Countering

Choosing someone such as Miss Fortune or Caitlyn who have strong early games can easily deny Vayne from farming as Vayne has a relatively weak early game. Avoid pushing the lane as Tumble de Vayne makes her an exceptional farmer under turret, and has strong chasing potential.

the potential to duel with you and her kit will naturally round out
late-game when teamfights become dominant, where the fights become more
stationary and targets become harder to focus.

Once Vayne obtains Final Hour at level 6, her dueling potential increases exponentially and she

essentially "jumps" to her mid-game potentially immediately before most
other Attack Damage Carries. The Attack Damage and movement speed boosts
are huge given how early in the game it is and stealth detection is
much harder to afford earlier on. Respect her presence at level 6 if you
haven't pulled a significant advantage over her and avoid dueling her
if possible.

Vayne is one of the most powerful duelists in game and is well known and

feared as one of the most powerful marksman if fully build. It is
critical to keep her early and mid-game crippled.

Marksmen are usually easy prey to one-burst-wonder assassins, especially Zed and LeBlanc . Vayne is by far not in this category, her ability to carefully move around

the battlefield, drain-tank while evading attacks with stealth from Final Hour and bursting/peeling with Condemn makes her complicated to kill by surgical, tactical and careful

assassins as she can often prevent their abilities to properly flow for a
combo.

Silver Bolts is relatively easy to counteract contrary to popular belief.

[[File:{{{Frozen Heart}}} item.png|20px|alt=|Frozen Heart|link=Frozen Heart]] Frozen Heart is extremely detrimental to Vayne because the armor portion of the item counters her lack of magic damage

and the long-ranged -15% attack speed aura is practically unavoidable
in teamfights. [[File:{{{Randuin's Omen}}} item.png|20px|alt=|Randuin's Omen|link=Randuin's Omen]] Randuin's Omen is also especially useful against Vayne as one proc of slow will significantly cripple her true damage and mobility. Because Vayne relies on her mobility in order to survive in teamfights due to her

short range, the movement speed slow will make her an easy target to
focus. As such, even building an early [[File:{{{Warden's Mail}}} item.png|20px|alt=|Warden's Mail|link=Warden's Mail]] Warden's Mail will have noticeable effects against her.

if the target's lifebar isn't noticeably large but is constantly renewed from either high lifesteal or abilities such as Sadism, the damage from Silver Bolts becomes significantly less noticeable.

Battling her only in teamfights forces her to switch targets, resulting in fewer Silver Bolts procs.

Mages with targeted burst damage/crowd controls such as LeBlanc or Ryze can easily dispatch Vayne as her mobility and Tumble are primarily anti-skillshot oriented. Targeted abilities that apply targeted hard crowd control's such as Infinite Duress de Warwick and Nether Grasp de Malzahar prevents Vayne from retaliating with her mobility and lifesteal resulting in an easy kill.

Ryze is especially effective because [[File:{{{Frozen Heart}}} item.png|20px|alt=|Frozen Heart|link=Frozen Heart]] Frozen Heart is a core item in his build and his Rune Prison shuts down Vayne's mobility and Tumble, which also shuts down her stealth when Final Hour is active.

It's recommended not to fight Vayne in the jungle as there are more walls for her to stun with her Condemn .

Taking a [[File:{{{Vision Ward}}} item.png|20px|alt=|Vision Ward|link=Vision Ward]] Vision Ward with you or activating an [[File:{{{Oracle's Lens}}} item.png|20px|alt=|Oracle's Lens|link=Oracle's Lens]] Oracle's Lens is useful against Final Hour as her stealth will be useless, shutting down her primary method of reaching squishier targets of interest.