Papers by Keyword: Cerebral Blood Flow

Abstract: The highlight of photoacosutic imaging (PAI) is a method that combines ultrasonic
resolution with high contrast due to light absorption. Photoacoustic signals carry the information of
the light absorption distribution of biological tissue, which is often related to its character of
structure, physiological and pathological changes because of different physiology conditions in
response to different light absorption coefficients. A non-invasive PAI system was developed and
successfully acquired in vivo images of mouse brain. Based on the intrinsic PA signals from the
brain, the vascular network and the detailed structures of the mouse cerebral cortex were clearly
visualized. The ability of PAI monitoring of cerebral hemodynamics was also demonstrated by
mapping of the mouse superficial cortex with and without drug stimulation. The extracted PA
signals intensity profiles obviously testified that the cerebral blood flow (CBF) in the mouse brain
was changed under the stimulation of acetazolamide (ACZ). The experimental results suggest that
PAI can provide non-invasive images of blood flow changes, and has the potential for brain
function detection.