Okay, I normally just mention releases of 1980s cartoons on DVD, in keeping with the name and nature of the site and all.

But WOW!- Have you all seen all the '80s sitcoms that are being released to DVD? And I don't mean just the more mainstream hits- there's some pretty obscure stuff coming out too!
I mean- I've been pretty happy to see Full House get released in its entirety because it's one of those '80s sitcoms I grew up watching and I can happily watch over and over again.
The Cosby Show is out in its entirety on DVD- and I would definitely say the Complete Series set would be the way to go- the Season 1 DVDs have been fixed so that they are now uncut on the Complete Series release set!
And another favorite- Family Ties- is quick on its way to getting all the seasons out on DVD. Season 5 is coming March 10, 2009 by the way! (see cover art here- hey, they finally used the classic green "Family Ties" logo from the show!)
http://tvshowsondvd.com/news/Family-Ties-Season-5/11032
And Charles in Charge has gotten Seasons 1-3 out- I hope Seasons 4-5 will follow soon! I love that show!

And other series have gotten started that I still hope will be completed someday- like
Who's The Boss? (Season 1 has been out for a while now. Where's Seasons 2-8?)
Growing Pains (Got Season 1, now we need Seasons 2-7)
Perfect Strangers (It was great getting Seaons 1-2, now let's get Seasons 3-8!)
and it started in the '70s- 1978 to be exact
but I'd love to see Diff'rent Strokes get Seasons 3-8 released too!
At least another '70s favorite- Happy Days, still seems to be moving along- Season 4 just recently released- hopefully Seasons 5-11 won't be too far behind!
And I was pretty amazed when I saw Bosom Buddies get released a while back- that's now out in its entirety on DVD. (well, it might still have some music edited, etc.- but all the episodes have been released)