vigabatrin

Definitions

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n. An anticonvulsant that inhibits the catabolism of GABA by irreversibly inhibiting GABA transaminase.

Etymologies

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Examples

Catalyst is also developing CPP-115, another GABA aminotransferase inhibitor that is more potent than vigabatrin and has reduced side effects e.g., visual field defects, or VFDs from those associated with vigabatrin.

The presentation discussed the medical relevance of GABA aminotransferase inactivators in the treatment of epilepsy and drug addiction, the history of the discovery of CPP-115, a detailed mechanistic analysis of GABA-AT inactivators, and a summary of CPP-115's pharmacological properties, including its superior visual safety profile and potency compared to vigabatrin.

Catalyst has two products in development, and is currently evaluating its lead product and first-in-class GABA aminotransferase inhibitor candidate, CPP-109 vigabatrin, for the treatment of cocaine addiction.

Keppra or levetiracetam, H. Lundbeck's Sabril or vigabatrin, Pfizer's Neurontin or gabapentin and Lyrica or pregabalin, GlaxoSmithKline's Lamictal or lamotrigine, Novartis 'Trileptal or oxcarbazepine and Eisai's Zonegran or zonisamide.

By the end of the third quarter of 2010, most of the safety studies described above, including results from assessments of the comparative retinotoxicity of CPP-115 versus vigabatrin, are expected to be completed.

The increased potency could enable the development of superior or alternative dosage forms and routes of administration compared with the marketed version of vigabatrin, Sabril® (which is marketed in the U.S. by Lundbeck Inc. for infantile spasms and refractory complex partial seizures).