Role of hippocampal p11 in the sustained antidepressant effect of ketamine in the chronic …

Role of hippocampal p11 in the sustained antidepressant effect of ketamine in the chronic …

Citation: Translational Psychiatry (2016) 6, e741; doi:10.1038/tp.2016.21Published online 23 February 2016H-L Sun1,3, Z-Q Zhou1,3, G-F Zhang1, C Yang2, X-M Wang1, J-C Shen1, K Hashimoto2 and J-J Yang1 Top of page Introduction Depression is one of the most common psychiatric disorders affecting nearly 20% of the population worldwide, and more than half of the suicides are accompanied by depression.1, 2, 3, 4, 5 Antidepressants such as selective serotonin reuptake inhibitors (5-hydroxytryptamine, 5-HT) and noradrenaline reuptake inhibitors are the clinically prescribed drugs for the treatment of depression. However, it takes several weeks for these drugs to exert the antidepressant effects; moreover their remission rates are only approximately 40%.4, 6 Therefore, more studies are urgently needed to find a new, effective approach and to examine the pathophysiology of depression. A number of studies have shown that a single subanesthetic dose of ketamine, a…