Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

Applications

Approved:

IHC - Paraffin

ICC

Western blot

Immunoprecipitation

(applications tested for the base form of this product only)

Specificity and Use

Immunogen:

AGER / RAGE antibody was raised against synthetic peptide corresponding to a sequence mapping at the N-terminal of human advanced glycosylation end-product-specific receptor(RAGE), identical to the related rat and mouse sequence.

Epitope:

N-Terminus

Specificity:

Human, mouse, rat. No cross reactivity with other proteins.

Usage:

The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested.

Packaging

Presentation:

50% slurry in PBS, pH 7.2, 0.01 mg sodium azide

Storage:

Store at 4°C

Restrictions:

For research use only.

About AGER / RAGE

Description: Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes.