Once you have drawn your molecule with the geometry you want, you need to
set up the type of computation (or ``level of theory'') for the Q-Chem
module. First make sure that the title HyperChem Menus appears to the
left of Help in the menu bar. If you see QChem Menus, then
click it so that the title changes to HyperChem Menus. This will give
you access to the Q-Chem menus in the menu bar.
Now go to the Setup menu and select Choose Basis Set.
Click the button next to the basis set of your choice, or click Other
to get additional choices.
Then you need to select Apply Basis Set to
place your basis set on all the atoms in your molecule. When you apply the
basis, make sure either no atoms or all atoms are selected. Otherwise, the
basis will only be applied to the selected atoms. You should not change
anything under Options or Advanced Options.

Once the basis is applied,
select Q-Chem Exchange and Correlation under the Setup menu to
set up the correlation treatment. For Hartree-Fock and MP2 computations,
Exchange should be set to Hartree-Fock. For DFT computations,
you may select whichever Exchange setting you like, except for
Hartree-Fock exchange, which doesn't really make sense for DFT. The value
of the Correlation selection should be No correlation for your
Hartree-Fock computations (since HF doesn't include correlation by
definition). For MP2, select MP2, and for DFT select whichever
correlation option you like, except for No correlation, MP2,
or CIS(D). Note that for DFT methods, certain choices for Exchange will override the choice of Correlation. If you pick B3LYP
or B3PW91, this automatically selects your correlation treatment for you
(LYP or PW91, respectively). Additionally, if you choose EDF1 exchange, you
ought to select LYP(EDF1) correlation.