DesOwen

"What are allergies?

Allergies occur when the body's immune system responds to a substance it considers an "invader." Substances that provoke the immune system into an allergic response are known as allergens. There is no such thing as a"...

DesOwen

CLINICAL PHARMACOLOGY

Like other topical corticosteroids, desonide has anti-inflammatory, antipruritic
and vasoconstrictive properties. The mechanism of the anti-inflammatory activity
of the topical steroids, in general, is unclear. However, corticosteroids are
thought to act by the induction of phospholipase A2 inhibitory proteins,
collectively called lipocortins. It is postulated that these proteins control
the biosynthesis of potent mediators of inflammation such as prostaglandins
and leukotrienes by inhibiting the release of their common precursor arachidonic
acid. Arachidonic acid is released from membrane phospholipids by phospholipase
A2.

Pharmacokinetics: The extent of percutaneous absorption of topical corticosteroids
is determined by many factors including the vehicle and the integrity of the
epidermal barrier. Occlusive dressings with hydrocortisone for up to 24 hours
have not been demonstrated to increase penetration; however, occlusion of hydrocortisone
for 96 hours markedly enhances penetration. Topical corticosteroids can be absorbed
from normal intact skin. Inflammation and/or other disease processes in the
skin may increase percutaneous absorption.

Studies performed with DesOwen® (desonide cream, ointment and lotion) Cream,
Ointment, and Lotion indicate that they are in the low to medium range of potency
as compared with other topical corticosteroids.

Last reviewed on RxList: 8/11/2008
This monograph has been modified to include the generic and brand name in many instances.