It is the convent chapel of the Sisters of the Holy Family of Nazareth, which was founded in 1875 at Rome by a Polish expatriate called Blessed Maria Siedliska. She intended it to serve Polish expatriates, but it later had a ministry in independent Poland after 1920 and several sisters were martyred in the Second World War.

The congregation is now worldwide, but remains based at Rome and this convent is the provincial headquarters. (The Generalate is now a modern building at Via Nazareth 400, off the Via di Boccea.)

The convent was begun in 1884, the architect being Grazioli, and finished three years later.

The chapel has no independent architectural identity. However, the main entrance doorway to the convent is distinctive. The doorcase has an arch over a transom window, and above the arch is an entablature with a projecting cornice. Four rosettes decorated the doorcase, and above the cornice is a lunette (slightly more than semi-circular) containing a relief of the Holy Family. The rest of the building is typical Roman civic architecture of c1900.