Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Additionally we are shipping VPS33A Antibodies (11) and VPS33A Proteins (4) and many more products for this protein.

VPS33A is mutated in Hermansky-Pudlak syndrome and may have a role in melanogenesis

These studies suggest that loss of Purkinje neurons is the most obvious neurological atrophy in the buff mutant mouse, a structural change that generates motor coordination deficits and impaired postural phenotypes.

VPS33A Antigen Profile

Antigen Summary

Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene is a member of the Sec-1 domain family, and it encodes a protein similar to the yeast class C Vps33 protein. The mammalian class C VPS proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway.