Karve married Dinkar Dhondo Karve, who taught chemistry in a school, while studying with Ghurye. Although her husband was from a socially distinguished Brahmin family, the match did not meet with approval from her father, who had hoped that she would marry into the ruling family of a princely state. Dinkar was a son of Dhondo Keshav Karve, a campaigner for women's rights who, somewhat contradictorily, opposed Dinkar's decision to send her to Germany for further studies.[2][a]

Karve worked as an administrator at SNDT Women's University in Bombay from 1931 to 1936 and did some postgraduate teaching in the city. She moved to Pune's Deccan College as a Reader in sociology in 1939 and remained there for the rest of her career.[7]

According to Nandini Sundar, Karve was the first Indian female anthropologist, a discipline that in India during her lifetime was generally synonymous with sociology. She had wide-ranging academic interests, including anthropology, anthropometry, serology, Indology and palaeontology as well as collecting folk songs and translating feminist poetry.[8] She was essentially a diffusionist, inspired by several intellectual schools of thought and in some respects emulating the techniques used by W. H. R. Rivers. These influences included classical Indology, ethnology as practised by bureaucrats of the British Raj and also German eugenics-based physical anthropology. In addition, she had an innate interest in fieldwork.[9] Sundar notes that "as late as 1968 she retained a belief in the importance of mapping social groups like subcastes on the basis of anthropometric and what was then called 'genetic' data (blood group, colour vision, hand-clasping, and hypertrichosis)".[4]

She founded the department of anthropology at what was then Poona University (now the University of Pune).[8]

Karve served for many years as the head of the Department of Sociology and Anthropology at Deccan College, Pune (University of Pune).[citation needed] She presided over the Anthropology Division of the National Science Congress held in New Delhi in 1947.[8] She wrote in both Marathi and English.

although Karve was very well known in her time, especially in her native Maharashtra, and gets an honourable mention in standard histories of sociology/anthropology, she does not seem to have had a lasting effect on the disciplines in the way of some of her contemporaries.

She provides various possible reasons why Karve's effect has been less than that of people such as Ghurye and Louis Dumont. These include her location at an academic centre that carried less prestige than, say, those in Delhi and Bombay and because she concentrated on the classical anthropological concern relating to origins at a time when her fellow academics were moving from that to more specialised matters underpinned by functionalism. In addition, her lasting impact may have been affected due to none of her PhD students being able to carry her work forward: unlike, say, Ghurye's students, they failed to establish themselves in academia. There was also the issue of her use of a niche publisher — her employers, Deccan College — for her early works rather than a mainstream academic house such as Oxford University Press, although this may have been imposed upon her.[8]

After Karve's death, Durga Bhagwat, a contemporary Marathi intellectual who had also studied under Ghurye but left the course, wrote a scathing critique of Karve. Sundar summarises this as containing "charges of plagiarism, careerism, manipulation of persons, suppressing the work of others, etc. Whatever the truth of these charges, the essay does Bhagwat little credit."[10]

Although Karve's work on kinship was based on anthropometric and linguistic surveys that are now considered unacceptable, there has been a revival of academic interest in that and some other aspects of her work, such as ecology and Maharashtrian culture.[8]

Kinship Organization in India (Deccan College, 1953), a study of various social institutions in India.

Hindu Society — an interpretation (Deccan College, 1961), a study of Hindu society based on data which Karve had collected in her field trips, and her study of pertinent texts in Hindi, Marathi, Sanskrit, Pali and Prakrit. In the book, she discussed the pre-Aryan existence of the caste system in Hinduism, and traced its development to its present form.

Maharashtra — Land and People (1968) - describes various social institutions and rituals in Maharashtra.

Yuganta: The End of an Epoch, a study of the main characters of the Mahabharata treats them as historical figures and uses their attitudes and behavior to gain an understanding of the times in which they lived. Karve wrote the book first in Marathi, and later translated it into English. The book won the 1967 Sahitya Academy Award for best book in Marathi.[11]

^Karve studied philosophy, Sanskrit and zoology as well as eugenics for her PhD, which was titled The normal asymmetry of the human skull.[4]

^Examples of the Karve family's unconventionality include Irawati's decision not to wear any of the traditional symbols associated with married Hindu women, an unusual degree of familiarity in address between her, her husband and their children, and her being the first woman in Pune to ride a scooter.[6]

Sundar, Nandini (2007), "In the cause of anthropology: the life and work of Irawati Karve", in Uberoi, Patricia; Sundar, Nandini; Deshpande, Satish, Anthropology in the East: The founders of Indian Sociology and Anthropology, New Delhi: Permanent Black, ISBN978-1-90542-277-7