3

Tremors:
Initially, one may notice only a unilateral tremor when the hand is resting. Later there can be imbalance and stiffness using arms and legs, but pts can also experience cognitive changes, and problems with swallowing. The issues are progressive, but can be treated and often very well controlled.
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4

Loss of dopamine:
Gradual loss of Dopamine cells in the brain and specifically an area called substantial nigra leads to a group of clinical symptoms and signs: tremor at rest, slow movements, rigid muscles, gait shuffling, lack of facial expression, small handwriting etc.
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