CA1 pyramidal neuron: Ih current (Migliore et al. 2012)

NEURON files from the paper:
Migliore M, Migliore R (2012) Know Your Current Ih: Interaction with a Shunting Current Explains the Puzzling Effects of Its Pharmacological or
Pathological Modulations. PLoS ONE 7(5): e36867.
doi:10.1371/journal.pone.0036867.
Experimental findings on the effects of Ih current modulation, which is particularly involved in epilepsy, appear to be inconsistent. In the paper, using a realistic model we show how and why a shunting current, such as that carried by TASK-like channels, dependent on the Ih peak conductance is able to explain virtually all experimental findings on Ih up- or down-regulation by modulators or pathological conditions.
Reference: 1 .
Migliore M, Migliore R (2012) Know your current I: interaction with a shunting current explains the puzzling effects of its pharmacological or pathological modulations
PLoS One7(5):e36867 [PubMed]