Both the acetylation and SUMOylation status of the PXR (show NR1I2 Antibodies) protein is affected by its ability to associate with the lysine de-acetylating enzyme HDAC3 (show HDAC3 Antibodies) in a complex with SMRT.

These studies support a model in which NCOR1 (show NCOR1 Antibodies)/2 mediates direct Retinoic acid-dependent repression of Fgf8 (show FGF8 Antibodies) in caudal (show CAD Antibodies) progenitors in order to control somitogenesis.

changes in dietary components can consistently, if moderately, modulate the total transcript levels and the mRNA splicing of NCoR (show NCOR1 Antibodies) and SMRT in both cultured cells and intact mice.

SMRT regulates glucocorticoid action in adipocytes.

While silencing mediator of retinoid and thyroid hormone receptor (show THRA Antibodies) played little role in TH-regulated pathways, when disrupted in combination with nuclear receptor corepressor, it greatly accentuated the synthesis and storage of hepatic lipid

HDAC3 (show HDAC3 Antibodies) enzyme activity is undetectable in mice bearing point mutations in the deacetylase-activating domain of both NCOR1 (show NCOR1 Antibodies) and SMRT.

Human Nuclear Receptor Corepressor 2 (NCOR2) interaction partners

IL-6 (show IL6 Antibodies)-mediated AR antagonism induced by cypermethrin is related to repress the recruitment of co-regulators SRC-1 (show SRC Antibodies) and SMRT to the AR in a ligand-independent manner

this study identifies NCOR2 as a new gene for FVC, indicating the importance of further research into the role of vitamin A intake/supplementation and its interactions with related genes in the regulation of FVC.

Molecular basis for the specific interactions between HDAC4 (show HDAC4 Antibodies) and the SMRT corepressor.

NCOR2 Antigen Profile

Antigen Summary

This gene encodes a nuclear receptor co-repressor that mediates transcriptional silencing of certain target genes. The encoded protein is a member of a family of thyroid hormone- and retinoic acid receptor-associated co-repressors. This protein acts as part of a multisubunit complex which includes histone deacetylases to modify chromatin structure that prevents basal transcriptional activity of target genes. Aberrant expression of this gene is associated with certain cancers. Alternate splicing results in multiple transcript variants encoding different isoforms.