Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

CONCLUSION: Repeated EA has a cumulative analgesic effect in CCI rats, which is probably related to its resultant upregulation of PKAexpression in neurons of hypothalamus and hippocampus and the animals' neuro-memory.

Our findings indicate that primary culture from PTZ-induced seizure model triggers robust caspase-3 activation, release of cytochrome-c and decrease GABAB1R expression which has further decreasing effect on PKA expression level in hippocampal neurons of prenatal rat brain, while the co treatment of baclofen and phaclofen reverse the effects of PTZ and provide neuroprotection.

In addition, during the persistent hypernociceptive state, the PKA and PKCvarepsilon expression and activity in the DRG are up-regulated and the administration of the PKA and PKCvarepsilon inhibitors reduce the hypernociception as well as the Na(V)1.8 mRNA level.

To combine the finding of the increasedexpression of PKA in PSDCneurons, we could suggest that a possible role for PKA in regulation of AMPA receptor activity in PSDC neurons during visceral painful states.

CONCLUSION: Repeated EA has a cumulative analgesic effect in CCI rats, which is probably related to its resultant upregulation of PKAexpression in neurons of hypothalamus and hippocampus and the animals' neuro-memory.