Sialic acid concentration in the reproductive organs, pituitary gland and urine of the Indian langur monkey (Presbytis entellus entellus).

MedLine Citation:

PMID:
405449
Owner:
NLM
Status:
MEDLINE

Abstract/OtherAbstract:

The concentration of sialic acid was determined in the reproductive organs, pituitary gland and urine of male and female langur monkeys. In the male, sialic acid concentration was lowest in the testes and highest in the epididymides. Both caput and cauda epididymides contained almost the same concentration. Castration and subsequent androgen administration did not modify the concentration of sialic acid by comparison with intact animals, suggesting that sialic acid is not androgen-dependent in the langur. There was no significant difference in sialic acid concentration in the uterus during the proliferative and luteal phases of the menstrual cycle. After ovariectomy, there was a decrease in the concentration of sialic acid in the uterus, cervix and vagina while oestrogen or oestrogen plus progesterone administration increased its concentration significantly, but not to the control level. However, the difference in concentration between oestrogen-treated and oestrogen plus progesterone-treated monkeys was not significant. There was a peak of sialic acid excretion in the urine on day 8 of the normal 22-day menstrual cycle, i.e. a day before the probable day of ovulation. In pregnant monkeys siliac acid excretion increased significantly 2 days before delivery compared with the values recorded 7 to 3 days before parturition. The part played by sialic acid during the menstrual cycle and pregnancy in the female is not clear.The distribution of sialic acid in the genital organs, pituitary gland, and urine of langur monkeys was studied to determine: 1) whether it may help to pinpoint the day of ovulation, 2) whether the circulating levels of steroid hormones affect sialic acid concentration, and 3) its concentration during pregnancy. In the male the concentration was lowest in the testes and highest in the epididymides. The same concentration was found in the caput and cauda epididymides. Castration and androgen failed to modify the concentration of sialic acid in comparison with intact animals which suggests that sialic acid is not androgen-dependent in the langur. There was a lack of significant difference in sialic acid concentration in the uterus during proliferative and luteal phases of the menstrual cycle. There was a decrease in the concentration of sialic acid in the uterus, cervix, and vagina after ovariectomy. Estrogen or estrogen plus progesterone increased its concentration but not to the control level. There was a peak of sialic acid excretion on Day 8 of the 22-day menstrual cycle. Sialic acid excretion increased significantly 2 days before delivery in pregnant monkeys.