It will mostly depend on how targeted is your traffic. Do you think your traffic is targeted enought to run CPA offers, or to build a targeted e-mail list? If yes go for it! If not it's always better to run some general PPC income with Adsense.

See if the keywords that are used on the SE for find your site are targeted to a specific keyword or are spread out for multiple keywords you were not thinking in ranking for in the first place.

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