A meta-analysis of clinical trial data showed that people taking 2.4g or more of ibuprofen per day are at a higher risk of arterial thrombotic events, such as heart attack and stroke, than people taking placebo.

note that ibuprofen is contraindicated in patients with severe heart failure

These recommendations also apply to dexibuprofen (a high dose of dexibuprofen is 1.2g or more per day, which is equivalent to 2.4g ibuprofen).

The review also examined the latest data on the possible interaction between ibuprofen and low-dose aspirin, and concluded that occasional ibuprofen use is unlikely to have a clinically meaningful effect on the benefits of low-dose aspirin.