Extensive forested wetlands are found in the southeastern United States. These wetlands provide important ecosystem functions and services such as timber supply, water quality improvement, recreation, and wildlife habitat. However, they are at risk due to ongoing climate and land use change. Our study examined 5 typical wetlands across the southeast including cypress swamps, pine flatwoods, Carolina bays, drained pocosins, and natural bottomland hardwoods. We developed a series empirical predictive models to relate observed water level fluctuations to historic climate, then we applied the models to project into the future using multiple climate change scenarios. We show that compared to the historical period, all five wetlands are projected to become drier, and some may even disappear under severe climate change scenarios due to projected ecohydrological changes. This information is helpful for land managers to develop climate change mitigation and adaptation methods to protect and manage these important wetlands.