Cytosolic NADP-specific isocitrate dehydrogenase, catalyzes oxidation of isocitrate to alpha-ketoglutarate; levels are elevated during growth on non-fermentable carbon sources and reduced during growth on glucose; May function in the production of NADPH for fatty acid and sterol synthesis (412 aa)

Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes; Mitochondrial IDP1 may regulate flux through the tricarboxylic acid cycle and respiration. Its probably critical function is the production of NADPH (428 aa)

0.963

AAT1

Mitochondrial aspartate aminotransferase, catalyzes the conversion of oxaloacetate to aspartate in aspartate and asparagine biosynthesis; Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol (By similarity) (451 aa)

a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1

node2

node1 accession

node2 accession

node1 annotation

node2 annotation

score

AAT1

ALT1

YKL106W

YLR089C

Mitochondrial aspartate aminotransferase, catalyzes the conversion of oxaloacetate to aspartate in aspartate and asparagine biosynthesis; Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol (By similarity)

Mitochondrial aspartate aminotransferase, catalyzes the conversion of oxaloacetate to aspartate in aspartate and asparagine biosynthesis; Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol (By similarity)

Putative alanine transaminase (glutamic pyruvic transaminase)

0.923

AAT1

GAD1

YKL106W

YMR250W

Mitochondrial aspartate aminotransferase, catalyzes the conversion of oxaloacetate to aspartate in aspartate and asparagine biosynthesis; Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol (By similarity)

Mitochondrial aspartate aminotransferase, catalyzes the conversion of oxaloacetate to aspartate in aspartate and asparagine biosynthesis; Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol (By similarity)

Mitochondrial aspartate aminotransferase, catalyzes the conversion of oxaloacetate to aspartate in aspartate and asparagine biosynthesis; Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol (By similarity)

Mitochondrial aspartate aminotransferase, catalyzes the conversion of oxaloacetate to aspartate in aspartate and asparagine biosynthesis; Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol (By similarity)

Mitochondrial aspartate aminotransferase, catalyzes the conversion of oxaloacetate to aspartate in aspartate and asparagine biosynthesis; Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol (By similarity)

Glutamine synthetase (GS), synthesizes glutamine from glutamate and ammonia; with Glt1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source and by amino acid limitation

0.409

AAT1

GLT1

YKL106W

YDL171C

Mitochondrial aspartate aminotransferase, catalyzes the conversion of oxaloacetate to aspartate in aspartate and asparagine biosynthesis; Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol (By similarity)

NAD(+)-dependent glutamate synthase (GOGAT), synthesizes glutamate from glutamine and alpha-ketoglutarate; with Gln1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source; Forms L-glutamate from L-glutamine and 2-oxoglutarate. Represents an alternative pathway to L-glutamate dehydrogenase for the biosynthesis of L-glutamate. Participates with glutamine synthetase in ammonia assimilation processes. The enzyme is specific for NADH, L-glutamine and 2-oxoglutarate

0.521

AAT1

IDP1

YKL106W

YDL066W

Mitochondrial aspartate aminotransferase, catalyzes the conversion of oxaloacetate to aspartate in aspartate and asparagine biosynthesis; Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol (By similarity)

Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes; Mitochondrial IDP1 may regulate flux through the tricarboxylic acid cycle and respiration. Its probably critical function is the production of NADPH

0.910

AAT1

IDP2

YKL106W

YLR174W

Mitochondrial aspartate aminotransferase, catalyzes the conversion of oxaloacetate to aspartate in aspartate and asparagine biosynthesis; Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol (By similarity)

Cytosolic NADP-specific isocitrate dehydrogenase, catalyzes oxidation of isocitrate to alpha-ketoglutarate; levels are elevated during growth on non-fermentable carbon sources and reduced during growth on glucose; May function in the production of NADPH for fatty acid and sterol synthesis

Mitochondrial aspartate aminotransferase, catalyzes the conversion of oxaloacetate to aspartate in aspartate and asparagine biosynthesis; Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol (By similarity)

NAD(+)-dependent glutamate synthase (GOGAT), synthesizes glutamate from glutamine and alpha-ketoglutarate; with Gln1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source; Forms L-glutamate from L-glutamine and 2-oxoglutarate. Represents an alternative pathway to L-glutamate dehydrogenase for the biosynthesis of L-glutamate. Participates with glutamine synthetase in ammonia assimilation processes. The enzyme is specific for NADH, L-glutamine and 2-oxoglutarate

Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes; Mitochondrial IDP1 may regulate flux through the tricarboxylic acid cycle and respiration. Its probably critical function is the production of NADPH

Cytosolic NADP-specific isocitrate dehydrogenase, catalyzes oxidation of isocitrate to alpha-ketoglutarate; levels are elevated during growth on non-fermentable carbon sources and reduced during growth on glucose; May function in the production of NADPH for fatty acid and sterol synthesis

0.867

ALT2

AAT1

YDR111C

YKL106W

Putative alanine transaminase (glutamic pyruvic transaminase)

Mitochondrial aspartate aminotransferase, catalyzes the conversion of oxaloacetate to aspartate in aspartate and asparagine biosynthesis; Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol (By similarity)

0.923

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Functional enrichments in your networkNote: some enrichments may be expected here (why?)

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Statistical background

For the above enrichment analysis, the following statistical background is assumed: