..After correction for baseline hippocampal volume, decline in ADL showed a significant association with right frontal horn enlargement. Executive decline was associated with right frontal and left temporal horn enlargement...

..Apathy is the most common noncognitive symptom in Alzheimer's disease (AD). The structural correlates of apathy in AD have not yet been described...

Brain mapping as a tool to study neurodegeneration

Liana G ApostolovaDepartment of Neurology and Laboratory of NeuroImaging, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90095, USANeurotherapeutics 4:387-400. 2007

..Applications to AD and other dementias are discussed, with a brief review of related findings in other neurological and neuropsychiatric illnesses, including epilepsy, HIV/AIDS, schizophrenia, and disorders of brain development...

..Forty subjects were sufficient to discriminate AD from normal and correlate atrophy with CDR scores; 104, 200, and 304 subjects, respectively, were required to correlate MMSE with atrophy, to distinguish MCI from normal, and MCI from AD...

..Finally, we indicate which computational methods are powerful enough to track dementia in clinical trials, on the basis of their efficiency and sensitivity to early change, and the detail in the measures they provide...

..We describe biochemical, imaging, and neuropathological changes in a pedigree with a novel PSEN1 mutation. This allows us to validate the pathogenicity of this mutation and the indices used to assess AD...