{"title"=>"Fatness-associated FTO gene variant increases mortality independent of fatness - In cohorts of Danish men", "type"=>"journal", "authors"=>[{"first_name"=>"Esther", "last_name"=>"Zimmermann", "scopus_author_id"=>"7101967729"}, {"first_name"=>"Sofia I.I.", "last_name"=>"Kring", "scopus_author_id"=>"24471630200"}, {"first_name"=>"Tina L.", "last_name"=>"Berentzen", "scopus_author_id"=>"6504196108"}, {"first_name"=>"Claus", "last_name"=>"Holst", "scopus_author_id"=>"7004615633"}, {"first_name"=>"Tune H.", "last_name"=>"Pers", "scopus_author_id"=>"24171795400"}, {"first_name"=>"Torben", "last_name"=>"Hansen", "scopus_author_id"=>"7401667966"}, {"first_name"=>"Oluf", "last_name"=>"Pedersen", "scopus_author_id"=>"35373396900"}, {"first_name"=>"Thorkild I.A.", "last_name"=>"Sørensen", "scopus_author_id"=>"36043939900"}, {"first_name"=>"Tine", "last_name"=>"Jess", "scopus_author_id"=>"26643354600"}], "year"=>2009, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "scopus"=>"2-s2.0-84887212356", "pui"=>"354278520", "doi"=>"10.1371/journal.pone.0004428", "isbn"=>"1932-6203 (Electronic)", "sgr"=>"84887212356", "pmid"=>"19214238"}, "id"=>"ec84485c-3aa1-3565-96b5-a914c6731166", "abstract"=>"BACKGROUND: The A-allele of the single nucleotide polymorphism (SNP), rs9939609, in the FTO gene is associated with increased fatness. We hypothesized that the SNP is associated with morbidity and mortality through the effect on fatness. METHODOLOGY/PRINCIPAL FINDINGS: In a population of 362,200 Danish young men, examined for military service between 1943 and 1977, all obese (BMI>or=31.0 kg/m(2)) and a random 1% sample of the others were identified. In 1992-94, at an average age of 46 years, 752 of the obese and 876 of the others were re-examined, including measurements of weight, fat mass, height, and waist circumference, and DNA sampling. Hospitalization and death occurring during the following median 13.5 years were ascertained by linkage to national registers. Cox regression analyses were performed using a dominant effect model (TT vs. TA or AA). In total 205 men died. Mortality was 42% lower (p = 0.001) with the TT genotype than in A-allele carriers. This phenomenon was observed in both the obese and the randomly sampled cohort when analysed separately. Adjustment for fatness covariates attenuated the association only slightly. Exploratory analyses of cause-specific mortality and morbidity prior to death suggested a general protective effect of the TT genotype, whereas there were only weak associations with disease incidence, except for diseases of the nervous system. CONCLUSION: Independent of fatness, the A-allele of the FTO SNP appears to increase mortality of a magnitude similar to smoking, but without a particular underlying disease pattern barring an increase in the risk of diseases of the nervous system.", "link"=>"http://www.mendeley.com/research/fatnessassociated-fto-gene-variant-increases-mortality-independent-fatness-cohorts-danish-men", "reader_count"=>20, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>4, "Student > Doctoral Student"=>1, "Researcher"=>6, "Student > Ph. D. Student"=>4, "Student > Master"=>2, "Lecturer"=>1, "Lecturer > Senior Lecturer"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>4, "Student > Doctoral Student"=>1, "Researcher"=>6, "Student > Ph. D. Student"=>4, "Student > Master"=>2, "Lecturer"=>1, "Lecturer > Senior Lecturer"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Biochemistry, Genetics and Molecular Biology"=>4, "Nursing and Health Professions"=>1, "Agricultural and Biological Sciences"=>7, "Medicine and Dentistry"=>7}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>7}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>7}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>4}, "Unspecified"=>{"Unspecified"=>1}}, "reader_count_by_country"=>{"United Kingdom"=>2, "Iceland"=>1}, "group_count"=>1}

{"files"=>["https://ndownloader.figshare.com/files/909037"], "description"=>"<p>Cox proportional hazards analysis with age as the underlying time scale and delayed entrance at age at time of blood sampling (S-46). Cause of death information was not available in 21 men who died after December 31, 2006.</p>*<p>p<0.05 for the likelihood ratio test (Likelihood ratio tests were used to estimate whether a model including both BMI S-20, BMI S-46 and FTO rs9939609 fitted the data better than a model including only BMI S-20 and BMI S-46)</p>†<p>p<0.05 for interaction between genotype and the original sampling variable (random vs. obese); the interaction term is included in the model</p>‡<p>The category other/unspecified diseases includes benign neoplasms, diseases of the eye, skin and subcutaneous tissue, congenital malformation of the urinary system and symptoms, signs and abnormal clinical and laboratory findings, not otherwise classified.</p>", "links"=>[], "tags"=>["rs9939609", "tt", "ta", "cause-specific", "morbidity", "danish", "men", "adjusted", "bmi", "s-20"], "article_id"=>579475, "categories"=>["Computational Biology", "Genetics", "Biotechnology"], "users"=>["Esther Zimmermann", "Sofia I. I. Kring", "Tina L. Berentzen", "Claus Holst", "Tune H. Pers", "Torben Hansen", "Oluf Pedersen", "Thorkild I. A. Sørensen", "Tine Jess"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0004428.t004"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_FTO_rs9939609_genotype_TT_vs_TA_and_AA_and_cause_specific_mortality_and_morbidity_in_1_628_Danish_men_adjusted_for_BMI_S_20_and_S_46_/579475", "title"=>"<i>FTO</i> rs9939609 (genotype TT vs. TA and AA) and cause-specific mortality and morbidity in 1,628 Danish men adjusted for BMI S-20 and S-46", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-21 06:56:15"}