prejudgments

8/25/2019

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transeunt

8/29/2019

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About me

Evaluation of DNA oxidative damage in normal and neoplastic cells of colonic mucosa in patients with colorectal cancer. Descritores: Estresse Oxidativo. Ensaio em Cometa. Neoplasias Colorretais. Oxidative stress on mucosal cells of the colon, resulting from the action of free radicals present in the intestinal lumen, represents one of the initial phenomena in colorectal carcinogenesis, because it may induce gene mutations relating to cell cycle control. Quantification of the oxidative damage to the DNA in colorectal cancer patients has been little studied so far. OBJECTIVE: To measure the levels of oxidative damage to the DNA in cells isolated from the colon mucosa in colorectal patients, and to compare normal and neoplastic tissues and make correlations with anatomopathological variables.