And now to another difficult scene tonight playing now to two separate American highways. In each case, drivers some how missing those warning signing and getting on the highway going the wrong way. In one instance, a witness, another driver with a camera in her car. She could not believe what was playing out right in front of her. We warn you, the images are not easy. Tonight, ABC's bazi kanani. What is he doing? Reporter: A driver in such disbelief -- Am I being mind Right now? Reporter: She pulls out her cell phone to record an SUV swerving through oncoming traffic this morning on interstate 275 near Tampa, Florida. In a few more seconds, it ends horrifically. The wrong way driver dying after slamming head-on into a car of college kids. Four fraternity brothers also killed instantly. Here in California, less than three hours later, a driver went right past these warning signs onto the Pomona highway. Three vehicles mangled, six dead. A wreck so bad, investigators still don't know which vehicles most of the victims were riding in. Our hearts go out to the families. Reporter: Wrong way driving causes just 3% of U.S. Highway crashes, but they are deadly. Up to 27 times more likely to be fatal, killing an average of 360 people each year. Those wrong way signs often missed when drivers are too impaired to even notice them. Across the nation, 60% of wrong way crashes are caused by drunk driving. Investigators are still looking into whether that's what caused today's accidents.

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