Shin Megami Tensei: Persona 3 Portable allows the player to choose the gender of the protagonist unlike the PS2 version who only allows the player to be male.

The female protagonist's story line was slightly altered to appeal to experienced players who had already enjoyed the original story line, and (only in the female route) you have the ability to choose who will be Igor's assistant: the original female assistant, Elizabeth, or her brother, Theodore.