CHICAGO — Jacob deGrom’s kind of town wouldn’t have a Wrigley Field in it.

For the second time in as many career starts at the Friendly Confines the Mets right-hander got bloodied, with the home-run ball playing a significant role in his downfall.

On Monday, deGrom surrendered blasts on consecutive pitches in the first inning, and the Mets never recovered in a 4-3 loss to the Cubs in front of 32,980.

The Mets (20-12) made noise in the middle innings against Jon Lester, but couldn’t catch a break late, with hard-hit balls against the Cubs bullpen turned into outs. It marked the sixth time in eight games the Mets scored three runs or fewer.

Top pitching prospect Noah Syndergaard will make his major league debut Tuesday, and the Mets can only hope he does a better job keeping the ball in the park than deGrom, who surrendered a mammoth two-run blast to Kris Bryant in the first inning before Anthony Rizzo homered on the next pitch.

“It boils down to location,” deGrom said. “Tonight I struggled with it and I think that makes me get off my game plan.”

DeGrom (3-4) lasted only five innings and surrendered four earned runs on five hits with five strikeouts and four walks. It was a third lackluster start in the last four for the right-hander, who saw his ERA increase to a pedestrian 3.46.

“We’ve got to get him back on track,” manager Terry Collins said.

In his no-decision at Wrigley last June, deGrom allowed four runs over five innings, including a two-run homer to pitcher Travis Wood.

Lucas Duda and Wilmer Flores hit consecutive homers in the sixth Monday to pull the Mets within 4-3, but the knockout punch never came. Duda hit a line-shot in the eighth with a runner aboard that Rizzo snared at first base and turned into an inning-ending double play before Starlin Castro robbed Dilson Herrera in the ninth with a diving grab at shortstop.

The Cubs already led 3-1 in the fourth when Addison Russell slapped an RBI single against deGrom to extend the lead.

Kevin Plawecki’s RBI single in the top of the inning was the Mets’ first sign of life against Lester (3-2), who allowed three earned runs over six innings.

DeGrom threw two straight 94-mph fastballs over the plate in the first inning that landed behind the ivy-covered walls to put the Mets in a fast 3-0 hole.

The phenom Bryant hit a two-run homer that landed three-quarters of the way up the new bleachers in left field before Rizzo hit the next pitch over the right-field wall. The homers were the fifth and sixth allowed this season by deGrom in seven starts.

The 22-year-old Syndergaard is next.

The stud pitching prospect will follow Matt Harvey (2012), Zack Wheeler (2013) and deGrom (2014) as highly touted Mets pitchers who have broken into the majors during general manager Sandy Alderson’s regime.

“That’s what Sandy told me when I signed over here, that we have a lot of pitching arms and a lot of guys that are coming,” said Curtis Granderson, who joined the Mets on a four-year contract before the 2014 season. “And sure enough he’s been right on when it came to that assessment.”

Syndergaard was 3-0 with a 1.82 ERA in five starts for Triple-A Las Vegas with 34 strikeouts and eight walks over 29 ²/₃ innings. The vacancy in the rotation that Syndergaard needed was created Friday, when Dillon Gee was placed on the disabled list with a strained right groin.

The Mets fully expected to see Syndergaard at some point last season, but after an impressive spring training he struggled for Las Vegas, where he went 9-7 with a 4.60 ERA over 26 starts.

“I’ve just become a little bit more comfortable with uncomfortable situations, like throwing breaking pitches in fastball counts,” Syndergaard said. “Last year taught me how to struggle and how to handle adversity.”