Kusama will helm the pic from a script by Hay and Manfredi. Based on Chase Novak’s (pen name Scott Spencer) novel, Breed follows a wealthy New York couple who turn to a controversial Eastern European fertility clinic to conceive when all conventional methods fail. Ten years later, the nightmarish side effects of the procedure begin to manifest for — and in — the couple and their twin children.

Scott Frank is producing the project, which is the first under his new production deal at Fox. Hay and Manfredi also serve as producers.

Hay and Manfredi are both repped by UTA, while Kusama — who broke out with 2000’s Girlfight — is at ICM.