The name 'Ampthill' is of Anglo-Saxon origin. The first settlement was called 'Aemethyll', which literally means either 'ant-heap' or 'ant infested hill'. In the Domesday Book, Ampthill is referred to as 'Ammetelle', with the landholder in 1086 being Nigel de la Vast. The actual entry reads: Ammetelle: Nigel de la Vast from Nigel d'Aubigny. A further variation may be 'Hampthull', in 1381.[2]

In 1242, King Henry III confirmed the right to hold a market on Thursdays. These continue more than 750 years later.

Henry VIII was a frequent visitor to Ampthill Castle, and it was there that Catherine of Aragon lived from 1531 until divorced in 1533, when she was moved to Kimbolton. The castle was built in the 15C by Sir John Cornwall, later Lord Fanhope, from ransoms after the Battle of Agincourt. Although the Castle is now gone, some intriguing indications of castle life remain- such as the local ponds (Westminster pond being one) allegedly built to supply the castle with regular supplies of fish.

The church of St Andrew ranges in date from Early English to Perpendicular. It contains a monument to Richard Nicolls (1624–1672), an Ampthill native, who, under the patronage of the Duke of York, brother to Charles II, to whom the king had granted the Dutch North American colony of New Netherland, received the submission of its chief town, New Amsterdam, in 1664, and became its first English governor, the town taking the name of New York.[3] Nicolls perished in the action between the English and Dutch fleets at Solebay, and the ball which killed him is preserved on his tomb. The church also contains a ring of eight bells. There were six until 1981, when the two new bells were installed. Services Run weekly, with Sung Eucharist at 9.30AM and Evensong at 6.30PM. The church has a regular 4 part choir, which has sung morning and evening services for over 100 years.

Houghton House was built in 1621 by Mary, Countess of Pembroke and sister of the poet Sir Philip Sidney. In 1675, the house may have provided the inspiration for 'House Beautiful' in John Bunyan's The Pilgrim's Progress. It is thought that Bunyan's work is loosely based on his own journey between Bedford and Luton, and the steep slope leading into Ampthill could have been the model for the 'Hill of Difficulty'. Houghton House passed to the Duke of Bedford in 1738 and became a ruin after the removal of the roof in 1794.

Notable 20th-century architect Sir Albert Richardson lived in Ampthill from 1919 until his death in 1964 at Avenue House, 20 Church Street. Among his last projects was the building that housed Mid Bedfordshire District Council (formerly the Ampthill Rural District Council offices) until August 2006, at 12 Dunstable Street (1963–1965).

Ampthill still trades on its "historic market town" reputation, serving as a commercial centre for surrounding villages. The town has several lively pubs, a wide variety of restaurants, a Waitrose supermarket and a selection of small independent specialist shops below flats. A number of small businesses such as solicitors, estate agents, financial services, hairdressers, music schools and a bookshop are also located in town, with larger businesses to be found on the commercial and industrial developments on the outskirts, along the town's bypass. Ampthill also has a high concentration of public amenities, including schools, doctors surgeries, a fire and ambulance station, and a police station.

Ampthill's historic centre, coupled with well-respected[according to whom?] schools and the facilities mentioned above has made it one of the most expensive places to buy a house in Bedfordshire, even in comparison with other mid-Bedfordshire towns such as neighbouring Flitwick, and Cranfield. In a survey,[4] it was found that the majority of Ampthill's workers are employed locally, with around 20% working in Ampthill itself, and most of the remainder travelling to nearby centres of employment such as Bedford, Luton and Milton Keynes. Around 13% of workers commute from Ampthill to London daily. The survey also found that the turnover of residents was low, most having been in Ampthill for well over a decade.

Recent years have witnessed substantial development in Ampthill and the surrounding area. The Bedford Street area was substantially redeveloped in 2006/2007, with the demolition of a Shell petrol station, shopping arcade and small Budgens supermarket, to make way for a new Waitrose supermarket, an improved town car park and a development of shops and apartments known as Oxlet House. The supermarket opened on 29 September 2006, with Oxlet house being completed in late 2007.

This article's list of residents may not follow Wikipedia's verifiability or notability policies. Please improve this article by removing names that do not have independent reliable sources cited within this article showing they are notable and residents or by incorporating the relevant publications into the body of the article through appropriate citations.(December 2013)