Perkins is a HTML5/CSS-powered framework for building websites quicker and easier. It comes with a simple template which includes most of the supported tags and a set of LESS stylesheets + mixins for popular items like navigation, rounded corners, gradients and more. All of the items (typography, forms, tables, buttons, etc.) are styled very nicely and there is a @font-face icon set included for instant-inline icons.

HTML5 Boilerplate is a professional base HTML/CSS/JS template for a fast, robust and future-proof site. It promises the best of the best practices baked in: cross-browser normalization, performance optimizations, even optional features like cross-domain Ajax and Flash. A starter apache .htaccess config file hooks you the eff up with caching rules and preps your site to serve HTML5 video, use @font-face, and get your gzip zipple on.

320 and Up is designed first for the small screen, and implement the layout working upwards in size. 320 and up contains Media Query increments for five viewport sizes, a vertical grid, preset styles for typography and components from HTML5 Boilerplate.

The 1140 CSS Grid takes the opposite approach of the 320 and up system. This is primarily aimed at people who really want to design for a wider 1280 pixel screen, and are sick of catering to a 1024 pixel baseline. 1140 CSS Grid allows them to do that while fluidly re-arranging to fit on smaller screens all the way down to mobile.

Isotope is an exquisite jQuery plugin for magical layouts. Enables filtering, sorting, and dynamic layouts. Isotope’s capabilities are designed to be used together cohesively. You can do it all — filter, sort, change layout modes, add items — and Isotope will handle it with ease.