Research Projects

The MITII center research focuses on different aspects of understanding the dynamics and evolution if immune responses, with a focus on adaptive responses to influenza infection. The research consists of a tight combination of modeling and experints.

The modeling projects aim to develop a quantitative framework to describe how prior immunity affects the dynamics and evolution of recall immune responses to influenza viruses. The are currently three specific goals:

Model how prior humoral immunity affects recall response to different hemagglutinin (HA) molecules of influenza strains with a focus on antibody response.

The experimental projects aim to characterize recall immune responses to influenza. The goal is to develop quantitative models to predict vaccine efficacy. Our primary interests here are to provide the data to test and refine the quantitative models, and this will be accomplished through a comprehensive analysis of the dynamics and evolution of recall immune responses to influenza viruses. The current projects aims to