This open-label randomized 2arm study will determine the emergence of viral resistance in patients with seasonal influenza A infection treated with Tamiflu. Eligible patients </=5 years of age will be randomized to receive Tamiflu at either standard dose (30-75mg orally bid) or double dose (60-150mg orally bid) for 5 days. Target sample size is >100.

onset of symptoms of influenza (fever, at least one respiratory symptom) </=48 hours

Exclusion Criteria:

clinical suspicion of infection with a respiratory virus other than influenza

suspicion of invasive bacterial infection

evidence of poorly controlled underlying disease

known immunosuppression

Contacts and Locations

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To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below.
For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00949533