Michelle’s research interests lie in epidemiological and biostatistical methods. Her work includes developing multivariate diagnostic and prognostic tools for evaluation of metabolic status, study design for nutrition interventions, and evaluation of risk factors for mining injuries. She plays a large role in supporting research across UI as a statistical consultant and in training master’s level statistics students in consulting.

The CHARGE study was a population based study to determine risk factors for autism. This study has recruited nearly 1,500 children and measured a vast array of environmental, biological, and genetic factors. Dr. Wiest’s research thus far has focused on a sub-population of approximately 200 subject on which 200 lipid metabolites were measured. Because this study is one of the few population based studies on both autistic and normal children, it is an excellent opportunity to define reference ranges for many different measurements.

Thus far, we have used univariate methods to detail reference ranges for each lipid metabolite. However, it is unlikely that one lipid metabolite being out of the reference range would be cause for concern. Therefore, we are working to define multivariate reference ranges based on the biochemical interconnection of the lipid metabolites, and graphical tools to visual them.

Modeling lipoprotein size and composition in response to dietary challenge

Abstract

Cholesterol levels in HDL and LDL are well established predictors of heart disease. They also react to certain foods, for instance, high saturated fat. However, it is not the level of HDL and LDL alone, but their size and composition which determines the risk of coronary disease. In collaboration with UC Davis and Harvard, we are modeling how the composition of the particle influences the size, which in turn relates to coronary disease risk.

Identifying risk factors for injury in underground metal mines

Abstract

We are working with local silver mines as well as federal databases to identify underlying risk factors for mining injuries and accidents. This involves multivariate modeling of the injury experience overall. We are also utilizing in-depth questionnaires to identify personal practices to relate back to miners’ injury history.

Outreach Projects

Women in Science, Fall 2009, 2010, Spring 2010

Women in Science is an invitational program for tenth-grade girls in northern Idaho. I am a keynote speaker and activity leader in both the Boise and Coeur d’Alene programs.

Kootenai Medical Center Clinical Research Roundtable, 2009 – present

The group consists of nurses, educators, medical librarians, and academic partners who meet the first Tuesday of every month to assist in Institutional Review Board proposal development, facilitation of research, and mentoring new researchers.

Micron STEM Education Research Initiative

This project, supported by major funding from the Micron Technology Foundation – is learning why some Idaho students may not perform well, or pursue careers, in the areas of science, technology, engineering and math (STEM) and developing educational programs based upon those findings

Awards and Honors

Outstanding Faculty Award, 2009

In recognition of exceptional support in assisting students with disabilities to achieve their academic goals.