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ZytoLight ®SPEC FOXO1/PAX3 TriCheckTM Probe

The ZytoLight SPEC FOXO1/PAX3 TriCheckTM Probe is designed to detect translocations involving the FOXO1 (a.k.a. FKHR) gene and the PAX3 gene.

Alveolar rhabdomyosarcoma (ARMS) is characterized by two tumor-specific translocations:

t(2;13)(q36;q14.1) involving FOXO1 and PAX3

t(1;13)(p36.1;q14.1) involving FOXO1 and PAX7

PAX7-FOXO1 is less common but is associated with a better prognosis than PAX3-FOXO1 fusion. The translocations and their fusion genes represent highly specific genetic markers useful in the diagnosis and prognosis of ARMS.

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