This article outlines the distinctive contribution of Marxism to science studies. It traces the trajectory of Marxist ideas through the decades from the origins of Marxism to the present conjuncture. It looks at certain key episodes, such as the arrival of a Soviet delegation at the International History of Science Congress in London in 1931, as well as subsequent interactions between Marxists and exponents of other positions at later international congresses. It focuses on the impact of several generations of Marxists who have engaged with science in diverse ways. It examines the influence of Marxism on contemporary trends in science studies. It concludes that Marxism survives in circuitous and complex ways. It argues not only for a positive interpretation of its contribution in the past but for its explanatory and ethical power in the present and future.