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Crumpled brows could be an early indicator of atherosclerosis, say researchers at an EU cardiology conference

People with very wrinkly foreheads are nearly 10 times more likely to die from cardiovascular disease (CVD) than those boasting smooth brows, according to a landmark study.
Horizontal brow wrinkles could therefore be a red flag that further assessment and advice was needed, the researchers reported at the European Society of Cardiology Congress in Munich over the weekend.

“Just looking at a person’s face could sound an alarm, then we could give advice to lower risk,” said study author Associate Professor Yolande Esquirol, from the occupational health department at the Centre Hospitalier Universitaire de Toulouse in France.

More than 3000 healthy French participants were recruited from the wider VISAT (Ageing, Health and Work) cohort, aged between 32 and 62 at baseline.

Their brow wrinkles were ranked from zero (no wrinkles) to three (numerous, deep wrinkles) at the start of the study.

Over the 20-year follow-up, the study authors found participants with wrinkle scores of 2-3 were 9.6 times more likely to die from cardiovascular disease than those with unlined foreheads.

Meanwhile, those with wrinkle scores of 1 had 5.7 times the CVD mortality.