dose

dose

the quantity to be administered at one time, as a specified amount of medication or a given quantity of radiation.

absorbed dose that amount of energy from ionizing radiations absorbed per unit mass of matter, expressed in rads.

air dose the intensity of an x-ray or gamma-ray beam in air, expressed in roentgens.

booster dose an amount of immunogen (vaccine, toxoid, or other antigen preparation), usually smaller than the original amount, injected at an appropriate interval after primary immunization to sustain the immune response to that immunogen.

curative dose (CD) a dose that is sufficient to restore normal health. See also median curative dose.

maximum permissible dose the largest amount of ionizing radiation that one may safely receive within a specified period according to recommended limits in current radiation protection guides. The specific amounts vary with age and circumstance.

median curative dose (CD50) a dose that abolishes symptoms in 50 per cent of test subjects.

median effective dose (ED50) a dose that produces the desired effect in 50 per cent of a population.

median infective dose (ID50) that amount of pathogenic microorganisms that will produce demonstrable infection in 50 per cent of the test subjects.

median lethal dose (LD50) the quantity of an agent that will kill 50 per cent of the test subjects; in radiology, the amount of radiation that will kill, within a specified period, 50 per cent of individuals in a large group or population.

median tissue culture infective dose (TCID50) that amount of a pathogenic agent that will produce infection in 50 per cent of cell cultures inoculated.

minimum lethal dose

1. the amount of toxin that will just kill an experimental animal.

2. the smallest quantity of diphtheria toxin that will kill a guinea pig of 250-gm weight in 4 to 5 days when injected subcutaneously.

reference dose an estimate of the daily exposure to a substance for humans that is assumed to be without appreciable risk; it is calculated using the no observed adverse effect level and is more conservative than the older margin of safety.

skin dose (SD)

1. the air dose of radiation at the skin surface, comprising the primary radiation plus backscatter.

lethal dose that quantity of an agent that will or may be sufficient to cause death.

maximum dose the largest dose consistent with safety.

maximum permissible dose (MPD) the largest amount of ionizing radiation that one may safely receive in a specified period according to recommended limits in radiation protection guides.

median curative dose (CD50) a dose that abolishes symptoms in 50 per cent of test subjects.

median effective dose (ED50) a dose that produces the desired effect in 50 per cent of a population.

median immunizing dose the dose of vaccine or antigen sufficient to provide immunity in 50 per cent of test subjects.

median infective dose (ID50) the amount of pathogenic microorganisms that will cause infection in 50 per cent of the test subjects.

median lethal dose (LD50) the quantity of an agent that will kill 50 per cent of the test subjects; in radiology, the amount of radiation that will kill, within a specified period, 50 per cent of individuals in a large group or population.

median toxic dose (TD50) the dose that produces a toxic effect in 50 per cent of the population.

minimum dose the smallest dose that will produce an appreciable effect.

minimum lethal dose (MLD)

1. the smallest amount of toxin that will kill an experimental animal.

2. the smallest quantity of diphtheria toxin that will kill a guinea pig of 250 g weight in 4 to 5 days when injected subcutaneously.

skin dose (SD)

1. the air dose of radiation at the skin surface, comprising primary radiation plus backscatter.

2. the absorbed dose in the skin.

threshold dose the minimum dose of ionizing radiation, a chemical, or a drug that will produce a detectable degree of any given effect.

threshold erythema dose the single skin dose that will produce in 80 per cent of those tested a faint but definite erythema within 30 days, and in the other 20 per cent, no visible reaction. Abbreviated T.E.D.

tolerance dose the largest quantity of an agent that may be administered without harm.

dose

(dōs)

n.

1.

a. A specified quantity of a therapeutic agent, such as medicine, prescribed to be taken at one time or at stated intervals.

b. The amount of radiation administered as therapy to a given site.

2. Slang A venereal infection.

tr.v.dosed, dosing, doses

1. To give (someone) a dose, as of medicine.

2. To give or prescribe (medicine) in specified amounts.

dos′er n.

dose

[dōs]

Etymology: GK, didonai, to give

the amount of a drug or other substance to be administered at one time. See also absorbed dose. Compare dosage.

dose

The amount of drug administered to a subject/patient at one time, or the total quantity administered.

dose

A quantity of a substance, medication, or radiation that is administered or absorbed during a specific time period Occupational medicine The total amount of a toxicologically relevant material reaching the target site over a specific time period; determination of dose requires information on the agent, its concentration, the form of the agent–eg aerosol, topical, ingested, length of exposure, and weight of person exposed. See MSDS Radiation oncology The concentration of energy divided by the tissue mass of energy deposited by radiation in the body, measured in grays–formerly, rads. See Effective dose, Gray Therapeutics The amount of medicine taken. See Absorbed dose, Effective dose, Equivalent dose, Genetically significant dose, Imputed dose, Law of infinitesimal dose, Lethal dose, Loading dose, Maintenance dose, Maximum tolerable dose, Median lethal dose, Minimum lethal dose, Occupational dose, Organ dose, Overdose, Pharmacologic dose, Ramped dose, Reference dose, TCID.

dose

(dōs)

1. The quantity of a drug or other remedy to be taken or applied all at one time or in fractional amounts within a given period. usage note Sometimes incorrectly used fordosage. Compare: dosage (2)

dose

1. A stipulated quantity of a drug to be taken once or at stated intervals.

2. The amount of radiation received or administered.

dose

the known amount of chemical or other treatment received by an organism.

dose

quantity of drug (e.g. in milligrams) to be taken within a given time span

dose,

n1. a specific quantity of a therapeutic substance. 2. a specific amount of radiation received by an organism.

dose equivalent,

n number used in radiation safety that is the product of the radiation dose absorbed by a tissue multiplied by a given quality factor specific to the type of radiation used. Expressed in sieverts or rems, dose equivalent is used to determine potential physical injury to the patient.

dose, carbohydrate challenge,

n a measured quantity of lactulose or glucose taken as part of a breath test used to detect bacterial overgrowth in the small intestine. Bacteria are detected by increased hydrogen and methane in the breath resulting from fermentation of the carbohydrate administered.

dose, effective,

n dose that produces sufficient or the best results.

dose, infinitesimal,

n homeopathic remedy, the source material of which is diluted past the Avogadro's number and therefore is not likely to have the original remaining constituent. See also ultrahigh dilution.

dose, lethal,

n in animal-based product testing, the amount of test product required for 50% of the test subjects to die.

n according to the guidelines for radiation protection for persons working with x-rays or radioactive materials, the maximum ionizing radiation that can be received by a person. Also called effective dose equivalent unit or MPD.

n the amount of a substance that, when administered to a group of experimental animals, is expected to kill 50% of the population within a given time.

dose, median toxic,

n the amount of a substance that is expected to produce toxic effects in 50% of the patients to whom it is administered.

dose, minimum,

n in homeopathy, the highest dilution of a remedy that has curative properties without undesirable side effects elicited at higher concentrations.

dose, minimum lethal,

n in relation to the body weight, the smallest amount of a substance that will kill an experimental animal. Also called minimum fatal dose or MLD.

dose, no-effect,

n the largest amount of a substance that induces no effects in cells or organisms.

dose, safe,

n the maximum dose of a medicinal substance that can be administered without producing deleterious side effects.

dose, single,

n the theory of giving only one dosage at a time. Depending on the type of homeopathy, the dose could be later repeated, or different remedies could be given. Unicist homeopathy is founded on this concept. See also homeopathy, complex and homeopathy, pluralist.

dose, therapeutic,

n the dose of a medicinal substance necessary to produce the desired ameliorative effects.

doses, ultra-low,

n.pl amounts of medicinal substances that are a fraction of their normal concentration.

dose

(dōs) Do not confuse this word with dosage.

Quantity of drug or other remedy to be taken or applied at once or in fractional amounts within a given period.

[G. dosis, a giving]

dose,

n1. the quantity of drug necessary to produce a desired effect.n2. the total radiation delivered to a specified area or volume or to the whole body. See also dose, radiation-absorbed.

dose, absorbed (D),

n the amount of energy imparted by ionizing particles to unit mass of irradiated material at a place of interest. The unit of absorbed dose is the rad (100 ergs/Gm).

dose, air,

n a radiographic dose delivered at a point in free air; expressed in roentgens. It consists only of the radiation of the primary beam and the radiation scattered from surrounding air; does not include backscatter from radiated matter (e.g., tissue).

dose, booster,

n the portion of an immunizing agent given at a later time to stimulate the effects of a previous dose of the same agent.

dose, cumulative

(kū´myələtiv), n the total accumulated dose resulting from a single or repeated exposure to radiation of the same region or of the whole body. If used in area monitoring, it represents the accumulated radiation exposure over a given period.

dose, depth,

n the absorbed dose of radiation imparted to matter at a particular depth below the surface, usually expressed as “percentage depth dose.” See also dose, percentage depth.

dose, distribution,

n a representation of the variation of dose with position in any region of an irradiated object. The dose distribution may be measured using detectors small enough to avoid disturbing the distribution, or it may be calculated and expressed in mathematical form.

dose, doubling,

n the amount of ionizing radiation, absorbed by the gonads of the average person in a population over a period of several generations, that will result in a doubling of the current rate of spontaneous mutations.

n the product of absorbed dose and modifying factors, namely the quality factor (QF), distribution factor (DF), and any other necessary factors. The unit of dose equivalent is the rem (rads times qualifying factors).

dose, erythema

(erəthē´mə), n the dose of radiation necessary to produce a temporary redness of the skin. This dose varies with the quality of radiation.

dose, exit,

n the absorbed dose delivered by a beam of radiation at the surface through which the beam emerges from a phantom or patient.

n a dose given by a number of shorter exposures over a longer period than would be required if the dose was given by a continuous exposure in one session at the same dose rate.

dose, gonadal,

n the dose of radiation absorbed by the gonads.

dose, integral (integral absorbed dose, volume dose),

n the total energy absorbed by a part or object during exposure to radiation. The unit of integral dose is the gram rad (100 ergs/gm).

dose, lethal,

n1. the amount of a drug that would prove fatal to the majority of persons.n2. the amount of radiation that will be or may be sufficient to cause the death of an organism.

dose, maintenance,

n the quantity of drug necessary to sustain a normal physiologic state or a desired blood or tissue level of drug.

dose, maximum permissible (MPD),

n the maximum relative biologic effect dose that the body of a person or specific parts thereof shall be permitted to receive in a stated period. In most instances, for the roentgen rays used in dental radiography, it is satisfactory to consider the RBE dose in rems numerically equal to the absorbed dose in rads and the absorbed dose in rads numerically equal to the exposure dose in roentgens. See also dose, weekly permissible.

dose, median effective (ED50),

n a dose that, under standard conditions, is effective in 50% of a randomly selected group of subjects.

dose, median lethal (LD50),

n the amount of ionizing radiation required to kill, within a specified period, 50% of the individuals in a large group or population of animals or organisms.

dose, minimum lethal (MLD),

n the minimal amount of a drug that will kill an experimental animal.

dose, percentage depth,

n the ratio (expressed as a percentage) of the absorbed dose at a given depth in an irradiated body, to the absorbed dose at a fixed reference point on the central ray, usually the surface-absorbed dose.

dose, priming,

n a quantity several times larger than the maintenance dose; used at the initiation of therapy to rapidly establish the desired blood and tissue levels of the drug.

dose, protraction

(prōtrak´shən), n a method of radiation administration delivered continuously over a relatively long period at a relatively low dosage rate.

dose, radiation,

n the amount of energy absorbed per unit mass of tissue at a site of interest. Note: This definition limits the use of “dose” to conform with the 1962 recommendations of the International Commission on Radiological Units and Measurements (ICRUM). The following terms therefore become obsolete but will be found in this dictionary under the general heading of exposure: air dose, cumulative dose, exposure dose, and threshold dose.

dose, radiation-absorbed (rad),

n the unit of absorbed dose, with a value of 100 ergs per gram.

dose, rate,

n the time rate at which radiation dose is applied, expressed in either roentgens per unit time or rads per unit time.

dose, safely tolerated (STD),

n the dose that can be safely tolerated without producing serious acute toxicity.

dose, skin,

n See dose, surface-absorbed.

dose, subantimicrobial

n the quantity of medication to be taken at one time for purposes other than the elimination of disease-causing microorganisms.

dose, surface-absorbed,

n the absorbed dose delivered by a radiation beam at the point where the central ray passes through the superficial layer of the phantom or patient.

dose, therapeutic,

n a quantity several times larger than the maintenance dose; used in vitamin therapy in which a marked deficiency exists.

dose, threshold,

n the minimum dose that will produce a detectable degree of any given effect.

dose, tissue,

n the dose absorbed by a tissue or tissues in a region of interest.

dose, tolerance,

n See dose, maximum permissible.

dose, toxic,

n the amount of a drug that causes untoward symptoms in the majority of persons.

dose, transit,

n a measure of the primary radiation transmitted through the patient and measured at a point on the central ray at some point beyond the patient.

dose, U.S.P,

n See dose, median effective (ED50); dose, lethal.

dose, volume,

n See dose, integral.

dose, weekly permissible,

n a dose of ionizing radiation accumulated in 1 week and of such magnitude that, in view of present knowledge, exposure at this weekly rate for an indefinite period of time is not expected to cause appreciable bodily injury during a person's lifetime.

dose

the quantity to be administered at one time, as a specified amount of medication or a given quantity of radiation.

absorbed dose

that amount of energy from ionizing radiations absorbed per unit mass of matter, expressed in Grays.

air dose

the intensity of an x- or gamma-ray beam in air, expressed in coulombs per kilogram.

booster dose

an amount of immunogen (vaccine, toxoid or other antigen preparation), sometimes smaller than the original amount, injected at an appropriate interval after primary immunization to enhance and sustain the immune response to that immunogen.

curative dose (CD)

a dose that is sufficient to restore normal health.

divided dose

a fraction of the total quantity of a drug prescribed to be given at intervals, usually during a 24-hour period.

dose equivalent limits

the limits of ionizing radiation set for radiation workers and the general public by the International Commission on Radiological Protection. For radiology workers this limit for the whole body is 50 mSv.

fatal dose

lethal dose.

dose fractions

in radiation therapy, the small doses given to reach the total radiation dose during the treatment period.

infectious dose 50 (ID50)

that amount of pathogenic microorganisms that will produce infection in 50% of the test subjects.

infective dose (ID)

that amount of pathogenic microorganisms that will cause infection in susceptible subjects.

lethal dose (LD)

the amount of toxin or drug that will kill an animal.

dose level

the amount administered per unit of body weight.

loading dose

the initial large dose of a drug given to bring tissue and fluid levels to an effective concentration quickly. Called also priming dose.

maintenance dose

the smaller doses given to maintain effective levels in body fluids and tissues after the loading dose has achieved the concentration desired.

maximum permissible dose

see dose equivalent limits (above).

median curative dose (CD50)

a dose that abolishes signs in 50% of test animals.

median effective dose (MED)

the dose that produces the desired effect in 50% of the test animals.

median lethal dose (MD50)

the quantity of an agent that will kill 50% of the test subjects; in radiology, the amount of radiation that will kill, within a specified period, 50% of individuals in a large group or population.

minimum lethal dose (MLD)

the lowest dose which kills all of the test subjects.

dose rate

the amount administered per unit of time.

dose response

1. the incremental change in the subject per unit of additional dose. The response as a function of the dose.

2. the frequency of occurrence of a disease as the intake of the suspected risk factor increases. The relationship is expressed by the proximity of the illustrative curve to the expected relationship.

skin dose

1. the air dose of radiation at the skin surface, comprising the primary radiation plus backscatter.

2. the absorbed dose in the skin.

tolerance dose

the largest quantity of an agent that may be administered without harm.

Patient discussion about dose

Q. dose it ever get better? Dose the feeling of useing ever go away?

A. Well to answer you question bluntly, no they never go away. It just gets easier to say no. I still want to use everyday and I have been clean for 4 years. I still have using dreams. The hard days are when you try to tell yourself that all your problems would go away if you could just get high one more time. what one more time gonna hurt?.....Everything....drugs are way to escape or make you feel like someone your not. my biggest hurdle was really looking at myself and then forgiving myself for all the pain my addiction caused. Everyone has their bottom. Everytime you want to use, put yourself back at that bottom. you will come to realize that life has been patiently waiting for you. The darkness will will fade and you will find your place. Good luck to you I hope you find strength will come in time.

Q. how long dose costochondritis last

A. a friend of mine who had the disease saw an improvement within a few weeks, and it resolved completely within a few months,but his doctor said there are patients in whom this problem persists for some time. All symptoms of pain should resolve within six months.

Q. hemorroid stapling dose any one know about this first hand,or had it done themself? mail me if you have!Thanks Hi, I will have this done on 8/4 . I do need to have some info. about it from someone who has had it done what I need to know before hand!HOW MUCH PAIN, BLEEDING ect. Drs can only tell you so much because they do the surgery but not had it done themself. Please let me know soon, Please!

A. I haven't had it done first hand but I do know from people who have done it that it can hurt in the first few days after and there will be slight bleeding, however that is expected decrease dramatically and make the bleeding eventually stop.

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