The following is from Chapter 7 and is just part of the above document by Dr John Lowe: Excerpt:

In the history of medicine is the endocrinology specialty’s modern guidelines for diagnosing and treating patients whose bodies are under-regulated by thyroid hormone. These guidelines and the beliefs they’re based on have caused a worldwide public health crisis. It involves the chronic ill-ness of scores of millions of people and the premature deaths of incalculable numbers more. Each year, billions of dollars are spent for drugs intended to control patients’ chronic symptoms; the drugs are largely ineffective and often induce adverse effects in the patients. Researchers who fail to recognize that the cause of the patients’ symptoms is under-regulation by thyroid hormone do studies looking for other causes. Since they are blinded to the real culprit, their fruitless efforts squander billions of research dollars.

We learned of this public health disaster through our study of fibromyalgia patients. Our research taught us the main underlying cause of most of the patients’ fibromyalgia symptoms: under-regulation of their bodies by thyroid hormone. After learning this, we developed metabolic rehab, a treatment method that helps patients recover normal metabolism. The treatment involves the use of thyroid hormone, but in ways that differ from the method the endocrinology specialty has imposed on most doctors and patients.

Most patients who undergo conventional thyroid hormone therapy remain ill. In stark contrast, some 85% of patients who undergo metabolic rehab fully and lastingly recover. In this chapter, we explain how patients use thyroid hormone in metabolic rehab.

Among those expressing this view is endocrinologist Anthony Toft. In 1999, he wrote of the use of T4 alone, “It should not be forgotten that the majority of patients taking a dose of thyroxine that satisfies the recommendations of the American Thyroid Association have no complaints about their medication.”

Not surprisingly, Toft provides no scientific evidence to back up his claim. The reason is that no scientific evidence supports his view. On the contrary, substantial evidence shows that enormous numbers of hypothyroid patients are disappointed with their T4 replacement therapy.

We receive thousands of requests for information through our website question-and-answer service at <www.drlowe.com>. One of the most common questions we receive comes from hypothyroid patients being treated with T4 replacement therapy. Why, they ask, do I still suffer terribly from hypothyroid symptoms? Our answer is that T4-replacement is the least effective approach to thyroid hormone therapy.

Over the past fifteen years, we have carefully evaluated the relative effectiveness of different types of thyroid hormone. Our evaluations have led us to a firm conclusion about T4-replacement: It enables some patients to recover from their hypothyroid symptoms. For most, however, it provides modest improvement at best. Many patients don’t benefit from it at all no matter how high they raise their dose of T4.

Toft’s opinion is contradicted by the popularity of websites that provide information on alternative approaches to thyroid hormone therapy. During 2002-2003, we’ve had an average of 22,000 visitors to <www.drlowe.com> each month, most of whom are hypothyroid patients dissatisfied with the kind of thyroid hormone therapy Toft advocates. Other popular websites are Mary Shomon’s thyroid information site and Thyroid-UK.

Totaled, hundreds of thousands of dissatisfied patients visit these sites and others, looking for information with which they can recover the health they’ve lost through T4 -replacement therapy.

Studies also contradict Toft’s opinion. The Thyroid Foundation of America conducted a survey of patients whose thyroid glands had been removed. The majority were dissatisfied with their treatment.

Also, in 2003, thyroid patient advocate Mary Shomon conducted a survey of more than 850 patients. Over half were dissatisfied with their thyroid hormone therapy. Results of the survey showed that many thyroid patients still suffer from symptoms even though they’re being treated with thyroid hormone. Table 1 gives the percentages of current symptoms reported by the thyroid patients who responded to Mary’s survey.

SAFELY GETTING WELL WITH THYROID HORMONE

Table 1.

Percentage of 860 hypothyroid patients with various symptoms despite treatment

Symptom Percentage still suffering from

• Fatigue 92%

• Inability to lose weight despite diet/exercise 65%

• Feel sluggish & lethargic 62%

• Trouble concentrating 60%

• No sex drive 58%

• Pains, aches, stiffness 51%

• Depression 45%

• Hair loss 43%

• Eyes dry & light sensitive 38%

• Strange feeling in neck or throat 38%

Interestingly, Dr. Toft has waffled in his viewpoint. At the 21st Joint Meeting of the British Endocrine Societies, April 2002, he made a concession that many thought they would never hear from him.

He cited studies showing that restoring normal levels of thyroid hormone in the cells of hypothyroid rats is possible only when they’re treated with a combination of T3 and T4. He then noted a study in which the use of both T3 and T4 by human patients was superior to that of T4 alone. The patients’ cognitive function was better when they used both hormones.

"It would appear,” he then stated, “that the treatment of hypothyroidism is about to come full circle.” By this, Toft meant that the use of T3 and T4 in combination—as was used throughout most of the 20th century—is the superior therapy.

Then, on August 14, 2002, he contradicted his recent public statements. On that date, he wrote a letter replying to thyroid patient advocate Linda Thipthor in Cornwall, UK. “I would reiterate,” he wrote, “that the overwhelming majority of patients feel perfectly well taking Thyroxine [sic] alone in a dose that restores serum TSH to normal.”

The absurdity of this view is obvious from the percentages in Table 1.

Rather than being satisfied with T4-replacement, as Toft claims,thousands of hypothyroid patients are highly dissatisfied with their continuing hypothyroid symptoms. Many are outraged at endocrinologists’ arrogant dismissal of their continuing symptoms as features of mysterious “new diseases” such as fibromyalgia, chronic fatigue syndrome, or myalgic encephalomyelitis (ME). And some patients, although relieved when they promptly recover their health with the thyroid hormone therapy we describe in this chapter, are furious that conventional therapy kept them sick for so long.

TWO MAJOR SOURCES OF UNDER-REGULATION BY THYROID HORMONE Under-regulation by thyroid hormone results from one or both of two disorders: hypothyroidism and partial cellular resistance to thyroid hormone.

He did change his mind about T3 but believe he reversed his opinion.I did a post earlier today. Extracts:

Anthony Toft. In 1999, he wrote of the use of T4 alone, “It shouldnot be forgotten that the majority of patients taking a dose of thyroxine that satisfies the recommendations of the American Thyroid Association have no complaints about their medication.”

and

Not surprisingly, Toft provides no scientific evidence to back up his claim. The reason is that no scientific evidence supports his view. On the contrary, substantial evidence shows that enormousnumbers of hypothyroid patients are disappointed with their T4 replacement therapy

and

Interestingly, Dr. Toft has waffled in his viewpoint. At the 21st Joint Meeting of the British Endocrine Societies, April 2002, he made a concession that many thought they would never hear from him. He cited studies showing that restoring normal levels of thyroid hormone in the cells of hypothyroid rats is possible only when they’re treated with a combination of T3 and T4. He then noted a study in which the use of both T3 and T4 by human patients was superior to that of T4 alone. The patients’ cognitive function was better when they used both hormones.

“It would appear,” he then stated, “that the treatment of hypothyroidism is about to come full circle.” By this, Toft meant that the use of T3 and T4 in combination—as was used throughout most of the 20th century—is the superior therapy.

Then, on August 14, 2002, he contradicted his recent public statements. On that date, he wrote a letter replying to thyroid patient advocate Linda Thipthorp in Cornwall, UK. “I would reiterate,” he wrote, “that the overwhelming majority of patients feel perfectly well taking Thyroxine [sic] alone in a dose that restoresserum TSH to normal.”

The absurdity of this view is obvious from the percentages in Table 1.

Thank You once again for highlighting, these idiots' who play god with our health, the lady endo i used to see has now left the hospital where i go now there is another male doctor,

who like the first endo i ever saw [also male] is trying to get me off t3 and back on t4 only. i have seen him only once but knew straight away he was a d--- head ,i dread my next appointment with him it leaves me physically weak its' like going into battle, even my husband jokes' before i go in ding ding round 2 it should not be this way, he used every scare tactic he could did i know the harm i was doing to myself taking t3 only, ? i replied yes thank you, but not as much damage your colleagues did putting, me on t4 the same thing you yourself are advocating now, i told him i did not want to be kept ill by the nhs neither did i want to miss out on so many things' as i did in the, bad old days' next appointment i think i will do a rap version of my monologue,

or maybe a poem or, maybe just tell him to grow a set stop following the other, sheep and do what he was trained for to help people and above all listen, joking aside whats' really frustrating is he is only young to have a closed mind esp for a doctor is a disgrace he will be treating patients' probably for the next 30 years [god help them].

You can also say that you understand that he is following the guidelines, but guidelines are only good for those happy on levothyroxine, not for the 40,000+ on Healthunlocked Thyroiduk.org.uk who is the NHS Choices for information on dysfunctions of the Thyroid Gland and people are desperate for knowledge/help and miserable through being so unwell.

You can say to him. I am living in my body and you're not. I know that T3 is perfectly safe and makes me feel reasonably well and if I took T3 only I'd may be back to normal health altogether.

Ask him if he ever checks any patient's Free T3 level. Did he know that it is T3 that is the ONLY active hormone required in our receptor cells. If we don't have sufficient, either converting from T4, and/or the addition of T3 we cannot function and we want a life, not a washed out one.

Also ask him did he know that some people have a gene defect called DIO2 and that those people cannot, whatsoever, convert levothyroxine? What would the prescription be for these people?

You can say that for a Testament that T3 alone works and isn't dangerous is that Dr Lowe (above) himself took 150mcg daily as he had thyroid hormone resistant and was able, due to T3, publish many research articles.