There has been a large development in the search for the variant that I wanted to relate to the thread. Up until recently I have been trying to search for the cause of the AD in my family with the help of 23andme, GEDmatch, and Geni. This has not been an overly effective strategy as almost none of t...

This is without question a global emergency. For some reason the imminent IQ uplift of humanity has not been thought worthy of public discussion. Yet, a profoundly severe social crisis continues to smolder. This needs to be openly discussed by the global leadership before human society completely di...

Thank you for replying and giving me the opportunity to clarify that point. Specifically I was referring to the recent research with the near causal variants that were found when 20,000 AD patients were exomed scanned. Of those 20,000, they found 17 SORL1 variants, some of which appeared to be super...

Very good point SusanJ! It was not so much heart disease on our main non-e4 line as some sort of a mystery illness. My best guess is some form of epilepsy. Many of these relatives might then have gone on to dementia. It is still surprising how even close family seem to be largely unaware of the gene...

LG1 welcome back to the forum! I am so excited about what is happening now in IQ genetics!!! I have no idea how we will be able to navigate through the next 5 years. For many of us the extreme social disruption that is now clearly imminent will happen well before dementia sets in. The latest and soo...

What seems so surprising is that we have already reached the Genetic Singularity and there appears to be so little popular recognition of what is currently occurring. The Nature Genetics article that will soon be published discloses over 500 points of Educational Attainment. It should be clear to al...

Interesting! Yet, what is approaching has never happened before. Up till now cognitive evolution has been far slower than watching the paint dry. There might have been a 1 point change in IQ over 1,000 years. Even such a small change as that has resulted in clear shifts in what humans could achieve....

I was quite excited about CRISPR, though it might take years and years to work through the clinical trials process. What I had overlooked was that embryo selection technology has been in use for many decades. Combining embryo selection with the results from large scale GWAS should be expected to hav...