Brodalumab achieved high levels of lesion clearance in the majority of patients with moderate-to-severe psoriasis, with results sustained through 120 weeks, according to findings from a long-term extension of the phase 3 AMAGINE trial presented at the 26th European Academy of Dermatology and Venereology (EADV) Congress.

More patients were eligible for rescue after week 52 in the 4- and 8-week treatment groups than in the patients receiving brodalumab every 2 weeks, suggesting the response was lower with less frequent dosing, Dr. Lebwohl noted.

According to sPGA measurement, 79.2% and 76.6% of subjects achieved sPGA of 0/1 while 53.3% and 56.2% of patients achieved sPGA of 0 at weeks 52 and 120, respectively.

Interpretation of efficacy data in the groups receiving 140 mg every 4 and 8 weeks was limited by the small patient numbers at week 120.

The researchers observed similar response rates in patients receiving 140 mg brodalumab every 2 weeks throughout the long-term extension. "The safety profile of brodalumab at 120 weeks was favourable, and consistent with that observed in 52-week studies," Dr. Lebwohl noted.

The overall exposure-adjusted AE rate was similar at 306.9 per 100 patient-years across all brodalumab dose groups. The most common AEs were nasopharyngitis, upper-respiratory-tract infection, arthralgia, and headache.

Overall, 247 serious AEs occurred, and 103 patients discontinued the study drug due to an AE.

Funding for this study was provided by Amgen and AstraZeneca; the analysis was performed by Leo Pharma, Ballerup, Denmark.