We're committed to providing you with the very best cancer care, and your safety continues to be a top priority. With this in mind, we’ve put in place many new procedures, including a limited visitor policy and are not allowing patients to have people with them during appointments. This is just one more way of ensuring your safety and that of our staff. Read more

Purpose

Some patients with acute myeloid leukemia (AML) have a specific genetic mutation (abnormality) in their leukemia cells called the FLT3/ITD mutation. Patients with this mutation are more likely to experience a relapse of their disease after standard chemotherapy. Having an allogeneic stem cell transplant (receiving healthy stem cells from a matched donor) is recommended after chemotherapy in these patients to reduce the risk of the leukemia coming back.

In this study, researchers want to see if taking the drug gilteritinib lowers the risk of AML recurrence after an allogeneic stem cell transplant. Gilteritinib (also called ASP2215) may help kill leukemia cells by blocking the pathways that FLT3-positive cells use to grow and divide. Patients will be randomly assigned to receive gilteritinib or a placebo (inactive pill). Gilteritinib is taken orally (by mouth).

Eligibility

To be eligible for this study, patients must meet several criteria, including but not limited to the following:

Patients must have FLT3-ITD-mutated AML in first remission and be eligible for stem cell transplantation.

Patients must have a source of donated stem cells (related or unrelated donor or umbilical cord blood).

Patients may not have received more than two cycles of induction chemotherapy to achieve first remission.

This study is for patients age 18 and older.

For more information and to inquire about eligibility for this study, please contact Dr. Esperanza Papadopoulos at 212-639-8276.