Allison Janney, Catherine Keener and Oliver Platt co-star in the upcoming film directed by Julian Farino.

Hugh Laurie and Leighton Meester aren't strangers.

The two actors, who play an unlikely couple in the upcoming R-rated indie comedy The Oranges, appeared together in early episodes of Fox's House, where Meester played a patient of the week lusting over the cranky doctor (Laurie). In The Oranges, Laurie and Meester's secret relationship is revealed by a chance trip to a seedy motel that blows everything wide open for both their families. The film follows the aftermath of their affair -- and how it affects everyone around them.

THR reviewed The Oranges when it screened at last year's Toronto Film Festival,observing this: "Farino is good with actors, and in his corner he does have a gifted ensemble, who often manage to hit a sweet spot even in this mediocre material."