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You should check with your doctor first.Using nortriptyline together with drugs like OTC Unisom Sleep Gels (diphenhydramine) may increase side effects such as drowsiness, blurred vision, dry mouth, heat intolerance, flushing, decreased sweating, difficulty urinating, abdominal cramping, constipation, rapid heart beats, confusion, and memory problems. Side effects may be more likely to occur in the elderly or those with serious health problems.