On June 2, 2006, the band took part in a short interview and then played a free CD release show at The Edge 102.1 (CFNY-FM) and then on June 6 Birthing the Giant was released into major record stores. The album includes guest vocals by George Pettit of Alexisonfire. On June 7, 2006 they hosted All Things Rock, a show on MTV Canada, and had their own video played at the end of the show.[12]

Bass player Andrew McCracken left to concentrate on his design company Doublenaut. His spot was filled in by Jason Bailey (former member of Figure Four and Shattered Realm) for most of 2007. However, Bailey was then replaced by Jaye R. Schwarzer (formerly of Left Behind, Hope to Die, Minesweeper, and Kover) as he wanted to focus on being a graphic designer; he still designs artworks for Cancer Bats and remains friends with Liam Cormier.

Cormier performing at a Cancer Bats show in Barcelona in June 2008.

The band released their second studio album called Hail Destroyer on April 22, 2008. The album features guest vocals by Wade MacNeil of Alexisonfire and Black Lungs, Tim McIlrath of Rise Against and Ben Kowalewicz of Billy Talent. The release was held at the Mod Club in downtown Toronto with Liam Cormier not only singing for Cancer Bats, but also performing drums for Black Lungs. On May 17, 2008, Cancer Bats were put on the cover of Kerrang!, a publication which gave their album Hail Destroyer a KKKKK review (highest possible) as well as a 5k Live review on their headlining UK tour. Cancer Bats were also nominated for 2008 Album of the Year for the 2008 Kerrang! awards.

Cancer Bats returned to the UK in 2009, after Swedish melodic metal band In Flames cancelled their April 2009 concerts, on which Cancer Bats were slated to be main support.[14] The band is also featured on Gallows' latest album Grey Britain on May 2.[13] In August 1, Cancer Bats played a slot at the premier showing of the Sonisphere festival and at the inaugural Hevy Music Festival. Also in 2009, Cancer Bats appeared in an episode of the documentary series City Sonic, reflecting on their time at the Adrift Clubhouse. In October and November, the band supported Billy Talent on their UK and European tour. During the tour they performed several new songs from their third album, including "Darkness"[15] and "Scared to Death".[16]

In late 2011, Cancer Bats toured Canada as a Black Sabbathtribute band under the moniker "Bat Sabbath".[20] The concept stated at Sonisphere Festival on July 10, 2011 when the band was asked to do an after-party show, on top of their initial set in the afternoon, in the tent stage after Slipknot played the main stage. The dates they performed at for the Sonisphere were the last dates they did before they stopped to work on a follow up to their third studio album.[21] After the performances at the various Sonisphere dates they did a 12 date Canadian tour in December 2011 centred around the Black Sabbath tribute.[22][23]

The band announced that the fourth album is titled Dead Set on Living,[24] which was released in April 16, 2012. Cancer Bats had stated that they desired to create a more "upbeat" follow up to their previous album Bears, Mayors, Scraps & Bones.[21]

The band's influence steered away from the "traditional hardcore record" and took a wide variety of influences from rock bands including Fleet Foxes. Liam Cormier when asked about his influences stated: "In a lot of ways we get really inspired by non-metal bands. For me, I find I really like looking at other things because I just don't want to make a traditional hardcore record lyrically. So for me, I listen to a lot of indie rock and I've been getting super psyched on a lot of that, like the new 'Helplessness Blues' by Fleet Foxes".[25]

On January 24, Distort Entertainment released the video for the single "Old Blood" online.[26] On March 7, 2012 Cancer Bats released a second music video in promotion of the album for the song "Road Sick".[27] Cancer Bats' announced that they would play several release shows on April 21, 2012. They have aimed to play six shows at five different venues across London, United Kingdom, in the shape of a pentagram in promotion of their fourth album.[24]

Cancer Bats' fifth studio album, Searching for Zero, was released on March 10, 2015. The band have posted the song "Arsenic" off the album on YouTube. A post on their official site stated the reason for the band being silent for quite some time: "For those of you who didn’t know, the reason we’ve been gone for so long was to craft our 5th full length! We worked our asses off making a serious banger that we could all party the fuck out of! We even went down to Venice Beach to record with Ross Robinson so it would sound extra dope…..which it does!"[citation needed]

They have also released five singles and EPs. Cancer Bats was the first EP by the band. It was produced and engineered by guitarist Scott Middleton. This EP was sold at all the live shows leading up until the release of Cancer Bats' first album Birthing the Giant and later repressed as a 7" record by Tragicomedy Records. This Is Hell / Cancer Bats was a limited release 7" vinyl EP shared with the This Is Hell band. Each band contributes one new song, and one cover song of the other band.[32][33]Cancer Bats / Rolo Tomassi was a split release with the band Rolo Tomassi in 2009. The songs were recorded and released at the beginning of 2009 on to a limited amount of black 7" vinyl through Hassle Records. The vinyl is strictly limited to 300 copies and was only available through each artist's shows, and Rolo Tomassi's 'Subs Club' 7" (2009).[34] Cancer Bats also released the Tour EP (2009).[35] In March 2, 2010, Cancer Bats released the Sabotage EP.[36] Its name is derived from their cover of the Beastie Boys' song "Sabotage". The band has also shot a music video for the song that premiered on February 16 through the band's MySpace page.