I have had depression for 18 years, Only once did an antidepressant work which was Dothaipin right at the start but two more times using it I got nothing, I've been put on 8 other antidepressants and i get nothing whatsoever from them not even a hint, I just wondered if there was any known reason why this might be, I do have all the classic depressive symptoms. My Doc says that there' not likea medical reason why they don't help my symptoms, am totally baffled as to why after trying so many in the different 'families' of tablets why would nothing come remotely close to lifting my mood?

It's very common for people to have very low anti-inflammatory reserves.
http://www.ncbi.nlm.nih.gov/pubmed/22264449
"Traditionally living populations in East Africa have a mean serum 25-hydroxyvitamin D concentration of 115 nmol/l." 46ng/ml

At 50ng/ml vitamin D3 is most efficient at fighting inflammation.
Get a 25(OH)D Vitamin D blood spot test by post and check your level.
Below 50ng/ml 125nmol/l means you are probably experiencing more inflammation than necessary.
Many people have levels around 10ng/ml 25nmol/l so need huge amounts of vitamin D to restore 25(OH)D to the natural level. Living naked creates 10,000~20,000iu every day in summer but effective strength vitamin D capsules are more practicable. 1000iu/daily for each 25lbs you weigh is usually sufficient but check after 3~5 months to ensure you've reached an optimum natural level at or above 50ng/ml 125nmol/l.

Magnesium also is in short supply in modern diets. We mostly consume only half of the RDA for magnesium because most modern foods spend less time in contact with soil and have less magnesium now than they would have had grown less intensively.
So a regular magnesium supplement (ideally a chelated form) but magnesium malate or citrate are fine with each meal and before bed will help Vitamin D3 better switch from it's circulating form (calcidiol) to the active hormonal from (calcitriol)

Because modern foods often include omega 6 vegetable oils (corn, soy, sunflower, rape etc) these promote inflammation. We generally need more Omega 3 (fish, fish oil, flaxseed) to counterbalance and resolve the effect of omega 6. The omega 3 DHA also doubles as a Vitamin D Receptor ligand, so it binds with the receptor and makes Vitamin D work more effectively.

Human DNA is set to produce the anti-inflammatory Vitamin D3 from dawn to dusk (given UVB exposure from sunlight). That same bright light resets our circadian rhythm so that at dusk and through till dawn our pineal gland produces MELATONIN, Melatonin is another anti-inflammatory agent that reduces chronic low-grade inflammation and oxidative stress. Getting to bed earlier, sleeping in a totally dark bedroom, using FLUX software on digital displays to enable melatonin secretion before bedtime will all help improve sleep quality and lower your inflammatory status.

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