The paternal genes are almost all sequestered in the mitochondria from those of the mother. Old knowledge. The most important kowledge regarding mitochondria, is the discovery of QBS Constitution dependent, Inherited Real Risks, Nature PG ignore, obviously. For instance:

Despite these medical advances, born 20 years ago, the authoritative Nature is delighted with edited genomes and similar arcadian entertainments. A question: “Nature Editors know their personal risks of getting sick of CVD, T2DM, Cancro, maybe thanks to liquid biopsies?”

(READER FEEDBACK) Here’s How Long You Can Safely Keep Eating Your Thanksgiving Leftovers

Data:

Mon, 26 Nov 2018 16:41:54 +0100

Mittente:

Sergio Stagnaro <dottsergio@semeioticabiofisica.it>

A:

editors@time.com

Dear Time Editors,

unfortunately, you ignore that all humans aren’t born equal. False! Overlooking Constitutiond-Dependent Inherited Real Risks, even TIME lies, rests, languishes in the Middle Ages of Medicine. As a consequence, I’m afraid particularly about your family members, to whom I sugget, with all my heart, Reconstructing Mitochondrial Quantum Therapy, as efficient Pre-Primary and Primary Prevention, according to Quantum Biophysical Semeiotic:

My 63-year-long, well established clinical experience allows me to state that often the differential diagnosis between benign and malignant pulmonary node is very difficult, despite the XR, TAC, NMR of the thorax. Therefore, the updated physical semeiotic can provide a decisive contribution (1-3).

Up-dating physician’s physical semeiotic improves in the best way also the stewardship of antibiotics in the community. Based on a 63-year-long clinical experience, I state that an effective and successful strategy, aimed at the optimal prescription of antibiotics, includes clear communication of a non-bacterial diagnosis, lack of benefit of antibiotics, potential harms of antibiotics, and providing nonantibiotic prescriptions for symptom management. Therefore, the Quantum Biophysical Semeiotic has to be spread among physicians. The knowledge of Reticulum-Endothelial System Hyperfunction Syndrome, complete, incomplete, intermediate, the Acute Anti-body-poiesis Syndrome Activation of the adrenal glands, Terziani’s Manovra, Mancada’s Maneuver, Di Perri’s Maneuver, Domenichini’s Sign, Daneri’s a.s.o. are the basis of the new physical semeiotic, as far as, infectious diseses are concerned.

The relation between heritable mitochondrial impairment and CVD,T2DM, and Cancer.

Posted by Stagnaro on 15 Nov 2018 at 08:06 GMT

Since about 40 years I have discovered a singular mitocondrial cytopathy, and termed it Congenital Acidosic Enzyme-Metabolic Histangiopathy, enlightening the relation with CVD, T2DM, and Cancer (1-3). In addition, from the clinical wiew point, really interesting are the relative Constitution-Dependent, Inherited Real Risks, discovered later, i.e., 20 years ago (4, 5)
As a consequence, I agree with the data of this fascinating papers, corroborating from clinical view-point the statement “we posit that individuals with specific mtDNA variations may differentially metabolise carbohydrates which has implications for a variety of diseases including cardiovascular disease, obesity, and perhaps Parkinson’s Disease”.

I agree with the statement that one of the reasons for the visual–functional mismatch is that myocardial ischemia can be affected by the supplied myocardial size, which is not always evident by coronary angiography. But there is another more important overlooked reason, that is enlightening the poor efficacy of coronary angiography. This method is obviously used late in the presence of symptoms of insufficient blood supply to the myocardium. Fortunately since 20 years physicians can bedsidediagnose quantitatively the CAD Inherited Real Risk, eliminating it with inexpensive Reconstructing Mitocondrial Quantum Therapy.
References
1. Stagnaro Sergio. Role of Coronary Endoarterial Blocking Devices in Myocardial Preconditioning – c007i. Lecture, V Virtual International Congress of Cardiology, 2007. http://www.fac.org.ar/qcv…
2. Stagnaro Sergio. Bedside Evaluation of CAD biophysical-semeiotic inherited real risk under NIR-LED treatment. EMLA Congress, Laser Helsinki August 23-24, 2008. “Photodiagnosis and photodynamic therapy”, Elsevier, Vol. 5 suppl 1 august 2008 issn 1572-1000.
3. Sergio Stagnaro and Simone Caramel. The Key Role of Vasa Vasorum Inherited Remodeling in QBS Microcirculatory Theory of Atherosclerosis. Frontiers in Epigenomics and Epigenetics. http://www.frontiersin.or… [MEDLINE]
4. Sergio Stagnaro and Simone Caramel. The Inherited Real Risk of Coronary Artery Disease, Nature PG., EJCN, European Journal Clinical Nature PG., EJCN, European Journal Clinical Nutrition, Nature PG., http://www.nature.com/ejc… [MEDLINE]

There is a general agreement that cytosolic and nuclear proteins containing iron-sulphur clusters (Fe-S) are essential for the survival of every extant eukaryotic cell. The biogenesis of Fe-S clusters and their insertion into proteins is accomplished through the cytosolic iron-sulphur protein assembly (CIA) machinery. However, CIA is forming Fe-S clusters starting from a mitochondrial substance provided bu mitochondra, till now scarsely Known, the so-called X- substance (correspondence with Prof. Rolland Lill).
Interestingly, an outstanding question is the way by which the CIA machinery directs and inserts newly formed Fe-S clusters into proteins. Not everyone knows that nowadays Quantum Biophysical Semeiotic allows physicians to evaluate using a common stethoscopy the glycocalix, which can provide information on the structure and function of mit-DNA and n-DNA (1-5). As a consequence, if glycocalix is normal, also CIA machinery directs and inserts regularly newly formed Fe-S clusters into proteins.
References.
1) Simone Caramel and Sergio Stagnaro The role of glycocalyx in QBS diagnosis of Di Bella’s Oncological Terrain – http://www.sisbq.org/uplo…
2) Simone Caramel and Sergio Stagnaro Quantum Biophysical Semeiotics of Oncological Inherited Real Risk of Myelopathy: The diagnostic role of glycocalyx. http://www.sisbq.org/uplo…
3) Sergio Stagnaro. Glycocalix Quantum-Biophysical-Semeiotic Evaluation plays a Central Role in Demonstration of Water Memory-Information. www.sisbq.org. 19 July, 2011.http://www.sisbq.org/uploads/5/6/8/7/5687930/wmi_glycocalyx.pdf
4) Sergio Stagnaro and Simone Caramel (2011). Skeletal Muscle Cell Glycocalix Evaluation during CFS Treatment corroborates Andras Pellionisz’s Recursive Fractal Genome Function Principle. http://www.sisbq.org/uplo…
5) Sergio Stagnaro and Simone Caramel (2011). The genetic Reversibility in Oncology, Journal of Quantum Biophysical Semeiotics, http://www.sisbq.org/uplo…

Pre Primary Prevention of Brain disorders: a promising original strategy in the future Medicine.

Posted by Stagnaro on 25 Oct 2018 at 09:24 GMT

People with psychosocial disabilities are growing on over the world. Among the important unresolved questions relating to psychosocial disabilities, there is one, really paramount, escaped US scholars and politicians. Before starting pregnancy, physicians must exclude in the young women the presence of predisposition to brain disorders with the medical examination. Beside a flurry number of Brain disorder Inherited Real Risks, removed by Reconstructing Mitochondrial Quantum Therapy, the cerebellum is a reliable sensor of all future cerebropathies (1-5). In doing so, we cut at the root the problems, CRPD activity is based on.

Notoriously, ovarian cancer kills approximately 15.000 women in the United States every year, and more than 140,000 women worldwide. Most deaths from ovarian cancer are caused by tumours of the serous histological type, which are rarely diagnosed before the cancer has spread (1).
In a long, well-established, clinical experience, Quantum Biophysical Semeiotics proved to be reliable and useful tool also in early bedside detecting ovarian cancer, since its first stage, i.e., Oncological Terrain-Dependent, Inherited Real Risk, unfortunately mainly overlooked by physicians around the world (1-3).
In healthy woman, lying down on supine position, psycho-physically relaxed, and with open eyes to reduce endogenous melatonin secretion, lasting intense (1,000 dyne/cm.2) digital pressure on X thoracic dermatomere , at the lower region of right or left iliac fossa, i.e., ovarian trigger-points, brings about aspecific gastric reflex (= stomach fundus and body dilate, while antral-pyloric region contracts), after a latency time of exactly 8 sec.
The reflex lasts physiologically more than 3 sec. and less than 4 sec., due to local microcirculatory reason, showing the efficacy of Microcirculatory Functional Reserve, that is a really a paramount parameter value, since it parallels fractal dimension of related microvessell fluctuations, analized as ureteral reflex oscillation, more difficult to assess.
On the contrary, in any Inherited Real Risk of ovarian cancer, latency time is still the same, i.e. 8 sec. (NN = 8 sec.), but reflex duration interestingly lasts 4 sec. or more (NN > 3 < 4 sec.), in relation to severity of underlying disorder. Interestingly, after the reflex the stomach contracts pathologically, showing an intense local tissue acidosis: tonic Gastric Contraction (tGC), typical fo cancer, starting from the very initial stage at birth..
These parameter values (Explicate Order, according to D. Bohm) are based od ovarian microcirculatory abnormalities (Implicate Order), I have termed microcirculatory remodelling, characterised by newborn-pathological, type I, subtype a), oncological, Endoarteriolar Blocking Devices (3). More precisely speaking, reflex latency time becomes shorter than the normal 8 sec. in inverse relation to the tumour stage, initiatting when the heritable risk becomed activated, that is the true beginning of the oncogenesis. Moreover, in day-to-day practice, biophysical semeiotic ovarian preconditioning is very useful and reliable: exactly 5 sec. after the basal, initial manoeuvre, when ovarian Microcirculatory Functional Reserve is activated by digital pressure, doctor performs the above described test a second time.
In health, where Tonic Gastric Contraction is always absent, theLatency Time raises in a clear-cut manner, doubling its basal value: second latency time increases to 16 sec.
On the contrary, in ovarian cancer, even in its Inherited Real Risk, Latency Time either persists unchanged or increases not significantly in relation to the severity of ovarian cancer stage.
Importantly, latency time lowers significantly in case of overt ovarian cancer, since initial stages of its evolution.
Such a sign, easy to perform and reliable at the bed-side, is really useful in both ovarian cancer clinical diagnosis, among a large variety of other remarkable biophysical-semeiotic signs. In addition, as I described previously (2-5), malignancies occur on the base of a genetically transmitted mitochondrial cytopathology, I named Congenital Acidosic Enzyme-Metabolic Histangiopathy, conditio sine qua non of Oncological Terrain (1-5). These inherited abnormalities of psycho-neuro-endocrine-immunological system is mainly transmitted by mother’s mitochondria. Therefore, it is non-sense, or at least uselessly expensive, for instance, to ask if patient’s mother is, or was, involved by ovarian cancer, as well as assess oncological biomarkers and newly discovered mutated genes level in women without Oncological Terrain and/or whatever Cancer Inherited Real Risk.
All Inherited Real Risks are removed by Reconstructing Mitochondrial Quantum Therapy (5).
References

I find Philip E. Bourne argumentations extremely important. However, let’s consider that, despite about 33.000 peer-reviews, publishing montly millions of articles of oustanding Oncologists, CVD, T2DM, Osteoporosis, and Cancer are till now growing epidemics.Not only Medicine progress but also the current war against these disorders are to be ameliorated. For instance, the fight against cancer is based falsely on screening, i.e. secondary prevention, and a scarsely efficient but expensive treatment, as the growing epidemic of cancer demostrates. The Fake News worry Editors and Oncologists, who continue however to ignore the effective, inexpensive, realizable rationally on very large scale, even in undeveloped and developing Countries, Pre-primary and Primary Prevention of cancer, according to Quantum Biophysical Semeiotic (1-3). In additon, informing doctors with little expense is a goal to be achieved. I would like to ask to all professors, mentioned in the Editorial, if they know their possible Oncological Terrain-Dependent, Inherited Real Risk as well as Reconstructing Mitochondrial Quantum Therapy (5). Overlooking the above-mentioned progress of Medicine in general and of Oncology in particular, accounts for the reason we must offer these advancements via Internet, free, as International Society of Quantum Biophysical Semeiotic does since ever. Unfortunately, of the two sides of the Medicine coin – pre-primary and primary prevention and cancer therapy – oncologists know strangely only the second.

Physicians skilled in Quantum Biophysical Semeiotic (QBS) are able to bedside evaluate with a common stethoscope in quantitative way a flurry of signs in Tubercolosis as well as in all other infective disorders. The most important signs are the complete Reticulo-Endotelial System Hyperfuction Syndrome, RESHS, (only in the flu viroses RESHS is incomplete: the spleen does’nt augment its antibody production) , more precise and specific than ESR , Acute Antibody Synthesis, PCR, Microcirculatory Activation of Adrenal glands, a.s.o. (1-5). As a consequence, accurate prediction of susceptibility to first-line Tuberculosis drugs is possible at the bedside, through the QBS evaluation of the positive modifications of numerous signs mentioned above.

Alzheimer Disease Inherited Real Risk plays a central Role in its Pre-Primary and Primary Prevention.

Posted by Stagnaro on 26 Sep 2018 at 14:39 GMT

Calcium-antagonists can slow moderate and mild forms of Alzheimer’s disease (AD), improving brain microcirculation. As a matter of facts, Quantum Biophysical Semeiotics is able to make since birth the diagnosis of AD Inherited Real Risk (1-5) and of numerous brain disorders, http://www.plosone.org/ar…. Easily, through the Auscultatory Percussion of th stomach, digital pressure of the typical areas of Alzheimer disease, i.e., pre-frontal areas, limbic region, this original semeiotic can reveal if any subject, from the moment of birth, is at risk of such disorder.
There are two main QBS tests usefull in bedside diagnosing AD since birth: the test of microcirculatory activation of the above-mentioned areas of brain, and the insulin secretion acute peak test. Furthermore, there is a Quantum Entanglement Sign, which can reveal the Inherited Real Risk of brain disorder, specially related to Alzheimer disease.
Alzheimer Disease is not reversible by medical treatments, and the current research is concentrated just on genetic and histological clinical tests, while QBS is able for the first time to provide for such disorder a biological evaluation, because biological system functional modification parallels gene mutation. Furthermore QBS is able to make a diagnosis of AD not only at the first very initial stages, usually very difficult to do, but even many years before that such disease could appear, allowing so an efficacious primary prevention, according to the Manuel’s Story.
References.
1) Stagnaro Sergio. Alzheimer’s Disease Byophysical Semeiotics supports the pathophysiology of Koudinov’s theory.11 January 2002. Clin. Med. & Health Research http://clinmed.netprints….
2) Simone Caramel and Sergio Stagnaro. Clinical QBS Diagnosis and Primary Prevention of Brain Disorder ‘Inherited Real Risk’ and Alzheimer Disease. Journal of Quantum Biophysical Semeiotics. 5 August, 2011. http://www.sisbq.org/uplo…
3) Marco Marchionni, Simone Caramel, Sergio Stagnaro. Inherited Real Risk of Alzheimer’s Disease: bedside diagnosis and primary prevention.Frontiers in Neuroscience, in http://www.frontiersin.or…
4) Marco Marchionni, Simone Caramel, Sergio Stagnaro. The Role of ‘Modified Mediterranean Diet’ and Quantum Therapy In Alzheimer’s Disease Primary Prevention. Letter to the Editor, The Journal of Nutrition, Health & Aging, Volume 18, Number 1, 2014, Springer Ed. http://link.springer.com/… [Medline]
5) Sergio Stagnaro. Il Segno di Scopinaro: un pizzicotto cutaneo permette in 3 secondi di fare la Diagnosi Differenziale tra Malattia di Alzheimer e Demenza Senile.http://www.sisbq.org/uplo…

Dear PLoS friends,
my previoius comment has been cancelled because it was no politically correct? Here it’s: “Musella’s Sign in bedside detecting Lung Cancer starting from its Oncological Terrain, Dependent Inherited Real Risk.
Posted by Stagnaro on 19 Feb 2018 at 15:42 GMT
Musella’s Sign, http://www.sisbq.org/uplo… allows physician to bedside detecting with a common stethoscope the Lung Cancer starting from birth, namely from its Oncological Terrain, Dependent, Inherited Real Risk. Intense digital pressure (1,000 dyne/cm.2), applied on any skin projection are of the lung, due to no-local reality in biological systems, brings about simultaneously the aspecifc gastric reflex (in the stomach, fundus and body dilate, while antral-pyloric region contracts), followed immediately by typical tonic gastric contraction”.
If the facts are these, I will not send more comments. Keep calm.

No competing interests declared.

__________ _________________ ______________

Bedside Primary Prevention of Lung Cancer must replace screening.

I recently wrote in PLosMedicine web-site, http://journals.plos.org/… that bedside Primary Prevention of Lung Cancer, using a common stethoscope, is far better than the screening. As a matter of facts, a 63-year-long clinical experience allows me to state that Baserga’s variant Sign (1-5) is the best method to stop the growing epidemic of lung cancer, allowing physicians to recognize from birth lung cancer Inherited Real Risk, removed by inexpensive Reconstructing Mitochoondrial Quantum Therapy (5). This original sign is based on the stimulation of sternal bone marrow, brought about by erythropoietin-like substance, secreted by malignat cell, even in its first stage, i.e., Inherited Real Risk.

Bedside Primary Prevention of Lung Cancer must replace screening.

CANCELLED due to Reference

I recently wrote in PLosMedicine web-site, http://journals.plos.org/… that bedside Primary Prevention of Lung Cancer, using a common stethoscope, is far better than the screening. As a matter of facts, a 63-year-long clinical experience allows me to state that Baserga’s variant Sign (1-5) is the best method to stop the growing epidemic of lung cancer, allowing physicians to recognize from birth lung cancer Inherited Real Risk, removed by inexpensive Reconstructing Mitochoondrial Quantum Therapy (5). This original sign is based on the stimulation of sternal bone marrow, brought about by erythropoietin-like substance, secreted by malignat cell, even in its first stage, i.e., Inherited Real Risk.

The comprehension of the pathogenesis of epilepsy finds a new impulse in studies on nonlinear dynamics of EEG signals and in the growing genetic molecular evidence of the mitochondrial origin of this disease. These data are consistent with the information registered bedside by Quantum Biophysical Semeiotics that clinically investigates microcirculation, both on a functional
viewpoint (by studying deterministic chaotic dynamics) and on a structural viewpoint (1, 2). Microcirculatory dysfunctions reflect those of a genetically altered mit-DNA and of a functional mitochondrial cytopathy, known as Congenital Acidosic Enzyme-Metabolic Histangiopathy, originating from this mutation and which is particularly intense both in patients with epilepsy
and in those with an Inherited Real Risk of epilepsy (2). Preclinical diagnosis of an Inherited Real Risk of epilepsy allows physicians to finely select subjects with a predisposition to this disease since birth in order to perform an efficient pre-primary and primary prevention.
References.
1) Marco Marchionni, Simone Caramel, Sergio Stagnaro. QBS Inherited Real Risk of epilepsy: physiopathology, diagnosis and primary prevention – 2014. Journal of QBS, http://www.sisbq.org/uploads/5/6/8/7/5687930/iirrofepilepsy.pdf
2) Marco Marchionni, Simone Caramel, Sergio Stagnaro. Integrated Quantum Therapy in an Epileptic Child after 13 Years of Inherited Real Risk of Epilepsy in Evolution: A Case Study. NeuroQuantology, Vol 14, No 2 (2016)
3) Caramel S., Marchionni M., Stagnaro S. Morinda citrifolia Plays a Central Role in the Primary Prevention of Mitochondrial-dependent Degenerative Disorders. Asian Pac J Cancer Prev. 2015;16(4):1675. http://www.ncbi.nlm.nih.gov/pubmed/25743850 [MEDLINE]

The comprehension of the pathogenesis of epilepsy finds a new impulse in studies on nonlinear dynamics of EEG signals and in the growing genetic molecular evidence of the mitochondrial origin of this disease. These data are consistent with the information registered bedside by Quantum Biophysical Semeiotics that clinically investigates microcirculation, both on a functional
viewpoint (by studying deterministic chaotic dynamics) and on a structural viewpoint (1, 2). Microcirculatory dysfunctions reflect those of a genetically altered mit-DNA and of a functional mitochondrial cytopathy, known as Congenital Acidosic Enzyme-Metabolic Histangiopathy, originating from this mutation and which is particularly intense both in patients with epilepsy
and in those with an Inherited Real Risk of epilepsy (2). Preclinical diagnosis of an Inherited Real Risk of epilepsy allows physicians to finely select subjects with a predisposition to this disease since birth in order to perform an efficient pre-primary and primary prevention.
References.
1) Marco Marchionni, Simone Caramel, Sergio Stagnaro. QBS Inherited Real Risk of epilepsy: physiopathology, diagnosis and primary prevention – 2014. Journal of QBS, http://www.sisbq.org/uploads/5/6/8/7/5687930/iirrofepilepsy.pdf
2) Marco Marchionni, Simone Caramel, Sergio Stagnaro. Integrated Quantum Therapy in an Epileptic Child after 13 Years of Inherited Real Risk of Epilepsy in Evolution: A Case Study. NeuroQuantology, Vol 14, No 2 (2016)
3) Caramel S., Marchionni M., Stagnaro S. Morinda citrifolia Plays a Central Role in the Primary Prevention of Mitochondrial-dependent Degenerative Disorders. Asian Pac J Cancer Prev. 2015;16(4):1675. http://www.ncbi.nlm.nih.gov/pubmed/25743850 [MEDLINE]

The early bedside diagnosis of lung cancer, starting from its first stage of Inherited Real Risk, I’ve termed the Sign of Musella, https://sergiostagnaro.wo… -musella-the-silence-of-professors-and-different-from-my /, would save thousands of lives (1-3).
Moreover, such a diagnostic weapon would also facilitate the clinical in differential diagnosing between benign and malignant nodes of the lung, avoiding the present and distressing psychological terrorism.
References
tentare di falsificarlo?

As in all diseases, especially if they are incurable, primary prevention is the best therapy. I can not believe, but it’s true unfortunately, that the majorety of Editors and Aathors worldly ignore till now the Inherited Real Risk of Alzheimer’s Disease (1-4) as well as that the cerebellum is a sensor of the future senile Dementia (5). On these two realities,i.e., two facts, is founded my overlooked clinical fight against the AD and the Brain ATS, with or without senile Dementia, Interestingly, as all other Inherited Real Risks, of CVD/CAD, T2DM, Osteoporosis, Cancer, a.s.o., AD Inherited Real Risk can be bedside diagnosed from birth with a common stethoscope and removed by inexpensive, personalizad Reconstructing Mitochondrial Quantum Therapy, (6).
1) Stagnaro Sergio. Alzheimer’s Disease Byophysical Semeiotics supports the pathophysiology of Koudinov’s theory.11 January 2002. Clin. Med. & Health Research http://clinmed.netprints….
2) Simone Caramel and Sergio Stagnaro. Clinical QBS Diagnosis and Primary Prevention of Brain Disorder ‘Inherited Real Risk’ and Alzheimer Disease. Journal of Quantum Biophysical Semeiotics. 5 August, 2011. http://www.sisbq.org/uplo…
3) Marco Marchionni, Simone Caramel, Sergio Stagnaro. Inherited Real Risk of Alzheimer’s Disease: bedside diagnosis and primary prevention.Frontiers in Neuroscience, in http://www.frontiersin.or…
4) Marco Marchionni, Simone Caramel, Sergio Stagnaro. The Role of ‘Modified Mediterranean Diet’ and Quantum Therapy In Alzheimer’s Disease Primary Prevention. Letter to the Editor, The Journal of Nutrition, Health & Aging, Volume 18, Number 1, 2014, Springer Ed. http://link.springer.com/… [Medline]

The cerebellum is from birth the brain’s ATS sensor with and without dementia.

In a previous paper I have described and illustrated patho-physiological mechanisms that accounts for the reason the cerebellum is from birth the brain’s ATS sensor with and without dementia (1). The bedside microcirculatory evaluation in the middle-anterior part of the cerebellum, allows the physician to diagnose the above-mentioned Inherited Real Risk, dependent on ATS Constitution (2). Unfortunately, such a paper is in Italian. I hope the discovery will interest my colleagues and someone will translate it into English. With the inexpensive therapy Reconstructing Mitochondrial Quantum Therapy (3), the physician eliminates the heritable predisposition to atherosclerosis of the brain, that notoriously brings about serious damage to families. Interestingly, all mothers, even apparently healthy, of patients involved by brain ATS, are positive for this heritable risk

All around the world children are vaccinated till now without knowing their Inherited Real Risks, for example, of Autism (ASD), Rett syndrome, Hunter syndrome, a.s.o (1-4). Thanks to Quantum Biophysical Semeiotic, physicians can bedside recognize all the heritable risks in the envolved mothers (100%) and eliminate them with Reconstructing Mitochondrial Quantum Therapy (5), before the onset of pregnancy or in children immediately after birth. I think, to achieve significant, momentous goals in pre-primary and primary prevention not always researchers, regardless of theit countries, need funds. Despite the resources obtained, the researchers, have not been able to stop today’s growing epidemics of CVD, T2DM, and Cancer especially because of overlooking related Inherited Real Risks and how removing them.
As a matter of facts, the discovery without any cost of CVD/CAD, T2DM, and Cancer Inherited Real Risks, recognized from individual’s birth with a common stethoscope and removed by not expensive therapy (5) did not bring still great success. The explanation of this distressing event deserves an urgent explanation, in my opinion. Speaking frankly, I do not think that today famous PGs of peer-reviews, as PLoS, can spread knowledge of Medicine that belong to 2050. Let us think that, according to the present Weltanschauung of Medicine, the water of human body (approximately about 80 percent of the brain total weight) is stationary, rather than vibrating in a coherent way! In addition, among physicians and Editors, nobody knows that it does really exist non-local realm in biological system beside the local one (www.sisbq.org). Interestingly, to bedside recognize in one second cancerous areas (Cancer Inherited Real Risk) of all biological systems, although very limited, physicians could use firstly Terziani’s Maneuver, so that in a few minutes, they would be able to bedside recognize the individuals affected by cancer, a long time before diseases symptomatology occurs.
References.
1) Sergio Stagnaro and Simone Caramel. BRCA-1 and BRCA-2 mutation bedside detection and breast cancer clinical primary prevention. Front. Genet. | doi: 10.3389/fgene.2013.00039. http://www.frontiersin.or… [MEDLINE]
2) Sergio Stagnaro and Simone Caramel. The Key Role of Vasa Vasorum Inherited Remodeling in QBS Microcirculatory Theory of Atherosclerosis. Frontiers in Epigenomics and Epigenetics. http://www.frontiersin.or… [MEDLINE]
3) Sergio Stagnaro and Simone Caramel. Inherited Real Risk of Type 2 Diabetes Mellitus: bedside diagnosis, pathophysiology and primary prevention. Frontiers in Endocrinology,. 2013; 4: 17. http://www.frontiersin.or… [Medline]
4) Sergio Stagnaro and Simone Caramel. The Inherited Real Risk of Coronary Artery Disease, Nature PG., EJCN, European Journal Clinical Nutrition, Front Endocrinol (Lausanne). 2013; 4: 17. Published online 2013 Feb 26. doi: 10.3389/fendo.2013.00017[Medline]
5) Caramel S., Marchionni M., Stagnaro S. Morinda citrifolia Plays a Central Role in the Primary Prevention of Mitochondrial-dependent Degenerative Disorders. Asian Pac J Cancer Prev. 2015;16(4):1675. http://www.ncbi.nlm.nih.g…[MEDLINE]

The essential problem in the protection of subjects against CAD and AMI is to enrich the physical examination with the search for Caotino’s Sign, which allows physician to recognize at the bed-side the Inherited Real Risk of CAD, with or without predisposition to myocardial infarction, using a common stethoscope (1-3).

In my opinion, to preventing the most common and deadly disorders in both underdeveloped and developed countries, competent health Authorities must take into account the central role played by the Pre-Primary and Primary Prevention of the most common and dangerous human pathologies, which depends clearly by easy and quick bed-side detecting individuals involved by relative Constitution-Dependent, Inherited Real Risks, e.g., of CVD/CAD, T2DM, Cancer (1-4).

In order to define clinically a particular constitution, which does not exclude the presence of other ones, it is necessary to think over the current possibility of gathering at the bed-side biophysical-semeiotic data, rich of biological and molecular-biological information on the various human organs, tissues and apparatus, so that doctor can describe numerous types of constitutions, even from the quantitative point of view. Without any doubt, these data cannot be observed at all by the aid of traditional physic semeiotics, unable of carrying molecular-biological events to clinical dimension, which really represents the most original and fertile aspect of Quantum Biophysical Semeiotics (5). Not to speak, obviously, of sophysticated semeiotics, expensive and unable to be applied on large scale. I am sure that it represents a new medical “Weltanschauung”, which, therefore, needs open-minded physicians at the “peer-reviews”, nowadays, unfortunately, very seldom to be find.

For a long time, due to technical problems regarding my Username and Password, I have been trying to comment papers, published on PLOS journals, with your HELP. Do you remember, don’t you? Finally, I succeded in sending my comments (Attachment).
Surprisingly, I realize thal all my comments are cancelled without reason after some days.
I admitt my English is poor, but I cannot imagine that also PLOS Editors accept and publish only comments politically correct.Never mind! I will survive even without sending you further cricitics.
I thank you in any case because you highlight and explain what accounts for the reason CVD/CAD, T2DM, Osteoporosis and Cancer are growing epidemics.

Without CVD Inherited Real Risk, the numerous environmental risk factors of ATS are innocent bystanders (1-5). As a consequnce, the Authors have to enrolle in this type of research exclusively diabetics, involved by CVD Inherited Real Risk. As a matter of facts, only a percentage of T2DM shows artery disorder, atherosclerotic in nature, but not all.

In my opinion, if ATS Constitution-Dependent, Inherited Real Risk really exists (1-4), and it is not the same as the diabetic (5), the data of this research are fundamentally biased. As a matter of facts not all diabetics are suffering for CVD. Aiming to assess properly risks and population burden of Cardiovascular Diseases Associated with Diabetes the Authors have to enroll in their research exclusively diabetics involved also by ATS Constitution-Dependent, Inherited Real Risk.

Early bedside diagnosis of pancreas cancer is easy

The best of all therapies is notoriously Primary Prevention.
There is a general agreement among the Authors around the world that Pancreas Cancer diagnosis, especially in initial, symptomless stages, first of all, Inherited Real Risk, is really difficult, if possible. Notoriously such a malignancy is known as “the silent killer”.
I suggest you to PLOS Editors to write an Editorial on this topic, which will be really interesting.
Despite my poor English, I can provide them with pleasure my technical support, whose scientific value is surely of paramount level, as demonstrates the mail of Scientific Committee of Marseille Symposium, 2014, I can send them if they want it.

CANCELLED

The best way to do a research

Despite a flurry of paramount researches, performed in famous Universities and National Institutes, CVD, T2DM, Osteoporosis and Cancer are today’s growing epidemics. There is something grossly wrong in the current way of conducting researches and describing their data. For instance, there is a general agreement among the Authors worldwide that pancreas cancer diagnosis, especially in its symptomless stages, is very difficult, if possible, in the course of decades, when therapeutic results would be surely better. As a consequence, such a cancer has been termed as “the silent killer”. On the contrary, bedside pancreas cancer is really easy for the physicians skilled in Quantum Biophysical Semeiotic, starting from its Inherited Real Risk. In my opinion, it’s tragic that these studies, although useful to humankind, cannot be published on the famous peer-reviews, spreading widely among doctors.

Mitochondria dysfunction are essential in the pathogenesis of both T2DM and Parkinson’s Inherited Real Risk (1-%)
Quantum Biophysical Semeiotic (QBS) theory offers an approach “as a whole” of the patho-physiology of inherited mitochondrial neurodegenerative diseases, as well as that of PD, characterized by an Inherited Real Risk (IRR) of Brain Disorders (3,4). In the frame of QBS theory, the combination of Clinical Microangiology and “Angiobiopathy” theory (1), allows to merge the hypothesis of PD as neurological microvascular-based disease and the researches focused on mitochondrial dysfunction according to the inherited genetic causes of this neurodegenerative pathology, i.e., the congenital alteration of mit-DNA in related neuronal cells. QBS is a new discipline in medical field and an extension of the classical medical semeiotics with the support of quantum and complexity theories. It is a scientific trans-disciplinary approach that is based on the “Congenital Acidosic Enzyme-Metabolic Histangiopathy” (CAEMH) (1-5), a unique mitochondrial cytopathy that is present at birth and subject to medical therapy. The presence of intense CAEMH in a well-defined area (i.e., pre-Rolandic area) is due to gene mutations in both n-DNA and mit-DNA. This is the basis for one or more QBS constitutions, which could bring about their respective IRR (1-5).
The Quantum BS method allows the clinical and pre-clinical diagnosis of the most severe diseases such as the IRR of brain disorders including PD; this is achieved in the easier way through the auscultatory percussion of the stomach . Made with the aid of gastric aspecific reflex, this diagnosis is consistent and dually reflects the informative nature and quality of parameters collected by QBS microcirculatory investigations. The patho-physiology of QBS reflexes is based upon local microvascular conditions. In case of genetic alteration of both DNAs, intense CAEMH, and IRR of Brain Disorders there is a microcirculatory remodeling, especially intense under environmental risk factors, due to vasomotility and vasomotion impairment (e.g., functional imperfection) and structural obstructions, i.e., pathological Endoarteriolar Blocking Devices (EBDs) and Arteriovenous Anastomosis (AVA) (Stagnaro, 2009c). According to QBS, most of these inherited impairments are already present, in a similar form, in micro-vascular neurobiological systems and clinically observable since birth, through ureteral reflexes diagnosis. Briefly, in healthy, from the microcirculatory point of view, during stress test both vasomotility (chaotic-deterministic oscillations of arterioles) and vasomotility (chaotic deterministic fluctuations of nutritional capillaries and post-capillary venules) are maximally activated, particularly in parietal cerebral regions. On the contrary, in individuals with a family history positive for PD and, of course, in patients in the first stages of AD, under identical conditions a dissociated form of microcirculatory activation appears, characterized by increased vasomotility and decreased vasomotion. The flow- and flux-motion in the cerebral microcirculatory bed appears to be clearly decreased, due to the dangerous phenomenon of the so-called “microcirculatory blood-flow centralization.” Every environmental risk factor has to act upon such a Inherited Real Risk of PD.

Sirs, there is now a general agreement among the Authors around the world that Pancreas Cancer diagnosis, especially in initial, symptomless stages, is really difficult. However, when phisicians will be able to bedside recognize the entire symptomatology of pancreas cancer, including its Oncological Terrain-Dependent, Inherited Real Risk, such a diagnosis will be really easy from individual’s birth. Finally, the inhexpensive Quantum Therapy removes this predisposition to the till now deadly pancreas cancer. (1, 2)

2)Sergio Stagnaro (2015). Thanks to Quantum Biophysical Semeiotics, Stating that the Diagnosis of Pancreas Cancer is difficult, especially in the early, asymptomatic stages , is false since July 3, 2015.https://sergiostagnaro.wo…

Medicine is Maid of Economics. As a consequence, physicians ignore the advances, clinical in nature, among these a central role is played by Quantum Biophysical Semeiotic Constitutions. For instance, tobacco smoking facilitate diabetes onset, but evidently in NOT all individuals, because subjects without such as predisposition will never be involved by diabetes. Analogously, exclusively individuals positive for Oncological Terrain “and” Inherited Real Risk of lung cancer, possibly will suffer for lung cancer, under negative effect of cigarette smoking.

Rossana’s Sign and Manoeuvre* are really interesting especially for the general practitioners, who at the bedside can use the stethoscope only. In reality, no Laboratory and no Image Department are now able to make a diagnosis of Oncological Terrain-Dependent, Inherited Real Risk, starting from the birth of the subject (1).

I have some years ago discovered and described in previous papers how our brain sensor, i.e. PNEI system and Limbic area, including Hippocampus, react to every, even minimal, insult, aiming to damage or to destroy body health, independent of its nature.

In a few words, at Christmas 2011, from womb of Quantum Biophysical Semeiotics (http://www.sisbq.org) has born a new clinical diagnostic method, I have termed Brain Sensor Bedside Evaluation (BSBE), which has opened a new road in the field of physical Semeiotics (2). Physicians have to utilize in daily practice the present knowledge on cerebral cortex functions, as it has recently happened, regarding PNEI system and Limbic region, i.e. Brain Sensor Bedside Evaluation.

In following, I briefly illustrate the Rossana’s Sign and Manoeuvre, reliable in bedside recognizing from the birth, i.e., from Oncological Terrain-Dependent, Inherited Real Risk, lesions oncological in nature. Interestingly, such a clinical method allows physicians to recognize with a stethoscope, easily and quickly, the presence of the heritable, through maternal mitochondria, predisposition to cancer, localize it precisely, staging it and removing it by inexpensive Reconstructing Mitochondrial Quantum Therapy (3-5).

In health, at rest, Hippocampus microcirculatory flow-motion shows physiological wall movements: the diastole of Peripheral Heart, according to Allegra (6, 7), namely, small arteries and arterioles, according to Hammersen, lasts 6 sec. (= vasomotility), paralleling the duration of vasomotion of the local nutritional capillaries: type I, physiological, associated Microcirculation.

On the contrary, in individual involved by any oncological disorder, starting from birth, i.e., from the Oncological Terrain-Dependent, Inherited Real Risk, Hippocampus microcirculation appears activated, of Type 2, dissociated, characterized by prolonged Duration of the only vasomotility, aimed at maintaining the normal value of vasomotion (= 6 sec.): Rossana’s Sign positive.

The intensity of these parameter values parallels the seriousness of underlying disorder, proving to be a useful tool for therapeutic monitoring.

Interestingly, in the overt tumour, intense digital pressure (1,000 dyne/cm2), applied directly either on the lesion, even by means of Psychokinetic Diagnostic (8, 9), or on its trigger-point, brings about simultaneously further Microcirculatory Activation in the Hippocampus, doubling the basal duration of the Latency Time of Hippocampus-Gastric Aspecific Reflex, a value more easy to be evaluated by physicians: Rossana’s Manoeuvre positive.

Interesting from the view-point of lesion staging, in the first stages of cancer, the above reflex pathological events show a less intensity and a delay in the onset during the stimulation, above referred. Latency Time ranging from 2 to 10 sec., in inverse relation to the stage of the disease.

The so-called liquid biopsy is an expression of the onset of a cancer, even silent, highlighting the diagnostic importance of Rossana’s Sign and Manoeuvre.

Before concluding, I would like to mention that the multiple functions of the cerebellum, can now be carefully evaluated at the bedside with a common stethoscope, according to Clinical Microangiology (6, 7). Some years ago, I have suggested the possible existence of a close relationship between the cerebellum and future cerebral atherosclerosis, demonstrating it in clinical research, conducted with the essential psychokinetic diagnostics (8-9).

Such a intuition proved to be correct, since the cerebellum is a sensor of future cerebral degenerative vascular disease, as Senile Dementia, Parkinson Disease, Alzheimer Disease, a.s.o.. Briefly said, I started a clinical research aimed to recognize the possible Inherited Real Risk of all Brain Degenerative Diseases. It is impossible to summarize this complex method. However, the following experimental evidences highlight what I mean.

In health, the mere thought of rotating the head is accompanied by microcirculatory activation type I, associated, physiological, in the cerebellum middle anterior area.

In contrast, in patients involved by overt brain atherosclerosis, between the “thinking” of rotate the head and the cerebellar microcirculatory activation, type II, dissociated, there is a latency time of 3 – 4 seconds, because of the local microcirculatory remodeling, typical of the Inherited Real Risk, removed by inexpensive therapy (4).

In health, the cerebellum microcirculation is normal also in the above mentioned middle anterior area.

However, the very intense pressure (about 1,500 dyne/cm. 2) above any cutaneous projection area of the brain, brings about microcirculatory activation type I, associated, physiological, in the cerebellum middle anterior area.

I had in mind to send you an EDITORIAL on the Rossana’s Manoeuvre (Rossana is my young nephew). As you, Editors of Neurology have always known, the Hippocampus is a sensor of Cancer, solid and liquid, starting from birth, ie from Oncological Terrain-Dependent, Inherited Real Risks. Obviously I’ll publish elsewhere my last scientific discovery.

A suggestion to you all of an old doctor: Treat all epileptics, not only your family members, ALSO with Reconstructing Mitochondrial Quantum Therapy.

Thank you for your Disputes & Debates submission and subsequent revision, on the Neurology® article, “Maternal death in women with epilepsy: Smaller scope studies.” The editors found that your letter was not of sufficient priority for publication.

We read with interest the article on maternal death in women with epilepsy by Christensen et al.1 However, epilepsy can be present only in individuals born from mothers positive for epilepsy-inherited real risk.2 In addition, epilepsy-inherited real risk is generally associated with other serious inherited real risks (e.g., of cardiovascular disease, type 2 diabetes mellitus, and cancer).3–5 All inherited real risks can be bedside diagnosed, even from birth, using a common stethoscope, the constitution-dependent inherited real risks can be definitively removed through reconstructing mitochondrial quantum therapy.6