Dimethyltryptamin (DMT) has a long history
of use
and is found in a variety of plants and seeds. It can also be produced
synthetically. It is ineffective when taken orally, unless combined with
another
drug that inhibits its metabolism. Generally it is sniffed, smoked, or
injected.
The effective hallucinogenic dose in humans is about 50 to 100 mg and
lasts for
about 45 to 60 minutes. Because the effects last only about an hour; the
experience has been referred to as a "businessman’s trip."

A number of other hallucinogens have very similar structures and
properties to those of DMT. Diethyltryptamine (DET), for example, is an
analogue
of DMT and produces the same pharmacological effects but is somewhat
less potent
than DMT. Alpha-ethyltryptamine (AET) is another tryptamine hallucinogen
added
to the list of Schedule I hallucinogens in 1994. Bufotenine
(5-hydroxy-N-N-dimethyltryptamine) is a Schedule I substance found in
certain
mushrooms, seeds, and skin glands of Bufo toads. In general, most
bufotenine
preparations from natural sources are extremely toxic.
N,N-Diisopropyl-5-methoxytryptamine (referred to as Foxy-Methoxy) is an
orally
active tryptamine recently encountered in the United States.