Wls-mediated secretion of Wnt (show WNT2 ELISA Kits) ligands from the developing ventral body wall mesenchyme plays a critical role in fusion of the sternum and closure of the secondary body wall.

eletion of the Wls gene in odontoblasts appears to reduce canonical Wnt (show WNT2 ELISA Kits) activity, leading to inhibition of odontoblast maturation and root elongation.

The existence of spatial compartmentation in the rhombic lip and the interplay between Wls, Math1 (show ATOH1 ELISA Kits), and Pax6 (show PAX6 ELISA Kits) in the rhombic lip provides novel views of early cerebellar development.

Retromer dependent recycling of the Wnt secretion factor Wls is dispensable for stem cell maintenance in the mammalian intestinal epithelium

The loss of Wls in the ventral epithelium, which blocks the secretion of Wnt (show WNT2 ELISA Kits) proteins, resulted in dysgenesis of ventral musculature and genitourinary tract during embryonic development.

Zebrafish Wntless Homolog (Drosophila) (WLS) interaction partners

Homozygous wls mutants show a reduction in two cell populations that contribute to the presumptive dorsal habenulae.

The relatively ubiquitous expression of GPR177 suggests that this protein may serve to regulate Wnt (show WNT2 ELISA Kits) secretion in a variety of embryonic and adult tissue types.

WLS Antigen Profile

Antigen Summary

Regulates Wnt proteins sorting and secretion in a feedback regulatory mechanism. This reciprocal interaction plays a key role in the regulation of expression, subcellular location, binding and organelle-specific association of Wnt proteins. Plays also an important role in establishment of the anterior-posterior body axis formation during development (By similarity).