Fans of “Grey's Anatomy” are dying to see Thursday night's episode, as it is the show where Dr. Preston Burke returns and lays the groundwork for Dr. Cristina Yang's exit from Seattle. Of course there are other key storylines in play in episode 10x22 as well and fans want “Grey's Anatomy” spoilers. On Wednesday, TVLine dished out some of the goods that fans won't want to miss.

Episode 10x22 is titled “We Are Never Ever Getting Back Together.” While much of the focus will be on Cristina and Burke, there are other characters front-and-center in this episode as well. The official synopsis from TV Guide teases that Meredith will help Cristina as Yang makes a big decision about her future. Derek's sister Amelia is back and they work together on a pair of conjoined twins. Jo is in the weeds as she tackles too many cases while Stephanie learns the truth about Dr. Bailey's big case with the bubble boy.

When it comes to the case that Amelia and Derek work on, it is a complicated situation where the two babies are seemingly attached at the brain. That would be why the two neurosurgeons need to work in tandem together. Amelia will be sticking around for a little bit it seems, and she will finally start to bond a bit with Meredith. How long will she stay in Seattle? That much isn't known yet, so fans will have to stay tuned.

As for Burke's return, TVLine shared the big “Grey's Anatomy” spoiler preview setting the stage for Preston and Cristina to reunite. Yang is doing a presentation and a voice from the back of the auditorium starts questioning her. It seems that she is a bit stunned to hear the voice and recognizes it, and a moment later he steps forward and reveals himself.

Other previews indicate that Burke says that he wants Cristina back. However, is it for personal or business purposes? It seems he has a project he's working on where he needs her expertise, and most would imagine she's not going to be able to resist.

The show's creator, Shonda Rhimes, teases that “It's not gonna be about whatever you expect it to be about.” Some fans have been clamoring for a romantic reunion while others anticipate this to be a professional reunion. How will it all play out? Fans will have to tune in Thursday night to find out. The big episode laying the groundwork for Sandra Oh's “Grey's Anatomy” exit airs May 1 on ABC.