Background: The rules of quantitative measures such as parathyroid hormone (PTH) levels in the first hours following total thyroidectomy have since been validated repeatedly. Such measures play an integral rule in identifying patients at significant risk for hypocalcaemia and have allowed for earlier supplementation of these patients with calcium with or without vitamin D.

Methods: A retrospective analysis was conducted of 40 consecutive patients with well differentiated thyroid cancer (WDTC) who underwent total thyroidectomy without central neck dissection (CND) as an initial surgery and no comorbidity at King Abdulaziz Medical City (National Guard hospital), between July 2011 and July 2012. A blood testing protocol was applied for all patients that measured serum calcium PTH at 6 hours postoperatively.

Results: Following total thyroidectomy, women were found to experience transient hypocalcaemia in 12.5% of cases (4/32), whereas no men cases encountered this postoperative complication (0/8). However, most probably due to small sample size, this difference was not statistically significant. PTH level was significantly associated with post thyroidectomy hypocalcaemia (43.7±39.3 versus 13.40±24.9 ng/L), P=0.014. Only negligible differences in the length of hospital stay were observed with and without post-thyroidectomy hypocalcaemia.

Conclusions: Using post-thyroidectomy PTH levels to predict hypocalcaemia has been confirmed in the current study. So, the use of PTH levels allows for early risk stratification of our patients and we feel this has resulted in better patient satisfaction.

Introduction

Hypocalcaemia frequently complicates patients who have undergone thyroid surgery, occurring in as many as 30% of patients (1).

Hypocalcemia is multifactorial and may be due primarily to parathyroid excision, devascularization, and gland impair, which may lead to transitory or permanent hypoparathyroidism (1-3). Accompanying process, for instance vitamin D insufficiency, calcitonin realizes, “hungry bone syndrome” definitely conduce to this state (2,4). Authors have analyzed simple, reliable and sensitive instruments that may predict postoperative hypocalcemia (2,5-10). Serial measures of parathyroid hormone (PTH) and blood serum-corrected calcium levels following surgery have since been verified and allowed for earlier supplementation with calcium and vitamin D (5-8). Furthermore, these predictors have also facilitated thyroid surgeons to carefully opt subjects who may warily undergo early discharge (11). Finally, hospital budget earnings have been accomplished (6,8).

In the current study, we evaluate the association between PTH level and postoperative hypocalcaemia among patients underwent total thyroidectomy.

Methods

This is an analytical study conducted on 40 total thyroidectomies at King Abdulaziz Medical City (National Guard Hospital), between July 2011 and July 2012. Formal approval by the hospital ethical commission was obtained for this audit.

Statistical analysis

SPSS software and student’s t-test were utilized for testing the difference in the means of continuous variables. Non-Parametric Mann-Whitney test was applied in case of abnormally distributed data. Fischer exact test was used to test for the rate of hypocalcaemia between males and females.

The study was approved by Institutional Ethics Committee Board of King Abdulaziz Medical City (National Guard Hospital) (n. 2011/03) and written informed consent was obtained from all patients.

Results

As shown in Figure 1, following total thyroidectomy, 12.5% (4/32) women experienced transient hypocalcemia, on the contrary no men developed this morbidity. However, most probably due to small sample size, this difference was not statistically significant.

Mean postoperative serum calcium equable as follows: 2.26±0.11 mmol/L in men and 2.20±0.12 mmol/L in female while the mean PTH levels were as follows: 42.6±26.5 ng/L in men and 39.2±41.7 ng/L in female. The variance was non-significant (Table 1).

Table 1 Comparison between post-operative laboratory values according to gender Full table

There is a positive concordance midmost the serum calcium and PTH levels postoperatively (r=0.42. P=0.007).

Minor asymmetry in gland volume and dominant nodule size were found between genders. Furthermore, negligible differences in the length of hospital stay were observed with and without post-thyroidectomy hypocalcaemia.

Discussion

There has been a considerable effort in recent years in identifying simple, reliable and sensitive tools that may anticipate the risk for postoperative hypocalcemia (2,3,5,7,9-12).

Sands et al., 2011 reported a higher percentage of post-thyroidectomy hypocalcemia within female (13). We failed to confirm such fact most probably due to relatively small sample size of the current survey. Although Sands’ analysis indicate that gender divergence is an distinct risk factor for developing hypocalcemia, the specific apparatus can only be assumed and may be associated to the effects of peculiar femininity steroids on the PTH metabolism.

Several researches have been realized on the utility of PTH to foresee hypocalcemia after total thyroidectomy using hemi-thyroidectomy procedure as control group (14-16). Grodski and Serpell evaluated 24 studies where the blood serum calcium determinations were tested as an internal dominate (17). There was critical disparity in study protocol among all papers considered by the Authors (17). Quick PTH was adopt in most studies and standard PTH was apply in other group. The timing of hormone sampling differs from trial to trial: in some analysis the sample was extract directly after thyroid gland excision and the authors tempt to use this early information to decide for parathyroid auto transplantation. Authors concluded that when a 75–80% PTH decline is experienced, auto transplant is advised. Other protocols used serial measurement taken just after skin closure, at 5, 10, 20 min to 1, 2, 4, up to 24 and 48 h.

Heterogeneity was found also in the method the experiments were computed. Some Authors identified an absolute cut-off PTH level to separate cases into normocalcemia and hypocalcemia subjects. Rather, others validated the percentage of PTH decline to predict this morbidity.

Most studies limited the evaluation to patients undergoing total or completion thyroidectomy. Some series included patients undergoing subtotal gland resection and hemithyroidectomy.

With regard to indication for surgery, most Authors except Graves’ disease and concurrent central neck dissection (CND) for cancer.

Despite above mentioned differences, there is a general agreement of conclusions with a robust affinity of postoperative PTH with post-thyroidectomy hypocalcemia development. Our study, although included relatively small size, confirmed the aforementioned finding.

Payne et al. tested PTH levels at 6, 12, and 20 h after their surgery: merging PTH and serum calcium measurement at 6 h would fairly establish subjects not at risk for hypocalcemia (18-22). Such arrangement was 100% specific, identified 68% of normocalcemic patients enduring for secure early discharge, determining a reduced hospital stay and budget. Lombardi et al. similarly found that PTH at 4–6 h to be a precise predictor of hypocalcemia (23,24).

Other Authors, nonetheless, suggested discontinuing the use of postoperative PTH for predicting hypocalcemia. Ghaheri et al. tested PTH just after thyroid procedure and discovered that low PTH levels corresponded with postoperative hypocalcemia but could not anticipate it. In this study of 500 consecutive total thyroidectomies, 38% developed hypocalcemia, found normal PTH levels 4 h postoperative in 70 hypocalcemic patients, 11 of whom were symptomatic (22). The Authors posted that PTH alone couldn’t precisely anticipate clinically relevant postoperative hypocalcemia.

Del Rio et al. reviewed 1,000 total thyroidectomies and analyzed the accuracy of a 24-h PTH measurement in predicting hypocalcemia (25). Two hundred and fifty-three subjects presented with hypocalcemia of which 152 evidenced at 24 h. 101 patients evolved in late (>24 h postoperative) hypocalcemia, 49 of these had low PTH levels at 24 h. Del Rio et al. assured that PTH determination at 24 h may not be prognostic (25).

In summary, PTH absolute levels and percentage decline test properly anticipate the risk of hypocalcemia although lack of 100% accuracy. Grave hypocalcemia is improbable in the context of a regular PTH level. Accordingly, PTH can be tested discreetly to expedite early and safe discharge. PTH levels can be used to assign prime calcium and/or vitamin D supplements treatment to prevent the frequency and grade of hypocalcemia morbidity.

Acknowledgements

Deep appreciation to Prof. Dionigi for his support, corrections, guidance and manuscript revision.

Footnote

Conflicts of Interest: The authors have no conflicts of interest to declare.