An Open-Label, Phase I Dose Escalation Trial of TH-302 in Combination with Gemcitabine and Nab-Paclitaxel in Previously Untreated Subjects with Metastatic or Locally Advanced Unresectable Pancreatic Adenocarcinoma

The purpose of this research study is to investigate the safety of the study drug TH-302 in combination with two other chemotherapy drugs in patients with advanced pancreatic cancer who have not been treated before, and to find out the best dose to further test the study drug.