Microsome

microsome

[′mī·krə‚sōm]

(cell and molecular biology)

A fragment of the endoplasmic reticulum.

A minute granule of protoplasm.

Microsome

a fragment in the endoplasmic network (bubbles about 1,000 angstroms diameter), formed when cells are destroyed during the homogenization of animal and plant tissues. The microsome fraction of the homogenate is isolated by differential centrifugation. There are two types of microsomes: smooth-surfaced and rough-surfaced (as a result of the distribution of ribosomes on the latter). Before the technique of separating cellular homogenates was perfected, the microsome fraction also included mitochondria.

Celsis IVT has "purpose-pooled" InVitroCYPs to meet a variety of research needs by using a proprietary technology in which microsome activity levels are optimized across nine key CYP substrates for their respective assay applications.

The effects of Danshen and its active components (tanshinone I, tanshinone IIA, dihydrotanshinone and cryptotanshinone) on CYP2D6 activity was investigated by measuring the metabolism of a model CYP2D6 probe substrate, dextromethorphan to dextrorphan in human pooled liver microsomes.

SRL (100 [micro]g/L) was incubated with individually prepared human liver microsomes (HLM) (n = 31) (donor characteristics are given in Table 1 in the Data Supplement that accompanies the online version of this report at http://www.

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