Your doctor will perform blood tests to make sure you do not have conditions that would prevent you from safely using mipomersen.

Using mipomersen during pregnancy could harm the unborn baby. Tell your doctor if you are pregnant or if you become pregnant while using this medicine. Use effective birth control during treatment.

It is not known whether mipomersen passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine.

How is mipomersen given?

Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.

Mipomersen is injected under the skin. You may be shown how to use injections at home. Do not self inject this medicine if you do not understand how to give the injection and properly dispose of used needles and syringes.

Mipomersen is usually given once per week. Use this medicine on the same day each week, at the same time of day.

Use a different place on your stomach, thigh, or upper arm each time you give the injection. Your care provider will show you the best places on your body to inject the medication. Do not inject into the same place two times in a row.

Mipomersen is only part of a treatment program that may also include a special diet and other medications. Follow your doctor's instructions very closely.

Mipomersen should be stored in a refrigerator, if possible.

Mipomersen must be at room temperature at the time of injection. Take a vial or prefilled syringe out of the refrigerator and allow it to reach room temperature before giving an injection. Do not heat the medicine before using. Do not remove the needle cover from the prefilled syringe until you are ready to give the injection.

Mipomersen may also be stored at room temperature for up to 14 days. Keep the medicine in its original container and protect from heat or light.

Prepare your dose only when you are ready to give an injection. If you use any other injectable medication, do not mix it with mipomersen or inject it at the same time you inject mipomersen.

Do not use the medicine if it looks cloudy or has particles in it. Call your pharmacist for new medicine.

Each single-use vial (bottle) or prefilled syringe is for one use only. Throw away after one use, even if there is still some medicine left in it after injecting your dose.

Use a disposable needle only once, then throw away in a puncture-proof container (ask your pharmacist where you can get one and how to dispose of it). Keep this container out of the reach of children and pets.

Mipomersen can cause your liver enzymes to get too high. Your blood will need to be tested often. Your weekly treatments may be delayed or permanently discontinued based on the results of these tests.

What happens if I miss a dose?

Use the missed dose as soon as you remember. Skip the missed dose if your next dose is less than 3 days away. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while using mipomersen?

Avoid injecting mipomersen into skin areas that are swollen, irritated, sunburned, or affected by conditions such as psoriasis or a skin rash. Also avoid injecting into any skin area with a scar or tattoo.

Avoid drinking more than 1 alcoholic drink per day. It may increase your risk of liver damage while you are taking mipomersen.

Avoid eating foods that are high in fat or cholesterol. Mipomersen will not be as effective in lowering your cholesterol if you do not follow a cholesterol lowering diet plan.

Mipomersen side effects

Get emergency medical help if you have signs of an allergic reaction:hives; difficult breathing; swelling of your face, lips, tongue, or throat.

What other drugs will affect mipomersen?

Other drugs may interact with mipomersen, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

Related treatment guides

Where can I get more information?

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.