0. DOCID:18747 SCORE: 0.00429492230526342DOCNO: 2224844OWNER: NLMSTATUS: MEDLINEDESCRIPTOR: Cell DifferentiationQUALIFIER: physiopathologyQUALIFIER: physiologyQUALIFIER: physiologyAUTHOR: Y S Cho-Chung YSAFFILIATION: Cellular Biochemistry Section, National Cancer Institute, NIH, Bethesda, Maryland 20892.PUBTYPE: Journal ArticlePUBTYPE: ReviewJOURNALTITLE: Cancer research. COUNTRY: UNITED STATESTITLE: Role of cyclic AMP receptor proteins in growth, differentiation, and suppression of malignancy: new approaches to therapy.PUBDATE: 19901101
Two isoforms of the regulatory subunits of cyclic AMP (cAMP)-dependent protein kinase that bind cAMP are inversely expressed during ontogeny and cell differentiation. These cAMP-binding receptor proteins in harmony may regulate the growth of normal cells and their differentiation into nondividing states. Cancer cells can also be made to differentiate and stop growing when the functional balance of these cAMP receptor proteins is restored by treatment with site-selective cAMP analogues or by the use of an antisense oligodeoxynucleotide, suggesting new approaches to cancer treatment.

1. DOCID:18699 SCORE: 0.00393254545843047DOCNO: 1998233OWNER: NLMSTATUS: MEDLINEQUALIFIER: therapyAUTHOR: A K Jakobsen AKAUTHOR: K Bertelsen KAUTHOR: B Andreasson BAUTHOR: P Bichel PAUTHOR: J J Christensen JJAUTHOR: I S Christophersen ISAUTHOR: S A Engelholm SAAUTHOR: H Havsteen HAUTHOR: M Hjelm-Hansen MAUTHOR: F Jensen FAFFILIATION: Onkologisk afdeling, Arhus Kommunehospital.PUBTYPE: Journal ArticlePUBTYPE: ReviewJOURNALTITLE: Ugeskrift for laeger.COUNTRY: DENMARKTITLE: [Treatment of cervix cancer in Denmark]PUBDATE: 19910101
The current status of cervical cancer treatment in Denmark is discussed. Diagnostic aspects and problems of classification are presented briefly supplemented with a comment on new prognostic parameters based on a semiquantitative score system and flow cytometry. Surgery is the treatment of election for the early stages whereas radiotherapy is the treatment of choice in advanced stages. Chemotherapy should only be employed in the framework of clinical trials. It is concluded that centralised treatment should be maintained.

2. DOCID:17343 SCORE: 0.00377379783205755DOCNO: 1813556OWNER: NLMSTATUS: MEDLINEDESCRIPTOR: Ciliary BodyQUALIFIER: diagnosisQUALIFIER: diagnosisQUALIFIER: diagnosisQUALIFIER: diagnosisQUALIFIER: diagnosisAUTHOR: T K Wilcox TKPUBTYPE: Case ReportsPUBTYPE: Journal ArticleJOURNALTITLE: Journal of the American Optometric Association. COUNTRY: UNITED STATESTITLE: Case report: ciliary body melanoma with extrascleral extension.PUBDATE: 19910701
Uveal melanoma is an uncommon cancer that is most often diagnosed in the sixth decade and is somewhat more common in males. Early detection and treatment of melanoma is important as metastasis can be fatal. A case of ciliary body melanoma that was detected in an asymptomatic patient because of extrascleral extension is presented. Signs and symptoms that may lead to the diagnosis of uveal melanoma are presented, as well as lesions that may simulate extrascleral extension of melanoma.

3. DOCID:18643 SCORE: 0.00374693499265719DOCNO: 1608657OWNER: NLMSTATUS: MEDLINEQUALIFIER: geneticsQUALIFIER: physiologyQUALIFIER: geneticsQUALIFIER: geneticsAUTHOR: A Sarasin AAUTHOR: C Robert-Knebelmann CAUTHOR: A Stary AAFFILIATION: Laboratoire de Génétique Moléculaire, Institut de Recherches Scientifiques sur le Cancer, Villejuif, France.PUBTYPE: Journal ArticlePUBTYPE: ReviewJOURNALTITLE: Pathologie-biologie. COUNTRY: FRANCETITLE: [DNA repair and related diseases]PUBDATE: 19920201
DNA-repair is a complex enzymatic process which enables all living cells to withstand the deleterious and mutagenic effects of most genotoxic agents. Defective DNA-repair is caused by mutations involving genes which encode the enzymes responsible for recognition and excision of DNA lesions. Some of these genes have been identified in humans. Several severe human diseases are caused by defective DNA repair affecting the entire genome (e.g. xeroderma pigmentosum and trichotiodystrophy) or only actively transcribed genes (Cockayne's syndrome). Some of these conditions are associated with extremely high rate of cancer.

4. DOCID:19866 SCORE: 0.00345671714859467DOCNO: 8471552OWNER: NLMSTATUS: MEDLINEQUALIFIER: therapyAUTHOR: E Tomiak EAUTHOR: M Piccart MAFFILIATION: Institut Jules Bordet, Brussels, Belgium.PUBTYPE: Journal ArticlePUBTYPE: ReviewJOURNALTITLE: Annals of oncology : official journal of the European Society for Medical Oncology / ESMO. COUNTRY: NETHERLANDSTITLE: Routine follow-up of patients after primary therapy for early breast cancer: changing concepts and challenges for the future.PUBDATE: 19930301
In an era of increasing financial constraints, physicians are being forced to critically re-evaluate various clinical practices that have not been shown to be cost-effective or associated with definitive patient benefit. Routine follow-up programs following primary therapy for early-stage breast cancer vary widely from centre to centre, and although the subject of numerous retrospective analyses, they have not been prospectively evaluated to date. This review paper presents arguments for changing the emphasis of follow-up visits and stresses the need for prospective clinical and cost-benefit evaluations of current follow-up practices.

5. DOCID:18467 SCORE: 0.00299440520146396DOCNO: 8275848OWNER: NLMSTATUS: MEDLINEQUALIFIER: surgeryQUALIFIER: surgeryQUALIFIER: surgeryAUTHOR: L Y Wu LYAFFILIATION: Fourth People's Hospital, Qingdao.PUBTYPE: Journal ArticleJOURNALTITLE: Zhonghua wai ke za zhi [Chinese journal of surgery]. COUNTRY: CHINATITLE: [A new technique for colon-anal anastomosis by intra-anal circular ligation]PUBDATE: 19930401
Using self-made supporting tube, we performed colon-anal anastomosis in 48 radical resections of low rectal carcinoma, to save the anal canal and sphincter. The anastomoses were completed without suturing and the results were satisfactory. Postoperative follow up revealed that the bowel movement and sphincteric function were all satisfactory. The rate of anastomotic leak was about 4% and there was no operative mortality. This new technic is simple, safe and easy to perform, and is considered to be a promising procedure for colon-anal anastomosis after resection of low rectal cancer.

6. DOCID:18382 SCORE: 0.00293388028377216DOCNO: 2332177OWNER: NLMSTATUS: MEDLINEQUALIFIER: diagnosisQUALIFIER: diagnosisAUTHOR: S J Brozena SJAUTHOR: G Waterman GAUTHOR: N A Fenske NAAFFILIATION: Department of Internal Medicine, University of South Florida College of Medicine.PUBTYPE: Journal ArticleJOURNALTITLE: Geriatrics. COUNTRY: UNITED STATESTITLE: Pigmented skin lesions in the elderly: considerations in the differential diagnosis.PUBDATE: 19900501
Malignant melanoma affects all age groups, but its highest age-specific incidence is in the elderly. Early diagnosis depends on the ability to identify potential precursor lesions and subtle changes in melanocytic nevi indicative of malignant degeneration. Familiarity with the clinical appearance of the common benign pigmented lesions is essential to minimize unnecessary biopsy procedures. Certain clues aid the differential diagnosis and enhance early recognition, which is presently the most effective means of reducing both the morbidity and mortality from this most ominous of skin cancers.

7. DOCID:17420 SCORE: 0.00279065767901833DOCNO: 1736178OWNER: NLMSTATUS: MEDLINEQUALIFIER: physiologyQUALIFIER: psychologyAUTHOR: C A Meyers CAAUTHOR: J L Abbruzzese JLAFFILIATION: Department of Neuro-Oncology, University of Texas M.D. Anderson Cancer Center, Houston 77030.PUBTYPE: Journal ArticleJOURNALTITLE: Neurology. COUNTRY: UNITED STATESTITLE: Cognitive functioning in cancer patients: effect of previous treatment.PUBDATE: 19920201
Neuropsychological analysis of 47 cancer patients with widely metastatic disease and significant previous treatment indicated that 34% had cognitive deficits. Previous treatment with biologic response modifiers was associated with a 53% frequency of cognitive abnormalities, whereas only 18% of patients who were never treated with biologics had such impairments. The possibility that neurobehavioral abnormalities will result from metastatic disease and treatment regimens is an important factor in determining the risks and benefits of therapy.

8. DOCID:18167 SCORE: 0.00277698986596971DOCNO: 1712993OWNER: NLMSTATUS: MEDLINEDESCRIPTOR: Infusion PumpsQUALIFIER: instrumentationQUALIFIER: administration & dosageQUALIFIER: drug therapyQUALIFIER: instrumentationAUTHOR: M U Linnemann MUAUTHOR: T Jonsson TAFFILIATION: Københavns Amts Sygehus i Herlev, anaestesi- og intensivafdeling.PUBTYPE: Journal ArticleJOURNALTITLE: Ugeskrift for laeger.COUNTRY: DENMARKTITLE: [Continuous epidural treatment of cancer pain using a portable infusion pump]PUBDATE: 19910601
Treatment of cancer pain with opioids through an epidural catheter, with a portable infuser has been recorded in 20 patients retrospective. In general there was a good acceptance of the treatment, which often could liberate the patients from close contacts to the pain clinic. There were not recorded adverse effects in relation to the infuser treatment. One patient had systemic adverse effects because of a very high daily opioid dose. The Pharmacia Deltec infuser employed has proven very secure and easy to handle.

9. DOCID:17512 SCORE: 0.00262012789826184DOCNO: 8278712OWNER: NLMSTATUS: MEDLINEDESCRIPTOR: Digestive System NeoplasmsDESCRIPTOR: Pregnancy Complications, NeoplasticAUTHOR: C de la Fontaine CAUTHOR: P Frileux PAUTHOR: A Berger AAUTHOR: P H Cugnenc PHAFFILIATION: Service de Chirurgie digestive, Hôpital Laënnec, Paris.PUBTYPE: Journal ArticlePUBTYPE: ReviewJOURNALTITLE: Revue française de gynécologie et d'obstétrique. COUNTRY: FRANCETITLE: [Digestive system cancers and pregnancy]PUBDATE: 19931101
Digestive tract cancers are infrequent during pregnancy. Prognosis is usually dismal both because diagnosis is delayed as a result of symptoms being ascribed to the pregnancy and because saving both the mother and fetus is difficult. A review of the relevant literature, focused on colorectal and gastric cancers which are the most common forms, emphasizes the need for early diagnosis and for adjusting treatment to gestational age at diagnosis.

11. DOCID:16696 SCORE: 0.00247093488112094DOCNO: 2163983OWNER: NLMSTATUS: MEDLINEQUALIFIER: diagnosisAUTHOR: C B Wallach CBAUTHOR: R C Kurtz RCAFFILIATION: Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York.PUBTYPE: Journal ArticlePUBTYPE: ReviewJOURNALTITLE: Gastroenterology clinics of North America. COUNTRY: UNITED STATESTITLE: Gastrointestinal cancer in the elderly.PUBDATE: 19900601
The older patient population, aged 70 years and greater, represent a large proportion of patients diagnosed with gastrointestinal malignancies. Surgery remains the mainstay of treatment for these malignancy sites. Chronologic age alone should not determine the extent of surgical or medical management. The authors describe those aspects of gastrointestinal cancer detection and therapy that are unique to the aging population.

12. DOCID:17429 SCORE: 0.00241783389034717DOCNO: 1890060OWNER: NLMSTATUS: MEDLINEQUALIFIER: therapeutic useQUALIFIER: drug therapyAUTHOR: M al-Sarraf MAUTHOR: J A Kish JAAUTHOR: J F Ensley JFAFFILIATION: Department of Medicine, Wayne State University, Detroit, Michigan.PUBTYPE: Journal ArticlePUBTYPE: ReviewJOURNALTITLE: Hematology/oncology clinics of North America. COUNTRY: ENGLANDTITLE: The Wayne State University experience with adjuvant chemotherapy of head and neck cancer.PUBDATE: 19910801
Because of the poor results of standard therapy in patients with locally advanced head and neck cancers, chemotherapy is increasingly used to improve the outcome of these patients. In resectable disease, chemotherapy is being investigated before definitive treatments, after surgery, concurrent with postoperative radiotherapy, after radiotherapy, and for possible laryngeal salvage. In unresectable cancers, chemotherapy before, concurrent with, and following radiotherapy is being investigated.

13. DOCID:18533 SCORE: 0.00241320857578956DOCNO: 8468270OWNER: NLMSTATUS: MEDLINEDESCRIPTOR: MutagenesisQUALIFIER: therapyAUTHOR: K T Kelsey KTAUTHOR: M Caggana-Aviles MAUTHOR: P Mauch PAUTHOR: C N Coleman CNAUTHOR: L N Shulman LNAUTHOR: H L Liber HLAFFILIATION: Department of Cancer Biology, Harvard School of Public Health, Boston, Massachusetts.PUBTYPE: Journal ArticleJOURNALTITLE: Hematology/oncology clinics of North America.COUNTRY: ENGLANDTITLE: Mutagenesis after therapy for Hodgkin's disease.PUBDATE: 19930401
Therapy for Hodgkin's disease has been associated with a significant increase in risk for second cancers. To begin an investigation of the association of therapy-induced genetic damage with this risk, somatic mutations at the hypoxanthine phosphoribosyltransferase locus were measured in lymphocytes from patients previously treated for Hodgkin's disease. The results demonstrate that a subset of patients have persistently elevated mutation frequencies, perhaps suggesting that these individuals are among those at significant risk of second cancer development.

14. DOCID:18488 SCORE: 0.00239447010051948DOCNO: 1435711OWNER: NLMSTATUS: MEDLINEQUALIFIER: pathologyQUALIFIER: pathologyQUALIFIER: pathologyAUTHOR: M Hashimoto MAUTHOR: M Takano MAUTHOR: T Fujiyoshi TAUTHOR: K Takagi KAUTHOR: M Kawano MAFFILIATION: Coloproctology Center, Takano Hospital, Kumamoto, Japan.PUBTYPE: Case ReportsPUBTYPE: Journal ArticleJOURNALTITLE: Nippon Geka Gakkai zasshi. COUNTRY: JAPANTITLE: [A case of minimal-sized adenocarcinoma in a fistula-in-ano]PUBDATE: 19920801
The patient was 47 year-old man with a simple intermuscular fistula-in-ano. Fistulectomy revealed that there was a small mucinous adenocarcinoma. The tumor was small and localized in the wall of the fistula and the muscular invasion was not recognized. The mucin contained a little O-acylated sainomucin, and the origin of the tumor was considered as anal gland cell. This case appears as one evidence that the cancer in fistula-in-ano originates from the anal gland cell in the fistula.