Specifications: alpha B Crystallin antibody [1D11C6E6]

Full Name

crystallin, alpha B

Product Description

Mouse monoclonal antibody [1D11C6E6] to CRYAB

Background

Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (sHSP also known as the HSP20) family. They act as molecular c

Synonyms

CTPP2 Antibody , HSPB5 Antibody , CRYA2 Antibody , CMD1II Antibody

Cellular Localization

Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles.

Host

Mouse

Clonality

Monoclonal

Clone Name

1D11C6E6

Target

CRYAB

Isotype

IgG2a

Immunogen

The immunogen corresponding to a region within amino acids 1 and 175 of CRYAB expressed in E. Coli.

Species Reactivity

Human

Storage Conditions: alpha B Crystallin antibody [1D11C6E6]

Storage Buffer

Ascitic fluid containing 0.03% sodium azide.

Storage Instruction

Store at 4℃, for long term storage, store at -20℃.

Notes

For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.