Red Blarggs and their variants make their first chronological appearance in Super Mario World 2: Yoshi's Island. They resemble blob-like creatures with large mouths, and have frowning black eyes with no pupils. Red Blarggs behave almost the same way as the original Blargg in Super Mario World, dwelling in lava and attempting to leap towards outsiders. Yoshis can defeat them with eggs, but they reappear after a few seconds; however, a POW Block can defeat them permanently. There are two giant versions: Gargantua Blargg, which rises out of the lava and tries to block the path, and Nep-Enut, which act the same but are blue and live in water.

In Yoshi's Island DS, Red Blarggs reappear with the same appearance and behavior, as well as Gargantua Blarggs and Nep-Enuts. The latter have a smaller counterpart called Egg-enuts, which have a similar size to Red Blarggs but employ a different tactic; they hide with a fake Yoshi Egg as a lure. In addition, there is a new type of Gargantua Blargg, which are even larger and can destroy dense rocks.