A total of 447 patients with recent major depressive episodes who had responded to SSRI monotherapy but were experiencing TESD were discontinued on their initial treatment and randomized to Brintellix 10mg daily or escitalopram 10mg daily for 8 weeks. The primary endpoint was change from Baseline to Week 8 in the Changes in Sexual Functioning Questionnaire Short-Form (CSFQ-14) total score using mixed-effects model repeated measures approach.