It is well established by a large number of randomized controlled trials that lowering blood pressure (BP) and low-density lipoprotein cholesterol (LDL-C) by drugs are powerful means to reduce stroke incidence, but the optimal BP and LDL-C levels to be achieved are largely uncertain. Concerning BP targets, two hypotheses are being confronted: first, the lower the BP, the better the treatment outcome, and second, the hypothesis that too low BP values are accompanied by a lower benefit and even higher risk. It is also unknown whether BP lowering and LDL-C lowering have additive beneficial effects for the primary and secondary prevention of stroke, and whether these treatments can prevent cognitive decline after stroke.

@article{5b051e28-2720-40b0-a4ae-39932e49c84c,
abstract = {It is well established by a large number of randomized controlled trials that lowering blood pressure (BP) and low-density lipoprotein cholesterol (LDL-C) by drugs are powerful means to reduce stroke incidence, but the optimal BP and LDL-C levels to be achieved are largely uncertain. Concerning BP targets, two hypotheses are being confronted: first, the lower the BP, the better the treatment outcome, and second, the hypothesis that too low BP values are accompanied by a lower benefit and even higher risk. It is also unknown whether BP lowering and LDL-C lowering have additive beneficial effects for the primary and secondary prevention of stroke, and whether these treatments can prevent cognitive decline after stroke.},
author = {Zanchetti, Alberto and Liu, Lisheng and Mancia, Giuseppe and Parati, Gianfranco and Grassi, Guido and Stramba-Badiale, Marco and Silani, Vincenzo and Bilo, Grzegorz and Corrao, Giovanni and Zambon, Antonella and Scotti, Lorenza and Zhang, Xinhua and Wang, HayYan and Zhang, Yuqing and Zhang, Xuezhong and Guan, Ting Rui and Berge, Eivind and Redon, Josep and Narkiewicz, Krzysztof and Dominiczak, Anna and Nilsson, Peter and Viigimaa, Margus and Laurent, Stéphane and Agabiti-Rosei, Enrico and Wu, Zhaosu and Zhu, Dingliang and Rodicio, José Luis and Ruilope, Luis Miguel and Martell-Claros, Nieves and Pinto, Fernando and Schmieder, Roland E and Burnier, Michel and Banach, Maciej and Cifkova, Renata and Farsang, Csaba and Konradi, Alexandra and Lazareva, Irina and Sirenko, Yuriy and Dorobantu, Maria and Postadzhiyan, Arman and Accetto, Rok and Jelakovic, Bojan and Lovic, Dragan and Manolis, Athanasios J and Stylianou, Philippos and Erdine, Serap and Dicker, Dror and Wei, Gangzhi and Xu, Chengbin and Xie, Hengge and Coca, Antonio and O'Brien, John and Ford, Gary},
issn = {1473-5598},
language = {eng},
number = {9},
pages = {1741--1750},
publisher = {Lippincott Williams & Wilkins},
series = {Journal of Hypertension},
title = {Blood pressure and low-density lipoprotein-cholesterol lowering for prevention of strokes and cognitive decline: a review of available trial evidence.},
url = {http://dx.doi.org/10.1097/HJH.0000000000000253},
volume = {32},
year = {2014},
}