State police say the incident happened before 7 a.m. on Interstate 376, shortly after the bus left the downtown Pittsburgh terminal.

A Greyhound spokesman says the 21-year-old woman screamed to alert the driver, who pulled over and called police. The bus has resumed the trip to New York City, although the spokesman says he doesn't know if the woman remained on board.

Troopers say the man was mumbling and may have mental health issues, which will be reviewed while he's held at the Allegheny County Jail.

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