The legislation lifts some limits on Medicaid paying for care at addiction treatment facilities, and cracks down on illicit opioids being imported by mail from other countries that add to the epidemic.

The bill passed the Senate, 98-1, earlier this month, with Sen. Mike Lee (R-Utah) the only senator to vote in opposition.

A White House spokesperson confirmed to The Hill that Trump will deliver remarks and sign the legislation on Wednesday.

The discussion on the opioid crisis comes after Health and Human Services Secretary (HHS) Alex Azar said Tuesday that the number of drug overdose deaths in the U.S. have begun to level off.