KRT10

(redirected from Cytokeratin-10)

KRT10

A gene on chromosome 17q21 that encodes a type-I (acidic) member of the cytokeratin family, which belongs to the superfamily of intermediate filaments, that with actin microfilaments and microtubules forms the epithelial cell cytoskeleton.

Localization of cytokeratin-14 in the basal layer and presence of cytokeratin-10 in the supra-basal layers verified an anatomically correct differentiation of the epidermis.

Physiological differentiation was confirmed by immunohistological staining, showing a physiological location of cytokeratin-14 in the basal layer and cytokeratin-10 in the suprabasal layers (Fuchs, 2009).

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