Ten years ago, avoidance measures such as the performance of latex- free
operations were implemented in children with spina bifida. Since then, latex
sensitization and latex allergy have decreased in this high-risk group. We
studied the effect of primary latex-free prophylaxis on the prevalence of
allergic diseases and atopy. We discussed sensitization spreading as a cause
for elevated prevalence of atopy and allergy in children with spina bifida.