Molecular and Cell Biology (MCELLBI)

Courses

MCELLBI 15Current Topics in the Biological Sciences2 Units

Terms offered: Spring 2018, Spring 2017, Spring 2016
Students in this course will critically examine modern methods of biological investigations and their social implications. Relevant literature will be used to present basic biological concepts that address the cultural, technological and health aspects of current topics in the biological sciences. Designing and evaluating scientific questions will be stressed.Current Topics in the Biological Sciences: Read More [+]

Rules & Requirements

Prerequisites: Suitable for freshmen who plan to major in a biological science

Repeat rules: Course may be repeated for credit as topic varies. Course may be repeated for credit when topic changes.

MCELLBI C31Big Ideas in Cell Biology3 Units

Terms offered: Spring 2014, Spring 2012
An introduction for students who do not intend to major in biology but who wish to satisfy their breadth requirement in Biological Sciences. Some major concepts of modern biology, ranging from the role of DNA and the way cells communicate, to interactions of cells and creatures with their environment, will be discussed without jargon and with attention to their relevance in contemporary life and culture.Big Ideas in Cell Biology: Read More [+]

MCELLBI 38Stem Cell Biology, Ethics and Societal Impact3 Units

Terms offered: Spring 2018
Innovations in bioengineering and use of stem cells will significantly impact our ability to combat human disease, genetic disorders and physiological dysfunction. An understanding of human stem cell biology will be critical to make informed decisions on our health and public policy.Stem Cell Biology, Ethics and Societal Impact: Read More [+]

MCELLBI C44Biology for Voters3 Units

Terms offered: Spring 2017, Spring 2015, Spring 2014
This is a Discovery Course for non-Biology majors designed to introduce lower-division college students to biology through the lens of the contemporary problems facing people, the planet and the species of the planet. Modern genetic contributions will be presented on such issues as genetic engineering of plants and animals, the emergence of new pathogens, the role of genetic variation among individuals, and the extent to which DNA is and isn’t destiny. Each week will close with the presentation and discussion of a defining biological challenge facing the world.Biology for Voters: Read More [+]

Objectives & Outcomes

Student Learning Outcomes: The learning objectives will be, at one end, to understand what an experiment is, how is it controlled and what does one need to know about an experiment to be able to rely upon any conclusion. That is the fundamental issue in all science, and is frequently overlooked in many media accounts of science. A second objective is to learn enough of the language of biology to be able to ask the kind of informed questions that we would want all elected representatives to pay attention to. A third objective is for students to cultivate confidence that through non-specialized information sources they can become informed consumers of contemporary scientific thought, and to develop those habits of intellect to think about evidence in a scientific manner. A fourth objective is for students to enjoy the abundance of high quality books, articles and multimedia that will enable a lifetime of discovery outside the structure of a college course.

MCELLBI 50The Immune System and Disease4 Units

Terms offered: Spring 2018, Spring 2017, Spring 2016
Course will discuss how the immune system resolves, prevents, or causes disease. A general overview of the immune system will be covered in the first five weeks followed by five weeks discussing infectious diseases including anthrax, mad cow, herpes, malaria, tuberculosis, and HIV. In addition, other lectures will focus on current immunology topics including vaccines, autoimmunity, allergy, transplantation, and cancer.The Immune System and Disease: Read More [+]

Rules & Requirements

Prerequisites: High school chemistry or Chemistry 1A and high school biology or Biology 1A. Biology 1AL is not required

Credit Restrictions: Students will receive no credit for Molecular and Cell Biology 50 after completing Molecular and Cell Biology 102, C100A/Chemistry C130, or Chemistry 135. <BR/>

MCELLBI 55Plagues and Pandemics3 Units

Terms offered: Fall 2017, Fall 2016, Fall 2015
Discussion of how infectious agents cause disease and impact society at large. We will examine historical and current examples of plagues and pandemics and consider the question of what we should do to ameliorate the impact of infectious disease in the future. The course is intended for non-majors and will begin by briefly providing necessary background in microbiology and immunology. The primary focus in each subsequent week, however, will be on discussing a particular infectious disease. The course will be broad in scope covering biological, historical, ethical and social implications of each disease.Plagues and Pandemics: Read More [+]

MCELLBI C61Brain, Mind, and Behavior3 Units

Terms offered: Spring 2018, Spring 2017, Spring 2016
Introduction to human brain mechanisms of sensation, movement, perception, thinking, learning, memory, and emotion in terms of anatomy, physiology, and chemistry of the nervous system in health and disease. Intended for students in the humanities and social sciences and others not majoring in the biological sciences.Brain, Mind, and Behavior: Read More [+]

MCELLBI W61Brain, Mind, and Behavior3 Units

Terms offered: Summer 2017 First 6 Week Session, Summer 2016 10 Week Session, Summer 2015 First 6 Week Session
This course deals with the structure and function of the human nervous system, with an emphasis on how brain physiology and chemistry are related to human behavior. This is a comprehensive introduction to the exciting field of contemporary neuroscience for students of all backgrounds and interests, including those from the humanities and social sciences, as well as physical and biological sciences. The Final Examination will be administered in a proctored setting. See Schedule of Classes for meeting information. This course is web-based.Brain, Mind, and Behavior: Read More [+]

MCELLBI C62Drugs and the Brain3 Units

Terms offered: Fall 2017, Fall 2015, Fall 2014
The history, chemical nature, botanical origins, and effects on the human brain and behavior of drugs such as stimulants, depressants, psychedelics, analgesics, antidepressants, antipsychotics, steroids, and other psychoactive substances of both natural and synthetic origin. The necessary biological, chemical, and psychological background material for understanding the content of this course will be contained within the course itself.Drugs and the Brain: Read More [+]

MCELLBI 63Introduction to Functional Neuroanatomy3 Units

Terms offered: Summer 2017 Second 6 Week Session, Summer 2016 10 Week Session, Summer 2016 Second 6 Week Session
This course emphasizes beginning anatomy of the brain and spinal cord to individuals interested in understanding the dynamics of motor and sensory functions in the human body. Students in the Departments of Education, Psychology, and Integrative Biology, as well as students interested in medicine and the life sciences, are especially encouraged to attend.Introduction to Functional Neuroanatomy: Read More [+]

MCELLBI 84Sophomore Seminar0.0 Units

Terms offered: Prior to 2007
Sophomore seminars are small interactive courses offered by faculty members in departments all across the campus. Sophomore seminars offer opportunity for close, regular intellectual contact between faculty members and students in the crucial second year. The topics vary from department to department and semester to semester. Enrollment limited to 15 sophomores.Sophomore Seminar: Read More [+]

Rules & Requirements

Prerequisites: At discretion of instructor

Repeat rules: Course may be repeated for credit as topic varies. Course may be repeated for credit when topic changes.

MCELLBI 84BSophomore Seminar1 or 2 Units

Terms offered: Fall 2013, Spring 2013, Fall 2012
Sophomore seminars are small interactive courses offered by faculty members in departments all across the campus. Sophomore seminars offer opportunity for close, regular intellectual contact between faculty members and students in the crucial second year. The topics vary from department to department and semester to semester. Enrollment limited to 15 sophomores.Sophomore Seminar: Read More [+]

MCELLBI 88Immunotherapy of Cancer: Success and Failures2 Units

Terms offered: Spring 2018, Spring 2017
We will work with a variety of datasets that describe a molecular view of cells and how they divide. We will learn about the processes that cause cells to become specialized (differentiate) and to give rise to cancer (transform). We will analyze data on genetic mutations in cancer that distinguish tumor cells from normal cells. We will learn how mutations are detected by the immune system and the basis of cancer immunotherapy. Finally we will analyze data on clinical trials of cancer immunotherapy to define the correlates of success in curing the disease. The students are expected to gain an understanding of data that reveals the basics of cell physiology and cancer, how immunotherapies of cancer work and their current limitations.Immunotherapy of Cancer: Success and Failures: Read More [+]

Terms offered: Fall 2017, Spring 2017, Fall 2016
The Berkeley Seminar Program has been designed to provide new students with the opportunity to explore an intellectual topic with a faculty member in a small-seminar setting. Berkeley Seminars are offered in all campus departments, and topics vary from department to department and semester to semester.Freshman Seminars: Biochemistry and Molecular Biology: Read More [+]

Rules & Requirements

Prerequisites: Open to freshmen only

Hours & Format

Fall and/or spring: 15 weeks - 1 hour of seminar per week

Additional Details

Subject/Course Level: Molecular and Cell Biology/Undergraduate

Grading/Final exam status: The grading option will be decided by the instructor when the class is offered. Final exam required.

MCELLBI 90BFreshman Seminars: Cell and Developmental Biology1 Unit

Terms offered: Spring 2018, Fall 2017, Fall 2016
The Berkeley Seminar Program has been designed to provide new students with the opportunity to explore an intellectual topic with a faculty member in a small-seminar setting. Berkeley Seminars are offered in all campus departments, and topics vary from department to department and semester to semester.Freshman Seminars: Cell and Developmental Biology: Read More [+]

Rules & Requirements

Prerequisites: Open to freshmen only

Hours & Format

Fall and/or spring: 15 weeks - 1 hour of seminar per week

Additional Details

Subject/Course Level: Molecular and Cell Biology/Undergraduate

Grading/Final exam status: The grading option will be decided by the instructor when the class is offered. Final exam required.

MCELLBI 90CFreshman Seminars: Genetics and Development1 Unit

Terms offered: Fall 2016, Fall 2010, Spring 2007
The Berkeley Seminar Program has been designed to provide new students with the opportunity to explore an intellectual topic with a faculty member in a small-seminar setting. Berkeley Seminars are offered in all campus departments, and topics vary from department to department and semester to semester.Freshman Seminars: Genetics and Development: Read More [+]

Rules & Requirements

Prerequisites: Open to freshmen only

Hours & Format

Fall and/or spring: 15 weeks - 1 hour of seminar per week

Additional Details

Subject/Course Level: Molecular and Cell Biology/Undergraduate

Grading/Final exam status: The grading option will be decided by the instructor when the class is offered. Final exam required.

MCELLBI 90DFreshman Seminars: Immunology1 Unit

Terms offered: Fall 2017, Fall 2016, Spring 2014
The Berkeley Seminar Program has been designed to provide new students with the opportunity to explore an intellectual topic with a faculty member in a small-seminar setting. Berkeley Seminars are offered in all campus departments, and topics vary from department to department and semester to semester.Freshman Seminars: Immunology: Read More [+]

Rules & Requirements

Prerequisites: Open to freshmen only

Hours & Format

Fall and/or spring: 15 weeks - 1 hour of seminar per week

Additional Details

Subject/Course Level: Molecular and Cell Biology/Undergraduate

Grading/Final exam status: The grading option will be decided by the instructor when the class is offered. Final exam required.

MCELLBI 90EFreshman Seminars: Neurobiology1 Unit

Terms offered: Spring 2018, Fall 2017, Spring 2017
The Berkeley Seminar Program has been designed to provide new students with the opportunity to explore an intellectual topic with a faculty member in a small-seminar setting. Berkeley Seminars are offered in all campus departments, and topics vary from department to department and semester to semester.Freshman Seminars: Neurobiology: Read More [+]

Rules & Requirements

Prerequisites: Open to freshmen only

Hours & Format

Fall and/or spring: 15 weeks - 1 hour of seminar per week

Additional Details

Subject/Course Level: Molecular and Cell Biology/Undergraduate

Grading/Final exam status: The grading option will be decided by the instructor when the class is offered. Final exam required.

MCELLBI 91DImmunology2 - 4 Units

Terms offered: Prior to 2007
Freshman and sophomore seminars offer lower division students the opportunity to explore an intellectual topic with a faculty member and a group of peers in a small-seminar setting. These seminars are offered in all campus departments; topics vary from department to department and from semester to semester.Immunology: Read More [+]

Rules & Requirements

Prerequisites: Open to freshmen and sophomores only

Hours & Format

Fall and/or spring: 15 weeks - 2-4 hours of seminar per week

Additional Details

Subject/Course Level: Molecular and Cell Biology/Undergraduate

Grading/Final exam status: The grading option will be decided by the instructor when the class is offered. Final exam required.

MCELLBI C96Studying the Biological Sciences1 Unit

Terms offered: Fall 2017, Fall 2016, Fall 2015
Freshmen will be introduced to the "culture" of the biological sciences, along with an in-depth orientation to the academic life and the culture of the university as they relate to majoring in biology. Students will learn concepts, skills, and information that they can use in their major course, and as future science professionals. Restricted to freshmen in the biology scholars program.Studying the Biological Sciences: Read More [+]

MCELLBI 100BBiochemistry: Pathways, Mechanisms, and Regulation4 Units

Terms offered: Spring 2018, Spring 2017, Spring 2016
We survey cellular metabolic pathways, with focus on the underlying chemistry, bioenergetics, and mechanisms. We discuss signaling in the context of a physical chemical understanding of diffusion, transport and molecular interactions. We will highlight the intertwining of signaling and dysregulation with metabolic disorders and cancer, and the production of renewable chemicals such as biofuels. The course is designed for majors in the biochemistry and molecular biology, genetics and development, or immunology emphases.Biochemistry: Pathways, Mechanisms, and Regulation: Read More [+]

MCELLBI 102Survey of the Principles of Biochemistry and Molecular Biology4 Units

Terms offered: Spring 2018, Fall 2017, Summer 2017 8 Week Session
A comprehensive survey of the fundamentals of biological chemistry, including the properties of intermediary metabolites, the structure and function of biological macromolecules, the logic of metabolic pathways (both degradative and biosynthetic) and the molecular basis of genetics and gene expression.Survey of the Principles of Biochemistry and Molecular Biology: Read More [+]

MCELLBI C103Bacterial Pathogenesis3 Units

Terms offered: Spring 2018, Spring 2017, Spring 2016
This course for upper division and graduate students will explore the molecular and cellular basis of microbial pathogenesis. The course will focus on model microbial systems which illustrate mechanisms of pathogenesis. Most of the emphasis will be on bacterial pathogens of mammals, but there will be some discussion of viral and protozoan pathogens. There will be an emphasis on experimental approaches. The course will also include some aspects of bacterial genetics and physiology, immune response to infection, and the cell biology of host-parasite interactions.Bacterial Pathogenesis: Read More [+]

MCELLBI 104Genetics, Genomics, and Cell Biology4 Units

Terms offered: Spring 2018, Fall 2017, Spring 2017
This course will introduce students to key concepts in genetic analysis, eukaryotic cell biology, and state-of-the-art approaches in genomic medicine. Lectures will highlight basic knowledge of cellular processes with the basis for human diseases, particularly cancer. Prerequisite courses will have introduced students to the concepts of cells, the central dogma of molecular biology, and gene regulation. Emphasis in this course will be on eukaryotic cell processes, including cellular organization, dynamics, and signaling.Genetics, Genomics, and Cell Biology: Read More [+]

MCELLBI C112General Microbiology4 Units

Terms offered: Fall 2017, Summer 2017 10 Week Session, Fall 2016
This course will explore the molecular bases for physiological and biochemical diversity among members of the two major domains, Bacteria and Archaea. The ecological significance and evolutionary origins of this diversity will be discussed. Molecular, genetic, and structure-function analyses of microbial cell cycles, adaptive responses, metabolic capability, and macromolecular syntheses will be emphasized.General Microbiology: Read More [+]

MCELLBI C112LGeneral Microbiology Laboratory2 Units

Terms offered: Spring 2018, Fall 2017, Summer 2017 10 Week Session
Experimental techniques of microbiology designed to accompany the lecture in C112 and C148. The primary emphasis in the laboratory will be on the cultivation and physiological and genetic characterization of bacteria. Laboratory exercises will include the observation, enrichment, and isolation of bacteria from selected environments.General Microbiology Laboratory: Read More [+]

MCELLBI C114Introduction to Comparative Virology4 Units

Terms offered: Spring 2018, Spring 2017, Spring 2016
This course will provide a comparative overview of virus life cycles and strategies viruses use to infect and replicate in hosts. We will discuss virus structure and classification and the molecular basis of viral reproduction, evolution, assembly, and virus-host interactions. Common features used during virus replication and host cellular responses to infection will be covered. Topics also included are common and emerging virus diseases, their control, and factors affecting their spread.Introduction to Comparative Virology: Read More [+]

Rules & Requirements

Prerequisites: Introductory chemistry (Chemistry 1A or 3A-3B or equivalent) and introductory biology (Biology 1A, 1AL, and 1B or equivalent) and general biochemistry (Molecular and Cell Biology C100A or equivalent--preferably completed but may be taken concurrently)

MCELLBI C116Microbial Diversity3 Units

Terms offered: Fall 2017, Fall 2016, Fall 2015
This course for upper-division and graduate students will broadly survey myriad types of microbial organisms, both procaryote and eucaryote, using a phylogenetic framework to organize the concept of "biodiversity." Emphasis will be on the evolutionary development of the many biochemical themes, how they mold our biosphere, and the organisms that affect the global biochemistry. Molecular mechanisms that occur in different lineages will be compared and contrasted to illustrate fundamental biological strategies. Graduate students additionally should enroll in C216, Microbial Diversity Workshop.Microbial Diversity: Read More [+]

Rules & Requirements

Prerequisites: Upper-division standing. C112 or consent of instructor and organic chemistry (may be taken concurrently)

MCELLBI 118The Cancer Karyotype: What it is and What it Does1 Unit

Terms offered: Spring 2018, Fall 2017, Spring 2017
Mutational cancer theories do not explain why cancers: 1) have clonal individual karyotypes; 2) have polygenic transcriptomes and phenotypes; 3) have flexible karyotypes, which evolve progressive malignancy and drug resistance, but maintain autonomy and even immortality; and 4) Why carcinogens induce cancer only after conspicuously long latent periods of years to decades. To answer these questions, this course tests a new karyotypic theory, which postulates that cancers evolve much like new species.The Cancer Karyotype: What it is and What it Does: Read More [+]

MCELLBI 130Cell and Systems Biology4 Units

Terms offered: Spring 2018, Spring 2017, Fall 2009
This course will provide a detailed discussion of a wide range of topics in cell biology emphasizing experimental approaches and key experiments that have provided important insights. The course is aimed at conveying an understanding of how cellular structure and function arise as a result of the properties of cellular macromolecules. An emphasis will be placed on the dynamic nature of cellular organization and will include a description of physical properties of cells (dimensions, concepts of free energy, diffusion, biophysical properties). Students will be introduced to quantitative aspects of cell biology and a view of cellular function that is based on integrating multiple pathways and modes of regulation (systems biology).Cell and Systems Biology: Read More [+]

MCELLBI 132Biology of Human Cancer4 Units

Terms offered: Fall 2017, Fall 2016, Fall 2015
The course is designed for students interested in learning about the molecular and cell biology of cancer and how this knowledge is being applied to the prevention, diagnosis and therapy of cancer. Topics covered include tumor pathology and epidemiology; tumor viruses and oncogenes; intracellular signaling; tumor suppressors; multi-step carcinogenesis and tumor progression; genetic instability in cancer; tumor-host interactions; invasion and metastasis; tumor immunology; cancer therapy.Biology of Human Cancer: Read More [+]

MCELLBI 137LPhysical Biology of the Cell3 Units

Terms offered: Spring 2017
Biology is being revolutionized by new experimental techniques that have made it possible to measure the inner workings of molecules, cells and multicellular organisms with unprecedented precision. The objective of this course is to explore this deluge of quantitative data through the use of biological numeracy. We will develop theoretical models that make precise predictions about biological phenomena. These predictions will be tested through the hands-on analysis of experimental data and by performing numerical simulations using Matlab.

MCELLBI 143Evolution of Genomes, Cells, and Development3 Units

Terms offered: Fall 2016, Fall 2015, Fall 2014
This course is intended for upper-division undergraduates seeking an interactive course based on modern concepts in evolution and comparative genomics. The course will emphasize the contribution of molecular evolution to a series of seminal events in life's history: origin of life; origin of cells; origin of eukaryotes; origin of multicellularity; evolution of animal development; human origins.Evolution of Genomes, Cells, and Development: Read More [+]

MCELLBI C148Microbial Genomics and Genetics4 Units

Terms offered: Spring 2018, Spring 2017, Spring 2016
Course emphasizes bacterial and archaeal genetics and comparative genomics. Genetics and genomic methods used to dissect metabolic and development processes in bacteria, archaea, and selected microbial eukaryotes. Genetic mechanisms integrated with genomic information to address integration and diversity of microbial processes. Introduction to the use of computational tools for a comparative analysis of microbial genomes and determining relationships among bacteria, archaea, and microbial eukaryotes.Microbial Genomics and Genetics: Read More [+]

MCELLBI 149The Human Genome3 Units

Terms offered: Spring 2018, Spring 2016, Spring 2015
This is an upper division course for majors in MCB with an interest in an in-depth exploration of the forces that shape the human genome and the human population, as well as the ways that human genetic information can be used in medicine, ancestry and forensics. The course will combine lectures and discussion of research papers.The Human Genome: Read More [+]

MCELLBI 150Molecular Immunology4 Units

Terms offered: Spring 2018, Fall 2017, Spring 2017
Fundamentals of immunology with emphasis on biochemical and molecular approaches to study of the immune system and its application in medicine and biotechnology. Topics covered include description of the immune system, antibody and T-cell receptor structure and function, genes of the immunoglobulin superfamily, cells and molecular mediators that regulate the immune response, allergy, autoimmunity, immunodeficiency, tissue and organ transplants, and tumor immunology.Molecular Immunology: Read More [+]

MCELLBI 165Neurobiology of Disease3 Units

Terms offered: Spring 2018, Spring 2017, Spring 2016
The molecular, cellular, and neural circuit basis of neurological disease. Includes neurochemistry and reward systems, neural development and its disorders, addiction, neurodegenerative and neuropsychiatric disorders. Students will read and discuss primary papers from the research literature.Neurobiology of Disease: Read More [+]

Terms offered: Fall 2012, Fall 2011, Fall 2010
Course consists of a weekly three-hour training session that focuses on laboratory techniques, instructional aids, and problem solving, plus an additional three-hour weekly laboratory where the UGSI is required to assist a GSI in the instruction of laboratory (answering questions, providing demonstrations, etc.). Students will be graded on lecture and laboratory attendance and preparation of one quiz.Undergraduate Teaching of Molecular and Cell Biology 32 Laboratory: Read More [+]

Rules & Requirements

Prerequisites: 32, 136, or Integrative Biology 132 and Molecular and Cell Biology 32L or Integrative Biology 132L laboratory courses in physiology with minimum grades of B. Appointment as a UGSI in physiology by consent of instructor

Repeat rules: Course may be repeated for a maximum of 4 units.Course may be repeated for a maximum of 4 units.

Terms offered: Summer 2017 3 Week Session
This 1-week workshop will focus on applications of CRISPR technology as a platform for genome editing and functional genomics. The program will consist of lectures from experts in the field and a hands-on laboratory experience demonstrating targeted mutagenesis in cultured human cells. Workshop faculty will address topics in genome editing and CRISPR-Cas9 research, including basic and enhanced CRISPR methods, cellular repair mechanisms, regulation of gene expression, bioinformatics, applications to various organisms, and bioethics.IGI CRISPR Workshop: Practical Aspects of Precision Biology for Undergraduates: Read More [+]

Rules & Requirements

Prerequisites: Any one of the lab courses (MCB 110L, 133L, 140L, 150L and 160L) or equivalent lab experience

Terms offered: Fall 2017
UGSIs will work under supervision of instructor and/or GSI. The UGSI will attend three hours of lecture per week and one hour or two hours of discussion section a
week depending on the number of units, where they will assist a GSI in instruction (answering questions, providing demonstrations, facilitating activities, etc.). In addition, UGSIs
will meet with students from their section for one or two hours of tutoring per week depending on the number of units. UGSIs do not evaluate students' work or assign grades. UGSIs will be
graded on lecture and discussion attendance and preparation of one lesson plan and one quiz. Required to attend any mandatory preparatory and review meetings.Undergraduate Student Instructor for Molecular and Cell Biology Courses: Read More [+]

Rules & Requirements

Prerequisites: Must have completed course applying to UGSI with a grade of B or better; or consent of instructor

MCELLBI H196AHonors Research1 - 4 Units

Terms offered: Fall 2015, Fall 2014, Spring 2013
Individual research and thesis preparation under the supervision of a faculty member. Acceptance to the Molecular and Cell Biology Honors Program is required. Contact the MCB Undergraduate Affairs Office, 3060 Valley Life Sciences Building, for application and details. Honor students must complete at least two semesters of research, taking a minimum of 4 units and a maximum of 8 units of H196A-196B. If desired, one semester of 199 can be used to replace H196A.Honors Research: Read More [+]

MCELLBI H196BHonors Research1 - 4 Units

Terms offered: Spring 2016, Spring 2015, Spring 2014
Individual research and completion of thesis under the supervision of a faculty member. This course satisfies the thesis requirement for the Molecular and Cell Biology Department Honors Program. Contact the MCB Undergraduate Affairs Office, 3060 Valley Life Sciences Building, for program details and an application. Honor students must complete at least two semesters of research, taking a minimum of 4 units and a maximum of 8 units of H196A-196B. One semester of H196B is required.Honors Research: Read More [+]

MCELLBI 200AFundamentals of Molecular and Cell Biology3 Units

Terms offered: Fall 2017, Fall 2016, Fall 2015
The goal of this course is to provide graduate-level instruction on molecular and cellular biosciences from a highly-integrated systems perspective, rather than using a more classic, techniques-oriented format. A collection of approaches, and a focus on critical thinking and problem solving, will be used to show how fundamental, highly-significant biological problems are "cracked open." Reading will be assigned from a mix of classic and current peer-reviewed papers selected by the instructors.Fundamentals of Molecular and Cell Biology: Read More [+]

Rules & Requirements

Prerequisites: 200A and 200B must be taken concurrently. Combined course required and restricted to all MCB first-year graduate students

MCELLBI 200BFundamentals of Molecular and Cell Biology3 Units

Terms offered: Fall 2017, Fall 2016, Fall 2015
The goal of this course is to provide graduate-level instruction on molecular and cellular biosciences from a highly-integrated systems perspective, rather than using a more classic, techniques-oriented format. A collection of approaches, and a focus on critical thinking and problem solving, will be used to show how fundamental, highly-significant biological problems are "cracked open." Reading will be assigned from a mix of classic and current peer-reviewed papers selected by the instructors.Fundamentals of Molecular and Cell Biology: Read More [+]

Rules & Requirements

Prerequisites: Must be taken concurrently. Combined course required for all MCB first-year graduate students

MCELLBI 206Physical Biochemistry3 Units

Terms offered: Spring 2018, Spring 2017, Spring 2016
Application of modern physical concepts and experimental methods to the analysis of the structure, function, and interaction of large molecules of biological interest.Physical Biochemistry: Read More [+]

Rules & Requirements

Prerequisites: MCB C100A or equivalent. Admission to the course requires formal consent of instructors, except for MCB and Biophysics graduate students and graduate students in the laboratories of MCB faculty

MCELLBI C212BChemical Biology II - Enzyme Reaction Mechanisms1 Unit

Terms offered: Spring 2018, Spring 2017, Spring 2016
This course will focus on the principles of enzyme catalysis. The course will begin with an introduction of the general concepts of enzyme catalysis which will be followed by detailed examples that will examine the chemistry behind the reactions and the three-dimensional structures that carry out the transformations.Chemical Biology II - Enzyme Reaction Mechanisms: Read More [+]

Terms offered: Spring 2018, Spring 2017, Spring 2016
This course will build on the principles discussed in Chemical Biology I and II. The focus will consist of case studies where rigorous chemical approaches have been brought to bear on biological questions. Potential subject areas will include signal transduction, photosynthesis, immunology, virology, and cancer. For each topic, the appropriate bioanalytical techniques will be emphasized.Chemical Biology III - Contemporary Topics in Chemical Biology: Read More [+]

MCELLBI C216Microbial Diversity Workshop1 Unit

Terms offered: Fall 2017, Fall 2016, Fall 2015
This workshop for graduate students will parallel C116, Microbial Diversity, which should be taken concurrently. Emphasis in the workshop will be on review of research literature and formulation of paper pertinent to research in microbial diversity.Microbial Diversity Workshop: Read More [+]

Rules & Requirements

Prerequisites: Graduate standing; C112 or consent of instructor and organic chemistry (may be taken concurrently)

Terms offered: Spring 2018, Fall 2017, Spring 2017
The use of genome engineering to study cellular signaling (especially ubiquitin-mediated signals) and develop potential new therapeutics and diagnostics will be covered in research reports and reviews of the current literature and in discussion of current experiments in the field.

Terms offered: Spring 2018, Spring 2016, Spring 2003
Different methods for determining how the in situ structure and arrangement of macromolecular complexes influence cell morphology and
function will be discussed via literature review and implemented through lab-based research and discussions.

MCELLBI 219AStructural Membrane Biology2 Units

Terms offered: Spring 2018, Fall 2017, Spring 2017
The mechanisms by which protein complexes use their structures to bud, bend, and sever membranes will be covered in research reports and reviews of the current literature and in discussion of current experiments in the field.Structural Membrane Biology: Read More [+]

Rules & Requirements

Prerequisites: Enrollment is restricted to students conducting research in the laboratory of the instructor, or requires consent of instructor

Terms offered: Spring 2018, Fall 2017, Spring 2017
Methods of single molecule manipulation and visualization that are used to characterize the structure and mechanochemical properties of translocating DNA binding protein such as RNA polymerase and to investigate the mechanical denaturation of single protein molecules will be covered in research reports and reviews of the current literature and in discussion of current experiments in the field.Research Review in Biochemistry and Molecular Biology: Single Molecule Biophysics: Read More [+]

Rules & Requirements

Prerequisites: Enrollment is restricted to students conducting research in the laboratory of the instructor, or requires consent of instructor

MCELLBI 231Advanced Developmental and Stem Cell Biology4 Units

Terms offered: Spring 2018, Spring 2017, Spring 2015
Principles of animal development will be set forth from the classical and recent experimental analysis of induction, localization, patterning mutants, axis formation, regional gene expression, and cell interactions. Early development of selected vertebrates and invertebrates will be examined, and emerging topics in microRNA and stem cell biology will be highlighted. A weekly discussion section with readings from the research literature is required.Advanced Developmental and Stem Cell Biology: Read More [+]

Rules & Requirements

Prerequisites: Previous course in development (131 or equivalent) or consent of instructor

Terms offered: Spring 2018, Fall 2017, Spring 2017
Research in our lab is focused on the cell biology of mammalian fertilization. Our lab uses biophysical, biochemical, and molecular genetics methods to study sperm ion channels and transporters that regulate sperm motility, chemotaxis, and the acrosome reaction. A better understanding of these processes will eventually lead to the development of effective tools to control and preserve male fertility, improve the reproductive health of human population worldwide, and advance family planning.Research Review in Cell and Developmental Biology: The Cell Biology of Fertilization: Read More [+]

Rules & Requirements

Prerequisites: Enrollment is restricted to students conducting research in the laboratory of the instructor, or requires consent of instructor

MCELLBI C243Seq: Methods and Applications3 Units

Terms offered: Spring 2015, Spring 2014
A graduate seminar class in which a group of students will closely examine recent computational methods in high-throughput sequencing followed by directly examining interesting biological applications thereof.Seq: Methods and Applications: Read More [+]

Rules & Requirements

Prerequisites: Graduate standing in Math, MCB, and Computational Biology; or consent of the instructor

MCELLBI 249LImaging Single Molecules: Fashion or Game Changer?2 Units

Terms offered: Spring 2018, Fall 2017, Spring 2017
Research review in genetics, genomics and development. We will explore how the detection of single particles
(DNA, RNA, proteins) can help with understanding cellular organization and
enzymatic processes dynamics and kinetics. Most of the experiments
described will be drawn from the gene expression and nuclear organization
literature.Imaging Single Molecules: Fashion or Game Changer?: Read More [+]

Rules & Requirements

Prerequisites: Enrollment is restricted to students conducting research in the laboratory of the instructor, or requires consent of instructor

MCELLBI 249MMPhysical Biology of Living Organisms2 Units

Terms offered: Spring 2018, Fall 2017, Spring 2017
Research review in genetics, genomics and development. In development a single cell goes through a series of repeated divisions
and these cells read the program encoded in their DNA in order to become
familiar cell types such as those found in muscle, liver, or our brains. The
goal of our lab is to uncover the rules behind these decisions with the
objective of predicting and manipulating developmental programs from just
looking at DNA sequence. In order to reach this predictive understanding we
combine physics, synthetic biology, and new technologies to query and
control developmental decisions in real time at the single cell level in
the fruit fly embryo.Physical Biology of Living Organisms: Read More [+]

Rules & Requirements

Prerequisites: Enrollment is restricted to students conducting research in the laboratory of the instructor, or requires consent of instructor

Terms offered: Spring 2018, Fall 2017, Spring 2017
The fundamental problem of comparative genomics: the determination of the origins and evolutionary history of the nucleotides in all extant genomes. My work incorporates various aspects of genomics, including the reconstruction of ancestral genomes (paleogenomics), the modeling of genome dynamics (phylogenomics and systems biology), and the assignment of function of genome elements (functional genomics and epigenomics).Research Review in Genetics and Development: Comparative Genomics and Computational Biology: Read More [+]

Rules & Requirements

Prerequisites: Enrollment is restricted to students conducting research in the laboratory of the instructor, or requires consent of instructor

MCELLBI 249YResearch Review in Genetics and Development: Mechanisms of Gene Control in Vertebrate Animals2 Units

Terms offered: Spring 2018, Fall 2017, Spring 2017
This course will focus on mechanisms of gene control in vertebrate animals, particularly in the area of vertebrate development. Amphibian egg formation, mesoderm induction, neural induction, and patterning of the nervous system at the molecular level. Control of transcription, post-transcriptional control of gene expression (including control of RNA turnover and RNA localization).Research Review in Genetics and Development: Mechanisms of Gene Control in Vertebrate Animals: Read More [+]

Rules & Requirements

Prerequisites: Enrollment is restricted to students conducting research in the laboratory of the instructor, or requires consent of instructor

MCELLBI 251The Regulation of Immune System Development and Function1 Unit

Terms offered: Spring 2018, Fall 2017, Spring 2017
This is an advanced seminar course which will consider current research questions and experimental approaches in molecular and cellular immunology. Each registrant will present a 30-minute research talk describing the problems they are studying, the approach they are taking, their preliminary data, and technical problems. Other course participants (including basic immunology faculty) will provide criticism and suggestions.The Regulation of Immune System Development and Function: Read More [+]

MCELLBI 259AMycobacterium Tuberculosis (Mtb)2 Units

Terms offered: Spring 2018, Spring 2016, Spring 2006
The TB field has entered a new era with the convergence of genetic tools, genome sequencing, bioinformatics, advanced imaging techniques, animal models of infection, and high-throughput assays that allow us to study this multi-faceted interaction between Mtb and its host. We use all of these tools to probe the molecular and cellular events that enable M. tuberculosis to evade host defense mechanisms.Mycobacterium Tuberculosis (Mtb): Read More [+]

Rules & Requirements

Prerequisites: Enrollment is restricted to students conducting research in the laboratory of the instructor, or requires consent of instructor

Terms offered: Spring 2018, Fall 2017, Spring 2017
We will discuss macrophage biology and innate immunity in the context of infection with *Mycobacterium tuberculosis* through
discussion of current research from the Stanley Lab and both cutting edge and classic literature in relevant fields.

MCELLBI C262Circuit and Systems Neurobiology3 Units

Terms offered: Spring 2018, Spring 2017, Fall 2015
Advanced coverage of current research problems in systems-level neuroscience, and experimental and computational techniques used for these studies.Circuit and Systems Neurobiology: Read More [+]

Terms offered: Spring 2018, Fall 2017, Spring 2017
Research in our laboratory focuses on understanding how neurons use biochemical pathways to integrate diverse types of information in order to adjust synaptic strength and modulate neuronal excitability, and how these interactions go awry in disease. To investigate this we are taking a multi-disciplinary approach incorporating molecular, biochemical, imaging, and electrophysiological analyses in mouse and human cells.Research Review in Neurobiology: Molecular Mechanisms of Neuronal Plasticity: Read More [+]

Rules & Requirements

Prerequisites: Enrollment is restricted to students conducting research in the laboratory of the instructor, or requires consent of instructor

MCELLBI 290Graduate Seminar1 Unit

Terms offered: Spring 2018, Fall 2017, Spring 2017
Graduate student presentations on selected research topics in molecular and cell biology. Several sections covering different topics offered each semester. Concurrent enrollment in more than one section is permitted. List of topics to be announced before each semester.Graduate Seminar: Read More [+]

Rules & Requirements

Prerequisites: Graduate standing in the department or consent of instructor

MCELLBI 291AIntroduction to Research2 - 12 Units

Terms offered: Fall 2017, Fall 2016, Fall 2015
Closely supervised experimental work under the direction of an individual faculty member; an introduction to experimental methods and research approaches in particular areas of molecular and cell biology.Introduction to Research: Read More [+]

Grading: Letter grade. This is part one of a year long series course. A provisional grade of IP (in progress) will be applied and later replaced with the final grade after completing part two of the series.

MCELLBI 291BIntroduction to Research2 - 12 Units

Terms offered: Spring 2018, Spring 2017, Spring 2016
Closely supervised experimental work under the direction of an individual faculty member; an introduction to experimental methods and research approaches in particular areas of molecular and cell biology.Introduction to Research: Read More [+]

Terms offered: Spring 2018, Spring 2017, Spring 2016
The purpose of this course is to ensure that research trainees are well versed with respect to training in Responsible Conduct, Rigor, and Reproducibility in Research. Students also gain an understanding of federal, state, and UC Berkeley policies and resources available to further support their research endeavors. This course will cover topics in responsible conduct, rigor and reproducibility in research drawing from case studies of the Association of American Medical Colleges and the NIH. Students will review case studies in preparation for class discussion. Required of all MCB graduate and post doctoral students funded on NIH training grants. One session will probably feature a guest lecturer on a topic relevant to the course.Responsible Conduct, Rigor and Reproducibility in Research: Read More [+]

MCELLBI 293SFoundations of Biostatistical Practice1 Unit

Terms offered: Spring 2018
This course is designed to introduce students to the foundations of statistics in the context of biological research. Rather than focusing on a catalog of specific methods (by essence non-exhaustive and rapidly outdated), the course emphasizes general concepts and approaches necessary for sound statistical practice. Topics covered include: exploratory data analysis (EDA); data visualization; inferential reasoning; models and assumptions; statistical computing; computationally reproducible research. The statistical methods and software are motivated by and illustrated on data structures that arise in current biological and medical research.Foundations of Biostatistical Practice: Read More [+]

MCELLBI 295Careers for Life Sciences Ph.D's1 Unit

Terms offered: Spring 2018, Spring 2017, Spring 2016
This course is designed to assist graduate students in the biological sciences with planning their postgraduate careers. Weekly guest speakers will present their experiences on a variety of topics. Postdoctoral students are invited. Topics may include academia; job searches; setting up a laboratory; patent law/technology transfer; public policy/regulatory affairs; bioinformatics; science writing/technical support; forensic science; postdoctoral positions in industry; teaching, and other topics of interest.Careers for Life Sciences Ph.D's: Read More [+]

MCELLBI 380Teaching of Molecular and Cell Biology1 - 2 Units

Terms offered: Spring 2016, Fall 2015, Spring 2015
Teaching laboratories and/or discussions for Molecular and Cell Biology courses: analysis of specific format and problems. Two units of credit for those with 50% teaching appointment; one unit of credit for those with 25% teaching appointment.Teaching of Molecular and Cell Biology: Read More [+]

Rules & Requirements

Prerequisites: Appointment as graduate student instructor or consent of instructor

Repeat rules: Course may be repeated for a maximum of 4 units.Course may be repeated for a maximum of 4 units.

MCELLBI 602Individual Study for Doctoral Students1 - 8 Units

Terms offered: Spring 2006, Spring 2005, Fall 2004
Individual study in consultation with the major field adviser. Intended to provide an opportunity for qualified students to prepare themselves for the various examinations required of candidates for the Ph.D.Individual Study for Doctoral Students: Read More [+]

Rules & Requirements

Prerequisites: Restricted to Ph.D. candidates

Credit Restrictions: Course does not satisfy unit or residence requirements for doctoral degree.

When you print this page, you are actually printing everything within the tabs on the page you are on: this may include all the Related Courses and Faculty, in addition to the Requirements or Overview. If you just want to print information on specific tabs, you're better off downloading a PDF of the page, opening it, and then selecting the pages you really want to print.