We've been talking about visiting Italy for some time now and are finally getting semi-serious about a trip next year. (I visited several times on business back in the '70s but couldn't take her with me, for which she's never forgiven me. So - time to atone for my sins.)

We're thinking about maybe spending a week in Rome and its environs and another week in Tuscany (and hopefully meet up with our Scottish friends for that portion.) Would love to visit some of the biggies, esp. the Marchese Piero Antiniori whose wines we much admire. Anyone have any advice on who/what to see? TIA.

I recommend a couple days sightseeing in Florence and a day devoted to Siena (unfortunatley I have not been to Siena myself.) For contrast to Rome, very urban, you might want to visit some small hill towns or a coastal city. I have enjoyed the beach at Rimini on the Adriatic Coast and would love to visit Positano with its buildings "clinging to the rock face" on the Amalfi Coast.http://www.positano.com/en/positano-info These are widely spread out towns and cities so it might not be possible to visit all of them.
I don't have any experience visiting wine producers in Italy so can't advise there although I do know that Castello Banfi welcomes visitors and has luxury rooms and suites at Il Borgo. There is a wine bus that leaves from Florence or Siena to Montalcino and Castello Banfi if you are interested in that.

Thanks Jane. We may try to share a villa near Siena with our friends for the second week and drive around from there. (I have no experience driving in Italy, but he does, traveling extensively across the continent as the Scottish national fencing champion, with saber - don't want to get in a knife-fight with him!).

Italy is very beautiful place. I would suggest you to stay at least for 2-3 Weeks. There are number of places to visit like -
San Gimignano
Manarola (Cinque Terre)
Leaning Tower of Pisa
Lake Como (Italian Lake District)
Positano (Amalfi Coast)