One of the most prolific and versatile composers of his time, Lassus wrote over 2000 works in all Latin, French, Italian and German vocal genres known in his time. These include 530 motets, 175 Italian madrigals and villanellas[?], 150 French chansons[?], and 90 German lieder.

Almost 60 masses have survived complete; most of them are parody masses based on secular works written by himself or other composers. Among his other liturgical compositions are hymns, canticles[?] (including over 100 Magnificats), responsories for Holy Week, Passions, Lamentations[?], and some independent pieces for major feasts.