Canola meal was used to replace fishmeal protein in diets for fry of tilapia (Oreochromis niloticus L. 1758) at rates of 0 (control), 10%, 20%, 30%, 40%, and 50%. The diets contained approximately 30% crude protein and 3000 kcal/kg digestible energy. The fry were fed 90 days and the growth, feed conversion ratio, protein efficiency ratio, hepatosomatic index, reno- somatic index, and body composition were determined. The final weight (5.12 g) and feed intake (7.99 g) of fry fed the 10% diet did not significantly differ from those of the control. Weight gains declined beyond this replace- ment level, probably because of increased levels of antinutritional factors, particularly glucosinolates. Whole body percentages for moisture, crude lipid, crude protein, and ash were unaffected by the dietary treatment. Re- sults indicate that protein from canola meal can replace up to 10% of protein from fishmeal in diets for tilapia fry.