Numerous single studies indicate a correlation between a given SNP and migraines, but subsequent studies, whether of different populations, larger patient numbers, or via pooled meta-analyses, have often failed to replicate the initial findings. Caveat emptor!

Drugs used to treat migraines may also be more or less successful based on a patient's genotype, since SNPs in a variety of genes affect the metabolism of these drugs. Some of the classes of drugs that have been used to treat migraines include the following: