Season Five opens with the team still dealing with the aftermath of the battle in Washington. Julie wakes up from her coma, but Tasha does not. Steve temporarily loses his powers when an EM pulse hits L.A., and Julie's sister, Emma, moves in with them when their parents die in a plane crash. This year, the team is recruited by the LAPD and works as an elite division of the force.

Also this season, the 100th episode brings Tasha out of her coma, and as she deals with the consequences of her actions, she decides to leave the team.

The main threat this season is Aramus Technologies and the new U.S. President, who unleashes Aramus's androids to wipe out all the tainted in the U.S. But the Aramis Artificial Intelligence becomes self-aware and turns on all humans, leading to a deadly showdown in the Aramus Tower where one member of the team will die.