The five-time finalist and two-time champion has his nose out of joint after being relegated to third in the seedings behind Federer. A 19th grand slam title to edge to within one of the great Swiss would be sufficient pay back.

The ageless marvel is bidding to become the oldest grand slam champion in history and it would be dangerous to back against the near-38-year-old after he warmed up with a 10th triumph in Halle.

DOMINIC THIEM (AUT)

Age: 25

Ranking: 4

Plays: right-handed (two-handed backhand)

Career prize money: $US18,140,486 ($A26.36 million)

Career titles: 13

Grand slam titles: 0

Wimbledon win-loss record: 5-5

Best Wimbledon result: fourth round 2017

Runner-up to Nadal in Paris the past two years, the Austrian has yet to make the transition from clay to grass and any run beyond the fourth round would be considered a success.

ALEXANDER ZVEREV (GER)

Age: 22

Ranking: 5

Plays: right-handed (two-handed backhand)

Career prize money: $US17,273,296 ($A24.83 million)

Career titles: 11

Grand slam titles: 0

Wimbledon win-loss record: 8-4

Best Wimbledon result: fourth round 2017

German's big white hope continues to disappoint at the majors, notching only two quarter-final appearances in 16 slams - and both coming on clay at Roland Garros.

STEFANOS TSITSIPAS (GRE)

Age: 20

Ranking: 6

Plays: right-handed (two-handed backhand)

Career prize money: $US5,883,282 ($A8.46 million)

Career titles: 3

Grand slam titles: 0

Wimbledon win-loss record: 3-2

Best Wimbledon result: fourth round 2018

The Greek sensation looks the real deal and certainly the most likely of the next-gen stars to break the big three's domination of the slams.

BEST OUTSIDER

KEVIN ANDERSON (RSA)

Age: 33

Ranking: 8

Plays: right-handed (two-handed backhand)

Career prize money: $US16,140,150 ($A23.20 million)

Career titles: 6

Grand slam titles: 0

Wimbledon win-loss record: 18-10

Best Wimbledon result: runner-up 2018

Last year's finalist has been elevated to fourth seed but has endured an injury-marred 2019 campaign and won just one match on grass this summer.

BEST AUSTRALIAN HOPES

ALEX DE MINAUR

Age: 20

Ranking: 26

Plays: right-handed (two-handed backhand)

Career prize money: $US1,989,106 ($A2.86 million)

Career titles: 1

Grand slam titles: 0

Wimbledon win-loss record: 2-1

Best Wimbledon result: third round 2018

Seeded at the All England Club for the first time after starting the year on fire with a maiden ATP title in Sydney, but struggling for the first time with injuries.

NICK KYRGIOS

Age: 24

Ranking: 39

Plays: right-handed (two-handed backhand)

Career prize money: $US7,289,850 ($A10.48 million)

Career titles: 5

Grand slam titles: 0

Wimbledon win-loss record: 12-5

Best Wimbledon result: quarter-finalist 2014

Anyone's guess how the temperamental talent will fare. Unseeded at his favourite event for the first time since bursting onto the scene with a stunning win over Nadal on his Wimbledon debut five years ago.