SLC22A7 variants were not significantly associated with hyperuricemia and gout in a New Zealand Maori and Pacific cohort.

Two novel variants in SLC22A17 and SLC22A7 were significantly associated with anthracycline-induced cardiotoxicity.

suggest that OAT2-mediated cGMP uptake does not occur via exchange with monocarboxylates, dicarboxylates, and hydroxyl ions

the findings revealed the important role of OAT2 in renal secretion and possible reabsorption of creatinine and suggested a molecular basis for potential species difference in the transporter handling of creatinine

At physiologic creatinine concentrations, specific activity of OAT2 transport was over twofold higher than OCT2 or OCT3 (显示 POU5F1 ELISA试剂盒), establishing OAT2 as a likely creatinine transporter, challenging the view that creatinine is solely transported by a cationic pathway

Antigen Summary

The protein encoded by this gene is involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and appears to be localized to the basolateral membrane of the kidney. Alternatively spliced transcript variants encoding different isoforms have been described.