Product Details

Description

CD11a (LFA-1 α) together with CD18 constitute leukocyte function-associated antigen 1 (LFA-1), the αβ2 integrin. CD11a is implicated in activation of LFA-1 complex. LFA-1 is expressed on the plasma membrane of leukocytes in a low-affinity conformation. Cell stimulation by chemokines or other signals leads to induction the high-affinity conformation, which supports tight binding of LFA-1 to its ligands, the intercellular adhesion molecules ICAM-1, -2, -3. LFA-1 is thus involved in interaction of various immune cells and in their tissue-specific settlement, but participates also in control of cell differentiation and proliferation and of T-cell effector functions.

Alternative Names

LFA-1

Biological Information

Clonality

Monoclonal

Host

Rat

Reactivity

Mouse

Antigen

CD11a

Conjugate

Low Endotoxin

Isotype

IgG2a

Handling

Quantity

0.1 mg

Format

liquid

Storage

Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.

Buffer

The reagent is provided in azide-free phosphate buffered saline (PBS) solution, pH ≈7.4; 0.2 µm filter sterilized. Endotoxin level is less than 0.01 EU/µg of the protein, as determined by the LAL test.