Endosialin is a potential regulator of phenotypic remodeling of vascular smooth muscle cells contributing to atherosclerosis.

suggest that CD248 stromal cells have a pathogenic role in renal fibrosis

We conclude that CD248 is required for PDGFRbeta-dependant capillary sprouting but not splitting angiogenesis, and identify a new role for CD248 expressed on pericytes in the early stages of physiological angiogenesis during muscle remodelling.

The authors show that endosialin, a C-type lectin (show MBL2 ELISA Kits), expressed in the liver exclusively by HSC (show FUT1 ELISA Kits) and portal fibroblasts, is upregulated in liver fibrosis in mouse and man.