This paper elaborates on the Triple Helix model for measuring the emergence of a knowledge base of socio-economic systems. The ‘knowledge infrastructure’ is measured using multiple indicators: webometric, scientometric, and technometric. The paper employs this triangulation strategy to examine the current state of the innovation systems of South Korea and the Netherlands. These indicators are thereafter used for the evaluation of the systemness in configurations of university-industry-government relations. South Korea is becoming somewhat stronger than the Netherlands in terms of scientific and technological outputs and in terms of the knowledge-based dynamics; South Korea’s portfolio is more traditional than that of the Netherlands. For example, research and patenting in the biomedical sector is underdeveloped. In terms of the Internet-economy, the Netherlands seem oriented towards global trends more than South Korea; this may be due to the high component of services in the Dutch economy.