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A Randomized Trial Comparing 5-Fluorouracil, External Beam Radiation, and Gemcitabine With or Without P Radiopharmaceutical Therapy As A First Line Therapy in Patients With Locally/Regionally Advanced Non-Resectable Adenocarcinoma of the Pancreas

Trial Information

A Randomized Trial Comparing 5-Fluorouracil, External Beam Radiation, and Gemcitabine With or Without P Radiopharmaceutical Therapy As A First Line Therapy in Patients With Locally/Regionally Advanced Non-Resectable Adenocarcinoma of the Pancreas

OBJECTIVES:

Primary

- Compare the survival of patients with locally or regionally advanced unresectable
adenocarcinoma of the pancreas treated with fluorouracil, external beam radiotherapy,
and gemcitabine with vs without brachytherapy with phosphorus P32 suspension.

Secondary

- Compare time to disease progression, tumor response rate, and physical performance in
patients treated with these regimens.

- Compare the safety and tolerability of these regimens in this patient population.

- Compare duration of response and time to treatment failure in patients treated with
these regimens.

OUTLINE: This is a randomized study. Patients are randomized to 1 of 2 treatment arms.

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