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miRNA Mimics/Inhibitors

microRNA mimics are double-stranded miRNA-like RNA that are designed to copy the functionality of mature endogenous miRNA upon transfection. Once these RNA fragments are introduced into cells, the miRNA mimics can bind specifically to the targeted gene. The result is posttranscriptional repression or more specifically translational inhibition of the gene. miR-mimics will act in a gene-specific fashion allowing for “miRNA-targeting” and “miRNA-gain-of-function” methods that are presently primarily used as exogenous tools to study gene function by targeting mRNA through miRNA-like actions in mammalian cells.

microRNA inhibitors are complementary, antisense single-stranded oligonucleotides to their target, endogenous mature miRNA. Synthetic miRNA inhibitor designs incorporate the reverse complement of the mature miRNA (the target site) and are chemically modified to prevent RISC-induced cleavage, enhance binding affinity and provide resistance to nucleolytic degradation. When delivered to a cell, binding of endogenous mature miRNAs to these complementary synthetic target sites is thought to be irreversible, therefore these inhibitors are presumed to sequester the endogenous miRNA, making it unavailable for normal function.

miRNA inhibitors are available as vector-based expression clones or synthetic oligonucleotides

Available as a whole human library and individual miRNA targets

Long lasting activities at very low concentrations

Cost effective and fast turnaround time

Creative Biogene can speed up your research by providing high-quality miRNA Mimics/Inhibitors, please browse our miRNA Mimics/Inhibitors collection to find your desired one. If you don’t find the miRNA Mimics/Inhibitors of your interest in our collection, we can also work for your project with the best price!