The proportion of subjects who meet the definition of "transfusion reduction" (TR).

The proportion of treated subjects who meet the definition of "transfusion independence" (TI). TI is defined as Hb ≥9g/dL without any RBC transfusions for a continuous period of ≥12 months at any time during the study after drug product infusion.

Percentage of subjects with a reduction in the mL/kg RBC transfused from Month 12 through Month 24 after drug product infusion of at least 50% compared to the average annual RBC transfusion requirement during the 2 years prior to enrollment.

Examine the level of chimerism required to maintain both graft survival as well as hematologic normalcy using a regimen containing pentostatin, cyclophosphamide, alemtuzumab, and low total body irradiation.

162

All

16 Years to 80 Years (Child, Adult, Senior)

NCT02105766

14007714-H-0077

April 1, 2014

August 31, 2021

August 31, 2021

April 7, 2014

February 9, 2018

National Institutes of Health Clinical Center, 9000 Rockville PikeBethesda, Maryland, United States