Lysine is involved in energy metabolism, growth, calcium utilization, bone health, nitric oxide levels and collagen synthesis. We derive this nutrient from foods such as fish, meat and protein-rich nuts.

Some people, such as vegans, may take these supplements to ensure they obtain enough of this nutrient in their diets. Lysine supplements are also used to support the immune system, for herpes simplex labialis breakouts, Bell’s palsy, osteoporosis, metabolic alkalosis and enhancing athletic performance.

Some research supports the use of Lysine for herpes, although other studies have provided conflicting results. More research is needed to confirm potential benefits for this and other purposes.

The most common medicinal use of Lysine is for herpes labialis, or cold sores. Lysine is purported to reduce the healing time of herpes outbreaks, and to lower the risk of recurrence.

Research is mixed on whether Lysine is an effective treatment for this purpose. The Natural Medicines Database rates it as possibly effective for this use because some research has shown improvements while other research has shown no benefit.

An additional small pilot study used a topical ointment of Lysine with other nutrients and botanicals on cold sores. The cold sore was diminished in three days in 40 percent of study participants and in six days in 87 percent.

This significantly shortened the normal untreated cold sore duration, which can last up to 21 days. However, because the treatment used a combination of lysine with other ingredients, it is not possible to determine whether lysine would have this effect on its own. [2]

According to the University of Maryland Medical Center, some researchers believe Lysine may benefit osteoporosis by supporting bone health, although human studies are needed on this subject. [3]

Conversely, the Natural Medicines Database notes that Lysine may interact with osteoporosis when taken with calcium supplements by affecting the balance of calcium absorption and loss.

Lysine is purported to enhance sports performance by supporting muscle tissue recovery. More research is needed on this potential benefit.

This supplement has also been researched for its effects on the immune system, stress, canker sores and diabetes, although more research is required to support any purported benefits for these uses.

Top Lysine Supplements

Lysine Supplement Dosage

To promote healthy function of the body, the recommended dietary allowance of lysine for adults is 38 mg/kg of bodyweight per day. For pregnant and nursing women, the RDAs are 51 mg /kg and 52 mg/kg a day.

For herpes infections, Drugs.com notes that Lysine supplements could be taken in doses from 500 mg to 3 g each day as a preventive measure. Higher doses are used for herpes breakouts. [4]

UMMC recommends having a doctor determine your dosage as it could vary depending on the intended use and other factors.

Children need lysine in their diets to support a healthy body. For children, the recommended dietary allowance from the USDA is as follows:

89 mg a day for those 7 to 12-months’ old

58 mg a day for those 1 to 3-years’ old

40 to 46 mg a day for those 4 to 18-years’ old

Lysine supplement for kids are available at lower doses that the amounts typically given to adults. Doses for pediatric applications should be determined by a doctor.

According to the Institute of Medicine of the U.S. National Academy of Sciences, more research is needed to determine a tolerable upper intake level (UL) for lysine in healthy adults and children.

Are Lysine Supplements Safe?

The Natural Medicines Database rates oral Lysine supplementation as possibly safe for a period of up to one year. NMD notes that side effects are possible with higher doses, including gastrointestinal discomfort.

Lysine is generally well-tolerated as a dietary supplement, but could cause abdominal cramping, stomach upset, gallstones and other adverse reactions, especially at high doses.

This supplement may interact with certain drugs, supplements and health conditions. Consult with a doctor before taking lysine pills of you are using 5-HT4 agonist drugs or calcium supplements.

Lysine is contraindicated for individuals with kidney disease, osteoporosis, and lysinuric protein intolerance. It may interfere with cancer imaging lab tests. Discontinue use before undergoing diagnostic cancer imaging.

Drugs.com notes that Lysine seems to be safe for pre-pubertal children when taken in doses of 1 to 3 g a day. The UMMC recommends the dosage be customized to each child’s weight.

There is insufficient evidence to determine how this supplement could affect pregnant and lactating women. Out of an abundance of caution, its use should be avoided in these populations.

Some individuals use lysine to support their immune system, promote muscle growth and boost athletic performance. It may also support healthy bones and calcium utilization, but more research is needed to understand its effects.

Those considering Lysine supplementation should talk to a doctor in to determine whether this supplement is appropriate for their needs.

OVERVIEW: L-Lysine is an essential amino acid, which means it cannot be synthesized by the body and must be supplemented through the diet. Dietary sources include meat, fish, dairy, eggs, some plants, legumes and soy products. READ MORE...

MECHANISM: As an amino acid, Lysine is a primary building block for proteins. It is also a precursor for hundreds of other compounds forund in the body. Shown to improve calcium absorption and renal conversation of calcium, decrease blood glucose levels, increase plasma cyclic GMP and plasma electrolytes and more diverse actiobs.

DOSAGE: 1 - 3g per day.

SIDE EFFECTS: Rated Possibly Safe for oral use at appropriate dosages. Generally well tolerated, but may cause stomach upset. At high doses, it may cause abdominal cramping, elevated cholesterol levels, gallstones, changes in renal function, and inhibition of platelet aggregation.

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