Verknüpfte Pathways mit CDCA8 Proteine

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Human Cell Division Cycle Associated 8 (CDCA8) Interaktionspartner

These results were well correlated with the same gene expression pattern analysed in the thyroid tissue of the patient with BOREALIN-p.R114W. These studies open new avenues in the genetics of TD in humans.

These findings reveal a previously unrecognized but direct link between HP1 (zeige DEFA1 Proteine) and CPC localization in the centromere and illustrate the critical role of borealin-HP1 (zeige DEFA1 Proteine) interaction in orchestrating an accurate cell division.

important role for phosphorylation of Borealin at S219 in the proper progression through mitosis

Data show that INCENP (zeige INCENP Proteine) has an important role in stabilizing the chromosomal passenger complex, and that Borealin acts to promote binding of Survivin (zeige BIRC5 Proteine) to INCENP (zeige INCENP Proteine).

These findings indicate that Borealin plays a key role in liver development, regeneration, and tumorigenesis and suggests that Borealin could be a potential target for related liver diseases.

Borealin plays a crucial role in the early mouse embryonic development

Borealin/DasraB is essential for cell proliferation during early embryonic development, and its early embryonic lethality cannot be rescued by the loss of p53 (zeige TP53 Proteine)

CDCA8 Protein Überblick

Protein Überblick

This gene encodes a component of the chromosomal passenger complex. This complex is an essential regulator of mitosis and cell division. This protein is cell-cycle regulated and is required for chromatin-induced microtubule stabilization and spindle formation. Alternate splicing results in multiple transcript variants. Pseudgenes of this gene are found on chromosomes 7, 8 and 16.