Our network includes four hospitals, six outpatient centers, two cancer centers and 700 physicians at more than 160 affiliated locations stretching from Alleghany Highlands and Rockbridge County to the Roanoke and New River Valleys.

Finding the right doctor is an important first step in managing your health and planning for your future. At LewisGale, you can choose from among the most experienced and highly trained physicians in their fields. We can help you make the best choice.

Natural Products to Avoid

Systemic lupus erythematosus (also known as SLE, or just lupus) is an autoimmune disease that primarily affects women of childbearing age. Its cause is unknown, but is believed to involve both genetic inheritance and factors in the environment. Whatever the cause, people with SLE develop antibodies against substances in their own bodies, including their DNA. These antibodies cause widespread damage and are believed to be primarily responsible for the many symptoms of this disease.

SLE may begin with such symptoms as fatigue, weight loss, fever, malaise, and loss of appetite. Other common early symptoms include muscle pain, joint pain, and facial rash. As SLE progresses, symptoms may develop in virtually every part of the body. Kidney damage is one of the most devastating effects of SLE, but many other serious problems may develop as well, including seizures, mental impairment, anemia, and inflammation of the heart, blood vessels, eyes, and digestive tract.

Conventional treatment for SLE revolves around a variety of anti-inflammatory drugs. In mild cases, taking nonsteroidal anti-inflammatory drugs (NSAIDs) may help; more severe forms of SLE require long-term use of corticosteroid anti-inflammatory drugs such as prednisone. The side effects of these medications can be quite serious themselves. So-called cytotoxic agents (azathioprine, cyclophosphamide, and chlorambucil) might also be helpful, but they have many side effects as well.

Close physician supervision is always required with lupus due to the risk of complications in so many organs.

Principal Proposed Natural Treatments

A meaningful body of evidence tells us that the hormone dehydroepiandrosterone (DHEA) may be helpful for the treatment of lupus, when used as a part of a comprehensive, physician-directed treatment approach.

DHEA is the most abundant steroid hormone found in the bloodstream. Your body uses DHEA as the starting material for making the sex hormones testosterone and estrogen. DHEA has been tried as a treatment for a variety of medical conditions, including
osteoporosis
, but it is showing its greatest promise in the treatment of SLE.

A 12-month,
double-blind, placebo-controlled trial
of 381 women with mild or moderate lupus evaluated the effects of DHEA at a dose of 200 mg daily.
1
Although many participants in both groups improved (the power of
placebo
is often amazing), DHEA was more effective than placebo, reducing many symptoms of the disease.

Similarly, in a double-blind, placebo-controlled study of 120 women with SLE, use of DHEA at a dose of 200 mg daily significantly decreased symptoms and reduced the frequency of disease flare-ups.
18

A smaller study found equivocal evidence that a lower dose of DHEA (30 mg daily for women over 45, and 20 mg daily for women 45) might also work.
20

A 2007 review of all published studies concluded that use of DHEA may meaningfully improve quality of life in the short term for people with lupus, but that it probably does not alter the long-term course of the disease.
21

For more information, including dosage and safety issues, see the full
DHEA
article.

Other Proposed Natural Treatments

Flaxseed
contains lignans and alpha-linolenic acid, substances with a wide variety of effects in the body. In particular, flaxseed may antagonize the activity of a substance called platelet-activating factor (PAF) that plays a role in SLE kidney disease (lupus nephritis). Preliminary evidence suggests that flaxseed might help prevent or treat lupus nephritis.
11,12

Fish oil
contains omega-3 fatty acids, which have some anti-inflammatory effects. Fish oil has been found useful in
rheumatoid arthritis
, a disease related to SLE. The results of two small
double-blind
studies suggest that fish oil might be useful for SLE as well.
13,19
However, current evidence suggests that fish oil is
not
effective for lupus nephritis.
14,15

Herbs and Supplements to Avoid

The herb
alfalfa
contains a substance called L-canavanine, which can worsen SLE or bring it out of remission.
16,17
People with SLE should avoid alfalfa entirely.

Various herbs and supplements may interact adversely with drugs used to treat lupus. For more information on this potential risk, see the individual drug article in the
Drug Interactions
section of this database.

Revision Information

This content is reviewed regularly and is updated when new and relevant evidence is made available. This information is neither intended nor implied to be a substitute for professional medical advice. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with questions regarding a medical condition.