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Exposure to carbon nanotubes induces significant changes in cellular biomechanics. Using nanoindentation, it is observed that the exposed cells have significantly higher stiffness when compared to controls, especially at the nuclear region, and significant increases in surface area. Carbon nanotubes (CNTs) are rolled-up cylindrical structures of single (single-walled carbon nanotube- SWCNT) or multiple (multi-walled carbon nanotube- MWCNT) sheets of graphene that have high aspect ratio, high electrical and thermal conductivity, ultra-light weight, and high mechanical strength. Their unique properties provide a tremendous potential for applications in fields as diverse as electronics , aerospace industries, sensors, actuators, or composites. Based on their properties, researchers have also been exploring CNTs potential for biological and biomedical applications as drug delivery systems, substrate for cells growth in tissue regeneration, therapeutic agents, or as vectors for gene transfection. Such broad applications of CNTs have led to an increased production level and thus increased concerns regarding human and environmental exposure. Further, given their applications in the biomedical field, understanding how biological systems interact with this nanomaterial is urgently needed to create safer therapies, and to regulate occupational exposures.