Because the IVC is not centrally located, there are some asymmetries in drainage patterns. The gonadal veins and suprarenal veins drain into the IVC on the right side, but into the renal vein on the left side, which in turn drains into the IVC. By contrast, all the lumbar veins and hepatic veins usually drain directly into the IVC.

Note that the vein that carries de-oxygenated blood from the upper half of the body is the superior vena cava.

In the embryo, the IVC and right atrium are separated by the Eustachian valve, also known in Latin as the valvula venae cavae inferiore (valve of the inferior vena cava). In the adult, this structure typically has totally regressed or remains as a small endocardial fold.[3]