This paper analyzes the big trip phenomenon, restricting it to happen only in the context of the multiverse when the involved wormhole is asymptotically flat and recent criticisms are pointless. A new kind of Lorentzian asymptotically anti-de Sitter wormholes is considered in some detail and it is seen that such wormholes cannot contribute the big trip phenomenon. The ideas of big trip, multiverse and Boltzmann brains are then used to advance the conjecture of cosmic transmutation according to which the host universe where one of the mouths of a grown up wormhole is inserted may be converted into a universe similar to the traveling one if the latter contains a civilization which is typical also in the host universe. The origin of life in the context of the multiverse is then briefly discussed.