The Harvard Digestive Disease Center (HDDC) is a NIH-funded community of scientists focused on the study of epithelial cell function and mucosal biology including inflammation and host defense of the gastrointestinal tract.

We have a major focus on the intestinal and inflammatory bowel diseases; gut microbiology; and stem cell and developmental biology of the intestine and liver in organ physiology, regenerative medicine, and metabolism.

Center member’s research address three major themes that are basic to understanding the mechanisms of normal digestive tract function and the pathogenesis of disease: