Diabetes mellitus is becoming a global epidemic. There is a need to devise a non invasive method for detection of diabetes and its related complication. Tear proteins are easy to collect causing no harm to a patient and different studies indicate that tear proteins of diabetic patients are significantly different from non diabetic population. This difference in the composition of tear proteins become more pronounced with advancement of diabetic retinopathy.

Diabetic population with no retinopathy or Mild non proliferative diabetic retinopathy

Grade 2

Moderate non proliferative diabetic retinopathy

Grade 3

Severe non proliferative diabetic retinopathy

Grade 4

Proliferative diabetic retinopathy and advanced diabetic eye disease

Detailed Description:

Diabetes mellitus causes a significant alteration in tear proteins. If we analyze tear proteins by means of electrophoresis, HPLC, and mass spectroscopy.

We can find different type of tear proteins in different grades of diabetic retinopathy these biomarkers can help in mass screening , diagnosis and management of diabetic population.

Eligibility

Ages Eligible for Study:

30 Years to 90 Years (Adult, Senior)

Genders Eligible for Study:

Both

Accepts Healthy Volunteers:

Yes

Sampling Method:

Non-Probability Sample

Study Population

diabetic population

Criteria

Inclusion Criteria:

diabetic patients with type 2 diabetes

age above 30

willing to participate

Exclusion Criteria:

ocular surface disorders.

collagen vascular diseases

Limbal hyperemia

previous ocular surgery

creatinine level above 1.0

liver diseases

Contacts and Locations

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For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00698698