CACNA1CCACNA2D2CACNB1ITPR1ADRB1PRKACAPRKAR1AAGTR1PLCB1TNNC2TNNI1TNNT1TNNC1TNNI3TNNT2TNNC2TNNI2TNNT3TPM1TPM2CALM1MYLKCACNA1CCACNA2D2CACNB1RYR2CHRM2KCNJ3KCNJ5PLNATP2A2ATP1A1ATP1A2ATP1A3ATP1A4ATP1B1ATP1B2ATP1B3UnknownFXYD2KCNJ2KCNJ4KCND3KCNIP2UnknownUnknownKCNQ1KCNE1KCNE2KCNH2ALG10BABCC8KCNJ8KCNJ11UnknownKCNK1SLC8A1HCN4SCN5ASNTB2SNTB1SNTA1CACNA1HCACNA1GNifedipineInositol1,4,5-trisphosphateCalciumCalciumSodiumSodiumPotassiumPotassiumPotassiumPotassiumPotassiumPotassiumPotassiumPotassiumPotassiumPotassiumPotassiumPotassiumPotassiumPotassiumPotassiumPotassiumPotassiumPotassiumCalciumCalciumSodiumSodiumSodiumSodiumPotassiumPotassiumSodiumSodiumCalciumCalciumCalciumCalciumPIP2(16:0/20:3(8Z,11Z,14Z))DG(14:0/14:1(9Z)/0:0)AdenosinetriphosphateWaterCalciumAdenosinediphosphatePhosphateCalciumG-proteinsignallingcascadeG-proteinsignallingcascadeG-proteinsignallingcascadeMuscleContractionCreated with Snap

Nifedipine Action Pathway

Homo sapiens

Drug Action Pathway

Created: 2013-08-22

Last Updated: 2019-02-08

Nifedipine (also known as Adalat or Procardia) is a dihydropyridine calcium channel blocker that may be used for treatment of hypertension and exertion-related angina in the absence of vasospasm. Nifedipine binds the major channel in muscle cells: L-type calcium channels. Binding of Nifedipine on L-type calcium channels can change channels' confirmation to its inactive form, so that the channel couldn't faciltate the influx of calcium ions, which leads to decreased arterial smooth muscle contractility and subsequent vasoconstriction. Activated mysoin light chain kinase (MLCK) is required for muscle contraction since it can catalyze the phosphorylation of the regulatory light chain subunit of myosin. Without calcium ions in muscle cell, calmodulin couldn't form the calcium-bound calmodulin, which is required for binding and activating MLCK. Lack of initial influx of calcium can also reduce the level of contractile activity of muscle cells and results in vasodilation, which ultimately lead to overall decresing in blood pressure.

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