Purpose: The aim of our study was to compare the effects of whole body vibration training exercise, progressive resistive exercise, home-based exercise used in osteoarthritis treatment. Methods: Forty five patients (mean age= 53,2 ± 5,8 years, 43 female, 2 male) diagnosed with knee osteoarthritis (Grade II-III, Kellgren & Lawrence) participated in the study. Participants were divided into three groups, whole body vibration exercise training (Group- 1), progressive resistive exercise training (Group-2) and home-based exercise training (Group-3). The groups performed 36 sessions of exercise training for three days a week for three months. All the groups were included patient education programme at baseline. The dynamic balance of the patients was evaluated by TUG (timed up and go) test. The muscle strength was evaluated by using digital handheld dynamometer (JTech Commander PowerTrack II), pain was assesed according to Visual Analog Scale (VAS), emotional status was evaluated by Beck Depression Inventory (BDI) and Beck Anxiety Inventory (BAI) and quality of life was evaluated by Nottingham Health Profile (NHP). The functional status of the patients was evaluated by Western Ontario and McMaster Universities index (WOMAC) and range of motion (ROM) was assesed with goniometer. The cartilage thickness was measured with ultrasound (US). The assesments were performed at baseline, after third months when they completed the exercise programme and sixth months. Results: Statistically significant improvement was found on quadriceps muscle strength, abductor muscles strength and functional status in all groups (p<0.05). When the groups compared by ANOVA it was found that outcome measures were not significantly different between Group-1, Group-2 and Group-3 (p>0.05). Conclusion: Neither whole body vibration exercise training programme nor progressive resistive exercise and home-based exercise programme were found to be superior for knee OA treatment. All of exercise training programmes have similar beneficial effects in the treatment of knee OA.