Unsafe abortion is one of the major causes of maternal morbidity and mortality in the developing world. Most unsafe abortions occur where abortion is legally restricted. Like many Latin American countries, Argentina prohibits ...

OBJECTIVE: Little is known about health-related quality of life (HRQOL) of patients with morphea (localized scleroderma). We determined the impact of morphea on HRQOL and clinical and demographic correlates of HRQOL. ...

Lower vertebrates like urodele amphibians and teleost fish retain a robust cardiac regenerative capacity throughout their life, a phenomenon that is mediated through the proliferation of pre-existing cardiomyocytes. The ...

The involvement of hedgehog (Hh) signaling in cell determination and differentiation in a wide variety of tissues in both invertebrates and vertebrate has been well established. However, relative little is known about its ...

Direct oxygen sensors are proteins that serve as "on-off switches" to cause reversible and adaptive changes in the activities of other proteins or genes, with great specificity in response to fluctuations in oxygen ...

Hepatitis C virus (HCV) infection is a major cause of liver disease and a global health problem with inadequate treatment options. An improved understanding of how HCV exploits and subverts host factors to establish infection ...

Virus infection triggers an innate immune response characterized by host cell production of interferon (IFN). Intermediates of viral replication, including dsRNA, initiate a signaling cascade that is amplified within the ...

The capacity of mammalian organisms to cope with hypoxic or ischemic stress is in part mediated by stress-induced transcription factors. Hypoxia-induced mediators include transcription factors, such as the α (alpha) subunit ...

Rhabdomyosarcoma (RMS) accounts for nearly 50 percent of the soft tissue sarcomas that affect children. There are two major histological variants, alveolar (ARMS) and embryonal (ERMS). Both are defined as sarcomas that ...

"Histology of the Female Reproductive System: An Interactive Learning Module" is an interactive animated video project designed to address the need for a complete educational exploration of female reproductive histology ...

Cells respond to stimuli in part through the modulation of gene expression. Signal transduction from the environment to the nucleus culminates in the activation of factors that modify chromatin structure to either facilitate ...

Specialized microenvironments called niches keep stem cells in an undifferentiated and self-renewing state by producing a variety of factors. The size and signaling output of niches must be finely tuned to ensure proper ...

Alternative splicing is emerging as a common mechanism for altering protein expression in response to extracellular cues. Of particular interest is how cell-signaling pathways modify mRNA isoform expression. The T cell ...

Neuropeptide Y (NPY)-expressing neurons in the arcuate nucleus of the hypothalamus are part of a neuroendocrine feedback loop that regulates feeding behavior and glucose homeostasis. NPY neurons sense peripheral signals ...

Influenza A virus infects 5-20% of the population annually, resulting in ~35,000 deaths and significant morbidity. Current treatments include vaccines and drugs that target viral proteins. However, both of these approaches ...