Scholarly Works (1 results)

This article considers sample size determination for jointly testing a cause-specific hazard and the any-cause hazard for competing risks data. The cause-specific hazard and the any-cause hazard jointly characterize important study endpoints such as the disease-specific survival and overall survival, which are commonly used as co-primary endpoints in clinical trials. Specifically, we derive sample size calculation methods for two-group comparisons based on an asymptotic chi-square joint test and a maximum joint test of the aforementioned quantities, taking into account of

censoring due to lost to follow-up as well as staggered entry and administrative censoring.