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New hope for tamoxifen-resistant breast cancer

By: Misti Crane

The Columbus Dispatch - September 05, 2012 02:19 PM

Researchers at Ohio State University's Comprehensive Cancer Center hope that a new study will
help improve treatment of breast cancer in women who don't respond well to the commonly-used drug
tamoxifen.

The researchers discovered how tamoxifen-resistant breast-cancer cells grow and multiply and say
that the information suggests that an experimental therapy might help these women.

The team looked at more than 300 human tumors and found that those that with an activated
pathway called hedgehog (Hhg) had a worse prognosis. They found that the experimental drug
vismodegib inhibits the growth of tamoxifen-resistant tumors in mice.