Deploy your vCenter Server as a VM. (Possibly into a separate "Management" cluster.)

Use vSphere features such as HA to keep it available through hardware failures.

Backup your vCenter Server well and backup often.

As we use more distributed and software defined features such as Virtual Distributed Switches, VSAN, NSX etc, the availability of our vCenter Servers is becoming increasingly important, though VMware has no plans to replace the product; "There are no immediate plans to introduce another product."