A Study of ABT-652 in Adults With Osteoarthritis Pain of the Knee

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government.
Read our disclaimer for details.

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

Ages Eligible for Study:

40 Years to 75 Years (Adult, Senior)

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

No

Criteria

Inclusion Criteria

History of OA of the knee joint and meeting American College of Rheumatology (ACR) Clinical and Radiographic criteria,

Pain score as required by the protocol at Screening and Baseline

Willing to washout of analgesics and to follow treatment plan, visit schedules and study procedures.

Exclusion Criteria

History of sensitivity to histamine medications, acetaminophen (paracetamol), or non-steroidal anti-inflammatory drugs (NSAIDs)

Active gastrointestinal (GI) disease, GI bleeding or GI ulceration, or history of GI bleeding or GI ulceration in the last 6 months

History of major psychiatric disorders

Diagnosis of rheumatoid arthritis, autoimmune disorder, arthritis other than osteoarthritis involving the study joint, or other painful syndrome that could interfere with the assessment of pain at the study joint

Any cardiac, respiratory, neurological or other medical condition or illness that is not well controlled with treatment