Despite 50 years of research, the etiology of Kawasaki disease (KD), the most common cause of acquired heart disease in children, remains a mystery. Fueled by epidemiologic and clinical clues that the disease was triggered by an infectious agent that elicited a dramatic immune response in genetically susceptible children, investigators vigorously searched for the responsible agent(1). Thus far, a long list of discarded pathogens is all that remains of these attempts to find the inflammation-causing agent. Application of reverse genetics to engineer synthetic antibodies to track down a putative new virus has shown some promise, but the agent still remains elusive(2). (SELECT FULL TEXT TO CONTINUE).