Unless you're running Leopard, that is. Currently, the game's system requirements only list Tiger, and while MacWorld doesn't know whether Leopard is supported or not, they're not alone-- I called Laurie at "Pirates Online Customer Support" (boy, Disney sure poured a lot of money into this one), and while she was very helpful, she didn't know whether Leopard was supported or not. I threw a note into their system to try and check, and if I hear back, I'll update the post.

Of course, you could just try downloading and running it yourself in Leopard, but then again this is only one day after Halloween, and running unsupported Disney software on your Mac is pretty scary -- might be a little much along with everything else.