Xyzal

OVERDOSE

Overdosage has been reported with XYZAL.

Symptoms of overdose may include drowsiness in adults and
initially agitation and restlessness, followed by drowsiness in children. There
is no known specific antidote to XYZAL. Should overdose occur, symptomatic or
supportive treatment is recommended. XYZAL is not effectively removed by
dialysis, and dialysis will be ineffective unless a dialyzable agent has been
concomitantly ingested.

The acute maximal non-lethal oral dose of levocetirizine
was 240 mg/kg in mice (approximately 190 times the maximum recommended daily
oral dose in adults, approximately 230 times the maximum recommended daily oral
dose in children 6 to 11 years of age, and approximately 180 times the maximum
recommended daily oral dose in children 6 months to 5 years of age on a mg/m² basis). In rats the maximal non-lethal oral dose was 240 mg/kg
(approximately 390 times the maximum recommended daily oral dose in adults,
approximately 460 times the maximum recommended daily oral dose in children 6
to 11 years of age, and approximately 370 times the maximum recommended daily
oral dose in children 6 months to 5 years of age on a mg/m² basis).

CONTRAINDICATIONS

The use of XYZAL is contraindicated in:

Patients with known hypersensitivity

Patients with known hypersensitivity to levocetirizine or
any of the ingredients of XYZAL, or to cetirizine. Observed reactions range
from urticaria to anaphylaxis [see ADVERSE REACTIONS].