..Thus, some of the anti-inflammatory effects of estrogenic compounds may be mediated and activated by PPARs suppressing a diverse array of inflammatory responses caused by A beta in astrocytes in primary culture...

Oestradiol or genistein rescues neurons from amyloid beta-induced cell death by inhibiting activation of p38

Soraya L VallesDepartment of Physiology, University of Valencia, School of Medicine, Valencia, SpainAging Cell 7:112-8. 2008

..We conclude that the expression of sirtuins is subject to tight redox regulation by the [NADH]/[NAD(+)] ratio, which is a major sensor for metabolite availability conserved from invertebrates to vertebrates...