Cell adhesion by aqueous extract of human placenta used as wound healer

Authors:

Nath, SangeetaBhattacharyya, Debasish

Keywords:

Anti-β1 integrinCell adhesionHuman placental extractRDG peptide

Issue Date:

Aug-2007

Publisher:

CSIR

Abstract:

Aqueous extract of human placenta, used as wound healer, has shown significant cell adhesion property on mouse peritoneal macrophages and P388D1 cultured macrophage cell line. This property was offered primarily by fibronectin type III like peptide present in the extract and is comparable to fibronectin on a molar basis. The peptide induce adhesion of cell through cell surface receptors having Kd = 2.8±0.9 x 10-5M suggesting weak binding. This is in support of integrins receptors that typically exhibit low affinities. Cell adhesion was partially inhibited by Arg-Gly-Asp (RGD) peptide, anti-β1 integrin suggesting that integrin β1 receptors have roles to play in the process.

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