А method of forecasting obstetric and perinatal complications in pregnant women with pre-eclampsia associated with thrombophilia was developed. The calculation of the probability of complications in pre-eclampsia, associated with thrombophilia, can detect pregnant women with high risk of complications and to determine the possible term of pregnancy prolongation. Delivery is indicated if the risk of complications is over 0,632 and/or when the signs of the aggravation of the fetus or the mother are registered and after the prevention activities of fetus respiratory distress syndrome.