When a person looses all or major respect for someone and/or starts to unlike that person.

girl 1. miley cyrus is such a hoe
girl 2. i know right, did you hear she may to pose for playboy? what a sloreguy1. yeah, shes hot though
girl 1. wow i just lost all respect for you
girl 2. me too i de-respect you now

i use to like heartless from kanye but after the VMAs i de-respected him.