Open Source Malaria (OSM, pronounced "''awesome''") is aimed at finding new medicines for malaria using strictly open source principles, embodied in the [[Open_Source_Research | 6 Laws of Open Research]].

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[http://opensourcemalaria.org/ Open Source Malaria (OSM)] is aimed at finding new medicines for malaria using open source principles, embodied in the [[Open_Source_Research | 6 Laws of Open Research]]. At the moment the majority of work involves the synthesis of analogs of compounds identified by big pharma, with the aim of improving their potency while making the molecules more "druggable", what is known as a "hit-to-lead" campaign.

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This wiki describes where the project is up to, and summaries of relevant data. For other aspects of the project, see the main [http://opensourcemalaria.org/# Project Landing Page].

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Medicinal chemists should head to the [[OpenSourceMalaria:Story_so_far|project summary]], then the [[OpenSourceMalaria:Compound_Series| individual compound series page]]. The most active series at the moment is [[OpenSourceMalaria:Triazolopyrazine_(TP)_Series|Series 4]].

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If you would like to improve these wiki pages, you will need to get an OpenWetWare account ([[OpenWetWare:How_to_join |which is easy]]).

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For a good general overview, see the '''April 2014 newsletter''', which can be downloaded as a PDF [http://malaria.ourexperiment.org/data/files/10840/OSM%20Newsletter%20April%202014.pdf here]. Answers to many common questions can be found in the [[OpenSourceMalaria:FAQ | FAQ]] page

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== About the Malaria Project ==

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This wiki describes where the project is up to, and archives some data and loose ends. For everything else about the project, see the main [http://opensourcemalaria.org/# Project Landing Page]. For a list of current to do items that can be filtered by type and series, see the [https://github.com/OpenSourceMalaria/OSM_To_Do_List/issues?state=open To Do List].

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A human-friendly summary of the science to date can be found in [[OpenSourceMalaria:Story_so_far|'''The Story So Far''']].

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==About OSM, What's Needed and how to Contact==

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A description of what open research is can be found in the [[Open_Source_Research|'''Open Research Page''']]

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The background to the project may be found in the [[OpenSourceMalaria:Story_so_far|Story so Far]]. Publications from the project and other outputs are in the [[OpenSourceMalaria:Links|'''Links''']] page, along with media about the project.

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Aggregated data on various branches of the project so far can be found on the [[OpenSourceMalaria:Compound_Series|Compound Series Page]].

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The main resources needed in the OSM project are '''experimental input''', particularly [https://github.com/OpenSourceMalaria/OSM_To_Do_List/issues?labels=Being+Synthesised+Now&page=1&state=open chemical compound synthesis] and help with chem/bioinformatics. Anyone can make compounds, get them tested and contribute data. You don't have to be a research scientist - maybe you're an undergrad doing a lab.

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== What's Happening and What's Needed ==

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If you have no access to a lab, there are a number of important other things needed, labelled as such on the To Do List, such as things to do with [https://github.com/OpenSourceMalaria/OSM_To_Do_List/issues?labels=Writing&milestone=&page=1&state=open writing] or [https://github.com/OpenSourceMalaria/OSM_To_Do_List/issues?labels=PR&milestone=&page=1&state=open PR] to help spread the word.

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Daily updates (including the To Do list) can be accessed through [http://opensourcemalaria.org/# the project's main hub].

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Ideally everything happens in the public domain through any of the ways shown on the [http://opensourcemalaria.org/# Landing Page] but you can in the last resort contact the consortium using opensourcemalaria@gmail.com

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At the moment (July 2013) there is most activity on [[OpenSourceMalaria:GSK_Amino-thienopyrimidine_Series|'''Series 2''']], with the raw data in [http://malaria.ourexperiment.org/aminotpseries this lab notebook].

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==Help Maintain this Wiki==

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The main resources needed in the OSM project are '''experimental input''', particularly chemical compound synthesis and help with chem/bioinformatics. Anyone can make compounds, get them tested and contribute data. You don't have to be a research scientist - maybe you're an undergrad doing a lab.

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If you would like to improve these wiki pages, you will just need to get an OpenWetWare account ([[OpenWetWare:How_to_join |which is easy]]).

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If you have no access to a lab, there are a number of important other things needed, labelled as such on the [https://github.com/OpenSourceMalaria/OSM_To_Do_List/issues?state=open To Do List].

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==Licence==

==Licence==

The OSM project's licence unless otherwise stated is [http://creativecommons.org/licenses/by/3.0/ CC-BY-3.0] meaning you can use whatever you want for whatever purpose, provided you cite the project.

The OSM project's licence unless otherwise stated is [http://creativecommons.org/licenses/by/3.0/ CC-BY-3.0] meaning you can use whatever you want for whatever purpose, provided you cite the project.

Current revision

Open Source Malaria (OSM) is aimed at finding new medicines for malaria using open source principles, embodied in the 6 Laws of Open Research. At the moment the majority of work involves the synthesis of analogs of compounds identified by big pharma, with the aim of improving their potency while making the molecules more "druggable", what is known as a "hit-to-lead" campaign.

For a good general overview, see the April 2014 newsletter, which can be downloaded as a PDF here. Answers to many common questions can be found in the FAQ page

This wiki describes where the project is up to, and archives some data and loose ends. For everything else about the project, see the main Project Landing Page. For a list of current to do items that can be filtered by type and series, see the To Do List.

About OSM, What's Needed and how to Contact

The background to the project may be found in the Story so Far. Publications from the project and other outputs are in the Links page, along with media about the project.

The main resources needed in the OSM project are experimental input, particularly chemical compound synthesis and help with chem/bioinformatics. Anyone can make compounds, get them tested and contribute data. You don't have to be a research scientist - maybe you're an undergrad doing a lab.

If you have no access to a lab, there are a number of important other things needed, labelled as such on the To Do List, such as things to do with writing or PR to help spread the word.

Ideally everything happens in the public domain through any of the ways shown on the Landing Page but you can in the last resort contact the consortium using opensourcemalaria@gmail.com

Help Maintain this Wiki

If you would like to improve these wiki pages, you will just need to get an OpenWetWare account (which is easy).

Licence

The OSM project's licence unless otherwise stated is CC-BY-3.0 meaning you can use whatever you want for whatever purpose, provided you cite the project.