DNA methylation patterns are altered in numerous diseases and often correlate with clinically relevant information such as disease subtypes, prognosis and drug response. With suitable assays and… (More)

Epigenetic modifications play an important role in modulating genome function. In mammals, inappropriate epigenetic states can cause embryonic lethality and various acquired and inherited diseases;… (More)

We present a model to explain the stochastic expression of the IFN-â gene from a single allele in a small population of cells. The choice of the allele to be expressed depends on interchromosomal… (More)