If stimulate locus coeruleus in animals will give fear response!
If give patients an alpha antagonist they have more panic attacks, but don’t know for sure
Panic disorder associated with increased activity and sensitivity of noradrenergic system

3) (GABA) - Benzodiazepine Receptor System
Similarly the GABA system = inhibitory system
Benzodiazepines bind to GABA-A receptor and decreased binding to this receptor lead to panic disorder
Ergo felt there are FEWER GABA-A RECEPTORS --> LESS GABA -->PANIC!