The protein encoded by CHL1 is a member of the L1 gene family of neural cell adhesion molecules. Additionally we are shipping CHL1 Kits (14) and CHL1 Proteins (12) and many more products for this protein.

These results provide strong support for a 'two-hit' (genes x environment) effect on latent inhibition in CHL1-deficient mice, and identify CHL1-deficient mice as a model of schizophrenia-like learning and attention impairments.

Findings indicate that disrupted-in-schizophrenia 1 (DISC1 (show DISC1 Antibodies)) and close homolog of L1 may engage in physical and functional interaction in neural development, supporting the notion that DISC1 (show DISC1 Antibodies) regulates neurite outgrowth with a receptor belonging to the neural cell adhesion molecules.

CHL1 is a novel intrinsic factor (show GIF Antibodies) that is involved in carotid body function and in the ventilatory response to acute hypoxia.

CHL1 endocytosis are required for CHL1-dependent neurite outgrowth.

CHL1 Antigen Profile

Protein Summary

The protein encoded by this gene is a member of the L1 gene family of neural cell adhesion molecules. It is a neural recognition molecule that may be involved in signal transduction pathways. The deletion of one copy of this gene may be responsible for mental defects in patients with 3p- syndrome. This protein may also play a role in the growth of certain cancers. Alternate splicing results in both coding and non-coding variants.