My intention was to create a work of art which would transcend the visible, which cannot be perceived except in stages, with the understanding that it is a partial revelation and not the perpetuation of the existing. My aim is to show what can be seen within the limits of possibility which exists in the midst of coming into being.[6]

Agam's work is usually abstract, kinetic art, with movement, viewer participation and frequent use of light and sound. His works are placed in many public places. His best known pieces include "Double Metamorphosis III" (1965), "Visual Music Orchestration" (1989) and fountains at the La Défense district in Paris (1975) and the "Fire and Water Fountain" in the Dizengoff Square in Tel Aviv (1986). He is also known for a type of print known as an Agamograph, which uses lenticular printing to present radically different images, depending on the angle from which it is viewed. The lenticular technique was executed in large scale in the 30 ft (9.1 m) square "Complex Vision" (1969) which adorns the facade of the Callahan Eye Foundation Hospital in Birmingham, Alabama.[7]

In 2009, at age 81, Agam created a monument for the World Games in Kaohsiung, Taiwan titled "Peaceful Communication with the World". It consists of nine 10m high hexagon pillars positioned in diamond or square formation. The sides of the pillars are painted in different patterns and hues, totaling more than 180 shades. One side of each pillar is also lined to segment the structure into sections, so that children's perception of the pillar will change as they grow, because they will see a different pillar at a different height.[10]

One of Agam's more notable creations is the HanukkahMenorah at the corner of Fifth Avenue and 59th Street in New York City, sponsored by the Lubavitch Youth Organization. The 32-foot-high, gold colored, 4,000 pound steel structure is recognized by the Guinness Book of World Records as the World's Largest Hanukkah Menorah. It uses real oil lamps, which are lighted every year during Hanukkah with the aid of cherry-picking machines.[11]

In May 2014, Agam's piece "Faith- Visual Pray" was presented to Pope Francis by El Al Israel Airlines' president, David Maimon. The piece included significant symbols of both Jewish and Christian faiths.[12]

Agam is the highest-selling Israeli artist. In a Sotheby's New York auction in November 2009, when his "4 Themes Contrepoint" was sold for $326,500, he said: "This does not amaze me … my prices will go up, in keeping with the history I made in the art world." A year later, his "Growth", an outsize kinetic painting done in oil on a wood panel, which was shown at the 1980 retrospective at the Guggenheim Museum, estimated at $150,000 to $250,000, sold for the record-breaking sum of $698,000.[13]