Incidence and Prevalence of Chronic Inflammatory Demyelinating Polyradiculoneuropathy: A Systematic Review and Meta-Analysis

Publication

Publication

Abstract
Background: Prevalence and incidence rates of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP)
are required to determine the impact of CIDP on society. We
aimed to estimate the prevalence and incidence of CIDP
worldwide and to determine the effect of diagnostic criteria
on prevalence and incidence.

Method: A systematic review
was conducted for all published incidence and prevalence
studies on CIDP until May 18, 2017. Methodological quality
was assessed using the Methodological Evaluation of Observational Research checklist. We performed a random effect
meta-analysis to estimate pooled prevalence and incidence
rates.

Results: Of the 907 studies, 11 were included in the
systematic review, 5 in the meta-analysis of incidence (818
cases; 220,513,514 person-years) and 9 in the meta-analysis
of prevalence (3,160 cases; 160,765,325 population). These
studies had a moderate quality. The pooled crude incidence
rate was 0.33 per 100,000 person-years (95% CI 0.21–0.53; I2 = 95.7%) and the pooled prevalence rate was 2.81 per
100,000 (95% CI 1.58–4.39; I
2 = 99.1%). Substantial heterogeneity in incidence and prevalence across studies seems to be
partly explained by using different diagnostic criteria.

Conclusion: These findings provide a starting point to estimate
the social burden of CIDP and demonstrate the need to
reach consensus on diagnostic criteria for CIDP.