Application Information: CD71 antibody [236-15375(MEM-75)]

Specifications: CD71 antibody [236-15375(MEM-75)]

Full Name

transferrin receptor (p90, CD71)

Product Description

Mouse monoclonal antibody [236-15375(MEM-75)] to CD71

Background

Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site.

Synonyms

CD71, TFR, TFR1, TRFR

Cellular Localization

Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Specificity

CD71, Transferrin Receptor

Host

Mouse

Clonality

Monoclonal

Clone Name

236-15375(MEM-75)

Target

CD71

Isotype

IgG1

Species Reactivity

Human

Storage Conditions: CD71 antibody [236-15375(MEM-75)]

Storage Buffer

Tris Buffered Saline, pH 8.0 and 15 mM Sodium Azide

Storage Instruction

Upon receipt, store at –20°C. Avoid multiple freeze/thaw cycles.

Notes

For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.