Unicentric Castleman disease

Many people with unicentric Castleman disease don't notice any signs or symptoms. The diseased lymph node is usually located in the chest, neck or abdomen. When signs and symptoms are present, they may include:

A feeling of fullness or pressure in the chest or abdomen that can cause difficulty breathing or eating

An enlarged lump under the skin in the neck, groin or armpit

Unintended weight loss

Less commonly, fever, night sweats and weakness

Multicentric Castleman disease

Most people with multicentric Castleman disease experience:

Fever

Night sweats

Fatigue and weakness

Loss of appetite

Unintended weight loss

Enlarged lymph nodes, usually around the neck, collarbone, underarm and groin areas

Enlarged liver or spleen

Other, less common symptoms include:

Nerve damage in the hands and feet that leads to numbness (peripheral neuropathy)

Skin rash

When to see a doctor

If you notice an enlarged lymph node on the side of your neck or in your underarm, collarbone or groin area, talk to your doctor. Also call your doctor if you experience a persistent feeling of fullness in your chest or abdomen, fever, fatigue, or unexplained weight loss.

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