1
mg/ml
(Please refer to the vial label for the specific concentration)

Purification

Purified by antigen-affinity chromatography.

Specifications: PAK4 antibody

Full Name

p21 protein (Cdc42/Rac)-activated kinase 4

Background

PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq]

Synonyms

p21 protein (Cdc42/Rac)-activated kinase 4 Antibody

Host

Rabbit

Clonality

Polyclonal

Isotype

IgG

Immunogen

Recombinant protein encompassing a sequence within the center region of human PAK4. The exact sequence is proprietary.