"The spread of obesity has been declared a worldwide epidemic by the World Health Organization (WHO). In fact, a new term, globesity, has been coined to describe the recent upsurge of overweight and obesity throughout the world's population. How severe is the problem? According to WHO, worldwide obesity has more than double since 1980. In 2008, 1.5 billion adults, 20 and older, were overweight [1]. Of these over 200 million men and 300 million women were obese. 65% of the world's population live in countries where overweight and obesity kills more people than underweight [1]. Furthermore, nearly 43 million children under the age of five were underweight in 2010 [1]"-- Provided by publisher.

In addition to their metabolic and endocrinologic effects, obesity and adipose tissue have now been shown to be associated with chronic low grade inflammation resulting in cellular and humoral factors of which the latter may act by endocrine, paracrine and autocrine mechanisms. These inflammatory mediators have increasingly been suggested as contributing to the obesity link to carcinogenesis and cancer promotion. Obesity, Inflammation and Cancer focuses on recent developments and cutting edge research pointing to inflammation and inflammatory factors as key mediators of this linkage. It also describes possible strategies for targeting inflammation as an approach to cancer prevention and control. Students, researchers and clinicians, especially those interested in the relation of obesity to cancer and the role of inflammation and its impact on cancer, will find this volume particularly useful. It provides important insight on the role of inflammation in cancer etiology and progression and serve as a platform for developing future research in this area.

Obesity is a risk factor for breast cancer in older women. A number of adipose-derived and obesity-related factors have been shown to affect tumour cell growth. These include adipokines, insulin, IGF-1 and oestrogens. The majority of obesity-related postmenopausal breast cancers are oestrogen-dependent. Since the ovaries no longer produce oestrogens after menopause, and that circulating levels are negligible, it is evident that it is the oestrogens produced locally within the breast adipose that are responsible for the increased growth of breast cancer cells. Aromatase is the enzyme that converts androgens into oestrogens and its regulation is dependent on the activity of a number of tissue-specific promoters.Targeting oestrogen biosynthesis in obesity may be useful for the prevention of breast cancer.Aromatase inhibitors are efficacious at treating postmenopausal breast cancer and recent studies suggest that they may also be useful in the prevention setting. However, these compounds inhibit the catalytic activity of aromatase and as a consequence lead to a number of undesirable side-effects, including arthralgia and possible cognitive defects due to inhibition of aromatase in the bone and brain, respectively. Novel therapies, such as those employed to treat obesity-associated disease, including anti-diabetics, may prove successful at inhibiting aromatase specifically within the breast.This SpringerBrief will explore all of these issues in depth and the authorsare in a unique position to write about this topic,havingextensive experience in the field of aromatase research.

This timely and clinically oriented book uniquely addresses the entire spectrum of treatment for severe obesity and diabetes. It thoroughly examines all aspects from robotic surgery to cell therapy, from the latest antidiabetic drugs to endoscopic procedures and devices, from appetite-inhibiting signals and nutrients to gastric arterial embolization. It offers objective and authoritative information for practicing professionals; not only are successful interventions discussed and updated, but cutting-edge and experimental pathways are also anticipated. Obesity is the foremost nutritional challenge worldwide. Its companion is type-2 diabetes, the most prevalent metabolic disease. Together they represent the diabesity epidemic, which is draining resources, overwhelming healthcare facilities, and impacting life expectancy and quality of life everywhere. No country has been spared, and most medical specialties have been affected. Many books focus on the surgical options for obesity and diabetes, namely bariatric and metabolic operations. Information on the clinical and pharmacological treatment is also available, conveyed by standard texts on internal medicine and endocrinology. Yet endoscopic maneuvers and prostheses, cell therapy for diabetes, and other innovative approaches are hard to come by, as conventional texts overlook such therapies. This timely publication bridges the gaps between all different therapeutic options, also covering advances in the conservative, surgical and parasurgical domains. This book will appeal to seasoned specialists, students and healthcare professionals in training alike.

"Due to the resultant health consequences and considerable increase in prevalence, obesity has become a major worldwide health problem. "Obesity and Lipotoxicity" is a comprehensive review of the recent researches to provide a better understanding of the lipotoxicity-related mechanisms of obesity and the potential for the development of new treatment strategies. This book overviews the biochemical pathways leading to obesity-related metabolic disorders that occur subsequent to lipotoxicity. Chapters examine the deleterious effects of nutrient excess at molecular level including the cellular and molecular aspects of breast cancer, resistance to leptin, insulin, adiponectin, and interconnection between the circadian clock and metabolic pathways during high-fat feeding. "Lipotoxicity and Obesity" will be a useful resource for clinicians and basic science researchers, such as biochemists, toxicologists, immunologists, nutritionists, adult and pediatric endocrinologists, cardiologists, as well as students who are thought in this field"--Publisher's description.

As a result of the rapidly growing rate of obesity worldwide, clinicians are struggling to provide the best strategies for treating obese patients with concomitant pulmonary conditions. Obesity does not simply change the epidemiology of pulmonary disease; obesity has a profound impact on the pathophysiology of common pulmonary diseases. Obesity affects the severity of asthma, response to treatment, and is likely a major modifier of the phenotype of asthma. Obesity also appears to affect response to pathogens, and as such has a major influence on response to pneumonia, and has a significant impact on outcomes pertaining to acute lung injury in the intensive care unit. Obesity and Lung Disease: A Guide to Management is the first text in the field to cover the full range of issues related to managing obese patients with pulmonary problems.

The book provides a comprehensive perspective on the subject of obesity epidemiology, pathophysiology, and management of obesity. The chapters provide a better understanding of obesity and obesity-related diseases and offer an integrative framework for individualized dietary and exercise programs, behavior modification, pharmaceutical approaches, surgery, and population interventions to reduce the growing epidemic of obesity.

Objective structured clinical examinations (OSCEs) and other exercises that utilize standardized patients (SPs) can simulate actual clinician-patient encounters with great impact. They are one of the most effective methods for training and assessing competencies across undergraduate, (post)graduate, and continuing health professions education. However, organizing such programs requires strong leadership and the collaboration of many key individuals for planning and implementation. This book, Objective Structured Clinical Exams: 10 Steps to Planning and Implementing OSCEs and other Standardized Patient Exercises, serves as a comprehensive how-to manual and addresses the need for best practice guidelines. It contains a review of relevant literature, pointers for designing OSCE cases, tips on recruiting and training standardized patients, and it describes innovative uses of standardized patients for remediation and assessment in clinical settings. Charts, graphs, and sample forms are included to make this a singular resource for any educator interested in creating or improving OSCEs and other standardized patient programs.

--v.1, The structure of the body: cells, tissues and skin; case histories and questions based on nursing care of gastro-enteritis, undernutrition and infestation ; v.2, The skeletal system and the muscular system ; v.3, The circulatory system and the respiratory system ; v.4, The digestive system and the urinary system

Using sample administrative and clinical protocols that any hospital can use, this book gives a detailed account of how to set up and run an observation unit and reviews all medical conditions in which observation medicine may be beneficial. In addition to clinical topics such as improving patient outcomes and avoiding readmissions, it also includes practical topics such as design, staffing, and daily operations; fiscal aspects, such as coding, billing, and reimbursement; regulatory concerns, such as aligning case management and utilization review with observation; nursing considerations; and more. The future of observation medicine, and how it can help solve the healthcare crisis from costs to access, is also discussed. Although based on US practices, this book is also applicable to an international audience, and contains instructions for implementing observation in any setting or locale and in any type of hospital or other appropriate facility.

This book summarizes scientific advances in our understanding of the interrelationship between obsessive-compulsive symptoms (OCS) and schizophrenia and reflects on the implications for future research directions. In addition, guidelines are provided on practical assessment, diagnosis, and treatment interventions, covering both pharmacotherapy and psychotherapy. Full account is taken of the fact that the variable clinical presentation regarding time of onset and course of OCS in patients with schizophrenia strongly suggests the need for a perspective that recognizes heterogeneous subgroups and diverse neurobiological explanations. Research-based multidimensional conceptual frameworks are accordingly provided relating to the co-occurrence of the disorders, incorporating recent epidemiological, neurocognitive, neurogenetic, and pharmacodynamic findings. Obsessive-Compulsive Symptoms in Schizophrenia has been written by an international team of experts who offer insights gained through their extensive experience. It will be an invaluable guide to this frequent and clinically important comorbidity and will be particularly useful for mental health practitioners.

"Richly illustrated and comprehensive in scope, Obstetric Imaging, 2nd Edition, provides up-to-date, authoritative guidelines for more than 200 obstetric conditions and procedures, keeping you at the forefront of this fast-changing field. This highly regarded reference covers the extensive and ongoing advances in maternal and fetal imaging in a concise, newly streamlined format for quicker access to common and uncommon findings. Detailed, expert guidance, accompanied by superb, high-quality images, helps you make the most of new technologies and advances in obstetric imaging"--Publisher's description.

Complications that arise during childbirth remain a significant challenge for all healthcare providers. Obstetric Interventions is a richly detailed text that combines traditional obstetrics with the use of innovative birthing techniques. With clear, state-of-the-art color illustrations throughout - all originally produced for this text - this book gives clear insight into the mechanisms of normal childbirth and the alternative techniques of obstetric intervention that may need to be used in the delivery room. In addition to being highly illustrated, the book is accompanied by over 50 animated simulations of obstetric interventions that are available online. These highlight the different birth mechanisms in truly unique detail and will aid understanding of anatomy and technique. Obstetric Interventions is aimed at obstetricians, obstetric trainees, and midwives. This book provides an evidence-based insight into the choices that obstetricians and midwives face every day at all stages of the birthing process.

Designed to teach you to think like a more experienced clinician, Obstetrics and Gynecology: A Competency-Based Companion, by Michael Belden, MD, places as much value on process as it does on content. This unique resource features a case-based organization that hones in on essential knowledge in obstetrics and gynecology. Its convenient pocket-sized format enables you to review the material on the go, and online access via Student Consult enhances your study of the material and exponentially boosts your reference power. Provides high-yield core information essential to rotations in a pocket-sized, portable format. Uses a color-coded system that places core information in a framework of the ACGME Core Competencies. Offers self-assessment activities throughout to promote retention and application of knowledge, including access on line to your own competency-based portfolio tools and competency-specific learning modules (Vertical Reads). Features ACGME Core Competencies enabling you to integrate evidence-based medicine, continual self-assessment, and cognizance of interpersonal skills into your daily routine. Includes features such as "Speaking Intelligently" and "Clinical Thinking" in each chapter to help you see the "big picture." Presents "Teaching Visuals"--An interactive teaching device designed to reinforce visual concepts. Equips you to perform a more in-depth review of obstetric and gynecological topics with "Clinical Entities" that link to top references in the field. Includes access to Student Consult at www.studentconsult.com, where you'll find the complete text and illustrations of the book online, fully searchable . "Integration Links" to bonus content in other Student Consult titles . Self-Assessment Competency Log . Professors Pearls that provide cases with questions and annotated answers . Vertical Reads . and much more!

"Incidences of inflammatory airway diseases are on the rise across the world. Existing therapeutic options are ineffective, unsafe, and expensive, and severe cases are nonresponsive to conventional therapy. Therefore, it is imperative that research be undertaken to discover new treatment options. Obstructive Airway Diseases: Role of Lipid Mediators discusses clinically successful and potential lipid targets that can make a difference in treating some of the most intractable disease states."--Publisher description.

This book is a comprehensive guide to occupational factors of malignant diseases. It discusses potentially work-related malignancies, in the context of exposure assessment, specific clinical and pathological features of occupational cancer and biomarkers of exposure and disease. Epidemiological data about risk ratios of the cancer in question are reviewed for various occupations and with exposure to specific carcinogens, carcinogenic mechanisms, host susceptibility factors (genetic and other) and other environmental and life-style risk factors. Aspects such as surveillance of workers exposed to carcinogens, and strategies for prevention of occupational cancer are also discussed. Occupational Cancers is aimed at oncologists, pathologists, residents in training, clinical researchers, clinicians in occupational health, epidemiologists, pulmonologists, lawyers and public health officials.

Delivering good quality, safe and effective care -- Person-centredness and long term neurological conditions -- Theoretical basis -- Occupation and long term neurological conditions -- Identifying occupational performance enablers and deficits -- Occupational therapy intervention -- Using technology to support participation -- Living with a long term condition -- Planning for the future.

"Occupational Therapy Evidence in Practice for Mental Health" provides students and practitioners with a textbook that both demonstrates and explains the application of evidence-based practice. The book contains case studies that clearly illustrate the ways in which theory, research and/or governmental guidelines can be used to inform clinical reasoning and practice. Each chapter addresses different areas of mental health and demonstrates how the occupational therapy process might be implemented for each individual and how available evidence can be used to inform this process as well as the therapist's reasoning and critical reflection. Content spans a wide range of occupational therapy practice with client cases representing a variety of diagnoses, ages and social and cultural backgrounds within an assortment of health or social care settings.

Epidermolysis bullosa (EB) is the collective term for a heterogenous group of genetic skin disorders characterised by the formation of blisters and erosions on skin and mucous membranes.This book deals with early childhood motor and perceptual development, a particular challenge for children with extremely fragile skin. Going into functional treatment, it addresses rehabilitation of hands and feet in EB patients with fusions or contractures.The authors are occupational therapists with long-term experience in the management of EB patients. In an extraordinary holistic approach, they present a combination of paediatric and functional areas of treatment.Occupational therapy tools and interventions can help alleviate a number of accompanying complications and symptoms of EB, enhance self-care, and improve quality of life in general.Due to its practical approach, this book not only serves as a unique guide for doctors and health care professionals but is also comprehensible and useful for patients.

This book a conjoint effort of ocular oncologists, general oncologists, and pathologists is a comprehensive source of authoritative information on the subject of ocular and adnexal lymphoma. It covers all aspects, including clinical features, classification, epidemiology, diagnostic evaluation, biopsy techniques, histology and molecular pathology, staging procedures, and treatment methods. Detailed information is provided on primary vitreoretinal and adnexal lymphomas and chapters are also included on rare variants such as T cell lymphoma and reactive lymphoid hyperplasia of the ocular adnexa. The emphasis throughout is on easy readability, and the layout ensures rapid retrieval of information. In order to convey fundamental concepts, numerous tables, clinical photographs, histopathologic microphotographs, and imaging studies (fluorescein and indocyanine angiograms, ultrasonograms, CT scans, and MR images) are included.

This book meets the growing demand among ophthalmologists, optometrists and orthoptists, in training and in practice, as well as visual neuroscientists, to have a clear, succinct and well-written textbook to objectively cover the subject of ocular and visual physiology. Ocular and visual physiology is a core knowledge component for these disciplines, and yet is often difficult to understand. However, this book clearly conveys the simple elegance of the relationship between structure and function that is the hallmark of understanding the physiology of the eye and visual system. Ocular and Visual Physiology - Clinical Application is essential reading for any one hoping to have a clear understanding of the subject. Students will find it a great resource to pass their exams. Each of the chapters has been independently reviewed and edited by an expert in the field with a clinical or visual scientific academic background. The text is based on the latest publications in peer-reviewed journals that are closely referenced within the body of the text.

A newly introduced companion volume to the classic Adler's Physiology of the Eye-correlates basic science and clinical management to describe the how and why of eye disease processes and the related best management protocols. Editors Leonard A. Levin and Daniel M. Albert-two of the world's leading ophthalmic clinician-scientists-have recruited as contributors the most expert and experienced authorities available in each of the major areas of ophthalmic disease specific to ophthalmology: retina, cornea, cataract, glaucoma, uveitis, and more. The concise chapter structure features liberal use of color-with 330 full-color line artworks, call-out boxes, summaries, and schematics for easy navigation and understanding. In print and online at expertconsult.com, this comprehensive resource provides you with a better and more practical understanding of the science behind eye disease and its relation to treatment.

Ocular infections remain an important cause of ocular morbidity and loss of vision, yet many are preventable or curable. Early diagnosis and prompt treatment help in the control of such infectious disorders and the prevention of blindness. There are many infectious diseases of the eye and adnexa, and knowledge of their diagnosis and management is essential to an optimal therapeutic outcome. This book provides the practitioner with the important information required to ensure appropriate diagnosis and management of ocular infectious diseases. Specific clinical signs and symptoms are outlined, and the role of specific diagnostic tests, including molecular biology techniques, is explained. All of the most common microorganisms are considered and current knowledge on the antimicrobial therapy of ocular infections is clearly summarized. Ocular Infections will be a great help to physicians as a guide to the care of patients with ocular infectious diseases.

Comprehensive, yet concise and clinically oriented, the new edition of Ocular Pathology brings you the very latest advances of every aspect of ocular pathology. From updated information on today's imaging techniques, to the implementation of genetic data to better understand disease, this esteemed medical reference book promises to keep you at the forefront of your field Take advantage of clinical "pearls" that offer you the benefits of proven strategies.Quickly reference information with help from a convenient outline format, ideal for today's busy physician. Visualize every concept by viewing 1,900 illustrations, 1,600 of which are in full color, from the collections of internationally renowned leaders in ocular pathology.

This book provides a comprehensive account of the pathogenesis, clinical features, and management of ocular vascular occlusive disorders, with the focus very much on the scientific evidence. This offers a sound basis for addressing the many controversies that surround these disorders, which collectively constitute the most common cause of visual impairment or blindness. The book is divided into two sections, the first of which addresses the basic science and encompasses vascular anatomy, blood supply and flow, and retinal tolerance time to acute ischemia. The second, clinical, section covers the presentation, clinical features, diagnosis, and treatment of the full range of vascular occlusive disorders of the retina, the choroid, the anterior segment of the eye, ophthalmic manifestations of carotid artery disease and the optic nerve. ℗ℓ In writing Ocular Vascular Occlusive Disorders, the author has drawn upon more than 55 years of experience in basic and clinical research. The book will be an invaluable source of information for general ophthalmologists, and particularly for retina specialists, neuro-ophthalmologists, and researchers. It is hoped that it will go far in rectifying the lack of in-depth scientific understanding that is the source of many misapprehensions and debates.

This well-established international series examines major areas of basic and clinical research within neuroscience, as well as emerging and promising subfields. This volume explores interdisciplinary research on invertebrate and vertebrate models of odor memory and perception, as well as human odor memory and perception. This book brings together a collection of authors that cut across model systems, techniques, levels of analysis and questions to highlight important and exciting advances in the area of olfactory memory and perception.

Recent trends in medicine have pushed many gynecologic procedures to the outpatient setting, whether in-office, in small medical ambulatory surgery centers, or in procedure rooms. Office-Based Gynecologic Surgical Procedures covers both basic and advanced procedures, from biopsy and saline ultrasound to cystoscopy. It answers the "How?", "What?", and "When?" of setting up, preparing for, and confidently performing office procedures. While appropriate training and certification in these procedures such as cystoscopy and hysteroscopy is needed, this book is an excellent resource for advice and tips on how to safely transition from the technique used in the operating room. It also provides the necessary algorithms and in-depth instructions pertinent to performing these types of procedures effectively in the office setting. A chapter on patient safety in the office is also included. Office-Based Gynecologic Surgical Procedures is ideal for established OBGYNs in practice who want to expand their range of procedures offered in-office, fellows in Women's Health, advanced nurse practitioners, recent OBGYN residency graduates, and family medicine physicians eager to familiarize themselves with women's health procedures.

Whether you're a newcomer to the ICU or a seasoned practitioner, Oh's Intensive Care Manual delivers the practical, expert answers you need to manage the conditions you see every day in the intensive care unit. This highly esteemed, bestselling medical reference book presents comprehensive detail on each topic, while maintaining a succinct, accessible style so this information can be seamlessly incorporated into your daily practice.

Despite the best efforts of many and despite landmark discoveries and experimental ingenuity, challenges in the pursuit of research related to olfactory receptors (ORs) continue to exist. In Olfactory Receptors: Methods and Protocols, experts in the field contribute chapters that serve to address these challenges. The volume consists of several sections: knowledge dissemination of ORs, theoretical assessments of OR structure and function, as well as development and use of expression systems and experimental functional analysis. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Concise and practical, Olfactory Receptors: Methods and Protocols seeks to aid researchers in furthering the knowledge of olfaction and moving us ever closer to the thrilling discoveries that will follow.

Over the last several years developing human research suggests that a component of omega-3 fatty acids, long chain ones, contribute particularly to health benefits. Omega-6/3 Fatty Acids: Functions, Sustainability Strategies and Perspectives focuses on developing information on this newly recognized key component. This volume uniquely, and for the first time, focuses on sustainability of natural sources of omega-3 fatty acids variants including long chain ones, and on ways to increase their use and availability to reduce major diseases. The authors review cardiovascular disease, neurological changes and mental health and other diseases like diabetes where long chain omega-3 fatty acids play protective roles from recent human trials. Each chapter evaluates developing information on the possible mechanistic role of long chain omega-3 fatty acids. After showing their requirement and involvement in health promotion there are reviews of various sources and ways to protect and promote them. Authors provide support for the benefits and sources of long chain omega-3 fatty acids and their increased dietary intake that reduce various physical and mental illnesses. Omega-6/3 Fatty Acids: Functions, Sustainability and Perspectives is a unique and important new volume that provides the latest data and reviews to physicians who need to assess serum omega-6/3 and fatty acids to help diagnose risks and change diets and to inform industry and the scientific community with reviews of research for actions including new studies and therapies.

Breast cancer is the most common cancer in females that accounts for highest cancer specific deaths worldwide. In the last few decades research has proven that breast cancer can be treated if diagnosed at early stages and proper therapeutic strategy is adopted. Omics-based recent approaches have unveiled the molecular mechanism behind the breast tumorigenesis and aid in identification of next-generation molecular markers for early diagnosis, prognosis, and even the effective targeted therapy. Significant development has taken place in the field of omics in breast cancer in the last decade. The most promising omics approaches and their outcomes in breast cancer have been presented in this book for the first time. The book covers omics technologies and budding fields such as breast cancer miRNA, lipidomics, epigenomics, proteomics, nutrigenomics, stem cell, pharmacogenomics and personalized medicine, and many more along with conventional topics such as breast cancer management etc. It is a research-based reference book useful for clinician-scientists, researchers, geneticists and health care industries involved in various aspects of breast cancer. The book will also be useful for students of biomedicine, pathology, and pharmacy.

Omics for Personalized Medicine will give to its prospective readers the insight of both the current developments and the future potential of personalized medicine. The book brings into light how the pharmacogenomics and omics technologies are bringing a revolution in transforming the medicine and the health care sector for the better. Students of biomedical research and medicine along with medical professionals will benefit tremendously from the book by gaining from the diverse fields of knowledge of new age personalized medicine presented in the highly detailed chapters of the book. The book chapters are divided into two sections for convenient reading with the first section covering the general aspects of pharmaocogenomic technology that includes latest research and development in omics technologies. The first section also highlights the role of omics in modern clinical trials and even discusses the ethical consideration in pharmocogenomics. The second section is focusing on the development of personalized medicine in several areas of human health. The topics covered range from metabolic and neurological disorders to non-communicable as well as infectious diseases, and even explores the role of pharmacogenomics in cell therapy and transplantation technology. Thirty-four chapters of the book cover several aspects of pharmacogenomics and personalized medicine and have taken into consideration the varied interest of the readers from different fields of biomedical research and medicine. Advent of pharmacogenomics is the future of modern medicine, which has resulted from culmination of decades of research and now is showing the way forward. The book is an honest endeavour of researchers from all over the world to disseminate the latest knowledge and knowhow in personalized medicine to the community health researchers in particular and the educated public in general.

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