The "Pethouse Video" segment was filmed twice. Actress Monique Gabrielle is seen fully naked for the theatrical version for cinemas and released on DVD and home-video but is wearing lingerie for the television release.

The "release date" for the Amazon Women on the Moon movie in the segment of the same name keeps changing. "We now return to our feature film, the 1950s classic, Amazon Women on the Moon..." says some of the dialogue. The movie within this movie is dated in the film as being both a 1953 and 1954 release. The picture that it is based on, Cat-Women of the Moon (1953), was first released in 1953. At one point in Amazon Women on the Moon (1987), the film segment of the same title is referred to in a voice-over as "Amazon Women of the Moon", using the word "of" instead of "on", as with the title of its source Cat-Women of the Moon (1953).

Three segments which were deleted from the theatrical print have been reinserted in their entirety into television versions and included on the DVD's deleted scenes. The three segments are (1) "Peter Pan Theater" (Carl Gottlieb) (2) "The Unknown Soldier" (Peter Horton) and (3) "The French Ventiloquist's Dummy" (Joe Dante).

In the film within a film, "Amazon Women on the Moon," which is supposedly occurring in 1980 but made in the 1950s, Butch continually refers to things which have been long gone as though they are still around. The Brooklyn Dodgers, Ebbets Field, and a Studebaker are just a few examples. There is also a reference to the 48 U.S. states, when in actuality there have been 50 states since 1959.

The name of the television station during the "Amazon Women on the Moon" sketch (WIDB) is the name of a student-run radio station at Southern Illinois University in Carbondale, from which the film's director and producer Robert K. Weiss is a graduate.

The literal English translation of the French title of this Amazon Women on the Moon (1987) translates as "The Cheeseburger Movie" or "Cheeseburger Film Sandwich", whereas the literal English translation of the French title for this film's precursor, The Kentucky Fried Movie (1977), translates as being "The Hamburger Movie" or "Hamburger Film Sandwich".

The movie was filmed in 1985 but was not released theatrically until 1987. According to the '80's Movies Rewind' website, the picture was completed in 1986 but was not released in theaters for another year. It has been speculated that the reason for this was the court case that presenter and co-director John Landis was involved with relating to Twilight Zone: The Movie (1983).

Non-star billing for the movie's players during the beginning titles and on movie posters stated that the film starred "lots of actors" (in the opening credits) and "lots of other actors" (in the film posters).

The pair of critics, "Frankel and Herbert", in the segment "Critics' Corner", were played by a comedy team who also had a two-last-names stage name, "Lohman and Barkley", who were the real life comedy duo of Al Lohman and Roger Barkley.

All the real-life movies seen in the treasure trove of home video-cassettes in the "Video Pirates" segments were titles from the Universal Pictures studio who were not ironically this picture's production house.

In the segment "Video Date," as Ray seats himself in his easy chair to watch the video, there is a copy of Jimmy Olsen comics on a table next to the chair. Actor Marc McClure, who plays Ray, played Jimmy Olsen in Superman (1978) and its three sequels, as well as Supergirl (1984). The comic is Superman's Pal Jimmy Olsen #98, dated December 1966.

Scenes featuring two veteran character actors, Lyle Talbot and Dan Seymour, were cut from the finished film. Seymour played Dr. Muggs McGinty, a seedy racetrack doctor who treats Mary Brown in the "Reckless Youth" segment, and Talbot appeared as Prescott Townsend, head of the "American Space Association" in the "Amazon Women On the Moon" segment. Talbot's deleted scene is included in the Special Features on the movie's Collector's Edition DVD.

This movie, the one and only ever sequel [to date, August 2013], to The Kentucky Fried Movie (1977), was made and released in 1987, which was about ten years after The Kentucky Fried Movie (1977) had debuted in 1977. This sequel's title did not evoke the title of the first movie, though one of its working titles did, it being "The Kentucky Fried Sequel".

The "Amazon Women on the Moon" segment is credited as being produced by Samuel L. Bronkowitz who also receives a special thanks credit. The name is a joke fictitious name which was referenced considerably in the earlier film The Kentucky Fried Movie (1977).