GeneCards Summary for INTU Gene

UniProtKB/Swiss-Prot for INTU Gene

Plays a key role in ciliogenesis and embryonic development. Regulator of cilia formation by controlling the organization of the apical actin cytoskeleton and the positioning of the basal bodies at the apical cell surface, which in turn is essential for the normal orientation of elongating ciliary microtubules. Plays a key role in definition of cell polarity via its role in ciliogenesis but not via conversion extension. Has an indirect effect on hedgehog signaling (By similarity). Proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies (PubMed:27158779).

Protein details for INTU Gene (UniProtKB/Swiss-Prot)

Protein attributes for INTU Gene

Size:

942 amino acids

Molecular mass:

105648 Da

Quaternary structure:

Interacts with C5orf42/JBTS17. Interacts with FUZ and WDPCP; FUZ, INTU and WDPCP probably form the core CPLANE (ciliogenesis and planar polarity effectors) complex (By similarity). Interacts with NPHP4 and DAAM1; INTU is mediating the interaction between NPHP4 and DAAM1 (PubMed:26644512).

Function for INTU Gene

Products:

Molecular function for INTU Gene

UniProtKB/Swiss-Prot Function:

Plays a key role in ciliogenesis and embryonic development. Regulator of cilia formation by controlling the organization of the apical actin cytoskeleton and the positioning of the basal bodies at the apical cell surface, which in turn is essential for the normal orientation of elongating ciliary microtubules. Plays a key role in definition of cell polarity via its role in ciliogenesis but not via conversion extension. Has an indirect effect on hedgehog signaling (By similarity). Proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies (PubMed:27158779).

No data available for
Polymorphic Variants from UniProtKB/Swiss-Prot
for INTU Gene

Disorders for INTU Gene

Relevant External Links for INTU

No data available for
MalaCards ,
UniProtKB/Swiss-Prot and
Genatlas
for INTU Gene

Publications for INTU Gene

Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.(PMID: 10574462)Nagase T … Ohara O(DNA research : an international journal for rapid publication of reports on genes and genomes 1999)23460

PCP effector proteins inturned and fuzzy play nonredundant roles in the patterning but not convergent extension of mammalian neural tube.(PMID: 21761479)Heydeck W … Liu A(Developmental dynamics : an official publication of the American Association of Anatomists 2011)2360