Due to the ability to reactivate expression of hepaCAM and inhibit growth of bladder cancer cells, AZAC may represent an effective treatment for bladder cancer.

The extracellular domain of GlialCAM is necessary for cell junction targeting and for mediating interactions with itself or with MLC1 and ClC-2 (show CLCN2 ELISA Kits).

HepaCAM may prevent the translocation of PKCepsilon (show PRKCE ELISA Kits) from cytosolic to particulate fractions, resulting in the inhibition of 786-0 cell proliferation.

GlialCAM is able to interact with all CLC (show CLC ELISA Kits) channels tested in this study, targeting them to cell junctions and activating them by stabilizing the open configuration of the common gate

Results allow classifying the effect of HEPACAM gene mutations in different subtypes and authors indicate different cellular mechanisms that lead to megalencephalic leukoencephalopathy pathogenesis.

we demonstrate an evolutionary conserved role for MLC1 in regulating glial surface levels of GLIALCAM, and this interrelationship explains why patients with mutations in either gene (MLC1 or GLIALCAM) share the same clinical phenotype.

High expression of hepaCAM is associated with renal carcinoma (show TSC2 ELISA Kits).

analysis of mutations in GLIALCAM in patients with megalencephalic leukoencephalopathy with subcortical cysts [case report]

results suggested that HepaCAM acted as a tumor suppressor in prostate cancer

we demonstrate an evolutionary conserved role for MLC1 in regulating glial surface levels of GLIALCAM, and this interrelationship explains why patients with mutations in either gene (MLC1 or GLIALCAM) share the same clinical phenotype.

Hepatic and Glial Cell Adhesion Molecule (HEPACAM) Antigen Profile

Antigen Summary

The protein encoded by this gene is a single-pass type I membrane protein that localizes to the cytoplasmic side of the cell membrane. The encoded protein acts as a homodimer and is involved in cell motility and cell-matrix interactions. The expression of this gene is downregulated or undetectable in many cancer cell lines, so this may be a tumor suppressor gene.