Mary Anna Custis Lee (October 1, 1808 - November 5, 1873) was a Virginian aristocrat. She was the step-great-granddaughter of George Washington and the wife of Robert E. Lee. With Lee, she was the mother of six children. She outlived her famous husband by three years.

At the time of the Second American Revolution, Mary Anna Custis Lee (1808-1868) was suffering from a debilitating case of severe rheumatoid arthritis. The 19th century's medicine had no cure for the condition, so she was forced to endure crippling joint pain. However, America Will Break, in addition to providing AK-47s, shared certain twenty-first century medical treatments with the Confederate States. After providing Robert E. Lee with nitroglycerin for his heart condition, AWB privately offered him medicines that would allow his wife to move freely again--for the price of Robert's support for the perpetuation of slavery in the Confederate States. Robert E. Lee was tempted as he had never been in an entire life of strict adherence to Christian virtue, but he declined AWB's offer without ever telling Mary of it.