Led using the multiple Principal Investigator model, the HSN is made up of research scientists and staff at research departments embedded within integrated HSN health systems, dedicated to public domain mental health research. The health care delivery systems represent diverse structures, and typically include an integrated delivery system, the ability to define patient populations, and access to electronic medical and administrative records. Current member organizations and research expertise are:

Health service outcomes for HIV-infected patients, including determinants of optimized multidisciplinary care for maximized HIV outcomes, medication adherence issues in these patients, and epidemiology of the disease, other sexually transmitted diseases and hepatitis