Functional diffusion maps (fDMs) involve calculating
voxel-by-voxel changes in diffusivity in order to spatially localize and
quantify changes in tumor cellularity. Traditionally, fDMs are applied to
contrast-enhanced tumor regions exclusively. In the current study we have
expanded the application of fDMs to FLAIR abnormal regions. Results suggest
this technique provides additional insight into the growth and treatment
response of both enhancing and non-enhancing brain tumors, along with
reflecting the neurological status of the patient.