Bow Mrs Wavy Pointed Toe High Heels for the Bride at the wedding with Mrs new last married name or Mrs last name on one shoe and the wedding date on the other shoe.

These fabulous custom made heels are light ivory in color & the back heel measures approximately 3 inches.

Your heels are custom hand crafted with our diamond chain beading that traces the elegant lines of satin on this closed toe pump.

The outside sides are customized with your special personalization and lettering color (see chart in listing photos for color selections).

On the sides are cute satin bows with bling centers in your choice of satin ribbon color (see chart in listing photos for color selections)

When ordering this item, please specify in the notes box:

1. Bow color

2. Lettering color

3. Personalization

*If colors are not specified, they will be made in the color of the first listing photo. First listing photo is desert taupe lettering and ivory bows.

Your custom heels will be ready to ship in approx 4-5 weeks. Please allow 2-3 days in shipping time for USA orders.

Questions?

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Bridal Flip Flops business hours are Monday -Friday from 9am-3:30pm and we try to answer all questions in 1 business day or less during those times. Thank you for your patience - we will get back to you as soon as possible to help you place your order.

Abstract

The innate immune system in the lung is essential for controlling infections due to inhaled pathogens. Mycobacterium tuberculosis (M.tb) encounters components of the innate immune system when inhaled into the lung, but the consequences of these interactions are poorly understood. Surfactant protein D (SP-D) binds to and agglutinates M.tb bacilli, and reduces the uptake of the bacteria by human macrophages. In the current studies, we utilized a recombinant SP-D variant (CDM) that lacks the collagen domain to further characterize the interaction of SP-D with M.tb, and determine the effects of agglutination on bacterial uptake by human monocyte-derived macrophages. These studies demonstrate that the binding of SP-D and CDM to M.tb is saturable and inhibited by carbohydrate competition and Ca2+ chelation, implicating the carbohydrate recognition domain in the interaction. Fluorescence microscopy reveals that dodecameric SP-D leads to agglutination of the bacilli, whereas the trimeric CDM does not, demonstrating that the multivalent nature of SP-D is essential for agglutination of M.tb. However, preincubation of M.tb with increasing concentrations of SP-D or CDM leads to a concentration-dependent reduction in the uptake of the bacteria by macrophages, indicating that agglutination does not play a direct role in this observation. Finally, the reduced uptake of M.tb by SP-D is associated with reduced growth of M.tb in monocyte-derived macrophages. These studies provide direct evidence that the inhibition of phagocytosis of M.tb effected by SP-D occurs independently of the aggregation process.