NFL Media's Alex Flanagan reported during the tilt that the Browns fear Hoyer tore knee ligaments, and NFL Media's Albert Breer reported Friday morning that Hoyer is believed to have a torn ACL, per a source briefed on his injury.

Weeden replaced Hoyer immediately and was booed after a few throws. Wide receiver Davone Bess was the team's emergency quarterback had Weeden gotten hurt because Jason Campbell was inactive.

The injury came after Hoyer escaped pressure and rushed for a first down. Bills linebacker Kiko Alonso tackled Hoyer after the quarterback appeared to start going into a slide. Hoyer's legs bent underneath him awkwardly. There will be questions whether Alonso committed unnecessary roughness, but it was a bang-bang play.

Hoyer and the resurgent Browns have been a great story the last couple of weeks. Despite the win, this puts a big damper on things.