Mouse Anti-Human IFN-gamma

Reconstitute the antibody in sterile water to a concentration of 1.0mh/mL.

Stability and Storage

The lyophilized antibody is stable for at least 2 years from date of receipt at -20°C. The reconstituted antibody is stable for at least two weeks at 2-8°C. Frozen aliquots are stable for at least 6 months when stored at -20°C.

Preparation

Produced in BALB/c mice using highly pure (>98%) recombinant human IFN-gamma as the immunizing antigen. This IgG1K antibody was purified from ascites fluid by antigen affinity chromatography.

Antigen

Recombinant human IFN-gamma

Application

ELISA, WB

Synonyms

IFNG; IFG; IFI;

Description

IFN-γ is an acid-labile interferon produced by CD4 and CD8 T lymphocytes as well as activated NK cells. IFN-γ receptors are present in most immune cells, which respond to IFN-γ signaling by increasing the surface expression of class I MHC proteins. This promotes the presentation of antigen to T-helper (CD4+) cells. IFN-γ signaling in antigen-presenting cells and antigen-recognizing B and T lymphocytes regulate the antigen-specific phases of the immune response. Additionally, IFN-γ stimulates a number of lymphoid cell functions including the anti-microbial and anti-tumor responses of macrophages, NK cells, and neutrophils. Human IFN-γ species-specific and is biologically active only in human and primate cells. Recombinant human IFN-γ is a 16.7 kDa protein containing 143 amino acid residues.