GUTS Shiny Application

This web page allows interactive simulations of the General Unified Threshold model of Survival (GUTS)
based on the scaled internal concentration either with a constant or a time-variable exposure concentration profile.
The two reduced (RED) versions are implemented: the stochastic death version (GUTS-RED-SD) and the individual tolerance version (GUTS-RED-IT). See [
1
,
2
] for details.

All calculations can be run directly within the
R
software by using package
morse
; a tutorial is available
here
.

3. EFSA PPR Panel. 2018. Scientific Opinion on the state of the art of Toxicokinetic/Toxicodynamic (TKTD) effect models for regulatory
risk assessment of pesticides for aquatic organisms. EFSA Journal. 16: 5377. Available at
https://www.efsa.europa.eu/en/efsajournal/pub/5377