Preclinical Study Design in SOD1 Mouse Models

Leitner M, Menzies S, and Lutz C. This manual summarizes the current best practices and recommendations available for (1) designing and conducting preclinical studies using the currently available SOD1-based mouse models of ALS and (2) breeding and maintaining SOD1 mutant mouse colonies. The manual was prepared through a joint collaboration with The Jackson Laboratory and Prize4Life, Inc.

Design, power, and interpretation of studies in the standard murine model of ALS. [Pubmed]