COUGH and Doxycycline

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COUGH Symptoms and Causes

Coughing is a reflex that keeps your throat and airways clear. Although it can be annoying, Coughing helps your body heal or protect itself. Coughs can be either acute or chronic. Acute Coughs begin suddenly and usually last no more than 2 to 3 weeks. Acute Coughs are the kind you most often get with a cold, flu, or acute bronchitis. Chronic Coughs last longer than 2 to 3 weeks. Causes of chronic Cough include

Chronic bronchitis

Asthma

Allergies

COPD (chronic obstructive pulmonary disease)

GERD (gastroesophageal reflux disease)

Smoking

Throat disorders, such as croup in young children

Some medicines

Water can help ease your Cough - whether you drink it or add it to the air with a steamy shower or vaporizer. If you have a cold or the flu, antihistamines may work better than non-prescription Cough medicines. Children under four should not have Cough medicine. For children over four, use caution and read labels carefully.

COUGH Clinical Trials and Studies

Treatments might be new drugs or new combinations of drugs, new surgical procedures or devices, or new ways to use existing treatments. The goal of clinical trials is to determine if a new test or treatment works and is safe. Clinical trials can also look at other aspects of care, such as improving the quality of life for people with chronic illnesses. People participate in clinical trials for a variety of reasons. Healthy volunteers say they participate to help others and to contribute to moving science forward. Participants with an illness or disease also participate to help others, but also to possibly receive the newest treatment and to have the additional care and attention from the clinical trial staff.

Improvement of nasal congestion and Cough; Improvement of non-obstructive nasal symptoms; Reduction of the frequency of nighttime awakenings of parent/guardian/roommate of the child; Reduction of vomiting frequency episodes triggered by Coughing; Improvement of acute rhinitis signs; Use of rescue medication; Overall impression of improvement by the investigator; Safety descriptive about occurence of adverse events, evaluation of results of general physical examination.

Total Cough counts in Part A.; Number of Coughs following each dose of capsaicin, following a single dose of GSK2339345 or placebo; Number of Coughs following each dose of citric acid, following a single dose of GSK2339345 or placebo; Cough counts following GSK2339345 or placebo at Visits 1, 2 and 3 over shorter epochs (e.g. 1 hour or 15 minute intervals); Urge to Cough visual analogue scale (VAS) 1 hour post-last dose at Visits 1, 2 and 3; Cough severity VAS 1 hour post-last dose at Visits 1, 2 and 3; To assess the safety profile of GSK2339345 versus placebo; The systemic pharmacokinetics (PK) profile of GSK2339345.

If you think you may have a medical emergency, call your doctor or 911 immediately.

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