The Special
Committee of InfuSystem Holdings, Inc. Board of Directors has received and reviewed your letter of July 17, 2013 indicating your interest to acquire the Company for between $1.85 and $2.00 per share in cash. The Special Committee recognizes
that this is an increase in value from earlier informal statements and discussions.

The Special Committee believes that the management team
under the leadership of the Companys new CEO, Eric Steen, will meet the challenges presented by CMS competitive bidding and will develop new opportunities for growth creating value for shareholders.

The Special Committee continues to believe that the value of the Company is above your proposed offer range of $1.85 to $2.00 per share. However we are
prepared to agree to a reasonable period of exclusivity for due diligence and dialogue to better understand and address your concerns regarding future risks and to help you to potentially increase the value of your proposal. In addition the Special
Committee requests confirmation of your stated financing sources to support your proposal.

All requests for information, and access to
management, will be required to be processed by and through the Companys investment banking firm, Houlihan Lokey.