Anti-ulcerogenic and gastric anti-secretory activity of aqueous extract of Cochorus olitorius was investigated in HCl/ethanol and indomethacin-induced gastric lesions in male albino rats. Pre-treatment with aqueous extract (50, 100, or 200 mg.kg−1) orally for 2 weeks reduced ulcer formation, except those pre-treated with 50 mg.kg− in the indomethacin model. In both models, the decrease in gastric acid production was dose-dependent