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Ebertin utilized the research on astrologicalmidpoints of Hamburg School surveyor and astrologer Alfred Witte first published in 1928 in Witte's Regelwerk für Planetenbilder. Shortly after Witte's death in 1941, Ebertin used Witte's extensive research on astrological midpoints, and a 4th-harmonic "90° dial" developed by the Hamburg School of Astrology as the foundations of his School of Cosmobiology[citation needed]. Ebertin continued to promote astrological research, including medical applications of astrology while non-compliant Hamburg School astrologers were interned by the Third Reich, their books and publications banned.[citation needed]

Reinhold Ebertin's main reference text on Cosmobiology entitled The Combination of Stellar Influences, sometimes referred to as the 'CSI' or the 'COSI', was inspired by Alfred Witte's Rulebook of Planetary Pictures[1] . Ebertin's book was first published in 1940 and the most recent updates in the English translation were added in 1972. Ebertin's greatest and most truly original contribution was his research in the field of medical astrology and his addition of more psychological correlations.[2] Ebertin worked with the "Anatomical Correspondences of the Zodiac Degrees" as presented in the "Organuhr der anatomischen Entsprechungen" of Fritz Brandau.[3]

Due to Ebertin's work, he is sometimes considered the founder of modern Cosmobiology as the term is generally used today (working largely with the midpoint/dial paradigms of Witte), although the term 'Kosmobiologie' had been previously used by Dr Friedrich Feerhow and Swiss statistician Karl Krafft in a more general sense "to designate that branch of astrology working on scientific foundations and keyed to the natural sciences".[4]

^[Ebertin 1972, p.27 "(RPP) appeared to be revolutionary and provoked an unusual and mostly adverse criticism. The author has used that work extensively in his research..." followed by critical opinions later challenged by other students of Witte. Ebertin then continues on p.28 "Some of Witte's ideas may yet to prove useful, at some future time".]

^[(see earlier footnote where Ebertin acknowledged substantial reliance on Witte's RPP as a source: Ebertin 1972, pp.27-28. Ebertin then re-formatted and re-worded Witte's material -- much of the material added to the COSI/CSI which differed from Witte's RPP referred to specifics and details of medical astrology. Ebertin's most fully original written work manifest as "Astrological Healing" (see bibliography)]