Naphthalimides and related compounds

Naphthalimide derivatives bearing an aminoalkyl side chain such as mitonafide and amonafide have shown interesting cytotoxic activity,23 which is due to intercalation and topoisomerase II inhibition.24 Both mitonafide25 and amonafide26 have been extensively tested in clinical trials but have not been employed in therapeutics, although they have been used as leads in the design of bis-intercalators (see below).

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