The story begins with a flashforward to the Tour de France, where Mikoto Shinozaki would become the first Japanese champion.

Time before this, and while feeling a deep crush on Yuki Fukazawa, Mikoto then decides to get into his high school cycling club as Fukuzawa's suggestion, even though he has never practiced any sport before. Ironically, the club's leader is Yousuke, Fukuzawa's older brother and a renowned road racer from his town. Yousuke's long time cycling partner and club's vice president Kouichi Terao sees in Shinozaki all the potential and courage necessary to become a road cycling legend.

Over drive is the story of how Mikoto Shinozaki becomes interested in cycling and all the ups and downs he must live to get his dream of becoming Tour de France's champion come true.

The series Over Drive has been licensed, it is not available in Manga Fox.