“For me it was a completely new subject that I had never heard of before,” the 13-year-old says.

The talk inspired her to create this drawing (click on it to see a larger version), a cross between a comic strip and a movie storyboard. While the star of the image is named “Jennifer Brain,” she closely resembles real-life TED speaker Susan Solomon, who at TEDGlobal 2012 shared the advances being made toward creating lab-grown stem cell lines, which could accelerate many types of medical research.

Matei’s teacher, Joseph Leonetti, handpicked this talk to kick off a special project for his students — as they did a three-week lesson on cell structures and processes in class, they were tasked with researching stem cells at home. “They were responsible for finding out what stem cells are, where they come from, how they are used and the ethical issues surrounding them. They were guided in the right direction,” he says. “Almost each class session started with students eagerly discussing what they had found out about stem cells the night before.”

This image was one of Matei’s homework assignments from the lesson. She walks us through the action of it: “Famous scientist Dr. Brain is invited to give a TED Talk about her studies,” she says. “She’s trying to convince people that stem cell research could help cure many diseases.”

In general, Matei says that her favorite subjects in school are math, English and, of course, science. “I loved every lab and experiment in Mr. Leonetti’s class,” she says. As for her favorite TED Talks she prefers ones “about new technological inventions.”

So we’ll have to wait and see what’s next for Dr. Jennifer Brain.

Fanfare shares art, music, video remixes and more created by TED fans around our content. Have something you’d like to share? Write kate@ted.com and tell her about it.

]]>http://blog.ted.com/meet-jennifer-brain-your-new-favorite-ted-speaker/feed/0StemCellsCecilia-(1)katetedLooking into the future: A stem cell development to cure blindness, plus a playlist of visionary talkshttp://blog.ted.com/looking-into-the-future-a-stem-cell-development-to-cure-blindness-plus-a-playlist-of-visionary-talks/
http://blog.ted.com/looking-into-the-future-a-stem-cell-development-to-cure-blindness-plus-a-playlist-of-visionary-talks/#commentsThu, 25 Jul 2013 21:42:27 +0000http://blog.ted.com/?p=80361[…]]]>Scientists in London have achieved a significant breakthrough on the road to curing blindness this week.

Certain kinds of blindness are caused when photoreceptors — the cells in the retina that react with light and send an electrical signal to the brain — die off. Researchers at Moorfields Eye Hospital and University College London have, for the first time, created a technique to transform stem cells into photoreceptors and inject them into the eyes of mice. The BBC reports that studies of this technique in humans are not terribly far off. Says lead researcher Robin Ali, “Five years is a now a realistic aim for starting a clinical trial.”

“To restore vision, safely and effectively, is an enormous challenge,” she tells the TED Blog. “We are incredibly excited by the British group’s advance in creating working photoreceptors from stem cells. However, many eye diseases do not discriminate between cell type, resulting in tissue-wide damage. At NYSCF, we enable work that complements the British group’s advance. Our collaborators have been applying similar techniques to create the eye cells supportive of photoreceptors.”

To celebrate this development towards the restoration of vision, below a playlist of talks on blindness and sight — from a car for blind drivers to a new way to experience color.

Pawan Sinha: How brains learn to see
Pawan Sinha on how brains learn to see
Pawan Sinha gives blind children the gift of sight. In this talk from TEDIndia 2009, Sinha details his research on the development of the brain’s visual system, offering insight into neuroscience and engineering, as well as into autism. Sinha and his research team provide free vision-restoring treatment to children born blind, and then study how their brains interpret this new visual data.

Neil Harbisson: I listen to color
Neil Harbisson: I listen to color
Artist Neil Harbisson experiences color through sound. Born completely color blind, Harbisson now wears a device attached to his head that allows him to perceive the world around him in a symphony of color, listening to faces, paintings and colors beyond the range of sight.

Will the next generation think about diseases like Alzheimer’s and diabetes the way we think about polio and the whooping cough? Susan Solomon, the co-founder of the New York Stem Cell Foundation (NYSCF), certainly hopes so. In this fascinating talk from TEDGlobal 2012, Solomon delves into the foundation’s work on research with stem cells, which she calls the “black boxes for diseases.”

“[Stem cells] are our bodies’ own repair kits. They are pluripotent, which means they can morph into all of the cells in our bodies,” says Solomon. “Right now there are some really extraordinary things that we are doing with stem cells that are completely changing the way we model disease, our ability to understand why we get sick and even develop drugs. But … this field has been under siege, politically and financially.”

While much of the fray is about embryonic stem cells — still the gold standard when it comes to cells — Solomon explains that another type of pluripotent stem cell (called iPS cells) can now be created by, essentially, reprogramming skin cells. These cells hold great promise for allowing researchers to see how diseases develop in humans, rather than in rodents.

Currently, developing a drug takes an average of 13 years, costs $4 billion, and has a 99% failure rate. And because it’s impossible to test a new drug on a large and representative sample of the human population, even a drug that tests well with many people will have side-effects for others, based on their genetic makeup. This is a problem that’s sometimes not apparent until the drug is on the market and being prescribed to patients — like in the tragic case of Vioxx.

“That’s a terrible business model, but also is a horrible social model,” she says. “The way we’ve been developing drugs is essentially like going into a shoe store and no one asking what size you are … They just say, ‘Well, you have feet. Here are shoes.’”

From the TEDGlobal stage, Solomon outlined an exciting new approach—her team at NYSCF has developed a machine that creates stem cell lines that, until now, had to be crafted by hand. NYSCF expects to produce 2,500 stem cell lines by the end of the year. The idea is to eventually produce a comprehensive array of 25,000 stem cell lines — which act like avatars for a wide sample of people — that researchers would have access to as they test new drugs. This could help avoid disasters and also let people know ahead of time of what side-effects they, specifically, can expect with a given medicine.

But Solomon stressed that it will be extremely difficult to change the current systems of drug development.

“All the established companies have been using mouse-and-rodent testing forever,” she said. “A lot of people’s careers are staked to a method that is outdated. It’s like the tech sector; this is really the high-tech sector for biomedical research.”

To hear more about the NYSCF, watch Solomon’s talk. Below, watch 9 more talks about the incredible promise of stem cells.

Susan Lim: Transplant cells, not organsAs a woman, surgeon Susan Lim had to fight for the right to perform the first liver transplant in Asia. But she began to question the morality of such work given that — with donor organs in such short supply — many are coerced or forced to donate. Lim began looking at another approach: transplanting cells, rather than organs. In this talk, given at the INK Conference, she describes her work with adult stem cells derived from fat.

Daniel Kraft invents a better way to harvest bone marrowPediatrician and stem cell researcher Daniel Kraft has created a device to collect bone marrow in a way that is far less painful for both the patient and the doctor. In this talk from TED2009, Kraft shows how the stem cells found in this marrow could be used to treat heart disease and Parkinson’s.

Eva Vertes: Do stem cells cause cancer?Microbiology prodigy Eva Vertes was 19 years old when she spoke at TED2005 about a theory that cancer might be a repair response to damaged stem cells in the lungs, liver, bones, etc. The implication she is testing? “It’s possible, although far-fetched, that in the future we could think of cancer being used as a therapy.”

Alan Russell: The potential of regenerative medicineNot for the squeamish, in this talk from TED2006, medical futurist Alan Russell shows a video of stem cells being removed from a patient’s hip and injected directly into their heart — and how this procedure has gotten much more precise over a short time. Such cell regeneration therapies will keep improving, Russell says.

Noel Bairey Merz: The single biggest health threat women faceWhile heart disease is often thought of as a “male disease,” Noel Bairey Merz explains that it is actually the biggest killer of women. In this talk from TEDxWomen 2011, Merz gives a call to arms for women to think of heart disease in the same way we do breast cancer, and talks about some exciting possibilities for treatment, including stem cell therapy.

Daniel Kraft: Medicine’s future? There’s an app for thatKraft, chair of the FutureMed program at Singularity University, talks about some of the big innovations coming down the pipeline in medicine. Near the end of this talk given at TEDxMaastricht, Kraft talks about cancer stem cells and how understanding them could lead to an era of personalized oncology — “the ability to leverage all of this data together, analyze the tumor and come up with a real, specific cocktail for the individual patient.”

Juan Enriquez: The next species of humanFuturist Juan Enriquez believes that some big changes are coming, and that the next generation of humans could potentially be considered a different species. Why? In this talk from TED2009, he looks at the ability to engineer both cells and tissue, and describes some shocking ways researchers are using stem cells.

Kevin Stone: The bio-future of joint replacementArthritis affects more adults than cancer, says Kevin Stone in this talk from TED2010. While therapies using human tissue have been very promising in helping joint damage, there simply isn’t enough donor tissue to go around. Stone explains a process which uses cartilage from a pig, loaded with a person’s own stem cells, to ease pain and immobility.

Iain Hutchison: Saving facesIn this talk from TEDGlobal 2010 — which contains some images of badly injured and disfigured faces that may be disturbing — facial surgeon Iain Hutchison gives a look at his groundbreaking work. Towards the end of the talk, he describes an promising area of research — tissue engineering — which uses a patient’s own stem cells, taken from their hip, to help heal facial damage.

“We have something that will radically save the pharmaceutical industry,” says Susan Solomon in an interview on the social floor of TEDGlobal 2012, in Edinburg, Scotland. Solomon is the founder and CEO of the New York Stem Cell Foundation. She spoke with the TED Blog about the NYSCF’s new array of automatically created stem-cell lines, which she talked about for the first time onstage at TEDGlobal.

On Wednesday, Solomon gave a talk on the promise of stem cells in research. In that talk, she discussed the process of drug development: it’s spectacularly expensive and time-consuming, taking 13 years and costing around $4 billion for a single drug, which will have a 99% failure rate. “That,” she says in the talk, “is a terrible business model, but also is a horrible social model.”

Part of the problem is, it’s impossible to test a new drug on a large and representative sample of the human population (which would be spectacularly unethical). But it means that a drug that tests well on some people will have side-effects, or be ineffective, on other people — a problem that’s sometimes not apparent until the drug is on the market and being prescribed to real patients. It’s not known exactly why this happens, and it could be due to differences in genes or other unknown factors.

To allow for much broader testing, Solomon and the team at NYSCF have created a machine that can roboticize the creation of stem-cell lines. This will produce a comprehensive array of stem-cells which can serve as a testbed for new drugs, allowing testing on a wide sample of human types. As she said in her talk:

By 2008, a scientist at the NYSCF was able to take skin cells, turn them into stem cells, then into motor neurons — the kinds that are damaged in ALS, or motor-neuron disease. Using that, he could watch the progress of the disease in a dish in living human cells. He found they were dying in very different ways than thought: They were being attacked by other cells. This was not possible to see before the model provided by the stem cells; it would have been like looking at a plane crash before the black box. Says Solomon, “Stem cells are the black box for diseases.”

The idea is that, if researchers had access to 25,000 different stem-cell lines, instead of just a few, they could test new drugs on a wide sample of human stem-cells before releasing it. That would not only avoid disasters like the deaths from adverse reactions to Vioxx, but also give people a sense ahead of time of what side-effects they might experience. “You want to know not just a list of side-effects,” said Solomon, but when looking at a specific side-effect, “Am I that person?”

The new array is built and is already producing stem-cell lines. It will be able to make 2,500 lines by the end of the year, a stunning increase over previous numbers. (In the past, all stem-cell lines were created by hand.) “We have the best stem cell scientists,” Solomon says of the NYSCF, “and we recapitulated their methods in software.” And they’ve designed the machine in a way that can adapt to new developments: “The only thing we know for sure is that techniques will improve.”

The next question: funding. Currently the NYSCF runs one shift on one machine, which produces the 2,500 lines a year. They could increase this by adding shifts or even a second machine — their eventual goal is to produce 25,000 stem-cell lines each year. They also plan to move the machine into a clean-room facility, to enable the lines to be used in research with more stringent requirements.

Solomon and her team are quite excited. “The goal is to change things so that we’re not waiting 13 years to find out a drug doesn’t work, or it harms you.”