Manganese superoxide dismutase enzime (Mn-SOD) neutralizes free oxygen radicals forming during inflammation. These participate in the initiation and promotion of carcinogenesis by damaging the DNA, as indicated by the 8-hidroxy-2-deoxigvanosine (8-OHdG) as a sensitive biomarker. The aim of this study was to determine the correlation of the expression of Mn-SOD and 8-OHdG with chronic gastritis, as well as a possible association between the expression and the histopathological diagnosis. The study includes 108 patients distributed in three group:s: group I – 35 patients with moderate chronic gastritis, group II - 35 patients with severe chronic gastritis, group III - 38 patients with regular histology. Except for chronic gastritis, the gastric mucosa bears no evidence of other histopathological changes. The results are Mn-SOD and 8-OHdG-positive in the antrum in 54 (50%) patients and in 18 (16.7%) patients respectively, with both markers most commonly present in patients with severe chronic gastritis (P <0.001; P<0.001). 29 patients (26,9%) were Mn-SOD positive in the corpus, and 10 patients (9,3%) were positive to 8-OHdG, with both markers most commonly indicated in patients with severe chronic gastritis (P <0.001; P<0.001). Also, patients with severe chronic gastritis are often focally positive to Mn-SOD on a wide area in the antrum (P <0.001) and in the corpus (P <0.001). The incidence of patients positive to Mn-SOD and 8-OHdG is substantially higher in cases of severe chronic gastritis, in particular in the antrum (P=0.02; P<0.001) and in the corpus (P=0.03; P<0.002). Equally, in patients with severe chronic gastritis the antrum was substantially more often highly 8-OHdG-positive (P= 0.006), and so was the corpus (P=0.02). By comparing the sensitivity and specificity of the biomarkers it can be concluded that the intensity of antrum-positive Mn-SOD is the best indicator of the difference between patients with regular histologic status and those with moderate and severe chronic gastritis (P<0.001), with a significant discrepancy between areas of positive immunoreactivity to Mn-SOD in the antrum and the corpus for the first two mentioned comparisons (P<0.006; P=0.03). As opposed to this, the best indicator for patients with moderate and severe gastritis is 8-OHdG in the antrum (P<0.001). The determination of antral Mn-SOD, as the best indicator for gastric mucosa inflammation, could be used to single out patients more exposed to the risk of developing stomach cancer, thus enabling an earlier discovery of indicators to initial malignant cell transformation. This, in its turn, might finally enable a timely therapeutic intervention, reduced costs, and presumably better treatment outcomes.