GREMLIN Results:
Residue pairs sorted by strength in covariance:Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

i

j

Raw Score

Scaled Score

75_L

78_E

0.95207

3.193

91_K

118_E

0.91721

3.076

90_A

118_E

0.90299

3.028

78_E

82_K

0.81492

2.733

70_V

107_A

0.78576

2.635

69_N

72_A

0.75624

2.536

85_L

90_A

0.73733

2.473

81_A

115_G

0.73516

2.465

79_L

83_R

0.69645

2.336

82_K

86_E

0.68438

2.295

26_L

37_A

0.67989

2.280

55_S

83_R

0.58983

1.978

10_K

97_G

0.55023

1.845

112_A

117_L

0.53672

1.800

39_I

84_A

0.53273

1.787

31_S

36_Y

0.51619

1.731

39_I

80_L

0.51238

1.718

74_Y

114_E

0.48565

1.629

37_A

80_L

0.48415

1.624

74_Y

111_G

0.46889

1.572

37_A

108_L

0.45985

1.542

111_G

115_G

0.45919

1.540

35_I

108_L

0.4488

1.505

41_D

44_K

0.42105

1.412

7_R

11_L

0.40535

1.359

74_Y

78_E

0.40089

1.344

24_P

42_D

0.40087

1.344

27_V

40_I

0.40048

1.343

82_K

85_L

0.40001

1.341

5_R

9_R

0.38952

1.306

92_V

119_F

0.37946

1.273

39_I

89_I

0.3721

1.248

3_K

7_R

0.3689

1.237

30_R

104_R

0.36727

1.232

53_T

72_A

0.3648

1.223

46_G

87_K

0.36037

1.209

6_R

99_Y

0.35518

1.191

34_H

54_L

0.35277

1.183

11_L

15_R

0.352

1.180

39_I

92_V

0.34723

1.164

81_A

111_G

0.34524

1.158

51_A

79_L

0.34304

1.150

26_L

112_A

0.33648

1.128

19_G

24_P

0.33162

1.112

15_R

18_K

0.33083

1.109

51_A

83_R

0.32099

1.076

108_L

111_G

0.31588

1.059

79_L

88_G

0.31083

1.042

79_L

82_K

0.30297

1.016

71_E

74_Y

0.30162

1.011

40_I

49_A

0.29899

1.003

78_E

114_E

0.29372

0.985

55_S

79_L

0.29369

0.985

32_N

68_K

0.2926

0.981

21_A

44_K

0.29142

0.977

75_L

79_L

0.28835

0.967

68_K

72_A

0.28585

0.959

21_A

43_S

0.28314

0.950

26_L

80_L

0.2801

0.939

80_L

112_A

0.2797

0.938

2_K

10_K

0.27841

0.934

27_V

97_G

0.27698

0.929

34_H

53_T

0.27602

0.926

57_E

60_K

0.27503

0.922

71_E

75_L

0.275

0.922

109_A

113_R

0.27369

0.918

58_L

79_L

0.269

0.902

61_Y

75_L

0.26879

0.901

77_G

108_L

0.26845

0.900

70_V

74_Y

0.26843

0.900

106_K

110_D

0.26345

0.883

18_K

43_S

0.26311

0.882

19_G

22_E

0.26124

0.876

28_V

108_L

0.25758

0.864

4_R

11_L

0.25388

0.851

3_K

6_R

0.25347

0.850

7_R

10_K

0.25193

0.845

16_K

19_G

0.25177

0.844

57_E

83_R

0.25155

0.844

29_F

99_Y

0.24832

0.833

51_A

55_S

0.24797

0.832

112_A

119_F

0.24735

0.829

58_L

75_L

0.24562

0.824

15_R

19_G

0.24435

0.819

35_I

105_V

0.2403

0.806

27_V

99_Y

0.23896

0.801

69_N

104_R

0.23883

0.801

76_V

108_L

0.23877

0.801

29_F

36_Y

0.23761

0.797

80_L

108_L

0.23532

0.789

10_K

20_T

0.23467

0.787

9_R

34_H

0.23208

0.778

78_E

111_G

0.23087

0.774

18_K

22_E

0.22948

0.770

4_R

33_K

0.22925

0.769

36_Y

102_H

0.22613

0.758

5_R

32_N

0.22368

0.750

83_R

87_K

0.22262

0.747

80_L

117_L

0.22231

0.746

4_R

7_R

0.22178

0.744

11_L

16_K

0.22066

0.740

48_L

89_I

0.22056

0.740

30_R

97_G

0.21983

0.737

85_L

115_G

0.21946

0.736

76_V

80_L

0.21868

0.733

108_L

119_F

0.21704

0.728

77_G

111_G

0.21616

0.725

3_K

99_Y

0.21525

0.722

49_A

83_R

0.21469

0.720

23_R

91_K

0.21411

0.718

35_I

73_A

0.21117

0.708

61_Y

67_T

0.21093

0.707

56_K

60_K

0.2099

0.704

3_K

11_L

0.20988

0.704

103_G

109_A

0.20939

0.702

22_E

91_K

0.20828

0.698

35_I

76_V

0.20808

0.698

26_L

92_V

0.20433

0.685

72_A

104_R

0.20391

0.684

34_H

56_K

0.20159

0.676

25_R

95_D

0.20154

0.676

10_K

13_I

0.198

0.664

77_G

112_A

0.19792

0.664

6_R

9_R

0.19749

0.662

11_L

18_K

0.19593

0.657

84_A

89_I

0.1958

0.657

9_R

12_R

0.1952

0.655

34_H

68_K

0.19473

0.653

3_K

10_K

0.19467

0.653

94_F

109_A

0.19258

0.646

58_L

72_A

0.19249

0.646

94_F

103_G

0.19249

0.646

29_F

32_N

0.19223

0.645

2_K

32_N

0.19046

0.639

16_K

20_T

0.18998

0.637

36_Y

99_Y

0.18893

0.634

45_G

48_L

0.18728

0.628

55_S

76_V

0.18692

0.627

13_I

20_T

0.1862

0.624

7_R

15_R

0.18546

0.622

11_L

27_V

0.18533

0.622

2_K

7_R

0.18513

0.621

40_I

45_G

0.18464

0.619

11_L

72_A

0.18434

0.618

19_G

42_D

0.18357

0.616

7_R

70_V

0.18274

0.613

77_G

81_A

0.1827

0.613

2_K

5_R

0.18203

0.610

54_L

72_A

0.18136

0.608

2_K

8_R

0.18085

0.606

10_K

27_V

0.17967

0.603

36_Y

106_K

0.17957

0.602

81_A

112_A

0.17938

0.602

68_K

71_E

0.17919

0.601

80_L

84_A

0.17856

0.599

53_T

76_V

0.17831

0.598

2_K

9_R

0.17806

0.597

84_A

117_L

0.17806

0.597

55_S

58_L

0.17642

0.592

83_R

86_E

0.17567

0.589

18_K

91_K

0.17549

0.589

2_K

6_R

0.17365

0.582

42_D

47_T

0.17344

0.582

103_G

113_R

0.17323

0.581

95_D

103_G

0.17261

0.579

24_P

41_D

0.17164

0.576

96_R

103_G

0.17106

0.574

5_R

15_R

0.17031

0.571

58_L

93_V

0.17011

0.570

9_R

13_I

0.16902

0.567

Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.

HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits: Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)