San Francisco 49ers head coach Kyle Shanahan, right, talks with head linesman Hugo Cruz (94) during the second half of an NFL football game between the 49ers and the Carolina Panthers in Santa Clara, Calif., Sunday, Sept. 10, 2017. (AP Photo/Tony Avelar)

Carolina Panthers quarterback Cam Newton (1) celebrates after Jonathan Stewart scored a touchdown against the San Francisco 49ers during the second half of an NFL football game in Santa Clara, Calif., Sunday, Sept. 10, 2017. (AP Photo/Marcio Jose Sanchez)

The Associated Press

San Francisco 49ers linebacker Reuben Foster (56) is tended to by a trainer as teammates and Carolina Panthers quarterback Cam Newton (1) watch during the first half of an NFL football game in Santa Clara, Calif., Sunday, Sept. 10, 2017. (AP Photo/Marcio Jose Sanchez)

The Associated Press

San Francisco 49ers quarterback Brian Hoyer (2) passes against the Carolina Panthers during the first half of an NFL football game in Santa Clara, Calif., Sunday, Sept. 10, 2017. (AP Photo/Tony Avelar)

The Associated Press

San Francisco 49ers head coach Kyle Shanahan watches the second half of an NFL football game against the Carolina Panthers in Santa Clara, Calif., Sunday, Sept. 10, 2017. (AP Photo/Tony Avelar)

San Francisco 49ers head coach Kyle Shanahan, right, talks with head linesman Hugo Cruz (94) during the second half of an NFL football game between the 49ers and the Carolina Panthers in Santa Clara, Calif., Sunday, Sept. 10, 2017. (AP Photo/Tony Avelar)

Carolina Panthers quarterback Cam Newton (1) celebrates after Jonathan Stewart scored a touchdown against the San Francisco 49ers during the second half of an NFL football game in Santa Clara, Calif., Sunday, Sept. 10, 2017. (AP Photo/Marcio Jose Sanchez)

The Associated Press

San Francisco 49ers linebacker Reuben Foster (56) is tended to by a trainer as teammates and Carolina Panthers quarterback Cam Newton (1) watch during the first half of an NFL football game in Santa Clara, Calif., Sunday, Sept. 10, 2017. (AP Photo/Marcio Jose Sanchez)

The Associated Press

San Francisco 49ers quarterback Brian Hoyer (2) passes against the Carolina Panthers during the first half of an NFL football game in Santa Clara, Calif., Sunday, Sept. 10, 2017. (AP Photo/Tony Avelar)

The Associated Press

San Francisco 49ers head coach Kyle Shanahan watches the second half of an NFL football game against the Carolina Panthers in Santa Clara, Calif., Sunday, Sept. 10, 2017. (AP Photo/Tony Avelar)

The Associated Press

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SANTA CLARA, Calif. — Cam Newton threw a pair of touchdown passes following San Francisco turnovers and the Carolina defense shut down Kyle Shanahan's offense in his coaching debut as the Panthers beat the 49ers 23-3 Sunday.