MI Profile™ offers comprehensive tumor biomarker analyses coupled with an extensive clinical literature evidence review, which matches potential therapies to patient-specific biomarker information. Oncologists are provided simple-to-read reports indicating which available chemotherapeutic, biologic and hormone therapies are potentially effective, along with those that are potentially less effective, based on the molecular profiling results. The report further provides information on appropriate and enrolling clinical trials for the patient. This service presents clinically-relevant, patient-specific information doctors can use to individualize cancer treatment.

Unlike other tumor profiling services on the market, which are often powered by a single technology platform, or hinge on the successful exploitation of a particular DNA mutation, Caris remains both technology- and biomarker-agnostic, employing a wide range of technologies to uncover a broad array of key biomarkers. With this unique approach, the company currently reports potentially clinically-relevant biomarker to drug associations in approximately 95 percent of patient cases, averaging more than 25 possible clinically-actionable biomarkers per patient.

"Evaluating DNA only doesn't address the true complexity of the biology driving the cancer. It is essential to consider the significant impact of RNA and downstream alterations of the proteins involved in each patient's disease," said David D. Halbert , Chairman and Chief Executive Officer of Caris Life Sciences. "It's imperative to perform a holistic and comprehensive analysis on a tumor, especially the proteins, which are the active agents. Anything less does a disservice to the treating physician and could potentially put a patient at risk."

"Integrating next-generation sequencing further demonstrates our commitment to continually evolve with emerging science to provide our physicians with an unmatched comprehensive tumor profiling service," said Tom Spalding , Senior Vice President & Group Head, Oncology, Caris Life Sciences. "As a result of this comprehensive approach, we believe we can provide significantly greater clinical utility than services that solely rely on single technology platforms. For example, NGS analysis alone would not provide oncologists with key insights into some of the most commonly used companion diagnostics, as FDA-approved labeling requires the use of specific and varied profiling technologies."

NGS will power the mutational analyses performed in the company's Select and Comprehensive profiles, enabling rapid examination and broader detection of somatic mutations across hundreds of hotspots in the cancer genome. Additionally, this critical technology enables the inclusion of emerging biomarkers that may have potential clinical or research applications. The addition of these emerging biomarkers will further enhance the utility of the Caris Registry®, which houses critical data on biomarker, drug and patient outcomes that may yield greater insights into the treatment of various cancers.

"From both breadth of information and research utility perspectives, NGS is most valuable when combined with other technologies like IHC and FISH to more comprehensively assess a patient's tumor,"said Sandeep Reddy , M.D., Clinical Professor of Medicine at the David Geffen School of Medicine at the University of California, Los Angeles (UCLA) and Senior Medical Director at Caris Life Sciences. "Sequencing alone may provide relevant results in smaller percentages of cancer patients, giving the treating physician only part of the full molecular picture. In contrast, Caris provides more meaningful biomarker analysis and delivershighly thorough interrogation of important biomarkers in the cancer pathway. Additionally, Caris' approach also allows for compliance with FDA labeling on approved companion diagnostics."

With more than 45,000 patients profiled to date, Caris Life Sciences houses the most comprehensive collection of biomarker profiles in the industry today. Beyond obvious research implications, this extensive database provides clinicians with critical information about the prevalence of biomarkers in unexpected disease states, allowing them to select personalized, tailored therapy regimens for their patients.

About Caris Life Sciences Caris Life Sciences is a leading biosciences company focused on fulfilling the promise of personalized medicine. Caris' Molecular Intelligence™ Service (MI Profile™) correlates molecular data generated from a patient's tumor with biomarker/drug associations derived from the world's leading clinical cancer literature. This service uses the most advanced and clinically-relevant technologies to provide physicians with information to aid in the selection of personalized cancer treatments more likely to work for each patient. Caris is also developing a series of blood tests based on the company's proprietary Carisome® platform — a blood-based testing technology for diagnosis, prognosis, and theranosis of cancer and other complex diseases. Headquartered in the Dallas metroplex, Caris Life Sciences offers services throughout the United States, Europe, and other international markets. To learn more, please visit www.carislifesciences.com.

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