Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )

Length:

123

Sequences:

6438

Seq/Len:

52.34

HH_delta:

0.872 (20Jul13)

GREMLIN Results:
Residue pairs sorted by strength in covariance:Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

i

j

Raw Score

Scaled Score

32_L

99_F

1.41595

3.451

98_P

101_R

1.15649

2.818

71_F

105_A

0.95393

2.325

24_T

111_L

0.93168

2.270

28_V

107_L

0.90144

2.197

20_F

115_I

0.9012

2.196

15_G

18_L

0.89017

2.169

20_F

118_V

0.81571

1.988

63_E

67_Q

0.79274

1.932

32_L

103_F

0.7465

1.819

69_Y

72_W

0.73155

1.783

71_F

101_R

0.71419

1.740

38_G

93_G

0.7139

1.740

15_G

19_G

0.70083

1.708

36_L

40_Y

0.69301

1.689

100_R

104_L

0.6804

1.658

99_F

103_F

0.67358

1.641

16_P

20_F

0.65145

1.588

18_L

22_I

0.64899

1.582

75_F

108_I

0.64687

1.576

36_L

99_F

0.64131

1.563

38_G

94_I

0.61547

1.500

51_R

54_K

0.6026

1.469

23_A

114_T

0.60055

1.464

78_R

106_S

0.59414

1.448

72_W

76_L

0.58942

1.436

34_A

90_Y

0.5842

1.424

39_R

96_R

0.5651

1.377

43_R

63_E

0.56072

1.366

22_I

26_G

0.55228

1.346

35_Y

102_F

0.53417

1.302

24_T

114_T

0.53188

1.296

77_S

88_V

0.5082

1.238

11_G

121_G

0.50639

1.234

18_L

21_L

0.49213

1.199

105_A

109_G

0.4903

1.195

28_V

103_F

0.48652

1.186

17_W

20_F

0.48479

1.181

79_F

112_P

0.48097

1.172

102_F

106_S

0.48008

1.170

32_L

36_L

0.46355

1.130

31_S

106_S

0.46305

1.128

64_R

67_Q

0.46171

1.125

7_L

11_G

0.45496

1.109

27_A

110_K

0.44888

1.094

112_P

115_I

0.44782

1.091

35_Y

99_F

0.44349

1.081

10_A

19_G

0.43814

1.068

17_W

21_L

0.43372

1.057

24_T

28_V

0.43295

1.055

92_A

97_M

0.42974

1.047

85_F

110_K

0.42827

1.044

55_R

58_R

0.42788

1.043

49_K

52_K

0.42589

1.038

20_F

24_T

0.42309

1.031

63_E

95_T

0.42214

1.029

85_F

113_W

0.41851

1.020

16_P

119_L

0.41848

1.020

28_V

110_K

0.41203

1.004

114_T

118_V

0.41136

1.002

110_K

113_W

0.40714

0.992

19_G

118_V

0.40633

0.990

21_L

25_L

0.40486

0.987

66_F

70_G

0.39993

0.975

35_Y

39_R

0.39628

0.966

78_R

110_K

0.39498

0.963

86_D

89_N

0.39352

0.959

24_T

107_L

0.39074

0.952

103_F

107_L

0.38924

0.949

11_G

19_G

0.38851

0.947

65_W

73_V

0.38739

0.944

74_L

105_A

0.38723

0.944

101_R

104_L

0.38542

0.939

4_S

117_Y

0.38055

0.927

108_I

111_L

0.37772

0.920

17_W

119_L

0.37651

0.918

10_A

14_F

0.3732

0.909

36_L

39_R

0.37176

0.906

9_A

12_A

0.36955

0.901

34_A

89_N

0.36879

0.899

101_R

105_A

0.36735

0.895

7_L

23_A

0.36629

0.893

23_A

118_V

0.36495

0.889

35_Y

38_G

0.36432

0.888

50_L

53_K

0.36121

0.880

45_R

48_R

0.36004

0.877

31_S

78_R

0.35278

0.860

110_K

114_T

0.34566

0.842

33_L

36_L

0.3445

0.840

75_F

105_A

0.34286

0.836

71_F

97_M

0.34272

0.835

104_L

108_I

0.33952

0.827

73_V

77_S

0.33806

0.824

106_S

110_K

0.33638

0.820

37_L

41_F

0.33256

0.810

78_R

89_N

0.33255

0.810

42_G

45_R

0.33253

0.810

78_R

85_F

0.33144

0.808

21_L

24_T

0.32705

0.797

55_R

87_V

0.3262

0.795

4_S

7_L

0.32411

0.790

31_S

89_N

0.32062

0.781

40_Y

44_R

0.31938

0.778

22_I

25_L

0.31931

0.778

30_G

34_A

0.31829

0.776

14_F

19_G

0.31807

0.775

65_W

68_K

0.31541

0.769

20_F

119_L

0.31414

0.766

78_R

109_G

0.31368

0.764

54_K

58_R

0.31013

0.756

64_R

68_K

0.30862

0.752

9_A

13_L

0.30562

0.745

12_A

121_G

0.30539

0.744

66_F

92_A

0.30351

0.740

44_R

47_R

0.29786

0.726

88_V

92_A

0.29758

0.725

16_P

118_V

0.29745

0.725

48_R

51_R

0.29613

0.722

75_F

112_P

0.29564

0.720

4_S

85_F

0.29537

0.720

7_L

114_T

0.29449

0.718

53_K

57_K

0.29404

0.717

104_L

107_L

0.29393

0.716

115_I

119_L

0.29364

0.716

10_A

23_A

0.29356

0.715

71_F

104_L

0.29302

0.714

24_T

110_K

0.29261

0.713

77_S

81_P

0.29041

0.708

100_R

103_F

0.28987

0.706

45_R

49_K

0.289

0.704

76_L

80_I

0.28835

0.703

49_K

53_K

0.28834

0.703

108_I

112_P

0.28727

0.700

31_S

102_F

0.28673

0.699

42_G

46_L

0.28636

0.698

8_I

120_L

0.2835

0.691

75_F

109_G

0.27849

0.679

44_R

48_R

0.27805

0.678

107_L

111_L

0.27785

0.677

53_K

56_I

0.27623

0.673

42_G

47_R

0.27545

0.671

34_A

82_G

0.27519

0.671

39_R

93_G

0.27424

0.668

89_N

106_S

0.27208

0.663

85_F

106_S

0.27207

0.663

4_S

86_D

0.27047

0.659

47_R

51_R

0.26974

0.657

47_R

54_K

0.26841

0.654

57_K

64_R

0.26804

0.653

77_S

92_A

0.26733

0.651

26_G

30_G

0.26509

0.646

2_P

81_P

0.26466

0.645

11_G

118_V

0.26361

0.642

86_D

110_K

0.26068

0.635

25_L

28_V

0.2604

0.635

79_F

85_F

0.25976

0.633

62_I

65_W

0.25964

0.633

82_G

110_K

0.25902

0.631

47_R

50_L

0.25864

0.630

78_R

82_G

0.25804

0.629

6_L

86_D

0.25792

0.629

29_L

33_L

0.2559

0.624

115_I

118_V

0.25573

0.623

48_R

53_K

0.25424

0.620

5_I

13_L

0.25293

0.616

35_Y

93_G

0.25209

0.614

42_G

93_G

0.25201

0.614

10_A

13_L

0.25124

0.612

49_K

54_K

0.25007

0.609

77_S

109_G

0.24949

0.608

39_R

42_G

0.24833

0.605

73_V

88_V

0.24721

0.602

98_P

103_F

0.24694

0.602

29_L

32_L

0.2461

0.600

Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.