High Blood Pressure (Hypertension)

Severe Potential Hazard, High plausibility

erythropoiesis-stimulating agents - hypertension

The use of erythropoiesis-stimulating agents is contraindicated in patients with uncontrolled hypertension. Epoetin alfa and darbepoetin alfa may cause blood pressure to rise. Hypertensive encephalopathy and seizures have been observed in patients with chronic renal failure treated with these agents. Blood pressure should be adequately controlled prior to initiation of therapy, and monitored closely during treatment. Aggressive antihypertensive measures may be necessary, particularly early on in treatment when the hematocrit is increasing. It is recommended to reduce or withhold the use of these agents if blood pressure becomes difficult to control.