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The authors showed that JNK1-deficient mice had a significantly higher survival rate than wild-type control mice in response to Candida albicans infection, and the expression of JNK1 in hematopoietic innate immune cells was critical for this effect. [Nat Med]
Abstract

Through the use of regulatory T cells (Treg cells) induced by transforming growth factor-β, scientists identified the transcription factor musculin as being critical for the development of induced Treg cells by repression of the T helper type 2 (TH2) transcriptional program. [Nat Immunol]
Abstract

The authors provide an overview of natural killer T (NKT) cells in the immune system, discuss CD1 molecules and lipid antigen presentation, and describe the interaction of the CD1d–NKT cell network with gut microbiota and its effect in modulating the activity or levels of NKT cells, which might in turn influence atherosclerosis. [Nat Rev Cardiol]
Abstract

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Aurinia Pharmaceuticals Inc. announced that it has selected Worldwide Clinical Trials as its Clinical Research Organization (CRO) for the AURORA Phase III study of volcosporin for the treatment of active lupus nephritis. [Aurinia Pharmaceuticals Inc.]
Press Release

X4 Pharmaceuticals announced dosing of the first patient in a Phase I/II study of X4P-001, the company’s lead CXCR4 inhibitor, in patients with advanced clear cell renal cell carcinoma. [X4 Pharmaceuticals]
Press Release

Neovia Oncology has enrolled its first patient into a Phase I clinical trial for its lead cancer drug NEV-801, a novel, multi-inhibitor drug able to enhance immunotherapy response in patients with advanced drug-resistant cancers. [Neovia Oncology]
Press Release

Makers of genetically engineered products have long been on the lookout for changes in U.S. regulations. The system that divvies up the safety review of these products between the Food and Drug Administration, Environmental Protection Agency, and U.S. Department of Agriculture is in the middle of a years-long overhaul, in part to accommodate modern gene-editing technologies such as CRISPR. And a set of new proposals released last week offers hints about what those agencies still hope to change. [ScienceInsider]
Editorial

A newly minted leader with no experience governing at home or establishing policy abroad now oversees the United States’ vast diplomatic enterprise. US President Donald Trump has a deep bench of scientific and technical expertise to tap across multiple government agencies — but it is not clear that he will use it. [Nature News]
Editorial