The dysregulation of gene expression in the TNF-TNFR superfamily has been involved
in various human cancers including non-small cell lung cancer (NSCLC). Furthermore,
functional polymorphisms in TNF-α and TNFRSF1B genes ...

In vitro benzo[a]pyrene diol epoxide (BPDE)-induced DNA adducts in cultured peripheral
lymphocytes have been shown to be a phenotypic biomarker of individual's DNA repair
phenotype that is associated with cancer risk. In ...

Adiponectin secreted by adipose tissue has been implicated in prostate carcinogenesis.
Genetic variations in ADIPOQ are thought to influence the activity of adiponectin,
thus relating to cancer occurrence. In this hospital-based ...

p53 and p73 interact with human papillomavirus (HPV) E6 and E7 oncoproteins. The interplay
between p53 and p73 and HPV16 may lead to deregulation of cell cycle and apoptosis,
through which inflammation/immune responses control ...

Vascular endothelial growth factor (VEGF) is a major mediator of angiogenesis involving
in carcinogenesis, including lung cancer. We hypothesized that VEGF polymorphisms
may affect survival outcomes among locally advanced ...

ERCC2 is indispensable for nucleotide excision repair pathway, and its functional
polymorphisms may be associated with cancer risk. In a large case-control study of
1126 esophageal squamous cell carcinomas (ESCC) patients ...

Cell cycle deregulation is common in human cancer, and alterations of p27 and p21,
two critical cell cycle regulators, have been implicated in the development of many
human malignancies. Therefore, we hypothesize that p27 ...

Excision repair cross-complementation group 4 gene (ERCC4/XPF) plays an important
role in nucleotide excision repair and participates in removal of DNA interstrand
cross-links and DNA double-strand breaks. Single nucleotide ...

The repair of DNA double-strand breaks (DSBs) is the major mechanism to maintain genomic
stability in response to irradiation. We hypothesized that genetic polymorphisms in
DSB repair genes may affect clinical outcomes among ...