Data show that Crlz1 increased the IgJ enhancer activity due to its CBF sites, as verified by both the absence of Crlz1 effect on the CBF-site mutated IgJ enhancer and the presence of transcriptional synergy between Crlz1 and CBFbeta.

identifies the HSS3/4 enhancer of Crlz1 (zeige UTP3 ELISA Kits)-IgJ locus as another target of EBG in early developmental stage of B cells

H3 and H4 histones toward the chromatin of the Crlz1 (zeige UTP3 ELISA Kits) gene are found to be hyperacetylated, especially on H3, in the pre-B cells, whereas those toward the chromatin of the IgJ gene are found to be hyperacetylated in the plasma cells

IGJ Antigen-Profil

Beschreibung des Gens

Serves to link two monomer units of either IgM or IgA. In the case of IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer, and in the case of IgA it induces larger polymers. It also help to bind these immunoglobulins to secretory component.