All Borg drones were equipped with neural interfaces with which to communicate with the rest of the Collective. In 2375, Seven of Nine initiated a direct neural interface with One, a drone enhanced with 29th century technology, in order to download him with instructions. One subsequently began probing Seven's neural pathways in an attempt to assimilate all of her knowledge. This posed a threat to Seven, who asked One to stop before he damaged her, a request which One granted. (VOY: "Drone")

The next year, Seven linked her neural interface with a group of three former drones, in an attempt to restore their memories of the events which linked them together into a collective triad. That same year, Mezoti, a young girl whom the Voyager crew had liberated from the Collective, revealed to Seven that Azan, another former drone, was using his neural interface to cheat at kadis-kot, by relaying information to his twin brother, Rebi. In response, Seven ordered them to exercise Punishment Protocol 9-Alpha. (VOY: "Survival Instinct", "Ashes to Ashes")

In an alternate2392, The Doctor invented a synaptic transceiver, a small implant which allowed a user to pilot a vessel equipped with a neural interface using only their mind. In 2404 of this timeline, Janeway, by this point an admiral, utilized this technology to great effect in her mission to travel back in time to 2378 in her attempt to change history. She later used it to project her image into the Borg Queen's chamber as part of her plot to destroy the Collective. (VOY: "Endgame")