Chick Embryo Development
This animation was commissioned by the Poultry Cooperative Research Centre (Poultry CRC) for use in their outreach and
educational initiatives across Australia. It details the 21-day development of a chick embryo within the egg, with an emphasis
on a number of areas in the national science curriculum, from teaching life cycles to the complexities of comparative embryology.
Created for
Australian Poultry CRC

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Leap Motion Controller
The Leap Motion Controller allows people to interact with computers using natural hand gestures.
No keyboard or mouse is required, making this technology ideally suited to exhibition spaces with high user turnover.
As a Leap Motion developer, AXS studio is enabling our clients to engage their audiences more directly and in a way that sets them apart from the
competition on crowded exhibit floors.

Stellaris PC
We developed this interactive presentation to allow stakeholders in ophthalmic surgery to explore the innovative
features of the Stellaris PC surgical platform. Through our user-centered design approach, we employed rich graphics
to invite exploration of key components and their benefits in an intuitive touch-screen interface.
Created for
Bausch + Lomb

Understanding Brain Injury iBook
This e-book fills a gap in the resources available for patients with brain injury and their families: an illustrated,
interactive guide to key terms and concepts related to brain function, injury, and treatment. Users can explore
illustrations interactively and browse the material in a non-linear fashion, with imagery that respects the sensitive
nature of the subject and our audience.Created forFlorida Institute for Neurological Rehabilitation (FINR)

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The Antithrombotic Conundrum
The paradox that thrombosis can be simultaneously dangerous and necessary has proven difficult to convey to an audience of biotechnology investors.
During procedures such as angioplasty, blood clotting must be controlled with anticoagulants to prevent ischemia. However, when the procedure is complete,
clotting is vital to prevent bleeding, and is an essential part of the healing process.Created for
Regado Biosciences

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Antiproliferative Effects of mTOR Inhibition
Inhibition of the mTOR pathway with everolimus is an emerging therapy for complications of organ transplantation,
most notably graft rejection. This animation introduces health care professionals to the broader benefits of this
treatment, with special focus on curbing both fibrosis and cancer growth in the liver.Created for
Novartis br>
BioScience Communications

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Biotrue ONEday lenses
Biotrue ONEday lenses provide improved moisture-retention, clarity and comfort. Created for eye care professionals,
this animation explores the science and technology behind the bio-inspired moisture-retaining properties of the
HyperGel lens material: water content similar to the human cornea and a moisture-retaining lipid barrier that mimics
the natural tear film. This animation won an Award of Excellence from the Association of Medical Illustrators in 2013.Created for
Bausch + Lomb
BioScience Communications

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Transdermal Analgesic MOA
This animation describes the mechanism of action of a transdermally-administered analgesic — specifically,
how it affects particular opioid receptors responsible for initiating a pharmacological response. Created for
Abelson Taylor

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Kalydeco
Cystic fibrosis (CF) is an inherited chronic disease that affects thousands worldwide. KALYDECO is
a new treatment for those patients whose CF results from a certain gene mutation. This concise
one-minute informational video was developed for use in a wide-reaching media campaign. It employs
a friendly, stylized look for wide appeal and compatibility with numerous media applications. Created for
Vertex Pharmaceuticals
BioScience Communications

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Microbiology Lab Animation Series
We created this series of animations for Pearson’s Mastering Microbiology course materials.
Rich in detail, these visualizations show students what’s occurring at cellular and molecular
levels in laboratory staining procedures such as Gram staining, acid fast staining, smear
preparation, PCR, and ELISA. Our custom-built 3D models are based on the most up-to-date molecular
structures and research from the scientific literature.Created for
Pearson Higher Learning

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The Nano Revolution
The Nano Revolution is a three-part television series that explores the future
impact of nanotechnology on our society, environment and health. AXS Studio created
five science animations along with chapter titles in English and French for "Nano and
the Environment", the third episode in the series, which first aired October, 2011. Created forThe Nature of Things with David Suzuki

The HVAD System
HeartWare International is a medical device company developing a family of implantable Left
Ventricular Assist Devices (LVADs) for the treatment of advanced heart failure. This animation
introduces cardiac surgeons and other stakeholders to the components of the HeartWare System and
its key advantages such as its proprietary suspension system (which eliminates wear) and its small
size (which allows minimally-invasive implantation). Created for
HeartWare International

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Inside Kidney Stone Disease
Stone disease affects millions of adults. A kidney stone can be as small as the head of a pin,
but the pain it can produce can be enormous. This animation explains how and why kidney stones
form, major risk factors for development of stone disease and the key to therapy: preventing
recurrence. Created for
Topin and Associates
Mission Pharmacal

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Oral Calcitonin in Osteoarthritis
In this film, we travel deep inside the intricate microarchitecture of living bone to
explore the synergies at work in maintaining healthy joints. The hormone calcitonin is
thought to help maintain normal signaling between the cells that regulate bone turnover.
This in turn helps maintain cartilage and synovium health, as evidenced through reduced
joint space narrowing, pain relief, and joint function. Created for
BioScience Communications
Novartis

ReGenesis
Dr. David Sandström and his team of top scientists at NorBAC investigate questionable
advances in biotechnology. AXS created the series' signature CGI moments that allow
the audience to see and think like a scientist. Created forShaftesbury Films

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IL-1β Regulation in the Inflammatory Response
Inflammation is the complex biological response of cells and tissues to harmful stimuli which can trigger healing, or, if chronic, lead to a host of diseases.
At the cellular level, inflammatory processes are activated by a multiprotein molecular machine called the inflammasome. This animation explains the assembly
of the inflammasome and its role in diseases such as gout.Created for
BioScience Communications
Novartis

The Vital Organs
When Esquire Magazine approached us to illustrate
the article “Vital Organs: Brain, Heart and Balls”
by
A. J. Jacobs, we put our heads and hearts into the
challenge. Vetted for accuracy by medical experts
Dr. David Perlmutter, Dr. Mehmet Oz, and Dr. Harry
Fish, our renderings reveal what every Esquire Man
should know about his vital parts. Created for
Esquire Magazine (December 2009)

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Hidden Switches in the Mind
In the last decade, scientists have uncovered an extensive array of molecular mechanisms
that allow the environment to alter how genes behave without changing the information they
contain. AXS created illustrations depicting how these “epigenetic” changes may contribute
to our susceptibility to addiction and depression. Created for
Scientific American Magazine (December 2011)

Nanodots Used in Cancer Imaging,Diagnosis and Therapy
Advances in nanotechnology research have provided a new set of tools for research and clinical applications.
Changing the size, shape, and composition of a nanoscale particle allows researchers to alter the materials'
optical, magnetic or other properties and potentially custom-design materials for a specific need. AXS created
various illustrations of different “nanodots” for the Chan Research Group. Created for
Chan Research Group (University of Toronto)

A Breath of Fresh Air
Cystic fibrosis is a life-threatening genetic disorder. Though the mutation behind the
disease was discovered in 1989, a cure has eluded researchers. Recently, insights into
how cells regulate their environments have set the stage for new treatment discoveries.
AXS visualized how the CFTR membrane channel is a promising new drug discovery target
for the treatment of cystic fibrosis. Created for
Scientific American Magazine (July 2011)

FINR Atlas of Brain Injury & Anatomy
This interactive 3D atlas was created to help clinicians explain brain anatomy and common brain
injuries to patients and families. Developed as both an iPad/iPhone app and a Flash Website,
it’s available to anyone with an interest in brain anatomy. Rendered in high-definition with
intuitive controls, it provides users with a rich, interactive educational experience. Created forFlorida Institute for Neurologic Rehabilitation (FINR)

Mood Assessment with Animated Characters
Mood Assessment with Animated Characters (MAAC) is an interactive software application that uses animated characters to help psychiatrists evaluate anxiety disorders in children.
Developed with Dr Katharina Manassis for the Hospital for Sick Children in Toronto.Created for
The Hospital for Sick Children (SickKids)

Interactive 3D BrainGenes to Cognition (G2C) Online is a Web-resource for exploring the basis of thinking on many levels —
from genes and cells to behavior and environment. AXS created a 3D interactive atlas of the human brain
as an embedded resource that supports videos and articles in G2C. The atlas is also available as an iOS app. Created for
DNA Learning Centre, Cold Spring Harbor Laboratory