Susan Winandy, Ph.D.

Pathology

Dr. Winandy’s laboratory studies the inflammatory response generated by T cells. Specifically, her expertise lies in the study of Ikaros function in T cell biology. They are one of a few laboratories that focus almost exclusively on Ikaros, a transcription factor involved in gene activation and repression. This work is centered on the role of Ikaros in lymphocyte development and function, including two recent reports illuminating the role of Ikaros in regulating cytokine gene expression in T helper cells. They are particularly interested in understanding how Ikaros regulates programs of gene expression that result in inflammation, and are currently undertaking studies focusing on Ikaros in development of Th1 and Th17 cells.