Leukocyte adhesion deficiency, type III

Common Name(s)

Leukocyte adhesion deficiency, type III

Leukocyte adhesion deficiency-3 (LAD3), also known as LAD1 variant (LAD1V), is an autosomal recessive disorder characterized by LAD1 ({116920})-like immune deficiency and Glanzmann thrombasthenia (GT; {273800})-like bleeding problems. LAD3 results from mutations in FERMT3, or KINDLIN3, which encodes an intracellular protein that interacts with beta-integrins in hematopoietic cells. In LAD3, the adhesive functions of integrins on both leukocytes and platelets are disrupted, most likely due to defects in activation-dependent alterations of surface integrins that enable high-avidity binding to ligands on target cells, a process termed 'inside-out signaling' ({12:Svensson et al., 2009}; {13:Zimmerman, 2009}).

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Finding the right clinical trial for Leukocyte adhesion deficiency, type III can be challenging. However, with TrialsFinder (which uses the Reg4ALL database and privacy controls by Private Access), you can permit researchers to let you know opportunities to consider - all without revealing your identity.