Wow this question can definately not be answered by anyone alone Blackonyx. You have a condition that is so hard to control with just one drug for everyone with fibro. I am thinking you are speaking of the pain issues associated with fibro and want to know the best drug for this issue. I think the best I could do is suggest a few I have tried. Amitriptaline- caused some ups and downs (mentally) didn't help pain issue, helped sleep better. Morphine Sulphate - made me extremely tired and I had reverse reaction to this it caused more muscle pain for some reason. Lyrica ( pregabalin) - I didn't do well on this either it made my heart rate soar and I was in almost a drunken state after second pill but I must say pain was decreased if you don't have an alergic reaction to it. I am now on Fentanyl Patch and started at 25mg and staying at 50mg. I think personally the patch was the best for pain so far because I don't have the ups and downs as it gives a smooth steady flow of medicine over 3 days time. I also take 5mg of Oxycodone for breakthrough pain (without the Tylenol). As long as you don't have issues with addiction I would say these 2 meds combined have saved my life from pain and fatigue. I was on the oxycodone alone for a year and I had so many ups and downs. If you are in alot of pain all the time you need a long acting med too. By the way I am sure most people know you need to tolant to narcotics before being placed on patch it is a very strong med. Well gluck with everything and I hope this answer helps.