Drug Interaction: Calcium channel blockers and digoxin can cause lowering of blood pressure and heart rate to dangerous levels when administered together with atenolol. Atenolol can mask the early warning symptoms of low blood sugar (hypoglycemia), and should be used with caution in patients receiving treatment for diabetes.

Mechanism of Action: Atenolol is a competitive cardioselective ?1-blocker. It does not have effect on ?2-receptors except in high doses. Its cardioselectivity is dose-related. Atenolol reduces resting and exercise-induced heart rate as well as myocardial contractility. Peripheral ?-blockade may result in vasoconstriction. Atenolol reduces BP and heart rate which results in reduced myocardial work and O2 requirement leading to improved exercise tolerance and reduced frequency and intensity of anginal attack.

Pregnancy Impact: There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

Impact During Lactation: There is positive evidence of risk to a breastfed infant or to breastmilk production, but the benefits of use in breastfeeding mothers may be acceptable despite the risk to the infant (e.g. if the drug is needed in a life-threatening situation or for a serious disease for which safer drugs cannot be used or are ineffective).

Drug Interaction: Chlorthalidone can cause lowering of blood potassium and magnesium levels because both potassium and magnesium are lost in the urine. This is especially true in patients who are taking at the same time another class of diuretics, called loop diuretics such asfurosemide (Lasix), bumetanide (Bumex), or torsemide (Demadex) Low potassium and magnesium levels can lead to abnormal heart rhythms, especially in patients taking digoxin (Lanoxin). Chlorthalidone reduces the kidney's ability to eliminate lithium in the urine.

Mechanism of Action: This medication is a diuretic, prescribed for high blood pressure and fluid retention.

Pregnancy Impact: Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

Impact During Lactation: Studies in breastfeeding mothers have demonstrated that there is significant and documented risk to the infant based on human experience, or it is a medication that has a high risk of causing significant damage to an infant. The risk of using the drug in breastfeeding women clearly outweighs any possible benefit from breastfeeding. The drug is contraindicated in women who are breastfeeding an infant.

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In compliance with Drug and Cosmetic Act and Rules, we don't process requests for Schedule X and other habit forming drugs. For Schedule H and H1 drugs a valid prescription from a registered medical practitioner needs to be uploaded with Order.