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The most likely cause for
this problem is that your firewall does not allow MSN Messenger to
access the Internet. This happens often if you install a new version of
Messenger. Make sure MSN Messenger is allowed access in your firewall
rules.

This error might also be occuring because there is a proxy
server enabled in MSN Messenger while you do not use one. To remove the
proxy settings, click the "Tools" menu and then "Options..." at your MSN
Messenger main window. Then in the options screen click "Connection" in
the list to the left. Next, click the "Advanced Settings..." button.
You can try and uncheck all checkboxes in this screen except the one
labeled "TCP" to let MSN Messenger connect through a direct connection.
If that does not work you can restore the settings again by checking the
boxes you unchecked before.

If you did not try to enter the wrong password many times, someone must be trying to hack your account, if it was you, it may have been hacked and your details changed.
Check here for support http://help.uk.msn.com/

The Solutions to MSN Error Code 80048820
Internet Explorer - Try removing the tick next to Internet Explorer 'Proxy server' settings, instead, go with the 'Automatically detect settings'. 1) Launch Internet Explorer, click Tools and then click Internet Options. From the Internet Options dialog box, go to the Connections tab. Click LAN Setting. Un check the Use a proxy server for your LAN (These settings will not apply to dial-up or VPN connections) checkbox. Finally positively tick: 'Automatically detect settings'.2) Register softpub.dll.
Click Start (Button), and then click Run, type regsvr32 softpub.dll. Restart MSN Messenger. See also Error code 810003143) If necessary, logon as a local administrator and set the computer's clock to the correct date and time. (Check on the internet if possible.)4) Turn off the firewall temporarily. Check firewall settings such as Norton: "Block access to secure sites". If this cures the problem, make sure that Microsoft's MSN Messenger is allowed full access through your firewall.
NetGear problem, but also with some other routers a) Enter IP address 192.168.0.1 in your browser's address bar.b) Log on with ISP user name and password.c) Enter Admin, passwordd) Navigate to advanced menu, WAN set-upe) Change MTU size to 14005) Try a password of no more than 8 characters.6) If you are using IE 7.0 check the SSL Settings. Internet options advanced (Tab) scroll down to the bottom. Security section. Tick 'Use ssl 2.0'.7) One of the simplest ways of curing MSN error 80048820 is to unplug, or restart your modem. This is particularly effective for cable modems.8) We should have tried this solution before; check that the MSN site is 'up' 'available'. However, even if the site is down, you don't usually get error code 80048820. 8a) As a variation, of checking online, you could try phoning your local Microsoft Support office. Local area numbers available from http://support.microsoft.com.9) Have you just installed any anti-virus software? Did the anti-virus software just make a big update? Try disabling and see if that cures the error.10) A drastic solution is to try uninstalling MSN Messenger version 8.0 or 7.5 and install Microsoft MSN version 7.0.

haha it worked for me i fixed my problem. Try this it might work or might not. Go in to internet explorer and make sure work ofline is not ticked or make sure theres nothing wrong with your internet explorer. Try downloading the latest internet explorer. :D Hope this helps

Step#4
- Turn off the firewall. Check firewall settings such as Norton: "Block
access to secure sites". If this cures the problem, make sure that
Microsoft's MSN Messenger is allowed full access through your firewall.