Abstract

Vitamin D deficiency has been implicated in various diseases including cancer and auto
immune diseases. The present study attempts to establish a relation between vitamin D
deficiency, thyroid hormones and TSH in subclinical hypothyroidism.100 newly
diagnosed patients with subclinical hypothyroidism were divided into three groups
according to vitamin D levels. Mean plasma TSH and T3 values decreased with
increasing vitamin D values and T4 increased with increasing vitamin D tertiles.
However , intergroup comparison showed no statistically significant changes .In
females, negative correlation between vitamin D and TSH was statistically significant
(p=0.014).The prevalence of vitamin D deficiency, insufficiency and sufficiency in 100
patients was found to be 38%, 38% and 24%. The study indicates the prevalence of
vitamin D deficiency in subclinical hypothyroidism, but further studies are needed to
determine whether it is a causative factor in the pathogenesis of the disease or a
consequence.