Acquired Sideroblastic Anemia

The ultrastructural findings of the bone marrow cells from 15 patients with acquired sideroblastic anemia are presented.[ncbi.nlm.nih.gov]

We report a patient who initially presented with slight anemia and a raised platelet count. Further investigations suggested a diagnosis of primary acquired sideroblastic anemia. Cytogenetic examination revealed a clone with trisomy 8.[ncbi.nlm.nih.gov]

We describe a 63-year-old man who presented with idiopathic acquired sideroblastic anemia and subsequently developed acute myelofibrosis.[ncbi.nlm.nih.gov]

The underlying mechanism is not understood, but, taken separately, these two anomalies commonly present heme metabolic anomalies in the mitochondria.[ncbi.nlm.nih.gov]

The common Xq13 chromosome breakpoint and clinical presentation (IASA) among these three patients and the occurrence of an X-linked type of sideroblastic anemia may suggest that an association exists between X chromosome abnormalities and IASA.[ncbi.nlm.nih.gov]

When do you need to get more aggressive tests: Bone marrow aspiration biopsy should be considered when all other possibilities for a hypoproliferative anemia with a dimorphic blood picture have been ruled out.[psychiatryadvisor.com]

This disorder shows a marked phenotypic variability: some patients have a severe multi-systemic disorder since infancy, including cardiomyopathy and respiratoryinsufficiency that causes early death, while others present in the second or third decade[bloodgenetics.com]

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The Hematology: Diagnosis and Treatment eBook is the ideal mobile resource in hematology ! It distills the most essential, practical information from Hematology: Basic Principles and Practice, 6th Edition - the comprehensive masterwork by Drs.[books.google.com]

These patients may respond to treatment with vitamin B6 (pyridoxine) and folic acid. In some cases of severe anemia without response to treatment support measures such as blood transfusions are necessary.[bloodgenetics.com]

January 09, 1987 Published online: February 25, 2009 Number of Print Pages: 2 Number of Figures: 0 Number of Tables: 0 ISSN: 0001-5792 (Print) eISSN: 1421-9662 (Online) For additional information: Abstract Danazol, a synthetic androgen, was used in the treatment[karger.com]

Treatment The underlying cause determines the course of treatment. Hereditary sideroblastic anemia usually responds to several weeks of treatment with high doses of pyridoxine.[doctor-clinic.org]

The fact that two of these patients had preleukemia and the third had overt acute leukemia may imply that patients with IASA and X chromosome abnormalities have a poor prognosis.[ncbi.nlm.nih.gov]

A normal karyotype carries the most favorable prognosis. Monosomy 7 or deletions of the long arms of chromosome 7 are associated with a worse prognosis. “What if” scenarios.[psychiatryadvisor.com]

Generally, the prognosis depends on the severity of anemia and its response to treatment Proper care should be taken to treat and control complications from MDS.[dovemed.com]

Few patients are eligible for transplant. [ 1 ] Prognosis [ 9 ] The prognosis is very variable. Reversible causes (eg, alcohol or drugs) appear to have no long-term effects if the underlying cause is successfully treated or removed.[patient.info]

Etiology Congenital Diamond-Blackfan anemia (DBA) is a congenital pure red blood cell aplasia that presents in infancy with the following features: Macrocytic ( non-megaloblastic ) anemia in infancy or early childhood (usually diagnosed before one year[amboss.com]

Epidemiology Refractory anaemia with ringed sideroblasts (RARS) may account for 5-15% of all MDS cases. [ 4 ] Aetiology Congenital The most common inherited sideroblastic anaemia is X-linked sideroblastic anaemia (XLSA) caused by mutations of the erythroid-specific[patient.info]

Some patients with sideroblastic anemias may benefit from phlebotomy to prevent hemochromatosis. Phlebotomy increases the rate of erythropoiesis and uses up excess iron stores; thus, it reduces serum and total-body iron levels.[doctor-clinic.org]

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