except for those people who have a 10gb profile and decide to login to other computers on a frequent basis.

And just using roaming profiles doesn't solve the profile bloat issue, it can happen very quickly on some machines (for example a shared workstation or in a computer lab) - in which case the time spent deleting the profile folders and registry keys dramatically improves login time for everyone using that computer.

EDIT: Also the registry path (in Win 7) for the profile list is - HKEY_LOCAL_MACHINE/SOFTWARE/Microsoft/Windows NT/CurrentVersion/ProfileList - then make sure the profile folder is deleted or renamed then Restart, and then the next time the account logs in it should create a new profile.