Sex Differences in Neurobiology, Behavior and Disease

Though the existence of two sexes is a fundamental characteristic of nearly all animal species, the way biological sex brings about sex differences in the brain and behavior is poorly understood. Moreover, susceptibility to a host of human neurological and mental health disorders is strongly influenced by gender, but in most cases the biological bases for these differences remain opaque. Our research uses a simple, experimentally tractable model system – the small soil nematode C. elegans – to shed light on the genetic underpinnings of sex differences in neural development, behavior, and disease susceptibility.

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