How we tick: U.S. 'body clock' scientists win Nobel medicine prize

Niklas Pollard and Ben Hirschler

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STOCKHOLM/LONDON (Reuters) - U.S. scientists Jeffrey Hall, Michael Rosbash and Michael Young won the 2017 Nobel prize for medicine on Monday for unraveling molecular mechanisms that control our internal body clocks.

These help explain how people experience jet lag when their internal circadian rhythms get out of sync, while also having wider implications for disorders ranging from insomnia to depression to heart disease.

Chronobiology, or the study of biological clocks, is now a growing field of research thanks to the pioneering work of the three scientists, who explained the role of specific genes in keeping fruit flies in step with light and darkness.

Today, scientists are exploring new treatments based on such circadian cycles, including establishing the best times to take medicines, and there is an increased focus on the importance of healthy sleeping patterns.

"This ability to prepare for the regular daily fluctuations is crucial for all life forms," Thomas Perlmann, secretary of the Karolinska Institute Nobel Committee, told reporters.

"This year's Nobel prize laureates have been studying this fundamental problem and solved the mystery of how an inner clock in our bodies can anticipate daily fluctuations between night and day to optimize our behavior and physiology."

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Rosbash said the news that the trio had won the Nobel prize, which is worth 9 million Swedish crowns ($1.1 million), was "a little overwhelming".

"It took my breath away, literally. I was woken up out of deep sleep and it was shocking," he told Reuters.

"It's great for basic science. It hasn't had a tremendous amount of practical impact yet, so it's really a very basic discovery ... It's good to have the attention on this kind of basic work."

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Hall, most recently of the University of Maine, collaborated with Rosbash while they both were at Brandeis University in Waltham, Massachusetts. They split the prize with Young of Rockefeller University in New York City.

Scientists were already pondering the concept of body clock genes in the 1960s and 1970s.

Then, in the mid-1980s, the three laureates used fruit flies to isolate a gene called period that controls the normal daily biological rhythm and showed how it encodes a protein called PER that accumulates in cells during the night and degrades during the day. Further research revealed the role of other genes in the complex system.

"We were hopeful what we did in the fly would pertain more widely," Young said in news briefing at Rockefeller University on Monday, but added that "it has unfolded in a way that just couldn't be imagined at the beginning."

Young said the trio could not have anticipated that the whole system could be revealed in their lifetimes, but new scientific tools helped accelerate the work.

Michael W. Young (C), a joint winner of the 2017 Nobel Prize in Physiology or Medicine, walks to a press conference at The Rockefeller University in New York, U.S., October 2, 2017.

Reuters/Shannon Stapleton

Brandeis University President Ronald Liebowitz (L) talks to 2017 Nobel Prize in Physiology or Medicine co-winner Michael Rosbash, a professor at Brandeis, at the university in Waltham, Massachusetts, U.S., October 2, 2017.

Reuters/Brian Snyder

The names of Jeffrey C. Hall, Michael Rosbash and Michael W. Young are displayed during a news conference to announce the winner of the Nobel Prize in Physiology or Medicine 2017, in Stockholm, Sweden October 2, 2017. TT News Agency/Jonas Ekstromer via

Reuters

Michael W. Young, a joint winner of the 2017 Nobel Prize in Physiology or Medicine, is pictured before the start of a press conference at The Rockefeller University in New York, U.S., October 2, 2017.

Reuters/Shannon Stapleton

Michael Rosbash, a Brandeis University professor, retrieves the morning newspaper after learning he is one of the 2017 Nobel Prize in Physiology or Medicine winners, at his home in Newton, Massachusetts, U.S., October 2, 2017.

Reuters/Brian Snyder

Michael W. Young, a joint winner of the 2017 Nobel Prize in Physiology or Medicine, speaks during a press conference at The Rockefeller University in New York, U.S., October 2, 2017.

Reuters/Shannon Stapleton

Michael Rosbash, a Brandeis University professor, proof-reads a press release after being named as a co-winner of the 2017 Nobel Prize in Physiology or Medicine at Brandeis University in Waltham, Massachusetts, U.S., October 2, 2017.

Reuters/Brian Snyder

U.S. scientist Michael Young who won the 2017 Nobel prize for medicine is seen in this undated Rockefeller University photo released on October 2, 2017. Courtesy Mario Morgado/The Rockefeller University/Handout via

Reuters

U.S. scientist Michael Rosbash who won the 2017 Nobel prize for medicine is seen in this undated Brandeis University photo released on October 2, 2017. Courtesy Brandeis University/Handout via

Reuters

Thomas Perlmann, Secretary of the Nobel Committee for Physiology or Medicine, announces the winners of the 2017 Nobel Prize in Physiology or Medicine during a press conference at the Nobel Forum in Stockholm, Sweden October 2, 2017. TT News Agency/Jonas Estromer via

Reuters

Michael Rosbash, a Brandeis University professor, stands in his home after learning he is one of the the 2017 Nobel Prize in Physiology or Medicine winners, in Newton, Massachusetts, U.S., October 2, 2017.

Reuters/Brian Snyder

"Just like puzzle pieces, the genes fell out and the way they work together provided this beautiful mechanism that we now appreciate."

Their discoveries help explain how plants, animals and humans adapt their biological rhythm to be in synch with the Earth's revolutions.

Scientists now understand that body clocks influence alertness, hunger, metabolism, fertility, mood and other physiological conditions. And researchers have begun to study the implications of erratic sleeping and working patterns or children who stay up late.

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"We are learning more and more what impact it has to not follow your clock," Nobel committee member Christer Hoog told Reuters. "If you constantly disobey your clock, what will happen? Medical research is going on with regards to that."

Medicine is the first of the Nobel Prizes awarded each year. The prizes for achievements in science, literature and peace were created in accordance with the will of dynamite inventor and businessman Alfred Nobel and have been awarded since 1901.

Nobel medicine laureates have included scientific greats such as Alexander Fleming, the discoverer of penicillin, and Karl Landsteiner, whose identification of separate blood types opened the way to carrying out safe transfusions.

The prize has not been without controversy, especially with the benefit of hindsight, such as the 1948 award for the discovery of DDT, a chemical that helped battle epidemics but was later banned due to its harmful environmental impact.