In operation since 2008, the ATLAS experiment is the largest of all the experiments at the LHC. The ATLAS-MPX (MPX) detectors installed in ATLAS are based on the Medipix2 silicon pixelated detector which has been developed by the Medipix Collaboration at CERN to perform real-time imaging. They can be used for luminosity measurements. They were installed at sixteen different positions in the ATLAS cavern at the LHC in 2008. The MPX network successfully collected data independently of the ATLAS data recording chain from 2008 to 2013. Each MPX detector provides measurements of the integrated LHC luminosity. This thesis describes the technique for calibrating the luminosity data and performance of MPX detectors for measuring the luminosity in 2012. The calibration was performed via the van der Meer (vdM) scans technique which allows the measurement of the convolved beam sizes in the vertical and the horizontal planes at the ATLAS interaction point (IP1). The determination of the absolute luminosity requires a precise knowledge of the beam intensities and the number of beam bunches. A luminosity calibration constant was determined. The three calibration scans were analyzed and the results were cross-checked among the MPX detectors and other ATLAS sub-detectors specifically dedicated to luminosity measurement. The luminosity determined from the calibration scans was compared to the luminosity of regular runs before and after the vdM scans. The MPX network gives reliable information for the overall ATLAS luminosity determination over a wide dynamic range (luminosity from 5 × 10^29 cm−2 s−1 up to 7 × 10^33 cm−2 s−1).