A double mutant (A30P/A53T) of alpha-synuclein gene that has been
linked to autosomal dominant early onset Parkinson’s Disease (PD).
Alpha-Synuclein (α-Synuclein) is a 14 kD (140 amino acids) acidic
presynaptic protein. It is a major component of PD aggregates and is
implicated in the pathogenesis of PD and related neurodegenerative
disorders.