Three capillary columns, set up in a routine screening system, were tested in temperature-programmed runs. A narrow-bore fused silica capillary, Carbowax deactivated and with a methylsilicone liquid phase, was found to be unstable at higher temperatures, giving irreproducible results and retention indices that varied considerably from those obtained on packed columns. The two other columns, a wide-bore glass capillary and a narrow-bore fused silica capillary, were polysiloxane-deactivated and had a dimethylpolysiloxane liquid phase. Although both showed good stability, reproducibility, and load capacity, retention indices for various drugs still showed discrepancies as compared to corresponding values on packed columns.

Author Information:

Franke, JP Research associate, research associate, senior research associate, and professor of toxicology, State University, Groningen,

Wijsbeek, J Research associate, research associate, senior research associate, and professor of toxicology, State University, Groningen,

Schepers, P Research associate, research associate, senior research associate, and professor of toxicology, State University, Groningen,

de Zeeuw, RA Research associate, research associate, senior research associate, and professor of toxicology, State University, Groningen,

Stock #: JFS11450J

ISSN: 0022-1198

DOI: 10.1520/JFS11450J

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Author Title Applicability of Capillary Gas Chromatography to Substance Identification in Toxicology by Means of Retention IndicesSymposium , 0000-00-00Committee E30