Evolution of Cellular and Viral Resistance in HIV-infected Patients With Lymphoma

Trial Information

Evolution of Cellular and Viral Resistance in HIV-infected Patients With Lymphoma

The study team will take two or three tubes of blood on three occasions during the course of
chemotherapy. The total amount of blood required for this research project is 64mL
(approximately 4 tablespoons).

This will allow better understanding of the changes that take place in the blood and the HIV
virus itself. It is hoped that this will provide new insights that may aid the understanding
and treatment of HIV patients with lymphoma.

Inclusion Criteria:

- The ability to understand and sign a written informed consent form, prior to
participation in any screening procedure and must be willing to comply with all study
requirements.

- Documented HIV-1 infection.

- Diagnosis of lymphoma (with the exclusion of the five subjects that will be
controls).

- On cART or about to start cART as part of clinical routine care before the initiation
of chemotherapy.

Exclusion Criteria:

- Receiving anti-tuberculosis treatment.

Type of Study:

Observational

Study Design:

Observational Model: Case Control

Outcome Measure:

Development of multi-drug resistance (in terms of expression of transmembrane transporters and their transcriptional regulators) in HIV-infected patients with lymphoma.

Outcome Time Frame:

3 years

Safety Issue:

No

Principal Investigator

Marta Boffito, Dr

Investigator Role:

Principal Investigator

Investigator Affiliation:

St Stephen's AIDS Trust

Authority:

United Kingdom: Medicines and Healthcare Products Regulatory Agency

Study ID:

SSAT 042

NCT ID:

NCT01330342

Start Date:

May 2011

Completion Date:

May 2014

Related Keywords:

HIV

Lymphoma

Lymphoma

Name

Location

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