Status

Abstract

Keywords

sincope, pathophysiology, tilt table testing, treatment

Summary

The theses consists of 144 pages, which begins with an introduction, followed by 4
chapters, conclusions, practical recommendations, bibliography from 176 sources, 9 annexe, 16
tables and 18 figures. The obtained results are published in the 13 scientific works.

Domain of research: cardiology.

Goal of research: Elucidation of some physiopathologic mechanisms in neurocardiogenic
syncope and improvement of methods of diagnosis and treatment.

Objectives of research: To study the possibility of enhancing the diagnostic value of the
tilt table testing and the implication of both nitric oxide and catechilamines in the vasodilation
mediation in patients with either neurocardiogenic syncope or syncope with unidentified genesis.
To analyse the efficiency of the treatment based on such drugs as propranolol and fluoxetin,
administered to patients with neurocardiogenic syncope. To survey the importance of the serumal
concentration of the adrenaline during syncope in order to establish the efficiency of the treatment
with propranolol.

Methodology of research: Within the framework of the research the following methods
have been used: investigation, tilt table testing, laboratory analysis, statistical, monitoring.
Novelty and originality of research:It is the first clinical study which has appreciated the
serumal fluctuation of the nitric oxide concentration in patients with marked neurocardiogenic
syncope and syncope with unidentified genesis, reccuring during the tilt table testing. There has been
studied the possibility of increasing the diagnostic value of the test through a successive carrying on
of different variants of this diagnostic method.

Theoretical value and applied value: The involvement of catecholamines and nitric
oxide in the occurrence of neurally mediated syncope has been confirmed. It has been
established that it is unreasonable to use the tilt table testing in assessing the efficiency of the
drug-based prolonged treatment in patients with neurocardiogenic syncope.

Practical implementation: The result of the study were estimated as scientific work and
later implemented in current curative activity of the Institute of the Cardiology and chair of
cardiology of SMPhU ,,Nicolae TestemiŃanu,,.

Oficial Reviewers

Valeriu Revencodoctor habilitat, professor, Nicolae Testemitanu State University of Medicine and Pharmacy of the Republic of Moldova

Victor Vovcdoctor habilitat, professor, Nicolae Testemitanu State University of Medicine and Pharmacy of the Republic of Moldova