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ABSTRACT
Mangoes (Mangifera indica L.) are one of the most important tropical foods. The seed is one of the main by-products of mango processing. Therefore, it is important to find an economically viable use for this waste (e.g., as a food additive or supplement with high nutraceutical value). We investigated the anti-obesity effects of man- go seed kernel extract with hot water (MSKE-W) in 3T3-L1 adipocytes and in a high fat diet (HFD)-induced obesity rat model. MSKE-W cau- sed a significant decrease in the activity of gly- cerol 2-phosphate dehydrogenase in 3T3-L1 adi- pocytes without eliciting cell cytotoxicity and inhibited cellular lipid accumulation through down-regulation of transcription factors such as PPARγ and C/EBPα. In the animal model, rats fed an HFD containing 1% MSKE-W gained less weight than rats fed an HFD alone. The visceral fat mass in rats fed an HFD containing 1% MSKE-W tended to be lower than that in rats fed an HFD alone. Furthermore, histological exami- nation of rat livers from an HFD showed steato- hepatitis. However, rats on an HFD containning 1% MSKE-W showed no histopathological chan- ges in liver tissue. Our results indicate that MSKE-W influences anti-obesity effects, both in vitro and in vivo, and suggest that MSKE-W provides a novel preventive potential against obesity.
Proliferator-Activated Receptor γ (PPARγ); High Fat Diet-Induced Obesity Rat Model; 3T3-L1 Adipocytes