What a year Chelsea Handler has had. Her E! talk show "Chelsea Lately" is a late-night staple, she hosted the VMAs back in September and she has even become a headlining-making princess on the gossip sites. In the new issue of Glamour, the funny lady opens to Katie Couric up about her big year and the people she spent it with.

The comedian has been spotted on and off with 50 Cent, sparking dating rumors. Both Handler and Fif have always denied that there's anything romantic happening between them, and in the magazine she once again insists that no hanky-panky is going on.

"We're thinking of doing a movie together, so we were talking about that," she explains of her relationship with 50 Cent. "But he's really cute, and I have to be honest, there's a good chance that I will hook up with a rapper at some point."

Handler sparked new headlines this week when, during a stand-up gig, she dissed Angelina Jolie. If you're wondering why the comic has such an attitude toward the screen siren, it may help to know that Handler is friends with Jennifer Aniston.

"Jennifer Aniston makes me laugh. She sends me really, really funny e-mails. She's hilarious and irreverent," Handler says of her gal pal, while adding about Jolie, "I'm not a fan. She just doesn't come off to me as a sincere woman. She seems like a woman that you'd really want to avoid."

So if talking smack about Hollywood stars is allowed, is anything off-limits in her comedy? Well, yes.

"I think talking about children and their looks is not nice," she explains. "And I don't talk about people who are dying."