Old Molecule, New Use – Rebamipide

Rebamipide, which is an amino acid derivative of 2-(1H)-quinolinone, is commonly used for mucosal protection, treatment of gastritis and healing of gastroduodenal ulcers.

In a study published recently, in the Indian Journal of Dermatology, the researchers found that rebamipide can be used as an effective treatment for aphthous ulcers and other realted condtions.

MOA: Rebamipide acts by several mechanisms like, causing a reduction in oxygen radicals, increasing the production of protective protagladins and improving blood flow in the mucosa of the ulcer

Adverse Reactions of Rebamipide: Rebamipide can cause side effects such as pruritus, nausea, mild to moderate form of skin rashes, constipation and diarrhoea,

Precautions: Rebamipide should not be used by the elderly, children and adult patients suffering from chronic illness including cancer. Patients who are hypersensitive to dyes, chemicals and synthetic formulations should not be prescribed Rebamipide.