Multiple myeloma is the second most common type of blood cancer, killing 20% of affected patients each year. The drug thalidomide, banned after causing birth defects when given during pregnancy in the 1950s, was recently rediscovered and approved for the treatment of multiple myeloma. Thalidomide works by disturbing the microenvironment of tumour cells in bone marrow. However, it disintegrates in the body. Curcumin, a yellow pigment from the common spice turmeric, is also active against cancers, including myeloma, but is limited by its poor water solubility.

Shijun Zhang at Virginia Commonwealth University, US, and colleagues, have synthesised compounds combining structural features from both thalidomide and curcumin. The hybrids have enhanced solubility, and higher toxicity against myeloma cells than curcumin, thalidomide, or a mixture of both, explains Zhang, so our design rational is going in the right direction. Zhang says the hybrids kill myeloma cells through combined mechanisms of action that include the generation of reactive oxygen species and cell cycle inhibition.

The advantage of the hybrid compounds is that they are stabilised, and do not degrade in the body as thalidomide does, says William Douglas Figg from the National Cancer Institute in Bethesda, US, who has conducted numerous studies and clinical trials with thalidomide derivatives. However, from his experience, compounds considered for further trials should be more toxic to myeloma cells.

In the meantime, one of Zhangs hybrid compounds has shown activity against myeloma and prostate cancer in animal models.

Another one is Boswellia Serrata Frankensence to Bible-reading folks.

Yep! The stuff is awesome. Thanks for the link. We have purchased the essential oil from Young Living or Rocky Mountain Oils (little cheaper from RM, but not sure if the same quality). The stuff from YL has stopped fits of rage in seconds flat. Never seen anything like it!

13
posted on 07/02/2013 8:46:20 PM PDT
by mlizzy
(If people spent an hour a week in Eucharistic adoration, abortion would be ended. --Mother Teresa)

There are two forms of thalidomide, a left handed chiral and a right handed chiral. One is safe, the other is the one that causes birth defects. Why they simply didn’t allow the one form that didn’t cause birth defects to remain the one to prescribe is kind of an over-reaction.

I always wondered about turmeric. Everyone in my Grandparent’s generation (in my family) lived well into their 90’s. All of them were raised on farms; all of them canned and pickled everything.

I spent quite a bit of time thinking about what they “ate” that might have been significantly different than our usual daily diet. Aside from the obvious fact that the food was not generally highly processed...I came up with “pickled things” most of which contained Turmeric; and cottage cheese...both of which were served at nearly every meal.

Hadn't heard of taking it with coconut oil (thanks!), but take it daily with black pepper. I use an extract from Natural News

I take my tumeric as well as capsicum with two tablespoons of coconut oil. I'm keto adapted, so the coconut oil is like pouring gasoline into a fire and I can feel the cardio nutrition from the capsicum within seconds.

28
posted on 07/03/2013 3:31:24 AM PDT
by RobertClark
(My shrink just killed himself - he blamed me in his note!)

Depending on the brand (I buy mine from my naturopath - it doesn’t smell or taste like coconut), I can either drink it straight or I put it in my coffee.

I just wanted to throw out some other supplements that have anti-cancer properties to them: Vitamin D, Selenium, ALA, Iodine & Magnesium. In addition to these, Green Tea Extract and Resveratrol Grape Seed & Red Wine Extracts.

41
posted on 07/03/2013 8:14:32 AM PDT
by diamond6
(Behold this Heart which has so loved men!" Jesus to St. Margaret Mary)

I take one capsule of Turmeric daily (about 550 mg) for cancer prevention, primarily skin cancer. I have read that it can help. Should I take more than that?

OK the short answer is that I think u should take TWO, not one, and here is the more important thing:

Take those along with your fattiest meal of the day --for most folks that's dinner. Lessay you eat a bunch of lasagna? Yeah, take it with that.

Or lessay you eat a huge omlette with plenty of butter --take it then.

Whatever you eat that is super fatty --and I know you eat fats-- you take your curcumin (tumeric, but the active component) THEN.

While it's super cheap and super therapeutic it's bioavailability is pretty low --just cuz it gets past your lips does not at all mean that it is getting uptaken.

Also it does not circulate for a long time --all the expensive efforts to ligate curcumin to other bigger things have the objective of making it patentable ($$$) and maybe also get it to circulate for a longer time b4 being eliminated.

I really think the best --for years-- will be to consistently take pure curcumin with something fatty and peppery.

And you should try the frankensense/gum thing I described --it's cheap, simple, reliable, and highly thereapeutic.

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