Calendula is applied to the skin to reduce pain and swelling (inflammation) and to treat poorly healing wounds and leg ulcers. It is also applied to the skin (used topically) for nosebleeds, varicose veins, hemorrhoids, inflammation of the rectum (proctitis), and inflammation of the lining of the eyelid (conjunctivitis).

Hypericum (St John's Wort) has also been used to be used topically to treat bruises, burns, insect bites and scabies.