Olanzapine is an antipsychotic medication used to treat schizophrenia and bipolar disorder. It is usually classed with the atypical antipsychotics, the newer generation of antipsychotics. It appears to have slightly greater effectiveness in treating schizophrenia (especially the negative symptoms) and a lower risk of causing movement disorders than typical antipsychotics. Olanzapine, however, has a higher risk of causing metabolic side effects like weight gain and type 2 diabetes than the typical antipsychotics.

Olanzapine is structurally similar to clozapine and quetiapine.

It is chemically classified as a thienobenzodiazepine. It is believed to work by blocking, or antagonizing, the dopamine D2 receptor which is an action it shares with all presently-approved antipsychotics.

Like most other atypical antipsychotics olanzapine also strongly antagonizes the 5-HT2A receptor, which may partially underpin its reduced propensity for causing movement disorders. Despite its close structural relation to traditional benzodiazepine anxiety-relieving medications, it possesses no affinity for the GABAA receptor, its anxiety-relieving effect is mediated through its effect on dopamine and 5-HT receptors.

3. Product Applications:

The first-line psychiatric treatment for schizophrenia is antipsychotic medication which includes olanzapine. Olanzapine appears effective in reducing symptoms of schizophrenia, treating acute exacerbations, and treating early-onset schizophrenia. The usefulness of maintenance therapy, however, is difficult to determine as more than half of people in trials quit before the six-week completion date.

Olanzapine treatment may result in increased weight gain and increased glucose and cholesterol levels when compared to most other second-generation antipsychotic drugs used to treat schizophrenia, other than clozapine.

4. Test Report:

Item

Specifications

Results

Appearance

Yellow crystal or crystalline powder

Yellow crystalline powder

Indentification

A. The IR spectrum corresponds to reference standard.

Conforms

B. The retention time of the major peak of the sample solution corresponds to that of the Standard solution, as obtained in the Assay.

Conclusion: This product conforms to specification of USP 36 standard.

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