Prepared in the context of cooperation between the International Programme on Chemical Safety & the Commission of the European Communities (C) IPCS CEC 1994. No modifications to the International version have been made except to add the OSHA PELs, NIOSH RELs and NIOSH IDLH values.

2,4-TOLUENE DIISOCYANATE

ICSC: 0339

I

CHEMICAL DANGERS: The substance may polymerize under the influence of bases, tertiary amines and acyl chlorides with fire or explosion hazard. On combustion, forms toxic vapours and gases including nitrogen oxides and isocyanates. Reacts readily with water , acids and alcohols causing pressure rise explosion hazard.

ROUTES OF EXPOSURE: The substance can be absorbed into the body by inhalation of its vapour and by inhalation of its aerosol and by ingestion.

INHALATION RISK: A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20°C.

EFFECTS OF SHORT-TERM EXPOSURE: The substance, the vapour of this substance and the aerosol is irritating to the eyes , the skin and the respiratory tract . Inhalation of the vapour may cause asthma-like reactions. Inhalation of the vapour may cause chemical bronchitis, pneumonitis and lung oedema. Exposure far above the OEL may result in death. The effects may be delayed. Medical observation is indicated.

EFFECTS OF LONG-TERM OR REPEATED EXPOSURE: Repeated or prolonged contact may cause skin sensitization. Repeated or prolonged inhalation exposure may cause asthma. This substance is possibly carcinogenic to humans.

ENVIRONMENTAL DATA

N O T E S

Technical toluene diisocyanate is a mixture of 2,4- and 2,6-isomers (80:20), TDI is a common name. Depending on the degree of exposure, periodic medical examination is suggested. Immediate administration of an appropriate inhalation therapy by a doctor or a person authorized by him/her, should be considered. The symptoms of asthma often do not become manifest until a few hours have passed and they are aggravated by physical effort. Rest and medical observation are therefore essential. Anyone who has shown symptoms of asthma due to this substance should avoid all further contact with this substance. The odour warning when the exposure limit value is exceeded is insufficient. Card has been partly updated in April 2005. See sections Occupational Exposure Limits, EU classification, Emergency Response.

ADDITIONAL INFORMATION

ICSC: 0339

2,4-TOLUENE DIISOCYANATE

(C) IPCS, CEC, 1994

IMPORTANT LEGAL NOTICE:

Neither NIOSH, the CEC or the IPCS nor any person acting on behalf of NIOSH, the CEC or the IPCS is responsible for the use which might be made of this information. This card contains the collective views of the IPCS Peer Review Committee and may not reflect in all cases all the detailed requirements included in national legislation on the subject. The user should verify compliance of the cards with the relevant legislation in the country of use. The only modifications made to produce the U.S. version is inclusion of the OSHA PELs, NIOSH RELs and NIOSH IDLH values.