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Strong was born on February 12, 1973, in Toronto, Ontario, to Syd and Lucy Charendoff. Her family, Jews who lived in Russia, had immigrated to Canada after escaping the Anti-Jewish pogroms in the Russian Empire.[3] Her parents ran a candy and novelty store called The Wiz, and Syd had also worked as a pharmacist. She and her older sister Marla were raised in Toronto. At age four, she became interested in acting and volunteered to be a soloist at a school production.[4] She worked with the Yiddish Theater; though she did not know the Yiddish language, she memorized her lines phonetically. She also performed with the Toronto Jewish Theater (TJA), where she acted in A Night of Stars and was featured in an audiotape for "Lay Down Your Arms" with the Habonim Youth Choir, where she sang the lyrics in both English and Hebrew.[4]

In 2013, Strong won the Shorty Award for "Best #Actress" for her use of social media.[18] The Behind the Voice Actors website selected her for a BTVA Voice Acting Award for Voice Actress of the Year for 2013,[19] and nominated her for the 2011 and 2012 years.[20][21]

Strong was the roommate of actress Neve Campbell. They both auditioned for the role of Julia in the 1990s TV series Party of Five, and Campbell ultimately won the role.[22] Strong did appear in one episode playing Lorna.[23]

In 1999, she met Craig Strong, a former American actor-turned real estate agent;[24] they got married on May 14, 2000. They have two sons: Sammy (born 2002) and Aden (born 2004).[25] Their family resides in Los Angeles, where they run VoiceStarz, an Internet-based company that teaches people how to get into the voice-over business.[26] Strong and her husband developed and patented a line of baby bottles with caps that their user can set to note the calendar date for breast milk storage.[27][28]

She was involved with a charity group called Bronies for Good where she helped raise funds for a family whose daughter had a brain tumor.[7][29] In 2012, during the BronyCon event in New Jersey, she attended a lunch with fans from the military.[30]