Researchers discover potential PCOS cause

"It's by far the most common hormonal condition affecting women of reproductive age but it hasn't received a lot of attention", says Robert Norman at the University of Adelaide in Australia.

Beyond helping women to get pregnant, this is an awesome breakthrough for those frustrated with the side effects from the condition, because they may at long last have relief.

To find out if this excess hormone level was triggering the condition, they injected pregnant mice with anti-Müllerian hormone.

Scientists at the French National Institute of Health and Medical Research measured levels of the hormone in a cohort of pregnant women with and without PCOS.

"These findings highlight a critical role for excess prenatal AMH exposure and subsequent aberrant GnRH receptor signaling in the neuroendocrine dysfunctions of PCOS, while offering a new potential therapeutic avenue to treat the condition during adulthood", the researchers wrote. As their female offspring grew up, they displayed numerous hallmarks of polycystic ovary syndrome, including later puberty, infrequent ovulation, delays in falling pregnant, and fewer offspring. Researchers found that pregnant women with PCOS have 30 percent higher AMH levels than normal, and so they wanted to test if this would induce the same condition in their daughters.

'It's a radical new way of thinking about polycystic ovary syndrome and opens up a whole range of opportunities for further investigation.

Scientists hope to start trials in women within a year - if successful the breakthrough could be good news for PCOS sufferers wanting to have a baby.

Scientists Have Discovered The Cause of Polycystic Ovary Syndrome

Amazingly, when the mice with PCOS were treated with cetrorelix, they stopped exhibiting the symptoms of the condition.

However, more than half of women affected have no symptoms. In this condition, the ovary or ovaries develop multiple fluid-filled sacs that contain immature eggs that do not mature for ovulation.

The excess hormone seemed to overstimulate the set of brain cells that raise up the level of testosterone in mice.

With a new way of looking at PCOS, researchers also thought up a possible treatment for the condition in the form of cetrorelix, an IVF drug that's used to control women's hormones.

Levels of the hormone are known to decline as women get older.

Women with PCOS tend to produce too much insulin, which can cause weight gain or lead to obesity.

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