Similar to the Beer Mile, the Four Loko 400 is a drinking/running event. To participate in the Four Loko 400, One must chug an entire can of Four Loko at the starting line and then run a 400 meter dash (1 lap around a standard outdoor track). Where as the beer mile requires at least some endurance and training (in both drinking and running), the Four Loko 400 requires a willingness to not feel your legs and to ignore your sense of reason.

Prefontaine would have owned the Four Loko 400 if he hadn't DUI'ed himself to death.