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How does this medication work? What will it do for me?

Yellow fever vaccine belongs to a group of medications known as vaccines. It is used to prevent yellow fever caused by a flavivirus and passed to humans who are bitten by an infected mosquito. Infection from this virus attacks the liver and can be deadly.

The yellow fever vaccine is recommended for adults and children 9 months of age and older who are travelling to or living in areas where yellow fever exists. Vaccination is also recommended for laboratory workers who routinely handle specimens that contain or are believed to contain yellow fever. The yellow fever vaccine increases your defenses against infection by the virus by stimulating the production of your own antibodies. These antibodies remain in the body until they are needed to fight off the virus responsible for yellow fever.

Your doctor may have suggested this vaccine for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are receiving this vaccine, speak to your doctor.

How should I use this medication?

The usual dose of this vaccine is 0.5 mL given as subcutaneous (under the skin)injection. A second dose, or “booster” dose, may be given after 10 years to boost the levels of antibodies in the blood, however, evidence demonstrates that the effectiveness of the yellow fever vaccine may last for at least 30 to 35 years.

This vaccine is given by a health care professional in a doctor's office, hospital, or clinic.

It takes 10 days for immunity to develop after using this vaccine, so it is important that this vaccine be given at least 10 days before entering an area where you may come into contact with the virus that causes yellow fever.

This medication is stored in the refrigerator and should not be allowed to freeze.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Stop taking the medication and seek immediate medical attention if any of the following occur:

confusion

high fever with headache

seizures

signs of a serious allergic reaction (e.g., abdominal cramps, difficulty breathing, nausea and vomiting, or swelling of the face and throat)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking this medication.

Are there any other precautions or warnings for this medication?

Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.

Allergic reactions: As with any vaccine, allergic reactions are possible with the yellow fever vaccine. Your doctor may want you to remain in the clinic or office for a period of time after receiving the vaccine, to ensure that you do not develop an allergic reaction.

Immune system: As with any vaccine, this vaccine may not be as effective for people with a weakened immune system (e.g., people with AIDS or cancer, people taking antirejection medications after an organ transplant, people receiving chemotherapy, people taking any medication that suppresses the immune system). If you or your child has a weakened immune system, the doctor may decide to postpone the vaccine until the immune system recovers.

Infection or fever: This vaccine should not be given to anyone who has an active infection or an illness associated with fever, unless the doctor decides that the benefits outweigh the risks.

Vaccine protection: As with any vaccine, this vaccine may not protect 100% of people who receive it and may not prevent infection in those people already infected with the virus.

Pregnancy: This medication should not be used during pregnancy unless the benefits outweigh the risks.

Breast-feeding: It is not known if yellow fever vaccine passes into breast milk. If you are a breast-feeding mother and are taking this medication, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of using this medication have not been established for children less than 9 months old. Infants less than 9 months old are at an increased risk of developing encephalitis as a result of receiving this vaccine.

Seniors: People over the age of 60 may be more at risk of developing complications from this vaccine.

What other drugs could interact with this medication?

There may be an interaction between yellow fever vaccine and any of the following:

acetaminophen

belimumab

dimethyl fumarate

fingolimod

immunosuppressants (medications used to treat cancer or autoimmune disease or prevent organ rejection)

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

stop taking one of the medications,

change one of the medications to another,

change how you are taking one or both of the medications, or

leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

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Important Message

Any drug or natural health product may cause serious side effects or interactions with other medications.

Read the instructions, warnings and brochures provided by the manufacturer and consult your pharmacist when purchasing medication or natural health products carefully.

Always keep medications and natural health products out of the reach of children.

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