The researchers say the short-term risk of stroke after carotid artery stenting (CAS) is more than double for women when compared with the traditional carotid endarterectomy (CEA), in findings reported online May 9, 2011, in The Lancet Neurology; little difference was reported between the two procedures for men.

The study is part of the Carotid Revascularization Endarterectomy vs. Stenting Trial (CREST), one of the largest, randomized stroke-prevention trials in history. Virginia Howard, Ph.D., UAB associate professor of epidemiology and lead author, says this will help provide more information to patients and the doctors choosing between procedures.

Stroke, the third-leading cause of death in the nation, is caused by an interruption in blood flow to the brain by a clot or bleeding. The carotid arteries on each side of the neck are the major source of blood flow to the brain. The buildup of cholesterol in the wall of the carotid artery, called atherosclerotic plaque, is one cause of stroke.

CREST recruited 2,502 patients from 117 centers in the United States and Canada. The trial compared the use of the CEA and CAS procedures. Howard says use of CAS as an alternative to CEA is a relatively new procedure and primarily is used in patients for whom surgery is considered high-risk. The American Heart Association estimates that approximately 91,000 CEA procedures were performed in 2007, and 11,000 CAS procedures.

“The importance of these findings relate to the fact that CEA together now with CAS are the most frequently performed procedures to prevent stroke,” Howard explains.

Jenifer Voeks, Ph.D., UAB assistant professor of epidemiology and lead statistician on this study, says because women bear the greater burden from stroke, the gender aspect was important to explore.

“In previous trials of these procedures, women were under-represented. But in the CREST study, we have one of the largest numbers of women — 872 out of 2,502 participants or 35 percent,” Voeks points out.

Howard says further study is needed with additional gender-based subgroups with different risk factors to definitively answer whether sex is an important factor in the selection of revascularization techniques.