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Claims for Patent: 9,339,615

Claims for Patent: 9,339,615

Title:

Dry powder inhaler and system for drug delivery

Abstract:

A breath-powered, dry powder inhaler, a cartridge, and a pulmonary drug delivery system are provided. The dry powder inhaler can be provided with or without a unit dose cartridge for using with the inhaler. The inhaler and/or cartridge can be provided with a drug delivery formulation comprising, for example, a diketopiperazine and an active ingredient, including, peptides and proteins such as insulin and glucagon-like peptide 1 for the treatment of diabetes and/or obesity. The dry powder inhaler is compact; can be provided in various shapes and sizes, colors, and comprises a housing, a mouthpiece, a cartridge placement area, and a mechanism for opening and closing the medicament cartridge. The device is easy to manufacture, provides a pre-metered single unit dose, it is relatively easy to use, and can be reusable or disposable.

1. A dry powder medicament cartridge for an inhaler, comprising: an enclosure configured to hold a medicament; at least one inlet port to allow flow into the enclosure, and at least
one dispensing port to allow flow out of the enclosure; wherein the at least one inlet port is configured to direct at least a portion of the flow entering the at least one inlet port at and across the at least one dispensing port within the enclosure
in response to a pressure differential, wherein the inlet port is in close proximity to the at least one dispensing port along a horizontal axis and a vertical axis.

3. The dry powder medicament cartridge of claim 2, wherein the active ingredient is a hormone, an anticoagulant, an immunomodulating agent, a vaccine, a cytotoxic agent, an antibiotic, a vasoactive agent, a neuroactive agent, an anaesthetic,
sedative, a steroid, a decongestant, an antiviral, an antisense, an antigen, or an antibody.

10. The dry powder medicament cartridge of claim 1, wherein the cartridge comprises one or more colors or markings to identify the medicament.

11. A dry powder medicament cartridge for an inhaler, comprising: an enclosure configured to hold a medicament having one or more exit ports configured to have a smallest dimension less than 3 mm to exclude release of larger powder aggregates
and wherein at least one inlet port and the one or more exit ports are in close proximity along a horizontal axis and a vertical axis.

13. The dry powder medicament cartridge of claim 12, wherein the active ingredient is hormone, an anticoagulant, an immunomodulating agent, a vaccine, a cytotoxic agent, an antibiotic, a vasoactive agent, a neuroactive agent, an anaesthetic,
sedative, a steroid, a decongestant, an antiviral, an antisense, an antigen, or an antibody.

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