Why obese fathers tend to produce overweight daughters

A new study, conducted on mice, has shown that obese fathers tend to produce daughters that are heavier because of an epigenetically altered breast tissue.

The findings come from one of the first animal studies to examine the impact of paternal obesity on future generations' cancer risk.

In addition, the researchers say they've found evidence that obesity could change the microRNA (miRNA) signature - epigenetic regulators of gene expression - in both the dad's sperm and the daughter's breast tissue, suggesting that miRNAs may carry the epigenetic information from obese dads to their daughters.

The miRNAs identified are known to regulate insulin receptor signaling, which is linked to alterations in body weight and others molecular pathways that are associated with breast cancer development such as estrogen receptor signaling.

Obesity seems to sometimes run in families, as does some breast cancers.

Maternal obesity is believed to influence both conditions in humans - a woman who is heavy in pregnancy can produce larger babies, who may have increased risk of breast cancer later in life. But few if any studies have looked at the influence of dad's obesity on his offspring's cancer risk.

Study's lead investigator, Sonia de Assis, assistant professor in the Department of Oncology at Georgetown Lombardi, said that the study provides evidence that, in animals, a fathers' body weight at the time of conception affects both their daughters' body weight both at birth and in childhood and likely their risk of breast cancer later in life.

"Of course our study was done in mice, but it would be very interesting to know if the same associations hold for daughters of human fathers who were obese at the time of conception," she said.