Target details

Target details

CCAAT/enhancer-binding proteins (C/EBP) consist of a family of transcription factors that play an important role in regulating the balance between cell growth & differentiation. The various isoforms of C/EBP (α,,Beta,γ,,δ,,ε,, ζ, ) exhibit similar DNA-binding specificities and contain a leucine zipper dimerization domain (1). A number of serine targets of PKA have been identified in C/EBP-Beta, suggesting its activities are post-translationally regulated by cAMP (2). Even though, it has been show that C/EBP Beta occurs predominantly as a heterodimer (3), C/EBP Beta & γ, readily heterodimerize with each other as well as with C/EBP α, (4). Additionally, 3 isoforms of C /EBP Beta can be detected (LAP*, LAP, & LIP) (5).Synonyms: Cebpb, Crp2, Sfb, CCAAT/enhancer-binding protein beta, C/EBP-related protein 2

Application Details

Application Details

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Application Notes

The suggested dilution is: WB: = 1:500-1000

Comment

Background: CCAAT/enhancer-binding proteins (C/EBP) consist of a family of transcription factors that play an important role in regulating the balance between cell growth & differentiation. The various isoforms of C/EBP (α,,β,,γ,,δ,,ε,, ζ, ) exhibit similar DNA-binding specificities and contain a leucine zipper dimerization domain (1). A number of serine targets of PKA have been identified in C/EBP-β,, suggesting its activities are post-translationally regulated by cAMP (2). Even though, it has been show that C/EBP β, occurs predominantly as a heterodimer (3), C/EBP β, & γ, readily heterodimerize with each other as well as with C/EBP α, (4). Additionally, 3 isoforms of C /EBP β, can be detected (LAP*, LAP, & LIP) (5).