Abstract : Audio source separation models are typically evaluated using objective separation quality measures, but rigorous statistical methods have yet to be applied to the problem of model comparison. As a result, it can be difficult to establish whether or not reliable progress is being made during the development of new models. In this paper, we provide a hypothesis-driven statistical analysis of the results of the recent source separation SiSEC challenge involving twelve competing models tested on separation of voice and accompaniment from fifty pieces of - professionally produced - contemporary music. Using non-parametric statistics, we establish reliable evidence for meaningful conclusions about the performance of the various models.