MGF &lpar;Mechano Growth &rpar; is a variant &comma; also available as synthetic&comma; water-based variant with less stability&period; MGF is generally derived from exercised or injured&sol;damaged muscle tissue&period; The biomolecule mimic IGF gene expression that augments stem cell population in the muscle tissue to promote hyperplasia&period; Addition of polyethylene glycol &lpar;PEG&rpar; with the compound prevents spontaneous degradation in the blood stream&comma; and increase plasma half-life&period;

PEG-MGF&comma; or PEGylated Mechano Growth is a new and innovative form of MGF that outperforms natural MGF many times over&period; MGF is a splice variant of the IGF gene which increases stem cell count in the muscle and allows for muscle fibers to fuse and mature&period; This is a process required for growth of adult muscle&period; Natural MGF is made locally and does not travel into the bloodstream&period; Synthetic MGF is water based and when administered intramuscularly&comma; travels into the bloodstream&period; MGF is only stable in the blood stream for only a few minutes&period;

PEGylation is the act of attaching a Polyethylene glycol &lpar;PEG&rpar; structure to another larger molecule &lpar;in this case&comma; MGF&rpar;&period; The PEG acts as a protective coating and the theory here is that this will allow the MGF to be carried through the blood stream without being broken down&period;

MGF exhibits local effects in skeletal muscle and without cannot travel through the body without modification&period; The problem with synthetic MGF is that it is introduced intramuscularly and is water based so it goes into the blood stream&period; When used this way&comma; MGF only remains stable in the blood stream for a few minutes&period; Biologically produced MGF is made locally and does not enter the bloodstream&period; It is also short acting so stability is not an issue&period; By PEGylating the MGF it is almost as efficient as local produced MGF when used intramuscularly&period; This is accomplished by surrounding part of the peptide with a structure of polyethylene glycol&comma; which can be attached to a protein molecule&period; The polyethylene glycol groups protect the peptide but don't surround it completely&period; The active sites of the peptide are still free to do their biological function&period; In this case the shell is a negative charged shield against positively charged compounds that would affect the protein&period; TNeurological research has shown that utilizing PEGylated MGF resulted in a longer more stable acting version of the MGF peptide in serum&sol;blood&period;

Why Mechano Growth &quest; Resistance training or more specifically&comma; a training that causes our muscles to work beyond their usual power leads to that familiar 'burning' sensation we all have had a chance to experience during an exercise&period; What happens to our muscles at that point is the following&colon; Every muscle is a cluster of muscle fibers &lpar;muscle cells&rpar;&comma; which at the point of extreme efforts tend to tear&period; The tearing of the muscle fibers is what causes the burning sensation&period; The torn parts form certain 'cavities' in the muscle tissue and those cavities represent a chance for a muscle to grow&period; After those 'cavities' are filled up with the muscle 'matter'&comma; we are left with a muscle of an increased mass&period; Why 'Mechano'&quest; Because tearing of the muscle fibers is an actual mechanical damage&comma; and the only way to achieve that kind of damage is through mechanical stimulation of the muscle tissue&period; Why Growth'&quest; Because Mechano Growth is responsible for accelerated muscle build-up processes&period; Besides accelerating muscle build-up processes Mechano Growth also helps create new muscle cells&period; That's a simplified way of looking at the whole process&period;

We will explain a few more details behind the workings of the Mechano Growth and PEG-MGF shortly&period;

Mechano Growth is a peptide hormone&comma; a natural physiological byproduct created in a human body as a result of an exercise&period; Mechano Growth &lpar;MGF&rpar; and are isoforms&period; Isoform is a protein with a slightly different form but usually a similar function as its 'fellow' isoform protein&period; Both&comma; MGF &lpar;which is a liver derived hormone&rpar; &lpar;which is produced in the muscles&rpar; have anabolic effects&comma; but the anabolic powers of the MGF are greater than those&period; Anabolic quality of a substance is such that increases the levels of synthesis&comma; either at a molecular or a cellular level&comma; meaning the Mechano Growth has a greater sensitivity to damages caused to muscles by exercise and induces the synthesis of a greater amount of proteins in skeletal muscles&period;

Another favorable effect of the Mechano Growth is its ability to activate the satellite cells of muscles &lpar;myosatellite cells&rpar;&period; Myosatellite cells behave as stem cells&period; Once they are activated they fuse&comma; form myoblastst&comma; proceed to differentiate and form entirely new muscle cells&period; Again&comma; the result is muscle growth&period;

But what about PEG-MGF&quest; Why do we at BeFit4Free produce the PEGylated version of the Mechano Growth if the MGF on its own has so much potential anyway&quest;

PEGylated protein &lpar;PEG-MGF&rpar; is the one that has Polyethylene Glycol added to it&period; The role of the Polyethylene Glycol molecule is to preserve the integrity of the Mechano Growth &period; Unlike the naturally produced Mechano Growth &comma; the injected MGF needs to enter the circulatory system&period; That is where the problem for the MGF arises&period; MGF is not stable in such environment and in order to be able to reach its final destination and fulfill its role it needs to be PEGylated &lpar;and turned into PEG-MGF&rpar;&period; Polyethylene Glycol serves as a kind of a shell protecting the MGF from reacting to its surroundings before it reaches its final destination&period; It makes the PEG-MGF much more stable and long-lasting than Machano Growth could be on its own&period;

PEG MGF Dosage&colon;

Typical dosage of PEG-MGF is between 200mcg&period; - 400mcg&period; per week but many bodybuilders have said to "research" this peptide at dosages exceeding 1&comma;500 mcg weekly with no adverse effects&period;

Because PEG MGF can cause site specific muscle growth&comma; it is recommended to inject PEG MGF bi-laterally to ensure symmetrical gains&period; The most effective test results were experienced in users injecting the PEG MGF post exercise&period;

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