ads were evaluated and representative samplesof lung tissues were ana...Examination of the lungs revealed evidence of a dose-relatedreduction...The study results are being presented at the ongoing 2ndInternational...Recent medical reports from critical influenza regions such asSouthea... The threat of global pandemic illness from infectious diseaseputs th...

ads were evaluated and representative samples
of lung tissues were analyzed for pathologic changes.

Examination of the lungs revealed evidence of a dose-related
reduction of infection-related pneumonia. Two of the three animals
in the highest dosing group showed no evidence of lung infection to
the naked eye, while lower-dose groups did show visible infection.
This dose-related response was noteworthy given that viral loads
were consistent among the subjects receiving the various dosages
and the control group. Ten days of ongoing Alferon-LDO prophylaxis
and treatment reduced the severity of pneumonia despite the
continuing presence of the influenza virus.

The study results are being presented at the ongoing 2nd
International Conference on Avian Influenza, being held at the
Pasteur Institute.

Recent medical reports from critical influenza regions such as
Southeast Asia indicate that presently available therapies, even
given at the highest doses available via intravenous routes, do not
alter the avian influenza death rate, which at present is greater
than 60%. Given the danger of an avian flu pandemic, the lack of an
effective available therapy and the fact that Alferon-N(TM) is
already approved by the United States FDA as safe and effective in
treating a different virus, Hemispherx management is hopeful that
Alferon-LDO can receive expedited review and emergency-based
approval as an anti-HPAI agent, solely relying on the "animal rule"
for demonstration of efficacy.

"The threat of global pandemic illness from infectious disease
puts the highest possible priority on finding therapeutic
strategies that can protect first responders and save patient
lives," commented Dr. William Carter, Chairman and Chief Executive
Officer of Hemispherx. "We are encouraged by the strong potential
that Alferon-LDO, an experimental formulation of our previously
licensed drug, shows as a prophylactic agent, especially for
front-line health care workers, and its ad'"/>

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