Matrix protein p17 targets Gag and Gag-Pol polyproteins to the plasma membrane via a multipartite membrane binding signal, that includes its myristoylated N-terminus. Also mediates nuclear localization of the preintegration complex. Gag-Pol polyprotein and Gag polyprotein may regulate their own translation, by the binding genomic RNA in the 5'-UTR. At low concentration, Gag-Pol and Gag would promote translation, whereas at high concentration, the polyproteins encapsidate genomic RNA and then shut off translation.

Cell Types

Ubiquitous

Protein Location

Matrix protein p17

Titer

1x106pfu/mL

Storage

DMEM with 2.5% glycerol

Caution

This product is for research use only and is not intended for therapeutic or diagnostic applications. Please contact a technical service representative for more information.

Material may be irritating to mucous membranes and upper respiratory tract. May be harmful if inhaled.

Signs and Symptoms of Exposure
To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.

Section 12: Ecological Information

N/A

Section 13: Disposal Considerations

Contact a licensed, professional waste disposal service to dispose of this material. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. Observe all federal, state/provincial, and local environment regulations.

Section 14: Transport Information

DOT
Proper Shipping Name: None
This substance is considered to be non-hazardous for transport.

IATA
This substance is considered to be non-hazardous for air transport.

Section 15: Regulatory Information

United States Regulatory Information
SARA LISTED: No

Canada Regulatory Information
WHMIS Classification: This product has been classified in accordance with the hazard criteria of the CPR, and the MSDS contains all the information required by the CPR.
DSL: No
NDSL: No

Section 16: Other Information

The information contained in this Material Safety Data Sheet is believed to be accurate, but it is the responsibility of the user or supplier to determine the applicability of these data to the formulation of necessary safety precautions.

Applied Biological Materials Inc. shall not be held responsible for any damage resulting from the use of the above product or the information contained in this Material Safety Data Sheet.