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So much has happened since the 49ers’ 30-22 season-opening win in Green Bay on Sept. 9, the game hardly seems relevant. Nevertheless it still stands as the 49ers’ most impressive regular season win of this season and maybe of the last several seasons.

Considering the Packers were picked by many to go to the Super Bowl and the fact the 49ers beat them in Lambeau, the 49ers seem like the best team in the league after their week one win. The 49ers did play impeccably that day. Then starter Alex Smith bested his MVP counterpart Aaron Rodgers by completing 20 of 26 passes for a tidy 211 yards, no interceptions and two touchdown passes, including one to famed Packers-killer Randy Moss.

Running back Frank Gore romped for 112 yards on 16 carries including a 23-yard TD run. Colin Kaepernick even made an appearance, bolting for 17 yards out of a read option to set David Akers up for a crossbar-thumping 63-yard field goal before the close of the first half.

Since then, an injured Akers has completely lost his confidence, Smith is now Kaepernick’s understudy and plenty of players have been relegated to injured reserve. Green Bay has lost running back Cedric Benson (foot), right tackle Bryan Bulaga (hip), inside linebacker D.J. Smith (knee) and pass-rush linebacker Nick Perry (wrist). After Sunday’s win over Minnesota, the Packers anticipate placing Jerel Worthy (knee) on injured reserve.

Meanwhile, the 49ers are without wide receiver Kyle Williams (knee), wide receiver Mario Manningham (knee), running back Kendall Hunter (Achilles) defensive end Demarcus Dobbs (knee) and have a diminished defensive end in Justin Smith (triceps) and a hurting linebacker in Aldon Smith (shoulder).

This game will boil down to several factors, including which team responds best to injury. And the 49ers should watch film of their comprehensive week one win. Replaying it might provide the confidence needed to defeat the powerful Pack.