Wednesday will be just the second game Bosh has missed all season, and it will be interesting to see how Miami copes. The Rockets are red hot after tying an NBA record with 23 three-pointers versus the Golden State Warriors on Tuesday.

While Houston doesn't have the league's best interior presence, it almost goes without saying how much Bosh means to the Heat.

Bosh oftentimes doesn't get the ink (or computer space) of LeBron James and Dwyane Wade, but his versatility is integral to everything Miami does. The longtime power forward shifted over to center this season so Erik Spoelstra could implement a "small ball" strategy, and Bosh's willingness to do so has masked the Heat's lack of interior depth.

As evidence, Spoelstra will likely turn to Joel Anthony for the start on Wednesday. Anthony is a well-liked veteran leader, but he's an offensive liability, as is Chris Andersen, who will also see increased minutes against Houston.

Bosh, meanwhile, is averaging 17.5 points, 7.1 rebounds and 1.3 blocks per game, and his efficiency has been especially impressive. The 28-year-old has a player efficiency rating of 20.61 coming into Wednesday night, thanks mostly to a career-high 54.6 field-goal percentage. Miami also scores nearly four points per 100 possessions more when he's on the floor, per NBA.com.

James and Wade may be able to carry the offensive load for one or two nights, but don't expect Bosh's absence to go unnoticed.

Be sure to check back in as we give you the latest updates on Bosh's flu and his possible return date.