BRSK2 may be an autoantigen involved in the pathogenesis of small-cell lung cancer-associated limbic encephalitis.

we identified cAMP-dependent protein kinase A (PKA) as another upstream kinase of BRSK2, which can phosphorylate BRSK2 at Thr260. Kinase activity of BRSK2 can be increased through phosphorylation by PKA.

SAD-A kinase is a pancreas-specific mediator of incretin response in islet beta cells.

a novel function of BRSK2 in the regulation of GSIS in beta-cells via a PCTAIRE1 (显示 CDK16 抗体)-dependent mechanism and suggest that BRSK2 is an attractive target for developing novel diabetic drugs.

a critical role of SAD-A in the activation of PAK1 (显示 PAK1 抗体) during the onset of insulin (显示 INS 抗体) exocytosis.

The regulation of Wee1 (显示 WEE1 抗体) by SadA and SadB (显示 BRSK1 抗体) kinases is essential for the differentiation of polarized neurons.

results show that SAD-A and SAD-B (显示 BRSK1 抗体), mammalian orthologs of a kinase needed for presynaptic differentiation in Caenorhabditis elegans, are required for neuronal polarization.

Once activated, LKB1 (显示 STK11 抗体) phosphorylates and thereby activates SAD-A and SAD-B (显示 BRSK1 抗体) kinases, which are also required for neuronal polarization in the cerebral cortex.

BR serine/threonine Kinase 2 (BRSK2) 抗原简介

蛋白简介

Serine/threonine-protein kinase that plays a key role in polarization of neurons. Phosphorylates MAPT/TAU and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Ser-554'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in post-mitotic neurons, leading to down-regulate WEE1 activity in polarized neurons.