Eukaryotic Translation Initiation Factor 4E (EIF4E) ELISA Kits

The protein encoded by EIF4E is a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5' end of cellular mRNAs. Additionally we are shipping EIF4E Antibodies (259) and EIF4E Proteins (18) and many more products for this protein.

Our work demonstrates that a single phosphorylation site on the 5' cap-binding protein eIF4E is a critical mechanism for changes in nociceptor excitability that drive the development of chronic pain.

data suggest a physiological role for MNK1a-Ser (show SIGLEC1 ELISA Kits)(353) phosphorylation in regulation of the MNK1a kinase, which correlates with increased eIF4E phosphorylation in vitro and in vivo.

Results of our study suggest that the eIF4E/Fmr1 (show FMR1 ELISA Kits) double mutant mouse may be a reliable model to study cognitive dysfunction in the context of autism spectrum disorder.

Our findings identify the eIF4E- beta-catenin (show CTNNB1 ELISA Kits) axis as a critical regulator of lung cancer cell growth and survival, and suggest that its pharmacological inhibition may be therapeutically useful in lung cancer.

mice in which eukaryotic translation initiation factor 4E (eIF4E) cannot be phosphorylated are resistant to lung metastases in a mammary tumor model, and cells isolated from these mice exhibit impaired invasion.

it is proposed that a balanced regulation of the truncation of the cap-binding complex component eIF4F (show EIF4A2 ELISA Kits) and degradation of 4E-BP1 (show EIF4EBP1 ELISA Kits) and/or truncation of 4E-BP2 (show EIF4EBP2 ELISA Kits) that together ensures correct translational control during the dynamic process of conceptus implantation

Results show that in pigs, the truncated eIF4E is located in the endometrial luminal epithelium during implantation. Neither glandulary tissue nor stroma expressed any truncated eIF4E.

The translation initiation in the endometrium is differently regulated by the two eIF4E forms with regard to different 4E-BP1 (show EIF4EBP1 ELISA Kits) abundance and phosphorylation as well as different eIF4E/4E-BP1 (show EIF4EBP1 ELISA Kits) binding dynamic depending on the type of implantation.

Modified translational initiation of eIF4E may particularly regulate protein synthesis during conceptus attachment at the time of implantation in swine.

Translation initiation factor eIF4E is phosphorylated during in vitro maturation of pig oocytes with a maximum in metaphase II stage oocytes.

EIF4E Antigen Profile

Antigen Summary

The protein encoded by this gene is a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5' end of cellular mRNAs. The encoded protein aids in translation initiation by recruiting ribosomes to the mRNA. Association of this protein with the 4F complex is the rate-limiting step in translation initiation. Three transcript variants encoding different isoforms have been found for this gene.