The premise of the story is painfully cliché, although it is handled in a fairly interesting manner. As it is not yet finished, the main plot is not completely clear. It is known that a genetic engineer by the name of Kelvin abducted a number of teenagers and had them turned into "Pokémon hybrids" (Involuntary Shapeshifters who transform into Legendary Pokémon at random times). He planned on using them as an army to take down Team Plasma, but was captured and imprisoned before he had the chance to even tell the hybrids what happened to them. It's eventually revealed that he intended to use the hybrids to avenge a former lover. While Kelvin was dealt with, his creations were left abandoned. Unbeknownst to N (who was on a research trip), Ghetsis took matters into his own hands by calling off all of Team Plasma's projects and instructing them to hunt down the missing hybrids. On top of delving into the struggles of several Pokémon hybrids and the Team Plasma grunts who are trying to capture them, the story also explores N's upbringing and ambitions, Ghetsis's motivations, the creation of Genesect, and what bonds humans and Pokémon truly share.

The story is told in third person, but each chapter follows one of six main characters:

Destiny, an optimistic but cowardly girl who has been fused with Genesect. She isn't particularly bright or talented, and she frequently ponders her importance in the world. While she is generally portrayed as cheerful, she has a tendency to break down in the event of a major problem and she also displays antipathy towards certain people. Although she is revolted by her Pokémon form, she seems to enjoy taking advantage of its power and intimidating appearance.

Drake (referred to as Dragon), a calm and somewhat sympathetic Team Plasma grunt. He is very self-conscious about the way he presents himself, and he tries to disguise himself as a tough guy to hide the fact that he's sensitive and insecure at heart. He is suspicious about Team Plasma's motives from the start, and he claims he only joined because he wanted to make a difference in the world. He questions the authenticity of Team Plasma more and more as the story progresses. His signature Pokémon is an Archeops.

Colby, an upbeat and happy-go-lucky rookie trainer. While searching for Pokémon to battle, he stumbles upon Destiny and Aurelia and is thrown into their mess of troubling situations. He is eager to help the two hybrids, but at the same time he wants to follow his own dreams. He is driven by the desire to become a hero, and he is slightly envious of Aurelia and Destiny's abilities to transform into Pokémon. His starter Pokémon was a Sandile.

Aurelia, a very bad-tempered and cynical Arceus hybrid. She has a Dark and Troubled Past, which she often uses as a way to get pity and draw attention to herself. She is narcissistic and highly unsympathetic. She is a strong believer in fate (which she considers to be cruel and unforgiving, especially to her), and blames all of her bad experiences on it. When she is assuming her Arceus form, her attitude becomes even worse than it usually is. Prior to when she was turned into a hybrid, she was a reasonably skilled Pokémon trainer—consequently, she has a lot of street smarts.

Ben, a Zekrom hybrid who is often seen as a geek. Unsurprisingly, he is very intelligent, especially when it comes to Pokémon. He hoped to one day become a Pokémon researcher, but upon turning into a hybrid his dreams were ultimately crushed. Unlike Destiny and Aurelia, he initially enjoys being a hybrid. He is bold and headstrong, and rarely takes things seriously unless a Pokémon's welfare is on the line. He often questions people and likes to debate. He is captured by Team Plasma early in the story.

N, the apparent leader of Team Plasma. Instead of seeking to revive Reshiram or Zekrom, he shows an interest in recreating the "Great Dragon", or Reshiram and Zekrom's original, united form. He is not present in the first part of the story because he is off on a research trip. When he returns, he is greeted with a mess of problems. It doesn't take long for him to find out about how Ghetsis commanded Team Plasma to take down the hybrids or how the corrupt officials have been working on modifying Genesect, and he is less than pleased about both situations. Because of what Ghetsis taught him as a child, he defiantly opposes genetically altered organisms and considers Mercy Killing both Genesect and the hybrids, although he is also strongly against killing anything.

Plasma's Folly contains examples of:

0% Approval Rating: Part of Kelvin's plot involves Team Plasma's approval rating plummeting due to their slaughtering of innocent young people.

Abandoned Hospital: Destiny compares the building she woke up in to a recently abandoned hospital.

Achilles' Heel: When Dragon tries to take down Genesect, he finds that none of Archeops's moves damage it. Ghetsis shows up shortly after and yanks out its drive, which "kills" it instantly.

A God Am I: Aurelia lets her transformation into Arceus get to her head in "Human":

Aurelia:I am God! I can never be captured!

She later claims that she felt as if Arceus's mind had taken control of her body, but the authenticity of her statement is questionable.

Big Eater: Justified with Ben in that he was assuming the form of a Pokémon that has a greater stomach capacity than a human. Since this was only temporary, it led to some unfortunate consquences when he returned to normal.

Break the Cutie: When N was a child, Ghetsis gave him numerous Pokémon to play with. All of these Pokémon were suffering from life-threatening injuries, and died shortly thereafter. N is still haunted by these experiences, as evidenced in "Verdict".

Aurelia: Oh? Why would you say that? Yeah, because the real Zekrom hasn’t been dead for centuries, and of course it would choose to hang out in a place crawling with kids who can turn into Legendary Pokémon.

Kelvin's also had a few moments of sass.

Ben: You’re telling me that if I get laid, the chick will be stuck turning into Zekrom, too?

Did I Just Say That Out Loud?: Ben's plans to stealthily escape the P2 Laboratory are quickly derailed when Dragon reveals he was unknowingly projecting his thoughts out loud in the form of Telepathy.

Dirty Coward: It was Kelvin's intention to wind up imprisoned by Team Plasma because he feared being apprehended for his murderous experiments.

Disproportionate Retribution: Basically the entire premise of the plot. Kelvin assembles an army of fifty kids who can turn into Legendary Pokémon to outright obliterate Team Plasma because his girlfriend was made into Genesect.

Don't Call Me "Sir": Kelvin insists on being called by his first name because he does not think he is worthy of a title.

Dragged by the Collar: To bring Ben to the P2 Laboratory, Dragon has his Archeops bite down on the hood of his sweatshirt and carry him away.

Dragon: (thinking) I wonder what that sweatshirt’s made out of. It’s a miracle it’s so durable.

Aurelia:I’ve been abandoned by my entire family. And now the only thing I’ve had to live for, Pokémon training, has been stolen from me as well. I’m starting to wonder why I still cling to this pathetic existence. Burning in Hell would be just as enjoyable.

Dumb Blonde: All three of the blonde-haired characters aren't exactly known for their intelligence. They're especially bad at planning and thinking things through.

As a shout-out, Aurelia uses the nickname in passing in "Lost and Found".

Fantastically Indifferent: Aurelia isn't surprised in the slightest to find herself in the abandoned building. She has a stronger reaction to her transformation, but she does a good job hiding it at first.

Fearless Fool: Colby boldly challenges an obviously more skillful Lynn... only to have his Sandile knocked out in one hit.

Flawed Prototype: Genesect is considered to be a prototype hybrid, or at least the only one to survive its initial transformation.

There's a brief part in Aurelia's debut chapter that hints at the identity of her Pokémon form.

Lynn delivers a hint at Colby's death in "Encounter".

Lynn:You might want to try looking for Pokémon elsewhere if you want to avoid being torn to shreds.

There are a number of clues leading up to the revelation of Genesect's true identity.

Genesect is referred to as a female for seemingly no reason, whereas no other Legendary Pokémon are gendered.

Dudley drops one regarding the authenticity of his second story.

Dragon points out that Genesect acts a like a human.

The Ditto's early appearance more or less hints at its involvement in the creation of the hybrids.

From Bad to Worse: At this rate, it doesn't look like Destiny and Aurelia's experiences in the forest are going to get any better.

Frozen Face: While assuming her Genesect form, Destiny's face is locked in a grin and thus she is incapable of displaying emotion.

The same obviously applies to the original Genesect as well.

Geek Physiques: Ben falls into the skinny category... until his mishap in the Team Plasma HQ's dungeon.

Genre Savvy: Aurelia warns that when people split up in TV and movies, something always goes wrong.

Ghostly Chill: Destiny experiences one when the ghost of Colby visits her in her nightmare.

Ghost Story: When N states that he believes the Light Stone can be found in Dragonspiral Tower, Ben, a resident of Icirrus City, starts to ramble about how the kids at his school would always tell stories about someone sneaking into it and never returning.

Girl on Fire: "Night Terror" ends with Destiny being set ablaze by an enraged Ditto.

Glass Cannon: Aurelia refers to Skyla's Swoobat as this in "Reflections".

Jerk with a Heart of Jerk: Any redeeming qualities Kelvin may have possessed are quickly negated when he reveals the true objectives of his scheme.

Just Between You and Me: When Ben begins to suspect that Kelvin is being dishonest, Kelvin decides to give away the full details of his plan. Though it would normally be decidedly foolish to reveal this to someone who can turn into a Legendary Pokémon (as lampshaded by Ben), he easily proceeds to convince him not to do anything.

Killer Rabbit: Once the Ditto reveals its true form, Aurelia decides it isn't a threat... until Destiny manages to make it angry.

"Broken" features a flashback in which Ghetsis gives a young N a baby Deino to take care of. While their relationship is shaky at first, the two eventually form a close bond... until Ghetsis snaps the Deino's neck as part of a demonstration in which he exposes the "true evils of Pokémon trainers".

Another (perhaps more extreme) example of this trope is present in "Chrysalis". The cheerful Colby meets his untimely and unnecessarilygruesome death when he stumbles upon a faulty vial of the formula and makes the not-so-bright decision of injecting himself with it.

Lack of Empathy: A trait shared by both Ben and Kelvin, who will do whatever it takes to advance themselves even if it means others will suffer.

Laser-Guided Amnesia: The hybrids wake without knowing how they ended up in the building. Their memories from directly before the abduction are foggy.

Leeroy Jenkins: Colby, when he's trying to rescue his hybrid friends from Lynn and her Galvantula. Instead of devising a more logical plan (such as having Sandile cut down the fence right away, like Lynn later suggests), Colby makes Sandile attack Galvantula without considering what could go wrong.

LEGO Genetics: The hybrids were infused with a formula containing specifically programmed Ditto DNA, giving them the ability to transform into a certain Pokémon.

Names to Run Away from Really Fast: Parodied with Drake, who appointed himself the nickname "Dragon" in hopes that it would make him appear imposing. Unfortunately for him, most people take it as a joke.

Nay-Theist: Ben knows that Arceus exists, but he refuses to believe that it has anything to do with fate or destiny and that there is an afterlife.

No Sympathy: Aurelia likes to use her traumatic experiences as an excuse to be an unsympathetic bitch. This is especially evident at the end of "Lost and Found".

Aurelia:Just accept it. People die every day; it’s an unavoidable part of life. Some people have died for crazier, even more perplexing reasons than this. Denying it won’t bring Colby back to life.

Additionally, Destiny feels absolutely no sympathy towards Aurelia.

Obliviously Evil: As in canon, N and the majority of Team Plasma believe their actions will benefit the Unova region.

Obfuscating Stupidity: Kelvin reveals to Ben that his supposed plot was intentionally ridiculous because he had something different in mind for the hybrids all along.

Kelvin:Did you really think I turned fifty kids into monsters to send them to war against Team Plasma? Even a fool would know that’s absolutely absurd! There is no logic in the notion of convincing a band of rebellious teenagers to fight an organization they had nothing to do with. It was all a cover-up; a trick I knew Team Plasma would fall for.

Offing the Offspring: Destiny's father comes seconds from doing this, although he is unaware that the "monster" he is about to shoot is actually his daughter.

Oh, Crap!: Ben's reaction when he finds out he can use telepathy in a very inconvenient time.

Only Sane Man: Ben has trouble making sense of anything Team Plasma does, and considers himself to be the only rational person among them. He frequently questions them, and treats most of their goals as jokes.

Red Oni, Blue Oni: Ben and Dragon, although the former is more book smart than the latter.

The same applies to Aurelia and Destiny.

Revenge Before Reason: After his failed formula kills his first subject, Kelvin doesn't stop to consider that the approach he has in mind might not be the most rational option. Desperate for vengeance, his plans become even more unreasonable.

Kelvin: When one’s love intervenes, men become beasts. I suppose it is just human nature to use irrational means to set things right.

When Aurelia questions Destiny's father if he's actually seen any of the hybrids hurting anyone, he changes the subject.

Roaring Rampage of Revenge: Destiny's father, who believes his daughter has been murdered by hybrids, has been ruthlessly slaughtering any that walk into Mistralton City.

Swiss Cheese Security: The door to the room holding Genesect was equipped with numerous locks, but for some reason they were left unhinged.

Switching P.O.V.: The story, which is written in a third person limited format, rotates between the perspectives of Destiny, Dragon, Colby, Aurelia, Ben, and N. A series of one-shots following minor characters has also been planned.

Telepathy: Aurelia can communicate while transformed via telepathy. Ben can as well, but he isn't aware of this at first.

Thou Shalt Not Kill: After witnessing the deaths of many Pokémon when he was a child, N is very opposed to killing. This becomes a bit of a problem when he realizes that Genesect may be better off dead.

Kelvin:In a way, Plasma succeeded. They created a near perfect replica of GMP 156, and gave it human intelligence to boot. Of course, the torture they put my love through to reach this is unforgivable.

Time for Plan B: When Ben is caught thinking out loud about making a stealthy escape from the P2 Laboratory, he utters this as he kicks a hole through the wall.

Too Dumb to Live: Even if the formula hadn't been faulty, common sense says it still wouldn't have been a very good idea for Colby to inject himself with a random syringe he found sitting in a paper bag.

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