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Release Notes
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The game begins in a hospital on the Sprawl, a densely populated metropolis
built on a shard of Titan, one of Saturn's moons.[12][13] Isaac Clarke has no
memory of the last three years, having just been released by Franco, the
protagonist of Dead Space Ignition. However, before he can remove the
straitjacket, Franco is killed and transformed into a necromorph, leaving Isaac
to escape on his own. He is later contacted by a woman named Daina, who guides
him to her location. He is also contacted by another patient, Nolan Stross,
claiming he and Isaac can destroy the Marker, which Hans Tiedmann, the station's
administrator, forced them both to rebuild after finding Isaac adrift. Ignoring
Stross, Isaac fights his way across the city, making his way to Daina. Upon his
arrival, two guards seize Isaac as Daina reveals that she is a Unitologist sent
to "recover" Isaac, claiming that he is responsible for building the Marker that
is causing the current infestation and that they need him to build more. As they
are about to leave, A Titan Security gunship guns down Daina and her associates,
allowing Isaac to escape.

Stross contacts Isaac again and he reluctantly decides to trust Stross, as his
only mission now is to destroy the Marker. Stross tells Isaac that the Marker is
located in the Government Sector under lockdown. As he makes his way there,
Isaac comes across another survivor, Ellie Langford, a CEC officer who
eventually joins their mission, deciding that she needs their help to survive.
As they progress through the Sprawl, Tiedemann throws several obstacles in their
way to stop them from getting to the Marker. Later, Stross' dementia worsens,
causing him to attack Ellie, stabbing her eye out with a screwdriver. She
survives, and later Isaac is forced to kill Stross in self-defense. As he fights
his way to the Marker Isaac experiences visions of Nicole, which become more
vivid as she tries to deter him from his task. Eventually he comes to accept the
guilt of Nicole's death, causing the Nicole visions to become friendly.

Upon reaching the Government sector, Isaac sends Ellie away alone on a gunship,
despite her protests. He does this because he reasons that, even though he could
not save Nicole, there is still time for him to save Ellie. Once inside, he
releases the doors holding back the necromorphs trying to get to the Marker, who
overwhelm Tiedemann's men. Isaac eventually comes upon the Marker, which is
surrounded by necromorphs. As Isaac looks on, the Marker begins "convergence",
an event foretold by the Unitologists. With the vision of Nicole guiding him, he
comes upon a machine that unlocks the blocked Marker-infected parts of his mind,
which Nicole claims will help him. He then fights his way to the Marker, where
he encounters Tiedemann, whom Isaac is forced to kill. Isaac then approaches the
Marker when the Nicole vision suddenly pulls Isaac into his own mind. There,
Isaac encounters the parts affected by the Marker and the Nicole vision, who
then reveals that the only way to make the Marker "whole" is to absorb the body
and mind of the one who created it. After a lengthy battle, Isaac is able to
destroy the Nicole vision and rid all traces of the Marker's influence from his
mind, destroying the Marker in the process.

Upon exiting his mind, Isaac slumps to the ground, ready to accept his fate as,
in a last act of desperation by Tiedmann's security forces, the station's power
core will detonate, destroying the station. Suddenly, Isaac receives a call from
Ellie, who crashes the gunship through the ceiling. As the room collapses, Isaac
makes his way onto the gunship and they escape.

After the credits, an audio transmission is heard between two people, an unknown
subordinate and his ranking superior (known only as "the Overseer" from one of
the text logs that can be collected during the course of the game). The
subordinate relays that Titan Station (which was Marker Site 12) and the Marker
have been destroyed. The Overseer replies that the other sites will then have to
ôpick up the piecesö.