Database Description

NCG 4.0 reports information on duplicability, orthology, evolutionary appearance, interactions, function, expression of a manually curated list of protein-coding cancer genes and OncomiRs.
Cancer genes are genes with a driver role in the onset of human cancer upon mutations of their sequence and/or amplifications of their genomic locus.
The list of cancer genes is derived from the union of the Cancer Gene Census (known cancer genes) and from the results of whole genome or whole exome cancer-resequencing screenings (candidate cancer genes, see complete list of screenings).
In addition, the database also annotates possible false positives, defined as candidate cancer genes whose association with cancer is likely to be spurious.