First, I think this thread is a great idea. For the life of me, I can't understand anyone trying to shoot holes in it.

As consideration for the list - I would suggest Potassium Bicarbonate.

The Linus Pauling Institute has some interesting things to say regarding its potential for cardio protection.

If you were considering using it instead of NaHCO3 (preworkout), here is something to consider:

Originally Posted by Adel

Can I use potassium bicarbonate instead? NO! You can combine both, but from a physiological standpoint it does not makes sense to increase your serum potassium levels before a workout, because especially strength training will leech potassium from the cells into the blood anyways. Moreover your body conserves potassium pretty well during a workout, while you lose a comparably large amount of sodium in your sweat. In other words, you risk offsetting the peculiar balance of the extra-cellular sodium ions and the intracellular potassium ions. While weakness or skeletal muscle hyperexcitability would be rather harmless, but certainly ergolytic consequences, this can - in the worst case - lead to bradycardia (=abnormally slow heartbeats), arrhythmias and even sudden cardiac arrest as it was observed in the two "salt-phobic" bodybuilders in the case report I already cited in the comments on the "Sodium Bicarbonate for High Volume Strength Training" post (cf. John. 2011; there were probably confounding factors at play, here, but still, the risk of developing hyperkalemia is nothing you can totally exclude, if you ingest tons of potassium within a couple of minutes).
If you feel that you don't get enough potassium in your diet, anyway, I'd suggest you mix them at a 3:1 ratio as you usually see it for "normal" sodium and potassium in electrolyte products.

I have been using a relatively small amount of sodium bicarbonate with certain supplements because, frankly, some of them give me an emergent gastro-intestinal issue when taken on an empty stomach - and anecdotally I have found this is lessened with sodium bicarb.

So, it seems as if I want to supplement with potassium bicarbonate, the recommendation would be to do so sparingly, and at a 3 to 1 ratio; sodium to potassium.

Thank the reply rob112 please understand when say am I trying to understand mechanism in action for ingredients causing some to list the above because am a person always curious know why to how things work so wish for any contributor also similar in thinking so we may bring light the how then I feel there we will have a better handle on the dose usage.

"To your wife you should kiss try today"-Touey
Brotato's bark brings shakes to the pups in the yard

Thank the reply rob112 please understand when say am I trying to understand mechanism in action for ingredients causing some to list the above because am a person always curious know why to how things work so wish for any contributor also similar in thinking so we may bring light the how then I feel there we will have a better handle on the usage.

I hear you on this, what I was really getting at is I don't believe the evidence outside of forum anecdote exists. It's just not there. You probably won't get much response unfortunately because when you talk about these ingredients you really only single out one product. When you discuss "insert any other supplement ingredient" you can get discussion without and worries of singling out a company or product.

I hear you on this, what I was really getting at is I don't believe the evidence outside of forum anecdote exists. It's just not there. You probably won't get much response unfortunately because when you talk about these ingredients you really only single out one product. When you discuss "insert any other supplement ingredient" you can get discussion without and worries of singling out a company or product.

He's definitely fishing for something, and I don't think its positive discussion.

But, you're right, anecdote is all you'll get on that (I've looked as well).

I hear you on this, what I was really getting at is I don't believe the evidence outside of forum anecdote exists. It's just not there. You probably won't get much response unfortunately because when you talk about these ingredients you really only single out one product. When you discuss "insert any other supplement ingredient" you can get discussion without and worries of singling out a company or product.

Yes what you say makes much sense I have wonder some times that company such as SNS would make each separately in bulk form am very interested in understanding some ideas or surely some must have theories perhaps on how these are working.

"To your wife you should kiss try today"-Touey
Brotato's bark brings shakes to the pups in the yard

He's definitely fishing for something, and I don't think its positive discussion.

Know everyone making joke here all the time perhaps though for while we will try to honest and work all together to better understanding the how in the way compositions work. I think when we are all being honest to helping one another we will have only positive discussion.

"To your wife you should kiss try today"-Touey
Brotato's bark brings shakes to the pups in the yard

Know everyone making joke here all the time perhaps though for while we will try to honest and work all together to better understanding the how in the way compositions work. I think when we are all being honest to helping one another we will have only positive discussion.

You're alright Touey don't worry about it man... that's exactly the point of this thread

No, unless you have cognitive decline or mt disorders that require supraphysiological doses of creatine for phosphate donation and/or allosteric modulation of the NMDA receptor. I hate to say it but the examine.com authors are data miners...they don't know how to interpret it. Creatine has a saturating effect, so according to them, we can never take agmatine period if we want to boost cognitive function, even if our last creatine dose was 12 hours ago. Agmatine will block the NMDA receptor in a manner independent of creatine's allosterism, so there is no real antagonism, just independent effects

Good info man, thanks for dropping in. Deff good to have you as part of the roundtable

No, unless you have cognitive decline or mt disorders that require supraphysiological doses of creatine for phosphate donation and/or allosteric modulation of the NMDA receptor. I hate to say it but the examine.com authors are data miners...they don't know how to interpret it. Creatine has a saturating effect, so according to them, we can never take agmatine period if we want to boost cognitive function, even if our last creatine dose was 12 hours ago. Agmatine will block the NMDA receptor in a manner independent of creatine's allosterism, so there is no real antagonism, just independent effects

That's an over-simplification (I'm from Examine.com).

We said it does not go well with it because it *can* compete. By no means did we imply that they will counteract each other permanently. If you take them at the same time, there can be competition, but we don't exactly know how much would be wasted.

At the same time - our site has an open discussion. If you think something is wrong, tell us.