This blog chronicles the research of the UsefulChem project in the Bradley lab at Drexel University. The main project currently involves the synthesis of novel anti-malarial compounds. The work is done under Open Notebook Science conditions with the actual detailed lab notebook located at usefulchem.wikispaces.com. More general comments posted here relate to Open Science, especially when associated with chemistry.

First, and foremost, this demonstrates that lab notebook pages and blog posts can be used to support claims made in a peer reviewed article. In a way this isn't drastically new since it has been possible for a while now to cite web pages in the peer reviewed literature. The key question is whether the reference is appropriate, regardless of its format. When providing a reference for a melting point or spectrum, nothing is more relevant that the lab notebook page where the specific batch of product was obtained and characterized.

Third, this is a good example of the use of video to enhance the communication of a protocol for a chemical reaction. But this is not a shortcut by any means. The process of writing a script and preparing for the shoot was very time-consuming because we were describing a whole workflow. When using video as raw data to record details of a specific experiment, it can actually save time that would otherwise be required to describe using text.

Finally, JoVE is an example of an Open Access journal with some Web2.0 capabilities, like the ability to leave comments and label them as agreeing or disagreeing with the authors. The final article can now also serve as a location for continuing the scientific conversation.

4 Comments:

This whole process is inspiring. Congratulations on this achievement! I'm still skeptical of OPN working for biologists and/or those in the biomedical sciences where the competition for data can be intense. But if you don't try something, you'll never know!