Protein: APOC1_HUMAN

Apolipoprotein C-I

FUNCTION: Appears to modulate the interaction of APOE with beta- migrating VLDL and inhibit binding of beta-VLDL to the LDL receptor-related protein. Binds free fatty acids and reduces their intracellular esterification. more...

SUBCELLULAR LOCATION: Secreted.

TISSUE SPECIFICITY: Synthesized mainly in liver and to a minor degree in intestine. Secreted in plasma. MISCELLANEOUS: Apolipoprotein C-I is present in acidic (APOC1A) and basic (APOC1B) forms in P.paniscus, P.abelii and P.troglodytes and perhaps also in baboons and macaques. In human, the acidic form has become a pseudogene. Apo-CI makes up about 10% of the protein of the VLDL (very low density lipoprotein) and 2% of that of HDL (high density lipoprotein).