There is inevitably a lag of a fraction of a second while the device loads a new preset. This is usually not very noticeable, but it is there. There is a more noticeable lag when connected via usb to your computer and running the editor. If you are connected when noticing this, just disconnect.

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Life is what happens to you while you're busy making other plans..... John Lennon

not much to do about it besides timing your changes live.....its really almost non-noticeable unless you're playing on your own.

The amount of effects/what they are can affect the changeover time as well...its takes longer to load a clean tone with 7 effects that a dirt tone with just a gate and a boost, so for live think about less DSP intensive effects where you can, as well.

Not to be disrespectful to the above posters, but Idisagree. The gap is most definitely noticeable - even in a band setting. There is nothing you can do about it. You have to work around it. I'm at the point where I try not to use ABCD patch switches anymore. Only 1-2-3-4-5-6-7-8 FX switches. It works well but limits your sounds to only 1 amp per song, unless you setup a dual-amp configuration in which case you're limited in how many effects you can add in. Removing ABCD patch switches also complicates turning on-off multiple FX with one stomp. So you have to pick which limitation you're willing to work around.