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(Phys.org) —A team of researchers from the University of California has found that one part of the brain in rats responds differently to virtual reality than to the real world. In their paper published in the journal Science, ...

When a mammal explores an unfamiliar environment, ensembles of place cells in the hippocampus fire individually, recording specific locations in a cognitive map that aid future spatial navigation of the area. ...

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(PhysOrg.com) -- The hippocampus, a brain area associated with memory and stress, was about six percent smaller on average in veterans with current chronic PTSD than in veterans who had recovered from PTSD, in a study conducted ...

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(PhysOrg.com) -- Scientists have long puzzled over the many hours we spend in light, dreamless slumber. But a new study from the University of California, Berkeley, suggests we're busy recharging our brain's learning capacity ...

All our daily activities, from driving to work to solving a crossword puzzle, depend on signals carried along the body's vast network of neurons. Propagation of these signals is, in turn, dependent on myriad small molecules ...

Hippocampus

The hippocampus is a major component of the brains of humans and other mammals. It belongs to the limbic system and plays important roles in long-term memory and spatial navigation. Like the cerebral cortex, with which it is closely associated, it is a paired structure, with mirror-image halves in the left and right sides of the brain. In humans and other primates, the hippocampus is located inside the medial temporal lobe, beneath the cortical surface. Its curved shape reminded early anatomists of the horns of a ram (Cornu Ammonis), or a seahorse. The name, in fact, was taken by the sixteenth century anatomist Julius Caesar Aranzi from the Greek word for seahorse (Greek: ιππος, hippos = horse, καμπος, kampos = sea monster).

In Alzheimer's disease the hippocampus is one of the first regions of the brain to suffer damage; memory problems and disorientation appear among the first symptoms. Damage to the hippocampus can also result from oxygen starvation (hypoxia), encephalitis, or medial temporal lobe epilepsy. People with extensive hippocampal damage may experience amnesia—the inability to form or retain new memories.

In rodents, the hippocampus has been studied extensively as part of the brain system responsible for spatial memory and navigation. Many neurons in the rat and mouse hippocampus respond as place cells: that is, they fire bursts of action potentials when the animal passes through a specific part of its environment. Hippocampal place cells interact extensively with head direction cells, whose activity acts as an inertial compass, and with grid cells in the neighboring entorhinal cortex.

Because of its densely packed layers of neurons, the hippocampus has frequently been used as a model system for studying neurophysiology. The form of neural plasticity known as long-term potentiation (LTP) was first discovered to occur in the hippocampus and has often been studied in this structure. LTP is widely believed to be one of the main neural mechanisms by which memory is stored in the brain.