アプリケーション

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション

Abreviews

特記事項

WB

1/500 - 1/5000. Predicted molecular weight: 38 kDa.

ICC

1/100 - 1/500.

ターゲット情報

関連性SIR2 is a NAD-dependent deacetylase, which participates in a wide range of cellular events including chromosome silencing, chromosome segregation, DNA recombination and the determination of life span. Involved in transcriptional repression of the silent mating-type loci HML and HMR and telomeric silencing via its association with SIR3 and SIR4. Plays a central role in ribosomal DNA (rDNA) silencing via its association with the RENT complex, preventing hyperrecombination, and repressing transcription from foreign promoters, which contributes to extending life span. Probably represses transcription via the formation of heterochromatin structure, which involves the compaction of chromatin fiber into a more condensed form, although this complex in at least one case can still bind euchromatic levels of positive transcription regulators. Although it displays some NAD-dependent histone deacetylase activity on 'Lys-9' and 'Lys-14' of histone H3 and 'Lys-16' of histone H4 in vitro, such activity is unclear in vivo and may not be essential.

細胞内局在Nuclear. Nucleolus.

別名

Conserved NAD+ dependent histone deacetylase of the Sirtuin family involved in regulation of lifespan; plays roles in silencing at HML, HMR, telomeres antibody

MAR1 antibody

NAD dependent histone deacetylase SIR2 antibody

Regulatory protein SIR2 antibody

Silent information regulator 2 antibody

Sir2p antibody

see all

Anti-SIR2 antibody (ab106169) 使用論文

ab106169
has not yet been referenced specifically in any publications.

Thank you for your email.
I am issuing you the discount codes for testing ab2977 and ab57953 in yeast. Please see below.
I have heard back regarding ab106169 and ab51024 - unfortunately, both will not cross react due to lack of sufficient seq...

Thank you for contacting us.
I have checked our catalog and have gathered the following information:
1. STE12: We don't have antibodies to this target protein in our catalog.
2. TEC1(ROC1): ab2977 has 100% homology - and qualifi...