HSA domain profile

The helicase/SANT-associated (HSA) domain is a predicted DNA-binding domain of
~75 amino acids [1], which is found in the eukaryotic SRCAP/p400/DOM and
SNF2/brahma families [2]. While each family has the core sequences that define
the HSA domain, they each also have additional sequences that distinguish
these families from one another. For example, the sequence HWDY(L/C)EEEM(Q/V)
is found in the SRCAP/p400/DOM family, whereas the sequence HQE(Y/F)LNSILQ is
found in the SNF2 /brahma family [2]. In addition to the SANT and helicase
(see <PDOC51192>) domains, the HSA domain is also found in association with
bromo (see <PDOC00550>) [1].

Drosophila domino (DOM), the homolog of SCRAP. It is essential for
organismal viability and has been implicated in several aspects of fly
development, including hematopoeisis, wing development, and female
fertility.

Mammalian SRCAP.

Mammalian SWI2/SNF2-like ATPase-containing p400/Domino.

The profile we developed covers the entire HSA domain.

Last update:

May 2006 / First entry.

Technical section

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