Received date: April 04, 2018; Accepted date: April 16, 2018; Published date: April 20, 2018.

Annotation

The actual task of modern medicine is the early diagnosis of diseases, as well as monitoring the state of the exposed disease and the efficiency of drugs taken with a therapeutic purpose at the supra molecular level.

The man is a complex nonlinear system consisting of a large number of different functional structures.

Blood system, nervous, endocrine and pulse systems support the information balance in the body, modeling and compensating signaling effects on each other.

The blood is an organ that instantly perceives and deposits information of all the processes of the holistic organism in the past, present and future at the supra molecular level simultaneously, that is a main unit of "blood system" which is available in the study and correction from birth to the last minutes of life.

It has been established that cardiovascular, nervous and lymphatic systems, as well as formed blood elements are LEDs around which the evanescent (damped) waves are formed that are perpendicular to the external surface of the vessels, capillaries, nerve roots when being exposed by electromagnetic waves on any zone of skin surface, i.e the holistic organism starts operating the mode of the "scanning tunnel microscope."

Therefore, the infrared spectroscopy of the total disturbed internal reflection when touching the infrared fiber of the skin surface is unique, not traumatic, requiring no special skin preparation is a "blood Spectro biopsis" from the diagnostic zones and the zones of Ged-Zakharin on the skin surface of a living organism in a normal state, can diagnose the pathology of organs and systems at the atomic level with a high accuracy, as well as identify early disease stages, intermediate states of developing pathology and their reduction. This is a new progressive trend in medicine.

Keywords:

evanescent waves, scanning tunnel microscope, blood spectro biopsis.

As any medicinal drug enters the organism, during its entire movement path it is exposed to complex physicochemical changes with the formation of reversible and irreversible compounds (intermediate formations) with obligatory allocation of a certain energy for continuation of the cyclic process of transition from one state to a subsequent one before leaving the holistic organism [1,2].

At the same time, it should be noted that the speed, scale, content and the duration of emergence of intermediate formations of a medicinal drug in the body are strictly individual for each patient [2].

All medicinal drugs interacting with the organism should be investigated by fast, safe and highly informative methods in accordance with pharmacodynamics and pharmacokinetics, prior to their introduction into medical practice.

The adherence to this concept helps ensure a high therapeutic effect, primary and secondary prevention of diseases, prevention of complications and side effects on the organism [3].

The organism takes any substance from the outside as a foreign body, therefore a system for getting rid of this foreign body instantly begins to function. Even organism’s own blood outside the vascular bed is a foreign body for the organism. That means, the work of all organs and systems of the organism instantly enters an abnormal mode.

We should note that at the current level of the medical science development there are no methods for determining the time level of the cycle of each system: at the moment of the drug’s effect on the organism, during its transition states at the supramolecular level and after the return of all systems to their normal functional mode [3].

In this regard, it is difficult to conceive the advantage of a specific medicinal substance and, particularly, for a specific patient.

It is known that the finite characteristic of any medicinal substance at the supramolecular level is “energy” which is hard to measure and control for the purpose of therapeutic treatment: that is the reason for the lack of such data characteristics in the global medical and pharmaceutical literature.

Modern global pharmaceutical science does not have such high-level control over the movement path of medicinal substances within the organism [4].

It is known that blood is a liquid tissue circulating through vessels and carrying out physiological functions at the cellular level:

1.respiratory – the transfer of oxygen from the lungs to the tissues and of carbon dioxide from the tissues to the lungs;

2.nutritional – the delivery of nutrients, vitamins, mineral salts and water from the digestive organs to the tissues;

3.excretory – the removal of metabolic end-products, excess water and mineral salts from tissues;

8.creative - transfer of macromolecules engaged in intercellular communication of information for the purpose of the restoration and maintenance of the structure [3].

In this regard, it should be considered that blood instantly receives and deposits the information on all processes of the holistic organism in the past, present and future simultaneously, at the supramolecular level, which means that blood is the main link of the “blood system” available for research and correction from the moment of birth until the last minutes of life.

The Japanese scientist Suti experimentally proved that the outer layer of epidermis is very dry, but found a lot of cavities with intercellular fluid immediately under the second layer that led to a sharp decrease in resistance.

The thickness of epidermis on the palm is 200 µ, 120 µ for a nail wall, and 45 µ for a forearm; the average depth where the resistance sharply decreases was equal to 350,170 and 50 µ, respectively.

According to the obtained results, Suti concluded that the point of sharp decrease in resistance lies on the outer surface of the stratum germinativum and that epidermis is divided into a dry outer layer and a very wet inner layer. Suti also discovered the fact that no stronger liquid filtration from dilatated vessels of the skin in case of its exposure to heat was observed. This confirms the autonomy of the insensible transpiration system.

Even a maximum amount of liquid evaporation through the sweat pores, apparently, is only a small part of total insensible transpiration volume, since the total surface of sweat pores is very small and amounts to about 90 sq.cm, whereas the entire surface of the body is equal to 1.8 sq.m [5].

It is well known that water exudation can be observed on corpses. However, the amount of exudating water in this case is smaller than upon insensible transpiration of a living person, still this fact proves that water penetrates through epidermis.

Even at the time of Hippocrates people knew that water vapor was removed from the body through the skin.

Galen pointed it out that transpiration, insensible as it was, happened all the time on the entire body surface [5].

In this regard, it should be noted that blood is the only one of all the internal organs and systems of a living organism that has a direct and reverse connection with the outside world through the insensible transpiration system.

Therefore, there are reasons to state that any effect on the skin of a living organism is instantly transmitted to the “blood system” through the constantly existing “blood-insensible water vapor-external agent” contact.

In this regard, an experiment was conducted: a research of “spectrobiopsy” of blood from the non-irradiated skin surface of a palm. Figure 1

Figure 1: IR spectrobiopsy of blood from the non-irradiated skin surface of a palm.

The significant difference in spectrobiopsy data of blood taken from both sides of non-irradiated palm skin surface (palmar and dorsal) indicates that each diagnostic area and the Zakharyin-Ged zones denoting the projections of internal organs to the skin surface have individual, unique blood spectrobiopsy: this is a very important and promising fact for creation of a data bank of variants of normal blood spectrobiopsy.

In order to identify the mechanism of external influences on the holistic organism, the following experiments were conducted at the Fiber Optics Research Center of Russian Academy of Science, Moscow:

A significant increase in light transmission across the entire length of the spectral range of 3-15 μm was found on the inner surface of the right arm (Figure 2) and a pronounced increase in light transmission was found on the inner surface of the left wrist joint (Figure 3).

Figure 2: IR spectrobiopsy of blood from the inner skin surface of the right arm before and after exposure to amber light of 480-3,400 nm for 10 minutes.

Figure 3: IR spectrobiopsy of blood from the inner skin surface of the left wrist joint before and after exposure to amber light of 480-3,400 nm for 10 minutes.

This evidence acts in confirmation of our theory that the “blood system” (Figure 4), nervous, lymphatic systems and the complex structure of a blood vessel wall (Figure 5) are all light conductors and form evanescent waves when exposed to electromagnetic waves. In other words, the holistic organism can operate as a “scanning tunneling microscope.”

Therefore, it should be assumed that all existing non-invasive medical diagnostic investigations of the skin surface are a part of the data bank of blood of the living holistic organism.

So, there is a scientific need to establish a classification of all non-invasive diagnostic and treatment methods of the skin surface in accordance with the international classification of diseases.

It is known that light in the glass-air boundary at an excessively large angle does not come outside and is reflected inside the glass: this is called total internal reflection. However, if you bring one more piece of the same glass on the other side, so that an air gap with the thickness of about one micron is left, the light can partly overcome this previously impenetrable barrier and jump into the second piece of glass. This phenomenon is called attenuated total internal reflection, i.e. tunneling [6].

The state of light in the gap between the glasses is unusual – an evanescent (decaying) wave. It decays exponentially upon removal from the boundary, but if it reaches the second glass, there it already turns into normal light.

It has been determined that while any electromagnetic wave passes through a light guide, evanescent waves are always formed around the light guide and are directed perpendicularly to the outer surface of the light guide, then evanescent waves decay when removed from the light guide. These previously unknown properties of light have been recently discovered by the scientists from the United States, Ukraine, Japan and Korea.

Unlike normal waves, these ones are very difficult to record, because as their distance from the object increases, they decay exponentially, i.e. so fast that they never reach the image surface.

Stephen Mendak et al. from Germany have created a special “superlense” system capable of collecting and using evanescent waves.

On this basis Stephen Mendak et al. have created the device: the same “superlense” consisting of thin strips of silver, interleaved with semiconductor layers of silicon, gallium, indium and arsenicum. The difference in atomic structure of adjacent layers makes the material spontaneously curl up like a carpet, leaving a hole with a diameter of about 2 μm. If an object is placed inside the tube, the evanescent waves emerging on its surface and usually decaying at a distance of a couple of nanometers from this surface, are collected on the inner surface of the tube and start to move through its layers outwards, perpendicular to the circle. Primary image magnification occurs namely during this movement. This is the kind of process allowing to magnify nanoscale objects, usually invisible, up to the size where a standard optical lens can work with them.

In early 1980s, Gerd Binnig and Heinrich Rohrer, the employees of the Swiss IBM branch, invented a device allowing to examine single atoms of the matter. It used the quantum phenomenon of tunneling and the device was called “scanning tunneling microscope” (STM) [6].

They used the following idea: a very thin probe needle with a one-atom-thick tip is moved above the object surface at a distance of 1 nanometer. In accordance with the law of quantum mechanics, a tunneling effect occurs: electrons overcome the vacuum barrier between the object and the needle, and the electric current starts to flow in the “sample –needle” circuit. (Figure 6)

Figure 6: Evanescent waves.

The scheme of measurement of the state of a light wave spreading through the light guide. Decaying evanescent waves exist near the surface of the light guide (which is namely the near field area). You can turn a small number of photons from the near field into a measurement signal with the help of an NSOM probe [7].

The scheme of recording of the photons of the standing evanescent wave connected with the top prism surface with the use of a scanning tunneling photon microscope.

We consider that the cardiovascular, nervous and lymphatic systems can be light guides and that evanescent (decaying) waves are also formed around them, perpendicular to the external surface of vessels, capillaries, nerve roots, upon their exposure (of any section of the skin surface) to electromagnetic waves, i.e. the holistic organism enters the mode of a “scanning tunneling microscope,” therefore evanescent IR spectroscopy of the attenuated total reflection upon touching with an infrared fiber is a unique, non-traumatic technique which does not require any special skin preparation – it is “blood spectrobiopsy” reflecting the whole information picture of the organism at the atomic level.

It should also be considered that blood corpuscles, in particular erythrocytes shaped as concave oval plates, act as optical resonators enhancing the light passing through them in accordance with Ian Hooper’s experiment with transparent plates (Phys.Rev.Lett Magazine 97.053902.2006). The largest contribution to their investigation was made by Leo Esaki, the winner of the Nobel Prize in 1973, but they have not been observed in optics yet, according to I. Hooper, i.e. erythrocytes create resonant tunneling for the transmitted light [8].

The measurements of the spectra from the skin surface in vivo were performed with the use of a fiber sensor of the attenuated total internal reflection - an unjacketed AgClBr fiber with a diameter of 1 mm, plastically curved, with a radius of 5 mm. Infrared radiation from the Fourier’s interferometer of the Bruker Vector 22 spectrometer with the use of a ZnSe mirror-lens input with a focal length of 15 mm was introduced into the light guide and came out at the other end to a DTGS standard pyroelectric detector operating at room temperature. Figure 7

Figure 7: The scheme of registration of photons of a standing evanescent wave connected with the skin Surface (“blood spectrobiopsy”).

1 - Light source.

2 - Connecting head inserted into the opening of the metal box (connects the light source to the fiber optic cable).

3 - Fiber optic cable.

4 - The device for the mutual exchange of information of the whole organism with the biosphere.

5 - DTGS Pile Receiver.

6 - Bruker "Vector 22" spectrometer.

7 - Mirror-lens device for connection "Device for mutual information exchange of the whole organism with the biosphere" to the Fourier spectrometer "Vector 22".

8 - Computer.

9 - Contact switch.

10 - Contact leads from the non-abrasive fiber AgClBr.

11-MiniNanoMicroscope sensor.

12 - Surface of the skin of the whole organism.

In order to investigate the mechanism of transpiration system, the following experiments were conducted at the Fiber Optics Research Center of RAS, Moscow:

The results of this experiment (Figure 8) indicate good transmission of the light 480-3,400 μm on the dorsal surface of the right palm within the range of 1,600-3,400 cm-1 of the wave number; and a clear image of the spectrum was restored within the range of 500-1,600 cm-1 of the wave number after 10 minutes of exposure to amber light, as compared with the non-irradiated palm; that means the confirmation of the existence of a direct contact of blood with the environment and its accurate response to the stimulant (irradiation with amber light).

Figure 8: IR blood spectrobiopsy of the skin of the dorsal surface of the right palm after its exposure to amber light for 10 minutes and of the non-irradiated palm.

Figure 9 shows a clearly outlined sharp increase of the spectra of palmar and dorsal surfaces of the right hand after removal of two layers of epidermis with an adhesive tape followed by their exposure to amber light 480-3,400 μm for 10 minutes. Figure 10

Figure 9: Comparison of IR spectrobiopsy of blood from the palmar and dorsal surfaces of the skin of the right hand after removal of 2 layers of epidermis from them by adhesive tape followed by the exposure of the hand to amber light for 10 minutes.

Figure 10: Comparison of the IR spectrobiopsy of blood from the palmar surface skin of the hand after the removal of 2 layers of epidermis with the IR spectrobiopsy of blood from the palmar surface skin of the hand exposed to amber light for 10 minutes without the removal of 2 layers of epidermis.

This experiment demonstrates a pronounced increase in light transmission by the palmar surface after the removal of 2 layers of epidermis from it by adhesive tape, as compared with the spectrum without the removal of epidermis. Figure 11

Figure 11: Comparison of the IR spectrobiopsy of blood from the dorsal skin surface of the hand after the removal of 2 layers of epidermis with adhesive tape with the IR spectrobiopsy of blood from the dorsal skin surface of the hand exposed to amber light for10 minutes without the removal of 2 layers of epidermis.

This experiment repeated the results of the previous experiment, showing a pronounced increase of light transmission by the dorsal palm surface.

Correspondingly, our concept has been confirmed: the existence of a direct contact of blood with the outer world through transpiration system (excretion of liquid in the form of insensible vapor from the capillary tree of derma (true skin) - Figure 12, while epidermis does not participate in creation of blood IR spectrobiopsy.

Figure 12: Twelve skin structure.

It is known that the skin is a three-component tissue system consisting of epidermis, derma and hypodermis that are in the state of morpho-functional unity with each other and are constituted of multiple functionally structural elements.

1)dermal papillae;

2)skin furrow;

3)tactile rims;

4)excretory duct of perspiratory gland;

5)sensitive (tactile) corpuscle;

6)epidermis;

7)vessel and nerve trees under dermal papillae;

8) connective-tissue basis of skin;

9) tunica propria corii;

10) vascular tree;

11) subcutaneous tissue;

12) perspiratory gland.

Therefore, there is a reason to state that a spectral analysis of blood, rather than skin, is carried out from the surface of the skin of a living organism. Due to this reason, the expression “IR spectroscopy of the skin” should be considered incorrect.

The best way of early diagnostics is the research of various characteristics of the blood spectrum, since all vital activity data on the whole organism at the supramolecular level is deposited in blood. Therefore, the most efficient opportunity is the study of blood directly on the living body, when the blood is in a dynamic state. In order to solve this problem, we need the methods of non-invasive research, when the body does not experience any external influences contributing to the emergence of protective reactions of the living organism, involving, first of all, changes in the state of blood.

Conclusions

It has been established that the diagnostic zones and the zones of Zakharyin-Ged which are the projections of internal organs on the skin surface possess individuality and uniqueness of the characteristics of blood spectrobiopsy.

It has been established that blood is the only one from all internal organs and systems of a living organism that has a direct and reverse connection with the outer world through a system of insensible transpiration (the exudation of fluid in the form of insensible vapor from the blood through epidermis).

It has been established that blood instantly receives and deposits the data on all the processes of the holistic organism in the past, present and future simultaneously at the supramolecular level, i.е. blood is the main link of the “blood system” available for research and correction from birth to the last minutes of life.

It should be considered that the existing non-invasive medical diagnostic studies of the skin surface are a part of the data bank of the blood of the living organism. There is also a scientific need to create a classification of all non-invasive therapeutic and diagnostic methods of the skin surface in accordance with the international diseases classification.

It has been established that the IR spectroscopy of the attenuated total internal reflection upon touching of the skin surface with an infrared fiber is unique, non-traumatic, requiring no special preparation of the skin: this is “blood spectroscopy” of the diagnostic zones and zones of Zakharyin-Ged on the skin surface of a living organism in a normal state.

“Blood spectrobiopsy” can diagnose the pathology of organs and systems at the atomic level with high accuracy, detect early stages of diseases, intermediate states of developing pathologies and their arresting. This is a new progressive trend in medicine.