Cho started at WABC-TV on July 6, 2003, replacing Diana Williams at 6 p.m. and 11 p.m.[1] In 2011, Cho began anchoring the station's new "First at 4:00" newscast,[citation needed] with David Novarro, filling the hour left vacant by the departure of The Oprah Winfrey Show. In addition, as of 2012, she continues to anchor the 6 p.m. broadcasts with Bill Ritter.[1]

In 2003, Cho was listed as one of People magazine's "50 Most Beautiful People".[6] She and husband Evan Gottlieb had daughter Louisa Simone Gottlieb on May 17, 2007, in New York City.[7] She was scheduled to return to work on September 4, 2007.[8]