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Medication Update: Tamoxifen investigated as mania treatment

Medication Update

Tamoxifen investigated as mania treatment

Although tamoxifen is best known as a hormonal treatment for
breast cancer, a pilot study indicates that it may also be useful
in treating acute mania in patients with bipolar disorder.

Tamoxifen works mainly by inhibiting estrogen, but laboratory
experiments indicate that it also inhibits enzymes in the protein
kinase C (PKC) family, which are active in the brain as well as
other parts of the body. Researchers decided to test tamoxifen as
a treatment for mania after laboratory studies indicated that PKC
may contribute to manic behavior.

Researchers randomly assigned 16 men and women with bipolar
disorder to receive tamoxifen (20 mg to 140mg per day) or
placebo. Doses were adjusted up or down, depending on response
and side effects. All participants had been diagnosed years
earlier with bipolar disorder and had taken at least one
medication previously.

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Daily Health Tip

Check in with your memory

Not remembering where you put your car keys or forgetting the birthday of a neighbor is normal. Getting lost in what should be a familiar surrounding isn't. If you are worried about your memory, schedule a cognition test with your doctor.