The potential of RSN to detect the
early change of neuronal networks induced by short-term cognitive intervention was
investigated by using a verbal training task to read short sentences aloud
everyday for 4 weeks. Twenty community dwelling older adults participated in
this study. Activation in the anterior SN was decreased after the training, suggesting
optimization of salience processing to integrate visual information and language
production. The SN may be potentially a biomarker to firstly reflect the change
in response to cognitive interventions in older adults and this finding may be
applied to optimize training protocols for each individual.

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