Share

Daily doses of a targeted drug called imatinib mesylate along with regular chemotherapy can almost double the survival rate of children with a high risk type of blood cancer called Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL), says a new study.

Advertisement

Known commercially as Gleevec, imatinib is a pill that's used to treat some adult leukemias and gastrointestinal cancers.

Advertisement

It binds to a specific protein in cancer cells and prevents the cells from proliferating.

"With conventional chemotherapy, the three-year survival rate for children with this high-risk type of leukemia is between 30-35 per cent," said Dr. Kirk Schultz, professor of pediatrics at the University of British Columbia.

"Adding continuous exposure to imatinib for two-and-a-half years made a big difference and increased the survival rates to 87 per cent. The drug was well tolerated and it didn't have any significant side effects," he added.

Since traditional chemotherapy doesn't work well for many children with Ph+ ALL, the standard treatment is blood and marrow transplantation, a life-saving procedure that's associated with a risk of complications.

During the study, researchers recruited 92 children and adolescents between one and 21 years of age with Ph+ ALL and to five different groups that received imatinib for different lengths of time.

The group that received imatinib for more than 280 continuous days had survival rates of 87 per cent, a dramatic improvement over traditional chemotherapy and blood and marrow transplantation.

Groups that received imatinib for 84 and 126 days showed moderate improvement in survival rates, while groups receiving the drug for 42 and 63 days had the same survival rates as current standard treatments.

"Using imatinib plus chemotherapy had a synergistic type of interaction," said Schultz.

"I never expected these results. Although it's very promising, we need to do more follow up to get the five-year survival data and determine the long-term survival.

"We submitted our study for publication earlier instead of waiting because the data was so exciting and this type of leukemia is such high risk," he added.

Your comments are automatically posted once they are submitted. All comments are however constantly reviewed for spam and irrelevant material (such as product or personal advertisements, email addresses, telephone numbers and website address). Such insertions do not conform to our policy and 'Terms of Use' and are either deleted or edited and republished.Please keep your comments brief and relevant.This section may also have questions seeking help. If you have the information you are welcome to respond, but please ensure that the information so provided is genuine and not misleading.

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment.Full Disclaimer