Chromatin is a highly flexible architecture in which spatially and temporally coordinated changes between structurally condensed states (transcriptionally repressive), and structurally accessible states (transcriptionally active) regulate gene expression.

The novel forms of nucleotide moieties will be incorporated in oligomers with sequences relevant for biosystems. The compatibility of such artificial building blocks will be evaluated using advanced methods of quantum chemistry that provide also analytical tool for investigation of crucial noncovalent interactions.

Detailed molecular characterisation of the tumor or of patient predisposition in cases of hereditary forms of disease is a state of the art approach for high risk cancer patients’ diagnosis and treatment prognosis.