*Dept of Biosciences and Nutrition at Novum, Karolinska Institutet (KI), The Centre for Allergy Research at Karolinska Institutet, Stockholm, Sweden and being members of GA2LEN, The Global Allergy and Asthma European Network

¶Astrid Lindgren Children's Hospital, Karolinska University Hospital, Stockholm, The Centre for Allergy Research at Karolinska Institutet, Stockholm, Sweden and being members of GA2LEN, The Global Allergy and Asthma European Network

+Dept of Females's and Children's Health, KI, The Centre for Allergy Research at Karolinska Institutet, Stockholm, Sweden and being members of GA2LEN, The Global Allergy and Asthma European Network

¶Astrid Lindgren Children's Hospital, Karolinska University Hospital, Stockholm, The Centre for Allergy Research at Karolinska Institutet, Stockholm, Sweden and being members of GA2LEN, The Global Allergy and Asthma European Network

+Dept of Females's and Children's Health, KI, The Centre for Allergy Research at Karolinska Institutet, Stockholm, Sweden and being members of GA2LEN, The Global Allergy and Asthma European Network

*Dept of Biosciences and Nutrition at Novum, Karolinska Institutet (KI), The Centre for Allergy Research at Karolinska Institutet, Stockholm, Sweden and being members of GA2LEN, The Global Allergy and Asthma European Network

#Institute of Environmental Medicine, KI, The Centre for Allergy Research at Karolinska Institutet, Stockholm, Sweden and being members of GA2LEN, The Global Allergy and Asthma European Network

§Dept of Medical Genetics, Biomedicum Helsinki, University of Helsinki, and Folkhälsan Institute of Genetics, Helsinki, Finland, The Centre for Allergy Research at Karolinska Institutet, Stockholm, Sweden and being members of GA2LEN, The Global Allergy and Asthma European Network

fLung/allergy clinic at Karolinska University Hospital Huddinge, The Centre for Allergy Research at Karolinska Institutet, Stockholm, Sweden and being members of GA2LEN, The Global Allergy and Asthma European Network

**Dept of internal medicine at Huddinge University Hospital, KI, The Centre for Allergy Research at Karolinska Institutet, Stockholm, Sweden and being members of GA2LEN, The Global Allergy and Asthma European Network

fLung/allergy clinic at Karolinska University Hospital Huddinge, The Centre for Allergy Research at Karolinska Institutet, Stockholm, Sweden and being members of GA2LEN, The Global Allergy and Asthma European Network

**Dept of internal medicine at Huddinge University Hospital, KI, The Centre for Allergy Research at Karolinska Institutet, Stockholm, Sweden and being members of GA2LEN, The Global Allergy and Asthma European Network

*Dept of Biosciences and Nutrition at Novum, Karolinska Institutet (KI), The Centre for Allergy Research at Karolinska Institutet, Stockholm, Sweden and being members of GA2LEN, The Global Allergy and Asthma European Network

##Science for Life Laboratory, KI, The Centre for Allergy Research at Karolinska Institutet, Stockholm, Sweden and being members of GA2LEN, The Global Allergy and Asthma European Network

¶Astrid Lindgren Children's Hospital, Karolinska University Hospital, Stockholm, The Centre for Allergy Research at Karolinska Institutet, Stockholm, Sweden and being members of GA2LEN, The Global Allergy and Asthma European Network

+Dept of Females's and Children's Health, KI, The Centre for Allergy Research at Karolinska Institutet, Stockholm, Sweden and being members of GA2LEN, The Global Allergy and Asthma European Network

#Institute of Environmental Medicine, KI, The Centre for Allergy Research at Karolinska Institutet, Stockholm, Sweden and being members of GA2LEN, The Global Allergy and Asthma European Network

¶Astrid Lindgren Children's Hospital, Karolinska University Hospital, Stockholm, The Centre for Allergy Research at Karolinska Institutet, Stockholm, Sweden and being members of GA2LEN, The Global Allergy and Asthma European Network

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About the ERS books

The ERS Monograph is the quarterly book series from the European Respiratory Society. Each Monograph covers a specific area of respiratory medicine, providing in-depth reviews that give clinicians at all levels a concise, comprehensive guide to symptoms, diagnosis and treatment.

The ERS Handbooks are compact guides to broad areas of the respiratory field. Launched in 2010, the series now covers adult, paediatric and sleep respiratory medicine, and a companion volume of self-assessment questions is available. In 2015, the first ERS Practical Handbook, on Noninvasive Ventilation, was added to the series