Palk strait estuarine water was highly polluted by Cu, Fe, Pb, Zn and Hg. The study was carryout
the interactions between heavy metals and microorganisms. The study area paying attention on the role of
probiotic bacteria such as Bacillus cereus, Aeromonas hydrophila, Pseudomonas aeruginosa, Azotobacter
vinelandii, and Lactobacillus sp. to remove the metals from polluted nine aquaculture ponds through the way
of bioremediation, bioaccumulation and mineralization process. The highest inhibition zone was absorbed in
Pseudomonas aeruginosa against Hg (3.796 mm) and Cu (0.060 mm), Aeromonas hydrophila against Pb (5.526
mm) and Bacillus cereus against Zn (4.504 mm) and Fe (1.635 mm). No inhibition zone was produced by
Azotobacter beijerinckii and control also maintained.