I'm playing a Wolfgang Special, and over these winter months the high E and B strings are getting twangy and fretting out a bit. I've noticed that the two tremolo studs are set at different heights- the one on the high side is a bit lower than the other. If I back that stud out will it correct the problem with the low action on the high strings, and will I need to reset the intonation?

You may have a couple of things going on. Maple necks are pretty solid but depending on where you live the dry cold air could have played havic on your neck. Basically a neck setup and a complete setup at your favorite guitar tech store should solve that problem.

It doesn't sound series so I wouldn't worry. If you're into doing things yourself (neck adjustments I would defer to the pros) you could google the internet to see what self-adjusting you could do.