ISCA1 is a mitochondrial protein involved in the biogenesis and assembly of iron-sulfur clusters, which play a role in electron-transfer reactions (Cozar-Castellano et al., 2004 [PubMed 15262227]).[supplied by OMIM, Mar 2008].. Additionally we are shipping ISCA1 Antibodies (20) and many more products for this protein.

The structural plasticity of the dimeric state of the [2Fe-2S] bound form of human GRX5 (show GLRX5 Proteins) is the crucial factor that allows an efficient cluster transfer to the partner proteins human ISCA1 and ISCA2 (show ISCA2 Proteins) by a specific protein-protein recognition mechanism.

screening a human brain cDNA expression library with serum from a patient suffering from the autoimmune Sjogren's syndrome yielded a gene product called hIscA implicated in iron-sulfur cluster biogenesis

human IscA1 plays an important role in both mitochondrial and cytosolic iron-sulfur cluster biogenesis, and a notable component of the latter is the interaction between IscA1 and IOP1 (show NARFL Proteins).