Brookland–CUA station is slated to be the center of a massive transport-oriented regeneration with the aim of increasing pedestrian-friendly development and an arts-focused neighborhood.[3] The project includes a relocation of the station portals slightly to the south in a plaza with the western end of 9th, Newton, and Otis Streets which will be extended to the station plaza for more convenient access to the rest of the surrounding area.[3]

In August 2014, Metro picked a joint venture involving MRP Realty and CAS Riegler LLC to begin the redevelopment of the 1.8 acres (7,300 m2) site. The plan called for construction of 280 apartments and condominiums; 9,000 square feet (840 m2) of ground-floor retail, 228 parking spaces, and the replacement of Metro's 38-space Kiss & Ride lot. Metro proposed a 98-year lease that included rent increases, and required the joint venture to seek approval of its plans from the District of Columbia Zoning Commission. At that time, Metro said ground would break on the redevelopment in 2016.[4]

But in January 2015, the joint venture said it would take at least four years before it could complete its plans and obtain zoning commission approval, and that it would not be able to sign a lease until 2019.[4]

Originally simply known as "Brookland," in 1979 its name was changed to "Brookland–CUA" due to the proximity of The Catholic University of America to the station.[5] An unusual feature of this station is that the platform is slightly curved, requiring mirrors to be placed on the westbound side of the platform, to aid train operators in making sure the area is clear before closing the doors.

In addition, Brookland–CUA also has a relatively uncommon layout; passengers entering the station first take escalators, stairs, or an elevator down to a lower level which includes the station's faregates and kiosk, then use escalators or elevators to go back up to reach the platform level.