Fusion

STRING allows inspection of the interaction evidence for any given network. Choose any of the viewers above (disabled if not applicable in your network).

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:query proteins and first shell of interactors

white nodes:second shell of interactors

Node Content

empty nodes:proteins of unknown 3D structure

filled nodes:some 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

IL1491

ATP-dependent RNA helicase (372 aa)

Predicted Functional Partners:

eno

Enolase; Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (430 aa)

0.871

rraA

Demethylmenaquinone methyltransferase; Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (161 aa)

0.847

rpsO

Ribosomal protein S15; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA (89 aa)

0.842

cspE

Cold shock protein (69 aa)

0.827

cspD

Cold shock protein (71 aa)

0.827

IL0033

Cold shock protein (68 aa)

0.827

pnp

Polynucleotide phosphorylase; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3’- to 5’-direction (716 aa)

a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1

node2

node1 accession

node2 accession

node1 annotation

node2 annotation

score

IL0033

IL1491

IL0033

IL1491

Cold shock protein

ATP-dependent RNA helicase

0.827

IL0033

hrpB

IL0033

IL2247

Cold shock protein

Helicase, ATP-dependent

0.692

IL0033

pnp

IL0033

IL0964

Cold shock protein

Polynucleotide phosphorylase; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3’- to 5’-direction

0.406

IL0033

rhlE

IL0033

IL1546

Cold shock protein

ATP-dependent RNA helicase

0.827

IL1491

IL0033

IL1491

IL0033

ATP-dependent RNA helicase

Cold shock protein

0.827

IL1491

cspD

IL1491

IL0676

ATP-dependent RNA helicase

Cold shock protein

0.827

IL1491

cspE

IL1491

IL2493

ATP-dependent RNA helicase

Cold shock protein

0.827

IL1491

eno

IL1491

IL0772

ATP-dependent RNA helicase

Enolase; Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis

0.871

IL1491

hrpB

IL1491

IL2247

ATP-dependent RNA helicase

Helicase, ATP-dependent

0.797

IL1491

pnp

IL1491

IL0964

ATP-dependent RNA helicase

Polynucleotide phosphorylase; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3’- to 5’-direction

0.820

IL1491

rhlE

IL1491

IL1546

ATP-dependent RNA helicase

ATP-dependent RNA helicase

0.807

IL1491

rpmD

IL1491

IL1898

ATP-dependent RNA helicase

Ribosomal protein L30

0.805

IL1491

rpsO

IL1491

IL0965

ATP-dependent RNA helicase

Ribosomal protein S15; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA

0.842

IL1491

rraA

IL1491

IL2455

ATP-dependent RNA helicase

Demethylmenaquinone methyltransferase; Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome

0.847

cspD

IL1491

IL0676

IL1491

Cold shock protein

ATP-dependent RNA helicase

0.827

cspD

hrpB

IL0676

IL2247

Cold shock protein

Helicase, ATP-dependent

0.692

cspD

pnp

IL0676

IL0964

Cold shock protein

Polynucleotide phosphorylase; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3’- to 5’-direction

0.406

cspD

rhlE

IL0676

IL1546

Cold shock protein

ATP-dependent RNA helicase

0.827

cspE

IL1491

IL2493

IL1491

Cold shock protein

ATP-dependent RNA helicase

0.827

cspE

hrpB

IL2493

IL2247

Cold shock protein

Helicase, ATP-dependent

0.750

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Network Stats

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Functional enrichments in your networkNote: some enrichments may be expected here (why?)

Enrichment analysis is still ongoing, please wait ...

Statistical background

For the above enrichment analysis, the following statistical background is assumed: