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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

For example, using mutant mice with reducedexpression of SOD-2, Wenzel and colleagues demonstrated an increased oxidative stress with disrupted vascular function in these animals in relation to cardiac disease [34].

Moreover, overexpression of SOD-2 in the Tg2576 mice reduced the levels of phospho-eNOS back to those in wild-type mice (Figure 2), which corresponded with the recovered blood flow deficits in these same mice.

This increase was recovered back to wildtype levels upon SOD-2overexpression, suggesting that mitochondrial superoxide contributes to tau pathology not only in the olfactory bulb, but also extends to the learning and memory centers of the brain.

In conclusion, the results of the present study provide evidence that bladder apoptosis induced by AUR after acute BOO and subsequent bladder emptying is associated with decreasedMnSODexpression, increased PARP activity and imbalance between pro- and anti-apoptotic factors.

Another important finding was that bladderapoptosis induced by AUR after acute BOO and subsequent bladder emptying was associated with decreasedMnSODexpression, increased PARP activity and imbalance between proand anti-apoptotic factors.

These results indicate that downregulation of MnSODexpression and imbalance of Bcl-2 family proteins expression play a critical role in the development of bladderapoptosis following AUR and subsequent reperfusion.