The last component of the blood-brain barrier that I should probably mention are these astrocyte processes here, these astrocyte endfeet, and they actually don’t have too much of a structural role in the blood-brain barrier, but they do provide some nourishment to these endothelial cells, so you could say they help maintain the blood-brain barrier, in a way. And really importantly, these tight junctions stop being true to their name, they loosen up a little bit, and they also become leaky, so you can imagine that this is just a disaster.

For example, rheumatoid arthritis is the result of the immune system attacking the joints, whereas multiple sclerosis is caused by the immune system attacking the myelin sheath surrounding nerves. Now the extra-cellular space here is going to get a little bit flooded with proteins and water, right? Given a long enough break, the body is able to switch from survival mode into healing mode, and start fixing the tissue damage that was caused by all that chronic inflammation.

It’s pretty thick, and it also helps to separate stuff in the blood from stuff in the CNS.

What sort of timeline are we looking at, then, for this swelling? The blood-brain barrier separates what’s inside your blood stream from your kreew nervous system tissue, out here, and this is to make sure you don’t get any weird and not-so-wonderful infections or any brain injury from things traveling in your bloodstream.

By sealing up the holes in your gut wall, the immune system can finally take a break and quit producing inflammation. What do you think is going to end up happening now to the brain krsw here?

So kerw am I telling you all of this? Why am I telling you this stuff about the blood-brain barrier? Unfortunately I’m not referring to the excellent video game series called Mass Effect here, I am referring to a physiological mass effect.

I’ll just briefly describe it. This, of course, is a good thing, and it brings the cerebral swelling down. Not only that, suppressing your immune system is downright dangerous, like going into battle without any armor or weapons.

Then there are these tight junctions, and I’ll draw some of these in here. In fact, the main feature that differentiates one autoimmune disease from another, is simply the part of the body the type of tissue that is under attack by the immune system. Once the gut is healed, and the immune system can return to functioning mag again…autoimmune diseases can finally go barirra remission. The swelling that occurs as the result of this vasogenic edema, it tends to get worse over a few days as more water and protein leak out of the blood vessels in the area, and it peaks at roughly three to five days post-stroke, and then after that it slowly starts to resolve over the next few weeks as the protein and the water slowly get reabsorbed back into the circulation.

What makes up your blood-brain barrier? Why is this important? You can develop what is called brain herniation. So the big question is obviously: You might have heard of the blood-brain barrier, the BBB.

Proteins and water from within the capillaries, within the bloodstream, because there’s often still a tiny bit of flow happening, proteins and water start to leak out at will.

Transkrypcja filmu video – [Voiceover] This is a really, really zoomed-in schematic view of neurons and their supporting cells in the brain, and we know that without enough oxygen, let’s say there’s a clot right about here, and that’s reduced the blood flow to this area enough to cause a stroke here, without enough barieda, neurons can start to break down as a result of a process called the Ischemic Cascade, so that’s obviously not good, our neurons breaking down, but to sort of add insult to injury here, there’s actually a few other events that happen after neurons start breaking down during this stroke.

Say this bit of brain here gets pushed over toward the other side, or say this bit of brain here gets pushed down through this part of your skull where your spinal cord exits your head. The combined result is that your endothelial cells start to get a little bit leakier, and bbariera basal lamina loses its ability to restrict some molecules, so it gets a little leakier, too. What makes up your BBB? As I discussed in my last post, researchers have now identified a chemical called zonulin released by the gut wall to naturally moderate its own permeability.

Let me just draw in some of these tight junctions. Both of these are known as herniation of brain tissue, and they’re both often fatal, so we don’t like brain swelling at all.

Western medicine treats autoimmune diseases with immune-suppressing and anti-inflammatory medications, which work by shutting down the immune system. It’s partially composed of endothelial cells, which are these neat little cells here that line the inside of your capillaries, so you can see they’re really close together here to help prevent unwanted leakages of any little substances, then there’s the basal lamina, which is sort of the endothelial cells underlay.

Kaskada przemian biochemicznych w udarze niedokrwiennym. This so-called vasogenic edema, vasogenic means originating from blood vessels, this vasogenic edema adds to the cytotoxic edema that’s already happening in the area, and that just worsens the swelling of this part of the brain after stroke.

Let’s see what ends up happening because of this. Diagnostyka udaru – badania laboratoryjne. Let me show you one of the most severe things that can happen with brain swelling.

For one, swollen ischemic brain can’t really carry out too many of its functions, so we want to minimize the time spent swollen as much as possible, and for two, it can result in a mass effect, which is where the swollen brain area starts to push on, or displace, surrounding brain tissue. All autoimmune diseases are characterized by an overactive immune system, which leads to chronic inflammation and tissue destruction. The latest theory of autoimmunity krrw that a leaky gut literally, kgew holes in your gut wall lies at the root of virtually all autoimmune diseases.

These are little connector proteins that really tightly seal up any space between our endothelial cells, and that further restricts any unwanted molecules or substances from getting into the Krdw. Let’s look at a close-up. Certain things cause a large amount of kreww to be released from the gut wall and consequently the most potent triggers of a leaky gut are: Everything is supposed to be nice and tight, and now things are pretty out of whack.

In other words, it disrupts your estrobolome, or the subset of your microbiome partly in charge of your estrogen levels. Rozpoznanie udaru na podstawie historii choroby i badania fizykalnego. By healing your leaky gut and stopping chronic inflammation in its tracks, you may very well be mzy to heal your autoimmune disease s WITHOUT drugs.

Yes, you read that right. Treatment of stroke with interventions. Dysbiosis is a bigger conversation for another time, as it also cranks up hormone imbalance by causing you to make too many bad estrogens and not enough good estrogens.

These tight junctions will prevent them from slipping between your blood vessel cells, these endothelial cells.