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World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar. Best Paper Award : Dr. Muhammad Baqir MR Fakhrildin
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Abstract

The present research study is aimed at developing and characterizing
the influence of solubilizing agent such as tween 80 and dimethyl
sulfoxide (DMSO) on the morphological and physicochemical
characteristic of fast dissolving orodispersible films (FDOF). Pullulan
is used as film forming polymer and glycerine was incorporated as
plasticizing agent. The embodiment of atenolol as antihypertensive
drug, in FDOF was achieved by solvent casting technique. Atenolol is
β1 blocker, prescribed widely in diverse cardiac abnormalities.
Literature reports that faster disintegration leads to optimum drug
release resulting in higher bioavailability. The present research work
also attempts to correlate the effect of concentration of pullulan and
solubilizing agent on the disintegration time and drug release profile.
The atenolol FDOF were characterized for physical appearance, deformation caused during
removing from die cavity, disintegration time, in vitro dissolution, etc. The optimum
concentration of plasticizer, polymer and solubilizing agent was developed on the basis of
flexibility, tensile strength and stickiness of the film. In the presence of solubilizing agent the
morphological characters was found to be better than in its absence. Atenolol FDOF showed
optimum drug content and folding endurance. The disintegration time of formulation PUD7
film was found to be 10 sec with in vitro release of 99.27 % in 90 sec, which was better than
other prepared formulations. Drug-excipients interaction studies performed using FTIR;
showed no interaction. Surface pH was found to be neutral, indicating safety of
administration. Atenolol FDOF formulated using DMSO showed optimum results as
compared to tween 80 and FDOF without solubilizing agent. Thus based on the results it can be concluded that the FDOF formulated using solubilizing agents can enhance the disintegration time and drug release profile.