Well - since moving the files and using the Start menu option to select new profile location, UMS keeps rebuilding it's database in the original HDD-C path (C:\ProgramData\UMS). In the startup info it does show the correct "new" path for the .conf file.

The change does not seem to stick and the database consumes just under 15GB each time, consuming all space on the - intentionally smaller - system drive.

See excerpt from log at startup of UMS...
Temp/Working directories remain on HDD-C
Profile and contents of .conf point to HDD-F
But none of these paths implicate the "space hog database" which gets continually rebuilt at C:\ProgramData\UMS

Within the Application Menu there are a number of options but these two were the initial focus...
1) Universal Media Server
2) Universal Media Server (Select Profile)

From setup UMS installed itself in the Startup folder using (1) and when UMS started this way it seemed to "reset" and place all files back on the default paths. I found that when I used the (2) option it would ask me for the db location and it did not have an issue - so I looked further into that.

I ended up creating a program shortcut as follows...
[ "C:\Program Files (x86)\Universal Media Server\UMS.exe" profile="F:\UMS Profile" ] that "starts from" [ "F:\UMS Profile" ]
and named it "StartMyUMS". (of course the entries above do not contain the square brackets)

This I then placed in my start menu (for convenience and replaced the link to (1) with my shortcut.
My HDD-C has remained happy and UMS runs as it should.

But if it's the first statement made by subjunk - it will only work with a manual start of UMS using the start menu item for selecting a profile and then navigating to the correct location to choose it. But when using the default installation of UMS - and no edits are made as I mentioned above - any reboot will simply use the default database location again. Of course you could shutdown UMS after a system restart and start it manually using the option to select a profile but that is pointless if you want to be sure UMS is available for streaming.