[Ryuji Igarashi] Development of nanodiamond bioimaging for three-dimensional structural dynamics

Presto Researcher

Ryuji Igarashi

Japan Science and Technology Agency
PRESTO Researcher

Outline

In order to understand the functions and characteristics of individual cells, it is essential to three-dimensionally visualize structural changes of intracellular biomolecules responsible for various biological activities. In this study, I will establish a fundamental bioimaging techniqe to visualize the 3D dynamics of intracellular biomolecules based on our previously developed “optically-detected magnetic resonance microscope” and molecular targeting approachs utilizing fluorescent nanodiamonds. Our bioimaging technique could be a breakthrough to uncover how mechanical/thermal signal is sensed by cells and transduced into cellular signaling pathways.