Eligibility and Recruitment Information

Recruitment Status

Recruiting

Eligible Genders

Both

Eligible Ages

18 - 75

Inclusion

• Male or female subjects must be 18 to 75 years of age, at the time of signing the informed consent.
• Body mass index (BMI) of 18 to 35 kg/m2 for females and 18 to 40 kg/m2 for males, and total body weight >50 kg (110 lb).
• Clinically confirmed diagnosis AD.
• Eczema Area and Severity Index (EASI) score ≥16, body surface area (BSA) involvement ≥10%, and an Investigator's Global
Assessment (IGA) score (5-point scale) ≥3 at baseline.
• Subjects with a history of inadequate response to topical treatment, use of systemic treatments to treat AD, and/or for
whom topical treatments are otherwise medically inadvisable.
• Daily use of non-medicated emollient for at least 7 days prior to baseline.

Exclusion

• Treatment with topical corticosteroids, topical calcineurin inhibitors, or crisaborole within 2 weeks before dosing.
• Prior exposure to an anti-IL-33 antibody.
• Exposure to an investigational or licensed or other anti Th2 type cytokine or cytokine receptor antagonist within 16 weeks
or 5 half-lives, whichever is longer.
• History of prior exposure to any investigational or biologic systemic treatment within 5 half lives of the screening or is
currently enrolled in another clinical study.
• Have received systemic treatment for AD (including systemic corticosteroids, immunosuppressants or immunomodulating
drugs, or phototherapy or use of a tanning booth) within 4 weeks before screening.
• History of severe allergic or anaphylactic reactions to human, humanized, chimeric, or murine monoclonal antibodies.