Concerta 72 mg may be warranted when symptoms of ADHD are not
responding to lower doses of the medication. Previous clinical
research demonstrates that a few weeks after taking their initial
dose of Concerta eight out of ten patients were given higher doses
of the medication to achieve effective symptom management. In a
clinical study of adolescents ages 13-18 years, Concerta 72 mg
significantly reduced ADHD symptoms, such as difficulty paying
attention to schoolwork.

Concerta tablets are currently available in 18 mg, 27 mg, 36 mg,
and 54 mg strengths. There is no 72 mg tablet. While physicians
will determine how the medication should best be taken by
adolescents for whom it is prescribed, it is believed Concerta 72
mg will most often be taken as a once-a-day morning dose of two
Concerta 36 mg tablets.

Concerta (methylphenidate HCl) CII is a once-daily
extended-release formulation of methylphenidate approved to treat
ADHD. The efficacy of Concerta has been demonstrated in studies
conducted in children and adolescents. Only a doctor can determine
if medication is the right treatment for individuals with ADHD.

Concerta uses an advanced OROS extended-release delivery system
to deliver a controlled rate of medication throughout the day,
minimizing the ups and downs in blood levels experienced with
stimulant medications taken several times a day.

Concerta should not be taken by patients with: significant
anxiety, tension, or agitation; allergies to methylphenidate or
other ingredients in Concerta; glaucoma, Tourette's syndrome, tics,
or family history of Tourette's syndrome; current/recent use of
monoamine oxidase inhibitors (MAOIs). Abuse of methylphenidate may
lead to dependence. Concerta should not be taken by children under
six years of age.

In clinical studies with children using Concerta, the most
common side effects were headache, stomach pain, sleeplessness, and
decreased appetite. In clinical studies with adolescents using
Concerta, the most common side effects were headache, accidental
injury, and, sleeplessness.

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