Genetic predisposition:1 parent with major depressive disorder,10-13% chance of mood disorder in child

Stressful life eventBiological alteration in brain functionCognitive triad:-ve self-view (things are bad because I’m bad)-ve view of past (everything has always been bad)-ve view of the future (I’ll fail)

Causes

continuous low mood or sadnessfeeling hopeless and helplesshaving low self-esteem feeling tearfulfeeling guiltfeeling irritable and intolerant of others having no motivation or interest in thingsfinding it difficult to make decisionshaving suicidal thoughts or thoughts of harming oneselffeeling anxious or worried Moving or speaking more slowly than usual change in appetite or weight (usually decreased, but sometimes increased) Constipationunexplained aches and painslack of energy or lack of interest in sexchanges in menstrual cyclenot doing well at worktaking part in fewer social activities and avoiding contact with friendsneglecting hobbies and interestsPsychological:Cognitive (Triad of feeling hopeless, helpless to self, future & past)BehaviouralSupportiveFamily therapy