Monosodium Glutimate (MSG), has gotten a bad rap for more than 50 years, but should that negative reputation be reconsidered? Reactions, a video series produced by the American Chemical Society, breaks down the science to find out. (Reactions via YouTube)

Monosodium Glutamate (MSG), an additive best known for its use in Chinese restaurants, has had the thumbs up from scientists for quite some time now. But consumers still think of it as dangerous, and many claim to have bad reactions to it. So what's the deal?

As explained in the above video by the American Chemical Society (and in this infographic by Compound Interest), the now-maligned MSG was first isolated from seaweed in Japan in 1908. It doesn't produce a flavor on its own, but it boosts the tongue's perception of certain flavors - "umami" in particular - that are already present in the food.

MSG got a bad rap when a scientist coined the term "Chinese Restaurant Syndrome" in a letter to The New England Journal of Medicine. Robert Ho Man Kwok experienced heart palpitations, weakness, and strange sensations of numbness after eating large amounts of Chinese food, and his colleagues decided that MSG must be the culprit. Today, many restaurants label their food as "No MSG" to appease the individuals who claim to experience these symptoms when they consume the compound.

Here's the thing: Natural glutamate occurs in many foods, and is used as an additive in tons of "MSG-free" products. And don't even get me started on the "umami" craze - anything that claims to have umami flavor is probably using natural glutamate, and tons of it. But because of the chemical similarity to MSG, there's no reason why eating a fancy umami burger should be any better for the MSG-sensitive crowd than eating a bowl of fried rice.

It's true that an early study found that mice suffered ill effects when researchers injected MSG into their brains, but these results fall under the heading of "there's such a thing as too much of a good thing, especially when you inject it into a mouse's brain." Human studies have failed to produce significant symptoms, even in those who claim to suffer. Scientists report that mild symptoms can occur in some individuals, but only if they consume large amounts of MSG on an empty stomach. If you avoid scarfing down cup noodles when you're starving, you should be just fine.

Comments our editors find particularly useful or relevant are displayed in Top Comments, as are comments by users with these badges: . Replies to those posts appear here, as well as posts by staff writers.

To pause and restart automatic updates, click "Live" or "Paused". If paused, you'll be notified of the number of additional comments that have come in.

Comments our editors find particularly useful or relevant are displayed in Top Comments, as are comments by users with these badges: . Replies to those posts appear here, as well as posts by staff writers.