Malignant melanoma is one of the most chemoresistant malignancies in man.
Although effort is put into developing new drugs to treat metastatic melanoma, still
dacarbazine, an alkylating agent approved in 1975 for therapeutic ...

There is considerable variability in the susceptibility of smokers to develop chronic obstructive pulmonary disease (COPD). The only known genetic risk factor is severe deficiency of α1-antitrypsin, which is present in ...

Background: Addison’s disease (AD) is caused by an autoimmune destruction of the adrenal cortex. The
pathogenesis is multi-factorial, involving genetic components and hitherto unknown environmental factors. The
aim of ...

Introduction: Studies concerning vestibular schwannoma (VS) are inconsistent in
reporting of tumor size and growth. This means that results found in one paper using
one set of definitions cannot be compared directly with ...

Several new therapeutic strategies are now considered for acute myeloid leukemia (AML) patients unfit for intensive chemotherapy, including modulation of protein lysine acetylation through inhibition of histone deacetylases ...

Background:
The pathophysiological pathways resulting in Late Stent Thrombosis (LST) remain uncertain. Findings from animal studies indicate a role of the intrinsic coagulation pathway in arterial thrombus formation, while ...

Introduction:
Observational studies have reported associations between levels of the amino acid
homocysteine in the circulation and risk of cardiovascular disease. Oral
administration of the synthetic B vitamins folic ...

Coping with existential challenges is important when struck by serious disease, but apart from cancer and palliative care
little is known about how patients deal with such issues and maintain hope. To explore how patients ...

Background and objectives: Physicians are exposed to
matters of existential character at work, but little is
known about the personal impact of such issues.
Methods: To explore how physicians experience and
cope with ...

Acute myelogenous leukemia (AML) is an aggressive malignancy characterized by accumulation of
immature myeloid cells in the bone marrow. The overall disease-free survival is less than 50% even
for the younger patients ...

It is generally accepted that acute myelogenous leukemia (AML) patients are immunocompromized. On the
other hand, antileukemic immune reactivity is important for the improved survival of AML patients treated with ...

Background: A Giardia outbreak was associated with development of post-infectious functional gastrointestinal disorders (PI-FGID) and chronic fatigue syndrome (PI-CFS). Markers of immune dysfunction have given conflicting ...

Background and Aims: Recently, several genome-wide association studies have revealed that single nucleotide polymorphisms (SNPs) in proximity to IL28B predict spontaneous clearance of HCV infection as well as outcome ...

Background and Aims: Having a body mass index above or equal to 30 kg/m2 in conjunction with chronic hepatitis C virus infection is associated with non-responsiveness to treatment with interferon and ribavirin, but details ...

The gut endocrine cells control and regulate several functions of the gastrointestinal tract. They have been reported to be abnormal in irritable bowel syndrome (IBS), with alterations occurring in several functions regulated ...

Assessments of diseases are usually performed by a combination of clinical
symptoms, signs and objective measurements. Biochemical markers of inflammation
are important in evaluation of treatment of acute and chronic ...