Consent

Objectives

The purpose of this study was to compare the relative beneficial and systemic effects in a dose-response relationship for 2 ICSs.

Background

A clinical model is needed to compare inhaled corticosteroids (ICS) with respect to efficacy.

Subjects

30 asthmatic individuals 18 to 55 years of age. This was a feasibility study, not a comparative trial, therefore the sample size calculation was based on an appropriate sample size for estimating the common variance with some level of precision.

Conclusions

High-dose ICS therapy did not significantly increase the efficacy of measures that were evaluated but it did increase the systemic effect measure, overnight cortisol secretion.

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Study Documents

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