Cholesterol synthesis is controlled significantly by the hepatic HMG Co A reductase. Hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase produces mevalonate, an important intermediate in the synthesis of cholesterol and essential nonsterol isoprenoids. The reductase is subject to a range of forms of feedback control through various mechanisms mediated by sterol and nonsterol end-products of mevalonate…