Conventional methods of stenting require predilatation, which potentially increase vessel wall injury and cost of the procedure. In this study, the safety and efficacy of direct AVE-S7 (Medtronic-USA) stent placement were evaluated in 100 patients. Quantitative coronary angiography was performed at the baseline and post-stent. Clinical follow-up was done up to 9 months. In 100 patients (76 male/24 female; mean age 51±12 years), with stable angina (n=84; 84%) and unstable angina (n=16; 16%), 102 AVE-S7 stents (diameter 3.2 ± 0.2 mm) were implanted for 102 stenoses. Direct stenting was successful in all stenoses. No stent was lost or damaged and all stents were implanted at the target site. Angiographic success (<30%residual stenosis) was achieved in all lesions. In the 9-month follow up, none of the patients died. Target lesion revascularization became necessary in 8(8%) patients after 3 months and in 4 (4%) other patients after 6 months. After 6 months, 78 patients (78%) and after 9 months 82 patients (82%) were free of anginal symptoms and after 9 months 80% of the patients were free of the ischemic events. This study demonstrates the safety and efficacy of direct placement of the AVE-S7 stent as well as its favorable clinical and angiographic results up to the 9 months after the procedure