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Vitamin D is necessary for utilization of
calcium and phosphorus and in many ways acts as a hormone.1,2,3 The two
most important forms of vitamin D are cholecalciferol (D3), which is
derived from our own cholesterol and ergocalciferol (D2), a plant
analogue derived from the diet. The cholecalciferol supplied by
Life Extension is synthetic, but its form is identical to that which is
derived from cholesterol and synthesized by sunlight on the skin.
Cholecalciferol Vitamin D is essential for bone growth and maintenance
of bone density along with calcium and magnesium.4,5,6,7

A dietary deficiency of vitamin D
inhibits the production of the protein that binds calcium in the
intestines. As a result, calcium cannot be absorbed, even if there
is adequate intake which is why most
mineral
supplement formulas also contain vitamin D-3. Deficiencies of
vitamin D are often found in the elderly and in women who have low
intake of milk and receive inadequate exposure to sunlight.
Vitamin D is potent in minute quantities; one microgram of
cholecalciferol has 40 IU of vitamin D activity.3,8,9

Vitamin D plays several roles in bone. One of
them is provoking the osteocalcin gene into action. Once synthesized, however,
osteocalcin needs vitamin K to function properly.

Vitamin D
has dominated discussion on bone because it is a hormone that acts swiftly and
dramatically. But the slower-acting vitamin K is just as important. And,
although it doesn't act as quickly on bone as vitamin D, new research
indicates that vitamin K may actually be more of a hormone than currently
appreciated.

The truth is that although vitamin D has gotten
a lot of press as the bone vitamin, bone maintenance requires many factors;
among them, parathyroid hormone, estrogen, calcium and calcitonin (another
thyroid hormone). When all of these factors plus vitamin K are present in
adequate amounts, the skeleton will be totally replaced every 8 to 10 years
with good, dense bone. If not, problems can occur.

Caution: Large doses
(1400-2000 IU/day) may cause hypercalcemia, a decrease in renal function, and
nephrocalcinosis. Monthly blood tests to monitor serum calcium and parathyroid
hormone levels should be done to protect against these health issues.
Those with underlying kidney disease should avoid high doses of vitamin
D3. Although some research indicates that dosages up to 10,000 IU/day are
safe, staying below 2000 IU/day may be prudent. Concerning hypercalcemia,
consider the fact that consuming magnesium,
calcium, and D3 are synergistic (work much better together than when
taken singly). People with hypercalcemia have health issues that
may be addressed by correcting/adjusting their overall nutrient
intake/profile. In other words, most people walking this planet
are grossly undernourished. In addition, consider the fact that approximately
20 minutes of
midday sun exposure (at least 40% of skin exposed) equates to absorbing approximately 20,000 IU into
the typical Caucasian body. Those with darker skin require significantly
more exposure to get the same effect.

Dosage
and Use: One softgel daily with
fat-containing meals is suggested, or as directed by a
healthcare practitioner. Do not take with fiber
supplements.

Warnings
Information:

For dietary supplement use only

Keep Vitamin
D3 - cholecalciferol) out of reach of children

Do not exceed recommended dosage

If you have a bad reaction, discontinue use immediately

When using, please inform your
physician

If you are pregnant, lactating
or have a medical condition, consult your health care
professional before using this or any other nutritional
supplement.

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information and statements made throughout this web
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specifically noted. We
do not offer products or services for the benefits or purpose of diagnosis,
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any viral or disease condition or be free from side effects. Please, seek the advice of a competent medical
professional about anything you read on our site.