Try this: delete epson c43sx drivers then reinstall them then go to the Epson web site and look for an updated driver, if that does not work take the whole cartridge harness out, under the harness you will see a contact board and you will see another one on the printer, get cleaning solvent and a cotton buds, dip cotton bud into the cleaning solvent, turn cotton buds sideways and clean the contact boards on both the cartridge and the printer, clean until and refresh cotton buds until you get a a clean cotton bud tip, let it sit for 5 to 10 minutes, reinstall the harness and try again, if that does not work you could have a main board problem contact Epson.

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I'm assuming that you are probably using Non-Epson Ink Cartridges, because those are what normally cause that problem, with a printer not recognizing an installed ink cartridge. Unfortunately, there is no way to make your Epson Printer use or accept that Non-Epson Ink Cartridge, if it cannot actually recognize it. Its even possible that some Generic or Third-Party brands, may not always be recognized by the newer models of Epson Printers, because of the inexpensive [cheap] and or incompatable Electrical Chips that are mounted on the actual ink cartridge. Sometimes you will even get Error Messages up on your Monitors screen, telling you that you are actually using a Non-Epson Ink Cartridge, or that your printer cannot recognize the cartridge that you installed. Sometimes the Ink Level Indicator, on your Status Monitor, will not show an actual ink level, but may indicate a cartridge error or problem instead. Not all Generic or Third-Party ink & ink cartridges are made the same and none of them actually contain the right formulation of ink, for the Epson Printers [formula is patented by Epson Company]. Some are probably close and seem to be better than others, but some simply can clog-up or even damage the Printhead Assemblies on Epson Printers, or simply won't be accepted at all. Epson Ink Jet Printers are one of the few printers on the market that seem to have so many problems with non-manufactors inks, especially the newer models made in the last couple of years. Its because the Epson Printers use a completely different printhead inking system than most other brands of printers. Most, if not all of the other manufactors, use thermal or bubble jetprint heads and because the other brands use a totally different system, they don't seem to have as many problems using refilled inks or non-manufactor's ink cartridges. Printer manufacters do not make available their ink formulation and in most cases, the formulation is patented. Any difference in the ink formulation can actually cause clogging in the small printhead nozzles or damage other critical components. One individual printhead nozzle is so tiny, that it will not accept a human hair, so you can see why they can get clogged so easily, or even why the nozzles can be so easily damaged...Even if you were actually using a New-Epson Ink Cartridge, its always possible that you got a bad cartridge. At this point, the only thing I can suggest is that you try a different New-Epson Ink Cartridge, or at the very least, a different brand of Non-Epson Ink Cartridges and see if that helps.

ALL…. Epson & Brother Requires Genuine Epson Cartridges. !!!!!!!! That sounds like your problem. Replace with new and Originial......... In Purchasing Epson's CX 5400, CX4600, & CX7400 and more, I found out that Epson does not like Generic Printer Cartridges.I also Purchased a Brother.That also does not like Generic Print Cartridges.Color that should be Yellow, will turn out Green, Blue Brown, etc. These printers have a CHIPthat will detect if it is Generic or Genuine.When they see it’s Generic Cartridges, it will print lines thru the words, stripes across the picture and also do a mix match with the colors, even will not recognize generic cartridges....!That's what these Companies do., so they can keep selling the ink cartridges.Some Printers, are able to use Generic, and some are refillable.Some you can refill them up yourself and I heard, quite MESSY.

So I learned, thru trial and error, that you must use the ORIGINAL Genuine Cartridges for these PRINTERS.Some people say some models work fine compatible, but not mine.......I had to replace the printer, but Epson, Lexmark & Brothers are always on sale.My Brother & Epson cost me $50.00 with Rebate.Don’t waste too much ink in cleaning it. It can be costly.

This is the only advice I can give you.If you find this helpful, pls rate me.

t is possible that the ink cartridges in your printer (especially
applicable if you are using refilled or compatible carts) can not be
read by the printer. Some compatible cartridges have a failure rate as
high as 30% and so it is very possible that the machine either does not
see the cartridges or can not read them.

Replace the cartridges
with genuine Epson ones and try again. The genuine ink will also help
to clear any hardening cheap ink in the print head.

t is possible that the ink cartridges in your printer (especially
applicable if you are using refilled or compatible carts) can not be
read by the printer. Some compatible cartridges have a failure rate as
high as 30% and so it is very possible that the machine either does not
see the cartridges or can not read them.

Replace the cartridges
with genuine Epson ones and try again. The genuine ink will also help
to clear any hardening cheap ink in the print head.

It is possible that the ink cartridges in your printer (especially applicable if you are using refilled or compatible carts) can not be read by the printer. Some compatible cartridges have a failure rate as high as 30% and so it is very possible that the machine either does not see the cartridges or can not read them.

Replace the cartridges with genuine Epson ones and try again. The genuine ink will also help to clear any hardening cheap ink in the print head.

I have a similar Printer. And similar problems crop up.
Have tried cleaning the contact terminals in the cartridge slot?
(You will notice a small PCB on the TO 38 Black ink cartridge) This terminal sends data to the Printer and then to the Status Monitor screen.If these contact terminals are dirty, or if your cartridge is not a Genuine Epson TO 38 cartridge but a generic alternate cartridge, then the PCB contact configuration will be different and so will send wrong data to the Printer Logic Processor.
My suggestions are
1. Make sure yours is a Genuine Epson TO 38 cartridge
2. Clean the contacts in the Cartridge compartment.
99% your problem should be solved.
Pravin Gupta, India guptapravin@hotmail.com