Ingredients by Application

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Alliance Formed Between Kyowa U.S.A. and Austin Chemical Co.

July 2, 2008

New York, NY – Kyowa Hakko U.S.A., Inc. and Austin Chemical Company, Inc. have formed an alliance for Austin Chemical to market and sell Kyowa Hakko-produced Sustamine™ L-Alanyl-L-Glutamine in the United States and Canada for cell culture media end uses. Compared to traditional L-Glutamine, Sustamine™ L-Alanyl-L-Glutamine improves viable cell growth and increases product yield in media applications. The worldwide market for Sustamine™ is estimated to be over 250 MT per year.

Sustamine™ is a dipeptide of the two amino acids L-Alanine and L-Glutamine, or L-Alanyl-L-Glutamine. Through their innovative manufacturing process, Kyowa Hakko’s scientists are able to make the Sustamine™ L-Alanyl-L-Glutamine, and other dipeptides, without the necessity of synthetic or chemical modifications. Kyowa Hakko produces Sustamine™ L-Alanyl-L-Glutamine directly from glucose through its proprietary fermentation process, which enables a significantly lower manufacturing cost. This proprietary process has unlocked the potential for dramatically improving productivity in cell cultures, particularly of value in antibody production, but with promising applications that span the healthcare industry.

Austin Chemical, as a leading sales and marketing representative company, will serve as exclusive sales agent for Kyowa Hakko USA’s Sustamine™ L-Alanyl-L-Glutamine for cell culture media end uses in the United States and Canada.

Austin Chemical is an information, services, and products provider to the health sciences and specialty fine chemicals industries. Austin Chemical’s service products such as sales and marketing, sourcing and procurement, logistics support, and distribution, have been created to support its suppliers’ and customers’ needs as an asset extension.

Sustamine™ can be utilized in many liquid products, including IV, enteral drugs, cell culture media, nutraceutical health, sports nutrition and more and is available for worldwide distribution.

Kyowa Hakko is an international health ingredients manufacturer and world leader in the development, manufacturing and marketing of pharmaceuticals, nutraceuticals and food products. The maker of the branded ingredients Cognizin® Citicoline, Hydrafend™ Hyaluronic Acid , Lumistor® L-Hydroxyproline, Kyowa CoQ10®, Setria® Glutathione and Sustamine™ L-Alanyl-L-Glutamine, Kyowa Hakko, offers manufacturers and formulators one of the industry’s most extensive lines of over 50 amino acids and related compounds, including D-Amino acids and branch-chain amino acids, as well as nucleic acids, bio-products and fine chemicals.