Description

NCBI recently announced a new release of
functional regulatory elements.
NCBI is now providing
RefSeq and
Gene
records for non-genic functional elements that have been described in the literature and are
experimentally validated. Elements in scope include experimentally-verified gene regulatory
regions (e.g., enhancers, silencers, locus control regions), known structural elements
(e.g., insulators, DNase I hypersensitive sites, matrix/scaffold-associated regions),
well-characterized DNA replication origins, and clinically-significant sites of DNA recombination
and genomic instability. Priority is given to genomic regions that are implicated in human disease
or are otherwise of significant interest to the research community. Currently, the scope of this
project is restricted to human and mouse. The current scope does not include functional elements
predicted from large-scale epigenomic mapping studies, nor elements based on disease-associated
variation.

Display Conventions and Configuration

Functional elements are colored by Sequence Ontology (SO) term
using the same scheme as NCBI's Genome Data Viewer:

Methods

NCBI manually curated features in accordance with International Nucleotide
Sequence Database Collaboration (INSDC) standards. Features that are supported by direct
experimental evidence include at least one experiment qualifier with an evidence code (ECO ID)
from the Evidence and Conclusion Ontology, and at least one citation from PubMed. Currently
971 distinct PubMed citations are included in this track.