Figure 7.

The infarct volume in rats exposed to ischemia–reperfusion injury by MCAO receiving
different doses of E2. (A) The OVX group resulted in larger infarct volume compared to the control group. 6
μg/kg and 20 μg/kg E2 replacement significantly decreased the infarct volume. 50 μg/kg
E2 replacement group resulted in larger infarct volume than the control group and
6 μg/kg or 20 μg/kg E2 replacement group. (**p < 0.01 v.s. the control group, #p < 0.05 v.s. the OVX group, *p < 0.05 v.s. the control group and 6 μg/kg or 20 μg/kg E2 replacement group). (B) Representative photographs showing infarct volume in the different groups after the
MACO.