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Because of potential antagonism, chloramphenicol should not be administered simultaneously with penicillin or streptomycin.

WARNING:

NOT FOR USE IN ANIMALS WHICH ARE RAISED FOR FOOD PRODUCTION. CHLORAMPHENICOL PRODUCTS SHOULD NOT BE ADMINISTERED IN CONJUNCTION WITH OR 2 HOURS PRIOR TO THE INDUCTION OF GENERAL ANESTHESIA WITH PENTOBARBITAL BECAUSE OF PROLONGED RECOVERY.
CHLORAMPHENICOL PRODUCTS SHOULD NOT BE ADMINISTERED TO DOGS MAINTAINED FOR BREEDING PURPOSES. SOME EXPERIMENTS INDICATE THAT CHLORAMPHENICOL CAUSES IN EXPERIMENTAL ANIMALS, PARTICULARLY IN FEMALES, SIGNIFICANT DISORDERS IN MORPHOLOGY AS WELL AS IN FUNCTION OF THE GONADS.

HAZARDS AND PRECAUTIONS:

1. This antibiotic contains a chemical structure nitrobenzene group that is characteristic of a group of drugs long known to depress hematopoietic activity of the bone marrow 54.
2. In vitro-tissue culture studies using canine bone marrow cells have demonstrated that extremely high concentrations of chloramphenicol inhibit both uptake of iron by the nucleated red cells and incorporation of iron into heme 55.
3. Chloramphenicol products should not be administered in conjunction with or two hours prior to the induction of general anesthesia with pentobarbital because of prolonged recovery time.
4. Chloramphenicol products should not be administered to dogs maintained for breeding purposes. Some experiments indicate that chloramphenicol causes, in experimental animals, particularly females, significant disorders in morphology as well as in function of the gonads.

ADVERSE REACTIONS:

Certain individual dogs may exhibit transient vomiting or diarrhea after an oral dose of 25 mg/lb body weight 49.
keep out of reach of children.