Cafergot is indicated as therapy to abort or prevent vascular headache, e.g., migraine, migraine variants, or so-called "histaminic cephalalgia." Cafergot is a combination of 2 vasoconstrictors. It works by constricting blood vessels in the lining of the brain, which helps to decrease the pain from migraine headaches.

INSTRUCTIONS

Use Cafergot as directed by your doctor.

Cafergot may be taken with or without food.

Eating grapefruit or drinking grapefruit juice may affect the amount of Cafergot in your blood. Talk with your doctor before including grapefruit or grapefruit juice in your diet.

Cafergot is only to be used as needed for a migraine attack.

Take Cafergot at the first sign of a headache. If the initial dose does not relieve your headache, additional doses may be needed according to your doctor's instructions. Do not take a dose of Cafergot within 30 minutes of your last dose.

Do not take more than 6 tablets for a single migraine headache or more than 10 tablets during any 7-day period without first checking with your doctor.

If you miss a dose of Cafergot and you still have a headache, take it as soon as you remember. Do not take a dose of Cafergot within 30 minutes of your last dose. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Cafergot.

STORAGE

Store Cafergot at room temperature, between 59 and 86 degrees F (15 and 30 degrees C), in a tight, light-resistant container. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Cafergot out of the reach of children and away from pets.

Pressor agents (eg, norepinephrine) or sympathomimetics (eg, pseudoephedrine, albuterol) because risk of side effects, including severe high blood pressure, may be increased

Quinolones (eg, levofloxacin) because risk of side effects, such as nervousness, sleeplessness, and fast heartbeat, may be increased

Theophylline because actions and side effects may be increased by Cafergot.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Cafergot may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Do NOT exceed the recommended dose or take Cafergot for longer than prescribed without checking with your doctor. Cafergot is not for long-term daily use.

Use of nicotine may increase the risk of severe side effects with Cafergot. Talk to you doctor before using Cafergot if you smoke or use any other kind of nicotine.

Use Cafergot with extreme caution in children. Safety and effectiveness have not been confirmed.

Pregnancy and breast-feeding: Do not use Cafergot if you are pregnant. If you suspect that you could be pregnant, contact your doctor immediately. Cafergot should not be taken during labor and delivery. Cafergot is excreted in breast milk. If you are or will be breast-feeding while you are using Cafergot, check with your doctor or pharmacist to discuss the risks to your baby.

When used for long periods of time or at high doses, some people develop a need to continue taking Cafergot. This is known as dependence or addiction. It is important that you take Cafergot as instructed by your doctor. Cafergot is not for long-term daily use.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Nausea.

Seek medical attention right away if any of these severe side effects occur: