Taliglucerase alfa

Taliglucerase alfa treats Gaucher disease. It can cause side effects during and after the infusion.

Taliglucerase alfa Overview

Updated: February 19, 2016

Taliglucerase alfa is a prescription medication used to treat Gaucher disease. Taliglucerase alfa belongs to a group of drugs called enzymes. These work by acting like the enzyme glucocerebrosidase. This enzyme does not work well in people with Gaucher disease.

This medication is available in an injectable form to be given directly into a vein (IV) by a healthcare professional.

Common side effects of taliglucerase alfa include headache, joint pain, and lack of energy.

Taliglucerase alfa can also cause dizziness. Do not drive or operate heavy machinery until you know how taliglucerase alfa affects you.

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Taliglucerase alfa Interactions

No drug interactions have been reported by the manufacturer. However, you should tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements. Not all drug interactions are known or reported and new drug interactions are continually being reported.

Taliglucerase alfa Precautions

Serious side effects have been reported with taliglucerase alfa including the following:

Allergic Reactions (Hypersensitivity reactions including anaphylaxis). Serious hypersensitivity or allergic reactions have occurred in some patients treated with taliglucerase alfa. Your doctor should monitor you for reactions before, during, and after you receive taliglucerase alfa. These reactions can occur up to 3 hours after receiving the infusion. Tell your doctor immediately if you experience any of the following signs or symptoms:

hives (red itchy welts)

low blood pressure

wheezing

chest tightness

nausea or vomiting

dizziness

rash

sudden cough

irritated throat

flushing (turning red in the face or other areas of the skin)

If you experience any of these symptoms, your doctor may slow your infusion or stop it altogether. Your doctor may give you certain medications before receiving taliglucerase alfa to help prevent any infusion reactions.

Taliglucerase alfa can cause drowsiness. Do not drive or operate heavy machinery until you know how this medication affects you.

Do not receive taliglucerase alfa if you are allergic to taliglucerase alfa or to any of its ingredients.

Taliglucerase alfa Food Interactions

Medications can interact with certain foods. In some cases, this may be harmful and your doctor may advise you to avoid certain foods. In the case of taliglucerase alfa, there are no specific foods that you must exclude from your diet when receiving this medication.

Taliglucerase alfa and Pregnancy

The data on taliglucerase alfa use in pregnant women is not enough to inform a drug-associated risk. In animal studies, pregnant animals were given taliglucerase alfa and the babies did not show any medical issues related to this medication.

Women with Type 1 Gaucher disease have an increased risk of serious complications with pregnancy if the disease is not adequately controlled before and during pregnancy. Becoming pregnant can also worsen the symptoms of Type 1 Gaucher disease.

You and your doctor should discuss the risks and benefits of receiving taliglucerase alfa while pregnant or when you are planning to become pregnant.

Taliglucerase alfa and Lactation

It is not known if taliglucerase alfa crosses into human milk. Because many medications can cross into human milk and because of the possibility for serious adverse reactions in nursing infants with use of this medication, a choice should be made whether to stop nursing or stop the use of this medication. Your doctor and you will decide if the benefits outweigh the risk of using taliglucerase alfa.

Taliglucerase alfa Usage

Taliglucerase alfa comes in an injectable form to be given directly into a vein (IV) by a healthcare professional, once every other week. Taliglucerase alfa infusions should take 1 to 2 hours to complete.

It is important to keep all of your appointments to receive doses of taliglucerase alfa. If you miss an appointment to receive a dose, contact your healthcare provider immediately.

Taliglucerase alfa Dosage

The dose of Elelyso your doctor recommends may be based on the following:

your weight

if you are currently being treated with imiglucerase (a different medication for Type 1 Gaucher disease)

how you respond to this medication

The recommended dose of Elelyso (taliglucerase alfa) for patients who are not currently receiving any treatment for Type 1 Gaucher disease is 60 units per kg of body weight, given once every other week.

If you are switching from imiglucerase (Cerezyme) to Elelyso (taliglucerase alfa), you will receive the same dose of Elelyso that you were receiving of Cerezyme, once every other week.

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