Poly drug use refers to the use two or more psychoactive drugs in combination to achieve a particular effect. In many cases, this makes the experience far more dangerous than taking the substances alone.

There are many popular drug combinations, including, but not limited to[1]:

While many recreational drug users use multiple drugs to increase intoxication for pleasurable effects, poly drug use can pertain to an increase in spiritual entheogenic properties, for example 2C-I and LSD or morning glory seeds and San Pedro cactus.

Poly drug use often carries with it more risk than use of a single drug, due to an increase in side effects, and unique pharmacological interactions.