2019-09-15T15:36:01+04:30http://journal.qums.ac.ir/browse.php?mag_id=36&slc_lang=fa&sid=136-5002019-09-1510.1002The Journal of Qazvin University of Medical SciencesJ Qazvin Univ Med Sci1561-36662423-581410.29252/qums200151Protective effect of fish oil against Indomethacin induced gastric ulcer in ratsM.ASajadiMKhksariSHHassaniMShariati
Background: Nonsteroidal anti-inflammatory drugs such as indomethacin cause gastrointestinal damage in animals and humans. Objective: To investigate the protective effect of intragastric fish oil on indomethacin induced gastric ulcer in rats. Methods: The adult male rats were divided into 4 groups in which groups I and II were fed normally and groups III and IV were treated with daily 1.6 ml fish oil and sunflower oil for 4 weeks respectively. Gastric ulcer was induced in group II by injection of NaHCO3 and in the other three groups by indomethacin S.C at 20 mg/kg. The lesions in the stomach were measured by a dissecting microscope. The ulcer index, volume, acidity of gastric contents and acid output were also measured. The weight of animals were determined in all groups. Findings: The results indicated that an ulcer index in group III was 54.3% and 58.7% lower than groups I and IV respectively however, no significant difference in ulcer index were seen between groups I and IV. Acid volume and acid concentration in fish oil groups were 70% and 50% lower than group IV. Acid output was also 85.7% and 83.7% lower in groups I and IV respectively. The difference in weight increase between groups I and III were not significant. Conclusion: It is suggested that, fish oil protects the gastric mucosa from indomethacin induced lesions, but sunflower oil dose not have such effect. The inhibitory action of fish oil appears to be mostly related to its antisecretory activity.
Fish oilPeptic ulcerIndomethacinSunflower oil2001501310http://journal.qums.ac.ir/article-1-500-en.pdf36-5012019-09-1510.1002The Journal of Qazvin University of Medical SciencesJ Qazvin Univ Med Sci1561-36662423-581410.29252/qums200151Mixture of Lidocaine and Bupivacaine in spinal anesthesiaMEbtehajHKayyalha
Background: Spinal anesthesia with lidocaine has a shorter duration as compared to bupivacaine. Objective: To evaluate the effect of the mixture of lidocaine and bupivacaine in spinal anesthesia. Methods: This semi experimental study was performed on 40 patients (20 men and 20 women) who had to undergo surgery on lowerlimb, pelvis and lower abdomen. No contraindication for spinal anesthesia was observed in these patients. Findings: The findings indicated that the duration of action was less than 75 minutes in 4 (10%) patients, in range of 75 to 89 min in 12 (30%) cases, 96 to 104 min in 12 (30%) cases and more than 105 min in 12 (30%). Conclusion: Mixture of lidocaine with bupivacaine results in a medium duration of action in spinal anesthesia.
Spinal anesthesiaLidocaineBupivacaineDuration of action20015011114http://journal.qums.ac.ir/article-1-501-en.pdf36-5022019-09-1510.1002The Journal of Qazvin University of Medical SciencesJ Qazvin Univ Med Sci1561-36662423-581410.29252/qums200151The effect of Halothane and Ketamine on SaO2: Anesthesia of patients with cyanotic heart diseaseS.AHosseini JahromiMS.M Hosseini Valami
Background: Maintenance of SaO2 in normal range is an essential problem in anesthesia of patients with cyanotic heart disease. Objective: To compare the effects of halothane and ketamine as inductive agents on SaO2 in anesthesia of patients with cyanotic heart disease. Methods: 50 patients who referred to Shahid Faghihi hospital of Shiraz in 1995 were divided into two equal groups. One group was anesthetized with Ketamine and the other with halothane. In the first ten minutes, SaO2 was measured every minute. The gathered information were evaluated by repeated measure-analysis of variance and T-test. Findings: There was no significant statistic difference between two groups, regarding SaO2. Conclusion: Halothane has priority to Ketamine since intramascular injection of Ketamine in children leads to pain and crying, thus increases the incidence of Tet spell and decreases SaO2.
Cyanotic heart diseaseInduction of anesthesiaHalothaneKetamine20015011519http://journal.qums.ac.ir/article-1-502-en.pdf36-5032019-09-1510.1002The Journal of Qazvin University of Medical SciencesJ Qazvin Univ Med Sci1561-36662423-581410.29252/qums200151Progress of labor with epidural anesthesia in normal deliveriesFAmidiMKhanalihaARezaei
Background: Findings a simple, lowcost and safe method for delivery is of great importance. Objective: To determine the duration of active phase and the second stage of vaginal delivery with epidural anesthesia. Methods: In a randomized clinical trial 36 patients were studied. 18 patients underwent epidural anesthesia as case group and 18 others with no anesthesia as control group. The duration of the active phase and the second stage of both methods and apgar score for both groups were compared. Findings: The duration of the active phase was less in the epidural anesthesia group (155.45±37.3 vs 169±48.14 min) where as the duration of the second stage was longer (78.18±22.29 vs 58.64±17.57 min). The apgar score second and C/S rates were the same in both groups. Conclusion: Vaginal delivery with epidural anesthesia is painless and safe.
Epidural anesthesiaActive phaseSecond stageVaginal delivery20015012024http://journal.qums.ac.ir/article-1-503-en.pdf36-5042019-09-1510.1002The Journal of Qazvin University of Medical SciencesJ Qazvin Univ Med Sci1561-36662423-581410.29252/qums200151Cerebrospinal fluid osmolality and carotid blood flow in normal and brain edema conditionsM.RJafariARostamiMNemat Bakhsh
Background: Vasogenic brain edema disturbs blood brain barrier and consequently increase intracranial pressure. It may also affect CSF electrolytes concentrations and brain blood flow. Objective: To compare the CSF osmolality and carotid blood flow in normal and brain edema conditions in rabbits. Methods: 6 groups of rabbits were studied in which 3 groups had normal carotid blood flow and in the other 3, the vasogenic brain edema was obtained by ligation of common carotid arteries. The osmolality of CSF and carotid blood flow were determined and compared with normal determination. Pathological and radiological investigations were also determined. Findings: Brain edema was confirmed with CT Scan and pathological findings. The osmolality of CSF in brain edema and normal conditions were 290.9±7.6 and 296±5.73 mosmole/kg and carotid brain flow were 6.77±0.24 and 7.83±1.09 ml/min respectively. No significant difference between normal and edema conditions were observed. Conclusion: The reduction of brain blood flow in brain edema may compensate with increase of systemic blood pressure. The CSF osmolality did not change during brain edema.
Brain edemaCerebrospinal fluid (CSF)Carotid blood flowRabbit20015012528http://journal.qums.ac.ir/article-1-504-en.pdf36-5062019-09-1510.1002The Journal of Qazvin University of Medical SciencesJ Qazvin Univ Med Sci1561-36662423-581410.29252/qums200151Changes in the respiratory function of medical students caused by Formaldehyde exposureMJavdanTEntezari zaher
Background: In recent decades, scientists have paid more attention to the relation between formaldehyde vapour and respiratory function of people exposed to this material. Objective: To evaluated the effect of formaldehyde vapour in gross anatomy dissection laboratory on respiratory function of medical students. Methods: Two groups of medical students were understudy. The first group consisted of 23 boys and 28 girls which were in the third term and had chosen the course of trunk practical anatomy. The second group consisted of 13 boys and 25 girls which were in the first term and did not have practical anatomy nor worked in dissection laboratory. The experiment and the control group performed spirometry with a gap of 2 hours, once before and once after the class. Findings: Decrease of FVC, FEV1 and FEV1/FVC were observed in the experiment group. Decrease of FVC and FEV1 were significant in boys while decrease of FEV1/FVC was not significant. Decrease of all above cases were significant in girls. The items did not decrease in the control group. Conclusion: The findings revealed that formaldehyde vapour in dissection laboratory decreases the respiratory function of medical students. The sensitivity of girl students to this vapour was much more as compared with boy students.
Respiratory functionSpirometryFormaldehyde20015012934http://journal.qums.ac.ir/article-1-506-en.pdf36-5072019-09-1510.1002The Journal of Qazvin University of Medical SciencesJ Qazvin Univ Med Sci1561-36662423-581410.29252/qums200151Post herniorrhaphy urinary retention in local or general anesthesiaPFallahUShafighNJediSAsefzadehH.RSalamat
Background: Inguinal hernia is a common disorder which should be operated as soon as diagnosed. It is operated under general, spinal or local anesthesia. Objective: To determine and compare the rate of urinary retention in patients operated under general or local anesthesia. Methods: 50 patients over 40 years old were prospectively reviewed in Shahid Rajaee hospital in Qazvin during 1999. They were divided into two groups in which group I (24 patients) underwent operation under local anesthesia and group II (26) under general anesthesia. All patients had a type II Nyhus classification. Findings: 3 cases out of group I developed urinary retention (12.5%) while 10 cases out of group II developed the same complication (38%). The difference was statically significant. Conclusion: The findings indicated a significantly higher incidence of urinary complication in patients operated under general anesthesia.
SurgeryLocal anesthesiaInguinal hernia20015013537http://journal.qums.ac.ir/article-1-507-en.pdf36-5082019-09-1510.1002The Journal of Qazvin University of Medical SciencesJ Qazvin Univ Med Sci1561-36662423-581410.29252/qums200151Sonographic accuracy in diffuse renal parenchymal diseasesSZojajiShMoradinejad
Background: Sonography is a safe and simple method for diagnosis of diffuse renal parenchymal disease. Objective: To detect the accuracy and value of sonography in presence of diffuse renal parenchymal disease. Methods: Through a double blind study, ultrasound examination was carried out in 100 patients of nephrology wards of Shiraz hospitals during 1998 to 1999. According to sonographic findings, the patients were assessed for renal size, cortical echogenicity and appearance of renal pyraminds. Transcutaneus kidney biopsy was performed within 24 hours and according to pathological findings, the patents were divided into eleven different groups. Renal specimen were examined without any sonographic information. Findings: The findings revealed statistically meaningful correlation between renal cortical echogenicity and prominency of pyramids and glomerulosclerosis, crescent formation tubular atrophy and interstitial fibrosis or inflammation but no correlation with hypercellularity renal sonography for detection of diffuse renal parenchymal disease had 86% sensitivity, 57% specificity and 82% accuracy. Conclusion: Sonography is a useful diagnostic method for diagnosis of renal parenchymal disease however, it cannot be relied on regarding the type of microscopic changes or specific histological diagnosis.
: Diffuse renal parenchymal diseasesUltra sonographyDiffuse renal diseaseInterstitial nephritisKidneyHistopathology20015013842http://journal.qums.ac.ir/article-1-508-en.pdf36-5092019-09-1510.1002The Journal of Qazvin University of Medical SciencesJ Qazvin Univ Med Sci1561-36662423-581410.29252/qums200151Sympathetic skin response in BrucellosisBKazemiM.RAlavian GhavaniniMJazayeriMJonobi
Background: Many patients with brucellosis complain of symptoms such as tingling and numbness. Objective: To evaluate the sympathetic skin response of patients with brucellosis. Methods: S.S.R test was performed on 30 patients with brucellosis who did not have any other systemic disease as case group and 30 healthy subjects as control group. Findings: The findings indicated significant difference in lower and upper parts of the body between two groups (P<0.05). 46.6% of the patients had abnormal S.S.R. Conclusion: Sympathetic system involvement (Mostly efferent C fibers) is highly suggested in brucellosis.
: BrucellosisNeuropathySympathetic skin response (SSR)20015014349http://journal.qums.ac.ir/article-1-509-en.pdf36-5102019-09-1510.1002The Journal of Qazvin University of Medical SciencesJ Qazvin Univ Med Sci1561-36662423-581410.29252/qums200151Evaluation of blunt abdominal traumaS.AHajseidjavadi
Background: Symptoms of blunt abdominal trauma and the related diagnostic methods are of great importance. Objective: To evaluate blunt abdominal trauma in Shahid Rajaee hospital of Qazvin. Methods: Through a retrospective study, 313 patients with blunt abdominal trauma out of 1017 traumatic cases, who referred to Shahid Rajaee hospital from 1993 to 1996, were selected. Findings: The findings indicated that the most common involved organs were spleen, liver, small bower, kidney and ureters respectively. The most common signs in alert patients were pain, drop of blood pressure and sign of peritonitis. More admissions happened in summer specially in the month of Shahrivar, and more in males than females with the rate of 4 to 1. There were 87.9% discharged cases and 9.9% mortality cases. 47% of the cases had splenic trauma, 25.5% liver trauma and 14.3% small bowel trauma. Conclusion: Different results specially in U.S.A is probably due to fastening the seat belts while driving which results in more bowel trauma and less liver trauma.
Blunt abdominal traumaSpleenLiver20015015054http://journal.qums.ac.ir/article-1-510-en.pdf36-5112019-09-1510.1002The Journal of Qazvin University of Medical SciencesJ Qazvin Univ Med Sci1561-36662423-581410.29252/qums200151Introducing a new method to detect bound C3d on erythrocytes during complement activationAAfshariEHolme
Background: Measurement of complement activation products has recently been the popular means of assessing the complement activation. Objective: To introduce a new method to detect bound C3d on erythrocytes during complement activation and to compare it with free C3d levels. Methods: An indirect ELISA used in routine measurement of free C3d levels was developed together with the modified ELISA. To capture bound C3d on erythrocytes, ELISA plate were coated with anti-C3d and after incubation, blood samples were added for two hours. Bound erythrocytes were lysed with 100µl water perwell and the OD were read at 405nm. Findings: The levels of free C3d and bound C3d on the erythrocytes during complement activation was significantly increased compared to the control (800% and 500% respectively). Conclusion: Both free C3d and bound C3d as final dogradation product of C3d reflect the ongoing complement activation.
C3dComplement activationErythrocyte20015015560http://journal.qums.ac.ir/article-1-511-en.pdf36-5122019-09-1510.1002The Journal of Qazvin University of Medical SciencesJ Qazvin Univ Med Sci1561-36662423-581410.29252/qums200151The fertility and viability study of human Hydatid cystMFasihi HarandiIMobedi
Background: Cystic hydatid disease is one of the most important parasitic diseases in Iran. Studies on fertility of the cysts and viability rate of protoscoleces will provide useful data for surgeons and researchers. Objective: To determine fertility rates of cycts and viability of protoscoleces in human cases of hydatid disease. Methods: Samples of human hydatid cysts were collected during surgery and transferred in normal saline to the research lab. After collecting and washing protoscoleces, their viability rate was measured using eosin exclusive test. Findings: Of 73 cases, 57.5% were women and 42.5% men. 60.4% were in the age range of 20 to 49. The location of cysts were predominantly in liver (64.4%), lung (16.4%) or both (9.6%). A large proportion of cysts were fertile (84.9%). The viability rate of protoscoleces in fertile cysts were found to be 46.4%. Conclusion: Results of the present study have great implications for medical and surgical management of the disease.
Echinococcus granulosusHydatid cystHumanProtoscolexesViability20015016167http://journal.qums.ac.ir/article-1-512-en.pdf36-5132019-09-1510.1002The Journal of Qazvin University of Medical SciencesJ Qazvin Univ Med Sci1561-36662423-581410.29252/qums200151Sensitivity of Penicillin in group A Beta-hemolytic StreptococusAKamalyMDaneshyM.RKheirkah
Background: Penicillin is a choice drug for treatment of streptococcal pharyngitis and is not toxic nor expensive. It is effective in all groups of streptococcus. Objective: To determine penicillin sensitivity in GABHS. Methods: 44 isolates of GABHS from 500 patients who referred to Qods hospital of Qazvin with symptoms of pharyngitis were collected to determine the frequency of antimicrobial resistance. Susceptibility testing was performed according to the guidelines of laboratory standards by the tube microdilution for penicillin. Antibiogram was performed by disk method for penicillin and 5 other antibiotics. Findings: Minimum bacterial concentration for GABHS was 0.0025 to 0.02. 100% of strains were sensitive to penicillin, amoxicilin and erythromycin but resistant to co-trimoxazole. Conclusion: Penicillin is the most effective and reliable drug for GABHS. Amoxicilin and erythromycin are recommended as choice drugs for cases of allergy.
PenicillinSensitivityGABHS (Group A beta hemolytic streptococus)20015016872http://journal.qums.ac.ir/article-1-513-en.pdf36-5142019-09-1510.1002The Journal of Qazvin University of Medical SciencesJ Qazvin Univ Med Sci1561-36662423-581410.29252/qums200151Febrile convulsionMSarreshtedari
Febrile convulsion is one of the most common neurologic disorder in childhood which is an age related phenomenon. There are many conflicts about characteristics of this type of seizure, treatment of acute type of the disease and preventive measures. For preparing this review article, the available references of the last ten years (1991-2000) have been studied. According to the results of this review, longterm treatment with anticonvulsant drugs such as phenobarbitals not recommended due to the consequent lowering of the IQ and reduction of cognitive ability. Preferable preventive treatment is intermittent diazepam during a febrile disease.
FebrileConvulsionIntelligence quoitest (IQ)20015017380http://journal.qums.ac.ir/article-1-514-en.pdf36-5152019-09-1510.1002The Journal of Qazvin University of Medical SciencesJ Qazvin Univ Med Sci1561-36662423-581410.29252/qums200151A case of anaplastic large cell lymphoma (B cell type)FHajmanochehri
Malignant large cell lymphoma is a rare and new entity and its position in some classifications for example REAL classification is in the group of peripheral T-Cell/natural killer cells. This classification somehow must be modified since some of the lymphoma show B cell marker rather than T-cell marker. This report presents a case of anaplastic large cell lymphoma (B cell type) in which a 70 year old man had cervical lymphadenopathy. Histological and immunohistochemical findings were evaluated.
Anaplastic large cell lymphomaLymphadenopathyCD3020015018185http://journal.qums.ac.ir/article-1-515-en.pdf