The F-15 Eagle is a single seat, twin engine, all weather, air superiority and tactical fighter designed to gain and maintain air superiority in aerial combat, as well as conduct air-to-ground airstrikes and tactical bombing missions.

In Call of Duty: Modern Warfare 2, the F-15 Eagle appears in multiplayer as a killstreak reward. Three F-15 Eagles are unlocked as a 6-kill killstreak, the Precision Airstrike. This airstrike is directional and calls in three F-15s to cluster bomb an area, similar to the Call of Duty 4: Modern Warfare version.

The F-15 appears in Modern Warfare 3's Multiplayer as the Assault Package's 6-point reward, the Precision Airstrike. Much like its predecessor, three planes will fly in a straight direction of the spot where it is launched by the player who called it and drop their payloads. Getting a Game Winning Killcam with this earns the winner the "Finishing Touch" Challenge and 2500exp. Killing 5 enemies at once will earn the "Carpet Bomb" Challenge and 5000 exp. Calling in two Airstrikes in a single match will earn the "Afterburner" Challenge with 2500exp. While in Prestige, getting a certain number of kills will earn the "Carpet Bomber" Challenge of different levels.

The Precision Airstrike compliments well with the Predator Missile and the Attack Helicopter as a 5-6-7 Point Streak combo. With Hardline Pro, the two-assist-kill ability makes it much faster to achieve the combo in 4 points. Land a kill with the Predator Missile to earn the Airstrike. Call it in on a high traffic area to get your 6th point to earn the Helicopter, then call the chopper to gain additional kills as it flies around the map.

All F-15s in the game bear the tail code "IW4" on their vertical stabilizers. The code usually identifies a plane's unit or base assignment, but since "IW4" is not in use by any of those entities, it clearly refers to the game's engine.