Incidence: 5 to 7 persons per 100,000 population
Age of Peak Incidence: 55 years old
Survival: All therapies averaged - 3 months from time of Diagnosis by tissue Biopsy ( Brain Biopsy)
Reference: Wikipedia.Com\

Note; Incidence of primary Brain Malignancies : Approximately identical - Across All Decades of Life { all tumor types Averagedin this statistic]Note: Brain Tumors are ALWAYS biologically Malignant, Even if the microscopic findings are not those of a virulent Cancer; Viz; Meningioma : a Primary Brain tumors which are ALWAYS Biologically MALIGNANT; in spite of the Fact that Meningiomasnever metastasize beyond the confines of the skull..

I received a telephone communication from the father of a man with biopsy proven
Glioblastoma Multiformae.
This patient's brain biopsy was sent to a reference laboratory with their request
to use molecular biology research methods to evaluate the GBM BIOPSY and Resection tissue for
any and all evidence of Borrelia Species DNa, and for reactivities with
Validated Antibodies for detection of Borrelia burgdorferi protein epitopes.

The patient's Oncologists have continued the usual Chemo-therapies and Proton Beam Irradiation,
but have permitted the patient to receive ORAL Antibiotic combination therapy too, APPROPRIATE FOR
TREATMENT OF RESISTANT BORRELIA INFECTION, Per Infectious Disease Consult.
Preliminary results :
The tumor has been successfully debulked in the parietal lobe of the brain.( Two surgeries: Biopsy, and Excisions)
Radiation therapy ( Proton Beam) has been administered, per GBM Rx Protocols
ChemoTherapy ( ChemoRx)
Depatux ( experimental chemo; a Drug/Antibody Conjugate) ;
Avastin ( Angiogenesis inhibitor)
Keytruda ( Monoclonal immunologic Oncology )
No Cytotoxic Agents to date
Chemo-Rx was suspended because of Therapy related Thrombocytopenia.
which normalized as expected

Post Irradiation imaging of the Brain Surgical site
disclosed pronounced" inflammation patterns"
at the previous tumor site
This was interpreted by Radiology as "" unusual" ,
But.......
Not completely typical for the Brain imaging ---which would be expected from
Chemo-Rx and Radiation Rx effects Alone.

This story is not a conclusive statement of the effectiveness of:
1. Surgery alone ( debulking of Tumor)
2, Chemotherapy alone '( Immunologics but none of the Cytotoxics)
3. Radiation Therapy Alone
4. Possible amelioration of 1.,2., 3. above in this patient, but
Concurrent Antimicrobial Therapy ( oral route)

The Family is investigating the possible Neurosurgical research
placement of a catheter into the lateral ventricle ( on the side of the Tumor) (OMMAYA Reservoir)
which might allow for intraventricular administration of All Oncologist Ordered Antitumor agents
and possibly for Intraventricular adminstration of Combination Antibiotics
---------------------------------------

This morning, I received a telephone call from a SECOND GBM patient.

He has no conclusive Previous Diagnosis of any Lyme like condition.
He does describe excess of exposure to ticks in the past.
He is a Hunter.

He also describes that several of his Hunting Colleagues have died from
GLIOBLASTOMA MULIFORMAE.

i will explore this clinical information further when I interview this Second GBM patient later today..

Respectfully Submitted:

Alan B. MacDonald, MD,
Naples , Florida
April 29,2019

Last edited by inmacdonald on Sun 28 Apr 2019 23:37, edited 1 time in total.