Corneal ulcersSolution Day 1: 2 drops in affected eye every 15 min for 6 h, then 2 drops every 30 min for remainder of day 1. Day 2: 2 drops every hour. Days 3 through 14: 2 drops every 4 h. May continue treatment after 14 days if corneal re-epithelialization has not occurred.

ConjunctivitisOintment Apply half-inch ribbon into conjunctival sac 3 times daily for the first 2 days, then twice daily for the next 5 days. Solution 1 to 2 drops every 2 h while awake for 2 days, then 1 to 2 drops every 4 h while awake for 5 days.

Children 1 to 17 yr of age:PO 10 to 20 mg/kg immediate-release tablet every 12 h (max, 750 mg/dose, even in patients weighing more than 51 kg) or IV 6 to 10 mg/kg every 8 h (max, 400 mg/dose, even in patients weighing more than 51 kg) for 10 to 21 days.

Renal Function Impairment

Adults:

PO:

Immediate-release/oral suspension: Usual dosage for CrCl more than 50 mL/min; 250 to 500 mg every 12 h for CrCl 30 to 50 mL/min; 250 to 500 mg every 18 h for CrCl 5 to 29 mL/min; 250 to 500 mg every 24 h (after dialysis) for patients on peritoneal or hemodialysis.

ER: Usual dosage for patients receiving 500 mg; for CrCl less than 30 mL/min, max dose is 500 mg every 24 h. For patients on dialysis, administer dose after dialysis procedure is complete.

XR: No dosage adjustment is needed for patients with mild to moderate renal impairment.

IV: Usual dosage for CrCl more than 30 mL/min; 200 to 400 mg every 18 to 24 h for CrCl 5 to 29 mL/min.

Conversion of IV to Oral Dosing With Immediate-Release Tablets or Suspension in Adults