An exercise physiologist wants to examine whether stretching and wearing ankle weights affect the value of exercise on treadmills. To carry out her study, she recruits subjects who have roughly the same level of physical fitness, and divides them randomly into four groups: with or without ankle weighs, and with or without a stretching period before the exercise.

Using the amount of calories burned as the response, carry out a two-way ANOVA to determine whether stretching and wearing ankle weights have significant effects on exercise.