The end of suffering is non-attachment, or letting go of desire or
craving. This is the state of Nibbana, where
greed, hatred and delusion are extinct.

Freedom from attachments to the five aggregates of attachment is the end of suffering.
This freedom is not conditioned by causes, as are the conditioned
states: Nibbana is the non-attachment to conditioned experience.

To understand the unconditioned, we need to see for ourselves that
everything that has a nature to be born has a nature to die: that
every phenomenon that has a cause is
impermanent. By letting go of
attachment to desire for conditioned phenomena, desire can come to an
end and we can be liberated from suffering.