The Wobbler mouse (wr) exhibits the loss of motoneurons especially in the cervical spinal cord, and thus has been studied as a model for human motoneuron diseases. Wobbler mice selected at various ages and stages during the disease process show increased levels of thyrotropin releasing hormone and substance P in spinal cord and brainstem (medulla). Enkephalins (methionine and leucine) also increase in the spinal cord and brainstem. Somatostatin increases in hypothalamus, perhaps accounting partly for the small size of this mutant mouse via its effect on growth hormone.

The Wobbler mouse (wr) exhibits the loss of motoneurons especially in the cervical spinal cord, and thus has been studied as a model for human motoneuron diseases. Wobbler mice selected at various ages and stages during the disease process show increased levels of thyrotropin releasing hormone and substance P in spinal cord and brainstem (medulla). Enkephalins (methionine and leucine) also increase in the spinal cord and brainstem. Somatostatin increases in hypothalamus, perhaps accounting partly for the small size of this mutant mouse via its effect on growth hormone.

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eng

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Elsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/brainres

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Brain Research

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NOTICE: this is the author’s version of a work that was accepted for publication in Brain Research. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Brain Research, [VOL 518, ISSUE 1-2, 1990] DOI 10.1016/0006-8993(90)90992-K

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enkephalin

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motoneuron disease

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radioassay

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somatostatin

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substance P

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thyrotropin releasing hormone

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Wobbler mice

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Brain - growth and development

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Motor Neurons - physiology

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Neuromuscular Diseases - physiopathology

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Neuropeptides - analysis

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Spinal Cord - analysis - growth and development

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dc.title

Measurement of neuropeptides in the brain and spinal cord of Wobbler mouse: A model for motoneuron disease