Morphine following common childhood surgery may be life threatening

TORONTO – Treating post-operative pain with morphine can cause life-threatening respiratory problems in some children who have had their tonsils and/or adenoids removed, new research has found.

The study, co-conducted by the Motherisk Program at The Hospital for Sick Children (SickKids) and by McMaster University and McMaster Children’s Hospital, has identified a significant risk for potentially-fatal breathing disruption when morphine is administered at home after surgery to treat pain in children who undergo tonsillectomy with or without adenoidectomy. This surgery is commonly and effectively used to treat childhood sleep apnea. The study also showed ibuprofen is a safe and effective alternative. The study is published in the Jan. 26 online edition of PEDIATRICS.

The research builds on a 2009 Motherisk study and a 2012 study by the two groups that found codeine administered for post-operative pain in the same population of children could cause respiratory problems and fatal outcomes for children who are genetically ultra-rapid metabolizers of codeine. Previously, codeine had been the standard treatment for post-operative pain in this population across North America.

As a result of the 2009 paper, both Health Canada and the U.S. Food and Drug Administration (FDA) issued warnings about the risks associated with giving codeine to this population of children. The FDA gave paediatric codeine a “Boxed Warning” – its strongest warning – as well as a contraindication. While no official recommendation of a safe and effective alternative had been made in response to these warnings, many centres prescribed morphine to these children believing that the response to the drug would be more predictable.

This new study is a prospective, randomized clinical trial in which 91 children between the ages of one and 10 were randomly assigned to receive post-operative painkillers at home following their outpatient tonsillectomy surgery to treat obstructive sleep apnea. Parents were given a prescription to fill and were instructed about the use of a home pulse oximeter to measure oxygen saturation and apnea events (pauses in breathing) the night before and the night after surgery. Parents were also taught to use the Objective Pain Scale and Faces Scale to assess their children’s pain levels on post-operative days one and five.

From September 2012 to January 2014, one group of children was given post-operative standard doses of oral morphine (0.2 to 0.5 mg/kg) and acetaminophen (10-15 mg/kg) every four hours to treat their pain, while the other group was prescribed standard doses of oral ibuprofen (10 mg/kg) every six hours and acetaminophen (10-15 mg/kg) every four hours. Pain was effectively managed and comparable in both groups. On the first post-operative night, 68 per cent of children in the ibuprofen group showed improvement in oxygen desaturation incidents (a drop in oxygen concentration in the blood). On the same night, only 14 per cent of children in the morphine group improved. In fact, in the short term, the condition of these children worsened, with substantially more desaturation events in the morphine group – roughly 11 to 15 events per hour. Both groups had similar minimal levels of other adverse drug reactions and bleeding.

Last year, midway through the planned study period, an interim analysis was conducted by the study’s Drug Safety Monitoring Board. In addition to the general findings, which strongly demonstrated serious respiratory risk associated with morphine, one child suffered a life-threatening adverse drug reaction including oxygen desaturation after being treated with morphine. These severe outcomes prompted the Board to halt the study period early and the research team notified both hospitals’ Research Ethics Boards.

“The evidence here clearly suggests children with obstructive sleep apnea should not be given morphine for post-operative pain. We already know that they should not get codeine either,” says Dr. Gideon Koren, corresponding author of the study, Founding Director of the Motherisk Program and Senior Scientist at SickKids. “The good news is that we now have evidence that indicates ibuprofen is safe for these kids, and is just as effective in controlling their pain, so there’s a good alternative available for clinicians to prescribe.”

Clinicians should re-think the routine use of morphine for post-operative pain in children with sleep apnea, says study co-author Dr. Doron Sommer, a clinical professor of surgery at McMaster’s Michael G. DeGroote School of Medicine and a surgeon for McMaster Children’s Hospital.

“These results should prompt clinicians to re-evaluate their post-tonsillectomy pain treatment regimen. Due to the unpredictable respiratory side-effects of morphine, its use as a first-line treatment with current dosage ranges should be discontinued for outpatient tonsillectomy,” says Sommer.

At both SickKids and McMaster Children’s Hospital, the use of morphine for post-operative pain from paediatric tonsillectomy is reserved for exceptional cases where it is deemed necessary and safe with appropriate monitoring.

Tonsillectomy is among the most common paediatric surgical procedures. In Ontario, about 14,000 tonsillectomies are performed each year.

Koren is also Professor of Paediatrics, Pharmacology and Toxicology, Pharmacy and Molecular Genetics at the University of Toronto.

The research is supported by the Drug Safety and Effectiveness Network of the Canadian Institutes of Health Research, and SickKids Foundation.

About The Hospital for Sick Children

The Hospital for Sick Children (SickKids) is recognized as one of the world’s foremost paediatric health-care institutions and is Canada’s leading centre dedicated to advancing children’s health through the integration of patient care, research and education. Founded in 1875 and affiliated with the University of Toronto, SickKids is one of Canada’s most research-intensive hospitals and has generated discoveries that have helped children globally. Its mission is to provide the best in complex and specialized family-centred care; pioneer scientific and clinical advancements; share expertise; foster an academic environment that nurtures health-care professionals; and champion an accessible, comprehensive and sustainable child health system. SickKids is proud of its vision for Healthier Children. A Better World. For more information, please visit www.sickkids.ca.

About McMaster University and the Michael G. DeGroote School of Medicine

McMaster University, one of four Canadian universities listed among the Top 100 universities in the world, is renowned for its innovation in both learning and discovery. It has a student population of 23,000, and more than 160,000 alumni in 140 countries. The Michael G. DeGroote School of Medicine is internationally renowned for its pioneering of problem-based, small group learning, as well as its world class medical and health science research.

About McMaster Children’s Hospital

McMaster Children’s Hospital is a leading Canadian pediatric hospital, serving a region of 2.3 million people in the south-central Ontario area surrounding Hamilton. As one of the fastest growing pediatric centres in Canada, it is the regional provider for a broad range of services including children’s emergency care and trauma, the lead for child and youth mental health services, and has Ontario’s largest neonatal intensive care unit. It provides compassionate, family-centred care by dedicated pediatric specialists. As part of Hamilton Health Sciences, and affiliated with McMaster University, it combines clinical care with research and teaching to ensure innovation. McMaster Children’s Hospital is dedicated to Caring for our future.