What is fish odor syndrome (trimethylaminuria)?

Trimethylaminuria is a disorder in which the body is unable to break down
trimethylamine, a compound derived from the diet that has a strong odor of
rotting fish.

What are the signs and symptoms of fish odor syndrome (trimethylaminuria)?

As trimethylamine builds up in the body, it causes affected people
to give off a fish-like odor in their sweat, urine, and
breath. The intensity of
this odor may vary over time. The strong body odor can interfere with many
aspects of daily life, affecting a person's relationships, social life, and
career. Some people with trimethylaminuria experience
depression and social
isolation as a result of this condition.

What causes fish odor syndrome (trimethylaminuria)?

Although gene mutations account for most cases of trimethylaminuria, the
condition can also be caused by other factors. A fish-like body odor may result
from an excess of certain proteins in the diet or from an increase in bacteria
that normally produce trimethylamine in the digestive system. A few cases of the
disorder have been identified in adults with
liver or kidney disease. Temporary
symptoms of this condition have been reported in a small number of premature
infants and in some healthy women at the start of
menstruation.