If you want to eek out all the velocity and accuracy from your load that you can, you might just start with your max safe load and experiment with seating depth and work down in charge until you find a recipie you like. If starting with your max load, changing seating depth could affect your pressures. When your blullet gets seated to the lands it will likely cause an increase in pressure. And when you seat the bullet deepr into the case you will decrease case capacity and also probably slightly increas pressure.