On Sunday, the Buffalo Bills (3-2) will look to secure their fourth consecutive victory against Chip Kelly, Colin Kaepernick and the San Francisco 49ers (1-4). The Bills opened as a seven-point favorite over the 49ers on Monday, but the line has risen to nine points as of Friday, according to OddsShark.com.

Here are six storylines to follow regarding the match up.

Colin Kaepernick to make first start of 2016 against the Bills

On Tuesday, Chip Kelly announced that Colin Kaepernick would be the team’s starting quarterback in place of Blaine Gabbert, who was completely ineffective through five games.

Kaepernick is a physical specimen and his skill set fits everything that Kelly’s offense asks from a quarterback. He’s got a big frame and a strong arm, but it’s his athletic ability that made him a superstar during the team’s Super Bowl runs in 2012-13. He’s dangerous as a runner and presents a variety of issues for opposing defenses.

Both team’s utilize a lot of option concepts both in the run and passing game, so it’ll be interesting to see whether Bills quarterback Tyrod Taylor or Kaepernick will steal the show.

DT Marcell Dareus may miss another game

Defensive tackle Marcell Dareus rejoined the team after serving his four-game suspension, but just two days before the Rams game, he suffered a hamstring injury that kept him on the sidelines.

Things don’t look better for Week 6, as both Dareus and coach Rex Ryan have been vague when discussing his timetable for return. On Friday, Dareus was officially listed as ‘Doubtful’ on the team’s injury report.

“We’ll see how he progresses through the week, because I really don’t know.”

Bills need a win to keep pace with the New England Patriots.

Buffalo needs to come out with a win, as they’re currently second-place in the AFC East, trailing the New England Patriots (4-1) who play the Cincinnati Bengals (2-3) on Sunday.

The Bills need a win just to clear the stench of going eight years without managing to put together a four-game win streak, and the win would put Buffalo at 4-2 before they get a favorable matchup against a divisional opponent on the road in the Miami Dolphins

Will Tyrod Taylor step up and win a game with his arm

Buffalo’s explosive running game has dominated opponents and is the main reason they are riding a three-game win streak. However, quarterback Tyrod Taylor needs to step up and start making things happen in the passing game on a consistent basis. He’s had flashes in every game and has done a good job protecting the football, but he needs to have a bigger impact.

Last week against the Rams in the first half, Taylor was eight-of-13 for 102 yards and a touchdown. In the second half, he was four-of-10 for 22 yards. He will need to show that he can improve on those numbers if the Bills hope to continue their winning streak.

Can the Bills stop RB Carlos Hyde?

While Bills running back LeSean McCoy will present a difficult challenge for the 49ers defense on Sunday, San Francisco running back Carlos Hyde will bring his own set of nightmares for Buffalo defenders.

Hyde has rushed for 377 yards on 95 attempts and is averaging more than 75-yards per game rushing.

The Bills struggled to contain Rams running back Todd Gurley last week, allowing the second-year back to for 72 yards and one touchdown on 23 carries. Gurley also caught three passes for 36 receiving yards as well.

Buffalo will have to do a better job against Hyde if they hope to win the game.

Will Chip Kelly or Anthony Lynn win the battle of option-based schemes?

Both the Bills and 49ers run up-tempo offenses that vary their pace with no-huddle, option-based run-pass schemes that make use of their mobile quarterbacks.

Though this type of scheme is something Kelly has been noted for using in college and the NFL, Buffalo’s newly appointed offensive coordinator Anthony Lynn is a rookie play-caller who inherited his current scheme after Greg Roman was fired after two games.

It will be interesting to see if Lynn’s “patchwork” offensive scheme can outscore Kelly’s legendary high-octane offense.

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