(CNN) -- A Continental Airlines plane crashed into a home near Buffalo, New York, late Thursday, killing 44 passengers and four crew members on board, according to New York State police.
A huge fire burns from the wreckage of Continental Airlines Flight 3407 near Buffalo, New York.

A huge fire burns from the wreckage of Continental Airlines Flight 3407 near Buffalo, New York.

Authorities said one person in the Clarence Center, New York, home was also killed. Two people in the home suffered minor injuries and were taken to a local hospital, authorities said.

Continental Connection Flight 3407, operated by Colgan Air, was en route from Newark, New Jersey, to Buffalo when it went down at around 10:20 p.m. ET. The crash occurred about seven miles from Buffalo Niagara International Airport.

Dave Bissonette, Clarence Center's natural disaster services coordinator, said it was "clearly a direct hit" on the house.

"The only recognizable piece of the plane left is the tail," Bissonette said.

The ferocity of the fire was such that officials don't expect the crash site to be safe for investigators until about noon Friday, nearly 14 hours after the crash. iReport.com: Flames rise from crash site

CNN has listened to a tape of communications between air traffic control and the flight crew. The first officer had no sign of stress in her voice initially. The plane was cleared for approach. About two minutes later, the air traffic controller came back, with stress in his voice. Radar contact was lost.

The question went out: Can other planes see anything? No one responds. The controller says they might have a plane down. The pilot's last comment was "Colgan Flight 3407." There were no sounds of distress. Video Watch video from CNN affiliate WGRZ »

Authorities said the plane went down near a local fire hall, so firefighters were quick to respond to the crash site. At least nine volunteer fire departments responded to the scene. iReport.com: Are you there? Share your story

Area resident Keith Burtis said he was driving to the store about a mile from the crash site when he heard the plane go down.

"It was a high-pitched sound," Burtis said. "It felt like a mini-earthquake." Video Watch officials on the scene: 'This is not a rescue mission' »

Shortly after the crash, Burtis said he saw a steady stream of fire trucks rush by him as smoke billowed into the sky. Other witnesses told CNN they saw the plane nose-dive toward the ground.
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According to the Buffalo News newspaper, one of the crash victims, Beverly Eckert, was the widow of 9/11 terror attack victim Sean Rooney, a Buffalo native. Eckert was traveling to Buffalo for a weekend celebration of what would have been her husband's 58th birthday.

She also had planned to take part in presentation of a scholarship award at Canisius High School that she established in honor of her late husband, the newspaper reported.

Her sister, Sue Bourque, said that while the family had not yet received official confirmation of her sister's fate, the reality was settling in. "We know she was on that plane," Bourque told the newspaper, "and now she's with him."

Twelve residents were evacuated from the area of the plane crash. Law enforcement officials are asking people not to go to the crash site in fear they may hinder the investigation.

"I felt the impact ... sounded like a large explosion," said Brendan Biddlecon, who told CNN he lives two blocks from where the plane crashed. Video Watch report from witness: "All I saw was flames" »

Biddlecon ran out his home and to within a couple hundred yards of the crash. The smoke was thick and acrid, and the heat was intense, he said. Are you on the scene? Let us know

Chris Kausner, who had a sister on the flight, rushed to the Clarence Municipal Center, where he waited for additional information after emergency teams turned him back from the scene.

"My parents are on vacation in Florida and I had to call down there and tell my father what was going on," he told CNN affiliate WIVB.

When asked how his parents were handling the news, a shaken Kausner responded "To tell you the truth, I heard my mother make a sound that I have never heard before."Video Watch victim's brother discuss delivering the tragic news to his mother »

The Erie County Medical Examiner's Office established a command post at the scene and had investigators there, a statement from the office said. Officials said relatives of passengers aboard the flight should call 1-800-621-3263 for information. Watch what iReporter captured on film

A statement from the airline said: "At this time, the full resources of Colgan Air's accident response team are being mobilized and will be devoted to cooperating with all authorities responding to the accident and to contacting family members and providing assistance to them."

Continental Airlines confirmed that the Bombardier Dash 8 Q400, a 74-seat turboprop, was operating between Newark Liberty International Airport and Buffalo.

Scandinavian Airlines (SAS) permanently grounded its fleet of Dash 8s after three crash landings during a two-month period in 2007 that were blamed on the aircraft's landing gear.

"Confidence in the Q400 has diminished considerably and our customers are becoming increasingly doubtful about flying in this type of aircraft," Mats Jansson, president and CEO of SAS, said at the time. "I have decided to immediately remove Dash 8 Q400 aircraft from service."

The National Transportation Safety Board said early Friday that was preparing a "go team" to head to Buffalo to investigate the crash.

According to the National Weather Service weather observation for Buffalo, there was light snow, fog and mist shortly before 10 p.m. Flight 3407 was originally scheduled to depart at 7:45 p.m., but it was delayed. Video Watch more on the plane crash »

"Our thoughts and prayers are with the families of the crew, the passengers and our residents on Long Street," said Clarence Supervisor Scott Blylewski.

Thursday's incident is the first fatal crash of a commercial airliner in the United States since August 2006 when Comair Flight 5191 crashed when it attempted to take off from the wrong runway.

Rep. Chris Lee, R-New York, issued a statement: "We are deeply shocked and saddened by the tragic accident that occurred tonight in Clarence. Our focus right now is on supporting the first responders on the ground and their efforts to ensure the health and safety of people in the area.

"I will do my best to provide helpful information as we learn more. Our thoughts and prayers are with the victims' families at this difficult hour."

Instead of easing toward the landing strip at a gradual descent, the nose of the plane suddenly pitched up at a 31-degree angle, far steeper than what's normal for a plane during takeoff.

At that point, it appears that the crew took over from the autopilot and rammed the throttles all the way forward, trying to prevent the plane from stalling.

Seconds later, the nose of the plane dipped dramatically. At the same time, the plane rolled to the left, its left wing dipping and the right wing pointing up. Then the plane rolled even more dramatically to the other side.

Inside the cabin, passengers and crew felt a gravitational pull of two Gs, twice the force of gravity.

The wings then came back toward level flight. But the nose of the plane still pointed down, and the plane was pointed in the opposite direction from the airport. It had reversed direction.

Continental Connection Flight 3407 also was dropping nearly 20 times faster than normal … falling 800 feet in 5 seconds. The last recorded data showed the plane 250 feet above ground level, at 115 mph, less than 5 seconds before impact.