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Cancer, Lymphoma and Celiac Disease

This category contains summaries of research articles that deal with cancer and lymphoma and their association with celiac disease. Most of the articles are research summaries that include the original source of the summary.

The connection between celiac disease and various types of cancer is well supported by scientific evidence. However, to date, there hasn’t been enough data to make accurate predictions of cancer risk in celiac patients. So, we don’t know exactly what the risk levels are for various types of cancer in celiac patients.

To determine which method yielded better diagnostic results, a research team set out to compare and contrast intestinal intraepithelial lymphocyte cytometric pattern with subepithelial deposits of anti-tissue transglutaminase IgA for diagnosing lymphocytic enteritis due to celiac disease.

People with celiac disease have higher rates of lymphoproliferative malignancy. Currently, doctors just don't know whether risk levels are affected by the results of follow-up intestinal biopsy, performed to document mucosal healing.

Enteropathy-associated T cell lymphoma (EATL) is a gut cancer that often ends in death. Currently, doctors have very little idea what factors might help patients survive. The way in which clinical presentation, pathological features and therapies influence EATL outcome was the subject of a recent study by a team of researchers.

Currently, there is no cure for T-cell lymphoma, and no promising treatment exists for people who suffer from this condition. However, results of a new study suggest that new treatments for T-cell lymphoma my be on the horizon.

With all the problems that go along with celiac disease, it can be hard to see any benefits to having the disease. However, it would seem that such benefits do exist: a recent study in Sweden shows that women suffering from celiac disease are actually at a decreased risk of developing breast, endometrial and ovarian cancer.

A number of studies have found higher rates of lymphoma in people with celiac disease. However, few studies make any distinction between lymphoproliferative disorders (LPDs). A team of researchers recently investigated rates of various lymphoproliferative disorders in patients with celiac disease.

A number of small studies have shown a connection between celiac disease and various gastrointestinal (GI) cancers, but the results haven't been corroborated by larger studies, or by blood and biopsy analysis of large populations. That means that researchers just haven't been able to say with certainty what the results of those smaller studies might mean about cancer risks for the larger population.

Celiac disease is associated with an increased risk of lymphoma and small bowel malignancy. Colorectal cancer is the most common gastrointestinal cancers in the United States, but most studies have not found no higher rates of colorectal cancer for people with celiac disease.

According to this study 16% of those with lymphocytic duodenosis have celiac disease.

A team of researchers recently conducted a prospective study the etiology of lymphocytic duodenosis. Among their findings are that sixteen percent of patients with lymphocytic duodenosis have celiac disease.

A team of researchers recently set out to map the IL-15–driven survival pathway in human IELs, and to determine whether IL-15 triggered pathway in human intraepithelial lymphocytes represents a possible new target in type II refractory celiac disease and enteropathy-associated T cell lymphoma.

Enteropathy associated T-cell lymphoma (EATL) is a rare type of
peripheral T-cell lymphoma that is commonly associated with celiac
disease. A group at The Newcastle Lymphoma Group in the United
Kingdom, evaluated data from newly diagnosed patients in Northern
England and Scotland between 1994 and 1998, in search of increased
overall survival (OS) rates and progression free survival (PFS) rates
for EATL patients.

People with silent celiac disease, those who test positive for celiac disease antibodies, yet show no clinical signs of the disease itself, do not face a higher risk for developing malignant cancers, according to results of a recent Finnish study.

A microscopic compound commonly found in plant-based foods reduces inflammation and prevents the formation of cancerous lesions in the colon. The tiny molecule, called quercetin, is easily absorbed when people eat fruits and vegetables, and so requires no specialized supplements or drugs.