Severe digoxin intoxication in a child treated by infusion of digoxin-specific Fab-antibody-fragments

Rossi, R.; Leititis, J.U.; Hagel, K.J.; Smolarz, A.; Brandis, M.

1984

European Journal of Pediatrics 142(2): 138-140

Severe digoxin intoxication in a child treated by infusion of digoxin-specific Fab-antibody-fragments

Accidental digitalis ingestion in children is a rare, but potentially life-threatening emergency. We report the case of a 2 10/12-year-old boy with accidental ingestion of 6 mg beta-Acetyl-digoxin. Soon after admission, the boy developed sinus bradycardia, SA and AV-block, of increasing severity without circulatory impairment. As the serum digoxin level reached 21.7 ng/ml digoxin-specific Fab-antibody-fragments were used to bind free serum digoxin. Immediately after infusion, serum free digoxin was below the detection limit, whereas total digoxin peaked at 219 ng/ml 5 h thereafter. The arrhythmias did not subside totally, so that in addition, a transvenous pacemaker was placed, but never used. The antibody-infusion was well tolerated and the boy was discharged in good health.