Sisters High School offers six career academies. Students are required to take elective credits in a career academy of their choice. The goal is to make education more meaningful and thoughtful for students. A variety of programs suited to the unique interests of the student body account for part of Sisters High School's success. There are many unique, grant-funded programs offered throughout the Sisters Schools which help to make this an extra special place.

The science program incorporates laboratory work, chemistry, physics, biology, astronomy and wilderness ecology. The Sisters Science Club, a group made up of retired professors, doctors, and more have developed a co-curricular learning model that supports all sciences taught within the Sisters School Distrct. The Sisters Science Club also hosts the annual Science Fair every year in February.

Other co-curricular learning opportunities for students interested in math and sciences include: