The effect of mild therapeutic hypothermia on renal function after cardiopulmonary resuscitation in men

Abstract

Background: Mild therapeutic hypothermia (MTH) improves neurological outcome in patients after cardiac arrest. From animal and human studies it appears that hypothermia impairs renal function. The aim of this study was to examine the effects of MTH on renal function in humans. Methods: Patients were participants recruited in one of the centres of the hypothermia after cardiac arrest-multicenter trial. We measured serum creatinine and creatinine clearance (CCr) within 24h of MTH, at 4 hourly intervals. Patients were followed for acute renal failure and need for renal supportive therapy for 28 days. Results: We included 60 patients (32 hypothermic, 28 normothermic). Median serum creatinine on admission was [{119mumol/l (IQR 108-133)} {1.35mg/dl (IQR 1.22-1.50)}] in hypothermic and [{114mumol/l (IQR 99-131)} {1.29mg/dl (IQR 1.12-1.48)}] in normothermic patients, and decreased to [{69mumol/l (IQR 62-84)} {0.78mg/dl (IQR 0.70-0.95)}] in the hypothermic group and to [{88mumol/l (IQR 71-123)} {1.00mg/dl (IQR 0.80-1.39)}] in the normothermic group within 24h. CCr was decreased on admission. Within 24h CCr improved to normal values in normothermic patients [1.53ml/s (IQR 1.15-2.35) {92ml/min (IQR 69-141)}] and remained low in hypothermic patients [0.88ml/s (IQR 0.63-1.38) {53ml/min (IQR 38-83)}] (P=0.0006). No difference was found between the groups in the development of acute renal failure or the need for renal supportive therapy. Conclusion: Twenty four hours of MTH was associated with a delayed improvement in renal function. This was not reflected in the serum creatinine values, which were low in the hypothermic group. This transient impaired renal function appeared to be completely reversible within 4 weeks. 2003 Elsevier Ireland Ltd. All rights reserved.