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Backsground : In many countries especially in Africa and Southeast Asia including Indonesia. Malaria disease especially malaria falciparum is still a great problem causing high mortality rate. A lot of antimalarial drugs available now a days are resistant. To solve the antimalarial drug resistancy, several studies, invitro and invivo are kept on attempted in order to find novel antimalarial drugs, some of them are Herbal medicine used in community included sambiloto (Andrograpees paniculata Nees)
Aim : To evaluate the effectively of single Herba Sambiloto Extract 250 mg as an antimalarial drug in uncomplicated malaria falciparum.
Methods : This study was being conducted in 50 patients fulfilled inclusion criteria, and then randomly given numberized drugs, divided in two groups, group I was given Sambiloto capsules 250 mg (each capsule contains Sambiloto Extract 250 mg (ES250)) and placebo Sambiloto capsule three times a day per oral for five days. Besides that, they were also given four capsules placebo Choloroquine on the first and second day, and two capsules of placebo Choloroquine on the third day, per oral. Group II, was given Sambiloto capsule placebo three times a day for five days per oral. Besides that, they were also taken four capsules of Choloroquine base 150 mg on the first day and the second day, and two capsules of Choloroquine base 150 on the third day per oral. Parasite density was evaluated on days 0, 1, 2, 3, 4, 5, 6, 7 and then on days 14, 21, and 28.
Results : Of 50 subjects, there are 21 subjects on ES250 groups who were still being followed until the end of the priod, while there are 20 subjects in ES 250 group. The most common patients complaint was myalgia (88%), and the least was diarrhea (8%). Parasite Clearance Time in ES250 group and ES250+K groups were started from day 7 and did not differ significantly between the two groups. Efficacy of the tested drugs in both groups was more than 90% and did not differ significantly. The most common side effect in both groups was nausea (16%), and the least was shivering (2%).
Conclusion : Herba Sambiloto Extract capsule 250 mg is effective as an antimalarial drug.