Not tested in other applications. *Optimal dilutions/concentrations should be determined by the researcher.

Form Supplied

Liquid

Purification

Unpurified

Specifications: ROR1 antibody [2H6]

Full Name

receptor tyrosine kinase-like orphan receptor 1

Background

This gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway. This gene is highly expressed during early embryonic development but expressed at very low levels in adult tissues. Increased expression of this gene is associated with B-cell chronic lymphocytic leukaemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2012]