Under some versions of x11-drivers/nvidia-drivers, GNOME Shell system tray shows graphical corruption (all icons are rendered identically). This problem is fixed in driver versions 280.13 and newer.

All versions of x11-drivers/nvidia-drivers are incompatible with GNOME's color management support. This is because GNOME's color management code relies on XRandR, and NVIDIA's support for XRandR is currently incomplete. There is no workaround at this time.

As reported in bug #375615, for some people, certain versions of x11-drivers/nvidia-drivers (275.28, 280.13, and 285.03 are known to be affected) cause some Gtk+ applications to hang when terminating. One effect of this is to make GDM freeze after the password has been entered; similarly, GNOME will freeze when logging out. The affected versions of nvidia-drivers have been masked. To prevent this problem, make sure to use an unmasked driver version, for example 275.09.07 or 285.05.09.