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Hardware development for an optical "PET"

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​Project type: BSc thesis / MSc thesis / semester project

Abstract:A miniaturized FMT with compact design and easy handling is certainly attractive. This calls for the integration of a MEMS chip. The aim of the thesis is to integrate a MEMS chip into the current FMT design with stable power supply. Previously, we have developed a compact FMT/MRI hybrid system, which serves as a starting point for the project.

Keywords: MEMS, Fluorescence tomography, optical imaging

Date: Earliest starting date is Sep 1, 2018

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Fluorescence molecular tomography (FMT) provides molecular information on tracer bio-distribution in the organism similar to positron emission tomography (PET). Instead of using radioactive tracers in PET, FMT non-invasively resolves the three-dimensional distribution of fluorescent probes in vivo. Thus, it can be considered an optical version of PET (but only 1% cost of PET). Although both image reconstruction algorithms and instrumentation for FMT have evolved over the past decade, none of the setups has been widely accepted as a standard molecular imaging tool for routine biomedical research.

The project will be carried out in The Biomedical Optics Research Laboratory (BORL) at University Hospital Zurich and Animal Imaging Center (AIC) at ETH Zurich. BORL is focused on the development of diagnostic tools using light and their research or clinical application. AIC provides access to complementary imaging modalities in rodents within one single facility including Magnetic resonance imaging and spectrosopy, Fluorescence imaging, Two-photon microscopy and Micro X-ray.

Goal:1. Integration of a MEMS chip;2. Installation of proper power supply;3. Performance evaluation with silicone phantom.

Qualifications:
Students with background of applied optics, electronical engineering,
mechanical engineering or biomedical engineering are encouraged to
apply.