Bullock Lab Research Opportunities

Laboratory Interests: Tumor
immunotherapy. Under the umbrella of the Human Immune Therapy
Center, our laboratory seeks to gain a greater understanding of the
interactions between the immune system and tumors. We are
particularly interested in how CD4+ “helper” T cells and dendritic
cells (which are responsible for activating T lymphocytes) contribute
to the immunological control of tumors. Our studies are intended
to help develop vaccines against tumors.

Research
Projects:

1. Analysis of the magnitude of primary, memory and recall
CD8+ T cells in response to DC pulsed with MHC class I or MHC class I
and class II-restricted peptides derived from a tumor antigen

What you will learn from this rotation:1. A general understanding of how the immune system is
being utilized to eradicate tumor cells

2. In vitro and in vivo analysis of cells associated with
immune responses. Primarily: how to generate dendritic cells; how to
perform immunizations of mice and subsequent flow cytometric analysis
of immune responses to dendritic cell immunization

3. Contemporary molecular and biochemical techniques for the
manipulation of cells involved in immune responses