Research

Research Overview

Research program: 1. Functional Architectures for Control of Electron Transfer at Electrodes 2. Molecular Test Bridges for Studies of Electron Tunneling. 3. Optical Screeing Methods for Library Evaluation in Microarrays 4. Probing Weak Interactions Between Bio-molecules Using a Fluorescence Balance.

Research Statement

Self-Patterning Self-Assembled Monolayers. We are investigating structure-function relationships in molecules that form self-assembled monolayers (SAMs) on surfaces. We have implemented strategies for spontaneous patterning of monolayers formed from mixtures of organic molecules that self-assemble on conductive surfaces. These self-patterning, self-assembled monolayers control assembly of single component and multi-component nanoparticle mixtures at surfaces. We are investigating the optical and magnetic properties of the patterned nanoparticle assemblies as a function of composition and geometry.

Functional Architectures for Control of Electron Transfer at Electrodes. We are preparing molecules with novel architectures that align on electrode surfaces, individually or as part of larger aggregates, and modulate electron transfer in and out of the electrode. The alignment of these 1 – 3 nm sized molecules is probed using Scanning Tunneling Microscopy (STM) and Atomic Force Microscopy (AFM). Individual molecules' conformations is modulated by interaction with the strong electric field near the STM tip. This interaction is being explored for purposes related to Molecular Electronics.

Bioactive Fluorescent Nanoparticles for Glycoprofiling. We are developing assays to distinguish malignant, benign, and healthy cells based on the identities of the carbohydrates presented on their surface. Literature precedent indicates changes in cell surface carbohydrates upon transformation from healthy to various cancerous states. These glycoprofiling assays employ panels of fluorescent nanoparticles functionalized with key lectins to quantify the carbohydrates present at cell surfaces. (In collaboration with Professor Amit Basu).