Clinical Genetics of Familial Cancer

Introduction

We are studying the genetic background of the familial clustering of cancer through whole genome sequencing and other techniques. We are interested in finding new genes, investigating the yield of existing detection strategies, and the clinical interpretation of missense and other types of variants that are difficult to classify clinically. Risk figures and clinical strategies are also being studied.

We are involved in a range of national and international studies, many of them focus on Lynch syndrome, the most common type of hereditary colorectal cancer, but also on other types of cancer.