Altered metabolism has long been recognized as a defining characteristic of tumor cells. The increased glycolytic phenotype, an observation credited to Otto Warburg in 1956, is almost universal for cancer cells, making metabolic enzymes attractive...

Before and after views of Variety Records and other stores in a shopping center. In the before, the building is covered with faded and chipped white brick. In the after, Perma Stone siding has been installed in a thing pattern.

Oral history interview conducted on May 9, 1979 with Frances Smith by Mary Bobo. Mrs. Smith, a former nursing home owner and administrator discusses her childhood in Russellville, Kentucky, moving to Louisville at age twelve to tend to an aunt,...

Oral history interview conducted with Ruth Bryant on July 24, 1977 by Kenneth L. Chumbley. Mrs. Bryant, a community activist, primarily discusses her involvement in community organizing and political activism during the 1960’s in Louisville. ...

No current microfabrication technique exists for producing room-temperature, high-precision, point-to-point polymer nanofibers in three dimensions. Producing rounded structures in a third dimension is particularly difficult to accomplish with...

For complex detection and classification problems, involving data with large intra-class variations and noisy inputs, no single source of information can provide a satisfactory solution. As a result, combination of multiple classifiers is playing...

This exploratory study proposes a model for examining the evolutionary nature of immigration policy, the Cappiccie Lawson Evolution Immigration Model (CLEIM). The model was applied to the United States, Germany, and Russia to provide a broad...

Children with disabilities--Education (Secondary); Vocabulary--Study and teaching (Secondary); Mathematics--Study and teaching (Secondary)

Constant Time Delay (CST) has been used extensively as a procedure to teach children with disabilities a variety of skills. There is a preponderance of evidence that this instructional strategy is a highly effective (Handen & Zane, 1987;...

Great Lakes Exposition in Cleveland, Ohio, seen from the air at night. There are a variety of buildings and other structures, including a performance "shell," and the lake can be seen in the background. There are beams of colored light...

The reaction between an aminooxy moiety (RONH2) and a carbonyl group of either an aldehyde or a ketone — known as an oximation reaction — is a versatile click chemistry coupling that generates a robust oxime ether linkage. The oximation...

Early detection of human organ diseases is of great importance for the accurate diagnosis and institution of appropriate therapies. This can potentially prevent progression to end-stage disease by detecting precursors that evaluate organ...

This thesis proposes a network based intrusion detection approach using anomaly detection and achieving low configuration and maintenance costs. A honeypots is an emerging security tool that has several beneficial characteristics, one of which is...

A Book of Hours was the primary text for private lay devotion in the late middle ages and Renaissance. Consisting of the cycle of prayers to be recited at the eight canonical hours or established times for prayers throughout the day, the content of...

Since 2001, the Federal government has invested approximately $10 billion to expand broadband infrastructure throughout the nation, including various loan programs and grants authorized through Farm Bills and, more recently, the American Recovery...

Background The anthracycline doxorubicin (DOX) is widely used as an effective antineoplastic drug. Cardiotoxicity leading to congestive heart failure is the primary factor limiting the clinical use of DOX. However, although a variety of approaches...

This dissertation describes research focused on the synthesis, polymerization and
applications of cationic aminooxy lipids. An efficient and convenient method was
developed to stabilize liposomes using 'click chemistry'. The 'click...

The chemical analysis of atmospheric dust is of interest to two major groups, namely—the workers in industrial hygiene and the workers in the air cleaning and ventilating industries. The industrial hygienists, who are concerned with the...