Graphical Abstract:

Abstract:

Self-assembled peptides and specifically small peptide based nanostructures
have been the focus of research in past decade due to their potential biological applications.
In this study, we prepared a protected peptide, Boc-Pro-Phe-Gly-OMe, which
self-assembled in aqueous solutions leading to the formation of nanostructures and
ability to act as a drug carrier. Dynamic light scattering (DLS) measurements showed
nanostructures with average size of 119.6 nm containing hydrophobic core, wherein hydrophobic drugs, viz, eosin, aspirin
and curcumin, were successfully encapsulated. These encapsulated nanostructures, were further stabilized with Vitamin
E–TPGS. In-vitro drug release studies revealed the release of drugs in controlled fashion from the nanostructures. The results
advocate the potential of the proposed peptide nanostructures as controlled drug delivery systems and could be used
in other biomedical applications.

Abstract:Self-assembled peptides and specifically small peptide based nanostructures
have been the focus of research in past decade due to their potential biological applications.
In this study, we prepared a protected peptide, Boc-Pro-Phe-Gly-OMe, which
self-assembled in aqueous solutions leading to the formation of nanostructures and
ability to act as a drug carrier. Dynamic light scattering (DLS) measurements showed
nanostructures with average size of 119.6 nm containing hydrophobic core, wherein hydrophobic drugs, viz, eosin, aspirin
and curcumin, were successfully encapsulated. These encapsulated nanostructures, were further stabilized with Vitamin
E–TPGS. In-vitro drug release studies revealed the release of drugs in controlled fashion from the nanostructures. The results
advocate the potential of the proposed peptide nanostructures as controlled drug delivery systems and could be used
in other biomedical applications.