IHPE – DESTOUMIEUX-GARZON Delphine english

POSITION: Researcher CNRSRESPONSIBILITIES : – Head of the team MIMM- Co-organizer of the symposium AMP2016

SCIENTIFIC SOCIAL NETWORKS : (click on the logo)

RESEARCH – EXPERTISE AREA:
From 1995 to 2000, my research has focused on the role of antimicrobial peptides (AMPs) in the innate immunity of vertebrates and invertebrates. As a graduate student (Bachère lab, University of Montpellier, France) and then as a post-doctoral fellow (Ganz lab, UCLA, USA), I have characterized the structure and expression of diverse AMP families (e.g. penaeidins, b-defensins). Hired as a permanent researcher at the CNRS in 2000, I have studied the role of AMPs in microbial competitions and characterized AMP biosynthetic pathways, structures and modes of action with a particular interest in the hijacking of iron uptake systems. Since 2006, I have focused my research on the molecular interplay between hosts and microorganisms using the oyster-vibrio interaction as a model. One central question I am addressing is what makes the oyster pathogens and commensals able to circumvent their host antimicrobial response. With that goal, I am exploring oyster/vibrio interactions from their diversity to the mechanisms sustaining their infectious success (colonization and immune evasion). The role of the environment in the emergence/selection of those adaptive traits and in the transmission of vibrios to oysters is also part of my current scientific interests. Those projects are developed at different scales (molecule, cell, organism, and ecosystem) in close collaboration with colleagues from the MIMM team and diverse French and European laboratories (Frédérique le Roux, Sun Wai, Melanie Blokesch…).

AWARDS :
– Researcher of the Future for the Languedoc Roussillon Region in 2009