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Shenzhen report one case of H5N6 cases, 2015-12-29 14:57:41 Ministry of Health and Family Planning Commission

clipping

Guangdong Provincial Health and Family Planning Commission on December 29 briefing, Shenzhen report one case of H5N6 cases.Patients with Wu, female, 26 years old, now living in Bao'an District of Shenzhen City. The patient in critical condition, in Shenzhen designated hospitals admitted to hospital.
Experts judged the view that this case appears as sporadic cases, the lower the risk of spreading the virus at this stage.

[Link] is a subtype of influenza A H5N6 virus, the source of the virus is poultry, resulting in a lower risk of human infection and spread. May 2014, the world's first case report of Sichuan, after the world's cases were reported in four cases. Cases were cases in close contact with people not sick. The province in December 2014, Guangzhou has reported one case.

The Centre for Health Protection (CHP) of the Department of Health (DH) has been notified of a confirmed human case of avian influenza A(H5N6) by the Health and Family Planning Commission of Guangdong Province today (December 29) affecting a 26-year-old woman in Shenzhen.
The patient lives in Bao'an, Shenzhen. She is currently hospitalised for treatment and in a critical condition.
A spokesman for the DH said, "All novel influenza A infections (including H5N6) are notifiable diseases in Hong Kong.
"Locally, we will remain vigilant and work closely with the World Health Organization and relevant health authorities to monitor the latest developments.".....

Guangdong Province in mainland China 12/29 published one case of H5N6 influenza cases, 26-year-old female worker in Shenzhen City, 12/24 the incidence of serious current situation, the authorities assess this property sporadic cases, the lower the risk of spreading the virus now.

Comment

On December 29, 2015, 1 H5N6 flu cases have been reported in Shenzhen. On January 3, the author learned from the Shenzhen Center for disease control, genome sequence analysis showed that Shenzhen H5N6 influenza virus live poultry market environment, the reported cases of viruses virus highly homologous with the live bird market environment, from the angle of Bioinformatics confirmed that the cases are due to contact with live poultry or infected the market environment. The H5N6 flu cases have been reported in Shenzhen's first, fifth H5N6 flu cases worldwide. After the case, CDC work with BGI Shenzhen, immediately to the patient swab sample and live poultry markets environment H5N6 influenza viruses isolated genome sequencing. After days and nights fighting, January 3, at 10 o'clock in the morning, completed the genome sequence analysis. Gene sequencing results show that samples of patients with H5N6 virus HA and NA genes with 2014 H5N6 virus isolated from ducks in Guangdong Province highly homologous to homology > 98%; and Shenzhen 2014 live poultry market environment highly homologous H5N6 virus isolated, homology > 98%; and Shenzhen December 2015 from environmental samples of 3 highly homologous H5N6 virus strains were isolated.

Comment

GUANGZHOU, Jan. 4 (Xinhua) -- A second human H5N6 avian flu case has been reported in south China's Guangdong Province within a week, health authorities said on Monday.
The new patient is a 40-year-old woman from Zhaoqing City. She is in a serious condition and receiving treatment in a designated hospital, said an official of the Zhaoqing Municipal Health and Family Planning Bureau.

Last Tuesday, a 26-year-old woman from Shenzhen City was confirmed with the same virus. She is also being treated in a hospital.

Health authorities in Zhaoqing have 64 people who had close contact with the patient under observation and are monitoring five poultry market workers.

The live poultry trade in a market in Zhaoqing was suspended for one week, with all poultry slaughtered and the area disinfected, said the official.

Gene analysis of a sample from the Shenzhen patient indicated her infection was from contact with live poultry or a related environment, said an expert with the Shenzhen Municipal Disease Control and Prevention Center.

People should reduce the chance of coming into contact with live poultry to prevent such infection, said the expert.

The world's first human H5N6 infection was reported in May 2014 in southwest China's Sichuan Province.

Shenzhen's first H5N6 death cases in Guangdong found the second bird flu cases, Patients with serious illness at December 30, 2015 in the afternoon after she died., 2016-01-04 22:26 Source: Nanfang Daily

Clipping:

Nanfang Daily (Reporter / flight to rain) December 29, 2015, Shenzhen reported the first cases of H5N6 flu, which is the world's first five cases of reported cases. 4, the reporter learned from the Shenzhen CDC, patients in serious condition, on December 30, 2015 in the afternoon after she died.
Female patients Wu, 26, who lives in Bao'an District, the 28th was admitted to hospital hospitals. After two days of treatment and rescue, but in the end due to a serious condition after she died. After gene sequencing analysis, the cases are due to contact with live poultry or external market environment infection. (Nanfang Daily)According to the Bureau of Zhaoqing City health-related person in charge of the case it is January 1 of the report. Hemou patients, female, 40 years old, now living in Zhaoqing City. The patient serious condition, in Zhaoqing City, designated hospitals for isolation and treatment.

Information Times (reporter Zhang Xiuli) Reporters learned yesterday from the Shenzhen Municipal Center for Disease Control, the city is now an example of H5N6 deaths. CDC confirmed afterwards from Zhaoqing City, the city report an H5N6 cases.

26-year-old female patient died

According to the official announcement, December 29, 2015, Shenzhen reported the first cases of H5N6 flu, which is the world's first five cases of reported cases. The reporter January 4, 2016 CDC learned from Shenzhen, patients with serious illness at December 30, 2015 in the afternoon after she died.

The case is female patients Wu. Wu, 26, who lives in Bao'an District, the 28th was admitted to hospital hospitals. After two days of treatment and rescue, but in the end due to a serious condition after she died. After gene sequencing analysis, the cases are due to contact with live poultry or external market environment infection.

Zhaoqing report the first case of H5N6 cases

Reporters from yesterday Zhaoqing Wei Planning Commission learned that January 1, 2016, the city report one case of H5N6 cases. Hemou patients, female, 40 years old, now living in Zhaoqing City. The patient serious condition, in Zhaoqing City, designated hospitals for isolation and treatment.

After the cases have occurred, the city immediately carry out epidemiological investigations and sample testing work on the premises disinfected. To 64 close contacts and market poultry five employees under medical observation and health monitoring work, there are 16 close contacts removed from medical observation, the 48 people still in the medical observation period, and there were no circumstances unwell.

In addition, the city associated with market requirements and patient management areas live birds implement temporary closed for seven days, the market-place slaughter of live poultry, thorough cleaning and disinfection of stalls.

Prevention tips

Remember that "three to three not"

In order to do bird flu prevention, the provincial disease control experts once again appealed to the public to do the "three to three not."

"Third, we must" is simply more wash their hands - after contact with poultry, wash hands before meals and after; to cook - poultry, eggs to fully cooked before eating; to early treatment - such as the occurrence of fever, cough , headache, general malaise and other respiratory symptoms, to early to medical institutions. Before contact with birds, to take the initiative to inform the doctor.

"Three don'ts" refers not to eat poultry died; do not buy poultry products from unknown sources; do not board in live poultry stalls, try not to direct contact with live birds.

"Safety and security don't just happen, they are the result of collective consensus and public investment. We owe our children, the most vulnerable citizens in our society, a life free of violence and fear." -Nelson Mandela

Comment

Relevant departments confirmed that contact with live poultry or patients due to external market environment infection, someone was asked to live poultry markets closed the week trading

Express News correspondent reported Zheng Yanhong Express reporter yesterday confirmed the first case of Shenzhen, the world's first six cases of H5N6 reported cases was December 30, 2015 afternoon death He died.

According to the Shenzhen Center for Disease Control about the person in charge of this case it is due to contact with live poultry market outside environment or infection. Currently, Wu are to be asked to live animal markets closed.

Express reporter learned that the patient Wu, female, 26 years old this year, who lives in Shenzhen Bao'an District, on December 28 last year, was admitted to hospitals have been very critical condition at the hospital. After two days of rescue, Wu at December 30, 2015 in the afternoon after she died.

According to the Shenzhen CDC Mahan Wu, deputy director of introduction, when the patient is discomfort in the body, the situation is already very serious before going to the hospital for treatment. "The main problem in this case is delayed Shenzhen treatment, academician Zhong Nanshan repeatedly referred to when the disease prevention and control, Tamiflu use of time, sooner or later, have a great relationship with the treatment." 马汉武 he said.

Currently H5N6 flu cases worldwide are found in six cases, the patients Shenzhen why suddenly infected with H5N6 flu? It is reported that the Shenzhen Center for Disease Control in at 10:00 on January 3 in this case completion of the whole genome sequencing. After sequencing analysis that the current market environment, the presence of outside Shenzhen live bird flu virus H5N6, reported cases of this virus and live bird markets outside environment is highly homologous virus, "From the perspective of bioinformatics confirmed cases this is due to contact with live poultry infection of the outer or market environment. "Shenzhen CDC official said.

However, Wu was diagnosed with human infection of H5N6, its more than 20 close contacts have been immediately taken to quarantine medical observation for a week, there is no abnormality. It is reported that all close contacts detection were negative, but after the quarantine, they are in good health, it is also lifting the isolation.

Since Shenzhen reported cases of this virus and live bird markets outside environment is highly homologous virus, at present, Wu are to be asked to live poultry markets closed the week trading.

After the case appeared Zhaoqing to 64 close contacts and market poultry five employees under medical observation and health monitoring work, 16 close contacts removed from medical observation, 48 people are still in the observation period, and no medical unwell Happening. Live bird markets associated with patient management areas to implement temporary closed for seven days, the market-place slaughter of live poultry, thorough cleaning and disinfection of stalls.

It is reported that the provincial Planning Commission repeatedly sent Wei expert clinical treatment and epidemic prevention and control experts to Zhaoqing guide treatment and prevention and control work.

"Safety and security don't just happen, they are the result of collective consensus and public investment. We owe our children, the most vulnerable citizens in our society, a life free of violence and fear." -Nelson Mandela

Experts have repeatedly called for change to buy live poultry slaughtering their own habits (picture). Reporter Gu Zhanxu photo

Turn of the year H5N6 caused one death and one serious injury provincial disease control: No variation to human transmission of the virus

Winter and spring high incidence of bird flu, H7N9 has slowed down, H5N6 again, "trouble" - beginning of the end of December 29, 2015, January 1, 2016, Shenzhen, Zhaoqing found two cases of H5N6 infections, causing one death and one ill. At present, six cases of H5N6 cases worldwide found three cases in Guangdong.

Yesterday afternoon, the provincial CDC chief expert, mass anti Jianfeng, director informed the media, the two cases are the property of sporadic sporadic H5N6 virus, the virus mutates to a human successor was not found, the key to preventing infection in reducing close contact with live poultry.

Last December 29, the Shenzhen Municipal report one case of H5N6 cases, patients Wu, female, 26 years old, live Bao'an District of Shenzhen City. December 24 Wu disease, but did not seek immediate medical attention, December 29 to see a doctor and be diagnosed H5N6 virus infection, admitted to Shenzhen designated hospital has now been critically ill in hospital, on December 30 died.

January 1 this year, Zhaoqing report one case of H5N6 cases, patients Hemou, female, 40 years old, living for Zhaoqing City. Hemou after onset, the primary hospital for two days, after severe illness turn go Zhaoqing City People's Hospital intensive care unit, the current condition is still heavy. Disturbing that Hemou also a maternal infection after H5N6 Caesarean section.

Virus "ferocious"

Two days in patients' lungs all white. "

It was once dreaded H7N9, mortality was 40%; In contrast, H5N6 more "evil." According to statistics, currently the world were found and confirmed six cases of H5N6 virus infection, all in China, including one case in Sichuan, Yunnan two cases, three cases in Guangdong.

Guangdong early detection of cases at 15 December 2014, the Guangzhou CDC first detected the H5N6, confirmed that 58-year-old man in Guangzhou Panyu a hill, is the world's first case of human infection with the H5N6 influenza cases survived, and then transferred to Canton Medical Institute hospital with severe respiratory medicine, through the full treatment a month cured.
According to doctors in Guangdong for three clinical description of H5N6 cases, since the detection of severe pneumonia, found that patients had lung shadows, they begin to turn white within the lungs is only one day, the next day, "all white lung", Shenzhen onset cases December 24, December 30 death, also seven days time, progress in three cases of severe pneumonia very quickly, even faster than H7N9.

Common feature

We have a history of exposure to live poultry market

And ask the virus come from, can be found in three patients have contact with live birds or live poultry market exposure history.

Qiu first patient in a long-term smoking and colon cancer surgery done, time to market to buy chicken meat to eat on the way home to the rain, began the incidence of infection process. Shenzhen Wu second patient, go to the market to buy a home to ducks. From the perspective of bioinformatics confirmed that Wu cases are due to contact with live poultry or external market environment infection. Third patients Hemou Zhaoqing, also went before the onset of the sale of live poultry markets. Disease control department detected the H5 virus from the associated environmental samples.

Do not panic too

Sporadic cases and not human to human transmission

Continuous two people infected with H5N6 virus, does that mean H5N6 bird flu virus has to infect people across racial barriers?

In this regard, Jianfeng said: "The description of H5N6 among birds has become an advantage of influenza virus strains and the virus mutates occasionally infected people." However, the public need not panic too much, molecular biology currently found in Guangdong H5N6 also is typical of Avian influenza virus, the key non-variant gene locus to obtain the ability to continue to infect humans, "but it does infect a person, worthy of attention."

In addition, Guangdong three confirmed cases, H5N6 occasionally infected people, there is variation pleasant human transmission has not occurred.

A first patient mound, all close contacts no exception; and second close contact with patients Wu crowd, no disease; third patient 64 close contacts and market poultry five employees, so far no abnormalities .

Prevention key

Reduce close contact with live poultry

Guangdong expert group's analysis: 1 to 2 months, the spread of avian influenza virus in human lower risk, but does not rule out the possibility H5N6, H7N9 and other sporadic cases arise. So, individuals how to effectively prevent H5N6 infection? Jianfeng that the reduction in close contact with live poultry is the most critical.

He pointed out that Guangdong found multiple cases, does not mean "Guangdong's most dangerous", but explain unexplained severe pneumonia in Guangdong monitor effective, virus traceability clear, case tracking in place, Guangdong has a stronger ability to find cases.

Of course, on the other hand, also with the Guangdong live poultry sales patterns. Cantonese shopping, love and live poultry and other animals close contact, and trafficking together market geese, ducks, chickens, fish and other waterfowl, the market has become mixed with a stirrer, to the virus mutating, restructuring provides an opportunity. Most people are not easy to move, but the move does not rule out sporadic cases of human infection.

Therefore, Jianfeng repeatedly called for change to buy live poultry slaughtering their own habits, focus on live poultry slaughtering, cold chain distribution, fresh listing is good to reduce human exposure to infection with the virus pattern.

Treatment is expected to

Neuraminidase inhibitor effective

Guangdong three cases H5N6,1 were cured, one case being seriously ill, one case has died, whether the clinical treatment of H5N6 have explored a trick?

In January 2015, led the call Guangzhou Institute team, Guangdong the first case of H5N6 critically ill patients successfully cured respiratory disease expert Zhong Nanshan pointed out famous, confirmed the first case of treatment, H5N6 virus as long as the early use of oseltamivir and other neuraminidase inhibition anti-viral agents, patients can cure incorrigible.

Jianfeng yesterday, citing the recent two cases further treatment of the case, said, when clinical findings in patients with influenza-like illness, fever, sore throat, muscle aches, fatigue, combined with live bird markets or history of exposure to live poultry practitioners involved in the crowd, it is recommended as soon as possible (most Well within 48 hours) with neuraminidase inhibitors, treatment success depends on early treatment.

Jianfeng reminded, there is underlying disease of the elderly, low immunity, pregnant women and other people, once infected with H5N6 virus, likely to develop into severe, it is recommended to go to the market as little as possible.

Prevention and control of bird flu three to three not

To wash hands: After contact with poultry, wash hands before meals and after.
To cook: poultry and eggs should be cooked before eating.
To early treatment: If fever, cough, headache, general malaise and other respiratory symptoms, we should as soon as possible to the nearest medical institution for treatment. Before contact with birds, to take the initiative to tell the doctor.
Do not eat dead poultry.
Do not buy from unknown sources poultry products.
Do accommodation in live poultry stalls.

"Safety and security don't just happen, they are the result of collective consensus and public investment. We owe our children, the most vulnerable citizens in our society, a life free of violence and fear." -Nelson Mandela

The world's first five cases, the first case of H5N6 flu case in Shenzhen recently died, cause for concern. Reporter January 5 from the Guangdong Provincial Disease Prevention and Control Center was informed that two cases of H5N6 case last December 29 and January 1 this year in Shenzhen and Zhaoqing found belong to sporadic sporadic cases, the risk of transmission of the virus is low at this stage, does not rule out the possibility still sporadic cases arise.

H5N6 virus is currently no "person to person"

Guangdong CDC experts have warned that reduce close contact with live poultry is key to prevention

There is no "person to person" the fundamental variation

Reporters noted that H5N6 virus is not new, foreign and Chinese have been found H5N6 bird flu virus in waterfowl.

"H5N6 is a subtype of influenza virus, the source of the virus is poultry, highly pathogenic for poultry. From our monitoring and various literature data suggest that the current H5N6 virus mutation fundamental human transmission has not occurred, but also That is, the cause of human infection and lower the risk of spread. Two cases had occurred in Shenzhen and Zhaoqing belong occasional sporadic cases. "Communicable Disease Control and Prevention of Guangdong Province, chief expert Jianfeng introduction.

Jianfeng said the influenza virus hemagglutinin is based on the virus surface (H) and neuraminidase (N) named, which has 16 subtypes H, N there are nine subtypes. Between H and N combinations can reach hundreds of different types of influenza viruses. It belongs to the H5N6 subtype of avian influenza virus.

"From a biological perspective, the virus mutates pathogen evolving process. Flu among poultry originally popular, and later by the virus mutates occasionally infected people, such as the familiar H7N9. H5N6 and other viruses for variation, we It is ready to monitor and control, and can, by taking various measures to slow down the mutation rate of the virus. "Jianfeng said.

On "Global report six cases in which patients had three cases of H5N6 in Guangdong," saying, Jianfeng stressed that the cases mentioned here refers to have been discovered and confirmed. With the development of science and technology, virus traceability clearer, more in place to track cases, Guangdong has a stronger ability to find cases.

He also revealed that in January and February will continue to distribute H7N9 influenza, "H5N6 do not say no, you may even encounter patients with H7N9 and H5N6 infection at the same time."

Reduce close contact with live poultry may be effective in preventing

Experts said that people mainly through inhalation of H5N6 avian influenza virus infection, but also through close contact with infected birds secretions or excretions (such as poultry droppings, feathers, respiratory secretions, blood, etc.), or direct exposure to the virus infection. But there is no evidence that bird flu virus can spread between people continued.

"Is clear that the two cases of recent cases have live bird markets exposure history. Patients in Shenzhen to buy duck back, patient Zhaoqing to the market. We are associated with environmental samples detected the H5N6 virus." Jianfeng said that to effectively prevent bird flu, reduce close contact with live birds and is the key.

"Earnestly implement central slaughtering of live poultry, cold chain distribution, fresh listing is a very important measure." Jianfeng emphasized that practitioners have good personal protection, such as in poultry, trafficking, sale and slaughter of staff, practitioners period to wear masks, gloves and wearing overalls.

He also cautioned that people with lower immunity such as children, pregnant women, the elderly and patients with chronic underlying disease should avoid to live poultry market activities. "Because this part of the population are likely to develop after a severe infection and even death, so be sure to do personal protection." (Reporter Cao Si correspondent Guangdong Health Letter)

"Safety and security don't just happen, they are the result of collective consensus and public investment. We owe our children, the most vulnerable citizens in our society, a life free of violence and fear." -Nelson Mandela

Ben 6 pm from Zhaoqing City health department to understand, on the 6th 15 H5N6 cases have close contacts removed from medical observation, there are currently 31 staff have been removed from medical observation, the remaining 33 are still in medical observation period, and no unwell situation. It is noted that Zhaoqing City, one case of H5N6 cases notified on the 1st female patient is still in critical condition, in Zhaoqing City, designated hospitals for isolation and treatment.

It is understood that since the 1st, Zhaoqing City health department personnel to carry out the relevant market and sampled 165 avian influenza nucleic acid testing, and market testing positive results briefing agricultural, livestock sector, will be implemented simultaneously with patient management areas associated with live poultry market temporary closed for seven days, the market-place slaughter live poultry, thorough cleaning and disinfection of stalls. Zhaoqing City, the relevant departments to deploy staff from four live poultry business market supervision working group within the city every day for 28 live bird market operators to implement "1110" system to carry out supervision and guidance of market practitioners do personal protection jobs.

According to the Guangdong provincial CDC briefing on the 5th, from monitoring and various literature data suggest that the current H5N6 virus mutation fundamental human transmission has not occurred, that is to say, lead to a lower risk of human infection and spread. Two cases had occurred in Shenzhen and Zhaoqing belong occasional sporadic cases. "

In another development, on "Global report six cases in which there are three cases of H5N6 patients in Guangdong," the problem, the Guangdong Provincial Disease Control and Prevention Jianfeng, chief expert pointed out that the cases mentioned here refers to have been discovered and confirmed. "With the development of science and technology, virus traceability clearer, more in place to track cases, Guangdong has the ability to find more cases."

According to reports, people mainly infected through inhalation of H5N6 avian influenza virus, but also through close contact with infected birds secretions or excretions (such as poultry droppings, feathers, respiratory secretions, blood, etc.), or direct exposure to the virus infection. But there is no evidence that bird flu virus can spread between people continued.

Experts said that to effectively prevent bird flu, reduce close contact with live birds and is the key. For people with lower immunity such as children, pregnant women, the elderly and patients with chronic underlying disease should avoid to live poultry market activities. "Because this part of the population are likely to develop after infection with severe and even death, so be sure to do personal protection."

Current time when winter and spring is the peak season of avian influenza. In order to do bird flu prevention, the Guangdong provincial health department recommends the general public to do the "three to three not", that is, to wash their hands - after contact with poultry, wash hands before meals and after; to cook - poultry, eggs to fully cooked before eating; to early treatment - such as the occurrence of fever, cough, headache, general malaise and other respiratory symptoms, to early to medical institutions. Before contact with birds, to take the initiative to inform the doctor. Do not eat dead poultry; do not buy poultry products from unknown sources; do not board in live poultry stalls, try not to direct contact with live birds.

"Safety and security don't just happen, they are the result of collective consensus and public investment. We owe our children, the most vulnerable citizens in our society, a life free of violence and fear." -Nelson Mandela

Between 30 December 2015 and 2 January 2016, the National Health and Family Planning Commission (NHFPC) of China notified WHO of 2 additional laboratory-confirmed cases of human infection with avian influenza A(H5N6) virus.Details of the cases

The first case is a 26-year-old female from Baoan District, Shenzhen City, with onset date of 24 December. The patient was admitted to hospital on 27 December and is now in critical condition.

The second case is a 40-year-old female from Duanzhou District, Zhaoqing City, with onset date of 22 December. The patient was admitted to hospital on 28 December and is now in critical condition.

Xinhua News Agency, Guangzhou, January 10 (Reporters Huo Siying and Xiao Sisi) - Reporters from Zhaoqing City, Guangdong Province, the First People's Hospital learned that the hospital has implemented a caesarean section was recently admitted to H5N6 cases (pregnant women), newborn screened No problems found. At 10, this patient's condition is still critical.

January 1, Zhaoqing City, Guangdong Province reported a case of H5N6 avian influenza. Reporters on the 5th in Zhaoqing First People's Hospital ICU isolation ward to see this winter in Guangdong confirmed the second case of H5N6 patients. According to hospital reports, patient Mou, female, 40 years old, on December 28 with "fever, cough six days' to respiratory medicine hospital, admission 35 weeks of pregnancy.

According to the First People's Hospital of Zhaoqing City spokesman Zhongjia Li introduced, the patient admitted to hospital the next day after doing a cesarean section, newborn screened sure there are no problems. The patient remains in critical condition, cesarean section postoperative care, pulmonary infection interactions and other organs, leading to disease more complicated. Experts from Zhaoqing City, Guangdong Province, and has conducted several consultations, and work in accordance with the Planning Commission of Guangdong Province, Wei requirements and diagnostic and treatment practices.

In addition, the hospital has taken to the isolation ward of strict hospital infection prevention and control measures, and all close contacts preventive doses of Tamiflu, close medical observation and health monitoring.

"Safety and security don't just happen, they are the result of collective consensus and public investment. We owe our children, the most vulnerable citizens in our society, a life free of violence and fear." -Nelson Mandela

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