Animal Models of Parkinson’s Disease

Creative Animodel provides the one of the most comprehensive service platform for animal model based Parkinson’s disease studies, from model selection, model creation to therapeutics assessment, so that to accelerate the advancement for new drug and therapeutics from pre-clinical into clinical studies.

We have experienced experts to work with you to choose and develop the most appropriate model for your studies, and help you set up a detailed study plan. Furthermore, we also assist you with project executing, data validation and final report.

Classical models for Parkinson’s disease are toxin-based animal models, the unilateral 6-OHDA-lesioned rodent and the MPTP-treated primate. More extended animal models including transgenic animals like those related to PINK1, Parkin, alpha-synuclein and LRRK2 alterations. And other vertebrate models such as zebrafish and invertebrate models like fruit fly and round worms are ideal for studying the molecular and cellular mechanisms of Parkinson’s disease. Creative Animodel fully understands advantages and limitations between each kind of animal models for investigating Parkinson’s disease. It is essential for your research to find the best matching animal model at the beginning. We will work side-by-side with you to decide the most appropriate model for your specific experimental hypotheses.

Parkinson’s disease is one of the most common neurodegenerative disease, affecting 1% of the aging population. Parkinson’s disease is a neurodegenerative motor disorder, characterized by loss or paucity of movement, postural instability, resting tremor, rigidity, and altered gait. This disease is mostly caused by the continuous loss of dopaminergic (DAergic) neurons of the substantia nigra pars compacta (SNc)，a profound loss of dopamine (DA) in the striatum, and the presence of intracytoplasmic inclusions called Lewy bodies (LB), which are composed mainly of α-synuclein and ubiquitin. And although there have been several significant findings about the PD disease process, much of this process still remains unknown. A range of animal models has been used to study the pathogenic mechanisms and evaluate potential therapies of Parkinson’s disease. Two main types of models based on administration of toxins, either locally (6-hydroxydopamine, 6-OHDA; 1-methyl-4-phenyl-1,2,3,6-tetra- hydropyridine, MPTP) or systemically (reserpine, MPTP, rote- none, proteosomal inhibitors), has been used to test potential therapeutic strategies according to their behavioral phenotypes. Also new animal models like transgenic mouse model can help for identification patients with specific mutations.

Creative Animodel is dedicated to create the most suitable animal models of Parkinson’s disease to advance the development for potential therapeutics into clinical studies. We will be with you on every step for obtaining meaningful and suggesting data from animal model studies for Parkinson’s disease.