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*** Exercise Your Right to Vote ***

Important Notice Regarding the Availability of Proxy Materials for the

Stockholder Meeting to Be Held on May 31, 2019.

MINERVA NEUROSCIENCES,
INC.

MINERVA NEUROSCIENCES, INC.

1601 TRAPELO ROAD, SUITE 286

WALTHAM, MA 02451

Meeting Information

Meeting Type:

Annual Meeting

For holders as of:

April 5, 2019

Date: May 31, 2019 Time: 8:00 AM EDT

Location:

The Offices of Cooley LLP

500 Boylston Street

14th Floor

Boston, MA 02116-3736

You are receiving this communication because you
hold shares in the company named above.

This is not a ballot. You cannot use this notice to vote these shares. This communication presents only an
overview of the more complete proxy materials that are available to you on the Internet. You may view the proxy materials online at www.proxyvote.com or easily request a paper copy(see reverse side).

We encourage you to access and review all of the important information contained in the proxy materials before voting.

See the reverse side of this notice to obtain proxy materials and voting instructions.

 Before You Vote 

How to Access the Proxy Materials

Proxy Materials Available to VIEW or RECEIVE:

NOTICE AND PROXY STATEMENT ANNUAL REPORT

How to View Online:

Have the information that is printed in the box marked by the arrow
(located on the following page) and visit: www.proxyvote.com.

How to Request and Receive a PAPER or E-MAIL Copy:

If you
want to receive a paper or e-mail copy of these documents, you must request one. There is NO charge for requesting a copy. Please choose one of the following methods to make your request:

1) BY INTERNET:

www.proxyvote.com

2) BY TELEPHONE:

1-800-579-1639

3) BY E-MAIL*:

sendmaterial@proxyvote.com

*

If requesting materials by e-mail, please send a blank e-mail with the information that is printed in the box marked by the arrow
(located on the following page) in the subject line.

Requests, instructions and other
inquiries sent to this e-mail address will NOT be forwarded to your investment advisor. Please make the request as instructed above on or before May 19, 2019 to facilitate timely delivery.

 How To Vote 

Please Choose One of the Following Voting Methods

Vote In Person: Many stockholder meetings have attendance requirements including, but not limited to, the possession of an
attendance ticket issued by the entity holding the meeting. Please check the meeting materials for any special requirements for meeting attendance. At the meeting, you will need to request a ballot to vote these shares.

Vote By Internet: To vote now by Internet, go to
www.proxyvote.com. Have the information that is printed in the box marked by the arrow
(located on the following page) available and follow the instructions.

Vote By Mail: You can vote by mail by requesting a paper copy of the materials, which will include a proxy card.

Voting Items

The Board of Directors recommends you

vote FOR the following:

1.

Election of Directors

Nominees:

01) Dr. Remy Luthringer

02) Dr. Fouzia Laghrissi-Thode

03) Jeryl Hilleman

The Board of Directors recommends you vote FOR the following proposal:

2.

To ratify the appointment of Deloitte & Touche LLP as the Company's independent registered public accounting
firm for the fiscal year ending December 31, 2019.

NOTE: Such other business as may properly come before the
meeting or any adjournment thereof.