..The present results suggest that the medial striatum may be critical for flexible adaptations involving spatial information, and that ACh actions in this area enable the shifting of choice patterns when environmental conditions change...

..The results suggest that the dorsomedial striatum is important for behavioral flexibility and that activation of muscarinic cholinergic receptors in this region may facilitate the learning of situationally adaptive response patterns...

The effects of dopamine D(1) receptor blockade in the prelimbic-infralimbic areas on behavioral flexibility

..These results suggest that activation of dopamine D(1) receptors in the prelimbic-infralimbic areas may be critical for the suppression of a previously relevant strategy and/or generating new strategies...

Role of the dorsomedial striatum in behavioral flexibility for response and visual cue discrimination learning

..Thus, specific circuits in the prefrontal cortex and striatum may interact to enable behavioral flexibility, but each region may contribute to distinct processes that facilitate strategy switching...

The effects of prelimbic and infralimbic lesions on working memory for visual objects in rats

..Prelimbic-infralimbic lesions did not impair acquisition of the visual object discrimination. The results suggest that the prelimbic-infralimbic areas are part of neural system important in the short-term memory for visual objects...

The effect of rat anterior cingulate inactivation on cognitive flexibility

..Together, the present findings indicate that the Pf is an intralaminar thalamic nucleus critical for behavioral flexibility, in part, by directly affecting striatal ACh output under conditions that require a shift in choice patterns...

The contribution of NMDA receptors in the dorsolateral striatum to egocentric response learning

Carlos A PalenciaDepartment of Biological Sciences and Laboratory of Integrative Neuroscience, University of Illinois at Chicago, Chicago, IL 60607, USBehav Neurosci 119:953-60. 2005

..Neither AP-5 dose impaired response reversal learning. The results suggest that NMDA receptors in the dorsolateral striatum are critical for the initial learning of an egocentric response discrimination...

Differential involvement of M1-type and M4-type muscarinic cholinergic receptors in the dorsomedial striatum in task switching

..The results suggest that activation of M(1) muscarinic cholinergic receptors, but not nicotinic cholinergic receptors, in the dorsomedial striatum is important for facilitating the flexible shifting of response patterns...

The influence of NMDA receptors in the dorsomedial striatum on response reversal learning