Answer to Question #73004 in Cell Biology for Jordan

Which of the following statements best describes the arrangement of R groups around the missing phenylalanine amino acid in the mutant CFTR protein?
The hydrophilic R group of either methionine (m) or tryptophan (w) are now pointing out into the cell, where they can interact with the water in the cellular fluid.
The hydrophobic R group of either methionine (m) or tryptophan (w) are now shifted away from the IIG sequence because they no longer have the hydrophobic phenylalanine to interact with.
There is no change in the location of the R groups around the missing phenylalanine so the tertiary structure remains the same.
The R group of either methionine (m) or tryptophan (w) are now shifted away from the IIG sequence because they no longer have an opposite charge on phenylalanine to be attracted to.

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Expert's answer

2018-01-31T04:48:07-0500

The correct answer isThe hydrophobic R group of either methionine (m) or tryptophan (w) are now shifted away from the IIG sequence because they no longer have the hydrophobic phenylalanine to interact with.

Methionine and tryptophan are hydrophobic, and they form hydrophobic interactions with phenylalanine in the normal protein.