Often referred to as the CIOMS Principles, this document provides criteria for establishing codes of practice or legislation about the use of animals in scientific research. Text of the 1985 guidelines is available here. *UPDATED

This 2000 document discusses recognition and assessment of pain and distress and provides guidance on humane euthanasia. Link is in paragraph 4 - Guidance Document No.19 on “the Recognition, Assessment and Use of Clinical Signs as Humane Endpoints for Experimental Animals Used in Safety Evaluations” from 2000.