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Molecular Biology, Biochemistry, Genetics, and Animal Models

Posted by: National Institutes of Health (NIH)

Posted date: 2018-Dec-20

Location: USA

The National Institute on Aging, a major research component of the National Institutes of Health (NIH) and the Department of Health and Human Services (DHHS) is recruiting one post-doctoral fellow to join the Laboratory of Genetics and Genomics, Intramural Research Program (IRP), with a background in any of the following areas: RNA biology, molecular biology, genomics, epigenetics, mouse models, and transcription. The main project aimsto better understand the factors that play a role in the stability of p16INK4A and ARF mRNA and their effects in cancer and aging. p16INK4A is highly dynamic, being largely undetectable in healthy young cells and tissues, but, in contrast, it is robustly expressed in many tissues and cells with aging. The contribution of mRNA turnover to cellular senescence is becoming increasingly apparent (PNAS, 2019, Aging Cell, 2018). In this project, studying the relationship between mRNA accumulation, transcriptional activity and mRNA stability of p16 and roles of RBP in p16mRNA expression during cellular senescence.

Successful applicants will possess a PhD degree in biochemistry, molecular biology, genetics or a related field, with no more than five years of postdoctoral research experience. Salary is commensurate with research experience and accomplishment.

This position is located in Bethesda, MD, a city with a stimulating scientific and cultural environment

The NIH is dedicated to building a diverse community in its training and employment programs.