Researchers carried out the first global analysis of genome variation in honeybees. Their findings show a surprisingly high level of genetic diversity in honeybees, and indicate that the species most probably originated from Asia, and not from Africa as believed.

The honeybee (Apis mellifera) is of crucial importance for humanity. One third of our food is dependent on the pollination of fruits, nuts and vegetables by bees and other insects.

Extensive losses of honeybee colonies in recent years are a major cause for concern. Honeybees face threats from disease, climate change, and management practices, researchers said.

To combat these threats it is important to understand the evolutionary history of honeybees and how they are adapted to different environments across the world, they said.

"In contrast to other domestic species, management of honeybees seems to have increased levels of genetic variation by mixing bees from different parts of the world. The findings may also indicate that high levels of inbreeding are not a major cause of global colony losses," said Matthew Webster, researcher at the department of Medical Biochemistry and Microbiology, Uppsala University in Sweden.

Another unexpected result was that honeybees seem to be derived from an ancient lineage of cavity-nesting bees that arrived from Asia around 300,000 years ago and rapidly spread across Europe and Africa. This stands in contrast to previous research that suggests that honeybees originate from Africa.

"The evolutionary tree we constructed from genome sequences does not support an origin in Africa, this gives us new insight into how honeybees spread and became adapted to habitats across the world," said Webster.

Hidden in the patterns of genome variation are signals that indicate large cyclical fluctuations in population size that mirror historical patterns of glaciations. This indicates that climate change has strongly impacted honeybee populations historically.

"Populations in Europe appear to have contracted during ice ages whereas African populations have expanded at those times, suggesting that environmental conditions there were more favourable," said Webster.

The researchers also identified specific mutations in genes important in adaptation to factors such as climate and pathogens, including those involved in morphology, behavior and innate immunity.