This talk will present the work of a multi-institutional, interdisciplinary collaborative of researchers and practitioners (School Reform and Beyond, SRB) who are developing research based interventions designed to improve academic outcomes for all children, particularly those from low-income households, from minority families, or with English language challenges. SRB's overarching goal is to build both knowledge and capacity and to develop a set of key research-practice partnerships that will enable us to create integrated and synergistic approaches to learning that target children's social, emotional and cognitive development. Ultimately we hope to develop and take to national scale a sustainable, efficient, and comprehensive set of interventions that accelerates learning from birth onward. The primary components of SRB's agenda include the following: (1) Maximizing the start to schooling (pre-K to Grade 3) by building upon the best evidence-based strategies for promoting academic proficiency, with strategies to promote self-regulated learning. (2) Elevating school readiness by supporting parents with research-based practices to more effectively prepare children from infancy (ages 0 to 3) for healthy, successful entry to pre-K. And, (3) optimizing non-educational contexts that research has demonstrated have the greatest synergistic impacts on age-appropriate learning and healthy development from birth onward. In particular, this talk will describe the key features of the SRB initiative, and will discuss the theoretical link between current advances in our understanding of children's social, emotional and cognitive development and key behavioral and academic outcomes for children. We will explain how this theory has been used to begin to develop, and implement, in partnership with a set of existing programs, an integrated suite of interventions designed to improve outcomes for children.