The primary endpoint of the BREATHE study is the apnea-hypopnea index (AHI) at one month for two groups of patients: those diagnosed with central apnea (highly prevalent in heart failure) and those with obstructive apnea.

Muscle sympathetic nerve traffic, which reflects peripheral sympathetic activity, is inhibited during the first phase of the obstructive apnea, gradually increases during the second phase followed by a strong inhibition during the last phase.

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