Welcome to Muscle Lab !!

Danuta Szczesna-Cordary, PhD Email: dszczesna@med.miami.edu Myosin Light Chain Mutant Induced Cardiomyopathies The major theme of my research regards myosin and troponin-mediated cellular events that result in sarcomere shortening and muscle contraction studied at the molecular, myofilament and organ levels. Our recent research interests concentrate on the molecular and genetic causes of cardiomyopathy with a special […]

Dr. Szczesna-Cordary and her two graduate students Yoel Sitbon and Sunil Yadav flew to Madison where they presented their research via poster presentations & oral presentations! Very interesting and nourishing intellectual trip!

Dear Mr. Yadav, As you may know the AHA frequently partners with other funding sources such as private foundations, individual donors, and corporations to share support for projects of excellent scientific merit. I am writing to let you know that your AHA award was selected to be funded with a gift from Pamela Knous. Funds […]

In their latest paper published in The Proceedings of the National Academy of Sciences USA, the Szczesna-Cordary Lab reveals the molecular mechanisms associated with MYL2- mutant dilated cardiomyopathy: http://www.pnas.org/content/early/2018/02/15/1716925115 Yuan et al. 2018 DCM + Suppl

Our graduate student Yoel Sitbon successfully passed his Qualifying Exam on 01/25/2018 untitled: “Effect of Mutations in Myosin Essential Light Chains (ELC) on the Development of Pathological vs. Physiological Cardiac Hypertrophy”. More specifically, his project will be based on the two following aims: Specific aim 1: Morphological and contractile phenotypes and myosin motor function in heart […]

Yoel’s research will focus on Essential Light Chain (ELC) mutations that lead to cardiomyopathy via changes in ELC structure, and the ability of myosin to effectively interact with actin, ultimately leading to dysregulated cardiac muscle contraction. He will also be studying how mutations in ELC regulate the Super-Relaxed State of myosin and will additionally look […]

The Szczesna- Cordary lab welcomes Ulises, undergraduate student at the University of Miami studying biochemistry and Italian! During his time in the lab, he will first be shadowing graduate students, assistant and research scientists to get more familiar with the equipment and projects in the lab and will eventually have a project on his own! […]

Jacob Rowe, first year graduate PIBS student gave his rotation symposium talk today! His project focused on two different mutations in the Essential Light Chain of myosin (A57G and D43) and how each modulate the Super Relaxed State (SRX) of myosin. Thank you for all the help and we hope you enjoyed your time in […]

We are proud to announce that Dr. Chen-Ching (Vicky) Yuan is pursuing her Post-Doctoral Fellowship at the University of Washington at Seattle in the laboratory of Dr. Michael Regnier. His laboratory studies the molecular mechanisms of cardiac and skeletal muscle disease and uses this information to develop novel gene therapies and proteins, cells and tissue engineering […]