Investigator, BC Children's HospitalAssociate Member, Department of Physiology, University of British ColumbiaHead, Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Faculty of Medicine, University of British Columbia

Academic Affiliations

Clinical Professor, Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Faculty of Medicine, University of British Columbia

Contact

There is increasing evidence to suggest that intestinal inflammation affects the organization and function of the intestinal nervous system, which controls how our intestine works. As a result, changes in nerve function may alter how the inestine works, worsen inflammation and aggravate the symptoms in IBD. In our studies we are examining the nerve-intestinal lining responses to inflammation in animal models if IBD and in our children with IBD. We will determine what nerve changes occur in assoications with intestinal inflammation, how these changes affectr the function of the intestinal lining cells and whether these changes persist. We will also examine the potential benfit of probiotics (living non-harmful bacteria).

We are also examining the effects of maternal dietary fat on intestinal lining cells (which protect the host from harmful dietary agents and infectious organisms) and on the intestinal immune response in young offspring.

Repression of Salmonella host cell invasion by aromatic small molecules from the human fecal metabolome.Applied and environmental microbiologyPeixoto RJM and Alves ES and Wang M and Ferreira RBR and Granato A and Han J and Gill H and Jacobson K and Lobo LA and Domingues RMCP and Borchers CH and Davies JE and Finlay BB and Antunes LCMDOI: 10.1128/aem.01148-17PubMed: 2875470707/2017

Capsule Endoscopy Complements Magnetic Resonance Enterography and Ileo-Colonoscopy in the Evaluation of Suspected Small Bowel Crohn’s Disease in Pediatric PatientsGastroenterologyDavid O. Prichard and Zachary Hamilton and Thomas Savage and Matthew Smyth and Carlie Penner and Alam Lakhani and Matthew Carroll and Ahmed A. Alsarkhy and Daniel Lemberg and Robert A. Enns and Robert J. Prosser and Daniel Jamieson and Kevan JacobsonDOI: 10.1016/s0016-5085(17)32196-004/2017

The Prevalence and Predictors of Anti-TNF Failure in a Population based Sample of Persons with IBDGastroenterologyLaura E. Targownik and Charles N. Bernstein and Harminder Singh and Aruni Tennakoon and Stella leung and Zoann Nugent and Lisa Lix and Kevan Jacobson and Juan-Nicolas Pena-Sanchez and Gilaad KaplanDOI: 10.1016/s0016-5085(17)31463-404/2017

Allied Health Professional Support in Pediatric Inflammatory Bowel Disease: A Survey from the Canadian Children Inflammatory Bowel Disease Network—A Joint Partnership of CIHR and the CH.I.L.D. FoundationCanadian Journal of Gastroenterology and HepatologyWael El-Matary and Eric I. Benchimol and David Mack and Hien Q. Huynh and Jeff Critch and Anthony Otley and Colette Deslandres and Kevan Jacobson and Jennifer deBruyn and Matthew W. Carroll and Eytan Wine and Johan Van Limbergen and Mary Sherlock and Kevin Bax and Sally Lawrence and Ernest Seidman and Robert Issenman and Thomas D. Walters and Peter Church and Anne M. GriffithsDOI: 10.1155/2017/36764742017

Association of host genome with intestinal microbial composition in a large healthy cohortNature GeneticsWilliams Turpin and GEM Project Research Consortium and Osvaldo Espin-Garcia and Wei Xu and Mark S Silverberg and David Kevans and Michelle I Smith and David S Guttman and Anne Griffiths and Remo Panaccione and Anthony Otley and Lizhen Xu and Konstantin Shestopaloff and Gabriel Moreno-Hagelsieb and Andrew D Paterson and Kenneth CroitoruDOI: 10.1038/ng.369310/2016

Pediatric Inflammatory Bowel Disease Among South Asians Living in British Columbia, CanadaInflammatory Bowel DiseasesMatthew W. Carroll and Zachary Hamilton and Hira Gill and Jonathan Simkin and Matthew Smyth and Victor Espinosa and Brian Bressler and Kevan JacobsonDOI: 10.1097/mib.000000000000065102/2016

Activity of SHIP, Which Prevents Expression of Interleukin 1ß, Is Reduced in Patients With Crohn's Disease.GastroenterologyNgoh EN and Weisser SB and Lo Y and Kozicky LK and Jen R and Brugger HK and Menzies SC and McLarren KW and Nackiewicz D and van Rooijen N and Jacobson K and Ehses JA and Turvey SE and Sly LMDOI: 10.1053/j.gastro.2015.09.049PubMed: 2648185402/2016

Tu1195 The Influence of Adolescent Transition Clinics on the Attitudes and Beliefs in Medicine in Patients With Inflammatory Bowel DiseaseGastroenterologyNancy Fu and Kevan Jacobson and Andrew M. Round and Kathi Evans and Hong Qian and Brian BresslerDOI: 10.1016/s0016-5085(14)62816-x05/2014

25-Hydroxyvitamin D concentrations in children with Crohn's disease supplemented with either 2000 or 400 IU daily for 6 months: a randomized controlled study.The Journal of pediatricsWingate KE and Jacobson K and Issenman R and Carroll M and Barker C and Israel D and Brill H and Weiler H and Barr SI and Li W and Lyon MR and Green TJDOI: 10.1016/j.jpeds.2013.11.071PubMed: 2442343104/2014

Attainment of Steroid-Free Clinical Remission and Normal Growth Among Canadian Children with Inflammatory Bowel DiseaseInflammatory Bowel DiseasesWalters Thomas and Benchimol Eric and Jacobson Kevan and El-Matary Wael and Deslandres Colette and Huynh Hien and Church Peter and Carroll Matthew and Wine Eytan and Mack David and Griffiths AnneDOI: 10.1097/01.mib.0000456870.74875.ed2014

The Relationship Between Common IBD-Associated Risk Alleles and Intestinal Permeability in a Cohort of Healthy First Degree Relatives of Individuals With Crohn's DiseaseGastroenterologyDavid Kevans and Karen Madsen and Mark S. Silverberg and Wei Xu and Konstantin Shestopaloff and Ummiye Venus Onay and Andrew D. Paterson and Anne M. Griffiths and Paul Moayyedi and Mark J. Ropeleski and Paul L. Beck and Charles N. Bernstein and Alain Bitton and Levinus A. Dieleman and David S. Guttman and Hien Q. Huynh and Kevan Jacobson and Gilaad G. Kaplan and John K. Marshall and Remo Panaccione and Ernest G. Seidman and Kathy Siminovitch and Denis Snider and Andrew Stadnyk and A. Hillary Steinhart and Michael Surette and Dan Turner and Bruce Vallance and Thomas D. Walters and Ken CroitoruDOI: 10.1016/s0016-5085(13)63107-805/2013

Inflammatory Bowel Disease in the Pediatric South Asian Population of British Columbia, Canada: A Distinct and Severe PhenotypeGastroenterologyMatthew W. Carroll and Hira S. Gill and Jonathan Simkin and Lee-Ann M. Carroll and Vered Pinsk and Victor M. Espinosa and Brian Bressler and Kevan JacobsonDOI: 10.1016/s0016-5085(13)62389-605/2013

Induction and Maintenance Therapy With Infliximab for Children With Moderate to Severe Ulcerative ColitisClinical Gastroenterology and HepatologyJeffrey Hyams and Lakshmi Damaraju and Marion Blank and Jewel Johanns and Cynthia Guzzo and Harland S. Winter and Subra Kugathasan and Stanley Cohen and James Markowitz and Johanna C. Escher and Gigi Veereman–Wauters and Wallace Crandall and Robert Baldassano and Anne GriffithsDOI: https://doi.org/10.1016/j.cgh.2011.11.0262012

Low Prevalence of Helicobacter Pylori Infection in Canadian Children: A Cross-Sectional AnalysisCanadian Journal of GastroenterologyIdit Segal and Anthony Otley and Robert Issenman and David Armstrong and Victor Espinosa and Ruth Cawdron and Muhammad G Morshed and Kevan JacobsonDOI: 10.1155/2008/4101762008

Induction and Maintenance Infliximab Therapy for the Treatment of Moderate-to-Severe Crohn’s Disease in ChildrenGastroenterologyJeffrey Hyams and Wallace Crandall and Subra Kugathasan and Anne Griffiths and Allan Olson and Jewel Johanns and Grace Liu and Suzanne Travers and Robert Heuschkel and James Markowitz and Stanley Cohen and Harland Winter and Gigi Veereman–Wauters and George Ferry and Robert BaldassanoDOI: 10.1053/j.gastro.2006.12.00303/2007

A Randomized Trial of Yoga for Adolescents with Irritable Bowel SyndromePain Research and ManagementLeora Kuttner and Christine T Chambers and Janine Hardial and David M Israel and Kevan Jacobson and Kathy EvansDOI: 10.1155/2006/7316282006

Positron Emission Tomography in the Investigation of Pediatric Inflammatory Bowel DiseaseInflammatory Bowel DiseasesDaniel A Lemberg and Robert M Issenman and Ruth Cawdron and Tim Green and John Mernagh and Stephen J Skehan and Claude Nahmias and Kevan JacobsonDOI: 10.1097/01.mib.0000172810.49619.cb08/2005

Canadian Helicobacter Study Group Consensus Conference: Update on the approach to Helicobacter pylori infection in children and adolescents--an evidence-based evaluation.Canadian journal of gastroenterology = Journal canadien de gastroenterologieBourke B and Ceponis P and Chiba N and Czinn S and Ferraro R and Fischbach L and Gold B and Hyunh H and Jacobson K and Jones NL and Koletzko S and Lebel S and Moayyedi P and Ridell R and Canadian Helicobacter Study GroupPubMed: 1601030007/2005

Canadian Helicobacter Study Group Consensus Conference: Update on the Approach to Helicobacter Pylori Infection in Children and Adolescents – an Evidence-Based EvaluationCanadian Journal of GastroenterologyNicola L Jones and Philip Sherman and Carlo A Fallone and Nigel Flook and Fiona Smaill and Sander Veldhuyzen van Zanten and Richard Hunt and Alan Thomson and Canadian Helicobacter Study GroupDOI: 10.1155/2005/3909322005

Canadian Helicobacter Study Group Consensus Conference: Update on the Management ofHelicobacter pylori- An Evidence-Based Evaluation of Six Topics Relevant to Clinical Outcomes in Patients Evaluated forH pyloriInfectionCanadian Journal of GastroenterologyRichard Hunt and Carlo Fallone and Sander Veldhuyzan van Zanten and Phil Sherman and Fiona Smaill and Nigel Flook and Alan Thomson and all participants of CHSG 2004DOI: 10.1155/2004/3267672004

A matched cohort study of feeding practice guidelines for infants weighing less than 1,500gAdvances in Neonatal CareSHAHIROSE S. PREMJI and LORRAINE CHESSELL and BOSCO PAES and JANET PINELLI and KEVAN JACOBSONDOI: 10.1053/adnc.2002.3151002/2002

Epstein-Barr Virus Infection in Transplant Recipients: Sumary of a Workshop on Surveillance, Prevention and TreatmentCanadian Journal of Infectious DiseasesUpton Allen and Caroline Alfieri and Jutta Preiksaitis and Atul Humar and Dorothy Moore and Bruce Tapiero and Raymond Tellier and Michael Green and Dele Davies and Diane Hébert and Sheila Weitzman and Martin Petric and Kevan Jacobson and Canadian PTLD Workshop Group #x2013; 1999DOI: 10.1155/2002/6343182002

Development of interstitial cells of Cajal in a full-term infant without an enteric nervous systemGastroenterologyJan D. Huizinga and Irene Berezin and Kanishka Sircar and Bryan Hewlett and Graeme Donnelly and Premysl Bercik and Catherine Ross and Talal Algofi and Peter Fitzgerald and Tara Der and Robert H. Riddell and Stephen M. Collins and Kevan JacobsonDOI: 10.1053/gast.2001.2120002/2001

Omeprazole for treatment of chronic erosive esophagitis in children: A multicenter study of efficacy, safety, tolerability and dose requirementsThe Journal of PediatricsEric Hassall and David Israel and Ross Shepherd and Michael Radke and Agneta Dalväg and Birgitta Sköld and Ola Junghard and Per LundborgDOI: 10.1067/mpd.2000.1096072000

CanadianHelicobacterStudy Group Consensus Conference on the Approach toHelicobacter PyloriInfection in Children and AdolescentsCanadian Journal of GastroenterologyP Sherman and E Hassall and RH Hunt and CA Fallone and S Veldhuyzen van Zanten and ABR Thomson and Canadian Helicobacter Study GroupDOI: 10.1155/1999/9342851999

Researchers at BC Children’s Hospital (BCCH) and the University of British Columbia have found a new sub-type of inflammatory bowel disease (IBD) that can be treated with existing drugs that target the body’s inflammatory response. This discovery may help children who have been diagnosed with Crohn’s disease but aren’t responding to current treatments.

Crohn’s disease and ulcerative colitis are gastrointestinal autoimmune diseases that can make it difficult for children to enjoy everyday activities and absorb the nutrients they need to grow. Shauna Crowley talks about how her research on the microscopic world inside our guts could lead to new treatments for these painful, lifelong conditions.

Kids with the highest blood-sugar levels experienced the most improvement after starting insulin pump treatment, according to new research. The study suggests insulin pump therapy should be considered for children with higher blood sugar levels to help avert some of the lifelong complications of diabetes.

Videos

Immunity 101 – an introduction to the immune system

Immunity – when you have too little

Immunity – when you have too much

Immunity – when it’s just right

Investigate the importance of the immune system. Uncover what happens when someone’s immune system is missing parts, explore why immunity sometimes goes awry, and understand how we can manipulate our knowledge of immunity to keep people healthier.

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