Background: Legionella pneumophila is a pathogenic bacterium that can cause Legionnaires’ disease and other non-pneumonic infections in humans. This bacterium produces a pyomelanin pigment, a potential virulence factor ...

We have studied phospholipase D (PLD) in human blood platelets. This enzyme hydrolyzes
phosphatidylcholine to phosphatidic acid (PA) and choline, where PA is considered to be the
main effector of PLDs function in cells. ...

Lellahi, Seyed Mohammad(Master thesis, The University of Bergen, 2014-06-02)

Gliomas are tumors of the central nervous system
(CNS). They are responsible for about 28% of all
central nervous system tumors and for 80% of all
malignant brain tumors. The most commonly used
classification and grading ...

Influenza is a highly contagious respiratory disease which infects millions of people every year around the world. Influenza viruses undergo continuous antigen change and annual vaccination is an effective prophylactic ...

Precise annotation of genes or open reading frames is still
a difficult task that results in divergence even for data
generated from the same genomic sequence. This has an
impact in further proteomic studies, and also ...

Background: Tumor interstitial fluid (TIF) rather than plasma should be used in cancer biomarker discovery
because of the anticipated higher concentration of locally produced proteins in the tumor microenvironment.
...

Background: Rheumatic joint pain is a common extraintestinal complication of inflammatory bowel disease (IBD). Because the high ratio of n-6 to n-3 fatty acids (FAs) of the Western diet might promote rheumatic disorders, ...

Background: Hypoxia- and Myc-dependent transcriptional regulatory pathways are frequently deregulated in cancer cells. These pathways converge in many cellular responses, but the underlying molecular mechanisms are ...

Background: The regulatory subunit (R) of cAMP-dependent protein kinase (PKA) is a modular flexible protein that responds
with large conformational changes to the binding of the effector cAMP. Considering its highly dynamic ...

Mkonyi, Lilian E.(Doctoral thesis, The University of Bergen, 2012-05-25)

Background: The gingiva is frequently challenged to oral bacteria which are able to
induce inflammatory responses with increased fluid filtration and edema formation in
the tissue. Under given circumstances periodontal ...

Kouprina, Nina Vladimirov(Master thesis, The University of Bergen, 2011-06-01)

The biosynthetic-secretory pathway delivers newly synthesized molecules from the endoplasmic reticulum (ER) to the plasma membrane (PM), as well as to endomembrane compartments. The intermediate compartment (IC) is an ...

Heparan sulphate (HS) proteoglycans, composed of a core protein and one or more
negatively charged HS chains, are a major component of extracellular matrices and
are located on the plasma membrane of all animal cells. ...