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Form 8.3 - TAKEDA PHARMACEUTICAL CO LTD - AMENDMENT

BUS

Form 8.3 - TAKEDA PHARMACEUTICAL CO LTD - AMENDMENT

BARCLAYS PLC

FORM 8.3

Amendment to Purchases & Sales

PUBLIC OPENING POSITION DISCLOSURE/DEALING DISCLOSURE BY

A PERSON WITH INTERESTS IN RELEVANT SECURITIES REPRESENTING 1% OR MORE

Rule 8.3 of the Takeover Code (the Code)

1. KEY INFORMATION

(a)

Full name of discloser:

Barclays PLC.

(b)

Owner or controller of interest and short

positions disclosed, if different from 1(a):

(c)

Name of offeror/offeree in relation to whose

TAKEDA PHARMACEUTICAL CO LTD

relevant securities this form relates:

(d)

If an exempt fund manager connected with an

offeror/offeree, state this and specify identity of

offeror/offeree:

(e)

Date position held/dealing undertaken:

12 December 2018

(f)

In addition to the company in 1(c) above, is the discloser making

YES:

disclosures in respect of any other party to the offer?

SHIRE PLC

2. POSITIONS OF THE PERSON MAKING THE DISCLOSURE

If there are positions or rights to subscribe to disclose in more
than one class of relevant securities of the offeror or offeree named in
1(c), copy table 2(a) or (b) (as appropriate) for each additional class
of relevant security.

(a) Interests and short positions in the relevant securities of the
offeror or offeree to which the disclosure relates following the dealing
(if any)

Class of relevant security:

Ordinary NPV

Interests

Short Positions

Number

(%)

Number

(%)

(1)

Relevant securities owned

and/or controlled:

12,151,001

1.53%

14,139,354

1.78%

(2)

Cash-settled derivatives:

13,911,990

1.75%

11,146,635

1.40%

(3)

Stock-settled derivatives (including options)

and agreements to purchase/sell:

10,671,600

1.34%

11,091,600

1.40%

TOTAL:

36,734,591

4.62%

36,377,589

4.58%

All interests and all short positions should be disclosed.

Details of any open stock-settled derivative positions (including
traded options), or agreements to purchase or sell relevant securities,
should be given on a Supplemental Form 8 (Open Positions).

(b) Rights to subscribe for new securities (including directors and
other employee options)

Class of relevant security in relation to which subscription right
exists:

Details, including nature of the rights concerned and relevant
percentages:

3. DEALINGS (IF ANY) BY THE PERSON MAKING THE DISCLOSURE

Where there have been dealings in more than one class of relevant
securities of the offeror or offeree named in 1(c), copy table 3(a),
(b), (c) or (d) (as appropriate) for each additional class of relevant
security dealt in.

The currency of all prices and other monetary amounts should be
stated.

(a) Purchases and sales

Class of relevant

Purchase/sale

Number of

Price per unit

security

securities

ADR

Purchase

34,931

16.6240 USD

ADR

Sale

11,135

16.7011 USD

ADR

Sale

23,796

16.5880 USD

Ordinary NPV

Purchase

300

3,734.3333 JPY

Ordinary NPV

Purchase

300

3,741.5000 JPY

Ordinary NPV

Purchase

600

3,734.1666 JPY

Ordinary NPV

Purchase

700

3,746.5714 JPY

Ordinary NPV

Purchase

735

3,742.5142 JPY

Ordinary NPV

Purchase

892

3,729.2601 JPY

Ordinary NPV

Purchase

1,000

3,727.5000 JPY

Ordinary NPV

Purchase

1,100

3,728.6363 JPY

Ordinary NPV

Purchase

2,220

3,739.0581 JPY

Ordinary NPV

Purchase

2,800

3,732.2142 JPY

Ordinary NPV

Purchase

3,475

3,737.5974 JPY

Ordinary NPV

Purchase

4,000

3,730.2375 JPY

Ordinary NPV

Purchase

4,260

3,741.7826 JPY

Ordinary NPV

Purchase

4,900

3,728.9163 JPY

Ordinary NPV

Purchase

5,600

3,729.7446 JPY

Ordinary NPV

Purchase

6,300

3,709.3650 JPY

Ordinary NPV

Purchase

6,500

3,734.6538 JPY

Ordinary NPV

Purchase

7,847

3,733.9598 JPY

Ordinary NPV

Purchase

9,100

3,673.0000 JPY

Ordinary NPV

Purchase

9,933

3,729.5579 JPY

Ordinary NPV

Purchase

10,200

3,736.9656 JPY

Ordinary NPV

Purchase

12,966

3,744.0000 JPY

Ordinary NPV

Purchase

14,400

3,728.7638 JPY

Ordinary NPV

Purchase

14,900

3,666.7315 JPY

Ordinary NPV

Purchase

17,200

3,716.6279 JPY

Ordinary NPV

Purchase

18,500

3,729.6524 JPY

Ordinary NPV

Purchase

19,838

3,732.3176 JPY

Ordinary NPV

Purchase

22,100

3,733.6606 JPY

Ordinary NPV

Purchase

23,000

3,718.0217 JPY

Ordinary NPV

Purchase

30,300

3,736.1402 JPY

Ordinary NPV

Purchase

46,800

3,718.0000 JPY

Ordinary NPV

Purchase

74,800

3,725.5882 JPY

Ordinary NPV

Purchase

123,100

3,711.3021 JPY

Ordinary NPV

Purchase

283,700

3,713.5364 JPY

Ordinary NPV

Purchase

650,500

3,717.0387 JPY

Ordinary NPV

Purchase

682,000

3,716.5464 JPY

Ordinary NPV

Sale

31

3,685.6452 JPY

Ordinary NPV

Sale

31

3,689.6451 JPY

Ordinary NPV

Sale

166

3,685.0481 JPY

Ordinary NPV

Sale

289

3,673.9180 JPY

Ordinary NPV

Sale

304

3,689.5921 JPY

Ordinary NPV

Sale

385

3,689.1740 JPY

Ordinary NPV

Sale

600

3,734.1666 JPY

Ordinary NPV

Sale

952

3,691.4936 JPY

Ordinary NPV

Sale

1,000

3,727.5000 JPY

Ordinary NPV

Sale

1,040

3,682.7798 JPY

Ordinary NPV

Sale

1,102

3,694.0608 JPY

Ordinary NPV

Sale

1,400

3,718.3571 JPY

Ordinary NPV

Sale

1,679

3,690.4604 JPY

Ordinary NPV

Sale

2,000

3,672.6000 JPY

Ordinary NPV

Sale

2,800

3,673.0000 JPY

Ordinary NPV

Sale

3,021

3,682.6521 JPY

Ordinary NPV

Sale

4,000

3,730.2375 JPY

Ordinary NPV

Sale

4,200

3,710.1428 JPY

Ordinary NPV

Sale

4,600

3,733.5434 JPY

Ordinary NPV

Sale

4,900

3,728.9163 JPY

Ordinary NPV

Sale

5,600

3,729.7446 JPY

Ordinary NPV

Sale

6,500

3,734.6538 JPY

Ordinary NPV

Sale

6,600

3,707.2272 JPY

Ordinary NPV

Sale

6,900

3,719.9710 JPY

Ordinary NPV

Sale

7,900

3,700.0000 JPY

Ordinary NPV

Sale

10,200

3,736.9656 JPY

Ordinary NPV

Sale

14,300

3,728.6678 JPY

Ordinary NPV

Sale

18,500

3,729.6524 JPY

Ordinary NPV

Sale

30,100

3,717.7940 JPY

Ordinary NPV

Sale

30,100

3,709.5647 JPY

Ordinary NPV

Sale

30,600

3,736.1928 JPY

Ordinary NPV

Sale

40,500

3,728.5061 JPY

Ordinary NPV

Sale

55,300

3,718.0000 JPY

Ordinary NPV

Sale

123,100

3,710.8091 JPY

Ordinary NPV

Sale

452,100

3,715.1767 JPY

Ordinary NPV

Sale

665,400

3,715.9122 JPY

Ordinary NPV

Sale

674,100

3,716.7403 JPY

(b) Cash-settled derivative transactions

Class of

Product

Nature of dealing

Number of

Price per

relevant

description

reference

unit

security

securities

Ordinary NPV

SWAP

Long

31

3,685.6314 JPY

Ordinary NPV

SWAP

Long

31

3,689.6310 JPY

Ordinary NPV

SWAP

Long

166

3,685.0491 JPY

Ordinary NPV

SWAP

Long

289

3,673.9180 JPY

Ordinary NPV

SWAP

Long

304

3,689.5920 JPY

Ordinary NPV

SWAP

Long

385

3,689.1739 JPY

Ordinary NPV

SWAP

Long

952

3,691.4933 JPY

Ordinary NPV

CFD

Long

1,000

3,744.7760 JPY

Ordinary NPV

SWAP

Long

1,040

3,682.7807 JPY

Ordinary NPV

SWAP

Long

1,102

3,694.0615 JPY

Ordinary NPV

SWAP

Long

1,600

3,718.0000 JPY

Ordinary NPV

SWAP

Long

1,679

3,690.4599 JPY

Ordinary NPV

SWAP

Long

3,021

3,682.6523 JPY

Ordinary NPV

SWAP

Long

5,400

3,721.9807 JPY

Ordinary NPV

CFD

Long

6,000

3,672.6328 JPY

Ordinary NPV

CFD

Long

180,000

3,712.6072 JPY

Ordinary NPV

SWAP

Short

100

3,709.0000 JPY

Ordinary NPV

SWAP

Short

400

3,728.6250 JPY

Ordinary NPV

SWAP

Short

735

3,742.5140 JPY

Ordinary NPV

SWAP

Short

892

3,729.2608 JPY

Ordinary NPV

SWAP

Short

2,220

3,739.0587 JPY

Ordinary NPV

SWAP

Short

3,475

3,737.5978 JPY

Ordinary NPV

SWAP

Short

4,260

3,741.7830 JPY

Ordinary NPV

SWAP

Short

4,900

3,669.1651 JPY

Ordinary NPV

SWAP

Short

7,847

3,733.9599 JPY

Ordinary NPV

SWAP

Short

9,933

3,729.5579 JPY

Ordinary NPV

SWAP

Short

19,838

3,732.3176 JPY

Ordinary NPV

CFD

Short

45,000

3,718.0000 JPY

(c) Stock-settled derivative transactions (including options)

(i) Writing, selling, purchasing or varying

Class of relevant security

Product description e.g. call option

Writing, purchasing, selling, varying etc.

Number of securities to which option relates

Exercise price per unit

Type

e.g. American, European etc.

Expiry date

Option money paid/ received per unit

(ii) Exercise

Class of relevant security

Product description

e.g. call option

Exercising/ exercised against

Number of securities

Exercise price per unit

(d) Other dealings (including subscribing for new securities)

Class of relevant security

Nature of dealing

e.g. subscription, conversion

Details

Price per unit (if applicable)

4. OTHER INFORMATION

(a) Indemnity and other dealing arrangements

Details of any indemnity or option arrangement, or any agreement or
understanding, formal or informal, relating to relevant securities
which may be an inducement to deal or refrain from dealing entered
into by the person making the disclosure and any party to the offer
or any person acting in concert with a party to the offer:

Irrevocable commitments and letters of intent should not be
included. If there are no such agreements, arrangements or
understandings, state none

None

(b) Agreements, arrangements or understandings relating to options or
derivatives

Details of any agreement, arrangement or understanding, formal or
informal, between the person making the disclosure and any other
person relating to:

(i) the voting rights of any relevant securities under any option;
or

(ii) the voting rights or future acquisition or disposal of any
relevant securities to which any derivative is referenced:

If there are no such agreements, arrangements or
understandings, state none

None

(c) Attachments

Is a Supplemental Form 8 (Open Positions) attached?

YES

Date of disclosure:

14 Dec 2018

Contact name:

Large Holdings Regulatory Operations

Telephone number:

020 3134 7213

Public disclosures under Rule 8 of the Code must be made to a
Regulatory Information Service.

The Panels Market Surveillance Unit is available for consultation in
relation to the Codes disclosure requirements on +44 (0)20 7638 0129.