Analysis of affinity-captured Hrd1 complexes from these cells by size-exclusion chromatography, immunodepletion, and absolute quantification mass spectrometry identified two major high-molecular-mass complexes with distinct sets of interacting proteins and variable stoichiometries, suggesting a hitherto unrecognized heterogeneity in the functional units of Hrd1-mediated protein degradation.

This study provides new knowledge of the CFTR (show CFTR Antibodies) biosynthetic pathway. It suggests that SYVN1 and FBXO2 (show FBXO2 Antibodies) represent two distinct multiprotein complexes that may degrade DeltaF508-CFTR (show CFTR Antibodies) in airway epithelia and identifies a new role for NEDD8 (show NEDD8 Antibodies) in regulating DeltaF508-CFTR (show CFTR Antibodies) ubiquitination.

Study shows that mir125b is up-regulated in osteoarthritis (OA) and inversely correlated with SYNV1 expression. Also, findings demonstrated that miR (show MLXIP Antibodies)- 125b-5p could promote apoptosis of synovial cells through targeting the SYVN1 gene, and the excessive apoptosis of synovial cells could contribute to the development of OA.

results indicate that Hrd1 plays an important role in the maturation of collagen I in renal fibrosis, and that Sec23A (show SEC23A Antibodies) pathway is required for ER-to-Golgi procollagen trafficking to promote collagen synthesis

Synovial Apoptosis Inhibitor 1, Synoviolin (SYVN1) Antigen Profile

Antigen Summary

This gene encodes a protein involved in endoplasmic reticulum (ER)-associated degradation. The encoded protein removes unfolded proteins, accumulated during ER stress, by retrograde transport to the cytosol from the ER. This protein also uses the ubiquitin-proteasome system for additional degradation of unfolded proteins. Sequence analysis identified two transcript variants that encode different isoforms.