If Father Time plans to chase down Frank Gore this season, it sure wasn't apparent in the season-opening victory over Green Bay.

Gore turns 30 in May, an age at which many running backs falter or break down physically. The 49ers invested in protection at the position by signing Brandon Jacobsand drafting LaMichael James to join Kendall Hunter in a suddenly crowded backfield.

Then, in the opener, Gore promptly rumbled for 112 yards on 16 carries, including a 23-yard touchdown run. It was the most productive opener of his eight-year career, as he became the first 49ers player to eclipse 100 yards rushing in the opener since Garrison Hearstgained 187 against the Jets in 1998.

Coach Jim Harbaugh offered high praise Friday, comparing Gore to the man known as "Sweetness."

"Frank is one of the best there is," Harbaugh said. "I thought his touchdown run in Green Bay, staying inbounds the way he did, reminded me of a Walter Paytonclip on the sideline at Green Bay where he didn't go out of bounds."

Gore brings some positive history into Sunday night's game against Detroit. He gained a season-high 141 yards on 15 carries when the 49ers beat the Lions last year in the Handshake Game.

Injury update: Jacobs (knee injury) and wide receiver Ted Ginn Jr. (ankle) missed practice again Friday, even if Harbaugh said of their potential availability, "They're getting darn close. We might have a shot this week."

Notable numbers: The 49ers have won their past eight games against the Lions and haven't lost to Detroit since 1995. The Lions have dropped their past 11 games at Candlestick Park, where they haven't won in nearly 37 years (Nov. 2, 1975).