It is the largest nation of the continent of Triagia, stretching across a third of the continent. It is also the most cosmopolitan nation on Midkemia and, on the surface, the most stable. The Empire is ruled by an Emperor or Empress and their relatives are called Truebloods. The Emperor or Empress is aided in their rule by Izmalis or Shadow Warriors. Previously, a large portion of the empire rebelled, forming the Keshian Confederacy, also known as Lesser Kesh, but it was ultimately defeated after a long war.

Ashunta - City near the Girdle of Kesh. A favoured route for slavers and renegades.

Balinor - An Elvish fort amidst the peaks of Quor, home to the Anoredhel, the sun-elves.

Caralien - northern-most port on Overn Deep.

Durbin - home of the Imperial Governor of Great Kesh, on the coast of the Bitter Sea. Durbin boasts arable farmland and a safe harbour, which for years made it a haven for pirates. It still has this reputation among many Midkemians.

Elarial - westernmost city of Great Kesh, located on the shore of the Endless Sea.

Farafra - port on the Dragon Sea.

Hansule - port on the Great Sea.

Hattaresh - city near the Spires of Light on the bank of the River Same.

Ishlana - city near the forest of Dark Haven.

Jalome - a southern port on Overn Deep.

Jonril - a city south of the Green Reaches, and original of the name for the modern city of Jonril, near the Green Heart.

Kampari - city located between the Spires of Light and Peaks of Tranquility.

Kesh (also called the Imperial City of Kesh) - capital city of Great Kesh and one of the most ancient cities in Midkemia.

Khattars - city in central Kesh.

Kimri - port on the eastern side of Overn Deep at the mouth of the river that leads to the Great Sea.

LiMeth - city near the Straits of Darkness.

Nar Ayab - northernmost city in central Kesh.

Queral - town located on the Great Sea.

Ranom - port on the Bitter Sea.

Shing Lai - trading city on the coast of the Dragon Sea at the western end of the Girdle of Kesh.