SUZANNE L CASSELInflammation Program, Department of Internal Medicine, Graduate Program in Immunology, Department of Pediatrics, Department of Pathology, Department of Orthopedics, Dows Institute for Dental Research and Department of Periodontics, College of Dentistry, and Department of Epidemiology, University of Iowa, Iowa City, IA 52242Proc Natl Acad Sci U S A 111:1072-7. 2014

..These findings further illustrate that F. tularensis LVS possesses numerous genes that influence its ability to activate the inflammasome, which is a key host strategy to control infection with this pathogen in vivo...

..albicans. However, Nlrp10-deficient mice displayed a profound defect in Candida-specific Th1 and Th17 responses. These results demonstrate a novel role for Nlrp10 in the generation of adaptive immune responses to fungal infection...

SUZANNE L CASSELInflammation Program, Department of Internal Medicine, Graduate Program in Immunology, Department of Pediatrics, Department of Pathology, Department of Orthopedics, Dows Institute for Dental Research and Department of Periodontics, College of Dentistry, and Department of Epidemiology, University of Iowa, Iowa City, IA 52242Proc Natl Acad Sci U S A 111:1072-7. 2014

..These data provide a rationale for directly targeting IL-1RI or IL-1β as a therapeutic strategy in CRMO. ..

..One of the best-studied members of the NLR family is NLRP3 for which a number of divergent activators have recently been described. These and other studies examining the NLRP3 inflammasome will be discussed in this review...