anti-Lysyl Oxidase (LOX) Antibodies

The protein encoded by LOX is an extracellular copper enzyme that initiates the crosslinking of collagens and elastin. Additionally we are shipping LOX Kits (34) and LOX Proteins (15) and many more products for this protein.

More Antibodies against LOX Interaction Partners

Zebrafish Lysyl Oxidase (LOX) interaction partners

Data reveal a role for lysyl oxidase in early morphogenesis, especially in muscle development and neurogenesis, and resume some aspects of physiopathology of copper metabolism.

Human Lysyl Oxidase (LOX) interaction partners

LOX gene expression was approximately 2.5-fold higher in fetal membranes from preterm prelabor rupture of membranes (pPROM (show SERPINH1 Antibodies)) compared to preterm and term birth.

The data suggest a fibromodulin (show FMOD Antibodies)-modulated collagen cross-linking mechanism where fibromodulin (show FMOD Antibodies) binds to a specific part of the collagen domain and also forms a complex with lysyl oxidase, targeting the enzyme toward specific cross-linking sites.

Individuals with LOX variants had fusiform enlargement of the aortic root and ascending thoracic aorta, leading to ascending aortic dissections.

two LOX variants, rs2956540 and rs10519694, may affect individual susceptibility to keratoconus

LOX expression at the mRNA and protein level, and enzymatic activity were remarkably upregulated in the hypoxic A549 cells, compared with normoxic A549 cells.

Aortic tissue from Marfan syndrome patients and display enhanced expression of the members of the LOX family, LOX and LOX-like 1.

Evidence for association was found for both of the tested loci.It was strongest for rs3735520:G>A near HGF (show HGF Antibodies) with A allele being a risk factor and rs2956540:G>C within LOX with C allele having a protective effect

Mouse (Murine) Lysyl Oxidase (LOX) interaction partners

LOX family members contribute significantly to the detrimental effects of cardiac remodelling, highlighting LOX inhibition as a potential therapeutic strategy for post-infarction recovery

Findings suggest that the lysyl oxidase (LOX)-mediated organization of collagen fibers in the extracellular matrix is an important regulator of osteoblastogenesis.

The data suggest a fibromodulin (show FMOD Antibodies)-modulated collagen cross-linking mechanism where fibromodulin (show FMOD Antibodies) binds to a specific part of the collagen domain and also forms a complex with lysyl oxidase, targeting the enzyme toward specific cross-linking sites.

Inhibition of tissue transglutaminase (show TGM2 Antibodies) resulted in a reduced rate of compaction compared to controls during early remodeling (up to 2 days). In contrast, inhibition of lysyl oxidase did not alter the early compaction.

LOX is indispensable for the progression of BLM-induced experimental lung fibrosis by aggravating the inflammatory response and subsequent fibrosis process after lung injury.

LOX and LOXL2 (show LOXL3 Antibodies) may play an important role in the pathogenesis of AMD (show AMD1 Antibodies). Targeting LOXL2 (show LOXL3 Antibodies) could have a broader efficacy than targeting LOX, by reducing angiogenesis and inflammation, as well as fibrosis.

LOX Antigen Profile

Protein Summary

The protein encoded by this gene is an extracellular copper enzyme that initiates the crosslinking of collagens and elastin. The enzyme catalyzes oxidative deamination of the epsilon-amino group in certain lysine and hydroxylysine residues of collagens and lysine residues of elastin. In addition to crosslinking extracellular matrix proteins, the encoded protein may have a role in tumor suppression. Defects in this gene are a cause of autosomal recessive cutis laxa type I (CL type I). Two transcript variants encoding different isoforms have been found for this gene.