We without the e up

When Lupe says throw We without the e up, he is alluding to the West-side symbol used in the East Coast-West Coast battles of 1990s Hip-Hop music. For Lupe, he is from the West-side of Chicago so the W has meaning to him as well. At the same time, Snoop is one of the originators of the West-side sign, so Lupe is paying tribute to the artists that inspired him when he was first learning to rap