Vertigon General Information

A phenothiazine antipsychotic used principally in the treatment of nausea; vomiting; and vertigo. It is more likely than chlorpromazine to cause extrapyramidal disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p612)

Vertigon - Pharmacology:

Vertigon blocks the D2 somatodendritic autoreceptor, resulting in the blockade of postsynaptic dopamine receptors in the mesolimbic system and an increased dopamine turnover. The antiemetic effects of prochlorperazine can be attributed to dopamine blockade in the chemoreceptor trigger zone. Vertigon also blocks anticholinergic and alpha-adrenergic receptors, the blockade of alpha(1)-adrenergic receptors resulting in sedation, muscle relaxation, and hypotension.

Vertigon for patients

This medicine is used to treat psychotic disorders such as hallucinations, delusions and hostility. Phenothiazine drugs may also
be prescribed to prevent and treat nausea and vomiting.

General Information
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This information is for educational purposes only. Not every known side effect, adverse effect, or drug interaction is in this
database. If you have questions about your medicines, talk to your healthcare provider.

Proper use of this medicine
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Take this medicine exactly as directed. Swallow extended-release capsules whole, do not open. Do not take more of this medicine
than is prescribed by your doctor. If your doctor has given you a suppository, follow these steps: If the suppository feels soft,
hold it under cold, running water for 1 minute. Dip the tip of the suppository in water. Lie down on your left side and raise your
right knee to your chest. (A left-handed person should lie on the right side and raise the left knee.) Using your finger, insert
the suppository into the rectum, about 1/2 to 1 inch in infants and children and 1 inch in adults. Hold it in place for a few moments.
Stand up after about 15 minutes. Wash your hands thoroughly and resume your normal activities.

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and
away from excess heat and moisture. Throw away any medication that is outdated or no longer needed.

This medicine should be taken during pregnancy only when clearly needed. Talk to your doctor about the risks and benefits when using
this medicine during pregnancy. This medicine may be excreted in breast milk. Nursing mothers are advised to talk to their doctors
before breast-feeding.

More Information
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For more information about this medicine, talk to your healthcare provider

Vertigon Interactions

Thiazide diuretics may accentuate the orthostatic hypotension that may occur with phenothiazines.

Antihypertensive effects of guanethidine and related compounds may be counteracted when phenothiazines are used
concomitantly.

Concomitant administration of propranolol with phenothiazines results in increased plasma levels of both
drugs.

Vertigon Contraindications

Do not use in comatose states or in the presence of large amounts of central nervous system depressants (alcohol,
barbiturates, narcotics, etc.).

Do not use in pediatric surgery.

Do not use in children under 2 years of age or under 20 lb.

Do not use in children for conditions for which dosage has not been established.