Browse Databases and Tools

About this Resource

The Cochrane Database of Systematic Reviews is considered the gold standard for
evidence-based medicine. Essential Evidence Plus includes the latest and most
up-to-date summaries of systematic reviews from the Cochrane Library, which are
the most rigorous and reliable evaluations of medical therapies available. You’ll
find summarized evaluations of the world’s best literature on the effectiveness of
therapy for 3,300+ clinical problems.

Pharmacotherapy for sleep bruxismCochrane Systematic Reviews, 13-Oct-2014Sleep bruxism is an oral activity characterized by involuntary teeth grinding or clenching during sleep. Several forms of treatment have been proposed for this disorder, including behavioural, dental and pharmacological strategies.

Pharmacotherapy for social anxiety disorder (SAnD)Cochrane Systematic Reviews, 11-Oct-2017Recognition is growing that social anxiety disorder (SAnD) is a chronic and disabling disorder, and data from early trials demonstrate that medication may be effective in its treatment. This systematic review is an update of an earlier review of pharmacot

Pharmacotherapy for trichotillomaniaCochrane Systematic Reviews, 7-Nov-2013Trichotillomania (TTM) (hair-pulling disorder) is a prevalent and disabling disorder characterised by recurrent hair-pulling. The effect of medication on trichotillomania has not been systematically evaluated.

Phenytoin for neuropathic pain and fibromyalgia in adultsCochrane Systematic Reviews, 11-Oct-2017Antiepileptic drugs have been used in pain management since the 1960s; some have shown efficacy in treating different neuropathic pain conditions. Phenytoin is an established antiepileptic drug that has been used occasionally to treat intractable trigemin

Phlebotonics for haemorrhoidsCochrane Systematic Reviews, 9-Jul-2012Haemorrhoids are variceal dilatations of the anal and perianal venous plexus and often develop secondary to the persistently elevated venous pressure within the haemorrhoidal plexus (Kumar 2005). Phlebotonics are a heterogenous class of drugs consisting o

Phlebotonics for venous insufficiencyCochrane Systematic Reviews, 1-Apr-2016Chronic venous insufficiency (CVI) is a common condition caused by valvular dysfunction with or without associated obstruction, usually in the lower limbs. It might result in considerable discomfort with symptoms such as pain, itchiness and tiredness in t

Phonics training for English-speaking poor readersCochrane Systematic Reviews, 14-Nov-2012Around 5% of English speakers have a significant problem with learning to read words. Poor word readers are often trained to use letter-sound rules to improve their reading skills. This training is commonly called phonics. Well over 100 studies have admin

Phosphodiesterase 4 inhibitors for chronic obstructive pulmonary diseaseCochrane Systematic Reviews, 19-Sep-2017Chronic obstructive pulmonary disease (COPD) is associated with cough, sputum production or dyspnoea and a reduction in lung function, quality of life and life expectancy. Apart from smoking cessation, there are no other treatments that slow lung function

Phosphodiesterase 5 inhibitors for pulmonary hypertensionCochrane Systematic Reviews, 29-Mar-2009Pulmonary Hypertension (PH) can be either of unknown aetiology (primary pulmonary hypertension (PPH)) or due to a known underlying cause (secondary pulmonary hypertension (SPH). Pulmonary arteriolar vasoconstriction is considered to be an important charac

Phosphodiesterase III inhibitors for heart failureCochrane Systematic Reviews, 29-Nov-2012In the treatment of chronic heart failure, vasodilating agents, ACE inhibitors and beta-blockers have shown an increase of life expectancy. Another strategy is to increase the inotropic state of the myocardium : phosphodiesterase inhibitors (PDIs) act by

Photodynamic therapy for neovascular age-related macular degenerationCochrane Systematic Reviews, 12-Aug-2009In neovascular age-related macular degeneration (AMD) new vessels grow under the retina distorting vision and leading to scarring. This is exacerbated if the blood vessels leak. Photodynamic therapy (PDT) has been investigated as a way to treat the neovas