Amendola, injured while trying to make a reception in the first half of Thursday night's home game with the Arizona Cardinals, takes away quarterback Sam Bradford's most reliable target long-term for the second straight season.

Last year, on Oct. 6, the Rams placed Amendola on IR after he required season-ending surgery on his triceps.

Amendola entered Week 5 with 31 receptions, second only to the New York Giants' Victor Cruz. His 351 receiving yards were good for 8th in the NFL.

Before he left the game, Amendola made a diving 44-yard catch to set up the Rams' opening-drive touchdown. After he left, Bradford struggled to complete passes to any receiver, except rookie Chris Givens, who turned his only catch into a 51-yard touchdown.

Going forward without his safety valve, the Rams need another wideout to emerge for Bradford to help their shaky passing game.