custom script named editVirtDomain.sh and upload the same to /etc/appliance/customization

Note : you need to replace Zend Extension part with one copied from /usr/local/Zend/etc/php.ini in the attached scripts.

6.chmod both script to 755

Now all new domain created on server with any security level will be Zend enabled. If you want existing domain with high security to be zend enabled then you just need to re-save the site from Webppliance.