Comment

I am VERY concerned about the global approval of this model in both the peer review and the user comment. This model was presented by a plenary speaker at the Experimental Biology 2001 meeting as an example of a representation that does not always fit the data about how muscle works. As with most models, this one has serious limitations and it should not be taught as fact. An alternative source of information comes from muscle physiologists. Refer to the MERLOT site called "Video of myosin v movement along actin" and the research group that presents an alternative model at the bottom of the page at http://www.mrc-lmb.cam.ac.uk/myosin/motility/XBcycle.html Perhaps students should be asked to compare and contrast the models to decide which model best matches what we know about actin-myosin interactions ( a critical thinking approach that would leave student with a more realistic view to the limits of our understanding).

Technical Remarks:

The animations at the links listed above are stacks of gif images.

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