When Melanie (Valerie Bertinelli), Joy (Jane Leeves) and Victoria (Wendie Malick) try to join a prestigious Cleveland country club, they discover that Elka (Betty White) has a long history with the club’s president (Golden Globe� Award-winner Ed Asner, MARY TYLER MOORE), and he’s bent on revenge.

The ladies escape to a lake house after Victoria (Wendie Malick) sets loose a poisonous spider belonging to her ex-husband. Then, Melanie (Valerie Bertinelli) finds out her new love interest is actually Joy’s (Jane Leeves) former fiance.

When Johnny Revere records a benefit song in Cleveland, Victoria (Wendie Malick) assumes they’ll pick up where they left off. Melanie tracks a musical idol, Elka (Betty White) seeks a lock of a singer’s hair for her charity and Joy (Jane Leeves) chases her fantasy of being a rock star.

Victoria’s (Wendie Malick) arch nemesis Susan Lucci arrives looking for guidance now that ALL MY CHILDREN has been cancelled. When Susan makes the other ladies wishes come true, they fall for her, despite Victoria’s warnings that they’ll all get “Luccied.”

On Elka’s (Betty White) birthday, Melanie (Valerie Bertinelli) takes her to the Browns football team’s locker room and ends up dating the kicker. Meanwhile, Joy (Jane Leeves) and Elka get some surprising medical news after a near-death experience.

When Joy (Jane Leeves) and Elka (Betty White) learn that their combined scents are an aphrodisiac for the nearly extinct Black Rhinos, they’re forced to live together at the Cleveland zoo until the species is saved.