I make different mixes depending on what I'm doing, but there's usually at least one Genesis (or member of), song involved in each one. Then maybe some George Winston or Yanni or Liz Story...something along those lines. There's also always some Tool in there if I'm working on a darker piece. Oh, and I also can't forget Frou Frou or Imogen Heap.

Like many others here, I also tend to make specific mixes for various type of work, though I prefer no background music when I'm writing. When I'm drawing however, I like to listen to mostly soundtracks and moody rock/ambient stuff:

On the other hand, if I'm doing something tedious at work (like rotoscoping), I would pick something loud and obnoxious just to stay awake...speed metal and prog rock usually do the trick. Probably not so good for creative thinking though.

When I'm concepting, I need silence. For intense drawing, I sometimes can listen to music. When I go totally right brain, I like to keep my left brain occupied with comedy podcasts: Nerdist, Kevin & Bean, I Love Movies, Adam Carolla.

Anyone else use last.fm? I just found a good scrobbler for the Mac (ScrobblePod) and have recently started using the service again. Here's what I'm listening to now: http://www.last.fm/user/nateomedia