An improved development over the original MRX-009 Psycho Gundam, the Titans' MRX-010 Psycho Gundam Mk-II is very similar to its predecessor, equipped with a psycommu and psycho-control chair to allow its Newtype or genetically-engineered "cyber Newtype" pilot to control this massive mobile weapon system with mere thoughts. Like the original, the Mk-II can also transform into a "mobile fortress" mode equipped with a Minovsky craft system for atmospheric flight, although its firepower is much more deadly than the MRX-009's. Though armed with the same 3-barreled diffuse mega particle cannon in its chest and beam gun fingers, the Mk-II also mounts 20 smaller beam guns all over its body, giving it firepower capable of attacking targets in all directions. Its forearms also mount large-bladed beam swords, and can be detached and directed at targets via a cable connection and through the control of the Mk-II's psycommu system, giving the unit an all-range attack capability quite similar to that of Zeon's MSN-02 Zeong. The Mk-II also carries a set of "reflector bits," which are unarmed but used to redirect its own beam weapons fire to targets that are out-of-sight, or to deflect incoming enemy beam weapons fire. Another feature carried over from previous Newtype-use Zeon mobile weapons is its detachable head, which - in a fashion similar to the Zeong - can be flown and operated independently in the case of jettison or destruction of the Mk-II's main body.

Piloted by the powerful Cyber Newtype Rosamia Badam, all of these factors make the Mk-II a much, much deadlier foe for AEUG MSZ-006 Zeta Gundam pilot Kamille Bidan than the original Psycho Gundam ever was, though he does manage to critically damage it during a battle at the Gate of Zedan late during the Gryps Conflict. Almost a year later, Neo Zeon forces retrieve the wreckage of the Mk-II and rebuild it, employing it at the hands of their own Cyber Newtype pilot, Ple Two, in their war against the AEUG. Following a colony drop on the city of Dublin, the Mk-II is heavily damaged in a battle against Judau Ashta's MSZ-010 ZZ Gundam. After abandoning the Mk-II, Ple Two switches the equally massive (and more powerful) Neo Zeon-developed NZ-000 Queen Mansa.