CS-11 PP2A–β-Catenin inhibitor RGNCY-0096

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CS-11 is a novel inhibitor of PP2A–β-Catenin signalling that limits both in vivo tumor growth and metastases. By inhibiting PP2A and β-Catenin interaction, Cs-11diminishes the expression of active β-Catenin and its target proteins c-Myc and Cyclin D1. It also promotes E-Cadherin upregulation on the cell surface and increases β-Catenin and E-Cadherin association that may prevent metastases.