Modafinil and Blood Pressure | Should You Be Concerned?

I’ve never had issues with blood pressure. I’m a young, relatively healthy guy. It’s just not one of my main concerns. However, when researching side effects, I was a bit alarmed. Apparently, Modafinil and blood pressure aren’t a match made in heaven.

Before I bought Modafinil for the first time, I was generally concerned about the smart drug’s effect on blood pressure.

No mid-20s guy wants to deal with hypertension. That’s just not preferable.

While the concerns about Modafinil and blood pressure were justified, I went ahead and ordered Modafinil online. The small chance my blood pressure would be influenced was outweighed by the benefits of Modafinil.

Luckily, I’ve never experienced any changes in blood pressure when taking Modafinil – recently confirmed by a trip to the doctor for my yearly physical.

Modafinil didn’t change my blood pressure at all. Still, you’ll want to learn a little more about Modafinil and blood pressure before deciding whether to use the smart drug or not.

That’s why I’m writing this article. Below you’ll find everything you need to know about Modafinil and blood pressure, including various studies and their results. While I’m no doctor, my goal is to educate you on the potential side effect of Modafinil

P.S: It should come as no surprise that I’m not a doctor or a lawyer. This is not legal or medical advice. The information presented on this site is purely entertainment. Always consult a medical professional before consuming any nootropics, like Modafinil. Nomadic Hustle and/or Jake is not legally liable for the content on this site if you rely on the presented information – in any which way. Please read my disclaimer.

What is Modafinil?

Before we dive into Modafinil and blood pressure, let’s talk about exactly what this smart drug is and why it’s so popular these days.

Modafinil was originally developed as a pharmaceutical drug to treat ailments like narcolepsy, sleep apnea, and shift sleep disorder (Source). Essentially, the drug was created as a wakefulness agent.

Developed under the name Provigil, the nootropic quickly gained a following from anyone looking for a little mental boost.

People like CEOs, Wall Street professionals, grad students, and more began using the smart drug to improve their mental performance. Modafinil offered huge cognitive benefits like:

Improved cognition

Increased focus

12+ hours half-life

Improved memory and retention

…And more!

Suffice to say, anyone looking to improve their mental performance found 12+ hours of superhuman focus and energy when taking Modafinil. The smart drug spread like wildfire!

Today, many people from all walks of life take smart drugs like Modafinil to help them make more money, get better grades, or simply function at a higher mental capacity.

Short-term administration of modafinil did not elicit a significant response with regard to the main end point. However, cardiovascular effects during mental and physical load were observed. Longterm studies that include subjects with hypertension are necessary to investigate the clinical relevance of the cardiovascular effects of modafinil (Source).

What does this mean? Basically, this study shows that Modafinil did not offer a significant change in blood pressure during short-term usage – unless the subjects were under mental and physical loads.

Basically, if the subjects did not have to take a mental or physical performance test, then significant changes in blood pressure were not shown.

– Study #2: Modafinil Elicits Sympathomedullary Activation –

This study looked at the effects of Modafinil on the nervous system as a whole. The results were interesting, but it should be noted that patients were taking 400 mg of Modafinil a day, every day.

Most smart drug users take 200 mg Modafinil or less, and these users take the smart drug 1-3 times per week.

Still, according to this study, Modafinil and blood pressure is not a match made in heaven:

In conclusion, modafinil causes a strong central adrenergic response, as indicated by increased levels of catecholamines (plasma NE, dopa, DOPAC, urinary NE, and Epi), HR, and BP. This is attributable in part to adenomedullary discharge, as evidenced by increased Epi excretion. We attempted to study an equal number of males and females, but because of non–study-related (personal) circumstances, 10 males and only 2 females completed the study. Because of potential differences in many measures under investigation, it would be wise to conduct a study with an equal number of men and women.

Although this is a cross-over design in which each subject acted as his/her own control, interpretation is limited by its small sample size, which permits detection of only large effects; some effects of interventions could be missed, and effects reported here might, therefore, be considered large amplitude. A long-term influence on BP cannot be extrapolated from a single-dose treatment. Studies of the long-term treatment of patients with concomitant cardiovascular diseases (eg, hypertension) with modafinil should include measurement of cardiovascular parameters. Such a study is desirable to evaluate modafinil compared with substances such as caffeine or amphetamines, which are known to have profound effects on the cardiovascular system (Source).

This study shows Modafinil negatively affects blood pressure, along with other aspects of the cardiovascular system.

That being said…

The researchers acknowledge that Modafinil may not have profound effects on the nervous system when compared with other stimulants, such as caffeine (Source).

Should You Be Concerned?

While Modafinil and blood pressure isn’t the ideal combination, neither is caffeine and blood pressure.

Every stimulant can cause changes in blood pressure, especially if the individual is prone to cardiovascular issues.

Overall, if you’re a healthy adult under the age of 45, then Modafinil and blood pressure shouldn’t be a huge concern.

If you have cardiovascular issues, then that’s a completely different story.

Still, it’s always a good idea to check with a medical professional before you start taking Modafinil, as I’m no doctor and this article is not medical advice.

Jake has been utilizing nootropics, like Modafinil and Phenibut, for the better part of a decade. Once he realized the potent results these products produce with regards to productivity and cognitive enhancement, he became obsessed at finding the premier smart drugs on the market. Then using them to improve his life. When he's not devouring everything he can about nootropics and the science behind why they work, you'll find him traveling around the world or in the gym.

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I am not a doctor or a lawyer. This is not legal or medical advice. This guide/article is strictly for entertainment. Always consult a medical professional before consuming any nootropic, like Modafinil. Always abide by the laws of your country. Oh, and please read my disclaimer page, too.

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