I became interested in cancer research during medical school and residency. During my early fellowship training in Hematology and Oncology I explored the biology of B and T lymphocytes and the role of cytotoxic T lymphocytes in murine models of EBV-associated lymphoproliferative disease. I subsequently became interested in using the molecular biology of signal transduction to investigate pathways underlying cancer cell invasion and metastasis. My laboratory joined the Molecular Oncology Research Institute in 2003 and transitioned to the Division of Hematology/Oncology in 2017. We are exploring the role of the tumor microenvironment in breast cancer biology, with a specific focus on how intra-cellular and inter-cellular signaling pathways are affected in the co-evolution of breast cancer and the breast cancer microenvironment. A major aim is translating our findings in the laboratory to the development of prognostic, predictive, and therapeutic tools for the treatment of patients with breast cancer.

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