to the healing of any wound. Even glucose deprivation can cause the induction of HIF.

Prostaglandins, made from polyunsaturated fatty acids released by stimulation, can

cause HIF to increase, but HIF also causes prostaglandins to increase. Lactic acid

increases the expression of HIF, while HIF causes cells to shift metabolically to depend

on converting glucose to lactic acid, that is, to adopt the "cancer metabolism." HIF is

recognized as a fundamental problem in "cancer therapy," since HIF allows the cancer

to resist the treatment, but the treatment increases HIF.

Radiation, chemotherapy, and surgery all activate these processes of cell replacement,

and unless something has changed to improve the organism's recuperative ability, it

isn't clear why the cells which replace the missing part should be more able to

satisfactorily complete the recovery process than the original cells were. Even the

amount of radiation in a single dental x-ray is enough to activate the excitatory-inflammatory

processes, and a "therapeutic" x-ray to any part of the body excites similar, but much greater, processes throughout the body. But the ideology of "the cancer cell," and the Gompertz Growth Law, guide the practice of cancer treatment.

Many years ago, Harry Rubin was impressed by hearing from a pathologist that he had

been able to find diagnosable cancer somewhere in the body of every person over the

age of 50 that he had autopsied. If everyone has cancer by the age of 50, that means

that cancer is harmless for most people, and that small cancers might frequently

appear, and be spontaneously removed as part of the body's regular house-cleaning.

One of the reasons that spontaneous regression of tumors seems so rare is

undoubtedly that most tumors are quickly cut out by surgeons.

Preventing injury should be a basic consideration, but the medical slogan, "first do no

harm," just doesn't apply to the cancer treatment industry, and this results from the

doctrine of "the cancer cell," which is something to be destroyed or kept from

multiplying. In the process of diagnosing a cancer, and during the course of treating it,

the patient is usually subjected to multiple x-ray examinations, sometimes given

radioactive drugs that supposedly concentrate in hidden tumors to emit positrons, and

often has toxic contrast agents injected even for MRI examinations. These procedures,

even before the destructive "therapies" begin, are adding to the body's inflammatory

burden, interfering with the body's ability to complete a healing process. Decisions

about pain control usually disregard the effects of the drugs on tumor growth and

general vitality--for example, the opiates stimulate histamine release, which increases

inflammation and tumor growth.

In 1927, Bernstein and Elias found that rats eating a fat free diet had almost no

spontaneous cancer, and many studies since then in animals and people have shown a

close association between polyunsaturated fatty acids and cancer. The polyunsaturated

fatty acids in themselves, and their breakdown products, are excitatory and destabilizing

to normal cells, but by modifying the sensitivity and energy production of cells, they limit

cells' ability to respond to stimulation and destabilizing influences. Although they aren't

essential for wound healing (Porras-Reyes, et al., 1992), they and their metabolites, the

prostaglandins, are very conspicuous in wounds and tumors, and their proportion

generally increases with aging. The prostaglandins are involved in several vicious

cycles, including that with HIF mentioned above. This makes the PUFA and

prostaglandins important to consider in relation to optimizing wound healing, and

decreasing cancerization. Aspirin's protective and therapeutic effects in cancer are

starting to be recognized, but there are several other things that can synergize with

aspirin to reduce the circulation of free fatty acids and their conversion to

substances and some anesthetics such as xenon (Weigt, et al., 2009) are safe. Inhibitory substances related to GABA are being investigated for their ability to stop tumor growth. Simply stopping excessive excitation tends to restore the dominance of oxidative respiration over glycolysis.

To restore the supply of oxygen, sugar, and nutrients, swelling must be stopped.