These hormones are normally secreted by the placenta, which maintains the Corpus Luteum of
pregnacy. Concentrations vary with the phase of the menstrual cycle. Their production is
regulated by a negative feedback effect.

Human Chorionic gonadotropin actions are similar to those of luteinizing hormone (LH), which is produced by the pituitary gland. It is a hormone also normally produced by the placenta in pregnancy.It helps to maintain pregnancy. Chorionic gonadotropin has different effects in females and males. In females, chorionic gonadotropin is used to induce conception . It is usually given in combination with other drugs such as menotropins and urofollitropin. Many females being treated with these drugs usually have already tried clomiphene alone without success. Chorionic gonadotropin is also used in in vitro fertilization (IVF) programs. In males, LH and chorionic gonadotropin stimulate the testes to produce male hormones such as testosterone.

HCG is administered as intramuscular or subcutaneous injections. For treating males with problems related to low levels of male hormones 1000 to 4000 Units, two to three times a week. To induce conception, 5000 to 10,000 Units administered in mid-cycle.

HCG may be contraindicated in: Cancer of the prostate: Increases in the amount of testosterone in the bloodstream may make this condition worse. Ovarian Cyst or Fibroid tumors of the uterus: Chorionic gonadotropin can cause increase in the size of cyst

Allergies to HCG may occur. Pregnancy : If this drug is used with menotropins or urofollitropin, there is an increased chance of multiple pregnancy. Children : Chorionic gonadotropin, when used for treating cryptorchidism, has caused the sexual organs of some male children to develop very rapidly.