The objective of this study is to assess the effects of oral cannabidiol (CBD; 0, 200, 400, 800 mg) on smoked marijuana's (0, 5.6% THC) subjective, reinforcing, cognitive, and cardiovascular effects. This experiment is expected to reveal CBD's intrinsic effects when combined with placebo marijuana, as well as its ability to modulate the behavioral effects of active marijuana.

Each subject in the study will be tested on eight days, each day receiving a different combination of active/inactive marijuana cigarette plus 0, 200, 400 or 800 mg of cannabidiol

Drug: cannabidiol

Other Name: cannabidiol is abbreviated CBD

Eligibility

Ages Eligible for Study:

18 Years to 50 Years

Genders Eligible for Study:

Both

Accepts Healthy Volunteers:

No

Criteria

Inclusion Criteria:

Adults between the ages of 18 and 50.

Current marijuana use: Minimum of four times per week, 0.5 joints per occasion during the preceding 4 weeks.

Able to perform study procedures

Women practicing an effective form of birth control

Exclusion Criteria:

Female subjects who are currently pregnant or breastfeeding.

Current, repeated illicit drug use other than marijuana

Presence of significant medical illness

History of heart disease

Request for drug treatment

Current parole or probation

Recent history of significant violent behavior

Major psychiatric disorder

Contacts and Locations

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study.
To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below.
For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01844687

Locations

United States, Kentucky

University of Kentucky, Straus Behavioral Research Bldg., 515 Oldham Ct.