Methods: In this experimental study, 220 adult male NMRI mice were anesthetized and then placed in a stereotaxic apparatus. Two stainless-steel cannuale were placed in the CA1 region of hippocampus. The elevated plus maze test has been used to test anxiety-like behaviors. Two and one-way analyses of variance (ANOVAs) followed by LSD test, were used for analysis of the data. All experiments were performed in accordance with institutional guidelines for animal care and use.

Conclusion: It seems that both histamine and dopaminergic D2 receptors not only play a part in the modulation of anxiety in the dorsal hippocampus of mice but also have demonstrated a complex interaction.