RT Journal
A1 Kuehn BM
T1 SErotonin syndrome update
JF JAMA
JO JAMA
YR 2011
FD December 28
VO 306
IS 24
SP 2661
OP 2661
DO 10.1001/jama.2011.1868
UL http://dx.doi.org/10.1001/jama.2011.1868
AB
The FDA had warned in July that linezolid (an antibiotic) or methylene blue (a drug used to treat methemoglobinemia that is also used as a marker or dye in some diagnostic procedures) can interact with drugs affecting the serotonin system. Since then, the agency learned that SSRIs and SNRIs are the psychiatric drugs most likely to trigger serotonin syndrome. The agency said it is not yet clear whether other psychiatric medications with weaker effects on the serotonin system are as likely to trigger these adverse events when used with linezolid or methylene blue.