Alternate Names for Recombinant Mouse sFRP-4 Protein, CF

Background

Secreted
Frizzled Related Protein-4 (sFRP-4), also known as DDC-4, FrpAP, frpHE and
FrzB-2, belongs to a family of Wnt-binding proteins with homology to the
ligand-binding domain of the Frizzled receptors (1, 2). The sFRP proteins are approximately 30-35 kDa
in size and contain an N-terminal Frizzled-like domain with 10 conserved
cysteines and a Netrin-like C-terminal domain (1-3). Of all the sFRPs, sFRP-4
is most closely related to sFRP-3 (1). Mature mouse sFRP-4 shares 92% and 96% amino acid (aa) sequence identity with human and rat sFRP-4, respectively.
sFRP-4 is expressed in brain, kidney, lung, ovary, prostate, mammary gland, and
endometrium (1, 2). This protein shows complex functions with respect to cell
survival: it is up‑regulated with apoptosis during ovulation (3), regulates
apoptosis in chondrocytes (4), and promotes apoptosis in mammary glands when
expressed in transgenic mice (5). On the other hand, sFRP-4 can also act to
enhance growth as it is up‑regulated in endometrial and breast carcinomas
(6, 7). Since it is not detected in other carcinomas such as the ovary,
colon, and pancreas, its role in cancer is likely to be tissue
dependent (6). In addition, sFRP-4 is characterized as a circulating
phosphaturic factor expressed by tumors associated with osteomalacia that
antagonizes renal Wnt signaling (8).

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