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Researchers found that the lupus syndrome that developed in SWEF-deficient mice was accompanied by the accumulation of age-associated B cells that produced autoantibodies after stimulation. [Nat Immunol]
Abstract

The authors showed that immunoglobulin A immune complexes, which are present after bacterial infection of the lamina propria, are important for the induction of inflammation by the human CD103+SIRPα+ dendritic cell subset. [Nat Commun]
Full Article

Investigators showed that loss of TET2-induced PI3K activation and -increased proliferation is rescued by targeting the p110α/δ subunits of PI3K. RNA-Seq revealed a hyperactive c-Myc signature in Tet2–/– cells, which is normalized by inhibiting PI3K signaling. [JCI Insight]
Full Article

The authors review recent studies that report on the role of lipid droplets in the modulation of immune cell function, primarily focusing on myeloid cells, such as macrophages and dendritic cells. [Trends Immunol]
Abstract

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Aldeyra Therapeutics, Inc. announced that it has entered into a collaborative research agreement with Janssen Research & Development, LLC, one of the Janssen Pharmaceutical Companies of Johnson & Johnson. Aldeyra plans to collaborate with Janssen on the development of novel drugs designed to sequester pro-inflammatory aldehyde mediators, a new class of therapeutic targets. [Aldeyra Therapeutics, Inc.]
Press Release

OSE Immunotherapeutics announced that the first approvals to resume patient accrual in the global Tedopi® Phase III trial have been granted in the United States by the Institutional Review Boards. Recruitment into this trial is based on a revised protocol focused on patients with non-small cell lung cancer who have failed a previous treatment with PD-1/PD-L1 immune checkpoint inhibitors. [OSE Immunotherapeutics]
Press Release

Robert-Jan Smits, one of Europe’s most powerful figures in research, has been appointed as a special envoy on open science at the European Commission, to help push efforts to make all publicly funded research in Europe freely available by 2020. [Science|Business]
Editorial

Female scientists in India hope that more academics will report sexual harassment without fear of jeopardizing their career or reputation, after a prominent biologist was sacked for allegedly harassing a staff member. [Nature News]
Editorial

Canadian Prime Minister Justin Trudeau’s administration released its 2018 budget and scientists couldn’t be happier. It includes almost CAD 4 billion (USD 3.1 billion) in new funding for science over the next five years, a significant portion of which will go to the country’s three granting councils. [Nature News]
Editorial