For many years endodontic dentistry has involve a series of basic rules. After pulp invasion and degradation by cariogenic bacteria, the first endodontic step include disinfection of the pulp located in the roots with sodium hypochloride or other alkaline agent. The root canal enlargement, using manual and/or the effectiveness of mechanical rotation of instrumental devices, followedthis. They contribute to the shaping of the canals, and favor the filling of the pulp space with a zinc oxide/eugenol paste, and/orcondensation in the main and accessory (secondary) canals with warm gutta-percha.

Recent development implies the possible regeneration of the radicular pulp. Residual stem cells may survive despite the dental pulp alteration or infection. Stem cells may migrate from the apical papilla. Altogether, they have the potential to regenerate the whole dental pulp, mostly when they are associated to engineered scaffolds. Induced pluripotent stem cells (iPSCs) may also contribute to pulp healing and regeneration.

Non-carious, bacteria-free alterations (destruction) of the radicular pulp [1], such as abrasion, attrition, abfraction, erosion, and/or resorption seem to play role in these processes. A series of metalloproteinases play role in the pulp degradation. In the case of cariogenic decay, pulp degradation and infection is likely due to pulp invasion by mutans streptococci and lactobacilus. These bacteria produce mostly lactic, acetic, formic and propionic acids, contributing to the degradation and destruction of the pulp. Cycles of demineralization and remineralization continue in the mouth as long as there are cariogenic bacteria, fermentable carbohydrates and salivary enzymes present in the dental pulp.