Ever since he was young, Sam Winchester (Jared Padalecki, Gilmore Girls) has tried to escape his past. After his mother’s mysterious death, Sam’s father set out to seek revenge on the evil forces that killed her and destroy other evil beings along the way. Unlike Sam, Dean (Jensen Ackles, Smallville), Sam’s older brother, was eager to follow in his father’s footsteps, learning the tricks of the trade, and entering the “family business." Sam on the other hand, determined to break free of the “family business”, left home as soon as he graduated from high school, unwavering from his quest to start a “normal” life on his own.

Just as Sam’s new life was going perfectly with an upcoming interview at a prestigious law school and a beautiful girlfriend by his side, Dean arrived at Sam’s doorstep to let his brother know that their father (recurring guest star Jeffrey Dean Morgan) disappeared on a hunting trip. Upon hearing the startling news, Sam, though reluctant, had no choice but to help Dean track down their father.

Now, on the road together in search of their father, tracking evil supernatural forces along the way, Dean and Sam have begun to reunite after spending several years apart. However, during their journey, old sibling rivalries resurface, and the effects of their strange upbringing are shown. Sam remains wary of their father and mission while Dean, although cocky and fearless on the surface, still tries to come to grips with his mother’s horrific death. But together with their different views and personalities, Sam and Dean are able to save lives by destroying the evil beings that haunt the earth.

Despite Dean's directive to forget about looking for a cure for the Mark of Cain, Sam continues to do research. Dean suspects Sam is hiding something but decides to focus on a new murder case where they run into Cole. The three team up and learn a Khan worm is infecting men and turning them into murderers. Unfortunately, the worm makes it's way into Cole.

10x14: The Executioner's Song recap: A death-row prisoner is in his cell staring up at the ceiling as the guard comes by. The prisoner, Tommy Tolliver, asks if there has been any mail for him. The guard says that there's the usual, and Tommy asks him about his wife, Amanda. He says that his fourth victim was an Amanda and offers to kill the guard's wife the same. The guard says that Tommy will be dead in two weeks and walks out... read more.

10x13: Halt & Catch Fire recap: In Spencer, Iowa, Billy Bass and Janet Novoselic are out driving and Billy checks with his navigational app, Trini. He asks for directions to a taco house, and Trini leads them off the beaten path. The inside of the truck turns suddenly cold as they come to a bridge that is closed for repairs. When Billy asks for a different route, Trini tells him to go ahead. It then tells Janet to get out of the truck and she hastily gets out. The car doors lock, trapping Billy, and the truck speeds off the bridge... read more.

10x12: About a Boy recap: At a bar in Pendleton, Oregon, two men fight and the bartender throws the other one, J.P., out into the parking lot. A homeless man stares at J.P. and then wanders off, and J.P. goes to his car. As he fumbles with the keys, a man comes up behind him and grabs the hex bag hanging from his neck. The homeless man sees a flash of white light and runs over, but all he finds is J.P.'s empty clothing... read more.

10x11: There's No Place Like Home recap: At a suburban home in Topeka, Peter Harper screams and runs downstairs as something throws objects at him. He runs outside and trips over a hose as the automatic lights come on. Bleeding, Harper looks back and confirms that his pursuer is nowhere to be seen. However, when he gets up, a woman is standing for him in the shadows. Harper insists that he doesn't know anything else, and Charlie steps out of the shadows and says that she knows... but she's going to torture him anyway... read more.

10x10: The Hunter Games recap: Crowley walks through a long corridor and two demons come after him. He turns to run but more demons surround and stab him..... read more.