Once of the things I have heard it helps with is the refractory period after an orgasm.

The product I am looking at is MUCUNA PRURIENS EXTRACT STANDARDIZED TO 15% L-DOPA 400 Mg per cap. I was thinking of 6-8 caps at bedtime.

L-Dopa (what mucuna is extracted for) will decrease PRL levels significantly- PRL and the refractory period have been linked, so it may work- I would dose regular L-Dopa at 250-500 mg, so this would be roughly in line with the 6-8 capsule dose of the 15% L-Dopa Mucuna...

Thanks for the feedback; would you notice any difference on the first dosage or when typically do u start to notice a difference?

Thought I saw somewhere that it helps to improve the appearance of your skin or something?

Originally Posted by rms80

L-Dopa (what mucuna is extracted for) will decrease PRL levels significantly- PRL and the refractory period have been linked, so it may work- I would dose regular L-Dopa at 250-500 mg, so this would be roughly in line with the 6-8 capsule dose of the 15% L-Dopa Mucuna...

L-Dopa (what mucuna is extracted for) will decrease PRL levels significantly- PRL and the refractory period have been linked, so it may work- I would dose regular L-Dopa at 250-500 mg, so this would be roughly in line with the 6-8 capsule dose of the 15% L-Dopa Mucuna...

L-Dopa (what mucuna is extracted for) will decrease PRL levels significantly- PRL and the refractory period have been linked, so it may work- I would dose regular L-Dopa at 250-500 mg, so this would be roughly in line with the 6-8 capsule dose of the 15% L-Dopa Mucuna...

Is this based on an L-Dopa study or a mucuna study though? I know you know the difference, but I don't think the general public does...or a few other companies that are not yours and which I won't name

The full spectrum bean is ideal, so getting the lower percentage MP is more suited toward sexual function. You lose some of the beautiful alkaloids if you get the bean extracted for a higher percentage of L-Dopa

Great to hear; so sounds like Mucuna Pruriens is definitely the way to go.

Originally Posted by DAdams91982

The full spectrum bean is ideal, so getting the lower percentage MP is more suited toward sexual function. You lose some of the beautiful alkaloids if you get the bean extracted for a higher percentage of L-Dopa

Having used l-dopa and mucuna pruriens extensively, i agree that mucuna is the way to go. L-DOPA gets metabolized by COMT easily. Something in the mucuna extract (15-50% extract is ideal) stabilizes the L-DOPA.

Having used l-dopa and mucuna pruriens extensively, i agree that mucuna is the way to go. L-DOPA gets metabolized by COMT easily. Something in the mucuna extract (15-50% extract is ideal) stabilizes the L-DOPA.

You've used straight L-DOPA?! The concern shouldn't be metabolism. The concern should be dyskinesias and some really serious health issues.

Is this based on an L-Dopa study or a mucuna study though? I know you know the difference, but I don't think the general public does...or a few other companies that are not yours and which I won't name

Personal experience and studies I like the mucuna extracted for L-Dopa a LOT better than synthetic L-Dopa- there is a difference from an effects standpoint, and it seems that synthetic L-Dopa transfers enzymatically quicker into dopamine and then norepi......There are studies on the difference between the two, at least from a neurotoxicity standpoint:

Department of Neurology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.

Abstract
Dopaminergic anti-parkinsonian medications, such as levodopa (LD) cause drug-induced dyskinesias (DID) in majority of patients with Parkinson's disease (PD). Mucuna pruriens, a legume extensively used in Ayurveda to treat PD, is reputed to provide anti-parkinsonian benefits without inducing DID. We compared the behavioral effects of chronic parenteral administration of a water extract of M. pruriens seed powder (MPE) alone without any additives, MPE combined with the peripheral dopa-decarboxylase inhibitor (DDCI) benserazide (MPE+BZ), LD+BZ and LD alone without BZ in the hemiparkinsonian rat model of PD. A battery of behavioral tests assessed by blinded investigators served as outcome measures in these randomized trials. In experiment 1, animals that received LD+BZ or MPE+BZ at high (6mg/kg) and medium (4mg/kg) equivalent doses demonstrated significant alleviation of parkinsonism, but, developed severe dose-dependent DID. LD+BZ at low doses (2mg/kg) did not provide significant alleviation of parkinsonism. In contrast, MPE+BZ at an equivalent low dose significantly ameliorated parkinsonism. In experiment 2, MPE without any additives (12mg/kg and 20mg/kg LD equivalent dose) alleviated parkinsonism with significantly less DID compared to LD+BZ or MPE+BZ. In experiment 3, MPE without additives administered chronically provided long-term anti-parkinsonian benefits without causing DID. In experiment 4, MPE alone provided significantly more behavioral benefit when compared to the equivalent dose of synthetic LD alone without BZ. In experiment 5, MPE alone reduced the severity of DID in animals initially primed with LD+BZ. These findings suggest that M. pruriens contains water-soluble ingredients that either have an intrinsic DDCI-like activity or mitigate the need for an add-on DDCI to ameliorate parkinsonism. These unique long-term anti-parkinsonian effects of a parenterally administered water extract of M. pruriens seed powder may provide a platform for future drug discoveries and novel treatment strategies in PD.

Abstract
BACKGROUND: The seed powder of the leguminous plant, Mucuna pruriens has long been used in traditional Ayurvedic Indian medicine for diseases including parkinsonism. We have assessed the clinical effects and levodopa (L-dopa) pharmacokinetics following two different doses of mucuna preparation and compared them with standard L-dopa/carbidopa (LD/CD).

METHODS: Eight Parkinson's disease patients with a short duration L-dopa response and on period dyskinesias completed a randomised, controlled, double blind crossover trial. Patients were challenged with single doses of 200/50 mg LD/CD, and 15 and 30 g of mucuna preparation in randomised order at weekly intervals. L-dopa pharmacokinetics were determined, and Unified Parkinson's Disease Rating Scale and tapping speed were obtained at baseline and repeatedly during the 4 h following drug ingestion. Dyskinesias were assessed using modified AIMS and Goetz scales.

RESULTS: Compared with standard LD/CD, the 30 g mucuna preparation led to a considerably faster onset of effect (34.6 v 68.5 min; p = 0.021), reflected in shorter latencies to peak L-dopa plasma concentrations. Mean on time was 21.9% (37 min) longer with 30 g mucuna than with LD/CD (p = 0.021); peak L-dopa plasma concentrations were 110% higher and the area under the plasma concentration v time curve (area under curve) was 165.3% larger (p = 0.012). No significant differences in dyskinesias or tolerability occurred.

CONCLUSIONS: The rapid onset of action and longer on time without concomitant increase in dyskinesias on mucuna seed powder formulation suggest that this natural source of L-dopa might possess advantages over conventional L-dopa preparations in the long term management of PD. Assessment of long term efficacy and tolerability in a randomised, controlled study is warranted.

Having used l-dopa and mucuna pruriens extensively, i agree that mucuna is the way to go. L-DOPA gets metabolized by COMT easily. Something in the mucuna extract (15-50% extract is ideal) stabilizes the L-DOPA.

Exactly- good post- I have used them both extensively myself as well in product development- there are substantial structural differences between 99% L-Dopa Mucuna and synthetic L-Dopa when we run them side by side via NIR- they show up extensively in the non-treated spectra, as well as the pre-treatment derivative spectra- I can show you if someone can show me how to post certain types of files as pictures........

Exactly- good post- I have used them both extensively myself as well in product development- there are substantial structural differences between 99% L-Dopa Mucuna and synthetic L-Dopa when we run them side by side via NIR- they show up extensively in the non-treated spectra, as well as the pre-treatment derivative spectra- I can show you if someone can show me how to post certain types of files as pictures........

Tried both- I am trying to transfer a .nir file from our spectrometer- I printed out a copy and scanned it, but it looks like ****- I need to find a way to darken the image slightly.....I will mess with it again today if I have time

1) Tyrosine is taken into the neuron by a sodium-dependent mechanism
2) conversion of tyrosine to L-DOPA by TH is the rate-limiting step in the biosynthetic pathway
3) L-DOPA is converted to dopamine by DDC
4) dopamine is translocated into secretory vesicles for storage, protection, and secretion
5) fusion of secretory vesicles with the plasma membrane results in dopamine release into the synaptic cleft or the extracellular space ((s is the case with the TIDA neurons)
6) dopamine binds to its membrane receptors and initiates multiple effects in target cells
7) unbound dopamine is taken up by the DAT, located in the plasma membrane of the presynaptic neuron
8) both newly synthesized dopamine and that taken up into the cell are translocated into secretory vesicles by the VMAT
9) MAO, located in the outer mitochondrial membrane, converts dopamine to a deaminated metabolite
10) COMT converts dopamine or its deaminated metabolite to biologically inactive products

Tried both- I am trying to transfer a .nir file from our spectrometer- I printed out a copy and scanned it, but it looks like ****- I need to find a way to darken the image slightly.....I will mess with it again today if I have time

The red line is synthetic L-Dopa (3 different scans); the blue lines are Mucuna Pruriens 99% L-Dopa (probably 30 different scans from a bunch of different commercial lots, plus the standard)

To interpret- the differences are very substantial in terms of the spectral footprint- especially @ 4000-5000 1/cm and 8800 1 c/m- these are the original, non-derivatized spectra- I will put up the pretreated later if you guys want- it will show the differences even more substantially....

PS it is really cool having your own in-house lab- how many other companies on this board can claim this?

I have found best results combing Lipotropin pm and activate xtreme, since they both use different percentages of L-dopa extracted from mucana, and boy the sleep is incredible not to mention the libido that one gets, for me its a surge with then a level off but everyone is different. Lipo also contains a natural decarboxylase which is EGCG from green tea, you could purchase it from the planet as well. If you really want to take your dopamine into hyperdrive, take some selegiline/rasagiline with it.

I have found best results combing Lipotropin pm and activate xtreme, since they both use different percentages of L-dopa extracted from mucana, and boy the sleep is incredible not to mention the libido that one gets, for me its a surge with then a level off but everyone is different. Lipo also contains a natural decarboxylase which is EGCG from green tea, you could purchase it from the planet as well...

Stacking Lipotrophin-PM with IGF-2 would be wicked as well - I've done this over and over and loved it!

Or you can go all three - IGF-2, Activate Xtreme, Lipotrophin-PM, and you could add to this stack Drive.

~Rosie~

Athlete ~ Trainer ~ Writer
"Think like a Champion. Train like a Warrior. Live with a Purpose." - @rosiecheewarrior

Was thinking of that, but want to keep it simple for cost and get the best effect so others have suggested America's Finest Hgh Dopa from Vitamin Shoppe or check out Dopa Mucuna 15% 400 mg, 90 Vcaps, NOW Foods.

Originally Posted by Rosie Chee Scott

Cool

Stacking Lipotrophin-PM with IGF-2 would be wicked as well - I've done this over and over and loved it!

Or you can go all three - IGF-2, Activate Xtreme, Lipotrophin-PM, and you could add to this stack Drive.