This newly established cooperation opens new windows for bioelectronics research, especially for fabricating flexible and smart devices. In this respect, as a newly developed form of carbon, graphene, has been widely explored in the field of bioelectronics owing to its unique physical and electrochemical properties. Recent advances in graphene research provide various possibilities to enhance performance characteristics and current approaches to design new bio-devices. Especially, smart and flexible bioelectronics on graphene has emerged as a new frontier in this area. Graphene has come to be seen an ideal signal transducer and promising alternative for the production of low cost bioelectronics devices. However, control and regulation on biological systems are always desired for advance applications and productions.