We supposed the diagnostic significance of the ratio between proinflammatory and anti-inflammatory cytokines in the peritoneal cavity and system blood flow in patients with abdominal sepsis. So we tried to correct such disbalance with glutamine intravenous and enteral supplementation.

The probability of survival on day 28 was 73% in the standard therapy group, in the group with glutamine intravenous - 78%, in the group with glutamine intravenous and enteral - 84%. We did not fix the decrease of the duration of respiratory support in all of the groups. The duration of acute intestinal injury was significantly different (standard group 49 hours vs 38 hours in group with glutamine intravenous supplementation - 35 hours in group with intravenous and enteral glutamine supplementation). We investigated the prevalence of the concentration of proinflammatory cytokines in the peritoneal cavity and in blood serum according to the molar coefficient in the control group. The molar coefficient had a positive correlation with the SOFA scale. In group 2 (glutamine intravenous) the molar coefficients were decreased to the prevalence of anti-inflammatory cytokines (in serum on day 3, in peritoneal on day 2). In group 3 (glutamine intravenous and enteral) we investigated the significance difference and decrease of all cytokine levels in blood serum and in the peritoneal cavity.