Uses

Principal Proposed Uses

Many foods can cause gassiness, including beans (legumes), broccoli, cabbage, onions, and whole grains. This occurs because these foods contain complex carbohydrates that are not entirely broken down in the digestive tract, and instead serve as food for intestinal bacteria. These bacteria produce hydrogen and carbon dioxide gas as they digest the carbohydrates. While everyone develops intestinal gas to some extent, certain people have an intolerance of complex carbohydrates and develop relatively more severe symptoms.
1
Use of alpha-galactosidase has been advocated as a treatment for both complex carbohydrate intolerance and ordinary gassiness. This enzyme helps break down complex carbohydrates. When taken as a supplement, it may enhance the digestive process and thereby deprive gas-producing bacteria of fuel to work on.

Requirements/Sources

Alpha-galactosidase is ordinarily manufactured by the body and is not a nutrient. It is found in particularly high quantities in the yeast
Aspergillus niger
, the source of commercial products.

Therapeutic Dosages

Therapeutic Uses

Although alpha-galactosidase is widely marketed as an over-the-counter treatment to prevent
intestinal gas
, there is only limited evidence that it really works. In two preliminary double-blind, controlled trials enrolling a total of 39 people, use of alpha-galactosidase along with a meal of beans significantly reduced symptoms of excess gas.
2,3
Two other relevant trials were also small, and suffered from significant design flaws.
3,4
Larger and more strictly designed studies will be necessary to determine whether alpha-galactosidase is truly an effective treatment for reducing intestinal gas.

Safety Issues

Although alpha-glucosidase appears to be safe for people in normal health, there are potential concerns involving people with
diabetes
as well as those with a rare condition named galactosemia.

Alpha-glucosidase breaks down complex carbohydrates into easily absorbed sugars. This may raise blood sugar levels in people with diabetes. Drugs that block alpha-glucosidase (alpha-glucosidase inhibitors) have proven benefit for people with diabetes. One study found that use of alpha-glucosidase supplements reduced the effectiveness of the diabetes drug acarbose, an alpha-glucosidase inhibitor drug.
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For this reason, people with diabetes who are using alpha-glucosidase inhibitors should avoid alpha-glucosidase supplements. In addition, it is theoretically possible that alphaglucosidase might increase blood sugar levels in people with diabetes who are not taking alpha-glucosidase inhibitors, but this has not been thoroughly evaluated.

People with the genetic condition galactosemia should also avoid alphagalactosidase as it could, in theory, worsen symptoms of the disease.

Safety in young children, pregnant or nursing women, or people with severe liver or kidney disease has not been established.

Interactions You Should Know About

If you are taking the drugs acarbose (Precose) or miglitol (Glyset) for treatment of diabetes, use of alpha-galactosidase may decrease their effectiveness.

Revision Information

This content is reviewed regularly and is updated when new and relevant evidence is made available. This information is neither intended nor implied to be a substitute for professional medical advice. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with questions regarding a medical condition.