This study investigates the effects of Allergic Rhinitis (AR) on driving ability and memory functions. Our group has previously shown that patients suffering from AR symptoms perform less well on tasks requiring sustained attention compared to non symptomatic controls. Car driving is a typical behavior that is susceptible for changes in sustained attention and might therefore become worse under conditions when patients suffer from AR symptoms. We will compare the driving performance of untreated, symptomatic AR patients with the performance of symptomatic patients that have been treated with either a systemic AR medication (a pill) or a topical medication (nasal spray)

Standard Deviation of Lateral Position (SDLP) is the amount of "weaving" that occurs when a person is driving in a straight line on the highway and instructed to maintain a steady speed and position within the lane he/she is driving

Subjects are presented with a list of 15 words at a rate of one word/second with a pause between words of one second. Immediately following the presentation subjects are asked to recall and name as many words as possible. The total number of words recalled after three repeated presentations of the same list of words is the outcome variable

Subjects are treated with Cetirizine 10 mg after a nasal challenge with a pollen solution

Drug: cetirizine 10 mg

cetirizine 10 mg over encapsulated

Experimental: Pollen provocation with topical treatment

treatment with 25ug fluticasone furoate after a nasal pollen challenge

Drug: fluticasone furoate

nasal spray 25ug per dose

Placebo Comparator: placebo treatment after pollen challenge

Placebo treatment after a nasal challenge with pollen solution

Drug: placebo

a placebo nasal spray and placebo capsule are available for double dummy treatment

No Intervention: control condition

A placebo drug is administered after a sham nasal challenge with a pollen solution

Eligibility

Ages Eligible for Study:

21 Years to 45 Years (Adult)

Genders Eligible for Study:

Both

Accepts Healthy Volunteers:

Yes

Criteria

Inclusion Criteria:

Healthy volunteers known with Seasonal Allergic Rhinitis

Experienced drivers holding a license

21- 45 years of age

Exclusion Criteria:

Asthma or other chronic illness

current psychoactive medication

History of drug abuse

Contacts and Locations

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Please refer to this study by its ClinicalTrials.gov identifier: NCT01318681