UDP-Glucose 6-Dehydrogenase (UGDH) ELISA Kits

The protein encoded by UGDH converts UDP-glucose to UDP-glucuronate and thereby participates in the biosynthesis of glycosaminoglycans such as hyaluronan, chondroitin sulfate, and heparan sulfate. Additionally we are shipping UGDH Antibodies (70) and UGDH Proteins (16) and many more products for this protein.

More ELISA Kits for UGDH Interaction Partners

Human UDP-Glucose 6-Dehydrogenase (UGDH) interaction partners

UGDH protein level in osteoarthritis cartilage was much lower than in control cartilage.

UGDH displays hysteresis because of a slow isomerization from an inactive state (E*) to an active state (E). We show that the structure of E* constrains UGDH in a conformation that favors feedback inhibition at physiological pH.

Kinetic analysis of wild-type UGDH and hexamer T325A showed that upon increasing enzyme concentration, which favors the hexameric species, activity was decreased and exhibited cooperativity. Cooperative kinetics was not observed in obligate dimer T325D.

Mammalian UGDH displays hysteresis (observed as a lag (show STMN1 ELISA Kits) in progress curves), indicating that the enzyme undergoes a slow transition from an inactive to an active state. Human UGDH is sensitive to product inhibition during the lag (show STMN1 ELISA Kits).

both missense mutations significantly reducing the ability of UGDH to provide precursors for cardiac cushion formation, which is essential to subsequent valve formation.

UGDH Antigen Profile

Antigen Summary

The protein encoded by this gene converts UDP-glucose to UDP-glucuronate and thereby participates in the biosynthesis of glycosaminoglycans such as hyaluronan, chondroitin sulfate, and heparan sulfate. These glycosylated compounds are common components of the extracellular matrix and likely play roles in signal transduction, cell migration, and cancer growth and metastasis. The expression of this gene is up-regulated by transforming growth factor beta and down-regulated by hypoxia. Alternative splicing results in multiple transcript variants.