This article reviews the development of novel treatments for fibromyalgia, discussing pharmacologic and nonpharmacologic interventions and whether any of these are truly effective at treating the condition.

Is there evidence for any truly effective therapy in fibromyalgia?

During the past 20 years alone, nearly 3000 peer-reviewed manuscripts have been published on various aspects of the treatment of fibromyalgia (FM). This has included hundreds of randomized clinical trials (RCTs) evaluating pharmacologic and nonpharmacologic management as well as systematic reviews.

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