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.
The
molecular-force sensor titin kinase …
… (TK) is embedded in the M-band structure of the sarcomere at an ideal position to
sense force imbalances. H. E. Gaub and E. M. Puchner demonstrate in their Communication on page 1147 ff. a new AFM-based single-molecule pump-and-probe protocol
to mechanically prepare different conformations of TK and to read out their function.
The results show that the binding pocket for the co-substrate ATP is shielded by two
sequential barriers in the force-induced activation pathway.
Inside Cover
Elias M. Puchner and Hermann E. Gaub*
The molecular-force sensor titin kinase (TK) is embedded in the M-band structure of
the sarcomere at an ideal position to sense force imbalances. H. E. Gaub and E. M.
Puchner demonstrate in their Communication on page 1147 ff. a new AFM-based
single-molecule pump-and-probe protocol to mechanically prepare different
conformations of TK and to read out their function. The results show that the binding
pocket for the co-substrate ATP is shielded by two sequential barriers in the forceinduced activation pathway.