CV Risk Lower With Metformin in T2DM + Reduced Kidney Function

Sep 19, 2019

THURSDAY, Sept. 19, 2019 (HealthDay News) — Treatment with metformin versus sulfonylureas is associated with a reduced risk for major adverse cardiovascular events (MACE) among patients with type 2 diabetes and reduced kidney function, according to a study published online Sept. 19 in the Journal of the American Medical Association to coincide with the annual meeting of the European Association for the Study of Diabetes, held from Sept. 16 to 20 in Barcelona, Spain.

The researchers identified 1,048 MACE outcomes among metformin users and 1,394 events among sulfonylurea users (23.0 and 29.2 per 1,000 person-years, respectively) during follow-up (1.0 and 1.2 years, respectively). For metformin versus a sulfonylurea, the cause-specific adjusted hazard ratio for MACE was 0.80, yielding an adjusted rate difference of 5.8 fewer events per 1,000 person-years for metformin versus sulfonylurea use.

“This study and the results add to the limited observational evidence for the beneficial association of metformin compared with sulfonylurea and cardiovascular outcomes among those who develop reduced kidney function,” the authors write.