Aim: To measure creatine kinase – myocardial band (CK-MB) concentration in stable patients with chronic kidney disease who had not commenced hemodialysis and determine its relationship with cardiac Troponin I and cardiovascular risk factors.

Study Design: Cross-sectional study.

Place and Duration of Study: Renal Unit, Department of Internal Medicine, University of Port Harcourt Teaching Hospital, Rivers State, Nigeria from January 2014 to December 2015.

Conclusion: CK-MB elevation was associated with albuminuria, low HDL and dyslipidemia. However, CK-MB lacked association with cardiac troponin I, which is a more cardiac-specific biomarker. This shows that serum CK-MB levels may not be suitable for diagnosing myocardial injury in CKD patients.