Adrenal Gland - Fibrosis - Gallery

Adrenal gland - Fibrosis in a female F344/N rat from a chronic study. A large focal area of mature fibrous connective tissue (F) replaces parts of the normal cortex (C) and medulla (M); there is also focal mineralization (arrow) and a cluster of pigment-laden macrophages (arrowhead).

Adrenal gland, Cortex - Fibrosis in a female Sprague-Dawley rat from a chronic study. Focal fibrosis in the cortex is associated with an organized thrombus (arrow).

Adrenal gland, Cortex - Fibrosis in a female Sprague-Dawley rat from a chronic study (higher magnification of Figure 5). There is residual hemorrhage (arrow) and pigment accumulation (arrowhead) within the focus of fibrosis.

Adrenal gland, Capsule - Fibrosis in a male F344/N rat from a subchronic study. There is focal capsular fibrosis (arrow).

Adrenal gland, Capsule - Fibrosis in a female F344/N rat from a chronic study. The capsule is thickened by fibrosis (F), most likely a sequela to the necrosis (Ne) in the adjacent retroperitoneal fat. C = cortex, M = medulla.