Featured Research

from universities, journals, and other organizations

Gluten-free, casein-free diet may help some children with autism, research suggests

Date:

February 29, 2012

Source:

Penn State

Summary:

A gluten-free, casein-free diet may lead to improvements in behavior and physiological symptoms in some children diagnosed with an autism spectrum disorder (ASD), according to researchers. The research is the first to use survey data from parents to document the effectiveness of a gluten-free, casein-free diet on children with ASD.

Share This

A gluten-free, casein-free diet may lead to improvements in behavior and physiological symptoms in some children diagnosed with an autism spectrum disorder (ASD), according to researchers at Penn State. The research is the first to use survey data from parents to document the effectiveness of a gluten-free, casein-free diet on children with ASD.

Related Articles

"Research has shown that children with ASD commonly have GI [gastrointestinal] symptoms," said Christine Pennesi, medical student at Penn State College of Medicine. "Notably, a greater proportion of our study population reported GI and allergy symptoms than what is seen in the general pediatric population. Some experts have suggested that gluten- and casein-derived peptides cause an immune response in children with ASD, and others have proposed that the peptides could trigger GI symptoms and behavioral problems."

The team -- which included Laura Cousino Klein, associate professor of biobehavioral health and human development and family studies -- asked 387 parents or primary caregivers of children with ASD to complete a 90-item online survey about their children's GI symptoms, food allergy diagnoses, and suspected food sensitivities, as well as their children's degree of adherence to a gluten-free, casein-free diet. The team's results appeared online this month in the journal Nutritional Neuroscience.

Pennesi and Klein and their team found that a gluten-free, casein-free diet was more effective in improving ASD behaviors, physiological symptoms and social behaviors for those children with GI symptoms and with allergy symptoms compared to those without these symptoms. Specifically, parents noted improved GI symptoms in their children as well as increases in their children's social behaviors, such as language production, eye contact, engagement, attention span, requesting behavior and social responsiveness, when they strictly followed a gluten-free, casein-free diet.

According to Klein, autism may be more than a neurological disease -- it may involve the GI tract and the immune system.

"There are strong connections between the immune system and the brain, which are mediated through multiple physiological symptoms," Klein said. "A majority of the pain receptors in the body are located in the gut, so by adhering to a gluten-free, casein-free diet, you're reducing inflammation and discomfort that may alter brain processing, making the body more receptive to ASD therapies."

The team found that parents who eliminated all gluten and casein from their children's diets reported that a greater number of their children's ASD behaviors, physiological symptoms and social behaviors improved after starting the diet compared to children whose parents did not eliminate all gluten and casein. The team also found that parents who implemented the diet for six months or less reported that the diet was less effective in reducing their child's ASD behaviors.

According to the researchers, some of the parents who filled out the surveys had eliminated only gluten or only casein from their children's diets, but survey results suggested that parents who completely eliminated both gluten and casein from their child's diet reported the most benefit.

"While more rigorous research is needed, our findings suggest that a gluten-free, casein-free diet might be beneficial for some children on the autism spectrum," Pennesi said. "It is also possible that there are other proteins, such as soy, that are problematic for these children."

The reason Klein and Pennesi examined gluten and casein is because they are two of the most common "diet offenders."

"Gluten and casein seem to be the most immunoreactive," Klein said. "A child's skin and blood tests for gluten and casein allergies can be negative, but the child still can have a localized immune response in the gut that can lead to behavioral and psychological symptoms. When you add that in with autism you can get an exacerbation of effects."

Klein's advice to parents of children with ASD?

"If parents are going to try a gluten-free, casein-free diet with their children, they really need to stick to it in order to receive the possible benefits," she said. "It might give parents an opportunity to talk with their physicians about starting a gluten-free, casein-free diet with their children with ASD."

Story Source:

The above story is based on materials provided by Penn State. Note: Materials may be edited for content and length.

Penn State. "Gluten-free, casein-free diet may help some children with autism, research suggests." ScienceDaily. ScienceDaily, 29 February 2012. <www.sciencedaily.com/releases/2012/02/120229105128.htm>.

Penn State. (2012, February 29). Gluten-free, casein-free diet may help some children with autism, research suggests. ScienceDaily. Retrieved March 31, 2015 from www.sciencedaily.com/releases/2012/02/120229105128.htm

Penn State. "Gluten-free, casein-free diet may help some children with autism, research suggests." ScienceDaily. www.sciencedaily.com/releases/2012/02/120229105128.htm (accessed March 31, 2015).

Mar. 31, 2015 — A criminologist finds that solitary confinement does not deter inmates from committing further violence in prison. The prisoners in the study who received solitary confinement were no more -- or less ... full story

Mar. 31, 2015 — Alcoholism takes a toll on every aspect of a person's life, including skin problems. Now, a new research report helps explain why this happens and what might be done to address it. "The clinical ... full story

Mar. 31, 2015 — Human language likely developed quite rapidly into a sophisticated system, a linguist contends. Instead of mumbles and grunts, people deployed syntax and structures resembling the ones we use today, ... full story

Mar. 31, 2015 — Coronary heart disease and stroke, two of the leading causes of death in the United States, are diseases associated with heightened platelet reactivity. A new study in humans suggests an underlying ... full story

Mar. 31, 2015 — A new study had researchers seeking answers to why the therapeutic benefit afforded by SSRIs was so limited in children and teenagers. If researchers can uncover the biological mechanisms preventing ... full story

Mar. 31, 2015 — During prenatal development, the brains of most animals, including humans, develop specifically male or female characteristics. But scientists have known little about the details of how this ... full story

Mar. 31, 2015 — A history of depression may put women at risk for developing diabetes during pregnancy, according to research. This study also pointed to how common depression is during pregnancy and the need for ... full story

Mar. 31, 2015 — Women who are abused by their partner or ex-partner are much less likely to use contraception; this exposes them to sexually transmitted diseases and leads to more frequent unintended pregnancies and ... full story

Mar. 31, 2015 — Video games not only sharpen the visual processing skills of frequent players, they might also improve the brain's ability to learn those skills, according to a new study. Gamers showed faster ... full story

Featured Videos

AAA: Distracted Driving a Serious Teen Problem

AP (Mar. 25, 2015) — While distracted driving is not a new problem for teens, new research from the AAA Foundation for Traffic Safety says it&apos;s much more serious than previously thought. (March 25)
Video provided by AP

Many Don't Know They Have Alzheimer's, But Their Doctors Do

Newsy (Mar. 24, 2015) — According to a new study by the Alzheimer&apos;s Association, more than half of those who have the degenerative brain disease aren&apos;t told by their doctors.
Video provided by Newsy

A Quick 45-Minute Nap Can Improve Your Memory

Newsy (Mar. 23, 2015) — Researchers found those who napped for 45 minutes to an hour before being tested on information recalled it five times better than those who didn&apos;t.
Video provided by Newsy

Related Stories

June 16, 2014 — Individuals with celiac disease often experience 'brain fog' in addition to intestinal problems, but a new study shows that adhering to a gluten-free diet can lead to improvements in ... full story

June 28, 2012 — Two nutrition experts say going gluten-free may be a good choice for some individuals, but that just because a product's label says it's gluten-free doesn't means that it's ... full story

Dec. 21, 2011 — Beer tested in a new study, including some brands labeled "low-gluten," contains levels of hordein, the form of gluten present in barley, that could cause symptoms in patients with celiac ... full story

May 19, 2010 — A popular belief that specific dietary changes can improve the symptoms of children with autism was not supported by a tightly controlled study, which found that eliminating gluten and casein from ... full story

May 2, 2010 — Complementary and alternative medicine (CAM) is becoming a popular treatment for a variety of conditions, with national data showing it is used by about 12 percent of children. New research shows ... full story

ScienceDaily features breaking news and videos about the latest discoveries in health, technology, the environment, and more -- from major news services and leading universities, scientific journals, and research organizations.