The present study was designed to examine the chronic (5 day) and acute (2 hr) hemodynamic effects of atrial natriuretic factor (ANF) in conscious normotensive rats. Exogenous ANF was infused to mimic the plasma levels which are found under...

Peripheral and central atrial natriuretic factor (ANF) concentrations were measured across the estrous cycles of rats. Sprague-Dawley female rats, approximately 180 days of age, were maintained under a controlled illumination cycle (L/D: 14/10,...

Atrial natriuretic peptide (ANP) is a vasoactive peptide hormone generated in the atrium of the heart and released in the circulation. ANP exhibits important functions in blood pressure and volume homeostasis, cardiac hypertrophy, and inhibition of...

Atrial and brain natriuretic peptides (ANP and BNP) intiate their signaling by binding to guanylyl cyclase-A/natriuretic peptide receptor-A (GC-A/NPR-A) which results in production of second messenger cGMP. This signaling pathway plays a critical...