Improved Estimation of the Radius of Gyration from Small-Angle X-Ray Scattering Data

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Abstract

Small-angle X-ray scattering (SAXS) is an experimentally simple technique that provides access to low-resolution information about biological macromolecules in solution. We here provide R code and example data sets for a new algorithm that produces accurate and precise values for the radius of gyration, Rg, of a particle. Theory states that the information derived from the lowest scattering angles can be used to estimate Rg. The value Rg is a fundamental structural parameter that is related to a molecule's size and shape. The original algorithm implemented with the R code estimates Rg with a ...