Acid

Microdose (5–10 mcg): Users claim that a microhit of LSD clears mental locks and helps with depression. It’s often taken first thing in the morning with distilled water—chlorine can kill key compounds.Overdose: Visions, cosmic oneness, epiphanies about epiphanies.

Mushrooms

Microdose (0.1 g): A taste of psilocybin (or its synthetic version, which is often used in clinical trials) brings on a low-key wave of zenlike happiness. So they say.Overdose: Warps in spacetime.

Ibogaine Hydrochlorid

Microdose (2 mg): This drug, extracted from iboga roots, can produce a calm focus that, unlike Adderall, also acts as a mild ­aphrodisiac. (Its main use is for detox, often for opiate addicts.)Overdose: Psychedelia, vomiting, skin numbness.

DMT

Microdose (6 mg, but modes of delivery vary): The main ingredient in ayahuasca tea, DMT might change your perspective—but even small amounts could get you high.Overdose: Deep vibrations, projectile vomiting, self-transcendence.