..The metabolic and perfusional changes in the cerebral cortex of ALS patients are likely to depend on upper motor neuron involvement, but they are not confined to the neurons of the corticospinal tract...

Structural changes in the midbrain with aging and Parkinson's disease: an MRI study

..Carvedilol also suppressed superoxide generation of human neutrophils. These properties of carvedilol should be suitable for treating hypertension resulting in cerebro- and cardiovascular diseases...

..These results suggest that cabergoline may have a neuroprotective effect on the substantia nigra of Parkinsonian patients because of its synergistic antioxidant activity with vitamin E as well as its action on dopamine receptor...

Identification of nitrated proteins in the normal rat brain using a proteomics approach

..The nitration of tyrosine has been suggested to play a role in the pathogenesis of neurodegenerative disorders such as amyotrophic lateral sclerosis (ALS), Parkinson's disease (PD) and Alzheimer's disease (AD)...

Yuka SakazumeDepartment of Neurology, Gunma University Graduate School of MedicineRinsho Shinkeigaku 44:541-4. 2004

..These mutations have been reported in Japanese sialidosis type II (P80L) and I (V217M). Further studies are required to reveal effects of gene mutations on residual enzyme activities and phenotypes...

Shinobu TanoDepartment of Neurology, Gunma University School of MedicineRinsho Shinkeigaku 42:966-9. 2002

..Decreased signal of ECD in the lesion where IMP uptake was increased could be due to decreased esterase activity. This report suggests that ECD-SPECT could fail to detect cerebral blood flow in the lesion with severe metabolic damage...

..A lymphoid follicle is a rare pathological finding in inflammatory myopathies. The immunohistochemical findings suggest that the lymphoid follicle would be involved in the specific role for the pathogenesis of MCTD...

Antioxidant properties of cabergoline: inhibition of brain auto-oxidation and superoxide anion production of microglial cells in rats

..While cabergoline is commonly used to treat the motor dysfunction of Parkinson's disease, it may also be effective in inhibiting oxidative stress, a possible mechanism of dopaminergic neuronal degeneration in Parkinson's disease...

Makoto UesugiDepartment of Neurology, Gunma University School of Medicine, Maebashi, JapanNeuropathology 22:61-5. 2002

..The results suggest that masses of phosphorylated neurofilaments are associated with structural abnormalities of the GA...

Health-related quality of life among persons living in Japan with a permanent colostomy

Naomi ItoDepartment of Adult Nursing Terminal and Long Term Care Nursing, School of Health Sciences and Nursing, Graduate School of Medicine, The University of Tokyo, JapanJ Wound Ostomy Continence Nurs 32:178-83; quiz 184-5. 2005

..To compare the health-related quality of life (HRQOL) of persons with a permanent colostomy to that of the general Japanese population and explore the factors influencing HRQOL...

..In this experiment, nefiracetam had a significant effect long after drug administration had ceased. Prolonged administration of nefiracetam may have ameliorating effects greater than those observed in only 15 days of drug administration...

Effects of sevoflurane anesthesia on carotid-cardiac baroreflex responses in humans

..The IC50 of propofol was 34.9 micromol.l(-1). Propofol shows a competitive inhibitory effect on the metabolism of ropivacaine (i.e., PPX production mediated by CYP3A4) in human CYP systems in vitro...

..Since this effect is seen with a wide range of antipsychotics, such as haloperidol and clozapine [Life Sciences 71 (2002) 947], group II mGluR agonists deserve further attention for possible antipsychotic activity...

Ulcerative colitis: factors affecting difficulties of life and psychological well being of patients in remission

Makoto TanakaDepartment of Adult Nursing Terminal and Long Term Care Nursing, Graduate School of Medicine, The University of Tokyo, Tokyo, JapanJ Clin Nurs 14:65-73. 2005

..This study was conducted to elucidate factors that influence perception of difficulties of life and psychological well being of patients with ulcerative colitis in remission...

[Therapy for patients with early-stage Parkinson's disease]

Makoto TanakaNihon Naika Gakkai Zasshi 92:1426-31. 2003

[Acceptance of memory impairment and satisfaction with life in patients with mild to moderate Alzheimer's disease]