list the major limitations of endoscopic biopsies in the diagnosis and grading of BE dysplasia.

correlate the objective measurement of nuclear characteristics by quantitative digital pathology with the different class diagnosis of BE.

discuss the role of quantitative digital pathology in predicting the concomitant presence of high-grade dysplasia or carcinoma when a diagnosis of low-grade dysplasia is made based on routine H&E histopathology.