Ets1-related protein plays a critical role in the initiation of definitive hematopoiesis by controlling the expression of 2 stem cell leukemia (scl) isoforms (scl-alpha and scl-beta) in angioblasts.

etsrp embryonic expression is only restricted to vascular endothelial cells and their earliest precursors. Morpholino knockdown of Etsrp protein function resulted in the complete absence of circulation in zebrafish embryos.

Human Ets Variant 2 (ETV2) Interaktionspartner

ETS transcription factor Etv2, a critical factor for haematopoietic and vascular development, is also required for haematopoietic regeneration. Etv2, which is silent in homeostatic HSCs, was transiently activated in regenerating HSPCs and was required for the HSC expansion and regeneration following bone marrow transplantation or haematopoietic injury.

REVIEW. the interplay among the ETS transcription factor ETV2, vascular endothelial growth factor, and its receptor VEGFR2/FLK1 is essential for hematopoietic and vascular development. Emerging studies also support the role of these three factors and possible interplay in hematopoietic and vascular regeneration.

Mouse (Murine) Ets Variant 2 (ETV2) Interaktionspartner

HIF1alpha activation of Etv2 in embryonic stem cells followed by NOTCH1 signaling is required for the generation arterial endothelial cells that are capable of arteriogenesis and revascularization of ischemic tissue.

This study aimed to evaluate the effects of the E-twenty six (ETS) factor Ets variant 2 (ETV2) gene expression in angiogenesis and the effect of ETV2 gene therapy in a mouse model of hindlimb ischemia.

Gata2 functions as a cofactor of Etv2 in the transcriptional regulation of mesodermal progenitors during embryogenesis.

study demonstrated using the embryonic stem cell/embryoid body system that Etv2 could rescue the Flk1 mutant phenotype, but Flk1 could not rescue the Etv2 mutant phenotype, further supporting the notion that the Flk1-Etv2 cascade is operational during hemato-endothelial development

study to show the critical timeframe of Etv2 requirement and help to know if Etv2 has any function around E9.5 when most endothelial cells(EC) have completed differentiation; also tried to examine if Etv2 expression can define a distinct intermediate step of EC differentiation from Flk-1+/VECAD- mesoderm to VECAD+ differentiated ECs

VEGF activates Etv2 by signaling through Flk1, which activates Creb through the p38 MAPK signaling cascade.

Studies demonstrate that Etv2 is expressed during and required for yolk sac hematoendothelial development, and that Lmo2 is one of the downstream targets of Etv2.

ETV2 marks hemogenic endothelium in gastrulating embryos and is absolutely required for the formation of this precursor at the onset of hematopoiesis.