Allogeneic Stem Cell Transplantation in Adult Acute Lymphoblastic Leukemia (ALL) patients <50 years old in first complete remission(CR) A Donor vs no donor comparison in the EORTC ALL-3 Study.

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Allo transplant for ALL has been used for over 20 years but despite its' general application its role in adults remains unclear.

The contraversy remains between an allo transplant and an autologous transplant followed by maintenance chemotherapy for this disease in adults.

Materials and Methods

This is an intention to treat analysis that looked at adult ALL patients in CR after induction and consolidation therapy and randomized them to either an allo transplant (those with idenitical sib donors) and autologous transplant followed by maintenance chemotherapy.

340 patients were enrolled.

296 patients had large mediastinal masses

All patients were previously untreated for ALL

T and B cell ALL were included.

Median pt age was 33.

Only 279 pts were younger than 50 and 79% of those attained CR after induction and consolidation therapies.

9.5 year follow up showed that 93 pts had relapsed and 26 died.

Results

10 year Disease Free Survival (DFS) for allo and auto plus maintenance were similar -- 33.9% and 33.8% respectively.

Relapse rates were lower in the pts who underwent allo transplants than those who had auto transplants. 38% for allo vs. 59% for auto.

Jul 25, 2011 - Pediatric patients with high-risk leukemia, either acute myeloid leukemia (AML) or acute lymphoblastic leukemia (ALL), who are treated with contemporary protocols have improved survival compared to earlier cohorts and have a favorable outcome after hematopoietic cell transplantation (HCT), regardless of donor type, according to a study published in the July 14 issue of Blood.