Four strangers (an older couple, a sailor and a young girl) are quarantined together during the Black Plague's sweep through London. They all attempt to connect to each other by revealing their own truths, exposing others' lies, sharing emotions and attempting to keep the plague out of mind. Unfortunately, there is a constant reminder of the death and decay going on outside those four walls - the guard stationed in front of the couple's home. He calls the numbers of the dead, offers "remedies," strikes deals and preaches to the masses - all while seeming to go mad himself from all the detriment around him. Will the plague, confinement, and socioeconomic differences allow these attempted connections to be anything more than an attempt at self-preservation?