How do researchers determine the difference to be detected in superiority trials? Results of a survey from a panel of researchers

There is currently no guidance for selecting a specific difference to be detected in a superiority trial. We explored 3 factors that in our opinion should influence the difference to be detected (type of outcome, patient age group, and presence of treatment side-effects), and 3 that should not (baseline level of risk, logistical difficulties, and cost of treatment).

GAYET-AGERON, Angèleet al. How do researchers determine the difference to be detected in superiority trials? Results of a survey from a panel of researchers. In: BMC Medical Research Methodology, 2016, vol. 16, p. 89. https://archive-ouverte.unige.ch/unige:90403