Immediate effects are only observed above a certain threshold of radiation. These effects are called 'deterministic' because an identical dose will lead to predictable effects. On the whole body level (the effective dose), this threshold has been estimated at 500 mSv. On a more localised level, say the testicles, an equivalent dose of 2 mSv can lead to temporary sterility and 6 mSv can make it permanent. On the skin, a dose of 3-8 Sv leads to a passing redness, 7-10 Sv can raise a boil and anything over 10 Sv will often produce necrosis.