It tells the story of a basketball player named Tetsuya Kuroko of the Seirin school basketball team and his struggles to defeat the “Five strongest players in the history of basketball”. The manga starts with introduction of a basketball team known as "the strongest", five players in history that made the basketball team of Teikou middle school to be known as the "Generation of Miracles". However, there is still a sixth player that is recognized as above those of the five strongest, Kuroko Tetsuya, "the sixth, ghost player".
After finishing middle school, players of the "Generation of Miracles decided to go to each different school and strive to be the number 1 with their respective teams.
Kuroko decides to enter a newly created institute, Seirin. An institute that last year with their team composed only of freshmen had managed to reach the Tokyo final league. And along with Kuroko, comes another rookie: Kagami Taiga, a player with unique physical and technical skills. Together they decided to take on the top Seirin Japanese basketball players and defeat all of the Generation of Miracles.