Tymovirus

VIRION

GENOME

Linear, C-rich, ssRNA(+) genome of 6.3 kb. The 3'-terminus has a tRNA-like structure.

GENE EXPRESSION

The virion RNA is infectious and serves as both the genome and viral messenger RNA. The ORF1 encodes a polyprotein whichis expressed by leaky scanning. The capsid protein is translated from a subgenomic RNA.

REPLICATION

CYTOPLASMIC

Virus penetrates into the host cell.

Uncoating, and release of the viral genomic RNA into the cytoplasm.

The viral RNA is translated to produce the protein necessary for RNA synthesis (replication and transcription).

Replication occurs in viral factories. A dsRNA genome is synthesized from the genomic ssRNA(+).