35 years ago, over Easter weekend in April of 1982, Professor Barry Marshall cultured H.pylori from patients with gastritis and ulcers for the first time, after Robyn Warren, a pathologist, observed the previously unknown spiral- shaped bug in stomach lining biopsies. Prior to their discovery, it was dogma that the stomach was a sterile environment and that stress caused ulcers. Today, Professor Marshall is the director of the Marshall Centre for Infectious Diseases Research and Training at the University of Western Australia. He recently spoke with JAMA about his historic discovery, how he plans to use H.pylori to prevent disease, and the greatest rewards from his life’s work. The interview with Professor Marshall on the eve of the 35th anniversary of helicobacter is available online at: http://jamanetwork.com/journals/jama/fullarticle/2616393?widget=personalizedcontent&previousarticle=182574