Effect of zinc supplementation on growth and body composition in children with sickle cell disease

Babette S ZemelDivision of Gastroenterology and Nutrition, The Children s Hospital of Philadelphia, The University of Pennsylvania School of Medicine, Philadelphia, 19104 4399, USAAm J Clin Nutr 75:300-7. 2002

The recognition and treatment of growth disorders - a 50-year retrospective

Babette ZemelDivision of Gastroenterology, Hepatology and Nutrition, The Children s Hospital of Philadelphia, Department of Pediatrics, The University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USAAnn Hum Biol 36:496-510. 2009

Effects of delayed pubertal development, nutritional status, and disease severity on longitudinal patterns of growth failure in children with sickle cell disease

Babette S ZemelDivision of Gastroenterology, Hepatology, and Nutrition, The Children s Hospital of Philadelphia, Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USAPediatr Res 61:607-13. 2007

..Obesity associated with joint pain of the lower extremities is likely due to excessive mechanical load on weight bearing joints. Additional mechanical factors may explain the association between obesity and joint pain...

Human biology at the interface of paediatrics: measuring bone mineral accretion during childhood

..The relatively new field of paediatric bone health assessment fits this paradigm and reflects the collaboration of human biologists and paediatricians in understanding the growth of the human skeleton...

Bone mineral accretion and its relationship to growth, sexual maturation and body composition during childhood and adolescence

..Understanding these complex relationships is essential to understanding bone metabolism during this part of the life cycle and the challenges of assessing bone health in children with medical conditions that threaten bone health...

Effect of zinc supplementation on growth and body composition in children with sickle cell disease

Babette S ZemelDivision of Gastroenterology and Nutrition, The Children s Hospital of Philadelphia, The University of Pennsylvania School of Medicine, Philadelphia, 19104 4399, USAAm J Clin Nutr 75:300-7. 2002

..Poor growth and delayed maturation in children with sickle cell disease (SCD) may be due, in part, to mild zinc deficiency...

The recognition and treatment of growth disorders - a 50-year retrospective

Babette ZemelDivision of Gastroenterology, Hepatology and Nutrition, The Children s Hospital of Philadelphia, Department of Pediatrics, The University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USAAnn Hum Biol 36:496-510. 2009

..These examples accentuate the need for continued participation of human biologists in the study of growth and development and the care of children...

Effects of delayed pubertal development, nutritional status, and disease severity on longitudinal patterns of growth failure in children with sickle cell disease

Babette S ZemelDivision of Gastroenterology, Hepatology, and Nutrition, The Children s Hospital of Philadelphia, Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USAPediatr Res 61:607-13. 2007

..Growth failure and maturational delay remain significant chronic problems in children with SCD-SS and are related to potentially modifiable factors such as nutritional status...

..To characterize the energy and nutrient intake, and the degree of fat malabsorption in children with Alagille syndrome (AGS) and to examine their cross-sectional associations with growth and nutritional status...

Evaluation of formulas for calculating total energy requirements of preadolescent children with cystic fibrosis

..To evaluate fecal elastase 1 (FE) levels in young children with cystic fibrosis and pancreatic insufficiency and to explore the relationship between FE and growth, nutrition, pulmonary status and fat absorption over a 24-month period...

..Lower bone biomarkers were associated with greater cortical vBMD. Studies are needed to determine the fracture implications of these varied effects...

Interactions between growth and body composition in children treated with high-dose chronic glucocorticoids

Bethany J FosterDepartment of Pediatrics, Division of Nephrology, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, USAAm J Clin Nutr 80:1334-41. 2004

..The purpose of this study was to assess vitamin B(6) status of children with SCD-SS ages 3 to 20 years and determine its relationship to growth, dietary intake, and disease severity...

Self-assessment of sexual maturity status in children with Crohn's disease

Joan I SchallDivision of Gastroenterology and Nutrition, Department of Pediatrics, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USAJ Pediatr 141:223-9. 2002

..To evaluate the validity of self-assessment of sexual maturity status (SMS) in children with Crohn's disease (CD), a pediatric chronic disease that often affects growth and development...

Low vitamin D status in children with sickle cell disease

Anne M BuisonDivision of Gastroenterology and Nutrition, The Children s Hospital of Philadelphia, University of Pennsylvania, 19104, USAJ Pediatr 145:622-7. 2004

..To examine vitamin D status in children with sickle cell disease (SCD)-SS and its relation to season and dietary intake...

..Serum 25-hydroxyvitamin D [25(OH)D] concentrations serve as a biomarker for vitamin D stores. Prior studies have not examined the risk factors for low vitamin D concentrations in a multiethnic sample of US youth across a broad age range...

Bone mineral content deficits of the spine and whole body in children at time of diagnosis with celiac disease

Muralidhar JatlaDepartment of Pediatrics, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, USAJ Pediatr Gastroenterol Nutr 48:175-80. 2009

..The secondary aim was to examine the effect of histological grade on BMC...

..In conclusion, WA-BMD may be more sensitive to disease effects in children because it selectively measures the trabecular-rich vertebral body and is independent of growth-related changes in BMC of the dense spinous processes...

Vitamin A intake and elevated serum retinol levels in children and young adults with cystic fibrosis

Asim MaqboolDivision of Gastroenterology, Hepatology, and Nutrition, The Children s Hospital of Philadelphia, Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USAJ Cyst Fibros 7:137-41. 2008

..Individuals with cystic fibrosis (CF) and pancreatic insufficiency (PI) are at risk for fat-soluble vitamin deficiency, including vitamin A. Recent evidence suggests current practices of vitamin A intake results in elevated serum retinol...

Progressive bone mineral content loss in children with intractable epilepsy treated with the ketogenic diet

..Dietary intake was particularly poor in adolescents. Efforts are needed to ensure dietary adequacy in children with sickle cell disease, type SS and to understand the etiology of poor dietary intake...

Gender differences in body composition deficits at diagnosis in children and adolescents with Crohn's disease

Serum linoleic acid status as a clinical indicator of essential fatty acid status in children with cystic fibrosis

Asim MaqboolDivision of Gastroenterology, Hepatology, and Nutrition, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USAJ Pediatr Gastroenterol Nutr 47:635-44. 2008

Meena ThayuDepartment of Pediatrics, The Children s Hospital of Philadelphia, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USAGastroenterology 139:430-8. 2010

..Pediatric Crohn's disease (CD) is associated with growth, lean mass (LM), and fat mass (FM) deficits. This study assessed and identified determinants of changes in height and body composition in children with CD following...

Deficits in bone mineral content in children and adolescents with cystic fibrosis are related to height deficits

Andrea KellyDivision of Endocrinology Diabetes, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USAJ Clin Densitom 11:581-9. 2008

..Obesity is a common yet incompletely understood complication of childhood craniopharyngioma. We hypothesized that craniopharyngioma is associated with specific defects in energy balance compared to obese control children...

Mary B LeonardDepartment of Pediatrics, Departments of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USAPediatr Clin North Am 49:143-73. 2002

..Further research is needed to characterize these changes and their use in the assessment of bone health and fracture risk in children. Only then can the impact of treatment strategies be appreciated fully...

Plasma zinc and growth status in preadolescent children with cystic fibrosis

Asim MaqboolDivisions of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA, USAJ Pediatr Gastroenterol Nutr 43:95-101. 2006

Mild to moderate cystic fibrosis is not associated with increased fracture risk in children and adolescents

Alisha J RovnerDivision of Gastroenterology, The Children s Hospital of Philadelphia, Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USAJ Pediatr 147:327-31. 2005

..To determine whether children and adolescents with cystic fibrosis (CF), pancreatic insufficiency (PI), and mild-to-moderate lung disease have an increased risk of fracture compared with concurrent healthy control subjects...

Adolescent development and energy expenditure in females with cystic fibrosis

Virginia A StallingsDepartment of Pediatrics, Division of Gastroenterology and Nutrition, The Children s Hospital of Philadelphia, The University of Pennsylvania School of Medicine, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USAClin Nutr 24:737-45. 2005

..We determined the effects of long-term treatment with glucocorticoids on bone mineral content in children with glucocorticoid-sensitive nephrotic syndrome, a disorder with minimal known independent effects on bone...

..Studies of the effect of childhood obesity on bone accrual during growth have yielded conflicting results, largely related to the failure to adequately characterize the confounding effects of growth, maturation, and body composition...

Vitamin A status, hospitalizations, and other outcomes in young children with sickle cell disease

Joan I SchallDivision of Gastroenterology and Nutrition, Department of Pediatrics, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, 19104, USAJ Pediatr 145:99-106. 2004

..To determine the relation of serum vitamin A status to growth, nutritional and hematologic status, and to the number of hospitalizations in children with sickle cell disease-SS (homozygous for the S allele, SCD-SS)...

Elevated vitamin A intake and serum retinol in preadolescent children with cystic fibrosis

..In conclusion, paired Hologic PA lateral scans may increase sensitivity to growth-related increases in trabecular BMC and density in the spine, with less bias due to magnification error...

Energy balance and the accuracy of reported energy intake in preadolescent children with cystic fibrosis

Jillian TrabulsiDivision of Gastroenterology, The Children s Hospital of Philadelphia, Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USAAm J Clin Nutr 84:523-30. 2006

..Suboptimal growth and nutritional status are common among children with cystic fibrosis (CF) and pancreatic insufficiency (PI). A better understanding of energy balance is required to improve prevention and treatment of malnutrition...

Statistical validation of air-displacement plethysmography for body composition assessment in children

..Subperiosteal width and section modulus were significantly lower in CD and greater in SSNS compared with controls, highlighting the importance of the underlying disease, persistent inflammation, and alterations in lean mass...

Rapid weight gain during infancy and obesity in young adulthood in a cohort of African Americans

Nicolas StettlerDivision of Gastroenterology and Nutrition, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, 19104, USAAm J Clin Nutr 77:1374-8. 2003

..Obesity is increasing in the United States. Evidence-based prevention is a public health priority and should target well-defined risk factors and critical periods...

Vitamin E status in children with cystic fibrosis and pancreatic insufficiency

Shirley H HuangDivision of Gastroenterology and Nutrition, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 4399, USAJ Pediatr 148:556-559. 2006

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Vitamin D status in children, adolescents, and young adults with Crohn disease

..Therefore, normalizing whole body DXA bone area for height and BMC for height provided the best measures of bone dimensions and strength. DXA BMC normalized for bone area and lean mass were poor indicators of bone strength...

Quantifying calcium intake in school age children: development and validation of the Calcium Counts! food frequency questionnaire

..Impaired growth, poor nutritional status, and delayed skeletal and sexual maturation are common in children with sickle cell disease (SCD), yet the nature of associated body-composition deficits has not been fully described...

Risk factors for glucocorticoid-induced obesity in children with steroid-sensitive nephrotic syndrome

..003] in all subjects with remote glucocorticoid exposure (black and non-black). These results indicate that non-black race and increased maternal BMI are risk factors for glucocorticoid-induced obesity in subjects with recent exposure...

High risk of vitamin D deficiency in children with sickle cell disease

..However, children with SCD-SS were at greater risk for vitamin D deficiency than healthy African-American children...

Deficits in size-adjusted bone mass in children with Alagille syndrome

Irene E OlsenCenter for Epidemiology and Biostatistics and Division of Neonatology, Cincinnati Children s Hospital Medical Cente, The University of Cincinnati College of Medicine, Cincinnati, OH, USAJ Pediatr Gastroenterol Nutr 40:76-82. 2005

..To describe bone status in children with Alagille syndrome (AGS) and healthy control children adjusted for age, gender and height (HT), and to identify dietary intake and AGS-related factors associated with bone status...

Sensitivity of dual x-ray absorptiometry to stature and reference data source in pediatric patients: comment on the article by Stewart et al

Jon M BurnhamArthritis Rheum 50:2378-9; author reply 2379-80. 2004

Markers of bone turnover are associated with growth and development in young subjects with sickle cell anemia