Drug delivery

Drug delivery refers to approaches, formulations, technologies, and systems for transporting a pharmaceutical compound in the body as needed to safely achieve its desired therapeutic effect. It may involve scientific site-targeting within the body, or it might involve facilitating systemic pharmacokinetics; in any case, it is typically concerned with both quantity and duration of drug presence. Drug delivery is often approached via a drug's chemical formulation, but it may also involve medical devices or drug-device combination products. Drug delivery is a concept heavily integrated with dosage form and route of administration, the latter sometimes even being considered part of the definition.

Drug delivery technologies modify drug release profile, absorption, distribution and elimination for the benefit of improving product efficacy and safety, as well as patient convenience and compliance. Drug release is from: diffusion, degradation, swelling, and affinity-based mechanisms. Most common routes of administration include the preferred non-invasive peroral (through the mouth), topical (skin), transmucosal (nasal, buccal/sublingual, vaginal, ocular and rectal) and inhalation routes. Many medications such as peptide and protein, antibody, vaccine and gene based drugs, in general may not be delivered using these routes because they might be susceptible to enzymatic degradation or can not be absorbed into the systemic circulation efficiently due to molecular size and charge issues to be therapeutically effective. For this reason many protein and peptide drugs have to be delivered by injection or a nanoneedle array.
For example, many immunizations are based on the delivery of protein drugs and are often done by injection.

Editors

Vladimir Torchilin was appointed co-editor in 2009 and is currently Distinguished Professor of Pharmaceutical Sciences at The Bouvé College of Health Sciences, Northeastern University, Boston, MA, USA.

Publication Format

Drug Delivery publishes 8 issues per year in simultaneous print and online editions and is available on a subscription basis. Individual articles can be purchased on a pay-per-view basis. The full text of all articles is offered in PDF and PDF Plus formats. All back-issues of the journal are available online and are hosted on the publisher's website.

Drug delivery

Drug delivery refers to approaches, formulations, technologies, and systems for transporting a pharmaceutical compound in the body as needed to safely achieve its desired therapeutic effect. It may involve scientific site-targeting within the body, or it might involve facilitating systemic pharmacokinetics; in any case, it is typically concerned with both quantity and duration of drug presence. Drug delivery is often approached via a drug's chemical formulation, but it may also involve medical devices or drug-device combination products. Drug delivery is a concept heavily integrated with dosage form and route of administration, the latter sometimes even being considered part of the definition.

Drug delivery technologies modify drug release profile, absorption, distribution and elimination for the benefit of improving product efficacy and safety, as well as patient convenience and compliance. Drug release is from: diffusion, degradation, swelling, and affinity-based mechanisms. Most common routes of administration include the preferred non-invasive peroral (through the mouth), topical (skin), transmucosal (nasal, buccal/sublingual, vaginal, ocular and rectal) and inhalation routes. Many medications such as peptide and protein, antibody, vaccine and gene based drugs, in general may not be delivered using these routes because they might be susceptible to enzymatic degradation or can not be absorbed into the systemic circulation efficiently due to molecular size and charge issues to be therapeutically effective. For this reason many protein and peptide drugs have to be delivered by injection or a nanoneedle array.
For example, many immunizations are based on the delivery of protein drugs and are often done by injection.

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To overcome this barrier, the focus has been shifted to the novel drugdelivery systems that enquire a minimum dose and provide maximum benefit. Also, apart from this trend of novel drugdelivery, companies are also developing novel drugs... for traditional delivery of the drug....

As part of this project Machavert plans to combine these novel small molecules with its own drugdelivery platform technology, MP1000 ... Additionally, the RAL inhibitors can be combined with Machavert's phospholipid drugdelivery platform that shows KRAS specific anti-tumor activity ......

DURECT is a biopharmaceutical company actively developing therapeutics based on its Epigenetic Regulator Program and proprietary drugdelivery platforms ... In addition, for the assignment of certain patent rights related to its drugdelivery technology, DURECT will receive single digit sales-based earn-out payments from U.S....

19, 2018 /PRNewswire/ -- Patients with certain rare, chronic and complex conditions can now obtain the medications that may improve or save their lives from AllianceRx Walgreens Prime, a leading central specialty and homedelivery pharmacy ... The drugs now available for AllianceRx Walgreens Prime patients include.....

With its simple, wearable design, the disposable Pod provides up to three days of non-stop insulin delivery, without the need to see or handle a needle.Insuletalso leverages the unique design of its Pod, by tailoring its Omnipod technology platform for the delivery of non-insulin subcutaneous drugs across other therapeutic areas....

GILLETTE, Wyo. (AP) - A 23-year-old woman has pleaded guilty to taking meth into a Wyoming jail where she gave it to others in custody. The GilletteNews Record reports that Hallie M. Stratton pleaded guilty to taking drugs into jail and to delivery of meth in a plea agreement ... ....

A 28-year-old Harrison Township man accused of committing two road-rage incidents last winter pleaded no contest in hopes of gaining probation ... The woman drove on several streets in the area to get away from Books ... He also was charged in 2013 with delivery of non-narcotic drugs and possession of an analogue and pleaded guilty to the delivery charge....

The army has drawn up a secret plan to put troops on the street to maintain order in case no-deal Brexit unleashes chaos on the streets. Soldiers could be called on to guard medicine deliveries as hospitals stockpiled drugs, a report has suggested ... But still, blue passports (Getty) ... ....