About MPS II

This short video provides an overview of Mucopolysaccharidosis II (MPS II), or Hunter syndrome.

Mucopolysaccharidosis II (MPS II), or Hunter syndrome, is a serious genetic disorder that primarily affects males. It interferes with the body’s ability to break down and recycle glycosaminoglycans or GAGs.

In MPS II, GAGs build up in cells throughout the body due to a deficiency or absence of the enzyme iduronate-2-sulfatase (I2S). This buildup interferes with the way certain cells and organs in the body function and leads to a number of serious symptoms, such as declined cardiac function, obstructive airway disease, joint distortion and enlarged organs, to name a few.

In many cases, central nervous system involvement leads to developmental delays and nervous system problems.

MPS II is always severe, progressive, and life-limiting. It is a rare disease and one of several related lysosomal storage disorders (LSDs).

There are approximately 2000 cases of MPS II worldwide

The iBellieve Foundation is a registered Canadian charity and United States of America 501c3 non-profit organization, established by Simon Ibell to find a cure for MPS II (Hunter syndrome) and 50 related lysosomal storage disorders.