Carcinogenesis

We quantified tyrosine hydroxylase (TH) expressing TIDA neurons in ageing rats (2 year Bioassay), in order to explore the possibility that delayed senescence of these neurons may be associated with the development of uterine tumours, as a result of dopaminergic inhibition of prolactin secretion via the hypothalamopituitary axis.

(2) Microarray and pathways analysis of laser dissected FFPE tissues known to be regulated by the hypothalmo-pituitary axis, to explore signalling pathways (e.g. Estrogen Receptor signalling), that might be associated with uterine carcinogenesis.

The results supported a mode of action consistent with non human relevance (presented at SOT poster session in 2013 and 2014).