2019-01-21T19:47:55Zhttp://repositori.uji.es/oai/requestoai:repositori.uji.es:10234/435242017-02-20T23:46:28Zcom_10234_7013com_10234_9col_10234_863800925njm 22002777a 4500dcMoles Tena, PamelaauthorOliva, MónicaauthorSafont Villarreal, Vicent Sixteauthor2008-09A theoretical study on the artemisinin decomposition mechanism is reported. The suggested pathways have been reproduced and the appearance of the final products can be explained in a satisfactory way. In addition, several intermediates and radicals have been found as relatively stable species, thus giving support to the current hypothesis that some of these species can be responsible for the antimalarial action of artemisinin and its derivatives.Tetrahedron, 64, 40, p. 9448-94630040-4020http://hdl.handle.net/10234/43524http://dx.doi.org/10.1016/j.tet.2008.07.086MalariaDFT calculationsTrioxane chemistryC-Radical intermediatesA theoretical study on the decomposition mechanism of artemisinin