I am using the Unicode version for the PC Version 2.1.1.6
I did not do anything special to connect. Executed the app, plugged the E-61 (the E_61 select box opens, and I select PC Suite), then the button 'Connect' becomes available on the app.
I did remove all traces of Previous Blackberry Desktop & Client prior to installing the Nokia version of the Desktop.
Also, the first time u execute the BB Desktop, it checks for your Ms Exchange account provisioning for BES service.