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The 49ers defeated the Cardinals handily last month, dominating Arizona 23-7 in a game that was not nearly that close. Now three weeks later, the 49ers are favored by only four points and many are picking the Cardinals to win outright.

Arizona has won four of its last five, including last week’s overtime victory over the talented Cowboys and the 49ers will face starting quarterback Kevin Kolb this time around. Kolb was out with a foot injury last time and the 49ers limited backup John Skelton to a 10.5 passer rating.

The Cardinals seem to be getting comfortable with defensive coordinator Ray Horton’s varied scheme. Last month, the Cardinals were undisciplined on defense, particularly in the run game.

Arizona is also a physical defense and offensive coordinator Greg Roman admitted this week that the 90 offensive snaps the 49ers executed against the Cardinals took its toll. Roman used it as a reason his offense only mustered two field goals four days later in the 16-6 loss Thanksgiving night in Baltimore.

The Cardinals are not quite in the Lions’ class in terms of being chippy, but they are up there. Three weeks ago at Candlestick, there were more fights on the field than there were in the stands. Part of Arizona’s approach is trying to trash-talk, push and punch the opponent out their game.

The ring leader in most of this is defensive end Darnell Dockett, a universally hated player in the 49ers locker room. His tussles with the equally talkative Anthony Davis bears watching.

In sum, the 49ers may face a stern test in the desert, particularly in Kolb plays well and the Cardinals can make room for running back Beanie Wells.
Possibly the 49ers greatest advantage in this game is with outside pass rushers Ahmad Brooks, Parys Haralson and Aldon Smith against the Cardinals offensive tackles, who are considered two of the worst in the NFL.

Any team facing Arizona must contend with the always dangerous Larry Fitzgerald. This game might be tighter and more entertaining than 49ers fans are used to, particularly in a divisional match-up.