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.Net Framework Implications

Hi,

I have created a VB/C++ .Net app that needs to run on a set of computers
that have a standard operating environment (namely NT4.0 service pack 6a).

I will need to install the framework onto these computers for my app to run.
The problem is, I need to know all the implications the framework will have
on the SOE (Standard Operating Environment). Things like, does the Framework
sit on top of the O/S or does it integrate with it? Does it make any changes
to the os or any related programs - eg. word or excel?

If anyone knows the answers to these questions, that would be great. However,
it would also be good if someone could point me to a site (preferably somewhere
in Microsoft) that has all this sort of information.