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Description

A complete reference for fermentation engineers engaged in commercial chemical and pharmaceutical production, Fermentation and Biochemical Engineering Handbook emphasizes the operation, development and design of manufacturing processes that use fermentation, separation and purification techniques. Contributing authors from companies such as Merck, Eli Lilly, Amgen and Bristol-Myers Squibb highlight the practical aspects of the processes—data collection, scale-up parameters, equipment selection, troubleshooting, and more. They also provide relevant perspectives for the different industry sectors utilizing fermentation techniques, including chemical, pharmaceutical, food, and biofuels.

New material in the third edition covers topics relevant to modern recombinant cell fermentation, mammalian cell culture, and biorefinery, ensuring that the book will remain applicable around the globe. It uniquely demonstrates the relationships between the synthetic processes for small molecules such as active ingredients, drugs and chemicals, and the biotechnology of protein, vaccine, hormone, and antibiotic production. This major revision also includes new material on membrane pervaporation technologies for biofuels and nanofiltration, and recent developments in instrumentation such as optical-based dissolved oxygen probes, capacitance-based culture viability probes, and in situ real-time fermentation monitoring with wireless technology. It addresses topical environmental considerations, including the use of new (bio)technologies to treat and utilize waste streams and produce renewable energy from wastewaters. Options for bioremediation are also explained.

Key Features

Fully updated to cover the latest advances in recombinant cell fermentation, mammalian cell culture and biorefinery, along with developments in instrumentation

Readership

Engineers and scientists in the chemical and pharmaceutical industries who use fermentation techniques in production. Development, design, engineering and production personnel in the fermentation industry

Table of Contents

Dedication

Preface to the Third Edition

Preface to the Second Edition

Preface to the First Edition

In Memory of Henry C. Vogel

List of Contributors

Part I: Fermentation

Chapter 1. Fermentation Pilot Plant

Prologue

1.0 Microbial Fermentation

Further Reading

Chapter 2. Mammalian Cell Culture System

1.0 Introduction

2.0 Culture Media

3.0 Microcarrier Culture and General Control Parameters

4.0 Perfusion Culture Systems as a New High Density Culture Technology

5.0 Sedimentation Column Perfusion Systems

6.0 High Density Culture Using a Perfusion Culture System with Sedimentation Column

Acknowledgment

References and Bibliography (Section 2)

Further Reading

Chapter 3. Bioreactors for Plant Cell Tissue and Organ Cultures

1.0 Background of the Technique—Historical Overview

2.0 Media Formulations

3.0 General Applications

4.0 Bioreactors—Hardware Configuration

5.0 Bioreactor Size

6.0 Culture Period

7.0 Aeration and Agitation

8.0 Microbial Contamination

9.0 Characteristics

10.0 Manipulation

11.0 Scale-up Problems

12.0 Bioprocess Measurement and Control

References (Section 3)

Further Reading

Chapter 4. Nutritional Requirements in Fermentation Processes

1.0 Introduction

2.0 Nutritional Requirements of the Cell

3.0 The Carbon Source

4.0 The Nitrogen and Sulfur Source

5.0 The Source of Trace and Essential Elements

6.0 The Vitamin Source and Other Growth Factors

7.0 Physical and Ionic Requirements

8.0 Media Development

9.0 Effect of Nutrient Concentration on Growth Rate

References

Further Reading

Chapter 5. Fermentation for Biofuels and Bio-Based Chemicals

1.0 Introduction, History, and Theory

2.0 Fermentation Organism Development for a Biofuel- or Bio-Based Chemical Product

3.0 Biofuel- or Bio-Based Chemical Fermentation Process Development and Design

4.0 Practical Applications

5.0 Plant Operations

6.0 References

7.0 Examples of Biofuel- and Bio-Based Chemical Industrial Production Processes