Good hint. I'm sure I did disable Fast Boot when I did the first installation. But as mentioned in the linked article "In a post on the PC Master Race subreddit, a user pointed out that fast startup was re-enabled in a Windows 10 update following the release of the Fall Creators Update." So I will check tonight.

If you check, whether you need one or multiple clicks to boot the NUC, you need to wait a little while between Shut Off and Power On. If you restart immediately, one click will do. But after a while (several minutes), you will need two clicks (at least with Power Toggle).

Which BIOS version are you testing? And which is your CIR driver version?