The series started airing on May 2007, and was filmed in Mexico City under the direction of producers Rodolfo de Anda and Alexis Ayala. It aired its third and final season Mondays on Canal 5 at 10:00pm and on cable TV channel Galavisión Tuesdays at 21:30pm.

The character of El Pantera was created in the 1970s by the writer Daniel Muñoz and artist Juan Alba for Mundo Vid. A novel called El Pantera, or La Noche del Pantera was written by Muñoz in the 1990s, followed by El Misterio de la Amenaza Negra.

Gervasio Robles Villa, son of a white man and a Oaxacan Indian woman, is imprisoned for assassinating his fiancée, a crime that he did not commit. During the time he was in jail, he learned Wushu from a mysterious man called "El Indio" (a Native American convicted for tax evasion). The Main General of the police, Porfirio Ayala, convinced of Villa's innocence, decides to release him and return him the life he was taken from. Nevertheless, this act of kindness is conditional. Gervasio will be able to remain free under one condition: he must work secretly with the police and to catch criminals who inhabit the city. Now, El Pantera must find himself, recover his life and discover what his destiny is, to be known as “The Panther”. Once in the city he meets a beautiful woman named Lola. Despite the fact that Lola has a past that not every woman would be proud of El Pantera falls in love with her.

In the 2nd Season, El Pantera must confront a new truth, that his girlfriend Rosaura was not killed, but faked her death in order to ascend to the title of "Reina del Narco" loosely translated as "Queen of the Drugtrade", as daughter of "El Rubio Barrios" she was in charge of running the Gulf Drug Cartel. El Pantera then must fight against Police, the Mexican Army, the Pacific Cartel, Korean Mafias and the DEA to save the woman he still loves from torture, death, and even her own ambition.