In order to explore the influence of seismic motion characteristics on sand compression and propose a reasonable evaluation method of sand seismic compression, this paper used the open source finite element platform OpenSees to simulate the seismic compression of sand, and the influence of seismic dimension and directionality on the compression of saturated sand is studied. Using the seismic collapse ratio as the evaluation index, the rationality of the simple one-way load to simplify the two-dimensional load is analyzed, and the correlation between seismic compression and seismic load parameters is studied. Finally, a method for calculating the saturated sand compression which considers the characteristics of seismic motion is proposed. The results show that the pore water pressure and the seismic compression of the saturated sand under horizontal bidirectional seismic load are larger than horizontal unidirectional loading results, but less than the sum of the result of the two unidirectional load and twice the result of any unidirectional loading. The direction of the seismic motion has a significant effect on the seismic subsidence ratio, and the maximum sag ratio obtained by different seismic motion is dissimilar from the corresponding angle. It is not reasonable to use a one-dimensional load of a certain direction to simplify the analysis of two-dimensional loads. The correlation between the seismic load and it’s strength parameter Sa (0.6 s) and VSI is good, and the prediction formula which uses VSI as a parameter can quickly calculate the amount of seismic; the greater the relative density of sand, the more accurate the calculation results.