Laboratory of Stem Cell Oncology

Yasuhiro Yamada, MD, PhD

Epigenetic regulation plays a critical role for both the stable maintenance of cellular identity and the reprogramming process. Accumulating evidence suggests that epigenetic abnormalities represented by abnormal DNA methylation have been involved in cancer development. Taking advantage of reprogramming technology to actively alter epigenetic regulation, we are investigating the role of epigenetic regulation on cancer development, maintenance, and progression. Finally, we will try to develop a novel approach targeting epigenetic regulation to treat cancer patients.

Research and Education

Although cancer is generally believed to develop through accumulation of multiple genetic mutations, there is increasing evidence that cancer cells also acquire epigenetic abnormalities during development, maintenance, and progression. Because the epigenetic status of somatic cells changes dynamically through reprogramming, iPS cell technology can be utilized to actively and globally alter the epigenetic status of differentiated cells. Using this technology, we recently have proposed that some types of cancer can develop mainly through disruption of the epigenetic status triggered by dedifferentiation. We are also trying to reprogram cancer cells to uncover the role of epigenetic regulation in cancer cells. The data obtained would be applicable for devising novel strategies for both prevention and treatment of cancer.