..Because pedigree implementations of the gamete competition model can accommodate dominant as well as codominant markers, they circumvent the phase problem by including all possible phases weighted by their estimated frequencies...

..Our findings suggest that modulation of MYLIP activity can affect LDL-C levels and that pharmacologic inhibition of MYLIP activity might be a useful strategy in the treatment of dyslipidemia and ASCVD...

Prioritizing GWAS results: A review of statistical methods and recommendations for their application

..Under these conditions, the exact test is clearly preferred over the asymptotic test. Under all other conditions that we tested, the user can safely choose either the exact test or the asymptotic test...

Extinction models for cancer stem cell therapy

Mary SehlDepartment of Biomathematics, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USAMath Biosci 234:132-46. 2011

..The current cancer models demonstrate the virtue of attacking the same quantitative questions from a variety of modeling, mathematical, and computational perspectives...

Sex steroid metabolism polymorphisms and mammographic density in pre- and early perimenopausal women

..Less is known about its feasibility to identify genes for complex traits. We used exome sequencing to search for rare variants responsible for a complex trait, low levels of serum high-density lipoprotein cholesterol (HDL-C)...

Does history repeat itself? Wavelets and the phylodynamics of influenza A

Jennifer A TomDepartment of Biostatistics, School of Public Health, University of California, Los Angeles, CA, USAMol Biol Evol 29:1367-77. 2012

..We also address hypotheses regarding intersegment dynamics within a formal statistical framework that accounts for correlation between segment-specific parameters...

..02). The MMP2 rs2287074 A allele may be associated with a lower likelihood of ARM in older Caucasian women, particularly those who have never used hormone therapy. The role of MMP2 rs2287074 in ARM should be further elucidated...

Applications of codon and rate variation models in molecular phylogeny

..We anticipate that in conjunction with experimental observation of cancer stem cell killing rates, our results will be useful in screening targeted therapies for both hematologic and solid tumor malignancies...

..Of course, each pedigree of interest will have some core people who must be retained. The described algorithm retains just enough of the pedigree to maintain the proper relationships among the core people...

Mary E SehlDivisions of Hematology and Oncology and Geriatrics, Department of Medicine, David Geffen School of Medicine at University of California at Los Angeles, USAClin Cancer Res 15:2192-203. 2009

..DNA damage recognition and repair play a major role in risk for breast cancer. We investigated 104 single nucleotide polymorphisms (SNP) in 17 genes whose protein products are involved in double-stranded break repair (DSBR)...

Association screening of common and rare genetic variants by penalized regression

..We first examine the evolutionary history of multiple serotypes of dengue virus in the Americas to showcase our method. Additionally, we explore an application to intrahost HIV evolution across multiple patients...

..We report analyses examining the main effects of functional polymorphisms within dopamine-modulating genes, as well as their interactive effects with disease severity, upon neurocognitive functioning in HIV+ adults...

Replication of GWAS associations for GAK and MAPT in Parkinson's disease

..14) did not replicate in our study population. While MAPT has been considered a PD candidate gene and has been observed in association with PD in other GWAS, GAK is a new candidate for investigation in future studies...

Epigenetic predictor of age

Sven BocklandtDepartment of Human Genetics, University of California Los Angeles, Los Angeles, California, United States of AmericaPLoS ONE 6:e14821. 2011

Shilpa NarayanDepartment of Epidemiology, Fielding School of Public Health, UCLA, Los Angeles, CA, USA, Departments of Human Genetics and Biomathematics, David Geffen School of Medicine, and Department of Biostatistics, Fielding School of Public Health, UCLA, Los Angeles, CA, USA and Department of Neurology, School of Medicine, UCLA, Los Angeles, CA, USAInt J Epidemiol 42:1476-85. 2013

..Here we investigate whether long-term use of household pesticides, especially those containing OPs, increases the odds of PD...

Ganka NikolovaDepartment of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USAGenetics 179:419-27. 2008

..We conclude that a chromosome 11 locus derived from 129Sl/SvImJ essentially protects against sex reversal in XYPOS mice. A number of genes located in this chromosome 11 region are discussed as potential candidates...