A unicuspid aortic valve is a rare pathology among congenital heart diseases that requires cardiac surgery and is often confused with a bicuspid valve. The incidence of unicuspid aortic valve on echocardiography was reported to be 0.02% in adults. It usually presents with aortic stenosis and/or aortic regurgitation. Other cardiovascular complications, such as aortic dilatation, patent ductus arteriosus, coarctation of aorta, ventricular septal defect, and left ventricular hypertrophy, can accompany it. Herein, we present a case report of a 33-year-old asymptomatic male patient with a unicuspid aortic valve complicated by coarctation of the aorta and an ascending aorta aneurysm. The first stage operation, bypass with an artificial blood vessel between the right axillary artery and right femoral artery combined with aortic valve repair using the tricuspidization technique and aortic arch wrapping, was successful. During the surgery, the valve was found to be an acommissural unicuspid aortic valve without significant calcification and thickening. A second stage operation of a distal arch to descending thoracic aorta bypass was followed, successfully without complication.

PURPOSE: To observe the effect of subcutaneous ectopic osteogenesis using different proportional mixtures of hydroxyapatite (HAP) and human mandible in nude mice.METHODS: After obtaining external oblique ridge of mandible, autologous bone was mixed with HAP according to certain proportion. The mixtures were divided into 5 groups (group A: autologous bone/HAP=2/1; Group B: autologous bone/HAP=1/1; Group C: autologous bone/HAP=1/2; Group D: autologous bone/HAP=a quarter; Group E: HAP). The 5 groups of mixtures were respectively implanted into nude mice subcutaneously. After 8 weeks, the specimens were obtained and hard tissue sections were completed. The new bone formation was measured after trinitrophenol staining. The data was analyzed with SPSS 13.0 software package.RESULTS: The hard tissue section showed that new ectopic bone formation area was 9.1% (Group A), 16.1% (Group B), 6.1% (Group C), 3.8% (Group D), and 1.3% (Group E), respectively. New bone formation was the most in group B, while it was the least in group E. Significant differences were found between group B and other groups(P<0.05). However, there was no significant difference between group E and group C or D (P>0.05). The retention rate of HAP was the most in group E (30.3%) and the least (16.3%) in group A.CONCLUSIONS: During 8 weeks, human autologous bone mixed with HAP helps new bone formation in nude mice. The best ratio autologous bone and HAP was 1:1. This study provides certain reference basis for dentist to make lifting surgery outside the maxillary sinus using artificial bone graft. Supported by Science and Technology Project of Ningxia Hui Autonomous Region (2011zys271).