Wednesday, March 18, 2009

Salam! As far as I know, only acute promyelocytic leukemia (AML3) can primarily cause DIC. Correct me if I’m wrong. Basically DIC in AML resulting from infiltration of myeloid cells in bone marrow which leads to thrombocytopenia.

Promyelocytic leukemia is an accumulation of immature granulocyte (could be lineage of myeloblast or megakaryoblast)

So whenthe immature granulocyte increase, it means that less functional platelet can be formed.

The mechanism of DIC induction in patients with AML-M3 appears to involve the primary granules of the transformed promyelocytes. These primary granules contain a thromboplastin-like substance capable of activating the extrinsic system of coagulation as well as cancer procoagulant, a factor X activator.5,6,15-- 17 The release of these substances sets the abnormal clotting phenomenon in motion such that the greater the release of primary granules, the greater the clotting, and the more severe the symptoms, M3 produces increased numbers of promyelocytes, which results in a large degree of cell death and the release of massive amounts of granule contents.

Waktu Solat

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