-unknown but not a CNS depressant
-slow response = 2-4 weeks
-extensive first pass effect
-no abuse potential
-aims at a certain receptor site
-disadvantage: take a long time for the appropriate therapeutic level.

What are the Adverse Effects of Buspirone ( Buspar)?

-dizziness
-nausea
-nervousness
-dysphoria, spacey feeling

Anti-anxiety Drugs

What are the drug interaction of Buspirone ( Buspar)?

-Erythromycin (anti-biotic)
-Ketoconazole (anti-fungal)
-grapefruit

Anti-anxiety Drugs

Anti-Histamines

What is the MOA of
HYDROYXINE (Vistaril, Atarax)?

-Blocks the histamine receptors which, blocks the histamine effect, works good with allergies
-depression of the CNS
-sedation

Anti-Histamines

When do you used this med
HYDROYXINE (Vistaril, Atarax)?

IND:
*Pain relief
*Anxiety
*Sedation

*Anti-Depressants*

What is the MOA?
SSRI's
(Selective Sertonin Reuptake inhibitors)

FLUOXETINE (Prozac)

-acts to inhibit the re-uptake of serotonin. the serotonin stays in the gap.
-may also act on norepinephrine and dopamine
-some have multiple receptor actions; others very specific receptor action
-results in INC concentrations of Neurotransmitters at nerve endings in the CNS.

WHEN DO you use Prozac?

IND:
-Depression
-Anxiety
-Bulimia
-Alcoholism
-Migraines
-etc.

Selective Sertonin Reuptake inhibitors)

What are the adverse effects for SSRI's FLUXETINE (Prozac)?

AE:
-Very safe and well tolerated
-Nausea and vomitting
-sexual dysfunction
-INC suicide risk (w-young children and young adults)
-Serotonin Syndrome
-Withdrawal syndrome-Taper it off
-neonatal withdrawal- if the mother's been on prozac

MOA:
*suppress inflammation in airways, leads to a DEC in Bronchial hyperactivity.
*DEC synthesis and release of anti-inflammatory mediators
*Dec Mucus production and INC number and sensitivity of beta 2 receptors