Innovation is perceived by the general public as something that has a positive effect on life expectancy or quality of lifex0201d. [ I3 ] Economic importance. Investments made by the government or the pharmaceutical company in the development of the drug may well be considered in reimbursement decisions. x0201c;In my experience, if research is supported by the government, to support the development of orphan drugs, thatx02019;s good, but it also leads to the expectation that reimbursement is the icing on the cakex0201d.