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NFL Opening Betting Lines: Week 15 Odds

Coming off an ugly loss and with the betting trends not on their side the San Francisco 49ers have opened as big road underdogs for Week 15 for their Sunday afternoon matchup with the division-rival Seattle Seahawks at CenturyLink Field.

The Niners fell to the Oakland Raiders in Week 14 as big favorites to sit at 7-6 SU and 5-8 ATS on the season, while the Seahawks are coming off a win over the Philadelphia Eagles that has them at 9-5 SU and 7-6 ATS. With San Francisco 1-4 SU and 0-5 ATS in its last five games against Seattle, the Seahawks opened as strong 7.5-point home favorites for Sunday afternoon.

The Eagles, meanwhile, opened as 3.5-point home favorites for their Week 15 Sunday night game against the Dallas Cowboys. Dallas lost 33-10 at home to Philadelphia as a 3-point favorite on Thanksgiving Day, and the teams enter the week as co-leaders in the NFC East at 9-4 SU.

Thursday Night Football this week has the St. Louis Rams opening as a 3-point home favorite against the Arizona Cardinals, while for Monday Night Football it's the New Orleans Saints opening as a 3-point road favorite against the Chicago Bears. The Saints and the Bears are both struggling at 5-8 SU and ATS heading into that primetime contest.

The Baltimore Ravens are the biggest favorite on the Week 15 opening lines at -12.5 at home against Jacksonville, with Kansas City at -9.5 at home against Oakland, New England at -7.5 at home against Miami, Indianapolis at -7 at home against Houston, and Detroit at -7 at home against Minnesota.

The Denver Broncos are road favorites against a division rival for Week 14, with Peyton Manning and company opening at -3.5 against the San Diego Chargers as they try to solidify their lead atop the AFC West standings. The Green Bay Packers opened at -6 on the road at Buffalo, while the Bengals vs. Browns and Steelers vs. Falcons matchups both opened as a pick'em.

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