Brain inflammation may initiate prion, Parkinson’s disease

Washington: Neuro-inflammation plays a crucial role in initiating prion disease, researchers of the Computational Biology group at the Luxembourg Centre for Systems Biomedicine have suggested.

Prion diseases represent a family of neurodegenerative disorders associated with the loss of brain cells and caused by proteins called prions (derived from ‘protein’ and ‘infection’).

The diseases are found in both humans and animals, such as Creutzfeld-Jakob disease and mad cow disease respectively. Although mostly harmless, prions can transform into infectious agents, which accumulate in the brain and destroy the nervous tissue.

But how exactly does the accumulation of prions cause destruction of the brain?

“Understanding the process by which prions destroy neurons is critical for finding a cure for prion disease,” said Isaac Crespo, first author of the publication.

He and his colleagues tackled this question with a computational approach: They ran their own computer programmes on experimental data generated by other research groups, and identified a set of 16 proteins that seems to control the onset of the disease. Interestingly, almost all of these proteins have known functions in neuro-inflammation.

“What we consider remarkable and constitutes our main finding, is the key role that neuro-inflammation plays in initiating prion disease. This finding is not only relevant for prion diseases, but also for other ‘protein misfolding diseases’ such as Parkinson’s and Alzheimer diseases” said Prof. Dr. Antonio del Sol, group leader of the Computational Biology group.