WGS – Small Genomes

The UM DNA Sequencing Core can sequence entire genomes from bacterial, yeast, fungi or similar small genomes. Because of the relatively small size of these genomes, even a modest genome-scale sequencer can achieve reasonable coverage. Long read lengths are highly beneficial for assembling the data. If, however, you have numerous smaller genomes to sequence (e.g. 20 or more bacterial, yeast, etc) it may be worthwhile to consider multiplexing them all into one lane of the Illumina sequencer. The cost per genome will probably be much lower, as long as the Illumina data will suffice for your needs. Ask an experienced Bioinformaticist!