The combination of lighting options possible with this product is particularly useful for observation of small objects where fine control of light direction, intensity, and distribution directly impacts observable surface features and object translucence.

This technology is available for licensing and a limited production run of commercial units is underway. Contact us if you are a microscopist, entomologist, archeologist, curator, or photographer interested in participating in testing this new product in your laboratory.

Performance quality of many industrial materials depends on consistent distribution of particle sizes within the material. The ability to quantify other parameters such as surface roughness, surface area, and particle shape is also desirable. Current methods provide a static, batched measurement of limited utility. This new method and device provides real-time measurements directly from the manufacturing line flow.

This device has demonstrated performance on paper additive products with aspect ratios ranging from 2 to 8 and short axis diameters between 100 and 500 nm. Applications are in quality control.

Raw DNA data is filtered with a multi-component analysis that is applied to the difference of the signal intensity on each of the raw DNA data signals to remove cross talk between the signals. The analysis is done before any baseline adjustment of the raw DNA data. Instead, the baseline adjustment occurs after the raw DNA data has been filtered. Additionally, an additional processing step is applied to the data to account for the non-linear nature of cross talk filtering. The additional processing step involves combining the signal with its derivative to account for the correlation of each of the data signals with the other three data signals.

A microscopy system is configured for creating 3D images from individually localized probe molecules. The microscopy system includes a sample stage, an activation light source, a readout light source, a beam splitting device, at least one camera, and a controller. The activation light source activates probes of at least one probe subset of photo-sensitive luminescent probes, and the readout light source causes luminescence light from the activated probes. The beam splitting device splits the luminescence light into at least two paths to create at least two detection planes that correspond to the same or different number of object planes of the sample. The camera detects simultaneously the at least two detection planes, the number of object planes being represented in the camera by the same number of recorded regions of interest. The controller is programmable to combine a signal from the regions of interest into a 3D data.

PROBLEM: 1.) Important science topics are sometimes not addressed in high schools because spectroscopy instruments are too expensive to purchase and maintain 2.) Field technicians have to take water and soil samples to a lab for spectroscopy analysis, adding time and complication 3.) Valuable data is not available from remote sensors due to spectrometer power and durability limitations.

SOLUTION: A portable, durable florescence spectrometer that costs 50% less than comparable instruments in most applications due to its novel design and simple components.