Two Bronx neighbors were returning from the Dominican Republic when the feds caught the women by the seat of their pants — quite literally.

Priscilla Pena and Michelle Blassingale had just arrived at JFK aboard a JetBlue airliner from Santo Domingo when they were stopped by Customs and Border Protection officers.

A drug-sniffing dog alerted officers when it neared Pena, but the feds searched her luggage without finding any drugs, officials said.

Then the officers initiated a pat-down of the two women and discovered that each was wearing what authorities called a “diaper” filled with cocaine and rigged like a girdle around their hind quarters, officials said.

Together, the women were charged with smuggling approximately 6 1/2 kilos of cocaine.

Blassingale was held in custody by a Brooklyn federal judge, while Pena was released on $150,000 bond, records show.