What: "Regarding the case in Australia, if the compositions of matter being patented consisted only in Open Reading Frames (ORFs), then it would not be appropriate to characterize them as "genes." Genes contain regulatory sequences, such as promoters, methyl groups, enhancers, and introns. If the ORFs were substantially lacking in these things, or if the ORFs were completely lacking in these things, then it would be the case that the compositions of matter were far removed and distant from what occurs in nature. I am not sure why journalists insist on using the term "genes" to refer to Open Reading Frames. An Open Reading Frame is like a boat that is missing a hull. Because an Open Reading Frame, almost by definition lacks regulatory sequences, the Open Reading Frame would not be able to function properly in its natural environment"