The film explores what people will do when faced with humanity's last days. Can one man find his greatest love at the worst possible time? Dodge (Carell) and Penny (Knightley) meet in very unusual circumstances and the two connect causing their outlooks on like to brighten.

Seeking a Friend for the End of the World is directed by Lorene Scafaria, who also wrote the screenplay for Nick & Norah's Infinite Playlist.