Scientific research should be reproducible, and as such also simulation research. However, the question is – is this really the case? In some application areas of simulation, e.g., cell biology, simulation studies cannot be published without data, models, methods, including computer code being made available for evaluation. With the applications and methodological areas of modeling and simulation, how the problem of reproducibility is assessed and addressed differs. The diversity of answers to this question will be illuminated by looking into the area of network simulations, simulation in logistics, in military, and health. Making different scientific cultures, different challenges, and different solutions in discrete event simulation explicit is central to improving the reproducibility and thus quality of discrete event simulation research.