The dentate gyrus is also one of the few regions of the brain where neurogenesis takes place. Neurogenesis is thought to play a role in the formation of new memories. It has also been found to be increased in response to both antidepressants and physical exercise. This implies that neurogenesis may improve symptoms of depression.

The dentate gyrus plays a role in recognizing the differences that make each place unique. Thus, damage to the dentate gyrus can play a role in déjà vu.[1]