5 [micro]g/kg/h, dexmedetomidine provided more effective sedation as demonstrated by the need for fewer bolus doses of morphine, a decrease in the 24-hour requirements for supplemental morphine, as well as a decrease in the total number of assessment points with a Ramsay score of 1 (inadequate sedation) and the number of patients who had a Ramsay score of 1.

Each subject received a single subcutaneous bolus dose of 10 mg (healthy subjects) and 5 mg (critically ill patients) of oxycodone injected over one minute through a 27 G needle sited in the subcutaneous tissue just below the clavicle.

Information concerning dexmedetomidine included the indication for its administration, the initial bolus dose (if used), the initial infusion rate (if used), changes in the infusion during administration, duration of administration, and adverse effects that could be attributed to the medication.

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