Regular:

Summary form only given, as follows. The main thrust of our research program is the development of novel concepts for advanced x-ray sources with applications in the field of protein... View More

Summary form only given, as follows. The main thrust of our research program is the development of novel concepts for advanced x-ray sources with applications in the field of protein crystallography and structural genomics, or proteomics. This rapidly growing field is expected to dominate molecular biology in the first half of the 21/sup st/ Century, as it offers a new paradigm for rational drug design, which is revolutionizing modem medicine. Such new sources must be compact, tunable, relatively inexpensive, and capable of delivering the average X-ray brightness required for these applications. Within this broad context, two specific devices will be discussed: first, a Compton scattering X-ray source based on the interaction of a terawatt-class laser pulse and a high-brightness, relativistic electron beam; second, a new radiation source concept using a low energy electron beam scattering photons off the periodic potential in a crystal lattice, at the Bragg resonance angle. In the case of Compton scattering, particular attention will be paid to a novel interaction geometry, which greatly alleviates timing jitter and synchronization issues.

View Less

Related Documents

Gene expression is a critical process in biological system that is influenced and modulated by many factors including genetic variation. Expression Quantitative Trait Loci (eQTL) analysis provides a powerful way to understand how genetic variants affect gene expression. For genome wide eQTL analysis...

RNA secondary structure has become the most exploitable feature for ab initio detection of non-coding RNA (ncRNA) genes from genome sequences. Previous work has used Minimum Free Energy (MFE) based methods developed to identify ncRNAs by measuring sequence fold stability and certainty. However, thes...

With the continuing development and improvement of genome-wide techniques, a great number of candidate genes are discovered. How to identify the most likely disease genes among a large number of candidates becomes a fundamental challenge in human health. A common view is that genes related to a spec...

Allele specific expression is essential for cellular programming and development and the diversity of cellular phenotypes. Traditional analysis methods utilize RNA and depend on single nucleotide polymorphisms, thus to suffer from limited amount of materials for analysis. The rapid development of ne...

The identification of communities is imperative in the understanding of network structures and functions. Using community detection algorithms in biological networks, the community structure of biological networks can be determined, which is helpful in analyzing the topological structures and predic...