Overview

Biology has become a data-rich science. Modern high-throughput experimental techniques can make simultaneous measurements of vast numbers of biological molecules and their interactions. These measurements can be taken at different times during some biological process, resulting in time-series data. My research group works on the interpretation of these datasets by building predictive models of biological systems using computer algorithms. We have developed methods to uncover the patterns underlying gene expression changes in time and to uncover the complex network of molecular interactions between DNA and proteins which regulate this process. We are also interested in how biological systems change and adapt over much longer evolutionary time-scales using phylogenetic models.

Biography

2012 - Present: Professor of Computational and Systems Biology, Faculty of Life Sciences, University of Manchester

2010 - 2012: Professor of Statistical Bioinformatics and Machine Learning, Sheffield Institute for Translational Neuroscience and Department of Computer Science, University of Sheffield

1998 - 2010: Lecturer and Senior Lecturer in Department of Computer Science, University of Manchester