Now that the draft season is over and the regular season has arrived, the most frequent question I get is, “Would you start player X or player Y?” We’ll strive to answer those questions before you even ask them every week in our Start ‘Em or Sit ‘Em column.

Here’s how this piece will work all season long: We’ll go through every game on the slate, covering all the teams in action in the current week. Every fantasy-relevant player will fall into one of three groups: must start, conditional start, or sit. The must-start and sit labels are self-explanatory. If a player is a must-start, you need him active no matter what. If a player is a sit, you keep him on your bench unless you are absolutely desperate. The conditional start requires a longer explanation.

Conditional starters could be played or benched, depending on your unique circumstances. Think of these guys as the running backs and receivers ranked in the mid-20s through mid-30s at their positions, or the quarterbacks ranked just outside the top 10. We’ll make our best argument for playing each of the conditional starters. From there, it’s up to you. After all, it’s your team, and you should want to be in charge of it. We’re here to help you make the most informed decisions you can every week.

Green Bay Packers at Chicago Bears

The only bad news for Rodgers owners is that this game could get so out of hand that he sits the entire fourth quarter. He’s my top quarterback play for a reason this week, even though he’s going to miss Jordy Nelson. There will be plenty of scoring to go around for Rodgers and Lacy to be the top performers at their respective positions this week. Expect the Packers to easily get to 30-plus points in their first meeting with the Bears this season, which should also spell good things for Cobb and Adams. Forte remains an easy start, but the best play for Chicago might be Bennett, who could see upwards of 15 targets in this game, especially if Alshon Jeffery is out. Being on a bad team isn’t necessarily a negative for fantasy purposes.

Jeffery owners need to monitor the news leading up to kickoff Sunday. The Bears have been guarding his injury status as though it were the Manhattan Project, which probably isn’t good news. Even if he is able to go, he’s not going to be at 100%. Eddie Royal is just outside my top 25 at receiver for the week, and if Jeffery is indeed out, Royal would be a must-start receiver. Cutler can be trusted in two-quarterback leagues, especially since the Bears are likely to be playing from behind all game. The Packers are a good stream play at defense this week, going up against a quarterback they have tortured for the better part of the last six years.

Kansas City Chiefs at Houston Texans

It seems kind of crazy to say, but this is about as big as a game gets in Week 1. The Chiefs and Texans are both expected to be playoff contenders, meaning the winner will come away with what could be a very important wild-card tiebreaker. Charles and Kelce are both top-three plays at their positions this week, while Hopkins and Maclin are both in my top 12 receivers. It’ll be interesting to see how the Chiefs deploy Maclin, but he is going to help unleash the passing game in Kansas City. This game should also feature two of the league’s best defenses, even if Dontari Poe isn’t quite 100 percent.

Smith is a great play in two-quarterback leagues, and I think he can be a top-20 quarterback this year, but there’s no reason to add a degree of difficulty and roll with him in a standard one-QB league. Blue will get the start in place of the injured Arian Foster, but he’s still a long-range play. We saw enough from him last year to know that opportunity isn’t everything. The Chiefs’ defense makes it even less likely he’s worth more than a low-end flex start.

Cleveland Browns at New York Jets

Must start: Chris Ivory, Eric Decker, Jets DST

I think this Jets offense is going to be better than people expect, and that will be on display Sunday against the Browns. Ivory is going to be an 1,100-yard back this year, worthy of being, at worst, an RB2 most weeks. I think at least one of Decker or Brandon Marshall will have a nice game, and my money is on Decker with Marshall likely to see a heavy dose of Joe Haden in coverage. The Jets DST should be good this year, but you’re always going to want to pick on this Browns offense.

Fitzpatrick is worth a gamble in two-quarterback leagues, and he could eventually play his way onto the QB1 radar, but let’s make him prove that to us first. Crowell and Johnson are both interesting backs, but it’s hard to have much faith in the Cleveland backfield for now. If you’re starting them, you’re either in a deep league or very thin at running back. Marshall is the one player here who could really start in most fantasy formats, but he’s not a guy you must have out there this week. Having said that, he is my No. 25 receiver, so I’d almost certainly be getting him active.

I won’t list the entire Cleveland receiver depth chart every week. I did so this week as a public service announcement. Those really are their top five receivers. This offense could set records for futility this season.

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Indianapolis Colts at Buffalo Bills

McCoy and Hilton worried their owners earlier this week, but both should be out there when the Colts and Bills face off to start the season. While McCoy is a must start, don’t expect a huge game. That hamstring still isn’t 100 percent, and the Colts could run away and hide in this one. Johnson is set for a renaissance season with Luck throwing him the ball and should regularly post WR2 numbers. It’ll be interesting to see how Watkins performs in his first real game with Tyrod Taylor under center. At the very least, Taylor’s ability to extend plays should help the second-year wideout from Clemson. Finally, the Colts are a great stream defense, while the fact that the Bills DST is a must start should tell you all you need to know about how good this unit could be in 2015.

Taylor could very well develop into a player who is universally owned in fantasy leagues. For now, he bears watching as one of the most intriguing unknowns in the league. He’s also a low-end QB2 in two-quarterback formats. It appears Allen will lead the Colts at the tight end position again this year, but he’s not a must-start thanks to Coby Fleener’s presence. If you drafted Allen, chances are you drafted another tight end who’s a better play this week.

The two players to watch from this list are Dorsett and Clay. The former beat out Donte Moncrief to be the Colts’ third wide receiver. There’s a reason why a team that seemed set at receiver grabbed him with its first-round pick. We’ve seen Clay put together fantasy-relevant seasons in the past. Only time will tell if he can do it in a Buffalo offense that may prove restrictive.

Miami Dolphins at Washington Redskins

This is a game that has a real chance to get out of hand in a hurry. The Dolphins are my pick to win the AFC East and just may have what it takes to make a run in the playoffs. Washington, meanwhile, is my pick to be the worst team in the league this year. Tannehill will make the leap this year, and the Washington defense allowed the most fantasy points per game to quarterbacks last season. He, Landry and Cameron should all thrive. Miller was one of the most underrated backs heading into draft season, but that won’t be the case at the end of the year. On the other side, only Morris needs to be started, and I don’t have him rated any higher than a low-end RB2. If Miami builds a significant lead, he could be phased out of the game plan.

In most leagues, Jackson is going to start. Given the way he tumbled down draft boards late in the summer, however, it’s entirely possible you can fill out your lineup with better receiver options. In his defense, he had 1,169 yards and six touchdowns in a terrible situation in D.C. last year, so he can still succeed amidst the wreckage. Garcon, too, is a potential starter, though he’s much further down the pecking order. Reed has the talent to be a top-10 tight end, but hasn’t been able to stay on the field. Given that he was drafted outside the top-15 tight ends, anyone who owns him likely has a better option available.

Cousins may put the ball in the air 40 times on Sunday, but I’m not betting on him against what could be one of the best defenses in the NFL. I do think that Stills or Parker will eventually emerge as a strong second receiver and fantasy-relevant player, but both have playing-time concerns in Week 1. Keep an eye on how Parker looks as he gets his first real game action since foot surgery, and pay close attention to how often the Dolphins line up in three-wide sets.

Carolina Panthers at Jacksonville Jaguars

Stewart finally has the backfield all to himself in Carolina. An injury could pop up eventually, but we know he’s healthy Week 1, and that makes him a great play against a Jacksonville defense that looks awfully similar to the one that allowed the fifth-most fantasy points to running backs last year. Robinson appears set for a breakout season, and the Carolina secondary is quite long in the tooth (Charles Tillman and Roman Harper are starters). Get ready for a show. Olsen could very well set a single-season record for targets by a tight end this year. Don’t be surprised if he also leads all tight ends in receiving yards. The Panthers defense isn’t what it was a few years ago, but this is a nice matchup.

Newton would have been a must-start quarterback if Kelvin Benjamin were healthy, but he doesn’t have a very high ceiling without the second-year receiver on the field. Newton simply hasn’t been a consistent passer in his career, and his legs can only take him so far. He’s an easy play in two-quarterback leagues, but I’d steer clear in one-QB formats. Bortles is also an easy play in two-quarterback leagues and could provide some sneaky value in daily games. He’s a breakout candidate this season, but he isn’t quite worthy of one-QB consideration. Owners in deep leagues can consider rolling with Yeldon, who was named the Jaguars’ starter earlier this week. Still, his owners shouldn’t expect more than top-30 production, at best.

Everyone seems ready to put Funchess in the Panthers’ starting lineup. Everyone, that is, except for Ron Rivera and Mike Shula. Those are the two guys who really matter in this equation. Funchess is well worth owning at this point in the season, but let’s see what he can do before making him a fantasy starter.

Seattle Seahawks at St. Louis Rams

Must start: Marshawn Lynch, Jimmy Graham, Seahawks DST, Rams DST

If the Seahawks' offense elevates to another level this year, it will be thanks to the efforts of Russell Wilson, Lynch and Graham. You can bet you’ll see at least the latter two and usually all three in this space every week, but the Rams' fearsome front four keeps Wilson from being an absolute must-start this week. The Rams present a real test for Lynch and Graham, as well, so don’t expect them to carry your respective teams in Week 1. These will be two of the best defenses in the NFL this year. Both are essentially matchup-proof.

Quick is the lone Rams offensive player worthy of fantasy consideration in all but the deepest of leagues. My love for him this season has been well-chronicled on our pages all summer long. I think he’s ready to have the breakout campaign he was on pace for last year before a shoulder injury cut short his season. While that injury is still a bit of a concern, the fact that he was cleared for contact three full weeks before the season opener was a great sign. Remember, Kam Chancellor won’t be on the field for the Seahawks on Sunday. Quick is my No. 34 receiver in Week 1.

Todd Gurley has already been ruled out as he continues to rehab from last year’s torn ACL, and that would seem to open the door for another St. Louis back. Unfortunately, Mason is dealing with a hamstring injury, and there’s no way anyone should be considering starting Cunningham against the Seattle defense. Foles could be a decent QB2 in two-quarterback leagues this season, but this isn’t a great matchup, even with Chancellor still holding out.

New Orleans Saints at Arizona Cardinals

The Saints offense could very well take a step backward this season. Jimmy Graham is gone, and there’s more uncertainty surrounding the passing game than ever before in the Drew Brees-Sean Payton era. Still, this feels like a bankable fantasy offense, with Brees, Mark Ingram and Brandin Cooks leading the way. All should go in a tough matchup with the Cardinals. Andre Ellington is a low-end RB2 for Week 1, but he could be a disappointment this season. He has big-play ability, but he might not be durable enough to rack up the touches necessary to be a fantasy star.

This Saints defense, especially the secondary, is in a bad way right now, and Palmer could be the main beneficiary. Both he and Brown are on the cusp of being must-start players, and Brown is likely to be in many starting lineups, depending on your league format. Floyd looks like a game-time decision for this week, and he’d really only be a go in deeper leagues. When both are healthy, I prefer Floyd because I think he can do more in the route tree, but Brown is undoubtedly dangerous on Sunday. For me, Palmer is a high-end QB2.

Who’s going to step up and be the second pass catcher for the Saints? That’s a question the fantasy community should be focused on early in the season. Coleman probably has the highest ceiling, but can the second-year man supplant Colston? Can Josh Hill give the team a reliable tight end? On the other side, keep a close eye on David Johnson’s usage. He could quickly turn into a fantasy-relevant player.

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Detroit Lions at San Diego Chargers

I’m this close to calling Abdullah a conditional start, but he’s my No. 23 running back this week, and I can’t see bumping up any of the guys right behind him. If he’s on your team, the last thing you want to see is him returning kicks and punts, though. That’s a definite net negative for a back’s fantasy value. Then there’s that other Big Ten rookie running back in this game. Gordon slipped down draft boards for much of the summer, largely because of his issues with pass protection. While he will give up third-down duty to Danny Woodhead, the idea that the veteran will cannibalize his fantasy value is laughable. Gordon should dominate the carries for this team, and that will make him a solid RB2 this year. If Johnson is healthy for 16 games, he and Tate could very well be the best receiver duo this year.

Stafford and Rivers are both outside my top-12 quarterbacks this week, so you’ll likely have to be in a deeper one-quarterback league to ride with them in this matchup. Stafford, however, was a bit undervalued during draft season and could definitely get back into the top 10 at the position this year. Both are strong QB2s for Week 1. If you drafted Allen, you definitely like him more than I do. I just don’t see a ton of value in a receiver who has had four catches on passes that traveled at least 20 yards in the air in two years. I wouldn’t play him, but then again, I wouldn’t own him. Woodhead is really only worth thinking about in full PPR leagues, while Bell can be a low-end flex in a standard 12-team league.

Both of these tight ends could find themselves in starting lineups later in the year. Ebron and Green are athletic, catch-first tight ends who should post above-average numbers. If I had to own one receiver on the Chargers, I’d want it to be Johnson.

Tennessee Titans at Tampa Bay Buccaneers

It feels odd to list Sankey among Week 1’s must-start plays, but I expect him to handle the ball 20 times in a decent matchup with the Buccaneers. He has a chance to take the starting gig and run with it this year. It needs to begin with a good performance on Sunday. Martin is another running back in need of a fast start this season. After disappointing for two straight seasons, Martin once again has the fantasy community believing he can rebound. Evans is dealing with a hamstring injury, but he looks set to give it a go on Sunday. If he can put this injury behind him quickly, he can establish himself as a top-10 receiver this year. There’s nothing flashy about Walker, but he should be a low-end TE1 in 2015.

Neither Wright nor Seferian-Jenkins is an advisable start, but some people are going to find themselves in a spot where they have to play someone like that. Wright is a bit more attractive in PPR leagues, especially since Marcus Mariota will be making his first career start. The same could be said about Seferian-Jenkins and his relationship with Jameis Winston. The big tight end heads into 2015 with a high ceiling. He can be a real weapon for Winston in the red zone. Jackson is clearly on the downside of his career, but he did top 1,000 yards last season. He’ll likely vacillate between WR2 and WR4 production from week to week.

Mariota and Winston will likely be compared with each other all season, just like famous pairs such as Peyton Manning– Ryan Leaf and Andrew Luck–Robert Griffin III before them. It’s only fitting that they meet each other in the first game of their careers. Both could be considered in deeper two-quarterback leagues, but they’re not yet on the QB1 radar. If someone could emerge from the murk surrounding the Tennessee receiver depth chart opposite Wright, that receiver could be a WR3 type for the length of the season. Don’t be tempted to play Murphy if Evans can’t go on Sunday.

Cincinnati Bengals at Oakland Raiders

I’m a big believer in the Bengals this season. Green, Eifert and Marvin Jones are fully healthy. Hill and Giovani Bernard could be the league’s best 1–2 backfield punch. It’s all up to Dalton to guide the ship, and I think he will prove himself more than capable. They’re going to make a statement against the Raiders in Week 1. All four of the offensive players for the Bengals listed in this section—yes, including Dalton—are slam-dunk plays in my book. I’m a little nervous about Murray, especially if this game gets out of hand. His draft-day value was based largely on one game in which he had a 90-yard touchdown run. Be careful here.

Bernard and Cooper will both be must-start plays at certain points of the season, but I could see both being on benches this week. In Bernard’s case, it’s hard to envision a starting fantasy role for him right away when you have your entire roster at your disposal. He can make a lot out of being a receiver and change-of-pace back, but you don’t want to lean on him too heavily. Cooper is a world-class talent, but the low ceiling of the Oakland offense could hold him back.

Carr and Jones are the players of import here. Murray and Cooper can help bring Carr to another level this year, but he got fewer than 5.5 yards per attempt last year. That’s simply a dreadful number. Jones had 10 touchdowns two years ago, and while that was a bit of a fluke—he had just 51 receptions—he’s certainly talented enough to turn in a top-40 season. Sanu did so last year, and Jones is undoubtedly the superior receiver.

Baltimore Ravens at Denver Broncos

So Manning can’t really throw the deep ball anymore. Is that really much different from the Manning who turned in another top-five season last year? He’s going to be just fine, and so is this offense. They’ll prove it against the Ravens on Sunday. There’s legitimate reason to be worried about Forsett, but there was nothing fluky about what he did last year, and Marc Trestman has had a track record of turning running backs into pass-catching stars. Forsett could catch upwards of 65 passes this year. Keep your expectations in check for this tough matchup with the Broncos, though.

Conditional start: Joe Flacco, Steve Smith Sr.

Baltimore’s QB–WR combo is on the outside looking in at the starting class in my Week 1 rankings, and I think there’s reason to believe they fall short of what they accomplished last season. Even with Trestman in tow in a much more comfortable role than he had in Chicago, there’s no receiver in this offense who scares defenses other than Smith. Last year, Torrey Smith was there to take pressure off the veteran and give Flacco a reliable deep threat. His absence is really going to hurt this team.

Watch how the Ravens rotate backs behind Forsett. Allen has the right pass-catching skills to be a weapon in Trestman’s offense. It’ll be interesting to see how he and Taliaferro are used. Aiken’s greatest impact on the fantasy game this year might be keeping Breshad Perriman buried on the depth chart.

New York Giants at Dallas Cowboys

Manning/Beckham against Romo/Bryant should be a perfect way to finish off the first Sunday of the 2015 season. Expect all four players to star for their fantasy owners in what is always an entertaining NFC East clash. Now that DeMarco Murray is in Philadelphia, Witten should have a larger role in the Dallas offense. He spent so much of his time blocking for Murray last year, but that won’t be the case with the Cowboys still trying to figure out the right backfield mix heading into Week 1. He should get back inside the top 10 at the position this season.

These teams are nearly mirror images of one another on offense. Both have elite QB/WR duos, cloudy backfield situations, and boom-or-bust second receivers. Do you have the guts to roll the dice on Randle or McFadden? If one could separate himself, he’d likely be a low-end RB2, but it could take a few weeks before one of them is able to create some distance. Jennings begins the season as the starter, but Andre Williams lurks not far behind. Vereen can be a PPR darling, but he flopped in his final year with the Patriots. Randle and Williams are better cast as fliers in daily leagues than starters in season-long formats.

Cruz will almost certainly miss Week 1, and fantasy owners definitely can’t afford to roll the dice and wait for the Giants to unveil his status given that this is the Sunday night game. If he can get to 100% early in the year, he can still be a weapon, but there’s a chance that last year’s knee injury will hold him back from ever being the same receiver.

Philadelphia Eagles at Atlanta Falcons

At 56.5, this game’s over/under is the highest for Week 1. Expect the passing attacks, led by Bradford and Ryan, to drive the scoring. Both are top-10 plays this week. Their top receivers, Matthews and Jones, should be able to post WR1 numbers in favorable matchups. From a fantasy perspective, the most intriguing part of this game will be how Chip Kelly uses Murray in his first game as an Eagle. This is a team nursing legitimate Super Bowl hopes. It’ll need Murray upright in January to get there. Will he get to 300 carries in Philadelphia this season?

All four of these players are right on the fringes of the starting class, with Coleman and Agholor just barely outside, assuming the talent in your league is split evenly. Coleman has a chance to assert himself as the Falcons' starter with Devonta Freeman still hobbled by a hamstring injury. If he can widen the gap, he could very well turn into a draft-day steal. Mathews’s day is coming, but the only way you should be considering him as a starter is if you went the zero-RB route, or if you’re in a league with a minimum of 14 teams.

If there’s one good thing to say about this group, it’s that Hankerson could be a decent punt play in daily leagues. There always seems to be that one receiver who comes out of nowhere to have a big Week 1. Hankerson fits that bill perfectly, especially when you consider that this should be a high-scoring affair.

Minnesota Vikings at San Francisco 49ers

Must start: Adrian Peterson, Carlos Hyde, Vikings DST

Peterson is going to get all the press in this game, and justifiably so. His return to the field is a huge draw, which is partially why this game is in prime time. There’s some legitimate concern about him being a bit rusty since he hasn’t played a game in more than a year, but he’s still a freakishly talented back going up against a depleted defense. Don’t lose sight of the fact that this game doubles as Hyde’s first career start. He seemed to fly under the radar at the end of draft season, seeing his ADP land at the end of the third round. He’ll soon turn 24 and could be the breakout running back of 2015.

Bridgewater and Kaepernick both have low-end QB1 upside for the entire year, and I’d be starting either if I owned them in a two-quarterback league. Bridgewater is one of the most popular breakout picks this year, with the second-year quarterback garnering so much praise that he has helped turn the Vikings into a chic playoff pick. If he improves at throwing the deep ball, he could be the total package. Kaepernick, meanwhile, will be a force on the ground, as always, and he’s going to get in the end zone more than he did last year. Kaepernick had just one rushing score despite 639 rushing yards in 2014, which is nearly impossible. He also has a pair of underrated receivers in Boldin and Smith. Both of them can be started in the right circumstances this week, especially Boldin, who has averaged 1,120.5 yards and six touchdowns in his two seasons with the 49ers. Finally, if you believe in Bridgewater, you have to believe in at least one of Johnson or Wallace. The former is my bet to be the Louisville product’s go-to receiver this year. Like Boldin, I’d be starting him this week unless I’m very deep at receiver, and I love him in daily formats.