Addition of NT-proSST to the updated FRS as continuous variable led to an integrated discrimination improvement of 0.004 (95% CI: 0.002– 0.007; P < 0.001) for the 10-year risk of CVD (correct reclassification of 2.5%).

The addition of hsTNT or NT-proBNP into the FRS improved the c-index from 0.785 (95% CI: 0.770–0.800) to 0.796 (95% CI: 0.781–0.812; P for difference <0.001) or 0.787 (95% CI: 0.770–0.802; P for difference <0.001), respectively.

Conclusion

NT-proSST concentrations were associated with an increased risk of incident CVD and all-cause mortality, after adjusting for traditional CVD risk factors and emerging biomarkers, in a population-based cohort of men and women without a history of CVD. These findings support a possible future predictive role of NT-proSST concentrations.