Fusion

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Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:query proteins and first shell of interactors

white nodes:second shell of interactors

Node Content

empty nodes:proteins of unknown 3D structure

filled nodes:some 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

dpaB

Dipicolinic acid synthetase, B subunit (193 aa)

Predicted Functional Partners:

BACCAP_00257

Dipicolinate synthase subunit A (256 aa)

0.965

BACCAP_00252

Uncharacterized protein (45 aa)

0.859

dut

Deoxyuridine 5’-triphosphate nucleotidohydrolase ; This enzyme is involved in nucleotide metabolism- it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (149 aa)

a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1

node2

node1 accession

node2 accession

node1 annotation

node2 annotation

score

BACCAP_00252

dpaB

BACCAP_00252

BACCAP_00251

Uncharacterized protein

Dipicolinic acid synthetase, B subunit

0.859

BACCAP_00257

dpaB

BACCAP_00257

BACCAP_00251

Dipicolinate synthase subunit A

Dipicolinic acid synthetase, B subunit

0.965

BACCAP_00257

spoIVB

BACCAP_00257

BACCAP_01067

Dipicolinate synthase subunit A

SpoIVB peptidase

0.442

BACCAP_00257

spoVAC

BACCAP_00257

BACCAP_03099

Dipicolinate synthase subunit A

Stage V sporulation protein AC

0.584

BACCAP_03091

dpaB

BACCAP_03091

BACCAP_00251

Aldehyde-alcohol dehydrogenase

Dipicolinic acid synthetase, B subunit

0.676

BACCAP_03876

coaE

BACCAP_03876

BACCAP_03893

Pantothenic acid kinase ; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis

Dephospho-CoA kinase

0.456

BACCAP_03876

dpaB

BACCAP_03876

BACCAP_00251

Pantothenic acid kinase ; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis

Dipicolinic acid synthetase, B subunit

0.776

BACCAP_04016

coaE

BACCAP_04016

BACCAP_03893

Pantothenic acid kinase ; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis

Dephospho-CoA kinase

0.456

BACCAP_04016

dpaB

BACCAP_04016

BACCAP_00251

Pantothenic acid kinase ; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis

Dipicolinic acid synthetase, B subunit

0.776

coaE

BACCAP_03876

BACCAP_03893

BACCAP_03876

Dephospho-CoA kinase

Pantothenic acid kinase ; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis

0.456

coaE

BACCAP_04016

BACCAP_03893

BACCAP_04016

Dephospho-CoA kinase

Pantothenic acid kinase ; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis

0.456

coaE

dpaB

BACCAP_03893

BACCAP_00251

Dephospho-CoA kinase

Dipicolinic acid synthetase, B subunit

0.760

dpaB

BACCAP_00252

BACCAP_00251

BACCAP_00252

Dipicolinic acid synthetase, B subunit

Uncharacterized protein

0.859

dpaB

BACCAP_00257

BACCAP_00251

BACCAP_00257

Dipicolinic acid synthetase, B subunit

Dipicolinate synthase subunit A

0.965

dpaB

BACCAP_03091

BACCAP_00251

BACCAP_03091

Dipicolinic acid synthetase, B subunit

Aldehyde-alcohol dehydrogenase

0.676

dpaB

BACCAP_03876

BACCAP_00251

BACCAP_03876

Dipicolinic acid synthetase, B subunit

Pantothenic acid kinase ; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis

0.776

dpaB

BACCAP_04016

BACCAP_00251

BACCAP_04016

Dipicolinic acid synthetase, B subunit

Pantothenic acid kinase ; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis

0.776

dpaB

coaE

BACCAP_00251

BACCAP_03893

Dipicolinic acid synthetase, B subunit

Dephospho-CoA kinase

0.760

dpaB

dut

BACCAP_00251

BACCAP_00678

Dipicolinic acid synthetase, B subunit

Deoxyuridine 5’-triphosphate nucleotidohydrolase ; This enzyme is involved in nucleotide metabolism- it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA

0.789

dpaB

spoIVB

BACCAP_00251

BACCAP_01067

Dipicolinic acid synthetase, B subunit

SpoIVB peptidase

0.716

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Network Stats

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Functional enrichments in your networkNote: some enrichments may be expected here (why?)

Enrichment analysis is still ongoing, please wait ...

Statistical background

For the above enrichment analysis, the following statistical background is assumed: