About Caralluma Fimbriata

Caralluma fimbriata is an edible cactus that grows in Africa, the Middle East, Asia, and India. It has been traditionally used for centuries by Indigenous hunters to support appetite control and improve stamina.* All evidence suggests that a healthy lifestyle which includes reduced calorie intake and increased physical activity levels is our best weapon for losing fat and keeping it off. Caralluma fimbriata may play a role in facilitating this process. The studies that have been conducted utilizing an extract from this cactus show promise.*

How Does Caralluma Fimbriata Work?

Understanding The Appetite Control Mechanisms

A region of the brain known as the Hypothalamus and at its base, the Pituitary gland is central to the appetite control mechanism. It has been established that appetite is modulated by several different hormonal pathways that control either orexigenic (appetite stimulation) or anorexogenic (appetite control).*

The chart below shows some of the different polypeptides (neuropeptides) produced by the body and indentified by researchers that influence the regulation of appetite.

Orexigenic Neuroopeptides (Appetite Stimulating)

Agouti-related protein (AgRP)

Ghrelin

Neuropeptide Y (NPY)

Fibroblast Growth Factor19 (FGF19)

Orexigenic Neuroopeptides (Appetite Stimulating)

Leptin (produced in fat cells)

Cholecystokinin (CCK)

Incretins

Peptide YY

A review of the scientific literature reveals that the genus Caralluma contains many glycosidic (flavones glycosides, flavones, magastigmane glycosides) compounds. In Caralluma Extract (CE) researchers have identified a particular form - pregnane glycosides as one of the major constituents. In studies from other plant species, Pregnane glycosides appear to modulate food intake (suppress appetite) by decreasing the activity of one or more of the orexigenic neuropeptides (See the chart above).*

About Irvingia Garbonensis

Irvingia gabonensis (African Mango) is a tree that grows in the Eastern Central African states. An extract of the fruit seed has been and is currently being studied for its benefits in supporting leptin sensitivity (one of the anorexigenic neuropeptides) , and weight loss management.

How Does Irvingia Garnoensis Work?

Irvingia gabonensis (African Mango) is high in soluble fiber which is an accepted lipid-lowering supplement in conjunction with a normal diet and moderate exercise in overweight individuals. It is also suggested to help slow the rate of carbohydrate absorption.* Fat cells (adipocytes) secrete a hormone called leptin that tells our brain (in the hypothalamus) we have eaten enough. Leptin can also facilitate the breakdown of stored triglycerides in our adipocytes (fat cells) via the process of lipolysis (the breakdown of fats). Heavy individuals have startlingly high blood levels of leptin, indicating that their cells have become resistant to the leptin that is supposed to prevent them from putting on so many fat pounds. African Mango has demonstrated beneficial effects upon leptin blood levels, followed by weight loss and inches off the waistline.*

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