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Hurst said the drug network included elements in Texas, California, Tennessee, Alabama, Georgia, and Mississippi. It involved the distribution of over 40 kilograms of methamphetamine, over 3 kilograms of cocaine and over 100 pounds of marijuana.

"This trafficking organization is not just in Mississippi, but it's encompassed in several states. Instead of just going after the individual purchasers or the individual dealers, we have to hit the whole network in order to dismantle it and stop the supply of it and end it from harming our citizens in our communities," Hurst said.

Eight of the 11 indicted were from Philadelphia.

"This criminal organization is responsible for a significant portion of the illegal narcotics coming into not only Philadelphia but east central Mississippi as well," said Philadelphia Police Chief Grant Myers. "Almost all of the crimes we deal with, from assaults to thefts, and everything in between, can be traced back to illegal narcotics. Taking down an organization of this size will have a significant impact on crime in our area.”

The following individuals have been indicted as a result of Operation Highlife:

Brandon Deshanta Miller, 32, of Dallas, is charged with conspiracy to possess with intent to distribute 50 grams or more of methamphetamine, possession with intent to distribute 50 grams or more of methamphetamine, and being a felon in possession of a firearm. If convicted, Miller faces up to life in prison and a $30.25 million fine.

Shandlette Hudson, 42, of Philadelphia, is charged with conspiracy to possess with intent to distribute 50 grams or more of methamphetamine and possession with intent to distribute 50 grams or more of methamphetamine. If convicted, Hudson faces up to life in prison and a $20 million fine.

Dijon James Seales, a/k/a “DJ,” 28, of Philadelphia, is charged with conspiracy to possess with intent to distribute 50 grams or more of methamphetamine, possession with intent to distribute 50 grams or more of methamphetamine, possession with intent to distribute five grams or more of methamphetamine, being a felon in possession of a firearm, and possession of a firearm in furtherance of a drug trafficking crime. If convicted, Seales faces up to life in prison and a $25.5 million fine.

Lorenzo Dyrell Hickman, 32, of Philadelphia, is charged with conspiracy to possess with intent to distribute 50 grams or more of methamphetamine, conspiracy to possess with intent to distribute 500 grams or more of cocaine, and possession with intent to distribute more than 500 grams or more of cocaine. If convicted, Hickman faces a maximum penalty of life in prison and up to a $20 million fine.

Latrice Cherrrell Boler, 29, of Philadelphia, is charged with conspiracy to possess with intent to distribute 50 grams or more of methamphetamine. If convicted, Boler faces up to life in prison and to a $10 million fine.

Chaddis Demond McAfee, 36, of Philadelphia, is charged with possession with intent to distribute more than 500 grams of methamphetamine, being a felon in possession of a firearm, and possession of a firearm in furtherance of a drug trafficking crime. If convicted, McAfee faces up to life in prison and a $10.5 million fine.

Courtny Orlando Campbell, 27, of Philadelphia, is charged with possession with intent to distribute 50 grams or more of methamphetamine. If convicted, Campbell faces up to life in prison and a $10 million fine.

Danny L. Drake, 43, of Philadelphia, is charged with possession with intent to distribute five grams or more of methamphetamine. If convicted, Drake faces up to 40 years in prison and a $5 million fine.

Kevin Ashley Wells, a/k/a “Big 50,” 37, of Philadelphia, is charged with possession with intent to distribute five grams or more of methamphetamine. If convicted, Wells faces up to 40 years in prison and a $5 million fine.

Jimmie Terrell Harrison, 43, of Forest, is charged with being a felon in possession of a firearm. If convicted, Harrison faces up to 10 years in prison and a $250,000 fine.

Tray Beamon, 32, of Louisville, is charged with conspiracy to possess with intent to distribute 50 grams or more of methamphetamine and possession with intent to distribute 50 grams or more of methamphetamine. If convicted, Beamon faces up to life in prison and a $20 million fine.

“As a result of these arrests, Mississippi is a safer place to live, work and raise a family,” said MBN Director John Dowdy.

Jere T. Miles, special agent in charge of Homeland Security Investigations, oversees a five-state area of operations that includes Mississippi, Alabama, Arkansas, Louisiana and Tennessee.

“Methamphetamine has devastated countless communities due to the dramatic health and public safety consequences that typically accompany its introduction into an area,” Miles said.

Since Hurst has been in office, there have been several multi-level busts and operations that have targeted drug trafficking organizations and gangs. Many of those have been tied to Project EJECT, a comprehensive, multi-disciplinary initiative that stands for: Empower Jackson Expel Crime Together.

"The message is clear that we're not going to stop. we're going to work together across county lines, across district lines, and there's no one who can avoid us, who can hide from us, and we're going to make sure we put an end to this type of criminal activity in southern Mississippi," Hurst said.

Arraignments are scheduled for Friday before U.S. Magistrate Judge Keith Ball at 9 a.m. and before U.S. Magistrate Judge Linda R. Anderson at 9:30 a.m.

The Organized Crime Drug Enforcement Task Force is a result of a joint investigation by the U.S. Immigration and Customs Enforcement’s Homeland Security Investigations, the Drug Enforcement Administration and the MBN. Assisting agencies include the police departments of Philadelphia, Flowood, Carthage, Louisvill and Union; the Neshoba County, Scott County, Rankin County and Hinds County sheriff’s departments, Neshoba County District Attorney’s Office; Bureau of Alcohol, Tobacco, Firearms and Explosives; Mississippi Highway Patrol; U.S. Attorney's Office for the Southern District of Mississippi; and the U.S. Marshal Service. Assistant U.S. Attorney Erin Chalk is prosecuting the case.