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Tag Archives: National Medal of Science

The Woman Who Saved Millions of Lives

Gertrude Elion

Gertrude Belle Elion (1918-1999) was born in New York to Lithuanian- and Polish-Jewish immigrants. She excelled at school, and when her grandfather passed away from cancer, was determined to find the cure. She went on to volunteer as an assistant in a chemistry lab, and was eventually hired for just $20 a week. She used that money to pay for school, earning her Master’s in chemistry in 1941. Unfortunately, Elion was rejected for all fellowships and post-graduate positions because of her gender. Instead, she went to work for a supermarket, testing food quality. From there, she got a job as an assistant in a New York pharmacology lab (now owned by GlaxoSmithKline). Working under the supervision of George Hitchings, she developed two new anti-cancer drugs by 1950. Elion continued to work at the lab, and eventually became the head of its Experimental Therapy department. Despite never formally earning a Ph.D, she was a professor of pharmacology at Duke University between 1971 and 1999. Among the drugs that Elion developed are Purinethol (the first leukemia medication), Daraprim (to treat malaria), and Acyclovir (the first and most common antiviral medication, used to treat herpes, chicken pox, and shingles). Azathioprine, a drug to prevent organ transplant rejection which Elion discovered in 1963, has since been used to ensure successful kidney transplants for over 500,000 people. She also developed drugs to treat meningitis, gout, urinary, and respiratory infections. While Elion officially retired from drug-making in 1983, she was inspired to continue working due to the then-recent outbreak of HIV/AIDS. She continued working full time until the successful release of AZT, the first drug to treat AIDS. For all of this tremendous work, which saved the lives of countless thousands, Elion was awarded the Nobel Prize in Medicine in 1988. She received a National Medal of Science in 1991, and in that same year became the first woman ever inducted into the National Inventors Hall of Fame. (Elion holds 45 patents.) She finally received an honourary Ph.D from New York University in 1989, and another doctorate from Harvard when she was 80 years old. She is recognized as one of the greatest pharmacologists and biochemists of all time.

Vera Cooper (1928-2016) was born in Philadelphia. Her parents were Jewish immigrants from Eastern Europe (who changed their last name from Kobchefski to Cooper). From the young age of just 10, Cooper was interested in astronomy, and was later the only woman studying the subject in her college. She intended to continue graduate studies at Princeton but was forbidden because of her gender. Cooper went to Cornell University instead and studied astrophysics and quantum physics. There she also met her husband, Robert Rubin, who was pursuing graduate studies in chemistry. The two had four children, all of whom became Ph.D scientists and mathematicians. Rubin completed her Master’s in 1951 and went to Georgetown University for her doctorate. Around this time, she discovered that whole galaxies are rotating around their centres – an idea so revolutionary that it was initially rejected. Her 1954 Ph.D thesis was similarly revolutionary, showing that galaxies must be clumped in clusters. No one paid attention to this work for another two decades, when it was confirmed to be true. In 1965, Rubin was the first woman allowed to use Caltech’s famous Palomar Observatory. She then became a Senior Fellow at Washington’s Carnegie Institution, where her research was focused on “galactic and extragalactic dynamics”, among other things. Rubin made critical calculations with regards to galactic rotation rates, and together with her friend Robert Ford, discovered what is now known as the Rubin-Ford effect. In her studies, she found that galaxies are spinning so fast that they should be flying apart. They do not fly apart because gravity keeps them together. But, there is not enough visible matter in galaxies to generate so much gravity! This led Rubin to confirm the existence of invisible dark matter. This was perhaps her biggest breakthrough, and completely transformed astrophysics. For her tremendous achievements, Rubin has won multiple awards, including the National Medal of Science and the Royal Astronomical Society’s prestigious Gold Medal. There is also an asteroid named after her. Sadly, Rubin passed away earlier this week. Despite being 88 years old, Rubin continued her scientific research (focusing on the motion of distant stars) until the last days of her life. She was a pioneer for women in science, and worked tirelessly to get more women elected to the National Academy of Sciences. Rubin was proud of her Jewish heritage, and often spoke of the beauty and value of science and religion when studied together. In addition to half a dozen important scientific publications, Rubin wrote a book, and was featured in two documentaries. She was once described as an American “national treasure”.

Words of the Week

The first gulp from the glass of natural sciences will turn you into an atheist, but at the bottom of the glass God is waiting for you.– Werner Heisenberg, Nobel Prize-winning physicist