Abstract

Background

Techniques for measuring protein abundance are rapidly advancing and we are now in
a situation where we anticipate many protein abundance data sets will be available
in the near future. Since proteins are translated from mRNAs, their expression is
expected to be related to their abundance, to some degree.

Results

We have developed a web tool, called PARE (Protein Abundance and mRNA Expression;
http://proteomics.gersteinlab.orgwebcite), to correlate these two quantities. In addition to globally comparing the quantities
of protein and mRNA, PARE allows users to select subsets of proteins for focused study
(based on functional categories and complexes). Furthermore, it highlights correlation
outliers, which are potentially worth further examination.

Conclusion

We anticipate PARE will facilitate comparative studies on mRNA and protein abundance
by the proteomics community.