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Claims for Patent: 4,307,100

Claims for Patent: 4,307,100

Title:

Nor bis-indole compounds usable as medicaments

Abstract:

Compounds with antitumoral activity corresponding to the formula (I): ##STR1## wherein R'.sub.1 is a hydrogen atom or an alkoxy, acyl, formyl or haloacyl radical; R'.sub.2 is a hydrogen atom or an alkyl radical; R'.sub.3 and R".sub.3 are a hydrogen atom, hydroxyl radical or an alkanoyloxy radical, and together are a carbonyl group, and R'.sub.3 and R'.sub.5 together are an epoxy bridge or a double bond; R'.sub.4 is a hydrogen atom or an alkyloxycarbonyl, hydroxymethyl, alkanoyloxymethyl or acetamido radical; R'.sub.5 and R".sub.5 are a hydrogen atom or a hydroxyl, alkanoyloxyl, ethyl or 2-hydroxyethyl radical; R'.sub.6 is a hydrogen atom or an ethyl, 2-hydroxyethyl or acetyl radical; R.sub.1 is a hydrogen atom or an alkyl, formyl or acyl radical; R.sub.2 is a hydrogen atom or alkoxy radical; R.sub.3 is a hydrogen atom or a hydroxyl or alkanoyloxyl radical, and together with R.sub.4 is an epoxy bridge or a double bond; R.sub.4 is a hydrogen atom or a hydroxyl, alkanoyloxyl radical, and together with R.sub.5 is an epoxy bridge; R.sub.6 is an alkyloxycarbonyl, hydrazido, acetamido, hydroxymethyl or alkanoyloxymethyl radical; and R.sub.5 and R.sub.7 are a hydrogen atom or a hydroxyl and alkanoyloxyl radical; acid addition and quaternary ammonium salts thereof and 12-chloro derivatives thereof.

1. Compounds corresponding to the following formula (I): ##STR18## wherein R'.sub.1 is selected from the group consisting of a hydrogen atom and an alkoxy, acyl, formyl and
haloacyl radical, said alkoxy radical containing from 1 to 5 carbon atoms, said acyl and haloacyl radical containing from 2 to 5 carbon atoms;

R'.sub.2 is selected from the group consisting of a hydrogen atom and an alkyl radical, said alkyl radical containing from 1 to 5 carbon atoms;

R'.sub.3 and R".sub.3 are independently selected from the group consisting of a hydrogen atom and a hydroxyl radical and an alkanoyloxy radical, said alkanoyloxy radical containing from 2 to 5 carbon atoms, and together are an oxo group, and
R'.sub.3 and R'.sub.5 together are an epoxy bridge or a double bond;

R'.sub.4 is selected from the group consisting of a hydrogen atom and an alkyloxycarbonyl, hydroxymethyl, alkanoyloxymethyl and acetamido radical;

R'.sub.5 and R".sub.5 are independently selected from the group consisting of a hydrogen atom and a hydroxyl, alkanoyloxyl, ethyl and 2-hydroxyethyl radical, said alkanoyxloxyl radical having from 2 to 5 carbon atoms;

R'.sub.6 is selected from the group consisting of a hydrogen atom and an ethyl, 2-hydroxyethyl and acetyl radical;

R.sub.1 is selected from the group consisting of a hydrogen atom and an alkyl, formyl and acyl radical, said alkyl radical having from 1 to 5 carbon atoms, said acyl radical having from 2 to 5 carbon atoms;

R.sub.2 is selected from the group consisting of a hydrogen atom and alkoxy radical, said alkoxy radical containing from 1 to 5 carbon atoms;

R.sub.3 is selected from the group consisting of a hydrogen atom and a hydroxyl and alkanoyloxyl radical, said alkanoyloxyl radical containing from 2 to 5 carbon atoms, and together with R.sub.4 is selected from the group consisting of an epoxy
bridge and a double bond;

R.sub.4 is selected from the group consisting of a hydrogen atom and a hydroxyl, alkanoyloxyl radical of from 2 to 5 carbon atoms, and together with R.sub.5 is an epoxy bridge;

R.sub.6 is selected from the group consisting of an alkyloxycarbonyl, hydrazido, acetamido, hydroxymethyl and alkanoyloxymethyl radical; and

R.sub.5 and R.sub.7 are selected from the group consisting of a hydrogen atom and a hydroxyl and alkanoyloxyl radical of from 2 to 5 carbon atoms;

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