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Center for Insoluble Protein Structures

inSPIN - from structure to biological intervention

In inSPIN, we do structural characterization of biological macromolecules to generate knowledge that can be used systematically to design ways for biological intervention. The ambition is to generate and exploit results from structural and functional analysis to rationally design synthetic antimicrobial peptides, small molecule inhibitors for fibril formation, new contrast agents for early-stage detection of amyloid diseases, and a molecular basis for understanding extracellular matrix degradation, to name some specific targets.