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I just discovered the Infinite Ammo Podcast recently, and it quickly became one of my favorites. It doesn't get too technical, but there's a lot of really meaty, honest conversations about the design process and the challenges facing smaller indie teams. Really great insight into the indie game dev community.
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mrohlfAug 11 '11 at 22:58

Another Castle is a game design podcast that focuses on the game development scene in the New York area. Sometime the audio isn't that good (they record a lot in restaurants) but the interviewees are always interesting.

Hey guys I am the creator of "The Game Developer's Radio" want to say thanks for linking to my show! It's been on a bit of a Hiatus for a while, but I finally released a new episode :-D http://bit.ly/qq46WP And will be releasing plenty more, very soon!

Great lists here.. Glad to see www.industrybroadcast.com plugged. Back recording articles again after a nice almost year long hiatus. The podcast is certainly a bit more dry and serious as the topics covered can get insanely indepth, theoretical and technical.

Outside of my biased opinion though I have to say A Life Well Wasted tops my list, not just in this genre but of any podcast I have ever listened to.. It is absolutely and purely brilliant