An approach has been made to the problem of how the synthesis of coenzymes is regulated. Two aspects of the problem have been studied, especially as they concern the synthesis of flavins by bacteria: (1) How are coenzymes prevented from being synthesized as fast as amino acids or nucleic acid bases? (2) How is coenzyme synthesis adjusted to the often changing physiological needs of bacteria? Evidence is presented that flavins cannot inhibit the activity of enzymes in the flavin biosynthetic… CONTINUE READING