Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )

Length:

92

Sequences:

516

Seq/Len:

5.61

HH_delta:

0.935 (20Jul13)

GREMLIN Results:
Residue pairs sorted by strength in covariance:Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

i

j

Raw Score

Scaled Score

42_P

46_F

0.45079

3.022

5_R

57_D

0.37285

2.500

16_S

47_L

0.32753

2.196

25_M

28_K

0.30442

2.041

26_P

30_L

0.30032

2.013

59_A

69_T

0.29699

1.991

24_A

37_V

0.26728

1.792

10_A

82_T

0.26465

1.774

28_K

37_V

0.24921

1.671

25_M

29_Y

0.24869

1.667

37_V

41_G

0.23662

1.586

11_I

15_I

0.23083

1.548

13_E

16_S

0.22582

1.514

46_F

49_M

0.22571

1.513

72_A

85_F

0.22487

1.508

55_A

72_A

0.22359

1.499

38_K

42_P

0.22024

1.477

66_L

70_L

0.20231

1.356

10_A

86_E

0.19228

1.289

57_D

61_K

0.19135

1.283

25_M

40_I

0.18862

1.265

71_L

89_L

0.18784

1.259

4_R

7_R

0.18679

1.252

58_L

62_Y

0.18383

1.232

36_A

39_I

0.17981

1.206

27_L

31_A

0.17975

1.205

72_A

89_L

0.17888

1.199

35_E

39_I

0.17796

1.193

26_P

31_A

0.17472

1.171

13_E

21_L

0.17371

1.165

6_F

10_A

0.16873

1.131

14_G

83_F

0.16783

1.125

69_T

73_L

0.1665

1.116

30_L

91_R

0.16638

1.115

56_L

60_S

0.16371

1.098

17_L

78_I

0.1624

1.089

28_K

41_G

0.15901

1.066

52_L

56_L

0.15743

1.055

21_L

37_V

0.15659

1.050

23_I

27_L

0.15614

1.047

87_R

91_R

0.15351

1.029

49_M

53_V

0.15302

1.026

53_V

57_D

0.15247

1.022

39_I

42_P

0.14859

0.996

15_I

83_F

0.14839

0.995

17_L

76_S

0.148

0.992

24_A

28_K

0.14793

0.992

9_I

54_A

0.14643

0.982

53_V

91_R

0.14287

0.958

6_F

86_E

0.14272

0.957

20_L

37_V

0.14239

0.955

10_A

75_A

0.14204

0.952

6_F

51_Y

0.14177

0.950

17_L

82_T

0.14073

0.944

12_L

47_L

0.14054

0.942

14_G

75_A

0.13948

0.935

59_A

78_I

0.13886

0.931

67_K

70_L

0.13874

0.930

18_L

23_I

0.13799

0.925

3_L

68_R

0.13779

0.924

55_A

73_L

0.13729

0.920

18_L

83_F

0.13721

0.920

5_R

50_L

0.13533

0.907

34_P

37_V

0.13466

0.903

80_F

84_W

0.13229

0.887

9_I

50_L

0.13187

0.884

26_P

34_P

0.13144

0.881

24_A

36_A

0.13043

0.874

18_L

80_F

0.1301

0.872

88_W

91_R

0.12978

0.870

26_P

29_Y

0.12949

0.868

18_L

24_A

0.12946

0.868

55_A

69_T

0.12625

0.846

60_S

63_R

0.1255

0.841

70_L

77_V

0.12509

0.839

81_G

86_E

0.12497

0.838

48_F

76_S

0.12377

0.830

19_L

40_I

0.12252

0.821

76_S

81_G

0.12004

0.805

19_L

36_A

0.11958

0.802

5_R

58_L

0.11921

0.799

51_Y

89_L

0.1189

0.797

39_I

43_I

0.11879

0.796

14_G

63_R

0.11872

0.796

17_L

21_L

0.11804

0.791

71_L

85_F

0.11766

0.789

20_L

24_A

0.11601

0.778

59_A

75_A

0.1156

0.775

84_W

87_R

0.11511

0.772

52_L

61_K

0.11343

0.760

52_L

77_V

0.11342

0.760

24_A

41_G

0.11341

0.760

78_I

82_T

0.11331

0.760

2_A

57_D

0.11289

0.757

23_I

26_P

0.1122

0.752

6_F

16_S

0.11141

0.747

19_L

91_R

0.11077

0.743

33_N

36_A

0.11038

0.740

21_L

26_P

0.11012

0.738

20_L

34_P

0.10971

0.736

27_L

34_P

0.1095

0.734

8_V

90_R

0.10924

0.732

20_L

25_M

0.10764

0.722

16_S

41_G

0.10747

0.721

17_L

77_V

0.10743

0.720

10_A

59_A

0.1072

0.719

51_Y

75_A

0.10693

0.717

2_A

65_S

0.10659

0.715

38_K

41_G

0.10657

0.714

31_A

34_P

0.1064

0.713

35_E

38_K

0.10578

0.709

4_R

53_V

0.10576

0.709

8_V

87_R

0.10529

0.706

42_P

49_M

0.1052

0.705

67_K

87_R

0.10461

0.701

10_A

17_L

0.10427

0.699

4_R

84_W

0.10394

0.697

27_L

42_P

0.10369

0.695

65_S

68_R

0.10337

0.693

13_E

48_F

0.10325

0.692

24_A

34_P

0.10316

0.692

51_Y

79_P

0.10301

0.691

51_Y

59_A

0.10277

0.689

51_Y

86_E

0.10277

0.689

61_K

65_S

0.10248

0.687

11_I

46_F

0.10219

0.685

43_I

46_F

0.1019

0.683

63_R

66_L

0.10172

0.682

19_L

46_F

0.10171

0.682

52_L

74_L

0.10129

0.679

78_I

83_F

0.10105

0.677

52_L

75_A

0.10082

0.676

58_L

86_E

0.09935

0.666

85_F

89_L

0.09894

0.663

Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.