Genome Property Definition Page

Accession

GenProp0954

Name

radical SAM-cylized peptide, Pep1357C family

Type

SYSTEM

Description

Pep1357C from Streptococcus thermophilus is a secreted modified peptide whose 9-amino acid mature form AKGDGWKVM is cyclized between residues 2 (Lys) and 6 (Trp), probably via a dehydrogenation catalyzed by the adjacent radical SAM enzyme. Similar peptides with the same core sequence KGDGW and pairing with a radical SAM enzyme occur elsewhere, such as Lactococcus lactis subsp. cremoris MG1363. The Pep1357C system probably provides signaling rather than bacteriocin activity.