Abstract

Four compounds, R3PAu[S2CN(CH2CH2OH)2], R=Ph (1) and cyclohexyl (2), and Et3PAuS2CNRꞌ2, Rꞌ=Rꞌ=Et
(3) and Rꞌ2 = (CH2)4 (4), have been evaluated for antibacterial activity against a panel of 24 Gram positive (8)
and Gram negative (16) bacteria. Based on minimuminhibitory concentration (MIC) scores, compounds 1 and 2
were shown tobe specifically potent against Grampositive bacteriawhereas compounds 3 and, to a lesser extent,
4 exhibited broad range activity. All four compounds were active against methicillin resistant Staphylococcus aureus
(MRSA). Time kill assays revealed the compounds to exhibit both time- and concentration-dependent pharmacokinetics
against susceptible bacteria. Each compound was bactericidal against one or more bacteria with 3
being especially potent after 8 h exposure; compounds 1 and 3were bactericidal againstMRSA. Compound 3 was
the most effective bactericide across the series especially toward B. subtilis, S. saprophyticus, A. hydrophila, P.
vulgaris, and V. parahaemolyticus. This study demonstrates the potential of this class of compounds as antibacterial
agents, either broad range or against specific bacteria.

Item Type:

Article

Additional Information:

First, 3rd, 4th, 5th, and 6th authors are with Department of Biomedical Science, Faculty of Medicine and Health Sciences, University Putra Malaysia; 2nd and 7th authors are with Department of Chemistry, University of Malaya; 8th author is with Department of Biological Sciences, Faculty of Science and Technology, Sunway University; 9th author is with Research Centre for Crystalline Materials, Faculty of Science and Technology, Sunway University