Sheffield United's summer signings John Cofie, Ryan Flynn, Matt Hill and Chris Porter will all have late fitness tests ahead of the game.
Teenage striker Cofie, a season-long loan signing from Manchester United, is one of several new Blades players hoping to make their league debuts.
"We've got a few lads who will be assessed before the game on Saturday," manager Danny Wilson told the club's official website.
"They include Matt Hill, John Cofie, Ryan Flynn and Chris Porter. They've got slight niggles and at the moment we don't know how they will respond to treatment before the weekend."
Wilson has no other injury or suspension worries, while close-season arrivals Mark Howard, Darryl Westlake, Tony McMahon, Shaun Miller and Nick Blackman, who scored in the Capital One Cup defeat to Burton last weekend, could all make their first league appearances for the Blades.
Shrewsbury look set to have a full-strength squad available after Darren Jones returned to training.
The defender mi...

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