Chemical structure

Protocol

Cell experiment [1]:

Cell lines

COLO-320DM cells lines

Preparation method

The solubility of this compound in DMSO is >26.5mg/mL. General tips for obtaining a higher concentration: Please warm the tube at 37℃ for 10 minutes and/or shake it in the ultrasonic bath for a while. Stock solution can be stored below -20℃ for several months.

Reacting condition

0.2 μmol/L for 7 to 13 days

Applications

G007-LK inhibits cell-cycle progression, reduces colony formation, and induces differentiation, suggesting that b-catenin–dependent maintenance of an undifferentiated state may be blocked by tankyrase inhibition.