Aviva Premiership league-leaders Harlequins welcome Bath to the Twickenham Stoop on Friday evening in round two of the Anglo-Welsh Cup.

Quins opened up their Anglo-Welsh Cup campaign with a thrilling 31-30 victory over Northampton Saints last weekend with Ben Botica scoring and converting a last-minute try to snatch victory away from the Saints who fought back to within touching distance from 21-6 down. And they have made four changes to the side ahead of welcoming Bath with Tom Williams starting at fullback and Jordan Turner-Hall and George Lowe named in the centres. Joe Gray starts at hooker while Luke Wallace retains the captaincy.

Bath also opened their Cup campaign with a win - they defeated the Dragons 36-15 at the Rec. Semesa Rokoduguni crossed for two tries last Saturday but he will have to be content with a spot on the bench for Saturday's match. Kyle Eastmond and Tom Biggs start on the flanks while Ben Williams fills in for the injured Dan Hipkiss in the centres. Chris Cook gets the nod at scrum-half and he will partner Stephen Donald. Lee Mears captains the team from hooker while Dave Attwood and Dom Day line up in the second-row. And Will Skuse is also handed a start and will replace Josh Ovens at blindside.

Elsewhere on Friday evening, Saracens travel to the Salford City Stadium to face the Sale Sharks. Sale lost to London Irish 34-28 last weekend and they have made eight changes ahead of this weekend's game. Former Wallabies back Cameron Shepherd gets the nod at fullback with Corne Uys and Jordan Davies forming a new look centre partnership. Mark Cueto starts on the wing with Danny Cipriani retained at fly-half. In the forwards, Eifion Lewis-Roberts is at loose-head while Joe Ward and Tony Buckley also come into the front-row. And Fraser McKenzie, James Gaskell and Richie Vernon all retain their places in the back-five with Kearnan Myall and David Seymour coming into the team.

Sarries have opted to make four changes from the side that defeated the Tigers last Friday with Lorenzo Romano, Kameli Ratuvou, Joel Tomkins and Mouritz Botha all coming into the team with five further changes on the bench. Hooker Scott Spurling comes into the matchday 23 along with Jackson Wray and David Strettle while prop Rick Reeves and scrum half Ali Price, who are on loan from Bedford Blues, are also named amongst the replacements.

On Saturday, London Welsh travel to Gloucester having made 11 changes for a game that they must win to keep their hopes alive in the competition. Among the changes, Tom Voyce moves to full-back to make space for Dan Caprice to start on the wing while Jamie Stephenson, on loan from London Scottish, starts at scrum-half with Nick Runciman on the bench. Tom Bristow, Will Hafu and Paulica Ion make up the front row and Adam Brown and Matt Corker pack down at lock in an all-new tight-five. Gloucester are boosted by the returns of Freddie Burns, Ben Morgan and Billy Twelvetrees for the crucial clash. Fiji flanker Akapusi Qera is also back in club colours.

Exeter Chiefs make three changs as they host the Ospreys at Sandy Park. All the changes come in the front row as props Luke Cowan-Dickie and Hoani Tui and hooker Jack Yeandle form a new union while the backs remain unchanged. Flanker Arthur Ellis and prop Owen Williams make their debuts for the Ospreys, who are without seven Wales squad members. Prop Ryan Bevington and lock Lloyd Peers have been released from the Wales squad, though, and are on the bench. Fly-half Sam Davies and lock Sam Williams make their first Ospreys starts.

In Wales there is an all-Welsh derby with the Cardiff Blues facing the Scarlets at the Parc Y Scarlets. Cardiff make seven changes to the side that beat Wasps, including Harry Robinson returning from the Wales squad to start on the wing, Rob Lewis starting at scrum half in place of the injured Lewis Jones and Andries Pretorius captaining the side from No.8. The Scarlets are bolstered by the returns of full-back Liam Williams, hooker Kirby Myhill and tight-head Samson Lee while Dan Newton returns from injury to take over at No.10.

On Sunday, the Leicester Tigers play London Irish at Welford Road. Rob Hawkins and Brett Deacon return from injury for the Tigers while scrum-half Micky Young starts for the first time at home this season, Dan Bowden starts at inside centre and Mathew Tait continues his return from a lengthy injury absence with another start at full-back. London Irish include Alex Corbisiero and Jonathan Joseph after they were released by England. Scott Lawson starts at hooker with Matt Garvey and George Skirvington in the second row and Alex Gray packing down at No.8.

London Wasps make six changes to their starting XV as they host the Worcester Warriors. With Marco Wentzel out injured and Joe Launchbury and Tom Palmer with England, Wasps have called up Josh Brown from London Scottish. Matt Everard makes his first competitive start this season at openside flanker with James Haskell on the bench. Tom Lindsay and Ashley Johnson return to the team after being rested last weekend. Worcester make five changes including a new-look front row of Ceri Jones, Ollie Hayes and Rob O'Donnell. Craig Gillies is named in the second row alongside captain Dean Schofield while Errie Claassens is the only change in the backs.

The weekend's line-up is completed by the Dragons' match with the Northampton Saints in Newport. Phil Dowson makes his 100th appearance for the Saints while Ken Pisi, Dom Waldouck, Lee Dickson and Samu Manoa all return following their agonising defeat to Harlequins last time out. Dan Evans makes his first start at fly-half for the Dragons, and starts alongside scrum-half Wayne Evans, who has recovered from a back injury. Hugh Gustafson, Owen Evans, Adam Jones, Nic Cudd and Ieuan Jones all start while Tom Prydie replaces Hallam Amos at fullback.