In 1905, Manzhouli was designated a trading center in the Sino-Japanese Treaty of 1905, greatly boosting Manzhouli's growth. In 1908 the Manzhouli customs was set up. Under the Republic of China, Manzhouli came under the jurisdiction of the province of Hsingan. In 1927, Manzhouli was designated as a city. Although with Hsingan and surrounding areas, Manzhouli came under Japanese control in 1931, and was part of the Empire of Manchukuo from 1932 to 1945. It became part of Inner Mongolia under the China from 1946.

In 1992, Manzhouli became one of the first land border cities opened up by the People's Republic of China. It has since experienced somewhat of a boom as a center of border trade between China and Russia.[1]

Manzhouli is located on the Hulunbuir grasslands. Lake Hulun to its immediate south is the PRC's fifth largest freshwater lake with an area of 2,600 square kilometres (1,000 sq mi) and an average depth of just 5 metres (16 ft).

Manzhouli has a rather dry, monsoon-influenced humid continental climate (KöppenDwb), with temperatures in winter capable of plummeting below −40 °C (−40 °F). However, in each month there is more than 55% of possible sunshine, and over three-fourths of annual precipitation occurs from June to August.

Manzhouli is divided into ten subdistricts and one town. Six of the subdistricts of Manzhouli are grouped into a district. Technically however, only a prefecture-level city (half a level higher than Manzhouli) can have districts, so Manzhouli's lone district is not officially listed.