Jacob of Serugh (Syriac: ܝܥܩܘܒ ܣܪܘܓܝܐ, Yaʿqûḇ Srûḡāyâ; 451 - November 521), one of the best Syriac authors, named by one of his biographers "the flute of the Holy Spirit and the harp of the believing church," was born at Kurtam, a village on the Euphrates to the west of Harran, and was probably educated at Edessa.

At an early age he attracted the attention of his countrymen by his piety and his literary gifts, and entered on the composition of the long series of metrical homilies on religious themes which formed the great work of his life. Having been ordained to the priesthood, he became periodeutes or episcopal visitor of IJaura, in Sërugh, not far from his birthplace. His tenure in this office extended over a time of great trouble to the Christian population of Mesopotamia, due to the fierce war carried on by Kavadh II of Persia within the Roman borders. When on January 10, 503 Amid was captured by the Persians after a three months' siege and all its citizens put to the sword or carried off as captives. A panic seized the whole district, and the Christian inhabitants of many neighbouring cities planned to leave their homes and flee to the west of the Euphrates. They were recalled to a more courageous frame of mind by the letters of Jacob In 519. At the age of 68, Jacob was consecrated bishop of Batnan, another town in the district of Serugh, but he only lived until November 521.

From the various extant accounts of Jacob's life and from the number of his known works, we gather that his literary activity was unceasing. According to Barhebraeus (Chron. Eccles. i. 191) he employed 70 amanuenses and wrote in all 760 metrical homilies, besides expositions, letters and hymns of different sorts. Of his merits as a writer and poet we are now well able to judge from P. Bedjan's edition of selected metrical homilies (Paris 1905-1908), containing 146 pieces. They are written throughout in dodecasyllabic metre, and those published deal mainly with biblical themes, though there are also poems on such subjects as the deaths of Christian martyrs, the fall of the idols and the First Council of Nicea.

Of Jacob's prose works, which are not nearly so numerous, the most interesting are his letters, which throw light upon some of the events of his time and reveal his attachment to the Miaphysite doctrine which was then struggling for supremacy in the Syrian churches, and particularly at Edessa, over the opposite teaching of Nestorius.