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For example, we know that levels of a protein called TNF-alpha are elevated in active MS and that drugs that block TNF-alpha are helpful in rheumatoid arthritis. However, drugs to block TNF-alpha actually made MS worse in clinical trials.

Are there any vaso-constricting characteristics of this drug? and how long did it take to get this trial up and running?

Are CCSVI and MS related?Many people hope that CCSVI will prove to be the cause of MS but, at present, this idea isnot supported by fact. Furthermore, it does not seem likely that MS causes CCSVI.

further down..

If proven, the association between MS and CCSVI may actually be explained by MS causing CCSVI. The Inflammatory proteins related to MS travel through the major veins draining the brain, and may cause the veins to simply show changes consistent with inflammatory cell contact. In the Buffalo study, a higher frequency of CCSVI was seen in MS patients with more severe disease; this is most consistent with MS causing CCSVI.

?? contradictory and confusing??

Last edited by PCakes on Mon Oct 18, 2010 7:32 am, edited 1 time in total.

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The article emphasizes "dangerous" risks with procedures and talks about AHS discouraging all ms sufferers from going out of the country to have it done. I had lunch with Neil Pierce mentioned in this article about 6 weeks ago. They want me to be part of their advisory committee ...hmmmm . I found out preliminary results yesterday from the Hubbard foundation. I will get the final results from Dr.Haake soon. The results showed significant reflux in both jugulars-enough to initiate a referral to an I.R. This could be a valuable experience for me if I ever do get involved with our local MS society.

CCSVI and MS may be related. Current information from Buffalo suggests that people with MS have a 56.4% chance of having CCSVI, and that those without MS have a 22.4% chance. In addition, over 40% of people with other neurological diseases have vascular changes consistent with CCSVI.

Of course that 56 goes up to 62 when you eliminate borderlines.By quoting the lower number you are showing your opinions in this discussion.

The Buffalo study is in quesion because of their extensive use of ultrasound and mri. Venography is the gold standard.

However, other groups (Doepp et al, 2010 Annals of Neurology) have not found an increased rate of CCSVI in British and German people with MS as compared to “control” persons without MS

In contrast, Dr. Zamboni reported that 100% of the MS patients he studied had MS but none of his controls had CCSVI. While the final answer is not clear, anyone following CCSVI through the social media knows that many people with MS do not have the imaging changes that define the syndrome.

I think zamboni is now finding around 12%? Other sites are reporting 14%

As we go my key arguement is "CCSVI is truncular. 40 vascular experts agreed. Lots of patients have bone involvement. I really like your paper because it clearly states the other logic. Breaking down that logic using science is all Im trying to do.

If proven, the association between MS and CCSVI may actually be explained by MS causing CCSVI. The Inflammatory proteins related to MS travel through the major veins draining the brain, and may cause the veins to simply show changes consistent with inflammatory cell contact. In the Buffalo study, a higher frequency of CCSVI was seen in MS patients with more severe disease; this is most consistent with MS causing CCSVI.

So I guess you didn't mean it when you said

Furthermore, it does not seem likely that MS causes CCSVI.

This mistake is a good sign. It shows you just sat down at a typewriter and wrote off the cuff. We need that from 'the other side'. Thank you.

For me causation comes down to putnam, and whether his work from 1936 will be replicated at stanford. If occlusions in jugular veins cause enephalomyelitus then we know the venous theory of ms is true. If not, we lose.

Last edited by Billmeik on Sat Aug 07, 2010 7:35 am, edited 2 times in total.

Patients experience ms symptoms when their veins close up. All over the world in dozens of cases. I know ignoring this is the official way but if you think of all these people as lab rats, restenosis can prove causation.

Such a poorly written paper.. am i biased, yes, but setting that aside the contradictions (highlighted by myself and billmeik) along with the scare tactics makes this painful to read.
I find this to be a blatant misuse of power and trust. There are still many msers counting on the MS society and Health Canada for information.
I wonder if the author(s) will come forward?

How could MS actually cause CCSVI?We know from many studies that signals within the brain attract inflammatory cells from the circulation. This causes these inflammatory cells to stick to the small blood vessels in the brain.These cells do not get stuck in the vessels due to blocked flow; instead, they become attached to the vessels because molecules called “integrins” on the inflammatory cells exactly match molecules on the vessel wall (“integrin receptors”) like a key in a lock. Once bound to the vessel the inflammatory cells can then pass into the brain.

It is good to hear this put into words. Lots of docs have been saying it but is there a chance that ccsvi is a build up of scar tissue? Is stenosis somehow caused by brain lesions?

Yes. I want to know. On with the tests and the probing of ccsvi causation.

btw assuming the former was the case, is there still an arguement towards
clearing the blockages for therapeutic reasons? Perhaps...

This is where I go onto a system's comparison of my pick up truck and how it stopped running because of a clog in the catalytic. The tail pipe got blocked and so the engine stopped. The output had ccsvi and that caused the central processor to fail.

I think maybe causes of CCSVI are within modern research's grasp. It will not be necessary for anyone to rub salt in the wound, and say why congenital venous abnormalities can't be caused by MS. But applying a fraction of the research and sacrifice of animals should give us an idea where it comes from. It could be fetal alcohol, or fetal smoking...maybe lead or strontium 90? I figure genes are a good start.

Zamboni clains MS is caused by a buildup of iron deposits in the veins leading to the brain. He further claims that unblocking the veins, using balloon angioplasty and stents, improved cranial blood flow and improved range of movement in MS patients.

Avis Favarro had the facts alot more accurate back with the original news story. Who is adding such garbage info into the mix, why is there coverage of bad study results...where is the open and honest look at this? Why would the MSS write the gov to tell them to ignore CCSVI unless they say to look at it...why did Yves say he doesn't know about a world recognized phlebology organization...and that he could support a pharmacological treatment for CCSVI...???
Sure is hard to feel things are being presented without a bias.

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