Drug Interactions between acetaminophen / propoxyphene and Phenergan

Interactions between your drugs

Major

propoxyphene promethazine

Applies to: acetaminophen / propoxyphene and Phenergan (promethazine)

Using promethazine together with propoxyphene can add to the side effects of either medication. This may be more likely to occur in older adults or those with a debilitating condition. Talk with your doctor before using these medications together. Call the doctor if you have side effects such as tiredness, excessive sedation, dizziness, feel faint, seizures, and/or irregular heartbeat. You should avoid activities requiring mental alertness until they know how these medications will affect you. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Drug and food interactions

Major

propoxyphene food

Applies to: acetaminophen / propoxyphene

Do not use alcohol or medications that contain alcohol while you are receiving treatment with propoxyphene. This may increase nervous system side effects such as drowsiness, dizziness, lightheadedness, difficulty concentrating, and impairment in thinking and judgment. In severe cases, low blood pressure, respiratory distress, fainting, coma, or even death may occur. Do not use more than the recommended dose of propoxyphene, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medication without first talking to your doctor.

See Also

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.

Major

Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.

Moderate

Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.

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Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Data sources include IBM Watson Micromedex (updated 4 May 2020), Cerner Multum™ (updated 2 June 2020), Wolters Kluwer™ (updated 2 May 2020) and others.