Properties for Leptin Protein

Datasheet Extract

Purity

Protein

Application

Western Blot, Useful in Western Blot, Western Blot

Background

Leptin is a 16-kDa nonglycosylated hormone that is produced in mature adipocytes. Leptin acts primarily in the hypothalamus to reduce food intake and body weight. In ob/ob mice, the gene encoding leptin is mutated, resulting in morbid obesity and associated abnormalities, including hyperphagia, hypothermia, diabetes and infertility.Originally discovered in the mouse, the cDNA for leptin has been so far cloned from a variety of species including human, rat, cow, chicken, pig, sheep and dog.Recombinant mouse leptin was overexpressed as insoluble protein aggregate in E.coli and purified by FPLC gel-filtration chromatography, after refolding of the isolated inclusion bodies in a renaturation buffer.

Concentration

1 mg/ml

Storage

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Format

Buffer System:

No Preservative

Purity:

Protein

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