Zofran Injection

OVERDOSE

There is no specific antidote for ondansetron overdose.
Patients should be managed with appropriate supportive therapy. Individual
intravenous doses as large as 150 mg and total daily intravenous doses as large
as 252 mg have been inadvertently administered without significant adverse
events. These doses are more than 10 times the recommended daily dose.

In addition to the adverse reactions listed above, the
following events have been described in the setting of ondansetron overdose:
“Sudden blindness” (amaurosis) of 2 to 3 minutes' duration plus severe
constipation occurred in one patient that was administered 72 mg of ondansetron
intravenously as a single dose. Hypotension (and faintness) occurred in another
patient that took 48 mg of ondansetron hydrochloride tablets. Following
infusion of 32 mg over only a 4-minute period, a vasovagal episode with
transient second-degree heart block was observed. In all instances, the events
resolved completely.

CONTRAINDICATIONS

ZOFRAN Injection is contraindicated for patients known to
have hypersensitivity (e.g., anaphylaxis) to this product or any of its
components. Anaphylactic reactions have been reported in patients taking
ondansetron. [See ADVERSE REACTIONS].

The concomitant use of apomorphine with ondansetron is
contraindicated based on reports of profound hypotension and loss of
consciousness when apomorphine was administered with ondansetron.

Last reviewed on RxList: 12/23/2013
This monograph has been modified to include the generic and brand name in many instances.