Ipamorelin is a penta-peptide hormone
(Aib-His-D-2-Nal-D-Phe-Lys-NH2), a growth hormone secretagogue and
a small molecule ghrelin mimetic developed by Novo Nordisk.
Ipamorelin belongs to the most recent generation of GHRPs and
causes significant release of growth hormone. Similar to GHRP-6 and
GHRP-2, it suppresses somatostatin and increases the stimulation
and release of Growth Hormone (GH) from the anterior pituitary.
Currently, there are few clinical trials involving Ipamorelin,
which were first being studied in the 90s. Somatotropes are the
cells that are responsible for producing and releaseing GH.

These types of positive benefits have led some scientific studies
to determine that the peptide could carry several theoretical
benefits as they relate to the slowing down of the aging process.

How does it Work?

After an athlete administers Ipamorelin, a selective pulse is sent
that stimulates the hypothalamus/pituitary to release GH. This
pulse can endure for approximately three hours after injection.
Once the GH pulse is sent, the cells go directly to the muscle to
support development while staying clear of any possible bone or
cartilage growth. This is good for Ipamorelin users, as long term
usage will effect lean body muscle growth without the possibility
of experiencing any bone or cartilage deformities. The same cannot
be said for synthetic HGH users, who experience pronounced side
effect in swelling joints and even in some cases Carpel Tunnel.
Ipamorelin will increase cell synthesis, elevate secretion levels
of insulin from pancreatic tissue, and increase ghrelin in the
stomach – which helps release GH and control hunger. All of these
functions work to promote fat loss, shuttling of nutrients, and
building clean muscle mass.

Advantage Over GHRP-6, GHRP-2:

Ipamorelin increases number of somatropes and quantity of hgh
released from each somatrope; never induces hunger; only
selectively releases GH at any dose; does not release and increase
negative hormones like cortisol (stress / muscle loss) &
prolactin (water retention / sexual dysfunction / bitch tits); a
mega-dose of Ipamorelin will result in a mega-release of GH, where
as GHRP-2 & GHRP-6 have limits of 1mcg / kg

Side Effects:

This supplement is actually renowned for its lack of side effects
(or its very minimal side effects).Tests on subjects and reviews from real-life users do show some
possible side effects, such as headaches and feelings of being
light-headed. However, when compared to other
growth-hormone-releasing formulas, these side effects are typically
very mild (if they occur at all). This is one key reason why this
supplement is a popular choice with bodybuilders and with others
who wish to gain muscle mass and strength via supplements. It also
gets great press in the anti-aging industry.

Dose:

Ipamorelin, like other peptides, comes as a freeze dried powder
that is very delicate. You can store it in the refrigerator or at
room temperature before reconstituting. Once reconstituted with
bacteriostatic water, the vials must be stored in a cool dry place
like your refrigerator. Insulin syringes are the best way to
administer it, usually via subcutaneous injection.

Athletes are taking Ipamorelin in a 200mcg -300mcg dosage, two or
three times daily, using a tiny insulin needle to inject. They
usually start with the lower dose since side effects can include
headaches or what feels like a head-rush. Ipamorelin can be taken
at anytime but taking it about 30-45 minutes before a workout would
seem ideal because of the pulse in Growth Hormone (GH) it creates
allowing for maximum growth.

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