Marx Soul has nothing on this guy. It is literally impossible for me to beat it without stone... And EVEN THEN it's EXTREMELY HARD! It's really hard because of how FAST he is. Because Meta Knight wasn't hard enough...

53Red Falcon's Brain - Contra 3

54Henry - No More Heroes

If you want No More Heroes, be careful of his Instant Kill attack.

55Zero - Kirby's Dreamland 3

56Red - Pokémon Heartgold/Soulsilver

I had to get help from my brother because red kept hurling hail and charzard killed me

This guy has got to be the hardest boss I've ever faced. All of his Pokémon are at least level 80 with overpowered moves, not to mention there's hail (which hurts all Pokémon on the field, making it a double-edged sword), which his Lapras is immune to. I've only beaten Red with a Mewtwo, A.K.A. the cheater's Pokémon, and even then I only won because the hail killed his last Pokémon. He's much harder than in the Gameboy Color version; there, his Pokémon were 10 levels lower, there was no hail, the moves he could use were different, and he had an Espeon instead of a Lapras. Red is evil, no doubt.

57Another Joe - Viewtiful Joe

58Ballos - Cave Story

This boss is RIDICULOUSLY hard! I couldn't even believe it, when he first attacked he rammed into me and knocked off half my health and then flew around a bunch and stomped on me. He did this for a while, and then summoned lightning. Instant KO.