If you are taking enteric-coated sodium valproate tablets it is important
that you don't take indigestion remedies (antacids) at the same time of day
as the tablets. This is because indigestion remedies can make the special
'enteric coating' ineffective.

Sodium valproate may increase the blood levels of the following medicines.
As this could increase the risk of their side effects, your doctor may need
to reduce the dose of these medicines if you taken them in combination with
sodium valproate:

* benzodiazepines such as lorazepam

* bupropion

* lamotrigine (sodium valproate may also increase the risk of skin reactions
associated with lamotrigine)

* phenobarbital

* phenytoin (phenytoin blood levels should be monitored if taken with sodium
valproate)

* primidone

* tricyclic antidepressants such as amitriptyline and nortriptyline

* zidovudine.

There may be increased drowsiness and sedation if sodium valproate is taken
with benzodiazepines, eg diazepam.

There may be an increased risk of side effects on the liver if sodium
valproate is taken with phenytoin or carbamazepine.

There may be an increased chance of side effects such as dizziness,
tiredness, blurred vision and vomiting if sodium valproate is taken with
carbamazepine.