Buffalo Bills at New York Jets: This is the first of two matchups (presumably) this season between rookie quarterbacks Geno Smith and EJ Manuel, so there's that. USA TODAY Sports

Jacksonville Jaguars at Seattle Seahawks: Raise your hand if you think the Jaguars have even a remote shot at pulling off a shocker in Seattle. USA TODAY Sports

San Diego Chargers at Tennessee Titans: For the second straight week, the Chargers travel to the eastern time zone for a 10 a.m. PT kickoff. Will lightning strike twice? USA TODAY Sports

Arizona Cardinals at New Orleans Saints: Cardinals offense is vastly improved, but is it improved enough to keep up with the Saints on the road? USA TODAY Sports

New York Giants at Carolina Panthers: The Giants' offense has been a turnover machine through two games. Will the Panthers take advantage? USA TODAY Sports

Cleveland Browns at Minnesota Vikings: The Browns should be just what the Vikings need to get their first win. USA TODAY Sports

Oakland Raiders at Denver Broncos: The Raiders defense has shown signs of improvement through two games, but this is Peyton Manning and Co. they'll be facing on "Monday Night Football". USA TODAY Sports

St. Louis Rams at Dallas Cowboys: It could be a long day for Sam Bradford going up against a much-improved Cowboys defense. Or this could be a surprisingly entertaining affair. USA TODAY Sports

Atlanta Falcons at Miami Dolphins: The Falcons will have to figure out what to do without Steven Jackson and Sean Weatherspoon as they face one of the surprise 2-0 teams of the young NFL season. USA TODAY Sports

Green Bay Packers at Cincinnati Bengals: The talent on the Bengals defense is undeniable. We'll find out just how good they are this week against the high-powered Packers offense. USA TODAY Sports

Tampa Bay Buccaneers at New England Patriots: The Buccaneers defense just kept the Saints offense in check last week. Will they do the same to Tom Brady and Co.? USA TODAY Sports

Detroit Lions at Washington Redskins: Robert Griffin III has to get back to normal self at some point. This could be the game it happens. USA TODAY Sports

Chicago Bears at Pittsburgh Steelers: Jay Cutler and the Bears have been comeback kings so far this season. The Steelers, meanwhile, are just looking to come back from starting the season 0-2. USA TODAY Sports

Indianapolis Colts at San Francisco 49ers: Jim Harbaugh and Andrew Luck made each other while at Stanford. Now mentor faces pupil in one of the week's marquee matchups. USA TODAY Sports

Houston Texans at Baltimore Ravens: What a game for Ed Reed to decide to make his Texans debut. USA TODAY Sports

Kansas City Chiefs at Philadelphia Eagles: Eagles fans wanted Andy Reid out of Philadelphia, but he's back already to face his old team at Lincoln Financial Field in the juiciest storyline of Week 3. USA TODAY Sports