Special Instructions: Sample should be collected as a trough immediately prior to the administration of the next dose of valproic acid. Write the date and time of the last dose of valproic acid on the requisition.

Transport: Store serum at 2°C to 8°C after collection and ship the same day per packaging instructions provided with the Cleveland HeartLab shipping box.

Intended Use: The test is used to monitor therapeutic levels of valproic acid.

Clinical Significance: Valproic acid is used as an anticonvulsant to treat certain types of seizures, to prevent migraine headaches, and to prevent various psychiatric illnesses such as bipolar disorder and aggression. Drugs that compete for protein-binding sites with valproic acid can increase the concentration of valproic acid. Therapeutic drug monitoring is useful to optimize dose. Measurement of the free concentration is useful if toxicity is suspected.

Additional Information: Prescription and over-the-counter medications may raise, lower, or interfere with the levels of valproic acid.

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

CPT Disclaimer

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.