L-Mesitran Archive 2007-2009

L-Mesitran for diabetic feet

A recent study shows that even the most challenging diabetic wounds can be treated successfully with the L-Mesitran honey based products. In one of the most prestigious hospitals and reference centers of Asia, the Kuala Lumpur Hospital, a study was done to see whether L-Mesitran could prevent amputation and reduce antibiotic use. In this study the L-Mesitran products have demonstrated convincingly: - that wound infections were rapidly cleared; - that additional antibiotics were not necessary; - to prevent eminent (partial) DM foot amputation; - to quickly debride wounds; - to reduce wound size rapidly.

Please do not hesitate to contact us, should you have questions about the presented study or if you're interested in participating in a similar study.

November 30, 2009

Case Study November 2009 - part 2

Did you know that L-Mesitran is also becoming a favorable treatment for wounds amongst veterinarians? The following case study shows the successful veterinarian use of L-Mesitran Soft. A 6 year old mare was attacked by a stallion; big wounds in the neck and on the leg were the result; even the muscle layer and the mane were separated from each other. The veterinarian was not able to suture the wounds. The initial treatment with TMPS and colloidal silver water dried out the wounds and therefore the treatment with L-Mesitran Soft was started 19 days post trauma. The severe wounds healed completely in 7½ and 9 weeks without adverse effects.

Perhaps this case study has made you aware of the fact that L-Mesitran ointment and Soft can also be used for the treatment of animals; you even might already have had similar experiences which you would like to share; please do not hesitate to do so!

November 25, 2009

Case Study November 2009 - part 1

In this edition we would like to share a successful case from Switzerland. The case study is about a 93 year old female nursing home resident with a traumatic wound on her right lower leg. The hydrocolloid treatment was initially successful, but the patient’s condition (incl. the wound) deteriorated to an almost terminal situation. Despite these challenging conditions the L-Mesitran products were able to debride and fully heal the traumatic leg wound in a timeframe of 13 weeks.

Click here to read the complete story. The case is also available in German and in Dutch.

Please do not hesitate to contact us, should you appreciate receiving a copy by email.

November 10, 2009

Case Study October 2009

The holiday season is over and we hope that you have enjoyed it. As of today we will continue our email service. This time we would like to share an interesting case study with L-Mesitran ointment and Border, particularly interesting in the light of reducing antibiotic treatments.

Case 009 - A 42 year old woman (smoker) presented a Staphylococcus aureus infected wound after surgery to her left leg. Despite the two-week treatment with antibiotics, the wound worsened. The switch to L-Mesitran was made and the Ointment/Border managed to combat the infection in only 4 days; the wound was completely healed in roughly three weeks.

We are proud to announce today’s publication by prof. Donald Du Toit and Ben Page on the cell toxicity of honey and silver dressings in the influential Journal of Woundcare.

Their thorough in vitro research at the Stellenbosch University was to determine whether L-Mesitran Hydro and silver products either stimulate cell growth or kill growth (cytoxicity).

They conclude that:

L-Mesitran

- Significantly stimulates the growth of new cells (keratinocytes and fibroblasts); - Results in a good new cell structure without abundant scar formation

- Is not cytotoxic;

- Has great advantages over silver products, especially when wound healing is the objective.

Silver

- Has a high kill rate of cells and is cytotoxic;

- The remaining cells are generally non vital;

- Silver has a negative effect on the migration and the shape of cells;

- After three weeks all keratinocytes and fibroblasts were eliminated! The researchers emphasize that on the basis of these robust scientific results, they support the continued use of honey-impregnated dressings by wound care practitioners. They do not recommend the use of silver dressings for wound healing.

The article will be available from the website of the Journal of Woundcare or alternatively you will be able to find an abstract via Pubmed shortly. About the Journal of Wound Care (JWC); the JWC is the definitive wound-care journal and the leading source of tissue viability research and clinical information

PRESS-RELEASE September 10, 2009

Case Studies June 2009 - part 2

We would like to share two case studies about the application of L-Mesitran ointment for the treatment of diabetic foot wounds.

Case C-031 Diabetic foot

A 47-year-old diabetic patient had a wound by an unknown cause to her right foot. The wound was initially treated with fucidate sodium and antibiotics with little to no effect. Treatment with L-Mesitran made healing possible within 9 weeks. Click here to read the complete story.

A randomized and reviewer blinded study with an L-Mesitran group (n=16) compared to a conventional therapy group (n=16) showed that blood glucose levels were not affected by L-Mesitran. Furthermore the study showed that the treatment with L-Mesitran achieved healing without adverse effects and that it is more cost effective than conventional therapies. An example can be found in case c054.

Triticum wishes you a joyous holiday season. This email service will be continued in September 2009. Meantime please do not hesitate to contribute to this series and share your stories with us!

June 23, 2009

Case Studies June 2009

We would like to share two interesting case studies about patients with pressure sores treated with L-Mesitran ointment.

Case C-028 Pressure Sore, venous insufficiency

A 72 year old patient with venous insufficiency had a pressure sore on his left foot. The wound was necrotic and the underlying pathology made healing challenging. The ointment provided essential nutrients to the wound bed, which led to a successfully healed wound in 104 days. Click here to read the complete story.

Case C-040 Pressure Sore

A 79 year old dementia patient had a pressure ulcer on her right heel due to repetitive motion of her right leg. The patient was very restless and kept removing the dressings. Despite these circumstances, L-Mesitran Ointment managed to heal the wound in five months while other methods and materials used prior to this treatment were unsuccessful. Click here to read the complete story. We would like to hear your experiences too.

We are proud to hereby reveal our brand new L-Mesitran product brochure. The new brochure is updated with the latest literature on wound healing with our honey-based products.

You can click here to open the new brochure in pdf. Should you experience any troubles during the download, or should you be interested in a press-quality pdf-version of the brochure, please do not hesitate to contact us.

Your feedback is highly appreciated.

May 18, 2009

Case Studies May 2009

We would like to share two interesting case studies with L-Mesitran ointment.

Case C-026,

Diabetic foot A 49 year old male patient had complications on his right foot after amputation of a toe. The patient is a diabetic, suffers from severe venous insufficiency and is a heavy drinker with bad personal hygiene. The wound was initially treated with Povidone iodine and alginates. This treatment stagnated the debridement and wound healing. The switch to L-Mesitran ointment was made and the wound healed within 5 months. Click here to read the complete story.

Case C-038, Pressure sore

An 80 year old woman (diabetes, stroke, high blood pressure) with a reasonable health had a pressure ulcer on her left heel. The honey-based ointment L-Mesitran provided the right conditions for wound healing. The wound healed completely in 18 weeks total. No antibiotics were used and the ointment did not have any influence on the blood glucose levels. Click here to read the complete story.

Would you like to contribute to the case study series with similar L-Mesitran experiences? Please do not hesitate to share your story with us.

May 4, 2009

Case Studies April 2009, part 2

We would like to share two interesting case studies with L-Mesitran Ointment.

Case C-024 Trauma, Venous insufficiency

A 78 year old lady bumped into an object and she developed a wound on her lower right leg. The wound did not heal because of venous insufficiency. A combination of compression therapy and the honey based L-Mesitran Ointment was used, resulting in wound healing in 64 days. Click here to read the complete story.

Case C-037 Pressure sore

An 89-year-old woman with a very poor overall health status had a decubitus wound on her right heel. The wound was first treated with several other products with little to no effect and then the switch to L-Mesitran was made. Within 9 weeks the pressure sore on the heel of this 89-year old patient debrided and granulation was achieved. The wound healed without complications or adverse effects. Click here to read the complete story.

April 16, 2009

Case Studies April 2009

We would like to share two interesting case studies with L-Mesitran Soft and Ointment.

Case C-030 1st and 2nd degree burns

A 38 year old male patient sustained burn injuries on both his arms due to a car accident. L-Mesitran Soft quickly desloughed and debrided the wounds. The patient showed quick epithelialization on the right arm, left arm and hand. In this case the wounds healed in only seventeen days with little to no scarring. Click here to read the complete story.

Case C-025 Decubitus, Rheumatoid arthritis

An 86 year old female with rheumatoid arthritis (RA), has decubitus wounds caused by the disformation of the extremities. Especially on these locations ulcerations can easily be formed and are diﬃcult to heal because of the impaired blood circulation, because of the tightened skin around the joints. The home care nurse started the L-Mesitran ointment treatment quickly after the wounds were present. In this case study the wounds treated with L-Mesitran healed fast, despite the impaired blood circulation. Click here to read the complete story.

April 1, 2009

Case Studies March 2009, part 2

We would like to share two interesting case studies with L-Mesitran ointment.

Case C-020, Trauma

A 15 year old girl hurt her lower right leg when she got of a bus. The wound was initially treated with povidone iodine over a three week period,which delayed wound healing.The switch to L-Mesitran Ointment was made for its quick debriding capacity and its capability to create a moist wound healing environment.The wound healed in 18 days. Click here to read the complete story.

Case C-73 Infected abscess, Type 2 Diabetic

An 80 year old woman had a large abscess on her right hip, which was surgically removed. The wound was infected with Ps. Aeroginosa and Candida Glabrata. Culture swabs proved in vivo that L-Mesitran Ointment was responsible for eliminating the Ps. Aeroginosa & fungal load in the wound and granulation tissue was quickly formed. Remarkable was that the use of L-Mesitran Ointment was stopped several times when culture swabs showed no growth of organisms. The Povidone iodine treatment was used again, but then the swabs (taken every three days) showed growth of Ps. Aeroginosa again. Thus proving the anti-Pseudomonas activity in this patient of L-Mesitran Ointment. Click here to read the complete story.

Do you have similar experiences with our products and would you like to contribute to the case studies series? Please do not hesitate to share your story with us.

March 16, 2009

Case Studies March 2009

Over the past few weeks we have shared several case studies done with L-Mesitran with you. We hope this service is an added value to you. We appreciate your feedback on this service and how we can improve it. We look forward to your thoughts. Meanwhile, please find below another interesting case study with L-Mesitran Soft.

Case C-019, Trauma

A 69 year old man had a wound on his lower right leg after an accident with a fork-lift truck. The wound was initially treated with Povidone Iodine, with no progress. This case shows that Povidone Iodine often is used for the wrong reason. Povidone Iodine is an antiseptic that can be used just for that purpose; it is active for 4 hours maximum; it is not a primary aid in stimulating epithelisation, like L-Mesitran. Click here to read the complete story.

March 2, 2009

Treatment of a bilateral necrotic leg ulcer with Mesitran

The Department of Tissue Viability, Aberdeen (UK), published a case report on the successful treatment of a necrotic leg ulcer with L-Mesitran dressings. An 82 year old female had a large necrotic and sloughy wound (10x12cm). After 10 days the wound had reduced in size and by 27 days the wound was almost healed. The case demonstrates, according to John Timmons (TVN), an excellent healing response with the Mesitran dressing promoting the removal of slough, while encouraging the formation of granulation tissue and providing protection of this delicate growth. By maintaining a moist wound environment epithelial tissue growth was encouraged.The full article is available on demand. (Wounds UK 2008, vol. 4, no 4, 129).

February 18, 2009

Case Studies February 2009, part 2

We would like to share another two interesting case studies with L-Mesitran Soft.

Case C-018, Postoperative wound

A 7 year old boy underwent an appendectomy. After the surgery the wound site became infected and as a result the suture opened and exudates leaked from the wound. Postoperative wound infection after appendectomy is caused by preoperative contamination of the abdominal wound. The most common method of controlling the infection is with antibiotics. In this case however, antibiotics had little to no effect and the switch to L-Mesitran Soft was made. Click here to read the complete story.

Case C-29, Fungus, foot

A 52 year old man suffers from scaly feet. The patient tore off scales until bleeding, with as a result the wound on the heel. Also fungus was observed between the toes. To prevent bacterial infection L-Mesitran was chosen for treatment. It was also expected that the fungus between the toes could effectively be treated. This case is a perfect example of how this condition can be treated in a podiatry setting. Click here to read the complete story.

February 17, 2009

Case Studies January 2009, part 2

We would like to share another two interesting case studies with L-Mesitran Ointment.

Case C-013, Pseudomonas infected leg wound

A 45 year old female presented a Pseudomonas spp. infected wound on her left ankle. The wound was initially treated with Acetic acid compresses with little to no effect on reducing the infection. Thereafter the wound was treated with L-Mesitran ointment and it healed completely without the use of antibiotics. The patient herself treated the wound, without any help from home care. Click here to read the complete story.

Case C-014, Trauma

A 23 year old male patient had a traumatic wound on his right lower leg. After being treated with Povidone iodine, the wound became necrotic. Treatment with L-Mesitran was started. Already after 1 day (!) the ointment was responsible for the weakening of the necrosis, which could then be manually removed. This case study is a perfect example of L-Mesitran’s debriding capability. Click here to read the complete story.

Please do not hesitate to share your story with us, should you have similar experiences with L-Mesitran treatments.

January 19, 2009

Case studies January 2009

Triticum wishes you a very Happy New Year! To start 2009 we would like to update you with two new interesting case studies with L-Mesitran Soft.

Case C-015 Trauma/Varices

A 61 year old female had a wound on her lower leg after treatment for varices. This case shows that the initially started topical antibiotic treatment wasn't as successful as the treatment with the honey-gel. The use of L-Mesitran helps in bringing down the use of antibiotics and the resistance against them. Furthermore antibiotics are only useful in killing bacteriae, not for the promotion of wound healing. Click here to read the complete story.

Case C-016 Skin Tear

A 90 year old female with a skin tear was successfully treated in four weeks with L-Mesitran Soft. Dressing changes may injure the fragile wound via skin stripping; that's why the challenge was not to damage the peri wound area, establish quick debridement, prevent infection and promote a quick wound healing. Click here to read the complete story.

January 6, 2009

Recent publications L-Mesitran

The Wounds UK published an article on L-Mesitran products. Clare Morris, a Tissue Viability Advisor North Wales NHS Trust, wrote: "The Mesitran range is an example of a modern wound care product that uses the healing properties of honey. It offers a useful range of medical grade honey dressings to manage a variety of chronic wounds in a wide range of stages of the healing process and is especially useful in debridement." Wounds UK, 2008, Vol 4, No 3, p.84-87 (article available on demand).

November 3, 2008

News Release June 2008

L-Mesitran® promotes fibroblasts. L-Mesitran® dressings promote fibroblast and keratinocyte monolayers ex vivo, which is relevant in the clinic and to wound healing and care. This is the conclusion of the research by Professor Du Toit et al. from the University of Stellenbosch, South Africa.

The article was published in the May 2008 edition of The Specialist Forum Journal in South Africa from Char Publications. According to the authors, honey-based L-Mesitran® sterile impregnated dressings have been used with increased success in the treatment of acute and chronic ulceration, trauma and burns. Advantages of L-Mesitran® include: antibacterial debridement effect, reduction of malodour, anti-inflammatory and safety profile.

The Du Toit studies show that L-Mesitran® dressings have unique cell biology properties previously not widely documented. In-vitro and tissue culture work show that L-Mesitran®:

These scientific tissue culture observations and quantification data lend support to the continued application of topically applied honey-based dressings in adult wound healing and care (indolent wounds, bedsores, venous ulcers, diabetic foot ulceration, and chronic burn wounds). Clearly, this new generation of dressing is superior to the use of paraffin tulle-gras dressings. L-Mesitran®, a honey-based dressing, and by nature of biological nature, is highly effective in the treatment of surgical wounds.

Newsletter October 2007

The Netherlands NL - Have you seen our new Product Brochure? The new version is updated with all the latest information (the FDA approval for the Dressings, literature and case studies) and the layout has changed.

Croatia CR - The Zagreb based company Salvus d.o.o. will be promoting the full range of L-Mesitran products in Croatia (www.salvus.hr/)

Cyprus CY - The L-Mesitran product range is now available on Cyprus. The company Petros Loizou Ltd based in the capital Nicosia is responsible for the launch of the products. (www.ploizou.com)

Namibia NA - OmniMed Namibia (Pty) located in the capital city Windhoek of the Republic of Namibia is the partner for the L-Mesitran product range.The Namibian company is a 100% daughter of Triticum's partner in South Africa, OmniMed (Pty).

Turkey TR - The company Dunya Medical (www.dunyatip.com.tr) has signed a distribution agreement with Triticum for the Turkish market. Sales of L-Mesitran products in Turkey will commence this month.

We welcome all suggestions you have for improving this service to you. Please send your comments to info@triticum.org.

Triticum is very proud of the team effort by Triticum staff, the consultants QNET LLC and Barbara Debiase in obtaining the 510(k) clearance. It is a recognition by the world's leading authority in the field of the quality and efficacy of our honey based products.

August 9, 2007

Newsletter July 2007

NL - The Dutch veterinary clinic “De Raaphorst”, dedicated in the treatment of horses, reports on the benefits of L-Mesitran in their practice. One particular case study was documented with photographs and shows the results on an English thoroughbred. Dedicated website

UK - Our partner in the UK, UnoMedical, recently launched a Mesitran dedicated website: www.mesitran.co.uk. New case studies NL - Our website has been updated and you will find new case studies per product in the registered users segment. We welcome all suggestions you have for improving this service to you.