Igf-1 long r3 is an 83-amino analog of human IGF-I actually containing the complete human IGF-1 sequence but with the replacement of an Arg for the Glu at position 3, as well as a 13 amino extension peptide at the N-terminus. This makes Long R3 IGF-I significantly more potent ( 2-3x) than IGF-I in studies, because it has a lower affinity to be rendered inactive by IGF binding proteins, and consequently more potential activity in the body.

IGF-1 LR3 is essentially a polypeptide hormone that has the same some of the same molecular properties as insulin, making the compounds fairly similar. IGF does actually stand for insulin-like growth factor, so that gives you an idea of just how alike these substances are. IGF-1's main responsibility is concerned with the long bone growth in children as well as affecting muscle growth and repair of adults.

Long R3 IGF-1 is a more powerful form of IGF-1. It's chemically altered in a specific way in order to prevent the compound from becoming inactive by IGF-1 binding proteins in the bloodstream. This results in IGF-1 LR3 having a longer half-life of 20-30 hours. Before this, it had such a short half-life that it would not be able to be anywhere near as effective as its half-life was only twenty minutes. So that means that a far more effective version was able to be create compared to the short chain that perhaps people were more familiar with.

IGF-1 LR3 is known to be able to provide users with vast improvements when it comes to increasing their muscle mass by inducing a state of muscle hyperplasia, this is basically where there is an increase in the number of new muscle cells being produced in the body. But why is IGF better than HGH? (Human Growth Hormone). One of the main reasons is because HGH causes the IGF levels to rise in the liver first, then the muscle, whereas IGF-LR3 causes the localized levels of IGF to greatly become increased.

Source of active ingredients:IGF-1 plays a significant role in muscle regeneration. Although IGF-1 induces differentiation to a much greater degree, it stimulates both proliferation and differentiation of stem cells in an autocrine-paracrine manner.When IGF-1 is injected locally, it increases satellite cell activity, muscle DNA, muscle protein content, muscle weight and muscle cross sectional area. The importance of IGF-1 lies in the fact that all of its apparent functions act to induce muscle growth with or without overload although it really shines as a growth promoter when combined with physical loading of the muscle.

IGF-1 also acts as an endocrine growth factor having an anabolic effect on distant tissues once released into the blood stream by the liver. IGF-1 possesses the insulin-like property of inhibiting degradation, in addition it stimulates protein synthesis. The insulin-like effects are probably because of the similarity of the signaling pathways between insulin and IGF-1 following ligand binding at the receptors.

The ability of IGF-I to stimulate protein synthesis resembles the action of GH, which was shown in separate studies on volunteers to stimulate protein synthesis without affecting protein degradation. Although it is believed that the effects of GH are mediated through IGF-1, this cannot be the case entirely. First, the effects of the two hormones are different, in that GH does not change protein degradation. Second, the effect of GH is observed with little or no change in systemic IGF-1 concentrations.

Functions:

Increased Amino transport to cells

Increased glucose transport within cells

Increased protein synthesis

Decreased protein degradation

Increased amino absorption

Mobilizes fat for use as energy in adipose tissue

Why is this IGF-1 important for a bodybuilder or athlete? Let's take a look at the list:

Helps regulate fat for use as energy, resulting in fat loss.

Contributes to anti aging. As we get older, IGF-1 production slows down and this results in cell reduction. Low levels of IGF-1 are linked to heart failure, lower brain cell regulation and neuron function. Not to mention muscle tissue breakdown.

IGF-1 LR3 has a half-life of about 20-30 hours and is much more potent than base IGF-1. Since its half-life is about a day, the IGF-1 LR3 will circulate the body, for around 24 hours, binding to receptors and activating cell communication that improves muscle growth and fat loss.

LR3 prevents glucose from entering into cells, which, in turn, forces the body to burn fat and not sucrose. In addition, its long half-life is desirable for another reason; site injections aren't necessary, as IGF-1 LR3 will cycle the body binding to all muscle cells for about a day.