Dr Paul Cheney
viral pathogen toxic inherited
video
For more than 25 years, Dr. Cheney has been a pioneering clinical researcher in
the field of ME/CFS and has been an internationally recognized authority on the
subject of ME/CFS.
He has published numerous articles and lectured around the world on ME/CFS and
is author/co-author of numerous publications and scientific presentations about
ME/CFS.

Dr. Jonathan Kerrviral gene expression
Development of a diagnostic test , analysis of human and viral gene expression
in the white blood cells, and clinical trials of immunomodulatory drugs. He has
recently published research identifying distinct subtypes in patients with ME/CFS.

Dr. John Chia
70 types of entero viruses
Chronic fatigue syndrome associated with chronic enterovirus infection of the
stomach on the role of enteroviruses in the aetiolgy of ME/CFS Ė an area
which has been implicated as one of the causes by a number of studies. There are
more than 70 different types of enteroviruses that can affect the central
nervous system, heart and muscles, all of which is consistent with the symptoms
of ME/CFS. By analyzing samples of stomach tissue from 165 patients with CFS,
Dr. Chia's team discovered that 82% of these individuals had high levels of
enteroviruses in their digestive systems. Dr Chia's research may result in the
development of antiviral drugs to treat the debilitating symptoms of ME/CFS.

Dr Nancy Klimas
immune, autonomic and neuroendocrine interactions
The University of Miami CFS Research Center is exploring interactions between
the immune, autonomic and neuroendocrine.

Professor Nora Chapmaneffects of viruses upon cell function.
She and her associates have demonstrated that selection of defective enterovirus
in heart and other tissues leads to persistent infections despite active
antiviral immune responses.
Presently studying the mode of selection of these viruses and the effects of
replication of these viruses upon infected cell function.

However, certain continuity was given by the lectures of de Meirleir, Kerr, Peterson, Nicholson, and Chia, which are tied together by several
threads. These include the search for diagnostic markers, the treatment of gut
dysbiosis through diet and probiotics, and the search for complicating
pathogens, and their treatment

Neuropathology
of
post-infectious
chronic
fatigue
syndrome

Journal of
the
Neurological
Sciences
2009
(S60-S61)

Cader S.,
O'Donovan
D.G.,
Shepherd C.,
Chaudhuri A.

Abstract

Purpose: The
pathogenesis
of severe
and
relapsing
chronic
fatigue
after
viral or
bacterial
infection is
unknown.
Many
patients
with
post-infectious
chronic
fatigue,
which is
classified
as a
neurological
disease
(G93.3,
ICD-10
classification),
become
disabled and
do not
recover
fully
despite
symptomatic
and
rehabilitative
therapy.

Method: We
report here
the
histopathological
changes in
the dorsal
root
ganglia of
three female
patients
with a
diagnosis of
chronic
fatigue
syndrome.
All three
patients
were seen by
their local
physicians
and
specialists
who had
excluded
alternative
medical
cause for
their
symptoms of
disabling
fatigue and
chronic
pain. Due to
the nature
of death, a
full
autopsy
examination
was carried
out in each
of these
cases.

Results: The
most
remarkable
and
consistent
abnormality
was the
presence of
active
inflammation
with T8
lymphocytic
infiltration
in the
dorsal root
ganglion of
one patient
and evidence
of past
inflammation
(nodules of
Nageotte) in
two
patients.

Conclusion:
Dorsal root
ganglion is
the gateway
for sensory
information
reaching the
central
nervous
system.
Based on the
histopathological
changes
observed in
three cases,
we propose
that
inflammation
of the
dorsal root
ganglia
may play a
key role in
the
pathogenesis
of
post-infectious
chronic
fatigue.
Abnormal
processing
of sensory
information
secondary to
dorsal root
ganglionitiscould
potentially
contribute
to fatigue
due to
higher
perceived
effort and
pain because
of reduced
sensory
threshold.
This may
lead to new
treatment
options in a
group of
patients
that
currently
present a
significant
challenge to
neurologists.