We noted you are experiencing viewing problems

Check with your IT department that JWPlatform, JWPlayer and Amazon AWS & CloudFront
are not being blocked by your network.
The relevant domains are *.jwplatform.com,
*.jwpsrv.com, *.jwpcdn.com,
jwpltx.com, jwpsrv.a.ssl.fastly.net,
*.amazonaws.com and *.cloudfront.net.
The relevant ports are 80 and 443.

Share This Lecture

Email

Social

Permalink

You are viewing a talk that is a part of one of our comprehensive courses. Additional learning material: case studies, projects, workshops and recommended reading; multiple choice questions and suggested exam questions with model answers are available on application.
Learn more

Transcript

Choose Transcript Language:

0:00

Hello. My name is Tom Evans.I am a physician and the chief
executive officer of Aeras,a nonprofit biotechnology
organization thatis dedicated to
developing tuberculosisvaccines for the developing
world and all of the world.And I'd like to talk to
you today about wherewe are with TB vaccines,
noting that it's May of 2015.And this will be a
fast-moving field.

0:22

To start with, Mycobacterium
tuberculosis is the bacterial causeof this disease.It's important to realize
that this bacteriumhas co-evolved with man
sometime over the last 10,000to 70,000 years.There is still some controversy.And it's very unique in that it
is covered with these waxy mycolicacids and glycolipid
structures that make itvery different from
some other bacteria.They give it a protective coating.And they are part
of its pathogenesis.

0:48

Now, tuberculosis, why do
a vaccine for tuberculosis?Tuberculosis has been
mother nature's number onekiller over the past two centuries.Over the past two centuries,
a billion people,that was with a B, have
died from tuberculosis.Last year, tuberculosis
was tied with HIVas the leading cause of infectious
disease death in the world.A person dies from
tuberculosis every 21 seconds.There are 1.5 million deaths
per year, somewhere between 9and 10 million new cases per year.And this is an
epidemic that continuesunabated throughout the world.