i am a healthcare professional home links site map contact us this site is not intended for us residents. Patient section > what is niemann-pick type c disease? What is niemann-pick type c disease? How common is niemann-pick type c disease? buy cheap viagra online uk What causes niemann-pick type c disease? What are the symptoms of niemann-pick type c disease? viagra men price south africa How is niemann-pick type c disease diagnosed? viagra pills How is niemann-pick type c disease managed? How does niemann-pick type c disease impact patients? viagra uk 24 hour delivery Further information and links glossary what is niemann-pick type c disease? In niemann-pick type c disease (np-c) the normal movement of fatty molecules (lipids) within cells is disrupted. viagra dosage bph Instead of being recycled or reused, these fatty molecules (particularly cholesterol and glycosphingolipids), which play a very important role in the structure and function of all cells, build up in various parts of the body, including the brain, liver and spleen. 1,2 eventually, toxic levels of these fatty molecules are reached, causing cell damage, especially in the brain. 1,3 np-c is an inherited disorder caused by mutations, or changes, in one of two genes (known as npc1 and npc2) that each produce a protein, called the gene product. viagra jelly uk 4 although the function of these gene products is not fully understood they play a very important role in the movement and recycling of fatty molecules within cells. 1,3 when the npc1 or npc2 gene is mutated the gene product does not function properly causing the fatty molecules to become trapped and thus build up in cells. The build up of fatty molecules in the brain damages nerve cells (neurons) causing them to change shape, and grow abnormally. viagra online without prescription canada These changes lead to the characteristic neurological symptoms seen in np-c. 1 the accumulation of fatty molecules also leads to the abnormal enlargement of the liver and/or spleen that often occurs in infants with np-c. 1 references wraith je, imrie j. viagra uk 24 hour delivery Understanding niemann-pick disease type c and its potential treatment. generic viagra canada Uk blackwell publishing, 2007. Walkley su, suzuki k. buy generic viagra online Consequences of npc1 and npc2 loss of function in mammalian neurons. Biochim. viagra uk 24 hour delivery order viagra online Online Coaching Videos ... here now !