Despite the myths we’ve heard throughout our lives about cannabis killing brain cells, it turns out that a growing number of studies seem to indicate that cannabis actually has neuroprotective properties. Cannabis has an incredible ability to regulate emotional behavior and may be the most reliable medicinal plant available as a therapeutic target for the treatment of anxiety and depressive disorders.

Beta-caryophyllene is present in the essential oils of various plants including rosemary, hops, black pepper and cannabis. Like most terpenes, beta-caryophyllene contributes to the unique aroma associated with plant oils.

But in 2008, German researchers discovered that beta-caryophyllene also acts as a cannabinoid by binding to marijuana pathways in the body.

Although some compounds like THC activate both cannabinoid pathways — CB1 and CB2 receptors — beta-caryophyllene specifically targets the CB2 receptor, which does not produce a high.

Interestingly, a new study conducted with mice suggests that beta-caryophyllene may be useful in treating anxiety and depression. The findings were published online in the journal Physiology & Behavior.

“The present study has clearly demonstrated the anxiolytic and anti-depressant effect of Beta-caryophyllene and its underlying mechanism in a CB2 receptor-dependent manner in rodents,” wrote the authors, a team of scientists with the United Arab Emirates University.

“The results also support the involvement of the CB2 receptor in the regulation of emotional behavior and suggest that this receptor could be a relevant therapeutic target for the treatment of anxiety and depressive disorders.”

Previous studies have also demonstrated a role of CB2 receptors in reducing anxiety and depression, the team adds.

On the other hand, CB1 receptors, which are more widely dispersed in the brain, are known to exert a ‘biphasic’ effect when it comes to anxiety and depression. Studies show cannabinoids that target CB1 receptors can help at low doses, while high doses seem to make things worse.

A better understanding of beta-caryophyllene’s properties, however, may help explain why cannabis users often cite relief of anxiety and depression as reasons for their use.

Antidepressant and Antianxiety

Anxiety and depression are pathologies that affect human beings in many aspects of life, including social life, productivity and health. Cannabidiol (CBD) is a constituent non-psychotomimetic of Cannabis sativa with great psychiatric potential, including uses as an antidepressant-like and antianxiety-like compound.

Cannabis acts on both types of receptors which are distributed mainly in the brain and immune system, respectively. In the brain, CB1 receptors are also targeted by endogenous cannabinoids (i.e., endocannabinoids).

The hippocampus is able to generate new neurons (i.e., neurogenesis) throughout the lifespan of mammals, including humans, has changed the way we think about the mechanisms of psychiatric disorders and drug addiction.

Chronic administration of the major drugs of abuse including opiates, alcohol, nicotine, and cocaine has been reported to suppress neurogenesis in the brain. But cannabinoids appear to be the only illicit drug whose capacity to produce increased newborn neurons is positively correlated with its antidepressant-like effects.

Research published in the journals Behavioural Brain Research andExperimental Brain Research demonstrated that even extremely low doses of THC (cannabis’s psychoactive component) — around 1,000 to 10,000 times less than that in a conventional cannabis cigarette — can jumpstart biochemical processes which protect brain cells and preserve cognitive function say researchers from Tel Aviv University (TAU). Another example is one recent study which found that teens who used cannabis as well as alcohol suffered significantly less damage to the white matter in their brains. Some alcoholics have even recovered from their illness by using cannabis daily.

Dose is key and findings suggest that high doses of cannabinoids produce anxiety-like effects. To make things more complicated, acute, low doses of cannabinoids have been found to induce antianxiety-like effects. The opposing effects of high doses of acute and chronic cannabinoids, together with the antianxiety-like effects caused by a low dose of cannabinoids, may finally explain discrepancies in the clinical study literature regarding the effects of cannabinoid on anxiety and depression.

What is certain is that low-doses of cannabinoids do work. For some medical marijuana is helpful, not curative. But others have been able to completely eliminate their dependence on other medications altogether.

Anecdotal evidence for the benefits of cannabis for depression and anxiety are by itself useful to guide us to try using it for intractable disorders, that is, especially when we know that conventional treatments are inadequate, ineffective and now proven to cause more harm than good.

About the Author

Marco Torres is a research specialist, writer and consumer advocate for healthy lifestyles. He holds degrees in Public Health and Environmental Science and is a professional speaker on topics such as disease prevention, environmental toxins and health policy.

The effects of low and high doses of cannabinoids on anxiety is consistent with the Arndt-Schulz law, the pharmacologic principle of homeopathy, discovered by 19th century scientists, Hugo Schulz and Rudolf Arndt. It says that weak stimuli accelerate physiologic activity, medium stimuli inhibit physiologic activity, and strong stimuli halt physiologic activity.