Adrenalectomy was performed at 8 weeks and mice were studied at 10 weeks. Mice were bled in the morning in the nonfasted state. Food intake was measured in individually housed mice 7–11 days after adrenalectomy. Data are means ± SE; n = 6 per group.

*

*P < 0.05 vs. sham group of the same genotype;

†

†P < 0.05 vs. wild-type sham.

TABLE 2

Metabolic parameters during basal (12-h fasted) period and hyperinsulinemic-euglycemic clamp in the sham-operated and adrenalectomized wild-type and A-ZIP/F-1 female mice.