DiMethyl

I asked the question because I have never seen posted anywhere anything about the solubility of mdp2p in xylene, and I have looked extensively.Considering the relative chemistries of the respective molecules, it would seem reasonable that xylene would dissolve the ketone.But then chemistry is complex and I was looking for perhaps some input from someone with some actual experience with this issue.DiMethyl

Logged

indole_amine

DCM is better - it rips the crap out of every aequous solution. But Xylene is a powerful nonpolar, too - just not as miscible with water as DCM, therefore you have to do several extractions (3-5x) with more Xylene (like 3x100ml for extracting 500ml aequous soln.) and probably you'll have to fight emulsions; in contrast to DCM, where 3x65ml would probably suffice to give the same result, with easy separation (I LOVE bottom pullers! ).

indole_amine

Logged

ApprenticeCook

I was looking for perhaps some input from someone with some actual experience with this issueAnd what is that supposed to mean?man i told you the answer, DCM is better but xylene will still do the job, but you have to do more extractions, as indole has confirmed what i have said...

I cant speak for indole but as for me that IS coming from someone with exp in the field...

So, just for clarity....I have so far said:add plenty of NP and agitate, and do several extractions, pool and evap solventand then again:make sure you do several more extraction washes than normal, this will be sure to counteract any solubility differnces....

Do you need it said AGAIN?

Well here it is....DCM is better than Xylene (in this case), solubility ratio yes will be different but the main point of DCM's use is to allow easier seperation as (once again) indole has confirmed... if you cant find DCM (and god only knows why not) xylene will do but use more volume of NP and do several more washes and make sure to agitate plenty and let it settle before seperation.