Imodium Multi-Symptom Relief is the only over-the-counter antidiarrheal brand that combines two powerful medicines to relieve symptoms of diarrhea, gas, cramps, and bloating. Each caplet contains 2 milligrams of loperamide HCl to help relieve diarrhea, and 125 milligrams of simethicone to help relieve gas, cramps, and bloating. Imodium Multi-Symptom Relief works faster than loperamide HCl.