The man's friends administered first aid until NSW Ambulance paramedics arrived and he was taken to Nepean Hospital, where he later died.

Nine other festival-goers were reportedly taken to hospital.

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Defqon.1 Festival in action.

Photo: Facebook

"A man was located unconscious at the Defqon.1 festival at about 11.30 last night," a police spokesperson said. "He was taken to Nepean Hospital where he was pronounced deceased a short time later."

The death comes after James Munro, 23, died of a suspected ecstasy overdose at the Defqon.1 festival in 2013. Mr Munro told paramedics he had taken three pills, which he believed to be ecstasy, before he suffered a series of cardiac arrests.

Defqon.1 offered both overnight camping tickets and day passes and ran from 11am on Friday with the latest checkout at 1pm on Sunday.

The festival organiser, Q-dance Australia, said in a statement it was fully supporting the police investigation into the Albury man's death.

Revellers at a previous Defqon.1 dance music festival, where a man died on Saturday night.

Photo: Kevin Verkruijssen

"Our thoughts and prayers are with his family and friends," Q-dance Australia said.

"Everyone on our team is deeply shocked and affected by this tragic event."

Defqon.1 music festival at the Sydney International Regatta centre.

Photo: Jessica Aquilina

Investigators will prepare a report for the NSW Coroner.

Police arrested 60 people at the festival: 46 arrests were for drug offences, four of which were for drug supply, with two people allegedly caught with 46 pills, believed to be MDMA.

Others arrested were charged with public order and trespass offences.

In a related operation, a bus heading to the festival was stopped on Sherbrook Road at Hornsby by officers from Ku-ring-gai Local Area Command.

More than 30 passengers were searched with 14 allegedly found to be in possession of drugs including MDMA and cannabis.

Following this stop, a search warrant was executed at a home in Cecil Road, Hornsby.

Police allegedly found white powder suspected of being cocaine as well as pills, believed to be MDMA, steroids and $5800 in cash.