The Our Lady of Fatima University, Quezon City Campus humbly started in 1997 in a building along Regalado Avenue in Quezon City [currently houses the Physical Therapy Center and the Fatima Eye Rehabilitation Center]. The noble mission of providing affordable but quality education in the cited side of the National Capital Region nurtured the dreams of 282 students in the light of its initial courses offered--- Bachelor of Science in Psychology, Bachelor of Science in Nursing , Bachelor of Science in Computer Science, Bachelor of Science in Hotel and Restaurant Management, Bachelor of Science in Tourism and majority of them belonged to the sections of Physical Therapy students. This population during its first operation was nurtured by seven teachers in the General education department and six teachers handling classes in Nursing, Computer Science,BS Physical Therapy ,BS HRM, and BS Tourism courses.

After the successful maiden year, the College of Arts and Sciences [CAS] made its mark as it was relocated to a bigger building at Hilltop Subdivision in Lagro, Quezon City. The former OLFU-QC CAS found a new home. And in the same year , new program was added to the roster namely Bachelor of Science in Biology From that time onwards, it has pitched in on the brink of continual improvement.

To date, the 5,444 square meter-land area has four multi-storey school buildings and an Atheletic Center. The expansion of the physical plant and facilities is in response to the development, demand, and dynamism of the Hilltop Campus through the years. Aside from continuous physical expansions, the student population has also increased through the years and has consistently posted annual growt.

Such is the testament to vouch for the trust and high regard accorded by its stakeholders, the people of the community and of the nearby areas to the ability and effectiveness of the OLFU educational system in adherence to its noble dictum that is to “improve man as man”.