Virtually all Natural Progesterone is made from
yams or soy. Soy and Yams contain a diosgenin which is a molecule that has the base molecule of progesterone. The
progesterone cream should not contain any mineral oil, as mineral oil blocks the absorption of progesterone. It
should contain vegetable oil instead. The correct dosage should be 500 mg/oz - 1000 mg/oz of progesterone taken
so that you initially receive 40-60 mg/day of progesterone and 20 mg/day for maintenance. The progesterone cream
should NOT contain Methyl Paraben, Propyl Paraben, Butyl Paraben or any of the related Parabens as those are estrogenic.
It should not contain certain estrogenic herbs. It should not contain stearal konium chloride since that is toxic.

by Elizabeth Smith, M.D.

Many of the companies tout that their progesterone
is made from yams or soy. However, that is the most economical way to make progesterone. All Natural Progesterone
is made from yams and/or soy. These plants contain a disogenin which has the base molecule for progesterone. In
processing, some parts of the diosgenin are cleaved off and progesterone is the result.

Yam extract, a diosgenin, is not Natural Progesterone. Thus,
some skin creams say that they contain a yam extract. According to Dr. Lee, these creams do not work well. A skin
cream containing Mineral Oil will not work. The Mineral Oil will block the absorption of the Natural Progesterone.
The skin cream should contain a vegetable oil instead.

Be careful of toxic compounds in the skin cream. Much to
my horror, one compound that we were recommending to my patients had Stearal Konium Chloride, an emulsifier. According
to the University of Texas database ingestion of 3 cc of Stearal Konium Chloride is enough to cause fatal convulsions
in an adult human.

Be careful of herbs used in the skin cream. Once again we
used a skin cream on some of our post menopausal patients that caused their uterus to get bigger. We found that
the company
had used some herbs that were estrogenic in nature.

Recently, Professor Sumpter in the U.K. discovered that Methyl
Paraben, Propyl Paraben, and Butyl Paraben are estrogen mimics and stimulate the estrogen receptor. His research
was so disturbing that the European Union inquired of the European Cosmetics and Toiletry Association whether these
common preservatives would increase the rate of breast cancer. The vast majority of hand lotions and gels contain
this preservative. We found that many Natural Progesterone creams contain this preservative as well.

The correct dose of progesterone in the skin cream is 500
mg/oz -1000 mg/oz. Initially, you can load
your body with 40-60 mg/day and maintain yourself on 20 mg/day.
In general, the ovary produces 20 mg/day of progesterone, and the placenta produces 400 mg/day of progesterone
at the height of pregnancy. Thus, the therapeutic range of progesterone is quite large.

If the dose of progesterone is too low there is no clinical
effect. If the dose is too high then the patients experience shortness of breath. If the dose is too high, the
patients will also experience an emotional depression when the progesterone is stopped. In extreme cases, when
the progesterone was 2,800 mg/oz, we have heard of some patients becoming mentally confused. The mental confusion
was reversed when the patients stopped taking the cream for several months.

Here is one vendor that we like. Women with adenomyosis seem to do better with
this product that just contains coconut oil and Natural Progesterone: