Myoepithelial cells are specialized basal epithelial cells that are found in the secretory endpieces and intercalated ducts of the normal exocrine glands, such as the salivary glands, respiratory tract glands, lacrimal glands, mammary glands, prostate glands, and sweat glands.

The intercalated ducts empty into the striated ducts, which have a single layer of cylindrical epithelium, the cells with eosinophilic cytoplasm, having a large nucleus located in the central-basal part.

In the classic definition of EMCa, the myoepithelial component consists of polygonal cells with clear cytoplasm, whereas the ductal component is composed of small lumina lined by cuboidal, mildly eosinophilic cells reminiscent of intercalated ducts.

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