X-Ray crystallographic structure and deletion mutagenesis of LacI have demonstrated that three-leucine-heptad repeats (LHR3), located at the C-terminus, are critical for dimer-dimer interaction to form tetramer. We are ...

LacI and PurR are members of the extended LacI/GalR family of bacterial proteins that regulate genetic expression. Detailed kinetic and thermodynamic studies on PurR were compared with results for homologous LacI. Operator ...