Datasheet Extract

Application

flow cytometry / FACS analysis, immunoprecipitation

Background

T cell receptor (TCR) is a heterodimer consisting of an alpha and a beta chain (TCR alpha/ beta) or a gamma and a delta chain (TCR gamma/ delta). TCR gamma/ delta belongs to the immunoglobulin superfamily, involved in the recognition of certain bacterial and tumor antigens bound to MHC class I. The gamma/ delta TCR associates with CD3 and is expressed on a T cell subset found in the thymus, the intestinal epithelium, and the peripheral lymphoid tissues and peritoneum. Most gamma/ delta T cells are CD4-/CD8-, some are CD8+. T cells expressing the gamma/ delta TCR have been shown to play a role in oral tolerance, tumor-associated tolerance, and autoimmune disease. It has been reported that gamma/ delta T cells also play a principal role in antigen presentation. Immobilized UC7-13D5 antibody has been reported to activate gamma/ delta TCR-bearing T cells in vitro, and to deplete peripheral gamma/ delta TCR-bearing T cells in vivo.