I will briefly review the current picture of non-thermal emission in clusters of galaxies with a particular focus on high-energies. Cosmic-ray protons are confined in galaxy clusters and can accumulate there for cosmological times. Hadronic interactions of cosmic rays with the cluster ambient gas, the intra-cluster medium, generate secondary electrons, gamma-rays and neutrinos. Are we detecting these secondaries? Will we ever detect them? I will present my work aiming to answer these questions.