• Skin changes in many important ways with age. The skin becomes thinner, begins to sag, and loses its elasticity and smoothness. On the areas overexposed to UV, such as the face and the hands, pigmented age spots appear.

To counteract these unattractive changes to the skin, Sederma developed Senestem, a high-tech active ingredient proven to fade signs of senescence (the process of deterioration with age) by a breakthrough approach targeting the microRNAs, according to the company. An active ingredient targets the microRNAs to prevent the decline of protein synthesis that worsens with age and is associated with unsightly phenotypic changes. This micro approach leads to a visible macro embellishment: skin recovers its density, firmness and elasticity and age spots are lightened.

This active ingredient is the culmination of Sederma’s expertise with IRB’s exclusive HTN technology, it contends.