The protein encoded by this gene belongs to a series of ectoenzymes that are involved in hydrolysis of extracellular nucleotides. These ectoenzymes possess ATPase and ATP pyrophosphatase activities and are type II transmembrane proteins. Expression of the related rat mRNA has been found in a subset of immature glial cells and in the alimentary tract. The corresponding rat protein has been detected in the pancreas; small intestine; colon; and liver. The human mRNA is expressed in glioma cells; prostate; and uterus. Expression of the human protein has been detected in uterus; basophils; and mast cells.

Predicted cell location: Cytoplasm. Positive control: Human colon and ovarian cancer tissue. Recommended dilution: 1/10-50 The image on the left is immunohistochemistry of paraffin-embedded Human colon and ovarian cancer tissue using ENPP3 antibody at dilution 1/15, on the right is treated with the synthetic peptide. (Original magnification:x200)

Predicted cell location: Cytoplasm. Positive control: Human colon and ovarian cancer tissue. Recommended dilution: 1/10-50 The image on the left is immunohistochemistry of paraffin-embedded Human colon and ovarian cancer tissue using ENPP3 antibody at dilution 1/15, on the right is treated with the synthetic peptide. (Original magnification:x200)