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World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar. Best Paper Award : Dr. Muhammad Baqir MR Fakhrildin
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Abstract

The objective of the present study was to formulate carvediloleudragit
® RS100 nanoparticles and investigate the physic-chemical
characteristics of the prepared nanoparticles. The nanoparticles of
carvedilol with eudragit® RS100 were formulated using the emulsion
solvent evaporation. Several process parameters, i.e., drug/polymer
ratio, aqueous phase volume and speed of sonication were considered
to achieve optimal preparation condition. The physicochemical
characteristics of nanoparticles were studies applying particle size
analysis, differential scanning calorimetry, Fourier transform infrared
spectroscopy, scanning electron microscopy and atomic force
microscopy. The release rate of carvedilol from various drug/polymer
nanoparticles was investigated as well. All the prepared formulation using eudragit® RS100
resulted in nano-range size particles (280-467 nm) as detected by Zeta Sizer. The entrapment
efficiencies were observed for all the nanoparticles in a range of 67% to 91%. The
nanoparticles of carvedilol- eudragit® RS100 displayed no chemical interaction between
drug and polymer molecules. The SEM image revealed that particles were smooth, spherical
in shape. The particle aggregation of the particles was observed by AFM study. The
nanoparticles exhibited the slower release of drug in comparison with the intact drug and
polymer molecules. According to the finding, formulation of carvedilol- eudragit® RS100
nanoparticles was able to improve physicochemical characteristics of the drug and possibly
will enhance the antihypertensive effects of the drug following its oral administration.