Collaborators

Detail Information

Publications6

A F KolbInstitute of Virology and Immunology, University of Wurzburg, GermanyJ Gen Virol 78:2795-802. 1997

..These changes were sufficient to convert porcine APN into a functional receptor for HCV 229E and thus define a small number of residues that are critically important for the HCV 229E receptor function of human APN...

Molecular analysis of the coronavirus-receptor function of aminopeptidase N

A F KolbInstitute of Virology and Immunology, University of Wurzburg, GermanyAdv Exp Med Biol 440:61-7. 1998

..A further analysis of the mapped amino acid segments by site directed mutagenesis revealed that a short stretch of 8 amino acids in the hAPN protein plays a decisive role in mediating HCV 229E reception...

A HegyiInstitute of Virology and Immunology, University of Wurzburg, GermanyJ Gen Virol 79:1387-91. 1998

..This is surprising as neither human nor porcine APN by themselves mediate FIPV infection. These results suggest that different determinants in the APN protein are involved in mediating the coronavirus receptor function...

A F KolbInstitute of Virology and Immunology, University of Wurzburg, GermanyGene 203:209-16. 1997

..This methodology will be particularly useful for genomic targeting experiments in transgenic animals...

A functional eukaryotic promoter is contained within the first intron of the hGH-N coding region

A F KolbInstitute of Virology and Immunology, University of Wurzburg, GermanyBiochem Biophys Res Commun 247:332-7. 1998

..This internal hGH-N promoter can interfere with the transcriptional control elements of a promoter linked to the hGH-N coding region and thereby complicate the interpretation of data obtained with hGH-N as a reporter gene...