Louis-Dreyfus stars as Selina Meyer, the uptight, often grouchy vice president who spends most of her days juggling the political circus and putting out fires she herself has lit, and yet finds herself miraculously in the Oval Office by the end of the show's third season. Louis-Dreyfus also won an Emmy for best actress for "The New Adventures of Old Christine," and for best supporting actress for "Seinfeld." She's been nominated a total of 15 times in the acting categories.

Her competition included Lena Dunham for "Girls," Edie Falco for "Nurse Jackie," Melissa McCarthy for "Mike & Molly," Amy Poehler for "Parks and Recreation, and Taylor Schilling for "Orange is the New Black."