Schirripa was also the co-host on NBC's Today Show during its fourth hour with Kathie Lee Gifford, as Hoda Kotb was out. This occurred the week of July 17. He has appeared on the Tonight Show more than 40 times as a guest and as a correspondent. Schirripa hosted NBC's poker game show, Face the Ace, with the premiere episode airing on August 1, 2009.

In the fall of 2010, Schirripa had a guest star role in the digital comedy short film, "Lil DPC", from writer/director Michael Ratner, which also features Rapper Fat Joe and Blink 182'sMark Hoppus.

Schirripa is the host and narrator of the television true-crime series Nothing Personal,[8] which premiered in the U.S. on Investigation Discovery and in the UK on History. The series features true stories and reenactments of murders-for-hire. In addition to hosting the hour-long programs, Schirripa is one of the program's executive producers. The programs were filmed on location around the United States and in Ontario, Canada. As of April 2013, this season Schirripa is hosting another show on Investigation Discovery (IDSC) titled Karma's a B*tch! This show dramatizes individuals who were previously involved in a relationship with one another, and one of the individuals get hurt. The individual who was hurt decides to execute some type of karma.

Recently, Schirripa has provided the voice for the lemon in McDonald's McCafe Strawberry Lemonade commercials. He has also guest-starred in the American version of Top Gear.

Steve Schirripa played Sonny Rosselli in "A Poet Long Ago", a short film written by Pete Hamill and directed by Bob Giraldi, which gained entry into a number film festivals in 2013.

In 2014, Schirripa played Joey on the ABC series "Black Box", did voice acting in an episode of "American Dad!" entitled "Stan Goes on the Pill", and played Vito in the silver screen adaptation Jersey Boys, directed by Clint Eastwood. He will play Father Ed in "Chasing Yesterday", a film by Writer/Director Joseph Pernice, as well as be in the film "Houses", by Writer/Director Jenner Furst, alongside "Sopranos" co-stars Michael Imperioli and John Ventimiglia. Schirripa was also the executive producer and host of "Karma's a B*tch!", which aired its second season on Investigation Discovery.

In 2014, Steve Schirripa launched a line of organic, vegan pasta sauces under the business name of Uncle Steve's Italian Specialties Group. The company currently features three types of sauce: marinara, tomato basil, and arrabbiata. The sauces are available from Grace's Marketplace in Manhattan and Long Island, New York, on the company's website, and at Whole Foods.