The intestinal epithelium is very peculiar for its continuous cell renewal, fuelled by multipotent stem cells localized within the crypts of Lieberkühn. (nih.gov)

Several lines of evidence have established the evolutionary conserved RNA-binding protein Musashi1 as a marker of adult stem cells, including those of the intestinal epithelium , and revealed its roles in stem cell self-renewal and cell fate determination. (nih.gov)

In conclusion, the targeted expression of Musashi1 in the intestinal epithelium in vivo increases the cell proliferation rate and strongly suggests its action on stem cells activity. (nih.gov)

Our observations suggest a critical role for IL-1b-induced choroidal degeneration leading to long-term sub- and outer-retinal disorder following OIR/ROP, as a result of marked hypoxia. (arvojournals.org)

To further study the mechanism of corneal epithelial metaplasia in Pnn mutant, we explored the alteration in cell fate specification of Pnn deficient corneal epithelia and investigated how Pnn inactivation leads to altered Wnt signaling in corneal epithelium. (arvojournals.org)

The high degree of apoptosis and compromised wound healing observed in the cornea of the L7M1 KO mice suggests immunoproteasome may play an important role in maintaining corneal homeostasis. (arvojournals.org)

Our overall hypothesis is that epithelial cells of the infant lung play a central role in the initiation of the asthma phenotype, via constitutive CCL20 chemokine expression to promote airways recruitment of chemokine receptor CCR6+ T lymphocytes. (grantome.com)

We have previously shown that a carbohydrate-dependent association between galectin-3 and highly O-glycosylated mucins contributes to form an apical barrier at the ocular surface epithelia. (arvojournals.org)

The ability of foetal rat salivary epithelium, particularly from the parotid gland, to develop morphogenetically and functionally (amylase activity) in various mesenchymes, and the quantitative effects of altering mesenchymal mass on the development of the parotid epithelium, have been studied in vitro . (biologists.org)

The experiments proposed within this application will contribute to our overall understanding of how the epithelium of the maturing postnatal lung can direct the development of a pathologic immune response to inhaled allergens. (grantome.com)

Medical and graduate students, postdoctoral and clinical fellows, as well as clinicians interested in the mechanistic basis for lung disease will benefit from the books examination of principles of lung epithelium functions in physiological condition. (elsevier.com)

Retrograde signaling from the brain to the olfactory sensory epithelium is important for neuronal survival, but the importance of the olfactory bulb in retrograde signaling during the naturally-induced, neuronal plasticity occurring during metamorphosis is unclear. (uwindsor.ca)

Important for the barrier function of intenstinal epithelium, its cells are joined securely together by four types of junctions (cell junctions), which can be identified at the ultrastructural level: Gap junctions Desmosomes Adherens junctions Tight junctions Gap junctions bring the adjacent cells within 2 nanometers of each other. (wikipedia.org)

From these results we concluded that relaxation seen in this system is not due to tissue hypoxia but due to the release of relaxing factor from tracheal epithelium. (nii.ac.jp)

The results are interpreted in terms of morphogenetic and growth control of salivary epithelium by mesenchyme, the subsequent cytodifferentiation of the terminal buds being typical of the organ from which the epithelium was derived. (biologists.org)

The olfactory system of the African clawed frog ( Xenopus laevis ) undergoes dramatic rearrangements during metamorphosis, making this an ideal system in which to examine interactions between the brain and the olfactory sensory epithelium. (uwindsor.ca)

When compared to normal tissue, all GC epithelia had lower levels of FOXO4 located in the nucleus, consistent with less FOXO4 effector activity and FOXO4's function as a suppressor of carcinogenic properties. (wikipedia.org)

Our data demonstrate that sAC is expressed by the RPE and that it contributes to the generation of the LP. Further study will be necessary to determine how cAMP generated by sAC may be involved in the LP response as a role for cAMP in generating the LP has not previously been observed. (arvojournals.org)

Further evidence of the role of gut flora in the cause of inflammatory bowel disease is that IBD-affected individuals are more likely to have been prescribed antibiotics in the 2-5 year period before their diagnosis than unaffected individuals. (wikipedia.org)