New viral diseases are emerging continuously. Viruses adapt to new environments at astounding rates. Genetic variability of viruses jeopardizes vaccine efficacy. For many viruses mutants resistant to antiviral agents or host immune responses arise readily, for example, with HIV and influenza. These variations are all of utmost importance for human... more...

RNA viruses, by virtue of their high mutation rates and large population sizes, from complex mutant distributions termed viral quasispecies. Studies collected here address connections between theoretical quasispecies and real virus quasispecies, and the biological implications of the quasispecies structure of RNA viruses and other simple replicons. more...

One of the most profound events in sixteenth-century North America was a ferocious battle between the Spanish army of Hernando de Soto and a larger force of Indian warriors under the leadership of a feared chieftain named Tascalusa. The site of this battle was a small fortified border town within an Indian province known as Mabila. Although the... more...