ABOUT

Create high value brand of products for health and beauty, under standardized medicinal research and development facilities

Aesthetic Zecret (At-Ze) Company Limited is a producer of cosmetic, cosmeceutical, and dietary supplement (OEM); we provide to customers who want to own a business in health and beauty. At-ZE provides its services with its highly experienced staffs, which are extremely expert in product development. The company was found on the idea of producing high quality cosmeceutical and dietary supplement that answer our customer’s demands. We emphasizes on quality of products that we’re distributing, such as, quality of the raw materials. We only select high quality raw material from world’s leading manufacturers, such as, from Europe and America. We revalidate each and every production process, from production to finished products. We’re thorough with every step, in order to ensure the quality and standard of our products, from receiving customer’s order to production and innovation of new formula that best matches our customer’s demands. We’re confident with our innovation, research and creation of new formula, as we have experts on cosmeceutical and a team of expert doctors who serve as our advisor.

We applies the same standard as pharmaceutical factory in our cream production, which makes us superior, whether in term of our personnel, quality control, production process, facilities and equipments. You may rest assure that every product of our company has been thoroughly researched and developed by experts, and is conformed to all standards that global enterprises are emphasized, for the sake of quality’s excellence, and maximum efficiency of organization’s operation, such as, ISO 9001:2008, GMP, HACCP HALAL and etc; for the goal of becoming producer and exporter of high quality products, with highly reliable standards for production, whether in term of professionalism, innovation, and service. As we promise,

you can always rest assure that...

creation of brand of health and beauty “AT-ZE, ALL-IN-ONE”

Research and Development

We have teams of scientists, pharmacists, chemists, and doctors, who have experience and expertise in product research and development. Therefore, we’re always confident in our quality and safety. The origin of our research is the idea of producing non-stop product development. Such continuity in our research and development yields as our expertise in data analysis’s accuracy. Meanwhile, we have researchers who are expert in research and development of each product line; that we’ve divided into various teams, in accordance with their target product. Therefore, our customers may rest assure that the results of our innovation and products that we’re distributing to the consumers are all of high value and quality, with international standardized safety.

Quality Control

Aesthetic Zecret has solid quality control over our product. Before we deliver any products to our customers, quality of these products has to be thoroughly tested and validated. Our quality control covers the entire production process, from checking quality of received raw materials for production, to verifying that production process is conforming to GMP Standard, as well as ensuring that packaging is done with given standard, and then deliver the finished products to our customers, completely and wholly. We do all of these to ensure the maximum satisfaction of our customers.

Production

In our cosmetic production process, we’re thoroughly and meticulously planning, controlling and checking each and every step and process. Our production is done and controlled by our staffs, who are expert in cosmetic production, and by state of the art equipment; in order to produce only products of high quality and standard that may maximize our customer’s satisfaction.

Systematic and production standard

Clean room: we perform our production in the clean room, and conform to production standards, like GMP/PICs. GMP / PICs has very strict requirement to ensure that Manufacture using

GMP / PICs will have very good quality and high safety for consumers. GMP/PICs is good manufacturing practice, a standard for medicine production of European countries. GMP/PICs impose very strict regulation, in order to make sure that products that had been produced under GMP/PICs will represent highest quality and safety to customers.

- Clean room’s wall will be seamless and smooth. It doesn’t allow accumulation of dust but facilitates cleaning. The wall is made of PU (Polyurethane) material, which represents very low thermal conductivity. Therefore, it allows better control of temperature of the production’s area. Moreover, the area where wall meets with floor is covered with PVC, in order to prevent dust accumulation. - Clean room’s wall is made of 2-layers, flat type, safety glass which guarantees absolutely no dust accumulation. Nitrogen gas is pumped in between, in order to prevent foggy when ambient temperature has changed. In the area where extreme cleanliness is required, air lock will be provided. The air lock system is equipped with door control system that prevents concurrent opening of doors on both sides, in order to prevent contamination from rushing air into the clean room. Also, Magnehelic differential pressure gage is installed in front of each clean room, in order to control the room’s air pressure under given standard.

GMP/PICs requires usage of HVAC System for ventilation, as follow

Cold and dried air isn’t suitable for microorganisms. Therefore, atmosphere of our production area is maintained; where ambient temperature is set at 22±2 degree Celsius, relative humidity is between 50±10%RH at all time, during production.

- In order to control the cleanliness of, and dust in, the air of the production room, air pressures of each room set at different level, so the air ventilation is forced to flow at the right direction. Air of the production room is forced to flow through HEPA filter (high efficiency particulate air filter), and therefore, air is always clean in production room. - Air change ratio is high, of more than 25 air changes. Such high air change rate allows faster ventilation, hence, more air will be flowed through the filter and as a result, more clean air is ventilated in the system. Comparing to general factory that doesn’t use HVAC system, roughly 2-5 air changes. - The production area has strict control over particle in the air, at Grade D, which is the same as Cleanliness Class 100,000. This means in the 1 cubic foot of air, there will be less than 100,000 particles with the size of 0.5 micron or bigger.- Air in the production area is collected regularly, in order to analyze for quantity of microorganisms in the air, which has to be at less than 100 cfu (colony forming unit) by Settle plate (diameter 90 mm) for 4 hours. - Swirl diffuser-type air grille is used in the production area, which forces the air flow into one direction. Therefore, air in the production area will not mix with fresh air that has been pump into the system; and hence, air in the production area is highly pure and faces no risk of contamination

GMP/PICs requires usage of HVAC System for ventilation, as follow

- Cold and dried air isn’t suitable for microorganisms. Therefore, atmosphere of our production area is maintained; where ambient temperature is set at 22±2 degree Celsius, relative humidity is between 50±10%RH at all time, during production.- In order to control the cleanliness of, and dust in, the air of the production room, air pressures of each room set at different level, so the air ventilation is forced to flow at the right direction. Air of the production room is forced to flow through HEPA filter (high efficiency particulate air filter), and therefore, air is always clean in production room. - Air change ratio is high, of more than 25 air changes. Such high air change rate allows faster ventilation, hence, more air will be flowed through the filter and as a result, more clean air is ventilated in the system. Comparing to general factory that doesn’t use HVAC system, roughly 2-5 air changes. - The production area has strict control over particle in the air, at Grade D, which is the same as Cleanliness Class 100,000. This means in the 1 cubic foot of air, there will be less than 100,000 particles with the size of 0.5 micron or bigger.- Air in the production area is collected regularly, in order to analyze for quantity of microorganisms in the air, which has to be at less than 100 cfu (colony forming unit) by Settle plate (diameter 90 mm) for 4 hours. - Swirl diffuser-type air grille is used in the production area, which forces the air flow into one direction. Therefore, air in the production area will not mix with fresh air that has been pump into the system; and hence, air in the production area is highly pure and faces no risk of contamination

Purified water production system, in accordance with GMP/PICs Standard

Purified water production, in accordance with GMP/PICs Standard, requires high performance water production system which ensures that quality of water is conformed to the standard (high quality) at all time during the system’s operation (high consistency). Purified water, in accordance with definition of USP (United State Pharmacopoies) may come from various processes, such as, distillation, ion exchange treatment, reverse osmosis and etc. Purified water must be completely pure with zero contamination of other substances.

1. In order to produce purified water, in accordance with GMP/PICs standard, the purifier system has to be designed and controlled strictly. For starter, any materials that come into contact with water, such as, pipe and valve, must be made of stainless grade 316L, a grade of stainless steel that has lower carbon content and hence lower chance of corrosion and rust in the pipe. Surface roughness (Ra) of the pipe’s surface must be 0.8 micron at least. 2. As surface of stainless 316L pipe is required to come into contact with water at all time, the surface was hence subjected to Passivation; a process which boosts stainless steel against corrosion. 3. Connecting the pipe is done with orbital welding; which is a state of the art welding technique that has been validated. Therefore, one may rest assure that the welding is seamless and presents zero potential point for forming of rust or biofilm. 4. In water purifier system under GMP/PICs Standard, Diaphrame valve will be used; components of this valve place zero obstruction to water flow and therefore presents very low chance for forming of dirtiness or biofilm, compare to other types of valve, such as, butterfly valve or ball valve. 5. Water purifier system controls and maintains water flow at between 1-3 meters/second, in order to prevent accumulation of microorganisms at any point in the pipe, which is major cause of biofilm. 6. Microorganisms in the water are controlled by using UV-C (254 nm). Moreover, water purifier system controls the flow and UV ray’s concentration proportionately, in order to make sure long enough contact time that result as effective decontamination. 7. Designing of the water purifier system has made sure that, in the system’s pipe and valve, there will be no part that contributes as Zero Dead Leg, an area where there is no water circulation. Therefore, chance of biofilm accumulation is really thin within the system. 8. Purified water storage is closing storage container, where external air is prevented from ever coming into direct contact with the internal air by air vent, that has HEPA filter system; therefore, the system has absolute contamination proof against ventilation. 9. Although water purifier system was designed and implemented in a manner that present virtually no chance of contamination, however, after long period of operation, there will need for cleaning of sanitization system. And for this need, the company chooses to use Heat System, where heat will rapidly and efficiently kill all germs. Therefore, you don’t need to worry about any leftover residue.

Factory’s production process

Our company is running large cream mixing machine, which is capable of producing large batch of cream, between 30 to 500 kilograms at a time. The production process is performed by highly experienced staffs that have extensive work experience in cream and cosmetics production.

Our overall production capacity are100 tons per year for cream/lotion80 tons per year for gel

Quality Control

Every step of our production is controlled by high efficient analysis tools, both chemical and microbiological analysis. Testing our product in each and every step of production is extremely important, as there is no other way to know whether any of the major ingredients and substances in our products had been deteriorated. We test our products by using HPLC (high performance liquid chromatography) and spectrophotometer techniques; in order to make sure that the final products will contain all the required important substances, at the right amount.

Drug, cosmetic and dietary supplement research and development.

In order to create confidence among our customer, we only select raw materials and natural extracts that come from reliable sources. We created and tested various products, we tested products’ stability and potential irritation, we sought and provide technical information and document that customers want. Development of each product should mainly initiate from customer’s demands and those who have the best knowledge of our skin’s needs are dermatologists. Dermatologist has thorough knowledge about skin, from merely skin’s cells to its DNA; and he know physical characteristic of each cosmetics, for examples, if any cosmetic’s viscosity is too high and hence unsuitable for dried or oily skin; or whether any particular cosmetic is usable by those who has highly sensitive skin reaction; or what kind of cream should a person with irregular skin condition should use; and what are the best active ingredients and base creams for each type of skin. Next, there are pharmacists. Pharmacist is responsible for making decision about specific chemical components of each product, for examples, what components or ingredients should be added into one particular cream. The formula will be brought to scientist, who will now improve the cream’s content, fragrance, color, viscosity, physical characteristic; so it is now best suit customer’s demands. Lastly, scientist will test and verify the cream’s chemical components.

Clinical trial, as perform by dermatologist.

We employ volunteer, who will help us perform the clinical trial, along with using statistics in measurement of result

In our clinical trial, we test the product’s result with many analysis equipments, such as, pigment measuring machine, skin moisture measuring, skin elasticity measuring, wrinkle depth measuring, dermato invisible visualizer; and test for invisible changes of skin from our clinical trial with Spincontrol – major cosmetic testing institution from France. We perform such complex testing and gain all the required certifications, in order to reassure our customers on our product’s quality. Our customer may also use these cosmetics’ certifications for marketing purpose.

Testing for product’s active ingredients.

This is also another important test, as there is no way for us to know that, between each production steps, had any of the product’s active ingredients been deteriorated. We test our products by using HPLC (high performance liquid chromatography) and spectrophotometer techniques; in order to make sure that the final products will contain all the required important substances, at the right amount.

The last test if testing for cream’s stability. In this step, we test the cream’s short term and long term stability; to see whether there is any change in the cream’s content; does it change in color or fragrance; and most importantly, does our products contain all the active ingredients at the right amount, as our customer demands? We give utmost attention to each step of our product’s research and development, in order to ensure our customers that ‘our products are all of high quality and reliable.’

Aesthetic Zecret Co., Ltd.

We truly hope that we will be a part of your production line and that you will be confident in our products. We’re ready to walk along the path toward your success as leading business in beauty. We’re ready to be the driving force of your production and to develop products of high efficiency that always match the market’s demands. We’re ready to provide all these services and products with highly efficient personnel and team of highly experienced researchers, as well as state-of-the-art, standardized machinery. We’re always ready to bring only the best to and for you, ‘believe in us.’

The reason why it has to be us, AT-ZE

We have standardized factory, under GMP and ISO 22716.

We’re confident with our production process; which gives tangible and safe result to the consumers.