In recent years, experts, politicians and the media have been talking about the phenomenon and possible harmfulness of new psychoactive substances (NPS) showing up in the European drug market. Besides the question of whether these substances are being used in recreational settings, this dynamic development is a challenge for the drug checking services. The panel “Drug Checking in a Dynamic Reality” will be presented by the European BAONPS and TEDI (NEW-Net) projects, and will focus on analysing results, analytical obstacles, new methods and developments related to the quality of substances, and to the reality that new psychoactive substances are being laced into more “classic” drugs.