Abstract: :
Purpose: To study the efficacy and biotolerance of ADAL-2® bioadhesivein conjunctival sealing.Methods: A double masked randomizedstudy was done. 50 eyes (post surgery) were assigned to oneof two groups. Group I: conjunctival suture with Vicryl® 8-0,Group II: conjunctival sealing with ADAL-2® bioadhesive. Patientshad undergone either surgery for cataract, strabismus or pterygium.(35 female, 15 male. Average age 49.54 ± 28.76 years(range 28-75). Patients were assessed up to one month post-upas follows: Efficacy of closure of wound site by microscopy.Inflammatory reaction (edema, injection, secretion type, incidenceof ulcers, and conjunctival disruption Presence of residualmaterial (adhesive or suture). Patient self-assessment of comfort(graded scale).Results: Efficacy of conjunctival sealing: Theconjunctiva was closed 88% (22 cases) in the wound site, 8%(2 cases) was open, and displaced 4% (1 case), in the GroupI. 96% (24 cases) was closed in the wound site and 4% (1 case)sealed, but displaced in the Group II. Inflammatory reaction:There weren't significant differences in different periods studiedbetween both groups. (p=0,358; p=0,366; p=0,543). There werestatistical differences in the conjunctival edema (p=0,003)at 2 weeks. There was high percentage (28%, 7 cases) of ulcersand conjunctiva holes present, at the early postoperative periods(3 and 15 days) in the Group I. Presence of residual material:There weren't significant differences (p≷0,005) between bothgroups. There were statistical difference in subjective comfort(p=0,005). The patients of adhesive group referred less discomfortthan suture group.Conclusion: The efficacy of ADAL-2® adhesiveand Vicryl 8-0 suture for the conjunctiva are comparable. TheADAL-2® adhesive is well tolerated and produces less discomfortthan traditional sutures.