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Research Topic

PVT1 in Cancer

About this Research Topic

Cancer is currently the second most common cause of death worldwide and it is projected to become the most common cause of death in the near future based on current trends. Human chromosome 8q24 is a well-established region of genomic instability and cancer susceptibility. While poor in protein-coding genes, it is rich in non-coding genes. One non-protein coding gene located downstream of MYC at chromosome 8q24 is PVT1. The PVT1 non-protein coding gene has been implicated in very many cancers, including cervical cancer, bladder cancer, colorectal cancer, gastric cancer, hepatocellular carcinoma, lung cancer, breast cancer, ovarian cancer, acute myeloid leukemia and Hodgkin’s lymphoma. It encodes six annotated microRNAs (miR-1204, miR-1205, miR-1206, miR-1207-3p, miR-1207-5-p, and miR-1208), some of which are also being implicated in carcinogenesis. Thus, PVT1 is emerging as a major player in cancer. This article collection will compile in one location the most recent and up to date information on the emerging role of PVT1 in various cancers.

Although articles covering any cancer will be considered, we especially welcome articles of all types that feature any of the following themes:

Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Cancer is currently the second most common cause of death worldwide and it is projected to become the most common cause of death in the near future based on current trends. Human chromosome 8q24 is a well-established region of genomic instability and cancer susceptibility. While poor in protein-coding genes, it is rich in non-coding genes. One non-protein coding gene located downstream of MYC at chromosome 8q24 is PVT1. The PVT1 non-protein coding gene has been implicated in very many cancers, including cervical cancer, bladder cancer, colorectal cancer, gastric cancer, hepatocellular carcinoma, lung cancer, breast cancer, ovarian cancer, acute myeloid leukemia and Hodgkin’s lymphoma. It encodes six annotated microRNAs (miR-1204, miR-1205, miR-1206, miR-1207-3p, miR-1207-5-p, and miR-1208), some of which are also being implicated in carcinogenesis. Thus, PVT1 is emerging as a major player in cancer. This article collection will compile in one location the most recent and up to date information on the emerging role of PVT1 in various cancers.

Although articles covering any cancer will be considered, we especially welcome articles of all types that feature any of the following themes:

Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author.