wild-type

wild-type

(wīld´tīp) that occurring in a natural population or in the standard laboratory stock, as a strain, phenotype, or gene, and therefore designated as representative of the group.

wild type

Geneticsadjective Referring to an organism or gene locus that predominates in natural or normal populations.

noun The normal condition of a whole organism (wild-type strain) or a particular mutation at a locus or site, which is indicated by a plus sign. The allele of a particular gene that confers the phenotype considered to be the "normal" type commonly found in natural populations. Because some DNA sequence polymorphisms do not produce different phenotypes, there can be multiple "wild-type" alleles of a gene.

Molecular biologynoun The naturally occurring phenotype of an organism; a strain of organism used as a standard reference with which to compare mutant derivatives.

wild-type

(wīld′tīp″)

Pert. to the genotype or phenotype that predominates in a species in nature.

Following an update to the Erbitux label that was approved by the European Commission in December 2013, Erbitux is now indicated for the treatment of patients with epidermal growth factor receptor-expressing RAS wild-type mCRC in combination with irinotecan-based chemotherapy, in firstline in combination with FOLFOX, or as a single agent in patients who have failed oxaliplatin- and irinotecan-based therapy and who are intolerant to irinotecan.

The results of the analysis of a subset of patient tumor samples from the phase 3 Cetuximab Combined With Irinotecan in First-Line Therapy for Metastatic Colorectal Cancer (CRYSTAL) trial (first-line mCRC therapy of leucovorin + 5-fluorouracil + irinotecan [FOLFIRI] with or without cetuximab; NCT00154102), (2) tested with the therascreen KRAS kit, support the application for the use of cetuximab in combination with FOLFIRI for the frontline treatment of KRAS wild-type patients with mCRC.

The lack of a response to steady-state growth conditions argued strongly that branching was subject to homeostatic controls that tended to negate the effects of the growth rate differences, resulting in very consistent branching patterns in wild-type Neurospora.

Through the company's research and development work, Baxter has been successful in growing wild-type virus in its vero-cell culture, which means that the company could begin vaccine production without having to wait for high-growth or attenuated virus reassortants normally used when vaccine is produced in eggs.

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