T-cell receptor

T-cell re·cep·tor

(TCR) (sel rĕ-sep'tŏr)

An adhesion molecule on the membrane of T lymphocytes, which serves as the receptor for antigen bound to antigen-presenting cells (APC) through MHC molecules. It is expressed in a complex with CD3. It is in proximity to the MHC-restricted receptor (CD4 or CD8). Synonym(s): T-lymphocyte antigen receptor.

T-cell receptor

Abbreviation: TCR

One of two polypeptide chains (a or ß) on the surface of T lymphocytes that recognize and bind foreign antigens. TCRs are antigen specific; their activity depends on antigen processing by macrophages or other antigen-presenting cells and the presence of major histocompatibility complex proteins to which peptides from the antigen are bound.

United Kingdom-based GSK has exercised the option to receive an exclusive global license from Adaptimmune for an investigational SPEAR T-cell receptor therapy aimed at tumour antigen, NY-ESO-1 (GSK3377794), it was reported on Friday.

The latest results supporting this optimism are new data indicating that scavenger cells called macrophages secrete a chemical that disintegrates other cells and McFarlin's preliminary discovery that multiple sclerosis patients have a "peculiar pattern of T-cell receptor gene.

The Novartis Prize for Basic Immunology 2016 is shared by John Kappler (National Jewish Health, USA), Philippa Marrack (National Jewish Health, USA) and Harald von Boehmer (Emeritus, Harvard Medical School, USA) for their work in demonstrating how the immune system is able to discriminate "self" from "non-self" through a process in the thymus based on positive and negative selection via T-cell receptor mediated recognition of peptide-MHC complexes.

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