Tottenham Hotspur can prevent Chelsea from becoming the first Premier League club to win 14 successive Premier League games in a single season.

Spurs will be hellbent on gaining their revenge on the Blues, who not only beat them 2-1 in the reverse fixture at Stamford Bridge but also halted their title challenge in a heated 2-2 draw last season.

Mauricio Pochettino is able to welcome back Jan Vertonghen and Kyle Walker from suspension tonight and is likely to welcome both back into the first-team fold, but has some selection decisions to make.

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Alasdair Gold - football.london Spurs correspondent

Probably the most unfortunate Tottenham Hotspur player tonight will be Kieran Trippier after his star performance against Watford.

The 26-year-old right-back weighed in with two assists on his first Premier League start of the season but is odds-on to be returning to his customary place on the Spurs bench.

That’s because England defender Walker is back and Pochettino will not stray from his first choice full-backs of Walker and Danny Rose to handle the attacking threat of Chelsea and provide the width for his own team at White Hart Lane.

Vertonghen will also return from a ban, while Mousa Dembele will be back in the starting line-up after being rested.

Moussa Sissoko was also on the bench against Watford after a string of impressive performances for Spurs and Heung-Min Son did not manage to do anything worthy at Vicarage Road of keeping his place.

Spurs fans would not have believed it in the early months after his transfer, but Sissoko’s pace, power and direct play could now end up being a key component of their team against Chelsea.

Much will depend on whether Pochettino sticks with three at the back, as he utilised against Watford, in order to match Chelsea’s formation or whether he reverts to a flat back four. If it’s the latter then Eric Dier is likely to drop to the bench which will be a big indicator as to Victor Wanyama’s place in Pochettino’s current thinking.

Sissoko should start in a 4-2-3-1 setup

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Tom Marshall-Bailey - football.london editor

Walker's presence in the starting XI will be a welcome relief to Pochettino this evening, despite Trippier's outstanding display at Watford.

The return of Spurs' first-choice on the right of defence is expected to be one of a few changes for Spurs tonight - my XI would feature just the three alterations to Sunday's team at Vicarage Road.

Walker would be joined by the returning Vertonghen and Dembele, with Wimmer and Dier the men to make way.

I think by deploying a midfield trio of Wanyama, Dembele and Dele Alli, Spurs have the physicality, athleticism and game-changing ability to win the midfield battle.