Report on medical disorders plaguing the Amish, which stem from the founder effect. The Amish are allowing mainstream doctors to study their conditions, in hopes of helping both sick Amish children, as well as potentially learning about more common neurological disorders.

"Marla" profiles a controversial four-year-old artist. "His Year in Hell" examines the case of Maher Arar a Canadian citizen who was sent to Syria to be tortured because he was believed to be a terrorist. "South Kent Cardinals" looks at the revitalization of a prep school through basketball. "Telemarketing Calls" features Steve Hartman examining telemarketers.

"The Boys Next Door" looks at the case of two 12-year-old boys who are accused of killing their playmate. "Whoosh" looks at the dangerous sport of speed skiing. "Ventriloquist Convention" features Candice Bergen visiting a convention of ventriloquists. "What Makes Art, Art?" looks at conceptual art.

"Stressed Cells" examines the impact of stress on our DNA and how it can hasten the aging process. "AARP" looks at the influence of the organization on government policy. "Camille" revisits a coupe who adopted fifteen seriously ill children. "The Awful Truth" looks at brutal double murder of Julie Godwin and Elizabeth Ober in South Africa.

"Katrina" takes a look at the destruction caused by Hurricane Katrina. "Great Expectations" follows an unusual experiment where a problem student is given a second chance in a boarding school. "Shadow Divers" interviews two deep-sea divers who explored a WWII German submarine off the coast of New Jersey.