Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer).

In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

nature.com Subject Pages

User tools

Cellular signalling networks

Definition

Cellular signalling networks are formed when different cell signalling pathways interact and are detected by a combination of experimental and computational methods. Understanding how a biological system responds to a signal can be deduced by analysing how multiple cell signalling pathways affect each other and, in turn, cellular processes within the network.

Deregulation of E2F family transcription factors is associated with cancer progression and metastasis. Here, the authors construct a map of the regulatory network around the E2F family, and using gene expression profiles, identify tumour type-specific regulatory cores and receptor expression signatures associated with epithelial-mesenchymal transition in bladder and breast cancer.