Allows users to quantify Allele-specific expression (ASE) at both the gene and gene isoform levels. IDP-ASE integrates third generation-sequencing (TGS) and second-generation sequencing (SGS) data with a Bayesian model to determine haplotypes and measure ASE. It is useful to identify and to estimate the abundance of allele-specific isoforms. It can also calculate ASE at the gene isoform level. This tool can be applied to human breast cancer cells (MCF-7 cell line) and human embryonic stem cells (hESCs, H1 cell line).

IDP-ASE statistics

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[…] or ont alone, hybrid-seq can reduce the requirement of data size and improve the output, especially for transcriptome-wide studies. for example, a series of hybrid-seq methods (idp, idp-fusion, idp-ase) have been developed to improve the transcriptome studies to isoform levels (e.g., gene isoform reconstruction, fusion genes and allele phasing) with higher sensitivity and accuracy, […]

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Supported by the National Human GenomeResearch Institute (R01HG008759); the Multidisciplinary Lung Research Career Development Program (T32HL007638); the Presidential Graduate Research Fellowship, University of Iowa; the National Natural Science Foundation of China (No. 91540204) and the institutional fund of Department of Internal Medicine, University of Iowa.