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physical journey with tremors and some cardiovascular push and nothing of a sensory nature, I
decided on to explore it no further. A report from South America found the intoxication to be largely
pleasant (this, at 75 milligrams), with an improved interest in one's surroundings, but no
perceptual modifications, no overt stimulation, and no gross physiological effects various other than a slight
mydriasis (dilation of the pupils). I have furthermore been informed of a solitary test of 250 milligrams of the
tartrate (this is comparable to someplace in the 150-200 milligram number of the hydrochloride
salt, based upon the acid/base ratio of the tartrate salt) with some "speedy" effects but still
no sensory changes. A seizure of capsules reported by the drug law enforcement authorities
some 20 ages back found that each included some 200 milligrams of the hydrobromide salt.
This is comparable to 170 milligrams of the hydrochloride salt, and indicates that degree may be an
effective dosage.
An intriguing, but small studied, analogue of 2,5-DMA are the compound with methyls in place of
the methoxyls. 2,5-Dimethylamphetamine has been looked at, in guy, as a potential anorexic,
but there are small impact even at 150 milligrams. The 3,4-isomer, 3,4-dimethylamphetamine or
xylopropamine, is an adrenergic agent and it has been discovered to become an analgesic in man at as
little as 10 milligrams. This was assayed, instead remarkably, by attaching electrodes to the
tooth fillings of the experimental topics. But with this base, cardiovascular effects were not
seen until doses of about 100 milligrams are administered, and toxic results (nausea and
vomiting) were reported at 150 milligrams. There is no suggestion of anything psychedelic.
All three isomers of monomethylamphetamine have additionally been seemed at in man. The ortho- and
meta-isomers, 2-methyl- (and 3-methyl- ) amphetamine are weak anorexics. At doses of up to
150 milligrams orally, there were indications of arousal noted--talkativeness and reduction of appetite.
The para-isomer, 4-methyl-amphetamine or Aptrol, are much more potent. At 75 milligrams (orally, in
guy) there is clear adrenergic stimulation, and at twice this dosage there are signs of mild
toxicity such as salivation, coughing and vomiting.
There are a mystery, at least to me, regarding the commercial production of 2,5-DMA. At
regular intervals, there is a public announcement of the production quotas that are requested or
permitted by the Drug Enforcement Administration, for medication that have been placed in Schedules
I or II. In the Schedule I category there are usually detailed amounts these types of as a gram of this, and a
few grams of that. These are probably for analytical [pur
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herbs for aromatherapy
obvious, the ALEPHS had been assigned and made, up to and including ALEPH-7.
ALEPH-3 is intended to become the methallylthio compound, 2,5-dimethoxy-4-(beta-
methallylthio)amphetamine. The thioether (2,5-dimethoxyphenyl beta-methallyl sulfide) was
effortlessly made from 2,5-dimethoxythiophenol (see 2C-T-2 for its preparation) with 3.4 g dissolved
in a solution of 1.7 g KOH in 25 mL boiling EtOH, and 2.72 g methallyl chloride, heated 1 h on
the steam shower, poured into 250 mL H2O, removed with 3x100 mL CH2Cl2, and solvent
removal yielding 4.4 g of the sulfide as an amber oil. a work to convert this to 2,5-dimethoxy-4-
(beta-methallylthio)benzaldehyde (7.2 g POCl3, 6.7 g N-methylformanilide, 4.2 g of the crude
sulfide from above, 15 min heating on the vapor bath, H2O hydrolysis, hexane extraction of the
residues from a CH2Cl2 extraction) created 3.1 g of a peppermint-smelling oil that distilled at
140-160 ?C at 0.3 mm/Hg and which did certainly have actually an aldehyde group present (by proton
NMR) but the sleep of the range is a mess, and the project is abandoned.
Several years later, this entire project is reinitiated, and the aldehyde is obtained as a
yellow crystal, but once again it had been not pursued. At that time, the previous try had been totally
overlooked, and a brand name newer ALEPH- (or 2C-T-) quantity had been assigned; i.e., 20. Hence, the
corresponding phenethylamine (2,5-dimethoxy-4-(beta-methallylthio)phenethylamine), had it
ever been made, which it was not, would need been known as either 2C-T-3 or 2C-T-20, and the
amphetamine homologue would most likely need been ALEPH-20.
A closely relevant 2C-T-X substance is also began quite a whilst later --this was the allylthio
homologue of the methallyl materials 2C-T-3 or 2C-T-20. Its spot in the flow of things is evident
from its numbering, 2C-T-16. A mixture of 2,5-dimethoxythiophenol and KOH and allyl chloride
in MeOH offered 2,5-dimethoxyphenyl allyl sulfide as a white oil which boiled at 110-125 ?C at
0.25 mm/Hg. This, with POCl3 and N-methylformanilide provided 2,5-dimethoxy-4-
(allylthio)benzaldehyde which distilled at 140-160 ?C at 0.4 mm/Hg and could be recrystallized
from MeOH as a pale yellow solid. Response of this aldehyde in nitroethane in the presence of
ammonium acetate (steam bath for 2.5 h) provided 2,5-dimethoxy-4-allylthio-beta-nitrostyrene
as red crystals from acetonitrile. Its mp was 114-115 ?C. Anal. (C13H15NO4S) C,H. This has
not however been reduced to the last amine, 2,5-dimethoxy-4-allylthiophenethylamine, 2C-T-16. The
corresponding amphetamine would become, of program, ALEPH-16.
ALEPH-5 had been to be the cyclohexylthio analogue (2,5-dimethoxy-4-cyclohexylthioamphetamine).
The thioether (2,5-dimethoxyphenyl cyclohexyl sulfide) had been successfully made from 1.7 g 85%
KOH pellets in 25 mL hot EtOH, 3.4 g 2,5-dimethoxythiophenol (again, see under 2C-T-2 for its
planning), and 4.9 g cyclohexyl bromide, 3 h on the steam shower, into 500 mL H2O, extraction
with 3x100 mL CH2Cl2, [washing|cleanin

herbology 20 March 2018 05:15:17

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Herbs For Confidence

SYNTHESIS: In 50 mL of benzene there was
dissolved 31.6 g 2,5-dimethoxy-4-
methylbenzaldehyde (read recipe for 2C-D for its
preparation), 20.2 mL 1-nitropropane, and 6 mL
cyclohexylamine. This solution is held at reflux in a
Dean Stark apparatus for 24 h, effectively removing
the liquid of response. Upon cooling, there was
deposited 19.6 g of 1-(2,5-dimethoxy-4-methylphenyl)-
2-nitro-1-butene as brilliant orange crystals. The mp, after recrystallization from MeOH, had been 114-
115 ?C and a second recrystallization increased the mp another 2 ?C. Anal. (C13H17NO4)
C,H,N.
A suspension of 12.5 g LAH in 600 mL anhydrous THF is stirred magnetically, and brought up
to a reflux. To this there had been added, dropwise, 15.0 g 1-(2,5-dimethoxy-4-methylphenyl)-2-nitro-
1-butene dissolved in 150 mL THF. Refluxing was continued for 15 h and, after cooling, the
extra hydride is decomposed by the addition of 12.5 mL H2O. The inorganic salts were
made loose and granular by the addition of 12.5 mL 15% NaOH used by an additional 37.5
mL H2O. These solids had been removed by filtration, and the filter cake was washed with THF. The
combined filtrate and washings were stripped of solvent under vacuum. The residue was
dissolved in anhydrous Et2O, and treated with hydrogen chloride gasoline, yielding 1-(2,5-dimethoxy-
4-methylphenyl)-2-aminobutane hydrochloride (ARIADNE) as white crystals which, after
recrystallization from IPA, weighed 11.4 g and had a mp of 232.5-234.5 ?C. Anal.
(C13H22ClNO2) C,H,N,Cl. The racemic combination was resolved into its optical isomers by the
development of salts with (+)-2beta-nitrotartranilic acid (to render the "S" isomer) or with (+)-2beta-
chlorotartranilic acid (to offer the "R" isomer). The "R" isomer can furthermore feel prepared by the
reductive amination of 1-(2,5-dimethoxy-4-methylphenyl)-2-butanone (from the above
nitrostyrene and elemental iron) with (+)-a-methyl benzylamine accompanied by the hydrogenolysis
of the benzyl group.
DOSAGE: as psychedelic, unknown. 2T-MMDA-3a2-Methylthio-3,4-methylenedioxy-A w}�
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AROMA THERAPI

fears, a jumble of warnings and deep fears spinning quicker. Twenty mins later this complex
chaos passed as quickly as it had come. At reduced dosages 2C-E has been a truly enjoyable
esthetic enhancer. But it actually has a steep dose/response curve.
EXTENSIONS AND COMMENTARY: right here is another of the magical half-dozen. The range is
purposefully wide. At 10 milligrams there have been some pretty rich +++ experiences, and
yet I have had the report from one young woman of a 30 milligram test that is really frightening.
My very first experiences with 2C-E was truly profound, and it's the substance of a chapter within
the tale. The amphet-amine homologue are DOET, which is not only a lot longer in action, but
considerably much more potent. Several individuals have actually said, about 2C-E, "I don't think I like it, since it
isn't that much enjoyable. But I intend to explore it once again." There is one thing here that will reward the
experimenter. Someday, the complete character of 2C-E will be comprehended, but for the minute, let it
sleep as being a difficult and worth-while materials. an extremely much worth-while materials. One
Tweetio of 2C-E is known. The 5-EtO-homologue of 2C-E is 5-ethoxy-4-ethyl-2-
methoxyphenethylamine, or 2CE-5ETO. The nitrostyrene intermediate had a melting point of
110-110.5 ?C, and the last hydrochloride a melting point of 184-185 ?C. The effective level of
2CE-5ETO is in the 10 to 15 milligram number. It's gentle, forgiving, and extremely long lived.
Some 3 to 4 hours were needed to achieve plateau, and on occasion experi-ments were
interrupted with Valium or Halcion at the 16 hour point. After a night's sleep, there were still
some effects evident the following day. Therefore, the dosage are comparable to the parent compound 2C-E,
but the duration are 2 to 3 times much longer. It was given the nickname "Eternity" by one subject. detox_loss_weightdetox_drug