PharmacokineticsActions of body on the drug  Non-specific, general processes • Absorption from site of administration • Distribution to the site of action • Metabolism • Excretion • Onset of action • Duration of effect • Accumulation • Drug interactions • Inter- and intra-patient differences



Study of biochemical and physiological effects of drugs and their mechanism of action

 Describes the actions of a drug  Includes the measurement of response to drugs and how response relates to drug dose or concentration

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Most drugs must bind to a receptor to bring about an effect

Therapeutic


Toxic

Drug binding is only the 1st step in a complex sequence of events

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Lecture 1 Lecture 2

› Drug Receptors

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› Drug-Receptor Interaction

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Lecture 3

› Dose-Response Curve

What are Receptors?  Classification of receptors  Not all drugs have receptors 

Understand what receptors & their characteristics are’  Name and describe the classes of receptors.  Give an example of each class of receptors.  Understand that not all drugs require a receptor to work. Give examples of such drugs. 



Are usually proteins or part of a protein that have a distinct region to which drugs bind → 1.

produces a change that:
Directly induces a measurable response

2. Triggers a transduction chain that in turn produces a measurable response

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Usually made up of at least 2 domains
 Ligand –binding domain  Effector/catalyic domain



Can be located at:

 Cell surface  Within the cytoplasm or  Inside the nucleus



Receptors

 determine the quantitative relations between dose/concentration of drug and pharmacologic effects  are responsible for selectivity of drug action

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