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"There's always a syndicate behind it, particularly where you see products coming from other countries," Mr Fontana also told reporters in Melbourne on Friday.

"I'm sure they won't be happy about losing their product - that's profit that they have lost but they will probably be determined to keep moving on.

"We've got a glut of drugs out there, that's the reality ... but we're not going to give up on it."

The Melbourne operations followed major drug seizures in Queensland and Tasmania in recent days.

"In the past week alone law enforcement agencies have seized more than 220kg of illicit drugs and more than $2 million in cash," Australian Crime Commission national manager of investigations Richard Grant said.

"This is great news for the community as these drugs will not reach the streets and the money will not be sent offshore."