Category Archives: ctDNA

I love it. Professor Tony Seba, Stanford, 1 week ago. It means anyone who continues to invest in or support the fossil fuels hegemony will be fundamentally disappointed by the markets. And it serves them right. By efficiency, or momentum, … Continue reading →

Part 1 of this series introduced the idea of ctDNA and its use for detecting cancers or their resurgence, and proposed a scheme whereby relative concentrations of ctDNA at two or more sites after controlled disturbance might be used to … Continue reading →

Kalman filtering and smoothing; dynamic linear models

I have used dlm almost exclusively, except when extreme efficiency was required. Since Jouni Helske's KFAS was rewritten, though, I'm increasingly drawn to it, because the noise sources it supports are more diverse than dlm's. KFAS uses the notation and approaches of Durbin, Koopman, and Harvey.

``The real problem is that programmers have spent far too much time worrying about efficiency in the wrong places and at the wrong times; premature optimization is the root of all evil (or at least most of it) in programming.''Professor Donald Knuth, 1974