Histopathological classification of Oligodendroglial
tumours has a subjective component. Oligodendrogliomas are one of the most
chemosensitive solid tumours and that loss of chromosome (LOH) 1p was tightly
associated with chemotherapy response. The correlation between in vivo and ex
vivo NMR metabolic profiles and gene expression has provided some molecular
biomarkers for supporting the classification of Oligodendroglial in an
objective manner. Statistical significant correlations has been found between
worst prognosis and lower survival with increasing amounts of some Cholines
compounds, fatty acids and alanine for ex vivo HR-MAS spectra. Likewise, a
correlation between mI/Cr and LOH/ROH 1p/19 loss has been found.