findings indicate that alpha4beta7*IgG can be used as a probe for functional MAdCAM-1 expressed on HEVs in GALT (show GALT Antibodies) and could potentially serve as an anti-inflammatory drug inhibiting GALT (show GALT Antibodies)-specific lymphocyte migration

results suggest that AT1R (show AGTRAP Antibodies) regulates the expression of MAdCAM-1 under colonic inflammatory conditions through regulation of the translocation of NF-kappaB (show NFKB1 Antibodies) into the nucleus

Findings suggest that the inactive alpha4beta7 and alpha4beta7 activated by different stimuli have distinct conformations with different structural requirements for MAdCAM-1 binding.

Ca2 (show CA2 Antibodies)+ is essential for cell tethering in flow and rolling interactions through alpha 4 integrins with MAdCAM-1 as substrate; Mg2 (show MUC7 Antibodies)+ promotes firm adhesion of cells on MAdCAM-1 but with much lower tethering efficiency in shear flow.

A crystal structure for the two extracellular amino-terminal domains of human MAdCAM-1

more extensive expression of MAdCAM-1 in Crohn's disease (CrD (show CRX Antibodies)), than in ulcerative colitis, which could contribute not only to mucosal inflammation, but also to transmural inflammation in CrD (show CRX Antibodies).

MAdCAM-1/integrin alpha4beta7 homing system may participate in gastric inflammation in response to H pylori-infection and contributes to MALT formation, typically leading to the development of nodular gastritis.

Protein Summary

The protein encoded by this gene is an endothelial cell adhesion molecule that interacts preferentially with the leukocyte beta7 integrin LPAM-1 (alpha4beta7), L-selectin, and VLA-4 (alpha4beta1) on myeloid cells to direct leukocytes into mucosal and inflamed tissues. It is a member of the immunoglobulin family and is similar to ICAM1 and VCAM1. At least seven alternatively spliced transcripts encoding different protein isoforms have been found for this gene, but the full-length nature of some variants has not been determined.