July 19 – Hall of Fame Negro League player Willard Brown makes his major league debut with the St. Louis Browns. Brown would only appear in 21 games for St. Louis in his only major league season, batting .179 with one home run and six runs batted in.

July 20 – With both Hank Thompson and Willard Brown in the starting line-up, the St. Louis Browns become the first major league club to field two black players at the same time. Both players play all nine innings of both games of a doubleheader with the Boston Red Sox.

August 20 – Washington Senatorsrelief pitcherTom Ferrick loses both games of a doubleheader with the Cleveland Indians. While pitching with the St. Louis Browns the previous season, Ferrick won both games of a doubleheader against the Philadelphia Athletics on August 4.

August 26 – Brooklyn Dodgers' Dan Bankhead became the first black pitcher in the majors. He homered in his first major league plate appearance, but didn't fare well on the mound. In 3 1⁄3 innings of relief, he gave up 10 hits and six earned runs to the Pittsburgh Pirates, who won the game, 16–3.

November 27 – Triple Crown winner Ted Williams (.343 BA, 32 home runs, 114 RBI) is edged out by Joe DiMaggio (.315, 20, 97) for the American League MVP Award by one point. One BBWAA member fails to include Williams anywhere on his ballot.