In this paper, we consider a model describing the dynamics of Hematopoietic Stem Cells (HSC) disease with chemotherapy. The model is given by a system of three ordinary differential equations with discrete delay. Its dynamics are studied in term of local stability of the possible steady states for the case without drug intervention term. We prove the existence of periodic oscillations for each case when the delay passes trough a critical values. In the end, we illustrate our results by some numerical simulations.

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