A scream breaks the silence filling the rest area, jolting Tad, a pharmaceutical rep, out of his nap. After a survey of the rest area, he finds a thirteen-year-old girl named Erin, whose parents have vanished from their RV. With little help from local law enforcement, Tad feels obligated to help the girl. A search leads to their abduction and the discovery of an illegal medical testing facility.

Henry Peters, a Native American widower and chronic pain sufferer does just that when a crooked scientist, Dr. Sterling who is in trouble with a loan shark, tricks him into testing an unapproved drug for chronic pain. During the drug trial he dreams that he's gone back in time and finds his deceased wife living in a native village.