Step up your biologics stability screening with Hunky

Lisa Adamiak is an Applications Scientist at Unchained Labs. She is responsible for supporting new product development for protein analytical tools by carrying out proof-of-concept studies. Lisa received her PhD in Chemistry from UC San Diego, where she synthesized and characterized biological nanomaterials for diagnostic applications.

Abstract

DATE: June 28, 2018
TIME: 9:00AM PDT

Step up your biologics stability screening with Hunky

Many methods for studying protein stability and aggregation are qualitative, which can cause uncertainty when moving drug candidates and formulations forward. In contrast, Hunky gives you the Gibbs free energy (ΔG) of a protein, which is a powerful and quantitative indicator of the amount of unfolded protein present in a sample at ambient temperatures. Moreover, inherent in the ΔG values is information about the likelihood and pathway of aggregation of the protein.

In this webinar, Dr. Lisa Adamiak will discuss the benefits of making routine ΔG measurements with Hunky as part of the process of developing biologics and optimizing formulations. This quantitative data can be used in conjunction with orthogonal and more traditional thermal melting measurements Tm to reduce risk when developing biologics.

Learning Objectives:

• See how ΔG provides quantitative information on protein stability compared to other stability measurements

• See how ΔG can give insights into protein aggregation

• Learn how Hunky makes it easy to implement these measurements as part of your routine process