Results

Prone positioning increased IOP a mean±SD of 12±6mmHg.

IOP increased to 38±10mmHg at the end of anesthesia (approximately 5.5h).

Time– weighted average intraoperative IOP in the brimonidine group was 4(95% CI: 1, 8)mmHg lower than in the placebo group (P=0.023), but no different in the crystalloid and albumin groups (mean difference (95% CI) of –2(–5, 2)mmHg (P=0.34).