This illustration compares the trajectories of the proposed modalities of intervention necessary to achieve the target (7) of a 7-year average postponement of the onset of age-related degeneration, depicted in terms of (A) an exponential rise in mortality rates and (B) survival. The black trajectories indicate scenarios if no interventions are applied. Nutritional and other public health interventions would need to be applied aggressively and from an early age (ideally prenatally) (yellow trajectories). Metabolic interventions applied from an early age would suffice even if they only mildly slowed the rate of accumulation of aging damage (purple). Metabolic interventions applied only from middle age would need to at least halve this rate—a daunting challenge (green). Late-onset regenerative therapies would postpone biological aging by substantially reversing the initial level of aging damage and then allowing it to continue as normal, but they would also be challenging to implement comprehensively enough (blue). A combination of more modest implementations of the late-onset metabolic and regenerative approaches seems most tractable and could lead to an equal or greater extension of healthy productive life (red).