Collection of Blood for Multiple Collaborative Studies

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All subjects will be asked detailed questions about their current health status and current sexual and drug use behavior. HIV positive subjects will additionally be asked specific to HIV-related conditions and treatment. [ Time Frame: Ongoing ]

Collection and Preservation of Blood and Serum Specimens From HIV Positive or HIV Negative Patients for Multiple Collaborative Studies

Brief Summary

This study seeks to confidentially collect blood from HIV-positive individuals and HIV-negative controls to provide basic scientists with specimens for collaborative studies.

Detailed Description

HIV positive patients are currently the focus of multiple collaborative research studies, both at UCSF and other institutions. The aims of these research projects include improving the understanding of etiology, immunology, epidemiology and treatment of HIV. There are numerous requests from basic scientists at UCSF for collaborative studies on specimens, especially for blood, saliva and urine samples. Specimens may be used to test such things as virus characteristics, genotyping and/or phenotyping resistance, plasma drug concentrations, immune function or evidence of complications of HIV disease. The samples may also be tested for genetic factors that may be related to the course of HIV disease

Study Type

Observational

Study Design

Observational Model: CohortTime Perspective: Prospective

Target Follow-Up Duration

Not Provided

Biospecimen

Retention: Samples With DNA

Description:

Plasma, PBMCs, buffy coat, serum, saliva, urine

Sampling Method

Non-Probability Sample

Study Population

Subjects will be selected based on positive or negative HIV antibody, depending on the study for which blood is being collected. Patients will be chosen from the Positive Health Practice populations at SFGH and UCSF, the General Medicine Clinic at the San Francisco Veterans Affairs Medical Center. HIV uninfected healthy volunteers with comparable risk factors to the HIV positive subjects will be recruited from the community.

Condition

HIV

Intervention

Not Provided

Study Groups/Cohorts

HIV Positive

HIV-1 positive subjects

HIV negative subjects

HIV-1 seronegative control group

Publications *

Not Provided

* Includes publications given by the data provider as well as publications
identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.

Recruitment Information

Recruitment Status

Recruiting

Estimated Enrollment (submitted: April 15, 2011)

2000

Original Estimated Enrollment

Same as current

Estimated Study Completion Date

January 2020

Estimated Primary Completion Date

January 2020 (Final data collection date for primary outcome measure)

Eligibility Criteria

Inclusion Criteria:

HIV-1 antibody negative with similar characteristics to HIV-1 positive cohort

HIV-positive subjects naive to antiretroviral therapy

HIV-positive subjects stable on or off antiretroviral therapy for a minimum of 6 months