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Mapping production traits in farm animals: the Booroola (FecB) locus.

Abstract

The Booroola (FecB) locus has been mapped to sheep chromosome 6. M arkers flanking this gene were identified in sheep x ham ster somatic cell hybrids containing chromosomes 6 and 24. Partial genomic libraries were constructed from the cell lines, sheep-specific clones were selected from the libraries and microsatellite markers developed. Four markers mapped to sheep chromosome 6 and one marker mapped to sheep chromosome 24, demonstrating that chromosome-specific clones were generated from the hybrid cell lines and further defining the position of the FecB locus on sheep chromosome 6.