Leighton played Jane Mancini's troubled sister, Sydney Andrews, on "Melrose Place." Off-screen, Leighton found love with costar Doug Savant -- a.k.a. Matt Fielding -- and the two married and had two children together. After leaving "Melrose," Leighton stopped by shows such as Beverly Hills, 90210," "Boston Legal," "CSI: Miami" and "Law & Order: SVU." Get ready for the motherload -- Syd will be back on the new CW reboot of "Melrose" as the new landlady.

Jack Wagner played the scheming Dr. Peter Burns on "Melrose Place." No deed was too evil for Burns; he even tried to kill Amanda, an... Show More »

Jack Wagner played the scheming Dr. Peter Burns on "Melrose Place." No deed was too evil for Burns; he even tried to kill Amanda, and he was in love with her! After "Melrose," Wagner stuck with the soaps, playing a sea captain (yes, seriously) on "The Bold and the Beautiful." « Less

3/15

Doug Savant:

Doug Savant played one of network TV's first openly gay characters, social worker Matt Fielding, on "Melrose Place." After leav... Show More »

Doug Savant played one of network TV's first openly gay characters, social worker Matt Fielding, on "Melrose Place." After leaving "Melrose," Savant appeared on "24." He now plays Tom, husband of Lynette Scavo (Felicity Huffman), on "Desperate Housewives." « Less

4/15

Courtney Thorne-Smith:

Courtney Thorne-Smith's Allison Parker may have looked like the quintessential girl-next-door, but she had her share ... Show More »

Courtney Thorne-Smith's Allison Parker may have looked like the quintessential girl-next-door, but she had her share of troubles. Allison had a stalker who killed himself, was molested as a child and had substance abuse issues. After leaving "Melrose," Thorne-Smith played Georgia Thomas on "Ally McBeal" for three seasons. Thorne-Smith has been open about her struggle with an eating disorder during her time on "Ally McBeal." From 2001 to 2008, she played Cheryl on "According to Jim," opposite Jim Belushi. She is also a published novelist. « Less

5/15

Heather Locklear:

Locklear spent six years playing strong and sexy art director Amanda Woodward on "Melrose Place." Amanda rose through the ranks... Show More »

Locklear spent six years playing strong and sexy art director Amanda Woodward on "Melrose Place." Amanda rose through the ranks at her workplace and moved through the show's men effortlessly. Post-"Melrose," Locklear had three years on "Spin City," a stint on "LAX" and a helping of off-screen drama. After she divorced her second husband, Bon Jovi guitarist Richie Sambora, he started dating her friend Denise Richards. Last July, Locklear went to an Arizona facility to deal with anxiety and depression. In September, she was arrested in Santa Barbara County after a report that she'd been driving erratically. She's was booked for driving under the influence, but the charges were dropped in January 2009.

Now, in the same vein as the "Beverly Hills, 90210" alum, Locklear will reprise her juicy role as Amanda on "Melrose Place" 2.0. « Less

6/15

Andrew Shue:

Andrew Shue played the infamous Billy Campbell, the only one immune to the drama at Melrose Place. He dated a slew of women and almo... Show More »

Andrew Shue played the infamous Billy Campbell, the only one immune to the drama at Melrose Place. He dated a slew of women and almost married Allison but ended up with Jennifer Mancini (Alyssa Milano) instead. Since "Melrose," Shue has done disappointingly little acting work. He wrote, produced and acted in "Gracie" with his sister, Elisabeth Shue, but that's about it. Maybe he was too recognizable as Billy? Believe it or not, his most recent venture is a social networking site called CafeMom, billed as "a place for moms and moms-to-be to connect with one another." « Less

7/15

Alyssa Milano:

Alyssa Milano's character, Jennifer Mancini, was cut from the same cloth as her mischievous brother, Michael. After "Melrose,... Show More »

Alyssa Milano's character, Jennifer Mancini, was cut from the same cloth as her mischievous brother, Michael. After "Melrose," Milano spent eight years starring on the hit series "Charmed." She recently appeared on the wacky comedy "My Name Is Earl." Beyond the small screen, Milano recently released her first book, "Safe at Home: Confessions of a Baseball Fanatic." « Less

8/15

Rob Estes:

Rob Estes' path on "Melrose Place" was a peculiar one: He played two characters during his tenure. Estes came on for some guest s... Show More »

Rob Estes' path on "Melrose Place" was a peculiar one: He played two characters during his tenure. Estes came on for some guest spots as Michael Mancini's pal Sam. He later returned as hunky restaurateur Kyle McBride. Estes' career continued to flourish post-"Melrose." He enjoyed lengthy stints on "Suddenly Susan," "Women's Murder Club" and most recently Harry Wilson, principal at West Beverly High on the new "90210." « Less

9/15

Kristin Davis:

Kristin Davis played the impossibly unlikable Brooke Armstrong Campbell on the series. In true "Melrose" fashion, her character wa... Show More »

Kristin Davis played the impossibly unlikable Brooke Armstrong Campbell on the series. In true "Melrose" fashion, her character was killed off ever so dramatically: She drowned in the courtyard pool. After "Melrose," Davis landed the dream role of prim and proper Charlotte York on the hit HBO series "Sex and the City," where she stayed from 1998 until 2004. Davis recently costarred in the 2008 hit "Sex and the City" movie and joins Vince Vaughn and Jason Bateman in the comedy "Couples Retreat." « Less

10/15

Kelly Rutherford:

Kelly Rutherford played reformed prostitute Megan Lewis Mancini on "Melrose Place." She currently plays another character with ... Show More »

Kelly Rutherford played reformed prostitute Megan Lewis Mancini on "Melrose Place." She currently plays another character with a hidden past: Lily van der Woodsen on the CWs hit series "Gossip Girl." « Less

11/15

Daphne Zuniga:

Zuniga played tough-as-nails photographer Jo Reynolds. Reynolds always had a thing for bad boys, a weakness that led to some very ... Show More »

Zuniga played tough-as-nails photographer Jo Reynolds. Reynolds always had a thing for bad boys, a weakness that led to some very scary, sloppy relationships. And she wasn't above fist-fighting her foes. Most recently, Zuniga has appeared on "One Tree Hill" and voiced the character of Princess Vespa on "Spaceballs: The Animated Series." She will appear in at least two episodes of the new "Melrose Place" this season. « Less

12/15

Thomas Calabro:

As the two-faced Dr. Michael Mancini, Calabro was the only original cast member to stay on "Melrose Place" through its seven-year... Show More »

As the two-faced Dr. Michael Mancini, Calabro was the only original cast member to stay on "Melrose Place" through its seven-year run. After guest stints on shows such as "Touched by an Angel," "Without a Trace" and "Greek," Calabro will return to the new "Melrose Place" to play father to David Breck (Shaun Sipos), reportedly one of the new resident bad boys on the block. « Less

13/15

Josie Bissett:

Bissett spent seven years playing Jane Mancini -- one of the show's original fixtures Mancini is known for opening her own cl... Show More »

Bissett spent seven years playing Jane Mancini -- one of the show's original fixtures Mancini is known for opening her own clothing store and for her awesome pool fight with Sydney. Bissett now plays Kathleen Bowman on ABC Family's "The Secret Life of the American Teenager." Bissett is also set to reprise her role as Jane on the "Melrose" reboot. « Less

14/15

Amy Locane:

Locane played Southern-bred aspiring actress Sandy Louise Harling on "Melrose Place." Since then she's appeared in "Prefontaine"... Show More »

Locane played Southern-bred aspiring actress Sandy Louise Harling on "Melrose Place." Since then she's appeared in "Prefontaine" and on "Touched by an Angel," but she never became a household name. « Less

15/15

Vanessa A. Williams:

Rhonda Blair, played by Williams, was one of the rare nice girls in the compound. Blair, the only black person at Melrose Pl... Show More »

Rhonda Blair, played by Williams, was one of the rare nice girls in the compound. Blair, the only black person at Melrose Place, was an aspiring dancer from South L.A. Since "Melrose," Williams has kept busy, appearing on "Chicago Hope," "The Steve Harvey Show" and most recently the TV series "Soul Food." She recently appeared in the Lifetime movie called "Flirting With Forty" alongside fellow "Melrose" alum Heather Locklear.