SERENITY INTERNATIONAL ACADEMY OF HOMEOPATHIC MEDICAL SCIENCE&RESEARCH [SIAHMSR]
www.serenityglobalhomeo.com
The academy is founded in 2013 with a noble intention of raising homeopathy as an evidence based medicine ,at the same time adhering to the principles of classical homeopathy.
http://www.serenityglobalhomeo.com/academy-research.php

Friday, July 31, 2015

A research study on hypothyroidism and miscarriage.- Dr Sanjana vb

A research study on hypothyroidism and miscarriage.-

-Dr Sanjana vb

[SIAHMSR] - academy &research wing of Serenity global homeopathy.

Hypothyroidism and subclinical hypothyroidism in women interfere with fecundity and cause
miscarriage.The statistics of female infertility is given in the table
below.Based on this data a retrospective study was done by Dr Sanjana from 2007
to 2014 in mothers with history of
hypothyroidism and subclinical hypothyroidism or gestational hypothyroidism.
The study outcome and management protocols evolved is described here.

Literature review

In Table 14-4, the
information available from thirteen studies investigating the risk of a
miscarriage in relation with the presence (versus the absence) of AITD has
been compiled . The overall risk of
having a miscarriage was 3-fold to 5-fold greater in women with AITD (and
apparent euthyroidism). In another review by Stagnaro-Green & Glinoer in
2004, a classification was attempted by examining separately an association
between AITD & miscarriage (in 5 studies), between AITD & recurrent
miscarriage (in 7 studies), and finally between AITD & early pregnancy
loss after ART (in 5 studies) . Overall and with only few exceptions, all
studies documented a statistically significant relationship between thyroid
autoimmunity and an increased risk of pregnancy loss. Finally in 2004,
Prummel & Wiersinga published a meta-analysis of both the case-controlled
and longitudinal studies published since 1990, after the association between
miscarriage and AITD was first described 179. The results of this meta-analysis
amply confirmed that an association exists, with an overall increased
relative risk of a miscarriage of 2.73 in women with AITD. Table 14-4 Miscarriages
in women with positive thyroid antibodies

First author

Year

Country

Number of subjects

Positive thyroid antibodies

Miscarriage rate

P value

Stagnaro-Green

1990

U. S. A.

552

19.6 %

17.0 % vs

8.4 %

= 0.011

unselected population study

Glinoer

1991

Belgium

726

6.2 %

13.3 % vs

3.3 %

< 0.005

unselected population study

Lejeune

1993

Belgium

363

6.3 %

22.0 % vs

5.0 %

< 0.005

unselected population, before
14 wks gestation

Pratt

1993

U. S. A.

42

31.0 %

67.0 % vs

33.0 %

n.a.

recurrent spontaneous
abortions

Singh

1995

U. S. A.

487

22.0 %

32.0 % vs

16.0 %

= 0.002

pregnant with assisted
reproductive techniques

Bussen

1995

Germany

66

17.0 %

36.0 % vs

7.0 %

< 0.03

recurrent spontaneous
abortions

Iijima

1997

Japan

1179

10.6 %

10.4 % vs

5.5 % <

0.05

unselected population study

Esplin

1998

U. S. A.

149

33.0 %

29.0 % vs

37.0 % >

0.05

recurrent pregnancy loss

Kutteh

1999

U. S. A.

900

20.8 %

22.5 % vs

14.5 %

= 0.01

two or more consecutive
abortions

Muller

1999

Netherlands

173

14.0 %

33.0 % vs

19.0 %

= 0.29

pregnant with assisted
reproductive techniques

Bussen

2000

Germany

48

30.6 %

54.2 % vs

8.3 %

= 0.002

failure to conceive after 3
cycles of IVF

Dendrinos

2000

Greece

45

32.5 %

37.0 % vs

13.0 %

< 0.05

recurrent spontaneous
abortions

Bagis

2001

Turkey

876

12.3 %

50.0 % vs

14.1 %

< 0.0001

unselected population study

A retrospective
study conducted by Dr Sanjana vb
BHMS also found out that autoimmune
thyroiditis has definite role in limiting the chances of fertility or causing
abortion. Based on this study result the
etiology of autoimmunity was studied meticulously and the outcome pointed out
that prolonged exposure to stress is one of the major triggers for autoimmunity
in women. Since 2007 she studied the effect of some homeopathic drugs in curing
thyroid problems in women with history of severe stress &emotional outbursts
for a prolonged period of time. The study has thrown some light into the effect
of stress related AITD as a major cause of abortions .Stress triggers hyper
secretion of cortisol hormone in our body and the cascade of events ultimately
lead to excess conversion of T4 to reverse T3 hormone or RT3 production. RT3 is
thought to be the culprit for hypothyroidism in AITD women. Homeopathy has definite treatment protocols
for curing stress, autoimmune thyroiditis and hence abortion or infertility in sub
clinical hypothyroid [SCH] and overtly hypothyroid [OH] women.[ Date of study –
May2007 to June 2014]

a systematic review of untreated gestational hypothyroidism gave substantial evidence
regarding the role of maternal hypothyroidism due to AITD [AUTOIMMUNE THYROIDITIS]
for the psycho-neurological outcome in the progeny

Several
clinical studies have investigated the psychological and intellectual outcome
in the offspring of pregnant women with thyroid insufficiency, both in
conditions of hypothyroidism with an adequate iodine nutritional status and
women with mild-moderate iodine deficiency. Overall, the results show that
there is a significantly increased risk of impairment in neuro-psychological
developmental indices, IQ scores, and school learning abilities in the
offspring of untreated hypothyroid mothers.

Homeopathy has treatment protocols for addressing both
hypothyroidism in women of reproductive age group and children presenting with psychological
imbalance, anxiety, depression, lack of concentration consequent to maternal
gestational hypothyroidism. It is very important that homeopathic management is
effective only in women who are at the initial phases of autoimmune
thyroiditis. Autoimmune attack for a prolonged time period can destroy the gland
and thus limits the chances of recovery.