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In the beginning of this game a group of villains including Two-Face, Riddler, Mr. Freeze, Poison Ivy, and Clayface were attempting to perform thievery. After Batman manages to defeat Clayface, he discovers that Riddler escaped on Two Face's van. Batman attaches a tracker on the van and tracks them down. Batman follows the Riddler into Mr. Freeze's base and quickly defeats Mr.Freeze and continues to fight Poision Ivy who rescues Riddler. Batman defeats Poision Ivy and then defeats Two Face in an extended battle. The last battle is with Riddler, and Batman at last manages to defeat him as well. All the villains end up back in prison and Two-Face's plots were completely foiled by the Dynamic Duo.

In the beginning of LEGO Batman 2: DC Super Heroes, Two-Face is one of the numerous villains who raids The Man of the Year award ceremony, the others being Joker, Riddler, Penguin, and Harley Quinn. He is seen listening to Joker's acceptance speech intently on Lex Luthor's table after Joker steals the trophy from Bruce Wayne. When Batman and Robin arrive in the Bat-boat, he flees through the stage trapdoor with Joker, Riddler, and Penguin, only Harley stayed back to cover their flight. She was found and defeated by Batman and Robin.

Two-Face is later freed by Joker and Lex Luthor. Two-Face tried to escape the Asylum on his truck with Harley Quinn and Riddler but Batman and Robin arrived to prevent the breakout. He escaped shortly after with even more prisoners.