Campgrounds and cabins, initially primitive in design, sprang up at roadside during the 1920s and 1930s to accommodate motorcar traffic.

The road runs parallel to the river, and it was well into the morning when the burning motors came to Needles, where the river runs swiftly among the reeds.The Joads and Wilsons drove to the river, and they sat in the cars looking at the lovely water flowing by and the green reeds jerking slowly in the current. There was a little encampment by the river, eleven tents near the water, and the swamp grass on the ground. And Tom leaned out of the truck window. "Mind if we stop here a piece?"

In the 1940 film The Grapes of Wrath, the first sights on entering California were signs for the town of Needles and for "Carty's Camp", a group of tourist cabins (now abandoned and in disrepair) with a filling station.[5] After World War II, increased prosperity meant that travellers who once camped as "tin-can tourists" were now staying in a growing number of roadside motels along the highway.[6] Road travel would replace rail travel for an increasing number of passengers in the 1950s.

66 Motel, built soon after the war, was constructed (1946–47) in front of the historic Carty's cabin camp. In 1949, the old El Garces railway hotel accommodated its last overnight visitors.[1] In its heyday, the 66 Motel (like many other contemporary lodgings) offered air conditioning, TV and kitchenettes with neon signage pointing the way.[7]

The Red Rock Bridge, a former railway bridge, carried Route 66 traffic across the Colorado River from 1946 until the Interstate 40 crossing was built two decades later.[8] I-40 bypassed Needles c. 1970[1] and the long-abandoned Red Rock Bridge was dismantled in 1976, leaving I-40 as the only viable highway crossing eastward into Arizona.[8] An 11-mile stretch of US 95 through Needles was also pushed out of the town onto I-40 as part of a concurrency.

This left the motel and the Route 66 segment through the village bypassed and no longer part of the main road westward to Los Angeles.

66 Motel neon sign before restoration

Small independent Route 66 lodgings, on the town's now-bypassed main street but a mile or more from the nearest freeway exit, would be forced to compete with national chains building newer, larger properties directly adjacent to the I-40 off-ramps.

"This has been a dead place for a long time, This motel has a lot of potential, but what it boils down to is that Mama-and-Papa businesses in this country are dead, dead, dead. You need big business to do anything. All I want to do is get out of here."

As the small, independent motels relied on the visibility which came with a location on the main road of their era, business declined. By the 1990s, the 66 Motel was no longer taking overnight travellers and its much-photographed neon signage was deteriorating and no longer functional. The motel survived through monthly rentals as single room occupancy.

In 2012, a private fundraising effort led by Ed Klein of Route 66 World raised almost three thousand dollars ($3000) toward the repair of the historic motel's neon signage;[9] the green 66 and red MOTEL flickered back to life as part of a re-lighting ceremony on the evening of June 23, 2012.
Klein has plans to revisit the motel sign in the first half of 2018 to give it a touch up of paint and to check the neon's electrical system.