1. 1520: A Smallpox pandemic which took lives of 5-8 million people in 15th century

Smallpox was an unknown disease not only in Mexico, but in the Americas, before the arrival of Europeans. It was introduced to Mexican lands by the Spanish and played a significant role in the downfall of the Aztec Empire in Mexico. Hernan Cortes ane spanish ruler with his troops Mexico ki ravadam appude smallpox mexicans ki sokadam tho nearly 5-8 Million mexicans chanipoyaru at that time.

2. 1620: – The Great Bubonic Plague also known as Black Death and Black Plague

After the 1520 Pandemic, correct ga 100 years ki Plague mahammarri marosari in between 1620-1665, The Great Bubonic Plague took 25 Million lives in Europe Alone.

3. 1720: The Great Plague of Marseille resulted in 1 Lakh deaths and infected many in European countries

In 1720 there was a deadly pandemic of bubonic plague. It started in Marseille and was later called “The Great Plague of Marseille.” The researchers estimated the number of deaths as 100,000. Aa time lo kuda…ila labs, hospitals lantivi em lekunna The Sanitation Board established a three-tiered control and quarantine system.

4. 1820: The first cholera pandemic (1820–24), also known as the first Asiatic cholera pandemic or Asiatic cholera:

5. 1920: ‘The Spanish Flu’ infected 500 million people—about a quarter of the world’s population at the time.

Very after World War – 1, The Spanish Flu evolved in Spain regions and spread to the UK,US, China between January 1918 to December 1920. This flu resulted in a death toll estimated to have been anywhere from 17 million to 50 million, infecting 500 million people at that time.