1. acronym for "oh my fucking god, what the fuck is this fucking shit"
2.When an occurrence or an event is so umbelievabe, that words can not fully describe just how totally messed up a situation truly is...

Dave took a dump in his friend Eric's bathroom but didn't flush just before going out for the night. After a long and hard night of excessive drinking, Eric stumbles into the bathroom, where a surprise package has been left for him, after three flushes the mess has not completely been washed away, at which point he exclaims "oh my fucking god, what the fuck is this fucking shit!?"
He promptly sends the following text message to Dave with a pic of the mess: omfgwtfitfs