This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade.

Involvement in disease

Pregnancy loss, recurrent, 3

Sequence similarities

Belongs to the annexin family.Contains 4 annexin repeats.

Domain

The [IL]-x-C-x-x-[DE] motif is a proposed target motif for cysteine S-nitrosylation mediated by the iNOS-S100A8/A9 transnitrosylase complex.A pair of annexin repeats may form one binding site for calcium and phospholipid.