Alcohol can also intensify the side effects of some medications. This second interaction is what can happen when you mix ibuprofen and alcohol. In most cases, consuming a small amount of alcohol while taking ibuprofen is not harmful. However, taking more While it is generally safe to take ibuprofen and drink alcohol, it is highly recommended that you limit the amount of alcohol you drink while taking any medication, especially ibuprofen. Alcohol can irritate your stomach.