Through the reunion, Niko learns that Cherise's new boyfriend is beating her. Niko then takes her to the northernmost apartments in Northwood, just a few blocks away from the Cluckin' Bell Niko found her at. Niko approaches Cherise's boyfriend who is in the apartment courtyard. This would be leading to Niko beating and warning him to stay away from Cherise. The player can also choose to kill him, which will lead to Cherise being angry at Niko and she tells him to stay away from her. No matter the situation, she will make no further appearances in the game.

If Dwayne is alive, he calls you soon afterward and jealously asks if Niko and Cherise are seeing each other, to which Niko denies.

Trivia

Execution during Ruff Rider

If the player would finish Cherise's Random encounter, Dwayne would call Niko in regards to whether or not they are dating now. Obviously, this does not happen if the player choose to kill Dwayne before meeting Cherise. Instead Niko will say "Shit, Dwayne... maybe I should've capped Playboy instead."

If the player killed Cherise during Ruff Rider, Dwayne might call Niko and say that he saw a woman in the store that looked like Cherise, and Niko reminds him that she's dead.

Like most characters in the game, Cherise will don a unique helmet when riding alongside the protagonist on a motorbike. Her helmet is green with a white stripe along the bottom.