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Mitragyna speciosa is a leafy tree that grows from 3-20 meters tall. Its leaves contain 7-Hydroxymitragynine and mitragynine. The leaves are chewed as an opiate substitute and stimulant in Thailand and South-East Asia, primarily among the working class. It has a relatively long history of human use.

Oct 12, 2016: The DEA has withdrawn the notice of intent to schedule kratom's constituent psychoactives and is soliciting public comment until Dec 1 2016.