Super-Resolution Microscopy: A Virus’ Eye View of the Cell

Institute of Immunity and Transplantation, University College London, London NW3 2PF, UK

Abstract It is difficult to observe the molecular choreography between viruses and host cell components, as they exist on a spatial scale beyond the reach of conventional microscopy. However, novel super-resolution microscopy techniques have cast aside technical limitations to reveal a nanoscale view of virus replication and cell biology. This article provides an introduction to super-resolution imaging; in particular, localisation microscopy, and explores the application of such technologies to the study of viruses and tetraspanins, the topic of this special issue. View Full-Text