Target details

Target details

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Alternative Name

RB1

Background

RB1 is a negative regulator of the cell cycle and was the first tumor suppressor gene found. This protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1.Synonyms: Retinoblastoma-associated protein, pRb, Rb, pp110, p105-Rb, RB1