What researchers say about Glutathione as Peripheral neuropathy Treatment

Researchers report:

Several neuromodulatory agents such as calcium-magnesium infusions; antiepileptic drugs like carbamazepine, gabapentin, and venlafaxine; amifostine; a-lipoic acid; and [Glutathione] have demonstrated some activity in the prophylaxis and treatment of oxaliplatin-induced acute [Peripheral neuropathy].1

We retrospectively studied 51 Japanese adults with colorectal cancer who had received oxaliplatin-based chemotherapy to explore the pharmacogenetic association between oxaliplatin-induced [Peripheral neuropathy] and polymorphisms of the excision repair cross-complementation Group 1 (ERCC1) and [Glutathione]-S-transferases pi 1 (GSTP1) genes.2

Our data suggest that the combination of age and cutaneous messenger RNA levels of [Glutathione] S-transferase theta 2 and cathepsin A composes a strong indicator of disease severity in patients with Charcot-Marie-Tooth 1A, as quantified by the Charcot-Marie-Tooth [Peripheral neuropathy] Score.3

We evaluated the gene expression of [Glutathione] peroxidase, catalase, and superoxide dismutase (cuprozinc and manganese separately) in L4,5 dorsal root ganglion (DRG) and superior cervical ganglion, as well as enzyme activity of [Glutathione] peroxidase in DRG and sciatic nerve in experimental diabetic [Peripheral neuropathy] of 3 months and 12 months durations....Gene expression of [Glutathione] peroxidase, catalase, cuprozinc superoxide dismutase, and manganese superoxide dismutase were not reduced in experimental diabetic [Peripheral neuropathy] at either 3 or 12 months.4

About Glutathione

Glutathione (GSH) is an important antioxidant in plants, animals, fungi, and some bacteria and archaea, preventing damage to important cellular components caused by reactive oxygen species such as free radicals and peroxides. It is a tripeptide with a gamma peptide linkage between the carboxyl group of the glutamate side-chain and the amine group of cysteine (which is attached by normal peptide linkage to a glycine).1

About Peripheral neuropathy

Peripheral neuropathy (PN) is damage to or disease affecting nerves, which may impair sensation, movement, gland or organ function, or other aspects of health, depending on the type of nerve affected. Common causes include systemic diseases (such as diabetes or leprosy), vitamin deficiency, medication (e.g., chemotherapy), traumatic injury, radiation therapy, excessive alcohol consumption, immune system disease or viral infection. It can also be genetic (present from birth) or idiopathic (no known cause). In conventional medical usage, the word neuropathy (neuro-, "nervous system" and -pathy, "disease of") without modifier usually means peripheral neuropathy.2