The Patriots and Falcons opened Sunday favored by roughly a touchdown in their games against the Titans and Browns, respectively.

The two teams ended the day searching for answers after losing big in upsets on the road.

In Nashville, Marcus Mariota passed for 228 yards and two touchdowns and running back Derrick Henry rushed for 58 yards and two scores as the Titans thumped the Patriots, 34-10. The Titans' defense sacked Tom Brady three times and held the high-scoring Pats offense to 284 total yards. The Patriots fell to 7-3, while the Titans are 5-4.

In Cleveland, Browns rookie running back Nick Chubb rushed for 176 yards, added 33 more through the air and scored twice as the Browns upset Atlanta, 28-16. He also provided the highlight of the day with a 92-yard TD run, the longest in franchise history.

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Elsewhere, the two Los Angeles teams faced challenges but prevailed. In Oakland, Chargers quarterback Philip Rivers didn't have a completion until the second quarter, but once he and running back Melvin Gordon got rolling, LA won 20-6 to improve to 7-2.

The Rams, who had never lost back-to-back games in the Sean McVay era, were close to doing so Sunday when they hosted the Seahawks. Seattle quarterback Russell Wilson tried to engineer one of his famous fourth-quarter comebacks but fell short, going four-and-out on the final drive. Los Angeles (9-1) claimed a 36-31 victory to solidify its spot atop the NFC West.

Another game also came down to the final series as the Eagles were hoping to get within reach of the Cowboys. The hosting Philadelphia squad marched down the field trailing Dallas by one touchdown, but couldn't catch up to an Ezekiel Elliott powered offense. The Cowboys won 27-20 in Week 10's "Sunday Night Football" matchup.

Injury report

Patriots receiver Julian Edelman injured his ankle in the team's loss to the Titans. He exited the game early and never returned. Other New England players that were injured in the contest were offensive tackle Trent Brown (back) and tight end Dwayne Allen (knee).

New Orleans left tackle Terron Armstead left the Saints' matchup versus the Bengals after sustaining a shoulder injury during the first half. He was then ruled out of the game.

Raiders wide receiver Martavis Bryant was ruled out with a knee injury. A later report stated Bryant suffered a possible PCL tear, and will have an MRI to determine the severity of the injury.

A number of Packers were injured as Green Bay hosted the Dolphins. Safety Kentrell Brice left the game with an ankle injury, linebacker Nick Perry suffered a new injury, and guard Lucas Patrick was evaluated for a concussion.

Bengals cornerback Dre Kirkpatrick was unable to finish the game against the Saints after suffering a concussion.

Miami cornerback Bobby McCain was ruled out of the game with a head injury. Teammate and receiver Jakeem Grant was carted off to the locker room with a leg injury. Fellow receiver DeVante Parker suffered a shoulder injury.

Rams wideout Cooper Kupp suffered another knee injury against the Seahawks and did not return.

By the numbers

Patrick Mahomes threw for his 31st touchdown against the Cardinals, setting the franchise record for most touchdown passes in a single season, breaking a mark set by Len Dawson in 1964.

Patrick Mahomes breaks the Chiefs' franchise single-season record with his 31st Pass TD for the Chiefs.

Quotables

The Redskins suffered a big loss to the Falcons last week. This time around, Washington wasn't going to be on the losing end. Linebacker Ryan Anderson attributed the win to a sense of urgency: “We got our (expletives) kicked last week, so everybody had a sense of urgency. That’s what playing good defense is about. We let them make some plays, they hit us on some stuff. So, we had to just come out and respond. Bend, but don’t break."

The Bills whopped the Jets, 41-10, leaving New York receiver Jermaine Kearse and company frustrated: “Everybody’s frustrated. I understand the fans are frustrated. We’re frustrated. It’s understandable. We’re going to stick together. We’re going to stick with Todd (Bowles, head coach). We’re going to have his back. We’re going to take this bye week, regroup and try to figure this s--- out.”