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The message you are getting is presumably on the source system which is an iSeries.

Please review the target event log as there is probably an error there which has caused the refresh to fail, killed the target processes and prevented the iSeries from maintaining communication with the target.

The most likely cause is a duplicate key error on the target. CDC does not check for unique access paths for an iSeries source; if you do not have a unique access path defined in the physical file or the related logical files, the best practice is to use relative record number as a substitute key on the target, populated by journal control column &CNTRRN. Please note that when RRN replication is enabled, if the source file member is reorganised, CDC will have to refresh the table to ensure that the target remains in synch with the source,