Thank you very much. (Applause continues.) Thank you very much. Thank you.

Well, thank you so much for the wonderful welcome. To President Cicerone, thank you very much for your leadership and for hosting us today. To John Holdren, thanks, John, for the outstanding work that you are doing.

I was just informed backstage that Ralph and John both are 1965 graduates of MIT. Same class. And so I'm not sure this is the perfectly prescribed scientific method, but there's sort of a control group.

(Laughter.) Who ages faster? The president's science adviser or -- or the president of the academy. And we'll check in in a couple of years. (Laughter.)

But it is -- it is wonderful to see them. To all of you, to my cabinet secretaries and team who are here, thank you. It is a great privilege to address the distinguished members of the National Academy of Sciences, as well as the leaders of the National Academy of Engineering and the Institute of Medicine, who have gathered here this morning.

And I'd like to begin today with a story of a previous visitor who also addressed this august body. In April of 1921, Albert Einstein visited the United States for the first time. And his international credibility was growing as scientists around the world began to understand and accept the vast implications of his theories of special and general relativity. And he attended this annual meeting and, after sitting through a series of long speeches by others, he reportedly said, "I have just got a new theory of eternity." (Laughter.) So I will do my best to heed this cautionary tale.

The very founding of this institution stands as a testament to the restless curiosity, the boundless hope so essential not just to the scientific enterprise, but to this experiment we call America. A few months after a devastating defeat at Fredericksburg, before Gettysburg would be won, before Richmond would fall, before the fate of the Union would be at all certain, President Abraham Lincoln signed into law an act creating the National Academy of Sciences. In the midst of Civil War, Lincoln refused to accept that our nation's sole purpose was mere survival.

He created this academy, founded the land-grant colleges and began the work of the transcontinental railroad, believing that we must add, and I quote, "the fuel of interest to the fire of genius in the discovery of new and useful things."

This is America's story. Even in the hardest times, against the toughest odds, we've never given in to pessimism. We've never surrendered our fates to chance. We have endured. We have worked hard. We've sought out new frontiers.

Today, of course, we face more complex challenges than we have ever faced before: a medical system that holds the promise of unlocking new cures and treatments attached to a health care system that holds the potential for bankruptcy to families and businesses; a system of energy that powers our economy but simultaneously endangers our planet; threats to our security that seek to exploit the very interconnectedness and openness so essential to our prosperity; and challenges in a global marketplace which links the derivative trader on Wall Street to the homeowner on Main Street, the office worker in America to the factory worker in China; a marketplace in which we all share in opportunity but also in crisis.

At such a difficult moment, there are those who say we cannot afford to invest in science, that support for research is somehow a luxury at moments defined by necessities. I fundamentally disagree. Science is more essential for our prosperity, our security, our health, our environment and our quality of life than it has ever been before. (Applause.) And if there was ever a day that reminded us of our shared stake in science and research, it's today.

We are closely monitoring the emerging cases of swine flu in the United States. And this is obviously a cause for concern and requires a heightened state of alert. But it's not a cause for alarm. The Department of Health and Human Services has declared a public health emergency as a precautionary tool to ensure that we have the resources we need at our disposal to respond quickly and effectively.

And I'm getting regular updates on the situation from the responsible agencies and the Department of Health and Human Services, as well as the Centers for Disease Control will be offering regular updates to the American people. And Secretary Napolitano will be offering regular updates to the American people as well, so that they know what steps are being taken and what steps they may need to take.

But one thing is clear: Our capacity to deal with a public-health challenge of this sort rests heavily on the work of our scientific and medical community. And this is one more example of why we can't allow our nation to fall behind.

Unfortunately, that's exactly what's happened. Federal funding in the physical sciences as a portion of our gross domestic product has fallen by nearly half over the past quarter-century. Time and again, we've allowed the research and experimentation tax credit, which helps businesses grow and innovate, to lapse. Our schools continue to trail other developed countries', and, in some cases, developing countries'. Our students are outperformed in math and science by their peers in Singapore, Japan, England, the Netherlands, Hong Kong and Korea, among others.

Another assessment shows American 15-year-olds rank 25th in math and 21st in science when compared to nations around the world. And we have watched as scientific integrity has been undermined and scientific research politicized in an effort to advance predetermined ideological agendas.

We know that our country is better than this. A half-century ago, this nation made a commitment to lead the world in scientific and technological innovation; to invest in education, in research, in engineering; to set a goal of reaching space and engaging every citizen in that historic mission. That was the high water mark of America's investment in research and development.

And since then, our investments have steadily declined as a share of our national income. As a result, other countries are now beginning to pull ahead in the pursuit of this generation's great discoveries.

Now, I believe it is not in our character, the American character, to follow. It's our character to lead. And it is time for us to lead once again. So I'm here today to set this goal: We will devote more than 3 percent of our GDP to research and development. We will not just meet but we will exceed the level achieved at the height of the space race, through policies that invest in basic and applied research, create new incentives for private innovation, promote breakthroughs in energy and medicine and improve education in math and science. (Extended applause.)

Now, this -- this -- this represents the largest commitment to scientific research and innovation in American history. Just think what this will allow us to accomplish: solar cells as cheap as paint; green buildings that produce all the energy they consume; learning software as effective as a personal tutor; prosthetics so advanced that you could play the piano again; an expansion of the frontiers of human knowledge about ourselves and the world around us. We can do this.

The pursuit of discovery half a century ago fueled our prosperity and our success as a nation in the half-century that followed. The commitment I am making today will fuel our success for another 50 years. That's how we will ensure that our children and their children will look back on this generation's work as that which defined the progress and delivered the prosperity of the 21st century.

Now, this work begins with a historic commitment to basic science and applied research, from the labs of renowned universities to the proving grounds of innovative companies. Through the American Recovery and Reinvestment Act, and with the support of Congress, my administration is already providing the largest single boost to investment and basic research in American history. That's already happened. This is important right now, as public and private colleges and universities across the country reckon with shrinking endowments and tightening budgets.

But this is also incredibly important for our future. As Vannevar Bush, who served as scientific adviser to President Franklin Roosevelt, famously said, "Basic scientific research is scientific capital." The fact is, an investigation into a particular physical, chemical or biological process might not pay off for a year or a decade or at all, and when it does, the rewards are often broadly shared, enjoyed by those who bore its costs, but also by those who did not.

And that's why the private sector generally under-invests in basic science, and why the public sector must invest in this kid of research, because while the risks may be large, so are the rewards for our economy and our society. No one can predict what new applications will be born of basic research, new treatments in our hospitals, new sources of efficient energy, new building materials, new kinds of crops, more resistant to heat and to drought.

It was basic research in the photoelectric field -- in the photoelectric effect that would one day lead to solar panels. It was basic research in physics that would eventually produce the CAT scan. The calculations of today's GPS satellites are based on the equations that Einstein put to paper more than a century ago.

In addition to the investments in the recovery act, the budget I proposed -- and versions have now passed both the House and the Senate -- builds on the historic investments in research contained in the recovery plan. So we doubled the budget of key agencies, including the National Science Foundation, a primary source of funding for academic research, and the National Institute of Standards and Technology, which supports a wide range of pursuits -- from improving health information technology to measuring carbon pollution; from testing smart-grid designs to developing advanced manufacturing processes.

And my budget doubles funding for the Department of Energy's Office of Science, which builds and operates accelerators, colliders, super computers, high-energy light sources, and facilities for making nano-materials, because we know that a nation's potential for scientific discovery is defined by the tools that it makes available to its researchers.

But the renewed commitment of our nation will not be driven by government investment alone.

It's a commitment that extends from the laboratory to the marketplace. And that's why my budget makes the research and experimentation tax credit permanent. This is a tax credit that returns $2 to the economy for every dollar we spend, by helping companies afford the often high cost of developing new ideas, new technologies and new products. Yet at times, we've allowed it to lapse, or only renewed it year to year. I've heard this time and again from entrepreneurs across this country. By making this credit permanent, we make it possible for businesses to plan the kinds of projects that create jobs and economic growth.

Second, in no area will innovation be more important than in the development of new technologies to produce, use and save energy, which is why my administration has made an unprecedented commitment to developing a 21st century clean energy economy, and why we put a scientist in charge of the Department of Energy. (Applause.) Our future on this planet depends on our willingness to address the challenge posed by carbon pollution. And our future as a nation depends upon our willingness to embrace this challenge as an opportunity to lead the world in pursuit of new discovery.

You know, when the Soviet Union launched Sputnik a little more than a half-century ago, Americans were stunned. The Russians had beaten us to space. And we had to make a choice: We could accept defeat, or we could accept the challenge. And as always, we chose to accept the challenge. President Eisenhower signed legislation to create NASA and to invest in science and math education from grade school to graduate school. And just a few years later, a month after his address to the 1961 annual meeting of the National Academy of Sciences, President Kennedy boldly declared before a joint session of Congress that the United States would send a man to the moon and return him safely to the earth. The scientific community rallied behind this goal and set about achieving it. And it would not only lead to those first steps on the moon; it would lead to giant leaps in our understanding here at home.

That Apollo program produced technologies that have improved kidney dialysis and water purification systems, sensors to test for hazardous gases, energy-saving building materials, fire-resistant fabrics used by firefighters and soldiers. More broadly, the enormous investment in that era in science and technology, in education and research funding produced a great outpouring of curiosity and creativity, the benefits of which have been incalculable. There are those of you in this audience who became scientists because of that commitment. We have to replicate that.

There will be no single Sputnik moment for this generation's challenges to break our dependence on fossil fuels. In many ways, this makes the challenge even tougher to solve, and makes it all the more important to keep our eyes fixed on the work ahead. But energy is our great project, this generation's great project.

And that's why I've set a goal, for our nation, that we will reduce our carbon pollution, by more than 80 percent, by 2050. And that is why -- (applause) -- and that is why I'm pursuing, in concert with Congress, the policies that will help meet us -- help us meet this goal.

My Recovery Plan provides the incentives to double our nation's capacity to generate renewable energy over the next few years -- extending the production tax credit, providing loan guarantees and offering grants to spur investment.

Take one example. Federally funded research and development has dropped the cost of solar panels, by tenfold, over the last three decades. Our renewed efforts will ensure that solar and other clean energy technologies will be competitive.

My budget includes $150 billion, over ten years, to invest in sources of renewable energy as well as energy efficiency. It supports efforts at NASA recommended as a priority, by the National Research Council, to develop new space-based capabilities, to help us better understand our changing climate.

And today, I'm also announcing that for the first time, we are funding an initiative recommended, by this organization, called the Advanced Research Projects Agency for Energy or ARPA-E.

And this -- (applause) -- this is -- this is based not surprisingly on DARPA, Defense Advanced Research Projects Agency, which was created during the Eisenhower administration, in response to Sputnik.

It has been charged, throughout its history, with conducting high-risk/high-reward research: the precursor to the Internet, known as ARPANET, stealth technology, the Global Positioning System. All owe a debt to the work of DARPA. So ARPA-E seeks to do the same kind of high-risk/high-reward research.

My administration will pursue as well comprehensive legislation to place a market-based cap on carbon emissions. We will make renewable energy the profitable kind of energy. We will put in place the resources, so that scientists can focus on this critical area.

And I am confident that we will find a wellspring of creativity just waiting to be tapped, by researchers in this room and entrepreneurs across our country. We can solve this problem. (Applause.)

Well, the nation that leads the world in 21st-century clean energy will be the nation that leads in the 21st-century global economy. I believe America can and must be that nation.

But in order to lead in the global economy, and to ensure that our businesses can grown and innovate and our families can thrive, we're also going to have to address the shortcomings of our health care system.

The Recovery Act will support the long-overdue step of computerizing America's medical records to reduce the duplication, waste and errors that cost billions of dollars and thousands of lives. But it's important to note, these records also hold the potential of offering patients the chance to be more active participants in the prevention and treatment of their diseases.

We must maintain patient control over these records and respect their privity -- privacy. At the same time, we have the opportunity to offer billions and billions of anonymous data points to medical researchers who may find in this information evidence that can help us better understand disease.

History also teaches us the greatest advances in medicine have come from scientific breakthroughs, whether the discovery of antibiotics or improved public health practices; vaccines for smallpox and polio and many other infectious diseases; antiretroviral drugs that can return AIDS patients to productive lives; pills that can control certain types of blood cancers; so many others. Because of recent progress -- not just in biology, genetics and medicine, but also in physics, chemistry, computer science and engineering -- we have the potential to make enormous progress against diseases in the coming decades. And that's why my administration is committed to increasing funding for the national institutes of health, including $6 billion to support cancer research, part of a sustained, multi-year plan to double cancer research in our country. (Applause.)

Next, we are restoring science to its rightful place. On March 9th, I signed an executive memorandum with a clear message: Under my administration, the days of science taking a back seat to ideology are over. (Boos, applause.) Our -- our progress as a nation and our values as a nation are rooted in free and open inquiry.

To undermine scientific integrity is to undermine our democracy. It is contrary to our way of life. (Applause.) That's why I've charged John Holdren and the White House Office of Science and Technology Policy with leading a new effort to ensure that federal policies are based on the best and most unbiased scientific information. I want to be sure that facts are driving scientific decisions, not the other way around. (Laughter.)

As part of this effort, we've already launched a website that allows individuals to not only make recommendations to achieve this goal, but to collaborate on those recommendations. It's a small step, but one that's creating a more transparent, participatory and democratic government.

We also need to engage the scientific community directly in the work of public policy, and that's why, today, I am announcing the appointment -- we are -- we are filling out the President's Council of Advisors on Science and Technology, known as PCAST. And I intend to work with them closely. Our co-chairs have already been introduced, Dr. Varmas and Dr. Lander, along with John. And this council represents leaders from many scientific disciplines who will bring a diversity of experiences and views. And I will charge PCAST with advising me about national strategies to nurture and sustain a culture of scientific innovation.

In addition to John -- sorry, the -- the -- I just noticed that I -- I jumped the gun here. Go ahead and move it up. (Laughter.) I had already -- I had already introduced all you guys. (Laughter.)

In biomedicine, just to give you an example of what PCAST can do, we can harness the historic convergence between life sciences and physical sciences that's under way today, undertaking public projects in the spirit of the Human Genome Project to create data and capabilities that fuel discoveries in tens of thousands of laboratories, and identifying and overcoming scientific and bureaucratic barriers to rapidly translating scientific breakthroughs into diagnostics and therapeutics that serve patients.

In environmental science, it will require strengthening our weather forecast, our earth observation from space, the management of our nation's land, water and forests and the stewardship of our coastal zones and ocean fisheries.

We also need to work with our friends around the world. Science, technology and innovation proceed more rapidly and more cost- effectively when insights, costs and risks are shared. And so many of the challenges that science and technology will help us meet are global in character. This is true of our dependence on oil, the consequences of climate change, the threat of epidemic disease and the spread of nuclear weapons. And that's why my administration is ramping up participation in and our commitment to international science and technology cooperation across the many areas where it is clearly in our interest to do so. In fact, this week my administration is gathering the leaders of the world's major economies to begin the work of addressing our common energy challenges together.

Fifth, since we know that the progress and prosperity of future generations will depend on what we do now to educate the next generation, today I'm announcing a renewed commitment to education in mathematics and science.

(Applause.) This is something I care deeply about. Through this commitment, American students will move from the middle to the top -- from the middle to the top of the pack in science and math over the next decade, for we know that the nation that out-educates us today will out-compete us tomorrow. And I don't intend to have us out- educated.

We can't start soon enough. We know that the quality of math and science teachers is the single most influential factor in determining whether a student will succeed or fail in these subjects. Yet in high school, more than 20 percent of students in math, and more than 60 percent of students in chemistry and physics are taught by teachers without expertise in these fields. And this problem's only going to get worse. There is a projected shortfall of more than 280,000 math and science teachers across the country by 2015.

And that's why I'm announcing today that states making strong commitments and progress in math and science education will be eligible to compete later this fall for additional funds under the secretary of Education's $5 billion Race to the Top program. And I'm challenging states to dramatically improve achievement in math and science by raising standards, modernizing science labs, upgrading curriculum and forging partnerships to improve the use of science and technology in our classrooms. (Applause)

I'm challenging states as well to enhance teacher preparation and training and to attract new and qualified math and science teachers to better engage students and reinvigorate those subjects in our schools. And in this endeavor, we will work to support inventive approaches. Let's create systems that retain and reward effective teachers, and let's create new pathways for experienced professionals to go into the classroom. There are right now chemists who could teach chemistry. (Laughter.) Physicists who could teach physics. Statisticians who could teach mathematics.

But we need to create a way to bring the expertise and enthusiasm of these folks -- folks like you -- into the classroom. There are states, for example, doing innovative work. I'm pleased to announce that Governor Ed Rendell of Pennsylvania will lead an effort with the National Governors Association to increase the number of states that are making science, technology, engineering and mathematics education a top priority.

Six states are currently participating in the initiative, including Pennsylvania, which has launched an effective program to ensure that the state has the skilled workforce in place to draw the jobs of the 21st century. And I want every state, all 50 states, to participate.

But as you know, our work does not end with a high school diploma. For decades, we led the world in educational attainment, and as a consequence, we led the world in economic growth. The GI Bill, for example, helped send a generation to college. But in this new economy, we've come to trail other nations in graduation rates, in educational achievement and in the production of scientists and engineers.

That's why my administration has set a goal that will greatly enhance our ability to compete for the high-wage, high-tech jobs of the future and to foster the next generation of scientists and engineers.

In the next decade, by 2020, America will once again have the highest proportion of college graduates in the world. That is a goal that we are going to set. And we've provided tax credits and grants to make a college education more affordable.

My budget also triples the number of National Science Foundation graduate research fellowships. (Applause.) This is a -- this program was created as part of the space race five decades ago, and in the decades since, it's remained largely the same size, even as the number of students who seek these fellowships has skyrocketed. We ought to be supporting these young people who are pursuing scientific careers, not putting obstacles in their path.

So this is how we will lead the world in new discoveries in this new century. But I think all of you understand it will take far more than the work of government. It will take all of us. It will take all of you. And so today I want to challenge you to use your love and knowledge of science to spark the same sense of wonder and excitement in the new generation.

America's young people will rise to the challenge if given the opportunity, if called upon to join a cause larger than themselves. We've got evidence. You know, the average age in NASA's mission control during the Apollo 17 mission was just 26. I know that young people today are just as ready to tackle the grand challenges of this century. So I want to persuade you to spend time in the classroom, talking and showing young people what it is that your work can mean, and what it means to you. I want to encourage you to participate in programs that allow students to get a degree in science fields and a teaching certificate at the same time. I want us all to think about new and creative ways to engage young people in science and engineering, whether it's science festivals, robotic competitions, fairs that encourage young people to create and build and invent -- to be makers of things, not just consumers of things.

I want you to know that I'm going to be working alongside you. I'm going to participate in a public awareness and outreach campaign to encourage students to consider careers in science and mathematics and engineering, because our future depends on it. And the Department of Energy and the National Science Foundation will be launching a joint initiative to inspire tens of thousands of American students to pursue these very same careers, particularly in clean energy.

It will support an educational campaign to capture the imagination of young people who can help us meet the energy challenge, and will create research opportunities for undergraduates and educational opportunities for women and minorities who too often have been under-represented in scientific and technological fields, but are no less capable of inventing the solutions that will help us grow our economy and save our planet. (Applause.)

And it will support fellowships and interdisciplinary graduate programs and partnerships between academic institutions and innovative companies, to prepare a generation of Americans to meet this generational challenge.

For we must always remember that somewhere in America, there's an entrepreneur seeking a loan, to start a business that could transform an industry. But she hasn't secured it yet.

There's a researcher with an idea, for an experiment that might offer a new cancer treatment. But he hasn't found the funding yet. There's a child with an inquisitive mind staring up at the night sky. And maybe she has the potential to change our world. But she doesn't know it yet.

As you know, scientific discovery takes far more than the occasional flash of brilliance, as important as that can be. Usually it takes time and hard work and patience. It takes training. It requires the support of a nation. But it holds a promise like no other area of human endeavor.

In 1968, a year defined by loss and conflict and tumult, Apollo 8 carried, into space, the first human beings ever to slip beyond Earth's gravity. The ship would circle the Moon 10 times before returning home. But on its fourth orbit, the capsule rotated. And for the first time, Earth became visible through the windows.

Bill Anders, one of the astronauts aboard Apollo 8, scrambled for a camera. And he took a photo that showed the Earth coming up over the Moon's horizon. It was the first ever taken from so distant a vantage point. And it soon became known as Earthrise.

Anders would say that the moment forever changed him, to see our world -- this pale blue sphere, without borders, without divisions -- at once so tranquil and beautiful and alone. We came all this way to explore the Moon, he said, and the most important thing is that we discovered the Earth.

Yes, scientific innovation offers us a chance to achieve prosperity. It has offered us benefits that have improved our health and our lives, improvements we take too easily for granted. But it gives us something more.

At root, science forces us to reckon with the truth as best as we can ascertain it. And some truths fill us with awe. Others force us to question long-held views. Science can't answer every question. Indeed it seems, at times, the more we plumb the mysteries of the physical world, the more humble we must be.

Science cannot supplant our ethics or our values, our principles or our faith. But science can inform those things and help put those values, these moral sentiments, that faith -- can put those things to work, to feed a child or to heal the sick, to be good stewards of this Earth.

We are reminded that with each new discovery and the new power it brings, comes new responsibility, that the fragility, the sheer specialness of life requires us to move past our differences and to address our common problems, to endure and continue humanity's strivings for a better world. As President Kennedy said when he addressed the National Academy of Sciences more than 45 years ago, the challenge, in short, may be our salvation.

Thank you all for all your past, present and future discoveries. (Applause.) May God bless you. God bless the United States of America. (Sustained applause.)