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CRASH2 Trial Results Out - Tranexamic Acid Recommended

CRASH2 Trial Results Out - Tranexamic Acid Recommended

The results of the international CRASH-2 trial, show that early administration of tranexamic acid (TXA) to patients with recent, severe bleeding injuries saves lives, with no evidence of adverse effects from unwanted clotting.

The CRASH-2 trial was a large, randomised trial involving over 20,000 adult patients in 274 hospitals across 40 countries. It is the first trial of TXA in injured patients, although smaller trials have shown that it reduces bleeding in surgical patients.

Severely injured adults were enrolled in the trial if they had significant bleeding, or were at risk of significant bleeding and were within a few hours of injury. They were randomly allocated to receive either one gram of TXA by injection, followed by another one gram in a drip over the following eight hours, or a matching placebo. The researchers studied the numbers of deaths in hospital within four weeks of injury in the two groups and found that TXA reduced the chances of death due to massive blood loss by about one sixth.