Despite the high incidence, meniscal lesions still remain a clinical challenge due to its limited regenerative ability. In the last two decades, the development of scaffolding strategies has revolutionized meniscus treatment possibilities. Along with these new developments, the orthopaedic community has embraced the campaign “preserve the meniscus”. In this sense, acellular or cellularized scaffolds have emerged as a potential solution to treat irreparable meniscal lesions. Herein, it are overviewed the up-to-date acellular meniscal scaffolds used in the clinics, indications and discussed their outcomes.