Author

Abstract

Background: A decline in the age of menarche was observed
from early 1900s to the 1970s. However, it is not known if a further decline ocurred thereafter.
Aim: To evaluate the age of menarche in girls from Santiago, Chile and its relationship with
body mass index (BMI) and socioeconomic status. Material and Methods: We studied 1302
healthy girls aged 7 to 19 years. Age of menarche was evaluated through a questionnaire to the
patient and her parents. Kaplan-Meier curves were used to determine age of menarche and Cox
regression analysis was employed to evaluate the effect of the type of school and BMI on the age
of menarche. Results: The mean age at menarche was 12.7±0.04 years. Girls from public and
private schools had their period at 12.5±0.1 and 13.05±0.05 years respectively. A negative
correlation between z scores for BMI and age of menarche was observed (r-0.3: p =0.001). Girls
whose menarche occurred before 11.5 years had higher z scores for BMI and a larger
proportion were overweight, compared to girls who had menarche later. Cox regression analysis
showed that after adjusment for BMI, age of menarche was similar in both types of schools.
Conclusions: Age of menarche is ocurring three months earlier in girls from public schools,
which is associated with higher z scores for BMI. Type of school, a marker of socio-economic
status in Chile, affects timing of menarche due to differences in body mass index.