Arbab, MBBS, PhD, receives 5-year subaward of NIH/NHLBI R01 Grant

Ali Syed Arbab, MBBS, PhD, received a 5-year, $26K subaward of an NIH/NHLBI R01 grant, “Chemokine signaling in EPC angiogenesis: A role of lysine methylation” awarded to Wayne State University.

Project Description: Endothelial progenitor cells (EPCs) are released from the bone marrow during cardiovascular diseases including vascular ischemic Injury, with their primary function being to repair injured blood vessels and restore normal cardiovascular function. The proposed study aims to explore a previously-unrecognized role and the underlying molecular mechanisms of lysine methylation of the chemokine receptor CXCR2 by a histone methyltransferase SMYD1 in modulating EPC migration and angiogenesis. The proposed research is relevant to public health because the mechanistic studies of CXCR2 methylation are likely to provide valuable information and potential therapeutic targets for enhancing EPC-based cell therapy for certain vascular diseases, as well as to fundamentally advance the field of chemokine receptor biology. Therefore, the work detailed in this proposal is relevant to NIH’s mission as it pertains to the pursuit of fundamental knowledge regarding the nature and behavior of living systems and the application of that knowledge to extend healthy life and reduce the burdens of illness.

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