No differences in the types
of infiltrating cells or myelin destruction in the central nervous system
were found between Jnk2(-/-) and wild-type mice, indicating that lack of
Jnk2 does not alter the effector phase of EAE.

Our results suggest that,
despite involvement in T(h)1/T(h)2 differentiation in vitro, Jnk2 is necessary
neither for the induction nor effector phase of MOG35-55-induced EAE and
nor is it required for antigen-specific IFN-gamma production.