This is an outstanding paper revealing that nitric oxide synthase-2 (NOS2)-driven production of NO is key to propagate growth of glioblastoma stem cells (GSCs) and arises as a promising target for an innovative GSC-directed approach of therapeutic intervention.

During the last couple of years, Jeremy Rich and colleagues have made a vast contribution to the current perception of GSCs as the germ centres of tumour growth and mediators...

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