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CD59 ELISA Kits (CD59)

On www.antibodies-online.com are 45 CD59 ELISA Kits from 13 different suppliers available. Additionally we are shipping CD59 Antibodies (583) and CD59 Proteins (32) and many more products for this protein. A total of 671 CD59 products are currently listed.

More ELISA Kits for CD59 Interaction Partners

Human CD59 interaction partners

we demonstrated that CD59 regulation by SOX2 (show SOX2 ELISA Kits) is required for stem cell evasion of complement surveillance. This finding highlights the importance of complement surveillance in eliminating CSCs and may suggest CD59 as a potential target for cancer therapy.

The results indicate that shear stress is an important mediator in endothelial progenitor cells expression of CD59 regulated by the extacellular matrix-integrin alphaVbeta3-F-actin pathway, which is a key factor in preventing membrane attack complex-mediated cell autolysis.

Data show that following 4 patients with CD59 Cys89Tyr mutations who are treated with eculizumab, no strokes occurred and non-permanent neurological insults underwent resolution without any new neurological exacerbations.

There is an altered pattern of CD55 (show CD55 ELISA Kits) and CD59 expression on RBCs of SCD (show SCD ELISA Kits) Patients; however, it does not seem to play a causal role in the pathophysiology of anemia, and is unlikely to be influenced by the level of erythropoietin (show EPO ELISA Kits) or other inflammatory mediators.

Pig (Porcine) CD59 interaction partners

Data demonstrate that the resistance of neonatal porcine Sertoli cells to human xenoantibody and complement-mediated lysis is associated with low expression of xenoantigen alpha-Gal and high production of the complement inhibitors clusterin (show CLU ELISA Kits) and CD59.

Mouse (Murine) CD59 interaction partners

This study support a role of Cd59a in controlling the innate immune status of the RPE-choroidal complex and emphasizes the particular vulnerability of this ocular compartment to the dysregulation of alternative complement pathway during aging

results implicate CD59 as an important modulator of the immune response in NMO, and provide a novel animal model of NMO that closely recapitulates human NMO pathology.

Soluble forms of CD59 (sCD59) have been investigated in mouse laser-induced choroidal neovascularization, a model for "wet" age related macular degeneration.

both CD59 and C-PC could inhibit the progress of atherosclerosis, and the anti-atherosclerotic effects of C-PC might be fulfilled by promoting CD59 expression, preventing smooth muscle cell proliferation and the apoptosis of endothelial cells

While the connection between CFH (show CFH ELISA Kits) deficiency and failure to upregulate CD59a remains unknown, these results suggest that expression of CD59 is tissue-specific and that neuroretinal regulation depends on CFH (show CFH ELISA Kits).

CD59 has a role in growth of the choroidal neovascular complex in mice

CD59 Antigen Profile

Antigen Summary

This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. This protein also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene.