Analysis of CASP9 targets and predictions

These web pages present the analysis of CASP9 targets and
predictions by the
Grishin lab.
Only 3D models (TS: Tertiary structure prediction) were used here, other types of predictions, such as
high-resolution, disorder, or function, were not considered. Predictions were
evaluated using LGA
GDT-TS scores and several other methods. Targets were analyzed individually for their sequence-structure properties and prediction quality. PDB structures of targets were
modified
to match target sequences, and evolutionary domains
were deduced from structures. Evaluation of predictions was performed on both
domains and whole chains of targets, and the effects of domain parsing on the evaluation
were examined.
NMR structures were
processed
for evaluation, poorly structured regions being removed. Server
models superimposed with target structures can be downloaded and visualized as
PyMOL scripts.

Acknowledgments:
We are grateful to: CASP organizers
for their vision and leadership;
structural biologists, in particular PSI consortia,
who generously provided structures for CASP9;
and predictors who developed servers that generated
predictions making this work possible.

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