The bank's shares took a 13 percent beating after the news broke and shareholders will likely have more questions for management on how they allowed such a big mistake.

At least one top manager - investment chief Ina Drew - has lost her job and some institutional shareholders are asking that Jamie Dimon be stripped of his dual role of chairman and CEO. So where does the buck really stop? Should the man at the top ultimately be responsible for the actions of his employees?

For now these calls are not that loud because the bank had $19 billion in profits last year. Clearly a $2 billion loss is not going to destroy the institution.

President Obama told the hosts of ABC's "The View" that the bank's risky bets exemplified the need for Wall Street reform.

"JPMorgan is one of the best-managed banks there is. Jamie Dimon, the head of it, is one of the smartest bankers we got and they still lost $2 billion and counting," the president said. "We don't know all the details. It's going to be investigated, but this is why we passed Wall Street reform."

The full interview airs on "The View" Tuesday on ABC at 11 a.m. ET

Todd Hagerman, an analyst with Sterne Agee points out that egregious mistakes were made, but if Dimon were to step down, "who in god's name is going to take his place?"

Before this mess Dimon was widely considered to have a remarkable ability to keep close watch on his more than 250,000 employees. Now it's clear that the Wall Street Journal and Bloomberg News learned about out-of-control trades well before Dimon did.

Dimon is facing criticism in particular because he dismissed the concerns at first, calling the press reports a "tempest in the teapot."

The revelation of the massive loss has led to the bank being downgraded by Fitch, one of the three major financial ratings agencies. The company's stock price is down 13 percent in just two trading days. All developments that surely don't make for happy shareholders.