From Basicsto Disease

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Janus kinases (Jaks), signal transducers and activators of transcription (Stats) form a unique, fast track for signal transduction from cell surface receptors to target genes. Jak-Stat signalling contributes in many ways to the integrity of organisms and disturbance of this signalling avenue causes disease in mammalian organisms, including humans.

The present initiative SFB-JakStat is a special research programme granted by the Austrian Science Fund FWF.

It pools existing resources by creating a veritable JakStat-platform that is amongst the largest in Europe or North America. This state-of-the-art scientific network consists of nine basic research-oriented groups from three different universities, namely the University of Vienna, the Medical University of Vienna, the Veterinary University of Vienna includingits research center Biomodels Austria, the research Institute of Molecular Pathology and the Ludwig Boltzmann Institute for Cancer Research.

SFB-JakStat presents combined efforts to address the role of Jaks and/or Stats in two important categories of disease:

infection/inflammation and cancer. An intimate inter-relationship between both processes is emerging from recent literature. Hence, particular efforts will be made - and present a main raison d'etre for the consortium - to understand Jaks and Stats signals and mechanisms linking infection, inflammation and cancer.