The purpose of this study is to investigate the impact of exchange rate misalignment on inflation persistence. For this purpose, Vector Auto Regression method and Markov Switching model is used for quarterly data during 1989:4 -2014:3. The results show that, the impact of liquidity growth and exchange rate misalignment on inflation persistence is positive. On the other hand, GDP growth has a negative effect on inflation persistence. By Markov Switching model the nonlinear relationship between variables was investigated; based on Markov Switching model, quarterly inflationary environment (inflation regime) were extracted for economy of Iran, and the results show three different regimes for quarterly inflation. Markov model findings are consistent with VAR model findings. Results also show that, the impact of exchange rate misalignment on stable inflation regime is positive and the impact of exchange rate misalignment on unstable inflation regime is negative.