Another major business district is located in the more suburban area east of the city on Hurstbourne Parkway. This area is considered Louisville's key edge city—a relatively new concentration of business, shopping and entertainment outside a traditional urban area. Louisville also boasts a large number of parks, with 122 parks covering more than 14,000 acres (57 km²).

Major roads extend outwards from the downtown area to all directions, like the spokes of a wheel. Many of these, such as Bardstown Road, are former privately owned turnpikes, which were made free roads by the city in 1901. Thus, as is typical of cities built on property organized by the Metes and bounds system, the old spoke roads extend relatively erratically from the city center, with turns and curves based on old geography and now-forgotten property ownership. In areas such as downtown, Old Louisville, and the West End, old turnpikes and roads were rebuilt to fit the grid, but in other areas, the spoke roads remained as the old farms they once served were developed. Where the spoke roads remained unaltered, smaller roads were built in between them as the farms were developed, either in a relatively gridiron style in older sections, or in curvilinear styles, often with many cul-de-sacs, in newer areas.

Louisville has traditionally been divided up into three sides of town: the West End, the South End, and the East End. In 2003, Bill Dakan, a University of Louisville geography professor, said that the West End, west of 7th Street and north of Algonquin Parkway, is "a euphemism for the African-American part of town" although he points out that this belief is not entirely true, and most African Americans no longer live in areas where more than 80% of residents are black. Nevertheless, he says the perception is still strong.[6] According to the Greater Louisville Association of Realtors, the lowest median home values are west of Interstate 65 in the West and South Ends, the middle range of home values are between Interstates 64 and 65 in the South and East Ends, and the highest median home values are north of Interstate 64 in the East End.[7] Immigrants from Southeast Asia tend to settle in the South End, while immigrants from Eastern Europe settle in the East End.[8]

The most affluent residential areas are to the east of downtown Louisville. The nine richest locations by per capita income in Kentucky, and 19 of the top 20 such locations, are found in this East End, which trace their origins to several 19th century summer colonies for wealthy Louisvillians. The nearest to downtown, as well as the wealthiest in terms of average income, is Mockingbird Valley, and the two most prominent and oldest Eastern Jefferson County cities are Anchorage and Glenview.

There are also two areas which are sometimes considered to be their own side of town. The area east of I-65, south of Eastern Parkway, and west of Bardstown Road is economically, culturally and topographically a buffer zone between the East and South sides, and is routinely claimed by both residents and outsiders as belonging to either side.

The interior areas of the city's east and south ends are also sometimes considered by some to be their own side of town, sometimes called the "Inner East side". The area basically from Old Louisville, along Eastern Parkway to The Highlands, and to the Butchertown and Clifton areas have seen an influx of young professionals in recent decades. These areas are home to mostly singles and non-families, are much more liberal than the rest of the city, and feature pedestrian-friendly shopping, with many eclectic shops. Most of these neighborhoods are either partly or entirely in historic preservation districts.

Some notable tall buildings outside of the downtown area are 1400 Willow Avenue, a 21-story condominium complex near Cherokee Park completed in 1980; Baptist Towers, a 17-story retirement living community in Old Louisville; and the suburban office buildings Kaden Tower (15 stories, completed in 1966), Watterson Towers (16 stories, completed in 1972), and Hurstbourne Place (13 stories, completed in 1982).

The primary roadway project will be the controversial $3.9 billion Ohio River Bridges Project, which includes the reconstruction of the Kennedy Interchange, where Interstates 64, 65 and 71 meet. It also includes the construction of an I-265 eastern span and the dualization of the I-65 downtown span.

RiverPark Place, a mixed low and high-rise apartment/condominium development covering 40 acres (160,000 m2) including a 150-slip marina between River Road and the Ohio River, near Towhead Island. A 16-foot wide walkway is to be developed along the river's edge, connecting with Waterfront Park to the west, and Beargrass Creek and Eva Bandman Park to the east. Status: On hold since 2008, resumed late in 2011.

Park DuValle is a $200 million investment that is revitalizing an existing neighborhood by applying principles of new urbanism into its design. Park Duvalle was formerly a massive public workshousing project with barrack-styled housing that became essentially a warehouse for low-income residents. The new community is based on a mixed-income design that features pedestrian-friendly neighborhoods, large recreation and civic spaces, single-family homes, duplexes and small townhouse multi-family structures in period-style design. Status: Completed.

Norton Commons, located 20 minutes northeast of downtown near I-71 and I-265, is a 595-acre (2.41 km2) mixed-use development based on new urbanism principles. It's a multi-year development and will feature single-family homes, duplexes and townhomes, along with traditional looking storefronts, civic spaces and parks in a variety of period-inspired designs all within walking distance. Status: Under construction, Plans call for a total of 2,900 residences and 560,000 square feet (52,000 m2) of commercial space, with completion in 2020.

Liberty Green, a 29-acre (120,000 m2) $233 million project that will have 448 rental apartments/townhomes and 250 home-ownership townhomes in the Phoenix Hill neighborhood just east of downtown Louisville, and will include a recreational facility and possibly some commercial space. Status: Rentals scheduled for completion by 2009, Sales of townhomes by 2018.

KFC Yum! Center, a 22,000-seat arena in Downtown Louisville, bounded by River Road and Main, Second, and Third Streets, that is now the home for the University of Louisville men's and women's basketball teams. The arena was the main part of a $450 million project that also included a 975-space parking garage and a floodwall; the arena itself cost $252 million. Status: Completed; opened October 10, 2010.

Nucleus Research Park, In 2007 U of L announced plans to create a nine-acre medical research park on the so-called Haymarket property roughly bounded by Market, Preston, Brook, and Jefferson Streets, along I-65 in Downtown Louisville, with 1,000,000 square feet (93,000 m2) of research space. The project is expected to cost $300 million and would be constructed from 2009 to 2017. A 200,000-square-foot, eight-story, $18 million building, is the first in a series of structures, broke ground in July 2011, and is expected to open in May 2013. Status: Under Construction.[9]