Alpha-L-fucosidase putative active site

α-L-fucosidase (EC 3.2.1.51) [1] is a lysosomal enzyme responsible for
hydrolyzing the α-1,6-linked fucose joined to the reducing-end
N-acetylglucosamine of the carbohydrate moieties of glycoproteins. Deficiency
of α-L-fucosidase results in the lysosomal storage disease fucosidosis.

A cysteine residue is important for the activity of the enzyme. There is only
one cysteine conserved between the sequence of mammalian α-L-fucosidase
and that of the slime mold Dictyostelium discoideum. We have derived a pattern
from the region around that conserved cysteine.

Note:

These proteins belong to family 29 in the classification of glycosyl
hydrolases [2,E1].

Last update:

May 2004 / Text revised.

Technical section

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