The genus Andinophryne, characterized by the presence of an omosternum, an externally visible tympanum, elongate parotoids and extensively webbed hands and feet is described from the Pacific versant of the Andes in northwestern Ecuador and southwestern Colombia. Two new species, Andinophryne colomai and A. olallai are described from Ecuador. The recently described Bufo atelopoides Lynch & Ruiz-Carranza is transferred to the new genus. Some comparisons with other atelopodid Bufonidae (Atelopus, Dendrophryniscus, Melanophryniscus, Oreophrynella, Osornophryne, Rhamphophryne) are made and some very tentative remarks on their relationships are ventilated.