Hydroxychloroquine induced cardiomyopathy and heart failure in twins

It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as lupus, rheumatoid arthritis, and others. Malaria is spread by mosquitoes, which transmit the parasites that cause the infection, usually in tropical and subtropical parts of the world.

INTRODUCTION Hydroxychloroquine-inducedcardiomyopathy is a rare and life-threatening condition characterized by restrictive hemodynamics. Drug cessation and aggressive afterload reduction halts disease allowing for clinical recovery. We present a 50-year-old woman with hydroxychloroquine-induced restrictive cardiomyopathyand correlate clinical, echocardiographic, and right heart. Hydroxychloroquine HCQ is a commonly used drug that has been linked to drug-inducedcardiomyopathy. A 57 year old female with a history of systemic lupus erythematosus stable on HCQ for 30 years and known MYBPC3 gene positive hypertrophic cardiomyopathy HCM presented with decompensated heart Is a platform for academics to share research papers.

For example, it may be combined with an antibiotic to treat chronic Q-fever, which humans usually catch from farm animals or raw milk. Plaquenil is used to treat other types of infections too.

Hydroxychloroquine induced cardiomyopathy and heart failure in twins

HeartFailure/Cardiomyopathy Boston Medical Center, HYDROXYCHLOROQUINECARDIOMYOPATHY IN A PATIENT WITH GENE.

We present a case of twin sisters who both suffered from systemic lupus erythematosus SLE and HCQ-inducedcardiomyopathy presenting with decompensated heartfailure HF, suggesting that genetic predisposition might be a factor in HCQ-inducedcardiomyopathy. Clinical manifestations of antimalarial-induced cardiotoxicity can manifest as restrictive cardiomyopathy, dilated cardiomyopathy, or conduction abnormalities such as bundle branch and atrioventricular block. Patients usually present with HF symptoms. However, non-specific chest discomfort may be a presenting or coexisting feature. Systemic lupus erythematosus SLE is a chronic autoimmune disorder that manifests with multiorgan inflammation. Cardiac involvement is common, with manifestation that include pericarditis, myocarditis, conduction defects, valvular disease, and coronary artery disease. In addition to cardiac disease in adults with SLE, the children of women with SLE can develop neonatal lupus by passive.

Chloroquine has long been used in the treatment or prevention of malaria from Plasmodium vivax, P. malariae, excluding the malaria parasite Plasmodium falciparum, for it started to develop widespread resistance to it. Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance.