System Message

ATM Monoclonal Antibody (C.74.4)

Performance guaranteed

Purchase with confidence, knowing that we stand behind
the performance of our antibodies with the InvitrogenTM
antibody performance guarantee. If an InvitrogenTM antibody
doesn't perform in your experiment as described on our website
or datasheet, we'll replace the product at no cost to you, or
if you prefer, we'll provide you with a credit for a future
purchase.*
Learn more.

* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the
product for use in their own experiment using appropriate negative and positive controls.

Product Specific Information

It is not recommended to aliquot this antibody.

Background/Target Information

The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.