Test Code SGSU
Synthetic Glucocorticoid Screen, Urine

Reporting Name

Useful For

Confirming the presence of the listed synthetic glucocorticoids
(see Interpretation)

Confirming the cause of secondary adrenal insufficiency

This assay does not detect fluticasone propionate.

Performing Laboratory

Mayo Medical Laboratories in Rochester

Specimen Type

Urine

Specimen Required

Container/Tube: Plastic, 10-mL urine tube (Supply
T068)

Specimen Volume: 5 mL

Collection Instructions:

1. Collect a random urine specimen.

2. No preservative.

Specimen Minimum Volume

0.6 mL

Specimen Stability Information

Specimen Type

Temperature

Time

Urine

Frozen (preferred)

14 days

Ambient

7 days

Refrigerated

7 days

Reference Values

Negative

Cutoff concentrations

Beclomethasone dipropionate: 0.10 mcg/dL

Betamethasone: 0.10 mcg/dL

Budesonide: 0.10 mcg/dL

Dexamethasone: 0.10 mcg/dL

Fludrocortisone: 0.10 mcg/dL

Flunisolide: 0.10 mcg/dL

Fluorometholone: 0.10 mcg/dL

Megestrol acetate: 0.10 mcg/dL

Methylprednisolone: 0.10 mcg/dL

Prednisolone: 0.10 mcg/dL

Prednisone: 0.10 mcg/dL

Triamcinolone 0.30 mcg/dL

Triamcinolone acetonide: 0.10 mcg/dL

Values for normal patients not taking these synthetic
glucocorticoids should be less than the cutoff concentration
(detection limit).

Day(s) and Time(s) Performed

Wednesday, 8 a.m.

Test Classification

This test was developed and its performance characteristics
determined by Mayo Clinic in a manner consistent with CLIA
requirements. This test has not been cleared or approved by the
U.S. Food and Drug Administration.

CPT Code Information

82544

LOINC Code Information

Result ID

Reporting Name

LOINC Code

23561

Beclomethasone Dipropionate

46945-2

23562

Betamethasone

46946-0

23563

Budesonide

46947-8

23564

Dexamethasone

46948-6

23565

Fludrocortisone

46949-4

23566

Flunisolide

46950-2

23567

Fluorometholone

46951-0

23568

Fluticasone Propionate

46952-8

23569

Megestrol Acetate

46953-6

23570

Methylprednisolone

46954-4

23571

Prednisolone

46955-1

23572

Prednisone

46956-9

23573

Triamcinolone

46957-7

23574

Triamcinolone Acetonide

46958-5

Clinical Information

Synthetic glucocorticoids are widely used and have important
clinical utility both as anti-inflammatory and immunosuppressive
agents. The medical use of these agents, as well as their
surreptitious use, can sometimes lead to a confusing clinical
presentation. Patients exposed to these steroids may present with
clinical features of Cushing syndrome, but with suppressed cortisol
levels and evidence of hypothalamus-pituitary-adrenal axis
suppression.

The presence of synthetic glucocorticoids in urine indicates
current or recent use of these compounds. Since several of these
compounds exceed the potency of endogenous cortisol by 1 or more
orders of magnitude, even trace levels may be associated with
Cushingoid features.