INTEGRA® Template
is indicated for the post-excisional treatment
of life threatening full-thickness or deep
partial-thickness thermal injuries where sufficient
autograft is not available at the time of
excision or not desirable due to the physiological
condition of the patient.

INTEGRA® Template
is also indicated for the repair of scar contractures
when other therapies have failed, or when
donor sites for repair are not sufficient
or desirable due to the physiological condition
of the patient.

INTEGRA® Template
is a bi-layer skin replacement system available
in meshed and non-meshed configurations and
comprised of a dermal regeneration layer and
a temporary epidermal layer. Within the dermal
regeneration layer the collagen-glycosaminoglycan
(GAG) matrix provides an environment for cellular
infiltration, native collagen deposition,
and neovascularization. This biodegradeable
template induces the organized regeneration
of dermal tissue by the body. The result,
"Neodermis", is functionally normal
dermis produced without skin appendages.

The Stern study demonstrated
an intact dermis was achieved with regrowth
of apparently normal reticular and papillary
dermis. In addition, no scar formation appeared
at any time during the course of healing in
any of the biopsies of the patients examined.

In the first surgical procedure
the wound is excised to viable tissue and
INTEGRA® Template is applied. Over the next
2-3 weeks, the dermal layer is regenerated
while simultaneously degrading the collagen-GAG
matrix. The biodegradable template induces
organized regeneration of normal dermal tissue
("Neodermis") by the body. At approximately
21 days, in a second surgical procedure following
dermal regeneration, the silicone layer is
removed and a thin epidermal autograft 0.004-0.006
inches (0.1016 - 0.1524 millimeters) is applied.
The thin donor site will heal faster and can
be harvested more frequently than conventional
donor sites which are typically 2-3 times
deeper. Engraftment and confluence of the
epidermal graft complete the process in about
30 days from the first procedure.

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