The team’s decision to deactivate offensive lineman John Urschel, who had been dealing with a shoulder ailment all week, means Alex Lewiswill start at left guard next to left tackle Ronnie Stanley. Lewis, a fourth-round pick, and Stanley, the sixth overall selection, will be the first rookies for any team to start at left guard and left tackle in a season opener since 1995, according to the Elias Sports Bureau.

Both Stanley and Lewis said they expect Bills coach Rex Ryanto target their pass-blocking abilities frequently.

“It’s something I’m aware of and have just been preparing for,” Stanley said this week. “I’m sure I’m going to get that a lot during the season. So I’ve just got to be ready for it.”

Added Lewis: “They’re going to test us. That would be my assumption. I never know. This is my first NFL game. So I’ve got no clue. I’m just going in there knowing what I’ve got to do and do that.”