Iupati (triceps) has been ruled out for Sunday's matchup against the Niners by head coach Bruce Arians, as he is expected to undergo surgery on his elbow to repair a bone spur, Josh Weinfuss of ESPN reports.

Iupati is still recovering from an ankle injury he sustained in 2013, but he remains confident that he will be ready for the start of the season. When he does return from injury, he should continue to be one of the best run blockers in the NFL.

2013

Iupati will reprise his role as the 49ers starting left guard and will continue to be a primary blocker for one of the league's top rushing attacks.

2011

Iupati will start at left guard.

2010

One of the 49ers' two first-round offensive lineman draft picks, Iupati will battle with veteran David Baas for the starting job at left guard, and Iupati is expected to win that battle.