With more than one million page views and more than 4,000 items, this blog provides news and commentary on public policy, business and economic issues related to the $3 billion California stem cell agency, officially known as the California Institute for Regenerative Medicine(CIRM). David Jensen, a retired California newsman, has published this blog since January 2005. His email address is djensen@californiastemcellreport.com.

Thursday, July 31, 2014

Randy
Mills, the new president of the $3 billion California stem cell agency, rewrote
some of the agency’s history last week and extended the life span of the now nearly
10-year-old enterprise.

All that
talk about the agency running out of money for new awards in 2017? Bushwa, he
basically said. “It’s simply not true,” he told the directors of the agency at
their meeting in Millbrae.

Mills' comments
appeared to be directed at media stories, including those on this Web site,
that mention the 2017 timetable. However, the date was not concocted by the
writers of those stories. It came directly from the agency itself, which has never challenged it until Mills did last week. The
timetable was even referenced as recently as December 2013 by the agency’s
directors.

Randy Mills

That
said, Mills’ view of the spending possibilities for the California Institute
for Regenerative Medicine(CIRM), as the agency is formally known, is not inaccurate. It comes from
his fresh, business-oriented analysis of the agency’s finances. It is based on different assumptions than those used previously
by the agency. His perspective does not appear to assume, for example, that all the grant rounds approved in concept by the
board will go forward at their existing levels.

A case
in point came last week when Mills recommended and the board approved slicing
$5 million out of a $15 million component of the agency’s Alpha clinic RFAs. It was the first time that the board has so heavily cut a previously approved "concept" figure.

“We now
find ourselves with the reality that, having started with $3 billion, we are
down now to how to deploy our last $600 million….”

Pat
Olson, executive director of scientific activities, said,

“There’s
essentially $950 million yet to be awarded, 321 (million) of the concept
approved and the 629 (million) of the future.”

Steve Juelsgaard

Steven
Juelsgaard, a CIRM board member and former executive vice president of Genentech, however, looked at the numbers
with basically the same view as Mills. Juelsgaard, who has been chipping away
at some of the financial assumptions of the agency, said,

“So we’ve
been talking for the longest time as if we have three to four years worth of
money to spend, right? I asked myself, well, why is that true? Who made that
decision that it’s three to four years? That length of time is driven by how
quickly we spend our money, not by anything else. So if we spend our money more
slowly, we could go for six years or eight years or whatever the number is that
you want to pick. It’s all a matter of burn rate.”

Enter
Mills five months later as president. By last week, he was telling board
members that, yes, they have enough money to give out awards until 2020 at a
rate of $190 million a year. He said
that about $1 billion is available.

“We will
be able to fund most anything that meets our criteria.”

Of course,
if the agency spends more than $190 million a year, the money will run out
faster. And the agency is engaged in
clinical trials and commercialization efforts, which are far more expensive
than basic research.

But
Mills’ 2020 timetable has some significant advantages even if it slows the pace
of awards. It gives the agency substantially more time to arrange some sort of
financing for the future. Currently its only real source of funding is state
bonds. Its ability to authorize those bonds ends in 2017, according to
the agency. Currently Thomas is examining the possibility of some sort of
private-public financing arrangement. Asking voters to approve another bond
measure has not been ruled out, but it could be problematic politically. The additional time would improve the
possibility that clinical trial results would emerge that would resonate with the
public as well as with private funding sources.

While
Mills paints a rosier financial picture than the agency previously offered, he also has demonstrated a clear fondness
for focused austerity. It fits with the mood of the board. Juelsgaard, who is
chairman of the agency’s Finance Subcommittee, is also attempting to bring a sharper
financial perspective to the agency at a time when directors are clearly
feeling a pinch.

Gone are
the days when $120
million was added with modest discussion to one round of grants. No
longer is the governing board throwing another $23 million at already hefty
efforts to lure stem cell stars to California labs.

Instead last
December, after directors were told that only $629 million out of $3 billion
was left uncommitted, CIRM Director Jeff Sheehy, in a comment echoed in
tone by other board members, said,

“I just
think all of us are starting to get concerned about the burn rate. We’re just
flying through the money.”

One of
Mills’ first public actions involved the agency’s $17 million annual
operational budget, which is limited by state law. On top of those limitations,
in May he whittled the spending plan down to the point where it could be
described as less than the previous fiscal year, given inflation.

Also in
May, when directors were considering elimination of what was left of the $57
million researcher recruitment program, Mills basically disengaged himself from
support of the effort. He told directors,

“It’s
not that I don’t like the concept of recruiting great people….It’s just we have
to make sure we recruit the people we need.”

Mills' actuarial exercise was not the first involving CIRM's mortality. Back in 2004, it was widely believed that the agency had only a 10-year life, a belief held by some of its staffers, which would have meant this year would have been the agency's last. That misconception grew out of the agency's 10-year authorization to issue bonds. That authorization is now commonly believed to have begun in 2007 because that was the year litigation about the agency was ultimately resolved. It may well be that the date of CIRM's final reckoning will change once again before its last check goes out the door.

About Me

The California Stem Cell Report is the only nongovernmental website devoted solely to the $3 billion California stem cell agency. The report is published by David Jensen, who worked for 22 years for The Sacramento Bee in a variety of editing positions, including executive business editor and special projects editor. He was the primary editor on the 1992 Pulitzer Prize-winning series, "The Monkey Wars" by Deborah Blum, which dealt with opposition to research on primates. Jensen served as a press aide in the 1974 campaign and first administration of Gov. Jerry Brown. (Time served: two years and one week.) He writes from his sailboat on the west coast of Mexico with occasional visits to land. Jensen began writing about the stem cell agency in 2005, noting that it is an unprecedented effort that uniquely combines big science, big business, big academia, big politics, religion, ethics and morality as well as life and death. The California Stem Cell Report has been identified as one of the best stem cell sites on the Internet. Its readership includes the media (both mainstream and science), a wide range of academic/research institutions globally, the NIH and California policy makers.