Sophronia "Phronsie" Pepper, the youngest child in the Pepper family, of Margaret Sidney's children's books
Sophronia Lammle, character in Charles Dickens' novel "Our Mutual Friend"
"Advice to Sophronia", poem by Mary Leapor
Sophronia/Sofronia, character in the epic poem "Jerusalem Delivered" by the Italian poet Torquato Tasso
The USS "Sophronia", motorized schooner purchased by the Union Navy during the first year of the American Civil War
In Nina Simone's song "Four Women," one of the four women is Saphronia.