And a handshake-proof campaign, can’t lose

ACCEPTED COMMENT: courteys of SILENTWOLF
I think “a handshake-proof campaign” is referencing how he started as a rapper with no intent to sign to a major label (or something like that); in other words no such deals would be made and signified by a handshake. The “cant lose” portion of the line is referencing the fact that since hes not being signed to a major label, hell be able to continue rapping without being dropped as soon as hes not the hottest shit around anymore.