Mac OS X/Safari only: Opening multiple tabs from anywhere except the browser is painful. You click, Safari pops up, head back and repeat. John Gruber has coded a workflow you can install to open multiple URLs with a Control-Click.

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The script, courtesy of Gruber's blog Daring Fireball, only installs on Mac OS X running Snow Leopard (10.6), and can only open tabs in Safari. That said, if you're all-in on your Mac, gaining the ability to launch all the links in any area you select—emails, documents, or PDFs included—without having to make return trips could easily become a daily time saver.

The script is a free download, and the source code, and instructions for building one yourself for Leopard (10.5) are included at the post.