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This project has been funded in part with Federal funds from the National Cancer Institute of the National Institutes of Health (Contract No. N01-C0-37117 and R01CA124427-01). M.J.S., E.R., and S.N.B. are members of the Moores UCSD Cancer Center and the UCSD NanoTUMOR Center under which this research was conducted and partially supported by NIH Grant U54 CA 119335. J.P. thanks the Korea Science and Engineering Foundation (KOSEF) for a Graduate Study Abroad Scholarship. The authors thank Todd Sponholtz and Dr. Ralph Weissleder for use of the NIR fluorescence-imaging system, and Dr. Edward Monosov for assistance with TEM analysis.

Abstract

The synthesis, in vitro, and in vivo behavior of tumor-homing magnetic nanoworms (NW) are described. The particles consist of a chainlike aggregation of iron oxide (IO) cores in a dextran coating. When conjugated with a tumor-targeting peptide, they interact more effectively with a tumor-based target in vitro relative to spherical nanoparticles. Untargeted NW display similar in vivo circulation times and enhanced passive accumulation in mouse xenograft tumors relative to untargeted spherical IO nanoparticles.

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