Brown suffered the injury in the fourth quarter after rushing for 64 yards on 13 carries.

"He's been running the ball hard the last week. It's going to be a tough loss," Giants quarterback Eli Manning said after the game.

The second-year back from North Carolina State had emerged as the team's No. 2 back behind Ahmad Bradshaw, rushing for 385 yards and eight touchdowns on the season. The Giants will now have to depend more on rookie first-round pick David Wilson.