⚈ Start with released copy of my.cnf / my.ini.
⚈ Set key_buffer_size and innodb_buffer_pool_size according to engine usage and RAM.
⚈ Slow queries can usually be ‘fixed’ via indexes, schema changes, or SELECT changes, not by tuning.
⚈ Don’t get carried away with the Query cache until you understand what it can and cannot do.
⚈ Don’t change anything else unless you run into trouble (eg, max connections).
⚈ Be sure the changes are under the [mysqld] section, not some other section.

ZeroMQ
: ØMQ (ZeroMQ, 0MQ, zmq) looks like an embeddable networking library but acts like a concurrency framework. It gives you sockets that carry whole messages across various transports like in-process, inter-process, TCP, and multicast. You can connect sockets N-to-N with patterns like fanout, pub-sub, task distribution, and request-reply. It’s fast enough to be the fabric for clustered products. Its asynchronous I/O model gives you scalable multicore applications, built as asynchronous message-processing tasks. It has a score of language APIs and runs on most operating systems. ØMQ is from iMatix and is LGPL open source.
: http://www.zeromq.org/