Summary

This study was designed to investigate the physiological properties of adult heart using
cardiovascular magnetic resonance imaging in normal volunteers in Latin America.

Description

Evaluation of myocardial mass, volumes and function is essential in the management of
cardiovascular diseases. While 2D and 3D echocardiography play a major role in determining
these parameters cardiovascular magnetic resonance (CMR) has become a widely accepted gold
standard for these measurements due to its high accuracy and reproducibility.

However, determining normal reference standards for CMR is crucial for proper use of the
method. Previous reports have established normal ranges for both fast low angle shot
techniques6 and the more commonly used steady state free precession methods including values
normalized not only to body surface area but to age and gender as well. Despite these
general references, variability in normal ranges have been reported previously when
ethnicity is taken into account. The ongoing Multi-Ethnic Study of Atherosclerosis (MESA)
trial has measured cardiovascular function in participants with different ethnical
backgrounds, reporting differences in the African-American and Asian-American groups.

Latin-American populations have generally been underrepresented in most clinical
cardiovascular trials despite representing a growing percentage of heart disease patients in
the world and, particularly, in the USA12-15. While the MESA trial evaluated cardiac
function by CMR in Hispanics, data was limited to participants living in USA, within a
restricted age group and representing only a small fraction of their entire cohort. It is
thus essential to acquire specific data for this population regarding normal CMR values in
order to permit not only precise clinical evaluation of Hispanic patients but also accurate
assessment of ventricular function figures from Latin American countries in future CMR and
drug trials.

To accomplish this goal, we propose a multicenter study to collect CMR data from countries
in Latin America in normal participants with 20-80 years of age.

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Medical and Biotech [MESH] Definitions

Healthy People Programs

Healthy People Programs are a set of health objectives to be used by governments, communities, professional organizations, and others to help develop programs to improve health. It builds on initiatives pursued over the past two decades beginning with the 1979 Surgeon General's Report, Healthy People, Healthy People 2000: National Health Promotion and Disease Prevention Objectives, and Healthy People 2010. These established national health objectives and served as the basis for the development of state and community plans. These are administered by the Office of Disease Prevention and Health Promotion (ODPHP). Similar programs are conducted by other national governments.

Nutrition Policy

Governmental guidelines and objectives pertaining to public food supply and nutrition including recommendations for healthy diet and changes in food habits to ensure healthy diet.

Nerve Transfer

Surgical reinnervation of a denervated peripheral target using a healthy donor nerve and/or its proximal stump. The direct connection is usually made to a healthy postlesional distal portion of a non-functioning nerve or implanted directly into denervated muscle or insensitive skin. Nerve sprouts will grow from the transferred nerve into the denervated elements and establish contact between them and the neurons that formerly controlled another area.

Surgical Clearance

Process of evaluating the health of a patient and determining if they are healthy enough for surgery.

Healthy Diet

Dietary patterns which have been found to be important in reducing disease risk.

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