DAC® barrier effect

The application of DAC® disrupts the ability of pathogens to bind to the implant surface, inhibiting the initial stages of bacterial colonisation that would then result in biofilm formation.
DAC® forms a hydrogel that acts as a temporary barrier, providing an effective mechanism for prevention of bacterial infection.

The DAC® Hydrogel defensive mechanism can be illustrated in three stages:

Immediately before surgery

The implant surface is evenly coated with the DAC® hydrogel.

Immediately after surgery

Bacterial adhesion and colonisation of the implant surface is interrupted by the DAC® hydrogel layer and by its hydrophilic properties.

Few days after surgery

Bacteria left on the implant surface or on the hydrogel are identified and attacked by the immune system.

The hydrogel it is completely absorbed within 72 hours from its application, and therefore it has no adverse effect on osseointegration or the bone healing process (1).

Experimental studies demonstrated that, as a complement to its barrier effect, the hydrogel powder could be hydrated with a solution of water for injectable preparations containing a final concentration between 2% and 5% of Vancomycin or Gentamycin. In vitro, in vivo, as well as clinical studies demonstrated how these antibiotics are compatible with DAC®, with no negative effect on the hydrogel. Optional antibiotic usage (they are not included in the DAC® procedure kit) did not result in any adverse effect in the clinical studies to date. The decision to add antibiotics is the decision and responsibility of the operating surgeon.