The protein encoded by MST1 contains four kringle domains and a serine protease domain, similar to that found in hepatic growth factor. Additionally we are shipping MST1 Kits (45) and MST1 Proteins (15) and many more products for this protein.

These data suggest that MSP (show MSMB Antibodies) is an effective inhibitor of inflammation and lipid accumulation in the stressed liver, thereby indicating that MSP (show MSMB Antibodies) has a key regulatory role in non-alcoholic steatohepatitis.

Study found that MST1 is strongly activated in a diabetic beta cell and induces not only its death but also directly impairs insulin (show INS Antibodies) secretion through promoting proteasomal degradation of key beta cell transcription factor, pancreatic and duodenal homeobox 1 (PDX1 (show PDX1 Antibodies)), which is critical for insulin (show INS Antibodies) production.

deacetylation of MST1 mediated by HBXIP-enhanced HDAC6 results in MST1 degradation in a chaperone-mediated autophagy (CMA) manner in promotion of breast cancer growth.

These data suggest that MSP is an effective inhibitor of inflammation and lipid accumulation in the stressed liver, thereby indicating that MSP has a key regulatory role in non-alcoholic steatohepatitis.

kinases, including Slk (show SLK Antibodies), Lok (show STK10 Antibodies) and Mst1, are inhibited by BI-D1870 but to a much lesser extent by BIX 02565 and that phosphorylation of some of their substrates is blocked by BI-D1870 in living cells.

Nicorandil alleviates post-MI cardiac dysfunction and remodeling. The mechanisms were associated with enhancing autophagy and inhibiting apoptosis through Mst1 inhibition.

Using a standard two-thirds partial hepatectomy (PH) model in young and aged mice, the activity of the core kinases MST1 and LATS1 (show LATS1 Antibodies) increased during the early hypertrophic phase and returned to steady state levels in the proliferative phase, coinciding with activation of YAP1 (show YAP1 Antibodies) target genes and hepatocyte proliferation.

MST1 Antigen Profile

Protein Summary

The protein encoded by this gene contains four kringle domains and a serine protease domain, similar to that found in hepatic growth factor. Despite the presence of the serine protease domain, the encoded protein may not have any proteolytic activity. The receptor for this protein is RON tyrosine kinase, which upon activation stimulates ciliary motility of ciliated epithelial lung cells. This protein is secreted and cleaved to form an alpha chain and a beta chain bridged by disulfide bonds.