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Online Cover This week features a Research Article that identified a polyunsaturated fatty acid (PUFA) and a receptor that contribute to abdominal pain in a mouse model of irritable bowel syndrome (IBS). The authors found that the PUFA 5-oxoETE was more abundant in the colons of IBS patients with constipation than in those of healthy donors, that 5-oxoETE induced pain in mice, and that mice deficient in the receptor Mrgprd were less sensitive to the effects of 5-oxoETE. The image shows a mouse dorsal root ganglion expressing Mrgprd (green). [Image: Bautzova et al./Science Signaling]