Measuring sodium accumulation in MS: Development and application of 23-Na MRI across different MS sub-groups

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Speaker information: Bhavana Solanky, Queen Square MS Centre, NMR Research Unit, UCL Institute of Neurology. Host: UCL Institute of Neurology, Queen Square MS Centre Seminar Series 2013.
Abstract: Neuroaxonal loss is associated with disability in multiple sclerosis (MS), however its cause is not understood. A lethal accumulation of intracellular sodium concentration has been postulated. Sodium (23Na) magnetic resonance imaging measures total sodium concentration in the brain. The development of unique sodium magnetic resonance imaging protocols and the application of these to a range of MS subgroups will be presented, in addition to the development of a novel method with which to measure sodium in the spinal cord.