Spring 2000 Immunology Exam #3 - Chapters 8 -
10

There is no time limit on this test, though I have tried to
design one that you should be able to complete within 3 hours,
except for typing. You are not allowed to use your notes, or any
books, any electronic sources, nor are you allowed to discuss
the test with anyone until all exams are turned in at 9:30 am
on Monday April 10, 2000. EXAMS ARE DUE AT CLASS TIME ON MONDAY
APRIL 10. You may use a calculator and/or ruler. The answers
to the questions must be typedon a separate sheet of paper
unless the question specifically says to write the answer in the
space provided. If you do not write your answers on the appropriate
pages, I may not find them unless you have indicated where the
answers are.

-3 pts if you do not follow this direction.
Please do not write or type your name on any page other than this
cover page. Staple all your pages (INCLUDING THE TEST PAGES)
together when finished with the exam.
Name (please print here):

Write out the full pledge and sign:

How long did this exam take you to complete (excluding typing)?

I. Define these terms - 2 pts each. When the term is
followed by an asterisk (*), provide a specific example to further
demonstrate your knowledge. These terms can be define succinctly
so using a lot of words is not the best way to demonstrate your
fluency with these terms. However, do not leave out important
information that you assume the reader knows. Be sure to avoid
the word "it".

Questions that require you to synthesize what you know:
8 pts.1) Explain the selective advantages and selective disadvantages
behind the concept of original antigenic sin.

9 pts.2) Design a potential vaccine to protect us from leprosy.
Remember that leprosy lives inside macrophages. There will be
more than one right answer to this question but you must provide
an answer that is consistent with what we have learned so far.
A complete answer will include what is to given to the patient
and why this would work as a vaccine.

9 pts.3) Design a potential vaccine against HIV that will work for
a lifetime. Remember that HIV infects CD4+ cells and HIV envelop
proteins mutate 65 times faster than the flu virus. There will
be more than one right answer to this question but you must provide
an answer that is consistent with what we have learned so far.
A complete answer will include what is to given to the patient
and why this would work as a vaccine.

8 pts.4) Since IgE gives us mostly allergic responses, why did we
evolve it in the first place? In your answer, provide at least
three specific effects that contribute to IgE responses being
advantageous.

8 pts.5) Explain how it is possible that so many APC's can wind
up congregating in a single infected tissue.

8 pts.6) We all know plasma cells cannot isotype switch. Think about
this: armed TH cells express CD40L after encountering B cells
displaying antigen, and IL-4 induces isotype switching. The book
is not clear on this fact but you should be able to deduce the
answer. Where is the most likely location for isotype switching
to occur? To receive full credit, you must explain your answer.

The last two questions are very large ones that integrates
many concepts and processes.
15 pts.7) Using an outline format, list how your immune system is
activated after you have just spent the day with a runny-nose
child who has given you a virus that you now must fight off. Begin
after the virus has infected your cells and don't stop until all
the viruses are gone. This answer should include all the major
parts of a complete immune response. You do NOT need to list steps
involved in signal transduction pathways.

15 pts.8) Use an outline format to list the major steps involved
in an adaptive immune response that begins with a splinter in
your thumb and winds up with an IgG antibody response to eventually
eliminate the bacteria that were resting on the splinter. Make
sure you include what happens after the antibodies are made that
leads to death of the cells. You do NOT need to list steps involved
in signal transduction pathways.