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Horu Horu no Mi

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The Horu Horu no Mi is a Paramecia-type Devil Fruit that grants the user the ability to create and control special hormones that can affect anyone they strike by however the user desires, making the user a Hormone Controlling Human (ホルモン自在人間,Horumon Jizai Ningen?).[2] It was eaten by Emporio Ivankov.

The major strength of the fruit, as demonstrated by Iva, is to create and manipulate special hormones. These hormones can manipulate various aspects of a person such as gender, body temperature, pigmentation, growth, and even emotional state. The hormones can also be used to greatly increase a person's battle capabilities through healing and energizing. By turning four of their fingers into syringes and stabbing a person, the user is able to inject these hormones and change the person on a genetic level to whatever the user desires. This process can also be used by the user on themselves to aid them. The fruit is unable to penetrate Devil Fruit users who can harden their bodies.[citation needed]

Other than that, the fruit seems to have no other weaknesses outside the standard Devil Fruit weakness.[3]

The fruit's bestowed hormone powers, as used by Iva, have been used for a variety of reasons. Iva seems to enjoy playing around with the concept of "gender" as he and his ally Inazuma are seen switching in and out their male and female forms. In addition, supposedly all the Newkamas of level 5.5 have switched sexes. Though Iva enjoys playing around with his powers, they can also make him a powerfully persistent opponent in battle. Iva has clashed with the likes of Akainu and Magellan and has come out of these battles with little harm, despite the deadly abilities of both opponents. Iva's quick recoveries can be assumed to be due to his ability to greatly heal and energize his body through hormones.

The fruit's powers are the source of Ivankov's "miraculous" reputation, which, aside from gender changing, allow Iva to perform other miracles on people besides himself such as extreme healing, using them to allow for a body to adjust from a fatal-condition to having a chance of survival. However, while he can make the adjustment within the body to heal from these conditions, the miracle is also dependent on the person hit by the altering hormones, whereas only those with a strong enough will can survive and use their survival instincts via the hormones to their advantage. Depending on what the conditions the patient is in, as well as the hormones used, the receiver may suffer a shortening of lifespan in exchange for a "cure".

The named techniques that are used by Emporio Ivankov that involve the Devil Fruit are as follows:

Emporio Onna Hormone.

Emporio Onna Hormone (エンポリオ･女ホルモン,Enporio Onna Horumon?, literally meaning "Emporio Female Hormone"): By injecting a male with special female hormones, Iva is able to transform them completely into a female. In the Viz Manga, this is called Emporio Estrogen, and in the FUNimation dub it is called Emporio Female Hormone. This was first seen being used on Bellett who was trying to get revenge on Iva.[1] He can also use this on himself, doing so when he fights Sadi.

In addition, Iva was able to transform himself and other women (supposedly) into men, but this usage for his ability is not a named technique. It appears that this technique does not affect the clothes of the user as every time someone is hit with this technique their physical appearance changes, but their clothes seem to remain but as appearance is changed, their clothes may be too small or big for them.

Emporio Chiyu Hormone (エンポリオ･治癒ホルモン,Enporio Chiyu Horumon?, literally meaning "Emporio Healing Hormone"): By injecting special hormones meant to release the body's immune system's full potential into a sick person, Iva is able to cure them. This is the secret to his "miracle" healing. Since the hormones only unleash the immune system's potential, the chance of survival is mostly based upon the individual's will to live. In order to use this technique, a certain amount of the target's life-span must be sacrificed in order to compensate for the energy used to heal the damage. In the case of Luffy's injuries, it took 10 years of his life-span. In the case of things like poison it seems to make them immune to the very ailment that plagued them. In the Viz Manga, this is called Emporio Healing Synthesis, while in the FUNimation dub it is called Emporio Healing Hormone. This was first seen being used on Luffy to counteract Magellan's poison.[4]

Emporio Tension Hormone (エンポリオ･テンションホルモン,Enporio Tenshon Horumon?): By injecting special adrenaline affecting hormones, Ivankov can provide a tired person with a supply of adrenaline that can relieve tension and allow for easier movement for an entire day. There is an aftereffect after being injected with this hormone, which causes the user to feel nausea and tired. There is a limit to how much fatigue the hormones can relieve, as Ivankov warned Luffy that he would not be getting up again after receiving a second dose. This is called Emporio Energy Synthesis in the Viz Manga and Emporio Energy Hormone in the FUNimation subs and dub. This was first seen being used on an exhausted Luffy.[5] Ivankov has also used this together with Emporio Healing Hormones to recover quickly from fatal poisoning.[6]

Emporio Ganmen Seicho Hormone.

Emporio Ganmen Seicho Hormone (エンポリオ・顔面成長ホルモン,Enporio Ganmen Seichō Horumon?, literally meaning "Emporio Face Growth Hormone"): By injecting special face manipulating hormones, Ivankov can make a person's face expand to enormous proportions that surpass even giants. This is called Emporio Face Growth Synthesis in the Viz Manga and FUNimation subs and dub. This was first seen used by Ivankov on himself during the escape from Impel Down level 4 to make his Death Wink technique into a more powerful version called Hell Wink.[7] While his head is in this state, it allows his hair to hold up to at least 235 people inside it.[8]

The Devil Fruit's gender changing hormones were first seen being used on a male prisoner. In the magazine serialization of the Viz Manga, when the guy was changed into a girl, a top was added to her for censorship reasons despite the guy appearing shirtless earlier.

In a SBS, a fan asked Oda if he would draw the Straw Hats as they would if they were genderswapped by Iva's hormones. In response, Oda provided the following drawings. For the male crewmembers turned female, they would use a typical Japanese feminine style of talking. The opposite is also said for the female crew members with them using a typical Japanese masculine style of talking. Female Luffy is apparently a vegetarian. Female Zoro apparently does not like putting a sword in her mouth as it would chip her teeth. Female Sanji's specialty would be sweets. For most of the Straw Hats, the genderswap is very apparent. Brook however is not so apparent since he has no flesh to help identify whether he was injected with Iva's gender changing hormones or not.[9]

This power is an exaggeration, but not complete fabrication, of what hormones actually can do. Hormones really do control many biological functions in the body, including (but not limited to) growth, behavior, energy, and secondary sex characteristics.