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Genomic 'Haircut' Makes World's Tiniest Genome Even Smaller

The world's tiniest nuclear genome appears to have "snipped off the ends" of its chromosomes and evolved into a lean, mean, genome machine that infects human cells, according to research published September 21 by University of British Columbia scientists.

Until recently, E. cuniculi, a parasitic fungus commonly found in rabbits that can also be fatal to immunocompromised humans, has been widely regarded as having the smallest known nuclear genome. At 2.9 millions base pairs (Mbp) and approximately 2,000 genes, the genome of E. cuniculi is less than one-two thousandth the size of the human genome.

But now, a team of researchers led by UBC Botany Prof. Patrick Keeling sequenced the genome of a closely related parasite that makes the E. cuniculi genome seem positively king-sized. The genome of E. intestinalis, a sister species of E. cuniculi that infects human intestines, is 20 per cent smaller, at only 2.3Mbp.

"On one end of the spectrum, genomes can get larger almost without limit, but there is a limit to how small they can get -- they can't be less than zero," says Keeling, whose work is published in the September 21 issue of the journal Nature Communications. "And the question that fascinated us was 'in an already tiny genome, what else can be lost'?"

Keeling and a team of researchers from Switzerland, Canada and the U.S. compared the genome of E. cuniculi and E. intestinalis and found little difference between the chromosome "cores" but that the ends were all "trimmed" in E. intestinalis.