The SLiMEnrich App allows users to predict Domain-Motif Interactions (DMIs) from Protein-Protein Interaction data (PPI) and to estimate the background distribution of expected DMI by chance through a randomisation approach. The walkthrough has more details.

SLiMEnrich can be used to:

Estimate the enrichment of SLiM-mediated DMI in a given PPI dataset.

Generate predictions for DMI-mediated from a PPI dataset. Predictions are based on known SLiM-Domain interactions.

Estimate the False Positive Rate of those DMI predictions.

With a bit of imagination, SLiMEnrich can be adapted to generate and assess predictions for other kinds of interactions. See docs for details.