Contrast Ultrasound of the Small Intestine in Patients With Crohns Disease (KULT)

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The purpose of this study is to determine how relevant dynamic ultrasound scans using contrast agents (SonoVue) is in the diagnosis of Crohns disease in the small bowel, compared to dynamic Magnetic Resonance Imaging (MRI) of the small bowel.

Condition or disease

Crohn Disease

Detailed Description:

Crohns disease (CD) is a lifelong chronic Inflammatory Bowel Disease (IBD) normally with an early debut. It requires continuous evaluation with either endoscopy, Magnetic Resonance Imaging (MRI), Computed Tomography (CT) or Wireless Capsule Endoscopy (WCE). These methods are either expensive, invasive or with uses radiation. Therefore UltraSound (US), as a cheap, fast and well tolerated examination of the small bowel are tested against the the validated MRI examination of the small bowel. Both examinations are using intra venous (i.v.) contrast agents. Obtained results are compared to disease activity.

Hypothesis is, that dynamic US is comparable to dynamic MRI and therefore should be the first examination of choice in evaluating patients with CD.

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Ages Eligible for Study:

18 Years and older (Adult, Senior)

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

No

Sampling Method:

Non-Probability Sample

Study Population

Patients treated on Regional Hospital of Silkeborg.

Criteria

Inclusion Criteria:

Patients with known Crohns Disease

18 years old or older.

Referred to a Magnetic Resonance Imaging scan of the small bowel

Exclusion Criteria:

Contraindications to or not suitable of a Magnetic Resonance Imaging

Liver transplant

nursing og pregnancy

Known Allergy of SonoVue

Acute Myocardial infarction < 4 weeks

Coronary angiography < 4 weeks

Electrocardiogram changes < 4 weeks

frequent and repetitive angina pectoris symptoms within the last week.