The purpose of this study was to prepare, characterize and evaluate the dissolution behavior of inclusion complexes of furosemide with β-cyclodextrin (β-CD) and hydroxypropyl-β-cyclodextrin (HP-β-CD). Solid complexes of furosemide with β-CD and-HP-β-CD were prepared by using a freeze-drying method. Physical mixtures were prepared for comparison. The inclusion complexes were characterized by differential scanning calorimetry (DSC), Infrared (IR) and dissolution test. “In vitro” dissolutions assays were performed at pH 1,2; pH 4,5 and pH 6,8 media for a 60 min period. Statistical analysis employing ANOVA and Tukey’s Test, for the dissolution efficiency values (ED%), showed that complexation of furosemide with both cyclodextrins improved significantly ED% of the drug in all tested media, suggesting a minor pH influence on dissolution properties of the drug.

Información general

Fecha de exposición:2008

Idioma del documento:Portugués

Revista:Latin American Journal of Pharmacy; vol. 27, no. 4

Institución de origen:Colegio de Farmacéuticos de la Provincia de Buenos Aires