The Susan E. Riley Family Foundation (AWL and POB), The Lustgarten Foundation (AWL), NCI grant CA77097 and HHMI (POB), General Medical Research Service of the Department of Veterans Affairs (SPL). POB is an investigator of the Howard Hughes Medical Institute. The study sponsors had no role in the study design, data collection, analysis, interpretation of the data, writing of the paper, or the decision to submit for publication.