Hematological and Infectious Diseases laboratory

Souichi Adachi M.D., Ph.D. Professor

Many hematologic malignancies of children have been cured because of progression of treatments including chemotherapy and stem cell transplantation. But, still some of these patients relapse or suffer from serious complications. Our laboratory has many projects related with new treatments or diagnostic tools in these patients. We are collaborating with Kyoto University Hospital and other major Universities and Hospitals through Japanese Pediatric Leukemia/Lymphoma Study Group (JPLSG).

Research and Education

Our main projects are as follows;

Mechanism of new type of cell death of leukemic cells in vitro and in vivo induced by molecular target therapy

Development of new treatments and new prognostic factors in child AML

Analysis of mechanism of enhancement of neutrophil killing activity against multi-drug resistant bacteria by intravenous immunoglobulin

Analysis of minimal residual disease of leukemia by FACS and analysis of leukemic stem cells in this population

Analysis of serious complications in patients after stem cell transplantation.

We analyse autophagy in leukemic cells (1) and neutrophils (3). When autophagy is inhibited leukemic cells are dead and neutrophils are survived. Thus autophagy is very interesting and important cell death mechanism. We analyse samples from patients in these projects approved by IRB by Kyoto University Hospital. We try to develop new treatments for relapsed and refractory leukemic patients.