@pkphi44, @Ginger and @Elpresidente22-
I will be reaching out to you all individually through our support email for further troubleshooting. Once a resolution is found, we will update this forum post accordingly. We appreciate your patience until then.

In trying to close some forum threads that had gone unanswered, I’m posting the outcome of this problem.

The problem was determined to be how we ask for permissions to access the USB reader. We changed how we request that permission from Android, and that seems to have resolved the issue of readers not being recognized on devices that have Knox enabled. This change was included in R2S 1.1.2 (911) and Sub Rosa 3.1.2 (911), both released January 23, 2017.