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Patients with tumors of the upper and lower respiratory tract may experience acutely worsening airway compromise due to edema, bleeding, infection, or loss of protective mechanisms. Presenting symptoms and signs include dyspnea, tachypnea, wheezing and stridor. Imaging involves plain radiographs, CT scan, and/or endoscopic visualization. Emergency measures include supplemental humidified oxygen, maintenance of airway through optimal patient positioning, and, possibly, administration of a helium-oxygen mixture. If intubation is required, an "awake look" with a fiber optic bronchoscope with a 5-0 or 6-0 endotracheal tube is preferred. An emergency surgical airway, such as cricothyroidotomy, transtracheal jet ventilation, or tracheotomy may be needed. Consult with an oncologist or surgeon for definitive management.

Patient with solid tumors, most commonly breast, lung, and prostate, may present with pain, pathologic fracture, or spinal cord compression caused by bony metastases. Patients with spinal cord compression may also exhibit muscular weakness, radicular pain, and bowel or bladder dysfunction. Plain radiographs are obtained initially to assess for fracture or bony involvement, followed by CAT scan or MRI to further delineate lesions. Treatment priorities include pain control with opioid analgesia and restoration or salvage of function. Most pathologic fractures require surgical intervention. Painful bone metastases are treated with radiotherapy. The presentation, evaluation, and management of malignant spinal cord compromise are described in Table 139-1.