BIG Data Center
in Beijing Institute of Genomics

BIG Search

BIG Search is a scalable text search engine built based on ElasticSearch (a highly scalable open-source
full-text search and analytics engine based on Apache Lucene). It features cross-domain search and facilitates
users to gain access to a wide range of biomedical data, not only from BIGD databases but also partner databases
throughout the world.

Title: The candidate gene analysis for human facial morphology in Eurasian population

Description: To Explore the genetic mechanisms of human facial morphology, Several variants for about 700 Uyghur individuals were genotyped on Illumina Infinium Global Screening Array 650K. At the same time, various of facial phenotypes were derived from all sample.

Description: Mucosal melanomas (MMs) are one of the deadliest sub-types of melanoma and has a greater incidence in East-Asian population. Few therapeutic approaches have been shown to improve outcomes specifically in patients with MM. To understand the genetic underlying of MMs, our project has gained a relatively large set of MM samples for whole-genome sequencing (WGS). We hope our study could provide insights into the genomic aberrations associated with MM and demonstrate how these insights can inform triage of patients for effective precision cancer treatments.

Description: Benzene as a known human cancinogen can directly induce genetic lesion. However, the effect of benzene metabolites on DNA repair has been rarely studied, and the biological mechanisms of that was also unclear. To explore the impact of benzene metabolite on DNA repair, we used human osteosarcoma U2OS cells containing stably integrated repair substrate for homologous repair to be treated with benzene metabolite hydroquinone.

Description: This project aims to illustrate the effects of cold and warm ischemia time on human pancreatic tissue.Sequencing results illustrate the effects of different ischemic times on tissue genes.