Adolescent substance use disorders have far-reaching social and economic ramifications. The trend toward early onset of substance use disorders has increasingly resulted in adolescents who enter treatment with greater developmental deficits along with other high risk needs. This workshop will target cross-systems coordination of care for substance-using adolescents and review methods for utilizing data-driven decision-making tools to enhance coordination of screening, assessment, and referral for substance use problems among adolescents involved in various systems of care.