Very high interrupt rates that correspond with high packet rate / network traffic.

The first is a fundamental bandwidth rate that you can't get around. The second could be a sign that you would benefit from jumbo frames or TCP offloading / that your system is being overloaded by interrupts due to the network traffic (making it difficult for the system to respond to other events.

the problem here is there are a bunch of tools listed and not way to get an integrated look. a tool like collectl monitors everything and lets you see cpu,disk,network,memory and even interrupts side by side either in real-time or written to a file for later playback.

if you suspect a cpu problem, look at individual cpu data and see how much time is spent in interrupt processing. if you do suspect interrupt overhead collectl will even show you interrupts by cpu and even allow you to break it out by specific interrupt type by cpu. truly a swiss-army knife knife kind of a tool that can easily replace many others.