Overview

MeSH Major

Allosteric Site

Lymphocyte Function-Associated Antigen-1

Methyl Ethers

abstract

This study suggests that sevoflurane also blocks the activation-dependent conformational changes of LFA-1 to the high-affinity form. The allosteric mode of action exemplified by sevoflurane and isoflurane via LFA-1 might represent one of the underlying mechanisms of anesthetic-mediated immunomodulation.