Omeprazole may block the breakdown of clonazepam by the liver. If this happens, blood levels of clonazepam could be increased. This could increase the risk of side effects including prolonged sedation and impaired coordination. If these drugs are used together, your doctor may want to monitor you closely for side effects. If you are experiencing problems, it may be necessary to adjust the dose of clonazepam or to reduce the number of doses that are taken throughout the day. Your doctor may also consider using lorazepam as an alternative to clonazepam because it is less likely to be effected by this potential interaction. You may want to ask your healthcare provider about this potential interaction if you think you are having problems.

This interaction is poorly documented and is considered minor in severity.

(Note: Not all drug interactions are known or reported in the literature, and new drug interactions are continually being reported. This information is provided only for your education and for you to discuss with your personal healthcare provider.)