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Two are out indefinitely (Michael Crabtree and Mario Manningham), one now works in Nashville (Delanie Walker) and another is a future Hall of Famer who is currently unemployed (Randy Moss).

Of Colin Kaepernick’s top five targets in 2012, four don’t figure to step on the field when the 49ers host the Packers in Week 1. The exception is tight end Vernon Davis, who had 39 targets in Kaepernick’s 10 starts last year.

The other potential pass-catchers in the season opener are Anquan Boldin, Kyle Williams, A.J. Jenkins, Vance McDonald, Quinton Patton, Chad Hall and Ricardo Lockette, a group that was targeted with five passes in Kaepernick’s starts in 2012.

Obviously, Kaepernick and the new faces will spend the offseason enrolled in Chemistry 101, a class in which Boldin is evidently earning an “A-plus-plus,” to borrow a Harbaugh-ism. I’m not in town and did not attend Tuesday’s open practice, but it appears Kaepernick has already reached an effective I’ll-throw-it-in-the-area-and-you-get-it understanding with the three-time Pro Bowler.

Boldin and Davis are the most logical targets to catch the passes that otherwise would have thrown to Crabtree, who won’t be back until late November, at the earliest. As the numbers illustrate below, Kaepernick threw it often (and wildly successfully) to Crabtree last year.

In the playoffs, however, he also discovered Davis, who was mostly a rumor in Kaepernick’s seven regular-season starts. The 49ers, of course, hope the duo maintains that connection in 2013. They also hope the addition of Boldin, a healthy Williams and Manningham and the emergence of a young receiver can help offset the loss of Crabtree.

Here’s a look at Kaepernick’s numbers in his 10 starts last year when targeting specific pass-catchers (10-target minimum):

TO WR MICHAEL CRABTREE

Kaepernick: 61 of 94, 880 yards, 8 TD, 0 INT

QB rating: 123.5

Note: Crabtree was targeted with just 17 fewer passes than the combined total of Kaepernick’s next three favorite targets: Davis, Moss and Walker.

*********************************************

TO TE VERNON DAVIS

Kaepernick: 24 of 39, 398 yards, 2 TD, 1 INT

QB rating: 102.3

Note: In three playoff games, Kaepernick completed 12 of 19 passes for 254 yards with one touchdown and one interception when targeting Davis.

*********************************************

TO WR RANDY MOSS

Kaepernick: 20 of 39, 292 yards, 1 TD, 3 INT

QB rating: 52.5

Note: Kaepernick threw five interceptions in his 10 starts: three were intended for Moss, one was intended for Davis and the other was thrown in the direction of Williams.

*********************************************

TO TE DELANIE WALKER

Kaepernick: 19 of 33, 335 yards, 2 TD, 0 INT

QB rating: 112.6

Note: These impressive numbers could have been even better: According to Pro Football Focus, five of those 14 incompletions were drops.

*********************************************

TO WR MARIO MANNINGHAM

Kaepernick: 13 of 17, 151 yards, 0 TD, 0 INT

QB rating: 102.8

Note: Kaepernick completed 12 of his first 13 passes thrown to Manningham.

*********************************************

TO RB FRANK GORE

Kaepernick: 11 of 14, 143 yards, 1 TD, 0 INT

QB rating: 133.0

Note: Kaepernick’s longest completion of the postseason was a 45-yarder to Gore in the divisional playoffs against Green Bay.