Born a princess, the daughter of King Rudolf II (Rupert II) of Upper Burgundy. Promised at age two in an arranged marriage as part of a treaty between Rudolf and Hugh of Provence. Married at age 16 to Lothair of Italy, who eventually became king of Italy. Widowed in 950 while still a teenager; Lothair was probably poisoned by his successor to the throne, Berengarius. As part of his attempt to solidify his grip on power, Berengarius ordered Adelaide to marry his son; she refused, and was imprisoned. She was freed soon after when the GermankingOtto the Great defeated Berengarius.

When Otto IIdied in 983, he was succeeded by his infant son, Otto III. Theophano acted as regent, and since she still did not like Adelaide, used her power to exile her from the royal court. Theophano died in 991, and Adelaide returned once again to the court to act as regent for the child emperor. She used her position and power to help the poor, to evangelize, especially among the Slavs, and to build and restore monasteries and churches. When Otto III was old enough, Adelaide retired to the convent of Selta near Cologne, a house she had built. Though she never became a nun, she spent the rest of her days there in prayer.