The Wenchuan earthquake occurred on May 12, 2008 (Beijing Time) caused great economical loss and large amount of buildings were destroyed. Many of single-story reinforced concrete industrial buildings in Hanwang town located in the highly seismic region were damaged, and the damaging phenomenons are very typical. According to the damage survey and analysis of typical seismic damage for the single-story reinforced concrete industrial buildings located in Hanwang town, the damage distribution and failure characters of these buildings are summarized in this paper. The single-story reinforced concrete industrial buildings which were designed according to current seismic design code have better earthquake resistant behavior than those old single-story reinforced concrete industrial buildings and the damaging phenomenon show some new features. Finally, combining current seismic design code of our country and the earthquake damage lessons, some reasonable suggestions on the work of seismic strengthening and earthquake resistant design of the single-story reinforced concrete industrial buildings have been given.