Summariesfor LRRK2 gene

This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat

region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a

MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the

mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson disease-8. (provided by

RefSeq, Jul 2008)

GeneCards Summary for LRRK2 Gene:

LRRK2 (leucine-rich repeat kinase 2) is a protein-coding gene. Diseases associated with LRRK2 include parkinson disease 8, and lrrk2-related parkinson disease. GO annotations related to this gene include GTP binding and protein homodimerization activity. An important paralog of this gene is LRRK1.