A villain will say some variation of "resistance is futile." Often, it will turn out resistance was anything but, but villains do like to have their moments. Other common variations are "it is useless to resist us" and "resistance is useless."

A variation of this was used in Words Worth: "Your resistance only makes my penis harder!"

This exact phrase was used in an One Piece fansub, but it is hard to know if it was intentional or the real translation.

During the Retribution Arc in Berserk, one of the pagans who was trying to rape Casca said something akin to this. Boy washe infor it.

Dr Eggman in the third episode of Sonic X give a quote the comes close to the Borg introduction: "I have decided to take over your world and make it part of the new Eggman Empire! Resistance is futile. You will submit to my rule or be swept away like dust bodies!"

Fan Works

In the Empath: The Luckiest Smurf story "Hefty, The Luckiest Smurf", the Psyche Master says this to Empath in the alternate timeline where he is taken back to Psychelia.

N says a variation of "resistance is futile" in Natural Liberated when he finds first Cheren, then Ash, then Rourke. He usually asks "What chance have you against me?", but it delivers the same effect.

A Voice in the Wilderness uses a somewhat different version of the Borg spiel because they've been co-opted by the original Borg Queen, One of One.

"Surrender your vessel. Your technological and biological distinctiveness are immaterial. You will be assimilated into the whole and perfected. I am the Borg. Resistance is futile."

In the 18th chapter of The Vow, Lord Shen duels with Lady Lianne, his prisoner and "former" love interest, telling her at one point that she's fighting an inevitable loss. She is certain that he's referring to something else than the duel.

Vader: You are beaten. It is useless to resist. Don't let yourself be destroyed as Obi-Wan did.

Long before the Borg, the 'Captain' in Cool Hand Luke was giving this exact warning to his inmates.

In The Wolverine, this is the reason why Logan did not join the Japanese freed prisoners that were running away from the explosion that was about to happen, and preferred to stay in his pit. They can't escape from the near-ground zero of an atomic explosion.

"You must able to see it, Mister Anderson, you must know it by now! You can't win, it's pointless to keep fighting!"

In Star Trek: The Motion Picture, after mind-melding with V'Ger, Spock tells Kirk "Any show of resistance would be futile, Captain." What's even more interesting is that V'Ger is said to have come from "a planet populated by living machines with unbelievable technology.", which many theorize to be the Borg homeworld.

"Forget resistance. It is futile. No host has ever overpowered a Yeerk. It is impossible."

In the Warhammer 40,000 novel Fall of Damnos we get this nice message from your usual friendly neighborhood apocalyptic robots next door, "We are the Necrontyr. We are Legion. We Claim Dominion of this World... Surrender and Die. (Note this message was translated by the local Tech Priests, and they insist the last three words were properly translated)

In the British Star Wars parody "Star Bores", the Big Bad is a Dark Lord of the Hith, a group of evil beings with a distinctive lisp. At some point, said Big Bad delivers this gem: "Rethithtanth ith uthelethth!"

Live-Action TV

Our Miss Brooks: Mr. Conklin once uses a variation, when Miss Brooks tries to avoid having him assign some unpaid overtime work.

A Dalek, in "Revelation of the Daleks": "IT IS FUTILE TO RE-SIST". These happen to be its last words.

A Cyberman, in "The Tomb of the Cybermen": "TO STRUGGLE IS FUTILE."

"Resistance is Useless" was a favorite phrase of the Cybermen in their first two stories, "The Tenth Planet" and "The Moonbase." Which actually makes them an Ur-Example (1965), however the phrase is now more commonly associated with the Borg.

The Borg themselves actually derive some of their characteristics from the Cybermen. The original episode featuring the Borg was "Q Who".

An Eternal in "Enlightenment": "Resistance is futile". He was very friendly about it, though.

A Dalek, in "The Stolen Earth": "RESISTANCE IS USELESS."

Subverted with a Dalek, in "Into The Dalek": "RESISTANCE IS FUTILE." The Doctor makes it repeat itself, just to be sure, because it's not saying that resisting the Daleks is futile. It's saying that the Daleksresistinglife is futile.

Played with in "The God Complex": One of the mottos of Tivoli, the Most Conquered Planet in the Galaxy, is "Resistance is exhausting."

Sovereign:"You exist, because we allow it. And you will end, because we demand it."

The Reapers generally see any kind of resistance against them as utterly useless and only delaying the inevitable (not without some justification, admittedly). The one exception is Shepard: they're the one thing in history the Reapers consider an actual threat.

Harbinger: Shepard. You have become an annoyance.

The far too numerous doppelgangers in Baldur's Gate shout this incessantly as you hack them to bits "It is useless to resist!" Since they only have some two battle lines and the latter 3rd of the game consists almost entirely of fighting great wads of them at once you'll be hearing it. A lot.

If you meet a particularly hostile alien race in the original Master of Orion game, they will say "Resistance is futile. The fate of the <your race> is inevitable. Prepare to submit to the <our race> Empire."

This is one of the messages from the Antarans, in the second game, when they're specifically attacking one of your colonies.

Cid Aulstyne: Your Crystal cannot protect you. Resistance is no longer an option. You have six hours. You must comply with our demands, or face the full might of our forces - in which case, I promise you, the roads of Rubrum will run red with the blood of her people.

Bounty Hamster. Cassie and Marion are being chased by a couple of psychotic space slugs with this as their Catch-Phrase. Or maybe not both of them — at one point one slug turns to the other and asks, "What is my line?"

Said by the boss bad guy in Challenge Of The Go Bots after his invasion force had landed on an alien world: "Resistance isn't only futile, it's stupid!"

Of course, The Simpsons has parodied this at least once. In "Lisa The Vegetarian", Lisa's class is forced to watch a film called Meat and You: Partners in Freedom (number 3F03 in the Resistance is Useless Series).

Allura the witch says "resistance is useless" to the Smurfs she has held captive with her Fantastic Drug in her fortress in The Smurfs episode "The Lure of the Orb".

Peridot of Steven Universe paraphrases this when fighting the Crystal Gems- though in a much more frustrated manner than the usual indifference it's delivered with.

"I'm doing this one way or another! You're just making it really difficult!"

The Phalanx in the X-Men cartoon, being expies of the Borg, even used both parts of the Borg catchphrase ("Resistance is futile. You will be assimilated." Though contrary to popular belief, the Borg say "resistance is futile" last.)

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