DanStem Seminar by Irene Miguel-Aliaga

Internal organs constantly exchange signals, and can respond with profound anatomical and functional adaptations, even in fully developed organisms. Such organ plasticity results from a need to integrate and respond to both environmental information and internal state, and is key to maintaining homeostasis and driving adaptive changes. Miguel-Aliaga group is interested in understanding the mechanisms by which organs sense and respond to change: the molecules, cellular events and physiological adaptations involved. The intestine and its neurons are a fantastic system with which to tackle these questions. Their main experimental system is Drosophila melanogaster, but they are beginning to explore the evolutionary conservation of some of their findings in mice and humans through local and international collaborations