I know that PROLASTIN®-C LIQUID and the PROLASTIN DIRECT® program will be there for me, supporting me every step of the way

What is alpha1-antitrypsin deficiency?

Alpha1-antitrypsin deficiency (alpha-1) is a rare genetic disease often called "genetic COPD" because it can be passed down through families. If you have alpha-1, your body does not make enough alpha1 antitrypsin, a protein that protects your lungs.2

Approximately 100,000 people in the United States have alpha-1, but more than 9 out of 10 don't know they have it.3

What is PROLASTIN-C LIQUID?

PROLASTIN-C LIQUID is the trusted leader for more than 25 years. You're offered the convenience of receiving your infusion at home, work, an infusion center, and even when you are traveling.

PROLASTIN-C LIQUID is an alpha1-proteinase inhibitor (human) (alpha1-PI) indicated for chronic augmentation and maintenance therapy in adults with clinical evidence of emphysema due to severe hereditary deficiency of alpha1-PI(alpha1-antitrypsin deficiency). PROLASTIN-C LIQUID is a ready-to-use formulation that has been proven to effectively raise the alpha1-antitrypsin protein levels in patients with alpha-1.4

PROLASTIN-C LIQUID is contraindicated in IgA-deficient patients with antibodies against IgA due to the risk of severe hypersensitivity and in patients with a history of anaphylaxis or other severe systemic reactions to alpha1-PI.

Starting your PROLASTIN-C LIQUID therapy

Your doctor made the right choice when he or she put you on augmentation therapy to treat your alpha-1. PROLASTIN-C LIQUID is the #1 prescribed augmentation therapy, trusted by patients with alpha-1 and their doctors for more than 25 years.1

Transitioning from the lyophilized formulation to PROLASTIN-C LIQUID

PROLASTIN-C LIQUID is the same medicine you have been receiving in a lyophilized (powder) formulation, but is now available in a convenient liquid formulation, which means there is no need for mixing before your infusion.4

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PROLASTIN-C LIQUID: The trusted leader for more than 25 years

PROLASTIN-C LIQUID is the #1 prescribed augmentation therapy, trusted by patients with alpha-1 and their doctors for more than 25 years. More than 4 million PROLASTIN-C infusions have been performed around the world.1

IMPORTANT SAFETY INFORMATION

PROLASTIN®-C LIQUID is an alpha1-proteinase inhibitor (human) (alpha1-PI) indicated for chronic augmentation and maintenance therapy in adults with clinical evidence of emphysema due to severe hereditary deficiency of alpha1-PI(alpha1-antitrypsin deficiency).

Limitations of Use

The effect of augmentation therapy with any alpha1-PI, including PROLASTIN-C LIQUID, on pulmonary exacerbations and on the progression of emphysema in alpha1-PI deficiency has not been conclusively demonstrated in randomized, controlled clinical trials

Clinical data demonstrating the long-term effects of chronic augmentation or maintenance therapy with PROLASTIN-C LIQUID are not available

PROLASTIN-C LIQUID is not indicated as therapy for lung disease in patients in whom severe alpha1-PI deficiency has not been established

PROLASTIN-C LIQUID is contraindicated in immunoglobulin A (IgA)-deficient patients with antibodies against IgA or patients with a history of anaphylaxis or other severe systemic reaction to alpha1-PI products.

Because PROLASTIN-C LIQUID is made from human plasma, it may carry a risk of transmitting infectious agents, eg, viruses, the variant Creutzfeldt-Jakob disease (vCJD) agent, and, theoretically, the Creutzfeldt-Jakob disease (CJD) agent. This also applies to unknown or emerging viruses and other pathogens.

The most common adverse reactions during PROLASTIN-C LIQUID clinical trials in >5% of subjects were diarrhea and fatigue, each of which occurred in 2 subjects (6%).