Category

Published on

31 Aug 2011

Abstract

See references below for related reading.

2.1 Elements of good engineering design
2.1.1 Whenever possible, use a general design that has already been tested
2.1.2 Whenever possible, take advantage of “biomimicry” – Nature has tried many designs!
2.1.3 Avoid “general purpose” design. Use multiple specific molecules to do specific tasks.
2.1.4 Control the order of molecular assembly to control the order of events
2.1.5 Therefore, perform the nano assembly in reverse order to the desired order of events

2.3 The challenge of drug/gene dosing to single cells
2.3.1 Precise targeting of drug delivery system while protecting non-targeted cells from exposure to the drug
2.3.2 How to minimize mis-targeting
2.3.3 How to deliver the right dose per cell
2.3.4 One possible solution – in situ manufacture of therapeutic genes

2.4 Bridging the gap between diagnostics and therapeutics
2.4.1 how conventional medicine is practiced in terms of diagnostics and therapeutics
2.4.2 the consequences of separating diagnostics and therapeutics
2.4.3 a new approach – "theragnostics" (or "theranostics")