Kraft Lawrence, a 25 year old peddler travelling from town to town selling and buying various things to make a living during a period much like Europe in the Middle Ages.

One night when stopped at the town of Pasroe, he finds in his wagon a 250 year old pagan wolf deity girl named Holo. She appears to be that of a 15 year old girl, except for a wolf tail and ears. She introduces herself as the town's goddess of harvest who has kept it blessed with good harvests of wheat for many years. Despite having the responsibility to watch over the town, she wants to go back to her homeland in the north called Yoitsu, she believes the people have already forsaken her anyway and that she has kept her promise to maintain the good harvests. She manages to bargain her way out of the village by making a deal with Lawrence to take her with him.

As they travel, her wisdom helps increase his profits, but at the same time, her true nature draws unwanted attention from the church.

Spice & Wolf Season
2: The journey through the wild countryside continues for the merchant Lawrence and his traveling companion, Holo the untamed harvest goddess. As their winding path takes them from village to village, Lawrence and Holo reap the bounty of an ever-strengthening bond, depending on his street smarts and her animal instincts to lead them to the feisty deity's northern home.
Contains episodes 00-12.