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"My name is Alice. And I remember everything."
— Alice to Dr.Isaacs after regaining her memories

Alice was a leading party in the conflict against the Umbrella Corporation during the Global T-virus Pandemic. Originally a high-ranking Umbrella security operative, she joined a deep cover operation by members of the US law enforcement to reveal the company's illegal viral research data to the world. This plan ultimately failed when her co-worker, Spence stole the virus samples with the intention of getting rich on the black market and leaked the virus into the lab to kill the research staff in the confusion. Both Alice and Spence were knocked unconscious when the security system released noxious gas and were rendered amnesiac.

Infected after escaping the Undead-infested facility, Alice was taken away by Umbrella for testing. Enhanced by a T-virus infection; cured and re-infected, Alice became the test subject of an Umbrella research project designated "Project Alice"; granted with superhuman abilities, she was able to survive the viral outbreak in Raccoon City and several years of the T-virus' spread across the Earth. As she had not succumbed to the T-virus and transformed into an Undead, the acquisition of Alice became a major goal to the company as a means of surviving the pandemic. Alice ultimately crippled Umbrella's leadership nonetheless, paving the way for its Red Queen computer system to take full control of its remaining assets, now intent on humanity's destruction. Unknown to Alice, this was another Umbrella ploy to wipe out humanity, a ploy that was highly successful.
After exposure to the T-Virus, Alice's abilities became enhanced.
Following the fall of Washington, DC, Alice was contacted by the Red Queen to bring a final end to the Global T-Virus pandemic and Umbrella. With the help of Claire Redfield, Alice returned to the Hive where she discovered her true nature as a clone of Alicia Marcus. With the aid of the Red Queen, Claire and Alicia, Alice destroyed the Hive and Umbrella and unleashed an anti-virus capable of bringing an end to the global pandemic.

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Alice was created by Umbrella as a clone of Alicia Marcus, the daughter of co-founder James Marcus. Alice's purpose was to protect the Looking Glass House and she remained unaware of her true nature as a clone, thinking that she was the original as all Umbrella clones were created to believe. To the public, she was married to Spence; however, their marriage was a sham for the sake of guarding the mansion. They became romantically involved at some point down the line.

Having access to "security codes, surveillance plans, the works", Alice offered to help Lisa accomplish her mission

In 2002, Alice began talking to an Umbrella researcher named Lisa Addison, who was secretly a mole working for former FBI agent Matt Addison. Rather than arrest her, Alice offered to help Lisa expose Umbrella's bio-weapons research through a plan to disable the Red Queen security system and allow the theft of a T-virus sample. Alice had likely been influenced by Alicia's innate sense of compassion. Unbeknownst to them, Spence discovered this plan. Considering the takedown of Umbrella in this manner to be a worthless accomplishment, he instead made his own plan to steal a sample of the virus with his own security clearance, sell it on the black market and run away with Alice with the market money.

When Alice returned, Spence initiated sex with her, hoping to tire her out and make Alice sleep for a while. The plan worked, with Alice snoozing away. She awoke later, finding Spence gone; she picked out some clothes to wear and went for a shower. However, Spence caused the mansion's defense systems to activate by releasing the T-virus into the Hive.

Knocked out by the Red Queen's release of gas, Alice woke up naked in the bathroom in an amnesiac condition, having no recollection of who or where she was. Briefly exploring the mansion in a failed attempt to look for clues to her identity, she was met by Addison, who had come for Anna and the virus sample. Umbrella's "Sanitation" commando team arrived right after; its leader James Shade demanded information from Alice. Accepting her amnesia but not having enough commandos to stay upstairs, Alice and Addison - their prisoner - were taken into The Hive as they investigated the reason for the security system killing the research staff. On their way they found Spence, who had also been rendered amnesiac due to the nerve gas.

When the mission successfully deactivate the Red Queen, it was revealed that the entire staff had been infected with the T-virus and, consequently, the security system was no longer able to prevent the Undead researchers from escaping. The group had lost several commandos in a trap set by the security system, so was incapable in fighting off the escaped Undead, resulting in the infection of almost the entire team. Forced to climb through ventilation, they aimed to reach the train before their escape could be sealed off. Breaking from the group, Alice became aware of her martial arts skills when she instinctively kicked an Undead dog. Moving through the lab, she remembered the existence of the Anti-Virus; the team followed her in search of it. Entering the viral research lab to find it empty of both the T-virus and Anti-Virus, Spence remembered his actions and turned on the others. With Alice unwilling to come with him as he explained his original plan, she was left locked with the others as he ran to the train station where he hid the vials.

They soon after escaped the lab and retrieved the vials from his body, Spence having been killed by one of the escaped creatures. Spence revived as an Undead, which Alice killed with glee; she promptly abandoned her wedding ring with his corpse. They boarded the train and took the Anti-virus; however, a Licker attacked them, scratching Matt and Rain turned into a Undead. The Licker kicked Kaplan, while Alice killed Rain and the Licker

Alice wakes up after further experimentation.

Alice and Matt got to the surface; however, they were prevented from taking the Anti-virus by backup from Umbrella, who wanted answers. They were both seized and taken into quarantine at Raccoon General Hospital. Alice was experimented on, along with Matt, who became the monstrous Nemesis. Alice, on the other hand, did not mutate when injected with the T-virus, instead evolving into a better human being.

During the viral outbreak in Raccoon City, Alice was released by Major Cain to combat their latest bio-weapon "Nemesis" (a mutated Matt Addison). After escaping the hospital, Alice learns that the T-virus had escaped The Hive and was now spread into the civil population of Raccoon City, transforming its citizens into Undead. Alice also discovers that she has been genetically altered by exposure to the T-virus; her memories of how it happened were blurred and full of missing information. After dressing and arming herself while wandering the city, Alice senses several survivors Jill Valentine; Peyton Wells, and Terri Morales were in trouble with a heavy presence of the T-virus surrounding their location.

Alice's abilities have made her aware of other organisms infected with the T-virus, such as Angela Ashford. After saving the survivors, Jill Valentine demands an explanation on how Alice knew they were inside the church. Alice evades the question and instead explains her knowledge regarding the events leading into the outbreak at Raccoon City, telling them that she used to work for Umbrella. After receiving a phone call from Dr. Ashford the survivors make a deal to rescue his daughter from her school in exchange for a safe route out of the city.

Alice vs. Nemesis.

Alice and the others' paths were divided when the Nemesis ambushes them and kills Peyton. Alice opts to fight the Nemesis while the others escape in order to locate Angela at the school. Alice was bested by Nemesis in their first encounter and barely escapes with her life. She later reunites with the others at the school, arriving in time to rescue Jill and Angela from the undead dogs who had been stalking them. She ignites the gas from the kitchen stove with a cigarette, killing the dogs in the explosion. The three then meet Carlos Olivera, who was also sent by Ashford to look for Angela.

The group arrives at city hall, unaware that Major Cain has intervened with Dr. Ashford's plan. He captures Alice and the others and demands to see a demonstration of Alice's abilities against the Nemesis. He explains that Alice was unique and adapted to the changes from the T-virus, unlike her counterpart. Alice refuses to fight until Cain shoots Dr. Ashford and threatens to kill everyone else if she continues to object. She fights Nemesis until she gains the upper hand and impales him on a sharp metal object. During the fight, she experiences a flashback that reveals that the Nemesis was actually Matt Addison, who had been subjected to Umbrella's experiments alongside her. Cain orders Nemesis' immediate execution, but Alice refuses the order and the offer to rejoin the Umbrella corporation at his side. Disappointed, Cain orders Matt to kill her, however, the Nemesis rebels - implying that he remembers Alice from The Hive - and attacks the Umbrella soldiers instead. He aids Alice and the others in their fight to escape. He later protects Alice from the helicopters trying to kill her, taking them out with one shot from his rocket launcher. Alice tries to evade the crash, but was rendered unconscious by flying shrapnel from one of the helicopters. She later regains consciousness when Carlos and Angela go to retrieve her. As she was pulled to her feet, she spots the Nemesis' hand sticking out from underneath the burning wreck of one of the helicopters.

When the nuclear strike ordered by Major Cain occurs, the helicopter Alice and the others use to escape was caught by the shock waves from the blast. A pole of some sort inside the helicopter was shaken loose by the blast and spins toward Angela. Alice throws herself in front of the girl and as a result, was impaled by the pole. Alice was only partially aware of the helicopter crash before she dies, catching flashes of the event as it happens. The others pull her from the crash and cover her body. Two hours later, her body was retrieved from the Arklay Mountains by Umbrella scientists, lead by a clone of Doctor Dr. Alexander Isaacs.

3 weeks after the outbreak in Raccoon City, Alice has been taken to a Umbrella facility in Detroit. She wakes from stasis in a tank, with no memory of the outbreak or The Hive. It was revealed that Dr. Isaacs reanimated Alice with a new strain of the t-Virus which gave her telekinetic abilities, making her Umbrella's most successful experiment. When asked about her name or any indication of the incident, Alice's memories return and she responds, "My name is Alice. And I remember everything,". She attacks Dr. Isaacs and his team, demonstrating her new-found abilities; when an Umbrella guard shoots her with a Taser, she remains unharmed by the electrical current and uses the weapon against it's wielder by tossing the wires back at him. During her escape, she somehow detects she was being watched by one of the security guards and was able to kill with a mere glance through the monitors. During her escape, Alice was confronted by a dozen armed soldiers waiting outside, ready to kill her, when Jill Valentine and Carlos Olivera (posing as Umbrella operatives) intervene. During their departure, Dr. Isaacs orders the security guards to let them go. He then orders the activation of Project Alice.

After escaping the laboratory in Detroit, Alice leaves the group, realizing that she was a threat to her companions, and sets out across the deserted American landscape, presumably as the global outbreak occurs. She downloaded a plan detailing when the Umbrella satellites would be around; with this knowledge, she hid from their eyes in the sky to avoid further experimentation and being forced to kill against her will.

Five years later, she responds to a call for help from an abandoned radio station. The call was a trap, however, and Alice was captured by a group of psychopaths and thrown into a pit of Cerberus' for their amusement. Instead, Alice outwitted her captors and left them to their fates, being ripped apart by the Cerberus.

All the while, her psionic powers were growing, which proved to be a risk, as Umbrella could detect the effects of those powers and track her. They proved useful, however when she came across the convoy led by Claire Redfield, and used her powers to expand a cloud of fire to wipe out a swarm of infected crows and saved Carlos from being burnt alive, after which she passed out and awoke a few hours later.

Alice informed the surviving convoy members, Carlos and L.J. among them, of a supposedly uninfected outpost in Alaska (Arcadia), and it was agreed that the convoy would head there after scouring the ruins of Las Vegas for supplies.

It was there than Sam Isaacs set a trap for her, with a shipping crate full of Super Undead. Using a signal to "deactivate her" (eventually activating her implanted neural dampener) Isaacs prepared to collect her body. But Alice was able to fight off the paralyzing influence, and massacred Isaacs' strike team. She had the chance to shoot down his helicopter, but realized that it could be the convoy's ticket to Alaska.

She shows her love to Carlos by sharing a romantic kiss with him just before he sacrifices himself. Carlos, who had been infected by an infected L.J, drove a rigged tanker truck into a swarm of Undead, sacrificing himself to allow the survivors into the nearby Umbrella facility, where the convoy survivors lifted off.

Alice, though, decided to stay behind, and finished things with Umbrella once and for all. What she found was carnage. Dozens of corpses, all with her face, filled a ditch on the grounds of the facility; clones, created by Isaacs to further his research into the virus and the anti-virus. She descended into the lab to find it destroyed.

Alice, final fight with the Tyrant

Amidst the wreckage was the White Queen, an AI similar to the one she had encountered five years prior in The Hive. The Queen informed her that her blood was the key to purging the world of the t-Virus. The computer offered to help, but they could not proceed until Isaacs, now a hideous mutant (The Tyrant), was killed. Alice fought the monster in a replica of the Spencer Mansion and the Hive, the battle eventually moved into a recreation of the laser hall.

Alice's clones waking from suspended animation.

Before Isaacs could strike a killing blow however, the laser grid activated, slicing through the creature and continuing toward Alice. Bracing herself for the end, she was surprised when the lasers deactivated. They had in fact, been controlled by another of her clones, woken up during her fight with Isaacs. A few hours later, Alice appeared, via hologram, at an Umbrella board meeting. She faced down chairman Albert Wesker, vowing to come for him, and "bring a few of my friends." Outside, as she and the first clone looked on, the others began to wake up.

In Resident Evil: Afterlife, Alice and her clones assault the Tokyo headquarters of the Umbrella Corporation. The clones kill everyone except Albert Wesker who escapes in a helicopter and activates a bomb that destroys the facility and kills all of Alice's clones. Alice escapes on the chopper with him and holds a gun to his head, preparing to execute Wesker, but he injects her with a serum that destroys the T cells in her body and renders her powerless. Wesker reveals that he has taken the t-Virus too and displays similar powers to Alice, defeating her and asks her for her last words.

Alice thanks Wesker, happy he removed her powers as she's now fully human again. As Wesker prepares to kill her, the pilot-less helicopter crashes. Alice was presumably the only survivor. Six months later, Alice pilots a two-seater plane to Alaska in hopes of finding Arcadia and the other survivors. Instead, Alice discovers a field of abandoned planes and choppers. She later finds the chopper flown by Claire Redfield abandoned on a nearby beach with the journal she gave K-Mart still inside, but nothing else. As she wonders what to do next, she was attacked and defeats her assailant but was shocked to see that its Claire with a Scarab device on her chest. Alice removes the device, but finds that Claire suffers memory-loss from a drug the device injected her with.

The two journey to Los Angeles where they find thousands of Undead surrounding the Citadel Correctional Facility, which houses a small group of survivors. Alice crash lands on the roof after and the group, lead by Luther West and Angel Ortiz, was disappointed Alice was not from Arcadia and reveals the safe haven was actually a ship, now moored in the harbor. Alice guesses it must be traveling up and down the West Coast retrieving survivors from various locations.

In the facility's prison Alice meets (and Claire was reunited with) Chris Redfield. Shortly after, Axeman attacks and lets in the Undead horde, forcing the survivors to abandon the prison. Alice's plane was hijacked by Bennett and the only escape vehicle was unusable due to the engine having been removed. Alice leads an escape through a tunnel dug by Undead that leads into the storm drains.

Alice, Claire and Chris end up the only survivors and make their way to Arcadia. There, they find Alice's plane crashed on the deck, but no sign of Bennett. Though the ship was abandoned, the log states over 2,000 people are still aboard. The trio discover a cargo hold with the Umbrella logo on it. Claire's memory of the events in Alaska returns and Alice realizes that Arcadia was an Umbrella trap to lure survivors into their grasp. Alice leaves Chris and Claire the duty of freeing the prisoners (starting with K-Mart), while she follows a blood trail to another room. Once inside, she discovers Albert Wesker was alive and well. Wesker reveals that his t-Virus powers allowed him to regenerate, but unlike Alice, the t-Virus was taking him over and he believed that feeding on her flesh will allow him to regain full control of himself. His actions and insanity were why the crew abandoned ship and he holds her at bay with an armed Bennett and two Undead dogs. However, Claire and Chris step in and Alice reminds him that she promised to "bring a few friends" along with her when she faced him.

Alice blows Wesker's brains out.

Claire and Chris unsuccessfully battle Wesker while Alice kills the Undead dogs with one of her shotguns and wounds Wesker with a knife to the head. Bennett thwarts her attempt to get her other shotgun to finish him off, but he's stopped by a recovered K-Mart who knocks him out and tosses Alice back her shotgun, allowing her to blow a massive hole through Wesker's head and free Claire and Chris. Wesker survives his wound, so Claire and Chris unload their pistols into him and trap him with Bennett. Wesker regenerates, kills Bennett and escapes on another chopper and activates another bomb to blow up the Arcadia. Alice quickly calls Chris and Claire to escape the cargo hold, but merely to watch as his plane was destroyed. Prior to her encounter with Wesker, Alice had removed the ship's bomb and placed it inside the plane he would later use to escape.

With a ship full of over 2,000 survivors, Alice decides to turn Arcadia into a real sanctuary for survivors and broadcasts her own message of hope to draw survivors to the ship. Soon after a massive Umbrella force of tiltrotors commanded by Jill Valentine, who had fallen under Umbrella´s control, approached the ship. Alice was injured in the ensuing battle upon the destruction of a Umbrella osprey and was thrown overboard.

Recovered from the waters by the Umbrella Corporation, Alice was taken to a bio weapons testing facility known as Umbrella Prime. When Alice wakes, Jill Valentine appears and begins an interrogation. After several unsuccessful attempts, the power unexpectedly goes out allowing Alice to escape from her cell.

After escaping a laser grid defense measure, Alice finds herself in a simulation of Tokyo where she battles a horde of Undead that include Japan's patient zero. About to be overwhelmed, Alice flees through a door that leads back into the facility and enters the Operations Center only to find the personnel dead. Alice encounters Ada Wong - immediately recognizing her as the associate of Wesker. Wesker appears on a monitor and Ada explains that she and Wesker no longer work for Umbrella as the supercomputer Red Queen has taken over the Umbrella Corporation.

While Alice wants to blast her way out of a window to escape, Ada reveals to her that they were located beneath an ice field. Wesker informs Alice that he has sent her help in the form of a team led by Leon Kennedy. They set out to reach the suburban recreation of Raccoon City after a brief conversation with the Red Queen, who promptly threatens them that they were going to die.

Alice and Ada were able to reach the simulation of Raccoon City - after a brief battle in the New York simulation against two Axemen. During their trip, Alice locates a young girl named Becky who believed Alice was her mother. Alice recognizes the girl from her remembrances of the clone's experience and vows to protect her. While trying to escape the house, the group encounters Jill and a group of soldiers including Rain Ocampo, Carlos Olivera, and One. A shootout occurs, resulting in Ada's capture and Alice and Becky's escape. Entering the Moscow simulation, they encounter a second clone of Rain who Alice asks to look after Becky as she goes forward to meet the rescue team. Alice enters the Moscow environment and rescues the group from a collection of Las Plagas Undead and a Licker. They return to Becky and Rain to escape.

With time to spare the team reaches the elevators; however, the Licker captures Becky while Jill and the clones return and open fire. Alice pursues the Licker to rescue Becky, finding her in a cocoon with the Licker. Alice disables the Licker and rescues Becky. After she recovers explosives, Alice and Becky travel through a tunnel and find the cloning chamber where they find hundreds of clones of themselves. Alice reassures the girl that she was her mother and they are again attacked by the Licker. Using the explosives from earlier, Alice destroys the Licker and escapes with the child. They reach the surface and reunite with the rescue team while Umbrella Prime floods beneath them when the explosives go off.

Alice Vs. Jill Valentine

Shortly afterward the rescue team was intercepted by a surviving Jill and her enforcer, the clone of Rain. While Rain fights Leon and Luther, Jill and Alice fight. Despite being severely injured, Alice manages to break the Scarab free from Jill's chest and frees her from the Red Queen's influence. Alice joins Leon in fighting Rain - who has injected herself with a Plaga parasite - but both were overpowered by the enhanced clone. After being severely injured by a hit to her chest, Alice noticed a collection of Las Plagas Undead beneath the ice. With the help of the freed Jill, Alice stops Rain by breaking the ice beneath her feet. A rescue vehicle arrives to save them, but Alice collapses from her injuries.

When she awakens, Alice was taken to the Oval Office in the White House. Escorted into the room alone, Alice finds herself facing Wesker. He immediately injects her with a sample of the T-Virus and she collapses again. He informs her he has returned to her her gifts in exchange for her help in defeating the Red Queen, who was set on destroying all that remains of humanity. She vows to kill him for what he's done to her and he taunts her by showing her the waves of undead that wait outside the White House barricades.

Wesker's aid of Alice proves to be a trap to destroy what's left of humanity. Wesker destroys the White House and everyone inside of it, leaving only Alice alive inside the rubble.

Awakening in the rubble, Alice makes her way through the ruins of Washington, DC, fighting off two mutated creatures. As she makes her way through the ruins, Alice is drawn into a building by a siren sounding and is contacted by the Red Queen over the computer monitors in the room. To Alice's surprise, the Red Queen doesn't want to gloat but instead to have Alice stop her and Umbrella. The Red Queen states that the last human settlement will be destroyed in 48 hours and resets Alice's watch to a timer matching this. The Red Queen informs Alice of a solution: a potent anti-virus developed by Umbrella and kept in the Hive that will kill anything infected with the T-virus on contact and end the Global T-Virus pandemic. The Red Queen urges Alice to return to Raccoon City and the Hive and reminds Alice that ten years before, the two of them failed to stop Umbrella from destroying the world and Alice can't afford to do that again.

Alice begins making her way to Raccoon City, finding an intact Umbrella motorcycle in the rubble along the way. Alice is caught in an Umbrella trap, but kills the soldiers who attack her and escapes. However, as Alice is not an authorized user of the motorcycle, it shocks her unconscious. Alice awakens inside an Umbrella tank with several chained people and, to her surprise, Doctor Alexander Isaacs as Alice had previously killed him. Alice realizes that the Isaacs she killed was a clone while Isaacs realizes that Alice knows of the anti-virus. To force her to talk, Isaacs drags Alice behind the tank which has a horde of thousands of Undead following it. Alice eventually manages to reboard the tank and kills two Umbrella guards before fighting Isaacs. Spotting a compartment containing a motorcycle, Alice opens it and chops off Isaacs' hand to use it to activate the motorcycle. While the soldiers in the tank attempt to stop Alice, she is able to avoid their fire and escape on the motorcycle.

Reaching Raccoon City, Alice spots a ruined tower on which someone also spots her. As Alice makes her way towards the tower, the last human settlement, she falls into a trap and is knocked unconscious. Upon waking up, Alice takes a hostage leading a tense standoff before Claire Redfield arrives, recognizes Alice and ends the standoff. Claire explains her escape from Umbrella and Alice warns the people of the settlement of the approaching Undead army led by two Umbrella tanks and the Red Queen's plan to end the pandemic. While skeptical, Claire agrees to help Alice reach the Hive and the anti-virus if Alice will help them stop the army.

Alice helps the tower's inhabitants prepare their defenses and when Isaacs and his army arrive, commands the defense of the tower. Under Alice's command, one tank is destroyed with a makeshift bomb make out of a flaming gasoline drum. When the gate is overrun, Alice orders Claire to hold the inner gates until most of the Undead army is inside then releases waterfalls of gasoline upon the Undead which is then ignited, incinerating most of the Undead army. Alice then attacks Isaacs' tank, pouring gasoline inside of it and igniting the gasoline, killing the tank crew. Entering, Alice frees the prisoners in the tank, but discovers that Isaacs has escaped. To get rid of the few remaining Undead, Alice attaches a final Umbrella soldier to the back of Isaacs' tank and sends it driving away, drawing away the few surviving Undead. She is then informed that there are two more armies of Undead coming and they can't stop them.

With no other options left, Alice leads a team down into the crater from the nuclear blast and towards the exposed entrance to the Hive at the bottom. Along the way, they are attacked by a massive pack of Cerberus sent by Wesker and barely make it into the Hive alive. The team makes their way into the Hive, but loses a member when Wesker reverses the air intake fans despite Alice's best efforts, Finally, Alice reaches a holographic device left by the Red Queen who projects a recording of an Umbrella High Command meeting where Isaacs proposed using the T-virus to end the world while protecting the chosen few. The Red Queen explains that Isaacs' plan creates a conflict between her programing to follow all Umbrella orders and to protect human life. She wishes to prevent Isaacs plan from succeeding, but another directive prevents the Red Queen from harming any Umbrella employee. Through an earpiece, the Red Queen warns Alice that there is an Umbrella mole within her team.

Making their way through the Hive's vent system, guided by a holographic map on the Red Queen's device, Alice's group is forcibly separated and Alice ends up alone with Michael who is killed by a Licker-like creature. After a fight, Alice ensnares the creature with a chain then kills it with a knife through the brain. She meets up with Doc and they continue their way through the Hive, eventually reaching the laser corridor where so many of James Shade's Sanitation team lost their lives. Alice finds some of the Sanitation team's old equipment at the end of the corridor and arms herself and Doc with better weapons from their bags. Alice then activates an elevator which lowers them into the Hive where they spot stasis chambers containing thousands of Umbrella personnel and the entire Umbrella High Command. Alice and Doc then plant the Sanitation team's explosives on the stasis chambers to destroy the Hive and those within.

Reaching the bottom of the Hive, Alice is confronted by the real Doctor Alexander Isaacs who reveals that the one she encountered before was yet another clone. Isaacs threatens to destroy the anti-virus, forcing Alice to disarm herself and is amused by her attempts to find a suitable weapon from the instruments in the room. Doc then reveals himself as the Umbrella mole. To Alice's shock, she is revealed to be a clone herself, of Alicia Marcus, the daughter of Umbrella co-founder Doctor James Marcus. As time runs out for humanity, Alicia fires Wesker, enabling the Red Queen to drop a blast door on his arm, crushing it and trapping Wesker. As Isaacs' flees with the anti-virus, Alice reveals she had figured out Doc was the mole due to his survival and hands him over to Claire to kill. She then leaves the detonator for the explosives in Wesker's hand so that when he bleeds to death, the Hive will be destroyed. Alice is urged by Alicia and the Red Queen to chase after Isaacs' as he only has to evade her long enough for the last human settlement to be destroyed to win. Though Claire, Alicia and the Red Queen all warn Alice she will die as well due to the T-virus inside herself, she is determined to end things.

Making their way through the Hive, Alice and Claire confront Isaacs in the elevator to the surface. Aided by technological upgrades, Isaacs is able to evade all of their attacks. Alice ends up fighting Isaacs in the laser corridor, evading the lasers, but unable to defeat Isaacs who easily tosses her around. Finally, Isaacs cuts off the fingers of Alice's left hand with the lasers, but Alice uses the opportunity to drop an activated grenade in his pocket, apparently killing Isaacs. Retrieving the anti-virus, Alice is ordered by Claire to return to the surface alone as time is very nearly up. Alice makes it to the surface just before the Hive is destroyed by the explosives, killing the Umbrella High Commnad, Albert Wesker and Alicia Marcus.

On the surface, Alice drops the anti-virus only to have it caught by Isaacs' who survived due to a life support system installed within himself. As Isaacs holds Alice at gunpoint, they are interrupted by the Isaacs' clone Alice had fought earlier who arrives with an Undead army to stop her. The Isaacs clone is shocked to see his real self and refuses to believe that he is a clone. The Isaacs clone kills the real Isaacs before falling to the Undead. Alice retrieves the anti-virus and with an Undead army closing upon her, drops the anti-virus to the ground, shattering the capsule and releasing the anti-virus. Alice watches as the anti-virus quickly spreads through the Undead army, instantly killing them all upon contact, before collapsing herself from the effects of the anti-virus.

The morning after releasing the anti-virus, Alice awakens to Claire Redfield standing over her. Alice is shocked to have survived and reactivates the Red Queen's device to get answers from the AI. The Red Queen explains that the anti-virus destroyed Alice's infected cells, but her healthy cells survived and so did she. Alice questions why the Red Queen and Alicia Marcus had told her she would die and is informed they had wanted to see if Alice would be willing to sacrifice herself, something no Umbrella employee or creation would have ever done. The Red Queen tells Alice that she did it: the anti-virus destroyed the Undead army approaching the last human settlement while Isaacs' death enabled the Red Queen to reactivate herself and recall the attacking Umbrella forces. The Red Queen then informs Alice that before dying, Alicia uploaded her memories of her childhood into the AI who displays them for Alice so she will now have those memories as well. Thus, Alice has the opportunity to become the woman Alicia Marcus could've been had it not been for her fatal disease.

After getting Alicia's memories, Alice departs on an Umbrella motorcycle, knowing that the anti-virus could take several years to spread to all corners of the globe and thus Alice's mission to protect humanity is not yet over. As Alice drives away, three Kipepeo chase her and she smiles.

After Alice's exposure to the T-virus, via experimentation conducted by the Umbrella Corporation, the virus somehow bonded with her in a way that was not seen in others who were infected. In short, she gains all of the T-virus' "positive" effects and none of its negative effects like the deceasing of higher brain function, cannibalistic cravings, and eventual decomposing or rotting flesh. Alice was able to maintain her humanity and a strong sense of confidence in her skills as an advantage against even the most superior foes. In turn, the virus gave her enhanced strength, resilience, agility, reflexes, and accelerated healing and recovery. A display of her physical abilities is demonstrated in a duel in Apocalypse where she was able to overcome the latest B.O.W., the Nemesis (Matt Addison). She is also able to dispatch most human foes with ease, such during her time with the psychopaths in Extinction, she killed one of them with a single kick to the face, which presumably snapped his neck. She was durable enough to be barely affected when being tasered and regained full use of her finger after snapping it back into place.

By the end of Apocalypse, she develops telekinetic abilities by added experimentation. While escaping from the Umbrella Detroit facility, her telekinetic abilities were displayed when she caused a guard watching her from a surveillance room to bleed from every orifice, killing him slowly, after making her face appear on every screen in the room. It is possible that her ability to project her face on the screens is somehow related to Isaacs having developed a way to control her via satellite, suggesting she gained some form of interface with technology. Alice's telekinetic abilities were used four times in Extinction, first to levitate her motorbike (and several rocks) while dreaming, then to deflect the fire used to kill the crows, then to frying an Umbrella satellite's processor as it tried to control her and lastly to deflect a mutated Dr. Isaacs with a shockwave-like blast, stopping his tentacles and blowing him across the room and through a wall. The blast was powerful enough to destroy most of the corridor of the mansion similarly to an explosion. Use of her psychic abilities can cause her head pain or even render her unconscious, resulting in them rarely being used in battle. Also, the White Queen was able to detect "psionic activity" in the form of alpha and beta waves whenever Alice used her powers.

In Resident Evil: Afterlife, Alice's clones were shown to possess telekinesis and could use it on the same level she could, with one of them being able to destroy an entire room with a shockwave blast. They also displayed signs of Alice's heightened speed and agility, as they fought Wesker's men and guards. As Alice confronts Wesker on a chopper after he has blown up his facility, he injects her with a serum that destroys the T-cells in her body from the virus and thus renders her powerless. Alice actually thanks Wesker for this as it allows her to become a normal human again. Even without her powers, Alice retains the same level of confidence and fighting skills as she possessed with them before when she was a security operative of the Hive, and is even able to defeat an empowered Wesker (who had similar powers to her own) without her powers, using her own cunning and skill. In Resident Evil: Retribution she is able to defeat the empowered Rain without her powers as well through sheer ingenuity.

She is also a skilled combatant, being able to fight even with her hands bound. An example of her hand-to-hand combat prowess is shown when Bennett holds her at gunpoint, then she quickly disarms and kicks him. Alice is skilled with various forms of weaponry and is able to improvise weapons from random debris. In Afterlife, for instance, Alice wields a pair of sawed-off shotguns that fire custom "coin-shot" ammunition. Alice was capable of holding her own against various bioweapons. She has a superb level of precision and accuracy that surpasses others in the series. In Afterlife, she was able to shoot and hit two of the undead while in midair. While running, she accurately shot multiple moving undead targets in the head. During a confrontation with Wesker, she slams a surgical table then kicked a scalpel tray towards him in midair. Alice also displays a level of marksmanship superior to that of Wesker. In the Final chapter, while suspended in the air by a rope trap, she was able to hold her own and kill multiple Umbrella operatives.

However, during her battle with Isaacs she was only able to win with the help of one of her clones. Alice tricked Isaacs into a laser security system which she knew could kill Isaacs (even with his enhanced regenerative capabilities, faster than her own). If not for her clone deactivating the system on time Alice would have shared the same fate as Isaacs. This still shows her cleverness and courage in battle, a trait that has kept her alive in her battles.

At the end of Resident Evil: Retribution, Albert Wesker injects Alice with the T-Virus, instantly restoring her powers, which she threatened to kill him for. In The Final Chapter, while Alice has the T-virus inside of her, she displays none of her former powers. The Red Queen states that Wesker only pretended to restore her powers. All of her T-virus cells and any abilities they may have granted her are eradicated by the anti-virus at the end of The Final Chapter.

Alice wears a red dress, which has a plunging v neckline and thin straps. The left side of the dress is cut to hip level and the right side falls to below the knee. The dress is lined with a matching red fabric. Underneath, Alice wears a small black mini skirt and flat, black, three-quarter knee length boots complete the outfit. At times in the film she also wears a man's black leather biker jacket. Alice's hair is cut in a rough style to just above her shoulders and is parted at the side and layered.

Alice wears a cropped orange tank with spaghetti straps. Over her orange tank she has a tattered olive mesh tank, sleeveless, with a scooped neckline. The mesh tank comes down to the level of a short mini skirt. She wears dark grey/faded black jeans, bootcut and hipster style. Earlier in the film her pants are complete, but they get ripped. Once ripped, the middle part of her left trouser leg is missing, from above her leg holsters to below her knee. Her boots are dark leather and cowboy style, with a small heel. She wears many different holsters, including a webbed belt with double strapped leg holsters. She also has twin shoulder holsters and a leather strap slung across her chest for her shotgun. Her hair is dirty blonde and roughly cut to just above her shoulders and is center parted.

Alice wears a sand colored tank top, probably with spaghetti straps. Over this she wears a short sleeved brown shirt, with only a few buttons done up at the bottom. She also wears brown full chaps with stocking-style straps at the front, which appear to be part of her shirt, as well as short olive/stone cotton cut-off shorts. Her olive/stone twin leg holsters are held with waist straps that cross over at the back. At times she wears a dark scarf and fingerless gloves. She also has a full length, light brown duster coat. Her hair is dirty blonde and messy.

Alice, and her clones, wear a combat suit that is all black and contains a body suit. After her clones are blown up and she goes on a voyage she wears a large green coat that covers her brown leather black short-sleeved T-shirt, black military corset/vest, pair of black leggings, pair of green leg warmers, and pair of black boots. Alice has hair dyed dark brown and lets her natural hair color grow out.

Alice wears her Afterlife outfit in the first part of the movie. Her clone is seen wearing a red and white plaid shirt and blue skinny jeans, with brown boots. She wears a medical sheet when she wakes in Umbrella Prime. During the reboot of the Red Queen, she is given an Umbrella combat suit. The suit contains a black spandex full body suit, and cut-off finger gloves, sealed with finger seams. On the top of the suit is a tight, bustier-cut leather vest with buckles and the Umbrella logo. She wears black high boots with wedge heels. Her hair is neat and a darker shade of brown.

Alice wears a tattered green army jacket with the US flag on the left sleeve. She also wears a navy blue crop top, black denim demobraza jeans, black shiny lace-up boots, and black fingerless patted fingerless gloves. In addition she wears a dark gray/green camo vest harness that buckles to two leg holsters, and has cross straps on the top. Her hair is a brunette color with the front combed back on both side.

Early drafts of Extinction (then called "Afterlife") reveal Alice's real name to be Janice Prospero. This was also shown briefly in the lab scene at the end of Apocalypse, albeit spelt "Janus".

Throughout the course of the films, Alice's hair color gradually changes from blonde to brunette. According to Milla Jovovich via twitter Alice's natural hair colour is brunette and that she dyed it blonde prior to the events of the first film.

Alice's costume from the third film was designed by Milla Jovovich's clothing line, Jovovich-Hawk. Jovovich had a lot of influence in the costumes of the series after the first film.