When Claire Novak (guest star Kathryn Love Newton) gets a lead on her mother, Amelia (guest star Leisha Hailey), who has been missing for years, Castiel (Misha Collins) asks Sam (Jared Padalecki) and Dean (Jensen Ackles) to help her. Castiel feels guilty for what he did to the Novak family and wants to make amends by reuniting Claire with her mom. However, when they find out what took Amelia, they realize there is a chance Claire may not get her happy ending.

This week's episode will take a break from the Mark of Cain curse, and focus on a more humane and emotional theme like finding Claire's mother.

A new promo video shows Castiel asking for Sam and Dean's assistance to help his own daughter Claire. He claims that since the Winchesters have been troubled teenagers, they would know how to potentially help him deal with Claire and search for her mother Amelia.

Another promo shows Claire telling Castiel, "I want to find my mother and tell her how she ruined my life."

Castiel will be forced to address some very humane issues that no angel can process in the episode.