To provide an IRB-approved mechanism for the collection of peripheral blood, urine, sputum and bone marrow samples from paid, volunteer donors for use in in vitro studies.

To provide adequate and complete informed consent to the donors of research blood samples, and to assure that the education, counseling and protection of the study subjects from research risks is performed.

150

All

18 Years to 85 Years (Adult, Senior)

NCT00090662

04026604-I-0266

August 31, 2004

September 2, 2004

November 28, 2017

National Institutes of Health Clinical Center, 9000 Rockville PikeBethesda, Maryland, United States

Participant long-term treatment response measured by peak eosinophil count from baseline to 36 weeks for subjects who were randomized to OBS treatment but did not respond after 16 weeks in SHP621-301 induction study