1Section of Pulmonary and Critical Care Medicine, Department of Medicine, University of Chicago, Chicago, Ill, USA.

Abstract

BACKGROUND:

The genetic mechanisms underlying asthma remain unclear. Increased permeability of the microvasculature is a feature of asthma, and the sphingosine-1-phosphate receptor (S1PR1) is an essential participant regulating lung vascular integrity and responses to lung inflammation.

OBJECTIVE:

We explored the contribution of polymorphisms in the S1PR1 gene to asthma susceptibility.

Plots of association p-values of tested S1PR1 tSNPs with asthma and severe asthma in (A) European Americans from Chicago, (B) African Americans from Chicago, and (C) African Americans from New York. Dashed line represents a p-value of 0.05. The S1PR1 gene structure indicating the relative position of tested tSNPs for association is depicted in the bottom of the figure.