CITSens Bio sensorsare electrochemical, enzyme-based sensors with the capacity to be used in defined cell culture media as well as in complex matrices, e.g. blood.

CITSens Bio sensors are based on screen printed electrodes which are coated with an immobilized enzyme. The sensor is built into the respective original cap or finished as a PEEK PG13.5 sensor, double packaged and subsequently sterilized by gamma-irradiation.

For implementation of the system, the CITSens Bio sensor is connected to the radio transmitter and put into the cell culture. Data measured are transmitted to the ZOMOFI radio receiver and transferred to the PC by means of LAN.

Continuous and disturbance-free measurement of key metabolic parameters such as glucose and lactate is critical for cell biologists, both in academia and industry. Using CITSens Bio or CITSens MeMo, cell growth and metabolic activity are measured instantaneously and such derived data can be used to trigger bioprocess control actions.

It is not only the sophisticated lab of a biopharmaceutical company that benefits from the features offered by the CITSens product line but also the many investigators in the different fields of basic cell biology research: Frequent manual interventions for sampling or optical examination harm cell cultures, disturb their growth, add risk of contamination and interfere with systematic investigation approaches. Some of the obvious negative aspects of disturbing growing cell cultures are: