Trillions of microbes live in our digestive tract and influence our biology in profound and diverse ways. Several diseases, including obesity and inflammatory bowel diseases, have been associated with large-scale shifts in microbiota composition. The ability to address basic questions concerning community function and plasticity are fundamental to understanding the extent of causal relationships between host biology and microbiota perturbations, and whether the microbiota is a viable...

Delivering the performance equivalent of hundreds to over one thousand CPU cores per accelerated node, the TimeLogic solutions are ideal for data-intensive next-generation genomics. Life science institutions worldwide have chosen the TimeLogic brand as their optimal solution for high-throughput bioinformatics. The DeCypher and CodeQuest biocomputing solutions blend proven bioinformatics algorithms with ultra-fast accelerator hardware to achieve a perfect combination of performance, accuracy,...

Microbial-mammalian metabolic cooperation is defined as the human ‘metabonome’. Transgenomic co-metabolic interactions within the metabonome greatly increase system complexity and this presents a significant challenge for elucidating the mechanisms by which the intestinal micro biome influences the host phenotype. By measuring and mathematically modelling changes in the levels of products of metabolism found in mammalian biological fluids and tissues, metabonomics offers fresh insight...