detect the outliers from 'time-serial multivariate' data within ArcGIS?

Have you experienced 'directly' detecting the outliers from 'time-serial multivariate' data (saying, 3-5 variables) within ArcGIS 10.4 /10.3.1? Or, do you have any effective approach to 'seamlessly' make use of the package ‘scikit-learn’ in ArcGIS for the above purpose?