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Georges St-Pierre was originally scheduled to defend his title in the category Welterweight against Nick Diaz in the main event. However, on 7 December 2011 it was revealed that St-Pierre was injured and could not join the fight. Diaz instead faced Carlos Condit.[3] The original opponent for Condit, Josh Koscheck, faced Mike Pierce at this event.[4]

The following is the reported payout to the fighters as reported to the Nevada State Athletic Commission. It does not include sponsor money and also does not include the UFC's traditional "fight night" bonuses.[10]