Important Information

You should not use isavuconazonium if you have a genetic heart rhythm disorder called "Short QT syndrome."

Many drugs can interact with isavuconazonium, and some drugs should not be used together. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all medicines you use, and those you start or stop using during your treatment with isavuconazonium.

Before taking this medicine

You should not use isavuconazonium if you are allergic to it, or if you have:

a genetic heart rhythm disorder called "Short QT syndrome."

Some medicines can cause unwanted or dangerous effects when used with isavuconazonium. Your doctor may need to change your treatment plan if you use any of the following drugs:

Using isavuconazonium during pregnancy could harm the unborn baby. Tell your doctor if you are pregnant or if you become pregnant while using this medicine.

It is not known whether isavuconazonium passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine.

How should I take isavuconazonium?

Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not use isavuconazonium in larger or smaller amounts or for longer than recommended.

Isavuconazonium is available in a capsule form, and also in an injectable form.

Read all patient information, medication guides, and instruction sheets provided to you. Ask your doctor or pharmacist if you have any questions.

Isavuconazonium is first given in a "loading dose" every 8 hours for 48 hours. You will then use the medicine once daily as your "maintenance dose." Follow your doctor's dosing instructions very carefully.

You may take the capsule with or without food.

Do not crush, chew, open, or dissolve the capsule. Swallow it whole.

Store the capsules at room temperature, away from moisture and heat. Keep the capsules in their original blister pack, along with the packet or canister of moisture-absorbing preservative. Do not put isavuconazonium capsules into a daily pill box or pill organizer.

The injectable form of isavuconazonium is injected into a vein through an IV. You may be shown how to use an IV at home. Do not self-inject this medicine if you do not understand how to give the injection and properly dispose of used needles, IV tubing, and other items used to inject the medicine.

Isavuconazonium injection is a powder medicine that must be mixed with a liquid (diluent) before using it. You will then need to further dilute this mixture into a solution with another liquid in an IV bag. If you are using the injections at home, be sure you understand how to properly mix and store the medicine.

Each single-use vial (bottle) of the powder is for one use only. Throw away after one use, even if there is still some medicine left in it after injecting your dose.

Store the dry unmixed powder medicine in a refrigerator. After you mix the powder and diluent, keep the mixture in a refrigerator for up to 1 hour before further diluting it. If you store the final diluted solution in a refrigerator, use it within 24 hours after it was mixed. Do not freeze this medicine before or after mixing.

You may also store the final diluted solution at cool room temperature, but you must use it within 6 hours after mixing.

Use a disposable needle and syringe only once. Follow any state or local laws about throwing away used needles and syringes. Use a puncture-proof "sharps" disposal container (ask your pharmacist where to get one and how to throw it away). Keep this container out of the reach of children and pets.

You will need frequent blood tests to check your liver function.

Do not stop using isavuconazonium unless your doctor tells you to.

What happens if I miss a dose?

Call your doctor for instructions if you miss a dose of isavuconazonium.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

severe skin reaction--fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

Isavuconazonium dosing information

Comments:-Isavuconazonium sulfate is the prodrug of isavuconazole; 372 mg of isavuconazonium sulfate is equivalent to 200 mg of isavuconazole.-Maintenance doses should be started 12 to 24 hours after the last loading dose.

Comments:-Isavuconazonium sulfate is the prodrug of isavuconazole; 372 mg of isavuconazonium sulfate is equivalent to 200 mg of isavuconazole.-Maintenance doses should be started 12 to 24 hours after the last loading dose.

What other drugs will affect isavuconazonium?

Sometimes it is not safe to use certain medications at the same time. Some drugs can raise or lower your blood levels of isavuconazonium, which may cause side effects or make isavuconazonium less effective. Isavuconazonium can also affect blood levels of certain other drugs, making them less effective or increasing side effects.

Many drugs can interact with isavuconazonium. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any you start or stop using, especially:

This list is not complete and many other drugs can interact with isavuconazonium. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Give a list of all your medicines to any healthcare provider who treats you.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.