In 1952, Jacqueline met Congressman John F. Kennedy. Shortly after, he was elected to the United States Senate and the couple married the following year. They had four children, two of whom died in infancy. As First Lady, she aided her husband's administration with her presence in social events and her highly publicized restoration of the White House. On November 22, 1963, she was riding with her husband in a motorcade in Dallas, Texas, when he was assassinated. She and her children withdrew from public view after his funeral, and she remarried in 1968.

For the final two decades of her life, Jacqueline Kennedy Onassis had a career as a book editor. She is remembered for her contributions to the arts and preservation of historic architecture, her style, elegance, and grace. She was a fashion icon; her famous ensemble of pink Chanel suit and matching pillbox hat has become symbolic of her husband's assassination and one of the lasting images of the 1960s. She ranks as one of the most popular First Ladies and in 1999 was named as one of Gallup's List of Widely Admired People of the 20th Century in America.