Health Implications

Populations at Risk for Vitamin B6 Deficiency

The following populations may be at risk for vitamin B6 deficiency and may require a supplement:

People who consume excessive amounts of alcohol

People with poor kidney function

People with autoimmune disorders, such as rheumatoid arthritis, celiac disease, and ulcerative colitis

Vitamin B6, Homocysteine, and Heart Disease

Homocysteine is an amino acid normally found in the blood. Studies have shown that elevated blood levels of homocysteine can be a risk factor for heart disease and
stroke. Because vitamins B6, B12, and folic acid are required for the metabolism of homocysteine, it is thought that a deficiency of any of the 3 may increase the level of homocysteine in the blood. Studies have failed to show that taking these vitamins as supplements in people with normal levels offers protection from heart disease.

Morning Sickness

There is evidence that high levels of B6 can help alleviate the symptoms of morning sickness during pregnancy.

Areas of Research That Have Not Been Supported by Clinical Data

Premenstrual syndrome (PMS)—There has been much anecdotal evidence that vitamin B6 can help relieve the symptoms of PMS—depression, irritability, bloating, mastalgia. However, clinical trials have failed to support this idea.

This content is reviewed regularly and is updated when new and relevant evidence is made available. This information is neither intended nor implied to be a substitute for professional medical advice. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with questions regarding a medical condition.