Translational science seeks to speed up the process of moving research discoveries from the laboratory into healthcare practices. Numerous scientific and organizational roadblocks can act as obstacles along the path of translation and ultimately hinder the speed of progress in medical research. The National Center for Advancing Translational Sciences (NCATS) was established by the National Institutes of Health (NIH) to transform and accelerate the translational research process, with the intended result of getting treatments to more patients faster. The field of Translational Science aims to bridge these gaps by:
Developing new approaches, technologies, resources and models
Demonstrating the usefulness of new approaches, technologies, resources and models
Disseminating the resulting data, analyses, and methodologies to the broad scientific community
Introduction to Translational Science is an introductory course that provides students with a broad understanding of translational science, the types of research that are conducted under the translational science umbrella, and how this research impacts the public at large.The course will compare and contrast current impediments to clinical research with the potential of translational science and will include selected case studies from the University of Rochester.

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T4 - Translation to Communities and Participating in Clinical and Translational Research

The fifth lesson of Introduction to Translational Science provides an introduction to T4 research, which is research that translates findings from practices (T3 research) to communities, both domestic and globally. T4 research is often conducted through prevention and outcome studies, mass screening studies, and health policy studies.The sixth lesson of Introduction to Translational Science provides an overview of how interested individuals can participate in clinical and translational research; as an independent research, as a clinical research professional, and as a study volunteer. The final segment of the module demonstrates what a typical study volunteer will encounter if they are selected to participate in a clinical trial.

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Martin S. Zand, MD, PhD

Professor of Medicine – Nephrology

Текст видео

[MUSIC] The activities of a clinical and translational science researcher is similar to what you would think of any researcher as doing. They're going to think about what research question they want to answer. The design, how they're going to collect their data, interpret it. And then how they're going to measure what I always call the so what question. Did it make a difference? Except clinical and translational science researchers get to think around a larger range of questions. Anywhere from the individual to the population. They're going to take their results they're going to disseminate it, they're going to do scholarly publications and presentations. They're going to collaborate within networks of researchers and share their data to make sure that it's all building upon each other. And then they're going to mentor the next generation of researchers that is going to continue this work. A Physician Scientist is a very pivotal person in translational science research. It's someone who has two lenses. One of a clinician and a researcher. And can translate the research that they're doing to pursue and build on this body of knowledge that we're trying to pursue. Much like the researchers you've seen in the previous modules in this MOOC. They are someone who has an M.D. degree. And then also might have a PhD or a Masters degree to that, and they think about the translation of what the research is doing and what it will mean for clinical care. Often they're anchored in medical centers or in academic medical institutions. And usually in addition to teaching and in practicing in clinical care, they also teach and are in charge of mentoring and direct teaching students and trainees and researchers. So, there are couple of different path ways that someone can become a physician scientist. I think probably the most traditional method might be someone who started out in medical school but that reasearch and asking questions was a really important component for them. So that they pursued other education while they were in medical school. Maybe they did time out and they pursued a Master's Degree or a PhD and integrated that with their MD or some of them finished their MD and pursue an advanced degree after the fact. And now because the field is becoming so diverse and rounded. We even have physicians who might have taken a year off training or additional time just to have a focused, dedicated research experience that isn't degree granting but gives them specialization maybe in bioinformatics for instance. You know looking probably across the nation at all the CTSA hubs, we're all supporting the development and growth of research scientists in different ways. Here at the University of Rochester, we have four different programs that really help support those who would have both the lens of a physician and a researcher. Our first program is the art program, it's the academic research track. That is for a medical student who wants to take a year out and have a really focused research experience. So they can develop the skills of asking questions, design implementation and analysis around a single product. Then we have what we call is our MSTP program. And that is for our students who, they apply to our medical school program with this track in mind and get accepted to both. And its integrated PhD MD program where they have this very unique curriculum built into the experiences of both that play off of each other and have it in their place. So they'll do two years of the basic science. In the medical school curriculum they'll move into their PhD, but there was a connectivity piece to it. And then they transitioned back to the last two years of medical school for their clinical experiences to finish out. And at the end, they both get their MD and their PhD degree. And then we have a stand-alone PhD program in translational biomedic science. And this is something that would be independent. So this is for a student who might have started the MD program and then thought after the fact that they wanted to get their PhD, they can apply directly into this program. And it is a really kind of near to my heart, I think that the faculty who are running this are doing an excellent job, but the Theme of this Doctoral Program is Molecules to Populations. And can really be an in-depth experience for someone who wants to get a PhD in Translational Biomedical Science. And then lastly, there's the part of the work force who might have finished their MD, maybe you're in the residency or finished their residency program and are in the workforce but are junior faculty. And they're interested in translational science and have recognized the need to have additional training. So they can enter into our KL2 program, which is a two year program where they get mentored support to pursue research, they get protected time. And strong mentorship and support to develop the same skills, or similar skills, that individual who maybe did the PhD or even just the year out program did. And as a result, we are really growing. A really strong workforce that can translate both the strengths of both research and clinical and are building this wonderful community of translational science researchers. [MUSIC]