WASHINGTON — Just a few blocks down Pennsylvania Avenue from the White House sits the Trump International Hotel, one of the newest luxury additions to President-elect Donald J. Trump’s real estate empire, and perhaps the most visible symbol of the ethical quandary he now confronts.

The Trump International operates out of the Old Post Office Building, which the federal government owns. That means Mr. Trump will be appointing the head of the General Services Administration, which manages the property, while his children will be running a hotel that has tens of millions of dollars in ties with the agency.

He also will oversee the National Labor Relations Board while it decides union disputes involving any of his hotels. A week before the election, the board ruled against Mr. Trump’s hotel in a case in Las Vegas.

The layers of potential conflicts he faces are in many ways as complex as his far-flung business empire, adding a heightened degree of difficulty for Mr. Trump — one of the wealthiest men to ever occupy the White House — in separating his official duties from his private business affairs.

Further complicating matters are Mr. Trump’s decision to name his children to his transition team, and what is likely to be their informal advisory role in his administration. His daughter Ivanka Trump joined an official transition meeting on Thursday, the day before Gov. Chris Christie of New Jersey was removed from his post leading the effort.

Mr. Trump’s hotel in Washington is in the Old Post Office Building, which is owned by the federal government. Al Drago/The New York Times

But ethics lawyers — both Republicans and Democrats — say it is far from blind because he would have knowledge of the assets in the trust and be in contact with the people running it, making it unlike a conventional blind trust controlled entirely by an independent party.

“To say that his children running his businesses is the equivalent of a blind trust — there is simply no credibility in that claim,” said Matthew T. Sanderson, a Washington lawyer and Republican who has worked on the presidential campaigns of John McCain, Rand Paul and Rick Perry. “Yes, the American public elected him knowing he has these assets, but unless he deals with this properly there will just be a steady trickle of these conflict-of-interest stories, and it could be a drag on his presidency.”

Mr. Trump, as part of his bid for the White House, released information about his financial holdings, which include more than a dozen hotels and golf courses; commercial real estate space, including Trump Tower and 40 Wall Street in New York; and marketing deals in the United States and abroad. But it is unclear how much information was not disclosed, in part because he declined to release even a summary of his tax returns — becoming the first presidential candidate not to do so in 40 years.

Rudolph W. Giuliani, a close adviser to Mr. Trump, said on CNN’s “State of the Union” on Sunday that excluding Mr. Trump’s family from a role in his businesses “would basically put his children out of work.” The public, Mr. Giuliani said, needs to trust Mr. Trump.

What Donald J. Trump Owns and Owes

The Republican presidential nominee has an interest in more than 30 U.S. properties, roughly half of which have debt on them.

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“You have to have some confidence in the integrity of the president,” Mr. Giuliani said. “The man is an enormously wealthy man. I don’t think there’s any real fear or suspicion that he’s seeking to enrich himself by being president. If he wanted to enrich himself, he wouldn’t have run for president.”

Hope Hicks, a spokeswoman for the transition, declined to respond to questions about possible conflicts of interest Mr. Trump might face as president. “The Trump Organization will respond accordingly,” she said.

A spokeswoman for Mr. Trump’s company said in a statement that the Trump Organization was already working to address possible conflicts.

“We are in the process of vetting various structures with the goal of the immediate transfer of management of the Trump Organization and its portfolio of businesses to Donald Jr., Ivanka and Eric Trump along with a team of highly skilled executives,” the statement said. “This is a top priority at the organization, and the structure that is ultimately selected will comply with all applicable rules and regulations.”

Experts said that even if Mr. Trump was exempt from some federal ethics rules, the public will expect him to not use his office to benefit his personal finances.

“He has campaigned on a platform of getting rid of corruption and that Washington is broken and we need new, refreshing change,” said Karen Hobert Flynn, president of Common Cause, a nonprofit that pushes for accountability in government. “As president, the American public expects that Mr. Trump will be held to a higher standard.”

In a statement on Monday, the General Services Administration said that the agency realized it must examine its Old Post Office lease with Mr. Trump’s family-owned business “to allow a path to be put in place to identify and address any potential conflict of interest.”

Also on Monday, Representative Elijah E. Cummings, Democrat of Maryland and the ranking member of the Committee on Oversight and Government Reform, called for an inquiry into how Mr. Trump will handle these potential conflicts.

“The American people have the right to know — they ought to know — exactly whether decisions are possibly being made that would benefit him, his family and his associates directly,” Mr. Cummings said in an interview.

The labor dispute in Nevada represents another potential complication. The president appoints all five members of the National Labor Relations Board. But over the past year, the Trump International Hotel Las Vegas has been in a battle with the culinary workers union, at first challenging an effort by hotel employees to unionize. The labor board ruled against him in July. Then the hotel, which Mr. Trump co-owns, refused to begin negotiations with the new union, and the labor board again ruled against it, in November. Other labor disputes with employees are pending.

“Will he as president of the United States of America use the power he has to interfere — given that he has a financial interest in the outcome of these matters?” said Bethany Khan, a spokeswoman for the 57,000-member Culinary Workers Union Local 226 of Nevada.

Perhaps most troubling for Mr. Trump, several ethics lawyers said, is a relatively obscure provision of the Constitution, called the Emoluments Clause, which prohibits any government official from taking payments or gifts from a foreign government, or even from sharing in profits in a company that has financial ties to a foreign government.

Mr. Trump’s hotel in Las Vegas, which has had cases before the National Labor Relations Board. Todd Heisler/The New York Times

Mr. Trump has had business deals with foreign governments or individuals with apparent ties to foreign governments, including multimillion-dollar real estate arrangements in Azerbaijan and Uruguay. His children have frequently traveled abroad to promote the Trump brand, making trips to Canada, the United Arab Emirates and Scotland. Closer to home, the Bank of China is a tenant in Trump Tower and is a lender for another building in Midtown Manhattan where Mr. Trump has a significant partnership interest.

“Doing business with a foreign corporation, be it in Azerbaijan, Turkey or Russia, if is it owned in part or controlled by a foreign government — any benefit that would accrue to Mr. Trump could well be a violation of the Emoluments Clause of the United States Constitution,” said Kenneth A. Gross, a political ethics and compliance lawyer in Washington.

There are also more general issues that could prove troubling. For instance, Mr. Trump will nominate the Treasury secretary, yet he owes hundreds of millions of dollars to banks, and he benefits from low interest rates set by the Federal Reserve, an institution he has criticized as political. The head of the Internal Revenue Service is also appointed by the president, and the agency is currently auditing Mr. Trump’s taxes and sets tax policy that directly affects his businesses.

But it is Mr. Trump’s real estate and financial holdings that represent the most sensitive ethical areas, the ethics lawyer said.

Mr. Trump’s children are already deeply involved in the daily operations of the Trump Organization. Ivanka is executive vice president for development and acquisitions, and is in charge of domestic and global expansion of the company’s real estate interests. Ms. Trump also has her own clothing, jewelry and footwear lines.

Even this week, Ms. Trump turned her appearance on Sunday on “60 Minutes” — with her father — into a marketing opportunity for her line of jewelry, with one of her employees urging reporters to write about the $10,800 gold bangle bracelet she wore during the interview.

Donald Jr. is also an executive vice president in the Trump Organization, and the company’s website says he directs new project acquisition and development in regions “from Eastern Europe to Southeast Asia, the Middle East to South America, mainland China to the United States.”

Eric is in charge of the Trump Organization’s golf course collection.

“We’ll be in New York and we’ll take care of the business,” Eric Trump said in an interview with “60 Minutes” that was broadcast on Sunday. “I think we’re going to have a lot of fun doing it. And we’re going to make him very proud.”