Results ①Ber,sildenafil (Sild),papaverine (Pap) and amrinone (Amr) could concentration-dependently relax the smooth muscle of corpus cavernosum and the rank order of potency was: Sild>Ber>Pap>Amr. Their EC_ 50 was 0.84,6.20,15.00 and 27.69 μmol/L respectively.

Of them 1 case had received prostaglandin E,papaverine and phentolamine injection into cavernous body of penis,which led to ED; 1 had priapism when experiencing sexual intercourse after taking sildenafil; 1 had primary sarcoma of the penis;

Methods Group A:Primary hypospadias repair in 50 cases. Continuous inverting suture to shape up new urethra and fixed on to cavernous body of penis,multilayer suture undersurface of skin flap to cavernous body of penis with multi point equality and without interruption and cavity from bottom to top of root of penis.

Methods 45 patients with ED were examined by CDUS and hemodynamics of the cavernous artery and the deep dorsal vein of penis before and after having injected vasoactive agents into the cavernous body of penis were observed.

The function of penile erection the erectile tissue in corpus cavernosum penis the microstructure of testes and the synthesis of testosterone were affected seriously by CRF, and the decreasing of the concentration of testosterone and the erectile tissue in corpus cavernosum penis may be one of the most important mechanisms.

AIM and METHODS: Thirty male Wistar rats were randomly divided into three groups which were given the synthetic diets for 5 weeks. The effect of zinc deficiency (ZD)on nitric oxide synthase Ⅰ(NOS 1)in the corpus cavernosum penis (CCP) was observed by means of immunohistochemistry. RESULTS:Zinc contents in plasma and organs of ZD rats decreased significantly.

In the functional experiments, the maximal contraction induced by norepinephrine(NE) was not decreased significantly after pretreatment with CEC. The pA2 values of two α1AR selective antagonists, 5MU,BMY7378, for antagonizing NEinduced penile corpus cavernosum contraction had a high correlative association with the pKI values for cloned α1AAR.

Needle biopsy of the corpus cavernosum with the Biopty gun system has been performed in impotent patients for obtaining erectile tissue to identify the presence of intracavernous structures (smooth muscle cells, collagen, arteries, and nerves).

Moreover, there is a potential risk of damage to the corpus cavernosum.

Penile fracture (PF) is an uncommon injury defined as the rupture of the tunica albuginea and corpus cavernosum of the penis, usually resulting from direct blunt trauma to the erect penis during sexual intercourse or masturbation.

Clearly, novel molecular targets in the corpus cavernosum smooth muscle (CCSM) need to be identified and evaluated for the potential in development of additional oral agents or gene therapy for ED.

Peyronie's disease is an idiopathic, localized connective tissue disorder of the penis that involves the tunica albuginea of the corpus cavernosum and the adjacent areolar space.

Despite the central and peripheral effects of androgens on the nervous system, the local effects of androgens in the corpus cavernosum penis and their importance for erectile function is still unclear.

The significant and age-independent high androgen and low estrogen-alpha receptor distribution found in both groups suggests a possible peripheral effect of androgens at the level of the corpus cavernosum penis in adult humans.