Source Normalized Impact per Paper (SNIP):2015: 0.535SNIP measures contextual citation impact by weighting citations based on the total number of citations in a subject field.

Impact per Publication (IPP): 0.512

Impact per Publication (IPP):2015: 0.512The Impact per Publication measures the average number of citations received in a particular year by papers published in the journal during the three preceding years.

SCImago Journal Rank (SJR): 0.28

SCImago Journal Rank (SJR):2016: 0.28SJR is a prestige metric based on the idea that not all citations are the same. SJR uses a similar algorithm as the Google page rank; it provides a quantitative and a qualitative measure of the journal’s impact.

A STUDY TO PREDICT ANTI-INFLAMMATORY ACTIVITY OF EUGENOL, MYRISTICIN, AND LIMONENE OF CINNAMOMUM SINTOC

Abstract

Objective: In this work we predicted anti-inflammatory activity of volatile oil of C. sintoc L.

Methods: Molecular docking was performed to predict the binding modes of eugenol, myristicin, and limonene chemical constituents of C. sintoc L. with COX enzymes, using Auto Dock 4.2. COX enzymes were obtained from Protein Data Bank (PDB); COX-1 (PDB code: 2AYL) and COX-2 (PDB code: 3PGH). Flurbiprofen and celecoxib were used as standards. Further assay was carried out on lipopolysaccharide (LPS)-induced fibroblast cells reacted with 800; 400; 200; 100; 50; 25 and 12.5 ul of C. sintoc L. bark essential oils. The absorbance of the product was measured using microplate reader at 450 nm. Acetosal was used as the standard drug.

Results: Eugenol and myristicin could be categorized as non-selective inhibitors of COX-2, while limonene is categorized as preferential COX-2 inhibitor. The essential oils of C. sintoc L. bark reduced PGE2 production on LPS-induced fibroblast cells. The inhibitory activity of C. sintoc L. was weaker than acetosal.

Conclusion: Bioactive compounds in essential oil of C. sintoc L. bark show inhibition on PGE2 production on LPS-induced human fibroblast cells, and could be categorized as COX inhibitors.