To evaluate its efficacy and tolerability, we performed a retrospective study of consecutive patients with Parkinson's disease (PD) who had received amantadine either as mono- or combination therapy for a 3-year period.

Evidence of widespread resistance of influenza to amantadine and rimantadine has prompted calls for restraint in antiviral use in order to preserve the therapeutic value of these adamantanes as well as newer generation agents.

If taken early, the antiviral agents amantadine and rimantadine are effective in reducing the severity of influenza A, while zanamivir and oseltamivir are effective in reducing the severity of both influenza A and B.

The M2 blocker amantadine is widely used and available without a prescription in some countries, including China, note Yi Guan and Honglin then, both of the University of Hong Kong and Shantou University Medical College in China.

Medications should be tapered in the order of those with the highest risk-to-benefit ratio: Anticholinergics should be tapered first, followed by selegiline, amantadine, dopamine agonists, and catechol 0-methyltransferase inhibitors.

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