BiOS Licensed Patents Inventory

The technology covered by these patent documents is available for
non-exclusive use by any entity that agrees to and conforms to the terms of a
BiOS
License.

A BiOS license allows both research and commercial use, and potential sharing
of improvements among all licensees.

The BiOS license further allows licensees to use improvements and requires
non-assertion of intellectual property covering improvements used by other
licensees. Use of associated materials and knowhow is made available under an
associated BiOS Technology Support Agreement, which sets voluntary contribution
fees for users.

Biological Gene Transfer System for Eukaryotic Cells
(TransBacter™) This invention relates generally to technologies for the
transfer of nucleic acids molecules to eukaryotic cells. In particular
non-pathogenic species of bacteria that interact with plant cells are used to
transfer nucleic acid sequences. The bacteria for transforming plants usually
contain binary vectors, such as a plasmid with a vir region of a Ti plasmid and
a plasmid with a T region containing a DNA sequence of interest. Published in
the United States as US 2005/0289672 and
US
2005/0289667, and as PCT Publication
WO
2006/004914, and as European Patent Application EP 1781082 and as
application number 200580029146.8 in China. More
information about TransBacter

and glucuronidase genes from other microbes which encode forms of
β-glucuronidase with different properties,

e.g.

secreted forms, are provided. These genes and the proteins they encode may
be used as effectors in transformation of plant cells, and for other uses in
plant biotechnology. Animal and health applications may also be made available.
Issued in the United States as Patent Numbers

Nucleic acid sequences, gene products, expression vectors and host cells
suitable for expressing β-glucuronidase are provided. In addition, uses of the
β-glucuronidase as a visual and as a selectable marker for transformation are
also described. Issued in the United States as US Patent 7,148,407. Also
published as