Wasteland 2 features a semi-overhead view with a rotatable camera. It will be a turn-based and party-based role-playing game with tactical combat. The player’s party will have room for seven characters, including the four player-designed characters and up to three non-player characters. The player characters will be highly customizable and the player’s choice of statistics, skills and appearance will give them an individualized personality. The non-player characters in the party will each have their own personality, motivations, opinions and agendas.

The game is set in an alternate history timeline, in which a nuclear holocaust took place in 1998 in relation to an impact event involving a cluster of meteors that sparked a global nuclear war. On the day of the cataclysm, a company of U.S. Army Engineers were in the desolate southwestern desert constructing bridges in an area with a number of small survivalist communities and a newly constructed federal death row prison with light industrial facilities. The soldiers sought shelter in the prison, expelled the inmates and invited nearby survivalists to join them shortly thereafter. Years later, together they formed “the Desert Rangers, in the great tradition of the Texas and Arizona Rangers”, to help other survivors in the desert and beyond it.