Along the way, as you travel across the lab, you will go from a relatively sanitary environment to one where it feels disgusting just stepping on the ground. Vats full of the specimens lie dormant or are deceased due to being failures (however, if they are less than human, expect them to break free to start munching on something), bits of Techno Wreckage lie about as you realize you are near the scientist or his ultimate creation, which will grant the following...

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This is common in the Metroid games, with the earliest example being Tourian in the first game. Tourian would appear again in Super Metroid and Metroid: Zero Mission, the latter of which is a remake of the first game; both of these later games make clear that the reason Tourian is abandoned is because the Metroids escaped and killed off the Space Pirates.

Metroid Fusion takes place pretty much entirely on one of these; B.S.L, a large space station full of various creatures from across the galaxy.

Metroid: Other M takes place in a station quite similar to the one from Fusion, used as laboratory for researching biological weapons. In fact, it appears to be the predecessor to the secret research carried on the B.S.L station.

Every game in the Metroid Prime subseries features at least one, usually belonging to the Space Pirates at some point. Corruption also featured a few that belonged to the Galactic Federation and the Elysians, while Metroid Prime: Hunters features two such labs that once belonged to the Alimbics.

At first in Portal 1, this is somewhat misleading, as G La DOS is still maintaining the test area (where the player spends the majority of his/her time in) where everything is as white and shiny as an iPod, everything that's supposed to move moves, and it seems to be all good, until the player finally reaches the last chamber where G La DOS tries to kill you and you make your way through the unmaintained area, you finally get a sense of how long this place has been abandoned. Even more so in Portal 2 where, G La DOS is dead, and the whole place is overrun by plants. But the area underground the more modern labs takes the cake. By the look of things, it was used in the 1950s and abandoned much later. Not to mention that the announcer in the stasis chambers says that you've been in stasis for nine nine nine nine nine nine nine.... days. Which means you've been asleep for quite a while.

Pokémon Red and Blue has the Pokemon Mansion, where the experiments to clone Mew to create Mewtwo took place (before it had Gone Horribly Right), and which is now filled with assorted Fire and Poison-types and the scientists' logs of their experiments.

Pokémon Colosseum has the Shadow Pokemon Lab, which has only recently been cleared out when you arrive.

The Shadow Pokemon Lab returns in Pokémon XD, though it's considerably less abandoned this time around, having been reclaimed by its former owners during the five years since Colosseum.

The BioSytems lab in Phantasy Star II. Birth Valley in IV is hinted to be the same location. In both games it's the birthplace of the cute Catgirl in your party.