Complete IDE, very well integrated with PyQT development, but usable for any kind of project. Supports projects, debugging, auto-complete, syntax coloring, etc. It is extensible via plug-in system. It has interfaces to Subversion and Mercurial.

A general purpose developer's text editor written in Python/wxPython. It supports python syntax highlighting, auto-ident, auto-completion, classbrowser, and can run scripts from inside the editor. Extensible with plugins written in python.

Komodo is an award winning Python IDE from ActiveState. Fully-integrated Python Python 2.x and Python 3 support featuring code intelligence with autocomplete and calltips, Python debugger (includes remote debugging), interactive shell, remote file support, macros, templating, emacs command support and great help documentation. There is also an open-source version called Komodo Edit (Source), as part of the Open Komodo project started November 2007.

Open-source Python IDE focused on interactivity and introspection, which makes it very suitable for scientific computing. Its practical design is aimed at simplicity and efficiency. Pyzo consists of two main components, the editor and the shell, and uses a set of pluggable tools to help the programmer in various ways: e.g. source structure, interactive help, workspace, file browser (with functionality for searching). Also includes a post-mortem debugger.

Highly active IDE project. It offers pretty much everything: syntax highlighting, auto-indentation, code browser, debugging with breakpoints, project browser, code completion, refactoring and tooltips (with rope library installed; for a local installation on Linux, just add unpacked folder to the Pythonpath with the integrated path manager in the tools menu). Especially suitable for scientific programming as it offers an interface similar to Matlab, with integrated consoles, variable browsing and manipulation. For Windows it is conveniently integrated in the Python(x,y) distribution.

Great Cocoa editor with Python support including syntax coloring, integrated documentation, and a runtime wrapper with hyperlinked tracebacks. Note that code-folding of classes is currently broken for PEP 8 compliant code.

"Host, run, and code Python in the cloud!" Free and paid plans include access to multiple versions of CPython, PyPy, IPython notebooks, a large selection of third-party modules, bash and MySQL shells, and more.