The aim of this study is to evaluate whether the lesion in frontal lobe would cause the change of brain positive and negative network interaction, thereby affecting cognitive function. We employed a MSIT to compare the task-positive and DMN changes of brain tumor patients and the healthy controls. Our results indicated the interaction relationship between the task-positive and DMN in patients with brain tumor in the frontal lobe was significantly decreased. We suggest that reduced anti-correlation between DMN and task-positive networks in patients with brain tumor may be caused by dysfunctional DMN, thus affecting the cognitive function of patient.

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