Proteomics Peptides & KitsPeptide sets and pools, as well as assay standardization kits are available with stable isotope labeled or unlabeled proteotypic peptides for mass-spectrometry based proteomics such as MRM assays.

Chelate Peptides (DOTA)DOTA is linked to molecules that have affinity for various structures (e.g. somatostatin receptors in neuroendocrine tumors). The resulting compounds can be bound to radionuclided and are used with a number of radioisotopes in cancer therapy and diagnosis

Immunology Standards & ControlsStandards and controls for reproducible T-cell assays such as ELISPOT and multimer assays. We offer a large variety of positive and negative control peptide pools for antigen specific T cell stimulation as well as kit to produce TCR-engineered reference samples for performance control.

Antigen PeptidesAntigen peptides represent specific epitopes for stimulation of T cells in T cell assays such as ELISPOT. We offer the corresponding MHC multimer for each antigen peptide. Antigens from different pathogens are available as well as tumor associated antigens.

Cosmetic PeptidesCosmetic Peptides such as Lysine and Cysteine Peptide are used for DPRA (Direct Peptide Reactivity Assay) for Skin Sensitization Testing. The DPRA measures the reaction of a chemical with synthetic peptides containing Cysteine (Ac‑RFAACAA‑COOH) or Lysine (Ac‑RFAAKAA‑COOH) to assess its sensitization potency. For research use only!

Dimerizations

Peptide dimers or multimers have several advantages over their monomeric counterparts. For example, it is known that dimerization of GPCR ligands can result in a significant increase in affinity. Another example are MAPs (multiple antigenic peptides), where formation of multimers leads to increased immune response (see Linker / Spacer / PEGylationsfor details).

The chemistry used for peptide dimerization often takes advantage of the chemoselective reactions between unprotected peptides. Examples are the formation of the following bonds: Cys-maleimide thioethers, disulfides or triazoles (click chemistry). See the table below for their respective structures. In addition to the depicted chemoselective dimerization methods below, it is also common to dimerize protected peptide fragments (e.g. for the synthesis of dimers connected by amides).