February 25, 2014

Ball State Professor Studies Effects of Hypoglycemia

The police pull over a driver, worried that he is drunk. He
seems confused and unable to concentrate.
However, he has no alcohol in his system. What’s going on?

It turns out that this driver has diabetes and has become
hypoglycemic. Bart Pederson, Associate Professor of Medical Education, explains
that this is something people with diabetes deal with on a regular basis –
especially those who have Type 1 diabetes, where they are taking insulin every
day. “There’s a good chance of them going hypoglycemic. They give themselves
too much insulin and their glucose drops too low. Some papers say this happens
as much as twice a week. It has major effects on their ability to think
clearly. It makes them tired, confused,” Pederson explains. “There’s definitely
a need to understand this disorder better and how to treat it.”

Understanding hypoglycemia is what Pederson is working to do.
While studying glycogen metabolism during his post-doctoral research, he
investigated genetically engineered mice whose bodies couldn’t make glycogen. Having
that resource available led Pederson to his current project, which involves
studying the importance of brain glycogen in memory formation and the protection
it may provide for the brain under hypoglycemic conditions. “Hypoglycemia is
the major obstacle preventing the benefits associated with intensive insulin
therapy in individuals with diabetes. Low glucose levels can lead to cognitive
impairment and even brain damage,” he says.

The National Institutes of Health (NIH) have seen the value in Pederson’s
work, awarding him grants in 2008 and 2013. His current project pursues two
aims. “The first aim is investigating the less severe cases, where people can’t
think well,” he explains. “We’re using these mice, we give them insulin, make them
hypoglycemic, and there’s different sorts of memory or learning tests we can do.”

How does one determine if a mouse is learning? One test,
which Pederson calls “log rolling for mice,” measures motor learning skills.
Mice are put on a rod that rotates and they try to stay on it. A normal mouse
gets a little better at this every day. But a hypoglycemic mouse does not
perform nearly as well. It has a harder time with coordination and learning to
adjust for the rotation.

The second aim of the grant involves looking at severe
conditions. “These are conditions that in humans can actually lead to coma.
Brain cells are dying off because there’s not enough fuel for them to survive –
they’re just deprived. And so in that case what we do is make our mice hypoglycemic
and then again we compare – does it make any difference whether you have
glycogen in your brain?” Pederson says. “Under these conditions where you
basically can’t measure any glucose in their brains, the only fuel left would
be glycogen. So you’d expect that if you don’t have any glycogen you don’t have
any fuel, so more brain cells would die. And that seems to be the case from
what we’ve seen so far.”

Working with students has become essential to Pederson’s
research. “When I first came, I did a fair amount of things in the lab,” he
says. “But now my role is mainly teaching the students the techniques and
helping them to troubleshoot problems that arise, teaching them the background
behind what we’re doing and the relevance.”

Immersive learning with students in research can lead to
some interesting results. “I joke with them that I’m always rewriting my
protocols because they come up with some way to do things wrong that I never
would have thought of before!” Pederson says. “It just shows that you can’t assume
things.”

Despite any hiccups the students may cause, they are
essential to Pederson’s research. “If I didn’t have any students, nothing would
get done! They’re the hands that do everything.”

Associate Professor Bart Pederson and his student researchers.

Pederson was inspired to study diabetes because of the sheer
number of people with the disease – 350 million worldwide. He was also inspired
by one specific person – his grandfather, who struggled with diabetes
throughout his life.

Pederson also just enjoys conducting research. “You’re
getting to explore something that’s new. People haven’t been able to answer
this question. You get to study it and hopefully find some answers. It’s exciting
to make a new discovery.”

1 comment:

You are doing a wonderful work with this research, Bart. With my personal experiences with Hypoglycemia and low blood sugar is there a way of preventing brain cell loss besides eating more smaller meals during the day to keep glucose levels in the blood at all times? I do experience times of memory failure when it comes to names of people that I've known for many years and also failure to remember conversations I just had with folks within minutes. This doesn't occur during the hypoglemic/glycogen times but just sporadically as memory fails me. Perhaps there's a correlation between glycogen increase and memory loss that's brain deteriorating over time. Anyway as you find bad ways of finding the solution you become that much closer to finding the cure! How many times did Edison fail before the light bulb turned on? If you have any helpful tips I'm all ears.