Arkham is the home of Miskatonic University, which figures prominently in many of Lovecraft's works. The institution finances the expeditions in both At the Mountains of Madness (1936) and The Shadow Out of Time (1936). Walter Gilman, of "The Dreams in the Witch House" (1933), attends classes at the university. Other notable institutions in Arkham are the Arkham Historical Society and the Arkham Sanitarium. It is said in "Herbert West—Reanimator" that the town was devastated by a typhoid outbreak in 1905.

Arkham's main newspaper is the Arkham Advertiser, which has a circulation that reaches as far as Dunwich. In the 1880s, its newspaper is called the Arkham Gazette.

Arkham’s most notable characteristics are its gambrel roofs and the dark legends that have surrounded the city for centuries. The disappearance of children (presumably murdered in ritual sacrifices) at May Eve and other "bad doings" are accepted as a part of life for the poorer citizens of the city.