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Everyone is different, and it's totally subjective to the daily dosage (assuming usage is daily). I've known people to be on pretty frequent cocaine usage and just quit one day and bizarrely have zero reaction after, yet I've known people miss their nicotine for half a day and punch the first person they meet.

There isn't always a textbook reaction to drugs.

This. QFT.

The ignorance of some people who speak like they are experts is quite baffling...