Motorola ceased development of the 68000 series architecture in 1994 replacing it with the development of the PowerPC architecture, which they developed in conjunction with IBM and Apple Computer as part of the AIM alliance.

Additionally, and perhaps most significantly, the first several versions of Adobe's PostScript interpreters were 68000-based. The 68000 in the Apple LaserWriter and LaserWriter Plus was clocked faster than the version used in Macintosh computers at the time. A fast 68030 in later PostScript interpreters, including the standard resolution LaserWriter IIntx, IIf and IIg (also 300 dpi), the higher resolution LaserWriter Pro 600 series (usually 600 dpi, but limited to 300 dpi with minimum RAM installed) and the very high resolution Linotronic imagesetters, the 200PS (1500+ dpi) and 300PS (2500+ dpi). Thereafter, Adobe generally preferred a RISC for its processor, as its competitors, with their PostScript clones, had already gone with RISCs, often an AMD 29000-series. The early 68000-based Adobe PostScript interpreters and their hardware were named for cold war U.S. rockets and missiles: Atlas, Redstone, etc.

Today, these systems are either end-of-line (in the case of the Atari), or are using different processors (in the case of Macintosh, Amiga, Sun, and SGI). Since these platforms had their marketshare peak in the 1980s, their original manufacturers are unlikely to support an operating system for this hardware or are even out of business. However, the GNU/Linux, NetBSD and OpenBSD operating systems still include support for 68000 processors.

The 68000 processors were also used in the Sega Mega Drive/Sega Genesis and SNKNeo Geo consoles as the main CPU. Other consoles such as the Sega Saturn used the 68000 for audio processing and other I/O tasks, while the Atari Jaguar included a 68000 which was intended for basic system control and input processing, but due to the Jaguar's unusual assortment of heterogeneous processors was also frequently used for running game logic. Many arcade boards also used 68000 processors including boards from Capcom, SNK, and Sega.

Microcontrollers derived from the 68000 family have been used in a huge variety of applications. For example, CPU32 and ColdFire microcontrollers have been manufactured in the millions as automotive engine controllers.

People who are familiar with the PDP-11 or VAX usually feel comfortable with the 68000. With the exception of the split of general purpose registers into specialized data and address registers, the 68000 architecture is in many ways a 32-bit PDP-11.

The instruction set was much more "orthogonal" than those of many processors that came before (e.g., 8080) and after (e.g., x86). That is, it was typically possible to combine operations freely with operands, rather than being restricted to using certain addressing modes with certain instructions. This property made programming relatively easy for humans, and also made it easier to write code generators for compilers.

The 68000 instruction set can be divided in the following broad categories:

There was no 68050, though at one point it was a project within Motorola. Odd-numbered releases had always been reactions to issues raised within the previous even numbered part; hence, it was generally expected that the 68050 would have reduced the 68040's power consumption (and thus heat dissipation), improved exception handling in the FPU, used a smaller feature size and optimized the microcode in line with program use of instructions. Many of these optimizations were included with the 68060 and were part of its design goals. For any number of reasons, likely that the 68060 was in development, that the Intel 80486 wasn't progressing as quickly as Motorola assumed it would, and that 68060 was a demanding project, the 68050 was cancelled early in development.

There is also no revision of the 68060, as Motorola was in the process of shifting away from the 68000 and 88k processor lines into its new PowerPC business, so the 68070 was never developed. Had it been, it would have been a revised 68060, likely with a superior FPU (pipelining was widely speculated upon on Usenet).

Motorola mainly used even numbers for major revisions to the CPU core such as 68000, 68020, 68040 and 68060. The 68010 was a revised version of the 68000 with minor modifications to the core, and likewise the 68030 was a revised 68020 with some more powerful features, none of them significant enough to classify as a major upgrade to the core.

There was a CPU with the 68070 designation, which was a licensed and somewhat slower version of the 16/32-bit 68000 with a basic DMA controller, I²C host and an on-chip serial port. This 68070 was used as the main CPU in the PhilipsCD-i. This CPU was, however, produced by Philips and not officially part of Motorola's 680x0 lineup.

After the mainline 68000 processors' demise, the 68000 family has been used to some extent in microcontroller/embedded microprocessor versions. These chips include the ones listed under "other" above, i.e. the CPU32 (aka 68330), the ColdFire, the QUICC and the DragonBall.

During the 1980s and early 1990s, when the 68000 was widely used in desktop computers, it mainly competed against Intel's x86 architecture, which to this day — other than a small minority of Transmeta VLIW processors — remains the only architecture used in IBM Compatible PCs. Generation 1 68000 CPUs primarily competed against the 16-bit8086/8088 and 80286. Generation 2 competed against the 80386 (the first 32-bit x86 processor), and generation 3 against the 80486. The fourth generation competed with the P5Pentium line, but it was not nearly as widely used as its predecessors, since much of the old 68000 marketplace was either defunct or nearly so (as was the case with Atari and NeXT), or converting to newer architectures (PowerPC for the Macintosh and Amiga, SPARC for Sun, and MIPS for SGI).

There are dozens of processor architectures that are currently successful in embedded systems. Some are microcontrollers which are much simpler, smaller, and cheaper than the 68000, while others are relatively sophisticated and capable of running complex software. Embedded versions of the 68000 often compete with processors derived from the PowerPC, ARM, MIPS, and SuperH architectures, among others.