Ochronosis of the prostate, a possible cause of chronic prostatitis?Alkaptonuria is a rare autosomal recessive disorder based on a wellknown gene mutation. An accumulation and oxidation of homogentisic acid does occur with dark pigmentation as a result. Clinical manifestations depend on the amount of accumulation resulting at first in a dark coloured urine with later on a cutaneous pigmentation and arthropathy. Cardiovascular and urological deposition are less frequent.This article wants to focus on the deposition in the prostate. Next to the case history of a patient with a symptomatical, recurrent prostatitis, a review of the literature with further investigations of the patient was executed. We wondered if the deposition of homogentisic acid in the prostate increases the risk of prostatitis. Also, the recent developments in treatment and/of prevention of the clinical manifestations as diet, intake of vitamin C and nitisinone are discussed.