Like many East Tennessee counties, Bledsoe County opposed secession on the eve of the Civil War. In Tennessee's Ordinance of Secession on June 8, 1861, the county's residents voted against secession by a margin of 500 to 197.[5] General James G. Spears, a resident of Bledsoe, served as a vice president at the pro-Union East Tennessee Convention in May and June 1861, and fought for the Union Army in the war.[6]

There were 4,430 households out of which 31.30% had children under the age of 18 living with them, 61.50% were married couples living together, 9.10% had a female householder with no husband present, and 25.20% were non-families. 22.10% of all households were made up of individuals and 9.20% had someone living alone who was 65 years of age or older. The average household size was 2.53 and the average family size was 2.94.

In the county, the population was spread out with 23.10% under the age of 18, 8.40% from 18 to 24, 31.30% from 25 to 44, 25.80% from 45 to 64, and 11.40% who were 65 years of age or older. The median age was 37 years. For every 100 females there were 121.00 males. For every 100 females age 18 and over, there were 121.30 males.

The median income for a household in the county was $28,982, and the median income for a family was $34,593. Males had a median income of $26,648 versus $20,639 for females. The per capita income for the county was $13,889. About 14.90% of families and 18.10% of the population were below the poverty line, including 21.00% of those under age 18 and 23.20% of those age 65 or over.