Weitere Antikörper gegen C-JUN Interaktionspartner

Human Jun Proto-Oncogene (JUN) Interaktionspartner

The positive feedback regulation of OCT4 (zeige POU5F1 Antikörper) and c-JUN, resulting in the continuous expression of oncogenes such as c-JUN, seems to play a critical role in the determination of the cell fate decision from induced pluripotent stem cells to cancer stem cells in liver cancer.

Integrative genomic analysis indicated overexpression of the AP-1 (zeige FOSB Antikörper) transcriptional complex suggesting experimental therapeutic rationales, including blockade of the renin (zeige REN Antikörper)-angiotensin system. This led to the repurposing of the angiotensin II receptor antagonist, irbesartan, as an anticancer therapy, resulting in the patient experiencing a dramatic and durable response.

Knockdown of CD44 (zeige CD44 Antikörper) reduced the protein level of xCT (zeige SLC7A11 Antikörper), a cystine transporter, and increased oxidative stress. However, an increase in GSH was also observed and was associated with enhanced chemoresistance in CD44 (zeige CD44 Antikörper)-knockdown cells. Increased GSH was mediated by the Nrf2 (zeige GABPA Antikörper)/AP-1 (zeige FOSB Antikörper)-induced upregulation of GCLC (zeige GCLC Antikörper), a subunit of the enzyme catalyzing GSH synthesis

This is the first study to show how TGF-beta (zeige TGFB1 Antikörper) regulates the expression of Claudin-4 (zeige CLDN4 Antikörper) through c-Jun signaling and how this pathway contributes to the migratory and tumorigenic phenotype of lung tumor cells.

Mouse (Murine) Jun Proto-Oncogene (JUN) Interaktionspartner

The positive feedback regulation of OCT4 (zeige POU5F1 Antikörper) and c-JUN, resulting in the continuous expression of oncogenes such as c-JUN, seems to play a critical role in the determination of the cell fate decision from induced pluripotent stem cells to cancer stem cells in liver cancer.

In transgenic mice with graded elevation of Schwann cell c-Jun, high c-Jun elevation is a potential pathogenic mechanism because it inhibits myelination. There was no link between c-Jun elevation and tumorigenesis. Modest c-Jun elevation, which is beneficial for regeneration, is well tolerated during Schwann cell development and in the adult and is compatible with restoration of myelination and function after injury.

C-JUN (JUN) Antigen-Profil

Beschreibung des Gens

This gene is the putative transforming gene of avian sarcoma virus 17. It encodes a protein which is highly similar to the viral protein, and which interacts directly with specific target DNA sequences to regulate gene expression. This gene is intronless and is mapped to 1p32-p31, a chromosomal region involved in both translocations and deletions in human malignancies.