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Lea Grinberg, MD, PhD

Associate Professor

Neurology

Lea.Grinberg@ucsf.edu

Dr. Grinberg is a neuropathologist with interest in brain aging and associated disorders. Currently, Dr. Grinberg is an Associate Professor of Neurology and Pathology at the University of California in San Francisco, affiliated Professor of Pathology at the University of Sao Paulo – Brazil, visiting scientist at the Computer Department at the Lawrence Berkeley National Labs and head of the Human Validation Core for the NIH-funded Center Without Walls for Tau biology. Among Dr. Grinberg’s contributions to the dementia field are the identification of brainstem nuclei as the earliest structures affected in Alzheimer’s disease and the translation of these findings to diagnosis and treatment development; use of high-resolution histology and sophisticated computing tools for validating multimodal neuroimaging findings and participation in several international neuropathological consortia for establishing neuropathological criteria for neurodegenerative diseases and vascular dementia.

Primary Thematic Area:

Neurobiology

Secondary Thematic Area:

None

Research Summary:

Early stages of development of neurodegenerative diseases in humans. Dr. Grinberg employs a combination of well characterized postmortem human brain tissue, Neurons derived from IPSc lines and advanced methods of imaging processing.