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The spark that sent
Xoma(XOMA - Get Report) shares higher was the $40 million financing announced March 6. Normally, dilutive financings undertaken by money-losing biotech firms don't send stock prices higher. That's particularly true for companies like Xoma with a sad history of drug development futility.

What's different here is that Baker Bros., a well-respected and closely followed health-care hedge fund, bought half the Xoma deal. RA Capital, a Boston-based hedge fund, was also a buyer of Xoma shares in the offering, according to regulatory filings.

When Baker Bros. buys, other investors follow, especially when Baker Bros. buys big. The fund now owns about 20% of Xoma and I'm told will likely get a board seat. The fund tends to take large, long-term positions in drug and biotech companies it likes, including
Seattle Genetics(SGEN),
Incyte(INCY) and
Viropharma(VPHM).

The question you're probably asking now is, "Wait a second -- Xoma? What the hell can Baker Bros. see in Xoma?"
I wondered the same thing.

Xoma is apparently getting a new lease on life, thanks to a top-to-bottom restructuring -- a new CEO and chief medical officer, cost cutting and a new business model. Xoma is still developing the same lead drug XOMA 052 (given a new name, gevokizumab) but money-wasting efforts in diabetes and cardiovascular indications have been shelved in favor of clinical trials for Behcets uveitis and non-infectious uveitis -- both diseases of the eye.

A phase III study of gevokizumab is expected to start this summer with data likely available by the end of 2013.

Whether Xoma succeeds with gevokizumab and breaks a three-decade-long streak of internal drug development failures is still an open question, but what's different today is that the company has some big-name investor support.

Owen S. asks: "What are your predictions for the FDA drug approvals next week involving
MAP Pharmaceuticals(MAPP),
Affymax(AFFY) and
Chelsea Therapeutics(CHTP). And how do your predictions match up with investors you talk with on Wall Street?"

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