Clinical manifestations and molecular diagnosis of scrub typhus and murine typhus Vietnam, 2015-2017TrungN. V.auteurautHoiL.auteurautDienV. M.auteurautHuongD. T.auteurautHoaT. M.auteurautLienV. N.auteurautLuanV.auteurautLewyckaS. O.auteurautChoisyMarcauteurautIRDBryantJ. E.auteurautNadjmB.auteurautVan DoornH. R.auteurautRichardsA. L.auteurautVan KinhN.auteurauttextjournalArticleengtext/pdfreformatted digitalaccessRickettsioses are endemic to Vietnam; however, only a limited number of clinical studies have been performed on these vectorborne bacteria. We conducted a prospective hospital-based study at 2 national referral hospitals in Hanoi to describe the clinical characteristics of scrub typhus and murine typhus in northern Vietnam and to assess the diagnostic applicability of quantitative real-time PCR assays to diagnose rickettsia' diseases. We enrolled 302 patients with acute undifferentiated fever and clinically suspected rickettsiosis during March 2015-March 2017. We used a standardized case report form to collect clinical information and laboratory results at the time of admission and during treatment. We confirmed scrub typhus in 103 (34.1%) patients and murine typhus in 12 (3.3%) patients. These results highlight the need for increased emphasis on training for healthcare providers for earlier recognition, prevention, and treatment of rickettsial diseases in Vietnam.specializedVIET NAM052 050 080 Emerging Infectious Diseases25463364120191080-6040http://www.documentation.ird.fr/hor/fdi:01007548310.3201/eid2504.180691Centre IRD de BondyF B010075483http://www.documentation.ird.fr/hor/fdi:010075483http://horizon.documentation.ird.fr/exl-doc/pleins_textes/divers19-04/010075483.pdfIRD - Base Horizon / Pleins textes2019-05-132019-05-13fdi:010075483fre