The commercial refrigeration industry is facing a one-two punch regarding major changes in regulations related to acceptable refrigerants and the allowable power consumed by an appliance. Given the know-how, the task to properly modify and test all the necessary models is overwhelming. Farrar Scientific, with our fully equipped testing facility, can access your current systems energy performance with HFCs (baseline). Then offer suggestions and modifications to reduce power consumption and move to more environmentally friendly HCs, HFOs or even a few new HFC.

With a 25 year history in the scientific / laboratory equipment industry, Farrar Scientific is very comfortable with alternative refrigerants and creative problem solving. Let us help you with your testing backlog and bottle necks.

Validation of Controlled Freezing and Thawing: A 9-L Bottle Study

Freeze–thaw processes affect the quality of biopharmaceutical proteins (1–13) and human cells (14). It has been reported that no method consistently controls freezing and thawing rates for biological formulations (1). My recent study refutes that claim with validated rate-controlled freezing and thawing of such formulations in 16-L single-use bags (15).

The study reported herein presents a consistent method for controlled-rate freezing and thawing of bottled formulations. It also highlights the effect of load and container position on freeze rates. The freeze–thaw controlled-rate chamber used in this study is a Model 4002 manufactured by Farrar Scientific. It permits rapid, uniform bulk freezing/ thawing of products with temperature ranges from 40 °C to –80 °C. The model has a minimum of 1.7 kW of net cooling and heating capacity over its entire temperature range. Units come equipped with programmable profiles that allow flexibility to meet unique product conditioning.

Validation of Controlled Freezing and Thawing Rates: A 16-L–Bag Study

It is well understood that freeze– thaw processes affect the product quality of biopharmaceuticals (1–3). It has been reported that there is no consistent method of controlled freezing and thawing rates for biological formulations (4). Traditionally, ultralow temperature storage chambers that were not designed for freezing have been used to provide an energy state for the environment surrounding the product with very little excess capacity to change the state of the product.

This study details a consistent method for controlled-rate freezing and thawing. It also includes the effect of load and container position on freeze rates. The freeze–thaw controlled-rate chamber used in this study was a model 4002 manufactured by Farrar Scientific. It permits rapid, uniform bulk freezing and/or thawing of products with temperature ranges from 40 °C to –80 °C. It has a minimum of 1.7 kW of net cooling and heating capacity over the entire temperature range and offers the flexibility of programmable profiles.