Major difference between mens and womens shoes?

Other than the obvious difference in sizing, how does the average women's shoe differ from a mens? Let's say I wear a 10.5 in a Nike 2K10 and the equivalent in a women's would be a 12. Is it gonna fit? Is it basically the same shoe only in chics colors? Or does Nike change it around to fit a women's foot? Same goes for the Breathe Frees that Nike made for years in women's after they stopped making it for men.

Other than the obvious difference in sizing, how does the average women's shoe differ from a mens? Let's say I wear a 10.5 in a Nike 2K10 and the equivalent in a women's would be a 12. Is it gonna fit? Is it basically the same shoe only in chics colors? Or does Nike change it around to fit a women's foot? Same goes for the Breathe Frees that Nike made for years in women's after they stopped making it for men.

In most cases, women-specific shoes will be narrower, particularly at the heel. However, it doesn't mean men cannot wear them (just remember the 1-2 size difference) if they fit, it just means the shape is designed to be proportionately more suitable to the average shape of a woman's foot.