Insulin activity of the blood, the action on it of various loads and the effect of blood serum on the effect of insulin relative to fatty tissue in chronic pancreatitis

Abstract: In patients with chronic pancreatitis a decrease in insulin activity of blood was observed. The activity was tested using preparations of diaphragm and epididymal fat of rats. Reaction of the insulin activity of blood, after loading with glucose, secretine and pancreosimine, was also decreased. The phenomenon was probably important for development of decreased tolerance to carbohydrates, which was observed in patients with chronic pancreatitis. In blood serum of the patients no effect of inhibition of the insulin activity could be observed by means of influence of insulin on lipolysis in epididymal rat adipose tissue. The data obtained suggest that in chronic pancreatitis the leading role in development of carbohydrate metabolism impairements belonged to the quantitative insufficiency of insulin, but not to the qualitative alterations in blood serum, where the ability to inhibite the insulin activity appeared.

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Reference: Geller L.I., Kazimirchik A.P., Bulgakova O.S., Amatniak A.G., Bystrovskiĭ V.F., Insulin activity of the blood, the action on it of various loads and the effect of blood serum on the effect of insulin relative to fatty tissue in chronic pancreatitis, Voprosy meditsinskoi khimii, 1975, vol: 21(1), 85-87.