Treatment

Physostigmine salicylate, 1 to 2 mg, SC or IV, reportedly
will reverse symptoms of anticholinergic intoxication.** A second injection may
be given after 2 hours if required. Otherwise treatment is symptomatic and
supportive. Maintain respiration. A short-acting barbiturate may be used for
CNS excitement, but with caution to avoid subsequent depression; supportive
care for depression (avoid convulsant stimulants such as picrotoxin,
pentylenetetrazol, or bemegride); artificial respiration for severe respiratory
depression; a local miotic for mydriasis and cycloplegia; ice bags or other
cold applications and alcohol sponges for hyperpyrexia, a vasopressor and
fluids for circulatory collapse. Darken room for photophobia.

CONTRAINDICATIONS

Hypersensitivity to any component of COGENTIN injection.

Because of its atropine-like side effects, this drug is
contraindicated in pediatric patients under three years of age, and should be
used with caution in older pediatric patients.