Rat Intestinal Kallikrein

Abstract

Aqueous extracts of mammalian gut wall were shown by Werle and his colleagues (1960) to contain a trypsin-activated hypo-:tensive activity. They called this activity a kallikrein although they presented no direct evidence that kinin release was involved. Ammdsen and Nustad (1965) noted that simple saline extracts from intestinal activity. They called this activity a kallikrein although they presented no direct evidence that kinin release was involved. Amundsen and mucosae of rats and rabbits released a smooth muscle stimulant from treated human plasma. However, they did not characterize either the smooth muscle stimulant or the nature of its release. In a recent review, Webster (1970) has suggested that the activities involved in these two studies were not, in fact, kallikreins, but other “endogenous proteases”.

Keywords

Hydrolysis Toluene Polypeptide Ketone Arginine

This work was supported by an M.R.C. temporary research grant to Dr W. Sircus.