Setting off the Body’s Sentinels

Researchers identified a new receptor on cells in the mouth, which they designated as CD36. This receptor, they found, interacted with oral bacteria. When CD36 was triggered, it in turn set off the body’s toll-like receptors. These receptors are in certain types of immune cells, often called sentinel cells because it’s their job to roam the body looking for signs of early infection and fighting back. When these cells are triggered, they release a compound that triggers inflammation in the body. This inflammation trigger has already been linked to the hardening of arteries.

A New Treatment Angle

With the discovery of CD36, researchers have identified a new potential angle for treating many of the problems related to gum disease. Gum disease’s negative impacts are partly due to the body’s own response. This triggers the hardening of arteries, and it can also be partly responsible for the loss of bone around your teeth that leads to tooth loss, as well as prostate symptoms associated with gum disease.

If researchers can find a way to suppress the CD36 receptor, by either preventing it from interacting with oral bacteria or stopping it from triggering sentinel cells, they can tone down the body’s immune response to oral bacteria. This would allow gum disease treatments more time to work before the body’s alarms lead to damage.

Oral Care Will Always Be Crucial

The body creates its responses because it knows that losing teeth or even developing heart disease is better than having a rampant infection in your mouth. If we are going to soften the body’s immune response, we will have to be extra vigilant about gum disease, with better oral hygiene, more regular dental visits, and better gum disease treatment.

The tradeoff might be worth it to prevent early death from heart disease.

If you are looking for a Sydney dentist to help you keep your mouth and body healthy, please call (02) 9686 7375 for an appointment at My Hills Dentist in Baulkham Hills.

My Hills Dentist is a full service local dental practice and a national leader in denture and dental implants technology. We offer comprehensive dental services to our neighbours in Baulkham Hills and Sydney, from basic preventive care to advanced restorative dentistry, sleep dentistry, and neuromuscular dentistry. My Hills Dentist was the first practice in the world to offer both FOY ® Dentures and BPS ® Dentures, and the addition of a new digital dental implants process gives our patients maximum flexibility in getting the best tooth replacement option available.

Dr. David Lee is a highly experienced cosmetic dentist with specialized training in dental implants, dentures, and accelerated orthodontics. Dr. Andrew J Ryu is a dedicated and compassionate dentist whose ongoing education is helping him move toward the forefront of the profession. Together they want to give you the best dental experience possible.