GREMLIN Results:
Residue pairs sorted by strength in covariance:Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

i

j

Raw Score

Scaled Score

152_R

175_H

1.1578

4.062

92_D

117_R

1.08763

3.815

161_A

165_R

0.99991

3.508

43_R

46_K

0.85691

3.006

161_A

176_V

0.7564

2.653

162_E

166_K

0.74615

2.618

158_E

162_E

0.72382

2.539

122_V

154_L

0.69746

2.447

99_L

114_A

0.62311

2.186

155_A

174_V

0.61787

2.168

98_L

122_V

0.6165

2.163

43_R

47_Q

0.59369

2.083

88_R

117_R

0.59367

2.083

120_P

151_D

0.57099

2.003

25_W

91_L

0.55523

1.948

90_F

94_W

0.55017

1.930

101_W

121_V

0.54281

1.904

100_I

122_V

0.53188

1.866

54_L

94_W

0.52919

1.856

162_E

165_R

0.52745

1.850

25_W

54_L

0.49272

1.728

24_I

98_L

0.48851

1.714

158_E

161_A

0.48541

1.703

155_A

161_A

0.48451

1.700

123_L

150_F

0.4681

1.642

157_S

160_D

0.45989

1.613

26_I

41_I

0.44408

1.558

141_F

144_R

0.43202

1.516

89_R

93_H

0.41592

1.459

115_K

151_D

0.41521

1.457

48_R

51_L

0.41295

1.449

109_N

147_L

0.40972

1.437

88_R

92_D

0.40068

1.406

161_A

174_V

0.39599

1.389

148_S

153_I

0.38722

1.358

115_K

149_R

0.38345

1.345

91_L

114_A

0.37126

1.302

158_E

176_V

0.36924

1.295

40_L

100_I

0.36777

1.290

42_K

46_K

0.366

1.284

81_L

85_W

0.36392

1.277

150_F

153_I

0.36083

1.266

122_V

152_R

0.36081

1.266

38_R

42_K

0.35946

1.261

26_I

100_I

0.35296

1.238

82_D

86_A

0.35206

1.235

98_L

120_P

0.34965

1.227

41_I

45_R

0.34929

1.225

88_R

113_E

0.34612

1.214

45_R

73_R

0.34493

1.210

37_A

104_T

0.34353

1.205

154_L

177_T

0.34208

1.200

67_R

71_P

0.33121

1.162

83_F

86_A

0.32619

1.144

85_W

89_R

0.32354

1.135

25_W

96_P

0.32274

1.132

25_W

90_F

0.31817

1.116

153_I

164_F

0.31815

1.116

99_L

121_V

0.31492

1.105

135_R

142_L

0.31312

1.098

159_A

162_E

0.30461

1.069

39_P

42_K

0.30438

1.068

155_A

164_F

0.30138

1.057

64_E

68_K

0.30073

1.055

85_W

88_R

0.29786

1.045

42_K

45_R

0.29648

1.040

125_N

179_N

0.29555

1.037

44_L

51_L

0.28626

1.004

40_L

180_L

0.2854

1.001

25_W

94_W

0.28449

0.998

135_R

151_D

0.28414

0.997

26_I

44_L

0.2841

0.997

86_A

89_R

0.28376

0.995

153_I

169_A

0.2819

0.989

27_H

87_V

0.28147

0.987

47_Q

50_D

0.27732

0.973

121_V

150_F

0.27545

0.966

158_E

165_R

0.27523

0.966

41_I

53_I

0.2736

0.960

163_R

166_K

0.27151

0.952

100_I

124_V

0.26593

0.933

145_P

148_S

0.26502

0.930

82_D

85_W

0.26362

0.925

134_R

179_N

0.26178

0.918

85_W

92_D

0.26097

0.915

110_L

146_L

0.26073

0.915

36_A

156_Q

0.2595

0.910

65_M

68_K

0.25809

0.905

98_L

152_R

0.25605

0.898

138_R

142_L

0.25264

0.886

52_R

97_D

0.25116

0.881

126_A

155_A

0.25089

0.880

132_S

164_F

0.24994

0.877

89_R

92_D

0.24922

0.874

91_L

117_R

0.24908

0.874

101_W

123_L

0.24404

0.856

45_R

52_R

0.24372

0.855

113_E

117_R

0.24028

0.843

165_R

170_P

0.23756

0.833

36_A

125_N

0.23662

0.830

57_T

76_V

0.23639

0.829

60_P

64_E

0.23438

0.822

155_A

176_V

0.23378

0.820

83_F

87_V

0.23371

0.820

37_A

100_I

0.22853

0.802

114_A

121_V

0.22693

0.796

36_A

104_T

0.22638

0.794

125_N

128_L

0.22605

0.793

39_P

43_R

0.22543

0.791

170_P

174_V

0.22507

0.790

91_L

99_L

0.22462

0.788

165_R

174_V

0.22445

0.787

99_L

119_I

0.22378

0.785

142_L

146_L

0.22336

0.784

88_R

116_R

0.22256

0.781

148_S

169_A

0.21849

0.766

26_I

40_L

0.21697

0.761

33_E

107_W

0.21697

0.761

55_L

66_A

0.2162

0.758

57_T

60_P

0.21436

0.752

121_V

149_R

0.21394

0.751

156_Q

160_D

0.2136

0.749

140_P

167_L

0.21342

0.749

40_L

124_V

0.21278

0.746

104_T

109_N

0.21238

0.745

60_P

65_M

0.21141

0.742

155_A

179_N

0.21075

0.739

156_Q

179_N

0.21055

0.739

147_L

153_I

0.21033

0.738

140_P

143_F

0.20842

0.731

163_R

167_L

0.20808

0.730

98_L

175_H

0.20639

0.724

143_F

147_L

0.20598

0.723

145_P

149_R

0.20515

0.720

95_R

117_R

0.20497

0.719

155_A

160_D

0.2042

0.716

54_L

90_F

0.20377

0.715

111_L

150_F

0.20369

0.715

33_E

41_I

0.2032

0.713

30_S

33_E

0.20194

0.708

65_M

69_L

0.20158

0.707

52_R

94_W

0.20064

0.704

169_A

181_K

0.20051

0.703

51_L

97_D

0.2005

0.703

79_L

82_D

0.20032

0.703

165_R

168_G

0.20008

0.702

35_N

38_R

0.19952

0.700

24_I

44_L

0.19951

0.700

80_P

140_P

0.19924

0.699

32_G

36_A

0.19833

0.696

144_R

147_L

0.19832

0.696

63_R

76_V

0.19782

0.694

25_W

99_L

0.19752

0.693

33_E

105_E

0.19734

0.692

60_P

78_Y

0.1968

0.690

74_V

77_Q

0.19648

0.689

115_K

118_G

0.19503

0.684

144_R

149_R

0.19497

0.684

143_F

146_L

0.19491

0.684

28_A

37_A

0.19356

0.679

79_L

114_A

0.19338

0.678

112_R

116_R

0.19225

0.674

64_E

67_R

0.18995

0.666

123_L

126_A

0.18938

0.664

100_I

180_L

0.1876

0.658

106_L

123_L

0.18757

0.658

37_A

41_I

0.18719

0.657

140_P

144_R

0.18692

0.656

56_T

59_T

0.18686

0.656

87_V

91_L

0.18663

0.655

135_R

138_R

0.18584

0.652

33_E

126_A

0.18309

0.642

84_P

88_R

0.18269

0.641

160_D

164_F

0.18265

0.641

24_I

122_V

0.18264

0.641

28_A

34_V

0.18238

0.640

104_T

180_L

0.18231

0.640

169_A

174_V

0.18226

0.639

154_L

175_H

0.18197

0.638

111_L

121_V

0.18138

0.636

33_E

179_N

0.18085

0.634

48_R

52_R

0.18038

0.633

141_F

148_S

0.17998

0.631

135_R

143_F

0.17973

0.630

90_F

93_H

0.17895

0.628

160_D

163_R

0.17884

0.627

158_E

170_P

0.17805

0.625

55_L

63_R

0.17799

0.624

153_I

174_V

0.17735

0.622

126_A

160_D

0.17641

0.619

31_V

105_E

0.17623

0.618

36_A

126_A

0.17609

0.618

47_Q

51_L

0.17606

0.618

45_R

72_D

0.176

0.617

125_N

160_D

0.17548

0.616

33_E

178_G

0.17533

0.615

58_T

65_M

0.17483

0.613

26_I

51_L

0.17474

0.613

49_P

70_L

0.17412

0.611

36_A

177_T

0.17358

0.609

30_S

34_V

0.17346

0.609

63_R

67_R

0.17344

0.608

33_E

104_T

0.17251

0.605

105_E

127_R

0.17172

0.602

32_G

128_L

0.17139

0.601

142_L

145_P

0.17127

0.601

96_P

119_I

0.171

0.600

177_T

180_L

0.1702

0.597

61_T

65_M

0.16975

0.595

33_E

36_A

0.16899

0.593

80_P

108_P

0.16891

0.593

63_R

66_A

0.16839

0.591

69_L

133_F

0.1682

0.590

97_D

100_I

0.16818

0.590

164_F

174_V

0.16758

0.588

125_N

156_Q

0.16678

0.585

25_W

55_L

0.16662

0.585

91_L

119_I

0.1662

0.583

36_A

123_L

0.16603

0.582

36_A

39_P

0.16556

0.581

86_A

93_H

0.1652

0.580

133_F

166_K

0.16512

0.579

44_L

48_R

0.16507

0.579

123_L

164_F

0.16424

0.576

Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.

HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits: Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)