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programs will not open

yesterday my computer was working fine this morning I cannot open any programs, none. I get a message that this " illeagal operation attempted on a registry key that has been marked for deletion". I cannot make anything work on my computer as i get this message for everything. I cannot open Explorer either. My computer was running slow so I tried to run ComboFix and it locked up. So I tried to run Malwarebytes and that is when I got the message above and get it for anything that I try to open.

I am using another computer to contact you and will need to burn all programs to disks to run in my computer.

FYI: The "Illegal operation attempted on a registry key that has been marked for deletion" message happens from time to time on Vista and Windows 7 computers. This is not a ComboFix specific problem as the message has also been reported when using other tools and sometimes when an Antivirus deletes files & registry entries that require a forced reboot.