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Divine fortune, also known as guidance, is a channel divinityprayer cast by all clerics. When divine fortune is cast the cleric using it becomes, for a moment, more resistant to ill effects while simultaneously gaining additional combat proficiency. After the effects have worn off, divine fortune cannot be recast, nor can any other channel divinity prayer be cast, until the cleric rests for at least a few minutes, in order to regain the concentration needed for the casting.

Prior to the Spellplague, divine fortune was more commonly known as guidance and was slightly less powerful, being considered an orison. It could also only be cast a number of times per day equal to the number of times a cleric had prepared for its usage. There was also a similar evocation used by druids.[2]