The Falcons (4-0) are off to their best start since 2004, when they reached the NFC championship game. Despite taking a career-high seven sacks, Matt Ryan threw three touchdown passes for Atlanta. Bryant added three field goals.

The Panthers (1-3) nearly clinched it on Cam Newton's run with just over a minute remaining, but he fumbled the ball while trying to dive for the necessary yardage. Carolina recovered and wound up punting, downing the ball at the Atlanta 1. But Ryan immediately got the Falcons out of the hole, throwing a 59-yard pass to Roddy White.

Arian Foster had a touchdown run for the Texans (4-0), who are off to the best start in club history.

Titans quarterback Jake Locker left in the first quarter and did not return after hurting his left, non-throwing shoulder on a hit by Glover Quin.

Matt Hasselbeck threw two touchdown passes in relief of Locker for the Titans (1-3). Chris Johnson carried 25 times for 141 yards, more than tripling his rushing total through the first three games.

49ERS 34, JETS 0

EAST RUTHERFORD, N.J. (AP) -- Carlos Rogers returned a fumble 51 yards for a touchdown, and San Francisco ran for more than 200 yards.

Frank Gore, Kendall Hunter and backup quarterback Colin Kaepernick -- on a wildcat-style option -- all ran for scores as the 49ers (3-1) bounced back from a loss at Minnesota. Rather than head back to the West Coast, coach Jim Harbaugh chose to have his team stay in eastern Ohio -- and it apparently helped.

The Jets (2-2) lost top wide receiver Santonio Holmes to what appeared to be a serious foot injury. It was the first time New York was shut out since losing 9-0 to Green Bay in 2010, and the Jets' biggest shutout home loss since falling 37-0 to Buffalo in 1989.

VIKINGS 20, LIONS 13

DETROIT (AP) -- Percy Harvin returned the opening kickoff 105 yards for a touchdown and Marcus Sherels scored on a punt return early in the third for Minnesota.

Minnesota (3-1), in first place in the NFC North, matched the number of wins it had last season. The Vikings also snapped an 11-game losing streak in the division.

The Lions (1-3) have lost three straight.

They are the first team since at least 1940 to give up a kickoff and a punt return for TDs in consecutive games, according to STATS LLC. They gave up scores on a kickoff and punt in last week's 44-41 loss in overtime at Tennessee.

RAMS 19, SEAHAWKS

ST. LOUIS (AP) -- Rookie Greg Zuerlein kicked four field goals, including a 58-yarder and a club record 60-yarder, and the Rams also used a fake field goal to score their only TD of the game.

The Rams 2-2) went ahead 10-7 late in the first half when a fake field goal attempt turned into a 2-yard touchdown pass from punter Johnny Hekker to Danny Amendola.

The Seahawks (2-2) lost six days after beating Green Bay when a botched call by replacement officials on the final play gave them the winning touchdown. Regular officials were back this weekend.

Marshawn Lynch led Seattle with 118 yards on 20 carries, including an 18-yard score on the game's first possession.

The Rams intercepted Russell Wilson three times, with Bradley Fletcher clinching it with a pick at the Rams 25 with a minute to go.

Brady finished 22 of 36 for 340 yards and three scores, and also scored on a 4-yard run in helping the Patriots (2-2) avoid their first three-game losing streak in 10 years. Stevan Ridley scored two touchdowns rushing. New England scored 35 straight points and finished with 580 total yards in overcoming a 21-7 third-quarter deficit.

The Patriots forced six turnovers, including four interceptions of Ryan Fitzpatrick passes, and three sacks.

Fitzpatrick finished 22 of 39 for 350 yards and four touchdowns, including two to tight end Scott Chandler.

The Bills (2-2) dropped to 1-17 in their last 18 games against New England.

CHARGERS 37, CHIEFS 20

KANSAS CITY, Mo. (AP) -- Philip Rivers threw for 209 yards and two touchdowns, and San Diego capitalized on six turnovers.

Five of the Chiefs' turnovers came in the first half, when San Diego (3-1) raced to a 27-6 lead.

Matt Cassel threw for 251 yards and two touchdowns for Kansas City (1-3), but he also had three first-half interceptions. Jamaal Charles, who followed his big game last week at New Orleans with touchdowns rushing and receiving, fumbled twice.