Peyronie's disease

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Peyronie's disease is a condition that causes the penis to become bent or curved during an erection. The condition may cause pain and make sexual intercourse difficult. It does not appear to cause difficulty urinating.

Patients with Peyronie's disease develop a layer of hard, fibrous scar tissue (called plaque) on one or more sides of the penis. The plaque may look like a hard lump on the penis. When the penis becomes erect, the plaque pulls the affected area off at an angle, causing a curved penis.

Many acute cases of Peyronie's disease have been linked to penile injuries. However, the cause of many cases of Peyronie's disease is poorly understood. Researchers have suggested that factors, such as autoimmune disorders, medications, genetics, or vitamin E deficiencies, may also play a role in the development of the disorder.

Peyronie's disease has been reported in males who are 30-80 years old. It is most common in men who are 40-60 years old. Peyronie's disease is estimated to affect 0.39-0.3% of males in the United States.

In some cases, Peyronie's disease may improve without any treatment. If the condition does not improve on its own, patients typically receive oral medications. However, oral treatment is only effective during the first 12 to 18 months because this is when plaque is still forming. If medication is ineffective, surgery may be recommended.

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