* Synthetic biology is an exciting new field that aims to create novel biological functions by artificially combining natural molecular parts. Rational design allows us to engineer the behaviors of protein-based drugs, in ways that we cannot accomplish with small molecule-based drugs. DNA assembly will be used to build a combinatorial library of over 200 synthetic transcription factors (Pc-Tfs) that will potentially activate therapeutic genes in cancer and stem cells. As time allows, a select group of Pc-TF protein will be purified and analyzed biochemically.

* Synthetic biology is an exciting new field that aims to create novel biological functions by artificially combining natural molecular parts. Rational design allows us to engineer the behaviors of protein-based drugs, in ways that we cannot accomplish with small molecule-based drugs. DNA assembly will be used to build a combinatorial library of over 200 synthetic transcription factors (Pc-Tfs) that will potentially activate therapeutic genes in cancer and stem cells. As time allows, a select group of Pc-TF protein will be purified and analyzed biochemically.

==Notes==

==Notes==

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* Brady Laughlin's Spring 2012 project in the Haynes Lab at Arizona State University

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* Brady Laughlin's Spring/Fall 2012 project in the Haynes Lab at Arizona State University

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* BME 394 Honors Research Spring 2012 and Fall 2012

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*Brady was accepted into the Fulton Undergraduate Research Initiative (FURI) for the Spring 2013 and Fall 2013 semesters.

Revision as of 08:58, 3 September 2013

Project Description/Abstract

Synthetic biology is an exciting new field that aims to create novel biological functions by artificially combining natural molecular parts. Rational design allows us to engineer the behaviors of protein-based drugs, in ways that we cannot accomplish with small molecule-based drugs. DNA assembly will be used to build a combinatorial library of over 200 synthetic transcription factors (Pc-Tfs) that will potentially activate therapeutic genes in cancer and stem cells. As time allows, a select group of Pc-TF protein will be purified and analyzed biochemically.

Notes

Brady Laughlin's Spring/Fall 2012 project in the Haynes Lab at Arizona State University

BME 394 Honors Research Spring 2012 and Fall 2012

Brady was accepted into the Fulton Undergraduate Research Initiative (FURI) for the Spring 2013 and Fall 2013 semesters.