A systematic literature review to inform the task force on “Treating spondyloarthritis, including ankylosing spondylitis and psoriatic arthritis, to target: 2017 update of recommendations by an international task force”

The systematic literature review was performed by Monika Schöls

Дополнительная таблица S1. Термины поиска в базе данныхMedline

(((((((spondylarthr*[Title]) OR spondyloarthr*[Title]) OR ankylosing[Title]) OR (axial[Title] AND SpA[Title])) OR (radiologic*[Title] AND SpA[Title])) OR (radiographic*[Title] AND SpA[Title])) OR Bechterew[Title]) OR (psoria*[Title] AND arthr*[Title])

slight increase in the proportion of with erosive disease for both TX arms (30.7%); JSN remained similar to that observed at baseline (85.8%). Median total modified Sharp-van der Heijde scores (mvdHS) at week 48 remained similar across TX arms (8.0 TC vs 6.0 SC). No evidence of a difference in the change in mvdHS scores btw. TX arms at week 48 (p=0·9779), with median change of zero in both arms.

slight increase in the proportion of pts with erosive disease for both TX arms (30.7%); JSN similar to baseline (85.8%). Median total mvdHS scores at w 48 remained similar across TX arms (8.0 TC vs 6.0 SC). No evidence of a difference in the change in mvdHS scores btw. TX arms at w 48 (p=0·9779); median change of zero in both arms.

1-point increase in ASDAS resulted in an increase of 18.5%, 16.9%, 9.6% in WPL, presenteeism and absenteeism, respectively.

Machado 2011(15)

ASDAS

BASDAI

Function: BASFI

HRQoL: SF-36 PCS, MCS

SF-36 PCS associated with physical function and disease activity (adjusted R(2) (adjR(2))=0.39-0.40). SF-36 MCS independently associated with physical function (adjR(2)=0.07). Physical function was independently associated with measures of spinal mobility and disease activity (adjR(2)=0.39-0.45). Spinal mobility was hierarchically shown to be an intermediate variable btw. structural damage and physical function, while physical function was shown to be intermediate btw. spinal mobility and the physical component of SF-36. HRQoL is determined by physical function and disease activity, physical function is determined by spinal mobility and disease activity, and spinal mobility is determined by structural damage and inflammation of the spine.

van Lunteren 2016(16)

ASDAS

QoL: SF-36 PCS

decrease in disease activity assoc. with clear improvement in QoL: decrease of one unit of ASDAS BL to 1y resulted in improvement in PCS of 9.2 (SE 1.6) over 1y. Fulfilment of the clinical or imaging arm (p=0.036) and gender (p=0.082) were effect modifiers in the model for PCS.

Ramiro 2014(17)

ASDAS

BASDAI

CRP

Radio: mSASSS

models with ASDAS fitted the data better than models with BASDAI, CRP or BASDAI+CRP. An increase of one ASDAS unit led to an increase of 0.72 mSASSS units/2 yrs.A ‘very high disease activity’ (ASDAS >3.5) compared with ‘inactive disease’ (ASDAS <1.3) resulted in an additional 2-y. progression of 2.31 mSASSS units. The effect of ASDAS on mSASSS was higher in males vs. females (0.98 vs -0.06 mSASSS units per ASDAS unit) and in pts. with <18yrs. vs ≥18yrs. symptom duration (0.84 vs 0.16 mSASSS units per ASDAS unit). CONCL.: 1st study showing that disease activity contributes longitudinally to radiographic progression in the spine in AS. effect more pronounced in men and in earlier disease.

trend for positive association btw. single components of the ASDAS (BASDAI, CRP and PtGA) and mSASSS worsening by two points and stat sign. assoc. btw. syndesmophyte formation/progression and CRP (OR 1.07; 1.01–1.13) as well as PtGA (OR 1.30; 1.01–1.69)