9] Because of its multifactorial pathogenesis and progressive nature, restoration of normoglycemia is difficult to achieve and requires multiple antidiabetic drugs in additive manner with different mechanism of action.

DM1 patients submitted to simultaneous pancreas-kidney transplantation (SPKT) can restore normoglycemia and renal function, which are two concurrent ways to decrease AGE deposition: reducing AGE formation and increasing their renal elimination.

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