Robert W. Sobol, Ph.D.

Chief, Molecular and Metabolic Oncology Program

Research Interests:Research in the Sobol lab focuses on the mechanism of base excision repair, PARP and NAD+ metabolism in human cells and the convergent role of these enzymes and pathways in response to environmental Geno toxins and chemotherapy. A major goal in the lab is to use biochemical, genetic and imaging modalities to study the protein complexes of the base excision repair pathway that respond to DNA damage induced by Geno toxins and chemotherapy and how this pathway affects the regulation of cellular metabolism via ADP-ribosylation signaling and alterations in NAD+ metabolism. Dr. Sobol has been continually funded by grants from NIH (NCI) as well as those from the American Cancer Society, the Susan G. Komen Breast Cancer Foundation, the Brain Tumor Society, the Pittsburgh Foundation and the Elsa U. Pardee Foundation for Cancer Research, among others.