Osteoporosis

Other | November 8, 2007

Now in its third edition,Osteoporosis, is the most comprehensive, authoritative reference on this disease. Written by renowned experts in the field, this two-volume reference is a must-have for academic and medical libraries, physicians, researchers, and any company involved in osteoporosis research and development. Worldwide, 200 million women between 60-80 suffer from osteoporosis and have a lifetime risk of fracture between 30 and 40 percent continuing to make osteoporosis a hot topic in medicine. This newest edition covers everything from basic anatomy and physiology to diagnosis, management and treatment in a field where direct care costs for osteoporitic fractures in the U.S. reach up to $18 billion each year.

NEW TO THIS EDITION:*Recognizes the critical importance of the Wnt signaling pathway for bone health*Incorporates new chapters on osteocytes, phosphatonins, mouse genetics, and CNS and bone*Examines essential updates on estrogen prevention and treatment and the recent results from the WHI*Discusses the controversial topics of screening and clinical trial design for drug registration*Includes essential updates on therapeutic uses of calcium, vitamin D, SERMS, bisphosphonates, and parathyroid hormone* Offers critical reviews of reproductive and hormonal risk factors, ethnicity, nutrition, therapeutics, management, and economics comprising a tremendous wealth of knowledge in a single source not found elsewhere

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Now in its third edition,Osteoporosis, is the most comprehensive, authoritative reference on this disease. Written by renowned experts in the field, this two-volume reference is a must-have for academic and medical libraries, physicians, researchers, and any company involved in osteoporosis research and development. Worldwide, 200 mill...

Dr. Rosen is Professor and Senior Scientists at The Jackson Laboratory, Bar Harbor, Maine, where his group studies the role of insulin-like growth factors on bone and the genetics of osteoporosis in inbred strains of mice. In 2007 he joined the Maine Medical Center Research Institute in Scarborough, Maine. He is also the former Directo...

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Table of Contents

IntroductionThe Bone Organ System: Form and FunctionThe Nature of OsteoporosisThe Economics of OsteoporosisReflections on OsteoporosisSkeletal Heterogeneity and the Purposes of Bone Remodeling: Implications for theUnderstanding of OsteoporosisBasic Science/Bone BiologyOsteoblast BiologyOsteoclast BiologyOsteocytesThe Regulatory Role of Matrix Proteins in Mineralization of BoneDevelopment of the SkeletonMouse Genetics as a Tool to Study Bone Development and PhysiologyParathyroid Hormone and Parathyroid Hormone-Related ProteinVitamin D: Biology, Action, and Clinical ImplicationsRegulation of Bone Cell Function by EstrogensAndrogens and Skeletal Biology: Basic MechanismsPhosphatoninsWnt Signaling in BoneCytokines and Bone RemodelingSkeletal Growth FactorsIntercellular Communication During Bone RemodelingStructural and BiomechanicsSkeletal Development: Mechanical Consequences of Growth, Aging and DiseaseInhibition of Osteoporosis by Biophysical InterventionBiomechanics of Age-Related FracturesBone QualityEpidemiology & Risk FactorsEpidemiologic Methods in Studies of OsteoporosisRace, Ethnicity and OsteoporosisThe Study of Osteoporotic Fractures (SOF): Major Findings and ContributionsBone Mineral Acquisition in Utero and During Infancy and ChildhoodBone Acquisition in AdolescenceGenetic Determinants of OsteoporosisNutrition and Risk for OsteoporosisPhysical Activity in Prevention of Osteoporosis and Associated FracturesPremenopausal Reproductive and Hormonal Characteristics and the Risk for OsteoporosisNon-Skeletal Risk Factors for Osteoporosis and FracturesFalls as Risk Factors for FractureAssessment of Fracture RiskOutcomes of Osteoporotic FracturesPathophysiologyLocal and Systemic Factors in the Pathogenesis of OsteoporosisAnimal Models for OsteoporosisEstrogen, Bone Homeostasis and OsteoporosisPostmenopausal Osteoporosis: How the Hormonal Changes of Menopause Cause Bone LossOsteoporosis in Men: Epidemiology, Pathophysiology, and Clinical CharacterizationOsteoporosis in Childhood and AdolescenceGlucocorticoid-Induced OsteoporosisAdult Scoliosis, Degenerative Disease, and BMD: a Sub-Segmental Analytic ApproachMechanisms of Immobilization-induced Bone LossLeptin-Dependent Regulation of Bone MassThyroid Hormone and the SkeletonOsteoporosis in Gastrointestinal, Pancreatic, and Hepatic DiseaseThe Skeletal Actions of Parathyroid Hormone in Primary Hyperparathyroidism and in OsteoporosisOsteogenesis Imperfecta and Other Defects of Bone Development as Occasional Causes of Adult OsteoporosisOsteoporosis Associated with Illnesses and MedicationsTransplantation OsteoporosisOsteoporosis Associated with Cancer TherapyOsteoporosis Associated with PregnancyOsteoporosis Associated with Rheumatologic DiseaseOral Bone Loss and Systemic Osteopenia: Potential Treatment and RisksLocalized OsteoporosisEvaluation and ManagementEvaluation of the Patient with Osteoporosis or at Risk for OsteoporosisWho Should be Screened: Who Should be Treated?Radiology of OsteoporosisClinical Use of Bone DensitometryBiochemical Markers of Bone Turnover in OsteoporosisThe Conundrum of Compliance and Persistence with Oral Bisphosphonates for Postmenopausal OsteoporosisAn Orthopedic Perspective of OsteoporosisLessons from Bone Histomorphometry on the Mechanism of Action of Osteoporosis DrugsPharmacology and TherapeuticsDesign Considerations for Clinical Investigations of OsteoporosisRegulatory Considerations for the Design and Conduct of Osteoporosis Registration TrialsEvidence-Based Osteoporosis CareThe Role of Calcium in the Treatment of OsteoporosisVitamin D and its Metabolites and Analogs in the Management of OsteoporosisEstrogen Therapy: Prevention and Treatment of OsteoporosisEstrogen Analogues: Selective Estrogen Receptor Modulators (SERMs) and PhytoestrogensBisphosphonates: Pharmacology and Use in the Treatment of OsteoporosisCalcitonin in OsteoporosisStrontium Therapy for OsteoporosisAndrogensTreatment with PTH PeptidesGrowth Hormone and Insulin-like Growth Factors: Potential Applications and Limitations in the Management of OsteoporosisNew approaches to Osteoporosis Therapeutics