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{\*\bkmkstart filing_1}{\*\bkmkend filing_1}{\*\bkmkstart doc_1_1}{\*\bkmkend doc_1_1}\pard\plain\ul{\field{\*\fldinst HYPERLINK \\l "tableofcontents_12906402" }{\*\fldrslt\cf3\f51\fs20\ql Table of Contents}}\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\brdrb\brdrs\cf1\f51\fs2\ql \~\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs36\b\qc UNITED STATES\par\pard\plain\cf1\f51\fs36\b\qc SECURITIES AND EXCHANGE COMMISSION\par\pard\plain\cf1\f51\fs20\b\qc Washington D.C. 20549\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs36\b\qc FORM\~10-Q\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\ql (Mark One)\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\li550\fi-264\cf1\f54\fs24\b\ql x\plain\li550\cf1\f51\fs6\ql \~\~\~\~\~\plain\li550\cf1\f51\fs24\b\ql QUARTERLY REPORT PURSUANT TO SECTION\~13 OR 15(d)\~OF THE SECURITIES\plain\li550\cf1\f51\fs24\b\ql EXCHANGE ACT OF 1934\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\qc For the quarterly period ended March\~31, 2019\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\qc OR\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\li550\fi-264\cf1\f54\fs24\b\ql o\plain\li550\cf1\f51\fs6\ql \~\~\~\~\~\~\~\~\plain\li550\cf1\f51\fs24\b\ql TRANSITION REPORT PURSUANT TO SECTION\~13 OR 15(d)\~OF THE SECURITIES\plain\li550\cf1\f51\fs24\b\ql EXCHANGE ACT OF 1934\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\qc For the transition period from \~\~\~\~ to\par\pard\plain\cf1\f51\fs20\qc \~\par\pard\plain\cf1\f51\fs20\b\qc Commission file number:\~001-37990\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs36\b\qc LEAP THERAPEUTICS,\~INC.\par\pard\plain\cf1\f51\fs20\qc (Exact name of registrant as specified in its charter)\par\pard\plain\cf1\f51\fs20\ql \~
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\pard\plain\intbl\cf1\f51\fs20\b\qc 47 Thorndike St, Suite\~B1-1, Cambridge, MA\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\b\qc 02141\cell{
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\pard\plain\intbl\cf1\f51\fs20\qc Address of Principal Executive Offices\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qc Zip Code\cell{
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\pard\plain\intbl\cf1\f51\fs20\qc Common Stock, par value $0.001 per share\cell\pard\plain\intbl\cf1\f51\fs2\qc \~\cell\pard\plain\intbl\cf1\f51\fs20\qc LPTX\cell\pard\plain\intbl\cf1\f51\fs2\qc \~\cell\pard\plain\intbl\cf1\f51\fs20\qc Nasdaq Global Market\cell\pard\plain\intbl\cf1\f51\fs2\qc \~\cell{
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\pard\plain\intbl\cf1\f51\fs2\qc \~\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qc Emerging growth company\~\plain\intbl\cf1\f54\fs20\qc x\cell{
{\trowd\trqc\cellx5292\clvertalb\cellx5507\cellx10800\trrh248\row}}}\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\ql If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for\plain\cf1\f51\fs20\ql complying with any new or revised financial accounting standards provided pursuant to Section\~13(a)\~of the Exchange Act.\~\~\~\plain\cf1\f54\fs20\ql o\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\ql Indicate by check mark whether the registrant is a shell company (as defined in Rule\~12b-2 of the Exchange\plain\cf1\f51\fs20\ql Act).\~\plain\cf1\f54\fs20\ql o\plain\cf1\f51\fs20\ql \~\~Yes\~\~\~\plain\cf1\f54\fs20\ql x\plain\cf1\f51\fs20\ql \~\~No\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi264\cf1\f51\fs20\ql APPLICABLE ONLY TO ISSUERS INVOLVED IN BANKRUPTCY PROCEEDINGS DURING THE PRECEDING FIVE\plain\cf1\f51\fs20\ql YEARS:\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\ql Indicate by check mark whether the registrant has filed all documents and reports required to be filed by Section\~12, 13 or\plain\cf1\f51\fs20\ql 15(d)\~of the Securities Exchange Act of 1934 subsequent to the distribution of securities under a plan confirmed by a\plain\cf1\f51\fs20\ql court.\~\~\~\~Yes\~\~\plain\cf1\f54\fs20\ql o\plain\cf1\f51\fs20\ql \~\~\~No\~\plain\cf1\f54\fs20\ql o\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\qc APPLICABLE ONLY TO CORPORATE ISSUERS\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\ql As of May\~10, 2019 there were 22,949,064 shares of the registrant\u8217?s common stock, par value $0.001 per share,\plain\cf1\f51\fs20\ql outstanding.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\brdrb\brdrs\cf1\f51\fs2\ql \~\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par
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\page\pard\plain\ul{\field{\*\fldinst HYPERLINK \\l "tableofcontents_12906402" }{\*\fldrslt\cf3\f51\fs20\ql Table of Contents}}\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\qc SPECIAL NOTE REGARDING FORWARD-LOOKING STATEMENTS AND INDUSTRY DATA\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi748\cf1\f51\fs20\ql This Quarterly Report on Form\~10-Q (this \u8220?Quarterly Report\u8221?) contains forward-looking statements within\plain\cf1\f51\fs20\ql the meaning of Section\~27A of the Securities Act of 1933 and Section\~21E of the Securities Exchange Act of 1934, which reflect\plain\cf1\f51\fs20\ql our current views with respect to, among other things, our operations and financial performance. In some cases, you can identify\plain\cf1\f51\fs20\ql forward-looking statements by terminology such as \u8220?anticipate,\u8221? \u8220?believe,\u8221? \u8220?estimate,\u8221?\plain\cf1\f51\fs20\ql \u8220?expect,\u8221? \u8220?intend,\u8221? \u8220?may,\u8221? \u8220?plan,\u8221? \u8220?predict,\u8221?\plain\cf1\f51\fs20\ql \u8220?project,\u8221? \u8220?will\u8221? or the negative of such terms or other comparable terminology. Forward-looking\plain\cf1\f51\fs20\ql statements appear in a number of places throughout this Quarterly Report and include statements regarding our intentions, beliefs,\plain\cf1\f51\fs20\ql projections, outlook, analyses or current expectations concerning, among other things, our ability and plan to develop and\plain\cf1\f51\fs20\ql commercialize DKN-01 and TRX518; status, timing and results of preclinical studies and clinical trials; the potential benefits of\plain\cf1\f51\fs20\ql DKN-01 and TRX518; the timing of our development programs and seeking regulatory approval of DKN-01 and TRX518; our\plain\cf1\f51\fs20\ql ability to obtain and maintain regulatory approval; our estimates of expenses and future revenues and profitability; our estimates\plain\cf1\f51\fs20\ql regarding our capital requirements and our needs for additional financing; our estimates of the size of the potential markets for\plain\cf1\f51\fs20\ql DKN-01 and TRX518; our ability to attract collaborators with acceptable development, regulatory and commercial expertise; the\plain\cf1\f51\fs20\ql benefits to be derived from any collaborations, license agreements, and other acquisition efforts, including those relating to the\plain\cf1\f51\fs20\ql development and commercialization of DKN-01 and TRX518; sources of revenues and anticipated revenues, including\plain\cf1\f51\fs20\ql contributions from any collaborations or license agreements for the development and commercialization of products; our ability to\plain\cf1\f51\fs20\ql create an effective sales and marketing infrastructure if we elect to market and sell DKN-01 and TRX518 directly; the rate and\plain\cf1\f51\fs20\ql degree of market acceptance of DKN-01 and TRX518; the timing and amount or reimbursement for DKN-01 and TRX518; the\plain\cf1\f51\fs20\ql success of other competing therapies that may become available; the manufacturing capacity for DKN-01 and TRX518; our\plain\cf1\f51\fs20\ql intellectual property position; our ability to maintain and protect our intellectual property rights; our results of operations,\plain\cf1\f51\fs20\ql financial condition, liquidity, prospects, growth and strategies; the industry in which we operate; and the trends that may affect\plain\cf1\f51\fs20\ql the industry or us.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi748\cf1\f51\fs20\ql By their nature, forward-looking statements involve risks and uncertainties because they relate to events, competitive\plain\cf1\f51\fs20\ql dynamics and industry change, and depend on the economic circumstances that may or may not occur in the future or may occur\plain\cf1\f51\fs20\ql on longer or shorter timelines than anticipated. Although we believe that we have a reasonable basis for each forward-looking\plain\cf1\f51\fs20\ql statement contained in this Quarterly Report, we caution you that forward-looking statements are not guarantees of future\plain\cf1\f51\fs20\ql performance and that our actual results of operations, financial condition and liquidity, and the development of the industry in\plain\cf1\f51\fs20\ql which we operate may differ materially from the forward-looking statements contained in this Quarterly Report. In addition, even\plain\cf1\f51\fs20\ql if our results of operations, financial condition and liquidity, and events in the industry in which we operate are consistent with\plain\cf1\f51\fs20\ql the forward-looking statements contained in this Quarterly Report, they may not be predictive of results or developments in\plain\cf1\f51\fs20\ql future periods. You should carefully read this Quarterly Report and the documents that we have filed as exhibits to this Quarterly\plain\cf1\f51\fs20\ql Report completely.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi748\cf1\f51\fs20\ql You should refer to Part\~II,\~Item\~1A, Risk Factors in this Quarterly Report and Part\~I,\~Item IA, Risk Factors in our\plain\cf1\f51\fs20\ql Annual Report on Form\~10-K for the year ended December\~31, 2018 as filed with the Securities and Exchange Commission on\plain\cf1\f51\fs20\ql April\~1, 2019 for a discussion of important factors that may cause our actual results to differ materially from those expressed or\plain\cf1\f51\fs20\ql implied by our forward-looking statements. As a result of these factors, we cannot assure you that the forward-looking\plain\cf1\f51\fs20\ql statements in this Quarterly Report will prove to be accurate. Furthermore, if our forward-looking statements prove to be\plain\cf1\f51\fs20\ql inaccurate, the inaccuracy may be material. In light of the significant uncertainties in these forward-looking statements, you\plain\cf1\f51\fs20\ql should not regard these statements as a representation or warranty by us or any other person that we will achieve our objectives\plain\cf1\f51\fs20\ql and plans in any specified timeframe, or at all. Any forward-looking statements that we make in this Quarterly Report speaks\plain\cf1\f51\fs20\ql only as of the date of such statement, and, except to the extent required by applicable law, we undertake no obligation to update\plain\cf1\f51\fs20\ql such statements to reflect events or circumstances after the date of this Quarterly Report or to reflect the occurrence of\plain\cf1\f51\fs20\ql unanticipated events. You should, therefore, not rely on these forward-looking statements as representing our views as of any\plain\cf1\f51\fs20\ql date subsequent to the date of this Quarterly Report. Comparisons of results for current and any prior periods are not intended to\plain\cf1\f51\fs20\ql express any future trends or indications of future performance, unless expressed as such, and should only be viewed as historical\plain\cf1\f51\fs20\ql data.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi616\cf1\f51\fs20\ql DKN-01 and TRX518 are investigational drugs undergoing clinical development and have not been approved by the U.S.\plain\cf1\f51\fs20\ql Food and Drug Administration (the \u8220?FDA\u8221?), nor been submitted to the FDA for approval. DKN-01 and TRX518\plain\cf1\f51\fs20\ql have not been, and may never be, approved by any regulatory agency or marketed anywhere in the world. Statements contained\plain\cf1\f51\fs20\ql in this Quarterly Report should not be deemed to be promotional.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\qc 3{\*\bkmkstart pb_3_015910_7056_12906402}{\*\bkmkend pb_3_015910_7056_12906402}\par\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par
\page\pard\plain\ul{\field{\*\fldinst HYPERLINK \\l "tableofcontents_12906402" }{\*\fldrslt\cf3\f51\fs20\ql Table of Contents}}\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\qc INTRODUCTORY COMMENT\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\li330\fi-330\cf1\f51\fs20\b\ql References to Leap\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi616\cf1\f51\fs20\ql Throughout this Quarterly Report on Form\~10-Q, the \u8220?Company,\u8221? \u8220?Leap,\u8221? \u8220?Leap\plain\cf1\f51\fs20\ql Therapeutics,\u8221? \u8220?we,\u8221? \u8220?us,\u8221? and \u8220?our,\u8221? except where the context requires otherwise,\plain\cf1\f51\fs20\ql refer to Leap Therapeutics,\~Inc. and its consolidated subsidiaries, and \u8220?our board of directors\u8221? refers to the board of\plain\cf1\f51\fs20\ql directors of Leap Therapeutics,\~Inc.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\qc 4{\*\bkmkstart pb_4_015936_5335_12906402}{\*\bkmkend pb_4_015936_5335_12906402}\par\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par
\page\pard\plain\ul{\field{\*\fldinst HYPERLINK \\l "tableofcontents_12906402" }{\*\fldrslt\cf3\f51\fs20\ql Table of Contents}}\par\pard\plain\cf1\f51\fs20\ql \~{\*\bkmkstart part_1_2_1}{\*\bkmkend part_1_2_1}\par\pard\plain\cf1\f51\fs20\b\qc Part\~I \u8212? FINANCIAL INFORMATION{\*\bkmkstart partifinancialinformation_020114}{\*\bkmkend partifinancialinformation_020114}\par\pard\plain\cf1\f51\fs20\ql \~{\*\bkmkstart item_1_3_1}{\*\bkmkend item_1_3_1}\par\pard\plain\cf1\f51\fs20\b\ql Item 1. Financial Statements{\*\bkmkstart item1_financialstatements_020118}{\*\bkmkend item1_financialstatements_020118}\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\qc LEAP THERAPEUTICS,\~INC.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\qc CONDENSED CONSOLIDATED BALANCE SHEETS\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\qc (In thousands, except share and per share amounts)\par\pard\plain\cf1\f51\fs20\ql \~
\par\pard\plain
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\pard\plain\intbl\li440\fi-220\cf1\f51\fs20\ql Prepaid expenses and other current assets\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 159\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 202\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx7377\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7573\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9007\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9205\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10692\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10800\trrh248\row}}}
{\trowd\cellx7377\clvertalb\cellx7573\clvertalb\cellx9007\clvertalb\cellx9205\clvertalb\cellx10692\clvertalb\cellx10800\trrh248
\pard\plain\intbl\li660\fi-220\cf1\f51\fs20\ql Total current assets\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 22,712\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 17,322\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\cellx7377\clvertalb\cellx7573\clvertalb\cellx9007\clvertalb\cellx9205\clvertalb\cellx10692\clvertalb\cellx10800\trrh248\row}}}
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx7377\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7573\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9007\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9205\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10692\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10800\trrh248
\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell{
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx7377\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7573\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9007\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9205\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10692\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10800\trrh248\row}}}
{\trowd\cellx7377\clvertalb\cellx7573\clvertalb\cellx9007\clvertalb\cellx9205\clvertalb\cellx10692\clvertalb\cellx10800\trrh248
\pard\plain\intbl\li440\fi-220\cf1\f51\fs20\ql Property and equipment, net\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 74\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 86\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\cellx7377\clvertalb\cellx7573\clvertalb\cellx9007\clvertalb\cellx9205\clvertalb\cellx10692\clvertalb\cellx10800\trrh248\row}}}
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx7377\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7573\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9007\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9205\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10692\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10800\trrh248
\pard\plain\intbl\li440\fi-220\cf1\f51\fs20\ql Right of use asset, net\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 1,578\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \u8212?\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx7377\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7573\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9007\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9205\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10692\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10800\trrh248\row}}}
{\trowd\cellx7377\clvertalb\cellx7573\clvertalb\cellx9007\clvertalb\cellx9205\clvertalb\cellx10692\clvertalb\cellx10800\trrh248
\pard\plain\intbl\li440\fi-220\cf1\f51\fs20\ql Research and development incentive receivable, net of current portion\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 74\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \u8212?\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\cellx7377\clvertalb\cellx7573\clvertalb\cellx9007\clvertalb\cellx9205\clvertalb\cellx10692\clvertalb\cellx10800\trrh248\row}}}
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx7377\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7573\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9007\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9205\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10692\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10800\trrh248
\pard\plain\intbl\li440\fi-220\cf1\f51\fs20\ql Deferred tax assets\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 126\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 124\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx7377\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7573\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9007\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9205\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10692\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10800\trrh248\row}}}
{\trowd\cellx7377\clvertalb\cellx7573\clbrdrb\brdrs\brdrcf1\clvertalb\cellx9007\clvertalb\cellx9205\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10692\clvertalb\cellx10800\trrh248
\pard\plain\intbl\li440\fi-220\cf1\f51\fs20\ql Other assets\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 1,519\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 1,542\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\cellx7377\clvertalb\cellx7573\clbrdrb\brdrs\brdrcf1\clvertalb\cellx9007\clvertalb\cellx9205\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10692\clvertalb\cellx10800\trrh248\row}}}
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx7377\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7573\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7996\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9007\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9205\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9681\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10692\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10800\trrh248
\pard\plain\intbl\li660\fi-220\cf1\f51\fs20\ql Total assets\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr 26,083\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr 19,074\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx7377\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7573\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7996\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9007\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9205\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9681\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10692\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10800\trrh248\row}}}
{\trowd\cellx7377\clvertalb\cellx7573\clvertalb\cellx9007\clvertalb\cellx9205\clvertalb\cellx10692\clvertalb\cellx10800\trrh248
\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\b\ql Liabilities and Stockholders\u8217? Equity\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\qr \~\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\qr \~\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\cellx7377\clvertalb\cellx7573\clvertalb\cellx9007\clvertalb\cellx9205\clvertalb\cellx10692\clvertalb\cellx10800\trrh248\row}}}
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx7377\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7573\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9007\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9205\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10692\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10800\trrh248
\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\ql Current liabilities:\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\qr \~\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\qr \~\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx7377\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7573\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9007\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9205\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10692\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10800\trrh248\row}}}
{\trowd\cellx7377\clvertalb\cellx7573\clvertalb\cellx7996\clvertalb\cellx9007\clvertalb\cellx9205\clvertalb\cellx9681\clvertalb\cellx10692\clvertalb\cellx10800\trrh248
\pard\plain\intbl\li440\fi-220\cf1\f51\fs20\ql Accounts payable\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr 3,298\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr 3,579\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\cellx7377\clvertalb\cellx7573\clvertalb\cellx7996\clvertalb\cellx9007\clvertalb\cellx9205\clvertalb\cellx9681\clvertalb\cellx10692\clvertalb\cellx10800\trrh248\row}}}
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx7377\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7573\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9007\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9205\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10692\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10800\trrh248
\pard\plain\intbl\li440\fi-220\cf1\f51\fs20\ql Accrued expenses\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 4,150\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 2,872\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx7377\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7573\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9007\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9205\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10692\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10800\trrh248\row}}}
{\trowd\cellx7377\clvertalb\cellx7573\clbrdrb\brdrs\brdrcf1\clvertalb\cellx9007\clvertalb\cellx9205\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10692\clvertalb\cellx10800\trrh248
\pard\plain\intbl\li440\fi-220\cf1\f51\fs20\ql Lease liability - current portion\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 738\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \u8212?\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\cellx7377\clvertalb\cellx7573\clbrdrb\brdrs\brdrcf1\clvertalb\cellx9007\clvertalb\cellx9205\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10692\clvertalb\cellx10800\trrh248\row}}}
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx7377\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7573\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9007\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9205\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10692\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10800\trrh248
\pard\plain\intbl\li660\fi-220\cf1\f51\fs20\ql Total current liabilities\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 8,186\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 6,451\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx7377\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7573\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9007\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9205\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10692\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10800\trrh248\row}}}
{\trowd\cellx7377\clvertalb\cellx7573\clvertalb\cellx9007\clvertalb\cellx9205\clvertalb\cellx10692\clvertalb\cellx10800\trrh248
\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell{
{\trowd\cellx7377\clvertalb\cellx7573\clvertalb\cellx9007\clvertalb\cellx9205\clvertalb\cellx10692\clvertalb\cellx10800\trrh248\row}}}
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx7377\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7573\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9007\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9205\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10692\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10800\trrh248
\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\ql Non current liabilities:\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\qr \~\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\qr \~\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx7377\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7573\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9007\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9205\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10692\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10800\trrh248\row}}}
{\trowd\cellx7377\clvertalb\cellx7573\clvertalb\cellx9007\clvertalb\cellx9205\clvertalb\cellx10692\clvertalb\cellx10800\trrh248
\pard\plain\intbl\li440\fi-220\cf1\f51\fs20\ql Warrant liability\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \u8212?\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 3,448\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\cellx7377\clvertalb\cellx7573\clvertalb\cellx9007\clvertalb\cellx9205\clvertalb\cellx10692\clvertalb\cellx10800\trrh248\row}}}
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx7377\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7573\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9007\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9205\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10692\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10800\trrh248
\pard\plain\intbl\li440\fi-220\cf1\f51\fs20\ql Lease liability, net of current portion\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 833\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \u8212?\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx7377\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7573\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9007\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9205\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10692\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10800\trrh248\row}}}
{\trowd\cellx7377\clvertalb\cellx7573\clbrdrb\brdrs\brdrcf1\clvertalb\cellx9007\clvertalb\cellx9205\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10692\clvertalb\cellx10800\trrh248
\pard\plain\intbl\li660\fi-220\cf1\f51\fs20\ql Total liabilities\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 9,019\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 9,899\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\cellx7377\clvertalb\cellx7573\clbrdrb\brdrs\brdrcf1\clvertalb\cellx9007\clvertalb\cellx9205\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10692\clvertalb\cellx10800\trrh248\row}}}
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx7377\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7573\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9007\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9205\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10692\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10800\trrh248
\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\ql Commitments and contingencies (Note 9)\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\qr \~\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\qr \~\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx7377\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7573\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9007\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9205\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10692\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10800\trrh248\row}}}
{\trowd\cellx7377\clvertalb\cellx7573\clvertalb\cellx9007\clvertalb\cellx9205\clvertalb\cellx10692\clvertalb\cellx10800\trrh248
\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell{
{\trowd\cellx7377\clvertalb\cellx7573\clvertalb\cellx9007\clvertalb\cellx9205\clvertalb\cellx10692\clvertalb\cellx10800\trrh248\row}}}
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx7377\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7573\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9007\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9205\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10692\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10800\trrh248
\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\ql Stockholders\u8217? equity:\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\qr \~\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\qr \~\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx7377\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7573\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9007\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9205\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10692\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10800\trrh248\row}}}
{\trowd\cellx7377\clvertalb\cellx7573\clvertalb\cellx9007\clvertalb\cellx9205\clvertalb\cellx10692\clvertalb\cellx10800\trrh743
\pard\plain\intbl\li440\fi-220\cf1\f51\fs20\ql Common stock, $0.001 par value; 100,000,000 shares authorized as of March\~31,\plain\intbl\li440\cf1\f51\fs20\ql 2019 and December\~31, 2018, 22,260,301 and 14,703,159 shares issued and\plain\intbl\li440\cf1\f51\fs20\ql outstanding as of March\~31, 2019 and December\~31, 2018, respectively\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 22\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 15\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\cellx7377\clvertalb\cellx7573\clvertalb\cellx9007\clvertalb\cellx9205\clvertalb\cellx10692\clvertalb\cellx10800\trrh743\row}}}
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx7377\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7573\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9007\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9205\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10692\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10800\trrh248
\pard\plain\intbl\li440\fi-220\cf1\f51\fs20\ql Additional paid-in capital\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 187,635\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 162,393\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx7377\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7573\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9007\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9205\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10692\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10800\trrh248\row}}}
{\trowd\cellx7377\clvertalb\cellx7573\clvertalb\cellx9007\clvertalb\cellx9205\clvertalb\cellx10692\clvertalb\cellx10800\trrh248
\pard\plain\intbl\li440\fi-220\cf1\f51\fs20\ql Accumulated other comprehensive income\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 278\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 302\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\cellx7377\clvertalb\cellx7573\clvertalb\cellx9007\clvertalb\cellx9205\clvertalb\cellx10692\clvertalb\cellx10800\trrh248\row}}}
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx7377\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7573\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9007\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9205\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10692\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10800\trrh248
\pard\plain\intbl\li440\fi-220\cf1\f51\fs20\ql Accumulated deficit\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr (170,871\cell\pard\plain\intbl\cf1\f51\fs20\ql )\cell\pard\plain\intbl\cf1\f51\fs20\qr (153,535\cell\pard\plain\intbl\cf1\f51\fs20\ql )\cell{
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx7377\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7573\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9007\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9205\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10692\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10800\trrh248\row}}}
{\trowd\cellx7377\clvertalb\cellx7573\clbrdrb\brdrs\brdrcf1\clvertalb\cellx9007\clvertalb\cellx9205\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10692\clvertalb\cellx10800\trrh248
\pard\plain\intbl\li660\fi-220\cf1\f51\fs20\ql Total stockholders\u8217? equity\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 17,064\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 9,175\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\cellx7377\clvertalb\cellx7573\clbrdrb\brdrs\brdrcf1\clvertalb\cellx9007\clvertalb\cellx9205\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10692\clvertalb\cellx10800\trrh248\row}}}
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx7377\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7573\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7996\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9007\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9205\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9681\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10692\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10800\trrh248
\pard\plain\intbl\li660\fi-220\cf1\f51\fs20\ql Total liabilities and stockholders\u8217? equity\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr 26,083\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr 19,074\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx7377\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7573\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7996\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9007\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9205\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9681\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10692\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10800\trrh248\row}}}\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\qc See notes to condensed consolidated financial statements.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\qc 5{\*\bkmkstart pb_5_020840_6105_12906402}{\*\bkmkend pb_5_020840_6105_12906402}\par\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par
\page\pard\plain\ul{\field{\*\fldinst HYPERLINK \\l "tableofcontents_12906402" }{\*\fldrslt\cf3\f51\fs20\ql Table of Contents}}\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\qc LEAP THERAPEUTICS,\~INC.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\qc CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\qc (In thousands, except share and per share amounts)\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\qc (Unaudited)\par\pard\plain\cf1\f51\fs20\ql \~
\par\pard\plain
{\trowd\clvertalb\cellx7157\clvertalb\cellx7350\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10694\clvertalb\cellx10800\trrh198
\pard\plain\intbl\cf1\f51\fs2\b\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs16\b\qc Three\~Months\~Ended\~March\~31,\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell{
{\trowd\clvertalb\cellx7157\clvertalb\cellx7350\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10694\clvertalb\cellx10800\trrh198\row}}}
{\trowd\clvertalb\cellx7157\clvertalb\cellx7350\clbrdrb\brdrs\brdrcf1\clvertalb\cellx8790\clvertalb\cellx9234\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10694\clvertalb\cellx10800\trrh198
\pard\plain\intbl\cf1\f51\fs2\b\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs16\b\qc 2019\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs16\b\qc 2018\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell{
{\trowd\clvertalb\cellx7157\clvertalb\cellx7350\clbrdrb\brdrs\brdrcf1\clvertalb\cellx8790\clvertalb\cellx9234\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10694\clvertalb\cellx10800\trrh198\row}}}
{\trowd\cellx7157\clvertalb\cellx7350\clvertalb\cellx8790\clvertalb\cellx9234\clvertalb\cellx10694\clvertalb\cellx10800\trrh248
\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell{
{\trowd\cellx7157\clvertalb\cellx7350\clvertalb\cellx8790\clvertalb\cellx9234\clvertalb\cellx10694\clvertalb\cellx10800\trrh248\row}}}
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx7157\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7350\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8790\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9234\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10694\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10800\trrh248
\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\ql Operating expenses:\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\qr \~\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\qr \~\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx7157\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7350\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8790\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9234\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10694\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10800\trrh248\row}}}
{\trowd\cellx7157\clvertalb\cellx7350\clvertalb\cellx7794\clvertalb\cellx8790\clvertalb\cellx9234\clvertalb\cellx9678\clvertalb\cellx10694\clvertalb\cellx10800\trrh248
\pard\plain\intbl\li440\fi-220\cf1\f51\fs20\ql Research and development\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr 6,790\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr 4,231\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\cellx7157\clvertalb\cellx7350\clvertalb\cellx7794\clvertalb\cellx8790\clvertalb\cellx9234\clvertalb\cellx9678\clvertalb\cellx10694\clvertalb\cellx10800\trrh248\row}}}
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx7157\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7350\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8790\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9234\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10694\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10800\trrh248
\pard\plain\intbl\li440\fi-220\cf1\f51\fs20\ql General and administrative\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 2,005\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 2,113\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx7157\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7350\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8790\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9234\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10694\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10800\trrh248\row}}}
{\trowd\cellx7157\clvertalb\cellx7350\clbrdrb\brdrs\brdrcf1\clvertalb\cellx8790\clvertalb\cellx9234\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10694\clvertalb\cellx10800\trrh248
\pard\plain\intbl\li660\fi-220\cf1\f51\fs20\ql Total operating expenses\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 8,795\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 6,344\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\cellx7157\clvertalb\cellx7350\clbrdrb\brdrs\brdrcf1\clvertalb\cellx8790\clvertalb\cellx9234\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10694\clvertalb\cellx10800\trrh248\row}}}
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx7157\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7350\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8790\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9234\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10694\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10800\trrh248
\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\ql Loss from operations\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr (8,795\cell\pard\plain\intbl\cf1\f51\fs20\ql )\cell\pard\plain\intbl\cf1\f51\fs20\qr (6,344\cell\pard\plain\intbl\cf1\f51\fs20\ql )\cell{
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx7157\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7350\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8790\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9234\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10694\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10800\trrh248\row}}}
{\trowd\cellx7157\clvertalb\cellx7350\clvertalb\cellx8790\clvertalb\cellx9234\clvertalb\cellx10694\clvertalb\cellx10800\trrh248
\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\ql Interest income\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 82\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 77\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\cellx7157\clvertalb\cellx7350\clvertalb\cellx8790\clvertalb\cellx9234\clvertalb\cellx10694\clvertalb\cellx10800\trrh248\row}}}
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx7157\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7350\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8790\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9234\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10694\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10800\trrh248
\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\ql Interest expense\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr (7\cell\pard\plain\intbl\cf1\f51\fs20\ql )\cell\pard\plain\intbl\cf1\f51\fs20\qr (6\cell\pard\plain\intbl\cf1\f51\fs20\ql )\cell{
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx7157\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7350\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8790\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9234\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10694\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10800\trrh248\row}}}
{\trowd\cellx7157\clvertalb\cellx7350\clvertalb\cellx8790\clvertalb\cellx9234\clvertalb\cellx10694\clvertalb\cellx10800\trrh248
\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\ql Australian research and development incentives\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 75\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 646\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\cellx7157\clvertalb\cellx7350\clvertalb\cellx8790\clvertalb\cellx9234\clvertalb\cellx10694\clvertalb\cellx10800\trrh248\row}}}
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx7157\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7350\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8790\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9234\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10694\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10800\trrh248
\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\ql Foreign currency gains (loss)\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 42\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr (144\cell\pard\plain\intbl\cf1\f51\fs20\ql )\cell{
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx7157\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7350\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8790\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9234\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10694\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10800\trrh248\row}}}
{\trowd\cellx7157\clvertalb\cellx7350\clbrdrb\brdrs\brdrcf1\clvertalb\cellx8790\clvertalb\cellx9234\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10694\clvertalb\cellx10800\trrh248
\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\ql Change in fair value of warrant liability\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \u8212?\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr (4,851\cell\pard\plain\intbl\cf1\f51\fs20\ql )\cell{
{\trowd\cellx7157\clvertalb\cellx7350\clbrdrb\brdrs\brdrcf1\clvertalb\cellx8790\clvertalb\cellx9234\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10694\clvertalb\cellx10800\trrh248\row}}}
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx7157\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7350\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7794\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8790\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9234\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9678\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10694\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10800\trrh248
\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\ql Net loss\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr (8,603\cell\pard\plain\intbl\cf1\f51\fs20\ql )\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr (10,622\cell\pard\plain\intbl\cf1\f51\fs20\ql )\cell{
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx7157\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7350\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7794\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8790\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9234\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9678\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10694\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10800\trrh248\row}}}
{\trowd\cellx7157\clvertalb\cellx7350\clbrdrb\brdrs\brdrcf1\clvertalb\cellx7794\clbrdrb\brdrs\brdrcf1\clvertalb\cellx8790\clvertalb\cellx9234\clbrdrb\brdrs\brdrcf1\clvertalb\cellx9678\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10694\clvertalb\cellx10800\trrh248
\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\ql Dividend attributable to down round feature of warrants\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr (359\cell\pard\plain\intbl\cf1\f51\fs20\ql )\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \u8212?\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\cellx7157\clvertalb\cellx7350\clbrdrb\brdrs\brdrcf1\clvertalb\cellx7794\clbrdrb\brdrs\brdrcf1\clvertalb\cellx8790\clvertalb\cellx9234\clbrdrb\brdrs\brdrcf1\clvertalb\cellx9678\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10694\clvertalb\cellx10800\trrh248\row}}}
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx7157\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7350\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7794\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8790\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9234\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9678\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10694\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10800\trrh248
\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\ql Net loss attributable to common stockholders\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr (8,962\cell\pard\plain\intbl\cf1\f51\fs20\ql )\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr (10,622\cell\pard\plain\intbl\cf1\f51\fs20\ql )\cell{
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx7157\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7350\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7794\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8790\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9234\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9678\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10694\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10800\trrh248\row}}}
{\trowd\cellx7157\clvertalb\cellx7350\clvertalb\cellx8790\clvertalb\cellx9234\clvertalb\cellx10694\clvertalb\cellx10800\trrh248
\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell{
{\trowd\cellx7157\clvertalb\cellx7350\clvertalb\cellx8790\clvertalb\cellx9234\clvertalb\cellx10694\clvertalb\cellx10800\trrh248\row}}}
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx7157\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7350\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7794\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8790\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9234\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9678\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10694\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10800\trrh248
\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\ql Net loss per share - basic and diluted\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr (0.47\cell\pard\plain\intbl\cf1\f51\fs20\ql )\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr (0.85\cell\pard\plain\intbl\cf1\f51\fs20\ql )\cell{
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx7157\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7350\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7794\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8790\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9234\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9678\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10694\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10800\trrh248\row}}}
{\trowd\cellx7157\clvertalb\cellx7350\clvertalb\cellx8790\clvertalb\cellx9234\clvertalb\cellx10694\clvertalb\cellx10800\trrh248
\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell{
{\trowd\cellx7157\clvertalb\cellx7350\clvertalb\cellx8790\clvertalb\cellx9234\clvertalb\cellx10694\clvertalb\cellx10800\trrh248\row}}}
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx7157\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7350\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8790\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9234\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10694\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10800\trrh248
\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\ql Weighted average common shares outstanding - basic and diluted\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 19,237,444\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 12,449,421\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx7157\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7350\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8790\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9234\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10694\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10800\trrh248\row}}}\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\qc See notes to condensed consolidated financial statements.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\qc 6{\*\bkmkstart pb_6_021013_7056_12906402}{\*\bkmkend pb_6_021013_7056_12906402}\par\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par
\page\pard\plain\ul{\field{\*\fldinst HYPERLINK \\l "tableofcontents_12906402" }{\*\fldrslt\cf3\f51\fs20\ql Table of Contents}}\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\qc LEAP THERAPEUTICS,\~INC.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\qc CONDENSED CONSOLIDATED STATEMENTS OF COMPREHENSIVE LOSS\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\qc (In thousands)\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\qc (Unaudited)\par\pard\plain\cf1\f51\fs20\ql \~
\par\pard\plain
{\trowd\clvertalb\cellx7131\clvertalb\cellx7328\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10693\clvertalb\cellx10800\trrh198
\pard\plain\intbl\cf1\f51\fs2\b\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs16\b\qc Three\~Months\~Ended\~March\~31,\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell{
{\trowd\clvertalb\cellx7131\clvertalb\cellx7328\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10693\clvertalb\cellx10800\trrh198\row}}}
{\trowd\clvertalb\cellx7131\clvertalb\cellx7328\clbrdrb\brdrs\brdrcf1\clvertalb\cellx8782\clvertalb\cellx9226\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10693\clvertalb\cellx10800\trrh198
\pard\plain\intbl\cf1\f51\fs2\b\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs16\b\qc 2019\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs16\b\qc 2018\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell{
{\trowd\clvertalb\cellx7131\clvertalb\cellx7328\clbrdrb\brdrs\brdrcf1\clvertalb\cellx8782\clvertalb\cellx9226\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10693\clvertalb\cellx10800\trrh198\row}}}
{\trowd\cellx7131\clvertalb\cellx7328\clvertalb\cellx8782\clvertalb\cellx9226\clvertalb\cellx10693\clvertalb\cellx10800\trrh248
\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell{
{\trowd\cellx7131\clvertalb\cellx7328\clvertalb\cellx8782\clvertalb\cellx9226\clvertalb\cellx10693\clvertalb\cellx10800\trrh248\row}}}
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx7131\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7328\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7772\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8782\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9226\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9670\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10693\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10800\trrh248
\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\ql Net loss\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr (8,603\cell\pard\plain\intbl\cf1\f51\fs20\ql )\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr (10,622\cell\pard\plain\intbl\cf1\f51\fs20\ql )\cell{
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx7131\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7328\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7772\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8782\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9226\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9670\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10693\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10800\trrh248\row}}}
{\trowd\cellx7131\clvertalb\cellx7328\clvertalb\cellx8782\clvertalb\cellx9226\clvertalb\cellx10693\clvertalb\cellx10800\trrh248
\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell{
{\trowd\cellx7131\clvertalb\cellx7328\clvertalb\cellx8782\clvertalb\cellx9226\clvertalb\cellx10693\clvertalb\cellx10800\trrh248\row}}}
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx7131\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7328\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8782\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9226\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10693\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10800\trrh248
\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\ql Other comprehensive loss:\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\qr \~\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\qr \~\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx7131\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7328\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8782\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9226\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10693\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10800\trrh248\row}}}
{\trowd\cellx7131\clvertalb\cellx7328\clbrdrb\brdrs\brdrcf1\clvertalb\cellx8782\clvertalb\cellx9226\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10693\clvertalb\cellx10800\trrh248
\pard\plain\intbl\li440\fi-220\cf1\f51\fs20\ql Foreign currency translation adjustments\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr (24\cell\pard\plain\intbl\cf1\f51\fs20\ql )\cell\pard\plain\intbl\cf1\f51\fs20\qr 110\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\cellx7131\clvertalb\cellx7328\clbrdrb\brdrs\brdrcf1\clvertalb\cellx8782\clvertalb\cellx9226\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10693\clvertalb\cellx10800\trrh248\row}}}
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx7131\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7328\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7772\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8782\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9226\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9670\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10693\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10800\trrh248
\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\ql Comprehensive loss\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr (8,627\cell\pard\plain\intbl\cf1\f51\fs20\ql )\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr (10,512\cell\pard\plain\intbl\cf1\f51\fs20\ql )\cell{
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx7131\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7328\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7772\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8782\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9226\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9670\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10693\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10800\trrh248\row}}}\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\qc See notes to condensed consolidated financial statements.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\qc 7{\*\bkmkstart pb_7_021059_5335_12906402}{\*\bkmkend pb_7_021059_5335_12906402}\par\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par
\page\pard\plain\ul{\field{\*\fldinst HYPERLINK \\l "tableofcontents_12906402" }{\*\fldrslt\cf3\f51\fs20\ql Table of Contents}}\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\qc LEAP THERAPEUTICS,\~INC.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\qc CONDENSED CONSOLIDATED STATEMENTS OF STOCKHOLDERS\u8217? EQUITY\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\qc (In thousands, except share amounts)\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\qc (Unaudited)\par\pard\plain\cf1\f51\fs20\ql \~
\par\pard\plain
{\trowd\clvertalb\cellx2681\clvertalb\cellx2773\clvertalb\cellx3693\clvertalb\cellx4050\clvertalb\cellx4832\clvertalb\cellx4924\clvertalb\cellx6083\clvertalb\cellx6239\clvertalb\cellx7579\clvertalb\cellx7742\clvertalb\cellx9017\clvertalb\cellx9180\clvertalb\cellx10707\clvertalb\cellx10800\trrh198
\pard\plain\intbl\cf1\f51\fs2\b\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs16\b\qc Accumulated\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell{
{\trowd\clvertalb\cellx2681\clvertalb\cellx2773\clvertalb\cellx3693\clvertalb\cellx4050\clvertalb\cellx4832\clvertalb\cellx4924\clvertalb\cellx6083\clvertalb\cellx6239\clvertalb\cellx7579\clvertalb\cellx7742\clvertalb\cellx9017\clvertalb\cellx9180\clvertalb\cellx10707\clvertalb\cellx10800\trrh198\row}}}
{\trowd\clvertalb\cellx2681\clvertalb\cellx2773\clvertalb\cellx3693\clvertalb\cellx4050\clvertalb\cellx4832\clvertalb\cellx4924\clvertalb\cellx6083\clvertalb\cellx6239\clvertalb\cellx7579\clvertalb\cellx7742\clvertalb\cellx9017\clvertalb\cellx9180\clvertalb\cellx10707\clvertalb\cellx10800\trrh198
\pard\plain\intbl\cf1\f51\fs2\b\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs16\b\qc Additional\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs16\b\qc Other\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs16\b\qc Total\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell{
{\trowd\clvertalb\cellx2681\clvertalb\cellx2773\clvertalb\cellx3693\clvertalb\cellx4050\clvertalb\cellx4832\clvertalb\cellx4924\clvertalb\cellx6083\clvertalb\cellx6239\clvertalb\cellx7579\clvertalb\cellx7742\clvertalb\cellx9017\clvertalb\cellx9180\clvertalb\cellx10707\clvertalb\cellx10800\trrh198\row}}}
{\trowd\clvertalb\cellx2681\clvertalb\cellx2773\clbrdrb\brdrs\brdrcf1\clvertalb\cellx4833\clvertalb\cellx4925\clvertalb\cellx6084\clvertalb\cellx6240\clvertalb\cellx7580\clvertalb\cellx7743\clvertalb\cellx9018\clvertalb\cellx9181\clvertalb\cellx10708\clvertalb\cellx10800\trrh198
\pard\plain\intbl\cf1\f51\fs2\b\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs16\b\qc Common\~Stock\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs16\b\qc Paid-in\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs16\b\qc Comprehensive\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs16\b\qc Accumulated\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs16\b\qc Stockholders\u8217?\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell{
{\trowd\clvertalb\cellx2681\clvertalb\cellx2773\clbrdrb\brdrs\brdrcf1\clvertalb\cellx4833\clvertalb\cellx4925\clvertalb\cellx6084\clvertalb\cellx6240\clvertalb\cellx7580\clvertalb\cellx7743\clvertalb\cellx9018\clvertalb\cellx9181\clvertalb\cellx10708\clvertalb\cellx10800\trrh198\row}}}
{\trowd\clvertalb\cellx2681\clvertalb\cellx2773\clbrdrb\brdrs\brdrcf1\clvertalb\cellx3693\clvertalb\cellx4050\clbrdrb\brdrs\brdrcf1\clvertalb\cellx4832\clvertalb\cellx4924\clbrdrb\brdrs\brdrcf1\clvertalb\cellx6083\clvertalb\cellx6239\clbrdrb\brdrs\brdrcf1\clvertalb\cellx7579\clvertalb\cellx7742\clbrdrb\brdrs\brdrcf1\clvertalb\cellx9017\clvertalb\cellx9180\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10707\clvertalb\cellx10800\trrh198
\pard\plain\intbl\cf1\f51\fs2\b\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs16\b\qc Shares\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs16\b\qc Amount\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs16\b\qc Capital\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs16\b\qc Loss\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs16\b\qc Deficit\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs16\b\qc Equity\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell{
{\trowd\clvertalb\cellx2681\clvertalb\cellx2773\clbrdrb\brdrs\brdrcf1\clvertalb\cellx3693\clvertalb\cellx4050\clbrdrb\brdrs\brdrcf1\clvertalb\cellx4832\clvertalb\cellx4924\clbrdrb\brdrs\brdrcf1\clvertalb\cellx6083\clvertalb\cellx6239\clbrdrb\brdrs\brdrcf1\clvertalb\cellx7579\clvertalb\cellx7742\clbrdrb\brdrs\brdrcf1\clvertalb\cellx9017\clvertalb\cellx9180\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10707\clvertalb\cellx10800\trrh198\row}}}
{\trowd\cellx2681\clvertalb\cellx2773\clvertalb\cellx3693\clvertalb\cellx4050\clvertalb\cellx4832\clvertalb\cellx4924\clvertalb\cellx6083\clvertalb\cellx6239\clvertalb\cellx7579\clvertalb\cellx7742\clvertalb\cellx9017\clvertalb\cellx9180\clvertalb\cellx10707\clvertalb\cellx10800\trrh248
\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell{
{\trowd\cellx2681\clvertalb\cellx2773\clvertalb\cellx3693\clvertalb\cellx4050\clvertalb\cellx4832\clvertalb\cellx4924\clvertalb\cellx6083\clvertalb\cellx6239\clvertalb\cellx7579\clvertalb\cellx7742\clvertalb\cellx9017\clvertalb\cellx9180\clvertalb\cellx10707\clvertalb\cellx10800\trrh248\row}}}
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx2681\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx2773\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx3693\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4050\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4832\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4924\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5298\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6083\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6239\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6782\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7579\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7742\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8205\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9017\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9180\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9901\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10706\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10800\trrh495
\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\b\ql Balances at December\~31,\plain\intbl\li220\cf1\f51\fs20\b\ql 2017\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 12,354,014\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 12\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr 141,770\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr (268\cell\pard\plain\intbl\cf1\f51\fs20\ql )\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr (130,397\cell\pard\plain\intbl\cf1\f51\fs20\ql )\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr 11,117\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx2681\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx2773\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx3693\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4050\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4832\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4924\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5298\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6083\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6239\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6782\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7579\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7742\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8205\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9017\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9180\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9901\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10706\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10800\trrh495\row}}}
{\trowd\cellx2681\clvertalb\cellx2773\clvertalb\cellx3693\clvertalb\cellx4050\clvertalb\cellx4832\clvertalb\cellx4924\clvertalb\cellx6083\clvertalb\cellx6239\clvertalb\cellx7579\clvertalb\cellx7742\clvertalb\cellx9017\clvertalb\cellx9180\clvertalb\cellx10707\clvertalb\cellx10800\trrh248
\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell{
{\trowd\cellx2681\clvertalb\cellx2773\clvertalb\cellx3693\clvertalb\cellx4050\clvertalb\cellx4832\clvertalb\cellx4924\clvertalb\cellx6083\clvertalb\cellx6239\clvertalb\cellx7579\clvertalb\cellx7742\clvertalb\cellx9017\clvertalb\cellx9180\clvertalb\cellx10707\clvertalb\cellx10800\trrh248\row}}}
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx2681\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx2773\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx3693\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4050\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4832\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4924\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6083\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6239\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7579\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7742\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9017\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9180\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10707\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10800\trrh990
\pard\plain\intbl\li440\fi-220\cf1\f51\fs20\ql Issuance of common stock in\plain\intbl\li440\cf1\f51\fs20\ql connection with Public\plain\intbl\li440\cf1\f51\fs20\ql Offering, net of issuance\plain\intbl\li440\cf1\f51\fs20\ql costs of $1,304\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 2,146,667\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 3\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 14,792\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \u8212?\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \u8212?\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 14,795\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx2681\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx2773\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx3693\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4050\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4832\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4924\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6083\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6239\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7579\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7742\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9017\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9180\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10707\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10800\trrh990\row}}}
{\trowd\cellx2681\clvertalb\cellx2773\clvertalb\cellx3693\clvertalb\cellx4050\clvertalb\cellx4832\clvertalb\cellx4924\clvertalb\cellx6083\clvertalb\cellx6239\clvertalb\cellx7579\clvertalb\cellx7742\clvertalb\cellx9017\clvertalb\cellx9180\clvertalb\cellx10707\clvertalb\cellx10800\trrh495
\pard\plain\intbl\li440\fi-220\cf1\f51\fs20\ql Foreign currency translation\plain\intbl\li440\cf1\f51\fs20\ql adjustment\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \u8212?\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \u8212?\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \u8212?\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 110\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \u8212?\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 110\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\cellx2681\clvertalb\cellx2773\clvertalb\cellx3693\clvertalb\cellx4050\clvertalb\cellx4832\clvertalb\cellx4924\clvertalb\cellx6083\clvertalb\cellx6239\clvertalb\cellx7579\clvertalb\cellx7742\clvertalb\cellx9017\clvertalb\cellx9180\clvertalb\cellx10707\clvertalb\cellx10800\trrh495\row}}}
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx2681\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx2773\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx3693\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4050\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4832\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4924\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6083\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6239\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7579\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7742\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9017\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9180\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10707\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10800\trrh248
\pard\plain\intbl\li440\fi-220\cf1\f51\fs20\ql Stock-based compensation\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \u8212?\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \u8212?\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 728\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \u8212?\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \u8212?\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 728\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx2681\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx2773\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx3693\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4050\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4832\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4924\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6083\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6239\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7579\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7742\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9017\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9180\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10707\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10800\trrh248\row}}}
{\trowd\cellx2681\clvertalb\cellx2773\clbrdrb\brdrs\brdrcf1\clvertalb\cellx3693\clvertalb\cellx4050\clbrdrb\brdrs\brdrcf1\clvertalb\cellx4832\clvertalb\cellx4924\clbrdrb\brdrs\brdrcf1\clvertalb\cellx6083\clvertalb\cellx6239\clbrdrb\brdrs\brdrcf1\clvertalb\cellx7579\clvertalb\cellx7742\clbrdrb\brdrs\brdrcf1\clvertalb\cellx9017\clvertalb\cellx9180\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10707\clvertalb\cellx10800\trrh248
\pard\plain\intbl\li440\fi-220\cf1\f51\fs20\ql Net loss\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \u8212?\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \u8212?\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \u8212?\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \u8212?\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr (10,622\cell\pard\plain\intbl\cf1\f51\fs20\ql )\cell\pard\plain\intbl\cf1\f51\fs20\qr (10,622\cell\pard\plain\intbl\cf1\f51\fs20\ql )\cell{
{\trowd\cellx2681\clvertalb\cellx2773\clbrdrb\brdrs\brdrcf1\clvertalb\cellx3693\clvertalb\cellx4050\clbrdrb\brdrs\brdrcf1\clvertalb\cellx4832\clvertalb\cellx4924\clbrdrb\brdrs\brdrcf1\clvertalb\cellx6083\clvertalb\cellx6239\clbrdrb\brdrs\brdrcf1\clvertalb\cellx7579\clvertalb\cellx7742\clbrdrb\brdrs\brdrcf1\clvertalb\cellx9017\clvertalb\cellx9180\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10707\clvertalb\cellx10800\trrh248\row}}}
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx2681\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx2773\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx3693\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4050\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4832\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4924\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5298\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6083\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6239\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6782\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7579\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7742\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8205\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9017\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9180\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9901\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10706\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10800\trrh248
\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\b\ql Balances at March\~31, 2018\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 14,500,681\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 15\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr 157,290\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr (158\cell\pard\plain\intbl\cf1\f51\fs20\ql )\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr (141,019\cell\pard\plain\intbl\cf1\f51\fs20\ql )\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr 16,128\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx2681\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx2773\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx3693\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4050\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4832\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4924\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5298\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6083\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6239\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6782\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7579\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7742\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8205\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9017\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9180\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9901\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10706\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10800\trrh248\row}}}\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\ql \~
\par\pard\plain
{\trowd\clvertalb\cellx2677\clvertalb\cellx2824\clvertalb\cellx3771\clvertalb\cellx4128\clvertalb\cellx4956\clvertalb\cellx5103\clvertalb\cellx6251\clvertalb\cellx6398\clvertalb\cellx7713\clvertalb\cellx7811\clvertalb\cellx9078\clvertalb\cellx9176\clvertalb\cellx10694\clvertalb\cellx10800\trrh198
\pard\plain\intbl\cf1\f51\fs2\b\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs16\b\qc Accumulated\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell{
{\trowd\clvertalb\cellx2677\clvertalb\cellx2824\clvertalb\cellx3771\clvertalb\cellx4128\clvertalb\cellx4956\clvertalb\cellx5103\clvertalb\cellx6251\clvertalb\cellx6398\clvertalb\cellx7713\clvertalb\cellx7811\clvertalb\cellx9078\clvertalb\cellx9176\clvertalb\cellx10694\clvertalb\cellx10800\trrh198\row}}}
{\trowd\clvertalb\cellx2677\clvertalb\cellx2824\clvertalb\cellx3771\clvertalb\cellx4128\clvertalb\cellx4956\clvertalb\cellx5103\clvertalb\cellx6251\clvertalb\cellx6398\clvertalb\cellx7713\clvertalb\cellx7811\clvertalb\cellx9078\clvertalb\cellx9176\clvertalb\cellx10694\clvertalb\cellx10800\trrh198
\pard\plain\intbl\cf1\f51\fs2\b\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs16\b\qc Additional\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs16\b\qc Other\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs16\b\qc Total\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell{
{\trowd\clvertalb\cellx2677\clvertalb\cellx2824\clvertalb\cellx3771\clvertalb\cellx4128\clvertalb\cellx4956\clvertalb\cellx5103\clvertalb\cellx6251\clvertalb\cellx6398\clvertalb\cellx7713\clvertalb\cellx7811\clvertalb\cellx9078\clvertalb\cellx9176\clvertalb\cellx10694\clvertalb\cellx10800\trrh198\row}}}
{\trowd\clvertalb\cellx2677\clvertalb\cellx2824\clbrdrb\brdrs\brdrcf1\clvertalb\cellx4958\clvertalb\cellx5105\clvertalb\cellx6253\clvertalb\cellx6400\clvertalb\cellx7715\clvertalb\cellx7813\clvertalb\cellx9080\clvertalb\cellx9178\clvertalb\cellx10696\clvertalb\cellx10800\trrh198
\pard\plain\intbl\cf1\f51\fs2\b\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs16\b\qc Common\~Stock\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs16\b\qc Paid-in\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs16\b\qc Comprehensive\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs16\b\qc Accumulated\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs16\b\qc Stockholders\u8217?\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell{
{\trowd\clvertalb\cellx2677\clvertalb\cellx2824\clbrdrb\brdrs\brdrcf1\clvertalb\cellx4958\clvertalb\cellx5105\clvertalb\cellx6253\clvertalb\cellx6400\clvertalb\cellx7715\clvertalb\cellx7813\clvertalb\cellx9080\clvertalb\cellx9178\clvertalb\cellx10696\clvertalb\cellx10800\trrh198\row}}}
{\trowd\clvertalb\cellx2677\clvertalb\cellx2824\clbrdrb\brdrs\brdrcf1\clvertalb\cellx3771\clvertalb\cellx4128\clbrdrb\brdrs\brdrcf1\clvertalb\cellx4956\clvertalb\cellx5103\clbrdrb\brdrs\brdrcf1\clvertalb\cellx6251\clvertalb\cellx6398\clbrdrb\brdrs\brdrcf1\clvertalb\cellx7713\clvertalb\cellx7811\clbrdrb\brdrs\brdrcf1\clvertalb\cellx9078\clvertalb\cellx9176\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10694\clvertalb\cellx10800\trrh198
\pard\plain\intbl\cf1\f51\fs2\b\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs16\b\qc Shares\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs16\b\qc Amount\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs16\b\qc Capital\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs16\b\qc Loss\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs16\b\qc Deficit\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs16\b\qc Equity\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell{
{\trowd\clvertalb\cellx2677\clvertalb\cellx2824\clbrdrb\brdrs\brdrcf1\clvertalb\cellx3771\clvertalb\cellx4128\clbrdrb\brdrs\brdrcf1\clvertalb\cellx4956\clvertalb\cellx5103\clbrdrb\brdrs\brdrcf1\clvertalb\cellx6251\clvertalb\cellx6398\clbrdrb\brdrs\brdrcf1\clvertalb\cellx7713\clvertalb\cellx7811\clbrdrb\brdrs\brdrcf1\clvertalb\cellx9078\clvertalb\cellx9176\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10694\clvertalb\cellx10800\trrh198\row}}}
{\trowd\cellx2677\clvertalb\cellx2824\clvertalb\cellx3771\clvertalb\cellx4128\clvertalb\cellx4956\clvertalb\cellx5103\clvertalb\cellx6251\clvertalb\cellx6398\clvertalb\cellx7713\clvertalb\cellx7811\clvertalb\cellx9078\clvertalb\cellx9176\clvertalb\cellx10694\clvertalb\cellx10800\trrh248
\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell{
{\trowd\cellx2677\clvertalb\cellx2824\clvertalb\cellx3771\clvertalb\cellx4128\clvertalb\cellx4956\clvertalb\cellx5103\clvertalb\cellx6251\clvertalb\cellx6398\clvertalb\cellx7713\clvertalb\cellx7811\clvertalb\cellx9078\clvertalb\cellx9176\clvertalb\cellx10694\clvertalb\cellx10800\trrh248\row}}}
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx2677\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx2824\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx3771\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4128\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4956\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5103\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5477\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6250\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6397\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6940\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7712\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7810\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8273\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9077\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9175\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9896\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10693\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10800\trrh495
\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\b\ql Balances at December\~31,\plain\intbl\li220\cf1\f51\fs20\b\ql 2018\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 14,703,159\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 15\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr 162,393\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr 302\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr (153,535\cell\pard\plain\intbl\cf1\f51\fs20\ql )\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr 9,175\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx2677\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx2824\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx3771\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4128\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4956\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5103\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5477\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6250\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6397\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6940\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7712\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7810\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8273\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9077\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9175\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9896\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10693\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10800\trrh495\row}}}
{\trowd\cellx2677\clvertalb\cellx2824\clvertalb\cellx3771\clvertalb\cellx4128\clvertalb\cellx4956\clvertalb\cellx5103\clvertalb\cellx5477\clvertalb\cellx6250\clvertalb\cellx6397\clvertalb\cellx6940\clvertalb\cellx7712\clvertalb\cellx7810\clvertalb\cellx8273\clvertalb\cellx9077\clvertalb\cellx9175\clvertalb\cellx9896\clvertalb\cellx10693\clvertalb\cellx10800\trrh248
\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\b\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell{
{\trowd\cellx2677\clvertalb\cellx2824\clvertalb\cellx3771\clvertalb\cellx4128\clvertalb\cellx4956\clvertalb\cellx5103\clvertalb\cellx5477\clvertalb\cellx6250\clvertalb\cellx6397\clvertalb\cellx6940\clvertalb\cellx7712\clvertalb\cellx7810\clvertalb\cellx8273\clvertalb\cellx9077\clvertalb\cellx9175\clvertalb\cellx9896\clvertalb\cellx10693\clvertalb\cellx10800\trrh248\row}}}
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx2677\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx2824\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx3771\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4128\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4956\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5103\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6251\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6398\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7713\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7811\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9078\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9176\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10694\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10800\trrh990
\pard\plain\intbl\li440\fi-220\cf1\f51\fs20\ql Reclassification of 2017\plain\intbl\li440\cf1\f51\fs20\ql Warrants from liability to\plain\intbl\li440\cf1\f51\fs20\ql equity upon adoption of\plain\intbl\li440\cf1\f51\fs20\ql ASU 2017-11\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \u8212?\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \u8212?\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 11,821\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \u8212?\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr (8,374\cell\pard\plain\intbl\cf1\f51\fs20\ql )\cell\pard\plain\intbl\cf1\f51\fs20\qr 3,447\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx2677\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx2824\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx3771\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4128\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4956\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5103\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6251\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6398\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7713\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7811\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9078\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9176\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10694\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10800\trrh990\row}}}
{\trowd\cellx2677\clvertalb\cellx2824\clvertalb\cellx3771\clvertalb\cellx4128\clvertalb\cellx4956\clvertalb\cellx5103\clvertalb\cellx6251\clvertalb\cellx6398\clvertalb\cellx7713\clvertalb\cellx7811\clvertalb\cellx9078\clvertalb\cellx9176\clvertalb\cellx10694\clvertalb\cellx10800\trrh1238
\pard\plain\intbl\li440\fi-220\cf1\f51\fs20\ql Issuance of common stock in\plain\intbl\li440\cf1\f51\fs20\ql connection with\plain\intbl\li440\cf1\f51\fs20\ql February\~2019 Public\plain\intbl\li440\cf1\f51\fs20\ql Offering, net of issuance\plain\intbl\li440\cf1\f51\fs20\ql costs of $1,102\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 7,557,142\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 7\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 12,115\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \u8212?\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \u8212?\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 12,122\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\cellx2677\clvertalb\cellx2824\clvertalb\cellx3771\clvertalb\cellx4128\clvertalb\cellx4956\clvertalb\cellx5103\clvertalb\cellx6251\clvertalb\cellx6398\clvertalb\cellx7713\clvertalb\cellx7811\clvertalb\cellx9078\clvertalb\cellx9176\clvertalb\cellx10694\clvertalb\cellx10800\trrh1238\row}}}
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx2677\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx2824\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx3771\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4128\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4956\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5103\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6251\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6398\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7713\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7811\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9078\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9176\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10694\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10800\trrh743
\pard\plain\intbl\li440\fi-220\cf1\f51\fs20\ql Record the value of the\plain\intbl\li440\cf1\f51\fs20\ql effect of the down round\plain\intbl\li440\cf1\f51\fs20\ql feature as a dividend\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \u8212?\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \u8212?\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 359\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \u8212?\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr (359\cell\pard\plain\intbl\cf1\f51\fs20\ql )\cell\pard\plain\intbl\cf1\f51\fs20\qr \u8212?\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx2677\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx2824\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx3771\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4128\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4956\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5103\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6251\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6398\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7713\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7811\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9078\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9176\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10694\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10800\trrh743\row}}}
{\trowd\cellx2677\clvertalb\cellx2824\clvertalb\cellx3771\clvertalb\cellx4128\clvertalb\cellx4956\clvertalb\cellx5103\clvertalb\cellx6251\clvertalb\cellx6398\clvertalb\cellx7713\clvertalb\cellx7811\clvertalb\cellx9078\clvertalb\cellx9176\clvertalb\cellx10694\clvertalb\cellx10800\trrh495
\pard\plain\intbl\li440\fi-220\cf1\f51\fs20\ql Foreign currency translation\plain\intbl\li440\cf1\f51\fs20\ql adjustment\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \u8212?\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \u8212?\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \u8212?\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr (24\cell\pard\plain\intbl\cf1\f51\fs20\ql )\cell\pard\plain\intbl\cf1\f51\fs20\qr \u8212?\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr (24\cell\pard\plain\intbl\cf1\f51\fs20\ql )\cell{
{\trowd\cellx2677\clvertalb\cellx2824\clvertalb\cellx3771\clvertalb\cellx4128\clvertalb\cellx4956\clvertalb\cellx5103\clvertalb\cellx6251\clvertalb\cellx6398\clvertalb\cellx7713\clvertalb\cellx7811\clvertalb\cellx9078\clvertalb\cellx9176\clvertalb\cellx10694\clvertalb\cellx10800\trrh495\row}}}
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx2677\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx2824\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx3771\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4128\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4956\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5103\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6251\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6398\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7713\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7811\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9078\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9176\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10694\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10800\trrh248
\pard\plain\intbl\li440\fi-220\cf1\f51\fs20\ql Stock-based compensation\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \u8212?\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \u8212?\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 947\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \u8212?\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \u8212?\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 947\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx2677\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx2824\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx3771\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4128\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4956\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5103\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6251\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6398\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7713\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7811\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9078\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9176\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10694\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10800\trrh248\row}}}
{\trowd\cellx2677\clvertalb\cellx2824\clbrdrb\brdrs\brdrcf1\clvertalb\cellx3771\clvertalb\cellx4128\clbrdrb\brdrs\brdrcf1\clvertalb\cellx4956\clvertalb\cellx5103\clbrdrb\brdrs\brdrcf1\clvertalb\cellx6251\clvertalb\cellx6398\clbrdrb\brdrs\brdrcf1\clvertalb\cellx7713\clvertalb\cellx7811\clbrdrb\brdrs\brdrcf1\clvertalb\cellx9078\clvertalb\cellx9176\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10694\clvertalb\cellx10800\trrh248
\pard\plain\intbl\li440\fi-220\cf1\f51\fs20\ql Net loss\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \u8212?\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \u8212?\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \u8212?\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \u8212?\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr (8,603\cell\pard\plain\intbl\cf1\f51\fs20\ql )\cell\pard\plain\intbl\cf1\f51\fs20\qr (8,603\cell\pard\plain\intbl\cf1\f51\fs20\ql )\cell{
{\trowd\cellx2677\clvertalb\cellx2824\clbrdrb\brdrs\brdrcf1\clvertalb\cellx3771\clvertalb\cellx4128\clbrdrb\brdrs\brdrcf1\clvertalb\cellx4956\clvertalb\cellx5103\clbrdrb\brdrs\brdrcf1\clvertalb\cellx6251\clvertalb\cellx6398\clbrdrb\brdrs\brdrcf1\clvertalb\cellx7713\clvertalb\cellx7811\clbrdrb\brdrs\brdrcf1\clvertalb\cellx9078\clvertalb\cellx9176\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10694\clvertalb\cellx10800\trrh248\row}}}
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx2677\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx2824\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx3771\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4128\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4956\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5103\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5477\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6250\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6397\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6940\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7712\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7810\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8273\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9077\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9175\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9896\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10693\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10800\trrh248
\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\b\ql Balances at March\~31, 2019\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 22,260,301\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 22\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr 187,635\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr 278\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr (170,871\cell\pard\plain\intbl\cf1\f51\fs20\ql )\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr 17,064\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx2677\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx2824\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx3771\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4128\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4956\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5103\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5477\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6250\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6397\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6940\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7712\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7810\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8273\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9077\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9175\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9896\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10693\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10800\trrh248\row}}}\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\qc See notes to condensed consolidated financial statements.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\qc 8{\*\bkmkstart pb_8_022323_5796_12906402}{\*\bkmkend pb_8_022323_5796_12906402}\par\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par
\page\pard\plain\ul{\field{\*\fldinst HYPERLINK \\l "tableofcontents_12906402" }{\*\fldrslt\cf3\f51\fs20\ql Table of Contents}}\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\qc LEAP THERAPEUTICS,\~INC.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\qc CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\qc (In thousands)\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\qc (Unaudited)\par\pard\plain\cf1\f51\fs20\ql \~
\par\pard\plain
{\trowd\clvertalb\cellx7183\clvertalb\cellx7372\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10694\clvertalb\cellx10800\trrh198
\pard\plain\intbl\cf1\f51\fs2\b\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs16\b\qc Three\~Months\~Ended\~March\~31,\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell{
{\trowd\clvertalb\cellx7183\clvertalb\cellx7372\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10694\clvertalb\cellx10800\trrh198\row}}}
{\trowd\clvertalb\cellx7183\clvertalb\cellx7372\clbrdrb\brdrs\brdrcf1\clvertalb\cellx8802\clvertalb\cellx9246\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10694\clvertalb\cellx10800\trrh198
\pard\plain\intbl\cf1\f51\fs2\b\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs16\b\qc 2019\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs16\b\qc 2018\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell{
{\trowd\clvertalb\cellx7183\clvertalb\cellx7372\clbrdrb\brdrs\brdrcf1\clvertalb\cellx8802\clvertalb\cellx9246\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10694\clvertalb\cellx10800\trrh198\row}}}
{\trowd\cellx7183\clvertalb\cellx7372\clvertalb\cellx8802\clvertalb\cellx9246\clvertalb\cellx10694\clvertalb\cellx10800\trrh248
\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell{
{\trowd\cellx7183\clvertalb\cellx7372\clvertalb\cellx8802\clvertalb\cellx9246\clvertalb\cellx10694\clvertalb\cellx10800\trrh248\row}}}
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx7183\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7372\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8802\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9246\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10694\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10800\trrh248
\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\b\ql Cash flows from operating activities:\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\qr \~\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\qr \~\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx7183\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7372\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8802\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9246\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10694\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10800\trrh248\row}}}
{\trowd\cellx7183\clvertalb\cellx7372\clvertalb\cellx7816\clvertalb\cellx8802\clvertalb\cellx9246\clvertalb\cellx9690\clvertalb\cellx10694\clvertalb\cellx10800\trrh248
\pard\plain\intbl\li440\fi-220\cf1\f51\fs20\ql Net loss\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr (8,603\cell\pard\plain\intbl\cf1\f51\fs20\ql )\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr (10,622\cell\pard\plain\intbl\cf1\f51\fs20\ql )\cell{
{\trowd\cellx7183\clvertalb\cellx7372\clvertalb\cellx7816\clvertalb\cellx8802\clvertalb\cellx9246\clvertalb\cellx9690\clvertalb\cellx10694\clvertalb\cellx10800\trrh248\row}}}
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx7183\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7372\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8802\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9246\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10694\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10800\trrh248
\pard\plain\intbl\li440\fi-220\cf1\f51\fs20\ql Adjustments to reconcile net loss to net cash used in operating activities:\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\qr \~\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\qr \~\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx7183\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7372\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8802\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9246\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10694\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10800\trrh248\row}}}
{\trowd\cellx7183\clvertalb\cellx7372\clvertalb\cellx8802\clvertalb\cellx9246\clvertalb\cellx10694\clvertalb\cellx10800\trrh248
\pard\plain\intbl\li660\fi-220\cf1\f51\fs20\ql Depreciation expense\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 12\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 12\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\cellx7183\clvertalb\cellx7372\clvertalb\cellx8802\clvertalb\cellx9246\clvertalb\cellx10694\clvertalb\cellx10800\trrh248\row}}}
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx7183\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7372\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8802\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9246\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10694\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10800\trrh248
\pard\plain\intbl\li660\fi-220\cf1\f51\fs20\ql Amortization on right-of-use asset\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 177\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \u8212?\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx7183\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7372\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8802\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9246\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10694\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10800\trrh248\row}}}
{\trowd\cellx7183\clvertalb\cellx7372\clvertalb\cellx8802\clvertalb\cellx9246\clvertalb\cellx10694\clvertalb\cellx10800\trrh248
\pard\plain\intbl\li660\fi-220\cf1\f51\fs20\ql Stock-based compensation expense\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 947\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 728\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\cellx7183\clvertalb\cellx7372\clvertalb\cellx8802\clvertalb\cellx9246\clvertalb\cellx10694\clvertalb\cellx10800\trrh248\row}}}
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx7183\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7372\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8802\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9246\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10694\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10800\trrh248
\pard\plain\intbl\li660\fi-220\cf1\f51\fs20\ql Change in fair value of warrant liability\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \u8212?\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 4,851\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx7183\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7372\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8802\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9246\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10694\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10800\trrh248\row}}}
{\trowd\cellx7183\clvertalb\cellx7372\clvertalb\cellx8802\clvertalb\cellx9246\clvertalb\cellx10694\clvertalb\cellx10800\trrh248
\pard\plain\intbl\li660\fi-220\cf1\f51\fs20\ql Changes in operating assets and liabilities:\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\qr \~\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\qr \~\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\cellx7183\clvertalb\cellx7372\clvertalb\cellx8802\clvertalb\cellx9246\clvertalb\cellx10694\clvertalb\cellx10800\trrh248\row}}}
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx7183\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7372\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8802\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9246\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10694\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10800\trrh248
\pard\plain\intbl\li880\fi-220\cf1\f51\fs20\ql Prepaid expenses and other assets\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 43\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr (117\cell\pard\plain\intbl\cf1\f51\fs20\ql )\cell{
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx7183\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7372\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8802\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9246\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10694\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10800\trrh248\row}}}
{\trowd\cellx7183\clvertalb\cellx7372\clvertalb\cellx8802\clvertalb\cellx9246\clvertalb\cellx10694\clvertalb\cellx10800\trrh248
\pard\plain\intbl\li880\fi-220\cf1\f51\fs20\ql Research and development incentive receivable\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr (75\cell\pard\plain\intbl\cf1\f51\fs20\ql )\cell\pard\plain\intbl\cf1\f51\fs20\qr 89\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\cellx7183\clvertalb\cellx7372\clvertalb\cellx8802\clvertalb\cellx9246\clvertalb\cellx10694\clvertalb\cellx10800\trrh248\row}}}
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx7183\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7372\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8802\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9246\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10694\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10800\trrh248
\pard\plain\intbl\li880\fi-220\cf1\f51\fs20\ql Accounts payable and accrued expenses\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 780\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr (419\cell\pard\plain\intbl\cf1\f51\fs20\ql )\cell{
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx7183\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7372\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8802\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9246\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10694\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10800\trrh248\row}}}
{\trowd\cellx7183\clvertalb\cellx7372\clbrdrb\brdrs\brdrcf1\clvertalb\cellx8802\clvertalb\cellx9246\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10694\clvertalb\cellx10800\trrh248
\pard\plain\intbl\li880\fi-220\cf1\f51\fs20\ql Lease liability\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr (149\cell\pard\plain\intbl\cf1\f51\fs20\ql )\cell\pard\plain\intbl\cf1\f51\fs20\qr \u8212?\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\cellx7183\clvertalb\cellx7372\clbrdrb\brdrs\brdrcf1\clvertalb\cellx8802\clvertalb\cellx9246\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10694\clvertalb\cellx10800\trrh248\row}}}
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx7183\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7372\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8802\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9246\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10694\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10800\trrh248
\pard\plain\intbl\li880\fi-220\cf1\f51\fs20\ql Net cash used in operating activities\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr (6,868\cell\pard\plain\intbl\cf1\f51\fs20\ql )\cell\pard\plain\intbl\cf1\f51\fs20\qr (5,478\cell\pard\plain\intbl\cf1\f51\fs20\ql )\cell{
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx7183\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7372\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8802\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9246\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10694\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10800\trrh248\row}}}
{\trowd\cellx7183\clvertalb\cellx7372\clvertalb\cellx8802\clvertalb\cellx9246\clvertalb\cellx10694\clvertalb\cellx10800\trrh248
\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\b\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell{
{\trowd\cellx7183\clvertalb\cellx7372\clvertalb\cellx8802\clvertalb\cellx9246\clvertalb\cellx10694\clvertalb\cellx10800\trrh248\row}}}
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx7183\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7372\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8802\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9246\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10694\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10800\trrh248
\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\b\ql Cash flows from financing activities:\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\qr \~\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\qr \~\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx7183\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7372\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8802\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9246\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10694\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10800\trrh248\row}}}
{\trowd\cellx7183\clvertalb\cellx7372\clvertalb\cellx8802\clvertalb\cellx9246\clvertalb\cellx10694\clvertalb\cellx10800\trrh495
\pard\plain\intbl\li440\fi-220\cf1\f51\fs20\ql Proceeds from issuance of common stock, net of underwriter commissions and\plain\intbl\li440\cf1\f51\fs20\ql discounts\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 12,331\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 15,033\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\cellx7183\clvertalb\cellx7372\clvertalb\cellx8802\clvertalb\cellx9246\clvertalb\cellx10694\clvertalb\cellx10800\trrh495\row}}}
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx7183\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7372\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8802\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9246\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10694\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10800\trrh248
\pard\plain\intbl\li440\fi-220\cf1\f51\fs20\ql Payment of deferred offering costs\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr (9\cell\pard\plain\intbl\cf1\f51\fs20\ql )\cell\pard\plain\intbl\cf1\f51\fs20\qr (28\cell\pard\plain\intbl\cf1\f51\fs20\ql )\cell{
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx7183\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7372\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8802\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9246\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10694\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10800\trrh248\row}}}
{\trowd\cellx7183\clvertalb\cellx7372\clbrdrb\brdrs\brdrcf1\clvertalb\cellx8802\clvertalb\cellx9246\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10694\clvertalb\cellx10800\trrh248
\pard\plain\intbl\li880\fi-220\cf1\f51\fs20\ql Net cash provided by financing activities\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 12,322\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 15,005\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\cellx7183\clvertalb\cellx7372\clbrdrb\brdrs\brdrcf1\clvertalb\cellx8802\clvertalb\cellx9246\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10694\clvertalb\cellx10800\trrh248\row}}}
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx7183\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7372\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8802\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9246\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10694\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10800\trrh248
\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell{
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx7183\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7372\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8802\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9246\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10694\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10800\trrh248\row}}}
{\trowd\cellx7183\clvertalb\cellx7372\clbrdrb\brdrs\brdrcf1\clvertalb\cellx8802\clvertalb\cellx9246\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10694\clvertalb\cellx10800\trrh248
\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\b\ql Effect of exchange rate changes on cash and cash equivalents\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr (29\cell\pard\plain\intbl\cf1\f51\fs20\ql )\cell\pard\plain\intbl\cf1\f51\fs20\qr 112\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\cellx7183\clvertalb\cellx7372\clbrdrb\brdrs\brdrcf1\clvertalb\cellx8802\clvertalb\cellx9246\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10694\clvertalb\cellx10800\trrh248\row}}}
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx7183\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7372\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8802\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9246\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10694\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10800\trrh248
\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\b\ql Net increase in cash and cash equivalents\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 5,425\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 9,639\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx7183\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7372\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8802\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9246\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10694\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10800\trrh248\row}}}
{\trowd\cellx7183\clvertalb\cellx7372\clbrdrb\brdrs\brdrcf1\clvertalb\cellx8802\clvertalb\cellx9246\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10694\clvertalb\cellx10800\trrh248
\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\ql Cash and cash equivalents at beginning of period\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 16,284\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 25,737\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\cellx7183\clvertalb\cellx7372\clbrdrb\brdrs\brdrcf1\clvertalb\cellx8802\clvertalb\cellx9246\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10694\clvertalb\cellx10800\trrh248\row}}}
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx7183\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7372\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7816\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8802\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9246\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9690\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10694\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10800\trrh248
\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\ql Cash and cash equivalents at end of period\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr 21,709\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr 35,376\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx7183\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7372\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7816\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8802\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9246\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9690\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10694\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10800\trrh248\row}}}
{\trowd\cellx7183\clvertalb\cellx7372\clvertalb\cellx8802\clvertalb\cellx9246\clvertalb\cellx10694\clvertalb\cellx10800\trrh248
\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell{
{\trowd\cellx7183\clvertalb\cellx7372\clvertalb\cellx8802\clvertalb\cellx9246\clvertalb\cellx10694\clvertalb\cellx10800\trrh248\row}}}
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx7183\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7372\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8802\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9246\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10694\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10800\trrh248
\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\b\ql Supplemental disclosure of non-cash financing activities:\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\qr \~\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\qr \~\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx7183\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7372\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8802\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9246\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10694\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10800\trrh248\row}}}
{\trowd\cellx7183\clvertalb\cellx7372\clvertalb\cellx7816\clvertalb\cellx8802\clvertalb\cellx9246\clvertalb\cellx9690\clvertalb\cellx10694\clvertalb\cellx10800\trrh248
\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\ql Reclassification of 2017 Warrants from liability to equity\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr 3,447\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr \u8212?\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\cellx7183\clvertalb\cellx7372\clvertalb\cellx7816\clvertalb\cellx8802\clvertalb\cellx9246\clvertalb\cellx9690\clvertalb\cellx10694\clvertalb\cellx10800\trrh248\row}}}
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx7183\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7372\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7816\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8802\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9246\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9690\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10694\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10800\trrh248
\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\ql Dividend attributable to down round feature of warrants\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr 359\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr \u8212?\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx7183\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7372\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7816\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8802\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9246\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9690\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10694\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10800\trrh248\row}}}
{\trowd\cellx7183\clvertalb\cellx7372\clvertalb\cellx7816\clvertalb\cellx8802\clvertalb\cellx9246\clvertalb\cellx9690\clvertalb\cellx10694\clvertalb\cellx10800\trrh248
\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\ql Offering costs included in accounts payable and accrued expenses\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr 213\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr 210\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\cellx7183\clvertalb\cellx7372\clvertalb\cellx7816\clvertalb\cellx8802\clvertalb\cellx9246\clvertalb\cellx9690\clvertalb\cellx10694\clvertalb\cellx10800\trrh248\row}}}
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx7183\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7372\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7816\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8802\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9246\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9690\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10694\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10800\trrh248
\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\ql Right-of-use asset recorded upon adoption of ASU 2016-02\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr 1,755\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \u8212?\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx7183\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7372\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7816\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8802\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9246\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9690\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10694\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10800\trrh248\row}}}
{\trowd\cellx7183\clvertalb\cellx7372\clvertalb\cellx7816\clvertalb\cellx8802\clvertalb\cellx9246\clvertalb\cellx9690\clvertalb\cellx10694\clvertalb\cellx10800\trrh248
\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\ql Lease liability recorded upon adoption of ASU 2016-02\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr 1,720\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \u8212?\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
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\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\ql Accrued rent reclassified upon adoption of ASU 2016-02\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr 35\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \u8212?\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx7183\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7372\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7816\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8802\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9246\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9690\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10694\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10800\trrh248\row}}}\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\qc See notes to condensed consolidated financial statements.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\qc 9{\*\bkmkstart pb_9_022651_2897_12906402}{\*\bkmkend pb_9_022651_2897_12906402}\par\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par
\page\pard\plain\ul{\field{\*\fldinst HYPERLINK \\l "tableofcontents_12906402" }{\*\fldrslt\cf3\f51\fs20\ql Table of Contents}}\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\qc Leap Therapeutics,\~Inc.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\qc NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\qc (In thousands, except share and per share amounts)\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\qc (Unaudited)\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\ql 1. Nature of Business, Basis of Presentation and Liquidity\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\li308\fi-308\cf1\f51\fs20\i\ql Nature of Business\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi616\cf1\f51\fs20\ql Leap Therapeutics,\~Inc. was incorporated in the state of Delaware as Dekkun Corporation on January\~3, 2011 and changed\plain\cf1\f51\fs20\ql its name to HealthCare Pharmaceuticals,\~Inc. effective May\~29, 2014, and then to Leap Therapeutics,\~Inc. effective November\~16,\plain\cf1\f51\fs20\ql 2015 (the \u8220?Company\u8221?). During 2015, HealthCare Pharmaceuticals Pty\~Ltd. (\u8220?HCP Australia\u8221?) was\plain\cf1\f51\fs20\ql formed and is a wholly owned subsidiary of the Company. During 2017, the Company merged with Macrocure\~Ltd. (now\plain\cf1\f51\fs20\ql \u8220?Leap Therapeutics\~Ltd.\u8221?) and its wholly owned subsidiary Macrocure,\~Inc.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi616\cf1\f51\fs20\ql The Company is a biopharmaceutical company acquiring and developing novel therapeutics at the leading edge of cancer\plain\cf1\f51\fs20\ql biology. The Company\u8217?s approach is designed to target compelling tumor-promoting and immuno-oncology pathways to\plain\cf1\f51\fs20\ql generate durable clinical benefit and enhanced outcomes for patients. The Company\u8217?s programs are monoclonal antibodies\plain\cf1\f51\fs20\ql that target key cellular pathways that enable cancer to grow and spread and specific mechanisms that activate the body\u8217?s\plain\cf1\f51\fs20\ql immune system to identify and attack cancer.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\li308\fi-308\cf1\f51\fs20\i\ql Basis of Presentation\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi726\cf1\f51\fs20\ql The accompanying condensed consolidated financial statements as of March\~31, 2019 and for the three months ended\plain\cf1\f51\fs20\ql March\~31, 2019 and 2018 have been prepared by the Company, pursuant to the rules\~and regulations of the Securities and\plain\cf1\f51\fs20\ql Exchange Commission (the \u8220?SEC\u8221?) for interim financial statements. Certain information and footnote disclosures\plain\cf1\f51\fs20\ql normally included in financial statements prepared in accordance with accounting principles generally accepted in the United\plain\cf1\f51\fs20\ql States of America (\u8220?GAAP\u8221?) have been condensed or omitted pursuant to such rules\~and regulations. However, the\plain\cf1\f51\fs20\ql Company believes that the disclosures are adequate to make the information presented not misleading. These condensed\plain\cf1\f51\fs20\ql consolidated financial statements should be read in conjunction with the Company\u8217?s\~audited consolidated financial\plain\cf1\f51\fs20\ql statements and the notes thereto for the year ended December\~31, 2018 included in the Company\u8217?s\~Annual Report on\plain\cf1\f51\fs20\ql Form\~10-K filed with the SEC on April\~1, 2019.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi726\cf1\f51\fs20\ql The condensed consolidated financial statements have been prepared on the same basis as the audited consolidated\plain\cf1\f51\fs20\ql financial statements. In the opinion of management, the accompanying condensed consolidated financial statements contain all\plain\cf1\f51\fs20\ql adjustments which are necessary for the fair presentation of the Company\u8217?s financial position as of March\~31, 2019,\plain\cf1\f51\fs20\ql statements of operations and statements of comprehensive loss for the three months ended March\~31, 2019 and 2018 and\plain\cf1\f51\fs20\ql statements of cash flows for the three months ended March\~31, 2019 and 2018.\~ Such adjustments are of a normal and recurring\plain\cf1\f51\fs20\ql nature. The results of operations for the three months ended March\~31, 2019 are not necessarily indicative of the results of\plain\cf1\f51\fs20\ql operations that may be expected for the year ending December\~31, 2019.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\li308\fi-308\cf1\f51\fs20\i\ql Liquidity\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi616\cf1\f51\fs20\ql Since inception, the Company has been engaged in organizational activities, including raising capital, and research and\plain\cf1\f51\fs20\ql development activities. The Company does not yet have a product that has been approved by the Food and Drug Administration\plain\cf1\f51\fs20\ql (the \u8220?FDA\u8221?), has not generated any revenues and has not yet achieved profitable operations, nor has it ever\plain\cf1\f51\fs20\ql generated positive cash flows from operations. There is no assurance that profitable operations, if achieved, could be sustained on\plain\cf1\f51\fs20\ql a continuing basis. Further, the Company\u8217?s future operations are dependent on the success of the Company\u8217?s efforts\plain\cf1\f51\fs20\ql to raise additional capital, its research and commercialization efforts, regulatory approval, and, ultimately, the market acceptance\plain\cf1\f51\fs20\ql of the Company\u8217?s products.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\qc 10{\*\bkmkstart pb_10_015436_4043_12906402}{\*\bkmkend pb_10_015436_4043_12906402}\par\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par
\page\pard\plain\ul{\field{\*\fldinst HYPERLINK \\l "tableofcontents_12906402" }{\*\fldrslt\cf3\f51\fs20\ql Table of Contents}}\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi440\cf1\f51\fs20\ql In accordance with Accounting Standards Codification (\u8220?ASC\u8221?) 205-40, Going Concern, the Company has\plain\cf1\f51\fs20\ql evaluated whether there are conditions and events, considered in the aggregate, that raise substantial doubt about the\plain\cf1\f51\fs20\ql Company\u8217?s ability to continue as a going concern within one year after the date that the condensed consolidated financial\plain\cf1\f51\fs20\ql statements are issued. As of March\~31, 2019, the Company had an accumulated deficit of $170,871, and during the three months\plain\cf1\f51\fs20\ql ended March\~31, 2019, the Company incurred a net loss of $8,603. The Company expects to continue to generate operating losses\plain\cf1\f51\fs20\ql in the foreseeable future. The Company had cash and cash equivalents of $21,709 at March\~31, 2019. The foregoing matters give\plain\cf1\f51\fs20\ql rise to a substantial doubt about the Company\u8217?s ability to continue as a going concern for one year after the\plain\cf1\f51\fs20\ql Company\u8217?s financial statements have been issued. The Company will seek additional funding through public or private\plain\cf1\f51\fs20\ql equity financings or government programs and will seek funding or development program cost-sharing through collaboration\plain\cf1\f51\fs20\ql agreements or licenses with larger pharmaceutical or biotechnology companies. If the Company does not obtain additional\plain\cf1\f51\fs20\ql funding or development program cost-sharing, the Company will be forced to delay, reduce or eliminate certain clinical trials or\plain\cf1\f51\fs20\ql research and development programs, reduce or eliminate discretionary operating expenses, and delay company and pipeline\plain\cf1\f51\fs20\ql expansion, which would adversely affect its business prospects. The inability to obtain funding, as and when needed, would have\plain\cf1\f51\fs20\ql a negative impact on the Company\u8217?s financial condition and ability to pursue its business strategies.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\ql 2. Summary of Significant Accounting Policies\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\li308\fi-308\cf1\f51\fs20\i\ql Principles of Consolidation\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi616\cf1\f51\fs20\ql The accompanying condensed consolidated financial statements include the accounts of the Company and its wholly\plain\cf1\f51\fs20\ql owned subsidiaries. All intercompany accounts and transactions are eliminated upon consolidation.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\li308\fi-308\cf1\f51\fs20\i\ql Use of Estimates\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi616\cf1\f51\fs20\ql The presentation of condensed consolidated financial statements in conformity with GAAP requires management to make\plain\cf1\f51\fs20\ql estimates and assumptions that affect the reported amounts of assets and liabilities and disclosure of contingent assets and\plain\cf1\f51\fs20\ql liabilities at the date of the condensed consolidated financial statements and the reported amounts of revenues and expenses\plain\cf1\f51\fs20\ql during the reporting period. Actual results could differ from those estimates.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\li308\fi-308\cf1\f51\fs20\i\ql Research and development incentive income and receivable\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi616\cf1\f51\fs20\ql The Company recognizes other income from Australian research and development incentives when there is reasonable\plain\cf1\f51\fs20\ql assurance that the income will be received, the relevant expenditure has been incurred, and the consideration can be reliably\plain\cf1\f51\fs20\ql measured. The research and development incentive is one of the key elements of the Australian Government\u8217?s support for\plain\cf1\f51\fs20\ql Australia\u8217?s innovation system and is supported by legislative law primarily in the form of the Australian Income Tax\plain\cf1\f51\fs20\ql Assessment Act 1997, as long as eligibility criteria are met.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi616\cf1\f51\fs20\ql Management has assessed the Company\u8217?s research and development activities and expenditures to determine which\plain\cf1\f51\fs20\ql activities and expenditures are likely to be eligible under the research and development incentive regime described above. At each\plain\cf1\f51\fs20\ql period end, management estimates the refundable tax offset available to the Company based on available information at the time.\plain\cf1\f51\fs20\ql This estimate is also reviewed by external tax advisors on an annual basis.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi616\cf1\f51\fs20\ql Under the program, a percentage of eligible research and development expenses incurred by the Company through its\plain\cf1\f51\fs20\ql subsidiary in Australia are reimbursed.\~ The percentage was 43.5% for the year ended December\~31, 2018 and for the three\plain\cf1\f51\fs20\ql months ended March\~31, 2019.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi616\cf1\f51\fs20\ql The research and development incentive receivable represents an amount due in connection with the above program. The\plain\cf1\f51\fs20\ql Company has recorded a research and development incentive receivable of $918 and $836 as of\~March\~31, 2019 and\plain\cf1\f51\fs20\ql December\~31, 2018, respectively, in the condensed consolidated balance sheets and other income from Australian research and\plain\cf1\f51\fs20\ql development incentives of $75 and $646, respectively, for the three months ended March\~31, 2019 and 2018 in the condensed\plain\cf1\f51\fs20\ql consolidated statements of operations related to refundable research and development incentive program payments in Australia.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi616\cf1\f51\fs20\ql The following table shows the change in the research and development incentive receivable from December\~31, 2017 to\plain\cf1\f51\fs20\ql March\~31, 2019 (in thousands):\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\qc 11{\*\bkmkstart pb_11_015732_7056_12906402}{\*\bkmkend pb_11_015732_7056_12906402}\par\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par
\page\pard\plain\ul{\field{\*\fldinst HYPERLINK \\l "tableofcontents_12906402" }{\*\fldrslt\cf3\f51\fs20\ql Table of Contents}}\par\pard\plain\cf1\f51\fs20\ql \~
\par\pard\plain
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\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\ql Balance at December\~31, 2017\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr 1,744\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx6541\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6775\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6899\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7795\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7884\trrh248\row}}}
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\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\ql Australian research and development incentive income\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 756\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\cellx6541\clvertalb\cellx6775\clvertalb\cellx7796\clvertalb\cellx7884\trrh248\row}}}
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\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\ql Cash received for 2016 eligible overseas research and development expenses\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr (740\cell\pard\plain\intbl\cf1\f51\fs20\ql )\cell{
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{\trowd\cellx6541\clvertalb\cellx6775\clvertalb\cellx7796\clvertalb\cellx7884\trrh248
\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\ql Cash received for 2017 eligible expenses\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr (793\cell\pard\plain\intbl\cf1\f51\fs20\ql )\cell{
{\trowd\cellx6541\clvertalb\cellx6775\clvertalb\cellx7796\clvertalb\cellx7884\trrh248\row}}}
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx6541\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6775\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7796\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7884\trrh248
\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\ql Foreign currency translation\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr (131\cell\pard\plain\intbl\cf1\f51\fs20\ql )\cell{
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{\trowd\cellx6541\clvertalb\cellx6775\clvertalb\cellx7796\clvertalb\cellx7884\trrh248
\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\ql Balance at December\~31, 2018\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 836\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\cellx6541\clvertalb\cellx6775\clvertalb\cellx7796\clvertalb\cellx7884\trrh248\row}}}
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\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\ql Australian research and development incentive income\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 75\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
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\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\ql Foreign currency translation\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 7\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\cellx6541\clvertalb\cellx6775\clbrdrb\brdrs\brdrcf1\clvertalb\cellx7796\clvertalb\cellx7884\trrh248\row}}}
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx6541\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6775\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6899\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7795\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7884\trrh248
\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\ql Balance at March 31, 2019\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr 918\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx6541\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6775\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6899\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7795\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7884\trrh248\row}}}\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi44\cf1\f51\fs20\i\ql Foreign Currency Translation\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi616\cf1\f51\fs20\ql The financial statements of the Company\u8217?s Australian subsidiary are measured using the local currency as the\plain\cf1\f51\fs20\ql functional currency. Assets and liabilities of this subsidiary are translated into U.S. dollars at an exchange rate as of the\plain\cf1\f51\fs20\ql consolidated balance sheet date. Equity is translated at historical exchange rates. Revenues and expenses are translated into U.S.\plain\cf1\f51\fs20\ql dollars at average rates of exchange in effect during the year. The resulting cumulative translation adjustments have been\plain\cf1\f51\fs20\ql recorded as a separate component of stockholders\u8217? equity. Realized foreign currency transaction gains and losses are\plain\cf1\f51\fs20\ql included in the results of operations.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\i\ql Other Assets\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi616\cf1\f51\fs20\ql Other assets as of March\~31, 2019 and December\~31, 2018 included $1,344 and $1,380, respectively, of deposits made by\plain\cf1\f51\fs20\ql the Company with certain service providers that are to be applied to future payments due under the service agreements or\plain\cf1\f51\fs20\ql returned to the Company if not utilized.\~ In addition, as of March\~31, 2019 and December 31, 2018 other assets included $175\plain\cf1\f51\fs20\ql and $162 of deferred issuance costs, respectively.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\i\ql Warrants\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi638\cf1\f51\fs20\ql On January\~1, 2019, the Company adopted ASU\~No.\~2017-11,\plain\cf1\f51\fs20\i\ql Earnings Per Share (Topic\~260), Distinguishing Liabilities\plain\cf1\f51\fs20\i\ql from Equity (Topic\~480), and Derivatives and Hedging (Topic\~815)\plain\cf1\f51\fs20\ql \~ (\u8220?ASU\~2017-11\u8221?), which changes the\plain\cf1\f51\fs20\ql classification analysis of certain equity-linked financial instruments (or embedded features) with down round features. The\plain\cf1\f51\fs20\ql amendments require entities that present earnings per share (\u8220?EPS\u8221?) in accordance with Topic\~260 to recognize the\plain\cf1\f51\fs20\ql effect of the down round feature when triggered with the effect treated as a dividend and as a reduction of income available to\plain\cf1\f51\fs20\ql common shareholders in basic EPS.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi638\cf1\f51\fs20\ql The Company concluded that the 2017 Warrants issued in connection with the Private Placement, qualify for equity\plain\cf1\f51\fs20\ql classification.\~ The adoption guidance of ASU 2017-11 provides for a modified retrospective adoption.\~ The Company applied the\plain\cf1\f51\fs20\ql guidance retrospectively to the 2017 Warrants by means of a cumulative-effect adjustment to its statement of financial position\plain\cf1\f51\fs20\ql as of the beginning of the interim and annual period beginning January\~1, 2019.\~ The Company performed a final remeasurement\plain\cf1\f51\fs20\ql of the warrant liability as of January\~1, 2019 and reclassified $3,448 to additional paid-in capital.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi638\cf1\f51\fs20\ql The Company will recognize on a prospective basis the value of the effect of the down round feature in the 2017 warrants\plain\cf1\f51\fs20\ql when it is triggered (i.e., when the exercise price is adjusted downward). This value is measured as the difference between (1)\~the\plain\cf1\f51\fs20\ql financial instrument\u8217?s fair value (without the down round feature) using the pre-trigger exercise price and (2)\~the financial\plain\cf1\f51\fs20\ql instrument\u8217?s fair value (with the down round feature) using the reduced exercise price. The value of the effect of the down\plain\cf1\f51\fs20\ql round feature will be treated as a dividend and a reduction to income available to common shareholders in the basic EPS\plain\cf1\f51\fs20\ql calculation.\~ In connection with the 2019 Public Offering, when the 2017 Warrants were repriced from $6.085 to $1.75 as a result\plain\cf1\f51\fs20\ql of a down round, the Company recorded a dividend of $359 during the three months ended March\~31, 2019.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\i\ql Fair Value of Financial Instruments\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi638\cf1\f51\fs20\ql Certain assets and liabilities are carried at fair value under GAAP. Fair value is defined as the exchange price that would\plain\cf1\f51\fs20\ql be received for an asset or paid to transfer a liability (an exit price) in the principal or most advantageous market for the asset or\plain\cf1\f51\fs20\ql liability in an orderly transaction between market participants on the measurement date. Valuation techniques used to measure fair\plain\cf1\f51\fs20\ql value must maximize the use of observable inputs and minimize the use of unobservable inputs. Financial assets and liabilities\plain\cf1\f51\fs20\ql carried at fair value are to be classified and disclosed in one of the following three levels of the fair value hierarchy, of which\plain\cf1\f51\fs20\ql the first two are considered observable and the last is considered unobservable:\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\li990\fi-308\cf1\f53\fs20\ql ·\plain\li990\cf1\f51\fs20\ql \~\~\~\~\~\~ Level\~1\u8212?Quoted prices in active markets for identical assets or liabilities.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\li990\fi-308\cf1\f53\fs20\ql ·\plain\li990\cf1\f51\fs20\ql \~\~\~\~\~\~ Level\~2\u8212?Observable inputs (other than Level\~1 quoted prices), such as quoted prices in active markets for\plain\li990\cf1\f51\fs20\ql similar assets or liabilities, quoted prices in markets that are not active for identical or similar assets or liabilities, or\plain\li990\cf1\f51\fs20\ql other inputs that are observable or can be corroborated by observable market data.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\li990\fi-286\cf1\f53\fs20\ql ·\plain\li990\cf1\f51\fs20\ql \~\~\~\~\~\~ Level\~3\u8212?Unobservable inputs that are supported by little or no market activity and that are significant to\plain\li990\cf1\f51\fs20\ql determining the fair value of the assets or liabilities, including pricing models, discounted cash flow methodologies\plain\li990\cf1\f51\fs20\ql and similar techniques.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi638\cf1\f51\fs20\ql During the periods presented, the Company has not changed the manner in which it values assets and liabilities that are\plain\cf1\f51\fs20\ql measured at fair value using Level\~3 inputs. The Company recognizes transfers between levels of the fair value hierarchy as of\plain\cf1\f51\fs20\ql the end of the reporting period. There were no transfers within the hierarchy during the nine months ended March\~31, 2019 and\plain\cf1\f51\fs20\ql the year ended December\~31, 2018.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi638\cf1\f51\fs20\ql A summary of the assets and liabilities carried at fair value in accordance with the hierarchy defined above is as follows\plain\cf1\f51\fs20\ql (in thousands):\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\qc 12{\*\bkmkstart pb_12_015953_5335_12906402}{\*\bkmkend pb_12_015953_5335_12906402}\par\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par
\page\pard\plain\ul{\field{\*\fldinst HYPERLINK \\l "tableofcontents_12906402" }{\*\fldrslt\cf3\f51\fs20\ql Table of Contents}}\par\pard\plain\cf1\f51\fs20\ql \~
\par\pard\plain
{\trowd\clvertalb\cellx4319\clvertalb\cellx4503\clbrdrb\brdrs\brdrcf1\clvertalb\cellx5642\clvertalb\cellx5826\clbrdrb\brdrs\brdrcf1\clvertalb\cellx7040\clvertalb\cellx7224\clbrdrb\brdrs\brdrcf1\clvertalb\cellx8438\clvertalb\cellx8622\clbrdrb\brdrs\brdrcf1\clvertalb\cellx9836\clvertalb\cellx9936\trrh198
\pard\plain\intbl\cf1\f51\fs2\b\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs16\b\qc Total\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs16\b\qc Level\~1\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs16\b\qc Level\~2\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs16\b\qc Level\~3\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell{
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\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\b\ul\ql March\~31, 2019\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\qr \~\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\qr \~\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\qr \~\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\qr \~\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
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{\trowd\cellx4319\clvertalb\cellx4503\clvertalb\cellx5642\clvertalb\cellx5826\clvertalb\cellx7040\clvertalb\cellx7224\clvertalb\cellx8438\clvertalb\cellx8622\clvertalb\cellx9836\clvertalb\cellx9936\trrh248
\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\b\ql Assets:\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\qr \~\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\qr \~\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\qr \~\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\qr \~\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
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{\trowd\clshdng100\clcfpat11\clcbpat11\cellx4319\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4503\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4695\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5642\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5826\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6082\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7039\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7223\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7479\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8436\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8620\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8876\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9833\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9936\trrh248
\pard\plain\intbl\li440\fi-220\cf1\f51\fs20\ql Cash equivalents\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr 21,709\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr 21,709\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr \u8212?\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr \u8212?\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
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{\trowd\cellx4319\clvertalb\cellx4503\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx4695\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx5642\clvertalb\cellx5826\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx6082\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx7039\clvertalb\cellx7223\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx7479\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx8436\clvertalb\cellx8620\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx8876\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx9833\clvertalb\cellx9936\trrh248
\pard\plain\intbl\li660\fi-220\cf1\f51\fs20\ql Total assets\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr 21,709\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr 21,709\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs2\qr \~\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr \u8212?\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
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{\trowd\clshdng100\clcfpat11\clcbpat11\cellx4319\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4503\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5642\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5826\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7040\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7224\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8438\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8622\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9836\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9936\trrh248
\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell{
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx4319\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4503\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5642\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5826\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7040\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7224\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8438\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8622\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9836\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9936\trrh248\row}}}
{\trowd\cellx4319\clvertalb\cellx4503\clvertalb\cellx5642\clvertalb\cellx5826\clvertalb\cellx7040\clvertalb\cellx7224\clvertalb\cellx8438\clvertalb\cellx8622\clvertalb\cellx9836\clvertalb\cellx9936\trrh248
\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\b\ul\ql December\~31, 2018\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\qr \~\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\qr \~\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\qr \~\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\qr \~\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\cellx4319\clvertalb\cellx4503\clvertalb\cellx5642\clvertalb\cellx5826\clvertalb\cellx7040\clvertalb\cellx7224\clvertalb\cellx8438\clvertalb\cellx8622\clvertalb\cellx9836\clvertalb\cellx9936\trrh248\row}}}
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx4319\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4503\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5642\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5826\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7040\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7224\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8438\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8622\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9836\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9936\trrh248
\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\b\ql Assets:\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\qr \~\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\qr \~\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\qr \~\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\qr \~\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx4319\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4503\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5642\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5826\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7040\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7224\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8438\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8622\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9836\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9936\trrh248\row}}}
{\trowd\cellx4319\clvertalb\cellx4503\clbrdrb\brdrs\brdrcf1\clvertalb\cellx4695\clbrdrb\brdrs\brdrcf1\clvertalb\cellx5642\clvertalb\cellx5826\clbrdrb\brdrs\brdrcf1\clvertalb\cellx6082\clbrdrb\brdrs\brdrcf1\clvertalb\cellx7039\clvertalb\cellx7223\clbrdrb\brdrs\brdrcf1\clvertalb\cellx7479\clbrdrb\brdrs\brdrcf1\clvertalb\cellx8436\clvertalb\cellx8620\clbrdrb\brdrs\brdrcf1\clvertalb\cellx8876\clbrdrb\brdrs\brdrcf1\clvertalb\cellx9833\clvertalb\cellx9936\trrh248
\pard\plain\intbl\li440\fi-220\cf1\f51\fs20\ql Cash equivalents\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr 16,284\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr 16,284\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr \u8212?\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr \u8212?\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\cellx4319\clvertalb\cellx4503\clbrdrb\brdrs\brdrcf1\clvertalb\cellx4695\clbrdrb\brdrs\brdrcf1\clvertalb\cellx5642\clvertalb\cellx5826\clbrdrb\brdrs\brdrcf1\clvertalb\cellx6082\clbrdrb\brdrs\brdrcf1\clvertalb\cellx7039\clvertalb\cellx7223\clbrdrb\brdrs\brdrcf1\clvertalb\cellx7479\clbrdrb\brdrs\brdrcf1\clvertalb\cellx8436\clvertalb\cellx8620\clbrdrb\brdrs\brdrcf1\clvertalb\cellx8876\clbrdrb\brdrs\brdrcf1\clvertalb\cellx9833\clvertalb\cellx9936\trrh248\row}}}
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx4319\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4503\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4695\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5642\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5826\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6082\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7039\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7223\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7479\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8436\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8620\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8876\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9833\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9936\trrh248
\pard\plain\intbl\li660\fi-220\cf1\f51\fs20\ql Total assets\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr 16,284\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr 16,284\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr \u8212?\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr \u8212?\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx4319\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4503\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4695\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5642\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5826\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6082\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7039\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7223\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7479\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8436\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8620\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8876\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9833\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9936\trrh248\row}}}
{\trowd\cellx4319\clvertalb\cellx4503\clvertalb\cellx5642\clvertalb\cellx5826\clvertalb\cellx7040\clvertalb\cellx7224\clvertalb\cellx8438\clvertalb\cellx8622\clvertalb\cellx9836\clvertalb\cellx9936\trrh248
\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell{
{\trowd\cellx4319\clvertalb\cellx4503\clvertalb\cellx5642\clvertalb\cellx5826\clvertalb\cellx7040\clvertalb\cellx7224\clvertalb\cellx8438\clvertalb\cellx8622\clvertalb\cellx9836\clvertalb\cellx9936\trrh248\row}}}
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx4319\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4503\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5642\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5826\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7040\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7224\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8438\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8622\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9836\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9936\trrh248
\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\b\ql Liabilities:\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\qr \~\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\qr \~\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\qr \~\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\qr \~\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx4319\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4503\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5642\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5826\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7040\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7224\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8438\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8622\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9836\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9936\trrh248\row}}}
{\trowd\cellx4319\clvertalb\cellx4503\clbrdrb\brdrs\brdrcf1\clvertalb\cellx4695\clbrdrb\brdrs\brdrcf1\clvertalb\cellx5642\clvertalb\cellx5826\clbrdrb\brdrs\brdrcf1\clvertalb\cellx6082\clbrdrb\brdrs\brdrcf1\clvertalb\cellx7039\clvertalb\cellx7223\clbrdrb\brdrs\brdrcf1\clvertalb\cellx7479\clbrdrb\brdrs\brdrcf1\clvertalb\cellx8436\clvertalb\cellx8620\clbrdrb\brdrs\brdrcf1\clvertalb\cellx8876\clbrdrb\brdrs\brdrcf1\clvertalb\cellx9833\clvertalb\cellx9936\trrh248
\pard\plain\intbl\li440\fi-220\cf1\f51\fs20\ql Warrant liability\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr 3,448\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr \u8212?\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr \u8212?\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr 3,448\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\cellx4319\clvertalb\cellx4503\clbrdrb\brdrs\brdrcf1\clvertalb\cellx4695\clbrdrb\brdrs\brdrcf1\clvertalb\cellx5642\clvertalb\cellx5826\clbrdrb\brdrs\brdrcf1\clvertalb\cellx6082\clbrdrb\brdrs\brdrcf1\clvertalb\cellx7039\clvertalb\cellx7223\clbrdrb\brdrs\brdrcf1\clvertalb\cellx7479\clbrdrb\brdrs\brdrcf1\clvertalb\cellx8436\clvertalb\cellx8620\clbrdrb\brdrs\brdrcf1\clvertalb\cellx8876\clbrdrb\brdrs\brdrcf1\clvertalb\cellx9833\clvertalb\cellx9936\trrh248\row}}}
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx4319\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4503\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4695\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5642\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5826\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6082\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7039\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7223\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7479\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8436\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8620\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8876\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9833\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9936\trrh248
\pard\plain\intbl\li660\fi-220\cf1\f51\fs20\ql Total liabilities\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr 3,448\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr \u8212?\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr \u8212?\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr 3,448\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx4319\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4503\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4695\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5642\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5826\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6082\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7039\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7223\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7479\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8436\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8620\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8876\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9833\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9936\trrh248\row}}}\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi638\cf1\f51\fs20\ql Cash equivalents of $21,709 and $16,284 as of March\~31, 2019 and December\~31, 2018, respectively, consisted of\plain\cf1\f51\fs20\ql overnight investments and money market funds and are classified within Level\~1 of the fair value hierarchy because they are\plain\cf1\f51\fs20\ql valued using quoted market prices in active markets.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi638\cf1\f51\fs20\ql The carrying value of the research and development incentive receivable, accounts payable and accrued liabilities\plain\cf1\f51\fs20\ql approximate their fair value due to the short-term nature of these assets and liabilities.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi638\cf1\f51\fs20\ql A roll-forward of the recurring fair value measurements of the warrant liability categorized with Level\~3 inputs is as\plain\cf1\f51\fs20\ql follows (in thousands):\par\pard\plain\cf1\f51\fs20\ql \~
\par\pard\plain
{\trowd\clvertalb\cellx6402\clvertalb\cellx6549\clbrdrb\brdrs\brdrcf1\clvertalb\cellx7796\clvertalb\cellx7884\trrh396
\pard\plain\intbl\cf1\f51\fs2\b\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs16\b\qc Warrant
\par\pard\plain\intbl\fs16\pard\plain\intbl\cf1\f51\fs16\b\qc Liability\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell{
{\trowd\clvertalb\cellx6402\clvertalb\cellx6549\clbrdrb\brdrs\brdrcf1\clvertalb\cellx7796\clvertalb\cellx7884\trrh396\row}}}
{\trowd\cellx6402\clvertalb\cellx6549\clvertalb\cellx7796\clvertalb\cellx7884\trrh248
\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell{
{\trowd\cellx6402\clvertalb\cellx6549\clvertalb\cellx7796\clvertalb\cellx7884\trrh248\row}}}
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx6402\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6549\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6882\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7796\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7884\trrh248
\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\b\ql Balance\u8212?December\~31, 2017\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr 11,862\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx6402\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6549\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6882\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7796\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7884\trrh248\row}}}
{\trowd\cellx6402\clvertalb\cellx6549\clbrdrb\brdrs\brdrcf1\clvertalb\cellx7796\clvertalb\cellx7884\trrh248
\pard\plain\intbl\li440\fi-220\cf1\f51\fs20\ql Change in fair value\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 4,851\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\cellx6402\clvertalb\cellx6549\clbrdrb\brdrs\brdrcf1\clvertalb\cellx7796\clvertalb\cellx7884\trrh248\row}}}
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx6402\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6549\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7796\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7884\trrh248
\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\b\ql Balance\u8212?March\~31, 2018\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 16,713\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx6402\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6549\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7796\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7884\trrh248\row}}}
{\trowd\cellx6402\clvertalb\cellx6549\clvertalb\cellx7796\clvertalb\cellx7884\trrh248
\pard\plain\intbl\li440\fi-220\cf1\f51\fs20\ql Exercise of warrants\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr (1,130\cell\pard\plain\intbl\cf1\f51\fs20\ql )\cell{
{\trowd\cellx6402\clvertalb\cellx6549\clvertalb\cellx7796\clvertalb\cellx7884\trrh248\row}}}
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx6402\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6549\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7796\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7884\trrh248
\pard\plain\intbl\li440\fi-220\cf1\f51\fs20\ql Change in Fair value\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 662\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx6402\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6549\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7796\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7884\trrh248\row}}}
{\trowd\cellx6402\clvertalb\cellx6549\clvertalb\cellx7796\clvertalb\cellx7884\trrh248
\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\b\ql Balance\u8212?June\~30, 2018\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 16,245\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\cellx6402\clvertalb\cellx6549\clvertalb\cellx7796\clvertalb\cellx7884\trrh248\row}}}
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx6402\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6549\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7796\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7884\trrh248
\pard\plain\intbl\li440\fi-220\cf1\f51\fs20\ql Change in Fair value\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr (1,793\cell\pard\plain\intbl\cf1\f51\fs20\ql )\cell{
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx6402\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6549\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7796\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7884\trrh248\row}}}
{\trowd\cellx6402\clvertalb\cellx6549\clvertalb\cellx7796\clvertalb\cellx7884\trrh248
\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\b\ql Balance\u8212?September\~30, 2018\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 14,452\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\cellx6402\clvertalb\cellx6549\clvertalb\cellx7796\clvertalb\cellx7884\trrh248\row}}}
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx6402\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6549\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7796\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7884\trrh248
\pard\plain\intbl\li440\fi-220\cf1\f51\fs20\ql Change in Fair value\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr (11,004\cell\pard\plain\intbl\cf1\f51\fs20\ql )\cell{
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{\trowd\cellx6402\clvertalb\cellx6549\clvertalb\cellx7796\clvertalb\cellx7884\trrh248
\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\b\ql Balance\u8212?December\~31, 2018\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 3,448\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\cellx6402\clvertalb\cellx6549\clvertalb\cellx7796\clvertalb\cellx7884\trrh248\row}}}
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx6402\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6549\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7796\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7884\trrh495
\pard\plain\intbl\li440\fi-220\cf1\f51\fs20\ql Final remeasurement and reclassification of 2017 Warrants to equity in\plain\intbl\li440\cf1\f51\fs20\ql connection with the adoption of ASU 2017-11\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr (3,448\cell\pard\plain\intbl\cf1\f51\fs20\ql )\cell{
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx6402\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6549\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7796\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7884\trrh495\row}}}
{\trowd\cellx6402\clvertalb\cellx6549\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx6882\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx7796\clvertalb\cellx7884\trrh248
\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\b\ql Balance\u8212?March\~31, 2019\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr \u8212?\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\cellx6402\clvertalb\cellx6549\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx6882\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx7796\clvertalb\cellx7884\trrh248\row}}}\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi638\cf1\f51\fs20\ql The warrant liability in the table above is composed of the fair value of warrants (\u8220?2017 Warrants\u8221?) to\plain\cf1\f51\fs20\ql purchase common shares that the Company issued in connection with the private placement (\u8220?Private Placement\u8221?)\plain\cf1\f51\fs20\ql of common stock in November\~2017. The fair value of the warrant liability was determined based on significant inputs not\plain\cf1\f51\fs20\ql observable in the market, which represents a Level\~3 measurement within the fair value hierarchy. The Company utilized a Monte\plain\cf1\f51\fs20\ql Carlo simulation, which is a statistical method\par\pard\plain\fi638\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\qc 13{\*\bkmkstart pb_13_021223_5796_12906402}{\*\bkmkend pb_13_021223_5796_12906402}\par\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par
\page\pard\plain\ul{\field{\*\fldinst HYPERLINK \\l "tableofcontents_12906402" }{\*\fldrslt\cf3\f51\fs20\ql Table of Contents}}\par\pard\plain\fi638\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\ql used to generate a defined number of share price paths to develop a reasonable estimate of the range of the future expected share\plain\cf1\f51\fs20\ql prices, to value the warrant liability. The Monte Carlo simulation incorporated assumptions and estimates to value the warrant\plain\cf1\f51\fs20\ql liability. Estimates and assumptions impacting the fair value measurement included the estimated probability of adjusting the\plain\cf1\f51\fs20\ql exercise price of the warrants, the number of shares for which the warrants will be exercisable, the remaining contractual term of\plain\cf1\f51\fs20\ql the warrants, the risk-free interest rate, the expected dividend yield, and the expected volatility of the price of the underlying\plain\cf1\f51\fs20\ql common shares.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi638\cf1\f51\fs20\ql The Company historically had been a private company and lacks company-specific historical and implied volatility\plain\cf1\f51\fs20\ql information of its shares. Therefore, it estimated its expected share volatility based on the historical volatility of publicly traded\plain\cf1\f51\fs20\ql peer companies for a term equal to the remaining contractual term of the warrants. The risk-free interest rate was determined by\plain\cf1\f51\fs20\ql reference to the U.S. Treasury yield curve for time periods approximately equal to the remaining contractual term of the warrants.\plain\cf1\f51\fs20\ql The Company estimated a 0% expected dividend yield based on the fact that the Company has never paid or declared dividends\plain\cf1\f51\fs20\ql and does not intend to do so in the foreseeable future.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\i\ql Leases\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi638\cf1\f51\fs20\ql In February\~2016, the FASB issued ASU 2016-02,\plain\cf1\f51\fs20\i\ql Leases,\plain\cf1\f51\fs20\ql or ASU 2016-02, to enhance the transparency and\plain\cf1\f51\fs20\ql comparability of financial reporting related to leasing arrangements. The Company adopted ASU 2016-02 on January\~1, 2019, or\plain\cf1\f51\fs20\ql the effective date, and used the effective date as its date of initial application.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi638\cf1\f51\fs20\ql At the inception of an arrangement, the Company determines whether the arrangement is or contains a lease based on the\plain\cf1\f51\fs20\ql unique facts and circumstances present. Most leases with a term greater than one year are recognized on the balance sheet as\plain\cf1\f51\fs20\ql right-of-use assets, lease liabilities and, if applicable, long-term lease liabilities. The Company has elected not to recognize on\plain\cf1\f51\fs20\ql the balance sheet leases with terms of one year or less. Operating lease liabilities and their corresponding right-of-use assets are\plain\cf1\f51\fs20\ql recorded based on the present value of lease payments over the expected remaining lease term. The Company has determined that\plain\cf1\f51\fs20\ql the rate implicit in the lease is not determinable and the Company does not have borrowings with similar terms and collateral.\plain\cf1\f51\fs20\ql Therefore, the Company considered a variety of factors, including observable debt yields from comparable companies and the\plain\cf1\f51\fs20\ql volatility in the debt market for securities with similar terms, in determining that 8% was reasonable to use as the incremental\plain\cf1\f51\fs20\ql borrowing rate for purposes of the calculation of lease liabilities.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi638\cf1\f51\fs20\ql In accordance with the guidance in ASU 2016-02, components of a lease should be split into three categories: lease\plain\cf1\f51\fs20\ql components (e.g. land, building,\~etc.), non-lease components (e.g. common area maintenance, maintenance, consumables,\~etc.),\plain\cf1\f51\fs20\ql and non-components (e.g. property taxes, insurance,\~etc.). Then the fixed and in-substance fixed contract consideration (including\plain\cf1\f51\fs20\ql any related to non-components) must be allocated based on fair values to the lease components and non-lease components.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi638\cf1\f51\fs20\ql Although separation of lease and non-lease components is required, certain practical expedients are available. Entities may\plain\cf1\f51\fs20\ql elect the practical expedient to not separate lease and non-lease components. Rather, they would account for each lease\plain\cf1\f51\fs20\ql component and the related non-lease component together as a single component. The Company has elected to account for the\plain\cf1\f51\fs20\ql lease and non-lease\par\pard\plain\fi638\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\qc 14{\*\bkmkstart pb_14_021325_2897_12906402}{\*\bkmkend pb_14_021325_2897_12906402}\par\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par
\page\pard\plain\ul{\field{\*\fldinst HYPERLINK \\l "tableofcontents_12906402" }{\*\fldrslt\cf3\f51\fs20\ql Table of Contents}}\par\pard\plain\fi638\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\ql components of each of its operating leases as a single lease component and allocate all of the contract consideration to the lease\plain\cf1\f51\fs20\ql component only. The lease component results in an operating right-of-use asset being recorded on the consolidated balance\plain\cf1\f51\fs20\ql sheets and amortized such that lease expense is recorded on a straight line basis over the term of the lease.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\i\ql Net Loss per Share\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi616\cf1\f51\fs20\ql Basic net loss per share is computed using the weighted average number of common shares outstanding during the period.\plain\cf1\f51\fs20\ql Diluted net loss per share is computed using the weighted average number of common shares outstanding during the period and,\plain\cf1\f51\fs20\ql if dilutive, the weighted average number of potential shares of common stock, including the assumed exercise of stock options\plain\cf1\f51\fs20\ql and warrants.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\i\ql Warrant Liability\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi638\cf1\f51\fs20\ql In connection with entering into the Private Placement, the Company issued the 2017 Warrants to purchase common stock\plain\cf1\f51\fs20\ql with each share of common stock sold in the Private Placement. The Company classified the 2017 Warrants as a liability on its\plain\cf1\f51\fs20\ql consolidated balance sheet prior to January\~1, 2019, because each warrant represented a freestanding financial instrument that is\plain\cf1\f51\fs20\ql not indexed to the Company\u8217?s own shares. The warrant liability was initially recorded at fair value upon entering into the\plain\cf1\f51\fs20\ql Private Placement agreement and was subsequently remeasured to fair value at each reporting date. Changes in the fair value of\plain\cf1\f51\fs20\ql the warrant liability were recognized as gains (losses) in the condensed consolidated statement of operations through the year\plain\cf1\f51\fs20\ql ended December\~31, 2018.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi638\cf1\f51\fs20\ql On January\~1, 2019, the Company adopted ASU\~No.\~2017-11, and concluded that the 2017 Warrants qualify for equity\plain\cf1\f51\fs20\ql classification.\~ The Company applied the guidance to the 2017 Warrants by means of a cumulative-effect adjustment to its\plain\cf1\f51\fs20\ql statement of financial position as of the beginning of the interim and annual period beginning January\~1, 2019.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\qc 15{\*\bkmkstart pb_15_021407_3020_12906402}{\*\bkmkend pb_15_021407_3020_12906402}\par\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par
\page\pard\plain\ul{\field{\*\fldinst HYPERLINK \\l "tableofcontents_12906402" }{\*\fldrslt\cf3\f51\fs20\ql Table of Contents}}\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\i\ql Subsequent Events\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi594\cf1\f51\fs20\ql The Company considers events or transactions that occur after the balance sheet date but prior to the issuance of the\plain\cf1\f51\fs20\ql financial statements to provide additional evidence for certain estimates or to identify matters that require additional disclosure.\plain\cf1\f51\fs20\ql Subsequent events have been evaluated as required.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\i\ql Recent Accounting Pronouncements\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi594\cf1\f51\fs20\ql From time to time, new accounting pronouncements are issued by the Financial Accounting Standards Board, or FASB,\plain\cf1\f51\fs20\ql and are early adopted by the Company or adopted as of the specified effective date.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi594\cf1\f51\fs20\ql In June\~2018, the FASB issued ASU No.\~2018-07, Compensation\u8212?Stock Compensation (Topic 718): Improvements\plain\cf1\f51\fs20\ql to Nonemployee Share-Based Payment Accounting, which is intended to simplify the accounting for share-based payments to\plain\cf1\f51\fs20\ql nonemployees by aligning it with the accounting for share-based payments to employees, with certain exceptions.\~ The Company\plain\cf1\f51\fs20\ql adopted this standard effective January\~1, 2019, which had no impact on the Company\u8217?s condensed consolidated financial\plain\cf1\f51\fs20\ql statements.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\qc 16{\*\bkmkstart pb_16_021521_376_12906402}{\*\bkmkend pb_16_021521_376_12906402}\par\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par
\page\pard\plain\ul{\field{\*\fldinst HYPERLINK \\l "tableofcontents_12906402" }{\*\fldrslt\cf3\f51\fs20\ql Table of Contents}}\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\ql 3. Accrued Expenses\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi616\cf1\f51\fs20\ql Accrued expenses consist of the following:\par\pard\plain\cf1\f51\fs20\ql \~
\par\pard\plain
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\pard\plain\intbl\cf1\f51\fs2\b\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs16\b\qc March\~31,\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs16\b\qc December\~31,\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell{
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\pard\plain\intbl\cf1\f51\fs2\b\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs16\b\qc 2019\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs16\b\qc 2018\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell{
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\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell{
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\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\ql Clinical trials\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr 3,597\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr 1,745\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
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\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\ql Professional fees\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 373\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 219\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
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{\trowd\clshdng100\clcfpat11\clcbpat11\cellx4274\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4403\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5607\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5736\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7056\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7128\trrh248
\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\ql Payroll and related expenses\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 180\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 908\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx4274\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4403\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5607\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5736\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7056\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7128\trrh248\row}}}
{\trowd\cellx4274\clvertalb\cellx4403\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx4764\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx5606\clvertalb\cellx5735\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx6211\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx7055\clvertalb\cellx7128\trrh248
\pard\plain\intbl\li440\fi-220\cf1\f51\fs20\ql Accrued expenses\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr 4,150\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr 2,872\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\cellx4274\clvertalb\cellx4403\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx4764\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx5606\clvertalb\cellx5735\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx6211\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx7055\clvertalb\cellx7128\trrh248\row}}}\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\ql 4. Leases\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi638\cf1\f51\fs20\ql In February\~2016, the FASB issued ASU 2016-02, Leases, or ASU 2016-02. ASU 2016-02 requires a lessee to recognize\plain\cf1\f51\fs20\ql on its balance sheet (for both finance and operating leases) a liability to make lease payments and a right-of-use asset\plain\cf1\f51\fs20\ql representing its right to use the underlying asset for the lease term. ASU 2016-02 is effective for fiscal years, and interim\plain\cf1\f51\fs20\ql periods within those fiscal years, beginning after December\~15, 2018. The Company adopted ASU 2016-02 on January\~1, 2019,\plain\cf1\f51\fs20\ql or the effective date, and used the effective date as its date of initial application. As such, the Company did not adjust prior\plain\cf1\f51\fs20\ql period amounts. The Company also elected to adopt the practical expedients upon transition, which permit companies to not\plain\cf1\f51\fs20\ql reassess lease identification, classification, and initial direct costs under ASU 2016-02 for leases that commenced prior to the\plain\cf1\f51\fs20\ql effective date.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi638\cf1\f51\fs20\ql The Company has operating leases for real estate in the United States and does not have any finance leases.\~ The\plain\cf1\f51\fs20\ql Company\u8217?s leases may contain options to renew and extend lease terms and options to terminate leases early. Reflected in\plain\cf1\f51\fs20\ql the right-of-use asset and lease liability on the Company\u8217?s consolidated balance sheets are the periods provided by\plain\cf1\f51\fs20\ql renewal and extension options that the Company is reasonably certain to exercise, as well as the periods provided by termination\plain\cf1\f51\fs20\ql options that the Company is reasonably certain to not exercise.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi638\cf1\f51\fs20\ql The Company has existing leases that include variable lease and non-lease components that are not included in the\plain\cf1\f51\fs20\ql right-of-use asset and lease liability and are reflected as an expense in the period incurred. Such payments primarily include\plain\cf1\f51\fs20\ql common area maintenance charges and increases in rent payments that are driven by factors such as future changes in an index\plain\cf1\f51\fs20\ql (e.g., the Consumer Price Index).\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi638\cf1\f51\fs20\ql In calculating the present value of future lease payments, the Company utilized its incremental borrowing rate based on\plain\cf1\f51\fs20\ql the remaining lease term at the date of adoption. The Company has elected to account for each lease component and its\plain\cf1\f51\fs20\ql associated non-lease components as a single lease component and has allocated all of the contract consideration across lease\plain\cf1\f51\fs20\ql components only. This will potentially result in the initial and subsequent measurement of the balances of the right-of-use asset\plain\cf1\f51\fs20\ql and lease liability for leases being greater than if the policy election was not applied. The Company has existing net leases in\plain\cf1\f51\fs20\ql which the non-lease components (e.g. common area maintenance, maintenance, consumables,\~etc.) are paid separately from rent\plain\cf1\f51\fs20\ql based on actual costs incurred and therefore are not included in the right-of-use asset and lease liability and are reflected as an\plain\cf1\f51\fs20\ql expense in the period incurred. On January 1, 2019, the Company recorded a right-of-use asset of $1,755 and a lease liability of\plain\cf1\f51\fs20\ql $1,720 on its consolidated balance sheets and reclassified a rent liability against the right-of-use asset of $35. As of March\~31,\plain\cf1\f51\fs20\ql 2019, a right-of-use asset of $1,578 and lease liability of $1,571 are reflected on the consolidated balance sheets. During the\plain\cf1\f51\fs20\ql three months ended March 31, 2019 and 2018, the Company recorded rent expense of $209 and $180, respectively.\par\pard\plain\fi638\cf1\f51\fs20\ql \~\par\pard\plain\fi638\cf1\f51\fs20\ql Future lease payments under non-cancelable leases as of March\~31, 2019 are detailed as follows:\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\qc Future\~Operating\~Lease\~Payments\par\pard\plain\cf1\f51\fs20\ql \~
\par\pard\plain
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\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\ql 2019\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr 621\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\trqc\clshdng100\clcfpat11\clcbpat11\cellx3739\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx3972\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4107\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4880\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4968\trrh248\row}}}
{\trowd\trqc\cellx3739\clvertalb\cellx3972\clvertalb\cellx4880\clvertalb\cellx4968\trrh248
\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\ql 2020\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 532\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\trqc\cellx3739\clvertalb\cellx3972\clvertalb\cellx4880\clvertalb\cellx4968\trrh248\row}}}
{\trowd\trqc\clshdng100\clcfpat11\clcbpat11\cellx3739\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx3972\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4880\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4968\trrh248
\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\ql 2021\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 434\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\trqc\clshdng100\clcfpat11\clcbpat11\cellx3739\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx3972\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4880\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4968\trrh248\row}}}
{\trowd\trqc\cellx3739\clvertalb\cellx3972\clbrdrb\brdrs\brdrcf1\clvertalb\cellx4880\clvertalb\cellx4968\trrh248
\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\ql 2022\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 146\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\trqc\cellx3739\clvertalb\cellx3972\clbrdrb\brdrs\brdrcf1\clvertalb\cellx4880\clvertalb\cellx4968\trrh248\row}}}
{\trowd\trqc\clshdng100\clcfpat11\clcbpat11\cellx3739\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx3972\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4880\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4968\trrh248
\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\b\ql Total Lease Payments\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\b\qr 1,733\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\trqc\clshdng100\clcfpat11\clcbpat11\cellx3739\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx3972\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4880\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4968\trrh248\row}}}
{\trowd\trqc\cellx3739\clvertalb\cellx3972\clbrdrb\brdrs\brdrcf1\clvertalb\cellx4880\clvertalb\cellx4968\trrh248
\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\ql Less: imputed interest\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr (162\cell\pard\plain\intbl\cf1\f51\fs20\ql )\cell{
{\trowd\trqc\cellx3739\clvertalb\cellx3972\clbrdrb\brdrs\brdrcf1\clvertalb\cellx4880\clvertalb\cellx4968\trrh248\row}}}
{\trowd\trqc\clshdng100\clcfpat11\clcbpat11\cellx3739\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx3972\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4107\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4880\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4968\trrh248
\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\b\ql Total operating lease liabilities\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\b\ql $\cell\pard\plain\intbl\cf1\f51\fs20\b\qr 1,571\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\trqc\clshdng100\clcfpat11\clcbpat11\cellx3739\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx3972\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4107\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4880\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4968\trrh248\row}}}\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\qc 17{\*\bkmkstart pb_17_021915_7748_12906402}{\*\bkmkend pb_17_021915_7748_12906402}\par\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par
\page\pard\plain\ul{\field{\*\fldinst HYPERLINK \\l "tableofcontents_12906402" }{\*\fldrslt\cf3\f51\fs20\ql Table of Contents}}\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\ql 5. Warrants\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi638\cf1\f51\fs20\ql As of March\~31, 2019, outstanding warrants to purchase common stock consisted of the following:\par\pard\plain\cf1\f51\fs20\ql \~
\par\pard\plain
{\trowd\clbrdrb\brdrs\brdrcf1\clvertalb\cellx7814\clvertalb\cellx7884\trrh198
\pard\plain\intbl\li220\fi-220\cf1\f51\fs16\b\qc March\~31,\~2019\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell{
{\trowd\clbrdrb\brdrs\brdrcf1\clvertalb\cellx7814\clvertalb\cellx7884\trrh198\row}}}
{\trowd\clbrdrb\brdrs\brdrcf1\clvertalb\cellx1807\clvertalb\cellx1959\clbrdrb\brdrs\brdrcf1\clvertalb\cellx3352\clvertalb\cellx3504\clbrdrb\brdrs\brdrcf1\clvertalb\cellx4806\clvertalb\cellx4958\clbrdrb\brdrs\brdrcf1\clvertalb\cellx6316\clvertalb\cellx6468\clbrdrb\brdrs\brdrcf1\clvertalb\cellx7808\clvertalb\cellx7884\trrh396
\pard\plain\intbl\cf1\f51\fs16\b\ql Date\~Exercisable\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs16\b\qc Number\~of\~Shares
\par\pard\plain\intbl\fs16\pard\plain\intbl\cf1\f51\fs16\b\qc Issuable\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs16\b\qc Exercise\~Price\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs16\b\qc Exercisable\~for\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs16\b\qc Classification\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell{
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{\trowd\cellx1807\clvertalb\cellx1959\clvertalb\cellx3352\clvertalb\cellx3504\clvertalb\cellx4806\clvertalb\cellx4958\clvertalb\cellx6316\clvertalb\cellx6468\clvertalb\cellx7808\clvertalb\cellx7884\trrh248
\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell{
{\trowd\cellx1807\clvertalb\cellx1959\clvertalb\cellx3352\clvertalb\cellx3504\clvertalb\cellx4806\clvertalb\cellx4958\clvertalb\cellx6316\clvertalb\cellx6468\clvertalb\cellx7808\clvertalb\cellx7884\trrh248\row}}}
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx1807\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx1959\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx3352\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx3504\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4000\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4805\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4957\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6315\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6467\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7807\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7884\trrh248
\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\qc 1/23/2017\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 54,516\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr 0.01\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql Common Stock\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql Equity\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx1807\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx1959\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx3352\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx3504\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4000\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4805\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4957\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6315\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6467\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7807\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7884\trrh248\row}}}
{\trowd\cellx1807\clvertalb\cellx1959\clvertalb\cellx3352\clvertalb\cellx3504\clvertalb\cellx4000\clvertalb\cellx4805\clvertalb\cellx4957\clvertalb\cellx6315\clvertalb\cellx6467\clvertalb\cellx7807\clvertalb\cellx7884\trrh248
\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\qc 11/14/2017\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 2,758,094\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr 1.75\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql Common Stock\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql Equity\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\cellx1807\clvertalb\cellx1959\clvertalb\cellx3352\clvertalb\cellx3504\clvertalb\cellx4000\clvertalb\cellx4805\clvertalb\cellx4957\clvertalb\cellx6315\clvertalb\cellx6467\clvertalb\cellx7807\clvertalb\cellx7884\trrh248\row}}}
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx1807\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx1959\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx3352\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx3504\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4000\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4805\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4957\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6315\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6467\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7807\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7884\trrh248
\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\qc 2/5/2019\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 7,557,142\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr 1.95\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql Common Stock\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql Equity\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
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\pard\plain\intbl\li220\fi-220\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 10,369,752\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\qr \~\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\qr \~\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\qr \~\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\cellx1807\clvertalb\cellx1959\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx3352\clvertalb\cellx3504\clvertalb\cellx4806\clvertalb\cellx4958\clvertalb\cellx6316\clvertalb\cellx6468\clvertalb\cellx7808\clvertalb\cellx7884\trrh248\row}}}\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\i\ul\ql 2017 Warrants\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi638\cf1\f51\fs20\ql The 2017 Warrants contain full ratchet anti-dilution protection provisions. Prior to January\~1, 2019, the Company\plain\cf1\f51\fs20\ql classified the 2017 Warrants as a liability on its consolidated balance sheet because each warrant represented a freestanding\plain\cf1\f51\fs20\ql financial instrument that, due to the potential variable nature of the exercise price, is not considered to be indexed to the\plain\cf1\f51\fs20\ql Company\u8217?s own shares. The warrant liability was initially recorded at fair value upon entering into the Private Placement\plain\cf1\f51\fs20\ql and has been subsequently remeasured to fair value at each reporting date. Changes in the fair value of the warrant liability were\plain\cf1\f51\fs20\ql recognized as gains (losses) in the Company\u8217?s consolidated statement of operations.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi638\cf1\f51\fs20\ql On January\~1, 2019, the Company adopted ASU 2017-11 and concluded that the 2017 Warrants now qualify for equity\plain\cf1\f51\fs20\ql classification.\~ The Company applied the guidance retrospectively to the 2017 Warrants by means of a cumulative-effect\plain\cf1\f51\fs20\ql adjustment to its statement of financial position as of the beginning of the interim and annual period beginning January\~1, 2019.\~\plain\cf1\f51\fs20\ql The Company performed a final remeasurement of the warrant liability as of January\~1, 2019 and reclassified $3,448 to additional\plain\cf1\f51\fs20\ql paid in capital.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi638\cf1\f51\fs20\ql The Company will recognize on a prospective basis the value of the effect of the down round feature in the warrant when\plain\cf1\f51\fs20\ql it is triggered (i.e., when the exercise price is adjusted downward). This value is measured as the difference between (1)\~the\plain\cf1\f51\fs20\ql financial instrument\u8217?s fair value (without the down round feature) using the pre-trigger exercise price and (2)\~the financial\plain\cf1\f51\fs20\ql instrument\u8217?s fair value (with the down round feature) using the reduced exercise price. The value of the effect of the down\plain\cf1\f51\fs20\ql round feature will be treated as a dividend and a reduction to income available to common shareholders in the basic EPS\plain\cf1\f51\fs20\ql calculation.\~ In connection with the public offering in February\~2019, when the 2017 Warrants were repriced from $6.085 to\plain\cf1\f51\fs20\ql $1.75, the Company recorded a dividend of $359 during the three months ended March\~31, 2019.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\i\ul\ql 2019 Warrants\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi638\cf1\f51\fs20\ql On February\~5, 2019, in connection with the 2019 Public Offering the Company issued immediately exercisable warrants\plain\cf1\f51\fs20\ql (\u8220?2019 Warrants\u8221?) to purchase 7,557,142 shares of common stock to investors. The 2019 Warrants have an exercise\plain\cf1\f51\fs20\ql price of $1.95 per share and expire on February\~5, 2026.\~ The 2019 Warrants qualify for equity classification.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\ql 6. Common Stock\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi638\cf1\f51\fs20\ql Each share of common stock entitles the holder to one vote on all matters submitted to a vote of the Company\u8217?s\plain\cf1\f51\fs20\ql stockholders. Common stockholders are entitled to receive dividends, as may be declared by the board of directors, if any, subject\plain\cf1\f51\fs20\ql to the preferential dividend rights of the preferred stockholders. Through March\~31, 2019 no dividends have been declared.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\qc 18{\*\bkmkstart pb_18_022837_141_12906402}{\*\bkmkend pb_18_022837_141_12906402}\par\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par
\page\pard\plain\ul{\field{\*\fldinst HYPERLINK \\l "tableofcontents_12906402" }{\*\fldrslt\cf3\f51\fs20\ql Table of Contents}}\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\i\ql Public Offering of Common Stock \u8212? March\~2018\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi638\cf1\f51\fs20\ql On March\~27, 2018, the Company completed a public offering whereby the Company issued 2,146,667 shares of its\plain\cf1\f51\fs20\ql common stock at a price of $7.50 per share, which included 280,000 shares issued pursuant to the underwriters\u8217? exercise\plain\cf1\f51\fs20\ql of their option to purchase additional shares of common stock. The aggregate net proceeds received by the Company from the\plain\cf1\f51\fs20\ql offering were approximately $14,796, net of underwriting discounts and commissions and estimated offering expenses payable by\plain\cf1\f51\fs20\ql the Company.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\i\ql Public Offering of Common Stock \u8212? February\~2019\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi638\cf1\f51\fs20\ql On February\~5, 2019, the Company completed the 2019 Public Offering whereby the Company issued 7,557,142 shares of\plain\cf1\f51\fs20\ql its common stock at a price of $1.75 per share, which included 985,714 shares issued pursuant to the underwriters\u8217?\plain\cf1\f51\fs20\ql exercise of their option to purchase additional shares of common stock, each share issued with a warrant to purchase one share of\plain\cf1\f51\fs20\ql common stock. Each warrant has an exercise price of $1.95 per share with an exercise period expiring seven years from the date\plain\cf1\f51\fs20\ql of issuance. The aggregate net proceeds received by the Company from the 2019 Public Offering were approximately $12,122,\plain\cf1\f51\fs20\ql net of underwriting discounts and commissions and estimated offering expenses payable by the Company.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\qc 19{\*\bkmkstart pb_19_022845_7608_12906402}{\*\bkmkend pb_19_022845_7608_12906402}\par\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par
\page\pard\plain\ul{\field{\*\fldinst HYPERLINK \\l "tableofcontents_12906402" }{\*\fldrslt\cf3\f51\fs20\ql Table of Contents}}\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\ql 7. Equity Incentive Plans\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\i\ql Equity Incentive Plans\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi352\cf1\f51\fs20\ql In September\~2012, the Company adopted the 2012 Equity Incentive Plan, as amended (the \u8220?Plan\u8221?), which\plain\cf1\f51\fs20\ql provides designated employees of the Company and its affiliates, certain consultants and advisors who perform services for the\plain\cf1\f51\fs20\ql Company and its affiliates, and nonemployee members of the Board of Directors of the Company and its affiliates with the\plain\cf1\f51\fs20\ql opportunity to receive grants of incentive stock options, nonqualified stock options and stock awards. On January\~20, 2017, the\plain\cf1\f51\fs20\ql Company\u8217?s stockholders approved the amended and restated 2012 Equity Incentive Plan (the \u8220?2012 Plan\u8221?),\plain\cf1\f51\fs20\ql which amended and restated the Plan and was effective in connection with the completion of the Company\u8217?s merger with\plain\cf1\f51\fs20\ql Macrocure.\~ As of March\~31, 2019, there were 1,379,018 outstanding options issued under the 2012 Plan.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi352\cf1\f51\fs20\ql On January\~20, 2017, the Company\u8217?s stockholders approved the 2016 Equity Incentive Plan (the \u8220?2016\plain\cf1\f51\fs20\ql Plan\u8221?), which was effective in connection with the completion of the Company\u8217?s merger with Macrocure. The\plain\cf1\f51\fs20\ql number of shares of common stock issuable pursuant to outstanding awards granted under the 2016 Plan may not exceed the\plain\cf1\f51\fs20\ql number that is equal to the sum of (i)\~854,321 shares of common stock plus (ii)\~the number of shares of common stock (not to\plain\cf1\f51\fs20\ql exceed 103,023 shares) subject to out-of-the-money options issued by Macrocure prior to the closing of the merger and assumed\plain\cf1\f51\fs20\ql by the Company pursuant to the merger agreement upon consummation of the merger that expire unexercised. Beginning on\plain\cf1\f51\fs20\ql January\~1, 2018, the number of shares of common stock authorized for issuance pursuant to the 2016 Plan was increased each\plain\cf1\f51\fs20\ql January\~1 by an amount equal to four percent (4%) of the Company\u8217?s outstanding common stock as of the end of the\plain\cf1\f51\fs20\ql immediately preceding calendar year or such other amount as determined by the compensation committee of the\plain\cf1\f51\fs20\ql Company\u8217?s Board of Directors. As of March\~31, 2019, there were 1,310,612 outstanding options issued under the 2016\plain\cf1\f51\fs20\ql Plan.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi352\cf1\f51\fs20\ql In connection with the merger with Macrocure in January\~2017, the Company assumed the Macrocure 2013 Share Incentive\plain\cf1\f51\fs20\ql Plan (the \u8220?2013 Plan\u8221?), the Macrocure 2008 Stock Option Plan (the \u8220?2008 Plan\u8221?) and all stock options\plain\cf1\f51\fs20\ql outstanding under each of the 2013 Plan and the 2008 Plan immediately prior to the consummation of the merger.\~ By virtue of\plain\cf1\f51\fs20\ql the terms of the Merger Agreement and the 2013 Plan or the 2008 Plan, as applicable, each stock option outstanding immediately\plain\cf1\f51\fs20\ql prior to the consummation of the merger was automatically converted into a stock option exercisable for a number of shares of\plain\cf1\f51\fs20\ql the Company\u8217?s common stock calculated based on the exchange ratio and the exercise price per share of such outstanding\plain\cf1\f51\fs20\ql stock option.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi352\cf1\f51\fs20\ql The Company could also make awards of restricted stock under the 2016 Plan. Restricted stock may be issued under the\plain\cf1\f51\fs20\ql Equity Plan for such consideration, in cash, other property or services, or any combination thereof, as is determined by the Board\plain\cf1\f51\fs20\ql of Directors. During the restriction period applicable to the shares of restricted stock, such shares shall be subject to limitations\plain\cf1\f51\fs20\ql on transferability, subject to forfeiture or repurchase by the Company and/or subject to other terms and conditions. Upon lapse of\plain\cf1\f51\fs20\ql such restrictions, the stock certificates representing shares of common stock shall be delivered to the grantee. As of March\~31,\plain\cf1\f51\fs20\ql 2019, there were 669,105 shares available for grant under the Company\u8217?s Equity Incentive Plans.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi616\cf1\f51\fs20\ql A summary of activity under the Equity Plans is as follows:\par\pard\plain\cf1\f51\fs20\ql \~
\par\pard\plain
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\pard\plain\intbl\cf1\f51\fs2\b\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs16\b\qc Weighted\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell{
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\pard\plain\intbl\cf1\f51\fs2\b\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs16\b\qc Average\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs16\b\qc Weighted\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs16\b\qc Aggregate\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell{
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\pard\plain\intbl\cf1\f51\fs2\b\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs16\b\qc Exercise\~Price\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs16\b\qc Average\~Remaining\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs16\b\qc Intrinsic\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell{
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\pard\plain\intbl\cf1\f51\fs2\b\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs16\b\qc Options\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs16\b\qc Per\~Share\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs16\b\qc Life\~in\~Years\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs16\b\qc Value\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell{
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\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\ql Outstanding at December\~31, 2018\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 2,761,912\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr 11.30\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 8.01\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr \u8212?\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
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{\trowd\cellx3794\clvertalb\cellx3979\clvertalb\cellx5138\clvertalb\cellx5325\clvertalb\cellx5821\clvertalb\cellx6784\clvertalb\cellx6969\clvertalb\cellx8371\clvertalb\cellx8556\clvertalb\cellx9969\clvertalb\cellx10044\trrh248
\pard\plain\intbl\li440\fi-220\cf1\f51\fs20\ql Granted\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 214,475\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr 2.00\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\qr \~\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\qr \~\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\cellx3794\clvertalb\cellx3979\clvertalb\cellx5138\clvertalb\cellx5325\clvertalb\cellx5821\clvertalb\cellx6784\clvertalb\cellx6969\clvertalb\cellx8371\clvertalb\cellx8556\clvertalb\cellx9969\clvertalb\cellx10044\trrh248\row}}}
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx3794\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx3979\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5138\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5325\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5821\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6784\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6969\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8371\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8556\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9969\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10044\trrh248
\pard\plain\intbl\li440\fi-220\cf1\f51\fs20\ql Exercised\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \u8212?\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr \u8212?\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\qr \~\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\qr \~\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx3794\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx3979\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5138\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5325\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5821\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6784\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6969\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8371\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8556\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9969\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10044\trrh248\row}}}
{\trowd\cellx3794\clvertalb\cellx3979\clbrdrb\brdrs\brdrcf1\clvertalb\cellx5138\clvertalb\cellx5325\clvertalb\cellx5821\clvertalb\cellx6784\clvertalb\cellx6969\clvertalb\cellx8371\clvertalb\cellx8556\clvertalb\cellx9969\clvertalb\cellx10044\trrh248
\pard\plain\intbl\li440\fi-220\cf1\f51\fs20\ql Forfeited\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr (71,053\cell\pard\plain\intbl\cf1\f51\fs20\ql )\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr 35.10\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\qr \~\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\qr \~\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\cellx3794\clvertalb\cellx3979\clbrdrb\brdrs\brdrcf1\clvertalb\cellx5138\clvertalb\cellx5325\clvertalb\cellx5821\clvertalb\cellx6784\clvertalb\cellx6969\clvertalb\cellx8371\clvertalb\cellx8556\clvertalb\cellx9969\clvertalb\cellx10044\trrh248\row}}}
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx3794\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx3979\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5138\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5325\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5821\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6784\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6969\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8371\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8556\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8916\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9968\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10044\trrh248
\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\ql Outstanding at March\~31, 2019\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 2,905,334\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr 10.03\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 8.10\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr \u8212?\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx3794\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx3979\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5138\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5325\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5821\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6784\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6969\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8371\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8556\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8916\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9968\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10044\trrh248\row}}}
{\trowd\cellx3794\clvertalb\cellx3979\clvertalb\cellx5138\clvertalb\cellx5325\clvertalb\cellx6785\clvertalb\cellx6970\clvertalb\cellx8372\clvertalb\cellx8557\clvertalb\cellx9970\clvertalb\cellx10044\trrh248
\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell{
{\trowd\cellx3794\clvertalb\cellx3979\clvertalb\cellx5138\clvertalb\cellx5325\clvertalb\cellx6785\clvertalb\cellx6970\clvertalb\cellx8372\clvertalb\cellx8557\clvertalb\cellx9970\clvertalb\cellx10044\trrh248\row}}}
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx3794\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx3979\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5138\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5325\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5821\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6784\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6969\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8371\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8556\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8916\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9968\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10044\trrh248
\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\ql Options exercisable at March\~31, 2019\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 1,701,823\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr 12.44\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 7.59\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr \u8212?\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx3794\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx3979\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5138\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5325\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5821\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6784\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6969\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8371\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8556\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8916\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9968\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10044\trrh248\row}}}
{\trowd\cellx3794\clvertalb\cellx3979\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx5138\clvertalb\cellx5325\clvertalb\cellx5821\clvertalb\cellx6784\clvertalb\cellx6969\clvertalb\cellx8371\clvertalb\cellx8556\clvertalb\cellx8916\clvertalb\cellx9968\clvertalb\cellx10044\trrh495
\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\ql Options vested and expected to vest at\plain\intbl\li220\cf1\f51\fs20\ql March\~31, 2019\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 2,905,334\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr 10.03\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 8.10\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr \u8212?\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\cellx3794\clvertalb\cellx3979\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx5138\clvertalb\cellx5325\clvertalb\cellx5821\clvertalb\cellx6784\clvertalb\cellx6969\clvertalb\cellx8371\clvertalb\cellx8556\clvertalb\cellx8916\clvertalb\cellx9968\clvertalb\cellx10044\trrh495\row}}}\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi616\cf1\f51\fs20\ql The grant date fair value of the options granted during the year ended December\~31, 2018 and the three months ended\plain\cf1\f51\fs20\ql March\~31, 2019, was estimated at the date of grant using the Black-Scholes option valuation model. The expected life was\plain\cf1\f51\fs20\ql estimated using the \u8220?simplified\u8221? method as defined by the Securities and Exchange Commission\u8217?s Staff\plain\cf1\f51\fs20\ql Accounting Bulletin 107, Share-Based Payment. The expected volatility was based on the historical volatility of comparable\plain\cf1\f51\fs20\ql public companies from a representative peer group selected based on industry and market capitalization data. The risk-free\plain\cf1\f51\fs20\ql interest rate was based on the continuous rates provided\par\pard\plain\fi616\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\qc 20{\*\bkmkstart pb_20_023335_8146_12906402}{\*\bkmkend pb_20_023335_8146_12906402}\par\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par
\page\pard\plain\ul{\field{\*\fldinst HYPERLINK \\l "tableofcontents_12906402" }{\*\fldrslt\cf3\f51\fs20\ql Table of Contents}}\par\pard\plain\fi616\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\ql by the U.S. Treasury with a term approximating the expected life of the option. The expected dividend yield was 0% because the\plain\cf1\f51\fs20\ql Company does not expect to pay any dividends for the foreseeable future. The Company elected the straight-line attribution\plain\cf1\f51\fs20\ql method in recognizing the grant date fair value of options issued over the requisite service periods of the awards, which are\plain\cf1\f51\fs20\ql generally the vesting periods.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi616\cf1\f51\fs20\ql The assumptions that the Company used to determine the grant-date fair value of stock options granted to employees and\plain\cf1\f51\fs20\ql directors during the year ended December\~31, 2018 and the three months ended March\~31, 2019 were as follows, presented on a\plain\cf1\f51\fs20\ql weighted average basis:\par\pard\plain\cf1\f51\fs20\ql \~
\par\pard\plain
{\trowd\clvertalb\cellx4214\clvertalb\cellx4429\clvertalb\cellx5695\clvertalb\cellx5914\clvertalb\cellx7155\clvertalb\cellx7344\trrh396
\pard\plain\intbl\cf1\f51\fs2\b\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs16\b\qc Three\~Months
\par\pard\plain\intbl\fs16\pard\plain\intbl\cf1\f51\fs16\b\qc Ended\~March\~31,\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs16\b\qc Year\~Ended
\par\pard\plain\intbl\fs16\pard\plain\intbl\cf1\f51\fs16\b\qc December\~31,\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell{
{\trowd\clvertalb\cellx4214\clvertalb\cellx4429\clvertalb\cellx5695\clvertalb\cellx5914\clvertalb\cellx7155\clvertalb\cellx7344\trrh396\row}}}
{\trowd\clvertalb\cellx4214\clvertalb\cellx4429\clbrdrb\brdrs\brdrcf1\clvertalb\cellx5695\clvertalb\cellx5914\clbrdrb\brdrs\brdrcf1\clvertalb\cellx7155\clvertalb\cellx7344\trrh198
\pard\plain\intbl\cf1\f51\fs2\b\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs16\b\qc 2019\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs16\b\qc 2018\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell{
{\trowd\clvertalb\cellx4214\clvertalb\cellx4429\clbrdrb\brdrs\brdrcf1\clvertalb\cellx5695\clvertalb\cellx5914\clbrdrb\brdrs\brdrcf1\clvertalb\cellx7155\clvertalb\cellx7344\trrh198\row}}}
{\trowd\cellx4214\clvertalb\cellx4429\clvertalb\cellx5695\clvertalb\cellx5914\clvertalb\cellx7155\clvertalb\cellx7344\trrh248
\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell{
{\trowd\cellx4214\clvertalb\cellx4429\clvertalb\cellx5695\clvertalb\cellx5914\clvertalb\cellx7155\clvertalb\cellx7344\trrh248\row}}}
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx4214\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4429\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5695\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5914\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7155\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7344\trrh248
\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\ql Expected volatility\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 66.94\cell\pard\plain\intbl\cf1\f51\fs20\ql %\cell\pard\plain\intbl\cf1\f51\fs20\qr 66.94\cell\pard\plain\intbl\cf1\f51\fs20\ql %\cell{
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx4214\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4429\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5695\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5914\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7155\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7344\trrh248\row}}}
{\trowd\cellx4214\clvertalb\cellx4429\clvertalb\cellx5695\clvertalb\cellx5914\clvertalb\cellx7155\clvertalb\cellx7344\trrh248
\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\ql Weighted average risk-free interest rate\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 2.55\cell\pard\plain\intbl\cf1\f51\fs20\ql %\cell\pard\plain\intbl\cf1\f51\fs20\qr 2.80\cell\pard\plain\intbl\cf1\f51\fs20\ql %\cell{
{\trowd\cellx4214\clvertalb\cellx4429\clvertalb\cellx5695\clvertalb\cellx5914\clvertalb\cellx7155\clvertalb\cellx7344\trrh248\row}}}
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx4214\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4429\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5695\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5914\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7155\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7344\trrh248
\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\ql Expected dividend yield\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 0.00\cell\pard\plain\intbl\cf1\f51\fs20\ql %\cell\pard\plain\intbl\cf1\f51\fs20\qr 0.00\cell\pard\plain\intbl\cf1\f51\fs20\ql %\cell{
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx4214\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4429\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5695\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5914\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7155\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7344\trrh248\row}}}
{\trowd\cellx4214\clvertalb\cellx4429\clvertalb\cellx5695\clvertalb\cellx5914\clvertalb\cellx7155\clvertalb\cellx7344\trrh248
\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\ql Expected term (in years)\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 6.84\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 6.95\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\cellx4214\clvertalb\cellx4429\clvertalb\cellx5695\clvertalb\cellx5914\clvertalb\cellx7155\clvertalb\cellx7344\trrh248\row}}}\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi616\cf1\f51\fs20\ql Stock options generally vest over a three or four year period, as determined by the Compensation Committee of the Board\plain\cf1\f51\fs20\ql of Directors at the time of grant. The options expire ten years from the grant date. As of March\~31, 2019, there was\plain\cf1\f51\fs20\ql approximately $5,007 of unrecognized compensation cost related to non-vested stock options, which is expected to be recognized\plain\cf1\f51\fs20\ql over a remaining weighted-average period of approximately 2.12 years.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi616\cf1\f51\fs20\ql The Company recognized stock-based compensation expense related to the issuance of stock option awards to employees\plain\cf1\f51\fs20\ql and non-employees in the condensed consolidated statements of operations and comprehensive loss as follows:\par\pard\plain\cf1\f51\fs20\ql \~
\par\pard\plain
{\trowd\clvertalb\cellx3779\clvertalb\cellx3966\clbrdrb\brdrs\brdrcf1\clvertalb\cellx7269\clvertalb\cellx7344\trrh198
\pard\plain\intbl\cf1\f51\fs2\b\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs16\b\qc Three\~Months\~Ended\~March\~31,\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell{
{\trowd\clvertalb\cellx3779\clvertalb\cellx3966\clbrdrb\brdrs\brdrcf1\clvertalb\cellx7269\clvertalb\cellx7344\trrh198\row}}}
{\trowd\clvertalb\cellx3779\clvertalb\cellx3966\clbrdrb\brdrs\brdrcf1\clvertalb\cellx5367\clvertalb\cellx5811\clbrdrb\brdrs\brdrcf1\clvertalb\cellx7269\clvertalb\cellx7344\trrh198
\pard\plain\intbl\cf1\f51\fs2\b\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs16\b\qc 2019\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs16\b\qc 2018\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell{
{\trowd\clvertalb\cellx3779\clvertalb\cellx3966\clbrdrb\brdrs\brdrcf1\clvertalb\cellx5367\clvertalb\cellx5811\clbrdrb\brdrs\brdrcf1\clvertalb\cellx7269\clvertalb\cellx7344\trrh198\row}}}
{\trowd\cellx3779\clvertalb\cellx3966\clvertalb\cellx5367\clvertalb\cellx5811\clvertalb\cellx7269\clvertalb\cellx7344\trrh248
\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell{
{\trowd\cellx3779\clvertalb\cellx3966\clvertalb\cellx5367\clvertalb\cellx5811\clvertalb\cellx7269\clvertalb\cellx7344\trrh248\row}}}
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx3779\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx3966\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4409\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5366\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5810\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6254\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7268\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7344\trrh248
\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\ql Research and development\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr 176\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr 117\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx3779\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx3966\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4409\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5366\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5810\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6254\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7268\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7344\trrh248\row}}}
{\trowd\cellx3779\clvertalb\cellx3966\clbrdrb\brdrs\brdrcf1\clvertalb\cellx5367\clvertalb\cellx5811\clbrdrb\brdrs\brdrcf1\clvertalb\cellx7269\clvertalb\cellx7344\trrh248
\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\ql General and administrative\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 771\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 611\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\cellx3779\clvertalb\cellx3966\clbrdrb\brdrs\brdrcf1\clvertalb\cellx5367\clvertalb\cellx5811\clbrdrb\brdrs\brdrcf1\clvertalb\cellx7269\clvertalb\cellx7344\trrh248\row}}}
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx3779\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx3966\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4409\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5366\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5810\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6254\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7268\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7344\trrh248
\pard\plain\intbl\li440\fi-220\cf1\f51\fs20\ql Total\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr 947\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr 728\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx3779\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx3966\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4409\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5366\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5810\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6254\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7268\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7344\trrh248\row}}}\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\ql 8. Net Loss Per Share\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi616\cf1\f51\fs20\ql Basic and diluted net loss per share for the three months ended March\~31, 2019 and 2018 was calculated as follows (in\plain\cf1\f51\fs20\ql thousands except share and per share amounts):\par\pard\plain\cf1\f51\fs20\ql \~
\par\pard\plain
{\trowd\clvertalb\cellx6358\clvertalb\cellx6540\clbrdrb\brdrs\brdrcf1\clvertalb\cellx9943\clvertalb\cellx10044\trrh198
\pard\plain\intbl\cf1\f51\fs2\b\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs16\b\qc Three\~Months\~Ended\~March\~31,\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell{
{\trowd\clvertalb\cellx6358\clvertalb\cellx6540\clbrdrb\brdrs\brdrcf1\clvertalb\cellx9943\clvertalb\cellx10044\trrh198\row}}}
{\trowd\clvertalb\cellx6358\clvertalb\cellx6540\clbrdrb\brdrs\brdrcf1\clvertalb\cellx8011\clvertalb\cellx8455\clbrdrb\brdrs\brdrcf1\clvertalb\cellx9943\clvertalb\cellx10044\trrh198
\pard\plain\intbl\cf1\f51\fs2\b\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs16\b\qc 2019\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs16\b\qc 2018\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell{
{\trowd\clvertalb\cellx6358\clvertalb\cellx6540\clbrdrb\brdrs\brdrcf1\clvertalb\cellx8011\clvertalb\cellx8455\clbrdrb\brdrs\brdrcf1\clvertalb\cellx9943\clvertalb\cellx10044\trrh198\row}}}
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx6358\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6540\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8011\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8455\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9943\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10044\trrh248
\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\ql Numerator:\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\qr \~\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\qr \~\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx6358\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6540\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8011\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8455\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9943\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10044\trrh248\row}}}
{\trowd\cellx6358\clvertalb\cellx6540\clvertalb\cellx6984\clvertalb\cellx8011\clvertalb\cellx8455\clvertalb\cellx8899\clvertalb\cellx9943\clvertalb\cellx10044\trrh248
\pard\plain\intbl\li440\fi-220\cf1\f51\fs20\ql Net loss\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr (8,603\cell\pard\plain\intbl\cf1\f51\fs20\ql )\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr (10,622\cell\pard\plain\intbl\cf1\f51\fs20\ql )\cell{
{\trowd\cellx6358\clvertalb\cellx6540\clvertalb\cellx6984\clvertalb\cellx8011\clvertalb\cellx8455\clvertalb\cellx8899\clvertalb\cellx9943\clvertalb\cellx10044\trrh248\row}}}
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx6358\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6540\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6984\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8011\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8455\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8899\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9943\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10044\trrh248
\pard\plain\intbl\li440\fi-220\cf1\f51\fs20\ql Dividend attributable to down round feature of warrants\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr (359\cell\pard\plain\intbl\cf1\f51\fs20\ql )\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \u8212?\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx6358\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6540\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6984\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8011\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8455\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8899\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9943\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10044\trrh248\row}}}
{\trowd\cellx6358\clvertalb\cellx6540\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx6984\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx8011\clvertalb\cellx8455\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx8899\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx9943\clvertalb\cellx10044\trrh495
\pard\plain\intbl\li440\fi-220\cf1\f51\fs20\ql Net loss attributable to common stockholders for basic and diluted loss\plain\intbl\li440\cf1\f51\fs20\ql per share\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr (8,962\cell\pard\plain\intbl\cf1\f51\fs20\ql )\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr (10,622\cell\pard\plain\intbl\cf1\f51\fs20\ql )\cell{
{\trowd\cellx6358\clvertalb\cellx6540\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx6984\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx8011\clvertalb\cellx8455\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx8899\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx9943\clvertalb\cellx10044\trrh495\row}}}
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx6358\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6540\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8011\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8455\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9943\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10044\trrh248
\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell{
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx6358\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6540\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8011\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8455\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9943\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10044\trrh248\row}}}
{\trowd\cellx6358\clvertalb\cellx6540\clvertalb\cellx8011\clvertalb\cellx8455\clvertalb\cellx9943\clvertalb\cellx10044\trrh248
\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\ql Denominator:\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\qr \~\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\qr \~\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\cellx6358\clvertalb\cellx6540\clvertalb\cellx8011\clvertalb\cellx8455\clvertalb\cellx9943\clvertalb\cellx10044\trrh248\row}}}
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx6358\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6540\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8011\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8455\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9943\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10044\trrh495
\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\ql Weighted average number of common shares outstanding - basic and\plain\intbl\li220\cf1\f51\fs20\ql diluted\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 19,237,444\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 12,449,421\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx6358\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6540\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8011\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8455\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9943\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10044\trrh495\row}}}
{\trowd\cellx6358\clvertalb\cellx6540\clvertalb\cellx8011\clvertalb\cellx8455\clvertalb\cellx9943\clvertalb\cellx10044\trrh248
\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell{
{\trowd\cellx6358\clvertalb\cellx6540\clvertalb\cellx8011\clvertalb\cellx8455\clvertalb\cellx9943\clvertalb\cellx10044\trrh248\row}}}
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx6358\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6540\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6984\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8011\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8455\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8899\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9943\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10044\trrh248
\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\ql Net loss per share attributable to common stockholders - basic and diluted\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr (0.47\cell\pard\plain\intbl\cf1\f51\fs20\ql )\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr (0.85\cell\pard\plain\intbl\cf1\f51\fs20\ql )\cell{
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx6358\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6540\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6984\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8011\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8455\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8899\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9943\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10044\trrh248\row}}}\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi616\cf1\f51\fs20\ql The Company\u8217?s potentially dilutive securities include stock options and warrants. These securities were excluded\plain\cf1\f51\fs20\ql from the computations of diluted net loss per share for the three months ended March\~31, 2019 and 2018, as the effect would be\plain\cf1\f51\fs20\ql to reduce the net loss per share.\~ The following table includes the potential shares of common stock, presented based on amounts\plain\cf1\f51\fs20\ql outstanding at each period end, that were excluded from the computation of diluted net loss per share attributable to common\plain\cf1\f51\fs20\ql stockholders for the periods indicated because including them would have had an anti-dilutive effect:\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\qc 21{\*\bkmkstart pb_21_024625_7091_12906402}{\*\bkmkend pb_21_024625_7091_12906402}\par\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par
\page\pard\plain\ul{\field{\*\fldinst HYPERLINK \\l "tableofcontents_12906402" }{\*\fldrslt\cf3\f51\fs20\ql Table of Contents}}\par\pard\plain\cf1\f51\fs20\ql \~
\par\pard\plain
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\pard\plain\intbl\cf1\f51\fs2\b\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs16\b\qc Three\~Months\~Ended\~March\~31,\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell{
{\trowd\clvertalb\cellx6149\clvertalb\cellx6332\clbrdrb\brdrs\brdrcf1\clvertalb\cellx9517\clvertalb\cellx9612\trrh198\row}}}
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\pard\plain\intbl\cf1\f51\fs2\b\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs16\b\qc 2019\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs16\b\qc 2018\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell{
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\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell{
{\trowd\cellx6149\clvertalb\cellx6332\clvertalb\cellx7558\clvertalb\cellx8298\clvertalb\cellx9516\clvertalb\cellx9612\trrh248\row}}}
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\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\ql Options to purchase common stock\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 2,905,334\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 2,250,080\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx6149\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6332\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7558\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8298\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9516\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9612\trrh248\row}}}
{\trowd\cellx6149\clvertalb\cellx6332\clbrdrb\brdrs\brdrcf1\clvertalb\cellx7558\clvertalb\cellx8298\clbrdrb\brdrs\brdrcf1\clvertalb\cellx9516\clvertalb\cellx9612\trrh248
\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\ql Warrants to purchase common stock\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 10,369,752\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 3,012,610\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\cellx6149\clvertalb\cellx6332\clbrdrb\brdrs\brdrcf1\clvertalb\cellx7558\clvertalb\cellx8298\clbrdrb\brdrs\brdrcf1\clvertalb\cellx9516\clvertalb\cellx9612\trrh248\row}}}
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx6149\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6332\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7558\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8298\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9516\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9612\trrh248
\pard\plain\intbl\li220\fi-220\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 13,275,086\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 5,262,690\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx6149\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6332\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7558\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8298\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9516\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9612\trrh248\row}}}\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\ql 9. Commitments and Contingencies\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi440\cf1\f51\fs20\b\ql Manufacturing Agreements\plain\cf1\f51\fs20\ql \u8212?The Company is party to manufacturing agreements with vendors to manufacture\plain\cf1\f51\fs20\ql TRX518 and DKN-01, its lead product candidates, for use in clinical trials. As of March\~31, 2019, the Company did not have\plain\cf1\f51\fs20\ql any noncancelable commitments under these agreements.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi440\cf1\f51\fs20\b\ql License and Service Agreement\plain\cf1\f51\fs20\ql \u8212?On January\~3, 2011, the Company entered into a license agreement with Eli Lilly\plain\cf1\f51\fs20\ql and Company (\u8220?Lilly\u8221?) to grant a license to the Company for certain intellectual property rights relating to\plain\cf1\f51\fs20\ql pharmaceutically active compounds that may be useful in the treatment of bone healing, cancer and, potentially, other medical\plain\cf1\f51\fs20\ql conditions. The Company previously issued 9,000,000 shares of Series\~A Stock to Lilly in consideration for the grant of the\plain\cf1\f51\fs20\ql license. As defined in the license agreement, the Company would be required to pay royalties to Lilly based upon a percentage in\plain\cf1\f51\fs20\ql the low single digits of net sales of developed products, if and when achieved. However, there can be no assurance that clinical\plain\cf1\f51\fs20\ql or commercialization success of developed products will occur, and no royalties have been paid or accrued through March\~31,\plain\cf1\f51\fs20\ql 2019.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi616\cf1\f51\fs20\b\ql License Agreement\plain\cf1\f51\fs20\ql \u8212?On May\~28, 2015, the Company entered into a license agreement with Lonza Sales AG\plain\cf1\f51\fs20\ql (\u8220?Lonza\u8221?), pursuant to which Lonza granted the Company a world-wide, non-exclusive license for certain\plain\cf1\f51\fs20\ql intellectual property relating to a gene expression system for manufacturing DKN-01. As defined in the license agreement, the\plain\cf1\f51\fs20\ql Company would be required to pay royalties to Lonza based on a percentage in the low single digits of net sales of DKN-01, if\plain\cf1\f51\fs20\ql and when achieved. However, there can be no assurance that clinical or commercialization success will occur, and no royalties\plain\cf1\f51\fs20\ql have been paid or accrued through March\~31, 2019.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi616\cf1\f51\fs20\b\ql Legal Proceedings\plain\cf1\f51\fs20\ql \u8212?At each reporting date, the Company evaluates whether or not a potential loss amount or a\plain\cf1\f51\fs20\ql potential range of loss is probable and reasonably estimable under the provisions of the authoritative guidance that addresses\plain\cf1\f51\fs20\ql accounting for contingencies. The Company expenses as incurred the costs related to its legal proceedings.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi440\cf1\f51\fs20\ql A patent covering the TRX518 antibody and its uses in methods of inducing or enhancing an immune response in a subject\plain\cf1\f51\fs20\ql was granted in 2013 to the Company by the European Patent Office (EPO). Three notices of opposition to this patent were filed:\plain\cf1\f51\fs20\ql two by major pharmaceutical companies and a third by an individual, possibly on behalf of a major pharmaceutical company. At\plain\cf1\f51\fs20\ql the conclusion of the opposition proceedings before the Opposition Division of the EPO, the Opposition Division issued a\plain\cf1\f51\fs20\ql decision indicating that the Company\u8217?s patent was maintained with modified claims that differ from the claims as\plain\cf1\f51\fs20\ql originally granted. These narrowed claims cover the TRX518 antibody and uses of the TRX518 antibody in methods of inducing\plain\cf1\f51\fs20\ql or enhancing an immune response in a subject. The Company has filed an appeal of the decision of the Opposition Division\plain\cf1\f51\fs20\ql seeking to obtain broader claims that more closely reflect the claims as granted in the patent. The EPO Board of Appeal has not\plain\cf1\f51\fs20\ql yet scheduled a date for the appeal hearing.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\qc 22{\*\bkmkstart pb_22_020413_1789_12906402}{\*\bkmkend pb_22_020413_1789_12906402}\par\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par
\page\pard\plain\ul{\field{\*\fldinst HYPERLINK \\l "tableofcontents_12906402" }{\*\fldrslt\cf3\f51\fs20\ql Table of Contents}}\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi440\cf1\f51\fs20\ql In 2016, a patent covering the use of the TRX518 antibody in combination with a chemotherapeutic agent for treating cancer\plain\cf1\f51\fs20\ql was granted to the Company by the EPO. In March\~2017, notices of opposition to this patent were filed at the EPO by ten\plain\cf1\f51\fs20\ql different entities, including several major pharmaceutical companies. Oral proceedings at the EPO took place on December\~4 and\plain\cf1\f51\fs20\ql 5, 2018. At the conclusion of the oral proceedings, the Opposition Division decided that the patent should be revoked in its\plain\cf1\f51\fs20\ql entirety on the ground that the claims as granted contained added matter. Subsequently, the Opposition Division issued an\plain\cf1\f51\fs20\ql interlocutory decision restating its conclusion that the claims as granted contained added matter and revoking the patent. The\plain\cf1\f51\fs20\ql Company has filed an appeal of the decision of the Opposition Division seeking to obtain a reversal of the Opposition\plain\cf1\f51\fs20\ql Division\u8217?s decision on added matter. A statement of our grounds of appeal is due on May\~23, 2019. The EPO Board of\plain\cf1\f51\fs20\ql Appeal has not yet scheduled a date for the appeal hearing.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi616\cf1\f51\fs20\b\ql Indemnification Agreements\plain\cf1\f51\fs20\ql \u8212?In the ordinary course of business, the Company may provide indemnification of\plain\cf1\f51\fs20\ql varying scope and terms to vendors, lessors, business partners and other parties with respect to certain matters including, but not\plain\cf1\f51\fs20\ql limited to, losses arising out of breach of such agreements or from intellectual property infringement claims made by third\plain\cf1\f51\fs20\ql parties. In addition, the Company has entered into indemnification agreements with members of its board of directors that will\plain\cf1\f51\fs20\ql require the Company, among other things, to indemnify them against certain liabilities that may arise by reason of their status or\plain\cf1\f51\fs20\ql service as directors or officers. The maximum potential amount of future payments the Company could be required to make\plain\cf1\f51\fs20\ql under these indemnification agreements is, in many cases, unlimited. To date, the Company has not incurred any material costs as\plain\cf1\f51\fs20\ql a result of such indemnifications. The Company is not aware of any claims under indemnification arrangements, and it has not\plain\cf1\f51\fs20\ql accrued any liabilities related to such obligations in its condensed consolidated financial statements as of March\~31, 2019 or\plain\cf1\f51\fs20\ql December\~31, 2018.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\qc 23{\*\bkmkstart pb_23_020541_7056_12906402}{\*\bkmkend pb_23_020541_7056_12906402}\par\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par
\page\pard\plain\ul{\field{\*\fldinst HYPERLINK \\l "tableofcontents_12906402" }{\*\fldrslt\cf3\f51\fs20\ql Table of Contents}}\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\ql 10. Related Party Transactions\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi616\cf1\f51\fs20\ql The Company has a license agreement with a stockholder (See Note\~9).\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi616\cf1\f51\fs20\ql On February\~5, 2019, the Company completed the 2019 Public Offering pursuant to which the Company issued 7,557,142\plain\cf1\f51\fs20\ql shares of its common stock at a price of $1.75 per share, which included 985,714 shares issued pursuant to the\plain\cf1\f51\fs20\ql underwriters\u8217? exercise of their option to purchase additional shares of common stock, each share issued with a warrant to\plain\cf1\f51\fs20\ql purchase one share of common stock. Each warrant has an exercise price of $1.95 per share with an exercise period expiring\plain\cf1\f51\fs20\ql seven years from the date of issuance. The aggregate net proceeds received by the Company from the offering were\plain\cf1\f51\fs20\ql approximately $12,122, net of underwriting discounts and commissions and estimated offering expenses payable by the\plain\cf1\f51\fs20\ql Company.\~ HealthCare Ventures IX,\~L.P. purchased common stock and warrants in the 2019 Public Offering on the same terms\plain\cf1\f51\fs20\ql and conditions as the other Purchasers. Three of the Company\u8217?s directors and executive officers are affiliated with\plain\cf1\f51\fs20\ql HealthCare Ventures IX,\~L.P. and its affiliates.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\qc 24{\*\bkmkstart pb_24_020554_5335_12906402}{\*\bkmkend pb_24_020554_5335_12906402}\par\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par
\page\pard\plain\ul{\field{\*\fldinst HYPERLINK \\l "tableofcontents_12906402" }{\*\fldrslt\cf3\f51\fs20\ql Table of Contents}}\par\pard\plain\cf1\f51\fs20\ql \~{\*\bkmkstart item_1_3_2}{\*\bkmkend item_1_3_2}\par\pard\plain\cf1\f51\fs20\b\ql Item 2. Management\u8217?s Discussion and Analysis of Financial Condition and Results of Operations{\*\bkmkstart item2_managementsdiscussionandan}{\*\bkmkend item2_managementsdiscussionandan}\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi748\cf1\f51\fs20\i\ql The following Management\u8217?s Discussion and Analysis of Financial Condition and Results of Operations\plain\cf1\f51\fs20\i\ql (\u8220?MD&A\u8221?) is intended to help the reader understand our results of operations and financial condition. This MD&A\plain\cf1\f51\fs20\i\ql is provided as a supplement to, and should be read in conjunction with, our condensed consolidated financial statements and the\plain\cf1\f51\fs20\i\ql accompanying notes thereto and other disclosures included in this Quarterly Report on Form\~10-Q, including the disclosures\plain\cf1\f51\fs20\i\ql under Part\~II,\~Item IA \u8220?Risk Factors\u8221?, and our audited condensed consolidated financial statements and the\plain\cf1\f51\fs20\i\ql accompanying notes thereto included in our Annual Report on Form\~10-K for the year ended December\~31, 2018, which was\plain\cf1\f51\fs20\i\ql filed with the Securities and Exchange Commission, or the SEC, on April\~1, 2019. Our condensed consolidated financial\plain\cf1\f51\fs20\i\ql statements have been prepared in accordance with U.S. GAAP and, unless otherwise indicated, amounts are presented in U.S.\plain\cf1\f51\fs20\i\ql dollars.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\ql Company Overview\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi748\cf1\f51\fs20\ql We are a biopharmaceutical company developing novel therapies designed to treat patients with cancer by inhibiting\plain\cf1\f51\fs20\ql fundamental tumor-promoting pathways and by harnessing the immune system to attack cancer cells. Our strategy is to identify,\plain\cf1\f51\fs20\ql acquire, and develop molecules that will rapidly translate into high impact therapeutics that generate durable clinical benefit and\plain\cf1\f51\fs20\ql enhanced patient outcomes.\~ Our two clinical stage programs are:\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\li836\fi-352\cf1\f53\fs20\ql ·\plain\li836\cf1\f51\fs20\ql \~\~\~\~\~\~\~\~\~\plain\li836\cf1\f51\fs20\i\ql DKN-01:\~\plain\li836\cf1\f51\fs20\ql A monoclonal antibody that inhibits Dickkopf-related protein 1, or DKK1. DKK1 is a protein that\plain\li836\cf1\f51\fs20\ql regulates the Wnt signaling pathways and enables tumor cells to profilerate and spread, as well as suppresses the\plain\li836\cf1\f51\fs20\ql immune system from attacking the tumor. When DKN-01 binds to DKK1, an anti-tumor effect can be generated.\plain\li836\cf1\f51\fs20\ql DKN-01-based therapies have generated responses and clinical benefit in several patient populations. We are currently\plain\li836\cf1\f51\fs20\ql studying DKN-01 in multiple ongoing clinical trials in patients with esophagogastric cancer, hepatobiliary cancer,\plain\li836\cf1\f51\fs20\ql gynecologic cancers, or prostate cancer.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\li836\fi-352\cf1\f53\fs20\ql ·\plain\li836\cf1\f51\fs20\ql \~\~\~\~\~\~\~\~\~\plain\li836\cf1\f51\fs20\i\ql TRX518:\~\plain\li836\cf1\f51\fs20\ql A monoclonal antibody targeting the glucocorticoid-induced tumor necrosis factor-related receptor, or\plain\li836\cf1\f51\fs20\ql GITR. GITR is a receptor found on the surface of a wide range of immune cells. GITR stimulation activates tumor\plain\li836\cf1\f51\fs20\ql fighting white blood cells and decrease the activity of potentially tumor-protective immunosuppressive cells. TRX518\plain\li836\cf1\f51\fs20\ql has been specifically engineered to enhance the immune system\u8217?s anti-tumor response by activating GITR\plain\li836\cf1\f51\fs20\ql signaling without causing the immune cells to be destroyed. We are conducting clinical trials of TRX518 in patients\plain\li836\cf1\f51\fs20\ql with advanced solid tumors in combination with gemcitabine chemotherapy or with cancer immunotherapies known as\plain\li836\cf1\f51\fs20\ql PD-1 antagonists.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi638\cf1\f51\fs20\ql We intend to apply our extensive experience identifying and developing transformational products to aggressively develop\plain\cf1\f51\fs20\ql these antibodies and build a pipeline of programs that has the potential to change the practice of cancer medicine.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\ql Recent Developments\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi748\cf1\f51\fs20\ql Since the year ended December\~31, 2018, we have continued to make strong progress with the development of our\plain\cf1\f51\fs20\ql product candidates:\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\li1122\fi-264\cf1\f53\fs20\ql ·\plain\li1122\cf1\f51\fs6\ql \~\~\~\~\~\~\~\~\~\~\~\~\~\~\~\~\~\plain\li1122\cf1\f51\fs20\b\i\ql DKN-01 in ESOPHAGOGASTRIC CANCER\plain\li1122\cf1\f51\fs20\ql :\~ We presented clinical data from our study evaluating DKN-01 in\plain\li1122\cf1\f51\fs20\ql combination with KEYTRUDA\u174? (pembrolizumab) in patients with advanced esophagogastric cancer. The\plain\li1122\cf1\f51\fs20\ql overall response rate and disease control rate has been higher in patients with higher DKK1 expression as measured\plain\li1122\cf1\f51\fs20\ql by in situ hybridization RNAscope. Enrollment in this study is complete.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\li1122\fi-264\cf1\f53\fs20\ql ·\plain\li1122\cf1\f51\fs6\ql \~\~\~\~\~\~\~\~\~\~\~\~\~\~\~\~\~\plain\li1122\cf1\f51\fs20\b\i\ql DKN-01 in GYNECOLOGICAL CANCERS\plain\li1122\cf1\f51\fs20\ql :\~ At the Society for Gynecologic Oncology 50th Annual Meeting on\plain\li1122\cf1\f51\fs20\ql Women\u8217?s Cancer, we presented an update on our clinical study evaluating DKN-01 as a monotherapy and in\plain\li1122\cf1\f51\fs20\ql combination with paclitaxel in patients with advanced gynecological cancers.\~DKN-01 monotherapy has generated\plain\li1122\cf1\f51\fs20\ql two partial responses in patients with endometrial cancer, and DKN-01 plus paclitaxel has generated a partial\plain\li1122\cf1\f51\fs20\ql response in a patient with carcinosarcoma. An additional DKN-01 monotherapy patient was initially reported by the\plain\li1122\cf1\f51\fs20\ql treating investigator to have experienced a partial response; however, further follow-up identified that the patient has\plain\li1122\cf1\f51\fs20\ql a tumor reduction that does not meet the threshold for a partial response and remains on treatment with ongoing\plain\li1122\cf1\f51\fs20\ql clinical benefit. Eighty-seven patients have been enrolled in the study, and enrollment is ongoing.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\li1122\fi-264\cf1\f53\fs20\ql ·\plain\li1122\cf1\f51\fs6\ql \~\~\~\~\~\~\~\~\~\~\~\~\~\~\~\~\~\plain\li1122\cf1\f51\fs20\b\i\ql DKN-01 in PROSTATE CANCER\plain\li1122\cf1\f51\fs20\ql :\~ The first patient has been enrolled in our investigator-initiated study of\plain\li1122\cf1\f51\fs20\ql DKN-01 as a monotherapy and in combination with docetaxel in DKK1-positive metastatic prostate cancer patients.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\li1122\fi-264\cf1\f53\fs20\ql ·\plain\li1122\cf1\f51\fs6\ql \~\~\~\~\~\~\~\~\~\~\~\~\~\~\~\~\~\plain\li1122\cf1\f51\fs20\b\i\ql TRX518 MONOTHERAPY\plain\li1122\cf1\f51\fs20\ql :\~ A non-virally mediated hepatocellular cancer patient, who has been treated with\plain\li1122\cf1\f51\fs20\ql single agent TRX518 for two years, achieved a best response of partial response. With recent disease progression,\plain\li1122\cf1\f51\fs20\ql this patient now continues on treatment for clinical benefit.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\qc 25{\*\bkmkstart pb_25_021426_7569_12906402}{\*\bkmkend pb_25_021426_7569_12906402}\par\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par
\page\pard\plain\ul{\field{\*\fldinst HYPERLINK \\l "tableofcontents_12906402" }{\*\fldrslt\cf3\f51\fs20\ql Table of Contents}}\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\li1122\fi-264\cf1\f53\fs20\ql ·\plain\li1122\cf1\f51\fs6\ql \~\~\~\~\~\~\~\~\~\~\~\~\~\~\~\~\~\plain\li1122\cf1\f51\fs20\b\i\ql TRX518 COMBINATION THERAPY\plain\li1122\cf1\f51\fs20\ql :\~ We presented data from our clinical trial evaluating TRX518 in\plain\li1122\cf1\f51\fs20\ql combination with gemcitabine chemotherapy or in combination with KEYTRUDA or OPDIVO\u174? (nivolumab),\plain\li1122\cf1\f51\fs20\ql with patients from each combination arm experiencing responses and durable stable disease.\~ Eighteen patients have\plain\li1122\cf1\f51\fs20\ql been enrolled in the TRX518/KEYTRUDA expansion cohort, and enrollment is ongoing.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\ql Financial Overview\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\li1452\fi-616\cf1\f51\fs20\b\i\ql Research and Development Expenses\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi352\cf1\f51\fs20\ql Our research and development activities have included conducting nonclinical studies and clinical trials, manufacturing\plain\cf1\f51\fs20\ql development efforts and activities related to regulatory filings for DKN-01 and TRX518. We recognize research and\plain\cf1\f51\fs20\ql development expenses as they are incurred. Our research and development expenses consist primarily of:\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\li1166\fi-352\cf1\f53\fs20\ql ·\plain\li1166\cf1\f51\fs6\ql \~\~\~\~\~\~\~\~\~\~\~\~\~\~\~\plain\li1166\cf1\f51\fs20\ql salaries and related overhead expenses for personnel in research and development functions, including costs related\plain\li1166\cf1\f51\fs20\ql to stock-based compensation;\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\li1166\fi-352\cf1\f53\fs20\ql ·\plain\li1166\cf1\f51\fs6\ql \~\~\~\~\~\~\~\~\~\~\~\~\~\~\~\plain\li1166\cf1\f51\fs20\ql fees paid to consultants and CROs for our nonclinical and clinical trials, and other related clinical trial fees,\plain\li1166\cf1\f51\fs20\ql including but not limited to laboratory work, clinical trial database management, clinical trial material management\plain\li1166\cf1\f51\fs20\ql and statistical compilation and analysis;\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\li1166\fi-352\cf1\f53\fs20\ql ·\plain\li1166\cf1\f51\fs6\ql \~\~\~\~\~\~\~\~\~\~\~\~\~\~\~\plain\li1166\cf1\f51\fs20\ql costs related to acquiring and manufacturing clinical trial material; and\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\li1166\fi-352\cf1\f53\fs20\ql ·\plain\li1166\cf1\f51\fs6\ql \~\~\~\~\~\~\~\~\~\~\~\~\~\~\~\plain\li1166\cf1\f51\fs20\ql costs related to compliance with regulatory requirements.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi616\cf1\f51\fs20\ql We plan to increase our research and development expenses for the foreseeable future as we continue the development of\plain\cf1\f51\fs20\ql DKN-01, TRX518 and any other product candidates, subject to the availability of additional funding.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi616\cf1\f51\fs20\ql Our direct research and development expenses are tracked on a program-by-program basis and consist primarily of\plain\cf1\f51\fs20\ql internal and external costs, such as employee costs, including salaries and stock-based compensation, other internal costs, fees\plain\cf1\f51\fs20\ql paid to consultants, central laboratories, contractors and CROs in connection with our clinical and preclinical trial development\plain\cf1\f51\fs20\ql activities. We use internal resources to manage our clinical and preclinical trial development activities and perform data analysis\plain\cf1\f51\fs20\ql for such activities.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi616\cf1\f51\fs20\ql We participate, through our subsidiary in Australia, in the Australian government\u8217?s research and development\plain\cf1\f51\fs20\ql (\u8220?R&D\u8221?) Incentive program, such that a percentage of our eligible research and development expenses are\plain\cf1\f51\fs20\ql reimbursed by the Australian government as a refundable tax offset and such incentives are reflected as other income.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi616\cf1\f51\fs20\ql The table below summarizes our research and development expenses incurred by development program and the R&D\plain\cf1\f51\fs20\ql Incentive income for the three months ended March\~31, 2019 and 2018:\par\pard\plain\cf1\f51\fs20\ql \~
\par\pard\plain
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\pard\plain\intbl\cf1\f51\fs2\b\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs16\b\qc Three\~Months\~Ended\~March\~31,\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell{
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\pard\plain\intbl\cf1\f51\fs2\b\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs16\b\qc 2019\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs16\b\qc 2018\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell{
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\pard\plain\intbl\cf1\f51\fs2\b\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs16\b\qc (in\~thousands)\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell{
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\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\ql Direct research and development by program:\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\qr \~\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\qr \~\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
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\pard\plain\intbl\li440\fi-220\cf1\f51\fs20\ql DKN-01 program\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr 5,375\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr 3,193\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
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\pard\plain\intbl\li440\fi-220\cf1\f51\fs20\ql TRX518 program\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 1,415\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 1,038\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
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\pard\plain\intbl\li660\fi-220\cf1\f51\fs20\ql Total research and development expenses\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr 6,790\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr 4,231\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
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\pard\plain\intbl\li660\fi-220\cf1\f51\fs20\ql Australian research and development incentives\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr 75\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr 646\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx5224\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5438\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5882\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6887\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7331\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7775\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8780\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8856\trrh248\row}}}\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi440\cf1\f51\fs20\ql The successful development of our clinical product candidates is highly uncertain. At this time, we cannot reasonably\plain\cf1\f51\fs20\ql estimate the nature, timing or costs of the efforts that will be necessary to complete the remainder of the development of any of\plain\cf1\f51\fs20\ql our product candidates or the period, if any, in which material net cash inflows from these product candidates may commence.\plain\cf1\f51\fs20\ql This is due to the numerous risks and uncertainties associated with developing drugs, including the uncertainty of:\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\li1166\fi-352\cf1\f53\fs20\ql ·\plain\li1166\cf1\f51\fs6\ql \~\~\~\~\~\~\~\~\~\~\~\~\~\~\~\plain\li1166\cf1\f51\fs20\ql the scope, rate of progress and expense of our ongoing, as well as any additional, clinical trials and other research\plain\li1166\cf1\f51\fs20\ql and development activities;\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\li1166\fi-352\cf1\f53\fs20\ql ·\plain\li1166\cf1\f51\fs6\ql \~\~\~\~\~\~\~\~\~\~\~\~\~\~\~\plain\li1166\cf1\f51\fs20\ql future clinical trial results; and\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\qc 26{\*\bkmkstart pb_26_022140_7056_12906402}{\*\bkmkend pb_26_022140_7056_12906402}\par\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par
\page\pard\plain\ul{\field{\*\fldinst HYPERLINK \\l "tableofcontents_12906402" }{\*\fldrslt\cf3\f51\fs20\ql Table of Contents}}\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\li1166\fi-352\cf1\f53\fs20\ql ·\plain\li1166\cf1\f51\fs6\ql \~\~\~\~\~\~\~\~\~\~\~\~\~\~\~\plain\li1166\cf1\f51\fs20\ql the timing and receipt of any regulatory approvals.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi616\cf1\f51\fs20\ql A change in the outcome of any of these variables with respect to the development of a product candidate could result in\plain\cf1\f51\fs20\ql a significant change in the costs and timing associated with the development of that product candidate. For example, if the FDA\plain\cf1\f51\fs20\ql or another regulatory authority were to require us to conduct clinical trials beyond those that we currently anticipate will be\plain\cf1\f51\fs20\ql required for the completion of clinical development of a product candidate, or if we experience significant delays in enrollment in\plain\cf1\f51\fs20\ql any of our clinical trials, we could be required to expend significant additional financial resources and time on the completion of\plain\cf1\f51\fs20\ql clinical development.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\li1452\fi-308\cf1\f51\fs20\b\i\ql General and Administrative Expenses\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi616\cf1\f51\fs20\ql General and administrative expenses consist primarily of salaries and related costs, including stock-based compensation,\plain\cf1\f51\fs20\ql for personnel in executive, finance and administrative functions. General and administrative expenses also include direct and\plain\cf1\f51\fs20\ql allocated facility-related costs as well as professional fees for legal, patent, consulting, accounting and audit services.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi616\cf1\f51\fs20\ql We anticipate that our general and administrative expenses will increase in the future as we increase our headcount to\plain\cf1\f51\fs20\ql support our continued research activities and development of our product candidates. We also anticipate that we will incur\plain\cf1\f51\fs20\ql increased accounting, audit, legal, regulatory, compliance, director and officer insurance costs as well as investor and public\plain\cf1\f51\fs20\ql relations expenses associated with being a public company.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\li1452\fi-308\cf1\f51\fs20\b\i\ql Interest income\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi616\cf1\f51\fs20\ql Interest income consists primarily of interest income earned on cash and cash equivalents.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\li1452\fi-308\cf1\f51\fs20\b\i\ql Research and development incentive income\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi616\cf1\f51\fs20\ql Research and development incentive income includes payments under the R&D Incentive program from the government of\plain\cf1\f51\fs20\ql Australia. The R&D Incentive is one of the key elements of the Australian Government\u8217?s support for Australia\u8217?s\plain\cf1\f51\fs20\ql innovation system. It was developed to assist businesses to recover some of the costs of undertaking research and development.\plain\cf1\f51\fs20\ql The research and development tax incentive provides a tax offset to eligible companies that engage in research and development\plain\cf1\f51\fs20\ql activities.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi616\cf1\f51\fs20\ql Companies engaged in research and development may be eligible for either:\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\li1166\fi-352\cf1\f53\fs20\ql ·\plain\li1166\cf1\f51\fs6\ql \~\~\~\~\~\~\~\~\~\~\~\~\~\~\~\plain\li1166\cf1\f51\fs20\ql a 43.5% refundable tax offset for entities with an aggregated turnover of less than A$20\~million per annum, or\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\li1166\fi-352\cf1\f53\fs20\ql ·\plain\li1166\cf1\f51\fs6\ql \~\~\~\~\~\~\~\~\~\~\~\~\~\~\~\plain\li1166\cf1\f51\fs20\ql a 38.5% non-refundable tax offset for all other entities.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi616\cf1\f51\fs20\ql We recognize as income the amount we expect to be reimbursed for qualified expenses.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\li1452\fi-308\cf1\f51\fs20\b\i\ql Foreign currency translation adjustment\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi616\cf1\f51\fs20\ql Foreign currency translation adjustment consists of gains (losses) due to the revaluation of foreign currency transactions\plain\cf1\f51\fs20\ql attributable to changes in foreign currency exchange rates associated with our Australian subsidiary.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\qc 27{\*\bkmkstart pb_27_022218_5335_12906402}{\*\bkmkend pb_27_022218_5335_12906402}\par\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par
\page\pard\plain\ul{\field{\*\fldinst HYPERLINK \\l "tableofcontents_12906402" }{\*\fldrslt\cf3\f51\fs20\ql Table of Contents}}\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\ql Critical Accounting Policies and Estimates\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi726\cf1\f51\fs20\ql Our condensed consolidated financial statements are prepared in accordance with generally accepted accounting principles\plain\cf1\f51\fs20\ql in the United States, or GAAP. The preparation of our financial statements and related disclosures requires us to make estimates\plain\cf1\f51\fs20\ql and judgments that affect the reported amounts of assets, liabilities, revenue, costs and expenses, and the disclosure of contingent\plain\cf1\f51\fs20\ql assets and liabilities in our financial statements. We base our estimates on historical experience, known trends and events and\plain\cf1\f51\fs20\ql various other factors that we believe are reasonable under the circumstances, the results of which form the basis for making\plain\cf1\f51\fs20\ql judgments about the carrying values of assets and liabilities that are not readily apparent from other sources. We evaluate our\plain\cf1\f51\fs20\ql estimates and assumptions on an ongoing basis. Our actual results may differ from these estimates under different assumptions or\plain\cf1\f51\fs20\ql conditions.\par\pard\plain\fi726\cf1\f51\fs20\ql \~\par\pard\plain\fi726\cf1\f51\fs20\ql On January\~1, 2019, we adopted ASU No.\~2017-11,\plain\cf1\f51\fs20\i\ql Earnings Per Share (Topic 260), Distinguishing Liabilities from\plain\cf1\f51\fs20\i\ql Equity (Topic 480), and Derivatives and Hedging (Topic 815)\plain\cf1\f51\fs20\ql (\u8220?ASU 2017-11\u8221?), which changes the classification\plain\cf1\f51\fs20\ql analysis of certain equity-linked financial instruments (or embedded features) with down round features, and Topic 842, Leases,\plain\cf1\f51\fs20\ql (\u8220?ASU 2016-02), which requires lessees to recognize leases on the balance sheet and disclose key information about\plain\cf1\f51\fs20\ql leasing arrangements.\par\pard\plain\fi726\cf1\f51\fs20\ql \~\par\pard\plain\fi726\cf1\f51\fs20\ql Our critical accounting policies are described under the heading \u8220?Management\u8217?s Discussion and Analysis of\plain\cf1\f51\fs20\ql Financial Condition and Results of Operations\u8212? Critical Accounting Policies and Significant Judgments and\plain\cf1\f51\fs20\ql Estimates\u8221? in our Annual Report on Form\~10-K filed with the Securities and Exchange Commission, or SEC, on April\~1,\plain\cf1\f51\fs20\ql 2019 and the notes to the condensed consolidated financial statements appearing elsewhere in this Quarterly Report\plain\cf1\f51\fs20\ql on\~Form\~10-Q.\~We believe that of our critical accounting policies, the following accounting policies involve the most judgment\plain\cf1\f51\fs20\ql and complexity:\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\li1166\fi-352\cf1\f53\fs20\ql ·\plain\li1166\cf1\f51\fs6\ql \~\~\~\~\~\~\~\~\~\~\~\~\~\~\~\plain\li1166\cf1\f51\fs20\ql accrued research and development expenses;\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\li1166\fi-352\cf1\f53\fs20\ql ·\plain\li1166\cf1\f51\fs6\ql \~\~\~\~\~\~\~\~\~\~\~\~\~\~\~\plain\li1166\cf1\f51\fs20\ql research and development incentive receivable; and\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\li1166\fi-352\cf1\f53\fs20\ql ·\plain\li1166\cf1\f51\fs6\ql \~\~\~\~\~\~\~\~\~\~\~\~\~\~\~\plain\li1166\cf1\f51\fs20\ql stock-based compensation.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\ql Results of Operations\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\i\ql Comparison of the Three Months Ended March\~31, 2019 and 2018\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi616\cf1\f51\fs20\ql The following table summarizes our results of operations for the three months ended March\~31, 2019 and 2018:\par\pard\plain\cf1\f51\fs20\ql \~
\par\pard\plain
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\pard\plain\intbl\cf1\f51\fs2\b\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs16\b\qc Three\~Months\~Ended\~March\~31,\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell{
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{\trowd\clvertalb\cellx4307\clvertalb\cellx4457\clbrdrb\brdrs\brdrcf1\clvertalb\cellx5888\clvertalb\cellx6332\clbrdrb\brdrs\brdrcf1\clvertalb\cellx7785\clvertalb\cellx7949\clbrdrb\brdrs\brdrcf1\clvertalb\cellx9194\clvertalb\cellx9288\trrh198
\pard\plain\intbl\cf1\f51\fs2\b\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs16\b\qc 2019\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs16\b\qc 2018\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs16\b\qc Change\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell{
{\trowd\clvertalb\cellx4307\clvertalb\cellx4457\clbrdrb\brdrs\brdrcf1\clvertalb\cellx5888\clvertalb\cellx6332\clbrdrb\brdrs\brdrcf1\clvertalb\cellx7785\clvertalb\cellx7949\clbrdrb\brdrs\brdrcf1\clvertalb\cellx9194\clvertalb\cellx9288\trrh198\row}}}
{\trowd\clvertalb\cellx4307\clvertalb\cellx4457\clvertalb\cellx7786\clvertalb\cellx7950\clvertalb\cellx9195\clvertalb\cellx9288\trrh198
\pard\plain\intbl\cf1\f51\fs2\b\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs16\b\qc (in\~thousands)\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell{
{\trowd\clvertalb\cellx4307\clvertalb\cellx4457\clvertalb\cellx7786\clvertalb\cellx7950\clvertalb\cellx9195\clvertalb\cellx9288\trrh198\row}}}
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx4307\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4457\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5888\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6332\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7785\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7949\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9194\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9288\trrh248
\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\ql Operating expenses:\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\qr \~\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\qr \~\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\qr \~\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx4307\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4457\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5888\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6332\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7785\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7949\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9194\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9288\trrh248\row}}}
{\trowd\cellx4307\clvertalb\cellx4457\clvertalb\cellx4900\clvertalb\cellx5887\clvertalb\cellx6331\clvertalb\cellx6775\clvertalb\cellx7784\clvertalb\cellx7948\clvertalb\cellx8220\clvertalb\cellx9193\clvertalb\cellx9288\trrh248
\pard\plain\intbl\li440\fi-220\cf1\f51\fs20\ql Research and development\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr 6,790\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr 4,231\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr 2,559\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
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{\trowd\clshdng100\clcfpat11\clcbpat11\cellx4307\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4457\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5888\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6332\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7785\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7949\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9194\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9288\trrh248
\pard\plain\intbl\li440\fi-220\cf1\f51\fs20\ql General and administrative\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 2,005\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 2,113\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr (108\cell\pard\plain\intbl\cf1\f51\fs20\ql )\cell{
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx4307\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4457\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5888\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6332\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7785\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7949\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9194\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9288\trrh248\row}}}
{\trowd\cellx4307\clvertalb\cellx4457\clbrdrb\brdrs\brdrcf1\clvertalb\cellx5888\clvertalb\cellx6332\clbrdrb\brdrs\brdrcf1\clvertalb\cellx7785\clvertalb\cellx7949\clbrdrb\brdrs\brdrcf1\clvertalb\cellx9194\clvertalb\cellx9288\trrh248
\pard\plain\intbl\li660\fi-220\cf1\f51\fs20\ql Total operating expenses\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 8,795\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 6,344\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 2,451\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\cellx4307\clvertalb\cellx4457\clbrdrb\brdrs\brdrcf1\clvertalb\cellx5888\clvertalb\cellx6332\clbrdrb\brdrs\brdrcf1\clvertalb\cellx7785\clvertalb\cellx7949\clbrdrb\brdrs\brdrcf1\clvertalb\cellx9194\clvertalb\cellx9288\trrh248\row}}}
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx4307\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4457\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5888\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6332\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7785\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7949\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9194\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9288\trrh248
\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\ql Loss from operations\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr (8,795\cell\pard\plain\intbl\cf1\f51\fs20\ql )\cell\pard\plain\intbl\cf1\f51\fs20\qr (6,344\cell\pard\plain\intbl\cf1\f51\fs20\ql )\cell\pard\plain\intbl\cf1\f51\fs20\qr (2,451\cell\pard\plain\intbl\cf1\f51\fs20\ql )\cell{
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{\trowd\cellx4307\clvertalb\cellx4457\clvertalb\cellx5888\clvertalb\cellx6332\clvertalb\cellx7785\clvertalb\cellx7949\clvertalb\cellx9194\clvertalb\cellx9288\trrh248
\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\ql Interest income\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 82\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 77\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 5\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\cellx4307\clvertalb\cellx4457\clvertalb\cellx5888\clvertalb\cellx6332\clvertalb\cellx7785\clvertalb\cellx7949\clvertalb\cellx9194\clvertalb\cellx9288\trrh248\row}}}
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx4307\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4457\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5888\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6332\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7785\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7949\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9194\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9288\trrh248
\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\ql Interest expense\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr (7\cell\pard\plain\intbl\cf1\f51\fs20\ql )\cell\pard\plain\intbl\cf1\f51\fs20\qr (6\cell\pard\plain\intbl\cf1\f51\fs20\ql )\cell\pard\plain\intbl\cf1\f51\fs20\qr (1\cell\pard\plain\intbl\cf1\f51\fs20\ql )\cell{
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx4307\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4457\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5888\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6332\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7785\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7949\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9194\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9288\trrh248\row}}}
{\trowd\cellx4307\clvertalb\cellx4457\clvertalb\cellx5888\clvertalb\cellx6332\clvertalb\cellx7785\clvertalb\cellx7949\clvertalb\cellx9194\clvertalb\cellx9288\trrh248
\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\ql Australian research and development incentives\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 75\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 646\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr (571\cell\pard\plain\intbl\cf1\f51\fs20\ql )\cell{
{\trowd\cellx4307\clvertalb\cellx4457\clvertalb\cellx5888\clvertalb\cellx6332\clvertalb\cellx7785\clvertalb\cellx7949\clvertalb\cellx9194\clvertalb\cellx9288\trrh248\row}}}
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx4307\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4457\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5888\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6332\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7785\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7949\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9194\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9288\trrh248
\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\ql Foreign currency gains\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 42\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr (144\cell\pard\plain\intbl\cf1\f51\fs20\ql )\cell\pard\plain\intbl\cf1\f51\fs20\qr 186\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx4307\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4457\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5888\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6332\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7785\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7949\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9194\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9288\trrh248\row}}}
{\trowd\cellx4307\clvertalb\cellx4457\clbrdrb\brdrs\brdrcf1\clvertalb\cellx5888\clvertalb\cellx6332\clbrdrb\brdrs\brdrcf1\clvertalb\cellx7785\clvertalb\cellx7949\clbrdrb\brdrs\brdrcf1\clvertalb\cellx9194\clvertalb\cellx9288\trrh248
\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\ql Loss on change in fair value of warrant liability\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr \u8212?\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr (4,851\cell\pard\plain\intbl\cf1\f51\fs20\ql )\cell\pard\plain\intbl\cf1\f51\fs20\qr 4,851\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\cellx4307\clvertalb\cellx4457\clbrdrb\brdrs\brdrcf1\clvertalb\cellx5888\clvertalb\cellx6332\clbrdrb\brdrs\brdrcf1\clvertalb\cellx7785\clvertalb\cellx7949\clbrdrb\brdrs\brdrcf1\clvertalb\cellx9194\clvertalb\cellx9288\trrh248\row}}}
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx4307\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4457\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4900\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5887\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6331\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6775\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7784\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7948\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8220\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9193\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9288\trrh248
\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\ql Net loss\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr (8,603\cell\pard\plain\intbl\cf1\f51\fs20\ql )\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr (10,622\cell\pard\plain\intbl\cf1\f51\fs20\ql )\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr 2,019\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx4307\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4457\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4900\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5887\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6331\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6775\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7784\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7948\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8220\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9193\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9288\trrh248\row}}}\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\qc 28{\*\bkmkstart pb_28_022939_5796_12906402}{\*\bkmkend pb_28_022939_5796_12906402}\par\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par
\page\pard\plain\ul{\field{\*\fldinst HYPERLINK \\l "tableofcontents_12906402" }{\*\fldrslt\cf3\f51\fs20\ql Table of Contents}}\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\li990\fi-154\cf1\f51\fs20\i\ql Research and Development Expenses\par\pard\plain\cf1\f51\fs20\ql \~
\par\pard\plain
{\trowd\clvertalb\cellx4303\clvertalb\cellx4452\clbrdrb\brdrs\brdrcf1\clvertalb\cellx7721\clvertalb\cellx7870\clvertalb\cellx9208\clvertalb\cellx9288\trrh198
\pard\plain\intbl\cf1\f51\fs2\b\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs16\b\qc Three\~Months\~Ended\~March\~31,\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs16\b\qc Increase\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell{
{\trowd\clvertalb\cellx4303\clvertalb\cellx4452\clbrdrb\brdrs\brdrcf1\clvertalb\cellx7721\clvertalb\cellx7870\clvertalb\cellx9208\clvertalb\cellx9288\trrh198\row}}}
{\trowd\clvertalb\cellx4303\clvertalb\cellx4452\clbrdrb\brdrs\brdrcf1\clvertalb\cellx5864\clvertalb\cellx6308\clbrdrb\brdrs\brdrcf1\clvertalb\cellx7720\clvertalb\cellx7869\clbrdrb\brdrs\brdrcf1\clvertalb\cellx9207\clvertalb\cellx9288\trrh198
\pard\plain\intbl\cf1\f51\fs2\b\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs16\b\qc 2019\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs16\b\qc 2018\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs16\b\qc (Decrease)\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell{
{\trowd\clvertalb\cellx4303\clvertalb\cellx4452\clbrdrb\brdrs\brdrcf1\clvertalb\cellx5864\clvertalb\cellx6308\clbrdrb\brdrs\brdrcf1\clvertalb\cellx7720\clvertalb\cellx7869\clbrdrb\brdrs\brdrcf1\clvertalb\cellx9207\clvertalb\cellx9288\trrh198\row}}}
{\trowd\clvertalb\cellx4303\clvertalb\cellx4452\clvertalb\cellx7721\clvertalb\cellx7870\clvertalb\cellx9208\clvertalb\cellx9288\trrh198
\pard\plain\intbl\cf1\f51\fs2\b\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs16\b\qc (in\~thousands)\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell{
{\trowd\clvertalb\cellx4303\clvertalb\cellx4452\clvertalb\cellx7721\clvertalb\cellx7870\clvertalb\cellx9208\clvertalb\cellx9288\trrh198\row}}}
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx4303\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4452\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5864\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6308\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7720\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7869\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9207\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9288\trrh248
\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\ql Direct research and development by program:\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\qr \~\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\qr \~\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\qr \~\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx4303\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4452\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5864\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6308\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7720\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7869\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9207\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9288\trrh248\row}}}
{\trowd\cellx4303\clvertalb\cellx4452\clvertalb\cellx4895\clvertalb\cellx5863\clvertalb\cellx6307\clvertalb\cellx6751\clvertalb\cellx7719\clvertalb\cellx7868\clvertalb\cellx8237\clvertalb\cellx9205\clvertalb\cellx9288\trrh248
\pard\plain\intbl\li440\fi-220\cf1\f51\fs20\ql DKN-01 program\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr 5,375\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr 3,193\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr 2,182\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\cellx4303\clvertalb\cellx4452\clvertalb\cellx4895\clvertalb\cellx5863\clvertalb\cellx6307\clvertalb\cellx6751\clvertalb\cellx7719\clvertalb\cellx7868\clvertalb\cellx8237\clvertalb\cellx9205\clvertalb\cellx9288\trrh248\row}}}
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx4303\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4452\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5864\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6308\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7720\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7869\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9207\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9288\trrh248
\pard\plain\intbl\li440\fi-220\cf1\f51\fs20\ql TRX518 program\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 1,415\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 1,038\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 377\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx4303\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4452\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5864\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6308\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7720\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7869\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9207\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9288\trrh248\row}}}
{\trowd\cellx4303\clvertalb\cellx4452\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx4895\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx5863\clvertalb\cellx6307\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx6751\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx7719\clvertalb\cellx7868\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx8237\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx9205\clvertalb\cellx9288\trrh248
\pard\plain\intbl\li660\fi-220\cf1\f51\fs20\ql Total research and development expenses\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr 6,790\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr 4,231\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr 2,559\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\cellx4303\clvertalb\cellx4452\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx4895\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx5863\clvertalb\cellx6307\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx6751\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx7719\clvertalb\cellx7868\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx8237\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx9205\clvertalb\cellx9288\trrh248\row}}}\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi308\cf1\f51\fs20\ql Research and development expenses were $6.8\~million for the three months ended March\~31, 2019, compared to $4.2\~million\plain\cf1\f51\fs20\ql for the three months ended March\~31, 2018.\~ The increase of $2.6\~million was primarily due to an increase of $2.4 million in\plain\cf1\f51\fs20\ql clinical trial costs due to an increase in patient enrollment, a $0.5 million increase in consulting fees associated with research and\plain\cf1\f51\fs20\ql development activities and an increase of $0.2 million in payroll and other related expenses due to an increase in headcount in\plain\cf1\f51\fs20\ql our research and development full time employees.\~ These increases were partially offset by a decrease of $0.5 million in\plain\cf1\f51\fs20\ql manufacturing costs related to clinical trial material due to timing of manufacturing campaigns.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\qc 29{\*\bkmkstart pb_29_023321_2897_12906402}{\*\bkmkend pb_29_023321_2897_12906402}\par\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par
\page\pard\plain\ul{\field{\*\fldinst HYPERLINK \\l "tableofcontents_12906402" }{\*\fldrslt\cf3\f51\fs20\ql Table of Contents}}\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\li1452\fi-220\cf1\f51\fs20\i\ql General and Administrative Expenses\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi308\cf1\f51\fs20\ql General and administrative expenses were $2.0 million for the three months ended March\~31, 2019, compared to $2.1 million\plain\cf1\f51\fs20\ql for the three months ended March\~31, 2018. The decrease of $0.1 million in general and administrative expenses was primarily\plain\cf1\f51\fs20\ql due to a decrease of $0.3 million in payroll and other related expenses due to a decrease in bonus expense in the three months\plain\cf1\f51\fs20\ql ending March\~31, 2019 as compared to the same period in 2018, partially offset by an increase of $0.2 million of stock based\plain\cf1\f51\fs20\ql compensation expense due to new stock options granted to employees and directors during the three months ended March\~31,\plain\cf1\f51\fs20\ql 2019.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\li990\fi88\cf1\f51\fs20\i\ql Interest Income\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi616\cf1\f51\fs20\ql We recorded interest income of $0.1 million and $0.1 million in the three months ended March\~31, 2019 and 2018,\plain\cf1\f51\fs20\ql respectively.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\li1452\fi-308\cf1\f51\fs20\i\ql Australian Research and Development Incentives\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi616\cf1\f51\fs20\ql We recorded R&D incentive income of $0.1 million and $0.6 million in the three months ended March\~31, 2019 and 2018,\plain\cf1\f51\fs20\ql respectively, based upon the applicable percentage of eligible research and development activities under the Australian Incentive\plain\cf1\f51\fs20\ql Program, which expenses included the cost of manufacturing clinical trial material.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi616\cf1\f51\fs20\ql We perform certain supporting research and development activity outside of Australia when there are no Australian\plain\cf1\f51\fs20\ql facilities that support the activity (\u8220?Overseas research and development activities\u8221?).\~ In October\~2017, the\plain\cf1\f51\fs20\ql Commonwealth of Australia issued us a favorable ruling on our Overseas research and development activities, considering such\plain\cf1\f51\fs20\ql activities to be eligible research and development activities under the Australian Incentive Program.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi616\cf1\f51\fs20\ql The R&D incentive receivable has been recorded as \u8220?Research and development incentive receivable\u8221? in the\plain\cf1\f51\fs20\ql condensed consolidated balance sheets.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\li1452\fi-308\cf1\f51\fs20\i\ql Foreign Currency Gains (loss)\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi616\cf1\f51\fs20\ql We recorded foreign currency gains (losses) of ($0.1) million during the three months ended March\~31, 2018.\~ We\plain\cf1\f51\fs20\ql recorded an immaterial amount of foreign currency gains during the three months ended March\~31, 2019. Foreign currency gains\plain\cf1\f51\fs20\ql and losses are due to changes in the Australian dollar exchange rate related to activities of the Australian entity.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\li1452\fi-308\cf1\f51\fs20\i\ql Gain on Change in Fair Value of Warrant Liability\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi638\cf1\f51\fs20\ql We recorded a loss on the change in fair value of the warrant liability during the three months ended March\~31, 2018 of\plain\cf1\f51\fs20\ql $4.9 million.\~ As of January 1, 2019, we adopted ASU\~No.\~2017-11,\plain\cf1\f51\fs20\i\ql Earnings Per Share (Topic\~260), Distinguishing Liabilities\plain\cf1\f51\fs20\i\ql from Equity (Topic\~480), and Derivatives and Hedging (Topic\~815)\plain\cf1\f51\fs20\ql \~ (\u8220?ASU\~2017-11\u8221?), which changes the\plain\cf1\f51\fs20\ql classification analysis of certain equity-linked financial instruments (or embedded features) with down round features. The\plain\cf1\f51\fs20\ql amendments require entities that present earnings per share (\u8220?EPS\u8221?) in accordance with Topic\~260 to recognize the\plain\cf1\f51\fs20\ql effect of the down round feature when triggered with the effect treated as a dividend and as a reduction of income available to\plain\cf1\f51\fs20\ql common shareholders in basic EPS.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi638\cf1\f51\fs20\ql We concluded that the 2017 Warrants now qualify for equity classification.\~ As the adoption of ASU 2017-11 provides\plain\cf1\f51\fs20\ql for a modified retrospective adoption, we applied the guidance to the 2017 Warrants by means of a cumulative-effect adjustment\plain\cf1\f51\fs20\ql as of January 1, 2019.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\ql Financial Position, Liquidity and Capital Resources{\*\bkmkstart financialpositionliquidityandcap}{\*\bkmkend financialpositionliquidityandcap}\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi638\cf1\f51\fs20\ql Since our inception, we have incurred significant operating losses. We have not yet commercialized any of our product\plain\cf1\f51\fs20\ql candidates, which are in various phases of clinical trials, and we do not expect to generate revenue from sales of any product for\plain\cf1\f51\fs20\ql several years, if at all. We have funded our operations to date with proceeds from the sale of common stock and preferred stock\plain\cf1\f51\fs20\ql and notes payable\u8212?related party.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi484\cf1\f51\fs20\ql As a result, we are not profitable and have incurred losses in every reporting period since our inception in 2011. For the\plain\cf1\f51\fs20\ql year ended December\~31, 2018, we reported a net loss of $23.1\~million, and had an accumulated deficit of $153.5\~million at\plain\cf1\f51\fs20\ql December\~31,\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\qc 30{\*\bkmkstart pb_30_015442_8724_12906402}{\*\bkmkend pb_30_015442_8724_12906402}\par\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par
\page\pard\plain\ul{\field{\*\fldinst HYPERLINK \\l "tableofcontents_12906402" }{\*\fldrslt\cf3\f51\fs20\ql Table of Contents}}\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\ql 2018.\~ For the three months ended March\~31, 2019, we reported a net loss of $8.6 million, and had an accumulated deficit of\plain\cf1\f51\fs20\ql $170.9 million at March\~31, 2019.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi484\cf1\f51\fs20\ql We expect our expenses to increase substantially in connection with our ongoing activities, particularly as we advance the\plain\cf1\f51\fs20\ql preclinical activities and clinical trials of our product candidates in development. In addition, we expect to incur additional costs\plain\cf1\f51\fs20\ql associated with operating as a public company.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi484\cf1\f51\fs20\ql Our expenses will also increase as we:\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\li594\fi-286\cf1\f53\fs20\ql ·\plain\li594\cf1\f51\fs6\ql \~\~\~\~\~\~\~\~\~\~\~\plain\li594\cf1\f51\fs20\ql pursue the clinical development of our most advanced product candidates, DKN-01 and TRX518;\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\li594\fi-286\cf1\f53\fs20\ql ·\plain\li594\cf1\f51\fs6\ql \~\~\~\~\~\~\~\~\~\~\~\plain\li594\cf1\f51\fs20\ql seek to identify and develop additional product candidates;\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\li594\fi-286\cf1\f53\fs20\ql ·\plain\li594\cf1\f51\fs6\ql \~\~\~\~\~\~\~\~\~\~\~\plain\li594\cf1\f51\fs20\ql maintain, expand and protect our intellectual property portfolio;\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\li594\fi-286\cf1\f53\fs20\ql ·\plain\li594\cf1\f51\fs6\ql \~\~\~\~\~\~\~\~\~\~\~\plain\li594\cf1\f51\fs20\ql expand our operational, financial and management systems and increase personnel, including personnel to support our\plain\li594\cf1\f51\fs20\ql clinical development, manufacturing and commercialization efforts and our operations as a public company; and\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\li594\fi-286\cf1\f53\fs20\ql ·\plain\li594\cf1\f51\fs6\ql \~\~\~\~\~\~\~\~\~\~\~\plain\li594\cf1\f51\fs20\ql increase our product liability and clinical trial insurance coverage as we initiate our clinical trials and commercialization\plain\li594\cf1\f51\fs20\ql efforts.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi594\cf1\f51\fs20\ql Additional funding may not be available at the time needed on commercially reasonable terms, if at all. As of March\~31,\plain\cf1\f51\fs20\ql 2019, we had cash and cash equivalents of $21.7 million. The foregoing matters give rise to a substantial doubt about our ability\plain\cf1\f51\fs20\ql to continue as a going concern for one year after our financial statements have been issued. We will seek additional funding\plain\cf1\f51\fs20\ql through public or private equity financings or government programs and will seek funding or development program cost-sharing\plain\cf1\f51\fs20\ql through collaboration agreements or licenses with larger pharmaceutical or biotechnology companies. If we do not obtain\plain\cf1\f51\fs20\ql additional funding or development program cost-sharing, we will be forced to delay, reduce or eliminate certain clinical trials or\plain\cf1\f51\fs20\ql research and development programs, reduce or eliminate discretionary operating expenses, and delay company and pipeline\plain\cf1\f51\fs20\ql expansion, which would adversely affect our business prospects. The inability to obtain funding, as and when needed, would have\plain\cf1\f51\fs20\ql a negative impact on our financial condition and ability to pursue our business strategies.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\i\ql Cash Flows{\*\bkmkstart cashflows_020211_12906402}{\*\bkmkend cashflows_020211_12906402}\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi616\cf1\f51\fs20\ql The following table summarizes our sources and uses of cash for each of the periods presented:\par\pard\plain\cf1\f51\fs20\ql \~
\par\pard\plain
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\pard\plain\intbl\cf1\f51\fs2\b\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs16\b\qc Three\~Months\~Ended\~March\~31,\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell{
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\pard\plain\intbl\cf1\f51\fs2\b\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs16\b\qc 2019\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs16\b\qc 2018\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell{
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\pard\plain\intbl\cf1\f51\fs2\b\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs16\b\qc (in\~thousands)\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell{
{\trowd\clvertalb\cellx4970\clvertalb\cellx5186\clvertalb\cellx8552\clvertalb\cellx8640\trrh198\row}}}
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\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\ql Cash used in operating activities\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr (6,868\cell\pard\plain\intbl\cf1\f51\fs20\ql )\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr (5,478\cell\pard\plain\intbl\cf1\f51\fs20\ql )\cell{
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\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\ql Cash provided by financing activities\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 12,322\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 15,005\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\cellx4970\clvertalb\cellx5186\clvertalb\cellx6647\clvertalb\cellx7091\clvertalb\cellx8552\clvertalb\cellx8640\trrh248\row}}}
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\pard\plain\intbl\li220\fi-220\cf1\f51\fs20\ql Effect of exchange rate changes on cash and cash\plain\intbl\li220\cf1\f51\fs20\ql equivalents\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr (29\cell\pard\plain\intbl\cf1\f51\fs20\ql )\cell\pard\plain\intbl\cf1\f51\fs20\qr 112\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx4970\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5186\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6647\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7091\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8552\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8640\trrh495\row}}}
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\pard\plain\intbl\li440\fi-220\cf1\f51\fs20\ql Net increase in cash and cash equivalents\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr 5,425\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr 9,639\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
{\trowd\cellx4970\clvertalb\cellx5186\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx5630\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx6647\clvertalb\cellx7091\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx7535\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx8552\clvertalb\cellx8640\trrh248\row}}}\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\qc 31{\*\bkmkstart pb_31_015452_7056_12906402}{\*\bkmkend pb_31_015452_7056_12906402}\par\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par
\page\pard\plain\ul{\field{\*\fldinst HYPERLINK \\l "tableofcontents_12906402" }{\*\fldrslt\cf3\f51\fs20\ql Table of Contents}}\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi440\cf1\f51\fs20\i\ql Operating activities.\plain\cf1\f51\fs20\ql Net cash used in operating activities for the three months ended March\~31, 2019 was primarily related\plain\cf1\f51\fs20\ql to our net loss from the operation of our business of $8.6 million and net changes in working capital, including a decrease of\plain\cf1\f51\fs20\ql $0.1 million in lease liabilities due to rent payments and an increase in research and development receivable of $0.1 million.\~\plain\cf1\f51\fs20\ql These changes were partially offset by an increase of $0.8 million in accounts payable and accrued expenses and noncash stock\plain\cf1\f51\fs20\ql based compensation expense and amortization on right-of-use assets of $0.9 million and $0.2 million, respectively.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi616\cf1\f51\fs20\ql Net cash used in operating activities for the three months ended March\~31, 2018 was primarily related to our net loss from\plain\cf1\f51\fs20\ql the operation of our business of $10.6 million and net changes in working capital, including a decrease of $0.4 million in\plain\cf1\f51\fs20\ql accounts payable and accrued expenses, partially offset by a noncash change in the fair value of the warrant liability of $4.9\plain\cf1\f51\fs20\ql million and noncash stock based compensation expense of $0.7 million.\~ The decrease in accounts payable and accrued expenses\plain\cf1\f51\fs20\ql was due to timing of vendor payments.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi616\cf1\f51\fs20\i\ql Investing Activities.\plain\cf1\f51\fs20\ql \~There were no investing activities during the three months ended March\~31, 2019 and 2018.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi528\cf1\f51\fs20\i\ql Financing Activities.\plain\cf1\f51\fs20\ql \~Net cash provided by financing activities for the three months ended March\~31, 2019 consisted of\plain\cf1\f51\fs20\ql $12.3 million in proceeds from the issuance of common stock in connection with the 2019 Public Offering, net of underwriter\plain\cf1\f51\fs20\ql commissions and discounts.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi528\cf1\f51\fs20\ql Net cash provided by financing activities for the three months ended March\~31, 2018 consisted of $15.0 million in proceeds\plain\cf1\f51\fs20\ql from the issuance of common stock in connection with the March\~2018 public offering, net of underwriter commissions and\plain\cf1\f51\fs20\ql discounts.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\ql Off-Balance Sheet Arrangements\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi748\cf1\f51\fs20\ql We did not have during the periods presented, and we do not currently have, any off-balance sheet arrangements, as\plain\cf1\f51\fs20\ql defined in the rules\~and regulations of the SEC.\par\pard\plain\cf1\f51\fs20\ql \~{\*\bkmkstart item_1_3_3}{\*\bkmkend item_1_3_3}\par\pard\plain\cf1\f51\fs20\b\ql Item 3. Quantitative and Qualitative Disclosures about Market Risk{\*\bkmkstart item3_quantitativeandqualitative}{\*\bkmkend item3_quantitativeandqualitative}\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi748\cf1\f51\fs20\ql Not Applicable.\par\pard\plain\cf1\f51\fs20\ql \~{\*\bkmkstart item_1_3_4}{\*\bkmkend item_1_3_4}\par\pard\plain\cf1\f51\fs20\b\ql Item 4. Controls and Procedures{\*\bkmkstart item4_controlsandprocedures_0202}{\*\bkmkend item4_controlsandprocedures_0202}\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\i\ql Evaluation of Disclosure Controls and Procedures\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi748\cf1\f51\fs20\ql We maintain disclosure controls and procedures that are designed to ensure that information required to be disclosed in\plain\cf1\f51\fs20\ql the reports that we file or submit under the Securities and Exchange Act of 1934 is (1)\~recorded, processed, summarized, and\plain\cf1\f51\fs20\ql reported within the time periods specified in the SEC\u8217?s rules\~and forms and (2)\~accumulated and communicated to our\plain\cf1\f51\fs20\ql management, including our President and Chief Executive Officer, who is our principal executive officer, and Chief Financial\plain\cf1\f51\fs20\ql Officer, who is also our principal financial and accounting officer, as appropriate, to allow timely decisions regarding required\plain\cf1\f51\fs20\ql disclosure.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi616\cf1\f51\fs20\ql As of March\~31, 2019, our management, with the participation of our principal executive officer and principal financial\plain\cf1\f51\fs20\ql and accounting officer, evaluated the effectiveness of our disclosure controls and procedures (as defined in Rules\~13a-15(e)\~and\plain\cf1\f51\fs20\ql 15d-15(e)\~under the Securities and Exchange Act of 1934) using the criteria set forth by the Committee of Sponsoring\plain\cf1\f51\fs20\ql Organizations of the Treadway Commission (COSO)\~in Internal Control\u8212?Integrated Framework (2013 Framework). Our\plain\cf1\f51\fs20\ql management recognizes that any controls and procedures, no matter how well designed and operated, can provide only reasonable\plain\cf1\f51\fs20\ql assurance of achieving their objectives, and management necessarily applies its judgment in evaluating the cost-benefit\plain\cf1\f51\fs20\ql relationship of possible controls and procedures. Our principal executive officer and principal financial and accounting officer\plain\cf1\f51\fs20\ql have concluded based upon the evaluation described above that, as of March\~31, 2019, our disclosure controls and procedures\plain\cf1\f51\fs20\ql were effective to ensure that information required to be disclosed by it in reports the Company files or submits under the\plain\cf1\f51\fs20\ql Exchange Act is recorded, processed, summarized and reported within the time periods specified in the rules\~and forms of the\plain\cf1\f51\fs20\ql SEC, and that such material information is accumulated and communicated to the Company\u8217?s management, including its\plain\cf1\f51\fs20\ql Principal Executive Officer and Principal Financial Officer, to allow timely decisions regarding required disclosure.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\qc 32{\*\bkmkstart pb_32_015737_5335_12906402}{\*\bkmkend pb_32_015737_5335_12906402}\par\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par
\page\pard\plain\ul{\field{\*\fldinst HYPERLINK \\l "tableofcontents_12906402" }{\*\fldrslt\cf3\f51\fs20\ql Table of Contents}}\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\i\ql Changes in Internal Control over Financial Reporting{\*\bkmkstart changesininternalcontroloverfina}{\*\bkmkend changesininternalcontroloverfina}\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi748\cf1\f51\fs20\ql During the three months ended March\~31, 2019, there were no changes in our internal control over financial reporting (as\plain\cf1\f51\fs20\ql defined in Rule\~13a-15(f)\~under the Exchange Act) that materially affected, or are reasonably likely to affect, internal control\plain\cf1\f51\fs20\ql over financial reporting.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\qc 33{\*\bkmkstart pb_33_015750_5796_12906402}{\*\bkmkend pb_33_015750_5796_12906402}\par\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par
\page\pard\plain\ul{\field{\*\fldinst HYPERLINK \\l "tableofcontents_12906402" }{\*\fldrslt\cf3\f51\fs20\ql Table of Contents}}\par\pard\plain\cf1\f51\fs20\ql \~{\*\bkmkstart part_1_2_2}{\*\bkmkend part_1_2_2}\par\pard\plain\cf1\f51\fs20\b\qc Part\~II \u8212? OTHER INFORMATION{\*\bkmkstart partiiotherinformation_020155_12}{\*\bkmkend partiiotherinformation_020155_12}\par\pard\plain\cf1\f51\fs20\ql \~{\*\bkmkstart item_1_3_5}{\*\bkmkend item_1_3_5}\par\pard\plain\cf1\f51\fs20\b\ql Item 1. Legal Proceedings{\*\bkmkstart item1_legalproceedings_020144_12}{\*\bkmkend item1_legalproceedings_020144_12}\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi748\cf1\f51\fs20\ql None.\par\pard\plain\cf1\f51\fs20\ql \~{\*\bkmkstart item_1_3_6}{\*\bkmkend item_1_3_6}\par\pard\plain\cf1\f51\fs20\b\ql Item 1A. Risk Factors{\*\bkmkstart item1a_riskfactors_020147_129064}{\*\bkmkend item1a_riskfactors_020147_129064}\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi748\cf1\f51\fs20\ql An investment in our ordinary shares involves a high degree of risk. In addition to the other information contained\plain\cf1\f51\fs20\ql elsewhere in this report, you should carefully consider the risk factors discussed in Part\~I,\~Item 1A \u8220?Risk Factors\u8221? in\plain\cf1\f51\fs20\ql our Annual Report on Form\~10-K for the year ended December\~31, 2018 as filed with the SEC on April\~1, 2019, which could\plain\cf1\f51\fs20\ql materially affect our business, financial condition, operating results or cash flows. We operate in a dynamic and rapidly changing\plain\cf1\f51\fs20\ql industry that involves numerous risks and uncertainties. In addition to those risk factors, you should consider the following:\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\qc Risks Related to Leap\u8217?s Financial Position and Capital Needs{\*\bkmkstart risksrelatedtoleapsfinancialposi}{\*\bkmkend risksrelatedtoleapsfinancialposi}\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\i\ql We have incurred significant losses since our inception and anticipate that we will continue to incur losses in the future.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi484\cf1\f51\fs20\ql We are a clinical-stage biopharmaceutical company. Investment in biopharmaceutical product development is highly\plain\cf1\f51\fs20\ql speculative because it entails substantial upfront capital expenditures and significant risk that our two product candidates,\plain\cf1\f51\fs20\ql DKN-01 and TRX518, or any other products will fail to gain regulatory approval or become commercially viable. We have only\plain\cf1\f51\fs20\ql two clinical-stage product candidates, which are at the early stages of clinical development. We do not have any products\plain\cf1\f51\fs20\ql approved by regulatory authorities for marketing and have not generated any revenue from product sales. We incur significant\plain\cf1\f51\fs20\ql research, development and other expenses related to our ongoing operations.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi484\cf1\f51\fs20\ql As a result, we are not profitable and have incurred losses in every reporting period since our inception in 2011. For the\plain\cf1\f51\fs20\ql year ended December\~31, 2018, we reported a net loss of $23.1\~million, and had an accumulated deficit of $153.5\~million at\plain\cf1\f51\fs20\ql December\~31, 2018.\~ For the three months ended March\~31, 2019, we reported a net loss of $8.6 million, and had an accumulated\plain\cf1\f51\fs20\ql deficit of $170.9 million at March\~31, 2019.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi484\cf1\f51\fs20\ql We expect to continue to incur significant expenses and operating losses for the foreseeable future. We anticipate these\plain\cf1\f51\fs20\ql losses to increase as we continue the research and development of, and seek regulatory approvals for DKN-01 and TRX518, and\plain\cf1\f51\fs20\ql we potentially begin to commercialize DKN-01 and TRX518, if they receive regulatory approval. We may encounter unforeseen\plain\cf1\f51\fs20\ql expenses, difficulties, complications, delays and other unknown factors that may adversely affect our business. The size of our\plain\cf1\f51\fs20\ql future net losses will depend, in part, on the rate of future growth of our expenses and our ability to generate revenues. If either\plain\cf1\f51\fs20\ql or both of DKN-01 or TRX518 fails in clinical trials or does not gain regulatory approval, or if approved, fails to achieve\plain\cf1\f51\fs20\ql market acceptance, we may never become profitable. Even if we achieve profitability in the future, we may not be able to sustain\plain\cf1\f51\fs20\ql profitability in subsequent periods.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\i\ql Our management as of March\~31, 2019 has concluded that due to our need for additional capital, and the uncertainties\plain\cf1\f51\fs20\b\i\ql surrounding our ability to raise such funding, substantial doubt exists as to our ability to continue as a going concern.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi484\cf1\f51\fs20\ql Our financial statements for the quarter ended March\~31, 2019 were prepared assuming that we will continue as a going\plain\cf1\f51\fs20\ql concern.\~ The going concern basis of presentation assumes that we will continue in operation for the foreseeable future and will\plain\cf1\f51\fs20\ql be able to realize our assets and discharge our liabilities and commitments in the normal course of business and do not include\plain\cf1\f51\fs20\ql any adjustments to reflect the possible future effects on the recoverability and classification of assets or the amounts and\plain\cf1\f51\fs20\ql classification of liabilities that may result from our inability to continue as a going concern. Our management concluded as of\plain\cf1\f51\fs20\ql March\~31, 2019 that due to our need for additional capital and the uncertainties surrounding our ability to raise such funding,\plain\cf1\f51\fs20\ql substantial doubt exists as to our ability to continue as a going concern for a period from one year after our financial statements\plain\cf1\f51\fs20\ql have been issued.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi484\cf1\f51\fs20\ql We have based these estimates on assumptions that may prove to be wrong, and we could exhaust our available financial\plain\cf1\f51\fs20\ql resources sooner than we currently anticipate.\~ We may be forced to reduce our operating expenses and raise additional funds to\plain\cf1\f51\fs20\ql meet our working capital needs, principally through the additional sales of our securities or debt financings.\~ However, we cannot\plain\cf1\f51\fs20\ql guarantee that we will be able to obtain sufficient additional funds when needed or that such funds, if available, will be\plain\cf1\f51\fs20\ql obtainable on terms satisfactory to us.\~ If we are unable to raise sufficient additional capital or complete a strategic transaction,\plain\cf1\f51\fs20\ql we may be unable to continue to fund our operations, develop our product candidates, or realize value from our assets and\plain\cf1\f51\fs20\ql discharge our liabilities in the normal course of business.\~ If we cannot raise sufficient funds, we may have to liquidate our\plain\cf1\f51\fs20\ql assets, and might realize significantly less than the values at which they are carried on our financial statements, and stockholders\plain\cf1\f51\fs20\ql may lose all or part of their investment in our common stock.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\qc 34{\*\bkmkstart pb_34_015840_2897_12906402}{\*\bkmkend pb_34_015840_2897_12906402}\par\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par
\page\pard\plain\ul{\field{\*\fldinst HYPERLINK \\l "tableofcontents_12906402" }{\*\fldrslt\cf3\f51\fs20\ql Table of Contents}}\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\i\ql We will require additional capital to fund our operations and if we fail to obtain necessary financing, we may be unable to\plain\cf1\f51\fs20\b\i\ql complete the development and potential commercialization of DKN-01 or TRX518 or acquire other products.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi484\cf1\f51\fs20\ql Our operations have consumed substantial amounts of cash since inception. As of March\~31, 2019, we had cash and cash\plain\cf1\f51\fs20\ql equivalents of $21.7 million.\~ We expect to continue to spend substantial amounts to advance the clinical development of\plain\cf1\f51\fs20\ql DKN-01 and TRX518.\~ We will require additional capital for the further development. If we are unable to raise capital when\plain\cf1\f51\fs20\ql needed or at all, we could be forced to delay, reduce or eliminate our research and development programs or any future\plain\cf1\f51\fs20\ql commercialization efforts.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi484\cf1\f51\fs20\ql Our future funding requirements, both near and long-term, will depend on many factors, including, but not limited to the:\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\li594\fi-286\cf1\f53\fs20\ql ·\plain\li594\cf1\f51\fs6\ql \~\~\~\~\~\~\~\~\~\~\~\plain\li594\cf1\f51\fs20\ql initiation, progress, timing, costs and results of pre-clinical studies and clinical trials for our product candidates;\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\li594\fi-286\cf1\f53\fs20\ql ·\plain\li594\cf1\f51\fs6\ql \~\~\~\~\~\~\~\~\~\~\~\plain\li594\cf1\f51\fs20\ql costs and timing of additional clinical trial and commercial manufacturing activities;\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\li594\fi-286\cf1\f53\fs20\ql ·\plain\li594\cf1\f51\fs6\ql \~\~\~\~\~\~\~\~\~\~\~\plain\li594\cf1\f51\fs20\ql clinical development plans we establish for DKN-01, TRX518, and any other future product candidates;\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\li594\fi-286\cf1\f53\fs20\ql ·\plain\li594\cf1\f51\fs6\ql \~\~\~\~\~\~\~\~\~\~\~\plain\li594\cf1\f51\fs20\ql number and characteristics of any new product candidates that we in-license and develop;\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\li594\fi-286\cf1\f53\fs20\ql ·\plain\li594\cf1\f51\fs6\ql \~\~\~\~\~\~\~\~\~\~\~\plain\li594\cf1\f51\fs20\ql outcome, timing and cost of regulatory review by the FDA and comparable foreign regulatory authorities, including the\plain\li594\cf1\f51\fs20\ql potential for the FDA or comparable foreign regulatory authorities to require that we perform more studies than those that\plain\li594\cf1\f51\fs20\ql we currently expect;\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\li594\fi-286\cf1\f53\fs20\ql ·\plain\li594\cf1\f51\fs6\ql \~\~\~\~\~\~\~\~\~\~\~\plain\li594\cf1\f51\fs20\ql costs of filing, prosecuting, defending and enforcing any patent claims and maintaining and enforcing other intellectual\plain\li594\cf1\f51\fs20\ql property rights;\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\li594\fi-286\cf1\f53\fs20\ql ·\plain\li594\cf1\f51\fs6\ql \~\~\~\~\~\~\~\~\~\~\~\plain\li594\cf1\f51\fs20\ql effect of competing product candidates and market developments; and\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\li594\fi-286\cf1\f53\fs20\ql ·\plain\li594\cf1\f51\fs6\ql \~\~\~\~\~\~\~\~\~\~\~\plain\li594\cf1\f51\fs20\ql costs and timing of establishing sales, marketing and distribution capabilities for any product candidates for which we\plain\li594\cf1\f51\fs20\ql may receive regulatory approval.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi484\cf1\f51\fs20\ql If we are unable to fund our operations or otherwise capitalize on our business opportunities due to a lack of capital, our\plain\cf1\f51\fs20\ql ability to become profitable will be compromised.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\i\ql Raising additional capital may cause dilution to our existing stockholders, restrict our operations or require us to relinquish\plain\cf1\f51\fs20\b\i\ql rights to our product candidates.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi484\cf1\f51\fs20\ql Until we can generate substantial revenue from product sales, if ever, we expect to seek additional capital through a\plain\cf1\f51\fs20\ql combination of private and public equity offerings, debt financings, strategic collaborations and alliances and licensing\plain\cf1\f51\fs20\ql arrangements. To the extent that we raise additional capital through the sale of equity or convertible debt securities, the\plain\cf1\f51\fs20\ql ownership interests of existing stockholders will be diluted, and the terms may include liquidation or other preferences that\plain\cf1\f51\fs20\ql adversely affect the rights of existing stockholders. Debt financing, if available, may involve agreements that include liens or\plain\cf1\f51\fs20\ql other restrictive covenants limiting our ability to take important actions, such as incurring additional debt, making capital\plain\cf1\f51\fs20\ql expenditures or declaring dividends. If we are unable to raise additional funds through equity or debt financing when needed, we\plain\cf1\f51\fs20\ql may be required to delay, limit, reduce or terminate our product development or commercialization efforts or grant rights to\plain\cf1\f51\fs20\ql develop and market our product candidates that we would otherwise prefer to develop and market ourselves. If we raise\plain\cf1\f51\fs20\ql additional funds through strategic collaborations and alliances or licensing arrangements with third parties, we may have to\plain\cf1\f51\fs20\ql relinquish valuable rights to our product candidates in particular countries, or grant licenses on terms that are not favorable to us.\par\pard\plain\cf1\f51\fs20\ql \~{\*\bkmkstart item_1_3_7}{\*\bkmkend item_1_3_7}\par\pard\plain\cf1\f51\fs20\b\ql Item 2. Unregistered Sales of Equity Securities and Use of Proceeds{\*\bkmkstart item2_unregisteredsalesofequitys}{\*\bkmkend item2_unregisteredsalesofequitys}\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi748\cf1\f51\fs20\ql None.\par\pard\plain\cf1\f51\fs20\ql \~{\*\bkmkstart item_1_3_8}{\*\bkmkend item_1_3_8}\par\pard\plain\cf1\f51\fs20\b\ql Item 3. Defaults Upon Senior Securities{\*\bkmkstart item3_defaultsuponseniorsecuriti}{\*\bkmkend item3_defaultsuponseniorsecuriti}\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi748\cf1\f51\fs20\ql None.\par\pard\plain\cf1\f51\fs20\ql \~{\*\bkmkstart item_1_3_9}{\*\bkmkend item_1_3_9}\par\pard\plain\cf1\f51\fs20\b\ql Item 4. Mine Safety Disclosures{\*\bkmkstart item4_minesafetydisclosures_0201}{\*\bkmkend item4_minesafetydisclosures_0201}\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi748\cf1\f51\fs20\ql None.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\qc 35{\*\bkmkstart pb_35_020024_3020_12906402}{\*\bkmkend pb_35_020024_3020_12906402}\par\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par
\page\pard\plain\ul{\field{\*\fldinst HYPERLINK \\l "tableofcontents_12906402" }{\*\fldrslt\cf3\f51\fs20\ql Table of Contents}}\par\pard\plain\cf1\f51\fs20\ql \~{\*\bkmkstart item_1_3_10}{\*\bkmkend item_1_3_10}\par\pard\plain\cf1\f51\fs20\b\ql Item 5. Other Information{\*\bkmkstart item5_otherinformation_020124_12}{\*\bkmkend item5_otherinformation_020124_12}\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi748\cf1\f51\fs20\ql None.\par\pard\plain\cf1\f51\fs20\ql \~{\*\bkmkstart item_1_3_11}{\*\bkmkend item_1_3_11}\par\pard\plain\cf1\f51\fs20\b\ql Item 6. Exhibits{\*\bkmkstart item6_exhibits_020127_12906402}{\*\bkmkend item6_exhibits_020127_12906402}\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi748\cf1\f51\fs20\ql See the Exhibit\~Index immediately prior to the signature page\~to this Quarterly Report on Form\~10-Q for a list of\plain\cf1\f51\fs20\ql exhibits filed or furnished with this report, which Exhibit\~Index is incorporated herein by reference.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\qc EXHIBIT\~INDEX{\*\bkmkstart exhibitindex_020245_12906402}{\*\bkmkend exhibitindex_020245_12906402}\par\pard\plain\cf1\f51\fs20\ql \~
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\pard\plain\intbl\cf1\f51\fs20\ql 32.1\plain\intbl\cf1\f51\fs20\ql \u177?**\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\ul{\field{\*\fldinst HYPERLINK \\l "exhibit32_1_110927_12906402" }{\*\fldrslt\cf3\f51\fs20\ql Principal Executive Officer Certification and Principal Financial Officer Certification Pursuant to 18 U.S.C.}}\plain\intbl\ul{\field{\*\fldinst HYPERLINK \\l "exhibit32_1_110927_12906402" }{\*\fldrslt\cf3\f51\fs20\ql Section\~1350, as Adopted Pursuant to Section\~906 of the Sarbanes-Oxley Act of 2002.}}\cell{
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\pard\plain\intbl\cf1\f51\fs20\ql 101 \u177?\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql The following materials from Leap Therapeutics,\~Inc.\u8217?s Quarterly Report on Form\~10-Q for the quarter\plain\intbl\cf1\f51\fs20\ql ended March\~31, 2019, formatted in XBRL (Extensible Business Reporting Language): (i)\~Condensed\plain\intbl\cf1\f51\fs20\ql Consolidated Balance Sheets at March\~31, 2019 and December\~31, 2018, (ii)\~Condensed Consolidated Statements\plain\intbl\cf1\f51\fs20\ql of Operations for the three months ended March\~31, 2019 and March\~31, 2018, (iii)\~Condensed Consolidated\plain\intbl\cf1\f51\fs20\ql Statements of Comprehensive Loss for the three months ended March\~31, 2019 and March\~31, 2018,\plain\intbl\cf1\f51\fs20\ql (iv)\~Condensed Consolidated Statements of Shareholders\u8217? Equity at March\~31, 2019 and December\~31,\plain\intbl\cf1\f51\fs20\ql 2018 (v)\~Condensed Consolidated Statements of Cash Flows for the three months ended March\~31, 2019 and\plain\intbl\cf1\f51\fs20\ql March\~31, 2018, and (vi)\~Notes to Condensed Consolidated Financial Statements, tagged as blocks of text.\cell{
{\trowd\cellx1080\clvertalb\cellx1403\cellx10800\trrh1980\row}}}\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par\par\pard\plain\fi44\cf1\f51\fs20\ql \u177? Filed herewith.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\ql ** This exhibit shall not be deemed \u8220?filed\u8221? for purposes of Section\~18 of the Securities Exchange Act of 1934 or\plain\cf1\f51\fs20\ql otherwise subject to the liabilities of that Section, nor shall it be deemed incorporated by reference in any filings under the\plain\cf1\f51\fs20\ql Securities Act of 1933 or the Securities and Exchange Act of 1934, whether made before or after the date hereof and irrespective\plain\cf1\f51\fs20\ql of any general incorporation language in any filing.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\qc 36{\*\bkmkstart pb_36_020302_7748_12906402}{\*\bkmkend pb_36_020302_7748_12906402}\par\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par
\page\pard\plain\ul{\field{\*\fldinst HYPERLINK \\l "tableofcontents_12906402" }{\*\fldrslt\cf3\f51\fs20\ql Table of Contents}}\par\pard\plain\cf1\f51\fs20\ql \~{\*\bkmkstart part_1_2_3}{\*\bkmkend part_1_2_3}\par\pard\plain\cf1\f51\fs20\b\ul\qc SIGNATURES\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\ql Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its\plain\cf1\f51\fs20\ql behalf by the undersigned, thereunto duly authorized.\par\pard\plain\cf1\f51\fs20\ql \~
\par\pard\plain
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\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql LEAP THERAPEUTICS,\~INC.\cell{
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\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell{
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\pard\plain\intbl\cf1\f51\fs20\ql Date:\cell\pard\plain\intbl\cf1\f51\fs20\ql May 15, 2019\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql By:\cell\pard\plain\intbl\cf1\f51\fs20\ql /s/ Christopher K. Mirabelli, Ph.D.\cell{
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\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql Christopher K. Mirabelli, Ph.D.\cell{
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\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql President, Chief Executive Officer and Chairman\plain\intbl\cf1\f51\fs20\ql of the Board of Directors\cell{
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\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell{
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\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql (Principal Executive Officer)\cell{
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\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell{
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\pard\plain\intbl\cf1\f51\fs20\ql Date:\cell\pard\plain\intbl\cf1\f51\fs20\ql May 15, 2019\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql By:\cell\pard\plain\intbl\cf1\f51\fs20\ql /s/ Douglas E. Onsi\cell{
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\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql Douglas E. Onsi\cell{
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\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql Chief Financial Officer, General Counsel,\plain\intbl\cf1\f51\fs20\ql Treasurer and Secretary\cell{
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\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql (Principal Financial Officer and Principal\plain\intbl\cf1\f51\fs20\ql Accounting Officer)\cell{
{\trowd\cellx5124\cellx5334\cellx6708\cellx10800\trrh495\row}}}\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\qc 37{\*\bkmkstart pb_37_020318_141_12906402}{\*\bkmkend pb_37_020318_141_12906402}\par\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par
\page{\*\bkmkstart doc_1_2}{\*\bkmkend doc_1_2}\par\pard\plain\cf1\f51\fs20\b\qr Exhibit\~31.1{\*\bkmkstart exhibit31_1_110626_12906402}{\*\bkmkend exhibit31_1_110626_12906402}\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\qc CERTIFICATION PURSUANT TO\par\pard\plain\cf1\f51\fs20\b\qc SECURITIES EXCHANGE ACT RULES 13a-14(a)\~AND 15d-14(a)\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\ql I, Christopher K. Mirabelli, Ph.D., certify that:\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\ql 1.\~I have reviewed this Quarterly Report on Form\~10-Q of Leap Therapeutics,\~Inc.;\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\ql 2.\~Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact\plain\cf1\f51\fs20\ql necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading\plain\cf1\f51\fs20\ql with respect to the period covered by this report;\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\ql 3.\~Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all\plain\cf1\f51\fs20\ql material respects the financial condition, results of operations and cash flows of the registrant as of, and for, the periods\plain\cf1\f51\fs20\ql presented in this report;\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\ql 4.\~The registrant\u8217?s other certifying officer and I are responsible for establishing and maintaining disclosure controls and\plain\cf1\f51\fs20\ql procedures (as defined in Exchange Act Rules\~13a-15(e)\~and 15d-15(e)) and internal control over financial reporting (as defined\plain\cf1\f51\fs20\ql in Exchange Act Rules\~13a-15(f)\~and 15d-15(f)) for the registrant and have:\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\ql a)\~Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our\plain\cf1\f51\fs20\ql supervision, to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to\plain\cf1\f51\fs20\ql us by others within those entities, particularly during the period in which this report is being prepared;\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\ql b)\~Designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed\plain\cf1\f51\fs20\ql under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of\plain\cf1\f51\fs20\ql financial statements for external purposes in accordance with generally accepted accounting principles;\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\ql c)\~Evaluated the effectiveness of the registrant\u8217?s disclosure controls and procedures and presented in this report our\plain\cf1\f51\fs20\ql conclusions about the effectiveness of the disclosure controls and procedures as of the end of the period covered by this report\plain\cf1\f51\fs20\ql based on such evaluation; and\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\ql d)\~Disclosed in this report any change in the registrant\u8217?s internal control over financial reporting that occurred during the\plain\cf1\f51\fs20\ql registrant\u8217?s most recent fiscal quarter (the registrant\u8217?s fourth fiscal quarter in the case of an annual report) that has\plain\cf1\f51\fs20\ql materially affected, or is reasonably likely to materially affect, the registrant\u8217?s internal control over financial reporting; and\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\ql 5.\~The registrant\u8217?s other certifying officer and I have disclosed, based on our most recent evaluation of internal control\plain\cf1\f51\fs20\ql over financial reporting, to the registrant\u8217?s auditors and the audit committee of the registrant\u8217?s Board of Directors\plain\cf1\f51\fs20\ql (or persons performing the equivalent functions):\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\ql a)\~All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting\plain\cf1\f51\fs20\ql which are reasonably likely to adversely affect the registrant\u8217?s ability to record, process, summarize and report financial\plain\cf1\f51\fs20\ql information; and\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\ql b)\~Any fraud, whether or not material, that involves management or other employees who have a significant role in the\plain\cf1\f51\fs20\ql registrant\u8217?s internal control over financial reporting.\par\pard\plain\cf1\f51\fs20\qc \~
\par\pard\plain
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\pard\plain\intbl\cf1\f51\fs20\ql May 15, 2019\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql /s/\~CHRISTOPHER K. MIRABELLI, PH.D.\cell{
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\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell{
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\pard\plain\intbl\cf1\f51\fs20\ql Date\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql Christopher K. Mirabelli, Ph.D.\cell{
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\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql Chief Executive Officer, President and Chairman of the Board\cell{
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{\trowd\cellx5328\cellx5580\cellx10800\trrh248
\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql (Principal Executive Officer)\cell{
{\trowd\cellx5328\cellx5580\cellx10800\trrh248\row}}}\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par
\page{\*\bkmkstart doc_1_3}{\*\bkmkend doc_1_3}\par\pard\plain\cf1\f51\fs20\b\qr Exhibit\~31.2{\*\bkmkstart exhibit31_2_110749_12906402}{\*\bkmkend exhibit31_2_110749_12906402}\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\qc CERTIFICATION PURSUANT TO\par\pard\plain\cf1\f51\fs20\b\qc SECURITIES EXCHANGE ACT RULES 13a-14(a)\~AND 15d-14(a)\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\ql I, Douglas E. Onsi, certify that:\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\ql 1.\~I have reviewed this Quarterly Report on Form\~10-Q of Leap Therapeutics,\~Inc.;\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\ql 2.\~Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact\plain\cf1\f51\fs20\ql necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading\plain\cf1\f51\fs20\ql with respect to the period covered by this report;\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\ql 3.\~Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all\plain\cf1\f51\fs20\ql material respects the financial condition, results of operations and cash flows of the registrant as of, and for, the periods\plain\cf1\f51\fs20\ql presented in this report;\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\ql 4.\~The registrant\u8217?s other certifying officer and I are responsible for establishing and maintaining disclosure controls and\plain\cf1\f51\fs20\ql procedures (as defined in Exchange Act Rules\~13a-15(e)\~and 15d-15(e)) \~and internal control over financial reporting (as defined\plain\cf1\f51\fs20\ql in Exchange Act Rules\~13a-15(f)\~and 15d-15(f))\~ for the registrant and have:\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\ql a)\~Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our\plain\cf1\f51\fs20\ql supervision, to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to\plain\cf1\f51\fs20\ql us by others within those entities, particularly during the period in which this report is being prepared;\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\ql b)\~Designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed\plain\cf1\f51\fs20\ql under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of\plain\cf1\f51\fs20\ql financial statements for external purposes in accordance with generally accepted accounting principles;\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\ql c)\~Evaluated the effectiveness of the registrant\u8217?s disclosure controls and procedures and presented in this report our\plain\cf1\f51\fs20\ql conclusions about the effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report\plain\cf1\f51\fs20\ql based on such evaluation; and\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\ql d)\~Disclosed in this report any change in the registrant\u8217?s internal control over financial reporting that occurred during the\plain\cf1\f51\fs20\ql registrant\u8217?s most recent fiscal quarter (the registrant\u8217?s fourth fiscal quarter in the case of an annual report) that has\plain\cf1\f51\fs20\ql materially affected, or is reasonably likely to materially affect, the registrant\u8217?s internal control over financial reporting; and\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\ql 5.\~The registrant\u8217?s other certifying officer and I have disclosed, based on our most recent evaluation of internal control\plain\cf1\f51\fs20\ql over financial reporting, to the registrant\u8217?s auditors and the audit committee of the registrant\u8217?s Board of Directors\plain\cf1\f51\fs20\ql (or persons performing the equivalent functions):\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\ql a)\~All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting\plain\cf1\f51\fs20\ql which are reasonably likely to adversely affect the registrant\u8217?s ability to record, process, summarize and report financial\plain\cf1\f51\fs20\ql information; and\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\ql b)\~Any fraud, whether or not material, that involves management or other employees who have a significant role in the\plain\cf1\f51\fs20\ql registrant\u8217?s internal control over financial reporting.\par\pard\plain\cf1\f51\fs20\qc \~
\par\pard\plain
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\pard\plain\intbl\cf1\f51\fs20\ql May 15, 2019\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql /s/\~DOUGLAS E. ONSI\cell{
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\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell{
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\pard\plain\intbl\cf1\f51\fs20\ql Date\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql Douglas E. Onsi\cell{
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\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql Chief Financial Officer, General Counsel, Treasurer and\plain\intbl\cf1\f51\fs20\ql Secretary\cell{
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\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell{
{\trowd\cellx5148\cellx5436\cellx10800\trrh248\row}}}
{\trowd\cellx5148\cellx5436\cellx10800\trrh248
\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql (Principal Financial Officer and Principal Accounting Officer)\cell{
{\trowd\cellx5148\cellx5436\cellx10800\trrh248\row}}}\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par
\page{\*\bkmkstart doc_1_4}{\*\bkmkend doc_1_4}\par\pard\plain\cf1\f51\fs20\b\qr Exhibit\~32.1{\*\bkmkstart exhibit32_1_110927_12906402}{\*\bkmkend exhibit32_1_110927_12906402}\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\qc CERTIFICATIONS PURSUANT TO\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\qc 18 U.S.C. SECTION\~1350,\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\qc AS ADOPTED PURSUANT TO\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\qc SECTION\~906 OF THE SARBANES-OXLEY ACT OF\~2002\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\fi616\cf1\f51\fs20\ql In connection with the Quarterly Report of Leap Therapeutics,\~Inc. (the \u8220?Corporation\u8221?) on Form\~10-Q for the\plain\cf1\f51\fs20\ql quarter ended March 31, 2019, as filed with the Securities and Exchange Commission on the date hereof (the\plain\cf1\f51\fs20\ql \u8220?Report\u8221?),\~I, Christopher\~K. Mirabelli, Ph.D., as Chief Executive Officer, President and Chairman of the Board of\plain\cf1\f51\fs20\ql the Corporation, and I, Douglas\~E. Onsi, the Chief Financial Officer, General Counsel, Treasurer and Secretary of the\plain\cf1\f51\fs20\ql Corporation, hereby certify, pursuant to 18 U.S.C. Section\~1350, as adopted pursuant to Section\~906 of the Sarbanes-Oxley Act\plain\cf1\f51\fs20\ql of 2002, that, to my knowledge:\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\ql (1)\~The Report fully complies with the requirements of Section\~13(a)\~or 15(d)\~of the Securities Exchange Act of 1934; and\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\ql (2)\~The information contained in the Report fairly presents, in all material respects, the financial condition and results of\plain\cf1\f51\fs20\ql operations of the Corporation.\par\pard\plain\cf1\f51\fs20\qc \~
\par\pard\plain
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\pard\plain\intbl\cf1\f51\fs20\ql Date: May 15, 2019\cell\pard\plain\intbl\cf1\f51\fs20\ql By:\cell\pard\plain\intbl\cf1\f51\fs20\ql /s/\~CHRISTOPHER K. MIRABELLI, PH.D.\cell{
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{\trowd\cellx5220\cellx5688\cellx10800\trrh248
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell{
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{\trowd\cellx5220\cellx5688\cellx10800\trrh248
\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql Christopher K. Mirabelli, Ph.D.\cell{
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{\trowd\cellx5220\cellx5688\cellx10800\trrh495
\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql Chief Executive Officer, President and Chairman of the\plain\intbl\cf1\f51\fs20\ql Board\cell{
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{\trowd\cellx5220\cellx5688\cellx10800\trrh248
\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql (Principal Executive Officer)\cell{
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{\trowd\cellx5220\cellx5688\cellx10800\trrh248
\pard\plain\intbl\cf1\f51\fs20\ql Date: May 15, 2019\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell{
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{\trowd\cellx5220\cellx5688\clbrdrb\brdrs\brdrcf1\cellx10800\trrh248
\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql By:\cell\pard\plain\intbl\cf1\f51\fs20\ql /s/\~DOUGLAS E. ONSI\cell{
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{\trowd\cellx5220\cellx5688\cellx10800\trrh248
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell{
{\trowd\cellx5220\cellx5688\cellx10800\trrh248\row}}}
{\trowd\cellx5220\cellx5688\cellx10800\trrh248
\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql Douglas E. Onsi\cell{
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{\trowd\cellx5220\cellx5688\cellx10800\trrh495
\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql Chief Financial Officer, General Counsel, Treasurer and\plain\intbl\cf1\f51\fs20\ql Secretary\cell{
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{\trowd\cellx5220\cellx5688\cellx10800\trrh248
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell{
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\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql (Principal Financial Officer and Principal Accounting\plain\intbl\cf1\f51\fs20\ql Officer)\cell{
{\trowd\cellx5220\cellx5688\cellx10800\trrh495\row}}}\pard\plain\cf1\f51\fs20\qc \~\par\pard\plain\fi484\cf1\f51\fs20\i\ql A signed original of this written statement required by Section\~906 has been provided to the Company and will be retained\plain\cf1\f51\fs20\i\ql by the Company and furnished to the Securities and Exchange Commission or its staff upon request.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par}