not constitute an offer or invitation topurchase securities. ...Morgan Stanley & Co International plc is acting for Shire and ShireLi...THIS ANNOUNCEMENT DOES NOT CONSTITUTE AN INVITATION OR OFFER TO SELL O...Notice To United States Residents ...This announcement is not an offer of securities in the United States....

Morgan Stanley & Co International plc is acting for Shire and Shire
Limited and no one else in connection with the Proposals and will not be
responsible to anyone other than Shire and Shire Limited for the
protections afforded to its clients or for providing advice in relation to
the Proposals or the content of this announcement.

THIS ANNOUNCEMENT DOES NOT CONSTITUTE AN INVITATION OR OFFER TO SELL OR
THE SOLICITATION OF AN INVITATION OR OFFER TO BUY ANY SECURITY. NONE OF THE
SECURITIES REFERRED TO IN THIS ANNOUNCEMENT SHALL BE SOLD, ISSUED,
EXCHANGED OR TRANSFERRED IN ANY JURISDICTION IN CONTRAVENTION OF APPLICABLE
LAWS.

Notice To United States Residents

This announcement is not an offer of securities in the United States.

The Shire Limited ordinary shares to be issued in connection with the
Proposals will not be, and are not required to be, registered with the US
Securities and Exchange Commission under the US Securities Act of 1933, as
amended, in reliance on the exemption from registration provided by Section
3(a)(10) thereof.

The "SAFE HARBOR" Statement Under the Private Securities Litigation
Reform Act of 1995

Statements included herein that are not historical facts are
forward-looking statements. Such forward-looking statements involve a
number of risks and uncertainties and are subject to change at any time. In
the event such risks or uncertainties materialize, Shire's results could be
materially affected. The risks and uncertainties include, but are not
limited to, risks associated with: the inherent uncertainty of
pharmaceutical research; product development including, but not limited to,
the successful development of JUVISTA(R) (Human TGFBeta3) and velaglucerase
alfa (GA-GCB); manufacturing and commercialization including, but not
limited to, the establishment in the market of VYVANSE(TM)(lisdexamfetamine
dimesylate) (Attention Deficit and Hypera'/>"/>

(Date:7/30/2015)... customers across the globe, ISN improves the efficiency and effectiveness of contractor management systems. ... and reliable contractors in over 80 countries. ... ... Over 60,000 Worldwide Customers In More Than 80 Countries ... Headquartered in Dallas, TX , ISN has additional offices in ...

(Date:7/30/2015)... ... July 30, 2015 , ... As part of its 2015 growth plan and as ... technical service business units, Whitehouse Laboratories is pleased to announce that it has ... the Container Center of Excellence and will be strictly dedicated to basic USP 51, USP ...

... 16 MGM Innova, LLC (MGM Innova) and MACTEC ... alliance in carbon management services. Marco G. Monroy, President ... of MACTEC Engineering and Consulting, Inc., made the joint ... become the leading provider of integrated solutions across the ...

... AUSTIN, TexasResearchers at The University of Texas at Austin have ... world,s smallest test tube, measuring a thousandth the diameter of ... small that a high-power electron microscope was required to see ... the test tube was stuffed with a thread-like crystal (a ...

(Date:7/27/2015)... 27, 2015 Zynx Health ™, the ... improvement solutions, today announced that its ZynxCarebook ... on Android smartphones and tablets. With this expansion, ... can use ZynxCarebook to securely exchange messages and ... care transitions to other care settings, and improve ...

... of the University of Granada has found out ... the olive skin wax extracted from alpeorujo (crushed olive pulp), ... apoptosis in carcinogenic processes., Maslinic acid is a protease inhibitor ... growth. It is useful for cancer treatment, as it allows ...

... cigarette after a Valentines Day snuggle can prematurely end a ... in a gene significantly increases a smokers risk of an ... to 70 percent of the population has a gene defect ... recent published study, heavy smokers with this common gene variant ...

... Critically ill patients who need a ventilator to ... infection, however, is exceedingly difficult to diagnose because a ... masks pneumonia,s symptoms a reality that can delay ... at Washington University School of Medicine in St. Louis ...