Description:Some follicles contain germinal centers, areas in which B cells involved in an immune response are proliferating and undergoing somatic hypermutation see Section For example, reactive lymphocytosis due to a viral infection, such as in infectious mononucleosis, requires no specific treatment other than supportive care. Memory T cells also persist, like memory B cells, following immunization. B cells are produced as receptor-positive immature B cells in the bone marrow. The availability of such a wealth of new information presents several important challenges and opportunities.

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