The objective of this issue of Knowledge Gaps in Male Infertility is to highlight the several advances that have happened in the care of infertile men. Our goal in writing this is to identify what research is needed to move the field forward and, ultimately, imagine what issues need to be solved in order to bring male infertility care to the same level of diagnosis and treatment as female infertility. Our hope is that by identifying what the roadblocks are we can stimulate others to pursue the key areas in our field that are holding us back. This issue should stimulate others to look for funding opportunities and industry partnerships that can move us beyond these roadblocks.