In the interview held at Cissy's New Jersey home, she talks about raising a daughter whose voice became a national treasure, teaching Whitney about the music business -- and her biggest regrets. Oprah also talks to Cissy about when and what she knew about Whitney’s drug use, how she really felt about her daughter’s marriage to R&B singer Bobby Brown and the true nature of Whitney’s relationship with her high school best friend, Robyn Crawford.

Oprah also talks to Whitney's older brother, Michael Houston, for the first time since his sibling's death, and he emotionally reveals the origin of Whitney’s drug use.