Sir: The trend of using serotonin selective reuptake inhibitors
(SSRIs) as first-line therapy for depression has brought
safe, effective, and well-tolerated therapy to countless patients.
However, many men and women taking these drugs (fluoxetine,
fluvoxamine, paroxetine, and sertraline) experience orgasmic
dysfunction. Attempts to help these unfortunate patients with
cyproheptadine, amantadine, yohimbine, and methylphenidate
have had mixed success.