Was reminded of this while rereading the headcanon thread, and so have a few more to add.
First, the Doof Warrior from Mad Max: Fury Road. Possibly the most badass blind man since Zatoichi. He may be working for the villain, but you can't help but love a guy who plays a flamethrowing guitar. See you in Valhalla, you crazy-awesome dude.
Second, a couple of characters from RWBY. (A series, incidentally, that a flamethrowing guitar would be right at home in.) Due to injuries sustained in a fight with his father, Mercury Black lost his legs from the midthigh-down. But considering his prosthetic legs have guns built in, I don't think he has any complaints.
Also, Yang has her right arm severed just above the elbow at the end of Volume 3. No word yet on whether she'll get some sort of weaponized prosthetic replacement yet.
Third, in a weird way, Shockwave from Transformers, at least the G1 incarnation. After all, he only has one eye, and one hand. (Although the other arm ends in a laser cannon, he still can't pick things up with that.)

Last edited by emmjay on Fri Nov 17, 2017 7:07 am, edited 1 time in total.

I don't know if this counts as notable per se, but I just watched a movie on Amazon about a killer mime called Silent But Deadly, and it featured a woman with a prosthetic arm in it. Since it was a meta sendup of slashers she was a total archetype of the final girl with a sad backstory, but her actual handicap was (pleasantly) surprisingly not the subject of mockery and the closest thing to a joke at her expense in that respect was actually a pretty badass moment where she clocks a guy with her arm after disconnecting it from her shoulder.