Tsitsipas, featuring in his first tournament since that sensational run at Melbourne Park, was beaten 6-3 7-6 (7-5) as Monfils booked a meeting with Daniil Medvedev.

Monfils took the first thanks to breaks at either end of the set and although second seed Tsitsipas had a 5-4 lead in the second-set breaker with two serves to come, his opponent reeled off three straight points to secure progress.