Bayern Munich boss Carlo Ancelotti (pictured) coached Real Madrid to the 2014 Champions League crown and is up against his former assistant from that triumph, Madrid's current head coach Zinedine Zidane

(AFP/File)

Bayern's top-scorer Robert Lewandowski, with 38 goals in all competitions this season, is up against Portuguese superstar Cristiano Ronaldo, with 26 goals from 36 games.

That may be modest by his standards, but Ronaldo has tormented Bayern in the past with four goals in as many games and the Bavarians will be wary, especially with backup from Wales star Gareth Bale and France's Karim Benzema.

Lewandowski suffered a bruised shoulder in scoring twice in Saturday's 4-1 hammering of Borussia Dortmund, but expects to be "100 percent" fit.

Bayern are on a Champions League record of 16 straight European wins at the Allianz Arena and that's a record Dutch winger Arjen Robben is keen to maintain.

"We have to up the ante, we have to signal (to Real) from the first minute that there is nothing to take in Munich and we want to win the game," he said.

Bayern are looking to recover their 'bete noire' nickname, given to them by Real fans after Munich won eight of 14 matches against Real between 2000 and 2012.

'Sounds like a final'

Real Madrid's Cristiano Ronaldo eyes the ball during their UEFA Champions League match against Napoli, at the San Paolo stadium in Naples, on March 7, 2017

(AFP/File)

All that changed in the 2014 Champions League's semi-final when the team coached by Pep Guardiola was thrashed 4-0 in Munich, crashing out 5-0 on aggregate as Ronaldo and Sergio Ramos netted twice each.

That defeat remains Bayern's record home European loss, yet there is no talk of revenge ahead of Wednesday's clash.

"This is the quarter-finals, but it sounds like a final," said Bayern captain Philipp Lahm.

"We're playing against an absolute top team, who have top players in every position. We will have to play to our potential."

Both sides are missing key defenders, though.

Germany's Mats Hummels was ruled out after damaging ankle ligaments on Sunday so Jerome Boateng and Javi Martinez will form the centre-back partnership.

Hummels faces a race against time to be back for the return at the Santiago Bernabeu on April 18, while Real have defenders Pepe and Raphael Varane ruled out of both legs.

Pepe suffered a double rib fracture in Saturday's 1-1 draw with Atletico Madrid, while Varane is out for a month with a hamstring injury.

Right-back Daniel Carvajal trained on his own on Monday and is struggling with a knock.

Bayern received a boost on Monday with Germany goalkeeper Manuel Neuer back in training following a minor foot operation 10 days ago, while Thomas Mueller is also fit after an ankle injury.

"We're very confident. It's a European cracker featuring two top teams," said Mueller.

"We also notice it outside the club, not only in terms of the media, but also when talking to friends or acquaintances in Munich.