Grey's Anatomy Season 9 Spoiler: Is a Major Breakup Coming Up?

Grey's Anatomy shippers should know by now that they are never safe. Despite the fact that Shonda Rhimes has said time and again that Meredith (Ellen Pompeo) and Derek (Patrick Dempsey) are in it for the long hall, their relationship could possibly be at risk come season’s end.Read spoilers at your own risk! For more on Wetpaint Entertainment's philosophy on spoilers, click here.

TVLine has given us yet another blind item, and we have cause to believe that it could be about two of our favorite Seattle Grace-Mercy West docs. (After all, the last one was.)

TVLine states that a major beloved couple in an hour-long drama will call it quits before heading into what could be the show’s last season. They narrow it down to nine possibilities, and the list includes MerDer andCallie (Sara Ramirez) and Arizona (Jessica Capshaw).

The split is described as an unexpected jolt that would give the writers a lot of creative opportunities going into the next season.

Could Meredith and Derek give up on their marriage? If so, why? And what about Calzona? Will they ever recover from the effects of the plane crash?