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Program Description

Ixolaris, a novel TFPI molecule

Research in the Vector Biology Section explores the biochemical and pharmacological diversity found in the salivary glands of blood feeding insects and ticks. Molecular, biochemical, and pharmacological approaches are used in our research. Recently, we have used vector salivary gland transcriptome analysis to discover new and interesting compounds and for that reason have developed tools for bioinformatic analysis.

In each of the major areas of research, we seek discoveries that improve our basic knowledge of the evolution of the blood feeding behavior, at the same time generating novel compounds that can be of pharmacological use or developed as vaccine targets. Inquiries about predoctoral and postdoctoral fellowships as well as Ph.D. studentships in the National Institutes of Health Graduate Partnership Program are welcome.

The figure shows the structure of Ixolaris, an anti-clotting protein derived from the tick Ixodes scapularis (also pictured). This protein has anti-clotting and anti-metastatic properties.

Biography

Dr. Ribeiro received his M.D. from the State University of Rio de Janeiro and a Ph.D. from the Biophysics Institute of the Federal University of Rio de Janeiro. He was an assistant and associate professor at the Harvard School of Public Health and professor at the department of entomology in the University of Arizona before joining NIAID in 1996. His work focuses on the role of vector saliva in blood feeding by arthropods, where a great diversity of pharmacologically active compounds and new targets for vaccination against vector-borne diseases have been uncovered. Dr. Ribeiro has served for many years in the Tropical Diseases Research Program of the World Health Organization and as editor and reviewer for several journals.

Patents

Valenzuela JG, Ribeiro JM, Barral A, Netto M, Brodskyn C, Gomes R, inventors; The United States of America as represented by the Secretary of the Department of Health and Human Services, assignee. Lutzomyia longipalpis polypeptides and methods of use. United States patent US 8,628,780. 14 Jan 2014.

Fischer LB, Valenzuela JG, Ribeiro JM, Kamhawi S, inventors; Merial Limited, The United States as represented by the Secretary of the Department of Health and Human Services, assignees. Leishmania vaccine using sand fly salivary immunogen. United States patent US 8,603,808. 10 Dec 2013.

Calvo E, Marinotti O, Ribeiro JM, Francischetti IM, inventors; The United States of America, as represented by the Secretary, Department of Health and Human Services, Regents of the University of California, assignees. Aegyptin and uses thereof. United States patent US 8,383,589. 26 Feb 2013.

Valenzuela JG, Ribeiro JMC, Barral A, Netto M, Brodskyn C, Gomes R, inventors; The United States of America as represented by the Secretary of the Department of Health and Human Services, Cruz, assignees. Lutzomyia longipalpis polypeptides and methods of use. United States patent US 7,485,306. 3 Feb 2009.