The Del Perro Freeway (Interstate 2) is a major freeway that runs through northern Los Santos heading east. It is most likely based on the Santa Monica Freeway in Los Angeles. Its western terminus is at a merging off the Great Ocean Highway (Route 1) in Del Perro and goes east throughout the northern-central section of Los Santos before it later turns southwards and ends at the intersection of the Olympic Freeway (Interstate 4).

The highway never serves less than six lanes in total and is one of the largest highways in the GTA series by max lanes. The highway is eight lanes without lane merges at its greatest.