It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

It is not known whether dupilumab passes into breast milk or if it could affect the nursing baby. Tell your doctor if you are breast-feeding.

Dupilumab is not approved for use by anyone younger than 18 years old.

How should I use dupilumab?

Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.

Dupilumab is injected under the skin. You may be shown how to use injections at home. Do not give yourself this medicine if you do not understand how to use the injection and properly dispose of used needles and syringes.

Dupilumab is usually given once every other week. Your first dose may be given in 2 injections. Follow your doctor's dosing instructions very carefully.

Your care provider will show you the best places on your body to inject dupilumab. Use a different place each time you give an injection. Do not inject into the same place two times in a row.

Store prefilled syringes in their original carton in the refrigerator. Protect from light and do not allow the medicine to freeze.

Take a syringe out of the refrigerator and allow it to reach room temperature for 45 minutes before injecting your dose. Leave the needle cap on the syringe until you are ready to inject your dose.

Do not shake the prefilled syringe. Prepare your dose only when you are ready to give an injection. Do not use if the medicine has changed colors or has particles in it. Call your pharmacist for new medicine.

Each single-use prefilled syringe of dupilumab is for one use only. Throw away after one use, even if there is still some medicine left in it after injecting your dose.

You may store a prefilled syringe for up to 14 days at cool room temperature. Do not put a syringe back in the refrigerator if you have not used the syringe within 14 days.

Use a disposable needle and syringe only once. Follow any state or local laws about throwing away used needles and syringes. Use a puncture-proof "sharps" disposal container (ask your pharmacist where to get one and how to throw it away). Keep this container out of the reach of children and pets.

If you also use asthma medication, do not change your doses or medication schedule without your doctor's advice.

What happens if I miss a dose?

Use the missed dose as soon as you remember, or within 7 days after it was scheduled. If you are more than 7 days late, skip the missed dose. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while using dupilumab?

Follow your doctor's instructions about using any topical skin medications while you are using dupilumab.

Do not receive a "live" vaccine while using dupilumab. The vaccine may not work as well during this time, and may not fully protect you from disease. Live vaccines include measles, mumps, rubella (MMR), polio, rotavirus, typhoid, yellow fever, varicella (chickenpox), zoster (shingles), and nasal flu (influenza) vaccine.

Dupilumab side effects

Get emergency medical help if you have signs of an allergic reaction:hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Dupilumab dosing information

Comments:-This drug can be used with or without topical corticosteroids.-Topical calcineurin inhibitors may be used, but should be reserved for problem areas only (i.e., face, neck, intertriginous and genital areas). -If a dose is missed, it should be administered within 7 days from the missed dose and then resume the original schedule. If the missed dose is not administered within 7 days, it should be skipped until the next dose on the original schedule.

Use: For moderate-to-severe atopic dermatitis not adequately controlled with topical prescription therapies or when those therapies are not advisable

What other drugs will affect dupilumab?

Other drugs may interact with dupilumab, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.