Phrase most commonly used in Memphis, TN. Used before and after a sentence to emphasize a point. Examples are readily portrayed in the Oscar nominated move Hustle and Flow. Easiest way to tell if someone is from Memphis. They cant help saying Mane before a sentence. Sometimes used in the Bay area as well but with a more southern slang. Were independly created.

Mane, Im tellin ya mane, its hard out here mane.
Mane I know you aint gone let him do ya like that mane.