Some parts of the territory of Vinnitsa region were used to create Khmelnitsky oblast on September 22, 1937. Until January 4, 1954, it was called Kamenets Podolskiy region. Until 1941, the administrative center of the region was the city of Kamenets Podolskiy.

The so-called sword of Karabchiev, one of the most beautiful ancient Russian swords, was found near Kamenets Podolskiy, it dates back to the 10th - the first half of the 11th century.