Dr. Michael Murray ND states that clinical studies have shown PharmaGABA to produce significant relaxation and anti-stress effects, including changes in brain-wave patterns, pupil diameter, heart rate and salivary cortisol levels. The effects of PharmaGABA feel different to me than with regular GABA. The PharmaGABA seems to affect a broader area of the brain and for a longer period of time, as opposed to regular GABA which seems limited in its effects and its duration. I take one capsule at bed to help with sleep.