W42Industrial Biotechnology

W42Industrial Biotechnology GmbHstarts technology development for new Biorefinery concept.

At the 12 th of October 2016 the KOM for the EU-project Zelcor will take place in Versailles. Zelcor has as its overall goal to demonstrate the feasibility of transforming recalcitrant by-products considered as waste, namely lignin- and humins-rich streams, into high added value materials, including functional biopolymers, lignin oligomers and phenolic monomers. The specific driving idea is to combine chemical and enzymatic catalyses with microbial bioconversion to develop an integrated flexible biorefinery system for the conversion of these heterogeneous and variable by-products.

2016 February

W42Industrial Biotechnology GmbHhas successfully developed an industrial strain for the production of recombinant human hormone Prolactin.

The production of human prolactin in the methylotrophic yeast Pichia pastoris on high level was established by rational strain development using the advanced ‘in-house’ tool-box. Actually the protocol for purification of prolactin is under development. Highly purified prolactin will be available for our customers soon.

2015 October – Actinomycin V

W42Industrial Biotechnology GmbHhas implemented the technology for production of the highly toxic natural compound Actinomycin V (X2). The cultivation of the unique producer strain and the high efficient DSP (extraction/chromatography) is basis for the production of pure compound (>90% by HPLC). This drug is one favorite candidate for advanced therapy of cancer by “antibody drug conjugate” strategy.

2015 May – Vaccine development for Aquaculture

W42Industrial Biotechnology GmbHsuccessful in vaccine development

In 2013 the EU-project TargetFish (www.targetfish.eu) was started dealing with the development of new and powerful targeted vaccination strategy against bacterial and viral fish-pathogens. The high-efficient protein expression technology of W42 was used for the production of selected virus like particles (VLP) and membrane attached glycoproteins using a unique surface display approach. Candidates of both pathogen specific class of proteins are actually proved for vaccination of different fish species. First promising results will now enable the development of efficient, high-specific and economical vaccines.

In April 2015 a second project to support the prospective fish-farming industry was started by the EU. ParaFishControl (www.parafishcontrol.eu) will be focused on eucaryotic fish-pathogens, and the expression technology of W42 will be again a central part of the project. The international consortium consisting of 18 public research groups, 3 industrial partners, 7 SME and 2 non-profit foundations will be supported by the EU with 7.8 million €.