Specific Goal: Understanding how ectopic expression of the transcription factor, TAL-1 (see Fig. 1), contributes to leukemogenesis. Through ill-defined mechanisms, TAL-1 seems to play a significant role in the progression of T-cell acute lymphoblastic leukemia. It is thought that important cellular processes such as cell cycle control, cell signaling and apoptosis (see Fig. 2) are influenced by this mis-expressed protein. Through investigating

Image from Cell Signaling Technology website

potential targets of TAL-1, it is hoped that a better picture of how TAL-1 influences apoptotic resistance and cell survival will be realized. In the end, this type of research will hopefully guide the future development of better, more targeted therapies to treat T-ALL at the molecular level.