hotkey

i know how to a make a shortcut using alt-ctrl- anykey
but my circumstances are a little different ,i only have the use of one hand.i'm looking for a way to make it so i can access a program/folder with just one keystroke.
can someone provide with instructions how to do this?
thanks in advice

In Start>All Programs>Accessories> run the Accessibility Wizard. After a couple of prompts you will come to a checkbox for "using keyboard and mouse", which will then allow you to turn on "sticky keys", which allows you to use ctrl>alt>combos by pressing one key at a time instead of all at once.