=== Light-activated morphogenesis of breast cancer through activation of the "S1PR4" receptor: Unexpected findings from the synthesis of benzoxazole derivatives raise new questions on the risks of orthogonal riboswitch design ===

In regard of fine tuning E. coli for mutant protein acquisition, amplification, and overpression of the CAMK2B gene, the following excerpt from the OMIM.org database has this to say on the relevance of CAMK2 osmolitic dimer: "By Western blot analysis, Thiagarajan et al. (2002) found that the protein levels of Camk2a and Camk2b were inversely related during activity in cultured rat pup hippocampal neurons. The levels of Camk2a increased with heightened activity, and the levels of Camk2b increased with suppression of activity. Thiagarajan et al. (2002) hypothesized that the change in the ratio may help tune the Camk2 holoenzyme to changing intensities of Ca(2+) signaling."1

Exercise 1: Briefly Speaking, what is a cytosolic protein and which calmodulin-related receptors (hint: think high-affinity osmolitic regulation of the osmY gene, etc..) such mutant proteins may modulate?

Note: You're free to use your notebooks to accomplish this experiment, however wikipedia links will not be acceptable data.

Breast cancer/Alzheimer/Leukemia (DS, Parkinson, etc): Rhodopsin (Rho) gene-level interactions with S1PR4-directed protein overexpression lineage in HEK293 important note: The Rho signalling pathway is activated, for example, by bioactive sphingolipids such as sphingosine-1-phosphate (SPP) or by overexpression of Rho family members in tumorigenesis and metastases [16]. [Note: see Rhodopsin for info on photophosphorylation of the Rhodopsin kinase, a Ca2-dependent photoreceptor/GPCR transcription pathway?]

Notes:

To obtain the consensus pattern, see Accession number PS00237 here. (FASTA).