Therapeutic Use:

Indications for FIORINAL:

Adult:

Use lowest effective dose for shortest duration. 1–2 caps every 4hrs, as needed; max 6 caps/day. Also with Codeine: concomitant use or discontinuation of CYP2D6 inhibitors, CYP3A4 inhibitors or inducers: monitor closely and consider dose adjustments (see full labeling). Withdraw gradually by 25–50% every 2–4 days.

Children:

Not established.

Contraindications:

Hemophilia. Reye's Syndrome. NSAID allergy. Syndrome of asthma, rhinitis, and nasal polyps. Also with Codeine: significant respiratory depression. Acute or severe bronchial asthma in an unmonitored setting or in the absence of resuscitative equipment. Known or suspected GI obstruction, including paralytic ileus. During or within 14 days of MAOIs. Post-op pain management in children who have undergone tonsillectomy and/or adenoidectomy.