The last few decades have witnessed a substantial increase in the use of smokeless tobacco (ST) products. The characterization of new ST products is vital to understanding their rise in popularity and the consequences of their use. The current study administered a series of cross-over trials to rapidly characterize the abuse liability and likelihood of adoption of a variety of ST products. Trial 1 compared subjective responses to a diverse range of ST such as snuff, snus, dissolvable, chewable, and medicinal products. In Trial 2, reported here, 30 ST users used General Classic Blend Swedish snus, Copenhagen moist snuff, Hawken Rough moist snuff wintergreen, Red Man moist snuff wintergreen, or Nicorette lozenges (control product) on each of five separate laboratory visits. Differences between products in self-reported liking, change in craving, and change in withdrawal were measured. Repeated measures mixed model analysis revealed significant differences between products in overall reinforcement (p