Sphere, by Michael Crichton. I read it three times. (The book is better than the movie, by the way. Way better.)

Leverage -- All Five Seasons Now on DVD

"The numbers are bad! The numbers are bad!" -- Hugo "Hurley" Reyes, Lost - Season 1
"Boone's death was a sacrifice that the island demanded." -- John Locke, Lost - Season 2
"When was it you lost your imagination, son?" -- Dr. Walter Bishop, Fringe - Season 1

It is kind of hard to pick just one. If I were recommending specifically in the Science Fiction genre I guess I would have to pick Larry Niven's Ringworld and Ringworld Engineers. Also, I would suggest John Varley's trilogy Titan, Wizard, and Demon. Now, if you are feeling brave, or just brave-ish, There are also varying degrees of Robert Heinlein you could tackle. Stranger in a Strange Land is one of his more accessible novels for an adult audience, and Starship Troopers is good as long as you don't expect it to even remotely resemble the Paul Verhouven movie. But, if you are a bit skittish about Heinlein, but still want to give it a try, he wrote some really good stuff that was aimed at a more youthful audience. Star Beast or Starman Jones are entertaining little romps for the Heinlein neophyte.

Atheism is not a religion. It is a personal relationship with reality.