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Background: In the treatment of non-small-cell lung cancer (NSCLC), solvent-based paclitaxel (sb-paclitaxel) plus cisplatin can be expected to have high response rate, but strong neurotoxicity is observed. Currently, nanoparticle albumin-bound paclitaxel (nab-paclitaxel) plus carboplatin is considered as one of the standard regimen, and a higher response rate and lower neurotoxicity are expected as compared with sb-paclitaxel plus carboplatin. Therefore, we planned this study to evaluate the efficacy and safety of nab-paclitaxel plus cisplatin in chemotherapy-naïve patients with advanced NSCLC.