3 Detoxification PathwaysDrainage vs. eliminationDrainage- from the organ/matrix to the circulation systemElimination- From the circulation system out via the GI Tract, urination, breathing (lungs), skin, & other excretions

6 Detox Principles & PhilosophyUnderstand the difference between drainage and elimination and how to support bothInitial preparation - assessment, strategy & planning with emphasis on seasonal timingUtilize appropriate support structure and toolsConstruct realistic goals and proceed slowly

14 EDTA, DMSA & DMPS Used for ProvocationSometimes called a "challenge" or "provoked" heavy metals test.The ability of EDTA, DMSA or DMPS to mobilize heavy metals stored in body tissues (& therefore not typically present in the circulation) increases the excretion of heavy metals in the urine, leading to more accurate identification of total heavy metal toxicology than hair or blood tests alone.This must be performed by trained medical practitioners, with timed urine collections sent out to a specialized laboratory for analysis.

16 Natural ChelatorsMore recently natural chelating agents have also been discovered, such as the use of pectins after the Chernobyl disaster in 1986.Includes polyuronide soluble fibers (Modified Citrus Pectin & kelp alginates), Vitamin C, natural thiol compounds & sulfur containing amino acids, kelp derived alginates & even herbs such as cilantro/coriander (Coriandrum sativum).These have properties that bind with metallic ions so that the ion is held by several chemical bonds. This renders it much less chemically reactive, producing a complex that is water soluble allowing it to be excreted harmlessly by the body.

17 Natural Chelation is Significantly SaferAlpha Lipoic Acid (ALA): Rare cases of allergic reaction. Other possible side effects include headache, muscle cramps, & a feeling of “pins & needles” in the body. Not to be used in initial state of chelation.Vitamin C: Rare cases of gastrointestinal complaints. These side effects normally stop as soon as high potency intake is reduced or stopped.Modified Citrus Pectin: No known adverse effects other than occasional loose stools.Alginates: No documented adverse effects

18 Modified Citrus Pectin (MCP) in Chelation and DetoxificationClinical data indicates that MCP functions as a gentle chelator of heavy metals.The detoxification properties have been confirmed in clinical trials & case studies.MCP has shown in clinical studies to increase the urinary excretion of toxic metals such as lead, cadmium, arsenic & mercury.Long-term use of this gentle safe chelator could effectively reduce the body burden as shown in a clinical trial.The ability of MCP and modified Alginates to remove heavy metals & environmental toxins on an ongoing basis has been shown to be of significant clinical benefit in multiple case studies.

19 Chemical Properties of Alginates & PectinA class of complex polysaccharide compounds known as polyuronides. Polyuronides are long chains of repeating sugar acid groups such as galacturonic acid (pectin) or mannuronic & guluronic acid (alginates). Polyuronides are proven chelators of toxic metals, pesticides & herbicides, and have been used in humans exposed to lead & radioactive metals as well as in the clean-up of environmental pollution for over 40 years.

20 Chelation “Egg Box” TheoryMetal Complex FormationPolyuronides form stacks in solution in what is known as an “egg box” structure. Each pocket of the “egg carton” contains a positively charged ion to balance the negatively charged chains. Normally the positive ions are sodium & potassium. However, toxic metals especially lead, mercury, cadmium, & radioactive metals have a higher affinity for polyuronides than the essential ions like calcium, magnesium, & potassium. Toxic metal ions become trapped in the “egg box” structure & are eliminated from the body.

21 Stage I DetoxificationDuring the first stage of detoxification, avoid introducing agents that can penetrate into the tissues & bind heavy metals to them. The concern is that they can pull heavy metals including mercury from the circulation into the tissues, especially the brain.

22 Stage I Detoxification ContinuedFirst chelate using MCP, or Modified Citrus Pectin/Alginate complex to slowly reduce the overall heavy metal burden on the tissue level for 2-4 weeks.During the initial chelation stage, higher dosages of such a combination are needed.For maintenance & long term prevention, lower dosages are sufficient. Due to ongoing exposure to heavy metals such as lead & mercury, there is great benefit to using such a preparation on a long term basis.Modified Citrus Pectin/Alginate complex provides on-going gentle chelation systemically in the blood stream as well as in the digestive tract.

28 Study ConclusionMCP was effective in decreasing the total body burden of Mercury in all subjects.MCP is a promising systemic gentle chelator of heavy metals that can be used on an on going basis.Percent Reduction in Mercury from Baseline10 months4.5 months4 months6 months6.5 monthsMCP Intervention Individual Results

30 Lead in 24 Hour Blood Serum1020304050601234567P Value =Figure 1 Blood serum lead concentration (ug/dL) measured in blood serum by GFAAS before (Blue) and after (Red) Modified Citrus Pectin treatment (5 grams three times daily) in 7 hospitalized children 5-12 years of age. No side effect reported.

31 Lead in 24 Hour Urine Excretion204060801001201401234567P Value =Figure 2 Lead levels (µg/dL) measured in 24-hour urine excretion by GRAS before (Blue) and after (Yellow) Modified Citrus Pectin treatment (5 grams three times daily) in 7 hospitalized children 5-12 years of age. No side effects reported.

32 Stage II DetoxificationSupport heavy metal discharge and purge heavy metals while the body is going through a detoxification process. We can foster this process by:Removal & excretion of heavy metals from the tissue.Preventing re-absorption of heavy metals secreted via the bile to the gut.Binding circulating heavy metals, neutralizing & preventing re-absorption in the gut.Aiding the liver & the detoxifying enzymes in the body, support drainage & elimination.Supporting the body’s energy/vitality/strength to allow the body to “follow through” & successfully chelate the heavy metals.Supporting tissues where the chelation process can create side effects, such as the brain.

33 Stage II Supplementation: Detox CompletePoly botanical/thiols/nutrient formula is the second stage in a unique, two-part integrated detoxification system that broadens the gentle systemic chelation process.Designed as a complimentary formula to be used after 2-4 weeks of gentle chelation with Modified Citrus Pectin/Alginate complex.Poly botanical/thiols/nutrient formula supports detoxification by addressing multiple facets of chronic heavy metal toxicity.It fosters systemic chelation by providing a comprehensive combination of vitamins, nutrients & herbs that support detoxification from the tissues & organs and aids in liver detoxification, promoting elimination through both the bile/intestines & the urinary tract.

45 The Association of Dental Plaque with Cancer Mortality in SwedenSoder B, Yakob M, et al. Dept. of Dental Medicine, Karolinska Institutet, Huddinge, Sweden BMJ Open 2012;2;e doi: /bmjopenObjectives: To study whether the amount of dental plaque, which indicates poor oral hygiene and is a potential source of oral infections, correlates with premature death from cancer.Methods: Prospective cohort study randomly selected healthy young Swedes followed from 1985 to 2009.

46 The Association of Dental Plaque with Cancer Mortality in SwedenSoder B, Yakob M, et al. Dept. of Dental Medicine, Karolinska Institutet, Huddinge, Sweden BMJ Open 2012;2;e doi: /bmjopenResults: 4.2% of participants died during the study. Amount of dental plaque between those who died and those who survived was statistically significant with 1.79 times the overall risk of death via scattered malignancies in men and breast cancer in majority of women.Conclusion: Increased amount of dental plaque may be associated with increased cancer mortality. Further studies are warranted.

49 A Review of the Relationship Between Tooth Loss, Periodontal Disease, and CancerMeyer M, et al. Harvard School of Public Health Dept. of Epidemiology, Boston, MA. USA Cancer Causes Control :Objectives: A review of 18 published studies demonstrating relationships and possible mechanisms of action between tooth loss, periodontal disease and various cancers. Controlled for smoking, demographics and other possible confounding factors.