The phase 3 trial included more than 2,000 patients with mild dementia from Alzheimer's who took either the drug solanezumab or a placebo. Those who took the drug did not have slower mental decline than those who took the placebo, BBC News reported.

Data released last year suggested the drug had promise. Drug maker Lilly designed solanezumab to target accumulation of amyloid protein, which forms sticky plaques in the brain of people with Alzheimer's.

The trial results "were not what we had hoped for and we are disappointed for the millions of people waiting for a potential disease-modifying treatment for Alzheimer's disease," said John Lechleiter, chief executive of Lilly, BBC News reported.

There are several experimental drugs that target amyloid, but solanezumab was at the most advanced stage of development, BBC News reported.

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No Active Zika Transmission in North Miami Beach: CDC

The North Miami Beach area is not longer classified as an area of active Zika virus transmission, the U.S. Centers for Disease Control and Prevention said Tuesday.

There have been no new cases of local Zika transmission in the area for more than 45 days, which suggests that the risk of infection there is no longer higher than in the rest of Miami-Dade County.

South Miami Beach will remain classified as an area of active Zika virus transmission (red zone) until 45 days pass without new cases, the CDC said.

"At this time, we are removing the red zone from North Miami Beach area but continuing the red zone for South Miami Beach. This means that we still advise pregnant women not to travel to the red zone in South Miami Beach," CDC Director Dr. Tom Frieden said in an agency news release.

"Furthermore, people living in or visiting Miami-Dade County, including Miami Beach, particularly pregnant women, are still encouraged to continue to take steps to prevent mosquito bites and to follow guidelines for preventing sexual transmission. We cannot let down our guard," he added.

As of November 16, there had been 4,255 cases of Zika reported in the continental United States and Hawaii, included 139 locally transmitted mosquito-borne cases in Florida, 35 cases believed to be caused by sexual transmission, and one case that was the result of a laboratory exposure, according to the CDC.