Choosing Wisely:

Don’t routinely use B vitamin supplements for the treatment of polyneuropathy or neuropathic pain unless a deficiency exists.

There is no indication for supplementing with B vitamins in patients with polyneuropathy unless a deficiency has been detected or is highly likely secondary to other medical factors (e.g., gastric bypass surgery). In addition to being an unnecessary expense, excessive vitamin B-6 can lead to toxicity and cause worsening neuropathy.