Skeletal hands appear in the Meiyerditch Dungeon, together with Mutated bloodveld and Zombie hands. Even though it's not aggressive by itself, at any time when you are in the dungeon, one might fall from the ceiling or crawl from underground and start attacking you. The Meiyerditch Dungeon can only be accessed during and after Legacy of Seergaze.

Skeletal hands may be killed instead of Crawling hands and Skeletons for Slayer tasks. Attacking skeletal hands will occasionally cause skeletal hands hanging from ceiling or buried in the ground to appear and attack you.