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type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/jcs.biologists.org\/sites\/default\/files\/advagg_css\/css__uXgUByez87OKDsgffPHe7u5qNUzr7zOnqWrSJ87THKk__RR-QNYl6SsTObm37M1MaRCUwwzIP19wUZLcqO_pRc1Q__QG9q5r9tQ7TdXKFmyxYlmSKGTO7DPMVu10_2KBY2QDA.css\u0022 media=\u0022all\u0022 \/\u003E\n\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/cdn.jsdelivr.net\/qtip2\/2.2.1\/jquery.qtip.min.css\u0022 media=\u0022all\u0022 \/\u003E\n\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/jcs.biologists.org\/sites\/default\/files\/advagg_css\/css__14LtxqLbXLYbBfVMMQ9Q34-c_XuRCLysSbYzec2Yg7c__Z0uQp4m9tFiEZP0bFEgoD4CsR3FkQHIP2WAIdv-eq9Y__QG9q5r9tQ7TdXKFmyxYlmSKGTO7DPMVu10_2KBY2QDA.css\u0022 media=\u0022all\u0022 \/\u003E\n\u003Clink rel=\u0027stylesheet\u0027 type=\u0027text\/css\u0027 href=\u0027\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0027 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class=\u0022\u0022\u003EABSTRACT\u003C\/h2\u003E\u003Cp id=\u0022p-2\u0022\u003EAndrew received his first degree in natural sciences from the University of Cambridge and a Masters degree from the University of Manchester, followed by a PhD with Stephen Taylor in Manchester. He then moved to California in 2007 with an EMBO long-term fellowship for his postdoctoral research with Don Cleveland at the Ludwig Institute for Cancer Research. In 2013, Andrew started his own lab as an Assistant Professor in the Department of Molecular Biology and Genetics at the Johns Hopkins University School of Medicine, having been named a Kimmel Scholar and a Pew-Stewart Scholar in 2014. Andrew\u0027s lab investigates the mechanisms controlling centrosome copy numbers during cell division and the links between centrosome amplification, genome instability and tumorigenesis.\u003C\/p\u003E\u003C\/div\u003E\u003Cp id=\u0022p-3\u0022\u003E\u003Cspan class=\u0022highwire-responsive-lazyload\u0022\u003E\u003Cimg src=\u0022data:image\/gif;base64,R0lGODlhAQABAIAAAAAAAP\/\/\/yH5BAEAAAAALAAAAAABAAEAAAIBRAA7\u0022 class=\u0022highwire-embed lazyload\u0022 alt=\u0022Embedded Image\u0022 data-src=\u0022http:\/\/jcs.biologists.org\/sites\/default\/files\/highwire\/joces\/130\/3\/523\/embed\/inline-graphic-1.gif\u0022\/\u003E\u003Cnoscript\u003E\u003Cimg class=\u0022highwire-embed\u0022 alt=\u0022Embedded Image\u0022 src=\u0022http:\/\/jcs.biologists.org\/sites\/default\/files\/highwire\/joces\/130\/3\/523\/embed\/inline-graphic-1.gif\u0022\/\u003E\u003C\/noscript\u003E\u003C\/span\u003E\u003C\/p\u003E\u003Cp id=\u0022p-4\u0022\u003E\u003Cstrong\u003EWhat inspired you to become a scientist?\u003C\/strong\u003E\u003C\/p\u003E\u003Cp id=\u0022p-5\u0022\u003EBecoming a scientist was not part of the plan. At the end of my degree, having done no research, I went to see my advisor and told her that I would like to write a thesis rather than engage in bench research. Luckily, she convinced me that I should give research a try, so I went to the Gurdon Institute and worked in Johnathon Pines\u2019 lab. I was drawn to the intellectual freedom you enjoy as a scientist and I began to fall in love with research. I wasn\u0027t convinced at that stage that this was the career I wanted, but I kept going because I enjoyed it. It was only half way through my postdoc that I made the decision that I wanted to try to run my own lab.\u003C\/p\u003E\u003Cp id=\u0022p-6\u0022\u003E\u003Cstrong\u003EIs this something that still motivates you now?\u003C\/strong\u003E\u003C\/p\u003E\u003Cp id=\u0022p-7\u0022\u003EYes, I love my job. The freedom to be curious and work on interesting questions at the boundary of human knowledge is very satisfying for me. The unexpected path of scientific discovery makes this a very exciting profession. I also get the opportunity to work with bright people and try and help them achieve their goals. It\u0027s a very rewarding career and I feel fortunate to have the privilege of doing this for a living.\u003C\/p\u003E\u003Cp id=\u0022p-8\u0022\u003E\u003Cstrong\u003EWhat is the research focus of your lab?\u003C\/strong\u003E\u003C\/p\u003E\u003Cp id=\u0022p-9\u0022\u003EDuring my postdoc, I developed an interest in centrosomes. These organelles direct the formation of the bipolar spindle upon which chromosomes are segregated. Cells go to great lengths to ensure that they only have two copies of centrosomes when they divide to ensure they faithfully partition the genetic information into two daughter cells. Just like DNA, the centrosomes are replicated only once per cycle. However, while the structure of DNA immediately betrayed a mechanism for how it could be replicated exactly once, there\u0027s nothing intrinsic in the structure of the centrosome that explains how you make a single copy. Part of our lab works on how you make one and only one new centrosome in each cycle. We\u0027re also interested in the consequences of abnormalities in centrosome copy number. Abnormal numbers of centrosomes are very common in human cancers, and we know several neurodevelopmental diseases are caused by mutations in centrosome proteins. We use mouse models to manipulate centrosome number and investigate how this impacts tumorigenesis and brain development.\u003C\/p\u003E\u003Cp id=\u0022p-10\u0022\u003E\u003Cstrong\u003EWhat challenges did you face starting your lab that you didn\u0027t expect?\u003C\/strong\u003E\u003C\/p\u003E\u003Cp id=\u0022p-11\u0022\u003EThere is of course pressure to raise funds to run your group, but there\u0027s also a whole spectrum of additional challenges that you face when you start. One challenge is recruiting talented people and working with them to help them achieve their potential. We typically don\u0027t have a lot of training for this as bench scientists. I find helping people in the lab to achieve their goals to be one of the most satisfying parts of my job.\u003C\/p\u003E\u003Cblockquote id=\u0022disp-quote-1\u0022 class=\u0022disp-quote\u0022\u003E\u003Cp id=\u0022p-12\u0022\u003E\u201cI think you need to be forever young in your approach\u201d\u003C\/p\u003E\u003C\/blockquote\u003E\u003Cp id=\u0022p-13\u0022\u003E\u003Cstrong\u003EDo you have any advice on how to recruit the right people for your group?\u003C\/strong\u003E\u003C\/p\u003E\u003Cp id=\u0022p-14\u0022\u003EI think it\u0027s important to make sure that people you recruit have the right attitude and fit with the atmosphere and culture of the lab. Obviously, when you don\u0027t have a lot of people in your lab it\u0027s important that everyone functions well together.\u003C\/p\u003E\u003Cp id=\u0022p-15\u0022\u003E\u003Cstrong\u003EWhat other challenges do you see in the future?\u003C\/strong\u003E\u003C\/p\u003E\u003Cp id=\u0022p-16\u0022\u003EThe recruitment challenge is always going to be there, and funding pressure is not going away anytime soon. I think there\u0027s a reasonable amount of funding for junior group leaders, but it gets more challenging in the middle of your career as these opportunities diminish and you must compete with well-established labs to raise research funds. It\u0027s important to be continually renewing you research programme and not get stale; I think you need to be forever young in your approach and try to be doing things that are a little different from everybody else.\n\u003C\/p\u003E\u003Cdiv id=\u0022F1\u0022 class=\u0022fig pos-float odd\u0022\u003E\u003Cdiv class=\u0022highwire-figure\u0022\u003E\u003Cdiv class=\u0022fig-inline-img-wrapper\u0022\u003E\u003Cdiv class=\u0022fig-inline-img\u0022\u003E\u003Ca href=\u0022http:\/\/jcs.biologists.org\/content\/joces\/130\/3\/523\/F1.large.jpg?width=800\u0026amp;height=600\u0026amp;carousel=1\u0022 title=\u0022Andrew with his family.\u0022 class=\u0022highwire-fragment fragment-images colorbox-load\u0022 rel=\u0022gallery-fragment-images-279368705\u0022 data-figure-caption=\u0022\u0026lt;div class=\u0026quot;highwire-markup\u0026quot;\u0026gt;\u0026lt;div xmlns=\u0026quot;http:\/\/www.w3.org\/1999\/xhtml\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Andrew with his family.\u0026lt;\/strong\u0026gt;\u0026lt;\/div\u0026gt;\u0026lt;\/div\u0026gt;\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003E\u003Cspan class=\u0022hw-responsive-img\u0022\u003E\u003Cimg class=\u0022highwire-fragment fragment-image lazyload\u0022 alt=\u0022Figure1\u0022 src=\u0022data:image\/gif;base64,R0lGODlhAQABAIAAAAAAAP\/\/\/yH5BAEAAAAALAAAAAABAAEAAAIBRAA7\u0022 data-src=\u0022http:\/\/jcs.biologists.org\/content\/joces\/130\/3\/523\/F1.medium.gif\u0022 width=\u0022330\u0022 height=\u0022440\u0022\/\u003E\u003Cnoscript\u003E\u003Cimg class=\u0022highwire-fragment fragment-image\u0022 alt=\u0022Figure1\u0022 src=\u0022http:\/\/jcs.biologists.org\/content\/joces\/130\/3\/523\/F1.medium.gif\u0022 width=\u0022330\u0022 height=\u0022440\u0022\/\u003E\u003C\/noscript\u003E\u003C\/span\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cul class=\u0022highwire-figure-links inline\u0022\u003E\u003Cli class=\u0022download-fig first\u0022\u003E\u003Ca href=\u0022http:\/\/jcs.biologists.org\/content\/joces\/130\/3\/523\/F1.large.jpg?download=true\u0022 class=\u0022highwire-figure-link highwire-figure-link-download\u0022 title=\u0022Download Figure1\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload figure\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022new-tab\u0022\u003E\u003Ca href=\u0022http:\/\/jcs.biologists.org\/content\/joces\/130\/3\/523\/F1.large.jpg\u0022 class=\u0022highwire-figure-link highwire-figure-link-newtab\u0022 target=\u0022_blank\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EOpen in new tab\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022download-ppt last\u0022\u003E\u003Ca href=\u0022\/highwire\/powerpoint\/1628025\u0022 class=\u0022highwire-figure-link highwire-figure-link-ppt\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload powerpoint\u003C\/a\u003E\u003C\/li\u003E\u003C\/ul\u003E\u003C\/div\u003E\u003Cdiv class=\u0022fig-caption\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cp id=\u0022p-17\u0022 class=\u0022first-child\u0022\u003E\u003Cstrong\u003EAndrew with his family.\u003C\/strong\u003E\u003C\/p\u003E\u003Cdiv class=\u0022sb-div caption-clear\u0022\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cp id=\u0022p-18\u0022\u003E\u003Cstrong\u003EDo you attend a lot of meetings?\u003C\/strong\u003E\u003C\/p\u003E\u003Cp id=\u0022p-19\u0022\u003EI usually attend about two meetings a year. I always attend the ASCB annual meeting. This is a great way to get a broader overview of what\u0027s going on in the cell biology community and to connect with people. I try not to travel much more because I like to be in the lab doing experiments and I think it is important for me to be present to offer support for people in the lab.\u003C\/p\u003E\u003Cp id=\u0022p-20\u0022\u003E\u003Cstrong\u003EDo you still do a lot of experiments?\u003C\/strong\u003E\u003C\/p\u003E\u003Cp id=\u0022p-21\u0022\u003EI\u0027m not ready yet to retire to my office just yet. Whenever I get a chance, I try to run experiments. I like to start projects and when they look like they might work, hand them off to people in the lab.\u003C\/p\u003E\u003Cp id=\u0022p-22\u0022\u003E\u003Cstrong\u003EWhat is the most important advice you would give to someone about to start their own lab?\u003C\/strong\u003E\u003C\/p\u003E\u003Cp id=\u0022p-23\u0022\u003EFocus on the thrill of discovery and don\u0027t get distracted with less important issues that are not directly related to your science. There will always be trends and areas that receive more attention and funding. But things can change fast, and you should stick to working on what you find interesting.\u003C\/p\u003E\u003Cp id=\u0022p-24\u0022\u003E\u003Cstrong\u003EWhat other elements were key to your success?\u003C\/strong\u003E\u003C\/p\u003E\u003Cp id=\u0022p-25\u0022\u003ELike many scientists, I\u0027m a perfectionist and I prefer to do a few things well and not spread myself too thin. I think the most exciting discoveries come from unexpected directions. Fortune favours a prepared mind \u2013 so keep an open mind and be ready to be surprised.\u003C\/p\u003E\u003Cp id=\u0022p-26\u0022\u003E\u003Cstrong\u003EHow do you achieve a work\u2013life balance when starting a lab?\u003C\/strong\u003E\u003C\/p\u003E\u003Cp id=\u0022p-27\u0022\u003EI think you shouldn\u0027t compromise on what it is that\u0027s important in your life. I recently started a family and, of course, spending time with them is important for me. Fortunately, I have many great role models in my department who are successful scientists with families. I think it is important to set aside time to unwind; this helps to keep your mind fresh.\u003C\/p\u003E\u003Cblockquote id=\u0022disp-quote-2\u0022 class=\u0022disp-quote\u0022\u003E\u003Cp id=\u0022p-28\u0022\u003E\u201cFortune favours a prepared mind \u2013 so keep an open mind and be ready to be surprised\u201d\u003C\/p\u003E\u003C\/blockquote\u003E\u003Cp id=\u0022p-29\u0022\u003E\u003Cstrong\u003EWhat is your advice on establishing successful collaborations?\u003C\/strong\u003E\u003C\/p\u003E\u003Cp id=\u0022p-30\u0022\u003EI identify collaborators after reading their papers and admiring their work. I try and work with careful scientists who want the truth, not just a result.\u003C\/p\u003E\u003Cp id=\u0022p-31\u0022\u003E\u003Cstrong\u003ECould you tell us an interesting fact about yourself that people wouldn\u0027t know from your CV?\u003C\/strong\u003E\u003C\/p\u003E\u003Cp id=\u0022p-32\u0022\u003EOne thing I really love is scuba diving. My wife and I started diving in Egypt. Since then we have scuba dived in Scotland, San Diego, the Caribbean, Australia and the Galapagos. I find it really peaceful under water, because you can\u0027t talk, so you have time to look around and appreciate the beauty of the ocean.\u003C\/p\u003E\u003Cp id=\u0022p-33\u0022\u003E\u003Cstrong\u003EWhat\u0027s the most fun or unusual thing you saw?\u003C\/strong\u003E\u003C\/p\u003E\u003Cp id=\u0022p-34\u0022\u003EHammerhead sharks in the Galapagos. You look up and see their silhouettes circling above you in the water. It\u0027s exhilarating!\u003C\/p\u003E\u003Cdiv class=\u0022section fn-group\u0022 id=\u0022fn-group-1\u0022\u003E\u003Ch2\u003EFootnotes\u003C\/h2\u003E\u003Cul\u003E\u003Cli class=\u0022fn\u0022 id=\u0022fn-2\u0022\u003E\u003Cp id=\u0022p-35\u0022\u003EAndrew Holland was interviewed by Anna Bobrowska, Editorial Intern at Journal of Cell Science. This piece has been edited and condensed with approval from the interviewee.\u003C\/p\u003E\u003C\/li\u003E\u003C\/ul\u003E\u003C\/div\u003E\u003Cul class=\u0022copyright-statement\u0022\u003E\u003Cli class=\u0022fn\u0022 id=\u0022copyright-statement-1\u0022\u003E\u00a9 2017. 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