Previous GeneCards Identifiers for NELL1 Gene

Summaries for NELL1 Gene

Entrez Gene Summary for NELL1 Gene

This gene encodes a cytoplasmic protein that contains epidermal growth factor (EGF)-like repeats. The encoded heterotrimeric protein may be involved in cell growth regulation and differentiation. A similar protein in rodents is involved in craniosynostosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]

GeneCards Summary for NELL1 Gene

NELL1 (Neural EGFL Like 1) is a Protein Coding gene.
Diseases associated with NELL1 include Craniosynostosis and Gnathodiaphyseal Dysplasia.
GO annotations related to this gene include calcium ion binding.
An important paralog of this gene is NELL2.

Graphical View of Domain Structure for InterPro Entry

No data available for
Gene Families and
UniProtKB/Swiss-Prot
for NELL1 Gene

Function for NELL1 Gene

Products:

Molecular function for NELL1 Gene

GENATLAS Biochemistry:

chicken nel-like 1 homolog with a wide and weak expression,preferentially expressed in cranial intramembranous bone and neural tissues (upregulated during unilateral premature closure of the corneal suture) transciently also expressed in hematopoietic cells during pre B cell development and in adult and fetal brain,potentially playing an oncogenic role in these cells