Radio frequency ablation (BARRX-HALO) uses an electrode mounted either on a balloon or endoscope to deliver heat energy to the diseased lining of the esophagus. A number of studies have demonstrated that BARRX-HALO safely results in a high rate of complete eradication of Barrett’s esophagus, as well as a reduction in the progression of the disease to high-grade dysplasia and cancer. Because of a favorable safety profile, studies have been performed assessing the efficacy of RFA for the earliest stages of Barrett’s, as well as later stages.