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We have investigated in the yeast Saccharomyces cerevisiae the mechanisms by which the Mediator, a 25 subunits complex, stimulates the transcription by RNA polymerase (Pol) II of activated genes. We identified a contact between Pol II and the Mediator in vivo and demonstrated that this contact is...

On April 28 the CNAG welcomed a group of ambassadors accredited to Madrid. The group toured the facility accompanied by the center staff and learned detailed information about the sequencing and data analysis process.Previously, the delegation attended a talk given by the General Manager of the...

Transcription initiation at promoters requires the assemblyofgeneral transcription factors (GTFs) and RNA polymerase(Pol) II. Recent works have shown that Pol II can also berecruited to, and transcribe distal regulatory regions.
We have analyzed initiation and elongation through genome-...

Genome-wide mapping of transcription factor-DNA interactions and chromatin epigenetic marks is essential to understand how the expression of the mammalian genome is controlled during normal life and disease.The human and mouse genomes contain about 30 genes encoding ATP-dependent chromatin...