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Four medical students while partying one night, spike the drink of an unknowing loner, the hospital janitor, Kenneth, nicknamed "Freakdog". It turns out Freakdog has epilepsy and while partying an epileptic seizure causes him to fall and hit his head. Complicating things, the alcohol spiked with drugs that one of the medical students had swiped from the hospital meant he lost enough oxygen to his brain after the seizure and fall, to result in deep coma.

The students, not wanting to be involved or else risk their futures for their crime, abandon his body on a road in front of the hospital and drive off as fast as they can, hoping someone will come across his body and help him. When they learn about his condition being fatal, one of the students (Arielle Kebbel), attempts to revive him using an experimental drug. The result has horrible and unintended consequences which leads to out of body experiences which Freakdog inflicts on the students who first poisoned then abandoned him. To exact vengeance, he possesses their bodies and through them kills, framing them for murdering each other, while they desperately try to find a way to stop him.