Though the surrounding area was settled much earlier, the mineral resources in the area of Anniston were not exploited until the Civil War. The Confederate States of America then operated an iron furnace near present-day downtown Anniston, until it was finally destroyed by raiding Unioncavalry in early 1865. Later, cast iron for sewer systems became the focus of Anniston's industrial output. Cast iron pipe, also called soil pipe, was popular until the advent of plastic pipe in the 1960s.[citation needed]

This panoramic map with marked points of interest illustrates a bird's-eye view of Anniston, Alabama, in 1887, fourteen years after the town was chartered in 1873. The 1880 census showed a population of 942 and, by 1890, the population was 9,998.

In 1872, the Woodstock Iron Company, organized by Samuel Noble and Union Gen. Daniel Tyler, rebuilt the furnace on a much larger scale,[6] and started a planned community named Woodstock, soon renamed "Annie's Town" for Annie Scott Tyler, Daniel's daughter and wife of railroad president Alfred L. Tyler. Anniston was chartered as a town in 1873.[7]

Though the roots of the town's economy were in iron, steel, and clay pipe, planners touted it as a health resort, and several hotels began operating. Schools also appeared, including the Noble Institute, a school for girls established in 1886,[8] and the Alabama Presbyterian College for Men, founded in 1905.[6] Careful planning and easy access to rail transportation helped make Anniston the fifth largest city in the state from the 1890s to the 1950s.

In 1917, at the start of World War I, the United States Army established a training camp at Fort McClellan. On the other side of town, the Anniston Army Depot opened during World War II as a major weapons storage and maintenance site, a role it continues to serve as munitions-incineration progresses. Most of the site of Fort McClellan was incorporated into Anniston in the late 1990s, and the Army closed the fort in 1999 following the Base Realignment and Closure round of 1995.

Anniston was the center of national controversy in 1961 when a mob bombed a bus filled with civilian Freedom Riders during the American Civil Rights Movement. As two Freedom buses were setting out to travel the south in protest of their Civil Rights following the Supreme Court case saying bus segregation was unconstitutional, one headed to Anniston, and one to Birmingham, Alabama, before finishing in New Orleans. The Freedom Riders were riding an integrated bus to protest Alabama's Jim Crowsegregation laws that denied African Americans their civil rights. One of the buses was attacked and firebombed by a mob outside Anniston on Mother's Day, Sunday, May 14, 1961. Prior to the bus being firebombed, attackers broke windows, and slashed tires, using metal pipes, clubs, chains and crowbars, before the police came to escort the bus away.[9] The bus was forced to a stop just outside of Anniston, in front of Forsyth and Sons grocery, by more mob members.[10] As more windows were broken, rocks and eventually a firebomb were thrown into the bus. As the bus burned, the mob held the doors shut, intent on burning the riders to death. An exploding fuel tank caused the mob to retreat, allowing the riders to escape the bus. The riders were viciously beaten as they tried to flee, where warning shots fired into the air by highway patrolmen prevented the riders from being lynched on the spot.[9] A 12-year-old girl, Janie Forsyth, set out against the mob with a bucket of water and cups to help the Riders, first tending to the one who had looked like her own nanny.[11] Forsyth and Son grocery is located along Alabama Highway 202 about 5 miles (8 km) west of downtown. The site today is home to a historic marker and was designated Freedom Riders National Monument by President Barack Obama in January 2017.[12][13]

In response to the violence, the city formed a bi-racial Human Relations Council (HRC) made up of prominent white business and religious leaders, but when they attempted to integrate the "whites-only" public library on Sunday afternoon, September 15, 1963 (the same day as the 16th Street Baptist Church bombing in Birmingham), further violence ensued and two black ministers, N.Q. Reynolds and Bob McClain, were severely beaten by a mob. The HRC chairman, white Presbyterian minister Rev. Phil Noble, worked with an elder of his church, Anniston City Commissioner Miller Sproull, to avoid KKK mob domination of the city. In a telephone conference with President John F. Kennedy, the President informed the HRC that after the Birmingham church bombing he had stationed additional federal troops at Fort McClellan. On September 16, 1963, with city police present, Noble and Sproull escorted black ministers into the library.[14] In February 1964, Anniston Hardware, owned by the Sproull family, was bombed, presumably in retaliation for Commissioner Sproull's integration efforts.

1888 drawing and positioning of the Noble Institute for Girls in Anniston

On the night of July 15, 1965, a white racist rally was held in Anniston, after which Willie Brewster, a black foundry worker, was shot and killed while driving home from work. A $20,000 reward was raised by Anniston civic leaders, and resulted in the apprehension, trial and conviction of the accused killer, Damon Strange, who worked for a leader of the Ku Klux Klan.[15] Historian Taylor Branch called the conviction of Damon Strange a "breakthrough verdict" on p. 391 of his Pulitzer Prize-winning book, At Canaan's Edge. Strange was convicted by an all-white Calhoun County jury to the surprise of many people, including civil rights leaders who had planned to protest an acquittal. This was the first conviction of a white person for killing a black person in civil rights era Alabama.[16]

The Anniston Western Bypass runs from Interstate 20 in Oxford (the Coldwater exit) and runs north into the present State Route 202. It is five lanes wide, handling Anniston Army Depot traffic. Future plans will extend it on the present County Road 109 by widening it to connect with US 431.State Route 202 follows this route from CR-109 (Bynum-Leatherwood Road) southward.

The Anniston Eastern Bypass was a stalled project of the Alabama Department of Transportation to build a four-lane highway in Calhoun County until revived by the 2009 federal stimulus package.[21] It was the largest influx of federal money into the local economy since Fort McClellan closed. More than $21 million was earmarked for this project in 2005. This funding was spent acquiring rights of way and grading a section of the proposed bypass from Oxford to the community of Golden Springs. As of April 2009, the section was a graded, but undriveable, clay dirt road bed. The Eastern Bypass was revived by the 2009 Federal Stimulus Package and was opened to traffic into McClellan on the northwest end in January 2011. As of December 2015, the route is now open to traffic and carries US-431 from the Saks community southward.

Amtrak serves Anniston with its daily Crescent service, operating to and from New Orleans and New York daily. Westbound trains depart at 10:00am, and eastbound trains depart at 3:59pm (central time), according to the most recent timetable (January 9, 2018).[22]

Anniston is governed by Alabama's "weak mayor" form of city government. Four city council members are elected to represent the city's four wards, and the mayor is elected at-large. Day-to-day functions of city government are carried out by the city manager, who is appointed by the mayor and city council.

Anniston is the county seat of Calhoun County, Alabama. Circuit and district courts for the county and the district attorney's office are located in the Calhoun County Courthouse at the corner of 11th Street and Gurnee Avenue. Other county administrative offices are in the Calhoun County Administrative Building at the corner of 17th and Noble streets, and a United States Courthouse, part of the U.S. Alabama Northern District Court, is located at the corner of 12th and Noble streets.

As of the census of 2010, there were 23,106 people residing in the city. The population density was 506.3 inhabitants per square mile (195.5/km2). There were 11,599 housing units at an average density of 281.5 per square mile (108.7/km2). The racial makeup of the city was 43.6% Non-Hispanic White, 51.5% Black or African American, 0.3% Native American, 0.8% Asian, 0.1% Pacific Islander, and 1.7% from two or more races. 2.7% of the population were Hispanic or Latino of any race.

There were 9,603 households out of which 20.3% had children under the age of 18 living with them, 40.0% were married couples living together, 21.0% had a female householder with no husband present, and 38.6% were non-families. 34.8% of all households were made up of individuals and 15.6% had someone living alone who was 65 years of age or older. The average household size was 2.26 and the average family size was 2.91.

In the city, the age distribution of the population shows 21.7% under the age of 18, 8.7% from 18 to 24, 25.7% from 25 to 44, 23.3% from 45 to 64, and 17.7% who were 65 years of age or older. The median age was 39 years. For every 100 females, there were 83.9 males. For every 100 females age 18 and over, there were 78.5 males.

The median income for a household in the city was $30,400, and the median income for a family was $37,067. Males had a median income of $31,429 versus $21,614 for females. The per capita income for the city was $19,689. About 25.1% of families and 29.8% of the population were below the poverty line, including 35.2% of those under age 18 and 16.2% of those age 65 or over.

In 1899, the county seat of Calhoun County moved from Jacksonville to Anniston. More than 100 years later, the community is a bustling center of industry and commerce with more than 22,000 residents. Over the years, city officials and local citizens have worked to retain the environmental beauty of the area while allowing it to thrive economically and to preserve its history. The Spirit of Anniston Main Street Program, Inc., a nonprofit organization started in 1993, spearheaded the restoration and revitalization of historic downtown Anniston, with a focus on the city's main thoroughfare, Noble Street.

The Noble Streetscape Project encouraged local business owners to refurbish storefront façades, while historic homes throughout the downtown area have been repaired and returned to their former condition. The preservation effort included the historic Calhoun County Courthouse, located on the corner of 11th Street and Gurnee Avenue since 1900. The original building burned down in 1931, but the courthouse was rebuilt a year later. Thanks to a complete restoration in 1990, the stately structure is still in use today.

WEAC-CD is the only television station that directly broadcasts from the Anniston area, but many Birmingham stations have towers and news bureaus here, such as WJSU-TV (WJSU is a local broadcast station for Birmingham-based ABC 33/40), WBRC-TV (Fox), and WVTM-TV (NBC). Alabama Public Television erected its tallest tower atop Cheaha Mountain 12 miles (19 km) south of Anniston. WJSU-TV 40 was historically a local CBS affiliate, broadcasting local newscasts daily.

Formerly its own Arbitron-defined broadcast market, today Anniston is a part of the Birmingham-Anniston-Tuscaloosa television designated market area. Radio stations are divided into three sub markets within that market; Anniston is in the Anniston-Gadsden–Talladega radio sub market.

In 2002, an investigation by 60 Minutes[27] revealed Anniston had been among the most toxic cities in the country. The primary source of local contamination was a Monsanto chemical factory, which had already been closed. The EPA description[28] of the site reads in part:

The Anniston PCB site consists of residential, commercial, and public properties located in and around Anniston, Calhoun County, Alabama, that contain or may contain hazardous substances, including polychlorinated biphenyl (PCB) impacted media. The Site is not listed on the NPL, but is considered to be a NPL-caliber site. Solutia Inc.'s Anniston plant encompasses approximately 70 acres (28 ha) of land and is located about 1 mile west of downtown Anniston, Alabama. The plant is bounded to the north by the Norfolk Southern and Erie railroads, to the east by Clydesdale Avenue, to the west by First Avenue, and to the south by Highway 202. Polychlorinated biphenyls (PCBs) were produced at the plant from 1929 until 1971.

Anniston is home to the Anniston Army Depot which is used for the maintenance of most Army tracked vehicles. The depot also housed a major chemical weapons storage facility, the Anniston Chemical Activity, and a program to destroy those weapons, the Anniston Chemical Agent Disposal Facility. In 2003, the Anniston Army Depot began the process of destroying the chemical weapons it had stored at the depot and at Fort McClellan. An incinerator was built to destroy the stockpile of Sarin, VX nerve agent, and mustard blister agent stored at the depot. Destruction of the weapons was completed in 2011.[29] The incinerator and related operations were officially closed in May 2013, and the incinerator was disassembled and removed from the depot at the end of 2013.[29]

Fort McClellan—former site of the U.S. Army Military Police Training Academy, a Vietnam era Infantry Training Center, Chemical Corps Regimental Headquarters, Chemical Warfare training center, and Women's Army Corps Headquarters—was decommissioned in the 1990s. A portion of the former fort is now home to the Alabama National Guard Training Center. Another 9,000 acres (36 km2) of the fort were set aside for the Mountain Longleaf National Wildlife Refuge in 2003. The Department of Homeland Security also uses a portion of the decommissioned fort for the Center for Domestic Preparedness, the nation's only civilian "live agent" training center; emergency response providers from all over the world come to Fort McClellan to be trained in dealing with live agents and weapons in a real-time, monitored setting.[citation needed]

Statewide testing ranks the schools in Alabama. Those in the bottom six percent are listed as "failing." As of early 2018, Anniston High School was included in this category.[30]

The school system boasts one of the most high-tech computing capabilities in the state, according to representatives from Huntsville as well as various news agencies[citation needed]. Every school is equipped with labs featuring Macintosh computers, 55-inch (1,400 mm) plasma displays, and interactive whiteboards. Some schools have more computer labs, and Anniston High School also has an ACCESS Lab that allows for videoconferencing based classes involving other schools, supported by a high speed fiber network.