Although Tosoni had a brief stint with the Gulf Coast League Twins to begin the year, he spent the majority of the 2008 season assigned to the Twins' advanced A affiliate, the Fort Myers Miracle. With the Miracle, he batted .325 with one home run and 17 RBIs in the first half of the 2008 season—helping his team capture the Florida State League first-half West Division title. Along with teammates Robert Delaney, Brian Dinkelman, Jeff Manship, Wilson Ramos, Anthony Slama and Danny Valencia, Tosoni was selected to represent Fort Myers in the 2008 Florida State League All-Star game, however, a broken leg prevented him from attending. He was assigned to the Miracle's seven-day disabled list, and did not play from May 16 until August 26. For the season, his average fell to an even .300 upon his short return from the disabled list at the end of the season, however, his two run home run in the first inning was the deciding factor in the Miracle's 2-1 victory over the Dunedin Blue Jays in game one of the 2008 division playoffs.[2]

Tosoni was called up by the Minnesota Twins on April 28, 2011. Tosoni had a single in his first Major League appearance off of Tampa Bay Rays starter Jeremy Hellickson. He recorded his first RBI in the same game while going 2 for 4 with two singles. On September 27, Tosoni hit his first grand slam in a 7-4 Victory over the Kansas City Royals.