..To characterize the optical properties of lenses from mice deficient in the gene for lens intrinsic membrane protein-2 (Lim2), which encodes the second most abundant integral protein (Lim2) of lens fiber cell plasma membranes...

..These studies provide the first direct evidence that GJA8 plays a vital role in the maintenance of human lens transparency and identify the genetic defect believed to underlie the first inherited disease to be linked to a human autosome...

Milam A BrantleyDepartment of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Missouri 63110, USAOphthalmology 114:2168-73. 2007

..To investigate whether there is an association between complement factor H (CFH) or LOC387715 genotypes with response to treatment with intravitreal bevacizumab for exudative age-related macular degeneration (AMD)...

A ShielsDepartment of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO, USAClin Genet 84:120-7. 2013

..The set of genes currently known to be associated with cataract is far from complete, especially for age-related cataract, and there is much additional information to be discovered through further genetic studies. ..

..The results of this study suggest that MIP has essential roles in the establishment and maintenance of uniform fiber structure, and the organization of fibers, and as such is essential for lens function...