Endo- and Exo-Toxins: Anaphylaxis (Ascorbate Depletion)

Exo-toxins are produced and emitted by
bacteria in both acute and chronic infections.Microbes produce endo-toxinswhen they die.Body cells that die
also produce toxins. Toxins act to cause anti-oxidants to lose one or more
electrons and toxins become deactivated in part by this action. The
anti-oxidant AA converts to oxidant DHA and must be excreted or it will kill
body cells. Allergens and other immune cells, recognizing infections, cause
immune mast cells to produce products that kill microbes and body cells, that
oxidize cholesterol and lipids, and that produce more toxins.Oxidation of lipids make neurotoxins.Peroxides rapidly deplete free vitamin
C.Intake of enoughantioxidant AA stops this toxin/oxidation
cascade.

Vitamin C is ascorbic acid (AA). It is present and
stored in the body as ascorbate.It has
three forms: anti-oxidant, single-oxidized and double oxidized.The double oxidized form is dehydroxy
ascorbic acid. (DHA, or sometimes, DHAA)AA takes part in many life-critical chemical pathways, where it is
recycled.

AA is an essential molecule; we must eat it; we do
not make it. We can store a limited amount of it, but when that amount is
depleted by ever increasing toxins, we get very sick.Indeed, the sickness, pain, itching, irritation, inflammation
that we feel are the feelings of AA depletion.If we quickly replace enough AA, we immediately feel better, until the
toxins deplete that new AA, and we need to intake more.

When free AA is depleted, and the amount of toxins
is still large compared to the amount of systemic AA, most free AA converts to
DHA, and the life-giving chemical pathways dependent on AA are blocked. Vital
chemical reactions stop.The ratio of
AA/DHA nears unity or below, histamine is produced by immune mast cells and
blood levels of histamine rise exponentially. Histamine poisons the system, and
the blood vessels start to leak blood and other fluids.Extreme allergic respiratory tract distress
reactions occur, itching, pain and inflammation can and do result.

As
a last life saving measure, an emergency injection of adrenaline can cause
release of a few (~5 grams) of AA from the adrenal glands. When that is
converted to DHA the AA/DHA ratioagain
plummets.If no supplemental AA is
provided by injection, anaphylaxis and death can result.The adrenaline injection would not be needed
if AA was supplied IV in large enough (multi tens of grams per hour)
quantities. Along with a need for an adrenaline shot, goes the need for
repeated supplemental AA intake. See: How
Vitamin C Works

An
autoimmune cascade of toxins is the result of AA/DHA <1 and declining.

DHA is an oxidant and must be excreted, requiring
water intake, and free flow of urinary functions.

High intake of supplementary anti-oxidants is
needed. IV Glutathione intake can act to reduce the DHA, but this is not
usually provided.Frequently-repeated
supplemental multiple (2-3) gram quantities of AA intake are an economical way
to improve and maintain the high values of the AA to DHA ratio and improve the
chemical pathways operation.This
applies both during emergency crisis and to speed recovery.Additional antioxidants like CoQ10, vitamin
A and vitamin E should also be supplemented during recovery.

If the AA/DHA ratio is in the range 4-10 vitality is
good and toxemia risks are low.However, the blood half-lifetime of AA is ½ hour. So with systemic
toxemia, the AA/DHA ratio can change dynamically in just a few minutes or
hours.After 6 hours the AA level can
deplete to ½ to the 12th power, i.e. 1/4000th of the
starting value, to a negligible, not protective amount.Oral AA intake, gut-to-blood
transfer-efficiency is less than 15% for water soluble AA.

Forms of Ascorbic
Acid

Oral (water soluble) AA can be in the form of AA,
sodium ascorbate, calcium ascorbate (ester-C), magnesium ascorbate, and
ascorbyl palmitate.Health supplement
suppliers market these forms.

Another form of oral-intake AA, with superior
pharmacokinetics and effectiveness, is Liposomal
Vitamin C.Liposomal AA (L-AA)
is AA nano-encapsulated (homogenized) with phospholipid lecithin.Its transport from gut to blood is more than
5 times better than for water soluble AA. Also, L-AA crosses the blood brain
barrier better.

L-AA has an affinity (attraction) for microbes
(bacteria and viruses) and body cells with lipid envelopes. L-AA delivers AA
7-11 times more effectively than water-soluble forms of AA to the cells, where the
AA acts to kill microbes and microbe invaded cells.

IV AA and parenteral AA is usually sodium ascorbate,
sometimes with a small fraction of magnesium ascorbate and other critical
electrolytes.Magnesium helps reduce
the occurrences of heart fibrillations, because magnesium deficiency is
associated with higher fibrillation risk. Orthomolecular MDs are familiar with
IV AA administration.See Papers by
Drs. Klenner and Cathcart.

Multi
Toxemia Case History:

COPD Respiratory Polymicrobial Infections; Treatment is
symptomatic.Responds positively to AA
in levels over 8 grams per day 4-6x/d of 2 grams.

UTI Blockage, Infection & Toxemia: failure to void, always a
full bladder, incontinence; Constant/recurring UTI infections.Urologist failed to see patient because his
building lost electric power and facility was blacked out. Ultrasound room had
power and full bladder was confirmed. Patient has had great difficulty
obtaining urine sample of any quantity for period of many weeks.Cause of UTI blockage is unknown, blockage
location below bladder.Hysterectomy?
Structural degeneration of supporting cartilage resulting from Cipro?Stones?Effects of blockage on kidneys? Unknown, but worrisome. Never been
catheterized.Should she be?
Periodically?