The aim of the present study was to evaluate of the clinical and epidemiological characteristics of influenza in children of the Ryazan region in season 2015–2016.

Patients and Methods. It was studied of 24 cases of children who treated in Ryazan City Clinical Hospital №11.

Results. The flu epidemic in 2015–2016 years in the Ryazan Region began in January 2016, rise in the incidence, with a peak incidence at 4–6 weeks of the beginning of the epidemic. The highest incidence rate (1.4 times) was observed among children under 14 years (37.16 vs. 26.68/100 000), but in the age group of 15–17 years old children observed influenza decline from 18.66 in 2015 up to 7.22/100,000 in 2016. In children, who hospitalized with influenza, dominated by children of preschool age (87.5%), living in urban areas (66.7%), not attending organized children's groups (58.3%), haven't received vaccination against influenza. RNA of influenza A (H1N1) pdm09 has 87.5% patients.

Conclusions. Influenza A (H1N1)pdm09 was prevailed among the studied patients. High rate of immunization in children contributed to the low level of influenza. Early hospitalization contributed to a favorable outcome of the disease.