The microRNA pathway in translational regulation of neuronal development

Several mental disorders are closely associated with defects during neuronal development in early life. Abnormalities in neuronal differentiation and synaptogenesis may contribute to fragile X syndrome, Rett syndrome, autism, and other mental disorders. Post-transcriptional regulation by tiny RNAs, called microRNAs (miRNAs), has emerged as an important mechanism for controlling gene expression in animal development; however, the exact functions of miRNAs in neuronal differentiation and function are poorly understood. In this proposal, investigators will use fruit flies to study the roles of microRNAs in the development of the nervous system. The proposed studies will provide important novel insights into the neuronal functions of the miRNA pathway in intact animal models and will further understanding of human mental disorders. These findings may also help develop new avenues for therapeutic interventions for these devastating illnesses.