A Mouse Model for Human Norovirus
The authors found that human norovirus (HuNoV) replication in BALB/c Rag-γc-deficient mice is dependent on the immune-deficient status of the host but not on the presence of human immune cells and provides the first genetically manipulable small-animal model for studying HuNoV infection. [mBio]
Abstract|Press Release

Tolerance Has Its Limits: How the Thymus Copes with Infection
Resolving infection in the thymus is important because chronic persistence of microbes impairs the differentiation of pathogen-specific T cells and diminishes resistance to infection. Understanding how these mechanisms contribute to disease susceptibility, particularly in infants with developing T cell repertoires, requires further investigation. [Trends Immunol]Abstract

Adipose Tissue and Immune Function: A Review of Evidence Relevant to HIV Infection
Relationships between body composition and lymphocyte populations, cellular immune activation, and immune reconstitution in HIV infected individuals on antiretroviral therapy suggest that adipose tissue may also affect cellular immune function. This is further supported by in vitro studies demonstrating the effect of adipocytes and adipokines on lymphocyte proliferation, differentiation, and activation. [J Infect Dis]Abstract

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MBio Diagnostics, Inc. Receives NIH Award for POC HIV Device
MBio Diagnostics, Inc. announced that it has received an award from the National Institute of Allergy and Infectious Diseases, a division of the National Institutes of Health (NIH), to develop a low-cost, point-of-care (POC), HIV antigen/antibody combination diagnostic device. The two-year, $1.4 million award will continue work from a Phase I NIH project in which research and development of a POC antigen/antibody combination diagnostic device met or exceeded technical milestones. [MBio Diagnostics, Inc.]Press Release