Eric Kaplan's first television writing job was with Late Show with David Letterman which he worked on for a year and a half before quitting and moving to Hollywood to look for a job in "half-hour" work.[4] It was at this time that Kaplan learned of Matt Groening doing a show set in the year 3000. This show would turn out to be Futurama. After applying for work on the show using some writing samples, Eric would have to, as he says, "sweat it out", for over a month before getting the job. Upon Futurama's cancellation, Kaplan went to work for the short-lived comedy series Andy Richter Controls the Universe, writing just one episode. After Fox dropped Andy Richter, Eric Kaplan then began work on the hit show Malcolm in the Middle, Eric also wrote the "Girlfriends" episode of the popular HBO series, Flight of the Conchords.

In his first year with Futurama, which was also the show's first season, Kaplan served as story editor on every episode. Though having an input on many aspects of the entire first season, Kaplan would not get a writing credit until 9 episodes in. After this premiere season, he would be promoted to producer status. This was a role that he would keep through the show's end. He returned to those roles in the Futurama DVD movies.

In his two years as a writer on Malcolm in the Middle, Kaplan wrote four episodes while serving as supervising producer in the first half of the 5th season and co-executive producer throughout the rest of the series' run.

Zombie College was an internet web series Kaplan created that revolved around a student at a college full of zombies.

Kaplan described the premise of Zombie College as

the idea of the human ability to get used to practically anything. That there's nothing so horrible that we can't get used to it and accept it as part of life (...) Zombie College is an environment where there are undead monsters running around and trying to eat your brain but everybody is o.k. with it and they're more interested in getting good grades.[5]

Kaplan runs Mirari Films, an animation studio and VFX house. In addition to The Drinky Crow Show, Mirari Films produces Baxter and McGuire for Comedy Central and is developing shows with several artists in the fields of comedy and comics.