1,3,5-triazine substrate exhibit a broad spectrum of biological activities as herbicides, analgesic and enzyme inhibitors. In this thesis, two solid phase strategies leading to the facile assembly of derivatives of 1,3,5-triazines will be discussed. During the syntheses, sulfur linker was used and the triazine substrates were released via either microwave assisted cleavage or safety catch cleavage or Liebeskind Srogl coupling conditions to release the corresponding triazine analogues. Representative members from traizine libraries were subjected to biological assay to evaluate the potential of 1, 3, 5-traizine substrate as inhibitors of neuronal nitric oxide synthase.