She started writing children's science fiction in the 1970s. She was married to Isaac Asimov from 1973 until his death in 1992, and they collaborated on a number of science fiction books aimed at young readers, including the Norby series. She died in February 2019 at the age of 92.[2][3]

Janet Asimov's first published writing was a "mystery short" sold to Hans Stefan Santesson for The Saint Mystery Magazine, which appeared in the May 1966 issue.[4] Her first novel was The Second Experiment in 1974;[5] Asimov wrote mostly science fiction novels for children throughout her career.[6] As a psychiatrist she incorporated aspects of psychoanalysis, human identity, and other psychiatry-related ideas in her writing.[6] According to Isaac Asimov, the books that Janet Asimov wrote in association with him were 90 percent Janet's, and his name was wanted on the books by the publisher "for the betterment of sales".[7] After Isaac's death, she took on the writing of his syndicated popular-science column in the Los Angeles Times.[2][8]

Janet Jeppson began dating Isaac Asimov in 1970 immediately following his separation from Gertrude Blugerman.[9] They were married on November 30, 1973, two weeks after Asimov's divorce from Gertrude.[10] Despite Jeppson's upbringing in The Church of Jesus Christ of Latter-day Saints,[11] their marriage was officiated by a leader of Ethical Culture, a religion that Janet later joined.[12] Their marriage lasted until Isaac's death in 1992 from complications relating to HIV, contracted from a 1983 blood transfusion during bypass surgery.[13] Janet reportedly consulted medical texts after Isaac began exhibiting symptoms, and she requested an HIV test be performed. His doctors insisted she was wrong and only tested Isaac for the infection after he became seriously ill. She wanted the information made public, but doctors insisted upon not disclosing it, even after Isaac died. After the doctors demanding silence had all passed away, Janet Asimov went public with the knowledge.[14]