What is glimepiride and rosiglitazone (Avandaryl)?

Glimepiride and rosiglitazone is a combination of two oral diabetes medicines that help control blood sugar levels.

Glimepiride and rosiglitazone is for people with type 2 diabetes. This medication is not for treating type 1 diabetes. Glimepiride and rosiglitazone is not recommended for use with insulin.

Taking glimepiride and rosiglitazone may increase your risk of serious heart problems, such as heart attack or stroke. Therefore, glimepiride and rosiglitazone is available only to certain people with type 2 diabetes that cannot be controlled with other diabetes medications.

Glimepiride and rosiglitazone is available only under a special program called Avandia-Rosiglitazone Medicines Access Program. You must be registered in the program and sign documents stating that you understand the risks and benefits of taking this medication.

Glimepiride and rosiglitazone may also be used for purposes not listed in this medication guide.

Avandaryl 1 mg-4 mg

triangular, yellow, imprinted with gsk, 4/1

Avandaryl 2 mg-4 mg

triangular, orange, imprinted with gsk, 4/2

Avandaryl 4mg-4 mg

triangular, pink, imprinted with gsk, 4/4

What are the possible side effects of glimepiride and rosiglitazone (Avandaryl)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

What is the most important information I should know about glimepiride and rosiglitazone (Avandaryl)?

Taking glimepiride and rosiglitazone may increase your risk of serious heart problems, such as heart attack or stroke. Therefore, glimepiride and rosiglitazone is available only to certain people with type 2 diabetes that cannot be controlled with other diabetes medications.

Do not use glimepiride and rosiglitazone if you have type 1 diabetes, or if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin).

Before taking glimepiride and rosiglitazone, tell your doctor if you have congestive heart failure or heart disease, a history of heart attack or stroke, liver or kidney disease, an enzyme deficiency called G6PD, adrenal or pituitary gland disorders, or eye problems caused by diabetes.

Women may be more likely than men to have bone fractures in the upper arm, hand, or foot while taking glimepiride and rosiglitazone. Talk with your doctor if you are concerned about this possibility.