Weeds: You Can't Miss the Bear(2005) [Judah Botwin]: Dies (off-screen) of a heart attack while jogging with his son (Alexander Gould), some time before the series starts. (Jeffrey does not appear in this opening episode, but the character's death is established; he has only appeared in videotape/flashback footage in the episodes Free Goat and Dead in the Nethers.) (Thanks to TS)

Supernatural: In My Time of Dying(2006) [John Winchester]: Dies of an apparent heart attack, after offering his life to a demon in exchange for saving the life of his son (Jensen Ackles). (Thanks to Bridget, TS, and Sara)

Watchmen(2009) [Edward Blake a.k.a. The Comedian]: Thrown through a window at the end of a fight with Matthew Goode. (Thanks to Agustin and Tommy)