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Angola has an estimated 2014 population of 19.1 million, all of whom are at risk for malaria. Malaria accounts for an estimated 35 percent of mortality in children under the age of five, 25 percent of maternal mortality, and 60 percent of hospital admissions for children under five.

Malaria is the leading cause of morbidity and mortality among children under five and among pregnant women in Benin. In 2012, malaria was responsible for 26 percent of hospitalizations overall and 44 percent of hospitalizations among children under five years of age.

Malaria remains a major public health issue and is endemic throughout Burkina Faso. Insecticide resistance is increasing every year, and resistance to insecticides is evident in many parts of the country.

In Cameroon, the entire population of approximately 28 million people are at risk of malaria. Life expectancy, under-five mortality and maternal mortality in Cameroon are worse than the regional average for Central Africa. According to a 2011 household survey, one third of children under five years of age tested positive for malaria parasites.

Malaria is the leading cause of mortality among children in Côte d’Ivoire and continues to be the top reason for medical consultations and hospitalizations. Malaria is endemic throughout Côte d’Ivoire the entire year, with peaks during the rainy season. There were approximately 2.3 million presumed and confirmed malaria cases in 2015 in children under five years of age reported from health facilities.

Although considerable progress has been made in malaria control in the Greater Mekong Subregion during the past 10 years, malaria remains a major concern for the international community and ministries of health in the region.

Malaria is a major health problem in Madagascar. While malaria cases and deaths reported through the national health management information system declined over the period of 2003–2011, severe malaria remains among the top five causes of reported overall mortality.

Malaria is considered the most important public health problem in Mozambique and accounts for 29 percent of all deaths. Among children under five years old, malaria accounts for 42 percent of all deaths.

Malaria remains a major public health issue in Niger and is endemic throughout the country. Malaria accounts for 28 percent of all illnesses and 50 percent of all recorded deaths. Children under five years of age account for about 62 percent of the burden of malaria.

Sierra Leone’s entire estimated population of 6.5 million is vulnerable to malaria. More than 2 million outpatient visits due to malaria are reported malaria annually, of which half are children under five years of age.

Malaria is the leading cause of morbidity and mortality in Uganda. According to the Ministry of Health, the disease accounts for 25─40 percent of outpatient visits to health facilities and is responsible for nearly half of inpatient pediatric deaths.