The CFG is grateful to the following PIs for their contributions to this wiki page: Kurt Drickamer, Yvette van Kooyk

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The CFG is grateful to the following PIs for their contributions to this wiki page: Kurt Drickamer, Nicole Thielens, Yvette van Kooyk

Revision as of 17:51, 13 May 2010

The ficolins share a common organization and function with the collectins: serum mannose-binding and the pulmonary surfactant proteins C and D. All of these proteins are soluble mediators of innate immunity and consist of globular sugar-binding domains attached to collagenous stalks, which can invoke innate immune responses either through complement fixation or interaction with receptors on the surfaces of macrophages. Amongst these proteins, the ficolins have been most extensively investigated with CFG resources, while mannose-binding protein is the best characterized. The ficolins have fibrinogen-like sugar-binding domains, rather than C-type carbohydrate-recognition domains, but conceptually fall within the same group.

CFG Participating Investigators contributing to the understanding of this paradigm

Participating Investigators have generated and characterized knockout mice, defined the sugar-binding properties and undertaken structural analysis for members of this glycan-binding protein (GBP) group.

Non-PIs with who have used CFG resources to study ficolins include: David Stephens

Progress toward understanding this GBP paradigm

Carbohydrate ligands

Cellular expression

Structure

Biological roles of GBP-ligand interaction

CFG resources used in investigations

The best examples of CFG contributions to this paradigm are described below, with links to specific data sets. For a complete list of CFG data and resources relating to this paradigm, see the CFG database search results for ficolin and mannose-binding receptor.

Glycan profiling

Glycogene microarray

Knockout mouse lines

Glycan array

The binding specificities of several of the ficolins have been analyzed and other members of the group were screened on the CFG glycan array.