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July 30, 2014

Link Between Excess Free Radicals, Oxidative Stress and Fibromyalgia

FACTSHEET 3.0: The Link Between

Excess Free Radicals, Oxidative Stress and Fibromyalgia

and How Can C[60] Hydrated Fullerenes Help? (v2)

If you have fibromyalgia, or chronic fatigue syndrome you may want to consider drinking Carbon [60] Hydrated Fullerene Water Solution to scavenge / neutralise excess free radicals (oxidative stress) in the body that may cause fibromyalgia.

The role of free radicals in fibromyalgia is controversial. In this study, 85 female patients with primary fibromyalgia and 80 age-, height-, and weight-matched healthy women were evaluated for oxidant/antioxidant balance. Malondialdehyde is a toxic metabolite of lipid peroxidation used as a marker of free radical damage. Superoxide dismutase is an intracellular antioxidant enzyme and shows antioxidant capacity. Pain was assessed by visual analog scale. Tender points were assessed by palpation. Age, smoking, body mass index (BMI), and duration of disease were also recorded. Malondialdehyde levels were significantly higher and superoxide dismutase levels significantly lower in fibromyalgic patients than controls. Age, BMI, smoking, and duration of disease did not affect these parameters. We found no correlation between pain and number of tender points. In conclusion, oxidant/antioxidant balances were changed in fibromyalgia. Increased free radical levels may be responsible for the development of fibromyalgia. These findings may support the hypothesis of fibromyalgia as an oxidative disorder.

This is for nutritional /general information only and is not intended to diagnose, treat or cure. See your doctor for specific medical advise.

Many fullerenes with chemical tails called fullerene derivatives or functionalized fullerenes are indeed toxic but our pristine fullerenes or C[60] hydrated fullerenes discovered by Ukrainian scientists show no toxicity and no medical contra-indications after 20 years of preclinical and clinical studies. In 2012, a study at the University of Paris showed that fullerenes almost double the lifespan of rats with no toxic effects.

Safety and ToxicityMoussa et al. (1996–7)[58][59] studied the in vivo toxicity of C60 after intra-peritoneal administration of large doses. No evidence of toxicity was found and the mice tolerated a dose of 5 g/kg of body weight.

Mori et al. (2006)[60] could not find toxicity in rodents for C60 and C70 mixtures after oral administration of a dose of 2 g/kg body weight and did not observe evidence of genotoxic or mutagenic potential in vitro. Other studies could not establish the toxicity of fullerenes: on the contrary, the work of Gharbi et al. (2005)[61] suggested that aqueous C60 suspensions failing to produce acute or subacute toxicity in rodents could also protect their livers in a dose-dependent manner against free-radical damage.

In 2012, it was revealed that oral administration prolonged the lifespan of rats by nearly 100% without showing toxic effects.[62] In a more recent video interview filmed in October 2012 and placed online, Professor Moussa states that pure C60 is not toxic.[63]

A comprehensive and recent review on fullerene toxicity is given by Kolosnjaj et al. (2007).[64][65] These authors review the works on fullerene toxicity beginning in the early 1990s to present, and conclude that very little evidence gathered since the discovery of fullerenes indicate that C60 is toxic.

Studies that showed that fullerenes were toxic (2005 and 2006) proved to be flawed in design. Solvent residues in the experiments showed toxicity not the pristine fullerenes

In 2010, the Ministry of Healthcare of Ukraine approved the industrial use of Concentrate Solutions of Hydrated C60 Fullerene as an antioxidant in food, fragrance and cosmetic, biotechnological and microbiological industries. Sanitary and hygienic conclusion of Ministry of Healthcare of Ukraine No 05.03.02-04/89993 d/d November 19, 2010.