Precautions

If your migraine headaches are worse than they were before you started using this medicine, or your headache medicine stops working as well as it did when you first started using it. This may mean that you are in danger of becoming dependent on the headache medicine. Do not try to get better relief by increasing the dose.

If your migraine headaches are occurring more often than they did before you started using this medicine. This is especially important if a new headache occurs within 1 day after you took your last dose of headache medicine, or if you are having headaches every day. This may mean that you are dependent on the headache medicine. Continuing to take this medicine will cause even more headaches later on. Your doctor can give you advice on how to relieve the headaches.

Drinking alcoholic beverages can make headaches worse or cause new headaches to occur. People who suffer from severe headaches should probably avoid alcoholic beverages, especially during a headache.

Smoking or nicotine replacement therapy products may increase some of the harmful effects of dihydroergotamine or ergotamine. It is best to avoid smoking or the use of nicotine replacement therapy products for several hours after taking these medicines.

Dihydroergotamine and ergotamine may make you more sensitive to cold temperatures, especially if you have blood circulation problems. They tend to decrease blood flow in the skin, fingers, and toes. Dress warmly during cold weather and be careful during prolonged exposure to cold temperatures. This is especially important for older patients, who are more likely than younger adults to already have problems with their circulation.

If you have a serious infection or illness of any kind, check with your doctor before using this medicine, since you may be more sensitive to its effects.

For patients taking one of the combination medicines that contains caffeine:

Caffeine may interfere with the results of a test that uses dipyridamole (e.g., Persantine) to help find out how well your blood is flowing through certain blood vessels. You should not have any caffeine for at least 12 hours before the test.

Caffeine may also interfere with some other laboratory tests. Before having any other laboratory tests, tell the person in charge if you have taken a medicine that contains caffeine.

For patients taking one of the combination medicines that contains belladonna alkaloids, dimenhydrinate, diphenhydramine, or pentobarbital:

These medicines may cause some people to have blurred vision or to become drowsy, dizzy, lightheaded, or less alert than they are normally. These effects may be especially severe if you also take CNS depressants (medicines that slow down the nervous system, possibly causing drowsiness) together with one of these combination medicines. Some examples of CNS depressants are antihistamines or medicine for hay fever, other allergies, or colds; sedatives, tranquilizers, or sleeping medicine; prescription pain medicine or narcotics; barbiturates; medicine for seizures; muscle relaxants; and antiemetics (medicines that prevent or relieve nausea or vomiting). If you are not able to lie down for a while, make sure you know how you react to this medicine or combination of medicines before you drive, use machines, or do anything else that could be dangerous if you are dizzy or are not alert and able to see well.

Belladonna alkaloids, dimenhydrinate, and diphenhydramine may cause dryness of the mouth, nose, and throat. For temporary relief of mouth dryness, use sugarless candy or gum, melt bits of ice in your mouth, or use a saliva substitute.

Belladonna alkaloids may interfere with certain laboratory tests that check the amount of acid in your stomach. They should not be taken for 24 hours before the test.

Dimenhydrinate and diphenhydramine may interfere with skin tests that show whether you are allergic to certain substances. They should not be taken for 3 days before the test.