NON-TECHNICAL SUMMARY: General methods to produce uniform capsules with well-defined and controllable shell thickness and diameter, especially at the nano- and micro-scale, are in great demand for controlled and timed release of drugs, agrochemicals, nutraceuticals, and probiotics. The proposed… More

DESCRIPTION: Novel continuous, non-woven oxide nanofibers will be used to design, produce and test a new class of allceramic materials for restorative Dental applications. The working hypothesis is that these new nanofiber/glass systems will be of significantly higher mechanical quality than… More

Micro- and nano-encapsulation (one nanometer = 0.000000001 meter) of food additives is an active R&D area. The release characteristics and protective properties of the encapsulant need to be tailored to specific industrial needs on a case-by-case basis. Nanotechnoly strategies as the one proposed in… More

This Small Business Innovation Research (SBIR) Phase I project is a feasibility study to produce two-submicron inorganic powders via solvent-free processing routes. One of the materials is the anionic clay known as hydrotalcite, which is used as an antacid and a PVC additive. The other material is… More

DESCRIPTION (provided by applicant): This Phase I SBIR program is aimed at initiating a business venture dedicated to the manufacturing of nanoparticulates for toxicology research. The rate of nanotechnology R&D growth in the commercial, academic, and private sectors, appears to be outpaced only by… More

The commercial opportunities for products based on delicate biomolecules, such as enzymes and therapeutic proteins, are growing at a strong pace. However, many proteins of great commercial value, including enzymes, undergo loss of function on encapsulation, when approaches based on high-shear… More

This Small Business Innovation Research (SBIR) Phase I project will explore the use of a material comprising a fibrous substrate and an inorganic adsorbent/catalytic coating for removal of toxic small linear molecules from smoke. Phase I research will focus on identification of an efficient… More

This Small Business Technology Transfer (STTR) Phase I project is a feasibility study for the design of true core-shell type nonocapsules for drug delivery. The research will focus on strategies aimed at controlling the nanostructure and chemistry of the capsules, and also on ways to design… More

DESCRIPTION (provided by applicant): LNK Chemsolutions LLC collaborates with researchers from the University of Chicago to develop nanocapsule technology for enhanced delivery to gliomas. Preliminary results are particularly encouraging in that the nanocap
sules display very good transport in… More

DESCRIPTION (provided by applicant): A multidisciplinary team of researchers seeks to develop novel and economically feasible implantable hemostatic dressings for severe (e.g. arterial) bleeding. Key features of the device under development are its excelle
nt pliability, biocompatibility, and… More

In general, many biological and chemical agents affect the lungs directly or indirectly, even if the respiratory system is not the primary target organ of a military or terrorist attack. Both in the case of military and civilian attacks the lung can be one of the first organs affected by a chemical… More

DESCRIPTION (provided by applicant): Malignant gliomas represent a heterogeneous family of tumors that are poorly responsive to current treatments. A major obstacle to the effective management of these lesions involves the difficulty in delivering adequateconcentrations of therapeutics to the tumor… More

DESCRIPTION: The goal of the proposed project is to develop a biocompatible ultrafine particle-based vector system for the intranasal delivery of clozapine for the pharmacological therapy of treatment- resistant schizophrenic disorders and their associatedsuicidal behavior. The rationale behind the… More