Microsoft Office 2011 14.2.2 This update fixes critical issues and also helps to improve security. It includes fixes for vulnerabilities that an attacker can use to overwrite the contents of your computer's memory with malicious code.

Adobe issued security bulletins for the most recent bunch of "critical" vulnerabilities:

Security bulletin APSB12-13 Adobe released a security update for Adobe Shockwave Player 11.6.4.634 and earlier versions for Windows and Macintosh. This update addresses vulnerabilities that could allow an attacker who successfully exploits these vulnerabilities to run malicious code on the affected system. Adobe recommends users of Adobe Shockwave Player 11.6.4.634 and earlier for Windows and Macintosh update to Adobe Shockwave Player 11.6.5.635 ...

Security bulletin APSB12-11 Adobe released a security upgrade for Adobe Photoshop CS5.5 and earlier for Windows and Macintosh. This upgrade addresses vulnerabilities that could allow an attacker who successfully exploits these vulnerabilities to take control of the affected system. Adobe has released Adobe Photoshop CS6, which addresses these vulnerabilities. ...

Security bulletin APSB12-12 Adobe released a security upgrade for Adobe Flash Professional CS5.5 (11.5.1.349) and earlier for Windows and Macintosh. This upgrade addresses a vulnerability that could allow an attacker who successfully exploits this vulnerability to take control of the affected system. Adobe has released Adobe Flash Professional CS6, which addresses this vulnerability. ...

Security bulletin APSB12-10 Adobe released a security upgrade for Adobe Illustrator CS5.5 and earlier for Windows and Macintosh. This upgrade addresses vulnerabilities that could allow an attacker who successfully exploits these vulnerabilities to take control of the affected system. Adobe has released Adobe Illustrator CS6, which addresses these vulnerabilities. ...