Ketotifen is used to minimize the frequency and severity of asthma attacks. This medication may allow for a reduction in the use of other asthma medications. Ketotifen is not effective in treating an active asthma attack (acute attack).

Ketotifen relieves and prevents eye itchiness and/or irritation associated with most seasonal allergies. It starts working within minutes after administering the drops. The drug has not been studied in children under 3. The mean elimination half life is 12 hours.

Besides its anti-histaminic activity, it is also a functional leukotriene antagonist and a phosphodiesterase inhibitor.

ParenteralModerate to severe painAdult: 60 mg as a single dose via IM injection or 30 mg as a single IV dose. Alternatively, 30 mg every 6 hours via IM or IV admin up to a max of 120 mg daily. Halve the doses in patients weighing <50 kg. Max duration: 2 days; patient should be transferred to oral therapy as soon as possible.Elderly: 30 mg as a single dose via IM injection or 15 mg as a single IV dose. Alternatively, 15 mg every 6 hours via IM or IV admin up to a max of 60 mg daily.

Renal impairment: 30 mg as a single dose via IM injection or 15 mg as a single IV dose. Alternatively, 15 mg every 6 hours via IM or IV admin up to a max of 60 mg daily. Contraindicated in moderate to severe impairment.

OphthalmicOcular itching associated with seasonal allergic conjunctivitisAdult: As trometamol: Instil 1 drop of a 0.5% solution into the affected eye(s) 4 times daily.

Renal impairment: Contraindicated in moderate to severe impairment.

OphthalmicProphylaxis and reduction of postoperative ocular inflammationAdult: As trometamol: Instil 1 drop of a 0.5% solution into the appropriate eye(s) 4 times daily starting 24 hours after surgery. Continue for 2 weeks

Renal impairment: Contraindicated in moderate to severe impairment.OphthalmicCystoid macular oedemaAdult: As trometamol: Instil 1-2 drops of a 0.5% solution into the appropriate eye(s) every 6-8 hours starting 24 hours before surgery and continue for 3-4 weeks after surgery.

Renal impairment: Contraindicated in moderate to severe impairment.

OphthalmicPain and photophobia after incisional refractive surgeryAdult: As trometamol: Instil 1 drop of a 0.5% solution 4 times daily into the operated eye for up to 3 days after surgery.Renal impairment: Contraindicated in moderate to severe impairment.

Food(before/after)

List of Contraindications

Ketotifen and Pregnancy

Ketotifen and Lactation

Ketotifen and Children

Safety and efficacy not established in children younger than 3 years of age.

Ketotifen and Geriatic

Information Not Available

Ketotifen and Other Contraindications

Hypersensitivity to aspirin or other NSAIDs, asthma. Hypovolaemia or dehydration. Do not give postoperatively to patients with high risk of haemorrhage. History of peptic ulcer or coagulation disorders. Nasal polyps, angioedema, bronchospasm. Labour. Moderate to severe renal impairment. GI bleeding, cerebrovascular bleeding. As prophylactic analgesic before surgery. Pregnancy, lactation.