Notice that there's not much SRAM available in the Uno. It's easy to use it all up by having lots of strings in your program. For example, a declaration like:

char message[] = "I support the Cape Wind project.";

puts 33 bytes into SRAM (each character takes a byte, plus the '\0' terminator). This might not seem like a lot, but it doesn't take long to get to 2048, especially if you have a large amount of text to send to a display, or a large lookup table, for example.

If you run out of SRAM, your program may fail in unexpected ways; it will appear to upload successfully, but not run, or run strangely. To check if this is happening, you can try commenting out or shortening the strings or other data structures in your sketch (without changing the code). If it then runs successfully, you're probably running out of SRAM. There are a few things you can do to address this problem:

If your sketch talks to a program running on a (desktop/laptop) computer, you can try shifting data or calculations to the computer, reducing the load on the Arduino.

If you have lookup tables or other large arrays, use the smallest data type necessary to store the values you need; for example, an int takes up two bytes, while a byte uses only one (but can store a smaller range of values).

If you don't need to modify the strings or data while your sketch is running, you can store them in flash (program) memory instead of SRAM; to do this, use the PROGMEM keyword.