The International Society of Sports Nutrition recently concluded, “There is no compelling scientific evidence that the short- or long-term use of creatine monohydrate has any detrimental effects” (1).

Studies have reported that consuming monohydrate for two to five years appears to be safe, with no adverse effects documented (2, 34).

This supplement appears to be safe at higher doses, too. Although a typical daily dose is 3–5 grams, people have taken doses of up to 30 grams per day for up to five years with no reported safety concerns (1).