The Regional HIV/STI Plan for the Health Sector 2006-2015 is a tool to assist health services and systems in the Americas to more effectively respond to the HIV epidemic and to prevent and control STI. It is meant to strengthen national plans in all countries of the Region. The ten year length of the Plan encourages international and national planners to consider the long-term impact and sustainability of programs, and view the trajectory of the disease in relation to other long-term economic and human development goals. The Regional Plan will be a valuable resource to improve institutional coordination and build social and economic capital to halt the spread of HIV now and for years to come.