Clenbuterol users will usually tailor their dosage individually, depending on results and side effects, but somewhere in the range of 2-8 tablets per day is most common, it is often stacked with cytomel. For fat loss, Clenbuterol seems to stay effective for 3-6 weeks, then it's thermogenic properties seem to subside. This is noticed when the body temperature drops back to normal.

The widely touted stack (ECA) of ephedrine (25-50mg), caffeine (200mg) and aspirin (300mg) is shown to be extremely potent for fat loss. In this combination, the ephedrine and caffeine both act as notable thermogenic stimulants. The added aspirin also helps to inhibit lipogenesis by blocking the incorporation of acetate into fatty acids. The athlete will be sure this stack is working by noticing an increase in body temperature, usually a degree or so (not an uncomfortable raise). This combination is taken two to three times daily, for a number of consecutive weeks. It is discontinued once the user's body temperature drops back to normal, a clear sign these drugs are no longer working as desired. At this point increasing the dosages would not prove very efficient. Instead a break of several weeks should be taken, so that this stack may once again work at an optimal level.