Carlisle, 37, who has previously spoken of his mental health issues, spent six weeks in a psychiatric unit after he was hit by a lorry in 2014.

Lancashire Police said they were “extremely concerned” about him.

A spokeswoman said he was last seen by a family member in Preston’s Flag Market at about 14:30 BST on Thursday.

The father of-three, who has tattoos on his arm, was wearing a black jacket, a black T-shirt, blue jeans and Nike trainers.

Carlisle, who remarried earlier this year, played for teams including Burnley, Queens Park Rangers and Leeds United and was also chairman of the Professional Footballers’ Association.

He has spoken previously about attempting to take his own life in his 20s and also when he was hit by a lorry near York shortly before Christmas in 2014.

In 2015, he launched a mental health charity called the Clarke Carlisle Foundation for Dual Diagnosis – a condition that has been described as “mental health problems co-occurring with drug or alcohol misuse”.