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This report documents the results of sediment incubations and other studies undertaken to assist in the evaluation of nitrate addition and oxygenation as required in the Record of Decision (ROD) for the Onondaga Lake Bottom Subsite (NYSDEC and USEPA 2005) and the Statement of Work appended to the Consent Decree between Honeywell and the New York State Department of Environmental Conservation (NYSDEC) for remediating the lake bottom. This work is applicable to the deep water portion of Sediment Management Unit 8 (SMU 8) where water depths exceed 9 meters (30 feet). The objectives of the work were to establish the efficacy of oxygen and nitrate addition in blocking methylmercury production, the quantities of nitrate and oxygen required to meet sediment demand, and the interplay between conditions in the water column and sediment dynamics.