SLAS 2019: New Product Announcement

Published on 23 January 2019

In the starting blocks for SLAS 2019! Meet us BOOTH 548, we will present the evolution of PRIMO which has grown into an Automated bioengineering Platform performing both microfabrication & micropatterning!

Applications

For all the cell biology enthusiasts, this is a must-see!

Published on 21 January 2019

Giant cells moving on a building and adapting to obstacles. We are amazed by the CytoMorphoLab team’s creativity and how they used PRIMO bioengineering technology to miniaturise a building to the size of cells!

Find more details about the whole project on their website & make sure you watch THE VIDEO!

Applications

Joint Application Note with NanoSurface Biomedical

Published on 10 January 2019

Are you interested in understanding the role of the extracellular matrix in cell morphology? This application note is for you.

Check how we worked with Nanosurface Biomedical to micropattern their microstructured substrate.

Alvéole & Nature Webinar – PRIMO Bioengineering system

Published on 4 December 2018

Did you miss our live webinar presented by Dr. Manuel Théry and Dr. Harikrishnan Parameswaran? They explained how PRIMO allows to work with controlled and reproducible microenvironments in vitro to more efficiently study living cells and model diseases.

PRIMO spotted by Science Magazine

Published on 18 October 2018

A focus on “Microenvironment Mimics” explains how PRIMO allows researchers to better study living cells in vitro, by creating sophisticated and complex in vitro microenvironments to better understand and control the key parameters regulating cell functions and behavior.

New paper by researchers from Harvard University and Northeastern University using PRIMO contacltess and maskless photopatterning, show “ECM stiffness can act as a switch that regulates whether forces are transmitted via the ECM or through cell-cell contacts”.

New paper: The cytoskeleton as a smart composite material…

Published on 20 August 2018

Abstract: The interrelationship between microtubules and the actin cytoskeleton in mechanoregulation of integrin-mediated adhesions is poorly understood. Here, we show that the effects of microtubules on two major types of cell-matrix adhesions,… Read paper.

The Institute for Interdisciplinary Neuroscience, Université de Bordeaux, CNRS, in collaboration with Alvéole shows PRIMO can create complex microenvironments for cells from hydrogel structuration to precise functionalization.

New Application Note

Published on 15 May 2018

“Controlling the topography and biochemistry of cell culture substrates with PRIMO”

One of the challenges confronting cell biologists is to mimic the micro-environment in vitro to more efficiently study living cells. (…) PRIMO allows to tailor cell microenvironment topography via microfabrication and biochemistry via micropatterning…

Cell behavior study by Aurelien Roux’ Lab

When you offer cells a choice… Yes they go for the higher protein density! Experiment conducted by Pau Guillamat from Aurelien Roux’ lab – University of Geneva.

Watch the video of cells migrating towards two different protein densities in Pau Guillamat’s testimonial.

Events

Alvéole at the British Society for Developmental Biology spring meeting

Published on 16 April 2018

Meet us on Booth 8, ask us all your questions and see how PRIMO custom micropatterning system can help you tune the cell microenvironment chemistry and topography. And thus precisely control cell development and proliferation !

Users

Rockefeller University – G. M. Alushin PhD

Published on 11 April 2018

Special thanks to the team of the Laboratory of Structural Biophysics & Mechanobiology, Gregory M. Alushin PhD, The Rockefeller University, for sending us this picture of them photopatterned with PRIMO custom photopatterning system!

We look forward to seeing your experiment results with PRIMO, studying the cytoskeleton!

Applications

New paper by Virgile Viasnoff’s lab using PRIMO and micro-niches

Published on 30 March 2018

Virgile Viasnoff‘s lab at the Mechanobiology Institute –National University of Singapore is going further in controlling cell microenvironment in 3D: with micro-niches in which they control chemical, topographical and rheological cues using PRIMO photopatterning system!

PRIMO demo in Brno, Czech Republic

Published on 31 January 2018

Jakub Pospíšil – PhD student in Dr. Josef Jaros Department of Histology & Embryology at Faculty of Medicine, Masarykova univerzita – working on his first pattern with PRIMO custom micropatterning for cell control and the new version of Leonardo Photopatterning software.

Product

New version of Leonardo now available!

Published on 24 January 2018

The new version of Leonardo software is now available! Discover it on our dedicated webpage!

In addition to the replication, rotation, alignment, grayscale images management features, you can now define ROIs, program complex experimental sequences and map your samples!

Combination of micropatterning and super-resolution

PRIMO at i3S, Universidade de Porto

Published on 20 October 2017

Jorge Ferreira (Group leader) and Vanessa Nunes (PHD Student) are testing PRIMO and starting to use it on their own. Here is there first test: photopolymerization of photocurable material shaped in the i3S logo.

PRIMO at the University of Twente

Verena Schwach from Robert Passier’s lab at the University of Twente is preparing her experiments of micropatterning of cardiomyocytes on glass. We are looking forward to discovering her results.

Applications

Micrometric eclipse

Published on 21 August 2017

We witnessed a micrometric solar eclipse over France before the real one happened in the USA! Scale bar = 50µm

Applications

No limits to your patterns

Published on 16 August 2017

Pattern of the day done with PRIMO, Eiffel Tower in Fibronectin and then with MDCK cells.

Users

PRIMO now at the Northeastern University

Published on 2 August 2017

Niccole Schaible and Sam Polio from the Northeastern University – Department of Bioengineering – now have a PRIMO! They are using it to study cardiomyocytes on PDMS with direct photopatterning and cell-cell interaction on polyacrylamide gel doing micropatterning transfer.

PRIMO is at Stanford

Published on 13 July 2017

Proud to have installed a PRIMO at Stanford University! Gaspard Pardon can now start experimenting with it to micropattern proteins on hydrogels in 3D, multi-protein patterning and many other projects!

Applications

Patterning is art

Published on 12 July 2017

Thibaut Brunet shared on Twitter a picture of cells plated on micropatterns he generated with PRIMO, during the Physiology summer course at the Marine Biological Laboratory (MBL). Imaged by Nikon USA.