An air strike on a busy market area in Yemen that reportedly killed scores of people including more than 20 children on a bus, is likely the worst attack on youngsters in the conflict so far, and the latest in a recent spate of violence targeting civilians, UN agencies said on Friday.

According to the UN Human Rights Office, OHCHR, and UN Children's Fund, UNICEF, at least 21 boys � most of them under the age of 15 � died when their bus was hit on Thursday in Dahyan market in Saada, in the north of the country.

More than 30 boys were also injured in the aerial bombardment, which was carried out by a Saudi-led international coalition that has backed Yemen President Abd Rabbu Mansour Hadi against Houthi opposition forces for more than three years.

The UN Special Envoy for Yemen, Martin Griffiths, said that he was deeply shocked by the appalling tragedy that claimed so many innocent lives. The UN official has invited the warring parties to Geneva on 6 September in a bid to reach a political solution to the conflict � the first such discussions since 2016.

This should urge us all to exert more efforts to end the conflict through an inclusive intra-Yemeni dialogue, he added, stressing that he hoped all of those involved in the fighting across the country will engage constructively in the political process, including consultations scheduled in Geneva in September.

Briefing journalists in Geneva on Friday, UNICEF spokesperson Christophe Boulierac said that the agency believed the air strike on the school bus constituted the single worst attack on children since 2015. No such number of children have been involved in one incident before, he added. Mr. Boulierac explained that following the attack, UNICEF staff on the ground reported chaotic scenes at the hospital where victims were being treated, adding that the number of fatalities could rise.

Reiterating the UN chief's call for Yemen's belligerents to spare civilians, OHCHR spokesperson Liz Throssell noted that the bus attack followed a series of more minor � but deadly - incidents involving youngsters last month.

A large number of children were killed yesterday appallingly, but in July, there are all manner of smaller incidents, she said. On 19 July, there were four children killed when a coalition air strike struck a farm. On 30 July, two children were killed when an air strike hit a motorbike. On 31 July, two children were killed; they were out with their sheep, grazing, and they took a direct hit from an aerial strike.

Turning to the recent targeting of a hospital and other targets in the key Houthi-controlled port city of Hudaydah, the OHCHR spokesperson said that staff there had documented at least 41 civilian deaths. Among the dead were six children and four women, Ms. Throssell said, noting that mortars had struck different built-up locations in Al Hawak district.

These included the fishing port, a dock and hangar at the time full of fishermen and street vendors, the OHCHR spokesperson explained, adding that Al-Thawra hospital was hit shortly afterwards. In that attack, three mortars were fired, including one that landed in a busy street full of traffic, street vendors and pedestrians, Ms. Throssell said.

Between 26 March and 9 August 2018, OHCHR has documented 17,062 civilian casualties in Yemen; this includes 6,592 dead and 10,470 injured. The majority of these casualties � 10,471 � were as a result of air strikes carried out by the Saudi-led Coalition, it said in a statement.

Amid ongoing conflict in one of the world's poorest countries, UNICEF warned that the consequences for children have been particularly striking.

Every day in Yemen, children are starving, children are dying because of the level of violence and its consequences, spokesperson Christophe Boulierac said. 1.8 million children are at risk of diarrhoeal diseases, 1.3 million children are at risk of pneumonia, more than 4 million children are in acute need of educational assistance. So, any violence in Yemen, any facility that provides water indirectly threatens the lives of children.

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