..The aim of the present study was to determine whether MYO5B mutations in these patients correlate with similar apical plasma membrane defects in renal tubular epithelial cells as observed in the intestine...

CLMP is essential for intestinal development, but does not play a key role in cellular processes involved in intestinal epithelial development

Christine S Van Der WerfDepartment of Genetics, University of Groningen, University Medical Centre Groningen, Groningen, The NetherlandsPLoS ONE 8:e54649. 2013

..Further research is needed to determine the role of CLMP in the development of the intestine...

..Based on pharmacological and cell biological studies, it is concluded that RI-controlled PKA activity is essential for cAMP- and oncostatin M-stimulated development of apical bile canalicular lumens...

..Recent evidence of cross-talk and/or overlap between the different cell-cell junction components and alternate functions of junction components, including gene expression regulation, are discussed in the context of cell surface polarity...

..They also are born with intestinal malrotation. Because CSBS occurs in many consanguineous families, it is considered to be an autosomal-recessive disorder. We aimed to identify and characterize the genetic factor causing CSBS...

..Overexpression of GTP-locked rab3b inhibits dIgA-stimulated transcytosis. Together, our data demonstrate that a rab protein can bind directly to a specific cargo protein and thereby control its trafficking...