The Yang Lab

The Zhu Lab

The Yang Lab

The Eric Olson Lab, in collaboration with the Howell Laboratory, has found that the secreted ligand Reelin promotes both orientation and dendritogenesis of neurons during early cortical development. This response occurs within 4 hr of Reelin application we are exploring the role of additional signaling systems that coordinate the positioning and integration of immature neurons within a forming cortical circuit. In this slide: Aberrant cellular orientation and dendritic growth in Reelin–sigaling deficient mutant compared to control littermate.