Indications for Mefloquine Tablets:

Adult:

Take with food and 8oz water. Prophylaxis: 250mg once weekly starting 1 week before departure, continuing during travel to endemic areas and for 4 weeks after return. Treatment: 1250mg as a single dose.

Children:

Give with food and water. May crush tab and mix in water. Prophylaxis: 3–5mg/kg once weekly starting 1 week before departure, continuing during travel to endemic areas and for 4 weeks after return. Treatment: ≤6months of age: contact manufacturer. ≥6months: 20–25mg/kg as single dose or as 2 doses 6–8 hours apart.

Contraindications:

Quinine, quinidine, or related allergy. Not for prophylactic use in patients with psychiatric disorders or history of depression or seizures.

Interactions:

Do not use during or within 12 hours of quinine, quinidine, chloroquine (may cause seizures or ECG changes); caution with drugs that cause QTc prolongation (eg, β-blockers). Do not use halofantrine or ketoconazole during or within 15 weeks of last mefloquine dose. Caution with rifampin. May affect or be affected by CYP3A4 inhibitors or inducers, p-glycoprotein substrates. May antagonize antiepileptics. Complete live oral bacterial vaccinations (eg, typhoid) at least 3 days before 1st mefloquine dose. Monitor anticoagulants, antidiabetics, antiepileptics 2–3 weeks before departure.