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“Even though the [U.S.] numbers are small, they are of considerable interest,” CDC Director Dr. Tom Frieden said during a news conference Friday. “We understand that the occurrence of fetal malformation, fetal loss or miscarriage, or a child with a birth defect, is something that can be devastating to a family.”

The proportion of U.S. pregnancies that appear to have been harmed due to the mosquito-borne infection “is unexpected, and greater than we would have expected,” Dr. Denise Jamieson, co-lead of the Pregnancy and Birth Defects Team with the CDC Zika Virus Response Team, said during the news conference.

Of the remaining four women, two gave birth to apparently healthy babies and two pregnancies are continuing without known complications.

Those numbers reflect confirmed cases as of Feb. 17. Ten additional reports of Zika infection involving pregnant U.S. women are currently under investigation, the CDC added.

Genetic evidence of Zika virus was detected in tissue specimens from the two miscarriages. The CDC was careful to say it is not known whether Zika caused the miscarriages, but Frieden noted that the presence of the virus in fetal tissue is highly suspicious.

In an updated travel alert issued Friday evening, the CDC offered several cautions for people planning to attend the 2016 Summer Olympics in Rio de Janeiro, Brazil. The agency suggested that pregnant women consider not going to the games and that if their male partners go, the couple should use condoms after the trip or abstain from sex during the pregnancy.

If a pregnant women decides to go to the Summer Olympics, she should talk with her doctor before leaving, the CDC advised in the latest alert.