Tournament director Bill Oakes announced today that his two star attractions, top seed Tomas Berdych and local favorite John Isner, have withdrawn from the Winston-Salem Open in North Carolina.

Berdych cited shoulder pain while Isner, a finalist in Cincinnati on Sunday, said he had a hip issue.

“It is really unfortunate I have to withdraw from the Winston-Salem Open, one of my favorite tournaments of the year,” said Isner who grew up near the tournament in Greensboro. “I’ve had so much success playing in front of great crowds as well as my friends and family. This was a really tough decision but with injuries taking me out of the Australian Open and Wimbledon, I need to fully heal prior to the US Open.”

Isner has played every possible ATP week since mid-June in Holland. The 14th-ranked Isner will be seeded No. 13 at the US Open which begins next Monday.

Berdych, who’s at a career-high No. 5 after his semifinal effort in Cincinnati, will be the fifth seed.

Isner beat Berdych last year in a third set tiebreak in the tournament final.

The news leaves No. 22 Tommy Robredo and No. 23 Andreas Seppi as the two highest ranked players at the Winston-Salem Open.

With Isner not playing, Rafael Nadal has won the US Open Series. So if the Spaniard wins the US Open he will earn an additional $1 million.

This means in New York, Rafa will be competing for the biggest payout in tennis history, a possible $3.6 million ($2.6 million for winning the U.S. Open and a $1 million bonus for winning the U.S. Open Series).