Industry Insights

The global amniotic membrane market size was valued at USD 2.26 billion in 2017 and is estimated to register a CAGR of 12.6% during the forecast period. The amnion is the innermost layer of the placenta and is used for wound healing mainly due to its bacteriostatic and pain reduction properties. Rising awareness in the recent past has led to a surge in the number of transplants leading to increasing demand for these tissue-based products. It has also led to a rise in the number of donations thus, fueling market growth.

Typically, amniotic membranes are used for indications, such as pterygium excisions, reconstruction of the conjunctiva surface, corneal ulcers, surgical wounds, pressure and venous leg ulcers, regenerative medicine, and limbal stem cell deficiency. Thus, factors such as rising R&D investments in the field of stem cell and regenerative medicine and global rise in the number of surgeries being performed are fueling market growth.

Amniotic membranes are used in two categories, as a surgical graft or as a biological bandage for the treatment and management of wounds. The product usage facilitates re-epithelization acting as a scaffold when used as a graft. Its anti-inflammatory and anti-scarring properties are especially vital in case of burn injuries reducing intensified inflammation and discomfort.

The use of amniotic membranes is widely seen in the treatment of eye surface disorders. Treatment of bacterial keratitis, corneal ulcers, cataract, glaucoma, bullous keratopathy, corneal degeneration, ocular dystrophy, eyelid reconstruction, and various others. Increasing number of ophthalmology surgeries being performed due to rising geriatric population across the globe, is generating a huge demand for these tissue-based products.

Application Insights

Based on application, the market is segmented into surgical wounds, ophthalmology, and others. These products are most often used in ophthalmic surgeries to initiate faster recovery while reducing inflammation. These membranes are also used in reconstructive surgeries to reduce scarring and promote healing. According to estimates from American Society of Plastic Surgeons, over 17.5 million surgical cosmetic procedures were performed in U.S. in 2017. These facts are indicative of the rising number of individuals undergoing surgery to enhance their aesthetic appeal.

Thus, high product demand in cosmetic surgeries is boosting the market growth. These products are also used in reconstructive procedures, which is also propelling their demand. Usage of amniotic membranes for burn injury treatments enables rapid wound healing and epithelialization. It is also proven to reduce pain and facilitate easy movement of the affected area. Since the usage of this method proves to be cheaper than xenografts and allografts, it is increasingly being used across the globe, which is accelerating the segment growth.

End Use Insights

On the basis of end use, the market is segmented into hospitals, Ambulatory Surgical Centers (ASCs), specialty clinics, and research and academic institutes. Hospitals are the primary care settings facilitating easy treatment for a wide range of diseases. These end use settings held the largest market share owing to frequent visits by patients and its ability to cater to a varied range of surgical interventions.

Rising use of amniotic membranes in ASCs is driving the segment growth. The use of these products is easy and effective and also facilitates wound recovery without frequent visits to hospitals or clinics. Thus, the ASC settings are also likely to witness rapid growth over the next few years.

Specialty clinics that are taken into consideration in the study are burn centers, plastic surgery clinics, dermatology clinics, and others. As most of these require methods to prevent infections and promote effective wound healing, the use of amniotic membranes is frequently seen in these settings facilitating market growth.

Research and academic institutes segment also holds a significant share in the amniotic membrane market owing to increasing R&D investments by major market players and hospitals to understand the possible product applications. The amniotic membrane provides a substrate for stem cells and can be used in various applications, propelling increasing research on the subject.

Enzyme Insights

Based on enzyme, the market is segmented into cryopreserved and dehydrated amniotic membranes. Cryopreserved amniotic membrane held the largest market share owing to high effectivity and usage. The segment is anticipated to expand further at a lucrative CAGR over the forecast period. Cryopreserved membrane is typically stored in cell culture medium that contains 50% glycerol at a temperature of -80°C.

Amniotic membrane is preserved in cryopreserved amniotic membranes with its biological and histological properties. Thus, cryopreserved products are most often used in ocular surgeries facilitating faster recovery and reduced inflammation of the eye.

Dehydrated amniotic membranes, such as PalinGen, FlōGraft, AmbioDisk, and AmnioFix, are used for treating various surgical wounds, reconstruction procedures, and venous and pressure leg ulcers owing to properties, such as its ability to maintain a watertight seal, inhibit inflammatory responses, and prevent disease transmissions. Usually, these are used as a biological bandage to promote healing. All these factors are anticipated to fuel the segment development in the near future.

Regional Insights

North America led the market in 2017. The presence of well-developed healthcare infrastructure and leading companies have fueled market growth in the region. Moreover, adoption of advanced technologies and increased focus on alternative technologies in this region is expected to drive the segment further.

The European region accounted for the second-highest revenue and is expected to witness a CAGR of 11.9% over the forecast years. The healthcare system in the European region is publicly funded and some countries have adopted universal health care systems. Presence of target population is the key factor propelling the region’s development.

According to the World Health Organization (WHO), non-communicable diseases, such as Cardiovascular Diseases (CVDs), chronic respiratory diseases, diabetes, and cancer together account for over 86% of deaths and 77% of the disease burden in the European region. Thus, with growing prevalence of chronic diseases, rise in surgical interventions is anticipated, accelerating market growth.

Asia Pacific region is projected to expand at the highest CAGR in the forecast period. Most of the countries in this region are economically developing and the disposable income is gradually increasing. Many multinational companies are heavily investing in this region. These factors are supporting region’s growth. Presence of technologically advanced countries in terms of healthcare and medical research, is likely to help boost market growth in APAC.

Majority of these companies have a well-established portfolio and have strong collaborations with tissue banks and hospitals to ensure placental donations. Almost all of the key market players are accredited by the American Association for Tissue Banks (AATB) to provide quality and sterile products. These factors thus are anticipated to aid in the growth of the market during the forecast period.

Companies are also involved in developing and marketing of membranes that are solely focused on specific areas of application. For instance, AmnioFix developed by MiMedx Group Inc. is a dehydrated product that is used particularly for surgical incisions, as it acts as a barrier membrane and reduces scar tissue formations.

In addition, M&A and strategic agreements are some of the initiatives being undertaken by key companies, which are expected to propel the market. A lot of companies are also engaged in product licensing and distribution.

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Segments Covered in the Report

This report forecasts revenue and volume growth at global, regional, and country levels and provides an analysis of the latest industry trends in each of the sub-segments from 2014 to 2025. For the purpose of this study, Grand View Research has segmented the global amniotic membrane market report on the basis of enzyme, application, end use, and region: