GeneCards Summary for CABP1 Gene

CABP1 (Calcium Binding Protein 1) is a Protein Coding gene.
Diseases associated with CABP1 include Amebiasis.
Among its related pathways are Visual Cycle in Retinal Rods.
Gene Ontology (GO) annotations related to this gene include calcium ion binding and protein domain specific binding.
An important paralog of this gene is CABP2.

Protein details for CABP1 Gene (UniProtKB/Swiss-Prot)

Protein attributes for CABP1 Gene

Size:

370 amino acids

Molecular mass:

39838 Da

Quaternary structure:

Homodimer; when bound to calcium or magnesium. Interacts (via C-terminus) with ITPR1, ITPR2 and ITPR3. This binding is calcium dependent and the interaction correlates with calcium concentration. An additional calcium-independent interaction with the N-terminus of ITPR1 results in a decreased InsP(3) binding to the receptor. Interacts with CACNA1A (via C-terminal CDB motif) in the pre- and postsynaptic membranes. Interacts with CACNA1C (via C-terminal C and IQ motifs). The binding to the C motif is calcium independent whereas the binding to IQ requires the presence of calcium and is mutually exclusive with calmodulin binding. Interacts with CACNA1D (By similarity). Interacts with TRPC5 (via C-terminus). Interacts (via EF-hands 1 and 2) at microtubules with MAP1LC3B. Interacts with MYO1C (By similarity). Interacts (via EF-hands 1 and 2) with NSMF (via the central NLS-containing motif region), the interaction occurs in a calcium dependent manner after synaptic NMDA receptor stimulation and prevents nuclear import of NSMF. Interacts with SPACA9 (By similarity).

SOURCE GeneReport for Unigene cluster for CABP1 Gene:

mRNA Expression by UniProt/SwissProt for CABP1 Gene:

Tissue specificity:Retina and brain. Somatodendritic compartment of neurons. Calbrain was found exclusively in brain where it is abundant in the hippocampus, habenular area in the epithalamus and in the cerebellum.