In Ayurveda, Grahani Dosha is one among the Mahagadas. The organ Grahani is the seat of Jatharagni so both are interrelated. It’s supported and nourished by the strength of Agni. Functionally weak Agni i.e mandagni causes improper digestion of ingested food & leads to Grahani roga present with a symptom of muhurbadda and muhurdrava mala pravrutti. Grahani is a disease of great clinical relevance in modern era because of its direct link with the improper food habits and stressful lifestyle of the present time. Vitiation of Agni affect the digestion process and vitiates proper formation of further dathus thus affecting the nourishment of the body, so for the treatment, concentration should be kept on management of Agni. Thus this article aims to give an essential knowledge about Grahani & explore the utility of Takra prayoga in Grahani roga as Takra being Tridoshahara, Deepana, Grahi, and Lagu helpful in treating in Grahaniroga.