Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )

Length:

128

Sequences:

620

Seq/Len:

4.84

HH_delta:

0.515 (20Jul13)

GREMLIN Results:
Residue pairs sorted by strength in covariance:Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

i

j

Raw Score

Scaled Score

15_Y

55_D

0.24682

2.556

28_F

33_F

0.20814

2.156

23_W

28_F

0.20526

2.126

12_P

41_I

0.20119

2.084

55_D

58_K

0.17647

1.828

8_D

45_R

0.17174

1.779

23_W

33_F

0.16793

1.739

26_H

33_F

0.16228

1.681

23_W

27_P

0.15917

1.648

38_Q

42_E

0.15714

1.627

23_W

26_H

0.15413

1.596

20_D

44_L

0.15219

1.576

3_K

14_M

0.14349

1.486

74_K

77_A

0.14152

1.466

15_Y

58_K

0.13765

1.426

54_I

59_S

0.13271

1.374

55_D

97_A

0.12757

1.321

20_D

51_E

0.1264

1.309

41_I

52_V

0.12608

1.306

71_A

77_A

0.12586

1.303

7_V

10_L

0.12532

1.298

31_Q

49_I

0.12483

1.293

22_S

49_I

0.12251

1.269

21_R

49_I

0.12062

1.249

10_L

13_G

0.11979

1.241

7_V

25_E

0.11829

1.225

20_D

49_I

0.11823

1.224

68_P

71_A

0.11584

1.200

22_S

26_H

0.11492

1.190

76_A

79_P

0.11294

1.170

12_P

35_I

0.11189

1.159

24_L

108_V

0.10945

1.134

54_I

112_F

0.10808

1.119

19_L

44_L

0.1062

1.100

112_F

115_V

0.1054

1.092

119_K

122_D

0.10501

1.088

122_D

125_P

0.10501

1.088

75_Q

89_S

0.10478

1.085

68_P

76_A

0.10452

1.082

79_P

86_K

0.10416

1.079

52_V

125_P

0.10414

1.079

44_L

52_V

0.10368

1.074

75_Q

79_P

0.10353

1.072

42_E

46_R

0.10328

1.070

93_E

97_A

0.10136

1.050

21_R

30_F

0.1002

1.038

51_E

93_E

0.0999

1.035

24_L

27_P

0.09968

1.032

73_A

86_K

0.0994

1.029

73_A

77_A

0.09913

1.027

15_Y

34_L

0.09862

1.021

21_R

26_H

0.09841

1.019

53_Y

104_A

0.09818

1.017

19_L

53_Y

0.09789

1.014

89_S

122_D

0.09759

1.011

31_Q

40_D

0.0972

1.007

69_P

73_A

0.09695

1.004

70_E

74_K

0.09574

0.992

19_L

34_L

0.09562

0.990

92_E

95_R

0.09545

0.989

48_G

123_V

0.09491

0.983

28_F

119_K

0.09485

0.982

46_R

57_D

0.09437

0.977

16_V

19_L

0.09407

0.974

20_D

26_H

0.09355

0.969

97_A

100_L

0.0932

0.965

69_P

79_P

0.09305

0.964

68_P

77_A

0.09262

0.959

42_E

92_E

0.09233

0.956

4_K

51_E

0.09204

0.953

111_L

126_A

0.09201

0.953

27_P

33_F

0.0915

0.948

67_P

70_E

0.09123

0.945

21_R

112_F

0.09111

0.944

36_K

104_A

0.09101

0.943

98_E

105_K

0.09091

0.942

21_R

27_P

0.09084

0.941

23_W

116_R

0.09075

0.940

62_V

68_P

0.08963

0.928

23_W

40_D

0.08959

0.928

15_Y

97_A

0.08902

0.922

100_L

108_V

0.08859

0.917

93_E

96_R

0.08835

0.915

26_H

47_L

0.08832

0.915

21_R

33_F

0.08826

0.914

19_L

97_A

0.08803

0.912

32_G

49_I

0.088

0.911

67_P

76_A

0.08784

0.910

110_S

114_D

0.08753

0.907

25_E

33_F

0.08745

0.906

5_I

37_S

0.08735

0.905

6_P

12_P

0.08728

0.904

5_I

13_G

0.08723

0.903

20_D

53_Y

0.08683

0.899

17_S

56_P

0.08621

0.893

75_Q

78_P

0.08612

0.892

73_A

76_A

0.08608

0.892

55_D

93_E

0.08539

0.884

21_R

35_I

0.08466

0.877

123_V

126_A

0.08454

0.876

100_L

118_G

0.0845

0.875

11_K

42_E

0.08416

0.872

7_V

48_G

0.08415

0.872

19_L

23_W

0.08415

0.872

67_P

71_A

0.0838

0.868

26_H

31_Q

0.08338

0.864

14_M

97_A

0.08324

0.862

26_H

32_G

0.08259

0.855

86_K

95_R

0.08218

0.851

93_E

121_I

0.08196

0.849

34_L

125_P

0.0816

0.845

7_V

35_I

0.08134

0.842

24_L

94_L

0.08073

0.836

33_F

49_I

0.08071

0.836

47_L

112_F

0.08046

0.833

36_K

78_P

0.08037

0.832

71_A

76_A

0.08034

0.832

118_G

121_I

0.08009

0.829

28_F

40_D

0.07981

0.827

16_V

41_I

0.0796

0.824

16_V

36_K

0.07954

0.824

67_P

86_K

0.07951

0.823

17_S

58_K

0.07945

0.823

26_H

49_I

0.07936

0.822

69_P

75_Q

0.07889

0.817

24_L

103_E

0.07868

0.815

8_D

102_Q

0.07847

0.813

12_P

38_Q

0.07841

0.812

23_W

45_R

0.07838

0.812

54_I

93_E

0.07831

0.811

58_K

61_D

0.07823

0.810

53_Y

105_K

0.07821

0.810

49_I

100_L

0.07778

0.806

10_L

41_I

0.07766

0.804

107_V

111_L

0.0775

0.803

100_L

122_D

0.07742

0.802

66_K

70_E

0.07738

0.801

20_D

101_Y

0.0773

0.801

19_L

105_K

0.07724

0.800

70_E

77_A

0.07723

0.800

6_P

9_Q

0.07669

0.794

71_A

75_Q

0.07663

0.794

97_A

121_I

0.07634

0.791

114_D

117_A

0.07625

0.790

37_S

106_Q

0.07589

0.786

110_S

123_V

0.07527

0.780

24_L

28_F

0.07513

0.778

8_D

111_L

0.07508

0.778

33_F

40_D

0.075

0.777

20_D

47_L

0.07495

0.776

5_I

11_K

0.07492

0.776

100_L

105_K

0.07489

0.776

15_Y

37_S

0.07449

0.771

47_L

59_S

0.07436

0.770

90_L

94_L

0.07399

0.766

41_I

106_Q

0.07398

0.766

60_R

107_V

0.07381

0.764

3_K

61_D

0.07377

0.764

51_E

56_P

0.07367

0.763

70_E

73_A

0.07334

0.760

24_L

102_Q

0.07328

0.759

43_K

47_L

0.07315

0.758

21_R

28_F

0.07306

0.757

47_L

119_K

0.07306

0.757

34_L

58_K

0.07305

0.757

67_P

125_P

0.07299

0.756

15_Y

33_F

0.07297

0.756

68_P

75_Q

0.07288

0.755

19_L

22_S

0.07274

0.753

74_K

79_P

0.07267

0.753

39_A

71_A

0.07266

0.753

15_Y

20_D

0.07259

0.752

69_P

102_Q

0.07245

0.750

Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.

HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits: Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)