Casein glycomacropeptide (CGMP) has anti-inflammatory properties in experimental rodent
colitis and using human in vitro inflammation models. Its use as a food ingredient has
proven safe and with no influence on dietary intake. In a pilot study the investigators
found, that orally administered CGMP seems to have a beneficial effect comparable to that of
mesalazine in active distal ulcerative colitis.
The investigators wish to evaluate the effects in a larger group of patients ...

The aim of this Project is, within the scope of industrial research, to evaluate the long
term effects of H.pylori eradication on microbiome (gut microbiome, upper respiratory tract
microbiome) and lasting adverse events. In addition, the project aims to evaluate its effects
on abundance and prevalence of extended-spectrum beta-lactamases coding genes and develop
cost effective ESBL screening test prototype.

The gastric barrier plays a major role in the maintanance of the distal intestinal microbiome
composition. It has been shown before that the use of gastric acid suppression medication,
such as proton pump inhibitors, are associated with distinctive alterations of the intestinal
microbiome. Foremost, the invasion of predominantly oral bacteria, like Veillonella and
Streptococcus species, were a resurring finding in previous reports.
Gastric cancer treatment includes the total o...

The aim of the study is to characterize and monitor the microbiome of premature infants born
in the investigators facility until discharge from the NICU. The investigators will also
examine the relationship between mode of delivery and the microbiome of the infant, while
exploring various possible factors that may affect it. In addition, the investigators will
compare the microbiome of premature infants to the microbiome of term babies born at the
same time in the same facility...

Protein-energy malnutrition (PEM) occurs in 65-90% of patients with liver cirrhosis.
Severity of malnutrition correlates with progression of liver disease and leads to
sarcopenia in 30-70% of cirrhotic patients. Malnutrition and sarcopenia are associated with
an increased risk of complications and mortality.
In cirrhosis the gut microbiome is altered leading to increased gut permeability, bacterial
translocation and inflammation. Since the microbiome is involved in nutrient up...

The NYU Human Microbiome Study Cohort is designed to improve understanding of the role of
human microbiome in health and disease. This study will serve as a critical NYU biorepository
resource for research on human genetics and the microbiome in health and disease

Cervical biopsies will be collected from women aged 18 and over whom are virally suppressed
and taking tenofovir as part of their antiretroviral therapy regimen. Blood plasma,
peripheral blood mononuclear cells (PBMC), and cervicovaginal swabs will also be collected.
Drug concentrations, hormone concentrations, inflammatory cytokines, and vaginal microbiome
will be evaluated to understand the role of hormones, inflammation, and the microbiome in
modulating drug efficacy in the ...

Multiple sclerosis (MS) is an inflammatory disease that affects the nervous system and
results in a wide range of signs and symptoms including physical and cognitive problems.
Recent evidence demonstrates that interactions between the host immune system and the
commensal gut microbiota have a key role in the development of the disease. However, the
natures of these interactions are poorly studied, and the set of bacteria with pathogenic or
protective potential are unknown. Here...

The purpose of this Phase 1, 3-period crossover with repeated measures feasibility study is
to characterize the gut microbiome of individuals with chronic kidney disease, and to explore
effects of p-inulin on the gut microbiome. The nature of the study will provide information
about the feasibility of stool sample collection for future multicenter studies of the gut
microbiome.

Pediatric obesity has been increasing in prevalence, but concerns have been raised around the
world because no treatment has been found. Recently, however, research on gut microbiome has
begun to become a new alternative. It has been shown that changes in the microbiome in adults
may induce obesity. However, the results on children are still scarce. Unlike adults,
children have few external factors such as alcohol, tobacco, stress, and cancer, making them
suitable for obesity-r...

Estimate the impact of a 6‐week intake of twice daily of 1000 mg of ginger extract on the
composition of the gut microbiome using a pre‐post test design, i.e. examine the change of
microbiome over time within the subjects.

Niemann-Pick disease, Type C is a rare genetic disorder characterized by a failing in
intracellular cholesterol transport, inducing an accumulation of sphingolipids in the brain.
Neurological signs are at the forefront of the disease. There are also psychiatric signs of
psychotic kind among 28 to 45 % of patients according to studies, and a thirty cases were
published. These signs can be concomitant with neurological signs or precede them.
Is is likely that psychotic disorder...

Investigators will examine temporal and regional dynamic changes in the microbiome of Cystic
Fibrosis patients to explore microbiome features that are associated with an inflammatory
phenotype. Investigators hypothesize that temporal and spatial differences in lung
microbiome are associated with host inflammatory responses.
While chronic and polymicrobial airway colonization are commonly recognized in cystic
fibrosis (CF), it is unclear what factors of the microbial environmen...

The concept of organisms living on or in the human body without causing overt signs of an
infection is common in medicine and has been termed a microbiome. Urine from patients with
Overactive bladder (OAB) grows different organisms from controls without OAB. However, it
is not known if the bacteria that have been identified are innocent commensals or pathogenic
organism responsible for the symptoms of OAB. Previous data suggests that treatment with
antibiotics does lead to an ...

FEAST-HF is a single-centre clinical trial in ambulatory patients with chronic HF to evaluate
whether dietary supplementation with acacia gum reduces HF-related biomarkers NT-proBNP and
ST2 and how the gut microbiome responds to dietary supplementation with acacia gum. The
hypotheses of this study are 1) that changes in the gut microbiome will be correlated with a
reduction in NT-proBNP and ST2 in patients with HF after treatment with acacia gum, and 2)
gut microbiome configura...

Lay Language Summary: High cholesterol levels are common in persons with HIV infection.
However, conventional cholesterol-lowering medications may have harmful side effects when
given to HIV-infected persons. Therefore, we plan to evaluate the safety and effectiveness
of policosanol, a dietary supplement derived from sugar cane that has cholesterol-lowering
properties, to lower cholesterol levels in persons with HIV infection. We hypothesize that
policosanol will lower level...

The use of antibiotics has saved millions of human lives, however consumption of antibiotics
can select for antibiotic resistant organisms and may lead to changes in commensal
microbiome. This study is designed to estimate the effect of antibiotic consumption on
microbiome in a rural region of rural Burkina Faso. Changes in the intestinal and
nasopharyngeal microbiome and resistome following a short course of antibiotics will be
measured.

In this study the investigators aim to investigate the changes of the intestinal microbiome
in three different cohorts (IBD, IBS, healthy) after applying the uniform disruptive factor
of osmotic diarrhea induced by macrogol. The investigators hypothesis is that ill people will
show more severe changes of the microbiome than healthy people and that these changes persist
longer.