Using suggestions by Ren doing multi layered using Photoshop puppet pin tool since Motion Portrait system is nowhere available for more mortals like me... I was able to imitate the effect I was after... and that is do a motion portrait like micro movements to make a static image more lifelike...

I'm planning on using this and apply it to individual sprites and animate them in Renpy for my upcoming OELVN projects (Aka English Visual Novels)

Now to solve the problem of finding a decent frame-rate that can play on all systems high and low spec.

Again, this is a Mock-Up but the final results will resemble this very VERY closely... probably running at 12 frames per second... probably even lower... I dunno...