It has been my pleasure to come home from the office every evening, sit at my desk, and continue reading Space Physiology, by Jay C. Buckey, Jr, MD. This outstanding book contains in succinct and clear language what we know today about the physiological aberrations that affect astronauts and others who venture into space. Dr Buckey describes the mechanisms of these aberrations and their countermeasures, including an honest appraisal of effectiveness and ineffectiveness. He closes each chapter with thoughtful recommendations for requisite future research.