Research Resources

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Resources listed below (reagents, data, protocols, etc.) are derived from publicly available information provided by NIDDK-funded investigators, projects, and publications. Many clinical resources listed are available through the NIDDK Central Repository​. Please direct inquiries to the contact provided for each resource.

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Evaluating Predictors and Interventions in Sphincter of Oddi Dysfunction
(EPISOD)

The EPISOD study is a prospective, double-blind, randomized, sham-controlled, multi-center clinical trial. The EPISOD study enrolls subjects who have received a prior cholecystectomy and are diagnosed with the clinical syndrome of Sphincter of Oddi…

The Acute Liver Failure Study Group is collecting biosamples and information on the natural history, causes and outcomes of Acute Liver Failure in the United States. In addition to the database, a clinical trial conducted to test whether the drug…

ACCORDION (sponsored by NHLBI) is a prospective, observational follow-up study of at least 8000 participants who were treated and followed in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) Trial. Treatment in ACCORD ended in 2009 and…

The mission of the PROTECT Study is to provide a better understanding of how children newly diagnosed with ulcerative colitis (UC) respond to mesalamine and prednisone (corticosteroid), the standard initial therapies used to treat this disorder…

The mission of the ISCC is to advance the understanding of intestinal epithelial stem cell biology during development, homeostasis, regeneration and disease. The immediate goals of the ISCC are to isolate, characterize, culture and validate…

LIFE-Moms is a consortium comprised of seven clinical centers, a Research Coordinating Unit and NIH program staff. The overall goal of the Consortium is to identify effective behavioral and lifestyle interventions that will improve weight, glycemic…

Cre-recombinase under the control of mouse mammary tumor virus long terminal repeat (MMTV) was expressed in the salivary gland and mammary epithelial cells of adult mice, and induced recombination in all tissues.

Cre-recombinase under the control of the whey acidic acid protein was only detected in alveolar epithelial epithelial cells of mammary tissue during lactation, and transcription occurred at all stages of mammary development.

Sphingosine kinase 1 and 2 are enzymes that produce sphingosine-1-phosphate (S1P), a potent bioactive compound that activates a family of G-protein coupled receptors known as S1P receptors. Triggering…

Atherosclerosis is the underlying cause of coronary artery disease, the number one cause of death in the United States. It is a slowly progressing chronic disease in which cholesterol deposition, invasion of monocytes and smooth muscle cells, and…

This invention, offered for licensing and commercial development, relates to a new class of naturally occurring antimicrobial compounds called Chrysophaetins, and to their synthetic analogues. Isolated from an alga species, the mechanism of action of…

Personalized Body Weight Management System Using Monitoring Devices and Mathematical Models of Metabolism

Attempts to manage body weight are often unsuccessful or only temporary. This is, in part, due to antiquated dieting methods that attempt to address calorie consumption while ignoring metabolic and physical changes. It is becoming clear that…

mEpoR-/- hEpoR+: The mouse Erythropoietin Receptor knockout that contains a human Erythropoietin Receptor transgene can be used to define the potency of recombinant erythropoietin preparations used to treat anemia associated with chronic kidney…