I am wondering if I can have multiple portfolios on my site? I am using this for an education site. I want each of my curriculum areas to have a sortable portfolio for their specific area to show resources.

science would have a portfolio, but so would math. The items in each of their portfolios would be different.

You start by creating a blank page for each portfolio (using the pages module in the WP admin panel). Then you go to the Avisio Options and click Portfolio Options (in the menu on the left). There you can see a link to add a new portfolio and add as many as pages you created. Set the page dropdown for each and adjust the settings accordingly.