The authors showed that caudal vein of the embryonic zebrafish can be used as a model for assessing nanoparticle interactions with mammalian liver sinusoidal endothelial cells and macrophages. [ACS Nano]
Abstract

Researchers showed that cavin-1, a component of caveolae, is a functionally significant suppressor of cytokine signaling 3 (SOCS3)-interacting protein. SOCS3 was critical for cavin-1 stabilization, such that deletion of SOCS3 reduced the expression of cavin-1 and caveolin-1 proteins, thereby reducing caveola abundance in endothelial cells. [Nat Commun]
Full Article

Investigators demonstrated the considerable remodeling potential of spinal cord blood vessels and highlighted an important angiogenic role for the α5β1 integrin in promoting endothelial proliferation. [Angiogenesis]
Abstract

Angiopoietin-1 and angiopoietin-2 inhibited the thrombin/thrombomodulin (TM)-mediated generation of activated protein C and thrombin-activatable fibrinolysis inhibitor in cultured endothelial cells, and inhibited the binding of thrombin to TM in vitro. [Sci Rep]
Full Article

Investigators developed axeno-free supplement for cell culture-based formulation for 2D-culture of outgrowth endothelial cells (OEC), and then used it for generating co-culture spheroids of OEC and mesenchymal stem cells. [Sci Rep]
Full Article

Given quercetin’s narrow therapeutic index reported in work done with human umbilical vein endothelial cells (HUVECs), the authors hypothesized that quercetin is not innocuous for non-senescent adult human vascular endothelial cells at concentrations that have been reported to be safe for proliferating HUVECs. [PLoS One]
Full Article

Scientists showed that thymic endothelial cells (ECs) comprise a critical pathway of regeneration via their production of bone morphogenetic protein 4 (BMP4). ECs increased their production of BMP4 after thymic damage, and abrogating BMP4 signaling or production by either pharmacologic or genetic inhibition impaired thymic repair. [Sci Immunol]
Full Article

After a months-long standoff, a consortium of hundreds of South Korean universities has reached a new deal with scientific publisher Elsevier for access to ScienceDirect, a database containing content from 3,500 academic journals and thousands of electronic books. [ScienceInsider]
Editorial

The United Kingdom has gained a new science minister as part of a broader reshuffle of government posts. Sam Gyimah, who moves from the Ministry of Justice, was appointed minister for universities and science, replacing Jo Johnson. [Nature News]
Editorial