A recent promising approach for lowering cholesterol is probiotics, living microbial supplements that beneficially affect the host person by improving their gut microbial balance. The most common probiotic bacteria are lactobacilli and bifidobacteria. Probiotic bacteria are generally consumed in the form of fermented dairy products such as yoghurt.

A systematic review of human studies on the effect of vitamin C supplement intake on serum uric acid level, which increases risk of gout, found that vitamin C supplementation was associated with serum uric acid level reduction in 8 out of 13 studies.