During the past couple of years I continued my investigations into taming autoimmune disease and addressing the mechanisms that underlie it (and will always continue to do so). I found some approaches that looked promising and began experimenting with them with my patients, as well as recruiting other practitioners I know to work with the same principles. I came across a few discoveries that have produced profound results. One is the concept of glutathione recycling.

Glutathione and stress

In the thyroid book I introduced glutathione, our bodys most powerful antioxidant, and how integral it is to modulating the immune system. Ideally the body makes sufficient glutathione to help keep everything running smoothly, however it becomes depleted in the face of extreme or chronic stress.

Modern life bombards us with stressors, the most common being ongoing insulin surges from sugary, high-carb diets, immune aggravation from food intolerances, chronic gut infections (too much bad bacteria or parasites), hormonal imbalances, lack of sleep, and of course our hectic, information-overloaded lifestyles.

Many people suffer from all of the above on a daily basis and also may smoke, drink too much, or even overtrain athletically, compounding an already precarious situation. Of course autoimmune disease itself is a significant stressor, further depleting the bodys precious supply of glutathione.

In fact, I might go so far as to say it is difficult for the body to produce an autoimmune attack if the glutathione system is functioning properly.

Boosting glutathione levels though a liposomal cream or intravenouslyas glutathione taken orally is ineffectiveis a key strategy in combating the damage of stress. However these levels can be quickly depleted if the body cannot recycle glutathione to keep the supply on hand to meet the many stressors.

Glutathiones job is to take the bullet

Before I can explain how glutathione recycling works, I first need to explain more about how specifically glutathione protects us. Glutathione is like the bodyguard or Secret Service agent whose loyalty is so deep that she will jump in front of a bullet to save the life of the one she protects. When there is enough of the proper form of glutathione in the body to take the bullet, no inflammatory response occurs. However when glutathione becomes depleted it triggers a destructive inflammatory process.

Glutathione recycling explained

Glutathione recycling is a separate function from just boosting glutathione levels through a liposomal cream, intravenously, a nebulizer, a suppository, or other means. These forms of glutathione delivery will help ones antioxidant status but they do not raise levels of glutathione inside the cells. Glutathione is the main antioxidant for mitochondria, the little factories inside each cell that convert nutrients into energy. Some cells have more mitochondria than others depending on the cells function. This is important because an autoimmune disease destroys the mitochondria in the affected cells, thus causing tissue destruction, and glutathione protects these mitochondria.

Reduced glutathione versus oxidized glutathione

But not just any form of glutathione does thisit needs to be reduced glutathione. There are two main forms of glutathione in the body: reduced glutathione (GSH) and oxidized glutathione (GSSG).

Reduced glutathione, or GSH, is the bodyguard who takes the hit from free radicals that damage cells. Free radicals are molecules that are unstable because they have unpaired electrons and are looking for another electron to steal in order to become stable. They steal electrons from the mitochondria, thus destroying them and causing inflammation and degeneration.

However when theres plenty of GSH in the cell, the GSH sacrifice themselves to the free radicalsthrowing themselves in front of the bulletin order to protect the mitochondria. Thus the GSH ends up with an unpaired electron and becomes unstable, at which point it becomes GSSG, or oxidized glutathione, which is technically a free radical itself.

Doesnt this make GSSG dangerous to the cell then? When there is sufficient glutathione in the cell, the unstable GSSG naturally pairs with available glutathione in the cell with the help of an enzyme called glutathione reductase, returning back to its reduced glutathione state so its ready for action once again.

The key thing to remember is that two enzymes play important roles in these processes:

Glutathione peroxidase triggers the reaction of GSH to GSSG, which is when glutathione takes the hit to spare the cell

Glutathione reductase triggers the conversion of GSSG back to useable GSH.

These enzymes come into consideration when we look at how to support the glutathione system nutritionally.

The link between poor glutathione recycling and autoimmune disease

Studies show a direct correlation between a breakdown in the glutathione system and autoimmune disease. The ability to constantly take oxidized glutathione and recycle it back to reduced glutathione is critical for managing autoimmunity.

Fortunately studies also show various botanicals, nutritional compounds, and their cofactors have been shown to activate glutathione reductase and the synthesis of reduced glutathione. By boosting this enzyme and supplementing glutathione levels we can increase glutathione levels and glutathione recycling to quench inflammation once it starts, or, even better, to prevent inflammation in the first place.

Studies have also shown that efficient glutathione recycling helps boost the TH-3 system, the branch of the immune system that helps balance the TH-1 and TH-2 systems and prevent autoimmune reactivity. (I explain TH-1 and TH-2 systems of immunity in my book.) Proper glutathione activity not only helps protect cells, research shows it also modulates cell proliferation and immunity, and helps tissues recover from damage.

Glutathione recycling helps repair leaky gut

Good glutathione recycling helps tame autoimmune diseases in another way. One thing I have found universal in all my autoimmune patients is poor gut integrity. They all suffer from some degree of leaky gut and repairing the gut is vital to the recovery process. Studies show glutathione may play an important role in gut barrier function and the prevention of intestinal inflammation.

A compromised glutathione recycling system can worsen intestinal destructionthe person with multiple food sensitivities and a gut that never heals may be victim of this mechanism. Although repairing a leaky gut is vital to taming an autoimmune response, we can see now glutathione recycling is another vital piece to the puzzle of restoring gut health.

Supporting glutathione recycling

So how do we support glutathione recycling? The first thing is to reduce the stressors depleting this vital system. The bulk of my thyroid book is devoted to this: balancing blood sugar, addressing food intolerances, restoring gut health, and managing adrenal function are foundational.

Other considerations are neurotransmitter imbalances and hormonal imbalances, which may require specialized guidance from a qualified health care practitioner. And of course making any lifestyle changes you can, such as getting enough sleep, paring down an overactive schedule, making exercise a priority each day, creating time to do things you love, and so on.

Once you have addressed these factors (which for many people can actually take care of the problem) and autoimmune dysfunction persists, then boosting glutathione recycling may be necessary. Below I cover the basic botanicals and nutritional compounds researchers have found support glutathione recycling pathways.

N-acetyl-cysteine (NAC): NAC is a key compound to glutathione activity. It is rapidly metabolized into intracellular glutathione.

Alpha-lipoic acid (ALA): ALA directly recycles and extends the metabolic life spans of vitamin C, glutathione, and coenzyme Q10, and it indirectly renews vitamin E, all of which are necessary for glutathione recycling.

L-glutamine: Research has shown that l-glutamine is important for the generation of glutathione. It is transported into the cell, converted to glutamate, and readily available to intracellular glutathione synthesis.

Selenium: Selenium is a trace element nutrient that serves as the essential cofactor for the enzyme glutathione peroxidase, which converts GSH to GSSG so glutathione can take the hit by free radicals to spare cells.

Cordyceps: Cordyceps has been shown to activate both glutathione and peroxidase synthesis in the body. It has also been shown to protect cells by engaging the glutathione enzyme cycle.

Gotu kola (Centella Asiatica): Research has clearly demonstrated that oral intake of gotu kola rapidly and dramatically increases the activity and amount of glutathione peroxidase and the quantity of glutathione.

Taken together these botanicals and compounds activate the glutathione peroxidase and reductase enzymes that promote a healthy glutathione recycling system.

For people with severe leaky gut issues I suggest they take these compounds as they work on repairing leaky gut. Also, its important to use these in conjunction with a liposomal glutathione cream discussed in the book. These compounds work more on recycling glutathione than boosting overall levels. This way the glutathione you do take, whether through a cream, an IV, a nasal spray, or other method is assured to stay in your body longer and get inside your cells where they can do their best work.

Glutathione recycling is imperative to taming autoimmune disease

Promoting glutathione recycling helps protect cell mitochondria, enhance tissue recovery, modulate an imbalance between TH-1 and TH-2, and boost immune regulation. The overall effect is to dampen both the autoimmune reaction and damage to body tissue. It also helps body tissue and the intestinal tract regenerate and recover. Keeping overall glutathione levels up by supporting glutathione recycling helps buffer the bodys cells from the many stressors hurled at us each day.

Other practitioners and I have witnessed patients rebuild their glutathione recycling system. As a result they are much less or no longer sensitive to chemicals around them, they have fewer autoimmune flare-ups, and they recover much faster from their flare-ups.

This seems to tie together all the keywords I'm interested in: autoimmune disease, glutathione depletion, leaky gut and above all reduction of symptoms. Unfortunately in my condition I can't follow such a long post. Would love to hear richvank's take on this.

It's nice to see someone else beating the drum for glutathione! I haven't been aware of the involvement of glutathione depletion in autoimmune diseases, except that I suspect it in the case of Hashimoto's autoimmune thyroiditis, which occurs with high prevalence in ME/CFS cases.

I think it is a good idea to support the B-complex vitamins, too, in connection with recycling glutathione, since glutathione reductase needs B2 and B3, and B1 supports the pentose phosphate shunt that makes the NADPH from B3 that is needed by glutathione reductase.

Thanks, very useful and interesting. I've had difficulty sorting out the various glutathione products. I looked at the liposomals and creams, but haven't had read too many experiences or recommendations. I've even looked at making my own liposomal. Anyone have any recommendations or experiences to impart for the various specific products?