Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase ; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (262 aa)

0.989

lpxD

UDP-3-O-acylglucosamine N-acyltransferase ; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (364 aa)

0.985

R2601_24270

3-oxoacyl-(Acyl-carrier-protein) reductase (245 aa)

0.982

R2601_08236

UDP-3-O-acyl-N-acetylglucosamine deacetylase ; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis (286 aa)

0.978

R2601_03613

Short-chain dehydrogenase/reductase SDR (244 aa)

0.951

R2601_25046

Lipid-A-disaccharide synthase ; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (385 aa)

0.944

fabH

Beta-ketoacyl-ACP synthase III ; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and/or straight-chain of fatty acids (323 aa)

0.940

R2601_24265

Malonyl CoA-acyl carrier protein transacylase (313 aa)

0.940

R2601_23750

3-oxoacyl-[acyl-carrier-protein] synthase 2 ; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (418 aa)

a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1

node2

node1 accession

node2 accession

node1 annotation

node2 annotation

score

R2601_03613

R2601_08236

R2601_03613

R2601_08236

Short-chain dehydrogenase/reductase SDR

UDP-3-O-acyl-N-acetylglucosamine deacetylase ; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis

0.579

R2601_03613

R2601_23750

R2601_03613

R2601_23750

Short-chain dehydrogenase/reductase SDR

3-oxoacyl-[acyl-carrier-protein] synthase 2 ; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP

0.915

R2601_03613

R2601_24265

R2601_03613

R2601_24265

Short-chain dehydrogenase/reductase SDR

Malonyl CoA-acyl carrier protein transacylase

0.849

R2601_03613

R2601_24769

R2601_03613

R2601_24769

Short-chain dehydrogenase/reductase SDR

Enoyl-[acyl-carrier-protein] reductase [NADH]

0.580

R2601_03613

fabH

R2601_03613

R2601_26016

Short-chain dehydrogenase/reductase SDR

Beta-ketoacyl-ACP synthase III ; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and/or straight-chain of fatty acids

0.907

R2601_03613

fabZ

R2601_03613

R2601_25061

Short-chain dehydrogenase/reductase SDR

Beta-hydroxyacyl-ACP dehydratase ; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs

0.951

R2601_08236

R2601_03613

R2601_08236

R2601_03613

UDP-3-O-acyl-N-acetylglucosamine deacetylase ; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis

Short-chain dehydrogenase/reductase SDR

0.579

R2601_08236

R2601_24270

R2601_08236

R2601_24270

UDP-3-O-acyl-N-acetylglucosamine deacetylase ; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis

3-oxoacyl-(Acyl-carrier-protein) reductase

0.579

R2601_08236

R2601_24769

R2601_08236

R2601_24769

UDP-3-O-acyl-N-acetylglucosamine deacetylase ; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis

Enoyl-[acyl-carrier-protein] reductase [NADH]

0.625

R2601_08236

R2601_25046

R2601_08236

R2601_25046

UDP-3-O-acyl-N-acetylglucosamine deacetylase ; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis

Lipid-A-disaccharide synthase ; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

0.976

R2601_08236

fabZ

R2601_08236

R2601_25061

UDP-3-O-acyl-N-acetylglucosamine deacetylase ; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis

Beta-hydroxyacyl-ACP dehydratase ; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs

0.978

R2601_08236

lpxA

R2601_08236

R2601_25056

UDP-3-O-acyl-N-acetylglucosamine deacetylase ; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis

Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase ; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

0.999

R2601_08236

lpxD

R2601_08236

R2601_24509

UDP-3-O-acyl-N-acetylglucosamine deacetylase ; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis

UDP-3-O-acylglucosamine N-acyltransferase ; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

0.999

R2601_23750

R2601_03613

R2601_23750

R2601_03613

3-oxoacyl-[acyl-carrier-protein] synthase 2 ; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP

Short-chain dehydrogenase/reductase SDR

0.915

R2601_23750

R2601_24265

R2601_23750

R2601_24265

3-oxoacyl-[acyl-carrier-protein] synthase 2 ; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP

Malonyl CoA-acyl carrier protein transacylase

0.999

R2601_23750

R2601_24270

R2601_23750

R2601_24270

3-oxoacyl-[acyl-carrier-protein] synthase 2 ; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP

3-oxoacyl-(Acyl-carrier-protein) reductase

0.963

R2601_23750

R2601_24769

R2601_23750

R2601_24769

3-oxoacyl-[acyl-carrier-protein] synthase 2 ; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP

Enoyl-[acyl-carrier-protein] reductase [NADH]

0.956

R2601_23750

fabH

R2601_23750

R2601_26016

3-oxoacyl-[acyl-carrier-protein] synthase 2 ; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP

Beta-ketoacyl-ACP synthase III ; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and/or straight-chain of fatty acids

0.996

R2601_23750

fabZ

R2601_23750

R2601_25061

3-oxoacyl-[acyl-carrier-protein] synthase 2 ; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP

Beta-hydroxyacyl-ACP dehydratase ; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs

0.937

R2601_24265

R2601_03613

R2601_24265

R2601_03613

Malonyl CoA-acyl carrier protein transacylase

Short-chain dehydrogenase/reductase SDR

0.849

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Network Stats

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Functional enrichments in your networkNote: some enrichments may be expected here (why?)

Enrichment analysis is still ongoing, please wait ...

Statistical background

For the above enrichment analysis, the following statistical background is assumed: