The APCC has its headquarters at Gandhi Bhawan, near Nampally in Hyderabad, the capital city of Andhra Pradesh. The APCC is responsible for Congress party units of all the 23 districts in Andhra Pradesh.

After the bifurcation, the current chief is N. Raghu Veera Reddy, ex-Minister for Revenue in the state government of Andhra Pradesh. He was appointed on 11 March 2014. With the bifurcation of Andhra Pradesh, the Congress formed separate committees for the two regions.