This blog is published and maintained by Public Prosecutor P. M.Serrano Neves (pmsneves@gmail.com, Brazil) with the assistance of Acangau Foundation’s personnel and volunteers and contributors from all over the world. We strongly encourage participation and public debate.

Thursday, February 17, 2011

J Nutr. 2007 Dec;137(12):2798-804.Vahter ME.Institute of Environmental Medicine, Karolinska Institutet, 171 77 Stockholm, Sweden. marie.vahter@ki.seAbstractExposure to arsenic through drinking water is a major public health problem affecting most countries, although the situation is particularly severe in low-income nations. The health consequences of chronic arsenic exposure include increased risk for various forms of cancer and numerous noncancer effects, including diabetes, skin diseases, chronic cough, and toxic effects on liver, kidney, cardiovascular system, and peripheral and central nervous systems. In recent years increasing reports of effects on fetal and child development have appeared. There seems to be a wide variation in susceptibility to arsenic toxicity, which is likely to be related to factors such as variation in arsenic metabolism, nutrition, host-related defense mechanisms, and genetic predisposition. The main mechanisms of arsenic-nutrition interactions include arsenic-induced oxidative stress, which requires nutrient-dependent defense systems, and arsenic metabolism (methylation) via 1-carbon metabolism, which requires methyl groups, folic acid, vitamin B-12, and betaine for the remethylation of homocysteine to methionine. An efficient first methylation step in combination with a slow second methylation step seems to be most critical from a toxicological point of view. A third mode of arsenic-nutrition interaction involves epigenetic effects and fetal programming via DNA methylation.

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SOS Arsenic has been created in recognition of the urgent need to efficiently and democratically tackle the threatening issue of insidious contamination of our bodies and souls with anthropogenic arsenic both at local and global scales.

* SOS Arsenic has been created in recognition of the urgent need toefficiently and democratically tackle the threatening issue of insidious contamination of our bodies and souls with anthropogenic arsenic both at local and global scales.* It has been recognized that some media are financed by a fistful ofpeople, corporations and governments whose very existence, success and enrichment rely on arsenic-releasing activities such as gold mining.* This relationship of dependence has jeopardized the capacity of these media to adequately approach the arsenic contamination issue worldwide.* It has been recognized that the existence, richness and success of those few are built and maintained at the expenses of the existence, health and survival of the vast majority of people who suffer the burdens of arsenic contamination.* Democratic Right assists contributors to this blog in their task of contributing good quality scientific, artistic and journalistic information about arsenic contamination worldwide.* This is a legitimate journalistic endeavor of Orwellian stature: “Journalism is printing what someone else does not wanted printed; everything else is public relations” (George Orwell).* This blog is published and maintained by Public Prosecutor P. M.Serrano Neves (pmsneves@gmail.com, Brazil) with the assistance of Acangau Foundation’s personnel and volunteers and contributors from all over the world. We strongly encourage participation and public debate.