Claws have an Attack requirement to wield them, commensurate with their tier. In addition to Attack, white claws also require level 10 Prayer and completion of the Wanted! quest, and chaotic claws require level 80 Dungeoneering.

Trivia

When attempting to wield claws while also wielding a crab claw in your glove slot, you will get a message saying "You need to remove your claw first." You can still wield claws while wielding a pirate's hook or the crabclaw hook.

Unlike other weapons, claws used to have the option to "wear" instead of "wield". This was unique, as only equippable non-weapon items have this option.

Claws used to exist in pairs, as a single item. They were separated into individual main hand and off-hand claws with the Evolution of Combat update. Before this, they were among the fastest two-handed weapons in the game.