SAN FRANCISCO, CA (The Spread) – Oddsmakers currently favor the 49ers for tonight’s big tilt against the Lions at 8:20PM ET.

DETROIT:The Lions had to survive their Week 1 tilt with the Rams. Matthew Stafford led Detroit to a 27-23 come-from-behind victory but threw three interceptions in the game, including one that was returned for a touchdown by Cortland Finnegan. Calvin Johnson racked up six catches for 111 yards but was held out of the end zone, while Kevin Smith rushed 13 times for 62 yards and a score. Despite the victory, the Lions failed to cover as a 9-point home favorite.

SAN FRANCISCO:The 49ers shocked the masses in Green Bay by beating the Packers 30-22 as a 6-point underdog. Alex Smith completed 20-of-26 passes for 211 yards and two touchdowns, while Frank Gore rushed 16 times for 112 yards. Michael Crabtree caught seven passes for 76 yards and Randy Moss caught all four of his targets for 47 yards and a score. The 52 points soared over the posted total of 46.5 points.

ODDS:The 49ers opened as 7-point favorites but despite 73% of the NFL backing San Francisco, the spread dropped down to 6.5. The total for this game is 46.5.

TRENDS:The under is 6-0 in the last six meetings between these two teams in San Francisco and 8-0 in the last eight meetings overall. The Lions are also 1-3-2 against the spread in their last six games in San Francisco and 0-3-1 ATS in the last four meetings overall. The underdog is 3-1-2 against the number in the last six meetings between these two teams and the road squad is 3-1-2 ATS in the last six meetings.

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