Electrophysiology studies of the brain allow us to study the dynamics of the cortex as subjects perform tasks and experiment. Of particular interest in human studies is the activity that occurs in motor related areas of ...

When performed by professional medical staff, cardiopulimary resuscitation (CPR) is successful in resuscitating patients in less than 45% of cases. Even in cases where patients survive, brain damage due to partially hypoxic ...

This dissertation focuses on the design and development of SPR-imaging microfluidic assays to quantify nanomolar concentrations of small molecules (cortisol and phenytoin) in saliva for a point-of-care medical diagnostic. ...

The diffusion immunoassay (DIA) is a novel assay technique based on the difference in diffusivity of an analyte molecule when free in solution, versus when it is bound to a cognate antibody. It is uniquely enabled by the ...

High specificity recognition proteins, like antibodies, are important biological tools with many applications, including diagnostics, therapeutics, and imaging. However, there are many challenges with antibody recognition ...

Microcirculation refers to the functions of capillaries and the neighboring lymphatic vessels. It plays a vital role in the pathophysiology of disorders in many clinical areas including cardiology, dermatology, neurology ...

Microcirculation refers to the functions of capillaries and the neighboring lymphatic vessels. It plays a vital role in the pathophysiology of disorders in many clinical areas including cardiology, dermatology, neurology ...

Artemisinin generates cytotoxic free radicals when it reacts with ferrous iron, and induces molecular damages and apoptosis in cells. Its toxicity is more selective toward cancer cells because cancer cells contain a higher ...

Current newborn screening programs for phenylketonuria (PKU) do not reach many individuals, worldwide, who would benefit from testing. Existing PKU tests require a high-resource laboratory, as well as a base level of local ...

Ischemic injury is caused by blockage or rupture of a blood vessel supplying an organ with oxygen and nutrients. A reduction of blood flow in the brain below critical values leads to a series of metabolic, functional, and ...

There is a growing need for sensitive, simple, affordable and rapid detection of infectious disease biomarkers for faster access to test results and improved patient outcomes. The development of rapid, portable and accurate ...

The development of paper-based diagnostics has surged in recent years, due to the suitability of these tests for use at the point of care. Paper-based diagnostics offer the ability to perform relatively sophisticated ...

Diseases of the central nervous system are largely untreatable, with most current treatment strategies palliative. Current therapeutic strategies are limited by drugs of low potency, poor pharmacokinetics, and poor ...

The incidence of esophageal adenocarcinoma has been rising in the western world with a low 5 year survival rate of less than 15%, but it can be treated when diagnosed early. However, conventional white light endoscopy ...

The time-varying states of atomic contacts reflect the dynamics of the protein. Protein dynamics are linked to protein functions. Thus, it is crucial to have automatic methods for extracting the relationships between atomic ...

The protein folding problem, the aim to understand how a protein’s amino acid sequence alone is sufficient to dictate its folded structure in a given environment, has confounded scientists for decades. Comprehensive ...

Prion diseases are fatal, transmissible and incurable neurodegenerative diseases that only infect mammals. While the manifestation of prion disease is not completely understood, it is known that the prion protein (PrP) ...

Catheterization is a common procedure used to relieve excess pressure in the brain during cases of hydrocephalus. However, the vast majority of catheterizations are guided using only external anatomical landmarks for ...