Chance... in the accommodation peculiar to sensorimotor intelligence, plays the same role as in scientific discovery. It is only useful to the genius and its revelations remain meaningless to the unskilled.

Spoken by character Homer Simpson in TV episode written by David X. Cohen, 'Lisa the Skeptic', of the animated comedy, The Simpsons (23 Nov 1997). Quoted in Kee Malesky, All Facts Considered: The Essential Library of Inessential Knowledge (2010), 201.

Fundamentally, as is readily seen, there exists neither force nor matter. Both are abstractions of things, such as they are, looked at from different standpoints. They complete and presuppose each other. Isolated they are meaningless. … Matter is not a go-cart, to and from which force, like a horse, can be now harnessed, now loosed. A particle of iron is and remains exactly the same thing, whether it shoot through space as a meteoric stone, dash along on the tire of an engine-wheel, or roll in a blood-corpuscle through the veins of a poet. … Its properties are eternal, unchangeable, untransferable.

From the original German text in 'Über die Lebenskraft', Preface to Untersuchungen über tierische Elektrizität (1848), xliii. As translated in Ludwig Büchner, Force and Matter: Or, Principles of the Natural Order of the Universe (1891), 1.

I do not think words alone will solve humanity’s present problems. The sound of bombs drowns out
men’s voices. In times of peace I have great faith in the communication of ideas among thinking men, but today, with brute force dominating so many millions of lives, I fear that the appeal to
man’s intellect is fast becoming virtually meaningless.

In 'I Am an American' (22 Jun 1940), Einstein Archives 29-092. Excerpted in David E. Rowe and Robert J. Schulmann, Einstein on Politics: His Private Thoughts and Public Stands on Nationalism, Zionism, War, Peace, and the Bomb (2007), 470. It was during a radio broadcast for the Immigration and Naturalization Service, interviewed by a State Department Official. Einstein spoke following an examination on his application for American citizenship in Trenton, New Jersey. The attack on Pearl Harbor and America’s declaration of war on Japan was still over a year in the future.

I once spoke to a human geneticist who declared that the notion of intelligence was quite meaningless, so I tried calling him unintelligent. He was annoyed, and it did not appease him when I went on to ask how he came to attach such a clear meaning to the notion of lack of intelligence. We never spoke again.

In the course of the last century science has become so dizzy with its successes, that it has forgotten to ask the pertinent questions—or refused to ask them under the pretext that they are meaningless, and in any case not the scientists concern.

It is still believed, apparently, that there is some thing mysteriously laudable about achieving viable offspring. I have searched the sacred and profane scriptures, for many years, but have yet to find any ground for this notion. To have a child is no more creditable than to have rheumatism–and no more discreditable. Ethically, it is absolutely meaningless. And practically, it is mainly a matter of chance.

We are living in an age of awesome agricultural enterprise that needs to be interpreted. We find our simple faith in science dominated by the Religion of PhDeism under the reign of Data; so narrow in people and often so meaningless in context as to be worthless to the scientific farmer.

Letter to Joshua Lederberg (19 Apr 1970), Joshua Lederberg papers, National Library of Medicine (online). Hildebrand was a response to a Lederberg's letter published in the Washington Post (18 Apr 1970) about 'Ecology Has All Requisites of an Authentic Religion.' Note that Sam Murchid claimed this term PhDeism in another context in his diaries (as seen in diaries of 1964 and others).

What is the meaning of human life, or for that matter, of the life of any creature? To know an answer to this question means to be religious. Does it make any sense, then, to pose this question? I answer: The man who regards his own life and that of his fellow creatures as meaningless is not merely unhappy but hardly fit for life.

What is the meaning of human life, or of organic life altogether? To answer this question at all implies a religion. Is there any sense then, you ask, in putting it? I answer, the man who regards his own life and that of his fellow creatures as meaningless is not merely unfortunate but almost disqualified for life.

Referring to speculations (on “Not as We Know It” alien lifeforms) made in the total absence of evidence. In 'Fifty Million Big Brothers', The Magazine of Fantasy and Science Fiction (Nov 1978), 55, No. 5, 86.

In science it often happens that scientists say, 'You know that's a really good argument; my position is mistaken,' and then they would actually change their minds and you never hear that old view from them again. They really do it. It doesn't happen as often as it should, because scientists are human and change is sometimes painful. But it happens every day. I cannot recall the last time something like that happened in politics or religion.
(1987) -- Carl Sagan