SECONDARY: To compare the clinical, virologic, and immunologic responses between the two treatment groups, and to obtain pharmacokinetic data for both drugs.

At present, AZT is considered the drug of choice for initial treatment of most children with HIV infection, although disease progression or drug intolerance is associated with its long-term use. In preliminary studies in children, d4T, another HIV inhibitor, has been well tolerated, although an optimum dose has not been determined.

Further study details as provided by National Institute of Allergy and Infectious Diseases (NIAID):

Estimated Enrollment:

230

Study Completion Date:

July 1998

Detailed Description:

At present, AZT is considered the drug of choice for initial treatment of most children with HIV infection, although disease progression or drug intolerance is associated with its long-term use. In preliminary studies in children, d4T, another HIV inhibitor, has been well tolerated, although an optimum dose has not been determined.

Patients are randomized to receive either oral AZT or oral d4T. Treatment continues until the last patient enrolled has received 52 weeks of therapy, or until the study is terminated.

Eligibility

Ages Eligible for Study:

3 Months to 6 Years

Genders Eligible for Study:

Both

Accepts Healthy Volunteers:

No

Criteria

Inclusion Criteria

Concurrent Medication:

Recommended:

PCP prophylaxis.

Allowed:

Immunoglobulin.

Erythropoietin, G-CSF, and GM-CSF.

Corticosteroids.

Ethionamide or isoniazid for TB if no alternative is available.

Pyridoxine (up to 50 mg/day) as vitamin supplement.

Patients must have:

Symptomatic HIV infection.

No more than 6 weeks of prior antiretroviral or immunomodulator therapy (other than steroids and IVIG).

Consent of parent or guardian.

NOTE:

Coenrollment on another ACTG protocol not involving antiretroviral therapy is permitted.

Up to 6 weeks of prior antiretroviral therapy or specific immunomodulator therapy (other than corticosteroids and IVIG).

Exclusion Criteria

Co-existing Condition:

Patients with the following symptoms or conditions are excluded:

Current grade 3 or worse neuropathy / lower motor neuropathy.

Other grade 3 or worse clinical or laboratory toxicities.

Known intolerance to either AZT or d4T.

Concurrent Medication:

Excluded:

Chemotherapy for active malignancy.

Patients with the following prior conditions are excluded:

History of grade 3 or worse neuropathy/lower motor neuropathy.

Prior Medication:

Excluded:

More than 6 weeks of prior antiretroviral or immunomodulator therapy.

Antiretroviral or immunomodulator therapy within 7 days prior to study entry. Ongoing drug or alcohol abuse.

Contacts and Locations

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study.
To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below.
For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00000789