[Objectives] Biological coagulation and oxidation of dairy cattle slurry was a process by which suspended solid (SS)in the slurry was removed by using flocculant-producing microorganisms followed by diaphragm pressure filter to separate solid and liquid, then the filtrate was biologically purified by sequencing batch reactor (SBR)model.[Methods] Dairy cattle slurry is characterized by high concentration of suspended solid, chemical oxygen demand (COD), and ammonia nitrogen. In this study, dewaterability of dairy cattle slurry facilitated by biological coagulation process was investigated through batch flask experiments, pilot scale testes and SBR experiments.[Results] Results showed that dewaterability of dairy cattle slurry was improved after biological coagulation, exhibiting a significant reduction for specific resistance to filtration (SRF)of the slurry. SRF value decreased from initial 9.8×1013 m·kg-1 to final 0.73×1012 m·kg-1 after 24 hours of biological coagulation reaction with the reduction of 99.26% compared to the control. The bio-coagulated slurry was dewatered by chamber filter press to produce a clear filtrate without SS and a semi-drying cake with the moisture content of about 60.90%. As a result, sludge volume was reduced by 87.09% compared with the control. Moreover, the semi-drying dewatered slurry cake contained similar levels of organic matter to original dairy cattle slurry on dry basis, indicating that it was conducive to its consequent reutilization. At the same time, the concentration of COD, SS, total nitrogen (TN), NH3-N, and total phosphate (TP)in the filtrate decreased to 1 776, <10, 262, 236 and 1.89 mg·L-1 from initial 91 470, 69 500, 5 125, 957 and 129 mg·L-1 with removal efficiencies of 98.06%, 99.98%, 94.89%, 75.34% and 99.85%, respectively. Furthermore, the filtrate was purified by SBR model, the effluent quality almost met the Discharge Standard of Pollutants for Livestock and Poultry Breeding:GB 18596-2001, implying that the effluent could be acted as reclaimed water. The overall disposal time was less than 48 hours which was much shorter than the traditional process.[Conclusions] Biological coagulation and oxidation process has better potential for the treatment and disposal of dairy cattle slurry.