1 auto clicker should be leveling up the best hero you are most likely to be able to level up.

Place 1 auto clicker on some of the remaining skills:

Energize (to double Golden Clicks. Placed first)

Metal Detector

Lucky Strikes

Super Clicks

Powersurge

Remaining auto clickers should be also clicking the current monster.

If you are going to attempt to kill an Immortal, first move all your auto clickers to click the current monster. Make sure your skills are triggered in the correct order when you move all clickers back to their previous targets.

Mercenary quest priorities:

Mercenaries

Rubies

Relics

Hero Souls

Gold

Random Skills

Relics:

Salvage all relics that are not better than your current relics.

Use all available forge cores to upgrade your relics.

Your DPS may not increase after upgrading a relic that affects DPS. Wait or level up any hero to update your DPS.