Compare Boniva vs. Prolia

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Boniva (ibandronate) is a first-choice treatment for osteoporosis and is available as a generic, but how you have to take it can be a hassle. It's also only approved for women, not men.

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2.9/ 5 average rating with 64 reviewsforBoniva

Prevents bone loss.

Prolia (Denosumab) is an effective and convenient treatment for osteoporosis if other options haven’t worked or aren’t appropriate for you. There’re risks of some rare side effects, so make sure you're following up with your doctor regularly.

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3.6/ 5 average rating with 15 reviewsforProlia

Upsides

Available in generic.

Available in pills that can be taken by mouth once a month.

Also available as a shot given into your vein every 3 months.

Prolia (Denosumab) is effective at preventing bone loss, making your bones stronger and lowering your chance of getting a fracture.

Only need to get an injection every 6 months, so you don’t have to remember to take something every day.

Downsides

You have to take Boniva (ibandronate) first thing in the morning with a full glass of water.

You have to remain upright for at least 60 minutes after you take the medicine, which can be a problem if you have mobility issues.

It is only approved to treat and prevent osteoporosis in women who have gone through menopause.

Approved for women only after they’ve reached menopause. Don’t use this if you’re pregnant or planning to become pregnant.

Can lower blood calcium levels. You might need to take calcium supplements to prevent this.