Friday, November 1, 2013

Does Mindfulness Act Through Modulation of Serotonergic Circuitry?

Investigating the connections between mindfulness meditation and the brain's serotonergic systems seems like a promising avenue of research. Mindfulness may be a way to directly influence this system based on observations from several domains.

1) A bedrock principle of psychopharmacology is that increasing the amount of serotonin in synapses improves depression and anxiety.

2) Acute doses of HT2A agonists (e.g. psilocybin) can also improve depression. These agents produce brief and intense sensory experiences. At low doses, subjects do not report hallucinations, but do report that sensations seem more intense and more affectively pleasant (e.g., colors are brighter).

Many of the measures correlating mindfulness meditation to outcome concern decreased rumination. To that end, the introspective among us should take note of this quote from a 2013 paper by Paul et al in Social Cognitive and Affective Neuroscience: "Our results suggest non-reactivity to inner experience is the key facet of mindfulness that protects individuals from psychological risk for depression."

Words to Live By

"...there is good and bad speculation, and this is not an unparalleled activity in science...Those scientists who have no taste for this sort of speculative enterprise will just have to stay in the trenches and do without it, while the rest of us risk embarrassing mistakes and have a lot of fun." - Dan Dennett