Search for morphological defects

Choose the stage and click on a term on the list of morphological structures, which will appear upon typing into the respective field.
Optional: Choosing a penetrance of >50% will strongly reduce false positive hits.

Search strategy

The search at iBeetle-Base allows for very specific searches (e.g. “larva, leg,
size decreased”). However, in order not to miss interesting phenotypes, we
recommend initiating your search broadly for defects of the structure and stage
you are interested in (larva, leg). Further, a penetrance of >50% is recommended
in order to increase the portion of reproducible datasets. Next, the list should
be consolidated by browsing the pictures and detailed annotations displayed in
the search results. Interesting results can be marked by checkboxes. Finally,
the respective details pages should be browsed in order to learn more about
additional phenotypes, the gene structure and sequences and its orthologs.

Reproducibility

Highly penetrant phenotypes with a direct phenotype-genotype relationship
(e.g. lethality, wing blistering) were reproducible at a close to 100% rate
in our hands. Regarding processes where the relation between gene function
and phenotype is complex (e.g. embryonic development), the rate of
reproducibility was between 70% and 80%. Reproducibility of low penetrance
phenotypes (<50%) was significantly lower.

auto complete feature. After three letters are typed in the search field, a list of matching values is displayed. Please select one from the list.

list of available structues by clicking on . The list of available structures are displayed hierarchically . The number in parentheses idicate the number of data sets linked to this term in any developmental stage.

Penetrance

Estimated portion of individuals in the preparation showing the selected search term combination.
Phenotypes with penetrance >50% are reproducible with high frequency.

Annotations

not selected

egg

larva

pupa

adult

not selected

>30 %

>50 %

>80 %

max data sets

Optional further specifications

Important note

Be careful with choosing further specifications: You may miss important
phenotypes because morphological phenotypes can be correctly described with
different term combinations.

We recommend to search rather broadly for the morphological structure of
your interest and then reduce the number of hits by browsing through the
pictures.
Phenotypes with a penetrance of 30% are frequently not reproduced,
especially if they come in combination with many additional annotations.

Temporal, local or logical specifications

Altered aspect

Nature of change

not selected

anterior

bilateral

central

complete

distal

dorsal

early

ectopically

late

lateral

median

oblique

oblique

posterior

proximal

unilateral

ventral

not selected

circumference

cleavage

colour

content

cuticularisation

development

differentiation

distance

dv-orientation

egg production:

fertility after larval injection

fluorescence

folding

motility

number

orientation

pattern

pd-orientation

pigmentation/tanning

position

proximodistal-axis

rim

robustness

segmentation/division

shape

size

stage sequence

structure

surface

not selected

bent

bilateral

blistered

broader

constricted

darker

decreased

duplicated

ectopically

elongated

everted (inside-out)

fragmented

fused

incomplete

increased

irregular

lighter

necrotic

not bent

not closed

not fused

not present

posteriorized

present

protruding

radially

rough

rounded

shortened

split

spotted

sticky

swollen

thinner

transformed

with protrusion

without detectable defects

Add new aspect next to the selected one

Add new aspect next to the selected one seachConstraintsHint

Add new aspect next to the selected one

Your search:

Combine searches by clicking the “AND” “OR” “NOT” buttons.
Your current combination of search terms is displayed. Modify the single aspects
by clicking on the respective button, or change the logical combination.
Remove aspects using the “Remove” button.