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Description

Overview

A cell-permeable pyrazolopyrimidine that selectively inhibits MRP1. It is shown to increase the efficacy of vincristine and etopiside by 10- to 15-fold and 7- to 10-fold, respectively, over either of these two MRP1 substrate drugs alone in murine models of neuroblastoma (syngenic and human xenografts). As opposed to the majority of inhibitors of multidrug transporters, it is demonstrated that Reversan was not toxic by itself nor did it increase the toxicity of chemotherapeutic drug exposure in mice. Therefore, Reversan represents a new class of nontoxic MRP1 inhibitor, which may be a useful research tool for the study of neuroblastoma and other MRP1-overexpressing drug-refractory tumors.

Catalogue Number

475730

Brand Family

Calbiochem®

Synonyms

Multidrug Resistance Protein 1 Inhibitor, Reversan

References

References

Burkhart, C.A., et al. 2009. Cancer Res.69, 6573.

Product Information

Form

Pale yellow solid

Hill Formula

C₂₆H₂₇N₅O₂

Chemical formula

C₂₆H₂₇N₅O₂

Structure formula Image

Applications

Biological Information

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information

Ship Code

Blue Ice Only

Toxicity

Standard Handling

Storage

+2°C to +8°C

Do not freeze

Ok to freeze

Special Instructions

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information

Transport Information

Supplemental Information

Specifications

Documentation

SDS

Certificates of Analysis

Title

Lot Number

475730

Enter Lot Number

References

Reference overview

Burkhart, C.A., et al. 2009. Cancer Res.69, 6573.

Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision

03-December-2010 RFH

Synonyms

Multidrug Resistance Protein 1 Inhibitor, Reversan

Description

A cell-permeable pyrazolopyrimidine that selectively inhibits MRP1. It is shown to increase the efficacy of vincristine and etopiside by 10- to 15-fold and 7- to 10-fold, respectively, over either of these two MRP1 substrate drugs alone in murine models of neuroblastoma (syngenic and human xenografts). As opposed to the majority of inhibitors of multidrug transporters, it is demonstrated that Reversan was not toxic by itself nor did it increase the toxicity of chemotherapeutic drug exposure in mice. Therefore, Reversan represents a new class of nontoxic MRP1 inhibitor, which may be a useful research tool for the study of neuroblastoma and other MRP1-overexpressing drug-refractory tumors.

Form

Pale yellow solid

Chemical formula

C₂₆H₂₇N₅O₂

Structure formula

Solubility

DMSO (10 mg/ml)

Storage

+2°C to +8°C

Do Not Freeze

Ok to freeze

Special Instructions

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.