: the secretion of a sebaceous gland; specifically: the foul-smelling pasty, cheesy sebaceous accumulation of desquamated epidermal cells and sebum that collects in moist areas like between the glans penis and the foreskin or around the clitoris and labia minora.

"And they say, 'Well, you'll have cheese if you're not
circumcised.' I like it! It's my cheese! Give it to me!"
Howard Stern, talking about smegma, on his radio show, 4/11/00