Cardinals @ Chargers: Matchups to Watch

What are the most critical matchups set to take place in San Diego? Find out here.

GAME PLAN: The Cardinals will need to at least be able to control the clock with the run. They have to keep the game close. With so many receivers hurt, the Cardinals should incorporate their backs and tight ends into the game plan more. The Cardinals are going to need some turnovers from their defense and perhaps a big special teams play to win this game.

Chargers TE Antonio Gates vs. Cardinals SS Adrian Wilson -- They won't be matched up all day but they will see each other plenty. If Wilson has a weakness in his game, it's defending tight ends in man coverage.

Chargers LT Brandyn Dombrowski vs. Cardinals OLB Joey Porter -- A natural guard, Dombrowski has played fairly well at left tackle this season. Porter will rush on every passing situation and had a sack and fumble caused last week.

INJURY IMPACT: WR Steve Breaston (knee) is out for at least two games after undergoing surgery to repair torn meniscus. The hope is that he can return after the bye on Oct. 17.

--LG Alan Faneca (back) was limited in practice this week but he is expected to play against the Chargers.

--RB Beanie Wells (knee) showed no recurring problems after making his season debut last week. Wells had 14 carries and appears ready for more work.

BY THE NUMBERS: 25-1 -- That's the Cardinals' record under Whisenhunt when leading after three quarters. They haven't lost a game under those circumstances since 2007 against Carolina.