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Access to the article is free, however registration and sign-in are required. Our view of the cell's cytoplasm has come a long way. Once considered static "free space" between the nucleus and plasma membrane, it is now known to be a highly dynamic cellular entity with limited space for free movement. It is a dense, organized, tightly regulated, and dynamic network of organelles, cytoskeleton (including microtubules, actin, and intermediate filaments), and vesicles that shuttle between organelles. Yet, some pathogenic bacteria move quite efficiently through this cytoplasmic jungle, invading one cell to the next. Yoshida et al. report that Shigella, the bacteria responsible for dysentary, hacks its way through microtubules by wielding a tubulin- specific protease.

Access to the article is free, however registration and sign-in are required. Our view of the cell's cytoplasm has come a long way. Once considered static "free space" between the nucleus and plasma membrane, it is now known to be a highly dynamic cellular entity with limited space for free movement. It is a dense, organized, tightly regulated, and dynamic network of organelles, cytoskeleton (including microtubules, actin, and intermediate filaments), and vesicles that shuttle between organelles. Yet, some pathogenic bacteria move quite efficiently through this cytoplasmic jungle, invading one cell to the next. Yoshida et al. report that Shigella, the bacteria responsible for dysentary, hacks its way through microtubules by wielding a tubulin- specific protease.