CONOSCAN D1250U2
SHOWS - CANNOT COMUNICATE WITH SCANNER-CABLE MAY BE DISCONECTED-SCANNER DRIVER WILL BE CLOSED.
ALSO- UNABLE TO OPEN TWAIN SCOURCE-PLEASE CHECK CONNECTION THEN RESTART TOOL BOX.
CABLE IS CONNECTED WHAT CAN I DO?
JOE

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Sounds like the driver is corrupted. Go to this page courtesy of Epson:
http://www.epson.com/cgi-bin/Store/support/supDetail.jsp?BV_UseBVCookie=yes&oid=41625&infoType=Downloads
Download the twain driver for your operating system, then go ahead and download Epson Easyprint for your computer as well.
Install the twain driver and then the Epson Easyprint software and the scanner should work then.

Have you checked the cord from the scanner lid to the scanner base. if that doesn't work I would try uninstalling the scanner and then reinstalling it. It sounds like a problem with the twain driver for the scanner.

Have you tried downloading the drivers/software for your flatbed scanner on the canon website? If your using the disk that came with the device, there is a great chance that it's cirrupted that's why it's prompting you for the CS-U twain driver.

Power off the Epson. Your twain software did not install correctly.
Uninstall the software you installed for the perfection 1250.
Go to Epson's link listed below & download the twain driver.
Pick your operating system & choose the twain driver.