Abstract:In this paper, efforts on extracting local features and building the global topology of 3D macromolecular scalar field are introduced．Base on the topological analysis，the critical points which potentially indicate the active regions are calculated．This technique is employed to construct the topolog ical and geometrical structures of the scalar field．The preliminary experiments with the protein data sets verify the feasibility of the method．

基金项目:Supported by the the National Natural Science Foundation of China under Grant Nos.60533050，60503056，60021201 (国家自然科学基金) Supported by the the National Natural Science Foundation of China under Grant Nos.60533050，60503056，60021201 (国家自然科学基金)