This is the largest controlled multicenter crossover study using cluster randomization which showed that selective digestive tract decontamination (SDD) and selective oropharyngeal decontamination (SOD) decreased 28-day mortality by 3.5% and 2.9%, respectively. This study is important because it has enough power to detect a mortality benefit with this prophylactic antibiotic regimen.

In the age in which there is a focus on paying...

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