Zidovudine (Azidothymidine, AZT) is a nucleoside analog reverse-transcriptase inhibitor (NRTI), a type of antiretroviral drug used for the treatment of HIV/AIDS infection.;IC50 value:;Target: NRTI; reverse-transcriptaseAZT is a thymidine analogue. AZT works by selectively inhibiting HIV's reverse transcriptase, the enzyme that the virus uses to make a DNA copy of its RNA. Reverse transcription is necessary for production of HIV's double-stranded DNA, which would be subsequently integrated into the genetic material of the infected cell (where it is called a provirus). ;The azido group increases the lipophilic nature of AZT, allowing it to cross infected cell membranes easily by diffusion and thereby also to cross the blood?brain barrier. Cellular enzymes convert AZT into the effective 5'-triphosphate form. Studies have proven that the termination of HIV's forming DNA chains is the specific factor in the inhibitory effect. MedChem ExpressHY-17413