Citations in PubMed

PDB ID Mentions in PubMed Central
Article count: 7

Citations in PubMed

This linkout lists citations, indexed by PubMed, to the Primary Citation for this PDB ID.

PDB ID Mentions in PubMed Central

Data mentions are occurrences of PDB IDs in the full text articles from the
PubMedCentral Open Access Subset
of currently about 1 million articles. For each article, the sentences containing the PDB ID are listed.
Article titles can be filtered by keywords and sorted by year.

Discussion The structural biology of the N-terminal and C-terminal regions of fH that encompas the known binding sites for its principal protein and carbohydrate ligands, has been studied extensively;... the medium-resolution or high-resolution structures of all eight N-terminal CCPs have been experimentally determined {in fragments: fH1–2 [Protein Data Bank (PDB) ID 2RLP ], fH2–3 (PDB ID 2RLQ ), fH1–4 (PDB ID 2WII ), and fH5 and fH6–8 (PDB ID 2UWN )} by NMR or crystallography, as have structures of four of the C-terminal six modules [fH15–16 (PDB ID 1HFH ) and fH19–20 (PDB IDs 2BZM and 2G7I )].

Publication Year: 2010

Structural basis for engagement by complement factor H of C3b on a self surface.

Color code: C3b (2WII, [44] ) is shown in blue and its C3d part (TED domain) is darker blue with the thioester site in orange (1C3d, [7] ); a microbial protein is shown in yellow; FH19-20 is shown in ... rey (2g7i, [8] ).

The first two CR domains of P-selectin were modeled using the homology model module in Molecular Operating Environment (MOE) based on six templates (PDB codes: 2G7I, 1RID, 1OK3, 1GKN, 2RLQ, 1PPQ), and... the selection of templates was based on a combination of MOE (E-value ≤ 10 –12 ) and Blast (Blast-score ≥ 25) sequence homology searches [ 22 ].

Based on sequence homology searches by both MOE and Blast, six templates (PDB codes: 2G7I, 1RID, 1OK3, 1GKN, 2RLQ, 1PPQ) were chosen for the homology modeling of P-selectin CR domains.

However, only the modeled structures based on the 2RLQ and 1OK3 templates showed low ratios of unreasonable structures ( S1 Table , gray boxes ) according to stereochemistry rationality, and the disulfide bond distributions in templates 2G7I and 2RLQ ( B ) were similar with that found in the P-selectin CR domain ( A ) ( S2 Table ).

C , locations of the residues involved in binding of autoantibodies to CFH 19–20 as indicated in dark gray and annotated on a previously published structure of CFH 19–20 (Protein Data ... ank code 2G7I ) ( 7 ).

Potentials on the solvent-accessible surfaces were calculated and displayed at the ±2 kT /e level on both structures after modeling all of the missing side chains of the previously published structure of CFH 19–20 (Protein Data Bank code 2G7I ) ( 7 ).