Migraine

DOSAGE AND ADMINISTRATION

Hypertension

The usual initial dosage of BLOCADREN (timolol) is 10 mg twice a day, whether used alone or added to diuretictherapy. Dosage may be increased or decreased depending on heart rate and blood pressure response. The usual total maintenance dosage is 20-40 mg per day. Increases in dosage to a maximum of 60 mg per day divided into two doses may be necessary. There should be an interval of at least seven days between increases in dosages.

BLOCADREN (timolol) may be used with a thiazide diuretic or with other antihypertensive agents. Patients should be observed carefully during initiation of such concomitant therapy.

Myocardial Infarction

The recommended dosage for long-term prophylactic use in patients who have
survived the acute phase of a myocardial infarction is 10 mg given twice daily
(see CLINICAL PHARMACOLOGY).

Migraine

The usual initial dosage of BLOCADREN (timolol) is 10 mg twice a day. During maintenance therapy the 20 mg daily dosage may be administered as a single dose. Total daily dosage may be increased to a maximum of 30 mg, given in divided doses, or decreased to 10 mg once per day, depending on clinical response and tolerability. If a satisfactory response is not obtained after 6-8 weeks use of the maximum daily dosage, therapy with BLOCADREN (timolol) should be discontinued.

HOW SUPPLIED

No. 3343 — Tablets BLOCADREN (timolol) , 5 mg, are light blue, round, compressed tablets,
with code MSD 59 on one side and BLOCADREN (timolol) on the other. They are supplied as
follows:

NDC 0006-0059-68 bottles of 100.

No. 3344 — Tablets BLOCADREN (timolol) , 10 mg, are light blue, round, scored, compressed
tablets, with code MSD 136 on one side and BLOCADREN (timolol) on the other. They are
supplied as follows:

NDC 0006-0136-68 bottles of 100

No. 3371 — Tablets BLOCADREN (timolol) , 20 mg, are light blue, capsule shaped, scored,
compressed tablets, with code MSD 437 on one side and BLOCADREN (timolol) on the other.
They are supplied as follows: