The safety and tolerability of ChAdOx1 LS2 administered alone and with MVA LS2 in a prime-boost vaccination regimen in healthy malaria-naive volunteers assessed by the frequency and severity of adverse events.

The efficacy of ChAdOx2 LS2 and MVA LS2 administered in a prime-boost vaccination regimen against malaria sporozoite challenge, in healthy malaria-naive volunteers.

Laboratory toxicities related to vaccination that are classified as Grade 3(Severe). Grade 3 being defined as events that interrupt the subject's usual daily activities and may require systemic drug therapy or other treatment.

Compliance with intervention as measured through spot checking and weighing of repellent bottles

Protective efficacy of uniforms measured by reduction in Anopheles arabiensis bites among those wearing uniforms for a sub-sample of uniforms tested under laboratory conditions with free flying mosquitoes