Mouse Study Raises Possibility of New Treatment for Diabetes

WEDNESDAY May 21, 2014, 2014 -- The discovery of a molecule that can help insulin last longer in the body and work more efficiently at lowering blood sugar could lead to a new treatment for diabetes, a new study in mice suggests.

Giving the animals the molecule lowered levels of insulin-degrading enzyme (IDE), which then raised insulin levels, the Harvard University researchers report.

Much more investigation is needed, but the compound may one day help people with diabetes control their disease more effectively, according to the authors of the study published May 21 in the journal Nature.

"This work validates a new potential target for the treatment of diabetes," study co-author David Liu, a professor of chemistry and chemical biology at Harvard, said in a university news release. "What we show is that inhibiting IDE in an animal can improve glucose tolerance under conditions that mimic the intake of a meal if you administer this compound beforehand."

Insulin-based diabetes treatments include insulin injection, drugs that stimulate insulin production or drugs that make the body more sensitive to insulin.

"What's been missing has been the ability to regulate the degradation [breakdown] of insulin," study co-author Alan Saghatelian, an associate professor of chemistry and chemical biology at Harvard, said in the news release. "The technological leap we've made was in identifying a molecule that allows that to happen."

Promising research with animals often fails to provide similar results in humans.

More information

The U.S. National Institute of Diabetes and Digestive and Kidney Diseases has more about diabetes treatments.