Novel antibiotic combinations against infections with almost completely resistant Pseudomonas aeruginosa and Acinetobacter species

James J RahalInfectious Disease Section and Lang Research Center, New York Hospital Queens, and Department of Medicine, Weill College of Medicine, Cornell University, New York, New York 11355 5095, USAClin Infect Dis 43:S95-9. 2006

The role of carbapenems in initial therapy for serious Gram-negative infections

..Thus, doripenem may be valuable alone or in combination with other agents in the treatment of serious gram-negative infections...

Novel antibiotic combinations against infections with almost completely resistant Pseudomonas aeruginosa and Acinetobacter species

James J RahalInfectious Disease Section and Lang Research Center, New York Hospital Queens, and Department of Medicine, Weill College of Medicine, Cornell University, New York, New York 11355 5095, USAClin Infect Dis 43:S95-9. 2006

..However, against infections with species resistant to all antibiotics, including polymyxins, novel combinations are the only remaining therapeutic option...

The role of carbapenems in initial therapy for serious Gram-negative infections

..Early initiation of IFN-alpha2b therapy may reduce the severity and duration of complications due to previously untreatable flavivirus meningoencephalitis. A prospective randomized controlled trial is warranted...

..CTX-M beta-lactamases have emerged within our location, and detection of bacteria harboring these enzymes in the clinical microbiology laboratory remains problematic because molecular methods are needed for their identification...

Identification of CTX-M β-lactamases among Escherichia coli from the community in New York City

..Patients with symptomatic bacteriuria received drugs to which the organisms were susceptible, and most had favorable outcomes. Timely recognition of such isolates could help physicians choose more appropriate antibacterial therapy...

..Published clinical results of therapy with these agents are reviewed, and in vitro evidence of synergy between them is presented that suggests that combination therapy should be studied for enhanced clinical activity...

..Future clinical studies using double and triple therapy with these antibacterials may provide an effective option against potentially lethal infection due to multiresistant Acinetobacter baumannii...

..pneumoniae due to KPC enzymes can only be achieved by molecular methods, detection in the Clinical Microbiology Laboratory by routine methods will continue to be difficult, leading to dilemmas in treatment...