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Drug synergism: The combined effects of fluoxetine and memantine on an animal model of obsessive compulsive disorder

International Conference and Exhibiton on Pharmaceutical Regulatory Affairs

Abstract

O
bsessive Compulsive Disorder (OCD) is currently treated with behavioral modifi
cation
and psychotropic medications, with varying degrees of success. Th
e most popular drugs
for the treatment of OCD are the selective serotonin reuptake inhibitors (SSRIï¿½s). Another drug,
the Nï¿½methylï¿½Dï¿½aspartate antagonist memantine, has recently been tested in the treatment
of OCD. Th
e present study investigates the eff
ect of fl
uoxetine and memantine alone and in
combination on a mouse model of compulsive behavior. In this model, compulsive scratching is
induced by a subcutaneous injection of serotonin or a serotonin releasing agent, compound 48ï¿½
80, in the back of the neck. Th
e eff
ects of memantine and fl
uoxetine combination were found to
be synergistic, specifi
cally as defi
ned by an isobologram. Th
e results of the present investigation
suggest the potential of a more eff
ective management of the symptoms of OCD.

Biography

Dr. Raphael Wald is a licensed psychologist practicing in Boca Raton, Florida. He has a range of experiences including individual therapy and neuropsychological assessment. Dr. Wald has worked with individuals of all ages, from young children all the way through older populations, typically addressing concerns related to depression, anxiety, and neurologic disorders. Dr. Wald has also conducted research for a number of years at Tufts Medical Center in Boston. He has been published as a fi rst author in the Journal of Experimental and Clinical Psychopharmacology, and has published a book focusing on the causes and treatment of Obsessive Compulsive Disorder