Abstract

Abstract. Intertriginous candidiasis is a skin disease caused by the fungus Candida albicans. Treatment of diseases caused by Candida albicans generally uses azol antibiotics. Another alternative needs to be done by using natural ingredients that are able to treat the fungus. Red algae (Eucheuma spinosum) are known to contain carrageenan whose bioactive properties are proven to have antifungal activity. This study aims to determine the antifungal activity of red algae (Eucheuma spinosum) and determine which compounds have antifungal activity against the fungus Candida albicans. Identification of the class of compounds was carried out by phytochemical screening, red algae (Eucheuma spinosum) contained alkaloids, flavonoids and steroids. Extraction was carried out by maceration method with stratified extraction using n-hexane, ethyl acetate and methanol solvents. Antifungal activity testing was carried out by the welling method in n-hexane and methanol extracts using concentrations of 100,000 ppm, 90,000 ppm, 80,000 ppm, 70,000 ppm and 60,000 ppm. In ethyl acetate extract 50,000 ppm, 25,000 ppm, 20,000 ppm, 15,000 ppm and 10,000 ppm. Based on the results of antifungal activity tests there are no inhibitory zones and in the bioautographic TLC there are no clear zones on agar media. The results of the identification of groups of compounds by spraying specific spotting viewers such as Dragendorff, Liebermann-Burchard and AlCl3 no color change so it can not be known groups of these compounds.