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Creative Data Solutions (CDS) is a Vanderbilt Shared Resource and has extensive experience in providing effective and robust solutions to challenges pertaining to research data using modern informatics and bioinformatics approaches.

Bader Lab

The work in the Bader laboratory has focused on the
commitment, differentiation and function of cardiac and vascular
cells in the embryo. The early heart development and vasculogenesis
provide excellent systems to examine fundamental issues in
developmental biology. Current projects are focused on the function
of two genes that were discovered in the Bader lab and the
analysis of a conserved system whereby coelomates generate vessels
to organs during development.

LEK1 is a large and complex protein that regulates proliferation
and differentiation of cardiac myocytes. The Bader lab has
determined that LEK1 proteins function in cell movement,
trafficking and division through its interaction with Rb proteins,
the cytoskeleton, and the SNARE complex. Ongoing work is focused on
conditionally inhibiting the function of this gene in developing
mice and continuing studies of LEK1 interaction with subcellular
domains.

Bves, discovered by a former member of the lab, is a protein
that is essential for proper cell/cell interaction during coronary
vessel development. Bves is one of the first proteins
trafficked to points of cell/cell contact and it associates with
cytoplasmic proteins that regulate cell/cell adhesion, process
formation and movement. The lab is working to determine how the
disruption of Bves function impacts embryonic development in
vertebrate and invertebrates.