Prof. Ei-ich Negishis group has reported the Zirconium-Catalyzed Asymmetric Carboalumination of Alkenes (ZACA) reaction. The ZACA catalyst is a prototypical catalyst for asymmetric carbon-carbon bond formation, used for the efficient and selective synthesis of chiral organic compounds and natural products.
Catalyst for:
Carboalumination of alkenes
Asymmetric carboalumination
Intramolecular olefin coupling
Polymerization of propylene
1. Catalyst used for the enantioselective carboalumination of unactivated alkenes.
2. Catalyst used for the enantioselective synthesis of methyl-substituted alkanols and their
derivatives.
3. Reagent for the synthesis of reduced polypropionates via one pot Zr-catalyzed asymmetric
carboalumination Pd-catalyzed cross-coupling tandem process.
4. Catalyst used for the asymmetric carboalumination of internally hydroxylated terminal alkenes