Do metazoans resolve chiasmata in meiosis I using a separase-dependent mechanism? Yes if you're a nematode (C. elegans), but previous evidence in Xenopus has suggested that perhaps vertebrates resolve chiasmata independently of the Anaphase Promoting Complex/separase pathway. However, this study provides confirmation of the hypothesis that the separase pathway is, in fact, necessary for metazoan resolution of chiasmata.

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