My experience, so far, with GpuGrid is all the processing has been on Nvidia GPU's which you can run on much smaller motherboard combinations. But if you are interested in lots of cpu-based computation this is certainly one solution.

This project benefits from extremely fast single thread performance, even a dual core would suffice perfectly fine. I have a 6700k @ 4.5ghz that I disabled 2 cores to save power and even with SWAN_SYNC on it only uses 25% of my CPU with only 2 cores. Since this project bounces many operations off the CPU before being able to calculate them on the GPU, a system with more cores at a lower frequency is actually detrimental to performance, which in my opinion is bollocks. Hopefully the next application they decide to use will be multithreaded.