Murphy became a household name through Dave Chappelle's Comedy Central skit show thanks to his amazing stories of interactions with other celebrities during the height of his brother's fame in the 1980s. The most popular short turned into a skit about Rick James.

The comedian's Twitter account sent a final note on Tuesday evening that read: "One to Sleep On: Release the past to rest as deeply as possible."

Darkness. Deep and funny guy. Sheri loved the Rick James story so much. Irony here is that Charlie Murphy passed away while getting chemo. The very first night Sheri got chemo, which was a decision she agonized over, they had her sedated in advance of the side effects. The stuff (dope, not chemo) was just starting to hit her and she started to go from scared to getting a little giddy and we were passing quotes from the Rick James bit back and forth. I'm hitting her with this one line, it's a brutally politically incorrect line, and I say it once... nothing... again... still nothing... then one more time and bam... she starts snorting with laughter. And then she fell asleep. Charlie Murphy. Got her through her first night of chemo. May they all rest in peace.

Charlie heard about my nephew Baby Shawn, who has been battling DIPG and took out time during the tour to spend with him and his siblings. Like DL said, my eyes saw was something wrong. But I convinced myself he was on some crazy diet. My prayers and condolences to his family. Especially his children, who also lost their mother to cancer in 2009. #CANCERSUCKS