Unprecedented control of genome editing in flies promises insight into human development, disease

e may also pay off in the clinic. It can be very difficult and time-c...The work led by genetics graduate student Scott Gratz was the joint ...They have already seen tremendous interest in the work: the study whi......

e may also pay off in the clinic. "It can be very difficult and time-consuming to generate models to study all the gene variants associated with human diseases," says Wildonger. "With this genome editing approach, if we work in collaboration with a clinician to find [clinically relevant] mutations, we can rapidly translate these into a fruit fly model to see what's happening at the cellular and molecular level."

The work, led by genetics graduate student Scott Gratz, was the joint effort of three UWMadison labs particularly notable, Harrison says, that each is in a different department and headed by a female assistant professor. "This has been an amazing collaboration," she says. "It wouldn't have worked if any one of us had tried it on our own."

They have already seen tremendous interest in the work: the study, which was posted online in May, quickly became one of the most-viewed papers of the month and the researchers have fielded requests for materials and information from dozens of countries around the world.

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