What causes the deficiency of uroporphyrinogen decarboxylase seen in porphyria cutanea tarda?

80% acquired20% autosomal dominant

What is porphyria cutanea tarda?

What cutaneous manifestations are associated with porphyria cutanea tarda?

Chronic blistering skin lesions on sun exposed areas of the body (face, ears, neck, forearms, back of the hands, etc…) because the porphyrins that accumulate are photosensitizing.hyperpigment, hypertrichosis

225

What notable pharmacology correlate is associated with acute exacerbations of porphyrias?

barbituates (p450 inducers)

226

What are some hepatic manifestations associated with porphyria cutanea tarda?