ADEM

ADEM

Acute Disseminated Encephalomyelitis

An acute encephalopathy which usually follows viral infection (1:1,000 cases of measles), bacterial or parasitic infections, or rarely vaccinations (1:106 measles vaccinations) and which is characterised by autoimmune demyelination involving the entire brain, especially the subcortical and central white matter and cortical gray-white junction and spinal cord or may focally affect a nerve or cord root, and is regarded by some as a multiple sclerosis borderline disease.Epidemiology Affects 8/106/year, primarily children.Clinical finding Meningial signs and, if serious, coma and death. Treatment NoneMortality & morbidity 5% mortality; up to 75% recover completely and the rest have only minor residual defects.

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