Help with GUI layout creation

I am new to this (mostly programmed console apps) and totally lacking design skills. I understand about horizontal, and vertical and grid layout, yet I feel uncapable of solving a simple design, for my task.

This is the look of my window I would like to create:

I have no clue how to pull it together?
What should I use for this? Vertical or horizontal layout? More layers?

For starters, I would say 2 vertical layouts on top of 3 horizontal layouts?