Chemokines, signaling molecules that attract immune cells to infected cells, help protect the fetus from infection and prevent an attack on the placenta and fetus by the mother's immune system. But high levels of chemokines can also increase the risk of miscarriage. Now, scientists from Italy, the United States, and Croatia report that a molecule called D6 that targets certain chemokines reduced spontaneous abortion in mice, suggesting a new therapeutic strategy for protecting against miscarriage in humans (de la Torre YM. Proc Natl Acad Sci U S A. doi:10.1073/pnas.060751404 [published online January 29, 2007]).