BRILINTA WAS PROVEN EFFECTIVE BEYOND 1 YEAR AFTER A HEART ATTACK

A MAJOR CLINICAL STUDY COMPARED BRILINTA 60 MG TWICE DAILY + ASPIRIN ONCE DAILY VS ASPIRIN ALONE ONCE DAILY IN PATIENTS WHO HAD A HEART ATTACK AT LEAST 1 YEAR AGO

Patients were previously hospitalized for a heart attack 1 to 3 years before the study began

Patients were considered to be at a higher risk for another heart attack based on their age and other risk factors*

This study included over 21,000 patients

Patients were studied for up to 4 years

Patients also took other medications commonly prescribed after a heart attack.

*Patients included in the study were age 50 and over and had at least 1 additional risk factor (reduced kidney function, diabetes, disease in more than 1 blood vessel in the heart, age 65 and over, or had more than 1 prior heart attack).

BRILINTA 60 MG + ASPIRIN WAS PROVEN TO WORK BETTER THAN ASPIRIN ALONE

BRILINTA + aspirin helped protect more patients from having a heart attack or stroke or dying from a cardiovascular event than aspirin alone.

BRILINTA 60 mg + Aspirin: 487 of 7,045 patients had a heart attack or stroke or died from a cardiovascular event

Aspirin Alone: 578 of 7,067 patients had a heart attack or stroke or died from a cardiovascular event

91 FEWER PATIENTS HAD A HEART ATTACK OR STROKE OR DIED FROM A CARDIOVASCULAR EVENT WHILE TAKING BRILINTA + ASPIRIN VS ASPIRIN ALONE

SAFETY

More people treated with BRILINTA + aspirin experienced bleeding compared to those treated with aspirin alone. Of people given BRILINTA 60 mg + aspirin, 1.7% (115/6,958) experienced bleeding† that was serious or sometimes fatal, compared to 0.8% (54/6,996) of people given aspirin alone.

†Bleeding in the brain, blood loss resulting in a significant decrease in blood volume, and bleeding that resulted in death.

SELECT IMPORTANT SAFETY INFORMATION

Take BRILINTA and aspirin exactly as instructed by your doctor

You should not take a dose of aspirin higher than 100 mg daily because it can affect how well BRILINTA works

Tell your doctor if you take other medicines that contain aspirin

Do not take new medicines that contain aspirin

BRILINTA WAS STUDIED AGAINST PLAVIX IN PATIENTS WHO WERE HOSPITALIZED FOR A HEART ATTACK

IMPORTANT SAFETY INFORMATION ABOUT BRILINTA® (ticagrelor), INCLUDING BOXED WARNINGS, FOR 60-MG AND 90-MG TABLETS Read More

BRILINTA is used to lower your chance of having another heart attack or dying from a heart attack or stroke, but BRILINTA (and similar drugs) can cause bleeding that can be serious and sometimes lead to death. Instances of serious bleeding, such as internal bleeding, may require blood transfusions or surgery. While you take BRILINTA, you may bruise and bleed more easily and be more likely to have nosebleeds. Bleeding will also take longer than usual to stop.

Approved Use

BRILINTA is a prescription medicine for people who have had a heart attack or severe chest pain that happened because their heart wasn’t getting enough oxygen.

IMPORTANT SAFETY INFORMATION ABOUT BRILINTA® (ticagrelor), INCLUDING BOXED WARNINGS, FOR 60-MG AND 90-MG TABLETS

BRILINTA is used to lower your chance of having another heart attack or dying from a heart attack or stroke, but BRILINTA (and similar drugs) can cause bleeding that can be serious and sometimes lead to death. Instances of serious bleeding, such as internal bleeding, may require blood transfusions or surgery. While you take BRILINTA, you may bruise and bleed more easily and be more likely to have nosebleeds. Bleeding will also take longer than usual to stop.

Call your doctor right away if you have any signs or symptoms of bleeding while taking BRILINTA, including: severe, uncontrollable bleeding; pink, red, or brown urine; vomit that is bloody or looks like coffee grounds; red or black stool; or if you cough up blood or blood clots.

Do not stop taking BRILINTA without talking to the doctor who prescribes it for you. People who are treated with a stent, and stop taking BRILINTA too soon, have a higher risk of getting a blood clot in the stent, having a heart attack, or dying. If you stop BRILINTA because of bleeding, or for other reasons, your risk of a heart attack or stroke may increase. Tell all your doctors and dentists that you are taking BRILINTA. To decrease your risk of bleeding, your doctor may instruct you to stop taking BRILINTA 5 days before you have surgery. Your doctor should tell you when to start taking BRILINTA again, as soon as possible after surgery.

Take BRILINTA and aspirin exactly as instructed by your doctor. You should not take a dose of aspirin higher than 100 mg daily because it can affect how well BRILINTA works. Tell your doctor if you take other medicines that contain aspirin. Do not take new medicines that contain aspirin.

Do not take BRILINTA if you have a history of bleeding in the brain, are bleeding now, or are allergic to ticagrelor or any of the ingredients in BRILINTA.

Slow heart rhythm has been reported with BRILINTA.

BRILINTA can cause serious side effects, including bleeding and shortness of breath. Call your doctor if you have new or unexpected shortness of breath or any side effect that bothers you or that does not go away. Your doctor can decide what treatment is needed.

Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. BRILINTA may affect the way other medicines work, and other medicines may affect how BRILINTA works. Tell your doctor if you are breastfeeding or plan to breastfeed. You should not breastfeed while being treated with BRILINTA.

APPROVED USE

BRILINTA is a prescription medicine for people who have had a heart attack or severe chest pain that happened because their heart wasn’t getting enough oxygen.

BRILINTA is used with aspirin to lower your chance of having another serious problem with your heart or blood vessels such as heart attack, stroke, or blood clots in your stent if you received one. These can be fatal.

The information on this Web site should not take the place of talking with your doctor or health care professional. If you have any questions about your condition, or if you would like more information about BRILINTA, talk to your doctor or pharmacist. Only you and your health care professional can decide if BRILINTA is right for you.