In "Transwarped", after Sari realizes that she is not human, Optimus attempts to have Professor Isaac Sumdac and Sari reconcile with each other. Later, they encounter Masterson, who is piloting his headmaster unit on Starscream's decapitated body. He defeats Masterson by tricking him to transform into vehicle mode, which was impossible due to with the Headmaster unit on Starscream's body. Later still, during a melee with a rock creature that found its way to Earth when Bumblebee returned from his accidental transwarp, Optimus struggles to stop Sari, who goes out of control after using her key to upgrade herself.
Optimus and Prowl received message from Skyfire of a coal transport in Africa, and discovered Megatron was using human slaves. Megatron detonated his coal mines with the world's largest explosion, killing the humans and forging the world's largest diamond — that he would use to as a lens for a satellite to focus the Sun's beams, melting the Rocky Mountains! Prime ordered Skyfire to attack the satellite, and Ratchet to build a square mile panel of metal to deflect the beam, blowing the satellite up. Satellite of Doom The Decepticons attempted to drain the Prudhoe Bay oil reservoir, causing volcanic eruptions and Russia to approach America, accelerating tensions between the countries. Optimus ordered razon gas to be pumped into the reservoir, returning the oil below and raising the Decepticons' aquatic drill. When Continents Collide

Power of the Primes "Evolution Optimus Prime" transforms from a truck with a trailer into a robot and back. The individual truck transforms into his "Orion Pax" form based on his appearance in the Generation 1 episode "War Dawn", and he is able to form the core of Optimus Prime's robot mode. His trailer forms Prime's entire body, and his ion blaster can be split into two weapons. He includes the Matrix of Leadership, which can store in his chest in the 'Evolved' form. The center of his Matrix of Leadership can be replaced with any Prime Master. In an undocumented feature, his rifle can be stored on his back as Optimus Prime by pegging it into Orion Pax's hands.The Takara version of the mold lacks the production numbers located at his right shins. Depending on the individual copy, Optimus Prime is prone to having a number of quality control issues: ranging from two left/right arms and/or legs/feet on the evolution armor, to lacking stickers on the trailer pieces.

Released as part of TakaraTomy's Transformers Movie The Best toyline to conclude the 10th anniversary of the live-action film series, this Optimus Prime is an extensive redeco of his Evasion mode toy. He also uses the faceplated head and the dark gray-colored Ion Cannon used for the Evolution 2-pack/Platinum Edition 5-pack release. While his deco had taken cues from both the TakaraTomy release of Evasion Mode Optimus Prime and the Platinum Edition Breakout Battle figure, the weathering pattern bears a similar resemblance to his rusty version of the figure. Unfortunately, this release suffers from heavy mold degradation, particularly in the form of ill-fitting tabs around the truck front/shoulder area.
Part of the first wave of TakaraTomy Lost Age: Movie Advanced toys, this Japanese-exclusive redeco of 2007 Transformers Protoform Optimus Prime is given a Generation 1-styled color scheme (which is also based on his appearances in IDW's Transformers: Foundation comic-book mini-series). Protoform Optimus Prime transforms into his "entry" mode. This mode somewhat resembles a cybertronic truck, with false wheels sculpted onto the sides, and Optimus Prime's trademark windows in front. His now-blue flame decoration piece fits to the back of the "vehicle", creating the illusion of a flaming comet's tail (Not sure if this was mean to represent his jetpack blast effect or his atmospheric entry heat effect, which is for no reason: entirely blue instead of hot red). The bottom of the vehicle has small wheels to roll the toy across smooth surfaces.