One study found no significant association between the rs17125944 polymorphism and late-onset Alzheimer's disease (LOAD) in a Chinese Han population, with or without stratification by apolipoprotein E (APOE) ε4 genotype and multivariate logistic regression analysis. When the investigators performed a meta-analysis in 81908 individuals including their study population, they confirmed a previously-reported association between the C allele and LOAD in Caucasian subjects (OR = 1.15, 95 % CI = 1.10–1.20) and in the population as a whole, but not in Chinese subjects.