*Percentage decrease or increase in cell population numbers compared with normal controls.
†Percentage of cell population marked for DTA-mediated deletion by the yellow fluorescent
protein marker (YFP). ‡Determined by loss of BrdU-labeled cells, which might also be influenced by dilution
of label following proliferation. ND, not done; ≈, approximately equal to normal controls;
↑, increased compared with normal controls; §The increase in BrdU labeling was too low to be determined. The method by which cell
turnover was assessed is indicated: BrdU, bromodeoxyuridine, is incorporated into
the DNA of proliferating cells upon administration to mice; CFSE, carboxyfluorescein
succinimidyl ester, is diluted out from adoptively transferred CFSE-labeled cells
with each successive division; Ki67, a protein that is expressed in the nucleus of
recently divided cells.