Telomeres are closely involved in stem cell differentiation and cancer cell proliferation. Our long-term goal is to reveal new mechanisms for telomere length regulation and chromosome end protection. Therefore, valuable targets for mechanism-driven design of cancer and anti-aging therapeutics may be identified through our research. Specifically, we are interested in:

• Regulation of telomere homeostasis from atomic level to system level using the integration of biochemistry, structural biology (especially, x-ray crystallography), and genetics approaches.