News tagged with discs

Research by New York University Biology Professor Michael Rampino concludes that Earth's infrequent but predictable path around and through our Galaxy's disc may have a direct and significant effect on geological ...

How does the hitchhiking, flat-headed remora fish attach to surfaces so securely yet release so easily? Suction was thought to be the easy answer, but Brooke Flammang, a biologist at the New Jersey Institute ...

Who knew Blu-ray discs were so useful? Already one of the best ways to store high-definition movies and television shows because of their high-density data storage, Blu-ray discs also improve the performance ...

Sony and Panasonic today announced that they have formulated "Archival Disc", a new standard for professional-use, next-generation optical discs, with the objective of expanding the market for long-term digital ...

A breakthrough using data from the Gaia-ESO project has provided evidence backing up theoretically predicted divisions in the chemical composition of the stars that make up the Milky Way's disc – the vast ...

The placid appearance of the Sun's surface belies a hot fireball of plasma in constant turmoil. A granular network invisible to the naked eye pervades the solar disc, with cells of hotter and colder plasma ...

As cars become more like PCs on wheels, what's to stop a hacker from taking over yours? In recent demonstrations, hackers have shown they can slam a car's brakes at freeway speeds, jerk the steering wheel ...

(Phys.org) —Cloud spotting seems to be growing in popularity as a hobby here on Earth. Now scientists studying the solar atmosphere are building their own collection of fascinating moving features that ...

(Phys.org) —ESA's XMM-Newton space telescope has helped to identify a star and a black hole that orbit each other at the dizzying rate of once every 2.4 hours, smashing the previous record by nearly an ...

DLG4

PSD-95 (postsynaptic density protein 95) also known as SAP-90 (synapse-associated protein 90) is a protein that in humans is encoded by the DLG4 (disks large homolog 4) gene.

PSD-95 is a member of the membrane-associated guanylate kinase (MAGUK) family. With PSD-93 it is recruited into the same NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins.

PSD-95 is the best studied member of the MAGUK-family of PDZ domain-containing proteins. Like all MAGUK-family proteins, its basic structure includes three PDZ domains, an SH3 domain, and a guanylate kinase-like domain (GK) connected by disordered linker regions. It is almost exclusively located in the post synaptic density of neurons, and is involved in anchoring synaptic proteins. Its direct and indirect binding partners include neuroligin, NMDA receptors, AMPA receptors, and potassium channels.