HCG

For those that are TRT and taking hcg what dose of test and hcg do you take and how frequently do you inject each? I have the protocol from my doctor I'm just curious as to what others are using. The current protocol I'm on doesn't really seem to be working and looking to adjust it.

This study compared the effect of a single high dose of hCG (1500 IU) with that of the same dose administered in multiple small doses (300 IU, once daily for 5 days) on Leydig cell steroidogenesis. Administration of a single high dose of hCG to seven healthy men raised the mean plasma testosterone (T) level to peak levels 2.1 ± 0.2 (SEM) x the baseline value at 48 h. Thereafter plasma T decreased to below normal (0.7 ± 0.1 x baseline) 7 days after the injection. The mean 17-hydroxyprogesterone (17-OHP) level peaked at 24 h (2.5 ± 0.2 x baseline) and then also fell to a nadir value of 0.6 ± 0.2 x baseline on day 7. Reflecting the early accumulation of 17-OHP over T, the 17 OHP/T ratio reached its maximum (1.6 ± 0.1 x baseline) at 24 h at the same time when plasma estradiol [(E2) 4.4 ± 0.6 x baseline] and the ratio E2/T (2.7 ± 0.3 x baseline) achieved their maximal values. Administration of 1500 IU hCG in five divided doses of 300 IU daily increased the mean plasma T levels to peak value of 2.1 ± 0.2 x baseline at 5 days and the levels remained elevated thereafter. The response of T as reflected by the area under the curve was almost twice as great as in the single dose study (2844 ± 360 vs. 1647 ± 214). In contrast to the single high dose experiment, mean plasma 17-OHP levels in the divided dose protocol did not peak at 24 h but only gradually increased. As the increase of T exceeded the 17-OHP increase at almost all time intervals, no accumulation of 17-OHP over T occurred as in the single dose experiment. Instead the 17-OHP/ T ratio fell to a nadir value of 0.6± 0.1 x baseline on day 7. The initial E2 peak was absent in the divided dose protocol and the E2/T ratio only marginally increased. Considering both experiments together a close relation was found between the hCGinduced increases in E2 and 17-OHP (r = +0.88, P < 0.001), as well as the ratio 17 OHP/T (r = +0.64, P< 0.02). Multiple small dose hCG administration in contrast to a single high dose does not desensitize but rather enhances Leydig cell steroidogenesis, probably by preventing the early accumulation of E2 and thereby the steroidogenic enzyme suppression which occurs after massive doses of hCG.

This study compared the effect of a single high dose of hCG (1500 IU) with that of the same dose administered in multiple small doses (300 IU, once daily for 5 days) on Leydig cell steroidogenesis. Administration of a single high dose of hCG to seven healthy men raised the mean plasma testosterone (T) level to peak levels 2.1 ± 0.2 (SEM) x the baseline value at 48 h. Thereafter plasma T decreased to below normal (0.7 ± 0.1 x baseline) 7 days after the injection. The mean 17-hydroxyprogesterone (17-OHP) level peaked at 24 h (2.5 ± 0.2 x baseline) and then also fell to a nadir value of 0.6 ± 0.2 x baseline on day 7. Reflecting the early accumulation of 17-OHP over T, the 17 OHP/T ratio reached its maximum (1.6 ± 0.1 x baseline) at 24 h at the same time when plasma estradiol [(E2) 4.4 ± 0.6 x baseline] and the ratio E2/T (2.7 ± 0.3 x baseline) achieved their maximal values. Administration of 1500 IU hCG in five divided doses of 300 IU daily increased the mean plasma T levels to peak value of 2.1 ± 0.2 x baseline at 5 days and the levels remained elevated thereafter. The response of T as reflected by the area under the curve was almost twice as great as in the single dose study (2844 ± 360 vs. 1647 ± 214). In contrast to the single high dose experiment, mean plasma 17-OHP levels in the divided dose protocol did not peak at 24 h but only gradually increased. As the increase of T exceeded the 17-OHP increase at almost all time intervals, no accumulation of 17-OHP over T occurred as in the single dose experiment. Instead the 17-OHP/ T ratio fell to a nadir value of 0.6± 0.1 x baseline on day 7. The initial E2 peak was absent in the divided dose protocol and the E2/T ratio only marginally increased. Considering both experiments together a close relation was found between the hCGinduced increases in E2 and 17-OHP (r = +0.88, P < 0.001), as well as the ratio 17 OHP/T (r = +0.64, P< 0.02). Multiple small dose hCG administration in contrast to a single high dose does not desensitize but rather enhances Leydig cell steroidogenesis, probably by preventing the early accumulation of E2 and thereby the steroidogenic enzyme suppression which occurs after massive doses of hCG.

Awesome thanks for the information. I was doing 250iu 3 days a week per my doctor. Do you think doing a little over 100iu would be beneficial or is the amount to low per pin?

Appreciate it man! Just read through it. Some good information there. I had a question everywhere I read it says hcg helps with testicular size but I haven't noticed any size or fullness since starting. Should I try to get my dosage moved up? I've also read where guys coming off AAS doing 500iu for like 10 days in a row, then I could go back down to a normal dose.

Appreciate it man! Just read through it. Some good information there. I had a question everywhere I read it says hcg helps with testicular size but I haven't noticed any size or fullness since starting. Should I try to get my dosage moved up? I've also read where guys coming off AAS doing 500iu for like 10 days in a row, then I could go back down to a normal dose.

From personal experience it can take a month to see a restoration in size if I have been without hCG for a long time. I would stick to normal, lower dosing and let the body catch up since too much hCG only brings additional side effects.

From personal experience it can take a month to see a restoration in size if I have been without hCG for a long time. I would stick to normal, lower dosing and let the body catch up since too much hCG only brings additional side effects.

I got put on hcg in February and have had the same dose the whole time and no real change in size.

Mine have never regained full size when my HPTA worked correctly but there is still a noticeable increase from hCG. Some guys just don't respond well if their TRT dose is too high. I get better results in size when I stay at the low end of dosing.

You could try 500iu twice weekly but if you are primary, ie your testes are "broken", then hCG will not do much for you.

Abnormalities can result from disease of the testes (primary hypogonadism) or disease of the pituitary or hypothalamus (secondary hypogonadism). ... Secondary hypogonadism is usually associated with similar decreases in sperm and testosterone production.

Abnormalities can result from disease of the testes (primary hypogonadism) or disease of the pituitary or hypothalamus (secondary hypogonadism). ... Secondary hypogonadism is usually associated with similar decreases in sperm and testosterone production.