Results: The APOE ε4 groups did not differ significantly in demographic characteristics, clinical ratings or
neuropsychological test scores. 19% of the participants’ BP measurements met criteria for hypertension and
34% reported using anti-hypertensive medications. SBP was positively correlated and DBP negatively correlated
with PiB DVR bilaterally in frontal, temporal and precuneus regions (pConclusions: These findings provide additional evidence that increases in pulse pressure in mid-life may be
associated with increased risk of AD pathology. This study provides a rationale for using brain imaging to rapidly
evaluate the efficacy of anti-hypertensive medications for the pre-symptomatic treatment of AD.