Significance Statement

Thermoresponsive soft-matter nanovavles locally self-assembled in tiny nanofluidic channels make it possible to actively regulate fluids to a scale as small as femtoliters (a thousand billionth of a liter).

The assembly of functional soft matter in small, microfabricated solid-state nanospaces could be a new arena to exploit possibilities of advanced materials unachievable in the bulk and micrometer scales, because these nanospaces display unusual properties due to their large surface-area-to-volume ratio and short diffusion length and heat transfer distance. Meanwhile, the soft matter assembled in nanospaces provides well-controlled additional functions and promise to greatly improve the capabilities of the nanospaces for the creation of versatile new systems and applications. However, due to their small size, they are difficult to work with. For example, attempts to assemble soft materials in nanofluidic channels, which are typical microfabricated solid-state nanospaces for confining and handling small amounts of fluid, often fail because the channels get clogged by large macromolecules.

Recently a collaborative team led by Prof. Yan Xu and Prof. Atsushi Harada at Osaka Prefecture University has made a breakthrough in assembling functional soft materials in tiny nanofluidic channels. In combination with nanofluidics, they used a nano-in-nano integration technique they developed to assemble nanobrushes of a well-tailored short-chain thermoresponsive polymer in nanofluidic channels. The assembled polymer nanobrushes enable the active regulation of femtoliter-scale fluids inside nanofluidic channels in response to an external temperature change, without clogging.

Such soft matter-regulated active nanovalves within nanofluidic channels could be extended to build well-controlled functional nanofluidic systems, allowing complex fluidic processes to be performed at nanometer scales. In addition, because control of fluids is involved in fields as diverse as chemistry, mechanics, physics, materials science, energy, biology, drug discovery and clinical medicine, this improvement in the ability to actively regulate femtoliter-scale fluids could have a big impact on these fields.

About The Author

Prof. Yan Xu is now a faculty member of Department of Chemical Engineering, Osaka Prefecture University, Japan. He received his Bachelor’s from Dalian University of Technology in 2001, Master’s from Dalian Institute of Chemical Physics, Chinese Academy of Sciences in 2004, and PhD from the University of Tokyo in 2007. Before taking up the position at Osaka Prefecture University in April 2011, he served as a JSPS research fellow and then as a research scientist at the University of Tokyo.

His research group focuses on nanofluidics, single-molecule chemistry, single-cell omics, biomaterials, and nanomedcine.