Project: Structure-function study of human ATP-citrate lyase as a target for drug design in the treatment of hyperlipidemia.

project duration

01-OCT-01 – 30-SEP-03

abstract

The primary objective of this study is to determine the 3D-structure of human ATP citrate lyase by means of X-ray crystallography. This s tructure, together with the structures of complexes with substrate and inhibitors, will provide a better understanding of the catalytical mechanism and will make it possible that 'lead compounds', identified via 'random screening' can be optimised into physiologically active drugs.