Elucidation of Acid-Induced Pulmonary Inflammation

This study has been terminated.

(limited recruitment)

Sponsor:

University of Utah

ClinicalTrials.gov Identifier:

NCT00361972

First Posted: August 9, 2006

Last Update Posted: August 5, 2016

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government.
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This study will evaluate how heartburn may lead to different types of inflammation in one's airways. Additionally, the study will determine whether aggressive treatment of heartburn results in improvement in both symptoms of heartburn and asthma but also in documented improvement in airway inflammation as determined by biopsy. The results of this study will be important in directing future research into the relationship between heartburn and asthma and may provide a clue whether certain subtypes of asthma may be caused primarily by gastroesophageal reflux (GER).

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

Ages Eligible for Study:

18 Years to 65 Years (Adult)

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

No

Criteria

Inclusion Criteria:

chronic cough consistent with bronchoreactivity

Gastroesophageal reflux

Exclusion Criteria:

Severe asthmatics who have been hospitalized within the last 6 months or who have required oral steroid use within the last 4 weeks

Severe coronary artery disease

Cigarette/cigar smoking within the last 6 months

Documented allergies affecting the respiratory system

Subjects with contraindications to pH/impedance probe

Hemophilia

Septal deviation

Subjects with contraindications to bronchoscopy as outlined by the American Thoracic Society Guidelines

Anticoagulation

Pregnancy

Incarcerated patients

Current oral steroid use (may suppress levels of inflammation)

Upper respiratory infection within the last 2 weeks

Ongoing acid suppression with a proton pump inhibitor, however, patients may be included if they have discontinued their proton pump inhibitor within the last 1 month with stable asthma symptoms as defined by stable utilization of inhaled steroids

Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00361972