...rancisco, California, is investigating the molecular mechanism by which the hsp90 protein chaperone affects the folding of substrate proteins. The effect of hsp90 on folding is important because this chaperone activates a wide variety of ...

...we had to target Heat Shock Protein 90 (HSP90).
hsp90 is already a therapeutic target in many other type...e effectiveness of an antibiotic called 17/AAG, an hsp90 inhibitor, against malignant tumours of the skin, ...ell lines. Our results clearly prove not only that hsp90 is largely overexpressed in this type of tumour bu...

...eldanamycin inhibited Ack1 through interference with its molecular interactions, 'If you add geldanamycin to the prostate cancer cell, the drug knocks hsp90 off oncogenic signaling molecules. This dramatically decreases Ack1 activity and slows tumor formation,' Earp added. The team also found that Ack1 lev...

... treatment. First, the group discovered that Ack1 bound to a protein called hsp90 (heat shock protein 90), which associated with many oncogenic, or cancer-ca...
'If you add geldanamycin to the prostate cancer cell, the drug knocks hsp90 off oncogenic signaling molecules. This dramatically decreases Ack1 activit...

...dynamics and pharmacokinetics of AUY922 in a Phase I study of solid tumor patients
These data support the use of HSP70 as a biomarker for hsp90 inhibition. Inhibition of HSP90, a key target that regulates tumor cell survival and division, through the use of AUY922, resulted in an up regulation...

Dr. Dan Gewirth, Hauptman-Woodward senior research scientist, has just solved the structure of the first mammalian GRP94 protein implicated in immune diseases such as sepsis, AIDS and certain cancers. His work is being published today in a cover article in a top scientific journal - Molecular Cel...

...searchers say.
"We are trying to understand how hsp90 folds steroid receptors into the proper conformati...h their function when they are helping cancer."
hsp90 is vital to steroid receptors whether they are inv... with normal hormonal function or cancer. Vital to hsp90 are helpers such as p23 that help it dock at the r...

...Mitochondrial Homeostasis by an Organelle-Specific hsp90 Chaperone Network, published in the October 19 iss...agues sought to both define the mechanism by which hsp90 leads to tumor cell stability and survival, and understand why general suppression of hsp90 has not been as successful in clinical trials.
...

...tions of a heat-shock protein known as Hsp90.
hsp90 belongs to a family of proteins called chaperones ...ntain their 3-D structure. Unlike most chaperones, hsp90 is dedicated to assist a restricted yet diverse gr... glucocorticoid receptor, which requires help from hsp90 to interact with hormones. Scientists had been sty...

...thers believed that the proteins -- RAR1, SGT1 and hsp90 -- were required for what is called signal transdu... defense response," Holt said. "The proteins RAR1, hsp90 and SGT1 were previously thought to work together ...why they antagonized each other, he said. RAR1 and hsp90 can prevent resistance proteins from disappearing,...

...thers believed that the proteins -- RAR1, SGT1 and hsp90 -- were required for what is called signal transdu... defense response," Holt said. "The proteins RAR1, hsp90 and SGT1 were previously thought to work together ...why they antagonized each other, he said. RAR1 and hsp90 can prevent resistance proteins from disappearing,...

...tlake discovered that a chaperone protein known as hsp90 is involved in conferring green tea's protective e...many cancer cells have an increase in the level of hsp90 compared to healthy cells, and that when hsp90 is blocked, levels of proteins that make cancer ce...

CAMBRIDGE, Massachusetts and LAUSANNE, Switzerland, August 6 /PRNewswire/
-- Curis, Inc. (NASDAQ: CRIS ), a drug development company focused on
developing proprietary targeted medicines for cancer treatment and Debiopharm
Group (Debiopharm), a group of companies with a focus on the developme...

Company to develop for treatment of neurofibromatosis and cancer
NEW YORK, Sept. 26 /PRNewswire/ -- NexGenix Pharmaceuticals Holdings,
Inc., a privately held New York biotechnology company focused on developing
drugs to treat the genetic disorder neurofibromatosis and related sporadic
tumo...

...be of significant value to
Kosan as we advance our hsp90 inhibitor and epothilone programs through
later st...nticancer agents through clinical development -- a hsp90 (heat shock
protein 90) inhibitor and an epothilone. hsp90 inhibitors have a novel
mechanism of action target...

...cing two new classes
of anticancer agents through clinical development -- a hsp90 (heat shock
protein 90) inhibitor and an epothilone. hsp90 inhibitors have a novel
mechanism of action targeting multiple pathways inv...

...ve forward with
research investigating the role of hsp90 in the progression of many
cancers. "I am excited ... prospect of utilizing this antibody to
target the hsp90 chaperone and to potentially curtail the metastati...tool to explore the
role of cell surface localized hsp90 protein in cancer progression. Since
this antibody...

...cing two new classes
of anticancer agents through clinical development -- a hsp90 (heat shock
protein 90) inhibitor and an epothilone. hsp90 inhibitors have a novel
mechanism of action targeting multiple pathways inv...

...-- NexGenix Pharmaceuticals, presented
data on its hsp90 inhibitor program today at the Annual Meeting of t...eutic
window compared to 17AAG, the first-in-class hsp90 inhibitor currently in
Phase 2 clinical trials for cancer.
The compound series appears to bind hsp90 in a different mode than
17AAG or radicicol and ex...

Description:... (HSPs), more appropriately called as stress response proteins (SRPs). The hsp90 family of proteins in mammalian cells consists of hsp90 alpha and beta, Grp94, and Trap-1 (Hsp75). It was found that human TRAP-1 i...Company:Lab Vision

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