NETosis: the underlying mechanisms

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NETosis: the underlying mechanisms

Jacobino, S.R.

(2011) Faculty of Medicine Theses

(Master thesis)

Abstract

Neutrophil extracellular traps (NETs) are crucial for the host innate immune response against invading pathogens. Composed of potent antimicrobial effectors embedded in a DNA backbone, they trap, disarm and kill a wide variety of pathogens. Although NETs have been recognized as a novel microbial killing strategy, there remains a gap ... read more in the understanding of the mechanisms regulating their formation. Recently, the process of NET formation was described as a new paradigm in cell death programs, which was later termed NETosis. This review summarizes recent progress made in the identification of the mechanisms underlying NETosis. In addition, attention is given to the role of NETs in health and disease and to mechanisms certain leading bacteria have developed to counteract the effects of NETs. show less

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