It does mean that sin affects each and every aspect of a person: the mind, body, will, and spirit.

It does mean that acts thought to be altruistic will always contain at least a shade of improper motive - nothing one does is born totally and completely out of a perfect, flawless desire to serve God.

It does mean that we as human beings are wholly incapable of eradicating our problem of sin by means of our own volition.