I had brown spotting and low progesterone with my first child at 6 1/2 weeks. I took prometrium throughout my first trimester and everything progressed very smoothly and my daughter is a very healthy 6 year old.

My doctor told me that prometrium would not be a "miracle" pill, but if that my baby was healthy, it could help support the pregnancy, but if my progesterone was low because I was starting to miscarry (presumably an unhealthy baby), the prometrium wouldn't help.

Since then, I've had 6 more pregnancies. I have taken prometrium with all of them....3 were early miscarriages (around 5-6 weeks), 2 were my other two living children, and one is my current pregnancy.

My comfort in taking prometrium was that I felt like I was doing everything I could and the rest was out of my hands. My children have had no ill effects from the prometrium.