The NMDA Receptor

Second Edition

Edited by G. L. Collingridge and J. C. Watkins

The NMDA Receptor

Second Edition

Edited by G. L. Collingridge and J. C. Watkins

Description

This book comprises an up-to-date and comprehensive coverage of the NMDA receptor. The NMDA receptor is an important protein in the brain which is involved in physiological processes such as synaptic transmission and synaptic plasticity which may underlie learning and memory. Pathological changes involving the NMDA receptors probably contribute to the development of epilepsy, acute neuronal damage such as that resulting from stroke and chronic neuropathologies such as Alzheimer's disease. There is considerable interest in the development of pharmacological agents active at NMDA receptors as new therapeutic agents.

Each chapter in this book has been prepared by a leading expert in the field and has been fully updated to cover recent developments in the molecular biology and the molecular pharmacology of the NMDA receptor. This is the only book of its kind in the world.

The NMDA Receptor

Second Edition

Edited by G. L. Collingridge and J. C. Watkins

Table of Contents

1. The NMDA receptor concept: origins and development2. Agonists and competitive antagonists: structure, activity and molecular modelling studies3. Non-competitive antagonists of N-methyl-D-aspartate4. Molecular pharmacology of NMDA receptors5. Molecular biology of NMDA receptors6. Anatomical, pharmacological, and molecular diversity of native NMDA receptor subtypes7. The NMDA receptor, its channel, and its modulation by glycine8. The time-course of NMDA receptor-mediated synaptic currents9. Activation of NMDA receptors10. NMDA receptors and their interactions with other excitatory amino acid receptors in synaptic transmission in the mammalian central nervous system11. The importance of NMDA receptors in the processing of spinal primary afferent input patterns12. The role of NMDA receptors in synaptic integration and the organization of motor patterns13. NMDA receptors and long-term potentiation in the hippocampus14. NMDA receptors and developmental plasticity in visual neocortex15. The role of NMDA receptors in learning and memory16. Clinical implications of NMDA receptors17. The NMDA receptor in epilepsy18. NMDA receptors, neuronal development, and neurodegeneration19. Competitive NMDA antagonists as drugs20. Non-competitive NMDA antagonists as drugs

The NMDA Receptor

Second Edition

Edited by G. L. Collingridge and J. C. Watkins

Reviews and Awards

"Provides several chapters that deal with the clinical implications of the experimental findings presented. The discussion of the potential uses of these agents in human disease is complete and provides a starting point in understanding the rationale of their use in clinical trials."--The Annals of Pharmacotherapy