Painkiller Already (PKA) is a weekly online podcast produced by Woody (WoodysGamertag), Kyle (FPSKyle) and Taylor (MurkaDurkah). Episodes usually range from three to four hours long, often include an additional guest and feature a varied selection topics. For more information please visit the PKA Wiki.

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I would recommend having a clear goal in mind when you start. Like, if you want your character to be beastly at melee early on, be sure to make your S.P.E.C.I.A.L. reflect that. For example, my first character was supposed to be someone who would speak loudly and carry a big stick, so I chose higher charisma and strength in a trade-off for lower intelligence and endurance. Most of all, have fun, it's a great game!

A melee character with low endurance is a mistake. Endurance increases or decreaes HP and since your primarily melee, you're going to be a bullet magnet for sure.

EDIT: Oh yeah, and also high charisma doesn't really matter for speech. Use the extra SPECIAL points for something useful for melee, like Luck, or Strength. Speech slightly decreases it a few points depending on luck aswell as charisma. But you still can easily attain 100 speech and barter with 1 charisma.

Explore don't follow the main story only. Also get you luck high in the beginning so when you get to the strip you can dominate black jack and earn a load of caps. Get the swift learner perk when you level up so you can level up faster, and also don't try and run straight to the strip from the start because it's almost entirely surrounded by high level enemies. Other than that buckle up for an epic ride.

Dont save randomly. You might end up trying to figure out what the buttons do and accidently shooting a friendly after you spent a long time making your character and then save just as the town is about to turn on you and you have to restart to make things normal again. :(

The mods for the PC version are insane. From Graphical overhauls, to new gameplay mechanics along with custom made quests from people. Some custom content quests have been voice acted too, so it's like free DLC. :)