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hi are you sure the CRP is exactly 0.3 mg/L? any chance the units are slightly different? because this uses 3 mg/l as its cutoff

Dietary magnesium intake is inversely associated with serum C-reactive protein levels: meta-analysis and systematic reviewhttp://www.nature.com/ejcn/journal/v68/ ... 0147a.htmlA data set derived from seven cross-sectional studies including 32 918 participants was quantitatively assessed. A weighted inverse association between Mg intake and serum CRP levels was observed (β-coefficient: −0.0028; 95% confidence interval (CI), −0.0043 to −0.0013; Ptrend=0.001) from four cross-sectional studies. The pooled OR (95% CI) of having CRP greater than or equal to 3 mg/l was 1.49 (1.18–1.89) on comparing the lowest to the highest group of Mg intake from three studies with the data available. Qualitative assessment among five intervention studies also showed a potential beneficial effect of Mg intake on serum CRP levels.

This meta-analysis and systematic review indicates that dietary Mg intake is significantly and inversely associated with serum CRP levels. The potential beneficial effect of Mg intake on chronic diseases may be, at least in part, explained by inhibiting inflammation.

re LDL. last time i helped someone deal with elevated cholesterol issues specifically, it was personal real life stuff and ended up being was the impetus for going vegan in the 90s. worked short term. big mistake long term. maybe more bran and exercise???

glad you are feeling better. fwiw it's worth i don't take paracetamol or other similar pain killers - only extra one or two magnesium glycinate powder caps if it comes right down to it.

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Yes I am sure it is 0.3 mg/L. Normal range is 0 to 5 mg/L. I suspect my first Rebif side effect today, the day after flu like symptoms.

I do plenty walking. Maybe little bit high mono saturated fats so I will decrease my fat intake. I had lots of cortisol treatment in the last month. The bad result may be related with it. 1 month later I will have all cholesterol related tests.

Update Liver Tests:

The only test I had before was ALT 60 U/L. 3 weeks of %20 dose.

New test is after 1 weeks of %20 and 2 weeks of %50 dose.

ALT increased to 64 U/L (I expected much more increase)AST is 24 U/LGGT is 50 U/L

ok i misread what you had said on the last page. i thought your doc had said it was high, not that it should be *higher*. i am used to hearing about elevated CRP not depressed levels!

brushing up:C-Reactive Protein, Inflammation, and Cardiovascular DiseaseClinical Updatehttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1336715/"For high sensitivity assays of CRP or “hsCRP,” we say that less than 1 mg/L is low risk, 1 to 3 mg/L is moderate risk, and greater than 3 mg/L is high risk—that's simple enough. But the continuum extends beyond that. The patients with the very highest levels of hsCRP —5 to 10, 10 to 20, or even greater than 20 mg/L"

not sure what this contributes exactly, but here it is fwiw:

Very low C-reactive protein in apparently healthy individuals: physiological status or just a reflection of an improved health profile.https://www.ncbi.nlm.nih.gov/pubmed/17852082"The arbitrary cut-off point of hs-CRP (<or=0.16 mg l(-1)) was determined at the lower detection level of the assay. A total of 6588 apparently healthy individuals were screened following exclusion of recent infection/inflammation by using a detailed questionnaire. One hundred and sixty (2.4%) individuals out of the above-mentioned cohort presented hs-CRP concentrations of <or=0.16 mg l(-1). They were found to be significantly younger and lean, had an improved lipid profile and an attenuated acute-phase response in terms of lower erythrocyte sedimentation rate and fibrinogen concentration as well as white blood cell count. In addition, these individuals had less atherothrombotic risk factors..."

just looking around for causes of / issues with low CRP, nothing specific coming up so far.https://labtestsonline.org/understandin ... /test#what"If the CRP level is initially elevated and drops, it means that the inflammation or infection is subsiding and/or responding to treatment."

i have no idea how cortisol might affect LDL (or not). hopefully next month things are all sorted out

So lymphopenia and first flu-like side effect today. I will visit my neurologist tomorrow and find an MS specialized dietitian soon. I see monitoring is extremely important after CIS. I will continue monthly tests for everything.

Zyklon wrote:Yes I am sure it is 0.3 mg/L. Normal range is 0 to 5 mg/L. I suspect my first Rebif side effect today, the day after flu like symptoms.

I do plenty walking. Maybe little bit high mono saturated fats so I will decrease my fat intake. I had lots of cortisol treatment in the last month. The bad result may be related with it. 1 month later I will have all cholesterol related tests.

Update Liver Tests:

The only test I had before was ALT 60 U/L. 3 weeks of %20 dose.

New test is after 1 weeks of %20 and 2 weeks of %50 dose.

ALT increased to 64 U/L (I expected much more increase)AST is 24 U/LGGT is 50 U/L

I guess 1 liter of water after injection in two hours works for me.

I did Avonex for 10 years. I found that ibuprofen was indispensable for counter acting the side effects. Try taking 200 mg of ibuprofen at the time of your shot and then another 200 mg about 4 hours later.

now that your b12 levels are up for sure sounds like an idea to taper. daily maintenance requirements are far lower than amounts used in a typical therapeutic megadose regimen.

same for d3. 'long term' d3 megadose studies (usually no more than 3-6 months) are not tracking all potential side effects over long enough time periods. patients are in this for life. consider dialing it back and monitoring serum levels. i would suggest keeping it in the 40 ng/ml ballpark, at least/especially until you have other factors sorted out.

i wonder if improving phosphorus status would have helped boost serum d3 levels, without megadosing d3 as occurs with increased magnesium levels.

speaking of which once again, nothing in that study about magnesium. would be nice if i could find an explanation for this seeming blind spot in the research, rather than just noting the gap most of the time ... glad i have been able to find some studies that do examine this d3/mag relationship..

In the book I recommended earlier, Could It Be B12? An Epidemic of Misdiagnoses by Sally M. Pacholok, RN, BSN, and Jeffrey J. Stuart, D.O., the authors state on page 11: “For brain and nervous system health and prevention of disease in older adults, serum B12 levels should be maintained near or above 1000 pg/mL.” http://b12awareness.org/could-it-be-b12 ... diagnoses/

Some B12 experts consider the optimal range to be 1100-1300 pg/mL

In view of these experts' opinions, 540 pg/mL is not at all excessive. In my opinion (I have no medical background), it is not necessary to decrease your supplement (but this should be discussed with your doctor).

As for vitamin D, your level of 38.1 ng/mL is approaching the minimum recommendation of GrassrootsHealth (40-60 ng/mL). Some vitamin D experts recommend a level between 70-100 ng/mL for patients with neurological symptoms.

re https://www.ncbi.nlm.nih.gov/pubmed/3398357 i had spent some time trying to figure out 1. when and where the 500 lower end came from in 1988, and as referenced in another older letter, also 2. what any more recent updates might have been and the rationale behind them.

can't get into the full text of this and if i could, not sure i'd get anything out of it :S

[A case of subacute combined degeneration with normal serum vitamin B12 level].[Article in Japanese]Nagaishi A1, Takashima H, Fukuda Y, Kuroda Y.Author informationAbstractA 40-year-old woman was admitted to our hospital because of pancytopenia with megaloblastic anemia. Two months later she complained of rapidly progressive gait disturbance and numbness in the distal part of limbs. She also told that her hair had turned totally gray in the third decade. Neurologically, mental state, cranial nerves and cerebellar functions were normal. Superficial sensations were impaired below the lower thoracic level and deep sensations were completely lost in the lower limbs. Moderate weakness was found in the lower limbs, symmetrically. Deep tendon reflexes were diminished in the upper limbs and absent in the lower limbs. Babinski's reflex was positive bilaterally. MR images of the spinal cord showed hyperintensity in the posterior column below the thoracic cord. Although the serum level of vitamin B12 was within normal range, serum homocysteine level was elevated markedly. Under the diagnosis of subacute combined degeneration (SCD) due to possible vitamin B12 deficiency, the treatment with intravenous injections of 500 micrograms/day of mecobalamin was undertaken. Muscle strength and sensory impairment improved progressively and she became able to walk with a cane. The coloration of her gray hair was also noted. After treatment, pancytopenia and megaloblastic anemia also markedly improved. Vitamin B12 became high in serum concentration and the serum level of homocysteine became normal. These clinical and laboratory findings support the diagnosis of SCD with normal serum level of vitamin B12 in our case, suggesting that the level of vitamin B12 in serum does not always correlate with that in tissue and, therefore, SCD should not be excluded just only by the reason of normal serum vitamin B12 level.

please consider normalizing phosphorus, calcium, and other nutrients that may interact with d3 prior to pushing levels higher. i speak from unpleasant prior xp (not with phosphorus however)

while hypercalcemia is an established consequence of excess d3 intake, and a high calcium to magnesium ratio can be expected to be problematic in similar ways to normal calcium with low magnesium, i know less about phosphorus. hence:

As you say cross interactions can be messy. I know it is a balance issue and can be very complex. For now I try to achieve OK levels. MS optimal levels will be tricky and sure it will require professional consultancy.

also interesting. in the absence of other factors, suggests low vit d3 in the etiology of hypophosphatemia. if this is the case for you, i expect that means you should see serum P coming up as serum 25(OH)vitd3 increases. something else going on perhaps..

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