Chop (DDIT3) is a ubiquitously expressed mammalian gene encoding a small nuclear protein related to the CCAAT/enhancer-binding protein (C/EBP) family of transcription factors.
This gene is induced, in a wide variety of cells, by stresses such as genotoxic agents, oxidative or reductive stress and glucose deprivation which cause DNA damage or decreased function of the endoplasmic reticulum.
The 5'UTR contain three uAUG, both uAUG-1 and uAUG-2 are in-frame with the same stop codon (UGA), the thi......