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Nole should advance in 3 or 4 sets. Mayer should be proud of getting this far, but Novak is a heavy favorite in this match.

3 Roger Federer vs. 26 Mikhail Youzhny

Youzhny has a shot at pulling an upset here. First, how healthy is Roger’s back. Second, Youzhny did win a set off of Roger here last year and demonstrated some vulnerabilities. Third, Roger lost the 2012 Halle final on grass to a veteran player with a one-handed backhand. Having said all of that, unless Roger’s back is really hampering his play, an upset would be monumental. Roger should win in 3 or 4 sets.

4 Andy Murray vs. 7 David Ferrer

This should be an easy match to predict. The thing is David Ferrer beat Andy Murray one month ago in the quarterfinal round at Roland Garros. Ferrer won a Wimbledon tune-up event in the Netherlands. He also has beaten Andy Roddick and Juan Martin del Potro in succession. Ferrer is about as confident as he will ever be on grass. I think Murray wins, but this match could range from an easy win for Murray to a tight win for Murray to a tight win for Ferrer. I can’t see Ferrer blowing Murray out, but I think Ferrer may oddly have his best shot at reaching a major final in front of him. Expect a dogged effort from Ferrer, and all bets are off if Murray does not match that effort.

5 Jo-Wilfried Tsonga vs. 27 Philipp Kohlschreiber

It would have been dull to not predict at least one upset. Based on Tsonga’s 2011 grass court form, he should win this match and have a good shot at reaching the championship match (an upset now and then does make life exciting for tennis fans). Still, Kohlschreiber has a lot of tools and a great opportunity in front of him. He won Halle in 2011 and possesses one of the most well rounded games on the tour. Kohlschreiber, like Ferrer, has a great chance to make an impression at a major. For some odd reason, I think he rides his skill to a victory by playing loose tennis and seizing a fracture in the ceiling at Wimbledon.