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Reversal Agents and NOAC-induced bleeding

The use of reversal agents for the management of NOAC-induced bleeding is described to be beneficial in three clinical settings: 1) A patient who presents to the Emergency Room with active emergent bleeding and requires urgent reversal (with agent that acts quickly), 2) Patients requiring urgent or emergent surgery (i.e., colon perforation), and 3) Patients at higher risk of heightened anticoagulant effect (i.e., overdose history, renal failure).

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