The patient will be treated by hybrid bone substitution with calcium-phosphate ceramic biomaterial and autologous bone marrow after necrosis exeresis

Primary Outcomes

Measure

The cure of ORN

time frame:
12 months

Secondary Outcomes

Measure

Evaluation of post operative pain at mandibular and bone marrow sampling site

time frame:

Quality of life

time frame:

Possibility of secondary dental prosthetic devices

time frame:

CT semiology description of the treated area

time frame:

Bone regeneration

time frame:

Number of hospital days

time frame:

Safety of hybrid bone substitution

time frame:

Eligibility Criteria

Male or female participants from 18 years up to 75 years old.

Inclusion Criteria:
- Adult patients (between 18 and 75 years) affiliated with an appropriate social
security system, diagnosed as suffering from symptomatic ORN, radiologically
confirmed, for which surgery is indicated
- Presence maximum of 2 outbreaks of ORN
- Oncological remission of the original tumor site for 1 year and for 3 years if the
ORN is in the contact or close to the initial tumoral site
- ECOG performance status 0, 1 or 2
- ORN symptomatic accessible to the conservation of at least one cortical mandibular
basilar
- Signed informed consent
Exclusion Criteria:
- Oncological treatment
- Haematologic background
- Current bone necrosis consecutive or concurrent to taking bisphosphonates
- Extension of ORN does not allow the retention of a mandibular rod (bicortical form)
- Presence of fracture complicating ORN
- Bisphosphonates during the last year
- Contraindications to the removal of iliac or sternum bone marrow
- Contraindication for general anesthesia