A technique where chakra kneaded inside the body is converted into fire, and then expelled from the mouth and shaped into a massive wall of intense flames, which covers a wide range as well. This makes the technique extremely difficult to either avoid or contain, with it requiring the combined efforts of several Water Release users in order to extinguish the flames.

Trivia

In the Weekly Shōnen Jump publication of chapter 560, the first kanji in the word 'annihilation' (滅却, mekkyaku) had been replaced with the visually similar 威 (authority, majesty), which is normally pronounced as 'i' and is also found in the name of Kamui.