In Vivo And In Vitro Studies Of Anti-Cholesterol And Anti-Carcinogenic Effects Of Ganoderma Crud Extract

Abstract

The in vivo and in vitro effect of a local, commercially available Ganoderma fruiting
body powder (GF) and G. lucidum mycelium (GM) grown in soy waste on tumour and
hypercholesterolaemic rats were studied.
Administration of 1 % cholesterol diet in the cholesterol (Chol) group caused a significant
(p<O.05) increase in the serum total cholesterol (TC), triglyceride (TG) and low density
lipoprotein cholesterol (LDL-C) levels while reducing serum high density lipoprotein
cholesterol (HDL-C) level. In the case of the Chol+GF and Chol+GM groups, the initial
serum TC, TG and LDL-C levels showed a much higher levels (p<O.05) compared to the
Chol group. However, the levels gradually decreased towards the end of the experiment.
There was no significant difference in the lipid profiles amongst the Control, GF and GM
groups. Serum alanine transferase (AL T), gamma glutamyltransferase (GGT) and
creatine kinase (CK) in the Chol+GF group as well as the AL T, GGT level in the