The purpose of the study was to investigate occupational stress among Hong Kong factory workers (N=138) using the shortened version of the Occupational Stress Indicator (OSI)-2, to compare it with a sample of factory workers (N=342) in China. The results showed that the reliabilities and predictive validity of the OSI-2 subscales and other subscales used for the study were reasonably high. Workers in China scored significantly higher in the means of job satisfaction, mental and physical well-being, satisfaction on environmental condition, and perceived work pressure than Hong Kong workers. The main sources of stress and the coping strategies that were most frequently used to tackle stress were different in the two groups. In addition, the predictors for job strain were various and many in the two groups. The logical relationships between job satisfaction, mental well-being and physical well-being that were found in the two groups have provided support to the findings obtained in Western countries. Further, coping had no direct or moderating effect on the stressor-strain relationships in either of the two groups.