Yuzhno-Sakhalinsk (Russian: Ю́жно-Сахали́нск) is a city and the administrative center of Sakhalin Oblast, Russia. It was called Vladimirovka from 1882 to 1905, then Toyohara from 1905 to 1946. Population: 192 780 (2015).

Yuzhno-Sakhalinsk is the administrative center of the oblast. Within the framework of administrative divisions, it is, together with ten rural localities, incorporated as the city of oblast significance of Yuzhno-Sakhalinsk—an administrative unit with the status equal to that of the districts. As amunicipal division, the city of oblast significance of Yuzhno-Sakhalinsk is incorporated as Yuzhno-Sakhalinsk Urban Okrug.

The city is served by the Yuzhno-Sakhalinsk Airport. The city is also the hub for the island's narrow gauge railway network, the Sakhalin Railway, built under the Japanese administration in the early 20th century.