SLC2A10 is a member of the facilitative glucose transporter family, which plays a significant role in maintaining glucose homeostasis. a full-length SLC2A10 cDNA encoding a 541-amino acid protein. SLC2A10 shares between approximately 28% (SLC2A3) and 34% (SLC2A8) amino acid sequence identity with other members of the facilitative glucose transporter family. SLC2A10 has 12 transmembrane domains, with a hydrophilic intracellular loop between helices 6 and 7, together with a large extracellular loop (containing a potential N-linked glycosylation site) between helices 9 and 10. Northern blot analysis of adult tissues detected a major 4.3-kb transcript with highest levels of expression in liver and pancreas and lower levels of expression in all other tissues examined.