9 Facts You Probably Didn’t Know About Infertility and IVF

Learning about “the birds and the bees” may be the way your parents described getting pregnant but it’s a lot more complicated than you think. And for many couples, trying to have a baby is a result of science and technology that has come a long way in a relatively short amount of time.

In 2015, 3,978,497 babies were born in the US and 5.1 million babies in the European Union.

Infertility

According to the CDC around 1 million married couples in the US have had difficulty getting pregnant after one year of trying. If a couple under the age of 35 is having trouble getting pregnant after a year of frequent sex, it is recommended that they see a physician about it. If a couple is over 35, they should see a physician after six months of trying.

Issues causing female infertility

Women can have problems with their ovaries which interfere with getting pregnant. Polycystic ovary syndrome is the most common cause. Diminished ovarian reserve is another common problem. Diminished ovarian reserve refers to the fact that females are born with all the eggs they will ever have– between 1 and 2 million. By the time of menstruation, that number is about 300,000. Eggs are released with every menstruation. As women age, fewer and fewer eggs are available for fertilization.

Women can also suffer from endometriosis, a condition in which tissue from the inside of the uterus grows outside of the uterus. This tissue can block fallopian tubes and can cause scarring that interferes with fertility. Pelvic inflammatory disease, cervical stenosis (narrowing of the passage into the uterus) and fibroids or myomas in the uterus also hinder the ability to get pregnant.

Much of the problems had to do with understanding all the components of the process in vivo (in the body) in order to replicate it in the lab. For example, for conception to occur, an egg must be fertilized with 12 to 24 hours after the egg has left the ovary.

Here is a video which describes what happens in vivo (within the body) during fertilization.

https://youtu.be/_5OvgQW6FG4

Some of the difficulties in getting to that first child, Louise Joy Brown, included understanding capacitance in sperm. Capacitance is a maturing of the sperm, a chemical reaction that must take place so that there is increased mobility of the sperm. Additionally, the membrane covering the head of the sperm changes to allow penetration of the outer layers of the egg. The environment inside a woman’s body encourages capacitance.

Here are some success rates statistics available from 2014. These are ART cycles (a cycle is the process of stimulation of ovaries to produce mature eggs) using the woman’s own eggs that led to live births. It may take several cycles to collect enough eggs before attempting fertilization and transfer to the woman’s uterus.

“37% in women younger than 35 years of age.

30% in women aged 35 to 37 years.

20% in women aged 38 to 40 years.

10% in women aged 41 to 42 years.

4% in women aged 43 to 44 years.

1% in women older than 44 years of age. “

With conventional IVF, many sperm are placed with the egg for fertilization. If that doesn’t work, intercytoplasmic sperm injection– where the egg is held in place, the egg is pierced and one sperm is injected into the egg– is available.

The use of donor eggs increases with the age of the woman doing ART. Women under 35 (96%) tend to use their own eggs, while 68% of women over 45 use donor eggs. Use of donor eggs increases the success rate in completed pregnancy and live births for women over 45.

Cost of IVF

According to Forbes, the medications to stimulate egg production run between $3000 and $5000. A cycle of IVF costs around $12,000. For those who need pre-implantation genetic testing, which is used in cases where genetic disorders, like Tay Sachs or cystic fibrosis, are present in the couple, costs are between $3000 to $6000.

These numbers can make IVF prohibitive for many people. However, plans that feature single cycle versus multi-cycle options may reduce costs and there are also options which involve refunds (if a pregnancy does not occur). It is worth your while to do some research to find out what is available in your area.

Your Thoughts

What are your experiences with artificial reproductive technology? Do you have any advice for others dealing with fertility issues? How did you handle the cost of the experience? Please share your thoughts in the comments section below. If you have infertility issues, sign up for Medivizor.com and get up-to-date content in your inbox on infertility.

3 Comments

I had two cycles of IVF back in 1994. On my second cycle in December of 1994, 5 fertilized eggs were transferred into my uterus. I became pregnant with one child. This was in Knoxville, TN. I believe we were the first live birth from that clinic (University of TN.) They had an ART clinic previously but did not offer IVF. When they started performing IVF, they called their previously unsuccessful patients to offer first appointments. It was very expensive; more so in 1994 than now. I believe we spent around $25K per cycle. My husband had hurt his back at work and received some money for Workman’s Compensation. I also had broken my wrist at work and also received some money through WC. This money is what we used for our IVF cycles. Without that money, we would never have been able to have IVF. Our insurance would only cover costs associated with “fixing” what was causing the infertility. Since that could not be “fixed,” we had to continue to IVF. That series of procedures only bypasses the cause of infertility. The insurance covered none of the IVF procedures. It was a very stressful time; extremely hard on a marriage. I am so thankful to God that we were able to have a child – she is 21 years old, she is getting married in December of this year (2017), she has her Bachelor’s Degree in Psychology and is currently working on her Master’s Degree at Lee University (Cleveland, TN.) I am so proud of her and SO thankful for IVF. Without it, I would never have been able to have children.