Chronic Granulomatous Disease (CGD)

Clinical Features and Laboratory Testing

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Relative Distribution of the PIDs

January 2010

The PIDs can be classified based on the component of the immune system that are affected - these include humoral or B cell defects, T cell or cellular defects, phagocytic defects and complement defects.
The humoral or antibody deficiencies account for the majority of the PIDs, ~65%, while "pure" cellular deficiencies account for only 5% of the total cases of PIDs. The combined cellular and humoral immune deficiencies account for another 15%, while the phagocytic and complement deficiencies account for the remaining 10% and 5% respectively.