Results-
• Nitrous oxide was not associated with mortality
• ENIGMA demonstrated a trend to a lower risk of myocardial infarction in the nitrous oxide free group.
• The long term follow up over a median of 3.5 year further demonstrated a statistically significant increase in the risk of MI in patients exposed to nitrous oxide.
• ENIGMA also highlighted a significant increase in wound infection in patients exposed to nitrous oxide.