Normal volunteers without myositis, who will undergo MR imaging to establish normal ranges of MR signal in health muscle

Procedure: Magnetic Resonance Imaging

Other Name: Magnetic Resonance Imaging of the thighs

Detailed Description:

Idiopathic inflammatory myopathies are a heterogeneous group of conditions characterised by skeletal muscle inflammation leading to proximal muscle weakness, often with tenderness, and occasionally dermatological manifestations. Diagnosis is clinical and is based on the Bohan and Peter criteria which comprises clinical examination, serological markers, electromyography (EMG) and muscle biopsy. This has relatively poor sensitivity and specificity. Muscle biopsy in particular has a false negative rate of 10-15% and is invasive. Clinical criteria also lack the discriminatory power to differentiate between recurrent (or breakthrough) myopathy and myopathy secondary to treatment with corticosteroid.

Magnetic resonance (MR) imaging has the advantage of being non-invasive, and is able to discriminate between different tissues, and to identify areas of inflammation. The aim of this study is to assess the effectiveness of MR sequences in the diagnosis of myopathy, monitoring of treatment response, and in differentiating between breakthrough myopathy and steroid-induced myopathy.

Eligibility

Ages Eligible for Study:

18 Years and older (Adult, Senior)

Genders Eligible for Study:

Both

Accepts Healthy Volunteers:

Yes

Sampling Method:

Non-Probability Sample

Study Population

The study group will be patients attendeing rheumatology outpoatient clinics with a suspected diagnosis of myopathy based on clinical criteria

Criteria

Inclusion Criteria:

Any adult patient referred for an MR scan with a suspected clinical diagnosis of myopathy.

Exclusion Criteria:

Patient unable or unwilling to have an MR scan.

Standard MR exclusion criteria will apply.

Contacts and Locations

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study.
To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below.
For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01702870

Locations

United Kingdom

Salford Royal NHS Foundation Trust

Salford, Lancashire, United Kingdom, M6 8HD

George Eliot Hospital NHS Trust

Nuneaton, Warwickshire, United Kingdom, CV10 7DJ

University Hospitals Coventry and Warwickshire NHS Trust

Coventry, West Midlands, United Kingdom, CV2 2DX

Sponsors and Collaborators

University of Warwick

West Midlands Comprehensive Local Research Network

University Hospitals Coventry and Warwickshire NHS Trust

Salford Royal NHS Foundation Trust

The Royal College of Radiologists

Investigators

Study Chair:

Charles Hutchinson, MD FRCR

Professor of Imaging (Radiology), University of Warwick

Principal Investigator:

Terence Jones, MBChB FRCR

Clinical Research fellow in Radiology, University of Warwick

More Information

Responsible Party:

Dr. Terence Jones, Clinical Research Fellow in Radiology, University of Warwick