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The contribution of epigenetics to SLE phenotype and outcome

2/1/15 - 1/31/18

Investigator: Lindsey A. Criswell, MD, MPH

Sponsor: Alliance for Lupus Research

Location(s): United States

Description

The overall goal for this project is to define the mechanisms through which differences in epigenetic alterations influence the pattern and severity of symptoms in individual lupus patients and certain types of lupus patients. Further, it is known that several medications currently approved to treat other illnesses successfully target epigenetic mechanisms; the study will explore whether some of these medications might provide benefit to lupus patients.