Noun: A mysterious and presumably potent drug named for its close association with American actor Charlie Sheen, its most famous user. Over-consumption may lead to wild, drug-fueled benders, failed marriages, and an alarming amount of time spent in the company of prostitutes and other questionable personalities.

Inexplicably, Charlie Sheen (the drug) does not show up on drug tests.

May also refer to a large joint packed with a wide assortment of drugs, including but not limited to: marijuana, opium, Ecstasy, heroin, cocaine, amphetamines, etc. A close relative to the Jeffrey.

"Yeah, I am on a drug - it's called Charlie Sheen." - Charlie Sheen

"I have one speed. I have one gear. Go!" - Charlie Sheen, under the influence of Charlie Sheen

Throwing a 36-hour house party with a pornstar, in which you watch 3-hours worth of porn, only to critique it and do a suit-case of cocaine, collapsing and being rushed to a hospital. You then spend the next couple of days of your life in rehab trying to put the pieces back together.

Anthony: Yo what happened bro? I haven't seen you in a month! Last time I saw you, you locked yourself in a room with a porn star carrying a suit case.

Henry: Yeah man, I still don't remember what happened! That's what I get for pulling off a Charlie Sheen...