The Venom Symbiote's first known host was Spider-Man, who eventually separated himself from the creature when he discovered its true nature. The Symbiote went on to merge with other hosts, most notably Eddie Brock, its second and most infamous host, with whom it first became Venom and one of Spider-Man's archenemies.[2] According to S.H.I.E.L.D., it is considered one of the greatest threats to humanity, alongside Magneto, Doctor Doom, and Red Skull