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The Glucose-induced Switch Between Glycogen Phosphorylase and Glycogen
Synthase in the Liver: Outlines of a Theoretical Approach

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The Glucose-induced Switch Between Glycogen Phosphorylase and Glycogen
Synthase in the Liver: Outlines of a Theoretical Approach

Model Status

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Model Structure

The glucose-induced switch between glycogen phosphorylase and glycogen synthase in the liver is
investigated by means of a theoretical approach based on a minimal, bicyclic cascade model involving
the reversible phosphorylation of the two enzymes. The aim of the analysis is to evaluate the
contribution of diﬀerent factors to the sequential changes in the activity of glycogen phosphorylase and
glycogen synthase observed following the addition of suprathreshold amounts of glucose.