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All articles from Creative Biolabs

Creative Biolabs is a phage display company specialized in applying phage display technology to generate various phage display peptide, protein, antibody libraries for drug development and antibody discovery purposes.

Phage display has become a important tool in immunological and cellular biological research owing to its remarkable contribution for the development of new drugs and vaccines. As one of the most successful applications, phage display technology has proved its safety and efficiency in the research and development of specific antibodies....

With the efforts of its scientists and other staff members, Creative Biolabs announced Dual Variable Domain Immunoglobulin (DVD-Ig) Production Service. This service is able to provide immunoglobulin molecules that simultaneously target two mediators of disease with a single pharmaceutical entity.Â

The DVD-Ig is an IgG-like molecule, except that each light chain and heavy chain contains two variable domains in tandem through a short peptide linkage instead of one variable domain. As simultaneous blockade of multiple targets may yield better therapeutic efficacy than inhibition of a single target, they were originally designed for the treatment of complex diseases in which multiple mediators contribute to overall disease pathogenesis by distinct or redundant mechanisms....

As we all know, many cellular activities are controlled by post-translational modifications, the study of which is stuck by the lack of specific reagents due greatly to their nature of ubiquitousness and non-immunogenicity.Â With great efforts, Creative BiolabsÂ has developed PTM-Abâ„˘ technology, which offers services for post-translational modification specific antibody discovery.

Post-translational modifications are modifications that occur on a protein, catalysed by enzymes after its translation by ribosomes is complete. Post-translational modification generally refers to the addition of a functional group covalently to a protein as in phosphorylation and neddylation. Protein post-translational modifications play an important role in many cellular processes, such as cellular differentiation, protein degradation, signaling and regulatory processes, regulation of gene expression, and protein-protein interactions.....

With advanced technology and years of experience in the field of antibody engineering, Creative Biolabs announces a series of custom construction and production services for BiTEs, Bi-specific T-cell engagers.

BiTE antibodies are recombinant fusion proteins consist of two single-chain variable fragments (scFvs) of different antibodies. One is bound to T-cells by CD3 receptor, the other to a tumor cell via a tumor specific molecule. BiTEs create a quite important class of artificial bi-specific monoclonal antibodies for the application of anti-cancer drugs...

Creative BiolabsÂ has developed and commercializes a full range of integrated innovative Bio-fishing services that are based on phage display technology.

With extensive experience in construction of various phage display libraries, including cDNA, peptide and scFv/Fab antibody libraries, Creative Biolabs focuses on developing high specific, high affinity monoclonal antibodies for research, diagnostic and therapeutic use. Creative Biolabs also is professional in screening these libraries against protein, peptide, cells, special surfaces and chemicals.....