Sam & Max: Season Two

This is a "point-and-click" adventure game in which players control two private detectives: a wily dog named Sam and a sarcastic rabbit called Max. Through five episodes of mystery case-solving, players encounter several irreverent characters who make jokes about the following: size being too big to fit into a hole, followed by "That's what she said"; sexual harassment posters (e.g., "I've touched all of those places"); zombies with nipple rings; the seduction of women to conceive "hellspawn"; and drugs at raves. Cutscenes also contain bathroom humor, including a depiction of a character that urinates a stream of fire at the heroes. Characters sometimes use the expletives "a*s" and "bastard," as well as profanities that are beeped, bleeped, and censored. During one episode, players must win a boxing mini-game against rats residing inside a robot. Another episode depicts Sam shooting a pistol at "cartoony" characters, and Max chewing on a man's forehead.

Intro and short clip from the Sam&Max animated series.
It ran for 24 episodes on FOX Kids in 1997-1998. The show was more tailored to kids in comparison to the original games, though some mature humor did make it into the show.
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