Influences on endometrial development during intrauterine insemination clinical experience of 2929 patients with unexplained infertility

Capsule:
There is increasing awareness of the importance of endometrial development in infertile patients. In a large unexplained infertility population, we describe the factors affecting adverse endometrial development during IUI cycles.

Result(s):
Of the 2,929 patients who met the inclusion criteria, 466 (15.9 %) achieved a clinical pregnancy. Pregnancy rates (PRs) increased significantly with increasing endometrial thickness on the day of hCG administration and with increasing serum E2 level, but were not significantly related to age, BMI, or follicle numbers according to multiple logistic regression modeling. Peak endometrial thickness declined with age and increasing E2 levels. The BMI was associated with thicker endometrium, but it was also associated with lower peak E2 levels.

Conclusion(s):
The impact of “endometrial factor” infertility may be underappreciated in IUI therapy. Targeted therapies to optimize the endometrium represent an important new area to improve in current fertility success rates.

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