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The U.S. Air Force often also uses that as a go-pill before flight operations. They also use methamphetamine. Just a bit of trivia. I believe Provigil is a dopamine and norepinephrine reuptake inhibitor.

It might affect the trip, but certainly not as much as, say, an SSRI would. I think you should be okay. If anything it will make you feel more awake and less dreamy, as you said. I don't believe that it would affect the potency very much, but I could be wrong, as I've never done the combination myself.

Umm.. let me put it like this: Like Major Kong here you might be in for one hell of a ride.

An acute Dopamine & Norepinephrine Reuptake Inhibitor would make the LSD importantly electric. In the early years psychedelic therapists sometimes used Ritalin for this purpose, which is an acute Dopamine Reuptake Inhibitor like Provigil (Modafinil)

Just because you dont get very high off it doesnt mean that it might mot profoundly affect the Psychedelic experience. It will behaviorally bring you into the LSD experience with an alert, aroused mindstate and that may put some !! to your trip, perhaps even more !! than you would want, so dose carefully.

Modafinil is said to be good stuff. But then again, so were methamphetamine and PCP when they were first marketed by pharm co's.

It might have a small influence or a VERY PROFOUND one, so think through how much caution you will take. LSD will not add bodily side effects, but your mind might go in overdrive.

It is an epinepherine reuptake inhibitor, triggers the release of dopamine (although this is weak and depends on the dose), MAY be an agonist for dopamine and epinerpherine, and also increases some modes of neural transmission which reduce GABA action. Therefore it is quite different from usual stimulants.

I have no clear evidence about what would happen, but i think Wiccan's guess is a good one.I don't think it would be dangerous, but not for the faint-hearted!

Quote:It is an epinepherine reuptake inhibitor, triggers the release of dopamine (although this is weak and depends on the dose), MAY be an agonist for dopamine and epinerpherine, and also increases some modes of neural transmission which reduce GABA action. Therefore it is quite different from usual stimulants.

especially with the above two you are REALLY setting yourself up for a severe anxiety reaction if you combine it with LSD, because reduced GABA is conductive to anxiety and adrenalin is an emergency substance.This isnt the "good arousal" of a noradrenalin + Dopamine reuptake inhibitor but rather something that wakes you up unpleasantly.