Thereafter additional increases may be necessary, but the total daily dose should usually not be exceeded a maximum of 80 mg, although in hospitalized patients, daily doses of 100 – 120 mg may occasionally be given.

Children : Treatment should be started at a very low dose e.g. 0.3 mg / kg per day in divided doses. The dosage should be raised cautiously at 1 – 2 week intervals until it is sufficient for the child’s individual needs. The usual dosage range for maintenance therapy is 0.75 to 2 mg / kg body weight per day. In children, aged over 10 years, a maximum daily dose of 2.5mg / kg bodyweight may be given.