TM4SF1 Antibody (PA5-21119)

Performance guaranteed

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the performance of our antibodies with the InvitrogenTM
antibody performance guarantee. If an InvitrogenTM antibody
doesn't perform in your experiment as described on our website
or datasheet, we'll replace the product at no cost to you, or
if you prefer, we'll provide you with a credit for a future
purchase.*
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Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C

Tested Applications

Dilution *

Immunocytochemistry (ICC)

20 ug/ml

Immunofluorescence (IF)

20 µg/ml

Immunohistochemistry (IHC)

5 µg/ml

Western Blot (WB)

0.5-1 ug/ml

* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the
product for use in their own experiment using appropriate negative and positive controls.

Product Specific Information

A suggested positive control is human lung tissue lysate.

PA5-21119 can be used with blocking peptide PEP-1233.

Background/Target Information

TM4SF1 is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains and mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. TM4SF1 is a cell surface antigen and is highly expressed in the vascular endothelium of several human cancers. Knockdown experiments of TM4SF1 prevented filopodia formation, inhibited cell mobility, blocked cytokinesis, and inhibited maturation of VEGF-A-induced angiogenesis, suggesting that TM4SF1 may be an attractive target for anti-angiogenesis therapy.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.