Specifications

Usage & Assay Information

Usage Recommendations

ELISA: 0.5-2 ug/ml, Inhibition: 0.9-1.3 ug/ml, WB: 0.1-0.2 ug/ml

Storage & Safety

Storage

Store at -20 deg C until reconstitution. Following reconstitution product may be stored at 4 deg C in the short term. For long term storage aliquot and freeze at -20 deg C. Avoid repeated freeze/thaw cycles.

General Information

Biological Significance

The originally described IL17 protein, now known as IL17A, is a homodimer of two 136 amino acid chains, secreted by activated T-cells that act on stromal cells to induce production of proinflammatory and hematopoietic bioactive molecules. Today, IL17 represents a family of structurally-related cytokines that share a highly conserved C-terminal region but differ from one another in their N-terminal regions and in their distinct biological roles. The six known members of this family, IL17A through IL17F, are secreted as homodimers. IL17A exhibits cross-species bioactivity between human and Mouse cells.