Methods: : Six standard radial scans centered on the fovea were done byStratusOCTTM in 80 healthy eyes (35±13 years) and 28eyes with diabetes mellitus (DM) with no or minimal diabeticretinopathy (MDR) (21 eyes no DR [DM; 31±7 years] and7 eyes with minimal DR [MDR; 63±18]) on biomicroscopy.Automatic layer segmentation was performed using OCT RetinalImage Analysis software (OCTRIMA). Mean values of reflectanceand retinal thickness (RT) of the macula, RNFL, GCL+IPL, INL,OPL, ONL, IS/OS and RPE in the fovea, pericentral and peripheralrings in the DM and MDR patients were compared with the meanvalues in healthy controls. Mean RT measurements in the groupsHoodie Hoodie Religion Wholesale Religion Hoodie Religion Black Wholesale Black Wholesalewere compared using ANOVA followed by Dunnett-post hoc analysis.A modified p value of <0.001 was considered statisticallysignificant.

Results: : No statistically significant thickness changes of the ONL, RPEFreud shirt Weekday red Print Pictor T Black S4x5aqand macular RT were found in the fovea (R1). We found a significantreduction in the pericentral and peripheral regions of the RNFL(30.8±2.1 vs. 21.8±6.5µm and 56.6±4.8Religion Black Black Hoodie Religion Religion Wholesale Wholesale Hoodie Hoodie Wholesalevs. 33.6±11.0µm, respectively, p<0.001 bothcases), and a significant reduction in the GCL+IPL complex thicknessin the pericentral region of the MDR group compared to controls(86.2±5.1µm vs. 72.2±8.8µm, p<0.001).Also, macular RT was significantly reduced in the pericentralring of the MDR group compared to controls (308.5±9.3µmvs. 288.6±19.5µm, p<0.001). Local reflectanceof each layer relative to each other was moderately stable withinthe retina for DM and control groups. However, this stable reflectancepattern was not present for the RNFL in eyes with MDR.

Conclusions: : We found reduced RNFL thickness in the pericentral and peripheralregions and reduced thickness of GCL+IPL complex in the pericentralregion of the macula. Accordingly, macular RT was reduced inthe pericentral region of the macula. Our results support theview of neurodegeneration in diabetes in the early stage ofDR which seems to involve the RNFL and GCL layers mostly, leadingto reduced macular thickness as reported previously. The strengthof this study compared to other studies is the OCTRIMAsubanalysisand quantification of the local variations of the intraretinallayers. Local measurement of the structural and optical propertiesof the retina by OCT appears to be a proper index for earlyDR detection.