Association between HRAS rs12628 and rs112587690 polymorphisms with the risk of melanoma in the North American population

@inproceedings{Tomei2012AssociationBH,
title={Association between HRAS rs12628 and rs112587690 polymorphisms with the risk of melanoma in the North American population},
author={Sara Tomei and Sharon D. Adams and Lorenzo Uccellini and Davide Bedognetti and Valeria De Giorgi and Narnygerel Erdenebileg and Maria Libera Ascierto and Jennifer Reinboth and Qiuzhen Liu and Generoso Bevilacqua and Ena Wang and Chiara M Mazzanti and Francesco M. Marincola},
booktitle={Medical oncology},
year={2012}
}

HRAS belongs to the RAS genes superfamily. RAS genes are important players in several human tumors and the single-nucleotide polymorphism rs12628 has been shown to contribute to the risk of bladder, colon, gastrointestinal, oral, and thyroid carcinoma. We hypothesized that this SNP may affect the risk of cutaneous melanoma as well. HRAS gene contains a… CONTINUE READING