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A rapid and label-free SERS detection method for biomarkers in clinical biofluids

Author

Kong, Kien Voon

Leong, Weng Kee

Lam, Zhiyong

Gong, Tianxun

Goh, Douglas

Lau, Weber Kam On

Olivo, Malini

Date of Issue

2014

School

School of Physical and Mathematical Sciences

Abstract

A metal carbonyl-functionalized nanostructured substrate can be used in a rapid and simple assay for the detection of A1AT, a potential biomarker for bladder cancer, in clinical urine samples. The assay involves monitoring changes in the carbonyl stretching vibrations of the metal carbonyl via surface-enhanced Raman spectroscopy (SERS). These vibrations lie in the absorption spectral window of 1800–2200 cm−1, which is free of any spectral interference from biomolecules.