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Discontinuation syndrome Group of symptoms that occurs upon the abrupt discontinuation/withdrawal of anti-depressants Group of symptoms that occurs upon the abrupt discontinuation/withdrawal of anti-depressants Higher risk for agents with the shorter half-lives and inactive metabolites Higher risk for agents with the shorter half-lives and inactive metabolites In tricyclics, discontinuation syndrome symptoms include anxiety, insomnia, headache, nausea, malaise, or motor disturbance In tricyclics, discontinuation syndrome symptoms include anxiety, insomnia, headache, nausea, malaise, or motor disturbance