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add an external mouse/keyboard to fix the onboard fault.
check the device manager for any yellow exclamation marks. as there may be a faulty or corrupt. keyboard/mouse touchpad driver.
other option, is to add remove touchpad drivers, and re-install.
finally, you could check if the settings are correct in the bios.

1. Press Fn + F9 to enable the touchpad.
This key combination acts as a switch, enabling or disabling the touchpad: press once to enable (if it is disabled), then press again to disable.

2. If the touchpad still doesn't respond, check the settings in the mouse control utility.
Click on the touchpad icon on the right side of the task bar if you see one or click Start button/Settings/Control Panel, select the Mouse icon and Press Enter.
Change the settings if necessary.

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Press the "Fn" and "F9" keys simultaneously.Test your touchpad. If it works, it was simply disabled. Press the same key combination any time you want to toggle your touchpad on or off.Plug an external mouse into a USB port on your laptop if the key combination didn't work. Follow onscreen prompts to install the mouse driver--if necessary. You can also move the cursor using the "Tab" key and the arrow keys, as well as click by pressing "Enter" until the mouse is operational.
Click the link in the Resources section if you are using a Toshiba Satellite with Windows Vista. Follow the onscreen prompts to download and re-install the driver.
Open a web browser and navigate to Synaptics.com if you have a different Toshiba model or operating system. Synaptics brand touchpads are used in all Toshiba laptops, and this site provides a generic driver.Hover your mouse over "Support" on the top menu, then select "Drivers" from the drop-down menu.Select your operating system from the list provided and download the generic driverFollow the onscreen prompts to install your new driver, and then test the touchpad again. If it still does not work, take your laptop to a licensed repair technician.

Try reinstalling the touchpad driver.
You can download the
touchpad and device drivers for your model laptop from the Toshiba WEB site from their
download page. Make sure you enter the model of your laptop so you can get the
correct drivers. Please click on this link: - http://www.csd.toshiba.com/cgi-bin/tais/support/jsp/home.jsp

1) Examine your "Function"/"F" keys
and look for a touchpad icon. If you find one, hold the "Fn" key and
press the touchpad icon button to unlock the touchpad. Move on to Step 2
if your laptop doesn't support this feature.

2) Plug a USB mouse into an open
port on your laptop. Click the Windows "Start" button. Click "Control
Panel" in Windows XP and double-click "Device Manager." Type "Device" in
the search box in Vista and Windows 7 and click "Device Manager" from
the results.

3) Click "+" next to "Mice and
other pointing devices." Right-click the touchpad and select "Enable."
Your touchpad is now unlocked.

You will see several search results, just click the topmost result which says "Mouse pointer jumpsaround as youtype". You will then see a detailed guide on how to adjust touchpad settings. Hope this works for you.

You might need a palmrest/touchpad replacement. Check the touchpad cable connection on the motherboard first. Remove it and reinsert in its place. If still not working you have to replace the assemble.

Go to the 'start' button and then hit the 'control panel' option, then click 'mouse' then go to 'Device Settings' and then to the 'settings'. When you get to this screen it shows a list on lthe left hand side choose the 'tapping' option and then ok.