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Physicochemical Properties and Membranolytic Activities of the Titanium Dioxide Polymorphs Compared with Those of Quartz.

Authors

Nolan-RP; Langer-AM; Herson-GB

Source

Biological Interaction of Inhaled Mineral Fibers and Cigarette Smoke, Proceedings of an International Symposium/Workshop, Seattle, Washington, April 10-14, 1988 1989:391-419

Link

NIOSHTIC No.

00225033

Abstract

A comparative study was conducted on the physicochemical properties and membranolytic activities of titanium-dioxide (13463677) (TiO2) polymorphs rutile (1317802) and anatase (1317700), and quartz (14808607). Three rutile specimens from Du Pont (R-100, R-900, and R-960), the rutile IOM-1, and an anatase sample were used for the study and compared with three quartz specimens (DQ12, F600, and Min- U-Sil). Particle characterization was performed by optical microscopy, size distribution measurements, and X-ray diffraction analysis. All synthetic TiO2 were in the respirable size range as revealed by particle size distribution measurements. Specimens were subjected to a human erythrocyte hemolytic model for a quantitative determination of their membranolytic potential. Determinations of hydrogen bonding to 2-poly(vinylpyridine-N-oxide) (2-PVPNO) were also made. All the Du Pont specimens were found to be membranolytically active and inhibited by 2-PVPNO. The anatase and rutile IOM-1 were found to be inert. Heating for 6 hours up to 600 degrees-C markedly decreased the membranolytic potential of the TiO2 samples. Quartz samples with a finer size distribution bound more 2- PVPNO, which also inhibited their membranolytic potential. Heating of the quartz samples only reduced their membranolytic abilities slightly. The authors conclude that such results may explain the fundamental mechanisms of interaction between respirable particles and biological systems.