Properties: Migracid tablets is one of the most effective therapy for the management of migraine. It combines analgesic (paracetamol) and antiemetic (metoclopramide) properties. The paracetamol and metoclopramide are claimed to reduce the frequency and severity of headache and assist in allaying nausea and vomiting that often accompany a migraine attack . Clinical experience and some comparative trials indicated that the mixture gives greater relief of symptoms than the components given separately . Metoclopramide which probably acts as antiemetic is reported to increase absorption of paracetamol .

Indications & usage : Migraine.

Contra-indications: - Do not use in situation where stimulation of gastro-intestinal motility might be dangerous. - Contraindicated in patients with pheochromocytoma. - Sensitivity or intolerance to its components .

Drug interactions : - Migracid has been suggested that it should not be given to patients receiving MAOIs . - Caution should be observed when using metoclopramide in patients taking other drugs that can also cause extra pyramidal reactions , such as the phenothiazines . - Metoclopramide may diminish absorption of digoxin from stomach and so decreases the therapeutic effect of digoxin . Metoclopramide may increases prolactin blood concentrations and

therefore interferes with drugs which have a hypoprolactinaemic effect such as bromocriptine . - Concurrent use of paracetamol with anticoagulant , anti-inflammatory drugs and CNS stimulants are not recommended .