This is in reference to the case report published in Ind J Dermatol Venereol Leprol, 1991; 57: 98-99. The report by Mittal et al describes a case of Sjdgren­Larsson syndrome. They state that an abnormality of lipid metabolism is suspected as a cause of the syndrome. I wish to bring it to the notice that Rizzo et al have already reported on the biochemical abnormality that is found in patients with Sjogren­Larsson syndrome.[1],[2] The cultured skin fibroblasts and leukocytes from patients with this syndrome are deficient in the enzyme fatty alcohol : nicotinamide adenine dinucleotide oxidoreductase. The deficiency of this enzyme results in elevated plasma fatty alcohols in most patients with Sjogren­Larsson syndrome. A genetic heterogenicity in the phenotype is suggested by the absence of aberrant lipid metabolism in a minority of the patients with Sjdgren­Larsson syndrome.