Microbiome in Embryonic Implantation and Implantation Failure

Abstract

The latest advances in microbial detection with next-generation sequencing have enabled the study of low biomass microbiomes of tissues and organs previously considered sterile, such as the endometrium. Most recently an abnormal endometrial microbiota has been associated with implantation failure, pregnancy loss, as well as other gynecological and obstetrical conditions. Further investigation of the reproductive tract microbiome in physiological and pathological conditions will allow researchers to unravel the role of bacterial communities and its function in the uterine cavity before, during, and after pregnancy. As knowledge of the reproductive tract microbiome evolves, there are data which suggest this may be an effective future tool for improving reproductive outcomes in infertile patients.