In the current study, the investigator used a triple-transgenic mouse model that grows plaques and tangles in the brain similar to human AD. Four cohorts of between 15 and 24 mice each were injected in the skin with DNA coding for the Abeta42 peptide. The researchers had already shown that full-length DNA Abeta42 trimer immunization was non-inflammatory and influence a regulatory immune response. Immunotherapy with DNA Abeta42 trimer led to the reduction of Abeta40/Abeta42 peptides and amyloid plaques and led significant reduction of tau from the brains of the mice. “If the onset of the disease could be delayed by even five years that would be enormous for the patients and their families,” said senior author Dr. Doris Lambracht-Washington, assistant professor of neurology and neurotherapeutics at the University of Texas Southwestern Medical Center.
Original Link: https://www.biotechdaily.com/genomics-proteomics/articles/294775977/novel-dna-vaccine-prevents-ad-in-mouse-model.html

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