High-affinity cysteine-specific transporter with similarity to the Dal5p family of transporters, in S. cerevisiae the green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum and YCT1 is not an essential gene

Allantoinase, converts allantoin to allantoate in the first step of allantoin degradation, expression in S. cerevisiae sensitive to nitrogen catabolite repression

DAL1

YIR027C

PAS_chr1-3_0023

F2QLB0_KOMPC

1986

661

1986

0

Allantoinase

gene

PP7435_Chr1-0018

UGA2

Succinate semialdehyde dehydrogenase involved in the utilization of gamma-aminobutyrate (GABA) as a nitrogen source, part of the 4-aminobutyrate and glutamate degradation pathways, localized in S. cerevisiae to the cytoplasm

UGA2

YBR006W

PAS_chr1-3_0024

F2QLB1_KOMPC

1488

495

1488

0

Succinate-semialdehyde dehydrogenase

gene

PP7435_Chr1-0019

RAD57

Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA, involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis, forms heterodimer with Rad55p

RAD57

YDR004W

PAS_chr1-3_0025

A0A1G4KNY4_KOMPC

1545

514

1545

0

DNA repair protein

gene

PP7435_Chr1-0020

MAF1

Highly conserved negative regulator of RNA polymerase III, binds to the N-terminal domain of the Rpc160p subunit of Pol III to prevent closed-complex formation, localization and activity in S. cerevisiae are regulated by phosphorylation, mediated by TORC1, protein kinase A, and Sch9p, localizes to cytoplasm during vegetative growth and translocates to the nucleus and nucleolus under stress conditions

MAF1

YDR005C

PAS_chr1-3_0026

F2QLB3_KOMPC

990

329

990

0

RNA polymerase III regulator

gene

PP7435_Chr1-0021

PHM7

Protein of unknown function, expression is regulated by phosphate levels, in S. cerevisiae the green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole and protein abundance increases in response to DNA replication stress

PHM7

YOL084W

PAS_chr1-3_0027

F2QLB4_KOMPC

2697

898

2697

0

Uncharacterized phosphate metabolism protein

gene

PP7435_Chr1-0022

IPP1

Cytoplasmic inorganic pyrophosphatase (PPase), homodimer that catalyzes the rapid exchange of oxygens from Pi with water, highly expressed and essential in S. cerevisiae for viability, active-site residues show identity to those from E. coli Ppase

IPP1

YBR011C

PAS_chr1-3_0028

F2QLB5_KOMPC

861

286

861

0

Inorganic pyrophosphatase

gene

PP7435_Chr1-0023

TRP1

Phosphoribosylanthranilate isomerase that catalyzes the third step in tryptophan biosynthesis, in 2004, the sequence of TRP1 from strain S228C was updated by changing the previously annotated internal STOP (TAA) to serine (TCA)

TRP1

YDR007W

PAS_chr1-3_0029

F2QLB6_KOMPC

714

237

714

0

Phosphoribosylanthranilate isomerase

gene

PP7435_Chr1-0024

RFC4

Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon, in S. cerevisiae relocalizes to the cytosol in response to hypoxia

RFC4

YOL094C

PAS_chr1-3_0030

F2QLB7_KOMPC

975

324

975

0

Replication factor C (RF-C) subunit

gene

PP7435_Chr1-0025

VPS52

Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi, involved in localization of actin and chitin

VPS52

YDR484W

PAS_chr1-3_0031

F2QLB8_KOMPC

1758

585

1758

0

Golgi-associated retrograde protein (GARP) complex component

gene

PP7435_Chr1-0026

TAX4

EH domain-containing protein, involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy, Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p, Irs4p and Tax4p are involved in localizing Atg17p to the PAS, Pichia pastoris does not have the paralog IRS4

TAX4

YJL083W

PAS_chr1-3_0032

F2QLB9_KOMPC

1722

573

1722

0

Phosphatidylinositol 4,5-bisphosphate levels regulator protein

gene

PP7435_Chr1-0027

HMT1

Nuclear SAM-dependent mono- and asymmetric arginine dimethylating methyltransferase that modifies hnRNPs, including Npl3p and Hrp1p, affecting their activity and nuclear export, methylates U1 snRNP protein Snp1p and ribosomal protein Rps2p, interacts genetically with genes encoding components of Rpd3(L) and this interaction is important for Rpd3 recruitment to the subtelomeric region

Putative zinc cluster protein of unknown function, proposed to be involved in the regulation of energy metabolism, based on patterns of expression in S. cerevisiae and sequence analysis

GSM1

YJL103C

PAS_chr1-3_0036

F2QLR3_KOMPC

1596

531

1596

0

Putative zinc cluster protein

gene

PP7435_Chr1-0031

SET3

Defining member of the SET3 histone deacetylase complex which is a meiosis-specific repressor of sporulation genes, necessary for efficient transcription by RNAPII, one of two yeast proteins that contains both SET and PHD domains, Pichia pastoris does not have the paralog SET4

SET3

YKR029C

PAS_chr1-3_0037

F2QLR4_KOMPC

2829

942

2829

0

SET domain-containing protein

gene

PP7435_Chr1-0032

PAM16

Subunit of the import motor (PAM complex), the PAM complex is a component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex), forms a 1:1 subcomplex with Pam18p and inhibits its cochaperone activity, contains a J-like domain

Protein with similarity to YFR016C (Putative protein of unknown function, in S. cerevisiae the green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and bud, interacts with Spa2p and YFL016C is not an essential gene)