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2009 February

Impaired Notch fucosylation in early mouse development

Post-translational fucosylation of Notch is catalyzed by protein O-fucosyltransferase 1 (POFUT1), and is essential for Notch function in early mouse development. A spontaneous mutation of the mouse gene Pofut1, referred to as 'compact axial skeleton' (cax), results in reduced Notch signaling. Neuronal differentiation, however, appears to be unaffected in cax mutant mice (Pofut1cax/cax) at E9.5, as indicated by the normal expression of the neuronal marker, NeuroD (blue) in whole mount in situ hybridization.