* Setsumi in ''VisualNovel/{{Narcissu}}'' has an unnamed condition. [[spoiler: She kills herself at the end of the story.]]* Miku in ''VisualNovel/AProfile'' as a result of a slightly botched liver transplant.* Toko in ''VisualNovel/KaraNoShoujo'' is anemic and spends a lot of time sleeping. She also requires some special medicine. All in all, though, it's not too bad [[spoiler:until Mizuhara thinks it's some sort of drug, steals it and Toko ends up getting hit by a truck when she passes out.]]* ''VisualNovel/{{Ever 17}}'' features two: [[spoiler: Yubiseiharukana (the You from Takeshi's path)]] who has a terminal heart condition and [[spoiler: Coco Yagami]] who has [[IncurableCoughOfDeath Tief Blau]].* ''VisualNovel/FateStayNight'':** In the "Heaven's Feel" arc, Sakura is revealed to be this, due to the stress of the Matou family's crest worms becoming more active. [[DeusSexMachina Shirou has a treatment for her]], at least temporarily.** Additional materials reveal the existence of another ill girl: [[spoiler:Kirei Kotomine's dead wife, [[http://typemoon.wikia.com/wiki/List_of_minor_characters_in_the_Fate_series#Hortensia Claudia Hortensia]], an inmuno-deficient MysteriousWaif who passed away two/three years after they got hitched. (In a subversion, she actually commited suicide in a desperate gambit to prove him that he wasn't as unfeeling as he thought -- then again, Claudia ''was'' already dying so she wouldn't have lasted much longer anyway).]]* Miyu Shizuhara from ''VisualNovel/{{Crescendo}}''. Her illness isn't specified, but it requires her to stay at the hospital for a good part of her route. [[spoiler: And she does NOT get better.]]* All the main girls in ''VisualNovel/KatawaShoujo''; in fact, the game started out as an attempt by Website/FourChan to create the video game with the highest Ill Girl count possible. Though [[SubvertedTrope ironically enough]], only the male protagonist's condition is actually life-threatening, since the heroines are all in some way physically disabled but otherwise healthy. There is one Ill Girl that plays this trope straight: Saki Enomoto from the Aprils Fool "Event", whose disease (spinocerebellar ataxia) [[YourDaysAreNumbered will eventually kill her]].* The eponymous Kana from ''VisualNovel/KanaLittleSister''. The cause of her disease is clearly stated: [[spoiler:kidney failure]]. The game also features Sumako and Cana. [[spoiler: Two of the three die.]]* Creator/KeyVisualArts has at least one, sometimes more, in every game. They use this trope so often that fans have started jokingly referring to any SoapOperaDisease as [[MemeticMutation KeyAIDS]].** ''VisualNovel/{{Kanon}}'' has Shiori (who is terminally ill).** ''VisualNovel/{{Clannad}}'' has Nagisa (unnamed illness that [[spoiler: may have supernatural origins]]) [[spoiler:, Fuko (is in a coma after an accident)]], and [[spoiler: Ushio (her mom Nagisa's same illness)]]** ''VisualNovel/{{AIR}}'' has [[spoiler:Misuzu, whose illness is actually ''born from a curse'']].** ''VisualNovel/{{Planetarian}}'' has [[spoiler:Reverie/Yumemi, with low battery power and unable to recharge due to planetarium's backup power supply failure just after the show, and that they're stuck in post-apocalypic Earth]].%%%** ''VisualNovel/LittleBusters!'' has Mio. [[spoiler:Or does it?]]* Yuzuha in ''{{Utawarerumono}}'', who is actually something of a MacGuffin - her brother Oboro's theft of the outrageously expensive medicine she needs to survive is the start of a chain of events which snowball into an international war.** [[spoiler: In the third installment of the Utawarerumono franchise, it's revealed that her daughter [[VideoGame/UtawarerumonoItsuwariNoKamen Kuon]] of all people inherited the disease from her, though thanks to her [[PhysicalGod father's blood]] in her [[SemiDivine veins]], it isn't as fatal, but she'll suffer relapses from it every now and then.]] Very surprising considering her healthy disposition and attitude in the second game.* ''VisualNovel/UminekoWhenTheyCry'' has Jessica Ushiromiya, who's a very atypical case - an asthmatic {{Tsundere}} who later on becomes a CuteBruiser. However, early on, she tends to have very poorly-timed attacks that make her something of a BadassInDistress.** It's later revealed that [[spoiler: Jessica partially ''faked'' some of these attacks [[DecoyDamsel to make herself look more helpless than she truly was]] in order to get out of awkward or uncomfortable situations.]]** Ange also was one when she was younger, as being afflicted with a severe cold is what preventing her from going to the 1986 family conference. She was also noted to often be sick aside from that instance.* Played with in ''VisualNovel/EfAFairyTaleOfTheTwo'': Chihiro Shindou doesn't spend almost any time bedridden or hospitalized, but she still suffers the serious consequences of having been hit by a car three years prior to the story ([[spoiler: the loss of an eye that she covers with a white eyepatch, and retrograde amnesia that takes effect every 13 hours]]), so she requires to be taken care of. In short: Chihiro is an Ill Girl turning into a BandageBabe when she got better.* Another Chihiro with a bad health is Chihiro Fujisaki from ''VisualNovel/DanganRonpa'', who never had the strength to go out and play with others as a little girl. [[spoiler: Except Chihiro is an ill ''boy'', not an ill girl, and one of the reasons why [[DisguisedInDrag he crossdressed]] was because he was considered "too weak" as a boy and was bullied for it, so he tried to protect himself via crossdressing. And we don't find out until we find him ''dead''.]]** In ''VisualNovel/SuperDanganRonpa2'', [[spoiler:there's Teruteru Hanamura's mother, who had worked herself to illness and exhaustion to keep the family restaurant open. Teruteru worries a lot about her health, and his desire to get off the island to find out if she's alright eventually drives him to murder.]]* ''VisualNovel/DaCapoII'': There is a double example in one route: [[spoiler: Anzu. Said girl was the first to fall ill, then comes the protagonist boy's turn. They both spoon spoonfeed soup to each other when the other one lies sick in bed.]]%%%** In another route, there is [[GenkiGirl Yuzu]].* ''VisualNovel/EdenTheyWereOnlyTwoOnThePlanet'' centers around a [[OlderThanTheyLook 100 year old genetically engineered]] sick girl Sion.* Viola Cadaverini from ''VisualNovel/PhoenixWrightAceAttorney'' looks like one given her pale and creepy/sickly appearance as well as the bandage on her head. She's a bit of a subversion, though, since the bandage is due to an injury [[spoiler: that she got in a ''massive'' accident caused by her sort-of love interest Furio Tigre]] and it is implied that she is just a frail woman by physical nature, not illness.* ''VisualNovel/IfMyHeartHadWings'': Isuka, Amane's old friend, was very susceptible to illness and at least strongly believed that she would probably die young. Though unlike most, she was always much more boisterous and energetic than delicate, with a more 'live life to the fullest' mindest.* ''VisualNovel/NineHoursNinePersonsNineDoors'' has Akane Kurashiki a.k.a. June, who is very disturbed by the events of the game and breaks out into severe fevers at several points. [[spoiler:They are caused by Junpei straying off the path that leads to the GoldenEnding and creating a TemporalParadox that incinerates her nine years prior.]]* In VisualNovel/TrueLoveJunaiMonogatari, we have local artist Miyuki Tanaka. She has anemia and a very low threshold for either extreme heat or vigorous physical activity, leading her to pass out while on the sidelines of the swimming competition if she shows up there [[spoiler: and kinda worries the PlayerCharacter during their sex scene.]]

!!Male Examples

* ''VisualNovel/KatawaShoujo'' gives us two:** Male lead Hisao. While the girls are physically disabled but otherwise fine, he's got ''severe'' [[HeartTrauma heart arrhythmia]] that almost kills him in the introduction. It doesn't do him any favors when [[CrashIntoHello Emi runs into him in the hallway]], either, and keeps being a problem over the course of the game. [[spoiler: ''Especially'' in Lilly's route, in which he has two major incidents... and a ''third'' on the way to the Good Ending that hospitalizes him again ''and almost kills him''.]]** Kenji Setou, who not only is legally blind but is speculated to be mentally ill as well. Only that he's a LargeHam ConspiracyTheorist instead.* Shiki Tohno from ''VisualNovel/{{Tsukihime}}'' fits into the role in two different respects. The accident that didn't quite kill him still left him with poor health and occasionally life-threatening anemic attacks. On a more subtle but drastic level, his Mystic Eyes of Death Perception growing constantly stronger means [[spoiler:his lifespan is cut extremely short, and he's likely to die before long when his brain overloads.]]* [[spoiler: Sakura Oogami's boyfriend Kenichirou]] in ''VisualNovel/DanganRonpa'', as revealed [[RelationshipValues by the Free Time talks.]] Even more so: [[spoiler: Sakura explains to Naegi that Kenichirou was ''terminally'' ill and [[AlwaysSomeoneBetter she never could beat him in martial arts]], so he gave her the title of strongest person when he learned that [[YourDaysAreNumbered he had just six months to live]].]] [[FridgeHorror It's even worse]] when you realize that [[spoiler: between two years actually having passed and the Worst, Most Despair-Inducing Incident in the World taking place, there's a high chance that Kenichirou is dead by time Sakura commits suicide.]]** There's also [[spoiler:Chihiro Fujisaki; see above.]]** In ''VisualNovel/SuperDanganRonpa2'', [[spoiler:Nagito Komaeda is apparently this, specifically having dementia and stage three malignant lymphoma, and it's implied that his illnesses were what [[DiseaseBleach turned his hair white]]. While in the game it's unclear whether or not he's actually telling the truth about having these illnesses, supplementary materials have supported his claims.]]* Although Creator/KeyVisualArts is well-known for its ill girls (see above), ''VisualNovel/LittleBusters'' has two male examples [[spoiler:and no real female examples, as while Mio is very delicate and seems sickly at first, her issues are very different.]] Most obviously there's Riki, the very {{Moe}} protagonist, who suffers from narcolepsy. [[spoiler:And secondly there's Komari's older brother, who suffered a deadly disease that killed him when Komari was only a small child.]]** And [[spoiler:Ryou's SecondLove Kappei Hiiragi]] from ''VisualNovel/{{CLANNAD}}'', who has bone cancer. [[spoiler: He either has to get his leg amputated or die.]]* Hiroki from ''VisualNovel/PrivateNurse''. However, there are implications that [[spoiler: his sickness is at least as much psychosomatic as physiological and that he needs to convince himself that he can get better.]]----