Broncos vs. Chiefs
Denver Broncos boast a solid 16-6 SU record on the road in the last 22 road games and 6-0 SU against Kansas City Chiefs in their last six meetings home and away. The last time the Broncos lost to the Chiefs was in 2012, a 7-3 loss in week 17 of the 2011-2012 season when Tim Tebow was the shot-caller. Since Peyton Manning took over the starting role in Denver, the Broncos have been dialled into this divisional rivalry. Even the advent of Alex Smith, a quality quarterback, to Kansas City didn’t change the dynamic the rivalry took on. Denver went 8-9 ATS in 2014 while Kanas went 10-6 ATS. Chiefs also went just 4-2 as home faves while Broncos went 1-1 ATS as road underdogs with a 3.5-point margin of victory. Total has gone UNDER in five of Denver’s last seven games

Cardinals vs. Bears
Chicago may be 4-1 SU in their last five games when playing Arizona, but this is the first time they’ll be taking on a Bruce Arians coached Cardinals since their last meeting in December, 2012. It’s also a different Bears of sorts under John Fox, although much of the roster remains the same. Arizona finished a league-leading 11-5 ATS, which included a 1-1 ATS mark as away faves and a 5-4 ATS mark as the away team. Chicago were 1-3 ATS as home underdogs. The glaring stat: Bears are 0-5 SU in their last five games.

Falcons vs. Giants
NY Giants are 2-5 ATS against the Falcons at home, but they won their last meeting over the Falcons 30-20 in October last season to improve to 5-1 SU in their last six games against the Falcons at home. The total has gone UNDER in five of the last six games between this pair in NY, but the last meeting snuck just UNDER the 50.5-point closing total. The last three meetings hit the UNDER, including a 34-0 win over NY by Atlanta and a 24-2 win by NY in 2012. Going against the Giants overall is a 1-4 SU record in their last five home games.

Lions vs. Vikings
The Vikings went 7-9 SU in Teddy Bridgewater’s rookie season but 10-6 ATS. They went 4-1 SU in their last five home games; the loss (ironically) was a 17-3 loss at home to the Detroit Lions last season. They lost both meetings with the Lions last season, including a 16-14 loss in Detroit in week 15 NFL betting. Detroit have won three of the last four meetings with Minnesota.

Texans vs. Panthers
Although the Texans finished 9-7 SU last season, their record on the road is a subpar 5-14 SU in their last 19 outings around the league. In order to mastermind the upset in Carolina they’ll need to transcend that road form. Carolina, meanwhile, are 6-1 SU in their last eight games, which includes a run of four straight wins to close the 2014 season, a win over the Cardinals in the wildcard round of the playoffs and a season-opening win over the Jaguars last weekend. The total has gone UNDER in four of Houston and Carolina’s last six games.

Patriots vs. Bills
The Bills won the last meeting over the Patriots, but it was a meaningless game as the Patriots had sewn up the AFC top seed ahead of week 17 last season. The NFL odds trend for this matchup is a 7-1 SU record by the Patriots over the Bills and given that this pivotal AFC East clash takes place early in the season, the premium on the win couldn’t be greater. The total has gone OVER in six of New England’s last eight games when playing Buffalo Bills.

Chargers vs. Bengals
The Bengals have a 13-4-1 ATS mark in their last 18 games at home and they are 16-3-1 in their last 20 games that have kicked off at 1 pm (9-1-1 at home). The total has gone UNDER in 7 of Cincinnati’s last 10 games. The Chargers have the last win over the Bengals, a playoff win that goes back to two seasons ago. The win snapped a three-game winning streak by the Bengals over the Chargers. Chargers went 4-3-0 ATS last season as away underdogs and 4-4-0 ATS as the away team. Bengals went 4-3-1 ATS at home last season with a 2.5-point margin of victory on average.

Niners vs. Steelers
The San Francisco Niners take a 2-4 SU record in their last six games to Pittsburgh, a mark that is blemished by their poor finish to the 2014-2015 season that saw them win just one of their last five games and finish on an 8-8 SU mark. Steelers clinched the AFC North title last season only just but they enter the new season amidst many question marks. They may be 11-4 SU in their last 15 home games, but of serious concern is their 1-4 SU mark in the preseason, compounded by an opening loss to the Patriots on the road. This is the first meeting between this pair since 2011, which San Fran won 20-3 at home as the 3-point home chalk

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Rams vs. Redskins
St. Louis Rams take a favorable 5-2 SU record over the Washington Redskins in the last seven meetings to the nation’s capital, a run of form underscored by an inspired win over the Seattle Seahawks in week 1. The Redskins are just 1-8 SU in their last nine games and the total has gone UNDER in four of the last five meetings in Washington.

Bucs vs. Saints
Tampa Bay are 0-5 SU in their last five games and just 1-5 SU in their last six road games. Last season, the Bucs finished 2-14 SU, a mark comprised of two road wins. The Saints may be just 3-6 SU in their last 9 games, but they are coming off a rather bizarre season and NFL bettors figure they’ll be more competitive this season. Particularly against a rookie quarterback Jameis Winston, who is coming off a humiliating loss to the Titans in week 1 and has a steep learning curve ahead of him. The total has gone OVER in five of the last seven games at the Superdome.

Titans vs. Browns
By the numbers, the prognosis is bleak for the Tennessee Titans: they are 1-10 SU in their last eleven games and just 2-4 SU when playing Cleveland in the previous six meetings. Nevertheless, this is a revamped Titans side that could factor in Cleveland, marking their second road game to start the new season. Browns narrowly beat the Titans 29-28 last season, a game that saw Brian Hoyer rally the Browns to victory on the road.

Ravens vs. Raiders
The Ravens are 5-1 SU in their last six games over Oakland on the road and the total has gone UNDER in five of the last six games between this pair in Oakland. Both the Ravens and Raiders opened their season on a loss, but in the broad spectrum of the season Ravens are expected to be contenders while the Raiders merely also rans. The last meeting between this pair saw the Ravens blow the Raiders 55-20 in Baltimore, singlehandedly cracking the 48-point total trading at the time and easily covering as the 7.5-point favourites.

Dolphins vs. Jaguars
Miami boast a 5-1 SU record over the Jacksonville in the last six meetings on the road and the total has cashed in five of the last five overall meetings between this pair. The Jaguars are a poor 6-12-2 ATS in their last 20 games overall, which includes a 6-9-1 ATS mark in 2014 and they are 3-5 ATS in their last eight home games.

Cowboys vs. Eagles
The Eagles went 5-3 ATS at home last season with a staggering 9.4-point margin of victory on average and 5-2 ATS as home favorites with an even higher 12.1-point margin of victory on average. In their last 23 home games, they went 8-14-1 ATS and they are just 2-4 ATS against Dallas in their last six meetings in Philadelphia. The Cowboys went a perfect 8-0 SU on the road last season and they are 9-1 SU in their last ten road encounters. The OVER cashed in 7 of the last 8 Dallas games on the road while the Eagles boasted a league-leading 11-5 over-under mark in 2014.

Seahawks vs. Packers
The Packers went 12-6 in over-under betting last season (including playoffs), which represents a 66% winning ratio for OVER bettors. They boast a 5-0 SU record over Seattle at Lambeau Field, but they lost the last three games to the Seahawks (all at CenturyLink), including the NFC Championship game last season. The total has gone OVER in seven of the last nine games at Lambeau and it has gone OVER in five of the last seven meetings between this pair.

Jets vs. Colts
The Colts have a solid home record over the last two seasons which stands at 12-4 SU and since 2014, they boast a league-leading 12-6-1 ATS record with a 4.1-point margin of victory on average. However, they are 1-4 ATS in their last five games when playing NY Jets. The Jets are 3-3-1 ATS in their last seven road games and 4-7-2 ATS in their last 13 games on the road. The total has gone OVER in five of the last six games between this pair.