Marvel confirmed the news from Latino Review that Saffron Burrow will be playing the role of Victoria Hand in the November 12th episode of 'Marvel's Agents of S.H.I.E.L.D.'

According to the Marvel Wikia:

Three years before the Skrull Invasion, Victoria Hand was an accountant for S.H.I.E.L.D., who was in a relationship with another agent named Isabelle. Victoria was determined to send a letter informing Director Nick Fury how he was mishandling the War on Terror. Isabelle implored Victoria not to send the letter but Victoria did anyways and was transferred immediately to Portland, Oregon. As a result, Isabelle, furious that she did not listen to her, ended their relationship.

Marvel released some new images from the episode to confirm her appearance.