Amarillo has a population of around 196571, of which 96237 (48%) are male and 100334 (51%) are female. The average age of the inhabitants of Amarillo is 35.44, meaning that the average person is below the national median age of 37. For every male, there are approximately 1.04 females, meaning that the population is relatively evenly distributed between males and female(s).

Of Amarillo's 196571 residents, around 189804 (96.60%) identify as having a single race. The majority of the population is white, which consists of 83.20% of the population. Of the remaining population, 12601 are black/African Americans (6.40%), 1101 are native Americans (0.60%), 7201 are asians (3.70%), 334 are pacific islanders (0.20%), 5101 are other (2.60%).

The median income of households in Amarillo is $47735.00, meaning that most of the households are above the poverty threshold for families of three. Of the total population, 6.90% of households reported an annual income of less than $10,000.