Ab00811-2.0 Anti-E-protein DIII (C-C’) [ZV-64]

This reformatted mouse antibody was made using the variable domain sequences of the original Mouse IgG2c format, for improved compatibility with existing reagents, assays and techniques.

Species and Isotype: Mouse IgG2a, kappaClone Number: ZV-64UniProt Accession Number of Target Protein: Published Application(s): NTRL; crystallization; SPR; FCPublished Species Reactivity: Zika VirusImmunogen: This antibody was generated by infecting mice with 1000 FFU of ZIKV MR-766 followed by a booster at 30d post-infection of ZIKV H/PF/2013, respectively and given a final intravenous boost with live ZIKV DIII (amino acids 299 to 407 of the ZIKV E protein))Specificity: ZV-64 binds to the Zika virus envelope protein at domain III (DIII, C-C’ loop). No cross-reactivity with other tested flaviviruses has been reported.Application Notes: The original mouse IgG2c format has been shown to have neutralizing activity and has been used to label ZIKV infected cells (4% PFA fixation, 0.1% saponin permeabilization).Antibody First Published in: Zhao et al. Structural Basis of Zika Virus-Specific Antibody Protection. Cell. 2016 Aug 11;166(4):1016-27 Note on publication: Describes the generation and characterisation of this antibody.

Mouse IgG2a

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Product Form

Purification: Protein A affinity purifiedSupplied in: PBS with preservative (0.02% Proclin 300)Storage Recommendation: Store at 4°C for up to 3 months. For longer term storage aliquot into small volumes and store at -20°CConcentration: See vial label.

Important note – This product is for research use only. It is not intended for use in therapeutic or diagnostic
procedures for humans or animals.