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In Vivo Dynamics of Cyclic AMP Signaling in CNS

The candidate sought will have expertise in current methods of brain surgery (drug administration, light guide and GRIN lens cannulae implanation), light microscopy (two-photon and standard confocal), and molecular biology (design, construction and deployment of viral vectors for gene delivery to CNS), or related skills, aptitude and interest, to participate in studies to understand the roles of neuropeptide and catecholamine signaling through NCS-Rapgef2 (see Jiang et al., eNeuro 4(5) e0248-17.2017 1-17, 2017) in stress-induced relapse to psychomotor stimulant addiction; sex steroid regulation of aversive behavior; and neuroplasticity mediated through changes in intracellular signaling and dendritic spine dynamics. Position location is Building 49 Room 5A-27 and 5A-35 and adjacent microscopic and animal facilities in Building 10A and the Porter Neuroscience Center, NIH Campus, Bethesda Maryland.

Qualifications:

Those required to complete experiments using the techniques mentioned in Description of work, or assurance that those aspects of technical proficiency required can be rapidly acquired via instruction from local highly-qualified staff.

To Apply:

Please send CV, contact information for references, and letter of intent to Lee Eiden, eidenlmail.nih.gov. It would be helpful to describe briefly how you might wish to contribute to exploring the role of NCS-Rapgef2 as a major cAMP effector in catecholamine and neuropeptide signaling in the central nervous system as initially described by Jiang et al., NCS-Rapgef2, the Protein Product of the Neuronal Rapgef2 Gene, Is a Specific Activator of D1 Dopamine Receptor-Dependent ERK Phosphorylation in Mouse Brain eNeuro 4(5) e0248-17.2017 1-17, 2017.

The NIH is dedicated to building a diverse community in its training and employment programs. The NIMH, and this investigator, are particularly committed to mentoring the careers of talented scientists from currently underrepresented groups among our scientific community.