SUMMARY - Premature neonates requiring prolonged normobaric hyperoxygenation may develop RETROLENTAL FIBROPLASIA, BRONCHOPULMONARY DYSPLASIA, myopia, pulmonary air leaks from ALVEOLAR RUPTURE with a variety of complications, and (CONTROVERSIAL if due all or in part to hyperoxia) intracerebral hemorrhage or necrotizing enterocolitis.

HYPERBARIC HYPEROXIA -

CNS TOXICITY - Toxicity of oxygen at elevated concentrations and pressures is usually only seen in divers, personnel and patients in hyperbaric chambers, and in rescue squad members in tunnels and mines. Seizures may be seen in diving or hyperbaric chamber accidents.

OCULAR TOXICITY - In normal adult volunteers exposed at 3.0 ATA for 4 hours, a progressive contraction of the visual fields, impaired central vision, and mydriasis developed. These effects were reversible if the exposure was stopped.

Nuclear cataracts have developed during prolonged hyperbaric oxygen therapy.