Abstract

Eosinophilic granuloma of bone as a clinical entity was first delineated by Lichtenstein and Jaffe1 in 1940. Their report was based on the case history of a four year old girl with a lesion of the femur, which was considered to represent a previously undescribed granuloma of bone containing many eosinophils. Otani and Erlich2 described the same type of granuloma of bone and stated that its roentgenologic appearance simulated that of primary neoplasm. Farber3 postulated that eosinophilic granuloma of bone, Hand-Schüller-Christian disease, and Letterer-Siwe disease are variations of the same entity. This was supported by Green and Farber's4 study of