PEOPLE'S PHARMACY: New drugs don’t deliver on promise

By Joe and Teresa Graedonwww.PeoplesPharmacy.com

Published: Thursday, March 21, 2013 at 3:30 a.m.

Last Modified: Wednesday, March 20, 2013 at 4:56 p.m.

What happened to all the drug breakthroughs? Whenever Americans complain about the high cost of prescription medicines, they are told that their “investment” in brand-name drugs will lead to crucial advances in hard-to-treat diseases. This promise remains largely unfulfilled.

During the past few decades, pharmaceutical manufacturers have consolidated. Giant firms swallowed smaller corporations. Bigger was supposed to be better and lead to innovative compounds.

Nowhere is the disappointment greater than in the dearth of effective treatments for mental illness. There are dozens of drugs on the market for schizophrenia, depression, bipolar disorders and Alzheimer’s disease. Americans spent more than $25 billion on such medications last year. None of the available medications is a clear breakthrough, and most have serious side effects.

Second-generation antipsychotics were launched with great fanfare roughly 20 years ago. Drugs like clozapine (Clozaril) and risperidone (Risperdal) were supposed to be much better than older drugs like chlorpromazine (Thorazine), haloperidol (Haldol) and thioridazine (Mellaril).

The side effects from these older medications were unbearable for many patients. Some people felt like zombies because of the sedation, confusion and extreme restlessness. These drugs could produce uncontrollable muscle tics that would make people grimace or stick out their tongues. Such movements were frequently irreversible, even after the drug was stopped. Side effects of dizziness, dry mouth, constipation, urinary retention, blurred vision, fainting, heart palpitations, seizures and sexual problems added to the patients’ woes.

Clozaril, Risperdal and the medications that followed them, such as aripiprazole (Abilify), olanzapine (Zyprexa), quetiapine (Seroquel) and ziprasidone (Geodon), were supposed to be much easier to tolerate. Many patients and physicians also expected that they would be more effective.

But even these new “atypical” antipsychotics have serious side effects like weight gain that may trigger diabetes and heart disease. Sadly, these pricey medicines don’t seem to work any better than older drugs (Journal of Clinical Psychopharmacology, October 2012).

As disappointing as the anti-psychotics have been, drugs to treat Alzheimer’s disease are worse. Recent studies have produced dismal results when it comes to improving memory and ability to function.

Even antidepressants have come under scrutiny. Although millions swallow pills such as citalopram (Celexa), duloxetine (Cymbalta), escitalopram (Lexapro), fluoxetine (Prozac), sertraline (Zoloft) and venlafaxine (Effexor), many find that the drugs are only moderately effective or lose their antidepressant power after a time.

Side effects of such anti-

depressants can include nausea, dizziness, fatigue, dry mouth, insomnia, anxiety, sweating, headache and sexual difficulties, to name just a few. Stopping such drugs can be challenging because of “discontinuation syndrome,” also known as withdrawal.

Americans with mental illness deserve better. It’s time drug manufacturers became more creative in their search for new treatments.

Write to Joe and Teresa Graedon via their website: www.PeoplesPharmacy.com.

<p>What happened to all the drug breakthroughs? Whenever Americans complain about the high cost of prescription medicines, they are told that their “investment” in brand-name drugs will lead to crucial advances in hard-to-treat diseases. This promise remains largely unfulfilled.</p><p>During the past few decades, pharmaceutical manufacturers have consolidated. Giant firms swallowed smaller corporations. Bigger was supposed to be better and lead to innovative compounds.</p><p>Nowhere is the disappointment greater than in the dearth of effective treatments for mental illness. There are dozens of drugs on the market for schizophrenia, depression, bipolar disorders and Alzheimer's disease. Americans spent more than $25 billion on such medications last year. None of the available medications is a clear breakthrough, and most have serious side effects.</p><p>Second-generation antipsychotics were launched with great fanfare roughly 20 years ago. Drugs like clozapine (Clozaril) and risperidone (Risperdal) were supposed to be much better than older drugs like chlorpromazine (Thorazine), haloperidol (Haldol) and thioridazine (Mellaril).</p><p>The side effects from these older medications were unbearable for many patients. Some people felt like zombies because of the sedation, confusion and extreme restlessness. These drugs could produce uncontrollable muscle tics that would make people grimace or stick out their tongues. Such movements were frequently irreversible, even after the drug was stopped. Side effects of dizziness, dry mouth, constipation, urinary retention, blurred vision, fainting, heart palpitations, seizures and sexual problems added to the patients' woes.</p><p>Clozaril, Risperdal and the medications that followed them, such as aripiprazole (Abilify), olanzapine (Zyprexa), quetiapine (Seroquel) and ziprasidone (Geodon), were supposed to be much easier to tolerate. Many patients and physicians also expected that they would be more effective.</p><p>But even these new “atypical” antipsychotics have serious side effects like weight gain that may trigger diabetes and heart disease. Sadly, these pricey medicines don't seem to work any better than older drugs (Journal of Clinical Psychopharmacology, October 2012).</p><p>As disappointing as the anti-psychotics have been, drugs to treat Alzheimer's disease are worse. Recent studies have produced dismal results when it comes to improving memory and ability to function.</p><p>Even antidepressants have come under scrutiny. Although millions swallow pills such as citalopram (Celexa), duloxetine (Cymbalta), escitalopram (Lexapro), fluoxetine (Prozac), sertraline (Zoloft) and venlafaxine (Effexor), many find that the drugs are only moderately effective or lose their antidepressant power after a time.</p><p>Side effects of such anti-</p><p>depressants can include nausea, dizziness, fatigue, dry mouth, insomnia, anxiety, sweating, headache and sexual difficulties, to name just a few. Stopping such drugs can be challenging because of “discontinuation syndrome,” also known as withdrawal.</p><p>Americans with mental illness deserve better. It's time drug manufacturers became more creative in their search for new treatments.</p><p></p><p>Write to Joe and Teresa Graedon via their website: www.PeoplesPharmacy.com.</p>