beta-amyloid

beta-amyloid

(bā′tə-ăm′ə-loid′, bē′-)

n.

A protein fragment formed by the cleavage of amyloid precursor protein that aggregates into deposits characteristically found in the brains of people with Alzheimer's disease. Also called amyloid beta-peptide, amyloid beta-protein, beta-amyloid peptide, beta-amyloid protein.

Neuraceq PET Shows High Sensitivity and Specificity and High Predictive Value for Detection of Neuritic Beta-amyloid Plaques; May Be Valuable Adjunct to Clinical Diagnosis of Alzheimer's Disease and Other Dementias

PET scans using radio-labeled flutemetamol were safe to use in vivo and confirmed the presence or absence of neuritic beta-amyloid levels "with high sensitivity and specificity" in a phase III trial involving 68 terminally ill older adults.

Researchers at the Johns Hopkins Bloomberg School of Public Health, who examined the association between sleep variables and a biomarker for Alzheimer's disease in older adults, found that reports of shorter sleep duration and poorer sleep quality were associated with a greater beta-Amyloid burden, a hallmark of the disease.

TEHRAN (FNA)- Scientists at the Stanford University School of Medicine have shown how a protein fragment known as beta-amyloid, strongly implicated in Alzheimer's disease, begins destroying synapses before it clumps into plaques that lead to nerve cell death.

Dr Giulio Maria Pasinetti, The Saunders Family Professor in Neurology at Mount Sinai School of Medicine headed the research which is the first of its kind and examines the ability of grape-derived polyphenols to prevent the generation of a specific form of beta-amyloid peptide, a substance in the brain long known to cause the neurotoxicity associated with Alzheimer disease.

Professor Martins is credited, in collaboration with Australian and German scientists, with isolating beta-amyloid protein, which forms amyloid plaque deposits in the brain, a characteristic diagnostic feature of Alzheimer's disease.

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