A cell-based reporter gene assay has been developed and used for the screening of the human NMU2R agonist.

Mouse (Murine) Neuromedin U Receptor 2 (NMUR2) interaction partners

The present data do not support a significant contribution of NMUR2 to the development of hypersensitivity after nerve injury or tissue inflammation

Data show that deficiency of neuromedin receptors NMUR1 (show NMUR1 Proteins) and NMUR2 had no impact on arthritis severity.

The circadian rhythm of neuromedin U (show NMU Proteins) expression in the suprachiasmatic nucleus does not drive a circadian rhythm of corticotrophin-releasing factor (show CRH Proteins) in the paraventricular nucleus.

molecular basis of the NMU2R regulation of food intake and body weight in mice

the pro-nociceptive effects of neuromedin U (show NMU Proteins) in mice appear to be mediated through NMUR2, not NMUR1 (show NMUR1 Proteins)

Long-term central NMU (show NMU Proteins) treatment reduces body weight, food intake, and adiposity and that central NMUR2 signaling is required for these effects in female but not male mice.

NMUR2 Protein Profile

Protein Summary

This gene encodes a protein from the G-protein coupled receptor 1 family. This protein is a receptor for neuromedin U, which is a neuropeptide that is widely distributed in the gut and central nervous system. This receptor plays an important role in the regulation of food intake and body weight.