Children and adolescents with obstructive sleep apnea had substantial improvements in attention, anxiety and quality of life after treatment with positive airway pressure (PAP) —- a nighttime therapy in which a machine delivers a stream of air through a mask into the nose.

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Children and adolescents with obstructive sleep apnea had substantial improvements in attention, anxiety and quality of life after treatment with positive airway pressure (PAP) -- a nighttime therapy in which a machine delivers a stream of air through a mask into the nose.

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"The benefits occurred even when children didn't fully adhere to the treatment," said study leader Carole L. Marcus, M.D., a sleep specialist and director of the Sleep Center at The Children's Hospital of Philadelphia. The Sleep Center follows thousands of children and adolescents with sleep problems.

The study appears online ahead of print in the American Journal of Respiratory and Clinical Care Medicine.

Obstructive sleep apnea syndrome (OSAS) is a condition of interrupted breathing caused by a narrowing in the throat or upper airway, related to large tonsils and adenoids, obesity or other medical problems. Using continuous positive airway pressure commonly relieves OSAS in adults, in whom it has been studied extensively. However, there have been few studies of PAP in children with OSAS.

"The vast majority of children with OSAS undergo surgery on their tonsils and adenoids instead of receiving PAP therapy," said Dr. Marcus. "It is difficult to get children to wear the mask used in PAP treatments." However, surgery is not always effective in treating OSAS in children, especially in obese children," said Dr. Marcus. She added that many children who require PAP therapy have underlying chronic illnesses such as Down syndrome, or developmental delays. Furthermore, the rising incidence of obesity among children and adolescents has also increased the rate of OSAS in young people.

The current study followed 52 children and adolescents with OSAS at Children's Hospital. The patients had a mean age of 12 years old, and 10 of them had significant developmental delays. The study team assessed sleepiness, behavioral problems, attention, and quality of life at baseline and after three months of PAP treatment.

The researchers found significant improvements in attention deficits, daytime sleepiness, behaviors such as anxiety and shyness, and quality of life. Both the parents and children reported on quality of life using standardized questionnaires that asked about feelings, daily activities, getting along with other children, and keeping up with schoolwork.

"We found that improvements occurred even when children were only using PAP as little as three hours a night," said Dr. Marcus, who noted that higher compliance would be expected to yield greater benefits. She added that getting children to fully adhere to treatments requires a commitment by parents and family members to a behavioral plan that supports the treatments.

Dr. Marcus said that further pediatric sleep research is warranted, such as blinded studies to compare treatment to a placebo group and further investigations of neurobehavioral outcomes. "This study was the first comprehensive study of PAP use in children, so more research should be performed, but our results have encouraging implications for using this treatment in children with sleep apnea," she concluded.

Financial support for this study came from Philips Respironics, as well as from the National Institutes of Health. Co-authors with Marcus were Jerilynn Radcliffe, Ph.D., Sofia Konstantinopoulou, M.D., Suzanne E. Beck, M.D., Mary Anne Cornaglia, Joel Traylor, RPsgT, Natalie DiFeo, CRNP, Laurie R. Karamessinis, RPFT, and Paul R. Gallagher, M.A., all of The Children's Hospital of Philadelphia; and, Lisa J. Meltzer, Ph.D., previously from CHOP, now at Denver National Health, Denver, Colo.

"Effects of Positive Airway Pressure Therapy on Neurobehavioral Outcomes in Children with Obstructive Sleep Apnea," the American Journal of Respiratory and Clinical Care Medicine, published online ahead of print Feb. 10, 2012.

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