Several of Bessette's works address issues that led to and were representative of the Révolution tranquille, a series of societal shifts that took place in Quebec during the 1960s, which saw increased secularization and a general movement away from the influence of the Catholic Church. His earlier works are written in a realistic style, while his later novels utilize elements of the nouveau roman literary movement and tend to be more experimental. His literary criticism is noted for its Freudian readings of Québécois literature.

One of his most noted works is Le libraire (1960), an existential tale of a book store employee in a small Quebec town in the 1950s. The book deals with one of Bessette's most common themes: the stifling culture of Quebec of that time.