Effects of telmisartan on oxidative stress and vascular endothelial function in patients with coronary slow flow

Objective To investigate the effects of telmisartan on oxidative stress and vascular endothelial function in patients with coronary slow flow(CSF).Methods One hundred and twenty six patients with CSF and normal coronary angiography were selected.All the patients were randomly divided into conventional treatment group and telmisartan group,63 cases in each group.Patients in conventional treatment group were given conventional treatment(aspirin,nitrates and atorvastatin),while patients in the telmisartan group were given telmisartan on the basis of conventional treatment.TIMI,malondialdehyde(MDA);reactrve oxygen species(ROS);superoxide dismutase(SOD).endothelial dependent flow mediated vasodilation(FMD),endothelin 1(ET-1),nitric oxide(NO) were observed in the two groups before and after eight weeks of treatment.Results TIMI reduced significantly in the telmisartan group after treatment compared with before treatment and conventional group after treatment(t =7.384,t =6.932,P =0.001,P =0.004).SOD,FMD,NO improved in the telmisartan group after treatment compared with before treatment(t = 5.631,t =5.922,t = 5.691,P =0.00,P =0.000,P =0.002),MDA,ROS,ET llevel decreased(t =6.462,t =7.281,t =6.970,P =0.001,P =0.004,P =0.005).TIMI,SOD,MDA,ROS,FMD,NO,ET-1 of conventional treatment had no significantly changes before and after treatment(t =0.471,t = 0.722,t =0.350,t =0.193,t =0.873,t =0.554,t =0.381,P =0.530,P =0.568,P =0.466,P =0.357,P =0.580,P =0.457,P =0.371).The post treatment of SOD,FMD,NO in telmisartan group were significantly increased with conventional group(t =4.064,t =5.091,t =4.270,P =0.000,P =0.017,P =0.007),TIMI,MDA,ROS,ET-1 levels in telmisartan group were significantly reduced with conventional group(t =6.932,t =4.181,t=4.360,1=7.944,P-0.004,P =0.002,P =0.007,P =0003).Conclusion The telmisartan group curative effect is significantly better than that of conventional group in the treatment of CSF,telmisartan may play a role in the mechanism of inhibition of oxidative stress response and improving the vascular endothelial function.