Precious is the tragic and triumphant story of an obese and illiterate teenager pregnant for the second time by her rapist father and beaten down physically and mentally by her monstrous mother. When Precious gets the opportunity to attend a special high school program, a whole new world opens up. "When I first saw the movie Precious, I was so deeply moved, I immediately called up the director, Lee Daniels, and told him that it just split me wide open," Oprah says.

Comedian Mo'Nique takes a brutally dramatic turn as Precious' abusive mother, Mary Jones. Oprah says she had to call Mo'Nique after she saw her performance. "I remember exactly what you said when you called me," Mo'Nique says. "You said, 'Hey, girl, what you wearing to the Oscars®?'"