Abstract : The PL480 project has completed its second year and rhesus monkey models for radical curative and causal prophylactic testing have been validated. Construction of a large multistory primate colony building has been completed. The activities of 13 WRAIR and CDRI compounds were evaluated in the rhesus monkey model with five compounds found to be more active than the primaquine controls. Radical curative properties of 11 compounds (5 WRAIR and 6 CDRI) were evaluated with 5 compounds found to be more active than primaquine controls.