Obesity is a complicated global health problem which needs to be treated. The main problem is the corruption of energy balance in favor of nutrient intake and storage. Ghrelin is one of the hormones which are thought to have the greatest impact on energy balance. However, there has not yet been accurately described a mechanism between the morbid obesity and ghrelin hormone. Plasma ghrelin level is low in obese and high in lean people. The aim of this study is to determine histopathological changes in stomach of morbid obesity and to evaluate the ghrelin-expressing cells and the distribution of endocrine cells. Furthermore, this study also aims to compare the ghrelin expression of obese patients with various parameters such as age, gender, BMI, level of preoperative plasma ghrelin and presence of additional diseases. The study included 33 morbidly obese patients and 8 non-obese control patients. Sleeve gastrectomy resection materials of 33 cases were evaluated with the histopathological and immunohistochemical (ghrelin and chromogranin) techniques and plasma ghrelin levels were measured. Histopathological findings found in this study: interstitial lymphocytic infiltration rate of 63.6%, hyperplasia of lymphoid follicles in the lamina propria in 60.7% and microvesiculation / dilatation of parietal cells in 57.6%. There was no significant correlation found between ghrelin-chromogranin immunopositive cell distribution and preoperative plasma ghrelin levels-endocrine cell hyperplasia in the immunohistochemical examination of chromogranin that has been done to evaluate the distribution of endocrine cells. However, numbers of ghrelin immunopositive cells were significantly higher at proximal corpus compared to those in distal corpus of the stomach. Additionally, the numbers of ghrelin immunopositive cells in gastric mucosa in females are found to be significantly higher compared to males. However, new researches should be done in order to prove that gender can be an important factor in determining the choice of surgical procedure in treatment of morbid obesity.