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Description

Overview

A selective, cell-permeable, irreversible, slow, tight-binding inhibitor of inducible nitric oxide synthase (iNOS; Kd = 7 nM). Suitable for use in both in vitro and in vivo systems. Has a protective effect against cerebral ischemia by reducing ischemic lesion volumes. Exhibits greater than 5000- and 200-fold potency against human iNOS relative to eNOS and nNOS, respectively, and greater than 1000-fold potency against rat iNOS relative to eNOS.

Brochure

Citations

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision

04-April-2011 RFH

Synonyms

N-(3-Aminomethyl)benzylacetamidine, 2HCl

Description

A selective, irreversible, slow, tight binding inhibitor of inducible nitric oxide synthase (iNOS, Kd = 7 nM) both in vitro and in vivo. Has a protective effect against cerebral ischemia by reducing ischemic lesion volumes. Exhibits greater than 5000- and 200-fold potency against human iNOS relative to eNOS and nNOS, respectively, and greater than 1000-fold potency against rat iNOS relative to eNOS.

Form

White solid

Intert gas (Yes/No)

Packaged under inert gas

CAS number

214358-33-5

Chemical formula

C₁₀H₁₅N₃ · 2HCl

Structure formula

Purity

≥95% by HPLC

Solubility

Methanol (5 mg/ml) or H₂O (1 mg/ml)

Storage

-20°CHygroscopic

Do Not Freeze

Ok to freeze

Special Instructions

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable up to 3 months at -20°C.