Proscar

OVERDOSE

Patients have received single doses of PROSCAR up to 400 mg and
multiple doses of PROSCAR up to 80 mg/day for three months without adverse
effects. Until further experience is obtained, no specific treatment for an
overdose with PROSCAR can be recommended.

Significant lethality was observed in male and female mice at single
oral doses of 1500 mg/m² (500 mg/kg) and in female and male rats at single oral
doses of 2360 mg/m² (400 mg/kg) and 5900 mg/m² (1000 mg/kg), respectively.

CONTRAINDICATIONS

PROSCAR is contraindicated in the following:

Hypersensitivity to any component of this medication.

Pregnancy. Finasteride use is contraindicated in women when they are or
may potentially be pregnant. Because of the ability
of Type II 5α-reductase inhibitors to inhibit the conversion of
testosterone to 5α-dihydrotestosterone (DHT), finasteride may cause
abnormalities of the external genitalia of a male fetus of a pregnant woman who
receives finasteride. If this drug is used during pregnancy, or if pregnancy
occurs while taking this drug, the pregnant woman should be apprised of the
potential hazard to the male fetus. [See also WARNINGS AND PRECAUTIONS, Use
in Specific Populations, HOW SUPPLIED/Storage and Handling and PATIENT INFORMATION.] In female rats, low doses of
finasteride administered during pregnancy have produced abnormalities of the
external genitalia in male offspring.

Last reviewed on RxList: 5/2/2012
This monograph has been modified to include the generic and brand name in many instances.