Griffin "will no doubt continue (Rivers') legacy and do the series justice by bringing her own unique comedic style and tell-it-like-it-is personality to the host chair," said E! executive VP Jeff Olde.

The show also announced that it was bringing in Bravo star Brad Goreski, of "It's a Brad Brad World," to round out the show's panel.

Series regulars Kelly Osbourne and Giuliana Rancic remain in place in their second and third banana roles.

Melissa Rivers, Joan's daughter, was also staying put as the show's executive producer.

"Kathy just feels right, and Brad brings a fun, new voice to join Giuliana and Kelly in this ensemble," Rivers said in a statement.

Kathy Griffin, right, was rumored to be the frontrunner for the ‘Fashion Police’ hosting gig left empty by the death of Joan Rivers, left. (DAN STEINBERG/AP)

The announcement of Griffin's involvement comes after an apparent about-face by the 54-year-old stand-up and TV host.

Earlier this month, Griffin admitted E! had approached her about her late mentor's gig, but said she wasn't sure she wanted it.

"I don' t know if the situation is correct at this time for me or right for me at this time," she told "Access Hollywood" at an event in Beverly Hills on Nov. 4.

The show, which is in its fifth season, featured Rivers and her cohorts dishing on celebrity fashion choices, often after awards shows such as the Oscars and the Emmys.