Bridges will play university chancellor Barton Scully, Masters’ boss, while Martindale will guest star as Miss Horchow, his by-the-book secretary. (On "A Gifted Man," she plays right-hand woman to Patrick Wilson's brilliant physician. The show has fared poorly on Friday nights, and made TheWrap's recent list of 6 Shows We Think Are Doomed.)

"Masters of Sex" adapts Thomas Maier's book "Masters of Sex: The Life and Times of William Masters and Virginia Johnson, The Couple Who Taught America How To Love." Michelle Ashford (“The Pacific”), Judith Verno, and Sarah Timberman and Carl Beverly (“Justified”) are executive producers. Sheen and Tammy Rosen will serve as producers. The show is produced by Sony Pictures Television.

Bridges has received 14 Emmy nominations and won three times. He has received four Golden Globe nomination and won twice. His television credits include "Brothers & Sisters," "Stargate: SG-1," "My Name is Earl," "Desperate Housewives," "Into The West," "Without Warning: The James Brady Story," and Showtime's "Out of the Ashes. " Film credits include "The Fabulous Baker Boys and "Jerry Maguire."

Martindale's TV credits include Showtime's "Dexter," as well as "Lonesome Dove," "Medium," "Hung" and "The Riches." Her film credits include "Million Dollar Baby," "Dead Man Walking," "The Hours," and "Paris, je t'aime." She received a Tony Award nomination for her portrayal of Big Mama in the revival of Tennessee Williams’ "Cat on a Hot Tin Roof."