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Abstract

A novel tomographic method based on the laser speckle contrast, speckle contrast optical tomography (SCOT) is introduced that allows us to reconstruct three dimensional distribution of blood flow in deep tissues. This method is analogous to the diffuse optical tomography (DOT) but for deep tissue blood flow. We develop a reconstruction algorithm based on first Born approximation to generate three dimensional distribution of flow using the experimental data obtained from tissue simulating phantoms.

The three dimensional slice plot of the reconstructed flow velocity for original velocity of 3.18 cm/s, 1.06 cm/s and 0.43 cm/s are shown in (a), (b) and (c) respectively. The volume integral of the reconstructed velocity against the original velocity is shown in (d) where the volume integration is done in a predetermined volume.