Jefferson, who signed a three-year, $41 million contract this offseason, didn't participate in the morning shootaround and was seen walking around before the game with a noticeable limp.

Jefferson missed most of training camp after turning his ankle when he landed on Chris Bosh's foot during the team's second preseason game against Miami. Jefferson played in the regular-season opener at Houston on Wednesday night and had 13 points and eight rebounds in a loss.

Clifford says Bismack Biyombo will start at center.

Clifford says he doesn't believe Jefferson hurried back too soon, saying "there's no way to gauge that type of injury."