The wrist injury that frequently results from attempting to play "Through the Fire and Flames" by Dragonforce, on Guitar Hero 3. It's a combination of both carpal tunnel and a sprain in the left wrist, sometimes accompanied by a slow dull ache in the right wrist.
The only way to avoid Dragonforce wrist is to never attempt playing "Through the Fire and Flames". However, since this is nearly impossible for the red-blooded Guitar Hero loving American male, an hour long break may ease the pain.

Slash has Dragonforce wrist even though he owned the song and the game blew to freaking pieces because of his awesome guitar wizardry.