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Injectable Drug Delivery System with Cyclodextrin-polymer Based Hydrogels

Exploit Technologies Pte LtdSingapore

Abstract ID:

Our cyclodextrin-polymer based injectable hydrogel comprises of cyclodextrin, which is biodegradable, biocompatible and may be naturally or artificially synthesized, a polymer and at least one drug...

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FULL DESCRIPTION

Various types of polymers that are used for controlled release and delivery of drugs have been developed in the past 20 years. Most of the polymers are formed into implants or injectable microspheres. Such polymers must be biodegradable and biocompatible. Currently, complicated fabrication processes are usually required which involve the use of organic solvents where traces of such organic solvents may be toxic or may sometimes cause denaturation of some protein drugs. Polymer hydrogels have been explored for drug delivery and controlled release. Injectable drug delivery systems can form chemical cross-linked hydrogels in the body after injection. However, chemical reactions in the body may cause tissue irritation and damage. Temperature sensitive gels are also not practical to be injected. By developing an improved hydrogel system for delivery and controlled release of drugs into the body, fabrication processes would be made easier and also allowing a wider variety of drugs to be delivered or released.

Our Innovation

Our cyclodextrin-polymer based injectable hydrogel comprises of cyclodextrin, which is biodegradable, biocompatible and may be naturally or artificially synthesized, a polymer and at least one drug. The new cyclodextrin polymer-based injectable hydrogel would:

(1) Provide a sustained, controlled release matrix for the drug.

(2) Hydrogel is bioabsorbable, thermosensitive, and thixotrophic and undergoes reversion between gel and sol under certain conditions.

(3) Formation of hydrogel is very simple and easy.

(4) The properties of the hydrogels are tunable with different copolymers allowing delivery of a variety of drugs, which includes protein drugs, vaccines, and also allows for the sustained, controlled release of the drugs, genes, vaccines etc.