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Presentation on theme: "To view the notes associated with this PowerPoint presentation, click the Edit button along the top tool bar or right-click with the mouse and select the."— Presentation transcript:

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To view the notes associated with this PowerPoint presentation, click the Edit button along the top tool bar or right-click with the mouse and select the Edit Slides option.

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Review of Laboratory Systems

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The Laboratory Response Network

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Michigan Laboratory System

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Regional Laboratories in MI

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Regional laboratories Level B (confirmatory) lab for each region Each laboratory supports a specific city, county or group of counties Receive clinical specimens from Level A (sentinel) laboratories Rule In and Refer to MDCH Level B-C lab in Lansing

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Biosafety Levels BSL-2, designed for working with agents of moderate risk Work may be done on benchtop Aerosol producing procedures done in a biosafety cabinet Personal protective equipment (PPE) Immunizations Training required Access restricted

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Biosafety Levels BSL-3, designed for working with infectious agents which may cause serious or lethal disease as a result of exposure via inhalation All BSL-2 requirements plus ~Secondary barrier ~Inward directional, one pass airflow ~Sealed walls, ceiling ~Extra PPE may be required

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Biosafety Level 3 Safety Equipment (Primary Barriers) 2.5

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Biosafety Levels BSL-4, for work with dangerous and exotic agents that pose high-risk of inhalation transmitted laboratory acquired infections and life threatening disease Two types of BSL-4 Cabinet lab Suit lab

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Role of Confirmatory Laboratories (Levels B-C) in a Bioterrorist Event Aid in rapid detection of cases Play a role in detection of covert attacks Identify and characterize isolates referred by the sentinel laboratories Collaborate with law enforcement Preserve original specimens and cultures pursuant to a criminal investigation Convey information appropriate law enforcement agency and FBI

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Level 1 CTLN Laboratories Level 1 laboratories do not perform laboratory testing for chemical agents. Chemical Terrorism Laboratory Coordinators (CTLC) will provide technical assistance and training in the collection, handling and shipment of human specimens in response to a chemical terrorism incident to the Level 1 labs. Samples from a CT event are evidence. Training for level 1 labs is top priority for MDCH.

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Laboratory Response Team Facilitate acquiring blood, serum and urine specimens as rapidly as possible Assist specimen shipment from emergency room, hospital or on-site facility The first 40 specimens will be sent to the CDC lab If help is needed, fly CDC staff to site of CT incident

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MDCH Laboratories Will Provide laboratory training & consultation for level 1 labs Provide laboratory surge capacity to the CDC laboratories in the event of a CT incident Assist in the analysis of human specimens from anywhere in the US Must be ready to perform specimen analysis within 3 hours of notification by the CDC

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Federal Regulations The Antiterrorism and Effective Death Penalty Act of 1996 Result of inappropriate purchase of plague No prior mechanism to take legal action Regulated the transfer of selected agents Required HHS to issue rules to implement these regulations Proposed list of select agents

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Federal Regulations Select Agent Rule 42 CFR 72.6 Effective April 15, 1997 Designated the CDC as the enforcing agency Established requirements for all facilities transferring or receiving select agents. Required reporting of all transfers of the select agents Tracked the acquisition and transfer of agents Established an emergency notification process Included list of select agents.