Biographical

Larry S. Schlesinger, MD, Samuel Saslaw Professor of Medicine is Chair of the Department of Microbial Infection and Immunity, and Director of the Center for Microbial Interface Biology. He also directs the Medical Scientist Training Program (MD/PhD). He has joint appointments in the College of Public Health and Departments of Microbiology, Veterinary Biosciences, and Molecular Virology, Immunology and Medical Genetics. Dr. Schlesinger was recruited to OSU from the University of Iowa in 2002. His laboratory is focused on human mononuclear phagocyte interactions with Mycobacterium tuberculosis and more recently Francisella tularensis. Current work in the lab is focused on the role of mycobacterial cell wall lipoglycans produced in vitro and in vivo (including glycomics and lipidomics) in regulating the host inflammatory response (e.g. macrophage NODs, PPARγ), the role of core enzymes in generating mycobacterial GDP-mannose for the production of cell wall lipoglycans (bacterial knock-out and over-expression systems), pulmonary models of the innate immune response to mycobacteria (role of surfactant proteins), and identifying host susceptibility factors for tuberculosis by using functional genomics.

Editorial Activities

present

The Journal of Immunology, Infection and Immunity, Immunity, The Journal of Infectious Diseases, Journal of Clinical Immunology, Spine, American Journal of Physiology: Lung Cellular and Molecular Physiology, Trends in Microbiology

present

The Journal of Clinical Investigation, The Journal of Leukocyte Biology, Molecular Microbiology, JAMA, Proceedings of the National Academy of Sciences, Journal of Experimental Medicine, Journal of Biological Chemistry, Nature Genetics

"â€œInterplay of M. tuberculosis and macrophages in the human respiratory system.â€�." Presented at Public Health Research Institute Center at UMDNJ New Jersey Medical School, Newark, NJ. (October 2009)

""Annual Program Meeting of the Tuberculosis Research Unit"." Presented at Case Western Reserve University, Cleveland, OH. (October 2009)

"Interplay of M. tuberculosis and macrophages in the human respiratory system." Presented at Public Health Research Institute Center at UMDNJ New Jersey Medical School, Newark, NJ. (October 2009)

"Interplay of M. tuberculosis and macrophages in the human respiratory system.." Presented at the 91st Annual Meeting of the Conference of Research Workers in Animal Diseases (CRWAD)., Chicago, IL. (December 2010)