Use the labels in the right column to find what you want. Or you can go thru them one by one, there are only 14807 posts. Searching is done in the search box in upper left corner. I blog on anything to do with stroke.DO NOT DO ANYTHING SUGGESTED HERE AS I AM NOT MEDICALLY TRAINED, YOUR DOCTOR IS, LISTEN TO THEM. BUT I BET THEY DON'T KNOW HOW TO GET YOU 100% RECOVERED. I DON'T EITHER, BUT HAVE PLENTY OF QUESTIONS FOR YOUR DOCTOR TO ANSWER.

Deans' stroke musings

Changing stroke rehab and research worldwide now.Time is Brain!Just think of all thetrillions and trillions of neuronsthatDIEeach daybecause there areNOeffective hyperacute therapies besides tPA(only 12% effective). I have 493 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It's quite disgusting that this information is not available from every stroke association and doctors group.My back ground story is here:http://oc1dean.blogspot.com/2010/11/my-background-story_8.html

Thursday, May 18, 2017

Current Stimulation May Keep Visual Neurons Alive After Injury – But at a Cost

Electrical stimulation of the brain by applying current to
the eye may help retinal nerve cells to survive injury. While these
neurons may not be restored to full function, they are prevented from
dying. But to achieve survival, their interconnections, the dendritic
tree, needs to disconnect rapidly for the protective action to unfold.
In a study published in Scientific Reports, researchers from Magdeburg
University (Germany) and The Chinese University of Hong Kong report that
for rats and mice, repetitive transorbital alternating current
stimulation (rtACS) may help preserve visual neurons from cell death
after injury.
Because the tissue at the back of the eye, the retina, is part of the
brain, researchers can directly observe how brain cells react in the
living animal. The researchers repeatedly monitored neurons in both rat
and mouse retinas after an optic nerve injury and measured neuronal
death after this lesion. Surprisingly, a neuroprotective treatment with
electrical alternating current stimulation increased cellular survival
in the eye´s retina, but it also induced a fast and complete
stripping-off of the neuron’s dendritic tree. The dendrites are like a
tree receiving many thousands of signals from other neurons. This
enables them to process visual information and then transmit the signals
along the optic nerve towards the brain. By retracting its dendrites,
the cell withdraws itself from this intercellular communication network
and becomes silent – which helps its survival.
The test animals were divided into groups and subjected to both real
and sham treatments. For the rats, optic nerve crush (ONC) was used to
induce an injury in some of the animals to mimic glaucoma. Some animals
and not others (sham) were treated with rtACS, resulting in three test
groups: ONC/rtACS, ONC/Sham, and Sham/Sham. Using in vivo confocal
neuroimaging (ICON) and measurements of Visual Evoked Potentials (VEP),
the researchers could determine whether a neuron had survived and
whether it was still functioning. The ONC and the first rtACS
stimulation were done on day zero. ICON was performed on day 4, followed
by rtACS or sham stimulation. On day 7 post ONC another ICON was
performed.
For the mice, a confocal laser ophthalmoscope was used to image the
dendritic structures of the retina for three groups of subjects,
ONC/rtACS, ONC/Sham and Sham/rtACS. The mice received rtACS on days 0,
3, 6, 9 and 12 after ONC and images were taken on days 3, 7 and 14.
According to lead author Petra Henrich-Noack, PhD, Institute of
Medical Psychology, Otto-von-Guericke University, Magdeburg, Germany,
“With our experiments, we have detected so far unknown ‘silent survivor
cells’ in the brain and it will be exciting to find out whether they
later die or can be reactivated.” Surprisingly, neurons in the retina of
animals that survived better when treated with rtACS lost their
dendritic tree completely within the first 3 days after the lesion. The
authors suggest that this early structural isolation might protect the
neurons from the “toxic” excitation that is known to appear soon after
brain damage.
Co-author Christopher Kai-Shun Leung, MD, of The Chinese University
of Hong Kong, adds, “Although we could see the surviving neuronal cells
when looking with an adapted microscope through the eye to the retina,
the lesion was apparently too severe to detect any improvement in visual
function, which was observed after a similar kind of stimulation in
glaucoma patients at the chronic stage”.
Co-investigator Bernhard A. Sabel, PhD, Director of the Institute of
Medical Psychology, Otto-von-Guericke University, Magdeburg, Germany,
notes that rtACS is being used successfully in a clinical setting for
the treatment of vision loss. The Magdeburg group has been looking into
the effects of non-invasive brain stimulation via the eye for many
years. Several studies with patients suffering from vision impairments
demonstrated that rtACS is a successful strategy for rehabilitation
months and years after the damage had appeared, leading to significantly
improved visual abilities. But he notes that more work needs to be done
to better understand the mechanisms of brain stimulation in patients
with vision loss.http://www.imp.ovgu.de/

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Canoeing Moose

Just because my goal is to get back to canoeing and this moose is so ripped and cool looking. And he's even a solo paddler. But his right hand on the T-grip is wrong and the right arm should be extended.