"Any time we have a rough time with Duke, he's like, 'What do you think about just one?'" she said with a laugh. "I'm like, 'Bill, I'm Italian, I need a big family.' I mean, there's nothing more beautiful. I think [you should] have as many kids as you can handle!"

Adding, "Why not? And I think that in the future, we'll be so glad that we had as many kids as we did."

Despite his temporary hesitation about to adding to their family, the E! News host said Bill is an excellent dad to their 9-month-old son.

"I think Bill is an incredible father -- so loving," she said. "There are times where I definitely think Bill is a better parent. If I'm at work, Bill will step in and he's just a great dad. Instead of sitting the kid in front of cartoons, he takes him out and tries to engage with him and do whatever he can with him.

"He just wants to be as involved as possible with the baby," she continued. "And there are some nights I'll say, 'Let's go out to dinner with friends tonight.' And he'll go, 'No, let's stay in with the baby.' So its little things like that."

Giuliana, a breast cancer survivor who underwent a double mastectomy in 2011, also shared her reaction to the news of Angelina Jolie's mastectomy.

"It was definitely shocking. But good for her, man. She took her health into her own hands and that's what it's all about," she said. "She took her risk to get breast cancer so far down. She took it from, I think, 85 percent to less than five percent and that's why I went public. I just wanted to get out there and encourage women to take their health into their own hands because if you don't care about your health, who the hell is going to care about your health? You've got to do it."

For Giuliana, she said the most terrifying part of her cancer ordeal were the overwhelming thoughts and devastation that really hit home in the middle of the night.

"I feel so bad when I meet a woman who doesn't have a husband or a boyfriend or someone that can take care of her...I don't know how they do it," she shared. "More than anything, yes, [Bill] was at all the doctor's appointments, but where I really needed Bill was at 2 o'clock in the morning when I would wake up sweating and crying and just devastated. That's where I needed Bill to calm me down and talk me off the ledge."

The 38-year-old mom encouraged people who have friends or family members dealing with cancer to try to be there for them through the night.

"I wish there was a way I could be with these women, in the middle of the night when they wake up like that, because that's the scariest thing," she said. "That's why I always say to friends of women going through breast cancer, try to sleep over, try to be there, 'cause that's when you really need someone -- in the middle of the night when you just wake up and your just like, 'What the hell is going on?'"

"Giuliana & Bill" Season 7 premieres on July 16 at 8/7c on The Style Network.