Materials and methods: Human colon cancer cells (HT29 and SW620) were either incubated with Telmisartan (0,2-5,0ÂµM) or the full agonist Pioglitazon (25.0 ÂµM) as positive control for 24-72h (negative control: DMSO). Before incubation, the qualitative proof of PPARγ1 and PPARγ2 has been done by RT-PCR. The mRNA regulation of the target genes PPARγ2 and Cystatin A under the respective incubation has been measured by the means of qRT-PCR (housekeeping gene: bActin). Phenotypical changes were quantitatively determined by MTT Proliferations Assay. Apoptosis was determined by the Caspase-3/7 Assay. Statistic evaluation with PASW 18.0.