A Long-Enduring, Stable Primary Hepatocyte Co-culture Model

Intrinsic Clearance and Metabolite Generation

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Presented at the 2016 Delaware Valley Drug Metabolism Discussion Group meeting in collaboration with Hμrel® corporation, this presentation describes efforts to compare suspension, plated monoculture and Hμrel® co-culture hepatocyte models for estimated clearance of low-turnover drugs, metabolite generation comparisons, as well as work that was done with Optivia Corporation to develop an integrated approach to more accurately assess cholestatic liability of drugs.