author of the study. This is a landmark study as millions of people ...The trial which included 154 adult participants with chronic HCV was... These data show that even higher-than-normal doses of silymarin don't......

author of the study. "This is a landmark study as millions of people around the world are looking for supplements and other forms of alternative medicines to help reduce ALT levels every year."

The trial, which included 154 adult participants with chronic HCV, was conducted over the course of two years at four medical centers in the United States. Participants were randomly assigned to receive 420mg silymarin, 700mg silymarin or a matching placebo administered three times/week for 24 weeks, a standard duration of treatment. After 24 weeks, researchers found only two participants in each treatment group achieved lowered ALT levels. Neither the average decline in ALT activity nor quality-of-life measures at the end of treatment differed significantly across the treatment groups.

"These data show that even higher-than-normal doses of silymarin don't significantly reduce ALT levels for patients with HCV," said Reddy, noting that the doses used in the trial were three and five times higher than the customary dose. "At the end of the trial we saw no significant changes in physical or mental health assessments between the patients who received treatment, and those who did not. Quality-of-life measures were also largely unchanged."

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