What is EIB?

EIB (exercise-induced bronchospasm).

EIB stands for exercise-induced bronchospasm. It is sometimes called exercise-induced asthma.
People who experience EIB find it hard to breathe during or after exercise.

Why? This is because when we exercise, cool, dry air moves quickly in and out of our lungs,
causing the loss of heat, water or both from the respiratory tree. This causes a temporary
tightening of the airways, which can lead to:

Coughing

Wheezing

Shortness of breath

Chest tightness

These types of symptoms usually occur 5–15 minutes after beginning physical activity.

If this happens to you, you’re not alone. As many as one in 10 people in America experience
EIB, many of whom do not have asthma. That’s an estimated 30-plus million adults and
children, including some of the world’s best athletes. In fact, an eight-time Olympic
short-track speed skating medalist competed despite his EIB-related breathing
problems.

Also, many people have EIB but don’t even realize it. One study found that as many as 29%
of athletes had EIB that was “unrecognized.” So it’s important to be aware of these types
of symptoms.

EIB may make you feel frustrated. But the good news is that there are things you can do.
For example, using ProAir RespiClick® 15–30 minutes before exercising can
help prevent EIB. Ask your doctor if ProAir RespiClick® may be right for
you.

Because EIB breathing issues are “short-term,” you need to treat them only before sports
or exercise.

How does EIB affect you?

EIB can cause temporary coughing, wheezing and chest tightness during or after exercise.
Many people who experience EIB may avoid exercising and other physical activity because
they’re afraid it’ll trigger their exercise-related breathing problems. However, a lack
of physical exercise can lead to other problems, like obesity or diabetes.

But there’s no reason why EIB should keep you from staying active.

How does ProAir RespiClick® help you breathe during exercise?

When you take ProAir RespiClick® before exercise:

1.The muscles in your airways stay relaxed.

2.More air is able to flow through your airways.

3.You can breathe more freely.

The active ingredient in ProAir RespiClick® is a medicine called
albuterol, which is inhaled directly into the lungs.
Once there, it works quickly to relax the muscles in the airways, allowing more air to
pass through.

Tips to train by.

Most people with EIB don’t need to limit their physical activity, unless instructed to do
so by their healthcare provider. Using ProAir RespiClick® (albuterol sulfate)
Inhalation Powder 15–30 minutes before exercising can help prevent or reduce the effects of
EIB for two to three hours in most people.

Here are some additional steps you can take to prevent the breathing problems associated
with EIB:

Warm up before you start exercising

Cool down after you exercise

Exercise indoors when pollen counts are high

Exercise indoors when the air outside is cold and dry, because it can trigger EIB. If
you do exercise in these conditions, wear a scarf around your mouth.

Consider getting a flu shot and don’t exercise if you are sick

Keep track of your allergies, and take steps to avoid exposure to things that cause
allergy symptoms (allergens)

Make sure that your coaches and trainers are aware that you have asthma or get EIB and
know where you keep your ProAir RespiClick® rescue inhaler, so that they know what to
do if you start to have symptoms or have an attack

If you don’t already have ProAir RespiClick®, learn more about it
here so you can talk to your doctor about a “rescue rethink” instead
of just a rescue refill.

APPROVED USES

ProAir RespiClick® (albuterol sulfate) Inhalation Powder is indicated in
patients 4 years of age and older for the treatment or prevention of bronchospasm with
reversible obstructive airway disease and for the prevention of exercise-induced
bronchospasm.

IMPORTANT SAFETY INFORMATION

Do not use ProAir RespiClick® (albuterol sulfate) Inhalation Powder if you are allergic
to albuterol sulfate, lactose, or milk proteins. Call your doctor right away if you
develop red, itchy bumps on your skin, swelling beneath your skin or in your throat,
rash or worsening trouble breathing

If your symptoms become significantly worse when you use ProAir RespiClick®, seek
medical attention immediately. This may indicate either a worsening of your asthma or a reaction
to the medication. Either of these could be life-threatening

Do not increase your dose or take extra doses of ProAir
RespiClick® without first talking to your healthcare professional

Before using ProAir RespiClick®, be sure to tell your healthcare professional if
you have a heart, blood, thyroid or seizure disorder, high blood pressure, diabetes, are pregnant
or planning to become pregnant, or are breastfeeding or planning to breastfeed

ProAir RespiClick® can cause significant heart-related side effects, such as an
increase in pulse, blood pressure and/or related symptoms. If you have a heart condition, your
healthcare professional will determine if ProAir RespiClick® is right for you

Make sure your healthcare professional knows all the medicines you are taking — especially
other inhaled medicines, other asthma medicines, heart and blood pressure medicines and drugs
that treat depression — because some medicines may interfere with how well your asthma medicines
work

Common side effects in patients 12 years of age and older taking ProAir RespiClick®
include back pain, body aches and pains, upset stomach, sinus headache, and urinary tract
infection

Common side effects in patients 4 to 11 years of age taking ProAir RespiClick®
include upper respiratory infections, mouth and throat pain, and vomiting

Tell your healthcare provider if you have any side effect that bothers you or that does not go
away

These are not all of the possible side effects of ProAir RespiClick®. For more
information, ask your healthcare provider or pharmacist

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit
www.fda.gov/medwatch, or call
1-800-FDA-1088

ProAir RespiClick® is a registered trademark of Teva Respiratory, LLC.

PRS-41003 April 2018

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APPROVED USES

ProAir RespiClick® (albuterol sulfate) Inhalation Powder is indicated in
patients 4 years of age and older for the treatment or prevention of bronchospasm with
reversible obstructive airway disease and for the prevention of exercise-induced
bronchospasm.

IMPORTANT SAFETY INFORMATION

Do not use ProAir RespiClick® (albuterol sulfate) Inhalation Powder if you are allergic
to albuterol sulfate, lactose, or milk proteins. Call your doctor right away if you
develop red, itchy bumps on your skin, swelling beneath your skin or in your throat,
rash or worsening trouble breathing

If your symptoms become significantly worse when you use ProAir RespiClick®, seek
medical attention immediately. This may indicate either a worsening of your asthma or a reaction
to the medication. Either of these could be life-threatening

Do not increase your dose or take extra doses of ProAir
RespiClick® without first talking to your healthcare professional

Before using ProAir RespiClick®, be sure to tell your healthcare professional if
you have a heart, blood, thyroid or seizure disorder, high blood pressure, diabetes, are pregnant
or planning to become pregnant, or are breastfeeding or planning to breastfeed

ProAir RespiClick® can cause significant heart-related side effects, such as an
increase in pulse, blood pressure and/or related symptoms. If you have a heart condition, your
healthcare professional will determine if ProAir RespiClick® is right for you

Make sure your healthcare professional knows all the medicines you are taking — especially
other inhaled medicines, other asthma medicines, heart and blood pressure medicines and drugs
that treat depression — because some medicines may interfere with how well your asthma medicines
work

Common side effects in patients 12 years of age and older taking ProAir RespiClick®
include back pain, body aches and pains, upset stomach, sinus headache, and urinary tract
infection

Common side effects in patients 4 to 11 years of age taking ProAir RespiClick®
include upper respiratory infections, mouth and throat pain, and vomiting

Tell your healthcare provider if you have any side effect that bothers you or that does not go
away

These are not all of the possible side effects of ProAir RespiClick®. For more
information, ask your healthcare provider or pharmacist

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit
www.fda.gov/medwatch, or call
1-800-FDA-1088