In the industrial age, many people are faced with stress. Religion and spirituality can be effective in reducing stress. The aim of this study was to do relationship between religious attitudes and spiritual intelligence and anxious among medical students.The research method was structural equation model. The purpose of this study is applied design. The population was 1,232 medical students. 290 students were selected by multistep random sampling method. The research instruments were Khodayari's religious attitudes questionnaire, Abdollahzadeh et al.'s spiritual intelligence questionnaire and Speilberger's state/trait anxiety questionnaire. There is negative relationship between religious attitudes and anxiety. There is negative relationship between spiritual intelligence (understanding and communication with the source of life) with anxiety. Regression analysis showed that understanding and communication with the source of life, worship, behavior and human life, social issues and worldviews and beliefs predict students' anxiety. The results of path analysis showed that understanding and communication with the source of existence, worship, worldviews, ideologies and social issues of human life through changing behavior and effect on students' anxiety indirectly but human life and behavior has directly effect on students' anxiety. On the other hand, understand and communicate with the source of life and social issues through the sacrifice of human life and behavior can have indirect effect but worship can have direct effect on human life and behavior. The findings of this study emphasized on the use of religious attitude and spiritual intelligence in students' anxiety.