The Windows binary is compiled with PyInstaller 2.1 and should run as x86 application on both x86 and x64 based systems.Run

Download the program archive via the button "Download ZIP" on the right sidebar

Unpack LOKI locally

Provide the folder to a target system that should be scanned: removable media, network share, folder on target system

Right-click on loki.exe and select "Run as Administrator" or open a
command line "cmd.exe" as Administrator and run it from there (you can
also run LOKI without administrative privileges but some checks will be
disabled and relevant objects on disk will not be accessible)

Reports

The resulting report will show a GREEN, YELLOW or RED result line.

Please analyse the findings yourself by:

uploading non-confidential samples to Virustotal.com

Search the web for the filename

Search the web for keywords from the rule name (e.g. EQUATIONGroupMalware_1 > search for "Equation Group")

Search the web for the MD5 hash of the sample

Please report back false positives via the "Issues" section, which
is accessible via the right sidebar (mention the false positive
indicator like a hash and/or filename and the rule name that triggered)