Program Scope and Mission – Research opportunities available to trainees cover a broad range of basic and clinical research subjects relevant to transfusion medicine and hematology; including; Immunology, Vascular Biology/Hemostasis, Transfusion Medicine, Stem Cell Biology, and Clinical Research. The research training experience will be essentially full time. Trainees will be expected to gain a basic understanding of the disciplines in which they undertake their investigations, develop competency with a variety of research technologies, strengthen their grasp of their chosen research by taking selected courses in the graduate studies program of Medical College of Wisconsin, and develop the ability to conduct independent research. Time spent in fellowship training is regarded as one of several stages of professional development. Accordingly, additional tracks will be offered to selected trainees including; the opportunity 1) to apply for a Clinical Investigator Development Award (K08) for continued mentoring, 2) to apply for independent grant support, and 3) for those oriented toward a career in transfusion medicine, an opportunity for further training as a junior member of BloodCenter's medical staff. Ultimately, trainees are expected to pursue academic or alternate careers in transfusion medicine, hematology, or closely related fields.

Translational GlycOmics K12 Program –Blood Research Institute

Director:Karin Hoffmeister, M.D.Senior Investigator Blood Research InstituteProfessor of Biochemistry at Medical College of WisconsinAssociate Professor of Pediatrics, Harvard Medical School Email: This email address is being protected from spambots. You need JavaScript enabled to view it.

Program Scope and Mission – Translational medicine fosters cross-functional collaborations between researchers and clinicians to facilitate new and precision-driven treatments for individualized therapy. While scientists and clinicians successfully applied this approach to four fundamental building blocks of life (nucleic acids, lipids, proteins and carbohydrates), the science of glycans (carbohydrates) has received the least attention. The diverse functions of glycans contribute to the structural integrity of biomolecules, extracellular matrix formation, signal transduction, protein folding, information exchange between cells, and host-pathogen interactions. Despite their functional diversity and specificity, carbohydrates are commonly associated with weight gain and diabetes while their major contributions to health and disease remain vastly understudied. Furthermore, the use and modulation of glycans has been largely unexplored in therapeutic strategies. There is an urgent need to support and educate glycoscientists concomitantly with the biology of human health and disease, thus enabling clinicians and glycoscientists to recognize medical needs and therapeutic opportunities. To meet these needs, the National Heart, Lung, and Blood Institute (NHLBI) for the first time has offered a K12 Career Development Program in translational glycosciences titled “National Career Development Consortium for Excellence in Glycosciences.”

One of the four national sites is the Blood Research Institute and the Center for Translational Glycomics, BloodCenter of Wisconsin (BCW), in association with the Medical College of Wisconsin (MCW), Roswell Park Comprehensive Cancer Center (Roswell), and Virginia Commonwealth University (VCU). This program, The Medical and Translational GlycOmics Program (Translational GlycO Program), is a multi-institution (Wisconsin, New York and Virginia) program, linking unique and diverse glycoscience expertise with research facilities, major teaching hospitals, blood banking and pharmaceutical education. It is expected that the Translational GlycO Scholars will commit to and pursue a glycoscience based investigation, as it relates to the mission of the NHLBI (heart, blood, lung, and sleep disorders). Training in investigative glycoscience thought processes and experimental tools will be provided through a rigorous program involving hands-on research, didactic coursework, collaboration with experienced scientists in and outside the field, dissemination of knowledge, paper and grant writing activities, and participation in the national K12 consortium. Scholars will become knowledgeable in 1) molecular aspects of glycoscience; 2) experimental research inquiries into functions of glycans; 3) translation of bench research to the bedside; 4) dissemination of research to scientists and the lay public; and 4) writing extramurally funded grant applications. For more information and application processes refer to the K12 Program Website

Program Scope and Mission – This five year T32 program is one of only six post-doctoral T32 training programs on the Milwaukee Medical Regional Campus. The grant provides up to three-years of training for post-doctoral fellows with an MD, PhD, PharmD, or DO degree (two new slots/year). Forty-six basic scientists and translational investigators serve as mentors in a program that is supported by specific research areas of scientific excellence (“Signature Programs”), a highly-integrated collaborative research environment, and access to an extensive research infrastructure.

This three-year training commitment emphasizes critical components designed to launch/sustain research careers: • Individualized development plans (IDPs), • Personalized multidisciplinary mentoring teams, • Training in core competencies, and • Industry/biotechnology or scientific liaison career options for trainees not pursuing a traditional career in academia. Overall, the ultimate goal of this training program is to train the next generation of cardiovascular scientists, including underrepresented minorities, by incorporating broad-based, personalized, supportive, and rigorous training opportunities. Additional support for trainees is provided by a grant from the A. O. Smith Foundation for the Cardiovascular Center’s A. O. Smith Fellowship Scholars Program. This unique program is designed to support talented cardiovascular researchers and physicians in an innovative educational program that aims to provide mentoring, training, research support, and the necessary resources to overcome the barriers that exist to launching and sustaining a successful research career.

Program Scope and Mission – The NIH-funded Vascular Surgery Scientist Training Program at Northwestern University is a two-year mentored research training program designed for surgical residents (MD/DO) in general and vascular surgery and for PhD postdoctoral research fellows interested in vascular biology or vascular biomedical engineering careers. Our goal is to provide a seamless multidisciplinary environment in which the trainee may interact with a diverse group of distinguished research faculty. The T32 mechanism provides a stipend, tuition, fees for coursework, travel funds, and health insurance.

The key to this program is an individualized training plan developed by the mentor and trainee. The unique multidisciplinary environment provides trainees with opportunities to work with mentors from different disciplines. The goal of this program is to match the research interest of the trainee to mentors, coursework, seminars, meetings, and a research plan that will collectively provide the experience necessary to launch a successful career as a physician scientist. Trainees may select one of several tracks of study or a combination of tracks: • Vascular biology with a basic science or translational emphasis, • Clinical outcomes/health services research • Biomedical devices in partnership with the Biomedical Engineering Department, • An integrated program designed by the trainee and his/her mentors. Trainees who select the clinical outcomes/health services research track will pursue the Master of Science in Health Services and Outcomes Research degree program at NU. We are currently recruiting for the positions that start on July 1, 2019. Candidates must hold either an MD, DO, or PhD degree. MD/DO candidates must have completed at least two years of clinical training prior to enrolling in the program. Candidates must be U.S. citizens, noncitizen nationals, or have been lawfully admitted for permanent residence at the time of appointment. Minorities and women are encouraged to apply. Applicants will submit a written application along with three letters of recommendation.

Contact:Dr. Brenda Lilly This email address is being protected from spambots. You need JavaScript enabled to view it.andDr. Vidu GargThis email address is being protected from spambots. You need JavaScript enabled to view it.

Program Scope and Mission – A postdoctoral fellow position is available for the T32 Fellowship Program entitled, “Training in Congenital and Acquired Heart Disease.” The program is jointly hosted by the Research Institute at Nationwide Children’s Hospital and the Dorothy M. Davis Heart and Lung Research Institute at The Ohio State University (PIs: Dr. Vidu Garg and Dr. Peter Mohler).

Eligibility requirements are as follows: • MD, PhD, MD/PhD, DO, DVM, or PharmD, particularly underrepresented minorities, are encouraged to apply. Applicants will receive stipend (at appropriate NIH stipend guidelines), benefits and tuition support. • Applicant must be a citizen or a non-citizen national of the United States or have been lawfully admitted for permanent residence at the time of appointment. • Proposed research must be directly related to aspects of congenital or acquired cardiovascular disease and can be basic, translational, clinical or outcomes research. • 1 year fellowship that is renewed based upon productivity (for a maximum of 2 years). • Applicants are required to participate in the T32-developed curriculum (i.e. didactic coursework, seminars and/or journal clubs). • Applications are scored in 3 areas: trainee qualifications, scientific merit and training potential.

Program Scope and Mission – The Cardiovascular Training Grant supports both post-doctoral (M.D. and Ph.D.) and pre-doctoral (Ph.D.) students for terms of 2-3 years to work in the laboratories of one of 33 trainers, whose research is in the cardiovascular sciences. The trainers include faculty from Cardiology, Pathology, Internal Medicine, Neurology, Pharmacology and Physiology, and Biochemistry and Molecular Biology. The program emphasizes training in vascular biology, atherosclerosis, cardiac development, cellular electrophysiology, cellular metabolism, cell signaling, gene regulation, and genetic disease.

Understanding Cardiovascular Disease Mechanisms - The University of Cincinnati and Children’s Hospital

Program Scope and Mission – The University of Cincinnati and Children’s Hospital is carrying on a proud tradition of excellence in cardiovascular research and mentorship, which began 35 years ago under Dr Arnold Schwartz as one of the longest training programs in cardiovascular. Our current collective 19 faculty has placed 297 of their past trainees into academics over their careers, 154 of whom have run, or currently run independent research programs. The overall scientific emphasis of our training program will continue to build from a basic platform of cardiovascular physiology, cell biology, biochemistry and pharmacology, but will also incorporate the latest approaches in the post genomic era, as well as incorporating clinical and translational approaches. The cardiovascular environment at Cincinnati Children's and the University of Cincinnati is considered one of the very best in the country, with 19 NIH funded faculty (some 49 NIH grants amongst them as PI status), 166 collaborative papers published in 10 years, and the very latest technologies and approaches with outstanding core support. The leadership consists of the co-PIs Drs. Evangelia Kranias and Jeffery D. Molkentin, both of whom have a long standing track record of working closely together (15 years), as well as having excellent mentorship credentials. The training grant funds 3 pre- and 3 postdoctoral trainees. Predocs are selected by the Internal Advisory Committee from a wide pool arising from departmental graduate programs, while postdoctoral candidates are selected based on being accepted into a mentor's laboratory and then passing the screening process by the Internal Advisory Committee and co-PIs. The training program also has an educational core where both pre-docs and post-docs take elective classes in cardiovascular biology, genetics, statistics, grant writing and ethics in research. More importantly, the cardiovascular training faculty at the University of Cincinnati and Children’s Hospital is one of the largest groups in the nation and they incorporate the very latest technologies in the pursuit of their scientific endeavors. Strengths include generation of transgenic and gene-targeted mice, as well as CRISPR-mediated mouse production, in the pursuit of understanding single gene function in complex cardiovascular diseases. Genetics are also employed and the program also has a strong clinical mentorship track for trainees interested in translational science.

Lung and Vascular Biology and Pathobiology - University of Illinois at Chicago

PI/Program Director:Asrar B. Malik PhD

Contact:Dr. Asrar B. Malik Director of Center for Lung and Vascular Biology University of Illinois College of MedicineDepartment of Pharmacology835 South Wolcott Ave, E403 MSBChicago, IL 60612Phone: 312 996-5672Email: This email address is being protected from spambots. You need JavaScript enabled to view it.http://mcph.uic.edu/lungt32/

Program Scope and Mission – The NIH-funded UIC vascular biology training program is currently in its 25th year, providing comprehensive and cutting-edge training in vascular biology. Research topics include mechanisms of vascular regeneration, the use of stem cell therapies in vascular disease, the critical role of the vasculature in inflammation and immunity, modeling inherited vascular diseases with induced pluripotent stem cells, vascular biology of cancer, mechanisms of thrombosis and novel therapeutic anti-thrombotics. Our post-docs and PhD students are trained in using state-of-the art technologies such as intravital two-photon microscopy, super-resolution microscopy, protein engineering, high throughput small molecule screening or single cell transcriptomics. The training involves acquiring a range of skills from critical thinking and developing an innovative, testable hypothesis to deploying and utilizing relevant methods and technologies. We also offer opportunities to learn how to best communicate ideas and results through presentations and manuscripts. The success of our trainees is evident from their publication records in top tier journals and their current positions in academia and industry.

We have 40 preceptors participating in the training program who exhibit a breadth of scientific expertise ranging from basic cell biology to translational models of vascular disease. The faculty comprises a cohort of exceptionally talented mentors with a commitment to research training, collaboration, and developing careers of young investigators. These trainees and faculty meet regularly at the weekly vascular biology seminar as well as additional departmental seminars with invited speakers, many of whom are renowned leaders in the field of vascular biology. The program has several defining features that: · contemporary biomedical research training must be underpinned by collaboration that can be local or international, · research training is driven by fundamental ideas, and · solving important scientific problems and research training should be such as to provide a variety of opportunities beyond the training phase. The research training program provides opportunities for exposure to scientific leaders and role models and the intellectual environment of Chicago. It is our view that nurturing curiosity is a fundamental aspect of research training but that it also involves learning to ask important questions and becoming a well-rounded and humane individual.

Co-Director:Jan Kitajewski, PhDEmail: This email address is being protected from spambots. You need JavaScript enabled to view it.

Co-Director:Kishore Wary, PhDEmail: This email address is being protected from spambots. You need JavaScript enabled to view it.

Contact:Kamil Czarnowski, MPA Director of Administrative Operations Physiology and Biophysics College of Medicine University of Illinois at Chicago835 South Wolcott AveRoom E-231 MSB Chicago, IL 60612Phone: 312-996-3836Email: This email address is being protected from spambots. You need JavaScript enabled to view it.Web: https://physiology.uic.edu/training/

Program Scope and Mission – The NIH-funded Vascular Biology, Signaling and Therapeutics (VBST) training program is designed to be interdisciplinary, drawing on institutional expertise in four themes: Angiogenesis & Regeneration, Vascular Signaling, Neurovascular Biology and Vascular Therapeutics. VBST is made up of twenty-six (26) mentors, of which nine (9) are physician-scientists. This training program utilizes expertise within and interactions between the themes to train predoctoral and postdoctoral applicants in an integrative fashion.

VBST strives to meet an imperative need to train exceptionally talented and diverse scientists engaged in interdisciplinary vascular research with translational potential. The program’s aims are to assure that trainees understand the human vascular system, and are thereby poised to advance translational opportunities, reduce vascular disease, and bridge the current gaps in knowledge between discovery research, drug development and therapy.

Research Training in CVD Epidemiology and Prevention – University of Illinois College of Medicine

Program Scope and Mission – This Training Program is designed to prepare the next generation of scientists to conduct research in the epidemiology and prevention of cardiovascular disease (CVD) and related chronic diseases in minority populations. Despite decades of research progress, the burden of CVD and related chronic diseases in the United States remains high. Moreover, there are persistent race/ethnic disparities in CVD and other chronic disease outcomes. The goal of this program is to generate a talented and well-trained group of pre- and post-doctoral (MD and PhD) researchers to improve understanding of the etiology and prevention of CVD and related chronic conditions in minority populations and to alleviate race/ethnic disparities in CVD and related chronic disease outcomes.

Cardiovascular Institutional Research Fellowship – University of Iowa Carver College of Medicine

Director:Francois M. Abboud, M.D. Edith King Pearson Chair of Cardiovascular Research Associate Vice President for Research Chair Emeritus, Department of Internal MedicineFounding Director, Francois M. Abboud Cardiovascular Research CenterProfessor of Internal Medicine – Cardiovascular MedicineProfessor of Molecular Physiology and Biophysics Email: This email address is being protected from spambots. You need JavaScript enabled to view it.https://medicine.uiowa.edu/internalmedicine/profile/francois-abboud

Program Scope and Mission – The discovery of the causes of cardiovascular disease and their prevention; the care of the suffering patients and their cure, requires dedicated physicians and scientists to devote their lifelong work to a health mission without which a civilized society would not survive. Such individuals require years of training in medical science beyond their professional degree under the tutelage and mentoring of established senior medical investigators/teachers working in an environment with exceptional intellectual, technical, and physical resources. At the University of Iowa Cardiovascular Research Center, we have provided a world-renowned training center since 1975, have graduated hundreds of scientists, many of whom are national leaders throughout the USA, and aim to continue to do so for future generations with the renewal of federal support that we are applying for and hope to attain.

Program Scope and Mission – While the rate of deaths from cardiovascular disease (CVD) has been on the decline, improved survival has resulted in significant new cases and cost to the health care system in our rapidly aging society. Thus the goal of CVD epidemiology is to investigate and promote cardiovascular health, and to prevent and reduce CVD.

Traditionally, cardiovascular disease epidemiology has been concerned with causes of heart disease. In recent years, prevention by modification of lifestyle and behavior have been tested and found very effective. In addition, new methods to detect disease while subclinical have strengthened our studies of antecedent risk factors. Researchers at EpiCH investigate the distribution and causes of CVD and study the influence of: • high blood cholesterol • diabetes • high blood pressure • blood clotting • menopause • genetic variants • obesity and weight gain • fat distribution/ patterning They also explore the impact of health behaviors such as: • smoking • diet • physical inactivity • psychosocial stressors • education • geocoding and neighborhoods

Postdoctoral Fellowship Training Program in Cardiovascular Outcomes Research - University of Missouri-Kansas City

Program Scope and Mission – Applications are invited for a 2-year postdoctoral training program in cardiovascular outcomes research to begin July 1, 2018. This T32 training program, funded by the National Heart Lung and Blood Institute to the University of Missouri-Kansas City (UMKC), is hosted by Saint Luke’s Mid America Heart Institute (SLMAHI) in close collaboration with the University of Kansas.

The Full-Time Training Program offers: • Advanced seminars of specialized skills for Outcomes Research • Opportunity to obtain an MS in Bioinformatics with an emphasis in Clinical Research for those without prior formal training in the field • Multidisciplinary mentorship, individualized to meet the needs of each Fellow • Hands-on research experiences with access to highly experienced statisticians and numerous databases including multicenter outcome registries (e.g., PREMIER, TRIUMPH, PORTRAIT, PRISM, OPEN CTO, OPTIMUM), clinical trial databases (e.g., PARTNER, FREEDOM, SYNTAX), national quality databases (e.g., ACC’s National Cardiovascular Data Registries, AHA’s National Registry of Cardiopulmonary Resuscitation) and publically available clinical trial and observational data sets. • Salaried position based on NIH postdoctoral stipend scales • Insurance benefits, vacation time, tuition (for MS coursework), and funds for travel expenses to professional conference(s)

University of Wisconsin Vascular Research Training Program

Director: Jon Matsumura, MDEmail: This email address is being protected from spambots. You need JavaScript enabled to view it.

Program Scope and Mission – The University of Wisconsin Vascular Surgery Research Training Program is a multidisciplinary and collaborative program that will co-train young physician/surgeons who have chosen to be vascular specialists, along with PhD scientists who have a research interest in vascular disease. This NIH-funded program provides trainees with multiple opportunities for research activities in vascular-related research disciplines in order to foster the development of knowledge, skill, and experience for success in the future academic careers of our trainees. Our goal is to accelerate the performance of basic, translational and clinical research for vascular disease by producing future surgeons, scientists and engineers who will meet the great need for innovation in treatments for the growing population of patients.

Molecular and Cellular Pharmacology Training Program - University of Wisconsin-Madison

Director:Dr. Anjon Audhya Molecular and Cellular Pharmacology School of Medicine and Public Health5214a Biochemistry420 Henry MallMadison, WI 53706Phone: (608) 262-3761Email: This email address is being protected from spambots. You need JavaScript enabled to view it.

Program Scope and Mission – Pharmacology is the knowledge of the biochemical and physiological actions of drugs, which act on cellular signaling pathways. The molecular basis of cellular signaling and its control by various drugs is a major aspect of modern pharmacology and this aspect is emphasized in the Molecular and Cellular Pharmacology Training Program. The majority of signal transduction pathways still await discovery or at least a thorough molecular characterization. Members of our program employ the whole spectrum of modern biochemical, cell and molecular biological, physiological, and pharmacological methods in a basic research-oriented scientific environment to unravel the many unsolved mysteries underlying cellular regulation and signaling. Certain research initiatives have a translational component, with the goal of applying basic discoveries to developing new therapeutic modalities. Our program brings together an outstanding group of over 70 dedicated trainers with a focus on cellular signal transduction. Graduates of the program will be well prepared for a career in basic biomedical sciences in academia, industry, and more. We provide a unique training experience for young scientists who want to elucidate basic principles of cellular signal pathways. Detailed knowledge of these pathways is the most important prerequisite for the discovery of new drugs and the treatment of diseases. The members of the Molecular and Cellular Pharmacology Training Program invite you to examine the educational and research opportunities described on our website, and to consider joining this unique and exciting graduate program.

Research Training in Hematology – University of Wisconsin School of Medicine and Public Health

Program Scope and Mission – Our grant emphasizes pre-doctoral and post-doctoral training in the areas of vascular biology, and hematopoietic stem cells and malignancy. Vascular biology is critically important for human disease, impacting on basic processes such as inflammation, the immune response, hemostasis, thrombosis, and metastasis.

We have assembled a broad array of expertise in cellular and molecular aspects of hemostasis, extracellular matrix biology, vasculogenesis/angiogenesis, cellular mechanisms of inflammation, the genetics of diabetes, lipoprotein metabolism, and clinical aspects if hemophilic and thrombophilic states. Likewise, hematopoietic stem cells are important to therapeutic approaches in a variety of disease states, and the University of Wisconsin is an internationally recognized leader in embryonic stem cell biology. The participating investigators have expertise in the biology and hematopoietic differentiation of embryonic stem cells, chromatin modifications in hematopoiesis and leukemogenesis, intracellular signaling in myeloma, clinical trials in lymphoma, bone marrow transplantation, and clinical applications of embryonic stem cells in vascular and malignant disease. There is a strong emphasis on providing the multidisciplinary training required to pursue translational research opportunities, and the formal training of clinical investigators. Our training program takes advantage of the Clinical Investigator Preparatory Program (K30 grant) at the University of Wisconsin to provide didactic training in clinical trial design and biostatistics for candidates pursuing translational research projects.

Detroit Cardiovascular Training Program - Wayne State University

Director:Jian-Ping Jin, M.D., Ph.D. Professor & William D. Traitel Endowed ChairWayne state University School of MedicineDepartment of Physiology Email: This email address is being protected from spambots. You need JavaScript enabled to view it.

Program Scope and Mission – Cardiovascular disease is a leading cause of mortality in the United States. Understanding the physiology and pathology of the heart and circulation is the foundation for improving the treatment and prevention of cardiovascular diseases. The Detroit Cardiovascular Training Program (DCTP) was the first NIH-supported predoctoral training program in the region to provide research training for PhD graduate students in integrative and translational cardiovascular sciences. This training effort is contributing to the education of a new generation of scientists who will not only pursue cardiovascular research to improve health care, but also strengthen our economic base by innovations that will be translated to medical practice.

The DCTP has assembled an leading group of researchers from multiple departments such has Physiology, Biomedical Engineering, and Pharmaceutical Sciences, who provide expertise and research opportunities to trainees that range from molecular, cellular and organ levels to clinic research. In addition, Wayne State University has an outstanding track record of providing extensive training in the cardiovascular sciences and an exceptional record in the training of minority students in the Detroit metropolitan area, contributing a major role in research education in the region.

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