Kakkonto extract is well known herbal medicine often used as a cold remedy. When using kakkonto, please do not consume the following:

That is kakkonto with tuna sashimi.

Kakkonto has the effect of trapping histamine within your body, which often is the cause for allergic symptoms. On the other hand, tuna contains histidine, which converts to histamine once inside a human body. Accordingly, when kakkonto and tuna are consumed at the same time, histamine increases to a dangerous level potentially causing perspiration, vomiting, headaches, etc.

Also, in addition to tuna, yellowtail, saury, chicken also contain lot of histamine. Please be careful.