Human Solute Carrier Family 13 Member 2 (SLC13A2) Interaktionspartner

Mapping Functionally Important Residues in the Na(+)/Dicarboxylate Cotransporter, NaDC1.

NaDC1 is present throughout the entire proximal tubule, but was not detected in kidney tumors.

cyclophilin (zeige PPIA Antikörper) isoform B is likely responsible for down-regulation of carrier expression by CsA (zeige ERCC8 Antikörper) and that it does so via its chaperone activity on NaDC1 (by direct interaction) rather than its rotamase (zeige FKBP1B Antikörper) activity.

study concludes most of the naturally occurring nonsynonymous SNPs affect protein processing of NaDC1; several also affect functional properties; mutations are predicted to decrease transport activity

This paper describes the cloning and functional characterization of the human Na(+)-coupled citrate transporter (NaCT).

Data show that the sodium-dependent dicarboxylate co-transporter protein (zeige HNRNPU Antikörper) 1 is located in renal proximal tubule lumenal membranes, and that the C-terminal sequence is required for delivery and targeting and may contain the signal sequence.

The Ser (zeige SIGLEC1 Antikörper) or Thr (zeige TRH Antikörper) at position 509 is the most important determinant of functional differences in apparent affinity for substrate and cations. The cation and substrate binding sites are located in close proximity to one another.

Substrate-dependent inward currents, measured using two-electrode voltage clamp, were similar for glutarate & succinate in Xenopus oocytes expressing mouse NaDC1. Currents evoked by glutarate in rabbit NaDC1 were about 5% of succinate-dependent currents.

Sodium dicarboxylate cotransporter is involved in regulating levels of various Krebs cycle intermediates in the kidney, although impaired uptake of these intermediates does not significantly affect renal function under normal or ischemic stress.