5-Fluorouracil (5-FU) is an anti-metabolite that is in clinical use for treatment of several cancers. In cells, it is converted into three distinct fluoro-based nucleotide analogs, which interfere with DNA synthesis and ...

Superoxide dismutases (SOD) serve as an important antioxidant defense mechanism in aerobic organisms, and deletion of these genes shortens the replicative life span in the budding yeast Saccharomyces cerevisiae. Even though ...

Resveratrol, an important phytoalexin in many plants, has cytotoxic effects on several cancer cells. Ceramide is a significant sphingolipid which affects many signaling pathways regulating cell senescence, migration, and ...

In this study, the advanced backcross QTL (AB-QTL) mapping strategy was used to identify loci for yield, processing and fruit quality traits in a population derived from the interspecific cross Lycopersicon esculentum E6203 ...

One of the heat shock family protein (Hsp) expressing bacteria is the gram negative, periodontal pathogen Aggregatibacter actinomycetemcomitans (Aa). A. actinomycetemcomitans' Hsp is a 64-kDa GroEL-protein, which has been ...

Simple sequence repeats (SSRs) defined as sequence repeat units between 1 and 6 bp occur abundantly in both coding and non-coding regions in eukaryotic genomes and these repeats can affect gene expression. In this study, ...

Sialidases are glycohydrolytic enzymes which remove sialic acid residues from glycoproteins, oligosaccharides and glycolipids. There are 4 different sialidases known in mammalians. These are Neu1 (lysosomal), Neu2 ...

The world of small RNAs is expanding and new types of small RNAs are being identified. By using deep-sequencing techniques in addition to most abundant small RNAs; miRNA and siRNA, piRNA and tRFs were further characterized ...

Aging is referred as the time-dependent accumulation of biological and physiological changes in an organism. This complex process is the major factor that is associated with many diseases such as cancer, diabetes and ...

Staphylococci are pathogenic bacteria known to cause diseases among diferrent organisms including human. The two species Staphylococcus aureus and Staphylococcus epidermidis are well defined in human diseases although their ...

Magnetic levitation though negative magnetophoresis is a novel technology to simulate weightlessness and has recently found applications in material and biological sciences. Yet little is known about the ability of the ...

Cell adhesion to extracellular matrix is an important process for both health and disease states. Surface protein patterns are topographically flat, and do not introduce other chemical, topographical or rigidity related ...

Cell viability is defined as the number of healthy cells in a sample and proliferation of cells is a vital indicator for understanding the mechanisms in action of certain genes, proteins and pathways involved cell survival ...

The rapid progress in medicine provides an increase in both average life span but also increases number of patients who need intensive care throughout the world. The morbidity and mortality of systemic fungal infections ...

Tomato is consumed in the daily diet and has a diverse nutritional content including antioxidants, lycopene, vitamin C and phenolics. However, the content of these compounds in tomato cultivars could be higher. There are ...

Connexins (Cx) are building blocks of gap junctions that provide intercellular communication between adjacent cells. There exist 21 types of connexins in human body which are important for human physiology. Hence, in any ...

In this thesis, solamargine which is a known eggplant glycoalkaloid and has an important place for human health was characterized in eggplant. For characterization, two eggplant lines S.melongena MM738 and S.linnaeanum ...