I believe a suppressor that is built to be acurate will have a noticeable differance in tolalance. also I think when you buy a suppressor it is regestered to a single gun not multiple ones.I have one for a 338 whisper and I`m looking at a 338 edge and was told that you can`t do it legally.
robster

I have a 30 cal tiger shark and I use it on my 30-338 norma 7mm wsm and 6x47. It works great on all 3 very little difference in sound suppresson. Always buy larger supressors its easier to go down in calibers. I shoot everything with no ear protection. Buy one you will wonder why you waited so long. It makes your guns that much more pleasant to shoot.

I run 308 cans on diffrent calibers all the time, but check with the manufacture to make sure that it can handle the pressure diffrences. Some 5.56 cans will work only 5.56 and not on say a 22-250. The only one I seen was an old gemtech 308 can that didnt work real well when but on 5.56. The newer ones seem to work good on the smaller stuff . i would just make sure to get one from a good manufacture.
Jrigby