New York's Victor Cruz suffered a concussion and knee sprain in the third quarter against the Seahawks. He was able to get up and walk off the field under his own power, but he will not return.

Cruz jumped and made a great catch on 3rd-and-long, but he was slammed to the ground as he came down, hitting his head on the turf.

It was another dismal day for Cruz (2-25, 7 targets) and the Giants, who were getting shut out at the time of his injury. There's no reason for him to rush back if he's suffering any concussion symptoms or problems with his knee, so his absence could extend into next week. Rueben Randle and Hakeem Nicks figure to see more targets, which could make both WR3s against Detroit in Week 16, but it's tough for fantasy owners to count on anyone in the Giants' offense, with the possible exception of Andre Brown. (UPDATE: According to the New York Daily News, Cruz is in danger of missing Weeks 16-17.)

Brown gets stung: Indianapolis' Donald Brown suffered a stinger in the second quarter against Houston and did not return, possibly because the Colts had a comfortable lead the majority of the game. He had shared carries equally with Trent Richardson up to that point but had outgained Richardson by 34 yards.

Richardson got the bulk of the RB touches after that. Daniel Herron Tashard Choice is the Colts' next-in-line. Given how uninspiring Richardson was before some late runs, there's a chance Choice could get playing time and be a legit flex back over the next two weeks. Richardson did manage a short TD on a shuffle pass, but he's still struggling running the ball.

Haden shut down: One of fantasy's most feared defensive players, Joe Haden, was sidelined because of a hip injury in the second half against the Bears. He did not return.

Haden's "shutdown" reputation had taken a hit over the past couple weeks, as WR1s Antonio Brown, Cecil Shorts III and Julian Edelman all scored against the Browns (and Brandon Marshall this week), but he's still a worry if your top receiver is facing him. The Browns play the Jets next week, so it might not matter to fantasy owners if Haden is out, but it could affect your D/ST play, as the Browns become less desirable without their top corner.

Painful win for Cardinals: The Cardinals won in overtime, but may have lost a few key players along the way. WR Larry Fitzgerald left with a concussion and reportedly wasn't feeling well after the game. He'll have to pass the NFL's concussion tests to play at Seattle, leaving his status in question. Michael Floyd could see extra targets if Fitz is out, but it's a very tough matchup.

Meanwhile, QB Carson Palmer suffered an ankle sprain in the win and needed a "heavy tape job" to finish the game. It's another reason to avoid Palmer (and Arizona's receivers) next week at Seattle.

Finally, Cardinals RB Andre Ellington said the thigh bruise that kept him out of overtime Sunday is not serious. But it was enough to keep him out of the most crucial part of the game and could be enough to limit his workload even more than usual next weekend.

Gresham goes down: Bengals TE Jermaine Gresham suffered a hip injury during the third quarter of Sunday night's loss at Pittsburgh and did not return. His status is unknown, but if he misses Week 16, rookie Tyler Eifert, who caught a TD after Gresham's departure, would see an increased role.

Tate a late injury addition: Texans RB Ben Tate re-injured his ribs Sunday and is undergoing tests this week. If Tate isn't able to suit up in Week 16, which is meaningless for the 2-12 Texas, Dennis Johnson would get the start against the Broncos.