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If you are going to take a taxi, reserve one from a car rental service to pick you up at your hotel. They take people to the airport starting at 4 am. You can search the boards for a recommendation or ask on Tripadvisor message boards.

Taxis in Rome are set fees to the airport of 45E for 4 people including luggage. They might be allowed a slight surchage for night time, but it would only be a couple of euro. Just make sure you book an official Rome taxi.