The protein encoded by LRAT is a microsomal enzyme that catalyzes the esterification of all-trans-retinol into all-trans-retinyl ester, an essential reaction for the retinoid cycle in visual system and vitamin A status in liver. Additionally we are shipping LRAT Proteins (8) and LRAT Kits (5) and many more products for this protein.

lecithin retinol acyltransferase affects all-trans retinoic acid levels and has a role in retinoid sensitivity in malignant melanoma cells.

These findings reveal structural adaptation that facilitates selective catalysis and mechanism responsible for diverse substrate specificity within the LRAT-like enzyme family

high LRAT expression in melanoma might be important in removing retinol as substrate for RA production, thereby inducing signalling pathways leading to dedifferentiation, proliferation and anti-apoptosis

Functional hepatic stellate cells coexpressing both LRAT and CRBP-1 (show RBP1 Antibodies), that continue to maintain the ability to store vitamin A, contribute in part to the development of portal and parenchymal fibrogenesis in patients with viral hepatitis.

Lecithin-retinol acyltransferase is a thermostable and highly active enzyme with a likely mode of interfacial activation.

A genetic defect was identified in LRAT as a novel cause of retinitis punctata albescens.

This study showed that malignant melanoma cells are able to esterify all-trans retinol and subsequently isomerize all-trans retinyl esters (RE) into 11-cis (show CISH Antibodies) retinol, whereas their benign counterparts-melanocytes are not able to catalyze these reactions.

These experiments are consistent with an expanded role for LRAT function as a protein palmitoyl transferase.

LRAT is not required for isomerase activity beyond synthesis of retinyl-ester substrate, and the association of Rpe65 (show RPE65 Antibodies) with membranes is neither dependent upon LRAT nor the result of S-palmitoylation

Data show that overexpression of human LRAT specifically in mice oral basal epithelial cells makes these cells more sensitive to carcinogen induced tumorigenesis.

Lecithin-retinol acyltransferase is essential for accumulation of all-trans-retinyl esters in the eye and in the liver

LRAT has a role in retinoid absorption and storage

LRAT Antigen Profile

Protein Summary

The protein encoded by this gene is a microsomal enzyme that catalyzes the esterification of all-trans-retinol into all-trans-retinyl ester, an essential reaction for the retinoid cycle in visual system and vitamin A status in liver. Mutations in this gene have been associated with early-onset severe retinal dystrophy.