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Ratchet and Clank: Up Your Arsenal, the third game in the series, was released on November 2, 2004 in North America and on November 12 in Europe. The heroes need to stop an evil robot, Dr. Nefarious and the Thyrranoid race, from killing all organic life in the galaxy and turning everyone into robots (so they can rule the universe). To learn how to defeat Dr. Nefarious, the duo need to locate the only man who has ever defeated him, which soon leads them to join a team of characters who work together to take Nefarious down and save the universe once again. The game is proceeded by Ratchet: Deadlocked.

This is the third installment of the Ratchet and Clank series. Clank is now a star of is own TV series "Secret Agent Clank", with Ratchet taking a backseat from the spotlight. When their home planet of Veldin is under attack from the evil Dr. Nefarious, the duo is sent by the Galactic pres. to find and form a team of unlikely heroes including returnees Skidd McMarxx, Helga, Captain Qwark, and Big Al.R atchet'll be able to train, purchase weapons, and receive missions.

Ratchet and Clank once again team up for an all-new adventure combining diverse gameplay with elements of action, exploration, co-op vehicles, adventure, puzzle-solving, strategy, role-playing and fierce battles into one riveting experience. Featuring single-player and introducing new multiplayer offline and online gameplay, Ratchet & Clank: Up Your Arsenal aims to redefine the action platform genre even further to deliver one of the most exciting and fulfilling single-player and multiplayer experiences ever.