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"I am very concerned to hear of the disappearance of my old friend Andrew Koenig," said the actor and Christian activist, who is best known for playing rascally teen Mike Seaver on the 1985-92 series.

"I can remember many of the fun times we had on the set of Growing Pains. I am praying for his family during this time of distress and for his safe return."

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Friends and family haven't seen Koenig since Feb. 14. They reported the 41-year-old missing after he never showed for a Feb. 16 flight from Vancouver to the U.S.

"Andrew, if you're reading this, please call me," Cameron added. "Mike and Boner could always work things out when they put their minds to it. I'm praying for you, pal. Hope to hear from you soon."

Jeremy Miller, who played younger brother Ben Seaver, is also wishing for the best.

"It is really sad to hear what is going on," he said in a statement. "Andrew is a talented guy and my family and I are hoping for a positive outcome of this situation."

Koenig is said to have suffered from depression.

Vancouver authorities have said that they are conducting an active missing persons investigation and Koenig's family is receiving daily updates; however, the trail technically went cold on Feb. 14. The last confirmed sighting of the missing man was in the 1,001-acre Stanley Park.

Your information may be shared with other NBCUniversal businesses and used to better tailor our services and advertising to you. For more details about how we use your information, see our Privacy Policy. If you are located outside of the U.S., your information may be transferred to, processed and used in the U.S.