In Ciphertext-Policy Attribute-Based Encryption (CP-ABE), a user secret key is associated with a set of attributes, and the ciphertext is associated with an access policy over attributes. The user can decrypt the ciphertext if and only if the attribute set of his secret key satisfies the access policy specified in the ciphertext. Several CP-ABE schemes have been proposed, however, some practical problems, such as attribute revocation, still needs to be addressed. In this paper, we propose a mediated Ciphertext-Policy Attribute-Based Encryption (mCP-ABE) which extends CP-ABE with instantaneous attribute revocation. Furthermore, we demonstrate how to apply the proposed mCP-ABE scheme to securely manage Personal Health Records (PHRs).