演題詳細

Tokizane Award Lectures

ヒトの恐怖と闘争に関して魚は何を教えてくれるか
What do fish teach us about our fear and aggression?

AL-2

岡本 仁 / Hitoshi Okamoto:1

1:独立行政法人 理化学研究所 脳科学総合研究センター / RIKEN Brain Science Institute

The fish brains are by far more similar to the mammalian brains than people used to think, and are now regarded as among the most suitable models to study the neural tmechanisms of emotional behaviors. The habenula (Hb) is such an evolutionarily conserved diencephalic structure. We recently discovered that the dorsal and ventral Hb (dHb and vHb) of zebrafish correspond respectively to the medial and lateral regions (MHb and LHb) of mammalian Hb.
Our recent data showed in zebrafish that the projection from Hb to the median raphe transmits the shock-predicting negative reward expectation value to the reinforcement learning system and enables the behavioral transition from panic to adaptive active avoidance to cope with fear.
In zebrafish, the lateral subnuclei of the dorsal habenula (dHbL) are asymmetrically connected with the dorsal and intermediate parts of the interpeduncular nucleus (d/iIPN). This pathway further projects to the region containing the equivalents of the dorsal raphe, the periaqueductal gray, and the dorsal tegmental nuclei. Specific silencing of the dHbL-d/iIPN pathway rendered animals extraordinarily prone to freeze in response to conditioned fear stimuli, while the control fish showed only flight behaviors, implicating this pathway in experience-dependent reevaluation of danger during the fear conditioning trials.

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