Arthur A. Simen MD, PhD

Biographical Info

Our goal is to understand the molecular mechanisms by which genetic, epigenetic, and environmental factors contribute to risk for complex psychiatric diseases and how risk is modified by development across the lifespan. We are committed to a truly translational approach involving preclinical models as well as human genetic studies. We use a number of molecular and computational methods toward these ends, including cell culture, mouse models, real-time PCR, DNA binding assays, confocal microscopy, genomic microarray and next-generation sequencing analysis, advanced statistical and computer programming methods, RNA interference, viral-mediated gene expression and gene knockdown, and epigenetic analysis. We welcome inquiries from students interested in working in this field.