William Hague today said he hoped he had "nailed" rumours that he had an improper relationship with a former special adviser.

The foreign secretary described the reports about him and Christopher Myers as a "big lie".

Last week, Hague released a deeply personal statement about his relationship with his wife, Ffion, in an attempt to kill off rumours of an affair with the 25-year-old adviser. He also announced Myers' resignation.

Hague wrote on Twitter last night: "Thanks for another day of very supportive comments. What was said about me was a big lie, which I hope has been nailed. I am enjoying my work."

Hague first spoke out last week after rumours about his relationship with Myers had been circulating.

Photos of Hague and Myers walking together in casual clothes were published in the Mail on Sunday, and the Guido Fawkes political website made a freedom of information request about the appointment of the adviser, who has little apparent expertise in foreign affairs.

The website also disclosed that Myers and Hague had shared a hotel room at least once.

The foreign secretary's tweet may raise further questions about his handling of the rumours. When he issued his statement last week, it was picked up by the media, which had ignored the story up to that point.

The public relations guru Max Clifford said the statement had turned a "small problem into a huge problem".

Hague admitted last week that he had "occasionally shared twin hotel rooms" with Myers but said: "Any suggestion that his appointment was due to an improper relationship between us is utterly false."

In the statement he also revealed his wife had "suffered multiple miscarriages, and indeed we are still grieving for the loss of a pregnancy this summer".

Many Tories are uncomfortable with Hague's handling of the affair and believe it was wrong to appoint Myers as his third special adviser when he has little apparent expertise in foreign affairs. Cabinet ministers usually have only two special advisers.

The former cabinet minister and failed Tory leadership contender John Redwood wrote on his blog that Hague had shown "poor judgment" in sharing a hotel room with Myers.