Description of Research Expertise

Research Interests
- Role of adapter proteins in immune cell development and function
- Signals leading to T cell activation and termination of T cell responses
- In vitro and in vivo function of mast cells and neutrophils

Description of Research
Our laboratory studies the regulation of signaling events that lead to hematopoietic cell development and function. We make extensive use of genetically altered mice for these studies. To date, we have identified three novel adapter proteins and have made mice deficient in each of these molecules. We have also investigated the role of enzymes by targeted gene deletion. Collectively these studies have provided new insights into how these proteins serve as regulators of multiple lineages in the hematopoietic system.