On 8 June 1780, a small body of Whig militia led by Colonel William Bratton surprised a gathering point of Tory militia at Mobley's Meeting House, about 6 miles (9.7 km) west of present-day Winnsboro. Many of the Tories tried to escape by descending a steep embankment; this attempt led to more casualties than were caused by the actual firefight. A few Tories holed up in a blockhouse but were flushed out and defeated.

Tories in the area began raiding and plundering Whig properties, and in early June 1780 established a camp at Mobley's Meeting House, about 12 miles (19 km) north of Shirer's Ferry, located on a high embankment on a branch of the Little River in Fairfield District. They were under the general command of Colonel Robert Coleman of Fairfield District, Colonel Joseph Fleuquinyan and Captain William Nichols. This group had plundered many of the possessions of Whigs in the area, in particular members of the Hampton family, and had sent John and Henry Hampton as prisoners to Lord Cornwallis at Camden. Thus laden down with booty, they awaited British assistance.

Richard Winn, a prominent Whig leader in the area, began to rally supporter to his side. By June 7 he had rallied a force of between one and two hundred men in the New Acquisition District (roughly York County, South Carolina). Its principal commanders were Colonel William Bratton, who had been leading Whig militia since the war began in 1775, as well as Colonels Edward Lacey, John McClure, Samuel Watson, Cooper, and William Hill. This group was composed in large part of the Whig forces that had just the day before routed and scattered a Tory gathering at Beckhamville, South Carolina. Colonel Bratton was elected overall field commander for the engagement, which rode for Mobley's that day, arriving in the early morning hours. They found that the camp, although it had a fortified blockhouse and the meetinghouse itself was of sturdy construction, was not particularly alert against possible attack, and planned a surprise attack.

The attack occurred at daybreak with an assault on the church and blockhouse. The Whig forces attacked from three sides, leaving the fourth uncovered as it was thought that its steep embankment was too hazardous to climb for an attack or to descend in a retreat. However, during the confusion and panic, a number of Tories attempted just that and were injured in the process. Few casualties were noted on either side other than those resulting from falls down the embankment. Much of the plunder was recovered and restored to the owners, and a significant number of prisoners were taken and sent to North Carolina. According to Whig reports, they suffered no casualties in the brief battles, while the Tories suffered a few each killed and captured.

After the battle, some of the Whigs immediately left for North Carolina while others stayed in South Carolina and returned to their homes. Colonel Turnbull, the British commander at Rocky Mount, sent the New York Volunteers (the Green Coat Tories) under Captain Christian Huck in reprisal. Huck's force went on a minor rampage, destroying Richard Winn's plantation, the home and parsonage of the Reverend John Simpson, and attacking a small company of Whigs that had been left to defend the ironworks of Colonel William Hill. After the destruction of the ironworks, Whigs continued to muster, leading to the rise of Thomas Sumter as a significant militia leader, and took their vengeance on Huck in July. A similar gathering of Tories in nearby North Carolina was scattered in the June 20 Battle of Ramsour's Mill.

Although minor in scope, this engagement and others like it represented important symbolic victories for the Whigs. Mobley's Meeting House and the Battle of Beckhamville were the first two Whig successes against a string of defeats at Charleston, Monck's Corner, Lenud's Ferry, and Waxhaws. Other setbacks at Brandon's Defeat and Hill's ironworks after the Beckhamville and Mobley's Meeting House successes continued to press the Whigs, but rallies at Huck's Defeat (Williamson's Plantation) and Ramsour's Mill provided strategically small victories that provided the moral and spiritual support to keep the Whigs going through these dark days. British victories were to continue at Camden and Fishing Creek only two months later, on 16 and 18 August 1780. Only on 7 October 1780 did a decisive Whig victory at Kings Mountain begin to turn the tide.

The location of the meeting house is about 6 miles (9.7 km) west of present-day Winnsboro on the waters of the Little River. A marker has been placed nearby, on SSR 18 at a point approximately 1.5 miles (2 km) west of the site. At one time, there was a road or pathway that went past the meeting house, but it is inaccessible today.

Scoggins, Michael C (2005). The Day It Rained Militia: Huck's Defeat and the Revolution in the South Carolina Backcountry, May–July 1780. Charleston, SC: The History Press. ISBN978-1-59629-015-0. OCLC60189717.