N-Tidal Sensor

Working closely with our shareholder partner, Gas Sensing Solutions, we have developed an innovative, low-cost, low-power sensor to accurately measure CO2 in normal tidal breathing. Our sensors are based on advanced III-V LED technology and use an emitter detector pair refined to work in the technically challenging 4.3µm light frequency. By using advanced epitaxially-grown semiconductor technology and simplifying the optical path we have avoided the use of costly beam splitters and rotating filters.

Developed to be more accurate, stable and sensitive than earlier generation CO2 sensors, CRiL’s CO2 sensor platform is also the fastest sensor available. It delivers unrivalled accuracy throughout the range of respired CO2, including at low CO2 levels. Our sensor has been designed and configured specifically to capture the user’s tidal breathing waveform. Variants of this sensor will be used in both the personal respiratory monitors and the advanced diagnostic devices. Whilst detailed respiratory information can be provided to the medical professional, in all of our N-Tidal devices the sensor has been combined with advanced algorithms and analytics to provide clear and easy to interpret results for the individual user.

CRiL has already filed two patent applications to protect its novel technology.

N-Tidal Monitors

Our N-Tidal personal respiratory monitors are designed to be used by the patient to assess their current respiratory condition by analysing normal tidal breathing. There is no requirement for any forced expiration. They are easy and simple to use. Because they only require normal tidal breathing, all ages and respiratory conditions can use our technology.

Our first personal respiratory monitor, the N-Tidal C, is a CE marked Class I device and has already been used in a pivotal clinical study with patients with COPD. It takes just 75 seconds of normal tidal breathing to collect an accurate breathing record to give a clear indication of the current state of respiratory performance.

Our N-Tidal B personal respiratory monitors will immediately analyse the changing shape of the tidal breathing CO2 waveform and provide the patient with an advance alert of deterioration towards an exacerbation. This will allow medical intervention to prevent the exacerbation.

N-Tidal System

Our N-Tidal monitors are designed to provide alerts and respiratory performance data to those who need it, when they need it.

·Our low-cost N-Tidal personal respiratory monitor is quick and easy to use. The patient just breathes through the device for about 75 seconds via the disposable mouth piece.

·The N-Tidal monitor records the TBCO2 waveform and analyses it locally. The patient then receives a green, amber or red light to indicate the state of their lung function, and refers to their personalised clinically-led self-management plan.

·The respiratory data is then transmitted to the ‘cloud’ to the main database where further data analysis and machine learning is undertaken.

·Key alerts are sent to clinicians and carers. Detailed respiratory data is available to the clinician and as part of the ‘Big Data’ set.