Summary:
Lgt catalyses the transfer of an sn-1,2-diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a proliporotein [Sankaran94]. It is the first of 3 sequential reactions that result in the formation of mature triacylated lipoprotein.

Lgt is an essential inner membrane protein [Williams89, Pailler12]. Lgt contains 7 transmembrane segments; the N-terminus faces the periplasm and the C-terminus faces the cytoplasm [Pailler12]. Lgt is a peripheral membrane protein on the cytoplasmic side of the inner membrane [Sankaran94].

Sequence analysis, chemical inactivation, mutation, and complementation studies indicate that His-103 is essential for the activity of the enzyme; Tyr-235 and His-196 also have significant roles in its function [Qi95, Sankaran97].