@Article{Yazdekhasti2017,
author="Yazdekhasti, Hossein
and Rajabi, Zahra
and Akrami, Seyed Mohammad",
title="Ethical issues associated with advanced paternal age and genetic disorders in their offspring",
journal="Arvand Journal of Health and Medical Sciences",
year="2017",
volume="1",
number="4",
pages="-",
abstract="Nowadays, couples postpone parenthood into their fourth or fifth decade of life due to different reasons such as economic situation and industrialization. Several studies have shown disadvantages of advanced maternal age and its effects on offspring health. However, there are few studies concerning effects of advanced paternal age (APA) on offspring health. Hence, appropriate progress has not been made in genetic counseling of this issue. Some scientists believe that advanced age doesnâ€™t have detrimental effects on semen parameters, but majority of scientists are of the opinion that semen parameters such as volume, count, morphology and motility will decrease with increasing age. Moreover, it has been revealed that APA is in close relationship with incidence of some diseases such as Achondroplasia, congenital malformations, Autism, Schizophrenia and some cancers in infants. Based on the quadruplet ethical principles, the right of aged parents is conserved for childbearing, but genetic counseling along with conservation of parentsâ€™ autonomy would be useful to healthy childbearing.",
issn="2476-6275",
doi="10.22631/ajhms.2017.43224",
url="http://arvandj.abadanums.ac.ir/article_43224.html"
}
@Article{Ghasiyari2017,
author="Ghasiyari, Haniye
and Rostami Nejad, Mohammad
and Amani, Davar
and Chaleshi, Vahid
and Aghamohammadi, Elham
and Taleghani, Mohammad
and Kazemian, Shabnam
and Zali, Mohammad Reza",
title="Designing of specific primer pairs for quantitative analysis of TLRs (Toll-Like Receptors) genes in patients with celiac disease by polymerase chain reaction technique",
journal="Arvand Journal of Health and Medical Sciences",
year="2017",
volume="1",
number="4",
pages="-",
abstract="Celiac disease (CD) is an autoimmune enteropathy caused by an abnormal immune response to dietary gluten that occurs in genetically susceptible individuals. Recent studies suggest the crucial role of innate immunity in the pathogenesis of celiac disease. Toll-like receptors (TLRs) are pattern recognition receptors that play a central role in the initiation or maintenance of innate immune responses. Dysregulation of this innate immune receptors results in chronic inflammatory responses. The aim of this study was to investigate the new specific primer pairs for quantitative analysis of human TLR2, TLR4, TLR7 and TLR9 genes in blood samples of patients with celiac disease by polymerase chain reaction technique. At first the DNA of few confirmed patients with celiac disease was extracted directly from blood samples and PCR was carried out using specific primers for human TLR2, TLR4, TLR7 and TLR9 and then amplified PCR products was confirmed by gel electrophoresis.The result of this study showed that every four TLRs were detected correctly in blood samples of patients with celiac disease with specific size. Therefore we suggest that blood sample of celiac disease patients are alternative source for investigate the TLRs gene expression instead duodenal biopsy specimensÂ ",
issn="2476-6275",
doi="10.22631/ajhms.2017.43225",
url="http://arvandj.abadanums.ac.ir/article_43225.html"
}
@Article{Koushki2017,
author="Koushki, Mehdi
and Amiri Dash Atan, Nasrin
and Haghparast, Hesam",
title="Accuracy of Prediction circulating miR-126 in the Type 2 Diabetes: A Systematic review and Meta-Analysis",
journal="Arvand Journal of Health and Medical Sciences",
year="2017",
volume="1",
number="4",
pages="-",
abstract="Many studies have shown that microRNAs could play a role as predicting biomarkers. The aim of this study is investigation of predictive role of miR-126 in type 2 diabetic Mellitus (T2DM) patients. Eligible studies were selected from PubMed, MEDLINE, EMBASE, Science Direct, ProQuest databases and the information of these studies were extracted. The meta-analysis tests of standardized mean differences (SMD) with 95% confidence interval (95% CI), summary odds ratio, heterogeneity and publication bias performed using comprehensive meta-analysis version 3.0 (CMA) and STATA12 statistical analysis software. This meta-analysis included 6 studies association with circulating miR-126 in T2DM. Concentration of circulating miR-126 was lower with SMD (-0.131) (95% CI (-0.237) - (-0.025)) p-value (p= 0.016). The summary diagnostic odds ratio circulating miR-126 was (0.787) (95% CI (0.650) - (0.953)) and also sensitivities value was (42%) with a 5% false positive rate. I2= 0.00% and p= 0.5 indicating that non-significant heterogeneity between studies. Results of this study indicated that circulating miR-126 may be as a useful marker for accurate prediction of type 2 diabetes.Â ",
issn="2476-6275",
doi="10.22631/ajhms.2017.43226",
url="http://arvandj.abadanums.ac.ir/article_43226.html"
}
@Article{Izadi2017,
author="Izadi, Fereshteh",
title="miRNA-target network analysis in non-small cell lung cancer",
journal="Arvand Journal of Health and Medical Sciences",
year="2017",
volume="1",
number="4",
pages="-",
abstract="MicroRNAs (miRNAs) as small and endogenous noncoding RNAs regulate gene expression by repressing mRNA translation or decreasing stability of mRNAs and has proven key roles in different types of cancers. Accumulating evidences indicate the role of microRNAs (miRNAs) in a wide range of biological process from oncogenesis and tumor suppressors to participate in tumor development. Lung cancer specially non-small cell lung cancer is a frequently encountered challenging type of cancer, therefore exploring interactions among underlying biological units such as miRNA and their targets may be leads to identifying predominant clues involved in this malignancy. In this study differentially expressed miRNAs as an output of miARma-Seq tool from which 5 miRNA had experimentally validated targets in miRTarBase database were identified. Also transcription factors which enriched as regulators of them and biological process whereby these targets involved in were explored. Finally regulatory network of the rest of differentially expressed miRNAs was seek from MicroCosm and TargetScan. As a result we noticed that the most of target genes and transcription factors had direct relationship with lung cancer that might be imply on a strong conservation in a triangle of miRNA, target genes and a specific disease. These findings could be a potential bridge between miRNAs and non-small cell lung cancer invasive manner.",
issn="2476-6275",
doi="10.22631/ajhms.2017.43227",
url="http://arvandj.abadanums.ac.ir/article_43227.html"
}
@Article{Amiri2017,
author="Amiri, Fariba",
title="The effects of implementing family physician program on occupational health indicators in Hamadan province, Iran",
journal="Arvand Journal of Health and Medical Sciences",
year="2017",
volume="1",
number="4",
pages="-",
abstract="Health indicators are used for health management and planning. Since the family physician program was implemented in 2005 with the aim of improving health indicators and enhancing the referral system, it is necessary to assess the progress of this program by evaluating the related health indicators. The present study aimed to assess the effects of implementing family physician program on occupational health indicators in Hamadan Province, Iran.This cross-sectional study recruited all rural workshop workers covered by the family physician program. In order to examine the effects of implementing family physician program on occupational medicine and health indicators, the indicators were compared in two periods, 4 years before and 10 years after the implementation. Data were also collected by researchers through the provincial health department. Finally, data were analyzed and assessed by SPSS software using linear regression test and descriptive statistics.The implementation of family physician program had a significant effect on indicators of occupational health examinations in small workshops (P = 0.001) and rural workshops with less than 20 workers (P = 0.001), and musculoskeletal disorders indicators among workers in rural workshops (P = 0.002), and led to increasing growth of those indicators. The family physician program in rural areas improved occupational health indicators. Finally, it is concluded that this program can promote occupational health indicators, particularly occupational health examination indicators.Â ",
issn="2476-6275",
doi="10.22631/ajhms.2017.43228",
url="http://arvandj.abadanums.ac.ir/article_43228.html"
}
@Article{Okhovatian2017,
author="Okhovatian, Farshad",
title="Towards understanding topological features of protein interactome map of muscle cancer",
journal="Arvand Journal of Health and Medical Sciences",
year="2017",
volume="1",
number="4",
pages="-",
abstract="Muscle cancer despite being rare but it is important for more examination due to its high mortality risk. Here, applying protein-protein interaction PPI network, we analyzed proteins that are related to this neoplasm in more details. The String Database (db) as the source for network was used through Cytoscape 3.4. The centrality examination by Network Analyzer, Cytoscape plug-in is done. The findings indicate that there are some proteins with higher linkage to the disease and with central topological features. These hub-bottlenecks are TP53, AKT1, MYC, and KIT.Â The prioritized proteins in this analysis indicate that these molecules may have prominent role in interactome of muscle cancer; however, more investigation is required to establish this claim.",
issn="2476-6275",
doi="10.22631/ajhms.2017.43229",
url="http://arvandj.abadanums.ac.ir/article_43229.html"
}
@Article{Mirzaei-Alavijeh2017,
author="Mirzaei-Alavijeh, Mehdi
and Karami-Matin, Behzad
and van Lieshout, Sanne
and Mahboubi, Mohammad
and Zinat-Motlagh, Fazel
and Jalilian, Farzad",
title="Appling intervention mapping approach to promoting healthy diet intention among diabetic patients: an efficacy study",
journal="Arvand Journal of Health and Medical Sciences",
year="2017",
volume="1",
number="4",
pages="-",
abstract="Diabetes is the most common metabolic disorder and cause serious complications. A healthy diet is essential for diabetic patients in order to control and prevent disease complications. This study was conducted to evaluate the efficacy of a healthy diet promotion program among Type 2 diabetic patients in south of Iran, with applying the theory of planned behavior (TPB) as a theoretical framework. Overall, 150 patients with type 2 diabetic referred to rural health centers were participated in study and randomly allocated in two intervention (n=75) and control groups (n=75). The intervention group received the prepared program and control group received no intervention. The final evaluation took place in both groups, after 3 months of intervention. The data were analyzed using SPSS software, version 21. Findings indicated significant promotion in positive attitude toward healthy diet and general knowledge about nutrition among the intervention group. Considering the change methods and practical applications used in this study have been effective in changes attitude and knowledge determinants, therefore it is proposed to use them in large scale intervention study",
issn="2476-6275",
doi="10.22631/ajhms.2017.43230",
url="http://arvandj.abadanums.ac.ir/article_43230.html"
}
@Article{Eskandari2017,
author="Eskandari, Ali
and Gholami, Farangis",
title="The influence of industrial noise on urinary metanephrine, normetanephrine and vanilmandelic acid levels in workers of textile factory in Yazd, Iran",
journal="Arvand Journal of Health and Medical Sciences",
year="2017",
volume="1",
number="4",
pages="-",
abstract="Noise as the most common physical agent in workplace, not only causes hearing loss but also leads to various diseases, such as hypertension and cardiovascular disease. Sound is likely to stimulate and increase the secretion of adrenal catecholamines and may have an indirect role in the pathogenesis of diseases caused by stress. This study was performed to investigate the effect of noise on urinary levels of metabolites of catecholamines of workers in a textile factory in Yazd, Iran. The sound pressure level measured in different units of factory and the mill divided into two sections as noisy (leq â‰¥ 85db) and quite (leq â‰¤ 70db) units. Forty four eligible workers participated in this study (22 as study and 22 as control group) and their urine were collected before and after workday shift. Metanephrine and normetanephrine levels were measured using ELISA, and vanilmandelic acid level was measured using chromatography methods. Results were analyzed using Wilcoxon and Mann-Whitney statistical tests. Urinary level of metanephrine, normetanephrine and vanilmandelic acid in the study group was significantly higher than control group in both before and after shift samples. In study group level of all three metabolites were significantly increased after workday shift. In contrast, no significant increase was observed for metanephrine and vanilmandelic acid in control group but the increase of normetanephrines level was significant. Noise as a stressor factor may increase the exertion of catecholamines and this may can increases the risk of stress-related diseases.",
issn="2476-6275",
doi="10.22631/ajhms.2017.43231",
url="http://arvandj.abadanums.ac.ir/article_43231.html"
}