cow's milk protein intolerance (CMPI)

defined as adverse reactions to cow's milk that can be reproduced
and are immune-mediated

most common immune responses are immunoglobulin E (IgE)-mediated,
cell-mediated (non-IgE), or the combination of the two

Cow's milk protein intolerance/cow's milk intolerance

not immune-mediated

said to be undefined because an immune component is not clearly
identifiable

sensitivity and allergic reaction to cow's milk protein is said to be
the most common allergy seen in infancy

incidence has been reported to be anywhere between 1.8% and 7.5%

variability in incidence reporting has been attributed to the
differences in diagnostic criteria used to identify infants with
the disorder, as well as differences in the design of studies used
to evaluate the disease

definition of CMPI/CMI does not include the symptoms of lactose intolerance
or the presence of incidental isolated GI tract infections

children with CMA or CMI can present with a variety of clinical features
that are cutaneous, GI, or respiratory in origin

most common cutaneous reactions include urticaria, atopic dermatitis,
angioedema, and contact rashes

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