Prignitz is a Kreis (district) in the northwestern part of Brandenburg, Germany. Area 2123 kmē, population 99,000 (1997). The district's capital is Perleberg[?].

The term Prignitz originally means the region north of the confluence of the Elbe and Havel rivers. This region is larger than the district and also includes large portions of the neighbouring district of Ostprignitz-Ruppin.