In addition, “a significant decrease of total cholesterol was [also] found at doses ≥8 mg/d, and when total cholesterol baseline levels were ≥200 mg/dL.” Overall, the results indicate that melatonin supplementation has notable effects on triglycerides and total cholesterol levels, and is more evident with “higher dose and longer duration, and also [with] a higher concentration of cholesterol levels.” Further studies are required to determine the benefits of melatonin on lipid profile.