Storing Blood for Analysis of DNA and Protein of Patients With Bladder Cancer in MAASTRO Clinic

Trial Information

Storing Blood for Analysis of DNA and Protein of Patients With Bladder Cancer in MAASTRO Clinic

It has already been known for a long time that cancer is a genetic disorder and that the
development of the illness is a very complex interaction between genetic and surrounding
factors. Also the response on therapy and the development and seriousness of side effects is
stipulated by this complicated collaboration of genetic and surrounding factors. Moreover it
is not only the DNA that plays an important role but also the systems of control at protein
level. At this moment a lot of questions remain to be answered because up till now the
studies were of rather restricted statistic strength with frequently inconsistent dates and
moreover retrospective. Major retrospective studies are necessary to distinguish the
relationship between DNA/protein patterns and clinical relevant endpoints like prognosis and
toxicity in which an as broad as possible patient group is being monitored. For this reason
we want to draw blood in MAASTRO clinic of all patients with bladder cancer and store it
encrypted so that we can perform DNA and protein analyses in future and to correlate the
results with survival and toxicity of the treatment.

Inclusion Criteria:

- Bladder cancer

Exclusion Criteria:

- Not able to comply with follow-up

Type of Study:

Observational

Study Design:

Observational Model: Cohort, Time Perspective: Prospective

Principal Investigator

Dirk De Ruysscher, PHD

Investigator Role:

Principal Investigator

Investigator Affiliation:

CCMO

Authority:

Netherlands: The Central Committee on Research Involving Human Subjects (CCMO)

Study ID:

P03.0607L

NCT ID:

NCT00157365

Start Date:

June 2003

Completion Date:

March 2010

Related Keywords:

Bladder Cancer

bladder cancer,

genomics,

proteomics

Urinary Bladder Neoplasms

Name

Location

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