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World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar. Best Paper Award : Dr. Muhammad Baqir MR Fakhrildin
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Abstract

Emergence of antibiotics resistance bacteria is a persistent global
problem affecting public health. The occurrence and widespread
resistance to carbapenems among environmental bacterial isolates can
constitute a major threat to chemotherapy. This investigation was
carried out to assess the antibiotics susceptibility profile of imipenem
resistant bacterial isolates from Great Kwa river located in Calabar,
Nigeria. From different sites of the Great Kwa River, a total of 89
bacterial isolates were screened for imipenem resistance and
susceptibility to 13 antibiotics. Out of the 89 isolates, 20(27.37%) were
imipenem resistant, 22(23.16%) showed intermediate resistance while
47(49.47%) were susceptible to imipenem. The resistant and intermediate resistant isolates
were of the following genera: Serratia spp (29%), Plesiomonas spp (17%), Aeromonas spp
(14%), Acintebacter spp (2%), Providencia spp (2%), Citrobacter spp (5%), Klebsiella spp
(5%), Escherichia spp (5%), Proteus spp (11%), Salomnella spp (5%). Among the resistant
and intermediate resistant isolates, the percentages that were resistant to the 13 antibiotics
were: Orfloxacin (57%), Pefloxacin (21%), Gentamycin (24%), Augmentin (48%),
Ampicillin (24%), Ciprofloxacin (14%), Streptomycin (12%), Chloramphenicol (29%),
Septrin (33%), Sulfamethoxazole-trimethoprim (29%), Aztreonam (64%), Ceftazidime (76%)
and Cefuroxime (38%). Imipenem resistant bacteria are emerging globally at a rapid rate. The
resistance can be transferred to human commensals and pathogens and can constitute a threat
to an effective therapy using imipenem.