Number of participants with Adverse Events as a Measure of Safety and Tolerability [ Time Frame: single dose administration (baseline) and 1 post-treatment follow up week ] [ Designated as safety issue: Yes ]

Evaluate the tolerability and safety of single dose intravenous administration

Secondary Outcome Measures:

Pharmacokinetic and Pharmacodynamic parameters [ Time Frame: single adminsitration (baseline) and 1 week of follow up ] [ Designated as safety issue: No ]

Obtain pharmacokinetic parameters before and after CT-1 single dose administration.

Ability to communicate well with the investigator and to comply with the requirements of the entire study.

Willingness to give written informed consent (prior to any study-related procedures being performed) and to be able to adhere to the study restrictions and examination schedule.

For female subjects with childbearing potential: use of a known highly effective method of birth control, defined as those which results in a low failure rate: i.e. less 1% per year, (contraceptive pills, intrauterine contraceptive device, implants, vasectomized partner or sexual abstinence), for at least three consecutive months prior to the study, during the study and one month after the end of the study.

For male subjects with partners of child bearing potential: use of appropriate contraceptive methods (vasectomy, condoms or sexual abstinence), for at least the study period and one month after the end of the study.

Exclusion Criteria:

Administration of any investigational drug in the period within three months prior to informed consent.

Use of any prescription medication during the period 0 to 30 days or over-the-counter medication during the 0 to 5 days before entry to the study.

Donation or loss of greater than 400 ml of blood in the period 0 to 12 weeks before entry to the study.

Serious adverse reaction or hypersensitivity to any drug.

Inability to communicate or co-operate with the investigator because of a language problem, poor mental development or impaired cerebral function.

History of drug dependence (except tobacco) or psychiatric illness within the past 2 years.

Consumption of alcohol within 24 hours prior to dose administration.

Presence of pain incurred by unknown causes.

Pregnancy or nursing.

Positive urine drug screen for drugs with a high potential for abuse and low persistence in the urine.

Inability to refrain from smoking during study days.

Any other condition which, in the opinion of the investigators, is likely to interfere with the successful collection of the measures required for the study.

Contacts and Locations

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study.
To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below.
For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01334697