Frazier arrived at Noumea, New Caledonia, 9 December 1942 in
the escort for a group of troop transports. She served on escort and patrol in
the South Pacific for the next 4 months, guarding transports to Guadalcanal,
patrolling off Espiritu Santo, and covering escort carriers as they patrolled
the waters between Efate and the Solomons. On 18 March 1943 Frazier departed
Efate bound for Pearl Harbor and a rendezvous with a task force assigned to
operate in the Aleutians.

After firing in the preinvasion bombardment, Frazier covered
the landings on Attu 11 May 1943, and patrolled off that island and Kiska.
Early in the foggy morning of 10 June, with Lieutenant Commander Elliot M.
Brown in command, she made two separate attacks on radar contacts which were
believed to be submarines. In the second attack, the destroyer's guns fired for
5 minutes as she pursued her target until its radar echo merged with land echo
of Kiska. Late that night and again on the morning of 11 June, Frazier dropped
depth charges on two different underwater contacts, but was unable to determine
the results of these attacks. On 13 June she sighted two periscopes and opened
gunfire on the submarine I-81 who dived quickly but not before Frazier
had scored hits on the periscopes. Immediately gaining sonar contact, the
destroyer began a depth charge attack which brought air bubbles, oil, and
debris to the surface. Two more attacks ensured that the submarine had been
sunk. On 2 and 12 August she fired shore bombardment on Kiska, then covered the
unopposed landings of 15 August. She continued to screen large combatants in
the Aleutians until early September, when she began a brief overhaul at Puget
Sound.

Action bound, Frazier sailed to Wellington, New Zealand, to
join the escort for transports assigned to the Gilbert Islands operation.
Between 7 and 13 November 1943 the group rehearsed at Efate, then sailed on to
Tarawa, where Frazier provided preassault bombardment and call-fire
support to the troops landed 20 November. Patrolling off Betio, on 22 November Frazier
joined Meade (DD-602) in attacking the Japanese submarine I-85. After
the two destroyers had depth-charged I-85 to the surface, they attacked it with
gunfire, and Frazier finally sent her to the bottom by ramming. Her bow
was badly damaged, but none of her men was injured. Two days later she sailed
for repairs and training at Pearl Harbor.

Frazier sortied from Pearl Harbor 22 January 1944 for the
invasion of the Marshalls. She bombarded Taroa and Maloelap on 30 January, and
next screened San Francisco (CA-38) as the cruiser bombarded targets on
Kwajalein, while the landings were made. After patrolling against submarines
off Kwajalein Frazier returned to Pearl Harbor 15 February screening
unladen transports. Between 28 February and 20 March, the destroyer carried out
escort and patrol assignments in the Marshalls, then joined the fast carrier
task force to screen during the air raids on the Palaus, Yap, Ulithi, and
Woleai from 30 March to 1 April.

Returning to Majuro 6 April 1944, Frazier sailed a week later
with a fast carrier task group for attacks on Wakde and Sawar, New Guinea, on
21 and 22 April, in coordination with the landings at Aitape and Hollandia. The
task group also struck at targets in the Carolines as it sailed back to arrive
at Kwajalein 4 May. From 10 May to 27 July, Frazier patrolled the
bypassed Japanese-held islands in the Marshalls, which included Wotje, Jaluit,
and Mille. She bombarded Mille on 26 May, and on 9 June sent her motor
whaleboat in under the guns of Taroa to rescue 10 men, survivors of a flying
boat previously sent in to rescue a downed aviator, and stranded when their
plane was damaged by a shore battery. Two weeks later she rescued two Marine
Corps aviators off Mille.

A west coast overhaul and training at Pearl Harbor preceded Frazier's
assignment to escort duty out of Ulithi between 15 December 1944 and the close
of the year. On 6 January 1945, the destroyer arrived in San Pedro Bay, from
which she sailed the next day for the invasion of Lingayen Gulf. From the day
of the landings, 9 January, until 26 February, Frazier carried out
bombardment, gunfire support, patrol, and escort missions all around Luzon,
taking part in the bombardment of Corregidor on 16 February. After replenishing
at San Pedro Bay, Frazier returned to escort and fire support duties in
the Manila area, covered the landings at Mindanao in mid-March, and patrolled
against submarines between Lingayen Gulf and Subic Bay on 10 May.

Sailing from San Pedro Bay 13 May 1945, Frazier arrived at
Morotai 2 days later, and based here for the Borneo operation. She took part in
the invasions of Brunei Bay and Balikpapan, and escorted support convoys to the
assault areas until returning to Subic Bay 29 July for training. Assigned to
the Philippine Sea Frontier for escort duty at the close of the war, she made
voyages to Okinawa and Japan until 3 November, when she sailed for Boston and
Charleston, SC. There Frazier was decommissioned and placed in reserve
15 April 1946.