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Glandular plants of Thalictrum dioicum have often been misidentified as T . revolutum despite important differences, especially the leaflets having crenate versus entire lobe margins, respectively. The stamens in both T . dioicum and T . revolutum are pendulous.

Native Americans used roots of Thalictrum dioicum in various preparations to treat diarrhea and vomiting and for heart palpitations (D. E. Moerman 1986).

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