George Saimes (born September 15, 1941), an All-American at defensive back and fullback for Michigan State, the Spartan MVP in 1961 and 1962 and a member of their all-time defensive team, joined the Buffalo Bills in 1963. He quickly developed into an outstanding safety and became a key member of the outstanding Bills defensive squads, which produced American Football League Championships in 1964 and 1965. In 1964 he had a career-high six interceptions and earned the first of his five American Football League All-Star Game appearances.

He achieved All-American Football League honors five times, and is a member of the Greater Buffalo Sports Hall of Fame, and the American Football League All-Time Team.