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MTA is valid for the academic year. (January 10th, 2012)

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June, 2017

The axon trajectories of adult Ciona was described. In this report, NBRP the transgenic lines expressing Kaede in the neurons were used. Click here for details.
Click here for details.

May, 2017

The functions of Hox1 in the thyroid-homologous organ (endostyle) were characterized in Ciona.
In this report, TALENs for famous developmentally relevant genes like Otx, Hox1, RAR and Raldh2 were created.
These TALENs are available from NBRP.
Click here for details.

A novel technique to establish Ciona mutant lines has been established.
This technique utilizes TALEN-based genome editing and germ cell regeneration.
In this report, new vector series that can monitor TALEN expression with the aid of mCherry fluorescence were created,
and these vectors are now available from NBRP.
Click here for details.

December, 2016

Evolution of the epidermis-specific expression of the gene encoding cellulose synthase of Ciona intestinalis was investigated with the genome editing technology. This provides a novel insight into the mechanisms of horizontal gene transfer. Click here for details.

April, 2016

A unique regulation of cell cycle compensation in the epidermal cells of Ciona neurula embryos was described. The regulation is essential for synchronous mitoses during embryogenesis. Many novel DNA constructs were used in this study, which have been added in this database. Click here for details.

November, 2015

The neuronal map of the central nervous system of Ciona juvenile was described in detail. Many transgenic lines in the NBRP project were used. Moreover, this manuscript provides the first report of the optogenetics in ascidian. Click here for details.

July, 2015

The function of Hox10 has been revealed in Ciona intestinalis. TALENs and enhancer trap lines of the NBRP were used in this study. Click here for details.

January, 2015

The international rules of the nomenclature of ascidian genetic resources (including transgenes and transgenic lines) were reported. Click here for details.

About Ciona Intestinalis Transgenic line RESources

Fig: Ciona intestinalis

In addition to their unique evolutionary position as invertebrate chordates, ascidians provide a simple experimental system to investigate molecular mechanisms underlying development, reproduction, endocrinology, and physiology.

Contact Information

Shimoda Marine Research Center, University of TsukubaYasunori Sasakura