After being murdered for quitting his role as a ruthless yet moral government assassin, Al Simmons (Michael Jai White) is sent to Hell, where he makes a pact with the demon Malebolgia--if Simmons is allowed see his lover, Wanda, again, he will agree to lead the demon's armies to storm the gates of Heaven. Transformed into a superhuman entity with shape-shifting powers and quick regeneration capabilities, Simmons (soon to be dubbed "Spawn" by Malebolgia's crony, The Violator) returns to Earth and attempts to reunite with Wanda, not knowing that five years have passed. He also seeks revenge on his former boss and killer, Jason Wynn (Martin Sheen), who has made a deal with The Violator to develop a lethal virus to take over the world, where Wynn is promised to be king.