Our overall research goal is focused on the development of a malaria transmission-blocking vaccine (TBV). The antigenic target, Pfs48/45 protein, is expressed on Plasmodium gametocytes, which are stages responsible for establishing parasite...

The development of an effective vaccine against HIV has been hampered by an incomplete understanding of the correlates of protection against the virus. It is generally accepted that robust antibody and cytotoxic T-lymphocyte (CTL) responses both...

Salmonella spp. pose significant health risks to humans and animals. S. Typhi, the causative agent of typhoid fever, is responsible for 21 million new cases of enteric fever each year and an estimated 200,000 deaths worldwide. Approximately 5-8% of...

Regulatory T cells (Tregs) suppress effector immune responses and have been implicated in promoting chronic viral infections. Their role during influenza infection and vaccination, however, is still unclear. Influenza is a major public health...