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**Psychoneuroimmunology** is a relatively new discipline which deals with CNS-immune system interactions. The evidence for such interactions was reviewed, as was the **neuroendocrinologic** response to stress. Recent evidence indicates that the behavioral, nervous system, and neuroendocrine responses to stress are mediated by hypothalamic CRF, which acts on both the sympathetic nervous system and the HPA axis, resulting in increased levels of corticosteroids, catecholamines, and certain opiates, substances which are generally immunosuppressive.....

Psychoneuroendocrinology. 1989;14(4):251-74. **Psychoneuroimmunology** for the **psychoneuroendocrinologist**: a review of animal studies of nervous system-immune system interactions. Dunn AJ.
Department of Pharmacology and Therapeutics, Louisiana State University Medical Center, Shreveport 71130-3932.

Evidence for interactions between the nervous and immune systems arises from a number of experimental observations: the behavioral conditioning of immune responses, the effects of stimulation or lesion of brain sites on immune system function, the effects of stressors on immune responses and tumor growth, and physiological and neurochemical changes in the brain during immune responses........

Stress, distress and a variety of psychiatric illnesses, notably the affective disorders, are increasingly reported to be associated with immunosuppression. The concept that psychic distress may predispose to medical illness is centuries old but has only recently attracted the attention of the scientific community at large. Interdisciplinary collaboration has established **psychoneuroimmunology**, or neuroimmunomodulation, as a new field of investigation with the goal of rigorous scientific research into the elusive mind-body connection. This has resulted in the rapid accumulation of information which falls across the boundary lines of psychiatry, immunology, neurosciences and **endocrinology**...

**Psychoneuroimmunology** is a relatively new discipline which deals with CNS-immune system interactions. The evidence for such interactions was reviewed, as was the **neuroendocrinologic** response to stress. Recent evidence indicates that the behavioral, nervous system, and neuroendocrine responses to stress are mediated by hypothalamic CRF, which acts on both the sympathetic nervous system and the HPA axis, resulting in increased levels of corticosteroids, catecholamines, and certain opiates, substances which are generally immunosuppressive.....

Psychoneuroendocrinology. 1989;14(4):251-74. **Psychoneuroimmunology** for the **psychoneuroendocrinologist**: a review of animal studies of nervous system-immune system interactions. Dunn AJ.
Department of Pharmacology and Therapeutics, Louisiana State University Medical Center, Shreveport 71130-3932.

Evidence for interactions between the nervous and immune systems arises from a number of experimental observations: the behavioral conditioning of immune responses, the effects of stimulation or lesion of brain sites on immune system function, the effects of stressors on immune responses and tumor growth, and physiological and neurochemical changes in the brain during immune responses........

Stress, distress and a variety of psychiatric illnesses, notably the affective disorders, are increasingly reported to be associated with immunosuppression. The concept that psychic distress may predispose to medical illness is centuries old but has only recently attracted the attention of the scientific community at large. Interdisciplinary collaboration has established **psychoneuroimmunology**, or neuroimmunomodulation, as a new field of investigation with the goal of rigorous scientific research into the elusive mind-body connection. This has resulted in the rapid accumulation of information which falls across the boundary lines of psychiatry, immunology, neurosciences and **endocrinology**...

Explanation:http://www.ispne.org/journal.html
International Society of Psychoneuroendocrinology (ISPNE)Psychoneuroendocrinology publishes papers dealing with the interrelated disciplines of psychology, neurobiology, endocrinology, immunology, neurology, and psychiatry, with an emphasis on multidisciplinary studies aiming at integrating these disciplines in terms of either basic research or clinical implications.

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