The strongest in the Anime Realm....
--- In terms of the ability to destroy the universe:
Tenchi (He is literally god) and Washu, Tokimi, and Tsunami.
--- In terms of fighting ability with powers:
Vegitto (DBZ) - The guys can destroy worlds if he wanted to.
--- In terms of fighting without special abilities: (no fireballs, chakra, or weapons)
Great Teacher Onizuka!

Great teacher onizuka.....lol....I agree with the tenchi thing,

As 4 me: the ppl from vandread.....Hideki, Dita & the rest all form 2 make a super giganto robot that killed a whole fleet of ships!!!! & they can cover the planet in a barrier.....