Footnotes

1. To learn more about our methods, data sources, and analysis, please see our in-depth publication in BMJ Open. Our data is all publicly available at Drugs@FDA, www.clinicaltrials.gov, and through PubMed and Google Scholar searches.
2. See Appendix for a list of the active ingredients for each of our analyzed drugs.
3. This is the number of trials we analyzed from the 2012 FDA approval packages for these drugs.
4. We defined trial results as publicly available if they were either published in the medical literature or reported in a public registry.