A Phase II Study to Assess Acute Toxicity and Quality of Life of Patients With Carcinoma of the Anal Canal Receiving Chemotherapy and Radiation Using Helical Tomotherapy

Trial Information

A Phase II Study to Assess Acute Toxicity and Quality of Life of Patients With Carcinoma of the Anal Canal Receiving Chemotherapy and Radiation Using Helical Tomotherapy

This is a phase II study using tomotherapy for radiation treatment delivery along with
concurrent 5-FU/mitomycin C for the treatment of T2-T4 cancer of the anal canal. They
hypothesis is that helical tomotherapy could minimize radiation related toxicity by avoiding
or limiting doses to structures such as small bowel, external genitalia, skin, bladder,
rectum, and femoral neck and head. This is expected to limit or reduce treatment related
toxicity and hence prevent or reduce treatment breaks. This may result in delivery of
radical treatment with better local control and treatment outcome than using the current
radiation treatment technique at our center.

Inclusion Criteria:

- Patient should have histologically proven primary squamous carcinoma or its variant

- No history of prior malignancy.

- Patients must be free of metastatic disease out of pelvis at the time of diagnosis

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