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Production of nano-solid dispersions using a novel co-precipitation process – benchmarking the in vivo performance with spray dried dispersions

Authors:

Iris Duarte

Source:

10th PBP World Meeting

The use of amorphous solid dispersions (ASDs) to overcome the current solubility/bioavailability challenge of the new chemical compounds is gaining momentum. According to the recent DCS system, drugs belonging to BCS Class II (low solubility/high permeability) were sub-divided into two classes: Class IIa where molecules show dissolution-rate limited absorption, and the Class IIb where molecules present solubilitylimited absorption...