Content developed by Marie Fuzzati (IRCCS Mondino Foundation and France Parkinson) and Ludivine Breger (INSERM), in close collaboration with MIUR. For more information or for questions, please contact experimentalmodels@jpnd.eu.

General Information

Mouse: C57BL/6 x 129/SvEvBrd

Mice in which exons 4-5 of the PINK1 gene have been deleted by insertion of a neo probe (PGK-neo-pA) using homologous recombination. This insertion removes the N-terminal portion of the PINK1 protein that contains the kinase activity causing loss of function.

Corresponding human genotype: Autosomal recessive mutation in the PINK1 gene causing a loss-of-function of the protein and leading to early-onset Parkinson’s disease (PARK6).

3 thoughts on “mPINK1 KO/2 (Pink1-/-) – Mouse”

To get more information on the availability of the model you should contact the laboratory that created it. A link to the publication can be found under “references” in the General information section.

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The EU Joint Programme – Neurodegenerative Disease Research (JPND) is the largest global research initiative aimed at tackling the challenge of neurodegenerative diseases, in particular Alzheimer’s. Learn More