Dr. Hannibal Lektor: If one does what God does enough times, one will become as God is.

Will Graham: I know that I'm not smarter than you.Dr. Hannibal Lektor: Then how did you catch me?Will Graham: You had disadvantages.Dr. Hannibal Lektor: What disadvantages?Will Graham: Passion. And you're insane.

Will Graham: It's just you and me now, sport.

Jack Crawford: You feel sorry for him.Will Graham: As a child, my heart bleeds for him. Someone took a little boy and turned him into a monster. But as an adult... as an adult, he's irredeemable. He butchers whole families to fulfill some sick fantasy. As an adult, I think someone should blow the sick f**k out of his socks.

Dr. Hannibal Lektor: You want the scent? Smell yourself!

Trivia:

The prison where Hannibal Lecter is being incarcerated is the High Museum of Art in Atlanta.

The film was originally to be entitled "Red Dragon" after the novel, but when Year of the Dragon flopped, Dino de Laurentiis decided to avoid a "dragon" title.