Abstract:Autologous fat grafting (AFG) or lipofilling has achieved satisfactory clinical results in improving the asymmetryafterbreast cancer surgery, and it is becoming a commonorthopedictechnique. However, there is debate regarding theoncologicalsafety and risks of this procedure in breast cancer patients.Several experimental studies have shown that adiposecells release regulatory factors through endocrine, paracrine andautocrine pathways to stimulate the growth of breast cancercells.However,the existing clinical evidence does notclarify the relationship between AFG and cancer recurrence.Thispaper,through systematic review of experimental studies and clinical data,discusses the oncological safety of fat transplantationin breast cancer patients,and makesrecommendations for patients with the intention of lipofilling.