STRING allows inspection of the interaction evidence for any given network. Choose any of the viewers above (disabled if not applicable in your network).

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:query proteins and first shell of interactors

white nodes:second shell of interactors

Node Content

empty nodes:proteins of unknown 3D structure

filled nodes:some 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

IL1098

TPR-containg protein (402 aa)

Predicted Functional Partners:

ccmH

Cytochrome c-type biogenesis protein CcmH (153 aa)

0.995

ccmF

Cytochrome c biogenesis factor (651 aa)

0.993

dsbE

Disulfide isomerase (182 aa)

0.984

ccmE

Cytochrome C biogenesis protein CcmE; Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (160 aa)

0.983

ccmB

Cytochrome C biogenesis ABC transporter permease; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (227 aa)

0.978

ccmA

Cytochrome C biogenesis ABC transporter ATPase; Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (218 aa)

a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1

node2

node1 accession

node2 accession

node1 annotation

node2 annotation

score

IL1098

IL1108

IL1098

IL1108

TPR-containg protein

FlhB domain-containing protein

0.671

IL1098

ccmA

IL1098

IL1106

TPR-containg protein

Cytochrome C biogenesis ABC transporter ATPase; Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system

0.976

IL1098

ccmB

IL1098

IL1105

TPR-containg protein

Cytochrome C biogenesis ABC transporter permease; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes

0.978

IL1098

ccmC

IL1098

IL1104

TPR-containg protein

Cytochrome C biogenesis ABC transporter permease

0.975

IL1098

ccmD

IL1098

IL1103

TPR-containg protein

Heme exporter protein D

0.891

IL1098

ccmE

IL1098

IL1102

TPR-containg protein

Cytochrome C biogenesis protein CcmE; Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH

0.983

IL1098

ccmF

IL1098

IL1101

TPR-containg protein

Cytochrome c biogenesis factor

0.993

IL1098

ccmH

IL1098

IL1099

TPR-containg protein

Cytochrome c-type biogenesis protein CcmH

0.995

IL1098

dsbE

IL1098

IL1100

TPR-containg protein

Disulfide isomerase

0.984

IL1098

vacJ

IL1098

IL1097

TPR-containg protein

Surface lipoprotein

0.887

IL1108

IL1098

IL1108

IL1098

FlhB domain-containing protein

TPR-containg protein

0.671

IL1108

ccmA

IL1108

IL1106

FlhB domain-containing protein

Cytochrome C biogenesis ABC transporter ATPase; Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system

0.763

IL1108

ccmB

IL1108

IL1105

FlhB domain-containing protein

Cytochrome C biogenesis ABC transporter permease; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes

0.763

IL1108

ccmC

IL1108

IL1104

FlhB domain-containing protein

Cytochrome C biogenesis ABC transporter permease

0.755

IL1108

ccmD

IL1108

IL1103

FlhB domain-containing protein

Heme exporter protein D

0.645

IL1108

ccmE

IL1108

IL1102

FlhB domain-containing protein

Cytochrome C biogenesis protein CcmE; Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH

0.730

IL1108

ccmF

IL1108

IL1101

FlhB domain-containing protein

Cytochrome c biogenesis factor

0.674

IL1108

ccmH

IL1108

IL1099

FlhB domain-containing protein

Cytochrome c-type biogenesis protein CcmH

0.672

IL1108

dsbE

IL1108

IL1100

FlhB domain-containing protein

Disulfide isomerase

0.674

IL1108

vacJ

IL1108

IL1097

FlhB domain-containing protein

Surface lipoprotein

0.652

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Network Stats

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Functional enrichments in your networkNote: some enrichments may be expected here (why?)

Enrichment analysis is still ongoing, please wait ...

Statistical background

For the above enrichment analysis, the following statistical background is assumed: