Cavani is a versatile striker who, despite his size, can move all around the attacking positions, and even play as an attacking midfielder. Nevertheless, his natural position is centre-forward.

He debuted with national team in February 2008, in a friendly match against Colombia. He played fifteen minutes and scored a goal. During the 2010 World Cup wualifiers he played seven matches, but only one as a starter.

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His idol in football is his older brother Walter Guglielmone, formerly of Nacional, who currently plays in Azerbaijan.