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Abstract

By studiying a series of polyamine anthacoe conjugates we have discovered the optimum architecture to selectively delivery drug cargoes to cancer cells using the polyamine transport system. The homospermidine analogue the (4,3) and (5,4) analogues all gave enhanced selectivity in delivering an appended anthracene drug into cancer cells. this marks the first time that a triamine structure has been identified as enhancing delivery of an appended cargo.