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“The standard of care includes systemic administration [of antibiotics into the bone void], which is limited due to low penetration into the needed site. Local delivery may overcome this issue. However, the approved local solutions are characterized by short-term and non-controlled release of the entrapped drug,” she says.

“Currently, in the U.S., the only approved local delivery is based on a cement polymer that releases an effective amount of antibiotics over a short period (several days), which is also characterized by high burst release. This release profile is limited in the eradication of significant bacterial load, and can even lead to resistant strains of bacteria.”