@inproceedings{kim2007,
author={Noh, In Sup and Choi, Kui Won and Kim, Sung Won and Nam, Yun Sik and Min, Yeon Jin and Kim, Jong Ho and Kim, Kwang Meyong and Kwon, Ik Chan},
title={Release Profile of a Model Protein Drug Depending on the Stability of Microspheres Based on Polyelectrolyte Complex },
year={2007},
month={7},
volume={342},
pages={505--508},
booktitle={Advanced Biomaterials VII},
series={Key Engineering Materials},
publisher={Trans Tech Publications},
doi={10.4028/www.scientific.net/KEM.342-343.505},
keywords={Alginate, Polyelectrolyte Complex (PEX), Protein Drug, Chitosan (CS), Controlled-Release},
abstract={Stability and disintegration of natural polyelectrolyte complex microspheres for protein
drugs delivery have been extensively investigated because of their great influence on the drug
release patterns. In this study, we tested stability of microspheres with alginate (Alg) core layered
by either chitosan (Chi) or glycol chitosan (GChi) by examining release profiles of fluorophorelabeled
bovine serum albumin (BSA) and lysozyme (Lys) from the microspheres. While GChi shell
was disintegrated quickly, Chi-shell microspheres showed good stability in PBS. Disintegration of
the coated layer induced the core material instable. The results indicated that while the charges of
the shell material provided additional diffusion barrier against the protein release, the key factor to
hold the proteins inside the microspheres was the integrity of the outer coating layer.}
}