Is it OK to set the Logic Level on the USB-BUB-I to 3.3v when uploading to a BBB (optiboot) powered at 5V ?

I have always set the logic level of my USB-BUB at 5v, but accidentally left it at 3.3v prior to uploading today.
The upload went fine.

Would it therefore be OK to permanently connect the Logic Level jumper to 3.3v ?
Then, would I be able to program BBBs or RBBBs running at either 3.3v or 5v, without fussing with the pin header jumper.

Thank you.

BobW2

PS - reason this came up was that I had the jumper set at 5v and connected it to a TP-Link 703n, which runs at 3.3v, and this seems to have killed it. This wouldn't have happened if USB-BUB was hardwired to 3.3v.