Licofelone, an experimental analgesic, causes less gastrointestinal (GI) adverse reactions than naproxen, according to a study involving healthy volunteers. Both are considered to be nonsteroidal anti-inflammatory drugs (NSAIDs), a group of drugs known for the potential to cause GI problems.

Researchers randomly assigned 121 volunteers to one of four groups. The volunteers took twice-daily doses of licofelone (200 mg or 400 mg), naproxen (500 mg), or a placebo. After 4 weeks, they underwent endoscopy. Twenty percent of those who took naproxen twice daily for 4 weeks developed stomach ulcers. No one in the groups taking licofelone or placebo developed an ulcer.

Licofelone is an inhibitor of both cyclooxygenase-1 (COX-1) and COX-2 and an enzyme called 5-lipoxygenase (5-LOX); consequently, it's categorized as a LOX-COX inhibitor. Naproxen is a non-selective COX inhibitor.

Other research has shown that licofelone, like conventional ...

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