A.In Episode 5, of the final Season 7 ("Lost Cause").Eric & Pam are hunting for Sarah Newlin, who is responsible for
infecting the Tru-Blood supply with the deadly Hep-V virus.

After visiting the Dallas home of Sarah's sister (Amber Mills), Eric & Pam learn that Sarah is in Dallas, and that she will most likely show up at a Republican gala for Ted Cruz, being held at the George W. Bush Library.

So, Eric & Pam dress up as conservative Texans (complete with Stetson) and show up at the gala.

Sarah
tracks down her mother in the restroom and tells her she's in trouble,
that the Yakuza are after her, and asks for help in contacting Laura
Bush.

Eric glams Sarah's father, but he doesn't know where she is.

Just
them the Yakuza crash the party, bursting into the Library with
automatic guns blazing. They shoot up the room and kill Sarah's
father.

Sarah
& her mother try to escape down a back hallway, but her mother is
shot & killed by the gunmen. And then the fleeing Sarah runs
right into Eric.

He
is about to kill her, when he spots someone he hates even more: the
Yakuza assassin who killed his girlfriend, long ago, in France.
He drops Sarah and slaughters the Yakuza.

The
location:The Bush Library Gala

In the next episode (#6), Eric & Pam are taken prisoner in that hallway by the head of the Yakonomo Corporation (the company which makes Tru-Blood), and are moved, in chains, to their headquarters.

Q.
What is it actually, in real life?

A.A museum and cultural center.

Q.
Where can I find it in real life?

A.They originally wanted to shoot this scene
at the Chino Hills city hall, because it supposedly bore a strong
resemblance to the actual Bush Library. But politics got in the
way when local opposition reared its head, and they pulled out of the
deal (probably to the relief of local politicians, who would have had to
make a call on the issue).

To be more precise, it was shot in the Ahmanson Ballroom, on the north side of the center's campus. The large room is officially named the Cotsen Auditorium and seems a popular spot for weddings and other celebratory events.

The Skirball Center started out as a small museum, originally
located near USC, dedicated to the Jewish experience &
history. It grew over the years, and in 1996 moved to this much
larger venue. In addition to the museum, the new campus also
features a performing arts center, conference halls, classrooms,
libraries, gardens, and a café.

If you have ever driven the San Diego (405) Freeway as it cuts through
the Santa Monica mountains between West L.A. and the Valley, you have
driven right past the Skirball Center. It's perched near the
middle of the Sepulveda Pass, just south of Mulholland Drive.
It's the smaller of two notable museums located along this stretch of
the 405, the other being the well-known Getty Center, which anchors the
Pass's south end.

( You can read more about the Skirball Center at their website, here. )

Here is a photo of the Skirball Center:
Here is an interior shot of the center's Ahmanson Ballroom:(which, you will notice, matches the screenshot at the top right of this page)

A. I
first visited the Skirball Museum back in the late 1980's, when it was
a small museum tucked away near USC. I didn't immediately recognize the
ballroom, dressed up, as it was to look like the Bush Library.
But when I took a closer look at the scene, I first noticed the unusual
doors (through which the Yakuza enter), which looked familiar.

Then
something else caught my eye on a second look, that I had
missed the first time around. At the very start of the gala
scene, the camera pans down from a rather ornate silver ceiling
ornament, to reveal the stage and the Bush poster. That silver
ceiling can be found in the Ahmanson Ballroom, as seen above.
Google easily turned up photos of the Skirball Center matching those
items.