This means that there is a conflict of ports which Spicework uses and another service.

2 Steps total

Step 1: Check to see if it really is a port issue error.

Launch Spiceworks, then on the taskbar right click the icon and choose "Preferences" and there in the text box "Spicewoks server HTTP port" you can try a different port like port "8080" and hit OK. This should launch Spiceworks again. If it loads up and opens a browser window then this is clearly a port error with another service. The usual culprit is IIS on the server.

Step 2: IIS is running on the server, how to fix the port error issues.

If IIS is running a Web Service the issue is that the Web Service is running on port 80, the same port that Spiceworks is trying to start up on.

A way to fix this can be either change the port that Spiceworks uses to startup if that is possible:

Or change the bindings on the webservice to a different port besides port 80 the link to do so is below: