Overview

Replacement Information

Description

Overview

Synthetic [Arg8]-Vasopressin. An antidiuretic peptide hormone. Released from the hypothalamus during stress. Although noted primarily for its hemodynamic and hemostatic properties, it appears to affect the immune system. Acts via the activation of the adenylate cyclase system resulting in increased cAMP levels (EC50 = 34 nM). Reported to induce an increase in [Ca2+]i in hippocampal neurons via action of VI vasopressin receptors coupled with N-type Ca2+ channels.

References

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision

04-August-2008 JSW

Synonyms

AVP

Description

Synthetic [Arg8]-Vasopressin. An anti-diuretic peptide hormone. Released from the hypothalamus during stress. Although noted primarily for its hemodynamic and hemostatic properties, it appears to affect the immune system. Acts via the activation of the adenylate cyclase system resulting in increased cAMP levels (EC50 = 34 nM).

Form

Lyophilized

Formulation

Supplied as a trifluoroacetate salt.

CAS number

113-79-1

Chemical formula

C₄₆H₆₅N₁₅O₁₂S₂

Peptide Sequence

H-Cys¹-Tyr-Phe-Gln-Asn-Cys⁶-Pro-Arg-Gly-NH₂ (disulfide bond: 1 → 6)

Purity

≥97% by HPLC

Solubility

H₂O (1 mg/ml)

Storage

-20°CProtect from moisture

Do Not Freeze

Ok to freeze

Special Instructions

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.