A control strategy which is based on the Catalytic Divided Wall Column (CDWC) for hydrolysis of methyl acetate (MeAc) is studied and a feasible control structure is obtained. The manipulated variables and controlled variables are selected and paired. Two kinds of disturbances are employed to test this control configuration and the result shows that a simple PI control scheme with three temperature loops can obtain reasonable control performance and maintains the desired purity of two products and stoichiometric balance between reactants.