Rassia, please stop posting links to website promoting commercial interests. If you'd like to have a discussion of the science behind those treatments, this is the place to do so. If you'd rather promote someone's commercial interests, please take it elsewhere.

Rassia, yes those are POIS symptoms. Again I ask you: Are you cured? Which treatments relieved which symptoms? How long have these treatments been working to resolve your symptoms and how long did you have to take them before they began working?

Sorry if I sound aggressive, but if you've found something that is helping your POIS I hope you'll share with us specifically what herb/supplement/treatment protocol or medication it is.

I cant remember the logic given by that doctor who initially recommended niacin to dampen down pois symptoms, but I have been reading some site regarding MTHFR mutation, and I see people on the protocols to stabilize or kick start their methylation cycle (Detoxification + Controlling inflammation + Mood balancing + Energy production + Immune function), use Niacin to create the flush to deal with symptoms caused by taking too much of their supplements and causing over methylation. (the symptoms are not too dissimilar to pois I thought)

From a doctor specialising in MHTR + methylation...."Niacin speeds up COMT which is one reason why it also may be useful. If one speeds up COMT, then things like dopamine and epinephrine get broken down faster. Niacin also is a ‘sponge’ for methyl groups, namely SAMe, because SAMe is required to metabolize niacin." COMT is Catechol-O-Methyltransferase enzyme.I know this goes against a number of us who feel we are low in dopamine. I can understand why our body is flooded with it during sex/arousal, but why if it is not broken down properly it would it make up feel days later like we are low in it.

From a doctor specialising in MHTR + methylation...."Niacin speeds up COMT which is one reason why it also may be useful. If one speeds up COMT, then things like dopamine and epinephrine get broken down faster. Niacin also is a ‘sponge’ for methyl groups, namely SAMe, because SAMe is required to metabolize niacin." COMT is Catechol-O-Methyltransferase enzyme.I know this goes against a number of us who feel we are low in dopamine. I can understand why our body is flooded with it during sex/arousal, but why if it is not broken down properly it would it make up feel days later like we are low in it.

I got my 23andme results. I have heterozygous C677T and A1298C mutations to the MTHFR gene. Chances of me being "over-methylated" without supplementation seem very low.

Actually my COMT genes appear completely normal. i.e. no mutations at all based on what I saw on SNPedia so I can take more dopamine production without any problems and could handle methylfolate and methyl b12. Unfortunately, I seem to be a carrier for hemochromatosis and have a bunch of CBS mutations. The end result, it makes sense why methionine makes me feel better but gives me an upset stomach and I have to watch my folate intake carefully. Perhaps it's not active but it gave me pause for thought.

Hi Nomore2013, here is my answer to your question. So I began to take flunarizine on november 19th. Yesterday december 21th I had an O at 20 o'clock. I went to sleep at 22 o'oclock and I woke up this morning at 9 o'clock. I had some POIS symptoms this morning. But very ligth symptoms. A little brain fog, fatigue, a little irritable. I could say that by 13 o'clock today, every symptoms are gone. Flunarizine is very efficient whith me. I must say that I am a anxious person since I was born. And I must take citalopram since many years now. Since I'm taking flunarizine, I have to sleep more. Flunarizine give me a fatigue that I didn't have before. This fatigue getting lighter each day since the begining of the treatement. Otherwise, I could say that I'm very satisfied whith flunarizine. I'M wondering if that fatigue come from the combinaison of taking citalopram and flunarizine. My doctor told me that flunarizine can take 8 weeks to be full efficient. I'M this only patient having POIS so he don't know this desease. He is convinced that is the sides effects of flunarizine making me fell good after an O. I'm seeing my doctor on january 21th. He is discovering POIS and the treatement whit me. I'M so happy of these results that I would recommand to everybody try this treatement but I know that everybody have to be carefull whit drugs.

And I must say that usually it takes me 6-7 days to be OK after an O whithout flunarizine. Also, my doctor told me that the fatigue cause by flunarizine should disappear after 2 or 3 month of the treatment

Yes, I've also read about prolactinaemia and came to conclusion that symptoms match quite closely and was interested in it for a while, but everywhere it's written that tumor is required to be present..

A few of us have gotten our DNA analyzed. In fact, there have been three of us in total so far- kurtosis, nomore2013, and me. CertainlyPOIS is also submitting his saliva for testing soon. There's a lot of benefit to have this testing done, but the main benefit is to eventually have enough data (sample size of 10-20 of us) for a researcher to examine and make inferences with some degree of confidence. Ultimately, the goal is for this researcher to locate specific mutations that we all have in common that could explain pois. With just 3 samples right now we've identified some similarities of certain defects and other issues, but 3 is obviously not enough to draw any conclusions. With some more samples we can get a better picture of all this and try to figure out what it means.

The testing costs btwn $120 and $180 after shipping costs of the saliva sample to the lab. If you think you might be interested in having your dna analyzed and contributing to this project, please shoot me a pm and I can give you some more details. Thanks guys.

Nightingale has told me he's also getting the testing done. In my case, I think the testing is a good idea. I'm feeling better every day taking methylfolate and some other things which help with some obvious methylation cycle impairments revealed by genetic testing.

As i read in Dr's Waldinger announcement he said that when the semen is in the testis there is no problem and only after an ejaculation the symptoms began.In my case things are slightly different..Yes i have the POIS symptoms after an O (mostly mental symptoms) but the weird thing is that there is no symptom after an nocturnal emission..I dont get it..Nocturnal emission is an ejaculation right ? So why there are no symptoms after this

Hi chris 18. Nocturnal emissions caused less symptoms for me because they occurred during sleep which is a healing time. Perhaps this is what is happening in your case as well.

About niacin, it is true that many of our members have benefited from this vitamin including myself. Most of the discussion about it has been at our main forum at poiscenter.com. Here is one post that partly describes our usage of niacin for POIS: http://poiscenter.com/forums/index.php?topic=75.msg692#msg692

There is a specific protocol you must follow if you want to use niacin for POIS. The first step is buying the right kind (nicotinic acid) and making sure that it is not the "no-flush" type. Also make sure it is not niacinamide or slow-release. We have had the greatest benefit with the flush type so you will want to have the niacin flush, which is a hot-itchy feeling in your skin and your skin will turn reddish for a short period. It's safest to start with 50mg if you are concerned about this flush. Most of our members need about 200mg to get the flush. You should take the dose about an hour before orgasm and wait for the flush to happen about half an hour later and orgasm as the flush is beginning to die off or just after it goes away.

If you can't get a flush with 200mg then you will need to fast for about 5 hours prior to dosage to make sure you take it on an empty stomach. After your niacin arrives immediately wrap it in plastic or something air-tight or else it will become less effective - For instance I didn't wrap mine up even though I always closed the bottle and after a few months I now need 500mg to flush where as originally I only needed 200mg. Taking it more often will cause tolerance and probably make it less effective as well, but I've only taken it a few times over the past year so I haven't had that problem.

Taking niacin after an orgasm usually doesn't help much for us. So you will want to take it before an orgasm as I described above.

The flush is considered completely safe and you can google "niacin flush" to verify this. There is a slight concern of liver damage, but doctors sometimes prescribe up to 1,000mg of niacin daily for short periods to lower cholesterol so I'm sure that taking 200-400mg once a week would be completely fine.

As i read in Dr's Waldinger announcement he said that when the semen is in the testis there is no problem and only after an ejaculation the symptoms began.In my case things are slightly different..Yes i have the POIS symptoms after an O (mostly mental symptoms) but the weird thing is that there is no symptom after an nocturnal emission..I dont get it..Nocturnal emission is an ejaculation right ? So why there are no symptoms after this

Hi chris 18. Nocturnal emissions caused less symptoms for me because they occurred during sleep which is a healing time. Perhaps this is what is happening in your case as well.

About niacin, it is true that many of our members have benefited from this vitamin including myself. Most of the discussion about it has been at our main forum at poiscenter.com. Here is one post that partly describes our usage of niacin for POIS: newbielink:http://poiscenter.com/forums/index.php?topic=75.msg692#msg692 [nonactive]

There is a specific protocol you must follow if you want to use niacin for POIS. The first step is buying the right kind (nicotinic acid) and making sure that it is not the "no-flush" type. Also make sure it is not niacinamide or slow-release. We have had the greatest benefit with the flush type so you will want to have the niacin flush, which is a hot-itchy feeling in your skin and your skin will turn reddish for a short period. It's safest to start with 50mg if you are concerned about this flush. Most of our members need about 200mg to get the flush. You should take the dose about an hour before orgasm and wait for the flush to happen about half an hour later and orgasm as the flush is beginning to die off or just after it goes away.

If you can't get a flush with 200mg then you will need to fast for about 5 hours prior to dosage to make sure you take it on an empty stomach. After your niacin arrives immediately wrap it in plastic or something air-tight or else it will become less effective - For instance I didn't wrap mine up even though I always closed the bottle and after a few months I now need 500mg to flush where as originally I only needed 200mg. Taking it more often will cause tolerance and probably make it less effective as well, but I've only taken it a few times over the past year so I haven't had that problem.

Taking niacin after an orgasm usually doesn't help much for us. So you will want to take it before an orgasm as I described above.

Here is a post that summarized each individual member's experience with niacin (Recorded are 21 positive experiences and 6 negative): newbielink:http://poiscenter.com/forums/index.php?topic=235.msg2958#msg2958 [nonactive]

The flush is considered completely safe and you can google "niacin flush" to verify this. There is a slight concern of liver damage, but doctors sometimes prescribe up to 1,000mg of niacin daily for short periods to lower cholesterol so I'm sure that taking 200-400mg once a week would be completely fine.