GP1BB

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GP1BB

A gene on chromosome 22q11.21-q11.23|22q11.21 that encodes the beta subunit of the Ib-V-IX system of platelet surface membrane glycoproteins, which comprise the von Willebrand factor receptor and mediate adhesion of platelets to injured vascular surfaces with circulation, a critical event in haemostasis. The beta unit contributes to surface expression of the receptor and participates in transmembrane signalling through phosphorylation of its intracellular domain.

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