showed that both MRGPRA3+ and MRGPRD+ neurons from hapten-challenged mice displayed a significantly more depolarized resting membrane potential, decreased rheobase, and greater number of action potentials at twice rheobase compared with neurons

An itching response is mediated in mice by Mrgprd expressed in primary sensory neurons.

Mrgprd+ neurons are nociceptors in the outer epidermis and may respond indirectly to external stimuli by detecting ATP release in the skin

This study demonstrated that Mrgprd influences the excitability of polymodal nonpeptidergic nociceptors to mechanical and thermal stimuli.

MRGPRD Antigen Profile

Protein Summary

seven transmembrane domain G-protein coupled receptor\; most often found in sensory neurons