The Xio onboard synth will not respond to MIDI data from my computer when using Hybrid mode.

In the template edit menu there is a 'Synth By MIDI' option. This needs to be set to 'On' for any MIDI information from your computer to be sent to the Xio synth engine when a Hybrid mode template is selected. If this is set to 'Off' the synth can only be controlled using the Xio's keyboard when using hybrid mode.