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Penn Radio was an hour-long talk CBS radio show which ran from January 3, 2006 to March 2, 2007, hosted by Penn Jillette and Michael Goudeau and produced by "Happy" Jack Landreth and Patrick DiFazio. It was broadcast on the Free FM brand radio stations live, with theme music by Mike Jones.

The show dealt with topics in the news regarding science, skepticism, religion, entertainment and politics. Jillette promoted his libertarian and atheist perspectives from the "nut point of view" to encourage listeners to call and email with their stories and opinions about the topic. Early shows tended to be without structure, with Jillette and Goudeau talking about whatever came to mind, taking the occasional caller and reading the occasional email. Later shows had tended to formalize around a current topic and a call-in talk show format.

Jillette and Goudeau would usually broadcast from Jillette's Vegas area home ("The Slammer"). The broadcast was done from Jillette's personal recording studio, Vintage Nudes Studio.