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Lyle Russell Cedric “Skitch” Henderson (January 27, 1918 – November 1, 2005) was a pianist, conductor, and composer. His nickname ("Skitch") reportedly derived from his ability to quickly "re-sketch" a song in a different key.

Skitch Henderson was born on a farm near Halstad, Minnesota, to Joseph and Josephine Henderson, both of Norwegian descent. His mother died shortly after his birth, and he was then sent to live with his Aunt Hattie, who raised him. She taught him piano, starting at the age of four. Although he didn't receive formal conservatory education in music, Henderson received classical training under Fritz Reiner, Albert Coates, Arnold Schoenberg, Ernst Toch and Arturo Toscanini, who invited him to conduct the NBC Symphony Orchestra. Henderson would later recount his learning the ropes by playing in taverns with popular singers of the day.

He started his professional career in the 1930s playing piano in the roadhouses of the American Midwest, his major break being as an accompanist on a 1937 MGM promotional tour featuring Judy Garland and Mickey Rooney. Henderson later said that as a member of MGM's music department, he worked with Garland to learn "Over the Rainbow" during rehearsals for The Wizard of Oz and played piano for her first public performance of the song at a local nightclub before the film was finished. However this account is at odds with the memoirs of the tune's composer, Harold Arlen, who said he first performed the song for the 14-year-old Garland.