Angiogenesis inhibition with bevacizumab, a monoclonal antibody against vascular endothelial growth factor A (VEGF-A), is an anticancer treatment associated with hypertension and renal glomerular toxi...

Purpose Bevacizumab improves progression-free survival but not overall survival in patients with metastatic breast cancer. E5103 tested the effect of bevacizumab in the adjuvant setting in patients wi...

Platinum-based chemotherapy plus bevacizumab is the new standard of care in stage IVB cervical cancer (CC) patients. In this new scenario, radical surgery could be offered in selected cases with an op...

Medical and Biotech [MESH] Definitions

Lethal Dose 50

The dose amount of poisonous or toxic substance or dose of ionizing radiation required to kill 50% of the tested population.

Dose Hypofractionation

A treatment schedule in which the total dose of radiation is divided into large doses.

Maximum Tolerated Dose

The highest dose of a biologically active agent given during a chronic study that will not reduce longevity from effects other than carcinogenicity. (from Lewis Dictionary of Toxicology, 1st ed)

Dose Fractionation

Administration of the total dose of radiation (RADIATION DOSAGE) in parts, at timed intervals.

Therapeutic Index, Drug

The ratio of the dose that produces toxicity to the dose that produces a clinically desired or effective response.