Dietary-Induced Obese Animal

Creative Animodel is the leading services provider for obesity mechanism study and anti-obesity drug development. We have extensive experience on obesity study based on Dietary-induced obese (DIO) mice and rats and high fat diet mice/rats. We will assist you on each step of your study of obesity.

Dietary-induced obese (DIO) mice and rats are well-established animal models of obesity. The primary cause of obesity is excessive caloric intake with too little exercise. Dietary-induced obesity (DIO) in mice and rats usually involves a high-fat, high-carbohydrate diet and is translatable to the human population. Furthermore, animals with all genetic background could be the model for DIO animal.

✓ An excellent polygenic screen for investigating the efficacy and tolerability of drugs before chronic feeding studies in dietary-induced obese rats/mice.
✓ It does not include a lengthy induction of obesity period therefore animals are readily available.
✓ Pharmacological model relevant to the main classes of approved anti-diabetic compounds

Acute, sub-chronic and chronic feeding studies can be performed in DIO mice/rats and high fat diet mice/rats, and drugs can be given by a variety of routes. Body weights and daily food and water intakes are recorded routinely. Studies in dietary-induced obese rats and mice can include a number of other optional extras to investigate the effects of drugs on obesity-related comorbidities or to investigate the mechanisms underlying the weight-loss, including but not limited to:

With Creative Animodel, all studies in dietary-induced obese mice/rats and high fat diet mice/rats can be customized to meet your specific requirements and include advice on experimental design, statistical analysis by a qualified statistician, fully audited data pack and written reports to regulatory standards if required.