Alternative Names

Causes

Brachial plexus dysfunction (brachial plexopathy) is a form of peripheral neuropathy. It occurs when there is damage to the brachial plexus, an area where a nerve bundle from the spinal cord splits into the individual arm nerves.

Damage to the brachial plexus is usually related to direct injury to the nerve, stretching injuries, pressure from tumors in the area, or damage that results from radiation therapy.

Brachial plexus dysfunction may also be associated with:

Birth defects that put pressure on the neck area

Exposure to toxins, chemicals, or drugs

Inflammatory conditions, such as those due to a virus or immune system problem

In some cases, no cause can be identified.

Symptoms

Horner syndrome - possibly caused by a lung tumor that presses on the nerve

Exams and Tests

Age and gender are important because some plexus problems are more common in certain groups (for example, young men more often have inflammatory brachial plexus disease).

A neuromuscular examination of the arm, hand, and wrist will show a problem with the nerves of the brachial plexus. Arm reflexes may be abnormal. Specific muscle problems may indicate which portion of the brachial plexus has been damaged.

Deformities may develop in the arm or hand, and there may be profound loss of muscle mass (atrophy).

Treatment

In some cases, no treatment is required and recovery happens on its own.

If there is no history of injury to the area, then medication, braces or splints, and physical therapy may be recommended. Potent anti-inflammatory drugs (steroids) may be recommended for cases that are caused by inflammatory problems, such as brachial amyotrophy and brachial neuritis.

Surgery may be needed if the disorder is long-lasting, symptoms get worse, or there are severe movement problems or signs of nerve fiber loss. Surgical decompression (removal of structures that press on the nerve) may help some people.

Painkillers such as acetaminophen, aspirin, and ibuprofen may not help control nerve pain (neuralgia). Other medications may be used to reduce stabbing pains, including anti-seizure medications such as phenytoin, carbamazepine, and gabapentin. Tricyclic antidepressants, such as amitriptyline, may also provide pain relief. If pain is severe, a pain specialist should be consulted in order to make sure all options for pain treatment are considered.

Outlook (Prognosis)

The likely outcome depends on the cause. Recovery takes several months and may be incomplete. Nerve pain may be quite uncomfortable and may persist for a long time.

Possible Complications

Deformity of the hand or arm, mild to severe, which can lead to contractures

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