In between, Radison coached in MLB working under Jim Riggleman — like Radison, a veteran of the Cardinal system — with the Padres (1993–94) and Cubs (1995–99).[3] From 2000–09, he was a minor league manager and roving coach for the Yankees and Cardinals. His career minor league managing record is 622–552 (.530), with two championships.[4] On November 20, 2009, he was appointed first-base coach of the Washington Nationals by newly named permanent manager Jim Riggleman.[5]

In 2012, Radison joined the Houston Astros as a special assistant in the player development department. Radison was named interim first base coach for the Astros on August 19, 2012.[6] Radison was named the Astros' assistant hitting coach in 2013.[7] From 2015–16, Radison was the hitting coach for the Corpus Christi Hooks, the Astros' Double-A affiliate.[8]