Griseofulviin (microsize)

GRISEOFULVIN (MICROSIZE)

ATC

Added

1 year ago on 19 December 2016

Drug information on epgonline.org reflects the approved license for the product. We do not hold any information on availability, reimbursement or local recommendations. We do not sell or supply any drug products; please contact your local pharmacy/formulary.

Indication(s)

INDICATIONS AND USAGE Major indications for Griseofulvin Oral Suspension are: Griseofulvininhibits the growth of thosegenera of fungi that commonly cause ringworm infections of the hair, skin, and nails, such as: Note:

Prior to therapy, thetypeoffungiresponsible for the infection should be identified.

The use of the drug is not justified in minor or trivialinfections which will respond to topical antifungal agents alone.

The study evaluated the efficacy and safety of letermovir (MK-8228) for the prevention of clinically-significant CMV infection in adult, CMV-seropositive recipients of allogeneic hematopoietic stem cell transplant (HSCT).

This study will evaluate the efficacy, safety, and tolerability of treatment with sofosbuvir/velpatasvir/voxilaprevir (SOF/VEL/VOX) fixed-dose combination (FDC) for 12 weeks and of sofosbuvir/velpatasvir (SOF/VEL) FDC for 12 weeks...

This study will evaluate the efficacy, safety, and tolerability of treatment with sofosbuvir/velpatasvir/voxilaprevir (SOF/VEL/VOX) fixed-dose combination (FDC) for 8 weeks and of treatment with sofosbuvir/velpatasvir (SOF/VEL) FDC for 12 weeks...

This study will evaluate the safety and efficacy of treatment with sofosbuvir/velpatasvir/voxilaprevir (SOF/VEL/VOX) and SOF/VEL in adults with chronic HCV infection who have not previously received treatment with direct-acting antiviral therapy.

Advisory information

CONTRAINDICATIONS This drug is contraindicated in patients with porphyria, hepatocellular failure, and in individuals with a history of hypersensitivity to griseofulvin. Two cases of conjoined twins have been reported in patients taking griseofulvin during the first trimester of pregnancy. Griseofulvin should not be prescribed to pregnant patients.

PRECAUTIONS Patients on prolongedtherapywithanypotentmedicationshouldbe under closeobservation.

Periodic monitoring of organ system function, including renal, hepatic and hemopoietic, should be done.

Since griseofulvin is derived from species of penicillin, the possibility of cross sensitivity with penicillin exists; however, known penicillin-sensitive patients have been treated without difficulty.

Since a photosensitivity reaction is occasionally associated with griseofulvin therapy, patientsshouldbewarned to avoidexposuretointense natural or artificialsunlight.

Should a photosensitivity reaction occur, lupuserythematosusmaybeaggravated.

DrugInteractionsPatientsonwarfarin-typeanticoagulanttherapymayrequiredosageadjustmentoftheanticoagulant during and after griseofulvin therapy.

Concomitant use of barbiturates usually depresses griseofulvin activity and may necessitate raising the dosage.

The concomitant administration of griseofulvin has been reported to reduce the efficacy of oral contraceptives and to increase the incidence of breakthroughbleeding.

ADVERSEREACTIONS When adversereactions occur, they are most commonly of the hypersensitivity type such as skin rashes, urticaria and rarely, angioneurotic edema or erythema multiforme-like drug reaction, and may necessitate withdrawal of therapy and appropriatecountermeasures.

Paresthesias of the hands and feet have been reported rarely after extended therapy.