GenAge entry for TOP1 (Homo sapiens)

Gene name (HAGRID: 83)

Potential relevance to the human ageing process

Main reason for selection

Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing

Description

Topoisomerases regulate the topological states of DNA. Though no direct interaction has been reported, TOP1 has been indirectly linked to WRN [487]. TOP1 may also be important in the regulation of various brain functions and its activity is age-dependent [1625]. Because TOP1 has been associated with several DNA metabolism proteins thought to play a role in ageing, it is possible that TOP1 is itself involved in human ageing, though further studies are necessary to confirm this hypothesis.