In women in natural menopause without hysterectomy, what are the relative efficacies of pharmacologic and nonpharmacologic treatments for vasomotor symptoms (VMSs)?

Included English-language studies compared hormonal and nonhormonal pharmaceuticals and nonpharmaceuticals with placebo for 4 to 26 weeks in women ≥ 45 years of age in natural menopause (amenorrhea ≥ 12 consecutive mo) who had an intact uterus. Outcomes included frequency of VMSs and adverse events (treatment discontinuation and vaginal bleeding).