Researchers in Northern Italy performed a nested case-control study of women aged 35 to 65 beginning in 1987. They had blood samples taken repeatedly over the years. Over a 15 year period a number of women developed breast cancer. Their data and blood samples were compared to those of women who retained their health.

Vitamin B6 (pyridoxine) at higher concentrations in blood plasma was strongly correlated with lowered cancer incidence. It was connected to a decreased risk of breast cancer overall by 22%, decreased the risk of breast cancer in premenopausal women by 34%, decreased the risk of estrogen dependent breast cancer by 21%, decreased the risk of progesterone dependent breast cancer by 28%, and decreased the risk of breast cancer in women who consumed alcohol by 29%.

Vitamin B2 (riboflavin) was also connected to protection decreasing the risk of breast cancer in younger premenopausal women by 55%. The study is published June 1st, 2016 in The Journal of Nutrition.

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