Cinnamic acid hydrogen bonds to isoniazid and N'-(propan-2-yl­idene)isonicotinohydrazide, an in situ reaction product of isoniazid and acetone

Abstract: A new polymorph of the cinnamic acid-isoniazid cocrystal has been prepared by slow evaporation, namely cinnamic acid-pyridine-4-carbohydrazide (1/1), C9H8O2·C6H7N3O. The crys­tal structure is characterized by a hydrogen-bonded tetra­meric arrangement of two mol­ecules of isoniazid and two of cinnamic acid. Possible modification of the hydrogen bonding was investigated by changing the hydrazide group of isoniazid via an in situ reaction with acetone and cocrystallization with cinnamic acid. In the structure of cinnamic acid-N'-(propan-2-yl­idene)isonicotinohydrazide (1/1), C9H8O2·C9H11N3O, car­box­ylic acid-pyridine O-HN and hydrazide-hydrazide N-HO hydrogen bonds are formed.

To open or display or play some files, you may need to set your browser up to use the appropriate software. See the full list of file types for an explanation of the different file types and their related mime types and, where available links to sites from where the appropriate software may be obtained.

The download button will force most browsers to prompt for a file name to store the data on your hard disk.