erythroid

produced in in vitro cultures of erythroid stem cells. It has low sensitivity to erythropoietin and gives rise to colony forming unit-erythroid which, with erythropoietin, gives rise to erythroid cells.

In one of the largest studies to date, Voulgarelis et al (10) looked at 40 cases of SLE and similarly found frequent dysplastic changes, most notable in the erythroid and megakaryocytic lineages, as well as ALIP that showed striking similarity to the control cases of MDS, refractory anemia subtype.

In infection, cytokines and their products therefore cause: (i) a diversion of iron into iron stores in the RES, resulting in decreased iron concentration in the plasma, thus limiting its availability to red cells for haemoglobin synthesis; (ii) an inhibition of erythroid progenitor cell proliferation; and (iii) inappropriate production and activity of Epo.

In a presentation titled, "From GWAS to the Clinic: Genome-Editing the Human Bcl11a Erythroid Enhancer for Fetal Globin Elevation in the Hemoglobinopathies" (Abstract #53), new data were described demonstrating the effectiveness of knocking out the BCL11A Enhancer in hematopoietic stem and progenitor cells (HPSCs) as an approach to elevate fetal globin in a manner that is specific for red blood cell precursors (erythroid-specific), thereby eliminating any effect of reduced BCL11A expression in HSPCs or other non-erythroid lineages.

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