p53 IHC Antibody

Ready To Use

Catalog
Number

Size

Price

Availability

IW-MA1078

9 ml

$258

Yes

Description

The p53 tumor antigen is found in increased amounts in a
wide variety of transformed cells. The protein is also
detectable in many actively proliferating, nontransformed
cells, but it is undetectable or present at low levels in
resting cells. This protein induces cell cycle arrest or
apoptosis in response to sublethal or severe DNA damage,
respectively, by differential transcription of target genes
and through transcription-independent apoptotic functions.
The p53 protein contains 393 amino acids.
Human p53 tumour
antigen is Locatedto band 17p13. p53 mutations are common in
pancreatic cancer and are absent in chronic pancreatitis.

Catalog Number

IW-MA1078

Quantity

9 ml

Host

Mouse

Clone

IMD-53

Isotype

Mouse IgG2a

Immunogen

Recombinant human wild-type p53 protein.

Purity

Purified by the
goat anti-mouse IgG affinity chromatography.

Conjugate

Unconjugated

Species
Reactivity

Human.
Not tested in other species.

Positive
Control

Human skin, tumor.

Cellular
Localization

Nuclear

Form

Ready to use
solution. No further dilution needed. Serum blocking step
should be omitted.