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Abstract

To relate structural (anatomical) and functional (behavioral) measures of glaucomatous damage, a method is described for comparing visual field defects to local retinal ganglion cell (RGC) and retinal nerve fiber layer (RNFL) thicknesses. Thickness maps of the RNFL and the RGC + inner plexiform layer, obtained with frequency domain optical coherence tomography (fdOCT), were transformed into probability maps by comparing them to a normative group. As demonstrated in patients with glaucomatous damage to the macula, the probability map associated with the patient’s visual field can be directly compared to the fdOCT probability maps by taking into consideration the displacement of the RGCs.

Figures (7)

Sample thickness maps and scans from a healthy control. A. RGC + IPL thickness map (left) and a scan through the horizontal meridian with the segmentation displayed in light blue (right). B. RNFL thickness map (left) and a scan through the horizontal meridian (right). C. RNFL thickness map (left) and a scan through the center of the optic disc (right).

RGC + IPL and RNFL thickness maps for the control in Fig. 1A. Combined RNFL thickness maps from scans of the macula and optic disc. B. Same scans as in A shown with iso-thickness contours and after flipping across the horizontal axis to present in field view. C. Same as in B for RGC + IPL thickness.

Sample visual fields and OCT thickness maps. A. 24-2 (left panel) and 10-2 (second column) visual fields are shown for a healthy control along with the thickness maps for the macula RGC + IPL (middle panel) and RNFL thickness (fourth panel), and the optic disc RNFL thickness (right panel). B,C,D. Same as in A for 3 patients.