Heat-related Illness

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Heat-related Illness

In this article

An increase in body temperature can cause symptomatic illness. Temperature alone does not define the type of heat-related illness, but does so in combination with the associated symptoms and signs. This usually comes about as a result of conditions of:

High ambient temperature

High relative humidity

Physical exertion

There is a spectrum of heat-related illness ranging from heat cramps, through heat exhaustion to heatstroke.

Because heat-related illness is largely avoidable, the most crucial point of intervention concerns the use of appropriate prevention strategies by susceptible individuals and their carers. Knowledge of effective prevention and first-aid treatment, besides an awareness of potential side-effects of prescription drugs during hot weather, is crucial for physicians and pharmacists.

Epidemiology

Incidence

The incidence is relatively low in the UK and causes around 2,000 deaths each year, mainly in the elderly. However, the incidence of heat-related deaths has been predicted to rise by around 257% by the 2050s. This increase has been partly driven by projected population growth and ageing and also by climate change.[1]

The incidence may rise when customs or beliefs cause groups of people to be exposed to the heat for long periods of time such as Hajj, the annual Muslim pilgrimage in Saudi Arabia. Heat-related illness and mortality increase significantly during heat waves.[2]

Aetiology

Body heat loss is controlled by peripheral centres in the skin and organs and the central nervous system via the hypothalamus, with a greater cooling response to temperature elevation via central sensors. A temperature gradient exists between the body core and skin, which promotes heat dissipation when the core is higher than the surface.

When the core temperature increases during exercise and the skin temperature also rises as a result of the environment or internal heat production, heat dissipation is reduced. Likewise, when the body's metabolic heat production is more than heat transfer, core temperature rises and heat-related illness can occur.

Risk factors

Environmental - hot and humid.

Age - infants and elderly (particularly if bed-bound/unable to self-care).

Presentation

The physiological effects of exposure to heat can be directly heat-related (heat cramps, heat exhaustion and heatstroke) or can contribute to a worsening of respiratory and cardiovascular diseases, electrolyte disorders and kidney problems. Heat-related illnesses occur on a continuum from mild symptoms to fatalities.

Heat cramps

Body temperature often elevated, usually <40°C.

Intense thirst with muscle cramps and tachycardia.

Sweating and heat dissipation mechanisms preserved.

Normal alertness and higher functions with no neurological problems.

Heat exhaustion

Signs of heat-related illness in an individual often begin with heat exhaustion, which, if left untreated, might progress to heatstroke.

Central nervous system (CNS) function is usually largely preserved, but those experiencing heat exhaustion may experience mild confusion, irritability and poor co-ordination.

Heat dissipation is still functioning and temperature is usually <41°C.

Heatstroke

This is a combination of hyperthermia (classically defined as a core body temperature of at least 40.6°C),[3]often with loss of the capacity to dissipate heat, and CNS impairment.

Loss of ability to sweat is often a late and ominous sign.

Hyperventilation is almost invariable, with hypotension and shock occurring commonly.

If the condition progresses to a more severe form (core temperature >41.5°C) it can cause widespread damage, in particular to the brain, liver, kidney and muscle.

The thermoregulatory centre may fail so that the patient actually feels cold with dry, vasoconstricted skin, leading to a vicious cycle.

Heatstroke involves coagulopathies and cytokines, and can result in systemic inflammatory response syndrome and multiple organ dysfunction.[4]

Differential diagnosis

The history of exposure to an adverse environment ± physical exertion usually clinches the diagnosis, but sepsis and alternative causes of fever (particularly malaria if relevant area/travel history) should be considered as a cause or precipitant.

The Wilderness Medical Society has developed a set of evidence-based guidelines for the recognition, prevention, and treatment of heat-related illness. Controversy still exists over which treatment modality is most effective in the treatment of heatstroke. However, the basic premise of rapidly lowering the core temperature to about 39°C (to avoid overshooting and rebound hyperthermia) remains the primary goal.

Patients with heatstroke should be taken to a medical facility capable of critical care management of patients with multiple organ failure.

Management should begin (as always) with resuscitation ABC:

Airway protection may be necessary, as coma, fits and vomiting are common. Intubate, but avoid using suxamethonium.

Breathing should be checked and supported, as necessary.

Circulatory support is usually given with IV fluids as 0.9% NaCl or 5% dextrose:

Avoid K+ containing fluids.

Gradually reduce concentration of Na+ if hypernatraemic.

If inotropes are required, try to use those with less alpha activity - eg, dopamine.

Rapid cooling - aiming for <41°C as soon as possible.

Recent guidelines recommend ice-water immersion as the superior method for rapidly lowering core body temperature below the critical levels normally found for those with exertional heatstroke.

Evaporative and convective cooling using a combination of cool water spray with continual airflow over the body can be undertaken for classic heatstroke.

Evaporative and convective cooling may be augmented with the addition of ice packs over the entire body to promote conductive cooling.

Strip the patient, spray with tepid water and use gentle fanning (cools at ~ 0.3°C/minute).

Complications

Prognosis

With rapid cooling, sufficient rehydration and careful management of complications survival rates for heatstroke approach 85-90% in most modern centres. However, many patients experience permanent neurological impairments or death despite these efforts.[6]

Poor prognostic indicators include:

Coagulopathy.

Lactic acidosis (in the absence of severe physical exertion).

Core temperature >42.2°C.

Coma lasting >4 hours.

Acute kidney injury.

Hyperkalaemia.

Very high transaminase level.

Prolonged period of hyperthermia.

Prevention

Education of the public about the risks of heat is extremely important. Adverse effects can often be avoided by:

Adequate hydration.

Avoiding exercising in the heat.

Acclimatisation, ie the process of repeated or increasing exposure (for example, over 1-2 weeks and with daily exercise in heat) of initially 30-60 minutes increasing to about 100 minutes at a time. During acclimatisation the body becomes more efficient in work production as well as heat dissipation through various mechanisms, including a number of changes to sweat rate, volume and composition.

Pre-cooling either by cold water immersion and the application of cooling garments or by ingesting cooled drinks has become a popular strategy for those who are going to exercise in hot environments. It has been shown to be effective for lowering pre-exercise core temperature, increasing heat storage capacity and improving exercise performance in the heat.[7]

Article Information

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