Open position for a research assistant at the University of Eastern Finland, Kuopio

Applications are invited for a 0.5-year full-time position within research group underthe supervision of Dr Leonid Yavich.

The research fellow will make electrophysiological experiments in mice, studying theeffects of drugs on electrical activity of brain. Prior experience in managing of smalllaboratory animals and stereotaxic surgeries is an advantageous. Research fellow willalso acquire skills in modern neurochemical research (including in vivo voltammetry).

The positions would suit applicants with MSc in biotechnology, pharmacy, pharmacology,neuroscience or a related discipline, and is available immediately.

Applicants should send a CV to Dr Leonid Yavich (leonid.yavich@uef.fi, tel: +358 405677997).----------------------------------------------------------------------------BCO-DP invites applications for 13 doctoral training positions for 2012-2015, funded by the Ministry of Education and Culture. The positions are available from the 1st of January, 2012, for postgraduate students wishing to conduct research completing in PhD degree in one of the Biocenter Oulu projects ongoing in 2012-2015. Deadline for the applications is Friday, November 11th 2011, at 15.00 PM local time.----------------------------------------------------------------------------Graduate student position in developmental biology is available at the Institute of Biotechnology, University of Helsinki. We are looking for an individual interested in developing highly innovative research projects on the TGF-beta type signaling in Drosophila development. The deadline for application is November 15, 2011.----------------------------------------------------------------------------A graduate student position is open in tumor genomics group (PI Lauri A. Aaltonen) at Biomedicum, University of Helsinki. We are looking for a genetics major who has finished his/hers M.Sc. studies, or is about to graduate soon. The applicant should be motivated, hardworking, have good interpersonal skills, and, preferably, have experience in laboratory work. Work would start as soon as possible, optimally in the beginning of December. We are accepting applications until 18.11.2011.----------------------------------------------------------------------------PhD student and post-doctoral positions are available in the Finnish Centre of Excellence in Cell-Extracellular Matrix Research at Biocenter Oulu. We are looking for enthusiastic and skilful post-doctoral candidates with a PhD degree in life sciences or an MD-PhD degree. Closing date for applications is December 2, 2011.----------------------------------------------------------------------------A PhD student position is available in the University of Helsinki, Cancer Gene Therapy Group (CGTG). CGTG is part of Molecular Cancer Biology Research Program, Haartman Institute and FIMM at the University of Helsinki and is located in Biomedicum Helsinki on the Meilahti campus. Our research focuses on developing oncolytic viruses for treatment of cancer. (1.11.2011)----------------------------------------------------------------------------A graduate student position is open in tumor genomics group (PI Lauri A. Aaltonen) atBiomedicum, University of Helsinki. We are looking for a genetics major who has finishedhis/hers M.Sc. studies, or is about to graduate soon. The applicant should be motivated,hardworking, have good interpersonal skills, and, preferably, have experience inlaboratory work. Work would start as soon as possible, optimally in the beginning ofDecember.

Our work focuses on cancer and tumor genetics, especially on the inherited predispositionto cancer. We have several dynamic projects on various cancer types utilizing state ofthe art methods in genetics research. We actively collaborate with Finnish and foreignresearchers and our group is part of the Finnish Centre of Excellence in Cancer GeneticsResearch.

The four-year position is funded by the Academy of Finland and it is available in thegroup of Professor Juhani Syväoja. The group studies the interplay between replicativeDNA polymerases and other replication proteins during the cell cycle in cultivated humancells. Multiple methods of molecular and cell biology are applied, the main techniquebeing chromatin immunoprecipitation (CHIP). The focus of the group’s research iscurrently expanding from specific replication initiation sites to a genome wide approachwith deep-sequencing methods included. The research facilities are excellent and thegroup has good and well-functioning international collaborative relationships. Applicantsshould have a strong background in bench-level molecular and cell biology. Experience ofchromatin immunoprecipitation methods will be regarded as a merit and readiness forco-supervision of PhD students is desirable.

A person to be appointed as a postdoctoral researcher shall hold a suitable doctoraldegree. In an ideal case the four-year position starts on January 1st, 2012. Later datesare possible, but would shorten the four-year period. The salary will be based on thesalary system of the Finnish universities. The salary is placed on level 5 (€2714.54).The total salary is comprised of a job requirement component and a personal performancecomponent. The personal performance component can comprise a maximum of 46.3% of the jobrequirement component.

The written application containing 1) a cover letter indicating the applicant’s previousachievements and motivation for this research, 2) the applicant’s CV with publications,and 3) the contact information of two professional referees, including the applicant’scurrent supervisor, should be sent to the registry office of the Joensuu or KuopioCampus: Postal addresses: University of Eastern Finland, Registry office, P.O. Box 1627,70211 Kuopio or University of Eastern Finland, Registry office, P.O. Box 111, 80101Joensuu. The application should also be e-mailed to Professor Juhani Syväoja,juhani.syvaoja@uef.fi

The deadline for applications is November 4th, 2011 at 15:00 (3 pm Finnish time).

Workplace: Department of Medical Biochemistry and BiophysicsForm of employment: Fixed term employment with possibility to extensionScope: Full-timeTime period: Duties wish to be taken as soon as possibleDescription of the work group/equivalent and its work/focus:

We invite applications for two post doctoral positions at our department.One position in Redoxregulation of autoimmune inflammation and one position inImmunespecific vaccination strategies using animal models.

Both positions will be placed at the Division of Medical Inflammation Research (seehttp://www.inflam.mbb.ki.se)Area of responsibilities/duties:

1) Post doctoral position in Redoxregulation of autoimmune inflammation.

A post doctoral position is now open for a highly motivated scientist with a strongbackground in experimental immunology and inflammation models. The project will focus onthe role of antigen-presenting cells regulating T cell immunity through oxidative burstwill be investigated. The Ncf1 gene has been positional cloned to be a major generegulating autoimmune arthritis and we have found the gene regulate both macrophage and Tcell reactivity. To sort out the underlying mechanisms operating in vivo we have made newmouse strains conditionally expressing the Ncf1 gene. The project will use these strainsto study the role of Ncf1 in different antigen-presenting cells.

A post doctoral position is now open for a highly motivated scientist with a strongbackground in cellular immunology and experimental animal work. The project will focus onimmune tolerance in experimental animal models. In the MIR lab we have developed newstrategies for therapeutic vaccination leading to protection against arthritis. It isbased on the discovery of critical posttranslationally modified peptides. The projectwill aim to understand the underlying specificity and mechanism of the vaccinationeffect. Various specifically designed mouse strains will be used.

NOTE: Please state in your application which position you are applying for.Qualifications: To qualify, the applicant must hold a doctor’s degree or a foreignqualification deemed equivalent to a doctorate in the field of medicine, biomedicine orbiology.

Postgraduates who have yet to graduate may apply if their public defense is scheduled totake place within three months after the application deadline, in which case verificationfrom the Dissertation Committee or equivalent body must be submitted with theapplication.

Experience of research work in experimental animal of rodents, and in cellular immunologyis needed. The candidate must also have knowledge in statistics. Fluency in English is arequirement.

The positions are available for 2 years and have the possibility to be prolonged.Dutieswish to be taken as soon as possible.

Karolinska Institutet is one of the world´s leading medical universities. Its mission isto contribute to the improvement of human health through research and education.Karolinska Institutet accounts for over 40 per cent of the medical academic researchconducted in Sweden and offers the country´s broadest range of education in medicine andhealth sciences. Since 1901 the Nobel Assembly at Karolinska Institutet has selected theNobel laureates in Physiology or Medicine.

The role of Nonclinical Safety Assessment, R&D, is to predict and ensure the safety ofnew chemical entities during various phases of drug development. In discovery phase it isimportant to exclude molecules with toxic properties when selecting drug candidates forfurther development. We support the drug research and development at all Orion’s coretherapy areas.

Your key responsibilities are to validate our new in vitro cytotoxicity assay and todevelop the result analyses of the assay. You will use an automated fluorescencemicroscope to measure multiple cytotoxicity parameters (high content analysis). You willvalidate the method by using reference compounds and develop data analyses with dataprocessing and visualization programs (e.g. Spotfire). In addition, you will find out andresolve toxicity mechanism by using in vitro techniques.

The position is temporary (maternity leave) starting from 1.1.2012 and lasting about oneyear.

You have preferably PhD level degree in biochemistry, cell biology, bioinformatics orrelated field, and you have several years’ expertise in research work. We expect that youhave deep experience in cell biology and in fluorescence microscopy and / or in analyzingof large biological datasets. In addition, experience on image analyses, methodvalidation and multiparameter-HTS/HCS (high throughput / high content screening)–techniques are regarded beneficial.

We expect our research scientist to be able to work both independently and inmultidisciplinary research teams. You have strong IT-skills and are familiar to work withdata handling software. Innovation and consistency are the features you need, when youdevelop and validate methods. Excellent oral and written communication skills in Englishare a must.

We offer challenging and interesting position in drug research as a member ofmulti-disciplinary team in modern facilities.

The prospective project is to understand the molecular mechanisms behind the mobility(long-range) and immobility (short-range) of signaling molecules are coordinated in thesame tissue. Since the research projects include the fields of Drosophila genetics,molecular biology, biochemistry, imaging analysis and high throughput approach such asgene expression profile analysis, they offer an interdisciplinary environment forresearch training.

The Neuroscience Center (NC) is an independent research and educational institute (see http://www.helsinki.fi/neurosci). Research and teaching in the NC focus on the following four areas: molecular and cellular neuroscience, developmental neuroscience, cognitive and systems neuroscience, and basic research of the nervous system diseases. The Center has currently 16 research groups and 150 staff members. The total budget in 2011 is 4.7 million euros. The NC has the following core facility units: mouse behavioural, zebrafish and neuronal cell culture units.

The Director's duties are to manage and supervise the NC’s activities and finances, and to participate in its scientific activities. The Director shall hold a doctoral degree. The appointee is expected to have excellent track record, knowledge of relevant scientific fields and experience in leading scientific research. The successful candidate should also have the ability and drive to work for the benefit of the scientific community. Start-up funding for the Director is negotiable. The Director's salary will be based on the salary system for teaching and research personnel of the Finnish universities.

The application written in English should contain the following: - a plan, how the applicant will develop the activities of the Center (max 5 pages), - a report of the previous achievements (max 5 pages), - a research plan of the Director’s research group (max 5 pages), - a publication list and - a curriculum vitae (2–3 pages)

The Scientific Advisory Board (http://www.helsinki.fi/neurosci/NC/SAB.html) issues a statement on the competence of the applicants and the Board submits a proposal for the appointment to the position of the Director. The Rector appoints the Director of the NC.

Written applications should be addressed to the Board of the NC and sent to the Registrar of the University of Helsinki, P.O. Box 33 (Yliopistonkatu 4), 00014 University of Helsinki, or emailed to hy-kirjaamo@helsinki.fi, to arrive no later than November 30, 2011.

The Glycoscience Graduate School (GGS) invites applications for PhD student positions for the period 1.1.2012-31.12.2013. The student positions can be granted for a period of few months to full two years based on the need and qualifications of the applying student.

The positions, provided by the Ministry of Education, are open for applicants with a Master´s level degree in medicine, biology, biologically orientated physics, biochemistry, chemistry, biotechnology or other suitable field to support full-time thesis project research. The salary of the doctoral students will be based on the salary system of Finnish universities. Applicants must work or start working in groups affiliated with GGS by 1.1.2012.

Application forms with the following appendices shall be sent to the GGS by email as a single PDF file. The signed application form must also be mailed to the coordinators by post.

Required information:

1. Free-form application letter

2. Application form

3. Research plan where the state of the thesis is described. When thesis is composed of independent papers, their state (published, submitted, manuscript in preparation, work in progress, experiments in planning) must be indicated.

4. CV

5. List of publications

6. All other documents relating to the postgraduate studies and study achievements

7. Based on point 3, please indicate the time needed for completion of the thesis/doctoral studies

An optimal application should

- Demonstrate that the applicant is motivated and has potential to develop into an independent researcher

- Demonstrate that the applicant will significantly benefit from the program

- Contain a scientifically significant and feasible thesis project

The postal address is:

Coordinator/Niina Tohmola or Ville Parviainen

Glycoscience Graduate School

Haartman Institute

Haartmaninkatu 3

00290 Helsinki

Finland

The email address is: GGS-coordinator@helsinki.fi

The deadline for the applications is November 11th, 2011. Late or insufficient applications will not be processed. Please note that applicants not affiliated to one of the groups of GGS will not be considered.