rl/rl ne-reelin

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Myc-tagged <i>reelin</i> under the control of the rat <i>nestin</i> intermediate-filament gene promoter was introduced into fertilized one-cell FvB mouse embryos by microinjection. <i>Ne-reelin</i> mice (strain FvB) were bred to <i>reeler</i> mice (strain B6C3Fe) from the Jackson Laboratory to generate mice that were transgenic for <i>ne-reelin</i> and mutant for <i>reelin</i>.
Mice carrying <i>ne-reelin</i> express an additional source of reelin mRNA throughout the ventricular zone of the forebrain, midbrain, and cerebellum at E16.5.