In the present study, we addressed this issue by blocking neuronal activity in the putamen via local injection of the GABA A receptor agonist muscimol into the putamen of monkeys engaged in a reinforcement-based multi-step choice task. (springer.com)

citation needed] When consumed, some percentage of muscimol goes un-metabolized and thus excreted in urine, a phenomenon exploited by practitioners of the traditional entheogenic use of Amanita muscaria. (wikipedia.org)

Atypical of the effect profile of sedative drugs generally however, muscimol, like Z-drugs, can cause hallucinogenic changes in perception. (wikipedia.org)

It is suggested that the present findings are due to a presynaptic nigral effect of muscimol on the GABAergic autoreceptors of the striatonigral terminals and to a consequent disinhibition of the reticulata GABAergic output. (jneurosci.org)