ABSTRACT:Purpose: Chemotherapy-induced peripheral neuropathy (CIPN) is a important, severe symptom directly related to the administration of neurotoxin chemotherapy for the treatment of cancer. Peripheral neuropathy is the end result of peripheral, motor, sensory, and autonomic neuron damage secondary to neurotoxic chemotherapy agents. This investigation was to assess the effectiveness of care bundle approach on the level of CIPN and Quality of Life among patients receiving cancer chemotherapy. Method: A True Experimental Research Design , Simple Random sampling Design was used .A total of 120 individuals actively in chemotherapy treatment participated in this investigation. The participants were allotted to experimental and control group by Random table after meeting the inclusion and exclusion criteria. The EOQRTC QOL , LANNS, CTCAEV scale were used to assess the level of CIPN and QOL. Results: Revealed that Experimental Sensory ,Motor , Autonomous, Tendon reflex, Total score posttest 3 score was stastistically significant from control post test 3 score at (p=0.001 which showed that intervention is effective in improving the neuropathy. Regarding neuropathicpain, knowledge ,Quality of life ,the experimental score posttest 3 score was stastistically significant from control post test 3 score at (p=0.001) for all domains like functional scale and global Health Status. Conclusion: The intervention is effective in improving the Quality of life. In conclusion, this study has demonstrated that exercises (aerobic, strengthening, balance training, stretching) massage therapy are effective in reducing the level of neuropathy, improving the Quality of life, reducing the neuropathic pain and improving the quality of life.