Released alongside LMA 2005 and Manchester United Manager, this version was notable for two reasons - it was the first game in the series to be released on PC, and the first developed externally (by Kuju rather than Codemasters). The change of platform required a redesigned interface, with the straightforward joypad-based navigation of PS2 replaced by a mouse-driven control system more similar to a graphical user interface such as Microsoft Windows. Each screen the user progressed to was housed on a separate window, which made finding one's way from section to section rather awkward.

Content-wise, the PC version contained the same playable leagues, 3D match engine and transfer system as the console version, although there were extra non-playable countries added from around the world to bolster the transfer market.