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Do men want new options? We get letters every day from men around the world asking: “How can I get access to these new contraceptives?”

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Do men want new options? Over 40% of US couples rely on the currently available male contraceptives Source: CDC (2006) Health, United States

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Surveys say “Yes” In 12 countries, the majority of men would use a new hormonal male contraceptive –50% of US men Men are motivated by desire to share family planning responsibility & have direct control over their fertility Sources: Martin (2000) Human Reproduction 15(3): 637-45. Heinemann (2005) Human Reproduction 20(2): 549-56. MCC (2007) Male Contraception Quarterly 3: 1-4.

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Reversal proven in primates after 7 months of use, all had normal sperm count within 1 month of reversal Another 20 minute out-patient procedure required to remove, as opposed to 3-4 hours of microsurgery for vasovasostomy Not yet tested in men Source: Zaneveld (1999) In Rajalakshmi & Griffin (eds.), Male Contraception: Present and Future, p. 293. IVD – How is it reversed?

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MHCs – What are they? Supra-physiological dose of testosterone suppresses testicular production of T and halts spermatogenesis May include a progestin for faster, more complete suppression No orally available T; delivery via implants, depot injections, transdermal gels and patches

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T-only formulations are more effective for Asian men MHCs – Formulations

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Similar to side effects experienced by women on hormonal contraceptives Mild weight gain, increase in lean muscle mass, acne Drop in HDL cholesterol level with some androgens No prostate over-stimulation observed in studies up to 18 months MHCs – Side effects