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Sir: In their recent article, Posternak and Zimmerman1 question
whether there is a several-week delay in “true antidepressant
effect.” They propose to address this issue by a
meta-analysis to determine (1) “whether significant drugplacebo
separation occurs during the first 2 weeks of treatment”
and (2) “whether the timing of response to antidepressant medication
and placebo is distinct.”1(p148)
Since the issue centers on “true antidepressant effects,” measures
and analyses must address this salient point.​