In this paper, the flow characteristics of the whole-rounded enlarged-hole baffle heat exchangers are experimentally studied with the stress on the shell-side pressure drops. It is found that the shell-side pressure drops for the whole-rounded baffles with the enlarged holes are greatly decreased. Compared with the square layout, the enlarged-hole whole-rounded baffles in the case of triangle layout is even more effective in decreasing the pressure drop. The shell-side pressure drops for the heat exchangers with the enlarged-hole whole-rounded baffles are proportional to the square of the flow rate.