The sales of the second-generation Chrysler 2000 Neon model started from its lineup in 2000 and ended with the 2005 model. The second generation of Neon was available only in the 4-door sedan body.

Only one engine was available - 2.0-liter SOHC, with 132 hp (92 kW) output in some large sales markets, including the United States. In addition, there was a special Magnum-configuration (active intake manifold) available for engine, which allows the engine to give out 150 hp (110 kW). Both motors have a cut-off nearly at 6762 rpm.

The second Chrysler 2000 Neon generation was more refined than the first-wave model. At the advertising campaign of the second-generation Neon, more than 1,000 changes were made as compared to an original version. Frameless doors have been replaced by the full frame, for instance. Some important improvements have been made in terms of noise, vibration and the rigidity of the body. New interior and increased body size added weight of the car. Engine DOHC (code designation in Chrysler ECC) has become more accessible.