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*End of Brotherhood
Ed: There's no such thing as a painless lesson. They just don't exist. Sacrifices are necessary. You can't gain anything without losing something first. Although, if you endure that pain, and walk away from it, you'll find that you now have a heart strong enough to overcome any obstacle. Yeah...a fullmetal heart.

I'm not sure what the exact words were so I copy and pasted from what a fan wrote.
The point is that life is not supposed to be easy; it's challenging that sometimes you want to give up. Life is like a school that never ends. If you want something so desperately, you have to work hard and never give up. Don't wait for it to happen; who knows when and if it'll happen - you have the power to change and take control. You'll get bruises and sacrifices may be made, but the end result is worth it. It’ll spread into your life and entire being, just don't limit yourself and give up. REMEMBER, impossible brings potential. Don't be like me who just uses it because it makes life easier to live x3 Obstacles are put in our way to see if what we want is worth fighting for. I'm not good at supporting myself, but I'm here for you if you need my support! I kinda digressed x3

Daddy may not have gotten the place he always wanted, but he had something better. He had love. –Eudora (Princess and the Frog)

The main quote is Princess and the Frog. I think this quote is important because some people die without doing all that they wanted or none at all. People want to do all they can so they can die without regrets. BUT I feel that even if you may not have gotten what you wanted, as long as you had love - that's all you need. Love is always better.
Which is why I used FMA. The Elrics wanted their mom back but never had it. Throughout their journey, they learned that what made them feel 'magical' - their source of power, alchemy- wasn't so important after all. The love they had gained was their power and they were fine with it.