Codergocrine, aka Hydergine, has been used to treat dementia and age-related cognitive impairment, it is also used as a nootropic, improving cognition and memory. The interesting thing is that the mechanism of action of it is a dual effect on central monoaminergic neurotransmitter systems, compensating for both hyperactivity and deficits of the adrenergic, serotoninergic and dopaminergic systems. The compound also appears to have a normalising effect on the power of electroencephalogram frequencies, and may improve cerebral metabolism.

I will copy some parts of many articles about this substance that i think it can be helpful for us:

'' Co-dergocrine mesylate also has marked affinity for postsynaptic dopamine D1-receptors, and presynaptic dopamine D1- and D2-receptors where it has predominantly agonist activity. However, there is some evidence for a mixed agonist/antagonist effect at dopamine receptors. For example, co-dergocrine mesylate stimulated rat striatal cyclic-adenosine monophosphate (cAMP) formation in a dose dependent manner (a D\-receptor response) suggesting an agonist effect, while the drug diminished the effect of high dopamine concentrations (approximately 20 mg/L) on cAMP formation indicating an antagonist effect. Evidence of the partial D2- receptor agonist effects of co-dergocrine mesylate is also provided by its effects on prolactin levels in humans. ''

'' It is now recognised that co-dergocrine mesylate has marked agonist activity at 5-HT1- and 5-HT2-receptors of rat frontal cortex membranes, although in the presence of high serotonin concentrations the compound has antagonist activity. An agonist action of co-dergocrine mesylate on the serotoninergic system has also been demonstrated by its direct effect on the sleep cycle, including alterations in the sleep-time awake cycle, and reduction of the number (but not duration) of REMsleep phases. Thus, there is a theoretical basis for suggesting administration of co-dergocrine mesylate may improve impaired behavioural functions in humans. ''

'' Dose-related increases in the numbers and surface area of cholinergic receptors have been observed in elderly rats given oral co-dergocrine mesylate ''

'' Co-dergocrine mesylate may, however, have an indirect effect on the central cholinergic system via its effect on central cAMP metabolism and subsequent attenuation of age-related reductions in acetyl-coenzyme A activity and hence acetyl choline synthesis ''

'' Co-dergocrine mesylate also enhanced self-stimulation and spontaneous motor activity but had no effect on motor activity or induction of stereotype behaviour in other rat behavioural tests . The effects on self-stimulation and spontaneous motor activity corresponded to increased levels of noradrenaline and dopamine, and decreased serotonin levels in the pons-medulla, indicating that the behavioural effects of co-dergocrine mesylate may be associated with neurochemical changes ''

'' Co-dergocrine mesylate appears to have a dual effect on these neurotransmitter systems compensating for both under- and over-activity of adrenergic, dopaminergic and serotoninergic systems, and thus may have a normalising effect on neurotransmitter disturbances of elderly patients with cognitive impairment. Evidence from animal studies also suggests co-dergocrine mesylate may improve cerebral metabolism and may compensate for a pathological decline in glucose turnover ''

'' At D1 receptors, hydergine has mixed agonist/antagonistic properties. In the absence of dopamine, it acts as an agonist, and in the presence of high concentrations of dopamine as an antagonist ''

-

It can be a good thing but i dont know if it is enough for us, the bad thing seems to be this substance requires a high dose and for long time, most of the studies use about 4.5mg - 6mg day for 3 months, although higher doses were tested and there was no toxicity.

'' Overall, ergoloid mesylates were more effective than placebo. However, the effect in patients with possible Alzheimer's dementia was very modest at best. The dose-response relation suggests that potentially effective doses may be higher than that currently approved. ''

'' Even with the wealth of compelling findings obtained in dozens of animal and human trials, some researchers questioned hydergine's efficacy in treating advanced cognitive decline. In response to this uncertainty, meta-analyses were performed to statistically evaluate the data obtained in multiple human trials. Two of these overviews, (one evaluating 21 trials and another analyzing 47 trials) concluded that "hydergine shows significant treatment effects" especially when initiated early and at higher doses than the FDA-approved 3 mg dose. One reason why some trials reported only modest improvements in hydergine-treated patients is simply that the dose used was too low and therefore, ineffective. In Europe, the drug is prescribed at doses of at least 9 mg per day, but in the US, the recommended starting point is 3 mg. Since the drug exhibits low, if any, toxicity, and higher quantities have been linked with greater efficacy, it seems counterproductive (and unscientific) to use the lower dose. The four clinical studies reviewed earlier, in which significant improvements were obtained, used oral doses of 4.5 mg to 6 mg ''

In my country it's sold only with 30ml 1mg/ml , what disturbs me because i had to buy 8 units of it and it wont last much more than 1 month. I would like to see any results in 1 month before buying more to continue, I dont know which dose i will use yet, i think about 6mg, i already bought and it's coming, i think i start in 1 week.

I found only one person that used it here in forum but there is no details about, and he used mixed with other things. My idea now is trying new things, that were not tested yet, or poorly tested, i am tired of trying almost all of the known stuffs said in this forum, and if we didnt find a cure yet, that's because it's not known or tested. I am medical student and i have some facilities to get drugs, although codergocrine and many other drugs are sold freely to anyone here in Brazil.

For those who likes to read medical articles, many of these are locked, you would have to pay to read, but there is a site called Sci-Hub ( https://sci-hub.tw/ ) when you put the link or the name of any article and you can read the full article for free, i dont know if all of you knew this.

i'm on 5° day , taking 10mg/day and together with vinpocetine 20mg/day, another nootropic, that improves brain metabolism, enhances cAMP and promotes brain blood flow, they act in different ways then i thought combine could be a good thing. I improved, my cognition is much better, the brain fog was reduced, my mood is good and i am starting to feel emotions again, i cried two times last two days thinking in my girlfriend (although it's not a good emotion, i liked because i am normaly unable to feel even sad) , musics seens more enjoyable too. I would say i got 35% better in these areas, far from a cure.

But my libido and erections is still a shit, unfortunately it didnt improve... but it's few time, let's see