Novel Target and New Breast Cancer Drugs for Chemo-Resistant Tumors

Case ID:

2013-014

Web Published:

5/11/2017

Description:

Researchers at AU discovered that Erbin, an ErbB2 interacting protein is necessary for the ErbB2-dependent growth of tumor cells. They prepared small peptides that disrupt the Erbin-ErbB2 interaction, increase ErbB2 degradation, and inhibit growth of tumor cells. Injection of the peptide into tumors in nude mice inhibit tumor growth.