Introduction

The nose is a significant facial feature for the identification of individuals, and it's also considered to be an aesthetic feature because usually, it's the first thing that humans pay our attention to on the face. Furthermore, it plays a significant role in two vital functions; these are the respiration and the olfaction.[1] It is a complicated three – dimensional organ, with a lot of convexities and concavities, due to the distinctive characteristics of the underlying soft tissue, which results in differences in form and appearance.[1][2] Therefore, the nose is a cardinal structure in both the craniofacial reconstruction surgeries and the forensic field.[2]

Structure and Function

The skull bones (frontal, nasal, and maxillae) take part in forming the temple of the nose, and most of its external appearance is made up by the soft tissue structures underlying rather than the bones.[2]

Two paired nasal bones with the ascending process of the maxilla make up the bony vault (upper third) of the nose. The bony vault is smaller in females. At the nasofrontal suture, the nasal bones fuse with the frontal bone; this is called the nasion. The thickness of the bones differs, but it's the thickest at the nasofrontal suture. The average length of the nasal bones is 2.5 cm.[1][3]

The nose is composed of the root, dorsum tip, and columella (the part between nostrils) externally, while the other parts of the nose are composed of the ala, alar sulcus and nostrils. These are all supported by the underlying structures, which are the bones, cartilage, muscles and subcutaneous fat.[1]

The cartilage supports only the nasal bones, ethmoid bones, maxillae, and vomer. The cartilage is composed of the septal cartilage, the bilateral (greater) alar cartilage, the lateral cartilages, the lesser alar cartilage, and the sesamoid cartilage. The nasal septum supports the cartilage itself.[1]

The nasal septum forms the central part of the nose, and it is composed of the vomer posteriorly, and inferiorly it's composed of the ethmoid and the septal cartilage. It supports the soft tissue of the nose and reinforces the nasal structure by splitting it in two.[1][3]

The septal cartilage is connected superiorly to the lateral cartilages and inferiorly to the anterior nasal spine. The lateral cartilages have the shape of a triangle, and they are connected to the septal cartilage, to the inferior part of the nasal bones and sometimes to the frontal process of the maxilla. Both the lateral and septal cartilages disconnect anteriorly to allow movement at the time of respiration.[1]

The lower third of the nose is carried by the lower lateral cartilages that reside on the upper lateral cartilages, thus forming the tip of the nose and contributing to its round shape.[3]

The nasal vestibule represents the entrance of the nose and is padded with squamous epithelium, sebaceous glands, and hair. The squamous epithelium becomes mucosa after nearly 0.5 cm.[3]

Embryology

The maxillary process fuses with the frontonasal process, thus altering the nasal pits into a primeval nasal cavity, through forming a floor for its posterior part and forming the anterior nares altogether. The development of the nasal cavity can be described in four stages[4]:

The first stage: nasal placodes formation

The second stage: nasal placodes convert into nasal grooves

The third stage: the nasal grooves give rise to the nasal pits

The fourth stage: the nasal pits deepen, this is associated with the formation of the posterior nares

Interestingly, nasal trauma is detectable since the fourth month of fetal life. Compression of the nose structures in fetal growth depends on the location of fetus extremities.

Another interesting fact is that nasal septum deviation is already be detectable in fetuses, which enables clinicians to estimate the nasal septum growth and symmetry, and therefore, predict the tendency to dysfunction occurring in the upper respiratory tract.[5]

Blood Supply and Lymphatics

The septum receives vascular supply by a branch of sphenopalatine artery posteriorly, a tributary of anterior ethmoid artery superiorly, a branch of the superior labial artery and the greater palatine artery Antero-inferiorly. The lateral nasal wall gets its supply from the anterior ethmoid artery anteriorly, and the sphenopalatine artery supplies the rest of the structure. The turbinates, which are the lining of the lateral wall of the nose, are extremely vascular, it has large sinusoids, thus forming a system where both shunting of the blood and venous pooling are possible. A branch of the facial artery provides vascular supply to the vestibule.[3]

Nerves

The ophthalmic and maxillary branches of the trigeminal nerve provide the sensory innervation of the external nose. The ophthalmic branch supplies the nose with its three branches, which are the supratrochlear, the infratrochlear and the external nose nerve. The external nose nerve innervates the tip and the posterior part of the nose. The maxillary branch supplies the nose with its two branches, the infraorbital nerve, and the nasopalatine nerve. The infraorbital nerve innervates the tip, the ala and the lateral parts of the nose, while the nasopalatine nerve innervates the nasal septum.[1]

Muscles

There are eight nasal muscles identified; however, only two of these muscles affect the nasal profile - these are the procerus and the nasalis. The procerus muscle has two parts; only the superior medial part covers the nasal bones which inserts to the skin covering the eyebrow and the forehead. The nasalis muscle originates from the maxilla, which is transverse to the dorsum of the nose, and it inserts in the nostrils and the greater alar cartilages. However, the muscles and the soft tissue is not thought to influence the nose contour, but the cartilages do.[2]

Physiologic Variants

One of the vital functions of the nose is to humidify the air before it enters the lungs. Researchers have noted that there are differences in the nose shape among populations, not only because of genetics but also secondary to evolutionary changes of the nose, to adapt to the environment and climate. For example, the width of the nares is highly related to the temperature and absolute humidity, as wider noses are more prevalent in warm and humid climate and vice versa. The alar base width was found to be largest in West Africans and smallest in North Europeans. Both the alar base width and the nares width have progressed among populations because of divergent selection.[6]

Surgical Considerations

Nasal fractures

Nasal fractures are the most common facial fracture in adults, midface blunt trauma is the most common mechanism, and it is usually the result of road traffic accidents, sports injuries, falls, and physical fights. These injuries generally result in ipsilateral nasal bone fracture and contralateral out-fracture with septal deformation.[7] Males are affected more than females, and the most affected age group are in the thirties.[8] Diagnosis is usually made upon clinical evaluation, by history taking and physical examination, while imaging is rarely needed. Common physical findings in nasal fractures include tenderness, crepitus, nasal shortening/depression, step-offs, and nasal base widening. The presence of rhinorrhea may raise the suspicion of cerebrospinal fluid (CSF) leak, and thus the cerebral fluid must be examined, and neurology consulted. Many researchers have described before classification types for nasal fractures; below is the modified Murray classification system which depends on the clinical findings:

The most common complication of nasal bone fractures is nasal deformities. Other complications include septal deviation, nasal obstruction, nasolacrimal duct obstruction with epiphora, diplopia and olfactory disturbances.[9]

If the fracture is simple and noncomminuted, then it is frequently managed by closed reduction.[7] However, 29% of patients report dissatisfaction with this method of management.[9] Open reduction is often necessary for complicated fractures that are associated with soft tissue destruction and loss of nasal support. For bony septal deformities, septal repair and fixation are performed.[7]

Clinical Significance

Nasal bone assessment in prenatal screening

Hypoplasia or absence of the nasal bone is highly associated with Down syndrome. Ultrasound screening for Down syndrome in the first trimester has shown the absence of the nasal bones in 65% of Down syndrome cases, while only 1% in healthy fetuses. Generally, 50% of Down syndrome cases have abnormally short nose root. However, the use of nasal bones as a marker for down syndrome should be done after 11 weeks of gestation, as the nose ossification usually begins at this time.[10]

The absence of the nasal bone is also one of the abnormalities that are detectable during the prenatal ultrasound screening of tetrasomy 9p, which is a very rare chromosomal disorder characterized by the presence of two additional copies of the short arm of chromosome 9.[11]

Nose maldevelopment

Nose maldevelopment can present in many forms; including the isolated absence of the nasal bones, hemi-aplasia, the complete absence of the nose (arrhinia), and others. The effects of these maldevelopments vary from mild aesthetic concerns up to airway obstruction and feeding problems. Establishment of the airway is highly critical in the neonatal period. Later in life, the cases are usually managed individually, and the type of surgical reconstruction done will be based on the type of the deformity. Minor surgeries involving small flaps are often used to correct the defects that are bound only to a small area, while major surgeries with large flaps using bone or cartilage grafts are the choice if the external nose is completely absent.[12]

Nasal deviation

Nasal deviation involves cartilage deviation and, in most cases, bony deviation as well. The etiology may be congenital or due to nasal trauma such as nasal fractures. On the same side of the deviation, the nose is usually shorter, has slanted bone and cartilage sidewalls, while on the contralateral portion, the nose is often longer and has a gradual angularity with the cheeks. As a result, both sides of the nasal airway can be obstructed partially or entirely, which lead to both functional and esthetic problems. To correct this deviation, the nasal bones must be imparted to the midline to straighten it, and this is accomplished by rhinoplasty.[13]

Nasal injuries in sport

The most common nasal injury in sport is epistaxis, followed by lacerations and then fractures. These injuries often happen by the cause of direct blow to the nose in contact sports.[14]

Epistaxis

Epistaxis following nasal trauma can be substantial, however, there is no relationship noted between the severity of the injury and the amount of bleeding.[14] The presence of epistaxis following nasal trauma is highly associated with increased risk of external nasal disfigurement.[15] If there was no other associated injury with the bleeding like a fracture or a laceration, most likely the bleeding will stop spontaneously. Nevertheless, keeping the injured person in sitting position, with head leaning forward, breathing through the mouth and putting an ice bag on the back of the neck to activate the vasoconstriction reflex can also help in stopping the bleeding.[14]

Lacerations

Football helmets or hockey sticks often cause nasal lacerations. They can be associated with fractures, so it is highly important in case of lacerations to palpate the nasal bones to ensure there are no fractures. Lacerations are managed by irrigation and approximation to avoid infection and contamination.[14]

Nasal bone tumors

Nasal tumors are rare, although there are reports of some cases. Osseous hemangiomas are rare benign bone tumors, comprising less than 1% of bone tumors, they mostly involve the vertebra; however, there is a case report of a 16 years old female involving the nose.[16] Moreover, nasal angioma arising from the nasal bones is also a rare benign tumor which has a case report in a 41 years old female. Benign nasal tumors usually undergo management by surgical resection.[17] Ewing sarcoma, which is a malignant bony tumor most commonly affecting the long bones and the pelvis, was also reported to be developed in the nasal bones of a 5 years old female child. Ewing sarcoma treatment is by both chemotherapy and radiotherapy.[18]

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Anatomy, Head and Neck, Nose Bones - Questions

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While conducting a study on aborted fetuses to find out if you could screen the prenatal nasal anomalies, one of the fetuses’ nose is found to be described as “nasal placodes”. Which of the following embryonic stages best describes this physical finding?

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26-years-old male boxer got a hit on his nose while boxing, which resulted in difficulty in breathing, upon examination the provider concluded that the cause of his breathing problems was damage to the cartilages that are involved in the breathing mechanism, what are the cartilages involved?

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You are viewing the CT scan results of a 39 years old female, a victim of a hit and run, you found out that there is a fracture in the area where the nasal bones fuse with the frontal bone. When reporting the results, you will say the patient has a fracture in which of the following?

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Hazra TK,Basu SK,Chowdhury S,Deb P, Haemangioma of the nasal bone. Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India. 2001 Jul; [PubMed]

Vidyasagar MS,Rao S,Fernandes DJ,Ramanujam AS, A rare case of primary Ewings sarcoma of the nasal bone. Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India. 1998 Jan; [PubMed]

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