There is evidence suggesting the acceptability and feasibility of mindfulness-based intervention for people with psychosis but little is known regarding the daily integration and use of these strategies. This study aims to explore participants’ experience of daily mindfulness practice and to investigate the influence of practice level on the intervention’s efficacy. More particularly, quantitative and qualitative data were collected from six participants who completed an eight weeks compassion, acceptation and mindfulness individual therapy. The participants provided daily practice diaries, and, on a weekly basis, filled-out emotional regulation, experiential avoidance and mindfulness questionnaires. They also attended a semi-structured interview at the end of the therapy. The results suggest the acceptability and feasibility of the intervention and a certain influence of practice level on the outcomes. Even if not statistically significant, the association between practice level and emotional regulation and experiential avoidance are clinically significant. Also, data suggest that the issues and needs inherent to the daily practice of mindfulness were specific to each participant. It brings light the importance for the therapist to be flexible in the delivery of mindfulness abilities and the necessity to adapt treatment protocols to each participant.