SSM Health DePaul Hospital is a 476-bed hospital offering comprehensive medical services, including inpatient and outpatient surgeries using state-of-the-art technology and facilities. Opened in 1828, DePaul Hospital - St. Louis was the first hospital west of the Mississippi River and remains the oldest continuously existing business in St. Louis. DePaul Hospital serves patients from across the St. Louis metropolitan area, including the communities of Bridgeton, Florissant, Hazelwood, St. Ann, St. John, Maryland Heights and Overland.