The show follows lone-wolf detective Angie Tribeca, a 10-year veteran of the Los Angeles Police Department's elite RHCU, and a squad of committed LAPD detectives as they investigate the most serious cases, from the murder of a ventriloquist to a rash of baker suicides.

Longtime sweethearts Celeste (Rashida Jones) and Jesse (Andy Samberg) married young, but are now drifting apart. After their divorce, they try to maintain their friendship while they both pursue other people.