Human MMP-9 Platinum ELISA 10 x 96 tests

Human MMP-9 Platinum ELISA 10 x 96 tests

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Human MMP-9 Platinum ELISA 10 x 96 tests

Product Code: BMS2016/2TEN

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The human MMP-9 ELISA is an enzyme-linked immunosorbent assay for the quantitative detection of human MMP-9. The human MMP-9 ELISA is for in vitro diagnostic use. Not for use in therapeutic procedures.

MMP-9 is a Zn+2 dependent endopeptidase, synthesized and secreted in monomeric form as zymogen. The structure is almost similar to MMP2, another member of matrixmetalloproteinase family.

Like other proteolytic enzymes, MMP-9 is first synthesized as inactive proenzyme or zymogens. Activation of proMMP-9 is mediated by plasminogen activator/plasmin (PA/plasmin) system. The regulation of MMP-9 activity is also controlled through TIMP-3.

MMP-9 plays an important role in tumor invasion, angiogenesis and metastasis. Increased levels of MMP-9 have been demonstrated in colorectal cancer, in acute leukemia, breast cancer, human melanoma and bladder cancer. MMP-9 potentiates pulmonary metastasis formation and glioma invasion. Apart from its function in tumor formation and spread, MMP-9 with its destructive effects is in close association with lung diseases and asthma. Leukocyte recruitment to the central nervous system MMP-9 means an involvement in the pathogenesis of multiple sclerosis. MMP-9 has a crucial role in reproductive endocrinology and shows a changed expression pattern after myocardial infarction.