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Cognex Q&A

COGNEX SUMMARY

Cognex

Cognex® (tacrine hydrochloride) is a reversible cholinesterase inhibitor, known chemically as 1,2,3,4-tetrahydro-9-acridinamine monohydrochloride monohydrate. Tacrine hydrochloride is commonly referred to in the clinical and pharmacological literature as THA.

Cognex® (tacrine hydrochloride capsules) is indicated for the treatment of mild to moderate dementia of the Alzheimer's type.

Evidence of Cognex®'s effectiveness in the treatment of dementia of the Alzheimer's type derives from results of two adequate and well-controlled clinical investigations that compared tacrine and placebo on both a performance based measure of cognition and a clinician's global assessment of change. (See CLINICAL PHARMACOLOGY Section: Clinical Trial Data).

Plasma tacrine concentrations are significantly increased by concomitant hormone replacement therapy. [1999.12]BACKGROUND: In vitro results suggest that the synthetic hormones used in postmenopausal hormone replacement therapy (HRT) may be significant inhibitors of oxidative drug metabolism. Moreover, HRT has been reported to enhance response to tacrine in postmenopausal patients with Alzheimer's disease, but the mechanism of this interaction remains unclear. OBJECTIVE: To examine the effect of HRT with 2 mg estradiol valerate and 0.25 mg levonorgestrel once daily on the pharmacokinetics of tacrine... CONCLUSIONS: HRT with estradiol and levonorgestrel significantly increased plasma tacrine concentrations. This interaction between tacrine and HRT involves reduced metabolic conversion of tacrine to its main metabolite 1-hydroxytacrine by CYP1A2 during the first-pass phase. The interaction may be clinically important with regard to both enhanced efficacy and increased likelihood of concentration-dependent adverse effects of tacrine in the long-term treatment of patients with Alzheimer's disease. Accordingly, smaller doses of tacrine may be appropriate when coadministered with HRT.

Clinical Trials Related to Cognex (Tacrine)

Tacrine Effects on Cocaine Self-Administration and Pharmacokinetics [Not yet recruiting]
No medications are currently available for treatment of psychostimulant addiction, a
compulsive preoccupation with use of cocaine and related compounds. Tacrine, a medication
that is currently prescribed for Alzheimer's disease, can decrease the amount of cocaine
injections that laboratory animals choose to inject by vein. This project will determine if
tacrine can also decrease cocaine-motivated behavior for human subjects in a laboratory
setting.

Cognition and Exercise Training [Recruiting]
The aim of study is to investigate the impact of two different training modalities (high
intensity interval training (HIIT) versus moderate intensity continuous exercise training
(MICET) on cognitive performance, cerebral oxygenation, cardiac output and physical fitness
in older healthy adults, patients with metabolic syndrome, coronary heart disease and heart
failure. The investigators hypothesized that HIIT modality will lead to a larger
improvement in physical fitness (i. e. VO2peak), cardiovascular parameters (cardiac output
and stroke volume) and cognitive performance at rest and during submaximal exercise. The
primary endpoint will be the improvement in cognitive performance.

Evaluation of Four Surgical Techniques in Primary Total Hip Arthroplasty [Recruiting]
Current "Minimally Invasive THR" includes: (1) Minimally Invasive Two-Incision THR (MIS-2),
(2) Minimally Invasive Modified Watson-Jones THR (MIS-WJ). In contrast, "mini-incision"
utilizes smaller incision (< 10 cm in definition) to perform the THR which can further be
divided into mini-anterolateral (Mini-AL) and mini-posterolateral (Mini-PL).The purpose of
this study is to investigate how MIS THR can affect the results of THR by a prospective
randomized clinical trial. It is hoped that some new standards could be established for the
total hip replacement surgery.