Examine proteomic concentrations of inflammatory proteins and neuropeptides following TBI and determine if these biomarkers relate to a greater risk for PTSD, depression or PCS.

We will investigate the activation and effective connectivity between the amygdala and other target regions regulating emotions by analyzing fMRI data to determine neuronal mechanisms related to PTSD, PCS, and depression onset.

Examine epigenetic modifications (i.e. DNA methylation) and genetic predisposition using blood and saliva that may relate to the risk for PTSD, depression and PCS onset following a TBI.

120

All

18 Years to 65 Years (Adult, Older Adult)

NCT02019654

14003214-NR-0032

December 20, 2013

July 1, 2019

July 1, 2019

December 24, 2013

August 9, 2018

George Washington UniversityWashington, District of Columbia, United States

National Institutes of Health Clinical Center, 9000 Rockville PikeBethesda, Maryland, United States

The primary objective of this study is to determine whether strengthening activity in the dlPFC with TMS will reduce anxiety either alone (during NPU) or during a low load cognitive task(Sternberg WM).

184

All

18 Years to 50 Years (Adult)

NCT03027414

17004217-M-0042

January 12, 2017

January 1, 2023

January 1, 2023

January 23, 2017

August 9, 2018

National Institutes of Health Clinical CenterBethesda, Maryland, United States

MTD of palbociclib isethionate defined as the highest dose level at which six patients have been treated with at most one patient experiencing a dose limiting toxicity and the next higher dose level has been determined to be too toxic

Incidence of adverse events

Objective responses (partial response + complete response)

(and 2 more...)

55

All

4 Years to 21 Years (Child, Adult)

NCT02255461

PBTC-042U01CA081457

October 2014

December 31, 2018

December 31, 2018

October 2, 2014

September 28, 2017

Childrens Hospital Los AngelesLos Angeles, California, United States

Lucile Packard Children Hospital Stanford UniversityPalo Alto, California, United States

Childrens National Medical CenterWashington, D.C., District of Columbia, United States

Measure AAD and ADD, compute white matter pathway trajectories using diffusion MRI and MAP-MRI data, use resting-state functional MRI to identify salient cortical regions in which many of these tracts terminate.

40

All

18 Years to 70 Years (Adult, Older Adult)

NCT03223636

17012817-N-0128

October 2, 2017

December 31, 2018

December 31, 2019

July 21, 2017

June 29, 2018

National Institutes of Health Clinical CenterBethesda, Maryland, United States

Relationship between health status and disease and treatment characteristics as well as clinicaL and demographic risk factors as self reported by adult participants with rare CNS tumors; and the relationship of genomic susceptibility of the popu...

Correlation between intensity of in vivo fluorescence and the pathologist's quantification of tumor in biopsy specimens (e.g., percentage of tumor present) as measured by PpIX concentration and intra-operative fluorescence intensity

Correlation between the amount and location of residual tumor detected intraoperatively by fluorescence imaging and frameless stereotaxy after maximal resection and the post-operative image enhancement on CT scan and/or MRI