"To some people that [the reel] might look like I'm completely bipolar. To the actors in this audience that shows what a lucky bitch I am," Theron, 36, joked of her wide ouevre of gritty dramas, comedies and action-adventure flicks. The Oscar-winner is a new mom and revealed on March 14 in a statement to Us Weekly that she adopted a baby boy named Jackson. "Thanks for giving me an opportunity in an industry that I love so much. And can just say if I knew that 3D was going to be such a big deal, I would have gotten that boob job 10 years ago."

After the audience quieted down from Theron's joke, she continued, "I want to thank every director, producer, actor, studio I have every had the opportunity to work with. You are only as great as the opportunities that are given to you. I want to thank everyone who has given me those opportunities, especially the last three years. I always get asked about the movie -- going experience and why people still want to go to the theater and it really truly is an opportunity for us to go through a great human experience that is as old as time."

"That’s why we are all here in Vegas together. I think we really learn from these stories," the South African beauty added. "I mean, I learned everything about love, watching 'Splash,'" she said of the 1984 romantic comedy. "That’s why I’m still single, so thanks Tom Hanks and Daryl Hannah for that. Thanks so much to my team. None of this is a single road so you don’t travel it alone so I want to thank everybody who has been crazy enough to stand by me. And I’m going to get that boob job for you.”

Theron has never been married and broke up with Stuart Townsend in January 2010 after nine years together. A source told Us of Theron's decision to adopt last month, "She has always wanted to be a mom. She is glad to be able to do it on her own now and is so happy to be a mom."