Research in our department encompasses all levels of genetic analysis on oncogenesis, including studies aimed at understanding the molecular and genetic mechanisms of oncogenesis. A primary focus is on the structure and function study of Double minutes chromsome (DMs). Otherwise, as one of the three major national centers participating in the Chinese Human Genome Project (CHGP), we were committed to preserving the genetic resource of Chinese minority populations with the goal of exploring their genetic diversity and investigating the association of genetic variants in human diseases.

My research is focused on DMs genes function and applyling in clinical diagnosis, therapy and pronogsis.
DMs is a major phenotype of genome rearrangment during oncogenesis, whereas the function remain unkonwn. We had analysed the sequence of DMs genomes from two kinds of tumor cells, ovarian cancer and colorectal cancer, 27 tumor candidate genes accquired. We have two research projects, to evaluate whether these genes can be used as clinical biomarker and to investigate their precise regulation mechanisms in tumor cells.

Bai Jing, Professor of Genetics, is an associate director of Laboratory of Medical Genetics. She is a member of Genetics Society of China, a member of a council of Chinese Association for Improving Birth Outcome and Child Development, the secretary-general of Genetic Institute of Heilongjiang Province, the associate director of "International Journal of Genetics". Her research interest focuses on protomics analysis for DMs and metastasis in cancer.

Our research interests focus on the collection and preservation of human genetic resource, including blood samples of healthy individuals in different ethnic groups and patients with different diseases. Also, we are interested in analyzing the candidate SNPs (single nucleotide polymorphism) of a certain disease, such as AIDs.

Professor Qiao Yuandong received his MD. and PhD. degrees from Harbin Medical University and finished his Postdoctral training in 2010. He is experts in population genetics, DNA damage-repair gene and HIV-1 infection. His group was focus on human genetic diversity and the association analysis of genetic variants with common diseases. Now, they have collected matched case and control samples and carried out the study to investigate the association of genetic variants in HIV-1 infection, especially interest in DNA damage-repair gene with AIDS.

Zhang Chun-yu received her MD. and PhD. degrees from the Harbin Medical University and finished her Postdoc training in Sun Yat-sen University/Hong Kong University. She has strong expertise in population genetics, gene function, tumor microenvironment and cancer stem cell. As a genetics professor, she has been committed to the genomic changes of tumor cells, especially in the study of extrachromosomal genetic units-double minutes (DMs). Now we current research interest focuses on the formation mechanism of DMs induced by oncogene and the functions of the new genes carried by DMs that involve changes of DNA damage-repair system, the activation of oncogenes and the participation of various signaling pathways in tumor cells.

Our research interests focus on the origin and formation mechanism of Double Minutes (DMs) in cancer cells. In our research, drug-resistant cancer cell lines were used to observe the DMs evolution, and the DNA repair mechanism (such as NHEJ and HR), the function of DMs-containing genes and fusion genes, the DMs structure were analyzed in the process of DMs formation.

We focus on elucidating the molecular mechanisms of the growth, differentiation and metastasis of solid tumor, including the signaling pathways that positively and negatively regulate activation of tumor related genes, as well as identifying and evaluating potential target genes for therapeutic intervention. We are also committed to investigating the ultrastructure and function of Double minute chromosomes (DMs) in oncogenesis.