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In a heated moment during her Benghazi testimony on Wednesday, the secretary of state lost her cool and hollered her response following a series of questions posed by Republican Sen. Ron Johnson of Wisconsin.

“With all due respect, the fact is we have four dead Americans. Was it because of a protest or was it because of guys out for a walk one night who decided they’d go kill some Americans,” Clinton shouted during the hearing. “What difference at this point does it make?”

CNN host Anderson Cooper on Wednesday night asked Tapper whether or not the hearing would have any impact on her future political career, especially if she decided to run for president in 2016.

“I think that the quote of hers that you just played, ‘What difference does it make at this point?’ is ready for a campaign commercial,” Tapper said.

“I think that will be used against her and certainly it comes across as more glib than I think — if she could go back and revise and extend those remarks she would have,” he added.

The footage could be used by a Republican opponent like Gov. Chris Christie or even by a Democrat like current Vice President Joe Biden, according to Tapper.