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Human GM-CSF, along with other colony stimulating factors, are key drivers of differentiation and proliferation of hematopoietic precursors. GM-CSF increases leukocyte and reticulocyte counts and also recruits eosinophils, macrophages and neutrophils to sites of inflammation. GM-CSF is secreted by macorphages, mast cells, T cells, NK cells, endothelial cells and fibroblasts. Because of its potent ability to mobilize white blood cells, GM-CSF is used therapeutically to stimulate white blood cell production following chemotherapy.

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