Following the contest, coach Jay Gruden offered some optimism about Perine's injury.

"Samaje went in and got checked for (a) twisted ankle, but looks like it's OK. Everything else was negative. Twisted ankle for Samaje," Gruden said, via the team's transcript.

This is the part of the post where we point out the Redskins were optimistic about Guice's injury in the immediate aftermath of last week's preseason game.

Perine wasn't the only Washington back to go down Thursday night. Backup Byron Marshall also left the game with an ankle injury. Gruden said Marshall was "OK" after getting an MRI. He's expected to miss two to four weeks, a source told NFL Network's Tom Pelissero.

Perine is expected to battle with Rob Kelley for early-down duties following Guice's injury. Kelley earned the start and took seven carries for 17 yards Thursday night. If Perine's injury keeps him out any significant amount of time, Kelley would get the bulk of the between-the-tackles totes to open the season.

"We're still in the process of trying to figure that out," said Thursday night when asked about his RB depth chart. "Rob Kelley and [Samaje] Perine. We wanted to get Samaje some good looks, he got hurt on his first run. Had a great run. 30-yard run but hurt his ankle. I wanted to try and get a good look at Byron and he kind of got dinged up there. Rob Kelley got a few touches and obviously, Martez [Carter] had a couple good looks. Kapri Bibbs continues to be consistent. His job is protecting, running routes and running the ball. It'll be a tough deal for us to figure that all out but we will."

3. Carolina Panthers safety Da'Norris Searcy was placed into concussion protocol after making a tackle on Miami Dolphins running back Kenyan Drake during the first half. Searcy drew a 15-yard penalty for lowering his helmet on the hit. He was examined in the sideline medical tent before leaving for the locker room.

Bills defensive tackle Kyle Williams walked off the field and left for the locker room after suffering a knee injury during the first half against the Cleveland Browns. Bills punter Cory Carter left the game with a knee injury and did not return.

5. The Seattle Seahawks had a positive update on Doug Baldwin and his ailing left knee. Pete Carroll told reporters Baldwin resumed running and the team still thinks he'll be ready for the season opener.

7. Green Bay Packers running back Jamaal Williams is "fine" after leaving last night's preseason game with a minor ankle sprain, a source told Pelissero.

After undergoing a battery of tests, Packers wideout Jake Kumerow was diagnosed with just a sprained SC joint, a source told Pelissero.

8. Philadelphia Eagles wide receiver Bryce Treggs is expected to miss a few weeks with a hamstring strain, per Pelissero.

9. Kansas City Chiefs cornerback Steven Nelson left against the Atlanta Falcons in the first quarter of Friday's game to undergo evaluation for a head injury. Linebacker Terrance Smith left in the first half with an ankle injury.