Vanishing bone disease (VBD) is an uncommon clinical entity with unknown etiology. This disease affects individual irrespective of age or sex. It can affect any bone of the body including the mandibular region of the face. The osseous tissue is progressively replaced by angiomatic tissue and finally by fibrous tissue. It is usually seen in the second and third decades of the life. It is often difficult to diagnose and the treatment is controversial. Here, we report a case of aggressive VBD in the mandibular region which was treated with radiotherapy and zoledronic acid. Because of its rarity, we described this clinical scenario affecting cosmesis of the patient with pain in face-and-neck area.