Since this book is non-fiction and is an actual account of James Watson, the plot is a mixture between his quest to find the structure of DNA, and his personal engagements. Throughout the book he talks about going to different parties or lectures. When he is at work he works with Francis Crick on the structure. It also talks a little about how he got to Cambridge and the places he went along the way. Basically, the plot of the story is the quest of a scientist to complete his goals and live his life.