Are General Relativity and Quantum Mechanics incompatible? Each in their world, that of the infinitely large and that of the infinitely small, they did not seem to interfere as long as they avoided each other. However, it is their fundamental oppositions that prevent the scientific community from achieving a unification of physics. The proposal of this paper is to provide a mathematical proof of incompatibility, beyond the fact that they have fundamentally different principles, between the foundations of General Relativity and Quantum Mechanics, namely, the deformation of the space-time geometry and the Uncertainty Principle. It will thus be possible to provide an absolute limitation in establishing a unifying theory of physics, if any. Moreover, while respecting the conditions fixed by the Uncertainty Principle, it will be tempted to determine with accuracy and simultaneity, the position and the speed of a nonrelativistic particle, by application of relativistic principles and bypassing the problems raised by such an operation. The Uncertainty Principle as stated by Werner Heisenberg will be then, in the light of observations made on the measurement of the time dilatation and in accordance with its own terms, refuted by the present.