Abstract

BACKGROUND:

With the advancement of next generation sequencing technology, researchers are now able to identify important variants and structural changes in DNA and RNA in cancer patient samples. With this information, we can now correlate specific variants and/or structural changes with actionable therapeutics known to inhibit these variants. We introduce the creation of the IMPACT Web Portal, a new online resource that connects molecular profiles of tumors to approved drugs, investigational therapeutics and pharmacogenetics associated drugs.

CONCLUSION:

IMPACT Web Portal allows for sequencing data to be linked to actionable therapeutics for translational and drug repurposing research. The IMPACT Web Portal online resource allows users to query genes and variants to approved and investigational drugs. We envision that this resource will be a valuable database for personalized medicine and drug repurposing. IMPACT Web Portal is freely available for non-commercial use at http://tanlab.ucdenver.edu/IMPACT .

IMPACT Web Portal. a Query page. User could query single gene and variant, or query a list of genes and variants in the query box. The syntax for query genes are listed next to the query box. b Results page. Query genes and variants are matched with the IMPACT database, and returned as results in three levels: Level 1: Approved drugs; Level 2: Investigational therapeutics and Level 3: Pharmacogenetics drugs. The list is sorted by hypergeometric p-value. c Drug/compound page. By clicking the drug/compound in the results page, it will link to the drug/compound page. For each drug/compound page, the top part of the page provides molecular information about the drug/compound, with external link out to PubChem. The middle part of the page provides the list of target genes and variants, and the database sources where these drug-target genes and variants were collected in the IMPACT database. The bottom part of the page provides the list of clinical trials of the drugs/compounds, with link out to ClinicalTrials.gov