A vaccine-focused biotechnology company approached LIGHTHOUSE to help investigate a phenomenon observed in liquid vaccine product stored at -80°C. During QC testing, a number of vials were found to have an overpressure. This phenomenon represented a serious safety risk and LIGHTHOUSE was asked to support an investigation to identify the root cause.

This application note describes how laser-based headspace analysis is used for the rapid non-destructive determination of headspace oxygen levels in pre-filled syringes. Data is presented demonstrating two major applications of this technique: 1) headspace oxygen monitoring on a pre-filled syringe line filling oxygen-sensitive product, and 2) container closure testing of pre-filled syringes.

How non-destructive headspace analysis information can be critical for QC groups performing stability studies, or for packaging development groups responsible for choosing the optimal primary packaging configuration.

Top-down X-ray scanners inspect the product from above and for this the camera taking the image is located underneath the conveyor belt. This construction is always chosen when the height of the products is low compared to their surface area.

WIPOTEC-OCS provides a reliable and robust combination of checkweigher and metal detection in an innovative, hygienic Wash Down design. This model meets all statutory provisions for the food processing industry like IFS-compliant product control, and HACCP or LMHV/FDA (Food Hygiene Regulations).

The HC-A-MDi checkweigher / metal detector model is synonymous with high precision weighing in combination with extremely sensitive metal detection for optimal performance. It is a practical combination of inspection technologies in the interests of increased consumer safety and provides scales and metal detector in one space-saving unit, which can be operated from one HMI and easily integrated as part of any line.

Aseptic sampling devices are a critical component in an effective microbial control program. Samples collected with TAKEONE® are used to measure critical purity attributes such as bioburden, sterility and endotoxin levels and important process parameters like metabolites, nutrients, osmolality, pH and more. The TAKEONE® aseptic sampling device is a pre-assembled and single-use sampling solution. The 1,5" or 2" device has 5 or 9 fully-closed and independent sampling lines. TAKEONE® collects perfectly representative samples giving exact results with no risk of false positives.

GlobalVision Color Inspection is the first digital inspection solution for color management for PDFs and printed components. The tool inspects colors and reports any differences outside a defined color threshold. Instead of manually checking colors by eye, users can detect and communicate color differences with color reports alongside their proofs for approval.