Every Starfleet encounter with a single cube resulted in heavy losses. At the Battle of Wolf 359 in 2366, an armada of forty Starfleet ships was assembled to stop a cube; thirty nine ships were lost. Dozens more were destroyed stopping another cube in the incursion of 2373. (TNG: "The Drumhead"; Star Trek: First Contact) Normally a single Borg cube was capable of assimilating all elements of civilization from an entire planet.

Millions of cubes were estimated to exist in Borg space in the Delta Quadrant; the largest single grouping of cubes directly observed by Starfleet was fifteen, by the crew of the USS Voyager in late 2373. (VOY: "Scorpion") When describing the assimilation of his world, Arturis said that hundreds of cubes surrounded his homeworld before its destruction. (VOY: "Hope and Fear") Seven of Nine stated to Captain Janeway that the nebula concealing the transwarp hub contained at least 47 Borg vessels. (VOY: "Endgame")

Another tactic used to disable vessels fleeing a cube was to fire a type of missile weapon. Three missiles were capable of disabling a Galaxy-class's shields. A hit from the weapon at an unshielded target could disable its warp drive. (TNG: "Q Who")

Ships up to the size of a Borg sphere were able to be docked inside a Borg cube for assimilation, supplies or escape purposes.

At least one Borg cube, and possibly others of its class, contained a Borg sphere. The only known recorded purpose of a sphere disengaged from a Borg cube was for escape. The sphere is the only documented support vehicle a Borg cube possessed. (Star Trek: First Contact)

Borg cubes were highly decentralized in structure with no specific bridge, living quarters or engineering sections. All vital systems were spread throughout the ship, which, along with the presence of a regenerative hull, made it highly resistant to damage and system failures. (TNG: "Q Who")

Borg cubes make appearances in the Star Trek: Armada and Star Trek: Armada II games. In the second game, a "fusion cube" and "tactical fusion cube" are seen, and used by those playing as the Borg. The first consists of eight regular cubes connected to each other and is the size of a planetoid, such as Pluto. The second is composed of 8 tactical cubes connected to each other and is the size of a planet, such as Mars. Both are designated battleships and hold the assimilator beam device and three "captured" special weapons taken from an enemy race.