Later that day, Jared and Jensen took part in the Supernatural panel with their co-star Misha Collins, Mark Sheppard, and others.

At the end of the panel, guests held up candles in support of Jared‘s Always Keep Fighting campaign. Jared has opened up in the past about his own battles with depression.

“I’m so humbled,” Jared said when the moment happened. “With the Always Keep Fighting campaign, it feels a lot like it’s grown into something bigger than I ever could have imagined. And it’s the same with the show, and this character and guys I’ve been working with for 11 years now. It’s so cool and so, so humbling. I feel like I’m the old guy here! I’ve been here for 11 years doing Comic-Con but it’s such a cool experience. I mean, this is what I dreamed of as a kid. I am so, so humbled.”

FYI: Paul is wearing a John Varvatos shirt.

25+ pictures inside of Jared Padalecki and Jensen Ackles at the panel… More Here! »

Jared recently opened up about his battles with depression while showing some love and support for nonprofit organization To Write Love on Her Arms (TWLOHA), which helps those struggling with depression, addiction, self-injury and suicide.

“And I, in the past, have had my own struggles of not [being] so happy with where I am in life, which is strange and I think it goes to show… Maybe a lot of people don’t know this, but Season 3, we were shooting an episode and I went back to my trailer to get changed and just kind of broke down,” Jared shared to Variety.

He added, “A doctor came to set and talked to me for about 30 minutes, or 45 minutes and said, ‘Jared, I think you’re clinically depressed. I think I should write you a note and we can shut down production for five days and then we can take it from there.’ And it kind of hit me like a sack of bricks.”

“Earlier someone asked me if season 10 was it and my only answer was, ‘I hope not. But if it is, it’s something to be proud of, and if it’s not, we’ll carry on,’” Jaredrecently toldJustJaredJr.com. “I feel like season eight and nine, specifically, we caught a second wind. We had new storylines and new characters who brought such life to it. As a fan of the show, I’ve been excited an uptick in the quality of the show. They’re creating new and fun things, and if they keep doing that, we’ll see.”

Jared Padalecki and Jensen Ackles make their entrances at The CW Network’s 2014 Upfront Presentation held at The London Hotel on Thursday morning (May 15) in New York City.

The guys were joined on the carpet by their co-star Misha Collins, who was just upped to series regular status for next season!

“Something happens in the finale that is a first we’ll see,” Jared told JJ on the carpet. “I’d say don’t miss the last 30 seconds of the finale.”

Misha told us, “I can say that the fans are going to freak out. I think it’s very chilling and disturbing. When I read the script for the finale, I was definitely shocked. I thought, ‘Can they do this?’ The last five seconds!”

“I’m going to one up [Jared and Misha] and say its the last second,” Jensen said. “The moment the screen goes to black. The last second. There are multiple characters involved. There’s a predicament now.”

We can’t wait to watch! Tune in to the Supernatural season finale on Tuesday, May 20 @ 9PM on The CW!