Wyn was born one of eight children of Meyer & Dora Schiffman, of Jewish ancestry. The family moved to the U.S. in 1905 and settled in New York City, where Meyer worked as a salesman for a printing company, later starting his own printing business, Schiffman & Sons, at 64 East Eighth Street, near Broadway in Greenwich Village. By June of 1922, Rose Schiffman had completed her sophomore year at college and began working as a bookkeeper at the family printing business, now "Schiffman Brothers" (after the death of the father). On February 19, 1926 Rose married Aaron Abraham Weinstein, more often listed as "A. A. Wyn".

A. A. Wyn began working at "Magazine Publishers" about 1929, is an Associate Editor in 1930, an Editor in 1931, and then Publisher in 1932. Rose Wyn begins working with him at this company, probably in 1932, but by 1933 at the latest. By the fall of 1933, she was an editor for Periodical House. Following the trend of adventure magazines such as "The Shadow" (1931), "Doc Savage" (1933), and "Phantom Detective" (1933), Rose brainstormed with writer Paul Chadwick to create a hero in this line. The result was "Secret Agent X", a composite of those three heroes. The first issue of the pulp magazine "Secret Agent X" appeared in late 1933 (with a cover date of Feb. 1934), and continued for 41 issues up to March 1939. "For Secret Agent X, Rose Wyn decided to pit him against villains who were maestros of unbridled horror", initiating a sub-genre later known as "weird menace". Although ostensibly in the crime genre, the Secret Agent X stories were situated at the more far-fetched end of the spectrum, with a number of science fiction elements such as futuristic weapons and mad scientists.

Wyn was the co-owner (1940-1956) and editor (1944-1951) of Ace Comics with her husband as an extension of their pulp publishing enterprises, Periodical House and Magazine Publishers. Included among the titles she supervised were Complete Love, Ten Story Love, and Secret Agent X.[1]

The Wyns had two children, Ronald and Susan (later Schofer); Ronald died young in the 1960s, probably of a drug overdose. Aaron Wyn died in 1967 in New York at the age of 69. Rose Wyn died in 1992 in Wilmette, Illinois at the age of 88.