5 year old boy with jaw swelling, hematuria and abdominal swelling with bilateral renal masses and a 1 year old girl with a 4 month history of gradual abdominal swelling followed by gross hematuria (J Egypt Natl Canc Inst 2015;27:97)

Downregulated vascular endothelial growth factor A (VEGFA) and its interacting genes may initiate clear cell sarcoma of the kidney (CCSK) development by interrupting two different pathways, kinase regulation and protein tyrosine kinase metabolism

IIn a 2016 gene expression study of 14 CCSK and 3 fetal kidney samples, a total of 2681 differentially expressed genes were identified, of which 2138 genes were downregulated, including VEGFA, and 543 were overexpressed (Oncol Lett 2016;11:953)

In a pure stromal type WT treated with preoperative chemotherapy, the stroma may show a striking clear cell sarcoma-like appearance, and extensive sampling may be required to find foci with other WT components (Popov: Wilms Tumor, 2016)

This website is intended for pathologists and laboratory personnel, who understand that medical information is imperfect and must be interpreted using reasonable medical judgment. Click here for patient related inquiries.