WEBVTT 6 C13KATH RESEARCH GOING ON ATMARQUETTE UNIVERSITY JUST MIGHTCHANGE HOW YOU VIEW THE STATE OFADDICTION IN WHAT YOU ARE SEEINGDURING THIS DRAMATIC ENCOUNTER.>> DON'T MAKE A POOR DECISION,OK?KATHY: THE DRIVER BOLTS, DESPITETHE CONSEQUENCES.THE GOAL IN THIS MU LAB IS TOZERO IN ON HOW OPIOIDS ALTER OURBRAIN AND GUIDE OUR BEHAVIOR.>> WHAT PARTS OF THE BRAIN,PREFRONTAL CORTEX, IS ALTERED.HOW IS THAT ALTERED AND BEATINGPEOPLE TO MAKE POOR DECISIONS?DECIDING TO USE DRUGS EVENTHOUGH THE WILL BE ADVERSECONSEQUENCES LIKE JAIL, THINGSLIKE THAT, AND HOW CHANGES LEADTO THOSE.KATH THIS IS YOUR BRAIN ONDRUGS.>> THAT'S RIGHT.KATH PINPOINTING THOSE CHANGESIS DONE UNDER THE MICROSCOPEWITH BRAINS THAT MIMIC OUR OWNMAKEUP.THEY ARE THE MOST IMPORTANTMEMBERS OF THE LAB.KATH LAB MICE ARE KEY.THIS ONE IS THE CONTROL TO BECOMPARED WITH OTHERS EXPOSED ANDACTUALLY SELF ADMINISTER THEOPIOID.>> IT SHOWS THEY ARE MOTIVATEDTO SEEK OUT THE DRUG BECAUSE ITIS REWARDING.KATHY: THE AIM IS TO REVERSE THEDAMAGE DONE TO THEDECISION-MAKING OF THOSE IN THETHROES OF ADDICTION.>> WE JUST HIT HER WITH NARCAN.>> ONCE YOU ARE AN ADDICT, YOUARE AN ADDICT FOR LIFE, BUT OURGOAL IS TO GET PEOPLE TOREGULATE THE BEHAVIOR MOREAPPROPRIATELY.KATHY: REBUILDING THE BRAIN'SABILITY TO DECIDE, TO RELAPSELESS, TO USE LESS, PERHAPS BUILDA BETTER NARC OR ANOTHERCOMPLETELY DIFFERENT THERAPY.THE COOLES THING YOU COULDFIGURE OUT HERE MIGHT BE WHAT?>> IF WE COULD USE PHOTOSTIMULATION, LIKE TO ACTIVATECHANNELS IN YOUR BRAIN TOREVERSE CHANGES AND PREVENTRELAPSING.