Vayne

This build guide for Vayne is written by DontMashme, a Challenger ranked player on NA.
Vayne is a hypercarry with a relatively weak laning phase but huge lategame potentional. She has a very short attack range so positioning well and kiting is a must.

Required Reading:

Item Build

Starting Items

Doran's Blade

Warding Totem (Trinket)

Use a Doran's Blade if you are running lifesteal quints ( see runes option 2 ). This way you will be tankier on the early levels + you are still able to last hit under turrets because of the extra AD. The lifesteal from doran's blade and your runes will allow you to farm without having to worry too much about the enemy.

Mid Game

Berserker's Greaves

Doran's Blade

Doran's Blade

Greater Totem (Trinket)

On your first back you should buy start your life steal item by buying vamp sceptor and boots. If you are unable to buy vamp sceptor because of a tough lane then buy a second dorans.

The Bloodthirster

You have two choices for life steal items. BT should be picked against Squishies, for sieging and as a safe option / better for an unexperienced Vayne.

If you want to focus on poke and doging a lot then you should max Q ( which is in most of the cases )The thing with maxing W is that you actually need to get the 3rd proc to deal damage, while the Q is just easier to poke.

However if you want to you can try taking 2 points in Q then maxing W. If you do this the build i'd recommend ( and i'm currently using this one aswell ) is Botrk into 2x PD, pretty much going full attack speed.

Speaking of attack speed, is Runaan's a good idea? I am aware of how stupid this sounds, but it helps with farming and synergizes with Vayne's range (not Silver Bolts). Around mid game Vayne could be a sick split pusher. Also, does Tumble bonus damage proc on Runaan Hurricane arrows?

Runaan's is a bad item to be honest. The splash range is really low and it only gives attack speed, no other bonus and it's expensive.In most cases i splitpush as AD, not just as vayne, as long as you're ahead. I prefer the double PD for more attack and crit but if you want you can get statik shiv for splitpushing, its cheaper and better than Runaan's. I think tumble's damage procs 3x with runaan's but even then it's not worth it.I would only consider Runaan's if you are 2/3 inhibs down early and you are having troubles clearing the minions.

my skill arrangement..Q,W,E,Q,W,R,W,W,E,W,R,Q,Q,Q,E,R,E,E....it beacuse i think the W deal higher with 3rd att by help from blade of ruined king..combo is E on wall.Q and att...it will harass about 40% max health(base on your AD)

Quick note: postponing a level in Q increases the length of time before you are a late game beast. Vayne has 2 spikes: rank 5 Q and rank 5 W, then slow growth. Getting a level 2 E means instead of spiking at level 10, you will spike at level 11.

You have no last whisper, you won't shred through tanks and bruisers like you need to as an ad carry(bigger issue specially since armor is way easier to itemise for than mr and they are the ones who will jump onto you). Also, your core isn't that great, either go bork-pd-ie, bork-pd-ss/pd or bork-ie-lw-pd. A good build order, if you feel like you have godlike protection(lulu mid jannasupportalistar jungle or something) is Berserker's greaves/BotrK/ phantom dancer/statikk shiv/last whisper/infinity edge/zephyr(sell berserkers for the whole thing).If you don't, just go for one of the core and a build something like BotrK/IE/LW/PD/defensive item(frozen mallet, mercurial scimitar, banshee's veil or GA). You NEED either really good protection or a defensive item, in both cases, a last whisper.

What about Black Cleaver instead of Last Whisper? Anyway, Vayne is best known for her true damage which ignores any armor. The most dangerous thing for her isn't armor but rather attack speed debuffs from Frozen Heart and Randuin's Omen, which can be countered by building more attack speed.

actually, a very common misunderstand is that vayne can just not to buy last whisper since she has true damage, which ignores armor. It'd be great if she only dealt true damage, but still, most of her damage dealt is physical, the true damage does help against armor, but doesn't make you immune to it, not even close actually. Also, black cleaver is pretty much subpar on champions that don't apply a big amount of stacks with their abilities, champions like riven, zed, renekton, talon and urgot benefit from it, but ad carries in general don't, since, first, they will be focusing a high armor target(tank) and last whisper deals more damage than BC against a 100 armor target, and even if they focused a squishy one, they will get close to 100 armor passively and probably a zhonyas or ga anyway. In short, BC for ad casters, LW for ad carries(auto attackers).