I have long held an opinion, almost amounting to conviction, in common I believe with many other lovers of natural knowledge, that the various forms under which the forces of matter are made manifest have one common origin; or, in other words, are so directly related and mutually dependent, that they are convertible, as it were, one into another, and possess equivalents of power in their action.

Paper read to the Royal Institution (20 Nov 1845). 'On the Magnetization of Light and the Illumination of Magnetic Lines of Force', Series 19. In Experimental Researches in Electricity (1855), Vol. 3, 1. Reprinted from Philosophical Transactions (1846), 1.

In our day grand generalizations have been reached. The theory of the origin of species is but one of them. Another, of still wider grasp and more radical significance, is the doctrine of the Conservation of Energy, the ultimate philosophical issues of which are as yet but dimly seem-that doctrine which 'binds nature fast in fate' to an extent not hitherto recognized, exacting from every antecedent its equivalent consequent, and bringing vital as well as physical phenomena under the dominion of that law of causal connexion which, so far as the human understanding has yet pierced, asserts itself everywhere in nature.

'Address Delivered Before The British Association Assembled at Belfast', (19 Aug 1874). Fragments of Science for Unscientific People: A Series of Detached Essays, Lectures, and Reviews (1892), Vol. 2, 1801.

In the vestibule of the Manchester Town Hall are placed two life-sized marble statues facing each other. One of these is that of John Dalton ... the other that of James Prescott Joule. ... Thus the honour is done to Manchester's two greatest sons—to Dalton, the founder of modern Chemistry and of the atomic theory, and the laws of chemical-combining proportions; to Joule, the founder of modern physics and the discoverer of the Law of Conservation of Energy.One gave to the world the final proof ... that in every kind of chemical change no loss of matter occurs; the other proved that in all the varied modes of physical change, no loss of energy takes place.

It is the destiny of wine to be drunk, and it is the destiny of glucose to be oxidized. But it was not oxidized immediately: its drinker kept it in his liver for more than a week, well curled up and tranquil, as a reserve aliment for a sudden effort; an effort that he was forced to make the following Sunday, pursuing a bolting horse. Farewell to the hexagonal structure: in the space of a few instants the skein was unwound and became glucose again, and this was dragged by the bloodstream all the way to a minute muscle fiber in the thigh, and here brutally split into two molecules of lactic acid, the grim harbinger of fatigue: only later, some minutes after, the panting of the lungs was able to supply the oxygen necessary to quietly oxidize the latter. So a new molecule of carbon dioxide returned to the atmosphere, and a parcel of the energy that the sun had handed to the vine-shoot passed from the state of chemical energy to that of mechanical energy, and thereafter settled down in the slothful condition of heat, warming up imperceptibly the air moved by the running and the blood of the runner. 'Such is life,' although rarely is it described in this manner: an inserting itself, a drawing off to its advantage, a parasitizing of the downward course of energy, from its noble solar form to the degraded one of low-temperature heat. In this downward course, which leads to equilibrium and thus death, life draws a bend and nests in it.

The law of conservation rigidly excludes both creation and annihilation. Waves may change to ripples, and ripples to waves,—magnitude may be substituted for number, and number for magnitude,—asteroids may aggregate to suns, suns may resolve themselves into florae and faunae, and florae and faunae melt in air,—the flux of power is eternally the same. It rolls in music through the ages, and all terrestrial energy,—the manifestations of life, as well as the display of phenomena, are but the modulations of its rhythm.

The most convincing proof of the conversion of heat into living force [vis viva] has been derived from my experiments with the electro-magnetic engine, a machine composed of magnets and bars of iron set in motion by an electrical battery. I have proved by actual experiment that, in exact proportion to the force with which this machine works, heat is abstracted from the electrical battery. You see, therefore, that living force may be converted into heat, and that heat may be converted into living force, or its equivalent attraction through space.

The total quantity of all the forces capable of work in the whole universe remains eternal and unchanged throughout all their changes. All change in nature amounts to this, that force can change its form and locality, without its quantity being changed. The universe possesses, once for all, a store of force which is not altered by any change of phenomena, can neither be increased nor diminished, and which maintains any change which takes place on it.

There is deposited in them [plants] an enormous quantity of potential energy [Spannkräfte], whose equivilent is provided to us as heat in the burning of plant substances. So far as we know at present, the only living energy [lebendige Kraft] absorbed during plant growth are the chemical rays of sunlight... Animals take up oxygen and complex oxidizable compounds made by plants, release largely as combustion products carbonic acid and water, partly as simpler reduced compounds, thus using a certain amount of chemical potential energy to produce heat and mechanical forces. Since the latter represent a relatively small amount of work in relation to the quantity of heat, the question of the conservation of energy reduces itself roughly to whether the combustion and transformation of the nutritional components yields the same amount of heat released by animals.

There is no force inherent in living matter, no vital force independent of and differing from the cosmic forces; the energy which living matter gives off is counterbalanced by the energy which it receives.

To Nature nothing can be added; from Nature nothing can be taken away; the sum of her energies is constant, and the utmost man can do in the pursuit of physical truth, or in the applications of physical knowledge, is to shift the constituents of the never-varying total. The law of conservation rigidly excludes both creation and annihilation. Waves may change to ripples, and ripples to waves; magnitude may be substituted for number, and number for magnitude; asteroids may aggregate to suns, suns may resolve themselves into florae and faunae, and floras and faunas melt in air: the flux of power is eternally the same. It rolls in music through the ages, and all terrestrial energy—the manifestations of life as well as the display of phenomena—are but the modulations of its rhythm.

We have one great guiding principle which, like the pillar of cloud by day, and the pillar of fire by night, will conduct us, as Moses and the Israelites were once conducted, to an eminence from which we can survey the promised scientific future. That principle is the conservation of energy.

[Helmholtz] is not a philosopher in the exclusive sense, as Kant, Hegel, Mansel are philosophers, but one who prosecutes physics and physiology, and acquires therein not only skill in developing any desideratum, but wisdom to know what are the desiderata, e.g., he was one of the first, and is one of the most active, preachers of the doctrine that since all kinds of energy are convertible, the first aim of science at this time. should be to ascertain in what way particular forms of energy can be converted into each other, and what are the equivalent quantities of the two forms of energy. Letter to Lewis Campbell (21 Apr 1862).

[Ignorance] of the principle of conservation of energy … does not prevent inventors without background from continually putting forward perpetual motion machines… Also, such persons undoubtedly have their exact counterparts in the fields of art, finance, education, and all other departments of human activity… persons who are unwilling to take the time and to make the effort required to find what the known facts are before they become the champions of unsupported opinions—people who take sides first and look up facts afterward when the tendency to distort the facts to conform to the opinions has become well-nigh irresistible.

In science it often happens that scientists say, 'You know that's a really good argument; my position is mistaken,' and then they would actually change their minds and you never hear that old view from them again. They really do it. It doesn't happen as often as it should, because scientists are human and change is sometimes painful. But it happens every day. I cannot recall the last time something like that happened in politics or religion.
(1987) -- Carl Sagan