..Different models exist for the analysis and their accuracy and applicability depend on the case at hand. Here we discuss current models and suggest a new model of broad applicability, including examples of its implementation...

..Streptococcus pneumoniae is one of the most important causes of microbial diseases in humans. The genomes of 44 diverse strains of S. pneumoniae were analyzed and compared with strains of non-pathogenic streptococci of the Mitis group...

Pyrosequencing-based comparative genome analysis of the nosocomial pathogen Enterococcus faecium and identification of a large transferable pathogenicity island

..Genome annotations can contain inconsistencies and errors that hinder comparative analysis even within a single species. Tools are needed to compare and improve annotation quality across sets of closely related genomes...

..bolletii and the assessment of inducible clarithromycin resistance. This method can be easily integrated into a routine workflow to provide subspecies-level identification within 24 h after isolation of the M. abscessus group. ..

..With the availability of the complete genomes of both species and excellent genetic tools for the host, the wMel-D. melanogaster symbiosis is now an ideal system for studying the biology and evolution of Wolbachia infections...

Bacterial genome sequencing

Herve TettelinInstitute for Genome Sciences, Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, USAMethods Mol Biol 551:231-47. 2009

..We review a number of sequencing technologies and provide examples of applications. We also discuss the impact genomics and new DNA sequencing approaches have had on various fields of biological research...

Whole-genome association study on tissue tropism phenotypes in group A Streptococcus