An experimental dendritic vaccine has shown significant prognosis and ...Provenge carries the patients own dendritic cells engineered to expr...There are also questions about which cells are antigens to use in va...The provenge trial has raised several questions of its own: 34% of m...“Cancer vaccines prime the immune system to attack cancer a slower...

An experimental dendritic vaccine has shown significant prognosis and extension of lifetime of men with prostate cancer. The vaccine Provenge is based on dendritic cells, which help the immune system recognize tumors. // “If these results are true, this represents the first proof of principle of a dendritic cell vaccine altering the natural history of a solid tumor”, says Philip Kantoff, Chief of solid tumor oncology at the Dana-Farber Cancer Institute in Boston.

Provenge carries the patients own dendritic cells engineered to express a protein found on about 95% of prostate cancer cells. It is one of more than 15 vaccines in trials for a range of cancers, including lymphoma, melanoma, breast, lung and colorectal cancers, but the first to increase lifespan in advancer cancer patients.

There are also questions about which cells are antigens to use in vaccines and the mode and frequency with which they should be administered. For example, mature dendritic cell vaccines seem to produce the best immune response when given either subcutaneously or intradermally, but not intravenously. Researchers are trying to determine whether vaccines will be need to be designed for specific cancers, or whether a universal vaccine could produce a robust immune response.

The provenge trial has raised several questions of its own: 34% of men given provenge, compared with 11% on placebo, were alive three years on, and lived 4.5 months on average longer. “Because of this, we were all somewhat pleasantly surprised that Provenge showed a survival benefit, says E. Roy Berger, director of the Prostate Cancer Consultation and Treatment service in East Setauket, New York.

“Cancer vaccines prime the immune system to attack cancer, a slower, more indirect process,’ he says. This may mean that survival, and not time to progression is a better measure of efficacy for cancer vaccines, Berger suggests.

(Date:7/31/2015)... ... August 01, 2015 , ... Super Bowl 50 will emanate from Levi’s Stadium in ... each year is the Super Bowl. In the two weeks that separate the conference championships ... venue. The 2016 Super Bowl game will mark the 50th time it has been held ...

(Date:7/31/2015)... (PRWEB) , ... July 31, 2015 , ... ... its new store run by GoodThreads. The store can be accessed by visiting ... designs, many of which are customizable. The best part: whenever a product is ...

(Date:7/31/2015)... ... July 31, 2015 , ... Jacksonville-based drug ... new True North Conference Center. The medical community, social workers, law enforcement, and ... be more aligned in the effort to better understand and combat sex trafficking. ...

... out the noise of the dental drill could spell the ... to experts at King,s College London, Brunel University and London ... is widely known that the sound of the dental drill ... some patients avoid trips to the dentist because of it. ...

... HealthDay Reporter , FRIDAY, Jan. 7 (HealthDay News) ... fluoride in the nation,s drinking water should now be set ... significant help in preventing cavities and tooth decay, too much ... two out of five teens have white spots and streaks ...

... News) -- The hand gestures you use while talking can ... researchers had volunteers solve a puzzle called the Tower of ... to another. After completing the task the participants talked about ... of hand gestures. The participants then tried the problem ...

... , FRIDAY, Jan. 7 (HealthDay News) -- Adolescents ... and "explosive strength" than those who were not breast-fed, ... parents of 2,567 adolescents about the type of feeding ... the muscular strength and aerobic abilities of the adolescents. ...

... , THURSDAY, Jan. 6 (HealthDay News) -- Among ... of human papillomavirus from men to women, according to ... protection and partners must still practice safe sex, the ... sexually transmitted infection that puts women at risk for ...

... the origin of brain tumors known as oligodendrogliomas, which are a ... type of malignant brain tumor. In a paper published in ... investigators found that the tumor originates in and spreads through cells ... to as "daughter" cells of stem cells. The work comes at ...

(Date:7/31/2015)... , July 31, 2015 More than ... the country will convene in Indianapolis ... (CADCA),s 2015 Mid-Year Training Institute . The week-long ... how to address one of our nation,s biggest public ... CADCA,s Mid-Year Training Institute is a one-of-a-kind intensive training ...

... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...

... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...

... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...

... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...