our results provide new insights into the mechanism of cellular intoxication by TcdA and the role of PACSIN2 in endocytosis.

proposed a packing model for the assembly of PACSIN 2 on membrane, where the proteins are connected by tip-to-tip and wedge loop-mediated lateral interactions on the surface of membrane to generate various diameter tubules

Study shows that PACSIN2 is involved in the regulation of gastrulation, possibly through regulating cell adhesion.

PACSIN2 Antigen Profile

Antigen Summary

This gene is a member of the protein kinase C and casein kinase substrate in neurons family. The encoded protein is involved in linking the actin cytoskeleton with vesicle formation by regulating tubulin polymerization. Alternative splicing results in multiple transcript variants.