LASH or large-and-small-hole baffle is a new kind of baffle which induces axial flow in the shell-side of heat exchangers. In this paper, pressure drop and heat transfer of heat exchangers with LASH baffles were experimentally studied and compared with those in common heat exchangers with segmental baffle. It is founded that compared with the segmental baffles, pressure drops caused by LASH baffles are greatly decreased. Although the shell-side heat transfer coefficient with the LASH baffles is decreased, more comprehensive performance for heat exchangers with LASH baffles can be achieved.