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When they woge, a Lausenschlange's whole body gains yellowish grey scales and a slight boa-like pattern on them. They also gain sharp fangs, a forked tongue, and slit pupils, and they lose all their hair.

They are naturally stronger than humans and able to casually overpower humans and Mauzhertz. They are very stealthy, allowing them to sneak up on their victims.

One of the ingredients for the Heart purification potion is Lausenschlange Oil. It is unknown if Lausenschlange Oil literally comes from Lausenschlange or if it is just named after them.

Grimms use a bladed weapon known as a Lausenschlange Halberd to fight and kill them. The head is forged from pure gold and has multiple blades; the large blade is used for decapitation, and the pointed blade is used to slice open the abdomen.

Though they have fangs, they fight more like boa constrictors, strangling their prey with the very strong grip of their arms. They consider Mauzhertz their natural prey and will casually kill and eat them. Lausenschlange are known to be naturally aggressive, but they are perfectly capable of living with humans and having normal lives.

Crawford Grimm, one of Nick's ancestors, decapitated one, and after cutting open the Lausenschlange, he found the remains of a brother and sister in its stomach (presumably swallowed whole), showing they will also eat humans. Interestingly, while Crawford Grimm described them as cowardly and not that dangerous, Monroe contradicted this, stating it was surprising Nick was able to see one and actually live to tell the tale. Like many types of real snakes who are most dangerous when cornered, the same may be the case with Lausenschlange. Further evidence to support this is that the Lausenschlange Nick's ancestor killed only attacked when the latter had worked the former into a corner with no way to escape.

Despite their hostile relationship with Mauzhertz, Quinn, who was a member of the Resistance, worked closely with a Mauzhertz forger named Reginald to help wanted Wesen escape on the underground railroad, and he did not succumb to the instinct of eating Mauzhertz. This suggests that Quinn was a Wieder Lausenschlange.

Like many Wesen, Lausenschlange fear Hundjäger due to their ruthlessness and sheer cruelty.

The Lausenschlange grips his victims like a boa constrictor and typically preys on lesser creatures, such as Mauzhertz.

After two days of waiting in Vienna, I confronted the Lausenschlange in a dark alley. As I approached, he attacked, though had he recognized me for who I am, he would have not been so bold.

His carelessness cost him his head, which I severed neatly with one blow. No one witnessed our brief duel in the alley. I dragged his body, now in human form, back to my quarters where I could research his form for anatomical disfigurements.

With death, the Lausenschlange returned to its human form, the skin no longer tough and scaled. I sliced open his belly, exposing the horrid contents-the missing children.

The Lausenschlange had eaten them a day or two before.

I am glad I brought and end to this disgusting coward; I only wish I would have found him sooner.