10 must-see movies at the 2012 Toronto Film Festival

Clive Brunskill / Getty Images

Maiken Baird's new documentary chronicles a challenging year in the lives of sisters Venus and Serena Williams, two of the world's premier tennis players, as they grapple with competition, fame, illness, injury and personal relationships.

Maiken Baird's new documentary chronicles a challenging year in the lives of sisters Venus and Serena Williams, two of the world's premier tennis players, as they grapple with competition, fame, illness, injury and personal relationships. (Clive Brunskill / Getty Images)

This ambitious adaptation of David Mitchell's multi-threaded novel boasts three directors -- Tom Tykwer ("Run Lola Run") and the Wachowski siblings, Andy and Lana ("The Matrix" trilogy) -- as well as an ensemble cast featuring Tom Hanks, Halle Berry, Hugo Weaving, Susan Sarandon and Hugh Grant. Cast members will play multiple roles throughout the film, which weaves six storylines from different eras and settings across the globe. MORE: Trailer: Cloud Atlas trailer on iTunes | 'Cloud Atlas' trailer and Lana Wachowski make debut

This ambitious adaptation of David Mitchell's multi-threaded novel boasts three directors -- Tom Tykwer ("Run Lola Run") and the Wachowski siblings, Andy and Lana ("The Matrix" trilogy) -- as well as an ensemble cast featuring Tom Hanks, Halle Berry, Hugo Weaving, Susan Sarandon and Hugh Grant. Cast members will play multiple roles throughout the film, which weaves six storylines from different eras and settings across the globe. MORE: Trailer: Cloud Atlas trailer on iTunes | 'Cloud Atlas' trailer and Lana Wachowski make debut (Warner Bros.)