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Abstract

Dr. Jaques is unusually qualified to be the author of this short monograph. He was a member of the original research team that investigated the use of heparin in anticoagulant therapy. During the 30 years since, he has continued investigation of the problems of thrombosis and anticoagulants.

His first chapter briefly defines the subject of anticoagulants and the relationship of modern pharmacology to these drugs. Next follows, logically, a discussion of thrombosis, with suggestions of mechanisms responsible for the effect of anticoagulant therapy. Heparin, a direct anticoagulant, and the indirect anticoagulants are discussed separately, with well-documented evidence for their actions.