The win snaps a five-game skid for Houston and extends Cleveland's losing streak to five.

Harrell (1-2) allowed two runs in 5 2/3 innings before three relievers combined to shut Cleveland out the rest of the way.

Closer Jose Veras allowed one hit in the ninth for his first save in two tries.

"I was struggling to throw strikes again, it's just kind of been a trend right now," Harrell said. "It's something I need to work on between starts and definitely focus on that. If the defense wouldn't have played so well and if we wouldn't have scored some runs early, it could have been a rough night."

Carlos Pena walked with one out in the second inning before Martinez got Houston's first hit by launching a homer in the stands in right field off former Astro Brett Myers (0-3) to make it 2-0. Martinez left the game with a sprained knee in the fourth inning.

Ankiel followed with another homer to right field to push the lead to 3-0.

Lonnie Chisenhall closed the gap to 3-2 when he connected on a homer that sailed just inside the foul pole in right field in the fourth inning.

Myers, who was facing Houston for the first time since a trade last summer, allowed five hits and three runs with four strikeouts in five innings. He has given up an MLB-high 10 home runs with an 8.02 ERA in four games with three starts this season.

Harrell was chased by a single by Mark Reynolds with two outs in the sixth inning, and was none too happy about it. He stalked off the field before throwing his glove, hat and a cup of water when he reached the dugout.

He yielded five hits and two runs with five walks and four strikeouts.

"I stress this all the time: there are going to be different break points in the game, and when you win those break points you put yourself in the best position to win the ball game," Houston manager Bo Porter said. "And we were able to do that tonight, and those guys continued to make pitches and made quality pitches to get out of those tough jams."

The Indians couldn't string together any hits late in the game as they fell to 0-10 this season when trailing after six innings. Jason Kipnis singled with two outs in the seventh inning before Asdrubal Cabrera struck out swinging to end the inning. The frustration for Cabrera, who is hitting .138, was evident after the strikeout when he angrily threw his bat.

Nick Swisher doubled to start the eighth before Carlos Santana drew a one-out walk. But Reynolds grounded into a double play to end the threat.

The Indians haven't been able to generate much offense this season and have been held to three runs or less in five straight games and 10 of 15 overall.

"We did have opportunities," Indians manager Terry Francona said. "I think what happens sometimes is, guys try too hard. We had a couple of chances, and we rolled over. We had opportunities to win that game because of our pitching."

Martinez left the game in the fourth inning after spraining his right knee while batting. Martinez was injured on a check swing. His knee buckled and he fell to the ground in pain.

He remained on the ground for a couple of minutes while Astros trainers attended to him. He was then helped to his feet and hobbled with assistance back to the dugout. He was replaced by Brandon Barnes and is listed as day to day.

He said after the game that he was "achy and sore" but that he should be OK.

"I was just bummed out more that I couldn't finish the game really," Martinez said. "I was feeling good and I knew it was going to be a good game."

Game notes

The Astros observed a moment of silence before Friday night's game to remember the victims of the Boston Marathon bombings and those killed and injured in the fertilizer plant blast in West, Texas. The Astros are also accepting donations this weekend at the ballpark to send to those affected by the explosion at the fertilizer plant. ... When the jumbotron inside of the park showed television footage from Boston between innings indicating that the second marathon bombing suspect had been taken into custody, fans cheered loudly and some broke into a chant of "USA, USA." ... These teams continue the series on Saturday when Cleveland's Scott Kazmir is expected to come off the disabled list to make his first major league start since April 2011 against Philip Humber. Kazmir, who was on the DL with a rib cage strain, spent last season in the independent Atlantic League with the Sugar Land Skeeters. "The biggest thing is just getting him stretched out again so he can get deep enough into games," Francona said. "He can pitch and he's not going to be scared. So we're excited about it." ... Kipnis was back in the lineup after missing five games with a sore left elbow. ... Cleveland third base coach Brad Mills made his first trip back to Minute Maid Park since being fired as Houston's manager in August. He said it was weird to be back as an opposing coach and that he doesn't have any regrets about his time with the Astros. "(You) try to do the best you can and try to help these guys get better," he said. "I think that was our goal every day and I think that we did that with the guys that were here. Personally you are rooting for the players individually because you spent so much time with them."... Cleveland pitcher Matt Albers was moved from the family medical emergency list to the restricted list on Friday, but Francona said he could be activated on Monday.

Copyright by STATS LLC and The Associated Press

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HOUSTON, TX - APRIL 19: Lucas Harrell #64 of the Houston Astros throws against the Cleveland Indians at Minute...