Anxiety and depression involve deregulation of the serotonin (5-HT) system, and corticotrophin-releasing factor (CRF) release inhibits 5-HT neuronal activity in the dorsal raphe {1}. Here, the authors found that this effect of CRF might primarily be due to an indirect effect via stimulation of inhibitory GABAergic synaptic transmission. This information could be useful when creating different treatments for anxiety and depression.

Anxiety...

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