The Health Benefits of Wine: Not Too Much but Not Too Little

Most people drink wine in moderation for gustatory pleasure and for social purposes, allowing them to relax
and enjoy life. The health benefits of wine beyond these gains are not of much concern for many. As Julia Child noted,
“The fact that people drink wine to relax and enjoy life is, in itself, enough a health benefit for everyone.”

Nevertheless, man has been using wine as a medicine for over 5,000 years. The Old and New Testament
speaks of wine as a sedative, antiseptic, and healing agent. Hippocrates, the Father of Western Medicine,
advocated the use of wine to treat practically every illness he had identified. He noted, “Wine is fit for man in a
wonderful way, provided that it is taken with good sense by the sick as well as the healthy.” Another Greek
physician, Pliny the Elder, described wine as a medicine in Naturalis Historia, and said, “Nothing is more useful
than wine for strengthening the body and more detrimental to our pleasures if moderation be lacking.”
Paracelsus was a German physician in the Middle Ages who is considered the father of modern pharmacology.
He stressed the tonic value of wine and invented the word alcohol. He proclaimed, “Whether wine is
nourishment, medicine or poison, is a matter of dosage.

The singular message that rings out from the proclamations of these historically prominent men is that wine can
be healthful when taken in moderation. 1991 was to be the seminal year that brought this message home to
the American public. At a time when the federal government’s Dietary Guidelines for Americans admonished
the health benefits of alcoholic beverages, Morley Safer hosted a television feature on 60 Minutes about a
health conundrum known as the “French Paradox.” The program featured two medical experts, Curtis Ellison,
M.D., Professor of Preventive Medicine and Epidemiology at Boston University School of Medicine and Serge
Renaud, M.D., Professor of Cardiology and Research Director at Sagalen University in Bordeaux, France.

The program pointed out that the French had 40% fewer heart attacks and lived on average 2.5 years longer.
They consumed a diet high in saturated fat, smoked more and exercised less than Americans, but they
consumed moderate amounts of red wine regularly with meals, at more vegetables and fruit, ate less red meat
and more cheese, used more olive oil and less lard or butter, took longer to eat meals, and snacked less.
Curtis Ellison, M.D. confirmed the potential of wine to protect against heart disease, and said, “The link
between moderate and regular consumption of wine with meals was the strongest and supported by the most
scientific data.” Serge Renaud, M.D., was happy to state, “It’s well-documented that a moderate intake of
alcohol prevents coronary artery disease by as much as 50%. The solution to the French Paradox was hidden
in a bottle. At the show’s conclusion, Safer raised a glass of red wine to the camera and commented, “So the
answer to the riddle, the explanation of the paradox, may lie in this inviting glass.”

Also in 1991, Sir Richard Doll, the world’s leading epidemiologist, after reviewing mounting evidence, said, “I
conclude that light or moderate consumption of alcohol reduces the risk of coronary artery disease. Men and
women who regularly drink small amounts of alcohol tend to have a lower morbidity and mortality from coronary
artery disease and a lower mortality from all causes combined than those who permanently abstain.”

In 1995, Research Fellow Dr. Morten Gorenbaek published the Copenhagen Study, comparing the health
effects of beer, wine and spirits. He concluded, “Low to moderate - 3 to 5 drinks - of wine is associated with
lower mortality - up to 50% - from cardiovascular and cerebrovascular disease and other causes. Similar
intake of spirits implied an increased risk of up to 34%, while beer drinking did not affect mortality.” The same
year, Morley Safer traveled to Copenhagen and reported on the Copenhagen City Heart Study on 60 Minutes.He reported that wine consumption had risen by 30% in Denmark in the preceding 20 years while heart
disease had declined by 20% in the previous 15 years. The findings were thought to be due to a switch to
wine.

Ten years late, in 2005, the United States Government finally conceded in the United States Dietary
Guidelines. “Alcohol may have beneficial effects when consumed in moderation in middle-aged and older
adults. The lowest all-cause mortality occurs at an intake of one to two drinks per day. The lowest coronary
heart disease mortality also occurs at an intake of one to two drinks per day. Morbidity and mortality are
highest among those drinking large amounts of alcohol. Those who chose to drink alcoholic beverages should
do so sensibly and in moderation - defined as the consumption of up to one drink per day for women and up to
two drinks per day for men.” The 2010 Dietary Guidelines for Americans which were published January 11,
2011 (www.cnpp.usda.gov/DGAs2010-DGACReport.htm) took a similar stance and are summarized later in
this issue.

Most of the health benefits of wine have been attributed to a combination of alcohol and the so called “miracle
molecules,” the polyphenolic compounds found in the skin and seeds of red grapes. Many research studies
suggest it is the polyphenols in wine that give it superior health benefits over other alcohol beverages, but this
has not been completely proven. During fermentation, alcohol extracts the polyphenolic compounds into wine
in a form in which the body can absorb them. Because of the alcohol, the polyphenols exist in a stable form.
Polyphenols are also found in oak, and can be absorbed by wine while aging in oak barrels. For example, the
vanilla flavor in wine is attributable to the polyphenol, vanillin.

One glass of red wine has 200 mg of polyphenols compared to 40 mg for white wine. Two glass of red wine a
day will enhance the polyphenol content of the average diet by 40%. Of the three classes of polyphenols,
flavanols, flavonols and anthocyanins, the anthocyanin resveratrol is the best known and most extensively
studied. It is found primarily in the skin of red grapes where it is produced in response to stresses such as
fungal infections. The highest levels of reservatrol are found in wines from cooler climates and Pinot Noir
produces wine with the highest resveratrol counts regardless of where it is grown. Wine is superior to table
grapes, grape juice and raisins in total polyphenolic content (table grapes are grown in hot climates,
polyphenols are not stable in grape juice, and polyphenols disappear in strong sun making raisins a less
desirable source).

Thus far, the research on reservatrol has been performed in yeast, worms, fruit flies, and mice, and the dosage
required in humans to duplicate the favorable effects on health and aging observed in these studies would
require the impractical ingestion of hundreds of bottles of Pinot Noir daily. Although resveratrol is the focus of
most investigation, it is feasible that a combination of polyphenols found in red wine, rather than resveratrol
alone, is responsible for the observed health benefits.

The action of polyphenols in the human body are poorly understood at this time. We do know they are potent
antioxidants that can attack and destroy free radicals (waste products in human body that interact with
important cellular components such as DNA or the cell membrane, causing the cells to function poorly or die
leading to disease of aging such as vascular disease, cancer, dementia, diabetes and arthritis). They are also
anti-inflammatory agents that can tell cells to produce a particular protein to fight off illness. In 2004, Harvard
Medical School researcher David Sinclair along with Dr. Christophy Westphal launched Sirtris Pharmaceuticals,
a Cambridge, Massachusetts research company to develop drugs based on polyphenols that could treat
specific diseases and in particular ones that influenced the longevity gene, SIRT1.

Sirtris Pharmaceuticals was acquired by GlaxoSmithKline for $720 million in 2008. An experimental drug,
SRT501, containing resveratrol as the main ingredient, has been recently shown to be minimally effective in
patients with cancer and the company has halted trials of the drug. The company’s research on resveratrol-based
drugs is continuing.

Many knowledgeable researchers in the field believe that the small amounts of polyphenols present in red wine
do have significant health benefits. At the 90th Annual Meeting of the Endocrinology Society (ENDO) in San
Francisco in 2008, a study reported that the precursors of fat cells exposed to resveratrol in the lab prevented
fat cells from increasing and converting into mature fat cells. The authors of this study believe this explains the
French Paradox.

Since federal money cannot be used to support alcohol research other than treatment and addiction and
viticultural studies, there has not been a well-executed, randomized, double-blinded, intervention trial controlled
for confounding variables. The debate as to the health benefits of wine and beverage alcohol as part of a
healthy lifestyle continue, but I am with the majority of health experts who are confident that wine in moderation
over the course of a lifetime is good for you. My prescription is 5 to 10 ounces of red wine (one to two standard
drinks) most days, consumed with food. The presumed cardioprotective benefits of wine are most pronounced
when wine is drunk daily and taken with a meal. That said, wine drinking may not be advisable for everyone,
and each individual should consult with their doctor about the effects of wine consumption on their health.
Regardless of whether you choose to drink wine, it is advisable that you pursue a healthy lifestyle: avoid
smoking, stay lean, exercise regularly, and follow a Mediterranean diet high in fruits and vegetables and low in
animal fat and high in fiber. Consumption of green tea and small amounts of chocolate may provide additional
sources of polyphenols

In the pages to follow, I will summarize peer-reviewed scientific studies published in print, online or presented
at scientific forums in 2010 and early 2011, along with other relevant reports that contribute to our current
understanding of the roles alcoholic beverages, and in particular wine, play in our health. In 2010, there were
over 700 studies published in the medical literature related to alcohol and wine, but I will only include the most
relevant and important here. For additional information, consult last year’s summary in the PinotFile
(www.princeofpinot.com/article/845/). The 6th International Wine and Heart Health Summit will be held
November 2-5, 2011 in the Willamette Valley. This event is open to physicians and any wine lover interested in
hearing the latest research on wine and health. I will keep you posted on specifics of this meeting in future
issues.

Longevity

Resveratrol and red wine, healthy heart and longevity Heart Fail Rev (September 2010) It appears that
resveratrol can induce the expression of several longevity genes including Sirt1, Sirt3, Sirt4, Fox01, Foxo3a
and PBEF, and prevent aging related decline in cardiovascular function including cholesterol level and
inflammatory response, but it is unable to affect actual survival or life span of mice.

Late-Life alcohol consumption and 20-year mortality Alcoholism: Clin & Exp Res (November 2010) A study
of primarily men, between ages 55 and 65 found that nondrinkers tend to die sooner, with double the estimated
mortality risk of moderate drinkers. Nondrinkers tend to be from lower socioeconomic classes, have more life
stress, show more depression, have less physical activity and poorer health habits, but even after these
covariates are controlled, researchers found mortality rates were the highest for those who were not current
drinkers (51% increased mortality risk), second highest for heavy drinkers (45% increased mortality risk), and
lowest for moderate drinkers.

Cardiovascular Disease

Alcohol consumption and risk of cardiovascular disease among hypertensive women Eur J Cardiovasc
Prev Rehabil (February 2010) Moderate alcohol consumption is associated with a reduced risk of coronary
heart disease among hypertensive women. Light alcohol consumption tended to be related to a lower risk of
stroke. Current guidelines for alcohol consumption in the general population also apply to hypertensive
women.

Alcohol and cardiovascular health Physiol Behav (April 2010) This report is from well-known alcohol and
health researcher, Dr. AL Klatsky. The lower risk of morbidity and mortality of light drinkers is due mostly to
lower risk of the most common cardiovascular condition, coronary heart disease. A protective hypothesis for
coronary heart disease is supported by evidence for plausible biological mechanisms attributable to ethyl
alcohol. International comparisons and some prospective study data suggest that wine is more protective
against coronary heart disease than liquor or beer. Possible non-alcohol beneficial components in wine
(especially red) support possible extra protection by wine, but a healthier pattern of drinking or more favorable
risk traits in wine drinkers may be involved.

Dietary factors and incident atrial fibrillation: the Framingham Heart Study Am J Clin Nutr (February
2010) Associations between consumption of alcohol, caffeine, fiber and polyunsaturated fatty acids, and
incident AF were evaluated. Consumption of alcohol, caffeine, fiber and fish-derived polyunsaturated fatty
acids was not significantly associated with AF risk in the study group with a mean age of 62 years.

Relationship between alcohol intake, health and social status and cardiovascular risk factors in the
urgan Paris-Ile-De-France Cohort: is the cardioprotective action of alcohol a myth? Eur J Clin Nutr (June
2010) The aim of this study was to evaluate potential confounders which may contribute to putative
cardioprotection by alcohol. Subjects in the Center for Cardiovascular Disease Prevention (The Urban Paris-
Ile-de-France Cohort) were evaluated. Multivariate analysis confirmed that moderate and low drinkers
displayed better health status than did nondrinkers. The authors concluded that moderate alcohol drinkers
display a more favorable clinical and biological profile (low body mass index, heart rate, pulse pressure, fasting
triglycerides, fasting glucose, stress and depression scores, superior respiratory function, social status and
physical activity), consistent with lower cardiovascular risk as compared with nondrinkers and heavy drinkers.
Therefore, moderate alcohol consumption may represent a marker of higher social level, superior health status
and lower cardiovascular risk.

Light-to-moderate alcohol consumption and risk of sudden cardiac death in women Heart Rhythm
(October 2010) In this prospective cohort study from the Nurses Health Study, the relationship between light to
moderate alcohol intake and sudden cardiac death is U-shaped. Women who consumed one to two alcoholic
beverages per day were 46% to 42% less likely (respectively) to suffer sudden cardiac death. At three drinks
per day, the risk was about the same as nondrinkers. Previous studies had shown that men who drank light to
moderate amounts of alcohol had less risk for sudden cardiac death compared to abstainers. The study also
revealed that women who had light to moderate intake of alcoholic beverages had 60% less incidence of fatal
heart disease. No difference was found among different types of alcoholic drinks. The authors note that the
findings may not be all attributable to alcohol, but rather to a healthier lifestyle enjoyed by those who drank
moderately.

Diet and heart health: moderate wine drinking strengthens the cardioprotective effects of fish
consumption Current Pharmaceutical Biotechnology (November 2010) French researchers have described
that moderate wine drinking can strengthen the cardioprotective effect of fish consumption. The review
addresses the role of two of the specific components of the Mediterranean diet, omega-3 fatty acids and wine,
and establishes a link between moderate wine consumption and fatty acid profiles. Moderate consumers of
alcohol had higher omega-3 in their system compared to nondrinkers, even when similar amounts of seafood
were consumed. The study also found that the hearts of those who regularly consumed wine and omega-3 fatty
acids had 20% more heart tissue and a lower rate of heart disease was evident in those who ate fish and drank
wine regularly. The researchers recommended around two to four glasses per day paired with fish high in
omega-3 fatty acids such as fish with oily flesh including anchovies, herring and mackerel.

Patterns of alcohol consumption and ischemic heart disease in culturally divergent countries: the
Prospective Epidemiological Study of Myocardial Infarction (PRIME) Brit Med J (November 2010) This
study was undertaken to study the effect of alcohol intake patterns on ischemic heart disease in two countries
with contrasting lifestyles, Northern Ireland and France. Regular and moderate alcohol intake throughout the
week, the typical pattern in middle aged men in France, is associated with a low risk of ischemic heart disease,
whereas the binge drinking pattern more prevalent in Belfast confers a higher risk.

Lifestyle practices and cardiovascular disease mortality in the elderly: The Leisure World cohort study
Cardiol Res Pract (January 2011) The authors explored the association of smoking, alcohol consumption,
caffeine intake, physical activity, and body mass index on cardiovascular disease mortality in older adults. In
women, alcohol consumption (less than or equal to 3 drinks per day) was related to a 15-30% decreased risk in
those less than 80 years old. In men, 4+ drinks per day was associated with a 15-30% reduced risk. Both
underweight and obese women and smokers were at increased risk. Moderate alcohol consumption, physical
activity and normal weight are important health promoters in our aging population.

American Heart Association Meeting Chicago (November 2010) New research from the Nurses’ Health
Study suggested that women can safely have a drink or two at middle age and those that do survive more
successfully to old age, compared with nondrinkers. Previously, the American Heart Association and Federal
Dietary Guidelines recommended women restrict their drinking to one standard drink a day. The study also
found that women drinking most days of the week were healthier than those who drank only one or two days a
week. A second study analyzed the risk of stroke in 73,450 women in the Nurses’ Health Study and found that
women who had a daily drink had a 20% lower risk of stroke compared to nondrinkers. Women on hormonereplacement
therapy and had two drinks a day had an increased risk of stroke. A third study presented at the
meeting by researchers at the University of Rome found that male heart-bypass-surgery patients who drank
two to three drinks daily had a 25% reduction in the rate of subsequent cardiovascular complications like heart
attacks and strokes compared to nondrinkers. The risk of dying increased if patients imbibed four or more
drinks daily and had a left ventricle heart problem. The benefit in woman after bypass surgery was smaller. A
fourth study by cardiologist Dr. Michelle Albert found that female workers with stressful jobs were more likely
than women with less job strain to suffer a heart attack or stroke or to have clogged arteries. The high-stress
group of women had a 40% greater overall risk of heart problems.

Alcohol consumption and mortality in patients with cardiovascular disease J of Amer Coll of Cardiology
(January 2010) A study from Italy reviewed fifty-four publications and accepted eight for analysis. Among
patients that had had a cardiovascular event, they found that light to moderate drinking (5 to 25 g/day) was
significantly associated with a lower incidence of cardiovascular and all-cause mortality. The meta-analysis on
cardiovascular mortality confirmed the J-shaped curve with a significant maximal protection (average 22%) by
alcohol at approximately 26 g/day. They emphasized that the benefit was most evident in those who drank
regularly throughout the week. The researchers claimed that it was alcohol, and not polyphenols, that was the
preventive agent.

Drinking alcohol temporarily heightens stroke risk Stroke (July 15, 2010 online) Results from the Stroke
Onset Study show double the risk for ischemic stroke an hour after consuming as little as a single drink of
wine, beer or liquor. Previous studies have linked moderate alcohol intake to a decreased risk of stroke.
Heavy drinking is associated with an increased risk for ischemic stroke. Critics of this study point to its small
population size and the fact that participants may have had other unrecognized risk factors. If this temporary
increased risk is present, it would be outweighed by the long term health benefits of moderate alcohol
consumption.

Wine may help with slow heart rates Harvard Heart Letter (April 2010) Bradycardia (a heart rate of less
than 60 beats per minute) may be helped by a glass or two of wine, since alcohol in moderate amounts speeds
up the heart rate.

The association between alcohol consumption and mortality: the Swedish women’s lifestyle and health
study Eur J Epidemiol (January 2011) Women ages 30-49 years were studied. Compared with non-drinking,
light to moderate drinking showed a statistically significant inverse association with total mortality. The results
suggest that in younger women, a possibly beneficial effect of light to moderate drinking on future risk of
mortality is limited to a prevention of cardiovascular disease mortality but not cancer mortality.

Is alcohol beneficial or harmful for cardioprotection Genes Nutr (Ahead of print) The enzyme
paraoxonase1 (PON1) can inhibit LDL oxidation and/or inactivate OxLDL. Therefore, PON1 plays a central
role in the disposal of OxLDL and thus is antiatherogenic (prevents atherosclerosis). Moderate alcohol
regulates liver PON1 gene expression and serum activity, whereas heavy alcohol consumption had the
opposite effects in both animal models and in humans. Red wine also has polyphenols such as quercetin and
resveratrol that are also known to have cardioprotective effects. The authors have shown that quercetin also
up regulates PON1 gene in rats and human liver cells. Both moderate ethanol and quercetin, the two major
components of red wine, exhibit cardioprotective properties via the up-regulation of the antiatherogenic gene
PON1.

Moderate wine consumption is associated with better cognitive test results: a 7 year follow up of 5033
subjects in the Tromso Study Acta Neurol Scand Suppl (2010) Moderate wine consumption was
independently associated with better performance on all cognitive tests in both men and women. There was no
consistent association between consumption of beer and spirits and cognitive test results. Alcohol abstention
was associated with lower cognitive performance in women.

Moderate drinking linked to lower risk of Alzheimer’s disease J of Alzheimer’s Dis (May 2010) A Spanish
study suggests a protective effect of alcohol consumption, especially in non smokers. Smoking had no effect
on Alzheimer’s risk, but moderate drinking seemed to reduce the risk for the disease. However, women in the
study who smoked, but didn’t drink, had no greater risk of Alzheimer’s disease than women who abstained
from both. The interactions between smoking and alcohol consumption need to be clarified.

Skeletal

Association between alcohol consumption and bone strength in Korean adults: the Korean Genomic
Rural Cohort Study Metabolism (March 2010) A growing body of research has shown that chronic
alcoholism leads to osteopenia and increased incidence of skeletal fractures, but some studies have concluded
that alcohol consumption may be associated with higher bone mineral density in elderly populations. This
study investigated the association of alcohol consumption and bone strength in Korean adults. The association
between alcohol consumption and risk of reduced bone strength showed a J-shaped curve for both Korean
men and women.

Alcohol consumption is inversely associated with risk and severity of rheumatoid arthritis
Rheumatology (November 2010) This study from the UK looked at the association between frequency of
alcohol consumption and the risk and severity of rheumatoid arthritis (RA). There were some limitations to the
study (they did not look at the exact amount people drank), but the data suggested that regular alcohol
consumption decreased the risk of developing rheumatoid arthritis and reduced the symptoms of those who
have already developed it. Nondrinkers were four times more like to develop RA than people who drank
alcohol on more than 10 days a month. No difference among the different types of alcoholic beverages was
determined.

Metabolic

Mediterranean diet and red wine protect against oxidative damage in young volunteers Atherosclerosis
(August 2010) This study assessed the effect on oxidative damage of the administration of a Mediterranean
diet (MD) compared with an Occidental diet (OD) in young adult volunteers with or without the concomitant
intake of red wine. Volunteers on MD showed better antioxidant defenses and less oxidative damage than
those on OD. Moderate wine consumption improved antioxidant defenses in both groups and counteracted the
oxidative damage observed with OD.

Coffee, tea and alcohol intake in relation to risk of type 2 diabetes in African American women Am J Clin
Nutr (October 2010) The results suggest that African American women who drink moderate amounts of
caffeinated coffee or alcohol have a reduced risk of type 2 diabetes.

Alcohol consumption, weight gain, and risk of becoming overweight in middle-aged and older women
Archives of Internal Medicine (March 2010) A prospective cohort study showed that initially normal-weight
women who consumed a light to moderate amount of alcohol gained less weight than their abstaining
counterparts and had a lower risk of becoming overweight and/or obese during 12.9 years of follow-up. The
best drink for keeping pounds off was red wine. The authors cautioned against making recommendations on
alcohol use as a tool against obesity, given the potential medical and psycho-social problems associated with
alcohol abuse.

Type of alcoholic beverage and incidence of overweight/obesity in a Mediterranean cohort: The SUN
project. Nutrition (December 2010) The SUN project in Spain followed drinkers for six years. Beer and spirits
consumption was associated with a higher yearly weight gain after adjusting for relevant confounders and was
also associated with a higher risk of developing overweight/obesity compared with nondrinkers. No association
between wine consumption and yearly weight change or the risk of developing overweight/obesity was
apparent.

Effect of body mass index (BMI) and alcohol consumption on liver disease: analysis of data from two
prospective cohort studies Brit Med J (April 2010) Increased BMI (obesity) and alcohol consumption are
both related to liver disease, and there is evidence of a supra-additive interaction between the two.

Cancer

Alcohol consumption and prostate cancer: a mini review Exp Oncol (July 2010) The etiology of prostate
cancer remains largely unknown. The high consumption of meat, alcohol and dairy products has been linked
to a greater risk.

Red wine consumption not associated with reduced risk of colorectal cancer Nutr Cancer (August 2010)
Red wine polyphenol antioxidants inhibit colorectal cancer development in animal studies. This prospective,
multiethnic cohort of middle-aged men were part of the California Men’s Health Study and were members of
Kaiser Permanente California Health Plans. Moderate red wine consumption was not associated with reduced
risk of colorectal cancer in this population of middle-aged men.

Resveratrol and resveratrol analogues - structure-activity relationship Pharm Res (June 2010) A number
of analogues have been synthesized to improve the beneficial effects of resveratrol. Striking in vivo effects can
be observed with hexahydroxystilbene (M8), the most effective synthetic analogue of resveratrol. The authors
showed that M8 inhibits tumor as well as metastasis growth of human melanoma in two different animal
models.

Alcohol consumption and cancer risk: understanding possible causal mechanisms for breast and
colorectal cancers. Evidence Report No. 11-E003 Agency for Healthcare Research and Quality (November
2010). Many potential mechanisms by which alcohol may influence the development of breast or colorectal
cancers have been explored but the exact connection or connections remain unclear. The evidence points in
several directions but the importance of any one mechanism is not apparent at this time.

Breast-Healthy lifestyle worthwhile J of Breast Ca Research (October 2010 online) Data from the Women’s
Health Initiative Observational Study that began in 1993 including women ages 50 to 79 indicated that women
who had regular physical activity (20 minutes of vigorous exercise at least five days a week), maintained a
healthy weight, and drank less alcohol (no more than one alcoholic beverage a day) had a lower breast cancer
risk with, and without a family history of the disease.

Drinking not a risk factor for the most common form of breast cancer J of National Ca Inst (August 2010
online) Data from the Women’s Health Initiative tracked from 1993 to 2005 found that women who consumed
seven or more drinks per week suffered a higher risk (double) of lobular carcinoma compared to abstainers but
did not have a higher risk of the more common form of breast cancer known as ductal carcinoma (70% of all
breast cancer cases).

Alcohol consumption and the risk of breast cancer among BRCA1 and BRCA2 mutation carriers Breast
(December 2010) BRCA1 and BRCA2 are two gene mutations that increase the risk of breast and ovarian
cancer in women. A study of 54 medical centers in eight countries found that exclusive consumption of wine
was associated with a significant reduction in the risk of breast cancer among women with BRCA1. The
authors of the study conclude that alcohol consumption does not appear to increase cancer risk in women
carrying a BRCA gene mutation.

Alcohol consumption and breast cancer recurrence and survival among women with early-stage breast
cancer: the life after cancer epidemiology study J Clin Oncol (October 2010) This study looked at breast
cancer survivors and their lifestyle. Consumption of more than two drinks per day increased the risk of
recurrence by 39%, particularly among postmenopausal and overweight/obese women. It is theorized that
alcohol increases circulating levels of estrogen and this may cause recurrence of the cancer. Most women in
the study were wine drinkers. Alcohol intake was possibly associated with decreased risk of non-breast cancer
death.

Pregnancy

Effect of alcohol consumption on in vitro fertilization Obstet Gynecol (January 2011) Consumption of as
few as four alcoholic drinks per week is associated with a decrease in in vitro fertilization live birth rate.

Light drinking during pregnancy: still no increased risk for socioemotional difficulties or cognitive
deficits at 5 years of age? J of Epidemiol & Comm Health (October 2010) Results from University College
London Millennium Cohort Study found that 5-year-old children born to mothers who drank up to 1-2 drinks per
week or per occasion during pregnancy were not at increased risk of clinically relevant behavioral difficulties or
cognitive defects compared with children of mothers in the not-in-pregnancy group. Children born to light
drinkers were 30% less likely to have behavioral problems than children whose mothers did not drink during
pregnancy. Children born to mothers who drank heavily or binged were more likely to show hyperactivity and
conduct and emotional problems compared with mothers who did not drink during pregnancy. The study’s
authors said that responsible drinking while pregnant does not put a child at long-term risk, but did not make an
advocacy stance. (Note: The American Pregnancy Association says there is no safe amount to drink during
pregnancy, and the more an expectant mother drinks, the more she raises her baby’s chances of having
problems).

Alcohol in pregnancy may boost child’s leukemia Cancer Epidem, Biomark & Prevent (May 2010)
Researchers looked at 21 previous studies of women’s drinking habits during pregnancy and childhood
leukemia, and found that women who drank during pregnancy had a 56% increased risk of childhood acute
myeloid leukemia (AML). The caveat is that childhood AML is rare and may have many causes. The vast
majority of women who consume alcohol during pregnancy will not have a child who develops leukemia, but
given the risks associated with drinking during pregnancy, these results reinforce the notion that abstaining
from alcohol during pregnancy or in women planning to get pregnant is advisable.

Miscellaneous

Alcohol intake and risk of incident psoriasis in US women: a prospective study Arch Dermatol
(December 2010) Non light beer intake in a prospective study of female nurses was associated with an
increased risk of developing psoriasis. Other alcoholic beverages did not increase the risk of psoriasis in the
study.

Testing the validity of the Danish urban myth that alcohol can be absorbed through feet: open labelled
self experimental study Journal BMJ (December 2010) The authors debunked an old Danish myth that it is
possible to get drunk by immersing your feet in alcohol. They concluded that driving a vehicle or skippering a
boat with boots full of vodka seems to be safe and that brewery workers cannot become intoxicated by falling
into a brewery vat. Feet are impenetrable to the alcohol component of vodka.

FDA tells drink makers not to mix caffeine and alcohol Los Angeles Times (November 18, 2010) Energydrink
makers have been warned by government regulators that the combination of caffeine and malt alcohol in
beverages is unsafe and do not meet the FDA’s standards for safety. Some of the drinks (Four Loko, Joose,
Moonshot) have the same alcohol as four or five beers and the caffeine equivalent of three to four cups of
coffee. The caffeine and other stimulants in the drinks produce a “wide-awake drunk.” Several states including
Michigan have banned the drinks. The producer of Four Loko drinks agreed to remove caffeine, guarana and
taurine from their product. The FDA is expected to ban these drinks completely.

Health behaviors of adults: United States 2005-2007 Centers for Disease Control & Prevention (March
2010) 6 in 10 American adults were regular drinkers in 2005-2007. Men are more likely than women to be
drinkers (68% versus 55%) and women were more likely than men to abstain from alcohol (31% versus 18%).
White people were more likely to be drinkers. The more educated people were, the more likely they were to
drink. 74% of people interviewed who have a graduate degree were drinkers, compared to 44% of people with
a high school diploma.

Possible cure for alcohol intolerance mutation Nature Structural and Molecular Bio (January 10, 2010
online) There are at least one billion people worldwide, mainly East Asians, who have alcohol intolerance due
to an inactive enzyme (aldehyde dehydrogenase 2 or ALDH2) needed to metabolize alcohol. If people with this
mutation drink alcohol, they develop a flushing of the face, nausea, and an increased heart rate. They are also
at risk for certain cancers. Researchers at the National Institute on Alcohol Abuse and Alcoholism have
discovered a molecule (Alda-1) that can reactivate the defective enzyme in the presence of alcohol. Potentially,
this could be developed into a treatment that would allow those with the inactive ALDH2 enzyme to drink
alcohol without the side effects. Alda-1 may also have use as a hangover treatment since hangovers are in
part due to the buildup of aldehyde. Alda-1 may have a therapeutic role in heart attacks as well, since ALDH2
can neutralize toxins and lessen damage to heart tissue and Alda-1 can enhance its activity.

Resveratrol Update

Boosting resveratrol in white wines Wines & Vines (December 2010) Dr. Oliver Yu and his team at St. Luis
Community College’s Donald Danforth Plant Science Center have developed experimental yeast that can
make resveratrol. The practical application of this discovery is the possibility of increasing the resveratrol
content of white wine, a preferred drink by many which is very low in polyphenolic content.

Dose-dependency of reservatrol in providing health benefits Dose Response (March 2010) A review. At
lower dose, resveratrol can be useful for maintaining human health including cardioprotection, inhibition of LDL,
hindering of platelet aggregation and promotion of anti-inflammatory effects. At higher dose, resveratrol can kill
tumor cells.

Polyphenols from red wine are potent modulators of innate and adaptive immune responsiveness Proc
Nutr Soc (August 2010) According to current literature and the work of these researchers, moderate
consumption of red wine seems to be protective for the host in the prevention of several diseases, even
including age related diseases from its immunomodulating properties.

Resveratrol, sirtuins, and the promise of a DR mimetic Mech Ageing Dev (April 2010) Dietary restriction
(DR) delays or prevents age related diseases and extends lifespan in species ranging from yeast to primates.
The sirtuin activator resveratrol has been proposed as a candidate DR mimetic. Resveratrol extends lifespan
in yeasts, worms, flies and short-lived species of fish. In rodents, extension of normal lifespan has not been
observed.

Reservatrol regulates pathologic angiogenesis by a eukaryotic elongation factor-2 kinase-regulated
pathway Amer J of Pathology (July 2010) Vision researchers at Washington University School of Medicine in
St. Louis found that resveratrol can block the formation of new blood vessels (angiogenesis) as well as
eliminate blood vessels that already have begun to develop in the macula of mice. The doses used were
considerably more than than found in several bottles of wine. The research opens the possibility of resveratrol
as a future treatment for abnormal blood vessels seen in age related macular degeneration, diabetic
retinopathy and retinopathy of prematurity, all of which are prevalent eye diseases.

Resveratrol aids stem cells in repairing heart damage J of Cell and Molecular Med (August 2010 online)
Stem cells were able to more successfully heal heart damage in rats when they were in the presence of
resveratrol and the stem cells survived longer with resveratrol treatment.

As Valentine’s Day approaches, a few words about chocolate and its health benefits are pertinent. As reported
in a number of sources, and in the Los Angeles Times (“Sweet Indulgences,” February 21, 2010), chocolate,
like alcohol, taken in moderation has been shown to be good for you. Dark chocolate is clearly the most
beneficial form of chocolate since it is flavonoid-rich. Studies have shown that 4 tablespoons of ground cocoa
a day give a maximum benefit. Other research indicates that as little as 6.7 grams of dark chocolate a week
(equal to three small squares) can be beneficial. To obtain the most benefit from chocolate in candy form, look
to dark chocolate with at least 70% or more cocoa solids. Chocolate is not effective when applied in topical
form.