Prescription pain medications (opioids) account for more fatal overdoses than any other prescription or illegal drug, including cocaine, heroin, and hallucinogens combined. The number of Ohio lives lost to unintentional drug overdose has risen from 369 lives in 1999 to 1,765 in 2011, a 440% increase! Prescription drugs are involved in most of the unintentional drug overdoses and have largely driven the rise in deaths. Opioids and multiple drug use are the largest contributors to the epidemic.