Summary of Meeting:Lymphocytes mediate the adaptive immune responses to antigens derived from infectious agents, transformed cells, transplanted organs and, in the setting of autoimmunity, ones own cells. The study of lymphocyte activation and gene expression is central to understanding the complex biology of these cells and offers hope for regulating these cells in different clinical settings. Much has been learned in the past several decades in this field. Receptors, enzymes and adapter molecules have been identified, signaling cascades and networks have been defined, and the complex regulation of gene expression has been explored. Nonetheless many basic questions remain to be elucidated. Among several contentious areas of research that will be presented by experts at this meeting are the actual means by which antigen receptors initiate the activation process, how activation induces changes in signaling pathways, intracellular organelles and the cytoskeleton, and how changes in chromatin and transcriptional factors determine gene expression.

Jürgen Wienands,
Georg August University of Goettingen, Germany
Short Talk: Composition and Dynamic Assembly of B Cell Signalosomes as Revealed by Functional Proteomics

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Gary A. Koretzky,
University of Pennsylvania School of Medicine, USA
Role of SLP-76 in Immune Cell Development and Function

Bridget S. Wilson,
University of New Mexico Health Science Center, USA
High Resolution Imaging of Fc[epislon]RI Organization and Receptor Dynamics: Immobilization is not a Requirement for Signal Initiation

Stephen C. Bunnell,
Tufts University School of Medicine, USA
Short Talk: VLA-4 Inhibits the Centralization of SLP-76 Microclusters by Resisting the Contraction of Myosin IIA Filaments

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