Uses of Nerlynx:

What do I need to tell my doctor BEFORE I take Nerlynx?

If you have an allergy to Nerlynx (neratinib) or any part of Nerlynx (neratinib).

If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what
signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.

If you take any drugs (prescription or OTC, natural products, vitamins) that must not be taken with Nerlynx (neratinib), like certain drugs that are
used for HIV, infections, or seizures. There are many drugs that must not be taken with Nerlynx (neratinib).

If you are taking St. John's wort. Do not take St. John's wort with Nerlynx (neratinib). This medicine may not work as well.

If you are breast-feeding. Do not breast-feed while you take Nerlynx (neratinib) or for 1 month after you stop Nerlynx (neratinib).

This is not a list of all drugs or health problems that interact with Nerlynx (neratinib).

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check
to make sure that it is safe for you to take Nerlynx (neratinib) with all of your drugs and health problems. Do not start, stop, or change the dose of
any drug without checking with your doctor.

What are some things I need to know or do while I take Nerlynx?

Tell all of your health care providers that you take Nerlynx (neratinib). This includes your doctors, nurses, pharmacists, and dentists.

It is common to have diarrhea, upset stomach, throwing up, or stomach pain with Nerlynx (neratinib). Call your doctor if any of these side effects
get very bad, bother you, or do not go away.

Sometimes, diarrhea has been very bad with Nerlynx (neratinib). This has led to other health problems like fluid loss, low blood pressure, and kidney
problems. Talk to your doctor.

You will need to take another drug called loperamide and do other things to help with diarrhea. Follow what your doctor has told you to do.
Ask your doctor or pharmacist if you are not sure what to do.

Have blood work checked as you have been told by the doctor. Talk with the doctor.

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your
doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing;
tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue,
or throat.

Signs of fluid and electrolyte problems like mood changes, confusion, muscle pain or weakness, a heartbeat that does not feel normal, very
bad dizziness or passing out, fast heartbeat, more thirst, seizures, feeling very tired or weak, not hungry, unable to pass urine or change in
the amount of urine produced, dry mouth, dry eyes, or very bad upset stomach or throwing up.

Signs of kidney problems like unable to pass urine, change in how much urine is passed, blood in the urine, or a big weight gain.

Signs of a urinary tract infection (UTI) like blood in the urine, burning or pain when passing urine, feeling the need to pass urine often
or right away, fever, lower stomach pain, or pelvic pain.

More than 2 bowel movements in 1 day.

Very loose stools (diarrhea).

Loose stools (diarrhea) that will not go away.

Swelling of belly.

What are some other side effects of Nerlynx?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical
help if any of these side effects or any other side effects bother you or do not go away:

If OVERDOSE is suspected:

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was
taken, how much, and when it happened.

How do I store and/or throw out Nerlynx?

Store at room temperature.

Store in a dry place. Do not store in a bathroom.

Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.

Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your
pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.

Consumer Information Use and Disclaimer

If your symptoms or health problems do not get better or if they become worse, call your doctor.

Do not share your drugs with others and do not take anyone else's drugs.

Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.

Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.

Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about Nerlynx (neratinib), please talk
with your doctor, nurse, pharmacist, or other health care provider.

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was
taken, how much, and when it happened.

Disclaimer:
This information should not be used to decide whether or not to take Nerlynx (neratinib) or any other medicine. Only the healthcare provider has the
knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe,
effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Nerlynx (neratinib).
It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that
may apply to Nerlynx (neratinib). This information is not specific medical advice and does not replace information you receive from the healthcare
provider. You must talk with the healthcare provider for complete information about the risks and benefits of using Nerlynx (neratinib).