A new film is currently in production, and a killer is on the loose. The murders draw a reporter, ex-cop, and young woman to the set of the movie inspired by their life. They soon find out that they are dealing with a trilogy, and in a trilogy...anything can happen.

Sidney is hibernating in the woods, her whereabouts are unknown to everyone but Dewey. After a number of murders that seem to be related to the Woodsboro case take place on the set of Stab 3, Sid comes to Hollywood to be terrorized, find out more about her mother's death, and put together the final pieces of the Scream mystery.

In the final installment to this trilogy, a murdering spree begins to happen again; this time targeted toward the orginal Woodsboro survivors and those associated with the movie-inside a-movie, Stab 3. Sydney must face the demons of her past to stop the killer(s).

While "Stab 3" is in production, somebody in a ghost mask starts to murder the new cast members. This lures Sidney out from hiding deep in the woods where she lives, and she comes to Hollywood to face the killer for the final act.