In preclinical studies, and in Phase 1 and 2 clinical trials, AJA showed a favorable safety, tolerability, and pharmacokinetic profile. It also demonstrated significant efficacy in preclinical models of inflammation and fibrosis.

A new study has found that B-cell depletion therapy (which destroys autoimmune disease producing B cells) using rituximab has the potential to treat skin lesions in people with severe active cutaneous lupus erythematosus (CLE) and systemic lupus erythematosus (SLE).

Although treatment continues to advance, fatigue remains one of the most salient, poorly understood and addressed patient complaints. Understanding the mechanisms of fatigue can help guide the development of interventions to improve health outcomes.

Twelve weeks of aerobic exercise improved cardiovascular and respiratory fitness in systemic lupus erythematosus (SLE), but without positive changes in arterial stiffness that was this small study’s main goal.

Results also found no increase in signs of inflammation or oxidative stress in the exercise group compared to a control group urged to adopt a healthier lifestyle.

Scientists in South Korea have identified a switch that controls the expansion of a subset of immune cells involved in the development of systemic lupus erythematosus (SLE). Their findings are published in the journal Immunity.

People who have lupus and systemic vasculitis have weakened immune systems that are more susceptible to infections. Side effects of medication intended to help manage these diseases, specifically steroids and chemotherapeutics, can weaken the immune system further.

Specifically, they are at an increased risk for varicella-zoster virus (VZV) reactivation. VZV is the virus, which can cause chickenpox (varicella) and shingles (zoster). Once a person recovers from chickenpox, VZV remains inactive in the body. VZV can reactivate and cause a painful rash called shingles. There are many reasons why the virus can reactivate.

The Montreal Cognitive Assessment (MoCA) questionnaire is an easy-to-administer, inexpensive, effective screening tool that can identify patients with systemic lupus erythematosus (SLE) who might be at risk for cognitive dysfunction (CD) and might benefit from additional neuropsychiatric assessment, according to data published in Lupus.

The coagulation status of patients with systemic lupus erythematosus (SLE) is quite complicated, and there are currently no simple efficient methods for its evaluation. We explored the feasibility of thromboelastography (TEG) for this purpose.

Lupus nephritis is recurring less frequently among patients with end-stage renal disease who undergo kidney transplant, possibly due to improved immunosuppression, according to data presented by Debendra N. Pattanaik, MBBS, MD, of the University of Tennessee Health Science Center.Lupus nephritis is recurring less frequently among patients with end-stage renal disease who undergo kidney transplant, possibly due to improved immunosuppression, according to data presented by Debendra N. Pattanaik, MBBS, MD, of the University of Tennessee Health Science Center.

Lupus psychosis is a rare, potentially devastating, but treatable manifestation of systemic lupus erythematosus (SLE) that is associated with certain patient characteristics, analysis of data from a large inception cohort found.

Nitro-fatty acids — a type of fatty molecule naturally produced in the body — could act as natural inhibitors of the stimulator of IFN genes (STING), a protein involved in inflammatory diseases such as systemic lupus erythematosus (SLE), according to a study.

The study, “Nitro-fatty acids are formed in response to virus infection and are potent inhibitors of STING palmitoylation and signaling,” was published in the journal Proceedings of the National Academy of Sciences of the United States of America (PNAS).

A pilot clinical trial showed that bioelectronic medicine treatment was effective in reducing fatigue and pain in lupus patients. The researchers also saw a decrease in arthritis. A pilot study is a small-scale preliminary study that examines the feasibility of an approach that researchers intend to use in a larger scale study.

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