Who has the edge? Buffalo Bills at Miami Dolphins

Lynne Sladky / AP

RB Jay Ajayi (204 yards vs. Pittsburgh) is coming off a career-best performance. But the real star in this category might be the OL, which made its debut with the starting lineup of C Mike Pouncey, LG Laremy Tunsil, RG Jermon Bushrod, LT Branden Albert and RT Ja’Wuan James. They cleared the way for a 222-yard rushing day. Buffalo, led by LBs Zach Brown (68 tackles, 2nd in NFL) and Preston Brown (53 tackles, tied for 8th in NFL) and DT Kyle Williams, could get DT Marcell Dareus (suspension/injury) for his season debut and that would be huge. The Dolphins are 20th in the NFL in rushing at 97.3 yards per game while the Bills are 19th in run defense 103.2 yards per game. EDGE: Dolphins

RB Jay Ajayi (204 yards vs. Pittsburgh) is coming off a career-best performance. But the real star in this category might be the OL, which made its debut with the starting lineup of C Mike Pouncey, LG Laremy Tunsil, RG Jermon Bushrod, LT Branden Albert and RT Ja’Wuan James. They cleared the way for a 222-yard rushing day. Buffalo, led by LBs Zach Brown (68 tackles, 2nd in NFL) and Preston Brown (53 tackles, tied for 8th in NFL) and DT Kyle Williams, could get DT Marcell Dareus (suspension/injury) for his season debut and that would be huge. The Dolphins are 20th in the NFL in rushing at 97.3 yards per game while the Bills are 19th in run defense 103.2 yards per game. EDGE: Dolphins

This is perhaps the most pivotal matchup of the game. The Dolphins are without Pro Bowl S Reshad Jones (shoulder/injured reserve), one of their best tacklers. Buffalo rushed for 312 yards last week against San Francisco and is No. 1 in the NFL at 166.3 yards per game. The Dolphins are 31st in the NFL in rushing defense at 147 yards per game. However, the Miami defense will have its challenge mitigated by the Bills' loss of RB LeSean McCoy (hamstring). McCoy is second in the NFL in rushing yards (587) and tied for second in rushing TDs (6). If Buffalo runs the ball effectively it likely controls time of possession and forces the Dolphins to pass as opposed to the Dolphins electing to pass. EDGE: Bills

This is perhaps the most pivotal matchup of the game. The Dolphins are without Pro Bowl S Reshad Jones (shoulder/injured reserve), one of their best tacklers. Buffalo rushed for 312 yards last week against San Francisco and is No. 1 in the NFL at 166.3 yards per game. The Dolphins are 31st in the NFL in rushing defense at 147 yards per game. However, the Miami defense will have its challenge mitigated by the Bills' loss of RB LeSean McCoy (hamstring). McCoy is second in the NFL in rushing yards (587) and tied for second in rushing TDs (6). If Buffalo runs the ball effectively it likely controls time of possession and forces the Dolphins to pass as opposed to the Dolphins electing to pass. EDGE: Bills