ORCHARD PARK, N.Y. — Bills rookie quarterback EJ Manuel is closing the season much like he opened it, facing questions about yet another knee injury.

"Tell me about it," Manuel said Wednesday after being ruled out from playing against Miami this weekend because of a swollen left knee. "When it happened in the game, I just said to myself: 'Is this really happening again?' "

Manuel is out after being hurt in a 27-20 win at Jacksonville on Sunday. That leaves journeyman backup Thad Lewis to make his fourth start of the season and second against the AFC East rival Dolphins.