Abstract

Gold nanoparticles functionalized with antibodies can specifically bind to
molecular biomarkers such as epithelial growth factor receptor (EGFR). The
molecule specific nature of the antibody-functionalized gold nanoparticles forms
the basis for the developed optoacoustic imaging technique to detect cancer at
an asymptotic stage. Optoacoustic imaging was performed with 532 nm and 680 nm
pulsed laser irradiation on three-dimensional tissue phantoms prepared using a
human keratinocyte cell line. The results of our study demonstrate that the
combination of anti-EGFR gold bioconjugates and optoacoustic imaging can allow
highly sensitive and selective detection of human epithelial cancer cells.

Cited By

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.