Inadequate restriction of tyrosine and phenylalanine intake can result in elevations of plasma tyrosine

At plasma tyrosine levels above 500 micromol/L, symptoms can occur including intellectual disability and developmental delay or painful hyperkeratotic plaques (thickening of the skin) on the soles and palms

Do not adjust the dosage of NITYR in order to lower the levels of tyrosine in the blood

Changes in blood profile

Patients can develop leukopenia (reduction in the number of white blood cells, which form part of the immune system) and severe thrombocytopenia (abnormally low levels of platelets, which help the blood clot)

Your healthcare professional will monitor platelet and white blood cell counts, and will adjust your medication accordingly
If you have a question about your dosage, or if you experience any of the symptoms explained above, please speak to your healthcare professional.