Wisniewski was called up early to the Blackhawks in the 2006–07 season and stuck with the team. However, he tore his anterior cruciate ligament (ACL) during the first period in a game against the Los Angeles Kings on March 5, 2007, and was placed on injured reserve, missing the rest of the season.

In the 2009–10 season, Wisniewski entrenched himself in the Ducks' defense corps and scored a career-high 30 points in 69 games. On March 17, 2010, in a game against former team, the Blackhawks, Wisniewski delivered a retaliation hit to Brent Seabrook, his former teammate and good friend, driving his head against the glass. Wisniewski received an eight-game suspension for the hit; the last player to receive a suspension of that length was former Duck Chris Pronger.[3]

At the beginning of the 2010–11 season, on October 12, 2010, Wisniewski was suspended for two games for making an obscene gesture towards Sean Avery.[5]

On December 28, 2010, Wisniewski was traded to the Montreal Canadiens for second-round pick in the 2011 Draft and conditional fifth round pick in 2012.[6] He scored seven goals to go with 23 assists in 43 games with the Canadiens, as well as two assists in six playoff games.

On June 29, 2011, Wisniewski's rights were traded to the Columbus Blue Jackets in exchange for a conditional seventh-round draft pick in 2012; the pick would become a fifth-rounder if Columbus signed him.[7] He subsequently signed a six-year, $33 million contract with the Blue Jackets on July 1, 2011.[8]

On September 26, 2011, Wisniewski was suspended for the remainder of the pre-season and eight regular season games by the NHL for a hit to the head of Minnesota Wild forward Cal Clutterbuck on September 23 after the end of regulation.[9] In an injury-shortened 2011–12 season, Wisniewski appeared in 48 games with Columbus, scoring six goals along with 21 assists as the Blue Jackets finished well out of the playoff hunt.

Wisniewski would again suffer another season plagued by injuries in the lockout-shortened 2012–13 season, producing 14 points in 30 games with the Blue Jackets. However, in 2013–14, he scored seven goals and a career-high 51 point in 75 games, tied with the St. Louis Blues' Alex Pietrangelo for ninth in points among NHL defensemen, helping the Blue Jackets clinch their first playoff berth since 2009.[10]

On March 2, 2015, Wisniewski was traded by the Blue Jackets to the Anaheim Ducks, along with a 2015 third-round pick, in exchange for Rene Bourque, William Karlsson and a 2015 second-round pick, marking the beginning of his second term with the Ducks.[11]

On June 27, 2015, the second day of the 2015 NHL Entry Draft, Wisniewski was traded to the Carolina Hurricanes In exchange for Anton Khudobin.[12] In the 2015–16 season, in his first game with the Hurricanes on opening night, Wisniewski suffered a tear to his left ACL after playing in just 47 seconds, which effectively ended his season.[13] Wisniewski's brief shift with the Hurricanes would be his last, for in the off-season and nearing a return to full health, he was bought out from the final year of his contract on June 30, 2016.[14]

On August 10, 2016, the Lightning signed Wisniewski to a professional tryout agreement. On October 2, 2016, as part of the Lightning's roster reduction, the Lightning announced that it had released Wisniewski from his tryout agreement.[15]

Wisniewski is married to Nicole Wisniewski and has two daughters, Jamie and Sadie. Wisniewski started a clothing line called WizWear. According to Wisniewski, "I always like to dress nice and have my own style. We support the USO of Illinois, the families of fallen soldiers. I wanted to do something a little bit different to set up for a charity than a golf tournament or bowling event. It's something I can have a little bit of fun with also." Both of his grandfathers fought in World War II.[21]

Wisniewski is the nephew of former NHL player and coach Billy Dea.[22]

He is an accomplished amateur golfer and has won a club championship at Jack Nicklaus' Muirfield Village Golf Club.