-Do not know what it does, but has a one to one relationship with thrombin formation, good measure for thrombin formation

-Increased thrombin means a procoag state

-Warfarin will block prothrombin from binding factor V

10

vWF def and Hemophilia association with VIII

-Both diseases can be associated with low VIII (hemophilia is the lowest)

-vWF (made by endothelial tiss) is a carrier of VIII, when vWF is absent VIII does not last well alone in circulation, but when vWF is given to patients with def of vWF will see a rise in VIII as it is synthesized by the liver and binds to vWF

-Hemophilia with VIII def will always be low b/c VIII is acutally def

11

Actions of Heparin

-heparin can bin antithrombin III (confirmation change) and increase its affinity for thrombin