Before Using

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of morphine epidural injection in the pediatric population. Use of morphine epidural injection is not recommended in children.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of morphine epidural injection in the elderly. However, elderly patients are more likely to have age-related heart, stomach, or lung problems, which may require caution and an adjustment in the dose for patients receiving morphine epidural injection.

Pregnancy

Information about this morphine-epidural-route

Pregnancy Category

Explanation

All Trimesters

C

Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

Naltrexone

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Abiraterone Acetate

Acepromazine

Alfentanil

Alprazolam

Alvimopan

Amiodarone

Amisulpride

Amitriptyline

Amobarbital

Amoxapine

Anileridine

Aripiprazole

Asenapine

Atropine

Azithromycin

Baclofen

Belladonna

Benperidol

Benztropine

Biperiden

Bosutinib

Brofaromine

Bromazepam

Brompheniramine

Buprenorphine

Buspirone

Butabarbital

Butalbital

Butorphanol

Captopril

Carbinoxamine

Carisoprodol

Carphenazine

Carvedilol

Chloral Hydrate

Chlordiazepoxide

Chlorpheniramine

Chlorpromazine

Chlorzoxazone

Cimetidine

Clarithromycin

Clemastine

Clidinium

Clobazam

Clomipramine

Clonazepam

Clorazepate

Clorgyline

Clozapine

Cobicistat

Codeine

Conivaptan

Cyclobenzaprine

Cyclopentolate

Cyclosporine

Cyproheptadine

Darifenacin

Desipramine

Dexmedetomidine

Dezocine

Diacetylmorphine

Diazepam

Dichloralphenazone

Dicyclomine

Difenoxin

Dihydrocodeine

Diltiazem

Dimenhydrinate

Diphenhydramine

Diphenoxylate

Doxepin

Doxorubicin

Doxorubicin Hydrochloride Liposome

Doxylamine

Dronedarone

Droperidol

Enflurane

Erythromycin

Estazolam

Eszopiclone

Ethchlorvynol

Ethopropazine

Ethylmorphine

Felodipine

Fentanyl

Fesoterodine

Flavoxate

Flunitrazepam

Fluphenazine

Flurazepam

Fluspirilene

Fospropofol

Furazolidone

Glycopyrrolate

Halazepam

Haloperidol

Halothane

Hexobarbital

Homatropine

Hydrocodone

Hydromorphone

Hydroxyzine

Hyoscyamine

Imipramine

Ipratropium

Iproniazid

Isocarboxazid

Isoflurane

Itraconazole

Ivacaftor

Ketamine

Ketazolam

Ketobemidone

Ketoconazole

Lazabemide

Levorphanol

Linezolid

Lomitapide

Lopinavir

Loratadine

Lorazepam

Lormetazepam

Loxapine

Meclizine

Medazepam

Melperone

Mepenzolate

Meperidine

Mephobarbital

Meptazinol

Mesoridazine

Metaxalone

Methadone

Methdilazine

Methocarbamol

Methohexital

Methotrimeprazine

Methylene Blue

Methylnaltrexone

Midazolam

Moclobemide

Molindone

Moricizine

Morphine

Morphine Sulfate Liposome

Nalbuphine

Nalmefene

Nalorphine

Naloxegol

Naloxone

Nialamide

Nicomorphine

Nilotinib

Nitrazepam

Nitrous Oxide

Nortriptyline

Olanzapine

Opium

Opium Alkaloids

Orphenadrine

Oxazepam

Oxitropium Bromide

Oxybutynin

Oxycodone

Oxymorphone

Papaveretum

Paregoric

Pargyline

Paroxetine

Pentazocine

Pentobarbital

Perazine

Periciazine

Perphenazine

Phenelzine

Phenobarbital

Pimozide

Pipenzolate Bromide

Piperacetazine

Pipotiazine

Pirenzepine

Piritramide

Prazepam

Primidone

Procarbazine

Prochlorperazine

Procyclidine

Promazine

Promethazine

Propantheline

Propiverine

Propofol

Propoxyphene

Protriptyline

Quazepam

Quercetin

Quetiapine

Quinidine

Ramelteon

Ranolazine

Rasagiline

Remifentanil

Remoxipride

Ritonavir

Samidorphan

Scopolamine

Secobarbital

Selegiline

Sertindole

Simeprevir

Sodium Oxybate

Solifenacin

Stramonium

Sufentanil

Sulpiride

Sunitinib

Suvorexant

Tapentadol

Telaprevir

Temazepam

Terodiline

Thiethylperazine

Thiopropazate

Thioridazine

Thiothixene

Ticagrelor

Tilidine

Tiotropium

Tizanidine

Tocophersolan

Tolonium Chloride

Toloxatone

Tolterodine

Topiramate

Tramadol

Tranylcypromine

Triazolam

Trifluoperazine

Trifluperidol

Triflupromazine

Trihexyphenidyl

Trimeprazine

Trimipramine

Tropicamide

Umeclidinium

Verapamil

Zaleplon

Zolpidem

Zopiclone

Zotepine

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Chloroprocaine

Epinephrine

Esmolol

Gabapentin

Lidocaine

Perampanel

Rifampin

Somatostatin

Yohimbine

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

Ethanol

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

Asthma, severe or

Head injury, suspected or known or

Increased pressure in the head or

Paralytic ileus (intestine stops working and may be blocked) or

Respiratory depression (very slow breathing) or

Shock (serious condition with very little blood flow in the body)—Should not be used in patients with these conditions.