A Spring woman is accused of driving drunk when she swerved into a center lane and smashed into a motorcycle head on, throwing the driver 100 feet before he died at the scene, officials said.

Jennifer Lopez Harden, 35, was charged with intoxication manslaughter and taken into custody Sunday after the collision at 3 a.m. on Birnham Wood Boulevard near Riley Fuzzel Road in Spring.

She was one of more than 20 drivers that received intoxication-related charges on Montgomery County roads during its "No Refusal" weekend from Thursday to Sunday, officials said.

Spring man John McSwain, 42, was traveling southbound near Interstate 45 when a car driven by Harden passed northbound and veered into the center lane, hitting Swain's motorcycle head on, according to the Texas Department of Public Safety.

McSwain was thrown from his motorcycle, which was demolished. He died at the scene. Harden, also of Spring, and her passenger were taken to the hospital with minor injuries.

The crash is still under investigation, DPS officials said.

Ruthie Elaine Scheer, 56, is also in custody after backing up over her husband in their Conroe driveway in the 1200 block of North San Jacinto Saturday evening. Frank Scheer, 66, died at the scene after she pinned him under the car. She was found to be intoxicated at the scene and she was charged with manslaughter.

In Montgomery County, there was an uptick in drunken driving arrests at the end of the last fiscal year after a rash of intoxication manslaughter cases in 2012, according to county officials.

Between 2008 and 2011, the county saw an 80 percent drop in intoxication manslaughter cases. In 2012, the number of cases increased. Impaired drivers killed 14 people in 2012 from only two in 2011, according to data from the Montgomery County District Attorney's Office.