2. Chemistry

Methylone (also known as "3,4-methylenedioxy-N-methylcathinone",
"MDMC", "βk-" and by the slang term "M1") is an empathogen and
stimulant psychoactive drug. It is a member of the substituted
amphetamine, substituted cathinone and substituted
methylenedioxyphenethylamine classes.

Methylone is the substituted cathinone analog of and the
3,4-methylenedioxy analog of methcathinone. The only structural
difference of methylone with respect to is the substitution of 2
hydrogen atoms by 1 oxygen atom in the β position of the
phenethylamine core, forming a ketone group.

Methylone was first synthesized by the chemists Peyton Jacob III
and Alexander Shulgin in 1996 for potential use as an
antidepressant.

Starting around 2004, methylone has been sold for recreational use,
taking advantage of the absence of legal prohibition of this
compound in many countries.

Ethylone acts as a mixed reuptake inhibitor/releasing agent of
serotonin, norepinephrine, and dopamine.These are the
neurotransmitters in charge of pleasure, reward, motivation and
focus.This is done by inhibiting the reuptake and reabsorption of the
neurotransmitters after they have performed their function of
transmitting a neural impulse, essentially allowing them to
accumulate and be reused, causing physically stimulating and
euphoric effects.

In comparison to methylone, it has approximately over 3x lower
affinity for the serotonin transporter (which itself has 3x lower
affinity than ), while its affinity for the norepinephrine and
dopamine transporters is similar.

The results of these differences in pharmacology relative to
methylone is that ethylone is less potent in terms of dose, has
more balanced catecholaminergic effects relative to serotonergic,
and behaves more like a reuptake inhibitor like methylphenidate
than a releaser like amphetamine; however, ethylone still has
relatively robust releasing capabilities.

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"Methylone" is also a trademarked brand name for an injectable form
of methylprednisolone, a corticosteroid hormone used to treat
arthritis and severe allergic reactions; hence, methylone may be
confused with it. Aside from context, they can be distinguished by
the fact that the name will usually be capitalized when referring
to the prescription drug.

A proposed alternate name is bk-, or beta-keto-. While this
nomenclature has not caught on because the name "methylone" became
widely used before the conflicting Methylone trademark was noticed,
the analogous names for related chemicals bkmdea and bkmbdb have
become the established names for those substances.