This study presents the inventory of pesticides and an assessment of water and sediments pollution in two agricultural areas of Mexico. Triazinic, fenoxychlorinated, and organo-chlorine pesticides were analyzed, including six persistent organic pollutants (POP). Although the use of atrazine is restricted and prohibited in various parts of the World, this herbicide is still being used in Mexico without restriction and our results show that this herbicide affects water quality in one of the agricultural areas. The concentrations of atrazine and one of its metabolites (desethylatrazine) in water samples exceeded the limit of 2 µg L-1 proposed by the World Health Organization for this herbicide in drinking water (WHO 2008) and the one of the European Community has satted at 0.1 µg L-1 for drinking water (European Parliament 1998). The metabolites of the pesticide DDT (DDD and DDE) exceeded the interim sediment quality guideline (ISQG) for freshwater sediments established by the Canadian Council of Environmental Ministers although concentrations do not exceed the probable effect level (PEL) (CCME 2003). Although the use of DDT in agriculture has been banned in Mexico (DOF 1991), the results show that the metabolites of this pesticide continue to appear in environmental samples due to its long half-life. Surveillance monitoring is proposed for the pesticides found in levels higher than established in limits and criteria.