Errosive OA (EOA) looks a lot like RA, actually. Except it is not systemic. However, it is often very aggresive and debilitating. Mostly attacks the hands (finger joints) and feet. Sometimes knees and/or hips. Mostly women (12:1 ratio to men). Comes on fast (like mine did). Often serum markers are negative, although sed rate may be slightly elevated or high normal. Looks like OA in ultrasound or MRI, except notable inflammation (which is not normal for OA) and errosion of at least 2 joints. Plaqenil is only DMARD that is used as far as I can see so far, and prednisone, NSAIDs, etc. No other drug mentioned to halt/slow down disease. Does have flares that permanently damage joints. I just took first dose of generic plaquenil (400 mg in morning). Had some GI upset so doc said to redcuce to 200 mg for few weeks then increase to 400 so I can tolerate it and since I have to work with people

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