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Course Availability

This course is only available to trainees days after purchase.
It would need to be repurchased by the trainee if not completed in the allotted time period.
This course is no longer available.
You will need to repurchase if you wish to take the course again.

Description

An in-depth review of the underlying physiology and pathophysiology of selected organ systems and disease states relevant to the care and management of critically ill patients. It is ideal for the resident in training, mentors of residents in training and individuals with a strong interest in the science behind emergency and critical care medicine.

Objectives

Understand the physical effects that red blood cells have on supporting coagulation

Red blood cells can influence coagulation by altering blood viscosity and flow through the microcirculation. The formation of rouleaux may also contribute to coagulation.

Understand the chemical and receptor medicated effects that red blood cells use to influence coagulation

The release of substances such as ADP from red blood cells and the exposure of phosphatidyl serine on red blood cell membranes can activate platelets and coagulation and support thrombin generation, in addition to providing fibrinogen binding areas.

Free heme can trigger oxidant injury which can promote or incite inflammation. In addition, heme can upregulate tissue factor expression and result in a procoagulant phenotype. Free heme is also associated with the phenomenon of netosis, which can also promote coagulation.

Dr. Brainard is a professor of critical care at the University of Georgia, and is board certified in both veterinary anesthesiology and emergency and critical care. Dr. Brainard directs the ICU and emergency service at UGA with his colleague, Dr. Amie Koenig, and also serves as an associate editor for the Journal of Veterinary Emergency and Critical Care. Dr. Brainard's research interests include coagulation, drugs that affect platelet function, and techniques for the diagnosis of hypercoagulability in veterinary patients.

Current Accreditations

This course has been certified by or provided by the following Certified Organization/s: