Semax is a drug produced and prescribed mostly in Russia and Ukraine for a broad range of conditions but predominantly for its purported nootropic, neuroprotective, and neurogenic/neurorestorative properties. It is aheptapeptide, synthetic analog of a fragment of adrenocorticotropic hormone (ACTH), ACTH (4-10), of the following structure: Met-Glu-His-Phe-Pro-Gly-Pro.

Application:

In between the 2 - 3 decades since semax was synthesized and tested, there have been numerous studies on animals and humans to see the benefits of the drug. One of the primary benefits of semax is as a cognitive enhancer. One 2 day study of power plant workers tested semax and memory formation. The 1 mg dose 1 hour prior to the exam showed a drastic increase in correct responses.

The mechanism for improving cognitive function relates to brain chemicals like BDNF and NGF. Semax can increase BDNF and NGF by 8 and 5 times the baseline. Numerous other studies have confirmed the increase in BDNF, which acts as a type of fertilizer for the brain to develop new neurological connections.

Another way semax improves cognitive abilities is through the increase of alpha brain wave states. EEG studies show semax can increase alpha brain waves in patients, but also can prevent negative EEG changes during stressful situations (hyperventilation).

The benefits for alpha brain waves may also help support positive mood enhancement and reducing anxiety. Semax benefits include reducing symptoms of stress and depression. The Journal of Psychophysiology published a study on the sedative effects of semax on those who were suffering from mental illness. Part of these benefits may come from an increase in serotonin turnover, which is traditionally done with SSRIs.

Finally, an interesting but not incredibly well-researched benefit of semax is as for stimulant potentiation. Studies show that semax in combination with stimulants (such as amphetamine) could increase the dopamine release from the drug. One study showed an increase of activity from 182% (just the amphetamine) versus 261% (amphetamine and semax).

How to use:

Chemically speaking, Semax is a neuroactive peptide derived from corticotropin. Corticotropin is a peptide hormone and neurotransmitter that is released by your body during times of stress. When your body is stressed, it needs to think more clearly, which is why corticotropin has a significant effect on your brain.

Semax has the following chemical structure: Pro8-Gly9-Pro10ACTH.

More importantly, Semax has been described as being 1000 times stronger than Piracetam and provides similar benefits to Noopept, Sunifiram, and Unifiram.

Interestingly enough, Russia's love affair with Semax didn't stop when the Soviet Union collapsed. Since 2011, Russia has classified Semax as a "Vital and Essential" drug. The drug is commonly prescribed across Russia - especially when physicians are dealing with conditions that require neuroprotective or neurorestorative effects.

So how does Semax actually work? Semax modulates receptors in the Limbic Reticular complex in your brain. It specifically targets the receptors that handle serotonin, adenosine, histamine, dopamine, and acetylcholine.

Dosage:

For nootropic purposes, a dose 0.25-1mg per day would seem suitable. A single dose is sufficient for the entire day and possibly beyond. Intranasal or Sub-Q administration are the only accepted ways of administering Semax. Do not consume by mouth or sublingually as Semax will be rendered inactive.

Lyophilised Semax will require reconstitution with sterile water before being suitable for injection or intranasal administration.

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