Highlights

Solutions

Creative Biolabs has a tradition of commitment. To achieve efficient execution and regulatory approval, we offer careful considerations of your program for the development of a cellular or gene therapy product – now and in the future.

Highlights

Platforms

To accelerate advanced breakthroughs of your projects, we offer broad range of platforms which enable our clients be free to tackle problems with cutting-edge technologies from different angles and in different methods.

Resources

Use the resources in our library to help you understand your options and make critical decisions for your study. We offer oncolytic virus, CAR-T, and dendritic cell related documents, as well as newsletter. If you don’t find the answers you’re looking for, contact us for additional assistance.

Highlights

Organoid-induced Differentiation of Conventional T Cells from hPSCs

Our collaborative approach and deep scientific and regulatory understanding of various drug discovery and development solutions helps us shape the best strategy for bringing a novel therapy to market and design custom studies and programs that reduce risk and accelerate timelines.

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Organoid-induced Differentiation of Conventional T Cells from hPSCs

As a world leader in CAR-T services, Creative Biolabs is dedicated to exploring more innovative and cutting-edge technologies to accelerate CAR-T discovery and development. Our scientists have extensive expertise in the field of CAR-T, and also stem cells to ensure strong knowledge basics. Both the experienced team and advanced platform enable us to provide comprehensive services to our clients in a diverse range.

Our Inspiration

CAR-T cell therapy has shown great efficacy in the treatment of hematological malignancies and even solid tumors and chronic viral infections, thus considering to be one of the most promising cancer immunotherapies. While some limitations need to be improved for making common CAR-T cells. For conventional CAR-T cell therapy, it’s very expensive since it’s specific for the patients. T cell is derived from the patients and then engineered to become CAR-T cell which will be injected back into the patient (see Fig.1). Hence, exploring novel strategies to generate conventional naïve T cells is meaningful to facilitate universal, off-the-shelf CAR-T cell products.

Based on the reported method to generate conventional T cells from human pluripotent stem cells (see Fig.2), our scientists are dedicated to establishing this platform which enables the potential to transform autologous T cell immunotherapy to universal, off-the-shelf cell products. We established the pluripotent stem cell (PSC)-artificial thymic organoid system to generate mature, functional T cells from human PSCs. We used this system to successfully generate naive CD3+CD8αβ+ and CD3+CD4+ conventional T cells with a diverse T cell receptor (TCR) repertoire. When an MHC class I-restricted TCR was introduced in PSCs, naïve and antigen-specific CD8αβ+ T cells can be produced. For this kind of CD8 T cells, there is no endogenous TCR expression, and they showed anti-tumor activity both in vitro and in vivo. This characterization ensures the generated T cells are functional and can be used for universal, off-the-shelf CAR-T cell products.

Highlights

This method is an efficient and standardized organoid system which can induce hematopoietic specification and conventional naïve T cell generation. Also, it enables the generation of naïve, antigen-specific T cells which hold anti-tumor activity.

Why choose Creative Biolabs

Advanced platform and senior scientists,

Short turnaround time with competitive price,

Collaboration between scientists across various areas,

Fully end-to-end solution provider.

This platform had been validated by our scientists via T cell in vitro and in vivo functional assays. Creative Biolabs is dedicated to advancing your CAR-T projects with versatile systems. We are committed to providing the most valuable and innovative solutions to our clients to facilitate your CAR-T projects. Our innovative and collaborative approach enables us to offer a broad range of services. If you are interested in any CAR-T related technologies, please feel free to contact us to learn how we can be involved in your projects.

Online Inquiry

For any technical issues or products/services related questions, please leave your contacts as below, and our team will contact you at earliest convenience to let you know how we can be involved in your projects.