The finding of authochtonous cases of schistosomiasis mansoni at Paracatu, Northwest of Minas Gerais State (Brazil) was reported. They were children of ages ranging from 12 to 14, who had never been out of this town. A total of 11,471 Biomphalaria straminea were collected, and all of them were negative to Schistosoma mansoni cercárias and/or sporocystes. The local authorities were advised on, measures to be taken with a view to schistosomiasis control.