..Recent anatomical, pathological, and bacteriological studies in SIDS confirm that the multidisciplinary approach provides the best approach to the challenging problems of SIDS and sudden unexplained perinatal death...

Sudden and unexpected infant death due to an hemangioendothelioma located in the medulla oblongata

..Necroscopy studies of sudden infant death should always include an accurate histological examination of the medulla oblongata on serial sections but seldom do...

Hypoplasia and neuronal immaturity of the hypoglossal nucleus in sudden infant death

G OttavianiInstitute of Pathology, Lino Rossi Research Centre for the study and prevention of unexpected perinatal death and SIDS, University of Milan, ItalyJ Clin Pathol 59:497-500. 2006

..Her sudden death offered a unique insight into the possible role of delayed neuronal maturation and hypoplasia of the hypoglossal nucleus in representing a likely morphological substrate of sudden death...

Histopathology of the cardiac conduction system in sudden intrauterine unexplained death

..It remains poorly understood and incompletely examined both morphologically and functionally. The aim of this work is to examine the likely role of cardiac conduction system in relation to sudden and unexplained fetal death...

Fibromuscular hyperplasia of the pulmonary artery in sudden infant and perinatal unexpected death

Giulia OttavianiLino Rossi Research Center for the Study and Prevention of Unexpected Perinatal Death and SIDS, University of Milan, Milan, ItalyCardiovasc Pathol 18:223-30. 2009

..Tumor staging, presence of metastases, local recurrence, chemotherapy regimen, anatomic location, size of the tumor, and percentage of tumor cells destroyed after neoadjuvant chemotherapy have effects on the outcome...

Sudden death due to lymphomatous infiltration of the cardiac conduction system

..Osteosarcoma has also been associated with the use of intravenous radium and Thorotrast. Exposure to alkylating agents may also contribute to its development ,and it is apparently independent of the administration of radiotherapy...

..A number of long-term survivors also achieved high ranking in the professional and commercial work place. These positive aspects should be recognized and emphasized to patients and their parents when discussing the outcome...

Techniques and criteria in pathologic and forensic-medical diagnostics in sudden unexpected infant and perinatal death

Luigi MatturriInstitute of Pathology, Lino Rossi Research Center for the Study and Prevention of Unexpected Perinatal Death and SIDS, University of Milan, Milan, ItalyAm J Clin Pathol 124:259-68. 2005

..The data and arguments presented herein provide a brief survey tending to open, rather than conclude, a far-reaching subject and to motivate medicolegal specialists and pathologists to perform more in-depth study...

Sociooccupational and physical outcomes more than 20 years after the diagnosis of osteosarcoma in children and adolescents: limb salvage versus amputation

Giulia OttavianiDivision of Pediatrics, Children s Cancer Hospital, The University of Texas MD Anderson Cancer Center, Houston, Texas Department of Clinical Sciences and Community Health, University of Milan, Milan, ItalyCancer 119:3727-36. 2013

..In the current study, the authors compared the very long-term survival outcomes of patients with osteosarcoma who were treated with either limb salvage procedures or amputation...

Cytoarchitectural organization of the parabrachial/Kölliker-Fuse complex in man

..Maternal smoking is increasingly being demonstrated to be one of the main contributors to developmental neurological alterations in the offspring...

Early atherosclerotic lesions in infancy: role of parental cigarette smoking

Luigi MatturriInstitute of Pathology, Lino Rossi Research Center for the Study and Prevention of Unexpected Perinatal Death of term fetus stillbirth and neonatal and Sudden Infant Death Syndrome SIDS, University of Milan, Milan, ItalyVirchows Arch 447:74-80. 2005

..We suggest that the oxidants present in the gas phase of the parental cigarette smoke pass through the endothelium and induce at first the c-fos gene activation and subsequently the PCNA positivity, that is, a proliferative process...

Hypoplasia of the parabrachial/kölliker-fuse complex in perinatal death

..In conclusion, we support the role of the EN-2 gene in the normal neuronal development and in the anatomic organization of the human ArcN as well as the possible existence of EN-2 mutations related to hypoplasia of this nucleus...

Preliminary study on the cytoarchitecture of the human parabrachial/Kölliker-fuse complex, with reference to sudden infant death syndrome and sudden intrauterine unexplained death

..Consequently, we can diagnose delayed or altered processes of differentiation during the development of the human cerebellar cortex...

Unexpected perinatal death and sudden infant death syndrome (SIDS): anatomopathologic and legal aspects

Luigi MatturriInstitute of Pathology, Lino Rossi Research Center for the Study and Prevention of Unexpected Perinatal Death and Sudden Infant Death Syndrome SIDS, University of Milan, Milan, ItalyAm J Forensic Med Pathol 26:155-60. 2005

..Many studies have described the development of preatherosclerotic coronary artery lesions in infancy. The observations reported in the literature regarding the fetal origin of coronary artery lesions are rare and controversial...

Expression of apoptosis and proliferating cell nuclear antigen (PCNA) in the cardiac conduction system of crib death (SIDS)

..The AI was higher in the AVN, HB and the initial tract of bundle branches than in the common myocardium (p<0.05; Student's t test)...

Role of somatostatin and apoptosis in breathing control in sudden perinatal and infant unexplained death

A M LavezziLino Rossi Research Center for the Study and Prevention of Unexpected Perinatal Death and Sudden Infant Death Syndrome, Institute of Pathology, University of Milan, ItalyClin Neuropathol 23:304-10. 2004

..To obtain basic information about the expression of somatostatin in the human central nervous system and, in particular, to evaluate its possible involvement in unexplained perinatal and in sudden infant death syndrome...

Sudden Infant Death Syndrome (SIDS): a study of cardiac conduction system

..It was concluded that the combination of some biomarkers (additional chromosomes 11, high PCNA and DNA indices) may allow identification of more aggressive colorectal adenomas with increased ability to undergo malignant transformation...

Sudden infant death triggered by dive reflex

L MatturriLino Rossi Research Centre for the study and prevention of unexpected perinatal death and sudden infant death syndrome SIDS, Institute of Pathology, University of Milan, 20122 ItalyJ Clin Pathol 58:77-80. 2005

..The possible role of parental cigarette smoking in the pathogenesis of arcuate nucleus hypoplasia and early coronary atherosclerotic lesions is also discussed...

..Because the fetal origin of coronary artery lesions is controversial, early atherosclerotic coronary artery lesions in late fetal stillborns and infants, as well as the possible atherogenic role of maternal cigarette smoking, were studied...

..This article affirms the value of the application of the Ilizarov frame for gradual transport of the ipsilateral fibula to replace massive tibial bone loss following chronic refractory osteomyelitis...