At the first ESPY Awards, Jim Valvano gave one of the most memorable and inspirational speeches in sports history. He was diagnosed with terminal cancer a year earlier and passed away a month after the show. Since then, the Perseverance Award has been named in his honor.

Pat Summitt's Speech (2012)

In August 2011, Summitt, one of the greatest college basketball coaches in history was diagnosed with Early-onset Alzheimer's Disease. After finishing the 2011-2012 season with another SEC championship, Summit retired. At the 2012 ESPYs Summit received The Arthur Ashe Courage Award.

Stuart Scott's Speech (2014)

Receiving the Jimmy V Perseverance Award, Scott said, "When you die, it does not mean that you lose to cancer. You beat cancer by how you live, why you live, and in the manner in which you live." His powerful acceptance speech taught us many things, most importantly, never give up and never stop fighting.

In June 2014, 5-year-old Leah Still, daughter of NFL defensive lineman Devon Still, was diagnosed with Neuroblastoma stage 4 cancer, giving her a 50 percent chance of survival. At the 2015 ESPYs, Devon accepted The Jimmy V Perseverance Award on her behalf. In January 2016, Leah became cancer free.

Caitlyn Jenner's Speech (2015)

Jenner won the 2015 Arthur Ashe Courage Award and two months after coming out as a transgender woman, gave one of the most powerful speeches in the history of the ESPYs. Jenner continues to inspire millions across the world to not be afraid of who they are.

Justin Timberlake's "I Love Sports" (2008)

In 2008, host Justin Timberlake sang to his audience about why he loves sports.

Justin Timberlake's Skit (2008)

Timberlake also used his Saturday Night Live skills to give us one of the best skits in ESPYs history.

Drake's Honorable Mentions

Drake took a page out of Justin Timberlake’s playbook, singing a song about the sports world's No. 2s. He then followed that up with a song about athlete's sidepieces and sung Frozen's "Let It Go" with Manny Pacquiao.

Will Ferrell As Tiger Woods (2008)

When Woods was unable to accept his award for Best Male Athlete due to injury, Ferrell took to the stage to accept it for him, as Tiger Woods, of course

Jamie Foxx Calls Out LeBron James (2003)

Jamie Foxx took to the coaching board to take shots at any athlete he could think of. Coach Do Dirty called out those from 18-year-old LeBron James to Charles Barkley to Pete Rose.

Jamie Foxx (2004)

Foxx returned the next year to disrupt Gary Payton and Terrell Owens' speeches. He was NOT happy to miss out on Coach of the Year.