MADRID (AP) - If beating Atletico Madrid wasn’t hard enough for Real Madrid, the defending champions must now find a way to better their crosstown rivals in the Champions League without four of their most important players.

A depleted Madrid hosts Atletico on Wednesday in the second leg of the quarterfinals. Their 0-0 draw last week means that the fitter and more physical Atletico can advance with either a win or a draw with goals.

Madrid has yet to beat Atletico in seven matches this season in four competitions and now faces overcoming a spate of injuries that has sidelined Gareth Bale, Karim Benzema and Luka Modric. Marcelo is suspended.

However, Atletico midfielder Jorge “Koke” Resurreccion is still wary of a Madrid side featuring Cristiano Ronaldo.

“Madrid has a great team whoever plays, that’s why it’s Real Madrid,” Koke said. “In the end, we are still 11 against 11 and we don’t care who plays. Our job is to win the tie.”

Here are some things to know about the match:

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MANGLED MADRID

Madrid coach Carlo Ancelotti was already busy figuring out a way to finally beat Atletico this season. But now that three of his players have been ruled out in the space of three days, he has the additional problem of choosing his starting 11.

Modric was diagnosed with a sprain to a right-knee ligament on Sunday. The next day doctors said Bale had hurt his left calf, and that was followed by Benzema being diagnosed with a right-knee sprain of his own on Tuesday.

Ancelotti plans to use Fabio Coentrao in place of Marcelo. He could opt to deploy two playmakers in Francisco “Isco” Alarcon and James Rodriguez in place of Bale, leaving Ronaldo up front with either the little-used Javier Hernandez or Jese Rodriguez.

Ancelotti said he “would field the best team to win the game.”

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DOWN TO THIS

Atletico is one match away from avenging last season’s painful 4-1 extra time loss to Madrid in the Champions League final.

And while Madrid can still vie for the Spanish league title, trailing Barcelona by two points with six matches to go, Atletico’s hopes of winning a major trophy for a fourth consecutive season under coach Diego Simeone hinge on advancing to the semifinals.

“I am facing it like it’s the most important game of the season,” Atletico’s Fernando Torres said.

Atletico has not lost in its last three visits to the Bernabeu.

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RONALDO & RODRIGUEZ

Despite its injuries, Madrid will still have the Ballon d’Or winner to count on.

Ronaldo reached the 50-goal mark for the fifth consecutive season in Madrid’s 3-1 win over Malaga, which also saw Rodriguez match his best scoring tally of his career with his 14th goal of the campaign.

Rodriguez immediately became a first-choice player for Ancelotti after joining the club, and he has shown no lack of form since returning recently from a fracture in his right foot.

“For Bale and Benzema we have various solutions, which include Chicharito (Hernandez) and James, who is in great form right now and can play on the right side or in the middle,” Ancelotti said. “He helps us a lot with his ability to assist and to arrive to the area and score goals.”

Madrid has scored in its last 22 Champions League home games, a four-year run.

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GUNNING GRIEZMANN

Atletico is known for excelling at set pieces, but Antoine Griezmann is now leading its attack with his speed and ability to elude defenders in the area.

The France forward leads the team with 23 goals and has scored six times in his last five appearances.

“He has grown so much and his goals are the proof,” Simeone said. “He is young and has to keep growing and improving. I hope he can show he is doing so each day.”

Striker Mario Mandzukic, Atletico’s other main threat with 20 goals, has been slowed by an ankle injury but is expected to be available.