An event-related fMRI using virtual performance of a
hand manipulation test for elderly was designed to
investigate the neural basis of potential cognitive
decline. Precise timing of three visuo-motor operations
to transfer a target object to the goal was recorded by
using turnkeys to define the time series of the events.
It was demonstrated that activation of dorsal visual
pathway was augmented in the elderly group when the
visuo-motor performance was switched, suggesting
thatswitching cost may be a more sensitive index as
age related change than the other cognitive processing
used for three steps of visuo-motor task.

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