Protein translocase subunit SecY ; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (451 aa)

0.479

hisH

ImGP synthase subunit HisH ; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (211 aa)

a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1

node2

node1 accession

node2 accession

node1 annotation

node2 annotation

score

RB2654_03919

RB2654_10129

RB2654_03919

RB2654_10129

Inosine-5’-monophosphate dehydrogenase

Predicted hydrolase (Haloacid dehalogenase (HAD) superfamily protein)

0.847

RB2654_03919

RB2654_10144

RB2654_03919

RB2654_10144

Inosine-5’-monophosphate dehydrogenase

Possible oxidoreductase Short-chain dehydrogenase/reductase SDR

0.459

RB2654_03919

RB2654_20603

RB2654_03919

RB2654_20603

Inosine-5’-monophosphate dehydrogenase

Ser/Thr protein phosphatase/nucleotidase, putative

0.984

RB2654_03919

guaA

RB2654_03919

RB2654_03554

Inosine-5’-monophosphate dehydrogenase

Glutamine amidotransferase ; Catalyzes the synthesis of GMP from XMP

0.999

RB2654_05842

RB2654_10129

RB2654_05842

RB2654_10129

Aminotransferase, DegT/DnrJ/EryC1/StrS family protein

Predicted hydrolase (Haloacid dehalogenase (HAD) superfamily protein)

0.496

RB2654_05842

guaA

RB2654_05842

RB2654_03554

Aminotransferase, DegT/DnrJ/EryC1/StrS family protein

Glutamine amidotransferase ; Catalyzes the synthesis of GMP from XMP

0.459

RB2654_05842

hisH

RB2654_05842

RB2654_06274

Aminotransferase, DegT/DnrJ/EryC1/StrS family protein

ImGP synthase subunit HisH ; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR

ATP-dependent Clp protease adapter protein ClpS ; Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation

0.670

RB2654_10129

guaA

RB2654_10129

RB2654_03554

Predicted hydrolase (Haloacid dehalogenase (HAD) superfamily protein)

Glutamine amidotransferase ; Catalyzes the synthesis of GMP from XMP

0.842

RB2654_10129

hisH

RB2654_10129

RB2654_06274

Predicted hydrolase (Haloacid dehalogenase (HAD) superfamily protein)

ImGP synthase subunit HisH ; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR

0.479

RB2654_10129

secY

RB2654_10129

RB2654_11033

Predicted hydrolase (Haloacid dehalogenase (HAD) superfamily protein)

Protein translocase subunit SecY ; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently

0.479

RB2654_10139

RB2654_10129

RB2654_10139

RB2654_10129

Possible ribosomal RNA small subunit methyltransferase C RsmC

Predicted hydrolase (Haloacid dehalogenase (HAD) superfamily protein)

0.667

RB2654_10139

RB2654_10144

RB2654_10139

RB2654_10144

Possible ribosomal RNA small subunit methyltransferase C RsmC

Possible oxidoreductase Short-chain dehydrogenase/reductase SDR

0.775

RB2654_10139

clpS

RB2654_10139

RB2654_10134

Possible ribosomal RNA small subunit methyltransferase C RsmC

ATP-dependent Clp protease adapter protein ClpS ; Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation

0.893

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Network Stats

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Functional enrichments in your networkNote: some enrichments may be expected here (why?)

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Statistical background

For the above enrichment analysis, the following statistical background is assumed: