It is possible that the polymorphism at the adjacent TACR3 may be somehow involved in increasing expression of TLR2 in rosacea and therefore in upregulation of KLK5 in a calcium-dependent manner; possibly PP rosacea patients overreact, resulting in the histogenesis ofrosacea papules and pustules, even though bacterial diversity and quantities are similar in rosacea lesions and in normal skin [34].

Previously, several other kallikreins, including KLK4, KLK5, KLK6, KLK7, KLK8, KLK9, KLK10, KLK11, KLK14, and KLK15, have been associated with various forms of malignancy and especially cancers of the ovary, breast, prostate, and testis [reviewed in Refs.

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