anti-Trefoil Factor 2 (TFF2) Antibodies

Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. Additionally we are shipping Trefoil Factor 2 Kits (57) and Trefoil Factor 2 Proteins (34) and many more products for this protein.

More Antibodies against Trefoil Factor 2 Interaction Partners

Human Trefoil Factor 2 (TFF2) interaction partners

Data show that trefoil factor 2 (TFF2( urine levels continuously decreased with disease progression, TFF2 serum concentrations progressively increased from the early to later chronic kidney disease (CKD) stages, indicating changes in renal function and offering the potential to examine the course of CKD.

this work reveals that TFF2 has tumor-suppressor activity, which may, in part, be regulated by SMAD4 (show SMAD4 Antibodies).

Data indicate that the antitumor activity of trefoil factor 2 (TFF2) is mediated by an interaction with the transcription factor Sp3 (Sp3 (show SP3 Antibodies)) in gastric cancer cells.

Data show the important functions of TFF2 in the gastric mucus barrier, mucus epithelia, immune system, central nervous system, and during fertilization. It has been shown to interact with the gastric mucinMUC6 (show MUC6 Antibodies). [Review]

These findings suggest that the rs184432 and rs225359 polymorphisms in TFF1 (show TFF1 Antibodies) have protective effects for GC and contribute to the development of GC in Korean individuals.

Significantly higher levels of TFF2 were in patients with Multiple Organ Dysfunction Syndrome.

Pig (Porcine) Trefoil Factor 2 (TFF2) interaction partners

Low intestinal TFF2 expression was measured at early maturation stages. Weaning, however, was associated with a distinct response of increased TFF2 expression, indicating an important role in enhancing mucosal integrity.

Splenic TFF2 is released by vagally modulated memory T cells to suppress expansion of myeloid-derived suppressor cells (MDSC) through CXCR4 (show CXCR4 Antibodies). TFF2 is important to the anti-inflammatory reflex arc (show NOL3 Antibodies) and has an essential role in arresting MDSC proliferation.

Epithelial TFF2 is an important endogenous regulator of gut (show GUSB Antibodies) mucosal homeostasis that can modulate immune and epithelial compartments.

The Tff2 gene is expressed in the hypothalamus and is regulated by food intake. Knockout mice are leaner (show CACNA1A Antibodies) and have reduced fat mass compared to wild-type.

The increased expression of endogenous TFF2 in response to chronic allergic inflammation is insufficient to prevent the progression of airway inflammation and remodeling in a model of chronic allergic airways disease.

TFF2 (trefoil factor 2), an epithelial cell-derived repair molecule, is needed for the control of lung injury caused by the hookworm parasite Nippostrongylus brasiliensis and for type 2 immunity after infection.

results suggest that during retinal cell death periods, requiring a tightly regulated balance between cell survival and cell death, TFF2 acts pro-proliferative and pro-apoptotic at least in developing mouse retinae cultured in vivo

Trefoil Factor 2 (TFF2) Antigen Profile

Protein Summary

Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer and affect healing of the epithelium. The encoded protein inhibits gastric acid secretion. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21.