Hemoglobin 4.2 mg/dL due to Autoimmune Hemolytic Anemia

A 51-year-old female has had fatigue, weakness, and shortness of breath (SOB) with exertion during the past 4-5 days. She called her primary care physician (PCP) who recommended that she had her hemoglobin checked. He called her back with the results, and told her to go to the emergency room (ER) for further treatment of severe anemia. On admission, the patient denied abdominal pain, chest pain, congestion, nausea/vomiting/diarrhea/constipation (N/V/D/C), dysuria, headache, chills, hemoptysis, neck pain, rash, or sore throat.

Her symptoms were exacerbated by activity and relieved by rest and laying supine. She also felt palpitations intermittently.

The patient was admitted to a regular medical floor and a hematology consult was called. The direct Coombs' test was reported as positive.

The CXR and CT scans were negative for neoplastic disease.

The patients has autoimmune hemolytic anemia (AIHA) mediated by warm antibodies because the hemolysis is observed at normal body temperature. By contrast, in the cold antibody AIHA, the autoantibodies attack the red blood cells only at temperatures significantly below normal body temperature, e.g. when working outside in the winter.

Would you transfuse this patient?

The hemoglobin was 4.2 mg/dL and if the patient was symptomatic. A blood transfusion was indicated.

In general, it may be difficult to find compatible blood in AIHA because of the presence of autoantibodies. RBC transfusions are generally avoided unless absolutely necessary.

74 comments:

I was also diagnosed with warm auto-immune anemia and after three months of illness have finally reached a hemoglobin level of 11.2. Prednisone did not help nor did removing my spleen.Rituximab saved my life.I also had a hemoglobin level of 4.2.I'm glad its all over with.

Also diagnosed with Idiopathic Auto-Immune Hemolytic Anemia. Went to the ER with Hg of 63 (normal range 140-180). No luck with 3 months of Prednisone (except future side effects I'm sure) and splenectomy didn't "fix" the problem. IG IV treatments help, my Hg has stabilized, but not fully cured. Western medicine... anyway, trying some acupuncture and other ways to remedy the problem.

My father has aiha and his hgb level was terribly low also.He is currntly on Prednisone and just had his 6th rbc transfusion.Dr. wants to remove his spleen next.I will ask the Dr.about the human (cd20) clusters of differentiation molecules and see if my pops can skip that splenectomy stuff altogether.Anyway,I appreciate this site and your peoples feed back!I hope it works out well for him.

Diagnosed with Autoimmune haemolytic anemia 6 months ago. Placed on prednisone.After hematologist tried decreasing the dosage the blood started hemolising. Hb had dropped to 3.5 now it is 9.0 after transfusion.No particular reason given for Anemia. interested in knowing whether joint pains and swelling can involve anemia?

Hi,Does anyone out there have Idiopthathic Autoimmune Haemolytic Anaemia with a Negative Coombs?I have been on Prednisolne for 2 months when blood dropped to 4.Now they are weening me off the Hb is starting to drop again. Rituximab is the next step, anyone been on it?

I have Coombs negative hemolytic anemia. No response to prednisone or Rituxan. Doctors say there is no good argument to take out my spleen because they haven't found the cause of my hemolysis. I've had at least 70 transfusions in the past 3.5 years and usually have a hemoglobin of around 9. We transfuse at 8 now but I used to be able to hold off till I was in the 7's. I'm tired, anyone else? I'd love to find out where you're at now. DaraCeridiagirl@yahoo.com

I am writing this from a chemo clinic, in which I am now receiving my 4th Rituxan treatment. After approx. one month, 4 transfusions, treatments, and a recent discovery of a blood antibody I am starting to worry. Hematologist has recommended Splenectomy after HGB levels continue to drop average of one point per 4 days -- currently at 6.8. Anyone receive cytotoxin before the splenectomy?

1 month ago Dx with Aiha hgb 4, im 28 did not respond to prednisone, or Iga then went to Rituximab X4, with little resulsts by 3rd dose hgb down to 5, back to hospital they took my spleen- laperscopically(3 1in incisions) quick recovery, 2 weeks later incisions basically healed and getting around like normal, hgb now 13-almost normal! hopefully I won't drop again dont want to go on to the bigger badder chemo drugs

Diagnosed back in March 07 with AIHA. 5 blood transfusions and 6 months of predinisone, still sick.Started Rituximab last week, have 3 more treatments and hoping it will work. Can't remember the last time I felt well. Have had all the tests to rule out any underlying diseases. Bone marrow biopsy the worst test. Lowest hemoglobin 5.6, highest 11.3 over past 6 months.

a patient suffering from AIHA is being treated with mild doses of dexamethasone 8mg a day there is an improvement of Hb from 5.6 to 7.0 but she has the problems of gastritis and constant increase of liver enzymes can u say what could be best for her

I have warm AIHA and have twice had Rituximab - last time because Hgb dropped to 5, I had pleural effusions and circulating sepsis - rsulting in peri-arrest. Rituximab prescribed whilst I was still on 60 mg of prednisolone daily. My Hgb level now 14.3 (!!!personal best) and pred. stopped. Rituximab works well for me and I have no side effects which is lucky as I have 2 other auto-immune problems!

I have this too. Have been at 3.5 hg twice. I too cant remember the last time I felt well. Currently have lost a lot of my life and support systems because people around me can't live with this illness going forward. Any daily routine measures that can make me feel better?

My brother was diagnosed with Autoimmune hemolytic anemia as a small child, 3 years old. They tried steriods. They did not work. They then removed his spleen and everything was fine. He went into surgery white as a sheet and came out with color. I thought that children only got this and it was very rare. I'm very surprised to see that adults are getting this and spleen removal is not working. I'm wondering if my brother's will come back? He still has his blood checked once a year and so far he is fine.And they did think when he was young that his liver could start doing what his spleen did???

I am sick and tired of being sick and tired . . . diagnosed spring 07 with cold hemaglutinin syndrome-- hemoglobin ranges from high 90s down to 50s. Started with plasmapheresis and transfusions, and found that IVIG helped to keep the wolf at bay for 6-8 weeks at a time. When I get sick, I really get sick, and require the whole kit and kaboodle to bring me back. Next, is the rituximab--should I write my will? JR--Hamilton, Ont.

My daughter had AIHA at 2 months of age. After about 20 transfusions in 3 months, prednisone (which didn't do anything) and finally cellcept (which is also used for organ tranplant patients-stops the immune system from rejecting the organ, basically shuts it down) she recovered. No official cause for the illness or the recovery (she's 4 years old now). I believe, and her hemotologist finally admitted as a possibility, that it was due to her body's response to getting a pertussis (whopping cough) vaccination while she had a slight respiratory illness (a cold). My other daughter (6 mo.) has been fine, but has not and will not get the pertussis vaccination. The drs. say I have no reason to believe the AIHA will ever come back.

Diagnosed Feb 07, was down to 5.2, initial treatment was blood transfusions received 16 in total (I live in Spain) developed pneumonia within hours of being in observation, was diagnosed possible mycoplasma. Received antibiotics and 120mg of prednisone. Levels didn't go further than 9.0 hg, so then wen ton to receive 19 sessions of plasmapheresys... am now on 150 mg of azatioprine and 5mg of folic acid, came off pred, but have had 2 set backs since then. Have been good for 2 months now without blood tests, it's the longest I've been feeling well.

Drs told me my AIHA will always stay with me and we are only keeping it at bay, trying to save my spleen. I'm only 29, but if I didn't take my aztioprine I would die. I have written my will, planned my funeral. the most menacing me for me is any infection in the lungs as they are very weak. This illness has taught me every day is a gift. I am very grateful to my hematologists 4 of them, they have spent months trying to control it as I don't follow any logical patterns neither am I cold or warm or have had anything that could have caused this, I know they spent and amazing amount of money on me and yet they treat me like my case is personal to them. View my blog, click on my name!!!

I have AIHA (warm) and am doing well after 6 months of treatments. I have had my gall bladder removed, and got worse. My hgb dropped to 4.6. I have recieved gammo globulin, vincristine and retuxen. Also, 5 units of blood and lots of cancer scares. I was on 80 mg. of steroids per day for 4 months. I'm off of them as of yesterday. I hope I remain healthy. I am sick and tied of being sick and tired. People look at me and can't see anything wrong and wonder if it's all in my head. My doctors are great and I hope to remain healthy. INDIANA

Hi,I was diagnosed with warm AIHA last december with Hgb at 4.0. I was wondering if any of you had their teeth whitened or bleached? I believe there is a correlation here, the ingredient in these products are either carbamide peroxide or hydrogen peroxide. I relapsed twice and I remember bleaching my teeth around that time and also once shortly b4 first diagnosis. I'm having my spleen removed tomorrow, and hopefully that takes care of the problem.

I've had IAHA since I was a child, now 30. Steroids are no good, rituximub didn't work. Immunuglobulin with cyclosporin seems to work but after 6 months IAHA was back again and the side effects to the immunuglobulin have been horrendous, they are now suggesting removing my spleen, any one got any info on success rates if I were to proceed with this course of action (my options are now very limited)

Its strange but the comment made about teeth whitening is very familiar. I got ill soon after using a teeth whitening pen..... it may just be a fluke. I dont think it has anything to do with it. I went on holiday to USA and got bitten all over my feet. I am wondering if this had anything to do with it?. I have been ill for 4 years now and I am 26 years old. I am on Azathiroprine 100mg per day. I used to be on steroids and that made me feel awful. My blood went down to 3.5 and I was made to walk to a hospital in London! by doctors. I have had several operations - gall bladder removed - endoscopy and sphincterontomy. I am basically being kept alive by my drugs at the moment. Drs just dont know what is causing it or really how to cure it. There is no diagnosis. My Coombs test was negative as was bone marrow. After having two bone marrow biopsies,still remained negative. Has anyone else got any idea what this may be or any cure? or have you got this?. I am desperate to get back to a normal way of life.

My son became very ill with severe onset of AIHA [3.8 hg] and enlarged liver/spleen; indirect bilirubin was 4.1. He was perfectly healthy and breastfed. this came 3 days after his vaccinations and I believe it was due to the vaccines. After 8 mo. of pred and IVIG therapy and one transfusion, he was Coombs negative and never suffered another relapse. Anyone out there with a similar story?

Hi, i was recently diagnosed with autoimmune hemolytic anemia. I'm 23. I was down to heamoglobin level of 26 when i was admitted to hospital last 3 weeks. Normal count would be in the range of 115 - 155 g/L. I was in hospital for a week. Had 5 bags of blood transfusion and heaps of Octagams. Been out of hospital for nearly 3 weeks but have blood tests twice weekly as doctors are monitoring my blood level but blood count seem to drop everytime. My recent blood test was at the count of 80 and all of the anemia symptoms came back (severe headache-thumping in the head,nausea,fatigue,dark urine...) so yesterday I received Octagam drips (Immunoglobulin) of 150ml. I'm currently on Prednisolone (50mg) and Acid Folic supplements and just yesterday my doc has prescribe me with Azathioprine since the Prednisolone didn't seem to work. I didn't think that this blood disorder was that serious but after some research and reading it seem to be pretty serious. I'm also terribly worried bout the side effects of the drugs and medical treatments, internally, physically and emotionally. Can anyone out there comment on their experiences.

I also have autoimmune hemolytic anemia. I was admittied to the hospital 6 weeks after my son was born with a hemoglobin of 2 and continued to drop. I have tried prednisone, cellcept, and now trying Azathioprine. So far nothing has worked I havent met anyone with both cold and warm antibody autoimmune hemolytic anemia. I'm very concerned and just wondering if anyone else is in my shoes??? Along with all this I also have Lupus,high blood pressure,hypothyroidism,and Rheumatoid Arthritis everything but the thyroid issued occurred after the anemia started.

If anyone could point me in the right direction for my fathers sake I would greatly appreciate.

My father has been diagnosed with a severe cold anitbody. We live in one the hotest states there is, Louisiana. Since being diagnosed in August, my father has had over 40 transfusions, his count got down to 3.9 at which point he coded in the emergentcy room. His iron levels are so high, he is now on Exjade to reduce iron levels. His doctors say there is nothing that can treat the cold antibody.

I just want to know is there anyone that has any success with any kind of treatment for this disease. Please let me know.

My email is thmarine1@yahoo.com if you have any advise for us. He has warm AIHA. Docs want to try cellcept and I'm so scared about the side effects. I can't find a support group or info on this terrible problem. I really need some help!

I had surgery on a perferated duodonal ulcer and my hemoglobin went down to 4.2. It went untreated and I suffered hearing loss from nerve damage to my left ear. When I saw my regular doctor after being released from the hospital he ordered a CBC. My hemoglobin count was 9. He put me on iron. My hemoglobin count is normal now, but I will probably never regain the hearing in my ear.

My 15 year old daughter was diagnosed with AiHA last year. She has been on prednisone for quite a while. We are switching to 6-MP because of some serious mood problems that might be added to because of the prednisone. I would love to connect with others that can share their experiences.

I was diagnosed with a mixture of both warm and cold antibody strains (how, I don't know) of AIHA in 2003, when I was 16. Was nearly comatose when I went to the ER. Had a hemoglobin of 32 (Australian measurements. . /extremely/ low). Was treated with blood transfusions and prednisone. I had a splenectomy (unsuccessful), as hemolysis would flare up again whenever we tried to wean down the prednisone. I was eventually treated with MabThera, and made a slow recovery. I still have very minor hemolysis, but it's slow enough that it doesn't affect me.

I am a 76 yr female. Diagnosed with Myelodysplastic Syndrome,Autoimmune Hemolytic Anemia, Severe Neuropathy and Rheumatoid Arthritis. Have been RBC transfusion dependent since 2003 (2 units/mo). RBC transfusions becoming difficult because of autoantibodies making it difficult to find compatible blood.Hemotologist is recommending a splenectomy. I just don't feel that it will help and will still need the transfusions. If anyone has the same problem--transfusions hard to match and have Autoimmune Hemolytic Anemia. Did splenectomy help?

Previous postI've had IAHA since I was a child, now 30. Steroids are no good, rituximub didn't work. Immunuglobulin with cyclosporin seems to work but after 6 months IAHA was back again and the side effects to the immunuglobulin have been horrendous, they are now suggesting removing my spleen, any one got any info on success rates if I were to proceed with this course of action (my options are now very limited)

UpdateI had my spleen removed 8th March by key hole surgery, the operation went well, so far my HB has stayed at no less than 12 which is amazing. I will be completely off Cyclosporin hopefully next week, have my fingers well and truely crossed that this is the cure!

I am a male (48) who was taking simcor for about 6 months and tylenol when i felt a cold comming. I began seeing my urine dark and climbing stairs made me dizzie and felt tired. was diagnose AIHA (WARM) Had two blood transfusion now in my house taking prednisone 80 mg a day its been 4 wks.and when i got out of the hosp. was 7 Hemoglobin count each wk it goes up one point now i am at 8 doctor tells me after 6 wks they will lower the dose and see how the body reacts. hoping for the best! Ricky from Puerto rico.

Hi,I'm a 51 yr old male, with Coombs (DAT) Negative AIHA since early 2005. Tried almost every treatment - Pred, Danazol, Cellcept, 12 Rituzan infusions -nothing helped. I dreaded this but finally had my spleen removed June 3. HGB went from 7 to 12 in 12 days... Feel so good, first time in four years. Running again, hitting the weights. Hopefully, will be this way for the rest of my life. For anyone suffering from AIHA, I highly recommend splenectomy. Ernesto

Male, 35, began having autoimmune events since 1998. After all these years of treatment mainly with prednisone and having had splenectomy in 2001, last October my hgb dropped to 4.2 and had to rush to the ER. IV prednisolone shots and dexamethasone began working three days after, but the final treatment was Rituximab (two infusions in one month). Dong well right now, hope the effect lasts another 10 years!

I'm a 36 year female who has been dealing with IAHA for 2 years now. I never had the chicken pox so in 2005 I had the varicella vaccine. A few days later, I broke out in a rash that never went away. I still have it on my arm and it only stays in one little area. I know the hemolytic anemia developed from this vaccine and knew at the time I should not have received it but did it anyway. I went up and down on the prednisone and finally found an great physician who knows how to treat me. In Feb I completed four rounds of Rituxan and have been on 7.5mg of prednisone. I feel good but always worry my HGB will drop again.

I'm just wondering if their is anybody who had hemolytic anemia and on low doses of prednisone who have become pregnant. My physician told me it should be fine but I am very afraid to become pregnant with a autoimmune disease? Thank you!

My mother has AIHA and she is 83. She has had apx. 5 transfusions, immune globulin therapy, and is now on 30 mg of prednisone per day. Her hemoglobin is now 7.3. After she goes off the pred. they want to give her Rituxan. Does anyone know of anyone that is elderly that has received this drug? Have any of you that have had this treatment gotten sick from it? I'm so afraid it will be too hard on her. Appreciate all comments.

i am 43 year old female, i have had AIHA since i was 17. i had a splenectomy when i was 19. all seemed quite good for a few years, then i had a relapse. since i have had a number of relapses. i have tried prednisolone, azaphiaprine,cyclophosphomide,immuno globulin,i am now on my third 4 week dose of rituximab,as i relapsed over christmas,spent new year having a blood transfusion.

Had autoimmune hemalytic anemia 5 years ago. Hemoglobin was at 4.2. Was given 3 transfusions then on/off with prednisone. Did 4 treatments of Rituxan. After 3 years my hemoglobin was up to 12.0. Last October hemoglobin was back down to 4.0. On prednisone again. We'll see how I do on that. If it starts going back down again, may have to do the Rituxan treatments again. Can't figure out why this is happening.

AIHA is a fluctuating disease process with the activity of the condition going up and down as the time progresses. This explains some of the unpredictability in the variations of your hemoglobin level.

Previous postI've had IAHA since I was a child, now 30. Steroids are no good, rituximub didn't work. Immunuglobulin with cyclosporin seems to work but after 6 months IAHA was back again and the side effects to the immunuglobulin have been horrendous, they are now suggesting removing my spleen, any one got any info on success rates if I were to proceed with this course of action (my options are now very limited)

Update 1I had my spleen removed 8th March by key hole surgery, the operation went well, so far my HB has stayed at no less than 12 which is amazing. I will be completely off Cyclosporin hopefully next week, have my fingers well and truely crossed that this is the cure!

Update 2Well it's a year since my spleen was taken from me and so far so good. I've been battling this disease since I was 8 years old and I am trying not to believe too hard it's actually gone away for good just in case - but a whole year no medication and healthy I just can't believe it!

my 11 year old was diagnosed with warm AIHA and a hemoglobin of 4.2. he was transfused and started on prednisone; down to 35 mg right now. his hemoglobin is up to 13.9 but his retic count is going up and down from 2.0 to 3.0. so they are now thinking of metacapuline or rituximub because they are afraid they can't safely reduce his pred and they don't want to keep him on it longterm (it has been 4 mos) did any of you have your retic count go up and down like this? and did the pred eventually work without the cancer drugs?

23 years old, have aiha for quite some time (3-4y) (together with 3-4 other diagnoses, something like sle in obs, aps, high blood pressure) Been on 96 mgs of steroids for months, now back to 4 mg after 2 years, horrible stuff, got osteoporosis and a lot of other things, taking approximately 6 pills a day,gained about 20 kgs)dont know the count for blood stuff, i dont worry about that....the thing i want to say is that we all have to be strong and fight it, think positive, take a little more care for yourself...everybody has different issues and i think and have been said that there is no cure for this disease but you can live more or less normally entire (long) life...just (try to) be happy because stress is todays mass murderer...peace out

Was diagnosed with IAHA in Aug 2007. After 21 units of blood, splendectomy, chemo ( cytoxin & Rituxan) recovered and was normal for 2 1/2 years. June 2010, my hemoglobin started falling and I was given a dose of cytoxin & rituxan and 2 units of blood. A CAT scan showed that my spleen had regenerated/or had an accessory spleen. Removed the splenetic tissue and the tip of my pancreas and blood is back to normal. Now I am trying to recover from the surgery and drugs. Grateful to be alive.

I'm 53yrs old,I be diagnose with AIHA since 1995.I nolonger have a spleen gone in 1996,did predisone a year prior to surgery at 80mgs.I lasted elevan years no problems and they it in Sept 2007 it kicked back in.FRom Sept2007 to the end of July 2008 test where done and predisone started at 100mgs four times a day.The end result was I have multi myeloma,bone marrow cancer.After that six treatments of cytoxan was done the cancer is dorment,but it's there for the rest of my life.I just got predisone again,off and on since 2008 till now 2011.Need to try alterive sources.natural would good like the chinese have done for thousand of years.Still kicking will not give up.

Hi all, was diagnosed with IAHA on the 14th jan,2011, my Hg was at 42, admited in the hospital 7 days given 4 units of blood , and put on 85mg prednisone, two weeks later my HG is at 72, and told I am not reacting to the prednisone, given two options A) remove the spleen, or B) Rituxan, opted for rituxan, have had three treaments, my HG is at 106, and most important is the prednisone that we have taperd back to 30mg starting Friday. Have had no side effects with the rituxan........will keep u posted.

Oncologist trying to figure out what have. Now think it might be Coombs negative automimmune hemolytic anemia.

Here is the thing: I have low oxygen levels and have a oxygen tank 24 hours a day. My oxygen level with the tank is approximately85%. Doc doesn't think the oxygen level has anything to do with the anemia diagnosis.

It's unusual to have hypoxia (low oxygen level in the blood) with anemia, unless the anemia is extremely severe, for example, Hgb lower than 4 mg/dL. Check with your doctor and a pulmonologist (lung doctor).

You can saturate your lungs or blood with oxygen, but if you don't have Red Blood Cells to acquire and transport the blood you will have anemic symptoms and signs. The actual liquid blood can carry about 20% oxygen dissolved within itself. RBCs take care of the rest.

50 year old male diagnosed with AIHA a little over three years ago. Started on Huge doses of Prednisone followed by six rounds of Rituxan. Numbers improved from 7s to 12s along with a reduction of steroid intake to 4mg a day. Stayed pretty constant for about two years but now I'm back to feeling awful. Hemoglobin numbers are back to below 9 and falling. Doc has not prescribed additional steroids (which I don't understand) but has put me back on Rituxan. I'm now two treatments into a six treatment course. Still feel awful. Doc is pushing for a splenectomy but I'm fighting that every step of the way. It is my belief that this was caused by large doses of Lyrica that were prescribed to me following a spinal fusion. anyone else have a similar experience?

My son who is now 12 has had this since he was 15 months old. We took him to the hospital because he was not feeling well and found out his HGB was 2.4. They tried everything! His body was going through blood transfussion every 6 hours. Chemo was what finally stopped it for him. After 6 months in the hospital he hasn't had any issue till this year. He had his galbladder out in January, now he's got some pain in his chest area from the portacath he had when he was little. For anyone who has this, it doesn't go away. My son has stayed in the 12 area for HGB for years but we are having to deal with all these other things that are coming up because of his AIHA.

I'm 22 years old. Was diagnosed with hemolytic anemia in Sep 2011. Hgb of 4. Got put on prednisone, Received 6 blood transfusions, hgb went up, and they began to wean me off prednisone. AIHA came back, had to receive two more blood transfusions, was put back on high doses of prednisone, dec 2011 everything looked great, began weaning me off prednisone and here I am 1/9/12 receiving two more units of blood. I got a new hematologist and she will put me on rituxan. She said if that does not work, removal of spleen is next. What a nightmare. I feel for you all and pray our doctors have wisdom and that we will be healed.

I'm 40 years old. I was diagnosed with AIHA December 2011. Hgb of 6.8. I was put on 120mb of prednisone until my hgb came back to normal. The hematologist started reducing the prednisone after that and my hgb started to drop at or around the 60mg dose. I did 4 weeks of Rituxan. I seemed to feel better during the Retuxin and my hgb levels remained stable around the 11.8-12.4 on the hgb. Now, it has been a little over 2 months since the last Retuxin treatment and my hgb is 12.2 with a 50mg dose of prednisone. I'm scheduled for surgery to have my spleen removed, but the Hematologist said he will cancel it if my blood tests continue to improve. Has anyone else had about the same ups and downs with their hgb levels? I get my blood checked weekly, and it seems like a roller coaster ride. How long after Retuxin treatments has anyone noticed improvements in there blood tests?

I too am a sufferer of Idiopathatic(no known cause) Autoimmune Hemolytic Anaemia. Mine started after I contracted Glandular fever aged 48. How many of you sufferers had a virus/infection/stress prior to your diagnosis? It would be interesting to see if there may be a connection. They have no idea why I got it, but I feel the Glandular fever triggered it. Would love to get your feedback. Many thanks and stay positive

My son was diagnosed with AIHA and relapsed several times after viral illnesses. His hgb usually drops slowly over a week or two but last time he had fever,weak and tired on Sunday and hgb dropped to 5 by Mon. night. On the positive side he responds well to Prednisone with few side affects.

February 2013 diagnosed with Hemolytic Anemia at age 34. Coombs positive, with hemoglobin at 4.2. Received blood transfusion, and started prednisone 60mg. Started to taper off prednisone after hemoglobin reached 12. Was on 10mg prednisone every other day, when my hemoglobin dropped from 12.5 to 8.5 in 2 weeks. Started back up to 60mg. Hemoglobin dropped to 7.5, and I received another blood transfusion. Hemoglobin went up to 9.2. Starting first dose of Rituxan tomorrow, very hopeful this works so I can get off of the Prednisone.

I had AIHA last year and did I know it. I was in hospital 6 weeks and had 27 pints of blood and other medication. 18 months later I am feeling fine and all is well when I go to the hospital every 6 weeks for a check up.

I am a 48 year old female and in July 2013 I went to ER--very ill with all the symptoms. They discovered a Hemo level of 40, and I was in hospital for 10 days/12 blood transfusions. I was put on Prednisone [high dosage] but when I got home and read about the drug, I no longer wished to take. I did research and found that Tumeric is as powerful as some of these big-gun drugs. So I told my doctor I was stopping. I used a tsp of turmeric mixed in juice, milk--3 times a day. And I power-ate super nutritious food-blueberries, greens, etc. I also made a juice of Asian Dates (12 medium sized dried fruits in a big jar of boiling water. Let it brew for a day or two. I drank a jar full every day. You can find these in Chinatown as it is an age-old tonic to help build blood.[Try adding fresh ginger and goji berries for more taste and benefit. I recovered completely without more drugs and surgery. My hematologist was very sceptical and now she is very surprised and pleased. I have to take B12 forever, and currently taking iron because, although I have enough RBC, they are small.