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Early introduction of lipids to parenterally-fed preterm infants

Premature babies who are not yet ready to digest and absorb full milk feeds are given lipids through a vein to improve their nutrition. The issue of how early the lipids should be introduced to be advantageous while causing no harm is a matter of debate. The review found that, while no side effects were reported, there was no statistically significant benefit of introducing lipids before five days of age. Long term effects of early introduction of lipids in premature babies have not been reported.

Authors' conclusions:

No statistically significant effects of 'early introduction' of lipids on short term nutritional or other clinical outcomes, either benefits or adverse effects, were demonstrated in the studies reviewed. Based on the currently available evidence, 'early' initiation of lipids (≤ 5 days after birth) can not be recommended for short term growth or to prevent morbidity and mortality in preterm infants.