Public Health Dispatch: Outbreak of Escherichia coli O157:H7 and Campylobacter Among Attendees of the Washington County Fair -- New York, 1999

On September 3, 1999, the New York State Department of Health (NYSDOH) received reports of at least 10 children hospitalized with bloody diarrhea or Escherichia coli O157:H7 infection in counties near Albany, New York. All of the children had attended the Washington County Fair, which was held August 23-29, 1999; approximately 108,000 persons attended the fair during that week. Subsequently, fair attendees infected with Campylobacter jejuni also were identified. An ongoing investigation includes heightened case-finding efforts, epidemiologic and laboratory studies, and an environmental investigation of the Washington County fairgrounds. This report presents the preliminary findings implicating contaminated well water.

As of September 15, 921 persons reported diarrhea after attending the Washington County Fair. Stool cultures yielded E. coli O157:H7 from 116 persons; 13 of these persons were co-infected with C. jejuni. Stool cultures from 32 additional persons yielded only Campylobacter. Sixty-five persons have been hospitalized; 11 children have developed hemolytic uremic syndrome (HUS); and two persons died: a 3-year-old girl from HUS and a 79-year-old man from HUS/thrombotic thrombocytopenic purpura. Cases of diarrheal illness among fair attendees have been reported from 14 New York counties and four states.

An environmental investigation of the fairgrounds on September 3 determined that much of the fair was supplied with chlorinated water. However, in at least one area of the fair, a shallow well supplied unchlorinated water to several food vendors who used the water to make beverages and ice. Initial cultures of water from this well yielded high levels of coliforms and E. coli.

A case-control study was conducted to determine risk factors for infection. Case-patients were residents of Washington County who developed diarrhea after attending the fair and in whom stool cultures yielded E. coli O157:H7 or Campylobacter. Controls were residents of Washington County randomly selected from the telephone directory who had attended the fair and were frequency-matched by age group. Thirty-two case-patients and 84 controls were enrolled. Analysis was limited to those attending the fair at least once during the final 4 days of the fair because all ill persons, including those attending only once, attended during that period. Drinking water or beverages made with water from the suspect well was associated with illness. Twenty-six (81%) of 32 case-patients and nine (16%) of 57 controls had consumed water from this well during the final 4 days of the fair (matched odds ratio=23.3; 95% confidence interval=6.3-86.9). When controlled for water consumption, other exposures, such as eating food at the fair and contact with manure, were not significantly associated with illness.

On September 9, the New York State Public Health Laboratory, the Wadsworth Center, used five different polymerase chain reaction assays to demonstrate the presence of E. coli O157:H7 DNA in water from the implicated well and subsequently isolated the organism from water samples from the well and the water distribution system. Pulsed-field gel electrophoresis testing by the Wadsworth Center showed that the DNA "fingerprints" of E. coli O157:H7 isolates from the well, the water distribution system, and most patients were similar. Water sampling for Campylobacter spp. is ongoing.

To prevent secondary transmission of enteric infection, letters were sent to schools and day care centers emphasizing the need to exclude symptomatic children and practice careful handwashing. Letters also were sent to nursing homes and hospitals with recommendations regarding employees and residents with diarrhea. Information to the public about the outbreak also focused on how to prevent secondary infections. On September 13, the state health commissioner issued an order requiring county fairgrounds to use disinfected water when hosting public events; the commissioner also is reviewing laws and regulations applicable to fairs.

Reported by: County health depts in the Capital District; New York state outbreak investigation team; A Novello, MD, Commissioner, New York State Dept of Health. Foodborne and Diarrheal Diseases Br, Div of Bacterial and Mycotic Diseases, National Center for Infectious Diseases; and EIS officers, CDC.

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