Objective: The purpose of this study is to investigate the level of mental health among the students in Kashan Medical University, and its relationship with their demographic characteristics. Method: In this study 253 students (185 female, 68 male) were selected as subjects and responded to the 28 items General Health Questionnaire (GHQ-28). Those students who obtained a higher score from the cutoff point (22 for men, and 21 for women), were chosen for clinical interview. Findings: The results indicated that 28.4% of the students suffered from one of the four following disorders: major depression (8.7%), adjustment disorder, (6.7%), dysthymia (5.9%), generalized anxiety disorder (4.7%), and double depression (2.4%). The rate of disorders in non-local students was more than local students. Also the rate of disorder was higher in those with lower interest in study subject compared with those with higher interest in their study discipline. Among the single individuals was 29.5%, and in married ones was 12.4%. Moreover 52.6% of students with disorder, had a background of psychiatric disorder.