SOMNOLENCE Clinical Trials and Studies

Treatments might be new drugs or new combinations of drugs, new surgical procedures or devices, or new ways to use existing treatments. The goal of clinical trials is to determine if a new test or treatment works and is safe. Clinical trials can also look at other aspects of care, such as improving the quality of life for people with chronic illnesses. People participate in clinical trials for a variety of reasons. Healthy volunteers say they participate to help others and to contribute to moving science forward. Participants with an illness or disease also participate to help others, but also to possibly receive the newest treatment and to have the additional care and attention from the clinical trial staff.

Rate of patients presenting a "sleep onset"; rate of patients without arterial hypotension nor a sleep episode within 120 minutes after oral solution administration ;; rate of patients that show a sleep episode but without arterial hypotension within 120 minutes after oral solution administration ;; rate of patients that show arterial hypotension within 120 minutes after oral solution administration but not a sleep episode;; Occurrence of arterial hypotension and a sleep episode within 120 minutes following a standardized meal; Changes in intestine-pancreatic neuropeptides including incretins (GLP-1 - GIP) following an oral glucose load, placebo fructose load, or standardized meal - correlation with the post-prandial BP drop.

Determination of the expression and enzymatic activity of salivary amylase.; Measurement of the mean sleep onset latency using the Multiple Sleep Latency Test (MSLT); Measurement of the Somnolence using Epworth and Karolinska scales

The aim of this study is to determine the effect of fluticasone/salmeterol on sleep quality in patients with COPD and to compare efficacy of Advair 250 compared to placebo on sleep.; daytime Somnolence

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