..For human geneticists, it is expected that Drosophila studies will provide a source of candidate genes whose human homologues can be examined for roles in mechanosensory development, function and disease...

..Fd3F cooperates with the pan-ciliary transcription factor, Rfx, to regulate its targets directly. This illuminates pathways involved in ciliary specialization and the molecular mechanism of transcription factors that regulate them...

The role of Atonal transcription factors in the development of mechanosensitive cells

..cousin of atonal (cato) encodes one such factor that is expressed widely in the developing sensory nervous system of Drosophila. However, nothing definitive was known of its function owing to the lack of specific mutations...

Multiple enhancers contribute to spatial but not temporal complexity in the expression of the proneural gene, amos

..There are a large number of methods available to perform clustering, but it is often unclear which method is best suited to the data and how to quantify the quality of the classifications produced...

..SOP recruitment is reiterative because the inductive signal comes from previously recruited SOPs...

amos, a proneural gene for Drosophila olfactory sense organs that is regulated by lozenge

S E GouldingInstitute of Cell and Molecular Biology, University of Edinburgh, United KingdomNeuron 25:69-78. 2000

..We present evidence that amos is required for olfactory sensilla and is regulated by the prepattern gene lozenge. Between them, amos, atonal, and the AS-C can potentially account for the origin of the entire PNS...

..At stage 9, however, D-six4 and tin are both expressed pan-mesodermally. At this stage, tin function is required for full D-six4 expression. This may explain the known requirement for tin in some non-dorsal cell types...

..We show that Roi can rescue the retinal developmental defect of ato1 mutants and speculate that amos substitutes for some of ato's function in the eye or activates a residual function of the ato1 allele...

..While the latter finding shows that enhancer context is also important in defining how proneural proteins interact with these sites, it is clear that differential utilization of DNA binding sites underlies proneural protein specificity...