PSB platforms

Deuteration and isotope labelingA joint EMBL/ILL/IBS Deuteration and Isotope laboratory has been established as part of the Partnership for Partnership for Structural Biology (PSB). Its purpose is to develop tools and expertise needed to produce deuterated materials for neutron scattering experiments and NMR as well as improved systems and technologies for the production and analysis of deuterium-labelled biological macromolecules.(Further information: EMBL-ILL Deuteration Laboratory)

High-throughput crystallisationOur high-throughput crystallisation platform, based on a Cartesin nanodrop dispensing robot and Rigaku storage and visualization system, is one of the core technical platforms of the Partnership for Structural Biology (PSB). We also try to bridge the gap between high-throughput crystallisation and automated synchrotron data collection systems.

High-throughput screening for soluble protein expressionIn the context of the Partnership for Structural Biology (PSB), combinatorial approaches, screening and robotics are applied to develop novel methods to solve challenging problems of protein expression for structural biology.

Multiprotein complex expression with baculovirus/insect cell systemWithin the Partnership for Structural Biology (PSB), an active development and service programme centered around our MultiBac-EMBL technology is implemented for providing novel gene recombineering methods and engineered baculoviruses to produce challenging protein complexes with may subunits in quqlity and quantity suitable for structural biology.