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Ryan Gutenkunst, PhD Associate Professor, Molecular and Cellular Biology & of Ecology and Evolutionary Biology University of Arizona Mutation fitness effects across populations and proteins Abstract: The distribution of fitness effects (DFE) among new mutations quantifies how likely a mutation is to have severe, moderate, or minor effect. The DFE is a key determinant of how functional genetic variation is distributed among and within populations, and much research has focused on inferring the DFE from population genetic data. Here, we extend the…