1969 – Western terminus moved to 3½ south of Ravenna, and routed along new bypass route to 3 miles (4.8 km) east of Ravenna; former alignment from Wooster to State Route 21 certified as State Route 585; former alignment from 3 miles (4.8 km) south of Cuyahoga Falls to 3 miles (4.8 km) east of Ravenna certified as State Route 59.[2]

unknown – Realigned from 3 miles (4.8 km) east of Ravenna to 7 miles (11 km) west of Warren.[2]

1970 – Warren Bypass completed from U.S. Route 422 to 3 miles (4.8 km) northeast of Warren (Elm Road) and certified as State Route 5B.[2]

1926 – Truncated at Delphos and 5 miles (8.0 km) west of Wooster; Indiana to Delphos and 5 miles (8.0 km) west of Wooster to East Liverpool certified as U.S. Route 30; East Liverpool to Pennsylvania certified as State Route 39; Mansfield to Ashland dually certified as U.S. Route 42 and State Route 5; Ashland to 5 miles (8.0 km) west of Wooster dually certified as State Routes 5 and 6.[2]

1929 – State Route 5 dual certification removed from U.S. Route 42 and State Route 6.[4]