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[Publication-type] Case Reports; Journal Article

[Publication-country] United States

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title]Angiolymphoid hyperplasia with eosinophilia on the palm.

Angiolymphoid hyperplasia with eosinophilia (ALHE) is an uncommon dermal angioproliferating tumor, characterized by red to brown papules or nodules on the head and neck, though also occurring in the mouth, trunk, extremities and inguinal area.

The palm is a very unusual site for ALHE, and there have been very few cases reported globally thus far.

ALHE can be pruritic and painful and histopathologic findings show vascular proliferation with infiltration of eosinophils and lymphocytes in the dermis.

We report a case of ALHE occurring at an unusual site, the right palm, in a 62-year-old man, who had suffered from a solitary pinkish-colored, central depressed round hyperkeratotic plaque on his palm for 4 years.

On the basis of clinical and histopathologic data, a diagnosis ofALHE was made.

To our knowledge, this is the first report of ALHE on the palm in Korean dermatologic literature.

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[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title]Angiolymphoid hyperplasia with eosinophilia developing on an antecedent welding burn: a case report.

Angiolymphoid hyperplasia with eosinophilia (ALHE) describes a group of benign anomalous vascular hyperplasias which consist of epithelioid-like endothelial cells attached to dilated blood vessels, and infiltration of inflammatory cells, predominantly lymphocytes and some eosinophils.

Here, we describe a healthy 34-year-old man, who had 10 well-defined, non-tender, red-to-brownish papules and subcutaneous nodules of 0.3-1.0 cm in diameter on his left forearm.

The histopathologic diagnosis of the lesions was ALHE.

Because the new lesions developed progressively and malignancy could not be excluded, the patient underwent a wide elliptical excision and received a split-thickness skin graft from his left thigh.

The forearm is an unusual site for ALHE; the antecedent burn was the key trigger for ALHE onset in this case.

[Title]Angiolymphoid hyperplasia with eosinophilia: atypical appearance in an older patient.

On the basis of these features, the patient was diagnosed as having angiolymphoid hyperplasia with eosinophilia (ALHE).

We present the case because of its rarity in older people, atypical clinical appearance; and stress the consideration of ALHE in the differential diagnosis of chronic non-healing superficial ulcers confined to face and neck.

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[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title]Angiolymphoid hyperplasia with eosinophilia: successful treatment with the Nd:YAG laser.

Angiolymphoid hyperplasia with eosinophilia (ALHE) is an uncommon idiopathic proliferation of blood vessels that manifests in adults as isolated or grouped papules, plaques, or nodules in the skin of the head and neck.

We describe the case of a 31-year-old woman with a 3-year history of persistent ALHE, located on the tragus of her right ear, with no sign of spontaneous regression over a period of 3-6 months and refractory to intralesional corticosteroids.

We report the successful use of the Nd:YAG laser for this condition, which offered excellent symptomatic and cosmetic results and suggests the consideration of this modality in the treatment of ALHE.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

Angiolymphoid hyperplasia with eosinophilia (ALHE) is a benign, uncommon idiopathic condition, characterized by cutaneous papules or nodules, whose etiopathogenesis is still unclear.

It has been considered an angioproliferating lesion (epithelioid hemangioma) since histologically it is marked by a proliferation of blood vessels, accompanied by an inflammatory infiltrate, consisting mainly of lymphocytes and eosinophils.

We present a case of ALHE assessed immunohistochemically for D2-40-a new marker for lymphatic endothelial cells.

The ALHE specimen showed increased number of lymphatic vessels when stained for D2-40, whereas the endothelial cells lining blood vessels were negative.

The specificity of D2-40 for lymphatic vessels was further substantiated by studying Factor VIII-related antigen expression in consecutive sections of both ALHE and the control specimen.

We therefore assume that apart from the lymphocytic infiltrate in the lesion, the recognized lymphoid component in ALHE is due to lymphatic vessel proliferation as well.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] [Epithelioid hemangioma of the foot].

Epithelioid hemangioma (angiolymphoid hyperplasia with eosinophilia, EH/ALHE) is a rare benign angioproliferative lesion which typically occurs in the region of the head and neck.

A case of multiple occurence of EH/ALHE in the skin of the toes and metatarsal bone with osteolysis is reported.

The key diagnostic features of EH/ALHE are vascular channels lined with epithelioid endothelial cells, surrounding layer of myopericytes, absence of atypia and mitotic activity and characteristic inflammation.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

BACKGROUND: Angiolymphoid hyperplasia with eosinophilia (ALHE) is a benign vascular proliferation characterized by dermal or subcutaneous nodules or both, primarily in the head and neck.

We report the successful treatment of ALHE without scarring using a 595 nm ultralong pulsed dye laser, which applies a unique combination of longer wavelengths, a longer pulse duration, and a higher fluence.

OBJECTIVE: To report the use of the 595 nm pulsed dye laser in the treatment of ALHE and to detail the particular aspects of this laser that make it uniquely qualified to treat this entity.

RESULTS AND CONCLUSION: This laser may be used as an effective treatment for ALHE and has advantages over alternative treatments and older lasers.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Spontaneous regression of a rare tumour in a child: angiolymphoid hyperplasia with eosinophilia of the hand: case report and review of the literature.

Angiolymphoid hyperplasia with eosinophilia (ALHE) is an uncommon benign, idiopathic vasculoproliferative condition manifested by multiple or solitary subcutaneous nodules, usually in the head and neck region of young adults.

We report an 11-year-old girl with histologically confirmed ALHE on the dorsum of her left hand, which underwent complete spontaneous regression within 10 weeks.

Angiolymphoid hyperplasia is a benign disease and it is important to recognise this condition so that early superficial lesions can be observed for 3-6 months pending spontaneous regression.

[Number-of-references] 30

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title]Angiolymphoid hyperplasia with eosinophilia that was possibly induced by vaccination in a child.

Angiolymphoid hyperplasia with eosinophilia (ALHE) is a rare benign vasoproliferative disease of an unknown cause involving the skin or subcutaneous tissue of the head and neck, and particularly around the ear.

We experienced a case of ALHE in a 2-year-old Korean boy who had a firm, pruritic, skin-colored, subcutaneous nodule on his right upper arm.

The histopathological findings were compatible with ALHE and they showed prominent vascular changes with epitheloid or histiocytoid endothelial cells surrounded by inflammatory cells, including a large proportion of eosinophils.

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[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title]Angiolymphoid hyperplasia with eosinophilia developing in a patient with history of peripheral T-cell lymphoma: evidence for multicentric T-cell lymphoproliferative process.

BACKGROUND: Angiolymphoid hyperplasia with eosinophilia (ALHE) is a vasocentric process characterized by infiltrates of lymphocytes and eosinophils, usually affecting the muscular arteries of the head and neck.

REPORT: We present a 61-year-old African American male with a twenty year history of superficial skin patches involving the head and neck region.

Three months later the patient underwent a biopsy of a left temporal nodule that was diagnosed as ALHE.

CONCLUSION: ALHE with molecular evidence of monoclonality is extremely unusual, as is the association with nodal peripheral T-cell nodal lymphoma.

The findings of this case support our hypothesis that ALHE might be an early form of T-cell lymphoma.

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[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title]Angiolymphoid hyperplasia with eosinophilia (epithelioid hemangioma) of the lung: a clinicopathologic and immunohistochemical study of two cases.

Two cases of primary angiolymphoid hyperplasia with eosinophilia (epithelioid hemangioma) (ALHE/EH) of the lung are described.

Wedge resections were performed in both cases, and both lesions shared similar histopathologic changes, mainly the presence of a tumor mass with a marked presence of eosinophils in the background, lymphoid hyperplasia, and marked proliferations of small-caliber vessels.

Both cases highlight the ubiquitous distribution of ALHE/EH and underscore the importance of keeping these lesions in the differential diagnosis of vascular and lymphoid lesions of the lung.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title]Angiolymphoid hyperplasia with eosinophilia: good response to photodynamic therapy.

Angiolymphoid hyperplasia with eosinophilia (ALHE) is an uncommon benign vascular disease of unknown pathogenesis, that occurs as solitary or multiple nodules or papules.

We report a case of ALHE treated with aminolaevulinic acid photodynamic therapy (ALA-PDT).

We believe that PDT could be an alternative therapeutic approach for ALHE or could be used as a neoadjuvant treatment to reduce lesion size especially where size or site of lesions limits the efficacy or acceptability of other treatments.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Severe atherosclerosis of the aorta and development of peripheral T-cell lymphoma in an adolescent with angiolymphoid hyperplasia with eosinophilia.

We report an adolescent girl with a history of angiolymphoid hyperplasia with eosinophilia (ALHE) diagnosed at the age of 10 years.

Atherosclerotic occlusive disease of the abdominal aorta and its major branches was observed at the age of 17 years, necessitating vascular surgical intervention 1 year later because of disease progression.

Neither systemic atherosclerosis nor T-cell lymphoma has been reported in association with ALHE.

It is suggested that a highly stimulated dysfunctional immune response may play a key role in persistent inflammatory disease and premature development of atherosclerosis as well as malignant transformation of T cells.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

The mechanisms leading to the development of eosinophilia were investigated in 65 patients with immunodermatological disorders, including the role of eosinophilotactic cytokines and the possible involvement of human T-cell leukemia virus, HTLV.

HTLV-1 gag proviral sequences were revealed in two cases of lymphoproliferative disorders such as angiolymphoid hyperplasia with eosinophilia (ALHE) and CD4+ cutaneous lymphoma, respectively.

Neither of the four cytokines, however proved to be responsible alone or together for the induction of eosinophilia.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title]Angiolymphoid hyperplasia with follicular mucinosis.

Follicular mucinosis occurring along with angiolymphoid hyperplasia with eosinophils (ALHE) has been described in a 54-year-old female.

Histopathological examination showed prominent blood vessels in the dermis lined by plump histiocytoid endothelial cells that were surrounded by a dense lymphoid infiltrate with numerous eosinophils; these findings are typical of angiolymphoid hyperplasia with eosinophils.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

BACKGROUND: Angiolymphoid hyperplasia with eosinophilia (ALHE) is an uncommon vascular inflammatory lesion usually involving the dermis or subcutaneous tissue of the head-neck region of middle-aged women.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title]Angiolymphoid hyperplasia with eosinophilia on the tongue.

Angiolymphoid hyperplasia with eosinophilia (AHE) is a benign reactive vascular lesion characterized by a proliferation of small to medium sized vascular structures lined by epithelioid endothelial cells.

Histopathological findings confirmed a diagnosis of angiolymphoid hyperplasia with eosinophilia.

[Publication-type] Case Reports; Journal Article

[Publication-country] United States

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Giant angiolymphoid hyperplasia with eosinophilia on the chest.

Angiolymphoid hyperplasia with eosinophilia is a rare vascular proliferation characterized by single or multiple purplish, brownish papules and subcutaneous nodules, sometimes associated with pain or pruritus.

Approximately 85% of the lesions occur in the skin of the head and neck; most of them are around the ear or on the forehead or scalp.

Whether angiolymphoid hyperplasia with eosinophilia represents a benign neoplasm or an unusual reaction to varied stimuli, including trauma, the etiology remains unclear.

Histopathologically, the lesions consist of a proliferation of blood vessels of variable size lined by large epithelioid endothelial cells and a variable inflammatory infiltrate of lymphocytes and eosinophils, sometimes with lymphoid follicle formation.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

Kimura disease and angiolymphoid hyperplasia with eosinophilia are rare disease entities that can manifest as subcutaneous nodules, plaques, or papules of the head and neck, and less commonly the orbit and ocular adnexa.

This clinicopathologic report of a patient who presented with a right lower eyelid mass with pathologic features consistent with Kimura disease and a left conjunctival mass with features consistent with angiolymphoid hyperplasia with eosinophilia poses a challenge to the notion that these are distinct conditions.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title]Kimura's disease and angiolymphoid hyperplasia with eosinophilia: two disease entities in the same patient: case report and review of the literature.

BACKGROUND: Much controversy has existed with regard to the relationship between Kimura's disease and angiolymphoid hyperplasia with eosinophilia.

They were initially thought to represent the same disease spectrum, but it has now been widely accepted that they are two separate disease entities.

To our knowledge, there have been no reports to date describing a case of both Kimura's disease and angiolymphoid hyperplasia with eosinophilia coexisting in the same patient.

METHODS: We describe a patient presenting initially with a right postauricular subcutaneous swelling and subsequently developing multiple erythematous facial papules and nodules.

RESULTS: Clinical features of the right postauricular subcutaneous swelling and multiple erythematous facial papules/nodules suggest Kimura's disease in the former and angiolymphoid hyperplasia with eosinophilia in the latter.

Histopathological examinations of these lesions helped to confirm the diagnosis of Kimura's disease and angiolymphoid hyperplasia with eosinophilia, respectively.

CONCLUSIONS: Kimura's disease and angiolymphoid hyperplasia with eosinophilia can coexist in the same patient.

Coexistence of the two types of lesions in one patient may also be considered evidence that Kimura's disease and angiolymphoid hyperplasia with eosinophilia form a spectrum in one disease.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

Angiolymphoid hyperplasia with eosinophilia is an uncommon condition that usually presents in early to middle-aged adults as multiple red nodules or plaques, most commonly on the head and neck.

The histopathological hallmark is the presence of blood vessels with plump epithelioid endothelial cells.

The occurrence of numerous giant cells in the stroma of angiolymphoid hyperplasia with eosinophilia is extremely unusual and such a finding in association with diffuse granulomatous/fibrous reaction has not been reported.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title]Cutaneous epithelioid angiomatous nodule: different views or interpretations in the analysis of ten new cases.

Cutaneous epithelioid angiomatous nodule (CEAN) was described in 2004, but there is no agreement as to whether this is a distinct entity or a type of either epithelioid hemangioma or angiolymphoid hyperplasia with eosinophilia.

AIMS: To study the immunohistochemical expression of HHV8 in Kaposi's lesions and in other vascular lesions and to determine the utility of this technique in differentiating between Kaposi's disease (KD) and other vascular lesions.

RESULTS: Sixteen cases of KD showed positive staining, whereas all cases of hemangioma, angiolymphoid hyperplasia with eosinophilia and angiosarcoma were negative for this antigen CONCLUSION: Immunohistochemical detection of the human herpesvirus-8 latent nuclear antigen-1 is a useful for differentiating between KD and other vascular lesions.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

It is a rare clinicopathologic entity with fewer than 20 reported cases, most of which represent localized disease with no recurrence or systemic symptoms at follow-up of up to 2 years.

As the histology may resemble angiolymphoid hyperplasia with eosinophilia or Kimura disease, whether JTA is a discrete localized disease or a manifestation of these systemic conditions has been debated.

We present a case of a 36-year-old Jamaican woman with a painful forehead nodule that showed histologic features of JTA, including intimal hyperplasia, lymphoeosinophilic inflammation of the vessel wall, and disruption of the internal elastic lamina; distinctive signet ringlike cytomorphologic alterations of the endothelial cells were noted as well.

The lesion also showed extensive subcutaneous lymphoeosinophilic infiltrates and neovascularization with extension into the underlying muscle consistent with angiolymphoid hyperplasia with eosinophilia or Kimura disease.

As the connection between JTA and angiolymphoid hyperplasia with eosinophilia and Kimura disease is currently debated and most reported cases of JTA have had only brief follow-up, the long-term sequelae of JTA are not known and careful patient monitoring may be necessary.

[Title] Building Native Hawaiian capacity in cancer research and programming. A legacy of 'Imi Hale.

Between 2000 and 2005, 'Imi Hale involved more than 8000 Native Hawaiians in education, training, and primary and secondary prevention activities; developed 24 culturally tailored educational products (brochures, curricula, and self-help kits); secured $1.1 million in additional program and research funds; trained 98 indigenous researchers, 79 of whom worked on research projects; and engaged more than 3000 other Native Hawaiians as research participants and advisors.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title]Epithelioid hemangioma of the colon: a case report.

CONTEXT: Epithelioid hemangioma or angiolymphoid hyperplasia with eosinophilia is an uncommon benign vascular neoplasm that is usually located on the face or neck.

The aim here was to present a case of primary epithelioid hemangioma of the sigmoid colon with confirmation by immunohistochemical examination.

A biopsy collected during the examination suggested a diagnosis of neoplasia of vascular origin.

After surgical resection, histopathological examination of the resected specimen confirmed the diagnosis of epithelioid hemangioma of the colon, which was backed up by the immunohistochemical panel (factor VIII, Ki-67, CD-34).

Despite the rarity of neoplasia of vascular origin, this possibility should be considered in the differential diagnosis for colorectal tumors.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

We prefer the designation "papular angiolymphoid hyperplasia" to APACHE as it encompasses all the childhood and adult cases involving acral and nonacral sites and highlights the histological and sometimes clinical similarities this entity shares with angiolymphoid hyperplasia with eosinophilia.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title]Epithelioid hemangioma (angiolymphoid hyperplasia with eosinophilia) arising on the extremities.

BACKGROUND: Epithelioid hemangioma (EH) is a benign vascular proliferation usually accompanied by a mixed inflammatory infiltrate.

METHODS: Skin biopsy specimens from four patients with EH on the extremities were studied.

Architecture, extent of vascular proliferation and the presence of epithelioid endothelial cells were evaluated.

Larger vessels were lined by epithelioid endothelial cells.

CONCLUSIONS: EH can lead to diagnostic confusion with cutaneous lymphoma and other entities, especially when its mixed inflammatory infiltrate predominates over its vascular component and contains large activated CD30+ lymphocytes.

Awareness that the presence of CD30+ activated lymphocytes is not specific for lymphoma and recognition of the vascular component is critical for proper diagnosis of EH.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

The RIL, parental lines, and three control cultivars ('Esteem', 'Sol Dorado', and 'Hales Best Jumbo') were grown at Hancock, WI and El Centro, CA in 2002, and evaluated for primary branch number (PB), fruit number per plant (FN), fruit weight per plant (FW), average weight per fruit (AWF), and percentage of mature fruit per plot (PMF).

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

Third was the opportunity of working with Professor Herman Waldmann and Dr Geoff Hale, first in Cambridge and latterly in Oxford, on immunosuppression achieved by ex vivo T-cell depletion within the broad ambit of the Campath users group.

With difficulties in finding sibling donors, a further achievement was the creation of The South African Bone Marrow Registry and now a proposal to also start a national transplant registry that will complement the survey currently being conducted, on a worldwide basis, by the European Group for Blood and Marrow Transplantation.

[MeSH-minor] Graft vs Host Disease / etiology. Humans. South Africa

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[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

After the distribution of Thomas Hale's Medications and Mother's Milk (MMM) (Hale Publishing, Amarillo, TX, 2006) by the Rhode Island Department of Health (Providence, RI) in November 2006 to Rhode Island pharmacies, we investigated, during the summer of 2007, what strategies and resources pharmacists were using to identify breastfeeding women and guide medication recommendations.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

Serial fetal biometry (ultrasound), required for the diagnosis, timing and severity of intrauterine growth restriction in the individual infant, is still not common in epidemiological studies.

The theoretical concepts of a thrifty phenotype (Hales and Barker) and of a predictive adaptive response (Gluckman and Hanson) offer a comprehensive approach to understanding the empirical and experimental findings.

[Number-of-references] 110

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

BACKGROUND: Comorbidity complicates estimations of health-adjusted life expectancy (HALE) using disease prevalences and disability weights from Burden of Disease studies.

METHODS: Using data of the Dutch national burden of disease study, the effects of different methods to adjust for comorbidity on HALE calculations are estimated.

The default multiplicative adjustment method to define disability weights for comorbidity is compared to HALE estimates without adjustment for comorbidity and to HALE estimates in which the amount of disability in patients with multiple diseases is solely determined by the disease that leads to most disability (the maximum adjustment method).

RESULTS: Compared to the multiplicative adjustment method, the maximum adjustment method lowers HALE estimates by 1.2 years for males and 1.9 years for females.

Compared to no adjustment, a multiplicative adjustment lowers HALE estimates by 1.0 years for males and 1.4 years for females.

CONCLUSION: The differences in HALE caused by the different adjustment methods demonstrate that adjusting for comorbidity in HALE calculations is an important topic that needs more attention.

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[ISO-abbreviation] J Chem Phys

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

Tuberculosis (TB) abdomen presenting as gluteal abscess is very rare and difficult to diagnose in the absence of high index of suspicion; ruling out the possibilities of other diagnosis by means of suitable investigations is the only way to arrive at this diagnosis in an immuno-competent patient.

We report an interesting case of TB abdomen presenting as gluteal abscess in a 27-year-old young female patient, who is otherwise hale and healthy.

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[Language] eng

[Publication-type] Journal Article

[Publication-country] Poland

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

Two recent articles in this journal (Fiorello et al., 2007; Hale et al., 2007) contended that the WISC-IV FSIQ should not be interpreted for children with disabilities because, when index scores are diverse, the FSIQ lacks validity and is an insufficient description of a child's abilities.

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[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

A traditional preparation of Parmotrema saccatilobum (Taylor) Hale (Family: Parmeliaceae) is being considered for inclusion into the PNG national drug formulary by the Ministry of Health Taskforce on Traditional Medicines.