EURL ECVAM supports the activities of the SEURAT-1 Safety
Assessment Working Group and contributes to the ultimate Proof-of-Concept of
the SEURAT-1 research initiative, i.e. to demonstrate that safety assessment of
chemicals for repeated dose toxicity can be made by an improved read across
from data rich to data poor substances not only based on structural relation
but by additional evidence from alternative methods.

SEURAT-1 is a 5 year Research Initiative started in 2011
aiming on the replacement of repeated dose systemic toxicity testing in vivo,
used for the assessment of human safety (Safety Evaluation Ultimately Replacing
Animal Testing). The overall goal is the development of in vitro and in silico
test systems based on mechanistic understanding of toxicological effects caused
through repeated exposure, which can ultimately support regulatory safety
assessment. Seurat-1 has a 50 million Euro funding jointly available from the
European Union’s Health Programme and the European Cosmetics Industry aiming on
making animal testing obsolete.