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It's the ultra-rare, sober Charlie Sheen. Many photographers have spent their entire lives trying to get this one shot. (Photo : Joella Marano)

CBS's Two and a Half Men premieres tonight, only without the famed half man, Angus T. Jones. Instead, a new leading lady will be joining the guys. House M.D star Amber Tamblyn will be playing Charlie Sheen's characters bi-sexual daughter.

Former House M.D. star Amber Tamblyn has been cast in the CBS hit comedy as the late Charlie Harper's unknown daughter Jenny.

Jenny's story has her coming to the house is search of Charlie. After she learns of her papa’s passing, she decides to stick around in order to get to know what remains of her new found family.

The apple apparently doesn't fall far from tree--like father like daughter--Jenny will also share her daddy's love for the ladies. Jenny will be a bisexual, allowing her to mimic her father's infamous ways, while still leaving room for sexual tension between her and co-star Ashton Kutcher.

Show creator Chuck Lorre spoke with the Television Critics Association over the summer about his choice to put a woman in what has been been undeniably a man’s world for the past ten years:

"I think it would be great to have a voice on the show from a different perspective, The show has had enough testosterone to last a lifetime. Part of the fun in this has been creating a character that is equal to the task of stepping on the stage with Jon Cryer and Ashton Kutcher. That's a big job. The idea of the character brings a healthy amount of decadence, which is always fun on Two and a Half Men."

Tamblyn will be filling a hole left behind by the departure of Angus T. Jones. The "half man," as the show's title suggests, is all but gone from the series and will only make rare guest spots from now on.

Jones, who came of age playing Jake on the comedy, had a crisis in faith that lead to a falling out with show producers last year. Jones, a Seventh-Day Adventist took issue with the shows adult themes, referring to himself as a "paid hypocrite" for his work on the controversial sitcom.

The new season starts tonight. Let us know what you think of the shows most recent cast change.