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Title:

Pharmaceutical formulation

Abstract:

The instant invention provides a pharmaceutical composition comprised of a cholesterol absorption inhibitor and an HMG-CoA reductase inhibitor, one or more anti-oxidants, microcrystalline cellulose, hydroxypropyl methylcellulose, magnesium stearate and lactose. The composition need not contain ascorbic acid in order to obtain desirable stability.

Inventor(s):

Cho; Wing-Kee Philip (Princeton, NJ)

Assignee:

Schering Corporation (Kenilworth, NJ)

Filing Date:

May 26, 2009

Application Number:

12/472,021

Claims:

1. A pharmaceutical composition comprising: (a) from 1% to 20% by weight of a cholesterol absorption inhibitor; (b) from 1% to 80% by weight of at least one HMG-CoA reductase inhibitor; (c) from 0.005% to 10% by weight of ascorbic acid; (d) croscarmellose sodium; and (e) povidone.

2. The pharmaceutical composition according to claim 1, wherein the cholesterol absorption inhibitor is ezetimibe.

3. The pharmaceutical composition according to claim 1, wherein the HMG-Co-A reductase inhibitor is simvastatin or atorvastatin.

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