DRUG RESPONSE Report for: Masakazu KOHDA Lab #: A0001929One of the great promises of genetic testing is personalized medicine - allowingcaregivers to prescribe the medication that is optimal for you based on yourgenotype. Your genetics can cause some medications to be more or lesseffective, suggest optimal dosing levels, or in some cases lead to personalharm with the wrong medication. The Pathway Genomics Drug ResponseReport indicates which medications are optimal for you based on your genotype.Even if you are not currently taking any of these medications, this informationcould be critical in an emergency situation. Atypical Response Drug Name Drug Response Abacavir Hypersensitivity Caffeine Metabolism Carbamazepine Hypersensitivity Clopidogrel Metabolism Methotrexate Toxicity Statins Myopathy Statins Protection against myocardial infarction Tamoxifen Metabolism Warfarin Sensitivity

DRUG RESPONSE Report for: Masakazu KOHDA Lab #: A0001929Warfarin : SensitivityYour ResultsPatients with your genotype have increased sensitivity to warfarin and require lower initial doses. If you are currentlytaking, or considering taking, warfarin, please discuss your genetic results with your physician.About this medicationWarfarin (Coumadin) is a drug that is widely prescribed for the treatment or prevention of blood clots in conditions suchas arterial and venous thrombosis, pulmonary embolism and before surgical procedures such as heart valvereplacement. Warfarin is a difficult drug to manage because the correct dosage is highly variable in the population.Both genetic and nongenetic factors, such as food and other medications, can affect an individual’s sensitivity towarfarin. Determining the correct dosage is critical because too much warfarin can cause bleeding and hemorrhageand too little warfarin can lead to stroke or other complications. Pathway Genomics tests for common mutations in twodifferent genes that make individuals more sensitive to warfarin. Your genetic result *1/*1; AA Your genotype have increased sensitivity to warfarin and require lower initial doses. We evaluated the following markers Gene1 Marker1 Your Genotype2CYP2C9 rs1799853 C/CCYP2C9 rs1057910 A/AVKORC1 rs9923231 A/A

DRUG RESPONSE Report for: Masakazu KOHDA Lab #: A0001929Warfarin : SensitivityYour ResultsPatients with your genotype have increased sensitivity to warfarin and require lower initial doses. If you are currentlytaking, or considering taking, warfarin, please discuss your genetic results with your physician.About this medicationWarfarin (Coumadin) is a drug that is widely prescribed for the treatment or prevention of blood clots in conditions suchas arterial and venous thrombosis, pulmonary embolism and before surgical procedures such as heart valvereplacement. Warfarin is a difficult drug to manage because the correct dosage is highly variable in the population.Both genetic and nongenetic factors, such as food and other medications, can affect an individual’s sensitivity towarfarin. Determining the correct dosage is critical because too much warfarin can cause bleeding and hemorrhageand too little warfarin can lead to stroke or other complications. Pathway Genomics tests for common mutations in twodifferent genes that make individuals more sensitive to warfarin. Your genetic result *1/*1; AA Your genotype have increased sensitivity to warfarin and require lower initial doses. We evaluated the following markers Gene1 Marker1 Your Genotype2CYP2C9 rs1799853 C/CCYP2C9 rs1057910 Replication study で確立しているもの A/AVKORC1 rs9923231 A/A

HEALTH CONDITIONS Report for: Masakazu KOHDA Lab #: A0001929 Alzheimers disease, late onset Content Provided By: Pathway Genomics Genetics: Learn More Population Risk 13 /100 Will get this disease within their lifetime These results are based on your reported ethnicity of: Asian What We Tested and Your Results Gene/Locus1 SNP1 Your Genotype2 APOE Genotype APOE rs429358 T/T 3/3 APOE rs7412 C/C 3/3 See glossary at the back of the document for definitions of these terms What Should I Do? Your genetic profile is typical of the general population for Alzheimers disease, meaning your genetic predisposition for AD is average. In addition to maintaining a healthy diet and regular exercise plan, engaging in mentally-stimulating activities has been shown to lower one’s chance of AD ( PMID 16472203, PMID 19671904).

HEALTH CONDITIONS Report for: Masakazu KOHDA Lab #: A0001929 Alzheimers disease, late onset Content Provided By: Pathway Genomics Genetics: Learn More Population Risk 13 /100 Will get this disease within their lifetime These results are based on your reported ethnicity of: Asian What We Tested and Your Results Gene/Locus1 SNP1 Your Genotype2 APOE Genotype => APOE3/APOE3 APOE rs429358 T/T 3/3 APOE rs7412 C/C 3/3 See glossary at the back of the document for definitions of these terms What Should I Do? Your genetic profile is typical of the general population for Alzheimers disease, meaning your genetic predisposition for AD is average. In addition to maintaining a healthy diet and regular exercise plan, engaging in mentally-stimulating activities has been shown to lower one’s chance of AD ( PMID 16472203, PMID 19671904).