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Abstracts

Objective: To determine the effects of R-loop formation on the FA pathway and to determine the effects of the FA pathway on transcription. Methods: siRNA transfections were used to reduce protein levels of splicing factors.

FANCD2 is a key player in FA pathway. Besides core complex of FA pathway the function of FANCD2 was also regulated by proteins of other DNA repair pathway. It has been shown that PCNA and Rad18 can interact with FANCD2 and regulate FANCD2 momo-ubiquitination.

The misleading terms “induced replisome reactivation”, “blocked replisome” and “replication restart” were introduced in the late1980’s to describe the immediate inhibition and subsequent robust resumption of DNA synthesis in UV-irradiated /E.

Aberrant expression of microRNAs has been correlated with the initiation and progression of many diseases. One such microRNA, miR-155, is an oncogenic microRNA that has been associated with several different types of cancer, including lung, breast, and lymphoma.

Endogenous genome targeting and editing in an efficient and specific manner are technological challenges, particularly in development and translational settings, with significant foreseeable impacts on healthcare.

Beta thalassemia is one of the most common autosomal recessive disorders caused by reduced or absent synthesis of beta globin chains of hemoglobin tetramer. More than 200 disease-causing mutations have been identified so far, and the most frequent ones are point mutations.

Personalized cancer medicine promises to determine why some individuals are at a greater risk for developing cancer and to also improve the outcome for individual cancer patients through the best choice of treatment.

The identification of new diagnostic biomarkers is needed to advance the scope of personalized cancer therapies. In 2008, our laboratory identified a first-in-its-class, germ-line mutation located in the 3’UTR of the KRAS oncogene.

Each day a cell accumulates nearly 20,000 DNA lesions, which, if allowed to persist, can lead to genomic instability and cancer. Single-base DNA lesions are primarily removed and repaired by the base excision repair (BER) pathway.