Professionals working with immigrant and refugee youth in schools, mental health clinics, hospitals, and adolescent-serving organizations are better equipped to offer culturally appropriate interventions and prevention strategies if they understand their clients' migration journeys and legal status. Professionals who understand the cultural values of immigrant and refugee youth and families are also better prepared to recognize the strengths and protective factors present in those cultural values when developing prevention strategies. This article will explore these three important factors--legal statuses, migration experiences, and the strength of cultural values--and offer practical prevention strategies. (Contains 1 table.)