Mar

15

Diuretics play an important role in volume management of ESRD patients receiving peritoneal dialysis. Moreover, trials such as CANUSA have shown that residual renal function (RRF) is important in decreasing mortality in PD patients. This trial addresses whether loop diuretics can both manage total body volume and preserve RRF in peritoneal dialysis patients.

Dr. Lai: Questioned how the use of diuretics would decrease mortality in dialysis-dependent patients, as indicated by the DOPPS study.Dr. Desai: Postulated that perhaps diuretics decrease intravascular volume, which could decrease the development of left ventricular hypertrophy (LVH), which is known to be an independent predictor of mortality in dialysis-dependent patients.