**insulin is normally metabolized and then excreted in the proximal tubule. Patients with diabetes who get kidney disease stop filtering and metabolizing their insulin so their exogenous insulin requirement can decrease!

Protein Content of Normal Urine

<150 mg/24 hrs

20-30 mg albumin

glycoproteins and immunoproteins

proteins synthesized by distal tubules cells (ie: one that is lost in the urine but also used to make the matrix of casts)