MMC100

Metabolic Cage

For Use With Mice

The MMC100 Metabolic Cage for use with mice is a free-standing unit designed
to accommodate a single mouse for up to a 24 hour period. The cage utilizes a unique blend of
features to maximize uncontaminated urine collection.

Cage Features

Easy to use, assemble, and clean

Accurately separates urine from feces

Few components and consumables

Constructed from durable, impact resistant acrylic

Stainless steel screen floor and collection funnel

O-ring seals for rigid connections

Visual clarity for observation

Provides 2-5ml collection in a 24 hour period

Urine vessel is removable and disposable.

Conforms to recommendations set forth in the Guide for the Care and Use of Laboratory Animals

Optional Obese and Chiller System Design

The MMC100 Metabolic Cage is manufactured from stainless steel and acrylic components making the cage
light weight and rust resistant. Assembly takes less than a minute since there are only eight components,
which are as follows:

Components

Top Cylinder

Bottom Cylinder

Screen Floor

Collection Funnel

Lid Assembly

Food and Water Holders

Urine Collection Vessel

For instructions on how to assemble the MMC100 Metabolic Cage, please visit the
Downloads page.

Collection Process

The key to the Metabolic Cage’s high collection rate is the funnel. It captures the urine
droplets from the mouse, slowly gathering the liquid on the bulb until enough is present to
fall into the collection vessel below. Any extraneous matter that is not impeded by the screen floor,
is diverted by the funnel’s walls and shape, inhibiting the material from entering the collection vessel.
The outcome is a full, clean sample.

The Metabolic Cage is beneficial for a variety of studies, including (but not limited to):

Effects of drug therapies

Renal function studies

Urinary protein excretion

Daily food and water intake

Phenotyping

Evaluation of standard or intervened metabolic function

Urinary excretion volume

The cage can also be modified to accommodate obese mice and/or to include insulated bases for integrating
with the CCS2000 Chiller System.

Obese Design

There is one difference between the standard Metabolic Cage and the obese design: the arms of the top cylinder
sit at a 45˚ angle making the food and water holders easily accessible to overweight mice. The holders are also
modified to sit inside the angled arms, as pictured below.

The obese design includes the same features as previously mentioned for the standard design.
In addition, while originally designed for obese mice, this cage can also be used with standard mice.

Obese Design Holders

Chiller System Design

Similar to the obese design, the Chiller System Metabolic Cage is almost identical to the standard Metabolic Cage.
The only variation is in the bottom cylinder. It is divided into two pieces to include the insulated cage base
and base plugs to connect to the Chiller System.

This cage provides a convenient method for maintaining sample temperatures at or below 45˚F (7˚C)
throughout the collection process. For more information on how Chiller System, please visit the
CCS2000 page.