Researchers study differences in ischemic stroke in marijuana users

Stroke in marijuana users more often caused by narrowing of arteries in skull -

A new study found strokes in young adults who use marijuana are more likely to be caused by stenosis, narrowing of the arteries, in the skull than strokes in non-users.

Previous studies have found an association between marijuana use and stroke, but the new study published as a research letter in the November 3 issue of the Journal of the American College of Cardiology is the first to explore differences in stroke in marijuana users and non-users, an approach that can help researchers begin to identify possible mechanisms for stroke in users.

The researchers from The University Hospital of Strasbourg in Strasbourg, France, looked at all patients under age 45 admitted with ischemic stroke from 2005 to 2014, creating a study cohort of 334 patients, including 58 who were marijuana users. Ischemic stroke is caused by a blockage that interrupts or reduces blood flow to the brain as opposed to hemorrhagic stroke, which occurs when a blood vessel in the brain leaks or ruptures.

In marijuana users in the study, ischemic stroke was more likely to be caused by intracranial arterial stenosis, a condition where there is narrowing the arteries inside the skull caused by a buildup of plaque. Intracranial arterial stenosis was found in 45 percent of the marijuana users in the study compared to 14 percent of the non-users.

Marijuana users in the study were younger, more likely to be male, more likely to smoke tobacco, and more likely to have other lifestyle risk factors than non-users in the study.

Cardio embolism, a blood clot formed elsewhere in the body that moves to the brain, was most common cause of ischemic stroke in non-marijuana users in the study. Investigators found 29 percent of strokes in non-users were caused by cardio embolism compared to only 14 percent in the marijuana users.

"Fighting stroke must remain a priority, including in young adults," said the authors, led by Valerie Wolff, M.D., PhD. "The first step may be to inform the public regarding the potential occurrence of stroke associated with cannabis and other lifestyle risk factors.

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“One of the most concerning aspects of our findings is that we found a significant portion of responders have new onset cognitive impairment when many of them were cognitively normal within just the past few years.”