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When used on a target, the Sanguine Rose summons a random daedra. This daedra may fight for the target or for the player. Unlike the Sanguine Rose that appears in The Elder Scrolls II: Daggerfall, which eventually wilts and is no longer in the player's possession, this version of the Sanguine Rose stays in the player's inventory, and is rechargeable using soul gems, like other magical staves. This item's strength varies. The strongest daedra would probably be a Xivilai, as it can summon another daedra in turn, a Clannfear.

If the Hero were to give this staff to Martin during the quest Blood of the Daedra, he will comment that he once possessed this artifact, albeit briefly. He became a priest after an unspecified incident involving the staff caused the deaths of several of his friends.