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Abstract:

Gene therapy is treatment directed to curing genetic disease by introducing normal genes into the patients in order to overcome the effects of abnormal genes using technique of genetic engineering. The most radical approach involves applying this at the early stage in the embrayo, so that the new gene would be incorporated into the germ cells and hence will be inheritable. This approach is not considered to be safe either safe or ethical because the consequences may affect the descendants of the patients. Therefore, this review throws more light on gene therapy, its application and consequences in the developing countries.

Contribution/ Originality
This study contributes in the existing literature, in new gene therapy approach that repairs errors in messenger RNA derived from defective genes. It is now theoretically possible to cure all genetic diseases. It is now imperative that developing countries should embrace gene therapy technology.

Leboulch and Philippe, "Five year outcome of lentiviral gene therapy for human beta-thalassemia, lessons and prospects thalassemia reports," in Proceedings of the 3rd Pan-European Conference on Haemoglobinopathies and Rare Anaemias, 2013.