I used that map for the Charleston Naval Base hit, and looked up the prevailing winds for that date. If I did it right, Charleston AFB and the civilian airport, as well as The Citadel and most of peninsular historic Charleston, were unscathed, at least by the initial blast.
Myrtle Beach woulda sucked, though...

On the topic of weather and nukes:
Per Armies of the Night, the Linden and Perth Amboy strikes were on December 2, 1997. Checking the Newark, NJ International Airport historical weather data, the wind was strongly from the NW above 15 mph all day with gusts up in the low 20s, no precip.
On Dec. 3, the wind was steadily out of the west between 5-10mph up to 18:00, no precip. That would have pushed a bit of the smoke, fumes, flames, and airborne fallout substantially southeasterly for the first day, then due east the day after.
JFK International Airport for Dec 2 shows strong WNW wind (24mph steady. 33-38mph gusts) until 18:00.
Same location on Dec 3 shows winds from the West 7-14mph until about 14:00. Again, prevailing winds those days were shoving things Southeast, then due East out into the ocean.
Of course, if you want to put the screws to the Big Apple, a Butterfly effect could cause a shift to push all that crud NNE.

The TDM--Nov 27, 28, 29-- ground bursts in the DC and environs will be my next thought exercise. Bwahahahahahahah.....