Tia Dalma plays an important role in finding the pieces of the Kraken's Bane. Once she is found, she will only agree to help if the player finds the pieces of and reconstructs a local statue. She then tells the locations of the many pieces to the Kraken's Bane located on other ports and islands and is also responsible for raising a sunken ship from the depths to retrive one of them.

Tia Dalma was a mysterious voodoo mystic in the Caribbean. Before she was known as Tia Dalma, she was the sea goddess Calypso. This was until the First Brethren Court tricked the goddess and imprisoned her into the body of a mortal woman.
A woman of power, Tia Dalma resided deep within the bayou swamps of Cuba, in a sprawling wooden shack perched in a treetop by the mouth of the Pantano River. Some believed that judging Tia Dalma by her humble home was a mistake as she had uncanny powers to foretell the future, to summon demons, and to look deep into men's souls. She had devoted her powers to help anyone who needed it. So it was to this mysterious and beautiful mystic that Jack Sparrow occasionally turned to for help and who once provided him with his unique compass. Tia Dalma also had dealings with Angelica, who traded a ring in order to learn the Profane Ritual.

Over the years, the imprisoned Calypso assumed the alias of Tia Dalma. It wasn't until the War Against Piracy that she gained an opportunity for freedom from her human bonds. Tia Dalma/Calypso needed all the Pirate Lords in order to assemble the Brethren, so they could release her from her human bonds. She resurrected Hector Barbossa and tricked him to retrieve Jack Sparrow from Davy Jones' Locker and summon a fourth meeting of the Brethren. Despite the Pirate Lords not having an agreement, Barbossa took all the Pieces of Eight, the powerful items that had imprisoned Calypso, and then undid the spell that bound her to mortal flesh. Now free, Calypso's wrath became horrible to behold, having discovered Davy Jones' betrayal. The enraged goddess created a massive maelstrom, where a battle raged at the center of it. And it was in that very battle that Davy Jones' heart was pierced and he died.