Description: Serotonin syndrome is a potentially fatal and largely avoidable adverse drug reaction caused by serotonergic drugs. The steady increase in use of such drugs means all doctors need to be aware of what ... More

Description: Vadas and Liss have restated their previous finding that severe anaphylaxis is associated with low activity of the enzyme that deactivates the platelet-activating factor (PAF), PAF-acetylhydrolase (PA... More

Description: In this issue, Keijzers et al. present a survey of emergency physicians from the ACEM researcher database, aiming to inform a strategic research agenda specific to multicentre clinical research. The m... More

Description: Pharmacokinetic–pharmacodynamic (PKPD) analyses are complex and time consuming and many would believe too far removed from clinical practice to be useful for patient management. However, the clinical ... More

Description: Every year, more than 1 million cases of scorpion envenomation are reported worldwide. Although the resultant mortality is lower than that from snake envenomation, there is substantial morbidity and, ... More

Description: Aims: To investigate the relationship between decontamination procedures and seizure events caused by venlafaxine overdose and to estimate the time at which 90% of patients would have had their first ... More

Description: Objective: QT prolongation is an important complication in drug overdose, particularly with some antidepressants and antipsychotics. There are problems with the accurate measurement of the QT interval... More

Description: I thank Lugassy et al for their interest in our study. However, they provide poor reasoning for citalopram overdoses requiring prolonged monitoring. Although the metabolite didesmethylcitalopram has b... More

Description: Phospholipase A₂ (PLA₂) toxins are common and abundant components of Australasian elapid venoms. These toxins are associated with a range of activities including neurotoxicity, myotoxicity and coagula... More

Description: We have some concerns about the approach to sedation of patients with aggression and violence suggested by Professor Fulde and Associate Professor Preisz. Large numbers of patients require parenteral ... More

Description: α-Neurotoxins have been isolated from hydrophid, elapid and, more recently, colubrid snake venoms. Also referred to as postsynaptic neurotoxins or ‘curare mimetic’ neurotoxins, they play an important ... More

Description: Background: Snake envenoming is a major clinical problem in Sri Lanka, with an estimated 40,000 bites annually. Antivenom is only available from India and there is a high rate of systemic hypersensiti... More

Description: Question: Which treatments are effective for treating jellyfish stings from species in North America and Hawaii? Review scope: Included studies compared interventions for pain relief, prevention of ne... More