Gene Variant Detail

FBXW7 S582L lies within WD repeat 6 of the Fbxw7 protein (UniProt.org). S582L has been identified in the scientific literature (PMID: 25450649, PMID: 28120820, PMID: 28424412), but has not been biochemically characterized and therefore, its effect on Fbxw7 protein function is unknown (PubMed, May 2019).