Background. In the clinical picture for minor abnormalities of connective tissue (MAC), in addition to MAC manifestations, psychophysiological disorders, such as increased neuroticism and anxiety, are also present. MAC patients are prone to develop these disorders, particularly in stressful situations. Aim. To determine protective compensatory responses in female patients with the syndrome of heart connective tissue dysplasia considering the syndrome severity. Materials and methods. 145 young women (mean age, 24.46±2.12) with MAC manifestations of different severity (mild in main group and moderate in reference group) were evaluated using E. Heim and S. Subbotin questionnaires and the Toronto Alexithymia Scale. Results. Significant predomination of adaptive coping styles in all fields was observed in clinically healthy women with mild MAC. Women of the reference group used non-adaptive coping responses more frequently than healthy women from the main group. Women with the syndrome of heart connective tissue dysplasia of moderate severity who chose non-adaptive emotional and behavioral coping styles had significantly lower stress resistance and higher alexithymia than women with adaptive behavior. Conclusion. The study results are recommended to be used for women with MAC to increase efficacy of individualized prevention of cardiovascular complications.