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Doctor insights on:
Treat Lactic Acidosis

1

Lactic acidosis:
Severe lactic acidosis (la) is often associated with poor prognosis. Recognition and correction of the underlying process is the major step in the treatment of this serious condition. Intravenous administration of sodium bicarbonate (sb) has been the mainstay in the treatment of lactic acidosis. Dialysis, peritoneal in particular, can also be used in some cases to avoid a massive sb load.
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Lactic acidosis is the buildup of lactic acid in the blood, either from an increase in the body's production or the kidney being unable to remove lactic acid effectively. The most common causes are intense exercise (increased production of lactic acid) or kidney failure (unable to effectively remove lactic acid from blood). Other causes include blood infections (sepsis) and inability to breathe effectively (respiratory failure).
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3

Yes:
Many foods are acidic in nature and so anything acidic can make an acidosis worse. Alkaline diets (increasing avocado, kale, spinach, cucumber, celery for example) can help balance and acidic condition. Meats are very acidic, by the way.
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4

Dangerous condition:
The body generates energy by breaking down fat and sugar thru a very efficient mechanism that uses oxygen and produces carbon dioxide and water. When this mechanism fails, there is another inefficient back up system that generates lactic acid. Poor blood flow, low oxygen, medications, poisons, excessive exercise can cause this lactic acidosis. It should be corrected promptly.
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5

Lactic acidosis:
Most cases of type a lactic acidosis are due to marked tissue hypoperfusion in shock or during cardiopulmonary arrest. In type b lactic acidosis, systemic tissue hypoperfusion is not apparent. Metformin therapy for type ii diabetes can cause it, although the likelihood of this is relatively low. Risk factors for this include impaired kidney function and liver disease or concurrent alcohol abuse.
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9

Lactic acidosis:
Please go online to "www.ncbi.nlm.nih.gov/" and look up lactic acidosis and diabetes.
It won't be easy reading but worth a look.
You can also go to PubMed and search for lactic acidosis and diabetes.
Take your time learning about this.
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10

See below:
La arises from impairment of gluconeogenesis. Lactic acid is generated both in the liver and muscle and is oxidized to pyruvic acid and then converted via the gluconeogenenic pathway to g6p. Accumulation of g6p inhibits conversion of lactate to pyruvate. The Lactic Acid level rises during fasting as glucose falls. In people with gsd i, it may not fall entirely to normal even when gluc levels r nml.
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Normally our body chemistry is kept in a narrow range, and in particular the amount of acid in the body is kept within a narrow range. The amount of acid is measured by a value called the ph. It is normally a value between 7.35 and 7.45, values below 7.35 are considered to be "acidotic" a patient with this value of the blood chemistry would have an "acidosis".
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