Fusion

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Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:query proteins and first shell of interactors

white nodes:second shell of interactors

Node Content

empty nodes:proteins of unknown 3D structure

filled nodes:some 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

Psed_1189

Amidohydrolase (301 aa)

Predicted Functional Partners:

smpB

SsrA-binding protein; Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a "tag peptide", a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to [...] (161 aa)

SsrA-binding protein; Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a "tag peptide", a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to [...]

0.552

Psed_1186

Psed_1184

Psed_1186

Psed_1184

Cell division ATP-binding protein FtsE

PadR family transcriptional regulator

0.735

Psed_1186

Psed_1187

Psed_1186

Psed_1187

Cell division ATP-binding protein FtsE

Hypothetical protein; Part of the ABC transporter FtsEX involved in cellular division

SsrA-binding protein; Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a "tag peptide", a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to [...]

0.790

Psed_1187

Psed_1184

Psed_1187

Psed_1184

Hypothetical protein; Part of the ABC transporter FtsEX involved in cellular division

PadR family transcriptional regulator

0.626

Psed_1187

Psed_1186

Psed_1187

Psed_1186

Hypothetical protein; Part of the ABC transporter FtsEX involved in cellular division

Cell division ATP-binding protein FtsE

0.975

Psed_1187

Psed_1189

Psed_1187

Psed_1189

Hypothetical protein; Part of the ABC transporter FtsEX involved in cellular division

Amidohydrolase

0.767

Psed_1187

prfB

Psed_1187

Psed_1185

Hypothetical protein; Part of the ABC transporter FtsEX involved in cellular division

Hypothetical protein; Part of the ABC transporter FtsEX involved in cellular division

SsrA-binding protein; Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a "tag peptide", a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to [...]

0.840

Psed_1189

Psed_0486

Psed_1189

Psed_0486

Amidohydrolase

Glyoxalase/bleomycin resistance protein/dioxygenase

0.569

Psed_1189

Psed_0588

Psed_1189

Psed_0588

Amidohydrolase

Helix-turn-helix domain-containing protein

0.592

Psed_1189

Psed_1184

Psed_1189

Psed_1184

Amidohydrolase

PadR family transcriptional regulator

0.544

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Network Stats

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Functional enrichments in your networkNote: some enrichments may be expected here (why?)

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Statistical background

For the above enrichment analysis, the following statistical background is assumed: