Abstract : A medical database of 589 women thought to have osteoporosis has been analyzed. A hybrid algorithm consisting of Artificial Neural Networks and Genetic Algorithms was used for the assessment of osteoporosis. Osteoporosis is a common disease, especially in women, and a timely and accurate diagnosis is important for avoiding fractures. In this paper, the 33 initial osteoporosis risk factors are reduced to only 2 risk factors by the proposed hybrid algorithm. That leads to faster data analysis procedures and more accurate diagnostic results. The proposed method may be used as a screening tool that assists surgeons in making an osteoporosis diagnosis.