Standard P-PRP is pure platelet-rich plasma. P-PRP products consist of platelets without leukocytes in plasma and are used either as a fluid for injection into orthopedic injuries or as a gel for topical application to skin wounds.

The levels of some of the growth factors from 3C Patch® were compared with standard P-PRP3 and the results showed an increase in the concentration of the measured growth factors.

Growth Factors

Continuous release has been demonstrated in-vitro

It has been demonstrated, in-vitro, that growth factor PDGF-AB is released continuously from 3C Patch® for at least 1 week and the addition of chronic wound fluid increased the rate of release.4

The 3C Patch® contains a vast amount of growth factors and cytokines, some at very high levels. In vitro analysis has shown that the 3C Patch® responds appropriately to stimuli relevant for wound healing.27

Release of PDGF-AB over time

3C Patch® responses to wound related stimuli in vitro.4

ADAPTIVE NATURE OF 3C PATCH®

More than 800 different growth factors, cytokines and proteins have been detected in the 3C Patch® by multiplex analysis – of these, approximately 380 were differentially expressed in response to stimuli, indicating the adaptive nature of the construct.28 Specifically, proinflammatory (IL-1β and IL-6) are produced only in response to bacterial components (LPS) whereas anti-inflammatory cytokines (IL-1RA and Il-10) are produced under both pro-, and anti-inflammatory circumstances.

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