Abstract

BIOCHEMICAL EFFECTS OF THE SPECTRA DOSES OF SPARFLOXACIN ON HEALTHY ALBINO RATS

Authors

*Ukpo Grace E, Adevokhai Gladys I, Ehianeta Teddy S, Ebuehi Albert OT

Description

The fluoroquinolones have become an increasingly popular class of antibiotics for use in a variety of infections. This study investigated the effect of the spectra doses of sparfloxacin on the clinical chemistry parameters of healthy albino rats. The rats were evenly distributed into four groups such that each group had similar mean weights. Group 1 (control group) was administered 2.0 ml of 0.9% normal saline solution throughout the experimental duration. Group 2 (sub therapeutic dose) was administered a loading dose of 0.7 mg/kg body weight by oral route on day 1 and 0.35 mg/kg body weight p.o on days 2 to 7 while Group 3 (therapeutic dose) was administered a loading dose of 0.35mg/kg body weight p.o on day 1 and 0.175 mg/kg body weight p.o on days 2 to 7. Group 4 (toxic dose) was administered a loading dose of 3.5 mg/kg body weight p.o on day 1 and 1.75 mg/kg body weight p.o on days 2 to 7. The elevated levels of alanine aminotransferase (ALT) in the sub-therapeutic group are suggestive of liver-related malfunction or injuries to the liver parenchyma.&nbsp; It can also be seen that sub-therapeutic doses of sparfloxacin has some inductive effects on the ALTs but inhibitory effects by the toxic doses. Since no elevated levels of aspartate aminotransferase (AST) were seen in the treated groups, this suggests sparfloxacin is not hepatotoxic. There was no statistical difference in the creatinine levels of the control as well as all the treated groups. Thus it can be concluded that the renal function is not affected as serum creatinine level is a more reliable indicator of renal function