Research Summary

The Nuclear Magnetic Resonance (NMR) Group performs fundamental research on biological systems aimed at providing insight into the molecular mechanisms that underlie problems of environmental concern. As part of the Genome Integrity and Structural Biology Laboratory, our primary focus has been the evaluation of structural, conformational and dynamic responses of proteins to substrates, cofactors, allosteric effectors, other proteins, putative environmental toxins, nucleic acids, etc.

Major areas of research:

DNA repair complexes

HIV reverse transcriptase

Structural characterization of allergens

Current projects:

Structural and dynamic characterization of enzymes involved in DNA polymerization

Studies of nucleases, particularly focused on the proofreading exonuclease of E. coli and on the ribonuclease H domain of HIV reverse transcriptase

London received his Ph.D. in biophysics from the University of Illinois in 1973. He has published over 200 peer-reviewed articles in leading biomedical journals, and contributed 20 book chapters. He served as principal investigator of the NIH-funded National Stable Isotope Resource at Los Alamos before joining NIEHS in 1983.