Initiated by the Joep Lange Institute, this pre-conference, hosted by a.o. Mark Dybul and Lillian Mworeko, presents a new vision of HIV response, taking sharper aim at reducing new infections, streamlining service delivery, targeting the use of resources, and building sustainable funding approaches. While HIV treatment scale up has been successful in some countries, many countries are struggling to meet current targets. Even where service delivery coverage is high, programs struggle to reach key populations, adolescents and young adults. Increased scale up with insufficient funding threatens the quality of care and may cause harm to patients on treatment. Unless programs improve coverage among these populations, achieving sufficient reductions in infection rates will not be possible to achieve control over the epidemic. The pre-conference reports on a series of meetings recommending innovative approaches for HIV service delivery and investment strategies to maintain and build upon the successes to date.