Cytotoxic activities of new iron(III) and nickel(II) chelates of some S-methyl-thiosemicarbazones on K562 and ECV304 cells

Atasever, Belkıs and Ülküseven, Bahri and Bal-Demirci, Tülay and Erdem-Kuruca, Serap and Solakoğlu, Zeynep (2009) Cytotoxic activities of new iron(III) and nickel(II) chelates of some S-methyl-thiosemicarbazones on K562 and ECV304 cells. (Accepted/In Press)

Abstract

The S-methyl-thiosemicarbazones of the 2-
hydroxy-R-benzaldehyde (R= H, 3-OH 3-OCH3 or 4-OCH3)
reacted with the corresponding aldehydes in the presence of
FeCl3 and NiCl2. New ONNO chelates of iron(III) and nickel
(II) with hydroxy- or methoxy-substitued N1,N4-diarylidene-Smethyl-
thiosemicarbazones were characterized by means of
elemental analysis, conductivity and magnetic measurements,
UV-Vis, IR and 1H-NMR spectroscopies. Cytotoxic activities
of the compounds were determined using K562 chronic
myeloid leukemia and ECV304 human endothelial cell lines
by MTT assay. It was determined that monochloro N1-4-
methoxysalicylidene-N4-4-methoxysalicylidene-S-methylthiosemicarbazidato-
iron(III) complex showed selective
anti-leukemic effects in K562 cells while has no effect in
ECV304 cells in the 0.53 μg/ml (IC50) concentrations. Also,
some methoxy-substitued nickel(II) chelates exhibit high
cytotoxic activitiy against both of these cell lines in low
concentrations. Cytotoxicity data were evaluated depending on
cell lines origin and position of the substituents on aromatic rings.

Item Type:

Article

Uncontrolled Keywords:

Thiosemicarbazone . Iron complex . Nickel complex . Cytotoxicity .MTT

Subjects:

UNSPECIFIED

ID Code:

12312

Deposited By:

Belkıs Atasever Arslan

Deposited On:

29 Oct 2009 21:37

Last Modified:

07 Jun 2010 15:42

Available Versions of this Item

Cytotoxic activities of new iron(III) and nickel(II) chelates of some S-methyl-thiosemicarbazones on K562 and ECV304 cells. (deposited 29 Oct 2009 21:37)[Currently Displayed]