Introduction=Centellaasiatica (Linn.)
Urbanis widely used as Thai folk medicine for healing the
wounds, ulcer protective, anti-inflammatory and memory improvement. It was
cultivated in many area of Ubon Ratchathani province regarding the consumption
and health promotion aspects. Although it had many health benefits, but the
data about quality control and stability testing of its products was limited.
So, this work was to assess the stability and quality of capsule contained
dried powder of Centellaasiatica. Materials and
Method=Centellaasiatica sourced form Warinchamrape
district, Ubon Ratchathani province. Fresh plant was clean and dried at 50oC
for 72 hours. After grinding, the dried powder was evaluated in terms of the water
content and flow ability. The character of Centella capsule such as weight
variation and disintegration time was performed. The stability assessment of Centella
capsules at 25oC and 30oC (room temperature) and the accelerated
condition at 45oC with 75%RH for 6 months was carried out. The
content of some active compounds such as asiaticoside and madecassoside was
quantified using HPLC method. Results= The dried powder had good flow
behavior with water content of 6.03%. At 25oC and 30oC
Centella capsule showed the acceptable characters including weight variation
and disintegration time. The initial content of asiaticoside and madecassoside
were 4.47 and 2.51 mg/g of dried powder, respectively. And the content of asiaticoside
and madecassoside were slightly changed when keeping at 25-30oC for
6 month and were in the range of 90-110% of the initial content. Conclusion=Centella capsule form Ubon Ratchathani origin exhibits some
promising character and should be stored at 25–30oC for maintaining the
active compound contents. However, the microbial limit test should be future
performed for verifying the efficacy and safety of these capsules.