Drug Class and Mechanism

Sibutramine is used for weight loss by changing composition of neurotransmitters in the brain. The process by which neurotransmitters attach themselves to other nerves and are taken up by the same nerves is called reuptake. Sibutramine stops this process of neurotransmitters like dopamine and serotonin. This causes the balance of neurotransmitters to alter thereby affecting the functioning of nerves. Patients taking this drug have shown 5-10% reduction in their base weight. It also helps to improve blood lipids.

Prescription, Storage and Dosage

The brand name under which this drug is found is Meridia. It is a prescription drug with no generic available. It is presented in the capsule form. These capsules should be stored at a temperature of 15-30o C. An airtight container, which is light and moisture resistant, is suitable for storing these capsules. It is prescribed for weight loss and is more effective when combined with a proper diet. It is recommended for patients with a body mass index of more than 30 kg/m2 and those that are susceptible to high cholesterol and diabetes mellitus. The dosage is once daily generally in the morning time. Dosage can be started with 10mg per day and gradually increased to 15mg to achieve the desired effect. It can be taken with or without consuming food.

Drug Interactions

Sibutramine is converted to its active form in the liver. However, drugs like Erythromycin, Cimetidine and Ketoconazole cause discrepancies in the conversion and effectiveness of Sibutramine. Certain other drugs, which result in similar reactions, include danazol, fluoxetine, verapami and itraconazole. This drug should not be taken along with MAO inhibitors and a minimum of 2 weeks interval should be given before starting sibutramine. It is advisable to avoid drinking excess alcohol while on sibutramine.

Sibutramine Side Effects

The less common side effects of sibutramine include irregular heartbeat, chills, high blood pressure, depression, swelling of limbs and painful menstruation. At times red rashes and spots are also seen on the skin. Convulsions, mood swings and weight gain are other unusual side effects. Taking sibutramine along with monoamine oxidase can cause severe seizures and life threatening effects called the serotonin syndrome. Sibutramine can also cause drowsiness and poor judgment. Therefore it is advisable to avoid taking the dose before an activity that requires an alert state of mind like driving. It is also known to cause dryness in the mouth and chewing sugarless candy or melting ice pieces in the mouth can help. It is important to check with the doctor if side effects increase or persist for a long period of time.

Note: Meridia (sibutramine) was withdrawn from the market due to the risk of cardiovascular threat on October 8,2010.