Abstracts and presentations are embargoed for release at date and time of presentation or time of AHA/ASA news event. Failure to honor embargo policies (http://newsroom.heart.org/newsmedia/embargo-policy) will result in the abstract being withdrawn and barred from presentation.

Jump to

Abstract

Introduction: The Post Cardiac Arrest syndrome (PCAS) cytokine storm is associated with mortality and neurological deficits. The magnitude of PCAS cytokine storm reflects the ischemic burden during CPR. We have demonstrated that increasing regional cerebral oxygenation (rSO2) levels during CPR are associated with ROSC and survival with favorable neurological outcomes.

Hypothesis: We hypothesize that higher rSO2 levels lead to improved CA outcomes by limiting ischemia, which in turn attenuates post resuscitation reperfusion injury and cytokine storm.

Methods: 26 ICU subjects had serum collected within 6hrs (t=0) and at 24 hrs after ROSC (day 1). We used a multiplex analysis to measure 34 cytokines including ILs 2, 8, 10, 11 ,12, Pentraxin, Interferons α , β and γ and soluble IL6 Receptor A (sIL6RA). rSO2 levels were collected during CPR (Nonin Equanox). We used a Pearson’s correlation and t-test to measure the association between rSO2 and post resuscitation cytokine release, as well as differences in cytokine levels in post-resuscitation subjects who survived to discharge with a favorable neurological outcome cerebral performance category (CPC) 1-2 vs. CPC 3-5 (death or severe neurological injury)