A review of the evidence-base for harm reduction approaches to drug use

Transcription

1 Document URL: A review of the evidence-base for harm reduction approaches to drug use Neil Hunt with contributions from: Mike Ashton, Simon Lenton, Luke Mitcheson, Bill Nelles and Gerry Stimson 1 Introduction 2 What is harm reduction? 2.1 Harm reduction principles 2.2 Drug-related harms 2.3 Criticisms of harm reduction 3 Harm reduction interventions 3.1 Needle and syringe programmes 3.2 Methadone and other replacement therapies 3.3 Heroin prescribing 3.4 Depenalisation and the harms associated with criminal penalties for drug use 3.5 Information, Education and Communication 3.6 Safer injecting and other drug consumption rooms 3.7 Pill testing and allied warning systems 3.8 Motivational interviewing 4 Conclusions 5 References Acknowledgement - The findings regarding heroin prescribing are abridged from Stimson G and Metrebian M (forthcoming 2003) Prescribing heroin what is the evidence? Joseph Rowntree Foundation. 1 Introduction Harm reduction is a term that is used to refer both to a set of general principles used to underpin policies concerning the way that societies respond to drug problems and, simultaneously, to some specific types of intervention, such as needle and syringe programmes and methadone treatment, which are often seen as being synonymous with harm reduction. This overview addresses both understandings of harm reduction and summarises its key principles before going on to consider the strength and nature of the evidence of the effectiveness of various forms of harm reduction intervention. In doing so, some consideration is also given to criticisms of harm reduction that are occasionally encountered. 2 What is harm reduction?

2 In essence, harm reduction refers to policies and programmes that aim to reduce the harms associated with the use of drugs. A defining feature is their focus on the prevention of drug-related harm rather than the prevention of drug use per se. One widely-cited conception of harm reduction distinguishes harm at different levels - individual, community and societal - and of different types - health, social and economic (Newcombe 1992). These distinctions give a good indication of the breadth of focus and concern within harm reduction. When considering a definition of harm reduction, it is notable that several terms are used somewhat interchangeably; these include risk reduction, harm reduction and harm minimisation. In distinguishing these, Strang (1993) clarifies that it is harm that should be our target and, consequently, support for different proposals based on an appraisal of their impact on harm. Nevertheless, risk - the likelihood that an event causing harm may occur is sometimes used as a surrogate for harm, as harm is not always directly or easily measurable. He discusses harm minimisation as an overall goal or endpoint of policy and, by contrast, a harm reduction policy or programme as something that is essentially operational. By convention, it is harm reduction that has become the generally preferred term and, given the largely operational focus of this overview, this is the term that will be used throughout this document. Rather unhelpfully, no definitive definition of harm reduction exists. A number of definitions have nevertheless been offered (for example Newcombe 1992; CCSA 1996; Lenton and Single 1998; Hamilton, Kellehear & Rumbold, 1998). The term came into use at least as long ago as 1987 (Newcombe 1987) and its principles can be traced back much farther in publications such as that of the Rolleston Report (1926), which adopted an approach to opiate dependence that included the possibility of medically maintaining the addict: a principle which underpinned the British System for some 50 years or so (Stimson and Oppenheimer 1982; Strang and Gossop 1996). As its name suggests, harm reduction is concerned with reducing the harms that can accompany drug use and is sometimes contrasted with approaches that prioritise prevention of drug use and a rigid zero tolerance enforcement of drug prohibition; sometimes characterised as the war on drugs approach (Lenton and Single 1996; Drugs and Crime Prevention Committee, Parliament of Victoria 1999). In practice there is more convergence between countries that are associated with harm reduction and those that are more associated with a war on drugs than is often acknowledged. Globally, drug prohibition is universal, but with differences in the way that it is implemented (see section 3.4 Depenalisation). Similarly, primary prevention efforts to discourage the use of drugs by young people have remained a feature of the drug policy of countries that have been most strongly associated with the harm reduction approach such as The Netherlands, Australia, Canada, Germany, Switzerland and the United Kingdom. Conversely, treatments such as methadone maintenance that are firmly located within a harm reduction framework are widely available within the USA, which nevertheless continues to oppose needle and syringe programmes at the federal level. Historically, the main stimulus to the development of harm reduction policies and programmes was the identification of the role of injecting drug use and the sharing of needles and syringes in the transmission of HIV/AIDS. More or less in parallel, a number of countries re-examined the tension between policies that prioritised the reduction of drug use and those primarily concerned with reducing harm, drawing conclusions similar to that of the Advisory Council on the Misuse of Drugs (1988), which advised the British government that the: threat to individual and public health posed by HIV and AIDS was much greater than the threat posed by drug misuse and led to the conclusion that a hierarchy of goals should be pursued as follows:

3 1. Reduce the incidence of sharing injecting equipment 2. Reduce the incidence of injecting 3. Reduce the use of street drugs 4. Reduce the use of prescribed drugs 5. Increase abstinence from all drug use. As the quotation above suggests, it is an approach that is grounded within public health and around this time, a number of countries introduced needle exchange schemes and developed or extended their methadone treatment programmes, subsequently leading to claims that these policies have been successful in averting or reversing the epidemic spread of HIV/AIDS (Stimson 1996; Des Jarlais 1998; Des Jarlais 1999; Commonwealth Department of Health and Ageing 2002) Since the 1980s, people espousing harm reduction policies have gathered within a social movement, which was given impetus by the first Conference on the Reduction of Drug Related Harm in Liverpool, The International Harm Reduction Association (IHRA) was subsequently formed as an interdisciplinary, membership organisation to advance harm reduction policies around the world (www.ihra.net). Its membership includes public health and other health and social care practitioners, academics, policy-makers and notably - drug users, who are encouraged to participate fully within collaborative efforts to reduce drug related harm. However, although for most practical purposes there is a good deal of consensus about what harm reduction is amongst its adherents, even the IHRA has no formally adopted definition. It nevertheless suggests that the term harm reduction should be understood to mean: policies and programs which attempt primarily to reduce the adverse health, social and economic consequences of mood altering substances to individuals drug users, their families and their communities. (IHRA 2002) 2.1 Harm reduction principles Harm reduction is partly defined by a range of principles in which policies and programmes are grounded. The Canadian Centre on Substance Abuse (CCSA 1996) offers the following: 1. Pragmatism: Harm reduction accepts that some use of mind-altering substances is a common feature of human experience. It acknowledges that, while carrying risks, drug use also provides the user with benefits that must be taken into account if drug using behaviour is to be understood. From a community perspective, containment and amelioration of drug-related harms may be a more pragmatic or feasible option than efforts to eliminate drug use entirely. 2. Humanistic Values: The drug user's decision to use drugs is accepted as fact. This doesn't mean that one approves of drug use. No moralistic judgment is made either to condemn or to support use of drugs, regardless of level of use or mode of intake. The dignity and rights of the drug user are respected. 3. Focus on Harms: The fact or extent of a person's drug use per se is of secondary importance to the risk of harms consequent to use. The harms addressed can be related to health, social, economic or a multitude of other factors, affecting the individual, the community and society as a whole. Therefore, the first priority is to decrease the negative consequences of drug use to the user and to others, as

4 opposed to focusing on decreasing the drug use itself. Harm reduction neither excludes nor presumes the long-term treatment goal of abstinence. In some cases, reduction of level of use may be one of the most effective forms of harm reduction. In others, alteration to the mode of use may be more effective. 4. Balancing Costs and Benefits: Some pragmatic process of identifying, measuring, and assessing the relative importance of drug-related problems, their associated harms, and costs/benefits of intervention is carried out in order to focus resources on priority issues. The framework of analysis extends beyond the immediate interests of users to include broader community and societal interests. Because of this rational approach, harm reduction approaches theoretically lend themselves to evaluation of impacts in comparison to some other, or no, intervention. In practice, however, such evaluations are complicated because of the number of variables to be examined in both the short and long term. 5. Priority of Immediate Goals: Most harm-reduction programs have a hierarchy of goals, with the immediate focus on proactively engaging individuals, target groups, and communities to address their most pressing needs. Achieving the most immediate and realistic goals is usually viewed as first steps toward risk-free use, or, if appropriate, abstinence. Overlapping these, Lenton and Single (1998) have suggested that a policy, programme or intervention can be construed as harm reduction if: a) the primary goal is the reduction of drug-related harm rather than drug use per se; b) where abstinence orientated strategies are included, strategies are also in place to reduce the harm for those who continue to use drugs; and, c) strategies are in place to demonstrate that, on the balance of probabilities, a net reduction in drug related harm is likely to occur. And that the harm reduction approach: avoids exacerbating the harm caused by the misuse of drugs; treats drug users with dignity and as normal human beings; maximises the intervention options; (is) based on the) prioritising of achievable goals; (is) neutral regarding legalisation or decriminalisation; and, distinct from a war on drugs. Harm reduction principles such as pragmatism, with its focus on immediate, achievable goals are routinely applied to many causes of harm. In this sense the harm reduction approach is no different to the way that risks are routinely managed in many different realms of human activity. Despite the injuries, environmental impact, pollution and death toll associated with motoring, its elimination is not seen as realistic because people depend on their vehicles and, realistically, will not relinquish them. Speed limits, emission controls, seat belt and crash helmet laws can all be understood as harm reduction strategies to reduce the risks and harms of motoring. Harm reductionists hold the view that the use of drugs has been an enduring feature of human societies and that, however desirable it may be, a drug free world is an unrealistic objective, the exclusive pursuit of which can impede practical, achievable measures that reduce the burden of harms such as the disease and premature death that sometimes accompany drug use. Where it seems the most feasible way to reduce harm, harm reductionists view abstinence

5 as a valid and legitimate goal and interventions to promote abstinence are generally thought of as a special subset of harm reduction (IHRA 2002). Little distinction is made between drugs that are currently legal in most parts of the world from those that are largely illegal. The International Harm Reduction Association proposes that harm reduction should be understood to encompass alcohol, tobacco, prescribed and illicit drugs and volatile substances (IHRA 2002). In this sense, programmes that result in both abstinence and more controlled drinking each have a place within harm reduction (Heather 1993: 180) as do measures such as drink driving campaigns, guidance as to safer levels of consumption and regulations requiring labelling that displays the volume of alcohol contained in alcoholic beverages. Similarly, measures that aim to reduce tar inhalation associated with nicotine dependence and tobacco smoking e.g. low tar cigarettes or nicotine replacement patches or gum, can also be understood as harm reduction measures. Despite the universal way in which harm reduction principles can be applied to legal and illegal drugs, the focus within this overview primarily concerns those drugs that are prohibited by national legislation developed to comply with the Single Convention on Narcotic Drugs (1961), the Convention on Psychotropic Substances (1971) and the United Nations Convention against the Illicit Traffic in Narcotic Drugs and Psychotropic Substances (1988). 2.2 Drug-related harms The United Nations Office for Drug Control and Crime Prevention estimate that about 185 million people consume illicit drugs (annual prevalence ) including 147million cannabis users, 33 million amphetamine users, 13 million cocaine users, 7 million ecstasy users and 13 million opiate users, of whom about 9 million use heroin (UNODCCP 2002). Harm reduction is overwhelmingly concerned with the deployment of effective interventions relating to all harms associated with this use. There is little evidence that effective interventions exist, which can exert a primary prevention effect on illicit drug use (WHO 2002). Consequently, although many harm reductionists would regard primary prevention as a compatible goal, there is generally an emphasis on more immediate, achievable goals relating to the many harms associated with drug use, of which some of the more important are listed here. HIV/AIDS It is estimated that 42 million people are currently living with HIV/AIDS of whom 5 million became newly infected in Over 3 million people died of AIDS in 2002 (UNAIDS/WHO 2002). Injecting occurs in something like 135 countries and it is estimated that there are nearly 3 million injecting drug users with HIV infection i.e. 5-10% of all infections globally, many of which are attributable to sharing injecting equipment (Kroll 2002). Alongside transmission of HIV through shared needles and syringes, sexual transmission probably plays a significant role people who inject (Kral et al 2001; Strathdee et al 20021). Within this overall picture, substantial HIV epidemics are occurring among populations of injecting drug users such as those within China, India, Nepal, Myanmar, Indonesia, the Russian Federation and many of the Central Asian Republics. The widespread sharing of needles and syringes among people who inject also favours the rapid spread of HIV within other populations where prevalence has historically been lower, such as within Bangladesh, Vietnam and the Balkans. In Latin America, the spread of HIV through the sharing of injecting drug equipment is of growing concern in several countries, notably Argentina, Brazil, Chile, Paraguay and Uruguay, the northern parts of Mexico, Bermuda and Puerto Rico. Against this bleak background, a noteworthy success is the vigorous prevention programme in Brazil, which has led to a reversal of the spread of HIV among IDUs (UNAIDS/WHO 2002; UNAIDS 2002) and embraces harm reduction principles. Viral Hepatitis

6 Other than HIV, many other blood-borne viruses can be transmitted through sharing injecting equipment. Hepatitis B and C are currently regarded as the most important of these because of their widespread prevalence and impact on health. Globally, about 170 million people are estimated to have hepatitis C (WHO 1999). In developed countries about 90% of people infected with C are former or current injecting drug users (WHO 2000). Between 50-90% of people who become infected fail to clear the virus and develop a chronic infection, with a consequent risk of developing liver cirrhosis and liver cancer and the corresponding social and economic costs. By contrast, only about 5% of people infected with Hepatitis B develop chronic liver disease, although the consequences are equally serious for those who do. Unlike hepatitis C, which is not commonly transmitted sexually, hepatitis B is readily spread through sexual contact. People with hepatitis B are also at risk of co-infection with hepatitis D, which cannot be acquired independently. In general, co-infection with different viruses and re-infection with different strains or subtypes of the same virus worsen the person s outlook. Local and systemic bacterial infections Besides blood-borne viruses such as HIV, hepatitis B and hepatitis C, bacterial infections are also common among injecting drug users due to poor injecting hygiene or the use of contaminated drugs. Local infections such as abscesses and cellulitis are common especially among populations with poor access to sanitation, such as the homeless. Endocarditis, septicaemia and outbreaks of botulism, tetanus and other clostridial infections also are also known among IDUs (see section 3.7). Overdose Among young adults, overdose is among the leading causes of premature death in many countries. Within the European Union, death rates more than doubled between 1985 and 2000 and currently acute drug related deaths occur annually (EMCDDA 2002b). In 1999, 958 deaths in Australia were attributed to opioid overdose and estimates indicate between 12,000 21,000 non-fatal overdoses occur in Australia every year (Ministerial Council on Drug Strategy 2001). The use of cocaine, ecstasy, methamphetamine and other amphetamine-type-stimulants can all precipitate life threatening, and sometimes fatal, emergencies. Dependence Heroin dependence is increasing in many countries. By 2000, 76% of countries and territories reported to the UN that they had problems with heroin use. Heroin dependence is a major public health problem with an elevated risk of illness and of death, and has high social and criminal costs. Heroin is the most frequently used drug among people seeking treatment for drug problems in Europe, Asia, and Australia, and is second to cocaine in North America (UNDCP 2000). Heroin use is increasing in East Europe, Central Asia and Africa (UNODCCP 2002). Cocaine use has decreased in the USA, but is increasing in South America, Africa and Europe (UNODCCP 2002). Other physical and mental health problems Drug dependence and infections associated with injecting contribute to general physical debilitation and lowered immunity, which in turn increases vulnerability to infections such as pneumonia and tuberculosis, with respiratory problems particularly affecting people who inhale their drugs e.g. crack smokers and heroin users who chase the dragon. Cocaine and amphetamine type stimulants are associated with drug-induced psychosis (Connell 1958; Ellison et al 1996). Accidents and aggression Driving while intoxicated drug-driving - is increasingly recognised as a problem within developed countries, and intoxication can contribute to other accidents, aggression and injuries. Although, at present, it is unlikely that any illegal drug comes close to producing

7 the burden of harm that alcohol does in this regard. Public nuisance At the community level, drug use can cause nuisance as a result of people discarding drug related litter such as used needles and syringes. Open drug scenes can affect the real and perceived safety of people who do not use drugs - as well as drug users themselves. High levels of drug use and drug dealing can contribute more generally to problems in neighbourhoods and communities with little cultural capital and high levels of poverty. Crime Reducing the acquisitive and other crime that is largely associated with dependent drug use has long been a secondary objective of treatment programmes such as those pioneered by Dole and Nyswander (1965; 1967). In some countries such as the UK and Netherlands there are signs that the emphasis on this aspect of drug-related harm has been increasing in recent years, as indicated by the introduction of compulsory and quasicompulsory treatment programmes such as SOV in the Netherlands and Drug Treatment and Testing Orders in the UK. Harms caused by criminalisation Conversely, harm reductionists also focus on the harms that arise out of the legal framework for drug control and the consequences of criminalisation, such as disenfranchisement and exclusion from housing and education and the health and social impact of imprisonment. 2.3 Criticisms of harm reduction Harm reduction is not without its critics. Despite the fact that it is an approach grounded within public health, for which a considerable evidence base now exists, there remain people with reservations about a) its effectiveness, b) its effects and c) its intentions Harm reduction does not work In terms of harm reduction s effectiveness, the rest of this document provides an overview of this. It is necessarily brief and selective, due to the constraints of space, but it highlights the main features of the present evidence-base and should identify the main or most important evidence in each area that is considered. It identifies some areas where this is strong, others where it is weaker or equivocal, and draws attention to several areas where further research is desirable. This constitutes the argument about its effectiveness. It will be for the reader to judge what this says about whether, or in what ways, harm reduction works. The main limitations of the current evidence are also clearly laid out Harm reduction keeps addicts stuck Concerns regarding harm reduction s effects include the anxiety that deploying a harm reduction approach may enable drug use and keep people stuck within a pattern of addiction from which they would otherwise escape, perhaps after hitting a rock bottom from which harm reduction protects them. This is probably best evaluated with reference to the literature regarding methadone maintenance treatment (discussed in more detail within section 3.2). Methadone maintenance treatment has been evaluated against various drug free alternative treatments including placebo medication, offers of drug-free treatment, detoxification and waiting-list control. It consistently performs better at retaining people in treatment and reducing heroin use: to which critics might respond And so it should, if drug users are being given drugs. However, there is also evidence that it

8 prevents HIV infection, reduces mortality, reduces crime and is cost-effective: outcomes that are rarely demonstrable from other treatments within a field where, regrettably, little is as effective as one would like It encourages drug use Another possible effect is that, somehow, harm reduction encourages drug use. The rationale behind this argument appears to be that, by assisting people who are already using drugs to remain healthier, avoid problems and stay alive, people who do not use drugs will regard drugs as safe and decide to start using drugs themselves. Harm reduction is thought to send out the wrong signal and undermines primary prevention efforts. The area where this has best been tested probably concerns needle and syringe programmes (see section 3.1). Several study have investigated the hypothesis that their introduction increases drug use and found no evidence that they do (Watters et al 1994; Normand et al 1995; Paone et al 1995). However, a problem with any research into this question is that drug use is itself a dynamic phenomenon, that will independently increase and decline over time. Attributing causation or disproving it is difficult for both its critics and advocates. Nevertheless, the view that harm reduction may encourage drug use seems to underestimate the complexity of the factors that shape people s decisions to use drugs (for example see Barnard and McKeganey 1994). The implication is that, by holding a discourse with people who are using drugs about how they might limit harm and reduce their exposure to risk, non-users may learn of this, or see harm reduction services and be encouraged to try drugs. This seems to ignore the fact that a fundamental feature of the harm reduction discourse is its emphasis on harm. Whilst harm reductionists believe that this can be reduced in various ways, they would rarely claim that it can be completely avoided as our experience globally with legal drugs makes abundantly clear. Thus, the basic harm reduction message is that all drug use is potentially harmful, but that the harms can, to some extent, be constrained Harm reduction is a Trojan horse for drug law reform Finally, some people consider that harm reduction s underlying intention is to achieve drug law reform and promote the legalization of drugs. It is an undeniable fact that some advocates of harm reduction are also advocates of drug law reform and the creation of some form of legal, regulated market, for some or all drugs that are currently proscribed and, effectively, unregulated. Equally, many harm reductionists would oppose such developments. Yet others would reject dealing with drugs within the criminal law but retain civil penalties for drug use. There is no consensus on this issue among harm reductionists. Some harm reductionists would, and do, argue that public policy regarding drugs - including the prevailing system of drug prohibition - should be subject to a utilitarian appraisal that evaluates the costs and benefits of prohibition and bases policy upon the evidence of what works best. This somewhat glosses over the considerable difficulties of generating good evidence in this area; although there is a developing and instructive evidence base concerning depenalisation policies, primarily with reference to cannabis, which is summarised in section 3.4. However, some of the most prominent statements of harm reduction s principles are explicit about harm reduction s neutrality regarding legalisation or decriminalisation (CCSA 1996; Lenton and Single 1998). The critic might construe these as weasel words that disguise harm reductionists true intentions. However, a different interpretation can be derived by looking at the origins of the harm reduction movement, which emerged as a response to a global crisis of HIV infection among people who inject. Harm reduction retains this overall priority within a world in which a number of epidemics of HIV infection are simultaneously evolving in Asia, North and South America, Africa, Oceania and Europe. Part of any high quality response to this ongoing health crisis is for a

9 broad coalition of people from across different disciplines to collaborate effectively. This collaboration therefore encompasses a range of people including crucially - drug users along with public health specialists, drug treatment workers, doctors, nurses, social workers, teachers, community activists, youth workers, politicians, parents, academic researchers, civil servants (as well as drug law reformers), who try to work together to reduce the harms that arise when people use drugs. 3 Harm reduction interventions 3.1 Needle and syringe programmes Arguably, programmes for needle and syringe exchange are more readily associated with the harm reduction approach than any other type of intervention. The role of needle sharing in the transmission of blood-borne viral infections such as hepatitis B among injecting drug users (IDUs) had been known since at least the 1970s (Howard and Borges 1971). However, it was the spread of HIV/AIDS within populations of injecting drug users in the 1980s that prompted the widespread introduction of needle and syringe programmes (NSPs) - commonly referred to as needle exchanges or syringe exchange schemes - within a number of industrialised countries across Europe, Australia and in parts of North America (Gibson et al 2001) and, more latterly, within a number of developing and transitional countries (Ball et al 1998; Bastos et al 2000; Commonwealth Department of Health and Ageing 2002). Early HIV epidemiology identified the crucial role of needle and syringe sharing for viral transmission between IDUs (for example Chaisson et al 1987; van den Hoek 1988). This almost certainly remains the single most important risk factor for transmitting blood borne-viruses. When illicit drugs are prepared for injection they are typically mixed in powdered form with water before being cooked up in a cooker or spoon. Often they will be filtered through a cotton or cigarette filter before being drawn up for injection. The sharing of such paraphernalia has been identified as a further potential risk factor for viral transmission (Koester, Booth and Wiebel 1990). Consequently, some programmes also distribute other equipment, such as sterile wipes, cookers, filters and sterile water to discourage their re-use. Furthermore, some practices used to divide drugs between two or more people ( frontloading or backloading ) may also be implicated in the spread of blood-borne viruses as they enable infections to be passed from one syringe to another (Grund et al 1991; Jose et al 1993; Hagan et al 2001). NSPs provide a point of contact that enable these practices and a wide range of other health matters to be discussed. The primary goal of NSPs is therefore to prevent the transmission of HIV/AIDS and other blood-borne viral infections that are spread between IDUs through the sharing of injecting equipment. Additionally, NSPs aim to limit sexual transmission of HIV between IDUs as well as to the wider, non-injecting population (Moss 1987). The core services provided by exchanges aim to increase the number of syringes in circulation, and encourage their return and safe disposal, so that each syringe is used fewer times, thereby reducing the chances of viral transmission. Alongside the distribution of needles and syringes, NSPs also use contacts with IDUs to increase their impact by: communicating with IDUs to provide information and education such as how best to disinfect used syringes/needles; providing easier access to addiction treatment, health and social services; and, using outreach methods to make contact with hidden populations. (World Health Organisation 1998) NSPs have many different forms, and are shaped by the local and national context in which they occur. For example, a national survey of NSPs in the UK identified the following types, often coexisting and complementing each other within a given locality: pharmacy exchange schemes, dedicated (i.e. stand-alone) syringe exchanges, exchanges

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The Adverse Health Effects of Cannabis Wayne Hall National Addiction Centre Kings College London and Centre for Youth Substance Abuse Research University of Queensland Assessing the Effects of Cannabis

Heroin Heroin is an opiate drug that is synthesized from morphine, a naturally occurring substance extracted from the seed pod of the Asian opium poppy plant. Heroin usually appears as a white or brown

Drugs and Alcohol in Primary Care Steve Brinksman Clinical Lead SMMGP Habit is habit, and not to be flung out of the window by any man, but coaxed down-stairs one step at a time. Samuel Langhorne Clemens

Facts About Opioid Overdose How Does an Overdose Occur? Opioid overdose can occur when a patient misunderstands the directions for use, accidentally takes an extra dose, or deliberately misuses a prescription

Manchester City Council Report for Information Report to: Health Scrutiny Committee 23 October 2014 Subject: Report of: The Adult Drug Treatment System in Manchester Director of Public Health Summary The