Cortical structures are organized to process information in a parallel manner via excitatory and inhibitory interactions within and between adjacent cortical modules (Mountcastle, 1997). Throughout the CNS, local circuit inhibition plays an integral role in both neuronal network processing and the regulation of the excitability of projection neurons.

Cortical structures are organized to process information in a parallel manner via excitatory and inhibitory interactions within and between adjacent cortical modules [33]. Throughout the CNS, local circuit inhibition plays an integral role in both neuronal network processing and the regulation of the excitability of projection neurons.

[Inhibitory circuits may] be particularly important to signal processing in cortical networks with pronounced recurrent excitatory interactions (Wong et al., 1984). This inhibition may limit the lateral spread of excitation and facilitate discharge synchronization of projection neurons by inducing a synchronous refractory period. Breakdown in the dynamic balance of inhibitory and excitatory interaction can lead to a functional disconnection (Wong and Prince, 1990) and disrupts the normal spread of lateral excitation (Grunze et al., 1996).

Inhibitory circuits may be particularly important to signal processing in cortical networks with pronounced recurrent excitatory interactions [53]. This inhibition may limit the lateral spread of excitation and facilitate discharge synchronization of projection neurons by inducing a synchronous refractory period. Breakdown in the dynamic balance of inhibitory and excitatory interaction can lead to a functional disconnection [52] and disrupts the normal spread of lateral excitation [20].

Simultaneous extracellular field potentials were recorded via two glass microelectrodes (150 mmol/L NaCl; 2 - 10 MΩ) positioned at approximately 5-10 mm intervals across the length of the slice in the third cortical layer (figure 2). The reference electrode and the connection to the microelectrode were symmetric Ag-Ag-KCl bridges. Field potentials were traced by an ink writer and recorded by a digital oscilloscope. Inter-electrode distances were measured with a calibrated eyepiece through the microscope.

Electrophysiological recordings

Simultaneous extracellular field potentials were recorded via four glass microelectrodes (150 mmol/L NaCl; 2 - 10 MΩ) positioned at approximately 2 - 3 mm intervals across the length of the slice in the third cortical layer. [...] The reference electrode and the connection to the microelectrode were symmetric Ag-Ag-KCl bridges. Field potentials were traced by an ink writer and recorded by a digital oscilloscope. Inter-electrode distances were measured with a calibrated eyepiece through the microscope.

Anmerkungen

The source is not mentioned.

In the abstract, on page 5 (8ff), one can read: "Simultaneous field potential recordings of CSD were obtained from four microelectrodes placed 2-3 mm apart across coronal slices in the third layer of the neocortex."