Thyroid patients are wiser!! They now know what thyroid treatment works, and what doesn’t.

And they’ve also noted common issues that they share with a large percentage of each other…one being INFLAMMATION.

Sometimes, thyroid patients don’t even know where the inflammation exists in their body, except that their high ferritin reveals it, or their C-Reactive Protein or ESR (erythrocyte sedimentation rate or sed rate) lab tests reveal it. Other times, it’s obvious by the pain they notice in their bodies.

Some ways to deal with inflammation, especially for Hashimotos patients, is removing gluten from the diet. Others have to ascertain if they have Lyme disease that needs treatment. Some have neither problem, but inflammation exists anyway!

Many thyroid patients take supplements to help lower that inflammation, which range from Astaxanthin to Ginger to NAC to Curcumin/Turmeric…and/or a combination of them all.

Here’s a great article written by Yusuf Saleeby, MD. He happens to also be a contributor to the new STOP THE THYROID MADNESS II book, which you should read, and/or give to someone you love as a Christmas present!!

The following published in May/June 2014 edition American Fitness magazine.

It has been well known and understood for years that inflammation is harmful. Inflammation essentially kills. Well, not right away or in a big flashy way, but it does hurt our chances for a healthy disease-free existence and does shorten our lifespan. Inflammation has been proven to increase your risk for heart disease, heart attacks and strokes.1-3 Inflammation is also known to increase a person’s risk for cancer.4,5 It is also linked to obesity and metabolic syndrome; even implicated in Parkinson’s and Alzheimer’s Disease.6-8,9-12

In 2011, researchers at Ohio State University found a link between inflammation and a molecule called microRNA-155 (miR-155). What they discovered was in chronic inflammatory conditions, levels of miR-155 rise and this molecule stimulates and allows for spontaneous mutations of cells contributing to tumorigenesis, the mechanism whereby normal cells become cancerous cells.13-16 While cancers are devastating diseases, all deaths due to cancer do not even come close to numbers of Americans who succumb to heart disease and stroke. So for the purpose of this article we will focus on how inflammation is a big silent killer regarding our hearts and brains; our attention will be on cardiovascular and cerebrovascular disease.

To put it simply, inflammation causes undesirable reactions on the inner lining of blood vessels. The combination of inflammation and circulating lipids is a dangerous recipe that produces something called “foam cells”. Foam cells attach to the endothelial lining of our blood vessels, such as the arteries that feed our heart and brain, and once they mature over months to years form arterial plaques. These plaques narrow the blood vessels making it an eventual challenge for oxygen carrying blood cells to pass. Distal tissues to these narrowing arteries are the ones that suffer. When cells do not get the oxygen they need the result is tissue necrosis in the form of a heart attack or a stroke. Another pathogenesis of inflammation is its impact on maturing plaques. It just happens that inflammation can cause, in a rather short time frame, the rupture of these vessel plaques. In doing so, that plaque can quickly obstruct all blood flow quite abruptly and results in significant damage downstream. One of the biomarkers we shall discuss is FDA-cleared for assessment of plaque rupture and risk of stroke.16 Specific clinically available inflammatory markers are now available for the diagnosis and management of chronic inflammatory states which can impact life and health.

With the recent availability of advanced laboratory testing with a number of inflammatory biomarkers, the clinician has the obligation of identifying inflammation and stomp it out before it puts patients at risk for some ugly disease processes. Identifying overt acute inflammation is as easy as feeling a hot knee joint for example, or identifying fever, stiffness, swelling or pain. Measuring it or quantifying it has typically been with the use of the time tested but non-specific erythrocyte sedimentation rate (ESR) and more recently the C-reactive protein (CRP) tests. However, newer, more specific and diagnostically advanced biomarkers of inflammation have arrived on the playing field to help doctors assess and gauge inflammation. They are sensitive enough to pick up harmful levels of inflammation that may go unnoticed to the casual observer (both patient and doctor). Once identified, the measured inflammation can be watched and carefully reduced by prescriptive medications (statin drugs or anti-inflammatory agents as an example), orthomolecular therapies such as glutathione (NAC), resveratrol or turmeric, and lifestyle modifications (smoke cessation, exercise and weight loss).17,18 Reassessing these inflammatory biomarkers allows clinicians to better guide their patients and assure the reduction of this disease causing entity. This article will discuss a few of these cutting edge inflammatory biomarkers that are currently being used in some clinical practices to identify people at risk for heart disease, stroke, neurodegenerative disorders and diabetes. There are other biomarkers available, many used in research and not clinically applicable or practical. At some point in the future they may find clinical application. Scientists are likely to discover even better biomarkers with more specificity and selectivity for certain conditions as research continues in this field. However, for the time being we will examine the PLAC test, the high sensitivity C-Reactive Protein, Fibrinogen, F2-Isoprostanes, Myeloperoxidase, Interleukins 6 & 17a, and Tumor Necrosis Factor-alpha. Preventive medicine physicians are measuring and monitoring these inflammatory markers to reduce the risk of end-organ damage and degenerative disease in their patients.

Lipoprotein-Associated Phospholipase A2 (Lp-PLA2, or PLAC)

The Lp-PLA2 biomarker is an enzyme associated with plaques in the arteries. Carried mostly by LDL-Cholesterol this enzyme in high levels of circulation is found when inflammation is high and plaque rupture in eminent. When levels of this inflammatory marker remain high for long periods of time there is a very high chance for cardiovascular events and risk of ischemic stroke. Prolonged activity of this enzyme is associated with coronary calcification or ‘’hardening of the arteries”. The PLAC test was recently cleared by the FDA to assess the risk of both coronary heart disease and ischemic stroke associated with atherosclerosis.16 Nicotinic acid as well as fenofibrate therapy has effectively treated elevations in Lp-PLA2.19,20

High sensitivity C-Reactive Protein (hs-CRP)

Much like the ESR this biomarker of inflammation is non-specific; it is formed in the liver as a reaction to inflammation occurring in other parts of the body. The high sensitivity CRP is a measure of minuscule amounts of this protein that are typically associated with vascular inflammation. The chronic elevation of this acute phase reactant is used to predict risk of heart attack and undesirable events in those with angina and in those who are having a heart attack. Elevated CRP may be a better predictor of heart disease than elevations in LDL-cholesterol.21 While Lp-PLA2 elevations can double the risk for heart attack and stroke, having both the Lp-PLA2 and hs-CRP elevated increases heart disease four-fold and stroke risk by a factor of ten. This inflammatory protein responds remarkably well to exercise.21

Fibrinogen

Fibrinogen will convert to fibrin as blood clots form. So fibrinogen, a protein, is a good measure of acute inflammation and is associated with risks of heart disease. Elevated fibrinogen can cause platelets to clump together or aggregate, increase the viscosity of blood and embellish other clotting factors. There is a strong correlation between elevated levels of fibrinogen and acute ischemic stroke.22 Fibrinogen is therefore a good tool for evaluation of stroke risk and prediction of a future heart or brain event. To reduce this pro-thrombotic state, a reduction of fibrinogen can be accomplished by routine aerobic exercise, smoke cessation, aspirin therapy and omega-3 fish oil supplementation and increasing endogenous glutathione with N-AcetylCystine (NAC) or bioavailable oral/IV glutathione (S-AcetylGlutathione).23

F2-Isoprostanes (F2-Isops)

While the initial implementation of exercise can often raise the F2-Isops levels, eventually sustained regular exercise lowers it to safer levels. F2-Isoprostanes are prostaglandin like compounds which are formed by the oxidation of free fatty acids by free-radicals in circulation. Poor diets, too rich in red meat, a sedentary lifestyle and cigarette smoking all contribute to the elevation of this inflammatory marker. F2-Isops is a strong predictor of coronary heart disease (CHD) as elevated levels cause oxidative stress on arterial walls and the production of atherosclerotic plaques. These isoprostanes also act as potent vasoconstrictors, which can further limit passage of blood cells through already narrowed arteries. Control of triglycerides (TG), diet and exercise combat this marker. Eicosapentaenoic acid (EPA) and docosapentaenoic acid (DHA) are two omega-3 fatty acids that are generally shown in multiple research studies to lower F2-Isoprostanes.23-26

Myeloperoxidase (MPO)

Particular white blood cells (WBC) called polymorphonuclear leukocytes and monocytes produce an enzyme called myeloperoxidase, this enzyme help your immune system fight infections only when your body uses it correctly. With chronic inflammation there is too much MPO released into circulation from WBCs and this hampers the function and bioavailability of nitric oxide. Nitric oxide (NO) is crucial to proper endothelial function in our arterial walls. MPO also causes the oxidation of HDL-C (good cholesterol) and impairs its ability to pull bad cholesterol (LDL-C) away from arteries for recycling. Additionally, the oxidizing effect of MPO on LDL-C contributes to the formation of foam cells and increases the likelihood of plaque rupture. Elevated levels of MPO in the presence of coronary artery calcium (CAC) raise the risk for a coronary event. Aspirin therapy, statin drug therapy (such as atrovastatin (Lipitor®) for example) and proper diet rich in omega-3 fatty acids (fish oil) all help lower MPO.27 Of all the biomarkers discussed here, probably the most detrimental when found elevated is the MPO. Aggressive measures should be taken to reduce this marker, especially over the long term.

Interleukin-6 (IL-6)

Interleukin-6 (IL-6) is a pro-inflammatory cytokine. Cytokines are proteins that act as cell-signaling molecules in the immune system. IL-6 can increase the aggregation of platelets causing clumping and infarction when blood vessels are narrow and blood flow is impeded. IL-6 augments the synthesis of CRP and is thus associated with increased risk of cardiovascular disease (CVD). Elevated levels of IL-6 are associated with a 2 fold increase in diabetes risk and an even higher (3-fold) risk of CVD. We know the blockade of IL-6-receptors by drugs like tocilizumab (Actemra®) in patients with rheumatoid arthritis is helpful, but whether this drug will have a similar effect on reduction of the ill effects of this circulating inflammatory cytokine on the heart or brain remains to be seen.28

Interleukin-17a (IL-17a)

Another inflammatory cytokine that has a role in vascular remodeling and function is Interleukin-17a. Elevated levels of IL-17a are responsible for vascular dysfunction and are found at increased levels in the presence of unstable angina and heart attacks. However, one study pointed out that low levels of circulating IL-17a in the presence of an acute myocardial infarction (AMI) or heart attack had poor outcomes for survival. While some studies show it as a risk factor in the asymptomatic individual, this may be untrue in the acute setting. More research is needed. Hence, blocking this interleukin too aggressively may have unwanted outcomes.29

Tumor Necrosis Factor-alpha (TNF-α)

A pro-inflammatory cytokine referred to as TNF-α is excreted from macrophages (immune system cells that fight infecting microbes). People with the autoimmune and inflammatory disease systemic lupus erythematosus (SLE) are known to be at higher risk for CVD. There is a correlation between the inflammatory TNF marker which is elevated in SLE patients and their CVD risk. Some researchers are inclined to believe that this is what causes the increased risk of heart attacks in this subset of patients. Elevated levels of this cytokine can have a negative effect on sugar metabolism by interfering with insulin receptors. Elevated TNF-α levels result in a two fold increase in CVD risk. Weight loss and statin drug therapy can lower these levels. Controlling this marker’s levels may also reduce the risk of acquiring diabetes.30

So the take home message here is that chronic inflammation is bad for your health and wellbeing. Even acute bursts of inflammation can significantly raise the risk of an acute event such as a heart attack or stroke. A very good illustration of this is found in a study in Mexico City, where air pollution levels are monitored in one of the most polluted cities in the western hemisphere. There were correlations made with rises in AMIs in a population of nursing home patients on particularly dirty air quality days in that city. The elevated air particle count attributed to an acute increase in inflammatory biomarkers and thus triggered heart attacks.31

Besides the impact on cardiovascular health, inflammation is to be avoided for many other reasons, from neurodegenerative diseases such as Parkinson’s and Alzheimer’s disease to development of cancers to destructive and degenerative diseases of our skeletal system. We are now at the cusp of clinically available, specific biomarkers of inflammation that allow doctors to identify those at risk and diligently (with periodic monitoring of serum and urine levels) evaluate therapy that reduce harmful inflammation.

ABOUT THE AUTHOR:Yusuf (JP) Saleeby, MD is a contributing editor for American Fitness magazine. He practices preventive integrative medicine and age management in Murrells Inlet & Greenville, SC. Dr. Saleeby is regional director of a direct access testing site that offers analysis of inflammatory bio-markers. He can be reached at www.saleeby.net or by e-mail at jpsaleeby@aol.com. You can also see his other website here: http://www.getmythyroidfixed.com/

O’CONNELL, R.M., ET AL. “MICRORNA-155 IS INDUCED DURING THE MACROPHAGE INFLAMMATORY RESPONSE.”PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 104, NO. 5 (JAN 2007): 1604-09.

TILI, E., ET AL. “MUTATOR ACTIVITY INDUCED BY MICRORNA-155 (MIR-155) LINKS INFLAMMATION AND CANCER.”PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 108, NO. 12 (MAR 2011): 4908-13.

John, a variety of reasons. For those with the autoimmune version, inflammation can be caused by the attack on the thyroid, and/or gluten. For those without hashimotos, it can be caused by the immune system dysfunction which undiagnosed or undertreated hypo can cause. Some of what Dr. Saleeby wrote explains it. Or it could be due to other issues that go concurrently with one’s hypothyroidism.

I see my problems in this article and yet cannot get rid of the inflammation. I constantly have low iron but higher than normal looking ferritin as an acute phase reactant along with my other AFRs. At a loss what to do. Will not do statins and I have tried various natural solutions. I am still gluten free. Just hoping LDN might be an answer for me. I have been ill for so many years now and I am housebound except for really occasional necessary outings God bless Janie for your trying to help. I have followed you for years now.
Dawn x

Hi Janie, I’ve been on 2 grains of ndt for about 1 month and still feel so so tired. I’m taking adaptagens for my cortisol but I’ve never been tested. When i take my morning ndt dose I get headaches and sometimes feel nauseous and worse than before. But when i take my afternoon dose I still don’t feel great but not as bad as the morning. Also yesterday i decided to take my ndt at night and i slept like a baby! Why is this? Did not get up once. I was diagnosed with subclinical hypothyroidism a few months back as I had all the symptoms but normal labs which forced me to see a naturopath. The main symptoms are that i have been losing hair since I was about 16 and I’m now 32 and I have been overweight since I was little. My doctor refused to even entertain the idea that my thyroid was out. Also a few days ago I had some more labs done but I had taken my morning dose before getting the labs done and it showed that I was hyper! Iron levels have improved and I’m not anemic anymore, TSH was .01 and free t3 was way over the normal range whilst t4 was high normal yet I’m as tired and overweight as ever. Could you please help me in terms of where do I go from here next and what should I be taking for my adrenals. Also months ago I had a blood test done with showed my hpa axis was out. What can I do for this? Also I’m on lugols as well. I also take magnesium, vitamin c, vitamin d, vitamin b, tyrosine and selenium. Am I on too many things? Nothing seems to be helping and my energy levels are woefully inadequate for my circumstances. I’m married with two very active boys and I work as well. To make matters worse, my husband isn’t that supportive and I feel like running away from everything so that I could just sleep all day and not have anyone bother me ever. Any advice you have would be very very much appreciated. Thank you. P.S. I live in Australia.

So pleased I came across this. I have hypothyroidism and an auto immune thing attacked my liver. I now have giant cell arteritis for which I take steroids. Weight is a great problem for me and due to pain in my bones restricts exercise. After reading this article I will try harder.

This is a wonderful article! I have been plagued with sinus inflammation all my life and have never been able to get ride of the inflammation in my nose and throat. In the last three month, my glands are always swollen, especially upon rising in the morning–I look like I have the mumps! I have TPO antibodies, so probably have Hashimoto’s. Am having problems with pooling, low T3 (4.1) and high RT3 (28), ratio = 14… My NP feels I have metabolic syndrome and I’ve tested “severe insulin resistant”. NDT 3 gr. and iodine protocol (25 mg) are not doing the trick. Can you offer any advice? Thank you for your time.

Hi Janie
My daughter has just been diagnosed with hypomania. I have asked her doctor to please test her for thyroid issues but she is very reluctant even though she has so many symptoms and i suspect has been swinging between hyper and hypo for some time. I also think her adrenals are severely stressed. She has a10 week-old baby and so the hospital is treating her at home. I want to make another attempt to get her thoroughly tested. Can you please tell me what tests i should ask for?
thank you so much!

Help would be great… Ok here goes, I’m 44 a Gulf war veteran with joint problems PTSD and diagnosed thyroid disorder Hypo? (2013) I take meds levothyroxizine for thyroid through my local VA clinic. My doctor doesn’t tell too much info… according to her 3 weeks ago I’m healthy but she says I’m overweight (240) 6 months ago I was 225. What do Thyroid problems do to you? Dry hands, dry heels, I only eat a few times a day. Body always hurts and can’t raise my left arm above my shoulder for more than 20 min. without it shaking and loose feeling/tingle. There are more but don’t want to rant. Fill me in if you can

Hi William. Thyroid problems slow down the metabolism for a large body of us, causing easy weight gain. Hypo also causes dry hands, heels, as well as body pain, the latter which the doctor will call “Fibromyalgia” as if it’s separate from being hypo, but for us, it isn’t separate. It’s what hypo can do to us. Your PTSD could be the cause of the hypo, we’ve discovered, since either high or low cortisol can make it hard for thyroid hormones to get to the cells. PTSD can also cause you to produce too much Reverse T3–an inactive thyroid hormone. http://www.stopthethyroidmadness.com/reverse-t3 Patients will get the RT3 with a FT3 and see what the ratio is.

Patients in your shoes order and do the 24 hour adrenal saliva test to see exactly what is going on with the adrenals. You can order one from here: http://www.stopthethyroidmadness.com/recommended-labwork. Once you get the results back, compare them to the link mentioned at the bottom of that page. The VA is pretty backwards about all this.

And finally, it’s Natural Desiccated Thyroid which patients have found to do a FAR better job treating hypothyroidism than levothyroxine. Read these:

Has anyone ever looked into the “Forks Over Knives”movement. It promotes not eating any animal protein. Suggesting that eating animal protein and especially milk, causes cholesterol in our bodies which then leads to inflammation and then to disease. A lot of their research is very interesting.

I have had major inflammation for 3.5 years. My doctor put me on 400 mg Spironolactone a little over a year ago but it only helped by maybe 50%. I have been on Armour 180 for 2.5 years and until the buyout by Actavis I was doing well considering I have Hashimoto’s, but since I received my latest prescription of Armour, labeled as Actavis not Forrest, I am now feeling like I am not on any thyroid meds at all. This of course means that my inflammation is rising more and more and since diet restriction for 18 months did not help me, I am getting overwhelmed and I am not sure where to turn. This morning my feet, legs, and hands are so swollen I can barely type. I have been stressing to my doctor for years that the Spironolactone(Aldactone) is as bad as the inflammation. Now thanks to Actavis changing my Armour I am all the way back to square one. I looked into Westhroid but the fillers concern me, I have talked with doctor about LDN but she has never responded. I am lost and hopeless….I did everything I was supposed to, an advocate for my own health, thousands of hours spent in 4 years, many trees dead from coping my research for my doctor, but non of it matters when the doctors just don’t care. It is time I give up the fight since I cannot write my own prescriptions, there is nothing more that I can do.

im on Armour I been on it for about 3 yrs on low dose. Then suddenly last may I noticed a drastic change in my health & began to have extreme wt gain 35 lbs, ( over 6-8 mon), bad hair loss, memory loss etc etc worsen & confines even on 120 mg before next visit. HELP. Is this due to a change in Armour Forrester to another company formula!!?? Im slowly getting worse, most labs for hypo normal except TSH 5.4 now in Jan ’15, but was suddenly 16.9 in June 2014! Im dying again as did many years go when DX with Hypo! Im in late 50s.

Two years ago I was having chest pains and my primary referred me to a cardiologist. My cardiologist performed blood tests including myexeloperioxidase (MPI). He called right away when he got the results back. MY MPO level was 3600!!! I don’t know the unit of measure but 400 was considered “Very High” and neither he nor his colleagues had ever seen an MPO level approaching my level. I was immediately put on blood thinner and further testing including an angiogram showed a 30% blockade of LDA. Cardiologist also suggested follow up with a blood cancer/disorder specialist – fortunately those tests came back “normal.” Two years later and my MPO has decreased to 2500 but this is still 6X above very high levels. My other issues – weight, apnea, gout, depression and family
history has me thinking that something else is off – I think thyroid. This is the first article I have found that speaks of a link between inflammation, MPO and thyroid. Thank you – it supports my drive to find out what may really be going on with me!

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Thyroid Madness Definition according to many reported patient experiences:

Treating most hypothyroid patients with T4-only meds; offering no options.

Dosing solely by the TSH and the total T4, or using the outdated "Thyroid Panel".

Prescribing anti-depressants in lieu of evaluating and treating the free T3.

Doctors will have more lives to answer for in the next world than even we generals. ~Napoleon Bonaparte Is it possible that what was already awful....can be MORE awful?? Apparently so in the UK (United Kingdom). If…