I ask, because I have a different interpretation of the experiments performed on web-weaving spiders. The famous Robert Pirsig maintains that LSD is somehow helpful to web-weaving spiders, because it ...

Does anyone know of any experimental work to test the permeability of the hyaloid membrane between the vitreous humour of the eye to the retina to proteins? Currently the largest molecule I can find ...

Let's assume we have two toxins - one of which is routinely metabolized by the liver, and the other is new to the organism (consider for example alcohol in a heavy drinker and any other drug that is ...

Potassium channels help to repolarize the cell after depolarization. But if the potassium channels are blocked, potassium ions cannot flow out of the cell to increase the membrane potential. Thus, one ...

I'm not a biologist but I have an idea for a cure for cancer and it is very simple and probably has flaws (if it worked it probrably wouldn't be a cure for all) or is not possible but ... I'm still ...

My question is regarding the biological nature of the separation between the vitreous humour and aqueous humour of the human (or mammal) eye. What connects the two in terms of the passive transport of ...

I have a dataset containing IC50 data for each of my cell lines and up to 80 drugs. Basically for each drug I want to be able to define an IC50 threshold where if a cell line has an IC50 above that ...

I have heard from many homeless people that they sniff glue just to reduce appetite, as it comes cheap and is more affordable than actual food.
Is this true, and if yes, why? This is totally opposite ...

I wanted to buy black tea at a pharmacy and the pharmacist told me that russian tea is actually black tea so I bought it instead.It's made out of theae folium leaves and for some reason I can't find ...

Are psychoactive drugs with lower lethal doses more neurotoxic (more damaging to the brain)? For example, tetrahydrocannabinol (one of the active components of cannabis) has a much higher lethal dose ...

According to the book "Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy" by Golan et al, non-competetive antagonists can bind to both the allosteric site and the active site.
I ...

I am a medicine student, and as far as I see from our pharmacology lectures, pharmacologists work almost completely experimental. Quite typically they take a substance (e.g., from nature), they add, ...

All-trans retinoic acid (atRA) is a potent ligand for a nuclear receptor called retinoic acid receptor alpha (RARa). The concentration of atRA at which RARa is half maximal is 19nM. The dose-response ...

Our bronchus and uterus has beta adrenoreceptors, but they have no active sympathetic nervous system innervation in these organs. Was there a sympathetic innervation in trachea and uterus, earlier, ...

For example, when one takes aspirin or ibuprofen does the chemical get dispersed to all pain receptor? My question really is, how does the chemical know where to target in the body? I figure wherever ...

I reading that orsomucoid (alpha-1-acid glycoprotein) is the major carrier of positively charged (basic) drugs in the blood, while albumin carries negatively charged (acidic) and drugs with neutral ...

I have seen on the internet that prolonged steriod treatment can result in the development of steroid drug tolerance leading to decreased hormone secretion. In turn this may lead to drug dependence, ...

I have had a look at previous inhaled anesthetics and many of them appear to be fluorocarbons. What could be the mechanism behind fluorine's anesthetic properties? Is it the specific bonding pattern ...

They are nonselective cholinoblockers and antimuscarinic.
Other cholinoblockers of parasympaticus, which I know, are parasympatholytic such as atropine, butylscopolamine, trihexyphenidyl, titropium ...

Norepinephrine is less beta2 adrenomimetic than epinephrine so more selective so less bronchospasm so may be therofore better in treatment of cardiac failure and different shocks.
However, I am not ...

Assume you have a drug nebivolol.
When nebivolol is used as beta1 selective drug, beta2 is mostly for side effects, but this is not clear from PubChem.
I do not know any cases where nebivolol is used ...

I've researched quetiapine for quite some time now and I've found some references to tolerance, but nothing conclusive. My question is whether quetiapine use builds tolerance to the drug and if so, ...