Wences Casares and Meyer "Micky" Malka are serial entrepreneurs who believe in the fundamental power of partnerships. Empowered by working in close collaboration for years, these co-founders have started multiple companies including Patagon, Lemon Bank and Bling Nation. In this revealing lecture, Casares and Malka describe the value of over-communication, the decision process in making a pivot, and the challenges of entrepreneurial ecosystems outside the United States.

Hugh Martin, Chairman and CEO of Pacific Biosciences, looks back on the evolution of his career - from building computers to creating the future of medicine. Martin charts the lessons he learned working for large technology firms, as a leader in several successful start-ups, and while being courted by the VC community to launch a new wave in bioscience.

Joe McCracken, Vice President of Business Development at Genentech, walks through the founding and growth phase of the company. In particular, McCracken describes the culture at Genentech, which is credited for consistent ground breaking R&amp;amp;D and the resulting financial success.

How do we love all of the children of all species for all time? The unlikely answer comes from architect, materials designer, VC, and eco-efficiency expert William McDonough, who sees the challenge of cycling biological and technical "nutrients" as industry's ultimate goal.

Amyris Biotechnologies CEO John Melo explains his company's endeavors in the sustainable sciences; working both to fight disease and to create renewable energies. Melo also reflects upon his personal career path, from immigrant, to start-up, to Big Oil - and back to start-up again.

In this lecture, Mårten Mickos shares the benefits and challenges involved in building businesses in the open source and cloud computing spaces. As the CEO of Eucalyptus Systems, Mickos identifies a vision for the future of his industry and shares entrepreneurial lessons gained from leading MySQL AB from its startup origins to becoming one of the largest open source companies in the world.

Stanford Engineering lecturer and FLOODGATE partner Ann Miura-Ko offers insight into the democratization of innovation in the Internet age, and its affect on investment cycles. Additionally, Miura-Ko speaks candidly about the need to test business models, her firm's desire to be an advocate for "thunder lizard" entrepreneurs, and the challenges of achieving true work/life balance.

In this high-energy lecture, Geoffrey Moore discusses how companies can build the escape velocity necessary to move beyond the successes and failures of the past. Moore argues that when companies focus too much on performance, they miss out on building the power to become the industry leaders that other companies envy. He shares a hierarchy model through which companies can examine and build power, and examines how product teams can best work to differentiate their company, neutralize the competition, and optimize products and offers.

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