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HerbalGram 100 celebrates 100 issues of HerbalGram with a reflection on earlier issues by Steven Foster; history and highlights of the American Botanical Council; the story of ABC's home, the Case Mill Homestead; as well as articles on a preliminary analysis of the Voynich Manuscript; assessment of systematic reviews of adverse effects of herbal medicines; berberine and lowered blood lipids; Zembrin sceletium extract's anti-anxiety activity; American ginseng's safety and effectiveness for reducing cancer-related fatigue; pelargonium extract's safety and effectiveness as adjunct in managing chronic obstructive pulmonary disease; pomegranate (Punica granatum) profile; and more.