Metabolic Medication ByProducts

By-products of medication metabolism have been used to measure adherence (Rumbo et al. 2002). One significant benefit of this method is that metabolites accumulate over time, and hence their level reflects the level of medication intake over time rather than recent use. This method may be less sensitive than others in that only a significant deviation from the prescribed regimen will be detected. Furthermore, drug metabolism may be affected by factors other than intake (e.g., level of activity of an enzyme that is responsible for the metabolite that is being measured) and may therefore differ across patients. This method is applicable to only a minority of cases in which metabolic by-products of a medication can be detected.

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