Newell suffered a sprained knee in the three-overtime win against Northern Iowa on Aug. 31. Nwangwu suffered an apparent shoulder injury. The 1-0 Cyclones didn't have a game last Saturday.

Newell has started 13 games in a row, so him missing the game would be substantial in facing a Hawkeye team that has one of the best front fours in college football.

Both players are on the most recent depth chart -— Newell as the starter, and Nwangwu among a handful of running backs that could play.

Randy Peterson is the Iowa State columnist for the Register. Reach him at rpeterson@dmreg.com, 515-284-8132, and on Twitter at @RandyPete. No one covers the Cyclones like the Register. Subscribe today at Des Moines Register.com/Deal to make sure you never miss a moment.

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Iowa State gathers to salute their fans during their season opening game at Jack Trice Stadium on Saturday, Aug. 31, 2019 in Ames. Iowa State would go on to defeat UNI in triple overtime 29-26. Brian Powers/The Register

Iowa State head coach Matt Campbell runs off the field after beating UNI 29-26 in triple overtime of their season opening game at Jack Trice Stadium on Saturday, Aug. 31, 2019 in Ames. Brian Powers/The Register

Iowa State running back Sheldon Croney Jr. (R-Sr.) (25) walks off the field after beating UNI 29-26 in triple overtime of their season opening game at Jack Trice Stadium on Saturday, Aug. 31, 2019 in Ames. Brian Powers/The Register

Iowa State linebacker Marcel Spears Jr. (R-Sr.) (42) mimics a play as the team walks off the field after beating UNI 29-26 in triple overtime of their season opening game at Jack Trice Stadium on Saturday, Aug. 31, 2019 in Ames. Brian Powers/The Register

Iowa State wide receiver La'Michael Pettway (R-Sr.) (7) can't come up with a pass around the defense of UNI's Omar Brown (24) during their season opening game at Jack Trice Stadium on Saturday, Aug. 31, 2019 in Ames. Iowa State would go on to defeat UNI in triple overtime 29-26. Brian Powers/The Register

Fans react after Iowa State wide receiver La'Michael Pettway (R-Sr.) (7) scored a touchdown during their season opening game at Jack Trice Stadium on Saturday, Aug. 31, 2019 in Ames. Iowa State would go on to defeat UNI in triple overtime 29-26. Brian Powers/The Register

UNI's Deion McShane (4) is tackled by Iowa State defensive back Justin Bickham (R-Sr.) (7) during their season opening game at Jack Trice Stadium on Saturday, Aug. 31, 2019 in Ames. Iowa State would go on to defeat UNI in triple overtime 29-26. Brian Powers/The Register

UNI's Will McElvain (13) looks for a pass during their season opening game at Jack Trice Stadium on Saturday, Aug. 31, 2019 in Ames. Iowa State would go on to defeat UNI in triple overtime 29-26. Brian Powers/The Register

UNI reacts after UNI's Deion McShane (4) scored in overtime of their season opening game at Jack Trice Stadium on Saturday, Aug. 31, 2019 in Ames. Iowa State would go on to defeat UNI in triple overtime 29-26. Brian Powers/The Register

UNI's Jaylin James (83) catches a pass during their season opening game at Jack Trice Stadium on Saturday, Aug. 31, 2019 in Ames. Iowa State would go on to defeat UNI in triple overtime 29-26. Brian Powers/The Register

Iowa State running back Sheldon Croney Jr. (R-Sr.) (25) catches a pass in overtime of their season opening game at Jack Trice Stadium on Saturday, Aug. 31, 2019 in Ames. Iowa State would go on to defeat UNI in triple overtime 29-26. Brian Powers/The Register

Iowa State running back Sheldon Croney Jr. (R-Sr.) (25) fumbles the ball in overtime of their season opening game at Jack Trice Stadium on Saturday, Aug. 31, 2019 in Ames. Iowa State would go on to defeat UNI in triple overtime 29-26. Brian Powers/The Register

Iowa State running back Sheldon Croney Jr. (R-Sr.) (25) in surrounded by teammates after scoring the game winning touchdown in overtime of their season opening game at Jack Trice Stadium on Saturday, Aug. 31, 2019 in Ames. Iowa State would go on to defeat UNI in triple overtime 29-26. Brian Powers/The Register

Iowa State quarterback Brock Purdy (So.) (15) falls in for a touchdown at the end of regulation that was called back for holding during their season opening game at Jack Trice Stadium on Saturday, Aug. 31, 2019 in Ames. Iowa State would go on to defeat UNI in triple overtime 29-26. Brian Powers/The Register

Iowa State quarterback Brock Purdy (So.) (15) celebrates after scoring a touchdown at the end of regulation that was called back for holding during their season opening game at Jack Trice Stadium on Saturday, Aug. 31, 2019 in Ames. Iowa State would go on to defeat UNI in triple overtime 29-26. Brian Powers/The Register

Iowa State quarterback Brock Purdy (So.) (15) celebrates after scoring a touchdown at the end of regulation that was called back for holding during their season opening game at Jack Trice Stadium on Saturday, Aug. 31, 2019 in Ames. Iowa State would go on to defeat UNI in triple overtime 29-26. Brian Powers/The Register

Iowa State running back Kene Nwangwu (R-Jr.) (3) rushes during their season opening game at Jack Trice Stadium on Saturday, Aug. 31, 2019 in Ames. Iowa State would go on to defeat UNI in triple overtime 29-26. Brian Powers/The Register

Iowa State wide receiver Deshaunte Jones (Sr.) (8) catches a pass during their season opening game at Jack Trice Stadium on Saturday, Aug. 31, 2019 in Ames. Iowa State would go on to defeat UNI in triple overtime 29-26. Brian Powers/The Register

Iowa State wide receiver La'Michael Pettway (R-Sr.) (7) runs in for a touchdown during their season opening game at Jack Trice Stadium on Saturday, Aug. 31, 2019 in Ames. Iowa State would go on to defeat UNI in triple overtime 29-26. Brian Powers/The Register

Iowa State fans hold up a flag after a touchdown during their season opening game at Jack Trice Stadium on Saturday, Aug. 31, 2019 in Ames. Iowa State would go on to defeat UNI in triple overtime 29-26. Brian Powers/The Register

UNI's Jaylin James (83) catches a pass during their season opening game at Jack Trice Stadium on Saturday, Aug. 31, 2019 in Ames. Iowa State would go on to defeat UNI in triple overtime 29-26. Brian Powers/The Register

Iowa State quarterback Brock Purdy (So.) (15) just has the ball knocked away by UNI's Elerson G. Smith (16) during their season opening game at Jack Trice Stadium on Saturday, Aug. 31, 2019 in Ames. Iowa State would go on to defeat UNI in triple overtime 29-26. Brian Powers/The Register

Iowa State fans argue a call during their season opening game at Jack Trice Stadium on Saturday, Aug. 31, 2019 in Ames. Iowa State would go on to defeat UNI in triple overtime 29-26. Brian Powers/The Register

Iowa State wide receiver Deshaunte Jones (Sr.) (8) rushes during their season opening game at Jack Trice Stadium on Saturday, Aug. 31, 2019 in Ames. Iowa State would go on to defeat UNI in triple overtime 29-26. Brian Powers/The Register

Iowa State wide receiver Deshaunte Jones (Sr.) (8) rushes during their season opening game at Jack Trice Stadium on Saturday, Aug. 31, 2019 in Ames. Iowa State would go on to defeat UNI in triple overtime 29-26. Brian Powers/The Register

Iowa State fans celebrate a first down during their season opening game at Jack Trice Stadium on Saturday, Aug. 31, 2019 in Ames. Iowa State would go on to defeat UNI in triple overtime 29-26. Brian Powers/The Register

Iowa State wide receiver Tarique Milton (R-So.) (1) tries to break a tackle during their season opening game at Jack Trice Stadium on Saturday, Aug. 31, 2019 in Ames. Iowa State would go on to defeat UNI in triple overtime 29-26. Brian Powers/The Register

Iowa State wide receiver Tarique Milton (R-So.) (1) tries to break the tackle of UNI's Omar Brown (24) during their season opening game at Jack Trice Stadium on Saturday, Aug. 31, 2019 in Ames. Iowa State would go on to defeat UNI in triple overtime 29-26. Brian Powers/The Register

UNI's Xavior Williams (9) is tackled by Iowa State linebacker Chandler Pulvermacher (R-Fr.) (36) during their season opening game at Jack Trice Stadium on Saturday, Aug. 31, 2019 in Ames. Iowa State would go on to defeat UNI in triple overtime 29-26. Brian Powers/The Register

Basketball recruit Xavier Foster sits in the stands and watches ISU play UNI during their season opening game at Jack Trice Stadium on Saturday, Aug. 31, 2019 in Ames. Iowa State would go on to defeat UNI in triple overtime 29-26. Brian Powers/The Register

Iowa State running back Sheldon Croney Jr. (R-Sr.) (25) rushes during their season opening game at Jack Trice Stadium on Saturday, Aug. 31, 2019 in Ames. Iowa State would go on to defeat UNI in triple overtime 29-26. Brian Powers/The Register

Iowa State wide receiver Deshaunte Jones (Sr.) (8) can't come up with a pass during their season opening game at Jack Trice Stadium on Saturday, Aug. 31, 2019 in Ames. Iowa State would go on to defeat UNI in triple overtime 29-26. Brian Powers/The Register

Iowa State head coach Matt Campbell runs out of the tunnel followed by the team before their season opening game at Jack Trice Stadium on Saturday, Aug. 31, 2019 in Ames. Iowa State takes a 3-0 lead over UNI into halftime. Brian Powers/The Register

Iowa State players touch the Honor before Victory plaque before their season opening game at Jack Trice Stadium on Saturday, Aug. 31, 2019 in Ames. Iowa State takes a 3-0 lead over UNI into halftime. Brian Powers/The Register

Iowa State defensive end Cordarrius Bailey (R-So.) (18) walks through the smoke before their season opening game at Jack Trice Stadium on Saturday, Aug. 31, 2019 in Ames. Iowa State takes a 3-0 lead over UNI into halftime. Brian Powers/The Register

Basketball recruit Xavier Foster watches ISU take on UNI during their season opening game at Jack Trice Stadium on Saturday, Aug. 31, 2019 in Ames. Iowa State takes a 3-0 lead over UNI into halftime. Brian Powers/The Register

Iowa State head coach Matt Campbell runs of the field during their season opening game at Jack Trice Stadium on Saturday, Aug. 31, 2019 in Ames. Iowa State takes a 3-0 lead over UNI into halftime. Brian Powers/The Register

The Iowa State Marching band performs during their season opening game at Jack Trice Stadium on Saturday, Aug. 31, 2019 in Ames. Iowa State takes a 3-0 lead over UNI into halftime. Brian Powers/The Register

The Iowa State Marching band performs during their season opening game at Jack Trice Stadium on Saturday, Aug. 31, 2019 in Ames. Iowa State takes a 3-0 lead over UNI into halftime. Brian Powers/The Register

UNI's Trevor Allen (25) is tackled by Iowa State defensive lineman Ray Lima (R-Sr.) (58) during their season opening game at Jack Trice Stadium on Saturday, Aug. 31, 2019 in Ames. Iowa State takes a 3-0 lead over UNI into halftime. Brian Powers/The Register

Iowa State wide receiver Tarique Milton (R-So.) (1) rushes during their season opening game at Jack Trice Stadium on Saturday, Aug. 31, 2019 in Ames. Iowa State takes a 3-0 lead over UNI into halftime. Brian Powers/The Register

UNI's Will McElvain (13) calls out a play during their season opening game at Jack Trice Stadium on Saturday, Aug. 31, 2019 in Ames. Iowa State takes a 3-0 lead over UNI into halftime. Brian Powers/The Register

Iowa State tight end Chase Allen (R-Jr.) (11) can't come up with a pass during their season opening game at Jack Trice Stadium on Saturday, Aug. 31, 2019 in Ames. Iowa State takes a 3-0 lead over UNI into halftime. Brian Powers/The Register

Iowa State running back Breece Hall (Fr.) (28) rushes during their season opening game at Jack Trice Stadium on Saturday, Aug. 31, 2019 in Ames. Iowa State would go on to defeat UNI in triple overtime 29-26. Brian Powers/The Register

Iowa State quarterback Brock Purdy (So.) (15) hands off to Iowa State running back Sheldon Croney Jr. (R-Sr.) (25) as he runs in for the game winning touchdown in triple overtime during their season opening game at Jack Trice Stadium on Saturday, Aug. 31, 2019 in Ames. Iowa State would go on to defeat UNI 29-26. Brian Powers/The Register

Iowa State running back Sheldon Croney Jr. (R-Sr.) (25) runs in for the game winning touchdown in triple overtime during their season opening game at Jack Trice Stadium on Saturday, Aug. 31, 2019 in Ames. Iowa State would go on to defeat UNI 29-26. Brian Powers/The Register

Iowa State celebrates with Iowa State running back Sheldon Croney Jr. (R-Sr.) (25) after he scored the game winning touchdown in triple overtime during their season opening game at Jack Trice Stadium on Saturday, Aug. 31, 2019 in Ames. Iowa State would go on to defeat UNI 29-26. Brian Powers/The Register

Iowa State fans celebrate after Iowa State running back Sheldon Croney Jr. (R-Sr.) (25) scored the game winning touchdown in triple overtime during their season opening game at Jack Trice Stadium on Saturday, Aug. 31, 2019 in Ames. Iowa State would go on to defeat UNI 29-26. Brian Powers/The Register

Iowa State quarterback Brock Purdy (So.) (15) enters the field before their season opening game at Jack Trice Stadium on Saturday, Aug. 31, 2019 in Ames. Iowa State takes a 3-0 lead over UNI into halftime. Brian Powers/The Register

Iowa State wide receiver Deshaunte Jones (Sr.) (8) avoids the tackle of UNI's Omar Brown (24) during their season opening game at Jack Trice Stadium on Saturday, Aug. 31, 2019 in Ames. Iowa State takes a 3-0 lead over UNI into halftime. Brian Powers/The Register

Iowa State head coach Matt Campbell argues a call during their season opening game at Jack Trice Stadium on Saturday, Aug. 31, 2019 in Ames. Iowa State takes a 3-0 lead over UNI into halftime. Brian Powers/The Register

UNI's Isaiah Weston (80) waits for a pass during their season opening game at Jack Trice Stadium on Saturday, Aug. 31, 2019 in Ames. Iowa State takes a 3-0 lead over UNI into halftime. Brian Powers/The Register

Iowa State quarterback Brock Purdy (So.) (15) looks for a pass during their season opening game at Jack Trice Stadium on Saturday, Aug. 31, 2019 in Ames. Iowa State takes a 3-0 lead over UNI into halftime. Brian Powers/The Register

Iowa State place kicker Connor Assalley (R-Jr.) (96) gets congratulations after hitting a field goal during their season opening game at Jack Trice Stadium on Saturday, Aug. 31, 2019 in Ames. Iowa State takes a 3-0 lead over UNI into halftime. Brian Powers/The Register

UNI's Will McElvain (13) is tackled by the ISU defense during their season opening game at Jack Trice Stadium on Saturday, Aug. 31, 2019 in Ames. Iowa State takes a 3-0 lead over UNI into halftime. Brian Powers/The Register

Iowa State running back Breece Hall (Fr.) (28) rushes during their season opening game at Jack Trice Stadium on Saturday, Aug. 31, 2019 in Ames. Iowa State takes a 3-0 lead over UNI into halftime. Brian Powers/The Register

Iowa State tight end Chase Allen (R-Jr.) (11) can't come up with a pass around the defense of UNI's Xavior Williams (9) during their season opening game at Jack Trice Stadium on Saturday, Aug. 31, 2019 in Ames. Iowa State takes a 3-0 lead over UNI into halftime. Brian Powers/The Register

Iowa State linebacker O'Rien Vance (R-So.) (34) dives to tackle UNI's Will McElvain (13) during their season opening game at Jack Trice Stadium on Saturday, Aug. 31, 2019 in Ames. Iowa State takes a 3-0 lead over UNI into halftime. Brian Powers/The Register

UNI's Matthew Cook (97) kicks a field goal during their season opening game at Jack Trice Stadium on Saturday, Aug. 31, 2019 in Ames. Iowa State would go on to defeat UNI in triple overtime 29-26. Brian Powers/The Register

UNI's Matthew Cook (97) reacts after kicking an extra point in overtime during their season opening game at Jack Trice Stadium on Saturday, Aug. 31, 2019 in Ames. Iowa State would go on to defeat UNI in triple overtime 29-26. Brian Powers/The Register

UNI's Matthew Cook (97) kicks an extra point in overtime during their season opening game at Jack Trice Stadium on Saturday, Aug. 31, 2019 in Ames. Iowa State would go on to defeat UNI in triple overtime 29-26. Brian Powers/The Register