Citation Manager

"Front Matter."
Final Report of The National Academies' Human Embryonic Stem Cell Research Advisory Committee and 2010 Amendments to The National Academies' Guidelines for Human Embryonic Stem Cell Research.
Washington, DC: The National Academies Press, 2010.

Please select a format:

Below are the first 10 and last 10 pages of uncorrected machine-read text (when available) of this chapter, followed by the top 30 algorithmically extracted key phrases from the chapter as a whole.Intended to provide our own search engines and external engines with highly rich, chapter-representative searchable text on the opening pages of each chapter.
Because it is UNCORRECTED material, please consider the following text as a useful but insufficient proxy for the authoritative book pages.

Do not use for reproduction, copying, pasting, or reading; exclusively for search engines.

OCR for page R1
Human Embryonic Stem Cell Research Advisory Committee
Board on Life Sciences
Division on Earth and Life Studies
Board on Health Sciences Policy
Institute of Medicine

OCR for page R1
THE NATIONAL ACADEMIES PRESS 500 Fifth Street, NW Washington, DC 20001
NOTICE: The project that is the subject of this report was approved by the Governing
Board of the National Research Council, whose members are drawn from the councils of
the National Academy of Sciences, the National Academy of Engineering, and the Institute
of Medicine. The members of the committee responsible for the report were chosen for their
special competences and with regard for appropriate balance.
This study was supported by The Ellison Medical Foundation. Any opinions, findings, con-
clusions, or recommendations expressed in this publication are those of the authors and do
not necessarily reflect the views of the organizations or agencies that provided support for
the project.
International Standard Book Number-13: 978-0-309-15600-4
International Standard Book Number-10: 0-309-15600-9
Additional copies of this report are available from the National Academies Press, 500 Fifth
Street, NW, Lockbox 285, Washington, DC 20055; (800) 624-6242 or (202) 334-3313 (in
the Washington metropolitan area); Internet, http://www.nap.edu.
Suggested citation: National Research Council and Institute of Medicine. 2010. Final Report
of the National Academies’ Human Embryonic Stem Cell Research Advisory Committee and
2010 Amendments to the National Academies’ Guidelines for Human Embryonic Stem Cell
Research. Washington, DC: The National Academies Press.
Cover: A cluster of motor neurons and neural fibers derived from human embryonic stem cells
in the lab of University of Wisconsin-Madison stem cell researcher and neurodevelopmental
biologist Su-Chan Zhang. These motor neurons were developed from one of James Thomson’s
original human embryonic stem cell lines. Copyright for the photograph is held by the Uni-
versity of Wisconsin’s Board of Regents.
Additional copies of this report are available from the National Academies Press, 500 Fifth
Street, NW, Lockbox 285, Washington, DC 20055; (800) 624-6242 or (202) 334-3313 (in
the Washington metropolitan area); Internet, http://www.nap.edu.
Copyright 2010 by the National Academy of Sciences. All rights reserved.
Printed in the United States of America

OCR for page R1
The National Academy of Sciences is a private, nonprofit, self-perpetuating society of distin-
guished scholars engaged in scientific and engineering research, dedicated to the furtherance
of science and technology and to their use for the general welfare. Upon the authority of the
charter granted to it by the Congress in 1863, the Academy has a mandate that requires it
to advise the federal government on scientific and technical matters. Dr. Ralph J. Cicerone is
president of the National Academy of Sciences.
The National Academy of Engineering was established in 1964, under the charter of the
National Academy of Sciences, as a parallel organization of outstanding engineers. It is au-
tonomous in its administration and in the selection of its members, sharing with the National
Academy of Sciences the responsibility for advising the federal government. The National
Academy of Engineering also sponsors engineering programs aimed at meeting national needs,
encourages education and research, and recognizes the superior achievements of engineers.
Dr. Charles Vest is president of the National Academy of Engineering.
The Institute of Medicine was established in 1970 by the National Academy of Sciences to
secure the services of eminent members of appropriate professions in the examination of
policy matters pertaining to the health of the public. The Institute acts under the responsibility
given to the National Academy of Sciences by its congressional charter to be an adviser to the
federal government and, upon its own initiative, to identify issues of medical care, research,
and education. Dr. Harvey V. Fineberg is president of the Institute of Medicine.
The National Research Council was organized by the National Academy of Sciences in 1916
to associate the broad community of science and technology with the Academy’s purposes of
furthering knowledge and advising the federal government. Functioning in accordance with
general policies determined by the Academy, the Council has become the principal operating
agency of both the National Academy of Sciences and the National Academy of Engineer-
ing in providing services to the government, the public, and the scientific and engineering
communities. The Council is administered jointly by both Academies and the Institute of
Medicine. Dr. Ralph J. Cicerone and Dr. Charles Vest are chair and vice chair, respectively,
of the National Research Council.
www.national-academies.org

OCR for page R1
Acknowledgments
The Committee acknowledges the input received from members of the
stem cell research and oversight communities and the speakers and partici-
pants in its meetings.
This report has been reviewed in draft form by individuals chosen for
their diverse perspectives and technical expertise, in accordance with proce-
dures approved by the National Research Council’s Report Review Commit-
tee. The purpose of this independent review is to provide candid and critical
comments that will assist the institution in making its published report as
sound as possible and to ensure that the report meets institutional standards
for objectivity, evidence, and responsiveness to the study charge. The review
comments and draft manuscript remain confidential to protect the integrity
of the deliberative process. We wish to thank the following individuals for
their review of this report:
George Q. Daley, Howard Hughes Medical Institute, Children’s
Hospital Boston, and Harvard Medical School
Fred H. Gage, Salk Institute for Biological Studies
Lawrence S.B. Goldstein, Howard Hughes Medical Institute and
University of California, San Diego
Bernard Lo, University of California, San Francisco
Geoffrey Lomax, California Institute for Regenerative Medicine
Gail R. Martin, University of California, San Francisco
P. Pearl O’Rourke, Partners HealthCare System, Inc., and Harvard
Medical School
Steven Peckman, University of California, Los Angeles
vii

OCR for page R1
viii Acknowledgments
Janet D. Rowley, University of Chicago
Huda Y. Zoghbi, Howard Hughes Medical Institute and Baylor
College of Medicine
Although the reviewers listed above have provided many constructive com-
ments and suggestions, they were not asked to endorse the conclusions or
recommendations, nor did they see the final draft of the report before its
release. The review of this report was overseen by Floyd E. Bloom, The
Scripps Research Institute. Appointed by the National Research Council,
he was responsible for making certain that an independent examination of
this report was carried out in accordance with institutional procedures and
that all review comments were carefully considered. Responsibility for the
final content of this report rests entirely with the authoring committee and
the institution.

OCR for page R1
Contents
Introduction 1
The 2010 National Academies’ Guidelines 4
The Future Role of the National Academies in Stem Cell Research
Oversight 5
2010 Amendments to the National Academies’ Guidelines for
Human Embryonic Stem Cell Research 7
APPENDIXES
A National Institutes of Health Guidelines for Research Using
Human Stem Cells 9
B Invited Participations at the August 7, 2009, Meeting of the
Human Embryonic Stem Cell Research Advisory Committee 17
C National Academies’ Guidelines for Human Embryonic
Stem Cell Research, Amended as of May 2010 19
D Committee Member and Staff Biographies 37
ix