Abstract

Introduction

There are two well-defined pathways for colorectal carcinogenesis, the suppressor and the mutator pathways.

The suppressor pathway results from mutation in genes such as APC and MYH. These mutations are characteristic of hereditary polyposis colorectal cancer, known as familial adenomatous polyposis (FAP), attenuated familial adenomatous polyposis (AFAP) and MYH-associated polyposis (MAP).