Wise’s work has included pioneering miniature devices such as pressure sensors, thermal imagers, neural probes, and more. Among his accomplishments, Najafi initiated groundbreaking research on wireless interfaces that enabled implanted devices to deliver a signal to an external monitor.

In 1995, Wise, Khalil Najafi and Nader Najafi co-founded Integrated Sensing Systems, an Ypsilanti-based company whose products include a battery-less implantable sensor and companion handheld reader that monitors the condition of patients with congestive heart failure.

The center has also resulted in 12 start-up companies. A few examples are NeuroNexus Technologies, which makes probes used in neurological research; Enertia, which makes energy scavenging systems for energy-efficient homes; and Ambiq Micro, which produces advanced processors needed for ever-smaller devices.

Sixteen companies were formed from the larger microsystems program at U-M, of which 10 were founded by Najafi, Wise or their students.

To further capture the potential of microsystems and nanotechnology, the university recently expanded the Robert H. Lurie Nanofabrication Facility, directed by Wise. The center facilitates research across campus and forms one node, directed by Najafi, of the NSF National Nanotechnology Infrastructure Network.

The LNF now serves more than 400 users and two dozen companies, many of them start-ups in southeastern Michigan, and some billion-dollar companies whose access to the technology positions them to compete in entirely new areas.

Nancy Connell is the director of strategic communications at the University of Michigan. She can be reached by at nconnell@umich.edu.