beta-arrestin-1 is an adaptor protein that mediates agonist-dependent internalization
and desensitization of G-protein-coupled receptors (GPCRs) and also participates in
the process of heterologous desensitization between ...

Exogenous gene delivery to alter the function of the heart is a potential novel therapeutic
strategy for treatment of cardiovascular diseases such as heart failure (HF). Before
gene therapy approaches to alter cardiac function ...

BACKGROUND: Stimulation of beta(1)- and beta(2)-adrenergic receptors (ARs) in the
heart results in positive inotropy. In contrast, it has been reported that the beta(3)AR
is also expressed in the human heart and that its ...

Deleterious effects on the heart from chronic stimulation of beta-adrenergic receptors
(betaARs), members of the 7 transmembrane receptor family, have classically been shown
to result from Gs-dependent adenylyl ...

Our laboratory has been testing the hypothesis that genetic modulation of the beta-adrenergic
signaling cascade can enhance cardiac function. We have previously shown that transgenic
mice with cardiac overexpression of either ...

When the heart fails, there is often a constellation of biochemical alterations of
the beta-adrenergic receptor (betaAR) signaling system, leading to the loss of cardiac
inotropic reserve. betaAR down-regulation and functional ...