In 2017, the International Treatment Preparedness Coalition (ITPC) embarked on an initiative to develop and implement innovative community-led demand creation solutions for access to and use of oral pre-exposure prophylaxis (PrEP) of HIV by key populations. This initiative included a preliminary literature review of global community perspectives on PrEP, the Community-led Consultative Think Tank Meeting on PrEP, and development of the Key Population Activist Toolkit on PrEP. This document includes the seven points that were developed from this consultative process and articulates key PrEP messages from key population networks and PrEP experts.