By placing a mark on a person in a ritualistic method, this technique will activate as timed even if the person is tortured or put under a trance. This is meant to catch an enemy when their guard is down. Sai mentions that this is used as a last resort technique by the ANBU, and as such, is rare; Sakura likens it to a living time bomb. When Kakashi Hatake requested Tsunade to use it on him, the technique would activate Kakashi's Mangekyō Sharingan technique, the Kamui, upon Hiruko's attempt to assimilate him.