Angiosarcomas, are the most aggressive of the three, frequently having metastases at the time of diagnosis (and there carrying an extremely poor prognosis), and often having local recurrences.

Epidemiology

They account for less than 1% of all sarcomas and are more frequently seen in males (M:F = 2:1) except when seen in the setting of post-mastectomy lymphoedema which is clearly more common in women and is known as Stewart-Treves syndrome.

Pathology

The malignant cells express morphological and functional properties of endothelial cells. The tumours can be multicentric with haemorrhage and necrosis being common.