Harrison and colleagues [1] compared 10-mg and 5-mg loading doses of warfarin. Subsequent doses were determined by nomograms. Most physicians would consider the loading dose to be the dose or doses given over the first few days or until an end point had been reached (for example, an international normalized ratio [INR] of 2 to 3). It would be useful to know what the nomograms were to better evaluate the effect of the “loading dose” versus subsequent doses on the data.