In reply to Re: Anyone ever heard of Opipramol?, posted by Lamdage22 on February 13, 2018, at 9:43:42

i would not take a tca w/ seroquel, personally.

i still think that if you need something for depression, you should look for something more modern, more stimulating. wellbutrin, maybe see if they will prescribe Provigil or Nuvigil. There's some limited data on Provigil in people stable on neuroleptics, and it seems helpful for a subset of people.

prozac has been combined with zyprexa, with good results for some people. I would think you'd need to have the tranquilizer doses reduced a bit w/ prozac, but i could be wrong.

In reply to Re: Anyone ever heard of Opipramol?, posted by Lamdage22 on February 14, 2018, at 3:00:40

> then i will ditch seroquel and take more zyprexa

I like that idea.

Slowly.

I wouldn't go up past 30 mg/day of Zyprexa. You may not need such a high dosage, but I think it is reasonable to keep the dosage of Zyprexa at 20-30 mg/day while manipulating the dosage of Seroquel. Be aware, though, that Zyprexa has been known to precipitate mania in some individuals.

In reply to Re: Anyone ever heard of Opipramol?, posted by Lamdage22 on February 15, 2018, at 6:09:30

hi, lamdage.

I don't know if zyprexa and seroquel compete, but on the group level, people are usually better off on just 1 neuroleptic at a time. I think you'd be better off on just zyprexa, because you'd have far less sedation, which might help your mood.

In reply to Re: Anyone ever heard of Opipramol?, posted by Lamdage22 on February 15, 2018, at 13:49:42

> well if i stop Seroquel there will be a void!!

I think that depends upon:

1. Your diagnosis?

2. The symptoms you are treating?

3. How does Zyprexa help you?

4. What is your fear were you to discontinue Seroquel entirely?

Answering all of these questions might help people to better address your issues and concerns.

* I've known about opipramol for a long time. It is not available in the USA, and I did not think it would help me any better than imipramine or nortriptyline. Interestingly, opipramol blocks sigma receptors. I would have to do some reading to review what sigma receptors are all about. Linkadge would very likely know about them.

If i replace it with equivalent Zyprexa dosages, there is no fear to discontinue it.

> Answering all of these questions might help people to better address your issues and concerns.> > * I've known about opipramol for a long time. It is not available in the USA, and I did not think it would help me any better than imipramine or nortriptyline. Interestingly, opipramol blocks sigma receptors. I would have to do some reading to review what sigma receptors are all about. Linkadge would very likely know about them.> > * Xyprexa is much stronger than Seroquel at dopamine D2 receptors. > > > - Scott