A new series of five 1-(2′,4′-difluorophenyl)-3-(substituted
phenyl)-1,3 propanediones from 2′,4′-difluorinated chalcones have been
synthesized. All the compounds (20 mg/kg po) possess anti-inflammatory
activity, as reflected by their ability to provide protection (70.00 - 93.00%) against carrageenan induced edema in rat paw. Standard indomethacin
provided 79.00% protection at the same dose. The safety of
these substituted propanediones are reflected by toxicity studies.

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