Compared with control group, apoptotic cell numbers of the apoptotic outer nuclear layer cells were obviously reduced after 7,14,21,28 d and 35 d, and the Bcl-2 expression in the matrix of retinal photoreceptors and photoreceptor outer segments were obviously increased after 3, 7,14,21,28 d and 35 d in experimental group in rd mice.

[Methods] The model of retinal ischemia-reperfusion was emploied by ligationed the left side of artery, the rats were devided into ischemia-reperfusion group, ischemia-reperfusion and puerarin group and control group, each group including 1 h, 6 h, 12 h, 24 h, 48 h and 72 h.

RESULTS At 3,7,15 days after the ischemia reperfusion injury,the activity of SOD in Yiqimingmu solution low and high dose group were higher than in the model control group(P<0.05), the content of MDA in Yiqimingmu solution high dose group were lower than in the model control group(P<0.05).

At the early stages of retina development, the neuroepithelial cells divide synchronously, thus leading to the accumulation of a certain number of the retinal rudiment cells.

Synchronous divisions precede the asynchronous ones, when the differentiation of the retinal cells is initiated.

The multipotent cells of the retinal ciliary-terminal zone and cells of the pigment epithelium in the eye periphery provide for the growth of amphibian and fish eyes during the entire life of these animals.

The main event of retinal regeneration in newts is the transdifferentiation of the pigment epithelium cells.

Obesity lias been produced in male mice by the injection of gold thio-glucose ( GTG ) or mercury thioglucose. Histological examination confirmed tbe destruction of the ventromedial nuclei in the mice treated with these two drugs, Sodium thioglucose was found to be able to prevent the GTG-induced damage and obesity development. At the end of the thirteenth week after injections of GTG, the weights of the inguinal fat pads of the treated mice were greatly increased as compared with the untreated mice. In GTG-treated...

Obesity lias been produced in male mice by the injection of gold thio-glucose ( GTG ) or mercury thioglucose. Histological examination confirmed tbe destruction of the ventromedial nuclei in the mice treated with these two drugs, Sodium thioglucose was found to be able to prevent the GTG-induced damage and obesity development. At the end of the thirteenth week after injections of GTG, the weights of the inguinal fat pads of the treated mice were greatly increased as compared with the untreated mice. In GTG-treated mice, there was a distinct increase in glucose absorption from the intestine as measured in vivo. Since obesity is accompanied by hyperinsulinaemia, we would conclude that increased intestinal absorption of glucose in the GTG-obesity mice was related with insulin. The intestinal absorption of glucose in the alloxan-diabetic rats was greatly decreased as measured in vivo. But the glucose absorption of the alloxan-diabetic rats was not decreased as measured in vitro. There was a linear relationship between the blood sugar level and the absorptiverate of glucose. The insulin control was not in a direct manner to theactive transport system for glucose but an indirect manner, probably secondary to the changes of blood sugar level. Besides, the obese rats were accompanied by hyperinsulinaemia as measured by the serum RIA method and the gastrocnemius muscle capacity of the obese rats was decreased as compared with control rats. Experimental animal models can also be produced by insulin or monosodium glutamate.

Thirteen vasectomized rabbits were randomized into 2 groups: the vasectomy stock diet (V-S) group and the vasectomy cholesterol diet (V-Ch) group. Twen-ty male rabbits of the same age were divded into corresponding control stock diet (C-S) group and control cholesterol diet (C-Ch) group. The principal results are as follows: the incidence of arteriosclerotic retinopathy was 14. 3% in V-S and 16.7% in C-S, and 66.7% in V-Ch and 83.3% in C-Ch. There was neither statistical difference between V-S and C-S, nor between...

Thirteen vasectomized rabbits were randomized into 2 groups: the vasectomy stock diet (V-S) group and the vasectomy cholesterol diet (V-Ch) group. Twen-ty male rabbits of the same age were divded into corresponding control stock diet (C-S) group and control cholesterol diet (C-Ch) group. The principal results are as follows: the incidence of arteriosclerotic retinopathy was 14. 3% in V-S and 16.7% in C-S, and 66.7% in V-Ch and 83.3% in C-Ch. There was neither statistical difference between V-S and C-S, nor between V-Ch and C-Ch (P> 0.05 in both). There was a positive correlation between the degree of arteriosclerotic retinopathy and the level of serum cholesterol, and there was no correlation between the degree of arteriosclerotic retinopathy and the titre of serum antiserum autibody.

The indtiction of photic retinal injury model was carried out by exposing rats to intense fluoresence light(2 5 0 foot-candle)for 24 hours。Lycium barbarum L。was fed to treated rats before,during and after light exposure。We found that rods and cones of retina in control rats were severely in-jured.The number of nucleus in ONL was significantly decreased,and the degeneration and necrosis of RPE was also noted.In treated rats,the rods and cones were nearly normal.The number of photore-ceptot nucleus was slightly...

The indtiction of photic retinal injury model was carried out by exposing rats to intense fluoresence light(2 5 0 foot-candle)for 24 hours。Lycium barbarum L。was fed to treated rats before,during and after light exposure。We found that rods and cones of retina in control rats were severely in-jured.The number of nucleus in ONL was significantly decreased,and the degeneration and necrosis of RPE was also noted.In treated rats,the rods and cones were nearly normal.The number of photore-ceptot nucleus was slightly decreased。The results of morphologic and morphometric studies showed that Lycium barbarum L。could preserve the outer nuclear layer,rods and cones and RPE cells signifi-cantly。