Abstract

The lack of normal B-cell differentiation in patients with acquired or congenital antibody deficiency may reflect abnormalities inherent in cells of B-lymphoid lineage or may involve abnormalities of regulatory (suppressor) cells. Circulating suppressor T cells, which interfere with IgM secretion in a plaque-forming-cell assay,
have been found in 60 per cent of these patients, but their role in the pathogenesis of the disease is unclear. … Read more