The writer’s preferred lunch on working days is spicy yogurt combined with one of the above dals (lentils).

The tuna-tiki recipe given above can be modified by replacing tuna with chicken, turkey, lamb, and beef in minced forms. Experiment with them and send me your modified recipes you like best at aliacademy7@gmail.com or aliacademy777@yahoo.com with permission to share with other readers.

Textbook of Integrative Medicine

For professional and advanced readers, I present information about health sciences in detail in the twelve volumes of my “The Principles and practice of Integrative Medicine.”

What Is Empirical Healing?

Majid Ali, M.D. All healing is energy healing. Since humans began to look for ways to deal with illness, it sought therapies that worked and were safe. In earlier times, safe and effective therapies were not discarded ju…

Dr. Ali’s Insulin Library

Majid Ali, M.D. My Oxygen Thinking Has Given Me Insights About the Roles of Insulin in Health and Disease which Robustly Challenge the Prevailing Notions of Insulin, Insulin Resistance, and Hyperinsulinism. Large Clai…

Insulin Essentials

Majid Ali, M.D. Very little of What I Learned About Diabetes In Medical School Has Been Validated by My Patients, My True Teachers. Insulin Essentials Insulin is the master energy hormone of the body, for energy genera…

Majid Ali, M.D. Alzheimer’s Disease Before the Supreme Court of Science – 2017 Alzheimer’s Before the Supreme Court of Science – 2017 I have subscribed and read the journal Nature over 25 for years. It is a journal o…

Three Stages of Diabetes

Majid Ali, M.D. Do You Know Which One of the Three Stages of Diabetes You Are In? Why That Is Important? You can Learn This Only With Blood Insulin Test. Diabetes In Hyperinsulinism Stage With High Blood In…

Majid Ali, M.D. Insulin and Glucose Profiles of Reversing Diabetes D3 Series The blood A1c test is an excellent test for monitoring the results of diabetes treatment, but it is not reliable for screening for diabetes…

A Component of Holistic and Integrated Science and Philosophy of Reversing Diabetes

The Golden Begin-Low Build-Slow Principle

Do Not Take All Items In These Guidelines On the first day.

In all guidelines for preserving health and reversing chronic disease with natural remedies, I strongly suggest that readers to consider my Golden Start-Low-Build-Slow Principle. Simply stated, this principle requires that an individual, in trying natural remedies, be cautious and closely observe how the body responds to natural remedies, beginning with small amounts or portions (as low as one-tenth the value on the first day, and doubling them every day until the recommended amount is reached.) If any negative senses are experienced, the item should be discontinued for several days or be taken in smaller amounts for longer periods of time to increase tolerance. It is important that a doctor be consulted to rule out the presence of serious coexisting or underlying conditions.

Family healing work, first and foremost, has to be fun, each member moving on a personal pace. Pushing and brow-beating does not work in the long run, learning and knowing does. Long-term results require a philosophy of love and healing. So, again we celebrate small successes and not sweat missteps.

Reversing Diabetes – Lesson One Includes the Following:

Diabetes is not a sugar problem

Two examples of healthy insulin and glucose (sugar) profiles

One example of insulin and glucose profiles of an individual with diabetes, before and after diabetes reversal

What is insulin intelligence?

Metabolic Actions of Insulin Hormone

How does insulin toxicity (hyperinsulinism) develop)?

Oxygen Model of Insulin Toxicity

Five-Step Plan for Reversing Diabetes

A plan of food choices to prevent sugar spikes that trigger insulin spikes;

A plan to do daily gentle bowel and liver detox;

A program of oxygen-stabilizing spices, herbs, and nutrients;

A program of non-competitive Limbic Exercise; and

A personal goal of self-compassion

Guidelines for Special Remedies for Reversing Diabetes.

Please Do Not Take Every Item on the First Day.

Any item not tolerated well should be withheld for three weeks and tried again.

Posts about 3D Insulin Protocol written by Majid Ali MD. … Diabetes is a two-faced disease, one withinsulin toxicity and the other with insulin depletion: this diabetes duality in itself is most revealing. ….. https://vimeo.com › Majid Ali › Videos.

Majid Ali, M.D. … For individuals with pre-diabetes with insulin toxicity but without high blood sugar levels, my … I present this subject at length in my book entitled “Dr. Ali’s Plan for Reversing Diabetes” and in a 40-minute video seminar that can …

Anti-Inflammatory Foods

Specific Remedies

Chromium, vanadyl, neem leaves, and others.

My First Encounter With the Diabetes-Infection Axis

One of my sharpest recollection of events in a medical clinic in 1961 is of how a professor diagnosed diabetes by looking at the neck of a new patient. The patients had a carbuncle of the neck which is considered diagnostic of diabetes because the disease does not allow to let this skin infection heal. That experience returns whenever I think of the diabetes-infection axis.

Four Historical Footnotes

1876 . W. Epstein controls sugar leak in diabetes with aspirin.

Berliner Klinicsche 1876;3:337-340.

1901. R. Williamson control sugar in urine in diabetes with aspirin.

British Medical Journal. 1901;1:760-762.

1957. Reid J. Macdougall AL Stop insulin injections with aspirin.

British Medical Journal. 1957;8:418-428.

1921. Insulin discovered by the Canadian physician Frederick Banting

and Student Charles H. Best.

Types of Infections

Acute . Viral, Bacterial, yeast, parasitic

Subacute . Viral, Bacterial, yeast, parasitic

Chronic . Viral, Bacterial, yeast, parasitic

Two important microbial species causing infections in diabetes ate Staph aureus and Candida species.

7. Compromised complement system defense molecules

Acute Infections and Chronic Infections

Preferred Natural Remedies

Optimal hydration

Dr. Ali’s Spicy Smoothie

Probiotics (yogurt, Kiefer, Acidophillus)

Turmeric and Vitamin C (1000 mg of each) four times a day

Oregano oil

Special Nutrients (Zinc lozenges, Magnesium, Potassium, Taurine)

Antibiotics, If really needed

Antifungal Spices, Herbs, and Medications.

One of my sharpest recollection is of a patient that I saw as a student in 1961. He came to a medical clinic with a carbuncle (deep seated chronic skin infection) on the back of the neck. My professor took one look at the carbuncle and clinically diagnosed diabetes, which proved right on blood tests. It would be 54 years before I learned the about the following three publications clearly establishing the insulin-inflammation connections.

Three Neglected Insulin Lessons From the Past.

1876 . W. Epstein controls sugar leak in diabetes with aspirin.

Berliner Klinicsche 1876;3:337-340.

R. Williamson control sugar in urine in diabetes with aspirin.

British Medical Journal. 1901;1:760-762.

Reid J. Macdougall AL Stop insulin injections with aspirin.

British Medical Journal. 1957;8:418-428.

I anticipate three questions here: (1) the above three reports refer to Type 2 diabetes (T2D), why do is call them “three insulin lessons”? (2) what lights do the insulin-inflammation connections shed on neurodevelopmental biology? and (3) specifically, what clinical imperatives might be recognized to restore neuronal progenitor cell progression to mature “speech neurons, as well as other neurons involved involved with the autism spectrum, dysautonomia, and related neurodevelopemental disorders? Here are briefanswers: (1) hyperinulinism predates T2D in all cases and maternal hyperinsulinism is a hazard for neuronal progenitor cell progression of the unborn child; (2) unrecognized hyperinsulinism in ASD and CID during prenatal to threatens poses serious threats to developmental biology.

A Crucial Question

Why did I dig them out for investigations into the molecular basis of neurodevelopmental studies discussing the results o I bring The answers: (1) unrecognized maternal hyperinsulinism is a hazard for neurobioilogy of the unborn baby; (2) unrecognized hyperinsulinism in early postnatal life is a hazard for progenitor cell progression; and (3) for neurobioilogy of the unborn baby rain; T2D, is first and foremost, an insulin toxicity problem. Hyperinsulinism predates T2D. This relationship has been recognized for decades. The author has never seen T2D develop without hyperinsulinism preceding it. I have published many case studies toType 2 to illustrate these observayions.

Proinflammatory Cytokines Induced Insulin Resistance

In 1993, 117 years after the first published report of antidiabetes effects of aspirin, the effects of aspirin, the proinflammatory cytokine NFK-a was shown to induce insulin resistance.25,27 This seminal advance led to rapid recognition of similar anti-insulin, pro-diabetes effects of other inflammatory cytokines, adipokines (leptin, adiponectin, and others produced by fat cells), resistin, visfatin, PAI-1, IL-6, angiotensinogen, retinol-binding protein-4, serum amyloid A (SAA), and others.28-33

Insulin Adjudicates Physiological and Pathological Inflammation

The Gut-Diabetes Connection

Throat

Esophagus

Stomach

Small intestine

Large intestine

Digestion starts within the mouth by the action of the enzymes in saliva. It then takes full effect within the stomach and some nutrients are also absorbed into the bloodstream here. Partially digested food known as chyme then undergoes further digestion mainly in the first part of the small intestine known as the duodenum. The small intestine, or small bowel, is the longest part of the gut and gradually the food is completely digested and almost all the nutrients are absorbed into the bloodstream.

4. Sluggish movements of immune cells

5. Increased apoptosis (planned cell suicide)

6. Low levels of inflammatory cytokines

7. Compromised complement system defense molecules

Decreased mobilization of polymorphonuclear leukocytes, chemotaxis, and phagocytic activity may occur during hyperglycemia.[4,9,10] The hyperglycemic environment also blocks the antimicrobial function by inhibiting glucose-6-phosphate dehydrogenase (G6PD), increasing apoptosis of polymorphonuclear leukocytes, and reducing polymorphonuclear leukocyte transmigration through the endothelium.[4] In tWeak

s

4. Complement

Complement

The complement system is one of the main mechanisms responsible for the humoral immunity. It consists of serum and surface proteins whose main functions are to promote the opsonization and phagocytosis of microorganisms through macrophages and neutrophils and to induce the lysis of these microorganisms. Moreover, complement activation products provide the second signal for B-lymphocyte activation and antibody production.

Although some studies have detected a deficiency of the C4 component in DM,[5,6] this reduction of C4 is probably associated with polymorphonuclear dysfunction and reduced cytokine response.[2,5]

Inflammatory cytokines

Mononuclear cells and monocytes of persons with DM secrete less interleukin-1 (IL-1) and IL-6 in response to stimulation by lipopolysaccharides.[2,4] It appears that the low production of interleukins is a consequence of an intrinsic defect in the cells of individuals with DM.[2,7] However, other studies reported that the increased glycation could inhibit the production of IL-10 by myeloid cells, as well as that of interferon gamma (IFN-γ) and tumor necrosis factor (TNF)-α by T cells. Glycation would also reduce the expression of class I major histocompatibility complex (MHC) on the surface of myeloid cells, impairing cell immunity.[8]

Polymorphonuclear and mononuclear leukocytes

Decreased mobilization of polymorphonuclear leukocytes, chemotaxis, and phagocytic activity may occur during hyperglycemia.[4,9,10] The hyperglycemic environment also blocks the antimicrobial function by inhibiting glucose-6-phosphate dehydrogenase (G6PD), increasing apoptosis of polymorphonuclear leukocytes, and reducing polymorphonuclear leukocyte transmigration through the endothelium.[4] In tissues that do not need insulin for glucose transport, the hyperglycemic environment increases intracellular glucose levels, which are then metabolized, using NADPH as a cofactor. The decrease in the levels of NADPH prevents the regeneration of molecules that play a key role in antioxidant mechanisms of the cell, thereby increasing the susceptibility to oxidative stress.

Regarding the mononuclear lymphocytes, some studies had demonstrated that when the glycated hemoglobin (HbA1c) is <8.0%, the proliferative function of CD4 T lymphocytes and their response to antigens is not impaired.[4]

Antibodies

Glycation of immunoglobulin occurs in patients with diabetes in proportion with the increase in HbA1c, and this may harm the biological function of the antibodies.[4] However, the clinical relevance of these observations is not clear, since the response of antibodies after vaccination and to common infections is adequate in persons with DM.[4]

A Component of Holistic and Integrated Science and Philosophy of Reversing Diabetes

The Golden Begin-Low Build-Slow Principle

Do Not Take All Items In These Guidelines On the first day.

In all guidelines for preserving health and reversing chronic disease with natural remedies, I strongly suggest that readers to consider my Golden Start-Low-Build-Slow Principle. Simply stated, this principle requires that an individual, in trying natural remedies, be cautious and closely observe how the body responds to natural remedies, beginning with small amounts or portions (as low as one-tenth the value on the first day, and doubling them every day until the recommended amount is reached.) If any negative senses are experienced, the item should be discontinued for several days or be taken in smaller amounts for longer periods of time to increase tolerance. It is important that a doctor be consulted to rule out the presence of serious coexisting or underlying conditions.

Family healing work, first and foremost, has to be fun, each member moving on a personal pace. Pushing and brow-beating does not work in the long run, learning and knowing does. Long-term results require a philosophy of love and healing. So, again we celebrate small successes and not sweat missteps.

Reversing Diabetes – Lesson One Includes the Following:

Diabetes is not a sugar problem

Two examples of healthy insulin and glucose (sugar) profiles

One example of insulin and glucose profiles of an individual with diabetes, before and after diabetes reversal

What is insulin intelligence?

Metabolic Actions of Insulin Hormone

How does insulin toxicity (hyperinsulinism) develop)?

Oxygen Model of Insulin Toxicity

Five-Step Plan for Reversing Diabetes

A plan of food choices to prevent sugar spikes that trigger insulin spikes;

A plan to do daily gentle bowel and liver detox;

A program of oxygen-stabilizing spices, herbs, and nutrients;

A program of non-competitive Limbic Exercise; and

A personal goal of self-compassion

Guidelines for Special Remedies for Reversing Diabetes.

Please Do Not Take Every Item on the First Day.

Any item not tolerated well should be withheld for three weeks and tried again.

Many patients tell me they missed their breakfast because they were not hungry. I explain that was so because their metabolic rhythm has been disrupted. Rising at 7 am following a dinner at 8 pm the evening before, of course, means a fasting of 11 hours. Fasting means hypoglycemia and acidosis. Extending that period for another two or three or more hours essentially sets a person up for major hypoglycemic-hyperglycemic shifts that trigger insulin and adrenergic roller coasters. In individuals with neurotransmitter volatility — persons with predisposition for anxiety, sadness, or depression — extension of fasting can trigger any or all of those symptoms. For others without such vulnerability, it is really a matter of time until they also succumb to undue tiredness or mood difficulties caused by glucose-insulin-adrenaline-neurotransmitter shifts.

What Is Insulin?

It is a hormone produced by pancreas, a gland located behind the stomach which lowers the blood glucose level by driving glucose into the cells.

Text from the book for the Crank and Crank Shaft Model:The cell membranes become resistant to insulin when they become chemicalized—plasticized, so to speak—and hardened, immobilizing the insulin receptors embedded in the membranes. The insulin receptor is a protein that criss-crosses the cell membrane like a cord. One of the consequences of grease buildup on cell membranes is that insulin receptor becomes turned and twisted, literally and figuratively. In a previous paper, I offered the analogy of a crank and a crank-shaft to explain insulin resistance. I visualize insulin as a crank—a device that transmits rotary motion—and the insulin receptor protein as a crank-shaft embedded in the cell membrane.receptor protein as a crank-shaft embedded in the cell membranes.

Or, the Insulin Lock and Insulin Key Model of Insulin Toxicity, if you so prefer.

Is hyperinsulinism the same state as insulin toxicity?

Yes. I coin the term insulin toxicity to replace hyperinsulinism because it tells the story well, while most people do not know what blood insulin level does hyperinsulinism begin.

How Do I Live Insulin-Healthy Life?

How Do I Become Insulin-wise and Live a Healthy Life?

Read, read, and read about insulin, health, and healing until you love reading about it.

Some Crucial Questions

* How much time do you spend talking about insulin with your patients?

* For chronic ailments, I talk about oxygen and insulin, and then about the bowel and the liver.

* How about spirituality?

As soon as I think the patients is ready for it. Spiritual openness is what matters most, but most patients want to talk about their diseases first.

* You say diabetes is an insulin problem, not and a sugar problem. What do you really mean by this?

Diabetes is not a sugar problem

Two examples of healthy insulin and glucose (sugar) profiles

One example of insulin and glucose profiles of an individual with diabetes, before and after diabetes reversal

What is insulin intelligence

Metabolic Actions of Insulin Hormone

How does insulin toxicity (hyperinsulinism) develop)?

Oxygen Model of Insulin Toxicity

WELCOME!

Why Is It Important Not to Consider Diabetes to Be a Sugar Problem?

Diabetes is not a sugar problem. Diabetes can neither be prevented nor reversed by focusing on blood glucose (sugar) levels. To reverse diabetes, we need “Insulin Intelligence,”which requires the study of the subject with healing literacy, not with disease literacy or drug literacy. Please study Table 3 for the insulin and glucose profiles of the man who reversed diabetes by making his insulin work. Closely examine his falling insulin level accompanied by his falling blood glucose levels with passing months. But first for comparison study, I offer two ideal insulin profiles presented in Tables 1 and 2.

What Is A1c Test?

It is a blood test which indicates the average of blood glucose levels for about 90 days before the blood sample is drawn.

In my experience, A1c test is not reliable for screening for diabetes, nor for insulin toxicity. It is a good test for knowing how effective the treatment for diabetes and/or insulin toxicity is.

An A1c value of 5.5% indicated excellent blood glucose levels. A value of 6 means poor control of diabetes. A value of 6.5 means very poor control A value of ten means an urgent need for improved treatment. I consider values of 12 and over to indicate medical emergencies.

WELCOME!

Is Fasting Blood Glucose Level a Good Screening Test for diabetes?

No. I have seen this test to unreliable in too many cases. I have seen patient with diabetes show a fasting blood glucose level of less than 95, which is considered negative for the disease. I have also seen patient who had fasting glucoe level of over 100 who did not have diabetes when a full 3-hour test was done.

At What Blood Glucose Level Is Diabetes Diagnosed?

When the blood glucose level is 200 or over in the 2-hr blood sample drawn following a test load of 75 grams of glucose taken by mouth (as a syrup.

At What Blood Glucose Level Is Prediabetes Diagnosed?

When the blood glucose level is 200 or over in the 1-hr blood sample drawn following a test load of 75 grams of glucose taken by mouth (as a syrup.

The Seed-Feed-and-Occasionally-Weed-Way to Reverse Chronic Inflammatory, Immune, and Infectious Diseases

Seeding is the repopulation of the gut with microflora that have been destroyed by indiscriminate use of antibiotics or crowded out by the unrestrained proliferation of yeast and bacterial organisms such as the Proteus and Pseudomonas species. The “guardian angel bacteria” for bowel ecology belong to the Bifidobacterium and Lactobacillus species. Some other species also play protective roles. In health, these organisms provide the necessary counterbalance to the growth of yeast and pathogenic bacterial organisms. Beyond this, these organisms produce several molecules that play critical roles in our molecular defense systems.

Feeding is the use of some growth factors that the normal bowel flora require to flourish. These include biotin, pantetheine, Vitamin B12 and others. We clinicians have used Vitamin B12 for decades with good clinical results (to the great chagrin of those “academicians” who considered it quackery because they couldn’t understand how this vitamin could ever help anybody except those with pernicious anemia). One of the principal mechanisms by which vitamin B12 exerts its myriad beneficial effects is by serving as a “growth hormone” for health-preserving bowel flora. Of course, this vitamin has several other essential roles. It plays a role in the citric acid cycle (the main molecular pathway for energy generation where it facilitates the conversion of methylmalonyl-CoA to succinyl-CoA) and is essential for cell maturation. Further, Vitamin B12 benefits many patients with neuropsychiatric disorders unassociated with anemia or macrocytosis (N Eng J Med 318:1720; 1988).

Occasional weeding is the use of several natural substances that are known to suppress the overgrowth of pathogenic bacteria, viruses and yeasts. During initial treatment, I frequently use oral nystatin or fluoconazole (Diflucan) for short periods of two to three weeks, partly for diagnostic and partly for therapeutic reasons (how a person with one of the ABE states responds to these agents is useful in assessing the degree of damage to bowel ecology). Extensive clinical experience has convinced me that long-term clinical results are far superior when the use of drugs is kept to a minimum.

In my book entitled “Dr. Ali’s Plan for Reversing Diabetes,” I illustrated the insulin/insulin receptor dysfunction with a crank/crank-shaft analogy. Below is some text from that book (available at http://www.majidali.com). The cell membranes become resistant to insulin when they become chemicalized—plasticized, so to speak—and hardened, immobilizing the insulin receptors embedded in the membranes. The insulin receptor is a protein that criss-crosses the cell membrane like a cord. One of the consequences of grease buildup on cell membranes is that insulin receptor becomes turned and twisted, literally and figuratively. In a previous paper, I offered the analogy of a crank and a crank-shaft to explain insulin resistance. I visualize insulin as a crank—a device that transmits rotary motion—and the insulin receptor protein as a crank-shaft embedded in the cell membrane.receptor protein as a crank-shaft embedded in the cell membranes.

WELCOME! Metabolic Actions of Insulin Hormone

Insulin hormone preserves health in many ways. Specifically, it has metabolic, vascular, and signaling roles, including:

☞ Facilitation of the entry of glucose in cells;

☞ The breakdown of glucose to produce energy in cells;

☞ Storage of glucose in the liver;

☞ Conversion of glucose into fatty acids;

☞ Activation of specific enzymes involved with protein metabolism; and

☞ Changes in vascular reactivity (compliance).

Insulin-Wise Living With Insulin Intelligence ELCOME!

I introduce term Insulin Intelligence for a clear working understanding of molecular biology of insulin which is necessary for preventing and reversing diabetes of all types. Specifically, it includes a deep knowledge of energetic, metabolic, signaling and other functions of insulin. To foster Insulin Intelligence, I include in this article brief outlines of Oxygen Model of Insulin Toxicity and The Crank-Crank-Shaft Model of Insulin Dysfunction. Before that, below in the simplest possible words, I offer the core of my dietary guidelines for normalizing insulin homeostasis.

Insulin-Wise Eating

Five Things to Remember

Sugar in any form increases insulin toxicity

Healthy fats are insulin-friendly.

Healthy proteins are insulin-friendly.

All carbohydrates in excess are insulin unfriendly.

Vegetables are insulin-friendly.

Insulin in excess (insulin toxicity) is fattening and inflaming.

W Oxygen Models of Insulin Toxicity and Diabetes Type 2

I proposed my Oxygen Models of Insulin Toxicity and Diabetes as unifying models that recognize disturbances of oxygen functions as the fundamental commonality of all elements that cause dysfunctional insulin signaling, hyperinsulinism (excess insulin), insulin resistance (inability of the insulin receptor to respond to insulin), and the biochemical and clinical consequences of insulin dysfunction.

Models in medicine are tested, validated, or refuted with ongoing scientific observation. In clinical medicine, I add a fourth criterion for a model’s validity: it must facilitate health and healing. How does my Oxygen Model of Insulin Toxicity stand up to these criteria? I leave that to the readers’ faculty of considering the evidence which I present in a large series of my articles on http/:VUIM.org and in my insulin channels on my YouTube Science, Health, and Healing Encyclopedia.

One example of insulin and glucose profiles of an individual with diabetes, before and after diabetes reversal

What is insulin intelligence

Metabolic Actions of Insulin Hormone

How does insulin toxicity (hyperinsulinism) develop)?

Oxygen Model of Insulin Toxicity

Diabetes Is Not A Sugar Problem

Diabetes is not a sugar problem. Diabetes can neither be prevented nor reversed by focusing on blood glucose (sugar) levels. To reverse diabetes, we need “Insulin Intelligence,”which requires the study of the subject with healing literacy, not with disease literacy or drug literacy. Please study Table 3 for the insulin and glucose profiles of the man who reversed diabetes by making his insulin work. Closely examine his falling insulin level accompanied by his falling blood glucose levels with passing months. But first for comparison study, I offer two ideal insulin profiles presented in Tables 1 and 2.

In my book entitled “Dr. Ali’s Plan for Reversing Diabetes,” I illustrated the insulin/insulin receptor dysfunction with a crank/crank-shaft analogy. Below is some text from that book (available at http://www.majidali.com). The cell membranes become resistant to insulin when they become chemicalized—plasticized, so to speak—and hardened, immobilizing the insulin receptors embedded in the membranes. The insulin receptor is a protein that criss-crosses the cell membrane like a cord. One of the consequences of grease buildup on cell membranes is that insulin receptor becomes turned and twisted, literally and figuratively. In a previous paper, I offered the analogy of a crank and a crank-shaft to explain insulin resistance. I visualize insulin as a crank—a device that transmits rotary motion—and the insulin receptor protein as a crank-shaft embedded in the cell membrane.receptor protein as a crank-shaft embedded in the cell membranes.

Metabolic Actions of Insulin Hormone

Insulin hormone preserves health in many ways. Specifically, it has metabolic, vascular, and signaling roles, including:

☞ Facilitation of the entry of glucose in cells;

☞ The breakdown of glucose to produce energy in cells;

☞ Storage of glucose in the liver;

☞ Conversion of glucose into fatty acids;

☞ Activation of specific enzymes involved with protein metabolism; and

☞ Changes in vascular reactivity (compliance).

What Is Insulin Intelligence?

I introduce term Insulin Intelligence for a clear working understanding of molecular biology of insulin which is necessary for preventing and reversing diabetes of all types. Specifically, it includes a deep knowledge of energetic, metabolic, signaling and other functions of insulin. To foster Insulin Intelligence, I include in this article brief outlines of Oxygen Model of Insulin Toxicity and The Crank-Crank-Shaft Model of Insulin Dysfunction. Before that, below in the simplest possible words, I offer the core of my dietary guidelines for normalizing insulin homeostasis.

Five Things to Remember

Sugar in any form increases insulin toxicity

Healthy fats are insulin-friendly.

Healthy proteins are insulin-friendly.

All carbohydrates in excess are insulin unfriendly.

Vegetables are insulin-friendly.

Insulin in excess (insulin toxicity) is fattening and inflaming.

The Oxygen Models of Insulin Toxicity and Diabetes

I proposed my Oxygen Models of Insulin Toxicity and Diabetes as unifying models that recognize disturbances of oxygen functions as the fundamental commonality of all elements that cause dysfunctional insulin signaling, hyperinsulinism (excess insulin), insulin resistance (inability of the insulin receptor to respond to insulin), and the biochemical and clinical consequences of insulin dysfunction.

Models in medicine are tested, validated, or refuted with ongoing scientific observation. In clinical medicine, I add a fourth criterion for a model’s validity: it must facilitate health and healing. How does my Oxygen Model of Insulin Toxicity stand up to these criteria? I leave that to the readers’ faculty of considering the evidence which I present in a large series of my articles on http/:VUIM.org and in my insulin channels on my YouTube Science, Health, and Healing Encyclopedia.

Dedication

I dedicate this article to Carol, the wife of my patient who completely reversed his diabetes Type 2. I asked him, “What helped you most in reversing your diabetes?” “Understanding insulin. That was the best thing you did for me. You helped me understand relationships of food with insulin,” he replied. “What did she have to do with it?” I asked pointing to his wife. “Everything! Everything!” he replied.

1. Facilitation of entry of glucose into cells.

2. Breakdown of glucose to produce ATP energy.

3. Storage of energy into the liver and muscles.

4. Conversion of glucose into fats and proteins.

5. Serve as a signaling molecule for multiple growth reactions.

How Does Insulin Toxicity Develop?

The Crank-Crank Shift Model of Insulin Toxicity

In my book entitled “Dr. Ali’s Plan for Reversing Diabetes,” I illustrated the insulin/insulin receptor dysfunction with a crank/crank-shaft analogy. Below is some text from that book (available at http://www.majidali.com). The cell membranes become resistant to insulin when they become chemicalized—plasticized, so to speak—and hardened, immobilizing the insulin receptors embedded in the membranes. The insulin receptor is a protein that criss-crosses the cell membrane like a cord. One of the consequences of grease buildup on cell membranes is that insulin receptor becomes turned and twisted, literally and figuratively. In a previous paper, I offered the analogy of a crank and a crank-shaft to explain insulin resistance. I visualize insulin as a crank—a device that transmits rotary motion—and the insulin receptor protein as a crank-shaft embedded in the cell membrane.receptor protein as a crank-shaft embedded in the cell membranes.

Or, the Insulin Lock and Insulin Key Model of Insulin Toxicity, if you so prefer.

Is hyperinsulinism the same state as insulin toxicity?

Yes. I coin the term insulin toxicity to replace hyperinsulinism because it tells the story well, while most people do not know what blood insulin level does hyperinsulinism begin.

How Do I Become Insulin-wise and Live a Healthy Life?

Read, read, and read about insulin, health, and healing until you love reading about it.

Some Crucial Questions

* How much time do you spend talking about insulin with your patients?

* For chronic ailments, I talk about oxygen and insulin, and then about the bowel and the liver.

* How about spirituality?

As soon as I think the patients is ready for it. Spiritual openness is what matters most, but most patients want to talk about their diseases first.

* You say diabetes is an insulin problem, not and a sugar problem. What do you really mean by this?

Diabetes is not a sugar problem

Two examples of healthy insulin and glucose (sugar) profiles

One example of insulin and glucose profiles of an individual with diabetes, before and after diabetes reversal

What is insulin intelligence

Metabolic Actions of Insulin Hormone

How does insulin toxicity (hyperinsulinism) develop)?

Oxygen Model of Insulin Toxicity

Why Is It Important Not to Consider Diabetes to Be a Sugar Problem?

Diabetes is not a sugar problem. Diabetes can neither be prevented nor reversed by focusing on blood glucose (sugar) levels. To reverse diabetes, we need “Insulin Intelligence,”which requires the study of the subject with healing literacy, not with disease literacy or drug literacy. Please study Table 3 for the insulin and glucose profiles of the man who reversed diabetes by making his insulin work. Closely examine his falling insulin level accompanied by his falling blood glucose levels with passing months. But first for comparison study, I offer two ideal insulin profiles presented in Tables 1 and 2.

What Is A1c Test?

It is a blood test which indicates the average of blood glucose levels for about 90 days before the blood sample is drawn.

In my experience, A1c test is not reliable for screening for diabetes, nor for insulin toxicity. It is a good test for knowing how effective the treatment for diabetes and/or insulin toxicity is.

An A1c value of 5.5% indicated excellent blood glucose levels. A value of 6 means poor control of diabetes. A value of 6.5 means very poor control A value of ten means an urgent need for improved treatment. I consider values of 12 and over to indicate medical emergencies.

Is Fasting Blood Glucose Level a Good Screening Test for diabetes?

No. I have seen this test to unreliable in too many cases. I have seen patient with diabetes show a fasting blood glucose level of less than 95, which is considered negative for the disease. I have also seen patient who had fasting glucoe level of over 100 who did not have diabetes when a full 3-hour test was done.

At What Blood Glucose Level Is Diabetes Diagnosed?

When the blood glucose level is 200 or over in the 2-hr blood sample drawn following a test load of 75 grams of glucose taken by mouth (as a syrup.

At What Blood Glucose Level Is Prediabetes Diagnosed?

When the blood glucose level is 200 or over in the 1-hr blood sample drawn following a test load of 75 grams of glucose taken by mouth (as a syrup.

The Seed-Feed-and-Occasionally-Weed-Way to Reverse Chronic Inflammatory, Immune, and Infectious Diseases

Seeding is the repopulation of the gut with microflora that have been destroyed by indiscriminate use of antibiotics or crowded out by the unrestrained proliferation of yeast and bacterial organisms such as the Proteus and Pseudomonas species. The “guardian angel bacteria” for bowel ecology belong to the Bifidobacterium and Lactobacillus species. Some other species also play protective roles. In health, these organisms provide the necessary counterbalance to the growth of yeast and pathogenic bacterial organisms. Beyond this, these organisms produce several molecules that play critical roles in our molecular defense systems.

Feeding is the use of some growth factors that the normal bowel flora require to flourish. These include biotin, pantetheine, Vitamin B12 and others. We clinicians have used Vitamin B12 for decades with good clinical results (to the great chagrin of those “academicians” who considered it quackery because they couldn’t understand how this vitamin could ever help anybody except those with pernicious anemia). One of the principal mechanisms by which vitamin B12 exerts its myriad beneficial effects is by serving as a “growth hormone” for health-preserving bowel flora. Of course, this vitamin has several other essential roles. It plays a role in the citric acid cycle (the main molecular pathway for energy generation where it facilitates the conversion of methylmalonyl-CoA to succinyl-CoA) and is essential for cell maturation. Further, Vitamin B12 benefits many patients with neuropsychiatric disorders unassociated with anemia or macrocytosis (N Eng J Med 318:1720; 1988).

Occasional weeding is the use of several natural substances that are known to suppress the overgrowth of pathogenic bacteria, viruses and yeasts. During initial treatment, I frequently use oral nystatin or fluoconazole (Diflucan) for short periods of two to three weeks, partly for diagnostic and partly for therapeutic reasons (how a person with one of the ABE states responds to these agents is useful in assessing the degree of damage to bowel ecology). Extensive clinical experience has convinced me that long-term clinical results are far superior when the use of drugs is kept to a minimum.

In my book entitled “Dr. Ali’s Plan for Reversing Diabetes,” I illustrated the insulin/insulin receptor dysfunction with a crank/crank-shaft analogy. Below is some text from that book (available at http://www.majidali.com). The cell membranes become resistant to insulin when they become chemicalized—plasticized, so to speak—and hardened, immobilizing the insulin receptors embedded in the membranes. The insulin receptor is a protein that criss-crosses the cell membrane like a cord. One of the consequences of grease buildup on cell membranes is that insulin receptor becomes turned and twisted, literally and figuratively. In a previous paper, I offered the analogy of a crank and a crank-shaft to explain insulin resistance. I visualize insulin as a crank—a device that transmits rotary motion—and the insulin receptor protein as a crank-shaft embedded in the cell membrane.receptor protein as a crank-shaft embedded in the cell membranes.

WELCOME! Metabolic Actions of Insulin Hormone

Insulin hormone preserves health in many ways. Specifically, it has metabolic, vascular, and signaling roles, including:

☞ Facilitation of the entry of glucose in cells;

☞ The breakdown of glucose to produce energy in cells;

☞ Storage of glucose in the liver;

☞ Conversion of glucose into fatty acids;

☞ Activation of specific enzymes involved with protein metabolism; and

☞ Changes in vascular reactivity (compliance).

Insulin-Wise Living With Insulin Intelligence ELCOME!

I introduce term Insulin Intelligence for a clear working understanding of molecular biology of insulin which is necessary for preventing and reversing diabetes of all types. Specifically, it includes a deep knowledge of energetic, metabolic, signaling and other functions of insulin. To foster Insulin Intelligence, I include in this article brief outlines of Oxygen Model of Insulin Toxicity and The Crank-Crank-Shaft Model of Insulin Dysfunction. Before that, below in the simplest possible words, I offer the core of my dietary guidelines for normalizing insulin homeostasis.

Insulin-Wise Eating

Five Things to Remember

Sugar in any form increases insulin toxicity

Healthy fats are insulin-friendly.

Healthy proteins are insulin-friendly.

All carbohydrates in excess are insulin unfriendly.

Vegetables are insulin-friendly.

Insulin in excess (insulin toxicity) is fattening and inflaming.

W Oxygen Models of Insulin Toxicity and Diabetes Type 2

I proposed my Oxygen Models of Insulin Toxicity and Diabetes as unifying models that recognize disturbances of oxygen functions as the fundamental commonality of all elements that cause dysfunctional insulin signaling, hyperinsulinism (excess insulin), insulin resistance (inability of the insulin receptor to respond to insulin), and the biochemical and clinical consequences of insulin dysfunction.

Models in medicine are tested, validated, or refuted with ongoing scientific observation. In clinical medicine, I add a fourth criterion for a model’s validity: it must facilitate health and healing. How does my Oxygen Model of Insulin Toxicity stand up to these criteria? I leave that to the readers’ faculty of considering the evidence which I present in a large series of my articles on http/:VUIM.org and in my insulin channels on my YouTube Science, Health, and Healing Encyclopedia.

One example of insulin and glucose profiles of an individual with diabetes, before and after diabetes reversal

What is insulin intelligence

Metabolic Actions of Insulin Hormone

How does insulin toxicity (hyperinsulinism) develop)?

Oxygen Model of Insulin Toxicity

Diabetes Is Not A Sugar Problem

Diabetes is not a sugar problem. Diabetes can neither be prevented nor reversed by focusing on blood glucose (sugar) levels. To reverse diabetes, we need “Insulin Intelligence,”which requires the study of the subject with healing literacy, not with disease literacy or drug literacy. Please study Table 3 for the insulin and glucose profiles of the man who reversed diabetes by making his insulin work. Closely examine his falling insulin level accompanied by his falling blood glucose levels with passing months. But first for comparison study, I offer two ideal insulin profiles presented in Tables 1 and 2.

In my book entitled “Dr. Ali’s Plan for Reversing Diabetes,” I illustrated the insulin/insulin receptor dysfunction with a crank/crank-shaft analogy. Below is some text from that book (available at http://www.majidali.com). The cell membranes become resistant to insulin when they become chemicalized—plasticized, so to speak—and hardened, immobilizing the insulin receptors embedded in the membranes. The insulin receptor is a protein that criss-crosses the cell membrane like a cord. One of the consequences of grease buildup on cell membranes is that insulin receptor becomes turned and twisted, literally and figuratively. In a previous paper, I offered the analogy of a crank and a crank-shaft to explain insulin resistance. I visualize insulin as a crank—a device that transmits rotary motion—and the insulin receptor protein as a crank-shaft embedded in the cell membrane.receptor protein as a crank-shaft embedded in the cell membranes.

Metabolic Actions of Insulin Hormone

Insulin hormone preserves health in many ways. Specifically, it has metabolic, vascular, and signaling roles, including:

☞ Facilitation of the entry of glucose in cells;

☞ The breakdown of glucose to produce energy in cells;

☞ Storage of glucose in the liver;

☞ Conversion of glucose into fatty acids;

☞ Activation of specific enzymes involved with protein metabolism; and

☞ Changes in vascular reactivity (compliance).

What Is Insulin Intelligence?

I introduce term Insulin Intelligence for a clear working understanding of molecular biology of insulin which is necessary for preventing and reversing diabetes of all types. Specifically, it includes a deep knowledge of energetic, metabolic, signaling and other functions of insulin. To foster Insulin Intelligence, I include in this article brief outlines of Oxygen Model of Insulin Toxicity and The Crank-Crank-Shaft Model of Insulin Dysfunction. Before that, below in the simplest possible words, I offer the core of my dietary guidelines for normalizing insulin homeostasis.

Five Things to Remember

Sugar in any form increases insulin toxicity

Healthy fats are insulin-friendly.

Healthy proteins are insulin-friendly.

All carbohydrates in excess are insulin unfriendly.

Vegetables are insulin-friendly.

Insulin in excess (insulin toxicity) is fattening and inflaming.

The Oxygen Models of Insulin Toxicity and Diabetes

I proposed my Oxygen Models of Insulin Toxicity and Diabetes as unifying models that recognize disturbances of oxygen functions as the fundamental commonality of all elements that cause dysfunctional insulin signaling, hyperinsulinism (excess insulin), insulin resistance (inability of the insulin receptor to respond to insulin), and the biochemical and clinical consequences of insulin dysfunction.

Models in medicine are tested, validated, or refuted with ongoing scientific observation. In clinical medicine, I add a fourth criterion for a model’s validity: it must facilitate health and healing. How does my Oxygen Model of Insulin Toxicity stand up to these criteria? I leave that to the readers’ faculty of considering the evidence which I present in a large series of my articles on http/:VUIM.org and in my insulin channels on my YouTube Science, Health, and Healing Encyclopedia.

A Special Note: I suggest that individuals considering this FREE course scan this outline at least twice the to become familiar with the organization of its three parts, and then decide how to pace themeselves. Search box of this web site will readily take them to the subjects and articles of their interest.

The Course can be completed in six weeks or six months, or on an individual’s own pace.

Course Study Partners

Studying anything with a study partner is always an excellent idea. It especially valuable for this course whether taken for weight loss or diabetes concerns (family history, recent or old diagnosis, recent diagnosis of diabetes-related fatty liver, kidney failure with threat of dialysis, vision problems, cardiovascular disorders, or worries about memory loss and brain shrinking.

Course Study Textbook

Dr. Ali’s Diabetes Reversal Plan

Dr. Ali’s Insulin Toxicity Workbook

Basic Questions

Is diabetes a sugar problem? No.

Is diabetes an insulin toxicity problem? Yes.

Can diabetes be reversed? Yes. Nearly in all cases of Type 2 diabetes in the first three to fives years of diagnosis.

The above answers are unexpected for me. Why is it so? (Please answer this question yourself.)

Diabetes can neither be diagnosed early nor reversed if it is seen as a sugar problem.

Body Organs of Special Interest inOxygen Models of Diabetes and Insulin Toxicity

Gut

Liver

Thalamus in the Brain

Muscles

Pancreas

Why Is the pancreas gland that produces insulin so low in the order of body organs?

I invite readers to keep this question in the mind as they consider Dr. Ali’s Course on Diabetes Reversal.

Scientific Basis of Insulin-Based Diabetes Reversal

Dr. Ali’s Diabetes Course is based on the sciences of:

Molecular Biology of Oxygen

Insulin homeostasis

Study of insulin toxicity defines the problem. Solutions are in the study of oxygen.

☞ Insulin Toxicity (to Know the Problem)

☞ Diabetes Reversal (to Know the Solution)

Five Threats to Humankind:

Developmental Challenges of the Unborn

Diabetes

Dialysis

Dementia

Disability

All five are rooted in insulin toxicity. I anticipate that some readers will roll their eyes on the first item listed above. That only means they are not aware of the frequency with which hyperinsulinism is encountered in children with autism, dysautonomia, OCD, POTS, and related neurodevelopmental challenges faced by children in prenatal and postnatal lives.

Oxygen Models of Insulin Toxicity and Diabetes Reversal Five Threats to Humankind:

Dr. Ali’s Insulin Toxicity Course and Dr. Ali’s Diabetes Reversal Course are based on Oxygen Models of Diabetes and Insulin Toxicity. Simply stated, these models explains all aspects of Type 2 diabetes—causes, clinical course, consequences, and control—on the basis of disturbed oxygen function. A full description of these models is included at the end of this article.

Body Organs of Special Interest inOxygen Models of Diabetes and Insulin Toxicity

Gut

Liver

Thalamus in the Brain

Muscles

Pancreas

Why Is the pancreas gland that produces insulin so low in the order of body organs?

I invite readers to keep this question in the mind as they consider my Course on Diabetes?

The Gut-Diabetes Connection

The Gut-Diabetes Connections

Throat

Esophagus

Stomach

Small intestine

Large intestine

Digestion starts within the mouth by the action of the enzymes in saliva. It then takes full effect within the stomach and some nutrients are also absorbed into the bloodstream here. Partially digested food known as chyme then undergoes further digestion mainly in the first part of the small intestine known as the duodenum. The small intestine, or small bowel, is the longest part of the gut and gradually the food is completely digested and almost all the nutrients are absorbed into the bloodstream.

The Thalamus-Feeding-Weight-Diabetes Connections

The Quick Facts

Location: Part of the forebrain, below the corpus callosumFunction: Responsible for relaying information from the sensory receptors to proper areas of the brain where it can be processed

The thalamus in the brain has special centers for glucose and regulates some aspects of sensory information that is being transmitted to the brain.

What Is More Important in Diabetes?

In Beta Cells of the pancreas where insulin is produced?

Or in cell membranes where it moves receptor proteins?

muscleWhere Insulin Is Produced Or Where It Is Used?

What Is Insulin? Where Does It Come From?

The pancreas is a long, slender organ, most of which is located posterior to the bottom half of the stomach. Although it is primarily an exocrine gland, secreting a variety of digestive enzymes, the pancreas has an endocrine function. Its pancreatic islets—clusters of cells formerly known as the islets of Langerhans—secrete the hormones glucagon, insulin, somatostatin, and pancreatic polypeptide (PP).

Pancreas

The pancreatic exocrine function involves the acinar cells secreting digestive enzymes that are transported into the small intestine by the pancreatic duct. Its endocrine function involves the secretion of insulin (produced by beta cells) and glucagon

☞ Insulin Toxicity Course (to Know the Problem Well

☞ Diabetes Reversal Course to Know then Solution Well for Reversing Diabetes?

I offer my course in two parts: (1) Dr. Ali’s insulin Toxicity Course; and (2) Dr. Ali’s Diabetes Reversal Course. I attribute the two parts of this course to myself for the simple reason that it makes it easier for people to find it on the internet.

The Oxygen Model of Diabetes provides a simple model that allows physicians to reduce complexities of diverse clinical syndromes into a workable simplicity.

This model predicts that ongoing research will reveal that components of acidosis (excess acidity), oxidosis (increased oxidative stress), and CUD (clotting-unclotting dysequilibrium) will be found to play important roles in the pathology and clinical features of Type 2 diabetes.

The crucial importance of the Unifying Oxygen Model of Type diabetes is that it:

☞ Explains the scientific basis of Type 2 diabetes and its complications;

☞ Sheds light how Type 2 diabetes can be prevented and reversed by addressing all oxygen-related issues;

☞ Elucidates how toxicities of foods, environments, and thoughts cause tissue injury and lead to Type 2 diabetes;

☞ Reveals the mechanisms by which various detox therapies work (Oxygen is the primal detergent which removes cellular grease and allows cells to breathe freely); and

☞ Allows the formulation of rational and effective designs for reversing Type 2 diabetes; and

☞ Provides explanations of mechanisms by which time-honored natural remedies work to control and prevent Type 2 diabetes.

In general, fasting Blood sugar test is relied upon for screening for diabetes. I have seen many cases in which diabetes remained undiagnosed because the fasting blood sugar was below 100 mg/dL. Had a complete three-hour insulin test been done sooner, the diagnosis of diabetes would have been readily made.

Similarly, A1c test is not a reliable test for diagnosis. I have seen this test to also miss diabetes diagnosis. Again, if three-hour insulin test had been done sooner, the diagnosis of diabetes would have been readily made.

Some readers have been dismayed by my statement that diabetes is not a sugar problem.

Below are some questions they have raised. My answers follow the questions.

CHALLENGES

Ali’s is wrong. Everyone in the world knows that diabetes is a sugar problem,” one dissenter complained.

How can Dr. Ali be wrong and all other doctors in the world be wrong on the sugar-diabetes question?” another asked.

Doesn’t he know that blood sugar is high in diabetes? Why would doctors do blood testing if diabetes was not a sugar problem?

Doctors do blood A1c test. Isn’t it a sugar test,” comes another challenge.

RESPONSES

Everyone in the world knows that diabetes is a sugar problem. This not true. Scientists and well-informed doctors know that excess insulin (insulin toxicity) predates diabetes by five, ten, or more years.

All doctors in the world would be wrong on the sugar-diabetes question. No, all doctors would not be wrong. I have never met any doctor who denies the scientific facts that insulin toxicity (hyperinsulinism) predate Type 2 diabetes (the type of diabetes that affects more than 90% of diabetics in the world).

Does Dr. Ali know that blood sugar is high in diabetes? Yes, I know that. But blood sugar begins to rise years after blood insulin levels rise and begin to injure various body organs. I explain my simple point below with a kitchen gas rang” analogy.

Isn’t A1c test a test for blood sugar? Yes, it is, but this test is not a reliable test for screening for diagnosing diabetes. I have seen patients in which A1c is in the normal range and the patients has diabetes, and other patients whose A1c value is higher but a three-hour test for glucose does not sjows evidence of diabetes.

KITCHEN GAS STOVE ANALOGY

Let us suppose that the gas line in the basement of a house leaks for weeks and then one day there is a fire in the kitchen stove and the house burns down. What would we blame for the house fire, the leaking gas line in the basement or the kitchen stove?

The global tide of diabetes cannot be understood and stemmed without knowing the fundamentals of the molecular biology of insulin, a subject that is sadly and regularly neglected in the prevailing model of medicine. I wrote Insulin Toxicity Series to shed light on the various faces of this pandemic.

Seven Faces of insulin toxicity:

☞ The first stage of insulin toxicity is without apparent negative health effects recognized by the person.
☞ The second stage of insulin toxicity is with negative health effects recognized by the person but unknown to the doctor.
☞ The third stage of insulin toxicity is tissue injury (in the liver, kidneys, skin, and other organs) unrecognized by a doctor who is clueless about molecular biology of insulin.
☞ The fourth stage of insulin toxicity is prediabetes without tests to detect insulin waste and damages.
☞ The fifth stage of insulin toxicity is Type 2 diabetes with the use of diabetes drugs that add to the insulin activity, hence its toxicity, with the blessings of the American Diabetic Association).
☞ The sixth stage of insulin toxicity is toxicity created by peaks of insulin caused by insulin injections (the end-stage of insulin depletion which is called insulin-dependent diabetes).
☞ The seventh stage of insulin toxicity is loss of vision and blindness (diabetic retinopathy), dialysis (diabetic nephropathy), and increased risk of heart attacks, strokes, autoimmune diseases, inflammatory disorders, and all degenerative states.

I present evidence for all of the above in other articles in my Insulin Toxicity Series:

The take-home message of this article is: the use of diabetes drugs to lower blood sugar levels without non-drug plans to lower blood insulin levels is feeding the pandemic of insulin toxicity and diabetes. The American Diabetic Association and The New England Journal of Medicine teach doctors to use only drugs to lower blood sugar when what the people really need are programs to de-grease the cell membranes, free up insulin receptor proteins embedded in the membranes, and lower blood insulin levels.

The last article entitled “Insulin Toxicity and Metformin Mindlessness” reveals how many holistic doctors are succumbing to the lure of easy answers with drugs that do not address the real issues.

Why Is the pancreas gland that produces insulin so low in the order of body organs?

I invite readers to keep this question in the mind as they consider Dr. Ali’s Course on Diabetes Reversal.

My Free Diabetes Course Has Two Parts: (1) Part One – Dr. Ali’s Insulin Toxicity Course; and (2) Part Two: Dr. Ali’s Diabetes Reversal Course. The first part of the course concerns the problem and the second part the solution.

Scientific Basis of Insulin-Based Diabetes Reversal

Five Threats to Humankind:

Developmental Challenges of the Unborn

Diabetes

Dialysis

Dementia

Disability

All five are rooted in insulin toxicity. I anticipate that some readers will roll their eyes on the first item listed above. That only means they are not aware of the frequency with which hyperinsulinism is encountered in children with autism, dysautonomia, OCD, POTS, and related neurodevelopmental challenges faced by children in prenatal and postnatal lives.

Oxygen Models of Insulin Toxicity and Diabetes Reversal Five Threats to Humankind:

Dr. Ali’s Insulin Toxicity Course and Dr. Ali’s Diabetes Reversal Course are based on Oxygen Models of Diabetes and Insulin Toxicity. Simply stated, these models explains all aspects of Type 2 diabetes—causes, clinical course, consequences, and control—on the basis of disturbed oxygen function. A full description of these models is included at the end of this article.

Body Organs of Special Interest inOxygen Models of Diabetes and Insulin Toxicity

Gut

Liver

Thalamus in the Brain

Muscles

Pancreas

Why Is the pancreas gland that produces insulin so low in the order of body organs?

I invite readers to keep this question in the mind as they consider my Course on Diabetes?

The Gut-Diabetes Connection

The Gut-Diabetes Connections

Throat

Esophagus

Stomach

Small intestine

Large intestine

Digestion starts within the mouth by the action of the enzymes in saliva. It then takes full effect within the stomach and some nutrients are also absorbed into the bloodstream here. Partially digested food known as chyme then undergoes further digestion mainly in the first part of the small intestine known as the duodenum. The small intestine, or small bowel, is the longest part of the gut and gradually the food is completely digested and almost all the nutrients are absorbed into the bloodstream.

The Thalamus-Feeding-Weight-Diabetes Connections

The Quick Facts

Location: Part of the forebrain, below the corpus callosumFunction: Responsible for relaying information from the sensory receptors to proper areas of the brain where it can be processed

The thalamus in the brain has special centers for glucose and regulates some aspects of sensory information that is being transmitted to the brain.

What Is More Important in Diabetes?

In Beta Cells of the pancreas where insulin is produced?

Or in cell membranes where it moves receptor proteins?

muscleWhere Insulin Is Produced Or Where It Is Used?

What Is Insulin? Where Does It Come From?

The pancreas is a long, slender organ, most of which is located posterior to the bottom half of the stomach. Although it is primarily an exocrine gland, secreting a variety of digestive enzymes, the pancreas has an endocrine function. Its pancreatic islets—clusters of cells formerly known as the islets of Langerhans—secrete the hormones glucagon, insulin, somatostatin, and pancreatic polypeptide (PP).

Pancreas

The pancreatic exocrine function involves the acinar cells secreting digestive enzymes that are transported into the small intestine by the pancreatic duct. Its endocrine function involves the secretion of insulin (produced by beta cells) and glucagon

☞ Insulin Toxicity Course (to Know the Problem Well

☞ Diabetes Reversal Course to Know then Solution Well for Reversing Diabetes?

I offer my course in two parts: (1) Dr. Ali’s insulin Toxicity Course; and (2) Dr. Ali’s Diabetes Reversal Course. I attribute the two parts of this course to myself for the simple reason that it makes it easier for people to find it on the internet.

The Oxygen Model of Diabetes provides a simple model that allows physicians to reduce complexities of diverse clinical syndromes into a workable simplicity.

This model predicts that ongoing research will reveal that components of acidosis (excess acidity), oxidosis (increased oxidative stress), and CUD (clotting-unclotting dysequilibrium) will be found to play important roles in the pathology and clinical features of Type 2 diabetes.

The crucial importance of the Unifying Oxygen Model of Type diabetes is that it:

☞ Explains the scientific basis of Type 2 diabetes and its complications;

☞ Sheds light how Type 2 diabetes can be prevented and reversed by addressing all oxygen-related issues;

☞ Elucidates how toxicities of foods, environments, and thoughts cause tissue injury and lead to Type 2 diabetes;

☞ Reveals the mechanisms by which various detox therapies work (Oxygen is the primal detergent which removes cellular grease and allows cells to breathe freely); and

☞ Allows the formulation of rational and effective designs for reversing Type 2 diabetes; and

☞ Provides explanations of mechanisms by which time-honored natural remedies work to control and prevent Type 2 diabetes.

In general, fasting Blood sugar test is relied upon for screening for diabetes. I have seen many cases in which diabetes remained undiagnosed because the fasting blood sugar was below 100 mg/dL. Had a complete three-hour insulin test been done sooner, the diagnosis of diabetes would have been readily made.

Similarly, A1c test is not a reliable test for diagnosis. I have seen this test to also miss diabetes diagnosis. Again, if three-hour insulin test had been done sooner, the diagnosis of diabetes would have been readily made.

Some readers have been dismayed by my statement that diabetes is not a sugar problem.

Below are some questions they have raised. My answers follow the questions.

CHALLENGES

Ali’s is wrong. Everyone in the world knows that diabetes is a sugar problem,” one dissenter complained.

How can Dr. Ali be wrong and all other doctors in the world be wrong on the sugar-diabetes question?” another asked.

Doesn’t he know that blood sugar is high in diabetes? Why would doctors do blood testing if diabetes was not a sugar problem?

Doctors do blood A1c test. Isn’t it a sugar test,” comes another challenge.

RESPONSES

Everyone in the world knows that diabetes is a sugar problem. This not true. Scientists and well-informed doctors know that excess insulin (insulin toxicity) predates diabetes by five, ten, or more years.

All doctors in the world would be wrong on the sugar-diabetes question. No, all doctors would not be wrong. I have never met any doctor who denies the scientific facts that insulin toxicity (hyperinsulinism) predate Type 2 diabetes (the type of diabetes that affects more than 90% of diabetics in the world).

Does Dr. Ali know that blood sugar is high in diabetes? Yes, I know that. But blood sugar begins to rise years after blood insulin levels rise and begin to injure various body organs. I explain my simple point below with a kitchen gas rang” analogy.

Isn’t A1c test a test for blood sugar? Yes, it is, but this test is not a reliable test for screening for diagnosing diabetes. I have seen patients in which A1c is in the normal range and the patients has diabetes, and other patients whose A1c value is higher but a three-hour test for glucose does not sjows evidence of diabetes.

KITCHEN GAS STOVE ANALOGY

Let us suppose that the gas line in the basement of a house leaks for weeks and then one day there is a fire in the kitchen stove and the house burns down. What would we blame for the house fire, the leaking gas line in the basement or the kitchen stove?

The global tide of diabetes cannot be understood and stemmed without knowing the fundamentals of the molecular biology of insulin, a subject that is sadly and regularly neglected in the prevailing model of medicine. I wrote Insulin Toxicity Series to shed light on the various faces of this pandemic.

Seven Faces of insulin toxicity:

☞ The first stage of insulin toxicity is without apparent negative health effects recognized by the person.
☞ The second stage of insulin toxicity is with negative health effects recognized by the person but unknown to the doctor.
☞ The third stage of insulin toxicity is tissue injury (in the liver, kidneys, skin, and other organs) unrecognized by a doctor who is clueless about molecular biology of insulin.
☞ The fourth stage of insulin toxicity is prediabetes without tests to detect insulin waste and damages.
☞ The fifth stage of insulin toxicity is Type 2 diabetes with the use of diabetes drugs that add to the insulin activity, hence its toxicity, with the blessings of the American Diabetic Association).
☞ The sixth stage of insulin toxicity is toxicity created by peaks of insulin caused by insulin injections (the end-stage of insulin depletion which is called insulin-dependent diabetes).
☞ The seventh stage of insulin toxicity is loss of vision and blindness (diabetic retinopathy), dialysis (diabetic nephropathy), and increased risk of heart attacks, strokes, autoimmune diseases, inflammatory disorders, and all degenerative states.

I present evidence for all of the above in other articles in my Insulin Toxicity Series:

The take-home message of this article is: the use of diabetes drugs to lower blood sugar levels without non-drug plans to lower blood insulin levels is feeding the pandemic of insulin toxicity and diabetes. The American Diabetic Association and The New England Journal of Medicine teach doctors to use only drugs to lower blood sugar when what the people really need are programs to de-grease the cell membranes, free up insulin receptor proteins embedded in the membranes, and lower blood insulin levels.

The last article entitled “Insulin Toxicity and Metformin Mindlessness” reveals how many holistic doctors are succumbing to the lure of easy answers with drugs that do not address the real issues.

My Free Diabetes Course Has Two Parts: (1) Part One – Dr. Ali’s Insulin Toxicity Course; and (2) Part Two: Dr. Ali’s Diabetes Reversal Course. The first part of the course concerns the problem and the second part the solution.

Scientific Basis of Insulin-Based Diabetes Reversal

Five Threats to Humankind:

Developmental Challenges of the Unborn

Diabetes

Dialysis

Dementia

Disability

All five are rooted in insulin toxicity. I anticipate that some readers will roll their eyes on the first item listed above. That only means they are not aware of the frequency with which hyperinsulinism is encountered in children with autism, dysautonomia, OCD, POTS, and related neurodevelopmental challenges faced by children in prenatal and postnatal lives.

Oxygen Models of Insulin Toxicity and Diabetes Reversal Five Threats to Humankind:

Dr. Ali’s Insulin Toxicity Course and Dr. Ali’s Diabetes Reversal Course are based on Oxygen Models of Diabetes and Insulin Toxicity. Simply stated, these models explains all aspects of Type 2 diabetes—causes, clinical course, consequences, and control—on the basis of disturbed oxygen function. A full description of these models is included at the end of this article.

Body Organs of Special Interest inOxygen Models of Diabetes and Insulin Toxicity

Gut

Liver

Thalamus in the Brain

Muscles

Pancreas

Why Is the pancreas gland that produces insulin so low in the order of body organs?

I invite readers to keep this question in the mind as they consider my Course on Diabetes?

The Gut-Diabetes Connection

The Gut-Diabetes Connections

Throat

Esophagus

Stomach

Small intestine

Large intestine

Digestion starts within the mouth by the action of the enzymes in saliva. It then takes full effect within the stomach and some nutrients are also absorbed into the bloodstream here. Partially digested food known as chyme then undergoes further digestion mainly in the first part of the small intestine known as the duodenum. The small intestine, or small bowel, is the longest part of the gut and gradually the food is completely digested and almost all the nutrients are absorbed into the bloodstream.

The Thalamus-Feeding-Weight-Diabetes Connections

The Quick Facts

Location: Part of the forebrain, below the corpus callosumFunction: Responsible for relaying information from the sensory receptors to proper areas of the brain where it can be processed

The thalamus in the brain has special centers for glucose and regulates some aspects of sensory information that is being transmitted to the brain.

What Is More Important in Diabetes?

In Beta Cells of the pancreas where insulin is produced?

Or in cell membranes where it moves receptor proteins?

muscleWhere Insulin Is Produced Or Where It Is Used?

What Is Insulin? Where Does It Come From?

The pancreas is a long, slender organ, most of which is located posterior to the bottom half of the stomach. Although it is primarily an exocrine gland, secreting a variety of digestive enzymes, the pancreas has an endocrine function. Its pancreatic islets—clusters of cells formerly known as the islets of Langerhans—secrete the hormones glucagon, insulin, somatostatin, and pancreatic polypeptide (PP).

Pancreas

The pancreatic exocrine function involves the acinar cells secreting digestive enzymes that are transported into the small intestine by the pancreatic duct. Its endocrine function involves the secretion of insulin (produced by beta cells) and glucagon

☞ Insulin Toxicity Course (to Know the Problem Well

☞ Diabetes Reversal Course to Know then Solution Well for Reversing Diabetes?

I offer my course in two parts: (1) Dr. Ali’s insulin Toxicity Course; and (2) Dr. Ali’s Diabetes Reversal Course. I attribute the two parts of this course to myself for the simple reason that it makes it easier for people to find it on the internet.

The Oxygen Model of Diabetes provides a simple model that allows physicians to reduce complexities of diverse clinical syndromes into a workable simplicity.

This model predicts that ongoing research will reveal that components of acidosis (excess acidity), oxidosis (increased oxidative stress), and CUD (clotting-unclotting dysequilibrium) will be found to play important roles in the pathology and clinical features of Type 2 diabetes.

The crucial importance of the Unifying Oxygen Model of Type diabetes is that it:

☞ Explains the scientific basis of Type 2 diabetes and its complications;

☞ Sheds light how Type 2 diabetes can be prevented and reversed by addressing all oxygen-related issues;

☞ Elucidates how toxicities of foods, environments, and thoughts cause tissue injury and lead to Type 2 diabetes;

☞ Reveals the mechanisms by which various detox therapies work (Oxygen is the primal detergent which removes cellular grease and allows cells to breathe freely); and

☞ Allows the formulation of rational and effective designs for reversing Type 2 diabetes; and

☞ Provides explanations of mechanisms by which time-honored natural remedies work to control and prevent Type 2 diabetes.

In general, fasting Blood sugar test is relied upon for screening for diabetes. I have seen many cases in which diabetes remained undiagnosed because the fasting blood sugar was below 100 mg/dL. Had a complete three-hour insulin test been done sooner, the diagnosis of diabetes would have been readily made.

Similarly, A1c test is not a reliable test for diagnosis. I have seen this test to also miss diabetes diagnosis. Again, if three-hour insulin test had been done sooner, the diagnosis of diabetes would have been readily made.

Some readers have been dismayed by my statement that diabetes is not a sugar problem.

Below are some questions they have raised. My answers follow the questions.

CHALLENGES

Ali’s is wrong. Everyone in the world knows that diabetes is a sugar problem,” one dissenter complained.

How can Dr. Ali be wrong and all other doctors in the world be wrong on the sugar-diabetes question?” another asked.

Doesn’t he know that blood sugar is high in diabetes? Why would doctors do blood testing if diabetes was not a sugar problem?

Doctors do blood A1c test. Isn’t it a sugar test,” comes another challenge.

RESPONSES

Everyone in the world knows that diabetes is a sugar problem. This not true. Scientists and well-informed doctors know that excess insulin (insulin toxicity) predates diabetes by five, ten, or more years.

All doctors in the world would be wrong on the sugar-diabetes question. No, all doctors would not be wrong. I have never met any doctor who denies the scientific facts that insulin toxicity (hyperinsulinism) predate Type 2 diabetes (the type of diabetes that affects more than 90% of diabetics in the world).

Does Dr. Ali know that blood sugar is high in diabetes? Yes, I know that. But blood sugar begins to rise years after blood insulin levels rise and begin to injure various body organs. I explain my simple point below with a kitchen gas rang” analogy.

Isn’t A1c test a test for blood sugar? Yes, it is, but this test is not a reliable test for screening for diagnosing diabetes. I have seen patients in which A1c is in the normal range and the patients has diabetes, and other patients whose A1c value is higher but a three-hour test for glucose does not sjows evidence of diabetes.

KITCHEN GAS STOVE ANALOGY

Let us suppose that the gas line in the basement of a house leaks for weeks and then one day there is a fire in the kitchen stove and the house burns down. What would we blame for the house fire, the leaking gas line in the basement or the kitchen stove?

The global tide of diabetes cannot be understood and stemmed without knowing the fundamentals of the molecular biology of insulin, a subject that is sadly and regularly neglected in the prevailing model of medicine. I wrote Insulin Toxicity Series to shed light on the various faces of this pandemic.

Seven Faces of insulin toxicity:

☞ The first stage of insulin toxicity is without apparent negative health effects recognized by the person.
☞ The second stage of insulin toxicity is with negative health effects recognized by the person but unknown to the doctor.
☞ The third stage of insulin toxicity is tissue injury (in the liver, kidneys, skin, and other organs) unrecognized by a doctor who is clueless about molecular biology of insulin.
☞ The fourth stage of insulin toxicity is prediabetes without tests to detect insulin waste and damages.
☞ The fifth stage of insulin toxicity is Type 2 diabetes with the use of diabetes drugs that add to the insulin activity, hence its toxicity, with the blessings of the American Diabetic Association).
☞ The sixth stage of insulin toxicity is toxicity created by peaks of insulin caused by insulin injections (the end-stage of insulin depletion which is called insulin-dependent diabetes).
☞ The seventh stage of insulin toxicity is loss of vision and blindness (diabetic retinopathy), dialysis (diabetic nephropathy), and increased risk of heart attacks, strokes, autoimmune diseases, inflammatory disorders, and all degenerative states.

I present evidence for all of the above in other articles in my Insulin Toxicity Series:

The take-home message of this article is: the use of diabetes drugs to lower blood sugar levels without non-drug plans to lower blood insulin levels is feeding the pandemic of insulin toxicity and diabetes. The American Diabetic Association and The New England Journal of Medicine teach doctors to use only drugs to lower blood sugar when what the people really need are programs to de-grease the cell membranes, free up insulin receptor proteins embedded in the membranes, and lower blood insulin levels.

The last article entitled “Insulin Toxicity and Metformin Mindlessness” reveals how many holistic doctors are succumbing to the lure of easy answers with drugs that do not address the real issues.