Season three began airing September 24, 2006 and featured a total of 23 episodes and one clip show. It has been six months since Orson Hodge ran Mike over with his car. Bree, who has finally put Rex's death behind her, marries Orson. At their engagement party, a mysterious woman accused him of killing his wife, and as the season progress, his horrific past is revealed. Lynette, meanwhile, has to adjust to having another child around the house when Tom's ex is killed and they have to take her daughter in. The Scavos also leave their careers to open a pizzeria.

Gabrielle, divorces Carlos, after finding out he cheated on her with their former maid and surrogate mother, and finally founds a new love in politician Victor Lang. Edie sees her chance when Mike is shown to suffer from amnesia, and Susan moves on unto handsome englishman Ian Hainsworth. Finally, Edie's son Travers McLain pays a visit, as well as her nephew Austin, who starts a relationship with both Julie and Danielle.