SCIENTIFIC ADVISORS
Leonard Hayflick,
Ph.D.Professor of Anatomy University of
California, San Francisco

Relationship to the Project:Dr.
Hayflick, best known for the Hayflick Limit showing that cultured
normal cells have a limited capacity for replication, wrote the
popular book, “How and Why We Age”, in August 1994. Mr. Guerin read
the book with interest a year later. He especially noted the chapter
entitled “Some Animals Age, Some Do Not”. It was the first time Mr.
Guerin had read this information from a scientific source, although
later he came across detailed information on this phenomenon coined
“negligible senescence” by Caleb Finch at USC. Mr. Guerin started
the project that came to be known as the Centenarian Species and
Rockfish Project in August 1995 as a result of this
information.

Later on in 1995 the Director met Dr. Hayflick
at a Gerontological Society of America meeting. Mr. Guerin told him
of his background in Project Management, and his interest in
assisting research in this area. He asked Dr. Hayflick who was
researching these long-lived animals, and the reply was “Nobody is,
but they should be!” From this point forward Dr. Hayflick has served
as a Scientific Advisor to this project. His biography is
below

Research
area:the role and causes of all
the accumulating and eventually pathogenic molecular and cellular
side-effects of metabolism that constitute mammalian aging; the
design of interventions to reverse and/or obviate this
accumulation.

Bio
paragraph (e.g., if you have invited me to speak and are creating
promotional material):

Dr. Aubrey de Grey
is a biomedical gerontologist based in Cambridge, UK and Mountain
View, California, USA, and is the Chief Science Officer of SENS
Research Foundation, a California-based 501(c)(3) charity dedicated to
combating the aging process. He is also Editor-in-Chief of Rejuvenation Research, the
world’s highest-impact peer-reviewed journal focused on intervention
in aging. He received his BA and Ph.D. from the University of
Cambridge in 1985 and 2000 respectively. His original field was
computer science, and he did research in the private sector for six
years in the area of software verification before switching to
biogerontology in the mid-1990s. His research interests encompass
the characterisation of all the
accumulating and eventually pathogenic molecular and cellular
side-effects of metabolism (“damage”) that constitute mammalian
aging and the design of interventions to repair and/or obviate that
damage. He has developed a possibly comprehensive plan for such
repair, termed Strategies for Engineered Negligible Senescence
(SENS), which breaks aging down into seven major classes of damage
and identifies detailed approaches to addressing each one. A key
aspect of SENS is that it can potentially extend healthy lifespan
without limit, even though these repair processes will probably
never be perfect, as the repair only needs to approach perfection
rapidly enough to keep the overall level of damage below pathogenic
levels. Dr. de Grey has termed this required rate of improvement of
repair therapies “longevity escape velocity”. Dr. de Grey is a
Fellow of both the Gerontological Society of America and the
American Aging Association, and sits on the editorial and scientific
advisory boards of numerous journals and organisations.

de Grey ADNJ.
Making sure that health and wealth keep pace with extended life
expectancy. United Academics Magazine 2012; 2012(April/May):
http://www.united-academics.org/magazine/17748/making-sure-that-health-and-wealth-keep-pace-with-extended-life-expectancy/

de Grey ADNJ.
Zeno’s paradox and the faith that technological game-changers are
impossible. Gerontology 2012, in press.

de Grey ADNJ. An
engineer’s approach to the development of real anti-aging medicine.
In: The Fountain of Youth: Ethical, Religious, and Existential
Perspectives on a Biomedical Goal (S.G. Post and R.H. Binstock,
eds.), Oxford University Press, 2004, pp. 249-267.

de Grey ADNJ. Physical resilience and aging: correcting
the Tithonus error and the crème brulée error. In: New Frontiers of
Resilient Aging: Life-Strengths and Well-Being in Late Life (P.S.
Fry and C.L.M. Keyes, eds.), 2010, pp.
90-103.

de Grey ADNJ.
Living to 100 and maybe much longer: the engineering and
biotechnology of life-extension medicine and when it may arrive. In:
Proceedings of the 6th International Conference on
Intelligent Processing and Manufacturing of Materials, (J.A. Meech,
ed.), 2012, in press.