The species is commonly referred to as the giant freshwater pufferfish due to its massive size, growing to a length of 67 cm (26 inches). As such, these fish are difficult to adequately house in home aquaria since they require a very large tank and appropriately scaled water filtration.

Like all of its relatives, the Mbu puffer is capable of inflating itself with water or air when stressed or otherwise frightened. It feeds on smaller fish, mollusks and crustaceans. Species kept in captivity require a varied diet consisting of crunchy foods to help ensure good health and to prevent tooth overgrowth.