The following work has been completed as part of the Birmingham University Clinical Psychology doctorate. Volume I contains a literature review and research paper. The literature review summarises research exploring intimate partner or wider social support on medication adherence for people living with HIV. The research paper describes a qualitative study into the body image and sexual intimacy experiences of women who have undergone a mastectomy with reconstruction and their partners. Volume II of the thesis contains four clinical practice reports (CPRs) and the abstract of a fifth which was presented orally. CPR1 is the case of a 6-year old boy presenting with encopresis formulated from a behavioural and psychodynamic perspective. CPR2 is a case study of 12-year old boy presenting with separation anxiety. CPR3 documents a single-case experimental design that assessed the effectiveness of a Cognitive Behavioural Therapy intervention with a 75-year old woman with panic attacks. CPR4 is a small-scale service evaluation assessing psychological need and barriers to service engagement for people living with HIV. An abstract outlining CPR5, a clinical presentation about an assessment for a 12-year old boy attending a community learning disability team who was displaying anxiety and anger, is also included.