The widow, Deputy Sheriff Jane Kozik, moves from Manhattan to Black Stone, New York, with her daughter Kelsey Kozik. There she expects to find a safe place to live. The day after moving, a homeless man is found dead in the tool shed of Jane's blind friend Beverly Rowe. Devin Hall and the entomologist Katherine Randell are summoned to help with the investigation. Devin is Jane's brother-in-law and former boyfriend, and Jane still has a crush on him. Meanwhile, Kelsey befriends the scientist Eli Giles, who has developed genetically modified wasps to the army as a weapon, and now he is trying to revert the process. When the wasps attack Black Stone, Jane, Devin and Eli team-up to attempt to destroy the swarm.

Unlike your typical mad scientist in a Sci-Fi Channel original movie who has tampered with insect kind in the name of battlefield readiness, Robert Englund’s Dr. Eli knows he did wrong when he messed with the wasp’s genome a decade earlier and has been on the lam from the military industrial complex with his swarm of weaponized wasps ever since desperately trying to “put the toothpaste back in the tube”. He does not, however, seem overly concerned that some of his wasps are out and about stinging certain members of the local populace, essentially turning those people into wasp incubators who shuffle about like barely lucid zombies acting under the control of the wasps’ collective hive mind, “drones” as he calls them. Then again, despite their odd behavior and multiple sting welts on their face and body, nobody else in town seems to notice them either; guess it really isn’t that big a deal after all.