Tor Isedal started acting in the 1940s, but his breakthrough came when he met Ingmar Bergman, who gave him a role in the 1960 movie Jungfrukällan (The Virgin Spring), as a brutish mute herdsman. After that, he received many more roles in major TV, film, and theater productions. International co-productions ranged from Pippi in the South Seas (as Pedro) to Victor Frankenstein (as a caretaker).

His voice work included being the first Swedish voice for Winnie the Pooh, Flintheart Glomgold in the first season of Ducktales, and many others.