"The Bioruptor Pico is a very well-manufactured piece of equipment and has so far worked flawlessly for sonicating DNA for library sequencing. It was very easy to un-package, setup, and run, and maintenance is also quite easy as long as you have a good source of lots of distilled water that is not de-ionized. Lastly, it is impressive that comparable results can be achieved with a lower number cycles than on Pico's larger sibling."

"We had this machine for two months. Thus far, we are pleased with its performance in terms of user-friendliness and result reproducibility. It is too early to say whether it will deliver the same degree of reproducibility in a year or two, which has been an issue with the previous Bioruptor model."

"The Bioruptor Pico is an easy-to-use, reliable instrument. It reproducibly shears DNA and chromatin from cultured cells and mouse tissue. Optimization of shearing conditions can be done quickly. The Bioruptor Pico has been indispensable for shearing the small volumes required for DNA and chromatin from mouse tissue and tumors."

Application Area:DNA shearing for MeDIP and chromatin shearing for ChIP.

"Diagenode's Bioruptor® ultrasonicator devices are indeed the "Most cited ultrasonicator" and the most popular in the field of Epigenetics as well as many other fields of biomedical research. The shearing of chromatin by sonication is a critical step for the success of gene target (ChIP) or large genome Next-Generation Sequencing technology (ChIP-Seq) for analysis the protein-DNA interactions in vivo. With my extensive experience with Diagenode's Bioruptor I found it the most easy to be used, importantly very reproducible from one experiment to another, with the best quality of results. I highly recommend to my colleagues the Diagenode's Bioruptors as well as their large number of other product that I have experience: epigenetic products, antibodies.
Explanation of rating: 1. Ease of Use: simple, minimum time the device to be set up for sonication. 2. After Sales Care: Diagenode has excellent customer service and technical survive support. 3. Value for Money: In my experience the devices are reliable and could be use for many years without and change in the quality of results.
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"This state-of-the-art equipment makes sonication so smoothly. It is very easy to handle and the results are highly reproducible. It is a must-have instrument for people working with chromatin shearing."

"Extremely accurate and easy to use. Expensive, but in my opinion, the best choice."

Review date: 31 May 2012 | Bioruptor® Pico

The Bioruptor® Pico is the new next-generation all-in-one shearing device, highly optimized for DNA shearing for next-generation sequencing, chromatin shearing for ChIP-seq applications, RNA shearing, protein extraction, and cell/tissue lysis. The Pico is the shearing device of choice for sequencing applications, providing optimal yields, lengths, and consistency and excels in shearing different fragment size ranges, which are frequently required for downstream applications (e.g. bridge amplification) for sequencing. Moreover, the Pico provides flexibility in other applications saving the need to buy additional equipment. Unlike competing systems, the Pico has high throughput capabilities and can process up to 12 samples at once.