Application Information: NDUFS1 antibody, Internal

Not tested in other applications. *Optimal dilutions/concentrations should be determined by the researcher.

Predicted Target Size

79 kDa (note)

Positive Controls

The peptide used to generate this antibody is available for purchase (GTX88087-PEP).

Form Supplied

Liquid

Concentration

0.50
mg/ml
(Please refer to the vial label for the specific concentration)

Purification

Purified by ammonium sulphate precipitation followed by antigen affinity chromatography

Specifications: NDUFS1 antibody, Internal

Full Name

NADH:ubiquinone oxidoreductase core subunit S1

Background

The protein encoded by this gene belongs to the complex I 75 kDa subunit family. Mammalian complex I is composed of 45 different subunits. It locates at the mitochondrial inner membrane. This protein has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. This protein is the largest subunit of complex I and it is a component of the iron-sulfur (IP) fragment of the enzyme. It may form part of the active site crevice where NADH is oxidized. Mutations in this gene are associated with complex I deficiency. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

Synonyms

PRO1304 Antibody , CI75KD Antibody , CI75K Antibody

Host

Goat

Clonality

Polyclonal

Isotype

IgG

Immunogen

Peptide with sequence C-TEKSATYVNTEGR, from the internal region of the protein sequence according to NP_004997.4.