A comma usually follows introductory words, phrases, and clauses.

(1) Adverb clauses before independent clauses When you write, you make a sound in the reader's head. -- Russell Baker

[Rule of thumb: always use a comma with an introductory group of words that has a verb form in it.]

(2) Introductory phrases before independent clausesPrepositional phrases: From the deck, I could not see my father, but I could see my mother facing the ship, her eyes searching to pick me out. -- Jamaica Kincaid

BUT: Omit the comma after introductory prepositional phrases when no misreading would result.

[Rule of thumb: use a comma after an introductory phrase of four words or more.]

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