Fusion

STRING allows inspection of the interaction evidence for any given network. Choose any of the viewers above (disabled if not applicable in your network).

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:query proteins and first shell of interactors

white nodes:second shell of interactors

Node Content

empty nodes:proteins of unknown 3D structure

filled nodes:some 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

lrp

Lrp (163 aa)

Predicted Functional Partners:

pntA

Alanine dehydrogenase (375 aa)

0.754

ftsK

DNA translocase FtsK (801 aa)

0.737

putA

Proline dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source (1055 aa)

0.680

crcB

Hypothetical protein; Important for reducing fluoride concentration in the cell, thus reducing its toxicity (129 aa)

0.677

IL0665

Recombination factor protein RarA (446 aa)

0.668

argF

Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline (316 aa)

0.659

lolA

Outer membrane lipoprotein-sorting protein; Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (200 aa)

0.632

gltB

Glutamate synthase subunit alpha (1488 aa)

0.625

rpoS

DNA-directed RNA polymerase sigma 38 subunit (322 aa)

0.615

serS

Seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (430 aa)

a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1

node2

node1 accession

node2 accession

node1 annotation

node2 annotation

score

IL0665

crcB

IL0665

IL0664

Recombination factor protein RarA

Hypothetical protein; Important for reducing fluoride concentration in the cell, thus reducing its toxicity

0.887

IL0665

ftsK

IL0665

IL0667

Recombination factor protein RarA

DNA translocase FtsK

0.904

IL0665

lolA

IL0665

IL0666

Recombination factor protein RarA

Outer membrane lipoprotein-sorting protein; Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)

0.896

IL0665

lrp

IL0665

IL0668

Recombination factor protein RarA

Lrp

0.668

IL0665

pntA

IL0665

IL0669

Recombination factor protein RarA

Alanine dehydrogenase

0.486

IL0665

serS

IL0665

IL0663

Recombination factor protein RarA

Seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

0.896

argF

gltB

IL0614

IL1075

Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline

Glutamate synthase subunit alpha

0.471

argF

lrp

IL0614

IL0668

Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline

Lrp

0.659

argF

rpoS

IL0614

IL0745

Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline

DNA-directed RNA polymerase sigma 38 subunit

0.623

crcB

IL0665

IL0664

IL0665

Hypothetical protein; Important for reducing fluoride concentration in the cell, thus reducing its toxicity

Recombination factor protein RarA

0.887

crcB

ftsK

IL0664

IL0667

Hypothetical protein; Important for reducing fluoride concentration in the cell, thus reducing its toxicity

DNA translocase FtsK

0.898

crcB

lolA

IL0664

IL0666

Hypothetical protein; Important for reducing fluoride concentration in the cell, thus reducing its toxicity

Outer membrane lipoprotein-sorting protein; Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)

0.887

crcB

lrp

IL0664

IL0668

Hypothetical protein; Important for reducing fluoride concentration in the cell, thus reducing its toxicity

Lrp

0.677

crcB

pntA

IL0664

IL0669

Hypothetical protein; Important for reducing fluoride concentration in the cell, thus reducing its toxicity

Alanine dehydrogenase

0.454

crcB

serS

IL0664

IL0663

Hypothetical protein; Important for reducing fluoride concentration in the cell, thus reducing its toxicity

Seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

0.885

ftsK

IL0665

IL0667

IL0665

DNA translocase FtsK

Recombination factor protein RarA

0.904

ftsK

crcB

IL0667

IL0664

DNA translocase FtsK

Hypothetical protein; Important for reducing fluoride concentration in the cell, thus reducing its toxicity

0.898

ftsK

lolA

IL0667

IL0666

DNA translocase FtsK

Outer membrane lipoprotein-sorting protein; Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)

0.902

ftsK

lrp

IL0667

IL0668

DNA translocase FtsK

Lrp

0.737

ftsK

pntA

IL0667

IL0669

DNA translocase FtsK

Alanine dehydrogenase

0.489

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Network Stats

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Functional enrichments in your networkNote: some enrichments may be expected here (why?)

Enrichment analysis is still ongoing, please wait ...

Statistical background

For the above enrichment analysis, the following statistical background is assumed: