Drive shafts have been used on motorcycles almost as long as there have been motorcycles. As an alternative to chain and belt drives, drive shafts offer relatively maintenance-free operation and long life. A disadvantage of shaft drive on a motorcycle is that gearing or a Hobson's joint or similar is needed to turn the power 90° from the shaft to the rear wheel, losing some power in the process. On the other hand, it is easier to protect the shaft linkages and drive gears from dust, sand and mud.

The best known motorcycle manufacturer to use shaft drive for a long time—since 1923—is BMW. Among contemporary manufacturers, Moto Guzzi is also well-known for its shaft drive motorcycles. The British company, Triumph and all four Japanese brands, Honda, Suzuki, Kawasaki and Yamaha, have produced shaft drive motorcycles. All geared models of the Vespa scooter produced to date have been shaft-driven. The automatic models, however, use a belt.

Motorcycles with shaft drive are subject to shaft effect where the chassis climbs when power is applied. This is counteracted with systems such as BMW's Paralever, Moto Guzzi's CARC and Kawasaki's Tetra Lever.