1897: Giuseppe Sanarelli, MD

Giuseppe Sanarelli, MD, Italian bacteriologist injects the bacillus causing yellow fever five patients without their consent. Three of the five patients died. Dr. William Osler publicly admonished Sanarelli, stating: “To deliberately inject a poison of known high degree of virulency into a human being, unless you obtain the man’s sanction, is criminal.” (Subjected to Science)