At a news conference at the United States Department of Justice (DOJ) on August 6, 2008, FBI and DOJ officials formally announced that the Government had concluded that Ivins was likely to have been solely responsible for "the deaths of five persons, and the injury of dozens of others, resulting from the mailings of several anonymous letters to members of Congress and members of the media in September and October 2001, which letters contained Bacillus anthracis, commonly referred to as anthrax."[7][8] On February 19, 2010, the FBI released a 92-page summary of evidence against Ivins and announced that it had concluded its investigation.[9][10] The FBI conclusions have been contested by many, including senior microbiologists, the widow of one of the victims,[11] and several prominent American politicians. U.S. Senator Patrick Leahy (D-VT) who was among the targets in the attack, Senator Chuck Grassley (R-IA), former Senator Arlen Specter (R-PA), Representative Rush Holt (D-NJ), and Representative Jerrold Nadler (D-NY)[6][12][13] all argued that Ivins was not solely responsible for the attacks.

The FBI subsequently requested a panel from the National Academy of Sciences to review its scientific work on the case.[14] On May 15, 2011, the panel released its findings, which "conclude[d] that the bureau overstated the strength of genetic analysis linking the mailed anthrax to a supply kept by Bruce E. Ivins."[6][15] The committee stated that its primary finding was that "It is not possible to reach a definitive conclusion about the origins of the B. anthracis in the mailings based on the available scientific evidence alone."[12][13][16][17][18][19][20][21]

Bruce Ivins was born, and spent his youth, in Lebanon, Ohio, a small town 30 miles northeast of Cincinnati.[22] His parents were Thomas Randall Ivins and Mary Johnson (nee Knight) Ivins, and he was the youngest of three sons.[1] His father, a pharmacist, owned a drugstore and was active in the local Rotary Club and Chamber of Commerce, while his mother participated in the Parent-Teacher Association. The family went regularly to Lebanon Presbyterian Church, although Ivins was later a Catholic parishioner.[23] According to C.W. Ivins, one of Ivins' elder brothers, their mother Mary was violent and physically abusive to all three children. When she discovered she was pregnant with Bruce, a pregnancy that was unplanned and unwanted, she repeatedly tried to abort the child by throwing herself down a set of stairs. Ivins would eventually hear the story of his mother's attempt to abort him.[22]

Avidly interested in science, Ivins was an active participant in extracurricular activities in high school, including National Honor Society, science fairs, the current events club, and the scholarship team all four years. He ran on the track and cross-country teams, worked on the yearbook and school newspaper, and was in the school choir and junior and senior class plays.[23]

In December 1975, Ivans married nursing student Mary Diane Betsch (known as Diane), to whom he remained married until his death.[1][24] The couple had two children.[1][23][25] Diane Ivins was a homemaker and full time parent who also ran a daycare center out of the family's home.[26] His wife, children, and brothers were all still alive at the time of his death; his parents were deceased.[1]

Ivins graduated with honors from the University of Cincinnati with a B.S. degree in 1968, an M.S. degree in 1971, and a Ph.D. degree in 1976, all in microbiology.[2] Ivins conducted his Ph.D. research under the supervision of Dr. P. F. Bonventre. His dissertation focused on different aspects of toxicity in disease-causing bacteria.[23]

Ivins had published at least 44 scientific papers dating back to May 18, 1969.[27][28] His earliest known published work pertained to the response of peritonealmacrophages, a type of white blood cell, to infection by Chlamydia psittaci, an infectious bacterium that can be transmitted from animals to humans.[29][30] He was the co-author of numerous anthrax studies, including one on a treatment for inhalational anthrax published in the July 7, 2008 issue of the journal Antimicrobial Agents and Chemotherapy.[5] He often cited the 2001 Anthrax attacks in his papers to bolster the significance of his research in years subsequent to the attacks.[31] In a 2006 paper published in the prestigious journal Proceedings of the National Academy of Sciences, he wrote with his co-authors

Shortening the duration of antibiotic postexposure prophylaxis in a bioterrorism event involving B. anthracis by adding postexposure vaccination could greatly alleviate problems of noncompliance and side effects associated with prolonged antibiotic therapy. The value of adding vaccination to postexposure antibiotic prophylaxis should be considered in planning the public health response to bioterrorism events involving inhalational anthrax.[31]

Ivins was a co-inventor on two United States patents for anthrax vaccine technology, U.S. Patent 6,316,006 and U.S. Patent 6,387,665. Both of these patents are owned by his employer at the time, the United States Army.

Ivins was a Roman Catholic. The Frederick News-Post has made public several letters to the editor written by Ivins dealing with his religious views.[33] These were cited in the Department of Justice summary of the case against Ivins as suggesting that he may have harbored a grudge against pro-choice Catholic senators Daschle and Leahy, recipients of anthrax mailings.[34] In a letter expressing his belief that Jews were God's chosen people, Ivins stated, "By blood and faith, Jews are God's chosen, and have no need for 'dialogue' with any gentile."[35] Ivins praised a rabbi for refusing a dialogue with a Muslim cleric.[35]

His pastimes included playing keyboard at his local church, Saint John the Evangelist;[1] he was a member of the American Red Cross;[1] he was an avid juggler and founder of the Frederick Jugglers.[23] He played keyboards in a Celtic band and would often compose and play songs for coworkers who were moving to new jobs.[23][25]

Ivins became involved in the investigation of the 2001 anthrax attacks because he was regarded as a skilled microbiologist.[2] Starting in mid-October, Ivins and his colleagues worked long hours testing samples to distinguish real anthrax letters from the numerous hoaxes that were sent out at this time.[39] Ivins also helped the FBI analyze the powdery material recovered from one of the anthrax-tainted envelopes sent to a U.S. senator's office in Washington, D.C.[2]

Results of the investigation were initially distributed to the public via ABC News claiming "four well placed sources" attesting to the fact that "trace amounts of the chemical additives bentonite" were found in the anthrax samples, and that this was the chemical signatures of Iraqi-made anthrax.[36] It has been confirmed that bentonite was never actually found in the anthrax samples.[36] While it is presumed that Ivins was one of ABC News' four sources, ABC News has refused to reveal their identities, which has contributed to the mystery of Ivins' role in the initial investigation and its widely reported findings.[36]

In 2002, an investigation was carried out as a result of an incident at Fort Detrick where anthrax spores had escaped carefully guarded rooms into the building’s unprotected areas.[40] The incident called into question the ability of USAMRIID to keep its deadly agents within laboratory walls seven months after the anthrax mailings.

A coworker reportedly told Ivins that she was concerned she was exposed to anthrax spores when handling an anthrax-contaminated letter. Ivins tested the technician’s desk area that December and found growth that had the earmarks of anthrax. He decontaminated her desk, computer, keypad and monitor, but did not notify his superiors.[40]

For six years, the FBI focused its investigation on Steven Hatfill, considering him to be the chief suspect in the attacks. In March 2008, however, authorities exonerated Hatfill and settled the lawsuit he initiated for $5.8 million.[41] According to ABC News, some in the FBI considered Ivins a suspect as early as 2002.[42] FBI Director Robert S. Mueller III changed leadership of the investigation in late 2006, and at that time Ivins became the main focus of the investigation.[2]

After Hatfill was no longer considered a suspect, Ivins began "showing signs of serious strain".[43] As a result of his changed behavior, he lost access to sensitive areas at his job. He began being treated for depression and expressed some suicidal thoughts.[2] On March 19, 2008 police were summoned to Ivins' home in Frederick, MD, found him unconscious and sent him to the hospital.[23]

In June 2008, Ivins was involuntarily committed to a psychiatric hospital. The FBI said that during a June 5 group therapy session there, Ivins had a conversation with a witness, during which he made a series of statements about the anthrax mailings that the FBI said could best be characterized as "non-denial denials".[44] When asked about the anthrax attacks and whether he could have had anything to do with them, the FBI said that Ivins admitted he suffered from loss of memory, stating that he would wake up dressed and wonder if he had gone out during the night. His responses allegedly included the following:

"I can tell you I don't have it in my heart to kill anybody"

"I do not have any recollection of ever have doing anything like that. As a matter of fact, I don’t have no clue how to, how to make a bio-weapon and I don’t want to know."

"I can tell you, I am not a killer at heart"

"If I found out I was involved in some way, and, and ..."

"I don't think of myself as a vicious, a, a nasty evil person."

"I don't like to hurt people, accidentally, in, in any way. And [several scientists at USAMRIID] wouldn't do that. And I, in my right mind wouldn't do it [laughs] ... But it's still, but I still feel responsibility because it [the anthrax] wasn't locked up at the time ..."

Late in July 2008, investigators informed Ivins of his impending prosecution for his alleged involvement in the 2001 anthrax attacks that Ivins himself had previously assisted authorities in investigating. It has been reported that the death penalty would have been sought in the case.[45] Ivins maintained his security clearance until July 10; he had been publicly critical of the laboratory's security procedures for several years.[46]

Dr. W. Russell Byrne, a colleague who worked in the bacteriology division of the Fort Detrick research facility, said FBI agents "hounded" Ivins by twice raiding his home and that Ivins had been hospitalized for depression earlier in the month.[47] According to Byrne and local police, Ivins had been removed from his workplace out of fears that he might harm himself or others. "I think he was just psychologically exhausted by the whole process", Byrne said.[48] "There are people who you just know are ticking bombs", Byrne said. "He was not one of them."[49] However, Tom Ivins, who last spoke to his brother in 1985, said, "It makes sense ... he considered himself like a god".[50][51]

The Los Angeles Times asserted that Ivins stood to profit from the attacks because he was a co-inventor on two patents for a genetically-engineered anthrax vaccine. The San Francisco-area biotechnology company, VaxGen, licensed the vaccine and won a federal contract valued at $877.5 million to provide the vaccine under the Project Bioshield Act.[52] However, biological warfare and anthrax vaccine expert Dr. Meryl Nass has expressed skepticism of this purported motive, pointing out that "Historically, government employees do not receive these royalties: the government does."[53]

On August 6, 2008, a federal prosecutor, U.S. Attorney Jeffrey Taylor, officially made a statement that Ivins was the "sole culprit" in the 2001 anthrax attacks.[54] Taylor stated that Ivins had submitted false anthrax evidence to throw investigators off of his trail, was unable to adequately explain his late laboratory working hours around the time of the attacks, tried to frame his co-workers, had immunized himself against anthrax in early September 2001, was one of more than 100 people with access to the same strain of anthrax used in the killings, and had used similar language in an email to that in one of the anthrax mailings.[55] Ivins was also reportedly upset that the anthrax vaccine, that he had spent years helping develop, was being pulled from the market.[56]

On the morning of July 27, 2008, Ivins was found unconscious at his home. He was taken to Frederick Memorial Hospital and died on July 29 from an overdose of Tylenol with codeine,[5][57] an apparent suicide. No autopsy was ordered following his death because, according to an officer in the local police department, the state medical examiner "determined that an autopsy wouldn't be necessary" based on laboratory test results of blood taken from the body.[58] A summary of the police report of his death, released in 2009, lists the cause of death as liver and kidney failure, citing his purchase of two bottles of Tylenol PM (containing diphenhydramine), contradicting earlier reports of Tylenol with codeine.[59] His family declined to put him on the liver transplant list, and he was removed from life support.[59]

Immediately after news of his death, the FBI refused to comment on the situation.[5] Ivins' attorney released a statement asserting that Ivins had co-operated with the six-year investigation by the FBI and also asserting that Ivins was innocent in the deaths.[60]

Paul Kemp, Ivins' attorney, stated that the US government's case against his client is not convincing. US Department of Justice official Dean Boyd stated that Ivins mailed anthrax to NBC in retaliation for an investigation of Ivins' laboratory's work on anthrax conducted by Gary Matsumoto, a former NBC news journalist. At the time, however, Matsumoto was working for ABC, not NBC. Also, Ivins passed a polygraph-assisted interrogation (also known as a "lie detector test") in which he was questioned about his possible participation in the anthrax attacks. Boyd responded by saying that the FBI now believes that Ivins used countermeasures to deceive the polygraph examiners. "There are clearly a lot of unanswered questions," said Iowa Senator Chuck Grassley, who is calling for a congressional investigation into the allegations that Ivins was the anthrax killer.[61]

Those who argue for Ivins' innocence claim that the anthrax used in the attacks was too sophisticated to be produced by a lone researcher without relevant training. "In my opinion, there are maybe four or five people in the whole country who might be able to make this stuff, and I'm one of them," said Richard O. Spertzel, former deputy commander of USAMRIID.[62] "And even with a good lab and staff to help run it, it might take me a year to come up with a product as good."[62] The spores in the Daschle letter were 1.5 to 3 micrometres across, many times smaller than the finest known grade of anthrax produced by either the U.S. or Soviet bioweapons programs.[62] An electron microscope, which costs hundreds of thousands of dollars, would be needed to verify that the target spore size had been consistently achieved.[62] The presence of the anti-clumping additive silicon in the anthrax samples also suggests a high degree of sophistication as specialists working at Lawrence Livermore National Laboratory were unable to duplicate this property despite 56 attempts.[63]

While not outright rejecting the theory of Ivins' involvement, Patrick Leahy has asserted that "If he is the one who sent the letter, I do not believe in any way, shape or manner that he is the only person involved in this attack on Congress and the American people. I do not believe that at all."[64]

Ivins was reportedly obsessed with the college sororityKappa Kappa Gamma (KKG) ever since he was rebuffed by a woman in the sorority during his days as a student at the University of Cincinnati.[65][66] According to The Smoking Gun, U.S. Government court documents stated that Ivins edited the KKG article in Wikipedia using the account name "Jimmyflathead", by which he made a number of edits that put derogatory information about the sorority into the article and engaged in some disputes and discussions[67][68] about the content of the article.[68][69]

The FBI claims, because anthrax spores were found in a postal drop box located 300 feet (91 m) away from Princeton University's Kappa Kappa Gamma storage facility (where the Sorority keeps rush paraphernalia, initiation robes and other materials), that the anthrax laced letters had been mailed from that drop box.[70] As of this date,[when?] leaks from the law enforcement community claim they have not been able to place Ivins in Princeton the day the letters were mailed. Katherine Breckinridge Graham, an advisor to Kappa's Princeton chapter, stated that there was nothing to indicate that any of the sorority members had anything to do with Ivins.[66] Officials claim that the sorority link helps explain why the letters were mailed from Princeton, 200 miles (320 km) from the Fort Detrick laboratory in Frederick, Maryland, where Ivins worked and where it is claimed the anthrax was produced.

A United States government investigative panel, called the Expert Behavioral Analysis Panel, issued a report in March 2011 which detailed more of Ivins' obsession with the sorority. According to the panel's report, Ivins tormented a sorority member at the University of North Carolina named Nancy Haigwood. Ivins stole her notebook, which documented her research for her doctoral studies, and vandalized her residence.[71]

On August 6, 2008, the FBI released a collection of emails written by Ivins.[72] In some, Ivins describes episodes of anxiety, paranoia, and depression for which he was medicated;[34] these are referenced in the summary of the case against Ivins. A clinical psychiatrist engaged by The New York Times to analyze the released documents found evidence of psychoses, but could not rule out that the possibility that Ivins was feigning or exaggerating mental illness for purposes of attention or sympathy.[73]

A United States government investigative panel, called the Expert Behavioral Analysis Panel, issued a report in March 2011 which detailed more of Ivins' mental health issues. According to the panel's report, the Army did not examine Ivins' background adequately before clearing him to work with anthrax: such clearance should not have been given. The report endorses the government's implication of Ivins: circumstantial evidence from Ivins' psychiatric history supported the conclusion that Ivins was the anthrax killer.[71][74][75]

One of the most contested elements of the Ivins case involves the testimony of his former therapist, social worker Jean C. Duley. Documents show that Ivins was ordered late in July 2008 to stay away from Duley,[76] In her handwritten application for a protective order, Duley wrote that Ivins had stalked and threatened to kill her and had a long history of homicidal threats.[23] However, in her testimony, Duley also stated that she had only known Ivins for six months.[77]

Duley had been set to give testimony against Ivins on August 1, 2008.[50] Ivins, however, had no criminal record, whereas Duley herself has a history of convictions for driving under the influence and charges of battery by her ex-husband.[78] The charges forced her to quit her job, and attorney costs used up her savings, according to her fiance.[78] In a 1999 newspaper interview, Duley described herself as a former motorcycle gang member and drug user: "Heroin. Cocaine. PCP. You name it, I did it."[79] According to an article originally appearing in the August 12, 2009 Frederick News-Post, Duley was under house arrest when she tape recorded Ivins' allegedly "threatening" messages.[80] The Frederick News-Post also made available a recording of the allegedly threatening calls.[81] The nature of the actual audio recordings was characterized in the published report as "No threats are made or implied in the messages. More the sad ramblings of a broken man who felt betrayed."[80]

In her July 2008 restraining order Duley alleged that Ivins "has a history dating to his graduate days of homicidal threats, actions, plans, threats & actions towards theripist" (sic). According to Duley, "Dr. David Irwin his psychiatrist called him homicidal, sociopathic with clear intentions" (sic) and she would "tetisfy with other details" (sic).[82] She further alleged a "detailed homicidal plan" to kill his co-workers after learning he was going to be indicted on capital murder charges and stated that, upon hearing of his possible indictment, Ivins had purchased a gun and a bulletproof vest.[83] Ivins was subsequently committed for psychiatric evaluation, and his home was raided by federal agents who confiscated ammunition and a bulletproof vest.[84] He was released from his committal on July 24, five days before his death.

Dr. Henry S. Heine, a microbiologist who was Ivins' fellow researcher at the Army Medical Research Institute, told a National Academy of Sciences panel on April 22, 2010 that he considered it impossible that Ivins could have produced the anthrax used in the attacks without detection.[14]

Heine told the 16-member National Academy of Sciences panel that producing the quantity of spores in the letters would have taken at least a year of intensive work using the equipment at the U.S. Army laboratory. Such an effort would not have escaped colleagues’ notice, and laboratory technicians who worked closely with Dr. Ivins have told him they saw no such work.[14]

Heine also disputed the notion that biological containment measures where Dr. Ivins worked were inadequate to prevent the spores from floating out of the laboratory into animal cages and offices. He told the panel that if the containment was inadequate, "You’d have had dead animals or dead people".[14]

Heine said he did not dispute that there was a genetic link between the spores in the letters and the anthrax in Ivins’ flask, which led the FBI to conclude that Ivins had grown the spores from a sample taken from the flask. Heine pointed out that samples from the flask were widely shared. Accusing Ivins of the attacks, he said, was like tracing a murder to the clerk at the sporting goods shop who sold the bullets.[14]

Asked by reporters after his testimony whether he believed there was any chance that Ivins had carried out the attacks, Heine replied, “Absolutely not.” At the Army’s biodefense laboratory, he said, “among the senior scientists, no one believes it.”[14]

The FBI asked the National Academy of Sciences to review the FBI's scientific work on the case. A panel was created, chaired by Alice P. Gast, president of Lehigh University.[14] On May 15, 2011 the panel released its findings, which "conclude[d] that the bureau overstated the strength of genetic analysis linking the mailed anthrax to a supply kept by Bruce E. Ivins."[6]

Following the release of a National Academy of Sciences report in February 2011, Congressman Rush D. Holt, Jr. (D-NJ), a physicist from whose district the anthrax letters were mailed, re-introduced legislation "to create a 9/11-style Commission, complete with subpoena power, with a mandate to review the entire matter."[6] Senator Chuck Grassley of Iowa told The Washington Post: "There are no more excuses for avoiding an independent review."[6] Blogger Glenn Greenwald, who has been vocal in his criticism of the anthrax investigation,[78][85][86][87][88] argued that "[o]ther than a desire to avoid finding out who the culprit was (or to avoid having the FBI's case against Ivins subjected to scrutiny), there's no rational reason to oppose an independent investigation into this matter."[6]

In 2011, journalist David Willman's book on Ivins, The Mirage Man: Bruce Ivins, the Anthrax Attacks, and America's Rush to War, was published. The book details Ivin's troubled history and mental problems.[89]

^ abcdJordan, Lara Jakes; David Dishneau (2008-08-01). "Anthrax scientist commits suicide as FBI closes in". Associated Press. Retrieved 2008-08-01. A top U.S. biodefense researcher apparently committed suicide just as the Justice Department was about to file criminal charges against him in the anthrax mailings that traumatized the nation in the weeks following the Sept. 11, 2001, terrorist attacks, according to a published report.[dead link]

^Ross, Brian (August 1, 2008). "Anthrax Suspect Under Scrutiny Since 2002". ABC News. Retrieved 2008-08-03. Bruce E. Ivins, had been under suspicion by some FBI agents since early 2002 when anthrax spores were found near his desk, but FBI supervisors were more focused then on another scientist, Steven Hatfill, and dismissed concerns about Ivins, federal law enforcement sources tell ABC News.

^Lipton, Eric (August 6, 2008). "In Anthrax Scientist's E-Mail, Hints of Delusions". The New York Times. Retrieved 2009-01-05. Richard G. Rappaport, an associate clinical psychiatry professor at the University of California, San Diego, who examined the court papers at the request of The New York Times, said Dr. Ivins appeared to exhibit psychotic characteristics. It was possible, Dr. Rappaport said, that he was faking his mental ailment, in an effort to draw attention to himself. But he said he wondered why Dr. Ivins had been allowed to continue to work for so long in a high-security biodefense laboratory.