If you have a good moveset for Mewtwo, post an answer below and upvote the best ones. Remember, this is for competitive movesets, not in-game. Ability, EVs etc should be included, and we encourage sets for VGC doubles as well as singles. Make sure to read all the guidelines here.

Sorry but this is quiet an old question and quite an old answer. Please do not reply or comment on very dol questions/answers as it clogs the place up. You may still answer this question though, since it is a moveset Q

This provides Super-Effective coverage against almost anything you'd face in Ubers. Shadow Ball deals with all the Psychics, as well as Chandelure. Thunder takes down the Flying types of Uber, as well as Kyogre. Ice Beam also deals with the Flying types of Uber, all the Dragon types, and Groudon. Aura Sphere takes down Dialga and Darkrai. The only common Ubers who won't be hit for super-effective damage are Jirachi, some random Arceus types, and Palkia. However, you'll be able to do enough damage to these Pokemon with a neutral hit off of Mewtwo's Choice Spec boosted Special Attack. Your EVs are sweeping EVs.

Ever notice that great 110 Attack, probably not as Mewtwo has the second highest S.Attack in the game(154), but his Attack is still great. Bulk-up is boosting. Ice-punch is coverage. Fire-punch/Thunder-punch choose coverage. Earthquake/Drain-punch more powerful coverage or weaker coverage and healing.

Having a Psychic type, let alone the strongest Psychic type in the game, that doesn't know a single Psychic move? No thank you. The only time I'd bother with a physical move for Mewtwo is Brick Break and only until I learn Aura Sphere.

Not to mention, that Mewtwo's special attack is 40% higher. And since Flamethrower/Thunderbolt/Ice beam are all 26.6% stronger than their punch counterparts, they'd be 77.3% stronger when used by a Mewtwo (assuming no EVs or nature affecting attack or special attack).

There is a reason why Mewtwo is the fourth most powerful Pokemon (after Kyogre, Arceus, and Lugia). Mewtwo is simply amazing. Psystrike is incredibly powerful STAB. Blizzard hits multiple foes. Aura Sphere can hit any foe in a Triple Battle. And Charge Beam can be used to finish off (which is actually a large amount of health remaining for some Pokemon, 407 Life Orb boosted Special Attack after all) a foe and possibly gain a Special Attack boost. Which means the end of all life as we know it.

[email protected](X) 252Atk/252Spe/4hp
-Psycho Cut/Zen HeadButt
-Power up punch/Brick Break
-Recover(filler)
-Me First
My problem you see is I got an ADAMANT mewtwo -_- so I had no other option but this...Also I have a hard time finding Tms in X so flips Desk. Anyway psychocut is stab cool crit hax. Zen is flinch hax plus more power. Brick break kills screens setup and is stab once megavolved. Power up is ok because mewtwo is a bit bulky. Recover is a personal fave but W-o-W works good for bulk n so does Bulk up. Me First is good because mewtwo is fast and things carrying a super effective Atk on m2 will be surprised when they get killed by their own shadow ball or outrage(Dragon atk vs me first= fail). #forgottosoftreset

Psystrike is a little bit better than Psychic with STAB but Psychic maybe decreases the oppenent's Sp. Def.
Aura Sphere for type coverage .This attack never misses!
Shadow Ball again for coverage and may decrease opponent's Special Defense .That's why I don't recommend Psychic in this Pokemon.Calm Mind increases Sp.Atk. and Sp.Def .
Flamethrower and Ice Beam for more type coverage !

True Unbreakable. But while Elektross and Spiritomb can be very troublesome oppenents, Elektross' pre-evolution froms aren't very difficult and Sableye's stats are bad enough that an advantage is hardly necessary.

Suicide Lead Mewtwo

Simple. Mewtwo leads off with a very fast Taunt, one of the fastest in the game, then proceeds to set up. Darkrai can't Void after the Taunt, and Mewtwo can SelfDestruct out so that other teammates can abuse its screens before they wear off.

I hope this quote inspired you to give your Mewtwo a great moveset as much as it did me.

Okay, so I have 3 seperate movesets: two for each Mega Evo and one if you're playing in Gen 5 or earlier.

Mega Mewtwo X @ Mewtwonite X
EVs: 252 Atk / 252 Spd / 4 HP

Brick Break
Psycho-Cut
Earthquake
Poison Jab

The first two are STAB moves that have good coverage by themselves. Earthquake has great power and coverage, and Poison Jab just became great for killing Fairies.

Mega Mewtwo Y @ Mewtwonite Y
EVs: 252 Sp. Atk / 160 Spd / 100 HP

Psystrike
Aura Sphere
Ice Beam
Thunderbolt

Psystrike is a STAB move that does physical damage (nice since Pokémon that are weak to Psychic often have good Sp. Defense). Aura Sphere is good for Dark-types, as well as many others. And of course, Mewtwo gets the BoltBeam combo.

Mewtwo @ Expert Belt
EVs: 252 Sp. Atk / 252 Spd / 4 HP

Psystrike
Aura Sphere
Ice Beam
Thunderbolt

Since both Mewtwo and Mega Mewtwo Y are special attackers, they have the same moveset. Note that the held item and EVs are different, though.

So there you go. Mewtwo is a great competitive Pokémon, as its Mega form is the most powerful in the entire game. I hope you liked it, and if you did or have anything to say, feel free to leave a vote/comment.

Mewtwo @ Either Mewtwonite X or Mewtwonite Y
Timid Nature (-Atk, +Spd)
Characteristic: Proud of its Power (So its Attack stat will be at balance)__
Mewtwo Mega X version

Psychic - STAB, it still has high Special attack, I don't mind.
Drain Punch/ Focus Punch: They get STAB due to Mega Mewtwo X being part Fighing Type.
Double Team/ Shadow Ball: Ignores moves so Focus Punch can be used easier/ Covers Ghost weakness.
Stone Edge- Once Mega-Evolved, it can cover its Flying type weakness. Also a decent chance to Critical.__
Mewtwo Mega Y version

Calm Mind - It raises its Already-good Special Attack, as well as being a Special wall to annoy Strong Special attackers such as Abomasnow and Archeops.
Psychic - STAB, fits with high Special Attack, and does amazing 90-power damage.
Aura Sphere - Covers its Dark weakness, and it never misses.
Shadow Ball - It covers its Ghost weakness, and it does amazing damage.__

Bulk Up boosts Attack and Defence by one stage.
Drain Punch is STAB and recovers health. Low Kick is the alternative option as many Pokemon in the Uber tier weigh alot. Hits Rock, Steel, Normal, Dark and Ice types.
Zen Headbutt is the second STAB move and hits hard and can flinch. Psycho Cut is a slightly weaker option that has a high crit ratio and is more accurate. Hits Fighting and Poison types.
Stone Edge or Rock Slide are used to hit Flying types, mainly Ho-Oh and Lugia. Poison Jab is solely for hitting Fairy types hard. Ice Beam can be used to hit Dragon, Ground and some Flying types harder than the other moves.

Psystrike is STAB and hits incredibly hard, especially on Pokemon that have a low physical defence stat. Hits Fighting and Poison types.
Focus Blast is for coverage and hits very hard. Aura Sphere is the weaker option but it never misses. Hits Steel, Normal, Dark, Rock and Ice types.
Ice Beam has great coverage alongside the two mentioned moves above and provides important coverage. Hits Dragon, Grass, Flying and Ground types.
Calm Mind is to boost its already high Special Attack and Special Defence to even higher levels. Shadow Ball can be used over it to hit Ghost and Psychic types. Recover is an option to restore health as Mega Mewtwo Y does force a lot of switches.