Thursday, July 11, 2013

The You in Me

“According
to traditional thinking, the placenta acts as a barrier between a mother and a
child in the womb, preventing an exchange of cells between them. But
recent research has revealed that the placenta is more porous than previously
believed, says Kirby Johnson, a biologist at Tufts University. ‘Now we
know a mother and her baby have to be linked. Cell-based
communication is essential for a healthy pregnancy.’

“Overall,
the placenta allows for a lot of two-way traffic, with fetal cells stealing
into Mom, and maternal cells slipping into Child. (Even tumor cells can
cross over, and there are a few well-documented cases of mothers giving cancer
to fetuses.) After cells cross over, some get rounded up and killed by
the new host’s immune system. Many, however, take root in the other body,
burrowing into the heart, liver, kidneys, spleen, skin, pancreas, gallbladder,
and intestines, among other places. Most of these organs house tens to
hundreds of interlopers per million normal cells, but the lungs can tolerate
thousands of foreign cells per million. Fetal cells do an especially good
job of colonizing Mom’s body since they often have the power, much like stem
cells, to turn into multiple types of tissue, depending on where they find
themselves.

“At
first, researchers assumed that microchimeric transplants would harm the
recipient. Most scientists who study microchimerism also study autoimmune
diseases, which occur in women three times more often than in men.
Scientists have reasoned that perhaps a mother’s immune system, in trying to
exterminate fetal cells inside her, inadvertently causes collateral damage to
her own tissue. Or perhaps the fetal cells, surrounded by foreign tissue,
rebel and attack the mother. Studies have indeed linked high levels of
microchimeric cells to some forms of lupus, cirrhosis, and thyroid
disease. Twin studies have also found higher levels of microchimerism in females
with multiple sclerosis….

“On a
more general level, given all the two-way cellular traffic, ‘the dogma of every
cell in our body being genetically identical has to be revised,’ (says Gerald
Udolph, a biologist at the Institute of Medical Biology in Singapore).“