Conclusion: Many of the studies clearly revealed that most of the chalcones showed selective, reversible and potent
MAO-B inhibition compared to MAO-A. Recent studies also showed that heteroaryl-based chalcones are potent MAO-A
inhibitors.

Abstract:Introduction: Chalcones are one of the major classes of naturally occurring compounds and
have a vast significance in medicinal chemistry, presenting with a wide scope of pharmacological actions.

Conclusion: Many of the studies clearly revealed that most of the chalcones showed selective, reversible and potent
MAO-B inhibition compared to MAO-A. Recent studies also showed that heteroaryl-based chalcones are potent MAO-A
inhibitors.