Promethazine Hcl
Molecular Weight

Promethazine Hcl
Melting Point

Promethazine Hcl
H2O Solubility

Promethazine Hcl
State

Promethazine Hcl
LogP

Promethazine Hcl
Dosage Forms

Tablet; Suppository; Opthalmic drops; Syrup

Promethazine Hcl
Indication

For the treatment of allergic disorders, itching, nausea and vomiting.

Promethazine Hcl
Pharmacology

Promethazine, a phenothiazine, is an H1-antagonist with anticholinergic, sedative, and antiemetic effects and some local anesthetic properties. Promethazine is used as an antiemetic or to prevent motion sickness.

Promethazine Hcl
Absorption

On average, 88% of a promethazine dose is absorbed after oral administration; however, the absolute bioavailability is only 25% because of first-pass clearance.

Promethazine Hcl
side effects and Toxicity

Symptoms of overdose include mild depression of the central nervous system and cardiovascular system to profound hypotension, respiratory depression, unconsciousness, and sudden death. Other reported reactions include hyperreflexia, hypertonia, ataxia, athetosis, and extensor-plantar reflexes (Babinski reflex). LD50=55mg/kg (I.V. in mice)