I am trying to configure Office 2016 to connect to Exchange 2010 remotely. I enter all the configuration settings and it is recognizing the server I am entering, but saying the username or password is wrong, which it is not. Any suggestions would be greatly appreciated.

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Check Credential Manager to see if any credentials are cached. Control Panel > Credential Manager > Windows Credentials. Expand any entry that says MicrosoftOffice16 and select Remove. Then try to connect Outlook to Exchange.

JoeDaddy...I have tried all variations of the usernames. domainname\username, domainname/username, username@domain.com, domainname.com\username and just the username. I have no problems connecting Outlook 2010 remotely, but this Outlook 2016 is giving me fits. I have tried both my personal credentials and the admin credentials as a gut check.