All statistics were analyzed using SPSS 20 (IBM, Armonk, New York). All data were normally distributed. Independent, paired Student t tests and 1-way analysis of variance with Bonferroni’s correction were performed to compare groups. A p < 0.05 was considered significant.

The medium term effects of 2 common forms of bariatric surgery on cardiovascular remodeling are assessed in this pilot study. We have shown that RYGB results in greater reduction in abdominal visceral fat, and greater reversal of LV remodeling and aortic stiffness than LAGB. Furthermore, we have shown that although remaining obese following RYGB, LV mass, concentric remodeling, and aortic elastic function return to normal. Overall, this suggests that as long as visceral fat is reduced, a return to normal BMI is not necessary for complete resolution of the cardiovascular structural and functional changes in obesity. Larger studies are needed to confirm these findings and establish how the reduction in abdominal visceral fat mediates these improvements independently from other fat depots.

Footnotes

Please note: The study was supported by grants from the Wellcome Trust and British Heart Foundation (BHF). Drs. Shah and Rider were supported by the Oxford BHF Centre of Research Excellence and the Oxford National Institute for Health Research Biomedical Research Centre. Dr. Banerjee owns stock in Perspectum Diagnostics. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.

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