The champions have already lost three league games in the opening weeks of the season and cannot afford more failure.

United currently sit second in the Premier League table - five points behind leaders Man City - and have won their last three games in all competitions without conceding.

Former Blues coach, Jose Mourinho will be desperate to impress during his return to west London.

Chelsea boss, Antonio Conte will be under intense pressure if his team loses again after his men were soundly defeated 3-0 against AS Roma in the UEFA Champions League.

After firing blanks in Rome, it is yet to seen if Blues can get past the well knitted United defense and much the safe hands in between the goal post for the Red Devils

No goalkeeper has kept as many clean sheets in the 'big five' European leagues since the start of 2016-17 than Manchester United's David de Gea (22).

It will also be interesting to see how the Belgian connection of Eden Hazard and Romelu Lukaku will fare for their respective teams.

Lukaku has scored 15 goals in 59 Premier League games against 'big six' opposition, averaging a goal every 295 minutes. His mins per goal ratio against non 'big six' opponents is 137 (77 goals in 137 apps)

Unfortunately, the Nigeria connection to this game is missing as Victor Moses is still out injured.

There is a high likelihood that N’Golo Kante will return for the Blues in this crucial clash.