In view of those situations which follower of cam mechanism have complicated motion law in rise travel and return travel, basing on secondary development and applying synthetically of Pro/E, following the reverse turn principle of the tradition graphic method, the wholly parameterized design system was developed. Furthermore, virtual assembly and motion simulation had been realized. According to the parameter imported by the consumer, the system can generate automatically cam pitch curve and cam contour of 16 kinds of combination follower motion law. It can raise cam mechanism product design quality and efficiency.