As we approach the end of 2016, for good or ill, this time of year lends itself to reflection. To look back over these 12 months in research at Children’s Hospital of Philadelphia, we’ve decided to pick 12 of the most popular stories we’ve brought you in the past year.

Pediatric cancer researchers at The Children’s Hospital of Philadelphia believe they have succeeded in their search for a powerful next-generation drug for neuroblastoma tumors with mutations in the anaplastic lymphoma kinase (ALK) gene associated with the cancer.