Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )

Length:

66

Sequences:

748

Seq/Len:

11.33

HH_delta:

0.864 (20Jul13)

GREMLIN Results:
Residue pairs sorted by strength in covariance:Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

i

j

Raw Score

Scaled Score

38_R

42_L

0.69447

3.640

29_R

62_E

0.68844

3.608

42_L

56_G

0.35007

1.835

50_E

55_W

0.32292

1.692

16_F

56_G

0.31266

1.639

45_A

55_W

0.29346

1.538

59_T

63_R

0.28144

1.475

19_R

23_R

0.27752

1.454

42_L

46_L

0.27354

1.434

24_S

27_E

0.26276

1.377

46_L

60_E

0.24433

1.281

11_D

28_A

0.24102

1.263

33_A

38_R

0.23701

1.242

44_Y

52_H

0.23024

1.207

44_Y

50_E

0.22501

1.179

43_E

47_D

0.22363

1.172

14_L

64_R

0.22278

1.168

9_G

12_P

0.21797

1.142

49_R

54_V

0.2107

1.104

52_H

60_E

0.20391

1.069

23_R

54_V

0.2008

1.052

18_E

23_R

0.19994

1.048

57_G

60_E

0.19991

1.048

3_E

10_T

0.19976

1.047

20_G

63_R

0.19738

1.034

15_F

28_A

0.197

1.032

18_E

26_R

0.19318

1.012

4_R

33_A

0.19038

0.998

31_I

37_V

0.18949

0.993

6_A

31_I

0.18869

0.989

10_T

14_L

0.18869

0.989

59_T

62_E

0.18157

0.952

4_R

36_P

0.18013

0.944

10_T

30_A

0.17971

0.942

15_F

60_E

0.17788

0.932

6_A

9_G

0.1768

0.927

48_T

51_E

0.17552

0.920

4_R

34_R

0.17456

0.915

28_A

31_I

0.17414

0.913

15_F

26_R

0.17329

0.908

11_D

30_A

0.17101

0.896

23_R

44_Y

0.17068

0.895

16_F

20_G

0.17064

0.894

11_D

57_G

0.17

0.891

39_A

43_E

0.16869

0.884

30_A

33_A

0.16792

0.880

13_D

16_F

0.16774

0.879

45_A

56_G

0.16746

0.878

27_E

30_A

0.16743

0.877

42_L

62_E

0.16514

0.865

60_E

63_R

0.16251

0.852

11_D

16_F

0.16238

0.851

4_R

27_E

0.16215

0.850

56_G

59_T

0.16043

0.841

16_F

28_A

0.158

0.828

10_T

49_R

0.157

0.823

40_E

48_T

0.15626

0.819

4_R

39_A

0.15568

0.816

17_P

63_R

0.15562

0.816

42_L

58_L

0.15499

0.812

18_E

44_Y

0.15444

0.809

5_A

30_A

0.15304

0.802

6_A

39_A

0.15266

0.800

34_R

43_E

0.151

0.791

49_R

58_L

0.15074

0.790

19_R

40_E

0.14839

0.778

33_A

39_A

0.14702

0.771

50_E

56_G

0.14383

0.754

10_T

13_D

0.14328

0.751

3_E

36_P

0.14296

0.749

3_E

49_R

0.14111

0.740

26_R

34_R

0.14088

0.738

19_R

44_Y

0.13894

0.728

30_A

47_D

0.13869

0.727

14_L

58_L

0.13781

0.722

51_E

61_R

0.1362

0.714

26_R

52_H

0.13431

0.704

29_R

53_G

0.13378

0.701

38_R

58_L

0.13306

0.697

34_R

49_R

0.13231

0.693

28_A

55_W

0.13181

0.691

23_R

37_V

0.13175

0.690

40_E

43_E

0.13157

0.690

19_R

27_E

0.12964

0.679

4_R

40_E

0.12915

0.677

14_L

34_R

0.12875

0.675

25_A

61_R

0.12837

0.673

6_A

26_R

0.1282

0.672

29_R

45_A

0.12747

0.668

38_R

57_G

0.12677

0.664

Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.

HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits: Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)