Kennedy's speech, however, wasn't about football. It was about the space race and the American goal of being the first to land on the moon.

"But why, some say, the moon? Why choose this as our goal? And they may well ask why climb the highest mountain? Why, 35 years ago, fly the Atlantic?" President Kennedy said. "Why does Rice play Texas?"

According to ESPN, the Rice-Texas comment was ad-libbed by President Kennedy. What the president didn't realize was that this small comment in his 18-minute speech would spark a long-time rivalry between the two football programs.

When President Kennedy made his comment, Rice and Texas were both members of the Southwest Conference. Rice actually had a record of 18-17-1 over Texas from 1930 to 1966, according to ESPN.

Ever since a tie in the weeks following President Kennedy's speech, the Owls have been the underdog in the rivalry. The Longhorns went 30-1 against the Owls in the years following, and the Longhorns lead the all-time series 72-21-1.

According to ESPN, the athletic directors from both Rice and Texas intend to keep the Southwest Conference rivalry alive.