Paediatric european network for treatment aids

Detalles del proyecto

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CON - Coordination of research actions

Objetivo

The primary aim of PENTA is to evaluate new antiretroviral and immune therapies in children, and particularly to develop trials addressing important management issues, which cannot be assumed from results of trials in adults. Has established a network of paediatric centres and collaborating laboratories from 11 European countries to undertakemulticentre clinical trials. With the prolongation of disease-free life associated with potent antiretroviral therapy(ART), new therapies are evaluated in adult trials using endpoints of viral load reduction and immune response. However, there are important differences between adults and children in these parameters. Pharmacokinetic studies are essential as some drugs such as the protease inhibitors are metabolised faster in children and extrapolating from adult data would result in under dosing which could increase the risk of developing resistance to HIV. Increased collaboration with other international groups running studies in HIV infected children is planned for new trials and for undertaking meta-analyses. Collaboration and communication between clinical centres will be increased through pentad newsletter, training exchanges and the development of a PENTA website.