This course familiarizes students with the novel concepts being used to revamp regulatory toxicology in response to a breakthrough National Research Council Report “Toxicity Testing in the 21st Century: A Vision and a Strategy.” We present the latest developments in the field of toxicology—the shift from animal testing toward human relevant, high content, high-throughput integrative testing strategies. Active programs from EPA, NIH, and the global scientific community illustrate the dynamics of safety sciences.

From the lesson

Module 4

The first lesson in this module will explain what is the concept of read-across, why it is important for regulatory risk assessment and how it can be implement by industry in response to REACH legislation. Organotypic cultures lesson will teach you about existing in vitro cell-based models starting from simple monolayer cultures of cell lines finishing with complex combined organ-on-a-chip and human-on-a-chip approaches.