With increasing concern about health care–associated infections and transmission of multidrug-resistant organisms (MDROs), there has been substantial support for universal decolonization strategies, especially for high-risk patients, such as those in the intensive care unit (ICU). One such strategy that is being adopted widely is the use of daily chlorhexidine bathing. However, the findings of Noto and colleagues1 in this issue of JAMA challenge this approach.