The Metropolitan Museum of Art announced Wednesday that it would no longer accept gifts from the Sackler family, principal owners of the drugmaker behind the painkiller blamed in the deadly opioid epidemic.

“The Sackler family has graciously supported The Met for 50 years and has not proposed any new contributions,” Met President and CEO Daniel Weiss said in a statement.

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“Nonetheless, in consideration of the ongoing litigation, the prudent course of action at this time is to suspend acceptance of gifts from individuals associated with this public health crisis,” he added.

On Wednesday, the American Museum of Natural History joined the Guggenheim in Manhattan in distancing themselves from the family, according to The New York Times. A spokesman for the American Museum of Natural History declined to comment.

The Met’s “review of its gift acceptance policies was precipitated in part by recent scrutiny of gifts received from individuals related to the production of opioids and the ensuing public health crisis surrounding the abuse of these medications,” the museum told The Post in a statement.

President and CEO of The Metropolitan Museum of Art Daniel WeissGetty Images

The Sacklers, whose support for the Met goes back some 50 years, said in a statement to the Times that they supported the museum’s decision.

“While we know that the allegations being made against our family are false and unfair, the last thing we would want to do is to put the Met in a difficult position, and we understand and respect their decision,” the statement said.

“Our goals has always been to support the valuable work of such outstanding organizations, and we remain committed to doing so.”

The billionaire family is named as defendants in a lawsuit announced in March by New York Attorney General Letitia James alleging that Purdue Pharma sparked the national opioid crisis by seeking profits at the expense of patient safety.

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The state — which averages nine opioid-related deaths daily — amended an existing lawsuit against Purdue Pharma to add members of its controlling Sackler family as defendants.

The lawsuit was announced two days after Purdue and the Sacklers agreed to pay $270 million to the state of Oklahoma — the first settlement among almost 2,000 lawsuits the company says could push it into bankruptcy.

In settling the case, Purdue denied any wrongdoing. The company has generated sales of more than $35 billion since debuting OxyContin in 1995, according to Forbes.

New York’s lawsuit alleges the Sacklers’ and Purdue’s aggressive marketing of OxyContin since the mid-1990s led to massive overprescriptions, addictions and deaths.