Earlier this year, 2 trial studies to test the efficacy and safety of exercise training among patients with Chronic Heart failure were published in the Journal of the American Medical Association (JAMA). This study randomized 2,331 stable systolic heart failure patients to placebo vs. exercise and followed them for 30 months. The exercise group underwent 36 sessions in 3 months of supervised aerobic exercise training (walking, treadmill or stationary bicycle), 15-30min at 60-70% HR reserve (max HR on ETT minus resting HR) TIW followed by home-based training 5x/wk of 40min at 70% HR reserve. The study concluded that regular exercise training in patients with systolic heart failure was not only safe, but supported in addition to evidence-based therapy. Patients following a prescribed exercise program showed statistically significant improvements in self-reported health status plus reduction in hospitalization and all-cause mortality, and modest increases in health-related quality of life. While we know that testosterone & human growth hormone (hGH) can also improve chronic heart failure outcomes, exercise is a safe part of any Cenegenics-Carolinas regimen for patients with chronic heart failure. Read the full article in JAMA.