Gentle Devil's Claw

This section is compiled by Frank M. Painter, D.C.Send all comments or additions to:Frankp@chiro.org

From The April 2001 Issue of Nutrition Science News

by Anthony Almada

One would not expect a plant with a diabolically painful name like devil's claw (DC) (Harpagophytum procumbens) to relieve arthritis pain. Yet several clinical studies have shown this herb to exert some pain relief for various musculoskeletal conditions. [1-4] Results of a recent German study involving 197 subjects with low back pain showed a 600 or 1,200 mg daily dose of DC extract (providing 50 or 100 mg of harpagoside, a marker constituent in DC extracts required in the German Commission E monographs) offers better pain relief than placebo. [3] However, subjects in the DC group experienced more frequent gastrointestinal upset.

In another study, 122 subjects with knee and hip osteoarthritis received 2.6 g/day of DC for four months while another group received an anti-osteoarthritic drug. Results revealed nearly equal symptom relief plus reduced pain reliever/anti-inflammatory medication use in the DC group. [1] As with many botanical extracts, the composition and chemical makeup can vary from manufacturer to manufacturer. Although we don't know the exact role harpagoside may play as an active ingredient, recent test tube studies suggest it has some influence on inflammatory processes. [5]

Anthony Almada is a nutritional and exercise biochemist and has collaborated on more than 50 university-based clinical trials. He is the co-founder of EAS and founder and chief scientific officer of IMAGINutrition.