The Reina-Valera Antigua Bible was first translated and published in 1569 by Casiodoro de Reina in Basel, Switzerland after twelve years of intensive work for the first Spanish Bible. The translation is based on the original Greek and Hebrew text and also included the deuterocanical books of the Old Testament.

This highly popular and widely used Spanish Bible had its first editorial revision in 1602 by Cipriano de Valera, who gave more than twenty years of his life to its revisions and improvements. Later revisions of Reina-Valera Bible in 1862, 10909, 1960, and 1995 began to omit the Apocrypha and substituted a more modern language translation.

The most commonly used Bible for Spanish-speaking Christians around the world is the 1960 revision.