Although Federer won the first three games, he endured an awkward fall after leaping for an early overhead and seemed to be struggling for his usual rhythm from the outset.

The 29-year-old, who was born in Brisbane and is now ranked 55th in the world, was up two sets to one against the Swiss juggernaut and prevailed in a gripping fourth-set tie-break to win 3-6, 7-5, 7-6. 7-6. "When you go out on the court, I think it's about engaging in a battle". "I have so much respect for Roger and everything he's done for the game".

The victory sees the world number 55 moving through to a quarter-final clash with Wimbledon champion Novak Djokovic.

The 32 degree celsius heat, though, is much tougher on Djokovic, who showed the same blank expression, rosy cheeks and sweat-soaked shirt as during his first-round match last week.

Prior to this match Federer had not lost a set as he he continues his chase for a sixth US Open triumph and 21st grand slam title. In fact, he has never won an ATP event, falling in the final to Marco Cecchinato of the Hungarian Open earlier in April, according to a report on the website of US Open.

In the women's draw, Madison Keys eased into the quarter-finals with a 6-1, 6-3 victory over Slovakia's Dominika Cibulkova.

Defeating Mikhail Kukushkin 6-4, 4-6, 6-1, 6-3 previously, the young Aussie had to be booted off the court because there were so many people lining up for autographs and photographs.

There was that sort of respite during No. 20 Naomi Osaka's 6-3, 2-6, 6-4 win against No. 26 Aryna Sabalenka, a matchup between two powerful players seeking a first Grand Slam quarterfinal appearance. She still and looked tired to start the second, leaning on her racket between points while falling behind 2-0.

"I felt like a bit of a deer in headlights to begin with, to be honest with you", Millman said.

The Ukrainian got some help from her opponent.

However, the 37-year-old Swiss delivered a strangely lethargic performance on Arthur Ashe Stadium - prompting some pundits to question whether he was 100 per cent fit - and Millman capitalised superbly to earn the biggest win of his career by far.

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