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Previous studies have shown that smoking has a significant and negative association with health-related quality of life (HRQOL). A question remains, however, as to whether this association between smoking and HRQOL differs by gender or educational level. In a new study published in Preventive Medicine, we examined this question by extracting data from the 2013 Belgian Health Interview Survey (n = 5668), which assessed HRQOL using the EuroQol 5D-5L instrument.