DR ANTHONY MELVIN CRASTO,WorldDrugTracker, helping millions, A 90 % paralysed man in action for you, I am suffering from transverse mylitis and bound to a wheel chair,With death on the horizon, This will not stop me, Gods call only..........DR ANTHONY MELVIN CRASTO Ph.D ( ICT, Mumbai) , INDIA 29Yrs Exp. in the feld of Organic Chemistry,Working for GLENMARK PHARMA at Navi Mumbai, INDIA. Serving chemists around the world. Helping them with websites on Chemistry.Million hits on google, world acclamation from industry, academia, drug authorities for websites, blogs and educational contribution

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Wednesday, 4 March 2015

Christine Le

Toronto organic chemist Christine Le has
developed a more efficient and environmentally friendly method of
manufacturing a potential anti-cancer drug.

Toronto Organic chemist Christine Le has developed a more efficient and
environmentally friendly method of manufacturing a potential anti-cancer
drug.

Christine Le is talking about cooking. It isn’t long before the conversation collides with her other passion: molecules.
She is describing a recent visit to Alinea, the world-renowned
Chicago restaurant that uses a cooking style called molecular gastronomy
to create new flavours and textures in food. The restaurant is known
for using liquid nitrogen and helium in its dishes.
“I thought [the food] was great, but you definitely have to have an open mind to it,” she says.
It is her curious mind that has just earned the University of Toronto PhD candidate a place on Forbes‘ “Top 30 Under 30” list for science. She is the only Canadian on the list, described by Forbes as the “greatest gathering of young game changers, movers and makers.”
The 26-year-old organic chemist is being recognized for discovering
an efficient way to recreate molecules found naturally in plants. Her
discovery could fight cancer at its source by decreasing abnormal cell
growth.
“One reaction she pioneered uses rhodium to speed the production of
eight medicinal compounds, including an anti-cancer drug candidate,” Forbes notes.

James MacDonald for National PostChristine Le in her lab at the University of Toronto campus.

Ms. Le, who worked on this synthesis during her year completing a
master’s degree at U of T, says that while she and her team did not
discover the molecule — named cytosporone B — they developed a way to
create it that reduces the amount of hazardous waste generated in the
production.
“You can’t get a large quantity of these molecules because nature
only produces small amounts. In the lab we try to mimic the compound,”
explains Ms. Le.
The molecule is a naturally occurring compound that is isolated from a
Costa Rican fungus. Previous studies on cytosporone B have shown that
it has the ability to activate a receptor that controls cell death in
live mice.
“When you invent a new reaction you look for a way to shorten the
number of steps it takes to make a molecule of interest. Ideally, you
also want to reduce the amount of waste that you produce. So if you take
fewer steps and use reaction conditions that produce less waste, then
that is best of all,” says Mark Lautens, Ms. Le’s professor and an Order
of Canada recipient for his contributions to organic chemistry.
The molecule can now be made in three steps, saving time, money and
resources. In addition to reducing chemical waste in the manufacturing
process, her method yields the most molecules. “The final step of our
method to create cytosporone B, and related compounds, is completely
‘atom-economical,’ meaning that all the atoms in the starting materials
are conserved in the product and no wasteful by-products are produced,”
says Ms. Le, who was named to Scientific American journal’s “30 under 30” list in 2013.

‘Our motivation lies in what we can
create, but our interest and our passion for chemistry stems from what
we can discover and learn along the way’

In October, Forbes is holding a summit in Philadelphia so
the members of the “30 under 30” list can connect. “It will be great
stepping out of this bubble and meeting people in diverse industries,”
says Ms. Le, adding that she hopes to combine her scientific background
with more business or technology-oriented people.
The daughter of a single mother who works as hairdresser, Ms. Le grew
up in Richmond Hill with two older half-brothers. She realized she had a
passion for science at a young age, ironically through television. Her
favourite shows were Popular Mechanics for Kids, Bill Nye the Science Guy and The Magic School Bus.
Ms. Le says she hopes to inspire the next generation of chemists,
much like her teachers at Cardinal Carter Catholic High School in Aurora
did for her, by tutoring. She is still driven by the same natural
curiosity that her students have.
“I want to understand the world around me on a microscopic level,”
she says. “Our motivation lies in what we can create, but our interest
and our passion for chemistry stems from what we can discover and learn
along the way.”Christine Le
cle@chem.utoronto.ca

Ph.D Student (July 2012)
M.Sc. University of Toronto
B.Sc. University of Western Ontario

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DR ANTHONY MELVIN CRASTO, Born in Mumbai in 1964 and graduated from Mumbai University, Completed his Ph.D from ICT, 1991,Matunga, Mumbai, India, in Organic Chemistry, The thesis topic was Synthesis of Novel Pyrethroid Analogues, Currently he is working with GLENMARK PHARMACEUTICALS LTD, Research Centre as Principal Scientist, Process Research (bulk actives) at Mahape, Navi Mumbai, India.

Prior to joining Glenmark, he has worked with major multinationals like Hoechst Marion Roussel, now Sanofi, Searle India Ltd, now RPG lifesciences, etc. He has worked with notable scientists like Dr K Nagarajan, Dr Ralph Stapel, Prof S Seshadri etc, He did custom synthesis for major multinationals in his career like BASF, Novartis, Sanofi, etc., He has worked in Discovery, Natural products, Bulk drugs, Generics, Intermediates, Fine chemicals, Neutraceuticals, GMP, Scaleups, etc, he is now helping millions, has 9 million plus hits on Google on all Organic chemistry websites. His friends call him worlddrugtracker.

He has good proficiency in Technology transfer, Spectroscopy, Stereochemistry, Synthesis, Polymorphism etc.

He suffered a paralytic stroke/ Acute Transverse mylitis in Dec 2007 and is 90 %Paralysed, He is bound to a wheelchair, this seems to have injected feul in him to help chemists all around the world, he is more active than before and is pushing boundaries, he has 9 million plus hits on Google, 2.5 lakh plus connections on all networking sites, 20 Lakh plus views on dozen plus blogs, He makes himself available to all, contact him on +91 9323115463, email amcrasto@gmail.com, Twitter, @amcrasto

He lives and will die for his family, 90% paralysis cannot kill his soul. Notably he has 9.5 lakh views on New Drug Approvals Blog in 211 countries..................click here

He appreciates the help he gets from one and all, Friends, Family, Glenmark, Readers, Wellwishers, Doctors, Drug authorities, His Contacts, Physiotherapist, etc

OLD BIO

DR ANTHONY MELVIN CRASTO Ph.D , Born in Mumbai in 1964 and graduated from Mumbai University, Completed his PhD from ICT ,1991, Mumbai, India in Organic chemistry, The thesis topic was Synthesis of Novel Pyrethroid Analogues,

Currently he is working with GLENMARKPHARMA LTD, Research centre as Principal Scientist, Process Research (bulk actives) at Mahape, Navi Mumbai, India.

Prior to joining Glenmark, he worked with major multinationals like Hoechst Marion Roussel, now Sanofi Aventis, & Searle India ltd, now RPG lifesciences, etc. He has worked in Basic research, Neutraceuticals, Natural products, Flavors, Fragrances, Pheromones, Vet Drugs, Drugs, formulation, GMP etc. He has total 29 yrs exp in this field, he is now helping millions, has million hits on google on all organic chemistry websites.

He has hands on experience in initiation and developing novel routes for drug molecules and implementation them on commercial scale over a 25 year tenure, good knowledge of IPM, GMP, Regulatory aspects, he has several international drug patents published worldwide .

He suffered a paralytic stroke in dec 2007 and is bound to a wheelchair, this seems to have injected feul in him to help chemists around the world, he is more active than before and is pushing boundaries, he has one lakh connections on all networking sites, He makes himself available to all, contact him on +91 9323115463, amcrasto@gmail.com, Twitter @amcrasto