The intercalation of captopril (CP) into the interlayers of montmorillonite (MMT) affords an intestine-selective drug delivery system that has a captopril-loading capacity of up to ca. 14 %w/w and which exhibits near-zero-order release kinetics.

Mentions:
Accurately weighed amounts of MMT nanoclay (ca. 1, 2 or 5 g) were dispersed separately in vessels containing deionized water (100 ml) and allowed to stand for about 15 h and stirred (magnetic stirrer) for 24 h. The colloidal stability of the dispersions was assessed visually over 24 h. Since all dispersions appeared stable within this timescale, the more concentrated, 5 %w/w MMT, dispersion was selected for further evaluation (Figure 3).

Mentions:
Accurately weighed amounts of MMT nanoclay (ca. 1, 2 or 5 g) were dispersed separately in vessels containing deionized water (100 ml) and allowed to stand for about 15 h and stirred (magnetic stirrer) for 24 h. The colloidal stability of the dispersions was assessed visually over 24 h. Since all dispersions appeared stable within this timescale, the more concentrated, 5 %w/w MMT, dispersion was selected for further evaluation (Figure 3).

The intercalation of captopril (CP) into the interlayers of montmorillonite (MMT) affords an intestine-selective drug delivery system that has a captopril-loading capacity of up to ca. 14 %w/w and which exhibits near-zero-order release kinetics.