Summariesfor CHKB gene

Choline kinase (CK) and ethanolamine kinase (EK) catalyze the phosphorylation of choline/ethanolamine to

phosphocholine/phosphoethanolamine. This is the first enzyme in the biosynthesis of

phosphatidylcholine/phosphatidylethanolamine in all animal cells. The highly purified CKs from mammalian sources

and their recombinant gene products have been shown to have EK activity also, indicating that both activities

reside on the same protein. The choline kinase-like protein encoded by CHKL belongs to the choline/ethanolamine

kinase family; however, its exact function is not known. Read-through transcripts are expressed from this locus

that include exons from the downstream CPT1B locus. (provided by RefSeq, Jun 2009)

GeneCards Summary for CHKB Gene:

CHKB (choline kinase beta) is a protein-coding gene. Diseases associated with CHKB include spermatic cord torsion, and japanese spotted fever. GO annotations related to this gene include ethanolamine kinase activity and choline kinase activity. An important paralog of this gene is CHKA.