In view of these findings it is likely that the involvement of other chemicals that are present in the MSE most probably explained why metabolic activation by S9 increased MSE toxicity. thai kratom for sale Interestingly whilst S9 did not potentiate MIT toxicity prolonged exposure of the cells Best Opioids Chronic Pain Laclede to MIT did appear to induce dose-dependant toxicity. The reason for this is not entirely clear. In

summary MSE and MIT do not appear to be genotoxic in MLA. This finding supports the Best Opioids Chronic Pain Laclede suggestion that there is no overt Best Opioids Chronic Pain Laclede evidence of cancer or tumour incidence upon consumptions of Mitragyna speciosa Korth leaves.

DNA replication process occurring (increased S phase cells). This finding was found to be in contrast to the previous MCL-5 results (Fig. The control cells also show a similar DNA Best Opioids Chronic Pain Laclede profile as the treated cells at the same time point. The S phase population remains activeuntil the 8 hr treatment period.

Thus it is suggested that apart from MIT there are other chemicals present in the leaves of Mitragyna specioa Korth contributing to the MSE cytotoxicity. A summary of the cytotoxic events leading to MSE or MIT induced SH-SY5Y cell death as discussed above are shown in fig. Mechanisms of MSE and MIT induced SH-SY5Y cells arrest and cell death.