The ability of the drug to activate and induce a conformational change in the receptor after occupying the receptor

Intrinsic Activity

Both affinity and maximal intrinsic activity. The drugs that bind and interact with a receptor, thereby initiate a chemical reaction inside cell and produces effect

Agonist

Only the affinity but no intrinsic activity. A drug that binds to the receptor but can not activate it. It blocks the effect of an agonist for that receptor

Antagonist

Any drug that binds to a receptor and produces an opposite effect as that of an agonist. Will have affinity and negative intrinsic activity

Inverse Agonist

Will have affinity but submaximal intrinsic activity. When given alone the partial agonist activates receptor to produce an effect. However less response than a full agonist. When given along with an agonist, it will block the agonist action.

Partial Agonist

memorize

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Answer

The initial combination of drug with the receptor resulting in conformational changes in cell

Drug Action

The ultimate change in biological function as a consequence of drug action

Drug Effect

A series of intermediate steps between drug action and drug effect

Transducer Mechanism

ACh and GABA are examples of this receptor binding

Ligand-Gated Ion Channels Receptors

Epinephrine and Histamine are examples of this receptor binding

G-Protein Coupled Receptors

Insulin is an example of this receptor binding

Kinase-Linked Receptors

Steroids, Vitamin A, D, and Thyroxin are examples of this receptor binding

Intracellular Receptors

This is manifested as increased cardiac contractility, relaxation of smooth muscle, lipolysis, glyconeogenesis

ANS Introduction

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Answer

Largely concerned with consciously controlled functions such as movement, respiration, and posture

Somatic division

Largely autonomous (independent) in that its activities are not under direct conscious control. It is concerned primarily with visceral functions that are necessary for life - such as cardiac output, blood flow to various organs, digestion

Autonomic Nervous System (ANS)

Division of ANS into sympathetic and parasympathetic is determined by this