In 1431 Pope Eugene IV completely reorganized the studium with the bull In supremae, in which he granted masters and students alike the broadest possible privileges and decreed that the university should include the four schools of Law, Medicine, Philosophy and Theology. He introduced a new tax on wine in order to raise funds for the university; the money was used to buy a palace which later housed the Sant'Ivo alla Sapienza church.

However, the University's days of splendour came to an end during the sack of Rome in 1527, when the studium was closed and the professors dispersed; some were killed. Pope Paul III restored the university shortly after his ascension to the pontificate in 1534.

In the 1650s the university became known as Sapienza, meaning wisdom, a title it retains. In 1703, Pope Clement XI purchased some land with his private funds on the Janiculum, where he made a botanical garden, which soon became the most celebrated in Europe through the labours of the Trionfetti brothers.

University students were newly animated during the 19th-century Italian revival. In 1870, La Sapienza stopped being the papal university and became the university of the capital of Italy. In 1935 the new university campus, planned by Marcello Piacentini, was completed.

Sapienza University has many campuses in Rome but its main campus is the Città Universitaria (University city), which covers 439,000 m2 (4,730,000 sq ft) near the Roma Tiburtina Station. The university has some satellite campuses outside Rome, the main of which is in Latina.

In 2011 a project was launched to build a campus with residence halls near Pietralata station, in collaboration with the Lazio region.[8] In order to cope with the ever-increasing number of applicants, the Rector has also approved a new plan to expand the Città Universitaria, reallocate offices and enlarge faculties, as well as create new campuses for hosting local and foreign students.

The Alessandrina University Library[9] (Biblioteca Universitaria Alessandrina), built in 1667 by Pope Alexander VII, is the main library housing 1.5 million volumes; it has some important collections including collezione ciceroniana, Fondo Festa, etc.

Since the 2011 reform, Sapienza University of Rome has eleven faculties and 65 departments. Today Sapienza, with 140,000 students and 8,000 among academic and technical and administrative staff, is the largest university in Italy. The university has significant research programmes in the fields of engineering, natural sciences, biomedical sciences and humanities. It offers 10 Masters Programmes taught entirely in English.

In order to cope with the large demand for admission to the university courses, some faculties hold a series of entrance examinations. The entrance test often decides which candidates will have access to the undergraduate course. For some faculties, the entrance test is only a means through which the administration acknowledges the students' level of preparation. Students that do not pass the test can still enroll in their chosen degree courses but have to pass an additional exam during their first year.

On January 15, 2008 the Vatican cancelled a planned visit to La Sapienza University by Pope Benedict XVI who was to speak at the university ceremony launching the 2008 academic year[17] due to protests by some students and professors.[18] The title of speech would have been 'The Truth Makes Us Good and Goodness is Truth'.[19] Some students and professors protested in reaction to a 1990 speech that Pope Benedict XVI (then Cardinal Joseph Ratzinger) gave in which he, in their opinion, endorsed the actions of the church against Galileo in 1633.[17]

Italian Minister of Labor and Social Policies, President of the Italian Statistical Institute (Istat). Chief Statistician and Director of the Statistics Directorate of the Organisation for Economic Co-operation and Development (OECD) in Paris. Professor of Economic Statistics.

ex Professor at Cornell, University of Pennsylvania and Columbia, before becoming chair of the Columbia architectural department in 1966. He is presently Ware Professor Emeritus of Architecture at Columbia.