Jegaskanda S. The Potential Role of Fc-Receptor Functions in the Development of a Universal Influenza Vaccine. Vaccines (Basel). 2018 May 17;6(2). Abstractsubmitted by kickingbird at 1 days ago from Vaccines (Basel). 2018 May 17;6(2) (via https://www.ncbi.nlm.nih.gov/pubmed/29772781)Despite global vaccination efforts, influenza virus continues to cause yearly epidemics and periodic pandemics throughout most of the world. Many of us consider the generation of broader, potent and long-lasting ...

Zheng Y, etc.,al. Comparative analysis of MicroRNA expression in dog lungs infected with the H3N2 and H5N1 canine influenza viruses. Microb Pathog. 2018 May 14. Abstractsubmitted by kickingbird at 1 days ago from Microb Pathog. 2018 May 14 (via https://www.ncbi.nlm.nih.gov/pubmed/29772263)MicroRNAs, a class of noncoding RNAs 18 to 23 nucleotides (nt) in length, play critical roles in a wide variety of biological processes. The objective of this study was to examine differences in microRNA ...

Ikematsu H, etc.,al. In vitro neuraminidase inhibitory concentration (IC50) of four neuraminidase inhibitors in the Japanese 2016-17 season: Comparison with the 2010-11 to 2015-16 seasons. J Infect Chemother. 2018 May 11. Abstractsubmitted by kickingbird at 2 days ago from J Infect Chemother. 2018 May 11 (via https://www.ncbi.nlm.nih.gov/pubmed/29759897)To assess the extent of susceptibility to the four most commonly used neuraminidase inhibitors (NAIs) in the viruses epidemic in the 2016-17 Japanese influenza season, we measured the 50% inhibitory concentration ...

Li Y, Sun L, Zheng W, Madina Mahesutihan, et al. Phosphorylation and dephosphorylation of threonine 188 in nucleoprotein is crucial for the replication of influenza A virus. Virology 2018;520:30-38. Abstractsubmitted by kickingbird at 4 days ago from Virology 2018;520:30-38 (via https://www.ncbi.nlm.nih.gov/m/pubmed/29775781/)Nucleoprotein (NP) is a major component of the viral ribonucleoprotein (vRNP) complex that is responsible for viral replication, transcription and packaging of influenza A virus. Phosphorylation of NP ...

Venkatesh D, Poen MJ, Bestebroer TM, Scheuer RD, e. Avian influenza viruses in wild birds: virus evolution in a multi-host ecosystem. J Virol 2018 May 16.. Abstractsubmitted by kickingbird at 4 days ago from J Virol 2018 May 16. (via https://www.ncbi.nlm.nih.gov/m/pubmed/29769347/)Wild ducks and gulls are the major reservoirs for avian influenza A viruses (AIVs). The mechanisms that drive AIV evolution are complex at sites where various duck and gull species from multiple flyways ...

Lu C, Yin Y, Meng F, Dun Y, Pei K, Wang C. Discovery of (E)-1-amino-4-phenylbut-3-en-2-ol derivatives as novel neuraminidase inhibitors. Bioorg Med Chem Lett. 2018 May 4. pii: S0960-894X(. Abstractsubmitted by kickingbird at 7 days ago from Bioorg Med Chem Lett. 2018 May 4. pii: S0960-894X( (via https://www.ncbi.nlm.nih.gov/pubmed/29748050)Neuraminidase has been considered as an important target for designing agents against influenza viruses. In a discovery of anti-influenza agents with epigoitrin as the initial lead compound, a series of ...

Alymova IV, McCullers JA, Kamal RP, Vogel P. Virulent PB1-F2 residues: effects on fitness of H1N1 influenza A virus in mice and changes during evolution of human influenza A viruses. Sci Rep. 2018 May 10;8(1):7474.. Abstractsubmitted by kickingbird at 7 days ago from Sci Rep. 2018 May 10;8(1):7474. (via https://www.ncbi.nlm.nih.gov/pubmed/29749408)Specific residues of influenza A virus (IAV) PB1-F2 proteins may enhance inflammation or cytotoxicity. In a series of studies, we evaluated the function of these virulence-associated residues in the context ...

Perot BP, Boussier J, Yatim N. Autophagy diminishes the early interferon-β response to influenza A virus resulting in differential expression of interferon-stimulated genes. Cell Death Dis. 2018 May 10;9(5):539.. Abstractsubmitted by kickingbird at 7 days ago from Cell Death Dis. 2018 May 10;9(5):539. (via https://www.ncbi.nlm.nih.gov/pubmed/29748576)Influenza A virus (IAV) infection perturbs metabolic pathways such as autophagy, a stress-induced catabolic pathway that crosstalks with cellular inflammatory responses. However, the impact of autophagy ...

Wang Y, Li J, Yan W, Chen Q, Jiang Z, Zhang R. An active component containing pterodontic acid and pterodondiol isolated from Laggera pterodonta inhibits influenza A virus infection through the TLR7/MyD88/TRAF6/NF?κB signaling pathway. Mol Med Rep. 2018 May 2.. Abstractsubmitted by kickingbird at 7 days ago from Mol Med Rep. 2018 May 2. (via https://www.ncbi.nlm.nih.gov/pubmed/29749442)The influenza virus is a pathogen that can cause pandemic and epidemic outbreaks, and therefore represents a severe threat to human health. Antiviral drugs have an important role in the prevention and ...