The conversation was during filming for "Oprah's Super Soul Conversations," which is set to air February 27 at 10 p.m. ET on OWN.

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The idea of a possible Winfrey 2020 presidential campaign was buzzing following the Cecil B. DeMille Award acceptance speech she gave at the Golden Globes last month. Two friends close to Winfrey previously told CNN that she was "actively thinking" about running for president and that some of her confidants had been nudging her privately to make a run.

However, Winfrey said in an interview with InStyle Magazine that she didn't intend to run.

"I've always felt very secure and confident with myself in knowing what I could do and what I could not," she told the magazine. "And so it's not something that interests me. I don't have the DNA for it."

Winfrey has repeatedly said in the past that she has no plans to run for office.