Current Research and Scholarly Interests
I am interested in using state-of-the-art genome editing tools in primary human cells to develop novel treatment approaches for diseases with unmet needs. The Porteus lab has established efficient methods for targeted gene correction in human hematopoietic stem cells which we are using to develop treatments for patients with immunodeficiencies and hematologic diseases. In addition, I am using gene editing of immune cells to develop the next generation of CAR T cells for cancer immunotherapy.