IgG from atopic dermatitis patients induces IL‐17 and IL‐10 production in infant intrathymic...
Sgnotto, Fábio D. R.; Oliveira, Marilia G.; Lira, Aline A. L.; Inoue, Amanda H. S.; Titz, Tiago O.; Orfali, Raquel L.; Bento‐de‐Souza, Luciana; Sato, Maria N.; Aoki, Valeria; Duarte, Alberto J. S.; Victor, Jefferson R.
2018-01-01 00:00:00
IntroductionIn the last 15 years, our group has investigated adoptive maternal–fetal immune interactions in the context of allergy regulation. In 2014, the authors suggested that maternal immunization could influence intrathymic maturation of lymphocytes on offspring. Two years later, we proposed a hypothesis named “MatIgG primary modulation theory” that questioned whether IgG could directly influence the maturation of lymphocytes on primary organs such as thymus and bone marrow.The potential of IgG antibodies as regulators of the immune response has been discussed for decades. More than 20 years ago, evidence that maternal IgG suppresses offspring IgE production was obtained in a murine model. In the following decades, further proof connecting maternal IgG to children allergy inhibition was published, including evidence that murine passive transfer of IgG can modulate the offspring B‐cell phenotype.Recently, our group demonstrated that human purified IgG from atopic individuals influences the cytokine production profile of human intrathymic αβT cells in vitro; moreover, such an influence of IgG upon lymphocytes during the maturation process was not entirely dependent on the maternal origin of IgG. Our next step was to evaluate whether the IgG repertoire from AD patients correlates with cytokine modulation, thus favoring eczematous lesions.Recently, Batista and colleagues demonstrated
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Abstract

IntroductionIn the last 15 years, our group has investigated adoptive maternal–fetal immune interactions in the context of allergy regulation. In 2014, the authors suggested that maternal immunization could influence intrathymic maturation of lymphocytes on offspring. Two years later, we proposed a hypothesis named “MatIgG primary modulation theory” that questioned whether IgG could directly influence the maturation of lymphocytes on primary organs such as thymus and bone marrow.The potential of IgG antibodies as regulators of the immune response has been discussed for decades. More than 20 years ago, evidence that maternal IgG suppresses offspring IgE production was obtained in a murine model. In the following decades, further proof connecting maternal IgG to children allergy inhibition was published, including evidence that murine passive transfer of IgG can modulate the offspring B‐cell phenotype.Recently, our group demonstrated that human purified IgG from atopic individuals influences the cytokine production profile of human intrathymic αβT cells in vitro; moreover, such an influence of IgG upon lymphocytes during the maturation process was not entirely dependent on the maternal origin of IgG. Our next step was to evaluate whether the IgG repertoire from AD patients correlates with cytokine modulation, thus favoring eczematous lesions.Recently, Batista and colleagues demonstrated