Multiple prostate cancer (PCa) risk-related loci have been discovered by genome-wide association studies (GWAS) based on case-control designs. However, GWAS findings may be confounded by population stratification if cases and controls are inadvertently drawn from different genetic backgrounds. In addition, since these loci were identified in cases with predominantly sporadic disease, little is known about their relationships with hereditary prostate cancer (HPC). The association between seventeen reported PCa susceptibility loci was evaluated with a family-based association test using 1,979 hereditary PCa families of European descent collected by members of the International Consortium for Prostate Cancer Genetics, with a total of 5,730 affected men. The risk alleles for 8 of the 17 loci were significantly over-transmitted from parents to affected offspring, including SNPs residing in 8q24 (regions 1, 2 and 3), 10q11, 11q13, 17q12 (region 1), 17q24 and Xp11. In subgroup analyses, three loci, at 8q24 (regions 1 and 2) plus 17q12, were significantly over-transmitted in hereditary PCa families with five or more affected members, while loci at 3p12, 8q24 (region 2), 11q13, 17q12 (region 1), 17q24 and Xp11 were significantly over-transmitted in HPC families with an average age of diagnosis at 65\ years or less. Our results indicate that at least a subset of PCa risk-related loci identified by case-control GWAS are also associated with disease risk in HPC families.

},
keywords = {2012, Center-Authored Paper, January 2012, Public Health Sciences Division},
issn = {1432-1203},
doi = {10.1002/sim.4430},
author = {Jin, Guangfu and Lu, Lingyi and Cooney, Kathleen A and Ray, Anna M and Zuhlke, Kimberly A and Lange, Ethan M and Cannon-Albright, Lisa A and Camp, Nicola J and Teerlink, Craig C and Fitzgerald, Liesel M and Stanford, Janet L and Wiley, Kathleen E and Isaacs, Sarah D and Walsh, Patrick C and Foulkes, William D and Giles, Graham G and Hopper, John L and Severi, Gianluca and Eeles, Ros and Easton, Doug and Kote-Jarai, Zsofia and Guy, Michelle and Rinckleb, Antje and Maier, Christiane and Vogel, Walther and Cancel-Tassin, Geraldine and Egrot, Christophe and Cussenot, Olivier and Thibodeau, Stephen N and McDonnell, Shannon K and Schaid, Daniel J and Wiklund, Fredrik and Gr{\"o}nberg, Henrik and Emanuelsson, Monica and Whittemore, Alice S and Oakley-Girvan, Ingrid and Hsieh, Chih-Lin and Wahlfors, Tiina and Tammela, Teuvo and Schleutker, Johanna and Catalona, William J and Zheng, S Lilly and Ostrander, Elaine A and Isaacs, William B and Xu, Jianfeng}
}