MicroRNAs (miRNAs) are small, non-coding RNAs that negatively regulate gene expression at the post-transcriptional level. In the brain, a large number of miRNAs are expressed and there is a growing body of evidence demonstrating that miRNAs are essential for brain development and neuronal function. Conditional knockout studies of the core components in the miRNA biogenesis pathway, such as Dicer and DGCR8, have demonstrated a crucial role for miRNAs during the development of the central nervous system. Furthermore, mice deleted for specific miRNAs and miRNA-clusters demonstrate diverse functional roles for different miRNAs during the development of different brain structures. miRNAs have been proposed to regulate cellular functions such as differentiation, proliferation and fate-determination of neural progenitors. In this review we summarise the findings from recent studies that highlight the importance of miRNAs in brain development with a focus on the mouse model. We also discuss the technical limitations of current miRNA studies that still limit our understanding of this family of non-coding RNAs and propose the use of novel and refined technologies that are needed in order to fully determine the impact of specific miRNAs in brain development. - Highlights: • miRNAs are essential for brain development and neuronal function. • KO of Dicer is embryonically lethal. • Conditional Dicer KO results in defective proliferation or increased apoptosis. • KO of individual miRNAs or miRNA families is necessary to determine function.

We explore the non-linear dynamics of two parallel periodically patterned metal surfaces that are coupled by the zero-point fluctuations of the electromagnetic field between them. The resulting Casimir force generates for asymmetric patterns with a time-periodically driven surface-to-surface distance a ratchet effect, allowing for directed lateral motion of the surfaces in sizeable parameter ranges. It is crucial to take into account inertia effects and hence chaotic dynamics which are described by Langevin dynamics. Multiple velocity reversals occur as a function of driving, mean surface distance, and effective damping. These transport properties are shown to be stable against weak ambient noise.

Fermilab's Main Injector on acceleration cycles to 120 GeV has been running a mixed mode operation delivering beam to both the antiproton source for pbar production and to the NuMI[1] target for neutrino production since 2005. On January 2008 the slip stacking process used to increase the beam to the pbar target was expanded to include the beam to the NuMI target increasing both the beam intensity and power. The current high power MI operation will be described along with the near future plans.

The original safety assessment and the Safety Envelope for the NuMI beam line corresponds to 400 kW of beam power. The Main Injector is currently capable of and approved for producing 500 kW of beam power2. However, operation of the NuMI beam line at 400 kW of power brings up the possibility of an occasional excursion above 400 kW due to better than usual tuning in one of the machines upstream of the NuMI beam line. An excursion above the DOE approved Safety Envelope will constitute a safety violation. The purpose of this addendum is to evaluate the radiological issues and modifications required to operate the NuMI beam line at 500 kW. This upgrade will allow 400 kW operations with a reasonable safety margin. Configuration of the NuMI beam line, boundaries, safety system and the methodologies used for the calculations are as described in the original NuMI SAD. While most of the calculations presented in the original shielding assessment were based on Monte Carlo simulations, which were based on the design geometries, most of the results presented in this addendum are based on the measurements conducted by the AD ES&H radiation safety group.

The kicker system requirements were originally conceived for the NOvA project. NOvA is a neutrino experiment located in Minnesota. To achieve the desired neutrino flux several upgrades are required to the accelerator complex. The Recycler will be used as a proton pre-injector for the Main Injector (MI). As the Recycler is the same size as the MI, it is possible to do a single turn fill ({approx}11 {micro}sec), minimizing the proton injection time in the MI cycle and maximizing the protons on target. The Recycler can then be filled with beam while the MI is ramping to extract beam to the target. To do this requires two new transfer lines. The existing Recycler injection line was designed for 10{pi} pbar beams, not the 20{pi} proton beams we anticipate from the Booster. The existing Recycler extraction line allows for proton injection through the MI, while we want direct injection from the Booster. These two lines will be decommissioned. The new injection line from the MI8 line into the Recycler will start at 848 and end with injection kickers at RR104. The new extraction line in the RR30 straight section will start with a new extraction kicker at RR232 and end with new MI injection kickers at MI308. Finally, to reduce beam loss activation in the enclosure, a new gap clearing kicker will be used to extract uncaptured beam created during the slip stack injection process down the existing dump line. It was suggested that the MI could benefit from this type of system immediately. This led to the early installation of the gap clearing system in the MI, followed by moving the system to Recycler during NOvA. The specifications also changed during this process. Initially the rise and fall time requirements were 38 ns and the field stability was {+-}1%. The 38 ns is based on having a gap of 2 RF buckets between injections. (There are 84 RF buckets that can be filled from the Booster for each injection, but 82 would be filled with beam. MI and Recycler contain 588 RF buckets.) A rough cost/benefit analysis showed that increasing the number of empty buckets to 3 decreased the kicker system cost by {approx}30%. This could be done while not extending the running time since this is only a 1% reduction in protons per pulse, hence the rise and fall time are now 57 ns. Additionally, the {+-}1% tolerance would have required a fast correction kicker while {+-}3% could be achieved without this kicker. The loosened tolerance was based on experience on wide band damping systems in the MI. A higher power wideband damping system is a better use of the resources as it can be used to correct for multiple sources of emittance growth. Finally, with the use of this system for MI instead of Recycler, the required strength grew from 1.2 mrad to 1.7 mrad. The final requirements for this kicker are listed.

MicroRNAs (miRNAs) are short RNAs that regulate many processes in physiology and pathology by guiding the repression of target messenger RNAs. For classification purposes, miRNAs are defined as ~22 nt RNAs that are produced ...

Research highlights: {yields} The expression of miR-132 and miR-212 are significantly increased in pancreatic cancer. {yields} miR-132 and miR-212 target the tumor suppressor pRb, resulting in enhanced proliferation. {yields} miR-132 and miR-212 expression is increased by a {beta}2 adrenergic receptor agonist, suggesting a novel mechanism for pancreatic cancer progression. -- Abstract: Numerous microRNAs (miRNAs) are reported as differentially expressed in cancer, however the consequence of miRNA deregulation in cancer is unknown for many miRNAs. We report that two miRNAs located on chromosome 17p13, miR-132 and miR-212, are over-expressed in pancreatic adenocarcinoma (PDAC) tissues. Both miRNAs are predicted to target the retinoblastoma tumor suppressor, Rb1. Validation of this interaction was confirmed by luciferase reporter assay and western blot in a pancreatic cancer cell line transfected with pre-miR-212 and pre-miR-132 oligos. Cell proliferation was enhanced in Panc-1 cells transfected with pre-miR-132/-212 oligos. Conversely, antisense oligos to miR-132/-212 reduced cell proliferation and caused a G{sub 2}/M cell cycle arrest. The mRNA of a number of E2F transcriptional targets were increased in cells over expressing miR-132/-212. Exposing Panc-1 cells to the {beta}2 adrenergic receptor agonist, terbutaline, increased the miR-132 and miR-212 expression by 2- to 4-fold. We report that over-expression of miR-132 and miR-212 result in reduced pRb protein in pancreatic cancer cells and that the increase in cell proliferation from over-expression of these miRNAs is likely due to increased expression of several E2F target genes. The {beta}2 adrenergic pathway may play an important role in this novel mechanism.

-92 cluster encodes six miRNAs, miR-17, miR-18a, miR-19a, miR-20a, miR19b-1 and miR-92-1. They are known as oncogenes and play roles in the development of heart, lungs and immune system (Koralov et al., 2008; Ventura et al., 2008; Vincentz et al., 2008... previously described (Liu et al., 2004; Ventura et al., 2008; Verzi et al., 2005; Xiao et al., 2008). To generate the Bmp7flox allele, a targeting vector was constructed that introduced one loxP site into upstream of the Bmp7 fourth exon followed by a frt...

Cilibrasi and Vitanyi have demonstrated that it is possible to extract the meaning of words from the world-wide web. To achieve this, they rely on the number of webpages that are found through a Google search containing a given word and they associate the page count to the probability that the word appears on a webpage. Thus, conditional probabilities allow them to correlate one word with another word's meaning. Furthermore, they have developed a similarity distance function that gauges how closely related a pair of words is. We present a specific counterexample to the triangle inequality for this similarity distance function.

of miR-34a expression may be responsible for important protective mechanisms counteracting radiationOPEN Repression of ATR pathway by miR-185 enhances radiation-induced apoptosis and proliferation of a human microRNA (miRNA), hsa-miR-185, is downregulated in response to ionizing radiation. Elevation of mi

microRNAs (miRNA) are a class of non-protein coding functional RNAs that are thought to regulate expression of target genes by direct interaction with mRNAs. miRNAs have been identified through both experimental and computational methods in a variety of eukaryotic organisms. Though these approaches have been partially successful, there is a need to develop more tools for detection of these RNAs as they are also thought to be present in abundance in many genomes. In this report we describe a tool and a web server, named CID-miRNA, for identification of miRNA precursors in a given DNA sequence, utilising secondary structure-based filtering systems and an algorithm based on stochastic context free grammar trained on human miRNAs. CID-miRNA analyses a given sequence using a web interface, for presence of putative miRNA precursors and the generated output lists all the potential regions that can form miRNA-like structures. It can also scan large genomic sequences for the presence of potential miRNA precursors in its stand-alone form. The web server can be accessed at (http://mirna.jnu.ac.in/cidmirna/)

MicroRNA miR-125b has been implicated in several kinds of leukemia. The chromosomal translocation t(2;11)(p21;q23) found in patients with myelodysplasia and acute myeloid leukemia leads to an overexpression of miR-125b of ...

. Abstract Background: Small non-coding RNAs (21 to 24 nucleotides) regulate a number of developmental the collection of currently known soybean miRNAs. We developed a bioinformatics pipeline using in-house scripts on regulation patterns between the miRNAs and their predicted target genes expression. We also deposited

MicroRNAs (miRNAs) are noncoding RNAs that suppress translation of specific mRNAs. The miRNA machinery interacts with fragile X mental retardation protein (FMRP), which functions as translational repressor. We show that ...

-learning on college level. One of the main problems is that study material as well as concepts have to be transformed component of the Open Source movement. Key words: distance learning, open source 1. INTRODUCTORY REMARKS of each semester. 2. THE CORE PROBLEM WHEN USING E-LEARNING-TOOLS IN DISTANCE LEARNING Most people

An Energy-Driven Approach to Linkage Unfolding Jason H. Cantarella Erik D. Demaine Hayley N. Iben in the original linkage and expanding all distances between pairs of vertices. The alternative approach of [4 these snapshots remains opaque. 2 Our Results. In this paper, we introduce a new energy-driven approach

Executive Summary The energy development assumptions identified in the Department of Energy's position paper, 20% Wind Energy by 2030, projected an exploding demand for wind energy-related workforce development. These primary assumptions drove a secondary set of assumptions that early stage wind industry workforce development and training paradigms would need to undergo significant change if the workforce needs were to be met. The current training practice and culture within the wind industry is driven by a relatively small number of experts with deep field experience and knowledge. The current training methodology is dominated by face-to-face, classroom based, instructor present training. Given these assumptions and learning paradigms, the purpose of the National Wind Distance Learning Collaborative was to determine the feasibility of developing online learning strategies and products focused on training wind technicians. The initial project scope centered on (1) identifying resources that would be needed for development of subject matter and course design/delivery strategies for industry-based (non-academic) training, and (2) development of an appropriate Learning Management System (LMS). As the project unfolded, the initial scope was expanded to include development of learning products and the addition of an academic-based training partner. The core partners included two training entities, industry-based Airstreams Renewables and academic-based Lake Area Technical Institute. A third partner, Vision Video Interactive, Inc. provided technology-based learning platforms (hardware and software). The revised scope yielded an expanded set of results beyond the initial expectation. Eight learning modules were developed for the industry-based Electrical Safety course. These modules were subsequently redesigned and repurposed for test application in an academic setting. Software and hardware developments during the project's timeframe enabled redesign providing for student access through the use of tablet devices such as iPads. Early prototype Learning Management Systems (LMS) featuring more student-centric access and interfaces with emerging social media were developed and utilized during the testing applications. The project also produced soft results involving cross learning between and among the partners regarding subject matter expertise, online learning pedagogy, and eLearning technology-based platforms. The partners believe that the most significant, overarching accomplishment of the project was the development and implementation of goals, activities, and outcomes that significantly exceeded those proposed in the initial grant application submitted in 2009. Key specific accomplishments include: (1) development of a set of 8 online learning modules addressing electrical safety as it relates to the work of wind technicians; (3) development of a flexible, open-ended Learning Management System (LMS): (3) creation of a robust body of learning (knowledge, experience, skills, and relationships). Project leaders have concluded that there is substantial resource equity that could be leverage and recommend that it be carried forward to pursue a Next Stage Opportunity relating to development of an online core curriculum for institute and community college energy workforce development programs.

We present new results on the measurement of correlated, outgoing neutrons from spontaneous fission events in a Cf-252 source. 16 EJ-309 liquid scintillation detectors are used to measure neutron-neutron correlations for various detector angles. Anisotropy in neutron emission is observed. The results are compared to MCNPX-PoliMi simulations and good agreement is observed.

In the past few years, efforts to develop new measurement systems to support nuclear nonproliferation and homeland security have increased substantially. Monte Carlo radiation transport is one of the simulation methods of choice for the analysis of data from existing systems and for the design of new measurement systems; it allows for accurate description of geometries, detailed modeling of particle-nucleus interactions, and event-by-event detection analysis. This paper describes the use of the Monte Carlo code MCNPX-PoliMi for nuclear-nonproliferation applications, with particular emphasis on the simulation of spontaneous and neutron-induced nuclear fission. In fact, of all possible neutron-nucleus interactions, neutron-induced fission is the most defining characteristic of special nuclear material (such as U-235 and Pu-239), which is the material of interest in nuclear-nonproliferation applications. The MCNP-PoliMi code was originally released from the Radiation Safety Shielding Center (RSSIC) at Oak Ridge National Laboratory in 2003 [1]; the MCNPX-PoliMi code contains many enhancements and is based on MCNPX ver. 2.7.0. MCNPX-PoliMi ver. 2.0 was released through RSICC in 2012 as a patch to MCNPX ver. 2.7.0 and as an executable [2].

Neutrino interaction rates for experiments placed off axis in the NuMI beam are calculated. Primary proton beam energy is 120 GeV and four locations at 810 km from target and 6, 12, 30 and 40 km off axis are considered. This report is part of the Joint FNAL/BNL Future Long Baseline Neutrino Oscillation Experiment Study.

The genomes of plants and animals encode hundreds of non-coding ~22nt RNAs termed "microRNAs" (miRNAs). These RNAs guide the sequence-specific inhibition of translation and destabilization of mRNA targets through short ...

Disclosed is a long working distance interference microscope suitable for three-dimensional imaging and metrology of MEMS devices and test structures on a standard microelectronics probe station. The long working distance of 10-30 mm allows standard probes or probe cards to be used. This enables nanometer-scale 3-D height profiles of MEMS test structures to be acquired across an entire wafer. A well-matched pair of reference/sample objectives is not required, significantly reducing the cost of this microscope, as compared to a Linnik microinterferometer.

We study a curve of Gibbsian families of complex 3 Multiplication-Sign 3-matrices and point out new features, absent in commutative finite-dimensional algebras: a discontinuous maximum-entropy inference, a discontinuous entropy distance, and non-exposed faces of the mean value set. We analyze these problems from various aspects including convex geometry, topology, and information geometry. This research is motivated by a theory of infomax principles, where we contribute by computing first order optimality conditions of the entropy distance.

One characteristic feature of soft matter systems is their strong response to external stimuli. As a consequence they are comparatively easily driven out of their ground state and out of equilibrium, which leads to many of their fascinating properties. Here, we review illustrative examples. This review is structured by an increasing distance from the equilibrium ground state. On each level, examples of increasing degree of complexity are considered. In detail, we first consider systems that are quasi-statically tuned or switched to a new state by applying external fields. These are common liquid crystals, liquid crystalline elastomers, or ferrogels and magnetic elastomers. Next, we concentrate on systems steadily driven from outside e.g. by an imposed flow field. In our case, we review the reaction of nematic liquid crystals, of bulk-filling periodically modulated structures such as block copolymers, and of localized vesicular objects to an imposed shear flow. Finally, we focus on systems that are "active" and "self-driven". Here our range spans from idealized self-propelled point particles, via sterically interacting particles like granular hoppers, via microswimmers such as self-phoretically driven artificial Janus particles or biological microorganisms, via deformable self-propelled particles like droplets, up to the collective behavior of insects, fish, and birds. As we emphasize, similarities emerge in the features and behavior of systems that at first glance may not necessarily appear related. We thus hope that our overview will further stimulate the search for basic unifying principles underlying the physics of these soft materials out of their equilibrium ground state.

This paper describes an invention which relates to microtechnology and the fabrication process for developing microelectrical systems. It describes a means for fabricating a gas-driven microturbine capable of providing autonomous propulsion in which the rapidly moving gases are directed through a micromachined turbine to power devices by direct linkage or turbo-electric generators components in a domain ranging from tenths of micrometers to thousands of micrometers.

Distance measures are important for scientists because they illustrate the dynamics of geospatial topologies for physical and social processes. Two major types of distance are generally used for this purpose: Euclidean ...

The physics requirements for the long base line neutrino oscillation experiment MINOS dictate that the NuMI beamline be located in the aquifer at Fermilab. A methodology is described for calculating the level of radioactivation of groundwater caused by operation of this beamline. A conceptual shielding design for the 750 meter long decay pipe is investigated which would reduce radioactivation of the groundwater to below government standards. More economical shielding designs to meet these requirements are being explored. Also, information on local geology, hydrogeology, government standards, and a glossary have been included.

Accurate distances to pulsars can be used for a variety of studies of the Galaxy and its electron content. However, most distance measures to pulsars have been derived from the absorption (or lack thereof) of pulsar emission by Galactic H I gas, which typically implies that only upper or lower limits on the pulsar distance are available. We present a critical analysis of all measured H I distance limits to pulsars and other neutron stars, and translate these limits into actual distance estimates through a likelihood analysis that simultaneously corrects for statistical biases. We also apply this analysis to parallax measurements of pulsars in order to obtain accurate distance estimates and find that the parallax and H I distance measurements are biased in different ways, because of differences in the sampled populations. Parallax measurements typically underestimate a pulsar's distance because of the limited distance to which this technique works and the consequential strong effect of the Galactic pulsar distribution (i.e., the original Lutz-Kelker bias), in H I distance limits, however, the luminosity bias dominates the Lutz-Kelker effect, leading to overestimated distances because the bright pulsars on which this technique is applicable are more likely to be nearby given their brightness.

find distances to celestial objects? Build up distance scale from direct measurements to nearby objectsHubble's Law and the Distance Scale Landmarks in our understanding of cosmic distances: (1) Triangulation to determine the scale and dynamics of the solar system (Kepler) (2) Parallax to determine

. An Energy-Driven Approach to Linkage Unfolding Jason H. Cantarella Erik D. Demaine Hayley N. Iben James F. O and expanding all distances between pairs of vertices. The alternative approach of [4] leads to a more opaque. 2 Our Results. In this paper, we introduce a new energy-driven approach to straightening arcs

In a method of generating electricity, a plurality of living cells are grown on an array of piezoelectric nanowires so that the cells engage the piezoelectric nanowires. Induced static potentials are extracted from at least one of the piezoelectric nanowires when at least one of the cells deforms the at least one of the piezoelectric nanowires. A cell-driven electrical generator that includes a substrate and a plurality of spaced-apart piezoelectric nanowires disposed on the substrate. A plurality of spaced-apart conductive electrodes interact with the plurality of piezoelectric nanowires. A biological buffer layer that is configured to promote growth of cells is disposed on the substrate so that cells placed on the substrate will grow and engage the piezoelectric nanowires.

Global identification of miRNAs and targets in Populus euphratica under salt stress Bosheng Li, a typical hydro-halophyte, is ideal for studying salt stress responses in woody plants. MicroRNAs (miRNA may regulate tolerance to salt stress but this has not been widely studied in P. euphratica

A system and method of efficiently obtaining distance measurements of a target. A modulated optical beam may be used to determine the distance to the target. A first beam splitter may be used to split the optical beam and a second beam splitter may be used to recombine a reference beam with a return ranging beam. An optical mixing detector may be used in a receiver to efficiently detect distance measurement information.

that little or no recruitment occurred in cer- tain parts of the target study areas [7-9]. Despite this, to our knowledge no other RDS studies have looked in detail at how the locations of recruits’ residencies affected recruitment, perhaps due... potentially reduce this problem. Our study was carried out in a rural area where the majority of people work as farmers. This is in contrast to many RDS studies which are carried out in towns or cities. In these settings, travel times using available transport...

An apparatus is described comprising a pair of fluid driven pump assemblies in a back-to-back configuration to yield a bi-directional pump. Each of the pump assemblies includes a piston or diaphragm which divides a chamber therein to define a power section and a pumping section. An intake-exhaust valve is connected to each of the power sections of the pump chambers, and function to direct fluid, such as compressed air, into the power section and exhaust fluid therefrom. At least one of the pistons or diaphragms is connected by a rod assembly which is constructed to define a signal valve, whereby the intake-exhaust valve of one pump assembly is controlled by the position or location of the piston or diaphragm in the other pump assembly through the operation of the rod assembly signal valve. Each of the pumping sections of the pump assemblies are provided with intake and exhaust valves to enable filling of the pumping section with fluid and discharging fluid therefrom when a desired pressure has been reached. 13 figs.

An apparatus comprising a pair of fluid driven pump assemblies in a back-to-back configuration to yield a bi-directional pump. Each of the pump assemblies includes a piston or diaphragm which divides a chamber therein to define a power section and a pumping section. An intake-exhaust valve is connected to each of the power sections of the pump chambers, and function to direct fluid, such as compressed air, into the power section and exhaust fluid therefrom. At least one of the pistons or diaphragms is connected by a rod assembly which is constructed to define a signal valve, whereby the intake-exhaust valve of one pump assembly is controlled by the position or location of the piston or diaphragm in the other pump assembly through the operation of the rod assembly signal valve. Each of the pumping sections of the pump assemblies are provided with intake and exhaust valves to enable filling of the pumping section with fluid and discharging fluid therefrom when a desired pressure has been reached.

We investigate similarities in the micro-structural dynamics between externally driven and actively driven nematics. Walls, lines of strong deformations in the director field, and topological defects are characteristic features of an active nematic. Similar structures form in driven passive nematics when there are inhomogeneities in imposed velocity gradients due to non-linear flow fields or geometrical constraints. Specifically, pressure driven flow of a tumbling passive nematic in an expanding-contracting channel produces walls and defects similar to those seen in active nematics. We also study the response of active nematics to external driving, confirming that imposed shear suppresses the hydrodynamic instabilities. We show that shear fields can lead to wall alignments and the localisation of active turbulence.

We investigate similarities in the micro-structural dynamics between externally driven and actively driven nematics. Walls, lines of strong deformations in the director field, and topological defects are characteristic features of an active nematic. Similar structures form in driven passive nematics when there are inhomogeneities in imposed velocity gradients due to non-linear flow fields or geometrical constraints. Specifically, pressure driven flow of a tumbling passive nematic in an expanding-contracting channel produces walls and defects similar to those seen in active nematics. We also study the response of active nematics to external driving, confirming that imposed shear suppresses the hydrodynamic instabilities. We show that shear fields can lead to wall alignments and the localisation of active turbulence.

Knots and Minimum Distance Energy Rosanna Speller (Dated: May 11, 2008) Professor Elizabeth Denne have least Minimum Distance Energy. I previously showed that the energy is minimized for convex polygons. We hope relating the energy to chords of polygons will be a helpful step towards showing

The Cepheid period-luminosity relation is the primary distance indicator used in most determinations of the Hubble constant. The tip of the red giant branch (TRGB) is an alternative basis. Using the new Australian National University (ANU) SkyMapper Telescope, we calibrate the Tully-Fisher relation in the I band. We find that the TRGB and Cepheid distance scales are consistent.

The salinity driven oceanographic upwelling is maintained in a mariculture device that includes a long main duct in the general shape of a cylinder having perforated cover plates at each end. The mariculture device is suspended vertically in the ocean such that one end of the main duct is in surface water and the other end in relatively deep water that is cold, nutrient rich and relatively fresh in comparison to the surface water which is relatively warm, relatively nutrient deficient and relatively saline. A plurality of elongated flow segregating tubes are disposed in the main duct and extend from the upper cover plate beyond the lower cover plate into a lower manifold plate. The lower manifold plate is spaced from the lower cover plate to define a deep water fluid flow path to the interior space of the main duct. Spacer tubes extend from the upper cover plate and communicate with the interior space of the main duct. The spacer tubes are received in an upper manifold plate spaced from the upper cover plate to define a surface water fluid flow path into the flow segregating tubes. A surface water-deep water counterflow is thus established with deep water flowing upwardly through the main duct interior for discharge beyond the upper manifold plate while surface water flows downwardly through the flow segregating tubes for discharge below the lower manifold plate. During such counterflow heat is transferred from the downflowing warm water to the upflowing cold water. The flow is maintained by the difference in density between the deep water and the surface water due to their differences in salinity. The upwelling of nutrient rich deep water is used for marifarming by fertilizing the nutrient deficient surface water. 1 fig.

We present lattice studies of heavy quark potentials in the quenched approximation of QCD at finite temperatures. Both, the color singlet and color averaged potentials are calculated. While the potentials are well known at large distances, we give a detailed analysis of their short distance behavior (from 0.015 fm to 1 fm) near the critical temperature. At these distances we expect that the T-dependent potentials go over into the zero temperature potential. Indeed, we find evidences that the temperature influence gets suppressed and the potentials starts to become a unique function of the underlying distance scale. We use this feature to normalize the heavy quark potentials at short distances and extract the free energy of the quark system in a gluonic heat bath.

Solar flares are the most powerful events in the solar system and the brightest sources of X-rays, often associated with emission of particles reaching the Earth and causing geomagnetic storms, giving problems to communication, airplanes and even black-outs. X-rays emitted by accelerated electrons are the most direct probe of solar flare phenomena. The Micro Solar-Flare Apparatus (MiSolFA) is a proposed compact X-ray detector which will address the two biggest issues in solar flare modeling. Dynamic range limitations prevent simultaneous spectroscopy with a single instrument of all X-ray emitting regions of a flare. In addition, most X-ray observations so far are inconsistent with the high anisotropy predicted by the models usually adopted for solar flares. Operated at the same time as the STIX instrument of the ESA Solar Orbiter mission, at the next solar maximum (2020), they will have the unique opportunity to look at the same flare from two different directions: Solar Orbiter gets very close to the Sun wit...

regulators of gene expression in a wide range of organisms and biological processes. Each miRNA guides Argonaute (Ago) protein complexes to target and repress hundreds of genes in a sequence-dependent manner. To identify ...

A system and method of efficiently obtaining distance measurements of a target by scanning the target. An optical beam is provided by a light source and modulated by a frequency source. The modulated optical beam is transmitted to an acousto-optical deflector capable of changing the angle of the optical beam in a predetermined manner to produce an output for scanning the target. In operation, reflected or diffused light from the target may be received by a detector and transmitted to a controller configured to calculate the distance to the target as well as the measurement uncertainty in calculating the distance to the target.

Globular clusters are among the first objects used to establish the distance scale of the Universe. In the 1970-ies it has been recognized that the differential magnitude distribution of old globular clusters is very similar in different galaxies presenting a peak at M_V ~ -7.5. This peak magnitude of the so-called Globular Cluster Luminosity Function has been then established as a secondary distance indicator. The intrinsic accuracy of the method has been estimated to be of the order of ~0.2 mag, competitive with other distance determination methods. Lately the study of the Globular Cluster Systems has been used more as a tool for galaxy formation and evolution, and less so for distance determinations. Nevertheless, the collection of homogeneous and large datasets with the ACS on board HST presented new insights on the usefulness of the Globular Cluster Luminosity Function as distance indicator. I discuss here recent results based on observational and theoretical studies, which show that this distance indica...

We studied the efficiency of two different schemes for a magnetically driven quantum heat engine, by considering as the working substance a single nonrelativistic particle trapped in a cylindrical potential well, in the presence of an external magnetic field. The first scheme is a cycle, composed of two adiabatic and two isoenergetic reversible trajectories in configuration space. The trajectories are driven by a quasistatic modulation of the external magnetic-field intensity. The second scheme is a variant of the former, where the isoenergetic trajectories are replaced by isothermal ones, along which the system is in contact with macroscopic thermostats. This second scheme constitutes a quantum analog of the classical Carnot cycle.

Highlights: •miR-196a was overexpressed in cervical cancer tissue compared to normal tissue. •miR-196a expression elevated proliferation and migration of cervical cancer cells. •miR-196a inhibited NTN4 expression by binding 3?-UTR region of NTN4 mRNA. •NTN4 inversely correlated with miR-196a expression in cervical tissue and cell line. •NTN4 expression was low in cervical cancer tissue compared to normal tissue. -- Abstract: Recent research has uncovered tumor-suppressive and oncogenic potential of miR-196a in various tumors. However, the expression and mechanism of its function in cervical cancer remains unclear. In this study, we assess relative expression of miR-196a in cervical premalignant lesions, cervical cancer tissues, and four cancer cell lines using quantitative real-time PCR. CaSki and HeLa cells were treated with miR-196a inhibitors, mimics, or pCDNA/miR-196a to investigate the role of miR-196a in cancer cell proliferation and migration. We demonstrated that miR-196a was overexpressed in cervical intraepithelial neoplasia 2–3 and cervical cancer tissue. Moreover, its expression contributes to the proliferation and migration of cervical cancer cells, whereas inhibiting its expression led to a reduction in proliferation and migration. Five candidate targets of miR-196a chosen by computational prediction and Cervical Cancer Gene Database search were measured for their mRNA in both miR-196a-overexpressing and -depleted cancer cells. Only netrin 4 (NTN4) expression displayed an inverse association with miR-196a. Fluorescent reporter assays revealed that miR-196a inhibited NTN4 expression by targeting one binding site in the 3?-untranslated region (3?-UTR) of NTN4 mRNA. Furthermore, qPCR and Western blot assays verified NTN4 expression was downregulated in cervical cancer tissues compared to normal controls, and in vivo mRNA level of NTN4 inversely correlated with miR-196a expression. In summary, our findings provide new insights about the functional role of miR-196a in cervical carcinogenesis and suggested a potential use of miR-196a for clinical diagnosis and as a therapeutic target.

Highlights: •miR-421 is upregulated in nasopharyngeal carcinoma. •miR-421 induces cell proliferation and apoptosis resistance. •FOXO4 is a direct and functional target of miR-421. -- Abstract: microRNAs have been demonstrated to play important roles in cancer development and progression. Hence, identifying functional microRNAs and better understanding of the underlying molecular mechanisms would provide new clues for the development of targeted cancer therapies. Herein, we reported that a microRNA, miR-421 played an oncogenic role in nasopharyngeal carcinoma. Upregulation of miR-421 induced, whereas inhibition of miR-421 repressed cell proliferation and apoptosis resistance. Furthermore, we found that upregulation of miR-421 inhibited forkhead box protein O4 (FOXO4) signaling pathway following downregulation of p21, p27, Bim and FASL expression by directly targeting FOXO4 3?UTR. Additionally, we demonstrated that FOXO4 expression is critical for miR-421-induced cell growth and apoptosis resistance. Taken together, our findings not only suggest that miR-421 promotes nasopharyngeal carcinoma cell proliferation and anti-apoptosis, but also uncover a novel regulatory mechanism for inactivation of FOXO4 in nasopharyngeal carcinoma.

Recent experimental results on the effect of miRNA on the decay of its target mRNA have been analyzed against a previously hypothesized single molecule degradation pathway. According to that hypothesis, the silencing complex (miRISC) first interacts with its target mRNA and then recruits the protein complexes associated with NOT1 and PAN3 to trigger deadenylation (and subsequent degradation) of the target mRNA. Our analysis of the experimental decay patterns allowed us to refine the structure of the degradation pathways at the single molecule level. Surprisingly, we found that if the previously hypothesized network was correct, only about 7% of the target mRNA would be regulated by the miRNA mechanism, which is inconsistent with the available knowledge. Based on systematic data analysis, we propose the alternative hypothesis that NOT1 interacts with miRISC before binding to the target mRNA. Moreover, we show that when miRISC binds alone to the target mRNA, the mRNA is degraded more slowly, probably through a deadenylation-independent pathway. The new biochemical pathway we propose both fits the data and paves the way for new experimental work to identify new interactions.

One of Jefferson Lab's original missions was to further our understanding of the short-distance structure of nuclei. In particular, to understand what happens when two or more nucleons within a nucleus have strongly overlapping wave-functions; a phenomena commonly referred to as short-range correlations. Herein, we review the results of the (e,e'), (e,e'p) and (e,e'pN) reactions that have been used at Jefferson Lab to probe this short-distance structure as well as provide an outlook for future experiments.

This thesis presents the results of an analysis of {nu}{sub {mu}} disappearance with the MINOS experiment, which studies the neutrino beam produced by the NuMI facility at Fermi National Accelerator Laboratory. The rates and energy spectra of charged current {nu}{sub {mu}} interactions are measured in two similar detectors, located at distances of 1 km and 735 km along the NuMI beamline. The Near Detector provides accurate measurements of the initial beam composition and energy, while the Far Detector is sensitive to the effects of neutrino oscillations. The analysis uses data collected between May 2005 and March 2007, corresponding to an exposure of 2.5 x 10{sup 20} protons on target. As part of the analysis, sophisticated software was developed to identify muon tracks in the detectors and to reconstruct muon kinematics. Events with reconstructed tracks were then analyzed using a multivariate technique to efficiently isolate a pure sample of charged current {nu}{sub {mu}} events. An extrapolation method was also developed, which produces accurate predictions of the Far Detector neutrino energy spectrum, based on data collected at the Near Detector. Finally, several techniques to improve the sensitivity of an oscillation measurement were implemented, and a full study of the systematic uncertainties was performed. Extrapolating from observations at the Near Detector, 733 {+-} 29 Far Detector events were expected in the absence of oscillations, but only 563 events were observed. This deficit in event rate corresponds to a significance of 4.3 standard deviations. The deficit is energy dependent and clear distortion of the Far Detector energy spectrum is observed. A maximum likelihood analysis, which fully accounts for systematic uncertainties, is used to determine the allowed regions for the oscillation parameters and identifies the best fit values as {Delta}m{sub 32}{sup 2} = 2.29{sub -0.14}{sup +0.14} x 10{sup -3} eV{sup 2} and sin{sup 2} 2{theta}{sub 23} > 0.953 (68% confidence level). The models of neutrino decoherence and decay are disfavored at the 5.0{sigma} and 3.2{sigma} levels respectively, while the no oscillation model is excluded at the 9.4{sigma} level.

Pulsed power is a robust and inexpensive technology for obtaining high powers. Considerable progress has been made on developing light ion beams as a means of transporting this power to inertial fusion capsules. However, further progress is hampered by the lack of an adequate ion source. Alternatively, z-pinches can efficiently convert pulsed power into thermal radiation, which can be used to drive an inertial fusion capsule. However, a z-pinch driven fusion explosion will destroy a portion of the transmission line that delivers the electrical power to the z-pinch. They investigate several options for providing standoff for z-pinch driven fusion. Recyclable Transmission Lines (RTLs) appear to be the most promising approach.

Brownian motors, or ratchets, are devices which "rectify" Brownian motion, i.e. they can generate a current of particles out of unbiased fluctuations. The ratchet effect is a very general phenomenon which applies to a wide range of physical systems, and indeed ratchets have been realized with a variety of solid state devices, with optical trap setups as well as with synthetic molecules and granular gases. The present article reviews recent experimental realizations of ac driven ratchets with cold atoms in driven optical lattices. This is quite an unusual system for a Brownian motor as there is no a real thermal bath, and both the periodic potential for the atoms and the fluctuations are determined by laser fields. Such a system allowed us to realize experimentally rocking and gating ratchets, and to precisely investigate the relationship between symmetry and transport in these ratchets, both for the case of periodic and quasiperiodic driving.

Brownian motors, or ratchets, are devices which "rectify" Brownian motion, i.e. they can generate a current of particles out of unbiased fluctuations. The ratchet effect is a very general phenomenon which applies to a wide range of physical systems, and indeed ratchets have been realized with a variety of solid state devices, with optical trap setups as well as with synthetic molecules and granular gases. The present article reviews recent experimental realizations of ac driven ratchets with cold atoms in driven optical lattices. This is quite an unusual system for a Brownian motor as there is no a real thermal bath, and both the periodic potential for the atoms and the fluctuations are determined by laser fields. Such a system allowed us to realize experimentally rocking and gating ratchets, and to precisely investigate the relationship between symmetry and transport in these ratchets, both for the case of periodic and quasiperiodic driving.

1 Louisiana Tech University Continuing Education & Distance Learning 720 West Railroad Avenue, PO training. ENERGY CONSERVATION - BASIC ELECTRICAL CONCEPTS - 8 Hours - $119 The purpose of this course is to acquaint you with the basic concepts of electricity and how to use those concepts to maximize efficiency

and each point in {1,...,N} represents (the center of) an atom; when lij = uij ... Ea ad Er are appealing for their smoothness that allows to use efficient local min- ... 200-atom fragments, and generated distance data for pairs in successive residues ...... J. P. K. Doye, Global optimization by basin-hopping and the lowest energy.

Our corpus of descriptive text contains a significant number of long-distance pronominal references(8.4% of the total). In order to account for howthese pronouns are interpreted, we re-examine Grosz and Sidner’s theory of ...

Inflation can act as a space-time microscope for Planck or string scale effects, leaving potentially observable traces in the primordial perturbation spectrum. I discuss two frameworks that were used recently to study this phenomenon: nonlinear dispersion and short distance uncertainty.

Inflation can act as a space-time microscope for Planck or string scale effects, leaving potentially observable traces in the primordial perturbation spectrum. I discuss two frameworks that were used recently to study this phenomenon: nonlinear dispersion and short distance uncertainty.

of humans and their companion domestic animals and livestock. Students learn that there are certain "at riskPREPARING THE VIRTUAL CLASSROOM FOR DISTANCE DELIVERY: MEDICAL-VETERINARY ENTOMOLOGY CLINICS laboratory," library materials, conventional lectures and the 43 virtual patients in the clinics

Estimation of Evolutionary Distance between Nucleotide Sequences' Fumio Tajima and Masatoshi Nei University of Texas at Houston A mathematical formula for estimating the average number of nucleotide sub rates of substitution among different nucleotide pairs. Although this formula is obtained for the equal

We examine the hypothesis that inflation is primarily driven by vacuum energy at a scale indicated by gauge coupling unification. Concretely, we consider a class of hybrid inflation models wherein the vacuum energy associated with a grand unified theory condensate provides the dominant energy during inflation, while a second "inflaton" scalar slow-rolls. We show that it is possible to obtain significant tensor-to-scalar ratios while fitting the observed spectral index.

Introduction ® The Fiber-Lite MI-150 is a 150 Watt quartz halogen fiber optic illuminator designed for general microscopy use. When used with specialty fiber optic cables the MI-150 illuminator can also Illuminator from the carton and retain the manual and any additional documents. ! Remove the fiber optic cable

In order to characterize molecular structures we introduce configurational fingerprint vectors which are counterparts of quantities used experimentally to identify structures. The Euclidean distance between the configurational fingerprint vectors satisfies the properties of a metric and can therefore safely be used to measure dissimilarities between configurations in the high dimensional configuration space. In particular we show that these metrics are a perfect and computationally cheap replacement for the root-mean-square distance (RMSD) when one has to decide whether two noise contaminated configurations are identical or not. We introduce a Monte Carlo approach to obtain the global minimum of the RMSD between configurations, which is obtained from a global minimization over all translations, rotations, and permutations of atomic indices.

A full-field imaging, long working distance, incoherent interference microscope suitable for three-dimensional imaging and metrology of MEMS devices and test structures on a standard microelectronics probe station. A long working distance greater than 10 mm allows standard probes or probe cards to be used. This enables nanometer-scale 3-dimensional height profiles of MEMS test structures to be acquired across an entire wafer while being actively probed, and, optionally, through a transparent window. An optically identical pair of sample and reference arm objectives is not required, which reduces the overall system cost, and also the cost and time required to change sample magnifications. Using a LED source, high magnification (e.g., 50.times.) can be obtained having excellent image quality, straight fringes, and high fringe contrast.

In these studies, the microRNA miR-31 was identified as a potent inhibitor of breast cancer metastasis. miR-31 expression levels were inversely associated with the propensity to develop metastatic disease in human breast ...

, and more elaborate organizational patterns. These issues not only make more difficult the question of who is entitled to claim ownership of materials designed for distance education; they also raise questions about the appropriate distribution... are blurred regarding copyrights and legal ownership. The incorporation of the Internet presents further questions of who owns the property, and even could suggest that multiple individuals or entities could claim part- ownership if the right parties so...

Highlights: •NOD2 is a target gene of miR-122. •miR-122 inhibits LPS-induced apoptosis by suppressing NOD2 in HT-29 cells. •miR-122 reduces the expression of pro-inflammatory cytokines (TNF-? and IFN-?). •miR-122 promotes the release of anti-inflammatory cytokines (IL-4 and IL-10). •NF-?B signaling pathway is involved in inflammatory response induced by LPS. -- Abstract: Crohn’s disease (CD) is one of the two major types of inflammatory bowel disease (IBD) thought to be caused by genetic and environmental factors. Recently, miR-122 was found to be deregulated in association with CD progression. However, the underlying molecular mechanisms remain unclear. In the present study, the gene nucleotide-binding oligomerization domain 2 (NOD2/CARD15), which is strongly associated with susceptibility to CD, was identified as a functional target of miR-122. MiR-122 inhibited LPS-induced apoptosis by suppressing NOD2 in HT-29 cells. NOD2 interaction with LPS initiates signal transduction mechanisms resulting in the activation of nuclear factor ?B (NF-?B) and the stimulation of downstream pro-inflammatory events. The activation of NF-?B was inhibited in LPS-stimulated HT-29 cells pretreated with miR-122 precursor or NOD2 shRNA. The expression of the pro-inflammatory cytokines TNF-? and IFN-? was significantly decreased, whereas therelease of the anti-inflammatory cytokines IL-4 and IL-10 was increased in LPS-stimulated HT-29 cells pretreated with miR-122 precursor, NOD2 shRNA or the NF-?B inhibitor QNZ. Taken together, these results indicate that miR-122 and its target gene NOD2 may play an important role in the injury of intestinal epithelial cells induced by LPS.

The distance to NGC 7331 has been derived from Cepheid variables observed with HST/WFPC2, as part of the Extragalactic Distance Scale Key Project. Multi-epoch exposures in F555W (V) and F814W (I), with photometry derived independently from DoPHOT and DAOPHOT/ALLFRAME programs, were used to detect a total of 13 reliable Cepheids, with periods between 11 and 42 days. The relative distance moduli between NGC 7331 and the LMC, imply an extinction to NGC 7331 of A_V = 0.47+-0.15 mag, and an extinction-corrected distance modulus to NGC 7331 of 30.89+-0.14(random) mag, equivalent to a distance of 15.1 Mpc. There are additional systematic uncertainties in the distance modulus of +-0.12 mag due to the calibration of the Cepheid Period-Luminosity relation, and a systematic offset of +0.05+-0.04 mag if we applied the metallicity correction inferred from the M101 results of Kennicutt et al 1998.

Organic liquid scintillation detectors are valuable for the detection of special nuclear material since they are capable of detecting both neutrons and gamma rays. Scintillators can also provide energy information which is helpful in identification and characterization of the source. In order to design scintillation based measurement systems appropriate simulation tools are needed. MCNPX-PoliMi is capable of simulating scintillation detector response; however, simulations have traditionally been run in analog mode which leads to long computation times. In this paper, non-analog MCNPX-PoliMi mode which uses variance reduction techniques is applied and tested. The non-analog MCNPX-PoliMi simulation test cases use source biasing, geometry splitting and a combination of both variance reduction techniques to efficiently simulate pulse height distribution and then time-of-flight for a heavily shielded case with a {sup 252}Cf source. An improvement factor (I), is calculated for distributions in each of the three cases above to analyze the effectiveness of the non-analog MCNPX-PoliMi simulations in reducing computation time. It is found that of the three cases, the last case which uses a combination of source biasing and geometry splitting shows the most improvement in simulation run time for the same desired variance. For pulse height distributions speedup ranging from a factor 5 to 25 is observed, while for time-of-flights the speedup factors range from 3 to 10. (authors)

The NuMI beam at Fermilab has delivered over 5 x 10{sup 20} 120 GeV protons to the neutrino production target since the start for MINOS [1] neutrino oscillation experiment operation in 2005. We report on proton beam commissioning and operation status, including successes and challenges with this beam.

New Loops! MiTeGen* 50µMicroMountsTM consist of a thin microfabricated polyimide film attached to a solid non-magnetic stainless steel pin. The film is polyimide, which is used in Kapton® tape and is employed for X- ray transparent windows on X-ray beam lines. The film is curved by wrapping polyimide film

We investigated the effects of deforestation on mi- croclimates and sporogonic development membrane feeders. Fed mosquitoes were placed in houses in forested and deforest- ed areas in a highland area (1,500 m above sea level) and monitored for parasite development. Deforested sites had higher

MI FARM TO SCHOOL GRANTEES 2014-2015 PROGRAM YEAR AND PREVIOUS GRANTEES FOODSYSTEMS.MSU.EDU 2014-2015 GRANTEES School/ district/ program County Current Grant Years as a grantee A&W Daycare Wayne Planning 1 TO SCHOOL GRANTEES (2011/12 ­ 2013/14) School/ district/ program County Grant Type(s) Grant Years All Aboard

BNL/SNS TECHNICAL NOTE NO. 118 R. Witkover, D. Gassner, C. Mi BNL, Upton, NY 11973, USA October 31, 2002 The SNS BLM System is designed to measure beam losses from a maximum 1% local loss down to a 1 W/m operating loss tolerance. In fact, resolution of 1 % of the 1 W/m threshold has been requested. This amounts

AUSTRALIAN. N~TIONAL UNIVE~SITY DEPARTMENTO:miNUCLEAR PFf-y'SICS 14UD TANK OPENING REPORT/iNo. 51 functions for which it provides power. An order was . immediately placed with N.E.C. for 28 perspex bars microamp hours of b.d.p. generation than its predicted lifetime. In preparation for the next opening

A thermal radiation shield for cooled portable gamma-ray spectrometers. The thermal radiation shield is located intermediate the vacuum enclosure and detector enclosure, is actively driven, and is useful in reducing the heat load to mechanical cooler and additionally extends the lifetime of the mechanical cooler. The thermal shield is electrically-powered and is particularly useful for portable solid-state gamma-ray detectors or spectrometers that dramatically reduces the cooling power requirements. For example, the operating shield at 260K (40K below room temperature) will decrease the thermal radiation load to the detector by 50%, which makes possible portable battery operation for a mechanically cooled Ge spectrometer.

Pellet injection can trigger ballooning like instability in tokamaks, driven by the large pressure perturbation of the pellet cloud. The instability is easier to excite when pellets are injected on the low magnetic field side of the tokamak, which is the usual case. This is because the pellet pressure perturbation tends to add to the background pressure drive. When pellets are injected on the high field side, the instability is harder to excite, because the pellet pressure perturbation opposes the background pressure drive. Nonlinearly, the instability causes fragmentation of the pellet cloud, and can give anomalous pellet penetration. This effect might explain recent experimental observations. (c) 2000 American Institute of Physics.

Protostellar outflows crisscross the regions of star cluster formation, stirring turbulence and altering the evolution of the forming cluster. We model the stirring of turbulent motions by protostellar outflows, building on an observation that the scaling law of supersonic turbulence implies a momentum cascade analogous to the energy cascade in Kolmogorov turbulence. We then generalize this model to account for a diversity of outflow strengths, and for outflow collimation, both of which enhance turbulence. For a single value of its coupling coefficient the model is consistent with turbulence simulations by Li & Nakamura and, plausibly, with observations of the NGC 1333 cluster-forming region. Outflow-driven turbulence is strong enough to stall collapse in cluster-forming regions for several crossing times, relieving the mismatch between star formation and turbulent decay rates. The predicted line-width-size scaling implies radial density indices between -1 and -2 for regions supported by outflow-driven turbulence, with a tendency for steeper profiles in regions that are more massive or have higher column densities.

A plasma decelerating stage is investigated as a compact alternative for the disposal of high-energy beams (beam dumps). This could benefit the design of laser-driven plasma accelerator (LPA) applications that require transportability and or high-repetition-rate operation regimes. Passive and laser-driven (active) plasma-based beam dumps are studied analytically and with particle-in-cell (PIC) simulations in a 1D geometry. Analytical estimates for the beam energy loss are compared to and extended by the PIC simulations, showing that with the proposed schemes a beam can be efficiently decelerated in a centimeter-scale distance.

The distance to NGC 4725 has been derived from Cepheid variables, as part of the Hubble Space Telescope Key Project on the Extragalactic Distance Scale. Thirteen F555W (V) and four F814W (I) epochs of cosmic-ray-split Wide Field and Planetary Camera 2 observations were obtained. Twenty Cepheids were discovered, with periods ranging from 12 to 49 days. Adopting a Large Magellanic Cloud distance modulus and extinction of 18.50+/-0.10 mag and E(V-I)=0.13 mag, respectively, a true reddening-corrected distance modulus (based on an analysis employing the ALLFRAME software package) of 30.50 +/- 0.16 (random) +/- 0.17 (systematic) mag was determined for NGC 4725. The corresponding of distance of 12.6 +/- 1.0 (random) +/- 1.0 (systematic) Mpc is in excellent agreement with that found with an independent analysis based upon the DoPHOT photometry package. With a foreground reddening of only E(V-I)=0.02, the inferred intrinsic reddening of this field in NGC 4725, E(V-I)=0.19, makes it one of the most highly-reddened, encountered by the HST Key Project, to date.

We develop a small distance expansion for the radiative heat transfer between gently curved objects, in terms of the ratio of distance to radius of curvature. A gradient expansion allows us to go beyond the lowest-order ...

Threshold: The thesis explores descriptions of threshold. Threshold is not an ordinary space. It relates to the here and the there and the understanding of distance. It is the phenomena of distance, no matter how close ...

Considerable attention has been paid to ferroic systems in pursuit of advanced applications in past decades. Most recently, the emergence and development of multiferroics, which exhibit the coexistence of different ferroic natures, has offered a new route to create functionalities in the system. In this manuscript, we step from domain engineering to explore a roadmap for discovering intriguing phenomena and multifunctionalities driven by periodic domain patters. As-grown periodic domains, offering exotic order parameters, periodic local perturbations and the capability of tailoring local spin, charge, orbital and lattice degrees of freedom, are introduced as modeling templates for fundamental studies and novel applications. We discuss related significant findings on ferroic domain, nanoscopic domain walls, and conjunct heterostructures based on the well-organized domain patterns, and end with future prospects and challenges in the field.

conditions Dictyostelium cells move by a combination of F-actin-driven protrusions and blebs. Blebbing is characterized by the rapid projection of hemispherical patches of plasma membrane at 2-4 times the speed of an actin-driven projection, and leaves...

.2.11 [Distributed Artificial Intelligence]: Multiagent Systems; I.2.4 [Knowledge representation is that of votewise distances [12], which "lift" distances over individual votes to distances over entire elections and analysis of multiagent systems [13]. However, voting procedures that have been developed for human

Interactions of protons (p) with the NuMI (Neutrinos at the Main Injector) target are used to create the neutrino beam for the MINOS (Main Injector Neutrino Oscillation Search) Experiment. Using the MIPP (Main Injector Particle Production) experimental apparatus, the production of charged pions and kaons in p+NuMI interactions is studied. The data come from a sample of 2 x 10{sup 6} events obtained by MIPP using the 120 GeV/c proton beam from the Main Injector at Fermi National Accelerator Laboratory in Illinois, USA. Pions and kaons are identified by measurement in a Ring Imaging Cherenkov detector. Presented are measurements of {pi}{sup -}/{pi}{sup +}, K{sup -}/K{sup +}, {pi}{sup +}/K{sup +} and {pi}{sup -}/K{sup -} production ratios in the momentum range p{sub T} < 2 GeV/c transversely and 20 GeV/c < p{sub z} < 90 GeV/c longitudinally. Also provided are detailed comparisons of the MIPP NuMI data with the MIPP Thin Carbon data, the MIPP Monte Carlo simulation and the current MINOS models in the relevant momentum ranges.

Highlight: •MiR-21 plays a significant role in 5-FU resistance. •This role might be attributed to targeting of hMSH2 as well as TP and DPD via miR-21 targeted hMSH2. •Indirectly targeted TP and DPD to influence 5-FU chemotherapy sensitivity. -- Abstract: 5-Fluorouracil (5-FU) is a classic chemotherapeutic drug that has been widely used for colorectal cancer treatment, but colorectal cancer cells are often resistant to primary or acquired 5-FU therapy. Several studies have shown that miR-21 is significantly elevated in colorectal cancer. This suggests that this miRNA might play a role in this resistance. In this study, we investigated this possibility and the possible mechanism underlying this role. We showed that forced expression of miR-21 significantly inhibited apoptosis, enhanced cell proliferation, invasion, and colony formation ability, promoted G1/S cell cycle transition and increased the resistance of tumor cells to 5-FU and X radiation in HT-29 colon cancer cells. Furthermore, knockdown of miR-21 reversed these effects on HT-29 cells and increased the sensitivity of HT-29/5-FU to 5-FU chemotherapy. Finally, we showed that miR-21 targeted the human mutS homolog2 (hMSH2), and indirectly regulated the expression of thymidine phosphorylase (TP) and dihydropyrimidine dehydrogenase (DPD). These results demonstrate that miR-21 may play an important role in the 5-FU resistance of colon cancer cells.

We state a condition for an observer to be comoving with another observer in general relativity, based on the concept of lightlike simultaneity. Taking into account this condition, we study relative velocities, Doppler effect and light aberration. We obtain that comoving observers observe the same light ray with the same frequency and direction, and so gravitational redshift effect is a particular case of Doppler effect. We also define a distance between an observer and the events that it observes, that coincides with the known affine distance. We show that affine distance is a particular case of radar distance in the Minkowski space-time and generalizes the proper radial distance in the Schwarzschild space-time. Finally, we show that affine distance gives us a new concept of distance in Robertson-Walker space-times, according to Hubble law.

This thesis presents an efficient and biologically informed 3D human body morphing technique through data-driven alteration of standardized 3D models. The anthropometric data is derived from a large empirical database and processed using principal...

in a micro-channel is studied. External electric field, flow rate of pressure driven flow, and geometry in the micro-channel are manipulated to obtain the focusing point, which led to determination of the electrophoretic mobility and (relative...

Diffusion-driven flow is the result of a conflict between hydrostatic equilibrium in a density stratified fluid and the no-flux boundary condition that must be obeyed on impermeable boundaries that are sloping with respect ...

Highlights: •MiR-145 is downregulated in human ovarian cancer. •MiR-145 targets p70S6K1 and MUC1. •p70S6K1 and MUC1 are involved in miR-145 mediated tumor cell growth and cell invasion, respectively. -- Abstract: MicroRNAs (miRNAs) are a family of small non-coding RNA molecules that regulate gene expression at post-transcriptional levels. Previous studies have shown that miR-145 is downregulated in human ovarian cancer; however, the roles of miR-145 in ovarian cancer growth and invasion have not been fully demonstrated. In the present study, Northern blot and qRT-PCR analysis indicate that miR-145 is downregulated in ovarian cancer tissues and cell lines, as well as in serum samples of ovarian cancer, compared to healthy ovarian tissues, cell lines and serum samples. Functional studies suggest that miR-145 overexpression leads to the inhibition of colony formation, cell proliferation, cell growth viability and invasion, and the induction of cell apoptosis. In accordance with the effect of miR-145 on cell growth, miR-145 suppresses tumor growth in vivo. MiR-145 is found to negatively regulate P70S6K1 and MUC1 protein levels by directly targeting their 3?UTRs. Importantly, the overexpression of p70S6K1 and MUC1 can restore the cell colony formation and invasion abilities that are reduced by miR-145, respectively. MiR-145 expression is increased after 5-aza-CdR treatment, and 5-aza-CdR treatment results in the same phenotype as the effect of miR-145 overexpression. Our study suggests that miR-145 modulates ovarian cancer growth and invasion by suppressing p70S6K1 and MUC1, functioning as a tumor suppressor. Moreover, our data imply that miR-145 has potential as a miRNA-based therapeutic target for ovarian cancer.

In this short note, we examine geodesic distance in Fisher information space in which the metric is defined by the entanglement entropy in CFT_(1+1). It is obvious in this case that the geodesic distance at a constant time is a function of the entropy data embedded into the information space. In a special case, the geodesic equation can be solved analytically, and we find that the distance agrees well with the Ryu-Takayanagi formula. Then, we can understand how the distance looks at the embeded quantum information. The result suggests that the Fisher metric is an efficient tool for constructing the holographic spacetime.

This paper gives an overview of the operation and experience gained in the running of magnetic horns in conventional neutrino beam lines (K2K, MiniBooNE, NuMI and CNGS) over the last decade. Increasing beam power puts higher demands on horn conductors but even more on their hydraulic and electrical systems, while the horn environment itself becomes more hostile due to radiation. Experience shows that designing horns for remote handling and testing them extensively without beam become prerequisites for successful future neutrino beam lines.

The MINOS experiment was designed to measure neutrino oscillation parameters with muon neutrinos. It achieves this by measuring the neutrino energy spectrum and flavor composition of the man-made NuMI neutrino beam 1km after the beam is formed and again after 735 km. By comparing the two spectra it is possible to measure the oscillation parameters. The NuMI beam is made up of 7.0% {bar {nu}}{sub {mu}}, which can be separated from the {nu}{sub {mu}} because the MINOS detectors are magnetized. This makes it possible to study {bar {nu}}{sub {mu}} oscillations separately from those of muon neutrinos, and thereby test CPT invariance in the neutrino sector by determining the {bar {nu}}{sub {mu}} oscillation parameters and comparing them with those for {nu}{sub {mu}}, although any unknown physics of the antineutrino would appear as a difference in oscillation parameters. Such a test has not been performed with beam {bar {nu}}{sub {mu}} before. It is also possible to produce an almost pure {bar {nu}}{sub {mu}} beam by reversing the current through the magnetic focusing horns of the NuMI beamline, thereby focusing negatively, instead of positively charged particles. This thesis describes the analysis of the 7% {bar {nu}}{sub {mu}} component of the forward horn current NuMI beam. The {bar {nu}}{sub {mu}} of a data sample of 3.2 x 10{sup 20} protons on target analysis found 42 events, compared to a CPT conserving prediction of 58.3{sub -7.6}{sup +7.6}(stat.){sub -3.6}{sup +3.6}(syst.) events. This corresponds to a 1.9 {sigma} deficit, and a best fit value of {Delta}{bar m}{sub 32}{sup 2} = 18 x 10{sup -3} eV{sup 2} and sin{sup 2} 2{bar {theta}}{sub 23} = 0.55. This thesis focuses particularly on the selection of {bar {nu}}{sub {mu}} events, and investigates possible improvements of the selection algorithm. From this a different selector was chosen, which corroborated the findings of the original selector. The thesis also investigates how the systematic errors affect the precision of {Delta}{bar m}{sub 32}{sup 2} and sin{sup 2} 2{bar {theta}}{sub 23}. Furthermore, it describes a study to determine the gains of the PMTs via the single-photoelectron spectrum. The results were used as a crosscheck of the gains determined at higher intensities by an LED-based light-injection system.

Pet Video Chat: Monitoring and Interacting with Dogs over Distance Abstract Companies are now making video-communication systems that allow pet owners to see, and, in some cases, even interact with their pets when they are separated by distance. Such `doggie cams' show promise, yet it is not clear how pet

that can be used for this purpose is that of votewise distances [EFS10b], which "lift" distances over, social choice theory emerges as an important tool in the design and analysis of multiagent systems [ER97 for artificial agents and vice versa. For instance, there are voting rules (such as, e.g., single transferable

Risø-R-1518(EN) The necessary distance between large wind farms offshore - study Sten Frandsen. As it is often the need for offshore wind farms, the model handles a regular array-geometry with straight rows distance between large wind farms in the offshore environment. The main results are given in Section 1

migration distances from source rocks to reservoirs can greatly help in the search for new petroleum and correlates solely with migration distance from source rock to reservoir. Case studies serve to demonstrate alteration of buried organic matter in source rocks, followed by oil expulsion (primary migration) out

Abstract: Turbo Codes are a class of powerful error correction codes that were introduced in 1993 by a group of researchers from France, which has the performance near the limit of Claude Shannon. After the introduction of turbo codes it has given raise a tremendous research work related to the new coding theory. This paper addresses the performance of Turbo codes by examining the codes ’ distance spectrum. It is well known that error floor occurs in the performance curve of turbo codes at moderate to high signal-to-noise ratio. The cause of error floor is due to the relatively low free distance of the codewords. Several techniques were proposed by researchers to lower the error floor. These techniques are assessed in this paper. To determine the free distance several algorithms were developed by different researchers. In this paper we used one of the recent algorithm to evaluate the distance spectrum of Turbo codes. We concentrate our analysis to measure and explain the distance spectrum of UMTS (Universal Mobile Telecommunication System), cdma2000 and CCSDS (Consultative Committee for Space Data Systems) standards Turbo Codes. It is shown that the distance spectrum depends on the code rate, interleaver size and the interleaver type.This distance spectrum of turbo codes can be used to estimate its performance at medium to higher SNR (signal to noise ratio). From our analysis we find out that the distance spectrum is one of the elementary issues using which one can find the optimum architecture of Turbo codes for specific application.

Molecular dynamics (MD) simulations have been carried out to investigate the slip of fluid in the lid driven cavity flow where the no-slip boundary condition causes unphysical stress divergence. The MD results not only show the existence of fluid slip but also verify the validity of the Navier slip boundary condition. To better understand the fluid slip in this problem, a continuum hydrodynamic model has been formulated based upon the MD verification of the Navier boundary condition and the Newtonian stress. Our model has no adjustable parameter because all the material parameters (density, viscosity, and slip length) are directly determined from MD simulations. Steady-state velocity fields from continuum calculations are in quantitative agreement with those from MD simulations, from the molecular-scale structure to the global flow. The main discovery is as follows. In the immediate vicinity of the corners where moving and fixed solid surfaces intersect, there is a core partial-slip region where the slippage is large at the moving solid surface and decays away from the intersection quickly. In particular, the structure of this core region is nearly independent of the system size. On the other hand, for sufficiently large system, an additional partial-slip region appears where the slippage varies as $1/r$ with $r$ denoting the distance from the corner along the moving solid surface. The existence of this wide power-law region is in accordance with the asymptotic $1/r$ variation of stress and the Navier boundary condition.

We develop a general theory of microtubule (MT) deformations by molecular motors generating internal force doublets within the MT lattice. We describe two basic internal excitations, the S and V shape, and compare them with experimental observations from literature. We explain the special role of tubulin vacancies and the dramatic deformation amplifying effect observed for katanin acting at positions of defects. Experimentally observed shapes are used to determine the ratio of MT shear and stretch moduli ($\\approx 6\\times10^{-5}$) and to estimate the forces induced in the MT lattice by katanin (10's of pN). For many motors acting on a single MT we derive expressions for the end-to-end distance reduction and provide criteria for dominance of this new effect over thermal fluctuations. We conclude that molecular motors if acting cooperatively can ''animate'' MTs from within the lattice and induce slack even without cross-bridging to other structures, a scenario very much reminiscent of the motor driven axoneme.

The Minos+ experiment is an extension of the Minos experiment at a higher energy and more intense neutrino beam, with the data collection having begun in the fall of 2013. The neutrino beam is provided by the Neutrinos from the Main Injector (NuMI) beam-line at Fermi National Accelerator Laboratory (Fermilab). The detector apparatus consists of two main detectors, one underground at Fermilab and the other in Soudan, Minnesota with the purpose of studying neutrino oscillations at a base line of 735 km. The original data acquisition system has been running for several years collecting data from NuMI, but with the extended run from 2013, parts of the system needed to be replaced due to obsolescence, reliability problems, and data throughput limitations. Specifically, we have replaced the front-end readout controllers, event builder, and data acquisition computing and trigger processing farms with modern, modular and reliable devices with few single points of failure. The new system is based on gigabit Ethernet T...

facility 4 mi offshore. The nearest refinery is 9 mi east of the shore point nearest the docking facility. A pipeline must be constructed connecting the docking facility with the refinery. The pipeline costs $300.42 miles away from the refinery, or equivalently 3.58 miles away from Point A (as the back of the book has

Sawtooth driven particle transport in tokamak plasmas ThÃ¨se de doctorat soutenue publiquement le 09-00926428,version1-9Jan2014 #12;Abstract The radial transport of particles in tokamaks is one of the most-sweeping reectometry on the JET and Tore Supra tokamaks. The presence of these structure may indicate a low eciency

A microwave-driven ultraviolet (UV) light source is provided. The light source comprises an over-moded microwave cavity having at least one discharge bulb disposed within the microwave cavity. At least one magnetron probe is coupled directly to the microwave cavity.

MLL-AF4 Acute Lymphocytic Leukemia has a poor prognosis, and the mechanisms by which these leukemias develop are not understood despite intensive research based on well-known concepts and methods. MicroRNAs (miRNAs) are a ...

We explore the minimum distance from a host star where an exoplanet could potentially be habitable in order not to discard close-in rocky exoplanets for follow-up observations. We find that the inner edge of the Habitable ...

Calibration of Distance and Size Does Not Calibrate Shape Information: Comparison of Dynamic to monocular vision. That is, when participants were not allowed to calibrate their reaches, performance using

The most popular class of quantum error correcting codes is stabilizer codes. Binary quantum stabilizer codes have been well studied, and Calderbank, Rains, Shor and Sloane (July 1998) have constructed a table of upper bounds on the minimum distance...

We have developed a media player for use in distance education. The player can incorporate several time-indexed sources, including video, audio, PowerPoint, and text index. We have converted all the SMA 5503 Introduction ...

of the parameters. For K > 1, the k-means algo- rithm and optionally the expectation-maximization algo- rithm Gaussian mixture models is frequently needed. We present a comparison of the Kullback-Leibler distance

Type IIP supernovae (SNe) are recognized as independent extragalactic distance indicators; however, keeping in mind the diverse nature of their observed properties as well as the availability of good quality data, more and newer events need to be tested for their applicability as reliable distance indicators. We use early photometric and spectroscopic data of eight Type IIP SNe to derive distances to their host galaxies by using the expanding photosphere method (EPM). For five of these, the EPM is applied for the first time. In this work, we improved EPM application by using SYNOW estimated velocities and by semi-deconvolving the broadband filter responses while deriving color temperatures and blackbody angular radii. We find that the derived EPM distances are consistent with that derived using other redshift-independent methods.

While many studies have looked at the effect of various factors on cognitive distance, interactional effects of two or more factors have not been examined. The objective of this study was to investigate the effects of information exposure...

While many studies have looked at the effect of various factors on cognitive distance, interactional effects of two or more factors have not been examined. The objective of this study was to investigate the effects of information exposure...

In a laser ion source, plasma drift distance is one of the most important design parameters. Ion current density and beam pulse width are defined by plasma drift distance between laser target and beam extraction position. In direct plasma injection scheme (DPIS), which uses a laser ion source and Radio Frequency Quadrupole (RFQ) linac, we can apply relatively higher electric field at the beam extraction due to the unique shape of a positively biased electrode. However, when we aim at very high current acceleration like several tens of mA, we observed mismatched beam extraction conditions. We tested three different ion current at ion extraction region by changing plasma drift distance to study better extraction condition. In this experiment, C{sup 6+} beam was accelerated. We confirmed that the matching condition can be improved by controlling plasma drift distance.

The Neutrinos at the Main Injector (NuMI) beamline will deliver an intense muon neutrino beam by focusing a beam of mesons into a long evacuated decay volume. The beam must be steered with 1 mRad angular accuracy toward the Soudan Underground Laboratory in northern Minnesota. We have built 4 arrays of ionization chambers to monitor the neutrino beam direction and quality. The arrays are located at 4 stations downstream of the decay volume, and measure the remnant hadron beam and tertiary muons produced along with neutrinos in meson decays. We review how the monitors will be used to make beam quality measurements, and as well we review chamber construction details, radiation damage testing, calibration, and test beam results.

The NuMI Facility was intended to be flexibly changed between 3 energies of beams, LE, ME, and HE. However, the changeover requires extensive downtime to move and realign horns and the target. We propose to implement a flexible arrangement where the target can be remotely moved in the beamline direction to change the beam energy and the horns remain fixed. In addition to having the attractive feature of keeping the horn optics fixed, the motion of the target can be performed more quickly and hence on a more frequent basis. We discuss potential increases in statistics in the high energy region, systematic cross-checks available, and the improved beam monitoring capabilities with such variable energy beams.

) size range, the first and most important step is the isolation of high-quality total RNA. Because RNA will present a set of total RNA isolation methods that can be used to maximize the recovery of high-quality RNAChapter 3 Methods for Isolation of Total RNA to Recover miRNAs and Other Small RNAs from Diverse

Corrosion mechanisms of low level vitrified radioactive waste in a loamy soil M.I. Ojovan1 , W to 19 o C. Both ion-exchange and hydrolysis control the corrosion of this glass. Processing of field disposal facilities, which presumes an understanding of the main glass corrosion mechanisms. The corrosion

The Main Injector Neutrino Oscillation Search (MINOS) is a two detector long-baseline neutrino experiment designed to study the disappearance of muon neutrinos. MINOS will test the {nu}{sub {mu}} {yields} {nu}{sub {tau}} oscillation hypothesis and measure precisely {Delta}m{sub 23}{sup 2} and sin{sup 2} 2{theta}{sub 23} oscillation parameters. The source of neutrinos for MINOS experiment is Fermilab's Neutrinos at the Main Injector (NuMI) beamline. The energy spectrum and the composition of the beam is measured at two locations, one close to the source and the other 735 km down-stream in the Soudan Mine Underground Laboratory in northern Minnesota. The precision measurement of the oscillation parameters requires an accurate prediction of the neutrino flux at the Far Detector. This thesis discusses the calculation of the neutrino flux at the Far Detector and its uncertainties. A technique that uses the Near Detector data to constrain the uncertainties in the calculation of the flux is described. The data corresponding to an exposure of 2.5 x 10{sup 20} protons on the NuMI target is presented and an energy dependent disappearance pattern predicted by neutrino oscillation hypotheses is observed in the Far Detector data. The fit to MINOS data, for given exposure, yields the best fit values for {Delta}m{sub 23}{sup 2} and sin{sup 2} 2{theta}{sub 23} to be (2.38{sub -0.16}{sup +0.20}) x 10{sup -3} eV{sup 2}/c{sup 4} and 1.00{sub -0.08}, respectively.

Many safeguards measurement systems used at nuclear facilities, both domestically and internationally, rely on He-3 detectors and well established mathematical equations to interpret coincidence and multiplicity-type measurements for verifying quantities of special nuclear material. Due to resource shortages alternatives to these existing He-3 based systems are being sought. Work is also underway to broaden the capabilities of these types of measurement systems in order to improve current multiplicity analysis techniques. As a part of a Material Protection, Accounting, and Control Technology (MPACT) project within the U.S. Department of Energy's Fuel Cycle Technology Program we are designing a fast-neutron multiplicity counter with organic liquid scintillators to quantify important quantities such as plutonium mass. We are also examining the potential benefits of using fast-neutron detectors for multiplicity analysis of advanced fuels in comparison with He-3 detectors and testing the performance of such designs. The designs are being developed and optimized using the MCNPX-PoliMi transport code to study detector response. In the full paper, we will discuss validation measurements used to justify the use of the MCNPX-PoliMi code paired with the MPPost multiplicity routine to design a fast neutron multiplicity counter with liquid scintillators. This multiplicity counter will be designed with the end goal of safeguarding advanced nuclear fuels. With improved timing qualities associated with liquid scintillation detectors, we can design a system that is less limited by nuclear materials of high activities. Initial testing of the designed system with nuclear fuels will take place at Idaho National Laboratory in a later stage of this collaboration.

DRIVEN PIPE PILES IN DENSE SAND BYRON BYRNE GEOMECHANICS GROUP THE UNIVERSITY OF WESTERN AUSTRALIA #12;Driven Pipe Piles in Dense Sand Byron Byrne Geomechanics Group The University of Western Australia #12;Driven Pipe Piles in Dense Sand Byron Byrne Geomechanics Group The University of Western Australia

This grant has supported a study of some fundamental problems in current- and flow-driven instabilities in plasmas and their applications in inertial confinement fusion (ICF) and astrophysics. It addressed current-driven instabilities and their roles in fast ignition, and flow-driven instabilities and their applications in astrophysics.

Business Process driven solutions for innovative enterprise information systems F. Taglino, M. In particular, it will be argued about business process driven approach to information systems development and overcome current limits. Business process driven approach to IS development is here characterized by: (i

Model-Driven Business Process Recovery Ying Zou1 , Terence C. Lau2 , Kostas Kontogiannis3 , Tack. In this paper, we propose a model-driven business process recovery framework that captures the essential-to-date linkage between business tasks and their implementation in source code, we propose a model-driven business

This article presents the concept of an all-dielectric laser-driven undulator for the generation of coherent X-rays. The proposed laser-driven undulator is expected to produce internal deflection forces equivalent to a several-Tesla magnetic field acting on a speed-of-light particle. The key idea for this laser-driven undulator is its ability to provide phase synchronicity between the deflection force and the electron beam for a distance that is much greater than the laser wavelength. The potential advantage of this undulator is illustrated with a possible design example that assumes a small laser accelerator which delivers a 2 GeV, 1 pC, 1 kHz electron bunch train to a 10 cm long, 1/2 mm period laser-driven undulator. Such an undulator could produce coherent X-ray pulses with {approx}10{sup 9} photons of 64 keV energy. The numerical modeling for the expected X-ray pulse shape was performed with GENESIS, which predicts X-ray pulse durations in the few-attosecond range. Possible applications for nonlinear electromagnetic effects from these X-ray pulses are briefly discussed.

We investigate the properties of magnetic islands arising from tearing instabilities that are driven by an interchange turbulence. We find that such islands possess a specific signature that permits an identification of their origin. We demonstrate that the persistence of a small scale turbulence maintains a mean pressure profile, whose characteristics makes it possible to discriminate between turbulence driven islands from those arising due to an unfavourable plasma current density gradient. We also find that the island poloidal turnover time, in the steady state, is independent of the levels of the interchange and tearing energy sources. Finally, we show that a mixing length approach is adequate to make theoretical predictions concerning island flattening in the island rotation frame.

Proton beam transport in the context of proton driven Fast Ignition is usually assumed to be stable due to protons high inertia, but an analytical analysis of the process is still lacking. The stability of a charge and current neutralized proton beam passing through a plasma is therefore conducted here, for typical proton driven Fast Ignition parameters. In the cold regime, two fast growing Buneman-like modes are found, with an inverse growth-rate much smaller than the beam time-of-flight to the target core. The stability issue is thus not so obvious, and Kinetic effects are investigated. One unstable mode is found stabilized by the background plasma protons and electrons temperatures. The second mode is also damped, providing the proton beam thermal spread is larger than $\\sim$ 10 keV. In Fusion conditions, the beam propagation should therefore be stable.

We discuss simulated photonic crystal structure designs for laser-driven particle acceleration, focusing on three-dimensional planar structures based on the so-called ''woodpile'' lattice. We demonstrate guiding of a speed-of-light accelerating mode by a defect in the photonic crystal lattice and discuss the properties of this mode. We also discuss particle beam dynamics in the structure, presenting a novel method for focusing the beam. In addition we describe some potential coupling methods for the structure.

We study the compression driven magnetic reconnection in the relativistic electron-positron plasma. Making use of a 2.5D particle-in-cell code, we simulated compression of a magnetized plasma layer containing a current sheet within it. We found that the particle spectrum within the reconnecting sheet becomes non-thermal; it could be approximated by a power-law distribution with an index of -1 and an exponential cutoff.

The purpose of this research project was to develop an improved understanding of how electriexecy driven processes, including electrocoalescence, acoustic agglomeration, and electric filtration, may be employed to efficiently treat problems caused by the formation of aerosols during DOE waste treatment operations. The production of aerosols during treatment and retrieval operations in radioactive waste tanks and during thermal treatment operations such as calcination presents a significant problem of cost, worker exposure, potential for release, and increased waste volume.

Duffing resonators are typical dynamic systems, which can exhibit chaotic oscillations, subject to certain driving conditions. Chaotic oscillations of resonating systems with negative and positive spring constants are identified to investigate in this paper. Parametric driver imposed on these two systems affects nonlinear behaviours, which has been theoretically analyzed with regard to variation of driving parameters (frequency, amplitude). Systematic calculations have been performed for these two systems driven by parametric pumps to unveil the controllability of chaos.

A method for driving rotation and a countercurrent flow in a fully ionized plasma centrifuge is described. The rotation is produced by radiofrequency waves near the cyclotron resonance. The wave energy is transferred into potential energy in a manner similar to the ? channeling effect. The countercurrent flow may also be driven by radiofrequency waves. By driving both the rotation and the flow pattern using waves instead of electrodes, physical and engineering issues may be avoided.

We report on the design and development of an all-dielectric laser-driven accelerator to be used in the GALAXIE (GV-per-meter Acce Lerator And X-ray-source Integrated Experiment) project's compact free-electron laser. The approach of our working design is to construct eigenmodes, borrowing from the field of photonics, which yield the appropriate, highly demanding dynamics in a high-field, short wavelength accelerator. Topics discussed include transverse focusing, power coupling, bunching, and fabrication.

The requirements for network predictability are becoming increasingly critical to the DoE science community where resources are widely distributed and collaborations are world-wide. To accommodate these emerging requirements, the Energy Sciences Network has established a Science Data Network to provide user driven guaranteed bandwidth allocations. In this paper we outline the design, implementation, and secure coordinated use of such a network, as well as some lessons learned.

We invent an ac-driven quantum motor consisting of two different, interacting ultracold atoms placed into a ring-shaped optical lattice and submerged in a pulsating magnetic field. While the first atom carries a current, the second one serves as a quantum starter. For fixed zero-momentum initial conditions the asymptotic carrier velocity converges to a unique non-zero value. We also demonstrate that this quantum motor performs work against a constant load.

The ionization distances R{sub c}{sup I} as well as the ionization rates and eigenenergies of one-electron multiply charged Rydberg ions (core charge Z>>1, principal quantum number n>>1) approaching solid surfaces are calculated. Within the framework of a nonperturbative etalon equation method (EEM), these quantities are obtained simultaneously. The complex energy eigenvalue problem for the decaying eigenstates is solved within the critical region R{approx_equal}R{sub c}{approx_equal}R{sub c}{sup I} of the ion-surface distances R. This region is characterized by the energy terms localized in the vicinity of the top of an effective potential barrier, created between the ion and polarized solid. We take into account that the parabolic symmetry is preserved for R{approx_equal}R{sub c} and that the parabolic quantum numbers can be taken as approximate but sufficiently good quantum numbers. The parabolic rates, energies, and corresponding ionization distances are presented in relatively simple analytical forms. The ionization distances are compared with the results of a classical overbarrier model. Comparison of the obtained energies and rates with the available theoretical predictions of the coupled angular mode method shows good agreement. The use of the EEM for an estimation of the upper limit of the first neutralization distance in the subsequent neutralization cascade is briefly discussed.

We present time-resolved measurements of the displacement of magnetic domain-walls (DWs) driven by vertical spin-polarized currents in track-shaped magnetic tunnel junctions. In these structures, we observe very high DW velocities (600?m/s) at current densities below 10{sup 7}?A/cm{sup 2}. We show that the efficient spin-transfer torque combined with a short propagation distance allows avoiding the Walker breakdown process and achieving deterministic, reversible, and fast (?1?ns) DW-mediated switching of magnetic tunnel junction elements, which is of great interest for the implementation of fast DW-based spintronic devices.

We present Gemini optical imaging and spectroscopy of the radio source J 133658.3-295105. This source has been suggested to be the core of an FR II radio source with two detected lobes. J 133658.3-295105 and its lobes are aligned with the optical nucleus of M 83 and with three other radio sources at the M 83 bulge outer region. These radio sources are neither supernova remnants nor H II regions. This curious configuration prompted us to try to determine the distance to J 133658.3-295105. We detected H_alpha emission redshifted by ~ 130 km s^-1 with respect to an M 83 H II region 2.5" east-southeast of the radio source. We do not detect other redshifted emission lines of an optical counterpart down to m_i = 22.2 +/- 0.8. Two different scenarios are proposed: the radio source is at z >= 2.5, a much larger distance than the previously proposed lower limit z >= 1.0, or the object was ejected by a gravitational recoil event from the M 83 nucleus. This nucleus is undergoing a strong dynamical evolution, judging from previous three-dimensional spectroscopy.

We show that the usual relation between redshift and angular-diameter distance can be obtained by considering light from a source to be gravitationally lensed by material that lies in the telescope beam as it passes from source to observer through an otherwise empty universe. This derivation yields an equation for the dependence of angular diameter on redshift in an inhomogeneous universe. We use this equation to model the distribution of angular-diameter distance for redshift z=3 in a realistically clustered cosmology. The distribution is such that attempts to determine q_0 from angular-diameter distances will systematically underestimate q_0 by ~0.15, and large samples would be required to beat down the intrinsic dispersion in measured values of q_0.

A table is presented that summarizes published absorption line measurements for the high- and intermediate velocity clouds (HVCs and IVCs). New values are derived for N(HI) in the direction of observed probes, in order to arrive at reliable abundances and abundance limits (the HI data are described in Paper II). Distances to stellar probes are revisited and calculated consistently, in order to derive distance brackets or limits for many of the clouds, taking care to properly interpret non-detections. The main conclusions are the following. 1) Absolute abundances have been measured using lines of SII, NI and OI, with the following resulting values: ~0.1 solar for one HVC (complex C), ~0.3 solar for the Magellanic Stream, ~0.5 solar for a southern IVC, and ~ solar for two northern IVCs (the IV Arch and LLIV Arch). Finally, approximate values in the range 0.5-2 solar are found for three more IVCs. 2) Depletion patterns in IVCs are like those in warm disk or halo gas. 3) Most distance limits are based on strong UV lines of CII, SiII and MgII, a few on CaII. Distance limits for major HVCs are >5 kpc, while distance brackets for several IVCs are in the range 0.5-2 kpc. 4) Mass limits for major IVCs are 0.5-8x10^5 M_sun, but for major HVCs they are >10^6 M_sun. 5) The CaII/HI ratio varies by up to a factor 2-5 within a single cloud, somewhat more between clouds. 6) The NaIHI ratio varies by a factor >10 within a cloud, and even more between clouds. Thus, CaII can be useful for determining both lower and upper distance limits, but NaI only yields upper limits.

We present a theory of quantum stabilizer turbo-encoders with unbounded minimum distance. This theory is presented under a framework common to both classical and quantum turbo-encoding theory. The main conditions to have an unbounded minimum distance are that the inner seed encoder has to be recursive, and either systematic or with a totally recursive truncated decoder. This last condition has been introduced in order to obtain a theory viable in the quantum stabilizer case, since it was known that in this case the inner seed encoder could not be recursive and systematic in the same time.

We present a theory of quantum stabilizer turbo-encoders with unbounded minimum distance. This theory is presented under a framework common to both classical and quantum turbo-encoding theory. The main conditions to have an unbounded minimum distance are that the inner seed encoder has to be recursive, and either systematic or with a totally recursive truncated decoder. This last condition has been introduced in order to obtain a theory viable in the quantum stabilizer case, since it was known that in this case the inner seed encoder could not be recursive and systematic in the same time.

Recently there has been significant interest in evaluating the potential of many different non-ideal energetic materials to cause blast damage. We present a method intended to quantitatively compare the blast loading generated by different energetic materials through use of an explosively driven shock tube. The test explosive is placed at the closed breech end of the tube and initiated with a booster charge. The resulting shock waves are then contained and focused by the tube walls to form a quasi-one-dimensional blast wave. Pressure transducers along the tube wall measure the blast overpressure versus distance from the source and allow the use of the one-dimensional blast scaling relationship to determine the energy deposited into the blast wave per unit mass of test explosive. These values are then compared for different explosives of interest and to other methods of equivalency determination.

Monte Carlo particle transport codes used to accurately model detector response are traditionally run in fully analog mode. Analog simulations of cross-correlation measurements with these codes are extremely time-consuming because the probability of correlated detection is extremely small, approximately equal to the product of the probabilities of a single detection in each detector. The new 'implicit correlation' method described here increases the number of correlation event scores thereby reducing variance and required computation times. The cost of the implicit correlation method is comparable to the cost of simulating single event detection for the lowest absolute detector efficiency in the problem. This method is especially useful in the nuclear non-proliferation and safeguards fields for simulating correlation measurements of shielded special nuclear material. The new method was implemented in MCNPX-PoliMi for neutron-neutron cross-correlations with a Cf-252 spontaneous fission source measured by two detectors of variable stand-offs. The method demonstrated good agreement with analog simulation results for multiple measurement geometries. Small differences between non-analog and analog cross-correlation distributions are attributed to known features of the specific problem simulated that will not be present in practical applications. (authors)

The fixed-target MIPP experiment, Fermilab E907, was designed to measure the production of hadrons from the collisions of hadrons of momenta ranging from 5 to 120 GeV/c on a variety of nuclei. These data will generally improve the simulation of particle detectors and predictions of particle beam fluxes at accelerators. The spectrometer momentum resolution is between 3 and 4%, and particle identification is performed for particles ranging between 0.3 and 80 GeV/c using $dE/dx$, time-of-flight and Cherenkov radiation measurements. MIPP collected $1.42 \\times10^6$ events of 120 GeV Main Injector protons striking a target used in the NuMI facility at Fermilab. The data have been analyzed and we present here charged pion yields per proton-on-target determined in bins of longitudinal and transverse momentum between 0.5 and 80 GeV/c, with combined statistical and systematic relative uncertainties between 5 and 10%.

This report provides technical documentation for values in the Table of Initial Isolation and Protective Action Distances (PADs) in the 2004 Emergency Response Guidebook (ERG2004). The objective for choosing the PADs specified in the ERG2004 is to balance the need to adequately protect the public from exposure to potentially harmful substances against the risks and expenses that could result from overreacting to a spill. To quantify this balance, a statistical approach is adopted, whereby the best available information is used to conduct an accident scenario analysis and develop a set of up to 1,000,000 hypothetical incidents. The set accounts for differences in containers types, incident types, accident severity (i.e., amounts released), locations, times of day, times of year, and meteorological conditions. Each scenario is analyzed using detailed emission rate and atmospheric dispersion models to calculate the downwind chemical concentrations from which a 'safe distance' is determined. The safe distance is defined as the distance downwind from the source at which the chemical concentration falls below health protection criteria. The American Industrial Hygiene Association's Emergency Response Planning Guideline Level 2 (ERPG-2) or equivalent is the health criteria used. The statistical sample of safe distance values for all incidents considered in the analysis are separated into four categories: small spill/daytime release, small spill/nighttime release, large spill/daytime release, and large spill/nighttime release. The 90th-percentile safe distance values for each of these groups became the PADs that appear in the ERG2004.

MicroRNAs regulate networks of genes to orchestrate cellular functions. MiR-125b, the vertebrate homologue of the Caenorhabditis elegans microRNA lin-4, has been implicated in the regulation of neural and hematopoietic ...

A laser driven flyer plate where the flyer plate is deposited directly onto the squared end of an optical fiber. The plasma generated by a laser pulse drives the flyer plate toward a target. In another embodiment, a first metal layer is deposited onto the squared end of an optical fiber, followed by a layer of a dielectric material and a second metal layer. The laser pulse generates a plasma in the first metal layer, but the plasma is kept away from the second metal layer by the dielectric layer until the pressure reaches the point where shearing occurs.

A borehole seismic tool is described including a borehole clamp which only moves perpendicular to the borehole. The clamp is driven by an electric motor, via a right angle drive. When used as a seismic receiver, the tool has a three part housing, two of which are hermetically sealed. Accelerometers or geophones are mounted in one hermetically sealed part, the electric motor in the other hermetically sealed part, and the clamp and right angle drive in the third part. Preferably the tool includes cable connectors at both ends. Optionally a shear plate can be added to the clamp to extend the range of the tool.

An energy beam driven rapid fabrication system, in which an energy beam strikes a growth surface to form a molten puddle thereon. Feed powder is then injected into the molten puddle from a converging flow of feed powder. A portion of the feed powder becomes incorporated into the molten puddle, forcing some of the puddle contents to freeze on the growth surface, thereby adding an additional layer of material. By scanning the energy beam and the converging flow of feed powder across the growth surface, complex three-dimensional shapes can be formed, ready or nearly ready for use. Nearly any class of material can be fabricated using this system.

We present a theoretical study showing that an optically driven excitonic two-level system in a solid state environment acts as a heat pump by means of repeated phonon emission or absorption events. We derive a master equation for the combined phonon bath and two-level system dynamics and analyze the direction and rate of energy transfer as a function of the externally accessible driving parameters. We discover that if the driving laser is detuned from the exciton transition, cooling the phonon environment becomes possible.

We present a theoretical study showing that an optically driven excitonic two-level system in a solid state environment acts as a heat pump by means of repeated phonon emission or absorption events. We derive a master equation for the combined phonon bath and two-level system dynamics and analyze the direction and rate of energy transfer as a function of the externally accessible driving parameters. We discover that if the driving laser is detuned from the exciton transition, cooling the phonon environment becomes possible.

Barrier synchronizations can be very expensive on multiprogramming environment because no process can go past a barrier until all the processes have arrived. If a process participating at a barrier is swapped out by the operating system, the rest of participating processes end up waiting for the swapped-out process. This paper presents a compile-time/run-time system that uses a dependence-driven execution to overlap the execution of computations separated by barriers so that the processes do not spend most of the time idling at the synchronization point.

A borehole seismic tool including a borehole clamp which only moves perpendicular to the borehole. The clamp is driven by an electric motor, via a right angle drive. When used as a seismic receiver, the tool has a three part housing, two of which are hermetically sealed. Accelerometers or geophones are mounted in one hermetically sealed part, the electric meter in the other hermetically sealed part, and the clamp and right angle drive in the third part. Preferably the tool includes cable connectors at both ends. Optionally a shear plate can be added to the clamp to extend the range of the tool.

Secure Hamming Distance Based Computation and Its Applications Ayman Jarrous and Benny Pinkas University of Haifa Abstract. This paper examines secure two-party computation of func- tions which depend for computing these functions. In particular, we present protocols which are secure in the sense of full

. Kobayashi [9]. Instead of S3 he begins with the double of a handlebody V . Instead of a Dehn twist he(S) of projective measured laminations reveals that the set of distances, obtained by altering the original gluing in S which bound disks in V . Let (h) denote the average displacement of h. The following are equivalent. K

with distances of the associated target space. The formalism of multivariate subspace regression (MSR) is based space, such as linear discriminant analysis (LDA) for dis- crete class labels [3], generalized linear.strickert@uni-siegen.de Abstract. A new supervised adaptive metric approach is introduced for mapping an input vector space

Technology Enhanced Learning and Distance Learning February 21, 2008 Call for Nominations: Provost's Prize for Teaching with Technology Eligibility: Candidates must be a tenure-track or non's Prize for Teaching with Technology will be awarded to up to two recipients. Each recipient will receive

sufficiently well in clustering the patient population using k-means clustering algorithm. I. INTRODUCTIONComparison of Distance Metrics for Hierarchical Data in Medical Databases Diman Hassan, Uwe of these metrics have been compared to other measures to find their efficiency. In [5], a comparison has been made

determination and molecular modeling. An energy function, or database potential, is derived from distributionsProtein structure determination using a database of interatomic distance probabilities MICHAEL E for Advanced Science and Technology and National Center for Supercomputing Applications, University of Illinois

of the measurements, and so the difference imaging technique was a success. Additionally, I validated the first “white-light” variability search with the HST F350LP filter for discovering Cepheids. NGC 4921 is located in the heart of the Coma cluster at a distance...

The nonlinear ionization with accompanied photorecombination on closely located center has been considered. The radiation spectrum has been calculated in the frame of the Lewenstein-Corkum approach. The dependence of radiation on the distance between ionization point and the recombination center, and the frequency and laser field strength has been investigated.

Of mice and men: Algorithms for evolutionary distances between genomes with translocation \\Lambda is combinatorial algorithms for genome rearÂ­ rangement. In the course of its evolution, the genome of an organism is to determine the minimum number of such events that transform one genome to another. This number is called

1. Long-distance seed dispersal is difficult to measure, yet key to understanding plant population dynamics and community composition. 2. We used a spatially explicit model to predict the distribution of seeds dispersed long distances by birds into habitat patches of different shapes. All patches were the same type of habitat and size, but varied in shape. They occurred in eight experimental landscapes, each with five patches of four different shapes, 150 m apart in a matrix of mature forest. The model was parameterized with smallscale movement data collected from field observations of birds. In a previous study we validated the model by testing its predictions against observed patterns of seed dispersal in real landscapes with the same types and spatial configuration of patches as in the model. 3. Here we apply the model more broadly, examining how patch shape influences the probability of seed deposition by birds into patches, how dispersal kernels (distributions of dispersal distances) vary with patch shape and starting location, and how movement of seeds between patches is affected by patch shape. 4. The model predicts that patches with corridors or other narrow extensions receive higher numbers of seeds than patches without corridors or extensions. This pattern is explained by edgefollowing behaviour of birds. Dispersal distances are generally shorter in heterogeneous landscapes (containing patchy habitat) than in homogeneous landscapes, suggesting that patches divert the movement of seed dispersers, ‘holding’ them long enough to increase the probability of seed defecation in the patches. Dispersal kernels for seeds in homogeneous landscapes were smooth, whereas those in heterogenous landscapes were irregular. In both cases, long-distance (> 150 m) dispersal was surprisingly common, usually comprising approximately 50% of all dispersal events. 5. Synthesis . Landscape heterogeneity has a large influence on patterns of long-distance seed dispersal. Our results suggest that long-distance dispersal events can be predicted using spatially explicit modelling to scale-up local movements, placing them in a landscape context. Similar techniques are commonly used by landscape ecologists to model other types of movement; they offer much promise to the study of seed dispersal.

Using the Very Long Base Array, we observed the young stellar object EC 95 in the Serpens cloud core at eight epochs from 2007 December to 2009 December. Two sources are detected in our field and are shown to form a tight binary system. The primary (EC 95a) is a 4-5 M {sub sun} proto-Herbig AeBe object (arguably the youngest such object known), whereas the secondary (EC 95b) is most likely a low-mass T Tauri star. Interestingly, both sources are non-thermal emitters. While T Tauri stars are expected to power a corona because they are convective while they go down the Hayashi track, intermediate-mass stars approach the main sequence on radiative tracks. Thus, they are not expected to have strong superficial magnetic fields, and should not be magnetically active. We review several mechanisms that could produce the non-thermal emission of EC 95a and argue that the observed properties of EC 95a might be most readily interpreted if it possessed a corona powered by a rotation-driven convective layer. Using our observations, we show that the trigonometric parallax of EC 95 is {pi} = 2.41 {+-} 0.02 mas, corresponding to a distance of 414.9{sup +4.4} {sub -4.3} pc. We argue that this implies a distance to the Serpens core of 415 {+-} 5 pc and a mean distance to the Serpens cloud of 415 {+-} 25 pc. This value is significantly larger than previous estimates (d {approx} 260 pc) based on measurements of the extinction suffered by stars in the direction of Serpens. A possible explanation for this discrepancy is that these previous observations picked out foreground dust clouds associated with the Aquila Rift system rather than Serpens itself.

Synchronization is a universal phenomenon found in many non-equilibrium systems. Much recent interest in this area has overlapped with the study of complex networks, where a major focus is determining how a system's connectivity patterns affect the types of behavior that it can produce. Thus far, modeling efforts have focused on the tendency of networks of oscillators to mutually synchronize themselves, with less emphasis on the effects of external driving. In this work we discuss the interplay between mutual and driven synchronization in networks of phase oscillators of the Kuramoto type, and resolve how the structure and emergence of such states depends on the underlying network topology for simple random networks with a given degree distribution. We provide a partial bifurcation analysis, centering on the appearance of a Takens-Bogdanov-Cusp singularity, which broadly separates homogeneous and heterogeneous network behavior in a weak coupling limit, and from which the number, stability and appearance of driven and mutually synchronized states can be determined, as a function of a few parameters. We find transitions such as Saddle-Node-Infinite-Periods, Limit-Point-of-Cycles, and Hopf bifurcations (both branches), as well as multiple bistability regions and dynamics that differ for the network types. This description is connected to the underlying dynamics of oscillator clusters for important states and transitions. Our results can provide a basis for studying the problem of frequency controlling disordered oscillator networks.

We investigate the power spectra of outflow-driven turbulence through high-resolution three-dimensional isothermal numerical simulations where the turbulence is driven locally in real-space by a simple spherical outflow model. The resulting turbulent flow saturates at an average Mach number of ~2.5 and is analysed through density and velocity power spectra, including an investigation of the evolution of the solenoidal and compressional components. We obtain a shallow density power spectrum with a slope of ~-1.2 attributed to the presence of a network of localised dense filamentary structures formed by strong shock interactions. The total velocity power spectrum slope is found to be ~-2.0, representative of Burgers shock dominated turbulence model. The density weighted velocity power spectrum slope is measured as ~-1.6, slightly less than the expected Kolmogorov scaling value (slope of -5/3) found in previous works. The discrepancy may be caused by the nature of our real space driving model and we suggest ther...

In this paper we explore the relationship between protostellar outflows and turbulence in molecular clouds. Using 3-D numerical simulations we focus on the hydrodynamics of multiple outflows interacting within a parsec scale volume. We explore the extent to which transient outflows injecting directed energy and momentum into a sub-volume of a molecular cloud can be converted into random turbulent motions. We show that turbulence can readily be sustained by these interactions and show that it is possible to broadly characterize an effective driving scale of the outflows. We compare the velocity spectrum obtained in our studies to that of isotropically forced hydrodynamic turbulence finding that in outflow driven turbulence a power law is indeed achieved. However we find a steeper spectrum (beta ~ 3) is obtained in outflow driven turbulence models than in isotropically forced simulations (beta ~ 2). We discuss possible physical mechanisms responsible for these results as well and their implications for turbulence in molecular clouds where outflows will act in concert with other processes such as gravitational collapse.

We have gained tremendous experience with the NuMI Project on what was a new level of neutrino beams from a high power proton source. We expect to build on that experience for any new long baseline neutrino beam. In particular, we have learned about some things which have worked well and/or where the experience is fairly directly applicable to the next project (e.g., similar civil construction issues including: tunneling, service buildings, outfitting, and potential claims/legal issues). Some things might be done very differently (e.g., decay pipe, windows, target, beam dump, and precision of power supply control/monitoring). The NuMI experience does lead to identification of critical items for any future such project, and what issues it will be important to address. The DUSEL Beamline Working Group established at Fermilab has been meeting weekly to collect and discuss information from that NuMI experience. This document attempts to assemble much of that information in one place. In this Executive Summary, we group relevant discussion of some of the major issues and lessons learned under seven categories: (1) Differences Between the NuMI Project and Any Next Project; (2) The Process of Starting Up the Project; (3) Decision and Review Processes; (4) ES&H: Environment, Safety, and Health; (5) Local Community Buy-In; (6) Transition from Project Status to Operation; and (7) Some Lessons on Technical Elements. We concentrate here on internal project management issues, including technical areas that require special attention. We cannot ignore, however, two major external management problems that plagued the NuMI project. The first problem was the top-down imposition of an unrealistic combination of scope, cost, and schedule. This situation was partially corrected by a rebaselining. However, the full, desirable scope was never achievable. The second problem was a crippling shortage of resources. Critical early design work could not be done in a timely fashion, leading to schedule delays, inefficiencies, and corrective actions. The Working Group discussions emphasized that early planning and up-front appreciation of the problems ahead are very important for minimizing the cost and for the greatest success of any such project. Perhaps part of the project approval process should re-enforce this need. The cost of all this up-front work is now reflected in the DOE cost of any project we do. If we are being held to an upper limit on the project cost, the only thing available for compromise is the eventual project scope.

Integrative structural biology models the structures of protein complexes that are intractable by classical structural methods (because of extreme size, dynamics, or heterogeneity) by combining computational structural modeling with data from experimental methods. One such method is chemical cross-linking mass spectrometry (XL-MS), in which cross-linked peptides, derived from a covalently cross-linked protein complex and identified by liquid chromatography-mass spectrometry, pinpoint protein residues close in three-dimensional space. The commonly used lysine-reactive N-hydroxysuccinimide ester reagents disuccinimidylsuberate (DSS) and bis(sulfosuccinimidyl)suberate (BS3) have a linker arm that is 11.4 Å long when fully extended. However, XL-MS studies on proteins of known structure frequently report cross-links that exceed this distance. Typically, a tolerance of ~3 Å is added to the theoretical maximum to account for this observation, with little justification for the value chosen. We used the Dynameomics database, a repository of high-quality molecular dynamics simulations of 807 proteins representative of all protein folds, to investigate the change in lysine-lysine distances resulting from native-state dynamics on the time-scale of tens of nanoseconds. We conclude that observed cross-links are consistent with a protein structure if the distance between cross-linked lysine N? atoms is less than the cross-linker length plus 11.3 Å. For DSS or BS3, this corresponds to a C? to C? distance of 30.4 Å. This analysis provides a theoretical basis for the widespread practice of adding a tolerance to the crosslinker length when comparing XL-MS results to structures, and indicates the appropriate values of an XLMS derived distance constraint to use in structural modeling.

Fast coronal mass ejections (CMEs) generate standing or bow shocks as they propagate through the corona and solar wind. Although CME shocks have previously been detected indirectly via their emission at radio frequencies, direct imaging has remained elusive due to their low contrast at optical wavelengths. Here we report the first images of a CME-driven shock as it propagates through interplanetary space from 8 R{sub sun} to 120 R{sub sun} (0.5 AU), using observations from the STEREO Heliospheric Imager. The CME was measured to have a velocity of {approx}1000 km s{sup -1} and a Mach number of 4.1 {+-} 1.2, while the shock front standoff distance ({Delta}) was found to increase linearly to {approx}20 R{sub sun} at 0.5 AU. The normalized standoff distance ({Delta}/D{sub O} ) showed reasonable agreement with semi-empirical relations, where D{sub O} is the CME radius. However, when normalized using the radius of curvature, {Delta}/R{sub O} did not agree well with theory, implying that R{sub O} was underestimated by a factor of {approx}3-8. This is most likely due to the difficulty in estimating the larger radius of curvature along the CME axis from the observations, which provide only a cross-sectional view of the CME.

We use a strain description to couple long-range elastic fields adiabatically to electronic density to describe the behavior of a quantum particle in an elastic medium. We show that in this generalization of the Holstein polaron problem, a bound polaronic state results with strong long-range angular dependence in the elastic fields, but a localized electronic core. The deformation of the elastic fields creates an anisotropic, indirect interaction between polarons extending to large distances. For a given density of polarons, this interaction favors the formation of strings of polarons in preferred directions.

A scanning optical microscope, including: a light source to generate a beam of probe light; collimation optics to substantially collimate the probe beam; a probe-result beamsplitter; a long working-distance, infinity-corrected objective; scanning means to scan a beam spot of the focused probe beam on or within a sample; relay optics; and a detector. The collimation optics are disposed in the probe beam. The probe-result beamsplitter is arranged in the optical paths of the probe beam and the resultant light from the sample. The beamsplitter reflects the probe beam into the objective and transmits resultant light. The long working-distance, infinity-corrected objective is also arranged in the optical paths of the probe beam and the resultant light. It focuses the reflected probe beam onto the sample, and collects and substantially collimates the resultant light. The relay optics are arranged to relay the transmitted resultant light from the beamsplitter to the detector.

We investigate the randomized and quantum communication complexity of the Hamming Distance problem, which is to determine if the Hamming distance between two n-bit strings is no less than a threshold d. We prove a quantum lower bound of \\Omega(d) qubits in the general interactive model with shared prior entanglement. We also construct a classical protocol of O(d \\log d) bits in the restricted Simultaneous Message Passing model, improving previous protocols of O(d^2) bits (A. C.-C. Yao, Proceedings of the Thirty-Fifth Annual ACM Symposium on Theory of Computing, pp. 77-81, 2003), and O(d\\log n) bits (D. Gavinsky, J. Kempe, and R. de Wolf, quant-ph/0411051, 2004).

A simplified theory, previously developed for the general case of weakly ionized gas flow, is used to predict electrical probe response when the flame is quenched on the probe surface. This theory is based on the planar model of space charge sheaths around the measuring electrode. For the flame quenching case, by assuming that the sheath thickness is comparable with the thermal boundary layer thickness, probe current can be related to flame quenching distance. The theoretical assumptions made to obtain the analytical formulation of probe current were experimentally proved by using direct visualization and high-frequency PIV. The direct visualization method was also used to validate the results of flame quenching distance values obtained with electrical probe. The electrical probe diagnostics have been verified for both head-on and sidewall flame quenching regimes and for stoichiometric methane/air and propane/air mixtures in a pressure range of 0.05-0.6 MPa. (author)

Standard lattice calculations in flavour physics or in studies of hadronic structure are based on the evaluation of matrix elements of local composite operators between hadronic states or the vacuum. In this talk I discuss developments aimed at the computation of long-distance, and hence non-local, contributions to such processes. In particular, I consider the calculation of the $K_L$-$K_S$ mass difference $\\Delta m_K=m_{K_L}-m_{K_S}$ and the amplitude for the rare-kaon decay processes $K\\to\\pi\\ell^+\\ell^-$, where the lepton $\\ell=e$ or $\\mu$. Lattice calculations of the long-distance contributions to the indirect $CP$-violating parameter $\\epsilon_K$ and to the rare decays $K\\to\\pi\

We obtain the following characterization of $Q$-polynomial distance-regular graphs. Let $\\G$ denote a distance-regular graph with diameter $d\\ge 3$. Let $E$ denote a minimal idempotent of $\\G$ which is not the trivial idempotent $E_0$. Let $\\{\\theta_i^*\\}_{i=0}^d$ denote the dual eigenvalue sequence for $E$. We show that $E$ is $Q$-polynomial if and only if (i) the entry-wise product $E \\circ E$ is a linear combination of $E_0$, $E$, and at most one other minimal idempotent of $\\G$; (ii) there exists a complex scalar $\\beta$ such that $\\theta^*_{i-1}-\\beta \\theta^*_i + \\theta^*_{i+1}$ is independent of $i$ for $1 \\le i \\le d-1$; (iii) $\\theta^*_i \

This article introduces a set of distance education astronomy laboratory exercises for use by college students and instructors and discuss first usage results. This General Astronomy Education Source (GEAS) exercise set contains eight two-week projects designed to guide students through both core content and mathematical applications of general astronomy material. Projects are divided between hands-on activities and computer-aided analyses of modern astronomical data. The suite of online resources includes student and instructor guides, laboratory report templates, learning objectives, video tutorials, plotting tools, and web-based applications that allow students to analyze both images and spectra of astronomical objects. A pilot usage study indicates that distance learners using these materials perform as well or better than a comparison cohort of on-campus students. We are actively seeking collaborators to use these resources in astronomy courses and other educational venues.

An attempt to answer the question 'Can we observe galaxies that recede faster than light ?' led to a re-examination of the notions of time, distance, velocity and redshift as they occur in newtonian physics, special relativity, general relativity and cosmology. A number of misconceptions were uncovered. It was found that, once freed of special relativity preconceptions, the above question is easily and unequivocally answered

For x-ray spot sizes of a few tens of microns or smaller, a millimeter-sized flat analyzer crystal placed {approx}1 cm from the sample will exhibit high energy resolution while subtending a collection solid angle comparable to that of a typical spherically bent crystal analyzer (SBCA) at much larger working distances. Based on this observation and a nonfocusing geometry for the analyzer optic, we have constructed and tested a short working distance (SWD) multicrystal x-ray spectrometer. This prototype instrument has a maximum effective collection solid angle of 0.14 sr, comparable to that of 17 SBCA at 1 m working distance. We find good agreement with prior work for measurements of the Mn K{beta} x-ray emission and resonant inelastic x-ray scattering for MnO, and also for measurements of the x-ray absorption near-edge structure for Dy metal using L{alpha}{sub 2} partial-fluorescence yield detection. We discuss future applications at third- and fourth-generation light sources. For concentrated samples, the extremely large collection angle of SWD spectrometers will permit collection of high-resolution x-ray emission spectra with a single pulse of the Linac Coherent Light Source. The range of applications of SWD spectrometers and traditional multi-SBCA instruments has some overlap, but also is significantly complementary.

Long-chain polyenes can be used as molecular wires to facilitate electron transfer between a photo-excited donor and an acceptor in an artificial photosynthetic system. The authors present data here on two Zn-porphyrin-polyene-anthraquinone molecules possessing either 5 or 9 all trans double bonds between the donor and acceptor, 1 and 2. The center-to-center distances between the porphyrin and the quinone in these relatively rigid molecules are 25 A for 1 and 35 A for 2. Selective picosecond laser excitation of the Zn-porphyrin in 1 and 2 results in the very rapid transfer of an electron to the anthraquinone in < 2 ps and 10 ps, respectively. The resultant radical ion pairs recombine with tau = 10 ps for 1 and tau = 25 ps for 2. The electron transfer rates remain remarkably rapid over these long distances. The involvement of polyene radical cations in the mechanism of the radical ion pair recombination reaction is clear from the transient absorption spectra of 1 and 2, which show strong absorbances in the near-infrared. The strong electronic coupling between the Zn-porphyrin and the anthraquinone provided by low-lying states of the polyene make it possible to transfer an electron rapidly over very long distances.

Standard cosmological models based on general relativity (GR) with dark energy predict that the Universe underwent a transition from decelerating to accelerating expansion at a moderate redshift $z_{acc} \\sim 0.7$. Clearly, it is of great interest to directly measure this transition in a model-independent way, without the assumption that GR is the correct theory of gravity. We explore to what extent supernova (SN) luminosity distance measurements provide evidence for such a transition: we show that, contrary to intuition, the well-known "turnover" in the SN distance residuals $\\Delta\\mu$ relative to an empty (Milne) model does not give firm evidence for such a transition within the redshift range spanned by SN data. The observed turnover in that diagram is predominantly due to the negative curvature in the Milne model, {\\em not} the deceleration predicted by $\\Lambda$CDM and relatives. We show that there are several advantages in plotting distance residuals against a flat, non-accelerating model $(w = -1/3)$,...

Many researchers have performed cosmological-model-independent tests for the distance-duality (DD) relation. Theoretical work has been conducted based on the results of these tests. However, we find that almost all of these tests were perhaps not cosmological-model-independent after all, because the distance moduli taken from a given type Ia supernovae (SNe Ia) compilation are dependent on a given cosmological model and Hubble constant. In this Letter, we overcome these defects and by creating a new cosmological-model-independent test for the DD relation. We use the original data from the Union2 SNe Ia compilation and the angular diameter distances from two galaxy cluster samples compiled by De Filippis et al. and Bonamente et al. to test the DD relation. Our results suggest that the DD relation is compatible with observations, and the spherical model is slightly better than the elliptical model at describing the intrinsic shape of galaxy clusters if the DD relation is valid. However, these results are different from those of previous work.

Conventional nuclear reactors use enriched Uranium as fuel and produce nuclear waste which needs to be stored away for over 10,000 years. At the current rate of use, existing sources of Uranium will last for 50-100 years. We describe a solution to the problem that uses particle accelerators to produce fast neutrons that can be used to burn existing nuclear waste and produce energy. Such systems, initially proposed by Carlo Rubbia and collaborators in the 1990's, are being seriously considered by many countries as a possible solution to the green energy problem. Accelerator driven reactors operate in a sub-critical regime and, thus, are safer and can obtain energy from plentiful elements such as Thorium-232 and Uranium-238. What is missing is the high intensity (10MW) accelerator that produces 1 GeV protons. We will describe scenarios which if implemented will make such systems a reality.

Conventional nuclear reactors use enriched Uranium as fuel and produce nuclear waste which needs to be stored away for over 10,000 years. At the current rate of use, existing sources of Uranium will last for 50-100 years. We describe a solution to the problem that uses particle accelerators to produce fast neutrons that can be used to burn existing nuclear waste and produce energy. Such systems, initially proposed by Carlo Rubbia and collaborators in the 1990's, are being seriously considered by many countries as a possible solution to the green energy problem. Accelerator driven reactors operate in a sub-critical regime and, thus, are safer and can obtain energy from plentiful elements such as Thorium-232 and Uranium-238. What is missing is the high intensity (10MW) accelerator that produces 1 GeV protons. We will describe scenarios which if implemented will make such systems a reality.

One fundamental element of scientific inquiry is discoveringrelationships, particularly the interactions between different variablesin observed or simulated phenomena. Building upon our prior work in thefield of Query-Driven Visualization, where visual data analysisprocessing is focused on subsets of large data deemed to be"scientifically interesting," this new work focuses on a novel knowledgediscovery capability suitable for use with petascale class datasets. Itenables visual presentation of the presence or absence of relationships(correlations) between variables in data subsets produced by Query-Drivenmethodologies. This technique holds great potential for enablingknowledge discovery from large and complex datasets currently emergingfrom SciDAC and INCITE projects. It is sufficiently generally to beapplicable to any time of complex, time-varying, multivariate data fromstructured, unstructured or adaptive grids.

Conventional nuclear reactors use enriched Uranium as fuel and produce nuclear waste which needs to be stored away for over 10,000 years. At the current rate of use, existing sources of Uranium will last for 50-100 years. We describe a solution to the problem that uses particle accelerators to produce fast neutrons that can be used to burn existing nuclear waste and produce energy. Such systems, initially proposed by Carlo Rubbia and collaborators in the 1990's, are being seriously considered by many countries as a possible solution to the green energy problem. Accelerator driven reactors operate in a sub-critical regime and, thus, are safer and can obtain energy from plentiful elements such as Thorium-232 and Uranium-238. What is missing is the high intensity (10MW) accelerator that produces 1 GeV protons. We will describe scenarios which if implemented will make such systems a reality.

Synchronization is a universal phenomenon found in many non-equilibrium systems. Much recent interest in this area has overlapped with the study of complex networks, where a major focus is determining how a system's connectivity patterns affect the types of behavior that it can produce. Thus far, modeling efforts have focused on the tendency of networks of oscillators to mutually synchronize themselves, with less emphasis on the effects of external driving. In this work we discuss the interplay between mutual and driven synchronization in networks of phase oscillators of the Kuramoto type, and resolve how the structure and emergence of such states depends on the underlying network topology for simple random networks with a given degree distribution. We provide a partial bifurcation analysis, centering on the appearance of a Takens-Bogdanov-Cusp singularity, which broadly separates homogeneous and heterogeneous network behavior in a weak coupling limit, and from which the number, stability and appearance of dr...

of approximately 170. I. INTRODUCTION HE Diocles laser facility at The University of Nebraska- Lincoln (UNL is with the Department of Nuclear Engineering and Radiological Sciences of the University of Michigan, Ann Arbor, MI and Radiological Sciences of the University of Michigan, Ann Arbor, MI 48109 USA (tel: 734-615-7830, e

Frameworks for Business-driven Service Level Management A Criteria-based Comparison of ITIL-driven IT Management: the IT Infrastructure Library (ITIL) with its SLM reference process and the NGOSS SLA Management a realistic IT scenario. These criteria are applied to ITIL and NGOSS in order to elaborate possible areas

SINGULARITIES IN HELEÂ­SHAW FLOWS DRIVEN BY A MULTIPOLE QING NIE AND FEI-RAN TIAN SIAM J. APPL. MATH, analytically and numerically, singularity formation in an interface flow driven by a multipole for a two in the case of a dipole. For a multipole of a higher order, we show that the solution does not tend to any

the existence of a linearly undamped component of the flow which could build up in time and lower the finalThe Dynamics of Small­Scale Turbulence Driven Flows M. A. Beer and G. W. Hammett PPPL APS DPP meeting, November 1997 The dynamics of small­scale fluctuation driven flows are of great in­ terest

One of the design basis accidents for the Next Generation Nuclear Plant (NGNP), a high temperature gas-cooled reactor, is air ingress subsequent to a pipe break. Following a postulated double-ended guillotine break in the hot duct, and the subsequent depressurization to nearly reactor cavity pressure levels, air present in the reactor cavity will enter the reactor vessel via density-gradient-driven-stratified flow. Because of the significantly higher molecular weight and lower initial temperature of the reactor cavity air-helium mixture, in contrast to the helium in the reactor vessel, the air-helium mixture in the cavity always has a larger density than the helium discharging from the reactor vessel through the break into the reactor cavity. In the later stages of the helium blowdown, the momentum of the helium flow decreases sufficiently for the heavier cavity air-helium mixture to intrude into the reactor vessel lower plenum through the lower portion of the break. Once it has entered, the heavier gas will pool at the bottom of the lower plenum. From there it will move upwards into the core via diffusion and density-gradient effects that stem from heating the air-helium mixture and from the pressure differences between the reactor cavity and the reactor vessel. This scenario (considering density-gradient-driven stratified flow) is considerably different from the heretofore commonly used scenario that attributes movement of air into the reactor vessel and from thence to the core region via diffusion. When density-gradient-driven stratified flow is considered as a contributing phenomena for air ingress into the reactor vessel, the following factors contribute to a much earlier natural circulation-phase in the reactor vessel: (a) density-gradient-driven stratified flow is a much more rapid mechanism (at least one order of magnitude) for moving air into the reactor vessel lower plenum than diffusion, and consequently, (b) the diffusion dominated phase begins with a much larger flow area and a much shorter distance for air to move into the core than earlier scenarios that attribute all air ingress from the reactor cavity into the core to diffusion only. Hence, consideration of the density-gradient-driven stratified flow phenomena will likely lead to more rapid air ingress into the core and also the presence of more air for core graphite oxidation than the widely-used air ingress attributed solely to diffusion. This paper discusses the density-gradient-driven stratified flow phenomena and the implications of considering this behavior on the progression of the air ingress event. Preliminary calculations are used to underline the importance of considering the density-gradient driven stratified flow phenomena in subsequent validation experiments and software development for analyzing VHTR scenarios.

This fact sheet highlights the Mitsubishi iMiEV, an electric mini-car in the advanced technology vehicle fleet at the National Renewable Energy Laboratory (NREL). In support of the U.S. Department of Energy's fast-charging research efforts, NREL engineers are conducting charge and discharge performance testing on the vehicle. NREL's advanced technology vehicle fleet features promising technologies to increase efficiency and reduce emissions without sacrificing safety or comfort. The fleet serves as a technology showcase, helping visitors learn about innovative vehicles that are available today or are in development. Vehicles in the fleet are representative of current, advanced, prototype, and emerging technologies.

This work investigates theoretically the efficiency with which heat may be converted into resonance radiation in a cesium thermionic diode. An analytical model of a thermionic converter is employed which combines the coupled effects of line radiation transport, excited-state kinetics, and plasma diffusion. Operating regimes are established for various degrees of optical density in the plasma. The results indicate that monochromatic radiation can be produced with efficiencies on the order of 30 percent provided there is an adequate voltage drop across the plasma. In this study, a drop of one volt was used since it can be maintained without any electrical power input to the device. It is found that high efficiencies come by virtue of the higher interelectrode distances which the solutions will accommodate, and that radiation can be generated efficiently, even with optically dense gases.

Gamma ray bursts can potentially be used as distance indicators, providing the possibility of extending the Hubble diagram to redshifts ~7. Here we follow the analysis of Schaefer (2007), with the aim of distinguishing the timescape cosmological model from the \\LambdaCDM model by means of the additional leverage provided by GRBs in the range 2 < z < 7. We find that the timescape model fits the GRB sample slightly better than the \\LambdaCDM model, but that the systematic uncertainties are still too little understood to distinguish the models.

A high speed serial data transmission multiplexing circuit, which is operable to accurately transmit data over long distances (up to 3 Km), and to multiplex, select and continuously display real time analog signals in a bandwidth from DC to 100 Khz. The circuit is made fault tolerant by use of a programmable flywheel algorithm, which enables the circuit to tolerate one transmission error before losing synchronization of the transmitted frames of data. A method of encoding and framing captured and transmitted data is used which has a low overhead and prevents some particular transmitted data patterns from locking an included detector/decoder circuit.

Subcritical source-driven noise measurements are simultaneous Rossia and randomly pulsed neutron measurements that provide measured quantities that can be related to the subcritical neutron multiplication factor. In fact, subcritical source-driven noise measurements should be performed in lieu of Rossia measurements because of the additional information that is obtained from noise measurements such as the spectral ratio and the coherence functions. The basic understanding of source-driven noise analysis measurements can be developed from a point reactor kinetics model to demonstrate how the measured quantities relate to the subcritical neutron multiplication factor.

This report focuses on an approach to high performance visualization and analysis, termed query-driven visualization and analysis (QDV). QDV aims to reduce the amount of data that needs to be processed by the visualization, analysis, and rendering pipelines. The goal of the data reduction process is to separate out data that is "scientifically interesting'' and to focus visualization, analysis, and rendering on that interesting subset. The premise is that for any given visualization or analysis task, the data subset of interest is much smaller than the larger, complete data set. This strategy---extracting smaller data subsets of interest and focusing of the visualization processing on these subsets---is complementary to the approach of increasing the capacity of the visualization, analysis, and rendering pipelines through parallelism. This report discusses the fundamental concepts in QDV, their relationship to different stages in the visualization and analysis pipelines, and presents QDV's application to problems in diverse areas, ranging from forensic cybersecurity to high energy physics.

We consider our universe as a 3d domain wall embedded in a 5d dimensional Minkowski space-time. We address the problem of inflation and late time acceleration driven by bulk particles colliding with the 3d domain wall. The expansion of our universe is mainly related to these bulk particles. Since our universe tends to be permeated by a large number of isolated structures, as temperature diminishes with the expansion, we model our universe with a 3d domain wall with increasing internal structures. These structures could be unstable 2d domain walls evolving to fermi-balls which are candidates to cold dark matter. The momentum transfer of bulk particles colliding with the 3d domain wall is related to the reflection coefficient. We show a nontrivial dependence of the reflection coefficient with the number of internal dark matter structures inside the 3d domain wall. As the population of such structures increases the velocity of the domain wall expansion also increases. The expansion is exponential at early times and polynomial at late times. We connect this picture with string/M-theory by considering BPS 3d domain walls with structures which can appear through the bosonic sector of a five-dimensional supergravity theory.

Laser-driven acceleration holds great promise for significantly improving accelerating gradient. However, scaling the conventional process of structure-based acceleration in vacuum down to optical wavelengths requires a substantially different kind of structure. We require an optical waveguide that (1) is constructed out of dielectric materials, (2) has transverse size on the order of a wavelength, and (3) supports a mode with speed-of-light phase velocity in vacuum. Photonic crystals---structures whose electromagnetic properties are spatially periodic---can meet these requirements. We discuss simulated photonic crystal accelerator structures and describe their properties. We begin with a class of two-dimensional structures which serves to illustrate the design considerations and trade-offs involved. We then present a three-dimensional structure, and describe its performance in terms of accelerating gradient and efficiency. We discuss particle beam dynamics in this structure, demonstrating a method for keeping a beam confined to the waveguide. We also discuss material and fabrication considerations. Since accelerating gradient is limited by optical damage to the structure, the damage threshold of the dielectric is a critical parameter. We experimentally measure the damage threshold of silicon for picosecond pulses in the infrared, and determine that our structure is capable of sustaining an accelerating gradient of 300 MV/m at 1550 nm. Finally, we discuss possibilities for manufacturing these structures using common microfabrication techniques.

A data flow computer and method of computing is disclosed which utilizes a data driven processor node architecture. The apparatus in a preferred embodiment includes a plurality of First-In-First-Out (FIFO) registers, a plurality of related data flow memories, and a processor. The processor makes the necessary calculations and includes a control unit to generate signals to enable the appropriate FIFO register receiving the result. In a particular embodiment, there are three FIFO registers per node: an input FIFO register to receive input information from an outside source and provide it to the data flow memories; an output FIFO register to provide output information from the processor to an outside recipient; and an internal FIFO register to provide information from the processor back to the data flow memories. The data flow memories are comprised of four commonly addressed memories. A parameter memory holds the A and B parameters used in the calculations; an opcode memory holds the instruction; a target memory holds the output address; and a tag memory contains status bits for each parameter. One status bit indicates whether the corresponding parameter is in the parameter memory and one status bit to indicate whether the stored information in the corresponding data parameter is to be reused. The tag memory outputs a ''fire'' signal (signal R VALID) when all of the necessary information has been stored in the data flow memories, and thus when the instruction is ready to be fired to the processor. 11 figs.

A data flow computer which of computing is disclosed which utilizes a data driven processor node architecture. The apparatus in a preferred embodiment includes a plurality of First-In-First-Out (FIFO) registers, a plurality of related data flow memories, and a processor. The processor makes the necessary calculations and includes a control unit to generate signals to enable the appropriate FIFO register receiving the result. In a particular embodiment, there are three FIFO registers per node: an input FIFO register to receive input information form an outside source and provide it to the data flow memories; an output FIFO register to provide output information from the processor to an outside recipient; and an internal FIFO register to provide information from the processor back to the data flow memories. The data flow memories are comprised of four commonly addressed memories. A parameter memory holds the A and B parameters used in the calculations; an opcode memory holds the instruction; a target memory holds the output address; and a tag memory contains status bits for each parameter. One status bit indicates whether the corresponding parameter is in the parameter memory and one status but to indicate whether the stored information in the corresponding data parameter is to be reused. The tag memory outputs a "fire" signal (signal R VALID) when all of the necessary information has been stored in the data flow memories, and thus when the instruction is ready to be fired to the processor.

We study the well-posedness and dynamic transitions of the surface tension driven convection in a three-dimensional (3D) rectangular box with non-deformable upper surface and with free-slip boundary conditions. It is shown that as the Marangoni number crosses the critical threshold, the system always undergoes a dynamic transition. In particular, two different scenarios are studied. In the first scenario, a single mode losing its stability at the critical parameter gives rise to either a Type-I (continuous) or a Type-II (jump) transition. The type of transitions is dictated by the sign of a computable non-dimensional parameter, and the numerical computation of this parameter suggests that a Type-I transition is favorable. The second scenario deals with the case where the geometry of the domain allows two critical modes which possibly characterize a hexagonal pattern. In this case we show that the transition can only be either a Type-II or a Type-III (mixed) transition depending on another computable non-dimensional parameter. We only encountered Type-III transition in our numerical calculations. The second part of the paper deals with the well-posedness and existence of global attractors for the problem.

This thesis presents a comparative evaluation of different distance metrics and local planners within the context of probabilistic roadmap methods for motion planning. Both C-space and Workspace distance metrics and local planners are considered...

With the advent of "smart" consumer electronics, distance sensing is an increasingly important field in optical sensing. A novel approach to active infrared(IR) 1D distance sensing is proposed, employing both intensity and ...

The relation between the central mass and quasar luminosity (M_BH \\propto L^{\\alpha}FHWM^2) links a given Eddington ratio with a value of H_0, within a cosmology with fixed (\\Omega_m,\\Omega_{\\Lambda}). We point out that because the relation is calibrated at low z using distance independent reverberation mapping to get the BLR size, the derived M_BH interestingly does not depend on H_0, while L/L_Edd is sensitive to H_0, but rather robust to changes of \\Omega_{\\Lambda} in the standard flat model. This means, e.g., that enough of extragalactic objects radiating at the Eddington limit could be used to study the global Hubble constant in a new way, bypassing the local distance ladder. The method could become practical when systematic errors in derived M_BH are understood and objects with L /leq L_Edd can be independently identified. As an illustration, if we take a sample of tranquil very luminous quasars in the redshift range 0.5 < z < 1.6, and assume that they are radiating with L_bol \\leq L_Edd, then the usual numeric factors used for calculating M_BH and L_bol would lead to the result that the Hubble constant must be larger than 45 km/s/Mpc.

Using a sample of 608 Type Ia supernovae from the SDSS-II and BOSS surveys, combined with a sample of foreground galaxies from SDSS-II, we estimate the weak lensing convergence for each supernova line of sight. We find that the correlation between this measurement and the Hubble residuals is consistent with the prediction from lensing (at a significance of 1.7?). Strong correlations are also found between the residuals and supernova nuisance parameters after a linear correction is applied. When these other correlations are taken into account, the lensing signal is detected at 1.4?. We show, for the first time, that distance estimates from supernovae can be improved when lensing is incorporated, by including a new parameter in the SALT2 methodology for determining distance moduli. The recovered value of the new parameter is consistent with the lensing prediction. Using cosmic microwave background data from WMAP7, H {sub 0} data from Hubble Space Telescope and Sloan Digital Sky Survey (SDSS) Baryon acoustic oscillations measurements, we find the best-fit value of the new lensing parameter and show that the central values and uncertainties on ? {sub m} and w are unaffected. The lensing of supernovae, while only seen at marginal significance in this low-redshift sample, will be of vital importance for the next generation of surveys, such as DES and LSST, which will be systematics-dominated.

Algebraic multigrid (AMG) is one of the most efficient and scalable parallel algorithms for solving sparse linear systems on unstructured grids. However, for large three-dimensional problems, the coarse grids that are normally used in AMG often lead to growing complexity in terms of memory use and execution time per AMG V-cycle. Sparser coarse grids, such as those obtained by the Parallel Modified Independent Set coarsening algorithm (PMIS) [7], remedy this complexity growth, but lead to non-scalable AMG convergence factors when traditional distance-one interpolation methods are used. In this paper we study the scalability of AMG methods that combine PMIS coarse grids with long distance interpolation methods. AMG performance and scalability is compared for previously introduced interpolation methods as well as new variants of them for a variety of relevant test problems on parallel computers. It is shown that the increased interpolation accuracy largely restores the scalability of AMG convergence factors for PMIS-coarsened grids, and in combination with complexity reducing methods, such as interpolation truncation, one obtains a class of parallel AMG methods that enjoy excellent scalability properties on large parallel computers.

Wear data are presented for diamond tools cutting electroless nickel (eNi) for cut lengths up to 70,000 ft (13 miles). Two tools having different infrared absorption characteristics were used to cut an eNi preparation that had yielded minimum values for surface roughness and tool wear rate in a previous study. The data include Talystep measurement of the rms amplitude of the feed-marks versus cumulative cutting distance, representative examples of shape changes for the feed-mark profiles, SEM and optical micrographs of the tool rake and flank face wear zones, and measurements of the cutting edge profile and edge recession distance by a tool-nose replication technique. Feed-mark roughness values were found to increase from 5 to 90 A rms over the duration of the test, with an associated edge recession of about 1000 A and the development of a periodic tool edge grooving indicative of burnishing of the part surface. The ir absorption data successfully predicted the order of the two tools in terms of wear rate and fracture toughness.

A bioreactor landfill cell with 1.2-acre footprint was constructed, filled, operated, and monitored at Northern Oaks Recycling and Disposal Facility (NORDF) at Harrison, MI. With a filled volume of 74,239 cubic yards, the cell contained approximately 35,317 tons of municipal solid waste (MSW) and 20,777 tons of cover soil. It was laid on the slope of an existing cell but separated by a geosynthetic membrane liner. After the cell reached a design height of 60 feet, it was covered with a geosynthetic membrane cap. A three-dimensional monitoring system to collect data at 48 different locations was designed and installed during the construction phase of the bioreactor cell. Each location had a cluster of monitoring devices consisting of a probe to monitor moisture and temperature, a leachate collection basin, and a gas sampling port. An increase in moisture content of the MSW in the bioreactor cell was achieved by pumping leachate collected on-site from various other cells, as well as recirculation of leachate from the bioreactor landfill cell itself. Three types of leachate injection systems were evaluated in this bioreactor cell for their efficacy to distribute pumped leachate uniformly: a leachate injection pipe buried in a 6-ft wide horizontal stone mound, a 15-ft wide geocomposite drainage layer, and a 60-ft wide geocomposite drainage layer. All leachate injection systems were installed on top of the compacted waste surface. The distribution of water and resulting MSW moisture content throughout the bioreactor cell was found to be similar for the three designs. Water coming into and leaving the cell (leachate pumped in, precipitation, snow, evaporation, and collected leachate) was monitored in order to carry out a water balance. Using a leachate injection rate of 26 – 30 gal/yard3, the average moisture content increased from 25% to 35% (wet based) over the period of this study. One of the key aspects of this bioreactor landfill study was to evaluate bioreactor start up and performance in locations with colder climate. For lifts filled during the summer months, methane generation started within three months after completion of the lift. For lifts filled in winter months, very little methane production occurred even eight months after filling. The temperature data indicated that subzero or slightly above zero (oC) temperatures persisted for unusually long periods (more than six months) in the lifts filled during winter months. This was likely due to the high thermal insulation capability of the MSW and the low level of biological activity during start up. This observation indicates that bioreactor landfills located in cold climate and filled during winter months may require mechanisms to increase temperature and initiate biodegradation. Thus, besides moisture, temperature may be the next important factor controlling the biological decomposition in anaerobic bioreactor landfills. Spatial and temporal characterization of leachate samples indicated the presence of low levels of commonly used volatile organic compounds (including acetone, methyl ethyl ketone, methyl isobutyl ketone, and toluene) and metals (including arsenic, chromium, and zinc). Changes and leachate and gaseous sample characteristics correlated with enhanced biological activity and increase in temperature. Continued monitoring of this bioreactor landfill cell is expected to yield critical data needed for start up, design, and operation of this emerging process.

We make a direct test of Tully-Fisher distance estimates to eleven spiral galaxies with HST Cepheid distances and to twelve spiral galaxies with SNIa distances. The HST Cepheid distances come from the work of Freedman (1997), Sandage et al (1996) and Tanvir et al (1995). The SNIa distances come from Pierce (1994), calibrated using the Cepheid results of Sandage et al (1996). The Tully-Fisher distances mostly come from the work of Pierce (1994). The results show that the Tully-Fisher distance moduli are too short with respect to the Cepheid distances by 0.46+-0.14mag and too short with respect to the SNIa distances by 0.46+-0.19mag. Combining the HST Cepheid and SNIa data suggests that, overall, previous Tully-Fisher distances were too short by 0.46+-0.11mag, a result which is significant at the 4sigma level. These data therefore indicate that previous Tully-Fisher distances should be revised upwards by 24+-6% implying, for example, a Virgo distance of 19.3+-1.9Mpc. The value of Ho from Tully-Fisher estimates is correspondingly revised downwards from Ho=84+-10 to Ho=68+-8.

Naturally ventilated buildings can significantly reduce the required energy for cooling and ventilating buildings by drawing in outdoor air using non-mechanical forces. Buoyancy-driven systems are common in naturally ...

Many robotic hands have individually driven joints, which is both energy inefficient and complicated to control. An alternative method includes employing only one motor to control multiple joints. Investigating humanoid ...

This thesis explores the buoyancy-driven circulation in the Red Sea, using a combination of observations, as well as numerical modeling and analytical method. The first part of the thesis investigates the formation mechanism ...

In this study the geometry of a dual acting, magnetically driven, linear motion actuator will be optimized. This will be accomplished by modeling the system through a set of differential equations to be solved in Matlab. ...

An experimental study was conducted in order to verify the appropriateness of a two dimensional model of the flow creating diffusion driven object propulsion in density stratified fluids. Initial flow field experiments ...

Motivated by recent photoemission experiments on the surface of topological insulators we compute the spectrum of driven topological surface excitations in the presence of an external light source. We completely characterize ...

Theoretical calculations predict that by coupling an exothermic chemical reaction with a nanotube or nanowire possessing a high axial thermal conductivity, a self-propagating reactive wave can be driven along its length. ...

Direct real-time visualization and measurement of laser-driven shock generation, propagation, and 2D focusing in a sample are demonstrated. A substantial increase of the pressure at the convergence of the cylindrical ...

In this thesis, we study data-driven decision making in operation management contexts, with a focus on both theoretical and practical aspects. The first part of the thesis analyzes the well-known newsvendor model but under ...

A new computer-oriented approach for analyzing aquifer driven reservoirs incorporates both geological and historical pressure data to determine original hydrocarbons-in-place and to forecast production. This new approach does not rely entirely...

The principal objective of this thesis is to assess the capabilities of an already established analytical framework for understanding and predicting the behavior of piles driven in highly overconsolidated clays (OCR24). ...

May 12, 2006 ... Robust and Data-Driven Optimization: Modern Decision-Making Under ... The purpose of this tutorial is to present a mathematical framework that is well-suited to the limited information ... Visitors, Authors, More about us, Links.

A STUDY OF WATER DRIVEN OIL ENCROACHMENT INTO GAS CAPS LIBRARY A S I COLLEGE OF TEXAS A Thesis By HARLAN J. RITCH ~ ~ ~ Submitted to the Graduate School oi' the Agricultural and Mechanical College of Texas in partial fulfillment... of the requirements for the degree of MASTER OF SCIENCE May, 1958 Major Subject: Petroleum Engineering A STUDY OF WATER DRIVEN OIL ENCROACHMENT INTO GAS CAPS A Thesis By HARLAN J. RITCH Approved as to style and content by: hairxnan of Coxnxnittee) (Head...

Three zinc tetraphenylporphyrin-anthraquinone derivatives were prepared in which the edge-to-edge distances between the porphyrin and quinone ..pi.. systems are fixed by a rigid hydrocarbon spacer molecule. Triptycene, trans-1,2-diphenylcyclopentane, and adamantane were used to fix the porphyrin-anthraquinone distance at 2.5, 3.7, and 4.9 A, respectively. These molecules possess 1,2, and 3 saturated carbon atoms, respectively, between the porphyrin donor and the quinone acceptor. Rate constants for photoinduced electron transfer from the lowest excited singlet state of the zinc tetraphenylporphyrin donor to the anthraquinone acceptor were measured. In addition, the corresponding radical ion pair recombination rate constants for each of these molecules were also determined. The rate constants for both photoinduced charge separation and subsequent radical ion pair recombination decrease by approximately a factor of 10 for each saturated carbon atom intervening between the porphyrin donor and the quinone acceptor. These results are consistent with a model in which the rate of electron transfer is determined by weak mixing of the sigma orbitals of the saturated hydrocarbon spacer with the ..pi.. orbitals of the donor and acceptor. 22 refs., 5 figs.

From the adoption of the Model Additional Protocol and integrated safeguards in the 1990s, to current International Atomic Energy Agency (IAEA) efforts to deal with cases of noncompliance, the question of how the Agency can best utilize all the information available to it remains of great interest and increasing importance. How might the concept of 'information-driven' safeguards (IDS) evolve in the future? The ability of the Agency to identify and resolve anomalies has always been important and has emerged as a core Agency function in recent years as the IAEA has had to deal with noncompliance in Iran and the Democratic People's Republic of Korea (DPRK). Future IAEA safeguards implementation should be designed with the goal of facilitating and enhancing this vital capability. In addition, the Agency should utilize all the information it possesses, including its in-house assessments and expertise, to direct its safeguards activities. At the State level, knowledge of proliferation possibilities is currently being used to guide the analytical activities of the Agency and to develop inspection plans. How far can this approach be extended? Does it apply across State boundaries? Should it dictate a larger fraction of safeguards activities? Future developments in IDS should utilize the knowledge resident within the Agency to ensure that safeguards resources flow to where they are most needed in order to address anomalies first and foremost, but also to provide greater confidence in conclusions regarding the absence of undeclared nuclear activities. The elements of such a system and related implementation issues are assessed in this paper.

NERSC has developed a five-year strategic plan focusing on three components: Science-Driven Systems, Science-Driven Services, and Science-Driven Analytics. (1) Science-Driven Systems: Balanced introduction of the best new technologies for complete computational systems--computing, storage, networking, visualization and analysis--coupled with the activities necessary to engage vendors in addressing the DOE computational science requirements in their future roadmaps. (2) Science-Driven Services: The entire range of support activities, from high-quality operations and user services to direct scientific support, that enable a broad range of scientists to effectively use NERSC systems in their research. NERSC will concentrate on resources needed to realize the promise of the new highly scalable architectures for scientific discovery in multidisciplinary computational science projects. (3) Science-Driven Analytics: The architectural and systems enhancements and services required to integrate NERSC's powerful computational and storage resources to provide scientists with new tools to effectively manipulate, visualize, and analyze the huge data sets derived from simulations and experiments.

We study the performance of distance-three surface code layouts under realistic multi-parameter noise models. We first calculate their thresholds under depolarizing noise. We then compare a Pauli-twirl approximation of amplitude and phase damping to amplitude and phase damping. We find the approximate channel results in a pessimistic estimate of the logical error rate, indicating the realistic threshold may be higher than previously estimated. From Monte-Carlo simulations, we identify experimental parameters for which these layouts admit reliable computation. Due to its low resource cost and superior performance, we conclude that the 17-qubit layout should be targeted in early experimental implementations of the surface code. We find that architectures with gate times in the 5-40 ns range and T1 times of at least 1-2 us range will exhibit improved logical error rates with a 17-qubit surface code encoding.

Accurate delivery of small targets in high vacuum is a pivotal task in many branches of science and technology. Beyond the different strategies developed for atoms, proteins, macroscopic clusters and pellets, the manipulation of neutral particles over macroscopic distances still poses a formidable challenge. Here we report a novel approach based on a mobile optical trap operated under feedback control that enables long range 3D manipulation of a silica nanoparticle in high vacuum. We apply this technique to load a single nanoparticle into a high-finesse optical cavity through a load-lock vacuum system. We foresee our scheme to benefit the field of optomechanics with levitating nano-objects as well as ultrasensitive detection and monitoring.

An important problem in quantum information theory is the quantification of entanglement in multipartite mixed quantum states. In this work, a connection between the geometric measure of entanglement and a distance measure of entanglement is established. We present a new expression for the geometric measure of entanglement in terms of the maximal fidelity with a separable state. A direct application of this result provides a closed expression for the Bures measure of entanglement of two qubits. We also prove that the number of elements in an optimal decomposition w.r.t. the geometric measure of entanglement is bounded from above by the Caratheodory bound, and we find necessary conditions for the structure of an optimal decomposition.

An important problem in quantum information theory is the quantification of entanglement in multipartite mixed quantum states. In this work a connection between the geometric measure of entanglement and a distance measure of entanglement is established. We present a new expression for the geometric measure of entanglement in terms of the maximal fidelity with a separable state. A direct application of this result provides a closed expression for the Bures measure of entanglement of two qubits. We also prove that the number of elements in an optimal decomposition with respect to the geometric measure of entanglement is bounded from above by the Caratheodory bound, and we find necessary conditions for the structure of an optimal decomposition.

A major recent evelopment in observational cosmology has been an accurate measurement of the luminosity distance-redshift relation out to redshifts z=0.8 from Type Ia supernova standard candles. The results have been argued as evidence for cosmic acceleration. It is well known that this assertion depends on the assumption that we know the equation of state for all mass-energy other than normal pressureless matter; popular models are based on either the cosmological constant or on the more general quintessence formulation. But this assertion also depends on a number of other assumptions, implicit in the derivation of the standard cosmological field equations: large-scale isotropy and homogeneity, the flatness of the Universe, and the validity of general relativity on cosmological scales (where it has not been tested). A detailed examination of the effects of these assumptions on the interplay between the luminosity distance-redshift relation and the acceleration of the Universe is not possible unless one can define the precise nature of the failure of any particular assumption. However a simple quantitative investigation is possible and reveals a number of considerations about the relative importance of the different assumptions. In this paper we present such an investigation. We find that the relationship between the distant-redshift relation and the sign of the deceleration parameter is fairly robust and is unaffected if only one of the assumptions that we investigate is invalid so long as the deceleration parameter is not close to zero (it would not be close to zero in the currently-favored Omega_Lambda = 1 - Omega_matter = 0.7 or 0.8 Universe, for example). Failures of two or more assumptions in concordance may have stronger effects.

Air-conditioning (cooling) for buildings is the single largest use of electricity in the United States (U.S.). This drives summer peak electric demand in much of the U.S. Improved air-conditioning technology thus has the greatest potential impact on the electric grid compared to other technologies that use electricity. Thermally-activated technologies (TAT), such as natural gas engine-driven heat pumps (GHP), can provide overall peak load reduction and electric grid relief for summer peak demand. GHP offers an attractive opportunity for commercial building owners to reduce electric demand charges and operating expenses. Engine-driven systems have several potential advantages over conventional single-speed or single-capacity electric motor-driven units. Among them are variable speed operation, high part load efficiency, high temperature waste heat recovery from the engine, and reduced annual operating costs (SCGC 1998). Although gas engine-driven systems have been in use since the 1960s, current research is resulting in better performance, lower maintenance requirements, and longer operating lifetimes. Gas engine-driven systems are typically more expensive to purchase than comparable electric motor-driven systems, but they typically cost less to operate, especially for commercial building applications. Operating cost savings for commercial applications are primarily driven by electric demand charges. GHP operating costs are dominated by fuel costs, but also include maintenance costs. The reliability of gas cooling equipment has improved in the last few years and maintenance requirements have decreased (SCGC 1998, Yahagi et al. 2006). Another advantage of the GHP over electric motor-driven is the ability to use the heat rejected from the engine during heating operation. The recovered heat can be used to supplement the vapor compression cycle during heating or to supply other process loads, such as water heating. The use of the engine waste heat results in greater operating efficiency compared to conventional electric motor-driven units (SCGC 1998). In Japan, many hundreds of thousands of natural gas-driven heat pumps have been sold (typically 40,000 systems annually) (Yahagi et al. 2006). The goal of this program is to develop dependable and energy efficient GHPs suitable for U.S. commercial rooftop applications (the single largest commercial product segment). This study describes the laboratory performance evaluation of an integrated 10-ton GHP rooftop unit (a 900cc Daihatsu-Aisin natural gas engine) which uses R410A as the refrigerant (GEDAC No.23). ORNL Thermally-Activated Heat Pump (TAHP) Environmental Chambers were used to evaluate this unit in a controlled laboratory environment.

Here, we document a collection of ~7434 MiMIC (Minos Mediated Integration Cassette) insertions of which 2854 are inserted in coding introns. They allowed us to create a library of 400 GFP-tagged genes. We show that 72% of internally tagged proteins are functional, and that more than 90% can be imaged in unfixed tissues. Moreover, the tagged mRNAs can be knocked down by RNAi against GFP (iGFPi), and the tagged proteins can be efficiently knocked down by deGradFP technology. The phenotypes associated with RNA and protein knockdown typically correspond to severe loss of function or null mutant phenotypes. Finally, we demonstratemore »reversible, spatial, and temporal knockdown of tagged proteins in larvae and adult flies. This new strategy and collection of strains allows unprecedented in vivo manipulations in flies for many genes. These strategies will likely extend to vertebrates.« less

Modulation of North Pacific Tropical Cyclone Activity by Three Phases of ENSO HYE-MI KIM, PETER J Pacific Ocean warming has been separated into two modes based on the spatial distribution of the maximum impacts on tropical cyclone (TC) activity over the North Pacific by differential modulation of both local

Michigan State University Community Music School 841-B Timberlane Street · East Lansing, MI 48823 Explore Michigan's past through tour of music, exhibits May 1 Contact: Amanda Darche, MSU Community Music School (517) 355-7661, ext. 16, adarche@msu.edu EAST LANSING, Mich. ­Michigan's past is the inspiration

The purpose of this report is to summarize and evaluate the Argonne Distance Tabletop Exercise (DISTEX) method. DISTEX is intended to facilitate multi-organization, multi-objective tabletop emergency response exercises that permit players to participate from their own facility's incident command center. This report is based on experience during its first use during the FluNami 2007 exercise, which took place from September 19-October 17, 2007. FluNami 2007 exercised the response of local public health officials and hospitals to a hypothetical pandemic flu outbreak. The underlying purpose of the DISTEX method is to make tabletop exercising more effective and more convenient for playing organizations. It combines elements of traditional tabletop exercising, such as scenario discussions and scenario injects, with distance learning technologies. This distance-learning approach also allows playing organizations to include a broader range of staff in the exercise. An average of 81.25 persons participated in each weekly webcast session from all playing organizations combined. The DISTEX method required development of several components. The exercise objectives were based on the U.S. Department of Homeland Security's Target Capabilities List. The ten playing organizations included four public health departments and six hospitals in the Chicago area. An extent-of-play agreement identified the objectives applicable to each organization. A scenario was developed to drive the exercise over its five-week life. Weekly problem-solving task sets were designed to address objectives that could not be addressed fully during webcast sessions, as well as to involve additional playing organization staff. Injects were developed to drive play between webcast sessions, and, in some cases, featured mock media stories based in part on player actions as identified from the problem-solving tasks. The weekly 90-minute webcast sessions were discussions among the playing organizations that were moderated by a highly-qualified public health physician, who reviewed key scenario developments and player actions, as well as solicited input from each playing organization. The exercise control structure included trusted agents who oversaw exercise planning, playing organization points of contact to ensure exercise coordination, and exercise controller/evaluators to initiate and oversee exercise play. A password-protected exercise website was designed for FluNami 2007 to serve as a compartmentalized central information source, and for transmitting exercise documents. During the course of FluNami 2007, feedback on its quality was collected from players and controller/evaluators. Player feedback was requested at the conclusion of each webcast, upon completion of each problem-solving task, and on October 17, 2007, after the final webcast session had ended. The overall average score given to FluNami 2008 by the responding players was 3.9 on a five-point scale. In addition, suggestions for improving the process were provided by Argonne controller/evaluators after the exercise concluded. A series of recommendations was developed based on feedback from the players and controller/evaluators. These included improvements to the exercise scope and objectives, the problem-solving tasks, the scenarios, exercise control, the webcast sessions, the exercise website, and the player feedback process.

We update and extend the results of Shanks (1997, MNRAS, 290, L77) by making a direct test of Tully-Fisher distance estimates to thirteen spiral galaxies with HST Cepheid distances and to ten spiral galaxies with Type Ia supernova (SNIa) distances. The results show that the Tully-Fisher distance moduli are too short with respect to the Cepheid distances by 0.46+-0.11mag and too short with respect to the SNIa distances by 0.49+-0.18mag. Combining the HST Cepheid and the best SNIa data suggests that, overall, previous Tully-Fisher distances at v~1000 kms-1 were too short by 0.43+-0.09mag, a result which is significant at the 4.6 sigma level. These data therefore indicate that previous Tully-Fisher distances should be revised upwards by 22+-5% implying, for example, a Virgo distance of 19.0+-1.8Mpc. The value of Ho from Tully-Fisher estimates is correspondingly revised downwards from Ho=84+-10kms-1Mpc-1 to Ho=69+-8kms-1Mpc-1. There is evidence that the Tully-Fisher relation at large distances is affected by Malmquist bias. In this case, we argue that Ho<50kms-1Mpc-1 cannot be ruled out by Tully-Fisher considerations.

Atomic force microscopy using a magnetic tip is a promising tool for investigating conductivity on the nano-scale. By the oscillating magnetic tip eddy currents are induced in the conducting parts of the sample which can be detected in the phase signal of the cantilever. However, the origin of the phase signal is still controversial because theoretical calculations using a monopole appoximation for taking the electromagnetic forces acting on the tip into account yield an effect which is too small by more than two orders of magnitude. In order to determine the origin of the signal we used especially prepared gold nano patterns embedded in a non-conducting polycarbonate matrix and measured the distance dependence of the phase signal. Our data clearly shows that the interacting forces are long ranged and therefore, are likely due to the electromagnetic interaction between the magnetic tip and the conducting parts of the surface. Due to the long range character of the interaction a change in conductivity of $\\Del...

The early work of Lorentz, Abraham and others, evolved through the work of Fokker, Dirac and others to ultimately culminate in the Feynman- Wheeler direct action at a distance theory. However this theory has encountered certain conceptual difficulties like non-locality in time, self force of the electron, pre acceleration and the perfect absorption condition of Feynman and Wheeler, that is the instantaneous action of the remaining charges in the universe on the charge in question. More recently, Hoyle and Narlikar have resurrected this theory, but within the context of a Steady State or Quasi Steady State cosmology. They argue that the theory infact has a better standing than the generally accepted quantum theoretic description. In this article we consider a quantum theoretic description and a cosmology which parallels the Hoyle-Narlikar approach. This leads to a synthesis and justification of the Dirac and Feynman-Wheeler approaches, clarifying the conceptual problems in the process. We deduce a scenario with quantized space-time and a holistic cosmology, consistent with physical and astrophysical data. The non-locality is now seen to be meaningful within the minimum space-time intervals, as also the perfect absorption within the holistic description. Local realism, and the usual causal field theory are seen to have an underpinning of direct action. For example this is brought out by the virtual photons which mediate interactions in Quantum Electro Dynamics, and the emergence of the inverse square law in the above approach from a background Zero Point Field.

Impulsive radio bursts that are detectable across cosmological distances constitute extremely powerful probes of the ionized Inter-Galactic Medium (IGM), intergalactic magnetic fields, and the properties of space-time itself. Their dispersion measures (DMs) will enable us to detect the "missing" baryons in the low-redshift Universe and make the first measurements of the mean galaxy halo profile, a key parameter in models of galaxy formation and feedback. Impulsive bursts can be used as cosmic rulers at redshifts exceeding 2, and constrain the dark energy equation-of-state parameter, $w(z)$ at redshifts beyond those readily accessible by Type Ia SNe. Both of these goals are realisable with a sample of $\\sim 10^4$ fast radio bursts (FRBs) whose positions are localized to within one arcsecond, sufficient to obtain host galaxy redshifts via optical follow-up. It is also hypothesised that gravitational wave events may emit coherent emission at frequencies probed by SKA1-LOW, and the localization of such events at ...

We present a new distance estimation method for dust-continuum-identified molecular cloud clumps. Recent (sub-)millimeter Galactic plane surveys have cataloged tens of thousands of these objects, plausible precursors to stellar clusters, but detailed study of their physical properties requires robust distance determinations. We derive Bayesian distance probability density functions (DPDFs) for 770 objects from the Bolocam Galactic Plane Survey in the Galactic longitude range 7. Degree-Sign 5 {<=} l {<=} 65 Degree-Sign . The DPDF formalism is based on kinematic distances, and uses any number of external data sets to place prior distance probabilities to resolve the kinematic distance ambiguity (KDA) for objects in the inner Galaxy. We present here priors related to the mid-infrared absorption of dust in dense molecular regions and the distribution of molecular gas in the Galactic disk. By assuming a numerical model of Galactic mid-infrared emission and simple radiative transfer, we match the morphology of (sub-)millimeter thermal dust emission with mid-infrared absorption to compute a prior DPDF for distance discrimination. Selecting objects first from (sub-)millimeter source catalogs avoids a bias towards the darkest infrared dark clouds (IRDCs) and extends the range of heliocentric distance probed by mid-infrared extinction and includes lower-contrast sources. We derive well-constrained KDA resolutions for 618 molecular cloud clumps, with approximately 15% placed at or beyond the tangent distance. Objects with mid-infrared contrast sufficient to be cataloged as IRDCs are generally placed at the near kinematic distance. Distance comparisons with Galactic Ring Survey KDA resolutions yield a 92% agreement. A face-on view of the Milky Way using resolved distances reveals sections of the Sagittarius and Scutum-Centaurus Arms. This KDA-resolution method for large catalogs of sources through the combination of (sub-)millimeter and mid-infrared observations of molecular cloud clumps is generally applicable to other dust-continuum Galactic plane surveys.

Estimates of the distances over which reactor accident consequences might occur are important for development of siting criteria and for emergency response planning. This paper summarizes the results of a series of CRAC2 calculations performed to estimate these distances. Because of the current controversy concerning the magnitude of source terms for severe accidents, the impact of source term reductions upon distance estimates is also examined.

Two colloidal particles, driven around an optical vortex trap, have been recently shown to pair due to an interplay between hydrodynamic interactions and the curved path they are forced to follow. We demonstrate here, that this pairing interaction can be tuned experimentally, and study its effect on the collective excitations of many particles driven around such an optical trap. We find that even though the system is overdamped, hydrodynamic interactions due to driving give rise to non-decaying excitations with characteristic dispersion relations. The collective excitations of the colloidal ring reflect fluctuations of particle pairs rather than those of single particles.

Attempts to achieve ``top kill'' of actively flowing oil wells by insertion of dense drilling ``muds'', i.e., slurries of dense minerals, from above will fail if the Kelvin-Helmholtz instability in the gravity-driven counterflow produces turbulence that breaks up the denser fluid into small droplets. Here we estimate the droplet size to be sub-mm for fast flows and suggest the addition of a shear-thickening polymer to suppress turbulence. Laboratory experiments show a progression from droplet formation to complete turbulence suppression at the relevant high velocities, illustrating rich new physics accessible by using a shear-thickening liquid in gravity driven counter-streaming flows.

Dynamical localization prevents driven atomic systems from fast fragmentation by hampering the excitation process. We present numerical simulations within a collinear model of microwave-driven helium Rydberg atoms and prove that dynamical localization survives the impact of electron-electron interaction, even for doubly excited states in the presence of fast autoionization. We conclude that the effect of electron-electron repulsion on localization can be described by an appropriate rescaling of the atomic level density and of the external field with the strength of the interaction.

In plasmas in the National Spherical Torus Experiment (NSTX) [Ono et al., Nucl. Fusion 40 (2000) 557] heated with neutral beams, the beam ions typically excite Energetic Particle Modes (EPMs or fishbones), and Toroidal, Global or Compressional Alfvén Eigenmodes (TAE, GAE, CAE). These modes can redistribute the energetic beam ions, altering the beam driven current profile and the plasma heating profile, or they may affect electron thermal transport or cause losses of the beam ions. In this paper we present experimental results where these instabilities, driven by the super-thermal beam ions, are suppressed with the application of High Harmonic Fastmore »Wave heating.« less

In plasmas in the National Spherical Torus Experiment (NSTX) [Ono et al., Nucl. Fusion 40 (2000) 557] heated with neutral beams, the beam ions typically excite Energetic Particle Modes (EPMs or fishbones), and Toroidal, Global or Compressional Alfvén Eigenmodes (TAE, GAE, CAE). These modes can redistribute the energetic beam ions, altering the beam driven current profile and the plasma heating profile, or they may affect electron thermal transport or cause losses of the beam ions. In this paper we present experimental results where these instabilities, driven by the super-thermal beam ions, are suppressed with the application of High Harmonic Fast Wave heating.

Entanglement generation, single-photon detection, and frequency translation that preserves the polarization quantum state of the photons are essential technologies for long distance quantum communication protocols. This ...

protection of EHV cable lines. For a reliable operation of a ground distance relay, the ground loop impedance of the discontinuity and its effects on the ground distance relay protection have not been discussed in literature need to be protected by distance relays when the communication link is lost. In addition, distance

Highlights: •The oncogenic miR-17-5p is downregulated in non-metastatic hepatocellular carcinoma patients. •E2F-1 and c-MYC transcripts are upregulated in non-metastatic HCC patients. •miR-17-5p forced overexpression inhibited E2F-1 and c-MYC expression in HuH-7 cells. •miR-17-5p mimicking increased HuH-7 cell growth, proliferation, migration and colony formation. •miR-17-5p is responsible for HCC progression among the c-MYC/E2F-1/miR-17-5p triad members. -- Abstract: E2F-1, c-MYC, and miR-17-5p is a triad of two regulatory loops: a negative and a positive loop, where c-MYC induces the expression of E2F-1 that induces the expression of miR-17-5p which in turn reverses the expression of E2F-1 to close the loop. In this study, we investigated this triad for the first time in hepatocellular carcinoma (HCC), where miR-17-5p showed a significant down-regulation in 23 non-metastatic HCC biopsies compared to 10 healthy tissues; however, E2F-1 and c-MYC transcripts were markedly elevated. Forced over-expression of miR-17-5p in HuH-7 cells resulted in enhanced cell proliferation, growth, migration and clonogenicity with concomitant inhibition of E2F-1 and c-MYC transcripts expressions, while antagomirs of miR-17-5p reversed these events. In conclusion, this study revealed a unique pattern of expression for miR-17-5p in non-metastatic HCC patients in contrast to metastatic HCC patients. In addition we show that miR-17-5p is the key player among the triad that tumor growth and spread.

Dust inertia and background density driven dust drift shock waves are theoretically studied in a rotating planetary environment and are subsequently applied to the planetary rings where the collisional effects are pronounced. It has been found that the system under consideration admits significant shock formation if the collision frequency is of the order of or less than the rotational frequency of the Saturn's rings.

A Novel, Web-Driven Continuous Mining Simulator By Steven J. Schafrik and Michael Karmis Department geometry of operations as well as other constraints. This paper presents WebConSim, a newly developed, Web underground and open-pit mining operations. OBJECTIVES AND DESIGN OF THE NEW WEB- BASED SIMULATOR One

Signal conÂ¯ict in spider webs driven by predators and prey Todd A. Blackledge Department silk designs, stabilimenta, in the centre of their webs. Stabilimenta can be highly visible signals to predators, warning them of the presence of a noxious, sticky silk web. However, stabilimenta can also

Scalable enhancement of graphene oxide properties by thermally driven phase transformation Priyank,2,4 * and Jeffrey C. Grossman1 * Chemical functionalization of graphene is promising for a variety of next-generation technologies. Although graphene oxide (GO) is a versatile material in this direction, its use is limited

Importance Driven Rendering ­ Using Importance Information in the Rendering Process R. Schultz describes the concept of using importance in- formation in the rendering process. Doing so, we can adapt the rendering time and image quality to the requirements of a user. For that, we discuss two problems

Neuromelanin biosynthesis is driven by excess cytosolic catecholamines not accumulated by synaptic by increasing vesicular accumulation of neurotransmitter. The NM is in a stable complex with ferric iron, and NM synthesis thus results from excess cytosolic catecholamines not accumulated into synaptic vesicles

) Electromagnetically and Thermally Driven Flow Phenomena in Electroslag Welding A. H. DILAWARI, J for the Electroslag Welding Process. In the formulation, allowance has been made {or both etee- tromagnetic and b in the use of electroslag welding (ESW), particularly for the construction of thick walled pressure vessels

have been funded by SAP Research and Queensland University of Technology with the project "ModellingModel-Driven Process Configuration of Enterprise Systems* Alexander Dreiling, Michael Rosemann Queensland University of Technology Wil van der Aalst Eindhoven University of Technology Wasim Sadiq SAP

Model-driven Application Design for a Campus Calendar Network Allison Bloodworth ' websites, or by sending an email with event information to a calendar administrator. This situation Berkeley Calendar Network. Our team created a web-based calendar that can display multiple views of events

MAC-EYE: a Tendon Driven Fully Embedded Robot Eye Dario Biamino, Giorgio Cannata, Marco Maggiali the possibility of designing a robot eye with kinematics and actuation similar to those of the human eye. In particular, we tried to exploit the spherical shape of the eye and to study the feasibility of a tendon based

Execution Trace-Driven Automated Attack Signature Generation Susanta Nanda Symantec Research Labs In its most general form, an attack signature is a program that can correctly determine if an input network packet se- quence can successfully attack a protected network appli- cation. Filter rules used

PHOTOSYNTHESIS AND GLOBAL CHANGE CAN CLIMATE DRIVEN CHANGES IN PHOTOSYNTHESIS BE USED TO PREDICT in photosynthesis, and thus substrate supply, influence the rate of ecosystem respiration (Re). Further- more in photosynthesis might result in concomitant changes in both the rate, and temperature-sensitivity, of Re. Re

A systems-driven approach is used to discern tradeoffs between cost and efficiency improvements for various thin-film module technologies and designs. Prospects for reduced system cost via such strategies are enhanced as balance-of-systems costs decline, and some strategies are identified for greater research focus.

Neutrino-driven winds, which follow core-collapse supernova explosions, present a fascinating nuclear astrophysics problem that requires understanding advanced astrophysics simulations, the properties of matter and neutrino interactions under extreme conditions, the structure and reactions of exotic nuclei, and comparisons against forefront astronomical observations. The neutrino-driven wind has attracted vast attention over the last 20 years as it was suggested to be a candidate for the astrophysics site where half of the heavy elements are produced via the r-process. In this review, we summarize our present understanding of neutrino-driven winds from the dynamical and nucleosynthesis perspectives. Rapid progress has been made during recent years in understanding the wind with improved simulations and better micro physics. The current status of the fields is that hydrodynamical simulations do not reach the extreme conditions necessary for the r-process and the proton or neutron richness of the wind remains to be investigated in more detail. However, nucleosynthesis studies and observations point already to neutrino-driven winds to explain the origin of lighter heavy elements, such as Sr, Y, Zr.

Doppler Ultrasound Driven Biomechanical Model of the Brain for Intraoperative Brain of the target is essential to reduce mor- bidity during brain tumor removal interventions. Yet, image-guided neu- rosurgery faces an important issue for large skull openings where brain soft-tissues can exhibit large

, the paper also shows that a plain MDA approach (the one used in the OMG Deployment and Configuration interconnections of their interfaces. 1.1. MDA Model-Driven Architecture (MDA) [19] is the latest approach of OMG these systems, rather it is an approach to software development using models. According to MDA concepts, systems

or sums of a few such powers. We also ask that the roots of D(z) all lie inside the unit circleSTABLE POLYNOMIALS FROM TRUNCATIONS AND ARCHITECTURE-DRIVEN FILTER TRANSFORMATIONS Nigel Boston Abstract. An extension of a polynomial consists of the polynomial plus higher power terms. Given

A low temperature analysis of the boundary driven Kawasaki Process Christian Maes and Winny O'Kelly de Galway Instituut voor Theoretische Fysica, KU Leuven June 17, 2013 Abstract Low temperature configurations even though the particle current tends to zero as the temperature reaches zero. That is because

(Castor, Abbott, and Klein 1975) model for radiative driving by scattering in a ensemble of lines from driving, foÂ­ cussing first on the standard CAK formalism for steady, lineÂ­driven stellar winds, University of Delaware, Newark, DE 19716 Abstract. The high luminosity of massive stars can drive substantial

(Castor, Abbott, and Klein 1975) model for radiative driving by scattering in a ensemble of lines from driving, fo- cussing first on the standard CAK formalism for steady, line-driven stellar winds, University of Delaware, Newark, DE 19716 Abstract. The high luminosity of massive stars can drive substantial

Theory Mathematical Modeling of PDGF-Driven Glioblastoma Reveals Optimized Radiation Dosing is inevi- table and survival has improved minimally over the last 50 years. Recent studies have suggested from glioblastoma (GBM), the most common and malignant primary brain tumor, have very poor survival

for motion sensor driven gesture recognition systems utilizing cloud technology and the FI- WARE core for training, monitoring movements, rehabilitation actions as well as educating purposes. In this work we focus and a motion sensor API for transforming specific hand language and gestures into system commands. The system

Driven Architecture (MDA) initiative from the Object Management Group (OMG) is a well-known example of model-based development as framed by the Model Driven Architecture (MDA) [MDA2001]. The MDA advocates

Distance-Engineered Plasmon-Enhanced Light Harvesting in CdSe Quantum Dots Shengye Jin,,§, Erica De) is essential for the development of efficient QD-based solar energy conversion systems. In this study, plasmon as a function of interparticle (QD to Ag NP) distance. Up to 24-fold plasmonic enhancement of fluorescence from

1 A SOFTWARE TOOL FOR WEB-BASED DISTANCE LEARNING SYSTEMS DESIGN Dr. Kasim M. Al-Aubidy Computer an attempt to introduce a software tool for development of a web-based distance-learning course. The second's degree of understanding in each unit. It provides a powerful educational tool that can assist the learner

Transition Metal Dimer Internuclear Distances from Measured Force Constants Joseph L. Jules distances, have been extended to the transition metal dimers to test which one gives the most accurate fit's and Guggenheimer's for the transition metal dimers. Although Pauling's rule gives the best results, the remarkable

On Required Distances to Absorb Metering Delays C. Gwiggner, S. Nagaoka Electronic Navigation Research Institute Chofu, Tokyo Abstract We analyze the distance that is required to absorb metering delays are a common phenomenon [1]. The reason is that uncertainty factors, including competition for punctual

-distance-to-go estimate. Operators frequently have different costs and cost-to-go is not the same as search both the estimated cost-to-go, given by a heuristic evaluation function h, as well as the searchUsing Distance Estimates in Heuristic Search Jordan T. Thayer and Wheeler Ruml Department

was conducted through two experiments focusing on foraging distances and forager population sizes. The foraging distances experiment used circular grids in 5 m x 5 m plots to map the movement of marked G. tubiformans released from the center of the grid...

621 OPEN DISTANCE INTER-UNIVERSITY SYNERGIES BETWEEN EUROPE, AFRICA AND THE MIDDLE EAST (ODISEAME and Middle East) is a project related to the fifth sector of application of the EUMEDIS initiative (Euro AND GOALS OF THE PROJECT ODISEAME (Open Distance Inter-university Synergies between Europe, Africa

The Naval Postgraduate School (NPS), Niowave, Inc., and Boeing have recently demonstrated operation of the first superconducting RF electron gun based on a quarter wave resonator structure. In preliminary tests, this gun has produced 10 ps long bunches with charge in excess of 78 pC, and with beam energy up to 396 keV. Initial testing occurred at Niowave's Lansing, MI facility, but the gun and diagnostic beam line are planned for installation in California in the near future. The design of the diagnostic beam line is conducive to the addition of a Cerenkov radiator without interfering with other beam line operations. Design and simulations of a Cerenkov radiator, consisting of a dielectric lined waveguide will be presented. The dispersion relation for the structure is determined and the beam interaction is studied using numerical simulations. The characteristics of the microwave radiation produced in both the short and long bunch regimes will be presented.

We report the discovery and analysis of a very strong magnetic field in the rapidly rotating early B-type star HR 5907, based on observations obtained as part of the Magnetism in Massive Stars (MiMeS) project. We infer a rotation period of 0.508276 +0.000015/-0.000012 d from photometric and H{\\alpha} EW measurements, making this the shortest period, non-degenerate, magnetic massive star known to date. From the comparison of IUE UV and optical spectroscopy with LTE BRUCE/KYLIE models we find a solid-angle integrated, uniform black-body temperature of 17 000 \\pm 1000 K, a projected rotational velocity of 290 \\pm 10 km/s, an equatorial radius of 3.1 \\pm 0.2 R_sun, a stellar mass of 5.5 \\pm 0.5 M_sun, and an inclination angle of the rotation axis to our line-of-sight of 70 \\pm 10\\circ. Our measurements of the longitudinal magnetic field, which vary between -500 and -2000 G, phase coherently with the rotation period and imply a surface dipole field strength of \\sim15.7 kG. On the other hand, from fits to mean Leas...

Cepheid-based distances to seven Type Ia supernovae (SNe)-host galaxies have been derived using the standard HST Key Project on the Extragalactic Distance Scale pipeline. For the first time, this allows for a transparent comparison of data accumulated as part of three different HST projects, the Key Project, the Sandage et al. Type Ia SNe program, and the Tanvir et al. Leo I Group study. Re-analyzing the Tanvir et al. galaxy and six Sandage et al. galaxies we find a mean (weighted) offset in true distance moduli of 0.12+/-0.07 mag -- i.e., 6% in linear distance -- in the sense of reducing the distance scale, or increasing H0. Adopting the reddening-corrected Hubble relations of Suntzeff et al. (1999), tied to a zero point based upon SNe~1990N, 1981B, 1998bu, 1989B, 1972E and 1960F and the photometric calibration of Hill et al. (1998), leads to a Hubble constant of H0=68+/-2(random)+/-5(systematic) km/s/Mpc. Adopting the Kennicutt et al. (1998) Cepheid period-luminosity-metallicity dependency decreases the inferred H0 by 4%. The H0 result from Type Ia SNe is now in good agreement, to within their respective uncertainties, with that from the Tully-Fisher and surface brightness fluctuation relations.

Linear and nonlinear analysis of coupled drift and acoustic mode is presented in an inhomogeneous electron-ion plasma with {kappa}-distributed electrons. A linear dispersion relation is found which shows that the phase speed of both the drift wave and the ion acoustic wave decreases in the presence of superthermal electrons. Several limiting cases are also discussed. In the nonlinear regime, stationary solutions in the form of dipolar and monopolar vortices are obtained. It is shown that the condition for the boundedness of the solution implies that the speed of drift wave driven vortices reduces with increase in superthermality effect. Ignoring density inhomogeniety, it is investigated that the lower and upper limits on the speed of the ion acoustic driven vortices spread with the inclusion of high energy electrons. The importance of results with reference to space plasmas is also pointed out.

Accelerating parameters of beam-driven wakefield acceleration in an extremely dense plasma column has been analyzed with the dynamic framed particle-in-cell plasma simulator, and compared with analytic calculations. In the model, a witness beam undergoes a TeV/m scale alternating potential gradient excited by a micro-bunched drive beam in a 1025 m-3 and 1.6 x 1028 m-3 plasma column. The acceleration gradient, energy gain, and transformer ratio have been extensively studied in quasi-linear, linear-, and blowout-regimes. The simulation analysis indicated that in the beam-driven acceleration system a hollow plasma channel offers 20 % higher acceleration gradient by enlarging the channel radius (r) from 0.2 Ap to 0.6 .Ap in a blowout regime. This paper suggests a feasibility of TeV/m scale acceleration with a hollow crystalline structure (e.g. nanotubes) of high electron plasma density.

Accelerating parameters of beam-driven wakefield acceleration in an extremely dense plasma column has been analyzed with the dynamic framed particle-in-cell plasma simulator, and compared with analytic calculations. In the model, a witness beam undergoes a TeV/m scale alternating potential gradient excited by a micro-bunched drive beam in a 1025 m-3 and 1.6 x 1028 m-3 plasma column. The acceleration gradient, energy gain, and transformer ratio have been extensively studied in quasi-linear, linear-, and blowout-regimes. The simulation analysis indicated that in the beam-driven acceleration system a hollow plasma channel offers 20 % higher acceleration gradient by enlarging the channel radius (r) from 0.2 ?p to 0.6 ?p in a blowout regime. This paper suggests a feasibility of TeV/m scale acceleration with a hollow crystalline structure (e.g. nanotubes) of high electron plasma density.

We propose a stochastic process wherein molecular transport is mediated by asymmetric nucleation of domains on a one-dimensional substrate. Track-driven mechanisms of molecular transport arise in biophysical applications such as Holliday junction positioning and collagenase processivity. In contrast to molecular motors that hydrolyze nucleotide triphosphates and undergo a local molecular conformational change, we show that asymmetric nucleation of hydrolysis waves on a track can also result in directed motion of an attached particle. Asymmetrically cooperative kinetics between ``hydrolyzed'' and ``unhydrolyzed'' states on each lattice site generate moving domain walls that push a particle sitting on the track. We use a novel fluctuating-frame, finite-segment mean field theory to accurately compute steady-state velocities of the driven particle and to discover parameter regimes which yield maximal domain wall flux, leading to optimal particle drift.

Accelerating parameters of beam-driven wakefield acceleration in an extremely dense plasma column has been analyzed with the dynamic framed particle-in-cell plasma simulator, and compared with analytic calculations. In the model, a witness beam undergoes a TeV/m scale alternating potential gradient excited by a micro-bunched drive beam in a 1025 m-3 and 1.6 x 1028 m-3 plasma column. The acceleration gradient, energy gain, and transformer ratio have been extensively studied in quasi-linear, linear-, and blowout-regimes. The simulation analysis indicated that in the beam-driven acceleration system a hollow plasma channel offers 20 % higher acceleration gradient by enlarging the channel radius (r)more »from 0.2 ?p to 0.6 ?p in a blowout regime. This paper suggests a feasibility of TeV/m scale acceleration with a hollow crystalline structure (e.g. nanotubes) of high electron plasma density.« less

Dumbbell micro-robot driven by flow oscillations By V. A. V l a d i m i r o v Dept of Mathematics-propulsion of a dumbbell micro-robot submerged in a viscous fluid. The micro-robot consists of two rigid spherical beads of each sphere differs from the density of a fluid, while the whole micro-robot has neutral buoyancy

Supersonic rotation in mirrors may be produced by radio frequency waves. The waves produce coupled diffusion in ion kinetic and potential energy. A population inversion along the diffusion path then produces rotation. Waves may be designed to exploit a natural kinetic energy source or may provide the rotation energy on their own. Centrifugal traps for fusion and isotope separation may benefit from this wave-driven rotation.

Executive Summary A FAculty-Driven PlAn SePtember 2009 reSeArch uF/iFAS roADmAP #12;UF/IFAS ReSeARch RoAdmAp Executive Summary 2 It is easier to plan when resources are plentiful, but it is far more. With these realities in mind, we began the process of developing a Research Roadmap. It was purposely designed

Laser-direct-driven ramp compression experiments were performed on long temporally shaped laser pulses based on an analytical isentropic compression model. Upper pressure limits, the ablation pressure scaling law, and stress-density curves were studied. The validity of the analytical model used, the ablation pressure scaling law, and the phenomena of missing line-imaging velocity interferometer (VISAR) fringes in the experimental results are discussed.

Absorption cycle refrigeration processes and systems are provided which are driven by the sensible waste heat available from industrial processes and other sources. Systems are disclosed which provide a chilled water output which can be used for comfort conditioning or the like which utilize heat from sensible waste heat sources at temperatures of less than 170.degree. F. Countercurrent flow equipment is also provided to increase the efficiency of the systems and increase the utilization of available heat.

The most recent cosmological observations indicate that the present universe is flat and vacuum dominated. In such a universe, the distance measurements are always difficult and involve numerical computations. In this paper, it is shown that the most fundamental distance measurement of cosmology, the luminosity distance, for such a universe can be obtained in an approximate analytical way with very small errors of less than 0.02% up to %z = 5$ for any value of vacuum energy. The analytical calculation is shown to be exceedingly efficient, as compared to the traditional numerical methods.

Dynamical chaos has previously been observed experimentally in a driven dusty plasma with three particles [T. E. Sheridan, Phys. Plasmas 12, 080701 (2005)]. In the present work, the transition to chaos in this system is studied as a function of the amplitude of a periodic driving force for two different driving frequencies f{sub d}. It is found that the system follows a quasiperiodic route to chaos. The dusty plasma's center-of-mass modes are driven by the first harmonic of f{sub d} and lock to the driving force for small driving amplitudes. The breathing mode is driven by the second harmonic of f{sub d} and shows asymmetric spectral features indicating quasiperiodic dynamics for intermediate driving amplitudes. For large driving forces both the center-of-mass and breathing modes are entrained and a region of low-dimensional chaotic dynamics due to a resonance overlap is observed. In the chaotic regime the correlation dimension and Lyapunov exponent are found to increase with the driving force.

This thesis explains the origins of neutrinos and their interactions, and the phenomenon of neutrino oscillations. Experiments for measuring neutrino oscillations are mentioned and the experiment investigated in this thesis, the ''Main Injector Neutrino Oscillation Search'', and its neutrino beam, the Fermi National Accelerator Laboratory's ''Neutrinos At The Main Injector'', are described. MINOS is a long baseline (735 km) neutrino oscillation experiment with a near and a far detector, intended to make precision measurements of the atmospheric sector neutrino oscillation parameters. A measurement is made of the ''atmospheric'' neutrino oscillation parameters, {Delta}m{sub 23}{sup 2} and sin {sup 2}(2{theta}{sub 23}), using neutrinos from the NuMI beam. The results of this analysis are compared to measurements at MINOS using neutrinos from the atmosphere and with other experiments. A more detailed method of beam neutrino analysis is discussed, and the extra calibrations needed to perform that analysis properly are described, with special attention paid to two aspects of the calibration, which comprise the bulk of work for this thesis. The light injection calibration system uses LEDs to illuminate the detector readout and provides a normalization of the stability of the detector over time. The hardware and different modi operandi of the system are described. There is a description of installation and commissioning of the system at one of the MINOS detectors. The response normalization of each detector with cosmic ray muons is described. Special attention is paid to the explanation of necessary corrections that must be made to the muon sample in order for the sample to be used to calibrate each detector to the specified accuracy. The performance of the calibration is shown.

The goal of this project was to develop and execute a novel drilling and completion program in the Antrim Shale near the western shoreline of Northern Michigan. The target was the gas in the Lower Antrim Formation (Upper Devonian). Another goal was to see if drilling permits could be obtained from the Michigan DNR that would allow exploitation of reserves currently off-limits to exploration. This project met both of these goals: the DNR (Michigan Department of Natural Resources) issued permits that allow drilling the shallow subsurface for exploration and production. This project obtained drilling permits for the original demonstration well AG-A-MING 4-12 HD (API: 21-009-58153-0000) and AG-A-MING 4-12 HD1 (API: 21-009-58153-0100) as well as for similar Antrim wells in Benzie County, MI, the Colfax 3-28 HD and nearby Colfax 2-28 HD which were substituted for the AG-A-MING well. This project also developed successful techniques and strategies for producing the shallow gas. In addition to the project demonstration well over 20 wells have been drilled to date into the shallow Antrim as a result of this project's findings. Further, fracture stimulation has proven to be a vital step in improving the deliverability of wells to deem them commercial. Our initial plan was very simple; the 'J-well' design. We proposed to drill a vertical or slant well 30.48 meters (100 feet) below the glacial drift, set required casing, then angle back up to tap the resource lying between the base to the drift and the conventional vertical well. The 'J'-well design was tested at Mancelona Township in Antrim County in February of 2007 with the St. Mancelona 2-12 HD 3.

show that by representing the geometry with a signed distance function (SDF), the camera pose can be efficiently estimated by directly minimizing the error of the depth images on the SDF. As the SDF contains

The purpose of this study was to develop an instrument for assessing distance learning readiness of institutions in Latin America for international projects of food and agriculture with higher education institutions in the ...

reflect the driver and vehicle population currently on the transportation network. An accident causation study was conducted to determine if roadways with limited stopping sight distance present a safety hazard for the transportation network. Rural two...

Mary Favret’s War at a Distance: Romanticism and the Making of Modern Wartime is a brilliant, beautifully written book on the experience of war in British Romantic writing. Offering intricate close readings of Cowper, ...

This thesis studies distance approximation in two closely related models - the streaming model and the two-party communication model. In the streaming model, a massive data stream is presented in an arbitrary order to a ...

-scale distance, can help to further scale data-movement capabilities in high performance computing (HPC demands within high performance computing (HPC) systems. Silicon photonic (SiP) interconnects [1-3], which

A 3-DIMENSIONAL ANALYSIS OF SIGHT DISTANCE ON INTERCHANGE RAMPS AND CONNECTORS A Thesis by EDDIE SANCHEZ Submitted to the Office of Graduate Studies of Texas A&M University in partial fulfdlment of the requiretnents for the degree of MASTER... OF SCIENCE August 1992 Major Subject: Civil Engineering A 3-DIMENSIONAL ANALYSIS OF SIGHT DISTANCE ON INTERCHANGE RAMPS AND CONNECTORS A Thesis by EDDIE SANCHEZ Approved as to style and content by: Raymond A. Krammes (Chair of Committee) N ' n J...

We report on the discovery of Cepheids in the field spiral galaxy NGC 3621, based on observations made with the Wide Field and Planetary Camera 2 on board the Hubble Space Telescope (HST). NGC 3621 is one of 18 galaxies observed as a part of The HST Key Project on the Extragalactic Distance Scale, which aims to measure the Hubble constant to 10% accuracy. Sixty-nine Cepheids with periods in the range 9--60 days were observed over 12 epochs using the F555W filter, and 4 epochs using the F814W filter. The HST F555W and F814W data were transformed to the Johnson V and Kron-Cousins I magnitude systems, respectively. Photometry was performed using two independent packages, DAOPHOT II/ALLFRAME and DoPHOT. Period-luminosity relations in the V and I bands were constructed using 36 fairly isolated Cepheids present in our set of 69 variables. Extinction-corrected distance moduli relative to the LMC of 10.63 +/- 0.07 mag and 10.56 +/- 0.10 mag were obtained using the ALLFRAME and DoPHOT data, respectively. True distance moduli of 29.13 +/- 0.18 mag and 29.06 +/- 0.18 mag, corresponding to distances of 6.3 Mpc and 6.1 Mpc, were obtained by assuming values of 18.50 +/- 0.10 mag for the distance modulus of the LMC and E(V-I) = 0.13 mag for the reddening of the LMC.

We present an empirical method that uses multicolor light curve shapes (MLCS) to estimate the luminosity, distance, and total line-of-sight extinction of Type Ia supernovae (SN Ia). The empirical correlation between the MLCS and the luminosity is derived from a ``training set'' of nine SN Ia light curves with independent distance and reddening estimates. We find that intrinsically dim SN Ia are redder and have faster light curves than the bright ones which are slow and blue. By thirty-five days after maximum the intrinsic color variations become negligable. A formal treatment of extinction employing Bayes' theorem is used to estimate the best value and its uncertainty. Applying MLCS to both light curves and to color curves provides enough information to determine which supernovae are dim because they are distant, which are intrinsically dim, and which are dim because of extinction by dust. The precision of the MLCS distances is examined by constructing a Hubble diagram with an independent set of twenty SN Ia's. The dispersion of 0.12 mag indicates a typical distance accuracy of 5 % for a single object, and the intercept yields a Hubble constant on the Cepheid distance scale (Sandage et al 1994, 1996) of H_0=65 \\pm 3 (statistical) km/s/Mpc ( \\pm 6 total error). The slope of 0.2010 pm 0.0035 mag over the distance interval 32.2 < mu < 38.3 yields the most precise confirmation of the linearity of the Hubble law.

to reduce the access of solar wind ions to the inner magnetosphere, which, through the MI coupling in LFM in the magnetosphere, the solar wind and the iono- sphere. Shelley et al. [1972] were the first to reveal been suggested that resonant energization by broadband lowfrequency waves is the most important mech

We present new ATCA 17- and 24-GHz radio images and ESO-NTT optical spectra of the radio-loud Seyfert galaxy IC5063, the first galaxy in which a fast (~ 600 km/s) outflow of neutral hydrogen was discovered. The new radio data confirm the triple radio structure with a central core and two resolved radio lobes. This implies that the previously detected fast outflow of neutral gas is occurring off-nucleus, near a radio lobe about 0.5 kpc from the core. The ionised gas shows complex kinematics in the region co-spatial with the radio emission. Broad and blueshifted (~ 500 km/s) emission is observed in the region of the radio lobe, at the same location as the blueshifted HI absorption. The velocity of the ionised outflow is similar to the one found in HI. The first order correspondence between the radio and optical properties suggests that the outflow is driven by the interaction between the radio jet and the ISM. Despite the high outflow velocities, no evidence is found for the ionisation of the gas being due to fast shocks in the region of the outflow, indicating that photoionisation from the AGN is likely to be the dominant ionisation mechanism. The outflow rate of the warm (ionised) gas is small compared to that of the cold gas. The mass outflow rate associated with the HI is in the same range as for ``mild'' starburst-driven superwinds in ULIRGs. However, in IC5063, the AGN-driven outflow appears to be limited to the inner kpc region of the galaxy. The kinetic power associated with the HI outflow is a small fraction (a few x 10^-4) of the Eddington luminosity of the galaxy but is a significant fraction (~ 0.1) of the nuclear bolometric luminosity. In IC5063, the outflows may have sufficient kinetic power to have a significant impact on the evolution of the ISM in the host galaxy.

A GRMHD model of disk outflows with neutrino-driven mass ejection is presented. The model is used to calculate the structure of the outflow in the sub-slow magnetosonic region and the mass loading of the outflow, under conditions anticipated in the central engines of gamma-ray bursts. It is concluded that magnetic launching of ultra-relativistic polar outflows is in principle possible along low inclination field lines (with respect to the symmetry axis), provided the neutrino luminosity is sufficiently low, $L_\

The spontaneous emergence of dynamical order, such as persistent currents, is sometimes argued to require principles beyond the entropy maximization of the second law of thermodynamics. I show that, for linear dissipation in the Onsager regime, current formation can be driven by exactly the Jaynesian principle of entropy maximization, suitably formulated for extended systems and nonequilibrium boundary conditions. The Legendre dual structure of equilibrium thermodynamics is also preserved, though it requires the admission of current-valued state variables, and their correct incorporation in the entropy.

We explore the quantum dynamics of particles in a spatiotemporally driven lattice. A powerful numerical scheme is developed, which provides us with the Floquet modes and thus enables a stroboscopic propagation of arbitrary initial states. A detailed symmetry analysis represents the cornerstone for an intricate manipulation of the Floquet spectrum. Specifically, we show how exact crossings can be converted into avoided ones, while the width of these resulting avoided crossings can be engineered by adjusting parameters of the local driving. Asymptotic currents are shown to be controllable over a certain parameter range.

Free energy signatures related to the measurement of an emergent force (?10{sup ?9}N) due to the exciton condensate (EC) in Double Quantum Wells are predicted and experiments are proposed to measure the effects. The EC-force is attractive and reminiscent of the Casimir force between two perfect metallic plates, but also distinctively different from it by its driving mechanism and dependence on the parameters of the condensate. The proposed experiments are based on a recent experimental work on a driven micromechanical oscillator. Conclusive observations of EC in recent experiments also provide a strong promise for the observation of the EC-force.

We study experimentally and numerically the dynamics of colloidal beads confined by a harmonic potential in a bath of swimming E. coli bacteria. The resulting dynamics is well approximated by a Langevin equation for an overdamped oscillator driven by the combination of a white thermal noise and an exponentially correlated active noise. This scenario leads to a simple generalization of the equipartition theorem resulting in the coexistence of two different effective temperatures that govern dynamics along the flat and the curved directions in the potential landscape.

In this proceeding, an idea is outlined suggesting a generic treatment on any type of input data for a numerical analytic continuation problem, which is needed when dynamical information is to be extracted from a calculationally convenient one particle imaginary time Green function. The quality of the resulting spectral function will rely only on the data to be treated, viz, data-driven. This is different from the Maximum Entropy or the Stochastic method which relies on an entropy term to guide convergence of the resulting spectral function.