Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )

Length:

98

Sequences:

637

Seq/Len:

6.5

HH_delta:

0.892 (20Jul13)

GREMLIN Results:
Residue pairs sorted by strength in covariance:Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

i

j

Raw Score

Scaled Score

34_G

61_G

0.3631

2.345

20_A

73_A

0.30268

1.954

16_G

80_G

0.29158

1.883

43_A

51_F

0.28455

1.837

38_K

41_E

0.28304

1.828

63_V

66_P

0.2748

1.774

46_E

53_K

0.27243

1.759

35_I

62_A

0.2656

1.715

24_L

73_A

0.25917

1.674

65_K

72_E

0.24217

1.564

47_G

50_G

0.23418

1.512

29_Q

33_S

0.22502

1.453

38_K

57_K

0.21914

1.415

27_G

31_G

0.21553

1.392

34_G

39_P

0.2133

1.377

59_V

63_V

0.20876

1.348

12_D

84_Q

0.20614

1.331

76_K

80_G

0.20456

1.321

60_P

64_V

0.20091

1.297

52_V

70_A

0.19819

1.280

80_G

83_N

0.19635

1.268

50_G

54_G

0.19109

1.234

58_G

61_G

0.19021

1.228

56_G

60_P

0.18563

1.199

33_S

37_A

0.18449

1.191

43_A

47_G

0.18202

1.175

68_I

75_S

0.17419

1.125

39_P

43_A

0.17148

1.107

32_A

62_A

0.17031

1.100

59_V

86_D

0.16945

1.094

21_Y

24_L

0.16486

1.065

15_E

19_Q

0.16396

1.059

19_Q

24_L

0.163

1.053

19_Q

76_K

0.16034

1.035

21_Y

25_G

0.16028

1.035

34_G

62_A

0.1597

1.031

17_L

77_T

0.15839

1.023

42_G

50_G

0.15729

1.016

76_K

79_Q

0.15471

0.999

38_K

68_I

0.15349

0.991

49_K

70_A

0.15226

0.983

77_T

81_I

0.15205

0.982

20_A

82_R

0.15193

0.981

55_V

68_I

0.15187

0.981

12_D

79_Q

0.15071

0.973

62_A

66_P

0.14727

0.951

78_L

83_N

0.14655

0.946

72_E

82_R

0.14595

0.942

24_L

28_L

0.14256

0.921

72_E

76_K

0.14176

0.915

31_G

54_G

0.14037

0.906

68_I

83_N

0.14036

0.906

54_G

61_G

0.14033

0.906

11_K

17_L

0.14015

0.905

37_A

40_I

0.13867

0.895

68_I

71_T

0.13782

0.890

48_V

52_V

0.13617

0.879

26_R

30_S

0.13571

0.876

40_I

44_Q

0.13565

0.876

42_G

54_G

0.13541

0.874

14_R

84_Q

0.135

0.872

48_V

81_I

0.13491

0.871

31_G

58_G

0.13453

0.869

56_G

64_V

0.13252

0.856

36_V

67_M

0.13087

0.845

16_G

83_N

0.13086

0.845

44_Q

55_V

0.13043

0.842

31_G

34_G

0.13002

0.840

47_G

58_G

0.12894

0.833

24_L

86_D

0.12865

0.831

50_G

53_K

0.12813

0.827

83_N

86_D

0.128

0.827

13_L

44_Q

0.12772

0.825

35_I

59_V

0.12751

0.823

71_T

78_L

0.12547

0.810

56_G

59_V

0.12478

0.806

29_Q

36_V

0.12454

0.804

36_V

41_E

0.12422

0.802

11_K

15_E

0.12388

0.800

43_A

50_G

0.12349

0.797

10_P

83_N

0.12336

0.797

39_P

53_K

0.12289

0.794

22_Q

30_S

0.12251

0.791

51_F

70_A

0.12217

0.789

78_L

84_Q

0.12201

0.788

75_S

78_L

0.12192

0.787

35_I

79_Q

0.1216

0.785

79_Q

84_Q

0.12132

0.783

28_L

57_K

0.12112

0.782

24_L

70_A

0.12017

0.776

37_A

68_I

0.12015

0.776

19_Q

23_S

0.11993

0.774

36_V

46_E

0.11977

0.773

54_G

58_G

0.11961

0.772

78_L

86_D

0.11947

0.771

23_S

68_I

0.11893

0.768

26_R

82_R

0.11767

0.760

9_Q

60_P

0.11704

0.756

42_G

46_E

0.11644

0.752

13_L

84_Q

0.11554

0.746

22_Q

28_L

0.11437

0.739

49_K

52_V

0.11416

0.737

29_Q

35_I

0.11403

0.736

25_G

66_P

0.11378

0.735

35_I

38_K

0.11329

0.732

72_E

75_S

0.11318

0.731

10_P

15_E

0.11282

0.729

60_P

73_A

0.11266

0.727

38_K

44_Q

0.1124

0.726

57_K

70_A

0.11123

0.718

40_I

50_G

0.11115

0.718

31_G

42_G

0.11054

0.714

13_L

30_S

0.11006

0.711

51_F

85_L

0.11002

0.710

52_V

59_V

0.10982

0.709

31_G

61_G

0.10894

0.703

28_L

70_A

0.10885

0.703

Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.