Safe maybe. Wise no. Cocked and locked would be my choice. They were designed to run on hardball so you may have to do some work to get it to shoot HP reliably. That may not be a bad thing after looking at ballistic gel tests. Fiochi is the only one I have found after looking at a lot of tests that will penetrate more than 8"-10".

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Patron Member NRA
"I would not be an old man if I had not been an armed young man." JTJ
I was taught to respect my elders but they are getting harder to find.

Only owed (briefly) one gun that ever had a decocker. First time that sucker dropped the hammer I about **** myself. If I get too nervous about dropping the hammer (the old fashioned way) on a loaded chamber, I'll just take a shot of whiskey first to steady my nerves.