Applications/Dilutions

Reactivity Notes

Packaging, Storage & Formulations

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Buffer

PBS (pH 7.3), 1.0% BSA and 50% Glycerol

Preservative

0.02% Sodium Azide

Purity

Immunogen affinity purified

Alternate Names for Proteasome 20S alpha 6 Antibody (OTI1A4)

EC 3.4.25.1

IOTA

Macropain iota chain

macropain subunit iota

MGC22756

MGC2333

MGC23846

Multicatalytic endopeptidase complex iota chain

P27K

p27KPROS-27

PROS2727 kDa prosomal protein

prosomal P27K protein

proteasome (prosome, macropain) subunit, alpha type, 6

Proteasome iota chain

proteasome subunit alpha type-6

proteasome subunit iota

Background

The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. A pseudogene has been identified on the Y chromosome. [provided by RefSeq].

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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