Trump is bucking tradition by journeying away from North America for his first foreign trek; the past five presidents visited Canada or Mexico as their first venture abroad.

The president's first stop will be in Saudi Arabia, before continuing to Israel, Italy, Vatican City and Belgium. Along the way he will meet with King Salman of Saudi Arabia, Israeli Prime Minister Benjamin Netanyahu, Palestinian President Mahmoud Abbas, Pope Francis, Italian President Sergio Mattarella, King Philippe of Belgium and the leaders of the G7 countries, among others.

Earlier this month, an administration official portrayed the decision to first visit Saudi Arabia -- home to two of Islam's holiest sites, Mecca and Medina -- as symbolic.

"We thought that was very important because, obviously, people have tried to portray the president in a certain way, but I think that what he wants to do is solve the same problem that a lot of the leaders in the Islamic world want to do," a senior administration official told ABC News.

Pope Francis commented on Trump's visit last weekend, saying that he would not judge the controversial president despite having divergent views on a number of issues, including climate change and immigration.

"I will tell him what I think, he will tell me what he thinks, but I never wanted to judge someone before I listen to the person first," the pope said.

The trip will conclude with the president meeting NATO leaders and attending a G7 summit. Trump has previously met with all of the G7 leaders except French President Emmanuel Macron, who took office within the last week.

Trump tweeted this morning that the focus of his overseas trip would be on the U.S.

"Getting ready for my big foreign trip," wrote Trump. "Will be strongly protecting American interests - that's what I like to do!"

Getting ready for my big foreign trip. Will be strongly protecting American interests - that's what I like to do!

And first daughter Ivanka Trump, who is joining her father on the trip along with her husband Jared Kushner, posted a photo to her Instagram account of her and Kushner, writing, "Today we embark on this Administration's first foreign trip. I look forward to a historic and meaningful visit to the Middle East and the Vatican in promotion of religious tolerance globally."