Second dayWednesday October 1009:00 PART II- The GRADE process: from defining thequestion and collecting evidence to rating evidencequality (G. Filippini, S. Minozzi)11:00 Coffee-break11:15 Exercise in small groups(G. Filippini, S.Minozzi)12:40 Presentation of group works and feedback frompeers and tutors13:00 Lunch14:00 PART III- Evidence to decision framework(S. Minozzi)15:00 Future initiatives (D. Taruscio)16:00 Discussion17:00 End of the course

GENERAL INFORMATIONHow to applyThe online application form is available at:https://it.surveymonkey.com/r/cpgRD2018It should be duly filled by September 25, 2018.Please note that places on the course are limited.A maximum number of 30 participants will be admitted.A confirmation of admittance will be sent by email only to the accepted applicants on September 27, 2018.Accepted participants should come with their own laptop.How much will it cost?The course is available free of charge. The organizers will provide refreshments (tea, coffee and biscuits) and lunch but will not pay for travel and accommodation expenses of attendees.Methods of AssessmentA pre-post test and a satisfaction questionnaire will be administered to the participants to assess changes in knowledge and to seek feedback on the perceived overall value and quality of delivery of the training. CME credits will not be assigned.

Course descriptionThe course intends to promote guideline quality standards in rare diseases and to support the European Reference Networks in the development of their capacity to produce and assess clinical practice.The course will provide participants with the skills necessary to develop and appraise clinical practices guidelines for rare diseases by using international methods and tools such as GRADE and AGREE.By the end of the course participants will be able to:- Describe the process of developing Clinical Practice Guidelines (CPG) for rare diseases;- Use AGREE Instruments.The course format consists of: lectures and small groups work/exercises.

Eligibility requirementsParticipants will be identified through open application.To apply for the course applicants should:- be a graduate- have experience in a health-related field- have a good command of English- be involved / interested in developing clinicalpractice guidelines for reare diseases.Applicants should meet theaboverequirements.Applications will be reviewed to determine whetherapplicants meet the eligibility requirements for admission.A geographical distribution of the participants will also be taken into account in the selection process.Priority will be done to ERN health professionals involved in developing and assessing clinical pratice guidelines