In direct seeded rice (DSR), flushes of weeds are encountered, and mostly subsequent herbicides need to apply to control weeds that appear later. A farmer friendly approach was hypothesized in present study to integrate the management strategies for water, soil and cost effective weed free rice production. Efficacy of various herbicides in weed control to improve the performance of aerobic rice grown under varying tillage and alternate water regimes was evaluated. Five weed management techniques (weedy check, weed-free, pendimethalin followed by manual weeding, pendimethalin + bispyribac sodium (BS) + bensulfuron (B) and pendimethalin + MCPA) were carried out within the alternate wetting and drying (AWD) regimes (15 and 20 cm depth) under two tillage systems (zero and conventional). All the herbicide treatments reduced the weed intensity as compared to weedy check, however minimum weed density and dry biomass was observed in pendimethalin at 40 and 60 days after sowing, respectively. Under conventional tillage, weed free plots showed maximum leaf area index, leaf area duration and crop growth rate. Maximum plant height, 1000-kernel weight and kernel per panicle along with less percentage of abortive, chalky and opaque kernels were recorded in pendimethalin followed by BS+B as compared to weedy check plots. Among the herbicides application, pendimethalin followed by BS+B gave highest benefit to cost ratio and net benefits under both AWD regimes. Overall, application of pendimethalin followed by BS+B is an efficient and economic approach to reduce weed infestation which results in improved yield of aerobic rice.