However, it is important to differentiate a lipoma from an atypical lipomatous tumor, which may have a similar appearance but, unlike a lipoma, can on occasion develop into a cancer (your brother should see an orthopaedic or surgical oncologist if he has any concerns).

In addition, these markers are often helpful in the distinction between benign lipomas, particularly those with prominent fat necrosis, and atypical lipomatous tumor (well-differentiated liposarcoma), particularly when the latter shows very minimal atypical histologic features.

Tumors meeting the classic histopathologic criteria for WDLs that arise in the oral cavity, salivary glands, and other superficial, surgically accessible areas are called atypical lipomatous tumors (ALTs).

In these 10 sections, the authors discuss the general information for each tumor in detail and also include some interesting topics in relevant sections, such as the reasons for retaining the category of fibrous histiocytomas, spindle cell/pleomorphic lipoma versus atypical lipomatous tumors, and problematic smooth muscle tumors of the soft tissues and retroperitoneum.

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