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The high prevalence of tuberculosis (TB) among Hispanic immigrant workers (HIW) and the traditional difficulty in reaching them with public health interventions suggests that finding innovative practices is essential in eliminating TB from the United States. Given the frequent concentration of HIW in certain companies, this study investigates the feasibility of using the workplace for TB interventions targeting HIW. Results from twelve focus groups conducted with HIW suggest that there is wide variation in knowledge about the disease, TB is stigmatized, and that there is significant interest in workplace-based public health interventions addressing TB as well as other health concerns.