Regulation of transepithelial sodium transport by corticosteroids occurs in two phases: early and delayed. The early phase involves the activation and translocation of pre-existing epithelial sodium channels (ENaC); whereas, the delayed phase...

Hypertensive disorders, as well as congestive heart disease. Despite extensive research on the regulatory events that occur between aldosterone induced transcription and the early activation of epithelial sodium channels (ENaC ) in cortical...

Early renal changes during diabetes include sodium (Na) retention and renal hypertrophy. Tumor Necrosis Factor (TNF) is elevated during diabetes and is implicated in the pathogenesis of diabetic nephropathy. We tested the hypothesis that TNF...

Nearly one billion individuals worldwide have elevated blood pressure (BP) and 90% of these cases are due to unknown causes. Aldosterone is the primary hormone regulating Na + reabsorption in the kidney and is therefore a major determinant of the...

It is well established that SGK1 plays a role in aldosterone mediated sodium transport. The intracellular localization of SGK1 has recently been demonstrated as mitochondrial. The studies described here evaluate the hypothesis that SGK1...

Gustatory pheromones regulate mating behaviors in Drosophila melanogaster and represent an important model for understanding how sensory stimuli can drive behavior. However, the genes and cells involved in pheromone detection have remained poorly...

IL-1β is a potent proinflammatory cytokine produced in response to Pseudomonas aeruginosa infection. While it is appreciated that IL-1β is a critical modulator of the host response to P. aeruginosa infection, the host and bacterial determinants...

After more than 150 years of studying the respiratory effects of hypercapnia, the intrinsic neuronal mechanism by which carbon dioxide (CO²) stimulates electrical excitability of respiratory neurons, and hence respiratory drive, is still...