Mutation details: This transgene consists of the cytomegalovirus immediate early enhancer-chicken beta-actin hybrid (CAG) promoter, a floxed lacZ gene, human FUS cDNA with the R521C mutation, IRES, and EGFP coding sequences. Cre-excision of the loxP flanked lacZ DNA allows for translation of FUS and EGFP. Two lines were generated: 673, and 682. Line 682 was chosen as a representative line.
(J:216672)

Generation of the Tg(CAG-lacZ,-FUS,-EGFP)629Gyu and Tg(CAG-lacZ,-FUS*R521G,-EGFP)682Gyu transgenes

Phenotypes

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Disease models

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Mouse strains and cell lines
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