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The purpose of this study is to compare the the Nexgen knee replacement system using cementless fixation with the same system using cemented fixation. At minimum 2-year follow-up, the hypothesis is that NexGen total knee arthroplasties using cementless and cemented fixation will demonstrate no differences in clinical outcome based on Oxford and Knee Society scores, patient-assessed visual analog pain, clinical complications, radiographic fixation and implant survivorship.

Radiographic analysis will include evaluation of component and limb alignment, evidence of component subsidence or migration, and the presence and progression of radiolucent lines between the prosthesis, bone and cement.

Radiographic analysis [ Time Frame: 1 year ]

Radiographic analysis will include evaluation of component and limb alignment, evidence of component subsidence or migration, and the presence and progression of radiolucent lines between the prosthesis, bone and cement.

Radiographic analysis [ Time Frame: 2 year ]

Radiographic analysis will include evaluation of component and limb alignment, evidence of component subsidence or migration, and the presence and progression of radiolucent lines between the prosthesis, bone and cement.

Radiographic analysis [ Time Frame: 5 year ]

Radiographic analysis will include evaluation of component and limb alignment, evidence of component subsidence or migration, and the presence and progression of radiolucent lines between the prosthesis, bone and cement.

Radiographic analysis [ Time Frame: 10 year ]

Radiographic analysis will include evaluation of component and limb alignment, evidence of component subsidence or migration, and the presence and progression of radiolucent lines between the prosthesis, bone and cement.

Radiographic analysis [ Time Frame: 15 year ]

Radiographic analysis will include evaluation of component and limb alignment, evidence of component subsidence or migration, and the presence and progression of radiolucent lines between the prosthesis, bone and cement.

Complications [ Time Frame: Date of surgery ]

The number and type of adverse events will be monitored to assess safety.

Complications [ Time Frame: 4 week ]

The number and type of adverse events will be monitored to assess safety.

Complications [ Time Frame: 4 month ]

The number and type of adverse events will be monitored to assess safety.

Complications [ Time Frame: 1 year ]

The number and type of adverse events will be monitored to assess safety.

Complications [ Time Frame: 2 year ]

The number and type of adverse events will be monitored to assess safety.

Complications [ Time Frame: 5 year ]

The number and type of adverse events will be monitored to assess safety.

Complications [ Time Frame: 10 year ]

The number and type of adverse events will be monitored to assess safety.

Complications [ Time Frame: 15 year ]

The number and type of adverse events will be monitored to assess safety.

Radiographic analysis [ Time Frame: 4 month ]

Radiographic analysis will include evaluation of component and limb alignment, evidence of component subsidence or migration, and the presence and progression of radiolucent lines between the prosthesis, bone and cement.

Secondary Outcome Measures :

Knee Society Score [ Time Frame: 4 week ]

A standard clinical evaluation system for reporting results for patients undergoing total knee replacement.

Knee Society Score [ Time Frame: 1 year ]

A standard clinical evaluation system for reporting results for patients undergoing total knee replacement.

Knee Society Score [ Time Frame: 2 year ]

A standard clinical evaluation system for reporting results for patients undergoing total knee replacement.

Knee Society Score [ Time Frame: 5 year ]

A standard clinical evaluation system for reporting results for patients undergoing total knee replacement.

Knee Society Score [ Time Frame: 10 year ]

A standard clinical evaluation system for reporting results for patients undergoing total knee replacement.

Knee Society Score [ Time Frame: 15 year ]

A standard clinical evaluation system for reporting results for patients undergoing total knee replacement.

Oxford Knee Score [ Time Frame: 4 week ]

A patient reported questionnaire for assessing the outcome of knee surgery.

Oxford Knee Score [ Time Frame: 1 year ]

A patient reported questionnaire for assessing the outcome of knee surgery.

Oxford Knee Score [ Time Frame: 2 year ]

A patient reported questionnaire for assessing the outcome of knee surgery.

Oxford Knee Score [ Time Frame: 5 year ]

A patient reported questionnaire for assessing the outcome of knee surgery.

Oxford Knee Score [ Time Frame: 10 year ]

A patient reported questionnaire for assessing the outcome of knee surgery.

Oxford Knee Score [ Time Frame: 15 year ]

A patient reported questionnaire for assessing the outcome of knee surgery.

Visual analog pain score [ Time Frame: 4 week ]

Pain score will be measured from a patient-assessed visual analog pain scale.

Visual analog pain score [ Time Frame: 4 month ]

Pain score will be measured from a patient-assessed visual analog pain scale.

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.