The Inc. 5000 list highlights the nation's companies that have made significant gains during the past three years. The local companies represent several sectors ranging from health, real estate, software, restaurants and media.

Axe Wellness ranked highest, at No. 130. The company, which owns the Dr. Axe brand, generated revenues of $11.6 million and grew by 2,645 percent in three years, according to Inc. Created by Josh Axe, a natural medicine doctor with a background in chiropractics, the Draxe.com website features fitness, natural medicines and nutrition and has more than six million monthly visitors, according to the site. The online store sells oils and supplements, including protein shakes and probiotics.

Jones Therapy Services and Aerial Development Group also ranked in the top five growth companies for the Nashville area.

Reach Jamie McGee at 615-259-8071 and on Twitter @JamieMcGee_. Reach Holly Fletcher at 615-259-8287 and on Twitter @hollyfletcher.