It's a jungle out there for Blu, Jewel and their three kids after they're hurtled from Rio de Janeiro to the wilds of the Amazon. As Blu tries to fit in, he goes beak-to-beak with the vengeful Nigel, and meets the most fearsome adversary of all: his father-in-law.

Fed up with being targeted by the neighborhood bully, 10-year-old Lucas Nickle vents his frustrations on the anthill in his front yard ... until the insects shrink him to the size of a bug with a magic elixir. Convicted of "crimes against the colony," Lucas can only regain his freedom by living with the ants and learning their ways.

Placed in a foster home that doesn't allow pets, 16-year-old Andi and her younger brother, Bruce, turn an abandoned hotel into a home for their dog. Soon other strays arrive, and the hotel becomes a haven for every orphaned canine in town. But the kids have to do some quick thinking to keep the cops off their tails.

A half-striped zebra is blamed for the drought and leaves his herd in search of his missing stripes. He is joined on his quest by an overprotective wildebeest and a flamboyant ostrich; they defeat the tyrannical leopard and save his herd.

The adventure unfolds as Tom Sawyer and Huck Finn - Tom's friend from the streets - witness a murder in the graveyard. Tom and Huck flee to Jackson Island and make a pact never to tell anyone about the incident. However, when the good-natured Muff Potter, who has been blamed for the murder is sentenced to death by hanging, Tom breaks his promise and returns to exonerate Muff Potter. In jun Joe, the actual murderer, makes a hasty exit from the courtroom during the trial. A short time later, Tom and Huck find references to a treasure and have to face In jun Joe again.