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Description

The explosion of the field of genetics over the last decade, with the new technologies that have stimulated research, suggests that a new sort of reference work is needed to keep pace with such a fast-moving and interdisciplinary field. Brenner's Encyclopedia of Genetics, Second Edition, builds on the foundation of the first edition by addressing many of the key subfields of genetics that were just in their infancy when the first edition was published. The currency and accessibility of this foundational content will be unrivalled, making this work useful for scientists and non-scientists alike.

Featuring relatively short entries on genetics topics written by experts in that topic, Brenner's Encyclopedia of Genetics provides an effective way to quickly learn about any aspect of genetics, from Abortive Transduction to Zygotes. Adding to its utility, the work provides short entries that briefly define key terms, and a guide to additional reading and relevant websites for further study. Many of the entries include figures to explain difficult concepts. Key terms in related areas such as biochemistry, cell, and molecular biology are also included, and there are entries that describe historical figures in genetics, providing insights into their careers and discoveries.

Key Features

This 7-volume set represents a 25% expansion from the first edition, with over 1600 articles encompassing this burgeoning field.

Thoroughly up-to-date, with many new topics and subfields covered that were in their infancy or not inexistence at the time of the first edition. Timely coverage of emergent areas such as epigenetics, personalized genomic medicine, pharmacogenetics, and genetic enhancement technologies

Interdisciplinary and global in its outlook, as befits the field of genetics

Brief articles, written by experts in the field, which not only discuss, define, and explain key elements of the field, but also provide definition of key terms, suggestions for further reading, and biographical sketches of the key people in the history of genetics.

Readership

Intended for university libraries, researchers, undergraduate and graduate students, instructors, and clinicians in genetics, genomics, molecular biology, biotechnology, systems biology, structural biology, evolutionary biology, microbiology, and related life science areas. It is likely to be of interest to pharmaceutical and biotechnology companies and government and private consulting agencies in related fields.

Table of Contents

Editors-in-Chief

Section Editors

Preface

Brenner’s Encyclopedia of Genetics, 2nd Edition

Permission Acknowledgments

A

Abortive Transduction

See also

Further Reading

Glossary

Acentric Fragment

See also

Achondroplasia

See also

Further Reading

Relevant Websites

Glossary

Acridines

See also

Further Reading

Glossary

Acrocentric Chromosome

See also

Acrosome

See also

Active Site

See also

Adaptive Landscapes

Overview

Adaptive Landscapes as Described by Wright

Evolution on Rugged Adaptive Landscapes

Allele Frequency Landscapes

Maynard Smith’s (Protein) Sequence Space

Phenotypic Landscapes

Do Fitness Valleys Matter?

Future Prospects

See also

Further Reading

Glossary

Adaptive Mutation

See also

Further Reading

Glossary

Adaptor Hypothesis

See also

Additive Genetic Variance

Variation and Its Components

Definition of the Additive Genetic Variance

The Correlation between Relatives

Evolutionary Considerations

See also

Further Reading

Glossary

Adenine

See also

Adenocarcinomas

Introduction

Breast Adenocarcinoma

Prostatic Adenocarcinoma

Adenocarcinoma of the Lung

Colorectal Adenocarcinoma

Pancreatic Ductal Adenocarcinoma

Conclusions

See also

Further Reading

Relevant Websites

Glossary

Adenoma

See also

Further Reading

Adenomatous Polyposis Coli

Introduction

Molecular Organization

Homologs

Function

Pathology

See also

Further Reading

Relevant Websites

Glossary

Adenosine Phosphates

See also

Adenoviruses

Introduction

Replication Cycle

Oncogenic Transformation

Adenovirus Transducing Vectors (Gene Therapy)

Adenovirus Genomics and Bioinformatics

See also

Further Reading

Glossary

Adjacent/Alternate Disjunction

See also

Further Reading

Relevant Websites

Glossary

Advanced Glycation End-Products

End-Product Inhibition

Inhibitors of AGE Formation

Further Reading

Relevant Websites

Glossary

Advanced Intercross Lines

Introduction

Producing the AIL: The F2 Generation

Producing an AIL: The F3 and Subsequent Generations

Accumulation of Recombination Breakpoints in the AIL

Mapping Accuracy in an AIL

Variation in Allele Frequency and Recombination in AIL

The Phenotyped Population

Modified AIL Designs

See also

Further Reading

Glossary

Aflatoxins

Background

Introduction

Natural Occurrence

Favorable Environmental Conditions

Analysis Techniques for AF Determination in Food and Food Products

Toxicity of AFs

Regulations on AFs

Reduction Techniques

Conclusion

See also

Further Reading

Relevant Websites

Glossary

Aging, Genetics of

Introduction

Evolutionary Origins of Aging

Molecular Mechanisms of Aging

Aging in Model Genetic Systems

Modulation of Aging by Nutrient Response Pathways

Human Aging

See also

Further Reading

Relevant Websites

Glossary

Agouti

See also

Agrobacterium

General Properties of Agrobacteria

Agrobacterium as Phytopathogen

Agrobacterium as Genetic Engineering Tool

Agrobacterium as Experimental System for Fundamental Cell Biology

See also

Further Reading

Relevant Websites

Glossary

Agrobacterium and Ti Plasmids

Introduction

General Properties of Agrobacteria

Agrobacterium Ti Plasmid As Gene Vector for Plant Genetic Engineering

Agrobacterium Basic Research

See also

Further Reading

Glossary

Alanine

See also

Albinism

Characteristics and History

Biochemistry and Molecular Genetics

See also

Further Reading

Relevant Websites

Glossary

Alcoholism

Clinical Findings

Findings from Animal Models

Conclusions

See also

Further Reading

Relevant Websites

Glossary

Alignment Problem

Sequences

Alignment Is Important

Alignment Parameters

Alignment Methods

See also

References

Alkaptonuria

Introduction

HGD Gene

Metabolic Consequences of HGD Deficiency

Ochronosis

Clinical Manifestations

Therapy

Misdiagnosis of AKU

Animal Models

See also

Further Reading

Relevant Websites

Glossary

Alkyltransferases

See also

Allele Frequency

See also

Further Reading

Relevant Websites

Glossary

Alleles

See also

Further Reading

Allele Specificity

See also

Relevant Websites

Glossary

Allelic Exclusion

See also

Allopatric

See also

Allostery

Introduction

Origins

Specific Examples

See also

Further Reading

Allotypes

See also

Further Reading

Relevant Websites

Glossary

Alpha1-Antitrypsin Deficiency

Introduction

Gene, Protein, and Mutations

Pulmonary Disease

Pulmonary Disease in Heterozygotes

Liver Disease

Therapy

Conclusion

See also

Further Reading

Glossary

Alpha-Complementation

See also

Further Reading

Glossary

Alpha-Fetoprotein

History

Gene Structure and Regulation

Protein Structure and Function

Clinical Significance

Future Considerations

See also

Further Reading

Relevant Websites

Glossary

Alternation of Gene Expression

Introduction

Site-Specific Inversion and Alternation of Gene Expression

Reversible Insertion of IS Elements and Phase Variation of Gene Expression

Details

About the Editor

Sydney Brenner

Affiliations and Expertise

Institute of Molecular Scieces, Berkeley, Califoria, U.S.A.

Jeffrey Miller

Affiliations and Expertise

University of California, Los Angeles, U.S.A.

Reviews

"The revised version features more than 1,600 articles, representing an increase in content of approximately 25 percent over the first edition (2002),…Important updates include entries on new topics such as epigenetics and pharmacogenetics, which help provide a foundation for personalized medicine based on genome sequence…Summing Up: Recommended."--Choice Reviews Online, April 2014

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