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OSX 10.5 includes Python 2.5 that support Django 1.0. Do not use Mac port to install Python2.5. Mac port Python 2.5 won't support Django 1.0. Python 2.5 includes SQLite3.

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OSX 10.5 includes Python 2.5 that support Django 1.0. If you want to use MacPorts version of Python, you must install additional packages if you want to use SQLite as your database (py25-sqlite3 and py25-hashlib).