Former Biarritz prop Campbell Johnstone will make his debut for an injury-ravaged Ospreys who include internationals Alun Wyn Jones, Adam Jones and Aaron Jarvis among their absentees. Fly-half Dan Biggar starts having recovered from a shoulder injury.

Zebre v Harlequins

Saturday, 1.35pm, Sky Italia Harlequins are boosted by the return of England pair Mike Brown and Danny Care who start at full-back and scrum-half respectively. Ugo Monye and Ben Botica have recovered from injuries and have been named among the replacements.

Zebre include wing Giovanbattista Venditti, fly-half Luciano Orquera and lock Quintin Geldenhuys who played for Italy in their narrow defeat by Australia in Firenze two weeks ago.

Sale v Toulon

Saturday, 3.40pm, Sky Sp 1 Former England prop Andrew Sheridan returns to Sale as part of a star-studded Toulon side that also includes Delon and Steffon Armitage, Jonny Wilkinson, Bakkies Botha and Matt Giteau.

Sale have kept Rob Miller at fly-half with Danny Cipriani, who was ill last week, rejoining the squad as a replacement. James Gaskell is preferred to Andy Powell in the back row and Will Cliff starts at scrum-half instead of the injured Dwayne Peel (shoulder).

Munster v Saracens

Saturday, 6pm, Sky Sp 1 Munster give a first start in the competition to blindside flanker Dave O’Callaghan in the absence of the injured Niall O’Ronan, Sean Dougall and Tommy O’Donnell. Number eight James Coughlan returns after recovering from a groin tear.

Saracens have centres Owen Farrell and Brad Barritt, wing Chris Ashton, full-back Alex Goode and prop Mako Vunipola back from England duty. Vunipola has to settle for a place on the bench. Number eight Ernst Joubert makes his 100th appearance.

Racing Metro v Edinburgh

Saturday, 6pm, Sky Sports 1 red button Edinburgh, who won in Paris last season, make four changes to their pack with internationals John Yapp, Ross Ford and Geoff Cross forming a new front row. Lock Grant Gilchrist is recalled.

Racing Metro have kept faith with ten of the side that beat Stade Francais in last weekend’s Top 14 Paris derby including former Bath and England fly-half Olly Barkley.

Former Scotland No 8 Johnnie Beattie is one of only five survivors from the Montpellier side who beat Bayonne last week. Former England centre Shontayne Hape, a summer signing from London Irish, is on the bench but faces a late fitness test.

Clermont, unbeaten at home since November 2009, have made 11 changes to the side beaten at Toulouse last week. Captain Aurelien Rougerie, Alexandre Lapandry, Nathan Hines and Jamie Cudmore are the only survivors.