MIDAS involves an assessment of glucose levels obtained before and after bariatric surgery. There are two different procedural tests involved; an oral glucose tolerance test (mixed meal) and a hyperglycemic clamp test. Two tests are performed preoperatively and five more are performed postoperatively for a one year period. The associated labwork drawn with the mixed meal and clamp tests are demonstrating changes in glucose, insulin and gut hormone levels.

To assess the effect of gastric by-pass surgery to decrease lipotoxicity. [ Time Frame: One year ] [ Designated as safety issue: Yes ]

Secondary Outcome Measures:

To examine the effect of roux-en-Y compared to gastric banding on pancreatic B cell recovery or insulin secretion in response to oral and IV glucose. [ Time Frame: One Year ] [ Designated as safety issue: Yes ]

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Please refer to this study by its ClinicalTrials.gov identifier: NCT00488423