Balantidium Coli

Balantidium coli is the largest protozoan parasite in humans and causes a disease called balantidiasis.
It belongs to the ciliophora phylum and is the only protozoan ciliate to infect humans. It goes through two
development phases; a cyst and a trophozoite. Trophozoites are 0.03–0.15 mm long and 0.025–0.12 mm
wide. Their shape is either spherical or oblong. Their surface is covered with cilia and are able to move around.
Trophozoites have both a micronucleus and a macronucleus, which both are normally visible. The macronucleus is
bigger and sausage-shaped whereas the micronucleus is less notable. Cysts are spherical and
0.04–0.06 mm in diameter. They have a tough multilayered shell which protects them against stomach acid of the
host, when ingested. They are usually destroyed at a pH lower than five (normal pH of a healthy stomach is about
three). Some people are weakened by other diseases and thus the cysts are not killed. Unlike trophozoites, cysts
cannot reproduce and do not have any cilia for moving.

The life cycle of Balantidium coli begins, when a human eats food or water that has
been contaminated with infective cysts. If the cysts survive through the stomach, trophozoites are formed in the
small intestine. Trophozoites live in the cecum and the colon of the large intestine. They live and feed in the
lumen but sometimes penetrate the mucosa. They multiply by transverse binary fission in the intestinal wall. Some
trophozoites return to the lumen and encyst (transform into cysts) once the feces dry up. The cysts are formed
either in the large intestine or outside of the body. If the feces get in contact with vegetables or drinking
water, humans might ingest the cysts.

About 1 % of the world's population is infected with balantidiasis. Most infections occur in developing
countries where feces are more likely to get in contact with food and drinking water. In addition to humans, pigs
and other animals carry the disease. People who raise pigs have bigger risk of getting infected with
balantidiasis.

Balantidiasis is often asymptomatic. But in some cases the patient might have
diarrhea, weight loss and dysentery. Dysentery is an
inflammatory disorder of the intestine, particularly of the colon, that causes severe diarrhea containing blood
and/or mucus in the feces with stomach pain and fever. Untreated dysentery cases
can be fatal.

Diagnosis can be made by finding trophozoites from a
stool or tissue sample (collected during endoscopy). Cysts are rarely found. Trophozoites are passed
irregularly and quickly destroyed outside the colon. For this reason many stool samples are usually required
to confirm the disease.

Balantidiasis is treated with tetracycline according to the instructions of your health care
provider. Tetracycline is not recommended for pregnant women or children under 8 years old. If the drug is not
available, then iodoquinol and metronidazole can be used.

Balantidiasis infections can be prevented by following proper hygiene practices. Do not use
human feces as fertilizer in agriculture. Wash your hands after going to the toilet and before meal. Only drink
pure water. Wash vegetables and cook meat properly. Infective Balantidium coli cysts are killed by
heat.