There are major teachings in theses natural products that we would do well to consider. They may be reflecting eons of wisdom and refinement. … In fact, one of the most promising approaches in diversity chemistry is to produce diversity-chemistry-derived collections that benefit from partake of the “wisdom” of natural products. - Samuel J. Danishefsky

Natural chemistry does occupy chemical space distinct from bioactive molecules and common organic molecules. What is more, natural product structures differ depending on the organism or natural source they have come from. Based on the presented cheminformatics analysis, TimTec NDL includes the same scaffolds that are produced by plants, animals, and bacteria:

NDL-3000 is a “natural” extension of the well-known NPL-800, Pure Natural Product Library, in design and structural diversity. Compounds comply with screening purity standards. NDL-3000 is available as an entire collection or in custom subsets. Custom formatting is available in vials or 96/384 plates. NPL and NDL are independent screening collections and make a good screening pair for nature inspired chemistry exploration.

Natural Products in Journal of Medicinal Chemistry

One of the topical Miniperspectives from the Journal of Medicinal Chemistry examines the benefit of coupling natural products chemistry and synthetic organic chemistry: "A combination of natural products chemistry and focused library synthesis furnishes a powerful tool for drug discovery."

The paramount importance of nature-sourced and nature-inspired products in drug discovery is proverbial. Statistics keeps natural products and their derivatives research relevant: combinatorial chemistry produced only one FDA-approved drug for the last 20 years compared to 57.7% of approvals for natural-products-based drugs.

At the same time evolution in combinatorial chemistry, parallel synthesis, computational chemistry, and molecular target-based drug discovery accumulated valuable methods and tools that can be applied to natural material.