Assistant Professor, Child and Adolescent Psychiatrist, Neuroscience Research Center, Institue of Neuropharmacology AND Department of Psychiatry, Afzalipour School of Medicine, Shahid Beheshti Hospital, Kerman University of Medical Sciences, Kerman, Iran.

Abstract: (2077 Views)

Selective serotonin reuptake inhibitors (SSRIs) are reported to be associated with increased bleeding
tendency. While findings of recent studies explain a lot about the pathophysiology of this side-effect, there is a
general tendency to discontinue SSRIs as harmful medications. We report two instances of dose-dependent
relations between sertraline and bleeding tendency. Bleeding diathesis was alleviated by adjusting dosage of
medication. It could be argued that benefits of SSRIs could outweigh this potential and probably avoidable sideeffect
if dose-adjustment is properly implemented.