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Conventional wisdom holds that the fastest swimming sperm
are most likely to succeed in their quest to fertilize eggs.That wisdom was turned upside down in a new
study of sperm competition in fruit flies.

When it comes to sperm meeting eggs in sexual reproduction, conventional wisdom holds that the fastest swimming sperm are most likely to succeed in their quest to fertilize eggs. That wisdom was turned upside down in a new study of sperm competition in fruit flies (Drosophila melanogaster), which found that slower and/or longer sperm outcompete their faster rivals.

The study by Syracuse University scientists, recently published online in Current Biology and forthcoming in print on Sept. 25, was done by a team of scientists led by corresponding author Stefan Lüpold, a post-doctoral researcher in the Department of Biology in the College of Arts and Sciences, and a Swiss National Science Foundation Fellow working in the laboratory of biology Professor Scott Pitnick..

The team made the discovery using fruit flies that were genetically altered so that the heads of their sperm glow fluorescent green or red under the microscope. The fruit flies, developed by biology Professor John Belote, enable researchers to observe sperm in real time inside the female reproductive tract.

Lüpold: "Sperm competition is a fundamental biological process throughout the animal kingdom, yet we know very little about how ejaculate traits determine which males win contests. This is the first study that actually measures sperm quality under competitive conditions inside the female, allowing us to distinguish the traits that are important in each of the reproductive phases."

The research is also significant because the scientists studied naturally occurring variations in sperm traits, rather than manipulating the test populations for specific traits. After identifying and isolating groups of males with similar ejaculate traits that remained constant across multiple generations, the scientists mated single females with pairs of males from the different groups.

Lüpold: "This approach allowed us to simultaneously investigate multiple ejaculate traits and also observe how sperm from one male change behavior depending upon that of rival sperm."

Female fruit flies mate about every three days. Sperm from each mating swim through the female bursa into a storage area waiting until eggs are released - while eggs travel from the ovaries into the bursa to await meeting the sperm. However, sperm battles actually take place within the storage area.

After each mating, new sperm try to toss sperm
from previous matings out of storage.
The female then ejects the displaced sperm
from her reproductive system,
eliminating them from the mating game.

Researchers observed that longer and slower-moving
sperm were better at displacing their rivals
and were also less likely to be ejected from storage
than their more agile counterparts.

Lüpold: "The finding that longer sperm were more successful is consistent with earlier studies. However, the finding that slower sperm also have an advantage is counterintuitive."

Why slower sperm have an advantage is still open to speculation.

Lüpold: "It could be that, when swimming back and forth in storage, slower sperm hit the exit less frequently and are therefore less likely to be pushed out. Or, because sperm velocity is dependent on the density of sperm within the narrow storage area, it could be that velocity isn't really the target of sexual selection in fruit flies, but is rather a consequence of the amount of sperm packed into the storage organ."

The U.S. National Science Foundation (NSF) and the Swiss National Science Foundation funded the study.

Original article: http://www.eurekalert.org/pub_releases/2012-08/su-nsb080112.php