Wyatt Technology Corporation, the world leader in absolute macromolecular characterization instrumentation and software, will be presenting on innovative light scattering techniques at WCBP 2014, Washington, DC, January 28 – 30.

The 18th Symposium on the Interface of Regulatory and Analytical Sciences for Biotechnology Health Products provides a forum for discussing the latest bioanalytical methods and their practical application to biotechnology, pharmaceuticals and other health-related products.

Dr. Daniel Some, Director of Marketing and Principal Scientist at Wyatt Technology will be hosting a seminar entitled “Molar mass, size and interactions: light scattering tools for essential biophysical characterization.” From aggregates to conjugates, light scattering detectors combine with a variety of sample delivery systems to provide a comprehensive suite of biophysical characterization tools. This talk will include a detailed overview and examples of the tasks relevant to well-characterized biopharmaceuticals that may be accomplished with these tools.

The characterization of therapeutic protein formulations is essential for the development of novel biopharmaceuticals. In particular, solution viscosity and colloidal stability may be adversely impacted by attractive self-interactions among protein molecules. Focusing on high protein concentrations, a poster authored by Dr. Sophia Kenrick, Applications Scientist at Wyatt Technology and Dr. Dan Some will highlight a study that quantified affinity and stoichiometry of self-association for several monoclonal antibody formulations using composition-gradient multi-angle light scattering (CG-MALS), automated by the Wyatt Calypso®. Entitled “Quantifying the Effect of Self-Interactions on Solution Viscosity at High Protein Concentrations” the poster demonstrates how antibodies exhibiting only repulsive interactions resulted in formulations with lower viscosity than those exhibiting attractive interactions.

Geofrey Wyatt, President of Wyatt Technology, comments, “WCBP is an excellent symposium where state-of-the-art innovations as well as conventional technologies addressing research and routine testing applications are highlighted. We are excited to be highlighting our light scattering techniques and instrumental advances that can be used for product characterization, process development, in-process analysis and validation of release and stability testing.”

With a long history of excellence in scientific instrumentation, Wyatt Technology is the recognized leader in innovative, quality light scattering instruments and software for determining the solution properties of macromolecules and nanoparticles in solution:

Molar mass

Size

Charge or zeta potential

Biomolecular interactions

Conformation and composition

Wyatt provides solutions for in-line multi-angle static light scattering (SEC-MALS), field-flow fractionation (FFF-MALS), composition gradients (CG-MALS), high-throughput and traditional dynamic light scattering (DLS), electrophoretic mobility (ELS), differential refractometry and differential viscosity. Through a staff comprising 20% Ph.D. scientists and many more dedicated and experienced support personnel, Wyatt's aim is to delight the customer with the best training, customer support and service available in the industry.

Comments

Tell Us What You Think

Do you have a review, update or anything you would like to add to this news story?