Author contributions: J.T. and R.Ru.: performed experiments; C.S., A.A., C.Y., and A.W.: analyzed data and interpreted the results; J.M.F. and C.B.: provided key biological material; P.M.: conceived the study, analyzed the data, interpreted the results, wrote the paper, and financially supported the study; R.Ro.: conceived the study, designed the study, performed experiments, analyzed the data, interpreted the results, wrote the paper, and financially supported the study; M.R.-M.: analyzed data and interpreted the results and financially supported the study. P.M. and R.Ro. share senior authorship.