Nyquil Cold And Flu (Acetaminophen / Dextromethorphan / Doxylamine) is a useful combination medicine that relieves cold and flu symptoms and will help you sleep. Make sure you really need all of its ingredients.

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Relieves pain and congestion.

Tylenol Sinus (Acetaminophen / Phenylephrine) is a good combination medicine to relieve pain and congestion. Be careful to not take too much acetaminophen (APAP) each day.

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3.6/ 5 average rating with 1176 reviewsforTylenol Sinus

Upsides

Nyquil Cold And Flu (Acetaminophen / Dextromethorphan / Doxylamine) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have watery eyes, a cough, fever, and pain.

The cough medicine (dextromethorphan) works well and has very few side effects.

The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than other pain medications like aspirin or ibuprofen.

The antihistamine (doxylamine) will help you sleep.

Tylenol Sinus (Acetaminophen / Phenylephrine) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have a stuffy nose, a headache, and pain.

The decongestant (phenylephrine) has fewer side effects than other decongestants like pseudoephedrine. It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.

The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than to other pain medications like aspirin or ibuprofen.

Downsides

If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.

You shouldn't use it if you have high blood pressure.

To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.

If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.

Phenylephrine doesn't last as long as other decongestants like pseudoephedrine.

You shouldn't use it if you have high blood pressure.

To avoid hurting your liver, you need to keep track of the total amount of acetaminophen (APAP) you are taking since it is a very common ingredient in pain and cold/flu combination medicines.