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The study was carried out to evaluate the carbohydrate metabolic
enzymes of hexokinase, glucose-6-phosphatase and fructose-1, 6-
phosphatase from streptozotocin induced diabetic animals treated with
chloroform, ethanol, aqueous and ethanol leaf callus extract of
Pergularia daemia. The animals are treated with various concentration
of chloroform, ethanol and aqueous extract are in a dose dependent
manner such as 100 mg/kg, 200 mg/kg and 300 mg/kg and
glibenclamide 600 μg/kg for 21 days. The ethanol leaf callus extract
had significantly higher metabolic effect than leaf ethanol, aqueous and
chloroform extracts. The carbohydrate metabolic enzymes activity of
hexokinase in chloroform leaf extract of P. daemia were 0.055 (μmol glucose
phosphorylated/h/mg protein) and ethanol leaf extract 0.065 and aqueous leaf extract 0.062
and ethanol leaf callus extract were 0.086 and glibenclamide is 0.071. The glucose-6-
phosphatase of various extracts were 0.239 (μmol of phosphorylated/min/mg protein), 0.174,
0.187, 0.161 and 0.205. The fructose-1, 6-phosphatase were 0.480 (μmol of phosphorous
liberated/min/mg of protein), 0.406, 0.427, 0.395 and 0.502 respectively. There was no toxic
changes were observed in leaf extract (100 mg/kg, 200 mg/kg and 300 mg/kg) treated rats
alone. The results obtained in this study indicate that the Pergularia daemia leaf extract can
be a potential source of carbohydrate metabolic enzymes in kidney.