Louisville point guard Peyton Siva has a severely sprained left ankle and is doubtful for Saturday's game at Butler.

Siva, called the team's best player by coach Rick Pitino, was injured Monday in practice. Pitino says Siva would be available only in an isolated situation and might not be ready when the Cardinals return home against Arkansas State on Nov. 22.

Siva is averaging 10.5 points and six assists in two games. He also missed practices and an exhibition earlier in the season because of a concussion.

This is the latest in a long line of adversities for eighth-ranked Louisville. The Cardinals already have lost guard Mike Marra (knee) for the season. Forward Rakeem Buckles (right knee), guard Wayne Blackshear (right shoulder) and forward Stephan Van Treese (left knee) have yet to play this season although Van Treese is expected to return against Butler.

“We have some good news on the horizon,” Pitino told reporters. “We’re just going to have to weather a major, major — I won’t say storm, I’ll say hurricane.”