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Colonic polyps are growths on the inner wall of the colon. They appear like elliptical protrusions which can be detected by curvature-derived shape discriminators. For reasons of computation efficiency, much of the past work in computer-aided diagnostic CT colonography adopted kernel-based convolution methods in curvature estimation. However, kernel methods… (More)

We present a new method for guiding virtual colonoscopic navigation and registration by using teniae coli as anatomical landmarks. As most existing protocols require a patient to be scanned in both supine and prone positions to increase sensitivity in detecting colonic polyps, reference and registration between scans are necessary. However, the conventional… (More)

This paper reports the first IC-integrated flexible shear-stress sensor skin. By integrating both bias and signal-conditioning circuitry on-chip, the wiring of the MEMS skin is significantly simplified and reliability is improved. The circuit is first made by a commercial IC foundry (i.e., Mitel) and micromachining is done on the CMOS wafers to form the… (More)

Computed tomographic colonography (CTC) computer aided detection (CAD) is a new method to detect colon polyps. Colonic polyps are abnormal growths that may become cancerous. Detection and removal of colonic polyps, particularly larger ones, has been shown to reduce the incidence of colorectal cancer. While high sensitivities and low false positive rates are… (More)

We present some new methods for computing estimates of normal vectors at the vertices of a triangular mesh surface approximation to an isosurface which has been computed by the marching cube algorithm. These estimates are required for the smooth rendering of triangular mesh surfaces. The conventional method of computing estimates based upon divided… (More)

The centerlines of tubular structures are useful for medical image visualization and computer-aided diagnosis applications. They can be effectively extracted by using a thinning algorithm that erodes an object layer by layer until only a skeleton is left. An object point is "simple" and can be safely deleted only if the resultant image is topologically… (More)

Packaging for a large distributed sensing system is a challenging topic. Using flexible skin technology solves many of these problems. Combining with the newly developed backside contact technique, sensor packaging is made even easier by completely avoiding the fragile bonding wires. This paper describes the improved flexible MEMS technology and its… (More)

Line and net patterns in a noisy environment exist in many biomedical images. Examples include: Blood vessels in angiography, white matter in brain MRI scans, and cell spindle fibers in confocal microscopic data. These piecewise linear patterns with a Gaussian-like profile can be differentiated from others by their distinctive shape characteristics. A… (More)