Previous GeneCards Identifiers for SLC25A37 Gene

Summaries for SLC25A37 Gene

Entrez Gene Summary for SLC25A37 Gene

SLC25A37 is a solute carrier localized in the mitochondrial inner membrane. It functions as an essential iron importer for the synthesis of mitochondrial heme and iron-sulfur clusters (summary by Chen et al., 2009 [PubMed 19805291]).[supplied by OMIM, Jan 2011]

UniProtKB/Swiss-Prot for SLC25A37 Gene

Mitochondrial iron transporter that specifically mediates iron uptake in developing erythroid cells, thereby playing an essential role in heme biosynthesis. The iron delivered into the mitochondria, presumably as Fe(2+), is then probably delivered to ferrochelatase to catalyze Fe(2+) incorporation into protoprophyrin IX to make heme (By similarity).

Function for SLC25A37 Gene

Products:

Molecular function for SLC25A37 Gene

UniProtKB/Swiss-Prot Function:

Mitochondrial iron transporter that specifically mediates iron uptake in developing erythroid cells, thereby playing an essential role in heme biosynthesis. The iron delivered into the mitochondria, presumably as Fe(2+), is then probably delivered to ferrochelatase to catalyze Fe(2+) incorporation into protoprophyrin IX to make heme (By similarity).

Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.(PMID: 10931946)Hu RM … Chen JL(Proceedings of the National Academy of Sciences of the United States of America 2000)3460