The PNMA1 gene encodes an antineuronal antibody (anti-Ma) present in patients with paraneoplastic neurologic disorders;(Dalmau et al., 1999 (PubMed 10050892)). Some paraneoplastic syndromes affecting the nervous system are associated;with antibodies that react with neuronal proteins and the causal tumor (onconeuronal antigens) (summarized by Dalmau;et al., 1999 (PubMed 10050892)). Several of these antibodies are markers of specific neurologic syndromes associated;with distinct types of cancer. The presence of some antibodies is so specific that disorders previously identified by;brain biopsy or at autopsy can be diagnosed serologically. The expression of neuronal proteins by the tumor appears to;be a crucial step that breaks the immune tolerance for otherwise normal neuronal proteins. The identity of most;onconeuronal antigens was established by probing human cDNA expression libraries with serum containing antineuronal;antibodies.

Protein Function

PNMA1 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PNMA1 itself. We selected most functions PNMA1 had, and list some proteins which have the same functions with PNMA1. You can find most of the proteins on our site.

Interacting Protein

PNMA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PNMA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PNMA1.