In order to screen the cadmium-tolerant soybean resources, the different responses of the wild and the cultivated soybean to cadmium stress were studied.Taking a cultivated soybean Liaodou 24 and a wild soybean (Glycine soja) 1502 as the research materials,plant height,protective enzyme activity (SOD, POD, CAT), malondialdehyde (MDA) content were investigated under treatments with different cadmium concentrations（0,20,40,80 mg·kg-1）and different treatment times（20,30,40 d）.The results showed that with more treatment concentrations and more time, plant height of both the cultivated soybean and the wild soybean seedlings were lower than the control. When the cadmium concentration was 40 and 80 mg·kg -1, treatments were significantly lower than that of the control. The effect of reducing plant height in the cultivated soybean was earlier and more obvious than that in the wild soybean. There was greater difference in SOD, POD, CAT activity and MDA content to the cadmium stress between the wild soybean and the cultivated soybean.The changes of SOD and POD activity were more sensitive than that of CAT. Three enzyme activities of the cultivated soybean were more varied and more obvious inhibition effect at high concentrations compared with the wild soybean. The effect of increasing MDA content in the cultivated soybean was earlier and more obvious than that in the wild soybean. Compared with the cultivated soybean, the wild soybean are more tolerant to heavy metal cadmium, which can be used as an important genetic resource in anti-cadmium breeding of soybeans.