Cannabidiol, or CBD, Benefits for Pain, Mental Illness & Anxiety

Cannabidiol, or CBD, Benefits for Pain, Mental Illness & Anxiety

The use of medical marijuana continues to be an emotionally and politically charged issue. Although cannabis oil preparations have been used in medicine for millennia, the concern over the dangers of abuse led to the banning of the medicinal use of marijuana in the 1930s. Yet there are actually many CBD benefits to health.

Only recently, marijuana and chemically-related compounds have come back to being considered of therapeutic value. A prominent compound found in marijuana or cannabis, CBD, or cannabidiol, has been shown to treat numerous diseases. Researchers believe that in view of the very low toxicity and the generally benign side effects of CBD, neglecting or denying CBD benefits and its clinical potential is simply unacceptable.

What Is CBD?

CBD is one of over 60 compounds found in cannabis that belong to a class of ingredients called cannabinoids. Until recently, THC (tetrahydrocannabinol) was getting most of the attention because it’s the ingredient in cannabis that produces mind-altering effects in users, but CBD is also present in high concentrations — and the medical world is realizing that its list of medical benefits continues to grow.

CBD is the major nonpsychoactive component of Cannabis sativa. According to a 2013 study published in the British Journal of Clinical Pharmacology, CBD benefits including acting in some experimental models as an anti-inflammatory, anticonvulsant, antioxidant, antiemetic, anxiolytic and antipsychotic agent, and is therefore a potential medicine for the treatment of neuroinflammation, epilepsy, oxidative injury, vomiting and nausea, anxiety and schizophrenia.

Research is beginning to show that CBD is different than other well-studied cannabinoids. All cannabinoids act as ligands, meaning they dock onto the binding site of a protein and have the ability to modulate a receptor’s behavior. CB1 receptors are widely distributed but are particularly abundant in areas of the brain, including those concerned with movement, coordination, pain and sensory perception, emotion, memory, cognition, autonomic and endocrine functions.

CB2 receptors are found mostly in the immune system, and they seem to reduce inflammation and certain kinds of pain. Although cannabinoids all have similar structures, they display a wide array of actions at each of the different receptors.

8 Proven CBD Benefits

1. Relieves Pain and Inflammation

Among common CBD benefits, natural pain relief tops the list for many. Evidence suggests that cannabinoids may prove useful in pain modulation by inhibiting neuronal transmission in pain pathways. A 2012 study published in the Journal of Experimental Medicine found that CBD significantly suppressed chronic inflammatory and neuropathic pain in rodents without causing analgesic tolerance. Researchers suggest that CBD and other nonpsychoactive components of marijuana may represent a novel class of therapeutic agents for the treatment of chronic pain.

According to a 2007 meta-analysis conducted in Canada, the combination of CBD and THC buccal spray was found to be effective in treating neuropathic pain in multiple sclerosis, which can be debilitating for 50 percent to 70 percent of MS patients.

2. Has Antipsychotic Effects

Research shows that CBD benefits include producing antipsychotic effects. It appears to have a pharmacological profile similar to that of atypical antipsychotic drugs as seen in using behavioral and neurochemical techniques in animal studies. Additionally, studies show that CBD prevents human experimental psychosis and is effective in open case reports and clinical trials in patients with schizophrenia, with a remarkable safety profile.

3. Reduces Anxiety

Studies using animal models of anxiety and involving healthy volunteers clearly suggest an anxiolytic-like effect of CBD. Cannabidiol has shown to reduce anxiety in patients with social anxiety disorder and researchers suggest that it may also be effective for panic disorder, obsessive-compulsive disorder, social anxiety disorder, and post-traumatic stress disorder.

A 2011 study aimed to compare the effects of a simulation public speaking test on healthy control patients and treatment-naive patients with social anxiety disorder. A total of 24 never-treated patients with social anxiety disorder were given either CBD or placebo 1.5 hours before the test. Researchers found that pretreatment with CBD significantly reduced anxiety, cognitive impairment and discomfort in their speech performance, and significantly decreased alertness in anticipation of their speech. The placebo group presented higher anxiety, cognitive impairment, and discomfort.

4. Helps to Fight Cancer

Several scientific reports demonstrate that CBD benefits include possessing antiproliferative, pro-apoptotic effects that inhibit cancer cell migration, adhesion, and invasion. A 2006 study published in the Journal of Pharmacology and Experimental Therapeutics found for the first time that CBD potently and selectively inhibited the growth of different breast tumor cell lines and exhibited significantly less potency in non-cancer cells.

In 2011, researchers added light on the cellular mechanism through which CBD induces cell death in breast cancer cells. They showed that CBD induced a concentration-dependent cell death of both estrogen receptor-positive and estrogen receptor-negative breast cancer cells. They also found that the effective concentrations of CBD in tumor cells have little effect on non-tumorigenic, mammary cells.

CBD behaves as a non-toxic compound and studies show that doses of 700 milligrams per day for 6 weeks did not show any overt toxicity in humans, suggesting that it can be used for prolonged treatment. Not only does the research show that CBD benefits including being effective in fighting breast cancer cells, but data also suggests that it can be used to inhibit the invasion of lung and colon cancer, plus it possesses anti-tumor properties in gliomas and has been used to treat leukemia.

5. Relieves Nausea

Cannabis has been used for centuries for the suppression of nausea and vomiting. Research has revealed that among more than 80 cannabinoid compounds found in marijuana, both the intoxicant THC and the non-intoxicant CBD helps to get rid of nausea and vomiting in animal studies. A 2012 study published in the British Journal of Pharmacology found that CBD benefits including possessing anti-nausea and antiemetic effects when it was administered to rats. Researchers found that CBD acts in a diphasic manner, meaning that in low doses it suppresses toxin-induced vomiting, but in high doses, it increases nausea or has no effect.

6. May Treat Seizures and Other Neurological Disorders

A 2014 survey conducted by researchers at Stanford University was presented to parents belonging to a Facebook group dedicated to sharing information about the use of cannabidiol-enriched cannabis to treat their child’s seizures. Nineteen responses met the inclusion criteria for the study: a diagnosis of epilepsy and the current use of CBD-enriched cannabis. The average number of anti-epileptic drugs tried before using CBD cannabis was 12. Sixteen (84 percent) of the 19 parents reported a reduction in their child’s seizure frequency while taking CBD cannabis. Of these, two (11 percent) reported complete seizure freedom, eight (42 percent) reported a greater than 80 percent reduction in seizure frequency, and six (32 percent) reported a 25–60 percent seizure reduction. Other beneficial effects included increased alertness, better mood, and improved sleep; while side effects included drowsiness and fatigue.

Later in 2014, researchers reported on preliminary results of a study involving children with treatment-resistant epilepsies in an expanded access “compassionate use program.” Patients received a purified 98 percent oil-based CBD extract called Epidiolex, which is made by GW Pharmaceuticals. After 3 months of treatment, 39 percent of the 23 patients had more than a 50 percent reduction in seizures, with a 32 percent median reduction. These preliminary results support the animal studies and survey reports that CBD may be a promising treatment for treatment-resistant epilepsy and it is generally well-tolerated in doses up to 25 milligrams per kilogram of body weight.

7. Lowers Incidence of Diabetes

A 2006 study found that CBD treatment significantly reduced the incidence of diabetes in non-obese diabetic mice from an incidence of 86 percent in non-treated mice to an incidence of 30 percent in CBD-treated mice. CBD benefits also showed a significant reduction of plasma levels of pro-inflammatory cytokines. A histological examination of the pancreatic islets of the CBD-treated mice revealed significantly reduced insulitis. (16)

In 2013, the American Journal of Medicine published a study that highlighted the impact of marijuana use on glucose, insulin and insulin resistance among U.S. adults. The study included 4,657 adult men and women from the National Health and Nutritional Examination Survey from 2005 to 2010. Of the participants, 579 were current marijuana users and 1,975 were past users. The researchers found that current marijuana use was associated with 16 percent lower fasting insulin levels. They also found significant associations between marijuana use and smaller waist circumferences, a factor connected to the onset of diabetes symptoms.

8. Promotes Cardiovascular Health

A 2013 study published in the British Journal of Clinical Pharmacology reports that CBD protects against the vascular damage caused by a high glucose environment, inflammation or the induction of type 2 diabetes in animal models; plus, CBD proved to reduce the vascular hyperpermeability (which causes leaky gut) associated with such environments.

Related posts

CBD and Your Dog Holistic vets have been sending us some interesting reports about the benefits of CBD oil for dogs in their care. A senior Staffordshire Terrier had a 6cm mammary tumor and metastasis that disappeared in 3 months and didn’t come back. A Jack Russell Terrier had a severe heart murmur and painful…

It is difficult to know which hemp-derived CBD products actually contain CBD and are safe to consume, as there is currently no federal regulation of CBD products. Many hemp-derived CBD products are mislabeled. A study reported in the Journal of the American Medical Association indicated that 69% of 85 products surveyed had an incorrect amount of CBD and/or THC on the product label….

Can you really take CBD oil for pain? Is this a legitimate form of alternative medicine? More people are asking these questions as they gravitate towards natural and holistic approaches. It is not healthy, after all, to become too dependent on traditional pain relievers, such as NSAIDs like Ibuprofen or Tylenol. Let’s examine the science…

CBD for Pets How it Works Cannabidiol (CBD) is a substance that is found in a cannabis plant. Unlike its counterpart THC that creates a ‘buzz,’ CBD is not a psychoactive stimulus, but rather provides your pet with a calming sensation and pain-relieving sensations without harming them with potential intoxicating effects. You may be interested…

CBD is an anti-inflammatory that can help with seizures, joint pain, and many other health problems. Plus, since CBD doesn’t get you high, it’s more accepted and easier to access than THC. Science is certain that CBD has positive effects on the body. What’s unknown is exactly which medical problems the cannabinoid can help. Despite this…

FOOD AND DRUG ADMINISTRATION (FDA) DISCLOSURE
These statements have not been evaluated by the FDA and are not intended to diagnose, treat or cure any disease. Always check with your physician before starting a new dietary supplement program.
* Cannabidiol (CBD) is a natural constituent of hemp oil.

Products on this site contain a value of 0.3% or less THC (or no more than 0.3% THC)