Elizabeth Stringer Keefe's work has focused on the preparation and training of teachers who work with students with autism spectrum disorder (ASD) and severe disabilities. She began her career as a special educator in public and private settings and continues to consult to Massachusetts public school districts and community agencies that support students with ASD. Her work has informed the development and revision of several academic programs as well as professional development offerings at Lesley, which include an annual conference and speaker series. These offerings provide training beyond the standard teacher licensure for educators, professional development for specialists, and training for parents. Elizabeth is a member of the Board of Directors of the Massachusetts Autism Society of America and the Massachusetts Autism Commission School-Age subcommittee. In 2006 she was honored by The Arc of Greater Boston with their Outstanding Educator Award.

Keefe is co-president-elect of the Massachusetts Council for Exceptional Children (CEC). Her term begins in 2017, which is also the year the national CEC will hold its convention in Boston.