The A10 wasn't present initially in Euro Truck Simulator 2, because the region along it wasn't rendered. However, the Vive la France DLC, which features most of France not included in the base game, re-features this road.

As there are more connection roads and cities along the way, the number of junctions on the A10 also increased. Still, A10 passes no significant in-game cities except Paris and Bordeaux themselves. This makes the A10 somewhat similar to M4 and M5 motorways in United Kingdom.