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In a country of free-thinking, brainwashing is common word, with bad meaning. In China, some people even don't understanding the meaning of it, that is really a sad of brainwashing. It is a good word here, make me laugh...

Those are all serious, and some of them apply to humanity in general, some of them to individuals. Not everyone gets cheated on, so forth. I think one that is also serious, and individual, would have to be illness that shows no sign of stopping, be it physical or mental. It wears a person down.