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The rising incidence and poor prognosis of esophageal adenocarcinoma in the Western world have intensified research efforts into earlier methods of detection of this disease and its relationship to Barrett's esophagus. The progression of Barrett's esophagus to adenocarcinoma has been the focus of particular scrutiny, and a number of potential tissue and… (More)

This study examined the association between 17p allelic loss, p53 gene mutation, p53 protein expression and DNA aneuploidy in a series of adenocarcinomas arising in the oesophagus and gastric cardia. 17p allelic loss was detected in 79% (15 of 19) of oesophageal and in 83% (29 of 35) of gastric adenocarcinomas. p53 mutations were detected in 70% (14 of 20)… (More)

Treatment adherence and health outcomes in patients with bronchiectasis infected with Pseudomonas aeruginosa: a one-year prospective study. Cardiac arrest outcomes after therapeutic hypothermia: experience in a district general hospital with no interventional cardiology services. Poster 2 Findings of a regional neurology referrals audit. No association… (More)

Introduction: The incidence of oesophageal adenocarcinoma (OAC) has increased dramatically over recent years and Barrett's oesophagus (BO) is the most established risk factor for its development. Endoscopic surveillance of BO has been widely advocated but hinges on assessment of repeated endoscopic biopsies, which is problematic. The use of biomarkers… (More)