By providing minimal energy reduction the new DMV-Bio Cell design ensures that sufficient optical energy is available to measure low volume samples accurately across a wide absorbance range. This is an important benefit to scientists who require accuracy and precision.

Incorporating this simple optical transmission path allows the DMV-Bio Cell to be used in most UV-Visible spectrophotometers without compromise for the determination of nucleic acids or proteins.

The Starna DMV-Bio Cell utilises a magnetic closure mechanism which facilitates rapid filling/emptying plus easy cleaning of the cell, to prevent carryover and for ultimate convenience.

Available in 0.5, 0.2 and 0.125 mm path lengths, the accuracy of the DMV-Bio Cell may be validated using a specially formulated variant of the Starna Green Certified Reference Material (CRM). In addition, for technicians working with DNA materials and who require confidence in their analysis, Starna offer the DNACON 260/280 CRM which is formulated to match the capabilities of the DMV-Bio Cell.

The new Starna DMV-Bio Cell with its range of path lengths provides accurate and reproducible measurements on existing spectrophotometers, using sample volumes down to 0.6 µl across a wide range of concentrations.

The new product exhibits extremely high electroporation efficiencies that approach the theoretical maximum of 3.4 x 1011 cfu/µg pUC19 DNA. Transferring exogenous DNA into E. coli is a standard laboratory method for cloning genes and constructing cDNA, genomic and epitope libraries. The limiting factor in many library-screening efforts or multiple fragment ligations is the efficiency by which DNA can be introduced into E. coli. Electroporation is one method to efficiently introduce DNA into E. coli. CloneCatcher™ Gold cells meet the needs of scientists that are seeking to find rare clones or are building complex or metagenomic libraries. CloneCatcher™ Gold significantly outperforms all other commercially available Electrocompetent Cells when introducing ligated DNA. When the amount of input DNA is limited, CloneCatcher Gold enhances your likelihood of success. CloneCatcher™ Gold requires less topoisomerase-loaded vector and therefore can reduce your overall operating costs. Supplied in convenient single-use tubes - CloneCatcher™ Gold can also enhance your productivity as the whole protocol for use takes only 10 minutes.

For further information on CloneCatcher™ Gold please visit our Website.

At this year’s Achema, Eppendorf and the DASGIP Information and Process Technology GmbH presented for the first time the new DASbox single-use vessel for parallel bioprocessing.

Eppendorf/DASGIP

The development of the DASbox single-use vessel reinforces the strong synergy that benefits both DASGIP and the Eppendorf AG, which acquired the bioprocessing specialist this past January. “Within a very short time we were able to combine the long-standing competency of the Eppendorf AG in the field of plastics technology with our bioreactor expertise, which led to a new product”, explains Dr. Matthias Arnold, member of DASGIP management and head of the development department.

The DASbox single-use vessel is the first single-use bioreactor which was developed for the DASGIP Parallel Bioreactor Systems. As a fully instrumented mini bioreactor with a working volume of 60-250 ml, it was constructed specifically for use in combination with the DASGIP DASbox mini bioreactor system. Especially with cell culture users in mind, the advantages of single-use technology are combined with the benefits of parallel cultivation and the full functionality of industrial bioreactors. All critical process parameters such as pH, soluble oxygen and optical density can be monitored and controlled using industry standard probes.

Integrated dip tubes allow for controlled addition of liquids, sampling, as well as fully massflow controlled gas supply. The magnet coupled stirrer is only one of the examples for the uncompromising sterile technology of this single-use bioreactor. A special feature of the DASbox single-use vessel is the novel, liquid-free Peltier element temperature control and condensation. This innovation, which enables, amongst others, efficient liquid condensation from the exhaust air, represents a further milestone in the transfer of the requirements of classic bioreactor technology to single-use technology.

The DASbox single-use vessel accelerates bioprocess development. The small working volumes save precious cell material and media, and extensive cleaning and sterilization procedures are superfluous. Less time is required for installation of the bioreactor, and cross contaminations are virtually excluded. Parallel cultivation under precisely controlled conditions delivers reliable results, fast. Further, the comprehensive software functions of DASGIP DASware allow user friendly and detailed capture, saving, analysis and management of resulting data.

Total RNA from multiple species – including mammalian, plant and yeast samples – has been validated using the automated process. The scalable, high throughput service allows processing from one to hundreds of samples without compromising quality.

“Automated processing of RNA-Seq using the Biomek platform provides high quality data, and accommodates projects from small to large,” said Bernhard Spiess, vice president of sales and marketing, Beckman Coulter Genomics. “We are very pleased with this enhanced service and the ability to provide scientists with reliable, reproducible results in a timely manner.”

Technical experts in the company’s genomics services group utilize extensive experience to provide highly reliable data. Typical turnaround time is four to seven weeks after sample receipt. For more information about this service, please visit www.beckmangenomics.com/rna-seq

Sartorius Stedim Biotech presents the new system FlexAct® that enables you to custom- configure single-use solutions for entire biomanufacturing steps.

Sartorius Stedim Biotech

FlexAct® is a new system that enables you to custom- configure single-use solutions for entire biomanufacturing steps. The FlexAct® system consists of the central opera- ting module that offers the widest variety of configuration options so you can take complete control of practically any steps in upstream and downstream processing.

The core of FlexAct®, the central operating module (COM), has been designed to be used in any application. This means you can quickly reconfigure FlexAct® in just a few easy steps. For example, take the FlexAct® BP for buffer preparation and effortlessly convert it into FlexAct® VR for virus removal.

And it goes without saying that the technologies and products used in FlexAct® are scalable. This makes FlexAct® a future-proof system in every respect; one that gives you the greatest possible flexibility.

Growing importance of fields like stem cell research require cytokines and growth factors produced in a safe host organism that prevent the occurrence of unwanted cellular responses caused by high endotoxin levels and other bacterial or mammalian impurities. Many commercially available cytokines and growth factors have endotoxin levels and other impurities high enough to seriously affect cellular processes like proliferation or differentiation.

PromoKine’s plant-derived cytokines and growth factors are free of animal components, serum traces, and antibiotics. They are also free of human, animal or bacterial infectious agents and have an endotoxin content typically 20-times lower than proteins produced in E. coli. Thus, they avoid problems caused by too high endotoxin levels and improve critical applications, e.g. in stem cell research.

ForteBio announced the launch of the Octet® HTX system, the new flagship member of the Octet line of label-free interaction analysis systems.

ForteBio - a division of Pall Life Sciences

ForteBio, a division of Pall Life Sciences and a leading supplier of instrumentation for accelerated drug discovery and development, today announced the launch of the Octet® HTX system, the new flagship member of the Octet line of label-free interaction analysis systems. The Octet HTX system addresses the acute industry need for increased analysis speed and sample throughput when characterizing large numbers of therapeutic candidates.

Octet systems provide unique insights into drug-target binding interactions, insights that are used to fine-tune the affinity and specificity of drug molecules. The Octet HTX instrument performs kinetic analysis of up to 96 binding interactions simultaneously, a capability offered by no other stand-alone label-free platform. The system offers dramatic time savings for researchers studying large panels of drug candidates, and provides innovative data analysis tools for developers of monoclonal antibodies and other biotherapeutic entities. In addition, the Octet HTX performs full 96-well plate determinations of protein concentrations in as little as 2 minutes.

“The need for higher analytical throughput is a central theme with our pharmaceutical and biopharm customers,” noted Robert Wicke, General Manager at Pall’s ForteBio Division. “We believe researchers will be delighted by the Octet HTX system. The HTX system was engineered for speed while maintaining peak performance, and will directly address critical bottlenecks in the drug development process.”

The Octet HTX system was unveiled today at the BioProcess International 2013 conference in Boston, Mass.

The ProdX software provides seamless integration of product inspection devices making processes more streamlined, more accessible and more efficient.

Mettler Toledo

Seamless Integration of Product Inspection Devices

Whatever your role in product inspection management, you will have plenty of challenges to face in marketplaces that increasingly demand more for less.

ProdX Inspect data management software provides seamless integration of product inspection devices making processes more streamlined, more accessible and more efficient. ProdX allows you to control your entire product inspection management process from a single point or from multiple remote locations, eliminating the need for time-consuming production line patrols.

ProdX Savings Calculator

Calculate your time savings potential with ProdX

This Calculator runs through all costs involved in the setup and data collection processes. It calculates the amount you could save per year by comparing the time requirement of manual processes and the automated data collection process this software offers.

ProdX Quality Management & AssuranceThe innovative ProdX software automatically collects the critical inspection process data you need in one convenient location significantly reducing the need to interact directly with the Critical Control Points on your factory floor. This saves time and effort enabling quality operatives to focus on other issues.

ProdX Production Process Managment

ProdX allows you to control your entire product inspection management process from a single point or from multiple remote locations, eliminating the need for time-consuming production line patrols.

PromoKine is now adding more than 200 new ELISA kits for target molecules which play integral roles in cell signaling research.

PromoCell GmbH

PromoKine currently offers ~400 ELISA kits for detecting and quantifying the "free" forms of human, mouse, rat, monkey and pig cytokines, growth factors and other cell biology target molecules in cell culture supernatants, plasma, serum and other body fluids. Some can even be used with tissue lysates! Our ready-to-use ELISA kits are very convenient, including a user-friendly and easy-to-follow protocol along with all the necessary components to perform a highly sensitive, reliable and reproducible ELISA.

PromoKine is now adding more than 200 new ELISA kits for target molecules which play integral roles in cell signaling research; such as diverse interleukins, FGFs, CD markers, BMPs, MIPs, MMPs and MCPs as well as Activin A, beta-NGF, Cardiotrophin, Lymphotactin, Oncostatin M, Insulin and several other hormones. We also have launched a new line of Cell-based Phosphorylation ELISAs.

Along with this, we are extending our comprehensive product line of recombinant cytokines, growth factors, soluble receptors, hormones and other proteins/peptides involved in cell signaling as well as our wide range of antibodies against these molecules.

The Biometra GmbH, a company of the Analytik Jena AG, now offers illuminators with high-performance blue light LEDs for gel documentation purposes.

Biometra

Blue light transilluminators are a quite interesting alternative to UV tables as there is no risk of sample damage during illumination. This is important when samples shall be processed furthermore after gel documentation. Users also benefit from it as there is no risk of UV exposure. Blue light excitation is applicable for fluorescent dyes for nucleic acid or protein stains with excitation wavelength around 470 nm. Examples for compatible stains are: SYBR® Green, GelGreenTM, SYBR® Safe, SYBR® Gold or SYPRO® Ruby. The amber lid of the instrument allows the direct view to the fluorescent samples. There is no need for separate glasses. The new blue light illuminators are available in two versions: "BLstar 9", the handy solution for mini gels and "BLstar 16" for gels up to size of 16 cm x 20 cm.

Thermo Fisher Scientific releases new small benchtop centrifuge, which provides scientists with outstanding capacity in a compact design.

Thermo Fisher Scientific

Thermo Fisher Scientific Inc. has launched a new small benchtop centrifuge to meet clinical and research needs alike.

“Centrifuges are in constant use and demand so preventing downtime and bottlenecks is crucial,” said Maurizio Merli, product director, Thermo Fisher Scientific. “With features designed for simplicity, safety and flexibility, the new small benchtop centrifuges can help scientists save time and maximize resources.”

Partner-Events

Stockholm (SE)

Wien (A)

Product of the week

BioShake Series

The BioShake series contains high-speed mixer and thermal mixer for small and very small volumes in microplates and reaction tubes and allows for the first time high precise and efficient mixing in the microliter scale for a wide range of applications. more