Dan Slott will shoulder writing duties on the six-issue plotline, which kicks off in March's issue #682. Stefano Caselli will provide artwork for the first two and last two issues.

"[Doc Ock's] got one shot for one master plan. He's going for the whole thing. He's going for the world… This is Otto Octavius's big grab for the greatest master plan of all time," Slott told CBR.

Slott added that the story will rival his recent 'Spider-Island' event in scope, and remain self-contained within the Amazing Spider-Man title.

Doctor Octopus recently defeated Iron Man, Hank Pym's Avengers Academy recruits and the Fantastic Four's Reed Richards in other Marvel titles as part of the build-up to the anniversary arc.

"I've never done a Spider-Man story on this scope before," the writer explained. "I think a lot of the stuff I do is on character, but this one I think the focus is a lot more on action and adventure.

"It's so big and the fallout from it is going to be huge. It's going to be neat at the end of the day when this is over where all the pieces are on the table. They're going to be in a lot of interesting spots."