The present study was undertaken to evaluate
adaptogenic activity profile of a classical compound Ayurvedic formulation Amalakayas Rasayana in experimental
animals. AmalakayasRasayana (AR) was tested for its adaptogenic activity by
determining anti-stress and anti-ulcer activity in forced swimming induced
hypothermia and stress induced gastric ulcers. AR was administered in the dose
of 270 mg/kg orally for 7 consecutive days prior to forced swimming induced
hypothermia and stress ulcers. The adaptogenic and anti-ulcer activities were
assessed by determining and comparing the changes in rectal temperature,
ponderal changes, ulcer index, haematological parameters and anti-oxidant
activity in the test drug group with that of stress control group as well as
vehicle control group. In forced swimminghypothermia pre-treatment
with AR caused significant attenuation of rectal temperature when compared with
both stress control and vehicle control groups. It has shown a significant
reduction in ulcer index and lipid peroxidation. Moreover, AR did show a
significant increase in total glutathione content. Theresults suggest that AR possesses significant adaptogenic and anti-stress
activity which could be either due to attenuation of stress induced
stimulation of HPA axis and
cytoprotective action of the test formulation.

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