Areas of specialty

Our laboratory uses state-of-the-art multidimensional NMR spectroscopy along with computer aided molecular modeling to solve structural and dynamics problems in molecular pharmacology, rational drug designing, protein folding and solution phase biostructure. We are interested in utilizing structure of peptides, proteins, enzymes, receptors and acceptors as templates in drug designing. We are also interested in developing programs and routines for computer aided structure and conformation elucidation. Once an accurate model is determined, we use it as a template for design of appropriate constrained peptide ligands.

In summary, the integration of above mentioned knowledge such as structure-function and molecular recognition may play a key role for the successful design of pharmaceuticals in the future. Furthermore, these studies can guide the design of future experiments, particularly that employing recombinant DNA technology to create new protein structures useful in developing resistance to insects and diseases in plants and animals.