You've seem to have bumped into a minor glitch of Integration Studio. We've detected in both Integration Studio 5.0 and 5.1 latest revisions patches, and it's just a annoyance popup message every time you open the extension in Integration Studio, but no changes will be performed on the extension.

So the impact is negligible.

The OutSystems R&D is already on top of this problem, and I believe it will be fixed in the upcoming revision patches of both Integration Studio 5.0 and Integration Studio 5.1.