10PROTECTIVE EFFECT OF EXTRACT OF YUCCA GLORIOSA LINN. AGAINST BILATERAL CAROTID ARTERY OCCLUSION IN RATSIschemic hypoxic brain injury often causes irreversible brain damage. Lack of efficient and widely
applicable pharmacological treatments for ischemic stroke has necessitated attention towards novel traditional
medicines. Traditionally, the leaves of Yucca gloriosa Linn. is used for various diseases, including blood and
neuronal disorders. To evaluate the cerebroprotective effect of Petroleum ether extract of leaves of Yucca gloriosa
Linn. (PEYG) against the global model of ischemia in rats. In the present study, the animals were pre-treated with
PEYG for a period of 1week (250 and 500 mg/kg) p.o. The animals were anaesthetized with thiopentone sodium
(45mg/kg) and stroke was induced by Bilateral Carotid Arter y Occlusion (BCAO) for defined period with aneurism
clamps placed on both arteries and later (10 minutes) clamps were removed to allow reperfusion and animals were
then returned to their cages. After 24 hours of reperfusion, the animal behaviors were evaluated by various methods
such as behaviour pattern, Juvenile recognition, Motor activity, rotar rod test, Morris water maze test in stroke
induced animals. The treatment was continued for another week after surgery with PEYG. The present studies
suggest that, there was a decrease in the escape latency in water maze in stroke induced (negative control) group.
The group treated with 250mg/kg and 500 mg/kg PEYG showed significant (P<0.01) improvement in the
behaviour pattern, and spatial learning, which was confirmed in trial sessions in water maze test when compared
with the negative control group. In conclusion, Petroleum ether extract of leaves of Yucca gloriosa Linn. produced
cerebroprotective effects in global cerebral ischemia as evident from reduction in behavioral score, hyper
locomotion and neuronal damage.avyoops@gmail.comqResearch212012Leaves of Yucca gloriosa Linn,Bilateral Carotid Artery Occlusion,Cerebral ischemiaG. Avinash Kumar Reddy,Jyothi M JoyDepartment of Pharmacognosy and Phytochemistry, Sree Vidyanikethan College of Pharmacy, Tirupati, Andhra Pradesh -517102, India,Department of Pharmacognosy and Phytochemistry, Sree Vidyanikethan College of Pharmacy, Tirupati, Andhra Pradesh -517102, India