The mice were treated with injections of bone morphogenetic protein-7 (BMP-7), a treatment Hruska found in previous research could prevent bone weakening in mice whose kidneys had been damaged or removed.

Paul Krebsbach, DDS and colleagues from the University of Michigan School of Dentistry in Ann Arbor used an adenovirus vector engineered to express bone morphogenetic protein-7 (BMP-7) to transduce human gingival or rat dermal fibroblasts.

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