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Online Cover In a Research Resource this week, Rigbolt et al. report a system-wide analysis of temporal changes in the proteome and phosphoproteome of human stem cells as they begin to undergo nondirected differentiation. The image is a representation of this systems-level study, with the "stopwatch" in the center representing the temporal nature of the data, the first bubble depicting human embryonic stem cells in culture, the second bubble depicting molecular structure of a chemical inducer of differentiation, the graph representing the coordinated changes in protein phosphorylation, and the phylogenetic tree representing a bioinformatic analysis of the changes in the proteome. The background image shows representative mass spectrometry data. [Image: Kristoffer Rigbolt, University of Southern Denmark]