Expertise

Research Interests

Biography

Dr. Luis Andres Garza is an associate professor of dermatology at the Johns Hopkins University School of Medicine. His areas of clinical expertise include wound care and general dermatology.

Dr. Garza received his undergraduate degree in neurobiology from Cornell University. He earned his M.D. and Ph.D. together from the medical scientist training program at the University of Pennsylvania School of Medicine. Dr. Garza completed his residency in dermatology at the University of Michigan and performed his fellowship in dermatology at the University of Pennsylvania. He joined the Johns Hopkins faculty in 2009.

In addition to treating patients, Dr. Garza runs a molecular biology laboratory that studies skin stem cells and wound healing with an emphasis on identifying the next generation of wound therapeutics and diagnostics.

Dr. Garza is an associate editor for the Journal of Investigative Dermatology. He is a member of the American Academy of Dermatology, the Society for Investigative Dermatology and the North American Clinical Dermatology Society.

Residencies

Certifications

Research Summary

Dr. Garza runs a molecular biology laboratory that studies skin stem cells and wound healing with an emphasis on identifying the next generation of wound therapeutics and diagnostics.

While at the University of Pennsylvania, Dr. Garza and Dr. George Cotsarelis discovered that prostaglandins might be the catalyst that causes baldness. They also pinpointed the receptor on the prostaglandin cell, making it a target for possible future therapies for male pattern baldness.

Lab:

Our group is interested in investigating hypotheses on basic skin questions that are directly relevant to skin disease in humans. We hope that through rigorous hypothesis-driven research into skin biology, we will gain important insights that will directly improve patient care.

Our model system is the skin. To answer basic questions regarding stem cell biology and regeneration, we choose the skin because of its accessibility, the depth of current knowledge, and the complexity of epithelial/mesenchymal interactions in the context of relevant vasculature, nerves and hematopoietic cells.

The current focus of the lab is what controls and maintains skin identity. Regions of our skin are remarkably diverse in function and features. Despite constant cellular turnover, each area’s features are remarkably maintained. We study how, under normal conditions, identity is actively maintained and how it might be manipulated. We also study how, during wounding, skin identity is typically lost (i.e., scar), but in rare situations complete regeneration occurs.

Understanding these questions will have broad significance to regeneration and stem cell biology in multiple organs. Understanding wound healing programs that re-initiate embryonic developmental patterns might eventually lead to insights on how to trigger the re-growth of a severed human limb, for example.