occular myasthenia gravis

AUTOIMMUNE DISEASE: Myasthenia gravis is a one of the rare autoimmune diseases with a well-defined antigen. Autoantibodies directed against the muscular acetylcholine receptor (AChR) play a key role, blocking the acetylchoroquine binding site and provoking accelerated receptor degradation; complement destroys the post-synaptic membrane. Disease severity is correlated with extent of AChR loss. THYMUS: Involvement of the thymus is suggested by the beneficial effect of thymectomy and by histological and functional anomalies (modified cellular composition, abnormally activated lymphocytes, sensitivization of certain lymphocytes to AChR)...