Ragetti was a member of the pirate crews, most notably aboard the Black Pearl, led by Hector Barbossa and Jack Sparrow. In his many journeys, Ragetti was rarely seen without his partner in crime and uncle, Pintel. Some time before the series he lost one of his eyes and now uses a wooden one.
Soon after joining Jack Sparrow's crew aboard the Black Pearl, Ragetti and many others joined Barbossa in a mutiny against Jack. It wasn't long after the crew found the Treasure of Cortés, that they became a cursed crew. They would spend the next ten years trying to lift the curse until it was lifted by Will Turner during a battle with the British Royal Navy. Along with the rest of the crew, Pintel and Ragetti were arrested and brought to the Port Royal prison. A year later, Ragetti and Pintel would escape the prison and join with Jack Sparrow's crew on the Black Pearl after escaping from the Pelegostos. Ragetti and Pintel would help Jack in finding the Dead Man's Chest in Isla Cruces. After Jack Sparrow was killed by the Kraken, Ragetti set out with a crew led by a resurrected Barbossa to rescue Jack from Davy Jones' Locker. It was through this journey that Ragetti would assist the Brethren Court in the fight against the East India Trading Company.