Squamous cell carcinoma of the lower lip (SCCLL) is a common oral
malignancy, and it develops mainly due to chronic exposure to ultraviolet (UV) radiation.
Studies have shown that overexpression of cyclooxygenase 2 (COX-2) in oral carcinomas
is associated with poor prognosis and reduced survival. Therefore, the aim of the study
was to analyze the immunoexpression of COX-2 in cases of SCCLL and verify its
association with clinicopathological parameters.