If you wish to use HW UART instead of the USB cable, it’s perfectly possible … you just need to do a bit more work to free the UART up on your Pi.

To get started, hook the GPS module up to your Pi as follows, cross-connecting the TX and RX pins (TX on one device goes to RX on the other and vice versa), and supply 5V from the Pi to the VIN pin on the GPS module…