ELISA (1:500-1:2,000)Immunohistochemistry (frozen sections, 1:100-1:300)Suggested dilutions/conditions may not be available for all applications.Optimal conditions must be determined individually for each application.

Formulation:

Liquid. Ascites.

Handling:

Avoid freeze/thaw cycles.

Shipping:

Shipped on Blue Ice

Short Term Storage:

+4°C

Long Term Storage:

-20°C

Scientific Background:

The laminins are a family of glycoproteins that provide an integral part of the structural scaffolding of basement membranes in almost every tissue. Each laminin is a heterotrimer assembled from α, β and γ chain subunits, secreted and incorporated into cell-associated extracellular matrices. The laminins can self-assemble, bind to other matrix macromolecules, and have unique and shared cell interactions mediated by integrins, dystroglycans, and other receptors. Through these interactions, laminins critically contribute to cell differentiation, cell shape and movement, maintenance of tissue phenotypes and promotion of tissue survival.