Iron and 2-oxoglutarate dependent oxygenases catalyse a range of oxidative reactions. Their catalytic flexibility is proposed to be related to their nonhaem iron binding site which employs two or three protein ligands. A possible penalty for this flexibility is that they may be more prone to oxidative damage. Here we review the evidence for auto-catalysed oxidative modifications to 2-oxoglutarate-dependent oxygenases.

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