Genetic studies in several model organisms have helped to unravel a multitude of physiological functions associated with cullin proteins and their respective CRLs. (biomedcentral.com)

The Epstein-Barr virus protein BPLF1, is targeted to cullin-RING ubiquitin ligases (CRLs) via the interaction of the conserved helix-2 with helix-23 of cullins, at a site involved in electrostatic interaction with CAND1. (nih.gov)

Study shows that Cand1 can unambiguously stimulate SCF activity in vitro by enabling an F box protein-Skp1 complex to access Cul1 that was previously occupied by a different F box protein-Skp1 complex, and that Cand1 promotes assembly in vivo of new F box proteins with pre-existing Cul1 molecules. (nih.gov)

Although CUL7 and PARC are present only in chordates, other members of the cullin protein family are found in Drosophila melanogaster , Caenorhabditis elegans, Arabidopsis thaliana and yeast. (biomedcentral.com)