Hi,
This method has been implemented in our java based software HDBSTAT. It is available at
http://www.ssg.uab.edu/hdbstat/ . It is a mature, standalone desktop application for microarray data analysis that implements the mix-o-matic procedure.
If there is enough interest we will consider releasing this method as part of an R package on a 12 month timeframe.
Hope this helps.
Tapan Mehta
Statistician 1
Section on Statistical Genetics,
Univ. of Alabama at Birmingham
tapan at uab.edu
----- Original Message ----
From: Claus Mayer <claus at bioss.ac.uk>
Cc: bioconductor <bioconductor at stat.math.ethz.ch>
Sent: Thursday, April 19, 2007 11:22:20 AM
Subject: [BioC] Fitting mixture of beta-distributions
Dear all!
I assume that some of you are aware of a paper by Allison et al from
2002 where they discuss fitting a mixture of beta-distributions (one of
them being the uniform) to the distribution of p-values from a
microarray experiment.
Has this been implemented into Bioconductor somewhere or is one of you
aware of other R libraries that could help with fitting mixture of betas?
Thanks,
Claus
--
***********************************************************************************
Dr Claus-D. Mayer | http://www.bioss.ac.uk
Biomathematics & Statistics Scotland | email: claus at bioss.ac.uk
Rowett Research Institute | Telephone: +44 (0) 1224 716652
Aberdeen AB21 9SB, Scotland, UK. | Fax: +44 (0) 1224 715349
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