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Mar Yosip Khnanisho (Syriac: ܡܪܝ ܝܘܣܦ ܚܢܢܝܫܘܥ), the metropolitan or matran of Shemsdin, was a holy man from the Mar Khnanishu family. He studied with Rev. Rehana, the head of the Seminary in Mar Ishu Monastery. Mar Yosip was ordained a deacon at age 12 and ordained as a priest in 1912. In 1914, he was sent as a delegate to participate in a meeting at the patriarchal cell in Qudchanis to discuss the effects of the World War on the Church and the nation and prepare for the changes that were expected to take place. While there he was consecrated a Bishop on August 10, 1914, He remained in Qudchanis until 1916.

In 1918 was appointed as assistant to the Patriarch Mar Shimun XXII Paulos as Locum Tenens.
In December 1918 he was elevated to the rank of Metropolitan in Baghdad Iraq, by the Patriarch.

In 1933, he was made administrator of the Church in Iraq and the Middle East. In 1973 when Mar Eshai Shimun XXIII resigned his position as Catholicos Patriarch of the Assyrian Church of the East, Mar Yosip Khnanisho was vested with responsibilities of administering the Church worldwide. At the same time the Iraqi government issued a Republican decree appointing Mar Yosip Khnanisho as the Supreme Head of all the Assyrians in Iraq.

On the 3 July 1977, Yosip died in Baghdad, Iraq. His funeral services were conducted on 6 July 1977, at the Church of Mar Gewargis in Dora, a suburb of Baghdad.