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This is the 17th year Fortune has ranked the Most Powerful Women in business outside the U.S. Banco Santander group executive chairman Ana Botín repeats again as No. 1 in 2017, though she is joined on this year’s list by 11 newcomers. The 50 global businesswomen here represent 17 countries and many industries. By Christina Austin, Laura Entis, Erika Fry, Polina Marinova, and Claire Zillman. Click here for our methodology.

Gillian Tans

CEO, Booking.com, Priceline, 47

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Courtesy of Priceline

When Tans joined Booking.com in 2002, the online travel site was a small start-up in Amsterdam. Today, she is CEO—she became boss in April 2016—and Booking.com, which generates the lion’s share of Priceline’s $10.7 annual revenues, employs 15,000 people in 199 offices in 70 countries worldwide. Previously President and COO, Tans, in the past three years, has doubled the size of the organization as well as the number of accommodations on the platform to 1.3 million, more than any of its competitors. Tans is also making a push into China, which means forging a partnership with that country’s online travel leader Ctrip (led by No. 38 on this list).