Center for Proteomics and Bioinformatics

Modern applications of proteomics techniques followed by bioinformatics analyses put the Center for Proteomics and Bioinformatics at the forefront of translational research in the Case Western Reserve University School of Medicine.

Center for Proteomics and Bioinformatics

News and Announcements

$4.6 million from NIH puts CWRU Synchrotron lab on track to become No. 1 in world

Case Center for Synchrotron Biosciences assembles cutting-edge new beamlines at Brookhaven National Laboratory in Upton, N.Y.
Case Western Reserve University's synchrotron facility at Brookhaven National Laboratory is on its way to becoming the No. 1 beamline facility for biology in the world by early 2016, thanks to a jumpstart grant of $4.6 million from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), a component of the National Institutes of Health (NIH).
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Classes - and even degree programs - focused on data analytics are cropping up all over the U.S. Read more at Fortune >>

Structural Biology and Biophysics Training Program (SBB_TP)

The Structural Biology and Biophysics Training Program emphasizes
quantitative methods and equips students to study cell and protein
structure and function using state-of-the-art instrumentation and
computing. The Department hosts outstanding research programs in the areas
of structural biology and cellular ion channels and transporters.

Qualified students receive full tuition waiver, a stipend, and health
benefits during the full duration of their studies.

Students can enter this training program by admission to the
Interdepartmental Structural Biology and Biophysics Training Program
(http://sbb-tp.case.edu).

Research Highlights

Visualizing the kinetic power stroke that drives proton-coupled zinc(ii) transport.

The proton gradient is a principal energy source for respiration-dependent
active transport, but the structural mechanisms of proton-coupled transport
processes are poorly understood. YiiP is a proton-coupled zinc transporter
found in the cytoplasmic membrane of Escherichia coli.
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Organisms of all domains of life use photoreceptor proteins to sense and respond to light. The light-sensitivity of photoreceptor proteins arises from bound chromophores such as retinal in retinylidene proteins, bilin in biliproteins, and flavin in flavoproteins.
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Cross-talk between the ligand- and DNA-binding domains of estrogen receptor

Estrogen receptor alpha (ER.) is a hormone-responsive transcription factor that contains several discrete functional domains, including a ligand-binding domain (LBD) and a DNA-binding domain (DBD). Despite a wealth of knowledge about the behaviors of individual domains, the molecular mechanisms of cross-talk between LBD and DBD during signal transduction from hormone to DNA-binding of ERα remain elusive.
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