The largest margin of defeat for a #1 team in the Sweet Sixteen is #13 Florida over #1 Duke 87-78 in 2000.

The largest margin of defeat for a #1 team in the Round of 32 is UCLA over #1 DePaul 77-71 in 1980. That game is also the largest margin of defeat for an unranked team over a #1 team.

Between 2006 and 2009, the #1 team was defeated by 8 or more points each year. Only one other time in tournament history had there even been consecutive years in which the #1 team lost by 8 or more points (1959 and 1960).