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CNS Safety Pharmacology

In safety pharmacology studies, according to the ICH S7A guidelines, effects of the test substance on the central nervous system should be assessed appropriately. Motor activity, behavioral changes, coordination, sensory/motor reflex responses and body temperature should be evaluated.

Description

For in vivo studies, wireless telemetry is the preferred technique, as it allows data collection from unrestrained animals, which is particularly important for behavioral assessments.

On rodents, concurrently with neuro-behavioural assessment, such as Irwin test or Functional Observational Battery, the wireless technology of the rodentPACK allows the simultaneous evaluation of brain activity (EEG recording) and motor activity (3-axis acceleration & synchronized video). Cognitive function can also be assessed concurrently with EMG recordings.

Telemetry as also been shown to be useful to evaluate drug dependence. With emkaPACK4G non-invasive telemetry, continuous monitoring of body temperature, locomotor activity, heart rate, blood pressure and respiratory rate, in conjunction with the more classic measures of food intake and changes in body weight, can be performed on large animals, to assess drug dependence.