Effect of Dietary Calcium and Phosphorus on Toxicity of Lead in the Rat: Rationale of Phosphate Therapy.

Abstract

The rationale of the use of calcium compounds in the treatment of lead poisoning depended upon the following facts: First, the solubility of lead phosphate was found to be analogous to that of calcium phosphate; hence it was believed that lead might be deposited in bones in the same manner that lime salts are. Second, it was believed that the deposition of lead in the bones could be increased by furthering the process of calcification through the administration of calcium. Third, the prompt relief of lead colic through the intravenous administration of calcium chloride was thought to add additional evidence