2-aminopyrimidinones and their 6-aza-analogs

In order to find the new potent CK2 inhibitors 60 derivatives of 2-aminopyrimidinones and their 6-aza-substituted analogs were synthesized and tested in vitro. Among them, the most efficient inhibitor 2-hydroxy-5-[4-(4-methoxyphenyl)-6-oxo-1,6-dihydropyrimidin-2-ylamino]benzoic acid was identified (IC50 = 1.1 μM). The structure-activity relationship study of newly synthesized derivatives was carried out and their binding mode with adenosine triphosphate-acceptor site of CK2 was proposed (Fig. 1).