..Familial colorectal cancer has been linked to chromosome 7q31 by multiple affected relative pair studies. The MET proto-oncogene which resides in this chromosomal region is considered a candidate for genetic susceptibility...

Polymorphisms in NF-kappaB inhibitors and risk of epithelial ovarian cancer

..Two trinucleotide repeat polymorphisms have been described in exon 1 of the androgen receptor (AR) gene that may affect its function. Previous studies of ovarian cancer and AR repeat polymorphisms have been inconsistent...

..This analysis shows the importance of consortia, like the OCAC, in either confirming or refuting the validity of putative findings in studies with smaller sample sizes. (Cancer Epidemiol Biomarkers Prev 2008;17(12):3567-72)...

..0; 95% CI = 0.7-1.4). These findings support the hypothesis that obesity is an important risk factor of ovarian cancer among African-Americans and Whites and also suggest that height may be a risk factor specific to African-Americans...

..It has been suggested that the 6A allele of the type I TGFbeta receptor (TGFbetaR1) polyalanine repeat tract polymorphism may increase susceptibility to various types of cancer including ovarian cancer...

..5002G > A genotype and EGA was not evident. These findings suggest that nonsynonymous polymorphisms in M6P/IGF2R may contribute to the risks of EGA and noncardia adenocarcinomas. Larger studies are required to confirm these findings...

..Findings suggest that associations between ovarian cancer and reproductive characteristics vary by menopausal status. Additional research is needed to further elucidate risk factors for postmenopausal disease...

Recreational physical activity and ovarian cancer risk and survival

Patricia G MoormanCancer Prevention, Detection and Control Research Program, Department of Community and Family Medicine, Duke University Medical Center, Durham, NC 27705, USAAnn Epidemiol 21:178-87. 2011

..We examined associations between self-reported physical activity and ovarian cancer risk and survival in a population-based, case-control study in North Carolina...

Factors associated with African Americans' enrollment in a national cancer genetics registry

..In this study, we evaluated the association between maternal antibiotic use and LBW and examined the potential role of altered DNA methylation that controls growth regulatory imprinted genes in these associations...

Association of single nucleotide polymorphisms in glycosylation genes with risk of epithelial ovarian cancer

..10 frequency; odds ratio, 0.07; P = 0.01) compared with the most common haplotype (0.39 frequency). These results suggest that genetic polymorphisms in the glycoslyation process may be novel risk factors for ovarian cancer...

..At least 7 models for estimating the probabilities of having a mutation are used widely in clinical and scientific activities; however, the merits and limitations of these models are not fully understood...

..Interventions with modifiable factors such as multivitamin intake may reduce risk...

Oral contraceptive use, reproductive history, and risk of epithelial ovarian cancer in women with and without endometriosis

Francesmary ModugnoDepartment of Epidemiology, Graduate School of Public Health, University of Pittsburgh, and University of Pittsburgh Cancer Institute, Pittsburgh, PA 15261, USAAm J Obstet Gynecol 191:733-40. 2004

..We investigated whether the odds ratios for ovarian cancer that were associated with oral contraceptive use, childbearing, hysterectomy, and tubal ligation differ among women with and without endometriosis...

Characterization of BRCA1 and BRCA2 mutations in a large United States sample

..Existing studies have focused on Ashkenazi Jews (AJ) or on families from outside the United States. In this article, we consider the US population using the largest US-based cohort to date of both AJ and non-AJ families...

..Within this application, we propose to take advantage of our expertise and resources to ascertain registrants by augmenting referral services and by piloting the selective use of our unique registries. ..