CHEMICAL CONSTITUENTS OF THE ETHYL ACETATE EXTRACT OF THE FRUIT BODIES OF PHELLINUS GILVUS

Quang Ngoc Dang

Abstract

Five fungal secondary metabolites named 1,2,4,5-tetrachloro-3,6-dimethoxybenzene (1); ergosterol (2); ergosterol peroxide (3); (E)- 4-(3,4-dihydroxyphenyl)but-3-en-2-one (4) and [Bi-1,4-cyclohexandien-1-yl]-3,3’,6,6’-tetrone, 4, 4’-dihydroxyl-2,2’,5,5’-tetramethyl (5) were purified from ethyl acetate extract of the fruit bodies of Phellinus gilvus collected at Pu Mat national park, Nghe An province. Their structures were charaterized by 1D, 2D NMR and GC-MS spectroscopies. Especially, the structure of compound 1 was confirmed by X-ray crystallographic analysis. The antimicrobial and cytotoxicity activities of compounds 1 were also evaluated. This is the first report on the chemical constituents of Vietnamese Phellinus gilvus.