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Abstract

In today's technology, even leading medical institutions diagnose their cardiac patients through ECG recordings obtained at healthcare organizations (HCO), which are costly to obtain and may miss significant clinically-relevant information. Existing long-term patient monitoring systems (e.g., Holter monitors) provide limited information about the evolution of deadly cardiac conditions and lack interactivity in case there is a sudden degradation in the patient's health condition. A standardized and scalable system does not currently exist to monitor an expanding set of patient vitals that a doctor can prescribe to monitor. The design of such a system will translate to significant healthcare savings as well as drastic improvements in diagnostic accuracy. In this chapter, we will propose a concept system for real-time remote cardiac health monitoring, based on available and emerging technologies today. We will analyze the details of such a system from acquisition to visualization of medical data.

Currently, there are no suitable methods to assess and predict the risk of CVD and chronic heart failure in real time to enable effective therapeutic intervention (Lin, Zhang, & Zhang, 2013; Jiao, et al., 2014; Gonzales, White, & Safranek, 2014). Mechanisms that are involved in the development of CVD are complex and involve a variety of interrelated processes including changes in blood cholesterol, lipid metabolism, inflammation and oxidative stress. Pathological role of reactive oxygen species (ROS) in the development of CVD, especially in conditions related to cardiac ischemia and chronic heart failure is well studied (Nojiri, et al., 2006; Otani, 2004; Searles, 2002; Singh, 1995; Tsutsui, 2001). Among ROS species, superoxide radicals and nitric oxide (NO) have both been identified as important parameters in the pathophysiological alterations in myocardial and vascular function (Kundu, 2012; Salamifar & Lai, 2013). Other studies have related cardiac proteins including cardiac troponins (cTn), myoglobin (MYO), b-type natriuretic peptide (BNP) and C-reactive protein (CRP) with the onset of cardiac infarction (Wojciechowska, et al., 2014).

The proposed system in Figure 1 will enable physicians to monitor patients and have automatic alarm providing feedback on patient long-term health status. This monitoring can be continuous in patients with high risk for life-threatening events, or periodic with a recording frequency depending on disease severity. This system is capable of monitoring ECG-related parameters using commercially available ECG patches, as well as multiple other aforementioned bio-markers of a patient via custom bio-sensors in real-time. Sensory recordings of the patient will be transmitted from the patient’s house (or any remote location) to the datacenter of the HCO in real-time in a secure fashion using well established encryption mechanisms (NIST:FIPS-197, 2001). Combining ECG monitoring parameters with such biomarkers improves the utility of the monitoring system to far beyond what is currently achievale with ECG-only monitoring or single-biomarker monitoring (e.g., Glucose (Sensys Medical)). This technology will be disruptive because it has the potential to shift the paradigm of patient management in the US healthcare system.