Upcoming game for Xbox 360, PS3 and PC. Release for June-July '09.
You play as a shape-shifter with no knowledge of your past and must fight your way through New York City to recover your previous life.

The game is open-worlded, like GTA IV, Assasin's Creed and Halo 3: ODST all roled into one.

Guy 1: So yeah, we good to go on Saturday?
Guy 2: Have you heard about Prototype? It looks so damn awesome!
Guy 1: OMFG Yeah! *orgasm*