Week 13, 2003: Patriots 38, Colts 34

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In 2002, the Colts moved to the newly formed AFC South, and it would be more than two years between the second and third time Brady and Manning met.

In their third matchup, Manning played very well at home against the Pats. According to ESPN Stats and Information, the game marked the first time a quarterback had ever thrown four touchdown passes against the Patriots while under Bill Belichick.

However, it was all for naught. The Colts couldn't convert a 1st-and-goal from the 2-yard line with less than a minute left. Brady and the Patriots left town with a 38-34 win, and Manning was left still searching for his first win over Brady.

Week 1, 2004: Patriots 27, Colts 24

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After losing to Brady and the Patriots in the AFC Championship Game, then watching those same Patriots down the Carolina Panthers in Super Bowl XXXVIII, Peyton Manning and the Colts didn't have to wait long for a rematch.

The two teams met again to kick off the following season, but the only thing that had changed was the date on the calendar.

Once again it was the Patriots who came up with the win, propelled to victory by 335 passing yards from Brady and another late goal-line stand from the New England defense.

Week 9, 2006: Colts 27, Patriots 20

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2006 marked the second of three straight seasons in which Week 9's slate was headlined by a matchup between Brady's Patriots and Manning's Colts.

For once, it was the Colts riding a wave of momentum into the game. Not only had Manning and the Colts won the previous meeting between the two teams, but Indy rolled into New England that week undefeated. It left the same way.

Behind 326 passing yards and two scores from Manning, the Colts downed the Patriots, 27-20.

For Brady, his zero-touchdown, four-interception game (one of only two in his career, per ESPN) was among the worst performances of his 14 NFL seasons.

Week 9, 2007: Patriots 24, Colts 20

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If the 2006 AFC Championship Game is the high point of the rivalry between Manning and Brady from an excitement perspective, then their next meeting may have been the most anticipated—at least in the week leading up to the game.

The defending Super Bowl champion Colts were playing host to an undefeated Patriots team. With three straight wins over Brady and the Pats, Manning had a chance to really tip the scales of this rivalry in his favor.

Alas, it was not to be.

The Patriots notched a 24-20 win, en route to becoming the only team in NFL history to post a 16-0 record in the regular season.

Week 10, 2009: Colts 35, Patriots 34

The Colts and Patriots did play one another in 2008, but Matt Cassel played in place of Brady, who suffered a season-ending knee injury in Week 1.

It was that hypothetical tree in the forest. It fell. No one heard.

In 2009, however, Brady and Manning were back at it, combining for more than 700 passing yards and seven touchdowns in a good old-fashioned shootout.

Up six with little more than two minutes to go, the Patriots failed to convert on a fourth-down play from their own 28-yard line. That gave Manning a short field to deal with, and his touchdown pass to Reggie Wayne completed a big fourth-quarter comeback to give the Colts a 35-34 win.

The game was Indy's 18th straight regular-season win and moved the Colts to 9-0 on the season.

Week 11, 2010: Patriots 31, Colts 28

The venue may have been different the next time Brady and Manning met in 2010, but just like the game in 2009, Manning had a huge performance.

He threw for 396 yards and four scores. And just like in the game in 2009, Manning and the Colts were left staring at a 17-point deficit in the fourth quarter.

However, unlike the previous year, Manning's late-game heroics would come up short. He drove the Colts deep into Patriots territory, but his third interception of the day with less than a minute left was the last nail in a 31-28 Colts coffin.

Week 5, 2012: Patriots 31, Broncos 21

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The first game between Brady and Manning since Manning joined the Denver Broncos wasn't exactly a game.

Last year's win by the Patriots was all New England, especially early on. Despite the fact that Brady threw for only 223 yards and a touchdown in the game, the Patriots raced out to a 31-7 lead and never looked back, winning 31-21.

Manning, who threw for 337 yards and three touchdowns in defeat, has lost only twice in 22 games since that day.