I have not taken those two products, but you might want to taper slowly off Cymbalta and try L-tryptophan instead. Do NOT start it until you are off Cymbalta, or you could develop serotonin syndrome which is dangerous. Once off the SSRI, begin with 500 mgs. L-tryptophan at bedtime and increase slowly until you get relief. I take 1.5 grams at bed time, and another 1 gram at 3 am.

I don't know of a substitute for Lyrica off hand...it would depend upon what you are taking the Lyrica for.