What it does: It is an anti-alcoholic agent that makes drinking of alcohol or use of cocaine highly unpleasant.

How it works: It increases acetaldehyde in the blood

Side effects: Nausea, vomiting (sometimes very severe, if any alcohol or cocaine is used), rapid heart rate, difficulty breathing, low blood pressure, confusion and fainting. For a more complete list of side effects see this NIH page.

What it does: Promotes longer total sleep time and decreases daytime sleepiness in abstinent cocaine users

How it works: May increase the release of dopamine in the brain's reward center

Side effects: Anxiety, depression, diarrhea, dizziness, dry mouth, headache. Modafinil should be avoided by people with certain types of heart disease such as mitral valve prolapse.
For a more complete list of side effects see this NIH page.

Availability: Physician prescription

Warning: A schedule 4 drug with potential for addiction

Research: American Journal of Psychiatry. 2010; 167(3):331-40. Normalizing effects of modafinil on sleep in chronic cocaine users. Progressive abstinence from cocaine was associated with worsening sleep. Modafinil taken in the morning produced longer total sleep time and shorter time to fall asleep in the third week of abstinence.