Had ≥1 episode of overt HE associated with liver disease within the last 6 months

MELD score of ≥ 19

Has a close family member or other personal contact who is familiar with the subject's HE, can provide continuing oversight to the subject and is willing to be available to the subject during the conduct of the trial

Exclusion Criteria:

HIV

History of tuberculosis infection

Chronic respiratory insufficiency

Current infection and receiving antibiotics

Renal insufficiency requiring dialysis

Active spontaneous bacterial peritonitis infection

Intestinal obstruction or has inflammatory bowel disease

Active malignancy within the last 5 years

Current GI bleeding or has had a GI hemorrhage within past 3 months

Anemia

Contacts and Locations

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study.
To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below.
For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01846663