The most common sites of infarct were frontal lobe (42%) and parietal lobe (29%).

Children without evidence of stroke (MRI or clinically) performed in the average range of normal on all tests.

Those children with evidence of silent infarct had below average scores (compared to the no-stroke group) on the IQ verbal and performance scales, particularly in the areas of math and numerical conceptualization.

Children with evidence of stroke had significantly lower cognitive scores and achievement scores compared to the no-stroke group.

Author's Conclusions There is a need to further investigate neurocognitive functioning in children SCD. Recognition of their specific needs will allow for the development of comprehensive
treatment plans appropriately suited for each child.

Clinical/Scientific Implications This article highlights the importance of identifying neurocognitive deficits in a population of children that might otherwise be simply classified as underachievers.
With the understanding of these issues parents, educators, and mental health professionals will be better able to serve these patents.

Oncolink's ASH Coverage made possible by an unrestricted Educational Grant from Amgen.