Activ

Description: NK-1.1 surface antigen, also known as CD161b/CD161c and Ly-55, is encoded by the NKR-P1B/NKR-P1C gen ... more

Description: NK-1.1 surface antigen, also known as CD161b/CD161c and Ly-55, is encoded by the NKR-P1B/NKR-P1C gene. It is expressed on NK cells and NK-T cells in some mouse strains, including C57BL/6, FVB/N, and NZB, but not AKR, BALB/c, CBA/J, C3H, DBA/1, DBA/2, NOD, SJL, and 129. Expression of NKR-P1C antigen has been correlated with lysis of tumor cells in vitro and rejection of bone marrow allografts in vivo. NK-1.1 has also been shown to play a role in NK cell activation, IFN-Î³ production, and cytotoxic granule release. NK-1.1 and DX5 are commonly used as mouse NK cell markers. collapse

Description: CD3Îµ is a 20 kD transmembrane protein, also known as CD3 or T3. It is a member of the Ig superfamil ... more

Description: CD3Îµ is a 20 kD transmembrane protein, also known as CD3 or T3. It is a member of the Ig superfamily and primarily expressed on T cells, NK-T cells, and at different levels on thymocytes during T cell differentiation. CD3Îµ forms a TCR complex by associating with the CD3Î´, Î³ and Î¶ chains, as well as the TCR Î±/Î² or Î³/Î´ chains. CD3 plays a critical role in TCR signal transduction, T cell activation, and antigen recognition by binding the peptide/MHC antigen complex. collapse

Description: CD3Îµ is a 20 kD transmembrane protein, also known as CD3 or T3. It is a member of the Ig superfamil ... more

Description: CD3Îµ is a 20 kD transmembrane protein, also known as CD3 or T3. It is a member of the Ig superfamily and primarily expressed on T cells, NK-T cells, and at different levels on thymocytes during T cell differentiation. CD3Îµ forms a TCR complex by associating with the CD3Î´, Î³ and Î¶ chains, as well as the TCR Î±/Î² or Î³/Î´ chains. CD3 plays a critical role in TCR signal transduction, T cell activation, and antigen recognition by binding the peptide/MHC antigen complex. collapse

Description: CD3Îµ is a 20 kD chain of the CD3/T-cell receptor (TCR) complex which is composed of two CD3Îµ, one ... more

Description: CD3Îµ is a 20 kD chain of the CD3/T-cell receptor (TCR) complex which is composed of two CD3Îµ, one CD3Î³, one CD3Î´, one CD3Î¶ (CD247), and a T-cell receptor (Î±/Î² or Î³/Î´) heterodimer. It is found on all mature T cells, NKT cells, and some thymocytes. CD3, also known as T3, is a member of the immunoglobulin superfamily that plays a role in antigen recognition, signal transduction, and T cell activation. collapse

Description: CD3Îµ is a 20 kD chain of the CD3/T-cell receptor (TCR) complex which is composed of two CD3Îµ, one ... more

Description: CD3Îµ is a 20 kD chain of the CD3/T-cell receptor (TCR) complex which is composed of two CD3Îµ, one CD3Î³, one CD3Î´, one CD3Î¶ (CD247), and a T-cell receptor (Î±/Î² or Î³/Î´) heterodimer. It is found on all mature T cells, NKT cells, and some thymocytes. CD3, also known as T3, is a member of the immunoglobulin superfamily that plays a role in antigen recognition, signal transduction, and T cell activation. collapse

Description: CD180 is a 105 kD type I membrane protein, also known as RP105 or Ly64. It is a member of the toll-l ... more

Description: CD180 is a 105 kD type I membrane protein, also known as RP105 or Ly64. It is a member of the toll-like receptor family consisting of an extracellular leucine-rich repeat (LRR) and a short cytoplasmic tail. It is expressed on most B cells, monocytes/macrophages, and dendritic cells. CD180 associates with MD-1 to form the RP105/MD-1 surface receptor. CD180/MD-1, by working in concert with TLR4, controls B cell recognition and signalling of bacterial LPS. The ligation of RP105 by RP/14 leads to a strong B cell proliferative response, as well as protection from apoptosis induced by radiation or dexamethasone. Interestingly, in some systems, ligation of RP105 leads to Fas-independent apoptosis. collapse

Description: TCR VÎ²13.1 is a variant of the TCR Î² chain. The receptor is complexed with the TCR Î± chain and be ... more

Description: TCR VÎ²13.1 is a variant of the TCR Î² chain. The receptor is complexed with the TCR Î± chain and belongs to the immunoglobulin superfamily. It is expressed on a subset of T cells and some T cell clones. Variability in the Î² chain is generated by VÎ², DÎ², and JÎ² gene rearrangement, while variability in the Î± chain is generated by VÎ± and JÎ± rearrangement. TCR VÎ²13.1 has been shown to be related to antigen recognition and inflammation as well as diseases, such as HIV and multiple sclerosis. collapse

Description: CD28 is a 44 kD disulfide-linked homodimeric type I glycoprotein. It is a member of the immunoglobul ... more

Description: CD28 is a 44 kD disulfide-linked homodimeric type I glycoprotein. It is a member of the immunoglobulin superfamily and is also known as T44 or Tp44. CD28 is expressed on most T lineage cells, NK cell subsets, and plasma cells. CD28 binds both CD80 and CD86 using a highly conserved motif MYPPY in the CDR3-like loop. CD28 is considered a major co-stimulatory molecule, inducing T lymphocyte activation and IL-2 synthesis, and preventing cell death. In vitro studies indicate that ligation of CD28 on T cells by CD80 and CD86 on antigen presenting cells provides a costimulatory signal required for T cell activation and proliferation. collapse

Description: CD28 is a 44 kD disulfide-linked homodimeric type I glycoprotein. It is a member of the immunoglobul ... more

Description: CD28 is a 44 kD disulfide-linked homodimeric type I glycoprotein. It is a member of the immunoglobulin superfamily and is also known as T44 or Tp44. CD28 is expressed on most T lineage cells, NK cell subsets, and plasma cells. CD28 binds both CD80 and CD86 using a highly conserved motif MYPPY in the CDR3-like loop. CD28 is considered a major co-stimulatory molecule, inducing T lymphocyte activation and IL-2 synthesis, and preventing cell death. In vitro studies indicate that ligation of CD28 on T cells by CD80 and CD86 on antigen presenting cells provides a costimulatory signal required for T cell activation and proliferation. collapse

Description: CD24 is a 35-45 kD protein also known as Heat Stable Antigen (HSA), Ly-52, or Nectadrin. It is a GPI ... more

Description: CD24 is a 35-45 kD protein also known as Heat Stable Antigen (HSA), Ly-52, or Nectadrin. It is a GPI-linked sialoglycoprotein expressed on lymphocytes, granulocytes, epithelial cells, thymocytes, monocytes, erythrocytes, and dendritic cells. CD24 expression varies during T and B cell differentiation and is a useful marker for delineating various lymphocyte developmental stages. CD24 serves as an adhesion or costimulatory molecule involved in T and B lymphocyte activation and differentiation by homophilic binding or binding to CD62P. collapse