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Capecitabine improves survival of patients with rare cancer by almost a quarter

News, 18 May 2017

Patients who take capecitabine after surgery for bile duct cancer live for almost a year and a half longer than those not given the drug, according to the results of a Cancer Research UK funded trial presented at the 2017 ASCO Annual Meeting in Chicago.

The BILCAP trial is one of the first to look at testing treatments for bile duct cancer (Cholangiocarcinoma) and gall bladder cancer following surgery. This is because for rare conditions like bile duct cancer it is difficult to recruit enough patients to clinical trials. The researchers are now calling for capecitabine to be given to all patients after surgery.

In the study, around half of the 450 patients were given capecitabine for six months after surgery, and the other half only had surgery.

Three year survival improved by almost a quarter (23%) in patients who were given capecitabine, and the average survival was increased to 53 months from 36 months compared to for those who only had surgery.

Professor John Primrose, lead researcher based at the University of Southampton, said: “While rare, bile duct cancer is difficult to treat and until recently there has been very little progress in treating the disease. Our results clearly show that patients who have surgery should be given capecitabine, as a result of which more will survive and with few side effects.”

Professor Peter Johnson, Cancer Research UK’s chief clinician, said: “Research and trials are helping us tackle all types of cancer more effectively. Rare cancers like this have previously been a difficult problem, but by organising large trials, in many cases with international collaboration, we can find better ways to look after people with these illnesses. Speeding up progress is going to depend on better laboratory science to understand the processes that drive cancer cells and smart trials to use this knowledge to best effect.”