Amelogenesis imperfecta (AI) is a developmental disorder of genomic origin associated with structural enamel formation. Hereditary brown enamel, hereditary enamel dysplasia, hereditary brown opalescent teeth are the other terminologies used for AI. The prevalence varies from 1:700 to 1:14 000, according to the populations studied. AI affects the entire ectodermal component and the enamel may be hypoplastic, hypomineralized or both and affected teeth may be esthetically and functionally compromised, discolored, sensitive or prone to disintegration, leading to loss of occlusal vertical dimensions and very poor aesthetics. Although AI is considered as a single disease entity, it actually represents a group of heterogenous conditions, with diverse structural defects of enamel resulting in a range of clinical phenotypes. It is characterized by clinical and genetic heterogeneity in the absence of systemic abnormalities or diseases. AI had been found to be associated with non-enamel anomalies such as delayed eruption, crown resorption, congenitally missing teeth, pulpal calcifications, dental follicular hamartomas, and gingival hyperplasia. Mutations in the amelogenin, enamelin, and kallikrein-4 genes have been demonstrated to different types of AI.Restoration of the dentition poses a great challenge when all the teeth are severely affected. The treatment opportunities for these patients may help in refining their lifestyle. This case report reviews a holistic multidisciplinary treatment approach for the oral rehabilitation of patient with hypoplastic AI with multiple impacted teeth.