Transcriptional regulation of nNOS is very complex and the nNOS gene produces multiple mRNA transcripts using alternate promoters, alternative splicing, cassette insertions/deletions, and varied sites for 3'-UTR cleavage and polyadenylation. Some of these alterations lead to variation in amino acid sequence, translating into nNOS isoforms with altered structural and functional properties.

nNOS has been implicated in a wide variety of physiological and pathological processes, including neurotransmission, neurotoxicity, skeletal muscle contraction, sexual function, body fluid homeostasis and atherosclerosis. Consistent with such wide involvement, nNOS is expressed in numerous tissues. The human gene encoding nNOS is localized to chromosome 12q14.

Schizophrenia PosterNew

Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. The current and emerging drug targets are also discussed.