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WESTCHESTER COUNTY, N.Y. -- Some 150 local children with life-threatening medical conditions will get a helping hand from Major League Baseball Commissioner Rob Manfred when he's honored Friday at this year's annual Hudson Valley Make-A-Wish Ball.

The gala, which is the chapter’s biggest fundraiser each year, will get underway at 6 p.m., at the historic Abigail Kirsch at Tappan Hill Mansion, the former estate of Mark Twain, in Tarrytown.

Manfred, along with hundreds of other guests and community leaders from throughout the Hudson Valley, will pay tribute to the courage of the more than 2,500 children whose wishes have been granted since the chapter was established in 1986.

Thomas J. Conklin, president, and CEO of Make-A- Wish Hudson Valley said it was exciting to have Manfred as the honoree and to recognize him for his contributions to the organization.

“He and his family, who live in the Hudson Valley, have been long-time supporters of the chapter. For the past two years— and with a third year set for June 1— his participation in the JP Doyle’s Charity Softball Game has helped raise more than $40,000 for the cause,” Conklin added.

Manfred, elected as MLB’s 10th commissioner in 2014, set goals for the industry that focused on the expansion of youth participation, international growth, improved pace of the game, the infusion of technology, increased marketing of young stars and improving the game’s diversity goals.

Manfred is a graduate of Cornell University and Harvard Law School. He and his wife, Colleen, have four adult children.

The Wish Ball, which sells out early, will feature live and silent auctions, cocktails, dinner, and dancing. Guests will have the opportunity to adopt a child’s wish during the evening’s live auction.

Tickets are $425 per person or $4,000 for a table of 10. To purchase tickets call Megan Laurelli at 914-478-9474.