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Rex, for whom the show is named, is an EVO--a genetic monster made by Nanites, tiny machines in every living thing that were originally made to cure diseases, but now alter DNA--working for providence. Rex lives in Providence headquarters, along with Bobo Haha and Agent Six. As a providence agent, he fights EVOs that threaten humanity, such as Van Kleiss and the pack, consisting of Biowulf and Skalamander. Rex has the special ability to control his Nanites,and can use them to create weapons or means of transportation.