The painful rheumatic condition gout is often associated with the big toe, but Mayo Clinic has found that patients at highest risk of further flare-ups are those whose gout first involved other joints, such as a knee or elbow.

In other findings, Mayo discovered a clue to why lupus tends to be worse in African-Americans, chronicled erratic blood pressure in rheumatoid arthritis patients found gout-like deposits in the joints of people with advanced osteoarthritis and examined why smoking doubles the risk of developing rheumatoid arthritis.