"The general term for a low-ranking goddess in Norse mythology, a kind of spirit.The Disir are said to have given birth to Valkyries, warrior maidens, and Norns, goddesses of fate, in response to the desires of humans for bountiful harvests and victory in battle."

—Shin Megami Tensei IMAGINE compendium

A variety of Dis can be found in the docks area of Shinjuku Babel. They appear alongside Thor in the boss room of Celu Tower's gold instance.

A trio of non-recruitable Disir appear in Sector Bootes. They used to possess time-based powers, until the rampaging Yggdrasil stole them for his own benefit and empowered himself as a powerful monster with full mastery above time, giving him the ultimate edge in battles. Desperate for help, the Disir encountered the protagonist and convinced him to attempt to destroy Yggdrasil, teleporting him to Sector Eridanus.

The Disir were, however, confused to see a second version of the protagonist pop up just as soon as the first one had been nearly killed by the rampaging tree; at this time, the sisters' combined future form, Norn, canceled the stolen powers, removing Yggdrasil's edge and leaving him open for a counterattack. Realizing they were meant to eventually reach the power of Norn and send the protagonist into the past with their restored powers, they sent back the past protagonist to Bootes with no memory of the fight and rewarded him, instructing him to remember he still has yet to destroy Yggdrasil for good before the ontological paradox was completed and the loop closed.

Dis can be found in Shibuya. She can teach Flynn the Lullaby and Mediarama skills through her Demon Whisper.

A non-hostile Dis appears in the Challenge Quest, The Only Food Source, after Tlazolteotl has been defeated. She reveals that demons had been sent by the Gods to kill humans and revealed Tlazolteotl's past and her intentions behind keeping the corn. Dis' job was to transport the souls purified by her and asks Flynn to treasure the memories of the dead and the gift from Tlazolteotl.