With jack on I can just connect input from usb to output from the card and hear the guitar. But without Jack it's silence again. . . . I can select the usb preamp in alsamixer but then I have a message saying that "this sound device does not have any capture control"!

Oh dear. It seems like nothing is simple with ALSA.

I'm assuming that you can record the guitar via JACK. Have you tried the same with your microphone yet?

Perhaps you will be able to figure out how to get JACK to talk to Skype, or perhaps a JACK or Skype user will pop in here to suggest an idea. I've never used either program.

I did not solve myeself a similar problem, whit normal vesion of puppy.
My workaround solution is:
install multy boot puppyes
try different ones
and I foun that puppy_racy_5.3 have the right drivers for my mic controller.
So when i need skipe conversation, i need to reboot.

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