Spectrum® Hollow Fiber Filtration and Dialysis Solutions

Spectrum®, a Repligen brand, offers a broad range of hollow fiber filtration technologies for upstream cell culture and downstream purification applications, as well as membrane dialysis solutions. Click below for a complete list of all Spectrum products and services.

KONDUiT is an add-on module ready to use with Spectrum® KR2i and KMPi TFF Systems and Pro-Connex™ Flow Paths, with the ability to scale from 1mL to 1000L process volumes. Using single-use, gamma stable sensors, the KONDUiT can be used with hollow fiber or flat sheet TFF filters and can automate process control parameters defined by weight, conductivity, and UV independently or in conjunction with each other.

To the existing integrated functions of the KR2i and KMPi systems, KONDUiT adds:

End point conductivity control for ultrafiltration / diafiltration operations

End point UV control for diafiltering free drug from drug delivery particles

Spectrum® hollow fiber filters are used in microfiltration and ultrafiltration applications. They are especially effective for tangential flow filtration (TFF) because they are easily scaled up or scaled down, maintaining the same filtration conditions from process development to commercial production.

Linearly scalable from process development to commercial manufacturing

Fast, high flux rates enable rapid processing

High yield, due to low protein binding

Manufactured in compliance with cGMP guidelines

Used in over 1900 Spectrum® Krosflo TFF Systems and over 2000 XCell™ ATF Systems worldwide

Spectrum® KrosFlo® Tangential Flow Filtration (TFF) systems are turnkey hollow fiber systems used in ultrafiltration and microfiltration processes. With filter volumes ranging from a few milliliters to thousands of liters, the KrosFlo System sizes parallel the scalability of Spectrum® hollow fiber filters.

Membrane dialysis is a gentle filtration process in which small solutes diffuse from a high concentration solution to a low concentration solution across a semipermeable membrane until equilibrium is reached. Repligen dialysis solutions include: