More people are seeking alternatives to traditional mental health care and as a result, knowledge about the use of complementary therapies by people with mental illness is increasing – particularly for those experiencing anxiety and depression. A recent survey of women with depression revealed that there is a push for more “natural approaches” that match with the individual’s own values and beliefs. CAM (complementary and alternatives medicines) are also something people turn to when they are unhappy with their existing care – users are more likely to have received mental health and primary care treatment and to be dissatisfied with their overall healthcare when compared to non-users.

Numerous systematic reviews and research papers have been published on the effects of Western herbs, such as St John’s wort (Linde, Berner and Kriston Lin, 2008) in the treatment of depression, but Chinese herbs have received less attention. The aim of this paper was to assess the evidence on Chinese herbal medicine treatments for depression based on previous systematic reviews of trials in the Western literature.

The supplementary review located eight trials and positive results were reported almost universally. Limitations in methods and reporting, however, make it difficult to draw any firm conclusions.

Methods

St John’s Wort has been used as an alternative to conventional treatments for depression for many years in the UK

Randomised controlled trials (RCTs) of the treatment of depression with Chinese herbal medicine were located by searching all of the major Western bibliographic databases. The review located eight trials, three of which were not included in previous reviews. A variety of herbal formulae (combination of herbs) were investigated including Hypericum (St John’s wort) and Xia Yao San.

Inclusion criteria:

A diagnosis of clinical depression using conventional or traditional Chinese criteria

Interventions using Chinese herbal formulae or single Chinese herbs

Comparison included placebo, no treatment, or any active treatment

Improvement in depression (partial or complete alleviation of symptoms)

Exclusion criteria:

Chinese herbs combined with other complementary therapies

Participants with depression associated with other conditions

RCTs were evaluated using two rating scales: the Jadad criteria and the Downs and Black checklist. The effects of the herbal formulae were assessed in seven of the trials by comparing scores on the Hamilton Rating Scale for Depression (HAM-D) before and after treatment. A range of self-report measures and clinical assessment were also used.

Results

It was not possible to combine results to present any meaningful statistics as the herbal formulae and control treatments used, trial duration, and trial design all differed to such an extent. Where changes in depression scores were measured, clinically significant reductions were reported within groups with active treatment – either Chinese herbs or antidepressants and between-group comparisons suggested that Chinese herbs:

Were more effective than antidepressants – particularly Xiao Yao San and its modifications

Were comparable to antidepressants

Did not increase effectiveness but reduced adverse effects or relapse rates when used as an additional therapy with antidepressants

Were more effective than placebo

Limitations

The root of the Bupleurum plant is used to make Xiao Yao San

There were some major limitations in this review. In the majority of trials the methodological quality was poor and all of the trials were either at risk of bias or the overall risk of bias was unclear:

It is unclear if the patients selected were representative of the population, as the recruitment process was not reported

Few, if any, studies provided information on whether intervention and control groups were well matched at baseline, which statistical tests were used and whether participants took the herbal formulae as required

All studies were described as randomised, but several did not describe how randomisation had been carried out

Blinding was not always possible and this may have introduced some bias on self-report measures

There are also problems interpreting the results of these trials:

Despite herbal formulae having a similar name, they often contain different herbs

In trials comparing Chinese herbs against antidepressants, it is unclear whether the benefits are a true difference as there was no power calculation

Little or no detail was provided on dropout, making it difficult to determine the extent to which the Chinese herbs caused reductions in depression

The longest duration in these trials was 12 weeks, making it impossible to establish long-term efficacy

All research to date has been conducted in China so it is difficult to translate the results into a Western healthcare context

Conclusion

The effectiveness of Chinese herbal medicine in depression could not be fully substantiated based on current evidence

Positive results were reported in all of the trials identified and in all but one of the systematic reviews, but despite promising results, particularly for Xia Yao San and its modifications, the effectiveness of Chinese herbal medicine in depression could not be fully substantiated based on current evidence.

The extent to which the results of the study can be used to determine whether Chinese herbs caused reductions in depression (internal validity) or can be generalised to other groups (external validity) is severely limited due to a lack of detail in the research studies. Further well-designed trials would be of interest!

Jessamy is a Chartered Clinical Psychologist, she runs a private practice in London and prior to this worked for eight years in the NHS. She has a specialist interest in depression and anxiety disorders and is accredited in CBT. In addition to her clinical practice Jessamy is co-authoring a series of self-help books and contributes to various magazines. The books are due to be published in January 2014 by Quercus and will offer sound expert advice on the most common life-affecting issues that people typically experience, providing clear and simple ways to understand and overcome problems.

[…] Traditional Chinese Medicine uses herbs and acupuncture to address underlying imbalances in the body’s energetic organ meridian systems that can lead to depression. Source: The Case for Chinese Herbal Medicine in the Treatment of Depression […]

[…] Traditional Chinese Medicine uses herbs and acupuncture to address underlying imbalances in the body’s energetic organ meridian systems that can lead to depression. Source: The Case for Chinese Herbal Medicine in the Treatment of Depression […]