Newbie question. Which distro best to use

Interested in getting started and trying to figure out which distro would allow me to use all features like the multiserver. I see various distro installs for ISPconfig on separate servers, but it seems like the multiserver articles refer only to Debian. I have only used Centos before but if something is better to ensure success with ISPconfig I would appreciate some input before I get going. I like the concept of a centralized multisever setup and since I use xenserver this would be a good fit.