Purification Instruments, Columns and Modules

Strategic Partners

The Empiriko-Interchim partnership fully leverages Empiriko’s game-changing chemosynthetic liver technology (Biomimiks™) and Interchim’s innovative instrumentation and expertise in the field of chromatography. Interchim’s PuriFlash® and Prep HPLC columns are linked to a mass spectrometer which allows near real-time product separation and structure elucidation of purified compounds; these “smart devices” are ideally suited for taking full advantage of Empiriko’s Biomimiks™ technology. Together, our technology will accelerate the delineation of metabolism profiles, enable prediction and scale-up of products, and offer scientists a valuable tool for rapid separation and quantification of products.

Empiriko Overview

Empiriko is a Clinical Intelligence Technology (CIT) company that takes a unique, holistic approach to drug discovery, development and patient outcomes by combining scientific research and clinical observations with leading-edge technologies and advanced analytics. To achieve a higher level of predictive power, Empiriko has designed in vitro and ex vivo biomimetic systems – Biomimiks™ – that function as “chemosynthetic livers,” emulating the in vivo metabolism mediated by cytochromes P450 to generate and predict oxidative metabolic profiles of drugs. Our chemistry-based technology significantly reduces the time and cost associated with isolating and identifying drug metabolites using liver slices and bodily fluids extracted from animals.

Correlate isolated metabolites with those obtained from clinically isolated phenotypes.

Design an efficient method for the systematic preparation and identification of the entire spectrum of metabolites from a chosen drug.

Detect pharmaceutical products and their metabolites from serum, blood and urine.

Applying Biomimiks™ solutions, scientists can now reduce the attrition rate of NCEs by conducting metabolism studies on a range of compounds, generating quantitative measures of toxicity and reducing the cost of animal experimentation and necessity of animal sacrifice. In addition, clinicians can dynamically measure a patient’s response (drug-to-drug interactions, dosing levels and regimens) to a spectrum of drugs and incorporate the results into more effective diagnoses and patient treatment.