After nearly two years of dating, Bradley Cooper and Renee Zellweger have split, according to Us.

Zelleweger, 41, and Cooper, 36, met six years ago while they were filming Case 39, however the two didn't become a romantic item until the summer of 2009.

Just last week, Cooper gave Zellweger a shout out while appearing on Inside the Actors Studio. X17 photogs recently snapped pics of Cooper getting touchy-feely with Jessica Biel in between takes on the set of New Year's Eve, and it appears their close friendship might've caused the breakup between Biel and beau Justin Timberlake.

Reps for both Cooper and Zellweger have not returned requests for comment.

Both Renee and Bradley were previously married. Find out to whom ... after the jump.

Cooper was previous married to actress Jennifer Esposito and Zellweger was briefly married to country artist Kenny Chesney.