The college football Week 6 picks are in, and Sporting News’ Matt Hayes and Steve Greenberg offer their predictions for this Saturday’s biggest Top 25 games. This week's schedule is without question the year's best thus far, with No. 4 LSU facing No. 10 Florida in the Swamp, No. 5 Georgia hosting No. 6 South Carolina, and No. 8 West Virginia heading to Austin to face No. 11 Texas.

Hayes (39-11; 7-3 last week): Oregon 42, Washington 21. I mean, I guess I get all the Ducks love because they’re fast and they’ve got great unis. But really, who has Oregon played and what have they done for anyone to think, yeah, this is an elite team? Please don’t give me Arizona, or I’ll puke.

Greenberg (39-11; 7-3 last week): Oregon 37, Washington 24. “Elite” is one of those words that tends to be used cheaply by the sports media, but the Ducks are in the tiny handful of programs that warrant it. Deep down, even Mr. SEC Blinders knows that.

Greenberg: FSU 41, NC State 31. It’ll get hot under the collar for the ’Noles, but they’ve got too many playmakers not to exploit a terrible Wolfpack defense. I’m really starting to feel this unbeaten-regular-season thing.

Hayes: FSU 34, NC State 24. Why is it every time I watch NC State in a game of significance, the Wolfpack are losing? Every time they’re playing a meaningless ACC game, they’re winning and eventually find a way to eight wins.

Greenberg: Florida 20, LSU 17. Until the very moment that I typed that score, I’d assumed I’d be picking the Tigers. But you know what? They just don’t deserve it. Maybe this team of Les Miles’ just doesn’t have the drive and focus it needs to win a national title; that happens sometimes. The Gators, meanwhile, have improved every time out and aren’t playing with an ounce of fear or trepidation.

Hayes: LSU 23, Florida 16. Here’s the baseline problem at LSU (other than a poor noncon schedule): the Tigers don’t have a Tyrann Mathieu leader type—an emotional guy who gets the team juiced and ready to play a big game. It’s time for DE Sam Montgomery to make it happen as a leader and a pass rusher in this very game.

Hayes: South Carolina 30, Georgia 28. These teams are so close, with so much similarity, I have to go with the one thing that separates them: South Carolina’s mobile quarterback (Connor Shaw) can avoid a rush better than Georgia’s pocket passer (Aaron Murray).

Greenberg: Georgia 26, South Carolina 24. The Bulldogs are genuinely balanced on offense like they haven’t been since 2005, their last SEC championship season. If their defense shows up determined to win in Columbia—and it better—then Connor Shaw shouldn’t be able to run all day without taking some hellacious shots.

Hayes: Texas 38, West Virginia 28. I don’t care how good Geno Smith has looked since last year’s Orange Bowl, he hasn’t played a defense that can rush the passer since prior to that game. Texas can—the Longhorns can keep Smith off the field by pounding away with a power run game.

Greenberg: Texas 52, West Virginia 45. This is just what the Big 12 is; even defenses with a bunch of future NFL players get ripped and rolled. Time for Geno to throw his first couple of picks, though, and that’ll be the difference.

Greenberg: Notre Dame 38, Miami 17. The Canes have some legit playmakers in the passing game, but the Irish’s ability to pressure the passer and create turnovers is a bigger deal. And this is the game when ND really flexes its muscle with its run game.

Greenberg: Ohio State 27, Nebraska 24. Boy, how long has it been now since a Bo Pelini team has played 60 minutes of good ball vs. a really good team? Funny thing is, I have a feeling this’ll be a night when the Huskers show up in a big way and lose anyway. There’s no evidence to suggest the Huskers’ D can rein in Braxton Miller.

Hayes: Ohio State 23, Nebraska 17. I’m not sure there’s evidence to suggest any Big Ten defense can rein in Miller. If Michigan State didn’t slow down Miller after 20-plus carries, what makes anyone think Nebraska—which hasn’t played good defense since the Ndamukong Suh years—will?

Hayes: Oklahoma 27, Texas Tech 17. I’ve got this strange feeling that OU’s implosion against K-State wasn’t an anomaly. The Sooners have had two weeks to prepare for a team that embarrassed them last year in Norman.

Greenberg: Oklahoma 49, Texas Tech 14. It wasn’t an “implosion,” really; it was a slightly overrated team losing to an obviously underrated one. The Sooners are always good for a few outings per season when they look darned near unbeatable, though, and this is going to be one of them. Yep, the revenge factor is for real here.

Greenberg: Northwestern 23, Penn State 21. Pat Fitzgerald has gone oh-fer vs. PSU since he took over in Evanston in 2006. It’s time for that to end. The Nits have shown a lot of late-game toughness since starting 0-2, but the 5-0 Wildcats have been tough as nails down the stretch of games. Streak-buster, baby.

Hayes: Penn State 23, Northwestern 21. It’s a great story line and we all love the underdog. But Northwestern hasn’t played a defense like Penn State’s, and will have to wait until the NCAA sanctions impact Penn State in the next couple of years before snapping that streak.