Abstract

It is difficult to directly co‐register the 3D FMT (Fluorescence Molecular Tomography)
image of a small tumor in a mouse whose maximal diameter is only a few mm with a larger CT
image of the entire animal that spans about ten cm. This paper proposes a new method to register 2D flat and 3D CT
image first to facilitate the registration between small 3D FMT images and large CT
images. A novel algorithm based on SMC (Sequential Monte Carlo) incorporated with least square operation for the registration between the 2D flat and 3D CT
images is introduced and validated with simulated images and real images of mice. The visualization of the preliminary alignment of the 3D FMT and CT
image through 2D registration shows promising results.