Vasculitis is an inflammatory disease of blood vessels characterized
by the alteration or destruction of the vessel wall. A 55 year’s old woman,
followed for diabetes and hypertension, presented to our consultation
complaining of generalized pruritic lesions, without fever arthritis or
any other systemic
manifestations. The patient reported the concept of taking Oxicam;
Brexin® for
pain of the right wrist and denies any food, drug or environnement
allergies. The physical examination showed violaceous petechial purpuric
patches, coalescing
by area, ulcerated nodular lesions extended to both lower limbs,
with presence of necrosis in center of lesions (Figure
1A). Histological examination found a perivascular inflammatory
cell, and necrosis of the vessels wall. The diagnostic of Leukocytoclastic
vasculitis was made. A treatment with colchicine was introduced,
with good improvement after two months (Figure
1B). Dermatological side effects of Brexin, are fortunately very
rare but they should be constantly kept in mind; and the clinician
should be aware of uncommon but not rare possibility that a cutaneous eruption
could evolve into a significantly more serious reaction.

Figure 1:
(A) ulcerated nodular lesions with necrotic center; and purpural maculopapular
lesions of both lower limbs; (B) evolution after two months of treatment,
with persistence of hyper pigmented scars