The subject of the postdoc position will be designing new experiments to get as much information as we can on how pharmaceutical compounds bind to ion channels and affect the currents that flow through them. As part of this I would like to explore how to characterise and quantify model discrepancy, and design experiments for that, as well as model selection and parameterisation of the models.

We’ll then use the data generated by these experiments to build models of pharmaceutical drug interactions with ion currents, working with partners in pharmaceutical companies and international regulators to test out these new models. The project will involve learning some of the modelling behind electrophysiology and pharmacology, as well as data science/statistics behind designing experiments and choosing models and parameters. It will build on some of our recent work on novel experimental design, some of which is available in a preprint here.