Doyle trained and received a degree from the same medical school as his friend James (John Watson). During this time, James realised that literature was where Doyle would truly be distinguished. (PROSE: Prelude All-Consuming Fire)

His non-Sherlock Holmes work included the historical novels Micah Clarke and The Stark Munro Letters. In 1894, he was considerably more proud of these works but gained a new appreciation for his Holmes stories after learning that they would be remembered in the 63rd century. In contrast, Micah Clarke and The Stark Munro Letters were long forgotten. (AUDIO: The Monstrous Menagerie)

As a doctor, Doyle accompanied Redvers Fenn-Cooper on an expedition to observe giant reptiles which resembled dinosaurs, though at first he had trouble believing they existed. The implication is that this would be an inspiration for The Lost World. (TV: Ghost Light)

Doyle's resurrection in the City of the Saved was somewhat of a traumatic experience. The City itself was an affront to Doyle's beliefs on the afterlife and he found himself having to live with both of his wives from his previous life.

Jack Harkness implies in TV: Small World that such a hard-minded sceptic would have trouble accepting the Cottingley fairy photos. In reality, by the time of the Cottingley fairy hoax, Doyle fully embraced a belief in the existence of the supernatural and literally believed in fairies.

PROSE: All-Consuming Fire begins with a famous quote from a cable from William Gillette, Sherlock Holmes actor and playwright during Doyle's time, to Doyle regarding the Sherlock Holmes play he was writing, followed by Doyle's response.