This bee nests in salt-saturated, or alkaline, soil. Like some other bees such as Megachile rotundata, alkali bees are an effective pollinator of alfalfa.[2] The bee uses a specialized technique of opening alfalfa flowers for pollination by applying pressure to snap open the keel of the flower. Due to the unusual nesting habits of this bee, farmers have developed methods to accommodate them with salty mud-fields where they can burrow and lay their eggs. Farmers started doing this after realizing that plowing up natural flats like these decreased the yield of alfalfa dramatically.[3][4]

Juvenile hormone (JH) analog methoprene can serve as a possible limiting factor for alkali bees since female bees are more likely to reach reproductive maturity with JH.[6] Alkali bees are also considered solitary bees because females have their individual nests and live alongside other female alkali bees.