..We describe the first panel of clinically significant biomarkers with over 99% specificity for autism risk thereby advancing our understanding of the etiologic mechanisms and therapeutic possibilities for MAR autism. ..

Increased midgestational IFN-γ, IL-4 and IL-5 in women bearing a child with autism: A case-control study

..To assay if plasma antibody levels in children with autism or developmental delays (DD) differ from those with typical development as an indicator of immune function and to correlate antibody levels with severity of behavioral symptoms...

..Further longitudinal analyzes of cellular immunity profiles would delineate the relationship between immune dysfunction and the progression of behavioral and developmental changes throughout the course of this disorder...

Increased production of IL-17 in children with autism spectrum disorders and co-morbid asthma

Marjannie Eloi AkintundeSchool of Medicine, Division of Rheumatology, Allergy and Clinical Immunology, University of California, Davis, United States NIEHS Center for Children s Environmental Health, University of California, Davis, United States Electronic addressJ Neuroimmunol 286:33-41. 2015

..In conclusion, children with ASD exhibited a differential response to T cell stimulation with elevated IL-17 production compared to controls. ..

..The characterization of immunological parameters in ASD has important implications for diagnosis, and should be considered when designing therapeutic strategies to treat core symptoms and behavioral impairments of ASD...

Decreased cellular IL-23 but not IL-17 production in children with autism spectrum disorders

Charity OnoreDepartment of Medical Microbiology and Immunology, University of California at Davis, USAJ Neuroimmunol 216:126-9. 2009

..Decreased cellular IL-23 production in ASD warrants further research to determine its role on the generation and survival of T(H)17 cells, a cell subset important in neuroinflammatory conditions that may include ASD...

Maternal autoantibodies are associated with abnormal brain enlargement in a subgroup of children with autism spectrum disorder

..4 times higher when compared to carriers without FXPOI (95% CI 1.1-5.0; P = 0.021). The likelihood of IMD in carriers with or without FXPOI is greater (OR 2.4, 95% CI 1.1-5.0; P = 0.021) compared to that of controls...

..For the past 60 years, the central nervous system has been considered immunologically privileged. Yet results from diverse fields show clear and convincing evidence of bidirectional communication between the nervous and immune systems...

The CHARGE study: an epidemiologic investigation of genetic and environmental factors contributing to autism