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Common antidepressant may affect youths bone development

12.11.2004

Effect of SSRIs on bone accrual

A common class of drugs prescribed to children with depression may have an adverse effect on bone growth, according to a study published online in the journal Endocrinology by researchers at the Indiana University School of Medicine.
Researchers looked at the effect of selective serotonin-reuptake inhibitors (SSRIs) on bone accrual in growing mice. The findings showed a reduction in bone mass and size in the mice administered an SSRI.

"These findings indicate a potential negative impact of SSRIs on the skeleton and point to a need for further research into the prescribing of these drugs to children and adolescents," said lead author Stuart J. Warden, P.T., Ph.D., assistant professor in the Department of Physical Therapy, IU School of Health and Rehabilitation Sciences.

The study investigated the effects of fluoxetine, more commonly known as Prozac®, on bone growth in young mice. Dr. Warden and his colleagues selected fluoxetine because it is the only prescription antidepressant currently approved by the FDA for children and adolescents.

IU researchers began their investigation after preliminary clinical evidence released in other studies showed that SSRI use has been associated with increased bone loss at the hip in elderly women, decreased bone density among men and decreased skeletal growth in children.

It is estimated that as many as 10 percent of children and adolescents suffer from depression. "Bone development early in life is believed to determine lifelong skeletal health," said Dr. Warden. "Anything that affects normal bone development may have far-reaching consequences later in life when the skeleton is more prone to fracture."

Cellulose obtained from wood has amazing material properties. Empa researchers are now equipping the biodegradable material with additional functionalities to produce implants for cartilage diseases using 3D printing.

It all starts with an ear. Empa researcher Michael Hausmann removes the object shaped like a human ear from the 3D printer and explains:

The phenomenon of so-called superlubricity is known, but so far the explanation at the atomic level has been missing: for example, how does extremely low friction occur in bearings? Researchers from the Fraunhofer Institutes IWM and IWS jointly deciphered a universal mechanism of superlubricity for certain diamond-like carbon layers in combination with organic lubricants. Based on this knowledge, it is now possible to formulate design rules for supra lubricating layer-lubricant combinations. The results are presented in an article in Nature Communications, volume 10.

One of the most important prerequisites for sustainable and environmentally friendly mobility is minimizing friction. Research and industry have been dedicated...