The are several types of chaperons, some can bind just short part of polypeptide (e.g. after translation or during transport through membrane) or they can bind whole protein inside (as GroEL-GroES system)

@andrewsome of them do, like the GroEL-GroES complex. But there are other kind of chaperones. Proteins like Kar2 and Hrd3 seem to be able to bind any exposed hydrophobic segments, but they are nowhere near as elaborate as Gro

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