Custom antibody development

We offer world-leading antibody development platforms based on a proprietary RabMAb® rabbit monoclonal platform, a phage display platform (AxioMx), and a next-generation sequencing platform (NGS-RabMAb®)

Target

Function

May act as an adapter protein to couple membrane receptors to intracellular signaling pathways. May be involved in signaling of ITGB2/LFA-1 and other integrins. Enhances HGF-MET signaling by recruiting Sos and activating the Ras pathway. Involved in activation of androgen and glucocorticoid receptor in the presence of their cognate hormones. Stabilizes TP73 isoform Alpha, probably by inhibiting its ubiquitination, and increases its proapoptotic activity. Inhibits the kinase activity of DYRK1A and DYRK1B. Inhibits FMR1 binding to RNA.

Tissue specificity

Ubiquitously expressed, with highest levels in testes, placenta, heart, and muscle, and lowest levels in lung. Within the brain, expressed predominantly by neurons in the gray matter of cortex, the granular layer of cerebellum and the Purkinje cells.

Phosphorylated upon DNA damage, probably by ATM or ATR. Phosphorylated in response to stress. Can be phosphorylated by the cleaved p110 form of CDC2L1 (p110C).Ubiquitinated. Polyubiquitination targets the protein for rapid degradation via the ubiquitin system. Can be deubiquitinated by USP11.

Cellular localization

Nucleus. Cytoplasm. A phosphorylated form is associated with the plasma membrane.

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This antibody is a Fast-Track antibody. It has not been fully characterized in Western blot. As such, we cannot guarantee its use in Western blotting; however, you may be able to earn 1000 Abpoints for being the first s...

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The synthetic peptide used to raise ab5295, anti-RanBP9 was GSCAFATVEDYLH, corresponding to C terminal amino acids 717-729 of Human RanBP9. Unfortunately the epitope of the antiserum has not been mapped.
I hope this i...

Thank you very much for contacting us regarding ab5295. I am very sorry to hear that you are experiencing difficulty with this antibody.
As you may know, ab5295 is one of our Fast-track antibodies and it is not yet fully characterized. We cannot gua...

Thank you for your enquiry.
ab5295 is currently a fast-track antibody and has not been fully characterized. According to the datasheet there is a 76% identity between the immunogen and the corresponding rat homolog. I would therefore consider it hi...

Thank you for your enquiry. I'm afraid that I can't send our customer's blot to you, all of our customer information is confidential. As stated on the datasheet, ab5295 is a Fast-Track antibody; Fast-Track antibodies are immunogen affinity purified and...

Thank you for getting back to us and for sharing your results with us.
As you probably know, this is a Fast-track antibody and it has not been fully characterized.
We have read through your protocol and would like to make the following suggestio...