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MOLECULAR WEIGHT: 366.41CAS NUMBER: 870483-87-7APPEARANCE: Off-white solidSOLUBILITY: DMSO (40 mg/ml)PURITY: 99% by HPLCSTORAGE: Store at -20 ℃DESCRIPTION: A small-molecule, ATP-competitive inhibitor of cFMS kinase; at 60 nM it inhibits human cFMS kinase completely in vitro and was inactive against 26 other kinases. GW2580 also inhibits lipopolysaccharide (LPS)-induced TNF production in mice, but not LPS-induced TNF production in freshly isolated human monocytes and mouse macrophages in vitro.HANDLING: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.