The product of dosage compensation in female mammals is the inactive X chromosome (Xi). Xi facultative heterochromatin is organized into two different types, one of which is defined by histone H3 trimethylated at lysine 9 (H3K9me3). The rationale for this study was to assess SET domain bifurcated 1 (SETDB1) as a candidate for maintaining this repressive modification at the human Xi. The enzyme is shown to play a critical role.

Aims and scope

Epigenetics & Chromatin is a peer-reviewed, open access journal that publishes research, and reviews, providing novel insights into epigenetic inheritance and chromatin-based interactions. The journal aims to understand how gene and chromosomal elements are regulated and their activities maintained during processes such as cell division, differentiation and environmental alteration.

Efficient peer review

Rapid: our Editors-in-Chief maintain an average time from submission to a first decision of 35 days.

Expedited:we recognise that scientifically sound, high quality manuscripts are often turned away from broad-scope "high-impact" journals based on the issue of "general interest." As a specialist journal, Epigenetics & Chromatin will consider rapid publication of such manuscripts if they are submitted as presubmission inquiries together with the original peer reviewer reports, letter of rejection, and a brief rebuttal.

Journal Authority Factor = 111.5

The Journal Authority Factor (JAF) is the average h-index of a journal’s senior editors. The JAF thus complements the Impact Factor by providing a measure of the experience of journal editors as practicing scientists and authors. All manuscripts submitted to Epigenetics & Chromatin are evaluated by the Editors-in-Chief, who also recommend reviewers, evaluate reviews and make all decisions regarding acceptance, revision or rejection. Our JAF of 111.5 compares favorably with that of academic society journals, such as PNAS (59.9), and professionally edited journals, such as Nature (6.5).