Juge-Morineau et al analysed the immunoglobulin heavy chain V-region (Ig HV) genes of three IgD, one IgM, and one biclonal (IgG and IgM) multiple myeloma for the presence of somatic mutations based on molecular analysis of the Ig HV.

In rare conditions, electrophoresis produces more than one narrow peak simultaneously, suggesting the existence of more than one clonal antibody and establishing a biclonal, triclonal or oligoclonal gammopathy (3).

For example, the use of high-resolution protein electrophoresis with immunofixation to confirm monoclonal and biclonal paraprotein patterns has had a major impact on the practice of medicine at our hospital.

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