The endomicroscopy is an adaptation of traditional optical microscopy in the digestive endoscopy. Furthermore, with the integration of a miniaturized laser confocal microscope to a videoendoscope, it's possible to study the digestive mucous by "optical biopsy". This monocentric, non randomized and prospective study uses the Intra-ductal confocal endomicroscopy for the characterization of pancreas and bile duct tumor.

The principal outcome is the percentage of successful in vivo examination according to the localisation of the stenosis. A successful examination is defined by the obtention of exploitable image for the anatomopathology. [ Time Frame: 2 days ] [ Designated as safety issue: No ]

Secondary Outcome Measures:

Study of the concordance between optical and histological biopsy [ Time Frame: 2 days ] [ Designated as safety issue: No ]

Utilisation of an intra-ductal confocal endomicroscopy during the endoscopic Retrograde Cholangio-Pancreatography

Procedure: Endoscopic Retrograde Cholangio-Pancreatography (ERCP)

Utilisation of the Intra-ductal confocal endomicroscopy to obtain any exploitable image for the anatomopathology.

Detailed Description:

Primary objective:

Obtain a tissular characterization of a biliary or pancreatic stenosis with a confocal microscope which is in direct contact of the stenosis during the Endoscopic Retrograde Cholangio-Pancreatography (ERCP).

Secondary objectives:

Compare the result of this "optical biopsy" to a conventional biopsy.

Tolerance

Eligibility

Ages Eligible for Study:

18 Years and older

Genders Eligible for Study:

Both

Accepts Healthy Volunteers:

No

Criteria

Inclusion Criteria:

Patients aged from 18 to older

Patient with an inflammatory or tumoral stenosis of bile duct or a solid or cystic tumor in the pancreas with a dilatation of the principal pancreatic canal.

Signed consent

Non inclusion Criteria:

Patient who have no indication for an ERCP

Allergy to fluorescein

Allergic rhinitis, asthma, eczema

Pregnancy, breast feeding

Patients with dialysis

Patient with severe heart failure

Patient with cirrhosis

Hemostasis failure which can induce difficulties or contraindication for the biopsy during the conventional endoscopy

Contacts and Locations

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Please refer to this study by its ClinicalTrials.gov identifier: NCT00930410