The station was built in 1855 by Alexis Cendrier for the CF du PLM. The building was built in classical style and is composed of a double rooftop and a large passenger building.

The station lost its view of the city when the transport interchange and dual-carriageway were built in the 1970s. Although much modern building has somewhat tarnished the look of the area, the station retains much of its original features:

The station front features the names of towns served by trains departing Lyon-Perrache.

The platforms are covered by two twin iron rooftops.

It is the terminus of the LGV Sud-Est line, the high-speed railway line from Paris. It is also served by conventional trains from other parts of France, and is the terminus of Line A of the Lyon Metro. It is also the terminus of one of the Lyon tram lines.

The station was built in 1855 by Alexis Cendrier for the CF du PLM. The building was built in classical style and is composed of a double rooftop and a large passenger building.

The station lost its view of the city when the transport interchange and dual-carriageway were built in the 1970s. Although much modern building has somewhat tarnished the look of the area, the station retains much of its original features:

The station front features the names of towns served by trains departing Lyon-Perrache.

The platforms are covered by two twin iron rooftops.

It is the terminus of the LGV Sud-Est line, the high-speed railway line from Paris. It is also served by conventional trains from other parts of France, and is the terminus of Line A of the Lyon Metro. It is also the terminus of one of the Lyon tram lines.

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