Java Adaptive Mathematical Modeling Engine (JAMME) is a proposal for collaboration between the UW Bioengineering JSIM Project and the UW Cell Systems Initiative's Cellworks Project. The collaboration would take the form of continued development of the adaptive (mathematically directed) modeling engine JSIM by integrating its components with the Moulage System framework, the Metagraph data representation model, and the new object database systems currently under development. The new engine would be capable of providing dynamic real time cellular and biological modeling in a mathematically and visually adaptive environment for biological researchers.