Research

Advancing the Study of Competitive GR Antagonists

Investigators are studying mifepristone and compounds from our next generation of competitive GR antagonists to see if they can mitigate the effects of excess cortisol and the serious, sometimes life-threatening conditions that may result. This research addresses a variety of pre-clinical models and potential indications.

Clinical research with mifepristone

Alcohol dependence

Anti-psychotic drug induced weight gain

Prostate, ovarian, and breast cancers in combination with an anti-cancer agent

Cognitive enhancement in late life anxiety disorders

Post-traumatic stress disorder

Effects of Mifepristone on Biomarkers of Metabolic Function and Neuropsychological Performance among Older Middle-Aged Overweight/Obese Individuals