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SUBSTANCE: invention relates to ecology, specifically to assessment of quality of atmospheric air of residential places based on state of epiphytic lichen flora. For this purpose, method includes calculating air pollution index (API) based on vitality of lichen within 89 %, comparing it with a complex index defined on account site, and tolerance factor of lichen flora in relation to air pollution index, which is calculated by formula API=(0.89-G/89)/0.298, where 0.89 is maximum relative vitality of lichen flora in pure air; G% is a complex index of vitality of lichen flora on lichen indication site; 89 % is theoretically possible maximum vitality of lichen flora in pure air, expressed in percentage; 0.298 is tolerance factor of lichen flora to API. Value of API of about 1 and presence of all types of lichen indicates favourable ecological situation and quality of atmospheric air; a score within 5-6 units indicates elevated pollution; a score of 7-13 characterises high pollution; a score above 14 characterises very high pollution.

SUBSTANCE: simulator of tuber damageability comprises a housing made fixed carcass in the form of a hexagonal parallelepiped elongated horizontally at the vertices of which the chain sprockets are mounted, and a rod web is tightened on the housing, comprising a window for loading, a fork-shaped blade and an ellipse shaker. In the centre of the simulator a horizontal rotary separator is mounted.

EFFECT: invention improves the accuracy of determining the potato tuber damageability by bringing the experimental test conditions to the actual conditions of mechanical harvesting potatoes.

SUBSTANCE: invention relates to methods of preparing hydrocarbon gases for transfer by low-temperature separation and can be used in oil and gas industry. Method of low-temperature gas separation consists in fact that three-stage separation of raw gas is performed to obtain condensate and gas at first stage, which is divided into two parts, one of which is cooled down by third separation stage gas under dephlegmation conditions to produce first gas and condensate flows, another is cooled down by condensates mixture under dephlegmation conditions to produce second gas and condensate flows, then first and second gas flows are mixed with formation of second separation stage gas, and first and second condensate flows are mixed with first separation stage condensate, throttled, mixed with third separation stage condensate and stabilized by indirect heating first separation stage gas second part counterflow to produce stabilized condensate and weathering gas, and second separation stage gas is throttled, mixed with weathering gas and separated at third stage with production of condensate and gas, which is heated and brought out from plant as commercial gas.

SUBSTANCE: invention relates to medical diagnostics and concerns prediction of intensity of pain syndrome in early postoperative period in patients with chronic calculous cholecystitis, Russian ethnicity, which are natives of Central black earth region of Russia. Method involves blood sampling and DNA recovery from peripheral venous blood. After DNA is recovered, analysis of polymorphisms of genes IL-1A -889T>C, IL-5 -703C>T and more evident pain in patients with chronic calculous cholecystitis in 18 and 22 hours of first day after cholecystectomy if observing genotypes -889TT and -889CT IL-1A.

EFFECT: intensive predicted pain sensations in 8 hours of second postoperative day if observing genotypes -703CT and -703TT IL-5.

SUBSTANCE: device comprises plastic hard case made with possibility of fixation on the wrist in the hose of clothes and bloodworm box placed in the case of small volume. Bloodworm box is pressed to the rear wall of case due to tension of gum fixed between them. Bloodworm box can be extended from the case by attached thread.

EFFECT: invention provides extraction of fishing bait from bloodworm box with one hand.

SUBSTANCE: invention relates to ammunition, specifically to cartridges for smooth-bore guns and can be used for shooting from 12, 16 calibre smooth-bore guns. Universal shell with propellant charge consists of shell flange, metal base of shell, polyethylene or plastic shell, powder. Instead of shot or bullet, universal shell used is harpoon, which is equipped with piston rings, which powder gases are pushed out of channel of smooth-bore gun. Harpoon is not integrated with universal shell, and is connected to shell through muzzle bore gun before shooting. Monitoring of location of harpoon after shooting is performed using a cord, one end of which is located movable ring of harpoon, and second end is wound on a coil, which is located next to gun and unwinds at moment of shooting.

EFFECT: result is possibility of firing harpoon from 12 and 16 calibre guns.

SUBSTANCE: invention relates to devices for manual launching of signal and lighting flares. Launching device comprises guide container with spiral grooves, basing arches, profiled under bearing cantilever shaft of small arms, and a mechanism for manual initiation, made in form of loaded spring firing device.

SUBSTANCE: invention relates to a ropeway device for transportation of people or cargoes. Device for a ropeway for transportation of people or cargoes has two pairs of bearing ropes (31, 32) propagating between two end stations, namely the lower end station and the upper end station, along which by means of at least one pull rope (5) transport facilities can move. Bearing ropes (3) in the area of at least one support have a curved path on the top view. Pull rope (5) in the area of the said at least one support (4) is laid through support rollers (8a). Herewith at least some of located in the area of the said at least one support (4) of support rollers (8a) of the said at least one pull rope (5) can be relocated as to their position relative to both bearing ropes (3) in vertical and horizontal directions to a position approximately under pull rope (5).

EFFECT: result is higher wear resistance of elements of the ropeway, in particular, of support rollers.

SUBSTANCE: present invention relates to the methods for operating a vehicle as it approaches an intersection with a traffic control device. Method embodiments include the following steps: detecting a traffic control device at an intersection the vehicle is approaching, and releasing and applying a disconnect clutch arranged in a driveline of the vehicle intermediate the engine and starter/generator based on the type of the detected traffic control device. Because releasing the disconnect clutch disconnects the engine from the vehicle driveline, the engine may be turned off to increase fuel efficiency while the disconnect clutch is released.

SUBSTANCE: group of inventions relates to automotive industry. Brake shoe for an inbuilt in a wheel disc brake comprises a bearing friction lining plate in the form of a circular segment at its rear side facing from the friction plate comprising two spaced apart moulded stops. Distance between centers of the stops is from 125 to 135 mm, herewith the distance between the stops centers to surfaces of fit makes from 48 to 58 mm. According to the first version, in the brake shoe for an inbuilt in a wheel 19.5 inch diameter disc brake the length of the bearing plate is from 205 to 220 mm. According to the second version, in the brake shoe for an inbuilt in a wheel 22.5 inch diameter disc brake the length of the bearing plate is from 245 to 250 mm.

SUBSTANCE: invention relates to machine building, in particular, to machines parts, and can be used in tooth gears. Gear wheel includes body and toothed rim with teeth, in sections of which heads width of their side surfaces is made stepped varying and inversely proportional dependent of engagement pairing. Width change boundary is shifted towards teeth tops on value of transmission axial clearance half. Teeth are made asymmetric and have in their central cross sections of upturned “L” type, which vertical component height is equal to toothed rim full height. Parts of teeth with full height are arranged on the side of shaft on which gear wheel is installed.

SUBSTANCE: invention relates to wheel drive unit for connection to aircraft landing gear. Wheel drive unit comprises a drive motor, an installation component configured to be installed on a supporting component, a connection component fixed detachably to installation component. Connection component maintains drive motor torque. Wheel drive unit without installation component is configured for dismantling from aircraft landing gear during disconnection of attachment with installation component. Unit also includes a detachable connection for connecting a pair of sections of electric line and/or fluid line. First part of detachable connection is installed on installation component, and second part at connection component, so that dismantling of wheel drive unit from aircraft landing gear also disconnects second part of detachable connection from first part.

SUBSTANCE: invention relates to heat engineering and can be used for decentralised heat supply facilities of low power using solar energy. Obtaining heat, sufficient for use in heating systems with increasing thermodynamic efficiency of system and provide consumers with heat energy from renewable energy sources,is enabled due to that heating device for buildings with ventilated facade includes ventilated facade 1 with upper 2 and lower 3 vents mounted on wall 7 by bloody 6 building heat pump 4, heat exchanger 5 which is placed in upper vent hole and heating system consisting of heating circuit 8 and heater 9.

EFFECT: use of invention in comparison with existing devices of similar purpose will increase temperature of coolant supplied to consumer, and to eliminate noise and vibration caused by heating device.

SUBSTANCE: invention relates to merchandisers, such as refrigeration cabinets with function of vending machine, and aims at increasing functional capabilities of device. Disclosed is a merchandiser, comprising: compartment with controlled temperature accommodating at least one product with controlled temperature; loading system connected with compartment with controlled temperature, configured to receive product and identification of permitted product; a window for rejected products connected with loading system; and module for sales connected with compartment with controlled temperature; loading system can direct product in a window for rejected products, if product is not identified by loading system as permitted product; module for sales is configured to output a product with controlled temperature, identified by loading system, if product is identified by loading system as permitted product.

SUBSTANCE: disclosed is a machine for making bags or sacks, comprising input, drum, and output sections. Drum section has at least one seal bar on a drum. Said sections are mounted to side frames, that are single metal plates. Said frames are not coated after being formed and/or are comprised of at least one of galvanized steel, galvannealed steel, stainless steel or aluminium. Drum is comprised of first and second plates, and opposing third and fourth plates. First plate is rotatable with respect to second plate, and third plate is rotatable with respect to fourth plate. Distance from seal bars to centre of drum is responsive to rotation of plates. First plate has a plurality of non-radial grooves, and second plate has a plurality of radial slots, with fixtures in slots and grooves. Fixtures are connected to seal bars. Non-radial grooves are curved and/or spiraled. Plates are comprised of zinc-plated steel and/or are discs. Winder includes a rotatable turret with a centre and surface wind position, and a centre wind only position. When one spindle is in centre and surface wind position, other spindle is in centre wind only position. Push off palm is mounted in a push off position.

SUBSTANCE: present invention relates to an air conditioning unit and method of controlling an air conditioner. Air conditioner comprises: a radiator circuit; inverter circuit for operation of a motor to drive compressor; inverter control circuit, which drives inverter circuit, and thermal sensor which detects temperature of ambient air fed into control circuit. Said inverter control circuit includes a control unit for fixed power supply and control unit for fixed power supply performs fixed AC power supply or fixed DC power supply to motor in accordance with ambient air temperature, detected thermal sensor. Ambient air temperature is divided into three temperature ranges of first preset temperature and second preset temperature lower than first set temperature, when temperature of ambient air is equal to or lower than second set temperature, heating is performed by fixed DC power supply, and when ambient air temperature higher than second set temperature and is equal to or lower than first set temperature, heating is performed by fixed AC power supply.

EFFECT: designing an air conditioning unit of low cost and low power consumption without increasing size of conditioner, thus providing operability of air conditioner, when it is installed in low-temperature environment, in which temperature falls below guaranteed minimum temperature of electronic component.

SUBSTANCE: method of receiving radio waves includes converting electromagnetic radiation into electric current. At that, to increase intensity of electric field in place of receiving antenna is placed, in which active elements are made from thin metal band double sharpened on two edges.

SUBSTANCE: invention relates to passive filtration system for the fuel loading zone having a pool of spent fuel in nuclear reactor. Passive filtration system reduces release of particles into atmosphere, such as radioactive particles formed in case of boiling of pool of spent fuel. Passive filtration system comprises discharge channel, ventilation mechanism located between the zone of fuel loading and discharge channel. Ventilation mechanism is configured to release the mix of steam and air from the fuel loading zone in the discharge channel. Mixture of water vapor and air contains particles. Passive filtration system additionally contains air filtration unit arranged in discharge channel, and this unit has at least one passive filter. Mixture of water vapor and air is pumped through at least one passive filter due to pressure difference created in the fuel loading zone.

SUBSTANCE: use: in electric power engineering. Method is implemented by that electric power is generated by a diesel generator unit, storage batteries are charged from the diesel generator unit, the required level of charge is controlled by a central controller, performed is receiving/transmitting by means of the central controller control signals from the unit of operation of the diesel generator unit and the storage battery on the remote control unit. Generated is electric energy by means of an additional alternative power sources, particularly, at least one wind generator with a unit of operation and at least one solar panel with a unit of operation. Perform are different power plant control algorithms depending on a mode of operation of each of the units of operation. Residual energy is accumulated in the unit of storage batteries, then it is used in case if power of the sources of energy from the unit of operation of the wind generator and the unit of operation of the solar panel is less than the power of the sources of consumers of the output networks of load. DC voltage from the unit of operation of the wind generator and the unit of operation of the solar panel through a low-voltage bus is directed into a unit of operation of inverters, which converts it into AC voltage for the output load networks, herewith the electric power plant, if necessary, is connected to external networks via an external networks connection device. By means of the central controller chosen is an optimal mode of operation at minimum costs by collecting information on all units operation, by analyzing information and testing equipment for correctness of operation, herewith after analysis and testing predicted is occurrence of emergency situations and a warning the operator is generated.

EFFECT: provision of independent uninterrupted supply of the consumer.

SUBSTANCE: invention relates to electrical engineering. Method of making a magnetic tunnel junction suitable for a magnetic random access memory (MRAM) cell and comprising a first ferromagnetic layer, a tunnel barrier layer, and a second ferromagnetic layer comprises: forming a first ferromagnetic layer; forming a tunnel barrier layer; and forming a second ferromagnetic layer; wherein said forming tunnel barrier layer (22) comprises depositing a layer of metallic Mg; and oxidising deposited layer of metallic Mg so as to transform metallic Mg into MgO. Step of forming tunnel barrier layer is performed at least twice so that tunnel barrier layer comprises at least two layers of MgO.

EFFECT: technical result consists in reduced defectiveness and high breakdown voltage.

SUBSTANCE: invention relates to electrical engineering for power supply of spacecraft from primary sources of different power. Spacecraft power supply system comprises: Set of solar batteries of direct solar light (1), Set of solar batteries of reflected solar light (7), generating circuit (8), voltage stabilizer (2), charging device (3), discharge device (4), accumulator battery (5), rectifier (9), accumulator battery charging controller (10) and consumers (6). AC voltage from generating loop (8) is converted into DC in unit (9) and transmitted to the first input of the accumulator battery charging controller (10). Constant voltage from solar batteries of reflected solar light (7) is supplied to the second input of accumulator battery charging controller (10). Total voltage of generating loop and solar batteries of reflected solar light from the first output of controller (10) falls on the second input of accumulator battery (5). First input of accumulator battery (5) receives switches control signals (15-21) from the second output of controller, having contacts 1-3, and switches (22-25), having contacts 1-2. Number of controlled switching devices depends on number of accumulators in battery. For charging selected accumulator (11-14) on associated switches their first contacts open to the third and are closed with the second, on associated switches of the first and second contacts are closed. Connected in such a way to the second input of battery accumulator is charged by nominal current to admission commands from the controller (10) for replacement of another accumulator. Consumer (6) receives power from remaining accumulators bypassing the disconnected, from the first output of battery (5).

EFFECT: higher of heat resistance, electrical and mechanical strength of compound is the technical result of the invention; besides, electric insulating compound allows to reduce thickness of insulation with preservation of reliability of product at previous level.

SUBSTANCE: invention relates to wireless communication, particularly to transmission of requests for connection with wireless communication networks. In various embodiments, for example, device comprises processor, determination component executed by processor, designed to determine duration of current transmission interval containing sequence of signal intervals, wherein each signal interval includes many time slots, random selection of one signal interval of sequence and random selection of one time slot of plurality of time slots within selected signal interval, and communication component executed by processor, intended for sending request for connection during selected time slot.

SUBSTANCE: combined electric power plant includes wind turbine, aggregated with power units driven by it through system of mechanical transmissions: heat pump compressor connected hydraulically with underground pool; air compressor connected with its inlet to atmosphere, and output with compressed air accumulator; air compressor connected with its inlet to atmosphere, and output with system of ventilation and conditioning; water pump of drinking water supply connected to input of drinking water, and output with water drive tank; standby electric generator; compressor refrigerator with freezing chamber; water circulation pump of heating system; at least two pumps of pumped storage system, each hydraulically connected with its inlet to bottom level tank, and by output is with upper level liquid tank. Fluid can be water, brine or other antifreeze. Deepest point of bottom of upper reservoir is hydraulically connected to input, and lower reservoir to output of hydraulic turbine installed on floating pontoon on surface of liquid of lower tank and rotating main electric generator, which is connected to facility mains. All compressors and pumps are made in form of volumetric type injectors. Combined electric power plant comprises bank of electric batteries connected with main electric generator through rectifier charging device, and via redundant DC electric generator is to DC converter from bank of electric accumulators to alternating current. Compressors, drinking water feed pump and heating system circulation pump are equipped with duplicating electric drives operating directly from bank of electric batteries.

SUBSTANCE: invention relates to image analysis based automatic exposure compensation on video or image signals supplied to home communication system. Result is achieved by that home communication system comprises door station (4) and at least one home station (1), connected to it via bus (15), wherein camera (5) of door station (4) records image persons who are located in front of door station, analogue or digital image signal (BS) generated by camera (5) image is evaluated using region detector (10), which identifies one or more relevant regions of image, wherein sensor (11) of measured brightness determines quality of exposure of at least one region of interest of image based on results of region detector (10), further, control unit (8) from specified nominal value (SW) and generated and output by sensor (11) of measured actual value of brightness (IW) determines control parameters (SG), which iteratively optimise exposure parameters of camera (5) during image recording.

SUBSTANCE: invention relates to electronic engineering and can be used in electron-beam devices with autoelectronic emission, namely: in the probe devices, screens, raster electron microscopes, as well as in research and analytical units. In small-size autoemissive electronic gun, containing a field emission cathode (1) made of nanostructured carbon material enclosed in dielectric casing (2), including first part (3) and second part (4), modulator and contact electrode (6), a modulator is in form of first shell (7), which is tightly fitted on first part (3) of dielectric cover (2), at that free part (8) of first shell (7) and first free end (9) of field radiating cathode (1) protrude above first end (10) of first part (3) of dielectric cover (2), as contact electrode (6) second shell (11) connected to second part (4) of dielectric cover (2) is used and having electric contact with field radiating cathode (1).

EFFECT: technical effect consists in improved reliability and longer life.

SUBSTANCE: invention relates to power industry. Converting one type of current in the other (DC, AC), and thus binding AC network 1 and DC line 14, 15. Three-phase thyristor bridges 10, 11 operate in rectifier or inverter modes. Transformer of one unit has a shift relative to transformer of the other unit at an angle 30/n=15 electrical degrees. Therefore, 6n times harmonics of rectified voltage of one unit are in anti-phase to harmonics of the other unit and are mutually compensated or considerably weakened, because grounding 16 and extension line 17 have their own inductance. Simultaneously, current harmonics are reduced.

SUBSTANCE: invention relates to extraction of one or more monomers from gas flow (1), which includes following steps: in same first extraction column C1: a) step of extraction by bringing gas flow (1) in extraction column (C1) into contact with organic extraction solvent (2), wherein said extraction solvent (2) absorbs said monomer or monomers, and b) step for distillation or desorption with inert gas in extraction column (C1) by feeding into lower part of column (C1) below point of feeding monomer-containing gas stream (1), inert gas stream (12), wherein stream (3) of liquid containing extraction solvent and monomer or monomers is removed from below column (C1), and stream (4) of exhaust gas is discharged from top of column (C1), further, in second regeneration column C2: c) a step for extracting said monomer or monomers, where said monomer or monomers are separated from extraction solvent by distillation in regeneration column (C2), in which is fed a stream (3) liquid drawn from below column (C1), wherein stream containing concentrated monomer or monomers (5), is removed from top of column (C2), and stream (2) of liquid containing extraction solvent is removed from below column (C2), further, recirculating into upper part of column (C1); wherein monomer or monomers are selected from dienes, vinyl aromatic compounds and isobutene.

EFFECT: use of present invention enables to minimise content of impurities at monomer extraction step.

SUBSTANCE: invention relates to organic chemistry, in particular to novel thiohydantoin derivatives of general formula (I) or pharmaceutically acceptable salts thereof, where Z is selected from CF3, C1-C3 alkoxy and halogen; Y is selected from halogen; W denotes oxygen; R3 and R4 are independently selected from C1-C4 alkyl, or R3 and R4 and a carbon atom, to which they are bonded, form a 3-6-member cycloalkyl ring; A1 denotes phenyl or pyridyl optionally substituted with one halogen; A2 is (CH2)mY1(CH2)nQ, where m and n are integers independently selected from 0-2, and where at least one of m or n is not equal to zero; Q is selected from C(O)NHR″, C(RxRy)C(O)NR″R1″, cyano, C(O)OR″, C(O)NR″R1″ and 5-member heteroaryl containing 2 heteroatoms selected from nitrogen, oxygen and sulphur; and Y1 is selected from a direct bond and -O-; R″ and R1″ are independently selected from hydrogen, C1-C6 alkyl, or NR″R1″ together form a 4-6-member heterocyclic ring additionally containing 0-1 oxygen atoms, where one carbon atom can be optionally substituted with one hydroxyl group; Rx and Ry are independently selected from hydrogen or methyl; or C(RxRy) together form a 3-5-member cyclic alkyl ring. Invention also relates to a pharmaceutical composition and a local pharmaceutical composition based on the thiohydantoin derivative of formula (I).

SUBSTANCE: invention relates to compositions for washing clothes containing thiofenazocarboxylated tone dyes for fabrics and a method of processing textile materials, including such compositions for washing clothes. Described is a method of processing textile material containing polyester and/or nylon, herewith the method includes the steps of: (i) textile material processing with aqueous solution containing auxiliary means for washing clothes and 1 part per billion of up to 500 ppm thiofenazocarboxylated dye; and (ii) washing and drying the textile material, herewith the dye contains a colouring agent, having the structure of Formula I:

,

where R1 and R2 are independently selected from [(CH2CR′HO)x(CH2CR″HO)yQ], C1-12 alkyl, C7-C22 arylalkyl, provided that at least one of R1 and/or R2 represents [(CH2CR′HO)x(CH2CR″HO)yQ], where R′ is selected from a group consisting of H, C1-4 alkyl CH2O(CH2CH2O)zQ; where R″ is selected from a group consisting of H, C1-4 alkyl, CH2O(CH2CH2O)zQ; where 1≤x+y≤50; where y≥1; where z = from 0 to 20 and where Q is selected from a group consisting of H and Y, where Y is such as specified below; provided that the colouring agent contains at least one group Q, which is Y; and where Y is an organic radical described in Formula II:

,

where independently for each group Y, M is H or cation, balancing the charge; m is from 0 to 5; n is from 0 to 5; sum of m+n ranges from 1 to 10; each R8 is independently selected from a group consisting of H and C3-C18 alkenyl, and where at least one group R8 is not H.

EFFECT: provision of tone dye effect, uniform tone during precipitation onto a number of fabrics.

W is O; X is NH, O, SO or SO2; Y denotes a hydrogen atom, halogen atom, C1-6alkyl or C1-6alkoxy, each of A and B independently denotes a hydrogen atom, halogen atom or di(C1-6alkyl)aminomethyl; Z is selected from a group consisting of formulae Z2, Z4, Z28, Z61, Z100, Z113, Z138, Z164, Z168 and Z189 .

SUBSTANCE: invention relates to rod manufacturing method. Disclosed is a rod manufacturing method where a) profile of synthetic material is obtained by extrusion from the first moulding composition of synthetic material, which forms the outer layer and consists at least for 50 wt% of partially crystallic thermoplastic, the synthetic material is selected from a polyamide, partially aromatic polyester, fluoropolymer, polyphenylene sulfide and simple polyarylene ether ketone, b) inside this calibrator this fresh extruded profile is filled with the second moulding composition of synthetic material, and c) obtained new rod is calibrated, offset and cooled, note here that first moulding composition of synthetic material has the following characteristics: melting point of crystallites Tm in accordance with ISO 11357 at least 170 °C; crystallisation temperature Tk in accordance with ISO 11357 maximum by 70 K below Tm and enthalpy of melting ΔH in accordance with ISO 11357 at least 20 J/g. Invention also discloses use options of the obtained rod. Rods can be made with high accuracy in size with respect to the diameter and the straightness, and are suitable as workpieces for production of finished parts by cutting, in particular, for making implants.

EFFECT: technical result is that suggested method allows to manufacture multilayer rods with layers consisting of different materials.

SUBSTANCE: invention relates to a method for producing aqueous solutions of methylglycine-N,N-diacetic acid trialkali metal salts using Strecker synthesis, starting from an aqueous solution of α-alanine by reacting same with formaldehyde and hydrocyanic acid to form α-alanine-N,N-diacetonitrile in a reaction unit and saponifying same with a base to form aqueous solution of corresponding methylglycine-N,N-diacetic acid trialkali metal salt. Method is characterised by that α-alanine is partially neutralised, and addition of formaldehyde and hydrocyanic acid for reacting into α-alanine-N,N-diacetonitrile is controlled such that concentration of free hydrocyanic acid in liquid reaction mixture is limited at all times so that secondary reactions, in particular into formaldehyde cyanohydrin, including subsequent reactions of formaldehyde cyanohydrin, as well as polymerisation of hydrocyanic acid occur only to such an extent that aqueous solution of methylglycine-N,N-diacetic acid trialkali metal salt has content of trialkali metal salt and nitriloacetic acid less than 0.1 wt% with concentration of methylglycine-N,N-diacetic acid trialkali metal salt of 40 wt% per total weight of aqueous solution of methylglycine-N,N-diacetic acid trialkali metal salt. Said addition is performed so that concentration of free hydrogen cyanide in liquid reaction mixture in any moment in time is 10 mol% of added hydrocyanic acid, or so that maximum concentration of free acid in liquid reaction mixture does not exceed 20 mol% of free hydrogen cyanide of amount of added partially neutralised α-alanine.

SUBSTANCE: present invention relates to compounds of formula (I) and based on it composition used in medicine at abnormal cell growth

,

where Y is N or CR6; L1 and L2 are independently selected from a linking of -R6NR7-, -R6OR7-, -R6SR7-, alkyl, C5-6-carbocycle and 5-6-member heterocycle containing 1-2 heteroatoms selected from nitrogen; where L1 and L2 can be connected to any position; W1 is selected from C6-12-aryl, optionally substituted by 1-3 halogens, in case when C6-12-aryl is substituted with only two substitutes, these two substitutes are not placed in para positions; W2 is selected from C6-12-aryl and 5-6-member heteroaryl containing 1-2 heteroatoms selected from nitrogen, optionally substituted by halogen, -OR6, -SR6, -N(R6)R7, alkyl or alkyl substituted by halogen; R1 is selected from a group consisting of hydrogen and halogen; R2 and R3 are selected from hydrogen, halogen and alkyl; and R4 and R5 are independently selected from -OR6 and alkyl; where R6 and R7 are selected from hydrogen, halogen and C1-12-alkyl.

EFFECT: new substances modulating protein kinase activity and applicable for treating oncological diseases, ALK or cMet mediated disorders are suggested, including by EML4-ALK mediated fused protein having at least one mutation selected from L1196M, R1275Q and F1174L.

SUBSTANCE: present invention relates to a lubricant for two-stroke marine engine cylinders having base number value BN determined according to standard ASTM D-2896 greater than or equal to 15 potash milligrams per gram of lubricant, containing the following components: (a) one or more than one main oil lubricant for marine engines, (b) at least one detergent based on alkali or alkali-earth metals, which is a overbased due to salts representing metal carbonates, (c) at least one neutral detergent, (d) one or more than one oil-soluble alkoxylated aliphatic amine, having a value BN determined according to standard ASTM D-2896 from 100 to 600 mg of potash per g, where the percentage by weight of alkoxylated aliphatic amines in relation to total weight of the lubricant is selected so that the contribution to BN supported by each of these compounds, ranges from 2 to 8 milligrams potash per gram of lubricant, and where the contribution to total BN supported by salts, which are a metal carbonates makes 65 % of total values of BN said lubricant for cylinders, measured in accordance with ASTM D2896. Present invention relates to application of lubricant (versions) and to concentrate of additives for producing lubricant.

EFFECT: obtaining a lubricant for cylinders, having improved anti-wear properties and thermal characteristics, at that, limiting formation of deposits in the process of application of low-sulphur oil fuel.