Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

Specificity and Use

NTRK2 / TRKB antibody was raised against synthetic peptide from the region around (and including) phospho Y816 site of human TrkB (BDNF/NT-3 growth factors receptor, TrkB tyrosine kinase, Trk-B) conjugated to an immunogenic carrier protein. The antigen is homologous in rat and mouse.

Epitope:

pTyr816

Specificity:

Specific for TrkB.

Usage:

IHC: Antigen retrieval is essential for use on paraffin sections.

Packaging

Presentation:

Lyophilized. Centrifuge to remove any insoluble material

Reconstitution:

500 µl Sterile water

Storage:

Maintain lyophilized and reconstituted antibodies at -20 °C for long term storage and at 2-8 °C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Description: Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity. Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4. Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2.