The authors present evidence that the herpes simplex virus 1 (HSV1)-encoded miR H8 directly targets PIGT, a member of the protein complex that covalently attaches proteins to glycosylphosphatidylinositol (GPI) in the final step of GPI anchoring. [Cell Rep]
Full Article | Graphical Abstract

Investigators provide a detailed analysis of HLA-DR+CD38+ and HLA-DR–CD38+ effector CD8 T- cell subsets in dengue-patients from India and Thailand. Both CD8 T cell subsets expanded and expressed markers indicative of antigen-driven proliferation; tissue-homing and cytotoxic effector functions with the HLA-DR+CD38+ subset being the most striking in these effector qualities. [J Virol]
Abstract | Full Article

The authors focus on the different microenvironmental niches that characterize classical Hodgkin lymphoma of the general population as well as cases of HIV-infected patients. A more comprehensive understanding of the complex interplay existing between Hodgkin and Reed-Stenberg and tumor microenvironment is pivotal for the development of more effective treatments, particularly for relapsed or refractory diseases. [Int J Cancer]
Abstract

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Pfizer Inc. announced an award of a grant from the Bill & Melinda Gates Foundation to conduct a Phase I/II clinical trial of Pfizer’s vaccine candidate against group B Streptococcus infection, a leading cause of neonatal sepsis. [Pfizer Inc.]
Press Release

Transgene announced that the first patient has been included in the multiple dose cohort of the Phase I/Ib trial with TG1050, Transgene’s immunotherapy product candidate for the treatment of chronic hepatitis B virus infection. [Transgene SA]
Press Release

Lamar Smith has made his mark on science. As chairman of the US House Committee on Science, Space, and Technology, the Texas Republican has launched dozens of investigations into alleged wrongdoing by scientists, environmental groups and government officials. And he shows no signs of slowing down. [Nature News]
Editorial