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There is a MAJOR health interaction between the two being combined. Please, do not mix the two, it's very dangerous.

*Talk to your doctor before using venlafaxine together with methamphetamine. Venlafaxine can increase the effects of methamphetamine, and side effects such as jitteriness, nervousness, anxiety, restlessness, and racing thoughts have been reported. Combining these medications can also increase the risk of a rare but serious condition called the serotonin syndrome, which may include symptoms such as confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea. You should contact your doctor immediately if you experience these symptoms while taking the medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

I am also taking 150 mg of Venlafaxine a day and my husband and I have smoked crystal a few times over the past couple of months. I have noticed that my come down symptoms are stronger than his are and last a bit longer; however, he has a higher tolerance for drugs than I do so I wasn't sure if it were due to that.

I know that my sister does mix the two with little to no negative repercussions, besides the very first time mixing them. Before she knew her limit on mixing the two my sister ended up snorting more meth than usual (not uncommon, usually with regular comedown) one day after starting effexor and ended up vomiting for many hours afterwards. She became dizzy, irritable, as well as most symptoms associated with a common flu. It was deduced that my sister possible had serotonin syndrome, though it was never professionally confirmed. However, the effects on her personality and emotional tolerance drastically changed, reverting to worsened depression and anxiety to which the venlafaxine was originally prescribed for.
Just as a precaution, I would recommend that you start slow and wait longer periods before hitting up than usual for yourself. Maybe take a small hit then wait to see how your body reacts/feels afterwards. Like always, it is very important to stay hydrated and to force yourself to eat healthy food every 3-4 hours.