Cell culture, human sample
and rodent studies suggest serum APP770 levels could help diagnose ACS. In
cultured bone marrow endothelial cells, inflammatory cytokines or platelet
activation increased secretion of the endothelial form of amyloid precursor protein (APP), APP770, compared with
no treatment. Plasma samples from patients with acute myocardial infarction
(MI) had higher soluble APP770 levels than samples from healthy controls. In
a rat model of MI, elevation of soluble APP770 levels was detected before
elevation of a diagnostic marker currently used to detect acute MI. Next
steps could include additional biomarker validation in patient samples.

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