SwissProt ID

Gene ID

Ncbi ID

Available reactivities

Hu (Human), Ms (Mouse)

Available hosts

Rabbit

Available applications

Western blot / Immunoblot (WB)

Background of PLD6 antibody

PLD6 is a cardiolipin hydrolase present at the mitochondrial outer membrane required both for mitochondrial fusion and piR metabolic process. PLD6 acts by catalyzing the hydrolysis of cardiolipin (diphosphatidylglycerol) to form phosphatidate (phosphatidic acid or PA) at the mitochondrial outer membrane surface, promoting mitochondrial fusion. The production of phosphatidate also regulates the piR metabolic process by promoting recruitment and/or activation of components of the meiotic nuage, also med P granule, a critical step for primary biogenesis of piRs. It is required during spermatogenesis to repress transposable elements and prevent their mobilization via its role in the piR metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRs and Piwi proteins and govern the methylation and subsequent repression of transposons.