Differential Diagnosis

Other congenital coagulation disorders (particularly in LAD3 due to bleeding tendency)

Clinical Background

Leukocyte adhesion deficiency disorders (LAD) are a primary immune deficiency syndromes that affect the leucocyte adhesion process. There are three types of LAD – 1, 2, and 3. LAD1 is the most common type.

Epidemiology

Incidence/prevalence – rare

LAD1 – most common type

Age – usually identified in infancy or early childhood

Inheritance

At least 3 types identified

LAD1

Autosomal recessive

Mutation of CD18 gene (ITGB2) – defect in expression of common chain (CD18) of β2 integrin family