Abstract

Sulfadiazine (2-sulfanilamido-pyrimidine) and sodium sulfadiazine are following sulfathiazole and sodium sulfathiazole in experimental and clinical trial just as these thiazole derivatives followed sulfapyridine and its sodium salt. Already a number of reports1-10 on the absorption, excretion, acetylation, diffusion, toxicity, and therapeutic effects of sulfadiazine in man have appeared, but because the indication is strong that sulfadiazine and its sodium salt will displace largely the other sulfonamide drugs, additional observations on the pharmacology of this drug seem important.

Previous reports on the pharmacology of sulfadiazine have dealt primarily with the observations made following a single dose of the drug and in