Background*

Mr. John A. Orwin has been the Chief Executive Officer of Relypsa, Inc. since June 17, 2013 and as its President since June 2013. Mr. Orwin is a biotechnology and pharmaceutical industry veteran with nearly 25 years of experience, including senior leadership positions in many commercial oncology organizations. He served as the Chief Executive Officer of Affymax, Inc. from February 1, 2011 to May 15, 2013. Mr. Orwin served as the President and Chief Operating Officer ... at Affymax, Inc. from April 2010 to January 2011. Mr. Orwin served as Senior Vice President of Sales & Marketing - Bio Oncology of Genentech, Inc. since January 17, 2007. Mr. Orwin served as a Vice President of Bio Oncology at Genentech, Inc. until January 17, 2007. He served as a Vice President of Human EGF-Receptor (HER) Family Product Sales and Marketing at Genentech, Inc. since December 2004. Mr. Orwin was responsible for leadership and development of the HER family product portfolio, including sales and marketing activities, and the business's life cycle plans. Mr. Orwin joined Genentech from Johnson & Johnson's Ortho Biotech division, where he served as Franchise Vice President, Oncology of the Tibotec Therapeutics group. He has held Senior Marketing and Sales Positions with Schering-Plough Corporation, Rhone-Poulenc Rorer Pharmaceuticals, Sangstat Medical Corporation and Alza Pharmaceuticals. He served as the Chairman of Affymax, Inc. from June 6, 2013 to November 2014. He has been a Director of Relypsa, Inc since June 2013 and Seattle Genetics Inc. since January 13, 2014. He has been a Director of Array BioPharma, Inc. since November 6, 2012. He has been an Independent Director of NeurogesX, Inc. since November 19, 2009. He has been a Director and a Member of Emerging Companies Section Governing Board at Biotechnology Industry Organization since July 2011. He served as a Director of Affymax, Inc. from February 1, 2011 to November 2014. Mr. Orwin holds a Master of Business Administration from the Stern School of Business, New York University and a Bachelor of Arts Degree in Economics from Rutgers University.

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