Reference Data

The RANBP2-like and GRIP domain containing 5 protein (RGPD5) has high similarity to RANBP2, a large RAN-binding protein localized at the cytoplasmic side of the nuclear pore complex. The gene coding for RGPD5 is thought to have arisen from a gene duplication event of RANBP2 as these highly homologous genes are located close to each other at chromosome 2q11-q12. RGPD5 was identified as an HIV dependency factor (HDF), suggesting that RGPD5 may be an important drug target in HIV treatment. At least two isoforms of RGPD5 are known to exist, of which the shorter isoform is expressed primarily in testis, while the longer of the two is expressed at low levels in a number of somatic tissues.