Brief description of study

The purpose of this research is to determine if an investigational new drug solution called
Prismocitrate 18 lengthens extracorporeal circuit life in patients treated with continuous
renal replacement therapy (CRRT). Patients who receive CRRT treatment with Prismocitrate 18
as the anticoagulant will be compared to patients who receive CRRT treatment with no
anticoagulation.