You will need the original datafiles from a windows install, and configure them as follows

The first time you run the application, it will create a settings folder in your home dir

~/.ja2/

In this folder, JA2 will create the configuration file

ja2.ini

The game will only work after you configure a valid path to your windows-install-datafiles in this ja2.ini - for example:

data_dir = /Applications/JaggedAlliance2/

Points of attention

Be aware that Tron's latest revision will still contain bugs. Most are discussed and solved on this forum.

When switching from fullscreen to windowed mode and back, the game will crash in tactical screen when you encounter enemies.
(just always start game and play in fullscreen, dont switch to windowed - the screenshot above is just a proof it works on OSX)

If you're having questions/trouble with compiling, read this thread - it may help you