GM2-Activator protein is essential for the in vivo catabolism of GM2, the Tay-Sachs ganglioside, by $\beta$-hexosaminidase A. Progress in understanding the mechanism of the action of GM2-activator protein has been hampered by difficulty in...

This thesis deals with the potential role of the carbohydrate of human fibrinogen in its hepatic catabolism. First, the primary structure of carbohydrate in human fibrinogen was studied. The structural information was used to investigate the...