Synthesis of 4-alkyl-6-amino-3,5-dicyano-2(1H)-pyridinethiones

Abstract

Condensation of aliphatic aldehydes with cyanothioacetamide has given 4-alkyl-6-amino-3,5-dicyano-2(1H)-pyridinethiones, which have also been synthesized by recyclization of 4-alkyl-2,6-diamino-4H-thiopyrans. Substituted 2-alkylthiopyridines and thieno[2,3-b]pyridines have been prepared from the pyridinethiones. 2,6-Diamino-4-isopropyl-3,5-dicyano-4H-thiopyran and 6-amino-4-isobutyl-2-methylthio-3,5-dicyanopyridine have been studied by x-ray crystallography.