The Brownlee SPP (Superficially Porous Particle) HILIC column contains a high purity silica substrate. This column is filled with 2.7 μm superficially porous particles that contain a 1.7 μm solid inner core and a 0.5 μm porous silica outer shell, allowing for a shorter diffusion path and nearly double the efficiency compared to traditional fully porous silica particles. It can be used to enhance the performance of both traditional HPLC systems and UHPLC systems and is compatible with 2 µm inlet frits, so traditional solvents and sample preparation techniques can be used. Specialized filters are not needed for UHPLC systems.