Objective: The primary objective of this study was to compare the analgesic effects of intrathecal ropivacaine with or without neostigmine or dexmedetomidine in lower limb surgeries. Secondary objectives were to study the characteristics of block, duration of analgesia, postoperative analgesic requirement, and associated side effects. Materials and Methods: Seventy-five patients posted for elective orthopedic lower limb surgeries under spinal anesthesia were randomly divided into three equal groups to receive intrathecal ropivacaine 0.5% alone (Group R), with adjuvant 5 μg dexmedetomidine (Group R + D) or 50 μg neostigmine (Group R + N). Time to achieve T10 sensory block, time to 2-segment regression, duration of regression to L4, maximum modified Bromage score and duration of analgesia were noted. The incidences of adverse events such as nausea, vomiting, hypotension, bradycardia, desaturation, shivering, and itching were also noted. Statistical analysis was performed using two sample t-test for normally distributed variables and Pearson's Chi-squared test for categorical data. The level of significance was set as P < 0.05. Results: Quality of motor and sensory blockage was significantly better in both Group R + D and Group R + N than Group R. Mean time to achieve T10 sensory block was lowest, time taken in regression of block by 2-segments and duration of regression to L4 was longest in Group R + D and was significant when compared to other groups. Adverse effects such as nausea and vomiting were highest in Group R + N and was statistically significant as compared to other groups. Conclusions: Dexmedetomidine is a better intrathecal adjuvant emerged as compared to neostigmine due to faster onset of anesthesia, better intra- and post-operative analgesia and prolonged duration of motor and sensory blockade without significant increase in adverse effects.