Bottom Line:
In obese patients, short-term weight loss did not change total adiponectin levels and insulin resistance, while the distribution pattern of adiponectin oligomers changed due to significant increment of HMW-A (p < 0.01) and reduction of MMW-A (p < 0.05).By multivariate analysis, final HMW-A levels were significantly related to baseline ISIOGTT and final body weight (adjusted R(2) = 0.41).Especially, we documented that HMW-A is promptly responsive to short-term weight loss prior to changes in insulin resistance, by a magnitude that is proportioned to whole body insulin sensitivity.

f1: Bivariate correlation between the Matsuda Index (ISIOGTT) and baseline (Panel a) and final (Panel b) HMW adiponectin levels in the obese population.Coefficients are discussed in the Results section.

f1: Bivariate correlation between the Matsuda Index (ISIOGTT) and baseline (Panel a) and final (Panel b) HMW adiponectin levels in the obese population.Coefficients are discussed in the Results section.

Bottom Line:
In obese patients, short-term weight loss did not change total adiponectin levels and insulin resistance, while the distribution pattern of adiponectin oligomers changed due to significant increment of HMW-A (p < 0.01) and reduction of MMW-A (p < 0.05).By multivariate analysis, final HMW-A levels were significantly related to baseline ISIOGTT and final body weight (adjusted R(2) = 0.41).Especially, we documented that HMW-A is promptly responsive to short-term weight loss prior to changes in insulin resistance, by a magnitude that is proportioned to whole body insulin sensitivity.