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Contents

One of the world’s largest biomedical research centres is nearing completion in a heavily built-up district of central London. 1953, Francis Crick – together with his colleagues James Watson and Maurice Wilkins – identified the structure of DNA . This proved to be of significant importance to biomedical research, and earned Crick, Watson and Wilkins the 1962 Nobel Prize in Physiology or Medicine.

In 2015, the institute that bears his name will open its doors to the scientific community. Located opposite London’s St Pancras Station it will be an entirely new organisation, with a distinctive vision of how medical research should be conducted. This involves bringing the best minds together and engaging in extensive collaboration between scientists, biologists, chemists and physicists, with the aim of discovering treatments and cures for human diseases and ailments.

The building is made up of two bars – north and south – which are connected by an eastwest atrium. The bars are further divided by a north-south atrium extending across the building.

The location was carefully evaluated, placing the institute within a cluster of hospitals, educational institutions and learned societies, which are already working on some of today’s most important medical research.

The project was conceived as a multidisciplinary, life-science researchfacility, incorporating primary and secondary shared/dedicated laboratory areas, plus associated write-up areas, biological research facilities (BRF) – with high-containment laboratories alongside chemistry and dry-lab functions – together with all the required amenity, administration, auditorium, restaurant and support functions. Each of these elements presents its own particular engineering and design requirements.

The site is landlocked, with the British Library to the south, St Pancras Station to the east, and listed housing blocks to the north and west. Below ground, the surrounding streets are crowded with utilities, including two 120-year-old, low-pressure gasmains.

The area is densely populated and there are two tube lines running underground, close to the site. The subterranean St Pancras Box –which incorporates the St Pancras International domestic rail station – is adjacent to the site, on the east side. Modern laboratory buildings can only accept extremely low levels of vibration transmitted within the building structure, so the projectadopted a blanket level of Vibration Criteria-A (VC-A) across all laboratory floors, with local isolation tables in areas – such as the imaging zone – that required more stringent VC-D/E. All MEP plant and equipment that generates vibration must be fully isolated from the structure by means of anti-vibration mountings, spring hangers and supports.

The sophisticated researchequipment is very sensitive to electromagnetic emissions, which required the MEP equipment to be separated from any receivers by sufficient distances to eliminate interference. The most sensitive equipment has a further level of protection, with both passive and active shielding provided.

The BRF, while not high-containment, is also subject to considerable scrutiny by the Home Office and the Department for Environment, Food and Rural Affairs (Defra).

Very high levels of ventilation are required with 20 air changes per hour. The project also has sophisticated diurnal lighting control, acoustic control and high-efficiency particulate arrestance (HEPA) filtration of the air supplies and exhaust. The BRF also incorporates stringent odour control, which is dealt with primarily by careful architectural design, coupled with ventilation regimes.

The Francis Crick Institute is the first laboratory – and one of the first buildings of any type – to be subject to the latest (2010) energyregulations, which demand an average of approximately 25% reduction in carbon levels. This was achieved, along with an ‘Excellent’ BREEAM rating.

MEP plant and systems have to be functional and adaptable, and fit within the overall architectural form of a building. The brief for the Francis Crick Institute was for it to be aesthetically pleasing, while providing good spatial planning and an efficient working environment. This presented considerable challenges to the architects, because space was constrained and there were stringent planning requirements. The impact of the building’s height and massing had to be carefully considered, particularly in relation to nearby housing, which had rights to light.To a large extent, this drives the MEP servicing strategies. The BRF is all in the 16m deep basement, along with most of the high-containment laboratories. This has meant large interstitial floors are required to accommodate the sizable HVAC and other services required to support these areas.

To restrict and control the potential vibration of the structural-loading impacts of heavy plant, most of this is also located in the basement in its own energy centre.Air handling equipment requires large fresh air intake, as well as large discharge stacks. (The total fresh air requirement is 430m3/sec – equivalent of emptying an Olympic pool in less than 10 seconds.)

The general laboratory areas consist of primary, shared secondary, dedicated secondary and write-up areas, based on a 6.2m x 9m structural grid, with adaptability built into the MEP design, to allow future changes driven by the science.

Primary laboratories are main laboratories, which can accommodate a range of different sciences. Shared secondary laboratories contain high value assets, which are used extensively.

Dedicated secondary laboratories are areas containing specific laboratory equipment that is dedicated to a particular area.

The laboratory spaces on the north and south bars are designed to be open, with sight lines between laboratories. They are connected with link bridges and collaborationspaces to facilitate interaction between scientific groups.

The general laboratory areas are designed – from the servicespoint of view – to operate as a Containment Level 2 (CL2) area, with the write-up areas located outside the laboratory.

This is in addition to the hundreds of thousands of other MEP products, and devices that have needed to be procured, delivered and installed on a ‘just in time’ basis. A separate article on modularisation and offsite assembly is planned for a future issue.

Francis Crick was noted for his intelligence, openness to new ideas, and collaborations with different disciplines, and all of these qualities were needed by the engineeringdesign team to deliver this groundbreaking project.

Electromagnetic compatibility/interference – the profile of the site was assessed in order to establish background levels Environmental studies – a number of studies were performed, including the impact the building would have on existing air quality

Dispersion modelling – numerical analysis to confirm that the 32 large extract air stacks and thermal flues are compliant with emissions requirements. In addition, wind-tunnel testing done to confirm emissions would not re-enter the fresh air intakes

Odour modelling – conducted using both numerical and empirical testing of BRF waste and feed materials on exhaust streams.