Social polarization is perhaps most evident within the worlds large cities where we can easily observe stark contrasts between wealth and poverty. A world city theoretical perspective has emerged that associates large cities importance in a global network of cities to the degree of internal polarization within these cities. The research reported here locates 57 large US cities within this world city hierarchy and then empirically examines the hypothesized positive association between global centrality and social polarization using a multivariate, cross-city analysis. The findings are mixed, with some evidence that global centrality increases income polarization, but only in the context of higher levels of immigration. There is no evidence that a citys centrality affects occupational polarization. We conclude by suggesting implications for the world city literature and future research.