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Press ReleaseWalking on ice takes more than brains
Salk scientists discover how a 'mini-brain' in the spinal cord aids in balance

LA JOLLA--Walking across an icy parking lot in winter--and remaining upright--takes intense concentration. But a new discovery suggests that much of the balancing act that our bodies perform when faced with such a task happens unconsciously, thanks to a cluster of neurons in our spinal cord that function as a "mini-brain" to integrate sensory information and make the necessary adjustments to our muscles so that we don't slip and fall.

In a paper published January 29, 2015 in the journal Cell, Salk Institute scientists map the neural circuitry of the spinal cord that processes the sense of light touch. This circuit allows the body to reflexively make small adjustments to foot position and balance using light touch sensors in the feet. The study, conducted in mice, provides the first detailed blueprint for a spinal circuit that serves as control center for integrating motor commands from the brain with sensory information from the limbs. A better understanding of these circuits should eventually aid in developing therapies for spinal cord injury and diseases that affect motor skills and balance, as well as the means to prevent falls for the elderly.

"When we stand and walk, touch sensors on the soles of our feet detect subtle changes in pressure and movement. These sensors send signals to our spinal cord and then to the brain," says Martyn Goulding, a Salk professor and senior author on the paper. "Our study opens what was essentially a black box, as up until now we didn't know how these signals are encoded or processed in the spinal cord. Moreover, it was unclear how this touch information was merged with other sensory information to control movement and posture."

While the brain's role in cerebral achievements such as philosophy, mathematics and art often take center stage, much of what the nervous system does is to use information gathered from our environment to guide our movements. Walking across that icy parking lot, for instance, engages a number of our senses to prevent us from falling. Our eyes tell us whether we're on shiny black ice or damp asphalt. Balance sensors in our ear canals keep our heads level with the ground. And sensors in our muscles and joints track the changing positions of our arms and legs.

Every millisecond, multiple streams of information, including signals from the light touch transmission pathway that Goulding's team has identified, flow into the brain. One way the brain handles this data is by preprocessing it in sensory way stations such as the eye or spinal cord. The eye, for instance, has a layer of neurons and light sensors at its back that performs visual calculations--a process known as "encoding"--before the information goes on to the visual centers in the brain. In the case of touch, scientists have long thought that the neurological choreography of movement relies on data-crunching circuits in the spinal cord. But until now, it has been exceedingly difficult to precisely identify the types of neurons involved and chart how they are wired together.

In their study, the Salk scientists demystified this fine-tuned, sensory-motor control system. Using cutting-edge imaging techniques that rely on a reengineered rabies virus, they traced nerve fibers that carry signals from the touch sensors in the feet to their connections in the spinal cord. They found that these sensory fibers wire together in the spinal cord with another group of neurons known as RORα neurons, named for a specific type of molecular gate found on each cell's nucleus. The RORα neurons in turn connect with neurons in the motor region of brain, suggesting they might serve as a critical link between the brain and the feet.

When Goulding's team disabled the RORα neurons in the spinal cord using genetically modified mice developed at Salk, they found that these mice were substantially less sensitive to movement across the surface of the skin or to a sticky piece of tape placed on their feet. Despite this, the animals were still able to walk and stand normally on flat ground.

However, when the researchers had the animals walk across a narrow, elevated beam, a task that required more effort and skill, the animals struggled, performing more clumsily than animals with intact RORα neurons. The scientists attribute this to the animals' reduced ability to sense when a foot was slipping off the edge and respond accordingly with small adjustments in foot position and balance--motor skills similar to those necessary for balancing on ice or other slippery surfaces.

Another important characteristic of the RORα neurons is that they don't just receive signals from the brain and the light touch sensors, but also directly connect with neurons in the ventral spinal cord that control movement. Thus, they are at the center of a "mini-brain" in the spinal cord that integrates signals from the brain with sensory signals to make sure the limbs move correctly.

"We think these neurons are responsible for combining all of this information to tell the feet how to move," says Steeve Bourane, a postdoctoral researcher in Goulding's lab and first author on the new paper. "If you stand on a slippery surface for a long time, you'll notice your calf muscles get stiff, but you may not have noticed you were using them. Your body is on autopilot, constantly making subtle corrections while freeing you to attend to other higher-level tasks."

The team's study represents the beginning of a new wave of research that promises to provide precise and comprehensive explanations for how the nervous system encodes and integrates sensory information to generate both conscious and unconscious movement.

"How the brain creates a sensory percept and turns it into an action is one of the central questions in neuroscience," adds Goulding. "Our work is offering a really robust view of neural pathways and processes that underlie the control of movement and how the body senses its environment. We're at the beginning of a real sea change in the field, which is tremendously exciting."

Sensory circuits in the dorsal spinal cord integrate and transmit multiple cutaneous sensory modalities including the sense of light touch. Here, we identify a population of excitatory interneurons (INs) in the dorsal horn that are important for transmitting innocuous light touch sensation. These neurons express the ROR alpha (RORα) nuclear orphan receptor and are selectively innervated by cutaneous low threshold mechanoreceptors (LTMs). Targeted removal of RORα INs in the dorsal spinal cord leads to a marked reduction in behavioral responsiveness to light touch without affecting responses to noxious and itch stimuli. RORα IN-deficient mice also display a selective deficit in corrective foot movements. This phenotype, together with our demonstration that the RORα INs are innervated by corticospinal and vestibulospinal projection neurons, argues that the RORα INs direct corrective reflex movements by integrating touch information with descending motor commands from the cortex and cerebellum