Discovery

Chronic kidney disease (CKD) affects approximately 10 % of Americans and 45 % of those over the age of 65 years. Abnormal phosphorus metabolism resulting from loss of kidney function is a critical factor in developing CKD-mineral bone disorder (CKD-MBD), characterized biochemically by an increase in serum fibroblast growth factor-23, parathyroid hormone, and phosphate, and a decreased level of 1,25-dihydroxyvitamin D. Consequences of CKD-MBD include bone disease and fracture, vascular calcification and cardiovascular disease, and ultimately increased mortality. In addition, serum phosphate is positively related to mortality in the non-CKD general population. My research program focuses on elucidating factors that influence and regulate intestinal absorption of dietary phosphorus using human clinical studies and translational research studies in animal models. The goal of this work is to develop strategies to control abnormal phosphorus metabolism and its consequences in CKD patients, as well as in the general population.

Additional research interests include: nutrition for optimal pediatric bone acquisition, and effects of obesity and diabetes on bone mass and quality.