Third-generation cephalosporins as antibiotic prophylaxis in neurosurgery: What's the evidence?

To analyze the role of third-generation cephalosporins as prophylactic antibiotics in neurosurgery. We reviewed the literature for data from randomized controlled trials (RCTs) on third-generation cephalosporins compared to other antibiotic regimen in neurosurgery. End point of the RCTs was the occurrence of surgical site infections (SSIs) – data were pooled in a fixed-effects meta-analysis.