The neighbourhood of Kodambakkam has a history going back to about 2,000 years. During the period of the Pallavas and the Later Cholas, the western part of Kodambakkam formed a portion of the historically important temple town of Vadapalani. One of the oldest temples in Kodambakkam is the Bharthukesavar temple which is over 500 years old.

Present-day Kodambakkam originated in the 17th and 18th centuries AD, when it supposedly served as source for the horses of the stable of the Nawab of the Carnatic. It is believed that the name "Kodambakkam" itself might have been derived from the Urdu word Ghoda Bagh meaning "garden of horses". Another version says that "Kodambakkam" derives its name from "Karkodagan Pakkam". Karkodagan is the name of a famous snake in Hindu mythology. It is said that the snake worshiped Lord Shiva here. There is still a temple for Lord Shiva by the name Vengeeshwarar in Kodambakkam. Several sculptures and images of the snake Karkodagan can be seen in the temple, even today.

Under the British, Kodambakkam was administered as a municipality in Chingleput district till the draining of the Long Tank in 1921, when Kodambakkam was incorporated into the Madras city and formed the Kodambakkam-Saligrammam-Puliyur district of Greater Madras along with other localities to the west of the now extinct Long Tank, with a population of 497 people in 1939. Kodambakkam also played an important role in the Anti-Hindi agitations of 1938 when Maraimalai Adigal presided over a conference denouncing the imposition of Hindi in the Madras Presidency on June 3, 1938.[1]

The first movie studio was established by Avichi Meiyappa Chettiar in 1948. Since then, a number of other movie studios have been established, notable among them being L. V. Prasad Studios and Vijaya Vauhini studios. Liberty theater which is the oldest theater among others theaters in chennai, in those days all film stars were used to see film in this theater. But now that theater been demolished because of no maintenance.

Residences of many film and television stars are located in and around Kodambakkam due to proximity to the movie studios. A film directors' colony situated in Kodambakkam is the home of many Tamil film directors and producers.