Description

This track shows genes targeted by
International Knockout Mouse Consortium (IKMC)
mapped to the human genome. IKMC is a
collaboration to generate a public resource of mouse embryonic stem (ES)
cells containing a null mutation in every gene in the mouse genome.
Gene targets are color-coded by status:

Green: Reagent(s) Available

Yellow: In Progress

Blue: Not Started/On Hold

Black: Withdrawn/Problematic

The KnockOut Mouse Project Data
Coordination Center (KOMP DCC) is the central database resource
for coordinating mouse gene targeting within IKMC and provides
web-based query and display tools for IKMC data. In addition, the
KOMP DCC website provides a tool for the scientific community to
nominate genes of interest to be knocked out by the KOMP initiative.

Methods

Using complementary targeting strategies, the IKMC centers
design and create targeting vectors, mutant ES cell lines and, to some
extent, mutant mice, embryos or sperm. Materials are distributed to
the research community.

The KOMP Repository
archives, maintains, and distributes IKMC products. Researchers can
order products and get product information from the
Repository. Researchers can also express interest in products that are
still in the pipeline. They will then receive email notification as
soon as KOMP generated products are available for distribution.