He claims his Pittsburgh lab Cybergenetics, which helped identified 9/11 victims, can routinely unlock the kind of samples the FSS struggled with.

The latest episode of Nine News's Maddie podcast reveals detectives on Scotland Yard's Operation Grange probe were told a year ago of Dr Perlin's advanced techniques and his offer to re-test samples - but did not respond.

Further enquiries about Dr Perlin's offer by Nine.com.au last week also went unanswered, the site claims.

Successful analysis of the DNA could potentially transform the world's most famous missing person's case by confirming or conclusively ruling out key lines of enquiry.

SWAB TEST 'TOO COMPLEX'

One crucial swab was from the boot of a silver Renault Scenic that Kate and Gerry McCann leased 25 days after Madeleine vanished in Praia da Luz.

Dr Lowe told Portuguese police at the time: "Let's look at the question that is being asked. "Is there DNA from Madeleine on the swab?

"It would be very easy to say 'Yes' simply because of the number of [DNA] components within the result that are also in her reference sample."

Ultimately, Dr Lowe said the FSS could not answer that critical question because the lab was unable to separate a mix of DNA components from at least three people

Dr Perlin, who has worked with police forces around the world, claims his advanced computer software can interpret complex results like these in a way that was not possible in 2007.

He told Nine's podcast investigation: "If a lab can produce informative data, even if it is complex and mixed, but they can't interpret it then you can have tremendous injustice - of guilty people not being convicted, or innocent people staying in prison.

"What is needed is an objective and accurate interpretation that can scientifically resolve the DNA."

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