Kansas coach Bill Self talks with an official during the first half of an NCAA college basketball game against Iowa State on Saturday, Feb. 13, 2010, in Lawrence, Kan. Self entered the game looking for his 400th career win. (AP Photo/Orlin Wagner)— AP

Kansas coach Bill Self talks with an official during the first half of an NCAA college basketball game against Iowa State on Saturday, Feb. 13, 2010, in Lawrence, Kan. Self entered the game looking for his 400th career win. (AP Photo/Orlin Wagner)
/ AP

Kansas forward Markieff Morris (21) is fouled by Iowa State forward Craig Brackins (21) during the first half of an NCAA college basketball game Saturday, Feb. 13, 2010, in Lawrence, Kan. (AP Photo/Orlin Wagner)— AP

Kansas forward Markieff Morris (21) is fouled by Iowa State forward Craig Brackins (21) during the first half of an NCAA college basketball game Saturday, Feb. 13, 2010, in Lawrence, Kan. (AP Photo/Orlin Wagner)
/ AP

LAWRENCE, Kan. 
Xavier Henry and Tyshawn Taylor fueled a 14-0 run that turned a tight game into the laugher that everyone expected, and No. 1 Kansas romped past Iowa State 73-59 Saturday night for coach Bill Self's 400th career victory.

Self, who has coached fewer than 17 full seasons and spent the week playing down the milestone win, was given the game ball and a huge ovation right after the buzzer.

Marcus Morris and Craig Alerich each had double-doubles for the Jayhawks (24-1, 10-0), who hold a commanding three-game lead with six games to go and seem virtually assured of their seventh consecutive Big 12 championship.

It was also their 56th straight victory at home, the second-longest in school history and just four shy of the record set during the Roy Williams era.

Craig Brackins, who once scored 42 against Kansas and has always been tough for the Jayhawks to handle, had 18 points and 10 rebounds for Iowa State (13-12, 2-9).

The Cyclones quickly cut a nine-point halftime deficit to 38-35 on a bucket by Brackins. A moment later, Brackins hit a 3-pointer and Self called a time out with a shaky 40-38 lead.

Taylor stole the ball under the Kansas basket and gave the Jayhawks a quick bucket, and then Henry hit a 3-pointer to get the Jayhawks rolling to their 10th straight win over the Cyclones.

Marcus Morris and Aldrich each had 11 points, while Morris had 10 rebounds and Aldrich 12.

Henry, who seems to be pulling out of a freshman slump, had 16 points for Kansas, which outscored the visitors in the paint 34-14 and outrebounded them 47-37.

After Morris rebounded an Iowa State miss and Tyrel Reed popped in a short jumper to put Kansas on top 49-38, Taylor drove in and made a three-point play and Henry drilled a pair of free throws, giving the Jayhawks a 51-38 lead.

Justin Hamilton's jumper halted Iowa State's drought, but Sherron Collins made good on a 3-pointer, Cole Aldrich moved in for a dunk and Taylor hit a runner as Kansas went ahead 61-41.

Marquis Gilstrap and Justin Hamilton each had 11 points for Iowa State, which lost to a ranked team for the 20th straight time.