Douglas's Querciplex

Details

DESCRIPTION
Querciplex, provided by Douglas Laboratories, is a
unique formulation of quercetin, magnesium and
bromelain. Quercetin is a bioflavonoid that has
excellent antioxidant activity. Magnesium
synergistically supports the quercetin activity.
Bromelain is a proteolytic enzyme purified from
pineapple, which is active and stable at the acidic
levels found in the stomach.
FUNCTIONS
Quercetin is a naturally occurring bioflavonoid with
strong antioxidant activity. The antioxidant activity
of quercetin protects the gastrointestinal tract in
several ways. First, quercetin prevents oxidation of
lipids. The gastrointestinal tract has an increased
exposure to oxidative stress due in part to the lowered
pH. It is important to protect the lipid bilayer of the
cell wall of the gastrointestinal tract because these
cells serve as an important part of the body’s immune
system.
Secondly, quercetin prevents the depletion of
glutathione from the cells of the intestinal tract.
Glutathione is a cosubstrate for antioxidant enzymes
glutathione peroxidase and glutathione reductase. By
preserving the level of glutathione, quercetin protects
metabolic activity and cellular structure of the highly
vulnerable cells of gastrointestinal tract from toxic
free radical damage. Vitamin C synergistically
improves the ability of the quercetin to preserve
glutathione.
Thirdly, quercetin increases mucus secretion from
gastric cells. The mucus polysaccharide provides a
protective buffer for the gastric cells from the low pH
of the stomach contents. The reduced contact
provides protection from gastric lesions. Quercetin
provides an antispasmodic activity that prevents the
uncontrolled peristaltic activity found in diarrhea.
The reduced excretion of the intestinal contents
provides benefit to the gastrointestinal tract by
preventing the constant production of cellular
protective materials.
Quercetin also reduces the immune response to
allergens. Quercetin inhibits the IgE-mediated
allergic mediator release from mast cells as well as
IgG-mediated histamine release. Quercetin is a
potent inhibitor of the lipoxygenase that metabolizes
arachidonic acid, which is the first step towards
proinflammatory arachidonic acid metabolites.
Thus, quercetin in the gastrointestinal tract helps
protect against gastric lesions that permit highly
antigenic proteins, antigenic compounds and/or
infective agents from passing into the body. In
addition it prevents the release of components of the
allergic inflammation response.
Bromelain is a supportive nutrient in helping prevent
allergens from crossing the gastrointestinal tract.
Bromelain assists in the breakdown of large
macromolecular protein complexes. This reduces the
chance that these complexes will leave the stomach
untouched or in large fractions retaining their
recognizable antigenic form that could pass through
these gastric lesions inducing an allergenic response.
Magnesium plays an essential role in a wide range of
fundamental cellular reactions. More than 300
enzymes require magnesium as a cofactor.
Complexed with ATP, the main carrier of metabolic
energy in the body, magnesium is essential for all
biosynthetic processes, glycolysis, formation of c-
AMP, energy-dependent membrane transport, transmission
of genetic code for protein synthesis, and
muscle function.
INDICATIONS
Querciplex may be a useful dietary supplement for
individuals who wish to supplement their diet with
quercetin, bromelain and magnesium.
FORMULA (#81601)
Each Capsule Contains:
Quercetin .....................................................333 mg
Magnesium (as Magnesium Ascorbate) ........20 mg
Bromelain ....................................................100 mg
SUGGESTED USE
Adults take 1 capsule daily or as directed by
physician.
SIDE EFFECTS
No adverse side effects reported.