I am very interested in studying the relationship between signaling
pathways and human cancers. Currently we are looking for the
relationship between Wnt-signal transduction and two very common
cancers in Iran, gastric and esophageal tumors. We are screening
tumor samples for mutations in exon 3 of β-catenin gene that has a
critical role in the regulation of Wnt-signaling. I am also
interested in anti-tumor activities of natural products. At present
four students are working under my supervision who will graduate
soon.

Teaching Activities:

I teach undergraduate and graduate
courses about molecular genetics and molecular basis of human
cancers.

2-S Mahmoud A Najafi.
(Oral presentation): “Role of G-proteins in the regulation of Wnt-signal
transduction”. First Iranian Conference for Cell and Developmental
Biology, University of Tehran. 13-14 September 2003.

4-S Mahmoud A Najafi.
(Oral presentation): “Expression of the mouse Gaq using
Baculovirus expression system”. The 3rd National
Congress of Biotechnology. The Islamic Republic of Iran. University
of Ferdowsi, Mashad-Iran. 9-11 September 2003.