Abstract

Purpose of Review

Regardless of the familial linkage reported in pre-eclampsia development, understanding the polymorphic genes associated with pre-eclampsia remains limited. Hence, this review aims to outline the main genetic factors that have been investigated in respect to pre-eclampsia development.

Recent Findings

It is apparent that different genes show significance in varying populations. Notably, it is reported that apolipoprotein-1 gene polymorphisms are associated with pre-eclampsia development in an African-American population, which may be worthwhile to investigate in a Black South African cohort.

Summary

Despite the research attention that is focused on this surreptitious syndrome, a definitive cause eludes scientists and physicians, alike. Genetic studies can fulfil a dual purpose of suggesting novel hypotheses through genome-wide screening and testing these hypotheses via candidate gene studies. However, publications to date have only presented inconsistent and conflicting results regarding candidate gene analysis.

• Republic of South Africa. Department of Health. Saving mothers 2014–2016: seventh triennial report on confidential enquiries into maternal deaths in South Africa: executive summary. National Department of Health; 2014–2016. This report provides the current morbidity and mortality rates of mothers and babies in South Africa.Google Scholar