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A lack of donor organs continues to plague the transplant community. Retransplantation in this setting can be controversial and requires cautious selection of recipients. This study reviewed the UNOS database for factors which could potentially serve as relative contraindications to heart retransplantation. In contrast to other studies, acute need for retransplantation, primary graft failure and graft vasculopathy were not predictors of graft failure following retransplantation after multivariate analysis