V(D)J recombination occurs in lymphoid precursors to allow their maturation but

V(D)J recombination occurs in lymphoid precursors to allow their maturation but also induces DNA damage. from both the T-lineage and the B-lineage. Restores the Development of Miz-1-Deficient αβ-Lineage Pre-T and Pro-B Cells. To determine whether the developmental block and increased apoptosis seen in Miz-1-deficient pre-T cells and pro-B cells are related to increased p53 signaling we generated p53-deficient Miz-1ΔPOZ mice. We found GW 501516 significant increases in both the percentage and complete quantity of GW 501516 DN3b and DN4 cells in Miz-1ΔPOZ × Trp53?/? mice as well as almost GW 501516 completely restored thymic cellularity compared with Miz-1ΔPOZ mice (Fig.