28 Sep 2012PDMR Share Dealing

September 28, 2012 – Shire plc (LSE: SHP, NASDAQ: SHPG), announces that Ms Tatjana May was granted today, under the Shire Sharesave Scheme, an option over 579 ordinary shares at an exercise price of £15.54 per share.

This notification relates to disclosures made in accordance with 3.1.4(R)(1)(a) of the Disclosure and Transparency Rules.