CNS active drugs: Use with caution with other CNS active drugs. It should not be used with MAOIs. Atleast 2-weeks should elapse between discontinuation of a MAOI and initiation of treatment with sibutramine.
Drugs that may raise blood pressure and/or heart rate: Caution should be used when prescribing sibutramine to patients who use these medications.
Drugs that inhibit cytochrome P450 (3A4) metabolism (Erythromycin, ketoconazole): Concomitant administration of these drugs with sibutramine is not recommended since there is a potential for interaction.
Cimetidine: Efficacy of cimetidine enhanced.
Alcohol: Concomitant use with alcohol is not recommended.
Oral contraceptives: Sibutramine does not inhibit suppression of ovulation by oral contraceptives.

Servings:

Oral: 10mg once daily with or without food. Dose may increase to 15mg daily after 4 weeks if weight loss is inadequate. Patients who don`t tolerate the 10mg dose may receive 5mg daily. Should not use doses above 15mg daily.