Hillary Rodham Clinton has formally resigned as the 67th United States secretary of state, capping a four-year tenure in the office that saw her travel extensively across the world as the country's top diplomat.

In a letter sent to President Barack Obama on Friday shortly before she was to leave the State Department for the last time in her official capacity, Clinton thanked the president for the opportunity to serve in his administration.

Clinton said it had been an honour to be part of his cabinet and that she remained convinced of the "strength and staying power" of the US' global leadership.

"I am more convinced than ever in the strength and staying power of America's global leadership and our capacity to be a force for good in the world," she said in the letter.

Her resignation will be effective on the swearing-in of her successor, John Kerry, who will take the oath of office in a private ceremony later on Friday.

I feel badly for her that she suffered and injury, and I wish her the best of health in the future. I do, however, think she did a shitty job and I'm glad to see her out the door.

What do you think this is? Chiefs Planet or something?

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"Not every one that saith unto me, Lord, Lord, shall enter into the kingdom of heaven; but he that doeth the will of my Father ... And then will I profess unto them, I never knew you: depart from me, ye that work iniquity."

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