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In solving unresolved problems, we must think the unthaught, in the sense of Das ubgedachte zu denken, according to M. Heidegger. For instance, in Medicine, ALS, Amyotrophic Lateral Sclerosis early diagnosis. Notoriously, the diagnosis of Amyotrofic Lateral Sclerosis, called also "Lou Gehrig's disease", the most common form of the motor neuron diseases, is generally later due to the difficulty of recognizing its clinical early symptomatology. The earliest symptoms of ALS are typically obvious weakness and/or muscle atrophy; other presenting symptoms include muscle fasciculation, cramping, or stiffness of affected muscles; muscle weakness affecting an arm or a leg; and/or slurred and nasal speech. Despite its till now unknown causes, as every other cerebral disorder, ALS can involve exclusively individuals with Brain Disorder Inherited Real Risk, I illustrated in former papers (1-4)In following, it is described a precious sign, Boezio’s Sign, which plays a central role in bedside diagnosing ALS, even at birth, in its Inherited Real Risk .In health, “intense” leg skin stimulation by mean of a pinching brings about simultaneously, due to no-local realm in biological system (5, 6), microcirculatory activation type I, associated at the level of controlateral somato-sensorial parietal cortex, followed suddenly by identical activation of omolateral motor area, detected with Quantum Biophysical Semeiotics (7-10), as well as with PET.On the contrary, in individual involved by ALS Inherited Real Risk, and clearly by overt ASL, under experimental condition, illustrated above, brain microcirculatory activation occurs after a latency time, whose value is directly related to the seriousness of underlying disorder.