Associated products

Applications

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application

Abreviews

Notes

WB

1/500 - 1/3000. Predicted molecular weight: 55 kDa.

Target

FunctionOrganizes filamentous actin into bundles with a minimum of 4.1:1 actin/fascin ratio. Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers. Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration.

Tissue specificityUbiquitous.

Sequence similaritiesBelongs to the fascin family.

DomainComposed of four beta-trefoil domains.

Post-translationalmodificationsPhosphorylation on Ser-39 inhibits the actin-binding ability of fascin.