More subversive than anything else on this list, it's also more hit or miss. Not to mention being more preachy. But there's no denying that when this show is on its game (as it often is) it satirizes like no other with a crudeness that, at one time, was shocking.
They even managed to stay controversial with their "will they won't they" depiction of Muhammad.

A show that requires attention, the Venture Bros is fast moving and very funny to those who catch all the jokes. You don't have to have grown up watching Johnny Quest (the show it most obviously satirizes), but it might help. More than being a satire of that show though, it's a satire of all children's cartoon programming.

The Best Seth McFarlane show, American Dad started out like a less-good, more-political family guy. But within one season it had changed into the most consistently entertaining show in Fox's Sunday night animation domination.

Best of all, none of the cut-aways that drive so many people away from family guy.

Probably the only show on this list that could just as easily be live action, King of the Hill never really found its place among Fox's other animation shows, yet managed to keep on chugging for 13 seasons (and 4 syndicated episodes).

This show never received the support it needed on Fox, where it ran for two seasons. I watched it on Comedy Central reruns and loved it. With better use of cutaways than Family Guy (and 5 years earlier) this show was ahead of its time.

only partway through season 1 and I'm already confident with this placement. It has been gradually improving from its already excellent pilot. This show could easily surpass other Loren Bouchard projects like Home Movies and Dr. Katz.

Too bad this show couldn't have gone longer, because the two seasons aired were excellent. What started as a superhero spoof in season one turned into a political spoof into one seemed at times like a surrealist absurd dream.

Probably one of the only shows on this list you haven't heard of, it's also the only one that says fuck unabashedly (and unbleeped). It's been cancelled after two seasons on HBO, but the two seasons totalled 20 episodes, and each episode has 2 stories, making for a total of 40, 15-minute narratives.

Remember when I said that it was hard for a cartoon based on a movie to be as good as the movie? I was talking about this show. While certain episodes are better than others (the harry potter and video game episodes spring to mind) this show was largely hit and miss.