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Interpreting biomarkers and clinical outcome

The use of biomarkers to evaluate coagulation status or anticoagulant effect is controversial at best, as there are few reliable biomarkers that are predictive of outcome. Measuring indirect biomarkers, such as drug levels, is ineffective. Measuring anti-Xa and anti-IIa values, or correction of these values by a reversal agent, is a surrogate marker and needs supplementary data to support its' direct relevance to the clinical event of interest (i.e., correction of bleeding).

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