Bromopheniramine
Synthesis Reference

Bromopheniramine
Molecular Weight

Bromopheniramine
Melting Point

Bromopheniramine
H2O Solubility

Bromopheniramine
State

Solid

Bromopheniramine
LogP

3.74

Bromopheniramine
Dosage Forms

Tablet

Bromopheniramine
Indication

For treatment and relief of symptoms of allergies, hay fever, and colds

Bromopheniramine
Pharmacology

In allergic reactions an allergen interacts with and cross-links surface IgE antibodies on mast cells and basophils. Once the mast cell-antibody-antigen complex is formed, a complex series of events occurs that eventually leads to cell-degranulation and the release of histamine (and other chemical mediators) from the mast cell or basophil. Once released, histamine can react with local or widespread tissues through histamine receptors. Histamine, acting on H1-receptors, produces pruritis, vasodilatation, hypotension, flushing, headache, tachycardia, and bronchoconstriction. Histamine also increases vascular permeability and potentiates pain. Dexbrompheniramine is a histamine H1 antagonist (or more correctly, an inverse histamine agonist) of the alkylamine class. It provides effective, temporary relief of sneezing, watery and itchy eyes, and runny nose due to hay fever and other upper respiratory allergies.

Bromopheniramine
Absorption

Antihistamines are well absorbed from the gastrointestinal tract after oral administration.

Bromopheniramine
side effects and Toxicity

Signs of an overdose include fast or irregular heartbeat, mental or mood changes, tightness in the chest, and unusual tiredness or weakness.