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January 22, 2007: Study Links Antidepressants to Bone Fractures in Older Patients A new study finds that use of certain antidepressants by older patients exposes them to an increased risk of suffering bone fractures. The study, carried out by a number of Canadian research scientists, suggests that patients over 50 years of age who take Selective Serotonin Reuptake Inhibitors (SSRIs) on a daily basis -- including Celexa, Fluvoxamine, Paxil, Prozac, and Zoloft -- are twice as likely to suffer bone fractures. Read an Abstract of the Study, from the Archives of Internal Medicine.

December 5, 2006: FDA to Review Suicide Risk for Young Adults Taking Antidepressants The U.S. Food and Drug Administration (FDA) announced a December 13 meeting of outside medical experts who will consider new data on the increased risk of "suicidality" (suicidal thinking and behavior) in young adults taking antidepressant medications. This meeting is a follow-up to two meetings on antidepressants and suicidality in pediatric patients held in February and September, 2004. The FDA states that it plans to modify antidepressant drug labels based on the panel's findings.

July 2006: FDA Says Combined Use of Prozac and Migraine Medicines Risky The U.S. Food and Drug Administration (FDA) issued an alert concerning Prozac use, specifically the risks associated with the combined use of selective serotonin reuptake inhibitors (SSRIs, such as Prozac) and triptans (used to treat migraine headaches). Combined use can lead to a life-threatening condition called serotonin syndrome. Click here to read more from the FDA.

July 2006: FDA Advises of Treatment Challenges for Depression in Pregnancy The FDA issued a public health advisory about the potential risks of using Prozac and other antidepressants during pregnancy, announcing the results of a study examining the use of antidepressant medicines during pregnancy in mothers of babies born with a serious condition called persistent pulmonary hypertension of the newborn (PPHN). Babies born with PPHN have abnormal blood flow through the heart and lungs and do not get enough oxygen to their bodies. Click here to read more from the FDA.

June 30, 2005: Suicidality in Adults Being Treated with Antidepressant MedicationsThe FDA issued a public health advisory announcing that several recent scientific publications suggested the possibility of an increased risk for suicidal behavior in adults being treated with antidepressant medications, including Prozac. The FDA advised that adults taking antidepressants (particularly those being treated for depression) should be watched closely for worsening depression and increased suicidality. Monitoring these patients is especially important when treatment beings and when doses are increased or decreased. The FDA is working closely with antidepressant manufacturers to fully evaluate the risk of suicidality in adults treated with these medications. Click here to read more.

October 15, 2004: FDA Orders Re-Labeling on Suicidality in Child and Adolescent Antidepressant Patients The FDA issued a public health advisory directing all antidepressant drug manufacturers to revise their products' labeling to include boxed warning and expanded warning statements that alert healthcare providers to an increased risk of suicidality (suicidal thinking and behavior) in children and adolescents being treated with these medications. In response to the FDA advisory, Eli Lilly and Company (manufacturer of Prozac) has added a box warning to the safety information section of the Prozac website.

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