Mr. Youssef, currently one of the most widely watched comedians in the Arab world, was taken off air just minutes before the second episode of the season was scheduled to air. The decision comes a week after influential comedian delivered some pointed jabs at the Egypt’s powerful, ultra nationalist military in his first episode of the season.

Just before the station announced the decision, Al Shourouk, an Egyptian independent daily newspaper, reported that Mr. Youssef had left Cairo for Abu Dhabi only hours before the show was scheduled to air.

In his show, Mr. Youssef typically targets both sides of Egypt’s divided political scene. Mr. Youssef and members of his show’s media team were not available for immediate comment. Shady Alfons, a comedian and cast member on the show, told The Wall Street Journal that he and the team were made aware of the decision “just like everyone else” watching TV that evening.

The TV station, which is funded by some of the most influential and wealthiest investors in Egypt, issued a statement on its network saying it had decided to suspend Mr. Youssef’s “Al Barnameg,” or “The Show” after content planned for the night’s episode had “violated what had been agreed upon” with the station.

Mr. Youssef’s return to the air last month was anticipated by millions in the Arab world. They were waiting to see just how far the satirist would go in Egypt’s current tense political atmosphere. Many viewers argued that Mr. Youssef would tone down his criticism at a time that Egypt’s military-backed government was supported by widespread, ultra nationalist sentiment.

Despite despite fears of a crackdown on free speech, Mr. Youssef made fun of the country’s tense politics and military fervor on his show’s first episode last week. He particularly slammed the widespread public obsession with the country’s top military General Abdel Fattah Al Sisi, who has been compared by Egyptians to former ultra nationalist president Gamal Abdel Naser.

“I am afraid that we’ll replace religious fascism with a new fascism in the name of [preserving] the country and national security,” Mr. Youssef said on his show. “Will the new authority and the one that will follow it be tolerant and accept sarcasm?”

After receiving scathing comments from anxious Arab viewers criticizing their decision to suspend Mr. Youssef’s show Friday, the station then tweeted a series of statements claiming that the show would be suspended indefinitely due to “technical and business” issues. Many viewers on social media called on viewers to boycott the channel.

Mr. Youssef, a heart surgeon gone comedian, saw his popularity soar last year as he routinely mocked former Islamist president Mohammed Morsi and his Muslim Brotherhood party.

Since before Mr. Morsi was ousted by a military-backed uprising four months ago, the Egyptian comedian had been off air on a break.