Medical Xpress news tagged with:drug compoundshttp://medicalxpress.com/
en-usMedical Xpress internet news portal provides the latest news on science including: Physics, Nanotechnology, Life Sciences, Space Science, Earth Science, Environment, Health and Medicine.Cruise ships, schools may become safer from viruses because of new patentOutbreaks of stomach flu or noroviral gastroenteritis can easily occur in crowded quarters like cruise ships, army barracks and schools, but a recent patent may lead to antiviral drugs to help travelers, students, military personnel and others avoid infections.http://medicalxpress.com/news/2016-09-cruise-ships-schools-safer-viruses.html
Diseases, Conditions, SyndromesMon, 12 Sep 2016 13:02:42 ESTnews392904149Team makes Zika drug breakthroughA team of researchers from Florida State University, Johns Hopkins University and the National Institutes of Health has found existing drug compounds that can both stop Zika from replicating in the body and from damaging the crucial fetal brain cells that lead to birth defects in newborns.http://medicalxpress.com/news/2016-08-team-zika-drug-breakthrough.html
Diseases, Conditions, SyndromesMon, 29 Aug 2016 11:00:08 ESTnews391684940Open-source drug discovery a successIn what is being called the first-ever test of open-source drug-discovery, researchers from around the world have successfully identified compounds to pursue in treating and preventing parasite-borne illnesses such as malaria as well as cancer.http://medicalxpress.com/news/2016-07-open-source-drug-discovery-success.html
Medical researchThu, 28 Jul 2016 14:00:03 ESTnews388917497Discovery of new IRAP inhibitors to improve cognitive functionsNew Rochelle, June 1, 2016-Researchers have discovered three new inhibitors of insulin-regulated aminopeptidase (IRAP), compounds shown to improve cognitive functions in animal models of human disorders. The new inhibitors are able to block human IRAP at low concentrations with rapid reversibility, as described in a study published in ASSAY and Drug Development Technologies. The article is available free on the ASSAY and Drug Development Technologies website until July 1, 2016.http://medicalxpress.com/news/2016-06-discovery-irap-inhibitors-cognitive-functions.html
Medical researchWed, 01 Jun 2016 11:23:47 ESTnews383999017Breast cancer drug discovery offers hope of new treatmentsA drug for breast cancer that is more effective than existing medicines may be a step closer thanks to new research.http://medicalxpress.com/news/2016-05-breast-cancer-drug-discovery-treatments.html
CancerMon, 23 May 2016 11:32:13 ESTnews383221922New compounds have potential to combat Lyme diseaseWhen physicians diagnose Lyme disease, they usually prescribe standard antibiotics—and for many patients, that's enough. But for 10 to 20 percent of patients, the disease persists, causing joint paint, neurological difficulties and fatigue, among other symptoms.http://medicalxpress.com/news/2016-04-compounds-potential-combat-lyme-disease.html
Diseases, Conditions, SyndromesMon, 11 Apr 2016 06:27:57 ESTnews379574869Neuronal structures associated with memory sprout in response to novel moleculesChemists at the University of California San Diego have designed a set of molecules that promote microscopic, anatomical changes in neurons associated with the formation and retention of memories. These drug candidates also prevent deterioration of the same neuronal structures in the presence of amyloid-beta, a protein fragment that accumulates in the brains of people with Alzheimer's disease.http://medicalxpress.com/news/2016-04-neuronal-memory-response-molecules.html
NeuroscienceMon, 11 Apr 2016 02:57:15 ESTnews379562110Illuminating the broad spectrum of diseaseIn a paper published in Nature Biotechnology, researchers from the Broad Institute of MIT and Harvard and the Dana-Farber Cancer Institute describe a new method that dramatically simplifies an arduous experimental process in early drug discovery. Their method, called PRISM, uses a molecular barcoding system to test potential drug compounds on cancer and other cell lines at an unprecedented scale and speed. The system allows for pooling and testing of multiple cell lines simultaneously, and promises to accelerate the search for targeted therapies by better representing the broad genetic diversity of disease.http://medicalxpress.com/news/2016-02-illuminating-broad-spectrum-disease.html
CancerMon, 29 Feb 2016 11:00:08 ESTnews375965898Researchers develop novel cell line for screening of brain drugsResearchers from the Department of Pharmacy at the University of Copenhagen have developed a cell line, which may be used to investigate new drugs and help predict whether they are able to enter the brain.http://medicalxpress.com/news/2016-01-cell-line-screening-brain-drugs.html
Medical researchThu, 14 Jan 2016 03:35:51 ESTnews371964938Meningitis model shows infection's sci-fi-worthy creep into the brainScientists at Duke Medicine are using transparent fish to watch in real time as Cryptococcal meningitis takes over the brain. The resulting images are worthy of a sci-fi movie teaser, but could be valuable in disrupting the real, crippling brain infection that kills more than 600,000 people worldwide each year.http://medicalxpress.com/news/2015-09-meningitis-infection-sci-fi-worthy-brain.html
Medical researchTue, 29 Sep 2015 00:00:01 ESTnews362678489New drug-like compounds may improve odds of men battling prostate cancerResearchers at Southern Methodist University, Dallas, have discovered three new drug-like compounds that could ultimately offer better odds of survival to prostate cancer patients.http://medicalxpress.com/news/2015-09-drug-like-compounds-odds-men-prostate.html
CancerTue, 08 Sep 2015 13:52:06 ESTnews360939116Promising target for new drugs found in pancreatic cancer cellsPancreatic cancer is extremely deadly and often has a poor prognosis. Ranked as the fourth deadliest cancer in the U.S. and poised to move up within the next few years, pancreatic cancer is very difficult to detect in its early stages. Seldom diagnosed early and typically spreading rapidly, the disease has no effective treatment once it advances.http://medicalxpress.com/news/2015-08-drugs-pancreatic-cancer-cells.html
CancerTue, 25 Aug 2015 13:24:42 ESTnews359727867New compounds could reduce alcoholics' impulse to drinkAlcoholism inflicts a heavy physical, emotional and financial toll on individuals and society. Now new discoveries and promising animal studies are offering a glimmer of hope that a new class of drugs could treat the disease without many of the unwanted side effects caused by current therapies.http://medicalxpress.com/news/2015-08-compounds-alcoholics-impulse.html
AddictionWed, 19 Aug 2015 05:00:05 ESTnews359132943Team publishes findings about compound with potential for treating rheumatoid arthritisMontana State University researchers and their collaborators have published their findings about a chemical compound that shows potential for treating rheumatoid arthritis.http://medicalxpress.com/news/2015-05-team-publishes-compound-potential-rheumatoid.html
Arthritis & RheumatismThu, 21 May 2015 12:35:18 ESTnews351430500Experimental Ebola treatment boosts survival in miceThe number of new Ebola cases is tapering off, but the search for new treatments continues. Now, one research team has found potential drug candidates that successfully treated up to 90 percent of mice exposed to the Ebola virus. They report their findings in the journal ACS Infectious Diseases.http://medicalxpress.com/news/2015-05-experimental-ebola-treatment-boosts-survival.html
Diseases, Conditions, SyndromesWed, 20 May 2015 10:37:02 ESTnews351337016Researchers hope to forecast novel psychoactive substance use by the publicThe use of novel psychoactive substances – synthetic compounds with stimulant or hallucinogenic effects – is on the rise. The diversity and breadth of these substances has led policymakers, law enforcement officers, and healthcare providers alike to feel overwhelmed and underprepared for dealing with novel drugs. A recent article published in The American Journal of Drug and Alcohol Abuse proposes a "forecasting method" for policymakers and researchers to focus on what is likely to happen with new recreational drugs.http://medicalxpress.com/news/2015-05-psychoactive-substance.html
AddictionThu, 14 May 2015 06:11:30 ESTnews350802683Turning to freshwater sources to fight drug-resistant tuberculosis, other infectionsThe discovery of antibiotics produced by soil fungi and bacteria gave the world life-saving medicine. But new antimicrobials from this resource have become scarce as the threat of drug resistance grows. Now, scientists have started mining lakes and rivers for potential pathogen-fighters, and they've found one from Lake Michigan that is effective against drug-resistant tuberculosis. Their report on the new compound appears in the journal ACS Infectious Diseases.http://medicalxpress.com/news/2015-04-freshwater-sources-drug-resistant-tuberculosis-infections.html
Diseases, Conditions, SyndromesWed, 08 Apr 2015 12:32:46 ESTnews347715155Researchers make breakthrough on new anestheticsFor the first time since the 1970s, researchers are on the verge of developing a new class of anesthetics. According to a study published in the February issue of Anesthesiology, the official medical journal of the American Society of Anesthesiologists (ASA), a new approach to identifying compounds may lead to the next generation of anesthetics.http://medicalxpress.com/news/2015-01-breakthrough-anesthetics.html
MedicationsTue, 20 Jan 2015 08:00:03 ESTnews340956425Supercomputers link proteins to drug side effectsNew medications created by pharmaceutical companies have helped millions of Americans alleviate pain and suffering from their medical conditions. However, the drug creation process often misses many side effects that kill at least 100,000 patients a year, according to the journal Nature.http://medicalxpress.com/news/2014-10-supercomputers-link-proteins-drug-side.html
MedicationsMon, 20 Oct 2014 17:05:46 ESTnews333043537Potential clue to Ebola treatments uncovered, researchers say(HealthDay)—Scientists who mapped out the shape and structure of a key protein in the Ebola virus say their discovery could help efforts to develop drugs to prevent or treat infection with the deadly pathogen.http://medicalxpress.com/news/2014-10-potential-clue-ebola-treatments-uncovered.html
Diseases, Conditions, SyndromesThu, 09 Oct 2014 18:36:08 ESTnews332098558Possible breakthrough in battle against drug-resistant diseasesIn the war against drug-resistant diseases and so-called "superbugs", the family of bacteria known as CREs are a particularly nasty bunch.http://medicalxpress.com/news/2014-07-breakthrough-drug-resistant-diseases.html
Diseases, Conditions, SyndromesThu, 24 Jul 2014 07:20:09 ESTnews325405182Researchers discover a new anticancer compound using accelerated drug screening processA team of research scientists from VTT Technical Research Centre of Finland, the University of Turku and the University of Eastern Finland has discovered a previously unknown Cent-1 molecule that kills cancer cells. Their research also shows that new cancer drug candidates can be identified faster and at lower cost by using computer-assisted and cell-based screening of compounds.http://medicalxpress.com/news/2014-05-anticancer-compound-drug-screening.html
CancerWed, 21 May 2014 08:16:24 ESTnews319878971Potential new anti-malarial drug identifiedA significant milestone in the development of a potential new antimalarial medicine has been reached by scientists at the University of Dundee, in partnership with the Medicines for Malaria Venture (MMV).http://medicalxpress.com/news/2014-02-potential-anti-malarial-drug.html
Diseases, Conditions, SyndromesThu, 06 Feb 2014 08:58:32 ESTnews310899503International deal to screen potential cancer drugs using DNA 'barcodes'An innovative screening technology that tags compounds with unique strands of DNA – like barcodes – will be used to assess up to a billion prototype drug molecules for anti-cancer activity, under a collaboration announced today between The Institute of Cancer Research, London, Cancer Research Technology (CRT) and Denmark-based drug discovery company Nuevolution A/S.http://medicalxpress.com/news/2014-01-international-screen-potential-cancer-drugs.html
CancerWed, 22 Jan 2014 04:05:35 ESTnews309585888Drug testing without syringesMicroneedles on a sticking-plaster-like patch may be the painless and safe way doctors will test for drugs and some infections in the future, thanks to work supported by the Engineering and Physical Sciences Research Council (EPSRC).http://medicalxpress.com/news/2013-12-drug-syringes.html
Medical researchMon, 02 Dec 2013 06:56:33 ESTnews305189736'Undruggable' mutation meets its match: Six-year effort yields first drug to target important cancer geneIn the field of drug design, the protein K-Ras is legendary. It's been on everyone's "target" list for more than 30 years due to its status as the most commonly mutated oncogene in human cancers. Despite this high profile, K-Ras has earned a reputation in scientific circles as being "undruggable" because many pharmaceutical, biotech, and academic laboratories have failed to design a drug that successfully targets the mutant gene.http://medicalxpress.com/news/2013-11-undruggable-mutation-six-year-effort-yields.html
CancerWed, 20 Nov 2013 13:00:05 ESTnews304174494Natural compound mitigates effects of methamphetamine abuseStudies have shown that resveratrol, a natural compound found in colored vegetables, fruits and especially grapes, may minimize the impact of Parkinson's disease, stroke and Alzheimer's disease in those who maintain healthy diets or who regularly take resveratrol supplements. Now, researchers at the University of Missouri have found that resveratrol may also block the effects of the highly addictive drug, methamphetamine.http://medicalxpress.com/news/2013-11-natural-compound-mitigates-effects-methamphetamine.html
NeuroscienceTue, 19 Nov 2013 13:07:37 ESTnews304088841Putting drug discovery back on target'The world urgently needs new medicines for many diseases such as Alzheimer's, depression, diabetes and obesity,' says Professor Chas Bountra. 'Yet the pharmaceutical industry's success rate for generating truly novel medicines remains low, despite investing tens of billions of dollars.'http://medicalxpress.com/news/2013-10-drug-discovery.html
Medical researchWed, 23 Oct 2013 10:10:01 ESTnews301741079Advanced technology for gene expression analysis can facilitate drug developmentWhen developing new drugs, monitoring cellular responses to candidate compounds is essential for assessing their efficacy and safety. Researchers from the RIKEN Center for Life Science Technologies report a new method to monitor and quantify the activity of gene promoters during the response to a drug, using the advanced gene expression analysis method CAGE followed by single-molecule sequencing. This research paves the way to a more precise analysis of cellular responses to drugs, at the level of individual promoters.http://medicalxpress.com/news/2013-10-advanced-technology-gene-analysis-drug.html
GeneticsThu, 03 Oct 2013 07:30:01 ESTnews300002623Team discovers patient-specific cure for dangerous heart rhythm disorderThe National Heart Centre Singapore (NHCS) research team has successfully and completely reversed the effects of the hERG (human ether-a-go-go-related gene) mutation in long QT syndrome 2 (LQTS 2) in patient-specific heart cells, scoring a world's first. Long QT syndrome 2 is a dangerous heart rhythm disorder that can lead to sudden cardiac death, even in young patients. It is caused by a mutation in a specific gene known as hERG, which helps to control the electrical activity in the heart cells and coordinate its beating rhythm. Using the patient's own skin stem cells transformed to beating heart cells, the team tested various drug compounds and discovered that the drug, not normally tested in this condition could reverse the effects of long QT syndrome 2. This novel experiment paves the way for the better understanding on how drugs affect cell and intra-cell disordered function and allows safe testing of new compounds on patients' own cells, without the risk of side effects to the patients themselves. The findings have earned the team a best poster prize at the prestigious ESC (European Society of Cardiology) Congress on 1 September 2013, the largest international cardiology meeting attended by close to 30,000 participants.http://medicalxpress.com/news/2013-09-team-patient-specific-dangerous-heart-rhythm.html
CardiologyTue, 17 Sep 2013 09:48:45 ESTnews298630111