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When it comes to mood disorders, major depression has dominated the headlines. Diagnosis of major depression requires that the patient have at least 5 of 9 criterion symptoms (1 of which must be depressed mood or anhedonia) nearly every day for 2 or more weeks. Attracting somewhat less attention, dysthymia is a chronic disorder that manifests as depressive symptoms that persist more days than not for several years. Diagnosis of dysthymia does not require at least 5 symptoms, unlike major depression. Minor depression has been the Cinderella of the 3 conditions: The diagnosis requires neither meeting the symptom threshold of major depression nor the chronicity threshold of dysthymia. Mood disorder research has corresponded to this rank ordering. Therefore, clinicians have a rather robust evidence-based approach to the management of major depression, a more modest understanding of what to do for the patient with dysthymia, and even fewer data to guide them in caring for the patient with minor depression.