Brennan (Emily Deschanel), Cam (Tamara Taylor) and Hodgins (TJ Thyne) are locked in the lab by a group of mysterious government agents led by Mr. White (guest star Richard T. Jones) who force them to identify the cause of death for a highly classified set of remains. As the team examines the skeleton, they begin to suspect that they are investigating one of the most famous presidential assassinations in history.

While Brennan explores the dubious parameters placed on her and the Jeffersonian team, Booth (David Boreanaz) and his boss Andrew Hacker (guest star Diedrich Bader) attempt to break into the lab and determine the motive behind the clandestine investigation.

Meanwhile, Cam is distressed about Michelle, who seems to be keeping a big secret from her.