Our interests center on the molecular
mechanisms by which signal transduction pathways are organized into
specialized membrane domains. In addition to their known role in
organizing receptors and downstream effectors into functional signaling
complexes, such organized complexes function to integrate signaling
activities from multiple pathways and to segregate simultaneous
but distinct functions of a single pathway. We study this question
in Drosophila because of the utility of this system for studying
the functions of individual genes via mutagenesis, and for examining
the functional interactions between different genes that work together
in a particular cellular or developmental process.