Probably wouldn't cause a major problem, but the combo could theoretically increase bleeding risk or reduce your sodium. Tylenol and Effexor XR are compatible, so I would recommend that over the ibuprofen. Warm salt water gargles three times per day and sipping warm beverages may also relieve some of the discomfort. If the tylenol alone is not effective to manage the pain, then consult with your physician as to whether they approve the ibuprofen.