Fast forward to 2012. Under Coles' leadership, Onyx is now a three-drug company. The multiple myeloma drug Kyprolis received FDA approval in July. Stivarga, a new treatment for colon cancer, was approved in September. Coles had a lot to do with both of the new drugs. Kyprolis came to Onyx through the October 2009 acquisition of Proteolix (a deal that some investors disliked when it was announced.) At one time, Bayer tried to claim 100% ownership of Stivarga but an Onyx lawsuit and tough negotiating on Coles' part helped the keep its ownership stake. Onyx is no longer the weak spouse in its marriage to Bayer.