The cultivation of sugar cane produced in large scale demand large quantities of chemicals to control weeds, however for the correct use of herbicides it should be considered the stage of development of the weed community, climatic conditions and factors related to the soil. The objective of this study was to evaluate the control of five species of weeds and phytotoxicity to sugar cane, submitted to the use of herbicides applied in pre and post-emergence conditions, on the weeds, as well as the culture. The amicarbazone and isoxaflutole herbicides were applied at doses of: 0D; 1/64D; 1/32D; 1/16D, 1/8D, 1/4D, 1/2D, 1D and 2D, where D is the dose recommended for each herbicide in five species of weeds: Euphorbia heterophylla L., Sida rhombifolia L., Brachiaria decumbens Stapf, Digitaria horizontalis Willd e Panicum maximum Jacq., which were evaluated in a greenhouse. The same herbicides were evaluated in the field of commercial production of sugar cane, except P. maximum, however at doses of 1/2D, 1D, 2D and mixed with amicarbazone + isoxaflutole (1/2D + D). The dose used for the herbicide amicarbazone was 1.050 g i.a. ha-1 and 75 g i.a. ha-1 (greenhouse) and 112,5 g i.a. ha-1 (field) to isoxaflutole. The weed E. heterophylla was more susceptible by herbicide amicarbazone, while isoxaflutole required high doses to achieve adequate levels of control, in the greenhouse as well as in the field. S. rhombifolia was highly susceptible under greenhouse condition until 60 DAA, however in the field only the highest dose for each herbicide was enough to prevent the emergence of new streams of weed species at 150 DAA. The species of grasses B. decumbens and D. horizontalis were more susceptible to post-emergence; however in pre-emergence were more susceptible to isoxaflutole. For pre-emergence application in the field, the species of B. decumbens was susceptible by each herbicide applied separately at the highest dose. In post-emergence, B. decumbens did not achieve satisfactory effect in any of the herbicides applied. The species of D. horizontalis was few susceptible to the herbicide amicarbazone in pre-emergence in the field, opposite to what happened with the herbicide isoxaflutole. For P. maximum, the isoxaflutole was more efficient than the amicarbazone with only 1/4 of the recommended dose. Both herbicides were selective for sugar cane plants in all treatments, with only symptoms of phytotoxicity in the initial assessments, without interfering in the agricultural productivity of sugar cane for applications in pre-emergence of culture. However in post-emergence, the highest dose of herbicide amicarbazone caused reduction in sugar cane productivity.

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