Tomei also opened up about what she thinks sets Spider-Man apart from other superheroes. "I think that the Spider-Man in general, the origin story, does have a purpose because it's a local hero," the Oscar winner noted. "He's almost a community activist with super powers."

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Tom Holland portrays Tomei's nephew, Peter Parker (a.k.a. Spider-Man), and spoke to ET about what it means to be taking on such an iconic role. "I'm losing my mind right now," the 21-year-old star said of the star-studded premiere. "This is so surreal. My whole like, last three years has been leading up to this moment and we're here today and I can't believe it. I genuinely can't believe it."