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Research led by St. Jude Children’s Research Hospital investigators used a pioneering approach to drug development and identified dozens of potential new treatments of ependymoma, a rare tumor of the brain and spinal cord.

International effort led by St. Jude Children’s Research Hospital scientists is expected to fuel development of targeted therapies and aid the search for unique combinations of cells and mutations that lead to other cancers

Scientists have long recognized that cancers may look the same under the microscope, but carry different mutations, respond differently to treatment and result in vastly different outcomes for patients.

Whenever family and friends are invited to your home, chances are the evening will end with everyone lingering in the kitchen. Perhaps someone has a warm pot of coffee to share, a story or a hearty laugh. Whatever the attraction, the heart of the home beats strongest when everyone joins together. At St. Jude Children’s Research Hospital, the Chemical Biology and Therapeutics (CBT) department serves a similar role.

St. Jude researchers launch a counterattack on pediatric cancer using molecular-targeted therapy. As scientists learn more about the human genome and specific genetic mutations, they are finding new strategies to ambush the enemy.

The discovery that expression of specific genes can accurately report the presence of mutations in biochemical pathways within medulloblastoma cells could speed development of more effective and less toxic treatments.

Ependymomas that occur in different parts of the central nervous system appear to arise from different subpopulations of stem cells. The discovery explains why some identical-looking ependymomas are actually distinctly different diseases...