This stuidy shown that the mRNA expression of IL-33 and ST2 receptors is increased in the CNS of Rocio virus-infected WT mice and that ST2(-/-) mice showed increased susceptibility to infection.

Liver Treg cells show a high expression of ST2 (显示 SULT2A1 蛋白), a cellular receptor for tissue alarmin IL-33 (显示 IL33 蛋白), which is strongly upregulated in the liver of infected mice. These results illustrate the importance of IL-33 (显示 IL33 蛋白) in the suppressive function of liver Treg cells during Cytomegaloviruses (CMVs) infection.

Serum levels of IL33R were positively correlated with cognitive performance in patients with schizophrenia.

Interleukin 1 receptor-like 1 (ST2/IL1RL1) is a biomarker for cardiac stress and heart failure, which can be associated with cocaine use. Data suggest that serum ST2/IL1RL1 levels are up-regulated by cocaine use; cocaine use appears to be associated with subclinical cardiac stress and damage outside of acute cardiac events; elevated serum ST2/IL1RL1 levels may serve as biomarkers for cocaine-induced cardiac complications.

蛋白简介IL1RL1

蛋白简介

The protein encoded by this gene is a member of the interleukin 1 receptor family. Studies of the similar gene in mouse suggested that this receptor can be induced by proinflammatory stimuli, and may be involved in the function of helper T cells. This gene, interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2) and interleukin 1 receptor-like 2 (IL1RL2) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. Alternative splicing of this gene results in multiple transcript variants.