HYPOPHOSPHATASIA

Hypophosphatasia is an inherited disorder that affects the development of bones and teeth. This condition disrupts a process called mineralization, in which minerals such as calcium and phosphorus are deposited in developing bones and teeth. Mineralization is critical for the formation of bones that are strong and rigid and teeth that can withstand chewing and grinding. The signs and symptoms of hypophosphatasia vary widely and can appear anywhere from before birth to adulthood. The most severe forms of the disorder tend to occur before birth and in early infancy.

HOW IS HYPOPHOSPHATASIA DIAGNOSED?

In children the loss of primary or baby teeth with the root intact at an early stage can be diagnosed as hypophosphatasia. In a blood test the low level of alkaline phosphatase enzyme in the serum is an indicator of this disorder. X-rays are vital and crucial in diagnosing this disease as they show bone defects clearly.

HOW IS HYPOPHOSPHATASIA TREATED?

To treat Hypophosphatasia, doctors use a drug called Asfotase alfa in the treatment of this disease.

DID YOU KNOW?

Hypophosphatasia is an inherited, progressive and lifelong disease and if left untreated can be fatal.