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Chapter 5: Circadian Rhythm Sleep Disorders

Etiology/Risk Factors

The etiology of DSPD is unknown although several mechanisms have been proposed. Later sleep and wake times may result from an alteration in the endogenous circadian system but are also governed by the individual’s behavior, environment, and exposure to societal pressure.1

There is evidence for a genetic basis (circadian clock gene polymorphisms)2 that can also be familial (autosomal dominant inheritance).3 Studies have also demonstrated an association between DSPD and mood and personality disorders.4