Side effects of Pyrimethamine

How to use Pyrimethamine

Take this medicine in the dose and duration as advised by your doctor. Check the label before use.

How Tesunate SP Kit works

Pyrimethamine is a weak base that reaches high concentration within the malarial parasite and causes accumulation of toxic heme pigment, which kills it.

In Depth Information on Tesunate SP Kit

Expert advice for Artesunate

Do not start or continue the artesunate tablets and consult your doctor If you are allergic (hypersensitive) to artesunate.

Do not start or continue the artesunate tablets and consult your doctor you are in first 3 months of pregnancy or If you are breast feeding.

Do not drive or operate machinery after taking artesunate because you may feel sleepy.

Expert advice for Sulfadoxine

Take sulfadoxine along with food to minimize gastrointestinal side effects.

Take sulfadoxine with plenty of water to prevent crystalluria (crystals found in the urine when performing a urine test).

Avoid excessive sun exposure and wear protective clothing while taking sulfadoxine, as it may increase sensitivity to sunlight.

Seek immediate medical attention if you experience signs of rash or any other allergic reaction or folate deficiency (low level of folic acid in the body).

You will be regularly monitored for complete blood count, liver function tests, analysis of urine for crystalluria if sulfadoxine is administered for > 3 months.

Do not drive or operate any machinery while taking sulfadoxine as it may cause dizziness.

Do not take if patient is allergic to sulfadoxine or any of its ingredients.

Do not take if patients with impaired kidney or liver function, blood dyscrasias (a diseased state of blood), folate deficiency, severe allergy or bronchial asthma, G6PD deficiency.

Do not given to Children less than 2 months.

Do not given to regnant women at term and breastfeeding women.

Expert advice for Pyrimethamine

Pyrimethamine when given with sulphonamide, it should be given with folic acid (vitamin) supplement.

Do not use pyrimethamine if you are allergic to pyrimethamine or any other ingredient.

Do not take pyrimethamine if you have megaloblastic anemia due to folate deficiency.

Do not take pyrimethamine if you have kidney or liver problems; fits (seizures); depression; bone marrow problems; stomach or bowel problems (eg, malabsorption syndrome); phenylketonuria, or alcoholism.

Warnings

Special precautions for Tesunate SP Kit

Alcohol

Interaction with alcohol is unknown. Please consult your doctor.

Pregnancy

WEIGH RISKS VS BENEFITS

Tesunate SP Kit may be unsafe to use during pregnancy.

Animal studies have shown adverse effects on the foetus, however, there are limited human studies. The benefits from use in pregnant women may be acceptable despite the risk. Please consult your doctor.

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Lactation

CAUTION

Tesunate SP Kit should be used with caution during lactation

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Breast feeding should be held until the treatment of the mother is completed and the drug is eliminated from her body.

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Driving

Tesunate SP Kit may make you feel dizzy, sleepy, tired, or decrease alertness. If this happens, do not drive.

Patients may experience dizziness, or convulsions , and they should avoid driving or operating machinery.

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Kidney

UNSAFE

Tesunate SP Kit is probably unsafe to use in patients with kidney disease and should be avoided. Please consult your doctor.

Caution should be advised in patients with renal impairment.

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Liver

There is no data available. Please consult doctor before consuming the drug.