16
Intensive BP management reduced the rate of two closely correlated secondary end points: total stroke (p=0.01) and nonfatal stroke (p=0.03). Assuming that this finding was real, the number needed to treat to the lower SBP level to prevent one stroke over 5 years was 89. These effects would be consistent with meta-analyses summarizing the impact of a 10 mm Hg reduction in SBP on strokes from observational studies (relative risk=0.64) and drug treatment trials (relative risk=0.59).

18
The ACCORD BP trial evaluated the effect of targeting a SBP goal of 120 mm Hg, compared to a goal of 140 mm Hg, in patients with type 2 diabetes at increased cardiovascular risk. The results provide no conclusive evidence that the intensive BP control strategy reduces the rate of a composite of major CVD events in such patients.