Fur transcription factor is activated by iron stress (low iron or iron deficiency), and negatively regulates expression of siderophore biosynthesis and ferri-siderophore uptake genes [PUB_0418, PUB_0419, PUB_0438]. Güell et al reported that Fur controls the expression of several genes in M. pneumoniae [PUB_0418]. We estimated the regulatory effect of Fur on the reported genes using the ratio of gene expression under fur overexpression to that of the average of the control conditions (GC_10-NaCl1.1, GC_10-NaCl1.2, and GC_10-NaCl1.3) [PUB_0418]. Binding site computed by aligning upstream regions (100bp) using MEME. Guell et al used the same procedure for M. pneumoniae, but identified a different motif [PUB_0418].
Binding site has motif GT[TC]TTA[TAC]TTT[TGC]AA[AGT]AA.
Site responds to the condition: fur overexpression.