Malaria causes more death and disease than any other parasitic pathogen known today. This multiauthored text covers the important areas of malaria research, particularly focusing on those sectors which are of clinical importance for the understanding of the disease, the parasite, and its vector.

The chapter authors are all leading experts within their own particular fields. The biology and molecular biology of the parasite, the clinical spectrum of the disease, the pathogenesis of malaria, and the immunology and emergence of malaria vaccines are some examples of the scientific spheres that are discussed.

The book is suitable as a text for graduate students and clinicians as well as researchers at universities and companies involved in treating or studying infectious diseases.

PARASITOLOGY FOR MEDICAL LABORATORY TECHNICIANS is the ideal text to guide readers in understanding the background, source, recovery, and identification of a well-representative range of organisms that commonly affect humans. This book organizes a complex set of topics into an understandable and easy-to-read format that will help readers learn more about parasitic infections and how to effectively collect and prepare samples, aiding in the diagnosis of parasitosis. The subtle differences between similar parasitic organisms are all explained in a simple and easily understood manner, increasing the likelihood that readers will be able to recover the parasites, prepare them for identification and, subsequently, ensure effective treatment.

For more than four decades, Ganong's Review of Medical Physiology has been the leader in helping medical students and clinicians understand the fascinating subject of human and mammalian physiology. Concisely covering every important topic without sacrificing depth or readability, Ganong's delivers more detailed, clinically-relevant, high-yield information per page than any similar text or review. Thoroughly updated to reflect the latest research and developments in important areas such as the cellular basis of neurophysiology, Ganong's Review of Medical Physiology incorporates examples from clinical medicine throughout the chapters to illustrate important physiologic concepts. Whether you're a student who needs an outstanding review for the USMLE or a physician who wants to keep pace with the ever-changing field of medical physiology, there's no better place to turn than Ganong's Review of Medical Physiology.

This book is a comprehensive guide to the assessment and management of adults with thyroid disorders in daily clinical practice. All important aspects and disorders are considered. Relevant information on basic anatomy, embryology, immunology, and physiology is included to provide a better basis for understanding the development of disease and its diagnosis and treatment. Currently available biochemical tests and other specific diagnostic tools are also considered in detail. The various common thyroid disorders are then discussed in a series of individual chapters that focus on etiology, pathophysiology, symptomatology, diagnosis, and treatment. Numerous high-quality illustrations and concise fact boxes are included. The authors are all experts with wide experience in three disciplines and a long-standing interest in thyroid disease.

The largest-ever independent, laboratory-based evaluation of rapid diagnostic tests (RDTs) for malaria has shown that some tests on the market perform exceptionally well in tropical temperatures and can detect even low parasite densities in blood samples, while other tests were only able to detect the parasite at high parasite densities.

This document reports on evaluations co-sponsored by the WHO Regional Office for the Western Pacific (WPRO), WHO-based Special Programme for Research and Training in Tropical Diseases (TDR) and the Foundation for Innovative New Diagnostics (FIND). Testing was performed at the US Centers for Disease Control and Prevention (CDC). Forty-one commercially available RDTs went through a blinded laboratory evaluation.

The findings will serve as a tool for countries to make informed choices, from among the dozens of tests commercially available, on the purchase and use of rapid diagnostics that are best suited to local conditions.

This performance evaluation will also inform procurement and prioritization for diagnostic test entry into WHO Prequalification Diagnostics Programme and WHO Procurement Schemes. Donor agencies also regularly refer to WHO recommendations on diagnostics when making their own purchases.

Childhood brain tumors are a diverse group of diseases characterized by the abnormal growth of tissue contained within the skull. Other than leukemia and lymphoma, brain tumors are the most common type of neoplasms that occur in children. The leading cause of death from childhood neoplasms among persons up to 19 years is brain tumors. As such, this book is a review of the most recent molecular biological research concerning brain tumors with references and comparisons to a variety of neoplastic disorders. The book then uses this information to foreshadow the direction that future anti-neoplastic therapies will take. Because of the wide spectrum of the objectives of the book, any individual involved in cancer research will greatly benefit from the work. Histopathologists, neuropathologists, clinical and research oncologists, and medical students will find this book to be an invaluable resource as a reference guide. Patients and their families will also find the book useful as it offers a comprehensive update on new, non-classical therapeutic modality options and contains a detailed description and analysis of brain tumors. Such an endeavor has yet to be undertaken by any other book and may prove to be the most comprehensive book on brain tumors thus far.

Well-known and highly respected diabetes authority Ronald A. Codario, MD, details for busy primary care practitioners the state of the art in diagnosing and managing diabetes, as well as in reducing patient risk factors. Using an evidence-based approach, Dr. Codario explains, in simple clinical terms that avoid the complexity of much larger textbooks, our latest understanding of the pathophysiology of diabetes, its treatment with insulin and oral agents, and the management of its risk factors. The author also extensively reviews such major topics as the metabolic syndrome, the role of exercise and nutrition, and the key issues associated with the use of herbs and nutraceuticals. Also included are continuing medical education (CME) questions that provide the opportunity to acquire up to a maximum of 10 AMA/PRA category 1 CME credits. For the past 15 years, the author has given CME lectures on diabetes throughout the country.

Recent research in diabetes has proven Type 1 diabetes is no longer only a juvenile disease. It has been projected adult Type 1 diabetes will increase 40% from 1997-2010, and as our understanding of the pathogenesis of Type 1 and Type 2 diabetes grows - it is apparent that some cases previously classified as Type 2 are actually adult onset Type 1 diabetes. This volume is the first to focus exclusively on Type 1 diabetes in adults, seeks to clarify the complexities by explaining latest concepts in the pathophysiology and management of the disease, and to assist clinicians in the optimal utilization of cutting edge technology, therapeutics, and management strategies available to them.

This pocket-sized quick-reference handbook presents evidence-based recommendations for diagnosis and treatment of endocrine disorders. The authors summarize the latest and best clinical studies supporting the practice recommendations and grade each study to indicate the benefits and risks of the therapy and the reliability of the study results.

Chapters cover disorders in the major areas of endocrinology—hypothalamic-pituitary, thyroid, adrenal, metabolic bone, reproductive, diabetes, lipid disorders, obesity and nutrition, endocrine malignancies, and genetics. This thoroughly updated edition features a new chapter on genetics, expanded chapters on lipids and obesity and nutrition, and comprehensive coverage of new therapies for diabetes and osteoporosis.

Glycemic Control in the Hospitalized Patient: A Comprehensive Clinical Guide

Lillian F. Lien, Mary E. Cox, Mark N. Feinglos, and Leonor Corsino

ISBN-10: 1607610051

ISBN-13: 978-1607610052

Glycemic Control in the Hospitalized Patient: A Comprehensive Clinical Guide is a unique, practical resource for health care providers dealing with hyperglycemia in the inpatient setting. Outlining a hands-on approach used by the Duke University Inpatient Diabetes Management team, the book discusses a wide range of scenarios that occur while treating patients with hyperglycemia, including challenging circumstances such as steroids and tube feeding regimens. Special emphasis is given to insulin therapy. The chapters are written by a group of health care providers with extensive, pioneering experience in hyperglycemia control in the inpatient setting at the Duke University Medical Center. The book includes the most up-to-date scientific evidence and information and is addressed to not only hospitalists and general internists but also endocrinology fellows, residents, nurse practitioners, nurses, and other primary care practitioners who treat patients in the inpatient setting. The focus is clearly on practical, patient-care topics. Glycemic Control in the Hospitalized Patient: A Comprehensive Clinical Guide is a first-of-its kind, comprehensive guide to state-of-the-art inpatient glycemic management.

The twin epidemics of obesity and type 2 diabetes mellitus (T2DM) continue to affect an ever increasing number of children, adolescents, and young adults. Management of Pediatric Obesity and Diabetes provides healthcare trainees and professionals with practical, comprehensive, and contemporary approaches to the pediatric patient at risk for obesity, T2DM, and related conditions. A unique guide on the subject, this volume provides clinical paradigms for diagnosis and management of pediatric T2DM and related conditions, while succinctly describing state-of-the-art basic and clinical sciences underlying these problems. The chapters in this volume are independent and concise. Each chapter focuses on a key clinical issue or mechanism of disease. Providing practical, data-driven resources based upon the totality of the evidence, this important text helps the reader understand the basics of pediatric obesity and T2DM and implement strategies to prevent and treat obesity and diabetes in children and adolescents. Management of Pediatric Obesity and Diabetes provides health professionals across many areas of research and practice with up-to-date, well-referenced, and comprehensive evidence on identification, treatment, and prevention of these chronic, serious, metabolic diseases in children. This volume will serve the reader as the most authoritative resource in the field to date.

This book contains reviews and original articles with emphasis on pathogenesis and treatment of low back pain except for the rehabilitative aspect. Consisting of three sections, the first section of the book has a focus on pathogenesis of low back pain, while the second and third sections are on the treatment including conservative and surgical procedure, respectively.

Low back pain is a common disorder which affects the lumbar spine, and is associated with substantial morbidity for about 80% of the general population at some stages during their lives. Although low back pain usually is a self-limiting disorder that improves spontaneously over time, the etiology of low back pain is generally unknown and the diagnostic label, "non-specific low back pain", is frequently given.

ContentsPrefacePart 1 Pathogenesis1 Spinal Alignment and Low Back Pain Indicating Spine Shape Parameters2 Osteophyte Formation in the Lumber Spine and Relevance to Low Back Pain3 Low Back Pain and Injury in Athletes4 Relationship of Duration and Intensity of Pain with Depression and Functional Disability Among Patients with Low-Back Pain5 Psychosocial Risk Factors in the Development of LBP6 Evaluation and Management of Lower Back Pain in Oncological PatientsPart 2 Conservative Treatment7 Pharmacotherapy for Chronic Low Back Pain8 Application of Radiofrequency in Low Back Pain TreatmentPart 3 Surgical Treatment9 Nonfusion Techniques for Degenerative Lumbar Diseases Treatment10 Posterior Dynamic Stabilization: The Interspinous Spacer11 Development and Clinical Evaluation of Bioactive Implant for Interbody Fusion in the Treatment of Degenerative Lumbar Spine Disease12 Surgical Management of Low Back Pain and Degenerative Spinal Disorders

Written by leading teledermatologists and telemedicine experts, this hands-on guide addresses the practical needs of the many emerging teledermatology services worldwide. It covers the medical and technical prerequisites for such services as well as the photographic imaging essentials. It also illustrates the performance of teledermatology by means of clinical examples, discusses teledermatology in underdeveloped countries, and presents specialized methods of teledermatology. The impact of telemedicine on the doctor-patient relationship is explored, and the advantages that accrue from improving access to expert knowledge are explained. In addition, quality assurance, legal assumptions, economic aspects, and the future horizons of such health care services are all considered. A comprehensive appendix provides information on training opportunities, sample protocols, consent forms, information sheets, references, and relevant web links.

This book centralizes on the subject of contact dermatitis. It aims to provide the dermatologist with a sound base of clinical wisdom and key scientific findings to make an accurate diagnosis and management plan.

SPECIAL FEATURES: - Describes numerous possible allergens that cause contact dermatitis. - Provides details of research in the basic sciences to help our readers understand more about contact dermatitis.- Provides a comprehensive description of recently developed methods that have evolved for the diagnosis of contact dermatitis. - Provides a concise, clinically focused, user-friendly format, which can rapidly improve your knowledge of the disease.

ContentsPart 1 Epidemiology1 Epidemiology of Contact DermatitisPart 2 Pathogenesis2 Animal Models of Contact Dermatitis3 Keratinocytes, Innate Immunity and Allergic Contact Dermatitis - Opportunities for the Development of In Vitro Assays to Predict the Sensitizing Potential of ChemicalsPart 3 Patch Testing4 Allergens (Patch Test Studies) From the European Baseline Series5 Topical Delivery of Haptens: Methods of Modulation of the Cutaneous Permeability to Increase the Diagnosis of Allergic Contact Dermatitis6 Progress on the Development of Human In Vitro Assays for Assessment of the Sensitizing Potential of a Compound: Breaking Down the In Vivo EventsPart 4 Allergic Contact Dermatitis to Specific Allergens7 Dental Metal AllergyPart 5 Contact Dermatitis in Children8 Allergic Contact Dermatitis in Children9 Contact Dermatitis in Children

An invaluable work that will help dentists and oral surgeons to recognize and diagnose gross dental abnormalities. This book provides practically applicable knowledge on histology and histopathology of the changes that are seen in diseases of the dental and periodontal tissues. It includes the disturbances in tooth formation, acquired dental diseases including caries and its sequelae for the tooth-surrounding tissues, periodontal disease and odontogenic tumours. Also, attention is paid to the histological alterations induced by dental treatment.

Lippincott's Illustrated Reviews: Immunology is a brand-new addition to the internationally best-selling Lippincott's Illustrated Reviews Series. This volume offers a highly visual presentation of essential immunology material, with all the popular features of the series: over 300 full-color annotated illustrations, an outline format, chapter summaries, review questions, and case studies that link basic science to real-life clinical situations. Lippincott's Illustrated Reviews: Immunology can be used as a review text for a short immunology course, or paired with Lippincott's Illustrated Reviews: Microbiology for a combined microbiology/immunology course.

Now in full color, Lippincott's Illustrated Reviews: Microbiology, Second Edition enables rapid review and assimilation of large amounts of complex information about medical microbiology. The book has the hallmark features for which Lippincott's Illustrated Reviews volumes are so popular: an outline format, 450 full-color illustrations, end-of-chapter summaries, review questions, plus an entire section of clinical case studies with full-color illustrations.

This edition's medical/clinical focus has been sharpened to provide a high-yield review. Five additional case studies have been included, bringing the total to nineteen. Review questions have been reformatted to comply with USMLE Step 1 style, with clinical vignettes.

The Fifth Edition of Greenfield's Surgery has been thoroughly revised, updated, and refocused to conform to changes in surgical education and practice. Reflecting the increasingly clinical emphasis of residency programs, this edition features expanded coverage of clinical material and increased use of clinical algorithms. Key Points open each chapter, and icons in the text indicate where Key Points are fully discussed. Many of the black-and-white images from the previous edition have been replaced by full-color images.

This edition has new chapters on quality assessment, surgical education, and surgical processes in the hospital. Coverage of surgical subspecialty areas is more sharply focused on topics that are encountered by general surgeons and included in the current general surgery curriculum and ABSITE exam. The vascular section has been further consolidated. A new editor, Diane M. Simeone, MD, PhD, has joined the editorial team.

This book focuses on some of the latest technologies for the development of new immunoassays.

From the basic in vitro study of a specific biomolecule to the diagnosis or prognosis of a specific disease, one of the most widely used technology is immunoassays. By using a specific antibody to recognize the biomolecule of interest, relatively high specificity can be achieved by immunoassays, such that complex biofluids (e.g. serum, urine, etc.) can be analyzed directly.

In addition to the binding specificity, the other key features of immunoassays include relatively high sensitivity for the detection of antibody-antigen complexes, and a wide dynamic range for quantitation. Over the past decade, the development and applications of immunoassays have continued to grow

This handbook is an invaluable resource for improving the management of diabetes. Chapters cover the fundamentals, including epidemiology, history and physical examination, and functional evaluations. Diabetes in children, adolescents, adults, and geriatrics are addressed. Differential diagnosis is emphasized, and evidence-based guidelines and patient-specific considerations aid the reader with injury evaluation and care. Notably, the book highlights the importance of understanding diabetic symptoms when determining the source of illnesses. In addition, the text presents the spectrum of treatment options for diabetes. The book is complete with appendices that explain the evidence-based approach used throughout and the science behind therapeutic modalities.

The most common problems for which patients present to the Emergency Department are neurological disorders, including stroke, syncope, back pain and headache. The etiology of the patient's symptoms may be life-threatening, that is, when headache is due to subarachnoid hemorrhage or meningitis, or life-altering, that is, when back pain or weakness is due to spinal cord compression, if not diagnosed and treated urgently. This is a comprehensive textbook of the disorders that are neurological emergencies, including their differential diagnosis, diagnosis and treatment. Designed for any practitioner who makes time-sensitive decisions, Emergency Neurology is an indispensable, one-stop resource to aid your clinical decision-making.

This is the standard and definitive reference for virus taxonomy, generated by the ICTV approximately every 3 years. The VIII ICTV Virus Taxonomy Report provides information on 3 orders of viruses, 73 families, 9 subfamilies, 287 genera and 1938 virus species, illustrated by more than 429 pictures and diagrams, most of them in color.

* The standard official ITCV reference for virus taxonomy and nomenclature, compiling data from 500 international experts * Covers over 6000 recognized viruses, organized by family with diagrams of genome organization and virus replication cycle* Provides data on the phylogenic relationships between viruses belonging to the same or different taxa* Now includes information about the qualitative and quantitative relationships between virus sequences