Purpose. To determine the extent to which the MOR and PMR correctly identify true underlying associations between certain occupations/industries and mortality from specific cancers and what the important determinants are that contribute towards...

The endomorphins are peptides isolated from the brain with high affinity and selectivity for the mu opioid receptor (MOR) (Nature 386:499, 1997). At least two paradigms illustrate differences in the effects of endomorphin-1 (Tyr-Pro-Trp-Phe) (EM1)...

Opioids acting at the mu (morphine) receptor represent the vast majority of clinically used opioids and remain the most effective analgesics for treating moderate to severe pain. The use of morphine and similar compounds for the management of pain...

The endomorphins are endogenous opioids with high affinity and selectivity for the mu opioid receptor (MOR). Endomorphin-1 (Tyr-Pro-Trp-Phe-NH2 ,EM1) and endomorphin-2 (Tyr-Pro-Phe-Phe-NH2, EM2) have been localized to many regions of the central...

Previous studies from this laboratory have shown that acute administration of morphine induces translocation of protein kinase C (PKC) betaII in a subset of neurons in rat brain (Garcia and Harlan 1995). As these neurons do not express mu opioid...

The endomorphins are endogenous peptides; that have high affinity and selectivity for the mu opiate receptor and potent analgesic activity. The distributions of endomorphin 1 (Tyr-Pro-Trp-Phe-NH2, EM1) and endomorphin 2 (Tyr-Pro-Phe-Phe-NH2, EM2)...

Endogenous ligands for the mu-opioid receptor (MOR) have been implicated in the central control of minute ventilation (VE) (Shook, et al. 1990). While these studies examined the effects of beta-endorphin on V E, beta-endorphin binds to the mu- and...