ABSTRACT: An experiment type
of research was conducted to find out the effects of propolis extract dosage on
the cellular immune system of Rattus norvegicus. The administration per oral of
propolis extract was 40 days and given at different levels of dosage for each group : 9 mg/day (1st group); 12 mg/day (2nd group)
and 15 mg/day (3rd group). The results showed that the average level of
leucocytes in the control group
(untreated one) was 3883,33 ± 1563,86 cell/mm3, which comprised of 75,17
± 4,36 % lymphocytes, 6,67 ± 2,66 %
monocytes and 18,17 ± 5,12 % granulocyte. The average level of leucocytes of
the first group was 3616,67 ± 1085,20 cell/ mm3 (contained 75,67 ± 4,50 %
lymphocytes, 10,50 ± 5,21 % monocytes and 13,83 ± 2,14 % granulocytes); The second one was 4100 ± 551,36 cell/ mm3
leucocytes (containing 67,33 ± 8,57 % lymphocytes, 3,50 ± 1,38 % monocytes and
25 ± 5,48 % granulocytes), and the third one was 4383,33 ± 1121,46 cell/ mm3
which contained 70 ± 5,10 % lymphocytes, 1,83 ± 0,41 % monocytes and 28,17 ±
5,19 % granulocytes. It may be concluded that the propolis extract could
increase the number of leucocytes that influential to response cellular immune
system of Rattus norvegicus. The increase of propolis dosage concentration
significantly not related each other because the lymphocytes and monocytes cell
have a similar correlation.