pkgsrc on Mac OS

Hi,
I am just wondering if it is worth going to the trouble of setting up a
separate partition/disk image etc. with a case sensative filesystem,
purely for use with pkgsrc? A new partition on the existing disk might
be quite a bit of effort and I don't have a spare disk to install.
I understand that "a few" packages don't build on case-insensitive
filesystems but that in general it's not a major issue as long as you
use the correct flag when bootstrapping?
Any advice or info on others' experiences greatly appreciated.
Thanks,
Steve