Nippostrongylus brasiliensis

About Nippostrongylus brasiliensis

The nematode Nippostrongylus brasiliensis, rat hookworm, is a gastrointestinal parasite of rats. It is one of the most widely studied helminth models: it is relatively easy to maintain in the lab and is a close relative of human hookworms.

Annotation

The gene predictions were made by the Parasite Genomics group at the Wellcome Trust Sanger Institute and WormBase, as part of the 50 Helminth Genomes Initiative (Helminth Genomes Consortium, unpublished). An in-house pipeline was developed that used MAKER to generate high-quality annotations by integrating evidence from multiple sources: ab initio gene predictions from AUGUSTUS, GeneMark-ES, and SNAP; projected annotation from C. elegans (using GenBlastG) and the taxonomically nearest reference helminth genome (using RATT); and ESTs, mRNAs and proteins from related organisms aligned to the genome using BLAST, with refinement of alignments using Exonerate.