The principal company of Equity actors will be made up of Jelani Alladin (Hercules), Jeff Hiller (Panic), James Monroe Iglehart (Phil), Ramona Keller (Thalia), Tamika Lawrence (Calliope), Krysta Rodriguez (Meg), and Rema Webb (Terpsichore). Roger Bart, who provided the singing voice of Hercules onscreen, will play Hades. Broadway Inspirational Voices will also take part, providing a special performance, with cameo group performances by 10 Hairy Legs and Passaic High School Marching Band.

The Public Works community partner organizations are Brownsville Recreation Center (Brooklyn), Center for Family Life in Sunset Park (Brooklyn), DreamYard (Bronx), The Fortune Society (Queens), and Military Resilience Foundation (all boroughs), along with alumni partners Casita Maria Center for Arts and Education (Bronx), Children's Aid (all boroughs), and Domestic Workers United (all boroughs).

With music by Alan Menken, lyrics by David Zippel, a book by Kristoffer Diaz, and direction by Lear deBessonet, Hercules will have choreography by Chase Brock, scenic design by Dane Laffrey, costume design by Andrea Hood, lighting design by Tyler Micoleau, sound design by Kai Harada and Jessica Paz, wigs, hair, and makeup design by Cookie Jordan, puppet design by James Ortiz, music supervision and arrangements by Michael Kosarin, orchestrations by Danny Troob and Joseph Joubert, dance arrangements by Mark Hummel, and synthesizer programming by Randy Cohen.