Diagnostic Utility

Caldesmon is a developmentally regulated protein involved in smooth muscle and non-muscle tissue contraction. The heavy-caldesmon is predominantly expressed in smooth muscle tissue and can be used as a smooth muscle marker. It is helpful in the distinction of smooth muscle neoplasm (positive) from myofibroblastic proliferation, such as nodular fasciitis (generally negative). It is also generally negative in endometrial stromal tumors.

Vendor

Dako

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