A profound change in form from one stage to the next in the life history of a man as from being born a nobody, rising to super stardom and using that influence to fuck everything that moves.
A complete change of form, structure, or substance, as transformation by money, fame, fortune, plastic surgery thus propelling a man to seek sexual relations with global sluts irregardless of his beautiful wife at home with his children.
Pathology. A type of alteration or degeneration in which tissues are changed. For example, athletes who equate the size of their dick to the size of their bank account.

Tiger Woods quickly rose to superstardom status and was idolized by millions. Yet, he managed to keep his life with his beautiful wife and children private. He shocked the world as his metawhorephosis became public revealing that the "golden boy" had had numerous affairs with all sorts of whores and even fucked the waitress at Perkins in the church parking lot!