For these purposes we will integrate comprehensive data sets from next generation exome and whole-genome sequencing, ChiP-sequencing, tissue transcriptome and antigen/epitope profiling, and miRNome, proteome/peptidome, and metabolome screening in different body fluids within and across conventional diagnostic categories. These data will be combined in a systems biology approach with high-resolution clinical phenotyping and findings obtained with a large array of established and novel in vitro, ex vivo and in vivo disease models (‘functiomics’) to identify disease-associated genetic variants involved in monogenic or complex genetic transmission, disease-defining molecular signatures, and potential targets for therapeutic intervention. These efforts will converge in the development of innovative diagnostic tools and biomarkers and efficient screening strategies for novel therapeutic agents to improve patient outcomes.

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Kidneys for Life raises money research into kidney disease, transplantation, dialysis and related disease affecting the kidney; direct patient amenities for renal and transplant patients not usually funded; supports education of the renal multi-disciplinary team and patients; support for conferences & workshops relating to kidney disease and the purchase of medical equipment.