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A compound derived from immune cells treats psoriasis in mice and holds promise for other autoimmune diseases. The compound suppresses an inflammatory pathway that is overactive in many autoimmune diseases, suggesting that it may be effective against multiple sclerosis, rheumatoid arthritis, lupus and other autoimmune diseases as well as psoriasis. [Press release from Washington University School of Medicine in St. Louis discussing online prepublication in Nature]
Press Release | Abstract

To study how estrogen receptor α (ERα) contributes to autoimmune diseases, researchers generated mice in which ERα was deleted specifically in T lymphocytes. They found that ERα deletion in T cells reduced their pathogenic potential in a mouse model of colitis and correlated with transcriptomic changes that affected T cell activation. [Sci Signal]
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Investigators found that IL-2 signaling through Janus kinase (JAK) 1 and JAK3 increased the abundance of a key subset of proteins to induce the accumulation of critical cytokines and effector molecules in T cells. [Sci Signal]
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The authors discuss the latest insights into the genetic and biochemical mechanisms linking immunity to the core circadian clock of the cell and hypothesize as to why the immune system is so tightly controlled by circadian oscillations. [Nat Rev Immunol]
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Obsidian Therapeutics, Inc. announced the presentation of preclinical data on its regulated cytokine programs. [Press release from Obsidian Therapeutics, Inc. (Business Wire, Inc.) discussing research presented at the 2018 Annual Meeting of the American Association for Cancer Research (AACR), Chicago]
Press Release