Denosumab (AMG 162) in Bisphosphonate Naive Metastatic Breast Cancer

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Number of Participants Achieving 65% or More Reduction in Urinary N-telopeptide (uNTx) From Baseline at Week 13 [ Time Frame: Baseline and Week 13 ]

The number of participants achieving a 65% reduction or more in uNTx from Baseline at Week 13. Calculation used is ((Week 13 value - Baseline value) / Baseline value ) x 100 and participants were considered having a 65% reduction or more if their value was ≤ -65%.

Number of Participants Achieving 65% or More Reduction in uNTX From Baseline at Week 25 [ Time Frame: Baseline and Week 25 ]

The number of participants achieving a 65% reduction or more in uNTX from Baseline at Week 25. Calculation used is ((Week 25 value - Baseline value) / Baseline value) x 100 and participants were considered having a 65% reduction or more if their value was ≤ -65%.

Time to 65% or More Reduction in Urinary N-telopeptide (uNTX) From Baseline [ Time Frame: Baseline to Week 57 ]

Kaplan-Meier estimate of the median time from enrollment to the first occurrence of a reduction of uNTx of ≥ 65% compared to Baseline. For participants whose uNTx did not fall below 65% of the Baseline value, the time was censored at time of last evaluation of uNTx.

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