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V-Ha-Ras Harvey Rat Sarcoma Viral Oncogene Homolog ELISA Kits (HRAS)

On www.antibodies-online.com are 17 V-Ha-Ras Harvey Rat Sarcoma Viral Oncogene Homolog (HRAS) ELISA Kits from 7 different suppliers available. Additionally we are shipping HRAS Antibodies (145) and HRAS Proteins (19) and many more products for this protein. A total of 192 HRAS products are currently listed.

More ELISA Kits for HRAS Interaction Partners

Data demonstrate that H-Ras activation is important in the activation of the specific signaling events leading to the accelerated retinal capillary cell apoptosis in hyperglycemic conditions.

Activation of H-Ras and its downstream signaling pathway in the retina and its vasculature could be under the control of superoxide, and H-Ras activation in diabetes can be prevented by inhibiting superoxide accumulation.

Analysis of HRAS mutations and their respiratory phenotype revealed that the common p.Gly12Ser mutation is more often associated with transient respiratory distress and other respiratory diagnoses.

we found that H-Ras proteins and particularly the G12V and G13D variants are significantly more flexible than their K-Ras counterparts.while most of the simulated proteins sampled the effector-interacting state 2 conformational state, G12V and G13D H-Ras adopted an open switch state 1 conformation that is defective in effector interaction

The HRAS mutation p.T58I could manifest with severe early-onset but stabilizing cardiomyopathy. The dysmorphic features are mild compared with the features of Costello syndrome. The phenotypic variability makes the diagnosis challenging, suggesting that this variant of Costello syndrome might go undiagnosed.

Age at diagnosis of follicular thyroid cancer (FTC (show FUT2 ELISA Kits)) and frequency of extrathyroidal extension have changed over four decades; prevalence of RAS mutations has decreased; HRAS/NRAS (codon 61) and TERT (show TERT ELISA Kits) (promoter) mutations may be associated with poor clinical outcomes in FTC (show FUT2 ELISA Kits), especially when two mutations coexist; this retrospective study was conducted in Seoul.

Data suggest that isoform-specific sequences in the allosteric lobes of HRAS, KRAS, and NRAS (show NRAS ELISA Kits) have an impact on biocatalysis (kinetics of GTP (show AK3 ELISA Kits) hydrolysis) and interaction with c-Raf (show RAF1 ELISA Kits) kinase, which must be due to allosteric effects on dynamics and conformational states, given the identical active sites of these isoenzymes.

HRAS Antigen Profile

Antigen Summary

This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, mental retardation, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identified for this gene.