A BBSRC-funded post-doctoral position is available to study neuronal splicing mechanisms in a Drosophila model. Our work aims at understanding the molecular determinants of gene-specific regulation of alternative splicing. We will biochemically characterize in vitro protein-protein and RNA-protein interactions based on available X-ray structures and determine their contribution to alternative splicing regulation in neurons of transgenic Drosophila. These studies will help to elucidate general mechanisms of alternative splicing regulation and contribute to the deciphering of the splicing code.

The post is part of a collaboration between the laboratories of Matthias Soller and Klaus Fütterer to characterise the function of RNA binding proteins aided by structural information. We seek to recruit a technically skilled and scientifically creative postdoctoral researcher to drive forward an ambitious research programme, embedded in an exciting, multi-disciplinary research environment.

The successful applicant will be self-motivated and hold a PhD in molecular biology and/or biochemistry. Extensive experience in protein purification and structure-function analysis is a must, with experience in Drosophila genetics or the study of RNA-protein interactions an advantage.