ACPred is a webserver for the prediction of adenylyl cyclase functional centers (ACCs) from amino acid sequence. ACC is a novel class of functional centers typically consisting of short 14 amino acids and is found in complex multi-domain proteins. They are different from canonical AC domains hence ACPred is not valid for the prediction of such domains as well as transmembrane regions.

Instructions:
The software takes a single or multiple amino acid sequence and returns predicted ACCs each accompanied by ACC values 0-1, where 1 is closest to the mean of experimentally validated ACCs.

Please enter single letter amino acid codes in FASTA format and select if co-factor binding (Mg2+/Mn2+) is required. The amino acid implicated in co-factor binding is found at 0-3 positions downstream of the ACC.