This is an easy one

Originally Posted by rogerk

I need the quickest route from St Louis to San Francisco. Unfortunately, this is not a pleasure trip....just need to get there quickly. Appreciate any advice.

Sorry, it will not be a pleasure trip for you. The fastest route is pretty simple: I-70 to I-25 to I-80 to San Francisco. This is about 2100 miles and if only stopped for fuel, it will take about 35 hours of driving.