Is it possible to configure Nisus Writer (Express or Pro: the problem is in both) to save and reuse a page layout, with zoom level, window position, etc., so that when I create a new document, the document window is always the same, in the same place on my monitor, etc.

As it is now, I can resize, set zoom level, move the window, and save the document, and when I reopen that document, it comes back up perfectly. But when I create a new document, it's about half the height of my monitor, and sitting at the bottom of the display! This is quite annoying having to resize the window everytime -- surely I am overlooking something?

Go to Preferences>New Document>Advanced (tab)>Edit file... (button) and setup your New File.dot file however you want and then save it. Now whenever you create a new document it'll use that New File.dot as the skeleton for it.