Masanori Yoshida of Hokkaido University designed
(J. Org. Chem.2011, 76, 8513.
)
a very simple organocatalyst for the enantioselective conjugate addition
of 21 to 20. Samuel H. Gellman of the University of Wisconsin showed
(Org. Lett.2012, 14, 2582.
)
that nitromethane could be added to 23 with high ee.
Hiroaki Sasai of Osaka University effected
(Angew. Chem. Int. Ed.2012, 51, 5423.
)
the enantioselective cyclization of the prochiral 25.
Ying-Chun Chen of Sichuan University found
(Angew. Chem. Int. Ed.2012, 51, 4401.
)
that the diene 27 could be converted to 29
by way of the intermediate trienamine.

Bor-Cherng Hong of the National Chung Cheng University observed
(Chem. Commun.2012, 48, 2385.
)
that under organocatalysis, only one enantiomer of 31 would add
to 30, delivering 32 in high ee. Aromatization of 32
led to (+)-Galbulin (33).