glycolytic myopathy any metabolic myopathy resulting from a defect of glycolytic enzyme activity, marked by exercise intolerance and cramping, the accumulation of glycogen in muscle, and recurrent myoglobinuria.

late distal hereditary myopathydistal myopathy that sets in usually after age 40, does not affect life span and first affects the small muscles of the hands and feet and then spreads proximally.

metabolic myopathy myopathy due to disordered metabolism, usually caused by genetic defects or hormonal dysfunction.

chron·ic pro·gress·ive ex·ter·nal oph·thal·mo·ple·gi·a (CPEO),

ocular myopathy

slowly progressive weakness of ocular muscles, characterized by decreased mobility of the eye and drooping of the upper lid. The disorder may be unilateral or bilateral and may be caused by damage to the oculomotor nerve, an intracranial tumor, or a neuromuscular disease.

ophthalmoplegia

Paralysis of the ocular muscles. External ophthalmoplegia refers to paralysis of one or more extraocular muscles. If the levator palpebrae muscle is also involved, the condition is usually referred to as ocular myopathy. Internal ophthalmoplegia refers to a paralysis of the muscles of the iris and the ciliary muscle. Total ophthalmoplegia refers to a paralysis of all the muscles in the eye, which results in ptosis, immobility of the eye and pupil, and loss of accommodation. SeeGraves' disease; paralysis of the third nerve.chronic progressive external ophthalmoplegia(CPEO) A rare disorder characterized by a progressive, bilateral ptosis and a loss of ocular motility. It is associated with mutation of mitochondrial DNA, which results in abnormalities in highly oxidative tissues such as the muscles and the brain. The initial sign is bilateral ptosis, followed later by strabismus. A related mitochondrial myopathy is the Kearns-Sayre syndrome in which there is CPEO, a type of retinitis pigmentosa characterized by coarse pigment clumping which principally affects the central retina, and cardiac conduction defects. This syndrome presents before age 20 years. Seemyasthenia gravis.internuclear ophthalmoplegia(INO) An eye movement disorder resulting from a lesion in the medial longitudinal fasciculus, which disrupts the coordination between the oculomotor nucleus and the abducens nucleus. It is characterized by a limited adduction by the eye on the same side of the body as the lesion, and a jerky, horizontal nystagmus and overshoot by the other eye on abduction, when moving the eyes towards the side of the body opposite to that of the lesion. Convergence is usually intact, unless the lesion is widespread. Vertical gaze gives rise to nystagmus and oscillopsia. The condition is associated with multiple sclerosis, vascular disease, tumour of the brainstem or encephalitis. Seeocular dysmetria; supranuclear gaze palsy; 'one and one half' syndrome.

All content on this website, including dictionary, thesaurus, literature, geography, and other reference data is for informational purposes only. This information should not be considered complete, up to date, and is not intended to be used in place of a visit, consultation, or advice of a legal, medical, or any other professional.