Real Niacin provides niacin in an 8-hour extended-release form that enables you to enjoy the health benefits of niacin without experiencing the uncomfortable skin flushing that commonly accompanies other forms of niacin. Niacin comprises approximately 200 coenzymes that play pivotal roles in metabolism and energy production within the body. Additionally, research suggests that niacin, in combination with a well-balanced diet, may help to maintain healthy cholesterol levels that are already within the normal range.

Science-based nutrition

Promotes cardiovascular health

8-hour extended-release

No/low flush

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Supports cardiovascular healthExtensive clinical research has shown that niacin as nicotinic acid may promote a favorable balance of blood lipids. The form of niacin typically found in multivitamins and fortified foods is “nicotinamide,” which exhibits vitamin B3 activity but not necessarily the cardiovascular benefits seen in research that examined nicotinic acid. According to a report endorsed by the American Heart Association, nicotinic acid appears capable of modulating blood lipids in part by altering their synthesis and inhibiting the mobilization of free fatty acids. Two niacin receptors, HM74 & HM74A, were recently discovered in humans. The HM74A receptors on adipose (fat) cells are believed to be particularly responsible for the helpful blood lipid-altering ability of nicotinic acid.

Extended-release formula decreases chance of “Skin Flushing”Real Niacin provides an 8-hour extended-release tablet that enables more people to access the health-supportive aspects of niacin with less chance of experiencing the uncomfortable skin flushing that commonly accompanies the unspecialized niacin in immediate-release (IR) forms of the vitamin. Release of the eicosanoid prostaglandin D2 from skin cells is believed to be behind the skin flushing that may occur with niacin use. This “prickly heat” phenomenon results in a sensation of warmth, reddening, and/or tingling anywhere from 15 to 120 minutes after consumption of a large dose, often felt on the head, neck, and shoulders for up to an hour. Although flushing is a non-allergic reaction producing no permanent harm to the body, it is the major reason for discontinued use of niacin—thereby preventing many individuals from experiencing the potential benefits of supplementation. When taken as directed, extended-release formulas similar to Real Niacin have been shown to decrease the potential of flushing.

Supports the maintenance of cognitive function with ageDiets high in niacin have been associated with healthy cognitive function in the aging mind. This may in part be a result of niacin’s direct role in the regulation of healthy dendritic growth; dendrites are a class of neuronal cells that enable the brain to communicate electric signals to other parts of the brain and the body. Niacin is able to provide potent antioxidant activity to address the accumulation of free radicals in brain mitochondria, the powerhouse organelles within neurons. Niacin is important for many of the complex regulatory pathways utilized by the body to maintain health with age.

The possible associations between niacin intake and the maintenance of healthy cognitive function with age were investigated through the examination of data from the massive Chicago Health and Aging Project (CHAD). The cognitive function in 3718 CHAD participants was assessed by four tests designed to measure mental attributes such as short and long term memory, intellectual ability, and motor control. Among the elderly participants who remained in good health during the 6-year study period, cognitive function was maintained at a 44% greater rate in individuals who had the highest dietary intake of niacin compared to those who consumed the lowest amount of niacin.

Supports healthy metabolism and energy production within the bodyNiacin – in both its nicotinic acid and nicotinamide forms – is well absorbed and can act as a biochemical precursor to nicotinamide adenine dinucleotide (NAD+) and sister coenzyme nicotinamide adenine dinucleotide phosphate (NADP+). The two molecules NAD+ and NADP+ are involved in more than 500 enzymatic reactions and are especially important in metabolism and energy production. All of the human body’s cellular energy is synthesized through mitochondrial oxidative phosphorylation, the citric acid cycle, and cytosolic glycolysis: these pathways all require an adequate supply of NAD+ and NADP+. Real Niacin supplies nicotinic acid in an extended release form that supports healthy metabolism and energy production throughout the day by helping to provide the body with an abundant pool of NAD+ and NADP+.

Doctor's BestDoctor's Best firmly believes in the integration of science research and traditional wisdom as the way that nutritional and herbal supplements will reach their exciting potential. Founded in 1990 by a pioneering physician committed to science-based alternative health care, Doctor’s Best offers only the most important nutritional supplements. Careful research and precise formula development keeps us at the leading edge of quality, effectiveness, and innovation.

Containing the finest quality raw materials from around the world, Doctor’s Best supplements embody the best that traditional knowledge and current scientific research have to offer in the field of therapeutic nutrition. Countless hours have been spent analyzing scientific literature to provide sound alternatives to the proliferation of questionable supplements in the marketplace.

Warnings

Temporary flushing, itching or warming of the skin may occur upon initial use. If you are under medical supervision, have liver dysfunction, gout, or are pregnant or nursing, consult your physician before taking this product.

Manufacturer Info

About Doctor's Best

Founded in 1990 by a pioneering physician committed to science-based alternative health care, Doctor’s Best offers only the most important nutritional supplements. Containing the finest quality raw materials from around the world, Doctor’s Best supplements embody the best that traditional knowledge and current scientific research have to offer in the field of therapeutic nutrition. Each of their products is accompanied by an annotated "fact sheet" with detailed background information, structure-function statements, and scientific references that substantiate these statements. All structure-function statements have been filed with FDA in accordance with DSHEA regulations.

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