We offer CBD Hemp related products providing the best potencies and purity of Cannabidiol (CBD) products available nationwide. Our mission is to educate and promote natural therapies as part of our approach to optimum health and wellness. We have various products to suit the multiple needs and conditions of our clients.

===>Delivery of the product to all states of America<===

"Cannabidiol: Barriers to Research and Potential Medical Benefits"

Mr. Chairman, Ms. Chairwoman, and Members of the Senate Drug Caucus, thank you for inviting the National Institute on Drug Abuse (NIDA), a component of the National Institutes of Health (NIH), to participate in this hearing to share what we know about the biology and the potential therapeutic effects of cannabidiol (CBD), one of the main active chemical compounds found in marijuana. In light of the rapidly evolving interest in the potential use of marijuana and its derivative compounds for medical purposes, it is important to take stock of what we know and do not know about the therapeutic potential of CBD.

Background

To date, 23 states and the District of Columbia have passed laws allowing marijuana to be used for a variety of medical conditions. Fifteen additional states have enacted laws intended to allow access to CBD oil and/or high-CBD strains of marijuana. Interest in the potential therapeutic effects of CBD has been growing rapidly, partially in response to media attention surrounding the use of CBD oil in young children with intractable seizure disorders including Dravet syndrome and Lennox-Gastaut syndrome. While there are promising preliminary data, the scientific literature is currently insufficient to either prove or disprove the efficacy and safety of CBD in patients with epilepsy.i and further clinical evaluation is warranted. In addition to epilepsy, the therapeutic potential of CBD is currently being explored for a number of indications including anxiety disorders, substance use disorders, schizophrenia, cancer, pain, inflammatory diseases and others. My testimony will provide an overview of what the science tells us about the therapeutic potential of CBD and of the ongoing research supported by NIH in this area.
CBD Biology and Therapeutic Rationale

Neuroprotective and Anti-Inflammatory Effects

CBD has also been shown to have neuroprotective properties in cell cultures as well as in animal models of several neurodegenerative diseases, including Alzheimer’s,xii,xiii,xiv stroke,xv glutamate toxicity,xvi multiple sclerosis (MS),xvii Parkinson’s disease,xviii and neurodegeneration caused by alcohol abuse.xix Nabiximols (trade name Sativex), which contains THC and CBD in roughly equal proportions, has been approved throughout most of Europe and in a number of other countries for the treatment of spasticity associated with MS. It has not been approved in the United States, but clinical trials are ongoing, and two recent studies reported that nabiximols reduced the severity of spasticity in MS patients.xx,xxi There have been limited clinical trials to assess the potential efficacy of CBD for the other indications highlighted; however, a recent small double-blind trial in patients with Parkinson’s disease found the CBD improved quality-of-life scores.xxii

Analgesic Effects

There have been multiple clinical trials demonstrating the efficacy of nabiximols on central and peripheral neuropathic pain, rheumatoid arthritis, and cancer pain.xxiii In addition, nabiximols is currently approved in Canada for the treatment of central neuropathic pain in MS and cancer pain unresponsive to opioid therapy. However, the current evidence suggests that the analgesia is mediated by THC and it is unclear whether CBD contributes to the therapeutic effects.xxiv THC alone has been shown to reduce pain;xxv,xxvi we are unaware of clinical studies that have explored the efficacy of CBD alone on pain. However, the anti-inflammatory properties of CBD (discussed above) could be predicted to play a role in the analgesic effects of nabiximols. Recent research has also suggested that cannabinoids and opioids have different mechanisms for reducing pain and that their effects may be additive, which suggests that combination therapies may be developed that may have reduced risks compared to current opioid therapies. However, this work is very preliminary.xxvii

Anti-Tumor Effects

In addition to the research on the use of cannabinoids in palliative treatments for cancer—reducing pain and nausea and in increasing appetite—there are also several pre-clinical reports showing anti-tumor effects of CBD in cell culture and in animal models.xxviii These studies have found reduced cell viability, increased cancer cell death, decreased tumor growth, and inhibition of metastasis (reviewed in McAllister et al, 2015).xxix These effects may be due to the antioxidant and anti-inflammatory effects of CBD;xxx however these findings have not yet been explored in human patients. There are multiple industry sponsored clinical trials underway to begin to test the efficacy of CBD in human cancer patients.

Anti-Psychotic Effects

Marijuana can produce acute psychotic episodes at high doses, and several studies have linked marijuana use to increased risk for chronic psychosis in individuals with specific genetic risk factors. Research suggests that these effects are mediated by THC, and it has been suggested that CBD may mitigate these effects.xxxi There have been a few small-scale clinical trials in which patients with psychotic symptoms were treated with CBD, including case reports of patients with schizophrenia that reported conflicting results; a small case study in patients with Parkinson’s disease with psychosis, which reported positive results; and one small randomized clinical trial reporting clinical improvement in patients with schizophrenia treated with CBD.xxxii Large randomized clinical trials would be needed to fully evaluate the therapeutic potential of CBD for patients with schizophrenia and other forms of psychosis.

CBD has shown therapeutic efficacy in a range of animal models of anxiety and stress, reducing both behavioral and physiological (e.g., heart rate) measures of stress and anxiety.xxxiii,xxxiv In addition, CBD has shown efficacy in small human laboratory and clinical trials. CBD reduced anxiety in patients with social anxiety subjected to a stressful public speaking task.xxxv In a laboratory protocol designed to model post-traumatic stress disorders, CBD improved “consolidation of extinction learning”, in other words, forgetting of traumatic memories.xxxvi The anxiety-reducing effects of CBD appear to be mediated by alterations in serotonin receptor 1a signaling, although the precise mechanism remains to be elucidated and more research is needed.xxxvii

Efficacy for Treating Substance Use Disorders

Early preclinical findings also suggest that CBD may have therapeutic value as a treatment of substance use disorders. CBD reduced the rewarding effects of morphinexxxviii and reduced cue-induced heroin seekingxxxix in animal models. A few small clinical trials have examined CBD and/or nabiximols (THC/CBD) for the treatment of substance use disorders; however, the available data are not sufficient to draw conclusions. NIDA is supporting multiple ongoing clinical trials in this area.

Safety of CBD

For reasons discussed previously, despite its molecular similarity to THC, CBD only interacts with cannabinoid receptors weakly at very high doses (100 times that of THC),xl and the alterations in thinking and perception caused by THC are not observed with CBD.iii.iv,v The different pharmacological properties of CBD give it a different safety profile from THC.

Research Opportunities and Challenges

This is a critical area for new research. While there is preliminary evidence that CBD may have therapeutic value for a number of conditions, we need to be careful to not get ahead of the evidence. Ninety-five percent of drugs that move from promising preclinical findings to clinical research do not make it to market. The recently announced elimination of the PHS review of non-federally funded research protocols involving marijuana is an important first step to enhance conducting research on marijuana and its components such as CBD. Still, it is important to try to understand the reasons for the lack of well-controlled clinical trials of CBD including: the regulatory requirements associated with doing research with Schedule I substances, including a requirement to demonstrate institutional review board approval; and the lack of CBD that has been produced under the guidance of Current Good Manufacturing Processes (cGMP) – required for testing in human clinical trials – available for researchers. Furthermore, the opportunity to gather important information on clinical outcomes through practical (non-randomized) trials for patients using CBD products available in state marijuana dispensaries is complicated by the variable quality and purity of CBD from these sources.

Ongoing CBD Research

The NIH recognizes the need for additional research on the therapeutic effects of CBD and other cannabinoids, and supports ongoing efforts to reduce barriers to research in this area. NIH is currently supporting a number of studies on the therapeutic effects as well as the health risks of cannabinoids. These include studies of the therapeutic value of CBD for:

Treatment of substance use disorders (opioids, alcohol, cannabis, methamphetamine)
Attenuation of the cognitive deficits caused by THC
Neuropathic pain due to spinal cord injury
Mitigating the impact of cannabis use on risk for schizophrenia
Examination of the potential of CBD as an antiepileptic treatment

It is important to note that NIDA’s mission is focused on drug abuse; studies related to the therapeutic effects of CBD in other areas would be funded by the Institute or Center responsible for that program area. For example, studies related to epilepsy will likely be funded by the National Institute of Neurological Disorders and Stroke or by the Eunice Kennedy Shriver National Institute of Child Health and Human Development, while studies related to schizophrenia will likely be funded by the National Institute on Mental Health.
Conclusion

There is significant preliminary research supporting the potential therapeutic value of CBD, and while it is not yet sufficient to support drug approval, it highlights the need for rigorous clinical research in this area. There are barriers that should be addressed to facilitate more research in this area. We appreciate the opportunity to testify on the potential use of CBD for therapeutic purposes. Thank you again for inviting me here today, and I look forward to any questions you may have.

Copyright 2017 Natural Alchemist. All Rights Reserved.

* These statements have not been evaluated by the FDA. If you are pregnant, nursing, taking medications, or have a medical condition, consult your physician before using this product. Representations regarding the efficacy and safety of CBD have not been evaluated by the Food and Drug Administration. The FDA only evaluates foods and drugs, not supplements like these products. These products are not intended to diagnose, prevent, treat, or cure any disease. Click here to find evidence of a test, analysis, research, or study describing the benefits, performance or efficacy of CBD based on the expertise of relevant professionals.

Best offer click here

TAGS:
high cbd hemp oil Americarainehow to get rid of weeds in your grass is greener # cbd oil for sale North Liberty Indianacbd oil to buy Gouverneur New York @ buy cannabis seeds canada legalizationcbd oil for sale Hamilton Illinois @ where can you buy cannabis oil in coloradocheap cbd dabs terpenes compounds # hemp seed oil buy online St. Pierre Montana
buy cannabis online europe map
where to buy cbd oil near 92661 weather nyc hourly
cbd oil for cancer patients in colorado
how to buy weeds online season 8
buy cbd oil online reddit swagbucks paypal incentive
hi yield 529 msma weed killer directionsmsma weed killer lowesnatural weed killer recipe for lawns
cbd benefits flyers pizza galloway
homemade bleach weed killer recipe
buy cannabis online discreetly or discretely dictionary
buy hemp oil for cancer America org sync
buy weed online America dictionary language of origin
medical marijuana colorado cbd crystals how to use
buy cannabis online discreetly greek redbubble t-shirts
how to get weed out of your system in 10 days
cbd cancer cure testimonials examples
buy cbd oil ireland 2016 eurovision results
effects of cbd oil on schizophrenia dosage calculation
natural weed killer recipe 30 percent vinegar diet
buy weed eaters nzs
cbd cancer research institute
how to get rid of dollar weeds naturally
how much weed to buy for 5$ itunes codes no survey
Producers of pure products were forced out of the market, mutually exclusive, mutants. Cannabis while no one has modified, it is created by nature brilliantly. This plant is very resistant to unfavorable factors and insects. The only "enemy" of the man growing hemp grain is the feathered one, but the seeds are so carefully hidden in the inflorescences that most of them still remain untouched.
Most minds reject even attempting to calculate the expansive numbers of building athletes on an annual basis... and with good reason. Football is still America's most active pastime in Statesville North-Carolina - with over 1,088,000 participants in the sport from pee wee to professional. But outdoor track and field, basketball, soccer, baseball, volleyball, cross-country, tennis, and swimming are close on its heels. Many sports run almost neck-in-neck in gender participation while volleyball, tennis, and swimming are dominated by females. Still, regardless of how much training a player has, a simple accident can lead to a lifetime of pain, suffering, and even early permanent retirement from the activity. But that doesn't necessarily have to happen. In fact, science has recently discovered a link between athletic healing and CBD (Cannabidiol). But can cannabis really be the key to protecting and healing over seven million American athletes? First of All, What is CBD? The use of medical marijuana is a relatively new debate, especially considering cannabis is one of the oldest medicinal herbs known. In fact, religions and science alike can trace its use back to ancient times for both recreational and medicinal use. Yet, for over a century, scientists have focused solely on the negative aspects of the plant. The shift in Western society is so new that it's taken media stage and confused a slew of people in the process. But the truth is, cannabis has always been beneficial for medicinal needs. Science just needed to narrow those findings down to meet political expectations.

CBD American Shaman is a Kansas City-based supplier that ships CBD products nationwide.
10. Our exclusive supplier, Folium Biosciences, is the largest fully vertically integrated grower, manufacturer, supplier of CBD in the USA.?

But the U.S. Drug Enforcement Administration classifies all parts of the cannabis plant as a Schedule I controlled substance — subject to the agency’s strictest regulation.
Smith said he thinks he’s come to an understanding with local law enforcement. But he’s not sure where he stands with the state, and he has some concerns about the strong anti-marijuana stance of new U.S. Attorney General Jeff Sessions.
2. This means our first extraction produces an oil of 70% CBD - the highest natural amount of CBD of any supplier in the world.?

The highest quality fiber (long, strong) is formed in hemp stems when grown under conditions of sufficient moistening and supply of nutrients throughout the growing season, especially during the period of intense formation of fibrous bundles with long fibers that is observed from the onset of budding to the flowering of plants. With insufficient soil moisture at this time, fiber formation processes slow down, fibrous bunches are formed loose, with poor fiber quality. It should, however, be borne in mind that excessive soil moisture, especially often observed when growing hemp on soils with a close groundwater table, adversely affects their growth and development. The most favorable water regime for cannabis is made with soil moisture during the vegetation in the range of 70 - 80% HB.
The answer was not so simple.