Growth cone at the tip of the axon of a primary hippocampal neuron at 1 day in vitro. Microtubules (Tuj1, Abberior STAR 580, red) are bundled in the central-domain suggesting a pausing state. The molecular motor myosin IIB (confocal, Alexa488, blue) is enriched at the transition-zone, along the F-actin arcs. In the peripheral domain actin forms bundles in the filopodia (Phalloidin, Abberior STAR 635, green). Imaged with Abberior Expert Line @ MPIbpc by Elisa D’Este.

Two subunits of the nuclear pore complex were immunolabelled using antibodies against gp210 and antibodies with multiple specificities (PAN4/5) and secondary antibodies coupled to Abberior STAR 580 and Abberior STAR 635P. Note that gp210 is localized in an eightfold symmetric structure at the rim of the nuclear pore complex.

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3D superresolution volume image of active zones at the Drosophila larval neuromuscular junction. Immunostaining for Bruchpilot and a second protein. Recorded using easy3D STED at 775nm. Samples by M. Lenz & M. Landgraf (University of Cambridge, UK).

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