Girdin detection

GIRDers of actIN filament (Girdin) belongs to a family of proteins characterized by the presence of a coiled-coil domain. Girdin is an actin-binding protein that is activated by the serine/threonine kinase Akt. Girdin is a key modulator of the AKT-mTOR signaling pathway that controls the timing of newborn neuron integration during adult neurogenesis, including correct neuron positioning, dendritic development, and synapse formation.

GIRDers of actIN filament (Girdin) belongs to a family of proteins characterized by the presence of a coiled-coil domain. Girdin is an actin-binding protein that is activated by the serine/threonine kinase Akt. Girdin is a key modulator of the AKT-mTOR signaling pathway that controls the timing of newborn neuron integration during adult neurogenesis, including correct neuron positioning, dendritic development, and synapse formation. It also enhances Akt signaling by mediating phosphoinositide 3-kinase (PI3K)-dependent activation of Akt by growth factor receptor tyrosine kinases and G protein-coupled receptors (GPCRs). Elevated levels of Girdin expression are associated with cancer metastasis. Girdin is also known as coiled-coil domain containing 88A (CCDC88A), G alpha-interacting vesicle-associated protein, Hook-related protein 1, Akt-phosphorylation enhancer (APE), GIV, GRDN, HkRP1, and KIAA1212.

These products are affinity-purified IgG antibodies that recognize human Girdin protein. The antibodies were raised in rabbit using synthetic peptides, and can be used for Western blot (WB) detection, immunohistochemical (IHC) detection, immunocytochemical (ICC) detection, or immunoprecipitation (IP) of human Girdin protein.

Girdin was identified by a study group led by Takahashi as a protein playing an important role in the infiltration and metastasis of cancer cells. It has been shown that Girdin, phosphorylated by the enzyme Akt/PKB within cancer cells, enhances the infiltration potential of cancer cells. It has, therefore, been suggested that if the activity of girdin is suppressed, it may be possible to develop a drug which can suppress the progression of cancer.

Notice to purchaser

Our products are to be used for Research Use Only. They may not be used for any other purpose, including, but not limited to, use in humans, therapeutic or diagnostic use, or commercial use of any kind. Our products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products or to provide a service to third parties without our prior written approval.

Girdin was identified by a study group led by Takahashi as a protein playing an important role in the infiltration and metastasis of cancer cells. It has been shown that Girdin, phosphorylated by the enzyme Akt/PKB within cancer cells, enhances the infiltration potential of cancer cells. It has, therefore, been suggested that if the activity of girdin is suppressed, it may be possible to develop a drug which can suppress the progression of cancer.

Notice to purchaser

Our products are to be used for Research Use Only. They may not be used for any other purpose, including, but not limited to, use in humans, therapeutic or diagnostic use, or commercial use of any kind. Our products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products or to provide a service to third parties without our prior written approval.

Alternative names

Additional product information

Please see the product's Certificate of Analysis for information about storage conditions, product components, and technical specifications. Please see the Kit Components List to determine kit components. Certificates of Analysis and Kit Components Lists are located under the Documents tab.

Takara Bio USA, Inc. (TBUSA, formerly known as Clontech Laboratories, Inc.) provides kits, reagents, instruments, and services that help researchers explore questions about gene discovery, regulation, and function. As a member of the Takara Bio Group, TBUSA is part of a company that holds a leadership position in the global market and is committed to improving the human condition through biotechnology. Our mission is to develop high-quality innovative tools and services to accelerate discovery.

FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES (EXCEPT AS SPECIFICALLY NOTED).

Capturem Trypsin provides rapid, efficient, and complete digestion of protein samples, allowing an uninterrupted mass spectometry workflow at room temperature for downstream protein analysis. This product utilizes our novel Capturem technology in a spin column format with membrane-immobilized trypsin. Capturem Trypsin Columns may be used to completely digest protein samples in less than a minute with digestion efficiencies (protein coverage) comparable to or better than those obtained using in-solution trypsin digestion.

Takara Bio USA, Inc. (TBUSA, formerly known as Clontech Laboratories, Inc.) provides kits, reagents, instruments, and services that help researchers explore questions about gene discovery, regulation, and function. As a member of the Takara Bio Group, TBUSA is part of a company that holds a leadership position in the global market and is committed to improving the human condition through biotechnology. Our mission is to develop high-quality innovative tools and services to accelerate discovery.

FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES (EXCEPT AS SPECIFICALLY NOTED).