Students Mentored

More than 150 post-doctoral fellows, graduate students and undergraduate students have received training in Dr. Fenselau’s laboratories at Johns Hopkins Med School, UMBC and the University of Maryland.

Research

Historically our research program has focused on the exploitation of mass spectrometry in biomedical research. Through the last fifteen years we have helped to open proteomics, the post-genomic science that provides unbiased and high throughput interrogation of large protein mixtures.

Analysis of branched proteins

We are applying middle-out and top-down strategies to decipher the number of subunits and points of attachment of ubiquitins in anchored and unanchored polyubiquitins isolated from exosomes (Cannon et al, Analytical Chemistry 2012).

Exosomes and their proteomes

We are characterizing the protein and RNA cargos carried by exosomes shed by myeloid derived suppressor cells in the tumor microenvironment (Burke et al, J. Proteome Research 2014). This continues our long-standing interest in mechanisms of tumor resistance to therapeutics.