Abstract

The possibilities of using locally available two Iraqi clays kaolin and attapulgite are have been investigated for adsorption of model drug solution of enalapril maleate. U.V. spectrophotometric technique has been utilized to produce quantitative adsorption data at different temperatures. The effect of acidity on the quantity adsorbed of this drug was investigated at Ph = 1.2 in an attempt to simulate the acidity of gastric fluid and at neutral pH. The possible effect of ionic strength on the amount of drug being adsorbed was studied using normal saline at different concentrations. The equilibrium adsorption contact times were determined for both two adsorbents used adsorption isotherms have been analyzed by the Freundlich and Langmuir models. The results of these studies demonstrated that enalapril maleate is adsorbed by both kaolin and attapuligate surfaces, and these two surfaces can be used as a physical antidotes against poisoning by the above drug overdose in vitro.

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