Targeted profiling and quantitation solutions

Identified biomarkers from either untargeted metabolomics experiments, or hypothesis-driven from the literature, can be verified or validated where usually a limited number of compounds are quantified in a large set of samples.

For highest selectivity and confirmation, HRAM Orbitrap mass spectrometry is the technology of choice for verification of putative biomarkers. Moving through to high-throughput quantitation, SRM analysis on the TSQ triple quadrupole mass spectrometers is the solution of choice.

Popular metabolomics products

Standardized and quantitative HRAM LC-MS metabolomics workflow

Targeted metabolomics offers researchers the possibility to quantify selected metabolites. The AbsoluteIDQ® p400 HR Kit is the first standardized solution for broad metabolic and lipid profiling developed for Thermo Scientific high-resolution, accurate mass (HRAM) Orbitrap MS. It covers hundreds of metabolites while providing quantification, reproducibility, and high throughput. The kit offers the opportunity to analyze various biological matrices from multiple species.

Data analysis

MetIDQ™ highly automates the whole FIA-MS and LC-MS process from project and sample administration to plate layout and work list generation, technical validation and statistical analysis to standardize metabolomics project data processing. MetIDQ is an integral part of all AbsoluteIDQ® Kits.