Buehrle has been on the White Sox for his entire 11-year major league career. He has earned 161 wins, has a lifetime ERA of 3.83, and was one of the few members left of the 2005 team that won the World Series.

Buerhle is one of two White Sox pitchers in history to throw a perfect game, which he did on July 23, 2009 against Tampa Bay. He also threw a no-hitter on April 18, 2007 against Texas.