Clyde A. Hutchison, III, PhD

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Bio

Clyde Hutchison, III, PhD, is a Distinguished Professor at the J. Craig Venter Institute in La Jolla, California, where he is a member of the Synthetic Biology Group. He is also a consultant for Synthetic Genomics, Inc. In 1995 he was elected to membership in the National Academy of Sciences. He graduated from Yale University in 1960, with a BS in Physics. His graduate studies were in the laboratory of Robert L. Sinsheimer at Cal Tech where he finished his PhD in 1968. He was a member of the faculty of The University of North Carolina at Chapel Hill from 1968 until 2005, where he now holds the title Kenan Professor Emeritus. He has worked on the molecular genetics of bacteriophage, bacteria, and mammals. In Fred Sanger's lab (1975-6) he helped determine the first complete sequence of a DNA molecule (phiX174). He developed site-directed mutagenesis with Michael Smith (1978). In 1990 he began work with mycoplasmas as models for the minimal cell. This led to collaboration with Smith and Venter, and his current work on synthetic genomics.

Research Priorities

Understanding the minimal requirements for life

Determining functions of all genes in the minimal cell, JCVI-syn3.0.

Developing methods for genome design

Extending the design of minimized genomes to simple eukaryotes.

Modeling the minimal cell

Collaborating with other labs to build a predictive computer model of JCVI-syn3.0.