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This is a projectile that is fired from 40mm grenade launchers. They are much bigger than 25mm grenades, making them heavier and harder to fire at great speed. They deal 100 damage in a radius of 11.72 yards (10.72 meters).

The 40mm incendiary grenade deals 25% less blast damage up front (but the same amount of impact damage from the grenade itself) and has a 40% smaller blast radius (7.03 yards or 6.43 meters) than the normal 40mm, but it also causes enemies to burst into flames, dealing 6 damage every second over a 15 second period. This damage cannot normally be resisted, so incendiary grenades generally work better on armored targets.

A sub-type added with the new add-on Gun Runners' Arsenal. They deal an incredibly insignificant amount of damage (only 8 points) to targets and have a 50% smaller blast radius, but deal an extra 150 damage to robots and 60 damage to power armor.

Various roving non-player character bands (Legionaries, Vipers, Jackals) may spawn with grenade rifles or launchers, and associated ammunition. Unlike other weapons wielded by non-companion non-player characters, these use ammunition, so there may be none left unless they're killed before their supply is expended.