MARVELD1 mediated the invasion of trophoblast cells via regulation of the expression of integrin beta4 during placenta development.

MARVELD1 is a microtubule-associated protein that plays an important role in cell cycle progression and migration

Human MARVEL Domain Containing 1 (MARVELD1) Interaktionspartner

MARVELD1 substantially inhibits nonsense-mediated RNA decay by decreasing the pioneer round of translation but not steady-state translation, and is an important component of the molecular machinery containing UPF1 and Y14. MARVELD1 promotes the dissociation of SMG1 from UPF1, resulting in the repression of serine phosphorylation of UPF1, and subsequently blocks the recruitment of SMG5.