Drug interaction is a major cause of morbidity and mortality that is part of the drug-related
problems in patients who need to be seen in its many pathologies. Results may be a greater
than expected response, a decrease of the effectiveness of one or both drugs or unanticipated
toxicity.
Objective:To describe drug interactions in patients hospitalized in the Hospital Medicine
Service Essalud m- Loreto, in the months ofFebruary to May 2011.
Methods: A descriptive, prospective, correlational study time was 04 months, which
included a total of 268 patients of both sexes, and age groups ranging from 18 to over age.
Treated at the Hospital Medicine Service Essalud m - Loreto. Data collection was
conducted through interviews, selecting patients randomly within a defined time.
Key Findings: It was determined that a total of 268 patients, 58.2% showed a possible drug
interaction, of which 9.5% was Clinically Important, the average age was 56 years,
predominantly female appearance at the 51.1 %. The average number of drugs prescribed
was 6.5, with 285 combinations of possible drug interactions of which 4.2% of them were
between Diclofenac + Paracetamol 500 mg and 75mg Nifedipine 1 Omg + Theophylline 250
mg and of 570 prescribed drugs in patients with possible interaction 32.8% of they are
located within the Muscle System - Skeletal System under Classification, anatomical
therapeutic chemical and the most frequently prescribed drug was Diclofenac interactions to
8.6% depending on the type of interaction the rate was 51.6% Pharmacokinetic.
Conclusions: There is a high frequency of drug interaction in patients in the medical
service, with important clinical manifestations that require therapeutic measures. Research in
this field are still scarce and isolated nationally, so it is imperative to conduct studies to
report, document, analyze and report on drug interactions in hospitalized patients in the
various departments of the hospitals.