DevBio 9th

Developmental Biology, Ninth Edition

Scott F. Gilbert

About This Title

During the past four years, the field of developmental biology has begun a new metamorphosis. The Ninth Edition of Developmental Biology mirrors this shift with a wholly revised text, over 600 new literature citations, and substantial reorganization of content. The introductory section has been streamlined from six chapters to three—one each on developmental anatomy, the mechanisms of gene regulation during differentiation, and cell–cell communication during morphogenesis. Another new feature is the addition of short part openers that address key concerns in developmental biology. These provide an introduction to the subsequent chapters, telling the reader what to expect and placing that information into a specific context. Each chapter ends with a guide to Web-based resources relevant to that chapter’s content, and the Ninth Edition is the first to include a glossary of key terms. Some of the new material in this edition includes: mesenchymal and induced pluripotent stem cells; the transdifferentiation of pancreatic cells; new data on sea urchin micromere specification; the mechanisms whereby Sry and Wnt signaling determine mammalian sex; the memory of cell fate during amphibian limb regeneration; how bats got their wings and how dachshunds got their short legs.

Ninth Edition Features and Supplements

A completely updated text includes fundamental new material that alters what we teach in developmental biology courses.

DevBio Laboratory: Vade Mecum3Included inside every copy of the book is an online access code for Mary Tyler and Ron Kozlowski’s remarkable resource, DevBio Laboratory: Vade Mecum3. Online access may also be purchased separately.

Companion Website (www.devbio.com)Cross-referenced throughout the textbook, this resource provides more information for advanced students, historical, philosophical, and ethical perspectives on issues in developmental biology, videos, interviews, Web links, and updates. The website includes the full bibliography of literature cited in the book, most of which are linked to their PubMed citations. Also, for the Ninth Edition, Susan Singer’s chapter on plant developmental biology has been moved to this location.

Instructor’s Resource LibraryThe Developmental Biology, Ninth Edition Instructor’s Resource Library contains: all the figures (including photographs) and tables from the textbook in JPEG (high- and low-resolution) and PowerPoint® formats; a video collection; videos, images, and the Instructor’s Guide from DevBio Laboratory: Vade Mecum3; and the Instructor’s Guide to Differential Expressions2.

About the Author

Scott F. Gilbert, the Howard A. Schneiderman Professor of Biology at Swarthmore College, teaches developmental biology, developmental genetics, and the history of biology. After receiving his B.A. from Wesleyan University, he pursued his graduate and postdoctoral research at The Johns Hopkins University and the University of Wisconsin. Dr. Gilbert is the recipient of several awards, including the first Viktor Hamburger Award for excellence in developmental biology education, the 2004 Alexander Kowalevsky Prize for evolutionary developmental biology, an honorary degree from the University of Helsinki, and the Medal of François I from the Collège de France. He is a Fellow of the American Association for the Advancement of Science, and a corresponding member of the St. Petersburg Society of Naturalists. His research is sponsored by the National Science Foundation and involves the developmental genetic mechanisms by which the turtle forms its shell.

Value Options

Looseleaf TextbookThe complete full-color Ninth Edition is available in a three-hole punched looseleaf format. Students can take just the sections they need to class and can easily integrate instructor material with the text.ISBN 978-0-87893-558-1

Interactive eBookhttp://ebooks.sinauer.com/gilbert9eThe interactive eBook features a wealth of interactive tools and resources. For instructors, the eBook offers an unprecedented opportunity to easily customize the textbook with the addition of notes, Web links, images, documents, and more. Students can readily bookmark pages, highlight text, add their own notes, and customize the display of the text. All of the Companion Website’s resources are integrated directly into the eBook, so that students can easily access them while reading the text.ISBN 978-0-87893-412-6, 180-day subscription

CourseSmart eBookhttp://www.coursesmart.com/9780878933846This basic eBook reproduces the look of the printed book exactly, and includes convenient tools for searching the text, highlighting, and adding notes.ISBN 978-0-87893-409-6, 180-day subscription

New Material

Developmental biology differs enormously from the field four years ago. Here, by chapter, are some of the exciting new discoveries and principles incorporated into Developmental Biology, Ninth Edition:

I. Principles: Introducing Developmental Biology

Introducing the questions and principles that are the foundation of developmental biology

1. Developmental anatomy

Evolutionary developmental biology of bat wings and dachshund legs

2. Developmental genetics

Roles of microRNAs in controlling cell identity

Histone remodeling

Reprogramming exocrine pancreas into beta-cells

Dscam splicing

Translation initiation

3. Cell–cell communication in development

Epithelial–mesenchymal transitions

Cell shape change and morphogenesis

Elasticity of extracellular matrix regulating differentiation

Coordination of cell migration

II. Specification: Introducing Early Embryonic Development

An introduction to the modes of specification and determination used in the animal kingdom

4. Fertilization

Soluble PLC-zeta in mammalian fertilization

The mechanisms for cortical granule exocytosis

Mammalian blocks to polyspermy

Regulation of acrosome reactions

5. Early development in selected invertebrates

Specification of sea urchin micromeres and recruitment of skeletogenic genes

Regulation of sea urchin gastrulation

Double-negative gate gene circuits

Left–right axis formation in snails, tunicates, and nematodes

Mollusk D-quadrant signaling

Centrosome-attracting bodies in tunicate development

6. The genetics of axis specification in Drosophila

Smaug in maternal-to-zygote transition

The bicoid mRNA gradient

Cytoskeletal and cell adhesion changes induced by homeotic genes

Mechanisms of cellularization

Mechanisms of posterior localization

Realisator gene pathways

7. Amphibians and fish: Early development and axis formation

Cell adhesion and cell shape changes during gastrulation

Vg1 signaling for mesoderm and endoderm specification

Importance of Wnt11 for dorsal–ventral polarity

New pathway of organizer formation

Single-cell internalization in zebrafish gastrulation

8. Birds and mammals: Early development and axis formation

Intercalation and primitive streak formation

How the amniote mesenchyme cells are instructed to ingress into the embryo

Specification of chick germ layers

How the mammalian inner cell mass separates from the trophectoderm

How the embryonic axis is established in the blastocyst

III. Stem Cells: Introducing Organogenesis

An introduction to the stem cell concept, including new material on embryonic and induced stem cells, mesenchymal stem cells, and the construction of stem cell niches

9. The emergence of the ectoderm: CNS and epidermis

How the layers of the mammalian cortex are defined and how cells are instructed to reach these layers

The developmental regulatory genes that may be involved in primate brain evolution

How the hair follicles become spaced and the hair shaft grows

EDAR mutations and epidermal appendages

Multipotent retinal stem cells and their specification by microRNAs and timing