Before treatment:
Brisa was a full term delivered baby. Her mother had a premature rupture of the amniotic membrane and prolapse of the umbilical cord. She suffered from anoxia and suffocation, and received hyperbaric oxygenation. She had epileptic seizures and when she was born she took multiple antiepileptic drugs (including Oxcarbazepine, Urobanyl, Midazolam, Levetiracetam and Romparkin), and her attacks were controlled. Her motor functioning, swallowing ability and language ability were impaired. She was diagnosed with cerebral palsy. Due to the bad swallowing function, her nutritional state was bad, so she had PEG 5 years ago, and her nutritional state was better. Four years ago, her antiepileptic drugs were changed and she suffered from epileptic seizures again. This was the last time she had an attack. She started vomiting every morning in April 2015, the vomit contained sputum and secretion. The local doctors considered it as a special epileptic attack.

At present, she uses PEG, her cognitive abilities are impaired. She is able to understand other people’s words but she can’t speak except for the sound, “ah.” She is able to turn her body over and grasp things. She has spasms in the extremities, she is not able to sit up or walk. Her right hip joint was malformed. Her parents took her to our hospital for further treatment, and she was diagnosed with cerebral palsy.

Brisa was in good spirits. Her swallowing functioning was bad, she used PEG to eat. Her sleep was good. The color of the urine and the urine volume were both normal.

Admission PE:
Bp: 116/96mmHg. Hr: 105/min. Body temperature: 36.5 degrees, height: 143cms, weight: 37kgs. Brisa’s nutritional status was normal. There were no yellow stains or petechia on her skin or mucosa. She had congestion in her throat. The thorax was asymmetrical. The respiratory sounds in both lungs were rough, with rhonchus rales. There was sputum and secretion in her throat. The heart sounds were strong, the cardiac rate was normal, with no obvious murmur in the valves. The abdomen was soft, with no masses. There was PEG on the left upper quadrant, there was red granulation tissue around the PEG. There was deformity of the spinal column. There was no edema in the lower limbs.

Nervous System Examination:
Brisa Mac caddon was alert. Her intelligence was normal. She was able to understand what other people said, but she was not able to talk. The only sound she could make was “ah.” She was not able to do the orientation ability, memory, or calculation ability examinations. Her neck muscle power was weak, her head tilted to the left, but she was able to turn her head over to the right. Both pupils were equal in size and round, both pupils were sensitive to light stimulus. Their diameter was 3mms. Her eyeballs could move very well and there was no nystagmus. She was not able to cooperate with the tongue or oropharynx examinations. She was able to chew, but her swallowing ability was weak. She was not able to cooperate with the muscle examinations. The muscle tension of the upper limbs was lower than normal. The muscle tension of the lower limbs was higher than normal. Her right hip joint was malformed. The bilateral abdominal reflexes were normal. The bilateral radial periosteal reflex and biceps reflex were abnormal. The bilateral tendon reflex was normal sometimes. The bilateral side ankle reflex was abnormal. The bilateral ankle clonus was positive. The bilateral side sucking reflex and palm jaw reflex were negative. The Hoffmann sign and Babinski sign were negative. Brisa was not able to cooperate with the other examinations.

Treatment:
After admission, Brisa Mac caddon was diagnosed with cerebral palsy and secondary epilepsy. She received 4 neural stem cell injections and 4 mesenchymal stem cell injections to repair her nerves, initiate nerve development again, activate the stem cells in her body, nourish the neurons, regulate the immune system, and improve her blood circulation. She also had physical rehabilitation.

Post-treatment:
After 21 days of treatment, Brisa vomited less. Her cognitive ability improved. She spoke more words and she was able to cooperate with others better. The number of spasms decreased. Brisa was able to move her upper limbs better than before. She had intensive grasping movement exercises and afterwards she was able to grasp objects better than before. The muscle tension of the lower limbs was decreased. She was prescribed less antiepileptic medication and didn’t take urobanyl or Midazolam anymore. She took less doses of Romparkin.