The entire planet is thrown into mayhem when millions of people disappear without a trace — all that remains are their clothes and belongings. Unmanned vehicles crash and planes fall from the sky, overwhelming emergency forces and causing massive gridlock, riots and chaos. Airline pilot Ray Steele (Nicolas Cage) struggles to save the lives of the passengers who remain on his flight, while his daughter (Cassi Thomson) races to find her brother and mother, both of whom have disappeared.