The climate change resulting from human-caused emissions of carbon dioxide will persist for decades to millennia. Self-reinforcing cycles within the climate system have the potential to accelerate human-induced change and even shift Earth’s climate system into new states that are very different from those experienced in the recent past. Future changes outside the range projected by climate models cannot be ruled out, and due to their systematic tendency to underestimate temperature change during past warm periods, models may be more likely to underestimate than to overestimate long-term future change.