5-NITRO-ortho-TOLUIDINE
(Group 3)

5. Summary of Data Reported and Evaluation

5.1 Exposure data

5-Nitro-ortho-toluidine is used as an intermediate in the
production of a wide assortment of pigments and azo dyes. No data
on occupational exposure levels were available.

5.2 Experimental carcinogenicity data

5-Nitro-ortho-toluidine was tested for carcinogenicity
by oral administration in one strain of mice and in one strain
of rats. It produced an increase in the incidence of hepatocellular
tumours in mice of each sex and a marginal increase in the incidence
of hepatocellular carcinomas in male rats.

5.3 Human carcinogenicity data

No data were available to the Working Group.

5.4 Other relevant data

5-Nitro-ortho-toluidine was mutagenic to bacteria in the
presence and absence of an exogenous metabolic system.

5.5 Evaluation

There is limited evidence for the carcinogenicity of 5-nitro-ortho-toluidine
in experimental animals.

No data were available from studies in humans on the carcinogenicity
of 5-nitro-ortho-toluidine.

Overall evaluation

5-Nitro-ortho-toluidine is not classifiable as to its
carcinogenicity to humans (Group 3).