Alzheimer's Drug Repairs Brain Damage After Alcohol Binges In Rodents

A drug used to slow cognitive decline in Alzheimer’s disease could offer clues on how drugs might one day be able to reverse brain changes that affect learning and memory in teens and young adults who binge drink.

In a study led by Duke Health, scientists demonstrate in rats that a short duration of the drug donepezil can reverse both structural and genetic damage that bouts of alcohol use causes in neurons, or nerve cells, in the young brain.

There is limited research on the extent to which alcohol effects the developing brain in teens and adolescents, but it’s evident that drinking during adolescence causes changes in the brain. Much of the research has looked specifically at the hippocampus, which is linked to learning and memory. Whether those changes are permanent is unknown.