There is increasing evidence that low-
molecular-weight iron dextran (INFeD) is associated with an incidence of reactions that is similar
to that with the newer products but allows for
higher doses of iron replacement — up to 1000
mg — in a single session. But still needs a test dose.

Ferumoxytol (Feraheme) is a superparamagnetic iron oxide coated
with carbohydrate that is marketed as both an
iron-replacement agent and a magnetic resonance
imaging (MRI) contrast agent. One unique complication is severe hypotension,which was observed
in 1.9% of patients in post marketing studies.