The biggest problem is, as RWBlue said, there is little published reloading data. Hodgdon only lists up to 20,000 Cup. Not very helpfull when +P is 23,000 Cup, and I've been told Ace Custom who developed the round is loading at 27,000 Cup. There is no published maximum.

One thing that could help would be a 6 inch after market barrel - that would give slower powders a bit more time to act, which is supposed to help with heavier bullets.

It would be nice to have a reloading thread for 45 Super, similar to the threads on the 10mm Reloading forum.