The role of lipid peroxidation in reduced red cell deformability has been examined after thermal injury of rats (full skin thickness over 15-20 per cent of total body surface). An increased concentration of erythrocyte malonyldialdehyde (MDA) and blood thiobarbituric acid (TBA) reactive product levels during the first 3 days after thermal trauma was… (More)

The effect of FC-43 perfluorocarbon emulsion and alpha-tocopherol on lipid peroxidative damage and deformability of erythrocytes was evaluated in rats (full skin thickness burns over 15-20% of total body surface) at third hour after burns. The animals were divided into five groups: (1) non-burnt non-treated (controls); (2) burnt non-treated; (3) burnt but… (More)

Experimental thermal trauma of IIIa-IIIb degree was induced on an area of 15-20% in male Wistar rats weighing 200-250 g. The changes in the content of the products of free-radical oxidation (FRO) - conjugated dienes and thiobarbituric acid (TBA) products in the blood, haemodialysis, the activity of superoxide dismutase (SOD) and of G-6-PHD-ase in the… (More)

Increased concentration of the products of red-cell free-radical oxidation (FRO), i.e. of malondialdehyde (MDA) and of Schiff bases in red cells and of their hemolysis was recorded in the acute period of experimental thermic injury. Alpha-tocopherol applied after thermic injury suppressed FRO and restricted red cell hemolysis. A strong positive correlation… (More)

The anticholinesterase properties of nivalin, its low toxicity and penetration through the blood-liquor barrier make it an adequate agent for the treatment of acute atropine intoxications. Regardless of all that it is not mentioned in our toxicological literature and is not used in the clinical practice. iNivalin in doses 0.25-0.5 mg/100 g body mass was… (More)

Alterations in the erythrocyte rheology and the contents of activated free radical oxidation products (conjugated dienes, products of thiobarbituric acid and Schiff bases) in the acute phase of experimental thermic injury of the skin were studied. Erythrocyte flexibility reduction and erythrocyte aggregation increase correlated with elevated amounts of free… (More)

After the burn, the authors immediately applied the albuminous hydrolysate Hydropot, a propolis-urea ointment and Trypsin compresses (3,500 E) to the burned area and its vicinity, and repeated this procedure for several days. Samples for histological examination were taken after the animals' decapitation every 2 hrs. and on the 3rd, 5th and 14th post-injury… (More)

Reduced erythrocyte osmotic resistance against the background of elevated blood level of TBA-reactive products was recorded in experimental thermic injury (of IIIa-IIIb degree, involving 15-20 per cent of the body surface). Under the influence of alpha-tocopherol, parallel with the restriction of free-radical oxidation (FRO) activity, there was a rise in… (More)