Staphylococcus aureus - Xen29

Staphylococcus aureus - Xen29 bioluminescent pathogenic bacteria for in vivo and in vitro drug discovery. This product was derived from a parental strain from the American Type Culture Collection, used under license. Staph. aureus-Xen29 possesses a stable copy of the Photorhabdus luminescens lux operon on the bacterial chromosome.

Infectious disease is a perennially important area for both life science research and drug discovery. Some of the first applications of IVIS® imaging technology were in tracking infections and monitoring host responses, and these applications are still at the forefront of research.

PerkinElmer's bioluminescent infectious disease light-producing microorganisms have been developed to mimic both acute and chronic standard infection protocols presently used by researchers.

Engineered Bacterium: Staphylococcus aureus - Xen29

Parental Strain: American Type Culture Collection, used under license

In Vitro/Ex Vivo: Growth profiles, Antibiogram, Catheter model

In Vivo: Sepsis, Soft tissue, and Biofilm models

Advantages of using bioluminescent light-producing microorganisms for drug discovery in vitro:

Rapid and readily amenable to high throughput screening, e.g., 96 or 384-well format