Study on memory, hormones and Alzheimer's disease

Principal Investigator(s):

Maria Natasha Rajah

Description of the study:

• Natasha Rajah’s laboratory is investigating how biological sex, menopausal status in women, and genetic risk factors for Alzheimer's disease (such as apolipoprotein E4 [ApoE4]) influence brain activity, brain structure and memory in healthy adults (18-75 years). In other words, we want to examine if there are sex differences in memory and brain function at midlife. Also, verify the impact of certain genes on memory and brain function.

• In addition, we wish to investigate how hormonal changes during menopausal transition affect memory and brain function in middle-aged women.

• We hope our results will improve our understanding of the influence of aging and genetic risk factors for Alzheimer's disease on memory and brain function in middle-aged adults.