Wilson ran a kickoff back 97 yards for a touchdown and rushed for two more scores and 100 yards on 13 carries. Eli Manning went 22-of-35 for 259 yards and four touchdowns and Victor Cruz made eight catches for 121 yards and a score for the Giants (8-5), who maintained their one-game lead over the Dallas Cowboys in the NFC East.

Darren Sproles rushed for a score and caught another but Drew Brees was picked off twice and the Saints (5-8) totaled four turnovers in their third straight setback.

Things did not start off so well for Manning, who had an interception returned 73 yards for a touchdown by Elbert Mack with 9:54 left in the first quarter. But Wilson ran the ensuing kickoff back for the touchdown and Manning turned New Orleans’ second fumble in as many series into a touchdown with a 6-yard strike to Martellus Bennett that gave the Giants the lead.

5-yard scoring pass to Domenik Hixon made it a 21-13 lead at the break, and Brees was picked off on his first pass attempt of the second half, leading to Wilson’s 6-yard rushing score. It would stretch out to 35-13 before Sproles got the Saints back into it with two TDs to cut the deficit to 35-27, but Manning found Cruz early in the fourth quarter and Wilson put it away on a 52-yard scamper with 5:20 left.

The win allowed the Giants (8-5) to maintain their one-game lead in the NFC East over Washington and Dallas. The loss all but ended the playoff hopes of Drew Brees and the Saints (5-8).