This article is an overview of the life and times of Professor Mary-Anne Plaatjies Van Huffel, an ordained minister in the Uniting Reformed Church in Southern Africa. She is currently professor in Systematic Theology and Church Polity at the University of Stellenbosch, and co-minister of URCSA in Scottsdene, Kraaifontein in the Western Cape. She is the current moderator of the General Synod of URCSA, and the vice-president of the World Council of Churches. This article is an appraisal of a remarkable church leader and theologian in recent times. This appraisal focuses on her pioneering work in URCSA, the Faculty of Theology at Stellenbosch University, and her work as a feminist theologian in South Africa, the African continent and the ecumenical world at large. The significance of Professor Plaatjies Van Huffel is not only rooted in her leadership positions, the many theological publications, or her lecturing status, but can be found in her active participation in processes to transform society. The information in this article is based on interviews, published articles, books and media sources.