SummaryNeandertals and Denisovans, an Asian group distantly related to Neandertals, are the closest evolutionary relatives of present-day humans. They are thus of direct relevance for understanding the origin of modern humans and how modern humans differ from their closest relatives. We will generate genome-wide data from a large number of Neandertal and Denisovan individuals from across their geographical and temporal range as well as from other extinct hominin groups which we may discover. This will be possible by automating highly sensitive approaches to ancient DNA extraction and DNA libraries construction that we have developed so that they can be applied to many specimens from many sites in order to identify those that contain retrievable DNA. Whenever possible we will sequence whole genomes and in other cases use DNA capture methods to generate high-quality data from representative parts of the genome. This will allow us to study the population history of Neandertals and Denisovans, elucidate how many times and where these extinct hominins contributed genes to present-day people, and the extent to which modern humans and archaic groups contributed genetically to Neandertals and Denisovans. By retrieving DNA from specimens that go back to the Middle Pleistocene we will furthermore shed light on the early history and origins of Neandertals and Denisovans.

Neandertals and Denisovans, an Asian group distantly related to Neandertals, are the closest evolutionary relatives of present-day humans. They are thus of direct relevance for understanding the origin of modern humans and how modern humans differ from their closest relatives. We will generate genome-wide data from a large number of Neandertal and Denisovan individuals from across their geographical and temporal range as well as from other extinct hominin groups which we may discover. This will be possible by automating highly sensitive approaches to ancient DNA extraction and DNA libraries construction that we have developed so that they can be applied to many specimens from many sites in order to identify those that contain retrievable DNA. Whenever possible we will sequence whole genomes and in other cases use DNA capture methods to generate high-quality data from representative parts of the genome. This will allow us to study the population history of Neandertals and Denisovans, elucidate how many times and where these extinct hominins contributed genes to present-day people, and the extent to which modern humans and archaic groups contributed genetically to Neandertals and Denisovans. By retrieving DNA from specimens that go back to the Middle Pleistocene we will furthermore shed light on the early history and origins of Neandertals and Denisovans.

SummaryWe propose to develop truly two-dimensional continuous materials and two-dimensional monolayer films composed of individual nanocrystals by the comparatively fast, inexpensive, and scalable colloidal synthesis method. The materials’ properties will be studied in detail, especially regarding their (photo-) electrical transport. This will allow developing new types of device structures, such as Coulomb blockade and field enhancement based transistors.
Recently, we demonstrated the possibility to synthesize in a controlled manner truly two-dimensional colloidal nanostructures. We will investigate their formation mechanism, synthesize further materials as “nanosheets”, develop methodologies to tune their geometrical properties, and study their (photo-) electrical properties.
Furthermore, we will use the Langmuir-Blodgett method to deposit highly ordered monolayers of monodisperse nanoparticles. Such structures show interesting transport properties governed by Coulomb blockade effects known from individual nanoparticles. This leads to semiconductor-like behavior in metal nanoparticle films. The understanding of the electric transport in such “multi-tunnel devices” is still very limited. Thus, we will investigate this concept in detail and take it to its limits. Beside improvement of quality and exchange of material we will tune the nanoparticles’ size and shape in order to gain a deeper understanding of the electrical properties of supercrystallographic assemblies. Furthermore, we will develop device concepts for diode and transistor structures which take into account the novel properties of the low-dimensional assemblies.
Nanosheets and monolayers of nanoparticles truly follow the principle of building devices by the bottom-up approach and allow electric transport measurements in a 2D regime. Highly ordered nanomaterial systems possess easy and reliably to manipulate electronic properties what make them interesting for future (inexpensive) electronic devices.

We propose to develop truly two-dimensional continuous materials and two-dimensional monolayer films composed of individual nanocrystals by the comparatively fast, inexpensive, and scalable colloidal synthesis method. The materials’ properties will be studied in detail, especially regarding their (photo-) electrical transport. This will allow developing new types of device structures, such as Coulomb blockade and field enhancement based transistors.
Recently, we demonstrated the possibility to synthesize in a controlled manner truly two-dimensional colloidal nanostructures. We will investigate their formation mechanism, synthesize further materials as “nanosheets”, develop methodologies to tune their geometrical properties, and study their (photo-) electrical properties.
Furthermore, we will use the Langmuir-Blodgett method to deposit highly ordered monolayers of monodisperse nanoparticles. Such structures show interesting transport properties governed by Coulomb blockade effects known from individual nanoparticles. This leads to semiconductor-like behavior in metal nanoparticle films. The understanding of the electric transport in such “multi-tunnel devices” is still very limited. Thus, we will investigate this concept in detail and take it to its limits. Beside improvement of quality and exchange of material we will tune the nanoparticles’ size and shape in order to gain a deeper understanding of the electrical properties of supercrystallographic assemblies. Furthermore, we will develop device concepts for diode and transistor structures which take into account the novel properties of the low-dimensional assemblies.
Nanosheets and monolayers of nanoparticles truly follow the principle of building devices by the bottom-up approach and allow electric transport measurements in a 2D regime. Highly ordered nanomaterial systems possess easy and reliably to manipulate electronic properties what make them interesting for future (inexpensive) electronic devices.

Max ERC Funding

1 497 200 €

Duration

Start date: 2013-02-01, End date: 2019-01-31

Project acronymACROSSBORDERS

ProjectAcross ancient borders and cultures: An Egyptian microcosm in Sudan during the 2nd millennium BC

Researcher (PI)Julia Budka

Host Institution (HI)LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN

Call DetailsStarting Grant (StG), SH6, ERC-2012-StG_20111124

SummaryPharaonic Egypt is commonly known for its pyramids and tomb treasures. The present knowledge of Egyptian everyday life and social structures derives mostly from mortuary records associated with the upper classes, whereas traces of ordinary life from domestic sites are generally disregarded. Settlement archaeology in Egypt and Nubia (Ancient North Sudan) is still in its infancy; it is timely to strenghten this field. Responsible for the pottery at three major settlement sites (Abydos and Elephantine in Egypt; Sai Island in Sudan), the PI is in a unique position to co-ordinate a research project on settlement patterns in Northeast Africa of the 2nd millennium BC based on the detailed analysis of material remains. The selected case studies situated across ancient and modern borders and of diverse environmental and cultural preconditions, show very similar archaeological remains. Up to now, no attempt has been made to explain this situation in detail.
The focus of the project is the well-preserved, only partially explored site of Sai Island, seemingly an Egyptian microcosm in New Kingdom Upper Nubia. Little time is left to conduct the requisite large-scale archaeology as Sai is endangered by the planned high dam of Dal. With the application of microarchaeology we will introduce an approach that is new in Egyptian settlement archaeology. Our interdisciplinary research will result in novel insights into (a) multifaceted lives on Sai at a micro-spatial level and (b) domestic life in 2nd millennium BC Egypt and Nubia from a macroscopic view. The present understanding of the political situation in Upper Nubia during the New Kingdom as based on written records will be significantly enlarged by the envisaged approach. Furthermore, in reconstructing Sai Island as “home away from home”, the project presents a showcase study of what we can learn about acculturation and adaptation from ancient cultures, in this case from the coexistence of Egyptians and Nubians

Pharaonic Egypt is commonly known for its pyramids and tomb treasures. The present knowledge of Egyptian everyday life and social structures derives mostly from mortuary records associated with the upper classes, whereas traces of ordinary life from domestic sites are generally disregarded. Settlement archaeology in Egypt and Nubia (Ancient North Sudan) is still in its infancy; it is timely to strenghten this field. Responsible for the pottery at three major settlement sites (Abydos and Elephantine in Egypt; Sai Island in Sudan), the PI is in a unique position to co-ordinate a research project on settlement patterns in Northeast Africa of the 2nd millennium BC based on the detailed analysis of material remains. The selected case studies situated across ancient and modern borders and of diverse environmental and cultural preconditions, show very similar archaeological remains. Up to now, no attempt has been made to explain this situation in detail.
The focus of the project is the well-preserved, only partially explored site of Sai Island, seemingly an Egyptian microcosm in New Kingdom Upper Nubia. Little time is left to conduct the requisite large-scale archaeology as Sai is endangered by the planned high dam of Dal. With the application of microarchaeology we will introduce an approach that is new in Egyptian settlement archaeology. Our interdisciplinary research will result in novel insights into (a) multifaceted lives on Sai at a micro-spatial level and (b) domestic life in 2nd millennium BC Egypt and Nubia from a macroscopic view. The present understanding of the political situation in Upper Nubia during the New Kingdom as based on written records will be significantly enlarged by the envisaged approach. Furthermore, in reconstructing Sai Island as “home away from home”, the project presents a showcase study of what we can learn about acculturation and adaptation from ancient cultures, in this case from the coexistence of Egyptians and Nubians

Max ERC Funding

1 497 460 €

Duration

Start date: 2012-12-01, End date: 2018-04-30

Project acronymARCHCAUCASUS

ProjectTechnical and Social Innovations in the Caucasus: between the Eurasian Steppe and the Earliest Cities in the 4th and 3rd millennia BC

Researcher (PI)Svend HANSEN

Host Institution (HI)DEUTSCHES ARCHAOLOGISCHES INSTITUT

Call DetailsAdvanced Grant (AdG), SH6, ERC-2018-ADG

SummaryThis project leads to one of the most dynamic regions in prehistory: the Caucasus of the 4th and early 3rd mill. BC. During this vibrant time, basic innovations emerged, which were crucial until the 19th century: wheel and wagon, copper alloys, the potter’s wheel, new breeds of woolly sheep, domestication of the horse, and others. At the same time, massive migrations from the East European steppe during the early 3rd mill. BC changed the European gene pool.
The project challenges the still predominant narrative that all technical achievements stemmed from urban centres in Mesopotamia. New studies have created space for alternative hypotheses: possibly it was not the development of new techniques, but instead their adaptation from different ‘peripheries’ and their re-combination and re-configuration that formed the basis for the success of these ‘civilisations’.
The Caucasus, linking Mesopotamia to the Eurasia and Europe, is for the first time in the focus of a study on innovation transfer. The study will make a major contribution by investigation of four axial innovations: wheel and wagon, metal alloys, silver metallurgy and woolly sheep. 40 wheels will be analysed by computer tomography and strontium isotopes. Some 300 copper alloys artefacts and 200 silver objects will be examined using mass spectrometry with laser ablation. 400 aDNA genom-wide analyses of humans from burials in the North Caucasus will offer the unique chance of elucidating the role of migrations for the spread of innovations. The pottery in the region, often linked to Mesopotamia, will be studied under technical aspects and is a complementary path to shed light on migration and the transfer of knowledge. Excavations in settlements will allow building up a chronology using 400 AMS 14C analyses. The project is multidisciplinary, making use of the most up-to-date analytical methods. Our long experience and reputation on both sides of the Caucasus is the ideal background for cutting-edge research.

This project leads to one of the most dynamic regions in prehistory: the Caucasus of the 4th and early 3rd mill. BC. During this vibrant time, basic innovations emerged, which were crucial until the 19th century: wheel and wagon, copper alloys, the potter’s wheel, new breeds of woolly sheep, domestication of the horse, and others. At the same time, massive migrations from the East European steppe during the early 3rd mill. BC changed the European gene pool.
The project challenges the still predominant narrative that all technical achievements stemmed from urban centres in Mesopotamia. New studies have created space for alternative hypotheses: possibly it was not the development of new techniques, but instead their adaptation from different ‘peripheries’ and their re-combination and re-configuration that formed the basis for the success of these ‘civilisations’.
The Caucasus, linking Mesopotamia to the Eurasia and Europe, is for the first time in the focus of a study on innovation transfer. The study will make a major contribution by investigation of four axial innovations: wheel and wagon, metal alloys, silver metallurgy and woolly sheep. 40 wheels will be analysed by computer tomography and strontium isotopes. Some 300 copper alloys artefacts and 200 silver objects will be examined using mass spectrometry with laser ablation. 400 aDNA genom-wide analyses of humans from burials in the North Caucasus will offer the unique chance of elucidating the role of migrations for the spread of innovations. The pottery in the region, often linked to Mesopotamia, will be studied under technical aspects and is a complementary path to shed light on migration and the transfer of knowledge. Excavations in settlements will allow building up a chronology using 400 AMS 14C analyses. The project is multidisciplinary, making use of the most up-to-date analytical methods. Our long experience and reputation on both sides of the Caucasus is the ideal background for cutting-edge research.

Max ERC Funding

2 487 875 €

Duration

Start date: 2019-07-01, End date: 2024-06-30

Project acronymARMOR-T

ProjectArmoring multifunctional T cells for cancer therapy

Researcher (PI)Sebastian Kobold

Host Institution (HI)LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN

Call DetailsStarting Grant (StG), LS7, ERC-2017-STG

SummaryAdoptive T cell therapy (ACT) is a powerful approach to treat even advanced cancer diseases where poor prognosis calls for innovative treatments. However ACT is critically limited by insufficient T cell infiltration into the tumor, T cell activation at the tumor site and local T cell suppression. Few advances have been made in the field to tackle these limitations besides increasing T cell activation. My group has focussed on these unaddressed issues but came to realise that tackling these one by one will not be sufficient. I have developed a panel of unpublished chemokine receptors and innovative modular antibody-activated receptors which have the potential to overcome the limitations of ACT against solid tumors. This ground-breaking portfolio places my group in the unique position to address combination of synergistic receptors and enable cellular therapies in previously unsuccessful indications. My project will provide the rationale for provision of an effective cancer treatment. The goal is to develop the next generation of ACT through T cell engineering both by forced expression of migratory and activating receptors and simultaneous deletion of immune suppressive molecules by gene editing. ARMOR-T will provide the basis for further preclinical and clinical development of a pioneering cellular product devoid of the limitations of available products to date. I will prove 1) synergy between migratory and modular activating receptors, 2) feasibility to integrate gene editing into a T cell expansion protocol, 3) synergy between gene editing, migratory and modular receptors and 4) efficacy, safety and mode of action. The main work of the project will be carried out in models of pancreatic cancer. The ARMOR-T platform will subsequently be translated to other cancer entities where response to ACT is likely such as melanoma, breast or colon cancer, providing less toxic and more effective therapies to otherwise untreatable disease.

Adoptive T cell therapy (ACT) is a powerful approach to treat even advanced cancer diseases where poor prognosis calls for innovative treatments. However ACT is critically limited by insufficient T cell infiltration into the tumor, T cell activation at the tumor site and local T cell suppression. Few advances have been made in the field to tackle these limitations besides increasing T cell activation. My group has focussed on these unaddressed issues but came to realise that tackling these one by one will not be sufficient. I have developed a panel of unpublished chemokine receptors and innovative modular antibody-activated receptors which have the potential to overcome the limitations of ACT against solid tumors. This ground-breaking portfolio places my group in the unique position to address combination of synergistic receptors and enable cellular therapies in previously unsuccessful indications. My project will provide the rationale for provision of an effective cancer treatment. The goal is to develop the next generation of ACT through T cell engineering both by forced expression of migratory and activating receptors and simultaneous deletion of immune suppressive molecules by gene editing. ARMOR-T will provide the basis for further preclinical and clinical development of a pioneering cellular product devoid of the limitations of available products to date. I will prove 1) synergy between migratory and modular activating receptors, 2) feasibility to integrate gene editing into a T cell expansion protocol, 3) synergy between gene editing, migratory and modular receptors and 4) efficacy, safety and mode of action. The main work of the project will be carried out in models of pancreatic cancer. The ARMOR-T platform will subsequently be translated to other cancer entities where response to ACT is likely such as melanoma, breast or colon cancer, providing less toxic and more effective therapies to otherwise untreatable disease.

Max ERC Funding

1 636 710 €

Duration

Start date: 2018-03-01, End date: 2023-02-28

Project acronymASC3

ProjectAsymmetric Cluster Catalysis & Chemistry

Researcher (PI)Ulrich Kaspar Heiz

Host Institution (HI)TECHNISCHE UNIVERSITAET MUENCHEN

Call DetailsAdvanced Grant (AdG), PE4, ERC-2009-AdG

SummaryThe objective of the present scientific proposal is the implementation of a novel approach in selective and asymmetric heterogeneous catalysis. We aim to exploit the structure and chirality of small, supported metal and bimetal clusters for triggering selective and enantioselective reactions. Our Ansatz is beyond doubt of fundamental nature. Although chemistry and in particular catalysis evolved on a largely empirical basis in the past, we strongly believe the complexity of the challenges at hand to make this a less ideal approach. In consequence, developing selective and asymmetric cluster catalysis will be based on a detailed molecular understanding and will not only require intense methodological developments for the synthesis and characterization of asymmetric catalysts and the detection of chiral and isomeric product molecules but also make use of innovative basic science in the fields of surface chemistry, cluster science, spectroscopy and kinetics. As complex as the involved challenges are, we aim at mastering the following ground-breaking steps: (a) development of cutting-edge spectroscopic methodologies for the isomer and enantiomer sensitive in situ detection of product molecules. (b) preparation and characterization of isomer- and enantioselective heterogeneous catalysts based on chiral metal clusters or molecule-cluster-complexes. (c) investigations of the selectivity and enantioselectivity of cluster based heterogeneous catalysts and formulation of concepts for understanding the observed selective and asymmetric chemistry.
Besides the importance of the science carried out within this proposal, the proposed experimental methodology will also open up opportunities in other fields of chemistry like catalysis, analytical chemistry, spectroscopy, surface science, and nanomaterials.

The objective of the present scientific proposal is the implementation of a novel approach in selective and asymmetric heterogeneous catalysis. We aim to exploit the structure and chirality of small, supported metal and bimetal clusters for triggering selective and enantioselective reactions. Our Ansatz is beyond doubt of fundamental nature. Although chemistry and in particular catalysis evolved on a largely empirical basis in the past, we strongly believe the complexity of the challenges at hand to make this a less ideal approach. In consequence, developing selective and asymmetric cluster catalysis will be based on a detailed molecular understanding and will not only require intense methodological developments for the synthesis and characterization of asymmetric catalysts and the detection of chiral and isomeric product molecules but also make use of innovative basic science in the fields of surface chemistry, cluster science, spectroscopy and kinetics. As complex as the involved challenges are, we aim at mastering the following ground-breaking steps: (a) development of cutting-edge spectroscopic methodologies for the isomer and enantiomer sensitive in situ detection of product molecules. (b) preparation and characterization of isomer- and enantioselective heterogeneous catalysts based on chiral metal clusters or molecule-cluster-complexes. (c) investigations of the selectivity and enantioselectivity of cluster based heterogeneous catalysts and formulation of concepts for understanding the observed selective and asymmetric chemistry.
Besides the importance of the science carried out within this proposal, the proposed experimental methodology will also open up opportunities in other fields of chemistry like catalysis, analytical chemistry, spectroscopy, surface science, and nanomaterials.

Summary"The objective of this proposal is to tackle two of the greatest challenges in quantum chemistry: (i) extending the applicability of highly accurate wave function methods to large molecular systems, and (ii) developing accurate and robust multi-reference methods that can be used for studying important but very difficult problems in transition metal chemistry, catalysis, and photochemistry. Solutions to these problems have now come within reach due to three advances we recently reported: first, the steep scaling of the computational cost with molecular size can be reduced to linear by exploiting the short-range character of electron correlation (local correlation methods). Second, the accuracy, efficiency, and robustness of these local correlation methods can be strongly improved by new tensor decomposition approaches and the inclusion of terms depending explicitly on the inter-electronic distances (F12 methods). Third, the development of highly complex electronic structure theories can be greatly facilitated and accelerated by new automated tensor network evaluation techniques. We are certain that by combining and generalizing these advances the long-standing problems (i) and (ii) can be solved. We will focus especially on highly scalable algorithms in order to use massively parallel computer systems efficiently. For linear-scaling methods this means that the size of the molecules that can be treated in a fixed time will grow linearly with the number of available processors. We will furthermore explore new multi-reference ansätze and implement analytical energy gradients and response properties for local methods. Hybrid and embedding methods to account for solvent and environment effects will also be investigated. It is our priority to make our new methods as easy to use, robust, and widely applicable as possible. We believe that they will open entirely new horizons for innumerable applications in chemistry, physics, biology, and materials science."

"The objective of this proposal is to tackle two of the greatest challenges in quantum chemistry: (i) extending the applicability of highly accurate wave function methods to large molecular systems, and (ii) developing accurate and robust multi-reference methods that can be used for studying important but very difficult problems in transition metal chemistry, catalysis, and photochemistry. Solutions to these problems have now come within reach due to three advances we recently reported: first, the steep scaling of the computational cost with molecular size can be reduced to linear by exploiting the short-range character of electron correlation (local correlation methods). Second, the accuracy, efficiency, and robustness of these local correlation methods can be strongly improved by new tensor decomposition approaches and the inclusion of terms depending explicitly on the inter-electronic distances (F12 methods). Third, the development of highly complex electronic structure theories can be greatly facilitated and accelerated by new automated tensor network evaluation techniques. We are certain that by combining and generalizing these advances the long-standing problems (i) and (ii) can be solved. We will focus especially on highly scalable algorithms in order to use massively parallel computer systems efficiently. For linear-scaling methods this means that the size of the molecules that can be treated in a fixed time will grow linearly with the number of available processors. We will furthermore explore new multi-reference ansätze and implement analytical energy gradients and response properties for local methods. Hybrid and embedding methods to account for solvent and environment effects will also be investigated. It is our priority to make our new methods as easy to use, robust, and widely applicable as possible. We believe that they will open entirely new horizons for innumerable applications in chemistry, physics, biology, and materials science."

Max ERC Funding

2 454 000 €

Duration

Start date: 2013-02-01, End date: 2018-01-31

Project acronymASIAPAST

ProjectFrom herds to empire: Biomolecular and zooarchaeological investigations of mobile pastoralism in the ancient Eurasian steppe

Researcher (PI)Cheryl Ann Makarewicz

Host Institution (HI)CHRISTIAN-ALBRECHTS-UNIVERSITAET ZU KIEL

Call DetailsConsolidator Grant (CoG), SH6, ERC-2017-COG

SummaryThe emergence of mobile pastoralism in the Eurasian steppe five thousand years ago marked a unique transformation in human lifeways where, for the first time, people relied almost exclusively on herd animals of sheep, goat, cattle, and horses for sustenance and as symbols. Mobile pastoralism also generated altogether new forms of socio-political organization exceptional to the steppe that ultimately laid the foundation for nomadic states and empires. However, there remain striking gaps in our knowledge of how the pastoralist niche spread and evolved across Eurasia in the past and influenced cultural trajectories that frame the human-herd systems of today. Little is known about the scale of pastoralist movements connected with the initial translocation of domesticated animals, how mobility became embedded in pastoralist life, or how movement contributed to the formation of sophisticated political networks. There is a poor understanding of the character of herd animal husbandry strategies that were central to pastoralist subsistence and how these co-evolved alongside pastoralist dietary intake and ritual use of herd animals. We have a remarkably poor understanding of what pastoralists ate, especially the dietary contribution of dairy products - the quintessential dietary cornerstone food of pastoralist societies.
ASIAPAST addresses these gaps through a biomolecular approach that recovers the dietary and mobility histories of pastoralists and their animals recorded in bones, teeth, and pottery. This project pairs these methods to detailed analyses of the economic and symbolic use of herd animals preserved in zooarchaeological archives. These investigations draw from materials obtained from key sites that capture the transition to mobile pastoralism, its intensification, and emergence of trans-regional political structures located across the culturally connected regions of Mongolia, Kazakhstan, Russia, Kyrgyzstan, and Uzbekistan.

The emergence of mobile pastoralism in the Eurasian steppe five thousand years ago marked a unique transformation in human lifeways where, for the first time, people relied almost exclusively on herd animals of sheep, goat, cattle, and horses for sustenance and as symbols. Mobile pastoralism also generated altogether new forms of socio-political organization exceptional to the steppe that ultimately laid the foundation for nomadic states and empires. However, there remain striking gaps in our knowledge of how the pastoralist niche spread and evolved across Eurasia in the past and influenced cultural trajectories that frame the human-herd systems of today. Little is known about the scale of pastoralist movements connected with the initial translocation of domesticated animals, how mobility became embedded in pastoralist life, or how movement contributed to the formation of sophisticated political networks. There is a poor understanding of the character of herd animal husbandry strategies that were central to pastoralist subsistence and how these co-evolved alongside pastoralist dietary intake and ritual use of herd animals. We have a remarkably poor understanding of what pastoralists ate, especially the dietary contribution of dairy products - the quintessential dietary cornerstone food of pastoralist societies.
ASIAPAST addresses these gaps through a biomolecular approach that recovers the dietary and mobility histories of pastoralists and their animals recorded in bones, teeth, and pottery. This project pairs these methods to detailed analyses of the economic and symbolic use of herd animals preserved in zooarchaeological archives. These investigations draw from materials obtained from key sites that capture the transition to mobile pastoralism, its intensification, and emergence of trans-regional political structures located across the culturally connected regions of Mongolia, Kazakhstan, Russia, Kyrgyzstan, and Uzbekistan.

Max ERC Funding

1 999 145 €

Duration

Start date: 2018-04-01, End date: 2023-03-31

Project acronymASTROLAB

ProjectCold Collisions and the Pathways Toward Life in Interstellar Space

SummaryModern telescopes like Herschel and ALMA open up a new window into molecular astrophysics to investigate a surprisingly rich chemistry that operates even at low densities and low temperatures. Observations with these instruments have the potential of unraveling key questions of astrobiology, like the accumulation of water and pre-biotic organic molecules on (exo)planets from asteroids and comets. Hand-in-hand with the heightened observational activities comes a strong demand for a thorough understanding of the molecular formation mechanisms. The vast majority of interstellar molecules are formed in ion-neutral reactions that remain efficient even at low temperatures. Unfortunately, the unusual nature of these processes under terrestrial conditions makes their laboratory study extremely difficult.
To address these issues, I propose to build a versatile merged beams setup for laboratory studies of ion-neutral collisions at the Cryogenic Storage Ring (CSR), the most ambitious of the next-generation storage devices under development worldwide. With this experimental setup, I will make use of a low-temperature and low-density environment that is ideal to simulate the conditions prevailing in interstellar space. The cryogenic surrounding, in combination with laser-generated ground state atom beams, will allow me to perform precise energy-resolved rate coefficient measurements for reactions between cold molecular ions (like, e.g., H2+, H3+, HCO+, CH2+, CH3+, etc.) and neutral atoms (H, D, C or O) in order to shed light on long-standing problems of astrochemistry and the formation of organic molecules in space.
With the large variability of the collision energy (corresponding to 40-40000 K), I will be able to provide data that are crucial for the interpretation of molecular observations in a variety of objects, ranging from cold molecular clouds to warm layers in protoplanetary disks.

Modern telescopes like Herschel and ALMA open up a new window into molecular astrophysics to investigate a surprisingly rich chemistry that operates even at low densities and low temperatures. Observations with these instruments have the potential of unraveling key questions of astrobiology, like the accumulation of water and pre-biotic organic molecules on (exo)planets from asteroids and comets. Hand-in-hand with the heightened observational activities comes a strong demand for a thorough understanding of the molecular formation mechanisms. The vast majority of interstellar molecules are formed in ion-neutral reactions that remain efficient even at low temperatures. Unfortunately, the unusual nature of these processes under terrestrial conditions makes their laboratory study extremely difficult.
To address these issues, I propose to build a versatile merged beams setup for laboratory studies of ion-neutral collisions at the Cryogenic Storage Ring (CSR), the most ambitious of the next-generation storage devices under development worldwide. With this experimental setup, I will make use of a low-temperature and low-density environment that is ideal to simulate the conditions prevailing in interstellar space. The cryogenic surrounding, in combination with laser-generated ground state atom beams, will allow me to perform precise energy-resolved rate coefficient measurements for reactions between cold molecular ions (like, e.g., H2+, H3+, HCO+, CH2+, CH3+, etc.) and neutral atoms (H, D, C or O) in order to shed light on long-standing problems of astrochemistry and the formation of organic molecules in space.
With the large variability of the collision energy (corresponding to 40-40000 K), I will be able to provide data that are crucial for the interpretation of molecular observations in a variety of objects, ranging from cold molecular clouds to warm layers in protoplanetary disks.

SummaryThe goal of the research program, ASTROROT, is to significantly advance the knowledge of astrochemistry by exploring its molecular complexity and by discovering new molecule classes and key chemical processes in space. So far, mostly physical reasons were investigated for the observed variations in molecular abundances. We here propose to study the influence of chemistry on the molecular composition of the universe by combining unprecedentedly high-quality laboratory spectroscopy and pioneering telescope observations. Array telescopes provide new observations of rotational molecular emission, leading to an urgent need for microwave spectroscopic data of exotic molecules. We will use newly developed, unique broadband microwave spectrometers with the cold conditions of a molecular jet and the higher temperatures of a waveguide to mimic different interstellar conditions. Their key advantages are accurate transition intensities, tremendously reduced measurement times, and unique mixture compatibility.
Our laboratory experiments will motivate and guide astronomic observations, and enable their interpretation. The expected results are
• the exploration of molecular complexity by discovering new classes of molecules in space,
• the detection of isotopologues that provide information about the stage of chemical evolution,
• the generation of abundance maps of highly excited molecules to learn about their environment,
• the identification of key intermediates in astrochemical reactions.
The results will significantly foster and likely revolutionize our understanding of astrochemistry. The proposed research will go far beyond the state-of-the-art: We will use cutting-edge techniques both in the laboratory and at the telescope to greatly improve and speed the process of identifying molecular fingerprints. These techniques now enable studies at this important frontier of physics and chemistry that previously would have been prohibitively time-consuming or even impossible.

The goal of the research program, ASTROROT, is to significantly advance the knowledge of astrochemistry by exploring its molecular complexity and by discovering new molecule classes and key chemical processes in space. So far, mostly physical reasons were investigated for the observed variations in molecular abundances. We here propose to study the influence of chemistry on the molecular composition of the universe by combining unprecedentedly high-quality laboratory spectroscopy and pioneering telescope observations. Array telescopes provide new observations of rotational molecular emission, leading to an urgent need for microwave spectroscopic data of exotic molecules. We will use newly developed, unique broadband microwave spectrometers with the cold conditions of a molecular jet and the higher temperatures of a waveguide to mimic different interstellar conditions. Their key advantages are accurate transition intensities, tremendously reduced measurement times, and unique mixture compatibility.
Our laboratory experiments will motivate and guide astronomic observations, and enable their interpretation. The expected results are
• the exploration of molecular complexity by discovering new classes of molecules in space,
• the detection of isotopologues that provide information about the stage of chemical evolution,
• the generation of abundance maps of highly excited molecules to learn about their environment,
• the identification of key intermediates in astrochemical reactions.
The results will significantly foster and likely revolutionize our understanding of astrochemistry. The proposed research will go far beyond the state-of-the-art: We will use cutting-edge techniques both in the laboratory and at the telescope to greatly improve and speed the process of identifying molecular fingerprints. These techniques now enable studies at this important frontier of physics and chemistry that previously would have been prohibitively time-consuming or even impossible.