Opening Odds & Line Movement
Open: -7.5 -105 at Pinnacle
This NFL odds opened at -7.5 for the Patriots at home and has bounced back and forth between -7 and -7.5, where it sits as of Thursday. The Bills are coming off a huge win on the road against the New York Jets, Ryan's former team, and it was very emotional for the coach. The Patriots didn't play their best game after destroying teams for most of the season, but they pulled out a win on the road against the New York Giants. That is what championship teams do: they win when they probably don't deserve to. Combine that with the history between Ryan and the Patriots, but it backfired in Week 2, and that was at home. The Patriots won't take their foot off the gas on Monday Night Football.

Injuries
The Bills don't have any new major injuries to report. They were hoping that DT Kyle Williams would be able to return from a knee injury that has kept him on the sideline since Week 6, but they don't think he'll be ready. But after dealing with a slew of injuries, the Bills seem to be pretty healthy.

One week after losing RB Dion Lewis to a season-ending knee injury, the Patriots lost WR Julian Edeman to a foot injury. They're hoping he can be back for the playoffs, but he definitely won't be back this week. However, it's the Patriots, which means next man up and no coach in the league is better at this than Bill Belichick. Elsewhere, LB Jamie Collins has an illness that has him listed as questionable, while WR Keshawn Martin is also questionable with a hamstring injury.

Trends
The Bills are 5-4 ATS this season, and they've covered in three of their four road games. The Patriots are 5-2-2 ATS, and they're 3-0-2 ATS at home. The total opened at 49.5 and has moved down to 48, and both teams have gone over five times this season.

The Patriots have dominated this AFC East matchup recently, going 8-2 SU and 6-4 ATS in their last 10 meetings with the Bills. At home, New England is 9-1 SU in their last 10 games with the Bills, who have covered in six of those games.