Susan and Frank spent hundreds of hours fundraising for their non profit foundation, FAME (Foundation for African Medicine and Education), searching out locations for their clinic, and learning the in's and out's of medical care in Africa.

None of them would speak to you, not even when you showed the whole wide world the in's and out's of zippers in Home Ec. You found me weeping in my Corvair once and pulled a tissue from your bag for me and said the wisest, kindest things

A volunteer may have an interest in animal shelters and be skilled in marketing, but without fully understanding the in's and out's of your shelter, she may not be able to come up with relevant ideas to promote your work.

Under the tutelage of U. S.-born Anwar al-Awlaki -- the so-called "Bin Laden of the Internet," Al Qaeda has successfully transformed southern Yemen into a base of operations, where al-Awlaki has inspired scores of jihadi recruits to plot, plan, and train other recruits in the in's and out's of navigating America's homeland defenses.