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A Systematic Approach to the Development of Functional Carbon Nanotube Based Films and Their Applications.

Creator

Tyndall Jr., John (Jack) Lawrene

Abstract/Description

Carbon nanotubes (CNTs) have been demonstrated to possess uniquely valuable electronic properties, good chemical stability, and large surface area. Potential applications include advanced catalytic systems to electrochemical sensors, and highly efficient fuel cells. With an increased interest in flexible/bendable electronics, the need for flexible energy storage devices to work within these devices has grown. Carbon nanotubes have a small diameter, high surface area, and have a graphitic... Show moreCarbon nanotubes (CNTs) have been demonstrated to possess uniquely valuable electronic properties, good chemical stability, and large surface area. Potential applications include advanced catalytic systems to electrochemical sensors, and highly efficient fuel cells. With an increased interest in flexible/bendable electronics, the need for flexible energy storage devices to work within these devices has grown. Carbon nanotubes have a small diameter, high surface area, and have a graphitic structure. Along with their unique properties, it is also their ability to support metal nanoparticles that their application in flexible energy storage applications is actively being studied. The zinc carbon battery was used as a template for these new flexible batteries, with zinc (Zn) working as the anode active material and manganese (IV) oxide (MnO2) serving as the cathode active material. At the center of this research is the addition of CNTs into the battery design. The CNTs high strength and flexibility make them a promising component for thin and flexible batteries and electrodes. The focus of this study is to show how the development of carbon nanotube based materials has rapidly changed in recent years. My work starts with the inclusion of CNTs into tradition assemblies such as the synthesis of functional cross-linked multi-walled carbon nanotube paper films but with nanoparticles incorporated into the cross-linked network. The project then began to focus on the creation of coin cell (button cell) and flexible batteries using the cross-linked carbon nanotube film with manganese (IV) oxide, zinc foil and an electrolytic solution to replicate the electrochemistry of a zinc carbon battery. Cross-linking carbon nanotubes is difficult because of the low degree of surface functionalization which would be used to connect the tubes, so a better way to incorporate the carbon nanotubes into a functional composite was required to move the field of carbon nanotube out of a plateau. The advent of consumer 3D printing with thermoplastics provided a unique opportunity to mix carbon nanotubes with the thermoplastics and eventually photopolymer resins to produce a new class of functional 3D printing materials which are described in this thesis. Show less

Date Issued

2019-12-08

Identifier

FSU_libsubv1_scholarship_submission_1512750938_c8380521

Format

Thesis

Title

Phronesis as Authorial Know-how: A Play on the Art of Living a Well Written Story.

Creator

Carpenter, Jennifer

Abstract/Description

A Letter to the Audience Before I draw the curtain and release the philosophical coddiwomple that follows, I would like to take this time to reflect on its coming to be and, hopefully, explain myself to the audience. A preemptive rundown and a warning (or two) of what this project is meant to be--and why I've chosen to write it in this way--will be helpful in understanding what’s going on. To start, I’d like to ward off any high expectations for traditional order or strict structure to my... Show moreA Letter to the Audience Before I draw the curtain and release the philosophical coddiwomple that follows, I would like to take this time to reflect on its coming to be and, hopefully, explain myself to the audience. A preemptive rundown and a warning (or two) of what this project is meant to be--and why I've chosen to write it in this way--will be helpful in understanding what’s going on. To start, I’d like to ward off any high expectations for traditional order or strict structure to my creative project: I make no claim to the exactness or completeness to the words written here. Of course I suppose my argument could have been made by writing a regular paper, and probably with less words at that, and, to justify this piece of thoughtful whimsy, I’ll start by answering this obvious question that the reader might find themselves asking--why didn't I? It's a fair question. There are so many ways I would like to address this question, but I’ll try to constrain myself to the most topical. First, in the most blunt way: I've get lyrically restless writing philosophy in the prescribed formats and sometimes adhering to strict contextual expectations can restrict the writer on a thoughtful quest. I long for the days when philosophers were allowed a bit of creative freedom in getting their thoughts out there; mostly relying on their own thinking and just writing it in the way they wanted. I feel restrained by rules of philosophical writing, at times, and I think this subject beckons for me to stretch my imagination and ignore (for the moment) the need to follow a certain path of inquiry. This reason, for the unorthodox method that I take, address the less than straightforward way I go about putting forth my case: lives are not straightforward. Nothing about by subject is straightforward. Our lives, conduct and even characters are barely legible to us. Once more, our thoughts are not like he standard philosophical paper--not really. Academic papers (strictly academic) are crafted y stepping outside oneself to edit. Our thoughts do not chug along like a train down one track, at least mine do not. It's more like flying a kite. I have this idea, storytelling as the art of living, and I release it letting the thought mingle with my other beliefs, desires, and goals. The control I have the kite is minimal, just a flimsy piece of plastic and a big of string. Every once in a while a gust of whimsy blows by and takes my kid away, then, I have to slowly gain back control by guiding into a better position. As the reader will experience in the arupt way in which conversations end and begin. It will help to see this piece as the writing process of what would be philosophy paper, refined for presentation. I wanted to represent this attitude in the setting of the lay, thus, I set my scene within the mind of a student reading Aristotle with my interlocutors being character manifestations of our student's different perspectives. Her multitudes, if you will, come together to interpret Aristotle's lesson for living well as a lesson in writing well; with one of them further arguing that his lesson is taught to convince us that is self-authorship is what makes a life well lived. As our student reads the relevant passages from Aristotle, lachessi presents her authorial analogy to the group: showing how authorship is practical wisdom and how this take on wisdom better informs us as to what happy people are doing. After Which the collective discusses Lachesis Second claim, that, Aristotle is telling us to become the author of our own stories. Finding the form that best fit the matter at hand is not an easy task; I struggled to find an appropriate vessel for discussion the art of living as the art of storytelling. I needed a narrative form, that relies on heavy dialogue, and one that would allow for me to incorporate quotes from the nicomachean ethics in a way that wouldn't interrupt the flow. I, also, wanted a writing style that could allow be to sway a bit from the course, in a relevant manner. A stage play is the practical choice for m project mostly because of its dialog aspect; and the organization's of acts and scene help to keep the dialogues as individual conversations that go together, yet, do not exactly merge seamlessly from topic to topic. This type allows me to connect Aristotle's Phronimos to the well written author and discuss how she embodies the notion of authoring her one's own life. Show less

Hypoxia has been known to influence drastic changes in an organism at a molecular level. New studies are constantly unveiling new information about how organisms respond to hypoxic condition, but the mechanism in which these organisms do so is complex and remains undetermined. In this study, a full transcriptome analysis of maize (Zea mays) apical meristem tissue was conducted under hypoxic conditions by utilizing RNA-seq. The transcriptomic data received from various time points over the... Show moreHypoxia has been known to influence drastic changes in an organism at a molecular level. New studies are constantly unveiling new information about how organisms respond to hypoxic condition, but the mechanism in which these organisms do so is complex and remains undetermined. In this study, a full transcriptome analysis of maize (Zea mays) apical meristem tissue was conducted under hypoxic conditions by utilizing RNA-seq. The transcriptomic data received from various time points over the duration of 18 hours of hypoxia provided valuable information about the transcriptional response of hypoxic responsive genes over time. These data prompted a deeper probe into the short-term response at the 2 hour mark. An additional RNA-seq protocol was carried out after 2 hours of flood-induced hypoxia. Intensified expression levels were found in the known hypoxic responsive genes pyruvate decarboxylase (PDC) and alcohol dehydrogenase (ADH). Induced transcription was observed in the rice (Oryza sativa japonica) ortholog (Zm00001d023859), which is known for ethylene-induced aerenchyma formation in roots under oxygen deficient conditions in rice. Moreover the rice ortholog (Zm00001d022084) also displayed up-regulation in gene expression compared to the control. This gene is implicated flooding tolerance during seed germination and early seedling growth in rice but is minimally annotated in maize. Induction was achieved in other hypoxia responsive genes, but not nearly to the same degree. It was thus concluded that 2 hours is an important transition period for the inbred maize line B73 to reach optimal response to hypoxia. It is hoped that this data can be used to unveil the chromatin dynamics behind this hypoxic stress response. Show less

Date Issued

2018-08-07

Identifier

FSU_libsubv1_scholarship_submission_1533651783_b354e488

Format

Thesis

Title

Directed Evolution of the CRISPR AceCas9 Protein to Increase Speed and Efficiency of Genome Editing.

Creator

Roth, Mitchell O.

Abstract/Description

The CRISPR (Clustered Regularly Interspaced Short Palindromic Repeat) Cas9 protein has been universally applied in the fields of biomedicine, agriculture, and molecular biology as a tool for editing genomes. Currently, the industry of genome engineering is in dire need of a fast, efficient, and highly specific Cas9 protein to use in larger genomes and to prevent off-targeting activity within cells. Here, I will discuss our effort to design novel variants of a thermophilic CRISPR protein... Show moreThe CRISPR (Clustered Regularly Interspaced Short Palindromic Repeat) Cas9 protein has been universally applied in the fields of biomedicine, agriculture, and molecular biology as a tool for editing genomes. Currently, the industry of genome engineering is in dire need of a fast, efficient, and highly specific Cas9 protein to use in larger genomes and to prevent off-targeting activity within cells. Here, I will discuss our effort to design novel variants of a thermophilic CRISPR protein called, "AceCas9." We utilized methods of directed evolution to introduce modifications in the wildtype AceCas9 protein's structure. We tested these variants and the wildtype protein in experiments to better understand and search for 1) An efficient AceCas9 and 2) A specific AceCas9. Show less

Kaposi sarcoma is a type of lymphatic and skin cancer that is caused by Kaposi Sarcoma-associated virus (KSHV). KSHV ORF45 is classified as an immediate early gene that has multifunctional roles. One of its major functions is to activate the extracellular signal-regulated kinase (ERK) and p90 ribosomal kinase 1 and 2 (RSK1/2) in the mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) pathway. It has been discovered that KSHV ORF45 can activate both the ERK and... Show moreKaposi sarcoma is a type of lymphatic and skin cancer that is caused by Kaposi Sarcoma-associated virus (KSHV). KSHV ORF45 is classified as an immediate early gene that has multifunctional roles. One of its major functions is to activate the extracellular signal-regulated kinase (ERK) and p90 ribosomal kinase 1 and 2 (RSK1/2) in the mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) pathway. It has been discovered that KSHV ORF45 can activate both the ERK and RSK which promote the reactivation of KSHV. There is limited evidence that observes the behavior of all KSHV ORF45 homologs. Therefore, we are interested in studying the functional conservativeness within gammaherpesvirus ORF45 subfamily, including the ability of ORF45 homologues to activate ERK and RSK, and the colonigenesis of HeLa cells transfected with ORF45 homologues. In this study, we found that amongst all ORF45 homologues, there is strong conservation in the amino-terminus, ERK, RSK and ORF33 binding sites. We examined that there are different levels of phosphorylated RSK and ERK amongst the gammaherpesvirus homologues. In addition, we examined that G418 selection of different ORF45 homologues. The result showed no significant difference between the gammaherpesvirus-2 subgroups (Rhadinovirus, Macavirus, and Percavirus). Show less

Date Issued

2018-08-03

Identifier

FSU_libsubv1_scholarship_submission_1533768242_bc8f99d4

Format

Thesis

Title

Kinetic Analysis of AceCas9.

Creator

Duboy, Emily C

Abstract/Description

The Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) and CRISPR-associated (CRISPR-Cas) systems utilize Cas proteins and CRISPR RNA (crRNA) to cleave target DNA. The crRNA are responsible for guiding the Cas enzyme to the target DNA sequences whereas the Cas enzyme cleaves the target. Cas9 is one of the most intensively studied CRISPR-Cas systems owing to its potentials for genome editing and clinical applications. To be cleaved by Cas9, the target substrate must have an... Show moreThe Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) and CRISPR-associated (CRISPR-Cas) systems utilize Cas proteins and CRISPR RNA (crRNA) to cleave target DNA. The crRNA are responsible for guiding the Cas enzyme to the target DNA sequences whereas the Cas enzyme cleaves the target. Cas9 is one of the most intensively studied CRISPR-Cas systems owing to its potentials for genome editing and clinical applications. To be cleaved by Cas9, the target substrate must have an about 20-nucleotide long protospacer region which is complementary to the guide region of the crRNA, and a protospacer adjacent motif (PAM) that is recognized and bound by the PAM-interacting domain (PID) of Cas9. Opposed to the most commonly characterized Streptococcus pyogenes Cas9 protein, which optimally utilizes a 20-nt long sgRNA, AceCas9, from organism Acidothermus cellulolycticus, reaches most optimal cleavage activity utilizing a 24-nt long sgRNA, at 50°C. Further various assays reveal that the PID within AceCas9 is possibly involved in substrate specificity and off-target cleavage. Based off in vivo survival assays, we hypothesized that, in addition to PAM recognition and binding, the PID is also involved in AceCas9 substrate specificity. After kinetic studies, varying cleavage rates of AceCas9 PID variants supports that the PID is somewhat responsible for off-target activity, but to what extent is still not understood. The continued characterization of various types of Cas9s will lead to a broadened selection of Cas9s while also improving the proteins application within biomedical research with a greater understanding of Cas9 specificity. Show less

Date Issued

2018-08-03

Identifier

FSU_libsubv1_scholarship_submission_1533314598_f4f3c168

Format

Thesis

Title

Student Reasoning of Conservation of Mechanical Energy in a Gravitational Field Without Other Work-Producing Forces.

Creator

Smith, Cody R

Abstract/Description

This thesis aimed to provide insight into the process students go through in their effort to understand conservation of mechanical energy in an undergraduate studio physics classroom. The data collected includes a transcript of the conversations a group had while working through a lab that asked students to plot potential and kinetic energies versus time of a bouncing kick ball over the course of 3 bounces, the lab reports of 3 groups from said lab, and all of those group members' Force... Show moreThis thesis aimed to provide insight into the process students go through in their effort to understand conservation of mechanical energy in an undergraduate studio physics classroom. The data collected includes a transcript of the conversations a group had while working through a lab that asked students to plot potential and kinetic energies versus time of a bouncing kick ball over the course of 3 bounces, the lab reports of 3 groups from said lab, and all of those group members' Force Concept Inventory and Energy and Momentum Concept Survey pre- and post-tests. The transcript proved most useful in pointing out common starting points in student reasoning, showing what ideas students begin a lab with before they make sense of it all by the end. The most confounding issues that students seemed to have came when a second dimension of motion was added to scenarios (i.e. thinking about a ball rolling down a ramp instead of just bouncing straight up and down). Unfortunately there was not enough evidence for me to make claim about why this second dimension is more of a problem for students, only that this remained an issue for them from the beginning to the end of the semester. Show less

Date Issued

2018-08-02

Identifier

FSU_libsubv1_scholarship_submission_1533244807_a4691678

Format

Thesis

Title

Weighing the Effects of News Bias on Perception and Ideologies.

Creator

McWey, Emily

Abstract/Description

For many Americans in the modern digital age, the media is our primary source of information on current events and politics. Whether it be social media, television, online publications, newspapers, radio, or other forms of mass media, these platforms offer much of the information we absorb about the world around us. By guaranteeing freedom of the press, the First Amendment provides protections for the media and affords these platforms extensive freedoms regarding the news they publish by... Show moreFor many Americans in the modern digital age, the media is our primary source of information on current events and politics. Whether it be social media, television, online publications, newspapers, radio, or other forms of mass media, these platforms offer much of the information we absorb about the world around us. By guaranteeing freedom of the press, the First Amendment provides protections for the media and affords these platforms extensive freedoms regarding the news they publish by guaranteeing freedom of the press. Hence, these platforms have no formal obligation to produce ‘unbiased’ content or discourse which simply states the facts without distorting the truth, using emotionally-charged language, or presenting information in a way that promotes or diminishes relevant ideologies. For the sake of this project, I will solely explore media bias as it arises in ‘the news’, which I am defining here as any written, visual, or verbal broadcasts which convey information to their audiences about current events in regional, national, or international affairs. Generally, news networks aim to inform to their audiences, though the objectivity of such information is not always a factor. Show less

Date Issued

2018-08-02

Identifier

FSU_libsubv1_scholarship_submission_1533699679_f57e26f0

Format

Thesis

Title

Get Out The Vote: Assessing Efforts Aimed At Engaging Non-Habitual Youth Voters.

Creator

Edwards, Karis Layna

Abstract/Description

The goal of this thesis is to understand how we can promote mobilization among youth voters by understanding the link between how these conversations mobilize voters and how we can apply them to an easier means of engagement. We will explore social media as an effective way of reaching out to young voters and encouraging them to turnout on election day. Conversations and messages applied through these platforms will serve to engage the potential voter in a way that mimics that of a real, in... Show moreThe goal of this thesis is to understand how we can promote mobilization among youth voters by understanding the link between how these conversations mobilize voters and how we can apply them to an easier means of engagement. We will explore social media as an effective way of reaching out to young voters and encouraging them to turnout on election day. Conversations and messages applied through these platforms will serve to engage the potential voter in a way that mimics that of a real, in-person conversation. (7) Show less

Date Issued

2018-07-25

Identifier

FSU_libsubv1_scholarship_submission_1533670597_2299a12e

Format

Thesis

Title

A Health Assessment of Historical Human Skeletal Remains from St. Augustine, Florida.

Creator

Berger, Parker L.

Abstract/Description

In recent decades, bioarchaeological technology and methodology used to analyze human skeletal remains and build biological profiles have drastically improved. Florida State University houses human skeletal remains from four sites in St. Augustine, Florida (8SA36-7, 8SA7-6, B28L1and B42L1) which were originally excavated and analyzed in the 1970s. This study uses current techniques to revisit previously examined skeletal material. Estimations of sex, age at death, and stature were reassessed,... Show moreIn recent decades, bioarchaeological technology and methodology used to analyze human skeletal remains and build biological profiles have drastically improved. Florida State University houses human skeletal remains from four sites in St. Augustine, Florida (8SA36-7, 8SA7-6, B28L1and B42L1) which were originally excavated and analyzed in the 1970s. This study uses current techniques to revisit previously examined skeletal material. Estimations of sex, age at death, and stature were reassessed, and new body mass estimations were added. The current labeling of the material from three of the sites differed drastically from the labeling described in the previous analyses. This issue created challenges when trying to compare current finding to those of the previous assessments. However, this analysis yielded significantly different results from previous assessments when assigning sex, while concluding average age and stature estimates similar to previous assessments. Additionally, an updated and shareable digital catalogue, an inventory of materials, and collection of field notes and previous research reports were created. This project adds to established data and serves as a method of conservation of information associated with four St. Augustine archaeological sites. Show less

Date Issued

2018-07-18

Identifier

FSU_libsubv1_scholarship_submission_1531941780_62896e46

Format

Thesis

Title

Health Service Utilization Among Emergent LGB Adults at a Major Southern University.

Creator

Kyre, Kory

Abstract/Description

Studies have shown that LGBTQ+ (lesbian, gay, bisexual, transgender, and queer) individuals experience disparities in health care compared to their straight counterparts. The purpose of this research is to examine the prevalence of barriers to campus health care services encountered by young LGBTQ+ students at a major southern university. Another goal was to provide guidance for health care services in making these spaces more accessible to this vulnerable population. Our sample consisted of... Show moreStudies have shown that LGBTQ+ (lesbian, gay, bisexual, transgender, and queer) individuals experience disparities in health care compared to their straight counterparts. The purpose of this research is to examine the prevalence of barriers to campus health care services encountered by young LGBTQ+ students at a major southern university. Another goal was to provide guidance for health care services in making these spaces more accessible to this vulnerable population. Our sample consisted of 56 LGBTQ+ college-aged participants. While students were generally utilizing the healthcare services provided to them on campus (74% reported using campus services), many faced concerns about disclosure of sexual or gender identity to health care providers and expressed discomfort utilizing services in general. Going forward, we suggest that university health care services provide clearer gender and sexual identity markers in their communications and medical documents to provide a more inclusive and stress-free environment. We also suggest policy changes such as changing the name of the Women’s Clinic to be more inclusive and providing more outreach to the LGBTQ+ student community. Keywords: LGBTQ+, health care utilization, disparities, college students Show less

Date Issued

2018-06-26

Identifier

FSU_libsubv1_scholarship_submission_1531503601_88ce5251

Format

Thesis

Title

An Analysis of the Works Progress Administration in Florida.

Creator

Pierce, Nicholas

Date Issued

2018-05-26

Identifier

FSU_libsubv1_scholarship_submission_1524781345_35edd3cf

Format

Thesis

Title

Three Cents: Reinterpreting The Threepenny Opera as an Immersive Experience.

Creator

Trinci, Anna Jane

Abstract/Description

This Honors Thesis chronicles the process of devising, rehearsing, and executing an immersive theater experience based on Bertolt Brecht, Kurt Weill, and Elisabeth Hauptman's The Threepenny Opera and Guy Debord’s The Society of the Spectacle.

Date Issued

2018-05-06

Identifier

FSU_libsubv1_scholarship_submission_1525637056_e9e39a0f

Format

Thesis

Title

The Malaysian Model of Islamic Governance and Religious Freedom.

Creator

Jones, Zachary Samuel

Date Issued

2018-05-04

Identifier

FSU_libsubv1_scholarship_submission_1525449380_a3cd7781

Format

Thesis

Title

Photographs.

Creator

Alsina, Lauren

Date Issued

2018-05-04

Identifier

FSU_libsubv1_scholarship_submission_1525451645_f6523834

Format

Thesis

Title

How Restricting Cell Phones May Paradoxically Restrict a Student's Performance.

Creator

Dubon, Dominique

Abstract/Description

Organizations today searching for new ways to develop a more prolific work environment often take into consideration both employee productivity and well-being. Research on work-life balance suggests that separating work from other daily activities can be beneficial for both productivity and well-being, but modern technological innovations have blurred this line between a work and social life. The shift to a 24/7 work environment has led to various studies searching for ways technology is... Show moreOrganizations today searching for new ways to develop a more prolific work environment often take into consideration both employee productivity and well-being. Research on work-life balance suggests that separating work from other daily activities can be beneficial for both productivity and well-being, but modern technological innovations have blurred this line between a work and social life. The shift to a 24/7 work environment has led to various studies searching for ways technology is affecting psychological health and the work environment itself. Past research suggests that cell phones impair academic performance, but effectively managing cell phone use may provide a channel for a better work-life fusion. Based on previous research, I predict that restricting the use of cell phones in classrooms may negatively affect academic performance. Additionally, this restriction may affect current mood, specifically increasing negative affect, with also increased levels of anxiety. If so, this would suggest that administrators may need to adjust their management of technology strategies in the classroom and subsequently the workplace. Show less

Our aim was to assess how much time individuals would be willing to spend playing brain games to gain prolonged functional independence. In Experiment 1, data from 337 adults (ages 20-73) were collected. Participants completed a survey asking them how much time they would be willing to invest in daily brain training to extend their functional independence by certain amounts of time (e.g., 1 month, 1 year). Participants also completed surveys assessing self-perceived health and cognitive... Show moreOur aim was to assess how much time individuals would be willing to spend playing brain games to gain prolonged functional independence. In Experiment 1, data from 337 adults (ages 20-73) were collected. Participants completed a survey asking them how much time they would be willing to invest in daily brain training to extend their functional independence by certain amounts of time (e.g., 1 month, 1 year). Participants also completed surveys assessing self-perceived health and cognitive functioning, personality, technology experience, and demographic variables. Even for relatively small gains (extending functional independence 1 week), participants reported being willing to dedicate an average of 11.5 minutes (SD = 19) every day to brain training, with some participants reporting being willing to play for significantly longer. The best predictor of willingness to invest time into brain training was belief in brain training efficacy, β = .36, t(330) = 7.75, p < .001. There was also a positive association between self-perceptions of cognitive deficits and willingness to engage in brain training, β = .10, t(330) = 2.00, p < .05. Experiment 2 was much smaller (N = 29, all older adults), and thus could not effectively explore individual differences. However, it was found that participants were willing to invest a large amount of time for relatively small gains. Results indicate that individuals are willing to invest a significant amount of time each day playing brain games to remain in their own homes and be independent longer. However, intention to engage in daily brain training was influenced by the perceived amount of benefit and self-perceived cognitive deficits. This has implications for predicting the adoption of, and adherence to, potentially effective treatments for cognitive decline. Show less

Date Issued

2018-05-03

Identifier

FSU_libsubv1_scholarship_submission_1525379156_c497aef6

Format

Thesis

Title

The Relationship Between Sugar Intake and Neural Marker of Anxiety In Young Children.

Despite near scientific consensus that Earth is warming, much of the general public remains unwilling to acknowledge the reality of climate change. This striking mismatch suggests that the scientific community could improve the clarity and persuasiveness of its message. The current work draws upon two psychological theories in an attempt to increase the success of proenvironmental appeals regarding climate change. Moral foundations theory suggests that liberals respond best to messages framed... Show moreDespite near scientific consensus that Earth is warming, much of the general public remains unwilling to acknowledge the reality of climate change. This striking mismatch suggests that the scientific community could improve the clarity and persuasiveness of its message. The current work draws upon two psychological theories in an attempt to increase the success of proenvironmental appeals regarding climate change. Moral foundations theory suggests that liberals respond best to messages framed in terms of harm and fairness, whereas conservatives respond best to messages framed in terms of ingroup loyalty, respect for authority, and purity. Meanwhile, construal level theory suggests that people may find arguments more persuasive when they are relayed in specific, concrete terms rather than general, abstract terms. We combined these theories by presenting liberal and conservative participants with climate change messages framed in abstract or concrete terms, and based in either harm and fairness or ingroup loyalty, respect for authority, and purity. We then assessed relevant proenvironmental intentions and beliefs. Overall, liberals scored higher than conservatives on these attitudes, and this measure was positively correlated with moral concerns about harm and fairness and negatively correlated with moral concerns about purity. However, the manipulations did not significantly impact our results. Together, these findings suggest that framing messages through this technique may not systematically influence proenvironmental attitudes. Show less

Date Issued

05/01/2018

Identifier

FSU_libsubv1_scholarship_submission_1525187748_31661c8b

Format

Thesis

Title

Metrics For The Evaluation Of The Southern Ocean In Coupled Climate Models And Earth System Models.

The Southern Ocean is central to the global climate and the global carbon cycle, and to the climate's response to increasing levels of atmospheric greenhouse gases, as it ventilates a large fraction of the global ocean volume. Global coupled climate models and earth system models, however, vary widely in their simulations of the Southern Ocean and its role in, and response to, the ongoing anthropogenic trend. Due to the region's complex water-mass structure and dynamics, Southern Ocean carbon... Show moreThe Southern Ocean is central to the global climate and the global carbon cycle, and to the climate's response to increasing levels of atmospheric greenhouse gases, as it ventilates a large fraction of the global ocean volume. Global coupled climate models and earth system models, however, vary widely in their simulations of the Southern Ocean and its role in, and response to, the ongoing anthropogenic trend. Due to the region's complex water-mass structure and dynamics, Southern Ocean carbon and heat uptake depend on a combination of winds, eddies, mixing, buoyancy fluxes, and topography. Observationally based metrics are critical for discerning processes and mechanisms, and for validating and comparing climate and earth system models. New observations and understanding have allowed for progress in the creation of observationally based data/model metrics for the Southern Ocean. Metrics presented here provide a means to assess multiple simulations relative to the best available observations and observational products. Climate models that perform better according to these metrics also better simulate the uptake of heat and carbon by the Southern Ocean. This report is not strictly an intercomparison, but rather a distillation of key metrics that can reliably quantify the "accuracy" of a simulation against observed, or at least observable, quantities. One overall goal is to recommend standardization of observationally based benchmarks that the modeling community should aspire to meet in order to reduce uncertainties in climate projections, and especially uncertainties related to oceanic heat and carbon uptake. Plain Language Summary Observationally based metrics are essential for the standardized evaluation of climate and earth system models, and for reducing the uncertainty associated with future projections by those models. Show less

Date Issued

2018-05-01

Identifier

FSU_libsubv1_wos_000436111400001, 10.1002/2017JC013461

Format

Thesis

Title

Metabolic and Mitotic Roles for the Kinesin-4 KLP3A.

Creator

Huetteman, Kaitlyn

Abstract/Description

The centrosome is the main microtubule-organizing center in animal cells. Centrosomin (Cnn), a gene that encodes a centrosomal protein, is key to centrosome function. Mutations in the human Cnn gene are associated with an inherited developmental syndrome called autosomal recessive primary microcephaly (MCPH). Cnn mutant Drosophila were used as a model in order to examine the genetic basis of the disorder. Through preliminary screening of the mutant, we discovered that genes regulating... Show moreThe centrosome is the main microtubule-organizing center in animal cells. Centrosomin (Cnn), a gene that encodes a centrosomal protein, is key to centrosome function. Mutations in the human Cnn gene are associated with an inherited developmental syndrome called autosomal recessive primary microcephaly (MCPH). Cnn mutant Drosophila were used as a model in order to examine the genetic basis of the disorder. Through preliminary screening of the mutant, we discovered that genes regulating metabolism augmented the affects of Cnn, making these mutants susceptible to starvation sensitivity. Additionally, a forward genetic screen revealed mutations that were synthetic lethal with Cnn and we subsequently tested them for starvation sensitivity. Our goal was to identify which other genes regulate metabolism in the Cnn genetic network. One mutation that fulfilled criteria for starvation sensitivity was mapped to a gene that encodes a microtubule-based motor protein involved in transportation and spindle formation. Likely, this candidate shares a microtubule-based function with Cnn. My project investigated whether these mutants are defective in the regulation of metabolism and microtubule assembly in mitosis, and will contribute to our understanding the genetics of the disease pathway of MCPH. Show less

This thesis, as part of the international research consortium “ManyBabies”, aims to identify differences in the effect sizes of infant speech preferences based on data cleaning practices and the potential confounding variables of gender, trial order, and participant age. These questions are of interest specifically in the context of study replication, particularly if these factors could explain some of the issues there are with replicating developmental psychology studies. It was thought that... Show moreThis thesis, as part of the international research consortium “ManyBabies”, aims to identify differences in the effect sizes of infant speech preferences based on data cleaning practices and the potential confounding variables of gender, trial order, and participant age. These questions are of interest specifically in the context of study replication, particularly if these factors could explain some of the issues there are with replicating developmental psychology studies. It was thought that infant-directed speech (IDS) clips would have significantly longer screen looking times than adult-directed speech (ADS) clips, and that these effects would be significantly impacted by trial number and the participant age, but less so by gender. The experiment was conducted using an eyetracking paradigm where IDS and ADS audio clips were presented in one of four trial orders. Results found that there was a significant effect of trial type on mean looking time (p < .001) with IDS trials looked at longer than ADS trials. The variables of gender and trial order also had significant effects on looking time across all four conditions. Participant age did not have a significant effect on looking time until participants younger than 365 days were compared with those older than 365 days, where it was found older participants had significantly longer looking time for adult-directed speech trials than younger participants. These findings can be used to formulate better practices for study replication to ensure that potential confounding variables are accounted for; common data cleaning practices were also not found to have a significant influence on effect significance. Show less

Solid polymer electrolytes have the potential to produce safe, effective alternative to liquid batteries. Creative, new approaches must be developed to determine reaction kinetics. An alternative method to cyclic voltammetry in rotating disk electrodes has been developed in solid polymer electrolytes. The novel pulsed voltammetry approach analysis was verified using a rotating disk electrode with a liquid ferri/ferrocyanide redox couple, and reasonable agreement for exchange current density... Show moreSolid polymer electrolytes have the potential to produce safe, effective alternative to liquid batteries. Creative, new approaches must be developed to determine reaction kinetics. An alternative method to cyclic voltammetry in rotating disk electrodes has been developed in solid polymer electrolytes. The novel pulsed voltammetry approach analysis was verified using a rotating disk electrode with a liquid ferri/ferrocyanide redox couple, and reasonable agreement for exchange current density was found. Reaction kinetics of lithium electrodes were also studied in solid polymer electrolytes consisting of lithium bis(trifluoromethanesulfonyl)imide salt (LiTFSI) dissolved in polystyrene-b-poly(ethylene oxide) block copolymers (SEO). Symmetric Li cells were cycled with pulsed voltammetry to measure current at different salt concentrations and temperatures. Butler-Volmer kinetics for single-electron transfer, reversible reactions were applied to obtain exchange current density and the transfer coefficients. The plating reaction rate of lithium metal was found to be significantly greater than the stripping reaction rate. Reaction kinetics were found to be nearly independent of salt concentration, which suggests that they are dominated primarily by the nature of the lithium metal surface. The activation energy and pre-exponential factor for the plating of lithium metal was found to be a weak function of salt concentration. Show less

Date Issued

2018-04-27

Identifier

FSU_libsubv1_scholarship_submission_1524850184_6a0b8089

Format

Thesis

Title

Parasubicular Neurons in Temporal Lobe Epilepsy.

Creator

Don, Hershel, Sullenberger, Thomas, Kumar, Sanjay S

Abstract/Description

We used histopathological techniques and confocal laser microscopy to assay and quantify neuronal density in the parasubiculum and Medial Entorhinal Area (L3) in control and epileptic rats. Cell loss in L3 of the Medial Entorhinal Area is known and well-documented in both human patients and rat models of Temporal Lobe Epilepsy, however the smaller, adjacent parasubiculum is less studied in this respect. Using an indigenously developed cell quantification method, we determined significant loss... Show moreWe used histopathological techniques and confocal laser microscopy to assay and quantify neuronal density in the parasubiculum and Medial Entorhinal Area (L3) in control and epileptic rats. Cell loss in L3 of the Medial Entorhinal Area is known and well-documented in both human patients and rat models of Temporal Lobe Epilepsy, however the smaller, adjacent parasubiculum is less studied in this respect. Using an indigenously developed cell quantification method, we determined significant loss of neurons in the parasubiculum, using the previously-observed cell loss in L3 of the Medial Entorhinal Area as control. Show less

Date Issued

2018-04-27

Identifier

FSU_libsubv1_scholarship_submission_1524852017_f696b4c8

Format

Thesis

Title

Corregidora's Blues: Re-Inventing the Mulatto Identity.

Creator

McGrew, Darius O.

Abstract/Description

Corregidora posits Blues as a conduit through which Ursa may address the transgenerational trauma which has plagued the matriarchy of her biracial genealogy. This trauma underscores the importance of memory and oral tradition in African-American culture, and demonstrates the personal and political agency by which it may be characterized. Blues functions as an agent of self-determination and a subsequent contradiction to the tragic mulatto trope, my written Thesis will analyze and draw... Show moreCorregidora posits Blues as a conduit through which Ursa may address the transgenerational trauma which has plagued the matriarchy of her biracial genealogy. This trauma underscores the importance of memory and oral tradition in African-American culture, and demonstrates the personal and political agency by which it may be characterized. Blues functions as an agent of self-determination and a subsequent contradiction to the tragic mulatto trope, my written Thesis will analyze and draw connections between Corregidora and “Was Your Mama a Mulatto?”. My goal is to wholly identify the role of Blues in the alternate presentation of the tragic mulatto figure in Corregidora. Show less

Date Issued

04/27/2018

Identifier

FSU_libsubv1_scholarship_submission_1524860905_b0ea2cd8

Format

Thesis

Title

From My Grandfather's Hands: El Coqui: A Puerto Rican Play.

Creator

Mercado, Cristian A

Date Issued

2018-04-27

Identifier

FSU_libsubv1_scholarship_submission_1524859097_38969e99

Format

Thesis

Title

Effects of Effort and Ability Feedback on Emotions Toward Math.

Creator

Shorter, Courtney N

Abstract/Description

Emotions toward academic subjects can positively or negatively affect achievement, but little work focuses on state emotions, which occur during math tasks. This preregistered study addresses the lack of research on state emotions by measuring students’ self-reported emotions while taking varied math quizzes and receiving three possible types of feedback. The 147 college students took math quizzes that involved either success or failure, and were asked about their current feelings of pride,... Show moreEmotions toward academic subjects can positively or negatively affect achievement, but little work focuses on state emotions, which occur during math tasks. This preregistered study addresses the lack of research on state emotions by measuring students’ self-reported emotions while taking varied math quizzes and receiving three possible types of feedback. The 147 college students took math quizzes that involved either success or failure, and were asked about their current feelings of pride, enjoyment, anxiety, boredom, and anger. Students were also randomly assigned to effort, ability, or no feedback conditions. Using repeated measures analyses of variance, we found that students had more positive and less negative emotions after experiencing success compared to experiencing failure. The only effect of type of feedback was on anger, which showed that there was a significant increase in anger reports for the effort feedback condition between the time before conditions started and after. Additionally, type of feedback had no significant effect on math performance. The correlations between growth and fixed mindsets and emotions in response to success and failure showed only a small positive correlation between growth mindset and enjoyment. There were no significant correlations between growth or fixed mindset and math performance. Therefore, our results suggest that emotions change in responses to success and failure, that feedback had a minimal effect on emotions towards and performance in math, and that mindset is minimally correlated to emotions or performance. Show less

Date Issued

2018-04-27

Identifier

FSU_libsubv1_scholarship_submission_1524859362_57a4d3c3

Format

Thesis

Title

Finishing Sophocles: An Attempt to Recreate a Fragmented Satyr Play.

Creator

Vancini, Charles Benjamin

Abstract/Description

Under the supervision of Dr. Samer Al-Saber, I researched ancient Athenian culture and the satyr play dramatic tradition in order to recreate the lost ending to Sophocles' Ichneutae. This project combined dedicated academic research with playwriting and artistic creativity.

Date Issued

2018-04-27

Identifier

FSU_libsubv1_scholarship_submission_1524843337_38251a22

Format

Thesis

Title

Millennial Financial Preparedness Across Racial Groups.

Creator

Keen, Trissanne Lee Anna

Abstract/Description

This research study surveys 680 Millennials to analyze how financial literacy and financial behaviors vary across different racial groups. Respondents in this study consisted of Asians, Black/African Americans, Hispanics and Caucasians. Results from the study demonstrated that only 59% of survey respondents could answer financial literacy questions correctly. Moreover, Caucasians displayed the highest level of financial literacy compared to other racial groups, and women displayed lower... Show moreThis research study surveys 680 Millennials to analyze how financial literacy and financial behaviors vary across different racial groups. Respondents in this study consisted of Asians, Black/African Americans, Hispanics and Caucasians. Results from the study demonstrated that only 59% of survey respondents could answer financial literacy questions correctly. Moreover, Caucasians displayed the highest level of financial literacy compared to other racial groups, and women displayed lower levels of financial literacy than men. This study concludes that Millennials are not knowledgeable on subjects concerning financial concepts. In essence, Millennials lack of financial knowledge can lead to them making sub-optimal financial decisions which can be detrimental to their success. Show less

Date Issued

2018-04-27

Identifier

FSU_libsubv1_scholarship_submission_1524845287_2acaf164

Format

Thesis

Title

Inotropic Effect of Epigallocatechin-3-Gallate on Arrthymias in Ischemic Mouse Heart.

Creator

Kiss, Kaelin

Date Issued

2018-04-27

Identifier

FSU_libsubv1_scholarship_submission_1524843472_781937dd

Format

Thesis

Title

Investigating SREBP2 as a Potential Zika Virus Host Cofactor.

Creator

Bell, Alexander Bell, Lee, Emily, Tang, Hengli

Abstract/Description

Zika virus (ZIKV) is an Aedes mosquito transmitted flavivirus that has drawn global concern during the 2015-2016 epidemic in the Americas. The identification of host proteins and pathways may elucidate potential drug targets for antiviral therapy. Cholesterol synthesis has been shown to play an important role in the pathogenesis of several members of the flaviviridae family.16,18 Cholesterol biosynthesis occurs via the mevalonate pathway, and all participating enzymes are transcriptionally... Show moreZika virus (ZIKV) is an Aedes mosquito transmitted flavivirus that has drawn global concern during the 2015-2016 epidemic in the Americas. The identification of host proteins and pathways may elucidate potential drug targets for antiviral therapy. Cholesterol synthesis has been shown to play an important role in the pathogenesis of several members of the flaviviridae family.16,18 Cholesterol biosynthesis occurs via the mevalonate pathway, and all participating enzymes are transcriptionally regulated by sterol regulatory-element binding proteins (SREBPs). 12,13 RNAi mediated expression knockdown of SREBP2 followed by NS1 FRET analysis reveals a 43% decrease in ZIKV infectivity in SNB-19 cells. Interestingly, RNAi mediated expression knockdown of individual genes that are transcriptionally activated by SREBP2 results in an increase of ZIKV infectivity. This suggests that the antiviral effect of SREBP2 knockdown is not solely mediated by depletion of mevalonate pathway products such as cholesterol. We hypothesize that the SREBP2 post-translational processing pathway contains pro-viral elements, and that ZIKV infectivity can be modulated by the activity of the pathway. Knockdown of SREBP2 does not induce spontaneous interferon beta (IFN-β) expression, but may increase IFN-β expression in the response to an infection. Overexpression of SREBP2 and SREBP1a result in increased transcription of mevalonate pathway enzymes, and increased ZIKV infection. SREBP1a’s enhancement of ZIKV infectivity indicates that SREBP2’s pro-viral role is likely mediated through the activity of it’s transcriptional targets. The specific mechanism of SREBP2’s interaction with ZIKV is not known, and is the subject of potential future plans for investigation. Show less

Date Issued

2018-04-27

Identifier

FSU_libsubv1_scholarship_submission_1524861754_b7c9463e

Format

Thesis

Title

Relationship between Vocabulary Knowledge and Morphological Awareness in English Learners.

Creator

Baldauf, Nicole Sue

Abstract/Description

This study examined the relationship between vocabulary knowledge and morphological awareness. It was thought that these two measures would be positively correlated. There were 35 participants from a summer migrant education program ranging in age from fourth to seventh grade. There were three measures of morphological awareness and two measures of vocabulary knowledge that were examined for correlation. The results showed that there was in fact a positive correlation between each of the... Show moreThis study examined the relationship between vocabulary knowledge and morphological awareness. It was thought that these two measures would be positively correlated. There were 35 participants from a summer migrant education program ranging in age from fourth to seventh grade. There were three measures of morphological awareness and two measures of vocabulary knowledge that were examined for correlation. The results showed that there was in fact a positive correlation between each of the compared morphological awareness and vocabulary knowledge tasks. These correlations ranged in strength from moderately to strongly correlated. Future research should also focus on the population of English Learners as it is underrepresented however, it should be causal in order to inform clinicians and teachers on the best method in which to aid English Learners. Show less

Date Issued

4/27/2018

Identifier

FSU_libsubv1_scholarship_submission_1524843199_54d787c8

Format

Thesis

Title

The Correlation of Tumor Necrosis Factor-Alpha Production with Body Mass Index in Men and Women.

Creator

Keen, Shanon Deidre

Abstract/Description

The increasing prevalence of obesity is a major public health concern since it is associated with many chronic diseases and imparts a large economic burden in the United States (U.S). Obesity is marked as a state of chronic low grade inflammation that can lead to insulin resistance. The objective of this study was to examine if Tumor Necrosis Factor-Alpha (TNF-α) serum levels were higher in obese individuals or overweight individuals. A cross-sectional study was conducted that included a... Show moreThe increasing prevalence of obesity is a major public health concern since it is associated with many chronic diseases and imparts a large economic burden in the United States (U.S). Obesity is marked as a state of chronic low grade inflammation that can lead to insulin resistance. The objective of this study was to examine if Tumor Necrosis Factor-Alpha (TNF-α) serum levels were higher in obese individuals or overweight individuals. A cross-sectional study was conducted that included a total of 68 men and postmenopausal women between the ages of 45 to 65 years who were overweight (n=26) or obese (n=42). Measurements of each participant’s BMI were done and fasting venous blood was collected to assess TNF-α serum levels. An ELISA kit was used to measure the serum levels of TNF-α. Data were analyzed using Pearson’s Product Moment correlations (r), where the degree of the relationships between BMI and TNF-α serum production was assessed to determine the relationship between variables. Data were presented as mean ± standard deviation (SD). Significance was accepted at p≤0.05. There were no significant difference between the TNF-α serum levels in the group of overweight individuals 0.86 ± 0.25(pg/ml) and the obese group: 0.92 ± 0.42 (pg/ml). Numerically speaking there were 6% differences between overweight verses obese individuals. Our findings, albeit not significantly, support the notion that TNF-α plays a role in the development of insulin resistance due to obesity. Show less

Date Issued

2018-04-27

Identifier

FSU_libsubv1_scholarship_submission_1524843967_ace63889

Format

Thesis

Title

La Sorella Dell'Ave: The Sister of the Ave Maria: A Translation of the Romanzi in Versi by Ludovica Ripa di Meana.

Creator

Beasley, Jessica

Abstract/Description

This work seeks to get a better grasp on translation in favor of doing justice to the book, La Sorella Dell'Ave by Ludovica Ripa di Meana. While the research surrounding translation theory is presented here, this project also included the first few chapters of the translation that this project worked on, with the help of Dr. Silvia Valisa. This research discusses ethical translation, feminist translation, translation decisions, and translation perceptions, specifically pertaining to western... Show moreThis work seeks to get a better grasp on translation in favor of doing justice to the book, La Sorella Dell'Ave by Ludovica Ripa di Meana. While the research surrounding translation theory is presented here, this project also included the first few chapters of the translation that this project worked on, with the help of Dr. Silvia Valisa. This research discusses ethical translation, feminist translation, translation decisions, and translation perceptions, specifically pertaining to western culture. Show less

Date Issued

2018-04-27

Identifier

FSU_libsubv1_scholarship_submission_1524812703_4f6e2250

Format

Thesis

Title

Effects of Perceptual Training in Listeners of Severe Dysarthric Speech.

Creator

McBride-Tobiere, Atiana

Date Issued

2018-04-27

Identifier

FSU_libsubv1_scholarship_submission_1524661751_994cd827

Format

Thesis

Title

The Financial Systems and Assimilation Rates of Chinese Diaspora in the American South.

Creator

Novello, James Giovanni

Date Issued

2018-04-27

Identifier

FSU_libsubv1_scholarship_submission_1524855278_ebb29998

Format

Thesis

Title

Nucleosome Dynamics in a MPP+ Model of Parkinson's Disease.

Creator

Pelt, Joe Williams

Abstract/Description

Deroxyrobnucleic acid (DNA) contains the genetic material of living organisms. Nuclear DNA is packaged into nucleosomes, which are composed of DNA wrapped around positively-charged histone proteins. Nucleosome organization regulates gene expression and has been shown to undergo genome-wide distribution changes in response to external stimuli. Parkinson's disease is a neurodegenerative disease that results in tremors, stooped-gait, and loss of memory. It is caused by the progressive death of... Show moreDeroxyrobnucleic acid (DNA) contains the genetic material of living organisms. Nuclear DNA is packaged into nucleosomes, which are composed of DNA wrapped around positively-charged histone proteins. Nucleosome organization regulates gene expression and has been shown to undergo genome-wide distribution changes in response to external stimuli. Parkinson's disease is a neurodegenerative disease that results in tremors, stooped-gait, and loss of memory. It is caused by the progressive death of dopaminergic cells in the substantia nigra. Studies have shown that major molecular pathways are disrupted in Parkinson models. Our study aims to learn how nucleosome organization is altered as SH-SY5Y neuroblastoma cells are induced with 1-methyl-4-phenylpyridinium iodide (MPP+) to model Parkinson's Disease. DNA has been digested by MNase, and all transcription start sites were isolated for sequencing. We now have proper material to answer important questions about chromatin structure's response to MPP+, which will likely reveal information about the etiology of Parkinson's disease. Show less

Date Issued

2018-04-27

Identifier

FSU_libsubv1_scholarship_submission_1524855392_8fb86dc8

Format

Thesis

Title

Using a Call-Response Occupancy Survey with Brown-headed Nuthatches (Sitta pusilla) to Evaluate the Biological Species Concept.

Creator

Levy, Heather

Date Issued

2018-04-27

Identifier

FSU_libsubv1_scholarship_submission_1524855853_d4be0035

Format

Thesis

Title

Neural Network Analysis of Intraganglia Connectivity Based on Single Cell Segmentation of DTI Data.

The purpose of this study was to compare body composition, bone mineral density (BMD), strength, muscle power, and quality of life in short-term breast cancer survivors (ST-BCS) and long-term breast cancer survivors (LT-BCS). METHODS: Body composition and BMD measures were completed on 17 ST-BCS (57.2  9.3 years) and 26 LT-BCS (62.0  7.2 years) via dual energy X-ray absorptiometry (DXA). Upper body strength was measured by a 1 repetition maximum chest press and lower body strength was... Show moreThe purpose of this study was to compare body composition, bone mineral density (BMD), strength, muscle power, and quality of life in short-term breast cancer survivors (ST-BCS) and long-term breast cancer survivors (LT-BCS). METHODS: Body composition and BMD measures were completed on 17 ST-BCS (57.2  9.3 years) and 26 LT-BCS (62.0  7.2 years) via dual energy X-ray absorptiometry (DXA). Upper body strength was measured by a 1 repetition maximum chest press and lower body strength was assessed using BIODEX isokinetic and isometric leg extension and flexion tests. Muscle power was measured by a Tendo unit and quality of life was assessed by the SF-36 questionnaire. RESULTS: Mean time since completion of primary treatment was 7.7  7.1 years. Time since treatment completion for ST-BCS and LT-BCS was 1.8  1.1 years and 11.5  6.7 years, respectively. No significant differences were found between ST-BCS and LT-BCS in measures of body composition, BMD, strength, muscle power, or quality of life. A positive correlation was observed between time since completion of treatment and lumbar spine BMD (r=.38). CONCLUSION: Our findings show that ST-BCS and LT-BCS experience similar rates of changes in body composition, BMD, strength, power, and quality of life, regardless of time since the completion of treatment. This may be due to the similarity in menopausal age between the ST-BCS and LT-BCS in this study. Both may have experienced the same rate of age-related changes since the onset of menopause, as well as similar changes during the cancer treatment period. More research is needed to determine what factors influenced the changes specifically in the lumbar spine BMD over time. Furthermore, more research is needed comparing ST-BCS and LT-BCS to determine whether the effects of treatment persist over time and for how long. Show less

Date Issued

2018-04-27

Identifier

FSU_libsubv1_scholarship_submission_1524885285_d9701640

Format

Thesis

Title

Investigating the link between proteasome dysfunction and human islet polypeptide toxicity in a transgenic yeast model.

Catecholaminergic polymorphic ventricular tachycardia (CPVT), also called exercise-induced ventricular tachycardia is a hereditary disease that can cause sudden cardiac death in human patients. Interestingly, while patients with CPVT have normal function of the heart at rest, they show life-threatening arrhythmias during physical activity or acute emotional stress. Autonomic nervous system is known to have a role in arrhythmia pathogenesis, and its response changes with aging. However, little... Show moreCatecholaminergic polymorphic ventricular tachycardia (CPVT), also called exercise-induced ventricular tachycardia is a hereditary disease that can cause sudden cardiac death in human patients. Interestingly, while patients with CPVT have normal function of the heart at rest, they show life-threatening arrhythmias during physical activity or acute emotional stress. Autonomic nervous system is known to have a role in arrhythmia pathogenesis, and its response changes with aging. However, little is known that how autonomic regulation with aging contributes to arrhythmia burdens in CPVT. Methods: To test our hypothesis, we examined ECG recording with a catecholaminergic challenge (isoproterenol, 3mg/kg + caffeine, 120mg/kg) in anesthetized CPVT mice at different age groups (6 weeks old, 12 weeks old, and 48 weeks old). Results: In CPVT mice, the frequency of arrhythmias were increased with aging. The resting heart rate (HR) decreased with aging, whereas the HR response after adrenergic stress was significantly increased. The average RR interval also increased in advanced age, suggesting a possibility of an increased autonomic regulation. Conclusion: We found that arrhythmia incidence worsens by lowering intrinsic HR, and possibly by a modulation of parasympathetic nerve activity in CPVT mice with advanced age. Show less

Date Issued

2018-04-27

Identifier

FSU_libsubv1_scholarship_submission_1525264709_2e0b4d7e

Format

Thesis

Title

Design of a Temperature and Humidity Controlled Chamber.

Creator

Castro, Andrew

Date Issued

2018-04-27

Identifier

FSU_libsubv1_scholarship_submission_1524854210_10209abf

Format

Thesis

Title

Lend Me Your Ears: Artistic Expression as Political Action in Young People.

Creator

Bonahue, Edward

Date Issued

2018-04-27

Identifier

FSU_libsubv1_scholarship_submission_1524864620_e5568482

Format

Thesis

Title

How Memes Construct Realities Through Terministic Screens.

Creator

Khanam, Shaimaa

Abstract/Description

Internet memes are one of the latest developments in the image genre, growing directly out of the digital age. Andrew S. Ross and Damian J. Rivers, in 2017, analyzed how the 2016 election memes functioned to delegitimize the candidates that they represented. I am taking this idea one step further, positing that Internet memes not only delegitimize, but are an important way that identities are constructed for the individuals they depict. Thanks to the Internet, the distribution, circulation,... Show moreInternet memes are one of the latest developments in the image genre, growing directly out of the digital age. Andrew S. Ross and Damian J. Rivers, in 2017, analyzed how the 2016 election memes functioned to delegitimize the candidates that they represented. I am taking this idea one step further, positing that Internet memes not only delegitimize, but are an important way that identities are constructed for the individuals they depict. Thanks to the Internet, the distribution, circulation, and repetition of words, images, and other forms of communication are more readily available, and can happen on a much larger scale than communication prior to the digital age. Focusing on the 2016 election memes of Donald Trump and Hillary Clinton, this work aims to study how the characteristics of a meme, combined with social media and the digital circulation, work together to construct realities for their viewers, and consequently, identities for the individuals they depict. To investigate this, I analyzed four sets of memes from this election cycle – two for each of the major party candidates – against Kenneth Burke’s theory on terministic screens, which suggests that reality is constructed through language in a process of selection, reflection, and deflection. I believe the same thing happens with images. Through analyzing these sets, I believe I have come to a better understanding of what identities were put forth by the images representing these individuals, and how those identities represent “the reality” of how people understood the candidates. I then explore what it means that these ideas were circulated via social media as memes. Show less

Steroid hormones are the largest class of regulatory factors in the mammalian biology. Steroid hormones bind hormone receptors, allowing them to dimerize and function as transcription factors. Frequently this regulation of gene transcription is associated with nucleosome redistribution. Bisphenol-A (BPA) is a common toxin found in many of the plasticids and epoxy resins we use every day. BPA is a thought to be an estradiol mimic, binding to hormone receptors allowing them to dimerize and... Show moreSteroid hormones are the largest class of regulatory factors in the mammalian biology. Steroid hormones bind hormone receptors, allowing them to dimerize and function as transcription factors. Frequently this regulation of gene transcription is associated with nucleosome redistribution. Bisphenol-A (BPA) is a common toxin found in many of the plasticids and epoxy resins we use every day. BPA is a thought to be an estradiol mimic, binding to hormone receptors allowing them to dimerize and function as transcription factors, which stimulate nucleosome redistribution at inappropriate times. However, nucleosome distribution from BPA exposure has not yet been observed. I expect that as BPA mimics estradiol and dysregulates the potential for gene expression, and that monitoring alterations in chromatin structure will give valuable insights into the first steps of this dysregulation. I mapped nucleosome redistribution and nucleosome sensitivity in both untreated cells and cells exposed to BPA to observe any change in nucleosome repositioning and biochemical composition after this stimulus. If BPA functionally acts as an estradiol mimic and is able to change chromatin structure, untimely or unwanted gene expression may result. BPA will be expected to induce remolding in the cell’s chromatin structure and affect the endocrine responsive genes. My results would show how other stimuli could mimic naturally occurring substances and be unexpected regulatory factors in altering our chromatin structure. BPA is one of many persistent toxins readily in our environment that we are exposed to. We found that there are transient nucleosome positional changes with exposure to Estradiol and Bisphenol-A at the -2, -1, TSS, +1 and +2 positions while comparing the two stimuli at the 10-minute post exposure time period. We are especially interested in the nucleosome loss or gain at the +1 position because of its implications for possible gene expression. These results show that there is indeed similar chromatin remodeling behavior between Estradiol and Bisphenol-A to possibly warrant connections to the potential of the cell. This study will be one of the first to propose chromatin remodeling as the underpinnings to Bisphenol-A ability to mimic the natural sex hormone Estradiol. The scientific world is now becoming more aware of how environmental factors and pollutants all around us can have an acute or trans-generational effect on our health and epigenomic regulation. Show less