Inactivated Vaccine Made from a US Field Isolate of PED Virus is Immunogenic in Pigs

The results of this US study demonstrate the immunogenicity of the porcine epidemic diarrhoea virus (PEDV) inactivated viral vaccines with a US strain.

PEDV is a highly pathogenic and transmissible virus in swine, first detected in the US in May 2013, and it has caused tremendous losses to the swine industry, according to Ron Batman of Newport Laboratories Inc.

In a paper in BMC Veterinary Research, he and co-authors there, at South Dakota State University, Kansas State University and Egypt's National Research Center, explains that, due to the difficulty in isolating and growing this virus in cell culture, few vaccine studies using cell culture propagated PEDV have been performed on US strains in pigs.

The objective of this study was to evaluate the humoral immune response to the selected inactivated PEDV vaccine candidate in a dose-titration manner.

PEDV was isolated from a pig with diarrhoea and complete genome sequencing found more than 99 per cent nucleotide identity to other US PEDV.