NEW YORK CITY, NY - AUGUST 16: (L-R) Kasey Marino, Kevin Meaney, Christopher Hanke, Tevin Campbell, Adam Epstein and Joe Abraham attend 5th Year Anniversary Of HAIRSPRAY With LANCE BASS Premiere Performance After Party at Spotlight Live on August 16, 2007 in New York City. (Photo by JOE CORRIGAN/Patrick McMullan via Getty Images)

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"Kevin Meaney was as funny as they get and the nicest man," Apatow tweeted. "He could make you lose your mind laughing."

Meaney was a stand-up comedian for more than 25 years, with his first HBO special airing in 1986, according to his website. Since then, he has appeared on The Tonight Show with Johnny Carson, The Late Show with David Letterman, Oprah and Late Night with Conan O'Brien.

He appeared on the 1990 sitcom Uncle Buck as well as the Tom Hanks film Big.