Police have said the chances of finding Curry alive after so long in the bush is 'remote' after revealing she was battling depression.

Authorities are perplexed by the disappearance of the woman who went missing from her holiday house in a small town on the Great Ocean Road.

Widespread air, land and water searches have failed to find the avid runner, who regularly jogged long distances from the property, which was again swarming with police on Thursday as the investigation continued.

'Mrs Curry suffers from depression and is reported to be an alcoholic,' a document released by Victoria Police shows.

Inspector Peter Seel told reporters it’s possible Mrs Curry went for a run and has become disoriented in bushland.

However, the likelihood of finding her alive in the bush after at least four days is remote, he added.

'Just so many days without food, water, shelter and just the elements, makes it a grim outlook', he said.