Data Catalog

Laboratory of Cell and Molecular Biology

The Laboratory of Cell and Molecular Biology investigates the
organization, compartmentalization, and biochemistry of eukaryotic
cells and the pathology associated with human disease.

Access & Use Information

Public: This dataset is intended for public access and use.License: No license information was provided. If this work was prepared by an officer or employee of the United States government as part of that person's official duties it is considered a U.S. Government Work.

The Laboratory uses molecular genetics and biochemical
approaches to understand the mechanisms underlying intracellular
trafficking of lipids, nuclear proteins, and other factors
regulating transcription, replication, and signal
transduction. Researchers in the Laboratory also explore the
fundamental processes involved in cell cycle control, genome
structure, and replication as well as the control of gene
expression. Other areas of scientific interest include the
glycobiology of development, stem cell biology, and
epigenetics. Specific projects focus on a range of topics,
including (1) the nuclear transport of transcription factors,
nuclear kinases, steroid hormone receptors, and replication factors
that serve a critical regulatory function; (2) the initial events
of steroid hormone action, with an emphasis on glucocorticoid
receptors; (3) the molecular mechanisms of insulin resistance and
glucose-sensing in the pancreas (as part of type 1 and type 2
diabetes); (4) the causes and consequences of repeat expansion in
Fragile X syndrome and Friedreich&#39;s ataxia; and (5) the role of
O-linked N-acetylglucosamine (O-linked GlcNAc) and its enzymes in
diabetes.