Ether Lipid Metabolism

Saccharomyces cerevisiae

Metabolic Pathway

The metabolism of ether lipids can begin with 1-O-Hexadecyl-2-O-acetyl-sn-glycerol and citicoline reacting through a CPT1 resulting in the release of CMP, 2-acetyl-1-alkyl-sn-glycerol-3-phosphocholine (PAF), in this case, a 2-acetyl-1-hexadecyl-sn-glycero-3-phosphocholine. The latter compound reacts with a cytidine monophosphate through a platelet-activating factor acetylhydrolase IB subunit alpha resulting in the release of acetic acid, hydrogen ion and lysoPAF. The latter compound can react with a palmitic acid reacting with TAG lipase / steryl ester hydrolase / phospholipase A2 / LPA acyltransferase resulting in the release of water and 1-O-Palmityl-2-palmitoyl-rac-glycero-3-phosphocholine. The latter compound can also be generated by 1-O-Hexadecyl-2-palmitoyl-sn-glycerol reacting with citicoline through a diacylglycerol cholinephosphotransferase resulting in the release of 1-O-Palmityl-2-palmitoyl-rac-glycero-3-phosphocholine and Cytidine monophosphate. 1-O-Hexadecyl-2-palmitoyl-sn-glycerol reacts with CDP-Ethanolamine through a bifunctional diacylglycerol cholinephosphotransferase/ethanolaminephosphotransferase resulting in the release of 1-hexadecyl-2-palmitoyl-glycero-3-phosphoethanolamine and Cytidine monophosphate

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