Abstract

After making model of gastric functional disorder (FD), part of model mice were injected
intravenously (i.v.) with oxide multi-walled carbon nanotubes (oMWCNTs) to investigate
effect of carbon nanotubes on gastric emptying. The results showed that NO content
in stomach, compared with model group, was decreased significantly and close to normal
level post-injection with oMWCNTs (500 and 800 μg/mouse). In contrast to FD or normal
groups, the content of acetylcholine (Ach) in stomach was increased obviously in injection
group with 500 or 800 μg/mouse of oMWCNTs. The kinetic curve of emptying was fitted
to calculate gastric motility factor k; the results showed that the k of injection group was much higher than FD and normal. In other words, the gastric
motility of FD mice was enhanced via injection with oMWCNTs. In certain dosage, oMWCNTs
could improve gastric emptying and motility.