Posters

Poster Details

First Author: R.Fayzrakhmanov RUSSIA

Co Author(s): M. Bikbov

Abstract Details

Purpose:

To study the dynamics of morphological and functional parameters of the central retina in patients with fibrovascular membrane in macular degeneration on the background of the use of angiogenesis blockers.

Increase in light sensitivity of the central retina from 1.22 ± 0.95 dB up to 3.97 ± 1.21 dB (p <0.05), visual acuity - from 0,08 ± 0,06 to 0,11 ± 0,05 with triple use of angiogenesis blockers were observed in the 1st group. After the first injection the indicators of fixation test changed on average from of ± 12.11o 4.62o to 6.24o ± 3.66o, in subsequent injections position of the fixation point remained practically unchanged and remained at this level. The height of the membrane decreased to 113.03 ± 42.17 µm, compared with the data prior to the therapy (141.76 ± 42.91 µm). Reduction of the membrane (p <0.05) was observed in some parts of the retina. The height of the photoreceptor layer was 63.44 ± 23.85 µm, statistically significant (p <0.05) different from the parameters before treatment (125.46 ± 36.11 µm). The thickness of the retina decreased to 228.84 ± 94.48 µm (before treatment - 443.24 ± 132.91 µm, p <0.05). Maximal effect of antivazoproliferativnoy therapy was observed after a single injection of anti-VEGF drugs. In the 2nd group stabilization of morphological and functional parameters of the central retina was noted after a single injection of the drug.

Conclusions:

Changes of morphological and functional parameters are registered during the entire treatment, which show the efficacy of antivasoproliferative therapy. The most significant change in the functional parameters of the macular zone occurs after the first course of therapy. On this basis, antivasoproliferative therapy is effective only in the case of a single intravitreal injection for active fibrovascular membrane.