Carboplatin Rx

Therapeutic Use:

Indications for Carboplatin:

Initial treatment of advanced ovarian cancer in combination with other chemotherapy. Secondary treatment of recurrent ovarian cancer after prior chemotherapy, including patients previously treated with cisplatin.

Adult:

See literature. Give by IV infusion over ≥15 minutes. Combination therapy with cyclophosphamide (previously untreated): 300mg/m2 on Day 1 every 4 weeks for 6 cycles. As a single agent for recurrent ovarian carcinoma: 360mg/m2 on Day 1 every 4 weeks. In either case the Calvert equation may be used (Total Dose [mg]=[target area under the curve (AUC)] X [glomerular filtration rate + 25]). Use Calvert equation for elderly patients. Adjust dose for renal insufficiency and blood counts (see literature).