Type of immunity mediated by neutrophils, macrophages and natural killer cells and includes epithelial barriers of the skin, GIT and respiratory tract.

Type of immunity mediated by lymphocytes and their products, and is normally silent and responds to the presence of microbes by becoming active, expanding and generating potent mechanisms for neutralizing and eliminating microbes.

Indicate type of hypersensitivity reaction:Acute rheumatic fever

Type II(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.120

Indicate type of hypersensitivity reaction:Myasthenia gravis

Type II(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.120

Indicate type of hypersensitivity reaction:Insulin resistant DM

Type II (TOPNOTCH)Robbins Basic Pathology, 8th Ed p.120

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Indicate type of hypersensitivity reaction:Pernicious anemia

Type II(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.120

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A special form of graft rejection occuring in the setting where preformed antidonor antibodies are present in the circulation of the host before transplant. Occurs within minutes to a few hours after transplantation.

Hyperacute rejection(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.133

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Rejection which occurs within days to weeks of transplantation in a nonimmunosuppressed host. Caused by both cellular and humoral immune mechanisms.

Acute rejection(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.133

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Acute rejection most commonly seen within the first months after transplantation, typically accompanied by signs of renal failure. Extensive CD4+ and CD8+ T-cell infiltration with edema and mild interstitial hemorrhage.

Acute rejection caused by antidonor antibodies. May take the form of necrotizing vasculitis with endothelial cell necrosis, neutrophilic infiltration, deposition of antibody, complement, and fibrin, and thrombosis.

Rejection which present clinically months to years after transplantation with a progressive rise in serum creatinine levels. Dominated by arteriosclerosis, interstitial fibrosis and loss of renal parenchyma.

Chronic rejection(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.133

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A multisystem autoimmune disease which principally affects the skin, kidneys, serosal membranes, joints and heart. Associated with autoantibodies including ANAs.

Pannus(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.146

Cytokine which plays a central role in the pathogenesis of RA.

TNF(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.146

A clinicopathologic entity with a triad of dry eyes, dry mouth and arthritis.

Sjogren syndrome(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.148

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Characterized by progressive fibrosis involving the skin, GIT and other tissues. May be a result of activation of fibroblasts by cytokines produced by T cells.

Systemic sclerosis(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.149

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A vascular disorder characterized by reversible vasospasm of the arteries. Typically the hands turn white due to vasospasm, then blue due to cyanosis, then red due to reactive hyperemia.

Raynaud phenomenon(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.151

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One of the more common forms of primary immune deficiency characterized by absent or markedly decreased numbers of B-cells in the circulation, with depressed serum levels of all classes if immunoglobulin.

Most common of all the primary immune deficiencies characterized by recurrent sinopulmonary infections and diarrhea.

A constellation of genetically distinct syndromes with common feature of defects in both humoral and cell-mediated immune responses, making affected infants susceptible to severe recurrent infections by bacteria, viruses, fungi, protozoans, and opportunistic infections.