Applications of Nuclear Magnetic Resonance to the Study of Myocardial Metabolism and Pharmacology

Abstract

Since the first volume of this series appeared in 1971 with James Fisher’s discussion of the application of nuclear magnetic resonance (NMR) relaxation measurements to the investigation of the binding of small molecules to proteins, instrumental sensitivity and experimental techniques have improved tremendously. In 1974, high-resolution NMR spectra were obtained from phosphate-containing metabolites in whole muscle (Hoult et al., 1974). In subsequent years, many reports of metabolic studies using perfused organs and whole animals appeared. The area has been extensively reviewed (Gadian, 1982; Gadian and Radda, 1981; Gadian et al., 1980; Radda and Seeley, 1979; Garlick and Radda, 1979; Shulman et al, 1979; Burt et al., 1979; Hollis, 1979).