Women who binge drink before becoming pregnant ‘more likely’ to have diabetic babies

Women who binge drink before becoming pregnant 'more likely' to have diabetic babies

Published:06:00Monday 10 April 2017

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Women who binge drink BEFORE they become pregnant can still harm their babies, warns new research.

The study suggests mothers who binge drink before they become pregnant may be more likely to have children with high blood sugar and other changes in glucose function that increase their risk of developing diabetes as adults.

The study of lab rats was led by Professor Dipak Sarkar, director of the endocrine research programme at Rutgers University in the United States.

Principal investigator Prof Sarkar said: “The effects of alcohol use during pregnancy on an unborn child are well known, including possible birth defects and learning and behaviour problems.

“However, it is not known whether a mother’s alcohol use before conception also could have negative effects on her child’s health and disease susceptibility during adulthood,”

For women, binge drinking is defined as the equivalent of four or more drinks in about two hours.

Prof Sarkar and his colleagues conducted the study in rats, whose basic processes of glucose function are similar to those in humans.

For four weeks, they gave female rats a diet containing 6.7 per cent alcohol, which raised their blood alcohol levels to those of binge drinking in humans.

Alcohol was then removed from the rats’ diet, and they were bred three weeks later, equal to several months in humans.

Adult offspring of these rats were compared with the offspring of rats that didn’t receive alcohol before conception.

After the rats’ offspring reached adulthood, the researchers used standard lab techniques to monitor their levels of blood glucose and insulin and two other important hormones, glucagon and leptin.

Glucagon stimulates the liver to convert glycogen into glucose to move to the blood, making blood glucose levels higher. Although the main function of leptin is inhibiting appetite, it also reduces the glucose-stimulated insulin production by the pancreas.

The researchers found that the offspring of rats exposed to alcohol before conception had several signs of abnormal glucose function.