Tibana R.A.,Catholic University of Brasilia | Da Cunha Nascimento D.,Catholic University of Brasilia | De Sousa N.M.F.,Laboratory of Exercise Physiology | De Souza V.C.,Catholic University of Brasilia | And 9 more authors.PLoS ONE | Year: 2014

Fonseca T.R.,Federal University of Minas Gerais | Botelho F.V.,Federal University of Minas Gerais | Botelho F.V.,Federal University of Uberlandia | De Lima D.C.,Federal University of Minas Gerais | And 4 more authors.Journal of Exercise Physiology Online | Year: 2011

This study evaluated the effects of 6 weeks of swimming on lipid metabolism, oxidation resistance, and atherosclerosis in 6-week-old female apolipoprotein E-deficient mice (apoE -/-). The mice were divided into a control group (n=7) and a treatment group (n=7). Mice in the treatment group were required to swim 10 min·d -1, 5 d·wk -1 for 6 weeks (which was increased by 10 min·d -1 until the mice swam continuously for 1 hr). Plasma total cholesterol was evaluated before and after the experiment. Liver and fecal lipids, lipid oxidation resistance, and atherosclerotic area of thoracic and abdominal aorta were evaluated after euthanasia. Body weight, lipid metabolism, and lipid oxidation resistance were similar in both groups. Relative index was statistically decreased in the experimental group, thus suggesting that the apoE -/- mice that underwent the swimming exercise exhibited decreased atherosclerotic lesions in the aorta. However, the decrease was not due to changes in lipid metabolism or lipid oxidation resistance profile.
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