I noticed almost immediate changes in my hair, within a week of starting the medication. It became dry and limp. It's better now that I am using a moisturizing shampoo and deep conditioner as well as jojoba oil. I have noticed some increased shedding occasionally but no visible hair loss. To be fair, I have also experienced increased shedding with other drugs, even greater than what has developed so far with Accutane. I am also in my third month. I think extreme hair loss/balding may be rare with Accutane but it seems like increased shedding, hair damage is not that unusual. I am taking biotin also to help prevent damage, I've read that can help but I'm not really sure about the true efficacy.