James Cameron has been developing the project for several years now, and he will continue to produce with his Lightstorm Entertainment partners Jon Landau and Rae Sanchini, with David S. Goyer set to executive produce. We reported in May 2014 that David S. Goyer was writing a new treatment for the project, and now he is set to co-write the script with Justin Rhodes (Contract Killers).

The original Fantastic Voyage hit theaters in 1966, centering on a team of scientists who are shrunk to atomic size and sent in a miniature submarine inside the body of a scientist to save his life. The movie was set during the Cold War, and the scientist was a defector who was in a coma after an assassination attempt. The original classic starred Stephen Boyd, Raquel Welch, Edmond O'Brien and Donald Pleasence.