Constant buffers have to be aligned to 128 bit boundaries, so that may be the issue. Just for kicks, when you declare your test variable, declare it as a int4 and add the additional three integers to your structure that you are using on the CPU side. That may help you out...

Also can you be more specific about what the error is that you are getting? Is the rendered output incorrect, or do you get compilation errors, or something else?

I make the updateconstantbuffer call every frame.The result is that the variable dont have any value, the rendering is correct and everything else works.

I have align_16 attribute to my constantbuffer struct so it automatic align my bytes.

Have you checked in PIX to see if the constant buffer value is correct? If you look in PIX, and the value is incorrect, then it must be either that you aren't copying enough memory into the constant buffer, or you have an alignment issue (assuming that the buffers are being bound correctly - but you already mentioned that they are).

I would still recommend trying out the manual padding as outlined above, just to try it out. It won't take long to try, and it would clarify if the issue is alignment or not.