In vivo, it’s possible that gamma-asarone may form the alkaloid 3-(dimethylamino)-1-(2,4,5-trimethoxyphenyl)propan-1-one (or its piperidine or pyrrolidine counterpart) leading to psychedelic activity. Evidence exists showing that other allylbenzenes such as eugenol, myristicin, safrole, and elemicin form similar alkaloids in vivo.

Acorus calamus root occasionally produces psychedelic effects in some people, although this is rare. These effects are likely attributed to the alkaloid metabolite 3-(dimethylamino)-1-(2,4,5-trimethoxyphenyl)propan-1-one forming from gamma-asarone in vivo. The human body is capable of creating several different metabolites from gamma-asarone, most of which are presumed to be completely inactive. If inactive metabolites are favored in an individual, it’s possible for calamus root to produce no psychedelic effects.

Amphetamine Analog of Gamma-Asarone

The amphetamine form of gamma-asarone is known as 2,4,5-trimethoxyamphetamine. It’s extremely potent, producing stimulant effects and psychedelic effects with as little as 20 mg. The duration of action is from 8-12 hours. It’s possible that the theoretical 3-(dimethylamino)-1-(2,4,5-trimethoxyphenyl)propan-1-one metabolite of gamma-asarone is also active in this dosage range producing similar effects.