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Mifepristone followed in 24 hours to 48 hours by misoprostol for late first-trimester abortion

This article reports on a study investigating the efficacy of mifepristone and misoprostol for the termination of pregnancies in the late first trimester. This was a prospective study of 321 women seeking termination of pregnancy with gestations from 64 days to 84 days (±3 days). Women were enrolled at three sites in New York, Vietnam and India. Eligible women received 800 mcg of misoprostol vaginally between 24 hours and 48 hours after administration of 200 mg mifepristone. Two additional doses of 400 mcg of misoprostol were administered either orally or vaginally as needed every 3 hours for a maximum of two additional doses (total 1,600 mcg). Eighty-nine percent of women who completed the study successfully terminated their pregnancies.