drug interactions

; DIs desirable or undesirable outcomes of the simultaneous administration of two or more drugs (i.e. those with narrow therapeutic indices or steep response curves) in 5% of patients who take three or more drugs daily; DIs occur as a result of mutual interaction, endogenous or exogenous chemical agents or dietary constituents; DI risk is increased in polypharmacy, use of prophylactic drug therapies or the severely ill

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