Synopsis: Most of the media is treating the idea that the COVID-19 pandemic might have been the result of a lab escape as a wild and reckless accusation. Yet there is a long and extensive history of Potential Pandemic Pathogens (PPPs) escaping from labs all over the world. H1NI flu, for example, is now considered to have been a lab escape as was the UK’s Foot and Mouth disease (FMD) virus outbreak of 2007. Most of these escape events and their consequences are virtually unknown outside of their specialist fields, however. This article provides an overview.