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Signal Transduction

Impedance Measurements

ECIS allows monitoring the signal transduction pathways activated by G protein coupled receptors (GPCR). This assay is based upon the widely accepted conjecture that GPCR activation, regardless of the second messenger, results in alterations of the cell's cytoskeletal elements. This culminates in morphological changes, and this is precisely the type of event detected in real-time and with great sensitivity by the ECIS System.