Define Skeletal-related events

How often do you need to give bisphophonates in breast CA + bone mets?

Once every 3-5 week schedule in conjunction with anti-neoplastic therapy

Recent data from a phase III study showed zoledronic acid administered once every 12 weeks vs the current standard of once every 4 weeks does not compromise efficacy - SRE rate was 22% when administered once every 4 weeks, vs 23% when administered once every 12 weeks.

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What is the expected timeframe that disease flare can be expected in bony mets?

2 months to 12 months after initiating therapy

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Any evidence for endocrine therapy post-resection of loco-recurrence in breast cancer?