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It seemed like while I was playing through Dead Money, I had a HELL OF A TIME getting these things to go off while the Ghost People were swinging them around. I mean I used the Holorifle, the Automatic-Rifle, the Police Pistol...in VATS, outside VATS, and out of maybe 50 tries I got them to blow up once (I had a strong character too, on Level 30, maybe level 32 when I finally got around to entering the bunker, with 100 Guns and 90, then 100 Energy Weapons).

I would chalk it up to this just not being very likely or even possible, but Dean SPECIFICALLY tells you to aim for them!

So I walked into the Bitter Springs Recreation Office and found three Giant rats. Scrolling through my inventory to decide how to deal with them, I came across the Gas Bombs I was carrying. Perfect, I thought, as the Gas Bomb's miserable damage-to-weight ratio would make it ideal for use on low-health critters. So I threw one behind the counter and it blew up all three of them. Lo and behold, after being blown up like this their corpses turned partially transparent, and glowed green! --Trogdor