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Ageing Vulnerability by Novartis Foundation

Book Description

With the ever-increasing rise in life expectancy, there is an urgent need to improve our understanding of the relationship between ageing and the pathogenesis of age-related diseases in order to identify more effective means of prevention, amelioration and management of such diseases. In addition, there is a need to reduce the social and economic impact of the ageing population. Age-related morbidity and mortality vary dramatically among individuals; this book focusses on individual differences in susceptibility to age-related disorders. It contains contributions from leading experts in the field on topics such as: age-related pathology in the brain, age-related processes in stem cells, and age-related effects on the immune system and in bone, muscle and cardiovascular tissue. For all those with an interest in the biology of ageing, this is compulsory reading.

The past decade has seen mounting global concern regarding viral outbreaks such as SARS, avian influenza and West Nile virus. In 2004 and 2005, reports of bird-to-human, and possible human-to-human, transmissions of the H5N1 influenza viruses raised fears that these viruses could cause a pandemic on the scale of the Spanish flu pandemic of 1918.

The heat shock, or cell stress, response was first identified in the polytene chromosomes of Drosophila. This was later related to the appearance of novel proteins within stressed cells, and the key signal stimulating this appearance was identified as the presence of unfolded proteins within the cell.

The recent identification of susceptibility genes for schizophrenia, depression and learning and memory dysfunction suggest that psychiatric disorders may be influenced by a small number of genes with multiple actions.

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