Welcome

IMPACT: International Mission for Prognosis and Analysis of Clinical
Trials in TBI.

Traumatic Brain Injury (TBI) may afflict us all, but young adult males are
particularly at risk. IMPACT is an international multidisciplinary effort
to advance clinical research programmes in search of better treatment.

Nearly 10 years of work has resulted in the development of a prognostic
calculator for establishing prognosis in individual patients, proposals
for standardization of data collection in TBI studies (common data elements)
and recommendations for improving the design and analysis of TBI studies.
It is hoped that these recommendations will substantially increase
possibilities for proving efficacy of new treatments. We greatly
welcome any feedback you may have

Background

Traumatic Brain Injury (TBI) is a dynamic and heterogeneous disease in
which many mechanisms and pathways can lead to secondary damage. Many
different kinds of therapy and neuroprotective agents with high
potential for efficacy have been developed.

Unfortunately in trials none of these have shown convincing evidence
of benefit in the clinical situation with sufficient generalizibility.
Some of these therapies may have been truly ineffective but the risk
exists that some therapies may have been wrongly discarded due to the
use of insensitive methodology in clinical trials.

The TBI population poses several complicated methodological challenges,
related to the heterogeneity of the population, outcome-assessment and
design issues. IMPACT is focused on tackling these head-on with the aim
of providing recommendations for more powerful trials in the future.

The IMPACT Project is focused on advancing knowledge of prognosis, trial-design
and treatment in TBI.

IMPACT has

developed and validated prognostic models for classification and characterization
of TBI series

participated in the development of standardization of data collection in TBI studies
(common data elements).

provided evidence based recommendations for improving sensitivity and efficiency
of trials in TBI

IMPACT will

continue its research efforts towards provision of further evidence in support of
efforts to improve treatment.

Advise and assist in the development of clinical research programmes, investigating
new treatments for TBI which could lead to better patients outcomes.

A silent epidemic

A deadly killer

A field in medicine with one of the highest unmet needs

Can strike us all

Changes lives forever

Most important IMPACT recommen-dations for TBI trials

Calculate the prediction models for 6 month outcome after TBI with the help of our
online prognostic calculator.

Common Data Elements summarize proposals for selection and coding of variables for TBI studies. Currently,
this is a draft/beta version. Feedback or comments are very welcome and will be highly appreciated.