Kappa Light Chain Antibody (L1C1) [PE] Summary

Immunogen

B lymphoma cells

Localization

Cell Surface, Cytoplasmic and Secreted

Marker

B-Cell Marker

Specificity

This MAb is specific to kappa light chain of immunoglobulin and shows no cross-reaction with lambda light chain or any of the five heavy chains. In mammals, the two light chains in an antibody are always identical, with only one type of light chain, kappa or lambda. The ratio of kappa to lambda is 70:30. However, with the occurrence of multiple myeloma or other B-cell malignancies this ratio is disturbed. Antibody to the kappa light chain is reportedly useful in the identification of leukemias, plasmacytomas, and certain non-Hodgkin's lymphomas. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is malignant.

Isotype

IgG1 Kappa

Clonality

Monoclonal

Host

Mouse

Gene

IGKC

Purity

Protein G purified

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