The Williams Sisters met at Wimbledon and meet again at the U.S. Open on Tuesday. Photo: reuters

Serena Williams is looking to complete the rare calendar Grand Slam and will need to go through her older sister to do it. On Tuesday, Serena faces Venus in the quarterfinals of the U.S. Open.

At age 33, Serena is attempting to become the first woman to complete the calendar Grand Slam since Steffi Graff in 1988. It would be yet another accomplishment for the world's No.1, who has won 21 Grand Slam titles and a gold medal in the 2012 Summer Olympics.

Serena owns a stunning 52-2 record in 2015, and has been particularly dominate in Grand Slams. She cruised to the Australian Open title, received some tough challenges but still prevailed at the French Open, and then rolled through Wimbledon competition. In the fourth round at Wimbledon, she defeated Venus, 6-4 6-3.

Serena has the edge on her older sister, owning a 15-11 head-to-head record, and has only lost one set at the U.S. Open this year. But Venus won their last match on hard court, defeating Serena in three sets in the semifinals of the Rogers Cup in Montreal in Aug. 2014.

An upset victory would be an enormous confidence booster for Venus, who has had her struggles in recent years. The 35-year-old is ranked No. 23 and continues to compete for an elusive eighth major tennis title, having failed to win a Grand Slam since Wimbledon in 2008. Venus hasn't taken home a title at Flushing Meadows since 2001, and this is her first time advancing past the third round at the U.S. Open since reaching the semifinals in 2010. She is quite aware of Serena's quest for glory in New York, but remains undeterred in her hopes of defeating her more accomplished sister.

"I don’t think anyone wants to be a spoiler," Venus said after her straight-sets win over Anett Kontaveit on Sunday. "I think people love to see history being made. No one is out to be a spoiler, but at the same time, you are focused on winning your match, even though the circumstances are really much different."

"She's beaten me so many times," Serena said. "I've taken a lot of losses off of her, more than anybody. Yeah, she's a player that knows how to win, knows how to beat me, and knows my weaknesses better than anyone. So it's not an easy match at all."