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Abstract

Several compounds that exhibit a therapeutic effect in experimental models of neurodegenerative diseases have been identified over recent years. Safe and effective drug delivery to the central nervous system is still one of the main obstacles in translating these experimental strategies into clinical therapies. Different approaches have been developed to enable drug delivery in close proximity to the desired site of action. In this review, we describe biodegradable polymeric systems as drug carriers in models of neurodegenerative diseases. Biomaterials described for intracerebral drug delivery are well tolerated by the host tissue and do not exhibit cytotoxic, immunologic, carcinogenic or teratogenic effects even after chronic exposure. Behavioral improvement and normalization of brain morphology have been observed following treatment using such biomaterials in animal models of Parkinson's, Alzheimer's and Huntington's diseases. Application of these devices for neuroactive drugs is still restricted due to the relatively small volume of tissue exposed to active compound. Further development of polymeric drug delivery systems will require that larger volumes of brain tissue are targeted, with a controlled and sustained drug release that is carefully controlled so it does not cause damage to the surrounding tissue.

TY - JOUR
T1 - Therapeutic potential of controlled drug delivery systems in neurodegenerative diseases.
AU - Popovic,N,
AU - Brundin,P,
Y1 - 2006/03/10/
PY - 2005/07/01/received
PY - 2005/09/09/accepted
PY - 2006/3/15/pubmed
PY - 2007/8/7/medline
PY - 2006/3/15/entrez
SP - 120
EP - 6
JF - International journal of pharmaceutics
JO - Int J Pharm
VL - 314
IS - 2
N2 - Several compounds that exhibit a therapeutic effect in experimental models of neurodegenerative diseases have been identified over recent years. Safe and effective drug delivery to the central nervous system is still one of the main obstacles in translating these experimental strategies into clinical therapies. Different approaches have been developed to enable drug delivery in close proximity to the desired site of action. In this review, we describe biodegradable polymeric systems as drug carriers in models of neurodegenerative diseases. Biomaterials described for intracerebral drug delivery are well tolerated by the host tissue and do not exhibit cytotoxic, immunologic, carcinogenic or teratogenic effects even after chronic exposure. Behavioral improvement and normalization of brain morphology have been observed following treatment using such biomaterials in animal models of Parkinson's, Alzheimer's and Huntington's diseases. Application of these devices for neuroactive drugs is still restricted due to the relatively small volume of tissue exposed to active compound. Further development of polymeric drug delivery systems will require that larger volumes of brain tissue are targeted, with a controlled and sustained drug release that is carefully controlled so it does not cause damage to the surrounding tissue.
SN - 0378-5173
UR - https://www.unboundmedicine.com/medline/citation/16529886/Therapeutic_potential_of_controlled_drug_delivery_systems_in_neurodegenerative_diseases_
L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-5173(06)00092-5
DB - PRIME
DP - Unbound Medicine
ER -