Not unless the mixer has 4 line level outs, plus an ADAT/Lightpipe out. You might want to look into an M-Audio Octane. It's an 8 channel pre-amp that has an ADAT out. I installed one to good effect in a community college t augment an LE system. It worked great. That would at least give you 12 channels. Add in a mixer that has 4 line level outs, and you would have your 16 channels of record.