Objective: We previously showed that treatment with folic acid (FA)/B12 was associated with more rapid progression of
coronary artery disease (CAD). High doses of FA may induce methylation by increasing the availability ...

Objective—Betaine is a substrate in the betaine– homocysteine methyltransferase reaction, converting homocysteine to
methionine. There are only sparse data on plasma betaine as a determinant of the plasma total homocysteine ...

One-carbon metabolism (OCM) is linked to DNA synthesis and methylation, amino acid metabolism and cell proliferation.
OCM dysfunction has been associated with increased risk for various diseases, including cancer and ...

Established dietary predictors of plasma total homocysteine (tHcy) include folate, riboflavin, and vitamins B6 and B12, while information is scarce regarding other dietary components. The aim of this study was to examine ...

Summary The cytokine interferon gamma (IFN-&gamma;) stimulates neopterin release and tryptophan degradation into kynurenines through the kynurenine pathway. High levels of neopterin were associated with increased hip ...

Background It has been reported that interferon-&gamma; (IFN-&gamma;)&ndash;induced inflammatory markers, such as circulating neopterin and kynurenine-to-tryptophan ratio (KTR), are increased in patients with cancer and ...

Dietary intake and/or circulating concentrations of vitamin B6 have been associated with risk of cancer, but results are inconsistent and mechanisms uncertain. Pyridoxal 5'-phosphate (PLP) is the most commonly used marker ...

It is important to identify patients with Maturity-onset diabetes of the young (MODY) as a molecular diagnosis determines both treatment and prognosis. Genetic testing is currently expensive and many patients are therefore ...

Background Disturbances in one carbon metabolism may contribute to carcinogenesis by affecting methylation and synthesis of DNA. Choline and its oxidation product betaine are involved in this metabolism and can serve ...

Lower bone mineral density (BMD) in smokers may be attributable to lower body weight or fat mass, rather than to a direct effect of smoking. We analyzed the effects of smoking exposure, assessed by plasma cotinine, and ...