↵a Activities of CLR (200 mg/kg/day), MXF (100 mg/kg/day), GAT (100 mg/kg/day), LVX (200 mg/kg/day), and FQ-CLR combinations against MAC-infected mice. Viable bacterial counts were determined in the lungs, liver, and spleen 48 h after completion of therapy. A total of five mice were examined per group, and each value represents the mean ± standard error of the mean. Significant differences (P < 0.05) in viable bacterial numbers between treatments with each FQ alone and with FQ-CLR combinations (e.g., MXF versus MXF-CLR) were obtained for all target organs. The experiment was performed twice, and the data shown are from the second experiment. Similar results and statistical tendencies were obtained from the first experiment.