young to middle age adults; phily chromosome present in over 95% of cases; bcr-abl is another way of diagnosing CML; fever with no infection, bone pain, LUQ pain due to enlarged spleen, fatigue, weakness, night sweats, bleeding and brushing, petechiae

A Thal trait: HgB electrophoresis shows no increase in HgB A2 or F, no HgB H; usually diagnosed via exclusion; Hgb H: peripheral smear abnormal, high retic count b/c hemolysis is occuring and body is trying to keep up with rate of destruction

loss of central pallor in RBCs; anemia usually microcytic and mild to moderate or absent (bone marrow is usually able to compensate); reticulocytosis is present; indirect bili may be elevated; Coombs test negative