Longevity In The Genes, Not In Lifestyle

Longevity could be in the genes, not necessarily in one's lifestyle, researchers have concluded. As a wag put it, Winston Churchill, who drank and smoked, lived right up to the age of 90, but Swami Vivekananda, who led an ascetic life, could not touch even 40!

Longevity In The Genes, Not In Lifestyle

The findings of the scientists with the Albert Einstein College of Medicine, Yeshiva University, New York seem to indicate that "nature" (in the form of protective longevity genes) might be more important than "nurture" (lifestyle behaviors) when it comes to living an exceptionally long life.

Dr. Nir Barzilai, director of the Institute for Aging Research and his Einstein colleagues interviewed 477 Ashkenazi Jews who were living independently and were 95 and older (95-112, 75 percent of them women). They were enrolled in Einstein's Longevity Genes Project, an ongoing study that seeks to understand why centenarians live as long as they do. (Descended from a small founder group, Ashkenazi Jews are more genetically uniform than other populations, making it easier to spot gene differences that are present.)

The elderly participants were asked about their lifestyles at age 70, considered representative of the lifestyle they'd followed for most of their adult lives. They answered questions about their weight and height so that their body mass index (BMI) could be calculated. They also provided information about their alcohol consumption, smoking habits, physical activity, and whether they ate a low-calorie, low-fat or low-salt diet.

To compare these long-lived individuals with the general population, the researchers used data from 3,164 people who had been born around the same time as the centenarians and were examined between 1971 and 1975 while participating in the National Health and Nutrition Examination Survey (NHANES I).

Overall, people with exceptional longevity did not have healthier habits than the comparison group in terms of BMI, smoking, physical activity, or diet. For example, 27 percent of the elderly women and an equal percentage of women in the general population attempted to eat a low-calorie diet. Among long-living men, 24 percent consumed alcohol daily, compared with 22 percent of the general population. And only 43 percent of male centenarians reported engaging in regular exercise of moderate intensity, compared with 57 percent of men in the comparison group.

"In previous studies of our centenarians, we've identified gene variants that exert particular physiology effects, such as causing significantly elevated levels of HDL or 'good' cholesterol," said Dr. Barzilai, who is also professor of medicine and of genetics at Einstein. "This study suggests that centenarians may possess additional longevity genes that help to buffer them against the harmful effects of an unhealthy lifestyle."

The research did find, however, that overweight centenarians tended to have lower rates of obesity than the control group. Although male and female centenarians were just as likely to be overweight as their counterparts in the general population, the centenarians were significantly less likely to become obese: only 4.5 percent of male centenarians were obese vs. 12.1 percent of controls; and for women, 9.6 percent of centenarians were obese versus 16.2 percent of controls. Both of these differences are statistically significant.

While longevity genes may protect centenarians from bad habits, healthy lifestyle choices remain critical for the vast majority of the population. The U.S. Census Bureau estimates there were nearly 425,000 people aged 95 and older living in the U.S. in 2010 − a fraction (.01) of the 40 million U.S. adults 65 and over.

"Although this study demonstrates that centenarians can be obese, smoke and avoid exercise, those lifestyle habits are not good choices for most of us who do not have a family history of longevity," said Dr. Barzilai. "We should watch our weight, avoid smoking and be sure to exercise, since these activities have been shown to have great health benefits for the general population, including a longer lifespan."

Researchers also asked study participants why they believed they had lived so long. Most did not attribute their advanced age to lifestyle factors. One-third reported a history of family longevity, while 20 percent believed that physical activity also played a role in their lifespan. Other factors included positive attitude (19 percent), busy or active life (12 percent), less smoking and drinking (15 percent), good luck (8 percent), and religion or spirituality (6 percent).

The findings have been published in the online edition of Journal of the American Geriatrics Society.

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