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Unfortantly since the manga is 18 volumes 162 Chapters and they are doing roughly 2 chapters per episode (actually very close to exactly 2c/ep so far). I guess roughly 20 chapters will be cut. Probably the side story of some characters, probably how Lunge lost his position in the BKA by forcing that secretary to confess and ultimately make him suicide.

that's one of the things make Naoki Urasawa so special. He is a master in telling stories across a long period of time and switching to different locations on the way. 20th Century Boys further develops this "space-time switching/jumping" story-telling technique that stories are told back and forth in time and locations are switched across the whole world. Now 20th Century boys already spans 2.5 generations from the 1970's to 2018.

Unfortantly since the manga is 18 volumes 162 Chapters and they are doing roughly 2 chapters per episode (actually very close to exactly 2c/ep so far). I guess roughly 20 chapters will be cut. Probably the side story of some characters, probably how Lunge lost his position in the BKA by forcing that secretary to confess and ultimately make him suicide.

Spoiler:

Although how Lunge was isolated within BKA is rather important to the whole story. He had bigger fish to fry when this happened. So he is left with nothing other than the middle age couple serial murder case, and Dr. Tenma. And he pursuit Dr. Tenma with the singular determination.

Most likely, some of the stories about the people Tenma helped and saved will have to be parred. When he was finally arrested, we got a snippet of people he helped and saved while on the run, and the police was surprised by the number of people who continued to stand by his claim of innocience.

Well, if its 20 chapters to much, i really believe the makers of anime will just pick 20 episodes at good points (where there isnt too much happening) and make 3 chapter episodes.
Nobody forces them to do 2 chapters every week the next 1.5 years....