The National Institute of Allergy and Infectious Diseases intends to issue a Request for Applications (RFA) for competitive supplements to currently funded NIAID grants. The RFA is expected to be published in December 2006. Proposed research must be beyond the scope of an investigator’s currently funded grant. The goal of these supplements is expand collaborative research among HIV and immunology investigators focused on B cell immunology related to the mechanism by which broadly protective neutralizing anti-HIV-1 antibodies can be induced and maintained. New research in this area is important to the development of preventive vaccines for HIV-1.