This case was registered by CBI on 6 August 2015 against 12 accused persons following the 9 July 2015 orders of the Supreme Court of India. CBI took over the investigation of FIR No. 270/2009 earlier registered at the Cantonment Police Station of Guna in Madhya Pradesh. The State Police had filed chargesheet against four accused persons and a supplementary chargesheet on 25 March 2015 against a middleman. Further investigation against the accused candidates was kept open by the Local Police.

During investigation by CBI, it was found that the accused candidates were involved in conspiracy with middlemen and the impersonators to cheat during the 2009 PMT examination by making impersonators to appear in the examination on their behalf.

Further investigation against others is kept open under Section 173 (8) of Cr.P.C.

The VYAPAM scam involving the Madhya Pradesh State Professional Examination Board revolves around massive irregularities in medical admission tests and recruitment of staff for many state departments, including contractual teachers and transport constables.

In July 2015, the Supreme Court of India had ordered the transfer of the Vyapam scam case and investigations into the deaths linked with this case to the Central Bureau of Investigation (CBI). The order had come in response to a petition by Congress general secretary Digvijay Singh and a few whistle blowers who were raising this matter for a long time.