Transcript for Go Behind the Scenes With Neil Patrick Harris on Broadway

Test Text1 italics Test Text1 pl yeah. Good-bye Barney Simpson. Hello fish nets. Harris is starring on Broadway in the revival of "Hedwig a the angry inch." I've embraced the glitter. It's everywhere. How is this guy doing? He's kind of unbelievable. It's kind of unreal. It's true. He's stunning. You're blushing. &#9834; I put on my makeup turn on the 8-track &#9834; Reporter: The punk rock musical was a critically acclaimed movie and offbroadway show over a decade show, telling the story of a transgender woman from east Berlin after a botched sex change. Now, the original creative team is back. I've never heard the song sound this good. Reporter: Steven Trapp composed the song and knew Harris would be perfect. I liked the sound of his voice. And I heard him talk and sing. I knew all along. Reporter: John Cameron Mitchell wrote the book and starred as the original Hedwig. You were Hedwig. I was Hedwig. And I'll tell you there is something more relaxing than watching him do it. Thank god I don't have to do it. Reporter: And lea hall plays Hedwig's significant other. He is the greatest drag queen of all-time. Reporter: I was looking at you in the first few haven'ts of the show and asking, man or woman? I have no idea. Thank you. A lot of people who come to see the show, they can't find me until I start singing. Reporter: To make the transformation, takes Neil Patrick Harris two hours a night. This is the pink room. I got to choose the colors. I wanted this room to be super kinetic. Reporter: Harris' transformation is more than just makeup and miniskirts. I lost 20 pounds for the role, to be more feminine, which changed my whole posture. I'm becoming like Jared Leto anorexic. Every time I eat a sandwich, just one chip. I eat the chip. Oh, what have I done? Are you love wearing the wigs? And how hot is it? They're very hot. Thank you for bringing that up. Oh, other hot. They're warm, yeah. Reporter: I found that out for myself, when co-star Lena hall took me backstage to the all-important wig room. Oh, no. Really? A girl can dream. Reporter: For all of the laughs, there is a serious and poignant message at the show's center. When you peel back this onion that is Hedwig and you get past the wigs and the outfits, it's a story that can apply to all of us. It's about misfits and losers. For me, it's fun to play Hedwig and start the show with a lot of people quizzically staring at me and think it's for shock value. And by the end, feel they're united with her. That's a really fun journey to get to take. A journey, indeed. I cannot say enough about this show. Neil Patrick Harris will be with us tomorrow, live, on "Good morning America," to talk all about it. Congratulations to you. It was tremendous.

This transcript has been automatically generated and may not be 100% accurate.

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