BradyArticle has been the leader for years in defining the biochemical genetics of the sphingolipidoses. In this neurological review, he turns his attention to therapy that he has pioneered and brings us up to date.

SmithArticle presents salient basic science mechanisms of adenovirus vectors for gene therapy of serious neurologic diseases. It is a timely review for the clinician gauging the future prospects of this inevitable form of neurologic therapy in the 21st century.