Sam's Town is the second studio album by American rock band The Killers, released on October 2, 2006 in the United Kingdom and the following day in the United States. Regarding the album, vocalist and primary lyricist Brandon Flowers noted that he "wanted to create an album that captured, chronologically, everything important that got me to where I am today".[15]Sam's Town is estimated to have sold over 8 million copies worldwide to date.[16]

The album takes its name from Sam's Town Hotel and Gambling Hall, a hotel-casino in Las Vegas, the hometown of the band. It is also a local nickname for Las Vegas. Sam's Town was also a huge sign that was visible by band member Mark Stoermer through his room window when he was young.

According to photographer Anton Corbijn, the band initially wanted a "chic, gypsy look," for the album, and that "out of those discussions [for the sleeve] came these elements of faded glory."[17] The album's co-producer, Flood, is dressed as a Native American in the CD booklet. The artwork inside the album booklet is taken from a Downtown Las Vegas mural painted by Suzanne Hackett-Morgan, a local painter. The cover artwork of 'Sam's Town' features model and singer Felice LaZae. Sam's Town, and each of the singles from Sam's Town, use a script typeface for the titles, Archive Roundhand Script from Archive Type, or Gigofonts' Gf Script No 2.

In the October 2006 issue of Giant magazine, Flowers was quoted as saying that Sam's Town would be "one of the best albums in the past twenty years" and in Entertainment Weekly he remarked that it would be "the album that keeps rock & roll afloat."

Flowers later said of production techniques used on the record, "We didn't use too many vocal effects. On the first album, we used auto-tune, and I didn't even realize what was going on with these machines and the computer. I was adamant about not using it this time. You really hear what my voice sounds like, for the first time."[21]

The Killers dropped a controversial song about murdered schoolgirl Jodi Jones from the album. Flowers wrote "Where Is She?" after watching a TV news report about the 14-year old's murder when on tour in Scotland."[22]

The album debuted at number 2 on the US Billboard 200 chart, selling about 315,000 copies in its first week. It became the band's second number 1 album on the UK Albums Chart, selling about 260,000 copies in its first week. It has been certified Platinum or multi-Platinum in the US, UK, Australia, Canada, Argentina, and Ireland. Sam's Town also produced multiple charting singles including the Platinum chart topping single "When You Were Young". It was the second album by The Killers to receive Grammy nominations.

In December 2009, Sam's Town was voted by Rolling Stone's readers as the most underrated album of the decade.[23]

Christian Hoard, with Rolling Stone magazine, gave The Killers' seminal concert at Madison Square Gardens three-and-a-half stars, saying "The Vegas quartet's maligned new album, Sam's Town, might pack more unfortunate big-rock bombast than its new wave debut, Hot Fuss, but it shares a generous hook quotient and a Vegas-y talent for crowd-pleasing. Before a frothy crowd, the Killers proved they've become a tight live band."[25]