Previous HGNC Symbols for BSG Gene

Previous GeneCards Identifiers for BSG Gene

Summaries for BSG Gene

Entrez Gene Summary for BSG Gene

The protein encoded by this gene is a plasma membrane protein that is important in spermatogenesis, embryo implantation, neural network formation, and tumor progression. The encoded protein is also a member of the immunoglobulin superfamily. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Products:

Protein details for BSG Gene (UniProtKB/Swiss-Prot)

Protein attributes for BSG Gene

Size:

385 amino acids

Molecular mass:

42200 Da

Quaternary structure:

Forms homooligomers in a cis-dependent manner on the plasma membrane. Forms heterooligomers of isoform 2 and isoform 3. Forms a complex with MMP1 at the tumor cell surface. Interacts with ATP1B2, MAG and L1CAM (By similarity). Interacts with AJAP1. Interacts with SLC16A1, SLC16A7 and SLC1A3; probably a BSG dimer is associated with a monocarboxylate transporter dimer. Interacts with PPIL2; regulates BSG transport to the cell membrane. Interacts with SLC16A11 (PubMed:28666119).

Localization for BSG Gene

Subcellular locations from UniProtKB/Swiss-Prot for BSG Gene

Cell membrane; Single-pass type I membrane protein. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. In spermatozoa, localized on the principal piece of caput and in the middle piece during transit in the corpus and cauda epididymides (By similarity). {ECO:0000250 UniProtKB:P18572, ECO:0000269 PubMed:17081065}.