Both vitamin A and isotretinoin can cause toxic symptoms if taken in excess. It is presumed likely that simultaneous use of vitamin A and isotretinoin would tend to amplify the risk. For this reason, people using isotretinoin should not take vitamin A at doses higher than the recommended daily allowance; in fact, because most people get enough vitamin A from the diet, it might be preferable to take no vitamin A supplements at all. (Supplements that use
beta-carotene
to supply vitamin A are probably safe.)

Because isotretinoin can cause birth defects, women who use it are often advised to take
oral contraceptives
(birth control pills). The herb St. John’s wort is thought to interact with birth control pills and reduce their effectiveness, raising the risk of pregnancy.
1-3
For this reason, people taking accutane and oral contraceptives should avoid using St. John’s wort.

Revision Information

This content is reviewed regularly and is updated when new and relevant evidence is made available. This information is neither intended nor implied to be a substitute for professional medical advice. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with questions regarding a medical condition.