NAPD Most Wanted List - Level 1: Each copy of this card costs 1 universal influence, which is separate & in addition to the normal printed influence, and counts against all Identities influence limits, even those in the same faction. [MWL v1.2]

Thoughts

if you value 1 click = 1 card = 1 credit then after 5 turns you "break even", but as card draw is probably worth more than a credit, Wyldside is actually "worth it" sooner

losing a click can be a pain against bioroids

with drawing that much, you have to think about how to get your cards out of your hand unless you wanna discard plenty
-- Public Sympathy comes to mind (or other hand size increase)
-- click-efficient economy is very welcome, like Modded or Liberated Accounts
-- arguably the "best" synergy is Personal Workshop: Just install stuff on the workshop and let them enter play at an opportune moment

being unique is no real drawback, as I couldn't envision having 2 in play at the same time anyway

Party hard and pull everything out of your deck in half the time. It is very useful with the hand space through Public Sympathy, but it also works when you simply need to up your aggression. However, it is a mandatory effect that you can only remove with Aesop's Pawnshop, so keep at least one handy in any deck that runs this. Nothing is more sad than having 3 clicks as a runner with zero cards in your deck.

When using with Order and Chaos cards, think hard before using Day Job in any deck with this. The two cannot be used together, so use other event economy such as Liberated Account or Lucky Find.

Edit 4/29/15: Now you can combine this with Adjusted Chronotype to keep all of your clicks and still have the card draw. From Breaker Bay onward, this combo is amazing for any Anarch deck that needs more draw power. The influence cost of the combo is steep for other factions, however.