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U.S. President Barack Obama on Monday imposed sanctions on 11 Russians and Ukrainians blamed for Russia's military incursion into Crimea, including two top aides to Russian President Vladimir Putin.

The sanctions were the most visible sign of U.S. anger at Russia's attempt to absorb the Crimea region ofsouthern Ukraine, reflecting the deepest plunge in U.S.-Russian relations since the Cold War.

The U.S. sanctions came in an executive order signed by Obama a day after Sunday's Crimea referendum aimed at allowing Russia to annex the region, a vote that the United States says was illegal and will never be recognized by Washington. Obama was to speak on the sanctions at 10:45 a.m. EDT.

Obama's order freezes any assets in the United States and bans travel into the country of seven ranking Russian government officials and four individuals identified as Crimea-based separatist leaders.

Ousted Ukrainian President Viktor Yanukovich was among those sanctioned and the United States also reached deep into Putin's inner circle by naming presidential aide Vladislav Surkov and adviser Sergei Glazyev. Russia's deputy prime minister, Dmitri Rogozin, and two state Duma deputies, Leonid Slutsky and Yelena Mizulina also were targeted.

Senior administration officials, who briefed reporters on the penalties, said they were the most comprehensive sanctions applied to Russia since the end of the Cold War.

A senior official said Obama's order clears the way for sanctions on people associated with the Russian arms industry and targets "the personal wealth of cronies" of the Russian leadership.

Putin himself was not sanctioned. A senior Obama administration official said it would have been a highly unusual step and extraordinary to target a head of state.

The administration announced plans for sanctions earlier this month but had not named the individuals until Monday.