This is a forbidden technique that is accessible only to those who have mastered the Creation Rebirth technique, and as such, is only usable by Tsunade. While very similar in nature to its parent technique — which facilitates the regeneration of injuries through accelerated cell division — it however does not require the use of hand seals, meaning Tsunade's wounds begin to heal as soon as they are inflicted. Whereas the Creation Rebirth technique needs Tsunade's input to activate, any wound sustained while this technique is in effect will begin recovery automatically. The enhanced regeneration granted by this technique is so advanced and fast, that even impalement by two enormous swords through her abdomen were completely healed in mere moments after the blades' removals .[1]

Use of the technique requires the release of the White Strength Seal, much like Creation Rebirth, but rather than just covering the face, the markings extend over Tsunade's entire body. As a testament to both its power and her confidence in its healing prowess, Tsunade has decreed that only medical-nin who have mastered this technique are permitted to break the first three rules that govern their role on the battlefield — which effectively prohibit their direct involvement in any conflict — that she herself established.[2]

Trivia

When written as '白毫', byakugō means 'Ūrṇā' (Literally meaning: Fine White Hair), which is a white swirl of fine hair on the forehead of the Buddha, represented in art by a spiral or a dot, or even a gem or pearl. It represents the third eye which allows one to see past the mundane world and into the divine world. This is a clear allusion to the diamond mark on Tsunade's forehead.

According to Madara Uchiha, this technique is similar in nature to the medical ninjutsu used by Hashirama Senju, in that it heals the user's injuries without requiring hand seals.[3]