Shigella dysenteriae - Xen27

S. dysenteriae - Xen27 bioluminescent pathogenic bacteria for in vivo and in vitro drug discovery. This product was derived from the 88A6205 clinical isolate. S. dysenteriae-Xen27 possesses a stable copy of the Photorhabdus luminescens lux operon on the bacterial chromosome.

Infectious disease is a perennially important area for both life science research and drug discovery. Some of the first applications of IVIS® imaging technology were in tracking infections and monitoring host responses, and these applications are still at the forefront of research. PerkinElmer's bioluminescent infectious disease light-producing microorganisms have been developed to mimic both acute and chronic standard infection protocols presently used by researchers.

Engineered Bacterium: Shigella dysenteriae - Xen27

Parental Strain: 88A6205 clinical isolate

In Vitro/Ex Vivo: Growth profiles

In Vivo: Not tested

Advantages of using bioluminescent light-producing microorganisms for drug discovery in vitro:

Rapid and readily amenable to high throughput screening, e.g., 96 or 384-well format