Epidemiological Study in Children and Adolescents With Chronic Hepatitis B

Summary

The purpose of this study is to collect epidemiological data in children and adolescents
with chronic hepatitis B(CHB), in particular data on the prevalence of HBeAg positive
disease with associated ALT levels , active HBeAg negative disease and decompensated CHB in
the pediatric population. Family history and history of HBV transmission is essential to
assess the course of the disease and can be used to determine the best mode of treatment
This information will be used to assist with the feasibility and design of studies for the
Novartis clinical pediatric development program, as the current epidemiology of ediatric CHB
is not accurately known in Western countries or the rest of the world making pediatric
studies difficult to plan and conduct. This study forms part of the Novartis Pediatric
Investigational Plan, a post marketing approval commitment to the EMEA Pediatric Committee.

The pro-inflammatory cytokine interleukin(IL)-17 and IL-17-producing cells are important players in the pathogenesis of many autoimmune / inflammatory diseases. More recently, they have been associate...

Golgi protein 73 (GP73, also referred to as Golph 2) with 400 amino acids is a 73 kDa transmembrane glycoprotein typically found in the cis-Golg complex. It is primarily expressed in epithelial cells...

Children with rheumatic diseases often have elevated liver biochemistry. This can be triggered by medical treatment, e.g. methotrexate can induce liver injury ranging from mild to severe. Autoimmune h...

The liver is the central hub of lipoprotein metabolism. A complex relationship exists between dyslipidemia and chronic liver diseases (CLDs). Recent advances in the genetics of nonalcoholic fatty live...

Medical and Biotech [MESH] Definitions

Liver Diseases, Parasitic

Liver diseases caused by infections with PARASITES, such as tapeworms (CESTODA) and flukes (TREMATODA).

Liver Diseases, Alcoholic

Liver diseases associated with ALCOHOLISM. It usually refers to the coexistence of two or more subentities, i.e., ALCOHOLIC FATTY LIVER; ALCOHOLIC HEPATITIS; and ALCOHOLIC CIRRHOSIS.

Drug-induced Liver Injury

A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, and chemicals from the environment.

Chemical And Drug Induced Liver Injury

A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.

Liver Diseases

Pathological processes of the LIVER.

More From BioPortfolio on "Epidemiological Study in Children and Adolescents With Chronic Hepatitis B"

Relevant Topics

PediatricsPediatrics is the general medicine of childhood. Because of the developmental processes (psychological and physical) of childhood, the involvement of parents, and the social management of conditions at home and at school, pediatrics is a specialty. With ...

The Top 100 Pharmaceutical CompaniesTop 10 biotech and pharmaceutical companies worldwide based on market value in 2015
2015 ranking of the global top 10 biotech and pharmaceutical companies based on revenue (in billion U.S. dollars)
Johnson & Johnson, U.S.
74...