Profluthrin

Profluthrin (2,3,5,6-tetrafluoro-4-methylbenzyl (EZ)-(1RS,3RS;1RS,3SR)-2,2-dimethyl-3-prop-1-enylcyclopropanecarboxylate, CAS#223419-20-3),
a newly discovered insecticide, provides high efficacy against fabric pests
and also has relatively high vapor pressure and low mammalian toxicity, which means
Profluthrin has various superior properties as an active ingredient of moth proofers. In addition, it has excellent
activity against sanitary pests like flies, mosquitoes and cockroaches. Profluthrin was launched in 2004 in Japan,
and several companies have adopted it for their household insecticide products. In this report we will introduce
he outline of the new synthetic pyrethroid Profluthrin.

Uses

The lethal effects of profluthrin on Tineola
bisselliella, inea translucens and Attagenus unicolor lar vae were
as llows, respectively: approximately four times greater, ore than
five times greater and approximately eight mes greater than that of
EZ-empenthrin.

Profluthrin demonstrated efficacy againstTineola
bisselliella and Tinea translucens lar vae by a factor of
approximately four times greater than that of EZ-empenthrin. It also showed high efficacy against Attagenus
unicolor lar vae which was approximately eight times
greater than that of EZ-empenthrin. It has
therefore been revealed that profluthrin possesses high
vapor action against the lar vae of fabric pests.

When using profluthrin as an active ingredient for
moth-proofing products, such products will be used in
carton cases, drawers and wardrobes that contain cloth-ing. Therefore, several efficacy tests were conducted in
such practical conditions.

(1) Egg-Hatching Inhibition Effect in a Drawer Test
The practical efficacy of each test sample was evalu-ated, assuming usage in carton cases and drawers,
through the following procedure: Filter papers impreg-nated with agent were placed in a carton case containing
clothes (with an approximate capacity of 50 L); and the
effect of the test sample on Tineola bisselliella eggs was
obser ved each time a specific time inter val had passed.

Profluthrin demonstrated high efficacy (egg-hatching
inhibition effect and lethal effect on newly hatched lar -
vae) against Tineola bisselliella eggs under a dosage of
20 mg during the period from one to six months after the initiation of the test. This result was nearly equivalent to
that of a fivefold quantity of EZ-empenthrin and signifi-
cantly greater than that of 80 g of p -dichlorobenzene.

(2) Egg-Hatching Inhibition Effect in a Wardrobe Test
Assuming the use in wardrobes, the practical efficacy
of each agent against Tineola bisselliella was evaluated
using a wardrobe.

Profluthrin demonstrated pest-control rates of
100%
egg-hatching inhibition and lethal rate of newly hatched
ar vae) against Tineola bisselliella eggs under a dosage
of 0.1g during the period from one to six months after
he initiation of the test.
This result was equivalent to that of a fivefold quantity
of EZ-empenthrin. On the contrar y, p -dichlorobenzene
did not show sufficient efficacy during the period from the
initiation of the test until six months after the test,
even with a dosage of 120 g.

(3) Oviposition Inhibition Effect on Fabric Pests
Worm-hole damage can be caused by the larvae of
fabric pests through the following process: The adults
of Tinea translucens, Tineola bisselliellaand Attagenus
unicolor fly into houses, enter drawers and wardrobes,
lay eggs on clothing, and finally the hatched lar vae feed
on fabrics. For this reason the insecticidal activity
against such lar vae and egg-hatching inhibition effect
on eggs laid on clothes were conventionally considered
important evaluation criteria. However, it can be
assumed that it is also important to prevent the adults
of fabric pests from coming into contact with clothing
and/or laying eggs in order to prevent worm-hole
damage. Therefore, the oviposition inhibition effect of
profluthrin on those adults was evaluated in a 28m3
test
chamber using a wardrobe with a capacity of approxi-mately 700 L.

Profluthrin possesses high efficacy not only
against
fabric pests but also sanitar y pests (houseflies, mos-quitoes,
cockroaches) and nuisance pests (moth flies,
fruit flies).
(1) Lethal Effects on Sanitar y Pests
The lethal effect of profluthrin against various sani-tar y pests
was investigated by a topical application
method and compared with that of EZ-empenthrin.
Profluthrin showed a high lethal effect on the adults of
Culex pipiens pallens, Culex pipiens molestus and Aedes
albopictus, and its relative insecticidal activity was
ap-proximately ten to twenty times greater than that of
EZ-empenthrin. However, the lethal effect of profluthrin
against Musca domesticaadults was nearly equal to that
of EZ-empenthrin, while its lethal effect against Blat-tella
germanica adults was slightly greater than that of
EZ-empenthrin.

(2) Efficacy against Mosquitoes in a Glass Chamber
Test
The knockdown effects of profluthrin against various
species of mosquitoes were observed in a glass chamber
with a capacity of 0.34 m3
and compared to those of EZ-empenthrin. The following procedures were
undertaken to obser ve the knockdown effects: A piece
of filter paper impregnated with each test sample was
suspended from the ceiling of the chamber. The test in-sects (adults) were then released into the chamber. The
number of knocked-down insects was counted each time
the specified time inter val had elapsed, and the time re-quired for knocking down half of the test insects (KT 50)
was measured.
Profluthrin, vaporizing under ambient temperature,
demonstrated excellent fast-acting efficacy against the
adults of Culex pipiens molestus and Aedes albopictus . It
also showed a knockdown effect greater than that of EZ-empenthrin with just one-fourth the dose.

(3) Efficacy against Nuisance Pests by Vapor Action
Test
To investigate the vapor action of profluthrin against
nuisance pests, the vapor action test was conducted in a
small space under ambient temperature and compared
to the vapor action of EZ-empenthrin. Adults were re-leased into a 200 mL plastic cup, the top of which was
covered with a net in order to prevent the insects from
directly coming into contact with the treated surface.
The cup was then placed upside down on the treated alu-minum plate. Lastly, the number of knocked-down in-sects was counted each time the specified time inter val
had elapsed.

Profluthrin showed excellent knockdown effects on
Clogmia albipunctata and Drosophilamelanogaster adults,
which were much greater than those for the equivalent
amount of EZ-empenthrin.

Package & Transport

Notice

1. Avoid mixture with food and forage, and avoid reach of children.
2. Use respirator and glove when handling, clean completely with soap and water when splashed into skin.
3. Destroy and bury waste drum or dip it into alkali liquid for several days for recycling uses.
4. Storage in dry, cold area and avoid light.