Peripheral Neuropathy Sjogrens Treatment

When you had originally presented to the office,you presented with chronic numbness, tingling, burning, in the hands and the feet. It limitedyour ability to walk, limited your ability to sleep, your ability to relax. We've completeda course of treatment here with the Davis neuropathy program, how have you done withthe treatment and how are you feeling today? I feel wonderful. I have to tell you thatthe treatment, I was on both programs. Before I came in, all that I knew that I had wasperipheral neuropathy after your exam, after you examined me. We found out that I had alsospinal stenosis in my spine. I have followed your program, both of your programs, the DRSprogram and the peripheral neuropathy program,

and I am doing beautifully. I can now walkwithout assistance which I was having to hold my husband's hand or somebody's hand whenI was shopping or doing anything. I could not drive by myself. I feel like a whole personnow. Well congratulations on your results and we're very proud to have you here as apatient. What else would you like to have me tell you? If you have another questionI could certainly, I would like to tell a little bit about your people that you haveworking for you. They are wonderful, young, professional people. I don't know what kindof a program you put them on, but I love each and every one of them. They're an asset toyour office. Well thank you so much for the

Feel This Pain S3E7 Sjgrens

Hello and welcome to anotheredition of Feel This Pain. I'm Ken McKim and tonightwe're going to be talking a little bit about somethingknown as SjÃ¶gren's disease. Now, if you were to do acursory Google search on SjÃ¶gren's, you might come away thinking, quot;Oh, it's no big deal. It's just dry mouth and dry eyes, right?quot; It's much more than that.

SjÃ¶gren's is an autoimmunedisease that causes your lymphocytes to attackyour exocrine glands, which are responsiblefor producing moisture in the eyes, mouth and other tissues. It is much more than justa syndrome that makes your mouth dry and your eyes gritty. Now, many patients experiencedry eyes and dry mouth, but also fatigue and joint pain,because of the inflammation

that SjÃ¶gren's can cause. A dry mouth is not a benign thing to have. Think about it. Without saliva you don'tdigest food as well, because saliva is the firststep in the digestion process. Also without saliva production,your teeth are almost guaranteed to decay, andyou are much more prone to oral infections.

What is SjÃ¶gren's? There are basicallytwo types of Sjogren's. Primary, where it occurson its own and Secondary, where it appears withanother autoimmune condition like rheumatoid arthritis or lupus. SjÃ¶gren's can affect thenervous system, resulting in Peripheral Neuropathy,which is damage to the nerves in the arms and the legs,which causes pain, numbness

and weakness or CranialNeuropathy, which is the same thing in your face, witha loss of taste and smell, on top of it. It can also affect thekidneys with Glomerulonephritis, which is the inflammationof the kidney's filter, resulting in Edema, bloodin urine, and reduction in the amount of urine produced. Sounds fun, right?

No. SjÃ¶gren's can also affectthe lungs, inflaming the air sacs causing them to thicken and scar, which can make breathing very difficult. Are there treatments? Well, of course there are. It's an incurablecondition, but you can treat the symptoms.

Undiagnosed Small Fiber Polyneuropathy Is It a Component of Gulf War Illness

GWIRP 2012 Investigator Vignette Title: Undiagnosed Small Fiber Polyneuropathy:Is It a Component of Gulf War Illness? Investigators: Max Klein, PhD and Anne LouiseOaklander, MD, PhD; Massachusetts General Oaklander: Our grant is to test the hypothesisthat what we call Gulf War Illness may in some patients be a signal of underlying peripheralneuropathy. Klein: And so we're recruiting 150 Veteranswho are ill with Gulf War Illness and also 150 Veterans who are free of Gulf War Illness.And we're comparing their results with these

test results that we've obtained in thepast to see which ones give us the best indication of Gulf War Illness and hence, small fiberpolyneuropathy. Oaklander: Gulf War Illness is a mysteriousconstellation of symptoms, socalled multiorgan symptoms, meaning they affect a lot of differentparts of the body. Other labs have established that Gulf War Illness is a true medical problem,but no one has been able to figure out what the underlying cause is. And that's reallyimportant because when you don't know the cause of something it's very hard to treatit effectively. Klein: What we're studying right now isthe hypothesis that there's a component

of Gulf War Illness that may be due to a specifictype of small fiber polyneuropathy; that would be a disorder of some small nerve fibers.And it turns out that the symptoms from this small fiber polyneuropathy bear a strong resemblanceto a lot of the symptoms of Gulf War Illness. And so what we're trying to do is to establisha relationship between the two with a series of tests. Oaklander: This research grant has two partsto it. The first is to study normal nonVeteran as well as Veterans to find out what are thebest tests to diagnose this kind of small fiber polyneuropathy.

The second part of the study is to apply thesebest tests specifically to Gulf War Ill Veterans and controls to see if we can detect smallfiber polyneuropathy disproportionately among the Gulf WarIll population. Specific testsinclude the use of skin biopsies that are specially stained to reveal the nerve endingswithin. These are counted and compared to what we would expect from a normal personto look for evidence of neuropathy. We also use a battery of tests of autonomic function,things such as heart rate, blood pressure, and sweating activity. These are all underneural control, and so if they're abnormal, it can be a sign of neuropathy.

Klein: So the first one is a sweat test andwe introduce a little chemical into the skin that will actually make you sweat in a certainarea, and we actually collect the sweat and measure it and see how much sweat has beenproduced in that area. And another test is a tilt table test. Andall we do there is we're simulating the action of say when you stand up suddenly froma crouched position. You sometimes get lightheaded because your body hasn't quite reacted torestored blood flow to your brain fast enough. So we do exactly that; and all the while we'remonitoring their heart rate and blood pressure. What we're really looking for mostly isa reaction to theâ€”the stress that we're

putting on the body. So the difference betweenbeing recumbent and being tilted upward should result in a characteristic change in yourblood pressure and heart rate, which if your body is functioning correctly will then recoverfrom. So we have of course the biopsy where we'relooking for abnormal densities of nerve fibers in the skin. So that tells us one thing. Theseautonomic function tests tell us if there's a malfunction in the nerve fibers.And it turnsout that results of the skin biopsy and results with the autonomic function test don't alwayscorrelate at the same time; so in other words, it may be that oneâ€”one effect is seen beforethe other. So we're trying to establish

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