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Researchers used Size-Exclusion Chromatography to successfully isolate extracellular vesicles from umbilical cord mesenchymal stem cell (UCMSC)-conditioned medium. These vesicles were defined as positive for CD9, CD63, CD73 and CD90, and their size and morphology characterized by NTA and cryo-EM. [Theranostics]
Full Article

Researchers investigated the therapeutic potential of human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs) as a new therapeutic strategy for patients with rheumatoid arthritis and to explore the mechanisms underlying hUCB-MSC-mediated immunomodulation. [Cell Death Dis]
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Scientists investigated the therapeutic potential of the Agouti-related peptide, which is secreted by human mesenchymal stem cells (MSCs), in terms of its effect on the regulation of proteasome activity in Alzheimer’s disease. When SH-SY5Y human neuroblastoma cells were co-cultured with MSCs isolated from human Wharton’s Jelly, their proteasome activity was significantly upregulated. [Sci Rep]
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An in vitro B cell development model system was established by co-culturing human cord blood-derived hematopoietic stem cells with irradiated human primary bone marrow stromal cells. Using this in vitro model, investigators found that 2,3,7,8-tetrachlorodibenzo-p-dioxin significantly suppressed the total number of hematopoietic stem and progenitor cells in a concentration-dependent manner. [Toxicology]
Abstract

Phenotype and immunomodulatory and angiogenic potencies of a specific umbilical cord tissue–derived mesenchymal stromal cell population were not impaired by cryopreservation and subsequent thawing, both in vitro and in vivo. [Cytotherapy]
Abstract

Using Sepax, the authors observed higher recovery of total nucleated cells (TNC), CD34+ cells, natural killer cells and monocytes when compared to manual enrichment, despite similar TNC and CD34+ viability with the two methods. [Cytotherapy]
Abstract

Although significant questions remain regarding the origin, heterogeneous phenotype and expansion potential of amniotic fluid stem cells, evidence to date supports their potential role as a valuable stem cell source for the field of regenerative medicine. [Stem Cells]
Abstract

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Vivex Biomedical, Inc. has received level II HCPCS Q-Code for Cygnus. Cygnus, an amniotic tissue matrix with innate regenerative capability to support healing, is a product that is available in multiple sizes for multiple uses. Cygnus’ amnion patch is an immune-privileged tissue with proven clinical success in regenerative healing. [Vivex Biomedical, Inc.]
Press Release

Hundreds of young researchers occupied Argentina’s science ministry in Buenos Aires last month, angry at budget cuts that they say have denied them permanent jobs at the country’s National Scientific and Technical Research Council. The occupation was the most extreme action yet by Argentinian scientists after months of protests at last year’s budget, the first under President Mauricio Macri. And the occupation seems to have paid off, in part: many of those involved have been offered extensions to their fellowships. [Nature News]
Editorial

Thousands of scientists in Germany, Peru and Taiwan are preparing for a new year without online access to journals from the Dutch publishing giant Elsevier. Contract negotiations in both Germany and Taiwan broke down in December, while Peru’s government has cut off funding for a licence. [Nature News]
Editorial