GeneCards Summary for MLANA Gene

UniProtKB/Swiss-Prot for MLANA Gene

Involved in melanosome biogenesis by ensuring the stability of GPR143. Plays a vital role in the expression, stability, trafficking, and processing of melanocyte protein PMEL, which is critical to the formation of stage II melanosomes.

Graphical View of Domain Structure for InterPro Entry

No data available for
Gene Families and
UniProtKB/Swiss-Prot
for MLANA Gene

Function for MLANA Gene

Molecular function for MLANA Gene

UniProtKB/Swiss-Prot Function: Involved in melanosome biogenesis by ensuring the stability of GPR143. Plays a vital role in the expression, stability, trafficking, and processing of melanocyte protein PMEL, which is critical to the formation of stage II melanosomes.

Flow Cytometry Products

Localization for MLANA Gene

Subcellular locations from UniProtKB/Swiss-Prot for MLANA Gene

Endoplasmic reticulum membrane; Single-pass type III membrane protein. Golgi apparatus. Golgi apparatus, trans-Golgi network membrane. Melanosome. Note=Also found in small vesicles and tubules dispersed over the entire cytoplasm. A small fraction of the protein is inserted into the membrane in an inverted orientation. Inversion of membrane topology results in the relocalization of the protein from a predominant Golgi/post-Golgi area to the endoplasmic reticulum. Melanoma cells expressing the protein with an inverted membrane topology are more effectively recognized by specific cytolytic T-lymphocytes than those expressing the protein in its native membrane orientation.