Having been raised in Spanish Harlem, Johnny grew up listening to Salsa music. His biggest influence in music was his Dad, who had a six-piece band for over 25 years. The band played merengue, trio, salsa, and Christmas music.

Johnny Mambo started playing congas with his dad at the age of 8 years old. At the age of 21, he met yet another influential figure, Mr. Eddie Iglesias (his music angel). Eddie was a well-known musician in the salsa genre circle. Eddie inspired Johnny to live his dream of forming his own band.

In 2005, Johnny Mambo formed his band, now known as Johnny Mambo & Friends. Johnny Mambo & Friends are currently a house band Red Rooster Harlem (every Tuesday for the past 5 years).

Johnny Mambo & Friends is a band that performs for the audience: the dancers, the salsa lovers, & the jammers. They consistently project a high energy performance on stage which transcends into the crowd. Their love for the art and passion for the beat allow them to connect with their audience and create a setting unlimited fun and fusion.