I voted Brainiac. If nothing else, I'd love to see an adaptation of Alan Moore's "The Last Superman Story", if for nothing else than to see Kevin Spacey wearing the big evil Brainiac hat. Heh heh.

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"Don't make me stain my last clean shirt with the back of your head." - Shatter Dead"A grizzly bear with a chainsaw. Now THERE's a killing machine!" - The Simpsons"I've always wanted to make love to an angry welder." - Jaws: the Revenge

Why not one-up three of the Batman films as well as the last Spider-Man film and throw all of them in there?

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I'd like to see Luthor and Bizarro, Mr. Mxyzptlk may be a bit too obscure for cinema goers and also a huge amount of effects would be needed for the stuff he can do or does whenever he shows up in the comics.

I haven't had projectile dairy from my nose since elementary school. Congratulations.

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"Don't make me stain my last clean shirt with the back of your head." - Shatter Dead"A grizzly bear with a chainsaw. Now THERE's a killing machine!" - The Simpsons"I've always wanted to make love to an angry welder." - Jaws: the Revenge

Though the point of the thread is who should be in the movie, here's the likelihood for each of these guys, as based on random numbers taken directly from no particular source:

Lex Luthor - 99% (probably bringing along one of the others as a minion)

Bizarro - 60% (recognizable, could be brought in under the "failed Superman clone" pretense)

Metalo - 50% (could easily be done as a Luthor minion, but doesn't have the mainstream presence that some of the other do)

Mr. Mxyzptlik 2% (as it's been said, the CGI budget to do all his wacky things would be pricey, not to mention he's a comical imp, so basing an attempted blockbuster movie around Superman fighting a comical imp is going to be reeeeeeeally hard to get approval for)

Brainiac 75% (Probably the easiest of the group to recreate in movie form: green makeup and headgear)

Doomsday 85% (Everybody knows the behemoth that killed Superman, and he could easily be either a Luthor creation or salvaged from space by Luthor)

Darkseid 40% (Not as mainstream friendly, you'd have to include his history and Apokalips into the mix, and George Lucas might try to sue )

Mongul - 10% (also not too mainstream friendly and could easily be replaced with Doomsday or Darkseid)

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"Don't make me stain my last clean shirt with the back of your head." - Shatter Dead"A grizzly bear with a chainsaw. Now THERE's a killing machine!" - The Simpsons"I've always wanted to make love to an angry welder." - Jaws: the Revenge

I think It should go down like this: Braniac is the big bad guy and either creates Bizzaro or summons him from Htrae (Bizarro world) to deal with Superman but in the very end, Bizarro helps Superman defeat Braniac.