This New York City couple have been living in sin since 2002, and they began their 5 days a week, New York Times-praised, radio show in March 2005. Their no-holds-barred show tackles literally everything as it is not bound by the rules of terrestrial radio. Out of well over 20,000 separate podcasts, Keith and The Girl immediately became, and remain, one of the most listened to radio shows of all time.