Determining Responsiveness to Anti-inflammatory Therapy

It has been shown that FeNO predicts the likelihood of steroid responsiveness more consistently than spirometry, bronchodilator response, peak flow variation, or airway hyperresponsiveness to methacholine.2-4

Overview of Clinical Guideline to Interpretation of FeNO Levels1

For the management of patients with suspected or diagnosed asthma

FeNO-GUIDED THERAPY
GOAL RANGE

FeNO levels and inflammation

FeNO (ppb)*

LOW

INTERMEDIATE

HIGH

Adults

<25

25-50

>50

Children (<12 years)

<20

20-35

>35

Th2-driven inflammation

Unlikely

Likely

Significant

Diagnosis Considerations

Interpretation with respect to
steroid response

Unlikely to respond to corticosteroids

May respond to corticosteroids (interpret cautiously in clinical context)

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