Following her work as production assistant in the costume department of the 1982 documentary The Killing of America, Chamberlin worked as costumer on the drama The Oasis (1984), the horror film The Supernaturals (1986), the thriller The Seventh Sign (1988, with Danna Edwards), and the comedy Sibling Rivalry (1990, with Kirstie Alley and costumer Carol Kunz).

Chamberlin was the costume supervisor on the 1988 war drama A Time of Destiny and started to work as costumer for Whoopi Goldberg in 1993 on the comedy Made in America. Further projects as costumer for Goldberg are the comedy sequel Sister Act 2: Back in the Habit (1993), the drama Boys on the Side (1995), the comedy The Associate (1996), the romance How Stella Got Her Groove Back (1998), the drama The Deep End of the Ocean (1999), the comedy Kingdom Come (2001), and the comedy Rat Race (2001).

Other projects as costumer include the comedy Stuart Saves His Family (1995), the comedy Miss Congeniality (2000, with Deborah Hall), as costumer for Ben Stiller on the comedy Envy (2004), the comedy The Last Shot (2004), the comedy Christmas with the Kranks (2004, with Deborah Hall and Dennis McCarthy), the romance The Ugly Truth (2009), and the television series The Oaks (2008) and Private Practice (2010).