Species

oxyquinoline

Summary

Summary: An antiseptic with mild fungistatic, bacteriostatic, anthelmintic, and amebicidal action. It is also used as a reagent and metal chelator, as a carrier for radio-indium for diagnostic purposes, and its halogenated derivatives are used in addition as topical anti-infective agents and oral antiamebics.

..Radioactive labelling with (111)In-oxine has been used in preclinical trials. This study aimed to validate (111)In-oxine labelling and subsequent in vivo and ex vivo detection of haematopoietic progenitor cells...

..Here we demonstrate that glycoconjugates are cleaved in vitro by β-glucosidase and these systems exhibit antiproliferative activity against different tumor cell lines in the presence of copper(II) ions...

8-Hydroxyquinoline as a building block for artificial receptors: binding preferences in the recognition of glycopyranosides

..Taken together, these results suggest that 8HQ acts to inhibit inflammation through inhibition of NO production and iNOS expression through blockade of C/EBPbeta DNA-binding activity and NF-kappaB activation...

..No effects on DNA secondary structure could be observed in an electrophoretic mobility shift assay using double-stranded plasmid DNA. Thus, further studies on the therapeutic applicability of KP46 in malignant melanoma are warranted...

..This can be attributed to the fact that the water solubility of Cu(OX)(2) is enhanced by the presence of HA. Thus, we conclude that HA has a potential for use as an amendment for the ER of hydrophobic chemicals, such as Cu(OX)(2)...

Early results from a phase I study on orally administered tris(8-quinolinolato)gallium(III) (FFC11, KP46) in patients with solid tumors--a CESAR study (Central European Society for Anticancer Drug Research--EWIV)

..Bacterial mutagenicity tests have not been shown to predict in vivo effects of 8OHQ; these assays are similarly expected to be poorly predictive of in vivo genotoxic and carcinogenic potential of AlQ...

..It was demonstrated that 1H VFMAS SSNMR spectra accumulated for 20 nmol of the polycrystalline samples in 10 min enabled one to distinguish alpha- and beta-forms of Cu(II)(8-quinolinol)2 on the basis of shift positions and line widths...

..This study assessed the therapeutic significance of lipid-soluble compounds of (111)In, which passively diffuse through the cell membrane, bind to cytoplasmic components, and remain cell bound until decay...

..Because intravenous administration of MSCs results in significant lung activity that obscures the assessment of myocardial cell trafficking, alternative routes of administration should be investigated for this application...

Selective oxidation of methane by the bis(mu-oxo)dicopper core stabilized on ZSM-5 and mordenite zeolites

..Amorphous alumina nanotubes were obtained after removing the GaQ3 by dissolving in toluene or by heat treatment at 350 degrees C. The amorphous nanotubes could be crystallized by heating at 900 degrees C for 1 h in vacuum...

Noninvasive in vivo imaging of monocyte trafficking to atherosclerotic lesions

..I introduced our studies of In-WBC in aortic aneurysma and aortic dissection. The In-WBC maybe useful for detection of inflammation of the aortic aneurysma and evaluation of prognosis of aortic dissection...

Optimization of dispersive liquid-liquid microextraction of copper (II) by atomic absorption spectrometry as its oxinate chelate: application to determination of copper in different water samples

Marie T DinhSection of Infectious Diseases, Department of Medicine, University of Wisconsin School of Medicine and Public Health, MadisonClin Infect Dis 47:519-27. 2008

..45, 2.84, 24.36, 2.10, and 10.07, respectively. The presence of exposed bone or a positive probe-to-bone test result is moderately predictive of osteomyelitis. MRI is the most accurate imaging test for diagnosis of osteomyelitis...

PET with FDG-labeled leukocytes versus scintigraphy with 111In-oxine-labeled leukocytes for detection of infection

..Although it is known that RBC concentrates may contain buffy coat and platelet concentrates may contain platelet aggregates, the circulation and distribution of these materials in the blood products have never been reported...

..This sensing material could be used in the field to visually determine metal cation concentrations in drinking water. A color chart would be used to relate the diffracted color to the metal cation concentration...

..A correlation coefficient of 0.98 was obtained. The proposed method could be used for routine analysis in clinical laboratories for accurate determination of aluminum in aqueous or biological fluids...

..986 for dilutions up to 1:20. This method combined with sensitive methods for the quantification of L-Asn will allow bioequivalence studies and individualized therapeutic drug monitoring of different ASNASE preparations...

Delayed hyperresistance of endothelial cells to photodynamic inactivation after contact with hemin

..To evaluate three previously unreported substrates for the detection of beta-glucosidase activity in clinically relevant bacteria and to compare their performance with a range of known substrates in an agar medium...

Synthesis and biological activities of new substituted thiazoline-quinoline derivatives

..Moreover, ulcerogenicity and the median lethal dose (LD(50)) of the most active anti-inflammatory compounds 6b and 9e were determined in mice; they were non-toxic at doses up to 400 mg kg(-1) after i.p. administration...

Adsorption of hydroxy pyridines and quinolines at the metal oxide-water interface: role of tautomeric equilibrium

..The anti-43 kDa antibodies reacted strongly with the 55-60 kDa protein. Based on these results, it appears that the 60 kDa glycoprotein in brain synaptic membranes described in the present study is the same protein as the cloned pGlyBP...

..While SbCl(3) proved to be cytotoxic against HL-60 cells, it was not active against Jurkat cells. However, its coordination to the quinoline derivatives resulted in complexes with significant cytotoxicity against Jurkat cells...

Synthesis, characterization and evaluation of ionic-imprinted polymers for solid-phase extraction of nickel from seawater

..heterophylla L. genome. The genomic instability associated with polyploidy may be the result of selection shaped by environmental adaptations and/or human-induced manipulation through agricultural practices...

Redox properties of 8-quinolinol and implications for its mode of action

..However, significantly more mastitis isolates were able to grow in the presence of the cefixime-tellurite supplement. 8-Hydroxyquinoline-beta-D-glucuronide is a useful substrate for the identification of STEC O157 on SMAC...

..The protective properties of the sol-gel films were improved by the addition of HAP, proving their applicability as submicrometer-sized reservoirs of corrosion inhibitors for active anticorrosion coatings...

Research Grants16

..A successful agent will be highly useful invention not only for early detection of but also for following disease progression and as biomarker for assessing disease-modifying treatments for Alzheimer's disease. ..

..We will begin our studies using indium-111 platelets in human disease with a reassessment of the role of the spleen in idiopathic (immune) thrombocytopenic purpura and of platelet kinetics in patients with homocystinuria...

..The analyte sensing will be monitored by using a simple Palm Pilot-type instrument that utilizes a color CCD camera. The results could be immediately displayed, and easily recorded if the device is operated as a patient biographer. ..

..Because the MRI techniques developed in these studies will be readily adaptable to clinical studies, the proposed research could have a significant impact on patient care in ischemic heart disease. ..