Non-small cell lung cancer (NSCLC) is the number one cause of cancer-related death and, like all cancers, requires metabolic reprogramming to support the energetic and biosynthetic demands of the tumor cells to proliferate and survive the tumor...

Recent advances in understanding the molecular mechanisms of mutagenesis indicate that most mutations are dependent on the activity of translesion synthesis DNA polymerases. The impact of reducing the level of these polymerases on mutagenesis and...

The following dissertation was aimed at characterizing the metabolic disruptions that occur with selenite treatment in human lung cancer. Specifically, the pathways of glycolysis, TCA cycle, nucleotide metabolism, pentose phosphate pathway,...

BACKGROUND: The parotid gland plays an integral part in digestion, immunity, and oral health. Parotid Secretory Protein (PSP, BPIFA2E) is an abundant protein that is secreted into the oral cavity. To understand the unique molecular mechanisms of...

The reaction between an aminooxy moiety (RONH2) and a carbonyl group of either an aldehyde or a ketone — known as an oximation reaction — is a versatile click chemistry coupling that generates a robust oxime ether linkage. The oximation...

In the age of high-throughput molecular biology techniques, scientists have incorporated the methodology of in-situ hybridization to map spatial patterns of gene expression. In order to compare expression patterns within a common tissue structure,...

Guanine-rich oligonucleotides (GROs) are being developed as a novel anticancer agents. GROs exhibit potent antiproliferative properties against several malignant cell lines and in established in vivo tumor models. In a recent Phase I clinical trial...

In the retina, the receptive fields (RFs) of most neurons are comprised of an excitatory center and a suppressive surround. Retinal ganglion cell (RGC) RF center excitatory input arises from bipolar cell (BC) inputs, while their surround arises...

Polymorphisms in the adrenergic receptor beta-2 (ADRB2) gene have been studied in relation to risk of Type 2 diabetes and obesity, but few studies have investigated associations with breast cancer. The purpose of this research was to evaluate the...

Periodontitis and its systemic sequelae remain a major public health problem and
developing a cost-efficient therapy will benefit healthcare worldwide. Adherence of
Porphyromonas gingivalis to Streptococcus gordonii facilitates colonization of the...

Soon after the atomic theory was established, it was found that the plant uses as sources of food not only the air and water, but also different constituents of the soil, dissolved in the soil moisture—the mineral nutrients. Ashes of different...

In the year 1573 when Shakespeare and Marlowe were already boys of nine, Chapman in adolescence, Spenser, Lyly and Richard Hooker men of twenty, John Donne, then important to only a few but destined to the company of royalty, was born. Walton...

Obesity is a strong risk factor for developing type 2 diabetes and cardiovascular disease and has quickly reached epidemic proportions with few tangible and safe treatment options. While it is generally accepted that the primary cause of obesity is...

Pheromones are an important type of chemical cue used by most animals to convey information between individuals. For more than 100 million years, male plethodontid salamanders have utilized a system of non-volatile, proteinaceous pheromones to...

United States. Army--History; Federal aid to law enforcement agencies--United States; Riots--United States

The function of the army of the United States is to protect the country against all enemies foreign and domestic. Everyone is cognizant of the accomplishments of the American forces against its foreign enemies; but there is another work, of equal...

Since its development, nuclear magnetic resonance (NMR) has become one of the primary methods of chemists for structure elucidation, which is the determination of a compound's molecular structure. Current software packages enable scientists to...

The current status of our knowledge of synaptic plasticity comes largely from studies of the hippocampus and the context of learning and memory. We remain largely ignorant of plasticity in other neural systems and contexts. The molecular basis of...