The most prevalent and severe complication of diabetes, the diabetic kidney disease, can be diagnosed much more reliable in a very early stage (3-5 years earlier compared to conventional microalbuminuria test). Furthermore, the method substitutes renal biopsy (puncture of organ) for diagnosis of primary chronic kidney diseases with unsurpassed accuracy and reliability. Analysis of a simple urine sample replaces a two-day hospitalization and avoids biopsy risks such as bleeding, infection or loss of kidney function.