The two principal gonadotropins are luteinizing hormone &lpar;LH&rpar; and follicle stimulating hormone &lpar;FSH&rpar;&period; Both hormones consist of two peptide chains&comma; an alpha chain and a beta chain&comma; linked by Hydrogen bonds and van der Waals forces&period; LH and FSH share nearly identical alpha chains&comma; while the beta chain provides specificity for receptor interactions&period;A third human gonadotropin is human chorionic gonadotropin &lpar;hCG&rpar;&comma; produced by the placenta during pregnancy&period;

Mechanism&colon;

Gonadotropin receptors are embedded in the surface of the target cell membranes and coupled to the G-protein system&period; Signals triggered by binding to the receptor are relayed within the cells by the cyclic AMP second messenger system&period;Gonadotropins are released under the control of gonadotropin-releasing hormone &lpar;GnRH&rpar; from the arcuate nucleus and preoptic area of the hypothalamus&period; The gonads - testes and ovaries - are the primary target organs for LH and FSH&period; The gonadotropins affect multiple cell types and elicit multiple responses from the target organs&period; As a simplified generalization&comma; LH stimulates the Leydig cells of the testes and the theca cells of the ovaries to produce testosterone &lpar;and indirectly estradiol&rpar;&comma; while FSH stimulates the spermatogenic tissue of the testes and the granulosa cells of ovarian follicles&period;

Diseases&colon;

Gonadotropin deficiency due to pituitary disease results in hypogonadism&comma; which can lead to infertility&period; Treatment include administered gonadotropins&comma; which therefore work as fertility medication&period; Such can either be produced by extraction and purification from urine or it can be produced by recombinant DNA&period;Failure or loss of the gonads usually results in elevated levels of LH and FSH in the blood&period;

Description &colon;

HMG is produced from a sterile preparation of placental glucoprotein urine of post-menopausal women&period; The hMG is purified by proprietary chromatographic techniques&period;Physical Appearance&colon; Sterile Filtered White lyophilized &lpar;freeze-dried&rpar; powder&period;

Formulation&colon;Lyophilized from a concentrated &lpar;1 mg&sol;ml&rpar; solution in water containing no additives&period;

Solubility&colon;

It is recommended to reconstitute the lyophilized hMG in sterile 18MO-cm H2O not less than 100 g&sol;ml&comma; which can then be further diluted to other aqueous solutions&period;

1&period; Quality&colon; Our company is a professional production of hormone intermediates for many years&comma; our products have exported to Germany&comma; Spain&comma; UK&comma; USA&comma; Australia&comma; Middle East&comma; and so on other country&comma; and we have got very good feedback from our customers&comma; you can trust us&period;

3&period; Service&colon; Best service with after-sales service to all clients&period;

4&period; Delivery&colon; Package will be shipped with 3days after payment&period; We can send it via HKems&comma; EMS&comma; HK Air Post&comma; DHL or other method&period; We have a professional and stable logistics&comma; and we can deliver the package smoothly around 3 to 5 days&period;

Our process&colon;1&rpar; Contact me about what you need and your quantity&comma; we will quoted you details&period;2&rpar; Finish the payment&period;3&rpar; We will arrange to send parcel out within 3days after payment&comma; when tracking number updates&comma; we will email you&period;4&rpar; Parcel delivered&period;

About us&colon;Changzhou General Import and Export Corporation&period; is a professional manufacturer and exporter that is concerned with the research&comma;production and trading of pharmaceutical materials&comma;including steriod series piperazidine series&comma; pyrimidine series and other interrelated products&period; We are situated in Xinbei District&comma;Changzhou City&comma; Jiangsu Province&comma; China&period; Changzhou General close to the Beijing-Shanghai Railway&comma;Shanghai-Nanjing Express Way and Changzhou Airport&period; It is about an hour to Shanghai and Nanjing by high speed train&period;