(A) A total of 23 agents were identified by both DrugBank and Connectivity Map, with 13 having therapeutic potential as inferred from negative drug-disease score (p<0.05). Oxymetazoline (p<0.01) was a top 15 drug. (B) The predicted targets of oxymetazoline included upstream regulators including IFIH1 and STAT1, known regulators of interferon signaling.