tag:blogger.com,1999:blog-1574140332407591967.post8100638587023113720..comments2017-12-04T22:33:32.367-08:00Comments on Spirochetes Unwound: Resurgence of Borrelia burgdorferi in mice a year after antibiotic treatmentMicrobe Fanhttp://www.blogger.com/profile/00832169199776258021noreply@blogger.comBlogger17125tag:blogger.com,1999:blog-1574140332407591967.post-72287973146295907482016-05-20T07:33:54.303-07:002016-05-20T07:33:54.303-07:00that would be great, thank you so much!that would be great, thank you so much!Sebastien Millonhttps://www.blogger.com/profile/06384643621878633512noreply@blogger.comtag:blogger.com,1999:blog-1574140332407591967.post-89078203967064898352016-05-20T07:33:34.867-07:002016-05-20T07:33:34.867-07:00This comment has been removed by the author.Sebastien Millonhttps://www.blogger.com/profile/06384643621878633512noreply@blogger.comtag:blogger.com,1999:blog-1574140332407591967.post-38103881918035031712016-05-20T01:11:39.483-07:002016-05-20T01:11:39.483-07:00I have this book, i could give You the references ...I have this book, i could give You the references to the MS studies on borrelia cultures from the chapter on spirocheteswrotekhttps://www.blogger.com/profile/06872869750131587895noreply@blogger.comtag:blogger.com,1999:blog-1574140332407591967.post-8854657153664629452016-05-19T16:27:03.529-07:002016-05-19T16:27:03.529-07:00I&#39;ve been very interested in Mattman&#39;s wor...I&#39;ve been very interested in Mattman&#39;s work, I know she studied under Gabriel Steiner who was the spirochetal expert of his time. Grier wrote an interesting bit about her: http://www.lymeneteurope.org/info/cell-wall-deficient-bacteria <br /><br />I think she was finding both borrelia and another spirochetal organism in quite a few MS patients in a study she ran but have been unable to track down the paper so I have no idea on the specifics. <br /><br />This was a rather intriguing release in the last couple days from Dr MacDonald&#39;s work: http://www.prnewswire.com/news-releases/lyme-bacteria-hides-inside-parasitic-worms-causing-chronic-brain-diseases-300270742.html Need more research but it is interesting.<br /><br />There is also a nice video lecture by Mattman on youtube, but other than that one lecture it is very hard to find much information on her. I&#39;ll likely invest in getting her book at some point.<br /><br />I think the million dollar question is how common is the borrelia organism in the human host? how often does it cause disease? could it be part of the natural human microbial environment? are there other more important factors at play like immune system genetics that complicate the ability to handle this pathogen? I also imagine the wide genetic diversity of the borrelioses plays a factor in pathogenicity and illness manifestations as well, along with the other pathogens harbored in the human host. Immune system could reach a tipping point where it might no longer be able to keep a lid on the pathogens causing the system to go haywire. Guesses.Sebastien Millonhttps://www.blogger.com/profile/06384643621878633512noreply@blogger.comtag:blogger.com,1999:blog-1574140332407591967.post-14829566458288464132016-05-19T16:09:52.497-07:002016-05-19T16:09:52.497-07:00Great thanks for the head&#39;s up!Great thanks for the head&#39;s up!Sebastien Millonhttps://www.blogger.com/profile/06384643621878633512noreply@blogger.comtag:blogger.com,1999:blog-1574140332407591967.post-11728254674333219262016-05-19T03:51:48.741-07:002016-05-19T03:51:48.741-07:00Here is medium that Lida Mattman and Phillips used...Here is medium that Lida Mattman and Phillips used to grow spirochetes from blood borellia but also Multiple Sclerosis patients... http://lymerick.net/MPM-2001-medium-Bb.html She says there is nothing easier in the world that not growing them if You dont do it rightwrotekhttps://www.blogger.com/profile/06872869750131587895noreply@blogger.comtag:blogger.com,1999:blog-1574140332407591967.post-22387447681987941492016-05-19T03:14:51.768-07:002016-05-19T03:14:51.768-07:00Are You familiar with this movie ? https://youtu.b...Are You familiar with this movie ? https://youtu.be/WozrCFW0mRM Please pay attention how laboratory tried to culture spirochetes and could NOT, untill they called Lida Mattmanwrotekhttps://www.blogger.com/profile/06872869750131587895noreply@blogger.comtag:blogger.com,1999:blog-1574140332407591967.post-72611857088911366862016-05-19T03:09:52.554-07:002016-05-19T03:09:52.554-07:00This comment has been removed by the author.wrotekhttps://www.blogger.com/profile/06872869750131587895noreply@blogger.comtag:blogger.com,1999:blog-1574140332407591967.post-88617602720698587692016-05-19T03:00:41.517-07:002016-05-19T03:00:41.517-07:00so in Your opinion, taking under consideration cur...so in Your opinion, taking under consideration current knowledge, what is most probable reason for PTLSD ? wrotekhttps://www.blogger.com/profile/06872869750131587895noreply@blogger.comtag:blogger.com,1999:blog-1574140332407591967.post-7720018387094821062016-05-19T02:50:58.796-07:002016-05-19T02:50:58.796-07:00Apparently the spirochetal forms are very hard to ...Apparently the spirochetal forms are very hard to find in a host, the spirochetes convert fast into L - forms and we are dealing with Borrelia not spirochetes, as concerning the names... The same thing is in syphilis, 3rd stage of syphilis is that spirochetes are almost impossible to be isolated...Why would that be ? Are You familiar with Lida Mattman stealth pathogens book ?wrotekhttps://www.blogger.com/profile/06872869750131587895noreply@blogger.comtag:blogger.com,1999:blog-1574140332407591967.post-11093721043783137962016-05-18T15:52:54.993-07:002016-05-18T15:52:54.993-07:00Maybe I should have said that there is still littl...Maybe I should have said that there is still little evidence that they cause disease. They may be capable of causing disease, but the limitations of Barthold&#39;s mouse model prevented them from answering the question (the limitation being the inability of his mice to infiltrate infected tissues with inflammatory cells even when left untreated).Microbe Fanhttps://www.blogger.com/profile/00832169199776258021noreply@blogger.comtag:blogger.com,1999:blog-1574140332407591967.post-55913474825434664032016-05-18T13:41:04.228-07:002016-05-18T13:41:04.228-07:00Results of the first phase were published in this ...Results of the first phase were published in this paper: http://www.ncbi.nlm.nih.gov/pubmed/24523212. The main goal of this pilot study was to see if it is safe to do xenodiagnosis on Lyme disease patients. I&#39;ll say something about this study in a future post.Microbe Fanhttps://www.blogger.com/profile/00832169199776258021noreply@blogger.comtag:blogger.com,1999:blog-1574140332407591967.post-82514602498947530312016-05-18T05:45:32.762-07:002016-05-18T05:45:32.762-07:00&quot;Whether these unculturable spirochetes are c...&quot;Whether these unculturable spirochetes are capable of generating an inflammatory condition necessary for disease is less clear, though mice do appear to generate a unique cytokine profile in response to the persisting spirochetes.&quot; why would not they cause disease ? are they damaged somehow ?wrotekhttps://www.blogger.com/profile/06872869750131587895noreply@blogger.comtag:blogger.com,1999:blog-1574140332407591967.post-35852507300503720232016-05-18T05:34:45.490-07:002016-05-18T05:34:45.490-07:00P.S. what are the results of this phase 1 ? P.S. what are the results of this phase 1 ? wrotekhttps://www.blogger.com/profile/06872869750131587895noreply@blogger.comtag:blogger.com,1999:blog-1574140332407591967.post-88865062440541140492016-05-18T05:02:51.684-07:002016-05-18T05:02:51.684-07:00Very interesting blog You have. Very interesting blog You have. wrotekhttps://www.blogger.com/profile/06872869750131587895noreply@blogger.comtag:blogger.com,1999:blog-1574140332407591967.post-64588449862911595172016-05-17T10:19:04.586-07:002016-05-17T10:19:04.586-07:00Autopsies aren&#39;t necessary just yet. One group...Autopsies aren&#39;t necessary just yet. One group is recruiting volunteers with post-treatment symptoms to see if Lyme Borrelia can be detected by tick xenodiagnosis (https://clinicaltrials.gov/ct2/show/NCT02446626). The first phase of this study has been completed (https://clinicaltrials.gov/ct2/show/NCT01143558).Microbe Fanhttps://www.blogger.com/profile/00832169199776258021noreply@blogger.comtag:blogger.com,1999:blog-1574140332407591967.post-40794149959732066812016-05-16T09:08:33.801-07:002016-05-16T09:08:33.801-07:00Very interesting. Thank you for sharing your knowl...Very interesting. Thank you for sharing your knowledge and thoughts on these animal studies concerning borrelia persistence and spirochetal viability after treatment. <br /><br />I&#39;m wondering if at some point doing autopsy work on humans who have been treated with antibiotics but still had persisting symptoms might not reveal some answers in terms of the viability of spirochetes post antibiotic exposure. The organism is highly tropic, so it would be interesting to see what tissues like brain autopsies might show, there have been some very small scale studies but not much follow up in this arena (to my knowledge).Sebastien Millonhttps://www.blogger.com/profile/06384643621878633512noreply@blogger.com