The urban surface runoff pollution is a very complicated process of multimedia, spatiotemporal multidimensional and multi-pollutants. On the basis of monitored pollutant loads of urban surface runoff at a catchment in Futian River watershed in Shenzhen City of China, a regression model of pollutant loads of urban surface runoff with rainfall physical parameters was established, in which the rainfall parameters include rainfall depth (h), average intensity (I), antecedent dry period (D), event duration (T), maximum instantaneous intensity (IMAX) and maximum 5 minutes average intensity (I5min). In the study area, the variable found to be most significant in the prediction of the pollutant load for COD, SS, TN and TP was the rainfall depth. Other rainfall parameters have different contribution to the pollutant loads.