In an alternate timeline in which Nazi Germany had invaded the United States, as of 1944 South Carolina was controlled by German forces. A section of the state was a border area between the German and American forces. (ENT: "Storm Front", "Storm Front, Part II")

South Carolina was identified as So. Carolina on a map of the United States (Die Vereinigten Staaten von Amerika). The contours of this state were seen in a map of the United States in "Little Green Men".