The river is implied by the documentary "A History of Liberty City" to be heavily polluted before even the establishment of the city itself, due to the natives using it effectively as a sewer.

There are two Stunt Jumps on the river, one near Hatton Gardens and one near Colony Island. You have to use a boat for both of the jumps.

Trivia

Its real life counterpart is the real life Hudson River, as the main and bigger river in New York. Its location is based on the East River. It is not influenced by the real Humboldt River that runs through northern Nevada.

The game makes many references to murderers and serial killers hiding the bodies of people they have killed, or want to kill, in this certain river.