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World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar. Best Paper Award : Dr. Muhammad Baqir MR Fakhrildin
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Abstract

DISCORDANCE BETWEEN HIP AND SPINE BONE MINERAL DENSITY USING DXA IN A SAMPLE OF IRAQI ANKYLOSING SPONDYLITIS PEOPLE

Background: Ankylosing spondylitis (AS) belongs to a family of rheumatic diseases known as spondylarthritides that characteristically cause spinal joint inflammation and bony fusion of the spine. Aim of the study: To measure the discorderance of Osteoporosis in the hip and spinal spines in ankylosing spondylitis in Iraqi people. Patients and methods: A cross sectional study of 70 ankylosing spondylitis patients were are treated with infliximab and etanercpt. All patients have assessment for bone mineral density by DXA for comparism and do another assessment for 35 participants as control. -Those 70 patients were categorized into two groups A and B. the 44 patients in a group A were treated with infliximab while the 26 patients in group B were treated with etanercept. Results: This study showed that the Discordance between spine and hip T-scores was significantly associated with ankylosing spondylitits disease (P < 0.05, table 1, figure 3). the major discordance about (15.7 %) while these in control are zero. The male gender was significantly associated with ankylosing sponfylitits disease (P<0.05). According to (BASDI) and (BASFI) scores at baseline (start of study) and after 6 months, both of (BASDI) and (BASFI) the mean of these scores at start of study and after 6 months did not show a significant differences between the two treatment groups (P > 0.05). Decrease in BASDI and DASFI scores after treatment; BASDI in Etanercept and BASFI for both treatments significantly decreased (P < 0.05). Disease duration (those 5 years) and those (> 5 years), there was no significant difference in T-scores for spine and hip. According to the age and BMI did not show a significant association with AS disease (P > 0.05). Conclusions: There is a positive Correlation between Ankylosing spondylitis and Osteoporosis in [the pelvis and spinal spines]. The patient gender, the activity of the disease and the duration of disease had a positive correlation with the development of Osteoporosis in AS.