Asthma Clinical Trials

The American Lung Association; National Institutes of Health/National Heart Lung Blood Institute

PI:

John Mastronarde, MD

Coordinator:

Joseph Santiago

Synopsis:

Our underlying hypothesis that asthma, although it may be initiated by allergic airway inflammation, is promoted by decreased tidal force fluctuations during recumbent sleep.

Protocol Name:

Long-acting Beta Agonist Step Down Study (LASST)

Sponsor:

The American Lung Association (ALA)

PI:

John Mastronarde, MD

Coordinator:

Joseph Santiago

Synopsis:

The primary goal is to perform a pragmatic study that resembles clinical practice and determine the optimal treatment strategy that results in the lowest rate of treatment failure over 48 weeks of follow-up.

Protocol Name:

Stimulation of the cervical sympathetic Ganglion for Treatment of Asthma.

Sponsor:

Neurosurgery / Asthma Center

PI:

Jonathan Parsons, MD

Coordinator:

Joseph Santiago

Synopsis:

The purpose of this study is to evaluate if stimulating the nerve involved with airway constriction, while undergoing procedures that are known to cause asthma exacerbations, decreases the level of asthma attack experienced.

Protocol Name:

The Asthma Registry for Contact and Possible Participation in a Future Asthma Research Study

Sponsor:

Pulmonary Division/ OSU Asthma Center

PI:

John Mastronarde, MD / Jonathan Parsons, MD

Coordinator:

Joseph Santiago

Synopsis:

Asthma registry for patients diagnosed with asthma who may be eligible for future studies.

Protocol Name:

Micro RNA signatures in acute asthma exacerbations

Sponsor:

Pulmonary Division/ OSU Asthma Center

PI:

John Mastronarde, MD

Coordinator:

Joseph Santiago

Synopsis:

This is a non-randomized, cohort study of the patterns of microvesicles in the serum of participants with atopic and non-atopic asthma.

Protocol Name:

Inflammatory Mediators and microRNA Analysis in Premenstrual Asthma

Sponsor:

National Institute of Health (NIH)

PI:

Jennifer McCallister, MD

Coordinator:

Joseph Santiago

Synopsis:

This study is being done to investigate the possible causes of this premenstrual increase in asthma symptoms and to help asthma care providers identify those patients who may suffer from this condition.

Protocol
Name:

Role of microRNA in Allergic Asthma Study

Sponsor:

Pulmonary Division/OSU Asthma Center

PI:

John Mastronarde, MD

Coordinator:

Joseph Santiago

Synopsis:

The purpose of this study is to investigate certain substances found in blood cells of persons with asthma and allergies.

Protocol Name:

Beta Agonist and IgE in Asthma Study.

Sponsor:

Pulmonary Division/OSU Asthma Center

PI:

John Mastronarde, MD

Coordinator:

Joseph Santiago

Synopsis:

The purpose of this study is to investigate certain substances found in the blood of persons with asthma and allergies, asthma without allergies and non-asthmatic without allergies.

This study is investigating how common it is for asthma and asthma-like symptoms to develop in people with HIV who are receiving HIV treatment with highly active antiretroviral therapy (HAART) compared to those who are not taking HAART

This study is investigating how common it is for asthma and asthma-like symptoms to occur in people with HIV who are receiving HIV treatment with highly active antiretroviral therapy (HAART) compared to those who are not taking HAART