UniProtKB/Swiss-Prot for ZNF746 Gene

Transcription repressor that specifically binds to the 5-TATTTT[T/G]-3 consensus sequence on promoters and repress transcription of PGC-1-alpha (PPARGC1A), thereby playing a role in regulation of neuron death.

Protein details for ZNF746 Gene (UniProtKB/Swiss-Prot)

Protein attributes for ZNF746 Gene

Size:

644 amino acids

Molecular mass:

69136 Da

Quaternary structure:

Interacts (via C2H2-type zinc fingers) with PRKN.

Miscellaneous:

May act as a downstream effector of PRKN and contribute to neurodegeneration in Parkinson disease cases caused by defects in PRKN: its accumulation due to the absence of PRKN, followed by up-regulation of PPARGC1A, could lead to the selective loss of dopamine neurons in the substantia nigra.

Function for ZNF746 Gene

Products:

Molecular function for ZNF746 Gene

UniProtKB/Swiss-Prot Function:

Transcription repressor that specifically binds to the 5-TATTTT[T/G]-3 consensus sequence on promoters and repress transcription of PGC-1-alpha (PPARGC1A), thereby playing a role in regulation of neuron death.

No data available for
MalaCards ,
UniProtKB/Swiss-Prot and
Genatlas
for ZNF746 Gene

Publications for ZNF746 Gene

Reduced expression of the Kinesin-Associated Protein 3 (KIFAP3) gene increases survival in sporadic amyotrophic lateral sclerosis.(PMID: 19451621)Landers JE … Brown RH(Proceedings of the National Academy of Sciences of the United States of America 2009)34458