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This chapter examines the evidence of preabsorptive sites of satiating stimuli. It emphasizes the importance of experimental control of chemical and mechanical stimuli in the mouth, stomach, and small intestine. It is known in this review that the combination of pregastric and gastric stimuli of ingested food can control meal size within the normal range of 0.5–19 hours of food deprivation with various test diets. The satiating effect of the combination of pregastric and gastric stimuli has been observed in rat pups less than two weeks old and the chapter notes that it is the sequential combi...

This chapter examines the evidence of preabsorptive sites of satiating stimuli. It emphasizes the importance of experimental control of chemical and mechanical stimuli in the mouth, stomach, and small intestine. It is known in this review that the combination of pregastric and gastric stimuli of ingested food can control meal size within the normal range of 0.5–19 hours of food deprivation with various test diets. The satiating effect of the combination of pregastric and gastric stimuli has been observed in rat pups less than two weeks old and the chapter notes that it is the sequential combination of pregastric and gastric stimuli that occurs during eating that is sufficient to control meal size within the normal range.