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Dependence  10,861 patients of the Innsbruck University Department of Psychiatry  WHO criteria were used for the diagnosis of dependence.  Only 9 inpatients and 21 outpatients were addicted to BZs.  Fleischhacker: Acta Psychiatrica Scand 2007;74:80

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Net Result on GABA A  General resistance to benzodiazepines caused by a change in receptor subunit conformation  Shift toward BZ2 receptor – tolerance to sedation with some maintenance of anticonvulsant effects