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Abstract

In this paper, we demonstrate for the first time that the detailed cutaneous blood flow at capillary level within dermis of human skin can be imaged by optical micro-angiography (OMAG) technique. A novel scanning protocol, i.e. fast B scan mode is used to achieve the capillary flow imaging. We employ a 1310nm system to scan the skin tissue at an imaging rate of 300 frames per second, which requires only ~5 sec to complete one 3D imaging of capillary blood flow within skin. The technique is sensitive enough to image the very slow blood flows at ~4 μm/sec. The promising results show a great potential of OMAG’s role in the diagnosis, treatment and management of human skin diseases.

, Assessment of UHS-OMAG sensitivity to the flow as compared to PRODT. (A) velocity image obtained from the flow phantom assessed by UHS-OMAG, (B) plot of the velocity data across the capillary tube at the position shown as the blue line in (A). (C) and (D) are the corresponding results obtained by PRODT imaging of the same phantom, respectively. White bar = 500 μm.