'A new review of the potential for this therapy has been favourable showing there is a potential role for stimulation of the genioglossus muscle, but it is still early days, and we need to wait for the result of further trials to see just how effective this treatment may be, 'says Professor Jim Horne, head of the sleep laboratory at Loughborough University.

This development change is consistent with the observation in adult rat that mAChR activation suppresses inspiratory-related activity of the genioglossus muscle The high - (CX614) and low-impact (CX717) AMPAKINES both alleviated the DAMGO-induced depression of XII MN activity and inspiratory synaptic drive in a dose-dependent manner.

The Apnex HGNS System is intended to work by restoring neuromuscular activity to the genioglossus muscle by stimulating the hypoglossal nerve synchronous with inspiration to mitigate upper airway collapse during sleep.