Three Structure-Selective Endonucleases Are Essential in the Absence of BLM Helicase in Drosophila

Figure 1

Apoptosis in larval imaginal discs.

Apoptosis levels are expressed as the average number of cells per imaginal wing disc that stain with antibody to cleaved caspase-3. n = number of discs scored. mus81 and Gen mutant larvae had apoptosis levels indistinguishable from the wild-type control (y w), but mus81 Gen double mutants had significantly increased apoptosis compared to either wild-type or either of the single mutants. *** p<0.0001 (Fisher's exact test).