With the aim of characterizing the active site of the neutral endopeptidase [EC 3.4.24.11 (NEP)] and especially its putative S1 subsite, two series of new thiol inhibitors designed to interact with… (More)

The incorporation of a Freidinger-like lactam structure into the backbone of peptides has been proven to be an useful strategy in the design of a variety of conformationally restricted targets.… (More)

Several peptides play an important role in physiological and pathological conditions into the cardiovascular system. In addition to well-known vasoactive agents such as angiotensin II, endothelin,… (More)

A new solution-phase methodology microwave-assisted for improving the Pictet–Spengler reaction in the synthesis of the tetrahydroisoquinoline and β-carboline derivatives has been reported. This… (More)