My thoughts, feelings, and opinions, as yes, though in continuous agonizing pain, underweight for six foot, I can think. And feel. And wonder why they treat this the way they do. I don't run and if I walk, not on a wheel.

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Wednesday, August 15, 2012

Medical Marijuana and Chronic Pain

As many as one in five Americans lives
with chronic pain. Many of these people suffer from neuropathic pain
(nerve-related pain) -- a condition that is associated with numerous
diseases, including diabetes, cancer, multiple sclerosis,
and HIV. In most cases, the use of standard analgesic medications such
as opiates and NSAIDS (non-steroidal anti-inflammatory drugs) is
ineffective at relieving neuropathic pain.

Survey
data indicates that the use of cannabis is common in chronic pain
populations, and several recent clinical trials indicate that inhaled
marijuana can significantly alleviate neuropathic pain. A pair of
clinical trials recently demonstrated that smoking cannabis reduces
neuropathic pain in patients with HIV by more than 30 percent compared
to placebo.

In 2008 investigators at the University of California
at Davis assessed the efficacy of inhaled cannabis on pain intensity
among 38 patients with central or peripheral neuropathic pain in a
randomized, placebo-controlled, crossover trial. They reported:
"[C]annabis reduced pain intensity and unpleasantness equally. Thus, as
with opioids, cannabis does not rely on a relaxing or tranquilizing
effect, but rather reduces both the core component of nociception (nerve
pain) and the emotional aspect of the pain experience to an equal
degree."

Preclinical data indicates that cannabinoids, when
administered in concert with one another, are more effective at
ameliorating neuropathic pain than the use of a single agent.
Investigators at the University of Milan reported in 2008 that the
administration of single cannabinoids such as THC or CBD produce limited
relief compared to the administration of plant extracts containing
multiple cannabinoids, terpenes (oils), and flavonoids (pigments).

Researchers
concluded: "[T]he use of a standardized extract of Cannabis sativa ...
evoked a total relief of thermal hyperalgesia, in an experimental model
of neuropathic pain, ... ameliorating the effect of single
cannabinoids," investigators concluded. ... "Collectively, these
findings strongly support the idea that the combination of cannabinoid
and non-cannabinoid compounds, as present in [plant-derived] extracts,
provide significant advantages in the relief of neuropathic pain
compared with pure cannabinoids alone."

In 2009, an international
team of investigators from the United Kingdom, Belgium, and Romania
affirmed these preclinical findings in a clinical study of intractable
cancer pain patients. They concluded: "[I]n this study, the THC/CBD
extract showed a more promising efficacy profile than the THC extract
alone. This finding is supported by evidence of additional synergy
between THC and CBD. CBD may enhance the analgesic potential of THC by
means of potent inverse agonism at CB2 receptors, which may produce
anti-inflammatory effects, along with its ability to inhibit immune cell
migration. ... These results are very encouraging and merit further study."

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About Me

I am me. I am 37, and I come from a borderline/narcissistic mother, and a drunk for a father. I want to tell my story, but I live many days in severe pain so I might be grumpy when I am only trying to be straight up and tell it as is. I believe in GOD, and that if you are going to ask for ASSISTANCE from the AMERICAN government, please do it in our OFFICIAL LANGUAGE OF ENGLISH. This country was founded for the freedom to practice Christian beliefs without being persecuted for it, and so if you don't like what I have to say, please see the FIRST AMMENDMENT TO THE CONSTITUTION (before obama changes it)