Quality of life in patients with multiple sclerosis in Republic of Srpska.

MedLine Citation:

PMID:
23348172
Owner:
NLM
Status:
In-Data-Review

Abstract/OtherAbstract:

Aim To estimate health-related quality of life (HRQoL) in patients with multiple sclerosis (MS), and to investigate relationship between HRQoL and selected demographic and clinical parameters. Methods In this cross-sectional study HRQoL was measured using the MS-speciic MSQoL-54 questionnaire. Neurological impairment was assessed using the Expanded Disability Status Scale (EDSS), and presence of depression and anxiety using the Hamilton Depression Rating Scale (HDRS) and the Hamilton Anxiety Rating Scale (HARS). Statistical analysis included descriptive statistics and correlation analysis. Results The results conirmed that physical disability had a signiicant impact on HRQoL. Correlations were the strongest for the domains of physical health (PH) (r=-0.718), overall quality of life (QL) (r=-0.528), satisfaction with sexual function (r=-0.493) and role limitations due to emotional problems (r=-0.493) of MSQoL- 54 scales. It was found that there were statistically signiicant correlations between composite score of PH of MSQoL-54 scale and duration of MS ( r=-0.381), employment status (r=-0.624), educational level (r=0.384), occupation (r= 0.552), and age at disease onset (r=-0.434). There were statistically signiicant correlations between anxiety and depression and low scores on a majority of MSQoL-54 subscales. Correlations were the strongest for the subscales of QL (r=-0.674), energy (r=-0.629), sexual function (r=-0.579) and PH (r=-0.573) for HARS and QL (r=-0.751), PH (r=-0.629) and satisfaction with sexual function (r=-0.612) for HDRS. Conclusion Our results indicate that HRQoL is inluenced not only by disability itself, but rather by interactions of a range of physical, psychological and social factors.