(Note: for understanding
the following review of the book “Il Terreno Oncologico. Semeiotica
Biofisica: Contributo Clinico alla Prevenzione Primaria del Tumore”
(in press), doctor needs accurate and complete knowledge of Biophysical
Semeotics. However, in the interest of reader, who is not jet
experienced in the new method, to facilitate him in the comprehension of
paper, I provide some useful informations [in square parenthesis], in a very easy manner from the technical point of view).

Before illustrating Clinical
Microangiology of malignant tumours, both liquid and solid, it is
necessary to describe in details the oncological terrain or pre-oncological
stage, where is constantly present the Congenital Acidosic
Enzyme-Metabolic Histangiopathy (CAEMH), conditio sine qua non of
the oncological terrain, and, therefore, of malignancy, elsewhere
exhaustively illustrated (See: later on and Bibliography in Home-Page).

CAEMH-a, a congenital, functional, mythocondrial cytopathology, inherited almost
from the mother, lasts alllife
long, although variable in intensity, in relation to life-style, diet
and employment ofboth
bioactive products and histangioprotective drugs.

On the contrary,
oncological terrain, originated on the basis ofCAEMH-a, can disappears, to be caused or, finally, increased by unfavourale
enviromental conditions, by improper diet, etymologically speaking,
which acts in a negative manner on the CAEMH-a as well as on the biological systems controllling oncogenesis. In other
words, oncological terrain, in which CAEMH-a plays a major role, can beinduced
and fortunately reversed, almost completely, with the aid of correct
diet, etymologically speaking, and by means of histangioprotective
treatment (See later on).

Biophysical
Semeiotics
allows doctor to recognize and evaluate “quatitatively”
the pre-oncological stage,i.e. oncological terrain,by the aid of a large number of methods, different in simplicity,
refinement, practical application and amount of information.. The
usefulness of all these clinical methods, in doctor’s daily work, is
pointed out by the fact that absence of oncological terrain rules out
the presence of malignancy, influencing remarkebly the diagnostic iter,
large scale screening, and therapeutic monitoring.

In fact, age, sex,
familiarity have now , i.e. from biophysical semeiotic point of
view, a very little value in oncological prevention, because
exclusively clinical recognition of oncological terrain requires
urgently that patient undergoes to instrumental and sophisticated
semeiotics, early, in a rational manner, after ascertaining the
microcirculatory activation type II, non-associated [= pathological
preconditioning] even in a small part of well defined biological system, where preconditioning
results pathological, besides to other numerous biophysical
semeiotic signs (See: Early Diagnosis of Heart .... in Home-Page).

In each human there are
about 1013 cells: not all of these cells, but almost all, can
grow and replicate to present as a clinical cancer in every time, due
mutations occuring during cellular reproduction. However, cancer is a rare
disease at the cellular level. As a matter of facts, up to 30% of all
individuals in the developed countries will present clinically with one
of a wide varietyof cancer
at some time of their life. Consequently,if the number of cell at risk is taken into account, given the relatively
small cases of malignancies, it is obvious that this disease only
rarely escapes normal protective systems. Therefore, tumours can
originate and grow exclusively when psycho-neuro-endocrine-immunological
system is profoundly modified. As regards both primary prevention and
clinical diagnosis of malignancy, in my opinion, essential isanswering to the following question:

“What
does carachterize oncological terrain from the clinical point of
view?”.

In
fact, in order to achieve efficacious prevention on large scale
it is unavoidable that all the modifications occurring in the biological
controll system could be easily and promptly ascertained and properly
evaluated with the aid of clinical method, i.e. by the use of a
sthetoscope, and certainly without application of sophysticated
semeiotics, that does not apply in all individuals, and, moreover, only
a few doctors can utilize them.

If it is possible answering affirmatively to this
question, a second one immediately follows:

“The
oncological terrain which certanly canbe induced, is also in some way reversible?”

It is urgent and
necessary to know ifthe
oncological terrain can be reversed, i.e. it can totally or
greatly disappeare, with the aid of drugs or diet, etymologically
speaking, which exert a favourable influence on modifications of the
psicho-neuro-endocrine-immunological system.

At first, we must both
face and resolve essential problems concerning oncological terrain,
discussing, once more,accurately
the pathological mitochondrial condition, which represents its
fundamental basis,when it
is particularly severe: CAEM-a. (See Congenital
Acidosic Enzymo-Metabolic Histangiopaty in Home-Page)

CAEM-a,
conditio sine qua non also of oncological terrain,
represents actually a severe alteration of mitochondrial oxidative
phosphorilation processes, i.e. ATP synthesis, as well as nucleophyl
substitution, variable in intensity from individual to individual, from
tissue to tissue and from part to part of the same tissue.

From
morphological point of view, it is well-known that CAEM-a
is characterized by prevalence of right cerebral hemisphere – right
cerebral dominance – or more correctly said, of right Planum
temporale, which is notoriously located between Heschl’s
convolution (gyrus) and posterior part of Silvio’s fissure.

One
can ascertain CAEM-a
as elsewhere described (See Bibliography in Home-Page). However, it is
advisable an easiest manner, briefly illustrated in following: in
healthy individual in supine position and psycho-physically relaxed,
doctor applies its left hand, at first, on right parietal-temporal
region of the subject and then on the left one, when the individual to
be examined presses forefinger-pulp and thumb-pulp together, obviously
at first, of the left hand and, subsequently, of the right one; at the
same time doctor evaluate somatosensorial evoked potentials (SEPs)
[=
in pratice, latency time of the cerebral-gastric aspecific reflex, as
indicated in Fig. 1].

In
case of CAEM-a,
latencytime (lt) of the
reflex is 6 sec.when
trigger-points of right hemisphere are stimulated, whereas lt results 7
sec. if left cerebral trigger-points are activated; in later situation,
intensity of gastric aspecific reflex appears clearly lower: 2 cm versus
1 cm. respectively.Of
course, the degrees of reflex intensity are reversed in presence of
dominance of left cerebral hemisphere.

At
this point, in order to observe the interesting evolution from CAEM-a
to oncological terrain, one must remember, once a time, an
usefull biophysical semeiotic syndrome, really helpful to general
pracitioner in everiday activity : the Rethyculo-EndothelialSystem Hyperfunction Syndrome(RESHS), that is subdivided in“complete”, “intermediate” and “uncomplete” type.

As
far as clinical significance is concerned, CAEM-a
corresponds to ESR elevation and proteins electrophoresis alterations,
but surely is of both more sensitive, specific and, therefore,
reliable. In fact, in case of a slight attack of flu, e.g., ( or,
even, in advanced malignancy)it
often turns out that both laboratory tests are in normal ranges, while
RESHS “uncomplete”, carachteristic of this viral disease, is always
present since the first, asyntopmatic stage, when evaluated by aid of
the Restano’s maneouvre[=
patient clinches fists and does not breath, i.e. boxer’s and
simultaneously apnea test: sympathetic hypertonus]
(See: Glossary in Home-Page): in healthy young person, psycho-physically
relaxed, in supine position, digital pressure of “mean” intensity,
applied on mean line of breast-bone, iliac crests and spleen projection
area, provokes the gastric aspecific reflex after a latency time of 10
sec.: RESHSphysiological
(Fig.1).

In
case of bacterial infection, contagious diseases of infancy, viral
in origin, connective tissue disorders (Rheumatoid Arthritis, Lupus
Erithematosus, a.s.o.), malignant tumours, a.s.o., lt decreases to 6
sec. with a latency time of reinforcing [=
augmentation of reflex intensity]
of 8 ±
1
sec.: RESHS “complete”. On the contrary, in viral flu, as in commom
flu, digital pressure, applied on cutaneous projection area of spleendoes not brings about any gastric aspecific reflex, because white
germ centres of splenic (red) pulp are not activated in these conditions:
RESHS “uncomplete”. On the contrary, in Herpes Zoster as well as in
common infectious diseases of infancy, caused by viral, RESHS is
“complete”.

Finally,
in bacterial disorders, provoked by Gram-negative, i.e. in common acute
cystitis(E.coli) or
in antritis brought about by H. pylori, RESHS turns out to be
“intermediate”(Tab.1).

Fig.
1

Reticulo-Endothelial
System Hyperfunction Syndrome:in
the stomach, both fundus and body are clearly dilated, while
antral-pyloric regioncontracts
(= gastric aspecific reflex), when digital pressure of mean intensity is
applied on middle line of breast-bone, iliac crests and, only in the
“complete” type, also on cutaneous projection area of the spleen (See
text and Tab 1).

Interestingly,
RESHS allows doctor to monitoring in objective manner the course of
wathever disorder in objective manner. As a matter of facts, the degree
of both lt and lt of reflex reinforcing provides essential information
about the course of the underlying illness.

From
the practical view-point, it is of interest that exclusively during the
changing of RESHES, from “uncomplete” to “complete” type, doctor
has to prescribe immediatly, without delay, antibiotic drugs.

By
a long, well-established experience,I can state that doctor recognizes easily, with the aid ofBiophysical Semeiotics, individuals CAEMH-a-positive
atoncologicalrisk, quantifying it and, therefore, estimating the
probability of tumorur.

RESTANO’S
MANOEUVRE TYPE A AND TYPE B.

In
85 % of malignant tumours, both solid and liquid, in initial stage and
in 100 % when malignancy is already advanced, RESHS is of “complete”
type, showing a characteristic latency time (lt) of only 3 sec.
and latency time of reinforcing of 5,5 ±
0,5 sec..
On the contrary, in common viral diseases of infancy and in bacterial
disorders, connectivitis, a.s.o., lt is 6 sec. and latency time
of reinforcing is 8,5±0,5
sec.; p <0,001.

Interstingly,
in healthy without positive familiarity for tumours, Restano’s
manoeuvre brings about only a small modification of basal lt and lt
of reinforcing is9,5 ±
0,5 sec.

Finally,
it is of great interest thatin
both initial stage of tumours in 15 % of cases and patients at risk
of cancer, basal value oscillate in normal ranges, but it becomes
plainly pathological after Restano’s manoeuvre, obviously
with different degree (Tab. 3)

Restano’s
manoeuvre and RESHS

(in
parentheses basal values)

tl

tl
del rinforzo

85%
P. with initial andall
with advanced tumour

3
sec. (3 sec.)

5,5±0,5
sec. (5,5±0,5
sec.)

P.
successfully operatedof
tumours

3
sec. (10 sec.)

8,5±0,5
sec. (>10
sec.)

Healthies
without familiarity for tumours CAEMH-a-neg.

8,5 ±0,5
sec. (10 sec.)

9,5±0,5
sec. (>10
sec.)

P.CAEMH-a-positive
but at oncological risk and 15% P. with initial neoplasm

3
sec. (10 sec.)

7±1
sec. (>10
sec.)

Tab.
2

Restano’s
manoeuvre

type
A: lt 3 sec gastric aspecific reflex

I
=/-
1 cm.

tl
II =/-
9 sec.

tipo
B: tl 3 sec. gastric aspecific reflex

I
> 1 cm.

tl
II6-8 sec.

Tab.
3

At
this point doctor must remember the essential role, Restano’s
manoeuvre plays in movingfrom
CAEMH-a
syndrome to cancer growing. Restano’s manoeuvre represents,
indeed, the activation of Reticulo-Endothelial-System, at the present
time termed Monocyte-Macrophage System. As indicates Tab. 3, there are
two type of this manoeuvre: type A and type B.

In
order to observe and to evaluate “quantitatively” the manoeuvre,
subject to be examined is invited not to breath for 10 sec. (apnea
test), or alternatively doctor applies intense, occlusive digital
pressure on a brachial artery for the same time (10 sec.), i.e.
“variant” Restano’s manoeuvre, as well as to clinching
fists: sympathetic hypertonus. Before the individual keep again
to normally breath, doctor applies digital pressure onmiddle line of breast-bone (or on iliac crests or cutaneous
prjection area of the spleen) for evaluating RESHS [=
lt of gastric aspecific reflex,i.e. sundus and body of the stomach
appear dilated, while antral-pyloric region contracts,and lt of reflex reinforcing](Tab. 1).

As
described-above, Restano’s manoeuvre points out RESHS
activation. As a matter of facts, e.g. during infectious disorder, it
appears earlier type A, then type B and finally
RESHS, “complete”, “uncomplete” or “intermediate”, in
relation to the nature od underlying disese.

On
the other hand, when therapy ameliorates disorder and patient improves,
first of all RESHS disappears, and therafter also type B of the
manoeuvre is not ascertained, while appears type A , which lasts as far
as patientcompletelyrecovers.

The
presence of Restano’s manoeuvre type B, i.e. the activation of
Reticulo-Endothelial System, is due to the fact that marrow products
mononuclear cells, which migrate to the thymus and lymphoid tissues, as
well as myelopeptides, that stimulate antibodies synthesis, in order to
increase biological defense. Consequently, there is marrowmicrocirculatory activation type I, associated [=
“light” digital pressure on breast-bone, e.g.,provokes three ureteral reflexes, which permit doctor to evaluate
vasomotility and vasomotion of marrow microcirculation, by the intensity
of reflexes fluctuation].

On
the contrary, in individual with oncological terrain stimulation
of antibodies synthesis appears to be whether absent or not
statistically significant (lt of MALT-gastric aspecific reflex: 5-6
sec.). Moreover, in healthy, digital pressure on middle line of
breast-bone, after a lt of about 20 sec., increases the diameters of
BALT cutaneous projection area(­
3 cm.), whilein oncological
terrain they increase only £
1 cm. [=
auscultatory percussion of both posterior and anterior thoracic wall,
allows doctor to ascertained , along middle scapular and, respectively,
clavicular line, three round hypophonetic area – BALT -of a diameter oscillating in a chaotic-deterministic manner, 6
times/min, from 0,5 cm. to 1,5 cm., with a period varying
from 9 sec. to 12 sec.- mean value 10,5, a fractal
number,as do all
biological systems].

To
demonstrate both internal and external coherence of biophysical theory
it is whortwhile that simultaneously, during Restano’s manoeuvre,
all sites of antibodies synthesis (MALT) show biophysical semeiotic
features of active hyperemia, more precisely speaking, the
microcirculatory activation type I, associated (See earlier), of
course of different intensity in relation to causal agent, indicating
the acute phase of antibodies production.

Notably,
the following clinical evidence corroborates this interpretation: in
healthy, subcutaneous injection of desensitizing vaccine, according to
Besredka,induces first the
type A, later type B and finally RESHS.

While
in Restano’s manoeuvre type A is always contemporaneously
present Selye’s syndrome, variable in intensity, beside type B doctor
observe characteristic modifications of
psycho-neuro-endocrine-immunological system, as in malignancy, liquid or
solid, as well as in patients, who successfully underwentto surgery. I have termed this pathological situation of
biological systems for protecting against cancer as “oncological
terrain”.

As
regards the evaluation of neuro-stimulatotors, neuro-modulators,
hormonal neuro-modulators, free-oxygen-radicals, and preconditioning see
Bibliography in Home-Page.

ONCOLOGICAL
TERRAIN.

Biophysical
Semeiotics
allows doctor to both recognize and “quantitatively” assess at the
bed-side the biological terrain, on which cancer can originate and grow
(Tab.4 and 5).

Complete,
exhaustive biophysical semeiotic evaluation of
psycho-neuro-endocrine-immunological system as well as of products,
indicated in Tab.5,needs
obviously a years-long study and exprienceat the bed-side. Due to lack of space, I invite the reader, who
like to complete this topic, to see former articles in Bibliography, in
Home-Page.

However,
I describe a method, easy to performe, reliable in detecting the
presence of oncological terrain, as follows: in healthy, supine
and psycho-physically relaxed, during rythmic palpation of breast (similuated
sucking test, SST) the mammary gland-gastric aspecific reflex lasts 7
sec. exactly. On the contrary, in oncological terrain the
duration augments to 8-9 sec. (p < 0,01) due to prolactin
increasing.

In
fact, in such condition there is a loss of balance as far as regards
restraining and stimulating substances acting on prolactine secretion (hormons,
neuro-transmitters, a.s.o.) in favour of the later ones. Actually, SS
test, easy to perform in a few seconds, plays a primary role in
detecting complicated modifications in biological systems that defend
humans against cancers.

In
presence of oncological terrain, because of hormonal levels and
neurotransmettitors modifications, gastric aspecific reflex during to
SST,lasts for more than
12 sec., due to severe reduction of endogenous opiates as well as
somatostatine, whereas prolactin clearly increases. Consequently, Biophysical
Semeiotics permits doctor to corroborate at the bed-side the
relation between immunological process and psycho-neuro-endocrinological,
I illustrated clinically in earlier articles (See: Bibliography in
Home-Page).

There
are other, numerous methods, both rapid and easy to perform at the
bed-side, to estimate in reliable manner the presence and intensity of oncological
terrain, apart from the “direct” evaluation of GH-RH, ACTH-RH,
SST-RH and melatonin-secretionor
to “quantitative” assessment of endogenous opiates, resulting an easy
diagnosis, useful for large scale screening.

In
following, I describe briefly some very practical method for evaluating
oncological terrain:

1)First doctor evaluates the dimension of cutaneous projection area
of one BALT site, than he invites patientto close intensively both eyes, in order to avoid the light.
After 5 sec. or more, of course, in healthy individual,the same cutaneous areaclearly
increases, in direct relation to the intensity of melatonin secretion:
normallydiameter doubles
reaching the value of 6 cm. (NN = 3 cm.), whereas in oncological terrainaugments slightly:£
1 cm.

2)
Analogously, BALT-gastric aspecific-reflex physiologically shows a lt of
6 sec. (chronic antibodies synthesis), but lowers
to 3 sec. after closing both eyes (5 sec. therafter) wiht
an intensity
greater than that of basal one. On the contrary, in case of oncological
terrain lt as well as intensity of the reflex modifie in a small
manner, in inverse relation to the seriousness ofdisorder.

3)
In healthy subject, apnea test, lastingfor about 10 sec., reduces of 1/3 diameter o cutaneous projection
area of a BALT site, whereas in patient involved by oncological
terrain the lowering reaches only 2/3 or less.

SIMULATED
SUCKING TEST AND ONCOLOGICAL TERRAIN.

The
assessment of oncological terrain by means ofboth Simulated Sucking Test (SST) and simultaneous breast
preconditioningoffers to
doctors interesting information: one evaluates basal duration of SST ,
i.e. during rhytmic palpation of a mammalian gland doctor
estimates duration of breast-gastric aspecific reflex, (NN == 7 sec.
exactly). After precisely 5 sec., doctor performes again the manoeuvre
for a second ( or a third, as he likes it) time.

In
healthy subject,the durationdecreases
by degrees to 6 sec and 5 sec, respectively, since dopaminergic toneof diencephalohypophysial axis physiologically increases. On the
contrary, in oncological terrain the duration rises, first to 8 sec. and
finally to³
12 sec.

Notoriously,
in both this condition and malignant tumours the dopaminergic tone of
diencephalohypophysial axis appears reduced and consequently prolactin
secretion augments. Therefore, the diagnostic valueof SST and preconditioning is of paramount importance in both
ascertaining oncological terrain and diagnosing malignancy.

As
a matter of facts, in malignant cancers, solid as well asliquid, basal SST persists for ³10
sec.; identical value is observed in initial stages of cancer, in
patients who successfully underwentsurgeryand,
finally, in individual at real risk of tumour, i.e.with oncological
terrain.

Before
65 years oldSST is neither age- norsex-dipendent (NN = 7 sed. exactly). After apnea test lasting
about 10 sec. (= patient does not take any breath)SST increases from 12 to 20 sec. pathologically (NN = 10 sec.
precisely) in onological terrain, so that basalSSTof 12 sec. in
individual under 65 years of age indicates by selfa pathological condition of activated immunological system.It is of interest that the from CAEMH (=Congenital Acidosic
Enzymo-Metabolic Histangiopathy) to Restano’s manoeuvre typ A and,
then, type B, of variable intensity, indicating the presence of
oncological terrain, the passage is both slow and gradual.

A
long, well established experience allows me to state that normocaloric,
correct diet and physiologicallife-style, as indicated inthe decalogue oa European Society for Study and preventio of
Cancer and, finally, the use of histangioprotective drugs (Co Q10,
Carnetine, Vit A and E, Bioflavonoidds, Capsaicin, a.s.o.)causes disappearing oncological terrain.

From
the practical point of view it is unncessary to search for malignancy
when a patient is not ivolved by oncological terrain, i.e. when
biophysical semeiotic signs, characteristic of this alteration, e.g.
Restano’s manoeuvre type B, are absent. Interestingly, this knowledge
is useful for patient, doctor and NHS. On the contrary, in presence of
modifications of psycho-neuro-endocrine-immunonogical system, docto must
exclude the tumour, even in early stage. Soon thereafter, both
efficacious therapy and correct diet, ethimologically speaking, in order to bring about the
normalisation of all alteredparameters, relating to SST, GH, IGfs, endogenous opiates,
free Radicals, antioxidants, Co Q10,
hyperinsulinemia-insulinresistanceand melatonin.

For
the first time doctor can evaluate clinically by means of Biophysical
Semeiotics the epiphysial secretion of melatonib,
N-acetyl-5-methoxy-triptamin, which notoriously stimulates the
antibodies synthesis activating opiates receptors, i.e. indirectly, as
well as inhibits both normal and neoplatic cells growing.

1)
in healthy, whose eyes are closed since 5 sec. or mor, antibodies
synthesis appears clearly enhanced: for instance,BALT cutaneous projection area shows its diameters doubled and
simultaneously peristaltic waves velocity, e.g. in the stomach, results
clearly slower, because it needs ³
12 sec. for reachingantral-pyloric
region, starting from initial part of the fundus [=
ascertained cutaneous projection of the great gastric curvature, doctor
gives a pinch to the skin covering breast-bone ensiform appendix:
immediately a peristaltic wave originates, which physiologically reaches
antral –pyloric region in 5 sec. exactly]
. These modifications last for 30 sec. precisely, i.e. their duration
results identical to that of melatonin secretion under the same
condition (eyes closed) (See later on);

2)mean-intense digital pressure, applied on epiphysial cutaneous
projection area, i.e. 2 cm above and 2 cm posteriorly external acoustic
meatus (Fig. 2), after about 5 sec. provokes both the same biophysical
semeiotic signs, above described at point 1), which show identical
duration, proving clearly internal as well as external coherence of the
theory;

In
oncological terrain melatonin secretion results evidently altered of
variable degree from individual to individual, of course, easy to
ascertain by the aid of above-illustrated parameters.

Interestingly,
a clinical evidence suggests that epiphysial activityis evaluated in a rapid and reliable manner by means of Biophysical
Semeiotics: physiologically stimulating endogenous opiates secretion,
with the aid of intense digital pressure on mandibular nerve, the
peristaltic wave in the stomach slows down so far that it needs³
12 sec. (NN = 5 sec precisely) for reaching antral-pyloric region. At
the same time, intensity of cerebral-gastric aspecific reflex during the
evaluation of cerebral evoked potentials [=
patient, in supine position and relaxed, push two finger-pulps against
each other while doctor estimates lt of cerebral gastric aspecific
reflex on right and then, on links hemisphere: in health, lt is 6 sec.
and 7 sec. respectively with intensity of 2,5 cm.]
decreases from normal value of 2,5 cm. to < 2 cm. If these parameters,
however, are evaluated both after the healthy individual closes eyes and
the application of intense digital pressure on epiphysial cutaneous
projection area for 30 sec. (Fig.2), doctor observes clear modifications
of parameters value: lt ³
10 sec. and < 1,5 cm respectively.

This
experimental evidence suggests that melatonin, secreted under this
condition, acts directly as well as indirectly by means of endogenous
opiates, of which action, therefore, results more efficacious, allowing
thus a “quantitative” assessmentof actual level of N-acethyl-5-methoxy-tryptamin.

In
conclusion, in order to ascertain in daily practice oncological terrain,
in complete, qualitative as well as quantitative manner, it appears
advisable diagnostic iter, easy and reliable, described as
follows:

Staring
from 20-25 sec of GH-RH stimulation, evaluated above mentioned
parameters, stopped the manoeuvre, immediately doctor estimates SST
duration, whis physiologically is < 10ssec., due to the fact that valid secretion of somatostatin as
well as physiological level of dopamine in diencephalohypophysial axis
restrain the prolactin secretion, induced by GH. In fact, both
substances influence negatively prolactin secretion.

At
theend of the stimulation
of GH-RH secretion ( and of all other RHs secretions, of
course) in healthy individual pancreas augments itsdiameters (practically, pancreatic inferior border lowers due to
congestion for exactly 8 sec. Interstingly, this value is
fundamental in diagnosing alterations of glucose metabolism. In
fact, in case of diabetes mellitus the lowering duration of
inferior pancreatic margin amounts to < 8 sec., in direct
relation to severity of the syndrome. On the contrary, in both IGT and hyperinsulinemia-insulinresistance the pancreatic
enlargement lasts for > 8 sec. , once again in correlation
with the increasing of hormonal secretion, showingthe possibility of evaluating simultaneously different disorders
by means of Biophysical Semeiotics , since the numerous
biological systems are connetted very closely from both structural and
functional point of view.

At
this point, oncological terrain is recognized and can be
“quantitatively” evaluatedin other manners, as follows:

As
far as the evaluation of endogenous opiates system concerns, that can be
activated also by melatonin and myelopeptides, a refined method is
represented by assessment of cerebral-gastric aspecific reflex intensity,
first, at basal line (NN ³
2 < 3 cm.)and, then,
after intense digital pressureon mandibular nerve for 25 sec. , during Cerebral Evoked
Potentials (See earlier): in healthy, intensity of cerebral gastric
aspecific reflex is reduced to a half., due to the restrainingaction of endogeous opiates as regards the neurotransmission.

In
oncological terrain, typical lack ofb-endorphins
as well as met-enkephalin provokes a very small decreasing of
cerebral-gastric aspecific reflex under described condition.