The Nyctalope possessed enhanced night vision, special color-shifting irises, and an artificial heart. "Nyctalopics" is a term that describes the process of cybernetic adaptation.

Also there is a reference in Twenty Thousand Leagues Under the Sea by Jules Verne; Chapter 5: "Day and night they watched the surface of the ocean, and even nyctalopes, whose faculty of seeing in the darkness multiplies their chances a hundredfold, would have had enough to do to gain the prize."

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The Nyctalope has appeared in several short stories published in the anthologyTales of the Shadowmen and two collections of new stories written by other writers, The Nyctalope Steps In (2011) and Night of the Nyctalope (2012).