Section of Infectious Diseases, Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut.

2

Section of Geriatrics, Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut.

3

Yale Center for Analytical Sciences, Department of Biostatistics, Yale School of Public Health, New Haven, Connecticut.

Abstract

Importance:

Bacteriuria plus pyuria is highly prevalent among older women living in nursing homes. Cranberry capsules are an understudied, nonantimicrobial prevention strategy used in this population.

Objective:

To test the effect of 2 oral cranberry capsules once a day on presence of bacteriuria plus pyuria among women residing in nursing homes.

Design, Setting, and Participants:

Double-blind, randomized, placebo-controlled efficacy trial with stratification by nursing home and involving 185 English-speaking women aged 65 years or older, with or without bacteriuria plus pyuria at baseline, residing in 21 nursing homes located within 50 miles (80 km) of New Haven, Connecticut (August 24, 2012-October 26, 2015).

Interventions:

Two oral cranberry capsules, each capsule containing 36 mg of the active ingredient proanthocyanidin (ie, 72 mg total, equivalent to 20 ounces of cranberry juice) vs placebo administered once a day in 92 treatment and 93 control group participants.

Main Outcomes and Measures:

Presence of bacteriuria (ie, at least 105 colony-forming units [CFUs] per milliliter of 1 or 2 microorganisms in urine culture) plus pyuria (ie, any number of white blood cells on urinalysis) assessed every 2 months over the 1-year study surveillance; any positive finding was considered to meet the primary outcome. Secondary outcomes were symptomatic urinary tract infection (UTI), all-cause death, all-cause hospitalization, all multidrug antibiotic-resistant organisms, antibiotics administered for suspected UTI, and total antimicrobial administration.

Bi-monthly and Overall Adjusted Percentages of Bacteriuria Plus Pyuria Specimens by Treatment Status (N=185)aa Percentage with bacteriuria plus pyuria and corresponding 95% confidence intervals were adjusted for the following pre-specified baseline variables: bacteriuria, incontinence, age at enrollment, and number of comorbidities (see for additional details). The baseline and bi-monthly data represent study participants with bacteriuria plus pyuria while the overall data represent all specimens of bacteriuria plus pyuria over the six follow-up time points (months 2-12). See Total number of participants contributing data at each time point in .