Palliative and Supportive care

EGFRI-Related Skin Toxicity

Information, treatment algorithms and educational materials for healthcare professionals and patients about skin problems that may occur when being treated with anti-EGFR drugs

Multikinase Inhibitor Related Skin Toxicity

Information, treatment algorithms and educational materials for healthcare professionals and patients relating to the management of dermatological toxicities in patients treated with multikinase inhibitors.

Drug-Drug Interactions with Kinase Inhibitors

Information and education online resource for healthcare professionals on drug-drug interactions which can arise from the use of kinase inhibitors

Adenocarcinomas account for 20%–25% of cervical cancers and are difficult to detect by screening. Most are HPV cancers and HPV18 is frequent. Histological types include endocervical and mucinous; mixed adenosquamous carcinomas may occur.

Small cell undifferentiated carcinoma is the least frequent, but a highly aggressive, HPV cancer.

A few adenocarcinomas are not HPVrelated; they include gastric type mucinous and clear cell adenocarcinoma and adenocarcinoma arising from mesonephric remnants.

Revision Questions

Why is the incidence of cervical cancer in developed countries decreasing? What is a promising discovery for reducing cervical cancer incidence even in developing countries?

What are the most common, high-risk HPVs related to invasive cervical cancer? What is the molecular pathogenesis?