Archivio digitale delle tesi discusse presso l'Università di Pisa

Tesi etd-08292014-115425

Synthesis of Ruthenium and Osmium Complexes with potential anticancer activity

Struttura

CHIMICA E CHIMICA INDUSTRIALE

Corso di studi

CHIMICA INDUSTRIALE

Commissione

relatore Dott. Marchetti, Fabio

Parole chiave

NAMI

osmium arene

ruthenium arene

anticancer

Data inizio appello

18/09/2014;

Consultabilità

completa

Riassunto analitico

Aim of the work

This work is focused on the synthesis of new Ru and Os complexes with potential anticancer activity. The design of the new compounds has been based on metal frames bearing structures with ascertained anticancer activity (ruthenium , and osmium arenes, simil-NAMI , ); such metal frames have been associated with newly prepared suitable ligands.The new ligands have been designed and obtained by coupling a skeleton containing one heteroatom (N or P), able to coordinate Ru and Os centers, with a fragment derived from ethacrynic acid . In particular, pyridines and PPh3 have been used to the purpose, since both types of compounds have been reported to act as enhancers of antiproliferative activity.The synthesis of the Os complexes has been carried out at the University of Zaragoza (E), under the supervision of Prof. M. A. Esteruelas.The anticancer activity of the prepared Ru and Os complexes will be tested at the École Polytechnique Fédérale de Lausanne (EPFL).