関連製品

アプリケーション

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション

Abreviews

特記事項

ICC/IF

Use at an assay dependent concentration.

WB

Use a concentration of 0.2 - 2 µg/ml. Detects a band of approximately 37 kDa (predicted molecular weight: 34 kDa).

Dot blot

Use at an assay dependent dilution.

ターゲット情報

機能Has both an apurinic and/or apyrimidinic endonuclease activity and a DNA N-glycosylase activity. Incises damaged DNA at cytosines, thymines and guanines. Acts on a damaged strand, 5' from the damaged site. Required for the repair of both oxidative DNA damage and spontaneous mutagenic lesions.

組織特異性Widely expressed with highest levels in heart and lowest levels in lung and liver.

配列類似性Belongs to the Nth/MutY family.

発生段階Expression levels are regulated during the cell cycle with increased levels during early and mid S-phase.