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A j-pouch, or ileal pouch reconstruction, is a surgery that is used for ulcerative colitis patients, and is usually completed in two steps.

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Tuesday, March 11, 2008

July 18, 2007 -- Two new studies show that a new drug called Cimzia may ease symptoms of Crohn's disease.

Cimzia hasn't been approved by the FDA yet. Patients would give themselves injections of the drug, which targets an inflammatory chemical called tumor necrosis factor (TNF) alpha.

The two new studies, published in The New England Journal of Medicine, highlight Cimzia's clinical trials in Crohn's disease patients.

Cimzia vs. Placebo

The first study included 662 people with moderate to severe Crohn's disease. Half of the patients got Cimzia shots every two weeks for the first month, and then one shot per month for the rest of the six-month study.

For comparison, the other patients got sham shots (placebo) on the same dosing schedule. Patients in both groups kept diaries about their Crohn's symptoms and got regular checkups.

At the end of the study, Crohn's symptoms had eased for 23% of the Cimzia group, compared with 16% of those in the placebo group.

Cimzia had a "modest improvement in the response rate, as compared with the placebo," write the researchers. They included William Sandborn, MD, of the gastroenterology and hepatology division of the Mayo Clinic in Rochester, Minn.

However, patients taking Cimzia weren't more likely to achieve remission from Crohn's disease than those taking the placebo.

Cimzia: Maintaining Results

The second study focused on maintaining improvements in Crohn's disease symptoms over six months.

The researchers included Stefan Schreiber, MD, of the Hospital for General Internal Medicine at Christian Albrechts University in Kiel, Germany.

They studied 668 people with moderate to severe Crohn's disease.

The study lasted for six months. For the first month, all of the patients got Cimzia shots every other week. During that time, Crohn's symptoms improved for nearly two-thirds of the patients.

After that, Schreiber's team focused only on the patients who had shown improvement with Cimzia treatment.

The researchers put the patients on a maintenance plan -- a monthly shot of Cimzia or a placebo.

Patients taking Cimzia were more likely to maintain their improvement in Crohn's symptoms during the six-month study, compared with those taking the placebo.

Cimzia Side Effects

Infection risk may be higher with anti-TNF drugs.

In Schreiber's study, serious infections (including one case of tuberculosis) occurred in 3% of the Cimzia group, compared with less than 1% of the placebo group.

In Sandborn's study, serious infections were reported in 2% of Cimzia patients and less than 1% of those taking the placebo shots.

Both studies were funded by UCB Pharma, which makes Cimzia. Both sets of researchers note financial ties to various drug companies, including UCB Pharma.

Cimzia: Second Opinion

"If the drug is ultimately approved, where will it fit into current treatment strategies?" asks editorialist James Lewis, MD, MSCE, in The New England Journal of Medicine.

Lewis works at the University of Pennsylvania's medical school. He writes that ideally, researchers would do studies that directly compare anti-TNF drugs for Crohn's disease.

"Unfortunately, it is unlikely that such comparative trials will be conducted," writes Lewis.

Lewis notes financial ties to various drug companies, but not to UCB Pharma.

If you or a loved one is living with Crohn’s, find help and support on WebMD’s Crohn’s and Colitis Support Group message board.

This is the time to get inspired. Having ulcerative colitis doesn't mean life is over. Sure, there will be challenges, but with the right guidance and support, there's no reason you can't get right out there!

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Do you have a story to tell?Of course you do. Everyone with inflammatory bowel disease has a story of overcoming illness and adversity.If you have ulcerative colitis, you can tell your story and become a member of our support group. Just write your story, suggestions, anything you want to share with other UC patient's .Please send us your personal story, it help others coping with the same issues.Email us at:anscreativity@gmail.com. Once we will post it , will send you the link.

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Welcome to the first Blog on the web dedicated to the Ileo-anal anastomosis, or "J-Pouch" operation

This Blog is created by Miss Anshu Gupta(Ulcerative Colitis Patient, Operated for J-Pouch Surgery) by the team of expert Liver Transplant & Gastrointestinal Surgeons,Dr Subash Gupta, Dr Samiran Nundy, Dr A.S Soinof SGRH New Delhi, India, in Dec. 2005.Join me for support and information regarding this procedure. I hope to bring you the most information on the web as you plan for the operation or are dealing with life after suffering with Ulcerative Colitis, Cancer or familial polyposis.

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