The goal of the I4C Collaboratory is to develop novel combined immunologic approaches to cure HIV-1 through a highly collaborative and multifaceted research program involving leading investigators in academia, government and industry. Our overall hypothesis is that a combined immunologic approach that optimizes antiviral humoral and cellular immune responses, together with latency reversal, will effectively reduce or control the viral reservoir in ART-suppressed, HIV-1-infected individuals to achieve a functional cure.