None of the six FDR-significant CpGs identified as differentially methylated in relation to prenatal [PM.sub.10] in our discovery meta-analysis sample of 1,949 newborns could be replicated in the 688 newborns of the ALSPAC study (Table 2).

This book describes the work carried out by the Ethics and Law Committee of the Avon Longitudinal Study of Parents and Children (ALSPAC), a longitudinal birth cohort study in England in the 1990s, particularly how the core ethical principles were established by the committee at a time when there were no guidelines for ethical governance of such studies and health policies evolved as the study progressed and became more complex as the children grew up and the interest and understanding of the ethics of such studies developed and advanced in academia, politics, and other areas.

The study, which involved almost 9,000 mother and child pairs, used data from a world-leading birth cohort study, the Avon Longitudinal Study of Parents and Children (ALSPAC), also known as 'Children of the 90s'.

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