bone morphogenetic protein

(redirected from Bone morphogenic peptide)

bone morphogenetic protein

Any of a family of 30–38-kD homodimeric growth factors involved in bone and cartilage formation, which provide morphogenetic signals that guide normal tissue architecture. Disregulation of BMP signalling is associated with cancer.

BMPs belong to the TGF-β supergene family; many growth/differentiation factors (GDFs) are in the BMP family, raising the number of known BMPs to 20. Although the name BMP describes the ability of BMPs to induce ectopic bone or cartilage formation, it is misleading in that BMPs are critical in development of the viscera and have roles in cell proliferation, apoptosis, differerntiation, and morphogenesis.

protein

(pro'ten?, te-in) [ proto- + -in]

Any of a class of complex nitrogen-containing compounds synthesized by all living organisms and yielding amino acids when hydrolyzed. Dietary proteins provide the amino acids necessary for the growth and repair of animal tissue.

Composition

All amino acids contain carbon, hydrogen, oxygen, and nitrogen; some also contain sulfur. About 20 different amino acids make up human proteins, which may contain other minerals such as iron or copper. A protein consists of from 50 to thousands of amino acids arranged in a very specific sequence. The essential amino acids are those the liver cannot synthesize (tryptophan, lysine, methionine, valine, leucine, isoleucine, phenylalanine, threonine, arginine, and histidine); because they cannot be made by the body, they must be consumed as food. A protein containing all of them is called a complete protein. An incomplete protein lacks one or more of the essential amino acids. The nonessential amino acids are synthesized by the liver.

Sources

Milk, eggs, cheese, meat, fish, and some vegetables such as soybeans are the best dietary sources of protein. Proteins are found in both vegetable and animal food sources. Many incomplete proteins are found in vegetables; they contain some but not all of the essential amino acids. A vegetarian diet can compensate for dietary protein deficiencies by combining vegetable groups that complement each other in their basic amino acid groups.

Principal animal proteins are lactalbumin and lactoglobulin in milk; ovalbumin and ovoglobulin in eggs; serum albumin in serum; myosin and actin in striated muscle tissue; fibrinogen in blood; serum globulin in serum; thyroglobulin in thyroid; globin in blood; thymus histones in thymus; collagen and gelatin in connective tissue; collagen and elastin in connective tissue; and keratin in the epidermis. Chondroprotein is found in tendons and cartilage; mucin and mucoids are found in various secreting glands and animal mucilaginous substances; caseinogen in milk; vitellin in egg yolk; hemoglobin in red blood cells; and lecithoprotein in the blood, brain, and bile.

Function

Ingested proteins are a source of amino acids needed to synthesize the body's own proteins, which are essential for the growth of new tissue or the repair of damaged tissue; proteins are part of all cell membranes. Excess amino acids in the diet may be changed to simple carbohydrates and oxidized to produce adenosine triphosphate and heat; 1 g supplies 4 kcal of heat.

Infants and children require from 2 to 2.2 g of dietary protein per kilogram of body weight each day for normal health and development. The World Health Organization recommends that healthy adults consume about 0.8 g of protein per kg of body weight daily. The calculation should be made on the basis of ideal body weight rather than the actual weight of the adult or child. High levels of exercise, menstruation, pregnancy, lactation, and convalescence from severe illness require increased protein intake. Excess protein in the diet results in increased nitrogen excretion in the urine.

accessory protein

A protein that works with another protein, e.g., in helping it to fold into its normal shape or become anchored into its preferred location in a cell membrane.

activator protein

A protein that stimulates the expression of a gene.

acute phase protein

Any of the plasma proteins whose concentration increases or decreases by at least 25% during inflammation. Acute-phase proteins include C-reactive protein, several complement and coagulation factors, transport proteins, amyloid, and antiprotease enzymes. They help mediate both positive and negative effects of acute and chronic inflammation, including chemotaxis, phagocytosis, protection against oxygen radicals, and tissue repair. In clinical medicine the erythrocyte sedimentation rate or serum C-reactive protein level sometimes is used as a marker of increased amounts of acute-phase proteins. Synonym: acute phase reactant See: inflammation

adapter protein

An intracellular molecule that undergoes structural and functional changes in response to binding of cell membrane receptors by ligands. Adapter proteins participate in the immune response by acting as a bridge for enzymes in the signaling pathway needed to activate lymphocytes and initiate a response to an antigen.

amyloid precursor protein

Abbreviation: APP

An integral membrane protein concentrated at neuron synapses that is cleaved biochemically into components, one of which is the Alzheimer's disease–associated beta amyloid. Mutations in the gene for APP on chromosome 21 account for less than 5% of early-onset familial Alzheimer's disease.

Bence Jones protein

binding protein

A protein that is linked to another chemical in the body, either transporting it through the blood or helping to convey it into cells across cell membranes. Examples of binding proteins include ceruloplasmin, sex hormone-binding globulin, and transcobalamin, which carries vitamin B12.

blood protein

A broad term encompassing numerous proteins, including hemoglobin, albumin, globulins, the acute-phase reactants, transporter molecules, and many others. Normal values are hemoglobin, 13 to 18 g/dL in men and 12 to 16 g/dLl in women; albumin, 3.5 to 5.0 g/dL of serum; globulin, 2.3 to 3.5 g/dL of serum. The amount of albumin in relation to the amount of globulin is referred to as the albumin-globulin (A/G) ratio, which is normally 1.5:1 to 2.5:1.

bone morphogenetic protein

A bone graft substitute.

protein C

A plasma protein that inhibits coagulation factors V and XIII, preventing excessive clotting. Deficiency of this protein or resistance to its effects may lead to deep venous thrombosis and pulmonary embolism. In the presence of thrombin, protein C is activated, forming activated protein C.

coagulated protein

coat protein

complement S protein

complete protein

A protein containing all the essential amino acids.

conjugated protein

A protein that is chemically linked with a nonprotein molecule. Included are chromoproteins (e.g., hemoglobin); glycoproteins (e.g., mucin); lecithoproteins, nucleoproteins, and phosphoproteins (e.g., casein).

C-reactive protein

Abbreviation: CRP

The first acute phase protein identified. It binds with phospholipids on foreign substances, activates the complement system, stimulates the production of cytokines, and inhibits the production of oxygen radicals by neutrophils. Increased blood levels of CRP are present in many infectious and inflammatory diseases (including in patients with coronary artery disease, in whom it is sometimes employed as a risk factor). CRP levels are sometimes monitored serially to determine if infectious or inflammatory diseases have been effectively treated.

decorin-binding protein

One of two antigens released by Borrelia burgdorferi (the spirochete that causes Lyme disease). The antigen may be useful as a target for Lyme disease vaccination.

denatured protein

A protein in which the amino acid composition and stereochemical structure (shape) have been altered by physical or chemical means. See: coagulated protein

derived protein

A protein altered chemically or physically.

fusion protein

A protein made from the natural or artificial hybridization and translation of two distinct genes.

G protein

A cellular protein activated by the binding of an intercellular signal to its receptor on the cell membrane; the G-protein then activates the enzyme adenyl cyclase within the cell, triggering the formation of cyclic AMP and a stereotyped response.

glial fibrillary acidic protein

Abbreviation: GFAP

An intermediate filament found only in astrocytes and astroglial cells. It forms part of the skeletal structure of neurons. Abnormalities in GFAP are found in a variety of neurological diseases, including Alzheimer's disease, Creutzfeldt-Jakob disease, and some brain tumors.

glycosyl phosphatidyl inositol anchor protein

Any of the structural components of the red blood cell membrane. Their absence from cells is responsible for cellular destruction (hemolysis) in paroxysmal nocturnal hemoglobinuria.

heart fatty acid-binding protein

Abbreviation: H-FABP

A biomarker in the serum of patients with injury to myocardial cells. It is present in the serum within about an hour after heart muscle cells are deprived of blood.

heat shock protein

Any of a large group of proteins that protect cells from injury caused by increased temperatures or other physical stresses.

Synonym: stress response protein

heparin-binding protein

A proinflammatory, antimicrobial peptide released by neutrophils. It increases the permeability of blood vessels. It is found in high concentrations in plasma of patients with septic shock.

HFE protein

A protein normally found intracellularly in duodenal crypt enterocytes and the placenta. It is closely associated with transferrin receptors for iron and regulates iron absorption. HFE is a homologue of class I major histocompatibility complex (MHC) molecules. The C2824 and H63D mutations on chromosome 6 in the HFE gene cause hemochromatosis.

high-mobility–group box chromosomal protein 1

Abbreviation: HMGB1

A component of chromatin, released as a cytokine in the systemic inflammatory response of sepsis.

immune protein

An antibody or immunoglobulin produced by plasma cells that identifies foreign antigens and initiates their destruction.

incomplete protein

lipopolysaccharide-binding protein

One of many acute-phase proteins released into the serum in patients with a gram-negative bacterial infection; it helps to defend the body against sepsis by binding and transferring bacterial endotoxin.

M protein

A protein in the cell wall of group A streptococci that helps to inhibit the ingestion of bacteria by polymorphonuclear white blood cells. Some of the more than 80 identified M proteins have been linked to poststreptococcal acute rheumatic fever. Others have been linked to poststreptococcal acute glomerulonephritis.

membrane-bound protein

, membrane protein

A protein that is part of a cell membrane and acts as a receptor for substances transported in extracellular fluid or as an agent that mediates the transport of chemicals into or out of the cell.

native protein

A protein in its natural state; one that has not been denatured.

nuclear matrix protein 22

Abbreviation: NMP22

A tumor marker excreted in the urine of some patients with bladder cancer. NMP22 can be used to screen patients for the disease, esp. for recurrence of the disease after primary treatment.

nucleotide-binding oligomerization domain protein

Abbreviation: NOD

Any of a family of cytoplasmic proteins that recognize molecules associated with disease-causing bacteria and stimulate cells to secrete cytokines and costimulatory molecules. Inappropriate regulation of nucleotide-binding oligomerization domain proteins has been linked to the pathogenesis of Crohn's disease and other syndromes.

oncofetal protein

plasma protein

A protein present in blood plasma, such as albumin or globulin.

pregnancy-associated plasma protein A

Abbreviation: PAPP-A

A plasma protein that is used as a screening test between 8 and 14 weeks gestation; diminished levels of the protein suggest an increased risk for Down syndrome, intrauterine growth retardation, preeclampsia, and stillbirth.

protein S

A vitamin-K dependent protein that acts with protein C to prevent blood clotting. Deficiencies may lead to venous thrombosis and pulmonary embolism. See: protein C

sarcomeric protein

Any of the proteins in a sarcomere that contribute to the contraction of a muscle fiber. These proteins include actin, myosin, troponin, and nebulin.

serum protein

Any protein in the blood serum. The two main fractions are albumin and the globulins. Serum protein forms weak acids mixed with alkali salts; this increases the buffer effects of the blood but to a lesser extent than does cellular protein.

simple protein

Any of the proteins that produce alpha amino acids on hydrolysis (e.g., albumins, albuminoids, globulins, glutelins, histones, prolamines, and protamines).

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