Queen Bee has encountered Earth's heroes, and been bested by them, on a number of ocassions. She battled the original Justice League of America several times early in the group's history, but she was at her most dangerous when she recently worked with Lex Luthor and his Injustice Gang to attempt the ruin of the current JLA. On this occasion, she set up a hive in New York, producing many more drones, but was overcome by her simple inability to detect the color red.