The mechanisms involved in the formation of enduring memories are still largely unknown. Lesburguères et al. (see the Perspective by Sweatt) investigated the hippocampal-cortical dialogue during memory consolidation. Neurons in the rat orbitofrontal cortex appeared to be “tagged” at the time of initial encoding, even though the initial learning was hippocampal. Inactivating the orbitofrontal cortex at the time of encoding affected late memory while not affecting memory during the period when it was still supported by the hippocampus.