Heart Rate Variability During Acute Diverticulitis

This study has been completed.

Sponsor:

Herlev Hospital

ClinicalTrials.gov Identifier:

NCT01840917

First Posted: April 26, 2013

Last Update Posted: February 25, 2014

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The purpose of this study is to investigate heart rate variability during Acute uncomplicated diverticulitis by ECG-monitor (Holter), the investigators hypothesis is the inflammation causes a decrease of High Frequency(HF)-power component of heart rate variability and this correlates with sleep quality and daytime fatigue.

Heart-rate variability changes during the acute uncomplicated diverticulitis compared to the baseline levels at 30th night where the condition has been cured [ Time Frame: 1st, 2nd and 30th night following the admission ]

Heart-rate variability measured by Holter monitor and a following analysis of frequency and time domain parameters.

Secondary Outcome Measures:

changes in plasma cytokine levels during the acute uncomplicated diverticulitis from the baseline levels at 30th day (remission) [ Time Frame: 1st, 2nd and 30th days following the admission ]

the blood sample is taken at night before sleep time. the cytokines are measured with ELISA-kit

change in Sleep data during the acute diverticulitis from baseline Sleep data at remission (30th day) [ Time Frame: 1st, 2nd and 30th days following the admission ]

Sleep data is measured by Polysomnography and sleep is categorized into sleep stages (awake, stage 1, 2, REM-sleep and SWS-sleep)

An increasing number of studies have shown that circadian variation in the excretion of hormones, the sleep-wake cycle, the core body temperature, the tone of the autonomic nervous system and the activity rhythm are important both in health and disease processes. The investigators are interested in investigating the heart rate variability (HRV) during an acute surgical non-inflammatory condition, and to exam whether there are correlations between: HRV and sleep stages, HRV and cytokine levels in blood and HRV and subjective fatigue.

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