Investigators showed that the long non-coding antisense transcript of GATA6 (GATA6-AS) interacts with the epigenetic regulator LOXL2 to regulate endothelial gene expression via changes in histone methylation. Using RNA deep sequencing, they found that GATA6-AS is upregulated in endothelial cells during hypoxia. [Nat Commun]
Full Article

Scientists identified a subset of endoglin-expressing endothelial cells enriched in human bone marrow during fetal ontogeny and upon regeneration after chemotherapeutic injury. Interleukin-33 (IL-33) was significantly overexpressed in these endothelial cells and promoted the expansion of distinct subsets of hematopoietic precursor cells, endothelial cells, as well as osteogenic differentiation. [Cell Rep]
Full Article | Graphical Abstract

Although mitochondrial alterations have been associated to endothelial dysfunction, the role of mitochondrial A kinase anchoring proteins in the vasculature is currently unknown. To test this, postischemic neovascularization, vascular function, and arterial blood pressure were analyzed in Akap1 knockout mice and their wild-type littermates. [Hypertension]
Abstract

Researchers generated a mouse model of vascular malformations by local expression of PIK3CA-activating mutation in endothelial cells. The expression of PIK3CA-activating mutations in human endothelial cells results in both increased proliferation rates and senescence. [Cell Death Dis]
Full Article

Investigators proved that autophagy determines the therapeutic effect of mesenchymal stem cells (MSCs) in cutaneous wound healing through promoting endothelial cells angiogenesis and demonstrated that the paracrine of VEGF in MSCs was required in wound site. [Cell Death Dis]
Full Article

Human retinal microvascular endothelial cells (HRECs) were employed to investigate the impact of miR-210 on the angiogenic capacity of retinal endothelial cells. It was observed that without affecting the viability of HRECs, miR-210 significantly suppressed the migration and capillary-like tube formation in HRECs. [Angiogenesis]
Abstract

Secant Group, in partnership with its sister company SanaVita Medical, announced game changing technology to advance cardiovascular regenerative medicine with the development of a synthetic, small bore, vessel that encourages endogenous regeneration and new vessel formation. [Secant Group, LLC]
Press Release

Amgen and Allergan plc. announced that the European Commission has granted marketing authorization for MVASI®. MVASI is a biosimilar to bevacizumab, a recombinant immunoglobulin G1 monoclonal antibody that binds to VEGF and inhibits the interaction of VEGF with its receptors, VEGF receptor-1 and VEGF receptor-2, thus inhibiting establishment of new blood vessels necessary for the maintenance and growth of solid tumors. [Amgen Inc.]
Press Release

It’s over—at least for the moment. The U.S. Senate voted 81–18 to advance legislation funding government activities, essentially ending a partial government shutdown that had moved into its third day. The House of Representatives is expected to follow suit, sending the bill to President Donald Trump for his signature. [ScienceInsider]
Editorial

A new online tool measures the reproducibility of published scientific papers by analyzing data about articles that cite them. The software comes at a time when scientific societies and journals are alarmed by evidence that findings in many published articles are not reproducible and are struggling to find reliable methods to evaluate whether they are. [ScienceInsider]
Editorial

A new front has opened in the war on science in India. India’s minister for higher education, Satyapal Singh, took aim at the theory of evolution. Calling himself “a responsible man of science,” Singh, a chemist, suggested that Darwin’s theory is “scientifically wrong” and “needs to change” in school and university curricula. [ScienceInsider]
Editorial