pain

If you feel pain, you feel acute physical or emotional discomfort. A sprained ankle will pain you. So will news of a loved one's death. If you "take pain" over something, it means you're being careful.

An annoying person can be described as a pain––it's understood that they don't cause you actual physical pain, but cause you emotional discomfort and distress. You can also describe this person as a "pain in the neck," "a pain in the butt," or "a royal pain."