Interstitial cystitis

Definition

Interstitial cystitis is a long-term (chronic) problem in which pain, pressure, or burning is present in the bladder. It is also called painful bladder syndrome.

Alternative Names

Cystitis - interstitial; IC

Causes

The bladder is a hollow organ with a thin layer of muscle that stores urine. When your bladder fills up with urine, it sends a signal to your brain, telling the muscles to squeeze. In most people, these signals are not sent until your bladder is almost full. If you have interstitial cystitis, the signal to empty your bladder is sent more often or when your bladder is not very full.

The condition most often occurs between ages 30 to 40, although it has been reported in younger people.

Women are 10 times more likely to have IC than men.

The exact cause of this condition is unknown.

Symptoms

Symptoms of IC are chronic. They have a tendency to come and go with periods of lesser or worse severity. Common symptoms include:

Many people who have long-term interstitial cystitis are also depressed because of the pain and changes to their lifestyle.

Exams and Tests

Your health care provider will look for other causes of your symptoms. These include:

Sexually transmitted infections

Bladder cancer

Bladder infections

Kidney or ureteral stones

Tests are done on your urine to look for infection or cells that suggest cancer inside the bladder. During a cystoscopy, the provider uses a special tube with a small camera on the end to look inside your bladder. A sample or biopsy of the lining of your bladder may be taken.

Tests at your provider's office may also be done to show how much urine must be in the bladder before you feel the need to urinate.

Treatment

There is no cure for IC, and there are no standard treatments. Treatment is based on trial and error until you find relief. Results vary from person to person.

DIET AND LIFESTYLE CHANGES

Some people find that making changes in their diet can help control symptoms. Try to avoid foods and beverages that can cause bladder irritation. Stop eating certain foods, one at a time, to see if your symptoms get better. Reduce or stop consuming caffeine, chocolate, carbonated beverages, citrus drinks, and foods with a high level of vitamin C.

Meats that are cured, processed, smoked, canned, aged, or that contain nitrites

Most fruits, except blueberries, honeydew melon, and pears

Nuts, except almonds, cashews, and pine nuts

Onions

Rye bread

Seasonings that contain MSG

Sour cream

Sourdough bread

Soy

Tea

Tofu

Tomatoes

Yogurt

You and your provider should discuss methods you can use for bladder training. These may include training yourself to urinate at specific times or using biofeedback to relieve pelvic floor muscle spasms.

MEDICINE AND PROCEDURES

Combination therapy may include medicines such as:

Pentosan polysulfate sodium, the only medicine taken by mouth that is approved for treating IC

Tricyclic antidepressants, such as amitriptyline, to relieve pain and urinary frequency

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