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The journey of resveratrol from yeast to human.

The natural polyphenolic compound resveratrol was first discovered in the 1940s. In the recent years, this compound received renewed interest as several findings implicated resveratrol as a potent SIRT1 activator capable of mimicking the effects of calorie restriction, and regulating longevity in lower organisms. Given the worldwide increase in age-related metabolic diseases the beneficial effects of resveratrol on metabolism and healthy aging in humans are currently a topic of intense investigation (reviewed by Prof. Johan Auwerx(Laboratory of Integrative Systems Physiology) in collaboration with researchers from The Netherlands).