Profile

Francisco Lázaro-Diéguez (Barakaldo, Spain, 1977)

I started my research in the laboratory of Jaime Renau-Piqueras (Hospital La Fe, Valencia, Spain) working in the field of the fetal alcohol syndrome. As a graduate student in the Gustavo Egea Lab (University of Barcelona, Spain) I focused my studies in 1) the implication of the actin filaments in the maintenance of the Golgi apparatus ultrastructure, ionic homeostasis and post-Golgi traffic and 2) the development of a cellular model to address the mechanisms of protein degradation of an actin aggresome/Hirano-like body.

During my postdoctoral period in the Anne Müsch Lab (Albert Einstein College of Medicine, Bronx, NY) I explored the role of the kinase Par1b and the implication of cell-cell adhesion during cell division for the establishment of hepatocytic vs. columnar polarity in epithelial cells. I also studied the cell shape impacts on the positioning of the mitotic spindle.

The goal of my current research is to elucidate the mechanisms of post-Golgi traffic for apical and basolateral cargoes in hepatocyte-derived cells.