Characterization of rabies virus from a human case in Nepal

Characterization of rabies virus from a human case in Nepal
Pant, G.; Horton, D.; Dahal, M.; Rai, J.; Ide, S.; Leech, S.; Marston, D.; McElhinney, L.; Fooks, A.
2011-04-01 00:00:00
Rabies is endemic throughout most of Asia, with the majority of human cases transmitted by domestic dogs ( Canis familiaris ). Here, we report a case of rabies in a 12-year-old girl in the Lalitpur district of Nepal that might have been prevented by better public awareness and timely post-exposure prophylaxis. Molecular characterization of the virus showed 100% identity over a partial nucleoprotein gene sequence to previous isolates from Nepal belonging to the ‘arctic-like’ lineage of rabies virus. Sequence analysis of both partial nucleoprotein and glycoprotein genes showed differences in consensus sequence after passage in vitro but not after passage in vivo .
http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.pngArchives of VirologySpringer Journalshttp://www.deepdyve.com/lp/springer-journals/characterization-of-rabies-virus-from-a-human-case-in-nepal-0byxbD4cRG

Abstract

Rabies is endemic throughout most of Asia, with the majority of human cases transmitted by domestic dogs ( Canis familiaris ). Here, we report a case of rabies in a 12-year-old girl in the Lalitpur district of Nepal that might have been prevented by better public awareness and timely post-exposure prophylaxis. Molecular characterization of the virus showed 100% identity over a partial nucleoprotein gene sequence to previous isolates from Nepal belonging to the ‘arctic-like’ lineage of rabies virus. Sequence analysis of both partial nucleoprotein and glycoprotein genes showed differences in consensus sequence after passage in vitro but not after passage in vivo .

Journal

Archives of Virology
– Springer Journals

Published: Apr 1, 2011

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