Paenibacillus sp. nov. VT 400

Kingdom

Bacteria

Division

Firmicutes

Class

Bacilli

Order

Bacillales

Family

Paenibacillaceae

Genus

Paenibacillus

We have sequenced and analyzed the genome of the previously unculturable clinical strain Paenibacillus sp. strain VT-400, an aerobic, rod-shaped, motile (via peritrichous flagella), endospore-forming, gram-positive bacterium that was isolated from the saliva of a child with acute lymphoblastic leukemia.

Paenibacillus sp. strain VT-400 is a representative of family Paenibacillaceae, which has recently been shown to contain several medically important species associated with urinary tract infections, pneumonia, and bacteremia in humans. The genome of strain VT-400 contains numerous multidrug resistance transporters, including SMR efflux pumps that confer resistance to nosocomial antibiotics, genes encoding resistance to chemotherapeutic drugs used in the treatment of hematological malignancies, etc. The organism also harbors a large number of genes encoding virulence factors such as hemolysin D and CD4+ T cell-stimulating antigen.

Genomic characterization and assessment of the virulence and antibiotic resistance of the novel species Paenibacillus sp. strain VT-400, a potentially pathogenic bacterium in the oral cavity of patients with hematological malignanciesGut pathogens (2016)