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While on a stakeout with Metro P.D., Torres's partner mysteriously vanishes with the subsequent investigation leading NCIS to uncover new evidence from a decade-old murder while Ducky's friend, Cadence Darwin presents him with a new opportunity during his guest lecture series.

Continuing with the revelation that he was to act as a guest lecturer at a medical school in the events of Twofer (episode), Ducky is presented with, and ultimately accepts, a proposition to teach for a semester in New York.