(CNN) -- Spanish Primera Liga side Atletico Madrid have got one foot in the Champions League group stage after claiming a crucial 3-2 success at Greek side Panathinaikos in a tough qualifying round first leg encounter on Wednesday.

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Anderlecht, beaten in Champions League qualifying for the last two seasons, pulled one back through Matias Suarez in the 58th minute, but Claude Puel's Lyon side restored their four-goal advantage inside five minutes with Gomis grabbing his second of the night.

Swiss side FC Zurich took a giant step closer to playing in the competition for the first time in 28 years by claiming a 3-0 lead at Latvian side Ventspils.

Goals from Johan Vonlathen, Sylvan Aegerter and Dusan Djuriuc look almost certain to put Zurich into the last 32 of the competition.

Debrecen edged closer to becoming Hungary's first Champions League group stage participants since 1996 when they claimed a 2-1 advantage at Levski Sofia in Bulgaria.

Laszlo Bodnar gave the Hungarians the lead but Levski levelled at the start of the second period with a fine strike from Cedric Bardon. However, 14 minutes from time, Peter Czvitkovics claimed Debrecen's winner.

Israeli champions Maccabi Haifa were also winners on the road with a goal six minutes from time from substitute Shlomi Arbeitman earning a 2-1 win at Salzburg.