12-12-12 has arrived and the concert event of the year is going to rock the relief effort for Hurricane Sandy.

The "12-12-12: The Concert for Sandy Relief" kicks off Wednesday night with a live stream across the world broadcast from New York's Madison Square Garden.

The event will play host to some of the top musicians looking to lend their voice to raise money for those hardest hit by the country's latest hurricane.

It is sure to be one of the biggest concerts of the year with an estimated 2 billion people around the globe that will watch through a variety of platforms including television, movie screens, computers, and smart phones, according to The Los Angeles Times.

The event has been organized by many of the same people behind the Oct. 2001 Concert for New York City that was held after the infamous Sep. 11 terrorist attacks. Clear Channel Entertainment Enterprises president John Sykes is pulling no stops to make this year's relief event the biggest it can be. The producers are calling the concert the largest gathering of musicians ever put together at Madison Square Garden, according to the New Jersey Newsroom.

In November, NBC hosted the "Hurricane Sandy: Coming Together" telethon with performers including Bon Jovi, Bruce Springsteen and Billy Joel. The three top musical legends will be back to play at the 12-12-12 concert.