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Hyperthermia is newly back in the interest of both, clinical and research oncologists, because of its properties to directly produce permanent damages of the treated tumors and to elicit important immunological responses against cancer cells by changing their immunogenicity. Microwave ablation is used in the treatment of primary and secondary tumors of the liver. Microwave antennas suitable for hyperthermia needs to be properly designed in order to deliver electromagnetic energy into the tumor tissue with minimal irradiation of healthy tissue Interstitial antennas are used to elevate the temperature of cancer tissues located deep inside of patient’s body. A microwave generator produces microwaves, typically around 2.45 GHz, with 60 W power. Under anesthesia, thin needle electrodes are inserted into the body, usually under ultrasound guidance. A typical treatment cycle takes 60 s, where full power is applied. This produces a lesion of about 2 cm diameter. Treatment is repeated typically three times a week, until the entire tumor is ablated. To obtain the solution for equations of EM deposition inside biological systems, it is required to choose a calculation method. Because human body models have complex geometry, with region of different characteristics, and for this a numerical method has to be employed.