Blopress General Information

Blopress, a specific angiotensin II antagonist, is used alone or with other antihypertensive agents to treat hypertension. Blopress competes with angiotensin II for binding at the AT1 receptor subtype. As angiotensin II is a vasoconstrictor which also stimulates the synthesis and release of aldosterone, blockage of its effects results in a decreases in systemic vascular resistance.

Blopress - Pharmacology:

Blopress competes with angiotensin II for binding at the AT1 receptor subtype. As angiotensin II is a vasoconstrictor which also stimulates the synthesis and release of aldosterone, blockage of its effects results in a decreases in systemic vascular resistance.

Blopress Interactions

No significant drug interactions have been reported in studies of candesartan cilexetil given with other drugs
such as glyburide, nifedipine, digoxin, warfarin, hydrochlorothiazide, and oral contraceptives in healthy volunteers,
or given with enalapril to patients with heart failure (NYHA class II and III). Because candesartan is not
significantly metabolized by the cytochrome P450 system and at therapeutic concentrations has no effects on P450
enzymes, interactions with drugs that inhibit or are metabolized by those enzymes would not be expected.

Lithiumó Reversible increases in serum lithium concentrations and toxicity have been reported during
concomitant administration of lithium with ACE inhibitors, and with some angiotensin II receptor antagonists. An
increase in serum lithium concentration has been reported during concomitant administration of lithium with ATACAND,
so careful monitoring of serum lithium levels is recommended during concomitant use.

Blopress Contraindications

ATACAND is contraindicated in patients who are hypersensitive to any component of this product.