Tumbling the Casket will allow you to avoid 2 stacks of poison. If you stealth tumble, it will also allow you to hit Twitch first so plan accordingly if you don't see him on the map. Twitch likes to stealth into lane to get free harass off.

I personally think Twitch is one of the best counter for Vayne, you can easy outtrade Vayne in like every stage of the Game with your E. As long as Twitch doesnt get cc'd he pretty much can't lose this lane.

Submitted By xButtHead

34

Vayne is one of the absolute squishiest ADCs in the game. Because of this, your poison passive will wreak havoc on her health, so use this to your advantage as you poke