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Her exit followed her best friend Fearne, 38, stepping down from the Keith Lemon-fronted series herself two years ago.

Taking to Instagram, Holly posted a long statement about why she was leaving as she shared some memories from her time on the show.

And while Fearne is yet to say much about Holly following in her footsteps, she commented on the Instagram post to voice her support for Holly.

Holly Willoughby and Fearne Cotton were the original team captains on Celebrity Juice (Image: ITV)

Holly and Fearne are very close (Image: fearnecotton/Instagram)

She posted a string of love heart emojis in solidarity.

Fearne decided to leave the show in 2018 as her career started taking a different turn as she focused on her wellness brand.

Holly had written: "Thank you @celebjuiceofficial for 12 years of fantastic chaos... I can't quite believe what we’ve done and how quick that time has gone. Thank you to you all for watching, we’ve always had the loudest and best audiences.

Holly has spent 12 years on the late-night quiz (Image: ITV)

"Also a huge thank you to @itv2 for believing in the show in the first place and for all of your support...Over the years the production team has changed, however to anyone lucky enough to have worked on the show they will know that we really do have the best time, it’s never felt like work and always been to me like a night out.

"Thank you for all your ingenious ideas and hard work... all good things must come to an end and nothing lasts forever."

Celebrity Juice host Keith has also commented on the news.

Fearne left the show in 2018 (Image: ITV)

He posted: "I've had a lovely time working with you. You are the best! I hope I'm lucky enough to work with you again one day. Goodbye @hollywills x."