Not really. Look at the Guardians of the Galaxy, other than Thanos they are not really connected to any of the other MCU character.

The thing is though that Thanos and none of the MCU villains have any ties with the Runaways. Runaways (if it gets made) should be a Disney animated project. It could work as a Disney animated project, just like Big Hero 6.

So how would a live action Runaways work within the context of the MCU?