(CNN) - A US Navy plane crashed into the ocean southeast of Okinawa Wednesday afternoon, leaving three people missing in the latest of a string of troubling incidents facing the Navy in waters off East Asia this year.

The C2-A Greyhound transport plane was carrying 11 crew and passengers to an aircraft carrier when it crashed into the Philippine Sea around 2:45 p.m. Japan Standard Time, the Navy said.

Eight people have been rescued and are in good condition aboard the carrier, the USS Ronald Reagan, the Navy said in a statement. US and Japanese ships and planes are searching the area for the three people who remain missing.

The names of those who were onboard are being withheld, pending the notification of their next of kin, the Navy said.

"Our entire focus is on finding all of our sailors," Navy Rear Adm. Marc H. Dalton said. "US and Japanese ships and aircraft are searching the area of the crash, and we will be relentless in our efforts."

The plane was carrying passengers and cargo from Marine Corps Air Station Iwakuni in Japan to the carrier when the plane crashed about 500 nautical miles southeast of Okinawa, Japan.

A Navy public affairs officer told CNN the plane was on approach to the carrier, but didn't know how far away it was from the ship.

The cause of the crash wasn't immediately known, according to an initial statement from the US Navy 7th Fleet. "I have been informed from the US military that engine trouble may have caused (the crash)," Japan's Defense Minister Itsunori Onodera told reporters Wednesday.

Troubled year for Navy in Pacific

It's been a difficult year for the Navy in the western North Pacific following a spate of incidents -- most involving ships assigned to the East Asia-based US 7th fleet -- that included the deaths of 17 sailors.

In August Vice Adm. Joseph Aucoin was relieved of his duty as the commander of 7th Fleet following a deadly collision between the destroyer USS John S. McCain and a merchant ship off Singapore that left 10 US sailors dead.

In June, the guided-missile destroyer USS Fitzgerald, also of the 7th Fleet, collided with a cargo ship off Japan, killing seven US sailors.

Those two fatal collisions were "avoidable" and "numerous failures occurred on the part of leadership," a Navy report concluded earlier this month.

At least two other incidents involving US 7th Fleet ships happened in waters off East Asia this year.

On Saturday, a Japanese tugboat lost propulsion and drifted into the USS Benfold in a bay off central Japan, causing minor damage to the guided-missile destroyer, the Navy said.

In late January, the guided-missile cruiser USS Antietam ran aground in Tokyo Bay, damaging its propellers.

Another incident in East Asian waters involved a US 3rd Fleet ship: In May, the guided-missile cruiser USS Lake Champlain was struck by a South Korean fishing boat off the Korean Peninsula.

The Navy has launched multiple investigations and reviews in the wake of this year's accidents.

The C2-A that crashed Wednesday belongs to a Japan-based squadron that generally flies cargo and passengers between shore bases and the USS Ronald Reagan.

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