Sophion is thrilled to announce the upcoming release of the newest state-of-the-art
instrument for direct patch clamp assays on ion channels, the Qube. This is Sophion’s next
generation high-throughput system for ion channel screening, intended for use in
laboratories with a need for thousands of data points per day. The Qube finally bridges the
gap between high-throughput and high quality in ion channel assays and allows for a
faster drug discovery process.

“The Qube offers the same uncompromising high data quality as our QPatch and with a
previously unseen low cost per data point. With the Qube, Sophion accommodates the
need pharmaceutical companies have to screen large compound libraries to find compound
leads for ion channel targets”, says Torsten Freltoft, CEO at Sophion Bioscience, and he
continues: “By virtue of it being the highest-throughput automated patch clamp system to
date, the Qube provides access to high quality data earlier in the drug discovery process
than ever before, thereby making the process more efficient”.

The Qube can be used for primary and secondary screening of any ion channel of interest.
Sophion’s vast experience with planar patch clamp from the QPatch products has been
utilized to create gigaseal recording substrates and flow channels for liquid exchange in
the Qube measurement plates. With 384 parallel measurement sites and as little as 10-15
minutes per plate run, the Qube enables testing more than 1500 compounds in a single
hour. With full automation features – a plate stacker and cell preparation unit – for
unattended operation, the system provides walk-away time, which the scientist can use for
other important tasks. The Qube is easy to operate with user-friendly software for
experiment setup, automated data analysis and data export.

Sophion Bioscience, a leader in the automated patch clamp field, helps the pharmaceutical industry develop more
and better drugs, faster. Sophion’s focus is to provide advanced products and integrated solutions for automated
patch clamping. Sophion’s family of products provides high-quality patch clamp data on a truly industrial basis on
all types of ion channels. Sophion is now part of Biolin Scientific, a Swedish materials science company providing
high-tech precision instruments for research within surface-, material- and bio-science, drug discovery and
diagnostic applications. For more information about Sophion please visit www.sophion.com. For more information
about Biolin Scientific, please visit www.biolinscientific.com