Applying physical science techniques and CERN technology to an unsolved problem in radiation treatment for cancer: the multidisciplinary 'VoxTox' research programme.

Burnet, NG and Scaife, JE and Romanchikova, M and Thomas, SJ and Bates, AM and Wong, E and Noble, DJ and Shelley, LE and Bond, SJ and Forman, JR and Hoole, AC and Barnett, GC and Brochu, FM and Simmons, MP and Jena, R and Harrison, K and Yeap, PL and Drew, A and Silvester, E and Elwood, P and Pullen, H and Sultana, A and Seah, SY and Wilson, MZ and Russell, SG and Benson, RJ and Rimmer, YL and Jefferies, SJ and Taku, N and Gurnell, M and Powlson, AS and Schönlieb, C-B and Cai, X and Sutcliffe, MP and Parker, MA (2017) Applying physical science techniques and CERN technology to an unsolved problem in radiation treatment for cancer: the multidisciplinary 'VoxTox' research programme. CERN Ideasq J Exp Innov, 1. pp. 3-12.

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Abstract

The VoxTox research programme has applied expertise from the physical sciences to the problem of radiotherapy toxicity, bringing together expertise from engineering, mathematics, high energy physics (including the Large Hadron Collider), medical physics and radiation oncology. In our initial cohort of 109 men treated with curative radiotherapy for prostate cancer, daily image guidance computed tomography (CT) scans have been used to calculate delivered dose to the rectum, as distinct from planned dose, using an automated approach. Clinical toxicity data have been collected, allowing us to address the hypothesis that delivered dose provides a better predictor of toxicity than planned dose.