Hypoglycorrhachia with Meningeal Carcinomatosis: Report of Two Cases

Abstract

In recent years attention has been called to the fact that cerebrospinal fluid glucose may be extremely low and of diagnostic importance in conditions other than the infectious meningitides. Although hypoglycorrhachia was described in 1904 in a case of carcinomatosis of the meninges without infection (1), this phenomenon received little or no attention in the English literature until 1952 when Dodge, Sayre, and Svien (2) reported four cases with metastatic carcinoma in which the metastases involved the meninges and there was associated low cerebrospinal fluid (CSF) glucose. Subsequently, Berg (3) reported five cases of his own, and at that time