Previous HGNC Symbols for SNORA71E Gene

Summaries for SNORA71E Gene

GeneCards Summary for SNORA71E Gene

SNORA71E (Small Nucleolar RNA, H/ACA Box 71E) is an RNA Gene, and is affiliated with the snoRNA class.

fRNAdb sequence ontologies for SNORA71E Gene
- the ORGUL
cluster for this gene includes several descriptions:

H_ACA_box_snoRNA: Members of the box H/ACA family contain an ACA triplet, exactly 3 nt upstream from the 3' end and an H-box in a hinge region that links two structurally similar functional domains of the molecule. Both boxes are important for snoRNA biosynthesis and function. A few box H/ACA snoRNAs are involved in rRNA processing; most others are known or predicted to participate in selection of uridine nucleosides in rRNA to be converted to pseudouridines. Site selection is mediated by direct base pairing of the snoRNA with rRNA through one or both targeting domains.

Small nucleolar RNA SNORA71: The members of this family belong to the H/ACA class of snoRNAs which bind a number of proteins (including dyskerin, Gar1p and Nop10p) to form snoRNP complexes. This class of snoRNAs are thought to guide the sites of modification of uridines to pseudouridines by forming direct base pairing interactions with substrate RNAs [2]. This family includes U71 (SNORA71), ACA39 (SNORA39) and ACA60 (SNORA60) [1,3]. U71 and ACA60 are predicted to guide the pseudouridylation of U406 and U1004 in 18S rRNA respectively [4]. There is currently no target RNA identified for ACA39 [3].