PRIMER

Development 2019 146: dev174706 doi: 10.1242/dev.174706 Published 15 August 2019

Summary: MEIS transcription factors are key regulators of embryonic development. This Primer surveys recent advances in determining MEIS function and discusses new insights into their role in the pathogenesis of solid cancers.

REVIEW

Development 2019 146: dev170985 doi: 10.1242/dev.170985 Published 15 August 2019

Summary: Vertebrates are an amalgam of asymmetric and symmetric structures. This Review discusses how symmetries and asymmetries can be generated alongside each other in the embryo and then maintained during growth.

Development 2019 146: dev176586 doi: 10.1242/dev.176586 Published 21 August 2019

Highlighted Article: Ganglion cell degeneration is the leading cause of irreversible blindness. A single pluripotency regulator (Klf4) is sufficient to confer to restricted progenitor cells the potency to generate these projection neurons.

Development 2019 146: dev180653 doi: 10.1242/dev.180653 Published 19 August 2019

Summary: ChIP-seq provides a genome-wide view of the binding sites of Alx1, a pivotal transcription factor in a gene regulatory network that controls skeletogenesis in sea urchins and other echinoderms.

In the interests of promoting transparency around the editorial process, Development will now be publishing a ‘Peer review history’ file alongside published papers. We hope that these files will provide additional insights into the published paper, by way of commentary from experts in the field, as well as opening up the process of peer review to interested readers.