The Mathematical Analyzer, Numerical Integrator And Computer did the calculations for ”Project Mike,” which produced the first hydrogen bomb. It was similar to the other IAS-inspired machines, though all were different enough that they could not exchange programs.

Lawrence Livermore National Laboratory used LARC, a custom-built supercomputer, to design bombs. Although only two were built, LARC spurred IBM’s "Stretch" project to compete in this new supercomputer class.