Welcome to the II International CTERP Conference. It meets the most acute demands of the burgeoning research activities both in novel cell therapy methods and disease mechanism understanding — iPSC, neurobiology, disease modelling, genome editing.

Recently passed law on cell technologies in Russia opens new perspectives for cell technology practical application but also calls for careful understanding of regulation requirements. Regulatory aspects in Russia and abroad will be discussed on the round table.

Professor at the Center for Developmental Genetics of Stony Brook UniversityAdjunct Professor at Cold Spring Harbor LaboratoryAdjunct Professor at Moscow Institute of Physics and Technology

Graduated in neurobiology and molecular biology from Moscow State University. Received his Ph.D. at the Institute of Molecular Biology in Moscow. Worked at the Institute of Molecular Biology, with training at the University of Zurich. Since 1989 worked at Cold Spring Harbor Laboratory, before recently joining Stony Brook University.

Doctor of Science in Biology Novosibirsk State University, SB RAS Institute of Chemical Biology and Fundamental MedicineHeads the Laboratory of Genome and Protein Engineering at SB RAS Institute of Chemical Biology and Fundamental MedicineDirector of the Interdisciplinary Center for Advanced Biomedical Research at Novosibirsk State University

2015 - Russian Academy of Sciences Professorship.

2015 - Russian Foundation for Basic Research Certificate of Honor for contribution to the development of science.

2014 - Novosibirsk State University Certificate of Honor for lifetime contribution for the benefit of the University.

2009 - Prize of the Government of Novosibirsk Region for achievements in science and technology.

Obtained a PhD in 1998 from the Stony Brook University, USA. From 1998 to 2001, he was a postdoc at the Department of Pharmacological Sciences, Stony Brook University and worked as a visiting scientist at the Weizmann Institute of Science, Israel. During his career, Dr. Zharkov contributed to the discovery of several DNA repair enzymes and understanding their mechanism of action through biochemical, structural, and computational studies.Presently, he heads the Laboratory of Genome and Protein Engineering at SB RAS Institute of Chemical Biology and Fundamental Medicine, and is the director of the Interdisciplinary Center for Advanced Biomedical Research at Novosibirsk State University (NSU). He teaches Molecular Biology and Molecular Pharmacology at NSU.

Design of enzymes and protein/nucleic acid systems with predicted functions and properties.

Development of new tools for genome editing

Professional membership:

European Environmental Mutagen Society

Russian Biochemical Society

Yu. A. Ovchinnikov's Russian Society of Biotechnologists

Moscow, Russia

Sergei Nedospasov

Doctor of Biological SciencesProfessorCorresponding Member of the Russian Academy of SciencesAcademician of the Russian Academy of SciencesHead of the Laboratory of Molecular Mechanisms of Immunity of the Institute of Molecular Biology, RASHead of the Department of Molecular Immunology, Institute of Physico-Chemical Biology, RASHead of the Department of Immunology, Biological Faculty, Moscow State University. Scientific Supervisor of the Laboratory of Experimental Immunology of the Center for Molecular Biology and Biomedicine, Institute of Biology and Biomedicine, Nizhny Novgorod State University

Graduated from Faculty of Molecular and Chemical Physics, Department of Molecular Biophysics.

From 1976 he worked in the laboratory of Acad. G.P. Georgieva in the Institute of Molecular Biology. Engelhardt of the Russian Academy of Sciences, then headed a scientific group and a laboratory at the same Institute.

In MSU - since 1996 (Institute of Physico-Chemical Biology named after AN Belozersky).

From 1995 to 2010 - International Research Scholar Medical Institute. Howard Hughes.

In 1980 he defended his Ph.D. thesis, in 1990 he obtained his doctoral thesis.

Since 1998, Professor. He is in charge of the Laboratory of Molecular Mechanisms of Immunity of the Institute of Molecular Biology, Russian Academy of Sciences. V. A. Engelhardt.

Russian biologist, an expert in molecular biology and genetics, immunology and biotechnology. One of the top 100 most cited Russian scientists.

He organized educational programs in Moscow on oncoimmunology and molecular immunology. Made a major contribution to the development of domestic molecular biology, immunology and biomedicine. He and his school carried out pioneering work on the biology of cytokines, created unique animal models of human diseases, investigated the mechanisms of pathogenesis of a number of diseases at the molecular level, developed new approaches to biotherapy, including the creation of prototypes for new drugs.In the 80 years, SA Nedospasov and colleagues were the first to molecularly clone the genes of the tumor necrosis factor (TNF) family of cytokines, which are the mediators of immune processes. Based on these molecular clones, cytokine production strains have been created in our country, including TNF and human lymphotoxin, and then a panel of monoclonal antibodies that neutralize their activity. SA Nedospasov and colleagues created a unique panel of mouse lines with controlled deactivation of TNF, lymphotoxin and other mediators important for the development of the immune system. In these animals it became possible to model various human diseases - from autoimmune and infectious to oncological, to study the association of microbiota with inflammation, and also to practice biotherapy.

Published more than 200 articles, including in the leading international journals (Science, Nature, Immunity, Blood, etc.).

Member of the editorial boards of international and domestic journals: European Journal of Immunology, Journal of Inflammation, Immunology Letters, Molecular Biology, Russian Immunological Journal, Medical Immunology, Cytology.

Scientific interests:

mechanisms of innate immunity

physiology of cytokines

genetic knockout in mice and mouse models of human diseases

cancer antigens

Awards

Investigator Award of the Institute of Cancer Research (USA, 1991)

Prize of the Berlin-Brandenburg Academy of Sciences (Germany, 2000)

The Helmholtz-Humboldt Prize (2005)

Elected a member of the European Academy (2010), the European Academy of Oncoimmunology (2012)

II Mechnikov Prize (2011) - For the cycle of scientific works "Molecular-cellular mechanisms of organization of human and mouse lymphoid organs" (jointly with AA Yarilin).

The State Prize of the Russian Federation (2015) - for a series of fundamental and applied works on the study of molecular mediators of immunity, including works on the creation of unique biomedical models.

PhD FRCPath FRSB Professor of Cell & Tissue Therapy at University College London Director of the Centre for Cell, Gene & Tissue Therapeutics Honorary Consultant Immunologist at Royal Free Hospital LondonQualified diagnostic immunopathologist as well as holding MHRA Qualified Person status for the release of ATMPs for clinical trialsСurrent Vice President (Europe & Middle East) of the International Society for Cell Therapy

Has over 20 years' experience in adoptive immunotherapy of cancer and has focussed on the role of the innate immune responses; especially the role of natural killer (NK) cells. Particularly interested in translational research and established the first academic GMP facility in the UK for the production of human cells as medicines in 2001. This GMP facility now produces somatic cell medicines, gene therapies and tissue engineered products. Professor Lowdell led the technology transfer of his own adoptive NK cell therapy product into three commercial CMOs in the US and was the chief scientific officer for the US clinical trial.

His interest in clinical translation of cell and tissue therapies led to him being responsible for the first GMP-compliant stem cell-derived airway transplant produced as an ATMP in the EU and he now holds >£12m funding to perform formal clinical trials of stem cell derived trachea and larynx as well as the first UK clinical trial of an iPS cell-derived product. His newly refurbished ATMP GMP suite at RFH consists of 10 state-of-the-art manufacturing labs and over 20 staff supporting multiple academic and commercial trials.

Scientific awards and memberships Professor Lowdell has held and holds numerous appointments to academic and government advisory boards in the UK and overseas. Recently he was a member of the UK Government Regenerative Medicine Expert Review Group and is a member of the scientific advisory boards, consultant to or founder of many of the key companies involved in ATMP development in the EU and USA including Autolus Ltd, Achilles Therapeutics Ltd, Cell Medica Ltd, InmuneBio Inc, NWBio Therapeutics.

Münster, Germany

Hans Schöler

Director and Scientific Member at the Max Planck Institute for Molecular Biomedicine

1999-2004 - Full Professor of Reproduction Physiology at the School of Veterinary Medicine and Director of the Center of Animal Transgenesis and Germ Cell Research at the University of Pennsylvania/USA

Since 2004 - Adjunct Professor of Biochemistry, University of Pennsylvania, School of Veterinary Medicine, Department of Animal Biology, Philadelphia/USA

Since 2003 - Director and Scientific Member at the Max Planck Institute for Molecular Biomedicine

Prof. Dr. rer. nat. Dominik Paquet headed a research group in the Institute for Stroke and Dementia Research in the end on 2016. He was appointed Professor for Neurobiology and is a member of the Munich Cluster for Systems Neurology (SyNergy). Following his PhD at the LMU Munich, Prof. Paquet worked as a New York Stem Cell Foundation Druckenmiller Fellow in the laboratory of Marc Tessier-Lavigne, where he pioneered the use of CRISPR/Cas9 gene editing in induced pluripotent stem cells to study diseases of the human brain.

His research at the ISD is focused on the molecular and cellular mechanisms leading to neuronal death and cognitive decline in patients with neuropsychiatric disorders (e.g. Alzheimer's disease and Frontotemporal dementia) and neurovascular impairments (stroke and vascular cognitive impairment). He plans to build advanced human in vitro model systems based on patient-derived cells that recapitulate major disease hallmarks, and thus facilitate molecular studies and accelerate the identification of novel therapeutic approaches.

Research interests • molecular and cellular mechanisms leading to neuronal death and cognitive decline in patients with neuropsychiatric disorders • neurovascular impairments

Since 2013 Jens C. Schwamborn, PhD, is head of the Developmental and Cellular Biology group at the Luxembourg Centre for Systems Biomedicine as well as Professor at the University of Luxembourg. Additionally, since 2016 Jens is Chief Scientific Officer of the biotech company Braingineering Technologies SARL. In 2002 Jens obtained a diploma in Biochemistry from the University Witten/Herdecke in Germany and in 2005 a PhD in Biology from the University Muenster in Germany. He worked as a postdoctoral researcher at the Institute for Molecular Biotechnology in Vienna / Austria.

The focus of his work over the last years was on Neurobiology, Stem Cell research and Parkinson's disease. In particular he is interested in using human induced pluripotent stem cells for the development of advanced approaches for in vitro disease modeling. Jens published more than 50 papers in peer reviewed journals, holds several patents and severs as reviewer for numerous journals and funding agencies.

Research Interests:

Parkinson's disease

Systems Biomedicine

Stem Cells

Neurogenesis

Regeneration

London, UK

Stephen Sullivan

PhD MBA FRSM

Dr Sullivan earned his PhD at the Roslin Institute (Edinburgh) under Professor Ian Wilmut and Dr Jim McWhir, becoming one of the first researchers in Europe to culture human embryonic stem cells. His work focused on pluripotency induction in human somatic cells. Thereafter, Dr Sullivan worked as a Research Fellow at the University of Cambridge, Harvard University, and UCSD deepening his expertise of other human stem cell types (including induced pluripotent stem cells) and their applications for human medicine. While at Harvard, he read 'How Economics Shapes Science' by Paula Stefan, which stimulated his interest in the financial, as well as the scientific and medical, hurdles that must be surmounted to bring stem cell therapies to the clinic.

He also worked for Novartis, dealing with clinical trial management and compliance, to better understand the Industrial perspective on bringing novel therapies to market. Thereafter, he earned an MBA at Trinity College Dublin focusing on risk mitigation within the nascent pluripotent stem cell market. From 2008-2017, Dr Sullivan was the Chief Scientific Officer of the Irish Stem Cell Foundation, where working with others, he facilitated the introduction of stem cell legislation into the Irish Program for Government. He is an honorary associate of the Scottish National Blood Transfusion Service, a member of Human Pluripotent Stem Cell Advisory Committee at University College Cork, and Chief Editor of 'Human Embryonic Stem Cells – The Practical Handbook' published by Wiley & Sons.

In June 2017, Dr Sullivan joined GAiT, a new initiative supporting implementation and clinical application of therapies derived from pluripotent stem cells for the benefit of patients globally. GAiT is supported by an international consortium of organisations including the Cell and Gene Therapy Catapult (London, UK), the Centre for Commercialisation of Regenerative Medicine (Toronto, Canada), the Korea HLA-Typed iPSC Banking Initiative (Seoul, Korea) and the New York Stem Cell Foundation (New York, USA).

Scientific awards and memberships

Honorary associate of the Scottish National Blood Transfusion Service

Member of Human Pluripotent Stem Cell Advisory Committee at University College Cork

Chief Editor of "Human Embryonic Stem Cells – The Practical Handbook"

Global Alliance for iPSC Therapies member

St. Petersburg, Russia

Alexey Tomilin

Ph.D. Sci.D. Corresponding Member of the Russian Academy of SciencesHead of Laboratory of the Molecular Biology of Stem Cells, Institute of Cytology RAS

Dr. Alexey Tomilin has broad interests in cell and molecular biology with a primary focus on pluripotent stem cells, such as embryonic stem (ES) and induced pluripotent stem (iPS) cells. Studying molecular mechanisms of stem cell maintenance and development is his primary focus, however, he also develops applications of pluripotent stem cells in clinics.

2017 Honorary Diploma of the Russian Academy of Sciences "For conscientious work, great contribution to the development of fundamental and applied science, in connection with the 60th anniversary of the foundation of the Institute of Cytology"

2017 Member of program committee of the III National Congress of Regenerative Medicine, November 15-18, 2018, Moscow, Russia.

Dr. Sci.(Biol.) Vavilov Institute of General Genetics, Laboratory of Stem Cell BiologyHead of the Laboratory of Cell Biology at the Research Center of Physical-Chemical Medicine in Moscow.

Graduated from the Lomonosov Moscow State University. She defended her PhD thesis "New approaches to study the loop organization of chromosomes" in 1995. For many years Maria Lagarkova works in the field of stem cell biology. She is a head of the Laboratory of Cell Biology at the Research Center of Physical-Chemical Medicine in Moscow. The basic directions of Maria Andreevna's scientific research are the study of the mechanisms of differentiation and epigenetics of pluripotent stem cells and the modeling of neurodegenerative diseases with induced pluripotent stem cells.

Research interests

mechanisms of differentiation and epigenetics of pluripotent stem cells

neurodegenerative diseases with induced pluripotent stem cells

St. Petersburg, Russia

Anna Malashicheva

PhD Head of laboratory of Molecular Cardiology, Federal Almazov Medical Research Centre Associate Professor, Dept. of Embryology, Biological Faculty, St.-Petersburg State University

Research interests

developmental biology

cellular and molecular biology of stem cells

translational medicine

Ongoing projects in the laboratory

Lineage specific function of Notch signaling in the cardiovascular system, role of Notch signaling in aortic diseases and congenital heart diseases

Graduated from Moscow Institute of Physics and Technologics (MIPT), Department of Molecular Biology and Physics. Defended thesis on the creation of immortalized cultures of human stem and progenitor cells by telomerase activation. At this moment works at the Koltsov Institute of Developmental Biology in the laboratory of cell biology.

Research interests

stem cells

regenerative medicine

genome editing

Villejuif, France

Yegor Vassetzky

PhD, Researcher CNRS research directorHead of the laboratory of Nuclear Organization and Pathologies at the Institut Gustave Roussy Head of a Joint French-Russian Oncology Research LaboratoryDirector, Joint French-Russian Cancer Research Laboratory

Graduated from the Moscow State University in 1984. After a PhD thesis in 1989, he worked as a postdoctoral fellow in Paris, Lausanne and Montpellier. Since 2002 he heads the Nuclear Organization and Pathologies laboratory at the Gustave Roussy Institute (Villejuif, France). His main research interests concern epigenetic regulation and nuclear organization in genetic diseases and cancers. He has more than 130 publications in peer-reviewed journals.

Education:

1985 - B.Sc., Department of Molecular Biology, State University of Moscow. Field: Biochemistry

2011-present Member of the Board of Directors, Affitech SA (NASDAQ OMX: AFFI)

2012-2015 Chairman of the International Scientific Advisory Board, Institute of Molecular Biology and Genetics, Kiev, Ukraine

2013-2016 Chairman of the Biology section, Dynasty charity fund

2015-present Member of the International Committee, Wilhelm Bernhard Workshop

Research interests

Epigenetic regulation and nuclear organization in genetic diseases and cancers

Cardiff, UK

Philip Stephens

Professor of Cell Biology and Dean of International for the College of Biomedical and Life Sciences at Cardiff University HTA Designated Individual Cardiff University Biobank academic lead President of the European Tissue Repair Society

College of Biomedical & Life Sciences, Cardiff University

Professor Phil Stephens is currently Professor of Cell Biology and Dean of International for the College of Biomedical and Life Sciences at Cardiff University. He moved to Cardiff University in 1994 as Post Doctoral Researcher having obtained a first class honours degree and a PhD from Leeds University. Subsequently he established the Wound Biology Group with a clinical colleague. He was previously Vice Dean (Research) at the School of Dentistry, Cardiff University and Chair of the Cardiff Institute of Tissue Engineering and Repair.

His research interests are in the fields of oral progenitor cells, differential wound healing, ageing, tissue engineering, animal replacement model systems and cellular imaging. Within these areas he has managed research projects (Research Council, Charity and Industry) totalling over £4.5 Million, published widely, obtained patents and his group has won many National and International prizes.

Externally he works closely with organisations such as the National Centre for the Replacement, Refinement and Reduction of Animals in Research and reviews grant applications and manuscripts for numerous national and international funders/journals. He is currently setting up an overarching tissue biobank at Cardiff University to support research in both academic and industrial settings.

Research interests

oral progenitor cells

differential wound healing

ageing

tissue engineering

animal replacement model systems

cellular imaging

Moscow, Russia

Alexander Fedulov

Moscow Regional Research Clinical Institute

In 2013 won of the "UMNIK" program with topic: "A new technique of treating infertility and restore of male testosterone generative function." Since 2015 - a scientific employee in the Department of Pediatric Surgery in the "Moscow Regional Research Clinical Institute". Member of the group of regenerative medicine in the "Moscow Regional Research Clinical Institute".

At the moment, the scientific work is devoted to research of the effect of vitalized and non-vitalized biodegradable implants of various compositions on regeneration of the gastrointestinal tract, when it is damaged, in experiment.

Research interests

regenerative medicine

cellular technologies

biodegradable implants

reconstructive operations on gastrointestinal tract

Moscow, Russia

Konstantin Yarygin

PhD, MDHead of the Cell Biology Lab at IBMC, Moscow, Russia Professor at the Department of Pathophysiology at the Russian Medical Academy of Postgraduate Education

Leading research scientist in the Department of Biochemistry and Molecular Medicine, Faculty of Medicine, M.V. Lomonosov Moscow State University

Graduated summa cum laude from Faculty of Biology, M.V. Lomonosov Moscow State University in 1997. In 2001, she got her PhD from Cardiology Research Center, Moscow, Russia. Currently she is a leading research scientist in the Department of Biochemistry and Molecular Medicine, Faculty of Medicine, M.V. Lomonosov Moscow State University.

Studies of Dr. Kalinina are focused on cellular and molecular mechanisms of tissue regeneration; stem and progenitor cell physiology. In this field she has published over 50 articles, co-author of 19 RF patents.

She was awarded by Rector stipend to young teachers and scientist achieved a significant success in teaching and research (2005 and 2007).

Research interests

cellular and molecular mechanisms of tissue regeneration

stem and progenitor cell physiology

Moscow, Russia

Ekaterina Vorotelyak

PhDHead of the Cellular Biology laboratory at N.K. Koltzov Institute of Developmental Biology RASAssociate Professor at Moscow State UniversityHead of the Department of Regenerative Medicine in Pirogov Russian National Research Medical UniversityCorresponding member of Russian Academy of Sciences

In 1993 Vorotelyak obtained a diploma in Cell Biology and Histology from Moscow State University and in 1998 a PhD in Biology. She worked as postdoctoral fellow in N.K. Koltzov Institute of Developmental Biology of Russian Academy of Sciences in Moscow. In 2016, she was elected as a Corresponding member of Russian Academy of Sciences.

In recent years she focused on epidermal and hair follicle morphogenesis, mesenchymal and epidermal stem cells in the skin and development of new technologies for regenerative medicine. Vorotelyak published more than 60 papers in peer reviewed journals, holds several patents and severs as reviewer for numerous funding agencies.

2001-2007 Head of the laboratory and professor in the same Department (Dermatology, Columbia University, New YorkSignal transduction pathways in normal skin and skin neoplastic/cornification disorders; skin regeneration; the role of environmental stress in skin pathology with major focus on environmentally-regulated dioxin receptor (AhR) and hypoxia-induced factor (HIF) pathways.

2008-2012 Principal Investigator, Head of the laboratory, Scientific Lead in Skin Cancer Group, Division of Medical Sciences, University of Dundee, Dundee, UK.Role of environmental factors (hypoxia, UV light and AhR-activating xenobiotics) in control of HIF/AhR/ARNT machinery in the skin; interactions between AhR and HIF pathways and their role in skin aging, skin stem cell activity, regeneration and in pathogenesis of environmentally-modulated skin disorders (cancer, psoriasis, barrier function, desquamation, hair loss); interactions between AhR/HIF and retinoid-induced pathways.

2013-current Head of the laboratory of Tissue engineering, Kurchatov complex of NBICS technologies, Kurchatov institute, Moscow, RussiaMechanisms of organogenesis and regeneration in mammals, tissue engineering.

MD, PhD Professor of Cellular Neurobiology Director Institute of Cell Biology and Neurobiology, Charité – Universitätsmedizin Berlin Leading Scientist and Director of Biomedical Cluster, Lobachevsky State University of Nizhny Novgorod

Magdeburg, Germany

Inna Lavrik

Head of Translational Inflammation Research, Medical Faculty, Otto von Guericke University, MagdeburgHead of laboratory of systems biology of cell death, Novosibirsk Institute of Cytology and Genetics Leading scientist, Faculty of Fundamental Medicine, Moscow State University

The major scientific focus of Prof. Lavrik is on the molecular mechanisms governing the function of macromolecular complexes in death receptor networks, their posttranslational modifications and computational modeling of apoptosis pathways. She has made major contributions to the understanding of the molecular mechanisms of activation of the CD95 death-inducing signalng complex (DISC) as well as performed a number of pionerring studies in the field of systems biology of apoptosis.

Professor Inna Lavrik has been working in the cell death research since 2000. She did postdoctoral research at the Division of Immunogenetics led by Prof. Peter H Krammer at DKFZ (German Cancer Research Center) in Heidelberg. She became a group leader at the same deparment in 2005. Since 2007 she has been running her group on Systems Biology studies of apoptosis at Bioquant/Heidelberg. She accomplished her habilitation in 2010 in Heidelberg. In 2012 she was appointed Professor at the Medical Faculty of the Otto von Guericke University of Magdeburg. Currently she is head of Translational Inflammation Research located at the Institute of Systems Biology at the Otto von Guericke University of Magdeburg.

Professor Lavrik is a member of the editorial board of the Nature group Journal Cell Death and Discovery, Frontiers in Cell death and the Russian Journal of Genetics.

;;Jens SchwamborneUniversité du Luxembourg;Advanced modelling of neurodegeneration with three-dimensional human midbrain organoids
;;Ekaterina VorotelyakKoltzov Institute of Developmental Biology RAS;Skin tissue and organ regeneration
;;Phil StephensCollege of Biomedical & Life Sciences, Cardiff University;Fibroblasts: chronically bad but not so down in the mouth
;;Dmitry PapatsenkoSkolkovo Institute of Science and Technology;Gene expression in single cells: how much new we can learn from the data
;;Andrey PanteleevNational Research Center “Kurchatov Institute”;Bioengineering a functional tracheal epithelium: matrices and cells
;;Alexander FedulovMoscow Regional Research and Clinical Institute;Photocurable biodegradable implants based on methacrylated silk fibroin for the prevention and treatment of insolvency of the gastrointestinal tract anastomosis

;Round table;Representatives from the Russian Ministry of health and the leading cell technology centers from Russia and EU;The main goal of all cell technology research activities is to translate the results of basic science into therapeutics that helps patients. This round table allows the conference participants to get a deeper understanding of the existing standards and regulations in Russia and European Union related to cell therapy translation into practice.Speakers will share their experience and discuss actual challenges in biomedical cell products practical application, registration and founding cell banks.

It is possible to conclude an agreement for participation in the conference.

To pay by a legal entity, please send us the details of payer organization and application with the list of participants.

Venue

CTERP Conference takes place in Novotel Moscow City. It's a part of The Moscow International Business Centre and located on the Presnenskaya embankment of the Moscow River, approximately 4 kilometers west of Red Square, and just east of the Third Ring Road.