TNF-alpha IHC Antibody

Ready To Use

Catalog
Number

Size

Price

Availability

IW-PA1079

9 ml

$258

Yes

Description

TNFα (Tumor Necrosis Factor alpha) gene encodes a
multifunctional proinflammatory cytokine that belongs to the
tumor necrosis factor (TNF) superfamily. This cytokine is
mainly secreted by macrophages. It can bind to, and thus
functions through its receptors TNFRSF1A/TNFR1 and
TNFRSF1B/TNFBR. This cytokine is involved in the regulation
of a wide spectrum of biological processes including cell
proliferation, differentiation, apoptosis, lipid metabolism,
and coagulation. This cytokine has been implicated in a
variety of diseases, including autoimmune diseases, insulin
resistance, and cancer. Knockout studies in mice also
suggested the neuroprotective function of this cytokine.

Catalog Number

IW-PA1079

Quantity

9 ml

Host

Rabbit

Clone

Polyclonal

Isotype

IgG

Immunogen

A synthetic peptide corresponding to a sequence at the
C-terminal of human TNFalpha, different from the related
mouse sequence by five amino acids, and rat sequence by
seven amino acids.

Purity

Immunogen affinity purified

Conjugate

Unconjugated

Species Reactivity

Human, mouse, rat.
Not tested in other species.

Positive Control

Human mammary cancer

, colon cancer, brain

Cellular Localization

Cytoplasmic

Form

Ready to use solution. No further dilution needed. Serum
blocking step should be omitted.