..We demonstrate our technique on a study of brain tumors, for which our approach is capable of identifying subsets of tumors with different genomic profiles, and differentiates classes by survival much better than unsupervised methods...

..Novel tubular injury biomarkers may revolutionize the diagnosis of AKI; however, even if a novel tubular injury biomarker is 100% sensitive and 100% specific, it may appear inaccurate when using serum creatinine as the gold standard...

..For this data set, the existing unpenalized latent class methodology does not produce estimates. Additionally, we show that posterior classes obtained from this method are associated with survival for these patients...

..This paper investigates methodological limitations of the volume-outcome relationship. A brief overview of quality measurement is followed by a discussion of two important aspects of the relationship...

..In this article, we introduce several goodness-of-fit tests for the truncation distribution and investigate their performance in the presence of censored event times using simulation. We demonstrate the use of our tests on two data sets...

..The analysis of immunoglobulin heavy chain (IgH) gene rearrangements (AIGHR) was used as an adjunct to cytopathology and flow cytometry in systemic lymphoma. In IOL, the sensitivity and specificity of AIGHR are unknown...

..We propose adjusting for complex ascertainment schemes through a joint model for the outcomes of disease and ascertainment. This approach improves upon previous simplifying assumptions regarding the ascertainment process...

..The residual signals from this process were analyzed to identify disease-related copy number changes. We were able to identify distinct local changes at different chromosomes in patients with recurrent versus primary meningiomas...

Phase 2 study of bosutinib, a Src inhibitor, in adults with recurrent glioblastoma

..The optimal management of these patients has not been determined. We performed a multicenter, retrospective study of high-dose methotrexate in patients with relapsed central nervous system lymphoma...

..Properties of this model are explored in simulation studies, and the method is applied to a large family study of cancer conducted by the National Cancer Institute-sponsored Cancer Genetics Network (CGN)...

..Here we examine approaches for utilizing the entire study population, as well as the assumptions required for doing so. We illustrate that there are both costs and benefits to using the 25 selected patients...

Testing for dependence between failure time and visit compliance with interval-censored data

Rebecca A BetenskyDepartment of Biostatistics, Harvard School of Public Health, Boston, Massachusetts 02115, USABiometrics 58:58-63. 2002

..We illustrate the method with data from an AIDS study and we investigate the power of the test through a simulation study...

Family history of diabetes is a major determinant of endothelial function

..We evaluated whether endothelial dysfunction was present in nondiabetic persons with a family history (FH) of diabetes and assessed its relationship with insulin resistance and atherosclerosis risk factors...

A local likelihood proportional hazards model for interval censored data

..For estimation, we extend the modified EM algorithm suggested by Betensky, Lindsey, Ryan and Wand. We illustrate the method with data on times to deterioration of breast cosmeses and HIV-1 infection rates among haemophiliacs...

..Hippocampal metabolism (HM) studies comparing MCI and clinically normal (CN) elderly gave inconsistent results. As hippocampus is a key region in Alzheimer's disease, we hypothesized that HM is specifically decreased in high-amyloid MCI...

Thal Amyloid Stages Do Not Significantly Impact the Correlation Between Neuropathological Change and Cognition in the Alzheimer Disease Continuum

Alberto Serrano-PozoFrom the Department of Neurology of the University of Iowa Hospitals and Clinics, Iowa City, Iowa AS P Department of Biostatistics and Epidemiology of the University of Massachusetts, Amherst, Massachusetts JQ Massachusetts General Hospital Biostatistics Center, Boston, Massachusetts AM Department of Biostatistics, University of Washington, Seattle, Washington SEM Department of Pathology, School of Medicine of the University of Washington, Seattle, Washington TJM C S Kubik Laboratory for Neuropathology of the Massachusetts General Hospital MPF, Department of Neurology of the Massachusetts General Hospital, Boston, Massachusetts BTH Department of Biostatistics of the Harvard T H Chan School of Public Health, Boston, Massachusetts RAB and Massachusetts Alzheimer Disease Research Center, Charlestown, Massachusetts MPF, Rab, BTHJ Neuropathol Exp Neurol 75:516-26. 2016

..Multiple imputation offers a favorable alternative to complete case analysis and ad hoc substitution methods in the presence of randomly censored covariates within the framework of logistic regression...

..Presented is a series of 54 patients with MPNST seen at a single institution over a 10-year period. In this series, tumor diameter of <5 cm, gross total resection of the tumor, and younger age were favorable prognostic variables...

..A retrospective analysis of IVF data was performed to determine predictors of live birth rate in four common stimulation protocols. A combination of day 6 E2 levels, age, and day 3 FSH levels can be used to predict cycle outcome...

..We demonstrate the consistency and potentially improved efficiency of the estimators in simulation studies, and illustrate their use in application to studies of AIDS incubation and Parkinson's disease age of onset. ..

..This has important implications for assessing precursor frequency both in the fallopian tube and in other organs-such as prostate, pancreas and colon-where epithelial precursors are integral to carcinogenesis...

..Outcome predictions on the basis of microarray gene expression profiles have been the most accurate to date. We ask in a multivariate model whether clinical parameters enhance survival predictions of gene expression profiles...

..We develop analytic approximations for the power of the derived score tests for treatment differences in the hazard functions and evaluate them through simulations. We apply our results to AIDS Clinical Trials Group (ACTG) protocol 021...

..These results suggest that aCGH could offer an improved molecular diagnostic approach for gliomas because of its ability to detect clinically relevant molecular alterations in small FFPE specimens...