9 Indeed, patients with congenital dyserythropoietic anemia type I were found to express very high levels of serum GDF15, and this contributed to the inappropriate suppression of hepcidin with subsequent secondary overload. (haematologica.org)

To determine whether hepcidin interacts with Fpn, we generated a stable cell line (HEK293-Fpn) expressing mouse Fpn with a C-terminal green fluorescent protein (GFP) under the control of the ecdysone-inducible promoter. (sciencemag.org)

These results begin to provide insight into fundamental ways in which iron is perturbed in cancer and suggest that the cancer cell has subverted this tightly regulated physiologic pathway to accumulate iron. (aacrjournals.org)

This connection between hepcidin and inflammatory pathways has provided a molecular explanation for the pathophysiology of the anemia of chronic disease, a common and heretofore poorly understood consequence of many common medical conditions, including cancer. (aacrjournals.org)