Importance: Allergic rhinitis affects about 20% of the population worldwide. Available pharmacological treatments are helpful but not ideal in providing relief; safer and more effective treatments are needed.
Objective: To evaluate the efficacy and safety of Nasapaque nasal solution vs placebo for relief or prophylactic treatment of seasonal allergic rhinitis. ...

Calendula offi cinalis is a plant belonging to the Asteraceae family. Herbal preparations from Calendula
have been used topically as a natural anti-infl ammatory medicine and for the healing of wounds and
leg ulcers. Although data on dermal irritation and sensitization are available, the risk of subchronic
systemic toxicity following dermal application of Calendula ...