Seagate Technology is about to release a HDD with hardware based encryption. These Full Disc Encryption (FDE) drives use 3DES algorithm in EDE (encrypt-decrypt-encrypt) mode using 3 different 64 bit keys. The effective key-length is 192 bit. Before the operating system boots, the user will be prompted to enter a password that will unlock the drive. You can always use 2-factor authentication instead of static password. Seagate's FDE drives can use biometric, RSA token, or smartcards. This was demo at CeBIT using TiDoCoMi from Secude.