A study from the Cardiac Regeneration and Ageing Lab, School of Life Science, Shanghai University, Shanghai 200444, Chinashows that “miR-29b contributes to multiple types of muscle atrophy.” This research paper was published, in the 25 May 2017 issue of the journal “Nature communications” [One of the best research journals in Biology with an I.F of 11.329 ], by Prof. Xiao J, Li Jand others.

Given: (1) that Muscular dystrophy/wasting is a degenerative disease; (2) that Muscular dystrophy/wasting also occur due to a number of pathophysiological conditions, including cancer, denervation, disuse and fasting ; (3) that there is no permanent cure for muscular dystrophy; (4) the life-long discomfort and the medical care required to alleviate pain-associated (muscle weakness) with muscular dystrophy; and (5) the global economic cost spent for muscular dystrophy is enormous, there is an urgent need to find: (i) a way to rejuvenate muscle (satellite) stem cells that were lost in Muscular dystrophy; (ii) a cheaper alternative to the existing expensive drugs; and (iii) a side-effect-free natural product-based drug.

This study suggests, for the first time, an Electrical acupuncture-based therapy for Muscular dystrophy.

Hydrogen-rich water therapy, by increasing the expression of its target genes, it may decrease the expression of MiR-29b etc. (Fig. 1). Thereby, it may: (1) increase the expression of IGF-1, PI3K(p85a) and B-Myb; (2) increase phosphorylations of AKT (Ser-473), FOXO3A (Ser-253), mTOR and P70S6K; (3) decrease the expression of Forkhead Box O3 (FOXO3) and its downstream target genes such as MAFBX etc.,; and (4) promote the expression of myosin isoforms, such as Myh7; (vii) augment muscle regeneration, growth, and proliferation.

Thus, by subjecting myocardial patients to Hydrogen-rich water therapy, one may inhibit muscular dystrophy.

Based on this finding, physicians/myologists/orthopaedicians may consider adopting Hydrogen-rich water therapy (figure 1) in the treatment of muscular dystrophy. [easy_payment currency=”USD”]

Figure 1. Mechanistic insights into how Hydrogen-rich water therapy, by decreasing the expression of MiR-29b, may promote regeneration of muscle cells and attenuate muscular dystrophy