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Natural luxury may seem like an oxymoron, but this week's Escape is ready to challenge any thoughts that once separated simple beauty from elegant comfort. Get away to the spectacular Sangre de Cristo Mountains in Santa Fe, and get ready to bask in supposed opposites at the Inn and Spa at Loretto.

Let the sun lead the way to this recently renovated hotel that mirrors the layered architecture of the Taos Pueblo, a national landmark. Once your car is shaded with included valet parking, open the door to your Traditional Room—with a complimentary upgrade to a Superior Room based on availability—for a one-night stay for two with resort fees waived ($109) and get to know the rugged desert's opulent side.

Your room glows in warm campfire hues that complement the area's appreciation for Native American folklore, but you will be far from roughing it. Wrap yourself in a patterned blanket atop your soft bed to watch a movie on your 42-inch flat screen. But be sure to take in the sights of the surrounding mountains, garden, or nearby historic district outside (Superior Rooms have private or shared balconies).

Order a happy hour drink at the Living Room Lounge, and greet fellow Escapees on a shared leather couch. Then, enjoy dinner at Luminaria—like the grilled sterling beef tenderloin—while sitting on a lantern-lit patio that's across from The Loretto Chapel.

Go for a morning swim in the heated outdoor pool, and then drink in-room tea while using the free Wi-Fi and iPod dock. After, pick up dust while exploring the nation's oldest capital city on two wheels, courtesy of Mellow Velo. Wander the Georgia O'Keeffe Museum or the Manitou Galleries before riding the tame trails outside the historic district. When your joints get sore, schedule a pampering treatment at the top-rated The Spa at Loretto, a favorite of Condé Nast Traveler.