Abstract

Lactic acid-producing bacteria are associated with various plant and animal niches and play a key role in the production of fermented foods and beverages. We report nine genome sequences representing the phylogenetic and functional diversity of these bacteria. The small genomes of lactic acid bacteria encode a broad repertoire of transporters for efficient carbon and nitrogen acquisition from the nutritionally rich environments they inhabit and reflect a limited range of biosynthetic capabilities that indicate both prototrophic and auxotrophic strains. Phylogenetic analyses, comparison of gene content across the group, and reconstruction of ancestral gene sets indicate a combination of extensive gene loss and key gene acquisitions via horizontal gene transfer during the coevolution of lactic acid bacteria with their habitats.

abstract = "Lactic acid-producing bacteria are associated with various plant and animal niches and play a key role in the production of fermented foods and beverages. We report nine genome sequences representing the phylogenetic and functional diversity of these bacteria. The small genomes of lactic acid bacteria encode a broad repertoire of transporters for efficient carbon and nitrogen acquisition from the nutritionally rich environments they inhabit and reflect a limited range of biosynthetic capabilities that indicate both prototrophic and auxotrophic strains. Phylogenetic analyses, comparison of gene content across the group, and reconstruction of ancestral gene sets indicate a combination of extensive gene loss and key gene acquisitions via horizontal gene transfer during the coevolution of lactic acid bacteria with their habitats.",

keywords = "Evolutionary genomics, Fermentation",

author = "K. Makarova and A. Slesarev and Y. Wolf and A. Sorokin and B. Mirkin and E. Koonin and A. Pavlov and N. Pavlova and V. Karamychev and M. Polouchine and V. Shakhova and I. Grigoriev and Y. Lou and D. Rohksar and S. Lucas and K. Huang and Goodstein, {D. M.} and T. Hawkins and V. Plengvidhya and D. Welker and J. Hughes and Y. Goh and A. Benson and K. Baldwin and Lee, {J. H.} and I. D{\'i}az-Mu{\~n}iz and B. Dosti and V. Smeianov and W. Wechter and R. Barabote and G. Lorca and E. Altermann and R. Barrangou and B. Ganesan and Y. Xie and H. Rawsthorne and D. Tamir and C. Parker and F. Breidt and J. Broadbent and R. Hutkins and D. O'Sullivan and J. Steele and G. Unlu and M. Saier and T. Klaenhammer and P. Richardson and S. Kozyavkin and Weimer, {Bart C} and D. Mills",

year = "2006",

month = oct,

day = "17",

doi = "10.1073/pnas.0607117103",

language = "English (US)",

volume = "103",

pages = "15611--15616",

journal = "Proceedings of the National Academy of Sciences of the United States of America",

issn = "0027-8424",

number = "42",

}

TY - JOUR

T1 - Comparative genomics of the lactic acid bacteria

AU - Makarova, K.

AU - Slesarev, A.

AU - Wolf, Y.

AU - Sorokin, A.

AU - Mirkin, B.

AU - Koonin, E.

AU - Pavlov, A.

AU - Pavlova, N.

AU - Karamychev, V.

AU - Polouchine, M.

AU - Shakhova, V.

AU - Grigoriev, I.

AU - Lou, Y.

AU - Rohksar, D.

AU - Lucas, S.

AU - Huang, K.

AU - Goodstein, D. M.

AU - Hawkins, T.

AU - Plengvidhya, V.

AU - Welker, D.

AU - Hughes, J.

AU - Goh, Y.

AU - Benson, A.

AU - Baldwin, K.

AU - Lee, J. H.

AU - Díaz-Muñiz, I.

AU - Dosti, B.

AU - Smeianov, V.

AU - Wechter, W.

AU - Barabote, R.

AU - Lorca, G.

AU - Altermann, E.

AU - Barrangou, R.

AU - Ganesan, B.

AU - Xie, Y.

AU - Rawsthorne, H.

AU - Tamir, D.

AU - Parker, C.

AU - Breidt, F.

AU - Broadbent, J.

AU - Hutkins, R.

AU - O'Sullivan, D.

AU - Steele, J.

AU - Unlu, G.

AU - Saier, M.

AU - Klaenhammer, T.

AU - Richardson, P.

AU - Kozyavkin, S.

AU - Weimer, Bart C

AU - Mills, D.

PY - 2006/10/17

Y1 - 2006/10/17

N2 - Lactic acid-producing bacteria are associated with various plant and animal niches and play a key role in the production of fermented foods and beverages. We report nine genome sequences representing the phylogenetic and functional diversity of these bacteria. The small genomes of lactic acid bacteria encode a broad repertoire of transporters for efficient carbon and nitrogen acquisition from the nutritionally rich environments they inhabit and reflect a limited range of biosynthetic capabilities that indicate both prototrophic and auxotrophic strains. Phylogenetic analyses, comparison of gene content across the group, and reconstruction of ancestral gene sets indicate a combination of extensive gene loss and key gene acquisitions via horizontal gene transfer during the coevolution of lactic acid bacteria with their habitats.

AB - Lactic acid-producing bacteria are associated with various plant and animal niches and play a key role in the production of fermented foods and beverages. We report nine genome sequences representing the phylogenetic and functional diversity of these bacteria. The small genomes of lactic acid bacteria encode a broad repertoire of transporters for efficient carbon and nitrogen acquisition from the nutritionally rich environments they inhabit and reflect a limited range of biosynthetic capabilities that indicate both prototrophic and auxotrophic strains. Phylogenetic analyses, comparison of gene content across the group, and reconstruction of ancestral gene sets indicate a combination of extensive gene loss and key gene acquisitions via horizontal gene transfer during the coevolution of lactic acid bacteria with their habitats.