Envisioned by Cognigen Corporation, a Simulations Plus (Nasdaq:SLP) company, in 2003, the Pharma of the FutureSM (PoF) program was conceived as a research and training initiative to design and implement the workflows and computer systems required to support modeling and simulation (M&S) activities. The numerous M&S projects performed by Cognigen scientists became a source of raw material for research initiatives designed to improve the quality, timeliness, and impact of M&S results. These research initiatives have yielded numerous benefits, including:

PK and Exposure-Response Model Development

Using population-based pharmacokinetic models, we can characterize drug disposition using sparse drug concentration data in patients with the condition of interest, whereas characterizing the relationships between drug exposure and patient response is done using exposure-response models. By gaining this understanding, we can support the selection or justification of dosing strategies, determine the maximum tolerated dose or the minimum effective dose, and characterize sub-population differences or drug-drug interaction effects for inclusion in the drug’s labeling information.

The best company in the world, pharmacometrically speaking.

Changing the world of drug development.

At Cognigen, you’ll work side-by-side with leading pharmaceutical and biotechnology companies. Each year we evaluate 30 to 40 drugs. In fact, annually 25% of the compounds we work on are submitted to regulatory agencies where our work for dose selection and justification is an integral part. It’s that kind of success that has earned Cognigen a tremendous amount of credibility within the pharma and biotech industries – a reputation we invite you to be a part of.

There’s no “I” in “development.”

On each project, you’ll collaborate with a group of hand-picked individuals, each bringing a specific skill to the table. There’s PK/PD scientists, clinical pharmacologists, statisticians, software developers, data programmers, project managers, technical writers, and administrative staff. Through experience, we’ve found this organization helps create the ideal environment where ideas are generated, problems are solved, and creativity is inspired.

Good times will be had.

Fun is as much a part of our work environment as data analysis and automating our solutions. We have theme lunches, family picnics, holiday parties, ice cream socials, grill days, and baseball game outings. And we’ve been known to have spontaneous tournaments of trashcan Frisbee (a classic Buffalo tailgating game).

Harness the power of pharmacometrics.

Raise your hand if you wish there was a way to make drug development more efficient. Guess what? There is. It’s called model-based drug development, and it involves using quantitative analysis to better design protocols, determine dosage levels, and figure out other neat stuff that lead to successful regulatory filings. Once you see how incredible (and cost-effective) pharmacometrics can be, you’ll be hooked.