PatientsVille.com

Fever | Oral Versus Rectal Ibuprofen for Fever in Young Children - a Randomized Control Study.

Fever research study

What is the primary objective of this study?

Fever is one of the most common symptoms in pediatrics and one of the most common reasons for
visits in pediatricians' office and pediatric emergency departments. Many parents consider
fever to be the most terrifying symptom.
Ibuprofen is an effective and safe treatment for febrile children. Until recently ibuprofen
was available only in tablets suspension and as a liquid gel. All these dosage form are
administered orally. Rectal suppositories are often essential for treating febrile children
who cannot take medications by mouth (e.g vomiting). In the current study we aim to compare
the effect on fever of ibuprofen given as suspension with ibuprofen suppositories.

Study Interventions

Interventions can include giving participants drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available or noninvasive approaches such as surveys, education, and interviews.

Drug:Ibuprofen suppository5-10mg/Kg of ibuprofen

Drug:Ibuprofen Suspension5-10mg/Kg

Study Arms

Research studies and clinical trials typically have two or more research arms. An arm is a group of people who receive the same treatment in the study.

1Ibuprofen Suppository

2Ibuprofen suspension

Study Status

Unknown status

Start Date: September 2008

Completed Date: June 2011

Phase: Phase 4

Type: Interventional

Design:

Primary Outcome: Maximal change in temperature during the 4-hour period after enrollment.

Secondary Outcome: Proportion of patients with a drop of at least 1°C and 2°C in mean temperature at 4h. Decrement in fever at each time point, and the area under the temperature (versus time) curve. Proportion of patients with temperature < 38 at 4 hours.

Study sponsors, principal investigator, and references

Principal Investigator:

Lead Sponsor: Assaf-Harofeh Medical Center

Collaborator:

More information:https://clinicaltrials.gov/show/NCT00729976

Discuss Pyrexia

If you think you may have a medical emergency, call your doctor or 911 immediately.

By accessing this website, you are indicating your acknowledgement and acceptance of these Terms of Use. These Terms of Use are subject to change by WinFirst LLC at any time in its discretion. Your use of WinFirst LLC Site after such changes are implemented constitutes your acknowledgement and acceptance of the changes. Please consult these Terms of Use regularly.
PatientsVille.com does not provide medical advice, diagnosis or treatment. The information contained on PatientsVille.com site has not been scientifically or otherwise verified as to a cause and effect relationship and cannot be used to estimate the incidence of adverse drug reactions or for establishing or changing of patient treatments.