Pepcid Injection

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Pepcid Injection

OVERDOSE

The adverse reactions in overdose cases are similar to the adverse reactions
encountered in normal clinical experience (see ADVERSE
REACTIONS). Oral doses of up to 640 mg/day have been given to adult
patients with pathological hypersecretory conditions with no serious adverse
effects. In the event of overdosage, treatment should be symptomatic and supportive.
Unabsorbed material should be removed from the gastrointestinal tract, the patient
should be monitored, and supportive therapy should be employed.

The intravenous LD50 of famotidine for mice and rats ranged from 254-563 mg/kg and the minimum lethal single I.V. dose in dogs was approximately 300 mg/kg. Signs of acute intoxication in I.V. treated dogs were emesis, restlessness, pallor of mucous membranes or redness of mouth and ears, hypotension, tachycardia and collapse. The oral LD50 of famotidine in male and female rats and mice was greater than 3000 mg/kg and the minimum lethal acute oral dose in dogs exceeded 2000 mg/kg. Famotidine did not produce overt effects at high oral doses in mice, rats, cats and dogs, but induced significant anorexia and growth depression in rabbits starting with 200 mg/kg/day orally.

CONTRAINDICATIONS

Hypersensitivity to any component of these products. Cross sensitivity in this
class of compounds has been observed. Therefore, PEPCID should not be administered
to patients with a history of hypersensitivity to other H2-receptor antagonists.

Last reviewed on RxList: 11/30/2007
This monograph has been modified to include the generic and brand name in many instances.