Incidence of adverse events according to the National Cancer Institute Common Terminology Criteria for Adverse Events version 4.0

Maximum tolerated dose defined as the highest safely tolerated dose level where at most 1 out of 6 patients experience dose-limiting toxicity (DLT) with the next higher dose having at least 2 patients out of a maximum of 6 patients experience DLT

To serve as an umbrella protocol for the ongoing NF1 clinical trialsprogram to longitudinally characterize and analyze NF1 related tumor and non-tumor manifestations, and to develop a better understanding of the biology of NF1 related manifes...

300

All

up to 100 Years (Child, Adult, Older Adult)

NCT00924196

08007908-C-0079

February 25, 2008

June 18, 2009

May 15, 2019

National Institutes of Health Clinical Center, 9000 Rockville PikeBethesda, Maryland, United States