Clay M. Armstrong, MD, professor of physiology at the University of Pennsylvania
School of Medicine, will share the 1999 Albert Lasker Basic Medical Research
Award from the Albert and Mary Lasker Foundation. Armstrong was named with
Bertil Hille, PhD, professor of physiology and biophysics at the University of
Washington, and Roderick MacKinnon, MD, professor of molecular neurobiology and
biophysics at The Rockefeller University. The researchers will receive their
awards during a luncheon on October 1 in New York City.

The Lasker Award is often cited as a Nobel Prize predictor: 61 Lasker Award
recipients have subsequently received the honor. Armstrong is being cited for
pioneering research elucidating the physical processes underlying electrical
signaling in and between cells. His work unveiled the mechanisms governing the
behavior of ion channels. These basic components of all cells play a fundamental
role in the conduction of electrical impulses in nerve, muscle, and heart, and
control the central nervous system, including the brain, muscle contraction,
cardiac rhythm, hormone secretion, and many other vital biological events.

Since the 19th century, scientists have known that nerve impulses were
transmitted electrically. Exactly how they were propagated throughout the body,
however, was still mysterious. During approximately the same era, engineers
working on the first trans-Atlantic cables found that electronic signals would
fade and be lost without the use of booster stations along the way. What
Armstrong discovered years later was precisely how ion channels function as the
nervous system's booster stations, responsible for receiving and reproducing
signals as they travel along nerve fibers.

"Conveying nerve impulses through the body is like transmitting an electrical
signal faithfully over a very long distance," Armstrong explains. "Both require
the equivalent of amplifiers along the way. When a signal enters a cell, it
doesn't simply pass '"/>

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