However, the method perfectly detected and differentiated variola from monkeypox virus (endemic in Africa), from cowpox virus (endemic in Europe but responsible for only limited cutaneous lesions in immunocompetent people), and also from vaccinia virus, thus helping to ascertain the diagnosis of complications of a smallpox vaccination in clinical practice (e.

Although monkeypox virus (MPXV) can infect a wide variety of animal species when experimentally introduced, it is currently unknown which species are directly involved in its natural transmission cycle and whether [greater than or equal to] 1 species are responsible for MPXV perpetuation in nature (3).

NASDAQ: SIGA) today announced that its lead smallpox drug, ST-246, has passed another milestone by demonstrating 100% protection against death in cynomolgus monkeys showing signs of infection with monkeypox virus as part of a primate trial conducted at the U.

It has already demonstrated significant antiviral activity in various animal trials, including the complete elimination of human smallpox virus or the related monkeypox virus in several primate studies.

Monkeypox virus occurs in western and central Africa, causes a disseminated infection in humans, can be transmitted among humans at a low rate, and is associated with a 1%-10% (depending on the virus strain) case-fatality rate.

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