Anastrozole has been tested for reducing estrogens, including estradiol, in men. Excess estradiol in men can cause benign prostatic hyperplasia, gynec

Weigh Loss Steroids Powder Arimidex Anastrozoles CAS 120511-73-1

Anastrozole is also called Arimidex. It is a type of hormone therapy called an aromatase inhibitor. Anastrozole treats breast cancer in women who have had their menopause.Arimidex may sometimes be used to treat breast cancer in men.Anastrozole CAS: 120511-73-1Chemical dataFormula C17H19N5Mol. mass 293.366 g/mol

How anastrozole worksMany breast cancers are stimulated to grow by the female sex hormones oestrogen and progesterone. These breast cancers can be treated with drugs that block the effects of these hormones.In women who have had their menopause, oestrogen is mainly produced by changing androgens (sex hormones produced by the adrenal glands) into oestrogens. This process is called aromatisation and happens mainly in the fatty tissues, muscle and the skin. It needs a particular enzyme called aromatase.Arimidex blocks the process of aromatisation. So it lowers the amount of oestrogen in the body. In advanced breast cancer the cancer cells may grow more slowly or stop growing completely.

Usage in menAnastrozole has been tested for reducing estrogens, including estradiol, in men. Excess estradiol in men can cause benign prostatic hyperplasia, gynecomastia, and symptoms of hypogonadism.Some athletes and body builders use anastrozole as part of their steroid cycle to reduce and prevent symptoms of excess estrogen--gynecomastia, emotional lability and water retention.

Hormonal Therapy Lower Estrogen Level in Postmenopausal Women by AnastrozoleARIMIDEX (anastrozole) is a non-steroidal aromatase inhibitor. It is chemically described as 1,3-Benzenediacetonitrile, a, a, a', a'-tetramethyl-5-(1H-1,2,4-triazol-1-ylmethyl). Its molecular formula is C17H19N5.

Anastrozole is an off-white powder with a molecular weight of 293.4. Anastrozole has moderate aqueous solubility (0.5 mg/mL at 25°C); solubility is independent of pH in the physiological range. Anastrozole is freely soluble in methanol, acetone, ethanol, and tetrahydrofuran, and very soluble in acetonitrile.

DRUG CLASS AND MECHANISM

Anastrozole is an aromatase inhibitor, an anti-cancer medication use for the adjuvant or initial treatment of breast cancer in post-menopausal women. Estrogen causes or increases growth of certain breast cancers. Anastrozole works by blocking aromatase enzyme, which is involved in estrogen production in the body. This leads to decreased tumor size or delayed progression of tumor growth in some women. The FDA approved brand name anastrozole (Arimidex) in 1995.

PRESCRIBED FORAnastrozole is prescribed for hormone receptor-positive, early breast cancer in postmenopausal women as adjuvant treatment ( treatment following surgery with or without radiation ). Anastrozole is prescribed as a first-line treatment for hormone receptor-positive or hormone receptor unknown, locally advanced or metastatic breast cancer in postmenopausal women. Anastrozole is also prescribed for the treatment of advanced breast cancer in postmenopausal women with disease progression following treatment with tamoxifen (Nolvadex, Soltamox).

Anastrozole Help Shrink Tumor and Slow Their GrowthArimidex is a hormonal therapy used to treat breast cancer in women who have been through the menopause.Hormones are substances produced naturally in the body. They act as chemical messengers and help control the activity of cells and organs. Hormonal therapies work by interfering with the production or action of particular hormones in the body.

UsesThis medication is used to treat breast cancer in women who have gone through "the change of life" (menopause). Anastrozole works by lowering estrogen hormone levels to help shrink tumors and slow their growth.

Aromatase inhibitorsSome breast cancer cells have receptors, which allow particular types of hormones to attach to the cancer cell. In order to grow, many breast cancers rely on the hormone oestrogen. These cancers are known as oestrogen receptor-positive or ER-positive breast cancers.

In women who have had their menopause, the main source of oestrogen is through the conversion of androgens (sex hormones produced by the adrenal glands) into oestrogens. This is carried out by an enzyme called aromatase. The conversion process is known as aromatisation, and it happens mainly in the fatty tissues of the body.

Arimidex is a drug that blocks the process of aromatisation, and so reduces the amount of oestrogen in the body. As less oestrogen reaches the cancer cells, they grow more slowly or stop growing altogether. Drugs that work in this way are known as aromatase inhibitors|. Other aromatase inhibitors include letrozole(Femara) and exemestane (Aromasin).

Many breast cancer tumors grow in response to estrogen. This medicine interferes with the production of estrogen in the body. As a result, the amount of estrogen that the tumor is exposed to is reduced, limiting the growth of the tumor.

Anastrozole is Aromatase Inhibitor of ChoiceAnastrozole(marketed under the trade name Arimidex) is a non-steroidal aromatase-inhibiting drug approved for treatment of breast cancer after surgery, as well as for metastasis in both pre and post-menopausal women. The severity of breast cancer can be increased by estrogen, as sex hormones cause hyperplasia, and differentiation at estrogen receptor sites. Anastrozole works by inhibiting the synthesis of estrogen.

Why is this medication prescribed?Anastrozole is used with other treatments, such as surgery or radiation, to treat early breast cancer in women who have experienced menopause (change of life; end of monthly menstrual periods). This medication is also used in women, who have experienced menopause, as a first treatment of breast cancer that has spread within the breast or to other areas of the body. This medication is also used to treat breast cancer in women whose breast cancer has worsened after taking tamoxifen (Nolvadex). Anastrozole is in a class of medications called nonsteroidal aromatase inhibitors. It works by decreasing the amount of estrogen the body makes. This can slow or stop the growth of many types of breast cancer cells that need estrogen to grow.

Mechanism of actionAnastrozole binds reversibly to the aromatase enzyme through competitive inhibition, inhibits the conversion of androgens to estrogens in peripheral tissues (extra-gonadal).