Has a cheap and effective treatment for chronic pain been lying under clinicians' noses for decades? Researchers have found that a very high dose of an opiate drug that uses the same painkilling pathways as morphine can reset the nerve signals associated with continuous pain - at least in rats.

If confirmed in humans, the procedure could reduce or eliminate the months or years that millions of patients spend on pain-managing prescription drugs. The results of the study are described today in Science1.

In a new book, neuroscientists Sam Wang and Sandra Aamodt detail how parents can help their children learn the ABCs and self-control. The book, Welcome to Your Child's Brain, explores how the human brain develops from infancy to adolescence.

When a cycad is ready to reproduce, it grows a large colorful cone, rich with pollen or seed. It signals its readiness by radiating heat or sending out attractive odors to pollinators, who travel back and forth. Once fertilized, the seed-rich cone is ripped apart by hungry seed carriers (who've included over the years, not just birds and insects, but dinosaurs, pterosaurs, bats; these trees have been eaten by just about everybody). But what if you can't find a mate? The tree in London (and its clones that are now growing in botanical gardens all over the world) is a male. It can make pollen. But it can't make the seeds. That requires a female. Researchers have wandered the Ngoya forest and other woods of Africa, looking for an E. woodii that could pair with the one in London. They haven't found a single other specimen. They're still searching. Unless a female exists somewhere, E. woodii will never mate with one of its own. It can be cloned. It can have the occasional fling with a closely related species. Hybrid cycads are sold at plant stores, but those plants aren't the real deal. The tree that sits in London can't produce a true offspring. It sits there, the last in its long line, waiting for a companion that may no longer exist.

Music, an abstract stimulus, can arouse feelings of euphoria and craving, similar to tangible rewards that involve the striatal dopaminergic system. Using the neurochemical specificity of [11C]raclopride positron emission tomography scanning, combined with psychophysiological measures of autonomic nervous system activity, we found endogenous dopamine release in the striatum at peak emotional arousal during music listening. To examine the time course of dopamine release, we used functional magnetic resonance imaging with the same stimuli and listeners, and found a functional dissociation: the caudate was more involved during the anticipation and the nucleus accumbens was more involved during the experience of peak emotional responses to music. These results indicate that intense pleasure in response to music can lead to dopamine release in the striatal system. Notably, the anticipation of an abstract reward can result in dopamine release in an anatomical pathway distinct from that associated with the peak pleasure itself. Our results help to explain why music is of such high value across all human societies.

For teenagers, friends play a big role in the decision to take that first drink. And by the 12th grade, more than 65 percent of teens have at least experimented with alcohol. But what parents do during the high school years can also influence whether teens go on to binge drink or abuse alcohol. Researchers at Brigham Young University have found that teenagers who grow up with parents who are either too strict or too indulgent tend to binge drink more than their peers.

For some adults, there is a tendency to go beyond the call of duty. Particularly, when they are faced with choosing to allow or not allow. Maybe the scientific explanation is to do or not to do. And the reaction isn't always the most appropriate but it is better to be safe than sorry. What is the scientific explanation for adults that don't react or react inappropriately even when it's involves saving a teenager? What is the scientific solution for those in the center of difficult situations, who are not strict or liberal? What does a mind do when it is present many times in a teenage situation and it is not the parent?

A new study in The Lancet rates the harmfulness of 20 psychoactive drugs according to 16 criteria and finds that alcohol comes out on top. Although that conclusion is generating headlines, it is not at all surprising, since alcohol is, by several important measures (including acute toxicity, impairment of driving ability, and the long-term health effects of heavy use), the most dangerous widely used intoxicant, and its abuse is also associated with violence, family breakdown, and social estrangement. A group of British drug experts gathered by the Independent Scientific Committee on Drugs (ISCD) rated alcohol higher than most or all of the other drugs for health damage, mortality, impairment of mental functioning, accidental injury, economic cost, loss of relationships, and negative impact on community. Over all, alcohol rated 72 points on a 100-point scale, compared to 55 for heroin, 54 for crack cocaine, and 33 for methamphetamine. Cannabis got a middling score of 20, while MDMA (Ecstasy), LSD, and psilocybin mushrooms were at the low end, with ratings of 9, 7, and 6, respectively.