GREMLIN Results:
Residue pairs sorted by strength in covariance:Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

i

j

Raw Score

Scaled Score

81_S

88_H

1.1206

3.706

3_E

11_R

0.92441

3.057

23_Y

32_L

0.90753

3.002

44_S

47_A

0.87935

2.908

4_S

7_E

0.86992

2.877

3_E

8_I

0.76463

2.529

8_I

11_R

0.72451

2.396

79_E

88_H

0.62987

2.083

81_S

85_T

0.62418

2.064

38_R

66_H

0.61092

2.021

15_A

78_L

0.60105

1.988

47_A

89_I

0.56752

1.877

9_R

13_E

0.5488

1.815

27_K

36_E

0.53063

1.755

54_A

93_L

0.5299

1.753

33_P

36_E

0.52552

1.738

41_C

84_I

0.50096

1.657

17_E

20_R

0.49544

1.639

7_E

10_E

0.46802

1.548

50_L

90_A

0.46346

1.533

34_G

66_H

0.45865

1.517

14_A

80_G

0.45503

1.505

37_L

70_R

0.41374

1.368

6_A

10_E

0.40589

1.342

91_E

95_Y

0.40381

1.336

43_L

47_A

0.4025

1.331

61_S

64_G

0.39303

1.300

21_E

24_G

0.39241

1.298

79_E

87_E

0.39055

1.292

48_K

52_E

0.38788

1.283

14_A

18_R

0.37939

1.255

85_T

88_H

0.3673

1.215

47_A

50_L

0.34986

1.157

16_R

20_R

0.34881

1.154

16_R

28_C

0.34749

1.149

27_K

31_Q

0.3464

1.146

75_I

91_E

0.33741

1.116

44_S

85_T

0.3339

1.104

50_L

86_R

0.32665

1.080

60_L

93_L

0.32606

1.078

43_L

48_K

0.32505

1.075

52_E

56_E

0.32125

1.062

73_R

84_I

0.31871

1.054

45_S

49_K

0.31197

1.032

13_E

17_E

0.3106

1.027

68_I

93_L

0.30779

1.018

62_A

65_Y

0.30513

1.009

32_L

36_E

0.29732

0.983

10_E

13_E

0.29462

0.974

47_A

86_R

0.28848

0.954

61_S

94_S

0.28824

0.953

28_C

31_Q

0.28035

0.927

42_P

83_R

0.27912

0.923

17_E

21_E

0.27792

0.919

46_E

86_R

0.27776

0.919

50_L

53_Q

0.27755

0.918

10_E

14_A

0.27467

0.908

55_A

65_Y

0.27087

0.896

60_L

68_I

0.27007

0.893

14_A

17_E

0.26898

0.890

49_K

53_Q

0.26838

0.888

55_A

64_G

0.26693

0.883

19_Q

29_N

0.26442

0.875

18_R

82_E

0.2589

0.856

35_E

39_K

0.25817

0.854

64_G

96_R

0.24414

0.807

37_L

41_C

0.24338

0.805

50_L

89_I

0.24072

0.796

5_S

8_I

0.23837

0.788

44_S

83_R

0.23293

0.770

42_P

48_K

0.23106

0.764

60_L

64_G

0.22934

0.759

12_V

15_A

0.22145

0.732

50_L

54_A

0.21999

0.728

86_R

90_A

0.21999

0.728

44_S

86_R

0.21907

0.725

35_E

75_I

0.21071

0.697

64_G

67_R

0.20989

0.694

32_L

40_Y

0.20908

0.692

34_G

37_L

0.20641

0.683

62_A

93_L

0.20532

0.679

18_R

80_G

0.20446

0.676

71_V

95_Y

0.20401

0.675

22_R

77_D

0.2034

0.673

53_Q

56_E

0.20329

0.672

31_Q

65_Y

0.20258

0.670

73_R

76_A

0.2025

0.670

5_S

12_V

0.20246

0.670

23_Y

40_Y

0.20174

0.667

32_L

41_C

0.20165

0.667

6_A

14_A

0.20137

0.666

27_K

32_L

0.20119

0.665

13_E

55_A

0.2001

0.662

10_E

45_S

0.19959

0.660

38_R

94_S

0.19938

0.659

66_H

70_R

0.19905

0.658

39_K

87_E

0.19807

0.655

11_R

78_L

0.19505

0.645

81_S

87_E

0.19334

0.639

37_L

40_Y

0.19278

0.638

48_K

55_A

0.19217

0.636

49_K

52_E

0.19183

0.634

14_A

21_E

0.18858

0.624

54_A

58_L

0.18829

0.623

53_Q

57_K

0.18666

0.617

7_E

87_E

0.18272

0.604

14_A

83_R

0.1824

0.603

54_A

68_I

0.18126

0.599

13_E

20_R

0.17931

0.593

51_L

61_S

0.17844

0.590

4_S

44_S

0.1782

0.589

32_L

70_R

0.17662

0.584

65_Y

68_I

0.1763

0.583

81_S

84_I

0.1762

0.583

40_Y

84_I

0.17614

0.583

20_R

27_K

0.17587

0.582

76_A

88_H

0.17581

0.581

50_L

91_E

0.1734

0.573

29_N

32_L

0.17215

0.569

18_R

73_R

0.17189

0.569

35_E

42_P

0.17187

0.568

20_R

28_C

0.17126

0.566

45_S

48_K

0.16989

0.562

28_C

70_R

0.16982

0.562

16_R

23_Y

0.16956

0.561

58_L

95_Y

0.16952

0.561

23_Y

66_H

0.16933

0.560

48_K

84_I

0.16879

0.558

4_S

86_R

0.168

0.556

19_Q

73_R

0.16595

0.549

11_R

62_A

0.16527

0.547

11_R

15_A

0.16452

0.544

19_Q

65_Y

0.16427

0.543

16_R

30_A

0.1639

0.542

66_H

71_V

0.16248

0.537

41_C

47_A

0.16182

0.535

23_Y

95_Y

0.16173

0.535

73_R

91_E

0.16133

0.534

6_A

9_R

0.16116

0.533

52_E

65_Y

0.15984

0.529

Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.

HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits: Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)