Before Using

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of oxycodone in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of oxycodone in the elderly. However, elderly patients are more likely to have age-related lung, liver, or kidney problems, which may require caution and an adjustment in the dose for patients receiving oxycodone in order to avoid potentially serious side effects.

Pregnancy

Information about this oxycodone-oral-route

Pregnancy Category

Explanation

All Trimesters

C

Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breastfeeding

Studies in women breastfeeding have demonstrated harmful infant effects. An alternative to this medication should be prescribed or you should stop breastfeeding while using this medicine.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

Naltrexone

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Abiraterone Acetate

Acepromazine

Alfentanil

Alprazolam

Alvimopan

Amiodarone

Amisulpride

Amprenavir

Anileridine

Aprepitant

Aripiprazole

Asenapine

Atazanavir

Baclofen

Benperidol

Boceprevir

Brofaromine

Bromazepam

Buprenorphine

Buspirone

Butorphanol

Carisoprodol

Carphenazine

Ceritinib

Chloral Hydrate

Chlordiazepoxide

Chlorpromazine

Chlorzoxazone

Clarithromycin

Clobazam

Clonazepam

Clorazepate

Clorgyline

Clozapine

Cobicistat

Codeine

Conivaptan

Crizotinib

Cyclobenzaprine

Dabrafenib

Darunavir

Delavirdine

Dexmedetomidine

Dezocine

Diacetylmorphine

Diazepam

Dichloralphenazone

Difenoxin

Dihydrocodeine

Diphenhydramine

Diphenoxylate

Doxylamine

Droperidol

Enflurane

Erythromycin

Escitalopram

Eslicarbazepine Acetate

Estazolam

Eszopiclone

Ethchlorvynol

Ethopropazine

Ethylmorphine

Etomidate

Fentanyl

Flunitrazepam

Fluphenazine

Flurazepam

Fluspirilene

Fluvoxamine

Fosaprepitant

Fospropofol

Furazolidone

Halazepam

Haloperidol

Halothane

Hexobarbital

Hydrocodone

Hydromorphone

Hydroxyzine

Idelalisib

Imatinib

Indinavir

Iproniazid

Isocarboxazid

Isoflurane

Itraconazole

Ketamine

Ketazolam

Ketobemidone

Ketoconazole

Lazabemide

Levorphanol

Linezolid

Lomitapide

Loprazolam

Lorazepam

Lormetazepam

Meclizine

Medazepam

Melperone

Meperidine

Meptazinol

Mesoridazine

Metaxalone

Methadone

Methdilazine

Methocarbamol

Methohexital

Methotrimeprazine

Methylene Blue

Methylnaltrexone

Midazolam

Mifepristone

Mitotane

Moclobemide

Molindone

Moricizine

Morphine

Morphine Sulfate Liposome

Nalbuphine

Nalmefene

Nalorphine

Naloxegol

Naloxone

Nefazodone

Nelfinavir

Nialamide

Nicomorphine

Nilotinib

Nitrazepam

Nitrous Oxide

Olanzapine

Opium

Orphenadrine

Oxazepam

Oxycodone

Oxymorphone

Papaveretum

Paregoric

Pargyline

Pentazocine

Perazine

Periciazine

Perphenazine

Phenelzine

Pimozide

Piperacetazine

Piperaquine

Pipotiazine

Piritramide

Posaconazole

Prazepam

Procarbazine

Prochlorperazine

Promazine

Promethazine

Propofol

Propoxyphene

Quazepam

Quetiapine

Ramelteon

Rasagiline

Regorafenib

Remifentanil

Remoxipride

Ritonavir

Samidorphan

Saquinavir

Selegiline

Sertindole

Sertraline

Siltuximab

Sodium Oxybate

Sufentanil

Sulpiride

Suvorexant

Tapentadol

Telaprevir

Telithromycin

Temazepam

Thiopropazate

Thioridazine

Ticagrelor

Tilidine

Tizanidine

Tolonium Chloride

Toloxatone

Topiramate

Tramadol

Tranylcypromine

Triazolam

Trifluoperazine

Trifluperidol

Triflupromazine

Trimeprazine

Zaleplon

Zolpidem

Zopiclone

Zotepine

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Miconazole

Perampanel

Rifampin

St John's Wort

Voriconazole

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

Ethanol

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

Addison's disease (adrenal gland problem) or

Alcohol abuse, or history of or

Brain tumor, history of or

Breathing problems (eg, hypoxia) or

Cancer of the esophagus or colon or

Central nervous system (CNS) depression or

Chronic obstructive pulmonary disease (COPD) or

Cor pulmonale (serious heart condition) or

Drug dependence, especially with narcotics, or history of or

Enlarged prostate (BPH, prostatic hypertrophy) or

Gallbladder disease or gallstones or

Head injuries, history of or

Hypothyroidism (an underactive thyroid) or

Hypovolemia (low blood volume) or

Kyphoscoliosis (curvature of the spine with breathing problems) or

Problems with passing urine or

Psychosis (a mental disease) or

Trouble swallowing or

Weakened physical condition—Use with caution. May increase risk for more serious side effects.

Asthma, severe or

Hypercarbia (high carbon dioxide in the blood) or

Paralytic ileus (intestine stops working and may be blocked) or

Respiratory depression (very slow breathing) or

Stomach or bowel blockage—Should not be used in patients with these conditions.

Hypotension (low blood pressure) or

Pancreatitis (inflammation or swelling of the pancreas) or

Seizures, history of—Use with caution. May make these conditions worse.

Kidney disease, severe or

Liver disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body.