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Knocked Up may have established Seth Rogen as a bonafide leading man, but the star has since demonstrated a strong comedic range. Whether it's the over-the-top stoner comedy of Pineapple Express or his surprisingly heartfelt supporting role in 50/50, Rogen has honed his ability to bring the heart of a film to life without sacrificing the laughs. Case in point, the actor's latest comedy, The Guilt Trip, looks to focus on the relationship between mother and son.

In the film, Rogen plays inventor Andy Brewster, who invites his mom (played by Barbra Streisand) on an eight-day cross-country trip to promote his latest invention. Along the way, hilarity ensues and, we can assume, the pair develop a closer relationship and a better understanding of each other as a result.

There's nothing particularly ground-breaking about that premise, as countless films have previously shown friends and/or family members bond over the crazy misadventures they encounter on the road. However, the above trailer, courtesy of Yahoo! Movies, does at least indicate that Rogen and Streisand will share strong on-screen chemistry as they trade one-liners. This road trip structure of the film can be hit-and-miss, but the script by Dan Fogelman (Crazy, Stupid, Love, Tangled) looks like it will wisely avoid the temptation to insert overly crude humor in place of actual jokes and will instead let the laughs develop out of the emotional arc in the relationship between its two leads.

The Guilt Trip also marks Streisand's first role since Little Fockers (2010) and her first non-sequel since The Mirror has Two Faces (1996). Hopefully, this is a sign that the script was strong enough to lure her back to theaters. If nothing else, the potentially schmaltzy family-centric plot will win over fans of director Anne Fletcher's previous films, such as The Proposal and 27 Dresses.

Will you be checking out The Guilt Trip, Screen Rant readers? Let us know in the comments.