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I object to the term 'methadone addict'. I'm sure some users of street-methadone potentiate with meclizine, but I believe that some of those in methadone maintenance programs do as well. I don't think those in methadone maintenance should be called 'methadone addicts', regardless of the fact that they are physically addicted to methadone. I'm changing the term to 'methadone users'. 24.196.111.104 (talk) 00:21, 3 June 2009 (UTC

I second that, because the term addict is a loaded word, and there is nothing about methadone maintenance that is euphoric, at least for those who are just trying to stay normal. Methadone has an unnecessary bad rap and the layperson still thinks it's "synthetic heroin." So I think 'methadone patients' is appropriate, but not in a context including non-maintenance methadone users. I think "methadone users" is good. Mr0t1633 (talk) 20:53, 6 January 2010 (UTC)

The following text was lost, apparently due to a copypaste page move on 8 November 2010.

Meclizine is the first-generation antihistamine of the piperazine class. It differs from the protoype of this class, cyclizine, primarily in having an average half-life of 6 hours vs. 20 hours for cyclizine (though half-life should not be confused with frequency of duration). Meclizine is less anticholinergic than many other antihistamines and other agents used for their anti-emetic and anti-pruritic effects.[citation needed] Along with the aforementioned efficacy against nausea and itching, meclizine also shares the anxiolytic, analgesic-sparing (potentiating), sedative, and other effects of its chemical relatives cyclizine and hydroxyzine to varying extents.[citation needed] Related to this is the reported ability of meclozine to potentiate the anti-spasmodic, anti-diarrhoeal, and other effects of diphenoxylate, loperamide, and difenoxin.[citation needed] Meclizine is sometimes combined with opioids, especially ones of the open-chain class like methadone, dextropropoxyphene and dipipanone (originally combined with meclizine's parent drug cyclizine, the brand name of this combination is Diconal). The trend of mixing piperazine antihistamines has caught on in the United States[citation needed], with some methadone users potentiating their doses with meclizine or hydroxyzine (cyclizine has only just recently been introduced to the U.S. OTC market in 2009, sold under the brand name Marezine at higher prices than generic equivalents of meclizine and hydroxyzine).

I know that this was added well over 2 years ago, but I appreciate that you've added this information here. I just don't understand why it's not on the main Meclozine Wiki page, though. I was looking all over the place trying to find some type of mechanism of action/usage/etc. comparison between meclizine and the other drugs in this family, particularly hydroxyzine, beyond the label uses of nausea and dizziness caused by motion sickness, such as comparison of meclizine to the others (again, particularly hydroxyzine) in effectiveness as an antihistamine and specific antihistamine action (which I'm surprised I couldn't find anything about besides here, considering that they're all in the same family, which is first-generation *antihistamines*), any anti-pruritic actions, possible anti-anxiety actions comparable to hydroxyzine, any possible comparable potentiating actions co-administered with opioid analgesics with hydroxyzine and promethazine (no, it's not for recreational use. I take 24/7 pain meds for chronic pain and I have a high tolerance to my pain medications, even when I take my breakthrough pain med, but I'm still rather young, and have a list of numerous surgeries I'm expecting over the course of the net few years, so I'm looking for ways to potentiate my pain meds, so I can either take less of a dose of my BT med, and/or lessen the frequency and perhaps just take a potentiating drug for the milder BT pain taken only with my long-acting medication that's taken on a schedule and always in my system at the same level, as I'm wondering if I were to take a drug that potentiates analgesia from opiates [one that actually *does* increase analgesia from opiates, at least for me] by itself, and just with my long-acting pain medication, if the potentiating/adjuvant drug would work enough just with my long-acting medication taking it "alone", rather than with the BT pain medication, that it would work taken "alone" as an analgesic for the least severe breakthrough pain that I would take an extra pain medication for. I figure anything in this drug family, or just anything that supposedly potentiates opiate analgesia, would all be at least one step up from Tylenol in effectiveness, since that doesn't work for me at all.). This is the only place I could find any kind of information like that, though. I'd totally forgotten about the "talk" page on Wikipedia topic pages until just now, too, so I spent much more time searching around for something I could have just read here in the first 5 minutes of my search, because this was the first search result I clicked on. The information you've added here really needs to be added onto the main Meclozine page, too, because when I did a Google search for Meclizine (how it's spelled on the boxes I just got from the store), the Wikipedia result automatically goes to this result, spelled Meclozine, so anyone who does an internet search for meclizine using either spelling will automatically be led to this page so even if this information might be elsewhere on here, I would assume the majority of people would never see the additional information that's stated here, maybe also on some other page elsewhere, because the majority of people using Wikipedia don't click on the "talk" link on the top of the page, or even see it there or know it's there in the first place. Just look at me-I'm signed up here, I know the talk pages are there, I've browsed the "talk" sections plenty of times before, but I went quite a long time before making my way here and seeing this cut-off info, that happens to contain exactly the information I spent a long time looking for, because it totally slipped my mind to look here. Someone needs to edit this page and copy all the drug effects listed here onto the main page. And considering that it was added over 2 years ago, it's been too long of a wait already. Hopefully someone with much more authority than myself to edit pages here will soon read this and finally edit in this additional information. --Poisonalice (talk) 10:34, 17 February 2013 (UTC)

Hi. As far as I remember, I put this here because of its many [citation needed] tags. However, I agree with your reasoning, so I've put it back. Hopefully someone with better access to sources will check the information and add references. (Meclozine isn't marketed in my county any longer.) I wish you the best of luck with your pain medication. (Have you got a diagnosis?) --ἀνυπόδητος (talk) 19:47, 17 February 2013 (UTC)

Thanks, it's much appreciated, and I'm sure that there will be other people who will come along and appreciate the information added back as well. I'm sure that there will also be someone that will come along and provide the needed citations, as well. Thanks for the well wishes. It does help to a certain degree. I have degenerative disc disease, numerous herniated and degenerating discs up and down my spine, sciatica from breaking my tailbone so many times, fibromyalgia, carpal tunnel in both hands, tendinitis, shoulder separation, and arthritis in my left shoulder (I need surgery on it), and bone spurs on my right knee from an old injury and surgery, which I also need (another) surgery on to scrape the bones spurs off my kneecap. There may be one or two things missing from that list LOL! SO yeah, I'm on some pretty heavy duty pain medications, but I have high tolerances to all medications, and I develop tolerances very fast, too, probably because I'm a fast metabolizer of drugs. Thanks for asking :) I'm sure I gave you more information than you expected though HAHA! Poisonalice (talk) 03:06, 8 March 2013 (UTC)

The drug is "Meclizine," not "Meclozine." At least in English-speaking countries...for which this article is intended. — Preceding unsigned comment added by 67.79.29.210 (talk) 18:45, 18 October 2012 (UTC)

Are you sure? Your source only mentions that the stem -izine is generally used for diphenylmethyl piperizines, but not this substance specifically. The source you removed (KEGG) explicitly says that meclozine is the INN. My books agree with this, but they are unfortunately offline sources. --ἀνυπόδητος (talk) 12:14, 18 November 2013 (UTC)

Pretty sure. That is unfortunate. It's the only WHO source I could find on this matter. If you can find another international source I'd be interested. Bradgon (talk) 17:34, 18 November 2013 (UTC)

-izine is used for ALL diphenylmethyl piperizine derivatives, therefore meclizine is included in this. Bradgon (talk) 20:45, 19 November 2013 (UTC)