Pose is set in the world of 1987 and "looks at the juxtaposition of several segments of life and society in New York: the rise of the luxury universe, the downtown social and literary scene and the ball culture world."

With the United States gripped in the panic of the Cold War, President Dwight D. Eisenhower deems homosexuals to be "security risks" and orders the immediate firing of any government employee discovered to be gay or lesbian. It triggers a vicious witch hunt that lasts for forty years and ruins thousands of lives, while thrusting an unlikely hero into the forefront of what would become the modern LGBT rights movement.

Zurich, 1956. The young teacher Ernst Ostertag falls head over heels in love with the transvestite star Robi Rapp and finds himself torn between his bourgeois existence and his commitment to homosexuality.

Jackie, an 80-year-old heterosexual drag queen, forms an unlikely friendship with Faith, a younger gender fluid queen after he’s been diagnosed with terminal cancer. As they discover more about each other, they realise that true happiness can only be found when we are true to ourselves.

Pete Logsdon is just a guy in Philadelphia who happens to have a history of getting involved with married men. His father and his soon-to-be step mom are on him to find someone who’s actually available and to settle down. Instead, he finds a man named Jack who is fifteen years into a perfect marriage with two beautiful children and an enviable wife.