4Department Of Soft Tissue Tumors, Rostov Research Institute of Oncology, Rostov on Don/RU

5Department Of Chemotherapy, Rostov Research Institute of Oncology, 344037 - Rostov on Don/RU

Abstract

Background

The purpose of the study was to analyze prognostic value of some cellular factors of immunologic microenvironment in soft tissue sarcomas (STS) for the development of an effective response to treatment for primary and recurrent tumors.

Results

Patients were divided into 4 groups according to the results of clinical observation: group A – primary tumors, marked treatment effect; group B – primary tumors, no treatment effect; group C – recurrent tumors, marked treatment effect; and group D - recurrent tumors, no treatment effect. Retrospective assessment of local immunity statuses of patients revealed a number of differences in lymphocyte content. Patients with primary STS showed significant prognostic value of CD16/56+ level in tumor tissue: 12.2 ± 1.6% in marked treatment effect and 6.1 ± 1.2% without an effect (p

Conclusions

A high local level of DN-lymphocytes, especially in recurrent tumors, and decreased content of NK-cells in primary tumors can be considered as prognostic factors for effectiveness of treatment for soft tissue sarcomas.