Contraindication:

Contraindicated in Patients with significant respiratory depression; acute or severe bronchial asthma or hypercarbia in an unmonitored setting or in the absence of resuscitative equipment; known or suspected paralytic ileus; Patients with hypersensitivity to tapentadol or to any other ingredients of the product; who are receiving monoamine oxidase (MAO) inhibitors or who have taken them within the last 14 days due to potential additive effects on norepinephrine levels which may result in adverse cardiovascular events

Expert Advice:

Never crush or break a tapentadol pill to inhale the powder or mix it into a liquid to inject the drug into your vein.

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