Francis Locke (October 31, 1776 - January 8, 1823) was a U.S. senator from the state of North Carolina. Formerly a judge on the Supreme Court of North Carolina, he was elected to the Senate in 1814 to fill a vacancy caused by the resignation of David Stone, but resigned in 1815, before he could qualify.

Preceded by: David Stone Senators from North Carolina Succeeded by: Nathaniel Macon Served alongside: James Turner

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