Rothia dentocariosa is a Gram positive organism, known to cause infection very rarely in immunocompromised patients. We report isolation of Rothia dentocariosa in blood and Cerebrospinal Fluid (CSF) of an elderly patient with multiple myeloma. The present case highlights pathogenic role of an uncommon Gram positive organism. To the best of our knowledge Rothia dentocariosa is being reported for the first time from India, in an immunocompromised patient with haematological malignancy.