Stroke Program, Department of Neurology, and Department of Internal Medicine, University of Michigan, Ann Arbor; Departments of Biostatistics and Epidemiology, University of Michigan School of Public Health, Ann Arbor; and Ann Arbor VA Healthcare System and VA HSRD Center of Excellence, Ann Arbor, MI.

Abstract

BACKGROUND:

The prevalence of severe obesity is rising in the United States. Although mild to moderately elevated body mass index (BMI) is associated with reduced mortality after acute ischemic stroke, less is known about severe obesity.

METHODS AND RESULTS:

Patients with acute ischemic stroke (n=1791) ≥45 years were identified from the biethnic population-based Brain Attack Surveillance in Corpus Christi (BASIC) study from June 1, 2005, to December 31, 2010. Median follow-up was 660 days. BMI was abstracted from the medical record. Survival was estimated by BMI category (underweight, normal weight, overweight, class 1 obesity, class 2 obesity, and severe obesity) using Kaplan-Meier methods. Hazard ratios for the relationship between BMI modeled continuously and mortality were estimated from Cox regression models after adjustment for patient factors. The median BMI was 27.1 kg/m(2) (interquartile range, 23.7-31.2 kg/m(2)), and 56% were Mexican American. A total of 625 patients (35%) died during the study period. Persons with higher baseline BMI had longer survival in unadjusted analysis (P<0.01). After adjustment for demographics, stroke severity, and stroke and mortality risk factors, the relationship between BMI and mortality was U shaped. The lowest mortality risk was observed among patients with an approximate BMI of 35 kg/m(2), whereas those with lower or higher BMI had higher mortality risk.

CONCLUSIONS:

Severe obesity is associated with increased poststroke mortality in middle-aged and older adults. Stroke patients with class 2 obesity had the lowest mortality risk. More research is needed to determine weight management goals among stroke survivors.

Hazard Ratio for Mortality for a 1-kg/m2 increase in BMI across the range of baseline BMI among Patients with Acute Ischemic Stroke (n=1,775): The Brain Attack Surveillance in Corpus Christi (BASIC) Project, June 1, 2005- December 31, 2010