Irinotecan-refractory disease in metastatic CRC patients: The BOND trials found greater RR and TTP with the combination of irinotecan, bevacizumab, and cetuximab in patients no longer responding to irinotecan-based chemotherapy.

Trials underway:

CALGB/SWOG Phase III study of patients with metastatic CRC treated with FOLFOX or FOLFIRI chemotherapy, then randomized to either cetuximab, bevacizumab, or both.