Articles

Single-use technologies in downstream process intensification

GE Healthcare Life Sciences

In bioprocessing, thorough cleaning is critical in order to take full benefit of the resin by removing impurities. When using conventional chromatography solutions, cleaning and cleaning validation consumes a considerable amount of time and facility resources. Cleaning-in-place protocols are performed before, during, and after a campaign.
A major bottleneck is the time it takes to get the results from the cleaning verification process. This problem can be addressed by using single-use technologies, which eliminate the need for cleaning and cleaning validation.