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Modification of fatty acid composition of polar and neutral lipids of blood and liver in rat in conditions of prolonged high-fat diet

1. Vladivostok Branch of the Far Eastern Center of Physiology and Pathology of Respiration of SB RAMN - Institute of Medical Climatology and Rehabilitative Treatment2. Institute of marine biology of name A.V. Zhirmunskogo of the Far East department of the Russian Academy of sciences; Far-East Federal University

Abstract: Studied the composition of fatty acids of polar and neutral lipids of plasma, erythrocytes and liver Wistar rats under prolonged high-fat diet. It was established that during long-term (90-180 days) in rats high-fat load is blocking the cells ligand-retseptor active capture polyunsaturated fatty acids (PUFAs) in the low-density lipoprotein (LDL). This is confirmed by the accumulation of blood in LDL cholesterol and lipid fractions, esterified n-3 and n-6 PUFA (triacylglycerides, sterols esters, phospholipids), while the deficit these same fatty acids in the lipids of erythrocytes. In the liver under the influence of prolonged high-fat diet increased pool monoenic (18:1 n-9) and polyunsaturated (20:5 n-3, 20:3 n-6, 22:5 n-3) fatty acids. These data suggest that prolonged exposure of rats high-fat diet contributes to compensatory de novo synthesis of fatty acids in the liver. However, due to violations of the receptor active transport of fatty acids synthesized in the liver fatty acids are not captured by cells of the peripheral organs. Identified data allow us to expand the understanding of the role of nutritional factors in the physiology and pathophysiology of the cell, modulation of lipid metabolism.