“Chuck Quizmo's the name, and quizzes are my game! You want quizzes, I got 'em! If you can manage to answer my brain-busting questions correctly, then... Y... Yaa... Yaaaaaahooo! I'll give you a Star Piece! Want to try a quiz?”—Chuck Quizmo, Paper Mario

Chuck Quizmo is a character in the Nintendo 64 game Paper Mario. A multi-colored worm wearing a yellow bow tie and a top hat, Chuck Quizmo host a quiz game which Mario can participate in to receive Star Pieces. His name may be a reference to the game show host Chuck Woolery.

Quizmo appears throughout Paper Mario in different towns and villages, and if Mario speaks with him, Quizmo will transport him to a stage and, along with his assistant Vanna T., ask Mario a question. If Mario answers Chuck's quiz correctly, he will be rewarded with a Star Piece, and if he answers wrong, he will receive nothing. In the latter case, the same question will be asked the next time Mario speaks with him, thereby still allowing the player to receive all the Star Pieces. After quizzing Mario, Quizmo will teleport away to a different location. In all, Quizmo will ask sixty-four questions, provided Mario makes the effort to find him and accept his quizzes.

If Mario answers all of his questions correctly, Quizmo states that, now that he has found someone with all the answers, he can finally retire as quiz master. After Mario defeats Bowser, Quizmo, along with Vanna T., can be seen in Toad Town outside the dojo; when spoken to, Quizmo will jokingly ask Mario if he wants to participate in another quiz before stating he is in Toad Town merely to attend the festival celebrating the defeat of the Koopa Troop. Quizmo can also be seen in the parade that plays during the Paper Mario credits, expelling fireworks from his hat.

In the original Japanese script of Paper Mario: The Thousand-Year Door and most translations of the game, the final RDM email mentions that Chuck Quizmo (revealed to be 44-years old) is soon set to return in a new quiz named "The Impartial Judge!". The English translation of the game removed the potion of the email where Chuck Quizmo is mentioned, while the French translation substitutes his name with Vanna T.

He's Chuck Quizmo. He tries to quiz anybody who speaks to him. He pops up in various towns and villages, but that doesn't mean he's easy to find. What do you think his deal is? Personally, I'm a little more interested in his assistant. She's cute!

Chuck Quizmo's quiz was the beginning of the running gag of quizzes in the Paper Mario series taking place in a game show stage, despite Mario never moving from where he found Quizmo (such as Koopa Village). This quiz also had the first audience in a Paper Mario game, though it had no function.

MC Ballyhoo from Mario Party 8 bears a resemblance to Chuck Quizmo, mostly because of the huge top hats the two characters wear.

Chuck Quizmo asks a total of 64 questions. This is likely a reference to the Nintendo 64.