Harry Kane's injury couldn't have come at a worse time for Tottenham. Alejandro Moreno questions whether Spurs can cope without their star striker.

David De Gea's 11 saves helped Ole Gunnar Solskjaer become the first Man United manager to win his first six matches with a huge win at Tottenham.

Tottenham striker Harry Kane's ankle injury that will sideline him until March was tough to take but has not affected the club's January transfer window plans, manager Mauricio Pochettino told Sky Sports on Wednesday.

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But France midfielder Moussa Sissoko, who pulled up with a groin injury just before half-time in the United defeat, should be fit for the Carabao Cup semifinal second leg at Chelsea next Thursday. Spurs lead 1-0 from the first game at Wembley.

Pochettino said it was "tough" to be without "one of the best strikers in the world" for the next six weeks, but added that it could be an opportunity for the academy players.

"It didn't change [the club's approach to the January window] all that happened with Harry," said the Argentine.

"Son we knew was involved in the Asian Cup for a few weeks. We were always open to improve with Harry in condition or not, but at the same time we know it is going to be tough and difficult to add the player that we want.

"It didn't change our mind, I think it's a very good opportunity for players to play more, to step up. I'm sure it's going to be a good opportunity for young players through the academy to show their quality."

Pochettino has brought several youngsters through to the first team squad with midfielder Oliver Skipp and Argentine defender Juan Foyth having played this season.

But he is likely to rely on experienced Spanish forward Fernando Llorente as a replacement for Kane, while speedy Brazilian forward Lucas Moura should soon be back from injury.

"We know what it means to have Harry Kane fit and available to play and help the team to win, but we have a squad and [his absence] can't be an excuse," he said.

"In the next game we need to play against Fulham [in the Premier League on Sunday] and the semifinal second leg with Chelsea with the same mentality -- thinking we can beat any team."