BACKGROUND
A more accurate means of prognostication in breast cancer will improve the selection of patients for adjuvant systemic therapy.
METHODS
Using microarray analysis to evaluate our previously established 70-gene prognosis profile, we classified a series of 295 consecutive patients with primary breast carcinomas as having a gene-expression… (More)

BACKGROUND
A 70-gene tumor expression profile was established as a powerful predictor of disease outcome in young breast cancer patients. This profile, however, was generated on microarrays containing 25,000 60-mer oligonucleotides that are not designed for processing of many samples on a routine basis.
RESULTS
To facilitate its use in a diagnostic… (More)

OBJECTIVES
To develop a graph of semi-quantitative Biolfa(®) olfactory test data and to assess a method of mathematical measurement of the gap between odor perception and identification thresholds.
PATIENTS AND METHODS
The semi-quantitative Biolfa(®) olfaction test comprises eight smells, each diluted in four increasing concentrations. Perception and… (More)

BACKGROUND
Microarray diagnostics of tumour samples is based on measurement of prognostic and/or predictive gene expression profiles. Typically, diagnostic profiles have been developed using bulk tumour samples with a sufficient amount of tumour cells (usually >50%). Consequentially, a diagnostic results depends on the minimal percentage of tumour cells… (More)

This paper describes a bi-specific antibody, which was called BIS20x3. It retargets CD3varepsilon-positive cells (T-cells) to CD20-positive cells and was obtained by hybrid-hybridoma fusion. BIS20x3 could be isolated readily from quadroma culture supernatant and retained all the signalling characteristics associated with both of its chains. Cross-linking of… (More)