Anti-CAMK1 Antibody

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General Information

Product name

Anti-CAMK1 Antibody

Short Description

Rabbit polyclonal to CAMK1

Description

Calcium/calmodulin-dependent protein kinase I is expressed in many tissues and is a component of a calmodulin-dependent protein kinase cascade. Calcium/calmodulin directly activates calcium/calmodulin-dependent protein kinase I by binding to the enzyme and indirectly promotes the phosphorylation and synergistic activation of the enzyme by calcium/calmodulin-dependent protein kinase I kinase.

Product Properties

Target

Gene ID

Gene Symbol

Molecular Weight

41.3 kDa

Database Links

Alternative Names

CAMK1Calcium/calmodulin-dependent protein kinase type 1 CAMK1

Function

Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, regulates transcription activators activity, cell cycle, hormone production, cell differentiation, actin filament organization and neurite outgrowth, Recognizes the substrate consensus sequence [MVLIF]-x-R-x(2)-[ST]-x(3)-[MVLIF], Regulates axonal extension and growth cone motility in hippocampal and cerebellar nerve cells, Upon NMDA receptor-mediated Ca(2+) elevation, promotes dendritic growth in hippocampal neurons and is essential in synapses for full long-term potentiation (LTP) and ERK2-dependent translational activation, Downstream of NMDA receptors, promotes the formation of spines and synapses in hippocampal neurons by phosphorylating ARHGEF7/BETAPIX on 'Ser-694', which results in the enhancement of ARHGEF7 activity and activation of RAC1, Promotes neuronal differentiation and neurite outgrowth by activation and phosphorylation of MARK2 on 'Ser-91', 'Ser-92', 'Ser-93' and 'Ser-294', Promotes nuclear export of HDAC5 and binding to 14-3-3 by phosphorylation of 'Ser-259' and 'Ser-498' in the regulation of muscle cell differentiation, Regulates NUMB-mediated endocytosis by phosphorylation of NUMB on 'Ser-276' and 'Ser-295', Involved in the regulation of basal and estrogen-stimulated migration of medulloblastoma cells through ARHGEF7/BETAPIX phosphorylation (By similarity), Is required for proper activation of cyclin-D1/CDK4 complex during G1 progression in diploid fibroblasts, Plays a role in K(+) and ANG2-mediated regulation of the aldosterone synthase (CYP11B2) to produce aldosterone in the adrenal cortex, Phosphorylates EIF4G3/eIF4GII, In vitro phosphorylates CREB1, ATF1, CFTR, MYL9 and SYN1/synapsin I.

Cellular Localization

Cytoplasm

Tissue Specificity

Widely expressed, expressed in cells of the zona glomerulosa of the adrenal cortex.