Since the purchase contract with former owner Capstone Realty Advisors was reported in November, it hasn’t been exactly clear what medical uses Macklowe had in mind for the 12-story, 1955-vintage address across the street from New York Presbyterian-Lower Manhattan Hospital.

On Monday, Macklowe said he views the hospital’s proximity as a “demand driver” for services that might include a ground-floor medical imaging center.

He said the six months before the city moves out gives him time to plan the building’s repositioning, which will include enhanced electrical and water capacity among other changes to support medical uses.

“We’re not trying to create a hospital,” Macklowe said, but rather to “tenant the building in a way not dissimilar to tenanting a mall, where you have an anchor tenant” that others in the location can feed off. An imaging center for procedures such as MRI’s and CAT- and full-body scans might be such an anchor.

The purchase — for a mere $250 per square foot — is the first in FiDi for Macklowe, who’s staked out his claim in Midtown and Midtown South since he formed his own company separate from father Harry Macklowe’s in 2010.

Among Billy’s holdings is the original Bowlmor Lanes building at 110 University Place. When we reported in 2012 that Macklowe had gotten control of the property, we wrote that the bowling alley’s remaining lease term was unknown.

Macklowe declined to comment this week.

But we’ve learned from brokers that leases for Bowlmor and a garage at the site expire imminently as does a garage lease — and that demolition for a new building will likely start this summer.

Asking rents at the address are $62 per square foot. The move marks WeWork’s first plunge into thriving Midtown South.

Landlord principal Stephen Meringoff said, “Having toured a number of their locations and understanding what they have on the horizon, we recognized that 401 Park Ave. South would be an ideal location for their business, since the neighborhood has become the axis of the city’s burgeoning technology and creative industries.”

One thing on WeWorks’ horizon is a prospective move to Rudin Management’s 110 Wall St., where a deal’s now being negotiated for the firm to occupy the tower’s entire 300,000 square feet.

WeWork provides open spaces tailored to encourage collaboration along with advanced infrastructure and other services essential to start-ups.