O'Donnell will play Katie O'Grady, an old school friend of main character Fran (Fran Drescher) and Judi (Tichina Arnold). She arrives to help Fran with her relationship with her difficult mother Dori (Rita Moreno).

Aykroyd will appear as a potential love interest for Fran, after her ex Peter (John Michael Higgins) sets them up.