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In recent decades, event-related potentials have
been used for the clinical electrophysiological assessment
of patients with disorders of consciousness (DOCs). In this
paper, an oddball paradigm with two types of frequencydeviant
stimulus (standard stimuli were pure tones of 1000
Hz; small deviant stimuli were pure tones of 1050 Hz; large
deviant stimuli were pure tones of 1200 Hz) was applied to
elicit mismatch negativity (MMN) in 30 patients with
DOCs diagnosed using the JFK Coma Recovery ScaleRevised
(CRS-R). The results showed that the peak
amplitudes of MMN elicited by both large and small
deviant stimuli were significantly different from baseline.
In terms of the spatial properties of MMN, a significant
interaction effect between conditions (small and large
deviant stimuli) and electrode nodes was centered at the
frontocentral area. Furthermore, correlation coefficients
were calculated between MMN amplitudes and CRS-R
scores for each electrode among all participants to generate
topographic maps. Meanwhile, a significant negative
correlation between the MMN amplitudes elicited by large
deviant stimuli and the CRS-R scores was also found at the
frontocentral area. In consequence, our results combine the
above spatial properties of MMN in patients with DOCs,
and provide a more precise location (frontocentral area) at
which to evaluate the correlation between clinical electrophysiological
assessment and the level of consciousness.
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