A, Distribution of IL-7+ and osteopontin+ cells in BM. B, Bglap (osteocalcin), Cxcl12, and Il7 expression in osteoblasts by qPCR. Gene expression is relative to Hprt. Data in A and B are representative of 3–5 independent experiments. C, Total number of hematopoietic cell subsets in BM of Il7fl/−; Col2.3-cre+ mice and control littermates. D, Total number of hematopoietic cell subsets in BM of Il7fl/−; Vav-cre+ mice and control littermates. Bars indicate average, circles depict individual mice. Data panels C and D are representative of at least 3 independent experiments with 4–6 mice per group. See also .