Compounds with >50% inhibition at 10 uM concentration are defines as active. Activity ScoringActivity scoring rules developed at Sanford-Burnham Center for Chemical Genomics were devised to take into consideration different information available from screening, and in this case include compound potency, the screening stage of the data and compound behavior in the assay. Details of the Scoring System will be published elsewhere. Briefly, the outline of the scoring system utilized for the Luciferase assay is as follows: 1) First tier (0-40 range) is reserved for primary screening data. The score is correlated with % displacement in the assay demonstrated by a compound at 10 uM concentration:a. If primary % inhibition is less than 0%, then the assigned score is 0b. If primary % inhibition is greater than 100%, then the assigned score is 40c. If primary % inhibition is between 0% and 100%, then the calculated score is (% Inhibition)*0.42) Second tier (41-80 range) is reserved for dose-response confirmation data and their analogues and is not applicable in this assay.3) Third tier (81-100 range) is reserved for resynthesized confirmed positives and their analogues and is not applicable in this assay.