Scientists demonstrated the susceptibility of a newly developed human airway organoid model for enterovirus 71 (EV71) infection. They showed for the first time in a human physiological model that EV71 replication kinetics are strain-dependent. [Emerg Microbes Infect]
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Investigators present an RNA-seq time-course experiment used to investigate the differential and temporal changes induced in the gene expression of human bronchial epithelial cells by the exposure to ultrafine particles generated from diesel and biomass combustion. [BMC Genomics]
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In the absence of IL-13 treatment, nasal and bronchial cells showed a similar IP-10 response in both air-liquid interface (ALI) and submerged cultures. Under the ALI culture, short term IL-13 treatment had a minimal effect on viral and Mx1 levels in both cell types. [Clin Transl Med]
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Researchers discuss the most recent advances made in yes associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) biology in lung cancer and, more importantly, on the newly discovered mechanisms of YAP and TAZ inhibition in lung cancer as well as their clinical implications. [Cancers]
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Spyryx Biosciences, Inc. will present data from the first cohort of its ongoing Phase II clinical trial, HOPE-1, in a late-breaking oral presentation. [Press release from Spyryx Biosciences, Inc. discussing research to be presented at the 41st European Cystic Fibrosis Conference, Belgrade]
Press Release

Roche announced that the FDA has accepted the company’s supplemental Biologics License Application and granted Priority Review for TECENTRIQ®, in combination with Avastin®, paclitaxel and carboplatin, for the initial treatment of people with metastatic non-squamous non-small cell lung cancer. [F. Hoffmann-La Roche Ltd]
Press Release

Bellerophon Therapeutics, Inc. announced that, following the receipt of minutes from a recent meeting with the FDA, the company has reached agreement with FDA on all key aspects of its planned Phase IIb study of INOpulse® for the treatment of pulmonary hypertension associated with chronic obstructive pulmonary disease. [Bellerophon Therapeutics, Inc.]
Press Release

The FDA, in two complaints filed in federal court, is seeking permanent injunctions to stop two stem cell clinics from marketing stem cell products without FDA approval and for significant deviations from current good manufacturing practice requirements. [U.S. Food and Drug Administration]
Press Release

In early April, several days after Viktor Orbán secured his third consecutive term—and fourth overall—as Hungarian prime minister with a landslide victory for his conservative party, the pro-government paper Figyelő; published a list of more than 200 people it called “mercenaries” of George Soros, the American-Hungarian billionaire philanthropist. The list included investigative journalists and human rights advocates—and 30 academics from the Soros-founded, Budapest-based Central European University. [ScienceInsider]
Editorial

The release of three Americans by North Korea is being welcomed in the United States. Leaders of the Pyongyang University of Science and Technology in North Korea also see the move as good news, and are hoping it might ultimately lead to the end of a travel ban that has prevented its U.S. instructors from teaching classes. [ScienceInsider]
Editorial

Research culture and policies are quick to denounce plagiarism, data fabrication and mismanagement of funds, yet we have too long ignored the mistreatment of people. Science is a social endeavor; ignoring harassment perpetuates a culture in which people who experience or witness hostile behaviors are afraid to speak up, cannot do their best work, or leave science altogether. [Nature News]
Editorial