Ben and Rook follow Maltruant through the time stream. Ben has an adventure with George Washington, in 1773, fighting Maltruant and Vilgax. After defeating Vilgax, Ben and Rook chase Maltruant in the time stream to the beginning of time itself onto the starship of the Contemelia (the creators of the Annihilaarg) where Maltruant attempts to create

In an alternate future timeline, Ben 10,000 and Kai Green (at this point in time, Kai Tennyson) are at Plumbers' Headquarters having a party for Grandpa Max because he is retiring from the Plumbers and Rook is being promoted to be in charge of the Plumbers until Maltruant, Exo-Skull and Subdora secretly attacks Plumbers' Headquarters to get the

Ben is being forced to be in an alien reality show called the Most Delicious Show and he watches as all the girls he'd met in his life to win the reality show's games to be the new Mrs. Tennyson. Soon, Kai Green wins the reality show, with Ester later revealing that she found another boyfriend-Sunny's old sweetheart Antonio.

Ben finally manages to rid himself of Skurd... just when he needs the Slimebiote most. Vilgax and Albedo team up to steal Malware's calcified husk to convert into a war armor for Vilgax to defeat Ben. As Ben fights Vilgax, he realizes how much he needs Skurd to help him, while Azmuth and the Galvans (Luhley, Blukic and Driba) fight Albedo. Azmuth

While Rook is stuck on graveyard shift at Plumber HQ, his sensei Kundo returns as a cyborg to purge the galaxy of technological influence. Ben and Max take a massive Plumber squadron to stop Yeta, a female Shockquach alien, from continuing her criminal destruction. They later find HQ on lockdown because of Kundo and try to break into the base to

Charmcaster traps Gwen in Ledgerdomain to exact her revenge once and for all, turning her into a stone totem. When she then attempts to take over Gwen's headquarters at Friedkin University, Ben, Kevin and Rook fight back with the aid of the great sorcerer Bezel. Charmcaster is eventually defeated and turned into a totem herself, trapped in her own

During Kai's search for the Temple of the Sky, she reluctantly teams up with Ben, Skurd, and Rook at the insistence of Kai's grandfather. As they search, Ben teases Kai about Spanner's telling them they are married in the future, and as he shows her more clues they show more attraction, despite Kai denying Spanner's prediction. Upon reaching the

Exo-Skull, Subdora and Eon attack a hidden underground cavern to retrieve a rare egg of a Time Beast. Professor Paradox and Ben 10,000 teams up with Ben and Rook to stop the Time Beast. Rook, Ben and Skurd go after the Time Beast while Ben 10,000 and Professor Paradox fight Exo-Skull and Subdora. However, a series of mistakes lead the five of them

Khyber teams up with a Slimebiote, a DNA-eating parasite, named Skurd so he can safely use the Nemetrix (which he stole from the plumber base earlier) to eliminate Ben. The plan backfires when Skurd discovers the vast amount of DNA he can consume from the Omnitrix and decides to latch onto it, to both Khyber and Ben's dismay. As Khyber goes mad

This episode is a flashback to Ben and Gwen's younger days when they were eleven. Zs'Skayr returns with a plan to have his fellow Ectonurites to possess the inhabitants of Bellwood to develop a device to permanently block out the sunlight on Earth so he can colonize the planet with more Ectonurites.