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Women and Infants

Public Health Impact

Women and infants disproportionately bear the long term consequences of STDs. Women infected with Neisseria gonorrhoeae or Chlamydia trachomatis can develop PID, which, in turn, may lead to reproductive system morbidity such as ectopic pregnancy and tubal factor infertility. If not adequately treated, 20% to 40% of women infected with chlamydia1 and 10% to 40% of women infected with gonorrhea2 may develop PID. Among women with PID, tubal scarring can cause involuntary infertility in 20%, ectopic pregnancy in 9%, and chronic pelvic pain in 18%.3 Approximately 70% of chlamydial infections and 50% of gonococcal infections in women are asymptomatic.4-6 These infections are detected primarily through screening programs. The vague symptoms associated with chlamydial and gonococcal PID cause 85% of women to delay seeking medical care, thereby increasing the risk of infertility and ectopic pregnancy.7 Data from a randomized controlled trial of chlamydia screening in a managed care setting suggest that such screening programs can reduce the incidence of PID by as much as 60%.8

Human papillomavirus (HPV) infections are highly prevalent, especially among young sexually-active women. While the great majority of HPV infections in women resolve within one year, they are a major concern because persistent infection with specific types are causally related to cervical cancer; these types also cause Pap smear abnormalities. Other types cause genital warts, low grade Pap smear abnormalities and, rarely, recurrent respiratory papillomatosis in infants born to infected mothers.9

Direct Impact on Pregnancy

Gonorrhea and chlamydia can result in adverse outcomes of pregnancy, including neonatal ophthalmia and, in the case of chlamydia, neonatal pneumonia. Although topical prophylaxis of infants at delivery is effective for prevention of gonococcal ophthalmia neonatorum, prevention of neonatal pneumonia requires prenatal detection and treatment.

Genital infections with herpes simplex virus are extremely common, may cause painful outbreaks, and may have serious consequences for pregnant women including potentially fatal neonatal infections.10

When a woman has a syphilis infection during pregnancy, she may transmit the infection to the fetus in utero. This may result in fetal death or an infant born with physical and mental developmental disabilities. Most cases of congenital syphilis are easily preventable if women are screened for syphilis and treated early during prenatal care.11

Observations

Chlamydia – United States

Between 2005 and 2006, the rate of chlamydial infections in women increased from 492.2 to 515.8 per 100,000 females (Figure 1, Table 4). Chlamydia rates exceed gonorrhea rates among women in all states (Figures A and B, Tables 4 and 14).

Family Planning Clinics - In 2006, the median state-specific chlamydia test positivity among 15- to 24-year-old women who were screened during visits to selected family planning clinics in all states and outlying areas was 6.7% (range 2.8% to 16.9%) (Figures 8 and 9).

Gonorrhea – United States

Like chlamydia, gonorrhea is often asymptomatic in women. Gonorrhea screening, therefore, is an important strategy for the identification of gonorrhea among women. Large-scale screening programs for gonorrhea in women began in the 1970s. After an initial increase in cases detected through screening, gonorrhea rates for both women and men declined steadily throughout the 1980s and early 1990s, and then reached a plateau (Figure 11). The gonorrhea rate for women (124.3 per 100,000 females) increased slightly in 2006 for the second consecutive year (Table 14).

Although the gonorrhea rate in men has historically been higher than the rate in women, the gonorrhea rate among women has been higher than the rate among men for six consecutive years (Figure 12 and Tables 14 and 15).

Family Planning Clinics - In 2006, the median state-specific gonorrhea test positivity among 15- to 24-year-old women screened in selected family planning clinics in 43 states, Puerto Rico, the District of Columbia, and the Virgin Islands was 1.1% (range 0.0%-4.8%) (Figure 21). Median gonorrhea positivity in family planning clinics has shown minimal change in recent years.

Primary and Secondary Syphilis by State

The HP 2010 target for primary and secondary (P&S) syphilis is 0.2 cases per 100,000 population. In 2006, 32 states, the District of Columbia, and two outlying areas had rates of P&S syphilis for women that were greater than 0.2 case per 100,000 population (Table 26).

Congenital Syphilis

The HP 2010 target for congenital syphilis is 1.0 case per 100,000 live births. In 2006, 26 states, the District of Columbia, and Puerto Rico had rates higher than this target (Table 38).

Trends in congenital syphilis usually follow trends in P&S syphilis among women, with a lag of one to two years (Figure 37). The congenital syphilis rate peaked in 1991 at 107.3 cases per 100,000 live births, and declined by 92.4% to 8.2 cases per 100,000 live births in 2005 (Figure 38, Table 39). The rate of P&S syphilis among women declined 94.8% (from 17.3 to 0.9 cases per 100,000 females) during 1990–2005 (Figure 27).

After 14 years of decline in the United States, the rate of congenital syphilis increased 3.7% between 2005 and 2006 (from 8.2 to 8.5 cases per 100,000 live births) (Figure 38, Table 39).

The 2006 rate of congenital syphilis for the United States is currently 8.5 times higher than the HP 2010 target of 1.0 case per 100,000 live births (Table 38).

While most cases of congenital syphilis occur among infants whose mothers have had some prenatal care, late or limited prenatal care has been associated with congenital syphilis. Failure of health care providers to adhere to maternal syphilis screening recommendations also contributes to the occurrence of congenital syphilis.13

Pelvic Inflammatory Disease

Accurate estimates of pelvic inflammatory disease (PID) and tubal factor infertility resulting from gonococcal and chlamydial infections are difficult to obtain. Definitive diagnoses of these conditions can be complex. Hospitalizations for PID have declined steadily throughout the 1980s and early 1990s, but have remained relatively constant between 1995 and 2005 (Figure H). Accurate estimates of pelvic inflammatory disease (PID) and tubal factor infertility resulting from gonococcal and chlamydial infections are difficult to obtain. Definitive diagnoses of these conditions can be complex. Hospitalizations for PID have declined steadily throughout the 1980s and early 1990s14,15 but have remained relatively constant between 1995 and 2005 (Figure H). 14

The estimated number of initial visits to physicians’ offices for PID from the National Disease and Therapeutic Index (NDTI) has generally declined from 1993 through 2006 (Figure I and Table 42).

In 2004, an estimated 170,076 cases of PID were diagnosed in emergency departments among women 15 to 44 years of age. In 2005 this estimate decreased to 147,642 (National Hospital Ambulatory Medical Care Survey, NCHS). As of the date of publication of this report, 2006 data are not available.

Racial disparities in diagnosed PID have been observed in both ambulatory and hospitalized settings. Black women had rates of disease that were two to three times those in white women. Because of the subjective methods by which PID is diagnosed, racial disparity data should be interpreted with caution.15

Ectopic Pregnancy

Evidence suggests that health care practices associated with clinical management of ectopic pregnancy changed in the late 1980s and early 1990s. Before that time, treatment of ectopic pregnancy usually required admission to a hospital. Hospitalization statistics were therefore useful for monitoring trends in ectopic pregnancy. From 1996 to 2005, hospitalizations for ectopic pregnancy have remained generally stable (Figure G). As of the date of publication of this report, 2006 data are not available. Data suggest that nearly half of all ectopic pregnancies are treated on an outpatient basis.16

12 U.S. Department of Health and Human Services. Healthy People 2010. 2nd ed. With Understanding and Improving Health and Objectives for Improving Health. 2 vols. Washington, DC: U.S. Government Printing Office, November 2000.