I am on methotrexate tablets 8 on a Friday. I have an appointment on Thursday tomorrow. Last time I saw my RA consultant he told me to stop Sulphasalazine but stay on methotrexate. I have been suffering for over a year with very loose bowel movements. The consultant thought it was caused by Sulpha but after 5 weeks off that I am still suffering, anyone else suffer this way. Thanks

7 Replies

I also suffer with this and am on MTX. I was only on 7.5 for 2 months when I had a very bad episode of blood loss with the diarrhoea and ended up in hospital. My rheumatologist thinks it was "unlikely" to have been caused by MTX so started taking it again 3 weeks ago. The diarrhoea continues but am seeing a gastroenterologist next week as my doctor thinks I have Ulcerative Colitis. Clemmie

I had constant diarrhoea with MTX (as well as nausea, vomiting and large mouth ulcers). The only help with that was when the pain was at its worst I took codeine for pain relief which slowed it all down a bit!