Interpretive Summary: The prevalence of overweight and obesity has increased all across the nation. Excess body fat substantially increases the risk of morbidity from many metabolic and cardiovascular diseases, including hypertension, dyslipidemia, type 2 diabetes mellitus, coronary heart disease, and stroke. Many people use dietary supplements to hopefully achieve weight loss or enhance diet and exercise-induced weight loss. Chromium picolinate (CP) and conjugated linoleic acid (CLA) are two supplements promoted for use in weight control. In this study 35 women were asked to reduce normal caloric intake by 500 kcal per day and take either a supplement containing the two weight loss products or a placebo for 12 weeks. There were no additional effects of consuming the two weight loss products after 12 weeks on weight or clinical measurements. This work should be of interest to the scientific and medical communities as well as the large numbers of people consuming supplements to lose weight.