Mass Spectrometry and Hormones

The highly sensitive liquid chromatography mass spectrometry (LCMSMS)-technology is regarded as the gold standard for analytical measurements of small important molecules such as steroid hormones. The LCMSMS methods are based on direct physical measurements of the analytes and are highly specific and sensitive. In contrast to the immunochemical methods, erroneous results due to cross-reactivity and contamination are almost completely eliminated with LCMSMS-technology.

Using in-house developed methods, we can accurately measure a panel of steroid hormones in different materials (serum/plasma, saliva, cell culture media, cell lysate). The methodological platform can thus facilitate a very precise mapping of human steroid metabolism. Moreover, we have automated the sample handling, enabling us to provide high-throughput analyses.

Liquid chromatography–mass spectrometry (LC-MS) is an analytical chemistry technique that combines the physical separation capabilities of liquid chromatography with the mass analysis capabilities of mass spectrometry. Its application is oriented towards the separation, general detection and potential identification of chemicals of particular masses in complex mixtures, such as natural-products extracts and mixtures of chemical intermediates. -Wikipedia