Clinton was a member of the Democratic-Republican Party. Clinton was vice president under two different presidents. He is one out of two vice presidents who did this; John C. Calhoun served under two presidents as well. Clinton was also a candidate for president in the 1808 election and did receive six electoral votes.

DeWitt Clinton, his nephew, also became governor of New York. George Clinton has no known relation of 42nd PresidentBill Clinton, who took his stepfather's surname as a child.