I want to set up a home theatre system in the living room 400 sq ft. I am thinking Yamaha HTR6090 7.1 as receiver. Will M60, VP150, EP350, QS8 works? Do I need a bookself speaker or another QS? How different are axiom compare to jbl, polk audio speakers? I never purchase Axiom.

What will you use the system for, more home theatre? or more music listening?

If its primarily for Home Theatre, I would go with the M22 route with the EP500, see how you like it, and if you want to upgrade it to the M60s, Axiom has been known to pay for return shipping of speakers if you are upgrading.