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Paris: Big-serving American John Isner stunned Roger Federer to reach the quarter-finals of the Paris Masters on Thursday.
Isner won 7-6 (7/3), 3-6, 7-6 (7/5) for just his second career win over the Swiss legend.
Federer, who won the tournament for the only time in 2011, dropped an opening set tie-break 7/3 before battling back with three games in a row to win the second 6-3.
The deciding set again saw serves on top with Federer failing to convert a rare break point at 3-3.
He then twice served successfully to stay in the match to force another tie-break.
Isner took a 4-1 lead after Federer netted an overhead backhand smash and a backhand into the net from the 17-time major tournament winner handed the giant American four match points.
He converted the last of those for the biggest upset so far in the tournament.
Isner will play David Ferrer for a semi-final spot after the Spanish eighth seed outlasted Grigor Dimitrov of Bulgaria 6-7 (4/7), 6-1, 6-4 in another third round tie.

London: Murray will next face Belgian David Goffin who he could come up against later in November in the Davis Cup final. Murray broke Coric in the second game of the first set to assert his authority early on in the match.
The number two seed then held serve for a second time to move into a commanding 3-0 lead.
Murray continued to dominate the set and went on to win it in comfortable fashion by a 6-1 scoreline.
The second set went with serve until the fifth game when Murray broke again before holding to lead 4-2.
Another break of serve in game seven set Murray up for victory which he secured by serving out for a 6-1 6-2 success in 58 minutes.
Goffin meanwhile dropped only one game more in beating Serbian qualifier Dusan Lajovic 6-2 6-2.
There was no place in the next round for Murray's fellow Briton Aljaz Bedene who lost in straight sets to American John Isner.
The number 13 seed beat Bedene, a qualifier, was able to cruise through the first set before winning a tie-break in the second to clinch a 6-3 7-6 (7/3) success.Meanwhile third seed Roger Federer effortlessly moved into the third round with a 6-1 6-1 victory against Andreas Seppi.

Basel: Old rivals Roger Federer and Rafael Nadal posted straight-sets wins at the Swiss Indoors on Saturday to line up their first final against each other since Rome in 2013.
Spaniard reached the final of the Swiss Indoor tournament when he beat Frenchman Richard Gasquet 6-4 7-6(7) on Saturday.
Gasquet could still have denied Ferrer a place in the ATP World Tour Finals next month, but his defeat means Ferrer, along with Japan's Kei Nishikori, complete the eight-man line-up for the season-ending showpiece.
Nadal was a break down in the opening set but hit back from 2-4 to win four consecutive games.
He also trailed 6-4 in the second-set tiebreak before reeling off the last four points.
Federer is looking for a seventh title in his home city.
Ferrer and Nishikori join three-times defending champion and 2008 winner Novak Djokovic, Andy Murray, six-times former winner Federer, Stan Wawrinka, Tomas Berdych and Nadal in London.

Mexico City: Nico Rosberg set the fastest time for Mercedes in Mexican Grand Prix practice on Friday as large crowds welcomed Formula One back to the country after a 23-year absence.
The German, who is fighting for second place in a championship already won by team mate Lewis Hamilton, lapped the Hermanos Rodriguez circuit with a best of one minute 21.531 seconds.
Red Bull`s Daniil Kvyat and Daniel Ricciardo were second and third on the timesheets with rain falling later in the afternoon.
Toro Rosso`s Max Verstappen, who was not even born last time Formula One raced in Mexico in 1992, brought out red flags with a crash at the final corner in the afternoon after setting the pace in the morning session.
The 18-year-old Dutch driver was still the youngest driver to top a Formula One practice session with a best effort of 1:25.990.
He appeared to cut a corner on the Esses sequence in doing so, however.
Russian Kvyat, born two years after Britain`s Nigel Mansell won the 1992 race, was also second fastest in the morning.
Hamilton, who took his third world championship and 10th win of the season in Texas, was 11th and fourth fastest respectively.
Rosberg, chasing Ferrari`s Sebastian Vettel for second with three races remaining, was sixth before lunch when his car`s rear brakes overheated. The German headed back to the pits with flaming wheels.
Vettel was fourth in the morning and then fifth fastest.
Mercedes have also won the constructors` championship, leaving Sunday`s race with nothing to play for other than the race win and precious points for those further down the standings.
The high-altitude circuit, much revamped from the old one with the daunting Peraltada curve now cut in half, has one of the longest straights on the calendar and Friday`s start to practice was in damp conditions.
Spectators queued outside from early on, amid a heavy police presence and the usual traffic gridlock, to get a glimpse of the cars and home favourite Sergio Perez.
Mexico`s only current Formula One driver, who is likely to be joined on the grid by Esteban Gutierrez next season with new team Haas making an announcement later, was ninth and 15th fastest in the sessions.

London: The chemistry between Murray brothers is fabulous in Davis Cup, but their mother admits the pair squabbled regularly as youngsters.
They have proven that they are successful double partners by winning semi final against Australia, . But the duo did not have such a harmonious relationship during their childhood and mother Judy has joked how the pair's fierce competitive nature often led to physical clashes.
She told CNN's Open Court show: "It didn't matter what it was; cards, dominoes, monopoly, golf or football, they were always competing with each other.
"They had a lot of fun as well as a lot of fighting. They made up their own games and they made up their own scoring systems and their own rules.
Andy Murray celebrates with his brother Jamie as they beat Lleyton Hewitt and Sam Groth of Australia
"I can't say they even played or trained a lot of tennis together because they didn't manage to last half an hour without fighting with each other!"
Both Murrays have forged successful careers as Andy is currently ranked at No 3 in the world with two Grand Slam trophies to his name, while Jamie also possesses a major title after winning the Wimbledon mixed doubles in 2007 and reached this year's men's doubles final at the US Open.
The siblings played in the same singles tournaments in their younger years and Judy recalls a fiery post-match exchange between the pair.
"The story that always springs to mind was when they played against each other at a tennis tournament," she said. "I had taken a lot of children down from Scotland. I'm driving back in the mini-bus, it's quite dark and Andy has beaten Jamie in the final of this U12 event.
"They start having a fight in the back of the mini bus. Andy's hand is over the back seat and eventually Jamie has taken enough and nails his fist into Andy's hand. The two brothers passionately support each other's careers
"There was blood and I had to stop the bus, we dress the wound, separate them and drive the few hours back.
"We had to take Andy for a tetanus shot because the nail was ripped and the nail has never grown in straight. But it's a reminder about being humble and never bragging about beating anyone, especially your brother!"
But Andy is hugely supportive of Jamie, often watching him from the stands and sends out congratulatory messages on social media.
"Jamie is without question Andy's number one fan," said Judy. "They are the only people I think of who can really say what they are thinking straight to each other's face. There are not that many people who can do this, particularly with Andy nowadays."

Rio de Janeiro: Spanish tennis player Rafael Nadal said that he will play in February's Rio Open on his 'favourite' clay surface. The 14-time Grand Slam winner won the inaugural edition of the ATP 500 event in 2014 before being eliminated by Italy's Fabio Fognini in the semifinals of this year's tournament.
"The Rio Open is an important event on the tennis calendar in a special country," the 29-year-old said in a statement on Thursday.
"I have developed a great relationship with the Brazilian public over the last two years and I love going back there," Nadal said.
Nadal endured a frustrating 2015, failing to win a Grand Slam for the first time in a calendar year since 2004.
The 2016 Rio Open will be played at the Brazilian Jockey Club from February 15 to 21.

London: Andy Murray has a good chance to end the year at No. 2 for the first time. But he says that while that would be a good achievement, getting to No. 1 is a more significant goal.
Novak Djokovic is currently No. 1 and is almost 6,000 points ahead of No. 2 Murray. Even if Djokovic happens to decline, it will still take Murray months to catch him and pass him.
Murray has been able to climb to No. 2 during the course of seasons, but the two-time Grand Slam champion was never able to finish the year second.
“All of the players on the tour would like to get to No. 1 in the world,” said Murray, who lost to Djokovic in the semifinals of Shanghai. “Obviously this year I have a good chance to finish at No. 2, which would be the first time for me.
"There are still a lot of possibilities where I could finish at maybe even No. 4, or whatever, if Stan (Wawrinka, who is currently No. 4) plays extremely well between now and the end of the year, and Roger as well. Look, the goal is to try to win tournaments, try and win the big events. If you do that, the ranking will go in the right direction."
Murray is currently about 1,100 points in front of Federer and is leading Wawrinka by 1,700 points.
Of the so-called Big 4, Djokovic, Federer and Rafael Nadal have become No. 1, and have stayed there for a long period of time. However, Great Britain's Murray has yet to do so.
But he knows what is required to get to the top of the rankings.
“This year, although I'm a long way behind Novak in the rankings, a few matches can change that significantly,” Murray said. “Grand Slam semifinals and finals, they're the matches that are for big, big points. That's something, if I want to get to No. 1 in the world, need to win a couple more of them. So hopefully next year I'll be able to do that.”

New Delhi: The all-conquering Indo-Swiss pair of Sania Mirza and Martina Hingis added another trophy in its collection after winning a hard-fought China Open final match on Saturday.
Starting as the favourites to win the women's doubles title in Beijing, they beat Chan sisters from Chinese Taipei, Hao-ching and Yung-jan in three grueling sets, which lasted an hour and 40 minutes.
The US Open champions lost the first set in the tie-breaker 11-9, but returned strongly in the second set to win 6-1. Then, in an epic deciding third set, the experienced duo won 10-8.
In the previous three meetings, the Chan sisters had won a match against the top-ranked doubles team.
This is the eighth title for the Mirza-Hingis pair of the year, having already won the Indian Wells, Miami, Charleston, Wimbledon, US Open, Guangzhou abd Wuhan titles. Besides, the pair also registered an impressive 46-7 win-loss record for the year till date.