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Much of the early mortality seen in multiple sclerosis patients is related to their smoking habits, a researcher said here.

In a prospectively followed cohort of nearly 900 MS patients, 68% of those who died in a 40-year period were current or former smokers, compared with 50% of surviving patients, according to Ali Manouchehrinia of the University of Nottingham in England.

After adjusting for sex, age of MS onset, initial diagnosis (relapsing versus progressive MS), and use of disease-modifying drugs, the hazard ratio for death among ever-smokers versus lifetime nonsmokers was 2.13 (95% CI 1.26 to 3.61, P=0.005), he told attendees at the European Committee for Treatment and Research in Multiple Sclerosis annual meeting.

The mortality rate in ever-smokers was 5.48 per 1,000 person-years, compared with 2.30 per 1,000 person-years among the lifetime nonsmokers in the cohort.

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