NBRP Genome Information Upgrading Program Project's Progress

Rats

Focus

Whole genome resequencing of the representative rat strains and development of a SNP typing kit

Principal Investigator

Mikita Suyama Kyushu University

Project Period

FY2016

Overview

Rats have been used as animal models of human diseases such as cancer and hypertension. NBRP-Rat is the largest
repository for the rat strains, and currently about 700 strains are registered in the repository. Among those strains,
there are many rat models of immune-mediated disorders and cancers.
This project focuses on whole genome resequencing of the representative rat strains, which include 12 strains of
the representative inbred rats, one strain of the inbred rats originated from the wild populations, and seven strains of
disease models derived from selective breeding. Based on the SNP
information obtained by the whole genome resequencing, we will
also develop a SNP typing kit that can be used for linkage analyses
to detect responsible loci of diseases and for quality control of
registered strains by detecting genetic contamination. This project
is conducted in the collaboration with The Institute of Laboratory
Animals, Graduate School of Medicine, Kyoto University, which
is the NBRP Center for rat strains, and Kazusa DNA Research
Institute. The genomic data obtained by this project, together with
the development of a SNP typing kit based on the genomic data,
will be of help to the researchers in the field of rat genetics.

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