Neurological conditions could begin in the womb

Researchers say a protein usually associated with the immune system could play a role in the development of neurological conditions such as epilepsy and schizophrenia.

University of Queensland lecturer and medical alumnus Dr Liam Coulthard led the study into how brain development is affected by altering the activity of the complement system – which controls innate or natural immunity – during pregnancy.

“Our research in mouse models has shown neural defects can result when this system is functioning inappropriately in utero,” Dr Coulthard said.

“We blocked a key complement component, called C5a, for three days during pregnancy, and this resulted in behavioural abnormalities in the offspring.

“Our research demonstrates this complement factor is essential for the proper development of the brain and has a broader role in addition to its function in the immune system.”