DRUG DESCRIPTION

and whose molecular weight is 227.09. The organic nitrates
are vasodilators, active on both arteries and veins.

The Transderm-Nitro (nitroglycerin) transdermal system is a
flat unit designed to provide continuous controlled release of nitroglycerin
through intact skin.

The rate of release of nitroglycerin is linearly dependent
upon the area of the applied system; each cm² of applied system delivers approximately
0.02 mg of nitroglycerin per hour. Thus, the 5-, 10-, 20-, and 30-cm² systems deliver
approximately 0.1, 0.2, 0.4, and 0.6 mg of nitroglycerin per hour, respectively.

The remainder of the nitroglycerin in each system serves as
a reservoir and is not delivered in normal use. After 12 hours, for example, each
system has delivered 10% of its original content of nitroglycerin.

The Transderm-Nitro system comprises four layers as shown
below. Proceeding from the visible surface towards the surface attached to the
skin, these layers are: 1) a tan-colored backing layer (aluminized plastic) that is impermeable to
nitroglycerin; 2) a drug reservoir containing nitroglycerin adsorbed on lactose, colloidal
silicon dioxide, and silicone medical fluid; 3) an ethylene-vinyl acetate copolymer membrane that
is permeable to nitroglycerin; and 4) a layer of hypoallergenic silicone adhesive. Prior to
use, a protective peel strip is removed from the adhesive surface.

Cross section of the system

What are the possible side effects of nitroglycerin transdermal (Minitran, Nitrek, Nitro TD Patch-A, Nitro-Dur)?

Nitroglycerin transdermal can cause severe headaches, especially when you first start using it. These headaches may gradually become less severe as you continue to use nitroglycerin transdermal. Do not stop using the medication. Ask your doctor before using any headache pain medication.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

What are the precautions when taking nitroglycerin (Transderm Nitro)?

Before using this medication, tell your doctor or pharmacist if you are allergic to it; or to similar drugs (such as isosorbide mononitrate); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have a certain medical condition. Before using this medicine, consult your doctor or pharmacist if you have: recent head injury.