I need to send a mass e-mail out to 2,000 e-mail addresses. What software do you suggest? The price is irrelevant. I just need the best programs. It would be best if you could give me four or five different options.

Most mass emailing software gets picked up by antivirus i find, usually as a "Hacktool" .
I once had to send 250 emails, each with a different text and i used a slightly altered version of the Hee-Haw Mailer (php). All this required was taking the email addresses from a list box on the page and sending them within a For loop.

Are all the emails in a file, on their own line, or seperated by a certain character, like : or * ? Because if they are, I'll post the source code to a PHP mass mailer I wrote that'll read the file, seperate the emails, and then loop a mail() message to all of the email addresses.

I need to send a mass e-mail out to 2,000 e-mail addresses. What software do you suggest? The price is irrelevant. I just need the best programs. It would be best if you could give me four or five different options.

Do a google on a mailer. That isn't your problem. Does your provider allow you to post that much? Mine certainly doesn't!