The prognostic effects of pregnancy subsequent to breast cancer in young (#569)

Aim:To understand the status of pregnancy after breast cancer treatment and evaluate its effects on disease progression and
survival in breast cancer patients.

Methods:This study involved 176 patients,which was conducted to compare prognosis among breast cancer patients with or without a subsequent pregnancy in Tianjin Cancer Hospital between January 2003 and December 2007.The median follow-up period was 74
months. The pregnancy
status, clinical and pathological characteristics were included and analyzed by
statistical software SPSS19.0 to calculate the relation with disease-free
survival and overall survival. The clinical data were described by the
percentage, Kaplan-Meier method for calculation of survival, Log-Rank method
for the univariate factor analysis, COX model for multivariate factors
analysis, and COX regression was used to estimate the hazard ratio of dying
among women with a pregnancy after breast cancer treatment compared with women
without, with p<0.05
defined as a statistically significant difference.

Results:In all, 35 patients were pregnant
after breast cancer treatment, in which 7 women experienced full term
births and 28 abortions.The 5 years overall survival was 100% for women
experienced pregnancy and 90.6% for women who did not (p=0.08). Univariate
factor analysis results showed that the tumor size, ER, HER-2, nodal status and
surgery method were related with disease free survival (p < 0.05), except the surgery method, the rest above were also
significantly related with overall survival. Multivariate factors analysis
result indicated that tumor size and surgery method were independent factors of
disease free survival,and tumor size appeared to be the only independent factor
of overall survival.Pregnancy after
breast cancer treatment implied significant protective effect on disease
progression （HR=0.22 p=0.02）compared with women who did not,however,it had no significant positive impact on overall survival（p=0.96).

Conclusions:There is no evidence that a pregnancy
after treatment of breast cancer has a negative influence the prognosis.