Abstract

This study was performed to determine the trend of antibiotic resistance of the causative organisms among the patients suffering from nosocomial infections in Besat Hospital since 2013 to 2015.In this observational study that was performed as a retrospective cohort, 935 consecutive patients with nosocomial infection were enrolled in Besat Hospital since 2013 to 2015. The trend of antibiotic resistance of the causative organisms among them was determined and contributing factors were assessed. The finding of this study revealed that type of microorganisms had significant variation (p = 0.024): while the gram-negative bacilli have shown an increased level of resistance, the gram positive cocci had less resistance. The antibiotic resistance was increased for ampicillin/sulbactam, piperacillin/tazoactam, ceftriaxone, ceftazidime, cefepime, meropenem, gentamicin, amikacin, ciprofloxacine, levofloxacine, nitrofurantoin, and ampicilline. However, it was decreased for colistin. It may be concluded that antibiotic resistance has an increasing trend and that strategic measures of prevention are needed to reduce nosocomial infections.