Jenkins was originally signed by Green Bay as a rookie free agent after the '03 draft. One year later, after an impressive NFL Europe season and strong training camp, landed a spot on the Packers' roster. From 2004 to November 2006, Jenkins was the backup for Kabeer Gbaja-Biamila, and took over the starting role the final month of the 2006 season. As the starter for the last month of games, he recorded a career-high 6½ sacks that year, including his first three-sack game vs. Detroit on December 17, 2006.

On February 26, 2007, Jenkins signed a four year, $16 million contract extension.[1] Jenkins batted down nine passes in 2007, the most by a Packers defensive lineman since the team began recording the statistic in 1980. He also finished 2007 with 26 total combined tackles and 1 sack.

In the 2008 season, the Packers decided to start Jenkins rather than Gbaja-Biamila for the second season in a row. He could only play four games though, before he suffered a torn pectoral muscle against the Tampa Bay Buccaneers on September 28, 2008. Two days later, he was placed on injured reserve. During his injury-shorted 2008 year, Jenkins had 13 tackles, 2.5 sacks, a pass defended, and a forced fumble.

In the 2009 season, Jenkins returned as a starting defensive end because the Packers had switched from a 4-3 to a 3-4 defense. Jenkins started all 16 games in 2009 with 32 tackles, 4.5 sacks, a pass defended, an interception, and 3 forced fumbles.

In the 2010 season Jenkins missed 5 games with a calf injury. He appeared in 11 games (started 6) with 18 total combined tackles, 7 sacks, and 1 pass defended. Jenkins was part of a major role of the Packers' 3-4 defense during their postseason run where they eventually won Super Bowl XLV, their first world championship in 14 years.

The Philadelphia Eagles signed Jenkins to a five-year, $25 million contract on July 30, 2011.[2] In 2011, he recorded 5.5 sacks, 24 hurries, and seven tackles-for-loss.[3] He agreed to a restructured contract on February 21, 2012,[3] with the new contract running through the 2014 season instead of the 2015 season.[4] On February 25, 2013, the Eagles declined his roster bonus, making him a free agent.[5]