Cameron Esposito, Rhea Butcher

It's hard to believe that four wild years have passed since the clip of Cameron Esposito riffing with Jay Leno on The Late, Late Show With Craig Ferguson went viral. Esposito made the most of that momentum, though, eventually landing her own show on SeeSo, Take My Wife, which sitcom-ified her exploits with her real-life wife Rhea Butcher, as they navigate the world of comedy and their relationship. They're a legitimate LA comedy power couple, and their weekly podcast Put Your Hands Together is required listening for comedy nerds. Often times the podcast's episodes peak with the two comics loosely riffing through crowd work at the top of the show. Expect a bit of that, along with some finely honed prepared material, when the duo wraps up their cross-country co-headlining "Back To Back" comedy tour here. —Chris Lay