TY - JOUR
A1 - Scheller, Bertram
A1 - Castellano, Marta
A1 - Vicente, Raul
A1 - Pipa, Gordon
T1 - Spike train auto-structure impacts post-synaptic firing and timing-based plasticity
T2 - Frontiers in computational neuroscience
N2 - Cortical neurons are typically driven by several thousand synapses. The precise spatiotemporal pattern formed by these inputs can modulate the response of a post-synaptic cell. In this work, we explore how the temporal structure of pre-synaptic inhibitory and excitatory inputs impact the post-synaptic firing of a conductance-based integrate and fire neuron. Both the excitatory and inhibitory input was modeled by renewal gamma processes with varying shape factors for modeling regular and temporally random Poisson activity. We demonstrate that the temporal structure of mutually independent inputs affects the post-synaptic firing, while the strength of the effect depends on the firing rates of both the excitatory and inhibitory inputs. In a second step, we explore the effect of temporal structure of mutually independent inputs on a simple version of Hebbian learning, i.e., hard bound spike-timing-dependent plasticity. We explore both the equilibrium weight distribution and the speed of the transient weight dynamics for different mutually independent gamma processes. We find that both the equilibrium distribution of the synaptic weights and the speed of synaptic changes are modulated by the temporal structure of the input. Finally, we highlight that the sensitivity of both the post-synaptic firing as well as the spike-timing-dependent plasticity on the auto-structure of the input of a neuron could be used to modulate the learning rate of synaptic modification.
KW - spike train
KW - auto-structure
KW - STDP
KW - temporal correlations
KW - integrate and fire
KW - non-Poissonian
Y1 - 2011
UR - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/24857
UR - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:hebis:30:3-248573
SN - 1662-5188
VL - 5
IS - 60
SP - 1
EP - 16
PB - Frontiers Research Foundation
CY - Lausanne
ER -