I've noticed a number of people on the Tech forums have various different issues, which could be fixed by following these next steps:

Disable all mods from within NS2 first, and unsubscribe from any in your Mods list. (You must go through steam to properly unsubscribe!)

Then.....

Delete NS2 from Steam. Then do a manual NS2 Cleanup (this is not done when Steam deletes NS2 from your Library) like follows:

1) Delete NS2 from Steam the normal way.2) Go to your hidden folder where settings are saved C:\Users\YOURUSERNAMEHERE\AppData\Roaming and Delete the 'Natural Selection 2' folder.3) Go to your SteamApps\common Directory and make sure you delete 'natural selection 2'4) Restart your PC (to be on the safe side)5) Reinstall NS2 fresh from a new download.

Try those steps. Chances are, your NS2 is now working fine! :D

If that does not help then post a thread with your issue, with as much evidence as possible (screenshots/video) and also run techsupport.exe in your NS2 Steam Directory. Then upload it somewhere for us to see & report back.

Thanks all!

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Also try to start the game in window mode, click on options and select your desired resolution and start normal again. There was once a bug there your mouse icon was not correctly displayed. This fixed it for me.Greetings,Warforce17

I had this a couple of times as wel...everytime, I "fixed" it, by alt-tabbing out of the game, and then R-click on the NS2 icon in the windows-taskbar, and select Close.A restart fixed it, untill the next same random-like issue.