The objective of this project is to develop novel treatments, using expression-targeted gene therapy and minicell technology, to replace current methodologies used in the clinic for the treatment of carcinomas, especially transitional cell...

In the reopening of fluid occluded airways, the pressure gradient due to the propagation of an air bubble causes extensive epithelial cell damage. The mechanism of cell necrosis and biotransport may be further understood by characterizing the flow...

In mice, the odontogenic potential shifts from the dental epithelium to the mesenchyme around E12.5. However, it is unknown if the odontogenic potential of E13.5 molar mesenchyme requires the specific spatial organization of the mesenchymal cells...

In 2005, 1.6 million Americans lived with a debilitating amputation and this figure is predicted to double by 2050. But the ability of a mammal to recapitulate a complex limb structure is not impossible. Evidence of children and mice re-growing...

The breath figure method is a versatile and facile approach of generating ordered micro and nanoporous structures in polymeric materials. When a polymer solution (dissolved in a high vapor pressure organic solvent) is evaporated out in the presence...

Exposure to endocrine disrupting compounds (EDCs) has been linked to cancer, sperm counts decline, premature puberty, and abnormal reproductive tract development. Often, these effects can include transgenerational effects, and can result from...

The effects of cobalt on male reproduction were evaluated in mice after acute and chronic cobalt treatment. The impact of acutely administered cobaltous chloride (200 $\mu$moles/kg, i.p., for 3 days) was assessed using the dominant lethal assay...

Currently, most contact lenses are made with a silicone hydrogel (Si-Hy) blend that provides softness for comfort as well as high oxygen permeability. Silicone hydrogel lenses have both hydrophilic and hydrophobic areas, and the natural...

Peptide growth factors mediate epithelial-mesenchytnal interactions during organogenesis. In vitro, the expression of Pigpen, a nuclear protein, was shown to correlate with growth factor-mediated changes in proliferation and differentiation in...