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Are you ready for some football? First, are you ready for some autopsies?

The opening of NFL training camps coincided with the closing of the investigation into the April suicide by gunshot of Ray Easterling, 62, an eight-season NFL safety in the 1970s. The autopsy found moderately severe chronic traumatic encephalopathy (CTE), progressive damage to the brain associated with repeated blows to the head. CTE was identified as a major cause of Easterling’s depression and dementia.

In February 2011, 11-year NFL safety Dave Duerson, 50, committed suicide by shooting himself in the chest to spare his brain tissue for research, which has found evidence of CTE. Brain tissue of 20-season linebacker Junior Seau, 43 when he killed himself the same way in May, is being studied. The NFL launched a mental-health hotline developed and operated with the assistance of specialists in suicide prevention.

Football is bigger than ever, in several senses. In 1980, only three NFL players weighed 300 or more pounds. In 2011, according to pro-football-reference.com, there were 352, including three 350-pounders. Thirty-one of the NFL’s 32 offensive lines averaged more than 300.

For all players who play five or more years, life expectancy is less than 60; for linemen it is much less.

After 20 years of caring for her husband, Easterling’s widow is one of more than 3,000 plaintiffs — former players, spouses, relatives — in a lawsuit charging that the NFL inadequately acted on knowledge it had, or should’ve had, about hazards such as CTE.

Might Americans someday feel as queasy enjoying it as sensible people now do watching boxing and wondering how the nation was once enamored of a sport the point of which is brain trauma?

Football is entertainment in which the audience is expected to delight in gladiatorial action that a growing portion of the audience knows may cause the players degenerative brain disease. Not even football fans, a tribe not known for savoring nuance, can forever block that fact from their excited brains.

Furthermore, in this age of bubble-wrapped children, when parents put helmets on wee tricycle riders, many children are going to be steered away from youth football, diverting the flow of talent to the benefit of other sports.

In the NFL, especially, football on the field is a three-hour adrenaline-and-testosterone bath. For all its occasional elegance and beauty, it is basically violence for, among other purposes, inflicting intimidating pain. (Seau said his job was “to inflict pain on my opponent and have him quit.”)

The New Orleans Saints’ “bounty” system of cash payments to players who knocked opponents out of games crossed a line distinguishing the essence of the game from the perversion of it. This is, however, an increasingly faint line.

Decades ago, this column lightheartedly called football a mistake because it combines two of the worst features of American life — violence, punctuated by committee meetings, which football calls huddles. Now accumulating evidence about new understandings of the human body — the brain, especially, but not exclusively — compel the conclusion that football is a mistake because the body isn’t built to absorb, and can’t be adequately modified by training or protected by equipment to absorb, the game’s kinetic energies.

After 18 people died playing football in 1905, even President Theodore Roosevelt, who loved war and gore generally, flinched and forced some rules changes. Today, the problem isn’t the rules; it’s the fiction that football can be fixed and still resemble the game fans relish.