There exist two separate branches of finance that require advanced quantitative techniques: derivatives pricing, and risk and portfolio management. One of the main differences is that they use different probabilities, namely the risk-neutral probability (or arbitrage-pricing probability), denoted by "Q", and the actual (or actuarial) probability, denoted by "P".

Once a fair price has been determined, the sell-side trader can make a market on the security. Therefore, derivatives pricing is a complex "extrapolation" exercise to define the current market value of a security, which is then used by the sell-side community. Quantitative derivatives pricing was initiated by Louis Bachelier in The Theory of Speculation (published 1900), with the introduction of the most basic and most influential of processes, the Brownian motion, and its applications to the pricing of options. Bachelier modeled the time series of changes in the logarithm of stock prices as a random walk in which the short-term changes had a finite variance. This causes longer-term changes to follow a Gaussian distribution.[3]

A process satisfying (1) is called a "martingale". A martingale does not reward risk. Thus the probability of the normalized security price process is called "risk-neutral" and is typically denoted by the blackboard font letter "Q{\displaystyle \mathbb {Q} }".

The relationship (1) must hold for all times t: therefore the processes used for derivatives pricing are naturally set in continuous time.

The quants who operate in the Q world of derivatives pricing are specialists with deep knowledge of the specific products they model.

Securities are priced individually, and thus the problems in the Q world are low-dimensional in nature. Calibration is one of the main challenges of the Q world: once a continuous-time parametric process has been calibrated to a set of traded securities through a relationship such as (1), a similar relationship is used to define the price of new derivatives.

Risk and portfolio management aims at modeling the statistically derived probability distribution of the market prices of all the securities at a given future investment horizon.
This "real" probability distribution of the market prices is typically denoted by the blackboard font letter "P{\displaystyle \mathbb {P} }", as opposed to the "risk-neutral" probability "Q{\displaystyle \mathbb {Q} }" used in derivatives pricing.
Based on the P distribution, the buy-side community takes decisions on which securities to purchase in order to improve the prospective profit-and-loss profile of their positions considered as a portfolio.

The portfolio-selection work of Markowitz and Sharpe introduced mathematics to investment management. With time, the mathematics has become more sophisticated. Thanks to Robert Merton and Paul Samuelson, one-period models were replaced by continuous time, Brownian-motion models, and the quadratic utility function implicit in mean–variance optimization was replaced by more general increasing, concave utility functions.[6] Furthermore, in more recent years the focus shifted toward estimation risk, i.e., the dangers of incorrectly assuming that advanced time series analysis alone can provide completely accurate estimates of the market parameters.[7]

Much effort has gone into the study of financial markets and how prices vary with time. Charles Dow, one of the founders of Dow Jones & Company and The Wall Street Journal, enunciated a set of ideas on the subject which are now called Dow Theory. This is the basis of the so-called technical analysis method of attempting to predict future changes. One of the tenets of "technical analysis" is that market trends give an indication of the future, at least in the short term. The claims of the technical analysts are disputed by many academics.

In general, modeling the changes by distributions with finite variance is, increasingly, said to be inappropriate.[11] In the 1960s it was discovered by Benoît Mandelbrot that changes in prices do not follow a Gaussian distribution, but are rather modeled better by Lévy alpha-stable distributions.[12] The scale of change, or volatility, depends on the length of the time interval to a power a bit more than 1/2. Large changes up or down are more likely than what one would calculate using a Gaussian distribution with an estimated standard deviation. But the problem is that it does not solve the problem as it makes parametrization much harder and risk control less reliable.[8]