ABSTRACTObjective: To report clinical features of chronic complications of adult Congolese sickle cell patients. Materials and methods. This was a cross-sectional descriptive study carried out over a period of one year (from 1 January 2016 to 31 December 2016) in the hematology department of the University Teaching Hospital of Brazzaville (Congo). We analyzed the type as well as the clinical and biological profile of adult sickle cell patients with chronic complications. Results. 144 patients were studied but only 95 of them (37 men and 58 women) came to the hospital for signs and symptoms related to their complications. Their mean age was 28.68 years. Hemolytic complications were found in 122 cases (85.32%) and among them, gallstones were present in 40.31% of cases while leg ulcer was present in 29.51% of cases. Aseptic osteonecrosis was the only diagnosed ischemic complication and it represented 14.68% of chronic complications. There was a statistically significant association between hemolytic complications and the presence of low hemoglobin rate (7.34 g / dl) or a high neutrophil cells count (9.1 G / L). Conclusion: Despite the improvement in the management of adult sickle cell patients, the frequency of chronic complications remains high. More studies are needed to assess their real frequency and risk factors of their appearance.