Molecular Cancer Therapeutics: Strategies for Drug Discovery and Development

Molecular Cancer Therapeutics covers state-of-the-art
strategies to identify and develop cancer drug target molecules and
lead inhibitors for clinical testing. It provides a thorough
treatment of drug target discovery, validation, and development.
The introductory chapters provide an overview of pathways to
discovery and development of molecular cancer therapeutics.
Subsequent chapters progress from initial stages of drug target
discovery to drug discovery, development, and testing in
preclinical and clinical models. Topics include drug lead
screening, drug-to-lead development, proof-of-concept studies,
medicinal chemistry issues, intellectual property concerns, and
clinical development.
This invaluable reference promotes understanding of steps involved
in developing drug leads for industrial partnering and development.
It provides an overview of the strategies for discovery and
validation of drug target molecules, and discusses cell- and
molecule-based drug screening strategies, as well as mouse models
for cancer. Coverage also includes how to refine drug leads for
suitability in clinical testing, the special issues of clinical
testing of molecular-targeted drugs, and intellectual property
concerns.

"…this little book represents the ever-so-important 'and'
that links research and development together in a logical and
thoughtful manner...a valuable resource for scientists and
clinicians alike…" (New England Journal of Medicine,
January 27, 2005)

"...an excellent publication.… I recommended it for
libraries...those involved in cancer research...those who teach
pharmacy and medical students about drugs used in the treatment of
cancer." (The Annals of Pharmacotherapy, December 2004)

"…provides an up-to-date overview of the different phases
of drug discovery and preclinical development of experimental
cancer principles.” (Drug Discovery & Development,
September 2004)

"…a most informative book, discussing the important
evolution in the field of cancer therapeutics…" (American
Journal of Therapeutics, July/August 2004)

Digital version available through Wiley Online Library

Permissions

To apply for permission please send your request to permissions@wiley.com with
specific details of your requirements. This should include, the Wiley title(s), and the specific portion of the content you wish to re-use
(e.g figure, table, text extract, chapter, page numbers etc), the way in which you wish to re-use it, the circulation/print run/number of people
who will have access to the content and whether this is for commercial or academic purposes. If this is a republication request please include details
of the new work in which the Wiley content will appear.