John and Mark continue their conversation on the latest science to support effective and sustainable lifestyle changes to prevent or reverse obesity, pre-diabetes, diabetes and metabolic syndrome. They will explore the connection between common environmental inputs, inflammation, and insulin resistance. So epidemic has this disruptive metabolic landscape become for all ages that it is known to be strongly associated with all chronic complex diseases like cardiovascular disease, cancer, Alzheimer’s, and shorter life expectancy. It is also, for the most part, preventable and treatable with lifestyle interventions.