Drug Repurposing to Identify Therapeutics Against COVID 19 with SARS-Cov-2 Spike Glycoprotein and Main Protease as Targets: An in Silico Study

The
total cases of novel corona virus (SARS-CoV-2)
infections is more than one million and total deaths recorded is more than fifty thousand.
The research for developing vaccines and drugs against SARS-CoV-2 is going on in different parts of the world. Aim
of the present study was
to identify
potential drug
candidates against
SARS-CoV-2 from existing drugs using in silico molecular modeling and
docking. The targets for the present study was the spike
protein and the main
protease of SARS-CoV-2. The study was able to identify some drugs that can either bind to the spike protein receptor
binding domain or the main protease of SARS-CoV-2. These include some of the antiviral drugs. These
drugs might have the potential
to inhibit the infection and viral replication.