Nutritional supplements were associated with a reduced risk of progressive neovascular age-related macular degeneration, according to the Age-Related Eye Disease Study; however, the supplements did not reduce the risk of geographic atrophy.AREDS included 4,757 patients; 3,549 patients took part in an epidemiologic follow-up study, which reported 10-year outcomes. The study featured a formulation comprising 500 mg of vitamin C, 400 IU of vitamin E, 15 mg of beta-carotene, 80 mg of zinc and 2 mg of copper.