Crypts are 2 - 3x larger and more dilated than normal crypts, may have a foci of dysplasia

ACF can be subclassified as dysplastic, nondysplastic or mixed type

Dysplastic ACF resemble adenomas

Molecular / cytogenetics description

Dysplastic ACF are present both in familial adenomatous polyposis (FAP), which is the result of a germline mutation of the APC gene; and in sporadic colorectal carcinomas, due to mutations of KRAS (Am J Pathol 2005;166:1069)

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