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Ergo Proxy (エルゴプラクシー, Erugo Purakushī) is a science fiction suspense anime television series, produced by Manglobe, directed by Shukō Murase and written by Dai Satō. The anime originally aired from February 25 to August 12, 2006 on the WOWOW satellite network, lasting 23 episodes.

The series, which is heavily influenced by philosophy and Gnosticism, features a combination of 2D digital cel animation, 3D computer modeling, and digital special effects. After its release in Japan, the anime was licensed for a DVD release by Geneon Entertainment USA, with a subsequent broadcast on Fuse TV. The show was also distributed to Australian, British and Canadian anime markets. Since its release, Ergo Proxy has received mostly favorable reviews which praised its visuals and themes.

A manga spinoff called Centzon Hitchers and Undertaker (センツォン・ヒッチャーズ&アンダーテイカー, Sentson Hitchāzu & Andāteikā?) was written by Manglobe and illustrated by Yumiko Harao. The manga was serialized in Shogakukan's Monthly Sunday Gene-X from its March 2006 issue to the December 2006 issue. It was later released in two tankōbon format, the first in August 18, 2006, and the second on February 19, 2007.

In a future where the world has been ravaged by a nuclear apocalypse, there exists salvation in a domed city named "Romdo", where humans and their android servants, the AutoReiv, live in. Under the implementation of complete management control, it is a paradise where feelings are literally discarded, and the governing council dictates the way of life the citizens should live. But this utopian landscape is soon broken by a series of mystifying murders. Re-l Mayer, a female inspector from the Citizen Information Bureau, along with her autoreiv partner Iggy, are tasked to solve the murder cases. She is soon attacked by a creature drawn to her which is neither human nor android, and learns about the mysterious phenomena called "Awakening", an event which draws her further into the case...and to the world beyond the limits of Romdo.