Email: shivani@mit.edu
3
Department of Medicine,
Brigham and Women's Hospital, Harvard Medical School,
Boston, MA 02115, USA
Email: shiladit@mit.edu
The problem of identifying key genes that are involved in a particular disease is of fundamental importance in
biology and medicine. Given the increasing availability of a variety of gene-related biological data sources, ranging
from microarray expression data to protein-protein interaction data, a promising approach is to use bioinformatics
methods that can analyze this data and rank genes based on potential relevance to a disease; such methods can be