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Virus is a standard plague type introduced in version 1.0. It possesses a high natural tendency to mutate traits, but struggles to neutralize said mutations, requiring a different playstyle that relies on fast enough infection to nullify any human counter-attack. The gene Darwinist best complements this natural ability, while Creationist can make the mutation rate seemingly more controllable.

Viruses are self-replicating, microscopic entities that exist on the fringes of what is known as life, having a unique set of characteristics that are not found anywhere else in our known world. They are completely dependent on living host cells to replicate, and will in fact appear completely dead if outside of their host cells.