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The film is set in 2005, during the ravages of Hurricane Katrina. Nolan Hayes (Paul Walker) is the father of a newborn baby, and what should be one of the happiest days of Nolan's life quickly spirals out of control during the wake of a hurricane that floods the hospital and causes failures in the power supply. Nolan faces a life-or-death situation when no one returns to help and struggles on his own to keep his infant daughter alive inside a neonatal incubator, as minutes pass, the incubator runs out of power, and the minutes become long hours.