The FBI has expanded its investigation into the disappearance of Yale graduate student Annie Le to a trash facility in Hartford.

The State Police Major Crimes Unit arrived at the trash facility around 2:15 p.m. Sunday afternoon.

The FBI's Bill Reiner said the search of the CRRA waste processing facility at 300 Maxim Road is an attempt to follow the trail of any trash that came out of the building at 10 Amistad St. in New Haven, where Le was last seen on Tuesday morning. ()

"We're searching for any investigative lead," he said.

State police and other investigators arrived at the CRRA site Saturday evening, said Paul Nonnemacher, spokesperson for the CRRA. Investigators wearing hazmat suits sifted through piles of trash with Bobcat machines and dogs through the night and remain there today. ()

Meanwhile, investigators searching for Le, 24, found bloody clothes above a ceiling tile in the building where Le was last seen, a police source told The Courant Saturday.

But no body had been found, and investigators were still searching for Le.

"The investigation is at a very difficult time," Lorimer said Saturday.

Kim Mertz, the FBI special agent in charge of the case, said Saturday that items that might be evidence have been collected from the research building at 10 Amistad St., in the Yale Medical School complex.

"We don't know if they could be associated with Annie Le," she said. "We have not identified anyone as a person of interest."

She added, "We're not in a position today to say whether this is a missing person case or whether criminality is involved."

University spokesman Tom Conroy said, "We don't know where she is, we don't know what happened to her."

Le, whose planned marriage today on Long Island has been canceled, has been the focus of an intensive search since her disappearance. Dozens of Yale, New Haven and state police and FBI agents have been involved in the search, which continues to focus on the Amistad Street building.

Police said they have interviewed numerous people, including some who saw Le inside the building.

Le was last seen entering the laboratory building about 10 a.m. Tuesday. But investigators have been unable to find any record of her leaving, despite spending hours poring over tapes from some 75 surveillance cameras that cover the complex.

Lorimer said it was "entirely perplexing that there doesn't seem to be a record of her" leaving the building, according to the Yale Daily News.

Investigators, having already gone through the videos once, were reviewing the surveillance tapes frame by frame to see if they overlooked Le, who could have changed into a laboratory coat or other clothing before leaving the building.

On Saturday, they brought in what appeared to be the building's blueprints. FBI agents also were spotted questioning an unidentified man outside the lab. When they finished talking, the man got into the front seat of an unmarked car and an FBI agent got into the back seat. The car then drove away.

Reiner said the FBI would not answer any questions about the investigation while it is still underway.

Yale is offering a $10,000 reward for information leading to Le's whereabouts. She is described as being of Asian descent, 4 feet 11 inches tall and 90 pounds. Her purse, cellphone, credit cards and money were found in her office in the lab building.

Le, originally from Placerville, Calif., was to get married today at the North Ritz Club in Syosset, N.Y. Workers at the club said the wedding was canceled on Friday.

Police said her fiancé, Jonathan Widawsky, a graduate student at Columbia University in New York City, is not a suspect and is assisting with the investigation.

During the evening, as many as six uniformed Yale and New Haven police officers stood guard outside the building's main entrance and the ramp to its parking garage. They carefully checked IDs of people who tried to get in, and turned away several. One woman arrived with a Yale ID card and told them she'd been called in to work that evening, but they sent her away, saying the basement -- where she was assigned to work -- was closed off.

Saturday evening, two young women strode to a tree along Amistad and put up a cardboard sign bearing the message "Annie -- We Hope You Are Okay!! -- Yale Grad Students."

One, who identified herself only as Kristina, said she and other Yale grad students are frightened and want more information from school administrators.

"The grad students are terrified," she said. "A lot of us are female and small, and we don't feel safe. We haven't heard anything from the dean of medicine or from anybody except the Yale police."

The woman said she doesn't know Le personally, but heard her give a presentation on pharmacology last year.