Jonathan Cooper

Our lab studies signaling events that control the architecture of
the developing brain. We use biochemistry, cultured neurons and gene
targeting in mice to dissect the mechanisms that coordinate neuron
migrations during development of the cortex and other brain regions.
We are particularly interested in the roles of protein
phosphorylation and the ubiquitin-proteasome pathway. Methods
include mouse knockouts, neuronal cultures, RNA interference, in
utero electroporation and immunocytochemistry.

Migrating neocortical neurons, labeled by in utero
electroporation and imaged using time-lapse confocal microscopy in a
brain slice