In this work it could be demonstrated, that leukotriene-like substances released from pollen are able to induce physiological functions of neutrophil granulocytes, such as migration, calcium mobilization, upregulation of CD11b and also release of cytotoxic enzymes. These effects could be shown with polymorphonuclear granulocytes (PMN) from allergic as well as nonallergic individuals. Within the second part of this work, the effects of the antihistamine desloratadine on pollen-neutrophil interactions were examined. It was shown, that pre-incbation of PMN with desloratadine lead to inhibition of PMN`s effector functions induced by pollen extracts. «

In this work it could be demonstrated, that leukotriene-like substances released from pollen are able to induce physiological functions of neutrophil granulocytes, such as migration, calcium mobilization, upregulation of CD11b and also release of cytotoxic enzymes. These effects could be shown with polymorphonuclear granulocytes (PMN) from allergic as well as nonallergic individuals. Within the second part of this work, the effects of the antihistamine desloratadine on pollen-neutrophil interact... »