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Abstract

(a) Purpose To determine what areas of hyperenchancement and hypoenhancement on multi-detector CT (MDCT) represent in terms of infarct size and myocardial regional blood flow (RBF), and the effect of nitrite on RBF and MDCT contrast patterns.

(c) Results There was a correlation between infarct area on CT and that defined by TTC (r2=0.75). There was a poor correlation between MVO on CT and MVO by TSE (r2=0.46). TTC and TSE identified distinct differences in flow within R (1.2 ± 0.19 ml/min/g), I (0.62 ± 0.11 ml/min/g), and MVO (0.3 ± 0.04 ml/min/g) areas, respectively. Despite increased RBF in remote (+45%) and MVO (+80 %) regions in nitrite group compared to saline, there was no corresponding change in MDCT contrast patterns. Two animals died in each group.

(d) Conclusion MDCT is a reliable predictor of infarct size but not microvascular obstruction at 24 hours post infarction. Sodium nitrite increased RBF to MVO regions, but this was not detected by MDCT.