We have certain groups of Leads from certain Organisations where it seems that the IT set up is clicking/checking every link in our marketo comms - which makes their lead score go through the roof - and thsy they are always at the top of the salesreps best bets list.

Other option, in case that this group of leads are not marketing qualified for you, is to set a smart campaign on you operational folder. In the smart list put all the domains that you have problem with. On the flow step decrease their score (or make it zero).