adrenergic receptor

a site in a sympathetic effector cell that reacts to adrenergic stimulation. Two types of adrenergic receptors are recognized: alpha-adrenergic, which act in response to sympathomimetic stimuli, and beta-adrenergic, which block sympathomimetic activity. In general, stimulation of alpha receptors is excitatory of the function of the host organ or tissue, and stimulation of the beta receptors is inhibitory.

adrenergic receptor

Neurophysiology Any of a family of cell membrane receptors that receive neuronal impulses from postganglionic adrenergic fibers from the sympathetic nervous sytem, which are divided into α receptors, which results in an excitatory response of smooth muscle cells to catecholamines, and β receptors, which result in an inhibitory response to catecholamines; the GI tract is an exception, in that either α or β receptor stimulation results in relaxation

Adrenergic receptor

There are three families of adrenergic receptors, alpha1, alpha2 and beta, and each family contains three distinct subtypes. Each of the nine subtypes are coded by separate genes, and display specific drug specificities and regulatory properties.

Krambeck: "After intervention, the greatest improvement in symptom score was seen in the TURP group, followed by laser vaporization, then the drugs, 5 alpha reductase inhibitors and alpha adrenergic receptor blockers.

The paper concludes that in the Beta-Blocker Evaluation of Survival Trial (BEST) adrenergic polymorphism substudy, the norepinephrine lowering and clinical therapeutic responses to bucindolol were strongly influenced by the alpha-2C adrenergic receptor genotype.

In this study, Gencaro appeared to produce enhanced clinical outcomes in the 47% of patients who were homozygous for the amino acid position 389 arginine polymorphism of the beta-1 adrenergic receptor, a variant with higher functional activity and higher affinity for norepinephrine, which the Company believes is the most favorable genotype for a positive response to Gencaro.

The beta1-adrenergic receptor 389 Arginine/Glycine polymorphism is known to be influenced by racial differences that vary in European versus American populations, and other adrenergic receptor polymorphisms that could influence beta-blocker response also exhibit racial differences in allele frequencies.

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