Causes of death among persons diagnosed with hepatitis C infection in the pre and post DAA era in England: A record linkage study

Causes of death in England among persons with the diagnosis of HCV were determined through record linkage. Linking persons ≥1yrs with anti-HCV/HCV-PCR tests reported to PHE sentinel surveillance during 2002-2016 to death registrations from the Office for National Statistics during 2008-2016, researchers identified death of 8.6% of the 204,265 with evidence of HCV. The leading underlying causes of death were external causes (accidental poisoning from drugs) and liver disease (end stage liver disease, liver cancer, hepatitis, alcohol and non-alcohol related); 18% and 34.5%, respectively. Persons with evidence of HCV had a lower median age of death than the general population (53 years vs 81 years). New HCV treatments have led to a relative reduction in liver–related deaths in 2016 compared to 2015. This study supports that for monitoring all-cause mortality among those with HCV and quantifying underreporting of HCV in death registrations, data linkage between laboratory diagnosis and deaths data is an important tool.

The study is aimed at assessing the safety and immunogenicity of HCV prime-boost vaccinations ChAd3-hliNSmut and MVA-hliNSmut, administered intramuscularly in healthy volunteers and DAA treated patients. To read the entire study, click here Share This PageFollow Us … Continue reading → The post The study is aimed at assessing the safety and immunogenicity of HCV […]

The purpose of this study is to evaluate the efficacy and tolerability of DAA-based regimens in the clinical practice in HIV/HCV-coinfected patients. Hypothesis: The efficacy and tolerability of all DAA-based regimens in the clinical practice is different to what is … Continue reading → The post Real-life Security and Efficacy of DAA-based Therapy in 1,000 […]