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Human TSPY-Like 2 (TSPYL2) interaction partners

homozygous Asp3779Asn and a hemizygous Ile262Met mutations in the LRP2 (show LRP2 ELISA Kits) and TSPYL2 genes, respectively, in a Pakistani family with two boys affected with mild nonsyndromic intellectual disability

The oncogenic events leading to an ectopic activation of TSPY and/or inactivating mutation/epigenetic silencing of TSPX could collectively contribute to the sexual dimorphism(s) in HCC (show FAM126A ELISA Kits) and related liver cancers in male-biased manners.

TSPYL2 serves a biological role in maintaining the G1 checkpoint under stress condition.

DENTT may play a role in development of the endocrine tissues, nervous system, lung, oocytes, and thecal cells, and testis [DENTT]

DENTT may play multiple roles in modulating transcriptional responses suggesting new roles for the TTSN superfamily during embryogenesis and differentiation.

Mice treated with hypertonic saline expressed higher CINAP protein levels in the PVN, supporting a role of CINAP in neural response in vivo.

TSPY-Like 2 (TSPYL2) Antigen Profile

Antigen Summary

This gene encodes a member of the testis-specific protein Y-encoded, TSPY-like/SET/nucleosome assembly protein-1 superfamily. The encoded protein is localized to the nucleolus where it functions in chromatin remodeling and as an inhibitor of cell-cycle progression. This protein may play a role in the suppression of tumor growth.