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Hello. SWIM is a newbie when it comes to heroin, but has experience with all types of opiates. His best friend on the other hand is very experienced, and has only ever shot heroin, had a pretty nasty habit, but is doing well with it recently.
Anyway, I read that Hydroxyzine potentiates opiates, so we decided to take 50-100mg AFTER a heroin dose (and before another one).
Anyway, after about an hour, as the heroin seemed to be wearing down a bit, it would kick back up tremendously, to the point of almost nodding out. SWIMs friend was astounded at this effect, and was quite surprised at how much it seemed to bring back the dope high/potentiate it.
They also smoked weed, which really fucked SWIM up in a good way, he felt VERY blissful, after he thought the heroin high had left him.

Now, SWIM knows taking hydroxyzine about 30-45 mins BEFORE an opiate dose is said to potentiate the effect (up to 2x), but has anyone had experience with taking it AFTER?

It absolutely had an effect, and SWIM would understand if was a placebo for him, esp with smoking weed, but for his friend, who was skeptical about it anyway... god damn!

Anyway, SWIM just got another script for hydroxyzine, so there will be many more tests with it.

Have you heard of any more trials with hydroxyzine & opiates? SIK mentioned this combination, but it sounds like another instance of "take a sleep-inducing medication to increase the nod at the expense of the euphoria" type thing, like benzos. SIK is all for making opiates work better, but making oneself tired isn't the way SIK prefers to do it.

SIK is pretty sensitive to sedating medications like whatever's in Benedryl and promethezine and benzos - .125mg of lorezapam sedates SIK.

Yes, I was prescribed hydroxyzine a few months ago and after they didn't help my anxiety, I threw them aside. I heard about them potentiating opiates so I gave them to a friend who is really experienced with Oxycontin. He has been using Oxy for about six months to a year. He said that it definately made it more intense, maybe even twice the euphoria.

Yeah it is legit. I used to take them for anxiety.
On the package it says one of the uses is to potentate opiates.
Using them with hydrocodone makes the high last a lot longer.
It makes one get more of a bigger body high too

Is the mechanism known?Robo's guessing they don't just increase the nod.

Robo

According to drug information paper by Moscow Scientific Research Institute of First Aid, Hydroxyzine is m-cholino- and h1-histamine antogonist. Both of this properties potentiate opioids/ates, h1-antogonist adds more euphoria then buzz, m-cholino-antogonist mostly potentiate buzz.

From same paper: m-cholino effect starts usual 10-45 mins after taken oraly, depends on form, antihistamine effects starts 1 hour after... For faster effect it is recomended to inject 50-100 mg deep IM. Preanesthetic medication dose 50-200 mg, therapeutic dose... psychiatry dose... bla-bla-bla... Aha! Interaction with other drugs: potentiating... opioid analgetics, BDs... Examples: when taken with Hydroxyzine doses of those drugs should be reduced by 50%: ...codeine, morphine, fentanyl (and long list of opiods)... cos of possibility of heart and breaze stopping... Ketamine dose also should be reduced. Same for phenobarbital, clonazepam (and long list of BDs).

&amp;rew added 41 Minutes and 19 Seconds later...

Preanesthetic medication dose -- recomended dose for anesthesiologists when they use it to potaintiate opioids when prepare patients for surgical interference. Try to turn off junkie with 1g of methadone dose... have to mix a lot of meds.

Post Quality Evaluations:

Very good information, good find.

Last edited by &rew; 04-08-2011 at 15:14.
Reason: Automerged Doublepost

According to drug information paper by Moscow Scientific Research Institute of First Aid, Hydroxyzine is m-cholino- and h1-histamine antogonist. Both of this properties potentiate opioids/ates, h1-antogonist adds more euphoria then buzz, m-cholino-antogonist mostly potentiate buzz.

But if H1 antagonism potentiates opiate euphoria then shouldn't all antihistamines do the same, even second generation antihistamines?

I am curious to this as well. a friend just gave me 25-30 hydroxyzines, and told me to look them up to find out why I'll thank her. She mentioned they were for allergies, somewhat like Benadryl. I tried doing a little research as to how these might be different from other antihistamines, and how they would help my heroin high.

Any more recent scientific and/or personal advice would be sincerely appreciated!