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Intelligent design: Engineered protein fragment blocks the AIDS virus from entering cellsIn what could be a potential breakthrough in the battle against AIDS and a major development in the rational design of new drugs, scientists have engineered a new protein that prevents the virus from entering cells. This protein is based on a naturally occurring protein in the body that protects cells from viruses, except the man-made version does not cause inflammation and other side effects at the dosages needed to inhibit AIDS. This discovery was published in the April 2011 issue of The FASEB Journal.http://phys.org/news220798587.html
BiologyThu, 31 Mar 2011 13:57:26 ESTnews220798587Heparin a key role player in allergy and inflammatory reactionsHeparin plays a key role in allergic and inflammatory reactions driven by mast cells, scientists from Karolinska Institutet in Sweden shows in an international collaboration involving colleagues from Germany and Switzerland. The study is published in the recent issue of Immunity, and sheds some new light on the biological function of heparin.http://phys.org/news217844323.html
Medicine & HealthFri, 25 Feb 2011 08:18:58 ESTnews217844323Asthma tied to bacterial communities in the airwayAsthma may have a surprising relationship with the composition of the species of bacteria that inhabit bronchial airways, a finding that could suggest new treatment or even potential cures for the common inflammatory disease, according to a new UCSF-led study.http://phys.org/news217177715.html
Medicine & HealthThu, 17 Feb 2011 15:08:44 ESTnews217177715Emotional response may predict how the body responds to stressYour emotional response to challenging situations could predict how your body responds to stress, according to research published this month in the journal Brain, Behavior, and Immunity.http://phys.org/news217159386.html
Medicine & HealthThu, 17 Feb 2011 10:03:46 ESTnews217159386Pulmonary fibrosis inhibited by pentraxin-2/SAP in research studyPromedior, Inc., a clinical stage biotechnology company developing novel therapies to treat fibrotic and inflammatory diseases, announced today the publication of collaborative research in the International Journal of Biochemistry and Cell Biology entitled, "TGF-beta driven lung fibrosis is macrophage dependent and blocked by Serum amyloid P." The research showed that human Pentraxin-2 (PTX-2), also called human Serum amyloid P (SAP), potently inhibits all undesirable pro-fibrotic pathologies driven by TGF&#946;1 and represents a novel therapeutic approach for the treatment of diseases that involve lung fibrosis, including idiopathic pulmonary fibrosis (IPF). This research validates that PTX-2/SAP can have therapeutic effects even in conditions driven by TGF&#946;1 growth factor, and builds on the body of research showing the unique role of PTX-2/SAP in activating the body's natural ability to resolve tissue damage in disease processes that cause fibrosis and inflammation.http://phys.org/news216566778.html
BiologyThu, 10 Feb 2011 13:26:55 ESTnews216566778Celiac disease and Crohn's disease share part of their genetic backgroundAn investigation has found that celiac disease and Crohn's disease, both inflammatory diseases of the gastrointestinal tract, share at least four genetic risk loci. Together, researchers from the University of Groningen, The Netherlands; the Broad Institute, USA; the Universit&#233; de Montr&#233;al and Montreal Heart Institute in Canada performed a combined meta-analysis of genome-wide data for celiac disease and Crohn's disease. This meta-analysis, published in the open-access journal PLoS Genetics on January 27, has identified two new shared risk loci and two shared risk loci that had previously been independently identified for each disease.http://phys.org/news215375003.html
Medicine & HealthThu, 27 Jan 2011 18:23:37 ESTnews215375003Red blood cell hormone modulates the immune systemNew research reveals that a hormone best known for stimulating the production of red blood cells can modulate the immune response. The study, published by Cell Press in the January 27th issue of the journal Immunity, finds that erythropoietin (EPO) has contrasting influences on infectious and inflammatory diseases and may be useful in the design of new therapeutic strategies.http://phys.org/news214758495.html
Medicine & HealthThu, 20 Jan 2011 15:08:33 ESTnews214758495Implant appears effective for treating inflammatory disease within the eyeAn implant that releases the medication dexamethasone within the eye appears safe and effective for the treatment of some types of uveitis (swelling and inflammation in the eye's middle layer), according to a report posted online today that will appear in the May print issue of Archives of Ophthalmology.http://phys.org/news213899550.html
Medicine & HealthMon, 10 Jan 2011 17:00:01 ESTnews213899550Researchers discover mechanism for signaling receptor recyclingAn international team of researchers led by Carnegie Mellon University's Manojkumar Puthenveedu has discovered the mechanism by which signaling receptors recycle, a critical piece in understanding signaling receptor function. Writing in the journal Cell, the team for the first time describes how a signaling receptor travels back to the cell membrane after it has been activated and internalized.http://phys.org/news212237468.html
BiologyWed, 22 Dec 2010 10:52:03 ESTnews212237468The heritability of Crohn's disease better understoodA University of Liege GIGA-Research Unit team has discovered new particular genetic mutations which influence hereditary predisposition to Crohn's disease, a chronic inflammatory disease of the bowel. The rare variants discovered by the researchers prove to protect against the disease and turn out not to be risk variants.http://phys.org/news211807772.html
Medicine & HealthFri, 17 Dec 2010 11:29:53 ESTnews211807772Laboratory studies show promise for new multiple sclerosis treatmentSuccessfully treating and reversing the effects of multiple sclerosis, or MS, may one day be possible using a drug originally developed to treat chronic pain, according to Distinguished Professor Linda Watkins of the University of Colorado at Boulder.http://phys.org/news209311586.html
Medicine & HealthThu, 18 Nov 2010 14:06:43 ESTnews209311586Spanish scientists publish the world's largest video data bank of proteinsAfter four years of conducting intensive calculations in the supercomputer MareNostrum at the Barcelona Supercomputing Center, scientists headed by Modesto Orozco at the Institute for Research in Biomedicine (IRB Barcelona, Spain) have presented the world's largest data base on protein motions. Called MoDEL, this new database holds more than 1,700 proteins and is partially accessible through Internet to researchers worldwide. MoDEL has been developed to study the basic biology of proteins and to accelerate and facilitate the design of new pharmaceutical agents.http://phys.org/news208693953.html
BiologyThu, 11 Nov 2010 10:33:30 ESTnews208693953Asthma drug prevents spread of breast cancer: studyA drug commonly used in Japan and Korea to treat asthma has been found to stop the spread of breast cancer cells traditionally resistant to chemotherapy, according to a new study led by St. Michael's pathologist Dr. Gerald Prud'homme.http://phys.org/news208024525.html
Medicine & HealthWed, 03 Nov 2010 17:35:42 ESTnews208024525Elusive protein may lead the fight against inflammatory diseaseA husband and wife research team from Melbourne, Australia, have identified a protein that may be a key therapy for many inflammatory diseases, including those affecting premature babies.http://phys.org/news206784635.html
Medicine & HealthWed, 20 Oct 2010 09:10:45 ESTnews206784635SHIP protein identified as a B-cell tumor suppressorLymphoma is a cancer of the immune system. White blood cells divide again and again, spreading abnormally throughout the body. Lymphomas can arise from two types of white blood cells, T cells or B cells, which divide uncontrollably when the molecular mechanisms that keep them in check go awry. A new study led by Robert Rickert, Ph.D., professor and director of the Inflammatory Diseases Program at Sanford-Burnham Medical Research Institute (Sanford-Burnham), explores the roles of two enzymes, called SHIP and PTEN, in B cell growth and proliferation.http://phys.org/news206714010.html
Medicine & HealthTue, 19 Oct 2010 14:00:01 ESTnews206714010Images shed new light on inflammation (w/ Video)Researchers at the University of Calgary Faculty of Medicine are using an innovative new imaging technique to study how white blood cells (called neutrophils) respond to inflammation, and have revealed new targets to inhibit the response.http://phys.org/news206368208.html
Medicine & HealthFri, 15 Oct 2010 13:30:43 ESTnews206368208Researchers closer to development of drug to prevent deadly immune responseResearchers have isolated a molecule, small enough to be used as a drug, that can shut down a dysfunctional immune response that causes deadly hemorrhagic shock, results in delayed death of heart attack patients, promotes rejection of transplanted organs and destroys joints in patients with rheumatoid arthritis, according to a paper published in Molecular Immunology.http://phys.org/news202062565.html
Medicine & HealthThu, 26 Aug 2010 17:50:01 ESTnews202062565Cancer drug shows promise for treating a wide range of inflammatory diseasesThose looking for a new treatment for a range of inflammatory diseases like arthritis, multiple sclerosis, inflammatory bowel disease, and lupus may need to look no further than a drug already available for treating cancer. In a research report published in the July 2010 print issue of the Journal of Leukocyte Biology, Japanese scientists use mice to show that bortezomib, currently used to treat cancers that affect white blood cells, induces cell death only in harmful (active and proliferating) T cells, leaving the rest unharmed. If the results prove true in humans, it offers hope that this drugs or others similar to it might be used to treat inflammatory diseases without the side effects of current drugs that affect all T cells equally.http://phys.org/news197112050.html
Medicine & HealthWed, 30 Jun 2010 10:40:04 ESTnews197112050Endometriosis has a significant effect on women's work productivity, firstThe first worldwide study of the societal impact of endometriosis has found a significant loss of work productivity among those women who suffer from the condition, a researcher told the 26th annual meeting of the European Society of Human Reproduction and Embryology today (Monday). Dr. Kelechi Nnoaham, from the Department of Public Health, University of Oxford, UK, said that the results of this multi-centre study would help highlight the previously unrecognised plight of an estimated 176 million women around the world whose lives are affected by endometriosis.http://phys.org/news196943509.html
Medicine & HealthMon, 28 Jun 2010 11:32:02 ESTnews196943509Side effects explained: Why common drugs can lead to broken bonesNew research helps to explain why some commonly used drugs come with a serious downside: They up your odds of breaking a bone. The drugs in question, glucocorticoids (e.g. cortisone and prednisone) and the insulin sensitizer rosiglitazone work through entirely different mechanisms as therapies for inflammatory diseases and diabetes respectively, and two studies in the June issue of Cell Metabolism now show that they lead to bone loss in different ways too.http://phys.org/news195219491.html
Medicine & HealthTue, 08 Jun 2010 12:50:02 ESTnews195219491Substance in iron metabolism displays life-saving potential for inflammatory diseasesIn a surprising discovery that someday may lead to new treatments for many inflammatory diseases, University of Utah scientists found that a hormone involved in iron metabolism can save mice from deadly acute inflammation.http://phys.org/news195132492.html
Medicine & HealthMon, 07 Jun 2010 13:20:02 ESTnews195132492New imaging suites offer more diagnostic capabilities for animal health(PhysOrg.com) -- Veterinarians in the Purdue University School of Veterinary Medicine now have the ability to look for causes of lameness, neurological disorders and other conditions in horses thanks to new imaging equipment in the Veterinary Teaching Hospital.http://phys.org/news192737243.html
BiologyTue, 11 May 2010 07:10:01 ESTnews192737243Pitt pharmacologists go on a molecular fishing trip and hook prize catchScientists at the University of Pittsburgh School of Medicine went on a molecular fishing trip and netted a catch of new mediators that not only can explain how omega-3 fatty acids reduce inflammation, but also hint at novel treatments for a host of diseases linked to inflammatory processes. Their findings were published today in the online version of Nature Chemical Biology.http://phys.org/news192013677.html
ChemistrySun, 02 May 2010 13:00:08 ESTnews192013677New pathway involved in rheumatoid arthritis identifiedInvestigators from Hospital for Special Surgery have identified a pathway involved in turning off inflammation that does not work properly in people with inflammatory arthritis. The finding, reported in the April 23 issue of the journal Immunity, could lead to the development of new therapeutic approaches to treating arthritis in the future.http://phys.org/news190374292.html
Medicine & HealthTue, 13 Apr 2010 10:45:23 ESTnews190374292Finding a potential new target for treating rheumatoid arthritisBy enhancing the activity of immune cells that protect against runaway inflammation, researchers at NYU Langone Medical Center may have found a novel therapy for rheumatoid arthritis and other autoimmune diseases. In a new study published in the March 25, 2010 online edition of Science, the researchers reveal how treating these immune cells with an investigational drug wards off inflammation by holding a particular enzyme at bay.http://phys.org/news188746767.html
Medicine & HealthThu, 25 Mar 2010 14:39:59 ESTnews188746767Periodontal pathogens enhance HIV-1 promoter activation in T cellsToday, during the 39th Annual Meeting of the American Association for Dental Research, convening at the Walter E. Washington Convention Center in Washington, DC, lead researcher O.A. Gonzalez (University of Kentucky, Lexington) will present a poster of a study titled "TLR2 and TLR9 Activation by Periodontal Pathogens induce HIV-1 Reactivation." http://phys.org/news186991128.html
Medicine & HealthFri, 05 Mar 2010 05:59:13 ESTnews186991128Scientists discover cause of destructive inflammationsThe signaling molecule CD95L, known as "death messenger," causes an inflammatory process in injured tissue after spinal cord injuries and prevents its healing. This discovery was published by scientists of the German Cancer Research Center. In mice, the researchers found out that if they switch off CD95L, the injured spinal cord heals and the animals regain better ability to move. Therefore, substances which block the death messenger might offer a new approach in the treatment of severe inflammatory diseases.http://phys.org/news186833111.html
Medicine & HealthWed, 03 Mar 2010 10:05:38 ESTnews186833111Study shows novel way to study human inflammatory diseaseA new University of Colorado at Boulder study shows mice infected with the bacteria salmonella develop clinical signs consistent with a deadly and poorly understood human inflammatory disease, a finding that may lead to new therapies.http://phys.org/news186383808.html
Medicine & HealthFri, 26 Feb 2010 05:40:01 ESTnews186383808Aspirin boosts breast cancer survival rate (PhysOrg.com) -- An observational study of 4,164 women diagnosed with breast cancer showed those taking aspirin in the period after diagnosis had a much lower rate of recurrence, and a much higher survival rate than those who did not.http://phys.org/news185616128.html
Medicine & HealthWed, 17 Feb 2010 08:02:23 ESTnews185616128Early immune response needed for hit-and-hide cancer virusesRetroviruses such as HIV and HTLV-1 don't hit-and-run, they hit-and-hide. They slip into host cells and insert their own DNA into the cell's DNA, and from this refuge they establish an infection that lasts a lifetime.http://phys.org/news182717442.html
Medicine & HealthThu, 14 Jan 2010 18:51:33 ESTnews182717442