..In this review, we present a model of postinfarct ventricular tachycardia, a method for gene delivery to this area, and results of KCNH2-G628S gene transfer to manipulate cellular refractory properties in the arrhythmia model...

Vascular disrupting agent for neovascular age related macular degeneration: a pilot study of the safety and efficacy of intravenous combretastatin A-4 phosphate

..Fibrosis, cellular dysfunction, and gap junction protein alterations occur in AF and cause conduction delay. We performed this study to test the hypothesis that gap junction protein overexpression would improve conduction and prevent AF...

Ventricular tachycardia from the healed myocardial infarction scar: validation of an animal model and utility of gene therapy

Tetsuo SasanoHeart and Vascular Research Center, Case Western Reserve University School of Medicine, Cleveland, OH 44109, USAHeart Rhythm 6:S91-7. 2009

..In this work, we characterize the animal model and review the gene transfer results...

..A variety of animal models exist, including models of lone atrial fibrillation and models of atrial fibrillation in the setting of heart failure, aging, or pericardial inflammation. This article reviews these various models...

..Historically attributed to blood stasis, little is known about the adverse effects of elevated chamber filling pressure on endocardial function, which could predispose to intracardiac thrombus formation...

..Thus, these results indicate that gene transfer of Gem functions as a genetic calcium channel blocker, the local application of which can effectively modulate cardiac electrical and contractile function...