'The Big Bang Theory' Officially Ending After Season 12

Warner Bros. Television and CBS announced Wednesday that the beloved comedy will end its run in May 2019, making it the longest-running multi-camera series in TV history.

The show — which debuted in 2007, airs in syndication around the world, and has received 52 Emmy nominations and 10 wins to date — will conclude at the end of the upcoming season 12, with 279 episodes.

In a joint statement, Warner Bros. Television, CBS and Chuck Lorre Productions said, “We are forever grateful to our fans for their support ofThe Big Bang Theoryduring the past twelve seasons. We, along with the cast, writers and crew, are extremely appreciative of the show’s success and aim to deliver a final season, and series finale, that will bringThe Big Bang Theoryto an epic creative close.”

Speaking to PeopleTV on the Paleyfest red carpet in March, the cast admitted they couldn’t really picture their life after the series finale.

“I actually can’t, to be honest,” said Cuoco. “I can’t really picture it. And I don’t think there really will be my life without it — I think it’ll always be there, I think it’ll always be running, I think we’ll always have those fans. It’s always going to be a part of me.”