Disease: Shigellosis and enterotoxigenic Escherichia coli (ETEC)

Published in Epidemiology and Infection, this article examines both population- and facility-based studies of ETEC infections and identifies a need for additional large, population-based studies combined with facility-based studies …

Published in Epidemiology and Infection, this article seeks to identify contemporary gaps in the understanding of the global epidemiology of shigellosis, through a review of the English-language scientific literature from 1984 to 2005, …

This article, published in Vaccine, outlines current candidates for a safe and effective vaccine against ETEC. The authors argue that a critical roadblock to achieving this goal has not been the science as much as the lack of a sufficiently funded …

This review article, published in Vaccine, describes the approaches to enterotoxigenic Escherichia coli (ETEC) and Shigella vaccines that are currently under development, including a range of both cellular and subunit approaches for each pathogen. …

This article, published in the New England Journal of Medicine, provides a description of bacterial diarrhea and evidence supporting various strategies to combat this problem. Also included are a list of pathogens that cause bacterial diarrhea and …

This article, published in The Lancet, reports on results of the Global Enteric Multicenter Study (GEMS), which was designed to identify the aetiology and population-based burden of pediatric diarrheal disease in sub-Saharan Africa and south Asia. …

This market assessment aims to increase the awareness of biotechnology and pharmaceutical companies worldwide about the opportunities and potential markets that exist for low-cost and effective vaccines against enterotoxigenic Escherichia coli …

COTS is an e-book, funded by the US Agency for International Development, designed to export the clinical, scientific, and public health expertise on cholera and shigellosis from the International Centre for Diarrhoeal Disease Research, …

This article, published in Vaccine, describes the results of a randomized, comparator controlled, double-blind Phase 1 trial in 60 Swedish adults testing a prototype of a new oral vaccine candidate against enterotoxigenic Escherichia coli (ETEC) …

This article, published in Clinical and Vaccine Immunology, describes the results of a Phase 1 trial of a trivalent, live attenuated enterotoxigenic Escherichia coli vaccine candidate, ACE527. The study indicated that ACE527 had a strong safety …

Published in Health Policy and Planning, this compares cost-of-illness (COI) with stated preference estimates of willingness-to-pay associated with shigellosis in a rural area of China to evaluate the economic benefits of disease …

This article, published in PLoS Neglected Tropical Diseases, reports on a study that aimed to identify protective antigens shared by many enterotoxigenic Escherichia coli (ETEC) strains to help inform the development of new vaccine candidates. Using …

This article, published in Value in Health, discusses a study to develop a cost function model to estimate the public treatment cost of shigellosis patients in Thailand. The study was an incidence-based cost-of-illness …

This article, published in Vaccine, describes the development and preclinical testing of new oral vaccine against enterotoxigenic Escherichia coli (ETEC) administered alone and in combination with an adjuvant. The studies found that oral …

A fast-dissolving tablet (FDT) that could be packaged in a compact stackable blister sheet is a potentially attractive option for formulating oral vaccines, since it would minimally impact the cold chain and could potentially be administered …

This presentation from the Vaccines for Enteric Diseases conference provides results from a clinical trial that found the human challenge model currently being used to test vaccines against enterotoxigenic Escherichia coli (ETEC) is utilizing a …

Diarrheal Disease: Solutions to Defeat a Global Killer presents scientific evidence to support strategies to scale up use of interventions, including safe water, improved sanitation and hygiene, breastfeeding and optimal complementary feeding, …

This joint report from the World Health Organization and the United Nations Children's Fund (UNICEF) focuses attention on the prevention and management of diarrheal diseases. It examines the latest available information on the burden of childhood …

Published in Infection and Immunity, a cohort of 321 children were followed from birth up to two years to determine the incidence of enterotoxigenic Escherichia coli (ETEC) in Bangladesh. Children with ETEC diarrhea were underweight and stunted …

Published in the journal Vaccine, this article discusses the importance of creating reliable, long-term demand for the next generation of enteric vaccines, including new rotavirus, Shigella, and ETEC vaccines and priorities for achieving this …

Enteric infections, with or without overt diarrhea, have profound effects on intestinal absorption, nutrition, and childhood development as well as on global mortality. Oral rehydration therapy has reduced the number of deaths from dehydration …

From the Weekly Epidemiological Record, this report is from an international consultative meeting on ETEC to examine the most recent epidemiological data from the field, identify gaps in the laboratory methods for strain …

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