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Abstract:

In Brief:

Between 2002 and 2009, 70% fewer hormone therapy prescription claims were received by a large pharmacy benefits management organization. Lower dosage and transdermal hormone therapy options have taken a larger share of prescribed hormone therapy.

Abstract:

In Brief:

This large population-based study describes changes in menopause hormone therapy prescribing in the United States, including dose, formulation, patient age, and prescriber specialty, over a 10-year period.

Abstract:

In Brief:

The effects of two different concentrations of a transdermal estradiol gel on hot flushes and vaginal cytology were evaluated in separate clinical trials. Reductions in hot flush frequency and severity, shifts to higher vaginal maturation value, and the percentage of participants having a response were significant with 0.06% estradiol applied daily to the arm.

Abstract:

In Brief:

This study showed that systemic or topical estrogen reduces numbers of vaginal sensory and autonomic axons in postmenopausal women, raising the possibility that changes in innervation may contribute to some menopausal symptoms.

Abstract:

In Brief:

Cognitive impairment is significantly associated with lower bone mineral density in postmenopausal women. This finding suggests that estrogen deficiency may be one of the contributing factors to cognitive aging.

Abstract:

In Brief:

Best fit model was obtained to demonstrate predictors of mandibular bone mineral density (mBMD) in premenopausal and postmenopausal Indian women. Screening for biomarkers should be useful to assess mBMD status.

Abstract:

In Brief:

Changes in circulating steroid hormone emanating from the adrenal during the menopausal transition may be more important than the decline in ovarian function in terms of altering the estrogen-androgen balance.