..Initial treatment, performed at the Institut Gustave Roussy between 1987 and 1997, included in all patients a total thyroidectomy with central and ipsilateral en bloc neck dissection followed by radioactive iodine ablation...

..Treatment consists of surgical resection of the tumor followed by external beam radiation therapy centered on the cervical lymph nodes and Waldeyer's ring. Prognosis is good, with 5-year actuarial overall survival rate of 77%...

Medullary thyroid carcinoma arises in the absence of prolactin signaling

..1-6.5), and conversely the frequency of follicular histology was similar in male cases and in male controls (OR = 0.3, 95% CI: 0.1-1.4). The risks of recurrence and of thyroid cancer related death were similar in cases and in controls...

..These data identify several differentially expressed genes, such as FGD3, that may serve as potential targets of PPARgamma and as members of novel molecular pathways involved in the development of thyroid carcinomas...