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Meg Ryan to Star in and Produce NBC Comedy

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The "Sleepless in Seattle" star will play a former hotshot New York editor in the half-hour from "Family Ties" Emmy nominee Marc Lawrence.

Meg Ryan is heading back to television.

The When Harry Met Sally star will topline an NBC comedy revolving around a former hotshot New York editor, The Hollywood Reporter has learned.

In the half-hour single-camera comedy from writer and former Family Ties Emmy nominee Marc Lawrence, Ryan will play a sunny, devoted and desperately nonconfrontational single mom who decides to return to her New York publishing house where she was once a brilliant editor to find that she now works for Brenda, a neurotic 30-year-old who was once her former intern. Now she must find a way to keep her boss, her teenage kids, her almost ex-husband and her meddlesome mother-in-law all happy, which results in her overcomplicating every situation and somehow always making it worse.

For Ryan, this marks her return to the small screen and NBC following her co-starring role in 1982's short-lived comedy One of the Boys with Mickey Rooney, Dana Carvey and Nathan Lane. Ryan, who recently appeared in multiple episodes of Showtime's Web Therapy, is repped by ICM Partners and Berliner's Authentic Talent and Literary Management. She also was a regular on ABC's short-lived 1985 Western, Wildside, which was canceled after one month.

The NBC comedy comes mere weeks after an October People magazine cover story that revealed the former Sleepless in Seattle star preferred to remain out of the Hollywood limelight and would rather focus on her family, including boyfriend John Mellencamp and her 8-year-old daughter, Daisy.

Ryan is a three-time Golden Globe nominee for romantic comedies Sleepless in Seattle, You've Got Mail and When Harry Met Sally. Lawrence is repped by UTA.