The promise came in a joint appearance by Department of Homeland Security
Secretary Janet Napolitano and Health and Human Services Secretary Kathleen
Sebelius, held to soothe U.S. frustrations over the slow rollout of the H1N1
swine flu vaccine program.

H1N1 swine flu continues to sweep the nation -- and so do complaints about
long lines and insufficient vaccine supplies.

"This is not a situation that calls for panic," Napolitano said. "The
protection of the country as a whole is under way. ... The thing we have to do
now is work our way through the sequence of events. That sequence is that
states have opened 150,000 vaccination sites, and every day that goes by, more
vaccine is being made available."

Napolitano and Sebelius said they understood Americans' frustrations over
the slower-than-predicted availability of H1N1 swine flu vaccine. But they
defended the decision to ship vaccine doses as soon as they became available,
rather than waiting for production of enough vaccine to ensure a smooth-running
program.

Sebelius noted that the original plan had been to start the vaccination
program around Oct. 15. But advisory panels made up of nongovernment flu and
infectious-disease experts urged the administration to release H1N1 swine flu
vaccine as soon as possible.

"We made the decision when some early vaccine became available to push it
out the door, even though it was in much smaller quantities than we had
anticipated," Sebelius said. "Since Oct. 5, when we began vaccinating
Americans, more than 23 million doses have become available and more is being
processed every day. ... That pace is picking up. The early problems and
production challenges have been fixed."

Those problems include:

Early "seed" viruses did not grow well on hens' eggs.

The yield of viral antigen per egg -- the key ingredient in a vaccine --
was lower than expected.

Glitches plagued new "fill and finish" production lines manufacturers had
added to speed vaccine production.

Each state has a different plan for how to provide vaccine to its citizens.
Some states were less prepared than others.

Such problems are the rule, and not the exception, for a biologic product
that is made via a 50-year-old process.

"There is no question that production started more slowly than anyone would
have liked, but frankly, many things that could have gone wrong actually have
gone right," Sebelius said. "We want folks to remember that a safe and
effective vaccine was the primary goal, and we have arrived at that end goal.
The supply to states is steadily growing."