Oscar winners Sam Rockwell, Octavia Spencer and Allison Janney have been set to star in The Heart, which will be the next film from writer-directors Nat Faxon and Jim Rash. The duo, who won the Adapted Screenplay Oscar with Alexander Payne for The Descendants, will also helm this one next and start shooting at year’s end after they wrap their current project, Fox Searchlight’s Downhill, now underway with Will Ferrell and Julia Louis-Dreyfus starring.

The Heart centers on Joe (Rockwell) and Lucy (Spencer) who, while desperate for cash, take the job of delivering a human heart from New York to Florida in 24 hours. When they realize their delivery is destined for a black-market buyer who illegally skipped the donor list, they attempt to reroute it to its rightful recipient, but they are soon hunted down by multiple insane criminals — including the greedy millionaire buyer, his scorned brother, and Lucy’s own drug-dealing ex-boss (Janney).

Manchester By the Sea producers Kevin Walsh and Ryan Stowell are producing via their The Walsh Company, and Sierra/Affinity is launching international sales next month at Berlin’s European Film Market. Sierra/Affinity also sold Faxon and Rash’s 2013 directing debut The Way Way Back, which also starred Rockwell, as well as 2016’s Manchester By the Sea, which won two Oscars and was nominated for Best Picture.

Rockwell is repped by Gersh and Untitled Entertainment, Spencer by WME and Jackoway Austen, and Janney by Gersh, Thruline Entertainment and Nelson Davis.

Faxon is repped by CAA, Artists First and Stone, Genow, and Rash by CAA, Atlas Artists and Stone, Genow.

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