1. Chrono Trigger (Two games count as a Franchise right?)
2. Metal Gear Solid (Splinter Cell is more hardcore, but MGS is just more fun)
3. Final Fantasy (IV, V, VI, VII and Tactics rocked.)
4. Metroid (Probably the most reliable)
5. Sonice the Hedgehog (Man, Sega could do no wrong with Sonic on the Genesis)