Specifications: NCC antibody

Full Name

solute carrier family 12 (sodium/chloride transporters), member 3

Product Description

Rabbit polyclonal antibody to NCC

Background

NCC, a thiazide-sensitive NaCl co-transporter, is found on the apical membrane of the distal convoluted tubule, where it is the principal mediator of Na+ and Cl- reabsorption in this segment of the nephron. It is activated by phosphorylation, and has been implicated in renal NaCl and K+ homeostasis. Regulation of NCC expression and phosphorylation by dietary NACl restriction appears to involve SGK1. In experiments with angiotensin II-infused mice, increased sensitivity to Ang II may involved over-activity of NCC. Therefore, NCC is the target of thiazide diuretics used in the treatment of hypertension. Molecular experiments have also shown that NCC has been detected in the lens cortex, core and fiber cells of a rat.

Synonyms

NCC, TSC

Host

Rabbit

Clonality

Polyclonal

Target

NCC

Isotype

IgG

Immunogen

AA74-95 (rat), 76-97 (hum)

Antigen Species

Rat

Species Reactivity

Human, Mouse, Rat

Storage Conditions: NCC antibody

Storage Buffer

in 50% glycerol, 0.1% BSA, 1mM sodium azide

Storage Instruction

Aliquot and store at -20 C. Avoid repeated freeze-thaw cycles.

Notes

For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.