Evaluation of Pharmaceutical Equivalence of Different Brands of Diazepam Tablet in Bangladesh

Abstract:

The quality of pharmaceutical finished dosage forms is of major concern to the
pharmaceutical industries. An important aspect of the development of any pharmaceutical product is to maintain the quality standards of the product. Pharmaceutical preparations take many shapes and forms and are administered through variety of routes. Oral solid dosage forms particularly the tablet dosage form is the most well known of all. Tablet dosage form of any pharmaceutical company goes through many research studies and experiments to maintain the proper quality standards. Different quality control tests are done to ensure quality product. The aim of this study was to investigate the quality of different brands of diazepam tablets which are manufactured in Bangladesh. Diazepam is a drug affects on the central nervous system. So the quality of diazepam tablet such that it gives better pharmacological action, should not produce toxicity and the general appearance of a tablet, its visual identity and overall elegance is essential for consumer acceptance. Different physical parameters like hardness, thickness, friability as well as disintegration time were conducted to evaluate the quality of the tablets of different brands of diazepam. The range of hardness test result was 3.3-6.9 kg.. The friability test result were 0.198% and 0.177%. The thickness and weight variation results are in range of stander value. The disintegration test has a range value of 1.32-3.33 min. The hardness test of Easium brands was more than the usual standards. The excess hardness can delay the tablet breakdown process in the biological system. The friability test results are all in range. A good quality product must be able to withstand the undesired pressure. To determine this, friability test is necessary. The thickness test and weight variation test of two brands was complied with the standard values. Quality of a product is the major issue for any pharmaceutical company. To ensure quality product a pharmaceutical
industry follows the international standards. So it can be said that quality is the main
theme of any product. So to maintain the proper quality, quality control parameters must
be followed.

Description:

This thesis submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy (B.Pharm) of East West University, Dhaka, Bangladesh