Continuity mistake: In the episode where Brian and Lois get married, Lois confronts Brian after cheating with Peter back at the house. Stewie is playing with a SIMON SAYS game. Look at the SIMON SAYS when he is playing it (up close), after he is done (the close up shot ends), look at the colors again on the SIMON SAYS, they change.

Continuity mistake: As Peter and Lois take Stewie to the hotel, as we first see Peter, he has on a blue suit. The next scene we see him, he has on a black suit. Then, as they get called in the room, he has his usual on: green pants and a white shirt.

Other mistake: When Stewie sneaks into his parents' room and attaches the breastfeeding pump to Lois, he places the cups too high on her chest for them to be on her nipples. You can see this, especially after he removes the cups.

Deliberate mistake: In season 4 episode 7, 'Brian the bachelor'. Cleveland is sitting in a chair in a waiting room and is getting really nervous. Peter tries to help him by tying him to a chair and when that doesn't work, he takes off all of their clothes. Peter ties Cleveland's hands to the arms of the chair and then takes Cleveland's clothes off. He couldn't have taken the shirt off while Cleveland's hands were tied to something without untying him or ripping the shirt, which he didn't do.

Continuity mistake: When Lois and Peter are in bed prior to the Raisin Bran spoof, in one frame Peter is not wearing glasses, the next close-up he is, and in the next frame he is again without glasses.

Continuity mistake: In the scene where Stewie is eating chocolate cake, he shoves his head in it and covers himself in cake. However when Peter walks in after having liposuction, all the cake has disappeared and Stewie is now completely clean. The bowl of grapes on the table is also gone.

Continuity mistake: When we first see the English guy in his car, his crates of goods are stacked askew in the back seat. After Peter's crew shoot the car several times and the car is half-wrecked, the boxes are suddenly neatly packed into the seats. Moments later, we see the boxes piled randomly again. This change happens a couple more times before the scene is over.

Continuity mistake: When Stewie is trying to get a drink from Brian, there are two alcohol bottles on top of the table. But one is gone for two shots, then comes back. Also the bottles change from closer to father.

Audio problem: When Peter introduces the pope to his friends at work, and he is saying "Remember when we got that stripper for Charlie and it turned out to be his son? I think this is gonna top it" or something along those lines), Peter's mouth very obviously does not sync up with the words being said.

Continuity mistake: When Peter is calling for people to fight Lois, he is standing next to a sign that says "Fight the ass kicking housewife" and has metal rings at the top. When it moves to a closer shot, a hyphen has appeared between "ass" and "kicking". Then, after the space where the commercial break would have been, the sign now says "$10.00" and there are no metal rings. Finally, in the next shot, the sign says "Fight the..." and has metal rings on top.

Continuity mistake: After getting the uranium, Stewie places it in the time pad and then puts the pad in his jacket pocket. After being confronted by Hitler who promises to spare them if they sing a musical number, Mort interrupts them, and it's seen that he is now standing on the time pad.

Audio problem: When Peter goes down to the basement, the Pawtucket Patriot guy appears and Peter thinks he's coming on to him. He says, "Listen, I don't swing that way, pal. I got a date with my female wife, I just came down to get some beers." However, his lips very obviously do not sync up with those words.

Continuity mistake: In the flashback when Peter fights Ernie the Giant Chicken, Peter gets knocked off the top of an eighteen wheeler and grabs the second rung at the bottom of the truck's ladder. But when the truck driver sees the pair in his side view mirror, Peter is hanging off the top of the ladder.

Lois: Hello?Peter: I can't take the trash out today, I'm working late at the office.Lois: The caller ID says you're calling from the kitchen. In fact I can see you.Peter: [Edging sideways.] OK, can you see me now?Lois: No.Peter: Now I am at the office.