"Disappointment," she says with a pout, before a big smile begins to spread across her face. "What happened to mine? That's what I want to know. What happened to my nomination?"

And what about the old team spirit?

Heigl, Dr. Izzie Stevens on "Anatomy," pauses for a second and laughs. "Screw them."

Taking a pause on the Brentwood set of the Judd Apatow's "40 Year-Old Virgin" follow-up "Knocked Up," Heigl is able to move beyond her feigned disappointment to admit that she's been in touch with both of her nominated co-stars, Chandra Wilson and Sandra Oh.

"I talked to Chandra and they're over in Europe right now doing publicity for the show and she's sort of kind of like dumbstruck right now," Heigl says. "I was like 'How do you feel? Are you excited?' And she was like 'I don't know. I don't know how I feel yet.' It's just so deserving. She's so unbelievably talented and has worked long and hard in this industry like the rest of us and I'm just really, really proud of her."

She continues, "I have not gotten hold of Sandra yet, but I think Sandra is probably up to her eyeballs in rehearsals and performances in New York for her play that she's doing, but again, just another person who's really so talented and so deserving. But I wonder if this year she's like, 'Eh, this is old hat. I was nominated last year. Whatever.' I wonder if you ever get like that."

For her part, Heigl is just enjoying the perks of being on a hit TV series, like the chance to have the female lead in a big studio comedy. "Knocked Up" isn't expected to be released until next summer, but it's already eaten up all of Heigl's hiatus this summer.

"I can't even imagine going back to work in two weeks on 'Grey's,'" she sighs. "I'm exhausted. I do think it's one of those situations, my agent likes to say it's a high-class problem. I spent a lot of years out of work, so I'd rather be tired and over-worked than bored and under-worked. It's been an amazing year."

Certainly she has loose ends to tie up when shooting begins again. Last season's two-part finale left many "Anatomy" fans frustrated at Izzie's ill-fated decisions regarding Jeffrey Dean Morgan's soulful heart-transplant patient Denny Duquette, a choice that makes her character's medical future uncertain as the new season begins. Heigl's heard a variety of reactions from fans.

"People are angry and people are sympathetic," she says. "It kind of runs the gamut."

She continues, "I'm actually more angry than sympathetic. I can't believe she threw her career away. I just can't believe it."

So all of the viewers who felt incredulous and waved fists at their TVs in impotent rage have an ally in Heigl, though the actress understands why showrunner Shonda Rhimes and the rest of the creative team went in that direction.

"It was a great sort of creative choice," she admits. "As far as acting goes, it was great drama. But because I know the character so well and she's worked so unbelievably hard to be taken seriously as a doctor and all the years of schooling to get there, I was so devastated. Is like, 'Noooooo... She's worked too hard to throw it all away. She doesn't even know him!' But it was good drama."

But don't expect any hints from Heigl on where things are going this fall.

"Not only can I not tell, but I don't know myself, so it's one of those conversations where you're just like, 'I don't know! I'd just keep watching. Keep watching! We've moved to Thursday nights, so keep watching!'"