PNAS, has just published, online (open access), a complete article of: A.Ogura /R.Yanagimachi/N.Ogonuki, et al : "Spermatozoa and spermatids retrieved from frozen reproductive organs or frozen whole bodies of male mice dog produces normal offspring", in relation to the offspring of viable descendant, after fertilizing by means of microinsemination, current, viable mature oocites with sperms and spermatids (of mice), maintained during 15 years, to temperatures of -20 C (without cryoprotectors), in simple solutions (salt) cryopreservants. We have commented this article 9 days ago, being the first (we believe, the only ones) in outlining via online, a fundamental question:"Spermatozoons: alive or dead "? and that the woolly ancients mammoths would be - sooner or later - returned to the life using sperm of males mammoths maintained in permafrost. Surprisingly in the discussion (cerebral space of any article), they give answer -not with all clarity - to our observations. In our article, we gave our own point of view. It seems that they read our observations, although they didn't mention us.

Another important article of PNAS (online, open access), of responsibility of E. Albuquerque, E. Pereira, Y. Aracava et al.,is the related with the sure preventive and effective treatment against the morbid sharp effects - lethal some times- caused by certain neural toxics (organphosphorus (OP), insecticides: parathion and gases:sarin, soman, tabun) that affect to the nervous central system: SNC (brain and related) and peripheral SNC (nerves), conditioned by the early application of a reversible new inhibitor of the acetilcolinesterasaenzyme (AChe): the galantamina. The paraoxon (metabolite of the parathion) and other gases, when inhibiting AChe irreversibly, suppress neural normal functions, conditioning other some times, lethal. Although in Peru and the rest of the world this affection is treated with atropine, oximas and anticonvulsivants, most of having affected and scientists say that this therapeutic outline, is insufficient. Agriculture peruvian workers -many not warned and unprotected- are affected by these toxics (insecticides). Also, the voluntary drinking a of these insecticides, already climbs like one of the important causes of suicide, in Peru. Of another side, it is known that in certain wars of Middle East and in certain terrorist (Japan, 1995) attacks, these neurotoxics were used, with catastrophic results. The galantamina, has demonstrated high effectiveness in laboratory guinea pigs, lacking alone their application to human volunteers, to validate it.

In 2 previous articles, of our responsibility we postulate that any industrial medicine (antihypertensive, antirrheumatic, etc), is effective alone in a certain percentage of patients. That's to say, some of then are cured, others don't feel any effect and an other group, not alone it didn't improve, but rather they will suffer of pharmacological side-effects. For this reason, the future of therapeutic pharmacology, should go toward the creation of individual, elaborated medications - almost handmade - to the measure of each individual's genetic constitution. Arduous task, already begun, for a french-American visionary, the pharmacologist : Mary V. Relling. To the interested ones, I suggest the reading of this illustrative interview.