Massive Genetic Study Of North Americans Suggests They Are Even More Diverse Than We Thought

As individuals, our DNA offers insight into things like our personalities, our health and where we come from. But taken together, all those individual portraits can add up to paint a detailed history of humankind.

Image: Getty

A study published this week in Nature Communications led by the DNA testing company Ancestry.com presents exactly this kind of bird's eye view. Last month, Ancestry surpassed three million customers in its DNA databases. That's an awful lot of DNA, and now the company has set its sites on figuring out exactly what it might learn from all of it.

In the new study, Ancestry's scientists set out to build a picture of how North America's population moved across the country over the past few hundred years. Using genotype data from over 700,000 individuals who have purchased the company's DNA kits, scientists created a network of genetically-identified relationships and then used network analysis techniques to identify clusters of individuals.

Distribution of ancestral birth locations in North America associated with clusters included in the study. Image: Nature Communications

In this way, researchers were able to track, say, the particular regions in France that French Canadians came from six generations ago, where they settled in Canada three generations ago, and how they spread south to New England two generations ago.

"The analysis of the data provides incredibly valuable insights into our history and the forces that continue to shape our country, beliefs and policies," said Catherine Ball, Chief Science Officer at Ancestry and the study's lead author. "We never would have expected to see that a political boundary like the Mason Dixon Line would be a dividing line that you could see in the genetics."

Genetics have been used to track historical migration before, but this new study gives us a instead a look at recent history. Where the data is most remarkable is in its granularity -- in the ability to point not just to France but to specific regions of France, and track the migration of those groups of people over time.

Genealogical data by generation traces migration of French Canadians (magenta) to the US and origins of Cajuns/Acadians in Atlantic Canada (blue). IMAGE: Nature Communications

"It's fascinating to see this map. It really is instructive," said Eric Topol, a geneticist with Scripps who is not associated with the research. "I always thought, gosh there's a lot of Scandinavians in Minneapolis and you look at this map and well, there they are."

For Ancestry, all this means that when the company sequences your genotype, it might one day be able to tell you the specific county in Ireland your great-great-grandfather hailed from.

"We've never had a map like this of North America," Topol said. "This is a massive data set."

This kind of data presents more opportunity than just a fun dive into the annals of history. Clusters of genetically-similar individuals could help us discover more about the genes certain groups have in common, and how those commonalities might impact things like health. For instance a protective gene variant, or allele, for squamous cell lung carcinoma appeared to be 10 times more common in a cluster of Finnish immigrants. A risk allele for prostate cancer similarly had a frequency of 5.6 per cent in an African American cluster, but was extremely rare outside of it.

At a time when the US is divided along lines both racial and political, though, perhaps the most important revelation in the study is that really they are all immigrants.

"In today's polarising political climate," said Ball, "our data shows that no man or woman is an island… at least not genetically."

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