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Cell Sheet Migration Inhibitor, Locostatin is a cell-permeable N-(crotonyl)oxazolidinone compound that acts as a potent inhibitor of RKIP (Raf kinase inhibitor protein)/Raf-1 kinase interaction. Cell Sheet Migration Inhibitor, Locostatin has been shown to block eukaryotic cell migration (IC50 = 14 μM for inhibition of wound closure in MDCK cell monolayers) and decrease formation of lamellipodial protrusions at the wound margin. Cell Sheet Migration Inhibitor, Locostatin also inhibits early development in frog embryos and tissue dynamics in embryonic explants. Displays no antibacterial activity. May serve as a useful tool for studying RKIP-mediated signaling pathways. Although locostatin is an irreversible inhibitor of RKIP, its cellular effects are generally reversible due to new biosynthesis.

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