The efficacy test of oral stimuli on salivary secretion and components

Acronym

The efficacy test of oral stimuli on salivary secretion and components

Scientific Title

The efficacy test of oral stimuli on salivary secretion and components

Scientific Title:Acronym

The efficacy test of oral stimuli on salivary secretion and components

Region

Japan

Condition

Condition

Healthy adults

Classification by specialty

Not applicable

Adult

Classification by malignancy

Others

Genomic information

NO

Objectives

Narrative objectives1

To evaluate the effects of oral stimuli on salivary secretion.

Basic objectives2

Efficacy

Basic objectives -Others

Trial characteristics_1

Trial characteristics_2

Developmental phase

Assessment

Primary outcomes

Salivary secretion and components volume

Key secondary outcomes

Salivary secretion and components rate

Base

Study type

Interventional

Study design

Basic design

Cross-over

Randomization

Non-randomized

Randomization unit

Blinding

Open -no one is blinded

Control

Placebo

Stratification

Dynamic allocation

Institution consideration

Blocking

Concealment

Intervention

No. of arms

3

Purpose of intervention

Prevention

Type of intervention

Food

Interventions/Control_1

Single ingestion of the product.
More than 24 hours washout between the ingestions.
Ingestion order: product 1, product 2, product3, product4, product5.

Interventions/Control_2

Single ingestion of the product.
More than 24 hours washout between the ingestions.
Ingestion order: product 2, product 3, product1, product5, product4.

Interventions/Control_3

Single ingestion of the product.
More than 24 hours washout between the ingestions.
Ingestion order: product 3, product 1, product2, product4, product5.

Interventions/Control_4

Interventions/Control_5

Interventions/Control_6

Interventions/Control_7

Interventions/Control_8

Interventions/Control_9

Interventions/Control_10

Eligibility

Age-lower limit

20

years-old

<=

Age-upper limit

50

years-old

>

Gender

Male

Key inclusion criteria

Healthy subjects giving written informed consent.

Key exclusion criteria

1) Subjects with a history of allergy or might be liable to allergy related to the study
2) Subjects who have serious historical disease, marked impairment, or treatment in the liver, kidney, heart, lung, gastrointestinal tract, blood, endocrine system, or metabolism system
3) Subjects with low salivary secretion.
4) Subjects deemed inappropriate to participate in this study by the principle investigator