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The analgesic properties of cannabis have been noted for centuries. However, the use of cannabis to treat pain is limited due to its psychoactive properties and abuse liability. Previous studies using models of both acute and persistent pain have demonstrated that locally administered cannabinoid receptor agonists produce peripherally mediated antihyperalgesia. These studies suggest that targeting peripheral cannabinoid receptors may be a useful therapeutic approach to treat pain. We are interested in determining how locally administered cananbinoids affect primary afferent nociceptors.