Indications for VRAYLAR:

Manic or mixed episodes associated with bipolar I disorder.

Adult:

Initially 1.5mg once daily; increase to 3mg on Day 2; may further adjust by 1.5mg or 3mg increments based on response and tolerability; max 6mg/day. Usual range 3–6mg once daily. Initiating a strong CYP3A4 inhibitor while on Vraylar: reduce Vraylar dose by ½. Initiating Vraylar while already on a strong CYP3A4 inhibitor: give 1.5mg on Days 1 and 3 (no dose on Day 2), then 1.5mg daily from Day 4 onward; increase to max 3mg daily. May need to increase Vraylar dose after withdrawing inhibitor.

Generic Availability:

NO

How Supplied:

Caps—30, 90; Blister packs—7 (1.5mg × 1 + 3mg × 6)

Indications for VRAYLAR:

Schizophrenia.

Adult:

Initially 1.5mg once daily; increase to 3mg on Day 2; may further adjust by 1.5mg or 3mg increments based on response and tolerability; max 6mg/day. Usual range 1.5–6mg once daily. Initiating a strong CYP3A4 inhibitor while on Vraylar: reduce Vraylar dose by ½. Initiating Vraylar while already on a strong CYP3A4 inhibitor: give 1.5mg on Days 1 and 3 (no dose on Day 2), then 1.5mg daily from Day 4 onward; increase to max 3mg daily. May need to increase Vraylar dose after withdrawing inhibitor.