Target details

Target details

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Alternative Name

SOCS1

Background

SOCS1 represents a family of proteins that regulates responses to cytokines. The SOCS family comprises at least 8 members, SOCS1 to SOCS7 and CIS (cytokine inducible SH2 containing protein). Structurally, the SOCS proteins are composed of an N terminal region of variable length and amino acid composition, a central SH2 domain, and a previously unrecognized C terminal motif named the SOCS box. SOCS1 (also known as Janus kinase binding protein and STAT induced STAT inhibitor 1) was isolated independently by its ability to interact with Janus kinase 2 in a 2 hybrid screen and on the basis of antigenic similarity with the SH2 domain of STAT3. SOCS 1 inhibition of signal transduction appears to occur by binding to and inhibiting the catalytic activity of members of JAK family of cytoplasmic kinases (direct JAK2 kinase inhibition). Biochemical characterization as well as gene disruption studies indicate that SOCS1 is an important negative regulator of JAK-STAT signal pathway.Synonyms: JAB, JAK-binding protein, SOCS-1, SSI-1, SSI1, STAT-induced STAT inhibitor 1, Suppressor of cytokine signaling 1, TIP-3, TIP3, Tec-interacting protein 3