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Description of substance: Red or yellow, oily liquid with an amine-like odor.

LEL: Unknown

Original (SCP) IDLH: 50 mg/m3

Basis for original (SCP) IDLH: Because no data on acute inhalation toxicity are available for anisidine (o-, p-isomers), the chosen IDLH is based on chronic data. ACGIH [1971] reported that mice survived exposures to 10 to 30 mg/m3 for 2 hours/day, 6 days/week for 1 month; a decrease in the excitability of nerves was noted [Zaeva and Fedorova 1962]. Because mice survived 30 mg/m3, 2 hours/day, 6 days/week for 1 month, a worker should be able to escape from 50 mg/m3 without injury or irreversible health effects.

Short-term exposure guidelines: None developed

ACUTE TOXICITY DATA

Lethal dose data:

Species

Reference

Route

LD50(mg/kg)

LDLo(mg/kg)

Adjusted LD

Derived Value

Rat

IARC 1982

oral

2,000

-----

14,000 mg/m3

1,400 mg/m3

Mouse

IARC 1982

oral

1,400

-----

9,800 mg/m3

980 mg/m3

Rabbit

IARC 1982

oral

870

-----

6,090 mg/m3

609 mg/m3

Other animal data: Mice have survived exposures to concentrations of 10 to 30 mg/m3 for 2 hours/day, 6 days/week for 1 month with only a decrease in the excitability of nerves noted [Zaeva and Fedorova 1962].

Human data: None relevant for use in determining the revised IDLH.

Revised IDLH: 50 mg/m3 [Unchanged]

Basis for revised IDLH: Based on subchronic inhalation toxicity data in animals [Zaeva and Fedorova 1962], the original IDLH for o-anisidine (50 mg/m3) is not being revised at this time. [Note: NIOSH recommends as part of its carcinogen policy that the "most protective" respirators be worn for o-anisidine at concentrations above 0.5 mg/m3.]