Synopsis

Between 2012 and 2014, consecutive patients with UC undergoing colonoscopy to assess mucosal healing were also requested to bring two stool samples. The samples were assessed using FIT (with <100 ng/ml as a cut-off) and Fcal (using <250 µg/g as a cut-off), and results were compared against the Mayo endoscopic subscore.

A total of 92 patients with UC completed 105 colonoscopies, FIT, and Fcal measures. The sensitivity of both stool tests for predicting mucosal healing were similar (0.86 vs. 0.86), providing that mucosal healing was defined by a Mayo endoscopic subscore of either 0 or 1. For a Mayo endoscopic subscore of 0, FIT was more sensitive than Fcal (Table 1) although the areas under the receiver operating characteristics (ROC) curve were similar: 0.83 and 0.82 for FIT and Fcal, respectively.

Table 1

Details

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