3. Hazards Identification

Emergency Overview--------------------------
POISON! DANGER! CORROSIVE. MAY BE FATAL IF SWALLOWED. HARMFUL IF
INHALED OR ABSORBED THROUGH SKIN. CAUSES BURNS TO ANY AREA OF CONTACT. VAPOR
HARMFUL. FLAMMABLE LIQUID AND VAPOR. MAY CAUSE BLINDNESS. CANNOT BE MADE
NONPOISONOUS.

Exposure may result in intense burning of the eyes, nose, throat,
lungs and skin. Experimental studies have indicated that TMAH is a weak
inhibitor of acetylcholinesterase and acts as a cholinergic (muscarinic and
nicotinic) agonist. Depending on the level and duration of exposure, signs and
symptoms may include blurred or double vision; pinpoint pupils; changes in
heart rate and blood pressure; abdominal cramping, nausea and vomiting;
diarrhea, excessive salivation sweating or bronchial secretions; urinary
incontinence; muscle twitching, tremors or convulsions. Other symptoms
consistent with cholinergic activity may also be observed.

Inhalation:Extremely destructive to tissues of the mucous
membranes and upper respiratory tract. May produce upper airway edema,
respiratory failure, pulmonary edema and pnemonitis. Symptoms may include
burning, wheezing, laryngitis, shortness of breath. Toxic effects from the
Methanol component are exerted upon nervous system, particularly the optic
nerve. Once absorbed into the body, it is very slowly eliminated. Symptoms of
overexposure may include headache, drowsiness, nausea, vomiting, blurred
vision, blindness, coma, and death. A person may get better but then worse
again up to 30 hours later. Ingestion:Corrosive. Swallowing
can cause severe burns of the mouth, throat, and stomach. Can cause sore
throat, vomiting and diarrhea. Methanol component is Toxic. Symptoms parallel
inhalation. Can intoxicate and cause blindness. Usual fatal dose: 100-125
milliliters. Skin Contact:Corrosive. Symptoms of redness,
pain, and severe burn can occur. Methanol component is a defatting agent and
may cause skin to become dry and cracked. Skin absorption can occur; symptoms
may parallel inhalation exposure. Eye Contact:Corrosive.
Contact can cause blurred vision, redness, pain and severe tissue burns.
Chronic Exposure:Marked impairment of vision has been
reported. Repeated or prolonged exposure may cause skin irritation.
Aggravation of Pre-existing Conditions:Persons with
pre-existing skin disorders or eye problems or impaired liver or kidney
function may be more susceptible to the effects of the substance.

4. First Aid Measures

Inhalation:Remove to fresh air. If not breathing, give
artificial respiration. If breathing is difficult, give oxygen. Get medical
attention immediately. Ingestion:If swallowed, DO NOT INDUCE
VOMITING. Give large quantities of water. Never give anything by mouth to an
unconscious person. Get medical attention immediately. Skin
Contact:Immediately flush skin with plenty of water for at least 15
minutes while removing contaminated clothing and shoes. Get medical attention
immediately. Wash clothing before reuse. Thoroughly clean shoes before reuse.
Eye Contact:Immediately flush eyes with plenty of water for at
least 15 minutes, lifting lower and upper eyelids occasionally. Get medical
attention immediately.

5. Fire Fighting Measures

Fire:Flash point: 12C (54F) CCAutoignition
temperature: 470C (878F)Flammable limits in air % by volume: lel: 6.7;
uel: 36Flammable Liquid and Vapor! Explosion:Above the
flash point, explosive vapor-air mixtures may be formed. Sealed containers may
rupture when heated. Contact with strong oxidizers may cause fire. Sensitive
to static discharge. Fire Extinguishing Media:Water spray, dry
chemical, alcohol foam, or carbon dioxide. Water may be ineffective.
Special Information:In the event of a fire, wear full
protective clothing and NIOSH-approved self-contained breathing apparatus with
full facepiece operated in the pressure demand or other positive pressure
mode. Use water spray to blanket fire, cool fire exposed containers, and to
flush non-ignited spills or vapors away from fire. Vapors can flow along
surfaces to distant ignition source and flash back.

6. Accidental Release Measures

Ventilate area of leak or spill. Remove all sources of ignition.
Wear appropriate personal protective equipment as specified in Section 8.
Isolate hazard area. Keep unnecessary and unprotected personnel from entering.
Contain and recover liquid when possible. Use non-sparking tools and
equipment. Collect liquid in an appropriate container or absorb with an inert
material (e. g., vermiculite, dry sand, earth), and place in a chemical waste
container. Do not use combustible materials, such as saw dust. Do not flush to
sewer! If a leak or spill has not ignited, use water spray to disperse the
vapors, to protect personnel attempting to stop leak, and to flush spills away
from exposures.

J. T. Baker SOLUSORB(R) solvent adsorbent is
recommended for spills of this product.

7. Handling and Storage

Protect against physical damage. Store in a cool, dry
well-ventilated location, away from any area where the fire hazard may be
acute. Outside or detached storage is preferred. Separate from incompatibles.
Containers should be bonded and grounded for transfers to avoid static sparks.
Storage and use areas should be No Smoking areas. Use non-sparking type tools
and equipment, including explosion proof ventilation. Containers of this
material may be hazardous when empty since they retain product residues
(vapors, liquid); observe all warnings and precautions listed for the product.

10. Stability and Reactivity

Stability:Stable under ordinary conditions of use and
storage. Readily absorbs CO2 from the air. Hazardous Decomposition
Products:Carbon oxides, nitrogen oxides and formaldehyde gas form
when heated to decomposition. Hazardous Polymerization:Will
not occur. Incompatibilities:Strong acids and oxidizing
agents; attacks many plastics and rubber. May react with metallic aluminum and
generate hydrogen gas. Conditions to Avoid:Heat, flames,
ignition sources and incompatibles.

11. Toxicological Information

For Tetramethylammonium hydroxide: Skin guinea
pig LD50 = 25 mg/kg Preliminary results from an experimental study in rats
demonstrated lethality following one or more skin applications of
tetramethylammonium hydroxide at dose levels of 50 mg/kg and higher.

12. Ecological Information

Environmental Fate:The following statements refer to
the environmental fate of methanol. When released into the soil, this material
is expected to readily biodegrade. When released into the soil, this material
is expected to leach into groundwater. When released into the soil, this
material is expected to quickly evaporate. When released into water, this
material is expected to readily biodegrade. When released into the water, this
material is expected to have a half-life between 1 and 10 days. When released
into the air, this material is expected to be readily degraded by reaction
with photochemically produced hydroxyl radicals. When released into the air,
this material is expected to be readily removed from the atmosphere by wet
deposition. When released into the air, this material is expected to exist in
the aerosol phase with a short half-life. When released into air, this
material is expected to have a half-life between 10 and 30 days.
Environmental Toxicity:The methanol portion is expected to be
slightly toxic to aquatic life.

13. Disposal Considerations

Whatever cannot be saved for recovery or recycling should be
handled as hazardous waste and sent to a RCRA approved incinerator or disposed
in a RCRA approved waste facility. Processing, use or contamination of this
product may change the waste management options. State and local disposal
regulations may differ from federal disposal regulations. Dispose of container
and unused contents in accordance with federal, state and local requirements.

Australian Hazchem Code: No information found.
Poison Schedule: S6 WHMIS:This MSDS has been
prepared according to the hazard criteria of the Controlled Products
Regulations (CPR) and the MSDS contains all of the information required by the
CPR.

16. Other Information

NFPA Ratings: Health: 3 Flammability: 3
Reactivity: 0Label Hazard Warning:POISON! DANGER!
CORROSIVE. MAY BE FATAL IF SWALLOWED. HARMFUL IF INHALED OR ABSORBED THROUGH
SKIN. CAUSES BURNS TO ANY AREA OF CONTACT. VAPOR HARMFUL. FLAMMABLE LIQUID AND
VAPOR. MAY CAUSE BLINDNESS. CANNOT BE MADE NONPOISONOUS. Label
Precautions:Do not breathe vapor or mist.Do not get in eyes, on
skin, or on clothing.Keep container closed.Keep away from heat, sparks
and flame.Use only with adequate ventilation.Wash thoroughly after
handling. Label First Aid:In case of contact, immediately
flush eyes or skin with plenty of water for at least 15 minutes while removing
contaminated clothing and shoes. Wash clothing before reuse. If inhaled,
remove to fresh air. If not breathing, give artificial respiration. If
breathing is difficult, give oxygen. If swallowed, DO NOT INDUCE VOMITING.
Give large quantities of water. Never give anything by mouth to an unconscious
person. In all cases get medical attention immediately. Product
Use:Laboratory Reagent. Revision Information:MSDS
Section(s) changed since last revision of document include: 3, 11, 16.
Disclaimer:************************************************************************************************
Mallinckrodt Baker, Inc. provides the information contained herein in
good faith but makes no representation as to its comprehensiveness or
accuracy. This document is intended only as a guide to the appropriate
precautionary handling of the material by a properly trained person using this
product. Individuals receiving the information must exercise their independent
judgment in determining its appropriateness for a particular purpose.
MALLINCKRODT BAKER, INC. MAKES NO REPRESENTATIONS OR WARRANTIES, EITHER
EXPRESS OR IMPLIED, INCLUDING WITHOUT LIMITATION ANY WARRANTIES OF
MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE WITH RESPECT TO THE
INFORMATION SET FORTH HEREIN OR THE PRODUCT TO WHICH THE INFORMATION REFERS.
ACCORDINGLY, MALLINCKRODT BAKER, INC. WILL NOT BE RESPONSIBLE FOR DAMAGES
RESULTING FROM USE OF OR RELIANCE UPON THIS INFORMATION.************************************************************************************************
Prepared by:
Environmental Health & SafetyPhone Number: (314) 654-1600 (U.S.A.)