Custom antibody development

We offer world-leading antibody development platforms based on a proprietary RabMAb® rabbit monoclonal platform, a phage display platform (AxioMx), and a next-generation sequencing platform (NGS-RabMAb®)

Preparation and Storage

This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

Alternative names

IL 23

IL 23 A

IL 23 subunit alpha

IL 23A

IL 23p19

IL-23 subunit alpha

IL-23-A

IL-23p19

IL12B

IL23

Il23a

IL23A_HUMAN

IL23P19

interleukin 12B

Interleukin 23 alpha subunit p19

Interleukin 23 p19 subunit

interleukin 23 subunit alpha

interleukin 23 subunit p19

interleukin six, G CSF related factor

Interleukin-23 subunit alpha

Interleukin-23 subunit p19

JKA3 induced upon T cell activation

MGC79388

P19

SGRF

see all

Function

Associates with IL12B to form the IL-23 interleukin, an heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to an heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.

Images

Functional Studies - IL23 P19 protein (ab109153)

IL17 secretion by Mouse splenocytes Mononuclear cells isolated from Mouse spleen were cultured with Mouse IL23 in presence or absence of various concentrations of ab109153 for 3 days. Levels of IL17 accumulated in culture supernatants were measured using ELISA.

References

ab109153
has not yet been referenced specifically in any publications.

Publishing research using ab109153? Please let us know so that we can cite the reference in this datasheet.