» Targeting malaria's 'sticky' proteins could put an end to the disease

Targeting malaria's 'sticky' proteins could put an end to the disease

Published: Monday, July 14, 2008, 16:09 [IST]

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Washington, July 10 : A team of Australian researchers have identified a key mechanism that enables malaria-infected red blood cells to stick to the walls of blood vessels and avoid being destroyed by the body''s immune system.

The discovery highlights an important potential new target for anti-malarial drugs.

Malaria is caused by the malaria parasite, which is injected into the bloodstream from the salivary glands of infected mosquitoes.

There are a number of different species of parasite, but the deadliest is the Plasmodium falciparum parasite.

The malaria parasite infects healthy red blood cells, where it reproduces, producing up to thirty-two new daughter parasites.

The parasite secretes a 'glue', known as PfEMP1, which travels to the surface of the infected red blood cells, leading to the formation of the knobs on the surface of the cells.

The cells become sticky and adhere to the walls of the blood vessels.

This prevents the cells being flushed through the spleen, where the parasites would be destroyed by the body''s immune system, but also restricts blood supply to vital organs.

Now, researchers, led by Professor Alan Cowman from the Walter and Eliza Hall Institute of Medical Research in Melbourne, Australia, have identified eight new proteins that transport the P. falciparum parasite''s 'glue' to the surface of the infected red blood cells.

They have shown that removing just one of these proteins prevents the infected red blood cells from sticking to the walls of the blood vessels.