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Cost of revenue was $2.7 million for the first quarter ended March 31, 2011, compared with $2.1 million for the same period in 2010. Research and development expenses were $0.2 million for the first quarter of 2011, compared with $0.6 million for the same period in 2010. General and administrative expenses were $1.9 million for the first quarter, compared with $1.7 million for the same period in 2010. Selling and marketing expenses were $1.4 million for the first quarter of 2011, compared with $1.4 million for the same period in 2010. Total operating expenses for the first quarter were $6.2 million, compared with $5.8 million for the same period last year. The primary reasons for the increase in total operating expenses are costs related to an increase in personnel, consulting costs, bad debt, and billing services.

Response Genetics’ net loss for the first quarter ended March 31, 2011 was $0.3 million, or a loss of $0.01 per share, compared with a net loss of $2.1 million, or a loss of $0.13 per share, for the same period last year.

Cash and Cash Equivalents

Cash and cash equivalents at March 31, 2011, were $1.9 million, compared to $4.1 million at December 31, 2010. During the first quarter, cash was used to fund existing operations and sales growth. As a result of increases in revenues, accounts receivable balances grew from $4.7 million at December 31, 2010 to $6.1 million at March 31, 2011. Cash collections on accounts receivables from several pharmaceutical clients with whom the Company has multi-year arrangements were not received in the first quarter. Management expects these receivables will be collected in the second quarter of 2011.

First Quarter Corporate Development Highlights

First Quarter Gross Margin and Revenue per Case - Gross margin for the first quarter of 2011 was 54.4 percent compared 51.8 percent for the fourth quarter of 2010. For the first quarter of 2011, the average revenue per case was $1,380 compared to $1,350 in the fourth quarter of 2010. Gross margin is defined as revenues less cost of revenues.

Key Appointment to Executive Management - In February 2011, the Company announced the addition of Christine Meda as the Company's president. In her role, Ms. Meda will be responsible for helping in the execution of the Company's strategy and operations on a day-to-day basis and, with her expertise in cancer diagnostics, leading the Company in new areas of the market, such as the development of companion diagnostics. Ms. Meda brings nearly 30 years of experience in strategic partnering, operations and marketing to her role at Response Genetics. Most recently, Ms. Meda was president and chief executive officer of Arcxis Biotechnologies, an early-stage molecular diagnostics company.

New Clinical Data Published – Response Genetics technology was used to support both clinical and pre-clinical research to investigate possible mechanisms of cancer progression and chemotherapy resistance. One publication showed that treatment outcome in an aggressive form of pancreatic cancer may improve by targeting drugs to tumor subtypes based on identifiable molecular differences.
1 And in another, an exploratory analysis of biomarkers revealed gene expression profiles that correlated with overall survival with lapatinib (GW572016) as a first-line therapy in patients with advanced or metastatic gastric cancer.
2

Presentation at ASCO GI - In January 2011, the Company discussed the use of predictive and prognostic markers in the treatment of esophageal-gastric cancers at the 2011 Gastrointestinal Cancers Symposium.

About Response Genetics, Inc.

Response Genetics Inc. (“RGI”) is focused on the development and sale of molecular diagnostic tests for cancer. RGI’s technologies enable extraction and analysis of genetic information from genes derived from tumor samples stored as formalin-fixed and paraffin-embedded specimens. In addition to diagnostic testing services, the Company generates revenue from the sales of its proprietary analytical pharmacogenomic testing services of clinical trial specimens to the pharmaceutical industry. RGI was founded in 1999, and its principal headquarters are located in Los Angeles, California. For more information, please visit
www.responsegenetics.com.

Forward-Looking Statement Notice

Except for the historical information contained herein, this press release and the statements of representatives of RGI related thereto contain or may contain, among other things, certain forward-looking statements, within the meaning of the Private Securities Litigation Reform Act of 1995.

Such forward-looking statements involve significant risks and uncertainties. Such statements may include, without limitation, statements with respect to the Company’s plans, objectives, projections, expectations and intentions, such as the ability of the Companyto successfully expand its sales force, to successfully implement its digital pathology initiative, to initiate multiple prospective trials, the potential of using the results of this research to be included in cancer care guidelines, to successfully initiate multiple prospective trial, to continue to provide clinical trial support to pharmaceutical clients, to enter into new areas such as companion diagnostics, and to continue to execute on its business strategy and operations, to continue to analyze cancer samples, the potential for using the results of this research to develop diagnostic tests for cancer, the usefulness of genetic information to tailor treatment to patients, the usefulness of gene profiling as a predictor of response to chemotherapy in gastric and colorectal cancers,and other statements identified by words such as “projects,” “may,” “could,” “would,” “should,” “believes,” “expects,” “anticipates,” “estimates,” “intends,” “plans” or similar expressions.

These statements are based upon the current beliefs and expectations of the Company’s management and are subject to significant risks and uncertainties, including those detailed in the Company’s filings with the Securities and Exchange Commission. Actual results, including, without limitation, actual sales results, if any, or the application of funds, may differ from those set forth in the forward-looking statements. These forward-looking statements involve certain risks and uncertainties that are subject to change based on various factors (many of which are beyond the Company’s control). The Company undertakes no obligation to publicly update forward-looking statements, whether because of new information, future events or otherwise, except as required by law.

The following details ResponseDX™ revenue for the three months ended March 31, 2010 and 2011:

Three

Months ended March 31,

Unaudited

Unaudited

2010

2011

Net Medicare revenue

$

906,785

$

1,148,963

Private Payor Revenue billed through March 31, 2010

—

1,951,310

Revenue recorded on the cash basis prior to April 1, 2010

717,284

—

NeoGenomics Laboratories revenue

90,685

—

Other

5,496

Net ResponseDX™ revenue

$

1,720,250

$

3,100,273

TABLE TWO

The following table provides details of ResponseDX™ revenue for the three months ended March 31, 2010 and 2011 based upon the former cash basis revenue recognition policy relating to Private Payors. This table is presented to provide the amount of revenue recognized if the change to the accrual basis of revenue recognition for Private Payors had not occurred effective April 1, 2010:

Three

Months ended March 31,

2010

2011(proforma)

Net Medicare revenue

$

906,785

$

1,305,883

NeoGenomics Laboratories revenue

90,685

—

Revenue recognized on the cash basis

717,284

1,629,557

Other

5,496

—

Net ResponseDX™ revenue

$

1,720,250

$

2,935,440

The increase in revenue in the three months ended March 31, 2011 of $164,833 is the difference between the Net ResponseDX™ revenue in Table One of $3,100,273 and the Net ResponseDX™ revenue in Table Two of $2,935,440.