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Urticaria is a common dermatologic condition that typically presents with intensely pruritic, well-circumscribed, raised wheals ranging from several millimeters to several centimeters or larger in size. Urticaria can occur with angioedema, which is localized nonpitting edema of the subcutaneous or interstitial tissue that may be painful and warm. The intense pruritus can cause significant impairment in daily functioning and disrupt sleep. 1 Typically otherwise benign and self-limited, urticaria can be a symptom of life-threatening anaphylaxis or, rarely, indicate significant underlying disease.

Corticosteroids are generally teratogenic in laboratory animals when administered systemical-ly at relatively low dosage levels. The more potent corticosteroids have been shown to be ter-atogenic after dermal application in laboratory animals. There are no adequate and well-controlled studies in pregnant women on teratogenic effects from topically applied corticosteroids. Therefore, topical corticosteroids should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Drugs of this class should not be used extensively on pregnant patients, in large amounts, or for prolonged periods of time.

Adverse reactions are ranked under headings of frequency using the following convention:
Very common 2:1110
COmmon 2:1Jl00to <1/10
uncommon 2:1/1000 to <11100
Rare 2:111סס00 to <111000
Very rare <111סס00
Not knOwn (cannot be estimated from the available data), Immune system disorders
Not known: hypersensitivity
Skin and subcutaneous tissue disorders
Not known: skin atrophy, petechiae, ecchymosis, erythema, telangiectasia, hyperhidrosis, purpura, skin striae, hirsutism, dermatitis acneiform, lupus erythematosus-like lesions, suppressed reactions to skin tests
These effects may be enhanced with occlusive dressings. EndocrIne disorders
Not known: hypothalamic-pituitary-adrenal (HPA) axis
suppression (see Section Warnings and Precautions), manifestations of Cushing’s syndrome
Following discontinuation, recovery of HPA axis function is
generally prompt and complete.
Renal and urinary disorders
Not known: glycosuria, nephropaltry toxic
Metabolism and nutrition disorders
Not known: hyperglycaemia
Ear and labyrinth disorders
Not known: ototoxicity
General disorders and administration site conditions
Not known: impaired healing

FoxM1 (forkhead box protein M1) protein is a member of the Fox (forkhead box) family of transcription factors with known roles in regulating cell cycle progression. FOXM1 is a master regulator of cancer cell growth and is overexpressed in a majority of cancers, while its expression usually low in normal cells. Elevated FoxM1 expression is found in cancers of the liver, prostate, brain, breast, lung, colon, pancreas, skin, cervix, ovary, mouth, blood and nervous system. In addition, FoxM1 may drive tumor invasion, angiogenesis, and metastasis. For these reasons, FoxM1 is an attractive target for anticancer drugs such as doxorubicin, epirubicin and cisplatin.