Our recently acquired property has a pasture pond. Before us, it was used for cattle drinking water. We have no cattle, but have someone keeping the hay cut for us. The location of the pond does not allow a tractor to cut up to the edge of the pond because of the incline. It's really beginning to grow up badly. We use Remedy and Grazone with a 25 gallon sprayer and long hose, on a small trailer which we pull with a 4-wheeler, along roadsides, etc. Now, to my question. If we spray around the pond, will this in any way harm any fish in the pond or the wildlife that use the pond for drinking. We know that deer and other wildlife slip up to the pond to drink at night.

I would never use that sort of thing on anything, and, yes, I would say that it will cause all sorts of harm. Of course, this is a long debate and you will find many people here who would say I worry too much.

When I think of getting rid of brush, the first thing I think of is goats.

You don't want to use most herbicides around the pond, however you can use a hand sprayer and a herbicide that works on the bark. Its still a lot of work spraying each bush but it beats clearing by hand. I used Garlon 4, its expensive but it works and you can apply it in late winter when it easier to get to the brush.

Advantages
Effective year-round for selective control of trees and brush.
Can be applied at any time of year, including the winter
months, except when snow or water prevent spraying at the
desired height above ground level.
Year-round usage allows efficiency in crew allocation and
supervision.
Can be used where foliar applications arent convenient, such
as on steep or uneven terrain.
Applications are targeted, greatly reducing the potential for
injury to off-target vegetation.
Minimized impact on environmentally sensitive or erosion
prone areas.
How basal bark treatments work
Young bark is lipophilic, meaning its structure acts like an open
lattice, and allows fatty substances to move readily within it.
That is why Release or Garlon 4 mixed with an oil carrier is
able to move within and through young bark tissue. Basal bark
treatments work best on young tender bark.
This inward movement reaches and penetrates the cambium
(conductive tissue) and results in the herbicide creating a
chemical girdle of the stem. Complete control depends on the
stem being entirely encircled  termed wrap. Once the
chemical girdle is formed, it acts like a physical girdle to prevent
downward movement of nutrients to the roots, thus eventually
killing the treated plant.

Cutting down all of the stuff around the pond may not be good for the fish either. Bugs live on the weeds and they get blown into the water therefore feeding the fish. I consider the tall weeds around a pond to be apart of that ponds chain of life. At least don't cut them all down.