Choline on the Brain? A Guide to Choline in Chronic Fatigue Syndromehttp://phoenixrising.me/research-2/the-brain-in-chronic-fatigue-syndrome-mecfs/choline-on-the-brain-a-guide-to-choline-in-chronic-fatigue-syndrome-by-cort-johnson-aug-2005
Discuss the article on the Forums.

New paper: Deviant Cellular and Physiological Responses to Exercise in ME

Post-exertional “malaise” is a hallmark symptom of Myalgic Encephalomyelitis (ME) and Chronic Fatigue Syndrome (CFS). Various abnormalities, including abnormal physiological responses to exertion, can account for post-exertional “malaise” and “exercise avoidance”. Since these abnormalities are not observed in sedentary healthy controls, the abnormalities and deviant responses cannot be explained by “exercise avoidance” and subsequent deconditioning, nor by psychogenic factors. Keywords: Myalgic Encephalomyelitis; Chronic Fatigue Syndrome; Exercise Physiology; Energetics; Immune System; Oxidative And Nitrosative Stress Review Article Cite this article: Twisk and Geraghty. Deviant Cellular and Physiological Responses to Exercise in Myalgic Encephalomyelitis and Chronic Fatigue Syndrome. J J Physiology. 2015, 1(2): 007. Introduction Post-exertional “malaise”, a (prolonged) aggravation of symptoms after a minor exertion, is a discriminative symptom of Myalgic Encephalomyelitis (ME) [1-3] / Chronic Fatigue Syndrome (CFS) [4]. Several abnormalities observed in ME/CFS, such as a prolonged fall in oxygen uptake after exercise, and a post-exertional increase in metabolite-detecting (pain) receptors [5], can plausibly account for “exercise intolerance” reported by ME/CFS patients and the lack of the success of rehabilitation protocols. Since these abnormalities are not observed in sedentary controls, deconditioning (alone) cannot account for the physiological aberrations in ME/CFS after exertion. The exercise-induced abnormalities, which cannot be explained by psychogenic factors, appear strong correlates of ME/CFS. Abnormalities relating to exercise and its effect

Click to expand...

Conclusion

Post-exertional “malaise” and “exercise intolerance” are hallmark symptoms [80] of Myalgic Encephalomyelitis (ME) [1-3] and Chronic Fatigue Syndrome (CFS) [4]. This article reviews observations which support the position that post-exertional “malaise” in ME/CFS may be linked to a number of observable deviant physiological responses to exercise, including muscle weakness and myalgia, a substantial fall of oxygen uptake after exercise, an increase in metabolite-detecting (pain) receptors, increased acidosis, abnormal immune responses, and orthostatic intolerance. Such findings go some way to explain why many ME/CFS sufferers either avoid exercise or report negative effects of exercised-based rehabilitation protocols, such as graded exercise therapy (GET). The physiological abnormalities induced by ME/CFS cannot be simply explained by a sedentary life style and deconditioning [81], or psychogenic factors [82]. While we acknowledge the importance of physical activity in illness rehabilitation, our findings cast doubt on the efficacy of exercise protocols as a therapeutic approach. More research into exercise-induced cellular and physiological abnormalities in ME/CFS is needed to better understanding the illness and its impact on patients, and to develop appropriate treatment.

aberrant would have been a possible alterntive adjective for our paper title, however given its use in 'psychosomatic studies' relating to aberrant thought processes, we felt it better to use deviant physiological responses.

we are working on a longer and more detailed paper, and hope to test some of our hypotheses in forthcoming work in this area.

The current paper includes some interesting observations regarding responses in ME/CFS following exercise.

Post-exertional “malaise” is a hallmark symptom of Myalgic Encephalomyelitis (ME) and Chronic Fatigue Syndrome (CFS). Various abnormalities, including abnormal physiological responses to exertion, can account for post-exertional “malaise” and “exercise avoidance”. Since these abnormalities are not observed in sedentary healthy controls, the abnormalities and deviant responses cannot be explained by “exercise avoidance” and subsequent deconditioning, nor by psychogenic factors.

Post-exertional “malaise” and “exercise intolerance” are hallmark symptoms [80] of Myalgic Encephalomyelitis (ME) [1-3] and Chronic Fatigue Syndrome (CFS) [4]. This article reviews observations which support the position that post-exertional “malaise” in ME/CFS may be linked to a number of observable deviant physiological responses to exercise, including muscle weakness and myalgia, a substantial fall of oxygen uptake after exercise, an increase in metabolite-detecting (pain) receptors, increased acidosis, abnormal immune responses, and orthostatic intolerance. Such findings go some way to explain why many ME/CFS sufferers either avoid exercise or report negative effects of exercised-based rehabilitation protocols, such as graded exercise therapy (GET). graded exercise therapy (GET). The physiological abnormalities induced by ME/CFS cannot be simply explained by a sedentary life style and deconditioning [81], or psychogenic factors [82]. While we acknowledge the importance of physical activity in illness rehabilitation, our findings cast doubt on the efficacy of exercise protocols as a therapeutic approach. More research into exercise-induced cellular and physiological abnormalities in ME/CFS is needed to better understanding the illness and its impact on patients, and to develop appropriate treatments."

Your review is most timely for me, as just yesterday I had a first appointment with a new primary care physician, Even after she observed impaired circulation in my feet and hands, and I described how my pulse goes from 60 supine to 120 standing within 10 minutes (when I'm not taking atenolol), she concluded that my illness is "mostly psychological".

I think your article is just about the right length to show to a busy physician and I will do that promptly.