RB Jacobs inactive vs. Bills; NG Sopoaga returns

In a bit of a surprise, 49ers running back Brandon Jacobs, who declared himself healthy this week after suffering a knee injury in the preseason, is inactive for today’s game against the Bills.

The 49ers will suit up three running backs in Frank Gore, Kendall Hunter and Anthony Dixon, who, unlike Jacobs, provides versatility with his ability to play special teams. The 49ers had listed Jacobs as questionable. It will be interesting to see if Jacobs is back in action next week when the 49ers host the Giants, the team Jacobs spent the first seven seasons of his career with.

Meanwhile, nose tackle Isaac Sopoaga (ankle, knee), who missed last week’s game against the Jets, and cornerback Carlos Rogers (ankle) are active. Both were listed as questionable for today’s game.