Life is like a rollercoaster. It has some ups and downs. Sometimes you can take it slow or very fast. It may be hard to breathe at times, but you have to push yourself and keep going.

Your bar is your safety. It’s like your family and friends. You hold on tight and you don’t let go. But sometimes you might throw your hands up, because your friends and family will always be with you. Just like that bar keeping you safe at all times.

4.00am GMT

“We refuse to be ignored by those who will not listen,” says one student.

Antidepressants work – some more effectively than others – in treating depression, according to authors of a groundbreaking study which doctors hope will finally put to rest doubts about the controversial medicine.

Millions more people around the world should be prescribed pills or offered talking therapies, which work equally well for moderate to severe depression, say the doctors, noting that just one in six people receive proper treatment in the rich world – and one in 27 in the developing world.

Dua Lipa and Stormzy, two of Britain’s most exciting breakthrough pop acts, have beaten much more experienced competitors to the top prizes at the ceremony at London’s O2 Arena.

Stormzy, AKA 24-year-old south London grime rapper Michael Omari, beat big names including Sheeran and Liam Gallagher in the best British male category, thanks to the piercing flow and emotive balladry showcased on his debut album Gang Signs and Prayer. That LP also won the most prestigious award of the night, British album of the year, again beating Sheeran as well as Rag’n’Bone Man, J Hus and Lipa.

No 10 forced to deny government is seeking open-ended transition period prior to talks at Chequers

Theresa May has been forced to reassure jittery Brexiters on her own back benches as her 11-strong Brexit inner cabinet prepared to assemble for an eight-hour awayday to thrash out a deal on Britain’s future relationship with the European Union.

After another day in which Conservative differences over Brexit were exposed, ministers were summoned to the PM’s country retreat of Chequers for talks scheduled to go on until 10pm on Thursday.

The higher education strike affecting an estimated 1 million students this week may have been provoked by hardline positions taken by some of the UK’s wealthiest universities, according to academics fighting against pensions cuts.

Oxford and Cambridge universities and several of their colleges have backed policies resulting in the harsh cuts to pensions prompting professors at those institutions to mount efforts to overturn their support.

Immigration detainees disclose to Guardian that staff refused to to let panicking people out

Immigration detainees whose coach caught fire as it took them to a deportation flight were handcuffed by escort staff before they were allowed to get off, in breach of Home Office rules, eight of the detainees have said.

In interviews with the Guardian, the detainees said that just minutes before the vehicle exploded and as fumes filled the cabin, one of the guards started handing out handcuffs to his colleagues.

Sealed single-page document filed in federal court does not shed light on the nature of the new charges

The special counsel investigating possible collusion between the Trump campaign and the Kremlin has stepped up pressure on the former campaign manager Paul Manafort by filing new sealed court charges against him.

Reuters saw a court record referring to the sealed charges, which were also directed against Rick Gates, Manafort’s former business associate, but the documents provided no details on the nature of the charges.

Lanre Haastrup challenges ban in court after hospital staff allege he was aggressive

The father of Isaiah Haastrup, the profoundly brain-damaged baby boy whose life support system is to be turned off, has been banned from visiting him in hospital even though his son may only have days to live.

Labour has stepped up its war of words with rightwing newspapers over claims that Jeremy Corbyn met a Czechoslovakian spy in the 1980s, calling the allegations “completely surreal” and “utterly ridiculous”.

As lawyers for Corbyn threatened the Conservative MP Ben Bradley with legal action over a tweet repeating the claims, Corbyn’s spokesman blamed “significant parts of the national press which are owned by billionaire tax exiles” for “a succession of false and absurd stories”.