RESEARCH INTERESTS:
My research interests have been in different areas of retinal disease.

Since 1983, I have been a principal investigator in multicenter clinical trials regarding Retinopathy of Prematurity.(ROP). This is a retinal vascular disease that affects premature infants; I have led the team in Louisville in the CRYO-ROP study, the STOP-ROP study, the ETROP study , and currently the E-ROP study. These are multicenter trials evaluating different therapies for ROP.

I have been principle investigator in clinical trials evaluating treatment for infections of the eye (Endophthalmitis) and complex retinal detachment (Proliferative Vitreo-Retinopathy).

I was the Principle Investigator for the MARINA Study, which tested the use of Lucentis for Age –related Macular Degeneration, and am currently the Principle Investigator for the Complications of Age-related Macular Degeneration Treatment Trial, which is evaluating the use of Avastin and Lucentis to treat Macular Degeneration.

We have recently published or are in the process of publishing studies on macular holes, retained lens fragments, retinal detachment and epiretinal membranes.