We are doing a greenfield NSX deployment at a site. We are following the VVD so we have a 4-node management cluster with 2 vCenters, a Computer vCenter and a Management vCenter. We would like to put both of the vCenters in HA mode. Will the NSX manager or any other appliances that register with vCenter have any issues during failover? I have not seen that to be the case. We also using Ephemeral VDS ports for the vCenter nics just in case we have issues and need to do some things with the ESXi host.

However, in the VMware validated design, vCenter HA is not mentioned. So that got me thinking. Thank you very much.

We have HA enabled on our vCenter with NSX and not had any issues (apart from those mentioned in the change logs in the past duplicate vteps etc). VMware also went through the design and we have had a health check inc NSX and nothing was flagged up for nsx

We had this many times in the past, this has supposedly been fixed. Its basically vcenter getting rebooted while the nsx manager is up and then it recreating them. solution is to shut the nsx manager down before the vcenter but this is not possible in a ha situation. The issue has been resolved in the later versions of nsx if you dare upgrade