Affiliation: Department of Metabolic Medicine Graduate School of Medicine Osaka University Suita City Osaka Japan.

ABSTRACT

Aims/introduction: To establish the validity of the plasma glucose disappearance rate (KITT), derived from an insulin-tolerance test (ITT), for evaluating the insulin sensitivity of patients with type 2 diabetes after insulin therapy.

Materials and methods: In the first arm of the study, 19 patients with poorly controlled diabetes were treated with insulin and underwent an ITT and a euglycemic clamp test (clamp-IR). The relationship between the insulin resistance index, as assessed by both the clamp-IR and KITT tests, was examined. In the second arm of the study, the relationships between KITT values and various clinical parameters were investigated in 135 patients with poorly controlled diabetes, after achieving glycemic control with insulin.

Results: In study 1, a close correlation between KITT and the average glucose infusion rate during the last 30 min of the standard clamp-IR test (M-value) was noted (P

Conclusions: The ITT is a valid and useful test for evaluating the insulin sensitivity of patients with diabetes, even after treatment with insulin.

Affiliation:
Department of Metabolic Medicine Graduate School of Medicine Osaka University Suita City Osaka Japan.

ABSTRACT

Aims/introduction: To establish the validity of the plasma glucose disappearance rate (KITT), derived from an insulin-tolerance test (ITT), for evaluating the insulin sensitivity of patients with type 2 diabetes after insulin therapy.

Materials and methods: In the first arm of the study, 19 patients with poorly controlled diabetes were treated with insulin and underwent an ITT and a euglycemic clamp test (clamp-IR). The relationship between the insulin resistance index, as assessed by both the clamp-IR and KITT tests, was examined. In the second arm of the study, the relationships between KITT values and various clinical parameters were investigated in 135 patients with poorly controlled diabetes, after achieving glycemic control with insulin.

Results: In study 1, a close correlation between KITT and the average glucose infusion rate during the last 30 min of the standard clamp-IR test (M-value) was noted (P

Conclusions: The ITT is a valid and useful test for evaluating the insulin sensitivity of patients with diabetes, even after treatment with insulin.