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Plasma cell mucositis is a chronic, multifocal, non-neoplastic plasma cell proliferative disease of upper aerodigestive tract having unknown etiology, very rare condition with less than 50 cases reported in literature till now. The present case reported unifocal variant of such lesion of lower lip in elderly female patient presenting clinically as painless papular growth of oral commisure having nodular mucosal horns with erythematous to velvety surface changes extending towards lower lip since last one year associated with pain and pharyngitis. The histopathologic Section shows overlying squamous epithelium with marked acanthosis, hyperkeratosis and papillomatosis along with patchy fibrosis and dense plasma infiltrate.The significance of this case is the differentiation of a benign disease from one that is potentially life threatening.