Ilaria Testa, working with Stefan Hell at the Max Planck Institute in Göttingen, Germany, has developed the REversible Saturable OpticaL Fluorescence Transitions (RESOLFT) technique for work in organotypic brain cultures. RESOLFT, which is partly based on STED principles, is a super resolution imaging strategy that allows for high-speed imaging of nano-scale events where the resolution of conventional confocal microscopy techniques fail. Using this approach, Testa and colleagues have been able to visualize plastic remodeling in the dendritic spine followed over seconds-hours. Dr. Testa was recently recruited as a principal investigator to SciLife Lab where her laboratory will use super resolution microscopy techniques to address the synaptic basis for plasticity in the nervous system.