This product is an active protein and may elicit a biological response in vivo, handle with caution.

常规信息

别名

c Jun kinase 2

C Jun N terminal kinase 2

c-Jun N-terminal kinase 2

JNK 55

JNK-55

JNK2

JNK2 alpha

JNK2 beta

JNK2A

JNK2alpha

JNK2B

JNK2BETA

Jun kinase

MAP kinase 9

MAPK 9

Mapk9

Mitogen activated protein kinase 9

Mitogen-activated protein kinase 9

MK09_HUMAN

P54a

p54aSAPK

PRKM9

SAPK

SAPK alpha

SAPK1a

Stress activated protein kinase 1a

Stress-activated protein kinase JNK2

see all

功能Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as c-Jun and ATF2 and thus regulates AP-1 transcriptional activity. In T-cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells.JNK2 isoforms display different binding patterns: alpha-1 and alpha-2 preferentially bind to c-Jun, whereas beta-1 and beta-2 bind to ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms. JUNB is not a substrate for JNK2 alpha-2, and JUND binds only weakly to it.

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The tag used in this preparation is GST.
ab1198726 may be used in conjunction wi...