Proteomics is an exciting area of research that holds promise for the future. It is widely accepted that proteomics holds the potential to identify new diagnostic and or prognostic biomarkers, and... More > drug targets for the development of new therapeutic approaches for fighting disease. Proteomics, the large scale analysis of gene expression at the protein level incorporates structural, interaction and expression proteomics. Using expression proteomics, the aim is to detect and identify all, or a subset, of the proteins in a given sample and find out which of these proteins are present, absent, or differentially expressed in a related sample subject to as specific variation.… Meeting’s Chair: Dr Ayesha De Souza, St. George's, University of London, UK.< Less

Proteomics is an exciting area of research that holds promise for the future. It is widely accepted that proteomics holds the potential to identify new diagnostic and or prognostic biomarkers, and... More > drug targets for the development of new therapeutic approaches for fighting disease. Proteomics, the large scale analysis of gene expression at the protein level incorporates structural, interaction and expression proteomics. Using expression proteomics, the aim is to detect and identify all, or a subset, of the proteins in a given sample and find out which of these proteins are present, absent, or differentially expressed in a related sample subject to as specific variation.… Meeting’s Chair: Dr Ayesha De Souza, St. George's, University of London, UK.< Less

Urinary 1,6-hexamethylene diamine (HDA) has been indicated as a potential biomarker for systemic exposure to 1,6-hexamethylene diisocyanate (HDI). Our objective was to establish a quantitative and... More > time-dependent relationship between urine HDA levels and inhalation and dermal exposure to HDI. Urine HDA levels, creatinine concentrations, and specific gravity along with dermal and breathing-zone levels of HDI were measured in automotive spray painters. Dermal exposure and inhalation exposure levels, adjusted for the type of respirator worn, and creatinine concentration were observed to be significant predictors of urine HDA levels. The use of coveralls, type of respirator worn, smoker status, type of painting booth, and multiple painters at the shop were found to significantly affect urine HDA. Our results indicate that urine HDA is a useful biomarker for systemic HDI exposure through the skin and lungs and emphasize the need for proper dermal and inhalation protection for workers.< Less

Urinary 1,6-hexamethylene diamine (HDA) has been indicated as a potential biomarker for systemic exposure to 1,6-hexamethylene diisocyanate (HDI). Our objective was to establish a quantitative and... More > time-dependent relationship between urine HDA levels and inhalation and dermal exposure to HDI. Urine HDA levels, creatinine concentrations, and specific gravity along with dermal and breathing-zone levels of HDI were measured in automotive spray painters. Dermal exposure and inhalation exposure levels, adjusted for the type of respirator worn, and creatinine concentration were observed to be significant predictors of urine HDA levels. The use of coveralls, type of respirator worn, smoker status, type of painting booth, and multiple painters at the shop were found to significantly affect urine HDA. Our results indicate that urine HDA is a useful biomarker for systemic HDI exposure through the skin and lungs and emphasize the need for proper dermal and inhalation protection for workers.< Less

Long-term exposures to toxic chemicals can pose risks to human health. In order to properly assess and minimize such risks, it is necessary to measure chemical levels in the air or other... More > environmental media. Since exposure levels vary across groups, between persons (in a given group), and within persons (over time), appropriate statistical analysis of exposure data typically requires the use of linear mixed effects models. This book applies such statistical models to exposure data, with emphasis upon airborne chemical exposures in the workplace and in the ambient environment.< Less

Abstract
Background: Dementia drug development aims to modulate pathological processes that cause clinical syndromes. Population data (epidemiological neuropathology) will help to model and predict... More > the potential impact of such therapies on dementia burden in older people. Presently this can only be explored through post mortem findings. We report the attributable risks (ARs) for dementia at death for common age-related degenerative and vascular pathologies, and other factors, in the MRC Cognitive Function and Ageing Study (MRC CFAS).
Methods and Findings: A multicentre, prospective, longitudinal study of older people in the UK was linked to a brain donation programme.
Conclusions: Such AR estimates cannot be derived from the living population; rather they estimate the relative contribution of specific pathologies to dementia at death. We found that multiple pathologies determine the overall burden of dementia.< Less

The purpose of this text is to depict and analyze the photoreceptor integrity line (PIL) or the IS/OS junction of the inner and outer segments in the normal and abnormal eyes with macula and retinal... More > diseases. This book includes 67 cases that fall into the following categories; congenital, acquired, retinal vascular disorders, hereditary chorioretinal dystrophies, myopic degeneration and age related macular degeneration. In each case presented, the PIL/junction serves as a biomarker that represents the integrity of both rods and cones.< Less

The purpose of this text is to depict and analyze the photoreceptor integrity line (PIL) or the IS/OS junction of the inner and outer segments in the normal and abnormal eyes with macula and retinal... More > diseases. This book includes 67 cases that fall into the following categories; congenital, acquired, retinal vascular disorders, hereditary chorioretinal dystrophies, myopic degeneration and age related macular degeneration. In each case presented, the PIL/junction serves as a biomarker that represents the integrity of both rods and cones.< Less

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