My specs for my desktop should be in my signature, and I have no trouble running Dolphin 3.5 at stock.

I just want to know what settings you guys use for your high-end desktops (and notebooks if they can be considered high-end).
I plan on making lets plays/streams/machinima with OpenBroadcaster. I'm trying to get the best results for this by maxing-out settings that make a difference in terms of quality, without any speeding up/down, or anything else undesired.

You can also set texture accuracy to fast as that shouldn't cause any issues with this game.
Last but not least, you can set the DSP Audio Engine to LLE for better sound (accuracy) at the cost of performance.
You can also try the latest development builds which distributes the reverse engineered roms for LLE, has improvements on HLE and has some new options.