41-50 on our diverse list of individuals, couples and families changing the world, for good and ill.

41. David Ray Griffin

Top truther

Conspiracy theories are everywhere, and they always have been. In recent years, one of the most pernicious global myths has been that the US government carried out, or at least colluded in, the 11 September 2001 attacks as a pretext for going to war. David Ray Griffin, a retired professor of religion, is the high priest of the "truther" movement. His books on the subject have lent a sheen of respectability that appeals to people at the highest levels of government - from Michael Meacher MP to Anthony "Van" Jones, who was recently forced to resign as Barack Obama's "green jobs" adviser after it emerged that he had signed a 9/11 truth petition in 2004.

42. Shahrukh Khan

Special K

For billions of people across Asia, Shahrukh Khan is the biggest star on earth. Since his film debut in 1992, King Khan has been the ruling monarch of Bollywood, the world's largest film industry. "I want people to scream and shout at me," he says. Which is lucky, as he is wildly popular in India, Pakistan and even Afghanistan, where his films were sold on the black market during Taliban rule. A Muslim hero in a Hindu nation, SRK, as he is affectionately known, is the symbol of a younger, confident, richer, globalised India.

43. Joaquín "Shorty" Guzmán

Cocaine knight

At a diminutive 5ft, Mexico's most wanted man is nicknamed "El Chapo" (Shorty). But don't let that fool you - as the top drug lord in a country that provides 90 per cent of all cocaine in the US, Guzmán is instrumental to the international drugs trade and the thousands of lives it claims each year. Head of the Sinaloa cartel, he escaped from prison in 2001 and has since eluded capture. His stake in the US drugs market has amassed him a fortune of $1bn, earning him a place on the Forbes rich list this year.

44. Hugo Chávez

Bolívar's boy

Since being elected president of Venezuela in 1998, Hugo Chávez, the standard-bearer of "21st-century socialism", has survived all attempts to unseat him and has vowed to continue leading the Bolivarian revolution until 2030. His victory earlier this year in a referendum to abolish term limits allows him to run for a third six-year term in 2013. The former army paratrooper's political philosophy, a fusion of Marxism, nationalism and Christian socialism, has inspired left-wing leaders across Latin America - and dismayed US politicians.

45. Peter Akinola

Unhappy clapper

As head of the Church of Nigeria, Akinola is one of the most controversial figures in the worldwide Anglican Communion. He campaigned in 2003 against the consecration of two gay men: Jeffrey John in Reading and Gene Robinson in New Hampshire. The Church of England backed down on John's appointment and a schism was avoided - just. In 2006, at Akinola's invitation, two disenchanted congregations in the US placed themselves under the authority of the Church of Nigeria. And last year's Lambeth Conference was boycotted by 250 traditionalists. Africa is the fastest-growing section of the Church, and Akinola's influence is sure to extend beyond his retirement in March 2010.

46. Anna Wintour

Atomic kitter

Her nickname, "Nuclear Wintour", says it all. The editor of American Vogue is the ultimate ice queen. Both films made about her - one fictional (The Devil Wears Prada) and the other a documentary (The September Issue) - depict her as a terrifying, dictator-like figure, able to shape fashion the world over, from the top designers to the high street chains. But fashion is never just fashion. Wintour's editorial eye will determine what we buy and what we see from one year to the next.

47. Jay-Z and Beyoncé

Pop idols

Beyoncé walks onstage in an explosion of lights and glitter and sequin leotards, and the 20,000-strong crowd bursts into a frenzy of excitement. When she sings "Ave Maria", the arena is hushed. But it's not simply her performance, or her charisma. The woman is a machine. She is somewhere beyond sweaty human reality. Her force and energy seem superhuman. There isn't a lapse, a misstep, not even a glimpse of uncertainty.

Beyoncé is a workaholic. Just as she conquers one thing, she seeks out another and beats that into submission, too. Destiny's Child seems an age ago, after "Crazy in Love", Dreamgirls and her Sasha Fierce incarnation. She has sold over 75 million records, spent more weeks at number one than any other female artist this decade and earned nearly $90m last year, making her the highest-paid entertainer under 30. She has also launched the inevitable fashion line, House of Deréon. She sang for the Obamas; she visits hospitals and rehabilitation centres; she encourages her fans to bring groceries to her US concerts to help feed America. Beyoncé is fast becoming a saint, with the power to convince millions of her cause.

As if Beyoncé weren't enough on her own, she became one half of arguably the most powerful showbiz couple in the world when she married Jay-Z in April 2008.

Jay-Z is a rapper by trade, but by founding Roc-A-Fella Records, running Def Jam and then starting Roc Nation, he has become a vastly influential music industry boss, launching the careers of Ne-Yo and Rihanna along the way. He, too, has a fashion label, Rocawear; and he owns the New Jersey Nets basketball team and invests in smart New York hotels. Together, Beyoncé and Jay-Z preside over an expanding empire. But it's about more than wealth, or power. They have a steeliness about them. They do not make mistakes. There is a feeling that they have somehow gone beyond the foibles of being human to a place where perfection is effortlessly within their control.Sophie Elmhirst

48. Jóhanna Sigurdardóttir

Ice queen

Has Iceland ever made more headlines than in the past year? Still reeling from the banking collapse of last October, the country has started on the road to recovery with one giant step for womankind. In February, Sigurdardóttir - Iceland's only minister to have gained in popularity in 2008 - became not only the country's first female prime minister, but the world's first openly gay leader. After losing a bid to lead the Social Democrats in 1994, Saint Jóhanna (as Sigurdardóttir has been nicknamed) declared: "My time will come." That time is now.

49. Patricia Woertz

Grain goddess

As CEO of Archer Daniels Midlands (ADM), one of the largest food processors in the US, Patricia Woertz's influence in corn, wheat and soybean production extends across the world. She has been the driving force behind the conglomerate's switch from food to bio-energy, pushing ADM's investment in corn ethanol production and profiting from heavy government subsidies designed to "help the American farmer". ADM brandishes the slogan "Resourceful by Nature", yet it still ranks as the tenth worst polluter in the US.

50. Dan Brown

Conspiracy theorist

Love or hate him, Dan Brown is one of the bestselling authors of all time. The Da Vinci Code, a thriller about a conspiracy to conceal the marriage and modern-day descendants of Jesus Christ and Mary Magdalene, has sold 80 million copies and been translated into 44 languages. Its success triggered a deluge of similar novels, guides to the theories, and books refuting its claims - not to mention a huge spike in tourism to the places it featured. His latest novel, The Lost Symbol, which focuses on freemasonry and the Founding Fathers, has smashed first-day sales records. Watch this space for a mass exodus of conspiracy tourists to Washington, DC.