With traditional screening designs, correlated main effects and confounded two-factor interactions often lead to costly follow-up runs. Definitive screening provides a way to avoid model ambiguity due to confounding and identify important factors more quickly.

Definitive screening designs offer the following advantages:

• For continuous factors, the number of required runs is only one more than twice the number of factors. Categorical factors require two more than twice the number of factors.

• Unlike resolution III designs, main effects are completely independent of two-factor interactions. As a result, estimates of main effects are not biased by the presence of active two-factor interactions, regardless ...

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