HUGO MOSER RESEARCH INSTITUTE OVERVIEW

Kennedy Krieger’s scientists and researchers are leaders in the worldwide effort to prevent and treat disorders of the brain, spinal cord, and musculoskeletal system. Our investigators continue to break new ground with innovative magnetic resonance imaging technology, investigate critical areas, such as the role of genetics in developmental disorders, and develop new treatment models and therapies. Kennedy Krieger is committed to sharing our knowledge that can be adapted and used by other healthcare organizations to benefit patients across the country and around the world.

Learn more about the Hugo Moser Research Institute's innovative research initiatives and latest findings:

Professional Training Overview

Kennedy Krieger dedicates substantial resources to increasing the number of qualified specialists in the fields of neurological and developmental disabilities. We also take seriously our responsibility not only to improve care through research, but to share that knowledge with others. That is why more than 400 individuals come here to train in a wide variety of disciplines each year. The goals of the Institute’s clinical training programs are twofold: 1) to train leaders in the field of neurodevelopmental disabilities and 2) to help ensure that there is a sufficient number of qualified professionals to meet the needs of children with special health care needs and their families. By training future generations of researchers and professionals – from undergraduate students to current staff – we are ensuring that children everywhere can receive the best possible care.

The Interactive Autism Network (IAN) is the nation's largest online autism research effort. IAN Research collects data from families online and matches them to studies nationwide.

HUGO MOSER RESEARCH INSTITUTE OVERVIEW

Kennedy Krieger’s scientists and researchers are leaders in the worldwide effort to prevent and treat disorders of the brain, spinal cord, and musculoskeletal system. Our investigators continue to break new ground with innovative magnetic resonance imaging technology, investigate critical areas, such as the role of genetics in developmental disorders, and develop new treatment models and therapies. Kennedy Krieger is committed to sharing our knowledge that can be adapted and used by other healthcare organizations to benefit patients across the country and around the world.

Learn more about the Hugo Moser Research Institute's innovative research initiatives and latest findings:

Participate in Research

Over the years, Kennedy Krieger’s scientists and researchers have made crucial medical discoveries that have led to innovative treatments and improved patient care for individuals with disorders of the brain, spinal cord and musculoskeletal system. Learn more about current research studies you can participate in by visiting our recruiting research studies page. View studies

CLINICAL TRIALS STUDIES

The Clinical Trials Unit at Kennedy Krieger Institute brings together patients and families, research scientists and private industry to unlock the potential of new treatments to treat, cure and prevent genetic and developmental disorders. Learn more

Current Research Projects

Sponsored by the National Institutes of Health -- 2R01HD040289.
Cerebellar damage disrupts movement coordination. Actions ranging from walking to reaching become inaccurate and difficult to control,...

Sponsored by DHHS/CDC -- 1U50MN000025.
Healthy People 2020 highlights the importance of eliminating health disparities and increasing the quality and years of healthy life free of preventable disease...

A 12 Week Double Blind Placebo Clinical Trial to Evaluate the Safety and Efficacy of Rivastigimine in Children with Down Syndrome

Principal Investigator: Capone, George

Individuals with Down syndrome (DS) exhibit a notable cholinergic deficiency by the 4th decade of life. It is unclear how early in life presynaptic cholinergic deterioration begins or how it evolves...

Assessments of severe behavior disorders of children with intellectual and developmental disabilities (IDD) have revealed that behavior problems are often maintained by their functional outcomes (or...

Sponsored by the National Institutes of Health -- 1K23NS073626-01.
There are substantial data to suggest that altered cerebral connectivity is a key aspect of the neurobiology of autism. Nevertheless...

An adaptive, phase IIB/III, double-blind, randomized, placebo-controlled, multi-center study of the safety and efficacy of NaBen® (sodium benzoate), a d-amino acid oxidase inhibitor, as an add-on treatment for schizophrenia in adolescents

Principal Investigator: Findling, Robert

Phase IIb Objectives: The primary objective of the Phase IIb portion of this study is to evaluate NaBen® (sodium benzoate) (1000 mg/day) safety and effectiveness and to determine the final sample...

Sponsored by the National Institute of Arthritis and Musculoskeletal and Skin Disease -- 1R01AR062074-04
The overall goal of this project is to investigate the role of the myostatin/activin signaling...

The purpose of this research is to assess the growth parameters(height and weight) in osteogenesis imperfecta during infancy, childhood, and adolescence with the ultimate goal of determining whether...

Problem Sleep in Children and Young Adults with Fragile X Syndrome with and without Autism Spectrum Disorder

Principal Investigator: Accardo, Jennifer

This study will examine relationships between sleep difficulty and autism in boys and young men with full mutation Fragile X syndrome (FXS). This study will analyze retrospective cross-sectional data...

Sleep disturbances in neurobehaviorally challenged children with sickle cell disease: A pilot study

Principal Investigator: Accardo, Jennifer

This study aims to evaluate sleep in a sample of children, adolescents, and young adults with SCD referred for neurobehavioral evaluation for academic and cognitive difficulties. We will further test...

Use of an Educational Story to Prepare Children with Developmental Disabilities for Overnight Polysomnography

Principal Investigator: Accardo, Jennifer

We hypothesize that use of an educational story with pictures illustrating overnight polysomnography procedure accompanied by simple narrative will be a cost-effective, readily accepted intervention...

Children have a high prevalence of sleep problems and disorders. The current study will be a retrospective record review of clinic records from a subspecialty sleep medicine clinic staffed by a child...

Study of the Relationship Between Preferences for High Fat Food Items and Ketogenic and Modified Atkins Diet Efficacy Among Children with Seizure Disorders

Principal Investigator: Amari, Adrianna

Although highly effective for the treatment of intractable epilepsy, the ketogenic diet is not always included in the treatment option hierarchy presented to families, in part due to perceptions that...

What are the descriptive and clinical outcomes of 25 children treated at KKFC? Child-Caregiver dyads treated at KKFC will be assessed at baseline, three-months, six-months, nine-months and 12-months...

The KIDnet system is a clinical needs assessment, functional outcome measure, and therapeutic effectiveness database used by the State of Maryland and clinical foster care providers (Kennedy Krieger...

This study is an open trial to determine the effectiveness of the Strengthening Family Coping Resources (SFCR) clinical treatment for children and families affected by trauma exposure. The clinicians...

Leadership Behaviors of Health Professionals and the Associations with Knowledge, Attitudes, and Practices Related to Health Promotion for Individuals with Developmental Disabilities

Principal Investigator: Belcher, Harolyn

The study was completed under protocol: NA_00014866. There will be no change in questions, plan or new data collection. Reactivating study to analyze the data previously collected and for manuscript...

The Garden of Hope: Horticultural Therapy with Traumatized Children (HTTC) study will evaluate the effectiveness of horticultural therapy as an adjunct therapy to standard mental health treatment for...

This study is designed to evaluate the association between parental risk factors and child behavior and parental stress following six months of mental health treatment. The study will use data from a...

Preliminary data suggests that spinal cord and sensorimotor cortical function is disrupted following SCI and individuals with SCI have a different pattern of brain activation compared to individuals...

An Evaluation of Noncontingent Reinforcement and Differential Reinforcement with Escape Extinction in the Treatment of Food Refusal

Principal Investigator: Borrero, Carrie

This study is a retrospective record review of former patients on the Pediatric Feeding Disorder Unit at Kennedy Krieger Institute. The primary objective of this study is to compare effects of escape...

The Use of Video Modeling via an iPad to Increase Independence with Vocational Tasks for Students with Autism

Principal Investigator: Brandenburg, Linda

The purpose of this study is to employ a single-case reversal research design (ABAB) to evaluate the effectiveness of using video modeling procedures by means of an iPad to increase independent task...

Fragile X Clinical and Research Cooperative Consortium Registry and Repository

Principal Investigator: Budimirovic, Dejan

This project will advance the core activities of the Fragile X Clinical and Research Consortium (FXCRC). The FXCRC is a collaborative endeavor initiated in 2006 by the National Fragile X Foundation (...

This study is a de-identified retrospective review of previously collected clinical data. The aim of the study is to compare acquisition of early communication skills between individuals with fragile...

Cardiac arrest in childhood often results in death or poor quality neurologic survival. Out-of-hospital cardiac arrest in children is usually preceded by respiratory failure and hypoxia, whereas in-...

This 1 of three projects funded by a NIH consortium grant to study Sturge-Weber syndrome (SWS). It will create a national database, determine if urine biomarkers can predict neurologic progression in...

Assessments of severe behavior disorders of children with intellectual and developmental disabilities (IDD) have revealed that behavior problems are often maintained by their functional outcomes (or...