Although midazolam use with ketamine is commonly used now a days. However, other studies denied the role of midazolam in reduction of emergence phenomenon when added to for Ketamine sedation .

Other than intramuscular or intravenous routes, ketamine can also be administered through rectal approach for premedication, although the required dose is higher (10 mg/kg). It is also tried through oral or intranasal route for sedation and premedication.