Fan rotating model

I need your helps and suggestions on developing transient rotating Fan which is in the room. I need to capture the flow behavior of transient rotational effect. Kindly provide me how to to do Domain interfacing and what MFR to be used.

To capture transient behaviour in a rotating machine you need the transient-rotor-stator model.

This is all discussed in detail int he documentation and there are some tutorial examples to help you get started. Have a look in the documentation. There is also a best practices guide for turbomachines which you should look at.