Anti-Human Parkin Mouse IgG MoAb

Parkin is encoded by the PARK2 gene in humans; its precise function is unknown. However, it is known to be part of a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. The ubiquitin-tagged proteins are then degraded by ubiquitin-proteasome complexes. Mutations in the PARK2 gene are associated with familial and autosomal recessive juvenile forms of Parkinson disease. It has been suggested that loss of function of the parkin protein leads to dopaminergic cell death, but the mechanism is not clear. Parkin is also known as Parkinson protein 2, E3 ubiquitin protein ligase; Parkinson disease (autosomal recessive, juvenile) 2, parkin; E3 ubiquitin-protein ligase parkin, Parkinson disease protein 2, PDJ, PRKN, AR-JP, and LPRS2.

These products are affinity-purified IgG antibodies that recognize human parkin protein. The antibodies were raised in mouse using synthetic peptides and can be used for Western blot (WB) detection, immunohistochemical (IHC) detection, immunocytochemical (ICC) detection, or immunoprecipitation (IP) of human parkin protein.