You can actively contribute to the development of the IARC TP53 Database by submitting data directly to us at
.
At the present time we only accept data that have been accepted for publication in peer-reviewed journals.
Mutation must be described at the nucleotide level.

To submit data, you may use the IARC submission forms:
download forms.

You may submit data using hg19 or hg38 genome build. We recommend using NM_000546 reference transcript.

To convert position of mutations from g. to c. or between different genome builds, we recommend to use Mutalizer.

Reporting in scientific journals

When reviewing published papers for updates of the database, we encounter several problems:

editing errors: errors in the identification of codon numbers and base sequences are frequent;

duplicates: some series of samples are reported in several papers without reference to previous publications;

loss of data: many interesting studies on big series of
patients are not included in the database because the publications do not provide detailed information on each
mutation detected but rather report results in the form of summary tables or graphs;
In 2007, we have estimated that more than 5000 mutations
(20% of all reported data) could not be included in the database.

loss of information: it is very frequent that the information on patients (age, sex...) and samples (histology,
grade, stage) is summarized in a descriptive table and cannot be captured in the database.

To avoid these problems, we recommend that authors:

(1) clearly identify each re-cited mutation to avoid redundancies in the database;

(2) provide unique identifiers for tumor samples;

(3) check codon and nucleotide numbers with the tool described above;

(4) use HGVS nomenclature to describe mutations;

(5) when available, provide details on tumor samples (site, histology, grade, stage), patient characteristics (age, sex,
ethnicity, country of origin, clinical records) and individual exposures to cancer risk factors (tobacco, alcohol, chemicals,
....). If this information cannot be included in the original publication, it can be directly submitted to
.

We may contact authors to obtain their active collaboration in data collection.

We encourage authors to reply to those requests. In 2007, we have estimated that at least 5000 mutations (around 20% of the data
published) could not been entered in the database because no details on mutations could be extracted from the original papers
. These data are thus lost for meta-analysis.

It would be most useful if publishers and editors could collaborate with the database and request that authors of accepted publications deposit their data
in the IARC TP53 Database. A link to the IARC dataset could then be included in the publication as "supplementary data".
This strategy would allow journals to avoid publishing long tables giving the details of all mutations reported.