Sakura Syndrome

Named after the highest profile and best known case to date, Sakura Syndrome is noted as when a Looper's personal morality moves at such right angles to reality that they feel they have the ability to do anything they want to anyone they want. Such things are often rationalized by arguments such as "There is no permanent damage," or "They won't remember this anyway," due to the Loops reset.

This is an extremely dangerous thing, as the affected often do not note the difference between "friend" and "test subject", be they Looping or no. Loopers who have Sakura Syndrome are at high risk for turning into a MLE. Any Looper who is suspected of having Sakura Syndrome is to be treated with caution.

Due to Sakura Syndrome's wide varieties there is no one accepted method for having to deal with the Syndrome. One method is for the patient to have a truly open heart-to-heart with themselves. One of the best known places for this is the Persona world.

Loopers can also self medicate against Sakura Syndrome by being aware they are at risk for it. Anakin Skywalker is known to be one of these loopers.

Malon: Breeds many different Cucco variants. Has offered at least one looper the chance to see a Charizard/Cucco hybrid and created a non-dangerous Death Stalker in a Naruto Loop.

Trixie: Mild Case focused around creating more and more powerful explosives, once suggesting to Twilight Sparkle they should create a double Big Bang. Has since recovered.

Medic: According to the Spy, Team Fortress 2's Medic has contracted Sakura Syndrome. However, according to Spy, this isn't too far from his normal personality. Whether he has recovered or not is unknown.