Pentose phosphate pathway (article) | Khan Academy

Metabolism - Metabolism is the process your body uses to get or make energy from the food you eat. Food is made up of proteins, carbohydrates, and fats. Chemicals in your digestive system break the food parts down into sugars and acids, your body's fuel.

pentose phosphate pathway

TJ . In biochemistry, the pentose phosphate pathway (also called the phosphogluconate pathway and the hexose monophosphate shunt) is a metabolic pathway parallel to glycolysis that generates NADPH and pentoses (5-carbon sugars). While it does involve oxidation of glucose, its primary role is anabolic rather than catabolic. There are two distinct phases in the pathway. The first is the oxidative phase, in which NADPH is generated, and the second is the non-oxidative synthesis of 5-carbon…

Malignant cells rewire their pentose phosphate pathway and the Krebs cycle, to defend against reactive oxygen species generated in mitochondria. Potential new therapeutic target, Nature, 2016

Modern-day metabolism could have originated in 4-billion-year-old oceans. In a new study, researchers have found that some of the metabolic processes (glycolysis and the pentose phosphate pathway) that convert sugars into energy and molecular building blocks share many similarities with the chemical reactions that could have occurred in non-living four-billion-year-old Archean oceanic sediments. The work builds on a paper published by some of the same authors in 2014, in which they recreated…

pentose phosphate pathway

Glucose-6-phosphate Dehydrogenase is the committed step of the Pentose Phosphate Pathway. This enzyme is regulated by availability of the substrate NADP+. As NADPH is utilized in reductive synthetic pathways, the increasing concentration of NADP+ stimulates the Pentose Phosphate Pathway, to replenish NADPH