I'm about to do this on a Genesis child theme. I really tried picking a theme my client liked, but out of the blue with the project nearly finished they sprung their own artwork on me and want it for the homepage. So I had the site nearly up, and she sent me her own artwork that she wants to be the homepage. It's a full page and would have a different background than the rest of the site, no sidebars or widgeted areas, just three buttons.