Figure 2.

Confidence scores assigned to the C. jejuni protein interactions. (a) The distribution of confidence scores generated for the CampyYTH v3.1 protein interactions
are shown in red. The distributions of scores for the training sets containing likely
true positives (green) or true negatives (black) are also shown. (b) Protein interaction pairs with high confidence scores (HCS; confidence scores > 0.5)
share the same functions significantly more frequently (p value < 3 × 10-57) than protein pairs comprising interactions with low confidence scores (LCS; confidence
scores ≤ 0.5). Protein 'self' interactions were excluded from the analysis. (c) The average depth of shared GO biological process annotation was determined for the
interactions comprising each confidence score bin. Higher confidence interactions
generally involve proteins with the same functional annotation at greater depths of
precision. The two dotted line segments are linearly fitted lines between average
GO depth and bin number in two regions, from 0.5 to 0.9 and 0.9 to 1.0. Protein 'self'
interactions were excluded from the analysis.