Introduction: Intrusive memories are involuntary retrieval from past events which are usually perceived as unsatisfactory. Studies have showed that negative interpretations from these retrievals and inefficient ways in their management are linked to depression. Training proper skills for coping with these retrievals is one of the main goals of "emotional memory management program". As such, the aims of the current study study were to investigate the efficacy of emotional memory management program on reducing intrusive memories and the resultant related distress; negative interpretations; suppression, rumination, and dissociation reactions to intrusive memories.Methods: A sample of women aging 25 and 35 years were enrolled. Voluntary participants (n=112) completed the BDI-II and RIQ (Response to Intrusions Questionnaire). Twenty eight subjects fulfilled the inclusion criteria while 24 of them cooperated with the researcher and were randomly allocated to a training (experimental) or a control group. All participants completed the questionnaires at pre-post-training.Results: Emotional memory management program left a significant effect on reducing intrusive memories-related distress; negative interpretation about them; and suppression reaction to intrusive memories and this effect was stable at one month following. Emotional memory management program's effect on reducing rumination and dissociation reactions to intrusive memories could not be confirmed.Conclusion: Emotional memory management skills training programs may be considered effective in preventing recurrence of depression.