Importantly, the A4 has translational value due to its unmatched sensitivity and applicability in various sample types. The same method can be used to:

determine the mechanism of action and to identify your lead compound in an in vitro screening.

detect Aβ oligomers in samples from transgenic animal models.

measure Aβ oligomers in clinical samples.

Assay format:

96 well

Read-out:

Electrochemiluminescence

Application:

Brain homogenates

In vitro aggregated Aβ

CSF

Species:

Any

Reduction of Aβ aggregation in hAPP transgenic mice treated with a β-secretase (BACE) inhibitor and a vaccine, respectively. (A) Dose-dependent effect of a novel BACE inhibitor on aggregated Aβ species in hippocampi of 8 months old male hAPPwt mice. Shown are mean + SEM, n=5. (B) Effect of a vaccine on aggregated Aβ species in hemibrains of 16 months old APP/Tg2576 mice. Shown are mean + SEM, n=8.