Conflict of interest: Alessandro Assandri is the CEO of the Contract Research Organisation Cross Research S.A., Fabrizio Nannipieri is the Director of Clinical Research of Abiogen Pharma S.p.A., and Sergio Rosini is Chief of Research and Development Division of Abiogen Pharma S.p.A. Peter Anderer, Bernd Saletu, Michael Wolzt, Svetlana Culic, and Gerda M. Saletu-Zyhlarz have no financial affiliation or other relationship relevant to the subject matter of this article.