Sirtuin 1, encoded by the SIRT1 gene in humans, is a member of a protein family that is homologous to yeast Sir2 protein. Sirtuins are grouped into four classes, with sirtuin 1 belonging to class 1. The functions of human sirtuins are not known; however, they are thought to be intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. In yeast, sirtuin 1 exhibits histone deacetylase activity. Induction of sirtuin 1 gene expression in mice increases insulin sensitivity, suggesting a role in management of type 2 diabetes. Sirtuin 1 is also known as sirtuin (silent mating type information regulation 2, S. cerevisiae, homolog) 1; SIR2L1, hSIR2, hSIRT1, SIR2-like protein 1, SIR2alpha, NAD-dependent deacetylase sirtuin-1, sir2-like 1, and sirtuin type 1.

This product is an affinity-purified IgG antibody that recognizes human sirtuin 1 protein. The antibody was raised in rabbit using a synthetic peptide and can be used for Western blot (WB) detection, immunohistochemical (IHC) detection, or immunoprecipitation (IP) of human sirtuin 1 protein.