The NFL season is still weeks away, but that hasn’t stopped fantasy football owners from drafting their teams already. And there are plenty of people likely regretting that decision as of today. Fantasy football already looks different than it did last week, and here are some of the biggest injuries that will have a negative impact on owners in 2017. Click here for a full list of injuries that have occurred so far this preseason.

Tannehill is out for the season after suffering a non-contact knee injury, and this affects two-quarterback leagues and deeper fantasy leagues the most. Miami’s man under center had less than 3,000 passing yards to go with 19 touchdowns and 12 interceptions in 2016. Tannehill’s stat line is underwhelming, but again, deeper leagues often rely on points where they can take them, and he was fairly consistent.

The current situation in the Broncos’ backfield is almost reminiscent of last season — an utter mess. Booker was off and on in 2016, but was expected to be the starter heading into the season before suffering a hairline fracture in his wrist and undergoing surgery. Reports are that he should be back by Week 2, but this is a crowded backfield to put it mildly.

Luck’s situation started at the end of the 2016 season, but if you haven’t drafted yet, don’t fall for taking Luck early. It is unclear when the Colts’ quarterback will be ready to play following his shoulder injury, but be leery of relying on Luck this season. Allow other owners to not heed warnings about Luck, as his ADP is still sitting around 5.0 according to Fantasy Pros.

Sankey suffered a torn ACL against the Buffalo Bills in the Vikings’ first preseason game and has been placed on injured reserve. The running back was one of several vying for carries in another crowded backfield, but has since been placed on the waived-injured list. There are other decent options in the Minnesota rushing attack in Latavius Murray and Jerick McKinnon.

Unlucky Player of the Year

Fantasy owners were hoping that this was the year that Fuller would show how good he can be, but the young receiver is on injured reserve once again. This marks the second consecutive season that Fuller is on IR, and is a harsh reality that sports isn’t always kind to players.

Biggest Benefactor: NFC South defenses

While this list will likely grow over the course of the next few weeks, these names need to be avoided by fantasy owners who have not drafted yet.