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Anisimov is a product of the Lokomotiv Yaroslavl hockey school. He made his semi-professional debut for the organization's junior farm club, Lokomotiv-2, during the 2004–05 season before joining the senior team in the 2005–06 season. At the end of the campaign, Anisimov was drafted in the secound round, 54th overall, in the 2006 NHL Entry Draft by the New York Rangers.

On 23 January 2009, Anisimov was selected to participate in the 2009 AHL All-Star Classic in Worcester, Massachusetts, representing the PlanetUSA team. He scored one goal and assisted on two others, including the game-winner, in a 14–11 PlanetUSA victory over the Canadian All-Stars. On 1 February, Anisimov was called-up to the Rangers for the first time in his career after scoring 21 goals and 29 assists for 50 points with the Wolf Pack. He made his NHL debut on 3 February against the Atlanta Thrashers at Madison Square Garden.[1]