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An anonymous author writing as a Mr. Vivenair published A Journey Lately Performed Through the Air in an Aerostatic Globe, Commonly Called an Air Balloon, From This Terraquaeous Globe to the Newly Discovered Planet, Georgium Sidus in 1784.

R. R. Winterbotham's "Clouds over Uranus" was published by Astounding in March 1937

In Ramsey Campbell's The Insects from Shaggai (1964), a Cthulhu Mythos story, Uranus is known as L'gy'hx and is inhabited by cubical metallic many-legged creatures who worship Lrogg. They entered in religious conflict with the Shan.

The novels #5 ("Push towards Uranus") and #22 ("Position Oberon") in the Mark Brandis SF book series take place on and around Uranus.

In Larry Niven's novel A World Out of Time (1976), Uranus is outfitted with a massive fusion motor and used to gently move the Earth outward from an artificially brightening sun caused by a civil war between Earth and its colonies.

Geoffrey A. Landis's short story "Into the Blue Abyss," part of his short-story collection Impact Parameter and other Quantum Fictions (2001) discussed an expedition to Uranus in search of life.

Fritz Leiber's 1962 short story "Snowbank Orbit" has three Earth-ships, fleeing from interstellar invaders, attempt a desperate aero-braking maneuver in the atmosphere of Uranus at 100 miles per second.

In Larklight, Uranus is called Georgium Sidus, 'Star of George'. It has Sprout islands on it, and is also inhabited by a four-armed merman-like race, who live in the Sprout's floating bladders beneath the surface along with other aquatic races.

In Zombie Butts from Uranus, it is stated that the zombie butts came from Uranus. It is also the setting of one of the chapters.

In Space Patrol (1962) episode: The Dark Planet - Professor Heggerty and his daughter Cassiopeia are baffled by a plant sample from Uranus with a mind of its own. Following the disappearance of a 20 strong survey team on Uranus, Colonel Raeburn dispatches the Space Patrol crew to locate larger versions of the plant, where they discover the adult specimens of the plant are far from friendly.

In Space Patrol (1962) episode: The Invisible Invasion - On Uranus, the Duo's are planning to seize power on Earth by taking over the minds of everyone at Space Headquarters, including Colonel Raeburn. The one person seemingly unaffected by the Duo's power is Professor Heggerty, who is installed beneath his electronic hair-restorer!

In the 90's Nickelodeon series, Space Cases, the character of Bova, played by Rahi Azizi, is from Uranus. He has a distinction from other characters in the series, having an antenna growing from his forehead.[2]

In All-Star Comics #13 the JSA are gassed by Nazis and rocketed to different planets. Sandman (comics) finds himself heading toward Uranus, a planet so cold that the population's brains are housed in bodies of crystal. When Sandman lands on the planet, the lack of oxygen nearly kills him until a citizen rescues him with an oxygo-tank. In gratitude, Sandman agrees to help the King of the planet battle his nemesis, Kafta, the evil one, and defeats him. The King presents Sandman with a crystal that cures brain cancer and books that explain its use, which come in handy for reading on the long trip back to Earth.

In a Superman comic Uranus' inhabitants are actually small mechanical robots. Their civilization is quite advanced, they can tour the solar system in circular space ships and although having weapons like "lance throwers" and "flame cannons", they have other advanced technologies like "transporta-rays" (which transport things and animals) and an interplanetary zoo.

In September 1949, referring to a book called "Children's Picture Book of Animals", they try catching an earth animal from each page, including a human man and woman. Superman deceives them into thinking all humans are robots, which they have no interest in (WF No. 6, September 1949: "The Alphabetical Animal Adventure").

In Sailor Moon (Anime/Manga), a female protagonist named "Sailor Uranus" (Haruka Tenoh in human appearance) makes an appearance in the Sailor Moon Franchise. Sailor Uranus has lived on Miranda (One of Uranus' Moons) before she was sent to Earth. Sailor Uranus doesn't appear in Sailor Moon until halfway through the Sailor Moon Franchise; she disappears from the Sailor Moon Series for quite some time before she does a re-appearance in the final season of the Sailor Moon Franchise. Although, the explanation of what her powers are based on (sky and wind) are very clear in the franchise with her only introducing three powers in the franchise than more.

In the video game Mass Effect, the Human Systems Alliance has mined Uranus for Helium-3. In the sequel, Mass Effect 2, should the player attempt to use the planet scanning mechanic to launch a probe to extract resources from Uranus ("probing Uranus"), the starship's AI will respond "Really, Commander?" before deploying the probe. A second probe triggers a deadpan "Probing Uranus" response, after which the voice switches to stock lines used for all other planets.

In Blue Mars by Kim Stanley Robinson (1997), two characters visit Miranda, which is being preserved by the colonists of the Uranian system as a primal wilderness; the other sizable moons of Uranus are being ambitiously colonised at the time with the help of fusion lanterns placed in Uranus' upper atmosphere to provide more light.

In the PC real-time strategy game Earth 2160, the UCS evacuation ship Phoenix was hidden among a Shield generator and a small UCS Base on the surface, in orbit around Oberon.

In the Starhunter TV series episode "Cell Game" (2000), a maximum security prison has been established below the Oberon surface to keep the worst of the worst in an environment from which there is no hope for escape. Series hero Percy (Tanya Allen) is imprisoned there on false charges as bait to draw her bounty hunter uncle Dante Montana to the hostile world and her rescue. Action in Starhunter is restricted to the solar system, its planets and moons.

In Donald A. Wollheim's short story "Umbriel" (1936), this moon is really a gigantic dead animal, who came to die in an orbit around Saturn. The protagonist, an astronaut, discovers huge worms appearing from the ground, and he concludes they are eating the flesh of the immense corpse. Before he leaves he realises the worms have metal collars, which mean there is a species of intelligent beings living in the interior of the corpse, and they are the worms' masters.