Browse our anti-TRF2 (TERF2) Antibodies

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anti-Telomeric Repeat Binding Factor 2 Antibodies (TERF2)

On www.antibodies-online.com are 72 Telomeric Repeat Binding Factor 2 (TERF2) Antibodies from 13 different suppliers available. Additionally we are shipping TRF2 Kits (10) and TRF2 Proteins (4) and many more products for this protein. A total of 93 TRF2 products are currently listed.

Study demonstrates that TRF2 interacts with and is sumoylated by PIAS1 (show PIAS1 Antibodies) and RNF4 (show RNF4 Antibodies) targets SUMO-conjugated TRF2 for ubiquitination, thereby decreasing its stability suggesting that TRF2 status provides a molecular switch that controls its level at telomeres.

TRF2 is a specific target of miR (show MLXIP Antibodies)-23a, and uncover a previously unknown role for miR (show MLXIP Antibodies)-23a in telomere regulation and cellular senescence

The variability of genes encoding for TERF1 (show TERF1 Antibodies) and TNKS2 (show TNKS2 Antibodies) is important for keeping the integrity of the telomere structure and show a significant association with longevity.

We concluded that genomic instability resulting from loss of TRF2 expression provides biological advantages to the cancer stem cell population

Conditional deletion of individual components of shelterin showed that TRF2 was required for the formation and/or maintenance of t-loops, whereas deletion of TRF1 (show TERF1 Antibodies), Rap1 (show TERF2IP Antibodies), or the POT1 (show POT1 Antibodies) proteins (POT1a (show POT1 Antibodies) and POT1b) had no effect on the frequency of t-loop occurrence.

TAF7L (show TAF7L Antibodies) associates with TRF2 both in vitro and in testis, suggesting that TAF7L (show TAF7L Antibodies) likely cooperates directly with TRF2 at promoters of a subset of postmeiotic genes to regulate spermiogenesis.

the molecular properties of TRF2 that are both necessary and sufficient to protect chromosome ends in mouse embryonic fibroblasts: the data support a two-step mechanism for TRF2-mediated end protection

TRF2 (TERF2) Antigen Profile

Antigen Summary

This gene encodes a telomere specific protein, TERF2, which is a component of the telomere nucleoprotein complex. This protein is present at telomeres in metaphase of the cell cycle, is a second negative regulator of telomere length and plays a key role in the protective activity of telomeres. While having similar telomere binding activity and domain organization, TERF2 differs from TERF1 in that its N terminus is basic rather than acidic.