STRING allows inspection of the interaction evidence for any given network. Choose any of the viewers above (disabled if not applicable in your network).

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:query proteins and first shell of interactors

white nodes:second shell of interactors

Node Content

empty nodes:proteins of unknown 3D structure

filled nodes:some 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

argB

Acetylglutamate kinase (294 aa)

Predicted Functional Partners:

argC

N-acetyl-gamma-glutamyl-phosphate reductase (350 aa)

0.999

argJ

Bifunctional ornithine acetyltransferase/N-acetylglutamate synthase protein; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis- the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (410 aa)

0.995

argD

Acetylornithine aminotransferase (392 aa)

0.988

argA

XRE family transcriptional regulator (476 aa)

0.978

argF

Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline (306 aa)

a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1

node2

node1 accession

node2 accession

node1 annotation

node2 annotation

score

Mfla_2256

Mfla_2257

Mfla_2256

Mfla_2257

Pyrimidine 5-nucleotidase

Nucleoid occlusion protein

0.883

Mfla_2256

argB

Mfla_2256

Mfla_2255

Pyrimidine 5-nucleotidase

Acetylglutamate kinase

0.852

Mfla_2257

Mfla_2256

Mfla_2257

Mfla_2256

Nucleoid occlusion protein

Pyrimidine 5-nucleotidase

0.883

Mfla_2257

argB

Mfla_2257

Mfla_2255

Nucleoid occlusion protein

Acetylglutamate kinase

0.852

Mfla_2734

argA

Mfla_2734

Mfla_2252

Glutamate synthase (NADPH)

XRE family transcriptional regulator

0.966

Mfla_2734

argB

Mfla_2734

Mfla_2255

Glutamate synthase (NADPH)

Acetylglutamate kinase

0.941

Mfla_2734

argD

Mfla_2734

Mfla_1710

Glutamate synthase (NADPH)

Acetylornithine aminotransferase

0.950

Mfla_2734

argF

Mfla_2734

Mfla_1709

Glutamate synthase (NADPH)

Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline

0.505

Mfla_2734

argG

Mfla_2734

Mfla_1708

Glutamate synthase (NADPH)

Argininosuccinate synthase

0.977

Mfla_2734

argH

Mfla_2734

Mfla_0038

Glutamate synthase (NADPH)

Argininosuccinate lyase

0.788

argA

Mfla_2734

Mfla_2252

Mfla_2734

XRE family transcriptional regulator

Glutamate synthase (NADPH)

0.966

argA

argB

Mfla_2252

Mfla_2255

XRE family transcriptional regulator

Acetylglutamate kinase

0.978

argA

argC

Mfla_2252

Mfla_0057

XRE family transcriptional regulator

N-acetyl-gamma-glutamyl-phosphate reductase

0.988

argA

argD

Mfla_2252

Mfla_1710

XRE family transcriptional regulator

Acetylornithine aminotransferase

0.955

argA

argF

Mfla_2252

Mfla_1709

XRE family transcriptional regulator

Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline

0.976

argA

argG

Mfla_2252

Mfla_1708

XRE family transcriptional regulator

Argininosuccinate synthase

0.998

argA

argH

Mfla_2252

Mfla_0038

XRE family transcriptional regulator

Argininosuccinate lyase

0.967

argA

argJ

Mfla_2252

Mfla_2232

XRE family transcriptional regulator

Bifunctional ornithine acetyltransferase/N-acetylglutamate synthase protein; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis- the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate

0.989

argB

Mfla_2256

Mfla_2255

Mfla_2256

Acetylglutamate kinase

Pyrimidine 5-nucleotidase

0.852

argB

Mfla_2257

Mfla_2255

Mfla_2257

Acetylglutamate kinase

Nucleoid occlusion protein

0.852

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Network Stats

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Functional enrichments in your networkNote: some enrichments may be expected here (why?)

Enrichment analysis is still ongoing, please wait ...

Statistical background

For the above enrichment analysis, the following statistical background is assumed: