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In this fascinating edition of Scientia, we celebrate the ways in which cell biology, biochemistry and molecular biology have illuminated our understanding of life on Earth in addition to advancing our healthcare. We showcase the work of three researchers, each dedicated to improving our health into old-age, by investigating the biochemistry behind the ageing process. By investigating the nuts and bolts of these diseases at the cellular and molecular levels, the scientists behind these projects are opening the door to targeted therapies.

Aging is a complex process through which cumulative cellular wear and tear leaves us vulnerable to disease. One avenue for aging occurs when enzymes in our bodies break down food into energy. Dr. Matthew Hirschey and his team aim to explain the biochemistry behind how metabolism contributes to aging and how the body defends itself.

Matt Hirschey’s favorite grade school class involved what he describes as “crazy logic puzzles” in which you try to problem solve and restore the order of things. For as long as he can remember he has been drawn to the challenge of problem solving – and today it is this passion to answer some of the most challenging questions in the field of Molecular Physiology that motivates Hirschey in his work at Duke University Medical Center, where he is leading a team in FA research.