I'm like reynolds, only I have never used any other brand of primer than CCI. They are just so damn reliable, and I shoot ammo that I handloaded thirty years ago and it always goes boom. As far as the 25-06 goes PawPaw states that he has tested thoroughly the RL22 with heavy quarterbore. I have only tested 85 grain bullets with our 25-06, so I hope he replies to this thread for added information. (he says he loads for something like 5 or so different rifles in 25-06 so he'd know).