Abstract

Introduction

Selective
serotonin reuptake inhibitors (SSRIs) are a widely used class of drug
for various psychiatric disorders during the lifespan, including
pregnancy, lactation, childhood, and adolescence. Deterioration in
sexual functioning is a major and serious adverse effect of SSRIs. There
is emerging evidence that SSRIs can have long-lasting effects on
sexuality.

Aim

To summarize
the long-lasting effects of SSRIs on sexuality, starting with animal
models and continuing with the clinical experience of different
investigators.

Method

A literature review of relevant publications in PubMed.

Main Outcome Measures

To assess the long-lasting effects of SSRIs on sexuality.

Results

Although
the persistent effects of SSRIs on sexuality have been little studied
in humans, animal studies suggest that SSRIs might cause permanent
sexual dysfunction after ending SSRI exposure at a young age but not in
adulthood in rats. There are no prospective randomized controlled trials
in humans and the present evidence is derived from case reports,
incidental research findings, and experiences of some internet
communities.

Conclusion

There
is some preclinical evidence from animal studies for enduring
SSRI-induced sexual dysfunction, but the available clinical information
could prevent a clear decision about the existence of post-SSRI sexual
dysfunction, its pathophysiology, and its management. We need more
research to fill in the gaps in our knowledge.