"For single point thermocouple measurements with PG, coil temperatures ranged from 322 ‒ 1008°C, 145 ‒ 334°C, and 110 ‒ 185°C under dry, wet-through-wick, and full-wet conditions, respectively, for the total of 13 replaceable coil heads. For conditions measured with both a thermocouple and an IR camera, all thermocouple measurements were between the minimum and maximum across-coil IR camera measurements and equal to 74% ‒ 115% of the across-coil mean, depending on test conditions. The IR camera showed details of the non-uniform temperature distribution across heating coils. The large temperature variations under wet-through-wick conditions may explain the large variations in formaldehyde formation rate reported in the literature for such “top-coil” clearomizers."

A za one sto ih mrzi da citaju sve :"Among experienced users who took 30 puffs in 10 minutes, the pod-based ENDS delivered a mean nicotine boost of 28.6 ng/mL in a mean of 8.7 minutes. This is higher and faster than the mean nicotine boost obtained from “cigalike” ENDS devices (puff activated and similar size and shape as a traditional tobacco cigarette; 1.8 ng/mL, 10 minutes) and advanced ENDS devices (button-activated with larger battery; 10.8 ng/mL, 12.1 minutes) using the same puffing schedule.4 These users also self-reported higher nicotine dependence on the PSECDI, compared with 3609 experienced long-term users of other ENDS devices (mean PSECDI score, 8.1).This study is the first, to our knowledge, to show that JUUL delivers a higher and faster boost in blood nicotine than has been reported for most other ENDS devices.4-6 Limitations are the small sample size and that ENDS users may not typically take 30 puffs in 10 minutes. However, its use produced a mean (SD) nicotine boost of 12.9 (9. ng/mL after only 12 puffs in 4 minutes, a rate suggestive of pulmonary absorption. Compared with studies reporting the nicotine boost obtained after smoking 1 cigarette, this product’s nicotine delivery was similar.4,6 The nicotine delivery capabilities of this ENDS device may contribute to its addictiveness as well as its ability to compete with cigarettes for market share."

"Both standard and systems toxicology endpoints demonstrated very limited biological effects of the tested FGR mixture. When tested at elevated levels in excess of those typically used in commercial products, the FGR mixture did not increase the inhalation toxicity. Several adaptive changes due to nicotine exposure have been observed, but no major adverse effects were caused by the FGRs in e-liquid. Because of the study design with multiple FGRs in the mixture, it can be concluded that there were no apparent additive or synergistic toxic effects among the flavoring substances as they were tested."