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In this issue, 2 reviews assess the effect of type and duration of thromboprophylaxis in patients undergoing major orthopedic surgery. Neumann and colleagues compared the efficacy and safety of thromboprophylaxis using oral direct factor Xa inhibitors or LMWH. Sobieraj and colleagues compared outcomes of prolonged versus standard-duration thromboprophylaxis after major orthopedic surgery. The editorialists discuss the findings and identify the remaining questions that future studies should address.

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If the surgery is performed in a teaching hospital - even one of the best - Surgical residents should always have their anticoagulation orders DOUBLE-CHECKED by the surgeon or another experienced MD before administration. I know of case in which the patient was put to risk by the fact that: a) the resident had not checked the patient's coagulation panel and b) the resident didn't know that some antidepressants tend to affect coagulation in the wrong direction...

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