A power struggle between former President José Mário Vaz and Guinea-Bissau’s ruling Party for the Independence for Guinea and Cape Verde plunged the country into a series of political and institutional crises following the dismissal of Prime Minister Domingos Simões Pereira in August 2015. From the beginning, ECOWAS took an active role in resolving the impasse, embarking on several rounds of mediation missions led by former and current regional heads of state, as well as a delegation of regional ministers. The culmination of these efforts resulted in the October 2016 Conakry Accord, a 10-point roadmap for resolution designed to foster political stability and cooperation among the country’s governing members. ECOWAS’s sustained engagement in Guinea-Bissau provides a blueprint for future political and institutional crises in the region.