Headaches - cluster

Highlights

What Are Cluster Headaches?

Cluster headaches are among the most painful types of headaches. They are marked by excruciating stabbing and penetrating pain, which is usually centered around the eye. Cluster headache attacks occur very suddenly and without warning, with the pain peaking within 15 minutes. During an attack, the patient is very restless and agitated while trying to cope with the severe pain.

Symptoms of Cluster Headache Attacks

In addition to pain, symptoms of cluster headaches may include:

Swollen or droopy eyelid

Watery, tearing eye

Stuffy or runny nose

Contracted eye pupil

Forehead and facial sweating

Intolerance to light and sound

Who Gets Cluster Headaches?

Cluster headaches are rare, affecting less than 1% of the population.

Men, usually in their 40s, are much more likely to suffer from cluster headaches than women.

Many people who have cluster headaches have a personal or family history of migraine headaches.

Treatment

Treatment of cluster headaches focuses on relieving pain when attacks occur, and on preventive strategies to reduce attack duration and frequency. Oxygen therapy and sumatriptan (Imitrex, generic) injection are the most effective treatments for acute attacks. Verapamil (Calan, generic), a high blood pressure drug, is typically the first choice of medication used for long-term prevention.

Behavioral treatments can be a helpful supplement to drug therapy. These treatments include relaxation therapy, biofeedback, cognitive-behavioral therapy, and stress management. Patients should also identify and avoid any triggers, such as alcohol use and cigarette smoking, which may provoke cluster headache attacks.

Introduction

Most people have had headaches. There are many different kinds of headaches, and they range from being an infrequent annoyance to a persistent, severe, and disabling medical condition.

The brain is insensitive to pain, so that is not what hurts when you have a headache. Rather, the pain occurs in the following locations:

The tissues covering the brain

The attaching structures at the base of the brain

Muscles and blood vessels around the scalp, face, and neck

Doctors categorize headaches as either primary or secondary. The category helps to distinguish the many different kinds of headaches and to determine right treatments for each.

Primary Headaches

A headache is considered primary when it is not caused by a disease or other medical condition. Most primary headaches fall into three main types: tension-type, migraine, and cluster headaches.

Tension headache is the most common primary headache, accounting for 90% of all headaches.

Migraines are the second most frequently occurring primary headaches. Migraine is referred to as a neurovascular headache because it is most likely caused by an interaction between blood vessel and nerve abnormalities.

Cluster headache is a less common type of primary headache. Although it is sometimes referred to as a neurovascular headache, evidence now suggests that its cause may lie in the hypothalamus, a region deep in the brain that regulates, among other functions, the biologic rhythms of the body.

Headaches are usually caused by muscle tension, vascular problems, or both.

Secondary Headaches

Secondary headaches are caused by other medical conditions, such as sinus infections, neck injuries, and strokes. About 2% of headaches are secondary to abnormalities or infections in the nasal or sinus passages, and they are commonly referred to as sinus headaches.

Chronic Daily Headaches

Chronic daily headaches are defined as any benign headache that occurs at least 15 days a month and is not associated with a serious neurologic abnormality. Most people with these headaches have them daily or almost daily and they can be quite debilitating.

Chronic daily headaches are subdivided into two categories:

Short-duration headaches, or those lasting fewer than 4 hours. The most common short-acting chronic headaches are cluster headaches.

Long-duration headaches, which last more than 4 hours. Tension-type headaches are the most common type of long-duration chronic (recurring) headaches and, in fact, the most common type of chronic headaches in general.

Click on the icon to see an image about headaches.

Cluster Headaches

Cluster headaches are among the most painful, and least common, of all headaches. The pain can be so excruciating that they are sometimes referred to as "suicide headaches." Their signature is a pattern of periodic cycles ("clusters") of headache attacks, which may be either:

Episodic. Attacks occur regularly for 1 week to 1 year, separated by long pain-free periods that last at least 1 month. Between 80 - 90% of patients have episodic cycles. A significant number of people who experience a first cluster attack do not have another one.

Chronic. Attacks occur regularly for more than 1 year, with pain-free periods lasting less than 1 month. Between 10 - 20% of patients have chronic cluster headaches. The chronic form is very difficult to treat.

Typical Cluster Cycles

Timing of an Attack. Cluster headache attacks tend to occur with great regularity at the same time of day. (For this reason, cluster headaches are sometimes referred to as "alarm clock" headaches.) About 75% of attacks occur between 9 p.m. - 10 a.m. Attacks may also peak between 1 - 3 p.m.

Duration of an Attack. A single cluster attack is usually brief but extremely painful, lasting about 15 minutes - 1.5 hours if left untreated.

Number of Attacks per Day. During an active cycle, people can experience as few as 1 attack every other day to as many as 8 attacks a day.

Duration of Cycles. Attack cycles typically last 6 - 12 weeks with remissions lasting up to 1 year. In the chronic form, attacks are ongoing, and there is little remission. Attacks cycles tend to occur seasonally, most often in the spring and autumn.

Primary Headaches That Resemble Cluster Headaches

Chronic Paroxysmal Hemicrania. Chronic paroxysmal hemicrania is a close relative of cluster headache and very similar. It causes multiple, short, and severe daily headaches with similar symptoms. Unlike cluster headaches, the attacks are shorter (1 - 2 minutes) and more frequent (occurring an average of 15 times a day). This headache is even rarer than cluster headache, tends to occur in women, and always responds to treatment with the drug indomethacin (Indocin).

Hemicrania Continua. Hemicrania continua occurs mostly in women. The patient generally experiences continuous low-level headache always on one side of the face. Periodic attacks can last days to weeks, which can be mild to severe, and may resemble migraines. (About 10% of patients experience remissions.) The headache can usually be treated successfully with indomethacin, which helps differentiate it from cluster and migraine headaches.

SUNCT Syndrome. A disorder called SUNCT syndrome (short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing) causes stabbing or burning eye pain that may resemble cluster headaches, but attacks are very brief (lasting about a minute) and may occur more than 100 times per day. Red and watery eyes, sweating forehead, and congestion are typical. This rare headache is more common in men and does not respond to other headache treatments.

Causes

Cluster headaches, like migraines, are likely due to an interaction of abnormalities in the blood vessels and nerves that affect regions in the face.

Abnormalities in the Hypothalamus

Evidence strongly suggests that abnormalities in the hypothalamus, a complex structure located deep in the brain, may play a major role in cluster headaches. Advanced imaging techniques have shown that a specific area in the hypothalamus is asymmetrical in these patients and is activated during a cluster headache attack.

The hypothalamus is involved in the regulation of many important chemicals and nerve pathways, including:

Serotonin and norepinephrine. These are neurotransmitters (chemical messengers in the brain) that are involved with well-being and appetite.

Cortisol (stress hormones)

Melatonin (a hormone related to the body's response to light and dark)

Beta-endorphins (substances that modulate pain)

By some not completely understood mechanism, the trigeminal nerve is also involved. The trigeminal nerve carries sensations from the face to the brain.

Circadian Abnormalities. Cluster attacks often occur during specific sleep stages. They also often follow the seasonal increase in warmth and light, beginning in summer and ending in the fall. Researchers have therefore focused attention on circadian rhythms, and in particular small clusters of nerves in the hypothalamus that act like biologic clocks. The hormone melatonin is also involved in the body's biologic rhythms.

Dilation of Blood Vessels

Cluster headaches are associated with dilation (widening) of blood vessels and inflammation of nerves behind the eye.

Cluster headaches may be caused by blood vessel dilation in the eye area. Inflammation of nearby nerves may give rise to the distinctive stabbing, throbbing pain usually felt in one eye. The trigeminal nerves branch off the brainstem behind the eyes and send impulses throughout the cranium and face.

What causes these events and how they relate to cluster headaches are still unclear. Because blood vessel dilation appears to follow, not precede, the pain, some action originating in the brain is likely to be part of the primary process.

Abnormalities in the Sympathetic Nervous System

Some evidence suggests that abnormalities in the sympathetic (also called autonomic) nervous system may contribute to cluster headaches. This system regulates non-voluntary muscle actions in the body, such as in the heart and blood vessels.

Prognosis

The pain of cluster headaches can be intolerable. In fact, a higher-than-average rate of suicide has been reported in men with these headaches. Eventually, as people age, the attacks cease, but doctors cannot predict when or how they will end.

Effects on Mental and Emotional Functioning

Anxiety and depression are common among people with cluster headaches, which can affect functioning and quality of life.

Auras and Medical Risks

About 14% of patients with cluster headaches have migraine-like aura. Recent research suggests that headaches that are accompanied by aura may increase the risk of stroke or transient ischemic attack (TIA). TIA symptoms are similar to those of stroke, but last only briefly. A TIA is often a warning sign that a person is at risk for having a more severe stroke. Headaches with auras may also increase the risk for eye retinal damage (retinopathy). Aura-related headaches may affect the small blood vessels in the brain and the eyes, thereby increasing the risks for stroke and retinopathy.

Risk Factors

Cluster headaches are rare, affecting less than 1% of the population.

Age and Gender

Cluster headaches can affect all ages, from children to the elderly, but are most common from young adulthood through middle age. Men are 2 - 3 times more likely to have cluster headaches than women, with the peak age of onset occurring during their 40s. In women, age of onset tends to be in the 60s.

Unlike with migraines, fluctuations in estrogen and other female hormones do not appear to influence the onset of attacks in women.

Lifestyle Factors

Lifestyle factors, including smoking, alcohol abuse, and stress (in particular stressful work situations), appear to play a very strong role in cluster headaches. Smoking can trigger attacks. (However, quitting smoking generally does not have an effect on the disease course.) Alcohol, most commonly red wine, may trigger an attack.

Family History and Genetic Factors

Cluster headaches tend to run in families, suggesting a genetic component may be involved in some cases.

History of Migraine

About half of people with cluster headache have a personal or family history of migraine. Studies have reported that about 15% of patients have both kinds of headache.

Head Injury

Head injury with brain concussion appears to increase the risk of cluster headaches, although a causal relationship has not been proven.

Sleep Apnea and Other Sleep Disorders

Cluster headaches tend to occur during specific sleep stages and have been associated with several sleep disorders, including narcolepsy, insomnia, and sleep apnea.

Sleep apnea, a disorder in which a person's breathing pauses during the night, perhaps hundreds of times, is of particular interest. In some people, apnea may trigger a cluster headache during the first few hours of sleep, making patients susceptible to follow-up attacks during the following midday to afternoon periods. Treating patients who have both disorders with a device called CPAP, which opens the airways, may help improve both conditions. [For more information, see In-Depth Report #65: Sleep apnea.]

Cluster Headache Triggers

The following conditions and substances might trigger cluster attacks:

Alcohol and cigarette smoking

High altitudes (trekking, air travel)

Bright light (including sunlight)

Exertion

Heat (hot weather, hot baths)

Foods high in nitrites (such as bacon and preserved meats)

Certain medications (including those that cause blood vessel dilation, such as nitroglycerin, and various blood pressure medications)

Cocaine

Triggers usually have an effect only during active cluster cycles. When the disorder is in remission, such triggers rarely set off the headaches.

Symptoms

Symptoms

Cluster headaches usually strike suddenly and without warning, although some people have a migraine-type aura before the attack. The pain is deep, constant, boring, piercing, or burning in nature, and located in, behind, or around the eye. The pain then spreads to the forehead, jaw, upper teeth, temples, nostrils, shoulder or neck. The pain and other symptoms usually remain on one side of the head.

The pain generally reaches very severe levels within 15 minutes. Patients may feel agitated or restless during an attack and often want to isolate themselves and then move around. Gastrointestinal symptoms are not very common.

Other typical symptoms include:

Swollen or droopy eyelid

Watery, tearing eye

Contraction of the eye pupil

Stuffy or runny nose

Forehead and facial sweating

Restlessness and agitation

Nausea and vomiting

Intolerance to light and sound

The symptoms of a cluster headache include stabbing severe pain behind or above one eye or in the temple. Tearing of the eye, congestion in the associated nostril, and pupil changes and eyelid drooping may also occur.

Diagnosis

Many patients report a delay of 1 - 6 years in the diagnosis of their cluster headaches. Migraine-like symptoms (light and sound sensitivity, aura, nausea, vomiting) are major reasons for the frequent misdiagnosis by primary care doctors. In some cases, patients are inappropriately treated for other types of headaches or health conditions (including having sinus surgery).

Medical and Personal History

Cluster headache is diagnosed by medical history, including the pattern of recurrent attacks, and by typical symptoms (swollen eyelid, watery eye, runny nose). Keeping a headache diary to record a description of attacks can help the doctor make an accurate diagnosis. The patient should describe to the doctor:

Frequency of attacks (if keeping a diary, record the date and time of each attack)

Description of pain (stabbing, throbbing)

Location of pain

Duration of pain

Intensity of pain (using a number scale like the one below)

Associated symptoms (tearing eyes, nausea and vomiting, sweating)

Any measures that bring relief (applying pressure, going out for fresh air)

Any events that preceded or may have triggered the attack

Any medications you are taking

Behaviors during a headache (restlessness, agitation)

Snoring, sleep disturbances, or daytime sleepiness (these could relate to sleep apnea, which is sometimes associated with cluster headache)

Pain may be indicated by using a number system:

1 = Mild, barely noticeable

2 = Noticeable, but does not interfere with work or activities

3 = Distracts from work or activities

4 = Makes work or activities very difficult

5 = Incapacitating

Physical Examination

To diagnose a chronic headache, the doctor will examine the head and neck and perform a neurologic examination, which includes a series of simple exercises to test strength, reflexes, coordination, and sensation. The doctor may also examine the eyes. The doctor may ask questions to test short-term memory and related aspects of mental function.

Imaging Tests

The doctor may order a computed tomography (CT) scan or magnetic resonance imaging (MRI) test of the head to check for brain abnormalities that may be causing the headaches.

Ruling Out Other Headaches and Medical Disorders

As part of the diagnosis, a doctor should rule out other headaches and disorders. If the results of the history and physical examination suggest other or accompanying causes of headaches or serious complications, extensive imaging tests are performed.

Migraines. Cluster headaches are often misdiagnosed as migraines but they are quite different:

Frequency and Duration. Cluster headaches generally last 15 minutes to a few hours and can occur several times a day. A single migraine attack is continuous over the course of one or several days.

Behavior. Cluster headache sufferers tend to move about while migraine sufferers usually want to lie down.

Nevertheless, in both cases, the headache suffers can be highly sensitive to light and noise, which may make it difficult to distinguish between them.

Other Headaches. Other headaches that resemble migraines include SUNCT (short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing) and chronic paroxysmal hemicrania, which are other primary headaches, and some secondary headaches notably trigeminal neuralgia (TN), temporal arteritis, and sinus headaches. Cluster symptoms, however, are usually precise enough to rule out these other types of headaches.

Tear in the Carotid Artery. A tear in the carotid artery (which carries blood to the brain) can cause pain that resembles a cluster headache. People with this condition may even respond to sumatriptan, a drug used to treat a cluster attack. Doctors should consider imaging tests for patients with a first episode of cluster headache in which this event is suspected.

Orbital Myositis. An unusual condition called orbital myositis, which produces swelling of the muscles around the eye, may mimic symptoms of cluster headache. This condition should be considered in patients who have unusual symptoms such as protrusion of the eyeball, painful eye movements, or pain that does not dissipate within 3 hours.

Headache Symptoms that Could Indicate Serious Underlying Disorders

Headaches indicating a serious underlying problem, such as cerebrovascular disorder or malignant hypertension, are uncommon. (It should be emphasized that a headache is not a common symptom of a brain tumor.) People with existing chronic headaches, however, might miss a more serious condition believing it to be one of their usual headaches. Such patients should immediately call a doctor if the quality of a headache or accompanying symptoms has changed. Everyone should call a doctor for any of the following symptoms:

Sudden, severe headache that persists or increases in intensity over the following hours, sometimes accompanied by nausea, vomiting, or altered mental states (possible indication of hemorrhagic stroke, which is also called brain hemorrhage).

Sudden, very severe headache, worse than any headache ever experienced (possible indication of brain hemorrhage or a ruptured aneurysm).

Chronic or severe headaches that begin after age 50.

Headaches accompanied by other symptoms, such as memory loss, confusion, loss of balance, changes in speech or vision, or loss of strength in or numbness or tingling in arms or legs (possibility of small stroke in the base of the skull).

Headaches after head injury, especially if drowsiness or nausea are present (possibility of brain hemorrhage).

Headaches that increase with coughing or straining (possibility of brain swelling).

A throbbing pain around or behind the eyes or in the forehead accompanied by redness in the eye and perceptions of halos or rings around lights (possibility of acute glaucoma).

A one-sided headache in the temple in elderly people; the artery in the temple is firm and knotty and has no pulse; scalp is tender (possibility of temporal arteritis, which can cause blindness or even stroke if not treated).

Sudden onset and then persistent, throbbing pain around the eye possibly spreading to the ear or neck unrelieved by pain medication (possibility of blood clot in one of the sinus veins of the brain).

Managing Cluster Headaches

Management of cluster headaches focuses on:

Acute therapy for stopping an attack while it is happening

Preventive therapy for stopping or reducing attack recurrences

Treating Attacks

The most effective and best-studied treatments for a cluster attack are:

Oxygen inhalation.

Triptan drugs. Usually an injection of the triptan drug sumatriptan (Imitrex, generic), which is FDA-approved for cluster headache treatment. Intranasal formulations of sumatriptan or zolmitriptan (Zomig) are alternatives.

Relief can occur in 5 - 10 minutes. Oxygen and sumatriptan injection are sometimes given together.

Other drugs that may be used for acute attacks are nasal sprays of dihydroergotamine or lidocaine.

Preventing Attacks

Cluster headache attacks are usually short, lasting from 15 - 180 minutes, and the excruciating pain may have subsided by the time a patient reaches a doctor’s office or emergency room.

Because it can be difficult to treat attacks when they occur, treatment efforts focus on the prevention of attacks during cluster cycles. Although certain drugs are standard, preventive therapy needs to be individually tailored for each patient. The doctor may prescribe a combination of drugs.

Verapamil (Calan, generic), a calcium-channel blocker drug, is the mainstay preventive treatment for cluster headaches. However, it can take 2 - 3 weeks for this drug to take effect. During this period, corticosteroids (typically prednisone) may be used as an initial transitional therapy. For long-term treatment of chronic cluster headaches, lithium may be used as an alternative to verapamil.

Although they are not FDA-approved for cluster headache, anti-seizure drugs such as valproate (Depakote, generic), valproic acid (Depakene, generic), topiramate (Topamax, generic), and gabapentin (Neurontin) are sometimes used for preventive treatment.

Behavioral Treatments and Lifestyle Changes

Behavioral Treatments. Behavioral therapies can be a helpful accompaniment to drug treatment. These approaches can help with pain management and enable patients to feel more in control of their condition.

Behavioral approaches include:

Relaxation treatment combined with biofeedback

Cognitive-behavioral therapy

Lifestyle Changes. Patients should avoid the following triggers that may provoke cluster headache attacks:

Alcohol. Heavy alcohol use is strongly associated with cluster headaches, although it is not clear if alcohol triggers pain or is simply used as a coping mechanism for dealing with severe pain.

Cigarette smoking. Many studies indicate that a majority of patients with cluster headache are cigarette smokers. While studies have not shown that quitting cigarettes will stop cluster headaches, smoking cessation should still be a goal. Smokers who can't quit should at least stop at the first sign of an attack and not smoke throughout a cycle.

Treatment for Acute Attacks

Oxygen Therapy

Breathing pure oxygen (by face mask, for 15 minutes or less) is one of the most effective and safest treatments for cluster headache attacks. It is often the first choice treatment. Inhalation of oxygen raises blood oxygen levels, therefore relaxing narrowed blood vessels.

Triptans

Triptans are drugs that are usually used to treat migraine headaches. They can also help stop a cluster attack. An Injection of sumatriptan (Imitrex, generic) is the standard triptan treatment and is FDA-approved for cluster headaches. Sumatriptan injections work within 15 minutes in about three quarters of most cluster attacks. The nasal spray form may also be effective for some patients, and generally provides relief within 30 minutes. The spray seems to work best for attacks that last at least 45 minutes, although some people find it does not work as well as the injectable form.

Zolmitriptan (Zomig) is another triptan drug used for cluster headache treatment. It is given in either oral or nasal spray form. Zolmitriptan may have fewer side effects than sumatriptan.

Side Effects. Side effects of sumatriptan may include:

Nausea

Dizziness

Muscle weakness

Heaviness or pressure in the chest

Tingling and numbness in the toes

Rapid heart rate

Complications and Contraindications of Triptans. The following are potentially serious problems with triptans:

Complications on the Heart and Circulation. Triptans narrow (constrict) blood vessels. Because of this action, spasms in the blood vessels may occur, which can cause stroke and heart attack. This is a rare but very serious side effect. Patients with a history of heart attack, stroke, angina, uncontrolled high blood pressure, peripheral artery disease, or heart disease should not use triptan drugs.

Serotonin Syndrome. Serotonin syndrome is a life-threatening condition that occurs from an excess of the brain chemical serotonin. Triptans, as well as certain types of antidepressant medications, can increase serotonin levels. These antidepressant drugs include serotonin reuptake inhibitors (SSRIs) such as fluoxetine (Prozac, generic), paroxetine (Paxil, generic), and sertraline (Zoloft, generic) and selective serotonin/norepinephrine reuptake inhibitors (SNRIs) such as duloxetine (Cymbalta) and venlafaxine (Effexor, generic). It is very important that patients not combine a triptan drug with an SSRI or SNRI drug. Serotonin syndrome is most likely to occur when starting or increasing the dose of a triptan or antidepressant drug. Symptoms include restlessness, hallucinations, rapid heartbeat, tremors, increased body temperature, diarrhea, nausea, and vomiting. You should seek immediate medical care if you have these symptoms.

Ergotamine

Injections of the ergotamine-derived drug known as dihydroergotamine (DHE, Migranal) can stop cluster attacks within 5 minutes in many patients, offering benefits similar to injectable sumatriptan. Ergotamine is also available in the form of a nasal spray, rectal suppositories, and tablets.

Ergotamine can have dangerous drug interactions with many medications, including sumatriptan. All ergotamine products approved by the Food and Drug Administration (FDA) contain a "black box" warning in the prescription label explaining these drug interactions. Because ergotamine constricts blood vessels, patients with peripheral vascular disease should not use this drug.

Local Anesthetics

Lidocaine, a local anesthetic, may be useful in nasal-spray or nasal-drop form for stopping cluster attacks. Reports suggest that it is helpful for most patients within about 40 minutes. It can have an unpleasant taste. Some doctors recommend that patients try a topical application of lidocaine to see if it helps ease pain.

Capsaicin is a compound derived from hot pepper. Some patients who have not found relief through other medications use it to treat or prevent cluster headaches by applying it intranasally. There have been few studies to confirm its effectiveness. It can cause an intense burning sensation.

Preventive Medications

Calcium-Channel Blockers

Calcium-channel blockers, commonly used to treat high blood pressure and heart disease, are important drugs for preventing episodic and chronic cluster headaches. Verapamil (Calan, generic) is the standard calcium-channel blocker used for cluster headache prevention. It can take 2 - 3 weeks to have a full effect, and a corticosteroid drug may be used in combination during this transitional period. Constipation is a common side effect.

Lithium

Lithium (Eskalith, generic), commonly used for bipolar disorder, may also help prevent cluster headaches. The patient usually receives benefit within 2 weeks of starting to take the drug, and often within the first week. Lithium may be used alone or with other drugs. Lithium can have many side effects including trembling hands, nausea, and increased thirst. Weight gain is a common side effect with long-term use. [For more information, see In-Depth Report #66: Bipolar disorder.]

Corticosteroids

Corticosteroid drugs (also called steroids) are very useful as transitional drugs for stabilizing patients after an attack until a maintenance drug, such as verapamil, begins to take effect. Prednisone (generic) and dexamethasone (Decadron, generic) are the standard steroid drugs used for short-term cluster headache transitional treatment. These drugs are typically taken for a week and then gradually tapered off. If headaches return, the patient may start taking the steroid again. Unfortunately, long-term use of steroids can lead to serious side effects so they cannot be taken for on-going prevention.

Steroid injections may also provide short-term relief. Some patients are helped by an occipital nerve block in which an anesthetic and a corticosteroid are injected into the occipital nerve in the back of the head. Researchers are also investigating suboccipital injections where a steroid is injected into the base of the skull on the same side as the headache attack.

Anti-Seizure Drugs

Anti-seizure drugs, which are used for epilepsy treatment, may be helpful for preventing cluster headaches in some patients. They include older drugs such as divalproex (Depakote, generic), valproic acid (Stavzor, Depakene, generic) and newer drugs such as topiramate (Topamax, generic) and gabapentin (Neurontin, generic). More research needs to be done to evaluate how effective these drugs are at preventing cluster headaches.

Side Effects. Anti-seizure medication side effects vary by drug but may include:

Nausea and vomiting

Diarrhea

Cramps

Tingling sensation in arms and legs

Hair loss

Dizziness

Sleepiness

Blurred vision

Weight gain (or with topiramate, weight loss)

Valproate and divalproex can cause serious side effects of inflammation of the pancreas (pancreatitis) and damage to the liver

Divalproex sodium, valproic acid, and topiramate can increase the risk for birth defects, particularly cleft palate. These drugs should not be used during the first trimester of pregnancy. Women who are of child-bearing age and considering pregnancy should discuss the safety of these drugs with their doctors and consider other types of migraine preventive medication.

All anti-seizure drugs may increase the risks of suicidal thoughts and behavior (suicidality). The highest risk of suicide can occur as soon as 1 week after beginning drug treatment and can continue for at least 24 weeks. Patients who take these drugs should be monitored for signs of depression, changes in behavior, or suicidality. [For more information, see In-Depth Report #44: Epilepsy.

Investigational Drugs

Botulinum. Botulinum toxin A (Botox) injections are typically used to smooth wrinkles. Botox is also being studied for treatment of headaches, including the prevention of cluster headaches. Research is still preliminary, and there is not sufficient evidence to support its efficacy.

Melatonin. Small reports indicate that melatonin, a brain hormone that helps to regulate the sleep-wake cycle, may help prevent episodic or chronic cluster headaches. Melatonin supplements are sold in health food stores, but as with most natural remedies, the quality of different preparations varies, and they have not been rigorously tested for safety or effectiveness. More studies are needed.

Surgery

In rare cases, surgical intervention may be considered for patients with chronic cluster headaches that do not respond to other treatments. Patients whose headaches have not gone into remission for at least a year may also be candidates for surgery. Most surgical approaches for cluster headache are still considered experimental, having been tested only on a relatively small number of patients. Surgery has shown limited success and can have distressing side effects. However, some surgical techniques, such as deep brain electrical stimulation, are showing promise.

Deep Brain Electrical Stimulation

Deep brain stimulation (also called neurostimulation) may relieve chronic cluster headaches in some patients who do not respond to drug therapy. A similar technique is approved for treating the tremors associated with Parkinson's disease. The surgeon implants a tiny wire in a specific part of the hypothalamus. The wire receives electrical pulses from a small generator implanted under the collarbone.

Although only a small number of patients have been treated, results to date are promising. Some patients have remained completely free of pain for an average of more than 7 months when the electrode is switched on. When the device is turned off, headaches reappear within days to weeks. The procedure is reversible and appears to be generally safe, although a few cases of fatal cerebral hemorrhage have occurred.

Occipital Nerve Stimulation

Occipital nerve stimulation is being investigated as a less invasive and less risky alternative to deep brain hypothalamus stimulation. Recent studies have reported promising results in a small group of patients with cluster headaches. Some patients became pain-free, while others had reduced frequency of headache attacks.

Vagus Nerve Stimulation

The vagus nerve runs between the brain and the abdomen. Vagus nerve stimulation (VNS) is a surgical procedure in which a small generator is placed under the skin on the left side of the chest. A surgeon makes a second incision in the neck and connects a wire from the generator to the vagus nerve. A doctor programs the generator to send mild electrical pulses at regular intervals. These pulses stimulate the vagus nerve.

VNS is sometimes used to treat epilepsy and depression that does not respond to drugs. It is also being investigated as a possible treatment for chronic migraine and cluster headaches.

Procedures to Block or Remove Facial Nerves That Cause Pain

Percutaneous Radiofrequency Retrogasserian Rhizotomy. Percutaneous radiofrequency retrogasserian rhizotomy (PRFR) generates heat to destroy pain-carrying nerve fibers in the face. Unfortunately complications are common and include numbness, weakness during chewing, changes in tearing and salivation, and facial pain. In severe, but rare, cases, complications include damage to the cornea and vision loss.

Percutaneous Retrogasserian Glycerol Rhizolysis. Percutaneous retrogasserian glycerol rhizolysis (PRGR) is a less invasive technique than PRFR and has fewer complications. It involves injections of glycerol to block the facial nerves that cause the pain. Cluster headaches usually recur.

Microvascular Decompression of the Trigeminal Nerve. Microvascular decompression frees the trigeminal nerve from any blood vessels that are pressing against it. The procedure is risky, and possible complications include nerve and blood vessel injury and spinal fluid leakage. There is reasonably good evidence that it is not effective for treatment of cluster headaches.