On January 4, 2013, Henry Esber, Ph.D. tendered his resignation as a member of
the board of directors (the Board) of Apricus Biosciences, Inc. (the Company), effective immediately. Dr. Esber did not serve on any committees of the Board at the time of his resignation. Dr. Esber resigned for
personal reasons and his resignation was not related to a disagreement with the Company.

2

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

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