Doyle Muscare was originally, found near the bottom of House Crimson, sitting near a barrel fire with Kim Soltoon, part of Tic Tonic's gang. When spoken to, he will mention that Vinny Ramón and Lin Rhodes were part of the same gang, before joining the Infinity Franchise, as well as saying "They'll be back, it's just a phase." He also notes that "Everyone's been losing too much turf. The Franchise doesn't know how to play"

After Alex takes the bag containing a Mystery Jerky and three Cigarettes in the area with Twisty in it, Doyle will now be found right of the "Olathe Public School" sign in House Crimson, having put on an Infinity Jersey taken from a nearby corpse pile and killing Kim Soltoon.

In battle, when Doyle's health drops below 60% he will say "I'll make mincemeat out of you!" and be inflicted with Rage, finally, upon dying he will ominously say "They'll kill you for me."