S100A1Related Pathways

S100A1Related Product

S100A1Background

Gene Summary: The protein encoded by S100A1 gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-induced Ca2+ release, inhibition of microtubule assembly, and inhibition of protein kinase C-mediated phosphorylation. Reduced expression of this protein has been implicated in cardiomyopathies. [provided by RefSeq, Jul 2008]

General information above from NCBI

Subunit structure: Dimer of either two alpha chains, or two beta chains, or one alpha and one beta chain. Also forms heterodimers with S100P. Interacts with AGER and CAPZA1 (By similarity). Interacts with FKBP4. Interacts with RYR1 and RYR2. Interacts with CACYBP in a calcium-dependent manner.

Subcellular location: Cytoplasm.

Tissue specificity: Highly prevalent in heart. Also found in lesser quantities in skeletal muscle and brain.

S100A1 is a Ca2+binding protein of the EF-hand type that belongs to the S100 protein family. S100 proteins consisting of at least 19 members exist as dimers in the cytoplasm and/or nucleus of a wide range of cells, and are involved in the regulation of a number of cellular processes such as cell-cycle progression and cell differentiation.This protein has been shown to function in the processes including stimulation of Ca2+-induced Ca2+ release, inhibition of microtubule assembly, and inhibition of PKC-mediated phosphorylation.. Phosphoglucomutase is a target protein whose activity is antagonistically regulated by S100A1, and recently, S100A1 is also identified as a potent molecular chaperone and a new member of the Hsp70/Hsp90 multichaperone complex. S100A1 displays a tissue-specific expression pattern with highest levels in myocardium and is considered to be an important regulator of cardiac contractility. Accordingly, reduced expression or mutations of S100A1 gene have been implicated in cardiomyopathies.

S100A1Alternative Name

S100,S100A,S100A1,S100-alpha, [human]

AI266795,S100,S100a,S100a1, [mouse]

S100A1Related Studies

Remppis, A .et al., 1996, Biochim. Biophs. Acta. 1313: 253-257.

Most, P. et al., 2001, Proc. Natl. Acad. Sci. U.S.A. 98: 13889-13894

Okada, M. et al., 2004, J. Biol. Chem. 279: 4221-4233.

Schafer, W.E. et al., 1995, Genomics. 25: 638-643.

Landar, A. et al., 1996, Cell. Calcium. 20: 279-285.

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