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I have MS Office 365 and CCleaner Professional v5.58.7209(64bit) installed on a win10 desktop PC.

Recently, in the last couple of months, whenever I run a scan and clean I cannot then use any of the MS Office 365 components. If I try to use Outlook for example I get a notice telling me that the file is corrupt and cannot load. I re-install Office 365 and all is good again. This is happening every time I run CCleaner and I am forced to re-install Office. Whilst I can get it back it's a total PITA and shouldn't be happening.

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try Analyze first and remove one by one what ccleaner detected till you get the Cleaner rule that cause the problem

Report back here your finding

I get that. I did/have logged in to this forum to report a problem LOL

I have run CCleaner a couple of times and had the issue described. I don't have the enhancer or other apps mentioned as my CCleaner is official and downloaded from Piriform. I have unticked anything in CCleaner that reads as MS Office or Office and run CCleaner and the issue persists. I have never run CCleaner Reg cleaner so that won't be the cause I suspect.

I was rather hoping there would be an easy and known fix but it appears I'm alone in this situation. I've been using CCleaner Professional for many years and this problem has only just appeared so I'm a tad confused. Understand I appreciate your time and effort on my behalf.

Easy Clean uses default cleaning actions set by Piriform, - I'm not sure if that includes Office products by default or not.

AFAIK Piriform have not yet published information on just what the Easy Clean defaults are.
Easy Clean is not even mentioned in the CCleaner documentation yet.

We have seen previously that for unticked boxes to have effect (and so not clean Office?) then you need to Ananlyze/Clean using Custom Clean rather than Easy Clean.
ie. Easy Clean does not respect your Custom Clean ticks/unticks, it only uses it's own default settings.

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Easy Clean uses default cleaning actions set by Piriform, - I'm not sure if that includes Office products by default or not.

AFAIK Piriform have not yet published information on just what the Easy Clean defaults are.
Easy Clean is not even mentioned in the CCleaner documentation yet.

We have seen previously that for unticked boxes to have effect (and so not clean Office?) then you need to Ananlyze/Clean using Custom Clean rather than Easy Clean.
ie. Easy Clean does not respect your Custom Clean ticks/unticks, it only uses it's own default settings.

I use custom clean with all/any references to MS Office or Office disabled. I've never used the Easy Clean.

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Oh well, it was just a thought as we have seen similar before when a user had unticked some options but EasyClean was still removing them.

As dvdbane suggests your best option is to do an Analyze and list the files found to see which relate to Office. (use the Advanced listing).

You can then right click anything related to Office and 'Add to Exclude list' then try cleaning again.

If that doesn't work then you will need to look at what else CC is finding to remove and work out (exclude them one-by-one) which file deletion is causing the problem.
It can be time consuming, especially if more than one file is involved.

You could further refine it by only Analyzing for Office files to see which ones CC is finding to clean.
Use option 1 above then:
In the 'Applications' Tab right click on 'Office ####' and select Analyze in the pop-up. (That will only list what files CC finds to clean for that version of Office and nothing else).

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Interesting issue. The CCleaner team all use Office and have yet to brick themselves. If you run an analysis first with Office checked (would be under Custom Clean > Applications > Applications) ...

... and then right-click "View all Files" you should see a list of cache and temp files and some recent file LNKs - but nothing mission critical.

Under Custom Clean > Windows > System, do you have "Start Menu Shortcuts" and "Desktop Shortcuts" unchecked? Might not be the install itself at (C:\Program Files\Microsoft Office\root\Office16\outlook.exe) but just the shortcuts being mangled?

You could further refine it by only Analyzing for Office files to see which ones CC is finding to clean.
Use option 1 above then:
In the 'Applications' Tab right click on 'Office ####' and select Analyze in the pop-up. (That will only list what files CC finds to clean for that version of Office and nothing else).

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Selecting Options>Advanced> Cleaning results level of detail>Advanced report gives a report like this which shows the sections to be cleaned and how many files are in each section:

(Note Firefox was skipped because I have it open).

Selecting Options>Advanced> Cleaning results level of detail>File List gives a report like this which shows the actual individual files:
(There is no number of files, each one is a single file).

Yes I understand this and I now have tried both settings and analyzed with each. With Office ticked in the applications section the results show a shed load of files to be cleaned. With Office unticked no mention of Office appears in the results to be cleaned. Run CCleaner, restart PC, open any Office product to be met with a notice telling the files are corrupted, or similar and it won't open. I have to reinstall Office 365 for it to work. All settings and emails etc are as was but a reinstall is required to use Office.

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To get a list of exactly what is being removed (without actually cleaning it) can I get you to try ....

Custom Clean > Analyze using your current settings

Right-click on the "Analysis Complete" text and select "Save to text file". You should end up with a file called log.txt with a summary header block and then a list of all of the files that CCleaner is proposing to clean - should look something like this:

... and then either post it here for us to take a look at or, if there is any sensitive or personally identifying information in there that you'd rather not reveal publicly, DM it to me privately instead.

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To get a list of exactly what is being removed (without actually cleaning it) can I get you to try ....

Custom Clean > Analyze using your current settings

Right-click on the "Analysis Complete" text and select "Save to text file". You should end up with a file called log.txt with a summary header block and then a list of all of the files that CCleaner is proposing to clean - should look something like this:

... and then either post it here for us to take a look at or, if there is any sensitive or personally identifying information in there that you'd rather not reveal publicly, DM it to me privately instead.

Strangely, by pure coincidence,............ surely not!

Yesterday CCleaner offered two updates one very soon after the other. This morning Windows prompted a restart due to an update. So I updated CCleaner twice yesterday and before restarting in order to update Windows I ran CCleaner. Ran it as I always have done without any Office products ticked on a Custom Clean. Then restarted, Windows update installed and ran Office Outlook followed by Word and then Excel. Without issue they all opened as they should without any notifications of corruptions of any sort. Coincidence or updates fixing things? I don't know but I will plod on and keep a close eye on things. Any issues I will report back here.

Please accept my humble gratitude to those that have got involved and tried to help me with this rather frustrating glitch.

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I've confirmed that CCleaner PRO does corrupt OFFICE 2016 and thus I had to do a reinstall of OFFICE 2016. I've run CCLEANER pro and then clicked on OFFICE 2016 products and sure enough, files were corrupted. Did reinstall of OFFICE 2016,,,,,,,,,ensured the office products were all shut down, ran ccleaner pro again, and once again files were corrupted. Not using CCleaner PRO until i'm told there's a fix for this issue.