Additional Human Studies

2015

This study looked at the effect of 12 weeks of HMB supplementation, with and without resistance training (RT), on abdominal adiposity in elderly men. Forty-eight men 66 to 78 years of age were assigned in a factorial design to either no exercise-placebo, RT-placebo, no exercise-HMB, or RT-HMB. After 12 weeks the RT-HMB group had significantly less abdominal adiposity when compared to the other treatment groups. This study suggests that HMB combined with 12 weeks of RT decreases abdominal adiposity in elderly men.

2004

Consumption of HMB, arginine, and glutamine by healthy, AIDS patients and cancer patients was studied. No adverse effects were seen and the mixture enhanced hematological parameters such as red blood cell numbers.

2002

In this multi-center study, a combination of HMB, arginine, and glutamine was shown to improve body composition in cancer wasting by targeting nutrition to increase protein synthesis and decrease protein degradation.

2001

In hypercholesterolemic men participating in an exercise program, HMB decreased LDL cholesterol by 28 percent as well as increasing strength and improving body composition. No changes in LDL were seen in the placebo group.

2000

AIDS patients, who had previously lost body weight, gained back body weight and improved body composition as well as increased T-cells and decreased viral load when they consumed a dietary supplement containing HMB, arginine, and glutamine in this eight-week clinical study.

1999

HMB and Betagen (HMB and creatine) were the only supplements shown to decrease muscle soreness after downhill running, and HMB, creatine, and Betagen all decreased the loss in strength associated with the running.

1997

This paper reviews the first seven human studies with HMB and summarizes health and safety data generated as well as the muscle and strength gain data from these studies. The only significant changes in blood chemistry are decreases in total and LDL cholesterol.

In two separate studies, one with and one without exercise, women were supplemented with HMB. No effect of HMB on body composition was measured in the non-exercising group of women, but in women undergoing exercise, HMB improved body composition and had increased fat loss, and strength gains.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Individuals providing testimonies are sponsored athletes or have received the ingredient HMB (ß-hydroxy ß-methylbutyrate) as a gift from Metabolic Technologies, Inc.