Purpose: Recently, high-rise buildings are popular in korea due to high rate of land usage and cost performance in urban area. However, high-rise building causes several problems such as safety issues, cooling/heating load, stack effect, disaster prevention etc. The stack effect is one of the representative problems. Even though there are many researches on stack effect, there are few studies on design guideline considering local condition. Method: This study focuses on the change of pressure distribution according to the design factors which affects the airflow in high-rise residential buildings by simulation analysis. In this study, city, building floor, stairwell door leakage area, elevator door leakage area and changes of layout were considered ad the design factor. Result: The simulation results indicate that building height and ambient air temperature are significant design factor for stack effect.