Additional files

Additional file 1:

Additional materials and methods and Additional Tables. Detailed methods describing technicalities of the database integration and algorithms,
with the following sections. Knowledge integration: detecting hub nodes by computing
a priori probabilities with random walks; computing a posteriori probabilities and ranking relations; backtracking heuristic for the automated generation
of functional hypotheses; additional results. Additional Table 1: top 50 hubs or highest
ranking concepts of the computation of the a priori rank score in the integrated network. Additional Table 2: area under the receiver
operator characteristic (ROC) curve (AUC) for the prioritization of disease genes
in the Endeavour benchmark. Additional Table 3: effect on the Endeavour benchmark
after leaving out each separate database from the data integration process.