The full content of Annals is available to subscribers

Abstract

The localized atrophy of subcutaneous fat following repeated injections of insulin was first described by Depisch1 in 1926, and since then has been reported by Barborka,2 Davison,3 Mentzer and DuBray,4 Carmichal and Graham,5 Chapman,6 Rabinowitch,7,11 Lawrence,8 Priesel and Wagner,9,17 Avery,10 Fischer,12 McCormick and Moorhead,13 Stransky,14 Price,16 Boller,18 Eeg-Olofsson,19 and Williams.21 Less than sixty cases are recorded in the literature, and of these, less than half are described even briefly, and only two biopsy reports are given.

The atrophy noted was almost always at sites of frequent insulin injections and began several months to several years after starting the injections of