The storyline focuses on Makino Tsukushi's choice between F4 Leader Doumyouji Tsukasa and F4 member Hanazawa Rui. F4 stands for Flower 4, four close rich friends, the power clique that rules Eitoku University.

Makino Tsukushi is the only poor student at Eitoku Gakuen, the school of the ridiculously rich and privileged that is ruled by Flower 4 or F4, a group of four boys who come from extremely powerful families: Domyoji Tsukasa, the leader and heir of the Domyoji World Finance Group; Hanazawa Rui, the introverted son of a large company; Nishikado Sojiro, a player who is the heir of a tea ceremony school; and Mimasaka Akira, a madam killer with ties to the underground. If a student gets on the F4’s bad side, he/she gets a red notice and is bullied and driven out of school.

Makino hopes to pass her days quietly-- without drawing any attention to herself-- but one day, she stands up to Domyoji in defense of her friend. The next day, Makino gets the dreaded red notice. Even though she is harassed, Makino decides to keep going to school because she is a "tough weed". She declares war right back on the F4. Her resolve gets the attention of her crush Hanazawa Rui and oddly enough, rouses romantic feelings in her worst enemy, Domyoji Tsukasa.

Cast

Inoue Mao as Makino Tsukushi

Matsumoto Jun as Domyoji Tsukasa

Oguri Shun as Hanazawa Rui

Matsuda Shota as Nishikado Sojiro

Abe Tsuyoshi as Mimasaka Akira

Sato Megumi as Sanjo Sakurako

Nishihara Aki as Matsuoka Yuki

Seto Saki as Asai Yuriko

Fukada Aki as Ayuhara Erika

Matsuoka Emiko as Yamano Minako

David Ito as Nishida

Sada Mayumi as Todo Shizuka

Kato Takako as Sengoku Sachiyo

Tomiura Satoshi as Makino Susumu (brother of Tsukushi)

Kobayashi Susumu as Makino Haruo (father of Tsukushi)

Ishino Mako as Makino Chieko (mother of Tsukushi)

Matsushima Nanako as Domyoji Tsubaki (sister of Tsukasa)

Kaga Mariko as Domyoji Kaede (mother of Tsukasa)

Guests

Ito Kazue as Yamanaka Minako

Nakayama Masei as Terada Junji (Class 2C)

Ikeda Kaori as Morioka Mizuki

Kaku Tomohiro as Sawatari Shingo (ep1)

Sano Kazuma as Kimoto Takayuki (ep1)

Hasegawa Tomoharu (ep1)

Igarashi Shunji (ep1)

Handa Kento as Ryuji (ep4-5)

Gashuin Tatsuya (ep4-5)

Takuma Takayuki (ep4-9)

Oshinari Shugo as Nakatsuka (ep6-7)

Mitsuya Yoko as Nakatsuka's other girl (ep6-7)

Sakai Ayana as Kurimaki Ayano (ep8-9)

Hankai Kazuaki as TOJ's emcee (ep8-9)

Shibuya Momoko as a TOJ participant (ep8-9)

Suzuki Sotaro (ep9)

Season 2

Episodes: 11

Broadcast period: 2007, January 05 to 2007, March 16

Theme song: Love So Sweet by Arashi

Insert song: Flavor of Life by Utada Hikaru

Synopsis

This second season of Hana Yori Dango picks up right after Domyoji leaves for New York. After confessing to Domyoji, Makino has not spoken to him for a year. Rui and the other members of F4 try and help Makino meet Domyoji again by going to New York for the christmas holidays. Though F4 and Makino meet Domyoji again, he has become a completely different person, and so they leave for Japan.

Some time later, Domyoji's mother annouces that they will be returning to Japan. There, they hold a giant super-rich and classy birthday party for Domyoji and announce something very important. Domyoji, like in the first season, is engaged to a rich girl and heir. The only difference is that they are to be wed soon. What will Makino do?

On the side, Rui begins to fall in love with Makino... will this become a love... square?

The Makinos take New York in this special Hana Yori Dango spin-off. Worried about Tsukushi (Inoue Mao) going to New York by herself to look for Tsukasa (Matsumoto Jun), the Makino parents also head to the Big Apple for their first family vacation. Traveling on a tight budget, the bumbling family of three eat and visit the best of New York spending as little money as possible and creating some funny adventures along the way.

Cast

Inoue Mao as Makino Tsukushi

Matsumoto Jun as Domyoji Tsukasa

Oguri Shun as Hanazawa Rui

Matsuda Shota as Nishikado Sojiro

Abe Tsuyoshi as Mimasaka Akira

Tomiura Satoshi as Makino Susumu

Kobayashi Susumu as Makino Haruo

Ishino Mako as Makino Chieko

Movie 2

Title: 花より男子～ファイナル～ / 花より男子ファイナル

Title (romaji): Hana yori dango: Fainaru

Also known as: Boys Over Flowers: Final

Release Date: 2008, June 28

Synopsis

High school sweethearts Tsukasa and Tsukusi are finally getting married. Tsukasa gives his fiancee a precious family heirloom ― but only to see a robber disappear with it. Tsukasa and three other F4 friends reunite for the globetrotting search.