Adenosine plays a major modulatory and neuroprotective role in the mammalian CNS. During cerebral metabolic stress, such as hypoxia or ischemia, the increase in extracellular adenosine inhibits… (More)

A phospholipase A2 with a molecular mass of 12–14 kDa has been isolated from the venom of the spiderEresus niger by three-stage column chromatography. Asparagine has been identified as the N-terminal… (More)

The actions of crude venom from Anemesia species of spider were investigated in cultured dorsal root ganglion neurones from neonatal rats and hippocampal slices. Using mass spectrometry (MALDI-TOF… (More)

It has been shown previously that the venom of the spider Eresus niger effectively blocks the nerve-muscle synapses of the frog, interacting at the level of the presynaptic membrane [1]. An analysis… (More)

Phospholipase A, named component EnPA, was isolated from Eresus niger spider venom. It was determined to be a single peptide chain with mol. wt of 13,000. Component EnPA showed high anticoagulant… (More)

Excitatory synaptic transmission in area CA1 of the mammalian hippocampus is rapidly depressed during hypoxia. The depression is largely attributable to an increase in extracellular adenosine and… (More)