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Newly Identified Gene May Link to Autism and Other Neuro Disorders

Researchers at The Children's Hospital of Philadelphia (CHOP) say they identified a gene that looks like it plays a significant role in raising a person's risk of having more severe subtypes of autism that co-occur with other genetic diseases, such as the chromosomal disorder 22q11.2 deletion syndrome. Variations in this gene, RANBP1, may disrupt brain signaling in different neuropsychiatric conditions, a finding that could open new research opportunities for treatment for multiple neurological diseases, according to the scientists.Article by: Genetic Engineering and Biotechnology News; January 20, 2016

Scientists Say Juvenile Rheumatoid Arthritis and Other Autoimmune Conditions Could Be Inherited

The results from this study enable us to better understand the genetic component of these diseases and how they are genetically related to each other, thereby explaining why different autoimmune disorders often run in the same family.Article by: ScienceLine; Novermber 13, 2015

Researchers Estimate Heritability of Childhood Autoimmune Diseases

A Children's Hospital of Philadelphia-led team of researchers has quantified the heritability of nine pediatric-onset autoimmune diseases. CHOP's Hakon Hakonarson and his team examined genotyping data from more than 5,000 unrelated pediatric autoimmune disease patients and 36,000 controls and found that type 1 diabetes and juvenile idiopathic arthritis had the highest levels of heritability, as they reported today in Nature Communications.Article by: GenomeWeb; October 09, 2015

CHOP wins $3.6 million NIH grant for study on patient care decisions

Researchers will analyze DNA sequencing in common pediatric conditions and evaluate how sharing this information with patients impacts treatment decisions.Article by: Philly Voice; September 19, 2015

Genetic Overlapping in Multiple Autoimmune Diseases May Suggest Common Therapies

CHOP Recognizes Outstanding Young Researchers

CHOP Research’s Distinguished Research Trainee Awards provide institution-wide recognition for exceptional CHOP Research trainees. The 2015 Awards sees two young researchers from the Center for Applied Genomics each claim the prestigious award. Article by: Cornerstone (CHOP); June 05, 2015

Missing genetic link found in a challenging immune disease

In the largest genetic study to date of a challenging immunodeficiency disorder, CAG scientists have identified a gene that may be a "missing link" between overactive and underactive immune activity. The gene candidate also plays a key role in autoimmune diseases such as type 1 diabetes, rheumatoid arthritis and allergies.Article by: Medical XPress; April 22, 2015

Babies’ BMI May Predict Childhood Obesity

A new study from The Children’s Hospital of Philadelphia shows body mass index (BMI) during infancy may help to predict if a child will be obese by age four.Article by: CHOP Cornerstone; March 24, 2015

Study of Rare Disease Reveals Gene Crucial to Immune Defense

Genomics researchers from the Center for Applied Genomics (CAG) at The Children’s Hospital of Philadelphia investigating a serious, rare disease called common variable immunodeficiency (CVID) have discovered a gene linked to immune defense.Article by: CHOP Cornerstone; March 13, 2015

More Genetic Clues Found in a Severe Food Allergy

Scientists in Philadelphia have identified four new genes associated with the severe food allergy eosinophilic esophagitis (EoE). Because the genes appear to have roles in other allergic diseases and in inflammation, the findings may point toward potential new treatments for EoE.Article by: Science Codex; November 21, 2014