Tuesday, November 11, 2014

Fragile-X Syndrome (FXS): Spaced training improves long term memory

Prominent characteristics of the syndrome include an elongated face, large or protruding ears, and low muscle tone. Credit: Wikipedia

Research on mice with Fragile X syndrome (FXS) suggests that multiple, spaced training sessions can enhance learning and long term memory when longer, continuous sessions do not.

Christine Gall and colleagues at the University of California Irvine tested mice with FXS on their ability to remember objects and locations and found that multiple training sessions, with 60-minutes breaks, allowed them to perform as well as healthy mice.

FXS is the most common cause of inherited intellectual disability. Previous studies have shown that mice with this condition have a problem with synaptic signaling in the hippocampus, which affects their ability to create long term memories.