Working with Phillip, Holly, Eamonn and Ruth has been nothing but a pleasure, so knowing I will officially be part of the family from October is really exciting. I can't wait to get cracking.

”

On 2012, Willis began hosting the ITV2 reality show Girlfriends, which returned for a second series in 2013.[9]

On 16 November 2012, Willis was drafted in to guest anchor Loose Women and has since presented on several occasions as a stand-in presenter. She covered for Carol Vorderman after she broke her nose in April 2013.[10] She has also guest presented an episode of The Paul O'Grady Show, while O'Grady was away.[11]

In 2007, Willis guest hosted the tenth week of Big Brother's Big Mouth. In 2010, Willis began presenting a Celebrity Big Brother online spin-off show entitled Celebrity Big Brother's Big i. While presenting the online spinoff in the same series, Willis also presented another edition of Big Mouth when Davina McCall entered the Big Brother house as part of a task. She was then later announced as the new co-presenter on the final series of Big Brother's Little Brother, hosting opposite George Lamb.

On 13 March 2013, it was reported that Brian Dowling would be axed from Big Brother[15] and be replaced by Willis with a source saying, "Brian has been a great host but Emma is seen by channel chiefs as a true successor to Davina. They're talking to her now about taking over the role from the summer."[5] It was later confirmed, on 2 April 2013 by Channel 5 that Willis would be replacing Dowling as the new host of Big Brother.[4][16] On 13 June 2013, she began presenting the fourteenth series of Big Brother.

Even though Willis presents the main Big Brother and celebrity series, she still continues to host the spin-off show Bit on the Side, sharing the presenting duties with Rylan Clark. On 2 February 2015, it was announced that Willis was to present her final edition of Bit on the Side that night, and Clark would take over as the main presenter of the spin off show.[17]

On 30 March 2014, Willis presented the Mum of the Year Awards, with the highlights being shown on Channel 5 that same evening.[18]

In September 2013, Willis received a longlist nomination for 'Most Popular Entertainment Presenter' at the National Television Awards in 2014. It was her second successive longlist nomination for the award.[24]