RESULTS: fBAT analysis showed no association between COMT alleles/haplotypes and ADHD diagnosis and EF parameters. Using ANCOVA in the Caucasian only sample, significant associations between COMT haplotypes, and WCST indices were observed. However, after correction for multipletesting, the only significant effect observed was between rs6269 and the number of categories completed (a measure of concept formation ability) on the WCST, F(1,285) = 8.92, p = .003.

CONCLUSION: These results tentatively implicate COMT gene in modulating EF in children with ADHD.