Databases

Neighborhood

Groups of genes that are frequently observed in each other's genomic neighborhood.

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Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:query proteins and first shell of interactors

white nodes:second shell of interactors

Node Content

empty nodes:proteins of unknown 3D structure

filled nodes:some 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

EFNCRP00000008042

Putative uncharacterized protein (330 aa)

Predicted Functional Partners:

EFNCRP00000006748

Methionine aminopeptidase (377 aa)

0.880

EFNCRP00000008011

Putative uncharacterized protein (396 aa)

0.664

EFNCRP00000008023

Predicted protein (222 aa)

0.597

B18D24.190

Putative uncharacterized protein (386 aa)

0.501

EFNCRP00000003758

Methionine aminopeptidase; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val) (481 aa)

a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1

node2

node1 accession

node2 accession

node1 annotation

node2 annotation

score

B18D24.190

EFNCRP00000000430

EFNCRP00000003373

EFNCRP00000000430

Putative uncharacterized protein

Related to 442K curved dna-binding protein

0.466

B18D24.190

EFNCRP00000003758

EFNCRP00000003373

EFNCRP00000003758

Putative uncharacterized protein

Methionine aminopeptidase; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val)

0.467

B18D24.190

EFNCRP00000006748

EFNCRP00000003373

EFNCRP00000006748

Putative uncharacterized protein

Methionine aminopeptidase

0.776

B18D24.190

EFNCRP00000008042

EFNCRP00000003373

EFNCRP00000008042

Putative uncharacterized protein

Putative uncharacterized protein

0.501

EFNCRP00000000430

B18D24.190

EFNCRP00000000430

EFNCRP00000003373

Related to 442K curved dna-binding protein

Putative uncharacterized protein

0.466

EFNCRP00000000430

EFNCRP00000008042

EFNCRP00000000430

EFNCRP00000008042

Related to 442K curved dna-binding protein

Putative uncharacterized protein

0.466

EFNCRP00000003758

B18D24.190

EFNCRP00000003758

EFNCRP00000003373

Methionine aminopeptidase; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val)

Putative uncharacterized protein

0.467

EFNCRP00000003758

EFNCRP00000006748

EFNCRP00000003758

EFNCRP00000006748

Methionine aminopeptidase; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val)

Methionine aminopeptidase

0.942

EFNCRP00000003758

EFNCRP00000008042

EFNCRP00000003758

EFNCRP00000008042

Methionine aminopeptidase; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val)

Putative uncharacterized protein

0.467

EFNCRP00000006748

B18D24.190

EFNCRP00000006748

EFNCRP00000003373

Methionine aminopeptidase

Putative uncharacterized protein

0.776

EFNCRP00000006748

EFNCRP00000003758

EFNCRP00000006748

EFNCRP00000003758

Methionine aminopeptidase

Methionine aminopeptidase; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val)

0.942

EFNCRP00000006748

EFNCRP00000008042

EFNCRP00000006748

EFNCRP00000008042

Methionine aminopeptidase

Putative uncharacterized protein

0.880

EFNCRP00000008011

EFNCRP00000008023

EFNCRP00000008011

EFNCRP00000008023

Putative uncharacterized protein

Predicted protein

0.570

EFNCRP00000008011

EFNCRP00000008042

EFNCRP00000008011

EFNCRP00000008042

Putative uncharacterized protein

Putative uncharacterized protein

0.664

EFNCRP00000008023

EFNCRP00000008011

EFNCRP00000008023

EFNCRP00000008011

Predicted protein

Putative uncharacterized protein

0.570

EFNCRP00000008023

EFNCRP00000008042

EFNCRP00000008023

EFNCRP00000008042

Predicted protein

Putative uncharacterized protein

0.597

EFNCRP00000008042

B18D24.190

EFNCRP00000008042

EFNCRP00000003373

Putative uncharacterized protein

Putative uncharacterized protein

0.501

EFNCRP00000008042

EFNCRP00000000430

EFNCRP00000008042

EFNCRP00000000430

Putative uncharacterized protein

Related to 442K curved dna-binding protein

0.466

EFNCRP00000008042

EFNCRP00000003758

EFNCRP00000008042

EFNCRP00000003758

Putative uncharacterized protein

Methionine aminopeptidase; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val)

0.467

EFNCRP00000008042

EFNCRP00000006748

EFNCRP00000008042

EFNCRP00000006748

Putative uncharacterized protein

Methionine aminopeptidase

0.880

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Network Stats

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Functional enrichments in your networkNote: some enrichments may be expected here (why?)

Enrichment analysis is still ongoing, please wait ...

Statistical background

For the above enrichment analysis, the following statistical background is assumed: