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Research provides clues to neurodevelopemental disorders

Date:

November 16, 2011

Source:

Society for Neuroscience

Summary:

Scientists are finding new tools to help understand neurodevelopmental disorders like autism and fragile X syndrome. Studies show in new detail how the brain's connections, chemicals, and genes interact to affect behavior.

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Scientists are finding new tools to help understand neurodevelopmental disorders like autism and fragile X syndrome. New studies show in new detail how the brain's connections, chemicals, and genes interact to affect behavior. The research findings were presented at Neuroscience 2011, the Society for Neuroscience's annual meeting and the world's largest source of emerging news about brain science health.

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Neurodevelopmental disorders like autism-spectrum disorders and fragile X syndrome are often diagnosed as the brain is developing and a child's difficulty communicating and interacting with others is perceptible. One in every 110 children is diagnosed with an autism-spectrum disorder.

Today's new findings show that:

Children with bipolar disorder look at facial features other than the eyes when determining facial expressions. The findings may explain why they have difficulty identifying emotions, like children with autism (Pilyoung Kim, PhD, abstract 299.10, see attached summary).

An enzyme called STEP is elevated in a mouse study of fragile X syndrome. Removing that protein makes the mice more social, suggesting a new therapeutic target (Susan Goebel-Goody, PhD, abstract 238.02, see attached summary).

The gene that causes fragile X syndrome is associated with brain structure and working memory in healthy men, a finding that may explain why its loss causes disease (Susan Rivera, PhD, abstract 645.08, see attached summary).

"This research is imperative in investigating the causes of neurodevelopmental disorders, which begin early in development and change the trajectory of so many lives," said press conference moderator and child neurologist Emanuel DiCicco-Bloom, MD, of the UMDNJ-Robert Wood Johnson Medical School. "With the help of further research, scientists and clinicians can lay a foundation for effective education, early intervention, and new treatments."

This research was supported by national funding agencies, such as the National Institutes of Health, as well as private and philanthropic organizations.

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