Yamamoto launched the romantic comedy manga in Gessan Mini, the supplement brochure to Gessan magazine in July 2012. After ending the serialization of Fudatsuki no Kyouko-chan in June 2016, Yamaoto transferred Karakai Jouzu no Takagi-san to Gessan the following month. Shogakukan published the ninth volume last July, which included an OVA episode. The tenth volume is scheduled for a February 12 release. Karakai Jouzu no Takagi-san has a cumulative 4.5 million copies of its compiled volumes in circulation, including digital editions.

A 12-episode anime series aired in Winter 2018 on the Anime no Me programming block, which also adapted Yamamoto's Ashita wa Doyoubi manga within the show. Crunchyroll simulcast the anime with subtitles, while Funimation simultaneously streamed an English dub. Funimation will also release the anime in North America on a Blu-ray volume on February 19.

Yen Press licensed the manga in English last January and will publish the third volume on January 22.

It's not easy to find a series more unfit for animation.The boy is a cretin so fooling him takes no skill or smarts and generally barely anything happens. In the manga it's ok because chapters take just a moment to read and rely of humorous or cute shots. Dragging it for a full episode is painfully dull. I already forgot I dropped the anime after 2 episodes.