However, one of the potential side effects of Adrafinil (also known as Olmifon) is the build-up of harmful enzymes in your liver.

This Adrafinil liver toxicity (or hepatocixity) has been well documented and is something you need to keep in mind when considering whether or not this is a supplement to add to your routine.

But it is important to put the effects of Adrafinil on your liver into perspective and understand just how serious this problem is or how likely you are to develop issues.

Most people may not be aware that even well-known and reliable or ‘safe’ products also have a level of liver side effects associated with them.

As a comparison, Tylenol which contains Acetaminophen has a similar degree of liver toxicity with Adrafinil. In fact, the chief metabolite found in this commonly used over the counter medication is considered to be very poisonous.

Of course, there are a number of excellent benefits as well as ways in which the potential liver issues can be reduced. It will be up to you to determine whether those promised benefits outweighs the small chance of risk.

In order to do that, you should first understanding what exactly Adrafinil is, how it works, possible side effects, and exactly how it can affect the liver. It is also very important to know about liver toxicity in general.

In addition to being able to promote alertness and wakefulness, there are some noted Nootropic effects. This includes boosting one’s mood and mental energy. In many cases it also helps to enhance attention span, concentration, and even focus.

How Does Adrafinil Work?

A typical question asked is how does this supplement actually work. While the mode of action is complex and still not entirely understood, it is thought to effect both the Dopamine and Serotonin systems.

These are both very powerful neurotransmitters that contribute significantly to the way we think and feel at any given moment.

Dopamine helps to promote an enhanced mood and feelings of general well-being. Serotonin plays a pivotal role in controlling our sleep cycles and feelings of pleasure.

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Adrafinil also has a positive effect on histamines and the catecholamine norepinephrine. These hormones control your level of stimulation and help to direct your focus, attention and motivation to important stimuli.

This mechanism of action is very similar to that of Modafinil because Adrafinil actually gets converted into Modafinil when it reaches your liver. Some of the results may tend to improve productivity, mental performance and even reduce signs of depression.

Adrafinil Liver Effects:

One of the things that happens to this supplement in the liver is that it actual breaks down and turns into another compound called Modafinil. The process of breaking down and conversion does put some strain on the liver and raise levels of key enzymes.

Over time, if the levels of these enzymes continue to build it could cause long-term damage to this organ. These symptoms can become apparent after six months of daily use but different people will have different sensitivity levels.

Despite this, taking Adrafinil at recommended dosage levels is still considered to be safe for healthy individuals. Ideally, you should not be taking an Adrafinil dosage every day but rather cycling it to give your liver a chance to clear out those low levels of harmful enzymes.

Some people only take Adrafinil one or two days a week to ensure they do not run into any problems. If your liver does not have enough chance to rest, these chemicals can begin to accumulate and cause issues.

Of course, anyone who already has a history of liver issues should probably not take this without talking to a qualified medical professional.

Adrafinil Liver Toxicity In Perspective:

The problem with the liver in general is that it acts as a big processing center for the body. Anything that is not excreted unchanged by the body ends up going through the liver.

We put a lot of strain on our livers every time we drink alcohol, eat certain foods or take supplements that are metabolized in the liver. Unfortunately, some chemicals and supplements are harder on the liver than others.

Even aspirin has been noted to be harmful on the liver when used on a long-term basis. So, it would not be technically correct to think of Adrafinil (or even Modafinil) as being poisonous or toxic to liver. Instead, it is just a stage where the supplement is processed for more efficient use by the body.

Adrafinil Side Effects:

Unlike many other Nootropics, Adrafinil does carry a risk for some negative side effects. This is especially true when taken at high doses.

These can include increased blood pressure and heart related issues. Potential users who have existing heart and high blood pressure issues should avoid supplementation and consult with a qualified health professional. It should also not be combined with other stimulants like coffee and caffeine.

The recommended dosage for Adrafinil powder is between 150 and 300 mg per day. Of course, you should always start out with the lowest effective dosage in order to give your body time to adjust. You may even want to start lower than this range until you have become familiar with exactly how it works.

As mentioned previously, to avoid the risk of Adrafinil Liver Toxicity, you should take this supplement sparingly and not on a continuous basis.

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