A systematic review of scientific literature reveals that concerns of fish oil supplements possibly increasing bleeding risk are unfounded, according to a paper from the Danish Medical Journal.[i]

Data collected from 16 studies of people undergoing surgery found that fish oil supplementation did not, in fact, increase bleeding risk. Fish oil supplementation is associated with a reduction in platelet aggregation in healthy individuals, but that does not appear to translate into an increase in bleeding risk during surgery.

10 weeks supplementation with 2.7 grams of DHA produced greater reduction in triglyceride levels more than the same amount of EPA.

EPA and DHA have similar effect on expression of genes involved in regulating the anti-inflammatory and pro-inflammatory processes.

DHA supplementation increases the Omega-3 Index more than EPA supplementation. The Omega-3 Index is a measure of omega-3 fatty acids in red blood cells, which relates to risk for heart disease.

Since the concern about fish oil’s potential to increase bleeding during surgery has not been supported, discontinuation of the supplement leading up to surgery and other invasive procedures is not recommended.