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We are planning on heading to the East Coast late July 1019 for about 12 days. We are hoping to see NYC, the Hamptons, Niagara Falls, and up state New York and fine sh were th a couple of days in DC. In what order should we do this? Should we just get a car from either JFK or LaGuardia, do all of our sightseeing before getting into the city for a couple of days (this out second visit to NYC).

Since you're apparently returning to Vancouver, you may find it more convenient to return the car in Niagara Falls, NY and travel by bus or train the relatively short distance to the Toronto Airport for your return flight. In any event, price out this alternative.