Brief report

Association Between 50 bp Insertion/Deletion Polymorphism in Promoter of the Superoxide Dismutase-1 and Temperament

Abstract

Mizaj, one of the basic concept of Iranian Traditional Medicine (ITM),
plays an important role in maintaining the healthy state of an individual as
well as diagnosis and treatment of diseases.
Despite its effectiveness, the mechanisms of mizaj dependence treatment in
practical ITM has not been steel well understood. This study was aimed to
evaluate any association between the mizaj and superoxide dismutase-1 (SOD1)
polymorphism. The study
was carried out on individuals healthy for blood donation. All participants were from Fars province,
southern Iran. To determine the Participants’ temperaments a self-reported
mizaj identification scale was used. Two hundred eighty males with
equilibrium or any of four simple mizajs (Warm, Cold, Moist, and Dry) were
included in the study. The SOD1 genotypes
were determined using a polymerase chain reaction (PCR)-based method. Multinomial logistic regression was used to calculate ORs
and 95% CI for the association of temperament with SOD1 polymorphism. No any association
between the Ins/Del polymorphism of SOD1 and
each of mizaj groups were found. The result of this study indicated that the temperament is not affected by the
Ins/Del polymorphism of SOD1. Further
research with larger samples and with other genes of antioxidant system is
recommended.