• reduced formation of thrombi in Shwartzman-like reaction, an experimental model of hemorrhagic vasculitis induced by subcutaneous injection of LPS followed 24 h later by an injection of TNF-alpha in the same place

• platelet isolated from homozygous mice did not aggregate after ADP-induced activation in vitro

• reduced formation of thrombi in Shwartzman-like reaction, an experimental model of hemorrhagic vasculitis induced by subcutaneous injection of LPS followed 24 h later by an injection of TNF-alpha in the same place

• platelet isolated from homozygous mice did not aggregate after ADP-induced activation in vitro