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Ukpabio was born in the village of Mbente, Imo State, Nigeria and is married to Dr. Elijah Ukpabio. She has three children.[2]

During her early life she was educated at St. George's Catholic School in Falomo, Jinadu Anglican School in Obalende and the Methodist Girls' School in Ikot Ekpene, Akwa Ibom State, all in south-eastern Nigeria.[3]

In 1992, Ukpabio founded Liberty Foundation Gospel Ministries with the aim of spreading her often literal interpretations of the Bible to the people of West Africa.[4]

Exploiting superstitious beliefs, particularly those related to spiritual or demonic possession or witchcraft,[8] Helen Ukpabio's organisation has grown exponentionally throughout Nigeria and West Africa since its foundation. There are now major Liberty Gospel Churches in Cameroon, Ghana and South Africa as well as Nigeria. Ukpabio has published her views in several books. An example is 'Unveiling The Mysteries of Witchcraft', in which she states that:

Under the age of two, the child screams at night, cries, is always feverish suddenly deteriorates in health, puts up an attitude of fear, and may not feed very well.[2]

She also produces, through her film production company, Liberty Films, part of the Liberty Foundation Gospel Ministries franchise, a number of films to spread the view that children can become possessed by evil spirits. The most famous of these is End of The Wicked in which child actors are shown to eat human flesh and murder their parents.[9][10]

Her activities are not limited to Nigeria. Ukpabio announced she would preach in Limbe (Cameroon) to promote a program she calls "Freedom From Strong Family Darkness", October 18–22, 2017.[11]

She incites violence against imputed witches who are usually women, children and elderly persons. The people of Cameroon should resist Ukpabio. They should reject her ‘gospel’ of hate and division in families and communities. - Leo Igwe

In 2007 an Observer newspaper article claimed Ukpabio and other evangelical pastors were encouraging an upsurge in the numbers of children being accused of witchcraft and being abused and stigmatised by parents and communities as a result.[12]

In 2014, Ukpabio brought a libel case against the British Humanist Association (BHA) and Witchcraft and Human Rights Information Network (WHRIN) seeking damages of £500,000,000. Ukpabio claims that the BHA misrepresented her by saying that she ascribed certain behaviours in children to Satanic possession when she in fact attributed them to possession by 'witchcraft spirits'. The BHA described the case as libel tourism.[18] After sending a mob to disrupt a meeting led by humanist Leo Igwe in 2009, she filed a suit for $1.3 million against the government for allowing the police to protect Igwe's group. The suit was promptly dismissed.[7][19] Ukpabio also used smears against other groups of her actions, notably the non-governmental organization Stepping Stones Nigeria.[7] She has been prevented by the Home Office from entering Great Britain by revoking her visa after calls from campaigners in 2014 that she be banned from Britain on child protection grounds.[1]