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A 78-year-old male was admitted to a rehabilitation facility with the diagnosis of Guillain-Barré syndrome. He initially developed numbness and tingling in bilateral feet and lower legs that progressed to his hands and arms over a 3-day period. Upon visiting his primary care physician, he was transferred directly to the hospital for further monitoring. He underwent a spinal tap and nerve conduction velocity test, ultimately leading to a diagnosis of Guillain-Barré syndrome. While in the hospital for 3 weeks, he developed complete bilateral lower extremity paralysis with decreased sensation. He developed some upper extremity weakness, but maintained at least a grade of 3/5 for all upper extremity muscles. His pulmonary and respiratory function remained adequate and he did not require mechanical ventilation. After the third week, his signs and symptoms began to plateau and he started to regain minimal motor function. The patient was then transferred to an inpatient rehabilitation facility (IRF). At admission to the IRF, the physical therapist is asked to evaluate and treat the patient to improve functional mobility and independence to enable a discharge home with his wife to a one-story home with level-entry access.