38 PREFACE Dear Colleagues and Researchers, Since the research in chemistry is universal it is necessary to have a good communication between scientists. Congresses play effective roles in providing this communication. Chemistry Congress is one of the most important congresses in our country. The goal of this congress is to bring together academicians and specialists working in the field of chemistry or its applications in universities or research institutes. This congress provides opportunity for scientists to evaluate, share and discuss their research findings and provides an environment to exhi bit the progress in chemical science and industry in our country. Moreover, holding Chemistry Conferences regularly and providing communication between institutions is very important in bringing a new perspective and continuity to the scientific research and establishing new collaborations by supporting scientific activities by social activities. As Muğla Sıtkı Koçman University Chemistry Department, we are proud to hold such an important Congress in the 20th establishment year of our University at one of the most beautiful places in the world, Ölüdeniz. Muğla, which is located in the joint where Karya, known as Steep Country and Likya, known as Light Country civilizations meet, has a unique geography with its multi level, multi cultural heritage and na tural beauty. It has 1124 km long coast lane and 131 coves from Bodrum s orth to Fethiye s east. We are pleased to host you in Muğla at the 26th ational Chemistry Congress with International Participation. This year 950 colleagues from 65 different universities and research centers participated to our congress with 162 oral presentations and 563 poster presentations. Hereby, we would like to thank to all our participants, mentors, and colleagues for their valuable contributions to our Congress by providin g their research results in chemistry and its applications. In these days as a big family, we remember with respect our lost colleagues who made valuable contributions to chemistry and appreciate our mentors who work with devotion to provide better opportunities for next generations. Hereby, we held a special session for celebrating the 90th birthday of Prof.Dr. M. Bahattin Baysal. We wish health and happiness to Bahattin Baysal for years to come and thank to all our mentors and colleagues for their contributions in this session. This year we invited Prof. Dr. Atta-ür Rahman, the president of Pakistan Academy of Sciences and Minister of Science and Technology, who has studies in the field of plant chemistry and rd. Prof. Dr. iyazi Serdar Sarıçiftçi who is known with his research in organic solar cells. We thank them for their participation. iii

39 We thank to the president of Turkish Chemical Manufacturers Association, Timur Erk who represents all the chemistry industrialists worked to make our country second in export of chemical products for their participation. We thank this year s invited speakers Prof. Dr. Mahir Alkan, Prof. Dr. Metin Balcı, Prof. Dr. Ümit Demir, Prof. Dr. Saim Özkar and Prof. Dr. Azmi Telefoncu who are working actively in our universities and representing five main fields in chemistry, for their contribution to our Congress. Also our thanks to all scientific board members, session chairs and colleagues who contribute to our Congress by providing their valuable inputs. We thank to Turkish Chemical Society for their roles and efforts in making this event one of the biggest and recurrent national congresses. We would like to thank first to our faculty member and University Rector Prof. Dr. Mansur Harmandar, and to Muğla Sıtkı Koçman University administration, The Scientific and Technological Research Council of Turkey, Sıtkı Koçman Foundation, ational Boron Research Institute, Ölüdeniz Municipality, and other Firms, Institutions and Foundations providing support and contribution for this event. I would like to express my special thanks to especially Congress Secretariat for their efforts in making this event possible, and those members of the Chemistry Department who contributed. I hope that 26th ational Chemistry Congress with International Participation will be successful in opening up new horizons in the field, shedding light on new research areas and contributing to the Chemistry field in Turkey in terms of advancing the science and technology. I welcome you to our event and wish that this event which takes place in a unique place carrying marks of thousands of years of civilization will be scientifically productive and socially enjoyable for you. Kind Regards, Prof.Dr. Gül Asiye AYÇIK Chairman of Congress iv

47 Transition Metal anoparticles as Catalyst in Hydrogen Generation from Amine Boranes Saim Özkar Department of Chemistry, Middle East Technical University, Ankara, Turkey Boron based compounds have been considered as potential hydrogen storage materials, whereby the key issue is the controllable and fast generation of clean hydrogen for fuel cell applications. The hydrogen generation from such materials can be achieved by catalytic solvolysis or dehydrogenation. Heterogeneous catalysts are preferentially used in these reactions for practical applications. However, the catalytic activity in heterogeneous catalysis is restricted by surface area or, more specifically, by the fraction of catalytically active sites on the catalyst surface which are available for the substrate molecules. An efficient way of increasing the surface area is the use of nanoparticles with controllable size and size distribution. Here, it will be presented that the transition metal (0) nanoparticles can be employed as highly active and long-lived catalyst in hydrogen generation from the boron based hydrogen storage materials. Transition metal (0) nanoparticles were prepared from reduction of the respective precursor metal salt in the presence of anionic or polymeric stabilizer. All of the transition metal (0) nanoparticles prepared in narrow size range of a few nanometers show very high catalytic activity in hydrogen generation from the solvolysis of amine boranes at 25 C. PVP-stabilized Ru (0) and Pd (0) nanoclusters with an average particle size of 2.4 ± 1.2 and 3.2 ± 0.5 nm, respectively, are also highly active and long-lived catalyst in the methanolysis of ammonia borane. Ru (0) nanoclusters provide turnovers over 25 h while Pd (0) nanoclusters provide turnovers over 27 h in hydrogen generation from the methanolysis of ammonia borane at 25 C. Rh (0) nanoclusters of 1.9 ± 0.6 or 2.1 ± 0.6 nm size stabilized by tert-butylammonium octanoate or dimethylammonium hexanoate are superb catalyst in dehydrogenation of ammonia -borane or dimethylamine borane at 25 C, respectively. Ru (0) nanoparticles of 2.9 ± 0.9 nm size stabilized by hydrogen phosphate anion are highly active catalyst in the generation of 3.0 equivalent hydrogen per dimethylamine borane through its hydrolysis providing an initial TF value of 500 h -1 and exceptional catalytic lifetime (TT = ) at 25 C. A new type of supported Rh (0) nanoparticles were prepared from the hydrazine borane reduction of [Rh (cod)cl] 2 within the framework of a polyaminoborane support and found to be the most active supported catalyst in the hydrolysis of ammonia borane at 25 C. Further enhancement in catalytic activity of transition metal (0) nanoclusters in hydrogen generation from boron based compounds could be achieved by preparing them within the highly ordered void spaces of zeolite. Intrazeolite cobalt (0 ), nickel (0 ), ruthenium (0 ), and rhodium (0) nanoclusters, prepared from the reduction of transition metal ions within the 1.3 nm size supercages of zeolite -Y, are very active catalyst in hydrogen generation from the hydrolysis of ammonia-borane at room temperature. The use of transition metal (0) nanoclusters as highly active and long-lived catalyst in hydrogen generation provides a safe way of controllable and fast generation of clean hydrogen for fuel cell applications. 4

49 Turkish Chemical Industry Timur Erk Turkish chemical industry, mainly in the petrochemical, soaps, detergents, fertilizers, pesticides, paint, varnish, synthetic fiber, such as soda ash is composed of a variety of chemical raw materials and consumer goods production plants was carried out. Companies operating in the sector in terms of scale and capital resources vary. An important part of the companies operating in the sector is composed of small and medium-sized enterprises, the large-scale companies and multinationals operating. According to data from TSI, the Turkish chemical industry imports 37.7 billion U.S. dollars in 2011, while exports amounted to U.S. $ 13 billion. This is dependent on the Turkish chemical industry, a sector in terms of raw materials and technology, and hence the nature of the chemical industry investment in import substitution conduct shows of great importance in the coming years. Chemical industry, in terms of the importance of logistics has been localized mainly in coastal areas of the country. Petroleum and petroleum products, detergents, soaps, pharmaceutical chemicals, chemical companies producing products such as paint most of the three major industrial city of Marmara, Istanbul, Kocaeli and Sakarya, Izmir, in the Aegean region showing settlements, fertilizer and petroleum products, many companies in the Mediterranean Region were collected. In addition, the main raw materials in the Mediterranean Region soda, bichromate such as the production centers. Fertilizer factories in the Black Sea region still outstanding. During presentation, which performance must show the chemical industry in order to catch 61. Govennement target s which are being 10 th economy in the world and having an export $ 500 billion in 2023, will be discussed. 6

51 Atomic Size-Controlled Electrochemical Synthesis and Characterization of Compound Semiconductors Ümit Demir Atatürk University Faculty of Sciences Department of Chemistry ptical, electronic, and thermoelectric properties of compound semiconductors are a function of the size of the nanostructured semiconductor and the bulk properties are quite different from the nano -scale properties due to quantum confinement effect [1]. Therefore, the number of research for the development of size-controlled synthesis methods of compound semiconductor-based materials has increased considerably in recent years. Among these methods, electrochemical techniques are promising in terms of feasibility, controllability and cheapness. Materials synthesized by conventional electrochemical methods, however, do not seem to meet the requirements of today's technology. ur group has recently developed a new electrochemical method which allows the synthesis of high quality compound semiconductor materials with desired dimensions [2,3]. The developed electrochemical method is based on simultaneous underpotential deposition (UPD) of precursors that make up the compound semiconductors from the same solution. In this method, one of the species is converted to its complex form; therefore it does not react with the other species to form precipitate in the same solution. Electrochemical deposition is carried out at the electrode surface by atom - by-atom using the common UPD potential of both species without changing the solution and switching the deposition potentials. The practical and size-controlled synthesis method allows the synthesis of compound semiconducting materials with a preferentially oriented and highly crystalline form. This method has been successfully applied for the fabrication of many binary and ternary chalcogenides such as PbS, PbTe, ZnS, CdS, CdTe, Bi 3Te 2, Sb 2Te 3 and (Bi xsb 1-x ) 2Te 3 by our research group [4-6]. The synthesized materials were characterized by X-ray diffraction (XRD ), scanning tunneling microscopy (STM ), atomic force microscopy (AFM ), energy dispersive spectroscopy (EDS ), X-ray photoelectron spectroscopy (XPS ), and UV-Visible-IR absorption spectroscopy, and Fourier transform infrared (FTIR) spectroscopy techniques. This new technique, that allows the atomic-size-controlled synthesis of compound semiconductor, has been used to synthesize thin films in a few nanometers thick, for coating of some very complex systems with compound semiconductor material in nanometer scale [7,8], and for the electrochemical deposition of materials with desired band gap and sizes into lithographically generated patterns [9] from the same solution. REFERECES [1] Ronsencher, E., Fiore, A., Vinter, B., Berger, V. Bois, P., agle, J., Science 271, 168, [2] Öznülüer, T., Erdoğan, İ., Şişman, İ., Demir, Ü. Chem. Mater., 17, 935, [3] Alanyalıoğlu, M., Bayrakçeken, F., Demir, Ü. Electrochim. Acta 54 (26 ), 6554, [4] Öznülüer, T., Erdoğan, I., Demir, Ü. Langmuir 22 (9 ), 4415, [5] Şişman, İ., Alanyalıoğlu, M., Demir, Ü. J. Phys. Chem. C, 111 (6 ), 2670, [6] Erdoğan. İY., Demir Ü. Electrochim. Acta 56, 2385, (2011 ) [7] Zhu, W., Liu, X., Liu, H., Tong, D., Yang, J.,Peng, J. J. Am. Chem. Soc., 132 (36 ), 12619, [8] Gu, C., Xu, H., Park, M., Shannon, C. Langmuir 25, 410, [9] işancı, FB., Demir,Ü. Langmuir 28 (22 ), 8571,

53 Higher Education, Science and Technology: Imperatives for Socio-Economic Development Atta-ur-Rahman* and Iqbal Choudhary * H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan After my appointment as Minister of Science & Technology in 2000 and later Federal Minister/Chairman Higher Education Commission in 2002, I persuaded the government to give a 6000% increase in the budget of science & technology and 2400% increase in the budget of higher education. This allowed us to launch major self-funded programmes to uplift our universities, develop high level S&T manpower and focus on the triple challenges of access, quality and relevance in higher education. Pakistan has made remarkable progress during the period in higher education which has directly impacted scientific research. The increase in scientific research output is nothing short of spectacular 600 per cent increase in scientific publications in international journals and a similar increase in citations in the same period, after decades of stagnation. About 5,000 Ph.D. level scholarships were awarded for study in technologically advanced countries (largest programme ever in the developing world) with about 10 million rupees being spent on each student. Some 3,000 indigenous Ph.D. scholarships were also awarded. A Digital Library was established in Pakistan which is regarded as one of the best digital libraries anywhere in the world: Every student in every public sector university today has access to 45,000 textbooks and research monographs from 220 international publishers as well as to 25,000 international research journals completely free of charge. University enrolment has tripled it had reached to only 270,000 during the 56-year period from 1947 to 2003 but in the subsequent seven-year period from 2004 to 2010, it increased to about 810,000. There were only 59 universities and degree awarding institutes in the year 2001 in Pakistan. These grew to 137 such institutions by Pakistan has won four prestigious international awards in recognition of the rapid transformation in the higher education sector [1]. We have investigated several hundred terrestrial and marine plants for their chemical and biological significance and isolated and identified over 2000 compounds of which some 600 turned out to be new and novel constituents with interesting biological activity profiles. In order to optimize the chances of finding novel leads, extensive primary biological screenings and activity-guided fractionation and purification were carried out. State-of-the-art spectroscopic techniques, especially modern multi-dimensional MR techniques, were utilized to elucidate the structures of bioactive natural molecules, rapidly and accurately. A selection of these results illustrated by their potential application to treat diseases such as epilepsy will be presented. REFERECES [1] 10

59 S-E-002 Removal of 2,4-Dichlorophenol via H 2 2 /UV-C, Fenton and Photo-Fenton Processes: xidation Products and Toxicity Changes Akın Karcı 1, İdil Arslan-Alaton 2, Tuğba Ölmez-Hancı 2, Miray Bekbölet 1 1 Boğaziçi University Institute of Environmental Sciences 2 İstanbul Technical University Faculty of Civil Engineering Environmental Engineering Department ne of the major disadvantages of advanced oxidation processes (AP) which are chemical treatment methods relying on the generation of reactive species, mainly hydroxyl radicals (H ), is known to be the formation of oxidation products being more toxic than the target substances [1]. Considering this information, the present study aimed at examining the changes in oxidation products and acute toxicity, and relationships between these changes during the application of H 2 2/UV-C, Fenton (Fe 2+ /H 2 2) and photo- Fenton (Fe 2+ /H 2 2/UV-C) processes for the degradation of 2,4-dichlorophenol (2,4-DCP ), a priority toxic compound, in aqueous solution. In the first part of the study, treatment performance was evaluated in terms of 2,4-DCP and total organic carbon (TC) removal kinetics. In the second part, dechlorination of 2,4 -DCP and its transformation into various oxidation products under the selected treatment conditions were studied by means o f ion chromatography, high performance liquid chromatography, gas chromatography-mass spectrometry (GC- MS) and colorimetry techniques, while acute toxicity changes were monitored using the marine photobacterium Vibrio fischeri. Vibrio fischeri was selected in this study due to its high sensitivity to a number of industrial pollutants [2]. The most efficient AP in terms of 2,4-DCP and TC removal rates was the photocatalytical photo-fenton treatment (0.260 min -1 and min -1 ) followed by the photochemical H 2 2/UV-C (0.170 min -1 and min -1 ) and chemical Fenton (0.098 min -1 and min -1 ) processes. The common degradation products of the studied treatment processes were the aromatic oxidation product hydroquinone and the aliphatic oxidation products formic, maleic and fumaric acids. In addition, aliphatic aldehydes were formed during the application of all the three processes. H 2 2/UV-C and photo-fenton processes ensured the complete degradation of these oxidation products, whereas Fenton process was less effective particularly for the removal of aliphatic carboxylic acids and aldehydes. Within the scope of the study, some chlorinated oxidation products were identified as chlorohydroquinone, 2,5-dichlorohydroquinone, 4-chlorocatechol and 4,6-dichlororesorcinol as well. The acute toxicity assays revealed that the initial relative inhibition value of 99% decreased to 17% within the first 30 min of the 90 min-h 2 2/UV-C process, whereas the acute toxicity was completely eliminated within the same treatment time of photo-fenton process. n the other hand, 54% relative inhibition was detected at the end of 90 min-fenton treatment. The decrease in acute toxicity during the application of H 2 2/UV-C and photo-fenton processes was related with the 2,4-DCP removal and dechlorination, while the primary source of acute toxicity observed in the Fenton -treated samples was suggested as the carboxylic acids. In conclusion, photo-fenton process was the most efficient AP in terms of both 2,4-DCP and TC removal, and detoxification. Data obtained from this study clearly demonstrated the role of toxicity tests in deciding whether a chemical treatment is sufficient. REFERECES [1] Radjenović, J., Petrović, M. and Barcelό, D. Trends in Analytical Chemistry, 28, , [2] Rizzo, L.Water Research, 45, ,

63 S-E-004 Synthesis of Eight-Membered Ring Aminocyclitols Ayşe Kılıç, Yunus Zozik, Emine Salamcı Department of Chemistry, Faculty of Sciences, Atatürk University, Erzurum, Turkey C8-carbasugars and related aminocyclitols are a class of polyhydroxylated cyclooctanoics. The synthesis of 3- aminocyclooctanetriols (2) and 7-aminocyclooctanepentaol (6), which are analogues of cyclooctanetetrols, are unknown yet. More recently, attention has been increasingly accorded to these aminocyclitols and derivatives since aminocyclooctanepentaols are glycosidase inhibitors. H H H 2 H 2 H H 2 H H H H 1 H 2 3 H 5 H 6 H 2 H 2 H H 2 H 4 Various chemical transformation of cyclooctene endoperoxide obtained by photooxygenation of cis,cis -1,3- cyclooctadiene (1) resulted in 3-aminocyclooctanetriol (2) stereospecific. Reduction of the endoperoxide with zinc followed by mesylation of the hydroxyl group and substition with a 3 gave diazide product. s 4/M oxidation of the double bond in the diazide followed by hydrogenation afforded diaminocyclooctanediol (3) as sole product. Diaminocyclooctanediol (4) will be also synthesized from the endoperoxide in similar approach. In the second part of this study, 1,5-cyclooctadiene (5) was oxidized with m-cpba. The obtained epoxide was treated with a 3 to form the corresponding azidoalcohol. After the acetilization of azidoalcohol, bromination was performed. ow, we aim to obtain 7- aminocyclooctanepentaol (6) by the chemical transformations of the corresponding diene, which will be formed elimination of brominated azidoacetate. Acknowledgment: The authors are indebted to TUBITAK (Scientific and Technological Research Council of Turkey) for their financial support of this work (Grant o: 110T208 and 106T647). REFERECES [1] Gultekin, M. S., Celik, M., Balci, M. Current rganic Chemistry 8, , 2004; Salamci, E., Seçen, H., Sütbeyaz, Y., Balci, M., Journal of rganic Chemistry 62, , [2] Salamci, E. Tetrahedron. 2010, 66, [3] Grabowski, S., Armbruster, J., Prinzbach, H. Tetrahedron Letters 38,

65 S-E-005 Studies on the Synthesis of 2,3,4,9-Tetrahydrocarbazole Compounds Ayşe Uzgören-Baran 1, esimi Uludağ 2, Süleyman Patir 3, Gürol kay 4 1 Hacettepe University, Faculty of Science, Department of Chemistry 2 amık Kemal University, Faculty of Arts and Sciences, Department of Chemistry 3 Hacettepe University, Faculty of Education, Department of Chemistry Education, 4 Siirt University, Faculty of Arts and Sciences, Department of Chemistry The alkaloids are heterocyclic, nitrogen containing compounds with significant biological activity. After scientists find out the biological activity of these compounds, many alkaloids are isolated from plant and characterized. Tetracyclic uleine alkaloids such as uleine, dasycarpidone, noruleine and nordasycarpidone, and pentacyclic strycnos alkaloids such as tubotaiwine, condyfoline and tubotaiwinal are most important alkaloids. When the structure of these alkaloids are examined, it is easily seen that all have same core structure, 2,3,4,9-tetrahydrocarbazole skeleton (1). Therefore the synthesis of these structures are important for organic chemistry. In literature, various synthesis strategies have been devoloped in order to form this structure and to be aimed to synthesis of these compounds with high yield [1-4]. Because of the low yields, it is necessary to devolop of new strategies. Therefore in this study, different strategies were formed for the synthesis of indole alkaloids. The core structure of uleine group alkaloids and pentacyclic strychnos alkaloids, - (Acetyl )-12-ethyl-1,2,3,4,5,6- hexahydro-1,5-methanoazocino[4,3-b]indole were synthesized. Many new tetrahydrocarbazole compunds were also synthesized, purificated and characterized successfully. REFERECES [1] Gracia, J. C., Bonjoch, J., Bosch, J., Journal of rganic Chemistry, 59, , [2] Uludağ,., Hokelek, T. Ve Patır, S., Journal of Heterocyclic Chemistry, 43 (3), , [3] Saito, M., Kawamura, M., gasawara, K., Chemical Communications, 8, , [4] Dolby, L. J., ve Biere, H., Journal of rganic Chemistry, 35, ,

71 S-E-008 Effect of Cooking on utritional Properties and Chemical Composition of Mushrooms Armillaria mellea (Vahl: Fr.) Kumm Ebru Erol 1, Yunus Çetintaş 1, Mehmet Öztürk 1, Mehmet Emin Duru 1 1 Mugla University, Faculty of Science, Department of Chemistry Determination of fatty acid composition of fungi contributes to the disclosure of the nutritional properties of mushrooms. The number of studies on the fatty acids increased parallel to increasing interest in mushrooms. Major compounds in the fungis are straight chain fatty acids [1-3] between C12-C20 and C16-C24 fatty acids with hydroxy groups [1]. Major compounds in the fatty acids of fungi are oleic, linoeic and palmatic acids [1-5]. It is shown that the investigated mushrooms are rich sources of protein and carbohydrates and have low amounts of fat. Wild edible mushrooms are popular to consume as good food sources [6]. Armillaria mellea is a poisonous member of tricholomatacae family and known as honey fungus. In this study, chemical composition and nutritional values of Armillaria mellea collected from Belgrade Forest in Istanbul were investigated. In this study, both raw and cooked mushroom extraction was performed by the method of maceration. Two hexane extracts were obtained. Hexane extracts of these fatty acids were converted to methyl ester derivatives and fatty acids were illuminated by using GC-MS. Moreover, by considering the fact that mushrooms are rich sources of vitamins, proteins, and minerals, Armillaria mellea s nutritional values have been revealed. In determination of mineral content of the mushroom, ICP -MS instrument was used, the Kjeldahl method was used to determine the protein content [7]. The amount of carbohydrate was determined by using the amounts of protein, lipid, and ash and energy value (kcal) was calculated according to the methods of AAC with the use of protein, carbohydrate and lipid amounts. Each test was performed in three parallel. o significant difference was found between the Fatty acid components of cooked and uncooked samples. Heavy metal content of the mushroom was found to be low, and its mineral content was found at ppm level. Protein content was found to be between 17 and 22%. REFERECES [1] Kavıshree, S., Hemavathy, J., Lokesh, B.R., Shashirekha, M.., Rajarathnam S., Fat and fatty acids of Indian edible mushrooms, Food Chemistry, 106: , (2008 ). [2] Senatore, F., Dini, A., Marino, A., Chemical constituents of some basidiomycetes. Journal of Science of Food and Agriculture, 45: , (1988 ). [3] Senatore, F., Fatty acid and free amino acid content of some mushrooms. Journal of Science of Food and Agriculture, 51: 91 96, (1990 ). [4] Stancher, B., Procida, G., Calabrese, M., Characteristics of the most common mushrooms cultivated in Italy. IV. Lipids: Determination of the content of free and bound fatty acids. Industrie Alimentari, 31: ,750, (1992 ). [5] Yılmaz,., Solmaz, M., Türkekul, Ġ., Elmastas, M., Fatty acid composition in some wild edible mushrooms growing in the middle Black Sea region of Turkey, Food Chemistry, 99: , (2006 ). [6] Colak, A., Faiz,., Sesli, E., utritional Composition of Some Wild Edible Mushrooms. Turkish Journal of Biochemistry. 34 (1 ); [7] Kjeldahl Metodu-MEGEP. 28

73 S-E-009 Phytochemical Treasures of Sea Gülaçtı Topçu Bezmialem Vakif University, Faculty of Pharmacy, Department of Pharmacognosy/Phytochemistry, Fatih 34093, İstanbul, Turkey Although marine plants and invertebrates have received considerable attention as a resource for natural - product discovery, this diversity remains yet unexplored. The oceans cover 71% of the earth's surface and harbor most of the planet's biodiversity. Marine natural products have demonstrated significant and extremely potent biological activities. However, in Turkey, only a few groups have studied chemistry [1-4] and bioactivity of marine organisms, although it is surrounded by sea on three sides. Among mar ine plants, algae are at the bottom of the food chain in all aquatic ecosystems, and algal products have an important place in food, cosmetic and pharmaceutical industries. ur group have studied marine plants from the coasts of the Black-Sea, Marmara Sea, Aegean Sea and Mediterranean Sea including Laurencia, Gracilaria, Gelidium and Jania species, and have isolated different types of terpenoids which consist of sesqui-, and diterpenoids [2-3] and steroids [4] as well as some other constituents. Among the investigated species, Laurencia obtusa exhibited high diversity [1-3] for its phytochemicals (see Figure ), which afforded different types of halogenated and non-halogenated sesquiand diterpenes, and acetogenins. Gracilaria verrucosa was found to be rich in fatty acids and steroids while Gelidium latifolium was fairly poor in secondary metabolites. The structures of the isolated compounds were elucidated through spectroscopic analyses, namely 1D- and 2D-MR, Mass, UV and IR techniques. Some of the isolates, investigated for their several biological activities, exhibited medium-high cytotoxic and/or antimalarial activity. Recently, the development of improved cultivation methods and technologies for accessing deep -sea environments promises to provide access to new natural sources including marine bacteria [5] besides marine algae, sponges, corals and and other marine organisms. REFERECES [1] Imre, S. ve ark. Phytochemistry, 20, , [2] ztunc, A. ve ark. Tetrahedron, 47, , [3] Topcu, G. ve ark. J.at.Prod., 66, , [4] Aydogmus, Z. ve ark. at.prod.res., 18, , [5] Fenical, W. ve Jensen, PR. at. Chem. Bio., 2, ,

85 S-E-015 Development of the ew Methodology for the Synthesis of Bis-Aminoinositol alan Korkmaz Çokol 1, Serdal Kaya 1,2, Metin Balcı 1 1 Middle East Technical University, 06800, Chemistry Department, Ankara 2 Giresun University, 28100, Chemistry Department, Giresun Aminocyclitols have drawn attention in recent years due to they have biological activities, pharmaceutical properties and they are used as key compounds for the synthesis of natural compounds [1]. Aminoinositol is one type of cyclitols in which one or more hydroxyl groups are substituted by amine functionality. Aminoinositols have attracted a great deal of attention in recent years for they are capable of using for the synthesis of natural compounds and involved in some antibiotics [2]. In this study, bicyclic molecule (2) was synthesized through the Diels-Alder reaction of furan and was protected via epoxidation reaction. Then, the protected compound was treated with hydrazine monohydrate and amine functionalities were introduced to ring through Curtius Rearrangement. REFERECES: [1] Mehta, G., Mohanrao, R., Katukojvala, S., Landais, Y., Sen, S., Tetrahedron Lett., 52, bbbbb2893, 2011 [2] Serrano, P., Llebaria, A., Delgado, A., J. rg. Chem., 70, 7829,

89 S-E-017 A ew Vision on Electrophilic Cyclization Reactions: btaining of Pyrrolotriazepine Scaffold urettin Mengeş 1,2, Metin Balcı 2 1 Yüzüncü Yıl University, Science Faculty, Chemistry Department, VA 2 Middle East Technical University, Science and Education Faculty, Chemistry Department, AKARA We have witnessed many electrophilic cyclization reactions between any kind of alkyne and metal catalyst. In these processes, many catalysts which are especially transition metal have been used. But, rarely, these processes have been done without using catalyst. Electrophilic cyclization reactions of alkyne have been used to form many natural and synthetic heterocyclic ring which have vital role in metabolism. These rings are furan, pyrone, pyrrole, indole, diazepine. Generally, in electrophilic cyclization reaction which occur with metal is not regio- and chemoselective, so sideproducts take place. Moreover, in electrophilic cyclization of alkyne, many times the reaction mechanism is not so clear [1]. There is no example of pyrrole fused triazepine moiety in literature. And, this outcome force us to obtain triazepine unit, promising in pharmacy, fused pyrrole ring [2]. Scheme 1 In this study, we have envisaged that it might be a good idea to drive a electrophilic cyclization without using any metals to synthesize pyrrolotriazepine skeleton. For this purpose, pyrrole (1) was derivated with carbonyl group at C-2 position and propargyl group at nitrogen atom of pyrrole (2 ). Derivative 2 has been used to drive electrophilic cyclization and some pyrrolotriazepine compounds have been obtained. Furthermore, the reaction mechanism has been lighted by running independent experiments. To sum up, a new method was entered into electrophilic cyclization of alkyne and with this process, pyrrolotriazepine scaffold which has so far unknown has been synthesized. REFERECES : [1] Mehta, S., Waldo, J. P., and Larock, R. C., Journal of rganic Chemistry, 69, , [2] Reayi, A., and Hosmane, R. S., Journal of Medicinal Chemistry, 47, ,

93 S-E-019 Metal Catalyzed Enantioselective Synthesis of rganic Compounds Using FAM and PFAM Chiral Ligands Özdemir Doğan Middle East Technical University, Department of Chemistry, Ankara, TURKEY Asymmetric synthesis of organic compounds is an important field of ornganic chemistry. As the method metal catalyzed asymmetric synthesis has been developed and applied by significant number of researchers worldwide for the last two decades. In this respect we have synthesized new amino alcohol based ferrocenyl aziridinyl methanol (FAM) and phosphorous based phosphino ferrocenyl aziridinyl methanol (PFAM) chiral ligands and used for metal catalyzed asymmetric synthesis of organic compounds [1-3]. These ligands can be synthesized easily on a gram scale starting from acryloyl ferrocene by applying Gabriel-Cromwell reaction. Among the metal-ligand catalyzed enantioselective reactions, diethylzinc addition to aldehydes was carried out to form secondary alcohols in excellent enantioselectivity. Another reaction was alkynylzinc addition to aliphatic and aromatic aldehydes which formed propargylic alcohols also in excellent enantioselectivity. In another reaction 1,3-dipolar cyloaddition of azomethine ylides was carried out to produce pyrrolidines in good yields and enantioselectivities. In the case of nitromethane addition (nitroaldol reaction) to aromatic, aliphatic, α,β-unsaturated, and heteroaromatic aldehydes and β -ketoesters corresponding β -nitroalcohols were obtained in very good yields and enantioselectivities. Diethylzinc addition to enones was also stied which formed β-ethylkeyones in good yields and enantioselectivities. Synthesis of chiral ligands and their application to metal catalyzed enantioselective synthesis of organic compounds will be presented at this conference. REFERECES [1] Dogan, Ö.; Bulut, A.; Polat, S.; Tecimer, M. A. Tetrahedron: Asymmetry, 22, , [2] Eröksüz, S.; Dogan, Ö.; Garner, Philip P. Tetrahedron: Asymmetry, 21, , 2010, [3] Bulut, A.; Aslan, A.; Dogan, Ö. J. rg. Chem. 73, ,

109 S-E-027 The Synthesis and Characterization of Biphenyl Chromen Derivatives the ew Metal-Free and Metallo Phthalocyanine Compounds Ümit Salan 1, Asiye Gök 2 1 Marmara University, Faculty of Science Department of Chemistry, Göztepe Campus İstanbul 2 Marmara University Faculty of Medicine Department of Biochemistry,Haydarpaşa Campus İstanbul Chromen and its derivatives are in the free state and glucosides in plants. Chromens belong to the isoflovonoid class and they are seen in citrus fruits, vegetables, leguminous and orchides. Chromens are pharmacologically active and natural prouducts which are used in the treatment of diverse range of diseases, such as brucellosis, burns, rheumatic disease and even some type of cancer. Phthalocyanines are 18πelectron macrocyclic aromatic compounds consisting of four isoindolin units linked together by nitrogen atoms. Phthalocyanines are capable of incorporating more than 70 different metallic and nonmetallic cations in their ring cavity. Phthalocyanines, have been widely used in very different areas. For example, press ink as a dye and pigment, making coloured metal and plastic surfaces, laser technology, as optical and electrical materials, photodynamic cancer cure and chemical sensor. In this study, according to taking into consideration some important biologic and chemical properties of coumarins and phthalocyanines, it is aimed to synthesize some new phthalocyanines compounds derivative of coumarin and to bring in this compund to the literature. In this study, firstly, 3-(Biphenyl-4-yl)-7-hydroxy-2H-chromen-2-one was synthesized as precursor compound. In the second step, this product were treated with 4-itrophthalonitrile and were obtained 4-(3-Biphenyl-4- yl)-2-oxo-2h-chromen-7-yloxy)phthalonitrile.in the last part of study, the new metal-free and metallo phthalocyanine (H 2Pc, ZnPc, CoPc, InPc) compounds were synthesized from 4-(3-Biphenyl-4-yl)-2-oxo-2Hchromen-7-yloxy )phthalonitrile. Structures of the new synthesized compounds were proved which are based on the results of UV-vis, 1 H-MR and FT-IR spectra. As a result, the original metal and metal-free phthalocyanine new biphenyl derivative of coumarin compounds were synthesized. The data which are obtained in this study are believed to enlighten the researchers in our country and the recent studies in the field of chemistry. 66

113 S-E-029 Research of Chemical Compositions Cooked and Uncooked Tricholoma terreum (Schaeff.: Fr) Kumm. of Mushroom btained Different Extraction Methods Yunus Çetintaş 1, Ebru Erol 1, Mehmet Öztürk 1, Mehmet Emin Duru 1, Mansur Harmandar 1 1 Mugla Sıtkı Kocman University, Faculty of Science Department of Chemistry, Mugla, 48121, Turkey Mushrooms using of as food due to the delicious flavor and aroma and also has been used as drug for medical and biological activities today.mushrooms contains proteins, amino acids, vitamins, minerals and a high proportion of poly-unsaturated fatty acid components.mushrooms have 5% fat and approximately they are unsaturated fatty acid components as 75% this of oil.this feed is more important than fungi.mushrooms was adopted in literature both in terms of chemical composition and have an important nutrient medicinal activity, healthy food.tricholoma terreum (Schaeff.: Fr) Kumm. referred to "Cincile", "Millibars", and "Kuraki mushroom" as the people. Tricholoma terreum is a mushroom species edible and commercial potential of.calcareous soils in clusters, are emerging especially in September, ctober and May. In this study, the collected mushroom samples were divided into two partwhile some of them were cooked, the other part was freshly studied.three different extraction method was applied to cooked and raw mushroom samples (extraction at room temperature, extraction with Soxhlet extraction and ultrasonic bath) and 24 kinds of extracts were obtained by hexane, acetone, methanol and water.the obtained six different hexane extract was converted to methyl esters with BF3: Methanol Reagent and the extracts of methanol and acetone was silylated with Bis (trimethylsilyl )-trifluoracetamid reagent.all of them were analyzed by GC and GC-MS.The results showed that the unsaturated fatty acid content of cooked samples extracts were higher than the raw samples extracts and it was observed that raw sample extracts included less reagent.it was found that the ratio of linoleic acid and oleic acid was higher in cooked samples. REFERECE 1 Senatore F. Fatty acid and free amino acid content of some mushrooms. Journal of the Science of Food and Agriculture. 51,191-96, Agrahar Murugkar D, Subbulakshmi G. utritional value of edible wild, 42-45, Kıvrak İ, Duru ME, Öztürk M, Mercan, Harmandar M, Topçu G. Antioxidant, anticholinesterase and antimicrobial constituents from the essential oil and ethanol extract of Salvia potentillifolia. Food Chemistry 116 (2), ,

117 S-E-032 Synthesis and Properties of Vinyl Esters of Cyclic Carboxylic Acids Aida Shahmammadova 1, Sabir Mustafayev 1, Makhruza Shatirova 2, Mamed Veliyev 2 1 Azerbaijan State il Academy AZ1010, Baku, Azadlyg ave Institute of Polymer Materials of Azerbaijan ational Academy of Sciences AZ5004, Sumgait, S.Vurgun Str The unsaturated esters of cyclic carboxylic acids on its scientific and practical significance attract researchers attention. They are widely used in polymer, paint and varnish industry as the monomers, solvents and plasticizers of the polymer materials and also as the antimicrobial substances, anticorrosion additions to lubricants, corrosion inhibitors, and so on [1]. Continuing investigations in this direction [2,3], in this work the vinyl esters of cyclic carboxylic acids have been synthesized and their properties have been investigated. As a result of the carried out investigations it has been found out that the cyclic monocarboxylic acids interact with vinylacetate in the presence of mercury acetate and etherate of trifluorboron and the corresponding esters with yield of 70-80% on the following scheme are formed: R - C(CH 2 ) n CH + CH 3 CCH = CH 2 BF 3 (C 2 H 5 ) 2 Hg(CH 3 ) 2 R - C(CH 2 ) n CCH = CH 2 +CH 3 CH CH 3 n=1,2; R=naphthene radical,,,, CH, 2 CH 2 The structure of the synthesized unsaturated esters has been confirmed by the spectral methods of IR- and PMR-spectroscopy. It has been proved that the synthesized esters are very reactive compounds and can be widely used in organic synthesis. In particular, it has been known that they undergo the reaction of hydrosilylation, diene condensation, epoxidation with formation of new derivatives. Keywords: carboxylic, vinyl esters, vinylacetate, etherate of trifluorboron REFERECES [1] S.A.Mustafayev. Author s abstract of dis. Doctor of chemical sciences. aphthene acids of Azerbaijan oils and their derivatives preparation, properties and application. Institute of Petrochemical Processes of Azerbaijan ational Academy of Sciences, Baku, 2008, 35 p. [2] M.G.Veliyev, M.I.Shatirova.,.Ya.Ishenko, Z..Guseinova., A.I.Ibragimova // ZHPKH, 2008, V.81, Vyp.6, P [3] M.G.Veliyev, S.A.Mustafayev, A.G.Shahmammadova. / Chemical reactants, reagents and processes of low-tonnage chemistry. Sb.nauchn. tr-ov. Belarus, Minsk-2011, P

119 S-E-034 Polycyclic Aromatic Hydrocarbons (PAH) in Sediments and P. ceanica Meadows of Alexandroupolis Gulf, E Greece Maria- Venetia Apostolopoulou 1, Patrick Roose 2, Pavlopoulos Kosmas 3, Frank Dehairs 1 1 Analytical and Environmental Chemistry, Vrije Universiteit Brussel, Pleinlaan 2, B-1050, Brussels, Belgium, +32 (0) ; 32 (0 ) Management Unit of the orth Sea Mathematical Models and the Scheldt estuary, 3de en 23ste Linieregimentsplein, B-8400 stend, Belgium, +32 (0 ) Geography, Harokopio University, El.Venizelou 70, 17671, Athens, Greece, +30 (0 ) Since March 2007 the construction of an oil pipeline is under deliberation by the governments of Russia, Greece and Bulgaria. The aim is to transport Russian oil through the Black Sea, Bulgaria, Greece and the Aegean Sea to the worldwide market. The present paper, describing sources of organic material in Alexandroupolis Gulf, E Greece, may contribute to setting a baseline for the initial environmental conditions against which future changes can be referenced. Additionally, this study estimates the influence of the flood events transporting terrestrial organic matter into the coastal zone. The paper focuses is on Polycyclic Aromatic Hydrocarbons (PAH) as a proxy of organic matter sources. To achieve this goal PAHs were analyzed in sediment samples and in tissues of the endemic Mediterranean species Posidonia oceanica. Sediments and plants were collected along the coastal area as well as the Evros River and its estuary from 2007 to The PAH concentration was analysed by GC-MS. For total lipid extraction, Soxhlet and pressurized liquid extraction were compared. In addition, sediment and biomass samples were analyzed on EA-IRMS for the determination of TC, TC/T, δ 13 C of bulk TC. PAH compound ratios, such as phenanthrene/anthracene, fluoranthene/pyrene and benz (a)anthracene/chrysene, were calculated to evaluate the relative importance of different origins. ΣPAH concentrations range between 8,2 to 602,1 ng/dw -1 for the sea area and 17,1 to 728,6 ng/dw -1 for Evros River. There is a trend of high ΣPAH values in sediments east to west of Alexandroupolis Gulf and downward of Evros River in which petrogenic origin were also detected. Posidonia oceanica leaves were shown to have higher concentrations of ΣPAHs than other parts of the plant (average 648,6 ng/dw -1 ). Medium Molecular Weight (MMW) and High Molecular Weight (HMW) PAHs, exhibit higher values in the site which is in proximity with Alexandroupolis city and its harbor underlining the use of Posidonia oceanica plant as bio-indicator. Finally, investigating the two different PAH extraction methods, Soxhlet and ASE there was no significant difference between the results obtained. Keywords: Polycyclic Aromatic Hydrocarbons, oil-pipeline, organic matter, P.oceanica 76

125 S-E-040 The Synthesis of aturally ccurring 3,3 - eotrehalosadiamine and its Analogs through Disarmed to Armed And Armed to Super Armed Approach Shazia Anjum, 1,3 J. E. Rubin, 2 and D. R. J. Palmer 1 1 Department of Chemistry, University of Saskatchewan, 110 Science Place, Saskatoon, SK S7 5C9, Canada 2 Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon, SK S7 5B4, Canada 3 Cholistan Institute of Desert Studies, The Islamia University of Bahawalpur, Bahawalpur, Pakistan The synthesis of a naturally occurring 1,1 -disaccharide, neotrehalosadiamine (TD) and its analogs, is described in this report for the first time. Following an 11 step process, seven of which did not require chromatographic separation, TD was generated at an overall yield of 60%. A high yielding, stereoselective synthetic process was developed using the inexpensive, commercially available precursor: 1,2:5,6 -di-isopropylidene-α-d-glucofuranose. The advantage of the participating effect of the acyl group at -2 of donor glycoside was taken in order to build the key α,β-linkage of TD molecule in highly stereoselective manner. The influence of electronic effects of disarmed to armed and armed to super armed glycosyl donor/acceptor on outcome of 1,1 -glycosidation was also observed. The detailed antibacterial studies on neotrehalosadiamine (TD) and its analogs have also been described here in due course. Acknowledgments: Financial support of this work by the SERC Discovery Gra nt to D.R.J.P. and a Saskatchewan Health Research Fund Team Grant to the Molecular Design Research Group is gratefully acknowledged. REFERECES [1] Geyer, A. Reinhardt, S. Bendas, G. Rothe, U. Schmidt, R. R. J. Am. Chem. Soc., 1997, 119, [2] Tsuno, T. Ikeda, C. umata, K. Tomita, K. Konishi, M. Kawaguchi, H. J. Antibiot. 1986, 39, [3] Inaoka, T. chi, K. J. Bacteriology, 2007, 189 (1), [4] Inaoka, T. Satomura, T. Fujita, Y. chi, K. FEMS Microbiol. Lett. 2009, 291,

129 P-E-001 Synthesis of ew Ethyl Hydrogen Phosphonates and Inveαstigation of Their Biological Activities Ayşegül Hisar, Özdemir Doğan Middle East Technical University, Chemistry Department Aziridines can be found in the structure of biologically active natural compounds and they have very wide applications in organic chemistry. Aziridinyl phosphonates are the starting materials of α-amino phosphonates and used as enzyme inhibitors, haptens for catalytic antibodies, antibacterial agents, and herbicides. Although synthesis of aziridine-2-carboxylates has been the subject of many studies, a very limited research has been done for the synthesis of aziridinyl phosphates [1]. ur research group has developed a new method for the synthesis of aziridinyl phosphonates and studied their antibacterial activities [2]. In this study, the appropriate experimental conditions for the hydrolysis of phosphonates and biological activities of hydrolysed products, ethyl hydrogen aziridinyl phosphonates, have been investigated. Biological activity of newly obtained compounds are compared with their aziridinyl phosphate derivatives. Hydrolysis reactions are carried out in basic medium becauce in acidic medium aziridine ring opens. The crude product obtained from hydrolysis reaction was purified and acidified just by passing through the acidic form of Dowex resin. 1 H MR anaylsis showed that only one ester group of the phosphonate unit was hydrolyzed. At this conference, details of the hydrolysis conditions and biological activity results of hydrolyzed compounds will be presented. REFERECES [1] Kim, D. Y.; Rhie, D. Y. Tetrahedron 53, 13603, [2] Dogan, Ö.; Babiz, H.; Gözen, A. G.; Budak, S. European Journal of Medicinal Chemistry, 46, 2485,

131 P-E-002 Anion Extraction Using Poly (styrene)s Containing Pendant Calix[4]pyrroles Abdullah Aydogan İTÜ Faculty of Science and Letters, Department of Chemistry, Maslak 34469, Istanbul Calixpyrroles are the macrocycles having four pyrrole units connected to each other via sp3 hybridized carbon atoms. The first calixpyrrole was synthesized by Baeyer in 1886 via an acid c atalyzed condensation of pyrrole and acetone[1]. After the discovery of their anion binding ability they have found wide utilization in recognition, sensing, separation and sensing of anions[2]. In this context, chromophore group containing, extended and strapped calix[4]pyrrole compounds have been synthesized and used in wide range of applications[3]. n the other hand, recognition and separation of specific anions from aqueous environments have been considered as one of the important environmental problem. ne of the solutions of this problem can be addressed to calix[4]pyrrole containing polymers[4]. These polymers can be a potential solution for the selective separation of specific anions from aqueous environments. In this study, linear styrene polymers containing calix[4]pyrroles in different ratios have been used in the extraction of anions from aqueous solutions. Extraction studies have been carried out by subjection of aqueous solutions of Azure A dye to methylene chloride solutions of calix[4]pyrrole containing polystyrenes. Subjection of the aliquots of these experiments to UV-Vis analysis revealed that polystyrenes containing 10% pendant calix[4]pyrrole can extract the dye 75% more efficient than octamethylcalix[4 ]pyrrole. Similarly, these polymers were found to be effective in the extraction of tetrabutylammonium salts of fluoride and chloride from their aqueous solutions as have been proved by MR spectroscopy. REFERECES [1] Baeyer, A. Chemische Berichte, 5, 1094, [2] Gale, P. A.; Sessler, J. L.; Kral, V.; Lynch, V. Journal of the American Cemical Society, 118, , [3] ielsen, K. A.; Cho, W.-S.; Jeppesen, J..; Lynch, V. M.; Becher, J.; Sessler, J. L. Journal of the American Cemical Society, 126, , [4] Aydogan, A., Coady, DJ., Kim, SK., Akar,A., Bielawski, CW., Marquez, M., Sessler, JL. Angewandte Chemie- International Edition, 47, , [5] Aydoğan, A. IUPAC 9 th International Conference on Advanced Polymers via Macromolecular Engineering - Abstract Book, P-167,

133 P-E-003 Synthesis of Terminal Alkynes Containing a Ketal Group Abdullah Karanfil 1, Erdem Altun 1, Mustafa Eskici 1 1 Celal Bayar University, Faculty of Arts and Science, Department of Chemistry, MAISA The results obtained from the reactivity of cyclic sulfamidates towards acetylides [1] point out that the reaction of lithium acetylides 2 from terminal alkynes containing a ketal group 1 with chiral 1,2-cyclic sulfamidates 3 could provide an efficient route for asymmetric synthesis of 2,6-disubstituted piperidines 4 (Scheme 1). However, the terminal alkynes with a ketal group 1 can not be purchased, only synthesized in the laboratory. Thus the aim of this work is to synthesize terminal alkynes containing a ketal group 1. A brief survey of literature on the synthesis of terminal alkynes reveals that these compounds could be prepared by a number of ways. Terminal alkynes with a methyl 1a and a phenyl substituent 1b containing a ketal group were synthesized by modifications of various literature methods (Scheme 2) [2,3]. Alkynes with the methyl substituent 1a was prepared starting from 3-chloro-2-butanone using a ketalation, elimination, bromination and elimination reactions sequence. Alkynes with phenyl substituent 1b was synthesized starting from propiophenone using sequentially bromination, ketalation, elimination, bromination, elimination reaction. Synthesis of other alkyl substituent terminal alkynes containing a ketal group is ongoing. REFERECES [1] Eskici, M., Karanfil, A., Özer, M.S., Sarıkürkcü, C., Tetrahedron Letters, 52, , [2] Knowles, J.P., Whitting, A., European Journal of rganic Chemistry, , [3] Uemura, S., Fukuzawa, S-I., J. Chem. Soc. Perkin Trans. 1, ,

139 P-E-006 Calix[4]pyrrole Containing Polystyrene Beads Ahmet Akar, Abdullah Aydoğan ITU Faculty of Science and Letters, Department of Chemistry, Maslak 34469, Istanbul In this work, the production of calixpyrrole containing cross -linked polystyrene spheres and their use in the removal of anions from solutions have been studied. Similar copolymers have been synthesized and their anion binding properties have been investigated by us [1,2]. The microspheres have been obtained by suspension polymerization of styrene, calixpyrrole monomer and a cross-linker (5 and 10%) in the presence of AIB as initiator. The structural elucidation of attained microspheres has carried out using FTIR spectroscopy and these materials were tested in terms of anion removal properties both in organic and aqueous environments. According to anion removal experiments, these microspheres have been found to be able to bind anions both in organic and aqueous media and release the bound anions under appropriate conditions. Removal experiments of Azure A (a chloride counter anion containing dye) released that 5% cross -linker containing micro spheres removes 27% more dye compare to 10% cross -linker containing one. Both micro spheres containing 5 and 10% cross-linkers have been found to show almost equal anion removal percentages for tetrabutylammonium fluoride (%75) and chloride (%15 ). Main chain structure of the cross -linked polystyrenes has been demonstrated below. REFERECES [1] Aydogan, A.,Coady, DJ., Lynch, VM.,Akar,A., Marquez, M., Bielawski, CW., Sessler, JL.Chemical Communications,12, , 2008 [2] Aydogan, A., Coady, DJ., Kim, SK.,Akar,A., Bielawski, CW., Marquez, M.,Sessler, JL.Angewandte Chemie- International Edition,47, ,

141 P-E-007 Synthesis of xycodone in High Yield and Purity Ahmet Helvacı 1, İbrahim Bulduk 2, Fulya Taktak 3, 1 Afyon Kocatepe University, Faculty of Engineering, Department of Chemical Engineering 2 Uşak University, Faculty of Science and Literature, Department of Chemistry 3 Uşak University, Faculty of Engineering, Department of Chemical Engineering xycodone is a semi-synthetic, opioid receptor specific ligand with clear agonist properties. xycodone may produce any of a variety of effects including analgesia. Parenteral oxycodone was used mainly for the treatment of acute postoperative pain whereas combinations, for example oxycodone and acetaminophen, were used for moderate pain. xycodone is most commonly derived from thebaine, a minor alkaloid in the papaver somniferum poppy, and from thebaine analogues prepared from codeinone. 14- Hydroxycodeinone is the immediate precursor to oxycodone in these syntheses. In this study; Thebaine was dissolved in 85% formic acid. 30% Hydrogen peroxide was added. The mixture was stirred for four hours. Ammonium hydroxide solution was added to the mixture to increase the ph to 9. The solid precipitate was filtered and washed with water and ethanol. The solid was dried on the filter and in an oven. The 14-hydroxycodeinone was dissolved in water and 80% acetic acid. 10 wt % palladium on carbon catalyst was added and hydrogen was passed through the mixture for about 4 hours. The mixture was filtered to remove the catalyst. An ammonium hydroxide solution was added to the mixture up to ph 9. xycodone was precipitated and washed with water and with ethanol, and was dried. This process is useful for preparing oxycodone with low levels of.α,β-unsaturated ketones. xycodone was successfully produced in an easily practicable process, and the purity of the isolated compound was determined to be over 99.70% by HPLC analysis. The structure of oxycodone with high yield (90 %) was identified by 1 H MR, 13 C MR, FT-IR, elemental analysis and HRESIMS spectral data analysis. 98

155 P-E-014 Examination of the Antioxidant Activity for The Sunflower Plant Grown in Tekirdağ During the Harvesting Period Ayşe Afacan 1, Sevinç Adiloğlu 2, Canan Sağlam 3, Kudret Çetin 1, Ayşe İnal 1,Sinem Kınalı 1 1 amık Kemal Üniversitesi Murat Meslek Yüksekokulu Kimya Teknolojisi 2 amık Kemal Üniversitesi Ziraat Fakültesi Toprak Bilimi ve Bitki Besleme Bölümü 3 amık Kemal Üniversitesi Ziraat Fakültesi Tarla Bitkileri Bölümü In this study, the antioxidant activity of the sunflower plant grown in different regions in Tekirdağ was examined by taking into account soil, climate and regions. In the 21st century, a number of factors, such as developing technology, environmental pollution, the green house effect, Petro-chemical products, X-UV rays (photo-chemical) some drugs or medicine and smoking bring us to continually faced with a variety of substances that make up oxidative challenges. These effects show themselves in the formation of free radicals. Free radicals are the molecules that attack cells and immune system in human body. However, antioxidants are the molecules that prevent the destructive effects and chain reactions of free radicals, which can cause many diseases and early aging. Flavonoids, which have antioxidant characteristics, show the characteristics of free radical scavenger. In other words, oxygen reacts with antioxidants and they can be defined as substances which prevent adverse effects of foods. Contribution of the antioxidation is effective in delaying the oxidation of the fats and fat containing foods. Because the synthetic antioxidants such as BHA, BHT, and TBHQ are cheaper and more effective, they are used more commonly in food industry. Free radical scavenging activity of the sunflower plant during the harvesting period was determined using 1,1 biphenyl 2-pikriylhydrazyl (DPPH ). 2,3. Antioxidant activity was determined by β-carotene-linoleic acid system based on the measurement of conjugated diene hydro peroxides and volatile organic compounds resulting from the oxidation of linoleic acid. Keywords: antioxidant activity, Sunflower, harvesting, Tekirdağ. REFERECES: 1 Yıldız, L., Bazı Bitki Örneklerinde Antioksidan Kapasitesinin Spektrofotometrik Ve Kromatografik Tayini. İstanbul Üniversitesi Fen Bilimleri Enstitüsü Yüksek Lisans Tezi Cuendet, M., Hostettmann, K., Potterat,., _ridoid glucosides with free radical scavenging properties from Fagraea blumei. Helv Chim Acta, 80: Kirby, A. J., Schmidt, R. J., The antioxidant activity of Chinese herbs foreczema and of placebo herbs. J. of Ethnopharmacology 56: Dapkevicius, A., Venskutonis, R., Van Beek, T.A., Linssen, P.H., Antioxidant activity of extracts obtained by different isolation procedures from some aromatic herbs grown in Lithuania. J. of the Sci. of Food and Agr., 77,

157 P-E-015 Examination of the Antioxidant Activity for the Sunflower Plant Grown in Tekirdağ During the Physiological Period Ayşe Afacan 1,Sevinç Adiloğlu 2,Canan Sağlam 3,Ayşe İnal 1, Kudret Çetin 1,Sinem Kınalı 1 1 amık Kemal Üniversitesi Murat Meslek Yüksekokulu Kimya Teknolojisi 2 amık Kemal Üniversitesi Ziraat Fakültesi Toprak Bilimi ve Bitki Besleme Bölümü 3 amık Kemal Üniversitesi Ziraat Fakültesi Tarla Bitkileri Bölümü In this study, in the physiological period, the comparison of the antioxidant activities for the sunflower plant grown in different parts was carried out by taking into account the soil, the climate and the regions. In recent years, there is an increase in the studies regarding the antioxidant activity of phytochemicals. Due to the excessive amounts of highly reactive free radicals, many tissues, organs, and systems are damaged as a result of various metabolic reactions and one or more unpaired electrons in the body. Fort this reason, fruits and vegetables that contain antioxidant compounds, and the plants traditionally used for medical purposes reveals the importance of plants that are rich in antioxidant compounds for human health. In recent years, studies on plants and active substances extracted from these plants have increased. All in all, antioxidants are the molecules that can react with oxygen and they can be defined as substances which prevent adverse effects of foods. Contribution of the antioxidation is effective in delaying the oxidation of the fats and fat containing foods. Because the synthetic antioxidants such as BHA, BHT, and TBHQ are cheaper and more effective, they are used more commonly in food industry. In this research, free radical scavenging activity of the sunflower plant during the physiological period was determined using 1,1 diphenyl 2-pikriylhydrazyl (DPPH ). 2,3. Antioxidant activity was determined by β-carotene-linoleic acid system based on the measurement of conjugated diene hydro peroxides and volatile organic compounds resulting from the oxidation of linoleic acid. Keywords: Antioxidant activity, sunflower, Tekirdağ REFERECES 1 Yıldız, L., Bazı Bitki Örneklerinde Antioksidan Kapasitesinin Spektrofotometrik Ve Kromatografik Tayini. İstanbul Üniversitesi Fen Bilimleri Enstitüsü Yüksek Lisans Tezi Labuza, T. P. Kinetics of lipid oxidation in foods CRC Critical Review of Food Technology, 2, (1971) 3 Cuendet, M., Hostettmann, K., Potterat,., _ridoid glucosides with free radical scavenging properties from Fagraea blumei. Helv Chim Acta, 80: Kirby, A. J., Schmidt, R. J., The antioxidant activity of Chinese herbs foreczema and of placebo herbs. J. of Ethnopharmacology 56: Dapkevicius, A., Venskutonis, R., Van Beek, T.A., Linssen, P.H., Antioxidant activity of extracts obtained by different isolation procedures from some aromatic herbs grown in Lithuania. J. of the Sci. of Food and Agr., 77,

159 P-E-016 A ew Method for Synthesis of Isoindole Derivatives Ayse Tan 1, urhan H. Kishali 1, Yunus Kara 1 Atatürk University, Faculty of Sciences, Department of Chemistry, 25240, Erzurum In recent years, very few of the compounds synthesized for use in the treatment of malignant tumors showed biological activity. Moreover, some of these compounds have developed resistance against the tumor cells in time. For this reason, many researchers has worked synthesize compounds either overcome this resistance against the treatment of tumors or initiate tumor cell death when used alone. More recently, compounds of cantharidine and norcantharidine have been identified highly efficient biological activity and anticancer effects. In particular, studies on cantharidine and its demethylated derivative norcantharidine have supported these results. In addition, synthetically synthesized norcantharidine derivatives and - substituted derivatives of norcantharimide have reported to be a potential anticancer agent [1] Recently, new -substituted derivatives of norcantharimide have been carried out synthesis by our groups. Derivatives of α, β-unsaturated norcantharimide, compound 1, were examined addition reactions with secondary amine, for the synthesis of derivatives norcantharimide containing amine functional group in the cyclohexane ring together with oxygen. As a result, compound 3 was synthesized with secondary amine via 1,2-adduct to ketone 1 and compound 2 was not detected in the reaction via 1,4 -adduct. In the reaction was been obtained also dimeric structure 4 according to spectroscopic data. The result of this study, a new method was developed for the synthesis of aromatic amines. Substituted isoindole derivatives and new norcantharimide derivatives were synthesized with this new method. REFERECES [1] Lun-Huei, L., Hsu-Shan, H., Chiung-Chang, L., Lin-Wen, L., Pen-Yuan, LI, Chem. Pharm. Bull., 52, 855, 2004 [2] Tan, A., Koc, B., H., Kishali,., Sahin E., Kara,Y., Synthesis-Stuttgart, 7, ,

163 P-E-018 Bioactive Coumarins from Ferulago trojana, an Endemic Species to the Mountain Ida Begüm Çakar 1, Demet Dinçel 2, Mehmet Boğa 3, Gülaçtı Topçu 1,2 1 İstanbul Technical University, Faculty of Science and Letters, Department of Chemistry Maslak 34469, İstanbul,Turkey 2 Bezmialem Vakif University, Faculty of Pharmacy, Fatih 34093, İstanbul,Turkey 3 Batman University, Faculty of Science and Letters, Department of Chemistry, Batman 72100, Turkey The genus Ferulago belongs to one of the aromatic flowering plants families, Apiaceae (=Umbelliferae) which is widely distributed in the world by 49 species, and represented by 32 species in Turkey, 17 of which are endemic. In this study, we have investigated Ferulago trojana species, for its phytochemical constituents and biological activities, collected from the Mountain Ida, which has been introduced to the world of science for the first time in 2004 [1]. The main secondary metabolites of Ferulago species are coumarins, flavonoids and other phenolic compounds. Since ancient times, Ferulago species have been used as sedative, digestion facilitator, nerve stimulator and aphrodisiac [2]. Ferulago plants have been known as "çakşır otu among the people. In this study, dichloromethane and subsequently methanol extracts of plant were prepared, and consequently isolation of secondary metabolites were carried out by chromatographic methods (column chromatography, preparative TLC). The dichloromethane and methanol extracts of Ferulago trojana afforded 6 compounds. The structures of the isolated compounds were eluci dated by spectroscopic methods, namely 1D and 2D-MR, UV and Mass spectroscopy as bergapten, isoimperatorin, 3 -epidecursin, isomaltol, and isomaltol-3β--glucoside. In addition, structure elucidation studies on a coumarin is being continued. The antioxidant and anticholinesterase activities of the extracts and pure compounds were investigated. Isoimperatorin with furocoumarin skeleton has exhibited a high inhibitory activity of acetylcholinesterase (AChE) enzyme while other coumarins have showed moderate i nhibition against both AChE and butyrylcholinesterase (BChE) enzymes. ur studies are still going on to search potential of coumarins in the treatment of Alzheimer's Disease. CH 3 5'' 2' 3' '' 1'' 3'' 4'' ' Bergapten Isoimperatorin 2' REFERECES [1] Akalin E, Pimenov M, et al.; Ferulago trojana (Umbelliferae), a new species from western Turkey, Botanical Journal of the Linnean Society, 146, ; [2] Erdemoglu, Akalin E, Akgoc M, et al.; Comparision of the Seed ils of Ferulago trachycarpa Boiss. Different Localities with Respect to Fatty Acids, Martinus ijhoff Publishers Rec. at. Prod. 2:1, 13-18;

165 P-E-019 The Synthesis of Some ovel 5-Benzylthio-1-Substitue Tetrazole and Investigation of Their Structures Burak Bay 1, Ali Dişli 1 1 Gazi Üniversitesi Fen Fakültesi Kimya Anabilimdalı The porpose of this study is the synthesis of new alkyl and aryl thio tetrazole derivatives which probably shows high biological activity. The next part of this study, we try to syntesis new alkyl and aryl seleno tetrazole derivatives and we will investigate biological activity of all of this compounds. Tetrazoles are aromatic compounds which has four nitrogen atoms and one carbon atom. They are a unique compounds with very interesting features. This Compounds has a wide application area like using in pharmacology, the coordination chemistry of synthetic building blocks, a high nitrogen content in the composition of explosive materials, including energy materials etc. 5-Alkyl thio tetrazoles (especially 5- ethylthio tetrazole) are powerful activators for the synthesis of DA and RA. The presence of alkylthio tetrazoles groups does tetrazole cyclic more acidic than 5-alkyl tetrazoles. This increase develops the ability of tetrazole s activating. Also this tetrazoles use in photograph industry as a fotosentitive metarials and gas composition of airbags[1]. According to 1,5-disubstitued tetrazoles, 5-thiotetrazole derivatives has more than application. The cephalosporin class beta-lactam antibiotics are the best known example of the drugs which includes 1-substitued-5-thiotetrazole structures. Latamoxef which is a beta lactam antibiotic includes 1-substitued-5-thiotetrazole structure [2]. This study consist of three phases. Firstly, benzyl chloride compound reacts with KSC in methanol and benzyl thiocyanide compound is obtained. Second the benzyl thiocyanide is converted to tetrazole compound, using triethyl ammonium chloride and sodium azide in toluen with reflux and applied the necessary purification methods. And the last stage we made alkyl tetrazoles using K 2C 3 and alkyl halides in DMF. As a result we hope that the tetrazole compounds which we synthesized has similar activity as the synthesized tetrazoles which shows high biological activity before. REFERECES [1] LeBlance, W., Jursic, B., Preparation of 5-Alkylthio and 5-Arylthio tetrazoles from thiocyanetes using phase transfer catalysis. Synthetic Communications, 28:19, (1998) [2] Powers R. A., Shoicet, B. K., Structure-based approch for binding site identification on AmpC ß-lactamase J. Med. Chem., 45: , (2002) 122

169 P-E-021 The Influence of Structural Segments on Mesogenity of Chiral Calamitic Liquid Crystals Burcu Karaağaç 1, Hale cak 1, Belkız Bilgin Eran 1 1 Yildiz Technical University, Faculty of Arts and Sciences, Department of Chemistry, TR-34210, Istanbul Chiral liquid crystals are only a few of organic materials which have a wide application area for using in electronic devices. Most of chiral liquid crystal systems are liquid crystals with calamitic molecular geometry. These calamitic mesogens are usually composed of a central unit (a rigid core) which has two or more central ring systems and flexible units which alkyl or alkoxy chains are located at terminal positions. Terminal units can be a chiral chain or a polar group. The presence of linking units which increase the flexibility and length of molecule at central unit provides a convenient geometry for the emergence of mesophase. The minor modifications in the structural segments of mesogens can lead to drastic changes in their mesomorphic properties [1]. The interests on the design of novel liquid crystal molecules which can give a response to desired properties for useful application provide considerable supports for the explanation of fundamental principles between structure-mesogenity in these systems. The three main factors on the self-organization of molecules in LC systems are the molecular shape, microsegregation effects and chirality. In classical LC systems the shape of rigid units plays a dominating role for the organization of the molecules. Molecular chirality gives rise to helical superstructures which are in competition with the organization provided by the molecular shape. Segregation is the fundamental driving force of the self-association of similar segments in molecular structure. The phase behavior of liquid crystal material is replaced to have smectic organization (lamellar) due to the fact that fluorinated alkyl chains or siloxane units which are incorporated into molecular structure lead to phase segregation [2]. In this study, which aims the investigation of the effect of structural variations on mesogenity, the synthesis and characterization of the novel calamitic mesogens with chiral terminal units contain biphenyl benzoate unit have been carried out. The direction of linking units and type of terminal chains (olefine chain, hydroxyl terminated chain and siloxane unit) in molecular structure have been changed systematically and their effects on liquid crystal behavior have been discussed. The structures of new chiral calamitic mesogens have been characterized by the using classical spectroscopic methods ( 1 H-MR, 13 C-MR, 29 Si-MR and MS) and elemental analysis (EA ). The mesomorphic properties of the new compounds have been investigated by the using polarization microscope, differential scanning calorimetry (DSC) and electro-optic methods. The all synthesized compounds are enantiotropic liquid crystals. Additionally, they exhibit chiral mesophases in a wide temperature range. It is observed that the direction of linking unit and type of terminal chain lead to drastic changes on REFERCES [1] Hudson, S.A., Maitlis, P. M., Chem. Rev., 93, [2] Cheng, X., Das, M. K., Baumeister, U., Diele, S., Tschierske, C. J. Am. Chem. Soc., 126, , Bu çalışma, Yıldız Teknik Üniversitesi Bilimsel Araştırma Projeleri Koordinatörlüğü nün YULAP06 numaralı projesi ile desteklenmiştir. 126

185 P-E-029 The Synthesis of -substituted Pyrrole Derivatives in Water Dilek Akbaşlar, nur Demirkol, E. Sultan Giray Çukurova University, The Faculty of Arts and Sciences, Chemistry Department, Adana, 01330, Turkey Pyrrole and its derivatives are the heterocyclic compounds which not only are found in structure of both some bioactive drugs and some natural compounds such as haem, chlorophyll, B12 vitamin; but also show some important pharmacological properties such as antibacterial, antiviral, antitumor etc. Because of these properties, the synthesis of pyrrole derivatives has an important role in heterocyclic chemistry a nd there is an increasing interest in synthesis of this kind of compounds. In Paal-Knorr reaction, 1,4-dicarbonyl compounds are converted to pyrroles in the presence of ammonia or primary amines. In the literatures, many catalysts have been used for this conversion such as montmorillonite KSF [1], microwave irradiation [2], Bi ( 3 ) 3.5H 2 [3], Sc (Tf ) 3 [4], layered zirconium phosphate and zirconium sulfophenyl phosphonate [5]. However, several of these methods require prolonged reactions times, use of volatile organic solvents and toxic metals [1]. In this study, -substituted pyrrole compounds were synthesized from hexan-2,5-dione and various primary amines in water without using any catalysts and any organic solvents in high yields. It is an important study in terms of the development of a simple, clean and environmentally friendly process for the synthesis of - substituted pyrrole compounds. The structure of these compounds were characterized by FT-IR, GC-MS, 1 HMR and 13 CMR techniques. REFERECES R: Aliphatic and aromatic alkyl groups [1] Banik, B. K., Samajdar, S., Banik, I., Simple synthesis of substituted pyrroles. J.rg.Chem, 69: , [2] Rao, H.S.P., Jothilingam, S., Scheeren, H.W., Microwave mediated facile one-pot synthesis of polyarylpyrroles from but-2-ene- and but-2-yne-1,4-diones. Tetrahedron, 60: , [3] Banik, K. B., Banik, I., Dasgupta, K. S., A straightforward highly efficient Paal - Knorr synthesis of pyrroles. Tetrahedron Letters, 46: , [4] Chen, J., Wu, H., Zhang, X., Su, W., An approach to the Paal -Knorr Synthesis catalyzed by Sc (Tf ) 3 under solvent-free conditions. Tetrahedron Letters, 47: , [5] Currini, M., Montanari, F., Margarita, R., Layered zirconium phosphate and phosphonate as heterogeneous catalyst in the preparation of pyrroles. Tetrahedron Letters, 44: ,

189 P-E-031 Bent-Core Liquid Crystals with Biphenyl Central Core Carrying Terminal Branched Chains Dilek Güzeller 1, Hale cak 1, Belkız Bilgin Eran 1 1 Yildiz Technical University, Faculty of Arts and Sciences, Department of Chemistry, TR-34210, Istanbul "Bent-core" or "banana-shaped" liquid crystals are a novel class of thermotropic liquid crystals which attract considerable interest in liquid crystal field due to their unusual polar and chiral properties. Due to their bent molecular structures, the rotation of bent-core molecules around their long molecular axis is restricted. As a result of this, the presence of novel mesophases which differ from known classical liquid crystal phase have been explored in bent-core molecules. Up to now, eight different bent-core mesophases have been described and have been studied for their molecular models [1,2]. The generation of a main potential for technological interests by bent-core or banana-shaped liquid crystals increases attention on liquid crystal field and leads to a rise in the studies including structure-mesogenityelectrooptic property relations. The molecular structure of bent-core mesogens enables the design and synthesis of novel molecules which have different mesophase properties by minor changes in structural segments. This results in structural variety, mesophase diversity and the exploration of desired physical properties for technological application [3]. In this study, the novel bent-core compounds with biphenyl central core carrying terminal branched chains have been synthesized. The effect of different branched chains of the synthesized compounds on mesomorphic properties has been investigated. Besides, the direction of linking units used as ester groups in the structure has been changed. The effect of these changes on liquid crystal properties has also been searched. The structures of obtained compounds have been characterized by the using spectroscopic methods ( 1 H-MR, 13 C-MR, MS) and elemental analysis (EA ). The mesomorphic properties of the new compounds have been investigated by the using polarization microscope and differential scanning calorimetry (DSC ). It is determined that the presence of terminal branched chain and change in the direction of linking group for the synthesized bent-core compounds with biphenyl central core have a considerable effect on the molecular arrangement. As a result of this, these modifications play an important role on the emergence of the mesophases and changes of transition temperatures. REFERECES [1] Martinez-Perdiguero, J., Etxebarria, J., Folcia, C. L., rtega, J., Gimeno,., ve Ros M. B., The American Physical Society, E 82, , [2] cak, H., Bilgin-Eran, B., Prehm, M., Schymura, S., Lagerwallbd J. P. F., ve Tschierske C., Soft Matter, 7, 8266, [3] Shanker, G., agaraj, M., Kocot, A., Vij, J. K., Prehm, M., ve Tschierske, C., Adv. Funct. Mater., 22, ,

191 P-E-032 Trifolium stellatum's Fatty Acid Content and Biological Activity Dumrul Gülen 1, Elif Çukurova 2,Temine Şabudak 2, Mine Aydın 1, Burcu Özcan 2, Burçak Demirbakan 2, Cansu Şanda 2 1 amik Kemal University, School of Health Sciences, 2 amik Kemal University Faculty of Science Department of Chemistry Some types of Trifolium (Fabaceae-Leguminosae) is of great importance to humans and animals. These plants have an important role in animal health and nutrition is [1], in some of Trifolium species such as T. repens, T. arvense, and T. pratense are used for the treatment of expectorant, rheumatism aches, against constipation [2]. In the literature, some types of antidiabetic [3], antioxidant, anti-inflammatory [4], enzyme inhibitory activity have been found. This study is investigated the contents of fatty acids of Trifolium stellatum grown in Thrace region by gas choromatography. Also, antifungal and antimicrobial activity of T. stellatum are presented for the first time in this study. The plant was collected in its flowering time (2008) from Corlu-Tekirdag, Turkey. Then, the air dried plant material was extracted with n-hexane and methanol using Soxhlet extraction method. The contents of fatty acids of T. stellatum were determined in the n-hexane extract by using Gas Chromatography method. The hexane extract of T. stellatum contained of palmitic (32.92%) acids, oleic acid (40.58%) and linoleic (11.05%) as the most abundant fatty acids in the result of analysis. Palmitic acid is the first synthesized fatty acid s in the formation of fatty acids (lipogenesis) in organisms and the longer chain fatty acids produced from it. leic acid is protective against cardiovascular diseases, regulating blood sugar and has a protective effect against cancer. The obtained results indicated that n-hexane extract of T. stellatum is a rich palmitic acid and oleic acid. However, the antifungal and antimicrobial activities of n-hexane and methanol extracts of T. stellatum were investigated for the first time in this study. In this study screened n-hexane and methanol extracts for their antimicrobial activity against Enterococcus faecalis, Bacillus subtilis, Klebsiella pneumoniae, Staphylococcus aureus, Escherichia coli and Pseudomonas auroginosa by usiing Micro dilution method. According to the result, methanol extract of T. Stellatum showed significant activity against Enterococcus faecalis (27.81mg/mL ), Bacillus subtilis (495mg/mL), Klebsiella pneumoniae (495mg/mL de ), Staphylococcus aureus (495mg/mL ), Escherichia coli (495mg/mL) and Pseudomonas auroginosa (222.5mg/mL). Also, the MIC (495 mg/l) of methanol extract showed the strongest anttifungal activity against Candida glabrata in the antifungal activity experiment. As a result of biological activity, the methanol extract of T. Stellatum were the most active than n-hexane extract of T. stellatum. Phytochemical studies of the plant continues. REFERECES [1] Foo L. Y., Lu Y., Molan A. L., Woodfield D. R., Mcabb W. C.,2000, Pytochemistry, 54, , [2] Baytop T., Türkiye de Bitkiler ile Tedavi, İstanbul Üniversitesi Yayınları, [3] Khaled M. M., Hashim A. H., Kazuhiro., Ryoji K., Pytochemistry, 53, , [4] Sabudak T., Öztürk M., Gören A. C., Kolak U., Topçu G., Fatty Acids and other Lipid Compo sitin of five Trifolium Species with Antioxidant Activity, Pharmaceutical Biology,47, ,

193 P-E-033 Silicon Tetrachloride- Mediated Asymmetric Aldol Addition Reaction Duygu Aksakal 1, Özdemir Doğan 1 1 Middle East Technical University, Department of Chemistry Aldol addition reaction is one of the important and most studied carbon-carbon bond formation reactions in organic chemistry. Recent studies focused on the catalytic version of this chemistry. Recently, different from the Mukaiyama-type aldol reactions, chiral lewis bases have been used as promoters. In the presence of SiCl 4, these reactions proceed through a cyclic transition state leading to anti aldol product as a major product with moderate-to-good diastereo and enantioselectivities. Phosphoramide derivatives, BIAP and its derivatives,,-dioxides and -oxides have been extensively used for this purpose[1-4]. Recently, our group has designed new phosphineoxy aziridinyl phosphanates (PAP) as organocatalysts. These organocatalysts were used for the asymmetric aldol addition reaction between cyclohexanone and different aldehydes in the presence of SiCl 4. Although the optimization studies are still continuing, the results so far showed that aldol product can be obtained in good yield and reasonable enantioselectivity. The synthesis of PAP organocatalysts and the details of organocatalytic aldol reaction will be presented at this conference. REFERECES [1] akajima M., Yokota T., Saito M. and Hashimoto S. Tetrahedron Letters, 45, 61 64, [2] Kotani, S.; Shimoda, Y.; Sugiura, M.; akajima, M. Tetrahedron Letters, 50, 4602, [3] Denmark S.; Stavenger R.; Wong K.; and Su X. J. Am. Chem. Soc. 121, , [4] Rossi S., Benaglia M., Genoni A, Benincori T., Celentano G. Tetrahedron 67, ,

195 P-E-034 Aroma Compounds of Various Edible Mushrooms Ebru Deveci 1, Ibrahim Kivrak 1, Gulsen Tel 1, Mehmet Emin Duru 1, Aziz Turkoglu 2, Mansur Harmandar 1 1 Mugla University Faculty of Science Department of Chemistry 2 Mugla University Faculty of Science Department of Biology Although mushrooms have low fat, they are a good source of vitamin, protein and mineral [1]. In addition to this nutritional value, mushrooms are preferred in our country as in many countries, because of their taste and aroma. The quality of mushrooms depends on their taste, aroma, texture, and color. Among them, aroma is the most critical. Flavors consist of terpene, octane, octene, benzaldehyde, sulphure compounds and their derivatives. [1]. The main volatile compounds are also known contributing to mushroom flavor comprises of eight-carbon compounds. Among them, the main role in producing the unique fungal aroma and flavor has to be ascribed to the eight-carbon alcohol 1-octen-3-ol. Its odour could be described as mushroom-like, musty or earthy and, together with its oxidation product 1-octen-3-one, is considered to be the major contributor to mushroom flavor in most species of edible mushrooms [3,4]. The subject of this study is Agaricus bisporus, Calvatia gigantea, Chroogomphus rutilus and Clathrus ruber, which are naturally grow in Anatolia. These species are known as edible mushrooms. Mushroo ms were cut into small part and their aroma were analyzed with HS-GC/MS. Headspeace-GC/MS is a fast, simple, and solvent-free method and aroma compounds can be analyzed qualitative and quantitative. H H 3-octanone 1-octen-3-ol Benzaldehyde As a result of this study, 3-octanone and 1-octene-3-ol were found as major aroma compounds in Agaricus bisporus, Chroogomphus rutilus and Clathrus ruber mushrooms. Benzaldehyde was identified as major compound in C. gigantea mushroom. REFERECES [1] Mattila, P., Konko, K., Eurola, M., Pihlava, J.-M., Astola, J., Vahteristo, L., Hietaniemi, V., Kumpulainen, J., Valtonen, M. ve Piironen, V. Journal of Agricultural and Food Chemistry, 49, , [2] Kalac, P. Food Chemistry, 113, 9-16, [3] Maga, J.A. Journal of Agricultural and Food Chemistry, 29, 4-7, [4] Maggi, F., Papa, F., Cristalli, G., Sagratini, G. ve Vittori, S. Food Chemistry, 123, ,

197 P-E-035 Investigation of the Changes in Antioxidant, Anticholinesterase and Urease Inhibition Activities of Armillaria mellea extracts Treated with Temperature Ebru Erol 1, Yunus Çetintaş 1, Mehmet Öztürk 1, Mehmet Emin Duru 1, Aziz Türkoğlu 2 1 Mugla University, Faculty of Science, Department of Chemistry 2 Mugla University, Faculty of Science, Department of Biyology Today, makrofungis are widely utilized in the fields of medicine, pharmaceutical, food and fermentation. These have attracted the attention of researchers in recent years due to their antimutagenic, antihipertansiyon, antiviral, antimicrobial, antimutagenic, anti-hipertansiyon, anti-inflammatory, anti-allergic features as well as being immunomodulating and antitumor agent. These are generally regarded as natural products and nutritional supplements and produced in a variety of formulations in the world[1]. While Complexes of lectins, polysaccharides, polysaccharide-peptides, polysaccharide-protein were isolated, antioxidant and immunomodulating substances, anti-cancer effects were detected in most of these substances [2]. Armillaria mellea is a poisonous member of tricholomatacae family and known as honey fungus.in this s tudy, Armillaria mellea was collected from Belgrade Forest in Istanbul and the antioxidant, anti-cholinesterase and urease inhibition activities of both raw and cooked forms were analyzed. In the study, the raw and cooked mushrooms were extracted with solvents which were hexane, acetone, methanol, and water, respectively. Total phenolic amount pirokatekole of the obtained extracts was determined to be equal to total flavonoit amount kersetine. Β-carotene color expansion antioxidant activity, removal of ABTS radical cation, removal of DPPH free radical, superoxide anion radical removal were determined through CUPRAC method and Chelate effect was determined through metal[3]. Anticholinesterase activity in vitro of all the extracts of A. mellea was determined spectrophotometrically by using Ellman method [4]. For Urease enzyme inhibitory activity, after extracts of different concentrations were treated with urease, urea was used as the substrate. Ammonia resulting from the reaction was spectroscopically determined. When the antioxidant values of the extracts obtained at different temperatures were evaluated, the cooked ones showed higher antioxidant activity than the raw ones. In contrast to this, total phenolic coumpounds were found to be higher in raw extracts. Highly different results were found in enzyme inhibition activities. Results were statistically significant (p <0.05 ). REFERECES [1] Zhang M, Cui SW, Chueng PC, Wang KQ. Anti-tumor polysaccharides from mushrooms: a review on their isolation process, structural characteristics and anti-tumor activity. Trends in Food Science and Technology 18, 4 19, [2] Zhang RH, Li XJ, Fadel JG. yster mushroom cultivation with rice and wheat straw. Bioresource Technology 82, , [3] Öztürk M, Duru ME, Kivrak Ş, Mercan-Doğan, Türkoglu A, Özler MA. In vitro antioxidant, anticholinesterase and antimicrobial activity studies on three Agaricus species with fatty acid compositions and iron contents: A comparative study on the three most edible mus hrooms. Food and Chemical Toxicology 49, , [4] Ellman GL, Courtney KD, Andres V, Featherstone RM. A new and rapid colorimetric determination of acetylcholinesterase activity. Biochemistry and Pharmacology and Behaivor 7, 88 95, [5] Weatherburn, M.W., Phenol-hypochlorite reaction for determination of ammonia. Analytical Chemistry 39, ,

201 P-E-037 Enantioselective Diethylzinc Addition to -Sulphonylimines Eda Çağlı, Özdemir Doğan Middle East Technical University, Department of Chemistry Design of new chiral ligands for asymmetric synthesis is important. The ligand should be economical and efficient in enantioselective transformations. For the synthesis of some natural products and biologically active compounds, optically active amines are used as important intermediates. For this reason, it is important to develop new catalyst system which can produce optically active amines in an economical and efficient way[1]. ur group developed FAM, PFAM, and PAP ligands and used successfully for the enantioselective synthesis of organic compounds. These chiral ligands can also serve as organocatalysts for the synthesis of organic compounds. In this study, these ligands were tested as chiral catalysts for enantioselective synthesis of amines. For this purpose, diethylzinc was added to -sulphonylimine synthesized from aromatic and aliphatic aldehydes in the presence of FAM and PFAM ligands. Although ligand screening and optimization studies are continuing, the results obtained so far showed that chiral amines can be obtained in good yields and good enantioselectivities. During these studies, we have developed an excellent method for the synthesis of starting -Sulphonylimines. At this conference, synthesis of -sulphonylimine, chiral ligands and details of asymmetric diethylzinc addition to imines to form chiral amines will be presented. REFERECES [1] Almansa, R., Guijarro, D., Yus M., Tetrahedron: Asymmetry, 18, ,

203 P-E-038 Immobilization of p-sulfonato-calix[4.6]arenes onto Magnetic anoparticles and Use Their in Lipase-catalyzed Enantioselective Reactions Enise Akoz, Tuba Aksoy, Mustafa Yılmaz Selcuk University Department of Chemistry, 42031, Konya, Turkey Calixarenes, cyclic oligomers of phenolic units linked through the ortho positions, are a fascinating class of macrocycles [1]. They provide a unique three dimensional structure with almost unlimited derivatization possibilities. ne of the most important features of these compounds is their diversity. Therefore, calixarenes find applications as anion/cation and molecule carriers, as stationary phase, as sensors, as chiral and achiral catalysts and as membrane and as enzyme-mimic [2]. According to literature research, Calix[4,6]arenes containing sulfo groups immobilized on silica based magnetic nanoparticles were used in lipase immobilization at appropriate conditions. The enantioselective hydrolysis reactions of some rasemic aromatic esters were carried out using the prepared these immobilized enzymes REFERECES [1] J. Vicence, V. Böhmer, Calixarenes: A Versatile Class of Macrocyclic Compounds Kluwer Academic: orwell, MA, [2] Yilmaz, M., Sirit A., Deligoz, H., Calixarene based materials for cations and anions in Sorption Processes and Pollution: Conventional and on-conventional Sorbents for Pollutant Removal from Wastewaters by Edited Badot, P-M., Crini, G., Universitaires de Franche-Comté, Besançon,

209 P-E-040 Synthesis of ew Diol,Epoksidiol and Tetrols in Temperate Conditions and the Search of Biological Activities of Molecules Which are Synthesised Esen Yıldız Bekfelavi 1, Özgür Yılmaz 1, Pınar Küce 2, ermin Simşek Kuş 1, Gökhan Coral 2 1 Mersin Univercity-Faculty of Science and Literature-Chemistry Department 2 Mersin Univercity-Faculty of Science and Literature-Biology Department Molecules which are furnished with rings and which are comprehended a lot of group of hydroxi (-H ) are called as cyclitols. Cyclitol has many biological activities and because of its effect of glucosidase inhibitor ve antibiotic which show important activity,their synthesis are too important. 1 Recent years,to analyse the relationship between biologic activitiy and the form of molecule,the synthesis of cyclitols which are natural and unnatural has become one of the important subject of chemists who focus on this research too much. 2-4 In our study,by the molecules which are called as the first and which can be made easily by addition reaction and molecules which are called as the second and the fourth and which are the keys for cyclitol synthesis of derivations are synthesised by the classical method of oxidation in temperate conditions and high efficiency. Furthmore, the biologocal activities of molecules which are synthesised are investigated. RIGIS [1] Gültekin, M. S. Çelik, M., Balci M. Cyclitols: Conduritols and Related Compounds, Current rganic Chemistry, 2004, 8, [2] Hudlicky T., Entwistle D. A., Pitzer K. K. and Thorpe A. J., Modern methods of monosaccharide synthesis from non-carbohydrate sources, Chem. Rev. 1996, 96, [3] Kiddle J. J., Chem. Rev. 1995, 95, Hudlicky T. and Cebulak M., Cyclitols and derivatives, VCH, ew York, [4] Billington D. C., The Inositol Phosphates-Chemical Synthesis and Biological Significance, VCH, Weinheim,

219 P-E-045 Metal Ion-Controlled Self-Assembly and Hydrogelation of Peptides and Investigation of Their Bionanostructures Gözde Eşan 1, Salih Özçubukçu 1 1 Middle East Technical University, Graduate School of atural and Applied Sciences, Department of Chemistry After their serendipitously discovery in 1993, hydrogel of self-assembling peptides are becoming an emerging field especially in last 10 years [1]. For their application in selective drug delivery, tissue engineering and biomedical applications, extensive research are being done by many research groups. A large variety of peptides with different physical and chemical properties can be acquired by using different amino acids. Through chemical peptide synthesis, utilizing unnatural synthetic amino acids beside 21 natural amino acids, divergent peptides can also be obtained easily. Due to the richness of peptide chemistry, hydrogel forming peptides are getting more attention year after year [2]. Application of these hydrogel forming peptides in biomedical materials and tissue engineering is a challenging topic which requires alternative structures to get better and easily applied systems. ne of the methods that are applied to get self-assembling peptides is using strongly beta-sheet forming amino acids in the sequence of peptides. These peptides having strong beta -sheet structure can undergo self-assembly and form nano fibers to get hydrogel as a macroscopic property under certain conditions [3]. For the application of hydrogel forming peptides, self-assembly should be stimulus responsive and preferably reversible process. Temperature, ph, enzymes, reducing agents, light, ionic strength, metal ions are some of the stimulus that can be used to control self-assembly of peptides. The target of this project is to get a metal ion controlled self-assembly and hydrogelation of peptides in order to use as a biomedical material. For this purpose, initially, a bipyridine amino acid derivative that can coordinate to a metal ion will be synthesized using coupling reaction. The synthesis of this particular bipyridine amino acid is not known in the literature. However, the method for the synthesis of similar compounds will be applied for its synthesis. After getting this amino acid, a peptide composed of this amino acid and other natural amino acids which can form strong beta -sheet structure will be synthesized using solid phase peptide synthesis. Including unnatural bipyridine amino acid in the middle of peptide sequence, there will be totally 17 amino acids in this peptide. Utilizing the geometry of bipyridine upon binding to a metal ion, a control in the self-assembly and hydrogelation of the peptide in the presence and absence of metal ion is the target of this project. With the unique design of this system, in the presence of the metal ion, hydrogel structure will be disrupted and this feature can be used as a selective drug delivery system. REFERECES [1] (a) Zhang, S., Holmes, T., Lockshin, C., Rich, A., Proc. atl. Acad. Sci. USA, 90, , (b) Petka, W. A., Harden, J. L., McGrath, K. P., Wirtz, D., Tirrell, D. A, Science, 281, , (c) Qu, Y., Payne, S. C., Apkarian, R. P., Conticello, V. P., J. Am. Chem. Soc. 122, , (d) icodemus, G. D., Bryant, S. J., Tissue Engineering Part B: Review, 14, , [2] (a) Löwik, D. W. P. M., Leunissen, E. H. P., van den Heuvel, M., Hansen, M. B., van Hest, J. C. M., Chem. Soc. Rev., 39, (b) Mart, R. J., sborne, R. D., Stevens, M. M., Ulijn, R. V., Soft Matter, 2, , [3] (a) Holmes, T. C., Trends Biotechnol., 20, 16-21, (2002). (b) Collier, J. H., Hu, B. H., Ruberti, J. W., Zhang, J.;, Shum, P., Thompson, D. H., Messersmith, P. B., J. Am. Chem. Soc., 123, ,

221 P-E-046 Synthesis of Photovoltaic Materials Based on the Benzothiadiazole Gözde Murat 1,Haluk Dinçalp 1 1 Celal Bayar University, Faculty of Arts and Science, Department of Chemistry, Muradiye, 45030, Manisa Photovoltaics are higher cost prices than that of other materials used for the clean energy sources. Although this is a disadvantage, nowadays it is caused to increase interest to this technology. Because photovoltaic materials are the only renewable energy converting system which are demanding the increasing energy needs. ne of the solution about the problem for the high cost of the photovoltaics is to use of organic material as a semiconductor. rganic photovoltaics are a stage of development. There are some main advantages of them such as low cost prices, very small amount of the raw material wasted and the desired size/form to produce. Low power conversion efficiency is the major disadvantage for photovoltaics. But, it is shown from the literature that there are some promising developments about it.[1] To achieve high-efficiency PV cells, low-band-gap conjugated materials with appropriate energy levels are required for efficient charge transfer.[2] The benzothiadiazole -based copolymers show good power conversion efficiencies (PCEs) in the range of %. Benzothiadiazole-based copolymers and small molecules are commonly used due to their much higher hole mobilities, good structural stabilities and broad absorption spectra.[2,3] In our research, we have synthesized compunds which is shown in the Figure. Benzothiadiazole units were improved by adding donor groups to the structure. These structures are believed to be an effective in PV technology. The structures of compounds have been characterized by MR and FT-IR. The absorption, emission and electrochemical properties of the compounds have been studied. S H2 H2 S S H3C CH3 C H3 CH3 H3C CH3 REFERECES [1] elson, J., rganic photovoltaic films, Current pinion in Solid State and Materials Science, 6, 87 95, [2] Kong, J.A., Lim, E., Lee, K.K., Lee, S., Kim, S.H., A benzothiadiazole -based oligothiophene for vacuumdeposited organic photovoltaic cells, Solar Energy Materials & Solar Cells, 94, , [3] Mikroyannidis, J.A., Suresh, P., Roy, M.S., Sharma, G.D., Triphenylamine-and benzothiadiazole-based dyes with multiple acceptors for application in dye-sensitized solar cells, Journal of Power Sources, 195, ,

223 P-E-047 Isolation of Terpenoids from S. kronenburgii and Investigation of Their Potential Antioxidant and Anticholinesterase Activity Gülaçtı Topçu 1,2, Hatice İmran Güngördü 2, Tuba Kuşman 1,2 1 Bezmialem Vakif University, Department of Pharmacognosy, Faculty of Pharmacy, İstanbul 34093, Turkey 2 İstanbul Technical University, Department of Chemistry, Faculty of Arts and Sciences, İstanbul 34469,Turkey In our country, sage known as Adaçayı belonging to the family Labiatae (= Lamiaceae) is one of the most important cultivated medicinal plants worldwidely. Due to the high essential oil content, Salvia species are accounted as aromatic plants. They are used as medicinal plants and spices besides their use in perfumery, cosmetics and drug industries. Since ancient times, Salvia species have been used as antiseptic, antibacterial, sedative and memory enhancer, and in treatment of some menopausal problems. Sage is also used as carminative, tonic, diuretic, and against cold and is consumed as tea among the people in Turkey [1]. With recent floristic and taxonomic studies, the number of Salvia species grown in Turkey reached to 95, half of them being endemic [2]. In the last 30 years, our group have worked on bioactive components of more than 60 Salvia species growing in Turkey [3]. Phytochemical studies have shown that, the genus Salvia is rich diterpenoids and triterpenoids besides flavonoids and other phenolic compounds [4]. ur group has isolated over 200 abietane diterpenoids and 40 triterpenoids from 60 Salvia species. In this study, Salvia kronenburgii which is a very rich of secondary metabolites, especially terpenoids, collected from Van and investigated for its chemical constituents. Methanol extract of the roots afforded more than 10 compounds which were isolated by column and thin layer chromatography. Structure determination of compounds was carried out by 1D-and 2D-MR and other spectroscopic techniques in detail. Structures of the isolated two diterpenes with abietane skeleton are given below, namely cryptanol (1) ve ferruginol (2). Determination of antioxidant and anticholinesterase activity of the obtained pure di - and triterpenoids will be carried out subsequently structure elucidation studies. 1 2 REFERECES [1] Baytop, T. Türkiye de Bitkilerle Tedavi (Geçmişte ve Bugün ), 2. Baskı, obel Tıp Kitabevi, İstanbul, [2] Davis, P.H., Flora of Turkey and the East Aegean Islands, 7, , University Press, Edinburgh,1982 [3] Ulubelen, A.,Topçu, G., Johansson, C.B. Journal of atural Products, 60, , 1997 [4] Topcu, G.,Türkmen Z., Schilling, J.K., Kingston, D.G.I. Journal of atural Products, 2004, 67,

225 P-E-048 Determination of Bioactive Components in Some Wood Mushrooms from Anatolia Gulsen Tel 1, Ebru Deveci 1, Mehmet Emin Duru 1, Aziz Türkoglu 2 1 Mugla University Faculty of Science Department of Chemistry 2 Mugla University Faculty of Science Department of Biology Mushrooms are described as useful in the prevention of diseases such as hypertension, hypercholesteremic and cancer [1]. owadays, mushrooms are widely used in medicine, pharmacy, food and fermentation fields. Because of mushrooms are immunomodulatory and antitumor agents as well as antiviral, antimicrobial, antimutagenic, antihipertansiyon, antiinflammatory, antiallergic and like these features, they are attracting the attention of researchers in recent years. They are often seen as natural products and nutritional supplements and they are also produced in various formulations around the world [2]. These characteristic properties of mushrooms are caused from their chemical composition [1]. H H H H H H H H H H H quercetin pyrocatechol ascorbic acid Ganoderma applanatum, Funalia trogii, Ganoderma lucidum, Fomes fomentarious wood mushrooms which are grown in Anatolia are the subjects of this study. Total phenolic, total flavanoid contents, vitamin C, β - carotene and lycopene amounts were determined for alcohol extracts of these mushrooms. Total phenolic and total flavanoid contents of mushrooms were determined as pyrocatechol and quercetin equivalents, respectively. The amounts of vitamin C in all mushrooms were determined as ascorbic acid equivalents. Amounts of β-carotene and lycopene were determined by spectrofotometrically. Among the mushrooms, G. lucidum contains the highest amount of total phenolic (98,67±0,32) and total flavonoid compounds (760,38±1,25), F. trogii mushroom has the highest amounts of vitamin C (5,82±0,14 mg/g) and lycopene (1,04±0,02mg/g ). While G. lucidum and F. fomentarious don t have β-carotene, it was determined that G. applanatum and F. trogii mushrooms contain 0,86±0,21 mg/g and 0,43±0,14 mg/g β-carotene, respectively. REFERECE [1] Ribeiro, B., Rangel, J., Valento, P., Baptista, P., Seabra, R. M. and Andrade, P. B. Journal of Agricultural and Food Chemistry, 54, , [2] Zhang, M., Cui, S.W., Chueng, P.C. and Wang, KQ. Trends in Food Science and Technology, 18, 4 19, [3] Moradali, M.F., Mostafavi, H., Ghods, S. and Hedjaroude, G.A. International Immunopharmacology, 7, ,

227 P-E-049 Determination of Vitamin C Concentration of Some Edible Mushrooms Gulsen Tel 1, Ebru Deveci 1, Mehmet Emin Duru 1, Mehmet zturk 1 1 Mugla University Faculty of Science Department of Chemistry In addition to the use of mushroom as foods contain very high amounts of vitamins A, C and β -carotene, have antioxidant activity for all of them, may have protective effects have been reported [1]. owadays, mushrooms are the most commonly used sources of food and new pharmaceutical products [2]. Because of vitamin C (ascorbic acid) has a strong reducing activity, it is a powerful antioxidant. It easily reacts with superoxide and hydroxyl radical, by this way it plays a role in their clearance. Also it helps to show of antioxidant properties and protect to structure of fat-soluble vitamin E. It isn t available in natural foods, but it can be added to some foods as an antioxidant [3,4]. It is reported that the antioxidant properties of vitamin C plays a role in the transformation of carcinogenic nitrates and reactive oxygen species and it reduces the possible risk of cancer by 75 % in literature [5]. Amonita ovoidea, Chroogomphus rutilus, Calvatia gigantea, Lyophyllum decastes, Pleurotus ostreotus, Tricholoma fracticum and Tricholoma imbricatum collected from Uşak are the subjects of this study. The amounts of vitamin C in all mushrooms were determined as ascorbic acid equivalents. According to obtained results, the highest amounts of vitamin C were found in C. rutilus (5.09±0.17 mg/g). Then the highest amounts of vitamin C were found Lyophyllum decastes (4.78±0.41 mg/g) and Tricholoma fracticum (4.33±0.06 mg/g) mushrooms, respectively. REFERECES [1] Murcia, M. A., Martinez-Tome, M., Jimenez, A. M., Vera, A. M., Honrubia, M., Parras, P. Journal Food Protection., 10, , [2] Tong, H., Xia,., Feng, K., Sun, G., Gao, X., Sun, L., Jiang, R., Tian, D. and Sun, X. Bioresource Technology, 100, , [3] Akkuş, I. Mimoza Yayınları, 1. Baskı, 62-68, [4] Granado, F., lmedilla, B., Gil-Martinez, E., Blanco, I., Millan, I., Rojas-Hidalgo, E. Clinical Science, 94, , [5] Keevil, J.G., sman, H.E., Reed, J.D., Folts, J.D. Computers & Chemicals, 130, 53-60,

239 P-E-055 Microwave-assisted Amination of Bromoanthracene and Phenanthrene Derivatives Hasan Saral 1, Özgür Özdamar 2, Yunus Bekdemir 3 1 ndokuz Mayıs University, Faculty of Science and Arts, Chemistry Department 2 ndokuz Mayıs University, Yesilyurt Demir Celik Vocational School, 3 Canik Basarı University Samsun, 55139, Turkey Amino group (-H 2) is commonly used building block in the synthetic organic chemistry, medicinal and agrochemical. Many kinds of biologically active molecules contain different types of amines. Among them, the aryl amines have particular importance, since it is one of the basic structure motifs in nature. Primary aryl amines are also used as a starting material for synthesis of molecular structures which are important in Fine Chemical applications. In addition, potential used as a ligand in various applications of the obtained structure increases the interest in the preparation of such structures lies in its [1]. Metal-catalyzed C- bond formation reactions are commonly used in industrial chemistry and academic studies. Copper-catalyzed C- bond formation reactions is a powerful tool for the preparation of nitrogencontaining compounds with high usage in synthetic, biological, pharmaceutical and material science. In recent years, the usage of iron salts for transition metal catalyzed C- bond formation has emerged as an alternative route. Iron salts are cheap and have low toxicity. Iron-catalyzed C- bond formation reactions provides an environmentally friendly catalytic method when compared with other transition metals [2]. In our study, Cu and Cu/Fe common catalyzed amination of 9-bromoanthracene, 9, 10-dibromoanthracene and 9-bromophenanthrene were carried out on microwave conditions. Compounds were purified by column chromatography and determined with spectroscopic methods. REFERECES [1] Thibault, M., E., Luska, K., L., Schlaf, M., Synthesis, 5, , 2007 [2] Correa, A., Manchero,., and Bolm, C., Chemical Society Reviews, 37,

241 P-E-056 Synthesis of Xanthenes Using 1,3 cyclohexadione and Aldehydes in Supercritical Ether Hasan Ulusal, E.Sultan Giray Çukurova Universty, Department of Chemistry, Adana owadays supercritical fluid is an importance for organic synthesis studies. In supercritical conditions solvents allow using as synthesis area owing to increasing solving power and decreasing viscosity that are connecting with temperature and pressure. But using of C 2 is limited because of inadequate solving power of C 2[1]. n the other hand, there are many studies in the subcritical and supercritical water. There are rare studies about organic synthesis studies in supercritical diethyl ether in articles. In this study, Xanthene derivatives 3 were synthesized using 1,3- cyclohexadione 1 and several aldehydes 2 in supercritical diethyl ether[2],[3]. This reaction takes min at 200 o C and atm. And there is no need any purification of yield. So, this study suits to green chemistry for synthesis of xanthenes which is a new method. REFERECES [1] alawade, S.P, Picchioni, F., Janssen, L.P.B.M., 31, 19-43, 2000 [2] Venkatesan,K., Pujari,S.S., Lahoti,R.J.,Srinivisan K.V, 15, , 2008 [3] Zhang, Z.H., Liu, Y.H, 9, ,

255 P-E-063 Synthesis of Codeine in High Yield and Purity İbrahim Bulduk 1, Fulya Taktak 2, Ahmet Helvacı 3 1 Uşak University, Faculty of Science and Literature, Department of Chemistry 2 Uşak University, Faculty of Engineering, Department of Chemical Engineering 3 Afyon Kocatepe University, Faculty of Engineering, Department of Chemical Engineering Codeine is widely used as an analgesic and antitussive and is the methyl ether of morphine. It has been prepared synthetically by methylation of the phenolic hydroxyl group in morphine. Thus, it is known to prepare codeine by the reaction of morphine with a methylating agent in the presence of a base. In this study; morphine was suspended in toluene. The toluene suspension was stirred mechanically and dried azeotropically at C for 1 hour. The suspension was cooled to C. Phenyltrimethylammonium chloride and potassium hydrogen carbonate were charged. The contents of the flask were stirred mechanically and the suspension was refluxed between C for 10 hours. The reaction mixture was cooled to room temperature. The reaction mixture was extracted with solution of sodium hydroxide (2 times) to remove unreacted morphine. Activated carbon was charged into reaction mixture and the contents were stirred mechanically at room temperature. The black suspension was filtered using a glass funnel over a bed of diatomaceous earth. Filtrate was diluted with ethanol. A solution of phosphoric acid in ethanol was added dropwise while stirring. A white precipitate was formed and filtered. The filter cake was washed with ethanol. The isolated codeine phophate was purified by crystallization using an alcohol/water mixture. If desired, the codeine salt may be converted to its free base. It is believed that the basicity of the reaction medium under the mentioned reaction conditions is i deal for the formation of the desired product but not the dimethylated impurity. While stronger bases lead to small amounts of methylcodeine, weaker bases do not lead to complete conversion of morphine to codeine. The capability to direct the reaction so that methylcodeine is not formed is a major contributor to the efficiency of the process, which is reflected in the high yield and purity of the product. 212

257 P-E-064 Synthesis and Characterization of Some ovel β-ketoester Compounds Containing Thiazole Ring İrfan Koca 1, Mehmet Gümüş 1, Ali Dişli 2 1 Bozok Uni., Faculty of Arts and Sciences, Department of Chemistry, Yozgat, TURKEY 2 Gazi Uni., Faculty of Sciences, Department of Chemistry Teknikokullar Ankara, TURKEY Thiazole that five membered heterocyclic aromatic compound contains and S atoms at 1 and 3 positions. Altough there is thiazole in nature itself, thiazole ring are found in natural products such as cyclopeptides and peptide alkoloids [1]. Certain chemicals obtaining through synthesis which are used in the active ingredient of many drugs, dyes and industry contains thiazole ring as well as biologically active natural compounds such as Thiamine (vitamin B1) and penicillin. Also red rhodanine dyes and yellow primulin dye are among the thiazole compounds. Sulfathiazole, sulfasüksidin and promisol containing thiazole ring are synthetic active pharmaceutical ingredients. These products have significant antimicrobial and antifungal properties. In addition, natural thiazole products isolated from seafood.shows antineoplastic and cytotoxic activity. Mertax which is used vulcanization of rubber is a thiazole derivative [1,2]. β-ketoester compounds, using as the starting compound for the synthesis of many organic compounds is important in organic chemistry. Generally β-ketoesters can be obtained with ethylacetate and a carbonyl compound containing α-h in the presence of a strong base by Claisen condensation reaction [3]. Scheme 1. Synthesis reactions of β-ketoester compounds containing thiazole ring In this study, β-ketoester compounds containing thiazole ring which will be used in the synthesis of several heterocyclic compounds.were synthesized from thiourea derivative compounds. Characterization of synthesized compounds was performed using molecular spectroscopic methods. REFERECES [1] Kikelj D., Urleb U. Science of Synthesis; 11, , [2] Siddiqui., Arya S. K., Ahsan W. Azad B. International Journal of Drug Development & Research, 3, 55-67, [3] Benetti S., Chemical Review; 95, ,

265 P-E-068 Synthesis of ew Photochromic Derivatives of 2,3-bis (phenylthiazolyl )benz[f]indenone and Investigation of Their Photochromic Properties Mahmut Kose 1, Ersin rhan 2, Kazushi Suzuki 4, Ahmet Tutar 3, Cihansel Sancak Unlu 3 Ve Yasushi Yokoyama 4 1 Department of Chemistry, Faculty of Arts and Science, Bulent Ecevit University, 67100, Zonguldak, Turkey, E- mail: 2 Department of Chemistry, Faculty of Arts and Science, Düzce University, 81620, Düzce, Turkey, 3 Department of Chemistry, Faculty of Arts and Science, Sakarya University, Sakarya, Turkey 4 Department of Advanced Materials Chemistry, Graduate School of Engineering, Yokohama ational University, Hodogaya, Yokohama, , Japan Photochromism is defined as a reversible color change of a single chemical species between two forms (like A and B ). Photochromic compounds are classified into several groups according to their photoreactions. The most studied photochromic series are fulgides [1] and diarylethenes [2]. Among them diarylethenes are regarded as the best candidate for many possible industrial applications because of both thermal stabilities and fatigue resistance. In this work, syntheses of novel diarylethene type photochromic compounds were aimed. In this presentation, synthesize of new photochromic bisarylbenz[f]indenone derivative 2 and its detailed photochromic properties will be discussed. 2,3-bis (phenylthiazolyl )benz[f]indenone 1, were synthesized from the Suzuki coupling reaction of 2,3-dibromobenz[f]indenone and 5-methyl-2-phenylthiazol-4-ylboronic acid. And then the carbonyl group of 2,3-bis (phenylthiazolyl) benz[f]indenone 1 was reacted with MeLi to give a photochromic compound 2 in a high (90%) yield. Synthesis of 2 and its photoreactions are shown in Figure 1. Ph S Me Me 313 nm MeLi / THF, H H -78 o C 514 nm Me Me Ph Ph Me Ph Me S S Me S Ph S Me S Ph 1 2 2C Figure 1 The conversion ratio from 2 to 2C at the pss of 313-nm light irradiation was determined by HPLC and was found to be 98.4%. The HPLC chromatogram of the colored form at the pss showed two main diastereomers and the diastereomeric excess (de) was found to be 38%. As a result, compound 1, which exhibited weak photochromic properties, was converted its methylated derivative to give 2. The 2 displayed good photochromism. Detailed photochromic properties of 2 were investigated. 1 The authors are grateful to Bulent Ecevit University (Grant o.: BAP ), and TUBITAK (Scientific and Technical Research Council of Turkey) for the financial support of part of this work (Grant o.: 209T117). 3 The authors are indebted to the Department of Chemistry at Sakarya University and to The Scientific and Technical Research Council of Turkey (TUBITAK) for financial support (Grant-104T397). C. S. U thanks TUBITAK for fellowships. REFERECES [1] Yokoyama, Y., Chemical Reviews, 100, , [2] Irie, M., Chemical Reviews, 100, ,

273 P-E-072 Aza-Ene Reactions of Triazolinedione Melek Gul 1, Yiannis Elemes 2 1 Chemistry, Science, Amasya University Amasya/Turkey 2 Chemistry, Science, Ioannina University Ioannina/Greece The ene synthesis characterizes a σ-bond formation from the reaction between an ene companent and enophile so that 1,5-hydojen shift and migration of the double bond. The ene reaction provides a powerful method for C C, - or C- bond formation with concomitant activation of an allylic C H bond. We make use of ene reaction with ene triazolinedione, enophile -phenyltriazoline-3,5-dione (PTAD). We used the hetero-ene and hetero-enophile so that this reaction is named of aza -ene. -Phenyltriazoline-3,5-dione one of the most reactive electrophiles, reacts with conjugated dienes to give Diels -Alder products and with olefins to produce ene or [2+2] adducts. These reactions usually proceed in good yield with high regioselectivity and stereospecificity. We determined molecules structure with IR, MS, m.p., different MR methods and X -ray data. This results showed to ene reaction of -heterocycles with PTAD is stereospecific. REFERECES [1] A. Pastor, W. Adam, European Journal of rganic Chemistry, 2005, 14, [2] G. Vassilikogiannakis, Y. Elemes,, J. Am. Chem. Soc., 2000, 122 (39 ),

281 P-E-076 Synthesis of Derivatives Siyanosiklookten ejat Arçelik 1, M. Fatih Polat 2, Yakup Güneş 3 Ramazan Altundaş 1 Atatürk Üniversitesi Fen Fakültesi rganik Kimya Anabilim Dalı 2 Erzincan Üniversitesi Fen-Edebiyat Fakültesi rganik Kimya Anabilim Dalı 3 Atatürk Ünivesitesi KKEF Kimya Eğitimi Anabilim Dalı Cyclooctane is a medium sized ring which produces problems when its synthesis is attempted. Recent studies in the last few years show that through the use of the Grubss catalyzer, medium sized rings can be successfully synthesized. However, it is not possible to produce trisubstituted derivatives of cyclooctane with this method. Cyclooctane derivatives are found in the structures of many biologically acitve natural and synthetic compounds. ew methods with high product yields are needed for the synthesis of these compounds. In this study, the synthesis of cyanocyclooctene derivatives starting from cyclooctane will be discussed. SURCES [1] Tori, M. and Mizutani, R. Construction of Eight-Membered Carbocycles with Trisubstituted Double Bonds Using the Ring Closing Metathesis Reaction, Molecules, 15, ,

293 P-E-082 Synthesis of ew Fluorescent rganic Materials: Anthracene-Fluorene Hybrid ligomers urgül Akcebe, Barış Yücel İstanbul Teknik Üniversitesi, Fen Edb. Fakültesi, Kimya Bölümü The oligomeric structures, which synthesized with anthracene and fluorene derivatives by Suzuki crosscoupling reactions, were investigated according to the parameters such as flourescent properties, thermal and photo stabilities, and quantum yields. The reaction of benzocyclobutenedione with 2-bromo-7-lithiodialkylfluorene derivatives gave the alcohol intermediates that were heated in p-xylene at reflux open to the air to oxidate indenoanthraquinone derivatives. Then, indenoanthraquinone derivatives were reacted with alkynllithium and fluorenyllithium derivatives at -78 C and indenoanthracene derivatives were synthesized by this way. At final step, the brominated indenoanthracene derivatives were reacted with alkylated 2 - bromofluorene and alkylated 2,7-dibromofluorene units by Suzuki cross-coupling reaction and was taken four different oligomeric structures which were soluble in organic solvents and had highly fluorescence properties. It was used many different reaction conditions for having optimum results, and results showed us that was achieved. Acene and fluorene based materials have been commonly used on optoelectronic technologies since 1950s. The main reasons, which prefer these materials to silicon based ones, are easy application on small areas, high flexibility, low weight, and that can become soluble in organic and inorganic solvents by using some different methods. In this work, there was a new structural unit formed by participation of a phenyl ring with both chromophoric units (acene and fluorene) and this hybrid unit displays intrinsic properties of parent chromophores in a one form. By this way, it was aimed that the proposed acene -fluorene hybrid oligomers were exhibit enhanced fluorescence properties. Additionally, solubility problem was overcomed by the alkyl chains that were bonded to main sceleton of molecules. Bu Bu Bu Bu Bu Bu Bu Bu Bu Bu Bu Bu Fluoren-antrasen hibrit oligomer Bu Bu REFERECES [1] a) Carbon-Rich Compounds: From Molecules to Materials; Haley, M. M.; Tykwinski, R. R., Eds.; Wiley-VCH Verlag: Weinheim, b) Functional rganic Materials: Syntheses, Strategies and Applications; Müller, T. J. J.; Bunz, U. H. F, Eds.; Wiley-VCH Verlag: Weinheim, c) rganic Light Emitting Materials and Devices; Zhigang, L.; Meng, H., Eds.; Taylor & Francis: ew York, [2] Perri, S. T.; Foland, L. D.; Decker,. H. W.; Moore, H. W. J. rg. Chem. 1986, 51,

299 P-E-085 Solvent and Catalyst-free Mannich Reactions of Malonates and β-ketoesters nur Demirkol, Dilek Akbaşlar, E.Sultan Giray Çukurova University, The Faculty of Arts and Sciences, Chemistry Department, Adana, 01330, Turkey Multicomponent reactions (MCRs) are convergent reactions in which three or more reagents are combined to react in a one pot procedure.multicomponenr reactions constitute a major part in the present day organic synthesis with advantages ranging from lower reaction times, increased reaction rates to higher yields and reproducibility [1]. The three component Mannich reaction is one of the most important carbon -carbon bond forming reactions in organic synthesis and one of the most fundemental and convenient methods for preparation of β-amino carbonyl compounds, which are essential synthetic intermediates for many pharmaceuticals and natural products[2-6]. With the increasing interest in developing environmentally benign reactions, the atom economic catalytic processes or reactions without using any catalyst and solvent or the use of green solvents catalyst and solvent or the use of green solvents are ideal processes in organic chemistry. Pursuing our studies on the Mannich reaction of β-ketoesters, we wished to explore new conditions to make the synthesis simpler, to save energy and to prevent hazardous solvent waste and toxicity in Mannich reaction. Efficient coupling between β-ketoesters or malonates, different aldehydes and various primary amine derivatives were performed without using any solvent or catalyst. To the best of our knowledge this study is the first for Mannich reaction of β-ketoesters without using solvent and catalyst. The structure of Mannich products were characterized by FT-IR, 1 H-MR and 13 C-MR techniques. REFERECES [1] Weber, L., Illgen, K., Almstetter, M., Synlett, 3, 366, [2] Dömling, A., Ugi, I., Angew. Chem. Int. Ed. Engl., 39 (18), , [3] Arend, M., Westermann,. Risch, Angew. Chem., Int. Ed., 37, 1044, [4] Kobayashi, S., Ishitani, H., Chem. Rev., 99, 1069, [5] Mannich C., Krosche, W., Arch. Pharm., 250, 674, [6] Müller, R., Goesmann, H., Waldmann, H., Angew. Chem., Int. Ed., 38, ,

303 P-E-087 Researching of Cycloaddition Reactions of the Substitüed Bicyclic Dienophiles with Various Dien Systems Özgür Yılmaz, ermin Simşek Kuş Mersin Univercity-Faculty f Science and Literature-Chemistry Department, Mersin Cycloaddition reactions are used too much in organic synthesis reactions. The most important feature is forming of two pi ( ) bonds by opening of two sigma ( ) bonds between two elements. 1 The best known [4+2] cycloaddition reaction is Diels-Alder reaction. 2 Because of with Diels-Alder reactions, six carbons which area furnished with rings are made easily in one go, these reactions are very important in the means of mechanic and synthetic. 3,4 Furthermore, because cycloaddition reactions are regio- and sterospecific reactions, the molecules which are formed in the result of addition are usually molecules which are in the form of natural or which plays an important role in the production of natural products. 5 In our study, by being taken from dimethyl 7-oxo-bicyclo hepta-2,5-diene-2,3- dicarboxylate 1 as dienofil, they are put to the closed tubes and they are dissolved in 10 ml chloroform. 2,3 dimethyl -1,3-butadiene 2 as dien is added into the each tube and Diels-Alder reactions are investigated in the state of CH 3CH, H 3P 4, phenol, AlCl 3, -cyclodextrin, nafion-h catalysts and also Diels-Alder reactions are investigated without catalyst. After reactions, the first molecule that is synthesised with Diels-Alder reactions gives the third molecule 6 by the relationship between the second molecule and Diels -Alder reaction and also with the Retro-Diels Alder reaction, it gives the addition product of fourth and furthmore it is observed that the third and the fourth products are turned into the fifth molecule in related to catalyst in many efficiency. REFERECES [1] Woodward, R. B.;Hoffmann, R., Stereochemistry of ElectrocyclicReactions, J. Am. Chem. Soc., 87: 395, (1965). [2] Diels,., Alder, K., Syntheses in thehydroaromatic Series, LiebigsAnn.Chem., 460:98, (1928). [3] Butz, L. W. andrytina, A. W., rganicreactions 5 nd ed., Adams, R., ew York: Wiley, , (1949). [4] Hamer, J., 1,4-Cycloaddition Reactions: TheDiels-AlderReaction in HeterocyclicSynthesis, AcademicPress, ew York, (1967). [5] icolaou, K. C.; Snyder, S. A.; Montagnon, T.; Vassilikogiannakis, G. TheDiels Alderreaction in total synthesis, Angew. Chem.,Int. Ed., 41, , (2002). [6] Eberbach, W.; Argüelles, P.; M.; Achenbach, H.; Druckrey, E. andprinzbach, H., Helv. Chim. Acta, 54: 2579, (1971). 260

309 P-E-090 Adsorption of Amine Structured Surfactants on atural Zeolites Pelin Uzun 1, Y. Andelib Aydın 1, uran Deveci Aksoy 1 1 İstanbul Technical University, Chemical-Metallurgical Fac., Chemical Eng. Dep. Zeolites are inorganic materials having numerous advantages such as cheapness and easy accessibleness. Therefore, they have been utilized for removal of contaminants from drinking water, vegetable and animal oil, wine and other liquids. Modification of zeolites by changing their acidity and composition, improves their affinity to contaminants [1]. In this study; adsorption of surfactants, having amine based hydrophilic part, on a natural zeolite Bigadiç Clinoptilolite at different solvent media will be investigated. Three different primer amine based surfactants with 12, 16, 18 carbon will be used. Bigadiç clinoptilolite was sieved to μm particle size for usage in experimental studies. Total cation exchanged capacity and external cation exchange capacity was calculated by the method of Ming and Dixon [2]. The modification experiments were conducted batchwise by treating the clinoptilolite sample with surfactants in aqueous media, isopropyl alcohol or ethanol. The initial concentration of surfactant was ranged from M to 0.012M. To identify the effect of temperature on adsorption, the adsorption datas at 30 C and 60 C were compared. The amount of adsorbed surfactant on clinoptilolite (effective ion exchange capacity) was calculated by exploring the difference in the concentration of surfactant at initial condition and equilibrium. Determination of amine in the solutions were made by taking the ASTM D2074 (American Soceity for Testing and Materials) as basis [3]. Bigadiç clinoptilolite has cation exchange capacity and external cation exchange capacity meq/g, meq/g respectively. The maximum adsorption of surfactants was obtained when oleylamine (18 C) was used in aqueous solution at 60⁰C. At that condition, 85% percentage of cation exchange capacity was utilized to uptake amine in the solution. It was found that 0.004M initial concentration is enough and more concentrated samples did not show any significant result for improvement of the capacity. In conclusion, adsorption of surfactants onto the clinoptilolite leads to a cationic structure on the surface and provides an increase on adsorption of anionic compounds. The aim of this study is highly efficient removal of organic and inorganic, anionic contaminants in wastewater. REFERECES [1] Aleksandra D. V., Magdalena R. T., Aleksandra S. D. and Vera T. D. Applied Clay Science, 17, , [2] Ming, D. W., Dixon, J. B. Clays and Clay Minerals, 35, , [3] ASTM D2074, American Society for Testing and Materials, ,

313 P-E-092 Investigation of Diels-Alder Reactions in Subcritical Water Reşit Yıldız, Dilek Akbaşlar, E.Sultan Giray Department of Chemistry, Cukurova University, Adana, Turkey Studies in the early 1980s under the leadership of Breslow, when water is used instead of organic solvents are observed to increase the rate of Diels -Alder reactions [1]. However, a non-polar compounds under normal conditions is very low solubilitiy in the aqueous. Under normal conditions, the dielectric constant of water is about 80. The dielectric constant of water decreases supercritical and subcritical conditions. Thus, water can be transformed an excellent solvent for organic matter [2]. Korzenski et al. (1997) Diels-Alder reactions showed that can happen in subcritical or supercritical water [3]. In this study; increasing the water solubility of Diels -Alder products (endo) has been synthesized in subcritical water. This compounds have been characterized by using 1 H-MR, GC-MS and FT-IR. Thus,fast, efficient and clean endo-diels-alder compounds were obtained by the method of synthesis. REFERECES [1] Breslow, R., Rideout,D., J. Am. Chem. Soc.102,1897, [2] Ikushima, Y., Hatakeda, K., Sato,., Yokoyama, T., Arai, M., J. Am. Chem. Soc., 122, 1908, [3] Korzenskı, Mıchael B., Kolis, Joseph W., Tedrahedron Letters, ,

333 P-E-102 Preparation of Melt Derived 45S5 Bioactive Glass from Rice Hull Ash and its Characterization Sevil Yücel 1, Didem Özçimen 1, Pınar Terzioğlu 1,2, Serhat Acar 1, Can Yaman 1 1 Bioengineering Department, Faculty of Chemical and Metallurgical Engineering, Yildiz Technical University, Davutpasa Campus Esenler, Istanbul-Turkey 2 Chemistry Department, Faculty of Sciences, Muğla University, Kötekli Campus, Muğla-Turkey Bioactive glasses are inorganic bone regeneration materials which have been used for bone and cartilage reconstruction in orthopedics, oral, maxillofacial and otological surgery applications, especially based on mainly silicate or phosphate systems [1]. The bioactive glass can be prepared through sol-gel or melting method. Conventionally, commercial silica products such as tetraethylorthosilicate and tetramethylorthosilicate were used as silica sources [2]. Rice husk ash consists high grade (87-97%) of amorphous silica. The extraction of amorphous silica is simple and thus rice husk ash can be used as an alternative low cost silica precursor [3]. In the present study, the melting technique was applied to produce bioactive glasses with rice hull ash silica and commercial silica. In the present study, the use of rice hull ash silica and by comparing with commercial silica for synthesizing a 45S5 bioactive glass biomaterial with a simple and effective technique investigated. In order to determine the effect of simulated body fluid on the behavior of 45S5 bioactive glass the 7, 14, 21- day weight loss processes have been followed, SEM images were taken and Vickers hardness were determined. All results obtained from SEM, FTIR, XRD, Vickers hardness analysis and also degradation in tris solution showed that the rate of hydroxyapatite formation were observed for all bioglass samples. As a result, it can be said that because of the bioactivity of rice hull ash silica it can be used as an alternative to commercial silica for the production of the 45S5 bioglass. REFERECES [1] Gao, T, Aro, H.T., Ylanen, H. and Vuorio, E., Biomaterials, 22, , [2] ayak, J. P., Kumar, S. and Bera, J., Journal of on-crystalline Solids, 356, , [3] Kalapathy, U., Proctor, A. and Shultz, J. Bioresource Technology, 73, ,

335 P-E-103 Pharmacophore Modelling and 4D-QSAR Analysis of Ruthenium (II) Arene Complexes by Electron Conformational-Genetic Algorithm Method (EC-GA) Sevtap Çağlar 1, Semiha Aydın 1, Emin Sarıpınar 1 1 Erciyes University Faculty of Science Department of Chemistry rganometallic Ru (II) arene complexes (complexes containing metal -carbon bonds) offer much scope for the design of anticancer agents. Some complexes were active against colon, pancreatic, and lung cancer [1]. In this study,the electron conformational genetic algorithm (ECGA) method had been employed as a 4D- QSAR approach to reveal the pharmacophore (Pha) and to predict anticancer activity in the of Ruthenium (II) arene complexes derivatives. After quantum chemical calculations were made by using the HF 3-21 G * method (aqueous medium ), the electron Conformational Compliance matrices (ECMC) [2] were prepared by means of the charge, bond order, the Cartesian coordinates conformational analysis information for all conformers of compounds in the series. ECMC s are compared within a certain tolerance values by using the program EMRE and responsible pharmacophore group for ruthenium (II) arene complexes was found. For selecting of sub-parameter which has the most effect on activity in serial and calculation of t heoretical activity values non-linear least square method and genetic algorithm which was taken part in EMRE program was used. In addition, compounds are classified as the training and test set and accuracy of the models were made as cross-validation and the statistical. (Three-dimensional structure of a compound which is belong to ruthenium (II) arene complexes serial was shown. ) This project was financially supported by Research Fund of the Erciyes University (BAP, Project umber: FBY REFERECES [1] Habtemariam A., Melchart M., Fernández R., et al. Structure -Activity Relationships for Cytotoxic Ruthenium (II) Arene Complexes Containing,-,,- and,- Chelating Ligands, J. Med. Chem., 49, , [2] Sarıpınar, E., Geçen,., Sahin, K., Yanmaz, E. Pharmacophore Identification and Bioactivity Prediction for Triaminotriazine Derivatives by Electron Conformational-Genetic Algorithm QSAR Method, Eur. J. Med. Chem, 45, ,

337 P-E-104 Metal Catalyzed Synthesis of Pyrrolidines by Asymmetric Cascade 1,3-Dipolar Cycloaddition Reaction of Azomethine Ylides Seylan Ayan, Özdemir Doğan Middle East Technical University, Department of Chemistry In recent cascade reactions have been studied significiantly by different groups. This reaction provides complex molecules from very simple starting materials in a single step. For that reason, it is considered as atom economical reaction and green chemistry. Asymmetric version of this reaction is also being studies by organic groups for the synthesis of complex chiral compounds. In this respect, we have studied metal catalyzed cascade reaction of azomethine ylides with electron deficient dipolarophiles using chiral ligands with silver metal. As the chiral ligands amino alcohol based ferrocenyl aziridinyl methanol (FAM) and phosphorous based phosphino ferrocenyl aziridinyl methanol (PFAM) were used. These ligands have an advantage of being synthesized easily on a gram scale starting from acryloyl ferrocene. Moreover, the yellow color of ferrocene ease the purification by flash column chromatography. For the cascade reaction of azomethine ylides glycine methyl ester, aromatic aldehyde, dipolarophile, chiral ligand, and silver salt or silver nanoparticles were mixed in the same reaction flask to form pyrrolidine derivatives. Although the optimization studies are still continuing preliminary results showed taht pyrrolidine derivatives can be obtained in acceptable yields and enantioselectivities. At this conference synthesis of chiral ligands and the details of pyrrolidine synthesis by catalytic asymmetric cascade reaction will be presented. 294

341 P-E-106 ew Ligands and Their Application in rganic Chemistry Şebnem Sarışan, Esra Tunçel, Volkan Kumbaracı, aciye Talınlı Istanbul Technical University, Graduate School of Science, Department of Chemistry Aryl-14-H-dibenzo[aj]xanthene type compounds have the property of many biological activity. Therefore, these compounds are widely used in many fields, these fields could be classified as agriculture and industry in its own. Xanthenes constantly used in the agriculture as a bactericide. Benzoxanthenes also used in industries such as dyes in laser technology and fluorescent materials for visualization of biomolecules[1]. Structures of these compounds have resemblance to chiral phosphine ligands, and hence dibenzoxanthene is possible to use as a catalyst like phosphine ligands in the organic chemistry. In the present study, synthesis of phosphine and phosphate group containing dibenzoxanthene compounds have being aimed. For this purpose the first main compound naphthofuranofuran, 2,13-Dihydroxy-7a,14cdihydronaphto[1,2 :4,5]furo[3.2-d]furan, is synthesized by the reaction of 2,7-dihydroxynaphthalene and glyoxal bisulfite in slightly acidic environment. After that this compound is derived with dichloro phenyl phosphine or dicholorophenyl phosphine oxide for the synthesis of phosphorus group containing benzoxanthene ligand[2]. In conclusion, phosphine containing naftofuranofuran type containing ligands were synthesized. These compounds are used as catalysts in organic reactions and their enantioselectivity will be examined as a catalyst. REFERECES [1] Kamei. T, Iwasawa. T, Sato. H.A., Tetrahedron Letters, 52, , [2] Kızılcan., Akar.A, Talınlı., Yaşlak.S, Heterocylic Com., 5, o 1, 27-30,

343 P-E-107 Synthesis and Characterization of Triazine and Pyrazine Compounds From 2,3-Furandiones Şevket Hakan Üngören, Emine Dilekoğlu, İrfan Koca Bozok Uni., Faculty of Arts and Sciences, Department of Chemistry, Yozgat, TURKEY 1,2,4-triazines constitute an important group of pesticides which are used with broad application area. Many of them are used in order to increase the efficiency of crop plants in combating weeds. For instance, Metribuzin, which is an excellent selectivity pesticide, a commercial agricultural medicines. is produced by Bayer (Code o.: ) and Du Pont (Code umber: GPX-G2504 ). It have been introduced that Metribuzin affects photosynthesis of weeds during foliation with the study conducted in 1968 [1]. Later, these pesticides interact with chloroplasts in plants and the plant react this interaction by means of excessive secretion of certain enzymes and so that the plant cell wall damaged and death of the plant have been reported [1]. The other pesticides which are show similar biological mechanism with the structure of 1,2,4-thiazine-6-one structure are isomethiozin, ethiozin, metamitron, amibuzin [1-6]. Feature of herbicide of a series dicyano pyrazine have been reported by akamura and his working group and have been patented as agricultural fungicide by Hodogaya company [7]. Scheme 1. Synthesis Reactins of triazine and 2,3-dicyano pyrazine In this study, triazine and dicyano pyrazine compounds were synthesized from the reaction of active 2,3- furandiones with S-methyl carbazite and 2,3-diaminomaleonitrile, respectively. The subsequent reactions of resulting dicyano pyrazine were carried out with hydrolysis. Characterization of synthesized compounds was performed using molecular spectroscopic methods. REFERECES [1] Monaco, T.J., Weller, S.C. and Ashton, F.M., Weed Science: Principles and Practices. Fourth Edition, John Wiley & Sons, inc., ISB , ew York/USA, 671p. [2] Guo, H.C., Liu, S.Z., Hou, X.T., Wang, M. Chinese Chemical Letters, 12, , [3] Francisco, J., Valentin, A., Díez-Caballero, R.B., Altuna, M.A.G., Analyst, 113, , [4] Pang, G.F., et al. Anal. Bioanal. Chem., 384, , [5] Liu, B., et al. J. Agric. Food Chem., 58, , [6] Fedtke, C., Schmidt, R.R., Weed Science, 36, , [7] Shirai, K., Hou, D., Fukunishi, K., Matsuoka, M., J. Heterocyclic Chem., 37, ,

345 P-E-108 A ew Method for the Synthesis of 5-Alkylidene and 5-Imino Substituted Rhodanine Derivatives Şevket Hakan Üngören, urgül Tı Bozok University, Department of Chemistry, YZGAT 2-Thioxo-1,3-thiazolidine-4-on, named rhodanine. According to literature, it was seen, all of the rhodanine derivatives possess a vide spectrum of bioactivity [1]. ovel methods for the rapid synthesis of structurally varied rhodanines remain desirable. While the Knoevenagel condensation is a most convenient method for the synthesis of 5-alkylidene rhodanines, there are the convenient methods for the preparation of 5-imino substituted rhodanines, but these methods were not generalized [2]. The present work, We are aimed the preparations of 5-alkylidene and 5-imino substituted rhodanines by means of a convenient method. The method includes reactions of 1,3-thiazolidine-4,5-diones with Wittig reagents. 1,3-thiazolidine-4,5-diones were synthesized according to litheratures, were reacted both alkylidene and imino phosphoranes. The reactions were runned on C 5= group as regio- and stereo-selectively (Scheme 1 ). R X R S (Ph)3P CR2 R X R S R R X R S (Ph)3P R R X R S R X:, S R: Aril, Açil Başlangıç bileşikleri R Scheme 1. Synthesis of rhodanin derivatives with Wittig reactions. After the purifications of synthesized compounds by column chromatography were characterized with spectroscopic methods. In conculsion, we have described a simple, rapid and catalyst free procedure for the synthesis of variously substituted rhodanines. In continuing our work, the synthesized rhodanines will be investigated for their bioactivity. REFERECES [1] Zhang, H., Zhou, Y., Zhang, T., Li, Y. and Zhu, D. Journal of Colloid and Interface Science, 264, , Shin, D., Lee, J., Hahn, H.G., Tetrahedron, 66, , [2] Wade J.J. J. rg. Chem., 44, ,

357 P-E-114 Synthesis and Characterization of ew Perylene Monoimides for the Dye Sensitized Solar Cells Uğurhan Ağırkaya 1, Haluk Dinçalp 1 1 Celal Bayar University, Faculty of Arts and Science, Department of Chemistry, Muradiye, 45030, Manisa Two of the most common and the best suitable perylene dyes among the perylene derivatives are the perylene monoimides and diimides. Perylene diimides and monoimides are known in literature with high thermal and photo-physical stabilities and high molar absorption coefficients. They have high electron mobility, strong electron acceptor, electron conducting material and liquid crystal phase properties. Furthermore, due to the high quantum yields which are close to 1, they are among the suitable materials which have promising specialties in LED or other opto-electronic devices in the future [1]. Perylene monoimides possess five aromatic rings that are in high conjugated construction. They make strong absorption in wavelength of the visible region of electromagnetic spectrum of nm. They give back almost all the absorbed light as fluorescence [2-4]. The aim of the work is to synthesize new molecular structures of perylene monoimides and their derivatives that we expect to reach high efficiency values in dye sensitized solar cell (DSSC ). It is thought that promising results for DSSC will be achieved by using perylene monoimide derivatives which contain different aromatic groups in bay positions. Absorption, emission and cyclic voltammetry experiments have been performed for the synthesized dyes. The structure analyses of compounds have been performed with the FT-IR and MR spectroscopy. Ar Br Ar REFERECES [1] Zafer, C., Kus, M., Turkmen, G., Dincalp, H., Demic, S., Kuban, B., Teoman, Y., Icli, S., Sol. Energy Mater.& Sol. Cells, 91, , [2] Chesterfield, R. J., McKeen, J. C., ewman, C. R., Ewbank, P. C., da Silva, D. A.,Bredas, J. L., Miller, L. L.,Mann, K. R.,Frisbie, C. D.,rganic Thin Film Transistors Based on -Alkyl PeryleneDiimides: Charge Transport Kinetics as a Function of Gate Voltage andtemperature, J. Phys. Chem.,108, , [3] Wurthner, F., Perylenebisimide dyes as versatile building blocks for functional supramoleculararchitectures Chem. Commun., , [4] Jones, B. A., Facchetti, A., Wasielewski, M. R., Marks, T. J., High Mobility Air-Stable n-type PeryleneDiimide Semiconductors. Insight Into Materials Design for Stability of n-type Charge Transport, J. Am. Chem. Soc., 129, ,

367 P-E-119 The Synthesis and Properties of Some ew Potential Ionophore Azocalix[4]arene Schiff Base Yeliz Koç 1, Özlem Özen Karakuş 1 ve Hasalettin Deligöz 1 1 Pamukkale University, Faculty of Science-Arts, The Department of Chemistry, 20017, Kınıklı DEİZLİ Calixarenes, which occupy an important position in supramolecular chemistry, are cyclic compounds that are derived as a result of the condensation reaction of p-tert-butylphenol and formaldehyde in basic environment. These structures have two active functional groups that are defined as lower rim (-H group) and upper rim (p- position ). While etheric and esteric groups can be joined through lower rim, calixarenes give electrophilic substitution reaction that the aromatic compounds give. Thus, a vast number of calix[n]arene derivatives that have various configurations can be synthesized [1]. The aim of this study is to synthesize some new Schiff Base azocalix[4]arene derivatives, to characterise on their structures and to measure the relationship of synthesized compounds with metals by analyzing the interactions of them with various metals. Raney i /hydrazine Ar C H H H EtAc/ MeH H H H H 2 2 H 2 H 2 HC CH Ar Ar Ar R' a 2 / HCl R ' H 2 2 Br R ' R ' H 3C CH 3 H 3C CH 3 CH 3 H H H HC Ar HC Ar In this study, primarily p-tert-butylcalix[4]arene have been synthesized with familiar methods in literature. After, the removal of tert-butyl groups of calix[4]arene, the derivatization has been made with p-nitro benzyl groups [2]. itro groups have been transformed into amine groups with this reduction reaction. Later, Schiff based azocalix[4]arenes have been synthesized with nitrification reaction with amine groups as Schiff Bases. The structures obtained have been tried to be characterized by spectroscopic methods. As a conclusion, the structures of the new compounds have tried to be characterized by using the results of spectroscopic analysis (IR, 1 H-MR ). In addition the relationships of compounds with metals have been analyzed through extraction studies with various metals. REFERECES [1] C.D. Gutsche, Calixarene Revised, Royal Society of Chemistry, Cambridge, [2] Hajipour, A., Habibi, S. and Ruoho A., Chinese Journal of Polymer Science, 28, ,

373 P-E-122 Solid-state Dye-sensitized Solar Cells Using Red and ear-ir Absorbing Bodipy Sensitizers Yiğit Altay 1, Safacan Kölemen 1, Yusuf Çakmak 2, Şule Erten-Ela 3,4, Johannes Brendel 4, Mukundan Thelakkat 4, ve Engin U. Akkaya 1,2 1 Department of Chemistry, Bilkent University, Ankara 06800, Turkey 2 UAM-Institute of Material Science and anotechnology, Bilkent University, Ankara 06800, Turkey 3 Solar Cell Institute, Ege University, İzmir 35100, Turkey 4 Macromolecular Chemistry I, Applied Functional Polymers, Bayreuth 95440, Germany Dye-sensitized solar cells (DSSC) are successful alternatives to more widely used traditional semiconductorbased designs. For use as redox mediator, I- and I2 (to generate iodide/triiodide redox couple) is typically dissolved in organic solvents. However, the use of solvents creates temperature stability problems, and because of the volatility of the solvents, sealing of the cell is crucial. Most of plastics are not compatible with organic solvents, and thus the use of liquid electrolytes effectively precludes integration into flexible structures. Also most widely used ruthenium dyes are expensive and their preparation includes lengthy purification steps. In order to bypass the limitations imposed by liquid electrolytes, one of the most common hole transport materials is spiro-metad. a) b ) Fig 1. a) Solar cell design used in this study, b) Sensitizers used in this study. In this work, our goal was to investigate the performance of rationally designed boron-dipyrrin sensitizers in connection with spiro-metad. For that purpose, in addition to previously reported sensitizer 1, two more boron-dipyrrin dyes are synthesized to clarify relative effects of various modifications on the efficiency. In the parent Bodipy and in other derivatives, theoretical calculations suggest that on excitation there is significant charge relocalization on the meso carbon. Sensitizers 1 and 2 take the advantage of this natural Bodipy tendency for charge relocalization onto meso-position, by placing electron-acceptor/anchor groups on that position. The sensitizer 3 has the anchor group on a different position, forcing electron flow to an alternate position which apparently reduces the efficiency of charge injection. The results show that the sensitizer 1 has the highest efficiency. nly beyond 800nm, sensitizer 2 has IPCE values higher than those of 1. For sensitizer 3, IPCE values are below 1% in the nm region. As expected, sensitizers have very low fluorescence emissions due to strong charge transfer characteristics of the diphenylaminophenyl substituent. What is also remarkable is the near flat response of these sensitizers in the visible wavelengths. Actually, the response is one that could be expected from a black dye. REFERECES [1] Erten-Ela, S.; Yilmaz, D.; Icli, B.; Dede, Y.; Icli, S.; Akkaya, E. U., Solid-State Dye-Sensitized Solar Cells Using Red and ear-ir Absorbing Bodipy Sensitizers, rg. Lett., 12 (17), ,

375 P-E-123 The Investigation of Antioxidant, Anticholinesterase and Urease Inhibition Activities of Extractcs of Tricholama terreum (Schaeff.: Fr ) Kumm. btained by Different Extarction Methods Yunus Çetintaş 1, Ebru Erol 1, Yusuf Sıcak 1, Mehmet Öztürk 1, Mehmet Emin Duru 1 Muğla University Faculty of Science Department of Chemistry, Istanbul, 48121, Turkey Mushrooms have been used for food or medicinal purposes since ancient times. Thus, edible mushrooms, has been the focus of especially Asian researchers, since two thousand years 1. It is reported that besides the food use of mushrooms, mushrooms have protective effects due to their high vitamin A,C, β-carotene content and showing antioxidant activity. owadays, the butyrylcholinesterase and acetylcholinesterase inhibition performing agents most widely used drugs in the treatment of diseases such as Alzhei mer. However, all over the world a variety of natural product activities have been investigated because of the side effects of these drugs. Inhibition of the urease enzyme is an important factor in human and animal health and also in the thrivement of so many of the pathogen that is harmful for agriculture 2. Therefore, today the studies based on the inhibition of urease activities, draws attention to prevent or treat diseases that occur primarily because of urease. Tricholoma terreum (Schaeff.: Fr ) Kumm. mushroom have been used in the present study reffered as Cincile, Milibarı, and Kurakız mushroom among people. These are emerging in calcareous soils in clusters, especially in September, ctober and May. The mushrooms firstly divided into two parts which are edible and has commercial potential. Some of them were cooked and the other part was freshly investigated. Three different extraction method was applied to cooked and raw mushroom samples (extraction at room temperature, extraction with Soxhlet extraction and ultrasonic bath) and 24 kinds of extracts were obtained by hexane, acetone, methanol and water. The antioxidant activity of the extracts was determined by β-carotene color stands method and also ABTS radical removal and DPPH radical removal activity was determined by using the method of CUPRAC. The inhibition activity of the enzyme acetylcholinesterase and butyrylcholinesterase, associated with Alzheimer's disease, was determined by using the spectroscopic method of in vitro Ellman method.mobley s method was used for determination of urease inhibition activity. When the same solvent was used, the antioxidant activities of various extracts obtained by different methods showed diffirence significantly. Significant differences were observed in the different extracts obtained by the same method (p<0.05 ). It was observed that anticholinesterase activity of cooked samples were higher than the raw samples. REFERECE 1 Tong H, Xia, Feng K, Sun G, Gao X, Sun L, Jiang R, Tian D, Sun X. Structural characterization and in vitro antitumor activity of a novel polysaccharide isolated from the fruiting bodies of Pleurotus ostreatus. Bioresource Technology 100, , Papandreou Ma, Dimakopoulou A, Linardaki Zı, Cordopatis P, Klimis Zacas D, Margarity M, Lamari Fn. Effect of polyphenol-rich wild bluberry extract on cognitive performance of mice, brain antioxidant makers and acetylcholinesterase activity. Behavioural Brain Reserch 198, , Kıvrak İ, Duru ME, Öztürk M, Mercan, Harmandar M, Topçu G. Antioxidant, anticholinesterase and antimicrobial constituents from the essential oil and ethanol extract of Salvia potentillifolia. Food Chemistry 116 (2), ,