When see such a problem, unplug and replug the tablet, then reset the driver or restore previously saved settings (Wacom Desktop Center -> Backup Settings -> Restore). Make sure to use the latest driver (6.3.20-8 at the moment).

wacom1 wrote:When see such a problem, unplug and replug the tablet, then reset the driver or restore previously saved settings (Wacom Desktop Center -> Backup Settings -> Restore). Make sure to use the latest driver (6.3.20-8 at the moment).

Users shouldn't be expected to do this every time!! Sort the drivers out!

I'm on MacOS Mojave 10.14.3 and this just happened to my Large Intuos4 tablet running Driver Version 6.3.32-4.Was working in clip studio paint when MacOs pinged me with an update notification in the corner, which killed mouse movement. Was pressing pen down at that moment.