noun 1. simian virus 40; a virus of the Papovaviridae family, originally isolated from kidney cells of healthy monkeys, and important in recombinant DNA and cancer research. SV40 (ěs’vē-fôr’tē) n. A virus that causes cancers in monkeys and that is used widely in genetic and medical research. SV40 simian vacuolating virus 40

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