Library: Viewing all articles on "Multiple myeloma"

Agent orange (AO) was a defoliate used extensively in the Vietnam War. It contained a possible carcinogen called TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin). AO exposure (AOe)has been linked to sarcoma, Hodgkin’s disease and non-Hodgkin’s lymphoma, with some evidence for respiratory cancers, prostate cancer (PCa) and multiple myeloma. Early detection of PCa has not been especially successful using the […]

Epigenetics is the field of study of changes which can take place in the ways that genes of cells are expressed without any actual change in DNA. These alterations can result from a variety of factors, including environmental contaminants, such as pesticides (insecticides and herbicides), heavy metals, and *endocrine disruptors. The epigenetic changes can continue […]

The proteasomes of cells regulate apoptosis (a natural form of cell death for abnormal cells.) Proteasome activity is increased in cancer cells. Proteasome inhibition arrests cell growth and induces apoptosis in abnormal cells. Proteasome inhibition is seen as a useful therapy against cancers such as multiple myeloma and non-Hodgkin’s lymphoma. Because of the toxicity of […]

This study included patients with cutaneous T-cell lymphomas (CTCL), such as mycosis fungoides, and peripheral T-cell lymphoma unspecified (PTCLU) with isolated skin involvement. Twelve patients were studied. The patients were relapsed from previous treatments or “refractory to treatment.” The diagnosis was by biopsy. In this study, the patients were treated with a medication, bortezomib, which […]

Bortezomib is a pharmaceutical proteasome inhibitor which is a strong treatment for multiple myeloma. Bortezomib induces apoptosis in leukemia cells in the laboratory. Yet, it is not effective in human studies of chronic lymphocytic leukemia (CLL). (Proteasome inhibition in the bone marrow is 1/2 that in the blood.) We eat about 23 mg. of flavonoids […]

Multiple myeloma is a disease in which malignant plasma cells fill the bone marrow. The result is severe bone disease caused by destruction of bone by osteoclast cells and reduced new bone formation by osteoblast cells. Bone loss promotes the further growth of myeloma cancer cells. The patients that first respond to current treatments may […]

Angiogenesis (the formation of new blood vessels) in the bone marrow increases with the progression of multiple myeloma (MM.) MM is a cancer of plasma cells in the bone marrow. The present study was done to evaluate the effect of resveratrol on MM angiogenesis. Angiogenesis is induced by a natural protein called vascular endothelial growth […]

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