ConclusionThe OPTIMISMM phase 3 study in early RRMM reported a significant and clinically meaningful PFS improvement in patients who were entirely LEN exposed, including 70% of patients who were refractory to LEN. Of note, the PFS and overall response rate results showed improved benefit with PVd over Vd in patients who had only 1 prior line of treatment. Follow-up for long-term survival is ongoing. The safety of POM-based treatment was manageable and consistent with its well-established profile.

2-hour infusions of MOR202 administered at up to 16 mg/kg with Dex or in combination with an IMiD/Dex in heavily pretreated pts with RRMM showed a favorable safety profile, including excellent infusion tolerability. Promising preliminary efficacy and long-lasting tumor control were observed.

ConclusionThese final results confirm the promising clinical activity and manageable safety profile of ISA in combination with Pom/dex in heavily pretreated RRMM. A Phase III confirmatory trial is ongoing with results expected later in 2018.

ConclusionMonotherapy with DARA demonstrates encouraging efficacy in previously-treated patients with AL amyloidosis with deep and rapid hematological responses. The administration of DARA in these patients is associated with a good safety profile and non-severe adverse events occurring mostly after the first infusion. The data, in particular hematological and organ responses, will be updated at the meeting. A prospective randomized international phase III study (AMY3001) in naive patients with DARA in combination with bortezomib, cyclophosphamide and dexamethasone is ongoing.

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In the largest study so far undertaken, US researchers have shown that testosterone replacement slows the recurrence of prostate cancer in low-risk patients. This may call into question the general applicability of Nobel-Prize winning hormonal prostate treatment. The work is presented at the European Association of Urology congress in Barcelona.