DST/NRF Research Chair in Bioinformatics and Public Health Genomics, University of the Western Cape

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Alan Christoffels receives funding from Department of Science & Technology/National Research Foundation’s South African Research Chairs Initiative, South African Medical Research Council and the European Union Horizon2020.Partners

University of Western Cape

University of Western Cape provides support as a hosting partner of The Conversation AFRICA.

The Conversation is funded by Barclays Africa and seven universities, including the Cape Peninsula University of Technology, Rhodes University and the Universities of Cape Town, Johannesburg, Kwa-Zulu Natal, Pretoria, and South Africa. It is hosted by the Universities of the Witwatersrand and Western Cape, the African Population and Health Research Centre and the Nigerian Academy of Science. The Bill & Melinda Gates Foundation is a Strategic Partner. moreRepublish this article

RepublishRepublish our articles for free, online or in print, under Creative Commons licence.There’s more and more good science news coming from Africa. Romolo Tavani/Shutterstock

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It’s been a recurring refrain: Africa still lags woefully behind the rest of the world in generating new scientific knowledge.

As figures collated by the World Bank in 2014 show, the continent – home to around 16% of the world’s population – produces less than 1% of the world’s research output.

These are painful admissions to make as the continent prepares to celebrate Africa Day on May 25. But there are several projects and initiatives that offer hope amid all the bad news.

One is a major funding and agenda setting platform, the Alliance for Accelerating Excellence in Science in Africa based in Nairobi, Kenya, which was established by the African Academy of Sciences in partnership with NEPAD. It will award research grants to African universities, advise on financial best practice and develop a science strategy for Africa. It also offers an opportunity for African scientists to speak with one voice when it comes to aligning a research and development agenda for African countries.

Another is the US’s National Institute of Health and Wellcome Trust’s commitment to invest nearly US$ 200 million into Africa-led genomics projects, biobanks and training of bioinformatics personnel. This investment targets diseases that affect the African continent and gives African scientists the opportunity to set priorities with regard to health interventions and skills development.

And some countries on the continent are starting to realise just how important it is to retain talent and skills. They are investing in human capital development and building infrastructure to keep African scientists in Africa – or to attract them back home once they’ve studied elsewhere. All of this will help to shift the continent’s economies towards becoming knowledge-based.

These are all promising steps in the right direction. But more work and focus is needed across the continent.Political will lagging

The underlying reason for the dispiriting figures shared by the World Bank is multifaceted but simple: Africa does not produce enough scientists.

The continent currently has only 198 researchers per million people. That’s compared to 455 per million in Chile, and more than 4,500 per million in the UK and the US. If it’s to match the world average for the number of researchers per million people – around 1,150 – the continent needs another million new PhDs.

Political will is desperately needed to achieve that goal. It is sorely lacking in most African countries. In 2006, members of the African Union endorsed a target for each nation to spend 1% of its Gross Domestic Product on research and development. Yet as of 2017 only three countries – South Africa, Malawi and Uganda – have reached this goal.

And while more African authors are producing research and being published in international journals, a great deal of this work is being conducted in collaboration with international partners.

The vital role of international partnerships in driving innovation in Africa is unquestionable. But at the same time, the dependence on international collaboration and investment without any pan-African framework for increasing and sustaining local funding, limits Africa’s ability to drive a scientific agenda that is aligned to its specific needs.Homegrown initiatives

That’s why African-led initiatives like the Alliance for Accelerating Excellence in Science in Africa, Human, Heredity and Health in Africa Programme and the Global Emerging Pathogens Treatment Consortium – through which genomics programmes on the continent are being funded – are so important.

For instance, the funding the National Institutes of Health and the Wellcome Trust are channelling through the Human, Heredity and Health in Africa Programme has catalysed regional efforts to establish guidelines for biobanks in South Africa, Ivory Coast and Sierra Leone.

Genetic material of African origin is key to the development of more effective vaccines or understanding disease mechanisms. Biobanks provide both the infrastructure and protocols to accurately store these biological samples, and in the context of pandemics like Ebola scientists have access to the biological material to find vaccines.

In supporting biobanks and more generally genetics laboratories, my team has built the open-source Baobab LIMS through European Union funding to track the lifespan of a biological sample in a laboratory. This means a researcher can trace what happens to a biological sample or where it is located. Currently this technology is being used at labs in South Africa, Uganda, Kenya, Ivory Coast, Sierra Leone, The Gambia and Tunisia.

But building laboratories isn’t enough. To keep growing and improving its scientific output, Africa needs to pay urgent attention to retaining talent.

The continent’s unstable research funding streams mean that scientists tend to be employed only on short-term contracts. As a result, 48% of researchers in Southern Africa are spending less than two years at any one institution. This number drops to 39% for East Africa.

The impact of short-term contracts will be felt in the research and development space where we do not have sufficient time to build critical mass. This results in continuous initiation of new projects without building on existing knowledge and seeking interventions that are sustainable.

This short-term thinking also means that brilliant African thinkers and scientists are lost to the continent. And there is no doubt that retaining such scientists makes a difference. Take the case of Professor Abdoulaye Djimde. The continent needs more like him.

Djimde, one of my collaborators, is chief of the Molecular Epidemiology and Drug Resistance Unit at the Malaria Research and Training Centre University of Bamako, Mali. He returned to Mali in 2001 after completing his PhD in genetics in the US.

Over a period of 17 years, he has rolled out a research development strategy that attracted millions of dollars in investment to build infrastructure in his home country. He’s also obtained funding to develop the next generation of African scientists through the Developing Excellence in Leadership, Training and Science (DELTAS) Africa programme. The continent needs to keep more of its Professor Djimdes at home if it’s to keep growing.

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Brenda Wingfield

Vice President of the Academy of Science of South Africa and DST-NRF SARChI chair in Fungal Genomics, Professor of Genetics, University of Pretoria

Dear Alan,Thanks for this, I agree 100%.

I am not sure that any of the African economies can afford to employ any more scientists full time but at least if we could encourage governments to partner with international granting agencies and local industries we might be able to get more sustainable sources of funding and avoid the “boom and bust” with regards to research and grant funding that happens currently.

By this I mean getting governments to partner with local industries and granting agencies to ensure that the funds do not dry up. That there are then salaries, scholarships, equipment, research materials and buildings to develop sustainable institutes which will do the research Africa needs at the same time as developing the human capacity we sorely need. It will also go a long way to helping us retain the people we have.

I also think that people born and bred in Africa are more likely to succeed in leading research initiatives in Africa, rather than “importing” experts from elsewhere - who will go home. The “Africans” are already at home and less likely to leave. This is not to say that the international experts do not have a role to play but few will stay long enough to really play a part in long term sustainability.RegardsBrenda Read more 17 hours ago Report

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