Long-term Effects of Lifestyle Intervention in Obesity and Genetic Influence

Summary

The purpose of the study is to determine the genetic influence on short-, middle- and
longterm effects of an inpatient lifestyle therapy program in overweight and obese children
and adolescents.

Description

In Germany, as in other countries, overweight and obesity affects a growing number of
children and adolescents. Obesity-related diseases such as arterial hypertension, disorders
of glucose and lipid metabolism and an increase in inflammation markers are associated with
higher morbidity and mortality in early life, therefore effective therapy concepts are
needed.

The aim of this study is to evaluate the effects of a 4-6 week inpatient obesity lifestyle
therapy program over 10 years and the genetic influence on the short-, middle- and longterm
outcome.

The lifestyle intervention consists of physical exercise, nutrition education and behaviour
therapy based on the criterions developed by the German Obesity Group (degree of weight
reduction, improvement of comorbidity and health behaviour, minimising of side effects).

Early obesity onset is a risk factor for specific comorbidities in adulthood, but whether this relationship is present in men and women with severe obesity is unknown. This study aimed to examine whet...

The prevalence of obesity in children has been shown to be plateauing or decreasing in some countries. However, the burden of severe obesity is often not assessed. Children with severe obesity may be ...

Despite great potential and extensive interest in developing biomolecule-based computing, the development of even basic molecular logic gates is still in its infancy. Digital comparator (DC) is the ba...

Medical and Biotech [MESH] Definitions

Fuzzy Logic

Approximate, quantitative reasoning that is concerned with the linguistic ambiguity which exists in natural or synthetic language. At its core are variables such as good, bad, and young as well as modifiers such as more, less, and very. These ordinary terms represent fuzzy sets in a particular problem. Fuzzy logic plays a key role in many medical expert systems.

Obesity, Abdominal

A condition of having excess fat in the abdomen. Abdominal obesity is typically defined as waist circumferences of 40 inches or more in men and 35 inches or more in women. Abdominal obesity raises the risk of developing disorders, such as diabetes, hypertension and METABOLIC SYNDROME X.

Obesity, Morbid

The condition of weighing two, three, or more times the ideal weight, so called because it is associated with many serious and life-threatening disorders. In the BODY MASS INDEX, morbid obesity is defined as having a BMI greater than 40.0 kg/m2.

Obesity, Metabolically Benign

A sub-PHENOTYPE of obese individuals who have a risk for CARDIOVASCULAR DISEASES between that of healthy individuals with normal weight and unhealthy individuals with obesity.

Pediatric Obesity

BODY MASS INDEX in children (ages 2-12) and in adolescents (ages 13-18) that is grossly above the recommended cut-off for a specific age and sex. For infants less than 2 years of age, obesity is determined based on standard weight-for-length percentile measures.

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