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This is considered as the easiest level in the entire game, as some key risk factors are already evolved from the start, giving the player a huge advantage, mostly from the "Smoker" risk factor (Unlocks Brain Aneurysm, Lung Cancer, Emphysema, etc.). This level serves as an introduction to Bio Inc.

This is the second stage, so the difficulty begins to increase. On this stage, Stress is already evolved, and the nervous system starts at 81.5%, which means the patient will go to the doctor sooner. You should save Bio Points at first, buy Hypertension and High Cholesterol, then save until you get 49 or 50 Bio Points to gain Angina, Arrhythmia and Heart Attack. Victim will get a Heart Attack before he gets a chance to go to the doctor or about 90% of circulatory.

In this stage, traits mutate at a higher rate, disease costs increase, and risk factor costs decrease, which tempts you to evolve risk factors that increase the damage that diseases do, while letting diseases evolve mostly by themselves.