Poziotinib

Preclinical Studies Suggest Poziotinib Binds in the Active Site and Blocks ATP

Poziotinib is an investigational drug not yet approved by the FDA.

Poziotinib is a novel, orally available quinazoline-based tyrosine kinase inhibitor that irreversibly blocks signaling through the HER family of tyrosine-kinase receptors including HER1 (erbB1; EGFR), HER2 (erbB2), and HER4 (erbB4), as well as EGFR and HER2 mutations. This in turn can lead to blocking of downstream signaling and inhibition of the proliferation of tumor cells.

Apr 17, 2018
Data Showing Poziotinib Overcomes De Novo Resistance of HER2 Exon 20 Insertion Mutations in NSCLC and Other Cancers at the American Association for Cancer Research (AACR) in Chicago
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