A novel rat contact lens model for Fusarium keratitis. (Volume 19) - Abou Shousha, MohamedThis article is from Molecular Vision, volume 19.AbstractPurpose: The aim of this study was to develop and characterize a new contact lens–associated fungal keratitis rat model and to assess the ability of non-invasive spectral-domain optical coherence tomography (SD-OCT) to detect pathological changes in vivo in fungal keratitis. Methods: We used SD-OCT to image and measure the cornea of Sprague Dawley rats...Downloads: 10

S100A4 is upregulated in proliferative diabetic retinopathy and correlates with markers of angiogenesis and fibrogenesis. (Volume 20) - Abu El-Asrar, Ahmed M.This article is from Molecular Vision, volume 20.AbstractPurpose: The calcium-binding protein S100A4 is implicated in cancer cell invasion and metastasis, the stimulation of angiogenesis, the progression of fibrosis, and inflammatory disorders. We investigated the expression of S100A4 and correlated it with clinical disease activity as well as with the levels of osteopontin (OPN), soluble syndecan-1, and vascular endothelial growth factor (VEGF) in proliferative diabetic retinopathy (PDR)...Downloads: 9

Decreased total antioxidants status in the plasma of patients with pseudoexfoliation glaucoma. (Volume 17) - Abu-Amero, Khaled K.This article is from Molecular Vision, volume 17.AbstractPurpose: To evaluate total antioxidant status (TAS) in the plasma of pseudoexfoliation glaucoma (PEG) patients and to compare this level with a matching control group. Additionally, we aim to investigate the effect of the combined action of the lysyl oxidase-like 1 (LOXL1) mutation status with TAS level on the development of PEG. Methods: Plasma samples were obtained from 54 PEG patients and 54 controls of matching age, sex, and ethnicity...Downloads: 6

Molecular characteristics of four Japanese cases with KCNV2 retinopathy: Report of novel disease-causing variants. (Volume 19) - Fujinami, KaoruThis article is from Molecular Vision, volume 19.AbstractPurpose: To describe the molecular characteristics of four Japanese patients with cone dystrophy with supernormal rod responses (CDSRR). Methods: Four individuals with a clinical and electrophysiological diagnosis of CDSRR were ascertained. The pathognomonic findings of the full-field electroretinograms (ERGs) included a decrease in the rod responses, a square-shaped a-wave, an excessive increase in the b-wave in the bright flash responses...Downloads: 7

Two novel disease-causing mutations in the CLRN1 gene in patients with Usher syndrome type 3. (Volume 18) - Garcia-Garcia, GemaThis article is from Molecular Vision, volume 18.AbstractPurpose: To identify the genetic defect in Spanish families with Usher syndrome (USH) and probable involvement of the CLRN1 gene. Methods: DNA samples of the affected members of our cohort of USH families were tested using an USH genotyping array, and/or genotyped with polymorphic markers specific for the USH3A locus. Based on these previous analyses and clinical findings, CLRN1 was directly sequenced in 17 patients susceptible to carrying...Downloads: 5

The works of John Hunter, F.R.S. with notes (Volume v.5) - Hunter, John, 1728-1793I. Life of John Hunter, by D. Ottley. Appendix. Surgical lectures.--II. Treatise on the natural history and diseases of the human teeth, with notes by T. Bell. A treatise on the venereal disease, with notes by G. G. Babington.--III. Treatise on the blood, inflammation, and gun-shot wounds. Observations on the inflammation of the internal coats of veins. On introsusception. An account of Mr. Hunter's method of performing the operation for the cure of popliteal aneurism, by Sir E...Keywords:Hunter, John, 1728-1793; Medicine; Medicine; General SurgeryDownloads: 111

The works of John Hunter, F.R.S. with notes (Volume v.3) - Hunter, John, 1728-1793I. Life of John Hunter, by D. Ottley. Appendix. Surgical lectures.--II. Treatise on the natural history and diseases of the human teeth, with notes by T. Bell. A treatise on the venereal disease, with notes by G. G. Babington.--III. Treatise on the blood, inflammation, and gun-shot wounds. Observations on the inflammation of the internal coats of veins. On introsusception. An account of Mr. Hunter's method of performing the operation for the cure of popliteal aneurism, by Sir E...Keywords:Hunter, John, 1728-1793; Medicine; Medicine; General SurgeryDownloads: 171

The works of John Hunter, F.R.S. with notes (Volume v.2) - Hunter, John, 1728-1793I. Life of John Hunter, by D. Ottley. Appendix. Surgical lectures.--II. Treatise on the natural history and diseases of the human teeth, with notes by T. Bell. A treatise on the venereal disease, with notes by G. G. Babington.--III. Treatise on the blood, inflammation, and gun-shot wounds. Observations on the inflammation of the internal coats of veins. On introsusception. An account of Mr. Hunter's method of performing the operation for the cure of popliteal aneurism, by Sir E...Keywords:Hunter, John, 1728-1793; Medicine; Medicine; General SurgeryDownloads: 138

The works of John Hunter, F.R.S. with notes (Volume V.1) - Hunter, John, 1728-1793I. Life of John Hunter, by D. Ottley. Appendix. Surgical lectures.--II. Treatise on the natural history and diseases of the human teeth, with notes by T. Bell. A treatise on the venereal disease, with notes by G. G. Babington.--III. Treatise on the blood, inflammation, and gun-shot wounds. Observations on the inflammation of the internal coats of veins. On introsusception. An account of Mr. Hunter's method of performing the operation for the cure of popliteal aneurism, by Sir E...Keywords:Hunter, John, 1728-1793; Medicine; Medicine; General SurgeryDownloads: 215

The works of John Hunter, F.R.S. with notes (Volume V.4) - Hunter, John, 1728-1793I. Life of John Hunter, by D. Ottley. Appendix. Surgical lectures.--II. Treatise on the natural history and diseases of the human teeth, with notes by T. Bell. A treatise on the venereal disease, with notes by G. G. Babington.--III. Treatise on the blood, inflammation, and gun-shot wounds. Observations on the inflammation of the internal coats of veins. On introsusception. An account of Mr. Hunter's method of performing the operation for the cure of popliteal aneurism, by Sir E...Keywords:Hunter, John, 1728-1793; Medicine; Medicine; General SurgeryDownloads: 206

Mutation screening of the PCDH15 gene in Spanish patients with Usher syndrome type I. (Volume 18) - Jaijo, TeresaThis article is from Molecular Vision, volume 18.AbstractPurpose: PCDH15 codes for protocadherin-15, a cell-cell adhesion protein essential in the morphogenesis and cohesion of stereocilia bundles and in the function or preservation of photoreceptor cells. Mutations in the PCDH15 gene are responsible for Usher syndrome type I (USH1F) and non-syndromic hearing loss (DFNB23). The purpose of this work was to perform PCDH15 mutation screening to identify the genetic cause of the disease in a cohort ...Downloads: 9

p53 E3 ubiquitin protein ligase homolog regulates p53 in vivo in the adult mouse eye lens. (Volume 19) - Jaramillo-Rangel, GilbertoThis article is from Molecular Vision, volume 19.AbstractPurpose: p53 is a transcription factor that plays an important role in preventing cancer development. p53 participates in relevant aspects of cell biology, including apoptosis and cell cycle control and must be strictly regulated to maintain normal tissue homeostasis. p53 E3 ubiquitin protein ligase homolog (Mdm2) is an important negative regulator of p53...Downloads: 5

Chlamydia infection status, genotype, and age-related macular degeneration. (Volume 18) - Khandhadia, SamThis article is from Molecular Vision, volume 18.AbstractPurpose: To evaluate whether Chlamydia (C.) infections are associated with age-related macular degeneration (AMD) and to assess if this association is influenced by the complement factor H (CFH) Y402H or the high temperature requirement A serine peptidase 1 (HTRA1) rs11200638 risk genotypes. Methods: One hundred ninety-nine AMD patients with early and late forms of the disease and 100 unaffected controls, at least 50 years old were include...Downloads: 3

Amelioration of endotoxin-induced uveitis treated with an I?B kinase ? inhibitor in rats. (Volume 18) - Lennikov, AntonThis article is from Molecular Vision, volume 18.AbstractPurpose: Endotoxin-induced uveitis (EIU) is an animal model for acute ocular inflammation. Several substances play major roles in the development of inflammatory changes in EIU, including tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, and IL-6. These inflammatory cytokines trigger the degradation of IκB by activating IκB kinases (IKKs)...Downloads: 4

Amelioration of endotoxin-induced uveitis treated with the sea urchin pigment echinochrome in rats. (Volume 20) - Lennikov, AntonThis article is from Molecular Vision, volume 20.AbstractPurpose: Echinochrome is a pigment present in the shells and spines of sea urchins. It has been reported to have several biologic protective effects, including in experimental models of myocardial ischemia/reperfusion injury, for which the proposed mechanisms are scavenging reactive oxygen species (ROS) and chelating iron. Endotoxin-induced uveitis (EIU) is an animal model of acute anterior segment intraocular inflammation that is induced ...Downloads: 2

SOD2 contributes to anti-oxidative capacity in rabbit corneal endothelial cells. (Volume 17) - Liu, CailingThis article is from Molecular Vision, volume 17.AbstractPurpose: Corneal endothelial cells are rich in mitochondria, a potential source of reactive oxygen species (ROS). ROS have been implicated in endothelial cell loss during aging or in endothelial dystrophies. In this study we examined the anti-oxidative role of mitochondrial superoxide dismutase (SOD2) in corneal endothelial cells. Methods: SOD2 expression was examined by RT–PCR and western blot analysis in fresh rabbit corneal endotheliu...Downloads: 4

Association of paired box 6 with high myopia in Japanese. (Volume 18) - Miyake, MasahiroThis article is from Molecular Vision, volume 18.AbstractPurpose: The objective of this study was to investigate whether genetic variations in the paired box 6 (PAX6) gene are associated with high myopia in Japanese subjects. Methods: A total of 1,307 unrelated Japanese patients with high myopia (axial length ≥26 mm in both eyes) and two independent control groups were evaluated (333 cataract patients without high myopia and 923 age-matched healthy Japanese individuals)...Downloads: 6

The genetic control of avascular area in mouse oxygen-induced retinopathy. (Volume 18) - O'Bryhim, Bliss E.This article is from Molecular Vision, volume 18.AbstractPurpose: The C57BL/6ByJ and BALB/cByJ inbred strains of mice are, respectively, susceptible and resistant to oxygen-induced retinopathy (OIR). The purpose of this work was to investigate the genetic control of the retinal avascular area in mouse OIR using a mapping cross. Methods: The central retinal avascular area was measured on postnatal day 16 (P16) in C57BL/6ByJ, BALB/cByJ, 101 (C57BL/6ByJ x BALB/cByJ)F2, and 116 (BALB/cByJ x C57BL/6B...Downloads: 3