CREAM: Clustering of Genomic Regions Analysis Method

Provides a new method for identification of clusters of genomic
regions within chromosomes. Primarily, it is used for calling clusters of
cis-regulatory elements (COREs). 'CREAM' uses genome-wide maps of genomic regions
in the tissue or cell type of interest, such as those generated from chromatin-based
assays including DNaseI, ATAC or ChIP-Seq. 'CREAM' considers proximity of the elements
within chromosomes of a given sample to identify COREs in the following steps:
1) It identifies window size or the maximum allowed distance between the elements
within each CORE, 2) It identifies number of elements which should be clustered
as a CORE, 3) It calls COREs, 4) It filters the COREs with lowest order which
does not pass the threshold considered in the approach.