Redemption: Eternal Quest

From the developer:

Redemption: Eternal Quest is a unique and challenging RPG/Sim where you manage a group of adventurers, guiding them through thrilling quests and collecting treasure and relics. The difference with this game is you step into the role of managing these warriors, healing them, schooling them, making key decisions and watching them grow into legendary heroes.

It combines roster/resource management with RPG sensibilities, with a completely random world generated every game and even every turn! Explore Ruins, Dungeons, open treasure chests, fulfill Grand Quests, and engage in combat with a unique card-based system. Use the Prestige from your discoveries to drive your party to even greater heights.

Features an attractive and intuitive UI and orchestral music, over 200 different Minion cards each with different combat strength ranges, thousands of possible events and treasures, and a full aging, morale, hidden potential curve and injury/disease engine, you help to guide this group through many amazing quests, all the while signing your warriors to pacts and negotiating the best deal for them and yourself.

You can choose how you want to play: want permadeath? You got it. Want it so no one ever dies? Want the pacts to go away? You can set it that way too. All of this along with options to set the length of the game any way you like and lots of random generation make this almost endlessly replayable.