Participants undergo routine colposcopy as part of their regular colposcopic evaluation. The digital colposcope is used to take fluorescence and reflectance images of the vagina and cervix. Participants also undergo loop electrosurgical excision procedure (LEEP). The digital colposcopic images are compared with tissue removed during LEEP. Additional surrogate biomarkers under development are also measured using tissue samples removed during LEEP, such as quantitative histopathology measurements, DNA tests for the copy number changes, and tests for the incorporation of viral HPV DNA.

Eligibility

Ages Eligible for Study:

19 Years and older (Adult, Senior)

Genders Eligible for Study:

Female

Accepts Healthy Volunteers:

No

Criteria

Criteria:

Inclusion criteria:

Included subjects will be ≥18 years old.

Included subjects will not be pregnant.

Included subjects will have a negative urine pregnancy test.

Included subjects will be scheduled for colposcopy and/or LEEP treatment at the VGH Women's Clinic.

Included subjects will indicate understanding of the study.

Included subjects will provide informed consent to participate.

Exclusion criteria:

Individuals <18 years old will be excluded.

Pregnant individuals will be excluded.

Individuals that have had an operation to remove their cervix will be excluded.

PRIOR CONCURRENT THERAPY:

See Disease Characteristics

Contacts and Locations

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study.
To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below.
For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00602368