Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.This Brief Profile is covered by the ECHA Legal Notice.

N-hexane

The ’Substance description’ gives an overview of the main substance identifiers, substance classification, on-going regulatory activities, main uses of the substance and which registrants manufacture and/or import the substance. By summarising this information in a single page, ECHA aims to make this information accessible in a user-friendly way in line with the Agency’s goals and standards.

Data from all dossiers registered and the Classifications and Labelling Inventory (C&L) for the same substance are used to generate the Brief Profile. The information provided in the free-text fields is not published in the Brief Profiles.

The Brief Profile is automatically generated; information requirements under different legislative frameworks may, therefore, not be up-to-date or complete. For accuracy reasons, substance manufacturers and importers are responsible for consulting official sources. This Brief Profile is covered by the ECHA Legal Disclaimer.

Generating the Brief Profiles

The Brief Profile summarises the non-confidential data on substances as it is held in the databases of the European Chemical Agency (ECHA), including data provided by third parties. The Brief Profile is produced based on data in ECHA’s databases and maintained by the Agency, and therefore the Brief Profile as a dissemination tool falls under ECHA’s responsibility.

Due to the quantity of information and the number of chemicals, the Brief Profile is automatically generated based on the information available and is not manually verified. For sections such as substance use, chemical properties and the classification and labelling of substances, the quantity and quality of the information is the responsibility of manufacturers and importers. While the Agency tries to aggregate the information on chemicals in the best possible way, ECHA cannot check whether all the information provided by industry is free of errors.

Updates

Brief Profiles are updated regularly and new information is added when available. Since the source data can be updated at any time while the Brief Profiles are updated at intervals, a slight delay in the publication of information may occur.

The date of the last update corresponds to the publication date of the Brief Profile and not necessarily to the date in which the update occurred in the source data (registered dossiers, the C&L Inventory or a regulatory process).

Furthermore, updates in the source data may not always result in an update of the Brief Profile. For example, an update in a section of a dossier that is not displayed in the Brief Profile will not result in an update of the Brief Profile.

Dealing with Brief Profile errors

If you have any comments or suggestions, please contact ECHA using our contact form.

The ‘Scientific properties’ section gives an overview of summarised scientific data from registered dossiers. By summarising the endpoint study data, ECHA aims to make this information accessible in a user-friendly way in line with the Agency’s goals and standards.

All the source data on which the summaries on this page are based, is provided by industry and stored in the ECHA databases. Data from all dossiers registered for the same substance is used in the summarisation and aggregation process, as it is presumed that all data submitted by the registrants is relevant for the substance being registered. If the test material used is different from the substance being registered an indication will be provided. Please note that the information provided in the free-text fields is not published in the brief profiles.

Information in the ‘Scientific properties’ section is structured by substance properties, further broken down into endpoints. Each endpoint includes three information blocks:

Study results – this information is collected from those endpoint study records provided by registrants of REACH dossiers which are flagged as Key or Weight of Evidence studies, and which have an indicated reliability (i.e. Klimisch score) of 1 or 2. Other types of studies are not processed for the Brief Profiles.

Summary data – this information is collected from the endpoint summaries provided by registrants of REACH dossiers.

Note: Information presented in this section is generated as part of an automatic process, i.e. there is no manual verification or assessment of the correctness of the data. If no data is available in the registered substance dossiers, this will be indicated by a notification stating ‘Data not provided by the registrant’.

Summarisation and prioritisation of data

There are four methods to aggregate and summarise data, depending on the available data and endpoint. An icon is displayed to indicate the type of aggregation and summarisation performed:

[C] Concatenate distinct – Value types are ranked from most to least commonly provided, with a % attributed based on the count of total values provided.

[M/C] Most conservative - Most conservative of all the data values provided, applying a precautionary principle (e.g. the lowest threshold or most hazardous statement)

[P] Prioritisation – The result to be displayed is based on a set of criteria. For example, for endpoints related to (eco)toxicology four main types of criteria exist to prioritise the display of information: test species, dose descriptor, duration and measurement units. For Toxicology endpoint summaries two other criteria can be applied: Test type (Chronic, subchronic and subacute) and endpoint conclusion.

The precise data summarisation methods are specified per endpoint summary/study.

When more than one numerical result is available per endpoint the count is displayed between square brackets.

Units and data are normalised when possible and therefore the unit of measure/order of magnitude in the Brief Profile data may not correspond exactly to the one in the registered dossier. For temperature for example, data is standardised and displayed in Celsius (°C). For other data an order of magnitude logic might apply; e.g. 1 000 g will be displayed as 1 kg.

Processed studies and data-waiving

Due to the number of the substances and the associated information, substance data is processed and aggregated in an automatic process. Therefore, data has to fit the format and aggregation logic that is used for the Brief Profile.

Though the Agency aims to include as many studies as possible in the Brief Profile endpoint study results/summaries, those studies which do not fit the format or miss crucial information (such as measurement conditions) cannot be processed and therefore will not be included on this page. These study results can however be consulted when opening the source data.

The number of studies provided is indicated by ‘[x] studies submitted’, while the actual number of studies processed for the endpoint is indicated by ‘[x] studies processed’.

Data waiving

If only waived data is available for the substance, following justifications for data-waiving can be displayed in the Brief Profile:

Study technically not feasible

Study scientifically unjustified

Exposure considerations

Other justification

Excluded endpoints

Some endpoints are not included in the Brief Profile due to the use of free text and/or complex field(s) in the reporting of information, which cannot be easily summarised by an automatic algorithm. Please see the registered dossiers for substance information for the following endpoints:

Particle size distribution

Stability in organic solvents and identity of relevant degradation products

Substance Description

Substance identity

Help

The ’Substance identity’ section links substance identification information from all databases that are maintained by ECHA. The substance identifiers – if available and not claimed confidential – displayed in the ’Substance identity’ section of the Brief Profile are:

EC name/number

IUPAC name/number

CAS number

Index number

Molecular formula

Smiles

InChI

In addition, information on the type of substance, origin, number and type of registered compositions and other places where the substance is listed are displayed in this section.

EC (European Community) name/number

The EC name and number are the official identifiers for substances within the European Union and can be found in the EC Inventory.

The EC Inventory is a combination of three independent European lists of substances from the previous EU chemicals regulatory frameworks (EINECS, ELINCS and the NLP-list). More information about the EC Inventory can be found here. If the substance has no EC number attributed, ECHA will attribute a list number. These numbers start with 6, 7, 8 or 9.

IUPAC name/number

An IUPAC name is based on the international standard chemical nomenclature set by the International Union of Pure and Applied Chemistry (IUPAC).

The IUPAC nomenclature is a systematic way of naming chemical substances, both organic and inorganic. In IUPAC nomenclature, prefixes, suffixes and infixes are used to describe the type and position of functional groups in the substance.

If more than one IUPAC name is available from REACH registered dossiers, all IUPAC names are displayed in ‘Other names’ section of the Brief Profile.

See the official IUPAC website for more information on the International Union of Pure and Applied Chemistry.

CAS (Chemical Abstract Service) registry number

The CAS number is the substance numerical identifier assigned by the Chemical Abstract Service, a division of the American Chemical Society, to substances registered in the CAS registry database. A substance may have more than one CAS number associated. In this case, the preferred CAS number is displayed first. More about CAS and the CAS registry can be found here.

Index number

The Index number is the identification code given to substances in Part 3 of Annex VI to the CLP Regulation ((EC) No 1272/2008). A distinct classification and labelling corresponds to each Index number.

The Index number for each substance is in the form of a digit sequence of the type ABC-RST-VW-Y. ABC corresponds to the atomic number of the most characteristic element or the most characteristic organic group in the molecule. RST is the consecutive number of the substance in the series ABC. VW denotes the form in which the substance is produced or placed on the market. Y is the check-digit calculated in accordance with the 10-digit ISBN method.

Molecular formula

The molecular formula identifies each type of element by its chemical symbol and identifies the number of atoms of each element found in one discrete molecule of the substance. If such information is available in ECHA’s database and is it not claimed confidential, the molecular formula and molecular structure will be displayed here.

SMILES

SMILES is the acronym for Simplified Molecular Input Line Entry Specification, a chemical notation system used to represent a molecular structure by a linear string of symbols.

With standard SMILES, the name of a molecule is synonymous with its structure: it indirectly shows a two dimensional picture of the molecular structure. Since a two dimensional chemical structure can be drawn in various ways, there are several correct SMILES notations for one molecule.

The basis of SMILES is the representation of a valence model of a molecule. SMILES notations are comprised of atoms (designated by elemental symbols), bonds, parentheses (used to show branching), and numbers (used for cyclic structures).

InChI

InChI is an abbreviated name for IUPAC International Chemical Identifier, a chemical identifier developed and supported by the InChI Trust.

InChIs consist of text strings comprising different layers and sublayers of information separated by slashes (/). Each InChI string starts with the InChI version number followed by the main layer. This main layer contains sublayers for the chemical formula, atom connections and hydrogen atoms. Depending on the structure of the molecule the main layer may be followed by additional layers e.g. for charge, stereo–chemical and/or isotopic information.

Molecular structure

Molecular structure displayed in this section is based on InChI annotation from IUCLID reference substances database and stored in the ECHA database. The structure is a computer generated visualisation of the molecular structure derived from the InChI character string.

Type of substance

Registrants can identify their substance as being a mono-constituent substance, multi-constituent substance, UVCB, polymer or specify another type. If more than one type of substance is registered, both types will be displayed.

Origin

Registrants can identify the origin of their substance as being:

Element

Inorganic

Organic

Organometallic

Petroleum product

Other

If more than one type of substance is registered, both types will be displayed.

Registered compositions (additives and impurities)

The total number of non-confidential registered compositions submitted in REACH dossiers are displayed here. If there are additives and impurities relevant for the substance classification, these are also indicated.

Within the context of REACH, impurities are unintended constituents present in a substance as manufactured. It may, for example, originate from the starting materials or be the result of secondary or incomplete reactions during the production process. While it is present in the final substance, it was not intentionally added. In most cases, impurities constitute less than 10% of the substance.

Additives are the constituents which have been intentionally added during the manufacturing process to stabilise the substance.

Substance listed

Provides information if the substance has been identified by one of the following previous EU chemicals regulatory frameworks:

Hazard classification & labelling

Hazard classification and labelling

The ‘Hazard classification and labelling’ section shows the hazards of a substance through a standardised system of statements and pictograms, as has been established under CLP (Classification Labelling and Packaging) Regulation. The CLP Regulation makes sure that the hazards presented by chemicals are clearly communicated to workers and consumers in the European Union. The CLP Regulation uses the UN Global Harmonised System (GHS) and European Union Specific Hazard Statements (EUH).

This section searches three sources for information (harmonised classification and labelling (CLH), REACH registrations and CLP notifications). The source of the information is mentioned in the introductory sentence of the hazard statement.

More information about classification and labelling can be found in the Regulations section of ECHA website.

Please note:

The purpose of the information provided under this section is to highlight in a readable format the substance hazardousness. It does not represent a new labelling, classification or hazard statement. Other relevant information includes the following:

Substances may have impurities and additives that lead to different classifications. However, substance notifications in the Brief Profile are aggregated independently of the impurities and additives.

Hazard statements were adapted to improve readability and may not correspond textually to the hazard statements codes description in the European Union Specific Hazard Statements (EUH) or UN Global Harmonised System (GHS).

To see the full list of notified classifications and have more information on impurities and additives relevant to classification, you can consult the C&L Inventory.

Harmonised classification and labelling (CLH)

The Hazard classification and labelling section uses the signal word, pictogram(s) and hazard statements of the substance under the harmonised classification and labelling (CLH) as its primary source of information. Substance classifications under CLH are agreed at the Community level. Harmonisation is based on the substance’s physical, toxicological and eco-toxicological hazard assessment.

It is possible that the harmonisation is introduced through an amendment to the CLP Regulation. In that case, the ATP (Adaptation to Technical Progress) number is displayed. More information on CLH can be found here.

If the substance is classified under more than one CLH entry (e.g. disodium tetraborate EC no. 215–540–4, is covered by three harmonisations – 005–011–00–4&semi; 005–011–01–1&semi; 005–011–02–9), CLH information cannot be displayed in the Brief Profile as the differences between the CLH classifications require manual verification. If a substance is classified under multiple CLHs, a link to the C&L Inventory is provided to allow users to view CLH information manually, instead of having the information automatically generated in the Brief Profile.

Classification and labelling under REACH

Additional information on classification and labelling (C&L) – if available – is derived from REACH registration dossiers submitted by industry. This information has not been reviewed or verified by ECHA, and may change without prior notice. REACH registration dossiers have greater data requirements (support studies) than notifications under CLP. When submitted by the lead of a joint submission, the classifications may also reveal agreement between companies.

Notifications under the Classification, Labelling and Packaging (CLP) Regulation

If additional information derived from classification and labelling (C&L) notifications to ECHA under the CLP Regulation exists, this will be displayed below the information derived from harmonised classification and labelling and REACH registrations. These notifications can be provided by manufacturers, importers and downstream users. ECHA maintains the C&L Inventory, but does not review or verify the accuracy of the information.

For readability purposes, only the pictograms, signal words and hazard statements referred to in more than 5% of the notifications under CLP are displayed.

Danger! According to the harmonised classification and labelling (CLP00) approved by the European Union, this substance may be fatal if swallowed and enters airways, is toxic to aquatic life with long lasting effects, is a highly flammable liquid and vapour, is suspected of damaging fertility, may cause damage to organs through prolonged or repeated exposure, causes skin irritation and may cause drowsiness or dizziness.

Additionally, the classification provided by companies to ECHA in REACH registrations identifies that this substance is suspected of damaging fertility or the unborn child.

Additionally, the classification provided by companies to ECHA in CLP notifications identifies that this substance causes serious eye irritation.

Breakdown of all 2626 C&L notifications submitted to ECHA

Hazard classification & labelling graph

The chart displays the number of matching substance classifications (hazard class, categories and hazard statements) provided by manufacturers and importers under REACH and CLP notifications, as well as whether the substance is defined under harmonised classification and labelling (CLH).

The results of matching substance classifications are displayed in percentages of the total number of notifications. The bars indicate the number of matching classifications, i.e. the level of agreement, in substance classification between the REACH registrants (dark blue bar) and CLP notifiers (light blue bar), as well as between the notified classifications and the approved harmonised classification.

Harmonised classifications (√ - check mark)

The (√- check mark)-icon indicates the classification is defined under harmonised classification and labelling (in accordance with the CLP Regulation) and made obligatory at Community level to ensure an adequate risk management throughout the European Community.

REACH & CLP classifications (bar)

The dark blue bar illustrates the percentage of matching substance classifications provided by manufacturers and importers in a REACH registration dossier. Classifications under REACH have to be supported by data (support studies).

The light blue bar illustrates the percentage of matching substance classifications provided by manufacturers and importers in CLP notifications.

Divergent classifications and impurities

The physical state and form of a substance can play a significant impact when the hazards of a substance are assessed. REACH and/or CLP notifiers may classify a substance differently based on different studies or the way they access the data.

For example, substance impurities can constitute a valid reason for a different classification of the substance. Different compositions or impurity profiles often lead to different classifications. If impurities and/or additives have been identified, an informative sentence is displayed below the graphic.

Different classifications can also be due to technical errors made during the notification process.

To have more information on impurities relevant to classification you can consult the C&L Inventory entry for the substance, or the disseminated registration dossier.

Aquatic Chronic 2

H411

Flam. Liq. 2

H225

Asp. Tox. 1

H304

Repr. 2

H361f

Skin Irrit. 2

H315

STOT RE 2

H373

STOT SE 3

H336

Eye Irrit. 2

H319

STOT RE 1

H372

STOT SE 3

H335

Acute Tox. 3

H331

Aquatic Chronic 4

H413

Not Classified

STOT RE 2

H372

STOT SE 2

H371

0%10%20%30%40%50%60%70%80%90%100%

Harmonised Classification

REACH registration dossiers notifications

CLP notifications

At least one notifier has indicated that an impurity or an additive present in the substance impacts the notified classification.

Properties of concern

Properties of concern

The ‘Properties of concern’ section shows ECHA-assigned graphical indicators for certain substance properties that are regarded as critical for human health and/or the environment based on the information provided to the Agency. The following properties have been highlighted as critical:

C – This substance was identified as a carcinogenic (i.e. classified in Carcinogenicity categories 1A or 1B) in the EU harmonised classification and labelling and/or in a REACH registration dossier. More information about carcinogenicity here.

M – This substance was identified as Mutagenic (i.e. classified in Mutagenicity categories 1A or 1B) in the EU harmonised classification and labelling and/or by a REACH registration dossier. More information about mutagenicity here.

R – This substance was identified as toxic to reproduction (i.e. classified in reproductive toxicity categories 1A or 1B) in the EU harmonised classification and labelling and/or by a REACH registration dossier. More information about reproductive toxicity here.

Ss – This substance was identified as a skin sensitiser (i.e. classified in skin sensitisation categories 1, 1A or 1B) in the EU harmonised classification and labelling and/or by a REACH registration dossier. More information about skin sensitiser here.

Sr – This substance was identified as a respiratory sensitiser (i.e. classified in respiratory sensitisation categories 1, 1A or 1B) in the EU harmonised classification and labelling and/or by a REACH registration dossier. More information about respiratory sensitiser here.

PBT – This substance was identified as persistent, bioaccumulative and toxic (PBT) by at least one REACH registrant (i.e. it is PBT/vPvB). More information about persistent, bioaccumulative and toxic substances here.

The substance properties displayed in this section (with the exception of PBT properties) are derived from harmonised classification and labelling (CLH) and/or REACH registered dossier information. In case the substance classification is not harmonised and the substance is not registered the properties are derived from classifications provided in CLP notifications. PBT properties are derived from REACH registered substances dossiers.

Critical property indentification: Where less than 90% of the notifiers provide the same classification to derive the critical property, the border of this critical property icon is displayed as dashed.

Impurities or additives: When a specific critical property is associated with compositions with impurities and/or additives, the respective critical property icon has a * associated.

Please note: The icons in this section are only meant as visual indicators to help communicate information about the abovementioned critical properties. Unlike the pictograms in the ‘Classification and Labelling’ section, these icons are not determined by any legislative procedure and have the sole purpose of being informative in the context of InfoCards and Brief Profiles.

Regulatory activities

Regulatory activities

The ‘Regulatory activities’ section provides an overview of the regulatory activities that are related to the substance. For general information about any of the different regulations which currently fall under ECHA’s mandate please see the links below.

Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH)The REACH Regulation (1907/2006) entered into force on 1 June 2007. The regulation aims improve the protection of human health and the environment from the risks that can be posed by chemicals, while enhancing the competitiveness of the EU chemical industry.

The REACH regulatory processes identified for the Brief Profile are:

Registration

Pre-registration – indicated if the substance is included in the list of pre-registered substances. Pre-registration allows companies to continue manufacturing and importing their phase-in substances for several years until the registration deadline is reached.

Registration – indicated if there is at least one dossier registered and disseminated for the substance, how many non-confidential registrations are active and/or inactive and the type of submissions (joint and/or individual).

Evaluation

Dossier evaluation – indicated if at least one registered dossier for the substance has been evaluated under REACH for compliance check or testing proposal evaluation and associated decision(s) published on the ECHA website.

Substance evaluation – indicated if the substance is or was included in the Community rolling action plan (CoRAP). The CoRAP list includes substances that could pose a risk to human health or the environment and whose (potentially hazardous) properties are to be evaluated by the Member States in the next three years. After evaluation, proposals may be made for further regulatory action regarding the substance.

Authorisation

Candidate List – indicates if the substance is included in the candidate list of substances of very high concern (SVHCs). The Candidate List includes substances that are subject to additional protocols and reporting obligations and which may eventually be included in the Authorisation list, further limiting their use.

Authorisation list (Annex XIV) – indicates if the substance is included in the Authorisation List. These substances cannot be placed on the market or used after a given date, unless an authorisation is granted for their specific use, or the use is exempted from authorisation.

Restriction

Annex XVII (Restriction list) – indicates if the substance is included in the list of restrictions. The Restriction list describes the conditions for the manufacture, placing on the market or use of certain substances, either on their own or in mixtures or articles.

Classification, Labelling and Packaging (CLP)The CLP Regulation (1272/2008) entered into force on 20 January 2009. The goal of CLP is to make sure that hazards presented by chemicals are clearly communicated to workers and consumers in the European Union through a system of classifying and labelling of chemicals.

The CLP regulatory processes identified for the Brief Profile are:

Harmonised C&L– indicates if a European Union harmonised classifications and labelling has been assigned to the substance according to Annex VI to CLP and subsequent ATPs.

Notification – indicates that notified C&L’s have been submitted to ECHA for a substance.

The BPR (528/2012) entered into force on 1 September 2013. The BPR addresses the placing on the market and use of biocidal products, which are used to protect humans, animals, materials or articles against harmful organisms, like pests or bacteria, by regulating the active substances contained in a biocidal product.

Biocidal Products Regulation (BPR)

Active Substance:

Biocidal Products:

Prior Informed Consent (PIC)

Annex I:

Annex V:

About this substance

About this substance

The ’About this substance’ section provides an overview of the volume in which this substance is manufactured or imported to the European Economic Area (EU28 + Iceland, Liechtenstein and Norway). Data for calculating the ’total tonnage’ band is extracted from REACH registered dossiers for the last year reported on the tonnage manufactured or imported, unless the tonnage band has been claimed confidential. The ‘total tonnage’ band published does not necessarily reflect the registered tonnage band(s).

Additionally, if available, information on the use of the substance and how consumers and workers are likely to be exposed to it can also be displayed here. The information is aggregated from REACH registered dossiers provided by industry through a use descriptor system based on five separate descriptor lists which in combination with each other form a brief description of use and exposure for certain life cycle stage.

The use information is displayed per relevant life cycle stage of the substance.

Manufacture stage includes processes by which the substance is manufactured from raw materials. Operations which are necessary for the handling of a substance on its own in the manufacturing for export or placing on the EU market are considered to be part of the manufacturing stage (e.g. filling into appropriate containers, storage or addition of stabiliser). If a substance is directly exported after manufacture, all activities with the substance will be reported under this stage.

Formulation or re-packing stage corresponds to specific activities meant to produce a mixture to be placed on the market. This means that during formulation, the substance is transferred and mixed with other substances. It corresponds to activities taking place at industrial sites. This stage also includes chemical distributorsâ activities such as repacking (which involves transfer of the substance).

End-use stage means the use of a substance as such or in a mixture (by professional workers (widespread uses), by consumers or at industrial sites), a last step before the end-of-life of the substance, namely before the substance is consumed in a process by reaction during use (including intermediate use), is emitted to waste streams or the environment or is included into an article.

(Article) service life stage means the period of time a substance incorporated into an article remains in service or in use. Articles containing the substance can be used or processed by consumers, by workers at industrial sites and/or by professional workers. This also includes processing of semi-finished articles by workers with the aim of producing finished articles or repair and maintenance work like for example sanding of surfaces.

Use Descriptors

The chemical product category (PC) describes the types of chemical products in which the substance is finally contained when it is supplied to end-users (by industrial, professional or consumer users). Examples include hydraulic fluids, perfumes and air care products. This category also describes uses as intermediate and under controlled conditions.

The sector of use category (SU) describes in which sector of the economy the substance is used. This includes mixing or re-packing substances at the formulator’s level as well as industrial, professional and consumer end-uses (e.g. building and construction work or manufacture of food products).

The environmental release category (ERC) describes the broad conditions of use from the perspective of release to the environment (e.g. if the use occurs in industrial setting, if it is indoor use in long-life materials with a low release rate (e.g. flooring, furniture, toys, etc).

The article category (AC) describes the type of article into which the substance has eventually been processed. This also includes mixtures in their dried or cured form (e.g. dried printing ink in newspapers; dried coatings on various surfaces).

Precautionary measures and safe use

This section provides information on the recommended measures to minimise or prevent adverse effects resulting from exposure to a hazardous product, or improper storage or handling of a hazardous product. The recommendations are based on the precautionary statements provided in REACH registration dossiers.

If information on guidance on safe use is available in REACH registered dossiers, a link is displayed. Information in the guidance on safe use section consists of recommendations by a substance registrant(s) on the proper use of the substance in various situations. Examples include recommended measures on fire-fighting, transport, recycling and disposal.

This substance is used in the following products: pH regulators and water treatment products and laboratory chemicals.

This substance is used in the following areas: health services and scientific research and development.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, roller or brushing applications, batch processing in synthesis or formulation with opportunity for exposure, laboratory work, non-industrial spraying, treatment of articles by dipping and pouring and hand mixing with intimate contact only with personal protective equipment available.

Other release to the environment of this substance is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners), outdoor use, indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters) and outdoor use in close systems with minimal release (e.g. hydraulic liquids in automotive suspension, lubricants in motor oil and break fluids).

ECHA has no public registered data indicating whether or in which chemical products the substance might be used.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, batch processing in synthesis or formulation with opportunity for exposure, transfer of substance into small containers, laboratory work, mixing in open batch processes and production of mixtures or articles by tabletting, compression, extrusion or pelletisation.

Release to the environment of this substance can occur from industrial use: formulation of mixtures, in processing aids at industrial sites, manufacturing of the substance, formulation in materials, in the production of articles and as processing aid.

This substance is used in the following products: pH regulators and water treatment products, laboratory chemicals and polymers.

This substance is used in the following areas: formulation of mixtures and/or re-packaging. This substance is used for the manufacture of: chemicals.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed batch processing in synthesis or formulation, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, batch processing in synthesis or formulation with opportunity for exposure and transfer of substance into small containers.

Release to the environment of this substance can occur from industrial use: in processing aids at industrial sites, of substances in closed systems with minimal release, in the production of articles, as processing aid, formulation of mixtures, formulation in materials and manufacturing of the substance. Other release to the environment of this substance is likely to occur from: outdoor use as processing aid.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, batch processing in synthesis or formulation with opportunity for exposure, laboratory work and transfer of substance into small containers.

Release to the environment of this substance can occur from industrial use: manufacturing of the substance, formulation of mixtures and in processing aids at industrial sites.

Precautions for using this substance have been recommended by its registrants under REACH, as follows:

General statements

Read label before use. Keep out of reach of children.

Prevention statements

When handling this substance: take actions to prevent static discharges; do not breathe the dust, fume, gas, mist, vapours or spray; keep away from heat, sparks, open flames and/or hot surfaces – No smoking; use only outdoors or in a well-ventilated area; use explosion-proof equipment (electrical/ventilating/lighting/etc.); avoid release to the environment; wear protective gloves and/or clothing, and eye and/or face protection as specified by manufacturer/supplier.

Response statements

In case of incident: If swallowed: immediately call a poison center or doctor/physician. Do not induce vomiting.

Storage statements

Store this substance locked up.

Disposal statements

The substance must be disposed in accordance with local/regional/national/international regulation.

Registrants/suppliers

This section provides information on suppliers, importers or manufacturers of a substance (active and inactive) that have to register their substance under REACH.

Registration status

Status in REACH-IT

Displayed in Brief Profile

Active

Always as Active

Cease manufacture

Always as Inactive

Revoked registrations

Active/Inactive (pending). Due to ongoing appeals, all registrations flagged as revoked are published as Active pending the appeal outcome. When the appeal outcome is known, the registration will appear as Inactive

Annulled registrations

In the case of a merge between two companies having a registration for the same substance, the higher tonnage band registration is maintained as active, and the other registration is annulled. The annulled registration is still legally valid and considered as an active registration, because the registration number could be present on safety fata sheets and may already be communicated throughout the supply chain.

Under specific conditions, a registrant can claim confidentiality of their identity. If there is a confidentiality claim, an indication is provided with the tag [Confidential].

Other names

Other Names

This list of names is generated by the aggregation of all non-confidential names registered and/or notified by registrants. Names identified by ECHA regulatory activities are also displayed in this section.This list of names is generated by the aggregation of all non-confidential names registered and/or notified by registrants. Names identified by ECHA regulatory activities are also displayed in this section.

Scientific properties

Physical and chemical properties

Physical and Chemical PropertiesThis section summarises physical and chemical property values from all registered dossiers in ECHA’s databases for the substance.

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Appearance / physical state / colour

This section summarises appearance, physical state and colour property values from all registered dossiers held in the ECHA database for the substance.

More information on processable studies and data-waiving is available in the section help of the ‘Scientific properties’ header.

Study results

If more than one value is available, results are displayed as concatenated distinct values, ordered from most to least commonly provided, with the percentage of provided values appended. The percentage is based on the count of values provided.

Physical state

For substance’s physical state at 20°C and 1 013 hPa, registrants can classify their substance as:

Solid

Liquid

Gaseous

Form

For substance’s form, registrants can classify their substance as:

Aerosol dispenser: not specified

Aerosol dispenser: foam aerosol

Aerosol dispenser: spray aerosol

Gas

Gas: vapour

Gas under pressure: compressed gas

Gas under pressure: dissolved gas

Gas under pressure: liquefied gas

Gas under pressure: refrigerated liquefied gas

Liquid

Liquid: viscous

Liquid: volatile

Liquid – liquid: emulsion

Liquid – solid: mixture of

Semi–solid (amorphous): gel

Solid

Solid: bulk

Solid: compact

Solid: crystalline

Solid: fibres

Solid: filaments

Solid: flakes

Solid: granular

Solid: pellets

Solid: particulate/powder

Solid: nanomaterial, surface–treated

Solid: nanomaterial, no surface treatment

Solid: nanomaterial

Solid – liquid: aqueous solution

Solid – liquid: suspension

Solid – solid: alloy

Aerosol

Compact

Crystalline

Dispersion

Fibre

Filaments

Flakes

Liquefied gas

Nanomaterial

Particulates

Paste

Pellets

Powder

Refrigerated liquid

Suspension

Viscous

Other

No data

Odour

For substance’s odour, registrants can classify their substance as:

Ammonia-like

Biting

Characteristic of sulphur containing compounds

Characteristic of aromatic compounds

Faint

Garlic-like

Odourless

Pungent

Slight

Sweetish

Other

Type

For substance’s type, registrants can classify their substance as:

Element

Inorganic

Natural substance

Organic

Organometallic

Petroleum product

Other

Summary

Summary data is collected from the endpoint summary(ies) provided by registrants of REACH dossiers.

Physical state at 20°C and 1013 hPa

For substance’s physical state at 20°C and 1013 hPa, registrants can classify their substance as:

Solid

Liquid

Gaseous

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data–waving justifications.

Study results

6 studies submitted

3 studies processed

C Physical state at 20°C and 1013 hPa

Liquid (100%) [3]

Type of Study provided

Studies with data

Key study

3

Supporting study

3

Weight of evidence

Other

Data waiving

no waivers

Summaries

0 summaries submitted

0 summaries processed

No data available

Melting/freezing point

Melting / freezing point

This section summarises the melting and freezing point values from all registered dossiers for the substance.

More information on processable studies and data-waiving is available in the section help of the ‘Scientific properties’.

Study results

If more than one numerical result is available per endpoint, the range of results (min-max) and range of experimental conditions will be presented (RANGE method).

Melting / freezing point provides substance information on the melting/freezing point in °C at a pressure measured in Pa.

Results without measurement conditions (pressure) are not processed for the Brief Profile. Additionally, if registrants select ‘other’ as a unit of measure for pressure, the measurement conditions (and therefore the study results) cannot be processed in the Brief Profile.

Summary

Melting/freezing point at 101 325 Pa provides information on the substance melting/freezing point in °C at a pressure of 101 325 Pa.

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data–waving justifications.

Study results

9 studies submitted

3 studies processed

R Melting / freezing point

-95.35 °C @ 101.3 kPa [3]

Type of Study provided

Studies with data

Key study

3

Supporting study

6

Weight of evidence

Other

Data waiving

no waivers

Summaries

2 summaries submitted

0 summaries processed

No automatically processable data submitted

Boiling point

Boiling point

This section summarises the boiling point values from all registered dossiers for the substance.

More information on processable studies and data-waiving is available in the section help of the ‘Scientific properties’ header .

Study results

If more than one numerical result is available per endpoint, the range of results (min-max) and range of experimental conditions will be presented (RANGE method).Relative density provides substance information on the relatively density (measurement units are not processed for relative density) at a temperature measured in Celsius (°C).

Bulk density provides substance information on the bulk density in (kilo)grams per (centi)metre (cm/m) at a temperature measured in °C.

Density provides substance information on the density in grams per (centi)metre at a temperature measured in °C.

Pour density provides substance information on the pour density in grams per millilitre at a temperature measured in °C.

Tap density provides substance information on the bulk density per grams per millilitre at a temperature measured in °C.

Note: Registrants can also select ‘other’ as the type of density. If so, the data provided is not processed for the Brief Profile.

Summary

Relative density at 20 °C provides information on the substance relative density at 20 °C. If more than one value is found for this section, the range of min-max values will be displayed here.

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data-waving justifications.

Study results

15 studies submitted

3 studies processed

R Boiling point

68.73 °C @ 101.3 kPa [3]

Type of Study provided

Studies with data

Key study

3

Supporting study

3

9

Weight of evidence

Other

Data waiving

no waivers

Summaries

2 summaries submitted

0 summaries processed

No automatically processable data submitted

Density

Density

This section summarises the density values from all registered dossiers for the substance.

More information on processable studies and data-waiving is available in the section help of the ‘Scientific properties’ header.

Study results

If more than one numerical result is available per endpoint, the range of results (min-max) and range of experimental conditions will be presented (RANGE method).Relative density provides substance information on the relatively density (measurement units are not processed for relative density) at a temperature measured in Celsius (°C).

Bulk density provides substance information on the bulk density in (kilo)grams per (centi)metre (cm/m) at a temperature measured in °C.

Density provides substance information on the density in grams per (centi)metre at a temperature measured in °C.

Pour density provides substance information on the pour density in grams per millilitre at a temperature measured in °C.

Tap density provides substance information on the bulk density per grams per millilitre at a temperature measured in °C.

Note: Registrants can also select ‘other’ as the type of density. If so, the data provided is not processed for the Brief Profile.

Summary

Relative density at 20 °C provides information on the substance relative density at 20 °C. If more than one value is found for this section, the range of min-max values will be displayed here.

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications.

Study results

15 studies submitted

3 studies processed

R Relative density

0.661 @ 25 °C [3]

Type of Study provided

Studies with data

Key study

3

Supporting study

12

Weight of evidence

Other

Data waiving

no waivers

Summaries

2 summaries submitted

0 summaries processed

No automatically processable data submitted

Vapour pressure

Vapour pressure

This section summarises the vapour pressure values from all registered dossiers for the substance.

More information on processable studies and data-waiving is available in the section help of the ‘Scientific properties’ header.

Study results

If more than one numerical result is available per endpoint, the range of results (min-max) and range of experimental conditions will be presented (RANGE method).

Vapour pressure provides substance information on the vapour pressure in Pa at a temperature measured in °C.

Note: Registrants can also select ‘other’ as the unit of measure for pressure. If so, the pressure data provided is not processed for the Brief Profile.

Summary

Vapour pressure provides substance information on the vapour pressure in Pa at a temperature measured in °C.

Type of study provided

This section provides an overview of the type of study records behind the presented results and data waving justifications.

Study results

18 studies submitted

3 studies processed

R Vapour pressure

10 kPa @ 9.8 °C [3]

Type of Study provided

Studies with data

Key study

3

Supporting study

3

12

Weight of evidence

Other

Data waiving

no waivers

Summaries

2 summaries submitted

0 summaries processed

No automatically processable data submitted

Partition coefficient

Partition coefficient

This section summarises the partition coefficient values from all registered dossiers for the substance.

More information on processable studies and data-waiving is available in the section help of the ‘Scientific properties’ header.

Study results

If more than one numerical result is available per endpoint, the range of results (min-max) and range of experimental conditions will be presented (RANGE method).

Pow provides substance information on the partition coefficient type Pow at a temperature measured in °C and acidity in pH.

LogPow provides substance information on the partition coefficient type Pow at a temperature measured in °C and acidity in pH.

Summary

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications

Study results

6 studies submitted

3 studies processed

R Log Pow

4 @ 20 °C and pH 7 [3]

Type of Study provided

Studies with data

Key study

3

Supporting study

3

Weight of evidence

Other

Data waiving

no waivers

Summaries

2 summaries submitted

0 summaries processed

No automatically processable data submitted

Water solubility

Water solubility

This section summarises the water solubility values from all registered dossiers for the substance.

More information on processable studies and data-waiving is available in the section help of the ‘Scientific properties’ header.

Study results

If more than one numerical result is available per endpoint, the range of results (min-max) and range of experimental conditions will be presented (RANGE method).

Water solubility provides substance information on the substance’s solubility in water in grams per litre at a temperature measured in °C. Values provided in ppb and Vol% are provided separately.

Summary

Water solubility provides substance information on the substance’s solubility in water in grams per litre at a temperature measured in °C.

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications.

Study results

6 studies submitted

3 studies processed

R Water solubility (mass/vol.)

9.8 mg/L @ 25 °C and pH 7 [3]

Type of Study provided

Studies with data

Key study

3

Supporting study

3

Weight of evidence

Other

Data waiving

no waivers

Summaries

2 summaries submitted

0 summaries processed

No automatically processable data submitted

Solubility in organic solvents / fat solubility

Solubility in organic solvents / fat solubility

Study results

If more than one result is available per endpoint, the range of results (min-max) and range of experimental conditions will be presented (RANGE method).

Solubility provides substance information on the substance’s solubility in organic solvents/fat in grams per litre at a temperature measured in °C. Registrants can provide data for one or more of the following picklist options:

Standard fat

Acetone

Acetonitrile

Benzene

N-butanol

Cyclohexane

Diethyl ether

Diethyl ketone

Dimethylformamide

DMSO, ethanol

Ethyl acetate

Isopropanol

Methanol

N-octanol

Toluene

Note: Registrants can also select ‘other’ as the solvent. If so, the data provided is not processed for the Brief Profile.

Also, if the registrant selects the ‘mg/100 g solvent’; ‘g/kg solvent’; ‘ppb’; ‘vol%’ and ‘other’ as a unit of measure, the data provided will not be processed for the Brief Profile.

Summary

Solubility in mg/100g standard fat at 20°C provides substance information on the substance solubility in standard fat in milligram per 100 gram at a temperature of 20°C.

Solubility in organic solvents at 20°C provides substance information on the substance solubility in organic solvents in gram per litre at a temperature of 20°C.

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications.

Data not provided by the registrant

Surface tension

Surface tension

This section summarises the surface tension values from all registered dossiers for the substance.

More information on processable studies and data-waiving is available in the section help of the ‘Scientific properties’ header.

Study results

If more than one result is available per endpoint, the range of results (min-max) and range of experimental conditions will be presented (RANGE method).

Surface tension provides substance information on the surface tension in (milli)Newton per metre in a concentration in (milli)gram per metre and at a temperature measured in °C.

Note: Results without a concentration value are not processed for the Brief Profile.

Also, if the registrant selects ‘ppb’; ‘vol%’ and ‘other’ as a unit of measure for the concentration value, the data provided will not be processed for the Brief Profile.

Summary

Surface tension at 20°C provides substance information on the surface tension in (milli)Newton per metre in a concentration in (milli)gram per metre, at a temperature of 20 °C.

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications.

Study results

18 studies submitted

0 studies processed

No automatically processable data submitted

Type of Study provided

Studies with data

Key study

Supporting study

3

12

Weight of evidence

Other

Data waiving

Not feasible

Sci. unjustified

Exposure cons.

Other

3

Summaries

0 summaries submitted

0 summaries processed

No data available

Flash point

Flash point

This section summarises the flash point values from all registered dossiers for the substance.

More information on processable studies and data-waiving is available in the section help of the ‘Scientific properties’ header.

Study results

If more than one result is available per endpoint, the range of results (min-max, RANGE method) will be presented.

Flash point provides substance information on the substance’s flash point at a temperature measured in °C at a pressure measured in Pascal.

Summary

Flash point at 101 325 Pa provides substance information on the substance’s flash point at a temperature measured in °C at a pressure of 101 325 Pascal.

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications.

Study results

15 studies submitted

3 studies processed

R Flash point

-22 °C @ 101.3 kPa [3]

Type of Study provided

Studies with data

Key study

3

Supporting study

12

Weight of evidence

Other

Data waiving

no waivers

Summaries

2 summaries submitted

0 summaries processed

No automatically processable data submitted

Auto flammability

Auto flammability

This section summarises the auto flammability values from all registered dossiers for the substance.

More information on processable studies and data-waiving is available in the section help of the ‘Scientific properties’ header.

Study results

If more than one result is available per endpoint, the range of results (min-max) and range of experimental conditions will be presented (RANGE method).

Autoflammability / Self-ignition provides substance information on the substance’s self-ignition temperature in °C at a pressure measured in Pascal.

Note: Registrants can also select ‘other’ as the unit of measure for pressure. If so, the pressure data provided is not processed for the Brief Profile.

Summary

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications.

Study results

15 studies submitted

3 studies processed

R Autoflammability / self-ignition

225 °C @ 101.3 kPa [3]

Type of Study provided

Studies with data

Key study

3

Supporting study

12

Weight of evidence

Other

Data waiving

no waivers

Summaries

2 summaries submitted

0 summaries processed

No automatically processable data submitted

Flammability

Flammability

This section summarises the flammability values from all registered dossiers for the substance.

More information on processable studies and data-waiving is available in the section help of the ‘Scientific properties’ header.

Study results

If more than one value is available, results are displayed as concatenated distinct values, ordered by most to least commonly provided, with the % of provided values appended. The % is based on count of values provided.

Substances or mixtures which in contact with water release flammable gases which may ignite spontaneously (Cat.1)

Flammable aerosols (Cat.2)

Flammable gases (Cat.2)

Flammable solids (Cat.2)

Self-heating substances and mixtures (Cat.2)

Substances or mixtures which in contact with water release flammable gases which may ignite spontaneously (Cat.2)

Non-flammable aerosols (Cat.3)

Substances or mixtures which in contact with water releases flammable gases (Cat.3)

Chemically unstable gases (Cat.A)

Chemically unstable gases (Cat.B)

GHS criteria not met

Not classified based on GHS criteria

Extremely flammable

Extremely flammable liquefied gas

Substances and mixtures which in contact with water emit flammable gases

Contact with water liberates highly flammable gases

Highly flammable

Flammable

Pyrophoric

Spontaneously flammable in air (pyrophoric)

Non–flammable

Non flammable (based on GHS criteria)

No information available

Not classified

Note: Registrants can also select ‘other’ as the flammability value for their substance. If so, the data provided is not processed for the Brief Profile.

Summary

Registrants can register their substance’s flammability as:

Extremely flammable

Extremely flammable liquefied gas

Contact with water liberates highly flammable gases

Highly flammable

Flammable

Spontaneously flammable in air (pyrophoric)

Non–flammable

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications.

Study results

15 studies submitted

0 studies processed

No automatically processable data submitted

Type of Study provided

Studies with data

Key study

3

Supporting study

12

Weight of evidence

Other

Data waiving

no waivers

Summaries

2 summaries submitted

0 summaries processed

No automatically processable data submitted

Explosiveness

Explosiveness

This section summarises the explosiveness values from all registered dossiers for the substance.

More information on processable studies and data-waiving is available in the section help of the ‘Scientific properties’ header.

Study results

If more than one value is available, results are displayed as concatenated distinct values, ordered by most to least commonly provided, with the % of provided values appended. The % is based on count of values provided.

Summary

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications.

Study results

3 studies submitted

0 studies processed

No automatically processable data submitted

Type of Study provided

Studies with data

Key study

Supporting study

Weight of evidence

Other

Data waiving

Not feasible

Sci. unjustified

Exposure cons.

Other

3

Summaries

0 summaries submitted

0 summaries processed

No data available

Oxidising

Oxidising

This section summarises the oxidising values from all registered dossiers for the substance.

More information on processable studies and data-waiving is available in the section help of the ‘Scientific properties’ header.

Study results

If more than one value is available, results are displayed as concatenated distinct values, ordered by most to least commonly provided, with the % of provided values appended. The % is based on count of values provided.

Summary

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications.

Study results

3 studies submitted

0 studies processed

No automatically processable data submitted

Type of Study provided

Studies with data

Key study

Supporting study

Weight of evidence

Other

Data waiving

Not feasible

Sci. unjustified

Exposure cons.

Other

3

Summaries

0 summaries submitted

0 summaries processed

No data available

Oxidation reduction potential

Oxidation reduction potential

This section summarises the oxidation reduction potential values from all registered dossiers for the substance.

More information on processable studies and data-waiving is available in the section help of the ‘Scientific properties’ header.

Study results

If more than one numerical result is available per endpoint, the range of results (min-max) and range of experimental conditions will be presented (RANGE method).

Oxidation reduction potential in mV provides substance information on the substance’s oxidation reduction measured in millivolts at a temperature measured in °C.

Summary

Oxidation reduction potential in mV at 20°C provides substance information on the substance’s oxidation reduction measured in millivolts at a temperature of 20°C.

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications.

Data not provided by the registrant

pH

pH

This section summarises the pH values from all registered dossiers for the substance.

More information on processable studies and data-waiving is available in the section help of the ‘Scientific properties’ header.

Study results

If more than one numerical result is available per endpoint, the range of results (min-max) and range of experimental conditions will be presented (RANGE method).

pH provides substance information on the substance’s acidity level measured in pH at a temperature measured in °C and a concentration measured in (milli)grams per litre.

Note: Results without a concentration value are not processed for the Brief Profile.

Summary

For this endpoint registrants do not provide summary data.

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications.

Data not provided by the registrant

Dissociation constant

Dissociation constant

This section summarises the dissociating values from all registered dossiers for the substance.

More information on processable studies and data-waiving is available in the section help of the ‘Scientific properties’ header.

Study results

If more than one picklist value is available per endpoint, results are displayed as concatenated distinct values, ordered by most to least commonly provided, with the % of provided values appended. The % is based on count of values provided.

If more than one numerical result is available per endpoint, the range of results (min-max) and range of experimental conditions will be presented (RANGE method).

Summary

pKa at 20°C provides numerical substance information on the dissociation constant in pKa at a temperature of 20°C.

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications.

Study results

3 studies submitted

0 studies processed

No automatically processable data submitted

Type of Study provided

Studies with data

Key study

Supporting study

Weight of evidence

Other

Data waiving

Not feasible

Sci. unjustified

Exposure cons.

Other

3

Summaries

0 summaries submitted

0 summaries processed

No data available

Viscosity

Viscosity

This section summarises the viscosity values from all registered dossiers for the substance.

More information on processable studies and data-waiving is available in the section help of the ‘Scientific properties’ header.

Study results

If more than one numerical result is available per endpoint, the range of results (min–max) and range of experimental conditions will be presented (RANGE method).

Registrants can report substance information on viscosity as:

Dynamic viscosity (in mPa s)

Kinematic viscosity (in mm²)/s)

Flow time (in s) – ASTM Cup 1

Flow time (in s) – ASTM Cup 2

Flow time (in s) – ASTM Cup 3

Flow time (in s) – ASTM Cup 4

Flow time (in s) – 3 mm ISO cup

Flow time (in s) – 4 mm ISO cup

Flow time (in s) – 5 mm ISO cup

Flow time (in s) – 6 mm ISO cup

Flow time (in s) – other:

Summary

Static viscosityat 20°C provides substance information on the substance’s (static) viscosity per square millimetre per second at a temperature of 20°C.

Dynamic viscosityat 20°C provides substance information on the substance’s (dynamic) viscosity per millipascal second at a temperature of 20°C.

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications.

Study results

15 studies submitted

3 studies processed

R dynamic viscosity (in mPa s)

0.3 [3]

Type of Study provided

Studies with data

Key study

3

Supporting study

12

Weight of evidence

Other

Data waiving

no waivers

Summaries

2 summaries submitted

0 summaries processed

No automatically processable data submitted

Environmental fate and pathways

Environmental fate and pathwaysThis section provides environmental fate and pathways information compiled from all registered dossiers for the substance.

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Phototransformation in air

This section summarises the values related to phototransformation in air from all registered dossiers for the substance.

More information on processable studies and data-waiving is available in the section help of the ‘Scientific properties’ header.

Study results

If more than one numerical result is available per endpoint, the range of results (min-max, RANGE method) will be displayed.

Dissipation half-life provides substance information on the substance’s dissipation half-life for the parent compound per second/minute/hour/day/week/month/year.

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications.

Data not provided by the registrant

Hydrolysis

Hydrolysis

This section summarises the values related to hydrolysis from all registered dossiers for the substance.

More information on processable studies and data-waiving is available in the section help of the ‘Scientific properties’ header.

Study results

For this endpoint registrants do not provide study results that are processable for the Brief Profile.

Summary

Half-life for hydrolysis provides substance information on the substance’s half-life for hydrolysis in seconds/minutes/hours/days/weeks/months/years at a temperature measured in °C.Note: Results without a measurement condition (temperature) are not processed for the Brief Profile.

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications.

Study results

3 studies submitted

0 studies processed

Study data not processed for brief profile

Type of Study provided

Studies with data

Key study

Supporting study

Weight of evidence

Other

Data waiving

Not feasible

Sci. unjustified

Exposure cons.

Other

3

Summaries

0 summaries submitted

0 summaries processed

No data available

Phototransformation in water

Phototransformation in water

This section summarises the values related to phototransformation in water from all registered dossiers for the substance.

More information on processable studies and data-waiving is available in the section help of the ‘Scientific properties’ header.

Study results

If more than one numerical result is available per endpoint, the range of results (min-max) and range of experimental conditions will be presented (RANGE method).

Dissipation Half-life of parent compound provides substance information on the substance’s dissipation half-life for the parent compound per second/minute/hour/day/week/month/year.

Summary

Phototransformation in water provides information on the substance’s phototransformation in water in seconds/minutes/hours/days/weeks/months/years.

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications.

Study results

3 studies submitted

0 studies processed

No automatically processable data submitted

Type of Study provided

Studies with data

Key study

Supporting study

Weight of evidence

Other

Data waiving

Not feasible

Sci. unjustified

3

Exposure cons.

Other

Summaries

2 summaries submitted

0 summaries processed

No automatically processable data submitted

Phototransformation in soil

Phototransformation in soil

This section summarises the values related to phototransformation in soil from all registered dossiers for the substance.

More information on processable studies and data-waiving is available in the section help of the ‘Scientific properties’ header.

Study results

If more than one numerical result is available per endpoint, the range of results (min-max) and range of experimental conditions will be presented (RANGE method).

Dissipation Half-life of parent compound provides substance information on the substance’s dissipation half-life for the parent compound per second/minute/hour/day/week/month/year.

Summary

Phototransformation in soil provides substance information on the substance’s phototransformation in soil in seconds/minutes/hours/days/weeks/months/years.

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications.

Study results

3 studies submitted

0 studies processed

No automatically processable data submitted

Type of Study provided

Studies with data

Key study

Supporting study

Weight of evidence

Other

Data waiving

Not feasible

Sci. unjustified

3

Exposure cons.

Other

Summaries

2 summaries submitted

0 summaries processed

No automatically processable data submitted

Biodegradation in water - screening tests

Biodegradation in water - screening tests

This section summarises the values related to the screening tests for biodegradation in water from all registered dossiers for the substance.

More information on processable studies and data-waiving is available in the section help of the ‘Scientific properties’ header.

Study results

If more than one numerical result is available per endpoint, the range of results (min-max) and range of experimental conditions will be presented (RANGE method).

If more than one picklist value is available per endpoint, results are displayed as concatenated distinct values, ordered by most to least commonly provided, with the % of provided values appended. The % is based on count of values provided.

Note: Registrants can also select ‘other’ as the unit of measure. If so, the data provided is not processed for the Brief Profile.

Applicant’s summary and conclusion –Interpretation of results provides information on the substance’s biodegradation properties in water and can be registered by the registrants by one or more of the following picklist options:

Readily biodegradable

Readily biodegradable but failing the 10-day window

Inherently biodegradable

Inherently biodegradable, fulfilling specific criteria;

Inherently biodegradable, not fulfilling specific criteria

Not inherently biodegradable

Not readily biodegradable

Under test conditions no biodegradation observed

Note: Registrants can also select ‘other’ as picklist option for describing the biodegradation values of the substance in water. If so, the data provided is not processed in the Brief Profile.

Summary

Biodegradation in water provides information on the substance’s biodegradation properties in water and can be registered by the registrants by one or more of the following picklist options:

Readily biodegradable

Readily biodegradable but failing the 10-day window

Inherently biodegradable

Inherently biodegradable, fulfilling specific criteria;

Inherently biodegradable, not fulfilling specific criteria

Under test conditions no biodegradation observed

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications.

Study results

4 studies submitted

2 studies processed

C Interpretation of results

Readily biodegradable (100%) [2]

Type of Study provided

Studies with data

Key study

2

Supporting study

2

Weight of evidence

Other

Data waiving

no waivers

Summaries

2 summaries submitted

0 summaries processed

No automatically processable data submitted

Biodegradation in water & sediment - simulation tests

Biodegradation in water & sediment - simulation tests

This section summarises the values related to the simulation tests for biodegradation in water and sediments from all registered dossiers for the substance.

More information on processable studies and data-waiving is available in the section help of the ‘Scientific properties’ header.

Study results

For this endpoint registrants do not provide study results that are processable for the Brief Profile.

Summary data

If more than one numerical result is available per endpoint, the range of results (min-max) and range of experimental conditions will be presented (RANGE method).

Half-life in water provides substance information on the substance’s half-life in water in seconds/minutes/hours/days/weeks/months/years at a temperature measured in °C.

Note: If a temperature value is not provided by the registrant, the information on half-life in water will not be processed for the Brief Profiles.

Half-life in sediment provides substance information on the substance’s half-life in sediment in seconds/minutes/hours/days/weeks/months/years at a temperature measured in °C.Note: Results without a measurement condition (temperature) are not processed for the Brief Profile.

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications.

Data not provided by the registrant

Biodegradation in soil

Biodegradation in soil

This section summarises the values related to biodegradation in soil from all registered dossiers for the substance.

More information on processable studies and data-waiving is available in the section help of the ‘Scientific properties’ header.

Study results

For this endpoint registrants do not provide study results that are processable for the Brief Profile.

Summary data

If more than one numerical result is available per endpoint, the range of results (min-max) and range of experimental conditions will be presented (RANGE method).

Half-life in soil provides substance information on the substance’s half-life in water in seconds/minutes/hours/days/weeks/months/years at a temperature measured in °C.

Note: Results without a measurement condition (temperature) are not processed for the Brief Profile.

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications.

Study results

2 studies submitted

0 studies processed

Study data not processed for brief profile

Type of Study provided

Studies with data

Key study

Supporting study

Weight of evidence

Other

Data waiving

Not feasible

Sci. unjustified

Exposure cons.

Other

2

Summaries

0 summaries submitted

0 summaries processed

No data available

Bioaccumulation: aquatic / sediment

Bioaccumulation: aquatic / sediment

This section summarises the values related to aquatic/sediment bioaccumulation in all registered dossiers for the substance.

More information on processable studies and data-waiving is available in the section help of the ‘Scientific properties’ header.

Study results

For this endpoint registrants do not provide study results that are processable for the Brief Profile.

Summary data

If more than one numerical result is available per endpoint, the range of results (min-max) and range of experimental conditions will be presented (RANGE method).

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications.

Study results

2 studies submitted

0 studies processed

No automatically processable data submitted

Type of Study provided

Studies with data

Key study

2

Supporting study

Weight of evidence

Other

Data waiving

no waivers

R Summaries

2 summaries submitted

2 summaries processed

Koc at 20°C

2 187.76

Henrys law constant (H)

Henrys law constant (H)

This section summarises the values related to Henry’s law constant (H) from all registered dossiers for the substance.

More information on processable studies and data-waiving is available in the section help of the ‘Scientific properties’ header.

Study results

If more than one numerical result is available per endpoint, the range of results (min-max) and range of experimental conditions will be presented (RANGE method).

Henry’s law constant can be presented as different types, depending on the units chosen:

H dimensionless provides substance information on the substance’s Henry’s Law Constant (dimensionless) at a temperature measured in °C and a pressure measured in Pascal.

H dimensionless volumetric basis provides substance information on the substance’s Henry’s Law Constant in dimensionless volumetric basis at a temperature measured in °C and a pressure measured in Pascal.

H atm provides substance information on the substance’s Henry’s Law Constant in atm at temperature measured in °C and a pressure measured in Pascal.

H atm m3/mol provides substance information on the substance’s Henry’s Law Constant in atm m3/mol at a temperature measured in °C and a pressure measured in Pascal.

H Pa m3/mol provides substance information on the substance’s Henry’s Law Constant in Pa m3/mol at a temperature measured in °C and the atmospheric pressure measured in Pascal.

Note: Registrants can also select ‘other’ as the type of Henry’s law constant. If so, the data provided is not processed for the Brief Profile.

Summary

Henry’s Law Constant provides substance information on the substance’s Henry’s Law Constant measured in in Pa.m3.mol-1 at a temperature measured in °C.

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications.

Data not provided by the registrant

Distribution modelling

Distribution modelling

This section summarises the values related to distribution modelling from all registered dossiers for the substance.

More information on processable studies and data-waiving is available in the section help of the ‘Scientific properties’ header.

Study results

Displayed are the RANGES of min – max of values (provided in %).

Percentage distribution in the Media displays the values attributed by the registrants to the following options:

air

water

soil

sediment

suspended sediment

biota

aerosol

Summary

For this endpoint registrants do not provide summaries that are processable for the Brief Profile.Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications.

Study results

2 studies submitted

2 studies processed

% Distribution in Media:

R Air

91.6 % [2]

R Water

4.9 % [2]

R Soil

0.7 % [2]

R Sediment

2.1 % [2]

R Suspended sediment

0 % [2]

R Biota

0 % [2]

Type of Study provided

Studies with data

Key study

2

Supporting study

Weight of evidence

Other

Data waiving

no waivers

No summary exists for this scientific endpoint

Ecotoxicological information

Ecotoxicological informationThis section summarises the Ecotoxicological information provided from all registered dossiers for the substance.

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

Predicted No-Effect Concentration (PNEC)

If more than one numerical result is available per endpoint, the range of results (min-max) will be presented (RANGE method).

Summaries

Short–term toxicity to fish

This section summarises the values related to short–term toxicity to fish from all registered dossiers for the substance.

More information on processable studies and data-waiving is available in the section help of the ‘Scientific properties’ header.

Study results

Displayed are the RANGES of min – max of the PRIORITISED value(s) within the five highest priority groupings of provided data. Data is generally standardised and displayed in milligram per litre or molar per litre.

The availability of additional data beyond the five results displayed is indicated by (…).

Processable data is prioritised by the toxicity descriptor type (see list below) and subsequently further prioritised by duration (longer prioritised over shorter). The five highest priority groupings of provided data are displayed in milligram per litre or molar per litre.

Prioritisation by dose descriptor:

LC50

LC0

LC100

LC10

EC50

EC0

EC100

EC10

NOEC

LOEC

LL50

LL0

LL100

LL10

EL50

EL0

EL100

EL10

IC50

IC10

IC100

NOELR

LOELR

Note: Registrants can also select ‘other’ as the dose descriptor type or unit of measure. If so, the data provided is not processed for the Brief Profile.

Summary

LC50 for freshwater fish provides substance information on the substance’s lethal concentration for 50% of the freshwater fish in the test, displayed in milligram per litre.

LC50 for marine water fish provides substance information on the substance’s lethal concentration for 50% of the marine water fish in the test, displayed in milligram per litre.

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications.

Study results

10 studies submitted

2 studies processed

P/RResults

LL50 (4 days) 12.51 mg/L [2]

Type of Study provided

Studies with data

Key study

2

Supporting study

2

6

Weight of evidence

Other

Data waiving

no waivers

Summaries

2 summaries submitted

0 summaries processed

No automatically processable data submitted

Long–term toxicity to fish

Long–term toxicity to fish

This section summarises the values related to long term toxicity to fish from all registered dossiers for the substance.

More information on processable studies and data-waiving is available in the section help of the ‘Scientific properties’ header.

Study results

Displayed are the RANGES of min – max of the PRIORITISED value(s) within the five highest priority groupings of provided data. Data is generally standardised and displayed in milligram per litre or molar per litre.

The availability of additional data beyond the five results displayed is indicated by (…).

Processable data is prioritised by the toxicity descriptor type (see list below) and subsequently further prioritised by duration (longer prioritised over shorter).

Prioritisation by dose descriptor:

NOEC

LOEC

EC10

LC10

IC10

EC50

LC50

IC50

EL10

EL50

LL10

LL50

NOELR

LOELR

Note: Registrants can also select ‘other’ as the dose descriptor type or unit of measure. If so, the data provided is not processed for the Brief Profile.

Summary

EC10 / LC10 or NOEC for freshwater fish provides substance information on the substance’s effect concentration/lethal concentration for 10% of the tested freshwater fish or the no observed effect concentration. Values are displayed in milligram per litre.

EC10 / LC10 or NOEC for marine fish provides substance information on the substance’s effect concentration/lethal concentration for 10% of the tested freshwater fish or the no observed effect concentration. Values are displayed in milligram per litre.

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications.

Study results

8 studies submitted

2 studies processed

P/RResults

NOELR (28 days) 2.8 mg/L [2]

Type of Study provided

Studies with data

Key study

2

Supporting study

6

Weight of evidence

Other

Data waiving

no waivers

Summaries

2 summaries submitted

0 summaries processed

No automatically processable data submitted

Short–term toxicity to aquatic invertebrates

Short–term toxicity to aquatic invertebrates

This section summarises the values related to short term toxicity to aquatic invertebrates from all registered dossiers for the substance.

More information on processable studies and data-waiving is available in the section help of the ‘Scientific properties’ header.

Study results

Displayed are the RANGES of min – max of the PRIORITISED value(s) within the five highest priority groupings of provided data. Data is generally standardised and displayed in milligram per litre or molar per litre.

The availability of additional data beyond the five results displayed is indicated by (…).

Processable data is prioritised by the toxicity descriptor type (see list below) and subsequently further prioritised by duration (longer prioritised over shorter).

Prioritisation by dose descriptor:

EC50

IC50

LC50

EC0

LC0

EC100

LC100

LC10

EC10

NOEC

LOEC

LL50

LL0

LL100

LL10

EL50

EL0

EL100

EL10

IC10

IC100

NOELR

LOELR

Note: Registrants can also select ‘other’ as the dose descriptor type or unit of measure. If so, the data provided is not processed for the Brief Profile.

Summary

LC50 for freshwater invertebrates provides substance information on the substance’s lethal concentration for 50% of the freshwater invertebrates in the test, displayed in milligram per litre.

LC50 for marine water invertebrates provides substance information on the substance’s lethal concentration for 50% of the marine water invertebrates in the test, displayed in milligram per litre.

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications.

Study results

10 studies submitted

2 studies processed

P/RResults

EL50 (48 h) 21.85 mg/L [2]

Type of Study provided

Studies with data

Key study

2

Supporting study

2

6

Weight of evidence

Other

Data waiving

no waivers

Summaries

2 summaries submitted

0 summaries processed

No automatically processable data submitted

Long–term toxicity to aquatic invertebrates

Long–term toxicity to aquatic invertebrates

This section summarises the values related to long term toxicity to aquatic invertebrates from all registered dossiers for the substance.

More information on processable studies and data-waiving is available in the section help of the ‘Scientific properties’ header.

Study results

Displayed are the RANGES of min – max of the PRIORITISED value(s) within the five highest priority groupings of provided data. Data is generally standardised and displayed in milligram per litre or molar per litre.

The availability of additional data beyond the five results displayed is indicated by (…).

Processable data is prioritised by the toxicity descriptor type (see list below) and subsequently further prioritised by duration (longer prioritised over shorter).

Prioritisation by dose descriptor:

NOEC

LOEC

EC10

LC10

IC10

EC50

LC50

IC50

EL10

EL50

LL10

LL50

NOELR

LOELR

Note: Registrants can also select ‘other’ as the dose descriptor type or unit of measure. If so, the data provided is not processed for the Brief Profile.

Summary

EC10 / LC10 or NOEC for freshwater invertebrates provides substance information on the substance’s effect concentration/lethal concentration for 10% of the tested freshwater invertebrates or the no observed effect concentration for freshwater invertebrates. Values are presented in (nano/ micro/milli)gram per litre and/or (nano/ micro/milli)molar per litre.

EC10 / LC10 or NOEC for marine water invertebrates provides substance information on the substance’s effect concentration/lethal concentration for 10% of the tested marine water invertebrates or the no observed effect concentration for marine water invertebrates. Values are presented in (nano/ micro/milli)gram per litre and/or (nano/ micro/milli)molar per litre.

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications.

Study results

8 studies submitted

2 studies processed

P/RResults

NOELR (21 days) 4.888 mg/L [2]

Type of Study provided

Studies with data

Key study

2

Supporting study

6

Weight of evidence

Other

Data waiving

no waivers

Summaries

2 summaries submitted

0 summaries processed

No automatically processable data submitted

Toxicity to aquatic algae and cyanobacteria

Toxicity to aquatic algae and cyanobacteria

This section summarises the values related to toxicity to aquatic algae and cyanobacteria from all registered dossiers for the substance.

More information on processable studies and data-waiving is available in the section help of the ‘Scientific properties’ header.

Study results

Displayed are the RANGES of min – max of the PRIORITISED value(s) within the five highest priority groupings of provided data. Data is generally standardised and displayed in milligram per litre or molar per litre.

The availability of additional data beyond the five results displayed is indicated by (…).

Processable data is prioritised by the toxicity descriptor type (see list below) and subsequently further prioritised by duration (longer prioritised over shorter).

Prioritisation by dose descriptor:

EC50

IC50

NOEC

LOEC

EC10

IC10

EC20

EC5

EC0

EC100

IC100

EC90

EL0

EL5

EL10

EL20

EL50

EL90

EL100

NOELR

LOELR

Note: Registrants can also select ‘other’ as the dose descriptor type or unit of measure. If so, the data provided is not processed for the Brief Profile.

Summary

LC50 for freshwater algae provides substance information on the substance’s lethal concentration for 50% of the freshwater algae in the test, displayed in generally milligram per litre.

LC50 for marine water algae provides substance information on the substance’s lethal concentration for 50% of the marine water algae in the test, generally displayed in milligram per litre.

EC10 / LC10 or NOEC for freshwater algae provides substance information on the substance’s effect concentration/lethal concentration for 10% of the tested freshwater algea or the no observed effect concentration for freshwater algae. Values are generally displayed in milligram per litre.

EC10 / LC10 or NOEC for marine water algae provides substance information on the substance’s effect concentration/lethal concentration for 10% of the tested marine water algae or the no observed effect concentration for marine water algae. Values are generally displayed in milligram per litre.

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications.

Study results

20 studies submitted

4 studies processed

P/RResults

EL50 (72 h) 9.285 mg/L [2]

NOELR (72 h) 2.077 mg/L [2]

Type of Study provided

Studies with data

Key study

4

Supporting study

2

14

Weight of evidence

Other

Data waiving

no waivers

Summaries

2 summaries submitted

0 summaries processed

No automatically processable data submitted

Toxicity to aquatic plants other than algae

Toxicity to aquatic plants other than algae

This section summarises the values related to toxicity to aquatic plants (other than algae) from all registered dossiers for the substance.

More information on processable studies and data-waiving is available in the section help of the ‘Scientific properties’ header.

Study results

Displayed are the RANGES of min – max of the PRIORITISED value(s) within the five highest priority groupings of provided data. Data is generally standardised and the displayed in milligram per litre or molar per litre.

The availability of additional data beyond the five results displayed is indicated by (…).

Processable data is prioritised by the toxicity descriptor type (see list below) and subsequently further prioritised by duration (longer prioritised over shorter).

Prioritisation by dose descriptor:

EC50

IC50

NOEC

LOEC

EC10

IC10

EC20

EC5

EC0

EC100

IC100

EC90

EL0

EL5

EL10

EL20

EL50

EL90

EL100

NOELR

LOELR

Note: Registrants can also select ‘other’ as the dose descriptor type or unit of measure. If so, the data provided is not processed for the Brief Profile.

Summary

EC/LC50 for freshwater plants provides substance information on the substance’s effect concentration or lethal concentration for 50% of the freshwater plants in the test, generally displayed in milligram per litre.

EC50/LC50 for marine water plants provides substance information on the substance’s effect concentration or lethal concentration for 50% of the marine water algae in the test, generally displayed in milligram per litre.

EC10 / LC10 or NOEC for freshwater plants provides substance information on the substance’s effect concentration/lethal concentration for 10% of the tested freshwater plants or the no observed effect concentration for freshwater plants. Values are generally displayed in milligram per litre.

EC10 / LC10 or NOEC for marine water plants provides substance information on the substance’s effect concentration/lethal concentration for 10% of the tested marine water plants or the no observed effect concentration for marine water plants. Values are generally displayed in milligram per litre.

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications.

Data not provided by the registrant

Toxicity to microorganisms

Toxicity to microorganisms

This section summarises the values related to toxicity to microorganisms from all registered dossiers for the substance.

More information on processable studies and data-waiving is available in the section help of the ‘Scientific properties’ header.

Study results

Displayed are the RANGES of min – max of the PRIORITISED value(s) within the five highest priority groupings of provided data. Data is generally displayed in milligram per litre or molar per litre.

The availability of additional data beyond the five results displayed is indicated by (…).

Processable data is prioritised by the toxicity descriptor type (see list below) and subsequently further prioritised by duration (longer prioritised over shorter).

Prioritisation by dose descriptor:

EC50

IC50

NOEC

LOEC

EC10

IC10

EC0

IC0

EC100

IC100

Note: Registrants can also select ‘other’ as the dose descriptor type or unit of measure. If so, the data provided is not processed for the Brief Profile.

Summary

EC50/LC50 for microorganisms provides substance information on the substance’s effect concentration or lethal concentration for 50% of the microorganisms in the test, generally displayed in milligram per litre.

EC10 / LC10 or NOEC for microorganisms provides substance information on the substance’s effect concentration/lethal concentration for 10% of the tested microorganisms or the no observed effect concentration for microorganisms. Values are generally displayed in milligram per litre.

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications.

Study results

16 studies submitted

0 studies processed

No automatically processable data submitted

Type of Study provided

Studies with data

Key study

4

Supporting study

12

Weight of evidence

Other

Data waiving

no waivers

Summaries

2 summaries submitted

0 summaries processed

No automatically processable data submitted

Sediment toxicity

Sediment toxicity

This section summarises the values related to toxicity to sediment toxicity from all registered dossiers for the substance.

More information on processable studies and data-waiving is available in the section help of the ‘Scientific properties’ header.

Study results

Displayed are the RANGES of min – max of the PRIORITISED value(s) within the five highest priority groupings of provided data. Data is generally displayed in milligrams per kilogram sediment (dry weight) or in milligram per litre.

Note: Registrants can also select ‘other’ as the dose descriptor type or unit of measure. If so, the data provided is not processed for the Brief Profile.

Summary

EC/LC50 for freshwater sediment provides substance information on the substance’s effect concentration or lethal concentration for 50% of the model organisms feeding off the freshwater sediment, generally displayed in milligrams per kilogram sediment (dry weight).

EC50/LC50 for marine sediment provides substance information on the substance’s effect concentration or lethal concentration for 50% of the model organisms feeding off the marine sediment, generally displayed in milligrams per kilogram sediment (dry weight).

EC10 / LC10 or NOEC for freshwater sediment provides substance information on the substance’s effect concentration/lethal concentration for 10% of the model organisms feeding off the freshwater sediment or the no observed effect concentration for of the model organisms feeding off the freshwater sediment. Values are generally displayed in milligrams per kilogram (dry weight).

EC10 / LC10 or NOEC for marine sediment provides substance information on the substance’s effect concentration/lethal concentration for 10% of the model organisms feeding off the marine sediment or the no observed effect concentration for of the model organisms feeding off the marine sediment. Values are generally displayed in milligrams per kilogram (dry weight).

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications.

Study results

2 studies submitted

0 studies processed

No automatically processable data submitted

Type of Study provided

Studies with data

Key study

Supporting study

Weight of evidence

Other

Data waiving

Not feasible

Sci. unjustified

Exposure cons.

Other

2

Summaries

0 summaries submitted

0 summaries processed

No data available

Endocrine disrupter testing in aquatic vertebrates – in vivo

Endocrine disruptor testing in aquatic vertebrates - in vivo

This section summarises the values related to endocrine disrupter testing in aquatic vertebrates from all registered dossiers for the substance.

More information on processable studies and data-waiving is available in the section help of the ‘Scientific properties’ header.

Study results

Displayed are the RANGES of min – max of the PRIORITISED value(s) within the five highest priority groupings of provided data. Data is generally displayed in milligrams per litre.

The availability of additional data beyond the five results displayed is indicated by (…).

Processable data is prioritised by the toxicity descriptor type (see list below) and subsequently further prioritised by duration (longer prioritised over shorter).

Prioritisation by dose descriptor:

NOEC

LOEC

EC10

LC10

IC10

EC50

LC50

IC50

EL10

EL50

LL10

LL50

NOELR

LOELR

Note: Registrants can also select ‘other’ as the dose descriptor type or unit of measure. If so, the data provided is not processed for the Brief Profile.

Summary

EC10 / LC10 or NOEC for freshwater fish provides substance information on the substance’s effect concentration/lethal concentration for 10% of the tested freshwater fish or the no observed effect concentration. Values are displayed in milligram per litre.

EC10 / LC10 or NOEC for marine fish provides substance information on the substance’s effect concentration/lethal concentration for 10% of the tested freshwater fish or the no observed effect concentration. Values are displayed in milligram per litre.

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications.

Data not provided by the registrant

Toxicity to terrestrial macroorganisms except arthropods

Toxicity to terrestrial macroorganisms except arthropods

This section summarises the values related to toxicity to soil macroorganisms (except arthropods) from all registered dossiers for the substance.

More information on processable studies and data-waiving is available in the section help of the ‘Scientific properties’ header.

Study results

Displayed are the RANGES of min – max of the PRIORITISED value(s) within the five highest priority groupings of provided data. Data is generally displayed in milligrams per kilogram in the case of soil (dry/wet weight) or gram per hectare.

The availability of additional data beyond the five results displayed is indicated by (…).

Processable data is prioritised by the toxicity descriptor type (see list below) and subsequently further prioritised by duration (in hours, longer prioritised over shorter). Thirdly the display of data is prioritised by units.

Prioritisation by dose descriptor:

NOEC

LOEC

EC10

LC10

LD10

EC50

LC50

LD50

EC0

LC0

LD0

EC100

LC100

LD100

LR10

LR50

LR0

LR100

Prioritisation by units (dry weight):

Mg/cm2

g/ha

Note: Registrants can also select ‘other’ as the dose descriptor type or unit of measure. If so, the data provided is not processed for the Brief Profile.

Summary

EC/LC50 for freshwater sediment provides substance information on the substance’s effect concentration or lethal concentration for 50% of the model organisms feeding off the freshwater sediment, generally displayed in milligrams per kilogram (dry weight).

EC50/LC50 for marine sediment provides substance information on the substance’s effect concentration or lethal concentration for 50% of the model organisms feeding off the marine sediment, generally displayed in milligrams per kilogram (dry weight).

EC10 / LC10 or NOEC for freshwater sediment provides substance information on the substance’s effect concentration/lethal concentration for 10% of the model organisms feeding off the freshwater sediment or the no observed effect concentration for of the model organisms feeding off the freshwater sediment. Values are generally displayed in milligrams per kilogram (dry weight).

EC10 / LC10 or NOEC for marine sediment provides substance information on the substance’s effect concentration/lethal concentration for 10% of the model organisms feeding off the marine sediment or the no observed effect concentration for of the model organisms feeding off the marine sediment. . Values are generally displayed in measured in (nano/ micro/milli)gram per kilogram (dry weight).

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications.

Study results

2 studies submitted

0 studies processed

No automatically processable data submitted

Type of Study provided

Studies with data

Key study

Supporting study

Weight of evidence

Other

Data waiving

Not feasible

Sci. unjustified

Exposure cons.

Other

2

Summaries

0 summaries submitted

0 summaries processed

No data available

Toxicity to terrestrial arthropods

Toxicity to terrestrial arthropods

This section summarises the values related to toxicity to (terrestrial) arthropods from all registered dossiers for the substance.

More information on processable studies and data-waiving is available in the section help of the ‘Scientific properties’ header.

Study results

Displayed are the RANGES of min – max of the PRIORITISED value(s) within the five highest priority groupings of provided data. Data is generally displayed in milligrams per kilogram in the case of soil (dry/wet weight), or gram per hectare. Otherwise data is displayed reported as provided by the registrant(s).

The availability of additional data beyond the five results displayed is indicated by (…).

Processable data is prioritised by the toxicity descriptor type (see list below) and subsequently further prioritised by duration (longer prioritised over shorter). Thirdly the display of data is prioritised by unit.

Prioritisation by dose descriptor:

NOEC

LOEC

EC10

LC10

LD10

EC50

LC50

LD50

EC0

LC0

LD0

EC100

LC100

LD100

LR10

LR50

LR0

LR100

Prioritisation by unit:

soil dw (g/ha and mg/cm²)

soil ww; (g/ha and mg/cm²)

µg per animal

mL/ha; mg/kg bw

mg/kg diet

ppm

mg/kg dung dw

Note: Registrants can also select ‘other’ as the dose descriptor type or unit of measure. If so, the data provided is not processed for the Brief Profile.

Summary

Short-term EC50 or LC50 for soil dwelling arthropods provides substance information on the substance’s effect concentration or lethal concentration (short term) for 50% of the soil dwelling arthropods in the test, generally displayed in milligram per kilo soil (dry weight).

Long-term EC10 or LC10 or NOEC for soil dwelling arthropods provides substance information on the substance’s effect concentration or lethal concentration (long term) for 10% of the soil dwelling arthropods in the test, or the no observed effect concentration for soil dwelling arthropods. Values are generally displayed in milligram per kilo soil (dry weight).

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications.

Study results

2 studies submitted

0 studies processed

No automatically processable data submitted

Type of Study provided

Studies with data

Key study

Supporting study

Weight of evidence

Other

Data waiving

Not feasible

Sci. unjustified

Exposure cons.

Other

2

Summaries

0 summaries submitted

0 summaries processed

No data available

Toxicity to terrestrial plants

Toxicity to terrestrial plants

This section summarises the values related to toxicity to (terrestrial) plants from all registered dossiers for the substance.

If more than one numerical result is available per endpoint, the range of results (min-max) and range of experimental conditions will be presented (RANGE method).

More information on processable studies and data-waiving is available in the section help of the ‘Scientific properties’ header.

Study results

Displayed are the RANGES of min – max of the PRIORITISED value(s) within the five highest priority groupings of provided data. Data is generally displayed in milligrams per kilogram in the case of soil (dry/wet weight), or gram per hectare. Otherwise data is displayed reported as provided by the registrant(s).The availability of additional data beyond the five results displayed is indicated by (…).

Processable data is prioritised by the toxicity descriptor type (see list below) and subsequently further prioritised by duration (longer prioritised over shorter). Thirdly the display of data is prioritised by units.

Prioritisation by dose descriptor:

NOEC

LOEC

EC10

LC10

EC50

LC50

EC0

EC25

EC100

LC0

LC25

LC100

ER0

ER10

ER25

ER50

ER100

Prioritisation by units:

soil dw (g/ha, kg/ha and lbs/acre).

soil ww (g/ha, kg/ha and lbs/acre).

Note: Registrants can also select ‘other’ as the dose descriptor type or unit of measure. If so, the data provided is not processed for the Brief Profile.

Summary

Short-term EC50 or LC50 for terrestrial plants provides substance information on the substance’s effect concentration or lethal concentration (short term) for 50% of the terrestrial plants in the test, generally displayed in milligram per kilo soil (dry weight).

Long-term EC10 or LC10 or NOEC for terrestrial plants provides substance information on the substance’s effect concentration or lethal concentration (long term) for 10% of the terrestrial plants in the test, or the no observed effect concentration for terrestrial plants. Values are generally displayed in milligram per kilo soil (dry weight).

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications.

Study results

2 studies submitted

0 studies processed

No automatically processable data submitted

Type of Study provided

Studies with data

Key study

Supporting study

Weight of evidence

Other

Data waiving

Not feasible

Sci. unjustified

Exposure cons.

Other

2

Summaries

0 summaries submitted

0 summaries processed

No data available

Toxicity to soil microorganisms

Toxicity to soil microorganisms

This section summarises the values related to toxicity to soil microorganisms from all registered dossiers for the substance.

More information on processable studies and data-waiving is available in the section help of the ‘Scientific properties’ header.

Study results

Displayed are the RANGES of min – max of the PRIORITISED value(s) within the five highest priority groupings of provided data. Data is generally displayed in milligrams per kilogram in the case of soil (dry/wet weight), or gram per hectare. Otherwise data is displayed reported as provided by the registrant(s).

The availability of additional data beyond the five results displayed is indicated by (…).

Processable data is prioritised by the toxicity descriptor type (see list below) and subsequently further prioritised by duration (longer prioritised over shorter). Thirdly the display of data is prioritised by units.

Prioritisation by dose descriptor:

NOEC

EC10

EC25

EC50

EC100

EC0

ER0

ER10

ER25

ER50

ER100

Prioritisation by units:

Soil dw (g/ha, kg/ha and lbs/acre).

Soil ww (g/ha, kg/ha and lbs/acre).

Note: Registrants can also select ‘other’ as the dose descriptor type or unit of measure. If so, the data provided is not processed for the Brief Profile.

Summary

If more than one numerical result is available per endpoint, the range of results (min-max) and range of experimental conditions will be presented (RANGE method).

Long-term EC10 or LC10 or NOEC for soil microorganisms provides substance information on the substance’s effect concentration or lethal concentration (long term) for 10% of the soil microorganisms in the test, or the no observed effect concentration for soil microorganisms. Values are generally displayed in milligram per kilo soil (dry weight).

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications.

Study results

2 studies submitted

0 studies processed

No automatically processable data submitted

Type of Study provided

Studies with data

Key study

Supporting study

Weight of evidence

Other

Data waiving

Not feasible

Sci. unjustified

Exposure cons.

Other

2

Summaries

0 summaries submitted

0 summaries processed

No data available

Toxicity to birds

Toxicity to birds

This section summarises the values related to toxicity to birds from all registered dossiers for the substance.

More information on processable studies and data-waiving is available in the section help of the ‘Scientific properties’ header.

Study results

Displayed are the RANGES of min – max of the PRIORITISED value(s) within the five highest priority groupings of provided data. Data is generally displayed in milligrams per kilogram, per bodyweight per day. Otherwise data is displayed reported as provided by the registrant(s).The availability of additional data beyond the five results displayed is indicated by (…).

Processable data is prioritised by the toxicity descriptor type (see list below) and subsequently further prioritised by duration (longer prioritised over shorter). Thirdly the display of data is prioritised by units .

Prioritisation by dose descriptor type:

NOEC

LOEC

LC50

LD50

LOEC

LOEL

Prioritisation by unit:

bw/day (mg/kg bw/day; mg/kg bw/day; mg/kg bw/day)

mg/kg bw

mg/kg diet

mg/L drinking water.

Note: Registrants can also select ‘other’ as the dose descriptor type or unit of measure. If so, the data provided is not processed for the Brief Profile.

Summary

Short-term EC50 or LC50 for birds provides substance information on the substance’s effect concentration or lethal concentration (short term) for 50% of birds in the test, generally displayed in milligram per kilo food.

Long-term EC10 or LC10 or NOEC for birds provides substance information on the substance’s effect concentration or lethal concentration (long term) for 10% of the birds in the test, or the no observed effect concentration for birds. Values are generally displayed in milligram per kilo food.

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications.

Study results

2 studies submitted

0 studies processed

No automatically processable data submitted

Type of Study provided

Studies with data

Key study

Supporting study

Weight of evidence

Other

Data waiving

Not feasible

Sci. unjustified

Exposure cons.

Other

2

Summaries

0 summaries submitted

0 summaries processed

No data available

Toxicity to mammals

Toxicity to mammals

This section summarises the values related to toxicity to mammals (other above-ground organisms) from all registered dossiers for the substance.

More information on processable studies and data-waiving is available in the section help of the ‘Scientific properties’ header.

Study results

Displayed are the RANGES of min – max of the PRIORITISED value(s) within the five highest priority groupings of provided data. Data is generally displayed in milligrams per kilogram in the case of soil (dry/wet weight), or gram per hectare. Otherwise data is displayed as provided by the registrant(s).

The availability of additional data beyond the five results displayed is indicated by (…).Processable data is prioritised by the toxicity descriptor type (see list below) and subsequently further prioritised by duration (longer prioritised over shorter). Thirdly the display of data is prioritised by units.

Prioritisation by dose descriptor:

NOEC

EC50

LC50

LD50

EC100

LC100

LD100

EC0

LC0

LD0

LR50

LR0

LR100

ER50

ER0

ER100

Prioritisation by units

Soil dw (g/ha and mg/cm²)

Soil ww; (g/ha and mg/cm²)

µg per animal

mL/ha; mg/kg bw

mg/kg diet

ppm.

mg/kg dung dw

Note: Registrants can also select ‘other’ as the dose descriptor type or unit of measure. If so, the data provided is not processed for the Brief Profile.

Summary

Short-term EC50 or LC50 for mammals provides substance information on the substance’s effect concentration or lethal concentration (short term) for 50% of mammals in the test, generally displayed in milligram per kilo food.

Long-term EC10 or LC10 or NOEC for mammals provides substance information on the substance’s effect concentration or lethal concentration (long term) for 10% of the mammals in the test, or the no observed effect concentration for mammals. Values are generally displayed in milligram per kilo food.

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications.

Data not provided by the registrant

Toxicological information

Toxicological informationThis section summarises the Toxicological information provided from all registered dossiers for the substance. Please see the endpoint help sections for more specific information on the sections or see the ‘Scientific properties’ header for a more complete overview.

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

Derived No- or Minimal Effect Level (DN(M)EL)

This section provides information on the derived no- or minimal effect level (DN(M)EL), the level of exposure above which a human should not be exposed to a substance.

When more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

When more than one result is available per endpoint the ‘worst case’ or most conservative of all the data values provided are displayed, applying a precautionary principal. The aim is to display the lowest values reported as causing the most adverse effects, and hence the broadest possible safety margins for the substance.

Registrant can provide information on the long and acute/short term exposure for both systemic and local effects of inhalation exposure of workers and/or general population by selecting one of the following hazard assessment conclusions:

Hazard unknown but no further hazard information necessary as no exposure expected

Prioritisation of display occurs based on the order above. If a threshold is derived, the type of hazard assessment conclusion is displayed and the registered threshold is reported in (nano/micro/milli)gram per cubic metre. If more than one DNEL/DMEL is available the most conservative (i.e. the lowest numerical data) is displayed.

Information on the most sensitive study can be provided by the registrants as:

M/C Summaries

2 summaries submitted

2 summaries processed

The derived no- or minimum effect level (DN(M)EL) is the level of exposure above which a human should not be exposed to a substance. Please note that when more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Data for WORKERS

INHALATION Exposure

Threshold

Most sensitive study

Systemic Effects

Long-term:

(DNEL) 75 mg/m³

neurotoxicity

Acute /short term:

-

-

Local Effects

Long-term:

-

-

Acute /short term:

-

-

DERMAL Exposure

Threshold

Most sensitive study

Systemic Effects

Long-term:

(DNEL) 11 mg/kg bw/day

neurotoxicity

Acute /short term:

-

-

Local Effects

Long-term:

-

-

Acute /short term:

-

-

EYE Exposure

-

Data for the GENERAL POPULATION

INHALATION Exposure

Threshold

Most sensitive study

Systemic Effects

Long-term:

(DNEL) 16 mg/m³

neurotoxicity

Acute /short term:

-

-

Local Effects

Long-term:

-

-

Acute /short term:

-

-

DERMAL Exposure

Threshold

Most sensitive study

Systemic Effects

Long-term:

(DNEL) 5.3 mg/kg bw/day

neurotoxicity

Acute /short term:

-

-

Local Effects

Long-term:

-

-

Acute /short term:

-

-

ORAL Exposure

Threshold

Most sensitive study

Systemic Effects

Long-term:

(DNEL) 4 mg/kg bw/day

neurotoxicity

Acute /short term:

-

-

EYE Exposure

-

Toxicokinetics, metabolism, and distribution

Toxicokinetics, metabolism, and distribution

This section displays the values (see below) related to toxicokinetics, metabolism, and distribution from all registered dossiers for the substance.

Study results

For this endpoint registrants do not provide study result data.

Summary

Displayed is the MOST CONSERVATIVE of the value(s) provided, ranking in the order as below.

Registrants can register their substance’s oral/dermal/inhalation absorption rate values in percentages. If multiple values are available, the most conservative value (the highest percentage) is displayed.

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications.

Study results

Study data: basic toxicokinetics

2 studies submitted

0 studies processed

Study data not processed for brief profile

Type of Study provided

Study data: basic toxicokinetics

Studies with data

Key study

2

Supporting study

Weight of evidence

Other

Data waiving

no waivers

Study data: dermal absorption

0 studies submitted

0 studies processed

Study data not processed for brief profile

Study data: dermal absorption

Studies with data

Key study

Supporting study

Weight of evidence

Other

Data waiving

no waivers

Summaries

2 summaries submitted

0 summaries processed

No automatically processable data submitted

Acute toxicity

Acute toxicity

This section displays the values related to acute toxicity from all registered dossiers for the substance.

Study results - oral

Displayed are the RANGES of min – max of the PRIORITISED value(s) within the five highest priority groupings of provided data. Data is generally displayed in milligram per kilo bodyweight. The availability of additional data beyond the five results displayed is indicated by (…).

Results

Processable data for study results is prioritised by test species (see list below) and subsequently further prioritised by the dose descriptor.

Note: Registrants can also select ‘other’ as the test species, dose descriptor type and/or the unit of measure. If so, the data provided is not processed for the Brief Profile.

Applicant’s summary and conclusion – Interpretation of results (oral). Registrants can choose from the following (picklist) conclusions:

Category 1 based on GHS criteria

Category 2 based on GHS criteria

Category 3 based on GHS criteria

Category 4 based on GHS criteria

Category 5 based on GHS criteria

Study cannot be used for classification

GHS criteria not met

Extremely toxic

Very toxic

Highly toxic

Toxic

Moderately toxic

Slightly toxic

Toxicity category I

Toxicity category II

Toxicity category III

Toxicity category IV

Toxicity category V

Practically nontoxic

Harmful

Relatively harmless

Not classified

Other

Displayed is the MOST CONSERVATIVE of the value(s) provided, ranking in the order as above.

Note: Registrants can also select ‘other’ as the picklist conclusion. If so, the data provided is not processed for the Brief Profile.

Study results - dermal

Results

See information under ‘Study results oral’.

Applicant’s summary and conclusion – Interpretation of results(dermal). See information under ‘Applicant’s summary and conclusion – interpretation of results (oral)’.

Study results - Inhalation

Displayed are the RANGES of min – max of the PRIORITISED value(s) within the five highest priority groupings of provided data. Data is generally displayed in milligram per kilo bodyweight. The availability of additional data beyond the five results displayed is indicated by (…).

Results

Processable data for study results is prioritised by test species (see list below) and subsequently further prioritised by the dose descriptor. Within each of these categories, data is prioritised further by duration (in hours), with longer prioritised over shorter.

Study results - other routes

Displayed are the RANGES of min – max of the PRIORITISED value(s) within the five highest priority groupings of provided data. Data is generally displayed in milligram per kilo bodyweight. The availability of additional data beyond the five results displayed is indicated by (…) icon.

Results

Processable data for study results is prioritised by test species (see list below) and subsequently further prioritised by the dose descriptor.

Note: Registrants can also select ‘other’ as the test species, dose descriptor type and/or the unit of measure. If so, the data provided is not processed for the Brief Profile.

Summary

Displayed in all cases is the MOST CONSERVATIVE of the value(s) provided, ranking in the order as above, i.e. the minimum numerical value associated with the highest priority picklist item.

Oral route provides substance information on the substance’s acute toxicity via the oral route. Registrants can choose from the following picklist endpoint conclusions:

Adverse effect observed

No adverse effect observed

No study available

If an adverse effect is observed, data can be provided as LD 50 or discriminating dose, displayed here in milligrams per kilogram bodyweight.

Dermalroute provides substance information on the substance’s acute toxicity via the dermal route. Registrants can choose from the following picklist endpoint conclusions:

Adverse effect observed

No adverse effect observed

No study available

If an adverse effect is observed, data can be provided as LD 50 or discriminating dose, displayed here in milligrams per kilogram bodyweight.

Inhalationroute provides substance information on the substance’s acute toxicity via the inhalation route. Registrants can choose from the following picklist endpoint conclusions:

Adverse effect observed

No adverse effect observed

No study available

If an adverse effect is observed, data can be provided as LD 50 or discriminating concentration, displayed here in milligram per cubic metre.

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications.

Study results

oral

2 studies submitted

2 studies processed

P/RResults

LD50 24 - 49 mL/kg bw (rat) [6]

M/CInterpretations of results

Not classified [2]

Type of Study provided

oral

Studies with data

Key study

2

Supporting study

Weight of evidence

Other

Data waiving

no waivers

inhalation

6 studies submitted

4 studies processed

P/RResults

LC50 (24 h) 5 000 ppm (rat) [2]

LC50 (4 h) 73 860 ppm (rat) [2]

M/CInterpretations of results

Study cannot be used for classification [2]

inhalation

Studies with data

Key study

2

2

Supporting study

2

Weight of evidence

Other

Data waiving

no waivers

dermal

4 studies submitted

2 studies processed

P/RResults

LD50 5 mL/kg bw (rabbit) [2]

M/CInterpretations of results

Not classified [2]

dermal

Studies with data

Key study

2

Supporting study

2

Weight of evidence

Other

Data waiving

no waivers

other routes

0 studies submitted

0 studies processed

No data available

other routes

Studies with data

Key study

Supporting study

Weight of evidence

Other

Data waiving

no waivers

Summaries

2 summaries submitted

0 summaries processed

No automatically processable data submitted

Irritation / corrosion

Irritation / corrosion

This section displays the values related to irritation and corrosion from all registered dossiers for the substance.

Study results

For this endpoint registrants do not provide study results that are processable for the Brief Profile.

Summary

Displayed in all cases is the MOST CONSERVATIVE of the value(s) provided, ranking in the order as below.

Skin irritation/corrosion provides substance information on the substance’s irritation/corrosion effect on the skin. Registrants can choose from the following picklist endpoint conclusions/effect levels:

Endpoint conclusion – picklist

Adverse effect observed (irritating)

Adverse effect observed (corrosive)

No adverse effect observed (not irritating)

No study available

Eye irritation provides substance information on the substance’s irritation effect on the eye. Registrants can choose from the following picklist endpoint conclusions/effect levels:

Adverse effect observed (irreversible damage)

Adverse effect observed (irritating)

No adverse effect observed (not irritating)

No study available

Respiratory irritation provides substance information on the substance’s irritation effect on the respiratory system. Registrants can choose from the following picklist endpoint conclusions/effect levels:

<

Adverse effect observed (irritating)

No adverse effect observed (not irritating)

No study available

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications.

Study results

Study data: skin

6 studies submitted

0 studies processed

Study data not processed for brief profile

Type of Study provided

Study data: skin

Studies with data

Key study

2

Supporting study

2

Weight of evidence

Other

2

Data waiving

no waivers

Study data: eye

6 studies submitted

0 studies processed

Study data not processed for brief profile

Study data: eye

Studies with data

Key study

2

Supporting study

4

Weight of evidence

Other

Data waiving

no waivers

M/C Summaries

2 summaries submitted

2 summaries processed

Skin

No adverse effect observed (not irritating)

Eye

No adverse effect observed (not irritating)

Sensitisation

Sensitisation

This section displays the values related to sensitisation from all registered dossiers for the substance.

Study results

For this endpoint registrants do not provide study results that are processable for the Brief Profile.

Summary

Displayed in all cases is the MOST CONSERVATIVE of the value(s) provided, ranking in the order as below.

Skin sensitisation provides substance information on the substance’s sensitisation effect on the skin. Registrants can choose from the following picklist endpoint conclusions:

Adverse effect observed

No adverse effect observed (not irritating)

No study available

Respiratory sensitisation provides substance information on the substance’s sensitisation effect on the respiratory system. Registrants can choose the same picklist endpoint conclusions as mentioned under ‘Skin sensitisation’.

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications.

Study results

Study data: skin

4 studies submitted

0 studies processed

Study data not processed for brief profile

Type of Study provided

Study data: skin

Studies with data

Key study

2

Supporting study

2

Weight of evidence

Other

Data waiving

no waivers

Study data: respiratory

0 studies submitted

0 studies processed

Study data not processed for brief profile

Study data: respiratory

Studies with data

Key study

Supporting study

Weight of evidence

Other

Data waiving

no waivers

M/C Summaries

2 summaries submitted

2 summaries processed

Skin sensitisation

No adverse effect observed (not sensitising)

Repeated dose toxicity

Repeated dose toxicity

This section displays the values related to repeated dose toxicity from all registered dossiers for the substance.

Study results oral

Processable data for study results is prioritised by dose descriptor type (see list below) and subsequently further prioritised by the test species. Thirdly the display of data is prioritised by units.

Displayed are the RANGES of min – max of the PRIORITISED value(s) within the five highest priority groupings of provided data. Data is generally displayed in milligrams per kilogram bodyweight per day.

The availability of additional data beyond the five results displayed is indicated by (…).

Prioritization by dose descriptor type:

NOAEL

LOAEL

NOEL

LOEL

BMD05

BMDL05

BMDL10

BMC05

BMCL05

BMCL10

no NOAEL identified

Note: Registrants can also select ‘BMD’, ‘BMC’, ‘dose level’ and ‘conc. level’ as the dose descriptor. If so, the data provided is not processed for the Brief Profile.

Note: Registrants can also select ‘other’ as the test species, dose descriptor type and/or the unit of measure. If so, the data provided is not processed for the Brief Profile.

Study results inhalation

Processable data for study results is prioritised by dose descriptor type (see list below) and subsequently further prioritised by the test species. Thirdly the display of data is prioritised by units.

Displayed are the RANGES of min – max of the PRIORITISED value(s) within the five highest priority groupings of provided data. Data is generally displayed in milligram per litre air.

The availability of additional data beyond the five results displayed is indicated by (…).

Prioritization by dose descriptor type:

NOAEL

LOAEL

NOEL

LOEL

NOAEC

NOEC

LOAEC

LOEC

BMD05

BMDL05

BMDL10

BMC05

BMCL05

BMCL10

no NOAEL identified

no NOAEC identified

Note: Registrants can also select ‘BMD’, ‘BMC’, ‘dose level’ and ‘conc. level’ as the dose descriptor. If so, the data provided is not processed for the Brief Profile.Prioritization by test species:

Study results dermal

mg/cm² per day (combining mg/cm² per day, mg/cm² per day (nominal), mg/cm² per day (analytical))

Note: Registrants can also select ‘other’ as the test species, dose descriptor type and/or the unit of measure. If so, the data provided is not processed for the Brief Profile.

Summary oral – systemic effects

Processable data for the summary is prioritised by test species (see list below) and subsequently further prioritised by the dose descriptor. Displayed is the most conservative of the prioritised value(s). If more than one result with the same value, data is further prioritised by test type and endpoint conclusion.

Data is generally displayed in milligrams per kilogram bodyweight per day.

No study available / no study available (further information necessary)

Summary dermal - systemic effects

See ‘Summary oral systemic effects’

Summary dermal - local effects

See ‘Summary oral systemic effects’, except:

Unit of measure: mg/cm2

Summary inhalation - systemic effects

See ‘Summary oral Route’, except:

Unit of measure: mg/m3

Prioritisation by dose descriptor type:

NOAEC

LOAEC

BMCL05

BMC05

BMCL10

T25

Summary inhalation - local effects

‘See Summary inhalation systemic effects’

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications.

Study results

Study data: oral

2 studies submitted

0 studies processed

No automatically processable data submitted

Type of Study provided

Study data: oral

Studies with data

Key study

2

Supporting study

Weight of evidence

Other

Data waiving

no waivers

Study data: inhalation

12 studies submitted

4 studies processed

P/RResults

NOAEC (mouse): 500 ppm [2]

LOAEC (rat): 3 000 ppm [2]

LOAEC (mouse): 500 - 1 000 ppm [4]

Study data: inhalation

Studies with data

Key study

4

Supporting study

8

Weight of evidence

Other

Data waiving

no waivers

Study data: dermal

2 studies submitted

0 studies processed

No automatically processable data submitted

Study data: dermal

Studies with data

Key study

Supporting study

Weight of evidence

Other

Data waiving

Not feasible

Sci. unjustified

Exposure cons.

Other

2

Summaries

2 summaries submitted

0 summaries processed

No automatically processable data submitted

Genetic toxicity

Genetic toxicity

This section displays the values related to genetic toxicity from all registered dossiers for the substance.

Study results

For this endpoint registrants do not provide study results that are processable for the Brief Profile.

Summary

Processable data for study results is prioritised by endpoint conclusion: the most conservative value is displayed.

Prioritisation by endpoint conclusion:

Adverse effect observed

No adverse effect observed

No study available / no study available (further information necessary)

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications.

Study results

Study data: in vitro

12 studies submitted

0 studies processed

Study data not processed for brief profile

Type of Study provided

Study data: in vitro

Studies with data

Key study

6

Supporting study

6

Weight of evidence

Other

Data waiving

no waivers

Study data: in vivo

4 studies submitted

0 studies processed

Study data not processed for brief profile

Study data: in vivo

Studies with data

Key study

2

Supporting study

2

Weight of evidence

Other

Data waiving

no waivers

Summaries

2 summaries submitted

0 summaries processed

No automatically processable data submitted

Carcinogenicity

Carcinogenicity

This section displays the values related to carcinogenicity from all registered dossiers for the substance.

Study results

Study results are not processed for carcinogenicity in the context of Brief Profiles due to the use of complex field(s) to report the information, which cannot be easily summarised by an automatic algorithm.

Summary oral route

Processable data for summary is prioritised by test species (see list below) and subsequently further prioritised by the dose descriptor. Displayed is the most conservative of the prioritised value(s). If there is more than one result with the same value, data is further prioritised by test type and endpoint conclusion.

Data is generally displayed in milligrams per kilogram bodyweight per day.

Note: Registrants can also select ‘other’ as the test species. If so, the data provided is not processed for the Brief Profile.

Prioritisation by descriptor type:

NOAEL

LOAEL

T25

BMDL05

BMD05

BMDL10

Prioritisation by test type:

Chronic

Subchronic

Subacute

Prioritisation by endpoint conclusion:

Adverse effect observed

No adverse effect observed

No study available / no study available (further information necessary)

Summary dermal route

See ‘Summary oral Route’

Summary inhalation route

See ‘Summary oral Route’, except:

Measurement units: mg/m3

Prioritisation by dose descriptor type:

NOAEC

LOAEC

BMCL05

BMC05

BMCL10

T25

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications.

Study results

4 studies submitted

0 studies processed

Study data not processed for brief profile

Type of Study provided

Studies with data

Key study

4

Supporting study

Weight of evidence

Other

Data waiving

no waivers

Summaries

2 summaries submitted

0 summaries processed

No automatically processable data submitted

Toxicity to reproduction

Toxicity to reproduction

This section displays the values related to reproductive toxicity from all registered dossiers for the substance.

Study results

Study results are not processed for carcinogenicity in the context of Brief Profiles due to the use of complex field(s) to report the information, which cannot be easily summarised by an automatic algorithm.

Summary effect on fertility oral route

Processable data for study results is prioritised by test species (see list below) and subsequently further prioritised by the dose descriptor. Displayed is the most conservative of the prioritised value(s). If there is more than one result with the same value, data is further prioritised by test type and endpoint conclusion.

Data is generally displayed in milligrams per kilogram bodyweight per day.Prioritization by test species:

Note: Registrants can also select ‘other’ as the test species. If so, the data provided is not processed for the Brief Profile.

Prioritisation by descriptor type:

NOAEL

LOAEL

T25

BMDL05

BMD05

BMDL10

Prioritisation by test type:

Chronic

Subchronic

Subacute

Prioritisation by endpoint conclusion:

Adverse effect observed

No adverse effect observed

No study available / no study available (further information necessary)

Summary effect on fertility dermal route

See ‘Summary effect on fertility oral route’

Summary effect on fertility inhalation route

See ‘Summary effect on fertility oral route’, except:

Dose descriptor prioritization:

NOAEC

LOAEC

BMCL01

BMC05

BMCL10

Measurement units: mg/m3

Summary developmental toxicity oral route

See ‘Summary effect on fertility oral route’

Summary developmental toxicity dermal route

See ‘Summary effect on fertility oral route’

Summary developmental toxicity inhalation route

See ‘Summary effect on fertility oral route’, except:

Dose descriptor prioritization:

NOAEC

LOAEC

BMCL01

BMC05

BMCL10

Measurement units: mg/m3

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications.

Study results

Study data: reproduction

3 studies submitted

0 studies processed

Study data not processed for brief profile

Type of Study provided

Study data: reproduction

Studies with data

Key study

2

1

Supporting study

Weight of evidence

Other

Data waiving

no waivers

Study data: developmental

8 studies submitted

0 studies processed

Study data not processed for brief profile

Study data: developmental

Studies with data

Key study

2

4

Supporting study

2

Weight of evidence

Other

Data waiving

no waivers

Study data: other studies

0 studies submitted

0 studies processed

Study data not processed for brief profile

Study data: other studies

Studies with data

Key study

Supporting study

Weight of evidence

Other

Data waiving

no waivers

Summaries

2 summaries submitted

0 summaries processed

No automatically processable data submitted

Neurotoxicity

Neurotoxicity

This section displays the values related to neurotoxicity from all registered dossiers for the substance.

Study results

For this endpoint registrants do not provide study results that are processable for the Brief Profile.

Summary oral route

Processable data for study results is prioritised by test species (see list below) and subsequently further prioritised by the dose descriptor. Displayed is the most conservative of the prioritised value(s). If there is more than one result with the same value, data is further prioritised by test type and endpoint conclusion.

Data is generally displayed in milligrams per kilogram bodyweight per day.

No study available / no study available (further information necessary)

Summary dermal route

See ‘Summary oral route’

Summary inhalation route

See ‘Summary oral route’, except:

Dose descriptor prioritization:

NOAEC

LOAEC

BMCL01

BMC05

BMCL10

Measurement units: mg/m3

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications.

Study results

2 studies submitted

0 studies processed

Study data not processed for brief profile

Type of Study provided

Studies with data

Key study

2

Supporting study

Weight of evidence

Other

Data waiving

no waivers

Summaries

2 summaries submitted

0 summaries processed

No automatically processable data submitted

Immunotoxicity

Immunotoxicity

This section displays the values related to immunotoxicity from all registered dossiers for the substance.

Study results

For this endpoint registrants do not provide study results that are processable for the Brief Profile.

Summary oral route

Processable data for study results is prioritised by test species (see list below) and subsequently further prioritised by the dose descriptor. Displayed is the most conservative of the prioritised value(s). If there is more than one result with the same value, data is further prioritised by test type and endpoint conclusion.

Data generally displayed in milligrams per kilogram bodyweight per day.

No study available / no study available (further information necessary)

Note: Registrants can also select ‘other’ as the test species, dose descriptor type and/or the unit of measure. If so, the data provided is not processed for the Brief Profile.

Summary dermal route

See ‘Summary oral route’

Summary inhalation route

See ‘Summary oral route’, except:

Dose descriptor prioritization:

NOAEC

LOAEC

BMCL01

BMC05

BMCL10

Measurement units: mg/m3

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications.

Data not provided by the registrant

Endocrine disrupter mammalian screening - in vivo

Endocrine disrupter mammalian screening - in vivo

This section displays the values related to endocrine disrupter mammalian screening from all registered dossiers for the substance.

Study results

If more than one value is available, results are displayed as concatenated distinct values, ordered by most to least commonly provided, with the % of provided values appended. The % is based on count of values provided.

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications.

The brief profile is based on non-confidential data contained in ECHA’s databases at the time of generation. Please be aware that as additional data is submitted to ECHA, the brief profile will also be updated to reflect the new situation. All data remain the property of its respective owners.Note that the brief profile is an automatically generated summary and that not all available data may be displayed. The content is subject to change without prior notice. The information has not been reviewed or verified by ECHA or any other authority. The Agency thus cannot guarantee the correctness of the information displayed. The identification of applicable legislative frameworks is done automatically and without manual verification. Therefore this does not constitute official and legally binding information. To confirm if a substance is covered by a specific legislative framework the official publication should be consulted.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner. The Agency does not take any responsibility whatsoever for any copyright or other infringements that may be caused by using the information. This brief profile is covered by the ECHA Legal Notice.