Detail Information

Publications298 found, 100 shown here

Ken HonjoGraduate School of Life and Environmental Sciences, University of Tsukuba, Tsukuba 305 8572, JapanJ Neurosci 25:7905-13. 2005

..Moreover, we also show that synaptic output of larval mushroom body neurons is required for retrieval but not for acquisition and retention of the larval memory, including the CREB-dependent component...

..Results are interpreted as evidence for an automatic integration of information about action effects and taken as support of an action-concept model of action-effect integration and stimulus-response compatibility...

..We conclude that immediate access to simple stimulus-stimulus relationships is mediated via the parahippocampal gyrus, whereas the flexible representation of memory requires the recruitment of the hippocampus...

Involvement of the CA3-CA1 synapse in the acquisition of associative learning in behaving mice

..Using this framework, we consider psychological, lesion and functional imaging evidence, highlighting how informational convergence in the brain underlies the associative nature of both memory and perception...

Context, ambiguity, and unlearning: sources of relapse after behavioral extinction

..The article concludes with several issues for future research, among them the question of how we can optimize extinction and other putative "unlearning" treatments so as to prevent the various forms of relapse discussed here...

..Consistent with proposed roles in reward prediction and incentive salience, these results indicate that rapid dopamine release provides a reward signal that is dynamically modified by associative learning...

Prediction error during retrospective revaluation of causal associations in humans: fMRI evidence in favor of an associative model of learning

..Contrary to prior assumptions, the hippocampus and caudate interact cooperatively to facilitate successful TI. We suggest that the dynamics of the relationship between the hippocampus and caudate depends critically upon task demands...

Dentate gyrus is necessary for disambiguating similar object-place representations

Sanne de WitDepartment of Psychology, Amsterdam Center for Study of Adaptive Control in Brain and Behavior Acacia, University of Amsterdam, Roeterstraat 15, 1018 WB, The NetherlandsJ Cogn Neurosci 23:1218-29. 2011

..If anything our results suggest a disease severity-dependent deficit in goal-directed behavior. These results are discussed in the context of Parkinson disease and the neurobiology of habitual and goal-directed behavior...

..quot; We also found that acute stress impaired the animal's performance in the episodic-like memory task, which, however, could be partially reversed by the N-Methyl-D-aspartate-receptors agonist D-cycloserine...

..This emergent shape selectivity reflects activation of neurons representing the motion stimuli recalled by association, and it suggests that recall-related activity may be a general feature of neurons in visual cortex...

..Critically, together with a separately conducted behavioral study, these data raise the possibility that PrC encoding operations -- in conjunction with hippocampal mechanisms -- contribute to later recollection of presented item details...

An investigation of learning strategy supporting transitive inference performance in humans compared to other species

..Taken together, these data suggest that the caudal AC is involved early in trace eyeblink conditioning and that maintenance of the CS-elicited excitatory response may serve to signal the salience of the tone...

..These data provide clear evidence for reinstatement and for the role of negative stimulus valence in the return of conditioned responding after extinction...

NMDA receptor-dependent processes in the medial prefrontal cortex are important for acquisition and the early stage of consolidation during trace, but not delay eyeblink conditioning

Kaori Takehara-NishiuchiLaboratory of Neurobiophysics, School of Pharmaceutical Sciences, The University of Tokyo, JapanLearn Mem 12:606-14. 2005

..These results suggest that the mPFC participates in both acquisition of a CR and the early stage of consolidation of memory in trace, but not delay eyeblink conditioning by NMDA receptor-mediated operations...

..These findings demonstrate the paradoxical situation in which learning can be improved under sequential-task conditions and have important implications for training, decision making, and understanding interactive memory systems...

Impaired associative learning in chronic schizophrenics and their first-degree relatives: a study of latent inhibition and the Kamin blocking effect

..These results suggested that while the ipsilateral cerebellum is essential for the expression of trace CRs, its contribution to the acquisition of trace CRs appears to mainly depend on the time length of TI...

Foxp2 mutations impair auditory-motor association learning

Simone KurtInstitute of Neurobiology, University of Ulm, Ulm, GermanyPLoS ONE 7:e33130. 2012

..of proficient spoken language involves auditory-guided vocal learning, a specialized form of sensory-motor association learning. The impact of etiological Foxp2 mutations on learning of auditory-motor associations in mammals has not ..

..tasks requiring flexible adaptation to external feedback, which could be related to impairments in reward association learning. To study the effect of aging on stimulus-reward association learning 20 young and 20 older adults ..

..The experiments revealed significant individual differences, suggesting that use of multiple categories is one of a number of strategies that can be used rather than being the basis for most category-based induction...

..In the right visual field/left hemisphere, both N400 and Late Positive Component (LPC/P600) were modulated by semantic relatedness, while only a late effect was present in the left visual field/ right hemisphere...

..These findings suggest that higher order cognitive abilities begin emerging early in development. Across ontogeny, however, there are changes in the limits and parameters that support associative learning...

Dopamine and octopamine differentiate between aversive and appetitive olfactory memories in Drosophila

..Our results suggest that in associative conditioning, different memories are formed of the same odor under different circumstances, and that they are linked to the respective motivational systems by their specific modulatory pathways...

Research Grants69

..These studies would importantly influence our thinking about elementary associative learning processes. They would illuminate the process of extinction, a process important both to clinical applications and to neural investigations. ..

..Project 4 extends the studies in Project I - 3 to an explicit decision criterion task where observers adjust an observable decision criterion on each trial. These data are useful for testing learning models. ..

..intermittent delivery). Elucidating the behavioral processes underlying acquisition and expression of Pavlovian drug conditioning will have important implications for prevention and intervention strategies. ..

..Emotional experiences will come to be viewed as fluid, emergent phenomena that are constructed and elaborated via mental representations. In the broadest context, it has the potential to impact research where emotion plays some role. ..

..This hypothesis will be tested by measuring damage to specific subregions of the MTLC in MCI patients, and assessing relationships between such damage and familiarity-based memory performance. [unreadable] [unreadable] [unreadable]..

..The participation of minorities and women has been emphasized at each level (organizers, speakers, students). Thus the conference will address important scientific, social, and educational issues. [unreadable] [unreadable] [unreadable]..

..Understanding the underlying neurobiology will not only further aid in this understanding but will also aid in developing treatments for alcoholism and nicotine addiction. [unreadable] [unreadable]..

..The potential for amelioration of these cognitive deficits using both behavioral and pharmacological strategies will provide important information regarding treatment approaches for afflicted individuals. ..

..The present study will investigate how awareness interacts with startle in PTSD subjects. Finally, the present study will examine the relationship between contingency awareness and fear inhibition. ..

..These experiments should help establish the translational validity of the extinction model for anxiety disorder treatment and also may yield potential improvements in current anxiety disorder treatments. ..

..Subsequent research will adapt this experimental approach to evaluate other core assumptions of the theory. Findings from this programmatic research will have important theoretical and applied implications. ..