- Patients using medications that have a relative risk of prolonging the QT interval or
inducing torsade de pointes if treatment cannot be discontinued or switched to a
different medication prior to starting study drug

- Patients who have received targeted agents within 2 weeks or within 5 half-lives of
the agent and active metabolites (whichever is longer) and who have not recovered
from side effects of those therapies

- Patients who have received chemotherapy or rituximab within 3 weeks or less; or
radiation therapy to > 30% of marrow-bearing bone within 2 weeks or less prior to
starting study treatment; or who have not yet recovered from side effects of such
therapies

- Patients who have received corticosteroids 2 weeks or less prior to registration.
Patients may be receiving chronic corticosteroids if they are being given for
disorders other than than Waldenstrom's Macroglobulinemia

- Patients with active bleeding tendency or receiving any treatment with therapeutic
doses of sodium warfarin or coumadin derivatives. Low doses of Coumadin to maintain
line patency is allowed

- Patients who have undergone major surgery 4 weeks or less prior to starting study
drug or who have not recovered from side effects of such therapy

- Women who are pregnant or breast feeding or women of childbearing potential not using
an effective method of birth control

- Male patients whose sexual partners are women of childbearing potential not using
effective methods of birth control

- Patients with prior malignancy within the last 5 years (except for basal or squamous
cell carcinoma, or in situ cancer of the cervix)

- Patients with known positivity for human immunodeficiency virus (HIV) or hepatitis C;
baseline testing for HIV and hepatitis C is not required

- Patients with a significant history of non-compliance to medical regimens or
unwilling or unable to comply with the instructions given to him/her by the study
staff

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