Department / University Information

Biography

Dr. Gentile is a recognized expert in the transglutaminase research area and has a strong background in the molecular biology and biochemical aspects of the transglutaminase (TG) enzymes expression, activity and function. His work has been focused to the tTG (TG2) characterization in normal and pathological cellular events (cell growth and differentiation, adhesion, apoptosis, neurodegeneration) by biochemical and molecular biology studies. Currently dr. Gentile is a Researcher at the University of Campania “Luigi Vanvitelli” .

Research Interest

-Studies on cerebral polyamine metabolism.-Studies on polyamine binding to synaptosomal membranes of rat brain.-Studies on structural modifications of a major protein secreted from the rat seminal vesicle by transglutaminase-Studies of transglutaminase-mediated modifications of the rat sperm surface.-Studies on human semen tranglutaminase.-Characterisation of rat intestinal transglutaminase and studies on transglutaminase-mediated modifications of gliadins in relation to the Coeliac Disease.-Cloning and characterisation of the gene for human tissue transglutaminase.-Transfection of the human tissue transglutaminase cDNA in Balb-C 3T3 mouse fibroblasts: molecular and cellular characterisation of the stable transfected cell lines.-Site direct mutagenesis of the human tissue transglutaminase cDNA.-Expression and characterisation of the secretory transglutaminase from human prostate.-Characterization of the human tissue transglutaminase as a mediator of the cell signal transduction pathway.-Studies on the possible involvement of transglutaminases in the pathogenesis of neurodegenerative diseases.

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