STRING allows inspection of the interaction evidence for any given network. Choose any of the viewers above (disabled if not applicable in your network).

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:query proteins and first shell of interactors

white nodes:second shell of interactors

Node Content

empty nodes:proteins of unknown 3D structure

filled nodes:some 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

lpxD

UDP-3-O-acylglucosamine N-acyltransferase ; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (357 aa)

Predicted Functional Partners:

lpxC

UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase ; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis (469 aa)

0.998

PBAL39_23797

Lipid A disaccharide synthase, glycosyltransferase family 19 protein ; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (368 aa)

0.981

PBAL39_11657

Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase ; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (261 aa)

0.958

lpxK

Lipid A 4’-kinase ; Transfers the gamma-phosphate of ATP to the 4’-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4’-bis-phosphate (lipid IVA) (335 aa)

a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1

node2

node1 accession

node2 accession

node1 annotation

node2 annotation

score

PBAL39_01667

PBAL39_01677

PBAL39_01667

PBAL39_01677

Sugar phosphate isomerase, KpsF/GutQ family protein

2-dehydro-3-deoxyphosphooctonate aldolase

0.992

PBAL39_01667

PBAL39_03669

PBAL39_01667

PBAL39_03669

Sugar phosphate isomerase, KpsF/GutQ family protein

3-deoxy-D-manno-octulosonic-acid transferase

0.920

PBAL39_01667

PBAL39_11657

PBAL39_01667

PBAL39_11657

Sugar phosphate isomerase, KpsF/GutQ family protein

Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase ; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

0.906

PBAL39_01667

PBAL39_23797

PBAL39_01667

PBAL39_23797

Sugar phosphate isomerase, KpsF/GutQ family protein

Lipid A disaccharide synthase, glycosyltransferase family 19 protein ; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

0.917

PBAL39_01667

lpxC

PBAL39_01667

PBAL39_11652

Sugar phosphate isomerase, KpsF/GutQ family protein

UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase ; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis

0.773

PBAL39_01667

lpxD

PBAL39_01667

PBAL39_11647

Sugar phosphate isomerase, KpsF/GutQ family protein

UDP-3-O-acylglucosamine N-acyltransferase ; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

0.899

PBAL39_01667

lpxK

PBAL39_01667

PBAL39_08235

Sugar phosphate isomerase, KpsF/GutQ family protein

Lipid A 4’-kinase ; Transfers the gamma-phosphate of ATP to the 4’-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4’-bis-phosphate (lipid IVA)

0.897

PBAL39_01677

PBAL39_01667

PBAL39_01677

PBAL39_01667

2-dehydro-3-deoxyphosphooctonate aldolase

Sugar phosphate isomerase, KpsF/GutQ family protein

0.992

PBAL39_01677

PBAL39_03669

PBAL39_01677

PBAL39_03669

2-dehydro-3-deoxyphosphooctonate aldolase

3-deoxy-D-manno-octulosonic-acid transferase

0.881

PBAL39_01677

PBAL39_11657

PBAL39_01677

PBAL39_11657

2-dehydro-3-deoxyphosphooctonate aldolase

Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase ; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

0.873

PBAL39_01677

PBAL39_23797

PBAL39_01677

PBAL39_23797

2-dehydro-3-deoxyphosphooctonate aldolase

Lipid A disaccharide synthase, glycosyltransferase family 19 protein ; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

0.874

PBAL39_01677

lpxC

PBAL39_01677

PBAL39_11652

2-dehydro-3-deoxyphosphooctonate aldolase

UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase ; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis

0.736

PBAL39_01677

lpxD

PBAL39_01677

PBAL39_11647

2-dehydro-3-deoxyphosphooctonate aldolase

UDP-3-O-acylglucosamine N-acyltransferase ; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

0.872

PBAL39_01677

lpxK

PBAL39_01677

PBAL39_08235

2-dehydro-3-deoxyphosphooctonate aldolase

Lipid A 4’-kinase ; Transfers the gamma-phosphate of ATP to the 4’-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4’-bis-phosphate (lipid IVA)

0.870

PBAL39_03669

PBAL39_01667

PBAL39_03669

PBAL39_01667

3-deoxy-D-manno-octulosonic-acid transferase

Sugar phosphate isomerase, KpsF/GutQ family protein

0.920

PBAL39_03669

PBAL39_01677

PBAL39_03669

PBAL39_01677

3-deoxy-D-manno-octulosonic-acid transferase

2-dehydro-3-deoxyphosphooctonate aldolase

0.881

PBAL39_03669

PBAL39_11657

PBAL39_03669

PBAL39_11657

3-deoxy-D-manno-octulosonic-acid transferase

Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase ; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

0.896

PBAL39_03669

PBAL39_23797

PBAL39_03669

PBAL39_23797

3-deoxy-D-manno-octulosonic-acid transferase

Lipid A disaccharide synthase, glycosyltransferase family 19 protein ; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

0.951

PBAL39_03669

PBAL39_24540

PBAL39_03669

PBAL39_24540

3-deoxy-D-manno-octulosonic-acid transferase

UDP-2,3-diacylglucosamine hydrolase

0.490

PBAL39_03669

lpxC

PBAL39_03669

PBAL39_11652

3-deoxy-D-manno-octulosonic-acid transferase

UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase ; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis

0.893

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Network Stats

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Functional enrichments in your networkNote: some enrichments may be expected here (why?)

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Statistical background

For the above enrichment analysis, the following statistical background is assumed: