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A CROSS-SECTIONAL EXAMINATION: IMPACT OF DIET AND PHYSICAL
ACTIVITY ON PLASMA GLUCOSE METABOLISM, INSULIN SENSITIVITY AND
PANCREATIC Β-CELL FUNCTION IN HISPANIC WOMEN WITH HISTORIES OF
GESTATIONAL DIABETES MELLITUS
by
Xinwen Liu
A Thesis Presented to the
FACULTY OF THE USC GRADUATE SCHOOL
UNIVERSITY OF SOUTHERN CALIFORNIA
In Partial Fulfillment of the
Requirements for the Degree
MASTER OF SCIENCE
(BIOSTATISTICS)
December 2009
Copyright 2009 Xinwen Liu

The association between diet or physical activity (PA) and insulin sensitivity (IS), as well as β-cell function (BCF), has not been adequately examined. The purpose of the study is to cross-sectionally investigate this association in women with a history of gestational diabetes mellitus (GDM). Demographics, diet and PA data were collected using questionnaires; glucose metabolic measures (GMM) by OGTT and IVGTT. Among the 127 Hispanic women included in this report, we observed statistically significant differences in BMI and GMM between the 102 GDM patients and 25 controls; however, no differences were found in diet/PA. Diets high in carbohydrate, zinc, calcium and vitamin D seemed to be correlated with improved glucose control, IS and BCF. In addition, these beneficial effects were seen for exercise alone. These results highlight the importance of exercise in improving IS and BCF in women with a history of GDM to prevent the development of T2DM.

A CROSS-SECTIONAL EXAMINATION: IMPACT OF DIET AND PHYSICAL
ACTIVITY ON PLASMA GLUCOSE METABOLISM, INSULIN SENSITIVITY AND
PANCREATIC Β-CELL FUNCTION IN HISPANIC WOMEN WITH HISTORIES OF
GESTATIONAL DIABETES MELLITUS
by
Xinwen Liu
A Thesis Presented to the
FACULTY OF THE USC GRADUATE SCHOOL
UNIVERSITY OF SOUTHERN CALIFORNIA
In Partial Fulfillment of the
Requirements for the Degree
MASTER OF SCIENCE
(BIOSTATISTICS)
December 2009
Copyright 2009 Xinwen Liu