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The original queen of comedy, Lucille Ball, whose antics on her long-running sitcom, ‘I Love Lucy,’ paved the way for future comediennes

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Wendi McLendon-Covey made us laugh on ‘Reno 911!’ and ‘Rules of Engagement’ before winning our hearts as the world’s best overbearing ‘Smother,’ Beverly Goldberg, on ‘The Goldbergs’

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Comedy queen Tina Fey starred on ‘Saturday Night Live’ — and became the show’s first female head writer — before bringing her genius to the Emmy Award-winning comedy, ‘30 Rock’

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Melissa McCarthy graced the small screen on ‘Gilmore Girls,’ ‘Samantha Who?’ and most recently, ‘Mike & Molly.’ On the big screen, Melissa had audiences screaming with laughter as rogue bridesmaid Megan in “Bridesmaids”

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Christina Applegate made us laugh on ‘Married with Children,’ before moving on to ‘Samantha Who?’ Now, this bubbly blonde has joined forces with Maya Rudolph for NBC’s ‘Up All Night’

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Jane Krakowski cracked us up as Jenna on ‘30 Rock’ before playing Jaqueline Vorhees in Netflix’s ‘Unbreakable Kimmy Schmidt’

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From her days on ‘The Mary Tyler Moore Show,’ to ‘The Carol Burnett Show’ and her legendary years on ‘The Golden Girls,’ Betty White has kept us in stitches for decades! The beloved dynamo continues the laughter on TV Land’s ‘Hot in Cleveland’

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Courteney Cox brought the laughs for years as Monica Geller on ‘Friends,’ and now, she keeps us in stitches on her ABC hit, ‘Cougar Town’

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Kristen Wiig’s brave comedy on ‘Saturday Night Live’ earned the actress roles in big screen features such as ‘Knocked Up,’ ‘Adventureland,’ ‘Whip It’ and the starring role in ‘Bridesmaids,’ which she co-wrote

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Who could forget self-proclaimed ‘original domestic goddess’ Roseanne Barr?! After dominating the small screen for years on ‘Roseanne,’ the actress is set to star in an upcoming comedy, ‘Downwardly Mobile’

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Amy Poehler cracked us up on ‘Saturday Night Live’ before starring in NBC’s hit comedy, ‘Parks and Recreation’

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Lisa Kudrow brought the funny as Phoebe on ‘Friends’ before moving on to ‘The Comeback’ and her latest TV gig, ‘Web Therapy’

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Katey Sagal played tough-talking Bundy family matriarch Peggy Bundy for 10 years on ‘Marriedâ€¦ with Children’

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Olivia Munn parlayed her co-hosting gig on G4’s ‘Attack of the Show’ into a starring role on NBC’s hilarious, yet short-lived sitcom, ‘Perfect Couples,’ along with correspondent duties on ‘The Daily Show’

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Julia Louis-Dreyfus got her start on ‘Saturday Night Live’ before moving on to ‘Seinfeld,’ ‘Curb Your Enthusiasm’ and ‘The New Adventures of Old Christine’

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Jane Lynch won an Emmy for her recurring guest role on ‘Two and a Half Men’ before hilariously tormenting the halls of William McKinley High as Sue Sylvester on ‘Glee’

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After starring in notable films like ‘The Goonies’ and ‘Parenthood,’ Martha Plimpton is keeping us laughing as ‘Raising Hope’s’ Virginia Chance

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Elizabeth Banks burst onto the scene in 2001’s ‘Wet Hot American Summer’ and graced audiences with her hilarity in a recurring role on ‘30 Rock’