MEDELLIN, Colombia -- Venus Williams defeated her sister Serena Williams 6-4, 7-6 (5) in an exhibition match in Colombia, the first match for both siblings since the U.S. Open in September.

The match late Wednesday was the first for Venus since she pulled out of the U.S. Open after the first round because of an immune system disease. Serena's last match was her loss to Samantha Stosur in the U.S. Open final.

Serena leads Venus 13-10 in competitive head-to-head matches. The exhibition match is not being counted in that list.

The Williams sisters will play Italians Francesca Schiavone and Flavia Pennetta in another exhibition in Milan on Dec. 3.

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US tennis player Venus Williams returns a ball to her sister Serena Williams during an exhibition match at La Macarena bullring in Medellin on November 23, 2011. Venus won 6-4, 7-6 (7/4). AFP PHOTO/Raul ARBOLEDA (Photo credit should read RAUL ARBOLEDA/AFP/Getty Images)

US tennis player Venus Williams serves to her sister Serena Williams during an exhibition match at La Macarena bullring in Medellin on November 23, 2011. Venus won 6-4, 7-6 (7/4). AFP PHOTO/Raul ARBOLEDA (Photo credit should read RAUL ARBOLEDA/AFP/Getty Images)

US tennis player Venus Williams returns a ball to her sister Serena Williams during an exhibition match at La Macarena bullring in Medellin on November 23, 2011. Venus won 6-4, 7-6 (7/4). AFP PHOTO/Raul ARBOLEDA (Photo credit should read RAUL ARBOLEDA/AFP/Getty Images)

US tennis player Serena Williams returns a ball to her sister Venus Williams during an exhibition match at La Macarena bullring in Medellin on November 23, 2011. Venus won 6-4, 7-6 (7/4). AFP PHOTO/Raul ARBOLEDA (Photo credit should read RAUL ARBOLEDA/AFP/Getty Images)

US tennis player Serena Williams (R) stands by to return the ball during a training session in Medellin, Antioquia department, Colombia on November 23, 2011. Venus will make her comeback in an exhibition match against her sister Serena in Medellin, two months after pulling out of the U.S. Open because of an immune system disease. AFP PHOTO/Raul ARBOLEDA (Photo credit should read RAUL ARBOLEDA/AFP/Getty Images)

US tennis player Serena Williams holds her racket during a training session in Medellin, Antioquia department, Colombia on November 23, 2011. Venus will make her comeback in an exhibition match against her sister Serena in Medellin, two months after pulling out of the U.S. Open because of an immune system disease. AFP PHOTO/Raul ARBOLEDA (Photo credit should read RAUL ARBOLEDA/AFP/Getty Images)

US tennis player Serena Williams tries to return the ball during a training session in Medellin, Antioquia department, Colombia on November 23, 2011. Venus will make her comeback in an exhibition match against her sister Serena in Medellin, two months after pulling out of the U.S. Open because of an immune system disease. AFP PHOTO/Raul ARBOLEDA (Photo credit should read RAUL ARBOLEDA/AFP/Getty Images)