Traditional plant medicines are used for a range of cancer conditions. The chickpea is highly proteinaceous andconsumed as a staple in many parts of the world. An evaluation of chemoprotective and immunomodulatory activitiesof Cicer arietinum (CE) in cisplatin-induced immunosuppressed mice was here performed. Cisplatin was givenat 100mg/kg, intraperitoneally, and after induction of immunosuppression mice were treated with Cicer arietinum(0.5 mg/dose/animal/IP) for a period of 10-day. The influence of the extract on lymphoid organ weight, bone marrowcellularity, alpha esterase activity and on enzyme levels such as (SGOT,SGPT, Urea, Creatinine was assessed toidentify any chemoprotective influence. Administration of CE to cisplatin-treated mice alleviated the drastic reductionin bone marrow cellularity and α- esterase positive cells seen with cisplatin. Thus myelosuppression was reversed orinhibited. Cisplatin bids to DNA and causes damage resulting in chromosome breaks, micronucleus formation and celldeath. CE is comprised of numerous middle-chain aliphatic alcohols, aldehydes and ketones, in addition to compoundslike 7-hydroxy-1-methoxy-6-methylanthraquinone, cyclohexadecane (CAS) and 6-(amino methyl)-2-naphthol. Theselatter are thought to contribute to the characteristic aroma of C. arietimnum. In conclusion, administration of CEin cisplatin-treated mice, boosted bone marrow cellularity and increased α- esterase positive cells, thus reversingmyelosupproession.