The need in bone-plastic material of various types and sizes is constantly increasing. Reconstructive operations with the use of this material are constantly conducted after obtaining industrial injuries, military conflicts, diseases of the muscu-loskeletal system, rejuvenation of osteoporosis, etc. At the same time, the quality of implants is evaluated, first of all, by their osteinductive properties. However, ensuring the safety of the recipient, determined by reliable sterilization of the plas-tic material is also important. On the other hand, the sterilization process should not lead to impairment of the properties of the implant.The main goal of this work is to analyze existing and to develop new technological approaches to an effective sterilization while reducing the risk of side effects from sterilizing process.Currently, the following traditionally used implant sterilization technologies are:1. steam sterilization (autoclaving);2. cryostyrenization;3. chemical sterilization (sterilization using special solutions);4. gas sterilization (ethylene oxide, formaldehyde vapor, etc.);5. radiation (gamma radiation or fast electrons);Sterilization performed with steam, air and gas sterilizers, characterized by the heating process, does not allow the processing on temperature sensitive materials, including biological tissues. Chemical sterilization is very toxic, and the degree of its effectiveness depends on the exposure and concentration of the used drugs. In addition to toxicity, chemical methods have a number of other limitations. For example, the use of formalin with the addition of an antibiotic as a preservative and a sterilizer entails a number of problems due to a shorter transplant storage time (no more than 6 months), the need for washing the prepared graft before clinical use, formalin toxicity, and the inconvenience of storing and transporting the grafts immersed in a formalin solution.Radiation processing is the most effective sterilizing action. Radiation sterilization has several advantages: high penetrating power, relatively low temperature rise. However, a review of a number of studies has shown that serious changes occur in biological tissues during high-dose radiation sterilization.The way out of this situation can be the use of combined effects of various physical and chemical factors. In this case, the impact of each of the factors separately can be less intense and introduce fewer changes in the native structure of the im-plant. However, their combined use can lead to a synergistic effect that provides an adequate level of sterilization. In order to overcome the above drawbacks, an additional sterilizing factor was proposed to use as a sterilization method comprising treating the implant in two steps with an ozone-air mixture.The obvious advantages of ozone sterilization is, first of all, low-temperature process, relatively short exposure, deep pene-tration into the material, the ability to sterilize temperature-resistant products, the ability to work with sterilization cham-bers of a large volume, the lack of toxicity, as well as environmental safety.In this study we confirm the possibility of implementing of a combined method for bone implants sterilization, including initial impact on the samples by an ozone-air mixture and subsequent irradiation with fast electrons with an absorbed dose of 11-15 kGy. This result demonstrates the effectiveness of the combined method of sterilization of bone implants.