Related items

The Ts65Dn mouse is the most-studied murine model for Down syndrome (DS) or
trisomy 21. Homology between triplicated murine genes and genes on human
chromosome 21 (Hsa21) correlates with the shared anomalies of Ts65Dn ...

Ts65Dn is the mouse model most widely used in Down syndrome (DS) research. In this model, triplication of the distal portion of mouse chromosome 16 (MMU16), which contains orthologs to genes on human chromosome 21, results ...

The Ts65Dn mouse model for Down syndrome (DS) has triplication of more than half of the mouse genes orthologous to those on human chromosome 21, and exhibits many phenotypes characteristic of human DS. Previous gross ...