The work of the Paduan Aristotelian philosopher Iacopo Zabarella (1533–1589) has attracted the attention of historians of philosophy mainly for his contributions to logic, scientific methodology and because of his possible influence on Galileo. At the same time, Zabarella's views on Aristotelian psychology have been little studied so far; even those historians of Renaissance philosophy who have discussed them, have based their analysis mainly on the psychological essays included in Zabarella's De rebus naturalibus , but have avoided Zabarella's commentary on Aristotle's De anima . This has led to an inaccurate, but widespread, understanding of Zabarella's views. The intention of this article is to provide a systematic analysis of Zabarella's arguments about the (im)mortality of the soul in the context of Aristotelian psychology. Zabarella's view that the soul is mortal according to Aristotle is remarkable for his time, while his elaboration of this position is far more comprehensive than that of Pietro Pomponazzi, the other significant Renaissance thinker who shared the same view.