The overall plot of Umbrella's End centres around the final assault on Umbrella at its Russian facility, which has been discovered thanks to reports of bizarre incidences at a nearby Russian village.

Chris Redfield and Jill Valentine set off with their own B.O.W.-countermeasure force to remove the threat, unaware that Albert Wesker has already arrived at the facility to recover Umbrella's research data, expecting to use Chris and Jill as the clean-up crew.