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Problem with Zimbra MTA after upgrade to 8.0.3

Hu guys,

I'd really appreciate some experts' advice on our problem.
We have a Zimbra server that was running 7_0_1 Open Source. It was running for over an year without such a problem.
Last Friday we've updated to 8_0_3.
Since today everything was working fine. Now we cannot send emails. In the mailq we see the following entries: