... Well it usually takes six to 8 weeks to feel some effects although it hasnt been helping me much. I have RA for many years and alreadly had a total knee replacement 12 years ago at age 36. ... (2 replies)

... Hi Mysteria....I spent about 7 years on Plaquenil and 5 years on MTX and just recently went off both as I see just how well another drug works. Plaquenil caused worse hair loss with me than the MTX...about half my hair fell out but I'll take bald over pain any day. But I had to stop as I developed eye problems. ... (4 replies)

... It's very hard to sit for too long, I can feel the pressure in my spine and rear end...and plus if I sit too long, I get sooo stiff, it's very hard to get up and try to straighten up. ... (17 replies)

... I have been taking injectable methotrexate after the oral doses lost thier effectiveness. It is a small price to pay for the relief I receive for my psoratic arthritits. There are side effects, but the most bothersome such as dizziness and nausia subsided within 6 weeks. ... (4 replies)