Purpose: :
Because of its high consumption of oxygen and its expositionto light, the retina is strongly susceptible to oxidative stress.8–oxoguanine (8–oxoG), which is the main DNA baselesion generated by oxygen free radicals, is excised by 8–oxoguanineglycosylase (OGG1) through base excision repair (BER). A recentstudy reported that this enzyme might protect photoreceptorsynaptic mitochondrial DNA in a model of light–inducedinjury. The purpose of the present study was to evaluate theeffect of basal lighting conditions on the retina of wild typeand OGG1–/– mice

Conclusions: :
This study demonstrates that mice retinal cellsexpress OGG1 and the main elements of the BER. We suggest that,in basal condition of oxygen free radicals generation, OGG1is not or poorly activated. Nevertheless, according to our preliminaryresults, OGG1 seems to be important is the maintenance of morphologicand functional retinal integrity.