PAIN IN EXTREMITY and Neurontin

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PAIN IN EXTREMITY Symptoms and Causes

Deep vein thrombosis, or DVT, is a blood clot that forms in a vein deep in the body. Most deep vein clots occur in the lower leg or thigh. If the vein swells, the condition is called thrombophlebitis. A deep vein thrombosis can break loose and cause a serious problem in the lung, called a pulmonary embolism.

Sitting still for a long time can make you more likely to get a DVT. Some medicines and disorders that increase your risk for blood clots can also lead to DVTs. Common symptoms are

Warmth and tenderness over the vein

Pain or swelling in the part of the body affected

Skin redness

Treatment includes medicines to ease pain and inflammation, break up clots and keep new clots from forming. Keeping the affected area raised and applying moist heat can also help. If you are taking a long car or plane trip, take a break, walk or stretch your legs and drink plenty of liquids.

PAIN IN EXTREMITY Clinical Trials and Studies

Treatments might be new drugs or new combinations of drugs, new surgical procedures or devices, or new ways to use existing treatments. The goal of clinical trials is to determine if a new test or treatment works and is safe. Clinical trials can also look at other aspects of care, such as improving the quality of life for people with chronic illnesses. People participate in clinical trials for a variety of reasons. Healthy volunteers say they participate to help others and to contribute to moving science forward. Participants with an illness or disease also participate to help others, but also to possibly receive the newest treatment and to have the additional care and attention from the clinical trial staff.

Symptom relief for chronic irritability in neurologically impaired children using gabapentin.; Prevalence of associated gastrointestinal and sleep problems in neurologically impaired children and improvement using gabapentin.

Difference in pain control when adding gabapentin to a multimodal pain management protocol in pediatric post-operative posterior spinal fusion patients.; Determine if opiate usage is less in the gabapentin group versus control.

Changes in quality of life; compare toxicity rates between the gabapentin and venlafaxine treatment groups; Assess changes in the hot flash scores for the two arms; Assess changes in quality of life using the Hot flash related Daily Interference Scale (HFRDIS)

The primary outcome measure of this project are to test the prediction that pain from tampon insertion is lower in PVD patients when treated with gabapentin compared to when treated with placebo.; The secondary outcome measure is to perform a mechanism-based analysis of gabapentin effectiveness, and to gain insight into the underlying pathophysiology of subtypes of PVD that may lead to more specific treatment options.

The primary outcome will be the adequacy of symptom control during the last week of the study.; Secondary outcomes equate dyspepsia symptoms with quality of life. The Nepean Dyspepsia Index scores patients on five categories while the Global Overall Symptom Scale measures the severity of dyspepsia on a 1-7 scale.

improvement of symptom domain means decreased frequency to less than 8 micturitions per 24 hours, no urgency noted per 24 hrs and less that 3 wakening at bedtime for micturation.; Improvement of bladder function domain means increased bladder capacity and decreased overactive detrusor as recorded in urodynamic study.; Improvement in quality of life domain means increased overall quality of life as perceived and result in OAB-q

Postoperative Pain using a Verbal Rating Scale (VRS); Opioid consumption obtained from the recorded data; postoperative nausea and vomiting using a Verbal Rating Scale; return to normal activities of daily living using follow up questionnaires; Patient satisfaction using a verbal rating scale from 0 to 100

If you think you may have a medical emergency, call your doctor or 911 immediately.

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