RT Journal
A1 Hampton T
T1 ANticancer drugs reduce type 1 diabetes incidence in mice
JF JAMA
JO JAMA
YR 2014
FD March 5
VO 311
IS 9
SP 894
OP 894
DO 10.1001/jama.2014.1870
UL http://dx.doi.org/10.1001/jama.2014.1870
AB
The anticancer drugs were given at 100-fold lower concentrations than doses needed to reduce tumor size in vitro and in animals. When weaning mice received vorinostat or givinostat in their drinking water until 100 to 120 days, diabetes incidence was reduced from 50% to 12% and from 69% to 25%, respectively. Treatment increased insulin production and caused fewer immune cells to enter the pancreas, with a 16% increase in the percentage of islets without immune cell infiltration.