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Author
Topic: NucleomaxX (Read 7420 times)

There's been quite a bit of interest in this and speculation. I guess the form in which uridine is being studied in people with HIV is in this supplement from Europe called NucleomaxX -- that's a sugar cane extract. The rationale behind using uridine is that one side effect of mitochondrial damage might be a reduction in nucleoside production, and by giving uridine, which is a nucleoside, you're kind of, in a way, overcoming that deficiency that's created secondary to mitochondrial toxicity, and by overcoming this deficiency, perhaps you could reverse some of the lipoatrophic effects of the nucleosides.

So that's the theory. You know, theory and practice are often widely separated. The only study that I'm aware of to date that's produced really well controlled data was a small study that was reported by Jussi Sutinen from Helsinki, and this was reported at the lipodystrophy meeting that was held in Dublin last fall, and it was a very small study, but it was well done, randomized, double-blind placebo-controlled. I think there were about 10 subjects per group, and they were randomized to get this supplement, NucleomaxX, or a placebo for three months. In that three-month period, the subjects who were randomized to receive NucleomaxX had an increase in limb fat, combined arm and leg fat, that totaled [about 900 grams]. That's [almost two pounds] of an increase in limb fat over three months, and that magnitude of increase is greater than what had been seen in so-called switch studies and also what's been seen in the studies using the so-called glitazones.

So it's very promising. A couple of big caveats: First of all, it was a very small study and obviously needs to be studied further in larger groups of subjects. The other thing is that in addition to an increase in limb fat, there was an increase in intra-abdominal fat, and so, in the patients who received NucleomaxX. So it's not clear whether the effect of this supplement was to just put on fat all over non-selectively or whether this will wind up being something that can specifically reverse lipoatrophy, the loss of subcutaneous fat, but I think it's intriguing and definitely warrants further study.

Written by:

About Kathleen Mulligan, Ph.D.

Dr. Mulligan helped organize the first International Workshop on Adverse Drug Reactions and Lipodystrophy in HIV, the only medical conference focused entirely on body-shape changes in people with HIV. She is one of the key researchers working on trying to understand and treat the disorder. After receiving a Ph.D.

1. The stuff is horrid to taste. No matter how much we tried to cover it the unique and nauseous taste still came through. Like a shot of yager that you'd swish instead of downing; extremely bitter.

2. Orders and shipping was interesting. Had to order it from England. Was a bit nervous doing the credit card transaction as it seemed I was ordering it from some sort of curiosity shoppe. No problems resulted from transactions, however. Oddly, when the parcel (box) arrived it had a shipping address from inside US. Wish I would have saved that address. Just found it interesting that I couldn't buy it in the US but apparently it's stocked here.......somewhere. It's kind of pricey too.

3. Conflicting data on the product. One study show this is good; another discredits it. That's why my partner and I decided to quit using it. Well, the horrid taste did add to it's discontinued use, to be completely honest.

Nucleomax is Uridine. Uridine is available in a very cheap medication called Núcleo C.M.P. Forte but it is only recommended for neuralgia caused by: alcoholism, toxic effects, infections, etc. and for facial paralysis.Here is a Link to Nucleo C.M.P. Forte: Available in pill form and for inyection.