The domain within your query sequence starts at position 1144 and ends at position 1188; the E-value for the EGF_Lam domain shown below is 6.64e-11.

EGF_Lam

Laminins [(PUBMED:2404817)] are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation. They are composed of distinct but related alpha, beta and gamma chains. The three chains form a cross-shaped molecule that consist of a long arm and three short globular arms. The long arm consist of a coiled coil structure contributed by all three chains and cross-linked by interchain disulphide bonds. Beside different types of globular domains each subunit contains, in its first half, consecutive repeats of about 60 amino acids in length that include eight conserved cysteines [(PUBMED:2666164)]. The tertiary structure [(PUBMED:8648630), (PUBMED:8648631)] of this domain is remotely similar in its N-terminal to that of the EGF-like module. It is known as a 'LE' or 'laminin-type EGF-like' domain. The number of copies of the LE domain in the different forms of laminins is highly variable; from 3 up to 22 copies have been found. A schematic representation of the topology of the four disulphide bonds in the LE domain is shown below.

In mouse laminin gamma-1 chain, the seventh LE domain has been shown to be the only one that binds with a high affinity to nidogen [(PUBMED:7781764)]. The binding-sites are located on the surface within the loops C1-C3 and C5-C6 [(PUBMED:8648630), (PUBMED:8648631)]. Long consecutive arrays of LE domains in laminins form rod-like elements of limited flexibility [(PUBMED:2404817)], which determine the spacing in the formation of laminin networks of basement membranes [(PUBMED:8349613)].

This information is based on mapping of SMART genomic protein database to KEGG orthologous groups. Percentage points are related to the number of proteins with EGF_Lam domain which could be assigned to a KEGG orthologous group, and not all proteins containing EGF_Lam domain. Please note that proteins can be included in multiple pathways, ie. the numbers above will not always add up to 100%.