..We suggest that BACE overexpression is not sufficient to produce beta-amyloid plaques, but simultaneous expression of BACE and its substrate (SwAPP) leads to an accelerated amyloid plaque formation...

..Nonetheless, the physiological role of the immune system in preventing AD is not fully understood. This article summarizes crucial animal and clinical data underscoring the potential of the immune system for AD treatment...

..To our knowledge this is the first report that anti-idiotypic antibodies can be used to identify binding partners for carbohydrates...

Neuronal and nonneuronal quantitative BACE immunocytochemical expression in the entorhinohippocampal and frontal regions in Alzheimer's disease

Genevieve LeubaCenter for Psychiatric Neuroscience and Service of Old Age Psychiatry, Department of Psychiatry CHUV, University of Lausanne, CH 1008 Lausanne, SwitzerlandDement Geriatr Cogn Disord 19:171-83. 2005

..Moreover, the strong expression in controls and regions less vulnerable to AD puts forward the probable existence of alternate BACE functions...

No influence of amyloid-beta-degrading neprilysin activity on prion pathogenesis

..Also, incubation times and clinical course of prion disease, as well as brain infectivity titres at terminal stage, were unaffected. These data rule out neprilysin as a major modulator of PrPSc accumulation and prion pathogenesis...

Prosurvival effect of DHCR24/Seladin-1 in acute and chronic responses to oxidative stress

..Our findings reveal a dual capacity of DHCR24/seladin-1, which appears to be involved in two mechanistically independent prosurvival effects, exerting an acute response and a chronic response to oxidative stress...