In the NFL's Week 4, you may not want to go near Tony Romo and the Cowboys. (GARY HERSHORN/REUTERS)

From the best NFL games to bet this weekend, to the ones you should steer clear of, check out Sean Brennan's guide to get you through the weekend a winner. Then check out how the rest of our crew of pigskin experts see this weekend's action as they pick against the spread.

GIANTS at EAGLES 8:20 p.m., Ch. 4, Eagles by 2, 47½

BRENNAN'S BUZZ: The Giants are coming off a 10-day respite after dismantling the Panthers a week ago, and during that time Big Blue has seen RB Ahmad Bradshaw (neck) and WR Hakeem Nicks (foot) heal enough to return while the Cardinals roughed up the Eagles like a tourist in a biker bar. So far Michael Vick has defied the odds and is somehow still standing upright behind an offensive line that could be indicted for accessory to assault. Vick already has been sacked nine times in three games and has tossed six INTs. That 66.3 passer rating won't exactly put the fear of God into Giants' D either. In fact, Philly's offensive line should have been using this week to get its affairs in order what with Justin Tuck, Jason Pierre-Paul and Osi Umenyiora arriving Sunday night. In the meantime, Big Blue is having no such problems on offense. Eli Manning has thrown for 531 yards and three TDs in just his last five quarters and will have a plethora of play things to choose from what with the emergence of Ramses Barden and Andre Brown. Philly has two one-point victories and a blowout loss. Sunday night, make that two blowout losses.

BRENNAN'S BUZZ: The Niners spent the week leading up to this game trapped in Youngstown, Ohio, rather than travel back to California from their game in Minnesota last Sunday and make another cross-country trip to New York. A week in Youngstown is considered by many, myself included, as cruel and unusual punishment, and Amnesty International should be alerted. But that's what Jim Harbaugh saw as fit punishment for losing to the Vikings. Now Harbaugh's boys get first crack at a Jets team still adjusting to football life without Darrelle Revis. The Niners come into the game winners of nine of 11 in the all-time series while winning six of the last seven and those numbers aren't likely to change Sunday as San Fran unleashes Frank Gore (264 yards, 5.9 per carry) on a Jets D that is allowing 148.7 rushing yards a game. Toss in the work of game manager/QB Alex Smith (5 TDs, 1 INT) and a cadre of receivers in Vernon Davis, Michael Crabtree and Mario Manningham, and well, it's not going to be easy being Green this week. Added motivation for the Niners: If they lose this one, word is they spend a week in Camden.

IF I WERE A BETTING MAN: Niners and the under.

SAINTS at PACKERS 4:25 p.m., Packers by 7½, 53½

BRENNAN'S BUZZ: Thank the Lord the replacements are gone. Now if we can only find out what happened to the Packers' once dynamic offense. Through three games, the Pack has yet to top the 23-point mark, which was more often than not their halftime total last season. This would appear to be the week to get that offense untracked as Aaron Rodgers faces a Saints defense that has allowed no less than 27 points in any of its three losses, with the Skins torching it for 40 on Opening Day. The Saints have allowed 1,432 yards through three games, an average of 477.3 per game. (I've seen Pop Warner teams with stouter defenses). "We haven't been 0-3 for a very long time," Saints interim coach Aaron Kromer said. "We don't know how it feels." Tune in next week when he says the same things about being 0-4.

IF I WERE A BETTING MAN: Saints and the over.

PANTHERS at FALCONS 1 p.m., Falcons by 7, 48½

BRENNAN'S BUZZ: After picking on the poor AFC West through the first three weeks — and getting three wins for their troubles — the Falcons finally see their first division game. The Falcons are 3-0 for the first time since 2004, and as much credit as the Matt Ryan-led offense seems to get for its success, let's not shortchange the Dirty Bird defense. The Falcons already have 11 takeaways this season, which you might want to keep in mind here as the Panthers are a robust 0-11 whenever Cam Newton logs at least one turnover. Chances are fairly good that Cam will oblige here as the Panthers are 4-13 all-time in Atlanta. Just for fun, watch Carolina CB Josh Norman try to contain Julio Jones. Norman is the same player whom Ramses Barden torched for 138 yards last week.

IF I WERE A BETTING MAN: Falcons and the under.

PATRIOTS at BILLS 1 p.m., Patriots by 4, 51

BRENNAN'S BUZZ: Did you know the last time the Patriots were below .500 was after opening day 2003, when they lost to the Bills? That was 145 games ago. By sometime around 4 p.m. Sunday, all order should be restored to the Patriots universe. With the uncertain statuses of both Fred Jackson (knee) and C.J. Spiller (shoulder), a lot will be on the shoulders of Ryan Fitzpatrick. That's not a good place for the Bills' fortunes against the Pats as Fitz has thrown 11 INTs in his last four games vs. New England. The Pats have won 17 of the last 18 in the series and do you think there is even a chance of a third straight New England loss?

IF I WERE A BETTING MAN: Patriots and the under.

VIKINGS at LIONS 1 p.m., Lions by 5, 47

BRENNAN'S BUZZ: A week after becoming the first team in NFL history to give up five touchdowns of 60-plus yards, the Lions return home, lick their wounds and look to get healthy again against Christian Ponder. Ponder had a strong performance in the Vikes' surprising win over the Niners last week, but he now returns to the scene of the crime of his worst performance as a pro. Last season in Detroit, Ponder threw three INTs, had four turnovers in all and was benched for the immortal Joe Webb. Detroit might be without Matthew Stafford, but Shaun Hill is one of the better backups in the league.

IF I WERE A BETTING MAN: Lions and the over.

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Expert staff picks, NFL Week 4 (Part 2) (New York Daily News)

TITANS at TEXANS 1 p.m., Texans by 12½, 44½

BRENNAN's BUZZ: Chris Johnson's photo has been splashed on milk cartons all over the Greater Nashville area as Titans fans wonder what ever happened to their running back. Johnson has managed just 45 yards in three games (quick math, that's 15 a game) and totes a paltry 1.4 yards/carry average into Houston. The Titans can ill afford a slow start as Houston is the master of the quick break from the gate, outscoring its opponents, 62-14, in first halves this season. Tennessee's D has given up 34, 38 and 41 points in three games, and with Houston looking to go 4-0 for the first time in franchise history, don't expect QB Matt Schaub to ease up on the throttle.

IF I WERE A BETTING MAN: Texans and the over.

DOLPHINS at CARDINALS 4:05 p.m., Cardinals by 6, 39½

BRENNAN'S BUZZ: The surprising Cardinals have staked their turnaround on a smothering defense and an improving running game to offset what was a muddled quarterback picture. But with three wins under his belt this season while Week 1 starter John Skelton nursed his injured ankle, Kevin Kolb has done enough to keep the chains moving, throwing for four TDs and nary an INT. The Cardinals are 3-0 for the first time since 1974 (circa: Jim Hart, Mel Gray, Terry Metcalf) and have not allowed more than 18 points in any game. Reggie Bush's (knee) uncertain status tilts the odds in Arizona's favor even more.

IF I WERE A BETTING MAN: Cardinals and the under.

BENGALS at JAGUARS 4:05 p.m., Bengals by 2½, 42½

BRENNAN'S BUZZ: This week Madonna promised that if Obama is re-elected, she'll do a striptease on stage. Two things: that just solidified my vote for Mitt and, two, about the only thing more objectionable than a naked over-the-hill no-talent songbird would be a Bengals loss to the punchless Jaguars. The Bengals are in the soft part of their schedule here and it's time to start packing on the wins. This season Cincy has turned into the Big-Play Bengals as six of their nine TDs have been for more than 40 yards. However, the Bengals are a little leaky against the run (giving up 155 rush yards a game) to which Maurice Jones-Drew says, "If I run for over 125 yards, I'll do a striptease in the end zone."

IF I WERE A BETTING MAN: Bengals and the under

SEAHAWKS at RAMS 1 p.m., Seahawks by 2½, 38½

BRENNAN'S BUZZ: The Seahawks have won 13 of the last 14 meetings in the series. Had the replacement refs and Golden Tate been around for that one loss, however, they would have been a perfect 14-for-14. The Rams' woeful offensive line has led to Sam Bradford being sacked 12 times already this season, including six times last week. The Rams have trouble running the ball, the Rams have trouble protecting Bradford and, well, against Seattle's rather formidable defense, the Rams are just going to have trouble period. Though wouldn't it be nice to see the Rams win on a Hail Mary?

IF I WERE A BETTING MAN: Seahawks and the under.

BEST OF THE RESTCHARGERS at CHIEFS 1 p.m., Chiefs by 1, 44½ IF I WERE A BETTING MAN: Chargers and the over

RAIDERS at BRONCOS 4:05 p.m., Broncos by 6½, 48½ IF I WERE A BETTING MAN: Broncos and the over

REDSKINS at BUCS 4:25 p.m., Bucs by 2½, 47½ IF I WERE A BETTING MAN: Skins and the over