The current range of Froelichia gracilis is due in large part to its introduction via railroads during the past 100 years, and the majority of records for the species east of the Mississippi River occur on or near railroads. S. F. Blake (1956) discussed this eastern spread of the species. Froelichia gracilis is considered a minor invasive weed in the Northeast; its adaptation to open sandy or gravely soils will restrict its spread to open sites with poor soil.

In regions where their ranges overlap, Froelichia gracilis may hybridize with F. floridana. Plants with intermediate form from Texas and the Midwest have been noted. Suspected hybrids appear closest in habit to F. gracilis and will generally key to that species. Floral structure will be intermediate and variable; the branching will be typically less than in F. gracilis and present distal to the base.