ISCO International Unveils High Performance Duplexer / Filter

ELK GROVE VILLAGE, IL--(Marketwire - September 25, 2007) - ISCO International, Inc. (AMEX: ISO),
a leading provider of radio-frequency management and interference-control
systems for the wireless telecommunications industry, announced today the
release of a new state-of-the-art duplexer / filter solution within its RF2
family of products.

The new high performance duplexer / filter product provides unprecedented
adjacent frequency band protection and has just completed field evaluation
with a major US CDMA wireless operator. The test site location is severely
encumbered by high power Air-To-Ground (ATG) and Safety Mobile Radio (SMR)
signal energy. The ISCO solution replaced a significantly more costly and
complex competitor's solution yet provided superior overall performance.
The customer has now placed orders for more than $700,000 of the new ISCO
RF2 duplexer / filter solution for delivery during the fourth quarter 2007.

"While we are focused on the rollout of our fully digital adaptive
interference management platform during the fourth quarter, this is an
example of how we've been able to efficiently leverage our significant
technical and operational assets to quickly address a significant need of a
major customer," said John Thode, President and CEO of ISCO.

Safe Harbor Statement

Because the Company wants to provide investors with meaningful and useful
information, this news release contains, and incorporates by reference,
certain "forward-looking statements" that reflect the Company's current
expectations regarding the future results of operations, performance and
achievements of the Company. The Company has tried, wherever possible, to
identify these forward-looking statements by using words such as
"anticipates," "believes," "estimates," "looks," "expects," "plans,"
"intends" and similar expressions. These statements reflect the Company's
current beliefs and are based on information currently available to it.
Accordingly, these statements are subject to certain risks, uncertainties
and contingencies, which could cause the Company's actual results,
performance or achievements to differ materially from those expressed in,
or implied by, such statements. These factors include, among others, the
following: market acceptance of the Company's technology; the spending
patterns of wireless network operators in connection with the build out of
2.5G and 3G wireless systems; the Company's ability to obtain financing in
the future if necessary; the Company's history of net losses and the lack
of assurance that the Company's earnings will be sufficient to cover fixed
charges in the future; uncertainty about the Company's ability to compete
effectively against better capitalized competitors and to withstand
downturns in its business or the economy generally; continued downward
pressure on the prices charged for the Company's products due to the
competition of rival manufacturers of front-end systems for the wireless
telecommunications market; the timing and receipt of customer orders; the
Company's ability to attract and retain key personnel; the Company's
ability to protect its intellectual property; the risks of foreign
operations and the risks of legal proceedings. A more complete description
of these risks, uncertainties and assumptions is included in the Company's
filings with the Securities and Exchange Commission, including those
described under the heading "Risk Factors" in the Company's Annual Report
on Form 10-K filed by the Company with the Securities and Exchange
Commission. You should not place undue reliance on any forward-looking
statements. The Company undertakes no obligation to release publicly the
results of any revisions to any such forward-looking statements that may be
made to reflect events or circumstances after the date of this Report or to
reflect the occurrence of unanticipated events.