Three years later, the lymph node shots hadn't worn off, though patients in both groups reported similar degrees of improvement in their allergy symptoms.

People might be more willing to get lymph node shots because fewer shots are required and they are "practically painless," write the researchers, who included Thomas Kundig, MD, of Switzerland's University Hospital Zurich.

The journal notes that Kundig is the inventor named for intralymphatic immunotherapy (the lymph node shots) on a patent owned by the University of Zurich.