The Cambridgeshire Handicap is a flat horse race for three-year-old and above thoroughbreds run over a straight distance of 1 mile 1 furlong (1,811 metres) at Newmarket's Rowley Mile course in late September / early October.

It is a handicap race and was first run in 1839. The Cambridgeshie Handicap and the Cesarewitch, two weeks later, are together known as the Autumn Double.