{4578} Primeמֵעָהme`ah{may-aw'}From an unused root probably meaning to be soft; used only in plural the intestines, or (collectively) the abdomen, figuratively sympathy; by implication a vest; by extension the stomach, the uterus (or of men, the seat of generation), the heart (figuratively).

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Genesis 25:23

Two nations are in thy womb  She was now big not only with two children, but two nations, which should not only in their manners greatly differ from each other, but in their interest contend with each other, and the issue of the contest should be that the elder should serve the younger, which was fulfilled in the subjection of the Edomites for many ages to the house of David.

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Two nations:

Genesis 17:16And I will bless her, and give thee a son also of her: yea, I will bless her, and she shall be [a mother] of nations; kings of people shall be of her.Genesis 24:60 And they blessed Rebekah, and said unto her, Thou [art] our sister, be thou [the mother] of thousands of millions, and let thy seed possess the gate of those which hate them.

two manner:

Genesis 25:27 And the boys grew: and Esau was a cunning hunter, a man of the field; and Jacob [was] a plain man, dwelling in tents.Genesis 32:6 And the messengers returned to Jacob, saying, We came to thy brother Esau, and also he cometh to meet thee, and four hundred men with him.Genesis 33:3 And he passed over before them, and bowed himself to the ground seven times, until he came near to his brother.Genesis 36:31 And these [are] the kings that reigned in the land of Edom, before there reigned any king over the children of Israel.Numbers 20:14 And Moses sent messengers from Kadesh unto the king of Edom, Thus saith thy brother Israel, Thou knowest all the travail that hath befallen us:

the elder:

Genesis 27:29Let people serve thee, and nations bow down to thee: be lord over thy brethren, and let thy mother's sons bow down to thee: cursed [be] every one that curseth thee, and blessed [be] he that blesseth thee.Genesis 27:40 And by thy sword shalt thou live, and shalt serve thy brother; and it shall come to pass when thou shalt have the dominion, that thou shalt break his yoke from off thy neck.2 Samuel 8:14 And he put garrisons in Edom; throughout all Edom put he garrisons, and all they of Edom became David's servants. And the LORD preserved David whithersoever he went.1 Kings 22:47 [There was] then no king in Edom: a deputy [was] king.1 Chronicles 18:13 And he put garrisons in Edom; and all the Edomites became David's servants. Thus the LORD preserved David whithersoever he went.2 Chronicles 25:11-12 And Amaziah strengthened himself, and led forth his people, and went to the valley of salt, and smote of the children of Seir ten thousand. ... And [other] ten thousand [left] alive did the children of Judah carry away captive, and brought them unto the top of the rock, and cast them down from the top of the rock, that they all were broken in pieces.Psalms 60:8-9Moab [is] my washpot; over Edom will I cast out my shoe: Philistia, triumph thou because of me. ... Who will bring me [into] the strong city? who will lead me into Edom?Psalms 83:5-15For they have consulted together with one consent: they are confederate against thee: ... So persecute them with thy tempest, and make them afraid with thy storm.Isaiah 34:1-17Come near, ye nations, to hear; and hearken, ye people: let the earth hear, and all that is therein; the world, and all things that come forth of it. ... And he hath cast the lot for them, and his hand hath divided it unto them by line: they shall possess it for ever, from generation to generation shall they dwell therein.Isaiah 63:1-6 Who [is] this that cometh from Edom, with dyed garments from Bozrah? this [that is] glorious in his apparel, travelling in the greatness of his strength? I that speak in righteousness, mighty to save. ... And I will tread down the people in mine anger, and make them drunk in my fury, and I will bring down their strength to the earth.Jeremiah 49:7-22 Concerning Edom, thus saith the LORD of hosts; [Is] wisdom no more in Teman? is counsel perished from the prudent? is their wisdom vanished? ... Behold, he shall come up and fly as the eagle, and spread his wings over Bozrah: and at that day shall the heart of the mighty men of Edom be as the heart of a woman in her pangs.Ezekiel 25:12-14 Thus saith the Lord GOD; Because that Edom hath dealt against the house of Judah by taking vengeance, and hath greatly offended, and revenged himself upon them; ... And I will lay my vengeance upon Edom by the hand of my people Israel: and they shall do in Edom according to mine anger and according to my fury; and they shall know my vengeance, saith the Lord GOD.Ezekiel 35:1-15 Moreover the word of the LORD came unto me, saying, ... As thou didst rejoice at the inheritance of the house of Israel, because it was desolate, so will I do unto thee: thou shalt be desolate, O mount Seir, and all Idumea, [even] all of it: and they shall know that I [am] the LORD.Amos 1:11-12 Thus saith the LORD; For three transgressions of Edom, and for four, I will not turn away [the punishment] thereof; because he did pursue his brother with the sword, and did cast off all pity, and his anger did tear perpetually, and he kept his wrath for ever: ... But I will send a fire upon Teman, which shall devour the palaces of Bozrah.Obadiah 1:1-16 The vision of Obadiah. Thus saith the Lord GOD concerning Edom; We have heard a rumour from the LORD, and an ambassador is sent among the heathen, Arise ye, and let us rise up against her in battle. ... For as ye have drunk upon my holy mountain, [so] shall all the heathen drink continually, yea, they shall drink, and they shall swallow down, and they shall be as though they had not been.Malachi 1:2-5I have loved you, saith the LORD. Yet ye say, Wherein hast thou loved us? [Was] not Esau Jacob's brother? saith the LORD: yet I loved Jacob, ... And your eyes shall see, and ye shall say, The LORD will be magnified from the border of Israel.Romans 9:10-13 And not only [this]; but when Rebecca also had conceived by one, [even] by our father Isaac; ... As it is written, Jacob have I loved, but Esau have I hated.