Manufacturers and importers: - to register substances they produce or import in quantities over 1 tonne per year. The registration requirement applies to substances on their own, in preparations and in articles under special conditions (intentional release). Failure to register means that the substance cannot be manufactured, imported or used in the EU market.

Downstream users of chemicals:
- to apply the risk management measures for dangerous substances identified on the supplier Safety Data Sheets. They have a right to make their use of a substance known to the manufacturer in order to make it an identified use and have it covered in their supplier's chemical safety assessment. In this case they have to provide sufficient information to allow the supplier to prepare an exposure scenario for the use.
- alternatively, to conduct own chemical safety assessment and report to the chemicals agency.