Cas9 Nuclease

Active expression of the Cas9 endonuclease is a critical requirement for efficient gene editing. The Edir-R portfolio of Cas9 nuclease expression vectors includes six SMARTchoice constitutive promoter options or an inducible format, providing the felibility to select an optimal system for robust expression and maximal cleavage efficiency when Edit-R guide RNAs are introduced into the cell.

Non-targeting controls to evaluate cellular responses to CRISPR-Cas9 components in the absence of gene target-specific sgRNA.

CRISPR-Cas9 Screening Libraries

Investigation of entire gene families of biological pathways is enabled by the broad suite of custom and pre-defined libraries of CRISPR-Cas9 reagents. Both pooled and arrayed screens can take advantage of our algorithm-optimised guide RNA designs for high functionality and superior specificity.