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Perez succeeded in blocking Republican-backed voting laws in South Carolina and Texas that his division deemed racially discriminatory. He pressed racial profiling charges against Joe Arpaio, the Republican sheriff of Maricopa County, Ariz., who is among the most divisive figures in the national immigration debate. His handling of a legal agreement with the city of St. Paul, Minn., in a lending discrimination case has drawn condemnation from Sen. Charles E. Grassley of Iowa, the top Republican on the Judiciary Committee, who has called it a "quid pro quo" and a "shady deal."

Senate criticism of Perez so far has come primarily from Grassley and the Judiciary Committee, which oversees the Justice Department and is seen as one of the more-partisan panels in the chamber. Perez's nomination to the Labor Department will not come before the Judiciary Committee, however. It will come before the Health, Education, Labor and Pensions Committee, where Sen. Lamar Alexander of Tennessee is the top Republican.