The adoption center at the Macy's store is open 9 a.m. to 9 p.m. most days, she said.

The SPCA brings some animals over from the shelter in the morning and about six to 12 animals are on display at any given time. The pets are rotated through the windows depending on how well they get along with one another, Maloney said.

Last year, about 300 animals showcased in the windows were adopted and more than $70,000 in donations were raised for the San Francisco SPCA.

"We're hoping to do even better this year," Maloney said.

Elementary-aged students from San Francisco's De Marillac Academy will be present at the window unveiling at 5 p.m. today.

De Marillac Academy is a private school in the Tenderloin that offers tuition-free education to children from low-income households.