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What is NACE®?

Human beings have 23 pairs of chromosomes, a total of 46 (two copies for each pair). The first 22 pairs are numbered 1 to 22. The last pair determines the gender. Girls have two X chromosomes and boys have an X chromosome and a Y chromosome. When a chromosome is missing or there is an extra one health and developmental problems appear. When there is an extra copy of a chromosome, in other words, three copies instead of two, it is referred to as trisomy.

What is NACE?

NACE is a non-invasive prenatal screening test that analyzes the most frequent chromosomal alterations without compromising the pregnancy.

NACE is a complete prenatal test to detect anomalies in chromosomes 21, 18, and 13 (Down, Edwards, and Patau syndromes). It also detects the most common anomalies in the sexual chromosomes (X and Y)*.

A simple peripheral blood extraction from the mother allows free DNA circulating in the maternal plasma to be detected via next generation sequencing technology and advanced bioinformatic analysis.

NACE has the highest informativeness rate in the market: we obtain results for 99.9% of the analyzed samples.

*Except for twin pregnancies.

What is NACE Extended 24?

NACE Extended 24 has the same characteristics as the NACE test, but is an extended version that also incorporates the detection of all 24 chromosomesand identifies five microdeletions which are associated with major genetic syndromes: DiGeorge syndrome, 1p36 deletion syndrome, Angelman syndrome**, Prader-Willi syndrome**, Cri-du-chat syndrome, and Wolf-Hirschhorn syndrome..

Microdeletions are chromosomal disorders caused by small losses in chromosomal material. Most occur by chance, without a family history or other risk factors such as advanced maternal age. These syndromes are generally associated with intellectual disability and malformation of different organs.

It is validated for single pregnancies with a gestational age of at least 10 weeks.

**The microdeletion region is the same for both Angelman and Prader-Willi syndromes (15q11.2). The NACE Extended 24 test does not distinguish between the two syndromes. An additional test will be required to confirm the syndrome in question.