The team found that all other studies reported mortality higher than the general population.

Meta-analysis using a random effects model showed that the pooled estimate for standardized mortality ratios in Crohn's disease is 1.5.

The researchers undertook meta-regression to show that the standardized mortality ratio for these patients had decreased slightly over the past 30 years.

However, the team reported that this decrease was not statistically significant.

Dr Canavan's team concluded, “Assessing evidence from original studies and conducting a meta-analysis shows age-adjusted mortality risk from Crohn's disease is over 50% greater than the general population.”

“Mortality has improved since the condition was first recognized.”

“However, further evaluation of the patients studied in the cohorts included here is necessary to assess more recent changes in clinical practice.”