According to Manta.com, there are 46,999 businesses in Knoxville TN as of January 2016.

Mom and Pop Businesses: KnoxvilleKnoxville is blessed with many mom and pop businesses, the lifeblood of America. Check out the Mom & Pops

Most businesses within Knox County must obtain a business license. Those businesses located within the municipal boundaries of the City of Knoxville must also register with the City of Knoxville Department of Finance.

From their start date, new businesses have a 20 day grace period to obtain a license. To apply, you may either complete the online application at the link above, or download an Application for Business Tax License. Mail the completed application along with the fee of $15.00 payable to "Knox County Clerk" to:

Downtown KnoxvilleDowntown Knoxville is also a place where business gets done in East Tennessee. With nearly 6.2 million square feet of downtown office space, it's the home to many of the region's top corporate leaders, as well as hundreds of service, entertainment, retail, financial and professional businesses.www.downtownknoxville.org