..have now shown that the segmentation clock is more complex than previously thought and includes oscillating expression of genes from at least three signaling pathways organized in coordinated networks...

A novel possible mechanism for the genesis of genomic duplications and its experimental test

..The Cre/lox and FLP/FRT systems are the most popular of these. I will discuss how these recombination systems are used in the mouse with special focus on their use to achieve specific gene activation...

Tbx1 is required for proper neural crest migration and to stabilize spatial patterns during middle and inner ear development

..Furthermore, we demonstrate that Hoxa2 regulation of Six2 is confined to a 0.9 kb fragment of the Six2 promoter and that Hoxa2 binds to this promoter region. These results strongly suggest that Six2 is a direct target of Hoxa2...

Evidence for a myotomal Hox/Myf cascade governing nonautonomous control of rib specification within global vertebral domains

..These results suggest that a polymorphism in the Hox/Pax-responsive enhancer may have played a role in the evolution of the vertebrate spine by differently modulating its response to rib-suppressing and rib-promoting Hox proteins. ..