Deadpool possesses a superhuman healing factor derived from that of the mutant Wolverine that allows him to regenerate damaged or destroyed areas of his cellular structure at a rate far greater than that of an ordinary human. As such, he can regrow severed limbs or vital organs. The speed at which this healing factor works varies in direct proportion to the severity of the damage Deadpool suffers. This healing factor also affords Deadpool a virtual immunity to poisons and most drugs, as well as an enhanced resistance to diseases and an extended life span. Unlike Wolverine’s natural healing factor, Deadpool’s is mentally driven to a partial extent.
Due to the presence of this superhuman healing ability, many of Deadpool's natural physical attributes have been enhanced. Deadpool's musculature generates considerably less fatigue toxins than the muscles of an ordinary human being, granting him superhuman levels of stamina in all physical activities. His natural strength, agility and reflexes have been enhanced to levels that are beyond the natural limits of the human body. Deadpool's agility and reaction time are superior to those of even the finest human athlete.

Abilities

Deadpool is an extraordinary hand-to-hand combatant and is skilled in multiple unarmed combat techniques. He is a master of assassination techniques, is an excellent marksman, and is highly skilled with bladed weapons (frequently carrying two swords strapped to his back). He is fluent in Japanese, German, Spanish, amongst other languages.

Weapons

Deadpool employs any number of weapons depending on his current assignment. Most often he will utilize a combination of guns and blades.

Paraphernalia

Deadpool utilizes a teleportation device located in his belt to whisk him out of (and occasionally into) danger, as well as a holographic image inducer that he can use to disguise his true appearance as necessary.

Wade Wilson's early life is mostly unknown. His mother died of cancer while he was young and his father (who was in the military) was physically abusive. Wade was a deliquent in his teenage years, possibly to spite his father. However one night while drinking with his friends his father attempt to take him out of the club one of his friends stole Wade's Fathers handgun and killed him. Following a brief stint of military service, Wade began his mercenary career while still in his late teens. Accepting assassination jobs only against those whom he felt deserved death, he made a habit of using plastic surgery and technology to take on a new identity whenever he failed an assignment. Many years later Deadpool's nemesis T-Ray accused Deadpool of killing his wife and stealing his identity after a failed mission, but Deadpool's restored memories revealed this to be a lie; in T-Ray's account Wade was wearing his Deadpool costume, which he didn't have in till after he joined Weapon X.

Little is known of Wilson’s subsequent mercenary activities. At one point he was active in Tangier, Morocco, where he romanced a woman named Francie. When this relationship soured, he traveled throughout Asia, and was hired in Japan by a crimelord, the Boss, to infiltrate a sumo-wrestling ring owned by a rival criminal, the Oyakata. Wilson spent three years as a wrestler under the Oyakata’s tutelage and became romantically involved with his mentor’s daughter, Sazae. When the Boss finally ordered the Oyakata’s murder, Wilson refused to complete his assignment, allegedly the first time he had ever done so, and relocated to the United States.

In America, Wilson met and fell in love with teenage prostitute Vanessa Carlysle, with whom he shared dreams of a better life. Wilson was subsequently hired by Middle Eastern interests to assassinate a blind British government operative named Althea, also known as Blind Al, but upon arrival at the Zaire base where she was stationed, he killed everyone except for Al who had fled. Wilson’s employers sought vengeance for his failure by targeting Vanessa, who was rescued by Zoe Culloden, an employee of the interdimensional firm Landau, Luckman, Lake, and LeQuare. Culloden was keeping Wilson under surveillance, believing he was destined to play a vital part in a potential threat to the world.

Learning that he had contracted cancer, Wilson broke up with Vanessa rather than force her to remain with a terminally ill man. In Canada, he was offered hope in the form of Department K, a special weapons development branch of the Canadian government. Wilson became a test subject in Department K’s branch of the joint U.S./Canadian superhuman enhancement project, the Weapon X Program; his cancer was temporarily arrested via the implantation of a healing factor derived from another Department K agent, the mutant adventurer Wolverine. Wilson was active in a covert field unit alongside the near-invulnerable Sluggo and the cyborgs Kane and Slayback. Vanessa herself was later affiliated with the team after having manifested mutant shapeshifting abilities, calling herself Copycat.

During one mission, Wilson killed his teammate Slayback. As a result, he was rejected from the Weapon X Program and sent to the Hospice, allegedly a government facility where failed superhuman operatives were treated. However, unknown to the Canadian government, the Hospice’s patients served as experimental subjects for Doctor Killebrew and his sadistic assistant Ajax, with the patients placing bets in a "deadpool" as to how long each subject would live. Killebrew subjected Wilson to various torturous experiments for his own deranged satisfaction. In due course, Wilson formed a semi-romantic relationship with the cosmic entity Death, who regarded him as a kindred spirit. Wilson’s emotional strength during his trials earned him the respect of his fellow Hospice patients. Then Ajax, angered by Wilson’s taunts, lobotomized one of Wilson’s friends. At Death’s prompting, Wilson killed his friend to end his suffering. However, under Killebrew’s rules any patient who killed another was to be executed; Ajax subsequently tore out Wilson’s heart and left him for dead, but Wilson’s thirst for vengeance was so strong that it jumpstarted his healing factor, regenerating his heart, although not curing his scarred body. Wilson then attacked Ajax, leaving him for dead in turn, and, taking the name Deadpool, escaped from the Hospice with his fellow patients.

Following his escape, Deadpool served for a time as an enforcer alongside the surgically altered criminal Hammerhead. He soon returned to his freelance mercenary activities, donning a costume in keeping with his new identity. At some point during his mercenary career he was employed as an assassin by Wilson Fisk, the Kingpin of crime. He also clashed with Wolverine, at that time a spy for the Canadian government. Also, at some point during these years, Deadpool caught up with Blind Al and kept her a prisoner in his home. Al’s attempts to escape only resulted in death for those whose help she sought, leaving her no choice but to resign herself to captivity.

Some years after escaping the Hospice, Deadpool, perhaps seeking compensation for the injuries inflicted upon him by Killebrew, returned to the Canadian government and was treated by Doctor Walter Langkowski, the bestial Sasquatch of Canada’s super-team Alpha Flight. Deadpool soon found government work unsuited to his temperament, and he abandoned this endeavor. Hired by the criminal genius known as the Wizard, Deadpool at first went to the wrong address and received a job impersonating the criminal Hobgoblin. When again contacted by the Wizard, he joined with fellow criminals the Taskmaster and the Constrictor in a short-lived version of the Frightful Four. When this plan also failed, Deadpool sought to reclaim his position as the Kingpin’s assassin, only to be challenged by fellow assassin Bullseye. Deadpool began frequenting the mercenary hangout called the Hellhouse, where the diminutive Patch issued assignments. There he clashed with T-Ray, a sorcerer and assassin to whom he took an immediate dislike. He subsequently found employment with the time-traveling arms merchant Tolliver, in whose service he was reunited with Sluggo and Copycat. Unbeknownst to Deadpool, Tolliver subsequently sent Copycat to impersonate another mutant mercenary, Domino. Deadpool also recruited a man named Weasel to act as his weapon supplier, and the two became fast friends.

After some time in Tolliver’s service, Deadpool was sent to kill Cable, the mutant soldier from the future who was in fact Tolliver’s father and in whose company Copycat was impersonating Domino. However, Deadpool met defeat at the hands of Cable and his new charges, the young mutants in training known as the New Mutants. When Cable reorganized the New Mutants as X-Force, Tolliver was seemingly slain in battle with them, setting off a search by his various mercenaries for the advanced technology he had left behind. Deadpool’s participation in the search was interrupted by the surprising interference of Slayback, who had cybernetically reconstituted himself after being slain by Deadpool and was eager for revenge. In the course of the ensuing battle, Copycat was gravely injured, and Deadpool sacrificed part of his healing ability to save her life.

Deadpool subsequently helped X-Force member Siryn against the unstoppable Juggernaut and her uncle, Black Tom Cassidy, who had forced Killebrew into their service. Deadpool developed a strong attachment to Siryn, who only partially returned his feelings. Unsure of his worthiness, Deadpool sought out Copycat, only to find she was now dating Kane. Deadpool fought both Kane and Wolverine, who had been sent to check on Kane by a mutual friend. Deadpool was subsequently abducted by information brokers seeking a cure for the Legacy Virus but was rescued by Wolverine and the mutant mercenary Maverick.

Soon afterward, Deadpool was approached by Zoe Culloden of the rechristened Landau, Luckman, and Lake who believed he was destined to be the Mithras, one who would help usher in a golden age for Earth. Skeptical, Deadpool turned her away, only to be hit with a string of personal failures, including the alienation of Weasel and Blind Al. Hoping to turn over a new leaf, he found that killing was not so easily left behind when, at the behest of the ghosts of his former Weapon X inmates, he killed Ajax. He hoped to move forward by accepting Culloden’s offer, only to be dismayed when he learned that his destined role was to kill Tiamat, a potential threat to the arriving “Messiah.” Deadpool instead killed the Messiah when he learned that it brought not true peace but mindless bliss instead.

Having lost his optimism about bettering himself, Deadpool returned to his mercenary life. Troubled by recent events, he sought the counsel of deranged psychiatrist Doctor Bong, who advised him to work out his difficulties in a fight with Wolverine. The fight indeed cleared Deadpool’s mind, but his psyche was dealt a stunning blow by the resurrection of Mercedes Wilson whom Deadpool still believed to be his wife. T-Ray revealed himself not only as the one responsible for her resurrection, but also as the true Wade Wilson. The revelation did not break Deadpool’s spirit as T-Ray had hoped, for the mercenary still harbored hopes of bettering himself. Swearing vengeance, T-Ray departed with Mercedes Wilson.

Later, in the course of an assassination assignment against author Duncan Vess, Deadpool again clashed with Wolverine who had sensed something strange about Vess. The pair found themselves battling Vess’s vengeful kinsmen after the author was revealed to be a werewolf, and they parted on good terms. Weeks later, Deadpool sought medical treatment for Siryn, who had been injured in a mission with X-Force. Allying himself with the mysterious Watchtower group, Deadpool captured Wolverine in exchange for Siryn’s treatment. Siryn was cured, while Wolverine easily outfought his captors.

Seeking a new place for himself, Deadpool briefly shared an apartment with fellow mercenaries Titania and the Constrictor. However, Titania proved to be Copycat in disguise, and the apartment was destroyed by the Wizard and the Taskmaster, both seeking revenge on Deadpool. He next established a secret warehouse headquarters and took on a young sidekick who called himself Kid Deadpool, but the youth, also seeking vengeance for Deadpool’s part in his father’s death, blew up the warehouse.

Deadpool was then tracked down by the feral mutant Sabretooth and invited to join the new Weapon X Program. Impressed by Weapon X’s upgrade of his healing factor, he agreed to join, but soon found the organization’s methods to be too bloody even for him. After the death of Copycat at the hands of Sabretooth, he confronted the Director, only to have his healing factor reversed to the point where he again lost physical cohesion and died. The lingering effects of Deadpool’s healing factor upgrade resurrected him, leaving him amnesiac. A chance encounter with Weasel restored his memory, and he discovered that four other individuals had laid claim to the Deadpool name. These impostors were aspects of his own personality given form by a device called the Gemini Star, wielded by his nemesis T-Ray who had been hired by the intergalactic villain Thanos, himself enamored of Death and jealous of Deadpool’s relationship with her. T-Ray intended to manifest and extinguish every aspect of Deadpool’s personality, leaving him an empty shell; however Deadpool damaged the Gemini Star, causing his personality fragments to be absorbed into T-Ray, rendering him comatose. The better to confuse his enemy, Deadpool mocked him by claiming to be the true Wade Wilson after all.

Following an assignment against the Four Winds crime family, Deadpool gained great status as a mercenary and formed a company called DP, Inc., aided by business partner Sandi Brandenberg. His success was short-lived, however, when the Black Swan, a fellow assassin who had actually slain the Four Winds himself, sought vengeance for Deadpool’s wrongful claim. Both men were believed dead after an explosive confrontation, but the Swan’s telepathic power caused the memories and skills of both himself and Deadpool to merge in the corpse of his underling Nijo. Deadpool’s healing factor resurrected Nijo, who, injured and amnesiac, found his way to Sandi’s apartment. Sandi believed Nijo to be Deadpool and nursed him back to health. Choosing the name Alex Hayden, Nijo joined Sandi and the Taskmaster in a new mercenary endeavor, Agency X.

The Black Swan soon resurfaced, with Deadpool in tow, intending to restore all three men to their previous states. During the transfer, the Swan betrayed both Deadpool and Nijo, absorbing all of their abilities and achieving great power. With the help of his friends, Nijo broke through the Swan’s telepathic shield and defeated him, reversing the transfer. Himself once more, Deadpool declined an offer to join Agency X, returning to his solo career.

Deadpool was then hired by the One World Church to steal the Façade Virus from Sunic Pharmacopeia in Germany. The Church sought to use the virus to transform everyone into blue-skinned beings like themselves, but their plans were foiled by Cable. Deadpool and Cables DNA were merged it is unclear what is instore for Cable and Deadpool.