smash bros and f-zero seem unlikely
Smash Bros - Kid icarus barely came out so I don't think there was enough time for them to make something for E3 unless they rush it.
F-Zero - I don't believe it will be at E3 but it'll be on the Wii U later on my guess is in the form of a downloadable title since it sounded like that was what Miyamoto was hinting at.
Starfox - Well Retro said they were working on a title that fans have been wanting for a while now. They are good at working with old franchises and Starfox has a bigger fanbase than F-Zero

“I am a brother to dragons and a companion to owls." Job:30:29
Need a second opinion before grabbing that unknown new game? Come check out my reviews at WiiWareWave, "The Friendliest Nintendo site on the 'Net."

Beyond Good and Evil 2 better be happening! In the meanwhile though, here's a fun little Let's Play of the original. Think you'll like the game if you like Zelda!LeT's PlAy BEYOND GOOD AND EVIL < Link to LP

too be fair, I've heard the movie referenced like 200+ times, and ALL I know about is Chris Tucker.

Beyond Good and Evil 2 better be happening! In the meanwhile though, here's a fun little Let's Play of the original. Think you'll like the game if you like Zelda!LeT's PlAy BEYOND GOOD AND EVIL < Link to LP