Cancer: Precision T-cell therapy targets tumoursThe T cells of the immune system can destroy tumours, but their activation can be inefficient. Vaccines that exploit tumour mutations elicit robust T-cell responses to tumours, with potential clinical benefits.

Neurodegeneration: Taming tangled tauThe protein tau forms abnormal filamentous aggregates called tangles in the brains of people with neurodegeneration. Structures of two such filaments offer pathways to a deeper understanding of Alzheimer's disease.

Cancer: Keeping it real to kill glioblastomaThe results of in vitro and in vivo screens to identify genes that are essential for the survival of a type of brain cancer show almost no overlap, underlining the need for caution when interpreting in vitro studies.

Transcription elongation factors represent in vivo cancer dependencies in glioblastomaWeb An in vivo RNA interference screening strategy in glioblastoma enabled the identification of a host of epigenetic targets required for glioblastoma cell survival that were not identified by parallel standard screening in cell culture, including the transcription pause–release factor JMJD6, and could be a powerful tool to uncover new therapeutic targets in cancer.

npj Materials Degradation is a new open access journal that is now open for submissions. The journal publishes the finest content describing basic and applied research discoveries in the area of corrosion (degradation) and protection of materials.

Climate change drives expansion of Antarctic ice-free habitatPermanently ice-free areas, home to almost all of Antarctica’s biodiversity, are projected, in the worst case, to expand by over 17,000 km2 as a result of climate change by the end of this century, with potentially deleterious consequences for the continent’s biodiversity.Jasmine R. Lee, Ben Raymond, Thomas J. Bracegirdle et al.

Electron cryo-microscopy structure of the mechanotransduction channel NOMPCSingle-particle electron cryo-microscopy analysis of the mechanotransduction channel NOMPC reveals that it contains a bundle of four helical spring-shaped ankyrin repeat domains that undergo motion, potentially allowing mechanical movement of the cytoskeleton to be coupled to the opening of the channel.Peng Jin, David Bulkley, Yanmeng Guo et al.

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