Dr. Chui's research focuses on brain-behavior correlations in dementia. Her research has examined clinical heterogeneity, natural history, clinical diagnosis, and clinical-pathologic correlations in Alzheimer Disease (AD) and vascular dementia. She is Director of the Alzheimer’s Research Center and has evaluated over 1400 patients at the Alzheimer Disease Diagnostic and Treatment Center since 1985. Clinical data from these patients have been entered into a clinical database and over 200 of these cases have come to autopsy for detailed neuropathologic assessment. The individual research project headed by Dr. Chui examines the pathophysiologic and functional significance of deep white matter changes and pathological correlates of ischemic lesions visualized by MRI. The overreaching goal of Dr. Chui’s work is to: 1) provide state-of-the-art clinical diagnosis and treatment for patients with dementia, 2) provide education to health professionals, caregivers, and the community, and 3) translate research findings into practice.