The staff of the Institute are the authors of many other publications, and organise or help to organise exhibition projects in the Czech Republic and abroad. Many of them are active at universities as teachers or as doctoral students. The Institute is involved in various Czech and international projects, and cooperates with many research institutes and experts both in the Czech Republic and elsewhere. It is a member of the international association RIHA (Research Institutes in the History of Art).

The specialist activity of the Institute is divided into five departments

The cycle of lectures Collegium Historiae Artium, which is organised by the Institute, has become a renowned specialist platform for lectures by Czech and international scholars.

The Institute publishes Umění / Art, the only internationally respected academic art history periodical in the Czech Republic, and Studia Rudolphina (the bulletin of the Research Centre for Visual Arts and Culture in the Age of Rudolph II), and is joint publisher of the magazine Estetika. Other specialist works are prepared for publication by the Institute's publishing house Artefactum.