Under the heading EDITOR DECISION, upload your revised paper as AUTHOR VERSION using Browse and Upload buttons. More than one file can be uploaded: the Upload button must be pressed for EACH file.

Use the NOTIFY EDITOR email to inform editors that the revised version has been submitted.

Manuscript will be carefully scrutinized for evidence of plagiarism, duplication and data manipulation; in particular, images will be carefully examined for any indication of intentional improper modification.

The Corresponding Author must submit the manuscript online-only through our Manuscript Submission System.

Authors are required to suggest at least two potential reviewers for their manuscript.

Manuscript formatPlease note the following requirements for the Brief Notes:

Main text: up to 10,000 characters, spaces included (not including abstract, illustrations, and references)

Abstract length: up to 900 characters, spaces included

Table/Figure limits: up to 3 tables and figures

References: up to 40 references

General: each manuscript should be typewritten, double-spaced throughout; pages should be in A4 format and numbered, lines should be left numbered in continuum (10-digit numeric system).

The manuscript should be divided into: Title page; Abstract; Text; Acknowledgments; References; Tables; Figure legends. The Title page should contain the following information: title of the paper; initials of the name and full surname of author(s); full name and address of the institution(s) where the work was done; complete address (phone and fax numbers, E-mail address) of the corresponding author; key words (no more than seven); authors' contributions, i.e., information about the contributions of each person named as having participated in the study (http://www.icmje.org/#author); disclosures about potential conflict of interest. The Abstract must be analytically informative. The Text should normally be subdivided into: Introduction, Materials and Methods, Results, Discussion.

In the Introduction, which should be concise, the purpose of the research must be clearly explained. Materials and Methods should report all information useful for repetition of the experiments. Generic and specific names should be typed in italics. When chemicals are quoted, well defined, registered names should be used following the subject index of chemical abstracts. When the text refers to enzymes, the trivial names should be given as published in Enzyme nomenclature by Academic Press, 1984. Units of measurements should be those recommended by the International Committee for the Standardization of Units of Measurements, please check this site (http://www.bipm.org/en/si/si_brochure) for Uniform Requirements. Results should include the presentation of all experimental data. The description of the original observations must be concise, avoiding the use of both tables and graphs to illustrate the same results. An adequate statistical analysis of quantitative data should be provided. General considerations and conclusions should be reported in the Discussion only.Acknowledgments will be placed at the end of the text.

References should be prepared strictly according to the Vancouver style, which is present in EndNote); for details see the URL: http://www.nlm.nih.gov/bsd/uniform_requirements.html. Where available, URLs for the references should be provided directly within the Word document. References must be numbered consecutively in the order in which they are first cited in the text, and they must be identified in the text by arabic numerals. References to personal communications and unpublished data should be incorporated in the text and not placed under the numbered References.

The legends of Tables and Figures should be informative and concise without duplicating information presented within the body of the text. Remarks such as "see comments in the text" must be avoided.

Illustrations. Symbols and abbreviations used in figures can be defined in the figure caption or note or within the figure itself. Please avoid the use of bold face or greater size for the characters. Please remember that in order to promote good management of the space available images must take up the least space possible without compromising clarity. Figures and graphs must be submitted as .tif or .jpg files, with the following digital resolution:

Color (saved as CMYK): minimum 300 dpi

Black and white/grays: minimum 600 dpi

Lettering of figures must be clearly labelled. Several figures should be grouped into a plate. Micrographs contained in the same figure should be marked with letters. There is no additional cost for publishing colour figures. Figures should be designed using a well-known software package. In case a figure has been published earlier, the original source must be acknowledged; authors must as well submit written permission from the copyright holder to reproduce the material.

To ensure that the English used is of the appropriate standard, manuscripts by non native-speaking authors will be edited by an English-speaking consultant. Published papers will bear the date of final acceptance.

Peer-review policy

All manuscripts submitted to our journal are critically assessed by external and/or in-house experts in accordance with the principles of peer review (http://www.icmje.org/#peer), which is fundamental to the scientific publication process and the dissemination of sound science. Each paper is first assigned by the Editors to an appropriate Associate Editor who has knowledge of the field discussed in the manuscript. The first step of manuscript selection takes place entirely in-house and has two major objectives: i) to establish the article’s appropriateness for our journals’ readership; ii) to define the manuscript’s priority ranking relative to other manuscripts under consideration, since the number of papers that the journal receives is much greater than it can publish. If a manuscript does not receive a sufficiently high priority score to warrant publication, the editors will proceed to a quick rejection. The remaining articles are reviewed by at least two different external referees (second step or classical peer review). Manuscripts should be prepared according to the Uniform Requirements established by the International Committee of Medical Journal Editors (ICMJE) (http://www.icmje.org/#prepare).

Authorship: all persons designated as authors should qualify for authorship according to the ICMJE criteria (http://www.icmje.org/ethical_1author.html). Each author should have participated sufficiently in the work to take public responsibility for the content. Authorship credit should only be based on substantial contributions to i) conception and design, or analysis and interpretation of data; and to ii) drafting the article or revising it critically for important intellectual content; and on iii) final approval of the version to be published. These three conditions must all be met. Participation solely in the acquisition of funding or the collection of data does not justify authorship. General supervision of the research group is not sufficient for authorship. Any part of an article critical to its main conclusions must be the responsibility of at least one author. Authors should provide a brief description of their individual contributions.

Obligation to Register Clinical Trials (http://www.icmje.org/#clin_trials): the ICMJE believes that it is important to foster a comprehensive, publicly available database of clinical trials. The ICMJE defines a clinical trial as any research project that prospectively assigns human subjects to intervention or concurrent comparison or control groups to study the cause-and-effect relationship between a medical intervention and a health outcome. Medical interventions include drugs, surgical procedures, devices, behavioral treatments, process-of-care changes, etc. Our journals require, as a condition of consideration for publication, registration in a public trials registry. The journal considers a trial for publication only if it has been registered before the enrollment of the first patient. The journal does not advocate one particular registry, but requires authors to register their trial in a registry that meets several criteria. The registry must be accessible to the public at no charge. It must be open to all prospective registrants and managed by a non-profit organization. There must be a mechanism to ensure the validity of the registration data, and the registry should be electronically searchable. An acceptable registry must include a minimum of data elements (http://www.icmje.org/#clin_trials). For example, ClinicalTrials.gov (http://www.clinicaltrials.gov), sponsored by the United States National Library of Medicine, meets these requirements.

Protection of Human Subjects and Animals in Research:when reporting experiments on human subjects, authors should indicate whether the procedures followed were in accordance with the ethical standards of the committee responsible for human experimentation (institutional and national) and with the Helsinki Declaration of 1975 (as revised in 2008). In particular, PAGEPress adopts the WAME policy on Ethics in Research (http://www.wame.org). Documented review and approval from a formally constituted review board (Institutional Review Board - IRB - or Ethics committee) is required for all studies (prospective or retrospective) involving people, medical records, and human tissues. When reporting experiments on animals, authors will be asked to indicate whether the institutional and national guide for the care and use of laboratory animals was followed.

Submission Preparation Checklist

As part of the submission process, authors are required to check off their submission's compliance with all of the following items, and submissions may be returned to authors that do not adhere to these guidelines.

The submission file is in Microsoft Word, RTF, or ODT document file format.

The submission has not been previously published, nor is it before another journal for consideration.

The text is double-spaced; uses a 12-point font; employs italics, rather than underlining (except with URL addresses); lines are left numbered in continuum; and all illustrations, figures, and tables are placed at the end of text.

Where available, URLs for the references have been provided.

The text adheres to the stylistic and bibliographic requirements outlined in the Author Guidelines, which is found in "About the Journal".

I confirm that I have suggested at least two reviewers for my manuscript (names and email addresses provided in the field "Comments for the Editors”).

I understand that this journal charge an Article Processing Fee for publication. I confirm that I will pay the amount due whether my manuscript will be accepted for publication.

Copyright Notice

PAGEPress has chosen to apply the Creative Commons Attribution License (CCAL) to all manuscripts to be published. An Open Access Publication is one that meets the following two conditions: 1. The author(s) and copyright holder(s) grant(s) to all users a free, irrevocable, worldwide, perpetual right of access to, and a license to copy, use, distribute, transmit and display the work publicly and to make and distribute derivative works, in any digital medium for any responsible purpose, subject to proper attribution of authorship, as well as the right to make small numbers of printed copies for their personal use. 2. A complete version of the work and all supplemental materials, including a copy of the permission as stated above, in a suitable standard electronic format is deposited immediately upon initial publication in at least one online repository that is supported by an academic institution, scholarly society, government agency, or other well-established organization that seeks to enable open access, unrestricted distribution, interoperability, and long-term archiving. Authors who publish with this journal agree to the following terms: 1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. 2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal. 3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.

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The European Journal of Histochemistry [eISSN 2038-8306] is an Open Access, peer-reviewed journal published by PAGEPress®, Pavia, Italy. All credits and honors to PKP for their OJS.