This page contains links to various software resources associated with our research. ​ Feel free to email [[dbalick@research.bwh.harvard.edu]] if you have any questions, comments, or suggestions.

This page contains links to various software resources associated with our research. ​ Feel free to email [[dbalick@research.bwh.harvard.edu]] if you have any questions, comments, or suggestions.

-

===== Selection, dominance, and demographic history =====

-

Below is the simulation code for Balick, et. al. "​Response to a population bottleneck can be used to infer recessive selection"​ (2013 preprint available here: [[http://​biorxiv.org/​content/​early/​2014/​03/​21/​003491| biorxiv]]), currently under review. ​ This simulation was also used in Do, et. al. "No evidence that selection has been less effective at removing deleterious mutations in Europeans than in Africans"​ ([[No evidence that selection has been less effective at removing deleterious mutations in Europeans than in Africans|Nature Genetics 2015]]).

-

==== README ====

-

{{README.pdf|README}}

+

===== MUTATIONAL BURDEN SIMULATOR =====

-

==== Code ====

-

{{burden_sim.h}}

+

----

-

==== ​Compiled ​code ====

+

written by David Reich

+

+

+

+

==== Simulating selection and dominance in a non-equilibrium demography ====

+

+

+

How does a population bottleneck impact the mutation burden under differing dominance and selection coefficients?​

+

+

Below is the code for **burden_sim**,​ a simulation of the mutation burden for two populations after a split, as described in Balick, et al., //Response to a population bottleneck can be used to infer recessive selection// (2013 preprint available here: [[http://​biorxiv.org/​content/​early/​2014/​03/​21/​003491| biorxiv]],​currently under review). ​ This simulation was also used in Do, et al., //No evidence that selection has been less effective at removing deleterious mutations in Europeans than in Africans// ([[http://​www.nature.com/​ng/​journal/​v47/​n2/​abs/​ng.3186.html|Nature Genetics 2015]]).