Clobex (clobetasol propionate) Lotion is a topical (for the skin) steroid used to treat the inflammation and itching caused by a number of skin conditions such as allergic reactions, eczema, and psoriasis. Clobex Lotion is available in generic form. Common side effects of Clobex Lotion include:

The recommended dose is to apply Clobex Lotion 0.05% to the affected skin areas twice daily and rub in gently and completely. It is not likely other drugs you take orally or inject will have an effect on topically applied Clobex. But many drugs can interact with each other. Tell your doctor all medications and supplements you use. During pregnancy, Clobex should be used only if prescribed. It may be harmful to a fetus. It is unknown if this medication passes into breast milk or if it could harm a nursing baby. Consult your doctor before breastfeeding.

Our Clobex (clobetasol propionate) Lotion Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

The pooled incidence of local adverse reactions in trials
for psoriasis and atopic dermatitis with CLOBEX® (clobetasol propionate)
Lotion, 0.05% at 1.0% or greater was:

Adverse Reaction

Incidence

Skin Atrophy

4.20%

Telangiectasia

3.20%

Discomfort Skin

1.30%

Skin Dry

1.00%

Other local adverse events
occurred at rates less than 1.0%. Similar rates of local adverse reactions were
reported in the comparator (clobetasol propionate cream, 0.05%). Most local
adverse events were rated as mild to moderate and they are not affected by age,
race or gender.

The following additional local adverse
reactions have been reported with topical corticosteroids. They may occur more
frequently with the use of occlusive dressings and higher potency
corticosteroids, including clobetasol propionate. These reactions are listed in
an approximate decreasing order of occurrence: irritation, dryness,
folliculitis, acneiform eruptions, hypopigmentation, perioral dermatitis,
allergic contact dermatitis, secondary infection, striae and miliaria.