Eponine models consist of a set of DNA weight matrices recognizing specific sequence motifs. Each of these is
associated with a position distribution relative to the transcription start site. The model currently in use on this
server is shown below:

Eponine has been tested by comparing the output with annotated mRNAs from human chromosome 22. From this work, we
estimate that using the default threshold (0.999) it detects >50% of transcription start sites, with around 70%
specificity. However, it does not always predict the direction of transcription correctly -- an effect which seems to
be common among computational TSS finders.

Notes

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