A brilliant scientist wakes up in a strange hotel room with a titanium briefcase shackled to his wrist and no idea how it got there. As he desperately tries to stay a step ahead of the international terrorists, CIA, and MI-6 agents chasing him across the globe, he realizes that he is the only person who can keep this mysterious briefcase from being delivered to Washington—and thwart what could be the deadliest terrorist attack in history.