2. Know your tolerance

Use less drug then before if: you are also taking certain prescription medications (they can impact the body’s ability to process the drugs) and/or you are using after a period of time of non-use (detox, abstinence, hospitalization, jail or new use).

3. Don't mix drugs

Do not mix drugs and alcohol. If you do, use the drugs first before the alcohol. Mixing opioids with downers or opioids with uppers puts you at higher risk of overdose; try to take one thing at a time.

4. Know the quality of the drugs

The street quality of substances is unpredictable, do testers, go slow, and try to use a consistent reliable dealer.

5. Know your health and body

If you have hepatitis or liver problems, breathing problems, lack of sleep, dehydration, or infections, they can put you at higher risk for overdose. Ensure to eat, drink water, sleep and see a doctor for infections or health concerns.

6. Learn more about naloxone

Naloxone is a medication that can reverse an overdose. Naloxone is available free to people who use drugs and can be purchased at pharmacies for non-drug users. Learn more about where you can get naloxone.