Research Description:Dr. Lawrence Lamb is a Clinical Laboratory Immunologist and Professor of Medicine specializing in transplantation immunology. He also is cross-appointed as Professor of Pathology and Pediatrics and is boarded by the Oncology Nursing Certification Corporation for Advanced Practice in Oncology Nursing (AOCNS). Dr. Lamb directs the UAB Cell Therapy Laboratory and cGMP Cell Manufacturing Facility in the Section of Bone Marrow Transplant and Cellular Therapy. Dr. Lamb's group was the first to describe homeostatic reconstitution of gamma/delta T cells in patients who receive alpha/beta T cell depleted bone marrow grafts and an association between gamma/delta T cell recovery with disease-free survival in allogeneic bone marrow transplantation patients as well as gamma/delta T cell receptor CDR3 conservation in leukemia patients. He currently directs an independent research program for evaluation and translation of innate cell-based therapies for Glioblastoma Multiforme and has been funded by the NINDS (5R21NS57341), NCI (2 P50 CA097247), Elsa Pardee Foundation, Leukemia and Lymphoma Society. He also held the National Brain Tumor Society's Samuel Gershon Leadership Chair for Glioblastoma Research for 2008-2010. Dr. Lamb's laboratory anticipates the initial clinical trials for this therapy to initiate in late 2013.