2D Multi-Slice Quantitative Myelin
Water Imaging at 3T

Myelin water fraction (MWF) provides a direct
indicator of myelin structure and component change due to white matter
diseases. Conventionally, the data acquisition time for generating a MWF map
of a single slice takes about 25 minutes. In this study, we proposed a 2D
multi-slice acquisition scheme with much higher efficiency and capturing the
small contribution of the myelin-water signal. This acquisition scheme could
cover most of the brain volume in less than 12 minutes. We also provided a
weighted regularized nonnegative least squares (wrNNLS) algorithm to generate
reliable parametric maps.