Results: At wk 4, fibrosis (Picrosirius Red) in the LV of UNX CD-NP compared to UNX was decreased (UNX: 4.2±0.5, UNX CDNP: 3±0.4%, p<0.05). Aldosterone was suppressed in the CD-NP UNX group compared to the UNX group (UNX: 30.4±6, UNX CD-NP:12.6±1.8 ng/dL, p<0.05). Proteinuria was reduced in the CD-NP UNX group (p<0.001). Echocardiography demonstrated EF was higher in the CD-NP UNX group (UNX:77±2.3, CD-NP UNX: 81±3 %, p<0.05); Csr-E and Csr-E/A ratio were higher in the CD-NP UNX group (p<0.05) consistent with improved diastolic function. Blood pressure, Na and water excretions were not different between groups.

Conclusions: CD-NP decreased LV fibrosis in experimental mild renal insufficiency, suppressed aldosterone, decreased proteinuria and improved overall diastolic function without changes in blood pressure. These studies suggest a potential therapeutic role for CD-NP in the prevention of the cardiac fibrosis and diastolic dysfunction associated with experimental early chronic kidney disease.