Medical Xpress news tagged with:tumor metabolismhttp://medicalxpress.com/
en-usMedical Xpress internet news portal provides the latest news on science including: Physics, Nanotechnology, Life Sciences, Space Science, Earth Science, Environment, Health and Medicine.Targeting breast cancer metabolism to fight the diseaseHow does a cancer cell burn calories? New research from Thomas Jefferson University shows that breast cancer cells rely on a different process for turning fuel into energy than normal cells. The results were recently published in the Journal of Biological Chemistry.http://medicalxpress.com/news/2016-11-breast-cancer-metabolism-disease.html
CancerMon, 28 Nov 2016 02:17:15 ESTnews399521821Jet lag and obesity share similar pathways to liver cancerSince 1980, the incidence of hepatocellular carcinoma, the most common type of liver cancer, has nearly tripled, and obesity related liver disease is one of the driving forces behind the increasing number of cases. Baylor College of Medicine researchers are now examininng how other lifestyle factors may affect your health. Using mice, the scientists show that repeated jet lag increases both obesity related liver disease and the risk of liver cancer. The study appears November 23 in Cancer Cell.http://medicalxpress.com/news/2016-11-jet-lag-obesity-similar-pathways.html
CancerWed, 23 Nov 2016 12:39:29 ESTnews399127163Diabetes drug metformin corrects mitochondrial metabolism in familial cancer disorderIndividuals with Li-Fraumeni syndrome are at an increased risk for a number of cancers, including breast and bone cancer. Li-Fraumeni syndrome is an inherited cancer disorder caused by mutations in the tumor suppressing protein p53, which are also linked to increases mitochondrial metabolism. It is not clear whether targeting these metabolic changes can effectively reduce the risk of cancer associated with p53 mutations.http://medicalxpress.com/news/2016-11-diabetes-drug-metformin-mitochondrial-metabolism.html
CancerMon, 21 Nov 2016 17:03:19 ESTnews398970192Lung tumors hijack metabolic processes in the liver, study findsUniversity of California, Irvine scientists who study how circadian rhythms—our own body clocks—control liver function have discovered that cancerous lung tumors can hijack this process and profoundly alter metabolism.http://medicalxpress.com/news/2016-05-lung-tumors-hijack-metabolic-liver.html
Medical researchThu, 05 May 2016 12:00:11 ESTnews381642238How a metabolic pathway promotes breast cancer metastasisA metabolic pathway that is up-regulated in certain breast cancers promotes the disease's progression by activating a cell signaling protein called Arf6, according to a paper published in the Journal of Cell Biology. The study, "P53- and mevalonate pathway-driven malignancies require Arf6 for metastasis and drug resistance" by Ari Hashimoto and colleagues, has been published online ahead of print and suggests that statin-like drugs may be effective treatments for breast cancer patients whose tumors express high levels of Arf6 signaling proteins.http://medicalxpress.com/news/2016-04-metabolic-pathway-breast-cancer-metastasis.html
CancerWed, 06 Apr 2016 16:54:48 ESTnews379180476PGK1 protein promotes brain tumor formation and cancer metabolismPGK1, a glycolytic enzyme, has been found to play a role in coordinating cellular processes crucial to cancer metabolism and brain tumor formation, according to results published in today's online issue of Molecular Cell. The findings may lay the groundwork for improved approaches to diagnosis and treatment of glioblastoma and other cancers.http://medicalxpress.com/news/2016-03-pgk1-protein-brain-tumor-formation.html
CancerThu, 03 Mar 2016 14:20:03 ESTnews376236124Team develops approach for identifying processes that fuel tumor growth in lung cancer patientsScientists at the Children's Medical Center Research Institute at UT Southwestern (CRI) have pioneered a new method for conducting in-depth research on malignant tumors in patients, in the process discovering new complexities underlying cancer biology and overturning a nearly century-old perception about cancer metabolism.http://medicalxpress.com/news/2016-02-team-approach-fuel-tumor-growth.html
CancerThu, 04 Feb 2016 12:01:22 ESTnews373809669Study shows how certain drugs alter metabolism of pancreatic cancer cellsUT Southwestern Medical Center researchers have found that cancer drugs known as CDK4/6-inhibitors alter the metabolism of pancreatic cancer cells, revealing a biologic vulnerability that could be exploited for therapeutic gain. The findings were published today in Cell Reports.http://medicalxpress.com/news/2016-01-drugs-metabolism-pancreatic-cancer-cells.html
CancerThu, 21 Jan 2016 13:40:12 ESTnews372606001Research describes how glucose regulation enables malignant tumor growthA new study led by researchers at The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC - James) identifies a key pathway used by cancer cells to make the lipids by integrating oncogenic signaling, fuel availability and lipid synthesis to support cell division and rapid tumor growth.http://medicalxpress.com/news/2015-11-glucose-enables-malignant-tumor-growth.html
CancerMon, 09 Nov 2015 12:00:02 ESTnews366285397Can protein 14-3-3 sigma prevent or kill breast cancer tumors?Every parent knows the maxim "feed a cold, starve a fever." In cancer, however, exactly how to feed or starve a tumor has not been easy to determine.http://medicalxpress.com/news/2015-07-protein-sigma-breast-cancer.html
CancerThu, 16 Jul 2015 05:49:38 ESTnews356244568Early stage NSCLC patients with low tumor metabolic activity have longer survivalLow pre-surgery uptake of a labeled glucose analogue, a marker of metabolic activity, in the primary tumor of patients with stage I non-small cell lung cancer (NSCLC) is associated with increased overall survival and a longer time before tumor recurrence. Patients with high labeled glucose uptake may benefit from additional therapy following surgery.http://medicalxpress.com/news/2015-03-early-stage-nsclc-patients-tumor.html
CancerMon, 30 Mar 2015 11:21:33 ESTnews346933282Metabolic compensation underlies drug resistance in glioblastomaGliobststoma (GBM) is a highly aggressive brain tumor that is resistant to many conventional cancer therapies. The kinase mTOR induces pathways that are aberrantly activated in GBM. However, mTOR inhibitors have not shown much promise for treating GBM.http://medicalxpress.com/news/2015-03-metabolic-compensation-underlies-drug-resistance.html
CancerMon, 23 Mar 2015 17:01:00 ESTnews346348854Researchers uncover signal that switches cells to cancerous metabolismAbnormal metabolism within the cells is a distinctive characteristic of cancer, but until now, the mechanism that causes cells to undergo this metabolic shift remained unknown.http://medicalxpress.com/news/2015-02-uncover-cells-cancerous-metabolism.html
CancerWed, 11 Feb 2015 06:31:34 ESTnews342858684Researchers identify 'Achilles heel' in metabolic pathway that could lead to new cancer treatmentResearchers at UT Southwestern Medical Center have found an "Achilles heel" in a metabolic pathway crucial to stopping the growth of lung cancer cells.http://medicalxpress.com/news/2014-10-achilles-heel-metabolic-pathway-cancer.html
CancerTue, 07 Oct 2014 15:32:29 ESTnews331914737New cancer drug target involving lipid chemical messengersMore than half of human cancers have abnormally upregulated chemical signals related to lipid metabolism, yet how these signals are controlled during tumor formation is not fully understood.http://medicalxpress.com/news/2014-09-cancer-drug-involving-lipid-chemical.html
CancerSat, 20 Sep 2014 05:55:17 ESTnews330411306Researchers identify key mechanism in metabolic pathway that fuels cancersIn a breakthrough discovery at the Children's Medical Center Research Institute at UT Southwestern (CRI), a research team led by Ralph DeBerardinis, M.D., Ph.D., has taken a significant step in cracking the code of an atypical metabolic pathway that allows certain cancerous tumors to thrive, providing a possible roadmap for defeating such cancers.http://medicalxpress.com/news/2014-05-key-mechanism-metabolic-pathway-fuels.html
CancerThu, 22 May 2014 14:22:54 ESTnews319987359Key genetic mutations could be new hope for adrenocortical tumor patientsChinese researchers from Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, BGI, and other institutions have discovered that the activating hotspot L205R mutation in PRKACA gene was closely associated with adrenocortical tumors (ACTs), and the relationship of recurrently mutated DOT1L and CLASP2 with ACTs' other subtypes. The latest study published online in Science opens a new insight into diagnosis and treatment of Adrenal Cushing's syndrome.http://medicalxpress.com/news/2014-04-key-genetic-mutations-adrenocortical-tumor.html
CancerFri, 04 Apr 2014 10:09:56 ESTnews315824986New therapeutic approach to fight cancer discoveredResting cancer cells can be selectively destroyed by inhibiting their energy metabolism. This is the recent discovery by researchers at Charité Universitätsmedizin Berlin and the Max Delbrück Center for Molecular Medicine (MDC) in Berlin-Buch, together with other cooperation partners from Germany. The findings of their study have been published in the scientific journal Nature.http://medicalxpress.com/news/2013-09-therapeutic-approach-cancer.html
CancerWed, 04 Sep 2013 08:33:12 ESTnews297502374Researchers investigate 59 tumor cell linesIn what is the biggest study of its kind to date, researchers from Technische Universität München (TUM) have identified over 10,000 different proteins in cancer cells. "Nearly all anti-tumor drugs are targeted against cellular proteins," says Prof. Bernhard Küster, Head of the TUM Chair of Proteomics and Bioanalytics. "Identifying the proteome the protein portfolio of tumor cells increases our chances of finding new targets for drugs."http://medicalxpress.com/news/2013-08-tumor-cell-lines.html
CancerThu, 08 Aug 2013 12:00:01 ESTnews295178636Blocking key enzyme in cancer cells could lead to new therapyResearchers from the University of Illinois at Chicago College of Medicine have identified a characteristic unique to cancer cells in an animal model of cancer—and they believe it could be exploited as a target to develop new treatment strategies.http://medicalxpress.com/news/2013-08-blocking-key-enzyme-cancer-cells.html
CancerThu, 01 Aug 2013 15:03:58 ESTnews294588229Blocking sugar intake may reduce cancer risk or progression in obese and diabetic peopleBlocking dietary sugar and its activity in tumor cells may reduce cancer risk and progression, according to researchers from the Icahn School of Medicine. The study, conducted in fruit flies and published in the journal Cell, provides insight as to why metabolism-related diseases such as diabetes or obesity are associated with certain types of cancer, including pancreatic, breast, liver, and colon cancers.http://medicalxpress.com/news/2013-08-blocking-sugar-intake-cancer-obese.html
Medical researchThu, 01 Aug 2013 12:00:18 ESTnews294574490Molecular relative of p53 tumor suppressor protein also helps cancer cells thriveThey say you can pick your friends, but not your family. The same may hold true for related proteins. The protein TAp73 is a relative of the well-known, tumor-suppressor protein p53. It shares extensive common gene sequences with p53 and, as suggested by some previous studies, it may function similar to p53 to prevent tumor formation. However, unlike p53, which is the most commonly mutated gene in human tumors, TAp73 is rarely mutated, and instead is frequently overexpressed in a wide range of human tumors, including breast, colon, lung, stomach, ovarian, bladder, liver, neuroblastoma, glioma, and leukemias. In other words, cancer cells may have too many copies of the TAp73 gene.http://medicalxpress.com/news/2013-07-molecular-relative-p53-tumor-suppressor.html
CancerTue, 16 Jul 2013 15:35:22 ESTnews293207709Kidney cancer progression linked to shifts in tumor metabolismInvestigators in The Cancer Genome Atlas (TCGA) Research Network have uncovered a connection between how tumor cells use energy from metabolic processes and the aggressiveness of the most common form of kidney cancer, clear cell renal cell carcinoma (ccRCC). Their findings demonstrate that normal metabolism is altered in ccRCC tumor cells, and involves a shift from using one metabolic pathway to another. This change – termed a metabolic shift – correlates with tumor stage and severity in some cases.http://medicalxpress.com/news/2013-06-kidney-cancer-linked-shifts-tumor.html
CancerMon, 24 Jun 2013 15:13:08 ESTnews291305577Metabolic molecule drives growth of aggressive brain cancer(Medical Xpress)—A study led by researchers at The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) has identified an abnormal metabolic pathway that drives cancer-cell growth in a particular glioblastoma subtype. The finding might lead to new therapies for a subset of patients with glioblastoma, the most common and lethal form of brain cancer.http://medicalxpress.com/news/2013-06-metabolic-molecule-growth-aggressive-brain.html
CancerThu, 13 Jun 2013 16:40:42 ESTnews290360432Molecular imaging improves care for children with brain cancerA relatively new weapon in the fight against childhood brain cancer has emerged that improves upon standard magnetic resonance imaging (MRI) by providing information about tumor metabolism and extent of cancer in children diagnosed with glioma, a growth caused by the abnormal division of glial cells in the brain, say researchers at the Society of Nuclear Medicine and Molecular Imaging's 2013 Annual Meeting.http://medicalxpress.com/news/2013-06-molecular-imaging-children-brain-cancer.html
CancerTue, 11 Jun 2013 09:13:57 ESTnews290160829Breast cancer: PET and MR predict chemotherapy's ability to prolong lifeFor patients with advanced breast cancer, positron emission tomography (PET) and magnetic resonance (MR) imaging can improve quality of life and survival by providing physicians with information on the effectiveness of chemotherapy prior to surgery, say researchers presenting at the 2013 Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging.http://medicalxpress.com/news/2013-06-breast-cancer-pet-chemotherapy-ability.html
CancerTue, 11 Jun 2013 09:06:35 ESTnews290160389Tumors disable immune cells by using up sugarCancer cells' appetite for sugar may have serious consequences for immune cell function, researchers at Washington University School of Medicine in St. Louis have learned.http://medicalxpress.com/news/2013-06-tumors-disable-immune-cells-sugar.html
CancerThu, 06 Jun 2013 12:00:08 ESTnews289724488Oncogene mutation hijacks splicing process to promote growth and survivalAn international team of researchers – led by principal investigator Paul S. Mischel, MD, a member of the Ludwig Institute for Cancer Research and professor in the Department of Pathology at the University of California, San Diego School of Medicine – has found that a singular gene mutation helps brain cancer cells to not just survive, but grow tumors rapidly by altering the splicing of genes that control cellular metabolism.http://medicalxpress.com/news/2013-05-oncogene-mutation-hijacks-splicing-growth.html
CancerFri, 31 May 2013 21:54:30 ESTnews289256059Cancer cell metabolism killsAdenosine-5'-triphosphate (ATP) is the main energy source for all forms of work inside our cells. Scientists from the University of Helsinki, Finland, have found that even a short-term shortage of ATP supply can be fatal for cancer cells because activation of a mitochondria-addressed cell death pathway.http://medicalxpress.com/news/2013-04-cancer-cell-metabolism.html
CancerMon, 15 Apr 2013 15:00:04 ESTnews285240873Researchers identify critical metabolic alterations in triple-negative breast cancer cellsResearchers at Fox Chase Cancer Center have identified a host of small molecules critical to metabolism in cells of triple-negative breast cancer—one of the least understood groups of breast cancer. These molecules, called metabolites, include key players in energy regulation and lipid synthesis. They could help pave the way for helping researchers differentiate among different forms of the disease and ultimately point to new targets for treatment.http://medicalxpress.com/news/2013-04-critical-metabolic-triple-negative-breast-cancer.html
CancerTue, 09 Apr 2013 13:00:01 ESTnews284730706