Comparison of visual effects of immersion fluids for dermoscopic examination of acral volar melanocytic lesionsTzu-Hsiu Chen, Shu-Hui Wang, Lin-Hui Su, Yu-Ling Hsu, Tsung-Hua Tsai, Ya-Jing Hsu, Ying-Jui Chang
DERMATOLOGICA SINICA 32 (2014) 69-74
Background
Acral volar melanocytic lesions have a high potential for malignancy. Dermoscopy is a useful, noninvasive tool for the diagnosis of such malignancies. The use of immersion fluids can provide better visual effects and improve the diagnostic accuracy of dermoscopic examinations.
Methods
Fifteen volar melanocytic lesions, including two palmar and 13 plantar lesions, were included in our study. We compared the visual effects of two different immersion fluids as an interface for dermo ..................More

Lymphomatoid papulosis in association with mycosis fungoides: A clinical and histopathologic review of five Taiwanese casesChien-Hun Huang, Chao-Kai Hsu, Julia Yu-Yun Lee
DERMATOLOGICA SINICA 32 (2014) 75-81
Background/Objectives
Lymphomatoid papulosis (LyP) is a cutaneous CD30+ lymphoproliferative disorder characterized by recurrent, self-healing lesions with a chronic clinical course. Approximately 10–20% of the patients have lymphomas, including mycosis fungoides (MF). LyP in association with MF is not well documented in Taiwan. We aimed to describe the clinicopathologic characteristics of LyP with MF in a Taiwanese case series of LyP.
Methods
A retrospective clinicopathologic study was pe ..................More

Chronic actinic dermatitis: A clinical study of 15 cases in northern TaiwanTzu-Lin Hsiao, Chia-Yu Chu
DERMATOLOGICA SINICA 32 (2014) 82-86
Background
Chronic actinic dermatitis (CAD) is an idiopathic photosensitive dermatosis induced by ultraviolet B (UVB), sometimes ultraviolet A (UVA), and occasionally visible light. Diagnosis is suggested by the clinical findings, typically a chronic eczematous rash on the sun exposed areas, and confirmed by phototesting, which demonstrates the abnormal photosensitivity. The aim of this study was to determine the characteristics of CAD in Taiwanese patients.
Methods
We retrospectively revie ..................More

Case Report

A woman with juxta-articular nodules—An uncommon form of subcutaneous granuloma annulareLili Wang, Wenlin Yang
DERMATOLOGICA SINICA 32 (2014) 87-89
Granuloma annulare is a benign inflammatory dermatosis that is most common in children and young adults. The subcutaneous form of granuloma annulare, which occurs mainly on the extremities in children, is rare. Lesions usually occur as painless subcutaneous nodules without inflammation of the cutaneous surface; the most frequent sites are the legs, buttocks, and scalp. Nevertheless, we present a case of subcutaneous granuloma annulare confined to the dorsa of the hand joints and right knee in a ..................More

d-Penicillamine induced elastosis perforans serpiginosa with involvement of glans penisYao-Nien Chuang, Chun-An Yao, Tsu-Man Chiu, Kuo-Chia Yang, Yueh-Min Lin, Hsiu-Cheng Hsu
DERMATOLOGICA SINICA 32 (2014) 93-96
Elastosis perforans serpiginosa (EPS) is an unusual perforating disorder characterized by extrusion of altered elastic fibers through the epidermis. Clinically, it presents as keratotic papules with a tendency for serpiginous or annular distribution that most commonly involves the sides of the neck and the back. However, involvement of the penis has rarely been reported. We present a case of EPS involving the neck, axilla, and glans penis in a 42-year-old man who had received long-term d-penicil ..................More

Severe dermatomyositis with pronounced generalized subcutaneous edema and dysphagia: A rare manifestation of a highly active diseaseAmy Chia-Ying Peng, Chien-Hun Huang, Tsy-Sheng Lin, Julia Yu-Yun Lee
DERMATOLOGICA SINICA 32 (2014) 97-100
Abstract
Severe subcutaneous edema is rare in dermatomyositis (DM). Such patients usually have a highly active disease, which requires aggressive treatment. To date, there are 14 reported cases of generalized edema secondary to adult DM. We described a severe case of DM manifesting generalized edema, oropharyngeal dysphagia, and dysarthria. A 44-year-old female presented with a typical rash of DM, proximal muscle weakness, and marked swelling of the limbs and face. The findings in the skin biop ..................More

Bruise-like cutaneous lesions as the early presentation of blastic plasmacytoid dendritic cell neoplasmYi-Hsuan Chou, Ruey-Yi Lin, Meng-Sui Lee, Hsiao-Ping Wu, Che-Pin Lin, Chen-Yi Wu
DERMATOLOGICA SINICA 32 (2014) 101-106
Abstract
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a very rare and highly aggressive hematopoietic malignancy associated with a poor prognosis. It has been recognized to originate from precursors of plasmacytoid dendritic cells and has recently been established as a distinct entity. The most frequent clinical presentations are prominent skin lesions, followed by peripheral blood, bone marrow, and other organ involvement. Treatment outcomes are often disappointing due to a high rel ..................More

Unilateral seborrheic dermatitis following the excision of the trigeminal schwannomaYao-Yu Chang, Pei-Hsuan Lu, Chih-Hsun Yang
DERMATOLOGICA SINICA 32 (2014) 110–112
Seborrheic dermatitis (SD) is a common chronic recurrent dermatitis characterized by ill-defined erythematous patches with overlying fine scaling either with or without yellow crusts.1 A transient infantile form of SD often resolves within the first 3–4 months of life. The majority of SD appears to affect adult men more than women, and it is not uncommon for it to present after 50 years of age.1 SD is mainly distributed symmetrically in areas rich in sebaceous glands. Face, ears, scalp, and up ..................More

Coexisting staphylococcal scalded skin syndrome and acute generalized exanthematous pustulosisThomas Waitao Chu, Shu-Hui Wang, Ching-Chi Chi, Cheng-Hsiang Hsiao, Lin-Hui Su
DERMATOLOGICA SINICA 32 (2014) 113–114
Staphylococcal scalded skin syndrome (SSSS) is caused by epidermolytic toxins produced by Staphylococcus aureus and characterized by blistering and superficial desquamation.1 Acute generalized exanthematous pustulosis (AGEP) is most often caused by drugs and is characterized by the rapid occurrence of many sterile, nonfollicular pustules, usually arising on an edematous erythema and often accompanied by leukocytosis and fever.2 We present a case of a 3-year boy with initial SSSS, who then develo ..................More

Hidradenitis suppurativa treated with a long-pulsed Alexandrite laserYa-Chu Tsai, Shu-Hui Wang, Po-Hsuan Lu, Tsung-Hua Tsai
DERMATOLOGICA SINICA 32 (2014) 115–117
A 19-year-old man who presented with hidradenitis suppurativa (HS) for 1 year in 2011 was healthy except for a history of being a hepatitis B carrier. Recurrent pain and discharge affected the patient's daily life. Physical examination revealed a tender, bean-sized, erythematous deep-seated nodule with suppuration (Figure 1A, arrow), and another sinus tract (Figure 1A, arrowhead) with an intermittent release of serous, purulent, or blood-stained discharge, and frequent foul odors over the left a ..................More

Somatic FGFR3 mutations in seborrheic keratosis and acanthosis nigricans of Chinese patientsGuiye Niu, Fangfang Bao, Jiabao You, Jianwen Wang, Guizhi Zhou, Hongqing Tian, Hong Liu, Furen Zhang
DERMATOLOGICA SINICA 32 (2014) 118–119
Fibroblast growth factor receptor 3 (FGFR3) is a member of the receptor tyrosine kinase family, which is involved in embryogenesis, angiogenesis, and homeostasis of multiple tissues, such as bone and lung. FGFR3 gene mutations in the germline are well-known causes of skeletal syndromes. Interestingly, the same mutations were also found as somatic mutations in various cancers and benign skin disorders, such as multiple myeloma, cervical carcinomas, and seborrheic keratosis (SK). ..................More

A case of pemphigus vegetans occurring at an unusual site and followed by gastric cancerChi-Shou Lo, Tseng-tong Kuo, Jheng-Wei Lin
DERMATOLOGICA SINICA 32 (2014) 120–121
Pemphigus is a rare autoimmune bullous disorder involving skin and mucous membrane. Pemphigus vegetans is a rare variant of pemphigus and accounts for 5% of all pemphigus cases.1 It is typically characterized by vegetating plaques on skin folds and mucous membranes. The folds involved mainly include the axillary, inguinal, perianal, submammary, and umbilical areas. The diagnosis is based on clinical, histopathological, and immunofluorescence studies. We present a case of pemphigus vegetans occur ..................More

A rare case of retroauricular Warthin's tumor in a 46-year-old manHan-Chi Tseng, Jui-Hung Ko, Rosaline Chung-Yee Hui
DERMATOLOGICA SINICA 32 (2014) 124–125
A 46-year-old Taiwanese man presented with a 4-month history of a slow-growing mass in the right retroauricular area (Figure 1). The asymptomatic, ill-defined, movable, soft, skin-colored subcutaneous nodule had a mild central depression. Apart from a 20-year habit of smoking 20 cigarettes/day, his medical history was unremarkable. An incisional biopsy under the clinical impression of an epidermal cyst was performed to confirm tumor diagnosis because of the large size of the mass. ..................More

Identification of one novel mutation of the NCSTN gene in one Chinese acne inversa familyShanshan Ma, Yongxiang Yu, Gongqi Yu, Furen Zhang
DERMATOLOGICA SINICA 32 (2014) 126–128
Acne inversa (AI; OMIM 142690) is an autosomal dominantly inherited skin disorder. Clinically, AI is characterized by painful deep-seated, inflamed lesions in the apocrine gland-bearing area of the body, especially in the axillary, inguinal, and anogenital regions. To date, three genetics regions (6q25.1–25.2, 19p12–19q12, and 1p21.1–1q25.3) have been identified by linkage analysis to be responsible for AI.1,2 A total of 21 mutations have been identified in the γ-secretase genes including ..................More

Congenital primary milium of the nippleJin Park, Joo-Ik Kim, Dae-Woo Kim, Su-Ran Hwang, Yeon-Jun Jeong, Seok-Kweon Yun
DERMATOLOGICA SINICA 32 (2014) 129–130
Milia are tiny epidermoid cysts, and are quite common at all ages from infancy onwards. Primary milia develop spontaneously, while secondary milia occur after trauma or other injury to the skin. Milia most commonly occur as multiple lesions in the areas of vellus hair follicles, and on the cheeks and eyelids in particular.1,2 However, involvement of the nipple is very rare, with only one case reported.3,4 This case report describes a child diagnosed with a congenital primary milium of the nipple ..................More