Hope you could help me with this. I have set up Reporting Services and when I've tried accessing the Report Manager, I can see all the created Folders and uploaded RDL files. However, when I've tried to make changes in a shared data source, it won't allow the changes and throws up the error:

"An internal or system error occurred in the HTTP Runtime object for application domain ReportManager_MSSQLSERVER_0-1-130186043382179983"

It also shows up when I've tried to upload new RDL files. I have also checked the log files and here are the details:

<Header> <Product>Microsoft SQL Server Reporting Services Version 2009.0100.1600.01 ((KJ_RTM).100402-1539 )</Product> <Locale>English (United States)</Locale> <TimeZone></TimeZone> <Path>C:\Program Files\Microsoft SQL Server\MSRS10_50.MSSQLSERVER\Reporting Services\Logfiles\ReportServerService__07_18_2013_17_00_47.log</Path> <SystemName>APPSSERVER</SystemName> <OSName>Microsoft Windows NT 6.1.7601 Service Pack 1</OSName> <OSVersion>6.1.7601</OSVersion> <ProcessID>4044</ProcessID> <Virtualization>Hypervisor</Virtualization></Header>rshost!rshost!f68!07/18/2013-17:00:47:: i INFO: CLR runtime is initialized.rshost!rshost!f68!07/18/2013-17:00:47:: i INFO: Derived memory configuration based on physical memory as 8388152 KBappdomainmanager!DefaultDomain!1040!07/18/2013-17:00:47:: i INFO: Entered managed ServiceMain in DefaultDomain.library!DefaultDomain!dcc!07/18/2013-17:00:47:: i INFO: Initializing ConnectionType to '0' as specified in Configuration file.library!DefaultDomain!dcc!07/18/2013-17:00:47:: i INFO: Initializing SecureConnectionLevel to '0' as specified in Configuration file.library!DefaultDomain!dcc!07/18/2013-17:00:47:: i INFO: Initializing CleanupCycleMinutes to '10' minute(s) as specified in Configuration file.library!DefaultDomain!dcc!07/18/2013-17:00:47:: i INFO: Initializing MaxActiveReqForOneUser to '20' requests(s) as specified in Configuration file.library!DefaultDomain!dcc!07/18/2013-17:00:47:: i INFO: Initializing DatabaseQueryTimeout to '120' second(s) as specified in Configuration file.library!DefaultDomain!dcc!07/18/2013-17:00:47:: i INFO: Initializing RunningRequestsScavengerCycle to '60' second(s) as specified in Configuration file.library!DefaultDomain!dcc!07/18/2013-17:00:47:: i INFO: Initializing RunningRequestsDbCycle to '60' second(s) as specified in Configuration file.library!DefaultDomain!dcc!07/18/2013-17:00:47:: i INFO: Initializing RunningRequestsAge to '30' second(s) as specified in Configuration file.library!DefaultDomain!dcc!07/18/2013-17:00:47:: i INFO: Initializing MaxScheduleWait to '5' second(s) as specified in Configuration file.library!DefaultDomain!dcc!07/18/2013-17:00:47:: i INFO: Initializing DisplayErrorLink to 'True' as specified in Configuration file.library!DefaultDomain!dcc!07/18/2013-17:00:47:: i INFO: Initializing WebServiceUseFileShareStorage to 'False' as specified in Configuration file.library!DefaultDomain!dcc!07/18/2013-17:00:47:: i INFO: Initializing WatsonFlags to '1064' as specified in Configuration file.library!DefaultDomain!dcc!07/18/2013-17:00:47:: i INFO: Initializing WatsonDumpOnExceptions to 'Microsoft.ReportingServices.Diagnostics.Utilities.InternalCatalogException,Microsoft.ReportingServices.Modeling.InternalModelingException,Microsoft.ReportingServices.ReportProcessing.UnhandledReportRenderingException' as specified in Configuration file.library!DefaultDomain!dcc!07/18/2013-17:00:47:: i INFO: Initializing WatsonDumpExcludeIfContainsExceptions to 'System.Threading.ThreadAbortException,System.Web.UI.ViewStateException,System.OutOfMemoryException,System.Web.HttpException,System.IO.IOException,System.IO.FileLoadException,Microsoft.SharePoint.SPException' as specified in Configuration file.library!DefaultDomain!dcc!07/18/2013-17:00:47:: i INFO: Initializing AuthenticationTypes to '5' as specified in Configuration file.library!DefaultDomain!dcc!07/18/2013-17:00:47:: i INFO: Initializing RSWindowsExtendedProtectionLevel to 'Off' as specified in Configuration file.library!DefaultDomain!dcc!07/18/2013-17:00:47:: i INFO: Initializing RSWindowsExtendedProtectionScenario to 'Proxy' as specified in Configuration file.library!DefaultDomain!dcc!07/18/2013-17:00:47:: i INFO: Initializing EnableAuthPersistence to 'True' as specified in Configuration file.library!DefaultDomain!dcc!07/18/2013-17:00:47:: i INFO: Initializing IsSchedulingService to 'True' as specified in Configuration file.library!DefaultDomain!dcc!07/18/2013-17:00:47:: i INFO: Initializing IsNotificationService to 'True' as specified in Configuration file.library!DefaultDomain!dcc!07/18/2013-17:00:47:: i INFO: Initializing IsEventService to 'True' as specified in Configuration file.library!DefaultDomain!dcc!07/18/2013-17:00:47:: i INFO: Initializing PollingInterval to '10' second(s) as specified in Configuration file.library!DefaultDomain!dcc!07/18/2013-17:00:47:: i INFO: Initializing WindowsServiceUseFileShareStorage to 'False' as specified in Configuration file.library!DefaultDomain!dcc!07/18/2013-17:00:47:: i INFO: Initializing MemorySafetyMargin to '80' percent as specified in Configuration file.library!DefaultDomain!dcc!07/18/2013-17:00:47:: i INFO: Initializing MemoryThreshold to '90' percent as specified in Configuration file.library!DefaultDomain!dcc!07/18/2013-17:00:47:: i INFO: Initializing RecycleTime to '720' minute(s) as specified in Configuration file.library!DefaultDomain!dcc!07/18/2013-17:00:47:: i INFO: Initializing MaxAppDomainUnloadTime to '30' minute(s) as specified in Configuration file.library!DefaultDomain!dcc!07/18/2013-17:00:47:: i INFO: Initializing MaxQueueThreads to '0' thread(s) as specified in Configuration file.library!DefaultDomain!dcc!07/18/2013-17:00:47:: w WARN: Initializing UrlRoot to default value of '' because it was incorrectly specified in Configuration file as ''.library!DefaultDomain!dcc!07/18/2013-17:00:47:: i INFO: Initializing IsWebServiceEnabled to 'True' as specified in Configuration file.library!DefaultDomain!dcc!07/18/2013-17:00:47:: i INFO: Initializing IsReportManagerEnabled to 'True' as specified in Configuration file.library!DefaultDomain!dcc!07/18/2013-17:00:47:: i INFO: Initializing MaxConnections to '2' as specified in Configuration file.library!DefaultDomain!dcc!07/18/2013-17:00:47:: i INFO: Initializing Timeout to '10' second(s) as specified in Configuration file.library!DefaultDomain!dcc!07/18/2013-17:00:47:: i INFO: Initializing AppID to '(Default)' as specified in Configuration file.library!DefaultDomain!dcc!07/18/2013-17:00:47:: i INFO: Initializing CacheLevel to 'Default' as specified in Configuration file.resourceutilities!DefaultDomain!dcc!07/18/2013-17:00:47:: i INFO: Reporting Services starting SKU: Standardconfigmanager!DefaultDomain!dcc!07/18/2013-17:00:48:: i INFO: Using report server internal url http://localhost:80/ReportServer.configmanager!DefaultDomain!dcc!07/18/2013-17:00:48:: i INFO: Using report server external url http://APPSSERVER:80/ReportServer.configmanager!DefaultDomain!dcc!07/18/2013-17:00:48:: i INFO: Using url root http://APPSSERVER:80/ReportServer.rshost!rshost!dcc!07/18/2013-17:00:48:: i INFO: Configuring maxPhysicalCpu=4, minLogicalCpu=0rshost!rshost!dcc!07/18/2013-17:00:48:: i INFO: Logical processor per physical processor 1rshost!rshost!dcc!07/18/2013-17:00:48:: i INFO: Maximum logical CPU is 1configmanager!DefaultDomain!dcc!07/18/2013-17:00:48:: i INFO: Using report server internal url http://localhost:80/ReportServer.configmanager!DefaultDomain!dcc!07/18/2013-17:00:48:: i INFO: Using report server external url http://APPSSERVER:80/ReportServer.configmanager!DefaultDomain!dcc!07/18/2013-17:00:48:: i INFO: Using url root http://APPSSERVER:80/ReportServer.appdomainmanager!DefaultDomain!dcc!07/18/2013-17:00:48:: i INFO: Appdomain:2 WindowsService_0 started.resourceutilities!WindowsService_0!dcc!07/18/2013-17:00:48:: i INFO: Reporting Services starting SKU: Standardlibrary!WindowsService_0!1218!07/18/2013-17:00:48:: i INFO: Catalog SQL Server Edition = Standardrshost!rshost!1390!07/18/2013-17:00:48:: i INFO: Registered url=http://+:80/ReportServer/, vdir=/ReportServer, pdir=C:\Program Files\Microsoft SQL Server\MSRS10_50.MSSQLSERVER\Reporting Services\ReportServer.rshost!rshost!1390!07/18/2013-17:00:48:: i INFO: Currently registered url http://+:80/ReportServer/ on endpoint 2crypto!WindowsService_0!1218!07/18/2013-17:00:48:: i INFO: Initializing crypto as user: NT AUTHORITY\SYSTEMrshost!rshost!1264!07/18/2013-17:00:48:: i INFO: Registered url=http://+:80/Reports/, vdir=/Reports, pdir=C:\Program Files\Microsoft SQL Server\MSRS10_50.MSSQLSERVER\Reporting Services\ReportManager.rshost!rshost!1264!07/18/2013-17:00:48:: i INFO: Currently registered url http://+:80/Reports/ on endpoint 3rshost!rshost!1264!07/18/2013-17:00:48:: i INFO: Endpoint 4 is disabled and no url is registered vdir=/ReportServer/ReportBuilder, pdir=C:\Program Files\Microsoft SQL Server\MSRS10_50.MSSQLSERVER\Reporting Services\ReportServer\ReportBuilder.resourceutilities!DefaultDomain!dcc!07/18/2013-17:00:48:: i INFO: Maximum memory limit is 65536Mbrshost!rshost!dcc!07/18/2013-17:00:48:: i INFO: Derived memory configuration based on physical memory as 8388152 KBcrypto!WindowsService_0!1218!07/18/2013-17:00:48:: i INFO: Exporting public keyservicecontroller!DefaultDomain!1264!07/18/2013-17:00:48:: i INFO: Total Physical memory: 8589467648rpcserver!DefaultDomain!1390!07/18/2013-17:00:48:: i INFO: Process monitoring started.crypto!WindowsService_0!1218!07/18/2013-17:00:48:: i INFO: Performing sku validationcrypto!WindowsService_0!1218!07/18/2013-17:00:49:: i INFO: Importing existing encryption keydbpolling!WindowsService_0!1218!07/18/2013-17:00:49:: i INFO: EventPolling polling service starteddbpolling!WindowsService_0!1014!07/18/2013-17:00:49:: i INFO: HeartbeatThread(EventPolling): heartbeat thread started.dbpolling!WindowsService_0!1218!07/18/2013-17:00:49:: i INFO: NotificationPolling polling service starteddbpolling!WindowsService_0!8ec!07/18/2013-17:00:49:: i INFO: HeartbeatThread(NotificationPolling): heartbeat thread started.dbpolling!WindowsService_0!1218!07/18/2013-17:00:49:: i INFO: SchedulePolling polling service starteddbpolling!WindowsService_0!1218!07/18/2013-17:00:49:: i INFO: UpgradePolling polling service starteddbpolling!WindowsService_0!83c!07/18/2013-17:00:49:: i INFO: PollingMaintenance: Polling startedresourceutilities!WindowsService_0!83c!07/18/2013-17:00:49:: i INFO: Maximum memory limit is 65536Mbrpcserver!DefaultDomain!1218!07/18/2013-17:00:49:: i INFO: RPC Server started.servicecontroller!DefaultDomain!1218!07/18/2013-17:00:49:: i INFO: RPC Server started. Endpoint name ='ReportingServices$MSRS10_50.MSSQLSERVER'appdomainmanager!WindowsService_0!1218!07/18/2013-17:00:49:: i INFO: Appdomain:2 WindowsService_0 initialized.appdomainmanager!DefaultDomain!128c!07/18/2013-17:01:03:: i INFO: Appdomain:3 ReportManager_MSSQLSERVER_0-1-130186044634309801 started.appdomainmanager!ReportManager_0-1!128c!07/18/2013-17:01:03:: i INFO: RS authentication mode is 5; effective ASP.NET authentication mode is Windows. vdir=/Reports.appdomainmanager!DefaultDomain!128c!07/18/2013-17:01:03:: i INFO: Appdomain:3 ReportManager_MSSQLSERVER_0-1-130186044634309801 initialized (#1).appdomainmanager!DefaultDomain!1040!07/18/2013-17:01:06:: i INFO: Appdomain:4 ReportServer_MSSQLSERVER_0-2-130186044667129637 started.appdomainmanager!ReportServer_0-2!1040!07/18/2013-17:01:07:: i INFO: RS authentication mode is 5; effective ASP.NET authentication mode is Windows. vdir=/ReportServer.appdomainmanager!DefaultDomain!1040!07/18/2013-17:01:07:: i INFO: Appdomain:4 ReportServer_MSSQLSERVER_0-2-130186044667129637 initialized (#1).webserver!ReportServer_0-2!1040!07/18/2013-17:01:13:: i INFO: Reporting Web Server startedresourceutilities!ReportServer_0-2!1040!07/18/2013-17:01:13:: i INFO: Reporting Services starting SKU: Standardresourceutilities!ReportServer_0-2!1040!07/18/2013-17:01:13:: i INFO: Maximum memory limit is 65536Mblibrary!ReportServer_0-2!d10!07/18/2013-17:01:15:: Call to GetPermissionsAction(/Demo/BrokerCENTRAL).library!ReportServer_0-2!d10!07/18/2013-17:01:15:: i INFO: Catalog SQL Server Edition = Standardcrypto!ReportServer_0-2!d10!07/18/2013-17:01:15:: i INFO: Initializing crypto as user: NT AUTHORITY\SYSTEMcrypto!ReportServer_0-2!d10!07/18/2013-17:01:15:: i INFO: Exporting public keycrypto!ReportServer_0-2!d10!07/18/2013-17:01:15:: i INFO: Performing sku validationcrypto!ReportServer_0-2!d10!07/18/2013-17:01:15:: i INFO: Importing existing encryption keylibrary!ReportServer_0-2!13d4!07/18/2013-17:01:15:: Call to GetSystemPermissionsAction().library!ReportServer_0-2!1040!07/18/2013-17:01:16:: Call to GetSystemPropertiesAction().library!ReportServer_0-2!13d4!07/18/2013-17:01:16:: Call to GetDataSourceContentsAction(/Demo/BrokerCENTRAL).library!ReportServer_0-2!1040!07/18/2013-17:01:16:: Call to GetPropertiesAction(/Demo/BrokerCENTRAL, PathBased).library!ReportServer_0-2!1040!07/18/2013-17:01:16:: Call to ListChildrenAction(/, False).library!ReportServer_0-2!13d4!07/18/2013-17:01:16:: Call to ListChildrenAction(/Demo, False).library!ReportServer_0-2!1224!07/18/2013-17:01:16:: Call to ListChildrenAction(/, False).library!ReportServer_0-2!13d4!07/18/2013-17:01:16:: Call to ListChildrenAction(/Demo, False).library!ReportServer_0-2!1224!07/18/2013-17:01:16:: Call to GetSystemPropertiesAction().library!ReportManager_0-1!f1c!07/18/2013-17:01:29:: e ERROR: Throwing Microsoft.ReportingServices.Diagnostics.Utilities.ReportServerHttpRuntimeInternalException: RsWorkerRequest::ReadEntityBody., Microsoft.ReportingServices.Diagnostics.Utilities.ReportServerHttpRuntimeInternalException: An internal or system error occurred in the HTTP Runtime object for application domain ReportManager_MSSQLSERVER_0-1-130186044634309801. ---> System.InvalidCastException: Unable to cast COM object of type 'System.__ComObject' to interface type 'Microsoft.ReportingServices.HostingInterfaces.IRsHttpPipeline'. This operation failed because the QueryInterface call on the COM component for the interface with IID '{07101601-428B-42DA-896A-7AE29CC5A777}' failed due to the following error: No such interface supported (Exception from HRESULT: 0x80004002 (E_NOINTERFACE)). at Microsoft.ReportingServices.HostingInterfaces.IRsHttpPipeline.ReadEntityBody(Byte[] buffer, Int32 offset, Int32 size) at ReportingServicesHttpRuntime.RsWorkerRequest.ReadEntityBody(Byte[] buffer, Int32 offset, Int32 size) --- End of inner exception stack trace ---;ui!ReportManager_0-1!f1c!07/18/2013-17:01:29:: e ERROR: Microsoft.ReportingServices.Diagnostics.Utilities.ReportServerHttpRuntimeInternalException: An internal or system error occurred in the HTTP Runtime object for application domain ReportManager_MSSQLSERVER_0-1-130186044634309801. ---> System.InvalidCastException: Unable to cast COM object of type 'System.__ComObject' to interface type 'Microsoft.ReportingServices.HostingInterfaces.IRsHttpPipeline'. This operation failed because the QueryInterface call on the COM component for the interface with IID '{07101601-428B-42DA-896A-7AE29CC5A777}' failed due to the following error: No such interface supported (Exception from HRESULT: 0x80004002 (E_NOINTERFACE)).library!ReportServer_0-2!1224!07/18/2013-17:01:29:: Call to GetSystemPermissionsAction().ui!ReportManager_0-1!f1c!07/18/2013-17:01:29:: e ERROR: HTTP status code --> 500-------Details--------Microsoft.ReportingServices.Diagnostics.Utilities.ReportServerHttpRuntimeInternalException: An internal or system error occurred in the HTTP Runtime object for application domain ReportManager_MSSQLSERVER_0-1-130186044634309801. ---> System.InvalidCastException: Unable to cast COM object of type 'System.__ComObject' to interface type 'Microsoft.ReportingServices.HostingInterfaces.IRsHttpPipeline'. This operation failed because the QueryInterface call on the COM component for the interface with IID '{07101601-428B-42DA-896A-7AE29CC5A777}' failed due to the following error: No such interface supported (Exception from HRESULT: 0x80004002 (E_NOINTERFACE)).library!ReportServer_0-2!1040!07/18/2013-17:01:29:: Call to GetSystemPropertiesAction().ui!ReportManager_0-1!f1c!07/18/2013-17:01:29:: e ERROR: System.Threading.ThreadAbortException: Thread was being aborted. at System.Threading.Thread.AbortInternal() at System.Threading.Thread.Abort(Object stateInfo) at System.Web.HttpResponse.End() at Microsoft.ReportingServices.UI.ReportingPage.ShowErrorPage(String errMsg)library!ReportManager_0-1!f1c!07/18/2013-17:01:33:: e ERROR: Throwing Microsoft.ReportingServices.Diagnostics.Utilities.ReportServerHttpRuntimeInternalException: RsWorkerRequest::ReadEntityBody., Microsoft.ReportingServices.Diagnostics.Utilities.ReportServerHttpRuntimeInternalException: An internal or system error occurred in the HTTP Runtime object for application domain ReportManager_MSSQLSERVER_0-1-130186044634309801. ---> System.InvalidCastException: Unable to cast COM object of type 'System.__ComObject' to interface type 'Microsoft.ReportingServices.HostingInterfaces.IRsHttpPipeline'. This operation failed because the QueryInterface call on the COM component for the interface with IID '{07101601-428B-42DA-896A-7AE29CC5A777}' failed due to the following error: No such interface supported (Exception from HRESULT: 0x80004002 (E_NOINTERFACE)). at Microsoft.ReportingServices.HostingInterfaces.IRsHttpPipeline.ReadEntityBody(Byte[] buffer, Int32 offset, Int32 size) at ReportingServicesHttpRuntime.RsWorkerRequest.ReadEntityBody(Byte[] buffer, Int32 offset, Int32 size) --- End of inner exception stack trace ---;ui!ReportManager_0-1!f1c!07/18/2013-17:01:33:: e ERROR: Microsoft.ReportingServices.Diagnostics.Utilities.ReportServerHttpRuntimeInternalException: An internal or system error occurred in the HTTP Runtime object for application domain ReportManager_MSSQLSERVER_0-1-130186044634309801. ---> System.InvalidCastException: Unable to cast COM object of type 'System.__ComObject' to interface type 'Microsoft.ReportingServices.HostingInterfaces.IRsHttpPipeline'. This operation failed because the QueryInterface call on the COM component for the interface with IID '{07101601-428B-42DA-896A-7AE29CC5A777}' failed due to the following error: No such interface supported (Exception from HRESULT: 0x80004002 (E_NOINTERFACE)).library!ReportServer_0-2!1224!07/18/2013-17:01:33:: Call to GetSystemPermissionsAction().ui!ReportManager_0-1!f1c!07/18/2013-17:01:33:: e ERROR: HTTP status code --> 500-------Details--------Microsoft.ReportingServices.Diagnostics.Utilities.ReportServerHttpRuntimeInternalException: An internal or system error occurred in the HTTP Runtime object for application domain ReportManager_MSSQLSERVER_0-1-130186044634309801. ---> System.InvalidCastException: Unable to cast COM object of type 'System.__ComObject' to interface type 'Microsoft.ReportingServices.HostingInterfaces.IRsHttpPipeline'. This operation failed because the QueryInterface call on the COM component for the interface with IID '{07101601-428B-42DA-896A-7AE29CC5A777}' failed due to the following error: No such interface supported (Exception from HRESULT: 0x80004002 (E_NOINTERFACE)).library!ReportServer_0-2!1040!07/18/2013-17:01:33:: Call to GetSystemPropertiesAction().ui!ReportManager_0-1!f1c!07/18/2013-17:01:33:: e ERROR: System.Threading.ThreadAbortException: Thread was being aborted. at System.Threading.Thread.AbortInternal() at System.Threading.Thread.Abort(Object stateInfo) at System.Web.HttpResponse.End() at Microsoft.ReportingServices.UI.ReportingPage.ShowErrorPage(String errMsg)library!ReportServer_0-2!1224!07/18/2013-17:01:36:: Call to GetPermissionsAction(/).library!ReportServer_0-2!d10!07/18/2013-17:01:36:: Call to GetPropertiesAction(/, PathBased).library!ReportServer_0-2!13d4!07/18/2013-17:01:36:: Call to GetPropertiesAction(/, PathBased).library!ReportServer_0-2!13d4!07/18/2013-17:01:36:: Call to GetSystemPermissionsAction().library!ReportServer_0-2!1224!07/18/2013-17:01:36:: Call to ListChildrenAction(/, False).library!ReportServer_0-2!13d4!07/18/2013-17:01:36:: Call to GetSystemPropertiesAction().library!ReportServer_0-2!d10!07/18/2013-17:01:36:: Call to GetSystemPropertiesAction().library!ReportServer_0-2!d10!07/18/2013-17:01:36:: Call to GetSystemPropertiesAction().