At Tumor Oxygen Levels, mTOR Is Loner, Complicating Targeting

By Anette BreindlScience Editor

Friday, March 29, 2013

By using a single-cell proteomics approach, researchers have discovered that the mammalian target of rapamycin, or mTOR protein, may be hardest to drug at oxygen levels that are often found in tumors. In the most practical sense, the work may help explain why the clinical success of inhibiting mTOR has been mixed.