The inhibitory potency of acetyl-Asp-Glu-Val-Asp-aldehyde ('Ac-DEVD-CHO'), benzyloxycarbonyl-Val-Ala-Asp-fluoromethylketone ('Z-VAD-FMK') and the endogenous caspase inhibitor X-chromosome-linked inhibitor of apoptosis protein ('XIAP') against recombinant caspase-9 were predictive of the efficacy of these compounds in a cell-free system. (biochemj.org)

The evasion from apoptosis, or programmed cell death, is an invariant molecular trait of human cancer (1) , which may facilitate the acquisition of additional cancer traits (2) promoting resistance to therapy and disseminated disease. (aacrjournals.org)

Thus, we now show that selection for interferon resistance can generate cells with increased expression of cFLIP, which protects the cells from both IFN-α and death receptor mediated apoptosis. (diva-portal.org)

In Hq mice, instead of supernumerary cells attributable to failed apoptosis, surprisingly their cerebellum degenerates progressively and Hq neurons are more sensitive to oxidative stress. (jneurosci.org)