what do you mean by trustworthy? there cannot possibly be an experiment of
lysozyme NTP at 500K....
a "good" simulation will evaporate at this T- but of course it may be
metastable for a while first. that may vary run run to run. all of this
really depends on what you are trying to model. as I said, there is no
experiment to compare to, so what do you want to learn?