Application:

Positioning: The main application for Virosart® Max* is the protection of the final virus retentive membrane. For that purpose this filter is used at the end of the purification process in-line with the final virus filtration step of the biopharmaceutical product. The optimized pre-filter – final-filter ratio should be determined during development of the virus filtration step.

Working principle: Virosart® Max* combines size exclusion mechanism with efficient adsorptive capacities to increase the robustness of the following virus filtration step. The most challenging molecules for the final virus retentive membrane are aggregates and | or small hydrophobic molecules. Virosart® Max binds aggregates very efficiently through hydrophobic interactions, independently of process conditions such as conductivity.