In percent concentration of inhaled gas

How do all volatiles effect SVR & myocardial function?

Vasodilation & myocardial depression

The most hemodynamically stable pharmacodynamics?

Nitrous Oxide

Isoflurane

Longest on/off but fewest cardiac side effects and least expensive, good for long cases

5

Desflurane

Shortest on/off but airway irritant

6

Sevoflurane

Causes the least airway irritation and can be used for induction of anesthesia

7

Nitrous Oxide - when to avoid?

Readily diffuses into closed air spaces. Should be avoided in situations where an increase in volume of pressure of an enclosed space is undesired - i.e. middle ear surgery, bowel obstruction, pneumothorax

8

MAC

Partial pressure of inhaled anesthetic which prevents movement in response to surgical incision in 50% of the population