We report simple particle induced gamma-ray emission (PIGE) methods using 4 MeV proton beam for simultaneous and non-destructive determination of isotopic composition of boron (10B/11B atom ratio) and total boron concentrations in various solid samples with natural isotopic composition and enriched with 10B. It involves measurement of prompt gamma-rays at 429, 718 and 2125 keV from 10B(p,p' g)7Be, 10B(p, p'g)10B and 11B(p, p'g)11B reactions, respectively. Isotopic composition of boron in natural and enriched samples was determined by comparing peak area ratios of 10B and 11B of sample to natural boric acid standard. An in situ current normalized PIGE method, using F or Al, was standardized for total B concentration determination. The methods were validated by analyzing stoichiometric boron compounds and applied to samples like boron carbide, boric acid, carborane and borosilicate glass. Isotopic compositions of boron in the range of 0.247-2.0 corresponding to 10B in the range of 19.8-67.0 atom% and total B concentrations in the range of 5-78 wt% were determined. It has been demonstrated that the PIGE offers simple and alternate method for total boron as well as isotopic composition determination in boron based solid samples including neutron absorbers that are important in nuclear technology.