P A GrayDepartment of Cardiac, Vascular and Inflammation Research, St Bartholomew s and the Royal London School of Medicine and Dentistry, Charterhouse Square, London EC1M 6BQ, UKBr J Pharmacol 137:1031-8. 2002

Effects of the selective inhibition of platelet thromboxane synthesis on the platelet-subendothelium interaction

J P De La CruzDepartment of Pharmacology and Therapeutics, School of Medicine, University of Malaga, 29071 Malaga, SpainBr J Pharmacol 137:1082-8. 2002

..4. In conclusion, the effect of specific blockage of TxS together with blockage of membrane receptors for TxA(2) can surpass the effect of ASA in inhibiting the platelet-subendothelium interaction in flow conditions...

P A GrayDepartment of Cardiac, Vascular and Inflammation Research, St Bartholomew s and the Royal London School of Medicine and Dentistry, Charterhouse Square, London EC1M 6BQ, UKBr J Pharmacol 137:1031-8. 2002

..This suggests that NO-aspirin may be better tolerated than aspirin by aspirin-sensitive asthmatics...

..We also examined the combination of MMF with a selective cyclooxygenase-2 (COX-2) inhibitor, DFU, based on previous findings of excessive renal production of COX-2-derived thromboxane A2 (TXA2) in lupus nephritis...

..Thus, it may be concluded that PAF-induced platelet aggregation participates in activation of the 12-LOX pathway and is accompanied by the release of vasodepressor nerve-stimulating substances from platelets...

..aspirin resistance on several different platelet function assays, including the level of urinary 11-dehydro thromboxane B2 (Tx-M), platelet aggregation to arachidonic acid and adenosine diphosphate, and closure time on the platelet ..

Seasonal variation in parameters related to coronary heart disease risk in young men

..An understanding of these variations is important not oly for clinical evaluation and metabolic study design issues, but more importantly, to clarify their clinical significance with the seasonal incidence of CHD events...

Platelet activation in obese women: role of inflammation and oxidant stress

..Obesity, in particular abdominal adiposity, is associated with increased cardiovascular morbidity and mortality through mechanisms possibly linking the metabolic disorder to platelet and vascular abnormalities...

To measure 11-dehydro-thromboxane B2 (11-dTXB2) in urine of healthy control dogs, dogs undergoing ovariohysterectomy, and dogs with gastric dilatation-volvulus (GDV) and assess the relationship between urinary 11-dTXB2 concentrations in ..

George G ChenDepartment of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, New Territories, Shatin, Hong KongCancer Lett 234:193-8. 2006

..In conclusion, our study demonstrates that the production of TXB(2) is increased in lung tumor tissues and that such an increase can result in lipid peroxidation which may be met by an elevation in Bcl-2 expression...

In vitro effects of picotamide on human platelet aggregation, the release reaction and thromboxane B2 production

..The purpose of this study was to investigate the relationships among production of PAF, thromboxane B2 (T alpha B2), and cardiopulmonary sequelae in patients undergoing coronary artery bypass graft surgery (CABGS)...

Propofol has both enhancing and suppressing effects on human platelet aggregation in vitro

..In contrast, there is conflicting information regarding the effect of propofol on platelet function. The present study was designed to clarify the effects of propofol on platelet function and the mechanisms underlying these effects...

..To observe the effect of phenolic alkaloids of Menispermum dauricum (PAMD) on thrombosis and platelet aggregation, and to explore its mechanism of action...

Aspirin resistance in coronary artery disease is correlated to elevated markers for oxidative stress but not to the expression of cyclooxygenase (COX) 1/2, a novel COX-1 polymorphism or the PlA(1/2) polymorphism

..Assessment of their generation in these models may afford the basis for future studies on the functional role of these eicosanoids in the evolution and progression of atherosclerosis. (Blood. 2000;96:3823-3826)..

..Platelet aggregation (to sodium arachidonate, collagen, and adenosine diphosphate), bleeding time, and serum thromboxane B2 (TxB2) concentrations were measured up to 8 hours postdose on Days 1 and 8...

Influence of vitamin E on the antiplatelet effect of acetylsalicylic acid in human blood

J A Gonzalez-CorreaDepartment of Pharmacology and Therapeutics, School of Medecine, University of Malaga, Campus de Teatinos s n, Malaga, SpainPlatelets 16:171-9. 2005

..plasma (PRP) with ADP, collagen or arachidonic acid as platelet inducers, and we measured the production of thromboxane B2, prostacyclin and nitric oxide...

In vitro effects of clopidogrel on the platelet-subendothelium interaction, platelet thromboxane and endothelial prostacyclin production, and nitric oxide synthesis

María Monsalud ArrebolaDepartment of Pharmacology and Therapeutics, School of Medicine, University of Malaga, Malaga, SpainJ Cardiovasc Pharmacol 43:74-82. 2004

..All three drugs impaired the platelet-subendothelium interaction under flow conditions. With thienopyridines, the presence of endothelium did not modify the percentage of the surface coated by platelets...

Characterization of inhibition of platelet function by paracetamol and its interaction with diclofenac in vitro

..Clinically paracetamol is often used together with traditional NSAIDs, which are strong inhibitors of COX. We studied binding of paracetamol to COX and its action on platelet function together with diclofenac...

Prostacyclin, thromboxane A and the effect of low-dose ASA in pregnancies at high risk for hypertensive disorders

..The current controversy on the potential cardioprotective effect of naproxen prompted us to evaluate the extent and duration of platelet, monocyte, and vascular cyclooxygenase (COX) inhibition by naproxen compared with low-dose aspirin...

..We conclude that in this animal model of acute pulmonary embolism, infusion of BM-573 reduced pulmonary vasoconstriction. As a result, right ventricular-vascular coupling values were maintained at a maximal efficiency level...

Meloxicam does not affect the antiplatelet effect of aspirin in healthy male and female volunteers

..Urinary thromboxane and prostacyclin were unaffected by lumiracoxib. In conclusion, concomitant lumiracoxib did not interfere with the cyclooxygenase-1-mediated antiplatelet effects of low-dose aspirin...

Effects of DK-002, a synthesized (6aS,cis)-9,10-Dimethoxy-7,11b-dihydro-indeno[2,1-c]chromene-3,6a-diol, on platelet activity

Marc K HalushkaDepartment of Genetics and Center for Human Genetics, Case Western Reserve University School of Medicine and University Hospitals of Cleveland, Cleveland, USAClin Pharmacol Ther 73:122-30. 2003

..The mechanisms for the variability in antiplatelet effects of aspirin are unclear. Immature (reticulated) platelets may modulate the antiplatelet effects of aspirin through uninhibited cyclooxygenase (COX)-1 and COX-2...

..In conclusion, neither of the two naproxen doses mimed the persistent and complete inhibition of platelet COX-1 activity obtained by aspirin, but marked heterogeneity was mitigated by the higher dose of the drug...

Heritability of platelet responsiveness to aspirin in activation pathways directly and indirectly related to cyclooxygenase-1

..Diabetic patients may have a higher prevalence of platelet aspirin resistance than nondiabetic patients. Our goal was to analyze platelet aspirin responsiveness to various aspirin doses in diabetic and nondiabetic patients...

Differences in the influence of the interaction between acetylsalicylic acid and salicylic acid on platelet function in whole blood and isolated platelets: influence of neutrophils

J A Gonzalez-CorreaDepartment of Pharmacology and Therapeutics, School of Medicine, University of Malaga, Campus de Teatinos s n, 29071 Malaga, SpainPharmacol Res 56:168-74. 2007

..The variables recorded were maximum platelet aggregation intensity, thromboxane B2 (TxB2) production, and nitric oxide (NO) production (N=10 different samples in each type of experiment)...

Antiplatelet effect of sanguinarine is correlated to calcium mobilization, thromboxane and cAMP production

Jiiang Huei JengLaboratory of Dental Pharmacology and Toxicology, Department of Dentistry, National Taiwan University Hospital and National Taiwan University, College of Medicine, Taipei, TaiwanAtherosclerosis 191:250-8. 2007

..Sanguinarine may have therapeutic potential for treatment of cardiovascular diseases related to platelet aggregation...

..system, we have determined the profile of COX (6-keto prostaglandin F1 alpha (6-keto PGF1 alpha), PGE2, thromboxane B2 (TXB2) and NOS (nitrite and nitrate) metabolites released over a period of 10 days from segments of rat aorta...

Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor

The blood volumes and concentrations of thromboxane B2 (TxB2), platelet factor 4 (PF4), and fibrinopeptide A (FPA) were measured every 30 seconds in bleeding-time blood in normal subjects and in patients with idiopathic thrombocytopenic ..

Augmented contraction of the human isolated coronary artery by sumatriptan: a possible role for endogenous thromboxane

A Maassen VanDenBrinkDepartment of Pharmacology, Faculty of Medicine and Health Sciences, Erasmus University Rotterdam, The NetherlandsBr J Pharmacol 119:855-62. 1996

..These traits, including platelet number and volume, serum platelet activating factor (PAF), plasma thromboxane B2, serum insulin- like growth factor-1 (IGF-1), and total and high density lipoprotein cholesterol, will be ..

..activated microglia cells and their mediators play in DOM-induced excitotoxic neuronal injury and thus contribute to potential novel approaches for the therapy of the neuropathology associated with Amnesic Shellfish Poisoning in humans ..

..These studies will enhance our understanding of the role of integrin biology (especially in platelets), and help to achieve our long-term goal of implementing a more rational anti-thrombotic therapy. ..

..In either event, future studies would address the use of selective COX-2 or TXA2 synthase inhibitors/receptor blockers, antioxidants, and/or PGI2/PGE2 agonists in conduction with iNOS inhibitors as therapies for LN. ..