The buzz: Red Raiders coach Kliff Kingsbury, who previously worked with Case Keenum at Houston and Johnny Manziel at Texas A&M, is developing two standout quarterbacks in freshmen Baker Mayfield (1,488 yards, 8 TDs) and Davis Webb (1,427, 11), who have been almost interchangeable behind center. The Sooners have the Big 12's top-ranked defense (293.4 ypg).

No. 12 UCLA at No. 3 Oregon

6 p.m. Saturday, ESPN

The buzz: The Ducks come in with the nation's second-ranked offense (643.1 yards per game) and a top Heisman Trophy candidate in quarterback Marcus Mariota, who is fifth in the country in total offense (363.4 ypg) and has 28 total touchdowns. The Bruins, coming off their first loss at Stanford, are a half-game behind Arizona State in the Pac-12 South and can't afford to fall too far back if they hope to earn a return trip to the conference championship game.

No. 21 South Carolina at No. 5 Missouri

6 p.m. Saturday, ESPN2

The buzz: Amazingly, the road to the SEC East title runs through Columbia, Mo. A victory over the Gamecocks would give the Tigers essentially a three-game lead. Both teams are without their starting QBs. South Carolina's Connor Shaw injured his left knee in a loss to Tennessee, while redshirt freshman Maty Mauk is filling in for Missouri's James Franklin (separated shoulder).

Penn State at No. 4 Ohio State

7 p.m. Saturday, WLS-Ch. 7

The buzz: Despite the nation's longest winning streak (19), the Buckeyes are losing traction in the rankings and need to dominate this game to help their national title case. Ohio State leads the Big Ten in scoring (45 ppg) and is third in offense (493.1 ypg), while Nittany Lions freshman Christian Hackenberg leads in passing (278.7 ypg).

No. 6 Stanford at No. 25 Oregon State

9:30 p.m. Saturday, ESPN

The buzz: Beavers QB Sean Mannion, the national leader in total offense (414.3 ypg) and touchdown passes (29), is becoming a dark-horse candidate in the Heisman race. He'll be tested by the Cardinal defense, which shut down Brett Hundley and the prolific UCLA offense last week.