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Critically evaluates the literature on hormonally active agents in the environment and identifies known and suspected toxicologic mechanisms and effects of fish wildlife and humans examines whether and how exposure to hormonally active agents occurs in diet in pharmaceuticals from industrial releases into the environment and why the . In recent years there has been increasing concern regarding potential adverse human health effects of various environmental contaminants designated by some scientists as endocrine disruptors thomas and colborn 1992 colborn et al 1993 and referred to in this report as hormonally active agents haas. Hormonally active agents in the environment 1999 determining the risk of environmental haas to humans and wildlife is difficult because exposure to these agents has not been routinely monitored and effects that might be attributed to background concentrations could be complicated by endogenous hormones pharmacologic estrogens eg . Critically evaluates the literature on hormonally active agents in the environment and identifies known and suspected toxicologic mechanisms and effects of fish wildlife and humans examines whether and how exposure to hormonally active agents occurs in diet in pharmaceuticals from industrial releases into the environment and why the . Hormonally active agents haas include a wide variety of chemicals that mimic the actions of sex hormones and have been associated with adverse reproductive and developmental effects in wildlife exposure can occur from a variety of sources