Regular season

May 10, 1981: Charlie Lea pitched a no hitter against the San Francisco Giants, defeating them 4-0 at Olympic Stadium. The last out was recorded by Andre Dawson in center field. Lea would go on to shut out the Giants again a week later on four hits in San Francisco for good measure.

October 11, 1981 - Steve Rogers defeats Steve Carlton of the Phillies 3-0 in a pitchers duel to win the National League Division Series. Rogers drove in two of the three Expos runs to boot singling home Larry Parrish and Chris Speier in the fifth inning. The Expos advance to play the Dodgers who defeated the Astros. Rogers previously defeated Carlton in game one of the series as well.

October 19, 1981: Blue Monday. In the decisive Game 5 of their only National League Championship Series, the Expos were defeated at home, 2-1, by the Los Angeles Dodgers. Tim Raines opened the bottom of the first with a double against Cy Young Award-winning rookie sensation Fernando Valenzuela and scored on an Andre Dawson double play ball. Valenzuela held the Expos scoreless the rest of the way, however, and the Dodgers tied the game at 1 in the top of the fifth with two hits, a wild pitch and an RBI ground out off Expo starter Ray Burris. The teams remained tied until the top of the ninth, when Expo manager Jim Fanning made a risky decision to relieve Burris with Game 3 winner Steve Rogers. Struggling closer Jeff Reardon was throwing alongside Rogers in the bullpen at the time, but Fanning elected to summon his ace. Rogers retired Steve Garvey and Ron Cey in order, but outfielder Rick Monday homered to put Los Angeles ahead, 2-1, and crush the Expos' hopes of advancing to the World Series. Two-out walks from Gary Carter and Larry Parrish were all that the Expos could muster in the 9th, as Bob Welch preserved the one-run Dodger victory. The Expos lost the NLCS, 3-2, and never returned to the postseason.