Could this be your next TV series to binge-watch? A new Netflix show, Maniac, will tell the story of two patients caught in a clinical trial gone seriously awry. Pharma’s onscreen reputation strikes again…

Hydrogen deuterium exchange (HDX) mass spectrometry (MS) is a powerful tool for studying the dynamics of higher order structure of protein-based therapeutics. Learn from experts at Genentech and Thermo Fisher Scientific how HDX-MS can be employed to monitor critical quality attributes of protein therapeutics.

This webinar will provide a step-by-step guide for construction of a peptide retention library using 2D LC-MS/MS (Q Exactive HF-X Orbitrap) analysis of whole cell tryptic digests. The major parameters of separation system affecting separation selectivity as well as chromatographic quality control will also be covered.

Antibody-drug conjugates (ADCs) are promising anticancer biopharmaceuticals with one of the highest annual growth rates. For their purification, the best Hydrophobic Interaction Chromatography (HIC) resin is TOYOPEARL PPG-600M. It offers the benefits of a high recovery together with a high binding capacity, and a wide working pH range.

Understanding and minimizing polycaprolactone degradation during processing using multi-detector GPC and rheology

In this application note, a commercially available sample of PCL was extruded alone and in the presence of CO2­. Multi-detector GPC measurements were made of the virgin sample before and after extrusion, while rotational rheometry was used to study the polymer’s melt viscosity.

Catalent has a broad range of experience and expertise in early phase development, and has tools including its proprietary OptiForm® Solution Suite platform to optimize development programs; accelerating molecules from late-stage discovery to Phase 1 clinical trials.

Where would drug development be without liquid chromatography-mass spectrometry – the hyphenated technique more commonly known as LC-MS? Here, we speak with expert LC-MS user Brunhilde Guessregen, who describes its importance in impurity profiling and structure elucidation at Merck.

Development of a Scalable Viral Vector Upstream Process for Gene Therapy

The next generation iCELLis® Nano bioreactor makes process development and small-scale production of virus easy and straightforward. When larger scales are required, processes developed in the iCELLis Nano bioreactor can be easily transferred to the iCELLis 500 bioreactor system, the perfect solution to GMP production.

Be it a large congress at a huge venue or an expert meeting that fits around a table, these events are a fantastic way to network and educate yourself on the latest developments in the industry – so why not take a look at our list of upcoming events?