A case of giant cell lesion as an initial feature of primary hyperparathyroidism is presented. A 55-year-old woman reported with a complaint of swelling and occasional pain in the upper-left posterior region with 2 months’ duration. The diagnosis of a giant cell lesion with primary hyperparathyroidism was confirmed on the basis of radiological, biochemical, and histopathological investigative procedures. (Quintessence Int 2007;38:529.e342–347)

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