Project: influence of creatine supplementation on mechanical and biochemical properties of the striated muscle in an uremic animal model.

project duration

01-OCT-01 – 30-SEP-03

abstract

End stage renal desease is complicated by uremic myopathy. This is characterized by muscle weakness, fatigue, exhaustion upon inimal exercise. The underlying causes are multiple: anemia, hyperparathyroidism, metabloic acidosis, vit D deficiency, neuropathy and electrolyte abnormalities. This project investigates the value of creatine supplementation on biochemical and mechanical properties of the striated muscle in uremia.