Use Cases and Sample Reports

Dysautonomia and GI troubles

This patient expressed that they were diagnosed with Dysautonomia and Hashimotos Thyrroiditis and that they were currently dealing with severe headaches, fainting, and numerous stomach problems with no known association to a specific food. We built the genetic panel around potential underlying causes of dysautonomia and GI issues. After building the functional polygenic networks around the symptoms, we found some disrupting genetic patterns around Celiac Disease, IBS, and autoimmune inflammation. We also found patterns surrounding liver function and fat utilization as well as possible nutrient deficiencies and a potential inability to digest oligosaccharides found in food processing leading to a possible benefit in FODMAP diet implementation.

In this report, the patient reported multiple symptoms and related them to EMF exposure. We built this genetic report around possible underlying causes of EMF sensitivities and developed functional polygenic networks related to damage from EMF/ EHS/ UV exposures. After running the report, we found some interesting genetic patterns involving mitochondrial ETC, autophagy/ apoptosis, and cell homeostasis. We also found patterns that showed possible higher than normal susceptibility to oxidative stress as well as potentially inefficient immune regulation due to some rare variants in this person’s HLA genes.

In this report the practitioner gave us a summary of concerns to look at, mostly concerning heart health but the practitioner also wanted to check out some other symptoms/concerns such as mitochondrial disorders, neurodegenerative disorders, tremors, ataxia, and muscle tightness and weakness. This report was built around the listed concerns with a heavy emphasis on cardiovascular health. The biggest genetic patterns that popped up surrounded possible pancreatic disfunction so we pointed out possible connections between pancreatic function and heart health. We also found patterns in autophagy, thyroid, fat metabolism and a variant in LMNA with direct connection to dilated cardiomyopathy risk. This result also seemed to have many more mitochondrial variants than average so we pointed out some possible concern in mitochondrial disease risks. This result also includes mitochondrial DNA variants.

GeneSavvy Reports

*Our current estimated turn around time is 10-14 weeks for GeneSavvy Starter Kit Testing. GeneSavvy reports are generally delivered within 24 hours. Starter Kit Testing turn around time estimate can vary based on our current testing volume, sample DNA quality, or DNA extraction issues that might happen during the DNA sequencing process.

What Makes Our Results
More Actionable?

Functional Polygenic Networks

Genes interact with each other! We work hard to take upstream, downstream and co-factor interactions into consideration when looking at how genes contribute to our health concerns.

We build comprehensive genetic networks surrounding diseases, biological functions, and more to help identify possible targets for clinical action. We look to identify rare, high impact gene variants that are shared across multiple networks as possible root causes behind complex health conditions.

Less Data Filtering

One of the biggest reasons we started GeneSavvy was because we wanted to build a system that gave us more access to more data without a filter.

A lot of the genetic information used for the health industry comes HEAVILY filtered to us. Some of the reasoning is OK such as filtering out misaligned data that isn’t real. Most of the time filtering is done to “protect” us from seeing data that someone, somewhere thinks we just cant comprehend or that they think its junk data so theres no point in sharing it. We work hard to filter out data that isn’t real, but we also work hard to keep the data that is real available to access, research, and include in our theories if we think theres a potential correlation there to explore.

We Listen To The Story Your Genes Are Telling Us!

When you tell a doctor your symptoms they will automatically create a hypothesis about whats going on. We do the same with your genetic results, but what if your genes present a hypothesis we’ve never seen before?

Actually we see this scenario all the time in functional medicine and it gets ignored way to often! A person fighting so hard to tell someone that something is wrong, many times their story gets ignored or even mocked because it doesn’t line up with what we think we know. Our job isn’t to mold the data into something that fits our hypothesis or current way of thinking. Our job is to let the data tell its own story and for us to listen and support the systems that show patterns of genetic disruption.

More Functional Data Enrichment for Better Health Actionability

Data enrichment is all about associations. Showing gene relationships to cellular functions, molecular functions, drugs, diseases, etc… are all examples of data enrichment.

Our roots are in functional medicine, so our enrichment data is geared around terms that functional health practitioners can relate to and create action around. On top of the standard enrichment terms, we are also building our own custom enrichment database of truly functional and actionable gene associations. Our own enrichment database includes a gene to custom pathway diagrams, gene to food/nutrient associations, gene to lifestyle associations, gene to environment associations, gene to vitamin/herb associations, and more.

Gene to Pathway

Gene to Food/Nutrients

Gene to Lifestyle

Gene to Environment

Gene to Vitamin/Herb

Gene to Underlying Cause

GeneSavvy Functional Medicine Enrichment Databases

*Not all genes are enriched by our database. Our database will grow as research grows.

GeneSavvy is Fueled by Insatiable Curiosity!

Our greatest feature is our level of insatiable curiosity that drives our ability to find answers when nobody else can or will.

We are here to help find answers and provide actionable data that leads to longer, more vibrant life…

We’ve opened Pandora’s Box and released genetic curiosity, all we can do now is share the gift of hope for a healthier future that came from within that same box.