The authors found that heterochromatin protein 1γ (HP1γ) was upregulated in prostate cancer (PCa) and elevated levels of HP1γ in PCa predicted poor outcome. Depletion of HP1γ in PCa cells not only repressed proliferation and induced apoptosis but also impaired tumorigenicity. [Oncogene]
Abstract

Scientists performed sequential deletion and luciferase analysis of the l-plastin promoter and found that an androgen-independent regulatory factor prominently located in the region close to the transcription initiation site may facilitate l-plastin upregulation. [Cell Death Dis]
Full Article

Researchers analyzed the role of PUS10 in TRAIL-induced apoptosis by immunofluorescence, immunoblotting and several indicators of apoptosis. They examined several TRAIL-sensitive cell lines and resistant cell lines after treatment with cycloheximide. [Cell Death Dis]
Full Article

The authors investigated the protective effect of an aqueous extract of Cynanchum wilfordii against benign prostatic hyperplasia (BPH) development in a testosterone-induced BPH rat model. [Nutrients]
Abstract

Scientists developed a rapid strategy to screen a serum-free medium for culturing anchorage-dependent PC-3 prostate cancer cells, which was going to be prepared in large scale to generate GM-CSF/TNFα-surface-modified whole cell prostate cancer vaccine. [PLoS One]
Full Article

The authors found that exposure of LNCaP cells to H2O2 inhibited their viability and migration, and induced apoptosis, at a greater extent compared with the culture under normal conditions. [DNA Cell Biol]
Abstract

Strata Oncology, Inc. announced a collaboration with the University of California San Francisco (UCSF) to launch StratifyProstate™ a unique initiative focused on expanding access to tumor sequencing nationwide for men with advanced prostate cancer and to dramatically accelerate enrollment into relevant targeted therapy trials. [University of California, San Francisco]
Press Release

When the Navajo Nation opens its first oncology centre next year in Tuba City, Arizona, clinicians there may be able to offer a service that has been banned on tribal lands for 15 years: analyzing the DNA of Navajo tribe members to guide treatments and study the genetic roots of disease. [Nature News]
Editorial

The American Chemical Society (ACS) brought a case against Sci-Hub, a pirate site providing access to scientific articles, for copyright and trademark infringement. Following a hearing at a court in Virginia, Magistrate Judge John Anderson filed a report that recommended ruling in favor of ACS on all counts. [The Scientist]
Editorial

Anxiety is growing in Brazil over the country’s collapsing research budgets. President Michel Temer had slashed funding for science by 44% in March and has proposed additional decreases for 2018 — even as some science institutes run out of money for basic needs, such as paying electricity bills. The 2017 science budget, at 3.2 billion reais (US$1 billion), is the lowest the country has seen in at least 12 years. [Nature News]
Editorial