From OMIM, it can be found that age-related macular degeneration is a disorder that arises due to many factors, genetics being only one. If this individual is heterozygous for the allele, then the risk to him or her of this disease is not appreciable, but having children homozygous for the allele would obviously be the remaining concern. If the individual is homozygous, then this higher genetic risk suggests that environmental risk factors should be avoided if possible; these include avoiding smoking, and monitoring diet and cholesterol levels.

From OMIM, it can be found that age-related macular degeneration is a disorder that arises due to many factors, genetics being only one. If this individual is heterozygous for the allele, then the risk to him or her of this disease is not appreciable, but having children homozygous for the allele would obviously be the remaining concern. If the individual is homozygous, then this higher genetic risk suggests that environmental risk factors should be avoided if possible; these include avoiding smoking, and monitoring diet and cholesterol levels.

Conclusion -- this sequence we have obtained is on chromosome 10, and there is one SNP apparent.

Second step:
Examine the genome browser to find where exactly this is to help formulate the query in the next step. Result: 10q25, bases 124210300 to 124210800.

Third step:
Look up SNPs at Entrez SNP based on genome browser information, to find the relevant SNPs and compare to the sequence we currently have (query: "10[CHR] AND 124210300:124210800[CHRPOS]")
Two exist:

Fourth step:
For the first SNP, we have A where the reference sequence has G. For the second SNP (which is on the minus strand), we have T as the complement, in agreement with the reference. Search OMIM to find out more about these loci and the implications of having these alleles (queries: "rs11200638" and "rs2672598")

Conclusions --
Homozygosity for the A allele in the case of the first SNP results in a tenfold increased risk of wet (neovascular) age-related macular degeneration.
No information is available for the other locus.

Last step and physician's advice:
From OMIM, it can be found that age-related macular degeneration is a disorder that arises due to many factors, genetics being only one. If this individual is heterozygous for the allele, then the risk to him or her of this disease is not appreciable, but having children homozygous for the allele would obviously be the remaining concern. If the individual is homozygous, then this higher genetic risk suggests that environmental risk factors should be avoided if possible; these include avoiding smoking, and monitoring diet and cholesterol levels.