What I am trying to get ideas on how a polypeptide can be made in an aqueous system, since polypeptide are polyamides. Keeping in mind that there were amino acids at the earth formation and water was in abundance . My point to make amides you have to remove a molecule of water .
There was a post on ancient enzyme " Uzime "

Carter, who has been an expert in ancient biochemistry for four decades, took a different approach. His experiments are deeply embedded in consensus biology.

Our genetic code is translated by two super-families of modern-day enzymes. Carter's research team created and superimposed digital three-dimensional versions of the two super-families to see how their structures aligned. Carter found that all the enzymes have virtually identical cores that can be extracted to produce "molecular fossils" he calls Urzymes -- Ur meaning earliest or original. The other parts, he said, are variations that were introduced later, as evolution unfolded.

These two Urzymes are as close as scientists have gotten to the actual ancient enzymes that would have populated Earth billions of years ago.

"Once we identified the core part of the enzyme, we cloned it and expressed it," Carter said. "Then we wanted to see if we could stabilize it and determine if it had any biochemical activity." They could and it did.

Both Urzymes are very good at accelerating the two reactions necessary to translate the genetic code.

"Our results suggest that there were very active protein enzymes very early in the generation of life, before there were organisms," Carter said. "And those enzymes were very much like the Urzymes we've made."

The finding also suggests that Urzymes evolved from even simpler ancestors -- tiny proteins called peptides. And over time those peptides co-evolved with RNA to give rise to more complex life forms.

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First, you have to understand that when you mix acid dissociation constant (K a ) with a heliocondiometric analoid, such as oxygen or carbon dioxide, the diocletium tabassaloid doesn't bode well in the end!