eDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London W2 1PG, United Kingdom;fMedical Research Council-Public Health England Centre for Environment and Health, Imperial College London, London W2 1PG, United Kingdom;

tCentre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh EH8 9JZ, United Kingdom;uCentre for Genomic and Experimental Medicine, University of Edinburgh, Edinburgh EH4 2XU, United Kingdom;

ggDepartment of Twin Research and Genetic Epidemiology, King’s College, London SE1 7EH, United Kingdom;hhNational Institute for Health Research Biomedical Research Centre at Guy’s and St. Thomas’ Foundation Trust, London SE1 9RT, United Kingdom;

iiCenter for Public Health Genomics, Department of Public Health Sciences, University of Virginia, Charlottesville, VA 22903;jjBiostatistics Section, Department of Public Health Sciences, University of Virginia, Charlottesville, VA 22903;

eDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London W2 1PG, United Kingdom;llInstitute of Health Informatics, University College London, London NW1 2DA, United Kingdom;mmFarr Institute of Health Informatics Research, University College London Institute of Health Informatics, London NW1 2DA, United Kingdom;

tCentre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh EH8 9JZ, United Kingdom;xxAlzheimer Scotland Research Centre, University of Edinburgh, Edinburgh EH8 9JZ, United Kingdom;

eDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London W2 1PG, United Kingdom;iiiDepartment of Cardiology, Ealing Hospital, Middlesex UB1 3HW, United Kingdom;

eDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London W2 1PG, United Kingdom;iiiDepartment of Cardiology, Ealing Hospital, Middlesex UB1 3HW, United Kingdom;jjjImperial College Healthcare National Health Service Trust, London W12 0HS, United Kingdom;

oCNRS UMR 8199, Lille Pasteur Institute, European Genomic Institute for Diabetes, Lille 2 University, 59000 Lille, France;rrrDepartment of Genomics of Common Disease, School of Public Health, Imperial College London, London W12 0HR, United Kingdom;

eDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London W2 1PG, United Kingdom;xxxUnit of Primary Care, Oulu University Hospital, 90220 Oulu, Finland;bbbbCenter for Life Course Epidemiology, Faculty of Medicine, University of Oulu, Oulu FI-90014, Finland;ccccBiocenter Oulu, University of Oulu, Oulu FI-90014, Finland;

sInstitute for Molecular Medicine, University of Helsinki, 00290 Helsinki, Finland;aaNational Institute for Health and Welfare, 00271 Helsinki, Finland;ddDepartment of Public Health, University of Helsinki, 00014 Helsinki, Finland;

zUsher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh EH8 9AG, United Kingdom;fffDepartment of Medical Sciences, University of Trieste, 34149 Trieste, Italy;

eDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London W2 1PG, United Kingdom;fMedical Research Council-Public Health England Centre for Environment and Health, Imperial College London, London W2 1PG, United Kingdom;uuuuDepartment of Hygiene and Epidemiology, University of Ioannina Medical School, 45110 Ioannina, Greece;

dddDepartment of Cardiology, University Medical Center Groningen, University of Groningen, 9700RB Groningen, The Netherlands;vvvvDepartment of Genetics, University Medical Center Groningen, University of Groningen, 9700RB Groningen, The Netherlands;wwwwDurrer Center for Cardiogenetic Research, Interuniversity Cardiology Institute of The Netherlands–Netherlands Heart Institute, 3511GC Utrecht, The Netherlands;

zUsher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh EH8 9AG, United Kingdom;eeeMedical Research Council Human Genetics Unit, Institute for Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, United Kingdom;

eDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London W2 1PG, United Kingdom;uuuuDepartment of Hygiene and Epidemiology, University of Ioannina Medical School, 45110 Ioannina, Greece;

eDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London W2 1PG, United Kingdom;fMedical Research Council-Public Health England Centre for Environment and Health, Imperial College London, London W2 1PG, United Kingdom;