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Any successful full-backup using a software that is exchange aware will clear the exchange transaction logs. If the backup fails or isn't a full backup, they won't get cleared. As successful backups are the most important part of any IT setup, it is something that is running regularly anyway and it is the best way to ensure the logs stay small.

If you aren't using an exchange aware backup tool, then first make sure the backups themselves are successful. If they are, you can enable circular logging so that old logs get automatically cleared after they have reached a certain age.

You can change the location to where the logs are saved, but as I don't have an SBS2008 handy, I don't know where exactly that is done.

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If you do regular (daily) backups of the SBS using the SBS backup or other Exchange aware backup program the exchange logs should stay under 50 MB. If you need more space you have other problems that just moving this amount of data will not solve. If you have not already run treesizepro or windirstat to see what is using the space. You must run as administrator to gain access to all the data on the system.