Genotoxic damage in Maras powder consumers from Kahramanmaras province of Turkey
Dönbak, L.; Celik, M.; Demirhan, I.; Nagas, S.
2007-05-24 00:00:00
In the present study, chromosomal aberrations (CAs) and micronucleus (MN) levels in the lymphocytes from 60 male individuals consisting of 40 habitues of Maras powder (a kind of smokeless tobacco) and 20 unexposed subjects were determined to investigate the possible inducing effect of Maras powder. The consumers of Maras powder had no exposure to any other known mutagens or toxicants. The mean exposure period to Maras powder was 12.25 ± 0.93 years (range 3–22). Data obtained from microscopic examination of the slides was analyzed using SPSS (10.0) software package. Mean frequency of CA and MN was found to be significantly higher in Maras powder consumers as compared to controls. Similarly, there was a significant elevation in the level of aberrant cells (Ab.Cells) with CAs and binucleated cells with MN (BNMN) in habitues. Spearman’s rho correlation analysis indicated a significant increase in the frequency of CA and MN with increase in both age and years of exposure in consumers. Our finding of a significant elevation of CA and MN frequencies in peripheral lymphocytes from smokeless tobacco consumers demonstrated a potential cytogenetic hazard associated with Maras powder exposure.
http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.pngRussian Journal of GeneticsSpringer Journalshttp://www.deepdyve.com/lp/springer-journals/genotoxic-damage-in-maras-powder-consumers-from-kahramanmaras-province-Tdbq0pAR0d

Abstract

In the present study, chromosomal aberrations (CAs) and micronucleus (MN) levels in the lymphocytes from 60 male individuals consisting of 40 habitues of Maras powder (a kind of smokeless tobacco) and 20 unexposed subjects were determined to investigate the possible inducing effect of Maras powder. The consumers of Maras powder had no exposure to any other known mutagens or toxicants. The mean exposure period to Maras powder was 12.25 ± 0.93 years (range 3–22). Data obtained from microscopic examination of the slides was analyzed using SPSS (10.0) software package. Mean frequency of CA and MN was found to be significantly higher in Maras powder consumers as compared to controls. Similarly, there was a significant elevation in the level of aberrant cells (Ab.Cells) with CAs and binucleated cells with MN (BNMN) in habitues. Spearman’s rho correlation analysis indicated a significant increase in the frequency of CA and MN with increase in both age and years of exposure in consumers. Our finding of a significant elevation of CA and MN frequencies in peripheral lymphocytes from smokeless tobacco consumers demonstrated a potential cytogenetic hazard associated with Maras powder exposure.

Journal

Russian Journal of Genetics
– Springer Journals

Published: May 24, 2007

Recommended Articles

Loading...

References

Smokeless Tobacco and Health in India and South Asia

Grupta, P.C.; Ray, C.S.

Smokeless Tobacco and Related Nitrosamines

Cogliano, V.; Straif, K.; Baan, R.

Smokeless Tobacco and Oral Cancer: A Review of the Risks and Determinants