Jess and Chester wake up one morning after a night of partying and the nightmare begins: Their stash is gone, Jesse's car is gone, their girlfriends - the twins - are mad and the boys can't remember anything from the night before. They set out on a whirlwind journey to figure out what happened. As Jesse and Chester retrace their steps they discover that the night before they had- and lost - a suitcase full of cash, they met a gorgeous gender-challenged stripper and six sexy alien women, and now they are caught up in the middle of an intergalactic war with the fate of the universe in their hands!
Rated PG-13 for language and some sex and drug-related humor.