1. Three methoxyamphetamine analogues have been incubated with Cunninghamella echinulata under different environmental and nutrient conditions. 2. The biotransformation of 4-methoxyamphetamine was inhibited by cobalt; the carbon source and other trace metals had no effect. The rate of biotransformation of 4-methoxyamphetamine and formation of… (More)

When incubated alone for 7 days with the fungus Cunninghamella echinulata, tranylcypromine was extensively metabolized. As observed in mammalian systems, N-acetyltranylcypromine was the major metabolite recovered along with lesser amounts of 4-hydroxytranylcypromine, as its N,O-diacetyl derivative. The rate and extent of tranylcypromine biotransformation… (More)

1. Biotransformation studies with five concentrations of racemic propranolol were conducted using the filamentous fungus Cunninghamella echinulata ATCC 9244. 2. The rate of formation and subsequent disappearance of a new major metabolite, 8-hydroxypropranolol, was dose-dependent. Desisopropylpropranolol and 4-hydroxypropranolol were also formed.… (More)

Three-component lamellar phase has been investigated which consists of C12E5 , octane and water . This is a layered phase, the lyotropic equivalent of a thermotropic smectic-A phase. X-ray scattering techniques were used on powder and aligned samples, as well as the optical microscopy investigations to understand the structure and the interactions that… (More)

The urinary elimination of 4-hydroxyamphetamine (PHA) and a series of homologous 4-alkoxy-substituted amphetamines and their metabolites was examined after single and multiple oral administration to pregnant and non-pregnant mice. The metabolic profile and extent of biotransformation in a series of alkoxy analogues were affected by the size of the alkoxy… (More)

Surfactants in solution can spontaneously self-assemble to form interfacial monolayers which separate mesoscopic regions of water and oil. The statistical mechanics of the surfactant monolayers can explain the rich phase behavior and novel physical properties of microemulsion systems. Here we use x-ray reflectivity to study the intrinsic properties of a… (More)