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A basic question in cell biology is how a protein reaches its correct location within the cell. Of all the organelles in a mammalian cell, the mitochondrion is the most complex because two membranes must be crossed. In addition to the metabolic role, the mitochondria is a key player in many cellular processes including apoptosis, metal ion homeostasis and aging. Dr. Carla Koehler's research focuses on mitochondrial biogenesis, particularly the mechanism by which proteins are imported into the mitochondrial inner membrane and the process by which defects in mitochondrial protein translocation lead to disease.