9 Graft failure and patient’s death in the first year after transplantation 1984-2002198519861987198819891990199119921993199419951996199719981999200020012002Transplant year51015202530PercentatgeGraft failureDeathRMR Catalunya

21 Cardiovascular mortality in renal transplant recipients1010.10.010.001Annual mortality (%)Renal transplant recipientsGeneral populationData on renal transplant patients from the US Renal Data System (USRDS) have shown that renal transplant patients have a higher risk of mortality compared to the general population.This risk increases with the age of the recipient, but the risk should not be underestimated in younger patients.Compared with the general population, cardiovascular mortality in transplant patients is increased almost 10-times between the ages of 35 and 44 years and is at least doubled between the ages of 55 and 64 years.Reference:Foley RN, Parfrey PS, Samak MJ. Cardiovascular disease in chronic renal disease. Clinical epidemiology of cardiovascular disease in chronic renal disease. Am J Kidney Dis 1998;32(Suppl. 3):S112–1925–34 35–44 45–54 55–64 65–74 75–84Age (years)Reproduced from Foley RN, et al. Am J Kidney Dis 1998;32(Suppl. 3):112–19

29 Renal dysfunction is a strong risk factor for cardiovascular death3.0CV death with a functioning graft*p<0.052.52.26*2.01.67*1.49*1.51.37*RR1.19*1.031.001.00.5An analysis on 58,900 kidney adult patients registered in the USRDS database was performed.All patients received a primary renal transplant between 1988 and 1998 and had at least one year of graft survivalSerum creatinine values at 1 year after transplantation were strongly associated with the risk for cardiovascular death.Reference:Meier-Kriesche HU, Baliga R, Kaplan B. Decreased renal function is a strong risk factor for cardiovascular death after renal transplantation. Transplantation 2003;75:<1.3Serum creatinine (mg/dL)Adapted from Meier-Kriesche HU, et al. Transplantation 2003;75:1291–5