Bignell

Colin Richard Bignell, Cambridge GB

Patent application number

Description

Published

20120135029

METHOD FOR THE PURIFICATION OF PROTEIN COMPLEXES - The present invention provides an improved method for the purification of a mixture of complexes comprising a stress protein complexed to a peptide or peptide fragment from a source mixture, typically a cell lysate. The method of the invention provides for protein complexes to be purified using ion exchange chromatography based methods, wherein a modified buffer solution is used which results in the purified stress protein complexes being more immunogenic than protein complexes obtained using conventional methodology. The purified complexes can be used to produce improved vaccine preparations which elicit enhanced immune responses in the subjects to whom the vaccine compositions are administered.

05-31-2012

David Bignell, London GB

Patent application number

Description

Published

20110120288

SYSTEMS AND METHODS FOR AUTOMATIC COLLISION AVOIDANCE, GROUPING AND ALIGNMENT OF MUSICAL SYMBOLS - Systems and methods for editing a computer-base musical score include detecting a collision between objects placed in the score and automatically moving one of the colliding objects out of the way to eliminate the collision. Selection of the object to be moved is based on a comparison of the priority levels of the colliding objects. To enhance clarity and legibility of the score, objects are organized into groups of similar type objects. Groups are treated as a single object for the purposes of avoiding collisions. Certain object types are transformed, including scaled, rotated, or sheared, to avoid collisions.

05-26-2011

Helen Bignell, Waldon GB

Helen Bignell, Nr. Saffron Walden GB

Patent application number

Description

Published

20090093378

Method for sequencing a polynucleotide template - The invention relates to methods for pairwise sequencing of a double-stranded polynucleotide template, which methods result in the sequential determination of nucleotide sequences in two distinct and separate regions of the polynucleotide template.

04-09-2009

20140329698

METHODS FOR INDEXING SAMPLES AND SEQUENCING MULTIPLE POLYNUCLEOTIDE TEMPLATES - The invention relates to methods for indexing samples during the sequencing of polynucleotide templates, resulting in the attachment of tags specific to the source of each nucleic acid sample such that after a sequencing run, both the source and sequence of each polynucleotide can be determined. Thus, the present invention pertains to analysis of complex genomes (e.g., human genomes), as well as multiplexing less complex genomes, such as those of bacteria, viruses, mitochondria, and the like.

11-06-2014

Helen Bignell, Essex GB

Patent application number

Description

Published

20120015823

Methods for indexing samples and sequencing multiple polynucleotide templates - The invention relates to methods for indexing samples during the sequencing of polynucleotide templates, resulting in the attachment of tags specific to the source of each nucleic acid sample such that after a sequencing run, both the source and sequence of each polynucleotide can be determined. Thus, the present invention pertains to analysis of complex genomes (e.g., human genomes), as well as multiplexing less complex genomes, such as those of bacteria, viruses, mitochondria, and the like.

01-19-2012

20120316072

Methods for indexing samples and sequencing multiple polynucleotide templates - The invention relates to methods for indexing samples during the sequencing of polynucleotide templates, resulting in the attachment of tags specific to the source of each nucleic acid sample such that after a sequencing run, both the source and sequence of each polynucleotide can be determined. Thus, the present invention pertains to analysis of complex genomes (e.g., human genomes), as well as multiplexing less complex genomes, such as those of bacteria, viruses, mitochondria, and the like.

12-13-2012

Helen Rachel Bignell, Cambridge GB

Patent application number

Description

Published

20150197789

END MODIFICATION TO PREVENT OVER-REPRESENTATION OF FRAGMENTS - The invention relates to a method of preparing a 5′ and 3′ modified library of template polynucleotides and also the use of the 5′ and 3′ modified library of templates in methods of solid-phase nucleic acid amplification. In particular, the invention relates to a method of preparing a 5′ and 3′ modified library of template polynucleotides which have common sequences at their 5′ ends and at their 3′ ends, wherein over-representation of “end” sequences of the primary polynucleotide molecules from whence the 5′ and 3′ modified library is generated is greatly reduced or prevented.

07-16-2015

Helen Rachel Bignell, Essex GB

Patent application number

Description

Published

20090176662

End Modification to Prevent Over-Representation of Fragments - The invention relates to a method of preparing a 5′ and 3′ modified library of template polynucleotides and also the use of the 5′ and 3′ modified library of templates in methods of solid-phase nucleic acid amplification. In particular, the invention relates to a method of preparing a 5′ and 3′ modified library of template polynucleotides which have common sequences at their 5′ ends and at their 3′ ends, wherein over-representation of “end” sequences of the primary polynucleotide molecules from whence the 5′ and 3′ modified library is generated is greatly reduced or prevented.

07-09-2009

20100167954

METHOD OF LIBRARY PREPARATION AVOIDING THE FORMATION OF ADAPTOR DIMERS - The invention relates to a method of preparing a library of template polynucleotides which reduces and/or prevents the formation of adaptor-dimers. The invention also relates to the use of a library of templates prepared using the method of the invention for solid-phase nucleic acid amplification. In particular, the invention relates to a method of preparing a library of template polynucleotides which have common sequences at their 5′ ends and at their 3′ ends which is substantially free of adaptor-dimers.

Mark Bignell, Loughborough GB

Robert Alan Bignell, San Jose, CA US

Patent application number

Description

Published

20130198549

AUTONOMOUS POWER-GATING DURING IDLE IN A MULTI-CORE SYSTEM - To preserve power and increase the overall efficiency of the CPU, the platform idle driver causes the power gate controller to cut power to the idle core. Such power gating is autonomous, i.e., the operating system and the other cores are not involved. In operation, the platform idle driver first prepares the core and the power gate controller for power gating the core. The platform idle driver then triggers the power gating. The power gate controller monitors interrupts released by the interrupt controller, and if any on the released interrupts are associated with the power gated core, the power gate controller resumes dispersing power to the core.