BioPAX pathway converted from "TSFM binds TUFM displacing GDP" in the Reactome database.LEFT-TO-RIGHTTSFM binds TUFM displacing GDPTSFM (EF-Ts, EF-TsMt) acts as a GTP exchange factor to regenerate TUFM:GTP from TUFM:GDP. In the first step of the reaction TSFM binds TUFM:GDP and displaces GDP, yielding a TSFM:TUFM complex (Cai et al. 2000).Authored: May, Bruce, 2014-05-09Reviewed: Chrzanowska-Lightowlers, Zofia M A, 2014-08-29Reviewed: Spremulli, Linda L, 2014-09-20Edited: May, Bruce, 2014-05-09TSFMElongation factor Ts, mitochondrialEFTS_BOVINReactome DB_ID: 5432554mitochondrial matrixGENE ONTOLOGYGO:0005759UniProt:P43896 TSFMTSFMFUNCTION Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.SIMILARITY Belongs to the EF-Ts family.Bos taurusNCBI Taxonomy9913UniProtP4389656EQUAL338EQUALReactome Database ID Release 725432554Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5432554ReactomeR-BTA-54325541Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-5432554.1Reactomehttp://www.reactome.orgTUFM:GDPReactome DB_ID: 5432535TUFMElongation factor Tu, mitochondrialEFTU_BOVINReactome DB_ID: 5432553UniProt:P49410 TUFMTUFMFUNCTION Promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Plays also a role in the regulation of autophagy and innate immunity. Recruits ATG5-ATG12 and NLRX1 at mitochondria and serves as a checkpoint of the RIG-I/DDX58-MAVS pathway. In turn, inhibits RLR-mediated type I interferon while promoting autophagy.SUBUNIT Interacts with NLRX1. Interacts with ATG16L1.SIMILARITY Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.UniProtP4941044EQUAL452EQUALReactome Database ID Release 725432553Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5432553ReactomeR-BTA-54325531Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-5432553.11GDPGuanosine 5'-diphosphateGuanosine diphosphateReactome DB_ID: 113525GDP [ChEBI:17552]GDPGuanosine 5'-diphosphateGuanosine diphosphateChEBICHEBI:17552Reactome Database ID Release 72113525Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113525ReactomeR-ALL-1135252Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-113525.21Reactome Database ID Release 725432535Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5432535ReactomeR-BTA-54325351Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-5432535.1TUFM:TSFMReactome DB_ID: 543248911Reactome Database ID Release 725432489Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5432489ReactomeR-BTA-54324891Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-5432489.1Reactome Database ID Release 725432536Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5432536ReactomeR-BTA-54325361Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-5432536.111045624Pubmed2000Interaction of mammalian mitochondrial elongation factor EF-Tu with guanine nucleotidesCai, Y CBullard, J MThompson, N LSpremulli, L LProtein Sci. 9:1791-80010801827Pubmed2000Interaction of mitochondrial elongation factor Tu with aminoacyl-tRNA and elongation factor TsCai, Y CBullard, J MThompson, N LSpremulli, L LJ. Biol. Chem. 275:20308-14