In vitro and mouse studies suggest pancreatic islet cells
pretreated with GHRHR agonists and transplanted into the adrenal gland could
help treat diabetes. In cell culture, a potent GHRH analog increased the
viability and proliferation of rat islet cells compared with vehicle control.
The viability was further increased by coculture with adrenal cells. In a
mouse model of type 1 diabetes, transplantation of analog-preconditioned
islets into the adrenal gland rapidly decreased blood glucose levels compared
with transplantation into the standard kidney capsule. Next steps could
include optimizing the GHRH analogs for clinical use.
At least four companies have GHRHR agonists in development stages ranging
from preclinical to marketed for various indications.

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