This project was supported by the American Veterinary Medical Association; Association of Primate Veterinarians; Baylor College of Medicine; Broad Institute; Charles River Laboratories; Emory University; Genentech; GlaxoSmithKline; Indiana University; Janssen Research & Development, LLC; Japan Agency for Medical Research and Development; Johns Hopkins University; Johnson & Johnson/Janssen Pharmaceuticals; Massachusetts General Hospital; Massachusetts Institute of Technology (MIT); McGovern Institute for Brain Research at MIT; Medical College of Wisconsin; MedImmune; Merck and Co., Inc.; National Institutes of Health (Contract No. HHSN263201800029I; Task Order HHSN26300016); National Primate Research Centers; Novartis; Pfizer Inc.; University of Miami; University of Michigan; University of Pittsburgh; Wisconsin National Primate Research Center; and Yale University. Funding for this workshop was made possible, in part, by the U.S. Department of Agriculture through grant AP17AC000000G004 and the U.S. Food and Drug Administration through grant 5 R13 FD 005298-05. Views expressed in written workshop materials or publications and by speakers or moderators do not necessarily reflect the official policies of the U.S. Department of Health and Human Services; nor does any mention of trade names, commercial practices, or organizations imply endorsement by the U.S. government. This material is based on work supported by the National Science Foundation under Grant No. IOS-1639899. Any opinions, findings, and conclusions or recommendations expressed in this material are those of the authors and do not necessarily reflect the views of the National Science Foundation. Any opinions, findings, conclusions, or recommendations expressed in this publication do not necessarily reflect the views of any organization or agency that provided support for the project.

The National Academy of Sciences was established in 1863 by an Act of Congress, signed by President Lincoln, as a private, nongovernmental institution to advise the nation on issues related to science and technology. Members are elected by their peers for outstanding contributions to research. Dr. Marcia McNutt is president.

The National Academy of Engineering was established in 1964 under the charter of the National Academy of Sciences to bring the practices of engineering to advising the nation. Members are elected by their peers for extraordinary contributions to engineering. Dr. C. D. Mote, Jr., is president.

The National Academy of Medicine (formerly the Institute of Medicine) was established in 1970 under the charter of the National Academy of Sciences to advise the nation on medical and health issues. Members are elected by their peers for distinguished contributions to medicine and health. Dr. Victor J. Dzau is president.

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Acknowledgments

This Proceedings of a Workshop was reviewed in draft form by individuals chosen for their diverse perspectives and technical expertise. The purpose of this independent review is to provide candid and critical comments that will assist the National Academies of Sciences, Engineering, and Medicine in making each published proceedings as sound as possible and to ensure that it meets the institutional standards for quality, objectivity, evidence, and responsiveness to the charge. The review comments and draft manuscript remain confidential to protect the integrity of the process.

We thank the following individuals for their review of this proceedings:

Lynn C. Anderson, Consultant

Tamara Berdyyeva, Janssen R&D US

Kent Lloyd, University of California, Davis

Suzette D. Tardif, Southwest National Primate Research Center

Robert Wurtz, National Eye Institute

Although the reviewers listed above provided many constructive comments and suggestions, they were not asked to endorse the content of the proceedings nor did they see the final draft before its release. The review of this proceedings was overseen by Jeff Everitt, Duke University, and Stephen Barthold, University of California, Davis (emeritus). They were responsible for making certain that an independent examination of this proceedings was carried out in accordance with standards of the National Academies and that all review comments were carefully considered. Responsibility

for the final content rests entirely with the rapporteurs and the National Academies.

The support of the Roundtable on Science and Welfare in Laboratory Animal Use was vital to the planning and conduct of the workshop on Care, Use, and Welfare of Marmosets as Animal Models for Gene Editing–Based Biomedical Research. Federal sponsors are the National Science Foundation, the U.S. Department of Agriculture, and the U.S. Food and Drug Administration. Non-federal sponsorship was provided by the American Veterinary Medical Association; Baylor College of Medicine; Charles River Laboratories; Emory University; Genentech; GlaxoSmithKline; Indiana University; Johns Hopkins University; Johnson & Johnson/Janssen Pharmaceuticals; Massachusetts General Hospital; Massachusetts Institute of Technology; Medical College of Wisconsin; MedImmune; Merck and Co., Inc.; National Primate Research Centers; Novartis; Pfizer Inc.; University of Miami; University of Michigan; University of Pittsburgh; and Yale University.

The Roundtable on Science and Welfare in Laboratory Animal Use expresses deep gratitude to the members of the planning committee for developing an expansive and multifaceted workshop agenda and to the expert speakers who took part in the workshop’s discussions.

The marmoset, a type of small monkey native to South America, is a research model of increasing importance for biomedical research in the United States and globally. Marmosets offer a range of advantages as animal models in neuroscience, aging, infectious diseases, and other fields of study. They may be particularly useful for the development of new disease models using genetic engineering and assisted reproductive technologies. However, concerns have been voiced with respect to the development of new marmoset-based models of disease, ethical considerations for their use, the supply of marmosets available for research, and gaps in guidance for their care and management.

To explore and address these concerns, the Roundtable on Science and Welfare in Laboratory Animal Use hosted a public workshop on October 22-23, 2018, in Washington, DC. The workshop focused on the availability of marmosets in the United States and abroad; animal welfare and ethical considerations stemming from the use of wildtype and genetically modified marmosets; and standards of housing and care, dietary needs, and feeding requirements for marmosets in captivity. This publication summarizes the presentations and discussions from the workshop.

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