Zappetite 120 Caps by ThermoLife

Zappetite™ – The
Ultimate Appetite Suppressant™ is a unique and novel formula
containing new ingredients designed to eradicate appetite, burn
calories at rest, and increase thermogenesis with NO stimulant
side effects. There is no other formula that contains the revolutionary
combination of ingredients found in Zappetite.

OEA (Oleoylethanolamide) is a cannabinoid receptor agonist that
has been clinically proven to decreases appetite and body weight.
Hoodia Gordonii is a plant found in southern Africa containing
the P57 compound, which is known for its amazing appetite suppressing
activity. Simondslim™ contains Jojoba seed extract standardized
for Simmondsin, which has been demonstrated to dramatically decrease
appetite and body weight.

LotuSlim™ an ingredient exclusive to Zappetite is
a standardized extract of Lotus Leaf, which has been shown to liberate
fat stores and decrease body weight. Evodiamine is vanilloid receptor
agonist that utilizes the same receptor as the red pepper ingredient
capsaicin, which increases body temperature and caloric expenditure.
Angelica dhaurica is another ingredient exclusive to Zappetite contains
the first standardized extract of imperatorin, which has been shown
to act an oxidative uncoupler, increase fat burning hormones and decrease
fat storing hormones.

Sceletium tortuosum is yet another ingredient
exclusive to the Zappetite formula. Traditionally
know as the “feel good herb” because of its mood enhancing
effects sceletium has also been documented for its use in treating
relief of the stomach and tooth pains but it was used sparingly because
of its “side effect” of a loss of appetite! There is
no other formula currently in existence that possesses the appetite
crushing and thermogenic properties of Zappetite.
ZAPP your appetite away RIGHT NOW with Zappetite!!!

For more information on each of the ground breaking ingredients see
below:

Oleoylethanolamide

Oleyoethanolamide is a naturally occuring amide of oleic acid and
ethanolamine,synthesized in the human body primarily by upper part
of the small intestine especially when the meal is rich with fats.

It belongs in a family of naturally occurring fatty acid ethanolamides(FAEs),
present in both animal and plant organisms[1,2]. It received little
attention till it was found that a member of the same family, anandamide,
served as an endogenous ligand for cannabinoid receptors(3,4) the G-protein-coupled
receptors targeted by Ä9-tetrahydrocannabinol in marijuana [5,
6].

It was found that in the duodenum and jejunum of rats and mice, OEA
levels change in response to nutrient status- they are lower in food-deprived
than free-feeding animals, and return to normal values upon refeeding
[7]. This changes happen in the upper part of the small intestine-the
part most associated with food intake and feeding behaviour[8].OEA
levels in the rodent small intestine also display diurnal fluctuations.
They are higher during the daytime, when animals are satiated, and
lower during the night,when they are awake and actively feeding [9].
These findings led researchers conclude that OEA will affect appetite
and feeing behaviour. Indeed, studies in mice have shown OEA to suppress
appetite in a time and dosage dependent way[10-13]

Apart from it’s appetite suppressing abilities, OEA is also
a potent PPAR-á agonist. PPAR-á receptors are a class
of nuclear receptors that are also the target for antihyperlipidemic
drugs whose stimulation induces increased fatty acid catabolism, lower
blood lipid levels and lowered body weight gain[14,15]. In fact, OEA
is such a powerful PPAR-á agonist that it’s agonistic
action exceeds that of many other PPAR-á agonists[16]. Indeed,
apart from it’s antiorexiant actions, OEA has reduced weight
when administered chronically to both obese and lean mice.[17] All
current data suggests OEA as a very potent compound for the management
of appetite and treatment of obesity[16]

Hoodia Gordonii

Hoodia Gordonii is a cactus-like plant from South Africa, from the
large Milkweed family. Reports and interviews from South Africa natives
suggested that the plant could assuage both the feeling and “pangs” of
hunger that occurred during the long treks.[18] Animal studies compromised
on extracts from various parts of the plant have shown that Hoodia
Gordonii extract can reduce appetite, balance blood sugar levels and
promote weight loss, even in overfed animals[19], Animal safety studies
have not shown any deleterious side effects independent of the weight
loss itself. The putative active component in these sap extracts is
a trirhabinoside, known as P57AS3. ZAPPED is currently the only supplement
on the market containing Hoodia Gordonii extract that has been tested
positive for P57. The mechanism of action of P57 was studied in rats[19].
It was found that P57 increases ATP concentration in the hypothalamus(the
part of the brain that among other thing modulates feeding, body temperature,
sleep and hormonal release) by 50-150%. It has been found that following
long time hypo caloric diets, hypothalamic ATP levels drop by 40-60%,
which may very well lead to decreased hormonal production, sleep problems,
tiredness e.t.c. Summing up current evidence, apart from the appetite
suppression, P57 is very important from combating the side effects
following caloric-restricted diets.

The jojoba plant (Simmondsia chinensis) is a shrub cultivated in
arid and semiarid regions for its oil containing nuts. When the leftovers
of oil production (jojoba meal) were supplemented to animal food, a
profound reduction in food intake was observed. It was demonstrated
that simmondsin, a glycoside, was responsible for the appetite-reducing
effects of jojoba meal [20]. No major toxic effects have been noted
after long-term administration of low doses of simmondsin inducing
a sustained food intake and growth reduction in growing rats [21,22].
The food intake-reducing activity seems to be at least in a great part
mediated via the vagal nerve since vagotomy significantly reduces the
simmondsin-induced food intake inhibition [23]. Further studies on
rats have shown the anorectic effects to be dose-dependent, improve
with continued simmondsin administration, are greater for overfed rats
compared to underfed rats and can also induce taste aversion to craved
foods like a saccharin solution[24]. Simmondsin is powerful agent to
reduce craving for food.

Evodiamine, isolated from the dry unripened fruit of Evodia rutaecarpa
Bentham, is used for it’s analgesic,, antiemetic, astringent,
and antihypertensive effects in traditional Chinese Herbalism. [29].
Evodiamine also possesses antioxidant and anti-inflammatory activities[30]
as well as antianoxic action on oxygen-deprived brain cells[31].

The exact mechanisms of action of Evodiamine are many and still under
research. In a study in rats[32], evodiamine demonstrated potent activity
as a Cholecystokinine(CCK) agonist. The functions of cholecystokinin
(CCK) include stimulation of pancreatic enzyme secretion and inhibition
of gastric emptying[33]as well as suppression of food intake [33].
Thus, evodiamine can extend the satiating effect of food by slowing
food emptying and reduce overall food intake. Evodiamine also exerts
it’s fat loss actions through stimulation of the vallinoid receptors,
in the same way as capsaicin.[34] In a study performed on rats , Evodiamine
would induce heat loss and heat production at the same time and dissipate
food energy, preventing the accumulation of perivisceral fat and the
body weight increase.[34]

Angelica Dhaurica

Angelica dahurica Bentham et Hooker (Umbelliferae)is a perennial
herb distributed in the whole area of Korea, and its root has been
most frequently prescribed as a sedative and an analgesic in Chinese
medicine[35]. Angelica species have been traditionally used from the
middle ages for various ailments. From various phytochemical studies,
it has now been established that the majority of Angelica species contain
quite high amounts of biologically active coumarins, predominantly
simple- and furano- coumarins like umbelliprenin [36], bergapten, [37]
imperatorin [38], isoimperatorin [39], byakangelicin [40], etc., and
other active components. Angelica Dhaurica’s furanocumarines
imperatorin ,isoimperatorin , and oxypeucedanin are proven to have
potent acetylcholynesterase inhibitory activity. Acetylcholynesterase
is the enzyme that breaks up the neurotransmitter acetylcholine into
acetic acid and choline. Among other things, acetylcholine dilates
and relaxes blood vessels, which allows easier removal of fatty acids
from adipose cells and also increases c-GMP concentration in fat cells
by up to 350% in vitro.[41] Furanocoumarins such as oxypeucedanin hydrate,
bergapten, xanthotoxin, imperatorin and phellopterin can also activate
adrenalin-induced lipolysis. Imperatorin, oxypeucedanin hydrate and
phellopterin also activate ACTH-induced lipolysis. Byakangelicin, neobyakangelicin
and isopimpinellin strongly inhibite insulin-stimulated lipogenesis.[42]

Sceletium tortuosum

Sceletium Tortuosum Herba (kougoed) is a traditional herb found mainly
in the Western and Eastern Cape provinces, from Namaqualand to Montagu.
Sceletium species have been shown to contain at least 9 indole alkaloids,
belonging to one of three structural types. In S. tortuosum (1-1.5%
alkaloids) mesembrine appears to be most abundant (0.3% and 0.86% have
been reported, respectively, in leaf and stem). Mesembrenone and 4’-O-demethylmesembrenol
are also present. Tortuosamine, also isolated from S. tortuosum, represents
a second structural type in which the pyrrole ring is opened. Alkaloid
levels appear to fluctuate seasonally and may be highest in late spring/early
summer; this is the time when plants are traditionally gathered and
prepared for use [44]

There are many reports in the literature concerning the activity
and use of 'kougoed' by the indigenous peoples.' One of the most reputed “side
effects” (considered negative by the indigenous people) was loss
of appetite [45]. Other traditional uses include use for relief of
stomach and tooth pains, sedative, mood enhancement and thirst/hunger
suppression. [46]