But it'sAnna Wintour's python Prada coat worn to London Fashion Week that takes the most abuse. "She looks like she got that at a consignment store where pimps drop their coats off," joked Giuliana Rancic.

So are the show's hosts ready to put this trend out of its misery?

Not at all.

"If it's done right, gotta have it," says Joan.

Will you slip on an exotic skin or think this trend never should have left the jungle? Weigh in below!