Cross virus neutralizing antibodies against feline immunodeficiency virus genotypes A, B, C, D and E
Inoshima, Y.; Miyazawa, T.; Kohmoto, M.; Ikeda, Y.; Sato, E.; Hohdatsu, T.; Mathiason-Dubard, C.; Hoover, E. A.; Mikami, T.
1998-01-01 00:00:00
Feline immunodeficiency virus (FIV) is classified into five genotypes, A, B, C, D and E, based on the phylogenetic analysis of the env V3-V5 region. However, whether there is correlation between phylogenetic and antigenic diversities remains unknown. In this study, we examined the cross virus neutralization of FIV genotypes A through E by sera from cats infected with a single genotype. The results indicated some relationships between phylogenetic genotype and neutralization serotype, and that cross-clade virus neutralization is possible. For example, serum from a cat infected with genotype E virus neutralized all five FIV genotypes. Our results suggest that the FIV subtyping according to the sequence diversity is partially reflected by antigenic diversity and serum neutralization.
http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.pngArchives of VirologySpringer Journalshttp://www.deepdyve.com/lp/springer-journals/cross-virus-neutralizing-antibodies-against-feline-immunodeficiency-RtJKKe5hoF

Abstract

Feline immunodeficiency virus (FIV) is classified into five genotypes, A, B, C, D and E, based on the phylogenetic analysis of the env V3-V5 region. However, whether there is correlation between phylogenetic and antigenic diversities remains unknown. In this study, we examined the cross virus neutralization of FIV genotypes A through E by sera from cats infected with a single genotype. The results indicated some relationships between phylogenetic genotype and neutralization serotype, and that cross-clade virus neutralization is possible. For example, serum from a cat infected with genotype E virus neutralized all five FIV genotypes. Our results suggest that the FIV subtyping according to the sequence diversity is partially reflected by antigenic diversity and serum neutralization.