This book describes how systems biology, pharmacogenomic and behavioral approaches, as applied to neurodevelopmental toxicology, provide a structure to arrange information in a biological model. Authors review and discuss approaches that can be used as effective tools to dissect mechanisms underlying pharmacological and toxicological phenomena associated with the exposure to drugs or environmental toxicants during development. This book presents cross-cutting research tools and animal models, along with applications to the studies associated with potential anesthetic-induced developmental neurotoxicity; the developmental basis of adolescent or adult onset of disease; risk assessment of methyl mercury and its effects on neurodevelopment; challenges in the field to identify environmental factors of relevance to autism; and the strategy and progress of epilepsy research.

Cheng Wang is Senior Neurobiologist in the Division of
Neurotoxicology at the National Center for Toxicological Research,
U.S. Food and DrugAdministration. He is the author of over
fifty-five peer-reviewed publications and book chapters. Dr. Wang
was awarded the Outstanding Performance Award at the Society of
Toxicology 44th Annual Meeting and the 2007 FDA Scientific
Achievement Award for Excellence in Laboratory Science.

William Slikker, Jr., is the Director of the National
Center for Toxicological Research, U.S. Food and Drug
Administration. He has over 260 peer-reviewed scientific
publications. Dr. Slikker has served as coeditor of several books
and is an Associate Editor of the journals NeuroToxicology
and Toxicological Sciences.

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