Trying to turn around their season after spending the majority of the first six games in the bottom of the AFC South, the Colts must grab a win in Week 7 if they want to salvage their season in any way.

Here are the four biggest pregame storylines ahead of the Week 7 matchup:

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Josh Allen won’t play

After suffering an elbow injury on his throwing arm against the Houston Texans in Week 6, the Bills ruled out their rookie quarterback and labeled him as week-to-week.

With Allen out, the Bills had a choice between veteran Derek Anderson and second-year quarterback Nathan Peterman. They went will Anderson, who has a 54.1 percent career completion percentage.

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