Hypertensive crisis (most notably with ingestion of tyramine, which is found in many foods such as wine and cheese); CNS stimulation. Contraindicated with SSRIs, TCAs, St. John’s wort,meperidine, dextromethorphan (to prevent serotonin syndrome)

Atypical antidepressants are

Bupropion

Mirtazapine

Trazodone

Bupropion moa and toxicity

Also used for smoking cessation.  inc norepinephrine and dopamine via unknown mechanism.