Aims: Systemic scleroderma is a multiple chronic autoimmune disease that has important clinical and psychological consequences, including sexual dysfunction. The purpose of this study was to determine the efficacy of integrated treatment group on sexual function and its domains in women with scleroderma.Materials & Methods: This research was a semi-experimental design with pre-test, post-test, and follow-up with the experimental and control groups. The statistical population included women with scleroderma referred to Shariati Hospital in Tehran and Iran's Rheumatism Center in the second half of 2017. Of these, 30 patients were selected as available samples and randomly were placed in the control and the experimental groups. The experimental group was subjected to an integrated approach intervention in 9 sessions of 90-minutes, where as the control group did not receive such an intervention. The instrument of this study was the Female Sexual Function Index (FSFI) Questionnaire. Data were analyzed using SPSS24 software and repeated measures ANOVA.Findings: Unilateral psychotherapy intervention significantly increased the mean post-test of sexual function and its six sub-components in both control and experimental groups (p<0.01, F=19.59). The satisfaction component with 0.82 (p<0.01, F=125.35) and psychological stimulation with 0.74 (F=77.9, p<0.01) had the most effect on intervention, and the component of orgasm with 0.33 (F=13.54, p<0.01) had the least effect among the components. After three months, there was no statistically significant difference between the post-test and the follow-up of the experimental group, which indicated the stability of intervention effects.Conclusion: Unified psychotherapy is effective in increasing the sexual function of patients with systemic sclerosis and can play a significant role in improving the quality of life of these people.