About this book

This important reference provides up-to-date information on all aspects of ribosome-inactivating proteins (RIPs). Including a list of all known RIPs, their distribution in nature, structure, genetics and chemical and immunological properties, Ribosome-Inactivating Proteins covers mechanisms of action, including the enzymatic activity on various polynucleotide substrates; the interaction with, and entry into cells; the toxicity to animals, including the pathology of poisoning; and the immunomodulatory and allergenic activity. Ribosome-Inactivating Proteins further emphasizes the use of immunotoxins and other conjugates in clinical trials for the therapy of cancer and intractable pain.

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Biography

Fiorenzo Stirpe is Professor Emeritus at the Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Italy. Douglas A. Lappi is the President and Chief Scientific Officer of Advanced Targeting Systems, USA.