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May 25, 2012 | Conducting human missions beyond low-Earth orbit to destinations such as asteroids and Mars will require substantial work to ensure the well-being of the crew. These new operational conditions, which will include long periods in microgravity, will pose health risks that are currently not well understood and perhaps unanticipated. Developing and applying advanced tools to predict, assess, and mitigate potential hazards to astronaut health is critical.