With Rooney out of the starting lineup, veteran midfielder Ryan Giggs will make his 1,000th senior appearance. The move is certainly a puzzling one by Sir Alex Ferguson.

Tuesday's match, the second leg of the two clubs' UEFA Champions League Round of 16 clash, is absolutely pivotal, as a 0-0 draw would send United through to the quarterfinals and would eliminate Spanish powerhouse Madrid. Of course, a Madrid victory would send United home disappointed instead, and open up Ferguson to tons of criticism for this decision.

February's first leg ended in a 1-1 draw at the Bernabeu, as Cristiano Ronaldo leveled the match in the 30th minute, negating a 20th-minute goal from United's Danny Welbeck. Rooney assisted on Welbeck's early goal, and also recorded two shots in the draw.

The 27-year-old Rooney, who scored a goal in United's English Premier League win over Norwich City this past weekend, has made five Champions League starts in 2012-13, scoring just one goal on 14 shots and tallying three assists over that time.

Meanwhile, Giggs, 39, has appeared in four Champions League matches for United this season, coming on late in two as a substitute. The veteran has one assist but zero goals in those four appearances.