I have severe allergic reaction to Compazine. Can I take Topamax for my migraines instead of Amitriptyline which has taken my headaches away but I'm constantly constipated and have gained 8 lbs which its making me depress. Is Compazine related or the same medication as Topamax?

Responses (2)

Hi, imiac! Compazine is a phenothiazine anti-psychotic whereas Topamax is an anticonvulsant (seizure medication with many other uses). They are not related.BTW, an 8lb weight gain is not medically significant so I wouldn;t get depressed about it.Best wishes, Wildcat

All I know is that Topamax is the best thing I have taken for a migraine. It has also helped me lose weight. Weight as also been an issue for me. Speak to you doctor first. I also eat a healthly snack with Topamax... fat free pudding, fruit, fat free peanut butter with chips, yogurt, etc.