System Message

Cdc45L Polyclonal Antibody

Cdc45L Antibody (A16594)

Western blot analysis of extracts from various cell types using Cdc45 Polyclonal Antibody.

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Product Details

Bioinformatics

Documents

A synthetic peptide corresponding to the carboxy terminus of human cdc45 protein

Conjugate

Unconjugated

Form

Liquid

Purification

purified

Storage buffer

0.01M HEPES, pH 7.5, with 100µg/ml BSA, 0.15M NaCl, 50% glycerol

Contains

no preservative

Storage Conditions

-20°C

Tested Applications

Dilution *

Western Blot (WB)

Assay Dependent

* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the
product for use in their own experiment using appropriate negative and positive controls.

Background/Target Information

The protein encoded by this gene was identified by its strong similarity with Saccharomyces cerevisiae Cdc45, an essential protein required to the initiation of DNA replication. Cdc45 is a member of the highly conserved multiprotein complex including Cdc6/Cdc18, the minichromosome maintenance proteins (MCMs) and DNA polymerase, which is important for early steps of DNA replication in eukaryotes. This protein has been shown to interact with MCM7 and DNA polymerase alpha. Studies of the similar gene in Xenopus suggested that this protein play a pivotal role in the loading of DNA polymerase alpha onto chromatin. Multiple polyadenlyation sites of this gene are reported.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.