Endpoint summary

Administrative data

Description of key information

Skin sensitization:

The skin sensitization study for the target chemical Prussian blue was not available. Thus on the basis of available studies for the strcturally similar read across substances , Tetrasodium hexacyanoferrate (13601-19-9) and Ammonium Iron(3+) Hexakis(Cyano-C)Ferrate(4-) (25869-00-5) and applying the weight of evidence approach Prussian blue can be considered not irritating to skin and can be classified under the category “Not classified” as per CLP regulation.

The weight of evidence report has been prepared based on the read across substances identified based on strutural and functional similarity to assess the dermal sensitization potential of Prussian Blue

The study is based on weight of eveiance approach from the read across values

Challenge controls:

no data available

Positive control substance(s):

not specified

Other effects / acceptance of results:

no data available

Reading:

1st reading

Group:

test group

Clinical observations:

no dermal reactions observed

Remarks on result:

no indication of skin sensitisation

Interpretation of results:

other: not sensitizing

Conclusions:

On the basis of available studies for the functionally similar read across substances, the weight of evidence approach is applied to assess the skin sensitization potential for target substance. Prussian blue was estimated to be not sensitizing to guinea pig skin.

Executive summary:

On the basis of available studies for the functionally similar read across substances , Tetrasodium hexacyanoferrate (13601-19-9) and Ammonium Iron(3+) Hexakis(Cyano-C)Ferrate(4-) (25869-00-5) the weight of evidence approach is applied to assess the skin sensitization potential for Prussian blue[CAS: 14038 -43 -8].

Tetrasodium hexacyanoferrate was applied on the skin of guinea pig and it did not produce any allergic dermal reactions . Hence Tetrasodium hexacyanoferrate was considered to be not sensitizing to guinea pig skin.

The above experimental data was further supported by experimental study summarized in IUCLID Dataset of functionally similar read across substance Ammonium Iron(3+) Hexakis(Cyano-C)Ferrate(4-) (25869-00-5) available at European Chemicals Bureau (ECB) .

Ammonium iron(3+) hexakis(cyano–C)ferrate(4–) was applied on guinea pig skin in concentration 30% in water for induction and challenge treatment.

No skin sensitization reaction was observed. Hence, Ammonium iron(3+) hexakis(cyano–C)ferrate(4–) was considered as not sensitizing to guinea pig skin.

Based on the available data for the functionally similar read across substances and applying the weight of evidence approach, it can be concluded that Prussian blue will also be have in similar manner that of the read across substances and was estimated to be not sensitizing to skin. Thus it can be further classified under the category “Not Classified” as per CLP regulation.

Endpoint conclusion

Endpoint conclusion:

no adverse effect observed (not sensitising)

Additional information:

Skin Sensitization:

On the basis of available studies for the functionally similar read across substances , Tetrasodium hexacyanoferrate (13601-19-9) and Ammonium Iron(3+) Hexakis(Cyano-C)Ferrate(4-) (25869-00-5) the weight of evidence approach is applied to assess the skin sensitization potential for Prussian blue[CAS: 14038 -43 -8].

Tetrasodium hexacyanoferrate was applied on the skin of guinea pig and it did not produce any allergic dermal reactions . Hence Tetrasodium hexacyanoferrate was considered to be not sensitizing to guinea pig skin.

The above experimental data was further supported by experimental study summarized in IUCLID Dataset of functionally similar read across substance Ammonium Iron(3+) Hexakis(Cyano-C)Ferrate(4-) (25869-00-5) available at European Chemicals Bureau (ECB) .

Ammonium iron(3+) hexakis(cyano–C)ferrate(4–) was applied on guinea pig skin in concentration 30% in water for induction and challenge treatment.

No skin sensitization reaction was observed. Hence, Ammonium iron(3+) hexakis(cyano–C)ferrate(4–) was considered as not sensitizing to guinea pig skin.

Based on the available data for the functionally similar read across substances and applying the weight of evidence approach, it can be concluded that Prussian blue will also behave in similar manner that of the read across substances and was estimated to be not sensitizing to skin. Thus it can be further classified under the category “Not Classified” as per CLP regulation.

Respiratory sensitisation

Endpoint conclusion

Endpoint conclusion:

no study available

Justification for classification or non-classification

Based on the available data for the functionally similarread across substances;and applying the weight of evidence approach, it can be concluded that Prussian blue was not sensitizing to skin. It can be classified under the category “Not Classified” as per CLP regulation.

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