Historical Background

RUNX was discovered in the early 1990s by several independent studies. The first RUNX family member to be cloned, Drosophila runt, encodes nuclear protein with no known function and has roles in segmentation, sex determination, and neurogenesis (Kania et al. 1990). Shortly after that, the human RUNX1was sequenced as part of the t(8;21) (q22;q22) chromosomal translocation, a common recurrent...