7463 – Advanced manufacturing process for high throughput, large scale
nanomedicine production
Background:
A
number of therapeutic and diagnostic nanoparticles (NP), or nanomedicines, have
been developed for targeted delivery of drugs and imaging agents for the
treatment of major diseases. However, only a small number of these NPs have
been approved by the FDA due to low reproducibility of... Read More

6376 – Core-shell nanostructures with platinum (Pt) overlayers
on a nano-substrate core, formed of palladium (Pd) for core-shell
nanostructures for use in electro catalytic applications.
Background: Depositing an
ultrathin Pt shell on sustainable nano-substrates is an ideal strategy for
improving the catalytic performance while reducing the content of Pt in a
catalyst. Challenges and... Read More

7430 – A microparticle
delivery system has been developed that allows for more effective sustained
delivery of molecules and proteins on a small scale.
Background: Loading small molecules and proteins
for injection happens on a minute scale and is essential for progress in many
medicinal fields. However, the science thus far has been restricted by the size
and charge of the molecules, as well... Read More

4434 – Carbon nanotubes allow for significant electrode performance in biological applications, and can serve as nanosyringes for drug eution all while preventing major scarring and delivering therapeutic agents. Background: Microelectrode arrays (MEAs) are neural interfaces that connect neurons to electronic circuitry and include implantable interfaces such as deep brain stimulators, cochlear... Read More

5430 – Background: Craniosynostosis is the premature fusion of the cranial suture early in development. If left untreated, blindness, deafness, and delays in development can occur. The current treatment for craniosynostosis uses surgery to remove the fused area and remodel the skull. In up to 40% of patients, the skull re-fuses; necessitating additional surgery that often results in death or... Read More

3702-3712-3713-3716-3817-4222-4892 –
Background: This technology
was developed to enable nano-scale devices that may be self-powered by
mechanical energy rather than an external power source. Many micro-scale and
nano-scale machines have been proposed for use in medical devices and
environmental applications where external power sources are impractical or have
insufficient life. Therefore, there is a need for electrical... Read More

3424 – Background: Cellular imaging techniques are used to provide anatomic detail on the cellular level and are vital for diagnostic applications and research. Current methods include optical probes that use markers attached to antibodies to give information on the presence of specific molecules. Quantum dots are frequently used, but the semiconductor material is potentially toxic to humans, which... Read More

5979 – Background: Protein
drugs and enzyme therapeutics are becoming a critical research focus in
healthcare. Enzyme therapeutics offer advantages over traditional small
molecule drugs, such as higher affinity and specificity and the catalytic
activity to rapidly convert and amplify target molecules into products.
However, the delivery of protein drugs have challenges not seen by traditional
small... Read More

4340 – Background: Mass spectroscopy is a technique that is used to understand the chemical composition
of a sample or compound by analyzing its mass to charge ratio. A sample must be
ionized into charged particles and then passed into a mass spectrometer to
analyze. Most mass spectrometry devices use electron, ion, and laser beam ion
sources, however these approaches can only operate under high... Read More

5132 – Technology: A method for the production of diverse nanostructures on the surface of devices comprised by an element (such as titanium), a metallic alloy (such as Ti6Al4V), or a ceramic (such as TiO2). The method involves subjecting the device to a controlled oxidative environment at high temperatures and for specific time periods, so as to partially or completely cover the surface with... Read More

4660 – Technology: This technology is a delivery system for growth factors
to the human body that improves growth factor retention and allows for tissue
regeneration within an enclosed space. The technology has been used for the
repair of a small animal bone segmental defect. While much bone regeneration
research is focused on the use of three-dimensional scaffolds that support
loading in vivo,... Read More

4293 – This disclosure reports a simple one-step technique for producing arrays and patterns of polymer nanowires on entire wafers. Nanowire size is easily controlled by limiting or extending processing time, on the order of only 5-30 minutes. The technique appears to be applicable to almost any polymer type, allowing tremendous versatility and providing researchers new tools for numerous novel... Read More

4222 – One out of ten people suffers from hearing loss worldwide, constructively and sensorineurally. People are affected by this in a way from mild impairment to profound deafness, both for children and adults. Nowadays, hearing aid devices offer people with hearing loss a significant way to improve the quality of their life. Typically, there are two categories of hearing loss, conductive hearing... Read More

4109 – A semiconducting device includes a substrate, a piezoelectric wire, a structure, a first electrode and a second electrode. The piezoelectric wire has a first end and an opposite second end and is disposed on the substrate. The structure causes the piezoelectric wire to bend in a predetermined manner between the first end and the second end so that the piezoelectric wire enters a first... Read More