Here is a statement from Dr. John Crisler (SWALE) about taking too much HGC.

HCG should never be administered at more than 500iu at a time. That is because there are only just so many Luteinizing Hormone (LH)--the natural hormone it mimics--receptors (where LH and HCG binds on the cells in the body, and subsequently causes an effect) in the body. And once you go above around (dosages vary greatly across the population) 500iu, you don’t get more testosterone, but you do make more estrogen and progesterone. Both are highly feminizing hormones in men.

Also, the body recognizes all that HCG, and subsequently downregulates the receptors for LH. That is the “desentization” you hear about all the time on the bodybuilding and men’s health forums.

My strategy in “Backfilling the Pathways” is to create as normal a hormonal environment as possible within the body. So, for HCG, for instance, that means mimicking natural LH concentrations. That means only 100-150iu of HCG per day. And if you think about it: if normal concentrations of LH (or its mimic, HCG) “desensitized” us, we would all be “desensitized”.