Theoretical and experimental studies of the regulation of the transport of water and solutes across the walls of microvessels; experimental studies involving the cannulation and perfusion of individual microvessels.

Causes, treatment and surgical repair, and rehabilitation of soft tissue injuries and disease to the knee; muscle function, neuromuscular control, modeling, and simulation of human movement; sports biomechanics and equipment design with emphasis on cycling both on and off road.

Computational and theoretical approaches to the study of biological networks at the cellular and molecular level. Multiscale and multilevel approaches to study biomolecular processes. Assembly of macromolecular complexes on DNA, membranes, and scaffolds. Statistical mechanics basis of gene regulation and signal transduction. Noise in cellular processes. In vivo biomolecular mechanics. Molecular biophysics: membranes, membrane associated proteins, and their interactions with small molecules and drugs.