anti-Mediator of Cell Motility 1 (MEMO1) Antibodies

May control cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton. Additionally we are shipping MEMO1 Proteins (10) and MEMO1 Kits (5) and many more products for this protein.

Biochemical assays revealed that Memo is a copper-dependent redox enzyme that promoted a more oxidized intracellular milieu and stimulated the production of reactive oxygen species (ROS (show ROS1 Antibodies)) in cellular structures involved in migration.

Memo1 showed robust expression in the perichondrium and periosteum of the developing cranial base, but only modest expression in the palatal shelves. Neural crest cell-specific deletion of Memo1 caused a failure of anterior cranial base ossification indicating a cell autonomous role for MEMO1 in the development of these structures, but palatal formation was normal, indicating a non-autonomous role in palatal closure.

our results show that Memo has a novel role in the S1P (show S1PR1 Antibodies) pathway and that Memo is needed to promote cell-autonomous S1PR activation.

tissue distribution of Memo in mice.

MEMO1 Antigen Profile

Protein Summary

May control cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton. Mediator of ERBB2 signaling. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization (By similarity).