The overall objective of the final phase of the INDEPTH (International Deep Profiling of Tibet and Himalaya) project has been to develop a better understanding of the structure and evolution of the northern margins of the ...

Glycosylation is an enzymatic process through which glycans attach to proteins, lipids and other organic molecules with huge structural diversity. This is a common post-translational modification found on proteins and cell ...

In this age of pervasive internet access we have become accustomed to rely
on web search for our most basic information needs. But complex queries in
knowledge-intensive organisations, as well as in the academic environment, ...

Toll like receptors (TLRs) are key players in host defence, homeostasis and response to injury. However, uncontrolled and aberrant TLR activation has been proposed to trigger the onset of certain neurodegenerative disorders ...

TRAIL is a member of the TNF family of cytokines which can selectively induce apoptosis in cancerous cells. For this reason recombinant TRAIL is being considered for the treatment of cancer. During their development cancer ...

The advent of on-demand computing facilitated by computational clouds, provides an almost unlimited resource supply to support the execution of applications and processes. Through a process known as virtualisation large ...

Although corneal transplantation success rates are high within the first year, the prognosis is much less favourable 5 years post-transplantation with immune-mediated rejection the primary cause of allograft failure. For ...

The biomechanisms which govern the response of chondrocytes to mechanical stimuli are poorly understood. This thesis aims to provide a more in depth understanding of chondrocyte biomechanics by focusing on the role of actin ...

Social communities shape the way people interact. E.g. members of online discussion communities frequently exchange information, experience, or knowledge about practically anything from software to bird watching. The rising ...

The hydroxyl radical, OH, is the key oxidant in the atmosphere as it reacts with
most trace gas species, often being the first and rate limiting step. The
oxidation leads to products that are more easily removed from ...

Despite many technological advances, the information overload problem still prevails in many application areas. It is challenging for users who are inundated with data to explore different facets of a complex information ...