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Brady was jailed for the killings of John Kilbride, 12, 10-year-old Lesley Ann Downey and Edward Evans, 17, in 1966.

He went on to admit the murders of Pauline Reade, 16, and 12-year-old Keith Bennett.

Brady had been held at Ashworth High Secure Hospital since 1985 and died at 6.03pm on Monday.

A spokesman said the serial killer, who used the name Ian Stewart-Brady before his death, had been on oxygen.

Brady was not found dead in his room in the Merseyside unit, the spokesman said, but he was unable to confirm if anyone was with him when he died, adding: "Quite possibly. I don't know."

Terry Kilbride, the brother of victim John, said he will still have to deal with the "nightmare" Brady has left behind.

He told the Sun: "It's a lot to take in. It's been years and years of anguish and pain for us and the families of the victims.

"But nothing will change. He's dead but we will have to still live with the nightmare that he left behind.

"He's ruined our lives all these years and he'll still ruin it even though he's gone. I feel numb."

Mr Kilbride added that there were no other words to describe Brady apart from "a murderous psychopath".

The crimes of Brady and Hindley - who died in prison in 2002 - shocked the nation as details of how the pair snatched children off the street, abused and tortured them to death were recalled during their trial at Chester Assizes.

Brady escaped the hangman's noose as the death penalty was abolished just months earlier and was handed three life sentences.

In 2013 Brady asked to be moved to a Scottish prison so he could not be force fed, as he could be in hospital, and where he could be allowed to die if he wishes.

His request was rejected after Ashworth medical experts said he had chronic mental illness and needed continued care in hospital.

In February he was refused permission to launch a High Court fight to have the lawyer of his choice representing him at a tribunal where the decision would be reviewed.

Former police officer Norman Brennan, who represented the family of victim Lesley Ann Downey, told Newsnight about the "grief and torment" he saw on the faces of her mother and father.

He told the programme: "To know that your daughter was lost, alone and murdered and then actually her death was recorded, the grief can never ever be etched from your mind.

"Those two individuals, Myra Hindley and Ian Brady, they didn't just destroy five young children's lives.

"For their relentless appeals and false hopes that they gave the families for over 50 years destroyed all of the families as well, even to this day."