Kemp Muhl has another musical project she has formed with longtime friend Eden Rice, called "Kemp and Eden."[5] Kemp and Eden have recently been signed up under the independent label River Jones Music.[6] They have an LP, Black Lace Hole, released in 2012.[7] Kemp Muhl has stated on a number of occasions that she uses much of the funds she earns from her lucrative modeling career to fund and produce her music.[8]

In 2017, Charlotte Kemp Muhl founded the band Uni, with vocalist Nico Fuzz and guitarist David Strange.[9] On November 17, 2017, they released their debut 7" single What's the Problem b/w Adult Video.[10] Each song received the music video treatment, both directed by Kemp Muhl. The band's next release is the "Mushroom Cloud" 7", out March 23, 2018.[11]

After meeting at the Coachella Valley Music and Arts Festival,[15] Kemp Muhl has been in a relationship with Sean Lennon since 2006. In an interview, Lennon states he stumbled upon Kemp Muhl's musical talents over a year after they had started dating.[16] Kemp Muhl and Lennon are involved in a number of musical endeavours,[17] and much of their work is written at their own home-based studio in Greenwich Village.