Both may show CD30+, CD15+, EBV+, CD20+ large cells with Reed-Sternberg morphology and polymorphic background infiltrate including plasma cells, histiocytes, and eosinophils; and present with generalized lymphadenopathy and constitutional symptoms

B cell proliferation may progress to diffuse large B cell lymphoma, less commonly other lymphomas

May progress to plasmablastic lymphoma

Not associated with HIV

Highly associated with HIV

Both may show reactive and atretic follicles, vascular proliferation, and proliferation of immunoblasts and plasma cells. Clinically both may have systemic lymphadenopathy, constitutional symptoms, and polyclonal hypergammaglobulinemia.