Conclusions

Benzodiazepines and non-benzodiazepines are effective treatments in the management of chronic insomnia, although they pose a risk of harm. There is also some evidence that antidepressants are effective and that they pose a risk of harm.

KEY WORDS

Notes

Acknowledgment

We are grateful to members of the technical expert panel for providing input on the direction of the review.

Financial Support

This study was conducted under contract to the Agency for Healthcare Research and Quality (Contract No.C400_000_021), Rockville, MD., funded by the Office of Medical Applications of Research, National Institutes of Health, Bethesda, MD. The study was presented at the NIH State_of_the_Science Conference on Manifestations and Management of Chronic Insomnia in Adults in June 2005.

Disclaimer

The authors of this article are responsible for its contents, including any clinical or treatment recommendations. No statement in this article should be construed as an official position of the Agency for Healthcare Research and Quality, the Office of Medical Applications of Research or the U.S. Department of Health and Human Services.

Conflict of Interest

The corresponding author declares, on behalf of all authors, that there are no conflicts of interest to disclose.None disclosed

NB participated in writing the proposal; planning, overseeing, and contributing to the systematic review process; and writing and editing the manuscript.

BV participated in writing the proposal, contributed to the systematic review process, performed all statistical analyses, and participated in writing and editing the manuscript.

CF planned and conducted the search strategy, wrote the literature search section and related appendices, and reviewed and edited the manuscript.