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Conclusion #3 — MPL Exon 10 Sequencing

October 2011

Our third conclusion today: Only selective patients with possible MPNs should be sequenced for a MPL mutation. Physicians will frequently order MPL exon 10 sequencing when it is not needed in the evaluation of a patient with a possible myeloproliferative neoplasm. And finally, MPL exon 10 sequencing should be limited to patients with negative JAK2 studies and borderline bone marrow morphologic studies as we have talked about previously.