1Center for Magnetic Resonance and Optical Imaging, University of Pennsylvania, Philadelphia, PA, United States, 2Research Branch, Sidra Medical and Research Center, Doha, Qatar

Metabolic regulation is disrupted in many diseases. As a result, the
levels of lactate present in the body are often affected and implicated in
disease progression and clinical outcome. To better understand lactate
metabolism, an imaging technique with high sensitivity and
spatial resolution is required. In this study, a chemical exchange saturation
transfer (CEST) magnetic resonance imaging method, based on the exchange
between lactate hydroxyl proton and bulk water protons was used to image
lactate. As proof-of-principle, LATEST was implemented in vivo in exercising
human skeletal muscle to image the increased lactate that results from intense
exercise.

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