METHODS OF TREATING MUSCULAR DYSTROPHY
Disclosed herein are methods of improving muscular health, such as enhancing muscle regeneration, maintenance, or repair. In some examples, the method includes administering to the subject an effective amount of an agent capable of incre...

GLYCINE TRANSPORTER INHIBITOR
The present invention provides a novel compound represented by formula (IA) or a pharmaceutically acceptable salt thereof, which is useful for prophylaxis or treatment of diseases such as schizophrenia, Alzheimer's disease, cognitive imp...

PROCESS FOR PREPARING AMPHIPHILIC PEPTIDE DERIVATIVES
The present invention relates to novel derivatives of hydrophilic bioactive peptides which have been modified by introducing a lipophilic substituent through esterification of the free carboxylic group(s) of the peptide with an aliphatic...

BENZOTHIOPHENE COMPOUND
The inventors perfected the present invention as a result of a study into IK1 channel activators and a confirmation that a benzothiophene compound exhibits efficacy against visceral pain, inflammatory pain, osteoarthritic pain, neuropath...

WO/2014/190866A1

MUSCLE STEM CELL IN VITRO CULTURE METHOD AND APPLICATION
Provided is a muscle stem cell in vitro culture method. A muscle stem cell is cultivated in vitro by using a cell culture medium of a cell factor added with a blood cell or a conditioned medium of the blood cell. Also provided are a cult...

WO/2014/189634A1

ANGIOTENSINS IN MUSCULAR DYSTROPHY
The present invention provides, among other things, methods of treating a muscular dystrophy including administering to a subject suffering from or susceptible to a muscular dystrophy an angiotensin (1-7) peptide. The present invention i...

WO/2014/188198A1

TACROLIMUS AND ANALOGUES THEREOF FOR MEDICAL USE
The present invention relates to a method of treating adverse fat accumulation and related conditions with very low doses of tacrolimus or a close structural analogue thereof. In particular this invention relates to treating adverse fat ...

TOPICAL COMPOSITION WITH GINGER
A topical pharmaceutical composition for use in alleviating or reversing a clinical symptom selected from rigidity, stiffness, loss of mobility, loss of flexibility and swelling in a part or region of the body is described, wherein the c...

WO/2014/188730A1

MOTILITY FUNCTION-IMPROVING AGENT
Provided is an agent for oral ingestion whereby human motility function can be improved. A motility function-improving agent that comprises lutein and a milk component as active ingredients, said motility function-improving agent being u...

CALCIUM CHANNEL AGONISTS
Embodiments of calcium channel agonists, as well as methods of making and using the calcium channel agonists, are disclosed. The disclosed calcium channel agonists and corresponding salt forms have a structure according to general formul...

WO/2014/183989A1

ACTIVE SUBSTANCE FOR TREATING SARCOPENIA
The present invention relates to collagen hydrolysate as active substance for treating sarcopenia, as active substance against the degenerative loss of muscle mass and for improving muscle power, as active substance for reducing the age-...

HETEROCYCLIC COMPOUND
The purpose of the present invention is to provide: a compound having excellent PKC inhibitory activity and is useful as a prophylactic or therapeutic agent for immunologic diseases and inflammatory diseases, etc.; or a salt thereof. The...

NOVEL ANTI-HUMAN TWEAK ANTIBODY
[Problem] To provide an anti-human TWEAK antibody having superior activity as compared to conventional anti-human TWEAK antibodies, and a means for preventing or treating various diseases in which human TWEAK is involved in the pathogene...

COMPOSITION FOR PREVENTING JOINT AGING
The present invention provides a composition for preventing joint aging, containing one or more types of components selected from the group consisting of a component containing rehmannia root, a component containing cornus fruit, a compo...

TREATMENT OF CATAPLEXY
The present invention relates to a method of treating cataplexy in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of certain carbamate compounds.

WO/2014/157437A1

PROPELLANE DERIVATIVE
A propellane derivative represented by general formula (I) (wherein R1 represents a hydrogen atom, a C1-6 alkyl group, a cycloalkylalkyl group (wherein the number of carbon atoms in a cycloalkyl moiety is 3 to 6 and the number of carbon ...

WO/2014/157380A1

THERAPEUTIC AGENT FOR WOUNDS OR FIBROSIS
Provided is a means whereby wounds or organ fibrosis can be easily treated within a short period of time. A therapeutic agent for wounds or fibrosis, said therapeutic agent comprising a substance capable of specifically inhibiting the ex...

WO/2014/157436A1

PHARMACEUTICAL COMPOSITION FOR EXTERNAL APPLICATION
[Problem] The purpose of the present invention is to provide a formulation technique for improving the percutaneous absorption of diclofenac and/or a pharmaceutically acceptable salt thereof with respect to a pharmaceutical composition f...

PYRAZOLE DERIVATIVES AS PRMT1 INHIBITORS AND USES THEREOF
Described herein are compounds of Formula (I-a) and (I-b), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT1 activity. Methods of using ...

WO/2014/148574A1

INHIBITION OF PRODUCTION OF IL-2
The purpose of the present invention is to find a substance capable of inhibiting the production of IL-2. The production of IL-2 can be inhibited with a compound represented by general formula (I) (wherein R1 to R4 and A are as defined i...

APPLICATION OF PHTHALIDE COMPOUND
An application of a phthalide compound in preparing a medicament. The medicament is specially used for promoting a stem cell to secrete one of the following items: telomerase, a neurotrophic factor (brain-derived neurotrophic factor, BDN...