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In 2009, Despaigne had one of the most dominating seasons in Cuban baseball history, breaking the Cuban Home Run record while hitting .373 with 97 RBIs.[2] Following the season, he was named MVP of the National Series. Despaigne was again excellent in 2010,[3] ranking among the best hitters in various statistical categories.[4] In 2012, he set a new Cuban league regular-season home run record, with 35.[5]