How to Join the NCI CIRB

Updated on September 25, 2010

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This article is written for clinical research sites who currently utilize a local Institutional Review Board.

The National Cancer Institute Central Institutional Review
Board (CIRB) has been established over ten years ago to try to alleviate most
of the administrative work required by local Institutional Review Boards (IRB).

All of the responsibilities of the CIRB and the local IRBs are outlined in the
NCI CIRB Handbook for local sites located on the NCI CIRB website (please find a link below this article). The
application process is also located in this handbook. Read more to learn about some of the requirements in order
to participate in the CIRB initiative...

Institutions that enroll patients into Cooperative Group
clinical trials are encouraged to apply to the CIRB by completing the NCI CIRB
enrollment form. They must meet eligibility requirements such as having their
own IRB with a Federal Wide Assurance Number. Enrollment assistance can be found on
the NCI CIRB website: http://www.ncicirb.org/

There are responsibilities required of local IRBs if an
institution chooses to utilize the NCI CIRB:

The local IRB must ensure that
research is conducted at their institution under the local requirements in the
best interest of protecting human subjects.

All local serious adverse events,
unanticipated problems, and protocol violations are managed under the local
IRB.

Local IRBs must also conduct facilitated reviews. There are
specific guidelines as to how the facilitated review must be done all stated in
the CIRB handbook.

During facilitated reviews, the local IRB reviews the
protocol and they make small changes to the consent form under local policies
and state laws and must be compliant with HIPAA regulations. Translation of the
consent form is done by the local IRB. Any significant changes to the consent
form may require full board review. If an investigator wants to enroll a
prisoner on a cooperative trial they must undergo full board review of the
protocol at their local institution.

CIRB

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