Eliminating Bottlenecks for Efficient Bioanalysis: Practices and Applications in Drug Discovery and Development

Description

Published October 2014

ISBN: 978-1-909453-88-3

Bioanalysis, commonly defined as the quantitative analysis of drugs, metabolites and biomarkers in biological matrices, is an integral part of various activities within the entire drug discovery and development process. With the well-documented declining return on investment of R&D in the pharmaceutical industry, all areas of discovery and development are increasingly being asked to work individually and collectively to increase efficiency and boost productivity in bringing more innovative medicines to the market with flat, or even decreasing, development costs. The first six chapters of this book describe approaches and technologies to increase the speed and quality of bioanalysis, such as automated method development for sample preparation. Chapters 7–10 deal with some of these regulatory considerations in development bioanalysis. The remaining chapters of this book include a number of current and emerging applications that can have a profound impact on bioanalytical productivity due to their nonroutine nature.