The major phase-variable outer membrane protein of Escherichia coli structurally resembles the immunoglobulin A1 protease class of exported protein and is regulated by a novel mechanism involving Dam and oxyR

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Publications7

Characterization of pic, a secreted protease of Shigella flexneri and enteroaggregative Escherichia coli

I R HendersonCenter for Vaccine Development, Department of Pediatrics, University of Maryland School of Medicine, Baltimore, Maryland 21201, USAInfect Immun 67:5587-96. 1999

..Functional analysis of the Pic protein implicates this factor in mucinase activity, serum resistance, and hemagglutination. Our data suggest that Pic may be a multifunctional protein involved in enteric pathogenesis...

Molecular switches--the ON and OFF of bacterial phase variation

I R HendersonCenter for Vaccine Development, Department of Pediatrics, University of Maryland School of Medicine, 685 West Baltimore Street, Baltimore, MD 21201, USAMol Microbiol 33:919-32. 1999

..Phase variation events are usually random, but may be modulated by environmental conditions. The mechanisms of phase variation events and their significance within the microbial community are discussed here...

Identification of sat, an autotransporter toxin produced by uropathogenic Escherichia coli

D M GuyerDepartment of Microbiology and Immunology, and Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, MD 21201, USAMol Microbiol 38:53-66. 2000

..Based upon its association with pathogenic isolates, its cytopathic phenotype and its ability to elicit a strong antibody response after infection, we postulate that Sat represents a novel virulence determinant of uropathogenic E. coli...

The sigA gene which is borne on the she pathogenicity island of Shigella flexneri 2a encodes an exported cytopathic protease involved in intestinal fluid accumulation

..Sequencing and mapping has identified Ag43 as the likely product of the metastable flu gene first described in 1980 by Diderichsen and responsible for colony form variation in E. coli...

The major phase-variable outer membrane protein of Escherichia coli structurally resembles the immunoglobulin A1 protease class of exported protein and is regulated by a novel mechanism involving Dam and oxyR