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Publications31

Review: The biological basis of antipsychotic response in schizophrenia

James M StoneInstitute of Psychiatry, King s College London, London SE5 8AF, UKJ Psychopharmacol 24:953-64. 2010

..In this selective review we summarise research findings investigating the biological differences between patients with schizophrenia who show a good or a poor response to treatment with antipsychotic drugs...

Non-uniform blockade of intrastriatal D2/D3 receptors by risperidone and amisulpride

..Ketamine induces effects resembling both positive and negative psychotic symptoms of schizophrenia. These are thought to arise through its action as an uncompetitive antagonist of the N-methyl-D-aspartate (NMDA) receptor...

..We consider the case for glutamatergic excitotoxicity as a key process in the development and progression of schizophrenia, and suggest ways in which glutamate and dopamine dysregulation may interact in the condition...

[123I]TPCNE--a novel SPET tracer for the sigma-1 receptor: first human studies and in vivo haloperidol challenge

James M StoneInstitute of Psychiatry, King s College London, London, UKSynapse 60:109-17. 2006

..A region in which binding was unaffected by haloperidol pretreatment could not be identified, and the time-activity data were best described by an irreversible model...

..We used [123I]CNS-1261 to determine whether binding to the NMDA receptor intrachannel PCP/MK-801 site is affected by schizophrenia or by treatment with typical antipsychotics and clozapine in vivo...

..6 ± 18.9%) compared with the CBD group (-0.4% ± 9.7 %) (t=2.39, p<0.05). These findings support the idea that high-THC/low-CBD cannabis products are associated with increased risks for mental health...

Substance use and regional gray matter volume in individuals at high risk of psychosis

James M StoneDepartment of Psychosis Studies, Institute of Psychiatry, King s College London, United KingdomEur Neuropsychopharmacol 22:114-22. 2012

..However, alcohol, tobacco and cannabis at low to moderate intake may be associated with lower gray matter in both ARMS subjects and healthy volunteers-possibly representing low-level cortical damage or change in neural plasticity...

Disruption of frontal θ coherence by Δ9-tetrahydrocannabinol is associated with positive psychotic symptoms

..Here, we review the contribution of imaging studies to date in understanding glutamatergic abnormalities in psychosis, and discuss the potential of new glutamatergic compounds for treatment of the disorder...

..We suggest that this orthogonality is compromised in early psychosis, explaining similarities between its phenomenology and that of the psychedelic state and supporting the utility of psilocybin as a model of early psychosis. ..

Neuroanatomical abnormalities that predate the onset of psychosis: a multicenter study

..Here in a critical review, we appraise the major findings from recent intravenous cannabinoid studies in humans and trace the historical roots of this work back to the 1970's...

Glutamate dysfunction in people with prodromal symptoms of psychosis: relationship to gray matter volume

James M StoneInstitute of Psychiatry, King s College London, University College London, United KingdomBiol Psychiatry 66:533-9. 2009

..Here we determine whether changes in brain glutamate are present in subjects at ultra high risk of developing psychosis and whether these changes are related to reductions in cortical gray matter volume...

Opposite effects of delta-9-tetrahydrocannabinol and cannabidiol on human brain function and psychopathology

..Delta-9-THC and CBD can have opposite effects on regional brain function, which may underlie their different symptomatic and behavioral effects, and CBD's ability to block the psychotogenic effects of Delta-9-THC...

The contribution of brain imaging to understanding the mechanism of second generation antipsychotic drugs

..Online tools offer the possibility of visualizing and exploring completely digitized sections of brains at a sub-neuronal level and can facilitate large-scale connectional tracing, histochemical, and stereological analyses...