A mission control center (MCC, sometimes called a flight control center or operations center) is a facility that manages space flights, usually from the point of launch until landing or the end of the mission. It is part of the ground segment of spacecraft operations. A staff of flight controllers and other support personnel monitor all aspects of the mission using telemetry, and send commands to the vehicle using ground stations. Personnel supporting the mission from an MCC can include representatives of the attitude control system, power, propulsion, thermal, attitude dynamics, orbital operations and other subsystem disciplines. The training for these missions usually falls under the responsibility of the flight controllers, typically including extensive rehearsals in the MCC.

The Mission Control Center of the Russian Federal Space Agency (Russian: Центр управления полётами), also known by its acronym ЦУП ("TsUP") is located in Korolyov, near the RKK Energia plant. It contains an active control room for the ISS. It also houses a memorial control room for the Mir where the last few orbits of Mir before it burned up in the atmosphere are shown on the display screens.

Beijing Aerospace Command and Control Center is a command center for the Chinese space program which includes the Shenzhou missions. The building is inside a complex nicknamed Aerospace City. The city is located in a suburb northwest of Beijing.

Lockheed MartinA2100 Space Operations Center (ASOC)[3] in Newtown, Pennsylvania, US. In charge of several military satellites.

Mercury Control Center was located on the Cape Canaveral Air Force Station and was used during Project Mercury. One of its still standing buildings now serves as a makeshift bunker for the media if a rocket explodes near the ground.