About

The Molecular Biology Core occupies 2,600 square feet in the Stabile Building at Mayo Clinic in Rochester, Minn. Personnel include 11 full-time staff members, five of whom each have more than 15 years of molecular biology laboratory experience.

For the past 20 years, the core has sequenced an average of 100,000 to 150,000 samples a year using Sanger sequencing. In 2012, the Molecular Biology Core processed more than 7,000 next-generation sequencing samples. The core can sequence 12 eight-lane flow cells a week using its six Illumina HiSeq 2000 sequencers.

To date, thousands of samples have been analyzed using:

Whole-genome sequencing

Targeted sequencing (whole-exome and custom capture using SureSelect by Agilent)

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