Posted - 2016.05.06 10:35:20 -
[182] - Quote
Hmmm, that is an obvious one! Do you have the image ID? I'd love to know what that protein's job is biologically.

I know the community seems to shy away from CCD, and that 's largely our fault since we don't train it very well as we haven't been annotating it in the past. Fear not though! I am currently working on an optimized cut-off for each class for the statistical significance required to consider a response. This should help with general community bias such as over-annotation of cytoplasm and under-annotation of CCD.

Posted - 2016.05.06 11:24:21 -
[183] - Quote
Yesterday I had my first clear centrosome image (mainly double-dots, but in some cells only one dot)! They seem to be quite rare. One question about them: I've read on Wikipedia that the centrosome "serves as the main microtubule organizing center (MTOC)". But in PD there is also the "microtubule organizing center" as a separate image classification (more a diffuse ball rather than one or two sharp dots). Hence I thought centrosome and MTOC would be two different biological objects. Are they actually the same organelle and only the green staining is sometimes sharp and sometimes diffuse for some reason?

Hmmm, that is an obvious one! Do you have the image ID? I'd love to know what that protein's job is biologically.

I know the community seems to shy away from CCD, and that 's largely our fault since we don't train it very well as we haven't been annotating it in the past. Fear not though! I am currently working on an optimized cut-off for each class for the statistical significance required to consider a response. This should help with general community bias such as over-annotation of cytoplasm and under-annotation of CCD.

Keep marking em! o7

I cant find how to get the image ID. I've found nothing on reddit, I'm not getting a response in game. I keep feeling like it is a simple answer.

in particular had me questioning myself. I've always had trouble with cytoskeleton intermediate filaments VS Endoplasmic reticulum, but never the cytoskeleton microtubules. What exactly makes this one microtubules over the filaments? (The cytokinetic bridge is pretty obvious here)

And while I'm on the subject, the classification I had a few slides before, had me questioning between cell junctions and focal adhesions. How can I more clearly make that distinction? If that classification is correct, then sometimes cell junctions can appear even when not next to another cell (Just black space on the slide)

in particular had me questioning myself. I've always had trouble with cytoskeleton intermediate filaments VS Endoplasmic reticulum, but never the cytoskeleton microtubules. What exactly makes this one microtubules over the filaments? (The cytokinetic bridge is pretty obvious here)

And while I'm on the subject, the classification I had a few slides before, had me questioning between cell junctions and focal adhesions. How can I more clearly make that distinction? If that classification is correct, then sometimes cell junctions can appear even when not next to another cell (Just black space on the slide)

Sorry for the late reply, didn't see this until now!

If you would toggle the green/red on/off you would see that there is a perfect overlap of individual strands which would lead one to the conclusion of microtubules.

Cell junctions should only appear where two cells are touching each other, not when there's black next to the cells. Focals would normally appear somewhat under the cell, not just at/outside the edge of it (and they can appear regardless whether the cell has neighbors or not).

If you would toggle the green/red on/off you would see that there is a perfect overlap of individual strands which would lead one to the conclusion of microtubules.

Cell junctions should only appear where two cells are touching each other, not when there's black next to the cells. Focals would normally appear somewhat under the cell, not just at/outside the edge of it (and they can appear regardless whether the cell has neighbors or not).

Posted - 2016.05.28 14:45:08 -
[194] - Quote
I'll bring this over from the other thread in the Information Center

Joia Crenca wrote:

I noticed that some of the Classification Samples are a bit questionable, still. I guess someone is noticing when one comes up with a large 'incorrect' percentage as pertains to players trying to identify it?

Also, when do I get my certificate of cell sample mastery from the University of Reykjavik?

I guess I need to go check Reddit myself. Is CCP finished with any further work on the mini-game? The reason I ask is I'm wondering if more helpful information could be a part of the module itself?

I noticed that some of the Classification Samples are a bit questionable, still. I guess someone is noticing when one comes up with a large 'incorrect' percentage as pertains to players trying to identify it?

Also, when do I get my certificate of cell sample mastery from the University of Reykjavik?

I guess I need to go check Reddit myself. Is CCP finished with any further work on the mini-game? The reason I ask is I'm wondering if more helpful information could be a part of the module itself?

Thanks folks!

We're really dependent on your input for finding questionable control images, so please report them at the reddit thread I mentioned a few posts ago.

Hehe, certficates do sound like a nice idea (although guess it might be us at KTH (Royal Institute of Technology) here in Stockholm that are responsible for the science part).

I don't know if they are finished, but feedback is always appreciated. There are some PD threads here at the EVE forum where people have been commenting on it earlier, but I think they've been quiet for a month or so now at least.

Posted - 2016.06.01 05:09:40 -
[196] - Quote
Hi, I just started today Project Discovery and so far made it to rank 4! My question is how long will this be available because this is something I been wanting to do since it was introduced earlier this year. And will there be more projects like this? Thank you

Hi, I just started today Project Discovery and so far made it to rank 4! My question is how long will this be available because this is something I been wanting to do since it was introduced earlier this year. And will there be more projects like this? Thank you

Yay, welcome to PD! (in case you haven't come across them there's a PD subreddit, an awesome ingame chat channel (search for Project Discovery) - great for asking questions about difficult images, and also a slack channel)

CCP has said that PD will be around as long as it's popular, so hopefully that means for a long time :)

Yesterday I had my first clear centrosome image (mainly double-dots, but in some cells only one dot)! They seem to be quite rare. One question about them: I've read on Wikipedia that the centrosome "serves as the main microtubule organizing center (MTOC)". But in PD there is also the "microtubule organizing center" as a separate image classification (more a diffuse ball rather than one or two sharp dots). Hence I thought centrosome and MTOC would be two different biological objects. Are they actually the same organelle and only the green staining is sometimes sharp and sometimes diffuse for some reason?

Hi Kolmogorow,

the centrosome is both. In the beginning it will be a ball but once the cell division starts it will separate and each part will migrate to the opposite poles of the cell. While doing this they are connected by the microtubuli.

Yesterday I had my first clear centrosome image (mainly double-dots, but in some cells only one dot)! They seem to be quite rare. One question about them: I've read on Wikipedia that the centrosome "serves as the main microtubule organizing center (MTOC)". But in PD there is also the "microtubule organizing center" as a separate image classification (more a diffuse ball rather than one or two sharp dots). Hence I thought centrosome and MTOC would be two different biological objects. Are they actually the same organelle and only the green staining is sometimes sharp and sometimes diffuse for some reason?

Hi Kolmogorow,

the centrosome is both. In the beginning it will be a ball but once the cell division starts it will separate and each part will migrate to the opposite poles of the cell. While doing this they are connected by the microtubuli.

That was a great reply!

I just want to add that MTOC differs from centrosomes (since we can't distinguish the individual centrosome/s), so it could be e.g. a protein in the pericentriolar matrix which is surrounding the centrosome, or vesicles that are clustering around the centrosomes.

Posted - 2016.07.16 05:18:49 -
[200] - Quote
I'm actually still doing this Project. I'll have to check whether the last update I've seen to the ranks coincides with reward updates. (I'm sitting on a lot of Analysis Kredits, lol)

What you see there is a cell undergoing cell division (mitosis). The chromosomes (DNA, blue) have duplicated and condensed and lined up next to each other. The microtubules (red) have disassembled to form the mitotic spindle (red), which will attach to sites on the chromosomes and will pull them apart with the help of centrosomes. This will result in two (small) daughter cells that each have a copy of the DNA. After division they don't immediately detach, but are sort of stuck together (via the cytokinetic bridge), before cut off at the cytokinetic bridge cleavage site.

In the first image it seems like there's some green staining overlapping with the red, which would suggest that the protein might help out with the pulling apart of the chromosomes. The second image seems to show an overlap with blue and green, possibly indicating a DNA-binding protein.

What you see there is a cell undergoing cell division (mitosis). The chromosomes (DNA, blue) have duplicated and condensed and lined up next to each other. The microtubules (red) have disassembled to form the mitotic spindle (red), which will attach to sites on the chromosomes and will pull them apart with the help of centrosomes. This will result in two (small) daughter cells that each have a copy of the DNA. After division they don't immediately detach, but are sort of stuck together (via the cytokinetic bridge), before cut off at the cytokinetic bridge cleavage site.

In the first image it seems like there's some green staining overlapping with the red, which would suggest that the protein might help out with the pulling apart of the chromosomes. The second image seems to show an overlap with blue and green, possibly indicating a DNA-binding protein.

Posted - 2016.11.26 04:58:38 -
[208] - Quote
I started playing this game but i was curious how um do you find a sistsrs of eve loyalty store? Do i have to go all the way to thera? I was thinking about grinding out one or two of those combat suits. One to keep and one to sell,

Posted - 2016.11.26 04:58:38 -
[209] - Quote
I started playing this game but i was curious how um do you find a sistsrs of eve loyalty store? Do i have to go all the way to thera? I was thinking about grinding out one or two of those combat suits. One to keep and one to sell,

Posted - 2016.11.29 19:05:00 -
[210] - Quote
Simplest way is to open the Agent Finder app in-game and search for a Sisters of EVE (corporation) agent. You can then see where their stations are.

I know a popular location is Arnon, where the Sisters of EVE Epic Arc starts, they have a station there. Gicodel, also, they have some agents there.

All you need is to find an SoE station, so you can click the LP Store button inside it. They have them in a bunch of places in high-sec, low-sec, and null.

EDIT: Also, the combat suits cannot be sold on the market, but they are available in the Contracts system for about 60 million ISK apiece, not bad. There's just a bug in their name that doesn't let you actually search the contracts interface for them; you have to set your Contract interface to show you Apparel, Outer Apparel, and then scroll down until you see the suits, male or female.

60 million ISK, as of yesterday. LP cost = 75,000 Project Discovery AK points + 37.5 million ISK. If you're starting Project Discovery from level 0, it'll take a while to get the AK points, as they are only rewarded as you level up, and only a few at a time.

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