What are the complications if cyclic vomiting syndrome is not treated?

If the condition is not treated, attacks typically occur four to 12 times per year. Between episodes, vomiting is absent, and nausea is either absent or much reduced. However, many affected people experience other symptoms during and between episodes, including pain, digestive disorders such as
gastroesophageal reflux and irritable bowel syndrome, and fainting spells (syncope). People with cyclic vomiting syndrome are also more likely than people without the disorder to experience depression, anxiety, and
panic disorder. It is unclear how these health conditions are related to nausea and vomiting.

What is the relationship between cyclic vomiting syndrome and migraines?

Cyclic vomiting syndrome is generally considered to be a variant of
migraines, which are severe headaches often associated with pain, nausea, vomiting, and extreme sensitivity to light and sound. Many people with cyclic vomiting syndrome have a family history of migraines, and attacks of nausea and vomiting may be replaced by migraine headaches as an affected person gets older.