proposed as a NET liquid biopsy ( 21 ). The NETest, as opposed to CgA or other monoanalyte peptides/hormones, is a multianalyte molecular signature representing biological information pertinent to the clinical neuroendocrine disease course. It has numerous

. Given the limited accuracy of the currently available biomarkers and the known limitations of single analyte measurements (20, 21) , we developed a blood-based multianalyte NET-specific gene transcript analysis – the NETest. This is a robust

effort has been expended in the development of novel approaches to rectify these shortcomings, such as PCR-based multi-analyte methods of assessing disease activity ( 19 ), analysis of miRNAs ( 5 ), metabolomic profiling ( 20 ) and prognostic nomograms