Adequate wound care is needed on wound-healing process. Applying topical agent is one of the wound care methods. Yellow potato (Solanum tuberosum L.) gel’s content an anotsianin antioxidant that could improve vascularization, initiation DNA synthesis, and stimulate synthesis of fibronectin. Therefore, it is possible that yellow potato gel could help on wound healing process. This study examined the effect of yellow potato gel on wound healing. This study was laboratory experiment with completely randomized design conducted in Department of Anatomy, Physiology and Cell Biology, Faculty of Medicine, Universitas Padjadjaran; Anatomical Pathology Laboratory, Universitas Padjadjaran; and Singaperbangsa Pharmacy Laboratory, Universitas Padjadjaran, Bandung. The study was conducted from May to October 2015. Thirty six male Swiss Webster mice (Mus musculus) were divided into 2 groups: the experimental group, which received a topical application of yellow potato gel and the control group without gel application. The observationsscar width and histological were conducted on days 7, 14, and 25. Histological preparation was made to calculate the fibroblasts, blood vessels, and epithelial thickness. The result of this study showed that topical application of the yellow potato gel evidently increased effectiveness of fibroblasts and blood vessels development on days 7. More over, it was also shown improvement in epithelial thickness and scar width on days 7, 14, and 25. In conclusion, yellow potato gel treatment can improve the effectiveness of wound healing