In Observance of U.S. holiday, Memorial Day, Agilent Cross Lab/ iLab Operations Software will be closed during U.S. hours on Monday May 28th, 2018. EU and APAC support coverage will remain open during this time. We will resume U.S. support hours on Tuesday May 29th, 2018. For urgent matters, please add "Urgent" to the ticket subject and we will prioritize those requests first.

MDACC High Resolution Electron Microscopy Facility (HREMF)

Overview of Services

The High Resolution Electron Microscopy Facility (HREMF) provides a resource to the scientific community at MD Anderson for high resolution imaging of cells, tissues, organs or polymers containing cancer agents. The facility is located at the Smith Research Building (South Campus) and houses a JEOL JEM-1010 transmission electron microscope (TEM), a JEOL JSM-5900 scanning electron microscope (SEM) equipped with a backscattered electron detector, a Bal-Tec Technotrade coating system, a Leica Ultramicrotome, a Leica Ultrostainer and other ancillary accessories needed to prepare samples for SEM and TEM. A technologist with histological training is available to assist researchers in defining their specific needs related to SEM and TEM. Both electron microscopes are equipped with digital cameras. The facility operates on a charge-back basis only for processing of samples and the number of microscope hours used to screen samples with technical assistance.

Scanning electron micrograph of the coronary microvasculature of a mouse that has been treated with a small molecule tyrosine kinase inhibitor of platelet-derived growth factor receptor beta. Image courtesy of Dr. Aarif Khakoo.

Scanning electron micrograph of gold nanoparticles localizing to the microcirculation of an experimental model of breast cancer. The blood vessel lumen contains several red blood cells and the nanoparticles are the small white structures.

For routine TEM imaging of cell and tissue structure and subcellular ultrastructure.

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Exosome Characterization Studies

Hourly Rate

Morphological, size, and protein assessment (immunogold labeling). Provides valuable information regarding sample purity and gives an overview of the level of contamination of the sample, for example with larger vesicles, such as microparticles, apoptotic bodies or cell debris.

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Miscellaneous Charge

Exact charge will be dependant upon the specifics of your request.

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Monitoring Autophagy

Hourly Rate

TEM analysis for detection of autophagy and quantification of autophagic accumulation.

For routine TEM imaging of cell and tissue structure and subcellular ultrastructure.

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Exosome Characterization Studies

Hourly Rate

Morphological, size, and protein assessment (immunogold labeling). Provides valuable information regarding sample purity and gives an overview of the level of contamination of the sample, for example with larger vesicles, such as microparticles, apoptotic bodies or cell debris.