After his capture of Miletus in 334 BC, Alexander the Great reconsecrated the oracle but placed its administration of the oracle in the hands of the city, where the priest in charge was annually elected.

About 300 BC, Seleucus I Nicator brought the bronze cult image back, and the Milesians began to build a new temple, which, if it had ever been completed, would have been the largest in the Hellenic world.

A closer examination brought the first ancient blueprint of a temple back to life.Mythic genealogies of the origins of the Branchidae line of priests, designed to capture the origins of Didyma as a Hellenic tradition, date to the Hellenistic period.Didyma was the largest and most significant sanctuary on the territory of the great classical city Miletus.To approach it, visitors would follow the Sacred Way to Didyma, about 17 km long.Along the way, were ritual waystations, and statues of members of the Branchidae family, male and female, as well as animal figures.Vitruvius recorded a tradition that the architects were Paeonius of Ephesus, whom Vitruvius credited with the rebuilding of the Temple of Artemis there, and Daphnis of Miletus.