One week into the Giro d'Italia and the real hostilities open on this long, tough day through the hinterlands of the Marche region. The first half from Cesena crosses the Rubicon, traverses the Republic of San Marino, then challenges the steep climbs of Monte Catria, Monte delle Cesane and the final ascent into Saltare. Strong riders will reign here; don't be surprised if the Giro favourites Basso, Cunego, DiLuca and Simoni are fighting it out for the win.