"Human" has received generally positive feedback from music critics, praising the composition, the musical influences, and the production. It became the third song by the band to enter the top 5 of the UK Singles Chart. It was their first top ten hit in the Netherlands (peaking at number 2). The song was released on a 7-inch picture disc throughout the world on various dates in November, with a B-side entitled "A Crippling Blow".

In an interview with Rolling Stone magazine's Smoking Section, Brandon Flowers described "Human" as "Johnny Cash meets the Pet Shop Boys". Flowers stated that the song was created with Stuart Price during their work with him on the Sawdust album, and has changed very little since then. He confessed to not putting it on Sawdust as "it was too good".[2]

The cover art for the single is a portrait of the band's guitarist Dave Keuning, and is one of the four portraits drawn by Paul Normansell for the album.

The earliest digital release of the song was missing a hi-hat section at the beginning of the song.

The song received positive reviews from contemporary critics. An interview in The Observer newspaper stated that the track "is a cross between New Order and Bruce Springsteen - that should please fans of 'Mr. Brightside'." Chris Williams of Billboard gave a positive review, echoing The Observer's description of "merging a Boss-like melody over a New Order-injected rave-up." He also praised the song for "stretching the soundscape of alternative rock, which has increasingly become difficult to differentiate between mainstream rock. With this amazing, heart-warming, soul-crushing song the Killers may have altered music history, or perhaps the history of mankind itself. Never has such a scrumptious buffet of postmodernism, 19th century Hungarian ethics , and falling rose petals been so beautifully presented."[3] Music Radar complimented the song in their review of Day & Age, saying "A gentle, phased, clicky guitar riff opens this gorgeous nod to the gentle side of '80s new wave."[4] Caryn Ganz with Rolling Stone gave the tune three-and-a-half stars, calling it "delicious."[5] "Human" was voted the Best Song of 2008 by the readers of Rolling Stone.[6]

In 2010, a vote by listeners to UK radio station XFM polled the song at #97 in their poll of the Top 1,000 Songs of All Time.[7] In December 2009 it was voted the 25th Best Song of the Decade by listeners of UK music station Absolute Radio.[8] In October 2011, NME placed it at number 144 on its list "150 Best Tracks of the Past 15 Years".[9]

There was confusion and debate over the line "Are we human, or are we dancer?" in the song's chorus due to its grammar.[11] Debate raged across the Internet over whether the lyric said "dancer", "dancers" or "denser", a misunderstanding which elicited conflicting interpretations of the song's meaning.[12][13] On the band's official website, the biography section states that Flowers is singing "Are we human, or are we dancer?" and also says that the lyric was inspired by a disparaging comment made by Hunter S. Thompson, who stated that America was "raising a generation of dancers".[14][15] From an interview:

Flowers is irritated that people don't quite seem to get the lyric, and that fans were unhappy with the song's dance beat. "It's supposed to be a dance song, it goes with the chorus," he says. "If you can't put that together, you're an idiot. I just don't get why there's a confusion about it."

In the US "Human" debuted at number 13 on Billboard's Hot Modern Rock Tracks chart, and peaked at number 6.[18] It is the band's sixth top ten hit on the chart. The song debuted and peaked at number 32 on the Billboard Hot 100 on the chart week of October 18, 2008,[19] giving the Killers their third top 40 hit there. It reached number 3 on the UK Singles Chart and in 2012, BBC Radio 1 announced that it was the 39th most downloaded song of all time in the country.[20]

The music video for "Human" was released in mid-October 2008 and directed by Danny Drysdale.[27] It features the band performing the song in Goblin Valley State Park, Utah. The portraits of the band drawn for the album by Paul Normansell are shown in the video, such as when the band members hold the portraits in front of their faces.[28] Various animals are also shown throughout the video, such as a white tiger, an eagle, and a cougar. It's been noted to have heavy similarities to Pink Floyd'sLive at Pompeii concert film, such as the band playing the song in a desert landscape amongst various amplifiers and other stage equipment and mostly in much of the camera angles. The video ends with the band watching the sun setting in the desert, which turns into the album cover, also drawn by Paul Normansell.[29]

The song was used for the Spanish television station Telecinco for the "ad" of the 2010 FIFA World Cup Final. The motto was "Una final no se juega; una final se gana" (A final is not played; a final is won).[30]