Figure 6.

Reordered co-cluster matrix reveals co-clustering patterns. (a) Values in the co-cluster matrix range from 1 (light pink) to 9 (red) for nine clusterings
of the A. thaliana PPI network with 2402 proteins from
[31]. Pink regions represent item pairs that were placed in the same module by very few
clusterings while regions of more saturated red represent proteins that co-clustered
in most clusterings. Black indicates that the items never co-clustered. On the inset
matrix, the matrix items under the green square formed a core. A large blue square
overlay suggests that the core was tightly integrated into the rest of the network.
(b) Left: nodes that formed a core in (a) are colored green, the edges between the nodes
within the core are colored blue. The inset to the right shows an isolated view of
the core nodes (green), edges between core nodes (blue), and nodes one hop away from
the core nodes (gray). Green nodes share many edges with nodes outside of the core
which resulted in the core’s low cohesion.