Critical Tissue Oxygen Thresholds for the Induction of Apoptosis in Critical Illness

Abstract

Cellular sensitivity and response to hypoxia play important roles in the pathogenesis of numerous disorders in critical care medicine. Defining the mechanisms by which mammalian cells and organisms adapt to acute and chronic perturbations in ambient oxygen tension is critical to the understanding of maintenance of homeostasis and consequently the development of therapeutic strategies to counteract hypoxia-induced cell damage.

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