Abstract

Background. Early detection to predict neurodevelopmental disorders in early infancy is
difficult. Hyperbilirubinemia is one of the major cause of neurodevelopmental disorders leads to
developmental delayed. General movements(GMs) is a sensitive tool to evaluate brain function
in young infants.
Objective. To determine the risk factor of neonatal hyperbilirubinemia to predict abnormal
general movements.
Method. A Cohort research was conducted in 44 neonates in Dr Kariadi Hospital in September
2009-Februari 2010, 22 neonates with BIS > 12 mg/dl and 22 neonates with IBS < 12 mg/dl,
both taken with consecutive sampling method, after three months the infants were recorded
according to Precthl method. Each recording was analyzed by means of Gestalt perception of the
expert. Grouping to normal and abnormal GMs based on Likert scale. Abnormal GMs if the
score was ≤ 5. Chi-square test, Receiver Operating Curve and multivariat logistic regression
analysis were done.
Results. Mean IBS level of subject with abnormal GMs risk was 15,6 mg/dL, 15 (34,09%)
subjects had abnormal GMs. Receiver Operating Curve (ROC) showed IBS level could be used
as outcome predictor for abnormal GMs in young infants, with IBS cut-off point 12.67 mg/dL.
IBS level > 12 mg/dL were risk factor 28,4x leads to abnormal GMs. There was a significant
correlation between neonatal BIS Level and the risk of abnormal GMs in young infants.
Conclusion. Neonatal hyperbilirubinemia were risk factor 28,4x leads to abnormal GMs and the
IBS cut-off point is 12.67 mg/dL.
Key word : general movements, hyperbilirubinemia.