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Set against the backdrop of a circus, the show focuses on Littlechap, from the moment of his birth to his death. Each time something unsatisfactory happens, he calls out 'Stop the world!' and addresses the audience. After being born, going through school, and finding work as a tea-boy, his first major step towards improving his lot is to marry Evie, his boss's daughter, after getting her pregnant out of wedlock. Saddled with the responsibilities of a family, he is given a job in his father-in-law's factory. He has two daughters, Susan and Jane, but truly longs for a son. He allows his growing dissatisfaction with his existence to lead him into the arms of various women in his business travels—Russian official Anya, German domestic Ilse, and American cabaret singer Ginnie—as he searches for something better than he has. He becomes rich and successful, and is elected to public office. Only in his old age does he realize that what he always had—the love of his wife— was more than enough to sustain him. Evie dies, however, and writing his memoirs, Littlechap comes to terms with his own selfishness. At the moment of his death, however, he watches his second daughter give birth to a son. When the boy nearly dies, Littlechap intervenes, and allows Death to take him instead. He then mimes his own birth, beginning the cycle once again.

Producer David Merrick, always impressed by a low-cost project requiring minimal sets, costumes, and a small cast, decided to stage the show in New York City. It was directed by Newley, and featured scenery and lighting design by Sean Kenny, musical supervision by Ian Fraser, musical direction by Milton Rosenstock, orchestrations by Ian Fraser. After one preview, the Broadway production opened on 3 October 1962 at the Shubert Theatre, eventually transferring to the Ambassador to complete its 555-performance run. Newley and Quayle reprised their London roles. Newley later was replaced by Kenneth Nelson, then Joel Grey, and Joan Eastman assumed the roles of Evie et al. A Broadway cast recording was released by Polydor.[3] On the national company tour, the show starred Grey and Julie Newmar.