telomere length reflects lifetime cumulative oxidative stress from environmental exposures, such as cigarette smoking and chronic inflammation. shortened telomere length is thought to cause genomic instability and has been associated with several cancers. we examined the association of telomere length in peripheral leukocyte dna with gastric cancer risk as well as potential confounding factors and risk modifiers for telomere length-related risk. in a population-based study of gastric cancer cond ...

host immune responses are known determinants of gastric cancer susceptibility. we previously reported an increased gastric cancer risk associated with common variants of several t helper type 1 (th1) cytokine genes in a population-based case-control study in warsaw, poland. in the present study, we augmented our investigation to include additional th1 genes as well as key genes in the th2 and th3 pathways. analysis of 378 cases and 435 age- and sex-matched controls revealed associations for poly ...

pcr-based diagnosis of helicobacter pylori infection in polish children and adults.

infection and associated disease caused by helicobacter pylori are common in poland, as in much of eastern europe, although the genotypes of strains have not been much studied, especially in terms of traits that might be important in disease. this study developed a sensitive and efficient polymerase chain reaction (pcr) test for the presence of h. pylori in gastric biopsy samples with urea gene-specific primers and primers for the virulence-associated cag pathogenicity island (pai). these tests ...

[changes in gastric mucosa and helicobacter pylori infection in young health volunteers].

they examined 114 young health volunteers to establish a frequency of inflammation of gastric mucous membrane and(or) duodenal bulbous, a frequency of helicobacter pylori infection and interdependence between infection and inflammation, smoking and nourishment. they evaluated a frequency and intensity of inflammation in antrum, fundus and duodenal bulbus and present of helicobacter pylori using an urease test and microscopic examination. they noted in young inhabitants of warsaw, appearance of a ...