The Effect of HIV and Aging on Functional Connectivity, Connectome Similarity, and Structural changes

1Electrical and Computer Engineering, University of Rochester, Rochester, NY, United States, 2Dept of Biostatistics and Computational Biology, University of Rochester, Rochester, NY, United States, 3Department of Imaging Sciences, University of Rochester, Rochester, NY, United States, 4Department of Neurology, University of Rochester, Rochester, NY, United States

We investigated the effect of HIV-infection and aging using resting-state
fMRI and T1-weighted structural images. First, we assessed the inter-network
functional connectivity and identified 8 resting-state networks associate with normal
aging. Second, we constructed a functional connectome similarity as a
global measure of neural connectivity pattern to assess the effect of age and
HIV infection. Lastly, we measured cortical thickness and brain volumetrics. We
found a significant effect of aging but not a definite additive or synergistic
effect of HIV infection in all three analyses.

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