This species is the most commercially important of the mahoganies. The level of exploitation has led to the exhaustion of supplies particularly in the northern parts of its range. Regeneration of the species is stochastic, depending in nature on large-scale disturbance. This ecological strategy makes mahogany vulnerable to logging regimes. Harvesting and processing are generally only 50 percent efficient. There is, at present, little economic incentive to manage natural stands sustainably.

International trade in timber of the species is subject to the provisions of Appendix II of CITES. The Appendix II listing covers the Neotropical populations (including logs, sawn wood, veneer sheets and plywood) and entered into effect on 15 November 2003. Export quotas have been granted to certain countries.