PTPIP51 is regulated by its phosphorylation status combined with a thereby induced subcellular redistribution.

The presented data confirms a tyrosine phosphorylation-dependent interaction of PTPIP51 with 14-3-3beta and Raf-1 (显示 RAF1 蛋白) in vivo and a tyrosine-dependent interaction profile with DAGKalpha and PKA.

In glioblastoma PTPIP51 expression increases with the grade of malignancy and PTPIP51 interacts in situ with 14-3-3ss and PTP1B (显示 PTPN1 蛋白).

PTPIP51 might be involved in the regulation of cellular processes associated with differentiation, movement, or cytoskeletal organization

PTPIP51 is a mitochondrial protein (显示 COX6B2 蛋白) with apoptosis-inducing function and that the N-terminal TM domain is required for both the correct targeting of the protein to mitochondria and its apoptotic functions.

PTPIP51 and PTP1B (显示 PTPN1 蛋白), play a role in differentiation and apoptosis of the cytotrophoblast and syncytiotrophoblast, respectively. Moreover, PTPIP51 may also serve as a cellular signaling partner in angiogenesis and vascular remodeling.