Diffuse light in tissue can be a very interesting tool for medical diagnosis, especially if one considers the fluctuations of
the speckle pattern. Of course, speckle analysis suffers from the low spatial coherence of speckle patterns, and multipixel
detection is required in order to increase the signal to noise ratio. There is therefore a need of a setup with a high
sensitivity, capable of outputting a signal from noise through averaging on a high number of pixels, as the signal can be
lower than the photon level for one image and one frame. Furthermore, such a processing has to be done at a very high
acquisition rate. “Smart-pixels” arrays can represent a major breakthrough in this field.