Additional files

Additional file 1:

A supplementary file containing. 1) Supplementary methods containing details of the OAI database, ethical approval
and eligibility assessment, and OAI exclusion criteria. 2) Supplementary results containing
details of the robustness of patient reported medication use and the combinations
of medications used by participants. 3) Supplementary Table S1 showing combinations
of analgesics and nutraceuticals taken by subjects at baseline. 4) Supplementary Table
S2 showing changes in nutraceutical use at 36 months relative to baseline according
to demographic and clinical variables and change in pain. 5) Supplementary Table S3
showing changes in analgesic medication use over 36 months according to demographic
and clinical variables and change in pain.