MEDICINAL CHEMISTRY-SYNTHESIS OF POTENTIAL TREATMENT AGENTS FORCOCAINE ADDICTION
NIH GUIDE, Volume 26, Number 10, March 28, 1997
RFP AVAILABLE: N01DA-7-8077
P.T. 34
Keywords:
Drugs/Drug Abuse
Addiction
Chemical Synthesis
Biometry
Inhibitors
National Institute on Drug Abuse
The National Institute on Drug Abuse (NIDA) is soliciting proposals
from qualified organizations having the capability to design and
synthesize compounds which affect primarily dopaminergic systems and
either substitute for cocaine or antagonize its effects. The project
shall involve the synthesis of any of the following: dopamine uptake
inhibitors with a slower rate of onset than cocaine; compounds which
affect dopaminergic systems through the inhibition of dopamine or
serotonin transporters; serotonin transporter selective cocaine
analogs; dopamine partial agonists, agonists, and antagonists; and
dopamine sparing cocaine antagonists (compounds that bind to the
dopamine transporter without inhibiting dopamine uptake); and
compounds selective for D1 and D3 receptors. The project shall also
provide for the scale-up production, and analog synthesis, of
promising compounds. The major goal of this project is to provide
NIDA with a resource of novel compounds with potential use in the
treatment of cocaine abuse. It is anticipated that six cost
reimbursement, term type contracts will be awarded for a period of
two years, with two one-year options. This requirement is a partial
set-aside for small business, i.e., three of the awards will be made
to small businesses.
RFP No. N01DA-7-8077 will be available electronically on or about
April 14, 1997, and may be accessed through the NIH Gopher and/or the
Internet by using the following electronic mail addresses and
instruction:
1. NIH Home Page (via the World Wide Web): Access the NIH Home Page
by using http://www.nih.gov . Once you are at the NIH Home Page,
select "Grants and Contracts"; select NIH Gopher directory: listed
under the "Contracts Page" section. Once at the NIH R&D Gopher,
select "RFPs Available"; select "NIDA"; and select "RFP N01DA-7-
8077". (URL: gopher://gopher.nih.gov:70/11/res/rd-rfp)
2. NIH Gopher: Point your Gopher client to GOPHER.NIH.GOV Port 70
(you should now be in the NIH Gopher). Select "Grant and Research
Information"; select "R&D Request for Proposals (RFP)"; select "RFPs
Available"; select "NIDA"; and, select "RFP N01DA-7-8077".
Please note that the RFP for this acquisition will be streamlined to
include only the Work Statement, deliverable and reporting
requirements, special requirements and mandatory qualifications,
Technical Evaluation Criteria, and proposal preparation instructions.
All information required for the submission of an offer will be
contained in the electronic RFP package. Response to this RFP will
be due on or about May 29, 1997. Any responsible offeror may submit
a proposal which will be considered by the Government. This
advertisement does not commit the Government to award a contract.
INQUIRIES
Kenneth E. Goodling
Contracts Management Branch
National Institute on Drug Abuse
5600 Fishers Lane, Room 10-49
Rockville, MD 20857
Telephone: (301) 443-6677
FAX: (301) 443-7595
Email: kg25d@nih.gov
.