"It was an opportunity for them to continue the discussions they've been having and to speak in advance of Secretary Clinton's arrival in the region. President Obama underscored once again the importance of working for a de-escalation to the conflict in Gaza.

"He commended President Morsi's efforts to pursue a de-escalation. And he also underscored that President Morsi's efforts reinforce the important role that President Morsi and Egypt play on behalf of regional security and the pursuit of broader peace between the Palestinians and Israelis."

The call lasted nearly 30 minutes, and it was the third time in the last 24 hours that the U.S. and Egyptian leaders have spoken.

"It indicates that Egypt plays a very important role in this process," Rhodes said.

He added that any agreement must include an end to rocket fire into Israel: "Without an end to rocket fire into Israel from Gaza, Israel can't be assured of the security of its people."