Establishment of normative values for morphometric analysis methods in age-stratified normal controls, and comparison of the sensitivity and specificity of these measure to pre- and postsurgical localization of the epileptogenic zone in patients...

Determination of the sensitivity and specificity of source localization using MEG/EEG an resting fMRI/EEG compared to surgical localization of epileptic foci.

Evaluate changes in activation during rest, as well as language and memory fMRI tasks in patients pre- and postsurgically, to examine the effets of epileptogenic zones and surgery on cognitive function and the networks underlying these functions...

250

All

8 Years to 65 Years (Child, Adult)

NCT02107989

14006114-N-0061

April 5, 2014

July 29, 2020

July 29, 2020

April 9, 2014

February 8, 2018

National Institutes of Health Clinical Center, 9000 Rockville PikeBethesda, Maryland, United States

The primary endpoint was the number of patients in a population of subjects older than 60 years with new-onset epilepsy but without cognitive impairment whose profile of the CSF biomarkers of the AD is suggestive of an AD.