Target Details DFFA

Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis.Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

References for anti-DFFA Antibody (ABIN2779329)

Yan, Fu, Li, Blechl, Tranquilli, Bonafede, Sanchez, Valarik, Yasuda, Dubcovsky: "The wheat and barley vernalization gene VRN3 is an orthologue of FT." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, Issue 51, pp. 19581-6, 2006

Yan, Wang, Peng, Hu, Wang, Zhang, Chen, Bedford, Dewhirst, Li: "A unique role of the DNA fragmentation factor in maintaining genomic stability." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, Issue 5, pp. 1504-9, 2006