My itunes store wont open on my mac, it keeps saying "itunes could not connect to the itunes store. Make sure your network connection is active and try again". For days now I've tried everything I can think of to get to work. My Internet is working fine, I can open iTunes store on my iPads, iPhones etc, safari is working fine on my Mac, I've tried reinstalling iTunes, checked firewall settings, turned off router and Mac but still nothing. I'm running iTunes 11.0.1 mountain lion osx 10.8.2 and safari 6.0.2

I just tried logging in on another account like you suggested, still nothing. How do I do a repairing permissions?

As above, in short, open Disk Utilities in /Applications/Utilities, then click on your boot up volume (Probably named Macintosh HD) and hit the repair permissions button.

Edit: If this does not work you might try reinstalling iTunes or install the old iTunes 10.7, doubt reinstalling iTunes 11 will make a difference though.
At least you tries to log into another account and it did not solve the problem, this indicates the problem does NOT point to your normal User Account but is system wide.
Is there anything in the following folders.

/Library/LaunchDaemons
/Library/Little Snitch
/Library/StartupItems

To go to the Library folder (it's invisible by default) hit Command-Shift-G and paste: /Library :in it and hit enter.
You could also move the /Library/Preferences/SystemConfiguration to the desktop and restart, this resets all network settings.
**** move it don't delete it yet.

As above, in short, open Disk Utilities in /Applications/Utilities, then click on your boot up volume (Probably named Macintosh HD) and hit the repair permissions button.

Edit: If this does not work you might try reinstalling iTunes or install the old iTunes 10.7, doubt reinstalling iTunes 11 will make a difference though.
At least you tries to log into another account and it did not solve the problem, this indicates the problem does NOT point to your normal User Account but is system wide.
Is there anything in the following folders.

/Library/LaunchDaemons
/Library/Little Snitch
/Library/StartupItems

To go to the Library folder (it's invisible by default) hit Command-Shift-G and paste: /Library :in it and hit enter.
You could also move the /Library/Preferences/SystemConfiguration to the desktop and restart, this resets all network settings.
**** move it don't delete it yet.

Ok I've done the repair, still nothing.
In the LaunchDaemons folder there is
Com.adobe.fpsaud.plist
Com.microsoft.office.licensing.helper.plist
Com.trendmicro.itis.icore.agent.plist
in startupitems there is another folder icoreservice in that is
Icoreservice
Startupparameters.plist
And there is no little snitch folder

Ok I've done the repair, still nothing.
In the LaunchDaemons folder there is
Com.adobe.fpsaud.plist
Com.microsoft.office.licensing.helper.plist
Com.trendmicro.itis.icore.agent.plist
in startupitems there is another folder icoreservice in that is
Icoreservice
Startupparameters.plist
And there is no little snitch folder

I think I'd go with a re-insatll of itunes as above....Something is corrupt...The Itunes service should be running ( you can check in activity monitor >all processes. But I'd give itunes re-insatll a shot.

Ok I've done the repair, still nothing.
In the LaunchDaemons folder there is
Com.adobe.fpsaud.plist
Com.microsoft.office.licensing.helper.plist
Com.trendmicro.itis.icore.agent.plist
in startupitems there is another folder icoreservice in that is
Icoreservice
Startupparameters.plist
And there is no little snitch folder

You have little snitch running, if so turn it of for a moment or look in it's preferences, it might block iTunes!!!

Don't reinstall, uninstall that TrendMicro stuff first and restart, it should most likely resolve the problem.
And read the link I gave you.

Agreed, getting rid of that C*** should sort the OP out....Why do folks still think Macs need AV stuff? I've been using them for years and never ever had an issue...Worst thing? Dr OZ's spam email in the Cloud...

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EDIT:

OP, if you really MUST have an AV solution, you can use ClamXAV from the app store..it's free, but my advice is to stay away from any AV package.

Agreed, getting rid of that C*** should sort the OP out....Why do folks still think Macs need AV stuff? I've been using them for years and never ever had an issue...Worst thing? Dr OZ's spam email in the Cloud...

----------

EDIT:

OP, if you really MUST have an AV solution, you can use ClamXAV from the app store..it's free, but my advice is to stay away from any AV package.

Even better, I opened PC Malware/viruses on My mac in HexEdit, no damage ever.