Working with an international training expert, LaunchDSI updated Uganda’s ADS dispensing (sellers) and business (owners) curricula with new content and teaching methods. Additional content includes instructions on conducting rapid diagnostic tests for malaria and a suite of notifiable diseases that can be incorporated based on an individual country’s risk profile. In addition, our expert applied the best practices in adult learning by making the teaching methodology more interactive with role plays, exercises, and group discussions. We recommend that countries looking to launch accredited drug seller initiatives use these curricula to adapt for their own contexts.