TRAnsient Pockets in Proteins

Analysis of transient binding pockets in proteins

The TRAPP webserver, and the downloadable command line version, is intended to aid the discovery of ligands that bind in transient subpockets in proteins. Please note modifications of the server in our changes document.

The TRAPP webserver offers

a range of tools to explore binding site motions ranging from local side chain fluctuations to global backbone motions

analysis of the binding site dynamics in simulated protein motion trajectories or trajectories provided by the user

a tool for tracking, analysis and visualization of protein cavity dynamics in an ensemble of protein structures or in protein trajectories

detection of transient pockets and subpockets that may appear due to protein motion

combined analysis of the protein sequence conservation and the variations of the physicochemical properties of a binding pocket