I think cPanel/WHM is the best for web hosting. It seems to be the most reliable and most supported. If you don't like it, than I think you should go with DirectAdmin as a second. Personally, I'd prefer using cPanel.

I'd go for cPanel. I would say pretty much all webmasters know how to use it, it's simple, has loads of features and combines them well. The support you get from cPanel is very good, tickets are answered very promptly too. It's paid software, but it does the job well.

HC8 is a complete web hosting automation control panel which is designed for web hosts to experience infinite hosting possibilities in cluster environment. It enables web hosting companies to manage all their servers both Windows & Linux through centralized interface. Diversify web hosting business with HC8 enterprise module by adding multiple mail servers within a cluster and offering Microsoft Exchange 2007/2010 & SharePoint, Dynamics CRM and OCS hosting.

Installation of HC8 requires you to do first install on database server. This database server must have Windows OS and can just be a standalone database server or can have other roles (Web, Mail, DNS) as well depending on your requirements. The only pre-requisites of HC8 are MS-SQL, IIS and FTP server. These must be installed prior to HC8 installation. However rest of the applications like DNS, Mail etc can be installed and configured easily after HC8 installation.

As I have noticed from many hosting companies " CPanel / WHM - http://www.cpanel.net/ " is the most commonly used Cpanel out there, and I have been using it as well for almost a year now and I can say its very easy and reliable to use.

The control panel is an application designed to control and manage your Web site hosting. Through the control panel you can manage activities such as email creation, opening of your FTP accounts, statistics reports, etc. Though the control panel alone cannot be used as a yardstick to judge the quality of a Web hosting service, it is a vital aspect.