Not having Iupati, a four-time Pro Bowler, changes the dynamic of the starting offensive line and, of course, the depth level on it.

“The first six, I’m real comfortable (with),” Arians said, addressing the depth. “That second (group of) five or six guys, they’ve got a lot to prove.”

Veteran John Wetzel will move into Iupati’s spot at left guard for the time being. After Iupati’s exit Monday, second-year player Cole Toner jumped in to take first-team reps at guard, but for now, he’ll remain the team’s backup center behind A.Q. Shipley.

Arians should update Iupati’s injury situation following Wednesday morning’s walk-through at University of Phoenix Stadium.

The Cardinals travel to face the Atlanta Falcons Saturday at the brand-new Mercedes-Benz Stadium in their fourth of five preseason games. Kickoff is at 4:00 p.m. and pregame coverage starts at 12:30 on 98.7 FM, Arizona’s Sports Station.