Custom antibody development

We offer world-leading antibody development platforms based on a proprietary RabMAb® rabbit monoclonal platform, a phase display platform (AxioMx), and a next-generation sequencing platform (NGS-RabMAb®)

Target

Function

Repair polymerase. Conducts "gap-filling" DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases. Has a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.

Sequence similarities

Belongs to the DNA polymerase type-X family.

Domain

Residues 239-252 form a flexible loop which appears to affect the polymerase fidelity.

Post-translationalmodifications

Methylation by PRMT6 stimulates the polymerase activity by enhancing DNA binding and processivity.

Thank you for contacting us for technical support with ab1831.
This antibody has not been tested on mouse samples and we would not predict it to work on mouse tissue samples in immunohistochemical techniques due to the problem of mouse-on-mouse stai...

I'm sorry to hear you are having problems with ab1831 in IHC.
The fact that the antibody still works in WB suggests that the antibody is fine but that there is a component in the IHC protocol which is damaged, there could potentially be many "ingre...

Thank you for the information. We have not received any other complaints regarding this antibody and since the previous vial of ab1831 worked for you, it sounds like perhaps there is a problem with the latest vial that you received. I'm sending you a r...

Thank you for your email. I can send you a replacement vial of ab1831, it is no problem. But can you be more specific regarding the samples that you are using? Also, when approximately did you order the vial of ab1831 that did work for you? That inform...