..Because the inherited variant in 11q23 has been associated with risk of lower grade glioma and not with glioblastomas, we hypothesized that this variant increases susceptibility to IDH-mutated gliomas, but not to IDH-wild-type gliomas...

Intracranial hemangiopericytoma: clinical experience and treatment considerations in a modern series of 40 adult patients

Martin J RutkowskiDepartment of Neurological Surgery, University of California at San Francisco, San Francisco, California, USACancer 118:1628-36. 2012

..Intracranial hemangiopericytoma (HPC) is a malignant meningothelial tumor. Because of its rarity, few guidelines exist for optimal management...

Role of extent of resection in the long-term outcome of low-grade hemispheric gliomas

..This multimodality approach also appears to outperform GKS in extending time to second recurrence. Accordingly, when safe and feasible, surgical resection of recurrent HPC with adjuvant EBRT should be the first steps in management...

..Vertebroplasty is useful for improving pain symptoms, especially when vertebral body compression fracture has occurred in patients without neurological deficit, but is less effective in providing long-term pain relief...

The superiority of conservative resection and adjuvant radiation for craniopharyngiomas

..In the current study, the authors present a modern series of confirmed PGS cases treated in the era of magnetic resonance imaging (MRI), after the accepted glioblastoma management of resection, radiation, and temozolomide...

Surgical resection and adjuvant radiotherapy for a large pineal hemangiopericytoma

..We have found integration of SNP annotation in the context of pathway information and functional prediction scores to be a powerful approach to the analysis and interpretation of SNP-disease association data...

Kyle M Walsh1 Division of Neuroepidemiology, Department of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA 2 Program in Cancer Genetics, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California, USANat Genet 46:731-5. 2014

..No other risk loci for glioma were associated with LTL. The identification of risk alleles for glioma near TERC and TERT that also associate with telomere length implicates telomerase in gliomagenesis. ..

Pathology of spinal ependymomas: an institutional experience over 25 years in 134 patients

Phiroz E TaraporeDepartment of Neurosurgery, University of California, San Francisco, San Francisco, California Department of Pathology, University of California, San Francisco, San Francisco, CaliforniaNeurosurgery 73:247-55; discussion 255. 2013

..Ependymomas constitute approximately 40% of primary intraspinal tumors. Current World Health Organization (WHO) grading may not correlate with observed progression-free survival (PFS)...

..Therefore, in one of the most challenging differential diagnoses, IDH1 positivity could provide strong support for glioblastoma with oligodendroglial component, while essentially excluding small cell glioblastoma...

Transmantle sign in focal cortical dysplasia: a unique radiological entity with excellent prognosis for seizure control

..Two of nine patients treated for AT/RT at our institution with high dose chemotherapy and autologous bone marrow transplant are long-term survivors, suggesting that a subset of patients can be cured with this approach...

Clinicopathological characteristics of adamantinomatous and papillary craniopharyngiomas: University of California, San Francisco experience 1985-2005

..Neither IMT nor IP cases demonstrated HHV-8 expression. We suggest that IMT in the CNS is distinct from the nonneoplastic IP, and distinguishing IMT from nonneoplastic lesions should enable better decisions for patient management...

..The authors describe their experience and review the literature, emphasizing that a dermoid cyst may have unusual radiographic characteristics indicative of hemorrhage and may contain areas of hemorrhage on histological examination...

..This pattern of genetic changes only partially overlaps with the genomic alterations reported in pituitary adenomas. In summary, our data suggest that pituicytomas are a unique subset of tumors of the sellar region...

..Despite less than complete inclusion of genes and SNPs relevant to glioma and a small sample size, RF analysis identified one important biological pathway and several SNPs potentially associated with the development of glioblastoma...

..Improving our understanding of the molecular biology, genetics, and oncogenic pathways associated with this tumor will allow for the development of targeted therapies and improved outcomes for patients with this disease...

Sarcoma arising as a distinct nodule within glioblastoma: a morphological and molecular perspective on gliosarcoma

..Clinical and pathologic characteristics distinct from GBM suggest that they may warrant specific treatment, separate from conventional GBM therapy...

Radiobiology of vestibular schwannomas: mechanisms of radioresistance and potential targets for therapeutic sensitization

Andrea H YeungDepartments of Otolaryngology Head and Neck Surgery, University of California at San Francisco, San Francisco, California, USANeurosurg Focus 27:E2. 2009

..An improved understanding of the radiobiological behavior of VS may help guide appropriate patient selection for SRS and potentially aid in the design of novel therapies to treat radioresistant tumors...

..When used in conjunction with clinical and radiologic data, histopathologic features can distinguish among this wide range of possibilities to provide the correct diagnosis for optimal patient management...

Mark A WatsonDepartment of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USABrain Pathol 14:297-303. 2004

..We conclude that distinct molecular classes of MPNST exist and that the ability to stratify these tumors based on unique and biologically relevant gene expression profiles may be important for future targeted therapeutics...

Polilactofate microspheres for Paclitaxel delivery to central nervous system malignancies

..It is also unclear whether the desmoplastic noninfantile ganglioglioma has characteristics similar to classical ganglioglioma. This rare case highlights the remarkable versatility of glioneuronal tumors in children...

Pilocytic and pilomyxoid hypothalamic/chiasmatic astrocytomas

Ricardo J KomotarDepartment of Neurosurgery, Columbia University College of Physicians and Surgeons, New York, New York, USANeurosurgery 54:72-9; discussion 79-80. 2004

..This article describes the clinicopathological features of these unusual neoplasms, which are currently known as pilomyxoid astrocytomas (PMAs), to better differentiate them from typical PAs...

..To increase awareness of PMA within the neurosurgical community, the authors review the diagnostic criteria, prognostic implications, and current management of this recently described pediatric low-grade astrocytoma...

..All PMAs reported to date involved the hypothalamic/chiasmatic region. Since these original reports, we have encountered three tumors in the spinal cord with histological features identical to those of PMA...

Growth and regression of arteriovenous malformations in a patient with hereditary hemorrhagic telangiectasia. Case report

..Histopathological features of the surgical specimen were examined. Active angiogenesis, as indicated by increased endothelial proliferation, might be a part of the underlying pathophysiology of the growth and regression of AVMs...