ALEXANDRIA, Va.—A federal jury was set to begin deliberations in the case against former Trump campaign chairman Paul Manafort, as prosecutors made their final pitch to jurors that Mr. Manafort was a liar who cheated the government on his taxes and bilked banks on fraudulent loans to help pay for a life of expensive suits, luxury cars and manicured hedges.

“Mr. Manafort lied to keep more money when he had it, and to get more money when he didn’t,” prosecutor Greg Andres told jurors Wednesday as he summed up the case.

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