My sunroof is on the fritz. A few days ago, I tilted the rear up on my way home but couldn't get it to come back down to the closed position. I checked the manual and was able to close it with the tool. Today, I left my girlfriend in the car and she tried to open it, and again, it would not shut. This time though, the tool was left in my garage and we were nearly caught in the rain. I'm not due for service for another 4k miles; could I pull the sunroof fuse to prevent anyone from messing with it until I get it in for service or will other accessories be affected?

One of the reasons that members are asked to fill in a profile of their ride/location with UserCP ^^^ is that it often helps with answers. In your case, as you have not provided any details of the year of manufacture of your CLK 320, it is not possible to be certain with fuse details. However, for the sunroof fuse f9 there are just a few changes in the models. The fuse protects the OCP (overhead control panel) items, as follows:

Thanks for the response Keyhole, it's a '99. Today, I pulled the fuse and re-synced it and now it opens and closes in 1 motion. After it gets about 2/3 open though, it starts slowing down, like there's some hesitation or resistance. I found the DIY and lubed the guides and everything, even though there was still some there, but that didn't fix it. If I let it open all the way it slows down towards the end and then it's very tough to start moving again to close, but after that 1/3 mark it speeds up and closes like normal? There are no obstructions in it's path that I can see, any ideas?

What happens if you give the motor a little 'gentle assistance' by pressing on the roof while it is moving? If that overcomes the slowing down, there has to be some physical resistance to the roof movement somewhere. The motor is only stopped when the memory calculates that it is at the end of its travel, when it has been reset (normalized).

your sunroofs are begging to be cleaned and lubed and resynced at the dealer. for god sakes just have it done before you burn out your 400 dollar motor or destroy the teeth of the cables of your 1500 dollar sunroof frame. it prob wont cost you 75 bucks.