This blog is here to amuse you. There are funny stories, pictures, jokes and news. The content is updated every day. Anyone with a sense of humor should get at least one laugh a day. I try to find the unusual... after all you get the usual from all the other places!

July 05, 2008

Herpes Cure On The Way, Free Sex For Everyone!

DURHAM, N.C. – Now that Duke University
Medical Center scientists have figured out how the virus that causes
cold sores hides out, they may have a way to wake it up and kill it.

Cold sores, painful, unsightly
blemishes around the mouth, have so far evaded a cure or even
prevention. They're known to be caused by the herpes simplex virus 1
(HSV1), which lies dormant in the trigeminal nerve of the face until
triggered to reawaken by excessive sunlight, fever, or other stresses.

"We have provided a molecular
understanding of how HSV1 hides and then switches back and forth
between the latent (hidden) and active phases," said Bryan Cullen, Duke
professor of molecular genetics and microbiology.

His group's findings, published
in Nature, also provide a framework for studying other latent viruses,
such as the chicken pox virus, which can return later in life as a case
of shingles, and herpes simplex 2 virus, a genitally transmitted virus
that also causes painful sores, Cullen said.

Most of the time, HSV1 lives
quietly for years, out of reach of any therapy we have against it. It
does not replicate itself during this time and only produces one
molecular product, called latency associated transcript RNA or LAT RNA.

"It has always been a mystery
what this product, LAT RNA, does," Cullen said. "Usually viral RNAs
exist to make proteins that are of use to the virus, but this LAT RNA
is extremely unstable and does not make any proteins."

In studies of mice, the team
showed that the LAT RNA is processed into smaller strands, called
microRNAs, that block production of the proteins that make the virus
turn on active replication. As long as the supply of microRNAs is
sufficient, the virus stays dormant.

After a larger stress, however,
the virus starts making more messenger RNA than the supply of microRNAs
can block, and protein manufacturing begins again. This tips the
balance, and the virus ultimately makes proteins that begin active
viral replication.

The new supply of viruses then
travels back down the trigeminal nerve, to the site of the initial
infection at the mouth. A cold sore always erupts in the same place and
is the source of viruses that might infect another person, either from
direct contact, or sharing eating utensils or towels, Cullen said.

The approach to curing this
nuisance would be a combination therapy, Cullen said. "Inactive virus
is completely untouchable by any treatment we have. Unless you activate
the virus, you can't kill it," he said.

Cullen and his team are testing
a new drug designed to very precisely bind to the microRNAs that keep
the virus dormant. If it works, the virus would become activated and
start replicating.

Once the virus is active, a patient would then take acyclovir, a drug that effectively kills replicating HSV1.

"In principle, you could
activate and then kill all of the virus in a patient," Cullen said.
"This would completely cure a person, and you would never get another
cold sore."

He and the team are working
with drug development companies in animal trials to begin to answer
questions about how to deliver this drug most effectively.

Co-authors included Jennifer
Lin Umbach, Ph.D., and Heather W. Karnowski, B.S., of the Duke
Department of Molecular Genetics and Microbiology and Center for
Virology, and Martha F. Kramer, Igor Jurak, and Prof. Donald M. Coen of
the Department of Biological Chemistry and Molecular Pharmacology at
Harvard Medical School. This work was supported by two NIH grants.

I hope that it takes at least 5 years. After they determine the best way to give the drug (I am hoping a shot) and then they will need to do more animal studies and then go into clinical trials to determine if it is successful on humans. But to get a real concise answer to your questions, I would email the someone at Duke University.

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