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Abstract

Digital Tomosynthesis Mammography (DTM) is an emerging technique that has the potential to
improve breast cancer detection. DTM acquires low-dose mammograms at a number of projection angles
over a limited angular range and reconstructs the 3D breast volume. Due to the limited number of projections
within a limited angular range and the finite size of the detector, DTM reconstruction contains boundary and
truncation artifacts that degrade the image quality of the tomosynthesized slices, especially that of the
boundary and truncated regions. In this work, we developed artifact reduction methods that make use of both
2D and 3D breast boundary information and local intensity-equalization and tissue-compensation techniques.
A breast phantom containing test objects and a selected DTM patient case were used to evaluate the effects
of artifact reduction. The contrast-to-noise ratio (CNR), the normalized profiles of test objects, and a non-uniformity
error index were used as performance measures. A GE prototype DTM system was used to
acquire 21 PVs in 3° increments over a ±30° angular range. The Simultaneous Algebraic Reconstruction
Technique (SART) was used for DTM reconstruction. Our results demonstrated that the proposed methods
can improve the image quality both qualitatively and quantitatively, resulting in increased CNR value,
background uniformity and an overall reconstruction quality comparable to that without truncation. For the
selected DTM patient case, the obscured breast structural information near the truncated regions was
essentially recovered. In addition, restricting SART reconstruction to be performed within the estimated 3D
breast volume increased the computation efficiency.

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Advanced PhotonicsJournal of Applied Remote SensingJournal of Astronomical Telescopes Instruments and SystemsJournal of Biomedical OpticsJournal of Electronic ImagingJournal of Medical ImagingJournal of Micro/Nanolithography, MEMS, and MOEMSJournal of NanophotonicsJournal of Photonics for EnergyNeurophotonicsOptical EngineeringSPIE Reviews