Price of Afatinib Dimaleate(BIBW-2992)

Afatinib Dimaleate(BIBW-2992)is an irreversible, potent, orally bioavailable inhibitor of EGFR and HER2 with IC50's of 0.5 nM and 14 nM, respectively. BIBW-2992 is a second generation of tyrosine kinase inhibitor (TKI). BIBW-2992 is not only active against EGFR mutations targeted by first generation TKIs like Erlotinib or Gefitinib, but also against those not sensitive to these standard therapies. BIBW-2992 (Tovok) overcomes resistance of Tarceva in clinic.