Trial Information

Evaluating the Expression Levels of microRNA-10b in Patients With Gliomas

Inclusion Criteria

Inclusion/Exclusion Criteria:

- 18 years of age

- Brain tumor(s) to be resected for clinical reasons.

- Histological pathology confirmation that tumor is of glial origin, WHO Grade II, III
or IV.

- Adequate tissue available for processing as determined by Pathology.

- Adequate decision making ability to review, discuss and sign a consent form to allow
their tumor samples to be used for future human brain tumor biology laboratory
research. Determination of capacity to consent is made by one of the co-investigators
based on clinical assessment.

- Patients opting for the standard treatment regimen for their disease as well as
ongoing clinical trials will be are eligible to participate in this study. Standard
care for newly-diagnosed glioblastomas typically consists of surgical resection
followed by radiotherapy with concomitant temozolomide, followed by adjuvant
temozolomide chemotherapy.

Type of Study:

Observational

Study Design:

Observational Model: Cohort, Time Perspective: Prospective

Outcome Measure:

Overall Survival

Outcome Description:

Patients will be followed for survival every 12 weeks +/- 1 week.

Outcome Time Frame:

24 months

Safety Issue:

No

Principal Investigator

Arti B Gaur, PhD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Dartmouth-Hitchcock Medical Center

Authority:

United States: Institutional Review Board

Study ID:

D12160

NCT ID:

NCT01849952

Start Date:

May 2013

Completion Date:

December 2015

Related Keywords:

Astrocytoma

Oligodendroglioma

Oligoastrocytoma

Anaplastic Astrocytoma

Anaplastic Oligodendroglioma

Anaplastic Oligoastrocytoma

Glioblastoma

Brain Tumors

Brain Cancer

glioblastoma

miRNA

GBM

astrocytoma

Astrocytoma

Brain Neoplasms

Glioblastoma

Oligodendroglioma

Name

Location

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