Not really, this game is an exersize in precision, and a gamepad simply can't duplicate the precise movements needed. If anything, I think it would work wonderfully on a touchscreen, doubly so with multitouch. one hand on an edge pinching and opening to change amplitude, and the other along the bottom to tweak frequency.

The beauty of this really addictive game is in the simplicity of its mouse control. Though I use a gamepad for a lot of my FPS and driving games, plus games like Dishonored and Splinter Cell, I have to agree, this is one game where a gamepad just wouldn't feel right.