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Pros

Pro

Mesh Deformation

Instead of having to change sprites to bend legs or other joints mesh deformation changes the mesh shape based on joint weights to bend and move.

Pro

Inverse Kinematic bones

Bones will move and rotate reacting to the position of the rest of the skeleton. The animator does not have to animate each part of a joint but rather have it follow realistically. Also can be used for ragdoll effects based on physics.

Pro

Built on top of Unity’s animation system

Mecanim and state machines work natively since Puppet2D builds on top of Unity’s built in animation system.

Cons

Con

Forced editor scaling causes problems

Puppet2D adjust the scaling of bones in the editor for display purposes, which results in unintended behavior if other objects use a bone as a parent.