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About NUI Galway

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Medicine

Dr. Mary Murphy BSc, Ph.D

Contact Details

Title

Lecturer Above The Bar

Address

Dept. of Medicine & RemediOrbsen BuildingNui, Galway

Telephone:

Ext. 5206

Email:

ei.yawlagiun@yhprum.yram

Biography:

Research interests focus on the biology, mechanism of action and the use of adult stem cells for tissue regeneration in orthopaedic applications. Current research efforts address the clonal heterogeneity of mesenchymal stem cells and the role of epigenetic mechanisms such as DNA methylation in control of differentiation of these cells. Of particular interest is differentiation to the chondrogenic lineage and identification of novel mechanisms or molecules that may be associated with early osteoarthritis as cells in injured or diseased cartilage develop a fibrogenic phenotype. Therapeutic efforts also focus on osteoarthritis with research focused on 1) interrogating the mechanism whereby mesenchymal stem cells modulate progression of osteoarthritis and developing tissue engineering strategies to target the cells to early osteoarthritic cartilage as well as repair of focal cartilage defects.

Research Interests

Research interests focus on the biology, mechanism of action and the use of adult stem cells for tissue regeneration in orthopaedic applications. Current research efforts address the clonal heterogeneity of mesenchymal stem cells and the role of epigenetic mechanisms such as DNA methylation in control of differentiation of these cells. Of particular interest is differentiation to the chondrogenic lineage and identification of novel mechanisms or molecules that may be associated with early osteoarthritis as cells in injured or diseased cartilage develop a fibrogenic phenotype. Therapeutic efforts also focus on osteoarthritis with research focused on 1) interrogating the mechanism whereby mesenchymal stem cells modulate progression of osteoarthritis and developing tissue engineering strategies to target the cells to early osteoarthritic cartilage as well as repair of focal cartilage defects.