Odighizuwa entered the league as a third round pick of the New York Giants in the 2015 NFL draft out of UCLA. In four seasons with the Bruins, Odighizuwa recorded 134 total tackles (24.5 tackles for loss), 12.5 sacks and seven passes defensed.

The defensive end doesn't have much to show for his career in the NFL. He appeared in four games as a rookie and recorded three total tackles. The following season, Odighizuwa was active for 14 games with the Giants. In his second season with the team, he recorded three total tackles and one pass defensed. Odighizuwa's time with the Giants came to an end late in August of 2017 when the defensive end was suspended the first four games of the season for violating the league's performance enhancing drugs policy. Odighizuwa worked out for the Cowboys in October, but did not sign with any NFL team last season.

Odighizuwa will have a chance to compete for a depth role with the Bills. Buffalo lacked a consistent pass rush in 2017. If Odighizuwa can stand out in this area, he has a chance to stick with Buffalo.