The 1925 race was taken out by three-year-old Manfred, who went on to win the VRC Derby and ran second to Windbag in the Melbourne Cup.

The class gallopers Heroic (21 wins from 51 races) and Amounis (33 wins from 78 races) were successful in 1926 and 1927.

Champion New Zealand-bred Nightmarch won in 1929 before Phar Lap took out the race in 1930 and 1931. Another dual winner of the race was Chatham in 1932 and 1934, as was Young Idea in 1936 and 1937.

The 1938 race was won by Ajax (36 wins from 46 races) in race record time. Outstanding New Zealand champion Beau Vite, a winner of 31 races, won in 1940 and 1941.

Due to restrictions on interstate travel, the race was only contested by local horses from 1942 to 1944.

In 1946, the Cox Plate was run in two divisions with the great mare Flight winning the stronger division. She became a dual winner following her victory a year earlier. Hydrogen became the seventh dual winner of the race with victories in 1952 and 1953. The great dual Caulfield Cup and Melbourne Cup winner Rising Fast won in 1954. Redcraze, a 32-race winner and New Zealand champion, took out the Plate in 1957 as a seven-year-old, ridden by George Moore. Noholme took nearly a second off the race record in a front-running display to win in 1959.

Tulloch, who is often compared to Phar Lap and Carbine, won the following year and again set a new race record. Tobin Bronze became a dual winner of the race with victories in 1966 and 1967. The 1969 Cox Plate was won by the New Zealand three-year-old colt Daryl's Joy, who went on to race successfully in the USA. The popular Goondiwindi grey, Gunsynd, was trainer Tommy Smith's third winner of the Cox Plate in 1972, and the New Zealand Derby winner Fury's Order staggered to victory on a bog track in 1975. Surround became the first three-year-old filly to win the race in 1976, when she defeated the VRC Derby winner Unaware.

Rubiton, the winner in 1987, went on to a successful stud career where he sired a future Cox Plate winner in Fields of Omagh. Better Loosen Up was 30 lengths from the lead, with 1000 metres to run, before winning the 1990 Plate in record time. He later became the first – and remains the only – Australian horse to win the Japan Cup. The eight-year-old Super Impose won in 1992 and defeated a top-class field which included Better Loosen Up, Let's Elope and favourite Naturalism, who lost his rider. Naturalism went on to run second in the Japan Cup. Australian Horse of the Year Octagonal defeated Mahogany in 1995, while Saintly gave Bart Cummings his second winner of the race in 1996 and Dane Ripper his third winner the following year. The 'People's Champion' Might and Power led throughout to win in 1998, setting the current record time of 2m 03.54s.

In a front-running display, Sunline won the 1999 Cox Plate and returned in 2000 to win again by seven lengths (equalling Dulcify's record winning margin), before West Australian champion Northerly defeated her in 2001 and 2002. In 2004, Savabeel became the first 3-year-old to win since Octagonal. In 2005, Makybe Diva triumphed and became one of the most popular horses in Australian racing history with an unprecedented third Melbourne Cup win 10 days later.

Fields of Omagh won his second Cox Plate in 2006, having already won in 2003, then finished second in 2004 and third behind Makybe Diva in 2005. In 2007, El Segundo won the Cox Plate, avenging his close defeat to Fields of Omagh the year before. In 2008, Maldivian led all the way to claim victory, while So You Think, at just his fifth career start, was an easy winner in 2009, giving Bart Cummings his fourth training victory in the race.

In 2013, Shamus Award recorded his first career win in the Cox Plate, a unique achievement for a WFA race of such high standing. He gained a start only due to the scratching of dominant favorite Atlantic Jewel.

The favourite in the Cox Plate[3] has an overall win rate of 41%. Favourites starting at less than $2.00 (Even money – 1/1) have a win rate of 70%. Phar Lap has the record of shortest favourite at $1.07 (1/14 on) in 1931.