Product Directions / Additional Info

For best results, begin taking Wellness Formula capsules at the very first signs of imbalances in your well-being. During imbalance, take 6 capsules every 3 hours, do not exceed 30 capsules daily for a maximum of 10 days. For wellness maintenance, take up to 6 capsules daily.

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Use Arnicare at the First Sign of Pain
Arnicare Gel has a cooling effect for fast pain relief. Quickly absorbed by the skin Non-Greasy Unscented Paraben-free For general pain relief, Arnica 30C pellets can be taken alone or as complement ...

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This scientific independent research is provided by Aisle7 and is for informational use only. GNC provides this information as a service but does not endorse it. Likewise, Aisle7 does not recommend or endorse any specific products.

For an herb, supported by traditional use but minimal or no scientific evidence. For a supplement, little scientific support.

Our proprietary "Star-Rating" system was developed to help you easily understand the amount of scientific support behind each supplement in relation to a specific health condition. While there is no way to predict whether a vitamin, mineral, or herb will successfully treat or prevent associated health conditions, our unique ratings tell you how well these supplements are understood by the medical community, and whether studies have found them to be effective for other people.

For over a decade, our team has combed through thousands of research articles published in reputable journals. To help you make educated decisions, and to better understand controversial or confusing supplements, our medical experts have digested the science into these three easy-to-follow ratings. We hope this provides you with a helpful resource to make informed decisions towards your health and well-being.

This supplement has been used in connection with the following health conditions:

Dose: 1,000 mg daily boswellia resin herbal extract or two capsules, three times per day of Aticulin-F (formula containing 100 mg boswellia, 450 mg ashwagandha, 50 mg turmeric, and 50 mg zinc)
A combination of boswellia, ashwagandha, turmeric, and zinc effectively treated pain and stiffness in one study, without the stomach irritation that is a common side effect of NSAIDs.(more)

Osteoarthritis

Dose: Refer to label instructionsIn a double-blind trial, supplementation with curcuminoids significantly improved pain and overall functioning in people with osteoarthritis of the knee.(more)

Rheumatoid Arthritis

Dose: 400 mg of curcumin three times dailyTurmeric's active constituent, curcumin, is a potent anti-inflammatory compound that protects the body against free radical damage.(more)

Dose: 500 mg four times per day, for indigestionIn a double-blind trial, turmeric was found to relieve indigestion.(more)

Ulcerative Colitis

Dose: Refer to label instructionsCurcumin, a compound in turmeric, is anti-inflammatory and may improve symptoms of ulcerative colitis.(more)

Crohn's Disease

Dose: Refer to label instructionsTurmeric contains curcumin, which has been reported to have anti-inflammatory activity. In one study, people given turmeric saw an improvement after three months.(more)

Dose: Refer to label instructionsTurmeric has anti-inflammatory effects. One trial found curcumin (from turmeric) was more effective than anti-inflammatory medication for relieving postsurgical inflammation.(more)

HIV and AIDS Support

Dose: Refer to label instructionsTurmeric may be a useful herb with immune effects in people infected with HIV. One trial found that curcumin, turmeric's main active compound, helped improve CD4+ cell counts.(more)

Boswellia has anti-inflammatory properties that have been compared to those of the NSAIDs used by many for inflammatory conditions.1 Clinical trials have found that boswellia is more effective than a placebo for relieving pain and swelling and preventing loss of function in people with osteoarthritis.2 Boswellia has also been found to be as effective as the anti-inflammatory drug valdecoxib (Bextra). In addition, while the improvements occurred more slowly in the boswellia group than in the valdecoxib group, they persisted for a longer period of time after treatment was discontinued.3 One clinical trial found that a combination of boswellia, ashwagandha, turmeric, and zinc effectively treated pain and stiffness associated with OA but did not improve joint health, according to X-rays of the affected joint.4 Unlike NSAIDs, long-term use of boswellia does not lead to irritation or ulceration of the stomach.

Dose: Refer to label instructionsCurcuminoids are a group of compounds (including curcumin) present in turmeric. These compounds are known to have anti-inflammatory actions and to protect joint cartilage from damage. In a double-blind trial, supplementation with 500 mg of curcuminoids 3 times per day significantly improved pain and overall functioning, compared with a placebo, in people with osteoarthritis of the knee.1

Turmeric is a yellow spice often used to make curry dishes. The active constituent, curcumin, is a potent anti-inflammatory compound that protects the body against free radical damage.1 A double-blind trial found curcumin to be an effective anti-inflammatory agent in RA patients.2 The amount of curcumin usually used is 400 mg three times per day.

Ginger is another Ayurvedic herb used to treat people with arthritis. A small number of case studies suggest that taking 6-50 grams of fresh or powdered ginger per day may reduce the symptoms of RA.3 A combination formula containing ginger, turmeric, boswellia, and ashwagandha has been shown in a double-blind trial to be slightly more effective than placebo for RA;4 the amounts of herbs used in this trial are not provided by the investigators.

Turmeric is another herb known traditionally for its anti-inflammatory effects, a possible advantage for people suffering from low back pain. Several preliminary studies confirm that curcumin, one active ingredient in turmeric, may decrease inflammation in both humans1 and animals.2, 3 In one double-blind trial, a formula containing turmeric, other herbs, and zinc significantly diminished pain for people with osteoarthritis.4 Standardized extracts containing 400 to 600 mg of curcumin per tablet or capsule are typically taken three times per day. For tinctures of turmeric, 0.5 to 1.5 ml three times per day are the usual amount.

While there have been few studies on herbal therapy for bursitis, most practitioners would consider using anti-inflammatory herbs that have proven useful in conditions such as rheumatoid arthritis. These would include boswellia, turmeric, willow, and topical cayenne ointment.

Dose: Refer to label instructionsIn a double-blind study of patients suffering from depression, the combination of antidepressant medication and curcuminoids (substances present in turmeric) given for 6 weeks improved depression to a significantly greater extent than antidepressant medication alone. The product used in the study provided daily 1,000 mg of curcuminoids plus 10 mg of piperine (a substance in black pepper that is thought to increase the absorption of curcuminoids.)1 In another study, supplementation with 1,000 mg per day of curcumin (one of the substances present in turmeric) for 8 weeks significantly improved depression, compared with a placebo, in patients suffering from depression. In that study, about one-third of the participants were taking an antidepressant medication.2 In another double-blind study, supplementation with 1,000 mg per day of curcumin enhanced the beneficial effect of antidepressant medication.3

Carminatives (also called aromatic digestive tonics or aromatic bitters) may be used to relieve symptoms of indigestion, particularly when there is excessive gas. It is believed that carminative agents work, at least in part, by relieving spasms in the intestinal tract.1

In a double-blind trial, the spice turmeric was found to relieve indigestion.2 Two capsules containing 250 mg turmeric powder per capsule were given four times per day.

Curcumin is a compound in turmeric(Curcuma longa) that has been reported to have anti-inflammatory activity. In a preliminary trial, five of five people with chronic ulcerative proctitis (a condition similar to ulcerative colitis) had an improvement in their disease after supplementing with curcumin. The amount of curcumin used was 550 mg twice a day for one month, followed by 550 mg three times a day for one month.1 In a double-blind trial, supplementation with curcumin in the amount of 1 gram twice a day for six months decreased the relapse rate in patients with ulcerative colitis in remission. The relapse rate was 4.7% among people receiving curcumin and 20.5% in the placebo group, a statistically significant difference. All patients in the study also received conventional therapy.2

Curcumin is a compound in turmeric (Curcuma longa) that has been reported to have anti-inflammatory activity. In a preliminary trial, four of five people with Crohn's disease had an improvem ent in their condition after supplementing with curcumin for three months. The amount used was 360 mg three times a day for one month, followed by 360 mg four times a day for two months.1

Turmeric's active compound curcumin has shown potent anti-platelet activity in animal studies.1 It has also demonstrated this effect in preliminary human studies.2 In a similar vein, bilberry has been shown to prevent platelet aggregation3 as has peony.4 However, none of these three herbs has been documented to help atherosclerosis in human trials.

Turmeric is another herb known traditionally for its anti-inflammatory effects, a possible advantage for people suffering from low back pain. Several preliminary studies confirm that curcumin, one active ingredient in turmeric, may decrease inflammation in both humans1 and animals.2, 3 In one double-blind trial, a formula containing turmeric, other herbs, and zinc significantly diminished pain for people with osteoarthritis.4 Standardized extracts containing 400 to 600 mg of curcumin per tablet or capsule are typically taken three times per day. For tinctures of turmeric, 0.5 to 1.5 ml three times per day are the usual amount.

Dose: Refer to label instructionsIn a double-blind trial, supplementation with curcumin (the active ingredient in turmeric) significantly improved symptoms of PMS, compared with a placebo. The amount of curcumin used was 100 mg twice a day, starting 7 days before menstruation and continuing for 3 days after the start of menstrual bleeding. This treatment was repeated each month for a total of 3 months.1

Dose: Refer to label instructionsIn a double-blind trial, supplementation with curcumin (the active ingredient in turmeric) significantly improved symptoms of PMS, compared with a placebo. The amount of curcumin used was 100 mg twice a day, starting 7 days before menstruation and continuing for 3 days after the start of menstrual bleeding. This treatment was repeated each month for a total of 3 months.1

A recent study found that 24% of surgery patients had taken herbal supplements before their surgeries, and 50 different herbs had been used among these patients.1 Little research exists, however, on the safety or efficacy of herbs before surgery. Some researchers and healthcare providers are concerned about possible harmful interactions between herbs and medications used around or during surgery, or the possibility that some herbs may increase bleeding during and after surgery.2, 3 The use of herbs around the time of surgery should be discussed with a knowledgeable healthcare practitioner.

Turmeric(Curcuma longa) is an herb with anti-inflammatory effects.4 One trial found curcumin (from turmeric) at 400 mg three times daily was more effective than either placebo or anti-inflammatory medication for relieving post-surgical inflammation. However, as the different treatment groups had different degrees of inflammation at the start of the study, firm conclusions cannot be drawn from this study.5

3. Robb-Nicholson C. By the way, doctor. My surgeon advised me to stop taking gingko biloba before my hip surgery. Can you explain why? Are there any other herbs I should avoid? Harv Womens Health Watch 2000;7:8.

Turmeric may be another useful herb with immune effects in people infected with HIV. One preliminary trial found that curcumin, the main active compound in turmeric, helped improve CD4+ cell counts.1 The amount used in this study was 1 gram three times per day by mouth. These results differed from those found in a second preliminary trial using 4.8 or 2.7 grams of curcumin daily. In that study, there was no apparent effect of curcumin on HIV replication rates.2

Dose: Refer to label instructionsPreliminary research indicates a possible benefit of oral curcumin supplementation (375 mg of turmeric extract with 95% curcuminoids three times daily for 12 weeks) for chronic anterior uveitis (inflammation of the iris and middle coat of the eyeball).1

The information presented by Healthnotes is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. Self-treatment is not recommended for life-threatening conditions that require medical treatment under a doctor's care. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires June 2017.