RUGS – ATT (ANTITUBERCULAR TREATMENT) There are 3 main properties of antituberculous drugs:

1. Bactericidal action

2 Sterilizing activity

3-To prevent resistance.

The first line agents consist of Isoniazid, Rifampin, Pyrazinamide, Ethambutol.

These drugs are given orally, once a day.

Peak level is at 4 hours and effect lasts for 24 hours. Second line drugs have lower efficacy and more toxicity. These are streptomycin, kanamycin, amikacin, capreomycin, ethionamide, cycloserine, and PAS(Paraamino salicylic acid).

Isoniazid, Pyrazinamide, Rifampicin, and rarely Etham­butol can damage the liver.

When a patient develops hepatitis during tubercular treatment, all An should be stopped till liver func­tion tests become normal, or An is not given for 2 weeks after jaundice has disappeared. Rifampicin can give rise to jaundice without hepatitis and symptoms.

For patients with drug-induced hepatitis Streptomy­cin, and Ethambutol may be given.

Anti Tuburculous Drug Isoniazid

• Highly bactericidal

· Given orally (1M also available)

· Dose 5 mgjkg or 300 mgjday

· Preventive dose 300 mgjday for 6 months

· Contraindications – Active liver disease,

Hypersensitivity.

In malnutrition, alcoholics, and diabetics, patient should be given pyridoxine 10 mgjday with Isoniazid.

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My baby was given 4 month intensive treatment (3 drugs RHZ) instead of two month.Baby was 10 kg in wt at the time of start of treatment now she is 11 kg. My concern is what are the side effects of treatment and what should I do to minimize them.

sir my mother is taking HRZE every morning empty stomach daily for wrist joint tb started since 20 days,now complaing of epigastric pain and giddiness after taking drugs,not able to contact her consulting dr as she is out of stn..kindly advice?

I am a TB patient taking medicine for TB ,last april 10 th my medications two month finished, the starting medicines are RCnex 650,ethmbatol-800, PZA-750 BD and benedone-20. after april 10 only iam takinig RCnrx-650 and benedone- 20 Is it correct medication? Can i continue this. How long time i have to take.

my father aged 62 yrs getting Att treatment just started 4 days ago,he was suffering from fever long time(2 months) ,doctor at first treated with inj pipercillin with tazobactom after the failure of oflox and cefixime orally,patient few days after feel good ,but problem of fever came again then he treated with gram + antibiotic linezolide,after completing 6 days course patient became well and he finaly discharged from hospital with Att regimen as dr suggested ,my father has a history of TB 30 yrs ago,,,my father also has got a 4.3×3.3 cm size cyst in left kidney detected 15 days ago,dr suggested it would not create any problem,,,,,Now my father taking ATT regimen of first two months still suffering from fever ,my Q is why fever is coming again? is it common until medication is not completed/ please suggest.