Well, I am still having a lot of problems with Launcher no picking up Application, even after the update to 6.5. Typing command-space config and Apple configurator is not in the list. Not just not at the top, but nowhere on the list. Same search with spotlight and it's right there in /Applications/

I'm having the same problem. I also remember having options for what would trigger an index update (either time-based or when folder contents change), but I can't find this anymore. For example, when I install a new application, I have to manually refresh the index for the new app to show up in LaunchBar.