Activity of BC-3205 when tested against Gram-positive organisms responsible from skin and skin structure infections

Abstract number: P911

Objective: To assess the in vitro activity for BC-3205, a novel semi-synthetic pleuromutilin, against a contemporary collection of Gram-positive cocci. Pleuromutilins inhibit bacterial protein synthesis by binding to the 50S ribosomal subunit. BC-3205 is in early stage clinical development for oral treatment of multidrug-resistant (R) skin and skin structure infections (SSSI).

Conclusions: BC-3205 was very active against a representative collection of contemporary pathogens associated with SSSI. Pending further pharmacokinetic/pharmacodynamic and early clinical trial studies, BC-3205 appears to be a promising treatment for cutaneous infections caused by R Gram-positive organisms.