A study from Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California 94305, USA; Paul F. Glenn Center for the Biology of Aging, Stanford University School of Medicine, Stanford, California 94305, USA Neuroscience Graduate Program, Stanford University School of Medicine, Stanford, California 94305, USA; Center for Tissue Regeneration, Repair and Restoration, V.A. Palo Alto Healthcare System, Palo Alto, California 94304, USA shows that “Human umbilical cord plasma proteins revitalize hippocampal function in aged mice.“ This research paper was published, in the 19 April 2017 issue of the journal “Nature” [One of the best research journals in General sciences with an I.F of 43+], by Prof. Wyss-Coray, Castellano JM and others.

What we say:

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: An olive oil way to enhance learning, memory, cognition and longevity: Oleic acid as a learning/memory/cognitive/longevity-enhancer: Oleic acid, isolated from olive oil and others, increases Tissue inhibitor of metalloproteinases 2 (TIMP2) levels, improves cognition, and decreases age-associated decline in memory and learning, via down regulation of its target genes

This study reveals, for the first time, an unknown action of a known oleic acid in learning/memory/cognitive-enhancement. Oleic acid, by increasing the expression of its target genes, may increase the levels of TIMP2. Thereby, it may: (1) increase the expression of genes that promote learning and memory; (2) cognition and learning; (3) improve spatial memory; and (4) promote hippocampal function (fig.1).

Figure1. Mechanistic insights into how oleic acid functions as a positive regulator of learning, cognition, memory and longevity. Oleic acid, by increasing the expression of TIMP2, it increases learning and memory in aged individuals

Thus, a pharmaceutical mixture encompassing oleic acid or its analogues, either alone or in combination with other drugs,“ may be used to suppress age-associated overall physiological decline of hippocampal function and improve cognition and memory (fig.2).