Hoes and colleagues [1] concluded that “the use of non-potassium-sparing diuretics and β-blockers is associated with an increased risk for sudden cardiac death.” Their data, however, do not fully support (or at least explain) this conclusion. First, none of the “bivariate” associations (their Table 2 between exposure to various categories of diuretic or β-blocker use and outcome as case–control status were clinically or statistically significant. For example, 21.8% of case-patients [n = 56] were taking non-potassium-sparing diuretics, regardless of β-blocker use, compared with 17.9% of controls (n = 46) (odds ratio, 1.5 [95% CI, 0.9 to 2.4]). The other associations had similarly small and nonsignificant distinctions between case-patients and controls. Thus, one interpretation of the study results is that the study is essentially “negative” and does not warrant further analysis.