Study

COSU30

GRCh38 · COSMIC v84

This section shows a general overview of information for the selected
study (COSU identifier) or publication (COSP identifier). Studies may
have been performed by the Sanger Institute Cancer Genome Project, or
imported from the ICGC/TCGA. You can see more information on the
help pages.

Study

Cancer cell lines kinase study

Study ID

COSU30

Description

Protein kinases are frequently mutated in human cancer and inhibitors of mutant protein kinases have proven to be effective anticancer drugs. In this study, the coding domains of the entire protein kinase gene family have been examined in a primary collection of tumours (6 malignant melanomas, 5 renal cell carcinomas, 4 lung small cell carcinomas, 3 head/neck squamous cell carcinomas, 2 bladder carcinomas, 1 pancreatic ductal carcinoma, 1 mesothelioma). 148 of the 518 kinase genes were mutated in at least one sample, producing a total of 207 mutations, the majority of which were missense events. No mutation clusters were observed. Four tumours had more than 10 mutations, with 2 showing a significant hypermutable phenotype, CP66-MEL with 41 mutations and MZ7-mel with a total of 70, the most highly mutated sample we have yet seen. Interestingly, no mutations were observed in TP53, in the MPv6 additions study.

AA Mutation

Sample ID

Sample Name

ID NCV

Annotation

Zygosity

Chromosome

Genome start

Genome stop

Genome version

Strand

WT seq

Mut seq

FATHMM-MKL

This tab shows the gene expression and copy number variation data for this study
[more details]

Table Information

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The table currently shows only high value (numeric) copy number data. Copy number segments are excluded if the total copy number and minor allele values are unknown.

Click here to include all copy number data. For more detailed information about copy number data and gain/loss definitions click here.

Sample

Gene

Expression

Expr Level (Z-Score)

Over Expressed; Z-Score > 2.0

Under Expressed; Z-Score < -2.0

Normal; Z-Score within the range -2.0 to 2.0

CN Type

Minor Allele

Copy Number

CN Segment Posn.

Average Ploidy

1. N/A represents cases where the average ploidy value is not available( mostly ICGC samples). For some TCGA samples where the minor allele information is not available the average ploidy value could not be calculated.

2. For TCGA samples, the ASCAT algorithm was used to calculate the average ploidy.

3. For CGP samples, the PICNIC algorithm was used to calculate the average ploidy.

CNV

This table lists the samples in the selected study which have low/high methylation for each gene.
[more details]

Methylation (no. samples)

Tissue

Gene

Probe

Position

Low

High

Tested

This tab shows the fusion mutations observed in this sample
[more details]