Principal name

Alternative names for MHC Class I H-2Ld antibody

SwissProt ID

Ncbi ID

Available reactivities

Ms (Mouse)

Available hosts

Mouse

Available applications

Cytotoxicity Assay (CT), Flow Cytometry (F)

Background of MHC Class I H-2Ld antibody

The classical MHC Class I molecules are histocompatibility antigens encoded by the H-2 gene complex and consist of heterodimers of highly polymorphic alpha chains noncovalently associated with the invariant Beta2-microglobulin. These antigens are expressed on most nucleated cells but expression varies on different cell types. MHC Class I molecules present endogenously synthesized peptides to CD8+ T lymphocytes, which are usually cytotoxic T cells. MHC Class I antigens expressed on thymic epithelial cells regulate the positive and negative selection of CD8+ T cells during T cell ontogeny.