Anti-MBP T cell receptor (Hy.1F9), pCDTCR1(TCR-C155Z)

The vector of anti-MBP T cell receptor (TCR) is constructed for the engineering of T cell to target Human MBP. The T cells are genetically modified through transduction with a lentiviral vector expressing MBP-specific T cell receptor. And the vector product was designed for the treatment of Multiple sclerosis (MS).

Details

Target

MBP

Target Species

Human

Epitope

aa 84-102

Format

Non-modified

HLA

HLA-DR2

Targeting Diseases

Multiple sclerosis (MS)

Vector Name

pCDTCR1

Vector Length

~8kb

Vector Type

Lentiviral

Antibody Clone

Hy.1F9

Antibody Host

Human

Target

The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long MBP gene (otherwise called "Golli-MBP") that contains 3 additional exons located upstream of the classic MBP exons. Alternative splicing from the Golli and the MBP transcription start sites gives rise to 2 sets of MBP-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-MBP, spliced in-frame to 1 or more MBP exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to MBP aa sequence. The second family of transcripts contain only MBP exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the MBP transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.