Basal Body Temperature

P4R

these receptors are expressed in the hypothalamus where the GnRH pulse generator is; this allows it to block the pulse frequency and thus stop LH (preferentially) and FSH secretion, blocking fertility and menstruation

Sustained Levels

Hyperandrogenemia

this is a problem that occurs when the body receives too many androgens; androgens are converted to E2 via CYP19, and thus the pulse frequency of GnRH can be affected, blocking FSH (preferentially) and LH secretion

Primary Infertility

Secondary Infertility

Inhibin B

this acts on gonadotropes of the anterior pituitary to decrease secretion of GnRH and FSH; leads to atresia of nonselected follicles; in ovary, allows for steoidogenesis and production of growth factors

Endometrial Proliferation and Angiogenesis

Endometrial Shedding, Menstruation, and Repair

this change in the endometrium occurs in the late luteal phase due to sustained high levels of progesterone, causing decreased amounts of PR and ER-alpha receptors, no longer allowing E2 or P4 to work on it