Co-sponsored by the Section of Pulmonary and Critical Care Medicine and the Department of Medicine, Geisel School of Medicine at Dartmouth

Objectives – Participants will be able to:

Understand the methods and challenges of finding genes for complex diseases

Discuss the genetics and natural history of alpha 1-antitrypsin deficiency

Summarize the evidence for novel genetic influences in COPD

Edwin K. Silverman, MD, PhD

Dr. Edwin Silverman is a pulmonologist and genetic epidemiologist whose research focuses on the genetics of chronic obstructive pulmonary disease. He is the Principal Investigator of multiple studies of COPD genetics, including the Boston Early-Onset COPD Study, the Alpha 1-Antitrypsin Genetic Modifiers Study, the NETT Genetics Ancillary Study, and the Transcontinental COPD Genetics Study. He is also one of two Principal Investigators of the COPDGene Study. His recent work has focused on the identification of functional genetic variants influencing COPD susceptibility and on integrating imaging, physiology, clinical characterization, and genetics to identify COPD subtypes. He is a Professor of Medicine at Brigham and Women’s Hospital and Harvard Medical School, and he is the Chief of the Channing Division of Network Medicine at Brigham and Women’s Hospital.

Edwin K. Silverman, MD, PhD has disclosed possible conflicts of interest, which have been resolved by the Chair through an independent peer review of the presentation’s content. Edwin K. Silverman, MD, PhD is a consultant for Merck and Glaxo, Smith & Kline. These conflicts have been resolved by the Chair through an independent peer review of the presentation’s content.

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*PLEASE NOTE: Credit will only be awarded for written evaluations submitted within 1 week of conference date.

** The Dartmouth-Hitchcock Medical Center is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education programs for physicians.**

** The Dartmouth-Hitchcock Medical Center designates this live activity for a maximum of 1 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity. **