Ann Coulter was the subject of a slew of harsh comments on Saturday. (Mark Davis/WireImage)

Rob Lowe wasn't the only one to take some major heat at the actor's Comedy Central roast on Saturday.

Outspoken political commentator Ann Coulter was barraged with cruel comments — and at one point was even urged to commit suicide — throughout the unbridled war of words, regularly becoming the focal point of the jaw-dropping TV special.

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"Ann is one of the most repugnant, hateful, hatchet-face b-----s alive," Jimmy Carr, a British comedian, matter-of-factly proclaimed during the roast, according to Fox News. "It's not too late to change, Ann. You could kill yourself!"

Coulter, 54, was one of nine big-name participants who joined the panel to take shots at Lowe throughout the evening.

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But the tides quickly turned on the often-controversial conservative analyst, who recently released a new politically charged book titled "In Trump We Trust."

"Ann Coulter has written 11 books, 12 if you count Mein Kampf," comic Nikki Glaser deadpanned, according to USA Today. "Ann, you're awful. The only person you will ever make happy is the Mexican who digs your grave."

Legendary NFL quarterback Peyton Manning, meanwhile, didn't hold back as he hurled a pointed insult at Coulter as well.

"As you all know, earlier this year, Ann Coulter won the Kentucky Derby," the two-time Super Bowl champion joked.

But Coulter seemed to take in in stride, while making it very clear why she agreed to be on the show despite not having a history in comedy.

"I'm only here for all the love and respect I have for Rob Lowe and all of the talented performers tonight," she announced with evident sarcasm. "It has nothing to do with the book I published four days ago."

Nine big-name participants, including Coulter and Peyton Manning, joined the panel for Lowe’s roast. (Latour/Variety/REX/Shutterstock/Latour/Variety/REX/Shutterstock)

Even with the ambush on Coulter, Lowe wasn't unable to escape the roast without getting hit with some serious disses as well.

Many of the digs centered on the actor's failed TV gigs, while others focused on his infamous sex tape with a 16-year-old early on in his career.

But Lowe remained a good sport throughout.

"There are other places to do soft jokes … if you're on the Comedy Central Roast, you better bring your A-game," he said.