Compared to its structural analog 2C-B, its effects are often described as being considerably more stimulating and less psychedelic with a significantly longer duration.

This compound is relatively uncommon and has little to no history of human usage prior to its 2014 distribution by online vendors as a research chemical.[1][2]

Very little data exists about the pharmacological properties, metabolism, and toxicity of BK-2C-B. As a result, users are advised to approach this novel and poorly understood hallucinogenic substance with the proper amount of precaution and harm reduction practices if choosing to use it.

History and culture

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Chemistry

βk-2C-B, or beta-keto 2C-B, is a substituted phenethylamine featuring a phenyl ring bound to an amino (NH2) group through an ethyl chain. βk-2C-B contains the structure of 2C-B substituted with a ketone group at the beta carbon of the structure (R1). βk-2C-B contains methoxy functional groups CH3O- attached to carbons R2 and R5 as well as a bromine atom attached to carbon R4 of the phenyl ring. βk-2C-B belongs to the 2C family of phenethylamines which contain methoxy groups on the 2 and 5 positions of the benzene ring.[3]

Pharmacology

Bk-2C-B likely acts as a 5-HT2Apartial agonist. The psychedelic effects are believed to come from its efficacy at the 5-HT2A receptors. However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.

Subjective effects

The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWikicontributors. These effects should be taken with a grain of salt and will rarely (if ever) occur all at once, but heavier doses will increase the chances of inducing a full range of effects. Likewise, adverse effects become much more likely on higher doses and may include serious injury or death.

Auditory effects

Toxicity and harm potential

The toxicity and long-term health effects of recreational Bk-2C-B use do not seem to have been studied in any scientific context and the exact toxic dose is unknown. This is because Bk-2C-B is a research chemical with very little history of human usage. Anecdotal evidence from people within the psychonaut community who have tried Bk-2C-B suggests that there are no negative health effects attributed to simply trying the substance by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.

Tolerance and addiction potential

As with psychedelics in general, Bk-2C-B is not habit-forming and the desire to use it can actually decrease with use. It is most often self-regulating.

Tolerance to the effects of Bk-2C-B are built almost immediately after ingestion. After that, it takes about 3 days for the tolerance to be reduced to half and 7 days to be back at baseline (in the absence of further consumption). Bk-2C-B presents cross-tolerance with all psychedelics, meaning that after the consumption of Bk-2C-B all psychedelics will have a reduced effect.