Intel freezes up less and can run 1gb files. The guides still dont show right after placing. This weird yellow tooltip also stays stuck on the screen still and sometimes file operations like save freeze when doing 1gb files @ 4k resolution.

Nvidia just struggles and locks up more on Arch wine staging using the blob. I never expected usability and stability to improve but it has on open Intel drivers.

After that I was able to launch successfully only 32-bit version.
PS works quite good, but drawing tools are still not working properly. And that's sad. Also, after first start PS noticed me that something is wrong with graphics acceleration (I have Intel HD 4400). But other things seems to be working and it is stable.

Currently running Photoshop CS6 under Wine 1.7.34 on Mint.
I too have experienced issues where some tools will not properly draw when holding the mouse down. Sometimes I can draw squiggles, sometimes it's just a dot.

Thankfully I found a workaround to this issue in tool options.
Simply turn off 'Spacing' for each drawing tool (Brush, Eraser, Pencil, etc). After that, dots should be no more.