We know that point mutations are introduced into the variable regions
of immunoglobin genes when rechallenged with antigen and b cells are
selected which have higher affinity than the "mother" B-cell. I know this
probably happens in germinal centers and that b-cells producing either
self directed immunoglobin or ineffective antibodies are delected.
But does anyone have ideas on how genes produce rapid rates of mutation?
And especially involving only variable regions?