Title (fr)

Publication

Application

Priority

US 29587789 A 19890111

US 37509189 A 19890630

Abstract (en)

A process is described for the total synthesis of the macrolide immunosuppressant, FK-506, and important tricarbonyl process intermediates thereof. The tricarbonyl intermediates can be produced by the mild oxidation of 2,3-dihydroxy carboxylate compounds containing olefin moieties.