Abstract

The role of M. pneumoniae and Cl.pneumoniae in the development of asthma is extensively discussed. Aim: To identify serological markers of infection caused by M. pneumoniae and Cl.pneumoniae in children with asthma, with varying degrees of control. Methods: We observed 62 children, aged 6-14. The children were divided into 3 groups: 1-20(32%) children with uncontrolled run of asthma, 2 -20(32%) children with controlled run of asthma, the control group - 22(36%) healthy children. To diagnose specific Ig A,M,G to M.pneumoniae and Cl.pneumoniae ELISA method was used. Analysis of the statistical significance of differences in quality characteristics was performed by bilateral Fisher exact test. Results: Analysis of the ratio of antibodies to M.pneumoniae showed that in a group of children with uncontrolled run of asthma the combination JgM (+), JgA (+/-), JgG (+/-) was seen in 75% (95%CI= 51-91) children, compared with 25% (95%CI= 8-49) of children with a controlled run of asthma, and 13% (95%CI= 3-35) to healthy children (p1, 2 = 0,004). Analysis of the ratio of antibodies to Cl.pneumoniae showed that children with uncontrolled run of asthma have got the combination JgM (+), JgA (+/-), JgG (+/-) in 65% (95%CI= 41-84) of children compared with 25% (95%CI= 0-24) of children with a controlled run of asthma and in a group of healthy children, this combination has not been noted (p1, 2 = 0.02). Conclusions: In uncontrolled run of the bronchial asthma the frequency of detection of serologic markers of acute infection caused by M.pneumoniae 75% and by Cl.pneumoniae 65%. Mycoplasma and Chlamydia infection can cause uncontrolled bronchial asthma.