Ukrain

Is it safe?

Adverse events

Ukrain is claimed to contain a derivative of thiophosphoric acid, which could cause severe and life-threatening adverse effects.

A literature review of possible cases caused by Chelidonium majus found that it may induce hepatitis and several cases of hepatitis-induced by consumption of Chelidonium majus were found.37 The researchers suggest there might be a probable relationship between liver injury and consumption of Chelidonium majus.

Contraindications

No contraindications of Ukrain have been given by providers, proponents or manufacturer.11 Like with all orally applied medicines, the use of Ukrain during pregnancy and lactation are contraindicated.

Precautions/warnings

Ukrain contains a derivative of thiophosphoric acid, which could cause adverse effects, contraindications and/or interactions associated with other hazardous drugs of this class of chemicals.

Adverse effects

Soreness at injection site, nausea, diarrhoea, dizziness, fatigue, drowsiness, polydipsia, polyuria, and slight fever have been reported.21,38 Haematological side effects and tumour bleeding were reported in a recent phase II trial. Severe bone marrow toxicity may occur after 15 to 20 days of treatment.23 Liver toxicity has been observed.39

Quality issues

Citation

Document history

Assessed as up to date in February 2017 by Barbara Wider.
Assessed as up to date in January 2015 by Barbara Wider.
Assessed as up to date in August 2013 by Barbara Wider.
Most recent update and revision in May 2012 by Katja Boehm.
Fully revised and updated in July 2009 by Katja Boehm.Summary first published in November 2005, authored by Katja Boehm and Edzard Ernst.

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