A true story of corruption, greed and lust for power.

While investigating statins, we were faced with big words
like “3-Hydroxy-3-Methyl-Glutaryl Coenzyme-A reductase”, sometimes shortened to
“HMG-CoA reductase” or better yet “reductase”. What to do?

To be understood, this report had to be simple.

Here is simple: we got shafted. The NIH and associated
agencies blew over a half a billion dollars of our money. The FDA may as well
have not existed. We have been lied to, stolen from and poisoned by the
pharmaceutical industry.

No surprises here; business as usual.

Another part of biochemical language became apparent.
Biochemistry is riddled with words and phrases like, “may, might, could, this
might mean, putative (supposed), pleiotropic (many) and unknown mechanism”. The
chemist might describe it something like this: “a proliferation of putative,
pleiotropic inexactitudes”.

Is biochemistry an inexact science?

No. It is a science of proven results that are reproducible,
consistent and understandable.

When it comes to approving drugs for profit it is easy to obscure
proven results with caveats like “may or might or unknown mechanism”. After
all, that is the language of biochemistry. When seeking FDA approval, those
words become the lies of the pharmaceutical industry. Those words are honest
words for unproven science; those are words that cannot be trusted when money
is involved.

When it comes to drugs versus sound science, absolute
science can be quickly obscured by the smoke screen of relative statistics.

Statistics don't lie, but liars use statistics.

Conflicts-of-interest become the enemy of a universally accepted
proven scientific body of evidence. Absolute truths are buried by relative
lies.

All of lipid theory “evidence” linking cholesterol to
cardiovascular disease is based on relative statistics. True believers like
Steinberg have agendas.

True believers are a dangerous lot. They fought on both
sides in the crusades and presided over the Spanish Inquisition. They brought
the Nazis to power in Germany and brought down the twin towers on 9/11.

Steinberg and his comrades are the true believers of this
report. They skewed the statistics to save us from ourselves – even if it kills
us. They are like the religious right that brought us prohibition, Al Capone,
segregation and lynch mobs.

Scientists free of hidden agendas like Siperstein had proven
statins were deadly long before a corrupted FDA approved them. Steinberg infected
his colleagues and convinced the FDA that a deadly fungal toxin was good for
all of us.

The drug companies that sell statins benefit from relative
statistics used to obfuscate hard science. They dress it up with phrases like
“evidence-based medicine”, “peer-reviewed report” and “double-blind study.”
Dress up a pig, it is still a pig.

Misuse of statistics is a malignant cancer on medicine.

Two hundred million users at $2 per toxic dose and $400,000,000 per day yields enough gross resources
to hire a whole army of ghostwriters to publish bogus claims and bury absolute
science with relative statistics. This “malignancy” props up a $146,000,000,000
per year windfall to the drug industry—all built on lies.

This report tracks the liars and the lies about one of the
statin drugs (lovastatin) from one of the drug companies (Merck). This is because
lovastatin was the first of all the currently prescribed statins and Merck is
responsible for its approval.

In short:

Statin research was
founded on scientific assumption and an agenda.

Statins are dangerous
drugs developed in error for profit.

Scientific evidence had
proven that statins were lethal years before lovastatin’s approval.

Merck corrupted the
science and the scientists.

The approval process was
so corrupted by Merck that lovastatin was bound to be approved.

Merck lied.

The FDA shirked its duty; neithersafety nor
efficacy was proven for statins.

Statins are derived from
fungal toxins that block cell growth and replication.

Untold harm is being done
to millions of human beings.

All of this is recorded in and gleaned from the public
record.

In 1989, Thomas J. Moore wrote an investigative report
called “The Cholesterol Myth”. He reviewed all the statistics published on
three major NIH studies mounted with public funds (costing us over
$500,000,000). He converted those relative statistics into their most
understandable and absolute form. From
his work, the following is clear:

There is no credible proof
that high blood cholesterol and cardiovascular disease (CVD) have a causal
connection.

Diet and exercise do not
help.

There is no good reason to
prescribe statins to anyone.

If there was any justification for lowering cholesterol from
NIH's $500,000,000 studies, and a safe way could be found, it should be
administered to only one small group of men aged 28 to 45. The entire myth was
built around that group.

Irrefutable, reproducible science proves statins are deadly
and LDL cholesterol is vital for life. Universal biochemistry convention proves
statins kill organs and organisms, one cell at a time.

This report expands on the following publicly recorded
events:

1957:
Japanese biochemist Akira Endo graduates from Tohoku University and joins
Sankyo Pharmaceuticals in Tokyo. He receives a PhD in 1966 from Tohoku for
his work at Sankyo.

1959:
FDA approves MER/29 as the first cholesterol-lowering drug that blocked
the mevalonate pathway and is an instant success.

1959-1961:
Multiple reports are published hailing the benefits of MER/29 for lowering
cholesterol.

1961:
A MER/29 lab worker complains to her husband that lab animal data is
falsified. Her husband, who car-pools with an FDA investigator, reports
his wife's complaint. FDA performs an unannounced record search.

1962:
MER/29 is removed from the market after FDA discovers the William S.
Merrell Company had omitted preclinical findings of cataracts in rats and
dogs, muscle wasting in monkeys and other falsified or unreported data.

1963:
A federal grand jury indictment is issued against Merrell Co. and some of
its employees. Scientists and executives plead “no contest”, which protects them against the
grand jury findings in subsequent class-action civil suits. Multi-millions
are awarded to the victims.

1960-1975:
Drug companies enter the “mycotoxin gold rush” after a fungal toxin
(aflatoxin) was found to cause cancer epidemics in grain-fed domestic trout
and turkeys.

1976:
Endo abandons his work with citrinin because it is too toxic. He extracts
another mycotoxin from Penicillium
citrinum called “ML-236B” which proves less toxic than citrinin and
also lowers blood cholesterol. ML-236B becomes the first experimental
statin.

1982:
Under arrangements approved by the FDA, Merck makes lovastatin available to
Grundy, Bilheimer and Brown at Dallas for FH patients who had failed known treatment modalities. An IND
(Investigational New Drug) permit is granted for human experimentation in
Dallas.

1984:
Merck applies for an IND for lovastatin and a new drug application (NDA)
is approved in nine months – one of the shortest approval times for the
FDA since MER/29.

1985:
The NIH launches the National Cholesterol Education Program (NCEP).
Steinberg positions his colleague Grundy to chair the NCEP.

1987
(February 19): Brown and Steinberg represent Merck at the FDA advisory
committee meeting on lovastatin. There is no disclosure on the increase in
reductase and resultant cell injuries from mevalonate deprivation that are
said, by Merck's MacDonald and Tobert, to be due to an unknown mechanism.

1990: The
NIH convenes a panel to discuss the possibility that decreasing
cholesterol levels might be intrinsically dangerous. The panel concludes
that the evidence cannot be ruled out but dismisses it anyway.

2001: Bayer's “super-statin” Baycol is recalled after
multiple deaths are attributed to the drug.

Greed smothers the conscience. Drug cartels, legal or
illegal, pursue another agenda that rivals the evil of true believers. The
vampire turns his hypnotic gaze on his victim: “You will live forever,” he whispers. He does not rightfully hiss, “You
will sleep alone in a casket and never see the sun again.”

Today, statins remain the most insidiously
dangerous and best-selling drug in the world.

In this book, “cardiovascular disease” is
abbreviated as CVD. CVD includes coronary heart disease, atherosclerosis
(hardening of the arteries), heart failure, high blood pressure and stroke.

The following Preface is from the book, "How Statin Drugs REALLY Lower Cholesterol (And Kill You One Cell at a Time) NOW AT AMAZON:

Preface

Seventy million Americans and over two hundred million people worldwide
are taking a deadly drug called statins. How did this happen? Whose fault is
it?

The record reads like an Edgar Allen Poe novel. It did not start
with some grand conspiracy. It became one.

It was an insidious creeping cancer, a combination of events and
history. It was capitalism running amuck. It was the rise to power of one true
believer. It was competition and greed. It was corruption of good science and
good scientists. It was deregulation of the FDA. It was pride and prejudice and
the residual of WWII.

It was a poison so tiny it went unnoticed. It crept into the
culture in the name of good and infected everyone it touched with evil.

By 1930, cardiovascular disease (CVD) had become the leading cause
of death of Americans. It was an enemy to be stopped.

In 1913, a Russian scientist named Nicolay Anitschkow released a study
that grass-eating rabbits developed CVD when force-fed an all-cholesterol diet.

The evil seed was planted.

When WWII broke out the “Japs” became America’s archenemy. Movies,
news articles and newsreels portrayed them as diabolical “slant-eyed” demons.
It was a national agenda: “Beat the Japs”. The residual prejudice of that war
would play into the development and widespread acceptance of statins.

In 1948, the largest tax-paid study ever mounted on heart disease
began in a small town called Framingham. The cost of it would eventually amount
to hundreds of millions of dollars. It was established on a flawed agenda. It
set out to prove the relationship of high LDL cholesterol to heart disease (the
lipid theory). It failed. But millions of taxpayer dollars had been
spent and reputations and jobs were on the line; it had to succeed.

The evil began to grow.

The Framingham study proved that if you were male, between the
ages of 28 and 45, lived in Framingham and had high LDL cholesterol levels, you
had a 2% greater chance of dying from a heart attack or stroke than the
national average. On that one statistic a national health agenda began: stamp
out high LDL cholesterol in everyone. The lower the better.

The evil began to spread.

In 1957, a young Japanese scientist named Akira Endo graduated from
Tokyo Noko University and joined Sankyo – a Japanese drug company. His part in
the coming travesty would not be known until much later.

In 1959, the William S. Merrell Company pushed through the FDA, in
record time, a drug called triparanol (MER/29). It lowered cholesterol by
blocking the same biochemical path as statins.

Cataracts, skin lesions, hair loss, impotence and neuropathy began
to develop in the patients. Whistle-blowers came forward. Merrell Co. had lied
and withheld information pertinent to approval. Heads rolled, people were
convicted, lawsuits abounded and the drug was withdrawn in 1962.

MER/29 was a hugely profitable and popular drug.

Enter Daniel Steinberg MD, PHD, NIH investigator, egomaniac and
true believer. He led the science team that dismantled MER/29 and had advised
the FDA against approval. His stature rose far beyond that of a public servant
just doing his job. In time, he became an NIH chief with far-reaching
influence. In third-person language of a narcissist, he would later publicize
himself as a hero in structuring FDA’s approval of statins: “Daniel Steinberg
did this. Daniel Steinberg did that.”

Steinberg hails Nikolai Anitschkow as the first lipid theorist worthy of the Nobel
Prize – having supposedly first proved that LDL cholesterol is the cause of
heart disease. He would spend hundreds of millions of taxpayer dollars on the
CPPT (Coronary Primary Prevention Trial). It failed.

Undaunted, he would manipulate the statistics to be right
regardless the true results. That had already been done with the Framingham
study. He perverted an absolute statistic of less than two percent in the CPPT
study into a 19% relative statistic. He then declared the cholesterol wars over
and the lipid theory factual science. He gathered like-minded true believers
and formed the NIH “consensus panel” on cholesterol.

In 1980, statin development came to a screeching halt due to
cancer in Sankyo’s lab animals. Daniel Steinberg and Akira Endo would resurrect
its development.

In 1981, Endo published the results of clandestine human studies
in Japan. Steinberg consulted Merck and the FDA, discredited Sankyo’s findings
of cancer in more than half their statin-fed dogs and helped pave the way for starting
human trials in the U.S. so as to beat Japan in a “knock-down drag-out race” –
an ugly leftover from WWII.

In 1982, human studies began on Merck’s lovastatin at a university
in Dallas using NIH grant funds. The taxpayers would pay for Merck’s trials.

In February 1987, Daniel Steinberg, the former NIH chief turned
Merck’s advisor, would be the first speaker at the FDA advisory committee meeting
on statins, held at the NIH.

In August 1987, the FDA approved lovastatin.

In October of 1987, the National Heart, Lung and Blood Institute
(of the NIH) launched the largest free advertising program ever devised: the
National Cholesterol Education Program (NCEP). Steinberg again led the way. At
taxpayer expense, Americans were screened and 25% prescribed statins to take
the rest of their lives. The taxpayers would pay another 150 million dollars to
advertise for Merck. Steinberg would brag of his involvement in his later
writings.

The evil had overcome the land like the creeping vines of Japanese
kudzu had swept over southern farmlands and immersed them in a tangled
impenetrable web.

Even leeches and bloodletting have proved more useful and safe
than statins.

Never in the history of medical science has one man and his followers
done so much harm to so many. Steinberg
et al. have been beating a dead horse.
The myopia of their dead science and findings have harmed and killed too many
to count.

Akira Endo is another dangerous and driven man.

There
was only one thing certain about Anitschkow’s rabbits: they are natural vegetarians that do not
normally suffer cardiovascular disease. The cholesterol they were fed was never
the enemy. The quantum leap that even Anitschkow did not make linking cholesterol
to heart disease was not just bad science.

Sunday, April 1, 2012

We recently received an email from a disgruntled doctor in San Diego who complained
we were encouraging malpractice suits.

She said her insurance provider would financially penalize the people in her
medical group if they did not keep cholesterol below certain levels -- and that we were
coming against the best tool that could achieve those goals.

We sent a quick response and encouraged her to wrestle with the powers that
be and help us take the practice of medicine back from the drug cartels and
insurance providers.

In hindsight we might have written this:

Dear Doctor X,

Where is your outrage?

If what we have written is true, and it is, then an appropriate response
would be, “I will not practice medicine again rather than prescribe another
statin. I will help anyone suffering statin toxicity for free. I will help
any patient sue these sonsabitches. I will testify for them.”

Either help us stop this madness or at the very least get out of the way
with your selfish concerns about what is going to happen to you.

Drug company personnel are knowingly and deliberately ignoring science for profit. They are poisoning your family, friends, patients and
now recommending these poisons for your children.

Where is your conscience? What could you be thinking?

Of course we wrote for the lawyers. Who else might have enough clout to
bring an end to this insanity? What else might engender enough fear in the
medical community to start at least a little resistance? What happened to the
oath to "do no harm"?

If doctors do not have enough concern to help, then only the lawyers and
patients can provide a remedy.

We have deliberately and knowingly lit a match to a box of tinder that sits
on top a trainload of dynamite which is parked in the middle of medicine, as
we now know it.

Big pharma, the FDA, the NIH, the AMA, the AHA or any other corrupt or corruptible
companies or agencies must not control medicine.

Medicine must be returned to the doctors with enough courage to practice it in
earnest. The doctors who sit on their dead asses, collect their big paychecks
and prescribe these poisons need to be rooted out of medicine.

Stop, for God’s sake stop and think. Get informed. Ignorance is not an
acceptable excuse.

In any case, the match is lit. On which wagon are you going to be: big pharma's or the victims'?

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About Me

The Yosephs have written the most stunning exposé. In simple language they reveal the science, the corruption and the enormous conspiracy it took to bring statins to market. As fast paced as a Mickey Spillane novel they report the research, the fraud and the facts like a detective in hot pursuit of a Nazi war criminal. Once picked up it cannot be put down until the reading is done. It is riveting. They have accomplished the impossible: they have made both complex science and medical history fascinating to read. What could not be done in an exposé they accomplished with almost unbelievable ease. It will change your paradigms about medicine forever. Read it!