Collins (R-Maine) was a pivotal Republican swing vote in Kavanaugh's confirmation, while Hirono was one of the most forceful voices opposing the judge.

Hirono railed against Kavanaugh over the sexual misconduct allegations as well as his stance on issues such as abortion and immigration rights. She was one of four Democratic senators to walk out of a Judiciary Committee hearing in protest of a planned vote.

Graham during the Fox News segment lauded Collins for voting "yes" on Kavanaugh, saying she did not want to "legitimize" the bruising nomination process.

"If she legitimized this process, God help the next person to be nominated to the Supreme Court," Graham said.

Hannity poked fun at Graham, interrupting him at one point to echo remarks from Hirono, who said in recent weeks that men should "shut up and step up for once."