Diverse long interspersed element-1 (LINE-1 or L1)-dependent mutational mechanisms have been extensively studied with respect to L1 and Alu elements engineered for retrotransposition in cultured… (More)

Autosomal dominant polycystic kidney disease (ADPKD) is heterogeneous with regard to genic and allelic heterogeneity, as well as phenotypic variability. The genotype-phenotype relationship in ADPKD… (More)

Although gross insertions (>20 bp) comprise <1% of disease-causing mutations, they nevertheless represent an important category of pathological lesion. In an attempt to study these insertions in a… (More)

Autosomal dominant polycystic kidney disease (ADPKD), the most common inherited kidney disorder, is caused by mutations in PKD1 or PKD2. The molecular diagnosis of ADPKD is complicated by extensive… (More)

Genomic rearrangements are a well-recognized cause of genetic disease and can be formed by a variety of mechanisms. We report a complex rearrangement causing severe hemophilia A, identified and… (More)

ETHNOPHARMACOLOGICAL RELEVANCE
In China, over 20 Salvia species have been used as Danshen in traditional folk medicine for the treatment of coronary heart diseases and strokes.
AIM OF THE STUDY
In… (More)

Phytase is widespread in nature. It has been used as a cereal feed additive that can enhance the phosphorus and mineral absorption in monogastric animals to reduce the level of phosphorus output in… (More)

The 3′ regulatory regions (3′ RRs) of human genes play an important role in regulating mRNA 3′ end formation, stability/degradation, nuclear export, subcellular localization and translation and are… (More)