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Develop and characterise inhibitors of various histone-mediated pathologies

Recent studies have shown that neutrophils, following activation by pathogens or tissue injury, can extrude their chromatin as extracellular networks called neutrophil extracellular traps (NETs) that can capture and kill microbes.

However, NETs, particularly via their associated histones, can also cause tissue injury. In fact, a number of diseases are thought to be NET/histone-mediated, e.g., sepsis, ischemia reperfusion injury, stroke.

We are developing new drugs that inhibit these histone-mediated pathologies and are being investigated at many levels.