I basically uninstalled all com drivers, Avrstudio etc to make sure I had a clean install.

I reinstalled AVRStudio 4Installed com0Com and set ports to 4 and 9Installed USBTiny500 In my device manager I have .. Com4 and Com9 listed under Ports and are working properly... com0com is working properly... libusb-win32 working properly.

When I use USBTinyISP, swapping between 4 and 9 gives Opening port COMX and then hangs there. If I close USBTinyISP and reopen, it says READY.