Video-Assisted Surgery Followed by Radiation Therapy in Treating Patients With Stage I Non-small Cell Lung Cancer and Poor Heart and Lung Function

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RATIONALE: Video-assisted surgery followed by radiation therapy may be an effective treatment in patients whose poor heart and lung function make them high risk for standard surgery.

PURPOSE: Phase II trial to study the effectiveness of video-assisted surgery followed by radiation therapy in treating patients with stage I non-small cell lung cancer and poor heart and lung function.

Determine the feasibility of video-assisted thoracoscopic wedge resection (VAR) followed by radiotherapy in patients with stage I non-small cell lung cancer and cardiopulmonary dysfunction.

Determine the incidence of locoregional recurrence in patients treated with this regimen.

Determine the overall and disease-free survival in patients treated with this regimen.

Determine the technical feasibility of ipsilateral lymph node sampling and complete resection with VAR in these patients.

Determine the incidence of conversion to open thoracotomy in these patients.

Determine the short- and long-term complications associated with VAR in these patients.

Determine the toxicity of adjuvant radiotherapy after VAR in these patients.

OUTLINE: This is a multicenter study.

Patients undergo video-assisted thoracoscopic wedge resection. Surgeons attempt sampling and identification of all ipsilateral, mediastinal, and hilar lymph nodes. When accessible, lobar lymph nodes must also be sampled. If the tumor margins are positive, further resection of the margins must be attempted. Open thoracotomy may be required for technical reasons.

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Ages Eligible for Study:

18 Years and older (Adult, Senior)

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

No

Criteria

DISEASE CHARACTERISTICS:

Known or suspected, single, peripheral, stage T1 N0 M0 lung tumor

Tumor must not be identifiable by bronchoscopy

Bronchoscopically visible cancer or bronchial distortions considered related to tumor

Positive cytology by bronchoscopy allowed if no gross abnormality visible

Mediastinoscopy required for nodes greater than 1 cm

No pleural effusions

No metastatic or N2 disease on CT scan

Lesion must be accessible for video-assisted thoracoscopic wedge resection

High cardiopulmonary risk for thoracotomy with at least 1 of the following criteria:

FEV1 less than 40% predicted

DLCO less than 50% predicted

Supplemental oxygen requirement

Chronic PaCO2 greater than 45 mm Hg

Maximum oxygen consumption (VO2 max) less than 15 mL/kg/min

Patients who appear at high risk for non-pulmonary reasons (e.g., patients who are elderly or with renal or cardiac failure) may be eligible only if VO2 max or other criteria above are met

Eligible for radiotherapy after completion of wedge resection if histologic documentation of non-small cell lung cancer, including any of the following subtypes:

Squamous cell carcinoma

Adenocarcinoma

Bronchoalveolar cell

Large cell anaplastic carcinoma

Cytology from bronchial washings and transthoracic needle aspiration not acceptable

PATIENT CHARACTERISTICS:

Age:

18 and over

Performance status:

0-2

Other:

No other malignancy within the past 5 years except nonmelanomatous skin cancer or carcinoma in situ of the cervix