X030642018-12-0300001453814Medidata Solutions, Inc.MDSO0001641826Bergmann RouvenC/O MEDIDATA SOLUTIONS, INC.350 HUDSON STREET, 9TH FLOORNEW YORKNY100140100Chief Financial OfficerCommon Stock2018-12-034M01000053.29A88862DCommon Stock2018-12-034S01000079D78862DStock Option (right to buy)53.292018-12-034M0100000D2025-05-13Common Stock10000.017643DThe transaction reported in this Form 4 was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on July 26, 2018.The options vested as to 25% of the shares on May 13, 2016 and 1/36th of the remaining options will become exercisable each month thereafter for the next 36 months./s/ Michael I. Otner, Attorney-in-Fact2018-12-04