It has been hypothesized that transthyretin (TTR) amyloidosis may progress after orthotopic liver transplantation (OLT) as a result of continued amyloid fibril synthesis and deposition from normal TTR. To test this hypothesis amyloid fibrils were isolated from cardiac tissues of three patients who died 1½ to 5½ years after OLT: two with Val30Met and one with Thr60Ala TTR. The ratio of variant to normal TTR in each case was determined and compared with the ratio of variant to normal in cardiac tissues from seven patients who died with TTR amyloidosis but who had not had liver transplantation. …

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JAAPA-Journal of the American Academy of Physicians Assistants;
February 1, 2005

By
Dedmon, Mark;
700+ words

KEY POINTS in this article * Liver transplant has a survival rate of from 85.9% in the first year to 77.5% in the third year posttransplant. * Liver transplant complications include postoperative complications, rejection, complications of immunosuppressive therapy, and recurrence of disease. *…