Role of endosomal antigen sorting of within human dendritic cells in T-cell priming

Friday 18 February 2011

ProjectRole of endosomal antigen sorting of within human dendritic cells in T-cell priming
We have shown that remodeling and repositioning of endosomal compartments within dendritic cells is important to T-cell activation. In this project we now try to address whether transport of antigen-specific peptide/MHC complexes is part of this process, in human dendritic cells, and which mechanisms contribute to productive T-cell contact (by tubular endosomes, or exosomes etc.).