Species

Arshad Rahman

Summary

Affiliation: University of Rochester

Country: USA

Publications

Hug tightly and say goodbye: role of endothelial ICAM-1 in leukocyte transmigration

Arshad RahmanDepartment of Pediatrics Neonatology, Lung Biology and Disease Program, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USAAntioxid Redox Signal 11:823-39. 2009

Fabeha FazalDepartment of Pediatrics Neonatology, Lung Biology and Disease Program, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USAJ Biol Chem 284:21047-56. 2009

Mohd MinhajuddinDepartment of Pediatrics Neonatology, Lung Biology and Disease Program, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USAJ Biol Chem 284:4052-61. 2009

Detail Information

Publications30

Hug tightly and say goodbye: role of endothelial ICAM-1 in leukocyte transmigration

Arshad RahmanDepartment of Pediatrics Neonatology, Lung Biology and Disease Program, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USAAntioxid Redox Signal 11:823-39. 2009

..This review summarizes our current understanding of the "ICAM-1 paradigm" of TEM with an emphasis on the signaling events mediating ICAM-1 expression and activated by ICAM-1 engagement in endothelial cells...

Fabeha FazalDepartment of Pediatrics Neonatology, Lung Biology and Disease Program, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USAJ Biol Chem 284:21047-56. 2009

..Together, these data show that cofilin-1 occupies a central position in RhoA-actin pathway mediating nuclear translocation of RelA/p65 and expression of ICAM-1 in endothelial cells...

Mohd MinhajuddinDepartment of Pediatrics Neonatology, Lung Biology and Disease Program, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USAJ Biol Chem 284:4052-61. 2009

..Thus, these data reveal an important role of PKC-delta and PI3K/Akt pathways in activating mTOR as an endogenous modulator to ensure a tight regulation of NF-kappaB signaling of ICAM-1 expression in endothelial cells...

Randall S FreyDepartment of Pharmacology and Center for Lung and Vascular Biology, The University of Illinois College of Medicine, Chicago, Illinois 60612, USAJ Biol Chem 281:16128-38. 2006

..Thus, PI3Kgamma lies upstream of PKCzeta in the endothelium, and its activation is crucial in signaling NADPH oxidase-dependent oxidant production and subsequent NF-kappaB activation and ICAM-1 expression...

Arshad RahmanDepartment of Pharmacology, College of Medicine, The University of Illinois, Chicago, Ill 60612 7343, USACirc Res 91:398-405. 2002

..These results support a model in which ligation of PAR-1 induces NF-kappaB activation and ICAM-1 transcription by the engagement of parallel Galphaq/PKC-delta and Gbetagamma/PI3-kinase pathways that converge at Akt...

..The rapid ICAM-1 expression represents a novel mechanism for promoting the stable adhesion of PMN to endothelial cells that is needed to facilitate the early-onset transendothelial migration of PMN...

..Thus, PKCdelta is activated during engagement of the IFN-gamma receptor and plays an important role in IFN-gamma signaling by mediating serine phosphorylation of Stat1 and facilitating transcription of IFN-gamma-stimulated genes...

..These data demonstrate a novel function of PKCzeta in signaling oxidant generation in endothelial cells by the activation of NADPH oxidase, which may be important in mediating endothelial activation responses...

Role of NADPH oxidase in the mechanism of lung neutrophil sequestration and microvessel injury induced by Gram-negative sepsis: studies in p47phox-/- and gp91phox-/- mice

..The results support the model that initial engagement of CD18 integrins enables the further recruitment of additional PMN into lung tissues such that PMN continue to sequester and migrate after E. coli challenge...

Protein kinase C-delta (PKC-delta ) is activated by type I interferons and mediates phosphorylation of Stat1 on serine 727

..Altogether, these findings indicate that PKC-delta functions as a serine kinase for Stat1 and an upstream regulator of the p38 MAP kinase and plays an important role in the induction of Type I IFN-biological responses...