The Guthix full helm is a decorated rune full helm that is affiliated with the god Guthix. Like all god affiliated rune items, its bonuses are the same as its rune counterpart, but also offers a +1 Prayer bonus. Visually, the only difference is the colour of the plume which is green for the Guthix full helm and purple for the rune full helm.

The full helm requires 40 Defence to wear and cannot be made using the Smithing skill. Players can obtain a Guthix full helm as a reward from completing a level 3 Treasure Trail.