SideQuesting asked Obsidian's Matt MacLean about the lack of a female protagonist as well as the lack of one of the most important RPG features: gay romances.

It looks like Agent Thorton’s sexual orientation is also set in stone, but for different reasons. We also asked MacLean about homosexual romance scenes. He told us that they wanted to make Alpha Protocol in such a way that would mimic what you would expect to see when you go see a spy flick. And since we never see James Bond or Jason Bourne get involved in homosexual scenes in their movies, players won’t have full freedom to choose how their sexual exploits go down.