Breast Cancer

Introduction

Breast cancer is the largest leading cause of death in women. It is not the primary breast tumor, but the metastases that are responsible for the high incidences of death. Although medical advances have been able to decrease the mortality rate, more and more women are developing breast cancer each year. (1)

HER2/ErbB2: Breast cancer diagnosis

HER2/ErbB2 (human epidermal growth factor) is a protein that can affect the growth of several cancer cells, and its overexpression has been reported in numerous cancers, including breast and ovarian tumors. HER2 is a therapeutic target for the treatment of breast cancer (2) (3).

Related Antibodies

Antibody Name

Cat No

Type

HER2/ErbB2

18299-1-AP

Rabbit Poly

PAX8: Promoting breast cancer proliferation

PAX8 is a member of the paired box (PAX) family, and is involved in oncogenesis. Several recent studies have shown that PAX8 facilitates important regulatory roles in breast cancer cell proliferation and tumor progression. (4) (5).

Related Antibodies

Antibody Name

Cat No

Type

PAX8

10336-1-AP

Rabbit Poly

PAX8-Specific

66073-1-IG

Mouse Mono

Pan-PAX

21383-1-AP

Rabbit Poly

ESR/ER

The estrogen receptor (ESR/ER) is a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. Expression and mutation of ESR/ER are common features in breast cancer. (6) (7).