Interesting. I take Pristiq for my migraines and it seems to help but I've always thought mine were hormonal since they seem to be worse around that time of the month.Co-moderator: Ulcerative ColitisDiagnosed with Pancolitis, Laryngopharyngeal Reflux & Migraines. Battling Extreme Exhaustion.Currently: Asacol (2800mg) + 6mp (25mg) + Pristiq (50mg) + prilosec (40mg) +Canasa (1g PM) + cerazette