Textmining

Fusion

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Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:query proteins and first shell of interactors

white nodes:second shell of interactors

Node Content

empty nodes:proteins of unknown 3D structure

filled nodes:some 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

HMPREF9018_0384

MATE efflux family protein (477 aa)

Predicted Functional Partners:

HMPREF9018_0720

MATE efflux family protein (454 aa)

0.621

HMPREF9018_0989

PhoH family protein (321 aa)

0.589

HMPREF9018_1603

Acyltransferase (1194 aa)

0.559

HMPREF9018_0690

Acyltransferase (255 aa)

0.559

HMPREF9018_0577

Acyltransferase (181 aa)

0.559

HMPREF9018_0912

Single-stranded DNA-binding protein (137 aa)

0.486

HMPREF9018_0385

Peptidyl-prolyl cis-trans isomerase (210 aa)

0.483

HMPREF9018_1669

Uncharacterized protein (790 aa)

0.479

rbfA

Ribosome-binding factor A ; Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5’-terminal helix region of 16S rRNA (113 aa)

a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1

node2

node1 accession

node2 accession

node1 annotation

node2 annotation

score

HMPREF9018_0384

HMPREF9018_0385

HMPREF9018_0384

HMPREF9018_0385

MATE efflux family protein

Peptidyl-prolyl cis-trans isomerase

0.483

HMPREF9018_0384

HMPREF9018_0577

HMPREF9018_0384

HMPREF9018_0577

MATE efflux family protein

Acyltransferase

0.559

HMPREF9018_0384

HMPREF9018_0690

HMPREF9018_0384

HMPREF9018_0690

MATE efflux family protein

Acyltransferase

0.559

HMPREF9018_0384

HMPREF9018_0720

HMPREF9018_0384

HMPREF9018_0720

MATE efflux family protein

MATE efflux family protein

0.621

HMPREF9018_0384

HMPREF9018_0912

HMPREF9018_0384

HMPREF9018_0912

MATE efflux family protein

Single-stranded DNA-binding protein

0.486

HMPREF9018_0384

HMPREF9018_0989

HMPREF9018_0384

HMPREF9018_0989

MATE efflux family protein

PhoH family protein

0.589

HMPREF9018_0384

HMPREF9018_1139

HMPREF9018_0384

HMPREF9018_1139

MATE efflux family protein

DHHA1 domain protein

0.403

HMPREF9018_0384

HMPREF9018_1603

HMPREF9018_0384

HMPREF9018_1603

MATE efflux family protein

Acyltransferase

0.559

HMPREF9018_0384

HMPREF9018_1669

HMPREF9018_0384

HMPREF9018_1669

MATE efflux family protein

Uncharacterized protein

0.479

HMPREF9018_0384

rbfA

HMPREF9018_0384

HMPREF9018_1681

MATE efflux family protein

Ribosome-binding factor A ; Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5’-terminal helix region of 16S rRNA

0.403

HMPREF9018_0385

HMPREF9018_0384

HMPREF9018_0385

HMPREF9018_0384

Peptidyl-prolyl cis-trans isomerase

MATE efflux family protein

0.483

HMPREF9018_0577

HMPREF9018_0384

HMPREF9018_0577

HMPREF9018_0384

Acyltransferase

MATE efflux family protein

0.559

HMPREF9018_0577

HMPREF9018_0720

HMPREF9018_0577

HMPREF9018_0720

Acyltransferase

MATE efflux family protein

0.559

HMPREF9018_0690

HMPREF9018_0384

HMPREF9018_0690

HMPREF9018_0384

Acyltransferase

MATE efflux family protein

0.559

HMPREF9018_0690

HMPREF9018_0720

HMPREF9018_0690

HMPREF9018_0720

Acyltransferase

MATE efflux family protein

0.559

HMPREF9018_0720

HMPREF9018_0384

HMPREF9018_0720

HMPREF9018_0384

MATE efflux family protein

MATE efflux family protein

0.621

HMPREF9018_0720

HMPREF9018_0577

HMPREF9018_0720

HMPREF9018_0577

MATE efflux family protein

Acyltransferase

0.559

HMPREF9018_0720

HMPREF9018_0690

HMPREF9018_0720

HMPREF9018_0690

MATE efflux family protein

Acyltransferase

0.559

HMPREF9018_0720

HMPREF9018_0912

HMPREF9018_0720

HMPREF9018_0912

MATE efflux family protein

Single-stranded DNA-binding protein

0.486

HMPREF9018_0720

HMPREF9018_0989

HMPREF9018_0720

HMPREF9018_0989

MATE efflux family protein

PhoH family protein

0.589

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Network Stats

Network Stats analysis is still ongoing, please wait ...

Functional enrichments in your networkNote: some enrichments may be expected here (why?)

Enrichment analysis is still ongoing, please wait ...

Statistical background

For the above enrichment analysis, the following statistical background is assumed: