Toxicogenomics

Information and institutions in the field of toxicogenomics.

Toxicogenomics is a scientific discipline and research area that studies how the genome is involved in responses to environmental stressors and toxicants. It combines toxicology with genomics to understand the role of gene-environment interactions in diseases, and also offers the opportunity to develop tests that require fewer laboratory animals or cause them less inconvenience

Toxicogenomics uses or combines methods and approaches from toxicology, genomics, transcriptomics, proteomics, metabolomics and other, as well as computer-assisted information technologies.

Pharmaceutical research defines toxicogenomics as the study of the structure and function of the genome under the influence of foreign substances (xenobiotics); here, toxicogenomics is a toxicological subdiscipline of pharmacogenomics. The aim is the prediction of individual reactions after the application of medicinal active substances (drugs).

The concept of toxicogenomics is by no means universally accepted; alternative terms - such as chemogenomics - have been proposed in the literature for this subject area.

The following overview contains information sources on toxicogenomics as well as facilities dealing with toxicogenomic questions.