Anti-MKS1 Antibody

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General Information

Product name

Anti-MKS1 Antibody

Short Description

Rabbit polyclonal to MKS1

Description

The protein encoded by this gene localizes to the basal body and is required for formation of the primary cilium in ciliated epithelial cells. Mutations in this gene result in Meckel syndrome type 1 and in Bardet-Biedl syndrome type 13. Multiple transcript variants encoding different isoforms have been found for this gene.

Product Properties

Target

Gene ID

Gene Symbol

Molecular Weight

64.5 kDa

Database Links

Alternative Names

MKS1Meckel syndrome type 1 proteinMKS1

Function

Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes, Involved in centrosome migration to the apical cell surface during early ciliogenesis, Required for ciliary structure and function, including a role in regulating length and appropriate number through modulating centrosome duplication, Required for cell branching morphology.