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Hi, I have some naïve thoughts about this situation: If it is an RNA pol, it may be helping maintain/regulate RNA levels in cytosol by e.g. recharging decaying RNA levels in cytosols for extended translation. If it is a DNA pol, it might be a long surviving vestigial remnant of bacterial ancestry. I...

Hi, I recently read a paper, "PrimPol, an Archaic Primase/Polymerase Operating in Human Cells" by Garcia-Gomez et al. This polymerase was largely localized to the cytosol - I'm wondering if anyone has ideas as to why that would be the case ...

... go into a little more detail about how the replication works? Or link me to a website? Is it still the same with helicase unwinding the DNA and primase coming in and etc. like in regular DNA replication?

Will the Okazaki fragment in Topoisomerase DNA replication always be between the primase and the ligase protein complexes on the lagging strand? Are there any exceptions to this?? Thanks very much, Billy :D