Sam and Dean end up in Blue Earth, Minnesota, a town surrounded by demons. The locals are putting up a fight under the direction of Leah, the daughter of the local preacher. Leah is a prophet and hears messages from the angels, who tell her where the demons are planning to strike. Sam and Dean assist with an attack against one of the demons' bases that was located with her information. Things start getting fishy when, at the funeral of a local teenager, Leah announces that the town has been chosen and that everyone will enter Paradise on Judgement Day as long as they do what the angels command. She then issues a few commandments: no drinking, no gambling, no premarital sex. Sam is suspicious, but can't get Dean to care.

Leah tells the townspeople that the angels are angry because not everyone is following their commandments. An angry mob attacks Paul, the local bartender. Dean and the preacher try to protect him, but he winds up getting shot. Meanwhile, Castiel finally shows up, completely smashed, and tells Sam that Leah is not really a prophet. She is the Whore of Babylon, a monster who tries to condemn as many souls to Hell as possible. She can only be killed by a true servant of Heaven. Of course, neither Dean, Sam, nor Cas fit that bill, so they enlist the help of the preacher. But in the fight, Dean winds up being the one to stab Leah, and she dies.

Sam is concerned that this means Dean is planning to say yes to Michael. Dean assures him that he isn't, but then slips away and visits [[Recap/SupernaturalS03E02TheKidsAreAlright Lisa]]. He tells her that things are about to get very bad over the next few days, but that he's "making arrangements" so she and Ben will be okay. Lisa asks him to stay but he leaves.

!!Body count For this episode = 20 demons, 2 humans and the whore of Babylon.

* BadassPreacher* {{BFG}}: A fire truck spraying holy water.* BurnTheWitch: Played with--Leah orders the sinners be locked in a storeroom and burned.* ChristianityIsCatholic: Averted. They're Lutheran.* CrisisOfFaith* DarkMessiah* DeadpanSnarker-->'''Jane:''' I don't understand. How are we to get to Paradise now?-->'''Dean:''' I think you're headed in the other direction.* DespairEventHorizon: Cas (from the [[Recap/SupernaturalS05E16DarkSideOfTheMoon last episode]]) and Dean.* DoesThisRemindYouOfAnything* DrowningMySorrows: Cas found a liquor store. And he drank it.* FaceOfAnAngelMindOfADemon: A more literal example than usual.* FunnyAnsweringMachine: Castiel's.-->You have reached the voice mail of [I don't understand. Why--why do you want me to say my name?] [sound of numbers being pressed] [beep].** Castiel also complains about Sam's voicemail being "too long, and the sound of your voice is grating." From the numerous times we've heard Sam's message over the course of the series, it's not particularly long. At the time, Castiel had recently drunk a liquor store, so his irritation and perception of a grating voice could have just been an utterly massive hangover. * TheyWereHoldingYouBack: Paul.* LostInTranslation: "It's funnier in Enochian."* MeaningfulName: Think about the song that the title of this episode is based on. It makes a lot of sense when you find out that Leia is the Whore of Babylon.** Also, this is the 99th episode.* TheMirrorShowsYourTrueSelf* NeverGetsDrunk: Cas is a type 3--he requires a massive amount of alcohol to feel its effects because he's an angel.* NoExceptYes* NotHelpingYourCase: A hungover Cas telling the preacher he's an angel.* NotHerself* ScamReligion* {{Seer}}: Only she's not.* ShapeshifterGuiltTrip* ShootTheDog* UtopiaJustifiesTheMeans* WartimeWedding: Eight in the past week.* WhamLine: "Don't be so sure, whore."