"Prisoner of Destiny" is the forty-fourth episode of the Yu-Gi-Oh! VRAINS anime. It will air in Japan on March 21, 2018.

Having learned the truth hidden by the Ignis and the truth behind the Lost Incident, Playmaker tries to persuade Varis to stop the Tower of Hanoi. Unfortunately, his words fail to convince Varis. Having been driven into a corner, Playmaker entrusts all his hopes to his new ace monster!