In mutation detection at single-cell resolution, besides using general QC metrics (like DP and GQ) to evaluate the quality of each variant call, you can remove low-quality variant calls caused by random error from DNA amplification and sequencing by using single-cell-related filters, such as (1) “variant found in multiple single cells” (at least 2–3, depending on the given cell number) and (2) “variant allele frequency is not rare” (>10%).