Diffusion
Tensor Tractography of Corpus Callosum Development Across the Lifespan

Throughout life, brain changes occur, including in the
corpus callosum (CC). Previous DTI studies used region-of-interest analysis on
a mid-sagittal slice to study CC development, but it has not been examined with
tractography. We used tractography to segment the CC based on seven distinct
target regions, and examined development in 313 healthy subjects aged 5-59
years. Fractional anisotropy (FA) and mean diffusivity (MD) followed quadratic
trajectories, with FA increasing then decreasing and MD following an opposite
trend; peaks occurred between 26-44 years. A pattern was observed in which
anterior and posterior regions peaked earlier than central areas.