Bottom Line:
A second locus (rs148760487 at 2q24.2) was associated at genome-wide statistical significance in initial analyses; the association was similar in ER-positive and ER-negative case patients.Here the results of genotyping suggested that the finding was less robust.Our results have potential clinical implications, as they confirm that germline genotype can provide prognostic information in addition to standard tumor prognostic factors.

Figure 2: Quantile-Quantile (Q-Q) plot for the combined GWAS and COGS analyses for estrogen receptor (ER)–negative cases. The y-axis represents the observed -log10P value, and the x-axis represents the expected -log10P value. The red line represents the expected distribution under the hypothesis of no association. All statistical tests were two-sided.

Figure 2: Quantile-Quantile (Q-Q) plot for the combined GWAS and COGS analyses for estrogen receptor (ER)–negative cases. The y-axis represents the observed -log10P value, and the x-axis represents the expected -log10P value. The red line represents the expected distribution under the hypothesis of no association. All statistical tests were two-sided.

Bottom Line:
A second locus (rs148760487 at 2q24.2) was associated at genome-wide statistical significance in initial analyses; the association was similar in ER-positive and ER-negative case patients.Here the results of genotyping suggested that the finding was less robust.Our results have potential clinical implications, as they confirm that germline genotype can provide prognostic information in addition to standard tumor prognostic factors.