Glucose directly activates the satiety centers. Fructose does not activate them

A Straw Man argument as folk simply don't consume beverages that're either 100% glucose or 100% fructose in the normal course of events. Anyone who wishes to test the veracity of this statement for themselves should give it a try.

But looking at the prevalence of high-fructose corn syrup as a sweetener in so many foods today--as it's cheaper than glucose--and looking at the high caloric and empty nutritional values in so many of these foods, points to the problem.

HFCS isn't used as an alterntive to glucose (glucose, in fact, isn't very sweet) It's used in the US as an alternative to sucrose.....common table sugar. The problem isn't related so much to the HF-ness (the amount of fructose is pretty much comparable to the level in sucrose) as just eating too much sugar (along with too much everythijng else)

As it happens, one part of the World with the most rapidly increasing rate of obesity is the UK.....where sucrose.....common table sugar....is still the predominant sweetener in foostuffs.

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