Roker recently confessed to “Dateline” that he once “pooped” his pants at the White House, and news of the accident, ahem, exploded online.

Handler responded with a zinger on her E! show, “Chelsea Lately,” saying, “This isn’t the first time a ‘Today’ show cast member was in the news about this sensitive subject. For years it was common knowledge that Matt Lauer spent every morning [s - - ting] all over Ann Curry.”

But Handler’s bosses — Comcast owns NBC and E! — were apparently not as amused as her audience.

“Chelsea’s writers were warned to lay off Matt,” says a source close to the show. “They don’t want them making more fun of Matt and the Ann Curry situation right now.” Lauer’s been a public target since Curry was canned as co-host of “Today” and replaced by Savannah Guthrie.

An E! rep said the story was "absolutely false, and no such request was made.”