The Gaziantep Museum of Archaeology (Turkish: Gaziantep Arkeoloji Müzesi) is an archaeological museum located in the city of Gaziantep, Turkey. It is best known for its collection of mosaics, most of which were excavated from the ancient Roman city site of Zeugma. Other exhibits include a collection of paleolithic artifacts; items from a Bronze Agenecropolis; Hittite, Persian, Roman, Hellenistic, and Commagene artworks and glassware; Ottoman and Islamic coins and medallions; and the skeleton of a mammoth. Attached to the museum is a garden containing a selection of stone artifacts, including pagan tombstones from Zeugma, Christian tombstones, and Hittite statuary.

The museum in its current form dates from 2005, when it was substantially enlarged to house the newly discovered Zeugma mosaics.