Of particular interest is digital genome sequencing as a means to manage trust and reputation in an unprecedented way. Indeed, properly monitoring and analyzing the digital genome of an individual is an efficient approach to assess the trust and reputation that can be placed in him with regard to various themes, in the same way that physical genome sequencing determines the physical quirks, characteristics and traits of an individual.

Digital genome sequencing to manage trust and reputation is at the intersection of computer science, social sciences, and statistics. It analyzes activities and relations in digital arenas such as social networks, digital marketplaces, and forums. It takes into account academic degrees, career paths, professional records, and publications. It uses geographic locations and interprets social and credit scores. It tracks online individual and collaborative phony activities.

In this context, the biggest challenge will be dealing with individual privacy, but as the digital world is taking a bigger and bigger chunk of our lives, we will be more and more willing to trade some of our privacy for a substantial improvement in trust and reputation management among the participants in the increasingly critical digital life.