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Publications23

Probability in transcriptional regulation and its implications for leukocyte differentiation and inducible gene expression

D A HumeDepartments of Biochemistry and Microbiology Parasitology and the Centre for Molecular and Cellular Biology, University of Queensland, Queensland, AustraliaBlood 96:2323-8. 2000

..The probabilistic nature of transcriptional regulation provides one explanation for stochastic phenomena, such as stem cell lineage commitment, and monoallelic expression of inducible genes, such as lymphokines and cytokines...

Regulation of the murine TRACP gene promoter

A I CassadyInstitute for Molecular Biosciences and School of Molecular and Microbial Sciences, The University of Queensland, Brisbane, Queensland, AustraliaJ Bone Miner Res 18:1901-4. 2003

..This directly links two controlling factors of osteoclast differentiation to the expression of an effector of cell function...

..These mice provide evidence that inclusion of an irrelevant enhancer does not necessarily override a tissue-specific promoter...

Activation of macrophages to express cytocidal activity correlates with inhibition of their responsiveness to macrophage colony-stimulating factor (CSF-1): involvement of a pertussis toxin-sensitive reaction

..The ability of pertussis toxin to both inhibit CSF-1-induced proliferation and trigger cytotoxicity in macrophages suggests the involvement of a regulatory GTP-binding protein (G protein) in both processes...

..The macrophage response to DNA generates cytokines favouring the development of Th1-type immunity, and active oligonucleotides now show promise as Th1-promoting adjuvants and as allergy treatments...

Induction of Nramp2 in activated mouse macrophages is dissociated from regulation of the Nramp1, classical inflammatory genes, and genes involved in iron metabolism

S L WardropInstitute of Molecular Biosciences and ARC Special Research Centre for Functional and Applied Genomics, University of Queensland, Brisbane, AustraliaJ Leukoc Biol 71:99-106. 2002

..We suggest that Nramp2 is regulated independently of known iron-responsive genes in macrophages, and its function in host defense is unrelated to Nramp1...

..The long-term survival of these animals should provide an excellent model with which to study cystic fibrosis, and they illustrate the value of mouse models carrying relevant mutations for examining genotype-phenotype correlations...

..This review examines the evidence that the op/op mouse is completely CSF-1 deficient and considers the possibility that alternative splicing within the CSF-1 gene might bypass the mutation, yielding an incompletely penetrant phenotype...

Isolation and characterization of the genes encoding mouse and human type-5 acid phosphatase

A I CassadyCentre for Molecular Biology and Biotechnology, University of Queensland, AustraliaGene 130:201-7. 1993

..These differences may result in distinctive regulation of T5AP and Utf expression...