Brefeldin A is a macrocyclic lactone from fungal source, exhibiting a wide range of antibiotic activity.

Molecular weight:

280.40

InChl Key:

KQNZDYYTLMIZCT-HHMYAMTESA-N

Canonical SMILES:

CC1CCCC=CC2CC(CC2C(C=CC(=O)O1)O)O

Isomeric SMILES:

C[C@H]1CCC/C=C/[C@@H]2C[C@@H](C[C@H]2[C@@H](/C=C\C(=O)O1)O)O

Further Information

Solubility ( literature ):

Methanol, Ethanol, Dichloromethane, DMSO, acetone or ethyl acetate

Compound Classification:

Macrocyclic lactone antibiotic.

Antifungal

Antiviral

Protein Synthesis Inhibitor

Storage, handling:

Store in a freezer upon arrival, at -10°C to -25°C

Open carefully.

Use the original container to store the product.

Keep the lid tightly closed.

Avoid exposing to strong direct light.

Other vendors may recommend higher temperatures for storage.

Applications:

Inhibitor of protein translocation from endoplasmic reticulum (ER) to the Golgi apparatus.Inhibitor of intracellular protein transport and protein secretionA macrolide isolated from Penicillium brefeldianum. It affects the vesticular transport of the Golgi apparatus and induces DNA fragmentation which leads to apoptosis.