Preparation and Storage

Stability and Storage

This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

Alternative names

11S regulator complex gamma subunit

11S regulator complex subunit gamma

Activator of multicatalytic protease subunit 3

Ki

Ki antigen

Ki nuclear autoantigen

Ki, PA28 gamma

PA28 gamma

PA28g

PA28gamma

Proteasome (prosome, macropain) activator subunit 3

Proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)

Proteasome activator 28 gamma

Proteasome activator 28 subunit gamma

Proteasome activator complex subunit 3

Proteasome activator subunit 3

PSME3

PSME3_HUMAN

REG GAMMA

REG-gamma

see all

Function

Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a donut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regulation.

Images

Functional Studies - Recombinant human PSME3 protein (ab206156)

Activation of 5 nM 20S proteasome by 25 nM ab206156, the proteasome activity was assayed by using 50 µM Suc-LLVY-AMC as the substrate. The AMC fluorescence was monitored by a plate reader with excitation and emission filters of 360±40 nm and 460±30 nm, respectively.