Along with Ron Darling, one of Yale University's most prominent players to come to the majors is Wild Bill Hutchison, who won 42 games in 1890 for the Chicago National League team, and 44 games the next year for them. Both performances led the league in wins.

President George H. W. Bush, although not a major league player, was captain of the Yale team in 1948. There is a photo taken that year of Bush, Smoky Joe Wood, and Babe Ruth, who visited New Haven one day.