Actual treatment of bleeding duodenal ulcer is most frequently medical but also surgical. The aim of this study is to assess the factors that influence the outcomes for a group of 67 patients suffering of bleeding duodenal ulcer. Out of 67 patients considered in this study, 53 were men (79.1%) and 14 were women (20.9%). The average age was 52 years for men and 53 years for women (range 19-86 years). 59 (88%) were patients with known medical history of peptic ulcer disease. Endoscopy has been performed for 64 patients (95.6%). Specific medical treatment was started immediately for all patients. For 47 patients (70.1%) the hemorrhage stopped with conservative treatment, 8 patients (12%) benefit by endoscopic treatment and 12 patients (17.9%) underwent surgery. The postoperative morbidity rate was 16.7%. Comorbidities were present in 43 patients (64.2%). Failure of medical conservative treatment has been observed in 7 cases (13%), and failure of endoscopic procedures in 2 cases (20%). The risk factors involved in therapy outcomes of bleeding duodenal ulcer are: age, the severity of hemorrhage confirmed by endoscopy, the hemorrhagic episodes in medical history and the time of surgery. Conclusion: The prognosis of bleeding duodenal ulcer after bleeding is highly correlated with the time that the treatment starts, the severity of hemorrhage, comorbid conditions and age.