Molecular oncology ES

Molecular and pre-clinical basis for the metabolic treatment of cancer.

Autophagy and Cancer.

Autophagy in tumor stem cells.

Autophagy and resistance to cancer treatments.

Strategic objectives

1. Definition of a new intrinsic characteristic (“hallmark”) of cancer: “METABO-STEMNESS” (the bioenergetic metabolism as a causal mechanism of the properties of self-renovation, immortality and pluripotency of tumor stem cells).

2. Treatment of cancer through strategies to reprogram the tumor metabolism: Repositioning of anti-metabolic drugs from other diseases to increase and diversify the arsenal of anti-tumor drugs.

Main lines of research

Metabolism and cancer

Bioenergetic metabolism of tumour stem cells.

Molecular and pre-clinical basis for the metabolic treatment of cancer.