Pharmacological action biltricid

Biltricid of instruction is anthelmintic drug that enhances the permeability of cell membranes for calcium ions helminths. This, in turn, stimulates the generalized reduction in parasites and muscle glucose uptake by cells stops worms. While applying biltricid reduces glycogen and promotes release of the compounds of lactic acid, leading to the death of the parasite. Praziquantel specifically active against cestodes and trematodes.

Indications biltricid

According to the instructions biltricid indicated for the treatment of infections caused by all sorts of species of schistosome (Schistosoma mekongi, Schistosoma intercalatum, Schistosoma haematobium, Schistosoma japonicum, Schistosoma mansoni), and also due to liver fluke (Opistorchis viverrini, Clonorchis sinensis) and lung fluke (Paragonimus westermani).

Contraindications

Application biltricid contraindicated in the following cases:

Hypersensitivity to the main or auxiliary components of the drug;

Children under four years;

In combination with rifampicin;

Cysticercosis eyes.

In the opinion of biltricid should be used with caution in cardiac arrhythmias, gepatolienalny schistosomiasis, decompensated liver failure.

Dosing and dosing regimen biltricid

According to the instructions biltricid intended for ingestion. Tablets are taken as a whole, without chewing, with some water. Exercise should be receiving shortly before or directly during a meal. If the recommended dosage is 1 tablet biltricid a day, it is best to take it in the evening. If the application is biltricid repeated during the day, then the dosing interval must be observed tablets 4-6 hours.

Dosages biltricid set individually, depending on the type of pathogen.

According to the instructions biltricid administered to children older than four years and adults in the following dosages:

At 25 mg / kg body weight three times a day for 1-3 days with infections caused by Clonorchis sinensis, Opisthorchis viverrini, Paragonimus westermani.

Application biltricid during pregnancy and breastfeeding

In the opinion of biltricid not recommended during the first trimester of pregnancy. Since praziquantel into breast milk, the period of reception biltricid breastfeeding is recommended pause and the next day after dosing.

Drug interaction biltricid

When combined with biltricid anticonvulsants, drugs that induce hepatic cytochrome enzymes P450 dexamethasone can be reduced concentration biltricid main component in plasma. When combined with biltricid drugs inhibit the enzyme cytochrome P450 system of the liver, concentration of praziquantel may instead increase in blood plasma.