IDAC Seminar, 26 August 2016

Laboratory of Protein Metabolism, Graduate School of Pharmaceutical Sciences,The University of Tokyo

Person-in-charge

Hiroki SEKINE Dept. Gene Expression Regulation・ext8553

Abstract

The proteasome is an essential intracellular proteolytic enzyme complex that degrades ubiquitinated proteins in eukaryotes. Increase or decrease in the proteasome activity has been shown to be associated with the pathogenesis of human diseases such as malignancies, inflammation, neurodegeneration, and aging. Thus, understanding the mechanisms that regulate the proteasome in mammals is of importance. In this talk, I will present our recent work regarding qualitative and quantitative regulation of the proteasome and their biological consequence.