The big snag with "less glyphs" is that there are too many gods that reward glyph conversion. GG, Taurog, and JJ all offer piety, and Mystera's refreshment is fueled by glyph conversion. That's half the pantheon directly hampered by less glyphs, and one could arguably add Dracul to the list since a CYDSTEPP or HALPMEH find is also worth piety with him.

I might consider this for a Tikki Tooki Paladin run, since the only glyphs I really need are assured finds anyways, but I don't see the use otherwise. If I'm going for a fireball specialist I probably want my options open with Mystera, and if I'm going with a berserker-type character I'm probably prepping Taurog and less glyphs means less piety.

Hmm... true. Could be nice for excessive potion warlords (especially if you get 25/20 mp) using Mysteria and various items. Nevermind on Tiki 2. I didn't realize I automatically got first strike on the boss.