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Our study negatively correlates expression of PHLDA1 and Aurora A (zeige AURKA ELISA Kits) in IMR-32 cells and sheds new light on functions of PHLDA1 in the neuroblastoma (zeige ARHGEF16 ELISA Kits) tumor cells, suggesting its role as a pro-apoptotic protein

Suggest decreased expression of PHLDA1 may play an important role in tumor progression, and may become a new adjunct biomarker in the prognosis in gastric adenocarcinoma.

Data suggest that high PHLDA1 expression is controlled through an ER-NFkappaB (zeige NFKB1 ELISA Kits)-miR (zeige MLXIP ELISA Kits)-181 regulatory axis and may contribute to a poor clinical outcome in patients with ER+ breast tumors by enhancing stem-like properties in these tumors.

PHLDA1 expression is a useful addition in differentiating trichoblastoma and basal cell carcinoma.

A role for PHLDA1 as an apoptosis suppressor in oral cancer cells.

Data show that downregulation of aurora A kinase (zeige AURKA ELISA Kits) by the therapeutic antibody is associated with decreased levels of MYCN (zeige MYCN ELISA Kits) protein in cytoplasm, and induced expression of PHLDA1 and P53 (zeige TP53 ELISA Kits) proteins.

The follicular stem cell marker PHLDA1 (TDAG51) indicates that most basaloid tumors in nevus sebaceus are basal cell carcinomas and not trichoblastomas.

TDAG51 has a protective role in oxidative stress-induced (zeige SQSTM1 ELISA Kits) cell death in mouse embryonic fibroblasts.

Our results suggest that the balance between the cell survival and death signals mediated by HSP70 (zeige HSP70 ELISA Kits) and TDAG51, respectively, may be disturbed by the altered expression of HSF1 (zeige HSF1 ELISA Kits) during the progression of disease in this amyotropic lateral sclerosis model.

TDAG51 is involved in energy homeostasis at least in part by regulating lipogenesis in liver and white adipose tissue.