Did someone (maybe me?) post an article a few months ago about a study on testosterone supplementation and exercise in elderly men? As I recall, it involved 4 study groups; test only, resistance exercise only, text plus exercise, and control with neither. The subjects were all older men. I'm interested in seeing it again, particularly in regard to the side effects (which, as I recall, were minimal).

_________________Our greatest fear should not be of failure, but of succeeding at things in life that don't really matter.--Francis Chan

Not what you're looking for but I happened to see this one yesterday and you might find interesting.

"A decline in testosterone levels as men grow older is likely the result—not the cause—of deteriorating general health, say Australian scientists, whose new study finds that age, in itself, has no effect on testosterone level in healthy older men."

_________________Stu Ward_________________Let thy food be thy medicine, and thy medicine be thy food.~HippocratesStrength is the adaptation that leads to all other adaptations that you really care about - Charles Staley_________________Thanks TimD

Growing old doesn't slow you down, it's slowing down that makes you old.

Ha! Keep telling yourself that Pops

Thanks, punk.

_________________Stu Ward_________________Let thy food be thy medicine, and thy medicine be thy food.~HippocratesStrength is the adaptation that leads to all other adaptations that you really care about - Charles Staley_________________Thanks TimD

Nope. The article that I think I remember (inserting aging joke of choice here) used relatively high-dose testosterone given intramuscularly once a week. That's why the low rate of adverse effects was interesting.

_________________Our greatest fear should not be of failure, but of succeeding at things in life that don't really matter.--Francis Chan

Good find Mark. Growing old doesn't slow you down, it's slowing down that makes you old.

Glad to be of service. On a sidenote your summing up reminded of something Berardi (IIRC) wrote about the metabolic slowdown that is supposedly responsible for turning 30 and 40 yos in fat slabs. It was something like in people who don't train metabolism slows down like 10+% every decade, whereas in people who stay active it was something like 0.5% per decade. Sadly, I have no time to look it up now.

_________________I don't know where the blind could lead the sightlessbut I'd still like to witness

Good find Mark. Growing old doesn't slow you down, it's slowing down that makes you old.

Great quote! Is this original with you, or are you quoting some famous and wise person?

I'm sure I read that somewhere but I don't know where.

_________________Stu Ward_________________Let thy food be thy medicine, and thy medicine be thy food.~HippocratesStrength is the adaptation that leads to all other adaptations that you really care about - Charles Staley_________________Thanks TimD

Nope. The article that I think I remember (inserting aging joke of choice here) used relatively high-dose testosterone given intramuscularly once a week. That's why the low rate of adverse effects was interesting.

_________________Stu Ward_________________Let thy food be thy medicine, and thy medicine be thy food.~HippocratesStrength is the adaptation that leads to all other adaptations that you really care about - Charles Staley_________________Thanks TimD

In fact, according to research, individuals who—through exercise and smart eating—maintain their lean mass (muscle, bone, and other non-fat tissue) as they age experience only a 0.36 percent drop in metabolism per decade compared to the 5 to 7 percent per decade drop that most adults experience.

Unfortunately there are no references to the actual studies.

_________________I don't know where the blind could lead the sightlessbut I'd still like to witness

Andy and I have posted before about this and it's clear that most of the benefit comes from attempting to build power, strength and muscle, no matter what your age. The details of an optimal exercise protocol may still be debatable but doing something, anything, is critical.

_________________Stu Ward_________________Let thy food be thy medicine, and thy medicine be thy food.~HippocratesStrength is the adaptation that leads to all other adaptations that you really care about - Charles Staley_________________Thanks TimD

_________________Stu Ward_________________Let thy food be thy medicine, and thy medicine be thy food.~HippocratesStrength is the adaptation that leads to all other adaptations that you really care about - Charles Staley_________________Thanks TimD

I don't think anyone says that they are side-effect free. The emphasis here is on "potentially". The potential effects are known. The important question is how often they occur in actual usage, and how severe are they when they occur. It's assumed that the potential for significant harm would increase with longer periods of use, but again, this needs to be determined by actual experience.

Quote:

"The absence of systemic toxicity during testosterone treatment was consistent with the results of studies of the contraceptive efficacy of that hormone."

This sentence has a reference to a study from 1988 on high-dose testosterone used over a period of 6 months in a small number of men as a male contraceptive. I can't access the full text of 1988 articles, and the abstract doesn't say what the actual dose was. But the authors of the Bahsin article imply that there were no significant SEs in that study.

Again, it would be nice to see large, longer duration studies of adverse effects.Here is a meta-analysis of studies of benefits and risks of long-term testosterone replacement. All of these involved attempts to bring test levels up to normal, not the supra normal levels of the Bahsin study.

_________________Our greatest fear should not be of failure, but of succeeding at things in life that don't really matter.--Francis Chan

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