One of the objectives of TIDE-BC is development of tests by a relatively new technology called tandem mass spectrometry (TMS). With TMS, a large number of metabolites can be measured simultaneously to screen for treatable metabolic disorders.

Supported by TIDE, work is underway to develop a comprehensive amino acid panel for the diagnosis and monitoring of a variety of treatable amino acid and urea cycle disorders. Test development includes oxysterol analysis to screen for Niemann Pick type C, for which there is a new treatment. To increase capacity further for new test development, a fundraising effort was launched by Dr. Vallance and Dr. Sinclair (BGL Lab Scientists) to acquire an additional TMS instrument. Over $90,000 was raised from personal donations and industry sponsors, as well as a contribution from TIDE-BC, with the difference generously provided by the Provincial Health Services Agency. The TMS instrument is dedicated to the memory of Judie Nelson who was responsible for years of TMS method development in the Dept of Pathology and Laboratory Medicine.

Our evidence-based research in 2014 identified 89 rare inborn errors of metabolism, with ID as a major feature, which are potentially treatable. In May 2016 our TIDEX exome study adds to this list with the discovery of new diseases amenable to therapy.

What is TIDE BC?

Tide BC is a new care & research initiative with a focus on prevention and treatment of Intellectual disability (ID). We have shown that the ID seen in some children is due to treatable genetic conditions known as inborn errors of metabolism. Many of these can be treated with diet or drugs.

Our Goal

By improving diagnosis, treatment and care and by using the best of modern day technologies, TIDE BC aims to improve health outcomes of all those affected.

A new Care & Research Initiative

with a focus on prevention & treatment of Intellectual Disability

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Worldwide 2% - 3% of the population suffer ID

That is 800 - 1200 newborns in British Columbia each year...

Time = Brain

Timely diagnosis improves the outcome of children with ID

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