The SepsEast 2016 Congress, held from November 9-11, 2016 in Budapest, Hungary, is one of the most important critical care conferences in eastern and central Europe, drawing approximately 450 physicians and healthcare professionals from more than 25 countries. CytoSorbents was the exclusive Diamond Sponsor at the conference.

The CytoSorbents sponsored research symposium was well-attended with more than 200 participants interested in learning more about CytoSorb from the following agenda:

Cytokine adsorption – its place and perspectivesDr. Dana Tomescu, Romania

Highlights from the meeting:

Prof. Zsolt Molnar presented an interim analysis of the randomized, controlled ACESS Trial, evaluating the early use of CytoSorb in patients with septic shock. The early data suggest strong improvements in hemodynamic stability in patients receiving both standard of care therapy and CytoSorb, versus those receiving standard of care alone.

Dr. Klaus Kogelmann presented data from a prospectively defined case series evaluating CytoSorb treatment in septic shock patients with multi-organ failure, correlating improved hemodynamic stability and survival when CytoSorb was used within the first 24 hours of septic shock.

Dr. Axel Nierhaus and Dr. Dana Tomescu individually described the growing usage of the CytoSorb therapy at their respective hospitals in a variety of different applications.

A panel of active CytoSorb users led by Dr. Axel Nierhaus agreed upon the first consensus statement on CytoSorb use, where they concluded:

CytoSorb is safe and easy to implement and can be used as an adjunctive therapy to standard medical treatment in patients with septic shock

CytoSorb therapy should be administered early after the onset of septic shock (within 6-24 hours) if possible

Patients with refractory septic shock may benefit from treatment with CytoSorb if they receive sufficient guideline based resuscitation and achieve good control over the infection

More frequent changes of the CytoSorb adsorber should be considered according to the clinical picture and response of the patient

All users should take part in the International CytoSorb Registry, which will facilitate better clinical studies in these complex and critically-ill patients

There are more than two dozen new publications involving CytoSorb therapy, ranging from case reports, case series, and small randomized controlled studies that have been submitted or are being prepared for submission to peer-reviewed scientific journals. These studies report on the use of CytoSorb therapy in a wide range of applications including sepsis, cardiac surgery, post-operative inflammation, liver failure, trauma, and many others.

About CytoSorbents Corporation (NASDAQ: CTSO)

CytoSorbents Corporation is a leader in critical care immunotherapy, specializing in blood purification. Its flagship product, CytoSorb® is approved in the European Union with distribution in 42 countries around the world, as a safe and effective extracorporeal cytokine adsorber, designed to reduce the “cytokine storm” or “cytokine release syndrome” that could otherwise cause massive inflammation, organ failure and death in common critical illnesses such as sepsis, burn injury, trauma, lung injury and pancreatitis, as well as in cancer immunotherapy. These are conditions where the risk of death is extremely high, yet no effective treatments exist. CytoSorb® is also being used during and after cardiac surgery to remove inflammatory mediators, such as cytokines and free hemoglobin, which can lead to post-operative complications, including multiple organ failure. CytoSorbents has completed its REFRESH (REduction in FREe Hemoglobin) 1 trial – a multi-center, randomized controlled study that has demonstrated the safety of intra-operative CytoSorb® use in a heart-lung machine during complex cardiac surgery. In 2017, the company plans to initiate a pivotal REFRESH 2 trial intended to support U.S. FDA approval. CytoSorb® has been used safely in more than 17,000 human treatments to date.

CytoSorbents’ purification technologies are based on biocompatible, highly porous polymer beads that can actively remove toxic substances from blood and other bodily fluids by pore capture and surface adsorption. Its technologies have received non-dilutive grant and contract funding in excess of $18 million from DARPA, the U.S. Army, the U.S. Air Force, the U.S. Department of Health and Human Services, the National Institutes of Health (NIH), National Heart, Lung, and Blood Institute (NHLBI), U.S. Special Operations Command (SOCOM) and others. The Company has numerous products under development based upon this unique blood purification technology, protected by 32 issued U.S. patents and multiple applications pending, including CytoSorb-XL, HemoDefend™, ContrastSorb, DrugSorb, and others. For more information, please visit the Company’s websites: https://cytosorbents.com and http://www.cytosorb.com or follow us on Facebook and Twitter.

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