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Online Cover This week features a Research Article that describes how the heart is more susceptible to radiation-induced damage when the transcription factor p53 is not present in cardiac endothelial cells. In the image, the darker area indicates a necrotic section of myocardium from a mouse with an endothelial cell–specific ablation of p53 that has been irradiated. [Image: Chang-Lung Lee/Duke University Medical Center]