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The concept, which originated on Dr. Phil, mostly focuses on health and medical issues, as a team of medical professionals (and sometimes celebrity guests/speakers) discuss a range of various health-related topics and answer questions from viewers who are too embarrassed to ask their own doctors.

On May 6, 2011, it was announced that Jillian Michaels had been added to the cast of The Doctors doing mainly segments outside the studio, along with serving as a "special correspondent" on Dr. Phil."[8]Wendy Walsh, a psychotherapist and relationship expert seen usually in pundit panels on CNN and HLN, was announced as a fifth regular panelist to the show on September 1, 2011, to start as of September 12.[9]

During the holiday break at the end of 2011, Michaels left the show to return to The Biggest Loser, with Walsh also departing the series and returning it to the original four-doctor format for the 2012 season. Lisa Masterson did not return for the sixth season. UrologistJennifer Berman and family medicine physician and sexologist Rachael Ross joined the series.[1]

The show had not ranked in the top 20 syndicated programs at all during the beginning of its first season, coming in behind the syndicated version of the game show Deal or No Deal among new syndicated programs, garnering a 1.3 rating at the time of its launch.[11] In 2009 it had a 1.5 rating by the end of October, up to 1.9 by December, and 2.3 by January, surpassing Deal or No Deal; the show remains the top new talk show of the season.[12]

In Buffalo, New York, the show was credited in 2008 with increasing the lead-in for WKBW-TV's 5:00 newscasts, to the point that the station was competitive with other stations in the market.[13]

A 2014 study in the British Medical Journal examined 40 randomly-selected episodes of The Doctors and studied the veracity of 80 randomly-selected statements or recommendations made in each episode. The study determined that "evidence supported 63%, contradicted 14%, and was not found for 24%" of recommendations made by the panel of doctors, and advised that "the public should be skeptical about recommendations made on medical talk shows."[14]

In Canada, a French version called Les Docteurs airs on Radio-Canada (simultaneously with The Doctors, which airs on a different channel at that time). The show, whose format is identical to the previous seasons of the English version, features French-Canadian doctors in a similar-looking set with the same color scheme and French wording, though it did not license the theme song and goes without sound effects.[15]

In Mexico, a Latin American version called Los Doctores is airs on Televisa.[16] In Malaysia, a Malay version of The Doctors called MY Doctors airs on Astro Ria. In Lebanon, an Arabic version of The Doctors is aired on MTV. In Vietnam, the program is called Các Bác sĩ nói gì? (What did the Doctors say?). In Portugal, the show airs in English with Portuguese subtitles on SIC.

In Egypt, after the end of Al-Bernameg, rumors surfaced on the internet that Egyptian satirist Bassem Youssef will return with a new program on Egyptian television that has no relation with satire and politics. Bassem denied the rumors.