lipoic acid

li·po·ic ac·id

(li-pō'ik as'id),

A bacterial growth factor present in yeast and liver extracts; may be useful in the treatment of mushroom poisoning. Functions as the amide (lipoamide) cofactor in the disulfide (-S-S-) form in the transfer of "active aldehyde" (acetyl), the two-carbon fragment resulting from decarboxylation of pyruvate from α-hydroxyethylthiamin pyrophosphate to acetyl-CoA, itself being reduced to the dithiol form (that is, dihydrolipoic acid) in the process. Lipoic acid is also an essential component of other α-keto acid dehydrogenase complexes.

lipoic acid

/lipo·ic ac·id/ (lip-o´ik) a necessary cofactor for several enzyme complexes involved in the oxidative decarboxylation of keto acids, where it occurs in the form lipoamide. It is used as a dietary supplement for its antioxidant properties.

lipoic acid

(lĭ-pō′ĭk)

n.

An organic acid, C8H14S2O2, that is essential for decarboxylation of pyruvate to acetyl coenzyme A during aerobic metabolism. It is also used as a dietary supplement for its antioxidant properties.

lipoic acid

[lipō′ik]

a bacterial growth factor found in liver and yeast.

lipoic acid

a vitamin prosthetic group in enzymes involved in oxidative decarboxylation of keto acids such as 2-oxoglutarate and pyruvate. Called also α-lipoic acid, thioctic acid.

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