The Role of CGRPand Nociceptin in Migraine

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.

Verified June 2005 by National Taiwan University Hospital. Recruitment status was: Recruiting

Sponsor:

National Taiwan University Hospital

ClinicalTrials.gov Identifier:

NCT00155129

First Posted: September 12, 2005

Last Update Posted: December 9, 2005

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The release of the neuropeptide calcitonin gene-related peptide (CGRP) is thought to play a causative role in migraine. Nociceptin immunoreactivity and ORL-1 mRNA have been detected in human trigeminal ganglia where it was co-localized with CGRP. It may play a role in migraine pathogenesis. We are collecting the blood samples of migraineurs for analysis of these neuropeptides.

Further study details as provided by National Taiwan University Hospital:

Estimated Enrollment:

200

Study Start Date:

January 2005

Estimated Study Completion Date:

June 2005

Detailed Description:

The release of the neuropeptide calcitonin gene-related peptide (CGRP) is thought to play a causative role in migraine. Nociceptin immunoreactivity and ORL-1 mRNA have been detected in human trigeminal ganglia where it was co-localized with CGRP. It may play a role in migraine pathogenesis. We are collecting the blood samples of migraineurs for analysis of these neuropeptides.

Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:

3 Years to 50 Years (Child, Adult)

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Yes

Criteria

Inclusion Criteria: patients with headache -

Exclusion Criteria: fever, congenital anomaly, CNS organic lesions

Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00155129