1. Pharmacokinetics“Oral delivery of oil-based CBD has been assessed in humans. Bioavailability from oral, oil-based delivery was estimated to be 6% due to significant first-pass metabolism. Probably due to its poor aqueous solubility, the absorption of CBD from the gastrointestinal tract is erratic, and the resulting pharmacokinetic profile is variable. Studies show CBD may preferentially accumulate in adipose [fatty] tissues due to its high lipophilicity [solubility in fat]” (World Health Organization, 2017).

“Human beings are mostly water, ranging from about 75 percent of body mass in infants to about 50–60 percent in adult men and women, to as low as 45 percent in old age. The percent of body water changes with development, because the proportions of the body given over to each organ and to muscles, fat, bone, and other tissues change from infancy to adulthood (Figure 1). Your brain and kidneys have the highest proportions of water, which composes 80–85 percent of their masses. In contrast, teeth have the lowest proportion of water, at 8–10 percent.”https://opentextbc.ca/…/26-1-body-fluids-and-fluid-compart…/https://water.usgs.gov/edu/propertyyou.html

2. Immune SupportImmune stimulation may occur at lower concentrations, but there is evidence of immune suppression at higher concentrations (World Health Organization, 2017).

3. PregnancyCBD has no effect on embryonic development (World Health Organization, 2017).