proviron steroid

Reducing the load on the heart leads to a decrease in myocardial oxygen demand. Secondly, under the action of the drug, due to expansion of the coronary arteries increasing the oxygen supply to the myocardium (especially with vasospastic angina). Amlodipine does not adversely affect the metabolism of lipids and blood plasma, has antiatherosclerotic, antithrombotic proviron steroid activity, increases the glomerular filtration rate, has a weak natriuretic effect. In diabetic nephropathy does not increase the severity of microalbuminuria. The pharmacokinetics of atenolol: after ingestion of the drug is rapidly absorbed from the gastrointestinal tract – approximately 50% of the dose ingested. Poor solubility in fats, bioavailability – 40-50%, time to reach maximum concentration in plasma after ingestion – 2.4 hours. Poorly penetrates the blood-brain barrier, held in neznachitelnbyh amounts through the placenta and breast milk. Contact with blood plasma proteins -. 6-16% Practically not metabolized in the liver. The half-life of 6-9 hours (increases in elderly patients). Excreted by the kidneys by glomerular filtration (85-100% unchanged). Renal dysfunction is accompanied by elongation of the T & frac; and cumulation with creatinine clearance less than 35 mg / min / 1.73 m 2 , the T & frac; is 16-27 hours, with clearance of less than 15 mg / min – over 27 hours (necessary to decrease the dose ). Output during hemodialysis. Amlodipine: after ingestion of amlodipine is rapidly absorbed from the gastrointestinal tract of 90%, the maximum concentration of drug in the blood observed after 6-12 hours. The equilibrium concentration of drug in blood plasma achieved after 7-8 days of its continuous use. The drug has a high volume of distribution – about 20 l / kg; bioavailability is 60-65%, the connection to plasma proteins . It is metabolized primarily in the liver to inactive metabolites. Less than 10% of an oral dose is excreted unchanged in, about 60% is excreted by the kidneys as inactive metabolites; 20-25% is excreted as metabolites in the bile and through the intestines, and in breast milk. It penetrates through the blood-brain barrier.

Pregnancy and lactation
Pregnant women should appoint Tenochek only in cases where the benefit to the mother outweighs the potential risk to the fetus.
Tenochek excreted in breast milk, so the feeding period it should be taken only in exceptional cases with great care.

Dosing and Administration
Inside, squeezed the required amount of liquid.
When hypertension and angina, the dose is 1 tablet per day.
If necessary, the daily dose may be increased to 2 tablets per day.
The maximum daily dose is 2 tablets.

Side effects:
Usually the drug is well tolerated, however, the following side effects may occur in some cases: