3 and Christmas flights the week of Nov. 7. Youll save 14 percent on average and more than 50 percent for some destinations, Hipmunk found. Thats based on an analysis of the median booking prices of the 20 most popular U.S. destinations for Thanksgiving and Christmas, which are: Orlando, Florida New York City (John F. Kennedy International Airport) Chicago New York City (LaGuardia Airport) Detroit Fort Lauderdale Atlanta For less-traveled destinations, however, prices fluctuate more, making it harder to identify a single best week to book holiday flights. Hipmunk found that this week