To avoid the traffic in Jacksonville, take the first exit off I-95 in Fl for route 200. This leads directly into 301 south with good signage and good roads. There's a good overnight campground at the last exit in Kingsland Georgia - KIKI park. Not fancy, but very close to I-95. There's a KOA in Starke, Fl right on 301 about 3 hours north of Tampa.

x2 what wbdavey said; US301 the way to go to just north of Ocala. Take 326 west to I-75 then south to Tampa. 301 a little iffy from Ocala south.

Absolutely! We live just north of here. Avoid 301 through Ocala unless you are avoiding I-75 due to a traffic tie-up or if you just want to visit. Rt. 326 is a good place to gain entrance to the interstate and there is a truck stop (or two) there where you can gas up if needed. Where are you staing in Tampa? Have a safe trip!

I live just off I-75 north of Tampa. Thanks for the information. I am familiar with the Jacksonville area but had forgotten the drive around to miss Jacksonville. We usually do the Ohio, Kentucky, Tenn, Alabama route to Pennsacola to visit grandchildren. Thanks for the info.