This meeting took place in 2018

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DNA and RNA Methylation (A7)

Organizer(s) Chuan He and Ting Wang

January 21—25, 2018

Fairmont Hotel Vancouver • Vancouver, BC Canada

Discounted Abstract Deadline: Sep 27, 2017

Abstract Deadline: Oct 27, 2017

Scholarship Deadline: Sep 27, 2017

Discounted Registration Deadline: Nov 28, 2017

Sponsored by Cell Research

Summary of Meeting:The eukaryotic genome and transcriptome are not merely a static combination of A, T, C, G and U. Reversible DNA methylation is known to contribute significantly to gene expression regulation. In recent years, dynamic RNA methylation has also emerged as a major mode of post-transcriptional regulation of gene expression. DNA and RNA methylation is a field which is revolutionizing our knowledge on how the human genome functions, how cellular and environmental signals and stresses impact gene expression through DNA and RNA methylation, and how these inform our understanding of human disease mechanisms. This conference brings together an international group of scientists to present and discuss the emergence of and new developments in epigenomics/epitranscriptomics and their impacts on basic biology as well as human diseases, with a focus on DNA and RNA methylation. In addition, the conference provides hands-on workshops for junior and established scientists on key sequencing and computational methodologies and resources for epigenomics/epitranscriptomics research. These components will ultimately catalyze DNA and RNA methylation research and accelerate the pace of discovery. The conference will advance knowledge in the field by bringing together scientists who apply epigenomics/epitranscriptomics research to understand basic biology and human disease, thus catalyzing adoption of epigenomic/epitranscriptomic methods. Finally, it will foster scientific interactions that will ultimately accelerate the pace of discovery across multiple basic and disease-focused research areas.

The meeting will begin on Sunday, January 21 with
registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00.
Conference events conclude on Thursday, January 25 with a
closing plenary session from 17:00 to 19:00,
followed by a social hour and entertainment. We recommend return travel
on Friday, January 26 in order to fully experience the meeting.

Advances in next-generation sequencing technology have reshaped the landscape of genomic and epigenomic research as well as human genetics studies. Annotating the non-coding, regulatory genome with genomic and epigenomic data has provided new venues to interpret the functional consequences of genetic variants associated with human complex traits. Large consortiums such as ENCODE and Roadmap Epigenomics project have generated tens of thousands sequencing-based genome-wide datasets, creating a reference and resource for the scientific community. There is a great need for investigators to effectively engage with this resource in the context of analyzing investigators’ own data. This interactive workshop will introduce The WashU Human Epigenome Browser and associated tools (http://epigenomegateway.wustl.edu/). The WashU Epigenome Browser hosts data from ENCODE, Roadmap Epigenomics, IHEC as well as 4D Nucleome Consortia, and supports navigation of the data and its interactive visualization, integration, comparison, and analysis. Attendees will gain hands-on experience with exploring the most current epigenomic and 3D chromatin structure resources, and with advanced visual-bioinformatics tools including gene set view, genome juxtaposition, and chromatin-interaction display, inventions unique to the WashU Epigenome Browser. Through specific examples the workshop will demonstrate the power of annotating genetic variants with epigenomic data, and how it can be easily achieved with the Epigenome Browser.

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

If your organization is interested in joining these entities in support of Keystone
Symposia, please contact:&nbspSarah Lavicka,
Director of Corporate Relations, Email: sarahl@keystonesymposia.org,Phone:+1 970-262-2690

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