COX-1, H446K' is significantly more sensitive to downregulation by EP . Together these data suggest that distinctive ubiquitination of COX-1 and COX-2 may be responsible for their different sensitivity to EP -mediated degradation.

through complex formation with D1, EP1 signaling directs the D1 receptor through G(betagamma) to be coupled to AC7.

study provides firm evidence for the direct action of the PGE2-EP1 signaling on dopaminergic regulation in the midbrain. This EP1 action may explain the impulsive behaviors of Ptger1-/- mice due to a hyperdopaminergic state.

impaired adrenocorticotropic hormone response to bacterial endotoxin in mice deficient in this receptor

both the EP1 and the EP3 receptors play a role in fever induced by systemic inflammation but neither EP receptor is involved in the circadian rise in Tc or psychological stress-induced hyperthermia in mice.

EP(1) receptor is of major importance for colon cancer development and it could be a new target for a mechanism-based chemoprevention strategy against colon cancer development.

host EP1 and prostaglandin E receptor 3 receptors are involved in the control of local tumor growth, which translates into anorexia

the EP4 receptor mediates PGE2-induced renin secretion and that EP1, EP3, and EP4 receptors all contribute to enhanced PGE2-mediated salt and water excretion in the hyperprostaglandin E syndrome/antenatal Bartter syndrome model

Protein Überblick

The protein encoded by this gene is a member of the G protein-coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). Through a phosphatidylinositol-calcium second messenger system, G-Q proteins mediate this receptor's activity. Knockout studies in mice suggested a role of this receptor in mediating algesia and in regulation of blood pressure. Studies in mice also suggested that this gene may mediate adrenocorticotropic hormone response to bacterial endotoxin.