Dothiepin Vs Fluoxetine Mechanism Of Action And Pharmacodynamics

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Dothiepin Vs Fluoxetine Mechanism of Action and Pharmacodynamics

Comparison Between Mechanism of Action and Pharmacodynamics of Dothiepin and Fluoxetine

Description of medicines

Mechanism of action and pharmacodynamics

Dothiepin

Dothiepin is a tricyclic antidepressant. It acts by promoting the effectiveness of several amines (dopamine, norepinephrine, and 5-hydroxytryptamine, which is also known as 5HT and serotonin). It functions by inhibiting their reuptake at the terminals of nerve cells, thus leading to their prolonged presence at the synaptic cleft and an increased effect on the neuron.(1) The reuptake pumps for the above amines are responsible for reducing the concentration of these amines. Dothiepin works by blocking the pumps.

According to the amine hypothesis, a decreased concentration of the amines and the resulting decrease in amine dependant synaptic transmission is associated with depression, therefore an increase in the above would help relieve the sy...

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