Thursday, August 11, 2016

Eurosurveillance: 2 Reports Of Zika RNA Detection In Semen Six Months After Infection

#11,625

With the caveat that detection of viral RNA is not the same as the isolation of live, viable, virus - we've two reports in the journal Eurosurveillance suggesting that the Zika viral RNA may remain detectable for as long as six months in some post-convalescent patients.

Whether either of these patients are capable of passing on the Zika virus at this late stage is unknown, although the authors admit it is possible.

The links and abstracts follow.

Eurosurveillance, Volume 21, Issue 32, 11 August 2016Rapid communicationInfection
dynamics in a traveller with persistent shedding of Zika virus RNA in
semen for six months after returning from Haiti to Italy, January 2016L Barzon 1 2 , M Pacenti 2 , E Franchin 1 2 , E Lavezzo 1 , M Trevisan 1 , D Sgarabotto 3 , G Palù 1 2We
describe the dynamics of Zika virus (ZIKV) infection in a man in his
early 40s who developed fever and rash after returning from Haiti to
Italy, in January 2016. Follow-up laboratory testing demonstrated
detectable ZIKV RNA in plasma up to day 9 after symptom onset and in
urine and saliva up to days 15 and 47, respectively. Notably, persistent
shedding of ZIKV RNA was demonstrated in semen, still detectable at 181
days after onset.

A man in his early 30s reported in January 2016 a history of fever, asthenia and erythematous rash during a stay in Haiti. On his return to Italy, ZIKV RNA was detected in his urine and saliva 91 days after symptom onset, and in his semen on day 188, six months after symptom onset. Our findings support the possibility of sexual transmission of ZIKV and highlight the importance of continuing to investigate non-vector-borne ZIKV infection.

(SNIP)

Public health impact

The European Centre for Disease Prevention
and Control and the World Health Organization recommend that all
travellers returning from areas with ongoing ZIKV transmission should
adopt safer sex practices or consider abstinence for at least eight
weeks after their return [4,19]; if men have ZIKV-related symptoms, they should adopt safer sex practices or consider abstinence for at least six months.

Considering the 80% incidence rate of asymptomatic ZIKV infection [20],
further studies are needed to assess viral persistence in asymptomatic
men and the potential risk for sexual transmission and fetal
abnormalities following infection during pregnancy. The prolonged
genital shedding reported here may have implications for screening
measures to detect ZIKV RNA for semen cryopreservation in sperm banks [21].