In an 2009 interview with EW, Locklear defended her character against accusations that Woodward is one of "TV's bitchiest," saying, "She isn't a bitch, she's just misunderstood. If she were a man, no one would comment about how she conducts business."

Locklear ended her engagement to her Melrose Place co-star (and on-screen love interest) Jack Wagner in 2011, after four years together.

Thomas Calabro

Getty Images

Calabro's character, Dr. Michael Mancini, was the only one to last the entire run of Melrose Place. After the show ended, Calabro went on to Nip/Tuck, Touched by an Angel, Castle, NCIS, CSI: NY, Greek, and the reboot of Melrose Place, among others.

Bissett has also become a successful children's book author. Her first book, Tickle Monster, came out in 2008, and she followed it up with Boogie Monster in 2011. As of 2012, she and Chef Danny Boome were working on a cookbook called Munchie Monster. Bissett plans to collaborate on another children's book with her daughter Maya. "I said, 'We should do it together,'" she told People, "And she was really excited about it."

Thorne-Smith told Good Morning America that after seeing a picture of herself in a magazine article about actresses who were too thin, she decided to break the cycle of obsessive diet and exercise she'd been in for years. "I thought, I hate the thought of a 12, 13, or 14-year-old girl seeing a picture of me and thinking she'll do what I did."

Vanessa Williams

Getty Images

Williams' character, Rhonda Blair, was written off of Melrose Placeafter only one season. "I think they didn't make the effort to equip themselves [to write for a black character], either by hiring a black writer or asking me things," Williams told TV Guide.

Shue worked with his sister, actor Elisabeth Shue, on the 2007 film Gracie, which is not only the story of Elisabeth's experience playing on her high school, all-boys' soccer team, but also of the loss of their brother, Will, who died in an accident in 1986.

In 2010, Shue marriedABC News correspondent Amy Robach. The two each had children from previous marriages: Shue had three sons from his marriage to Jennifer Hageney, and Robach had two daughters from her marriage to Tim McIntosh.

Grant Show

Getty Images

It was Grant Show's character, Jake Hanson, who started it all, as the bad-boy carpenter who helped Jackie Taylor and Mel Silver prepare for their wedding on Beverly Hills, 90210, ultimately becoming involved with Kelly Taylor. Hanson's character was spun-off of 90210, and right onto Melrose Place.

After MP, Show found roles on Six Feet Under, Beautiful People, Private Practice, Big Love, Criminal Minds, The Family, and Devious Maids.

Kristin Davis

Getty Images

Before she was Charlotte York on Sex and the City, Kristin Davis played the pregnancy-faking Brooke Armstrong on Melrose Place. In addition to SATC, Davis was the voice of Miss Spider on the cartoon series Miss Spider's Sunny Patch Friends, and in 2014, played Ginny Taylor-Clapp on CBS's Bad Teacher.

Laura Leighton

Getty Images

Leighton played Sydney Andrews on both the original Melrose Place and the reprise in 2009. Leighton, who is married to fellow MP alum Doug Savant, also appeared on Skin,Tru Calling, Law and Order: SVU, CSI: Miami, and more, before landing the role of Ashley Marin on Pretty Little Liars in 2010.

During a 2009 appearance on the Bonnie Hunt Show, Leighton said her older daughters were weirded out by her role on MP, which they're now old enough to watch. "It's like, 'Oh God, my mom's on this show.' Their phrase — to quote them — is 'Ah…ew…awkward,'" she shared.

Doug Savant

Getty Images

Matt Fielding, Savant's Melrose Place character, was at the forefront of openly gay characters being portrayed on television. After leaving MP in 1997, Savant's next major role was as Craig Phillips on 24, before joining the cast of Desperate Housewives in 2004, alongside MP alum Marcia Cross. He later appeared on Castle, Criminal Minds, the The X-Files reboot, and most recently, Notorious.

Savant turned down the offer to reprise his role as Matt in the 2009 Melrose Place reboot, saying that he was too busy at the time with Desperate Housewives, but he admitted, "Here's the truth: They need to get us old-timers back for a real old-school Melrose Place reunion. I'd come [back] for that."

Also a musician, Wagner's debut album, All I Need, was released in 1984, after signing a multi-record deal with Quincy Jones' Qwest Records. His sixth and latest album, On the Porch, a 12-song collection, came out in 2014.

Rob Estes

Estes then guested on Gilmore Girls, and had recurring roles on CSI: Miami, and Women's Murder Club before returning to the Spelling franchise to play Harry Wilson on the remake of Beverly Hills, 90210 in 2008. In 2016, he joined the cast of VH1's Daytime Divas, based on Star Jones' novel Satan's Sisters.

After spending several years living in Seattle with ex-wife Josie Bissett, Estes and wife Erin live in California with their son, Makai, 5, and Mason, Estes' teenaged son, with Josie Bissett.

Marcia Cross

Getty Images

Fans of Melrose Place certainly remember the scene in which Cross's character, Dr. Kimberly Shaw, pulls off her wig, revealing an intense scar. Cross left the show in season five, but that moment will live forever (along with the time she blew up the apartment building).

After MP, Cross guest-starred on basically every relevant television program at the time — including Seinfeld, Boy Meets World, and Ally McBeal — before spending a season on the WB's Everwood.

Kelly Rutherford

Getty Images

Rutherford's Megan Lewis materialized on Melrose Place in 1996. Post-series, Rutherford had recurring roles on The District, E-Ring, and Threat Matrix before landing Lily van der Woodsen on Gossip Girl. Her recent TV appearances have included Reckless, Quantico, and Jane the Virgin.

Rutherford's six year long custody battle for her children with her ex-husband Daniel Giersch ended in 2015, when Giersch won full custody. In 2012, a family court judge ordered that Giersch could not return to the US because of a revoked visa, and it was in the best interest of the children to remain in Monaco with their father. "I see them all the time," Rutherford told Page Six in 2016. "I was there eight weeks this summer…It was amazing."

Daphne Zuniga

Getty Images

Zuniga's Jo Reynolds lived on Melrose Place from 1992 until 1996. Zuniga later reunited with Melrose co-star Grant Show on the ABC series Beautiful People, and played characters in numerous TV films before joining the cast of One Tree Hill in 2008.

Cultural icons

In October 2012, the Melrose Place cast reunited for a segment on Good Morning America in which they reflected on their favorite moments on the show. For Thorne-Smith, it was playing "Drunk Allison," and for Leighton and Bissett, who played sisters, it was the countless times they couldn't stop laughing. Savant, for his part, remains proud of his Matt Fielding role becoming part of the lexicon of gay characters on network television.

While the apartment doors of Melrose Place are closed, one thing is certain: the actors on the show remain an important part of '90s nostalgia, one that can never quite be replicated.