The AE/IS `Charles Simonyi' Symposium: Grand Challenges of Informatics is a major event. Some 14 of the nest computer scientists will, over two days, present challenges within areas of 100% trustworthy software, quantum computing, biocomputing, economics and game theory, and the relations between informatics and mathematics. Thanks to Dr. Simonyi's donation the event will host some 40 young scientists from Central and Eastern European countries.