Mouse Anti-Human Cathepsin E

Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.

Stability and Storage

Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20 °C for at least for six months without detectable loss of activity.

Preparation

This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with human recombinant protein of Cathepsin-E.

Antigen

recombinant human Cathepsin-E

Application

WB

Synonyms

CTSE; CATE

Description

Cathepsin E is an intracellular aspartic protease of the pepsin family. Unlike Cathepsin D, another member of the same family and a lysosomal protease with relatively ubiquitous distribution, Cathepsin E is not a lysosomal enzyme and has a limited cell and tissue distribution. However, both Cathepsin D and E play an important role in the degradation of proteins, the generation of bioactive proteins, and antigen processing. Both enzymes are efficient in cleaving Swedish mutant of amyloid precursor protein (APP) at the β site but show almost no reactivity with wildtype APP. Human Cathepsin E is synthesized as a precursor protein, consisting of a signal peptide (aa 1-17), a propeptide (aa 18-53), and a mature chain (aa 54-396).