Barfoot was born on June 15, 1919, in Edinburg, Mississippi. His grandmother was Choctaw, but Barfoot himself was not an official member of the Choctaw Nation; although he was eligible, his parents had never enrolled him.

After enlisting in the Army from Carthage, Mississippi, in 1940 and completing his training, Barfoot served with the 1st Infantry Division in Louisiana and Puerto Rico. In December 1941, he was promoted to sergeant and reassigned to the Headquarters Amphibious Force Atlantic Fleet in Quantico, Virginia, where he served until the unit was deactivated in 1943. He next joined the 157th Infantry Regiment, 45th Infantry Division, and was shipped to Europe.

During the Italian Campaign Barfoot participated in a series of amphibious landings: the Allied invasion of Sicily in July 1943, the invasion of mainland Italy at Salerno in September, and finally the landings at Anzio in late January 1944. His unit pushed inland from Anzio, and by May 1944 had reached the town of Carano, where he was to earn the MOH.

Barfoot was subsequently commissioned as a second lieutenant. His division moved into France and by September was serving in the Rhone valley. Barfoot learned he would be awarded the Medal of Honor and chose to have the presentation ceremony in the field, so that his soldiers could attend. He was formally presented with the medal on September 28, 1944, in Épinal, France, by Lieutenant General Alexander Patch.

Barfoot later served in the Korean War and the Vietnam War, and earned a Purple Heart. He reached the rank of colonel before retiring from the Army. In retirement, he lived in Amelia County, Virginia and later, Henrico County, Virginia, near his daughter. On October 9, 2009, the portion of Mississippi Highway 16 which runs from Carthage through his hometown of Edinburg to the border between Leake and Neshoba counties was named the "Van T. Barfoot Medal of Honor Highway".

MOH CITATION:

For conspicuous gallantry and intrepidity at the risk of life above and beyond the call of duty on 23 May 1944, near Carano, Italy. With his platoon heavily engaged during an assault against forces well entrenched on commanding ground, 2d Lt. Barfoot (then Tech. Sgt.) moved off alone upon the enemy left flank. He crawled to the proximity of 1 machinegun nest and made a direct hit on it with a hand grenade, killing 2 and wounding 3 Germans. He continued along the German defense line to another machinegun emplacement, and with his Thompson Submachine gun killed 2 and captured 3 soldiers. Members of another enemy machinegun crew then abandoned their position and gave themselves up to Sgt. Barfoot. Leaving the prisoners for his support squad to pick up, he proceeded to mop up positions in the immediate area, capturing more prisoners and bringing his total count to 17. Later that day, after he had reorganized his men and consolidated the newly captured ground, the enemy launched a fierce armored counterattack directly at his platoon positions. Securing a bazooka, Sgt. Barfoot took up an exposed position directly in front of 3 advancing Mark VI tanks. From a distance of 75 yards his first shot destroyed the track of the leading tank, effectively disabling it, while the other 2 changed direction toward the flank. As the crew of the disabled tank dismounted, Sgt. Barfoot killed 3 of them with his tommygun. He continued onward into enemy terrain and destroyed a recently abandoned German fieldpiece with a demolition charge placed in the breech. While returning to his platoon position, Sgt. Barfoot, though greatly fatigued by his Herculean efforts, assisted 2 of his seriously wounded men 1,700 yards to a position of safety.