Week 4: Packers (3-0) at 49ers (1-2)

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Things aren't getting any easier for the struggling San Francisco 49ers, who were outscored 90-25 in their last two games. They're set to take on Aaron Rodgers and the undefeated Packers on Sunday as they look to avoid a 1-3 start.

Through three weeks, Rodgers is completing passes at the highest rate of his career and hoping to beat San Francisco for the first time since 2010. That four-game stretch includes consecutive playoff losses to Colin Kaepernick under former 49ers head coach Jim Harbaugh.

But with Harbaugh gone, along with former defensive coordinator Vic Fangio, the 49ers are relying on new defensive coordinator Eric Mangini to create a scheme to stop the reigning league MVP. His defense allowed 676 yards passing over the last two weeks.

Rodgers is coming off a five-touchdown, 333-yard performance in a 38-28 win over the Kansas City Chiefs on Monday night. His 10 touchdown passes lead the NFL.

The last time the 49ers faced Rodgers came in frigid Green Bay, when they held him to 177 yards passing and just one touchdown in the wild card round of the playoffs in January 2014. San Francisco won that game 23-20 on a 33-yard field goal from Phil Dawson as time expired.

Rodgers, 31, might be playing at the highest level of his 11-year career. He's been without two of his three best receiving threats for chunks of the season, including star receiver Jordy Nelson, who tore his anterior cruciate ligament in his right knee in a preseason game against the Steelers. One of Nelson's understudies, Davante Adams, has been in and out of the lineup with a left ankle injury.