BLADDER CANCER and Mirtazapine

BLADDER CANCER Symptoms and Causes

The bladder is a hollow organ in your lower abdomen that stores urine. Bladdercancer occurs in the lining of the bladder. It is the sixth most common type of cancer in the United States.

Symptoms include

Blood in your urine

A frequent urge to urinate

Pain when you urinate

Low back pain

Risk factors for developing bladdercancer include smoking and exposure to certain chemicals in the workplace. People with a family history of bladdercancer or who are older, white, or male have a higher risk.

BLADDER CANCER Clinical Trials and Studies

Treatments might be new drugs or new combinations of drugs, new surgical procedures or devices, or new ways to use existing treatments. The goal of clinical trials is to determine if a new test or treatment works and is safe. Clinical trials can also look at other aspects of care, such as improving the quality of life for people with chronic illnesses. People participate in clinical trials for a variety of reasons. Healthy volunteers say they participate to help others and to contribute to moving science forward. Participants with an illness or disease also participate to help others, but also to possibly receive the newest treatment and to have the additional care and attention from the clinical trial staff.

To compare the efficacy of Mirtazapine and placebo for treatment of symptoms associated with schizophrenia; To compare the efficacy of folic acid and placebo for treatment of symptoms of schizophrenia; To compare the efficacy of Mirtazapine and placebo for treatment of negative symptoms of schizophrenia; To compare the efficacy of folic acid and placebo for treatment of negative symptoms of schizophrenia; To compare the safety and tolerability of Mirtazapine and placebo in patients with schizophrenia; To compare the safety and tolerability of folic acid and placebo in patients with schizophrenia

Change of 17-item Hamilton Depression Scale (HAMD-17) total score; The proportion of subjects at endpoint with HAMD-17≤7; The incidence and nature of overall adverse events; The incidence and nature of drug-related adverse events; The number of subject withdrawal due to adverse events during double-blind phase

Change From Baseline in Nighttime Total Sleep Time; Change From Baseline in Nighttime Number Of Awakenings; Change From Baseline in Nighttime Wake After Sleep Onset; Change From Baseline in in Daytime Total Sleep Time; Change From Baseline in Number of Daytime Naps; Change in Cognitive Function (as Measured by the Mini-Mental State Examination); Change in Activities of Daily Living (The Index of ADL - Katz); Change of Baseline in Behavioral Variables (BAHAVE-AD Scale); Change From Baseline in Cognitive Function (Digit Symbol Substitution Test)

increase in weight as measured in the clinic; Proportion of population achieving clinical response as measured by rate of fall in HAM-D 24 item scores; Proportion of patients achieving remission at end of study on HAM-D 24 (<11); Frequency of adverse events; Percentage adhering to medication

Categorial response to the medication. Categorial response is defined on the basis of CGI Improvement scale and 50% reduction in MADR-S score; Tolerability of treatment as assessed using the DOTES scale; Cognitive deficits as judged by the SKT system; Self assessment of depression and anxiety using Beck's Depression/Anxiety Inventory (BDI/BAI); Changes is blood levels of homocysteine, folate, vit B12, P11

If you think you may have a medical emergency, call your doctor or 911 immediately.

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