FLUMOX® (amoxycillin sodium and flucloxacillin sodium) vial is given by injection; peak plasma concentrations are achieved in about 30 minutes following intramuscular injection. Doupling the dose can double the plasma concentrations. FLUMOX® is widely distributed at varying concentrations in body tissues and fluids. FLUMOX® is metabolized to a limited extent and the unchanged drug and metabolites are excreted in the urine and bile within 6 – 8 hours.

Adults: 0.5g • 1 g. every 6 – 8 hours.
Children: (2 -12 years):1I2 adult dose; children (less than 2 years):1/4 adult dose.
• Administration may be intramuscular, intravenous injection or infusion.
In severe infections, the vial may be given in infusion, every 4 – 6 hours.
For intramuscular injection, FLUMOX® vial 500 mg should be dissolved in 2 ml;
FLUMOX® vial 1000 mg should be dissolved in 4 ml of water for injection.
For intravenous injection, FLUMOX® vial 500 mg should be dissolved in 5 ml; but
FLUMOX® vial 1000 mg should be dissolved in 10 rnl of water for injection, given slowly over 3 – 4 minutes.
FLUMOX® vials should be injected immediately after reconstitution with distilled water.
FLUMOX® vial is stable with the commonty- used intravenous fluids at 2S·C, if infused over a maximum period of 6 hours.
• Solutions containing dextrose or other carbohydrates should be infused within
30 • 40 minutes and must be changed within 2 hours. Solutions containing sodium bicarbonate must be changed within 4 hours. FLUMOX® must not be mixed with blood products or proteinaceous fluids.

Precautions:

Doses should be reduced in severe renal impairment.

Contra-indications:

A known hypersensftivity to penicillins.

Side Effects :

As with other penicillins, side-effects are usually mild and transient including diarrhoea, indigestion and skin rashes.