Effect of resistance training on inflammatory markers of older adults: A meta-analysis.CONCLUSIONS: Anti-inflammatory effects of RT were significant only for CRP with a tendency for a decrease in IL-6 as well. The exploratory analyses suggested the reduction in inflammatory markers could be dependent on increases in muscle mass and higher volume of RT protocols. These potential mediators of RT anti-inflammatory effects should be addressed in future meta-analyses to clarify the effects of RT on inflammatory markers of older adults with very specific conditions and larger numbers of studies.
PMID: 30071283 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)Source: Experimental Gerontology - July 30, 2018 Category: Geriatrics Authors: Sardeli AV, Tomeleri CM, Cyrino ES, Fernhall B, Cavaglieri CR, Chacon-Mikahil MPT Tags: Exp Gerontol Source Type: research

Specific alterations in the circulating levels of the SIRT1, TLR4, and IL7 proteins in patients with dementia. Abstract
Sirtuins have gained considerable attention as epigenetic regulators for slowing aging and age-related disorders. The growing association between neurodegeneration and inflammation has led researchers to investigate interactions of sirtuins with inflammatory markers in neurodegenerative diseases. We analyzed SIRT1's association with chronic inflammation in dementia as an age-related neurodegenerative condition through Toll-like receptor 4 (TLR4) and interleukin-7 (IL7) for the first time. In the present study, we observed a significant increase in the level of SIRT1 in patients with all types of dementia....Source: Experimental Gerontology - July 30, 2018 Category: Geriatrics Authors: Kilic U, Elibol B, Uysal O, Kilic E, Yulug B, Sakul AS, Yildiz GB Tags: Exp Gerontol Source Type: research

Effects of aging on the biomechanics of Coquerel's sifaka (Propithecus coquereli): Evidence of robustness to senescence.This study examines a nonhuman primate model to evaluate its relevance to understanding human aging processes. To test the null hypothesis that age-related changes in joint function and gait do occur in primate models in a similar fashion to humans, a detailed gait analysis, including velocity, footfall timings, and vertical ground reaction forces, on bipedal locomotion was performed in Coquerel's sifaka (Propithecus coquereli), ranging in age from 5 years to 24 years. None of the spatiotemporal or kinetic gait variables measured was significantly correlated with age alone. There was a slight but significant reduction ...Source: Experimental Gerontology - July 30, 2018 Category: Geriatrics Authors: Snyder ML, Schmitt D Tags: Exp Gerontol Source Type: research

The impact of age-related hearing loss and lateralized auditory attention on spatiotemporal parameters of gait during dual-tasking among community dwelling older adults.nda C
Abstract
This investigation assessed the impact of hearing loss and lateralized auditory attention on spatiotemporal parameters of gait during overground dual-tasking by the use of the dichotic listening task. Seventy-eight right-handed, healthy older adults between 60 and 88 years were assigned to a Young-Old (71 years) group. Cognitive assessment and pure tone audiometry were conducted. Spatiotemporal parameters of gait quantified by mean (M), and coefficient of variations (CoV) were evaluated with the OptoGait system during 3 dichotic listening conditions: Non-Forced, Forced-Right and Forced-Left. Fac...Source: Experimental Gerontology - July 26, 2018 Category: Geriatrics Authors: Gorecka MM, Vasylenko O, Espenes J, Waterloo K, Rodríguez-Aranda C Tags: Exp Gerontol Source Type: research

Reactive oxygen species and NADPH oxidase 4 involvement in osteoarthritis. Abstract
Osteoarthritis (OA) is a degenerative chronic disease affecting>300,000 million people around the world as of 2016. Symptomatic measures exist, but there are hardly any curative treatments available. Disruption of the cartilage homeostasis in favor of catabolism leads to cartilage destruction. ROS-macromolecular-induced damage is significantly greater in OA cartilage and OA is described as low-grade chronic systemic inflammation. This review aimed to assess the critical role of cartilage ageing and oxidative stress in the OA process, focusing in particular on NADPH oxidase and especially Nox4 involveme...Source: Experimental Gerontology - July 13, 2018 Category: Geriatrics Authors: Drevet S, Gavazzi G, Grange L, Dupuy C, Lardy B Tags: Exp Gerontol Source Type: research

Aging modulates microglia phenotypes in neuroinflammation of MPTP-PD mice. Abstract
As the crucial etiological factor, aging-related microglia activation promotes the development of Parkinson's disease (PD). However, the molecular and functional changes of aged-microglia and their contribution to neurodegeneration in PD are only partially understood, which was investigated in our study. Female C57BL/6 mice were randomly divided into four groups, included young-control group, young-MPTP group, aged-control group and aged-MPTP group. Pole test and adhesive removal test were firstly performed. ELISA assay was used to detect the content of interleukin-1β (IL-1β) and tumor necrosis ...Source: Experimental Gerontology - July 12, 2018 Category: Geriatrics Authors: Yao K, Zhao YF Tags: Exp Gerontol Source Type: research

Learning new gait patterns: Age-related differences in skill acquisition and interlimb transfer. Abstract
Evidence from upper-extremity literature suggests that the normal ageing process affects an individual's ability to learn and retain a motor skill, but spares their ability to transfer the skill to the untrained, opposite limb. While this phenomenon has been well-studied in the upper-extremity, evidence in the lower-extremity is limited. Further, it is unclear to what extent age-related differences in motor learning and transfer are dependent on visual feedback of the motor task. Therefore, the purpose of this study was to examine the effects of ageing on motor learning, retention, and interlimb transfer ...Source: Experimental Gerontology - July 4, 2018 Category: Geriatrics Authors: Krishnan C, Washabaugh EP, Reid CE, Althoen MM, Ranganathan R Tags: Exp Gerontol Source Type: research

The association between decreased hand grip strength and hip fracture in older people: A systematic review. Abstract
Hip fractures are a global concern, resulting in poor outcomes and high health care costs. They mostly affect people>80 years. Hip fractures are influenced by various (modifiable) risk factors. Emerging evidence suggests hand grip strength (HGS) to be one of several useful tools to identify hip fracture risk. This is the first systematic review that aims to assess the evidence underlying the relationship between hip fracture incidence and HGS. Eleven studies were selected for this review (six case-control and five cohort studies), comprising 21,197 participants. Where reported, HGS was significantly ...Source: Experimental Gerontology - June 30, 2018 Category: Geriatrics Authors: Denk K, Lennon S, Gordon S, Jaarsma RL Tags: Exp Gerontol Source Type: research

Rate of power development of the knee extensors across the adult life span: A cross-sectional study in 1387 Flemish Caucasians. Abstract
A growing body of research in elderly populations suggests that the early phase of an explosive muscle contraction (i.e., ≤200 ms) may be more functionally relevant than peak values. However, age-related variation in early phase explosive strength have never been investigated across the full-adult life span. This cross-sectional study investigated the age-related changes in the rate of power development (RPD) and compared it to the changes in peak power (Ppeak), both in terms of magnitude and onset, across the adult life span. Age-related declines in power and determinants of muscle power were compar...Source: Experimental Gerontology - June 25, 2018 Category: Geriatrics Authors: Van Roie E, Van Driessche S, Inglis AJ, Thomis M, Delecluse C Tags: Exp Gerontol Source Type: research

Effect of exercise order of combined aerobic and resistance training on arterial stiffness in older men. Abstract
Arterial stiffness increases with advancing age, and is as an emerging biomarker in the assessment of vascular health. Some studies suggest that high-intensity resistance training increases arterial stiffness, but low- to moderate-intensity resistance training does not effect on arterial stiffening. Current evidence suggests that performing aerobic exercise after resistance training improved arterial stiffness in the young men and women. However, few studies have been conducted on the effects of the order of combined training on arterial stiffness in the elderly. The purpose of this study was to examine t...Source: Experimental Gerontology - June 25, 2018 Category: Geriatrics Authors: Shiotsu Y, Watanabe Y, Tujii S, Yanagita M Tags: Exp Gerontol Source Type: research

The relationship between muscle quality and incidence of falls in older community-dwelling women: An 18-month follow-up study. Abstract
INTRODUCTION: Important components that might mediate the relationship between aging and falls are reduced muscle strength and mass. Although muscle-related phenotypes have been linked to falls in older people, the role of muscle quality has yet to be examined.
AIM: To investigate the relationship between muscle quality and incidence of falls over an 18-month follow-up in older community-dwelling women.
METHODS: A total of 167 women (68.1 ± 6.2 years) underwent quadriceps isometric peak torque and thigh-muscle thickness assessments using isokinetic dynamometer and ultrasound, respec...Source: Experimental Gerontology - June 21, 2018 Category: Geriatrics Authors: Gadelha AB, Neri SGR, Bottaro M, Lima RM Tags: Exp Gerontol Source Type: research

The effects of donor age on organ transplants: A review and implications for aging research.es JP
Abstract
Despite the considerable amount of data available on the effect of donor age upon the outcomes of organ transplantation, these still represent an underutilized resource in aging research. In this review, we have compiled relevant studies that analyze the effect of donor age in graft and patient survival following liver, kidney, pancreas, heart, lung and cornea transplantation, with the aim of deriving insights into possible differential aging rates between the different organs. Overall, older donor age is associated with worse outcomes for all the organs studied. Nonetheless, the donor age from whic...Source: Experimental Gerontology - June 20, 2018 Category: Geriatrics Authors: Dayoub JC, Cortese F, Anžič A, Grum T, de Magalhães JP Tags: Exp Gerontol Source Type: research

Crowding of Drosophila larvae affects lifespan and other life-history traits via reduced availability of dietary yeast.e;liková M
Abstract
Conditions experienced during development have often long-lasting effects persisting into adulthood. In Drosophila, it is well-documented that larval crowding influences fitness-related traits such as body size, starvation resistance and lifespan. However, the underlying mechanism of this phenomenon is not well understood. Here, we show that the effects of increased larval density on life-history traits can be explained by decreased yeast availability in the diet during development. Yeast-poor larval diet alters various life-history traits and mimics the effects of larval crowding. In pa...Source: Experimental Gerontology - June 19, 2018 Category: Geriatrics Authors: Klepsatel P, Procházka E, Gáliková M Tags: Exp Gerontol Source Type: research

Time trends in the prevalence of cancer and non-cancer diseases among older U.S. adults: Medicare-based analysis. Abstract
Longer lifespan is accompanied by a larger number of chronic diseases among older adults. Because of a growing proportion of older adults in the U.S., this brings the problem of age-related morbidity to the forefront as a major contributor to rising medical expenditures. We evaluated 15-year time trends (from 1998 to 2013) in the prevalence of 48 acute and chronic non-cancer diseases and cancers in older U.S. adults aged 65+ and estimated the annual percentage changes of these prevalence trends using SEER-Medicare and HRS-Medicare data. We found that age-adjusted prevalence of cancers of kidney, pancreas,...Source: Experimental Gerontology - June 19, 2018 Category: Geriatrics Authors: Akushevich I, Kravchenko J, Yashkin AP, Yashin AI Tags: Exp Gerontol Source Type: research

Is increased neutrophil lymphocyte ratio remarking the inflammation in sarcopenia?A, Abiyev A
Abstract
OBJECTIVES: Increasing data suggests that chronic inflammation has an essential role on development of muscle dysfunction and progression of sarcopenia in aging population. The aim of the present study was to compare Neutrophil Lymphocyte Ratio (NLR) levels in sarcopenic and non-sarcopenic individuals and to present the correlation between NLR and other inflammatory markers.
METHODS: A total of 105 subjects with sarcopenia (male/female: 54/51, mean age 72.8 ± 7.3) and 314 subjects as non-sarcopenic (male/female: 125/189, mean age 71.44 ± 5.4) were enrolled in this cr...Source: Experimental Gerontology - June 18, 2018 Category: Geriatrics Authors: Öztürk ZA, Kul S, Türkbeyler İH, Sayıner ZA, Abiyev A Tags: Exp Gerontol Source Type: research

The effects of resveratrol and exercise on age and gender-dependent alterations of vascular functions and biomarkers. Abstract
The purpose of this study was to determine the effects of resveratrol and regular aerobic exercise on vascular functions and biomarkers related to vessel responsiveness in an age and gender-dependent manner. The study used young (3 months) and old (12 months) male and female Wistar albino rats. Resveratrol was given in the drinking water (0.05 mg/ml; approximately 7.5 mg/kg) for 6 weeks. In the exercise group, all rats performed treadmill running at 20 m/min on a 0° incline, 40 min/day, 3 times a week, for 6 weeks. Acetylcholine-induced, endothelium-dependent and sodium nitroprusside-m...Source: Experimental Gerontology - June 13, 2018 Category: Geriatrics Authors: Han S, Bal NB, Sadi G, Usanmaz SE, Orhan Uludag M, Demirel-Yilmaz E Tags: Exp Gerontol Source Type: research

The influence of ageing on the extrapineal melatonin synthetic pathway. Abstract
Ageing affects various physiological and metabolic processes in a body and a progressive accumulation of oxidative damage stands out as often used explanation. One of the most powerful scavenger of reactive oxygen species (ROS) in all organs is melatonin. A majority of melatonin supplied to the body via blood originates from the pineal gland. However, we have been interested in a locally produced melatonin. We have used 2.5- and 36-months-old Wistar rats. Tissues were collected and gene expression of AA-NAT and ASMT, the two key enzymes in a synthesis of melatonin, was determined in brain, liver, kidney, ...Source: Experimental Gerontology - June 12, 2018 Category: Geriatrics Authors: Popović B, Velimirović M, Stojković T, Brajović G, De Luka SR, Milovanović I, Stefanović S, Nikolić D, Ristić-Djurović JL, Petronijević ND, Trbovich AM Tags: Exp Gerontol Source Type: research

Effect of the head extension swallowing exercise on suprahyoid muscle activity in elderly individuals.This study showed that HESE can be a good option for improving the suprahyoid muscle and tongue strength in the elderly population. Additionally, this exercise does not require any additional equipment and has the advantage of being able to be performed anytime and anywhere. A variety of exercise options tailored according to individual characteristics may be helpful in choosing the most appropriate exercise.
PMID: 29894751 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)Source: Experimental Gerontology - June 9, 2018 Category: Geriatrics Authors: Jong-Chi OH Tags: Exp Gerontol Source Type: research