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Supporting Information

Purpose of Ventilation

"Ventilation," as defined here, is the flow of outdoor air into a building. Mechanical ventilation is provided in many buildings, including most U.S. commercial buildings, using fans and ductwork that are part of heating, ventilating, and air conditioning (HVAC) systems. Natural ventilation is provided in some buildings (such as most homes) by airflows through open windows, doors, and other openings in the building's envelope which are driven by wind and indoor-outdoor temperature differences. Most U.S. homes do not have mechanical ventilation systems other than bathroom or kitchen exhaust fans that, when operated, provide mechanical ventilation. New homes with low-leakage envelopes more frequently have mechanical ventilation systems.

Ventilation dilutes indoor-generated air pollutants and flushes those pollutants out of a building. Ventilation also brings outdoor air pollutants into a building, although outdoor air typically has lower pollutant levels than indoor air and some of these outdoor pollutants may be removed from the ventilation air using filters. The quantity of ventilation air can impact the size of a building's HVAC equipment, and heating and cooling energy costs. In humid climates, ventilation air can introduce significant amounts of moisture to the indoor environment if not conditioned properly.

Ventilation Rate

The ventilation airflow rate is the rate of flow of outdoor air into a building per unit of time, and is often expressed in units of cubic feet per minute (cfm). "Ventilation rates" are normally expressed as ventilation airflow rates divided by the number of people in the building (yielding cfm per person), by the indoor air volume (yielding air changes per hour or h-1), or by the indoor floor area (yielding cfm per square ft.)

Sick Building Syndrome Symptoms

Sick Building Syndrome (SBS) symptoms are acute symptoms, such as irritation of eyes, nose, and throat, headache, fatigue, cough, and tight chest, that occur at work and improve when away from work. These symptoms can have multiple causes, thus, they do not indicate a specific type of disease or a specific type of pollutant exposure. SBS symptoms have been widely reported by occupants of offices and schools, and in a few studies by occupants of homes. Some occupants in every office building will report some SBS symptoms, but indoor environmental factors that are known or suspected to lead to increased SBS symptoms include a lower ventilation rate (throughout the normal ventilation rate range encountered in buildings), strong indoor pollutant sources, air conditioning, and higher indoor temperatures. The fraction of occupants experiencing SBS symptoms is often called the symptom prevalence or symptom prevalence rate.