1- CHILDREN ST. VLADIMIR HOSPITAL
2- MOSCOW REGIONAL RESEARCH CLINICAL INSTITUTE NAMED AFTER M.F.VLADIMIRSKY
3- MOSCOW STATE MEDICAL DENTIST UNIVERSITY NAMED AFTER A.I.EVDOKIMOV
4- RUSSIAN MEDICAL ACADEMY OF POST-GRADUATE EDUCATION

Introduction:

To estimate the frequency of extrarenal manifestations of aHUS in children.

Extrarenal manifestations at the beginning of the disease occur in the majority of patients with aHUS. It could be a manifestation of the disease or secondary phenomena due to volumetric overload, uremic encephalopathy, electrolyte disturbances. The high frequency of extrarenal manifestations emphasizes the need for timely start of targeted therapy.