UTILIZATION of modified MMT in drug delivery is now taking a …….great attention due to the considerable efficiency and miscellaneous drug type. In this study, different types of cationic carbohydrate are used for MMT to optimize the best for loading and release. Tert- aminated starch (AmS) and chitosan (CS), bearing primary amino groups, are used for modification of MMT to evaluate the feasibility of loading and release of Praziquantel drug with applicable efficiency. The modified clay was characterized by XRD, TGA and SEM. The characterization via XRD and SEM demonstrates that the chitosan has greater exfoliated intercalation properties than the Tert- aminated starch. The loading efficiency of Praziquantel by modified MMT with AmS, and chitosan was 19.5 % and 22.1 % , respectively. Drug release was studied for CS/MMT –Praziquantel hybrid and it was found that the release was directly proportional with the pH of the medium and reached to 82% at pH 7.4 after 6 hr.