Therapeutic actions

Azathioprine is an immunosuppressant, which inhibits DNA, RNA and protein synthesis and antagonises purine synthesis. It also inhibits mitosis and interferes with cellular metabolism of susceptible organisms. Azathioprine inj should be discontinued as soon as oral therapy can be introduced

Indications

Renal homotransplantation: Adjunct for prevention of rejection

Rheumatoid arthritis: Use only with adults meeting criteria for classic rheumatoid arthritis and not responding to conventional management