Francis urged technological and scientific innovators to not abandon "equality and social inclusion." He also had sharp words for politicians, saying their power came with increased responsibility, and urged for compassion toward the sick, migrants and prison inmates.

Pope Francis arrives for an audience with members of Entrepreneurs for Economy of Communion, at the Paul VI Hall, at the Vatican, Saturday, Feb. 4, 2017. (AP Photo/Andrew Medichini)

Pope Francis remains popular nationwide, even among non-Catholics. About 70 percent of the population views him favorably, according to a January Pew poll. That's up from 57 percent at the start of his papacy in 2013.