Mechanisms of Early Recurrence in Intracranial Atherosclerotic Disease
"MyRIAD"

Recruiting

Eligibility Criteria

Inclusion Criteria

1. Stroke defined as symptoms lasting >24 hours and associated with imaging evidence of acute ischemia in the distribution of the stenotic vessel on CT or MRI. 2. Eligible TIA defined as transient neurological symptoms lasting <24 hours, need to be: 1. accompanied by DWI abnormalities in the distribution of the stenotic artery; or 2. multiple (≥2), stereotyped events associated with unequivocal ischemic symptoms (weakness, aphasia), and attributed to the symptomatic artery. 3. IAD should involve the intracranial carotid, middle cerebral, intracranial vertebral or basilar arteries. 4. Stenosis 50-99% quantified by digital subtraction angiography (DSA), CT angiography-CTA or MR angiography-MRA tests. DSA is not required but will be used if obtained as part of clinical care. The criteria for 50-99% are: 1. CTA or DSA: measured 50-99% stenosis by WASID criteria (percent stenosis = (1-[diameter stenosis/diameter normal]) x 100%. 2. MRA: measured 50-99% stenosis or presence of a flow gap. 5. Age >30; those 30-49 years of age must also have the presence of established atherosclerotic disease in another vascular bed (coronary, extracranial carotid, peripheral) or the presence of 2 or more risk factors (hypertension, diabetes mellitus, hyperlipidemia, tobacco abuse within the last 2 years). 6. Enrollment within 21 days of symptom onset and completion of study imaging tests within 21 days of index event (stroke or TIA). 7. Provide informed consent for participation in the study.

Professionals

Education

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This project is supported in part by the NIH Specialized Programs of Translational Research in Acute Stroke (SPOTRIAS) Network, and NINDS grant 3P50NS055977 to Washington University in St. Louis School of Medicine and UT Southwestern Medical Center.