adipsin

Adipsin

A serine protease secreted by adipocytes into the circulation which is deficient in some animal models of obesity. It is identical to complement factor D.

adipsin

An enzyme secreted by fat cells, and also present in the Schwann cells of nerve fibres, that is thought to regulate fat metabolism. It acts on free lipoproteins and is concerned with fat oxidation. Its levels are markedly reduced in genetically obese mice. The full function of adipsin remains unclear.

For adiponectin, adipsin, HGF, leptin, PAI-1, resistin, TIMP-1, and thrombopoietin, the antibody pairs used for ELISA and MIA maybe identical, but the antibody clones were not disclosed by the ELISA manufacturer.

After finding abnormal levels of a substance called adipsin in overweight rodents, researchers in Boston said last week that adipsin may be a contender for the adipostat title, as well as a marker to differentiate among obesities due to defects in genes, metabolism or just plain will power.

Reported in the July 24 SCIENCE, experimentsby scientists at Beth Israel Hospital and Harvard Medical School showed that adipsin is primarily found in adipose tissue (fat), is carried in the bloodstream and is produced in abnormal levels in certain types of obesity.

MS-based peptide fingerprinting identified many of these proteins as previously described adipokines with typical secretory signal peptides such as adiponectin, adipsin, complement factor 3, and others (data not shown).

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