as long as you have sandbox configured right ... you can actually live without any real-time AV ... so I suggest if you really want MSE add sandboxie and reinstall MBAM for on demand scanning and your good to go.

I don't know about the rest of your setup. But let's say you use Vista/Win 7, with UAC enabled and Windows Firewall (Win 7 Firewall is very good, Vista is also good) enabled and now Microsoft Security Essentials as realtime antimalware.
As long as you are an experienced user, you know what kind of websites/links/ads you should ignore and so on you will be absolutely fine with MSE, a good and simple to use program.

Although a second-opinion is always usefull, candidates: Hitman Pro, a-squared Free and Malwarebytes' Anti-Malware.
If you are visiting risky websites and stuff I would suggest adding something like Sandboxie.

as long as you have sandbox configured right ... you can actually live without any real-time AV ... so I suggest if you really want MSE add sandboxie and reinstall MBAM for on demand scanning and your good to go.

Yes I really like MSE but I also have Malwarebytes Anti-Malware running real time. Runs great together here with Win XP Pro SP3. Been using MSE since the beta last year. I did have problems with MSE only updating once per day. But solved that problem by changing the "SignatureUpdateInterval" in regedit from 24 to 1 hour (will check for updates every hour now). I also always use Sandboxie Paid version with firefox and IE forced.

As a minimum, a delayed quick scan(available in latest build) with HitMan Pro would be advisable. May be its just me but MSE as the only solution doesn't inspire confidence.

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It doesn't for me either. It did to some degree before, but even trjam has now switched it for Prevx, which is not a isolation security program either. I'm sure he'll switch soon again and praise it to heaven just like he always does.

It doesn't for me either. It did to some degree before, but even trjam has now switched it for Prevx, which is not a isolation security program either. I'm sure he'll switch soon again and praise it to heaven just like he always does.

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I respect trjam. He defies all comments on him by his sheer nimbleness.

as long as you have sandbox configured right ... you can actually live without any real-time AV ... so I suggest if you really want MSE add sandboxie and reinstall MBAM for on demand scanning and your good to go.

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Are you saying that Sandboxie installed is not safe to browse any website unless it's configured somehow?

It doesn't for me either. It did to some degree before, but even trjam has now switched it for Prevx, which is not a isolation security program either. I'm sure he'll switch soon again and praise it to heaven just like he always does.

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Prevx is good. But Eset is my baby even though 4.2 is killing me in speed. I am waiting though on my favorite to hopefully arrive one day, Geswall 3.0 64 bit ready.

Are you saying that Sandboxie installed is not safe to browse any website unless it's configured somehow?

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There are 2 important one's that are not set by default on a win32 OS. Delete sandbox on exit to clear any junk from your browsing session and Drop rights. I also add a colored border around the sandboxed app. However, SBIE is still safe without these set.