More Details about

Antibody Type

Polyclonal

Host

Rabbit

Isotype

IgG

Reactivity

Human,Mouse,Rat,Chicken,Pig,Guinea Pig,

Concentration

1ug/uL

Application

IF

Background

IL-10 protein is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract.