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NAtures are simple, modest for power, timid for speed. Both hurt attack so there's no loss of natural bulk. Pressure is the only available ability, and it's saved me more than once. Items are for power or speed, your choice (no pun intended). Moves are a good assortment. Psystrike is Mewtwo's signature move, and stronger than Psychic. Aura Sphere is a great move in general, 90 power and doesn't miss. Third slot can have a variety of attacks, in this case the elemental attacks. Thunderbolt for waters and flyers, flamethrower for grass types and steels not named Heatran, and Ice Beam for Dragons. Shadow Ball gets perfect coverage with Aura Sphere, simple really.

Other Options:
Grass Knot: Only if you REALLY want to punish a Groudon.
Solarbeam: Possible I guess, but only in sun.
Thunder: Possible on a rain team or against one, otherwise use T-Bolt
Fire Blast: You can if you want power over accuracy, I'd go with Flamethrower personally.
Blizzard: Possibly useable on a hail team or against one, Ice Beam is still more reliable.
Focus Blast: Why use focus fail when Aura Sphere is available?
Energy Ball: Possible, but it's only a decent move at best.
Thunder Wave: Mewtwo is about offense. I guess you could run it, but you'd have to lose coverage to do so.
Psychic: Use Psystrike, it's stronger.
Psyshock: A weaker Psystrike. Don't use this.

This set gets so much Super effective coverage it is just downright scary, especially with the ability to switch between moves and the insane speed. It hits almost the entire Uber tier for Super Effective damage. A Timid nature helps Mewtwo outrun Timid Darkrai, Timid/Jolly Arceus, Jolly Shaymin-S, and Jolly scarf Tyranitar. After Stealth Rocks and a single Nasty Plot pass Mewtwo OHKO's almost the entire Uber tier, including Lugia by using Ice Beam, just be aware of Scarfed revenge killers and CB Rayquaza or Attack Deoxys. Only Giratina and Defence Deoxys can hope to survive after Stealth Rock and Nasty Plot.

Tension blocks berry use of the opponents, which means you can hit Rayquaza and Garchomp through their Yache berries for example, but is quite situational, as berries are very uncommon in Ubers. Pressure is on the other hand also not that good for this Mewtwo, as it is designed to outrun and OHKO pretty much everything the foe throws at it before they can even move, and that makes Pressure fairly useless.

Still, this Mewtwo basically does what Mewtwo does best: Special sweeping. With an insane Sp. Atk stat, good Speed, and a ridiculously large special movepool that allows unheard of levels of super effective coverage Mewtwo is the epitome of a fast special sweeper. Whilst it can do other things, Special Sweeping is by far the best thing Mewtwo can do.

Other options: Thunder, FlamethrowerThunder hits Kyogre hard and hits Lugia a bit harder than Ice Beam would, but if you sacrifice Ice Beam for it you lose a huge amount of super effective coverage, especially Groudon and Rayquaza can take advantage. Thunder also lacks reliability in sun, and doesn't really hit anything else of note. Flamethrower hits Metagross and Forretress hard, and gets a sun boost, but it doesn't really hit anything else of note, and both can be dealt with decently with Aura Sphere, whilst Grass types are equally hit hard with Ice Beam

A partner is Thundurus, which can use priority Thunder Wave to paralyze all scarfers that could potentially revenge kill Mewtwo. Also, a Sp.Atk passer like Baton Pass Nasty Plot Mew can be useful, as after Mewtwo receives a single Plot boost, it achieves world domination. Stealth Rock layers also help Mewtwo, as with Stealth rock support it can OHKO so much more (especially Lugia, where it cancels Multiscale).

Mewtwo. The first "evil" Pokémon, made to be the strongest in the world. And when it first appeared in the days of R/B/Y, it was well worthy of that title. Even with low Attack and Defense, and in spite of the Psychic type being horrendously overpowered, Mewtwo had the highest Special stat in the game, and the moveset to utilise it. Virtually nothing could counter it. However, as the generations went on, Mewtwo got nerfed A LOT. The introduction of Dark and Steel types, the Special stat being split (resulting in a low Special Defence), the introduction of more Pokémon that were just as/even more powerful than Mewtwo and the Psychic type's initial weakness, Bug, getting stronger... Despite this, the super-Mew remained a threat in Ubers. Then Gen V gave it it's own signature move, Psystrike. This attack meant that Mewtwo's old arch-enemy, Blissey, was no longer safe. Despite his fall from grace, Mewtwo is still a very dangerous enemy to face.

Probably one of Mewtwo's most dangerous sets. Psystrike takes care of walls like Blissey or Eviolite Chansey and gives STAB, while Ice Beam or Flamethrower provides additional coverage, Flamethrower being useful against the likes of Genesect. Shadow Ball also provides coverage, drawing from Mewtwo's excellent Special Attack, and Aura Sphere stops those pesky Dark and Steel types. Alternatively, Recover can be used to shrug off any damage Mewtwo takes, or Calm Mind can boost Mewtwo's Special Attack to nightmarish levels.

Last edited by Spin Attaxx; 23rd December 2012 at 10:03 PM.

Shokotan: "And then, in Extremespeed Genesect: The Awakening of Mewtwo, we meet another Mewtwo!"
Yuyama: "Yes, I thought it'd be better if it was a different Mewtwo."

Good for you Yuyama. Too bad you've singlehandedly torpedoed any lingering respect I and anyone else had for you.

Mewtwo could have made the Mayan apocalypse happen. But no, it didn't
Mewtwo is the original Uber. It is one powerful offensive juggernaut. The stats tell the entire story. 154 special attack and 130 speed as bases is very scary. The addition of Psystrike adds to the amount of damage this thing can deal. The movesets this guy can and will use are kind of obvious, so I won't post any.

A slightly defensive set which still packs a punch. Def Evs allows Mewtwo to survive some attacks. Protect if you want to lower pokemon's PP a lot thanks to Pressure. Recover if you want more HP. Then Calm Mind makes you more defensive and more powerful. Psystrike with Aura Sphere makes for some good coverage for almost all types.

Mewtwo has returned this generation, even more unstoppable than before. Its new signature move, Psystrike, acts as a more powerful Psyshock, allowing it to 2HKO its formerly biggest enemy, Blissey, as well as the newcomer Chansey, after a boost.. This, coupled with the rest of its excellent movepool, very high Special Attack, blazing speed, and decent defenses make it among the most dangerous and best Pokemon in the game, its only true flaw being its Psychic-typing, which gives it a poor attacking STAB type, and a lack of resistances.

AbilitiesPressure: Good ability, considering most ubers use moves with only 8 pp.Unnerve: More or less useless. The only times this might be useful is when facing Yache Berry Rayquaza, Salamence, Garchomp, or Occa Berry Genesect or Scizor, which are rare.. Overall, I'd stick with Pressure.

Simple but deadly is the phrase that describes this set. Psystrike is the main move of this set, 2HKOing the most physically defensive Chansey after a boost and 2HKOing 4/252 Blissey even with a positive nature without a boost. Aura Sphere is preferred in the second slot, as it hits threats such as Dialga, Darkrai, Kyurem's formes, Dark Arceus, and Tyranitar. Fire Blasts however, hits Scizor, Genesect, and Ferrothorn harder while having the same coverage against Steel Arceus and Excadrill. Do note that if using Fire Blast, that Heatran will wall the set. Ice Beam is in the last slot to hit Dragons and Grounds, most notably the Latis twins, who resist all the other moves, and Ground Arceus. Shadow Ball gets better overall neutral coverage, and allows Mewtwo to beat one of its biggest counters, Psychic Arceus.

Other Options
With a movepool that compares the Arceus, Mewtwo does have many other options. It can run a bulky attacking set for use on more defensive teams with max speed and more investment in its defenses. If this is run, it is recommended to have Substitute on the set, so you can avoid status from Chansey and Blissey.
A support set is also viable, as Mewtwo has access to a lot of support moves, such as Will-O-Wisp, Taunt, and Dual Screens. The only problem with it is that Mewtwo is only slightly more bulky than Rayquaza, who is often considered to be quite frail by uber standards.

Counters
None! It is flat out impossible to safely switch into Mewtwo. The closest thing to a counter is Speicially Defensive Dark Arceus, who can switch into Psystrike, take an Aura Sphere - although it will almost kill it, an KO witha super-effective Payback. Psychic Arceus is in a similar position, but can't take a Shadow Ball, and a sun-fueled Fire Blast will hurt. Choice Scarf Darkrai can also revenge kill it or switch into Psystrike, and OHKO with Dark Pulse if Mewtwo has taken a bit of prior damage. Choice Scarf Genesect is another great revenge killer that OHKOs with Bug Buzz after a Download boost. It can also OHKO it with U-turn after a boost + a bit of prior damage.

Mewtwo: I still remember the days when it was the unquestioned best Pokemon ever. As far as I'm concerned, it still is. In the show, Mewtwo proved to be the darkest (first time anyone saw people die in the series) yet the most sympathetic (really, could you blame Mewtwo for wanting to destroy the world given his circumstances?) villain Pokemon's ever had. Mewtwo also holds the distinct honor of being the ONLY villain I've ever shed a tear for. ('Origin of Mewtwo'. Poor Mewtwo, having to watch his only friend die on him, and then being forced to forget he ever knew her... :'( ) In the games, he's unfortunately lost a lot of his former glory. Dark and Steel types were brought in to tame what was then the most feared weapon in the entire game; Mewtwo's STAB Psychic. Still, a 154 Base Special Attack and a 130 Base Speed are to be feared. Sure, KyuremB/W hits harder and Darkrai can keep up without breaking a sweat, but Mewtwo can count on outrunning any non-Scarfed Ice Dragons (or pretty much every Dragon, what with the non-Latis having Speed around the 90's) while still shredding everything in it's path. In short; if you see a Mewtwo, be prepared for a brutal fight.

No attempt to create a funny and hopefully clever pun here, just a straight-up quote from Mewtwo's own mouth describing just what kind of devastation's heading your way. Psychic used to be his most powerful attack, getting STAB and off that very high Base Special Attack...shame it never got much use competitively. But now, Mewtwo has something better, something he's lacked from the beginning; his own signature move. As stated in Heatran's POTW file last Generation, most signature moves tend to be...more gimmick than substance. Not so here; Psystrike hits with a 100 Base Power, equal to an Earthquake on something that doesn't get STAB on it (ex. Haxorus) and has 100 Accuracy. That's win/win in my books, but Mewtwo gets STAB on it...Forget SDGroudon's Earthquake, that's "I wet myself" power, especially with such a massive Special Attack behind it! And it targets the foe's Defense instead of Special Defense, which means Blissy and CMKyogre are going to die trying to stop the original Uber. Aura Sphere and Shadow Ball are for their near-perfect coverage, and the score of Super Effective hits they'll score in the Uber tier. Also, Mewtwo was throwing Shadow Balls around long before they existed; nothing can top that level of coolness. Recover is for recovery (duh). Heal off damage you've taken during your rampage and self-inflicted damage from Life Orb (an easy item to recommend, in this case). There's also something going around the internet about how Psychic and Recover were the only attacks you had to have on Mewtwo. What's that, not concerned about survival? Confident you can get a 6-0 sweep without knocking yourself out from Life Orb's recoil? Alright, alright, I hear you. Ice Beam is here if you really hate Rayquaza, Salamence, and Dragonite (if you ever see the original Dragon in Ubers). Grass Knot is if you must kill Groudon and are confident your other moves can handle everything else. (Aura Sphere slays Tyranitar faster due to a X4 Super Effective hit.) Charge Beam, as stated earlier, is gimmick; that low power won't be making any OHKOs (or any KOs) on it's own, but it'll give you a boost to your Special Attack, making your other moves much stronger. [If someone actually runs this set with Charge Beam in the final slot and wins with this, could you please post to Youtube and notify me?]
Overtyped item is overtyped, as are the Natures by this point. Speaking of Natures, I have to get the following out of my systems. Mewtwo a Timid Pokemon? HAHAHAHAHAHAHAHAHAHAHAHAHAHAHAHAHAHAHAHA!
EVs, you know the drill by now.

Other Options: Not many. The above moveset can pretty much destroy any-and-everything that either switches into the wrong move or doesn't resist anything here. Thunder is a good, standard attack that's served Mewtwo well. It just, isn't as important what with Psystrike slaying Kyogre (Thunder's main job) without worrying about Calm Mind. Focus Blast is a worse-in-every-way-except-power Aura Sphere; I don't recommend it, but someone probably will. Flamethrower/Fire Blast are for Ferrothorn, Jirachi (if you can catch it out of Rain) and not much else. Maybe Steel Arceus too, but Aura Sphere works better if it's raining.

† I am a Christian and proud of it! Copy and paste this if you are too.†

-Take up thy cross and follow Christ Jesus.
~Don't underestimate my God~
♥I believe in Jesus Christ as my Savior. If you do too and aren't scared to admit it, then copy and paste this in your signature.♥

I don't calculate stat values, I don't use cheating devices, I don't breed my way to perfection, and I don't care about natures. I catch my Pokemon the way they are, and treat them like individuals instead of brainless drones. If you use this philosophy, copy & paste this into your signature. (Started by Tyranitar, "I don't use "uber" Pokemon," edited out by me because I do use "uber" Pokemon on occasion.)

Modest
EV's 252 sp.atk, 252 speed, 4 hp
Item @ Life Orb
Psystrike
Ice Beam
Aura Sphere
Fire Blast / Guard Swap / Taunt
Mainly for coverage, again, guard swap to even out defenses around you, or Taunt to make sure no one can set up before you annihilate everyone

Mewtwo was the monster of generation one, the closest thing to real be able to call itself a truly uber legendary. Even now, Mewtwo is a sight to behold. With incredible Speed, great bulk, and one of the highest Sp. Atk stats in the game, Mewtwo dominates in any battle. Of course, with pokemon like Giratina and Luia running rampant, not as much, but still. 154 base Sp. Atk is insane. Its ability is the lam Pressure, using up 2 PP for each attack instead of one. it sucks. Anyway, it has a super versatile movepool, giving it incredible coverage. It has access to the strongest Psychic type move out there, second only to Psycho Boost.
Anyway, like I said, it has a great movepool. Aura Sphere, Shadow Ball, Psystrike, Thunderbolt, Ice Beam, Flamethrower, Energy Ball... You name, Mewtwo learns it. It evem can learn a ton of physical attacks and boasts a very decent Attack stat.
That being said, it doesn't have access to any stat boosting attacks, rendering it useless against the behemoths of Ubers, like Giratina or Lugia, who are just too bulky and can heal.
Overall, Mewtwo is one of my all-time favorites, even though I grew up with Sapphire and Emerald as my first pokemon games. While Mewtwo is no longer as menacing as he used to be with all of the new threats that dominate Ubers, he is still a force to be reckoned with.

Mewtwo... Second parts... Stop that belief, Second Parts can be better!
-Psystrike/Psychic
-Shadow Ball
-Aura Sphere
-Calm Mind/Electro Ball (old event)/Psystrike/Psychic
Pressure
252 Spe. 252 SAtk. 4 HP
Timid or Modest
Psystrike is even stronger than Psychic, and does the same as Psyshock, but Psychic can be better sometimes. Shadow Ball deals with ghosts and other Psychic types. Aura Sphere for Dark and Steel. Calm Mind raises Sp. Atk. Electro Ball, only obtainable through and old event, gets good coverage and works better with Timid.
Serebii, are my puns bad? Anyway, I'm here for movesets too.

NAtures are simple, modest for power, timid for speed. Both hurt attack so there's no loss of natural bulk. Pressure is the only available ability, and it's saved me more than once. Items are for power or speed, your choice (no pun intended). Moves are a good assortment. Psystrike is Mewtwo's signature move, and stronger than Psychic. Aura Sphere is a great move in general, 90 power and doesn't miss. Third slot can have a variety of attacks, in this case the elemental attacks. Thunderbolt for waters and flyers, flamethrower for grass types and steels not named Heatran, and Ice Beam for Dragons. Shadow Ball gets perfect coverage with Aura Sphere, simple really.

Other Options:
Grass Knot: Only if you REALLY want to punish a Groudon.
Solarbeam: Possible I guess, but only in sun.
Thunder: Possible on a rain team or against one, otherwise use T-Bolt
Fire Blast: You can if you want power over accuracy, I'd go with Flamethrower personally.
Blizzard: Possibly useable on a hail team or against one, Ice Beam is still more reliable.
Focus Blast: Why use focus fail when Aura Sphere is available?
Energy Ball: Possible, but it's only a decent move at best.
Thunder Wave: Mewtwo is about offense. I guess you could run it, but you'd have to lose coverage to do so.Psychic: Use Psystrike, it's stronger.
Psyshock: A weaker Psystrike. Don't use this.

Other Options:
Energy Ball, Thunderbolt, Ice Beam, Grass Knot, they are good special moves for coverage, but...
Focus Blast is stronger than Aura Sphere, but accuracy and PP let it down.
Mewtwo can run physical moves, but is far weaker at that, although still alright.
Flamethrower and Solarbeam are options if you, for an odd reason, decide to use Mewtwo in a sunny team.
Thunder for Rain.

Aura Sphere should be the primary steel type coverage move over Flamethrower. While Flamethrower does him more steel types super effectively, Aura Sphere is more reliable if you're not running a sun team, no thanks to the popularity of Kyogre.

Shadow ball probably unwanted. I'm not familiar with the Uber metagame, but from my understanding, the most common ghost weak pokemon are Giritina and Lugia, who both take more damage from Ice Beam.

Mewtwo does know Light Screen and Reflect, and carries a blazing fast speed. Though Deoxys-S does do a better job at this, thanks to the fact that it outruns the entire metagame, Mewtwo does have a massive special attack and much, much better defenses.
Dual Screener
Mewtwo @ Light Clay
Timid/Hasty
252 sp.att/252 speed
-Reflect
-Light Screen
-Psystrike
-Aura Sphere/Flamethrower/Ice Beam/Explosion

Reflect and Light Screen are excellent support moves for offensive teams, and they give set up sweepers much easier times preparing to sweep. Psystrike is Mewtwo's most powerful STAB, while Aura Sphere and Flamethrower can be used for coverage. Ice Beam is viable(I think) since the tier is plagued by dragon types such as Rayquaza, and Explosion is excellent for getting another sweeper in safely.

EVs can be fiddled with to increase it's bulk or attack.

Finally, I have a pretty decent set name for this week.
"Psystrike Gengar Style"

An absolute monster! No Pokemon is a better Special Sweeper, except for maybe Kyogre. Possessing a base 154 Special Attack (higher than Kyogres!), a lightning fast base 130 Speed, great HP, passable Bulk and even a usable attack stat, Mewtwo is a perfectly balanced god. Don't think it's a Special Sweeper only though, the good bulk allows it to pull of a more than brilliant Support set. Mewtwo, it may no longer have the same typing and base stat total as Arceus or Kyurem, but it is still one of the greatest pokemon ever!

Taunt prevents hazards and status. Recover heals yourself. Toxic or Will-O-Wisp... Will-O-Wisp goes well with Thunder Wave for a Pseudo-Double Powder. See, if you Will-O-Wisp like Zekrom or something, it will most likely switch since it's useless. Thunder Waving right after the Wisp will paralyze the switch in hopefully. Even if they dont switch, they probably wont damage you too much, so don't worry too much. Toxic ridicules walls not named Ferrothorn.
Reflect boosts your defense if your not running Will-O-Wisp, even if you are, it's not as good as...
Light Screen. Protection from the omnipresent special attacks. Great!
Psystrike is your strongest STAB and kills special walls. Radical.
Thunder Wave for Pseudo-Double Powder
Fire Blast kills Ferrothorn.

Offensive Mewtwo - Timid is neccesary as there's Pokemon like Darkrai and Shaymin-S directly below it's speed tier. Evs are simplez! Calm Mind to boost Sp. Atk to ridiculous levels. Leftovers provides a little health recovery, enough to just maybe grab another CM boost. Psystrike is STAB and will hit the blobs as well as Pokemon like Kyogre and Ho-oh hard, Aura Sphere pairs well with it and hits Dialga, Darkrai, and the odd Tyranitar hard. Last slot normally goes to Ice Beam - super effective damage on many of the plethora of Dragon types (bar Pokemon such as Palkia and Kyurem), but Shadow Ball hits opposing Psychic types like Deoxys and rival Mewtwo hard. Substitute could also be used with defensive evs and recover to attain many boosts, but ghost attacks are common, and coverage will be an issue.

Last edited by sbktdreed; 25th December 2012 at 5:07 PM.
Reason: From a recent review

Got Pokémon X. Intend to get either Omega Ruby or Alpha Sapphire.
No info about my Friend Safari.
Vivillon Pattern: Polar
Looking for nicknamed, shiny, and/or have a hidden ability in GTS and may battle at anytime.
If interested, send a private message with your ID #.

Why do you need Miracle Eye? I can guarantee you Aura Sphere will hit harder then any good dark types you'll come across in Ubers, and even if you face something like a Skuntank, you'll be giving it a whole extra turn to night slash you or something.

Though, this does bring up a point I'd like to make; A modest nature is actually extremely viable in Ubers. To give you a good taste of how fast Mewtwo is, a modest, maximum speed Mewtwo will still outrun a timid, maximum speed Latios.