Aging, Dementia and Traumatic Brain Injury Project

The Aging, Dementia and Traumatic Brain Injury Project is a detailed neuropathological, molecular and transcriptomic characterization of brains of control and TBI exposure cases from a unique, population-based aged cohort from the Adult Changes in Thought (ACT) study of aging and dementia.

KEY FEATURES:

t-Distributed Stochastic Neighbor Embedding (t-SNE) plots paired with Parallel Coordinates plots designed to reduce the complexity of this high-dimensional dataset, allowing relationships in the data to be explored

Donor weights for making inferences that apply to the entire ACT Cohort

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Additional Data in the ACT Study and How to Access It

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The ACT study is a longitudinal population-based prospective cohort study of brain aging and incident dementia in the Seattle metropolitan area. ACT is a Repository administered by the Group Health Research Institute (GHRI), which has established policies and procedures for sharing data with external investigators. Data available from this project web site do not require any additional Institutional Review Board (IRB) approval or permissions. Linking those data with other ACT study or Group Health data would require additional review which can be initiated by contacting ACTproposals@ghc.org.