A preview of the AFC divisional-round matchup between the Indianapolis Colts and Kansas City Chiefs

When: Saturday, Jan. 12, 4:35 p.m. ET

Where: Arrowhead Stadium in Kansas City, Mo.

Channel: NBC

Line: Chiefs by 6

Injuries: Two significant contributors, receiver Ryan Grant and defensive end Tyquan Lewis, missed Indianapolis’ wild-card victory against the Texans. Grant, who started 10 games in the regular season, battled a toe injury and didn’t practice all week. And Lewis, a starting defensive end, suffered a knee injury in the regular-season finale and also did not practice. Reserve safety Mike Mitchell suffered a calf strain in the wild-card game and was later ruled out. The good news is that talented young safety Malik Hooker left the Houston game with a foot injury but later returned.

For Kansas City, the first-round bye couldn’t have come at a better time. Safety Eric Berry, the heart of the Chiefs' defense, made his season debut in Week 15 and played the following game, but he sat out the season finale with a calf injury. Coach Andy Reid said the injury was bothering Berry, so the team pulled back on his participation. If Berry can’t go, his absence will be a huge blow for the Chiefs. Running back Spencer Ware has missed the last three games with hamstring and shoulder injuries. Linebacker Reggie Ragland (hip) and nose tackle Derrick Nnadi (concussion) both exited the regular-season finale.

THREE THINGS TO KNOW

1. QB play: Fans of potent offenses should be salivating. This matchup features the favorite for league MVP in Chiefs quarterback Patrick Mahomes and the seeming choice for comeback player of the year in Colts quarterback Andrew Luck. In the regular season, the two combined for 9,690 passing yards and a stunning 89 passing scores. But both also had issues with interceptions. Luck tied for second most with 15, while Mahomes tied for ninth most with 12.

2. Strength on strength: This matchup pits an Indianapolis offensive line that gave up the fewest sacks in the NFL (18) against one of the league's most prolific pass rushes, the Chiefs tying for first with 52 sacks. Against the Texans, the Colts offensive line didn’t allow a sack of Luck and gave up just four QB hits. And when Luck has time to throw, he can pick apart opposing defenses. Generating pressure in Luck’s face will be key for a Kansas City defense that ranked second-to-last in passing yards allowed.

3. Elements of familiarity: Though Colts coach Frank Reich never served as an assistant under Chiefs coach Andy Reid, there should be plenty of overlap and familiarity between staffs. That’s because Eagles coach Doug Pederson, whom Reid closely mentored as a player and coach, was Reich’s boss in Philadelphia from 2016-17. Reich has indicated how influential Pederson has been in his own rise in becoming an NFL head coach, and Reid’s fingerprints are all over the scheme Pederson and Reich ran while both worked in Philly. Reich has incorporated much of that in Indianapolis. That shared knowledge could be instrumental for both staffs in trying to craft a defensive game plan.

And though it was four years ago and there are only a handful of players remaining on both teams from the matchups, the last time these two faced in the postseason produced a memorable outcome. The Colts dealt Reid and the Chiefs a 45-44 loss in a 2013 wild-card game after Kansas City held a 28-point second-half lead. It was the second-worst collapse in postseason history. The only one worse was when the Oilers blew a 32-point lead in a 1993 wild-card game against the Bills, who were – coincidentally – quarterbacked by Reich.

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Chicago Bears strong safety Adrian Amos (38) celebrates with defensive back Sherrick McManis (27) after an interception against the Philadelphia Eagles in the first half of a NFC Wild Card playoff football game at Soldier Field. Mike Dinovo, USA TODAY Sports

Los Angeles Chargers quarterback Philip Rivers (17) celebrates while leaving the field after the Chargers' game against the Baltimore Ravens in a AFC Wild Card playoff football game at M&T Bank Stadium. Geoff Burke, USA TODAY Sports

Los Angeles Chargers running back Austin Ekeler (30) catches a pass during the second quarter against the Baltimore Ravens in a AFC Wild Card playoff football game at M&T Bank Stadium. Tommy Gilligan, USA TODAY Sports

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Los Angeles Chargers celebrate in the end zone after safety Adrian Phillips (31) second quarter interception against the Baltimore Ravens in a AFC Wild Card playoff football game at M&T Bank Stadium. Tommy Gilligan, USA TODAY Sports

Los Angeles Chargers quarterback Philip Rivers (17) changes the play at the line during thew first quarter against the Baltimore Ravens in a AFC Wild Card playoff football game at M&T Bank Stadium. Tommy Gilligan, USA TODAY Sports

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Indianapolis Colts cornerback Kenny Moore (23) reacts after an interception against the Houston Texans in the first half in a AFC Wild Card playoff football game at NRG Stadium. Troy Taormina, USA TODAY Sports

Houston Texans nose tackle Brandon Dunn (92) reacts after intercepting a pass against the Indianapolis Colts in the first half in a AFC Wild Card playoff football game at NRG Stadium. Thomas Shea, USA TODAY Sports

Indianapolis Colts quarterback Andrew Luck (12) drops back to pass against the Houston Texans in the first quarter in a AFC Wild Card playoff football game at NRG Stadium. Thomas Shea, USA TODAY Sports