In 1948, Markle made a leap from radio to television. Sponsored by Westinghouse Electric Corporation, the television series was seen on CBS (which Westinghouse owned between 1995 and 2000), from 1948 through 1958, under several variant titles: Studio One Summer Theatre, Studio One in Hollywood, Summer Theatre, Westinghouse Studio One and Westinghouse Summer Theatre. It was telecast in black-and-white only.

Offering a wide range of dramas, Studio One received Emmy nominations every year from 1950 to 1958. The series staged some notable and memorable teleplays among its 466 episodes. Some created such an impact they were adapted into theatrical films. William Templeton's 1953 adaptation of George Orwell's novel Nineteen Eighty-Four, starring Eddie Albert as Winston Smith, led to the 1956 feature film version with Edmond O'Brien in the principal role. Reginald Rose's drama Twelve Angry Men, about the conflicts of jurors deciding a murder case, originated on Studio One on 20 September 1954; and the 1957 motion picture remake with Henry Fonda was nominated for three Academy Awards. Sal Mineo had the title role in the 2 January 1956 episode of Reginald Rose's Dino, and he reprised the role for the movie Dino (1957).

In 1954, "Crime at Blossoms", scripted by Jerome Ross, was given an Edgar Award for Best Episode in a TV Series. Nathaniel Hawthorne's granddaughter received a plaque in recognition of her grandfather's writing achievements, during the 3 April 1950 telecast of The Scarlet Letter.

During the 1953 presentation Dry Run, whole sections of a submarine were built inside the studio and the entire cast was nearly electrocuted when water that was being used for special effects got very close to power cables.[3]

Worthington Miner, Martin Manulis and others produced. As spokeswoman for Westinghouse, Betty Furness became strongly identified with Westinghouse products, and she also was seen in eight Studio One dramas. The show's musical directors were Milton C. Anderson, who also created music for Playhouse 90, and Eugene Cines. The show's run ended when Westinghouse switched its sponsorship to the Westinghouse Desilu Playhouse, which premiered in 1958.[4] The series finished at #24 in the Nielsen ratings for the 1950-1951 season.[5]

For years, the second half of the original TV production of Twelve Angry Men was considered lost. However, in 2003, Joseph Consentino, a researcher-producer for The History Channel, discovered a complete kinescope of the Studio One production in the home of the late New York defense attorney (and later judge) Samuel Leibowitz. Consentino was researching a History Channel documentary about Leibowitz, and the discovery was announced by the Museum of Television & Radio (now The Paley Center for Media).[6]

A third season episode of the ABC legal drama Boston Legal, "Son of the Defender", used clips from the two-part Studio One episode "The Defender" [25 February-4 March 1957], featuring William Shatner as an attorney joining his lawyer father, played by Ralph Bellamy, in the defense of a 19-year-old, played by Steve McQueen, who is accused of murder. Utilizing clips of the older show for flashbacks, the Boston Legal episode portrayed Shatner's Studio One character as a young Denny Crane trying his first case alongside his father.[7]

Many Studio One episodes are available for viewing at the Paley Center for Media in New York City and Los Angeles, and some are available through Netflix.

In 2008, Koch Vision released the Studio One Anthology. Episodes include "1984", "The Arena", "Confessions of a Nervous Man", "Dark Possession", "The Death and Life of Larry Benson", "Dino", "Julius Caesar", "June Moon", "The Medium", "Pontius Pilate", "The Remarkable Incident at Carson Corners", "The Storm", "The Strike", "Summer Pavilion", "Twelve Angry Men" and "Wuthering Heights." The episodes contain the original Westinghouse commercials. Bonus features include the "Studio One Seminar" from the Paley Center for Media; an interview with director Paul Nickell, footage from the Archive of American Television and a featurette on the series.

The episode "Twelve Angry Men" is also included as a bonus on the Criterion Collection DVD and Blu-ray releases of the 1957 film.[8]

Amazon.com is also issuing several made-to-order DVD's of episodes not included in the Koch Vision Anthology.