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Conclusion Synovial sarcoma expressed the genes related to chondrocyte, osteocyte, neuron, glia, and melanocyte which are known to originate from neural crest stem cells. Synovial sarcoma cells had potential to differentiate into chondrocyte, osteocyte, and neuron to various extent, but not into adipocyte. This spectrum of differentiation is similar to that of neural crest stem cells, supporting our hypothesis that “the cell-of-origin of synovial sarcoma is neural crest-derived cells”.