Scientists at the National Institute of Neurological Disorders and Stroke (NINDS) seek adults with frontal lobe lesions for
a longitudinal, prospective study of cognitive function.

To be eligible, patients must be between the ages of 16 and 70 and have a single focal lesion of the frontal lobes. Some of
the possible causes of such frontal lesions include: brain abscess, embolic stroke, intracerebral hemorrhage, tumor, partial
surgical resection, arteriovenous malformation, congenital hypoplasia, aplasia porencephalic cysts, and penetrating head injuries.
Patients will not be eligible if they have ongoing, severe medical illness or other problems precluding successful serial
follow-up. A partial list of exclusion criteria includes history of: generalized or multifocal brain injury, mental retardation,
precocious puberty, severe closed head trauma, elevated intracranial pressure, radiation therapy, intractable epilepsy, neonatal
intraventricular hemorrhage, congenital hydrocephalus from any cause, or the presence of a ventriculoperitoneal shunt.

Studies to be done at the National Institutes of Health (NIH) Clinical Center in Bethesda, MD, include magnetic resonance
imaging, neurologic examination and history, and cognitive testing. Records of all studies and evaluations will be made available
to the referring physician. All study-related expenses and certain travel expenses will be paid by the NIH.