Is it stuck at the Initializing screen? If it is it's most likely your anti-virus program blocking it.

You'll need to add exceptions for CCRBridge.exe, Cricut-Craftroom.exe. You'll find CCRBridge.exe in two locations on your hard drive. Make sure you add both just to be sure. One is in C:/Program Files/Cricut-Craft Room and the other is in C:/Program Files/Cricut Sync.

If that doesn't help you can also try running it in compatibility mode. Here's a screen shot of what you need to select.

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