Tag: "painstaking" at biology news

... of Science. "Hunting for human genes is amassive, painstaking undertakingthat typically takes years and coststens or even hundreds of millions ofdollars," said co-author Pavel A.Pevzner, a professor of mathematicsand computer science. With thismethod, we can find a human geneif an analogous gene from anotherspe...

...was found first. It was discovered by brute force, painstaking scrutiny of every gene within the targeted region, an effort led by Kazuya Yamagata, M.D., at the University of Chicago, and Roger D. Cox, Ph.D., at the Wellcome Trust Centre for Human Genetics. The researchers found that patients from MODY3 families...

...about pilusassembly. During nine years of painstaking research, the group discovered that aprotein called a chaperone plays a critical role in molding pilus subunits andadhesins into their correct 3-D shapes and transporting them to the membranethat surrounds the bacterial cell. Another protein, called ...

...thes for double-duty as asphere grinders. Thefinal painstaking round of hand-smoothing, known as "lapping,"done by specialized artisans, can take hours or even days."There's now no efficient way, and certainly no single machine,for making high-precision ground aspheres from start to finish,"Golini says. Man...

...tor genes has, until recently, taken many years of painstaking work. But the method used by Tailor employs a retrovirus as a kind of Trojan horse. A retrovirus containing the susceptibility gene is used to infiltrate the resistant cell and deliver its genetic cargo. The process can be complete in as little as si...

...king draft will then serve as the scaffold for the painstaking but criticalwork of finishing, which involves closing gaps and correcting errors, leading tocompletion of the final high-quality, continuous human DNA sequence by 2003 atthe latest. "This joint initiative marks a major expansion of the collaborative ...

...rancisco crystallized the protein -- a criticalbut painstaking process of trial and error that is essential to be able to viewprotein structure under ultra high magnification. Once Complex II was crystallized, team members from the California Institute ofTechnology imaged its three-dimensional structure with a t...

...ed in a massive, collaborative analysis, requiring painstaking study ofdata on thousands of plant species from all over the world. The team was led byscientists from the United States, working with scientists from Japan, Canada,Mexico, the United Kingdom, Germany, France, New Zealand, Switzerland, Sweden,Finland...

...rings a brain cell to suicide? Through a series of painstaking experimentsfunded by the National Institutes of Health, Halterman showed that two genesthat help make cancerous tumor cells tough to kill are also involved in causingbrain damage after a stroke. The genes, HIF1a and p53, play a vital role in ...

...ge amounts of venom." The scientists then began a painstaking process of separating, or fractionating, the raw venom into its 100-150 different components and testing them to identify the most active component. This turned out to be a 35-amino-acid peptide the researchers labeled GsMTx-4 (for Grammostola spatu...

... Through the careful use of this technique and the painstaking analysis of the resulting data, Higuchi was able to detect the direction of the motor's movement in two directions down the length of the microtubule and also around the circumference of the tubule. The analysis showed that the normal Ncd motor mov...

...way to spot a useful drug, for example, has been a painstaking method isolating cell membranes and making measurements of minuscule changes in current. "But now that we know that dimers --the double CFTR molecules --are the working version in cells, we can screen for them, and they're far easier to detect," Li ...

...ing these "comparative gene maps" has been a slow, painstaking process, something biologists do by hand over weeks, months or years, using data painstakingly collected in "wet labs" and analyzed with software designed to interpret only one map at a time. Now, Cornell University researchers have come up with a w...

...er clip scurried in the shadow of the dinosaurs. A painstaking examination of its 12 millimeter-long fossil skull in the 25 May issue of the journal Science suggests that this miniature mammal relative is the closest known relative to the living mammals, and possessed crucial mammalian features forty million y...

...ng the genes that cause specific diseases often a painstaking process requiring months of laboratory trial and error.Now researchers have designed a computer program with the potential for dramatically speeding up the search for disease-causing genes and hastening the discovery of new drugs to treat a wide rang...

...and areas marked by volcanic lava. Their dirty and painstaking work is revealing an ecosystem invaded by foreign plant species, a problem Ballard said has been underestimated in the past. "You have to hike far into the forest to find areas where there aren't many invasive plants," he says. "The vast majority of...

... who led a team of researchers through a series of painstaking and unorthodox approaches to identify the molecule one atom at a time. The search began in 1993 when Princeton biologist Bonnie Bassler found genes that allow some ocean-dwelling bacteria to emit a blue glow. The bacteria glow only when there are eno...

... key step in cloning. At present it takes hours of painstaking work with a microscope to remove the nucleus of an egg cell and replace it by fusing the denucleated egg with another cell. "If somebody's got something like that, obviously it would make everybody's life easier," says Tanja Dominko of Advanced Cell...

...the role of APC in development through a series of painstaking experiments that Rappleye conducted with mutants of the roundworm C. elegans. Over a two-year period, Rappleye found mutants with impaired APC function and demonstrated that the protein complex helps the sperm push a protein known as PAR-3 away from...

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