Cannabis (Marijuana) is a popular psychoactive plant that is often used medically and recreationally. Cannabis is also unique in that it contains a psychoactive substance, THC, which contains no nitrogen and is not an indole, tryptamine, phenethylamine, anticholinergic (deliriant), or a dissociative drug. Cannabis plants tend to vary, with different strains producing dynamic balances of psychoactive cannabinoids (THC, CBD, etc.) that cause different strains to produce markedly different effects, popular strains often being hybrids of both Cannabis sativa and Cannabis indica. Some universities and research firms currently study the medicinal effects of cannabis. Many jurisdictions have laws regulating (or outright prohibiting) the sale and use of medical cannabis to treat pain, insomnia, and stimulate appetite.

Many of the psychedelic plants contain dimethyltryptamine (DMT), which is either snorted (Virola, Yopo snuffs), smoked, or drunk with MAOIs (Ayahuasca). It cannot simply be eaten as it is not orally active without an MAOI and it needs to be extremely concentrated to be smokable.

Acer saccharinum (Silver Maple Tree) was found to contain the indole alkaloid gramine (not active and extremely toxic) 0.05% in the leaves, so it is possible that other members of this plant family contain active compounds.[2]

Acacia farnesiana, Traces of 5-MeO-DMT[25] in fruit. β-methyl-phenethylamine, flower.[26] Ether extracts about 2-6% of the dried leaf mass.[27] Alkaloids are present in the bark[28] and leaves.[29] Amphetamines and mescaline also found in tree.[23]

Acacia podalyriaefolia, Tryptamine in the leaf,[7] 0.5% to 2% DMT in fresh bark, phenethylamine, trace amounts.[30] Although this species is claimed to contain 0.5% to 2% DMT in fresh bark the reference for this is invalid as there is no reference to Acacia Podalyriffolia anywhere in the reference article. Additionally, well known and proven extraction techniques for DMT have failed to produce any DMT or alkaloids from fresh bark or the leaves on multiple sample taken at various seasons. Should DMT actually exist in this species of Acacia then it exists in extremely small amounts and have failed to produce any alkaloids with Acid/Base extraction techniques using HCl/Na(OH)2. On the same note, more academic research is definitely required into the DMT content of this and other Australian Acacia species with proper chemical analysis of sample.[citation needed]

Recent studies have shown Nymphaea caerulea to have psychedelic properties, and may have been used as a sacrament in ancient Egypt and certain ancient South American cultures. Dosages of 5 to 10 grams of the flowers induces slight stimulation, a shift in thought processes, enhanced visual perception, and mild closed-eye visuals. Nymphaea caerulea is related to, and possesses similar activity as Nelumbo nucifera, the Sacred Lotus. Both Nymphaea caerulea and Nelumbo nucifera contain the alkaloids nuciferine and apomorphine, which have been recently isolated by independent labs.[citation needed]

These psychoactive effects make Nymphaea caerulea a likely candidate (among several) for the lotus plant eaten by the mythical Lotophagi in Homer's Odyssey.

Used in aromatherapy, Nymphaea caerulea is purported to have a "divine" essence, bringing euphoria, heightened awareness and tranquility.[citation needed]

Other sources cite anti-spasmodic and sedative, purifying and calming properties.

Produces vivid dreams after smoking. It is also employed by the Chontal people as a medicinal herb against gastrointestinal disorders, and is used as an appetizer, cathartic anti-dysentery remedy, and as a fever-reducing agent. Its psychedelic properties do not become apparent until the user is asleep.