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it can be many things the starter, alternator, the grounding wire or bad battery it wouldn't be specifically they ignition switch. It happened to me on a mazda and it was the starter that had gone bad.

You have a main wiring harness that plugs in to the column. Verify this is tight. That harness powers everything, including your ignition. If you removed your ignition and reinserted it into the new column, then verify it is in the correct position and also locked in the correct position. The E-150 could also have the shifter on the column? It is possibly not lined up right and isn't in park. Check shift position and verify it is in park or neutral.

remove the stering columns plastic covers & it will expose the ignition lock
unplug the wiring loom & unbolt it [2 bolts]
they ma be original bolts that the head breaks off so you cant unbolt the [antitheft system]
if they are then you will neeed a steel punch & hammer to start them turning out!
Cheers Rob

If you mean actually replacing the ignition switch on the vehicle with a locking column. You need to do this. Dicconnect the battery, remove the lower panel of the dash if there is any. There is a bolt on the steering column near the fire wall on most vehicles, remove this bolt, it will release the spline on the steering column. Disconnect all wiring going to the column, unbolt the column from the dash support. Remove the column from the truck, on the ignition switch you will see where the two shear bolts screw the assembly together, center punch the center of each bolt. Now drill the bolt with a 1/8" drill about 1/4" to 3/8" deep. Now use a 3/8" drill and drill out the shear head until it comes off the bolt. You can now remove the switch assembly from the column. The new assembly should come with new shear off bolts so when you bolt it in place when tightned they will break off rendering it tamperproof again. Most vehicles are designed like this now to stop theft. Check the column for operation before reinstalling it in the reverse of above. You just want to make sure the key locks and unlocks the column before reinstalling in the vehicle. You may want to do this before you totally tighten the bolts and break them off permanently. Good luck, RAC

The wire that supplies a live to your radio, runs from ignition down the steering column. You probably have a chafed wire along that loom, as you tilt the steering, the wire grounds so the accessories fuse/radio fuse blows. Remove the panel under the steering column and/or the shroud around the column and examine the wiring.