PRINTED FROM OXFORD SCHOLARSHIP ONLINE (www.oxfordscholarship.com). (c) Copyright Oxford University Press, 2020. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 07 June 2020

The challenge of assessing complex gene– environment and gene–gene interactions

The challenge of assessing complex gene– environment and gene–gene interactions

Peter Kraft

David J. Hunter

Publisher:

Oxford University Press

DOI:10.1093/acprof:oso/9780195398441.003.0009

This chapter discusses the study of gene-environment and gene-gene interactions in genetic epidemiology. It starts with a review of the definition of statistical gene-environment interaction, which is what is typically measured and reported in genetic association studies, and contrasts this with specific theoretical and general intuitive models for biologic interaction. It then describes how these concepts can be extended to the study of gene-gene interactions, and reviews available study designs, with particular emphasis on estimating joint gene-environment and gene-gene effects.

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PRINTED FROM OXFORD SCHOLARSHIP ONLINE (www.oxfordscholarship.com). (c) Copyright Oxford University Press, 2020. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 07 June 2020