Depp and Heard, who met while filming 2011’s The Rum Diary, married in a private Los Angeles ceremony in February 2015. Days after, they celebrated with a slightly larger ceremony on Depp’s private island in the Bahamas.

At the time, People reported that “only a few dozen of their closest family and friends look[ed] on as they swapped vows under a white marquee decorated with flowers on the idyllic beach of Little Hall’s Pond Cay.”

The couple first confirmed their relationship after Depp split with his partner of 14 years, French singer and actress Vanessa Paradis, with whom he has one daughter, Lily-Rose, and one son, Jack.

“We connect on a lot of levels but the first things that really got me was she's an aficionado of the blues,” the actor revealed. “I would play a song, some old obscure blues song, and she knew what it was.”

“She’s very very literate,” he added. “She’s a voracious reader as I have been, so we connected on that as well and she’s kind of brilliant and beautiful.”

Last June, while promoting Magic Mike 2, Heard opened up about the marriage, telling The Times of London, “I never thought I would get married. But I’ve always loved who I’ve loved.”

Heard also spoke about the transition from being Depp’s girlfriend to his wife, telling Elle, “Nothing is a dramatic change. We’ve been together for a long time now, so it’s been a fairly organic process . . . I have a fiercely independent spirit.”

“The thing that really scares me is the potential of losing my freedom,” she added to the magazine. “I never want for my life to lose the ability to transverse the world, with freedom and ease.”

Entertainment Tonight notes this is not the first personal setback for Depp this month. The actor’s beloved mother, Betty Sue, died on Friday at 82 after battling a long illness. The actor has a tattoo of his mother’s name inside a heart on his inner arm.

News of the separation also follows the couple’s bizarre saga with Australia’s minister of agriculture, which began after Heard failed to declare the couple’s two teacup-size dogs at customs upon entering the country. Presumably as part of some kind of court agreement, the couple appeared in an awkward P.S.A., during which they apologized for not declaring their pets, and stiffly urged others to not make the same mistake they did.

On Monday evening, Depp appeared onJimmy Kimmel Live in seemingly good spirits.

The appearance was one of several planned this week for Depp to promote Alice Through the Looking Glass, which opens in theaters this Friday.

Representatives for the couple did not immediately respond to VF.com requests.