Datasheet Extract

A synthetic pentamer-peptide from the n-terminal part of rat, mouse, human, rabbit, sheep ancient ubiquitous protein 1 conjugated to an immunogenic carrier protein was used as the immunogen.

Add. information

Reconstitute in 0.15 ml of sterile water. Centrifuge to remove any insoluble material. When reconstituting, glycerol (1:1) may be added for an additional stability.

Application

immunohistochemistry, Western Blot, Immunohistochemistry and Western Blot., immunohistochemistry, Western Blot 1:1000-1:8000

Background

This gene encodes a protein that contains a domain with homology to the ancient conserved region of the archain 1 gene and a domain that may be involved in binding ubiquitin-conjugating enzymes. The protein encoded by this gene has been shown to bind to the conserved membrane-proximal sequence of the cytoplasmic tail of integrin alpha(IIb) subunits. These subunits play a crucial role in the integrin alpha(IIb)beta(3) inside-out signaling in platelets and megakaryocytes that leads to platelet aggregation and thrombus formation. This gene overlaps the gene for mitochondrial serine protease 25.

Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.