Cytosine methylation at CpG dinucleotides is a semistable epigenetic marker critical to the normal development of vertebrates. Abnormal levels of methylation are associated with a host of human diseases and disorders, and many diagnostic tools...

Methylated DNA binding proteins (MDBP) are a unique class of sequence-specific DNA-binding proteins present ubiquitously in mammalian cells. A subset of the MDBP-binding sites are methylation-dependent sites, and MDBP binds better to these sites...

"Hydrophobic hydration of non polar molecules is the principal driving force that dictates several interfacial phenomena in nature such as self assembly of surfactant molecules, fate of environmental pollutants, wetting of surfaces, solution...

Triple-negative breast cancer (TNBC) accounts for 15% of all diagnosed breast cancers nationally and affects African-American women 3 times more likely than any other ethnic group. Locally, African-American women in the New Orleans area see higher...

Restriction enzyme Taq I was able to cleave four highly modified DNAs from bacteriophage T4, XP12, PBS1 and SP15. The relative ability of cohesive-ended TaqI fragments of these DNAs and of normal (lamda) DNA to be ligated by T4 DNA ligase was as...

MicroRNAs (miRNAs) are small non-coding 18-22 long RNAs, which act as key mediators in many cellular processes involved in tumorigenesis including proliferation, differentiation, invasion, and apoptosis. miRNAs repress gene expression by inhibiting...

Two sequence-specific endonucleases, XorI and XorII, have been partially purified from Xanthomonas oryzae. XorI and XorII were shown to be isoschizomers of PstI and PvuI, respectively. X. oryzae is a particularly good source of this PvuI...