Adults born with heart defects have a substantially higher risk of stroke

3:14 November 24, 2015

Study Highlights

Adults with congenital heart defects have considerably higher rates of stroke compared to the general population.

Heart failure, diabetes and recent heart attacks were the strongest predictors of stroke caused by a blocked artery.

DALLAS, Texas — Adults with congenital heart defects have substantially higher rates of stroke compared to the general population, according to research published in the American Heart Association journal, Circulation.

A congenital heart defect is a heart abnormality present at birth. These defects encompass a wide range of disease entities, some presenting as life threatening conditions soon after birth, others only developing symptoms later in adulthood.

Seeking to uncover the frequency, risk and strongest predictors of stroke, researchers analyzed stroke data on 29,638 congenital heart disease patients, 18-64 years old, and compared rates with those observed in the general population of Quebec, Canada. They found:

Stroke rates caused by a blood clot blocking a cerebral artery, known as ischemic stroke, was roughly 9 to 12 times higher in adults with congenital heart defects before the age of 55, and 2 to 4 times higher in patients between the ages 55 and 64.

Stroke rates from a bleed in the brain, known as hemorrhagic stroke, was 5 to 6 times higher in adults with congenital heart defects before the age of 55, and 2 to 3 times higher in patients between the ages of 55 and 64.

8.9 percent of men and 6.8 percent of women with congenital heart defects experienced at least one stroke before age 65.

Heart failure, diabetes and recent heart attacks were the strongest predictors of ischemic stroke in adults with heart defects.

“We knew there was a connection between heart failure and stroke in patients with heart defects, but we were surprised to discover it was the strongest predictor,” said Ariane Marelli, M.D., M.P.H., study senior author and professor of medicine at McGill University in Montreal, Quebec, Canada. “Our study also suggests that other well-known risk factors for stroke, such as irregular heartbeat and high blood pressure may be under-detected in patients born with a heart defect,” said Jonas Lanz, M.D., M.Sc., first author of the study and research fellow at McGill University.

Because adults with heart defects are more susceptible to strokes, Marelli stressed the importance of regular visits to a cardiologist to help reduce the risk through timely detection and treatment of modifiable risk factors.

Stroke is the fifth leading cause of death in the United States, claiming nearly 129,000 lives every year, according to the AHA/ASA.

“Patients, their families and friends should also learn the F.A.S.T. signs to recognize stroke and understand how to get professional medical help quickly if they believe they are having a stroke,” Marelli said.

Other co-authors of the study are James M Brophy, M.D., Ph.D.; Judith Therrien, M.D.; Mohammed Kaouache, Ph.D.; and Liming Guo, M.Sc., Author disclosures and funding are on the manuscript.

Additional Resources:

Ischemic stroke animation and brain/clot illustrations are available on the right column of this release link http://newsroom.heart.org/news/adults-born-with-heart-defects-have-a-substantially-higher-risk-of-stroke?preview=54960f0162f2b8417b34e9746e0171cd After Nov.23, 2015, view themanuscript online. Some heart birth defects may increase children’s heart infection risk Follow AHA/ASA news on Twitter @HeartNews. For updates and new science from JAHA, follow @JAHA_AHA.

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Statements and conclusions of study authors published in American Heart Association scientific journals are solely those of the study authors and do not necessarily reflect the association’s policy or position. The association makes no representation or guarantee as to their accuracy or reliability. The association receives funding primarily from individuals; foundations and corporations (including pharmaceutical, device manufacturers and other companies) also make donations and fund specific association programs and events. The association has strict policies to prevent these relationships from influencing the science content. Revenues from pharmaceutical and device corporations are available at www.heart.org/corporatefunding.

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