Chronic recurrent multifocal osteomyelitis is a rare, autoinflammatory, immunological disorder. Aseptic osteomyelitis may be associated with recurrent inflammatory bone pain. Incase of a delay in diagnosis, persistent symptoms or joint damage has a negative impact on the quality of life. Here in we report a 16-year-old male patient who has presented with left hip and right knee pain for two months and diagnosed as chronic recurrent multifocal osteomyelitis. Improvement was achieved with prednisolone and methotrexate treatments initiated upon failure to respond to ibuprofen therapy. Chronic recurrent multifocal osteomyelitis should be considered in the differential diagnosis of the patients presenting with joint compalints and having radiological bone lesions with no microorganisms and without the response to antibiotic therapy.