Aliskiren, Amlodipine And Hydrochlorothiazide

treats high blood pressure. This medication has three components, aliskiren, amlodipine, and hydrochlorothiazide. Do not take during pregnancy.

Aliskiren, Amlodipine And Hydrochlorothiazide Overview

Updated: June 7, 2016

Aliskiren/amlodipine/hydrochlorothiazide is a prescription medication used to treat high blood pressure. It is a single product containing 3 medications: aliskiren, amlodipine, and hydrochlorothiazide. Aliskiren belongs to a group of drugs called renin inhibitors, which work by reducing renin production in the body to reduce blood pressure. Amlodipine belongs to a group of drugs called calcium channel blockers, which help relax blood vessels. This makes it easier for the heart to pump blood. Hydrochlorothiazide belongs to a group of drugs called thiazide diuretics, which work by stopping reabsorption of salt into your body. This prevents fluid from building up in the body.

This medication comes in tablet form and is typically given once daily with or without food. Make sure to take it the same way every time. For example, always take it with food or always take it without food.

Common side effects of aliskiren/amlodipine/hydrochlorothiazide include retaining fluid (edema), headache, and infection of the nose and throat (nasopharyngitis).

Aliskiren/amlodipine/hydrochlorothiazide can also cause tiredness and dizziness. Do not drive or operate heavy machinery until you know how this medication affects you.

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Aliskiren, Amlodipine And Hydrochlorothiazide Interactions

No drug interactions have been evaluated by the manufacturer for the combination of aliskiren/amlodipine/hydrochlorothiazide. However, you should tell your doctor about all the medicines you take including prescription and nonprescription medicines, vitamins and herbal supplements. Not all drug interactions are known or reported and new drug interactions are continually being reported. Medicines that may cause interactions due to the medicines in aliskiren/amlodipine/hydrochlorothiazide include the following:

a kind of medicine to control blood pressure called an angiotensin receptor blocker (ARB) or angiotensin-converting enzyme inhibitor (ACEI)

Aliskiren, Amlodipine And Hydrochlorothiazide Precautions

Serious side effects have been reported with aliskiren/amlodipine/hydrochlorothiazide or its ingredients including the following:

Allergic reactions. Tell your healthcare provider right away if you have some or all of the following symptoms:

swelling of the face, limbs, lips, tongue, throat

difficulty breathing

stomach (abdominal) pain (intestinal angioedema) with or without nausea or vomiting

Harm to an unborn baby (fetal toxicity). Do not take this medication if you are pregnant or will become pregnant.

Low blood pressure (hypotension). Your blood pressure may get too low if you also take water pills, are on a low-salt diet, get dialysis treatments, have heart problems, or get sick with vomiting or diarrhea. Drinking alcohol and taking certain medicines (barbiturates or narcotics) can cause low blood pressure to get worse. Lie down if you feel faint or dizzy, and call your doctor right away.

Worsening chest pain or heart attack. When you first start taking aliskiren/amlodipine/hydrochlorothiazide or increase your dose, you may have a heart attack or your angina may get worse. If that happens, call your doctor right away or go directly to the nearest hospital emergency room.

Eye problems. One of the medicines in aliskiren/amlodipine/hydrochlorothiazide can cause eye problems that may lead to vision loss. Symptoms of eye problems can happen within hours to weeks of starting this medication. Tell your doctor right away if you have:

decrease in vision

eye pain

Kidney impairment or failure. Aliskiren, one of the medicines in aliskiren/amlodipine/hydrochlorothiazide, may cause kidney disorder with symptoms such as severely decreased urine output or decreased urine output.

Imbalances in the levels of salts and fluids in your body (electrolyte and fluid imbalance). Tell your healthcare provider right away if you have some or all of the following symptoms:

dry mouth

thirst

weakness

drowsiness

restlessness

muscle pains or cramps

low blood pressure

low output of urine

fast heart rate

nausea

vomiting

Aliskiren/amlodipine/hydrochlorothiazide can cause tiredness and dizziness. Do not drive or operate heavy machinery until you know how aliskiren/amlodipine/hydrochlorothiazide affects you.

Do not take aliskiren/amlodipine/hydrochlorothiazide if you:

are allergic to aliskiren, hydrochlorothiazide, amlodipine, other medicines that contain sulfonamide, or any other ingredients in aliskiren/amlodipine/hydrochlorothiazide

have diabetes and are taking a kind of medicine called an angiotensin receptor blocker (ARB) or angiotensin-converting enzyme inhibitor (ACEI)

your kidneys do not produce urine (anuria)

Aliskiren, Amlodipine And Hydrochlorothiazide Food Interactions

Medications can interact with certain foods. In some cases, this may be harmful and your doctor may advise you to avoid certain foods. In the case of aliskiren/amlodipine/hydrochlorothiazide, salt substitutes containing potassium should be avoided.

Aliskiren, Amlodipine And Hydrochlorothiazide and Pregnancy

The FDA categorizes medications based on safety for use during pregnancy. Five categories - A, B, C, D, and X, are used to classify the possible risks to an unborn baby when a medication is taken during pregnancy.

Aliskiren/amlodipine/hydrochlorothiazide falls into category D. When pregnancy is detected, discontinue aliskiren/amlodipine/hydrochlorothiazide as soon as possible. Drugs that act directly on the renin-angiotensin system can cause injury and death to the unborn baby.

Aliskiren, Amlodipine And Hydrochlorothiazide and Lactation

It is not known whether aliskiren or amlodipine, two components of this medication, are excreted in human milk. Hydrochlorothiazide, the other component, has been detected in human breast milk. Because of the possibility for adverse reactions in nursing infants from aliskiren/amlodipine/hydrochlorothiazide, a choice should be made whether to stop nursing or to stop taking this medication. The importance of the drug to the mother should be considered.

Aliskiren, Amlodipine And Hydrochlorothiazide Usage

Take aliskiren/amlodipine/hydrochlorothiazide exactly as prescribed by your doctor.

It is important to take aliskiren/amlodipine/hydrochlorothiazide every day to control your blood pressure.

Take aliskiren/amlodipine/hydrochlorothiazide 1 time a day, at about the same time each day.

Take aliskiren/amlodipine/hydrochlorothiazide the same way every day, either with or without a meal.

Your doctor may change your dose of aliskiren/amlodipine/hydrochlorothiazide if needed. Do not change the amount of aliskiren/amlodipine/hydrochlorothiazide you take without talking to your doctor first.

If you miss a dose of aliskiren/amlodipine/hydrochlorothiazide, take it as soon as you remember. If it is close to your next dose, do not take the missed dose. Just take the next dose at your regular time

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