> In 2011, an expert workgroup recommended newborn screening with Measure-through
Motion and Low Perfusion™ Pulse Oximetry to increase the detection of CCHD.1

> The CCHD workgroup cited the results of two large and independent prospective studies of 59,876 subjects
that exclusively used Masimo SET® Measure-through Motion and Low Perfusion Pulse
Oximetry2,3 to increase the identification of CCHD with minimal false positives.

• The Masimo YI infant sensor exclusively used in these two studies has an accuracy
specification** of ±2% in infants and ±3% in neonates.

>
The Eve Newborn Screening Software Application* in the Radical-7® Pulse CO-Oximeter automates
each of the screening steps with animated instruction, including sensor application,
measurement selection, and screening result determination.

> Institutions can also choose to add the Perfusion Index (PI) measurement available in all
Masimo SET® pulse oximeters to the screening criteria, which has been shown to help identify
CCHD or other illnesses not identified by physical exam or by SpO2 measurements alone.5

> Use of the Eve Newborn Screening Software Application* is intended to:

CUSTOMISATION

The screening protocol recommended by the CCHD workgroup is the default setting but can be customised to align with institution policy.

“Failing to follow and interpret a proper screening protocol, as well as being able to read measurements in newborns who are
often in motion and have low perfusion are factors that can make CCHD screening with pulse oximetry a challenge. The data
and study evidence show that having the right pulse oximetry technology for CCHD screening is critical - and it’s very exciting
to see the introduction of new tools that offer nurses a clearer, safer, more efficient way to conduct newborns screening and
protect newborn lives.”

Annamarie Saarinen, Co-Founder and CEO of the Newborn Foundation, and the mother of Eve, who was diagnosed at 48 hours old with CCHD

*** CCHD screening result is based on the protocol recommended by Kemper et al., Pediatrics, 2011. The screening result is not a definitive assessment of the patient’s CCHD condition.
The result should be evaluated in conjunction with the patient’s clinical status and confirmed with additional diagnostic tests consistent with each hospital’s policy.