Here’s a similar situation to the Cities In Motion issue, this particular CAD software also has a problem running on ATI/AMD drivers newer than Catalyst 10.4, or at least 10.4 looks reliable enough to function properly. After launching, amdkmdap has a driver reset when the 3d rendering panel appears, crashing the application.

The fix is nice and simple, just place the appropriate OpenGL driver into the program’s folder where CityEngine.exe is.

If you have any other OpenGL game or application that is crashing after 10.4, try this fix or the Cities in Motion one.