..The topic of ILD or diffuse infiltrative lung disease covers several hundred entities. This article is meant to be a launching point in the clinician's approach to the histologic evaluation of lung disease...

John R GreenlandDepartment of Medicine, University of California at San Francisco, San Francisco, CA 94121, USAAm J Respir Crit Care Med 187:417-23. 2013

..Although acute rejection and lymphocytic bronchiolitis have been identified as risk factors for the development of BOS, it is unclear whether large-airway lymphocytic inflammation conveys the same risk...

A multidimensional index and staging system for idiopathic pulmonary fibrosis

..Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disease with an overall poor prognosis. A simple-to-use staging system for IPF may improve prognostication, help guide management, and facilitate research...

..Gastroesophageal reflux (GER) is highly prevalent in patients with idiopathic pulmonary fibrosis (IPF). Chronic microaspiration secondary to GER may play a role in the pathogenesis and natural history of IPF...

Pathogenesis of idiopathic pulmonary fibrosis

Paul J WoltersDepartment of Medicine, School of Medicine, University of California, San Francisco, California 94143 emailAnnu Rev Pathol 9:157-79. 2014

..We then discuss the pathologic changes within IPF fibroblasts and the extracellular matrix, and we conclude with a summary of how these profibrotic pathways may be interrelated. ..

A practical molecular assay to predict survival in resected non-squamous, non-small-cell lung cancer: development and international validation studies

James A FrankCardiovascular Research Institute and the Department of Medicine, University of California, San Francisco, San Francisco, California 94143 0130, USAAm J Respir Crit Care Med 165:242-9. 2002

..The additional decrease in pulmonary edema with a tidal volume of 3 ml/kg is partly accounted for by greater protection of the alveolar epithelium...

..A correlation was seen between prior ventilation and/or biopsy. These findings may indicate that PIE is a result of medical intervention; however, in the remainder of cases the disease process itself may have been a contributing factor. ..

..This historical perspective traces the history of the term lepidic from its origins at McGill University in Montreal, Canada, through its uses in English pathologic descriptions, to its current state in pulmonary pathology. ..

MicroRNA-494 within an oncogenic microRNA megacluster regulates G1/S transition in liver tumorigenesis through suppression of mutated in colorectal cancer

Lionel LimDepartment of Cell and Tissue Biology, University of California San Francisco, San Francisco, CA Department of Medicine, University of California San Francisco, San Francisco, CAHepatology 59:202-15. 2014

..The resultant standardization of cancer reporting would be expected to benefit not only those countries directly involved in the collaboration but also others not in a position to develop their own data sets...

..The clinical associations and prognostic value of cough in IPF have not been adequately described. The objective of this study was to describe the characteristics and prognostic value of cough in IPF...

Interaction between MYC and MCL1 in the genesis and outcome of non-small-cell lung cancer

..Our findings therefore produce a convergence of mouse and human results that explain how MCL1 can block an important negative consequence of MYC overexpression in both experimental models and clinical cases of NSCLC...

The diagnosis and management of intradiaphragmatic extralobar pulmonary sequestrations: a report of 4 cases

..Acquired autoimmune connective tissue diseases will be covered in this review, while lung involvement in vasculitides, heritable connective tissue disorders, and drug-induced CTD-like conditions will not be discussed. ..

..This case of donor-transmitted malignancy underscores the need for vigilance by the procuring surgeon in identifying potential malignancy during organ retrieval and use of a full autopsy on selected donors after organ procurement...