Abgent is a leading provider of Custom Peptide Synthesis. Our services are driven by a personalized approach toward your needs. With fifteen years of experience, our experienced team employs the latest in instrumentation and specialized synthetic techniques to deliver high quality products on time at a great price.

Abgent has over fifteen years of experience producing recombinant proteins in E. coli and mammalian cells (CHO and HEK293, etc), and we have added a powerful yeast expression platform to our menu of services. With state-of–the art molecular biology and protein biochemistry labs, we work with our clients to rapidly evaluate in parallel to identify the optimal expression system for candidate proteins.

Certify that your antibodies work, while saving time and money. Abgent’s experienced staff custom validates more than 1,000 antibodies each month in Western Blot (WB), Immunofluorescence (IF), Immunohistochemistry (IHC), Flow Cytometry (FC) and additional applications. Proper validation with controls and optimization ensure the quality of the antibody, and establish confidence in your results.

Thousands of laboratories across the world have published research that depended on the performance of biological reagents manufactured by Abgent to advance their research. Check out links to articles that cite our custom service antibodies, peptides, and proteins in major peer-reviewed journals, organized by research category.

18,000+ products cover the ten top research categories, including cancer, metabolism, cardiovascular, neuroscience, and stem cells. Each antibody is crafted with care according to rigorous protocols for immunogen design and preparation, presentation to host animal, and high-affinity purification against the antigen. Quality is embedded in the production process to assure the best antibody for you.

Abgent develops 1000+ new products per year. We provide tools for path-breaking research by developing antibodies that detect a comprehensive library of novel and established targets. For established targets we seek to add antibodies that recognize new epitopes, including post-translational modifications such as phosphorylation and methylation. For new targets we consult with leading experts to accelerate development of antibodies that will propel state-of-the-art research in cellular health and disease.

Abgent offers custom and catalog peptides to pharmaceutical, biotechnology companies and academic institutions worldwide. All peptides are manufactured in the United States to exacting standards in support of U.S. and international clientele. Custom peptide services include long peptides (>100mer), cyclic peptides, difficult sequences, fluorescent labels, and phosphopeptides.

The majority of Abgent antibodies are produced using peptide immunogens. These immunospecific peptides can be used as blocking agents when using the complementary antibodies in a range of applications.

Researchers worldwide depend on Abgent FLcDNA clones to accelerate their research. Expression-ready clones are convenient solution that decreases the time required to start an experiment and increases the chances of success.

Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.

Abgent, a WuXi AppTec company, is a leading manufacturer of primary antibodies with more than fifteen years of experience. We supply quality antibodies and related products drug discovery and academic laboratories worldwide. Our focus is on targets covering the major research areas impacting health and disease, including cancer, metabolism, cardiovascular, neuroscience, and stem cells.

Founded in 2001, Abgent is one of the world's largest manufacturers of research user only antibodies. WuXi Apptec, a leading global contract R&D services provider serving the pharmaceutical, biotech, and medical device industries, acquired Abgent in October of 2011.

With its history as an original manufacturer, Abgent has a deep and practical understanding of the production process for antibodies, peptides, and recombinant proteins. We have assembled world-class, independently credentialed facilities, operate under a strict project management paradigm with highly trained staff, rigorously test our products in-process and post-production, and monitor customer feedback to assure that we earn the trust of scientists who choose to work with us.

Abgent may in-licenses select products and technologies to offer our customers a wide variety of options for their proteomic research needs. Contact us for further information and non-disclosure agreements. Our experienced discovery and production teams will work with you to jointly evaluate proposals and identify partnering opportunities.

We believe that attracting and supporting creative and talented people is essential to our success. Abgent offers an energetic, friendly environment and the opportunity to further scientific research and drug discovery. Abgent is an Equal Opportunity Employer. Send a cover letter and resume to jobs@abgent.com

The SUMOplot™ Analysis Program predicts and scores sumoylation sites in your protein. SUMOylation is a post-translational modification involved in various cellular processes, such as nuclear-cytosolic transport, transcriptional regulation, apoptosis, protein stability, response to stress, and progression through the cell cycle.

The Autophagy Receptor Motif Plotter predicts and scores autophagy receptor binding sites in your protein. Identifying proteins connected to this pathway is critical to understanding the role of autophagy in physiological as well as pathological processes such as development, differentiation, neurodegenerative diseases, stress, infection, and cancer.

Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Precautions

Caspase-10 Antibody (Pro) is for research use only and not for use in diagnostic or therapeutic procedures.

Protein Information

Name

CASP10

Synonyms

MCH4

Function

Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates caspase- 3, -4, -6, -7, -8, and -9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp-|-AMC and Asp-Glu-Val-Asp-|-AMC.

Tissue Location

Detectable in most tissues. Lowest expression is seen in brain, kidney, prostate, testis and colon

Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.

Background

Caspases are a family of cytosolic aspartate-specific cysteine proteases involved in the initiation and execution of apoptosis. Caspase-10 (MCH4, FLICE2) is one of the initiator caspases (1,2), and is localized to various tissues. Pro-caspase-10 has two death effector domains (DEDs) that bind FADD and recruits both TNFR1 and CD95 to form complexes with these receptors and induce apoptosis (1,2). This death domain complex cleaves pro-caspase-10 into a large active fragment and a small fragment. Cleaved caspase-10 leads to the processing of caspase-3 and caspase-7, initiating a caspase cascade and subsequent apoptosis (3,4). It has been shown that the Caspase-10 protein is not produced in neither mouse nor rat (5).

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If you have any additional inquiries please email technical services at tech@abgent.com.