GIANT consortium data files

From Giant Consortium

We are releasing the summary data from our 2010-2013 meta-analyses of Genome-wide Association (GWA) data, in order to enable other researchers to examine particular variants or loci for their evidence of association with anthropometric traits. The files include p-values and direction of effect at over 2 million directly genotyped or imputed single nucleotide polymorphisms (SNPs). To prevent the possibility of identification of individuals from these summary results, we are not releasing allele frequency data from our samples.

GIANT Consortium 2010 GWAS Metadata is Available Here for Download

2010 Data File Description:

Each file consists of the following information for each SNP and its association to the specified trait based on meta-analysis in the respective publication. SNPs where N < 50% of the maximum have been excluded.

Allele1: The first allele, by definition the trait-increasing allele (hg18 + strand)

Allele2: The second allele (hg18 + strand)

Freq.Allele1.HapMapCEU: The allele frequency of Allele1 in the HapMap CEU population

P: P value after meta-analysis using regression coefficients (beta and standard error), and after correction for inflation of test statistics using genomic control both at the individual study level and again after meta-analysis

GIANT consortium 2012-2013 GWAS Metadata is Available Here for Download

2012-2013 Data File Description:

Each file consists of the following information for each SNP and its association to the specified trait based on meta-analysis in the respective publication. Significant digits for the p values, betas and standard errors are limited to two digits to further limit the possibility of identifiability.

Allele1: The first allele (hg19 + strand). Where the regression coefficients (betas) are provided, the first allele is the effect allele. Where betas are not provided (typically the 2010 data), the first allele is the trait-increasing allele.

Allele2: The second allele (hg19 + strand)

Freq.Allele1.HapMapCEU: The allele frequency of Allele1 in the HapMap CEU population

b: beta

SE: standard error

p: p-value after meta-analysis using regression coefficients (beta and standard error), and after correction for inflation of test statistics using genomic control both at the individual study level and again after meta-analysis