Pharmaceutical Sciences Research Institute (PSRI)

The Pharmaceutical Sciences Research Institute (PSRI) offers an alternative to traditional contract research organizations by providing research services in a highly cost effective and timely manner at the highest quality.

Services

The PSRI offers a broad range of drug discovery and development services focused on the non-clinical setting. Our expertise is centered in dose formulation and bioanalysis across a wide variety of standard and unconventional biomatrices.

Development and validation or transfer of analytical/bioanalytical methodologies in support of non-clinical dose range finding, PK, biodistribution (including CNS penetration), protein binding and various toxicology and safety assessment studies.

Formulation optimization

Non-clinical analysis of small molecules and peptides in formulations and biological tissues and fluids.

We offer comprehensive in-vitro metabolism studies including:

Metabolic stability

Metabolite identification

CYP450 phenotyping

Kinetics

Drug interactions

These studies can be customized by the client to support selection of the optimal drug candidate. Studies are conducted in all commercially available non-clinical sub-cellular fractions (e.g., microsomes for phase I and S9 fractions for phase II).