The metabolic changes in the adult have at sundry times and by many careful investigators received due attention, but it is very infrequent to see them investigated in childhood, whether in health or disease; and meeting a case where this research could be carried out and where the bodily health was away from the normal, I have herein set myself the task of studying the metabolism in a child suffering not only with an aggravated form of diabetes mellitus, but where such metabolism was further modified by the fact that he was a congenital cretin.

In the light of recent assertions as to the genesis of diabetes mellitus and the interrelation of it and other dyscrasæ of similarly hitherto unknown etiology, the case assumes still further interest if we debate the question of the interrelation of the two dyscrasæ found here. How far was the improvement in the child's mental