Corresponding Author

Competing Interests

The authors have read the journal's policy and have the following conflicts. This study was funded by BASF Societas Europea (BASF SE). A patent (“Methods and Materials for Nucleic Acid Manipulation” and EP11 165 367.1) has been filed and given the go ahead for publication. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.