Can the information proposed in an application differ from the research initially described in the Letter of Intent (LOI)?

Yes. However, PIs are invited to submit an application based on the information provided in the LOI. Any changes to the following require PCORI's written approval prior to submission:

Principal Investigator

Institution

Study design

Research question(s)

Specific aims

Comparators

Please email pfa@pcori.org regarding information you would like to change or if you have any questions. Due to the volume of requests PCORI received, applicants should submit the request early during the application process.