I am having the same issue on two different UR44s in Cantabile, Cubase, and Kontakt Player, Keyscape, & UVI Workstation standalones. The audio remains digitized until I reset the driver / pause/restart the audio system in my hosts. I am on Win10 x64 with the latest 1.10 UR driver.

I actually thought I had the latest driver, since I updated via Steinberg updater.
It shows that steinberg provided 1.9.6. as their latest version.
Further digging in other posts I found a link to a yamaha usb driver version 1.10 (on a yamaha website)
Installing this version 1.10 has fixed the problem. I've been recording today without the usual dropouts and distorted sound.
It's just a little bit wierd that the steinberg updater gave me 1.9.6...

USB Frame Continuous Sync (default off)
We witnessed 500ms~800ms time stamp jumps in the USB streaming from PCs during our tests, and we concluded that some (or many?) PCs don't generate a proper USB time stamp that our previous drivers refer to, for the synchronization between input and output. From the version 1.10.1 for Windows, our driver check the time stamp information only at beginning, and it will free-run after that. In result, the problem should disappear.

Skip Initial Samples (default off):
Audio driver might send a chunk of non-audio signal just before starting to transmit audio data. The signal disturbs synchronization between Input and Output.
The option prevents such a case by ignoring the unnecessary signal.

Overload Detection (default on):
Audio driver informs DAW about a condition when CPU load gets close to overflow, then a DAW notices the user with a peak lump. Previous driver showed excessive reactions in several cases.

I'll be in the middle of recording, or even just watching netflix or something and the audio will become garbled and distorted. I need to hard reset the UR 22 with the power button to fix it. Sometimes it will go 2 minutes before exploding again and sometimes it will go an hour. Totally random. Have tried changing to a different USB port and that did not fix the issue.

I never had issues like this until recently (perhaps 1-2 months ago?) so perhaps its a windows update issue?

@Ed Doll
I have gone trough all the steps you recommended me after I filed a request to the support-team.
It does not work.
It is not a Cubase issue, it is clearly an issue between the UR22MKII and windows 10. I have seen other topics on this, with exact same issue, and no solution too.
What to do but You making an update to the Yamaha 10.4 driver to help these issues?
Regards, Inuk

This is crazy. After updating the drivers for those 2019 I can't work normally. It cracks every 15 minutes and make distorted sound until I restarted. Does anyone fix the issue here? Steinberg doesn't care at all about this?

My audio doesn't fade out when I listen to sounds on the internet, desktop , etc. But if i use my DAW the audio level fades out to very quite for 1 second and then goes back up again , and it repeats very often. Please do something about it.
In case there is no fix for it , how can I return my device by warranty ?

After lots of dropouts with Win10, I've had no dropouts or distortion (in a few hours of testing) when running UR22 mk II output from a Linux system (Ubuntu or Mint). You might consider ditching Win10 and using Ardour (if you need a DAW) under Linux Mint.