Yeah, there have actually been serious complaints in the medical community about the nomenclature. Sonic hedgehog was one of the first to receive specific attention. To quote the Nature article cited in wiki, "Some clinicians and scientists criticize giving genes frivolous, whimsical, or quirky names, calling it inappropriate that patients with "a serious illness or disability that they or their child have a mutation in a gene such as sonic hedgehog".

born_yesterday:If you want your work to have clinical applicability, act like it.

Yes, because the name of the gene is going to have such a profound effect on the treatment used on the patient. Telling anyone my age or younger that they had a mutation in sonic hedgehog would probably provide a much-needed laugh.