After saving Kinzie Kensington from the Deckers, she directs The Protagonist and Pierce towards Safeword to rescue Zimos. Kinzie explains that all prostitution in Steelport is controlled by the DeWynter twin sisters, Viola and Kiki, and Zimos is locked up in Safeword for competing with them.[2] The Protagonist and Pierce manage to fight their way through the brothel to Zimos, who is locked up in the basement, and escape with him via Pony Cart.[1]

The Protagonist and Zimos later return to Safeword; Zimos auctions off The Protagonist as a sex slave to infiltrate the brothel.[3] After a naked Protagonist wakes up from being drugged, the two fight their way through the brothel's basement, freeing prostitutes as they go. After killing a Brute clad in heavy armor and wielding a Mini-Gun in the garage, The Protagonist and Zimos finally clear out Morningstar from Safeword and claim it as their own.[4]

Although the dialogue differs depending on which voice is chosen in Player Customization, the conversation between The Protagonist and Pierce while driving to Safeword in "Return to Steelport" implies that Pierce has been to a BDSM club before, although he does not indicate whether or not he had been to Safeword.

Safeword cannot normally be entered, as the front door is not able to be opened, but it is possible to the Genki Manapult to get inside, or to summon the Sonic Boom with a cheat and blast the doors open.

While looking for Zimos during Return to Steelport, some doors are locked, but immediately after rescuing Zimos the doors all doors are unlocked, allowing the interior to be fully explored.

Zimos: "That's an invitation to kick the Morningstar right in their collective pussy. They're having an auction tonight--flash the card, and you're in."The Protagonist: "So what, I pretend to be an eccentric millionaire?"Zimos: "Kind of. I'm gonna auction you off as a sex slave."