Antioxidants exhibit a defense system which plays a vital role in preventing oxidation of proteins, carbohydrates, lipids and DNA. They inhibit the oxidation processes that are responsible for the formation of free radicals leading to chain reactions. So antioxidant activity of different systems has been evaluated by different researchers. Ascorbic acid commonly known as Vitamin C is an oxidation- reduction catalyst which promotes the elimination of free radicals produced by the body itself and has the ability to remove pollutants that enters into our body. The most active component of turmeric is curcumin which has also proven its antioxidant properties. Curcumin is a polyphenol compound in which aromatic rings are connected with unsaturated carbonyl groups. Similarly ascorbic acid also contains hydroxyl groups. Acousical study find extensive applications in studying physico-chemical behavior and molecular interactions of different liquid systems. This paper aims at studying interaction behavior of solution mixture of these antioxidants in different solvent media through acoustical study. Ultrasonic velocity and related parameters are very important in designing new theoretical models. The density and ultrasonic velocity of solution mixture of ascorbic acid and curcumin in methanol, ethanol, 1-propanol and acetone solvent media are measured at room temperature over the varying composition. These solvents have been choosen in order to investigate solvent effect on the interaction of these antioxidants. These experimental data have been used to calculate the ultrasonic parameters such as isentropic compressibility ( ), inter molecular free length ( ), acoustic impedance ( ), apparent molar compressibility ( ), apparent molar volume ( ), excess parameters like excess volume ( ),excess intermolecular free length ( ), acoustic impedance ( ), excess isentropic compressibility ( ) and the results are discussed in terms of molecular interactions like hydrogen bonding and dipole-dipole interaction.