Sex hormones in men with coronary arteriosclerosis

Testosterone and estradiol levels were determined in 85 male patients aged between 23 and 52 years with: coronographically diagnosed coronary arteriosclerosis (20 with the instable and 37 with stable coronary disease), and in 28 healthy volunteers serving as a control group. Testosterone concentrations in the instable coronary disease (13.6 +/- 1.7 nM/l) were significantly lower than in the stable form of the disease (18.56 +/- 1.1 nM/l) and in healthy volunteers 20.9 +/- 1.0 nM/l, p less than 0.02 and p less than 0.001 respectively. Estradiol concentrations in male patients with instable coronary disease (228.3 +/- 22.8 pM/l) and with stable form of the disease (157.0 +/- 12.6 pM/l) were significantly higher than in healthy volunteers, p less than 0.02 and p less than 0.001 respectively. The obtained results indicate gonadal disorders in male patients with coronary arteriosclerosis.