Make your way to Unity Station with Big Smoke. When you get there, some Los Santos Vagos members will hop on the top of the train as it rides off. Quickly, jump on the Sanchez provided for you. Chase the train and ride up next to it and Big Smoke will start to shoot the gang members. Make sure all the gang members are killed before they reach the bridge connecting Los Santos to Flint County. After they are all dead, drive Smoke back to Los Santos and the mission will be complete.

Big Smoke: Hey, you better clear out, CJ. I don't want those C.R.A.S.H. fools trying to pull you into some shit!

CJ: Alright, homie. You be careful with those cats. I'm gonna see you later.

Reward

The reward for this mission is respect, and unlocks the mission Just Business.

Trivia

In the beta, the mission was supposedly to grab a package after the Los Santos Vagos are killed but it was cut before release.

Oddly in the mission Local Liquor Store Carl complains about Catalina shooting so close to his ear, but he doesn't do it to Big Smoke, presumably as he is closer to Big Smoke and the fact that Smoke generally aims the gun higher, limiting the noise.