Previous GeneCards Identifiers for PDXP Gene

Summaries for PDXP Gene

Entrez Gene Summary for PDXP Gene

Pyridoxal 5-prime-phosphate (PLP) is the active form of vitamin B6 that acts as a coenzyme in maintaining biochemical homeostasis. The preferred degradation route from PLP to 4-pyridoxic acid involves the dephosphorylation of PLP by PDXP (Jang et al., 2003 [PubMed 14522954]).[supplied by OMIM, Mar 2008]

GeneCards Summary for PDXP Gene

PDXP (Pyridoxal (Pyridoxine, Vitamin B6) Phosphatase) is a Protein Coding gene.
Diseases associated with PDXP include laurence-moon syndrome.
Among its related pathways are Cytoskeletal Signaling and Metabolism.
GO annotations related to this gene include phosphoprotein phosphatase activity and phosphoserine phosphatase activity.
An important paralog of this gene is PGP.

mRNA Expression by UniProt/SwissProt for PDXP Gene

Tissue specificity:Ubiquitous. Highly expressed in all the regions of central nerve system except the spinal cord. Also expressed at high level in liver and testis. In fetus, it is weakly expressed in all organs except brain.