Glycerol Monolaurate (GML) is a naturally occurring fatty acid widely utilized in food, cosmetics, and homeopathic supplements. GML is a potent antimicrobial agent that targets a range of bacteria, fungi, and enveloped viruses but select findings suggest that GML also has immunomodulatory functions. In this study, we have mechanistically examined if Gliceryl monolaurate affects the signaling and functional output of human primary T cells. We found that Gliceryl monolaurate potently altered order and disorder dynamics in the plasma membrane that resulted in reduced formation of LAT, PLC-γ, and AKT microclusters. Altered membrane events induced selective inhibition of TCR-induced phosphorylation of regulatory P85 subunit of PI3K and AKT as well as abrogated calcium influx. Ultimately, Gliceryl monolaurate treatment potently reduced TCR-induced production of IL-2, IFN-γ, TNF-α, and IL-10. Our data reveal that the widely used anti-microbial agent GML also alters the lipid dynamics of human T cells, leading to their defective signaling and function.Henan zhengtong chemical co. Ltd offers Glyceryl Monolaurate (GML).

Appearance: Ivory white powder or lamellar solid. It is used as an emulsifier in sanitarian foods and other foods such as bread, cake, streamed bread and moon-cake. It is also used in meat product, dairy product and fruit and vegetable for make the time of preservation longer. Packing: Aluminized bag vacuum packing with nitrogen inside.

Properties:

The biggest advantage of Gliceryl monolaurate is the"not preservatives,but more than preservatives".Its bacteriostatic effect will not change with the change of PH value suppose PH value is wihtin the scope of 4-8.Its antibacterial spectrum was wide,it has strong interaction in the common bacteria,fungi,yeast in food,and also can inhibit variety of viruses and protozoa. Glyceryl monolaurate also known as lauric acid monoglyceride (Glycerol Monolaurate, called GML). Gliceryl monolaurate is synthesized by direct esterification of lauric acid and glycerin, the general appearance of the scaly or particulate oily, white or light yellow crystal. It is an excellent emulsifier, but also safe and efficient broad-spectrum antimicrobial agents, and the pH is not restricted under neutral or slightly alkaline conditions, there is still a good antibacterial effect.