If both drill and gerbers are plotted with absolute coordinates, they will
match.

In the Gerber Setup, Advanced Tab, there are three options. Center on film
is, in my opinion, a bad idea. The photoplot people, when they actually
make the film, will center it no matter what you do. the other options are
Reference to Absolute Origin and Reference to Relative Origin (i.e., the
relative origin currently set in the PCB file).

The same two choices (except for center) are also available in the NC drill
setup. As long as both references are set the same and the gerber and drill
files are generated at the same time, the coordinates should match.