The topographic isolation (or radius of dominance) of a summit measures how far the summit lies from its nearest point of equal elevation.[5] The third table below ranks the 40 most isolated major summits of Wyoming.

Of the most prominent summits of Wyoming, Cloud Peak and Gannett Peak both exceed 2000 meters (6562 feet) of topographic prominence. Those two peaks and Grand Teton are ultra-prominent summits with more than 1500 meters (4921 feet) of topographic prominence. Nine peaks exceed 1000 meters (3281 feet) of topographic prominence.

^This article defines a significant summit as a summit with at least 100 meters (328.1 feet) of topographic prominence, and a major summit as a summit with at least 500 meters (1640 feet) of topographic prominence. All summits in this article have at least 500 meters of topographic prominence. An ultra-prominent summit is a summit with at least 1500 meters (4921 feet) of topographic prominence.