LOS ANGELES--(BUSINESS WIRE)--Apr 17, 2007 - ProNAi Therapeutics,
Inc., a biopharmaceutical company pioneering a new class of
nucleic-acid drugs based on DNA interference (DNAi), today
announced that its lead oncology therapeutic candidate, PNT2258,
has successfully demonstrated preclinical in vivo efficacy in
xenograft mice for a number of human cancers - including curative
events for difficult-to-treat Burkitt's Lymphoma.

Dr. Richard D. Gill, President and CEO of ProNAi, said, "Team
ProNAi is quite pleased with our early preclinical results for
PNT2258. Particularly encouraging is the fact that PNT2258 has
shown promising single agent efficacy and combination therapy
efficacy and drug-dose response for multiple cancer types including
both hematological and solid tumors."

He added, "However, a very exciting development was our
discovery that PNT2258, in combination with Rituximab, demonstrated
curative events in treating Daudi xenografts of human Burkitt's
Lymphoma in mice. The antitumor effect was rapid and durable. We
had 70% complete remissions in two groups of animals dosed with
PNT2258 and Rituximab."

In developing its DNAi(R)-based therapy, ProNAi reports that its
successful establishment of in vivo efficacy for formulated PNT2258
included:

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