First edition. Offprint. Very good condition, pages uncut. Institution stamp on title page.* Uncommon. " the idea of sex-limited genes was initially developed by Charles Darwin himself in 1871 in his book The Descent of Man and Selection in Relation to Sex.[3] He does not distinguish between sex-limited, sex-linked, and sex-influenced genes, but refers to any gene that expresses differently between sexes as sex-limited. While this concept was still in its infancy, Darwin catalyzed the further development of sex-related selection. Thomas Hunt Morgan, fully aware of this confusing terminology, published an article in The American Naturalist in 1914 titled "Sex-Linked and Sex-Limited Inheritance."[4] This article directly acknowledges that Darwin applied the term sex-limited whenever a characteristic seemed specific to one sex. Morgan proposes the definitions for sex-linked genes and sex-limited genes that we still use today (and that were defined in the introduction above). This paper helped to distinguish between these two similar concepts and clarify much confusion in the scientific community at the time. " Wikipedia Genetics. Evolution. Thomas Hunt Morgan won the Nobel Prize in Physiology or Medicine in 1933