2004-027 – To accomplish a given computational task, a number of algorithmic and heuristic approaches can be implemented to act upon the given instance of the input data. Depending upon the intrinsic and extrinsic assumptions made regarding the data, algorithm and the task, the end result from each of these approaches could be different. Currently, there does not exist an automatic fast, robust, precise... Read More

2004-023 – This invention presents a method for producing multiple MR images with different contrast from a single image acquisition. (MR T2) The methodology is used to enhance the T2 related contrast in an MRI image acquired at, but no restricted to, just-enough-to-highlight-T2, repetition time so as to produce a computed mosaic of the same image at different repetition (TR) and echo (TE) times. This... Read More

2004-020 – The CCAP program accurately and efficiently counts and analyzes cells in microscope images. A user interactively completes the followings steps: 1) Inhomogeneity correction: A digital filter is applied to correct for uneven illumination. 2) Calibration: A line is placed over an object of known size, usually a ruler, to determine the size of the image pixels. 3) Segmentation: The cells... Read More

2004-012 – There are a variety of devices being developed to significantly improve the testing, characterization, and development of differential protocols, equipment, and devices. In essence, these devices provide a way of dealing with differential signals within a laboratory environment.

2004-008 – The motion correction strategy compensates for rigid-body in-plane rotation and translation of the imaged object by collecting radial MRI data with a novel projection view angle acquisition order followed by a data correction algorithm. A custom MR pulse sequence was created to collect radial projections with a consistent spacing of approximately 45 degrees, which is crucial for the novel... Read More

2003-199 – The invention is an ultra-miniature transceiver technology that allows positioning, data relaying and identification in a very tiny form factor (e.g., “pinhead” size). The transceiver is based on a system-on-a-chip (SOC) design of a radio frequency (RF) transceiver that is combined with a micro-miniature battery and an antenna (or in some cases two antennas). The invention enables... Read More

2003-196 – Transgenic mice were created through DNA microinjection of a construct utilizing mouse EPO derived regulatory sequences in conjunction with the Diptheria Toxin A chain (DT-A) open reading frame and a series of exons/introns derived from the human growth hormone gene to provide the necessary splicing events required for high-level expression. Assessments of circulating leukocytes and other... Read More

2003-185 – The invention describes a new algorithm and hardware architecture to compute the fast Fourier transform (FFT). The new algorithm uses a divide and conquer approach to reduce an N point FFT to a plurality of sqrt(N) point FFTs arranged in a pipeline configuration. A new specialized center element joins identical, conventional pipeline FFT units together and provides the necessary control logic... Read More

2003-150 – A mouse lacking both copies of the IEX-1 gene was generated. These mice have a mean arterial blood pressure that is approximately 30mm of Hg higher than that seen in wild type mice. These mice are useful for assessing compounds for the ability to reduce high blood pressure.

2003-090 – Hydrogel microparticles with entrapped liquid are used as the porogen to reproducibly form interconnected pore networks in a porous scaffold. In one embodiment, a biodegradable unsaturated polymer (for example, PPF or PCF), a crosslinking agent (like a free radical initiator), and a porogen comprising biodegradable hydrogel microparticles (such as OPEF) are mixed together and allowed to form... Read More

2003-048 – Method to Optimize Antigen Expression When Culturing Cells for Cancer Vaccines
The culture of cells for use in cancer vaccines or for use in the discovery of tumor antigens occurs in a standard oxygen pressure environment of about 20 kilopascals (kPa). Mayo Clinic researchers have discovered that culturing cancer cells in a low (2 kPa) or high (90kPa) oxygen pressure increases expression... Read More

2003-044 – Mayo Clinic researchers have created a biocompatible and bioresorbable PCF material for injectable and in-situ scaffolds by polymerizing a PCF macromer with a salt of fumaric acid that self-crosslinks.

2002-244 – Mayo has discovered a gene, PKHDL1, that shows significant homology to PKHD1 (the gene mutated in autosomal recessive polycystic kidney disease that was discovered at Mayo and for which a patent application is pending). The protein predicted to be encoded by PKHDL1, fibrocystin-L, is a large receptor-like protein that is highly expressed on T lymphocytes. The protein is postulated to be an... Read More

2002-227 – The enzyme utilizes S-adenosylmethionine to methylate aresenite to monomethylarsonate, and can further methylate this product to form dimethylarsinic acid. Known substrates are Aresenite, Methylarsonous acid, Methylarsonous acid. It is known to be expressed in liver, kidney and brain. Arsenic exposure outcomes (death, cancer, neurotoxicity, liver damage, and cardiovascular disease et. al.)... Read More

2002-226 – Our invention is the use biological, pharmacological or saccharide intervention, genetic modification or selection, for antagonist or modulation of Toll-like receptor 4 (TLR4) or other TLRs for the increase and/or maintenance of bone density, osteoporosis, Paget’s disease, or any disease or condition in which bone loss is a factor.

2002-225 – Our invention is the use biological, pharmacological or saccharide intervention, genetic modification or selection, for antagonist or modulation of Toll-like receptor 4 (TLR4) or other TLRs for the maintenance, or reduction of fat body mass, obesity or any related conditions or diseases where body fat is a contributing factor.

2002-179 – Mayo researchers have developed a method to allow clinical x-ray imaging to reach its full potential. This is achieved by reducing the x-ray dose absorbed by the patient by orders of magnitude and by enhancing the contrast discrimination of the x-ray interaction with different soft-tissue components so that little, if any, contrast agent need be administered. The Time-Of-Flight X-ray... Read More

2002-152 – PNMT is the terminal enzyme in catecholamine biosynthesis and catalyses the synthesis of epinephrine from norepinephrine. Norepinephrine and Phenylethanolamine are substrates. The activation is methylation. It is expressed in Chromaffin cells of the Adrenal Medulla, medulla oblongata, hypothalamus, and sensory nuclei of the vagus nerve. Diseases and conditions that may be associated with... Read More

2002-151 – SULT1A3 is involved in the sulfation of Dopamine,other catechol monoamines, serotonin, and Troglitazone. It is expressed in liver, brain, jejunum, kidney and platelets. It may be associated with schizophrenia, affective disorders, renal disease and chemical carcinogenesis. One particular polymorphism, resulting in an amino acid change, was found to be present in 4% of the African American... Read More

2002-136 – Rabbit polyclonal antisera were produced against human and murine Vav-3 proteins using KLH-conjuaged peptides. These antisera recognize an approximately 98 kilodalton protein corresponding to Vav3.

2002-103 – We present a method for performing de-embedding (or equivalently, second-tier calibration) of vector network analyzer (VNA) measurements allowing for very accurate measurement to reference planes beyond those of a first tier calibration. The method has been proven to be useful up to very high frequencies (at least 110 GHz) and eliminates many of the complexities and limitations associated... Read More

2002-074 – A peripherally inserted central catheter includes three lumens that communicate with its proximal end. A large lumen terminates short of the distal end of the catheter and is used for the infusion of fluids into the venous system. A second lumen terminates at the distal end and is suitable for measuring blood pressure in the central venous system and infusion of fluids into the central venous... Read More

2002-072 – Mayo Clinic researchers have developed a biodegradable polymer device for bridging a gap in a severed nerve. This implant functions both as a scaffold to support axon growth across a gap and as a conduit for the controlled local delivery of agents which may promote axon regeneration.

2002-047 – This is a portable (hand carried), adjustable height, suitcase-style device which stores, in insultated storage compartments, and permits correct anatomic mounting of, harvested porcine upper and lower gastrointestinal tracts on each half of the opened device. This device is intended to demonstrate endoscopic procedures, both diagnostic and therapeutic, using ex vivo animal gastrointestinal... Read More

2002-039 – Technology Description
T cell-mediated immune responses are often harmful in transplant patients and patients with autoimmune disease. Currents treatments to suppress T cell-mediated immune responses include a number of immunosuppressive and anti-inflammatory therapies. A novel means of suppressing this immune response has been developed that utilizes mutant forms of a protein normally... Read More

2002-038 – A synthetic valve/leaflet for manufacturing cardiac valve prostheses - mechanical characteristics include anysotopic elasticity - contains stress-bering fibers and is fitted with a thicker area resembling the Nodule of Arantzius of the mature aortic valves.

2001-160 – A common problem in clinical magnetic resonance imaging is misalignment of the individual imaging slices on sequential patient examinations. This inter-image misregistration frequently confounds accurate assignment of change or lack thereof in pathologic lesions across serial studies. We describe a rapid and accurate method to register the individual slices of MR images obtained at... Read More

2001-158 – The Avian Leukosis Virus (AVL) group of retroviruses offers a novel platform for the display of polypeptides and offers novel applications for polypeptide display technology. The ability to display polypeptides on the ALV envelope glycoproteins in a replicating retrovirus with an additional expression cassette presents several unique approaches to use this display platform to probe the... Read More

2001-139 – There are two separate 3'-phosphoadenosine 5'-phosphosulfate synthetase (PAPSS) isoforms in humans (PAPSS1 and PAPSS2). Both isoforms catalyze the formation of PAPS, the universal high-energy sulfate donor for all sulfotransferases. Functionally relevant PAPSS1 polymorphisms have been discovered that decrease PAPSS1 activity and result in undersulfation of drugs, procarcinogens, glycoproteins... Read More

2001-138 – SULT1E1 catalyzes reactions with steroid hormones e.g. ß-Estradiol, by transferring a sulfonate group from PAPS to the hydroxy group at position 3 of the estrogen to form Estradiol 3-O-sulfate. Known substrates are estrone and estradiol, catecholestrogens and 2-Methoxyestradiol. SULT1E1 is expressed in the liver, small intestine, adrenal cortex, adrenal medulla, lung, kidney, mammary gland,... Read More

2001-069 – Rigid body translations of an object in MRI will create image artifacts along the phase enclode (PE) direction in standard 2DFT imaging. If two images are acquired with swapped PE direction, it is theoretically possible to determine and correct for arbitrary translational motions in both images directly from the phase differences in the k-space acquisitions by solving a large system of... Read More

2001-040 – Using monoclonal antibodies (mAb) to 4-1BB (CD137) T cell molecule, we will be able to show that this treatment can regress established tumors in mouse models in combination with antigenic peptides and cytokine-modified tumor vaccines. Furthermore, treatment by anti-4-1BB mAb also ameliorates experimental autoimmune encephalomyelitis (EAE) in mice, a model of multiple sclerosis in human. ... Read More