TRAF-2 Antibody Summary

Immunogen

This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to an internal region human TRAF2.

Specificity

The product was affinity purified from monospecific antiserum by immunoaffinity chromatography. This antibody is predicted to react with TRAF2 from human and mouse sources based on a 100% identity with the immunizing sequence. Reactivity with TRAF2 from other sources has not been determined.

Clonality

Polyclonal

Host

Rabbit

Gene

TRAF2

Purity

Immunogen affinity purified

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Reactivity Notes

Packaging, Storage & Formulations

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Buffer

0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Preservative

0.01% Sodium Azide

Concentration

LYOPH

Purity

Immunogen affinity purified

Reconstitution Instructions

Reconstitute with 50 ul of distilled water to a final concentration of 1.0 mg/ml.

Alternate Names for TRAF-2 Antibody

E3 ubiquitin-protein ligase TRAF2

EC 6.3.2.-

MGC:45012

TNF receptor-associated factor 2

TRAF2

TRAF-2

TRAP3

TRAP3TRAP

tumor necrosis factor type 2 receptor associated protein 3

Tumor necrosis factor type 2 receptor-associated protein 3

Background

TRAF2, or Tumor Necrosis factor (TNF) Receptor-Associated Factor 2, is an adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. Association to the receptor is also mediated by the interaction with TRADD. TRAF2 mediates activation of NF-kappa-B and MAPK8/JNK and is involved in apoptosis. TRAF2 forms a heterodimeric complex with TRAF1, which then recruits the inhibitor-of-apoptosis proteins (IAPs), apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2 for the inhibition of caspase activation. In this way it functions as a mediator of the anti-apoptotic signals from TNF receptors. BIRC2/c-IAP1, an apoptosis inhibitor possessing ubiquitin ligase activity, can unbiquitinate and induce the degradation of this protein, and thus potentiate TNF-induced apoptosis. TRAF2 may be involved in IL-15 signaling. Multiple alternatively spliced transcript variants exist, but the biological validity of only one transcript has been determined.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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