About FETZIMA
See a complete overview of FETZIMA and how it can help treat depression.
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Take This Info With You
Download the FETZIMA Patient Brochure for a summary of the information on this site.
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FETZIMA SavingsProgram
The FETZIMA Savings Program may make your prescription more affordable.
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Take This Info With You
Download the FETZIMA Patient Brochure for a summary of the information on this site.
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How should I take FETZIMA?

Take FETZIMA exactly as your healthcare provider tells you to take it

Take FETZIMA at about the same time each day to help you remember

Your healthcare provider may need to change the dose of FETZIMA until it is the right dose for you

Talk to your doctor before you start or stop taking FETZIMA. Stopping FETZIMA suddenly can cause side effects

Take FETZIMA once daily with or without food

Swallow FETZIMA whole. Do not chew, crush, or cut FETZIMA

If you miss a dose of FETZIMA, take the missed dose as soon as you remember. If it is almost time for the next dose, skip the missed dose and take your next dose at the regular time. Do not take 2 doses of FETZIMA at the same time

If you received a sample pack from your healthcare provider, make sure you fill your prescription before finishing the sample pack to ensure that you continue taking FETZIMA as prescribed.

FETZIMA (levomilnacipran extended-release capsules) is a serotonin and norepinephrine
reuptake inhibitor (SNRI) indicated for the treatment of Major Depressive Disorder
(MDD) in adults.

FETZIMA is not approved for the management of fibromyalgia, and its efficacy and
safety have not been established for that use.

IMPORTANT RISK INFORMATION

What is the most important information I should know about depression, antidepressant
medicines, other serious mental illnesses, suicidal thoughts or actions and serotonin
syndrome?

FETZIMA and other antidepressant medicines may cause serious side effects.

What is the most important information I should know about depression, antidepressant
medicines, other serious mental illnesses, suicidal thoughts or actions and serotonin
syndrome?

FETZIMA and other antidepressant medicines may cause serious side effects.

WARNING: SUICIDAL THOUGHTS AND BEHAVIORS

Antidepressants increased the risk of suicidal thoughts and behavior
in children, teenagers, and young adults.
In patients of all ages who are started on antidepressant therapy, watch closely
for worsening depression and for suicidal thoughts and behaviors. Families and caregivers
of patients on antidepressants should talk with the patient's doctor if depression
becomes worse.
FETZIMA is not approved for use in patients under 18.

Call your healthcare provider right away if you have any of these
symptoms, especially if they are new, worse, or worry you:

Attempts to commit suicide; acting on dangerous impulses; acting aggressive; being
angry or violent; thoughts about suicide or dying; new or worsening depression or
anxiety; feeling very agitated or restless; panic attacks; trouble sleeping; new
or worsening irritability; an extreme increase in activity or talking (mania); or
other unusual changes in behavior or mood

Serotonin Syndrome: A rare, but potentially life-threatening
condition can happen when medicines such as FETZIMA are taken with certain other
medicines. Serotonin syndrome can cause serious changes in how your brain, muscles,
heart and blood vessels, and digestive system work. Symptoms of serotonin syndrome
may include: agitation; hallucinations; coma or other changes in mental status;
coordination problems or muscle twitching; fast heartbeat; high or low blood pressure;
sweating or fever; nausea; vomiting or diarrhea; or muscle stiffness or tightness

Who should not take FETZIMA?

DO NOT take FETZIMA if you:

Are allergic to levomilnacipran, milnacipran HCl, or any of the ingredients in FETZIMA

Have taken any drugs known as monoamine oxidase inhibitors (MAOIs) within the last
14 days, including the antibiotic linezolid or intravenous methylene blue

What should I tell my healthcare provider before taking FETZIMA?

Tell your healthcare provider if you:

Have high blood pressure or tend to have a fast heart rate

Have heart or kidney problems

Have or had bleeding problems. FETZIMA may increase your risk of bleeding or bruising

Have or had trouble urinating

Have or had mania, bipolar disorder (manic depression), seizures or convulsions

Have low salt (sodium) levels in your blood

Drink alcohol

Are pregnant, nursing, or are planning to become pregnant or to breastfeed

Tell your healthcare provider about all prescription, over-the-counter medicines,
vitamins and herbal supplements you are taking or plan to take, especially:

Triptans used to treat migraine headaches; medicines used to treat mood, anxiety,
psychotic or thought disorders, including tricyclics, lithium, SSRIs, SNRIs, buspirone,
or antipsychotics; tramadol, fentanyl; over-the-counter supplements such as tryptophan
or St. John's Wort, to avoid a potentially life-threatening condition

Aspirin, non-steroidal anti-inflammatory drug (NSAID) pain relievers, or blood thinners
(eg, warfarin, Coumadin®, or Jantoven®) because they may increase the risk of bleeding

Diuretics (water pills)

What should I avoid while taking FETZIMA?

Until you know how FETZIMA affects you, you should not drive, operate heavy machinery,
or engage in other dangerous activities

Avoid drinking alcohol while taking FETZIMA

What are the possible side effects of FETZIMA?

FETZIMA may cause serious side effects, including:

High blood pressure and/or increased heart rate

Abnormal bleeding: FETZIMA and other antidepressant medicines
may increase your risk of bleeding or bruising, especially if you take blood thinners
(eg, warfarin, Coumadin, or Jantoven), a non-steroidal anti-inflammatory drug (NSAID),
or aspirin

Visual problems: Eye pain; changes in vision; swelling
or redness in or around the eye. Only some people are at risk for these problems.
You may want to undergo an eye examination to see if you are at risk and receive
preventative treatment if you are

Low salt (sodium) levels in the blood: Symptoms may include
headache, difficulty concentrating, memory changes, confusion, weakness, and unsteadiness
on your feet. Severe or sudden cases may produce hallucinations (seeing or hearing
things that are not real), fainting, seizures, and coma. If not treated, severe
low sodium levels could cause death. Elderly people may be at greater risk

Tell your healthcare provider if you have any side effect that bothers you or that
does not go away. These are not all the possible side effects of FETZIMA. For more
information, ask your healthcare provider or pharmacist.

The product information provided in this site is intended only for residents of
the United States. The products discussed on this site may have different product
labeling outside of the United States.
The health information described on this site is provided for educational purposes
only and is not intended to substitute for discussions with a healthcare provider.