BIOLOGICAL investigation of the aqueous methanolic leaf extract ……. of Eugenia supra-axillaris (Myrtaceae) was performed to prove potent hepatoprotective activitiy. Phytochemical investigation led to the characterization of ten phenolic compounds for the first time from this plant. They include the flavonoid glycosides; myricetin 3-O-β-xylopyranosyl (1→2)-α-rhamnopyranoside, myricetin 3-O-α-rhamnopyranoside and quercetin-3-O- α-rhamnopyranoside, the flavonoid aglycones; pinocembrin, myricetin and quercetin, together with phenolics; gallic acid, ellagic acid, 5-O-monogalloylquinic acid and nilocitin. Three phenolics were isolated for the first time from the plants of the genus Eugenia, namely, 5-O-monogalloyl quinic acid, nilocitin and pinocembrin.