Botulinum toxin in aesthetic medicineThanks to its proven efficacy and favourable safety profile, the injection of botulinum toxin (BT) is rapidly gaining popularity in the field of aesthetic medicine. Although BT is approved by the US “Food and Drug Administration” (FDA) only for the treatment of vertical glabellar lines and primary axillary hyperhidrosis, off-label use in the approach of dynamic wrinkling and facial sculpting is widespread. There are different BT products on the market, each with their specific characteristics. Before treatment, a thorough history and clinical examination should be performed in order to identify the contra-indications and to adjust the patient’s expectations, which are often too high. The patient should be well informed about the possible risks and side effects. A correct treatment procedure demands a thorough knowledge of the product, the human anatomy and the injection technique. Despite this cognition, one should always be aware of the possible complications and have the know-how to handle them. This manuscript aims at giving a better insight in the responsible use of BT as a minimal invasive technique in aesthetic medicine.