Dabrafenib is a new drug approved for treating patients with melanoma. It is also being assessed in patients with certain types of brain tumors and other tumors that contain a V600E mutation in a gene called BRAF. It is designed to inhibit cancer growth by blocking the activity of the BRAF protein, which is abnormal in some cancers.

The purpose of this study is to find the highest dose of dabrafenib that can be given safely in children with advanced solid tumors (particularly brain tumors) that contain the V600E BRAF mutation. Dabrafenib is a pill that is taken orally (by mouth).