My 6 year old has had hives from zithromax, amoxicillin and full body welts from ceftin.

I'm VERY concerned here because my sister (who is a pharmacist) has told me there is 1 left (that is not related to these 3) which I cannot remember the name of right now- which he's had in the past 3 times.

He is on day 7 of the amoxicillin now and has about 50 hives. He has taken the amoxicillin before (maybe 2 times) without issue.

Anyone have any advice or knowledge or experience?

This is not my food allergic child, but def my next step is allergy testing. I need to know for sure.

Biaxin (clarithromycin) is in the same family as Zithromax (azithromycin), they're related to erythromycin. We have patients sensitive to one of them, but not the other. Ceclor is a cephalosporin, as are cephalexin (Keflex), Ceftin, and Suprax. Again, some patients are sensitive to one and not the others. We used to think there was a potential cross-reactivity with cephalosporins and penicillins (Amoxil, Cloxacillin, Clavulin etc) but I recently read a review that says the cross-reaction hasn't borne out. Amoxil is the most likely of all the penicillins to cause a hive-like rash, but some people can still tolerate other penicillins. When someone is allergic, we try to avoid the whole family, but once multiple allergies develop we sometimes need to try individual ones.

Clindamycin (Dalacin) is an alternative to all of the above that is usually safe for people with multiple allergies, as it in a separate family.

Also, I was also thinking about Tetracycline when he become older. I remember my father only taking that one whenever he needed an antibiotic. I'm not sure exactly why, (I know he was allergic to Penicillin <so is my mother> but I do not know if he was actually allergic (hives) or sensitive (gastro or whatever else), I'd ask him but he's no longer living).

I'm thinking he was allergic to multiple, but I have zero confirmation on that.

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