20th century-era maps of Africa were stored in the USS Enterpriselibrary computer in 2254. One map depicted Africa in the eastern hemisphere. Another map depicted the globe from the point of view of the Arctic Circle, showing the northern hemisphere, including the north coast of Africa. These maps were among the materials viewed by the Talosians when they scanned the Enterprise computer. (TOS: "The Cage")

During the Eugenics Wars, North Africa was a theater of battle. CaptainJonathan Archer's great-grandfather was involved in a campaign in North Africa. During that conflict, he contacted enemy forces in a successful effort to allow some non-combatant civilians time to get to safety. (ENT: "Hatchery")

According to an Original Series writer's guide, Uhura was born in 2239 in the "United States of Africa". However, no on-screen evidence for the existence of this political entity has ever been established.

The script of Star Trek explained that at the time of Kirk's corvette incident, his mother was in Africa.

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