PFA is similar to PTFE in chemical resistance and temperature capabilities with continuous operating temperature ratings approaching 500 °F (260 °C). FEP has equal chemical resistance, but continuous operating temperature ratings are lower, on the order of 400 °F (204 °C). Both PFA and FEP, unlike PTFE, can be injection molded.

PVDF is similar to PTFE in that it is resistant to attack from a wide range of chemicals and is able to operate at higher temperatures than most plastics. The range of chemicals it can handle is not as broad as that of PTFE and its continuous operating temperature lower, but it can be injection molded and it is much stronger than PTFE within its operating temperature range. PVDF products can be susceptible to cracking if not properly stress-relieved.