Comedian Margaret Cho arrives on the opening night of the Los Angeles run of "Hamilton: An American Musical" at the Pantages Theatre on Wednesday, Aug. 16, 2017, in Los Angeles. (Photo by Chris Pizzello/Invision/AP)

Barry Brecheisen/Associated Press archives

You can join Janeane Garofalo in an immersive and varied night of comedy at San Francisco's Speakeasy nightclub as part of Sketchfest, Jan. 11. She also performs at the "Pardon My Tangent" live podcast Jan. 13.

Richard Drew/Associated Press archives

Famed illustrator and director Bill Plympton will draw, show film clips and discuss his career at Sketchfest Jan. 12.

Ray Chavez/staff

Watch out, Peaches Christ, you are going to get roasted (lovingly, of course) at SF Sketchfest Jan. 13.

Rhett Miller, best known as frontman for the alt-country band Old 97's, hosts a night of music and comedy at Sketchfest Jan. 20.

Joanna Jhanda/staff archives

From left, David Owen, Cole Stratton and Janet Varney are the founders and organizers of Sketchfest. Stratton and Varney also performing in "Improv in the Dark" at the festival's closing night Jan. 27.

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There is not much that doesn’t fit under San Francisco Sketchfest’s big tent, with an ever-expanding lineup of 200-plus shows on the schedule that runs from Jan. 10 through 27. Here are some of our picks for the best the fest has to offer. Note that some key events, such as the “Best in Show” reunion and “Schitt’s Creek: Up Close and Personal,” are sold out. All venues are in San Francisco. Tickets and more information are at www.sfsketchfest.com.

Tribute to Margaret Cho, with Ben Fong-Torres: The festival kicks off with this local favorite, tracing her career as a comedic provocateur from her sitcom “All-American Girl” to her Off-Broadway shows “I’m the One That I Want” and “The Sensuous Woman.” Details: 7:30 p.m. Jan. 10; Marines’ Memorial Theatre; $25-$35.

SF Sketchfest at The Speakeasy: An immersive comedy experience featuring Janeane Garofalo with Jen Kirkman and Sabrina Jalees. One of the more innovative events at this year’s Sketchfest, this immersive live comedy experience will feature a different headliner performing an early and late set, with “choose-your-own-adventure”-style experiences at the venue. Work on a joke with a comic, learn to hone your blackjack skills or join a comedy set performed just for you and your friends. Details: 7 p.m. Jan. 11, 12, 18, 19, 25 and 26; Speakeasy; $125.

Salute to Bill Plympton: Tagged as the King of Indie Animation, the Oscar-nominated Plympton is the first person to hand draw an entire animated feature film (1992’s “The Tune”). Regularly featured on MTV’s “Liquid Television” in the early ’90s, Plympton won the Cannes Palme d’Or in 1991 and has illustrated for the New York Times, National Lampoon and Screw. This tribute features film clips, live drawing and a Q&A. Details: 4 p.m. Jan. 12; Brava Theater Center; $25.

Carol Burnett, in conversation with Wendie Malick: Though she was beloved for her work with Julie Andrews in the ’60s and as Mrs. Hannigan in “Annie” in 1982, Burnett is best known for her comedy show that from 1967-78 introduced a new generation to sketch comedy. Details: 8 p.m. Jan. 14; Castro Theatre, $55-$75.

Wheels Off with Rhett Miller: For the fifth straight year, the Old 97’s lead singer and his pals re-create a old-school variety show, complete with music, comedy, some chatter and a sketch or two. Details: 10 p.m. Jan. 20; Swedish American Hall; $35.

The Bat — Improv in the Dark: Check out Sketchfest co-founders Cole Stratton and Janet Varney along with such guest improvisers Parvesh Cheena (“Crazy Ex-Girlfriend”), Danny Pudi (“Community”), Gary Anthony Williams (“The Boondocks”) in this original Audible comedy series set in a world crafted on the fly, based on suggestions from the audience. Details: 8 p.m. Jan. 27; Gateway Theatre; $25.