Summary: Copyright 2004 by the Genetics Society of America
DOI: 10.1534/genetics.104.027524
Selective Phenotyping for Increased Efficiency in Genetic Mapping Studies
Chunfang Jin,* Hong Lan,
Alan D. Attie,
Gary A. Churchill,
Dursun Bulutuglo
and Brian S. Yandell*,§,1
*Department of Statistics, University of Wisconsin, Madison, Wisconsin 53706,
Department of Biochemistry, University of Wisconsin,
Madison, Wisconsin 53706,
The Jackson Laboratory, Bar Harbor, Maine 04609 and §
Department of Horticulture,
University of Wisconsin, Madison, Wisconsin 53706
Manuscript received February 10, 2004
Accepted for publication August 16, 2004
ABSTRACT
The power of a genetic mapping study depends on the heritability of the trait, the number of individuals
included in the analysis, and the genetic dissimilarity among them. In experiments that involve microarrays
or other complex physiological assays, phenotyping can be expensive and time-consuming and may impose