Human scientistIsaac Newton devises three laws of motion that form the basis of Earth's understanding of physics and the universe. Newton's epiphany comes when a member of the Q Continuum, later named Quinn, jostles the apple tree that Newton is sitting under, causing an apple to fall on Newton's head. (VOY: "Death Wish")

The Spanish return and brutally reconquer the area they were driven out from in 1680 by American Indians, killing several hundred of them and maiming several thousand more. Javier Maribona-Picard, an ancestor of Jean-Luc Picard, is one of the Spanish soldiers in this campaign. (TNG: "Journey's End")