Education

Research

My research group is interested in the different pathways organisms use to translate
the genetic code, in particular with regard to the amino acid asparagine (Asn). To
translate Asn codons requires forming the adapter molecule asparaginyl-transfer RNA
(Asn-tRNA), a step essential for all of life. In nature, two distinct routes have
evolved to form this vital adapter molecule.

A number of bacteria, including known human pathogens, appear to encode both routes.
Informed by advances in biochemistry, molecular genetics, microbiology, and molecular
evolution, we are interested in determining if this is the case and if so how these
organisms use both pathways.

The work provides insight not only into the life cycles of these bacteria but also
into the evolution of the Asn decoding pathways. The research also lays the foundation
for development of new antibiotics to target these pathogenic bacteria. We are also
applying our knowledge of these pathways to expand the genetic code to incorporate
unnatural amino acids into proteins to facilitate studies on Alzheimer’s Disease and
more active anti-cancer agents.

The work has been supported by grants from the National Science Foundation and Research
Corporation. Students have the opportunity to present their research at regional,
national, and international meetings as well as publish in peer-reviewed journals.

Courses

CH 125 Chemical Principles (lecture and lab)

CH 341 Biochemistry: Macromolecular Structure & Function

CH 342 Biochemistry: Intermediary Metabolism

CH 343 Experimental Biochemistry Laboratory

CH 377/378 Senior Seminar in Chemistry and Biochemistry

SSP 100 Scribner Seminar-Coming of Age:Food, Drugs and Sex after the Biotech Revolution

Affiliations

American Association for the Advancement of ScienceAmerican Chemical SocietyAmerican Society for Biochemistry and Molecular BiologyAmerican Society for MicrobiologyCouncil on Undergraduate ResearchNew York Academy of Sciences