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Fig.1. Comparisons of the relative amount of carbohydrate residues on each sera TgAb from patients with different thyroid diseases. Results

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Fig.2. Comparisons of the relative amount of carbohydrate residues on each serum TgAb from Hashimoto ’ s thyroiditis patients with different thyroid functional status. Results

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Fig.3. The correlation between the relative amount of carbohydrate residues on each TgAb and TgAb IgG in all the patients (n = 109). Results

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The levels of fucosylation and sialylation on TgAb varied in different thyroid diseases. We speculated that TgAb with lower content of core fucose and terminal sialic acid might have stronger ability to participate in ADCC in HT. Terminal galactose content of IgG does not affect ADCC but complement dependent cytotoxicity (CDC). Discussions

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There were no significant differences in the levels of glycosylation on each TgAb among the three HT subgroups. The levels of glycosylation on TgAb might not represent thyrocyte hyperplasia but merely reflect the capacity of inducing thyroid destruction Discussions

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1. Glycosylation of sera TgAb varied in the patients with different thyroid diseases. 2. The levels of glycosylation of TgAb might decrease with increasing TgAb levels. Conclusions

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Acknowledgements Supported by Beijing Natural Science Foundation Beijing Nova Program Program for New Century Excellent Talents in University Sector funds of ministry of health (no ). Thank you for your attention!!

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Fig.1. The biotinylated lectins binding to Tg in different oxidation time with sodium periodate.

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Fig.2. TgAb lgG binding to thyroglobulin with a serial dilution (diluted 1: :800) in different oxidation time with sodium periodate.