The purpose of this study is to identify changes to the metabolome (range of chemicals produced in the body) and microbiome (intestine microbe environment) that are unique to Roux-en-Y gastric bypass surgery and assess the associated effect on the metabolism of patients with type 2 diabetes.

The purpose of this study is to evaluate the effects of improving glycemic control, and/or reducing glycemic variability on gastric emptying, intestinal barrier function, autonomic nerve functions, and epigenetic changes in subjects with type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) who are switched to intensive insulin therapy as part of clinical practice.

The purpose of this study is to test the hypothesis that patients with T2DM will have greater deterioration in BMSi and in cortical porosity over 3 yrs as compared to sex- and age-matched non-diabetic controls; and identify the circulating hormonal (e.g., estradiol [E2], testosterone [T]) and biochemical (e.g., bone turnover markers, AGEs) determinants of changes in these key parameters of bone quality, and evaluate the possible relationship between existing diabetic complications and skeletal deterioration over time in the T2DM patients.

The purpose of this study is to evaluate glucose variability in patients with type 1 diabetes (T1D) and insulin antibodies, to evaluate the clinical significance of insulin antibodies, and to establish an in vitro assay that would detect antibodies to insulin and insulin analogs.

The primary goal of this study protocol is to determine the candidate ratio of pramlintide and insulin co-infusion in individuals with type 1 diabetes (T1DM) to enable stable glucose control during the overnight post-absorptive and in the postprandial periods.

The purpose of this study is to estimate the risk of diabetes related complications after total pancreatectomy. We will contact long term survivors after total pancreatectomy to obtain data regarding diabetes related end organ complications.

Adults who gain most of their excess weight in abdominal area or have Type 2 (adult onset) Diabetes typically do not process sugar (glucose) normally in their muscle in response to insulin, especially compared to lean adults or those who have gained most of their excess body fat in their hip and thigh areas. We know that some of this is due to differences in how fat cells release fat molecules into the bloodstream, which in turn affects muscle metabolism. We don’t know whether fat molecules in the bloodstream are handled differently by those with abdominal fat gain, type 2 diabetes or hip and thigh fat gain compared with lean adults. By measuring how muscle handles fat molecules in the bloodstream and how that relates to the ability of insulin to help the muscle use glucose, we will help understand the interaction between fat cells and muscle as it relates to diabetes-related diseases.

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