Anyone ever have a helpful response to Moclobemide ('newer' MAOI)?I live with chronic depression and an apparent anxiety disorder, most recently diagnosed as actually a Trauma Disorder... Whatever -- keeps me from going out, facing people. Have tried every antidepressant out there, as well as stuff like Ritalin/Lyrica (BAD reaction) -- just FYI.Haven't read much online to encourage me to try it (and put my body through any more -- I have Chemical Sensitivities, too). about to give up the med route (again), but my doc is really pushing this one.

I'm really in a negative 'space', so please -- only positive responses to this antidepressant would be most appreciated!

Yes, I've read relatively positive stuff on all the medical, drug, and info sites (like Wiki..), but not so much as far as it being of any great help on other patient forums that come up through Google searches. (Most said they had little to no response, as compared to regular MAOIs, but which have a lot of side effects.)

Thanks for caring, though.Fibromyalgia, CFS, possible CSS, Chronic Depression/Anxiety Disorder, Agoraphobia, PTSD ... But they're all connected & I'm working on them all - I will prevail!

CSS is Chemical Sensitivities Syndrome.And as you also have fibromyalgia, I'm sure you're aware there are a whole slew of syndromes and disorders all connected that fall under the umbrella group: Myalgic Encephalomyelitis (M.E.). I obtained a wealth of knowledge through a wonderful M.D., Dr. Alison Bested, who runs an Integrative Medicine practice and co-wrote the book: "Hope & Help for Chronic Fatigue Syndrome and Fibromyalgia". Best, most balanced source of information on these illnesses I've ever come across and which includes theoretical causes, current scientific study, symptoms (of each disorder), and treatments (listed under both 'western' Medicine and Alternative). My, but I do go on!

Stay well,CailinFibromyalgia, CFS, possible CSS, Chronic Depression/Anxiety Disorder, Agoraphobia, PTSD ... But they're all connected & I'm working on them all - I will prevail!

Thanks for the info. I am sensitive to a lot of things. Sensitive skin mostly. I wrote down the title to the book, I will check it out. There was a dr. Armond that wrote a book which was good. But he in the end said the cure to it was going on a guaifinisen diet. And that means to avoid silacylates which is in almost everything on the planet. But a lot of his book made a lot of sense. I am anxious to read this one. Thank you.

Wow, I'd never even heard of this Guaifinisen Diet, so I Googled it and did find a Dr. Dantini in Ormond, Florida, who I think wrote the book. It does sound promising, and I do lean in favour of some kind of viral cause. But, like you, if a diet is sooooo restrictive, unless you have a personal chef, it's pretty difficult! I find with a lot of these diets, too, that they include foods that I have intolerances to (IBS!!) and/or are inflammatory. It all just becomes too overwhelming and exhausting when you're just doing your best to get out of bed and function on some level every day! The other red flag for me is a doctor's site that personally sell send-away tests, their own additional supplements, etc., etc. ...I guess that's what impressed me with Dr. Bested practice -- it's totally professional; you're simply provided with the information and decide yourself what direction you take, whether it's strictly 'western' medical (which is part of Universal Healthcare in Canada) or more alternative. In that case NDs work in her practice (but are paid separately on a sliding scale) and they will supply any tests and sell supplements (not their own) that they have researched stringently and also offer at a cheaper price for low-income patients. Her book is to reach people who are more housebound. She's really in the business of helping people in pain -- no profit here. (It's the most modest strip mall office, and I've often seen her mopping the floors herself near closing time!) I'm telling you, they broke the mould with this lady. It should be a medical model!All that said, I believe everyone's an individual and, since they STILL don't know what the true cause is yet, why not try everything that's out there? Hopefully, something will eventually stick. ..A girlfriend of mine went the totally natural route, cutting out all the "bad" whites (sugar, flour, dairy), she exercises, uses infrared saunas, etc., and swears she hasn't had a flare-up in years! ...But I'm no martyr, so the more balanced approach is more my style.One day I might even try organizing a walking group for people with chronic pain issues -- it can get lonely out there!Anyway, Karen, I do hope Dr. Bested's book is of some help, though you could probably write your own, I'm sure!

Slainte!'CailinFibromyalgia, CFS, possible CSS, Chronic Depression/Anxiety Disorder, Agoraphobia, PTSD ... But they're all connected & I'm working on them all - I will prevail!

I think we could all write a book either about fibromyalgia or depression. I am doing pretty good with both right now. I do have pain, and my world isn't perfect by no means, but I am happy for the most part. I can't complain. But it wasn't always this way. I spent close to two years in bed. It was terrible. I could barely walk. I thought I was dying. But I used medications for help. I got on adderall for fatigue and pain meds for the chronic pain. I also take antidepressants, anti anxiety and a mood stabilizer. It took years to find what worked for me. And as you said, we are all different. And different things work for different people. I do plan to look for the book. I figured I would google it and most likely find it on amazon. Anything that helps. I use to be a member of the fibromyalgia network newsletter. It is expensive though. But they keep you up to date on everything. And have some good stuff there. If you get a chance to read one, do...

I hope you have a good evening. It is my bedtime. So I am going to scoot.

Like so many who learn to live with chronic illnesses, you obviously have incredible spirit and will. It's amazing to me how many of us are out there. I just hope a major breakthrough is made, sometime soon, as to what the root cause actually is. Right now, all we can do is treat the symptoms, as you seem to have finally been able to after many years of trial and error. -- On that note, I'd just like to ask one more question... You mention taking Adderall for fatigue. I've just finished an unsuccessful trial of Ritalin for fatigue. Did you ever try it before the Adderall? (I know Adderall works on two brain receptors, as opposed to just the one with Ritalin.) I'm trying to decide whether to go that route, at this point, or try another.

(Think I'll start a new, less restrictive, thread for the Moclobemide, too. This one kind of got lost in a personal discussion!)

Thanks,

CailinFibromyalgia, CFS, possible CSS, Chronic Depression/Anxiety Disorder, Agoraphobia, PTSD ... But they're all connected & I'm working on them all - I will prevail!

I tried concerta before, which is ritalin in a time release form. It wasn't consistant for me. Some days it worked and some days it didn't. So then I tried adderall. I take 30mg adderall xr every morning. It works well for me. They will probably start you out on a lower dose, what milligram of ritallin did you try? Was it regular ritalin?

Sorry for the delay in getting back to you, Karen... I tried both regular release Ritalin and Concerta. My doc pushed both up to their highest dosages (Ritaling/60mg and Concerta 72mg), before we gave up. Out of a month, I had two good response days, but even they didn't last more than about an hour. it's been so disappointing, because I hadn't felt that "normal", alert, focused, and motivated in years. But the worst part was the crash I would experience a couple of hours after a dose -- lots of physical discomfort and intense 'rebound' depression. That's why I was wondering about the Adderall -- that maybe it would work a little longer and more smoothly? My dr is open to trying it. I'm just a little cautious because of the rebound depression I experienced with the Ritalin -- I don't want to go through that again. But if that doesn't appear to be a side effect of the Adderall, I'd definitely be open to giving it a try.

Hope you're doing well and thanks for all the feedback!

CailinFibromyalgia, CFS, possible CSS, Chronic Depression/Anxiety Disorder, Agoraphobia, PTSD ... But they're all connected & I'm working on them all - I will prevail!

I find that the adderall xr works well for me. The only problem that I have is on the days I wake up early due to pain. If I take my adderall too early, I get tired early in the evening. But I have taken adderall ir (imediate release) but I needed two doses a day. The xr is only one. I tried vyvanse, but it didn't work well for me, so I highly recommend you try the adderall. I sure do hope that it helps you. If I didn't take it I would be in bed. All day and night. I slept for almost two years when I first got fibromyalgia. It was horrible. It took that long to get diagnosed and treated properly. I am sure you understand that.

Your feedback has been really helpful. I am absolutely going to tell my dr I'd like to give the Adderall a try, next week.

I know exactly what you're talking about re 'sleeping your life away' for two years! I'm in that place, right now, so maybe, just maybe, it can give me some of my life back ... So much in life yet to do!I'm happy to hear it has helped you so much...

BTW: Think I figured out why no one here has tried Moclobemide -- It appears it hasn't been approved for use in the U.S.

Anyway, have a nice Memorial Day weekend down there!Bye for now,

CailinFibromyalgia, CFS, possible CSS, Chronic Depression/Anxiety Disorder, Agoraphobia, PTSD ... But they're all connected & I'm working on them all - I will prevail!

I could be very wrong, but I think it was approved. But I think it is really new here. Like I say, I could be wrong. But it seemed like it said that it was researched for a very long time. There is so much that is approved in other places but not here. I think a lot of it could be because of drug companies wanting to make money off of the drugs that they do have, and then when the new medication comes out, they make all the money that they can off of that. So much is controlled by money. I could be wrong about that one too. But that is my guess.

There were these new pain patches that I wanted to try. They are called Butrans. I got a prescription,with a free trial offer for a month. My insurance first wanted priorauthorization. I got that. Then they said that there was a questionaire that I had to do. They wanted me to try fentynal patch, morphine and methadone before I could get the butrans patch. And that isn't even a class two drug. I was so disappointed. But this had been approved in other countries for a long time. Come to find out my copay would of been about 100.00 for the medication if I would of been able to get it. I just can't understand why they would want me to take all of these different strong narcotics before they would approve something that isn't nearly as strong, and not even in the same class. Oh well.

I think you are going to like the adderall. I don't know what milligram he will start you out at. But if it is under 20, I would not be upset if it doesn't work. They kind of like to start you out slow and work you up gradually. I have been at 30mg for a few years now and it works good for me. And I like the controlled release because it works so long. With the other, I was taking one in the morning (30mg ir) and one in the afternoon. And that worked good. But I like only having to take one a day because I often forget my afternoon doses. Then I want to go to bed at about 7:00 and it is too late to take it because I would be up all night.

Anyhow, yes, ask about it and I hope he starts you out at a helpful dose. I started out at 15mg in the morning and then again in the afternoon with the imediate release. But it wasn't strong enough, though I did notice it.

I agree totally with you in regards to drug companies. Trust me, they and insurance companies are causing a lot of problems here, too. A psychiatrist even told me that with the introduction of SSRIs in the '90s, the whole Canadian model of Mental Health treatment began to change -- government insurance stopped covering Psychologists, forcing the first line of treatment over to medication. Our once wonderful Universal Healthcare is no longer as ideal as Michael Moore would have you believe -- not any more, anyway! E.g., you wouldn't believe what I had to go through to get Botox approved by my private insurance for treatment of a Tardive Dystonia I developed (my eyes clamped shut) as a side effect of one of my meds. (A lot of GPs apparently now do cosmetic side businesses, now!) Anyway, drug & insurance companies need to be reigned in fast, in my opinion!

I started the Adderall XR, yesterday, and we used a conversion chart (from Concerta to Adderall XR) to decide on the starting dose, which was 40mgs! But she suggested 30mg to begin. Unfortunately, so far I've had zero response, and in fact actually feel very weepy a couple of hours after I take it! And the agitation last night!! Waiting to hear from her today to see what she suggests. ...I dunno, could be that we started too high ... or too low! ... or that because it works differently than Concerta, my brain doesn't like something it does... Pretty fed up, though. Anyway, really nice chatting with you from time to time -- I've become pretty isolated over the years.

Hope you're having a good day, today! ...It's a comfortable 21〫Celsius (approx. 70〫F) here in T.O...

TC,CailinFibromyalgia, CFS, possible MCS, Chronic Depression/Anxiety Disorder, Agoraphobia, PTSD ... But they're all connected & I'm working on them all - I will prevail!

Did I tell you I ordered that book??? I hope to get it soon. I got the yellow one too. I can't wait to start reading it.

I am so sorry that the adderall isn't boosting your energy... Are you by any chance adhd? If you are, it wont give you a stimulant feeling. I was so hoping that it would work for you. There still is vyvanse. That might work for you. And provigil, nuvigil too. I imagine that you are very frustrated at this point. I would be. I was on the vyvanse because it didn't do anything for me other than keep me awake some. The adderall gives me energy. I hope that you find what works for you. I can't remember why you wanted off of the concerta.

I kept myself isolated from people for a long time. Life became easier that way. But now I do have some friends. I get out and do things some. Not a lot. All that is around here is bars and I don't like them. Sometimes I go down to the river with friends. I spend a lot of time with my dog. She is my best friend. But she is a brat sometimes. Still puppyish. She is a german shepherd. Her name is Jasmine. She is really pretty, small for a shepherd. Full of crap sometimes. lol...

I hope that your day gets better. I like posting on here, and talking to people. I have made a lot of friends. It has been nice.

Yes, Karen, you did tell me you ordered the book! And only $4! (I hope it's not used and marked up.) I hope you find it as well laid out and informative as I did. (I gave it to a couple of people as gifts, and they found it really helpful. ...And, yes, a number of old friends and my sisters all have fibro! -- Has to make you wonder if there isn't an environmental component...) I might buy the new edition, myself, to see if she's added any important updated information.

Just spoke with my dr, and she convinced me to give the Adderall XR a few more days with increases to give it a fair shot. Everyone metabolizes so differently, so dosing can apparently vary quite a bit. ...And BTW, no, I'm definitely not ADHD!

It's great that you've been able to get out and about with some friends. Just the distraction of the activity and feeling a sense of belonging can make a big difference in how you feel, both physically & mentally. ...And your dog, Jasmine -- pets are amazing motivators & company! I love the bratty thing! -- shows she has mischievous spirit and is quite smart! I don't live far from what we here call The Beach (a town-like area on Lake Ontario) in Toronto -- There are a huge number of dog lovers who hang out down there in the off-leash section. Sometimes I would go down there just to watch the dogs play with each other -- there's such a simple joy in them that never fails to give me a lift! The Labs are priceless: see stick, see stick thrown into water, dive in water to get stick, bring stick back... rinse & repeat, repeat, repeat...! ****!

At heart, though, I'm a kitty-person. Had a couple of sisters for 17 yrs, and you talk about bratty?? But they were great company; miss them a lot. Hope to get another down the road sometime. In the meantime, the neighbourhood cats, Butter, Jango, Raggs & Muffin (Ragamuffin, get it?) come for visits.

Well, have to remember to go eat some dinner, so I'm off for now.I'll keep you posted on my Adderall XR 'progress', and let me know when you get the book.

TC,CailinFibromyalgia, CFS, possible MCS, Chronic Depression/Anxiety Disorder, Agoraphobia, PTSD ... But they're all connected & I'm working on them all - I will prevail!

P.P.S 'Anagram' isn't the word I was looking for!! But too tired, now, and I know you know what I meant!Fibromyalgia, CFS, possible MCS, Chronic Depression/Anxiety Disorder, Agoraphobia, PTSD ... But they're all connected & I'm working on them all - I will prevail!

It sounds interesting with the kitties. I like cats too. My girlfriend's cat had one kitten, a calico. The mama was black and a small cat. Well we think it is a male. Which are rare, and they say that male calico's can't reproduce. Which is strange. But I just thought that I would tell you about it.

I have had a good day, didn't get anything of much done really. It was nice talking to you. I hope that you have a good evening.

So far all the used books that I have gotten at Amazon have been in good condition. So I hope that this one is too.