Is it a Cache Problem?

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I am rendering with Redshift and not caching each frame of a growth simulation - with vdbs -. I have got around 1000 frames and about in every 250 frames it crashes and when I reopen the houdini file and render it, the rendering is extremely slow. Yet when I restart the machine its fast again. Why is this happening. I have attached the file. Do I necessarily need to cache the frames or is it something else?

I can disable and then enable the graphics card which helps and better than restarting the whole machine but still it would kill all the running houdini files.