Hallucinogens

What are hallucinogens?

Hallucinogens are a diverse group of drugs that alter perception (awareness of surrounding objects and conditions), thoughts, and feelings. They cause hallucinations, or sensations and images that seem real though they are not. Hallucinogens can be found in some plants and mushrooms (or their extracts) or can be human-made. People have used hallucinogens for centuries, mostly for religious rituals. Common hallucinogens include the following:

Photo by DEA
Blotter sheet of LSD-soaked paper squares that users take by mouth

Ayahuasca is a tea made from one of several Amazonian plants containing dimethyltryptamine (DMT), the primary mind-altering ingredient. Ayahuasca is also known as Hoasca, Aya, and Yagé.

DMT is a powerful chemical found in some Amazonian plants. Manufacturers can also make DMT in a lab. The drug is usually a white crystalline powder. A popular name for DMT is Dimitri.

D-lysergic acid diethylamide (LSD) is one of the most powerful mood-changing chemicals. It is a clear or white odorless material made from lysergic acid, which is found in a fungus that grows on rye and other grains. LSD has many other names, including Acid, Blotter, Dots, and Yellow Sunshine.

Peyote (mescaline) is a small, spineless cactus with mescaline as its main ingredient. Peyote can also be synthetic. Buttons, Cactus, and Mesc are common names for peyote.

4-phosphoryloxy-N,N-dimethyltryptamine (psilocybin) comes from certain types of mushrooms found in tropical and subtropical regions of South America, Mexico, and the United States. Other names for psilocybin include Little Smoke, Magic Mushrooms, Purple Passion, and Shrooms.

Some hallucinogens also cause users to feel out of control or disconnected from their body and environment. Common examples include the following:

Dextromethorphan (DXM) is a cough suppressant and mucus-clearing ingredient in some over-the-counter cold and cough medicines (syrups, tablets, and gel capsules). Robo is another popular name for DXM.

Ketamine is used as a surgery anesthetic for humans and animals. Much of the ketamine sold on the streets comes from veterinary offices. While available as an injectable liquid, manufacturers mostly sell it as a powder or as pills. Other names for ketamine include K, Special K, or Cat Valium.

Phencyclidine (PCP) was developed in the 1950s as a general anesthetic for surgery. It’s no longer used for this purpose due to serious side effects. While PCP can be found in a variety of forms, including tablets or capsules, liquid and white crystal powder are the most common forms. PCP has various other names, such as Angel Dust, Hog, Love Boat, and Peace Pill.

Salvia divinorum (salvia) is a plant common to southern Mexico and Central and South America. Other names for salvia are Diviner's Sage, Maria Pastora, Sally-D, and Magic Mint.

How do people use hallucinogens?

How do hallucinogens affect the brain?

Research suggests that hallucinogens work at least partially by temporarily disrupting communication between brain chemical systems throughout the brain and spinal cord. Some hallucinogens interfere with the action of the brain chemical serotonin, which regulates:

mood

sensory perception

sleep

hunger

body temperature

sexual behavior

muscle control

Other hallucinogens interfere with the action of the brain chemical glutamate, which regulates:

pain perception

responses to the environment

emotion

learning and memory

Short-Term Effects

The effects of hallucinogens can begin within 20 to 90 minutes and can last as long as 6 to 12 hours. Salvia's effects are more short-lived, appearing in less than 1 minute and lasting less than 30 minutes. Hallucinogen users refer to the experiences brought on by these drugs as "trips," calling the unpleasant experiences "bad trips."

Along with hallucinations, other short-term general effects include:

increased heart rate

nausea

intensified feelings and sensory experiences

changes in sense of time (for example, time passing by slowly)

Specific short-term effects of some hallucinogens include:

increased blood pressure, breathing rate, or body temperature

loss of appetite

dry mouth

sleep problems

mixed senses (such as "seeing" sounds or "hearing" colors)

spiritual experiences

feelings of relaxation or detachment from self/environment

uncoordinated movements

excessive sweating

panic

paranoia—extreme and unreasonable distrust of others

psychosis—disordered thinking detached from reality

Long-Term Effects

Little is known about the long-term effects of hallucinogens. Researchers do know that ketamine users may develop symptoms that include ulcers in the bladder, kidney problems, and poor memory. Repeated use of PCP can result in long-term effects that may continue for a year or more after use stops, such as:

Flashbacks—recurrences of certain drug experiences. They often happen without warning and may occur within a few days or more than a year after drug use. In some users, flashbacks can persist and affect daily functioning, a condition known as hallucinogen persisting perceptual disorder (HPPD). These people continue to have hallucinations and other visual disturbances, such as seeing trails attached to moving objects.

Symptoms that are sometimes mistaken for other disorders, such as stroke or a brain tumor

What are other risks of hallucinogens?

Other risks or health effects of many hallucinogens remain unclear and need more research. Known risks include the following:

Some psilocybin users risk poisoning and possibly death from using a poisonous mushroom by mistake.

High doses of PCP can cause seizures, coma, and death, though death more often results from accidental injury or suicide during PCP intoxication. Interactions between PCP and depressants such as alcohol and benzodiazepines (prescribed to relieve anxiety or promote sleep—alprazolam [Xanax®], for instance) can also lead to coma.

Some bizarre behaviors resulting from hallucinogens that users display in public places may prompt public health or law enforcement personnel intervention.

While hallucinogens' effects on the developing fetus are unknown, researchers do know that mescaline in peyote may affect the fetus of a pregnant woman using the drug.

Are hallucinogens addictive?

Evidence indicates that certain hallucinogens can be addictive or that people can develop a tolerance to them. Use of some hallucinogens also produces tolerance to other similar drugs.

For example, LSD is not considered an addictive drug because it doesn't cause uncontrollable drug-seeking behavior. However, LSD does produce tolerance, so some users who take the drug repeatedly must take higher doses to achieve the same effect. This is an extremely dangerous practice, given the unpredictability of the drug. In addition, LSD produces tolerance to other hallucinogens, including psilocybin.

On the other hand, PCP is a hallucinogen that can be addictive. People who stop repeated use of PCP experience drug cravings, headaches, and sweating as common withdrawal symptoms.

Scientists need more research into the tolerance or addiction potential of hallucinogens.

How can people get treatment for addiction to hallucinogens?

There are no government-approved medications to treat addiction to hallucinogens. While inpatient and/or behavioral treatments can be helpful for patients with a variety of addictions, scientists need more research to find out if behavioral therapies are effective for addiction to hallucinogens.

Points to Remember

Hallucinogens are a diverse group of drugs that alter perception, thoughts, and feelings. They cause hallucinations, or sensations and images that seem real though they are not. Some hallucinogens also cause users to feel out of control or disconnected from their body and environment.

People use hallucinogens in a wide variety of ways, including smoking, snorting, and absorbing through the lining in the mouth.

Hallucinogens interfere with actions of brain chemicals responsible for functions that include:

mood

sensory perception

sleep

body temperature

muscle control

pain perception

memory

The effects of hallucinogens can begin within 20 to 90 minutes and can last as long as 6 to 12 hours.

Along with hallucinations, other short-term general effects of hallucinogens include:

increased heart rate

nausea

intensified feelings and sensory experiences

changes in sense of time

Persistent psychosis and flashbacks are two long-term effects associated with some hallucinogens.

Evidence indicates that certain hallucinogens can be addictive or that people can develop a tolerance to them.

There are no government-approved medications to treat addiction to hallucinogens. Scientists need more research to find out if behavioral therapies are effective for addiction to hallucinogens.

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This publication is available for your use and may be reproduced in its entirety without permission from the NIDA. Citation of the source is appreciated, using the following language: Source: National Institute on Drug Abuse; National Institutes of Health; U.S. Department of Health and Human Services.