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Engineered Probiotics Prevent Obesity in Mice.

Weight gain can be prevented with engineered probiotics, even when paired with a high-fat diet, at least in mice, a new study shows. Researchers genetically modified probiotic bacteria to produce a hunger-suppressing compound called NAPE, which is normally released by the cells in the small intestine after a meal and signals the brain to reduce food intake.

Dr. Sears Comments:

Natural agents that increase satiety should be the next major area of obesity research. There are a lot of drugs that have hsd increased satiety in the past (cocaine, amphetamines, Fen-Phen, etc.), but they all had some side effects.

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