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"House" star Amber Tamblyn has been cast to play Jenny, Sheen's character Charlie Harper's long-lost daughter on "Two and a Half Men's" upcoming 11th season, CBS confirms to E! News. Tamblyn will be billed as a recurring guest star for at least five episodes of the CBS sitcom after Jenny moves to Los Angeles to pursue a career in acting and to reconnect with what's left of her family after Charlie's death.

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Aside from her time on "House," Tamblyn is known for CBS' "Joan of Arcadia" and her work in films such as "The Sisterhood of the Traveling Pants," "127 Hours" and "Django Unchained."

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E! recently chatted with creator Chuck Lorre, who teased Jenny's introduction into Walden (Ashton Kutcher) and Alan's (Jon Cryer) lives. "The character as we know her now as she only exists on the page, is a pretty remarkably strong and ballsy character," he teased of Jenny, calling her "a chip off the old block."

E! News exclusively reported that Jenny would share her father's interest in women, with Lorre telling us, "The idea that she loves women seems to be something that just felt right."

However, Lorre added that Jenny wouldn't be a lesbian, but would be "bisexual."

One thing Lorre would rule out about Jenny's introduction was a potential romance with Walden. "I think it's going to be uncomfortable at first, then maybe over time there might be some affection there," he spilled. "I think the affection goes beyond sexuality, he just truly likes this young woman."

Another big change for season 11 of the hit series is Angus T. Jones' departure from the opening credits as he will no longer be a series regular. "I'm hopeful that he'll carve out some time to do some episodes and he's certainly not written out of the series by any means," Lorre told E! News of the young star, who made headlines after he infamously trashed the series.

Tamblyn is just the latest new lady in Sheen's TV life as Laura Bell Bundy has just been tapped to replace Selma Blair on his FX sitcom "Anger Management."