Abstract

The synthesis of a series of substituted monodonor diazaphospholidine ligands is described. A regioselective lithiation on process is a key step in one of these syntheses. The compounds are designed to be incorporated into soluble polymer and other solid phase supports. Enantiomeric excesses of up to 88% were observed when these compounds were employed in palladium-catalysed asymmetric amination reactions. (C) 2003 Elsevier Ltd. All rights reserved.