Hearts Get 'Younger,' Even At Middle Age, With Exercise

Eventually it happens to everyone. As we age, even if we're healthy, the heart becomes less flexible, more stiff and just isn't as efficient in processing oxygen as it used to be. In most people the first signs show up in the 50s or early 60s. And among people who don't exercise, the underlying changes can start even sooner.

"The heart gets smaller — stiffer," says Dr. Ben Levine, a sports cardiologist at University of Texas Southwestern Medical Center and director of the Institute for Exercise and Environmental Medicine at Texas Health Presbyterian Hospital, in Dallas.

Think of the heart muscle as a rubber band, Levine says. In the beginning, the rubber band is flexible and pliable. But put it in a drawer for 20 years and it will emerge dry and brittle.

"That's what happens to the heart and blood vessels," he says. And down the road, that sort of stiffness can get worse, he notes, leading to the breathlessness and other symptoms of heart failure, an inability of the heart to effectively pump blood to the lungs or throughout the body.

Fortunately for those in midlife, Levine is finding that even if you haven't been an avid exerciser, getting in shape now may head off that decline and help restore your aging heart. He and his colleagues published their recent findings in the American Heart Association's journal, Circulation.

The research team recruited individuals between the ages of 45 and 64 who were mostly sedentary but otherwise healthy.

Dallas resident Mae Onsry, an accounts payable manager, was 62 at the time. Raising two children and working full time, she says, she never had the flexibility to fit in exercise, although she knew it was important for her health.

"I have my hobbies," says Onsry, including ballroom dancing and gardening. But it was nothing routine, nothing "disciplined," she says.

So when she saw a flyer about Levine's study, she signed up — along with 52 other volunteers — for a two-year study.

Participants were randomly assigned to one of two groups. The first group engaged in a program of nonaerobic exercise — basic yoga, balance training and weight training — three times a week. The other group, which Onsry was in, was assigned a trainer and did moderate- to high-intensity aerobic exercise for four or more days a week.

After two years, the group doing the higher-intensity exercise saw dramatic improvements in heart health.

"We took these 50-year-old hearts and turned the clock back to 30- or 35-year-old hearts," says Levine. Their hearts processed oxygen more efficiently and were notably less stiff.

"And the reason they got so much stronger and fitter," he says, "was because their hearts could now fill a lot better and pump a lot more blood during exercise."

The hearts of those engaged in less intense routines didn't change, he says.

A key part of the effective exercise regimen was interval training, Levine says — short bursts of high-intensity exercise followed by a few minutes of rest. The study incorporated what are often referred to as 4x4 intervals.

"It's an old Norwegian ski team workout," Levine explains. "It means four minutes at 95 percent of your maximal ability, followed by three minutes of active recovery, repeated four times."

Pushing as hard as you can for four minutes stresses the heart, he explains, and forces it to function more efficiently. Repeating the intervals helps strengthen both the heart and the circulatory system.

"The sweet spot in life to get off the couch and start exercising [if you haven't already] is in late middle age when the heart still has plasticity," Levine says. You may not be able to reverse the aging of the vessels if you wait.

"We put healthy 70-year-olds through a yearlong exercise training program, and nothing happened to them at all," Levine says. "We could not change the structure of their heart and blood vessels."

Anyone considering beginning this, or a similarly strenuous exercise program, Levine says, should check with a doctor first and ask about individual health issues that might warrant a less intense program initially.

For Onsry, who is now 65, the study was life changing. Today she exercises every day of the week, walking and jogging at least 5 miles around the lake near her home.

If she misses a day, she says, she just doesn't feel as good physically. And the regimen has helped her mental health, too.

"I'm not moody," she says. "I mean — I'm happy."

Dr. Nieca Goldberg, a cardiologist and medical director of the Joan H. Tisch Center for Women's Health at NYU Langone Medical Center, and a spokeswoman for the American Heart Association, says Levine's research is important.

"Many studies that are done that look at [cardiovascular] health look at improvements in risk factors like high blood pressure, cholesterol and diabetes," Goldberg says. "But this study specifically looked at heart function — and how heart function can improve with exercise."

Goldberg says the findings are a great start. But the study was small and needs to be repeated with far larger groups of people to determine exactly which aspects of an exercise routine make the biggest difference.

Copyright 2018 NPR. To see more, visit http://www.npr.org/.

RACHEL MARTIN, HOST:

All right. If you haven't been an avid exerciser, never fear. It's not too late, necessarily. A recent study shows that if you take up routine exercises even in late middle age, you can actually reverse some of the damage that a sedentary lifestyle does to your heart. Here's NPR's Patti Neighmond.

NEIGHMOND: And eventually it doesn't pump blood as efficiently as it used to, making some activities difficult.

LEVINE: The pressure inside the heart goes up really high, and the blood will back up into the lungs, making people very, very short of breath.

NEIGHMOND: Levine studies exercise and fitness at the University of Texas Southwestern Medical Center. He wanted to know if starting routine exercise in midlife or even later could prevent this decline in the heart. He recruited patients between 45 and 64 who were otherwise healthy but did not exercise. Mae Onsry (ph) was 62 at the time.

MAE ONSRY: I have my hobbies - I do ballroom dancing - in my leisure time that I like. And I do gardening.

NEIGHMOND: Enjoyable, but not a daily routine.

ONSRY: No discipline.

NEIGHMOND: Onsry was one of 53 volunteers in Levine's study who were divided into two groups. One did weightlifting and yoga three days a week. Onsry was in the other group which did moderate to high-intensity exercise most days of the week. After two years, the group doing the more frequent, higher intensity exercise saw dramatic improvements in heart health.

LEVINE: We took these 50-year-old hearts and turned the clock back to 30- or 35-year-old hearts.

NEIGHMOND: Their hearts processed oxygen more efficiently and were notably less stiff.

LEVINE: And the reason that they got so much stronger and fitter was because their hearts now could fill much better and pump a lot more blood during exercise.

NEIGHMOND: The hearts of those doing less regular exercise didn't change. For Mae Onsry, the study was life changing. Today she exercises every day of the week, walking and jogging at least five miles. If she misses a day, she says she just doesn't feel good. And it's helped her mental health, too.

ONSRY: I'm not moody. I mean, I'm happy.

NEIGHMOND: A key part of the exercise regimen was interval training, short bursts of high-intensity exercise followed by a few minutes of rest. For example, Levine says, this four-by-four interval training.

LEVINE: It's an old Norwegian ski team workout. It means four minutes at 95 percent of your maximal ability followed by three minutes of active recovery, repeated four times.

NEIGHMOND: Pushing as hard as you can for four minutes stresses the heart and forces it to function more efficiently. Levine says if you haven't done high-intensity exercise and decide to start, make sure you build up gradually. Cardiologist Nieca Goldberg, spokesperson for the American Heart Association, says Levine's findings are important.

NIECA GOLDBERG: Many studies that are done that look at cardiovascular health look at improvements in risk factors for heart attack and stroke, such as high blood pressure, high cholesterol and diabetes. But this study specifically looked at heart function and how heart function can improve with exercise.

NEIGHMOND: Goldberg says the findings are a great start. But the study was small, and it needs to be repeated with far larger groups of people. Patti Neighmond, NPR News. Transcript provided by NPR, Copyright NPR.