Pitrm1 is expressed in Pax3 (zeige PAX3 Antikörper)-expressing myoblast progenitors in the limb, the dermomyotome, and developing muscles of the face and torso.

PITRM1 Antigen-Profil

Beschreibung des Gens

ATP-independent protease that degrades mitochondrial transit peptides after their cleavage. Also degrades other unstructured peptides. Specific for peptides in the range of 10 to 65 residues. Able to degrade amyloid beta A4 (APP) protein when it accumulates in mitochondrion, suggesting a link with Alzheimer disease. Shows a preference for cleavage after small polar residues and before basic residues, but without any positional preference.