Nav1.8 is a tetrodotoxin-resistant (TTX-R) sodium channel with high activation threshold and slow inactivating kinetics that is highly expressed in small-diameter sensory neurons and has been implicated in signaling various types of pain. A-803467 is a sodium channel blocker with high-affinity and selectivity for inhibiting human Nav1.8 sodium channels (IC50 = 8 nM when stimulated at half-maximal inactivation and IC50 = 79 nM at a resting state). This compound is unusual in that it blocks hNav1.8 at negative resting membrane potentials (many small molecule sodium channel blockers show a reduced affinity for the resting state) and does not demonstrate significant frequency-dependent block during a 10 Hz pulse train. A-803467 dose-dependently reduces behavioral responses in a variety of neuropathic and inflammatory pain models.

Product No.

KT00017

Product Name

A-803467

Synonyms

Formal Name

5-?(4-?chlorophenyl)-?N-?(3,?5-?dimethoxyphenyl)-?2-?furancarboxamide

CAS Number

944261-79-4

Molecular Formula

C19H16ClNO4

Formula Weight

357.8

Formulation

A crystalline solid

Purity

98%min

Stability

1 year

Storage

-20℃

Shipping

USD45 for Europe and USA. No shipping charge once amount reach USD500.