School of Medicine

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Current Research and Scholarly Interests
Our group’'s research focus is the acute treatment and prevention of cerebrovascular disorders. Our primary interest is the use of advanced imaging techniques to expand the treatment window for ischemic stroke. We are also conducting clinical studies of both neuroprotective and thrombolytic strategies for the treatment of acute stroke and investigating new antithrombotic strategies for stroke prevention.

Current Research and Scholarly Interests
Our research focuses on understanding how immune responses initiate and accelerate synaptic and neuronal injury in age-related neurodegeneration, including models of Alzheimer's disease and Parkinson's disease. We also focus on the role of immune responses in aggravating brain injury in models of stroke. Our goal is the identification of critical immune pathways that function in neurologic disorders and that can be targeted to elicit disease modifying effects.

Current Research and Scholarly Interests
My current research interests involve novel treatment paradigms for challenging pain problems such as orofacial pain, trigeminal neuralgia and low pressure headaches. I am also interested in migraine and trigeminal autonomic cephalgias. Finally I amI interested in the intersection between chronic pain and headache.

Current Research and Scholarly Interests
I am researching the neurobiology underlying cognitive problems in pediatric epilepsy. I am using transcranial magnetic stimulation paired with EMG and EEG to study cortical excitability and plasticity in children with benign epilepsy with centrotemporal spikes (BECTS or Rolandic Epilepsy). I am investigating whether changes in plasticity affect a child's ability to learn.

Current Research and Scholarly Interests
My research focus is human motor control and brain pathophysiology in movement disorders. Our overall goal is to understand the role of the basal ganglia electrical activity in the pathogenesis of movement disorders. We have developed novel computerized technology to measure fine, limb and postural movement. With these we are measuring local field potentials in basal ganglia nuclei in patients with Parkinson's disease and dystonian and correlating brain signalling with motor behavior.

Current Research and Scholarly Interests
We seek to understand the mechanisms responsible for the resistance of cancers to treatment and to develop strategies to overcome these resistances. We are using molecular and cellular techniques and mouse models to potentiate the activity of radiation on tumors by inhibiting the bone marrow rescue of the tumor vasculature following therapy.

Current Research and Scholarly Interests
One of Axel Brunger's major goals is to decipher the molecular mechanisms of synaptic neurotransmitter release by conducting imaging and single-molecule/particle reconstitution experiments, combined with near-atomic resolution structural studies of the synaptic vesicle fusion machinery.