Saw my NMS who said I could try Lyrica.. He started me out slow - 25 mg three times a day. Handled it well - no side effects to report. He said to keep it there for a week then slowly move up to 100 mg three times a day. I did that. Side effects were fairly minimal - only one that was somewhat bothersome was dizziness - but this only occurred with the morning doses. Definitely helped my twitches - but did nothing for the tiredness, soreness symptoms. For me, I could handle the twitches - I wanted something for the other symptoms. So I tried it for 3 weeks total. Decided to quit because it was hard to remember to take - especially the afternoon dose.