Step 2: Find RWE options

Find different options for using real-world evidence (RWE) based on the issues (or ‘effectiveness challenge’) you have identified in step 1. Often these issues arise when generating ‘early’ evidence of relative effectiveness for a medicine.

Selectthe stage of development for your medicine (Early, Mid or Late) then

Choose a category of problem (study Population, defining the Intervention or its Comparator, choosing an Outcome measure, or selecting a Study design).

You will now see a list of possible issues (left column) and corresponding RWE options (right column). For each issue you can see which type of decision-making perspective (pharmaceutical research and development, regulators, health technology assessment) is likely to find this issue relevant at this stage of medicine development.

Click ‘Read more’ to find out about each issue.

Select a RWE option for more information and links to resources (including GetReal resources).

Modelling of final outcomes from trial efficacy is not robust

Funding

The research leading to these results has received support from the Innovative Medicines Initiative Joint Undertaking under grant agreement no [115546], resources of which are composed of financial contribution from the European Union's Seventh Framework Programme (FP7/2007-2013) and EFPIA companies in kind contribution.