Moon was born in San Jose, California. She was raised in Connecticut and after graduating from high school when she was 17, Moon moved back to California. Afterwards, she moved between homes in both states to attend school and seek work. On October 31, 2002 she married long time boyfriend Robert Cummings (more well known as Rob Zombie) after almost 13 years of dating. The two had met at Toad's Place, a concert venue, in New Haven, Connecticut through mutual friends. Ten days before their planned wedding date, the couple decided to elope and get married on Halloween.

Sheri Moon Zombie career

Moon had aspirations to do cartoon voiceovers, taking classes as well, and briefly attended the Connecticut School of Broadcasting to become an MTV VJ "when it was cool, not totally plastic and mainstream like it is now". But Moon found herself preoccupied going on tour with Zombie. When Zombie's band White Zombie disbanded, Zombie began as a solo artist, taking Moon on as a dancer as well as choreographing and creating costumes for the tour.

Moon has appeared in eleven of Zombie's solo music videos and an additional four previous to that when he fronted White Zombie. She most famously starred in the Cabinet of Dr. Caligari-themed music video "Living Dead Girl". Moon has graced the cover of the single for "Living Dead Girl" (1998), Zombie's remix album American Made Music to Strip By (1999), and the cover of the single for "Demon Speeding". Aside from Zombie's work, she also appeared in Black Label Society's video for "Stillborn" and Prong's video for "Rude Awakening".

In 2002, Moon co-starred in her husband's first feature film, House of 1000 Corpses as Vera-Ellen "Baby" Firefly, but previous to that, she claims that she had never had aspirations of becoming an actress. As Sheri explains her character in that film, "Baby is the angelic-looking bait to get the victims." Moon starred alongside genre actors Sid Haig, Bill Moseley and Karen Black. The film was not received well by many critics, including James Brundage of popular website Filmcritic who claimed that it was "too highbrow to be a good cheap horror movie, too lowbrow to be satire, and too boring to bear the value of the ticket." The film saw some expansion in later weeks and ultimately grossed $16.8 million worldwide, which was successful based on its $7 million production budget.

In 2004, she had a brief appearance in the Tobe Hooper film Toolbox Murders starring Angela Bettis, the only film she has been in not directed by Zombie.

Moon reprises her role as Baby Firefly in The Devil's Rejects which won her "Best Villain" and "Best Duo" at the Spike TV Scream Awards and Fuse/Fangoria Awards respectively.Moon reprised her role as Baby Firefly in the 2005 sequel to House of 1000 Corpses, titled The Devil's Rejects. The Devil's Rejects was financially successful, recouping its roughly $7 million budget during its opening weekend, going on to earn over $16 million and better received by critics than its predecessor. Critic Roger Ebert gave the film three out of a possible four stars. Ebert wrote, "If you are a hardened horror movie fan capable of appreciating skill and wit in the service of the deliberately disgusting, 'The Devil's Rejects' may exercise a certain strange charm." Moon was awarded Spike TV's Scream Awards award for "Most Vile Villain" along side co-stars Haig, Moseley and Leslie Easterbrook for their portrayal of the Firefly family. Following that, she was awarded a Fuse/Fangoria Chainsaw Award for best duo with her co-star Moseley.

She appeared in the December 2005 issue of Playboy.

Moon designed a clothing line, Total Skull, which debuted at the end of May 2006. She explains, "The phrase "total skull" to me means awesome, rad the best of the best." Total Skull can be bought through the online store, at Hot Topic stores, various locations around the U.S. including Hollywood and Las Vegas, and two store locations in Australia.

In 2007, Moon starred in a short faux trailer segment for the film Grindhouse. She appeared in the segment directed by Zombie titled Werewolf Women of the SS as Eva Krupp. She also appeared in her husband's version of the 1978 classic Halloween, playing Deborah Myers, the mother of Michael Myers. It currently stands as the third highest grossing overall film in the Halloween franchise. Despite the commercial success of the film, Moon has no intention to appear in another Halloween film.

Moon provides the voice for the character of Susie X in the upcoming animated film The Haunted World of El Superbeasto, written and produced by her husband Zombie. The film is still in production with no release date yet set.