‘TUMOR SUPPRESSOR PROTEIN’ OR ‘CANCER GENE’?? NEW INSIGHTS INTO BRCA1!!

‘TUMOR SUPPRESSOR PROTEIN’ OR ‘CANCER GENE’?? NEW INSIGHTS INTO BRCA1!!

Experts around the globe estimate that nearly half of all cancer cases are preventable with diet and healthy lifestyle changes!!

With this knowledge in mind and the fact that 90-95% percent of women who develop breast cancer ‘do not have a BRCA inherited genemutation’, this said, what further information should be presented to women who are found to have this genetic BRCA1 coded gene??

By definition, the full name of the BRCA1 gene is “breast cancer 1, early onset” and it codes for a ‘tumor suppressorprotein’. Tumor suppressor proteins help repair DNA that has become damaged in order to ensure stability of genetic material in cells.

Until now, surgery to remove the breasts and ovaries has been the only option presented to patients, however, Kienan Savage, from Queen’s University, Belfast who led the four-year research, said their discovery was “very significant,” adding “it’s the first really credible evidence that ‘oestrogen’ is driving cancer in women with a BRCA1 gene mutation.” The scientists also found that the cells of ‘women with the BRCA1 mutation cannot effectively fight the very high levels of oestrogen’ that exist in all women’s breasts and ovaries, leaving them vulnerable to DNA damage.

According to Dr. C.E, Grant, practicing physician at National Integrated Health Associates in Washington DC, he strongly believes it isn’t just the BRCA gene that puts women at risk of breast cancer; it is the combination of many risk factors ‘with ‘estrone conversion’ being one of the most important’. Estriol, an estrogen that has virtually been ignored by the mainstream medical community, is one of the three principal estrogens produced by the body. Estriol was originally thought to have little significance due to its weak estrogenic activity when compared with estrone and estradiol.

Thus, estradiol is the most important estrogen in non-pregnant females who are between the menarche and menopause stages of life. However, during pregnancy this role shifts to estriol, and in postmenopausal women estrone becomes the primary form of estrogen in the body. This highlights the need for more thorough hormonal testing and further research to better understand the finite connection this hormone has with BRCA1 gene mutations and repairing DNA breaks.