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Saget was born in Philadelphia to a Jewish family. His father, Benjamin (1917–2007), was a supermarket executive, and his mother, Rosalyn (1925–2014), was a hospital administrator. Saget lived in California before moving back to Philadelphia and graduating from high school.[3][4] Saget originally intended to become a doctor, but his Honors English teacher, Elaine Zimmerman, saw his creative potential and urged him to seek a career in films.[2]

Following a short stint as a member of CBS' The Morning Program in early 1987, Saget was cast as Danny Tanner in Full House, which became a success with family viewers, and landed in the Nielsen ratings' Top 30 beginning with season three. In 1989, Saget began as the host of America's Funniest Home Videos, a role he held until 1997. During the early 1990s, Saget worked both on Full House and AFV simultaneously. In 2009, he returned to AFV for the 20th-anniversary one-hour special co-hosted with Tom Bergeron.[8]

His HBO comedy special, That Ain't Right, came out on DVD on August 28, 2007. It is dedicated to his father, Ben Saget, who died on January 30, 2007, due to complications from congestive heart failure. He was 89.

He has had recurring roles in HBO's Entourage playing a parody of himself.

In November 2013, it was announced that Saget will be touring Australia for the first time, in May 2014, with an adults-only stand-up show called Bob Saget Live: The Dirty Daddy Tour. The show will take in the major cities of Melbourne, Sydney, Brisbane and Perth.[12]

In 1998, Saget directed his first feature film Dirty Work, starring Norm Macdonald and Artie Lange. Coming off one year after he left his long-running role as host of America's Funniest Home Videos, the film received broadly negative reviews from critics, and earned low box office returns. However, it has since become a cult favorite, due partially to Artie Lange's later popularity on The Howard Stern Show where the film is sometimes mentioned, often in unflattering terms.

In 2010, Saget starred in an A&E series Strange Days in which he follows others in different activities and lifestyles, documenting their adventures in unusual ways.

In 2014, his book Dirty Daddy was released, in which Saget writes about his career, comedy influences and experiences with life and death. He embarked on a small tour in support of the book, including the Pemberton Music Festival, where he introduced Snoop Dogg prior to performing his own set.

In an interview with Ability Magazine, Saget discussed how his sister was diagnosed with scleroderma at 43, and died at 47. Before that, she had been misdiagnosed many times. "Unfortunately, rheumatologists in a lot of places don’t have very many scleroderma patients come through their labs, and no one knew what to do with her. I wish I’d known then what I know now." Because of this, Saget is involved in many fundraising benefits, towards finding a cure for the disease.[citation needed]

"There’s also a Scleroderma Foundation, and we’re separate from them, but one of the Scleroderma Foundation board heads is also on the Scleroderma Research Foundation board. We’re all basically trying to cure the same thing. Our organization has raised $25 million for research. Our chairman, Luke Evnin, is an amazing man, and lives up in San Francisco with his wife, Deann Wright. They’re both brilliant scientists and doctors. Dana Delany’s on the board, Caryn Zucker, Kristen Baker Bellamy, who lost her mother to scleroderma, and is married to Bill Bellamy. Robin Williams worked our first benefit. A number of celebrities sign on, which helps to give the disease a higher profile. As you may know, Regina, a significant number of the people who get scleroderma are African-American."[14]