Journal of Vestibular Research - Volume 6, issue 4

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ISSN 0957-4271 (P)

ISSN 1878-6464 (E)

Impact Factor 2018: 2.865

The Journal of Vestibular Research is a peer-reviewed journal that publishes experimental and observational studies, review papers, and theoretical papers based on current knowledge of the vestibular system, and letters to the Editor.

The subjects of the studies can include experimental animals, normal humans, and humans with vestibular or other related disorders.

Abstract: VOR parameters were compared in subjects at the extremes of the seasickness susceptibility scale. Thirty-nine subjects highly susceptible to seasickness and 30 nonsusceptible subjects participated in the study. The VOR was evaluated by the Sinusoidal Harmonic Acceleration (SHA) test at frequencies of 0.01, 0.02, 0.04, 0.08, and 0.16 Hz. In subjects susceptible to seasickness, VOR gain was significantly higher at 0.02 and 0.04 Hz, and phase lead was significantly lower at 0.01, 0.02, 0.04, and 0.08 Hz, than in nonsusceptible subjects. Our findings are in agreement with the notion that the vestibular response will be more intense in subjects susceptible…to motion sickness. The present results support the contention that a natural insusceptibility, or increased resistance to seasickness produced by adaptive responses to repeated sea exposures, may be reflected by lower VOR gain and higher phase lead.
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Abstract: The functional status of the velocity storage mechanism was studied in patients at long-term follow-up (2 to 4 years) after unilateral vestibular neurectomy. The time constant of the vestibulo-ocular reflex (VORtc), the effect of head tilt on postrotatory nystagmus, optokinetic after-nystagmus (OKAN), and nystagmus after rapid head shaking were studied in 10 patients. In agreement with previous findings, VORtc was found to be short and most patients manifested OKAN, suggesting that unilateral peripheral vestibular loss is associated with a complete loss of storage within the the VOR but only a partial loss of velocity storage for visual input. However, at…postrotatory head tilt the VOR time constant was further shortened, supposedly due to discharge of functioning velocity storage. Moreover, most patients manifested nystagmus after head shaking. These findings on tilt suppression and head-shaking nystagmus suggest that velocity storage within the VOR may function even in patients with complete unilateral vestibular lesions.
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Abstract: We compared in albino and pigmented rats the early effect of unilateral labyrinthectomy (UL) on the concentrations of monoamines (norepinephrine, dopamine, serotonin) and their respective metabolites—3-methoxy, 4-hydroxyphenylglycol (MHPG), 3,4-dihydroxy-phenylacetic acid (DOPAC), and 5-hydroxyindoleacetic acid (5HIAA)—in medial vestibular nuclei (MVN), locus coeruleus, raphe dorsalis, and cochlear nuclei. The study was conducted 6 hours after UL in both strains, differing by the functional optokinetic responses of their central vestibular neurons and the time-course of their vestibular compensation. The results show that the monoaminergic changes are different in the two rat strains. In the MVN of albino rats, there was a bilateral increase…of MHPG and an ipsilateral increase of dopamine suggesting activation of norepinephrine synthesis and metabolism, whereas no such changes were observed in the MVN of pigmented rats. On the other hand, the simultaneous increase of norepinephrine and DOPAC observed in the contralateral locus coeruleus of albino rats suggested enhanced norepinephrine synthesis, whereas in pigmented rats the decreased norepinephrine content found in the ipsilateral locus coeruleus might reflect an earlier strong stimulation of NE release. These biochemical results confirm the relevant role of locus coeruleus noradrenergic innervation in vestibular compensation and also point out the involvement of norepinephrine of the MVN in the early stages of this process. The different strain-related noradrenergic responses observed on the 6th hour suggest that the involvement of central norepinephrine, particularly from locus coeruleus innervation, may be more crucial and more sustained in the albino than in pigmented rats. No serotonin and SHIAA changes were found in either brainstem nuclei of albino rats. In contrast, the increase of the ratio 5HIAA/5HT observed in raphe dorsalis, in ipsilateral locus coeruleus, and in both sides of MVN of pigmented rats suggested that UL induced an extended and enhanced utilization of 5HT in this strain.
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Abstract: The Tullio phenomenon consists of vestibular symptoms on exposure to high-intensity acoustic stimuli, reflecting pathological stimulation of semicircular canals or otoliths. We report a patient with posttraumatic Tullio phenomenon to illustrate how precise measurement of eye movements during auditory stimulation, using the magnetic search coil technique, may characterize movements that are not clinically apparent or easily measured by other means. Such measurements in patients with surgically verified lesions may further elucidate the mechanisms responsible for this phenomenon.

Abstract: A technique has been developed for the comparison of predictive and nonpredictive ocular pursuit in human subjects, with the objective of estimating the contribution made by predictive processes to the normal pursuit response. Subjects were presented with a target moving at constant velocity in the horizontal plane and instructed to actively pursue the target or to passively stare at it. In the predictive mode (PRD), a step-ramp stimulus with velocity ranging from 12.5 to 50°/s was presented at regular intervals of 1.728 s, in alternating directions, with target exposure durations (PD) that varied from 80 to 640 ms. In the…interval between presentations, subjects were in complete darkness. In the nonpredictive mode (RND), similar step–ramp stimuli were presented but with randomized direction and timing of target exposure. In the nonpredictive mode, during both active and passive stimulation, the smooth component of eye velocity was initiated after a mean delay of 125 ms. In the predictive mode, eye velocity started to build up well before target onset, even during passive stimulation. It was found that the time of initiation of this anticipatory response was closely associated with the time at which the target would have changed direction even though the target could not be seen at this time. Eye velocity measured 100 ms after target onset was negligible in the nonpredictive mode, whereas in the predictive mode, it progressively increased with target velocity, reaching a maximum of 18°/s when target velocity was 50°/s and PD was greater than 240 ms. Examination of the difference in the eye velocity trajectories for the predictive and nonpredictive modes indicated that the greatest contribution of prediction occurred approximately 150 ms after target onset and its effects were evident in the predictive response for at least 300 ms. This effect was reflected in the reaction time between target onset and the occurrence of peak eye velocity. In the nonpredictive mode, this progressively increased from 250 ms to 400 ms as PD increased from 80 to 640 ms, whereas in the predictive mode peak velocity occurred an average of 50 ms earlier for all values of PD. The results demonstrate the significant contribution that predictive processes make to normal ocular pursuit behavior and the importance of timing control in this process. They also indicate that this process is not dependent on volitional control, but can be seen as an automatized response during passive stimulation.
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Abstract: The ability of the vestibulo-ocular reflex (VOR) to alter the phase of the motor output relative to the sensory input is examined. Alert cats were trained for 2 h with 0.25 Hz sinusoidal horizontal vestibular and vertical optokinetic rotational stimuli. In each experiment the optokinetic training stimulus was phase shifted by 0°, +45°, −45°, or 90° from the vestibular stimulus. Vertical and horizontal eye movements were measured during horizontal rotations in darkness before and after the training procedure. Phase-advance experiments (+45°) produced an adaptive vertical VOR with a mean phase of +28°. After phase-delay experiments (−45°), the adapted VOR had…a mean phase of −19°. The peak adaptive change in VOR gain was at or near the 0.25 Hz training frequency in each experimental group, but the gain depended in a complex manner on the testing frequency and the degree of phase shift of the training stimulus. Training with a 45° phase-delayed optokinetic stimulus produced an adaptive vertical VOR with a gain that was relatively higher at frequencies below the training stimulus than at those that were above. Training with a 45° phase-advanced optokinetic stimulus produced an adaptive vertical VOR with a gain that was higher at frequencies above the training frequency than at those that were below. During training with a phase-shifted optokinetic stimulus, adjustment of the relative efficacies of two neural pathways, a velocity pathway and an integrating pathway, could account for gain dependence on testing frequency and phase shift. This was corroborated by a model of the VOR that incorporates parallel velocity and integrating pathways. Data from 45° phase advances were fit by increasing the gain of the velocity versus integrating pathway, whereas 45° phase delay data were fit by decreasing the gain of the direct versus integrating pathway. The models altered the time constants of either the common oculomotor integrator or the velocity storage mechanism.
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Abstract: In artificial laboratory situations where subjects undergo repetitive self-generated or externally imposed head rotations, visual-vestibular interaction during the wearing of telescopic spectacles can markedly augment gain of the vestibulo-ocular reflex (VOR). The present study was conducted to determine whether the wearing of these aids for the visually impaired is associated with similar visual-vestibular interaction during more natural activities. Angular eye and head movements of unrestrained normal volunteers were measured using magnetic search coils. In some subjects, head translations and rotations were also monitored by a flux gate magnetometer array. Measurements were performed of the VOR in darkness, and of the…visually enhanced VOR (VVOR) in lit conditions, during three natural activities: 1) standing quietly; 2) walking in place; 3) running in place. These data were compared with similar measurements during repetitive voluntary head oscillations at 0.8 Hz in pitch or yaw. During VVOR, subjects viewed a target placed 6 to 10 m away and remembered this target during VOR trials in darkness. To assess the effects of altering visual-vestibular interactions, VVOR testing during normal vision was augmented by wearing of binocular telescopic spectacles of 2X, 4X, and 6X powers. Dorsoventral and mediolateral head translations were consistently phase-locked with pitch and yaw head rotations, respectively, such that head translation at least partially compensated for rotational disturbances of gaze. Angular velocity of the head was greater during walking than during standing, and was greater still during running, with a greater increase in each case for pitch as compared with yaw. Eye movements were phase compensatory for head movements. VOR gain (eye velocity divided by head velocity) was near 1.0 in both pitch and yaw during standing and during actively generated head rotation. During walking and running there was a significant decrease in angular VOR gain in pitch to approximately 0.75 (P < 0.0005). During ambulatory activities, normal and magnified vision were associated with VVOR gain enhancement in pitch and yaw that was statistically significant, but substantially less than was telescope magnification and markedly lower than was the corresponding VVOR gain measured during active head rotation. Measurements of unmagnified VOR and VVOR during walking and running showed that gain was lower than the “ideal” value of 1.0. However, since translational head perturbations during these activities partially offset the visual effects of angular disturbances, lower gains may nevertheless be associated with retinal image stability at typical indoor target distances. In contrast with performance during repetitive, uniplanar motion, vision has very limited influence on VOR gain during natural activities.
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Abstract: The involvement of NMDA (N-methyl-D-aspartic acid) receptors in the initial stage of the vestibular compensation was evaluated by examining the effect of MK-801 on this compensation in guinea pigs. MK-801, injected 30 min before induction of unilateral labyrinthectomy by an arsanilate, significantly (P < 0.05) reduced the maximum frequency of the spontaneous nystagmus (SN) towards both the arsanilate-applied and the intact sides. In addition, injection of arsanilate into the opposite middle ear, 60 days subsequent to induction of the unilaterial labyrinthectomy, suppressed the SN towards the second injected side, but had no effect on the SN towards the first injected…side. These results suggest that NMDA receptors may be linked to the initiation of the vestibular compensation.
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