BioPAX pathway converted from "Phase II - Conjugation of compounds" in the Reactome database.Phase II - Conjugation of compoundsThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>GlucuronidationThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Formation of the active cofactor, UDP-glucuronateThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>LEFT-TO-RIGHT2.7.7.9UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucoseThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>G1PD-Glucose 1-phosphateD-glucopyranose 1-phosphatealpha-D-Glucose 1-phosphateCori esterD-Glucose alpha-1-phosphateReactome DB_ID: 29548cytosolGENE ONTOLOGYGO:0005829D-glucopyranose 1-phosphate [ChEBI:16077]D-glucopyranose 1-phosphateChEBICHEBI:16077Reactome Database ID Release 7229548Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29548ReactomeR-ALL-295483Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29548.3Reactomehttp://www.reactome.orgUTPuridine 5'-triphosphateUridine triphosphateReactome DB_ID: 29494UTP [ChEBI:15713]UTPuridine 5'-triphosphateUridine triphosphateChEBICHEBI:15713Reactome Database ID Release 7229494Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29494ReactomeR-ALL-294942Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29494.2PPipyrophosphatediphosphoric acidpyrophosphoric aciddiphosphateReactome DB_ID: 111294diphosphoric acid [ChEBI:29888]diphosphoric acidChEBICHEBI:29888Reactome Database ID Release 72111294Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=111294ReactomeR-ALL-1112943Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-111294.3UDP-GlcUDP-glucoseUDP-D-glucoseUDPglucoseReactome DB_ID: 29410UDP-D-glucose [ChEBI:18066]UDP-D-glucoseChEBICHEBI:18066Reactome Database ID Release 7229410Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29410ReactomeR-ALL-294103Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29410.3ACTIVATION8xUGP2Reactome DB_ID: 9901992UGP2UGP2E2R5R9Reactome DB_ID: 9901990UniProt:E2R5R9UGP2Canis familiarisNCBI Taxonomy9615UniProtE2R5R91EQUAL508EQUALReactome Database ID Release 729901990Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9901990ReactomeR-CFA-4531281Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-453128.18Reactome Database ID Release 729901992Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9901992ReactomeR-CFA-702811Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-70281.1GENE ONTOLOGYGO:0003983gene ontology term for cellular functionMIMI:0355Same Catalyst ActivityReactome Database ID Release 729901993Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9901993Reactome Database ID Release 729901995Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9901995ReactomeR-CFA-702861Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-70286.1Cytosolic UDP-glucose pyrophosphorylase 2 (UGP2) catalyzes the reaction of UTP and glucose 1-phosphate to form UDP glucose and pyrophosphate (Knop and Hansen 1970; Duggleby et al. 1996). UGP2 is inferred to occur in the cell as a homooctamer from studies of its bovine homologue (Levine et al. 1969).5427280Pubmed1970Uridine diphosphate glucose pyrophosphorylase. IV. Crystallization and properties of the enzyme from human liverKnop, JKHansen, RGJ Biol Chem 245:2499-5045348606Pubmed1969Uridine diphosphate glucose pyrophosphorylase. IILevine, SGillett, TAHageman, EHansen, RGJ Biol Chem 244:5729-348631325Pubmed1996Sequence differences between human muscle and liver cDNAs for UDPglucose pyrophosphorylase and kinetic properties of the recombinant enzymes expressed in Escherichia coli.Duggleby, RGChao, YCHuang, JGPeng, HLChang, HYEur J Biochem 235:173-9inferred from electronic annotationEVIDENCE CODEECO:0000203LEFT-TO-RIGHT1.1.1.22UDP-glucose is oxidised to UDP-glucuronateThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>H2OwaterReactome DB_ID: 29356water [ChEBI:15377]waterChEBICHEBI:15377Reactome Database ID Release 7229356Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29356ReactomeR-ALL-293564Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29356.4NADNAD+NAD(+)Nicotinamide adenine dinucleotideDPNDiphosphopyridine nucleotideReactome DB_ID: 29360NAD(1-) [ChEBI:57540]NAD(1-)adenosine 5'-{3-[1-(3-carbamoylpyridinio)-1,4-anhydro-D-ribitol-5-yl] diphosphate}NAD(+)NAD anionChEBICHEBI:57540Reactome Database ID Release 7229360Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29360ReactomeR-ALL-293605Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29360.52UDP-GlcAUDP-glucuronic acidUDP-alpha-D-glucuronic acidReactome DB_ID: 158601UDP-alpha-D-glucuronic acid [ChEBI:17200]UDP-alpha-D-glucuronic acidChEBICHEBI:17200Reactome Database ID Release 72158601Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=158601ReactomeR-ALL-1586013Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-158601.3H+protonhydronReactome DB_ID: 70106hydron [ChEBI:15378]hydronChEBICHEBI:15378Reactome Database ID Release 7270106Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=70106ReactomeR-ALL-701064Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-70106.42NADHReactome DB_ID: 73473NADH(2-) [ChEBI:57945]NADH(2-)NADH dianionadenosine 5'-{3-[1-(3-carbamoyl-1,4-dihydropyridin-1-yl)-1,4-anhydro-D-ribitol-5-yl] diphosphate}NADHChEBICHEBI:57945Reactome Database ID Release 7273473Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=73473ReactomeR-ALL-734734Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-73473.42ACTIVATION6xUGDHReactome DB_ID: 9913534UGDHUGDHE2R311Reactome DB_ID: 9913532UniProt:E2R311UGDHUniProtE2R3111EQUAL494EQUALReactome Database ID Release 729913532Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9913532ReactomeR-CFA-1735981Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-173598.16Reactome Database ID Release 729913534Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9913534ReactomeR-CFA-1736001Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-173600.1GENE ONTOLOGYGO:0003979Reactome Database ID Release 729913535Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9913535Reactome Database ID Release 729913537Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9913537ReactomeR-CFA-1735971Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-173597.1UDP-glucose dehydrogenase (UGDH) catalyzes the conversion of UDP-glucose to UDP-glucuronic acid. The cytosolic enzyme is active as a hexamer and performs two successive oxidations to convert the 6'-hydroxyl of UDP-glucose to a carboxylate with concurrent reduction of 2 mol of NAD+ to NADH.15044486Pubmed2004Characterization of human UDP-glucose dehydrogenase. CYS-276 is required for the second of two successive oxidationsSommer, BJBarycki, JJSimpson, MAJ Biol Chem 279:23590-6LEFT-TO-RIGHTSLC35D1 hexamer transports UDP-GlcA, UDP-GlcNAc from cytosol to endoplasmic reticulum lumenThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>UDP-GlcNAcUDP-N-acetyl-D-glucosamineUDP-N-acetyl-alpha-D-glucosamineUDP-N-acetylglucosamineReactome DB_ID: 162756UDP-N-acetyl-alpha-D-glucosamine [ChEBI:16264]UDP-N-acetyl-alpha-D-glucosamineChEBICHEBI:16264Reactome Database ID Release 72162756Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=162756ReactomeR-ALL-1627563Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-162756.3UDP-GlcNAcUDP-N-acetyl-D-glucosamineUDP-N-acetyl-alpha-D-glucosamineUDP-N-acetylglucosamineReactome DB_ID: 3499326endoplasmic reticulum lumenGENE ONTOLOGYGO:0005788Reactome Database ID Release 723499326Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3499326ReactomeR-ALL-34993263Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-3499326.3UDP-GlcAUDP-glucuronic acidUDP-alpha-D-glucuronic acidReactome DB_ID: 174384Reactome Database ID Release 72174384Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=174384ReactomeR-ALL-1743843Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-174384.3ACTIVATIONSLC35D1 hexamerReactome DB_ID: 9913993endoplasmic reticulum membraneGENE ONTOLOGYGO:0005789J9NSF8SLC35D1SLC35D1Reactome DB_ID: 9913991UniProt:J9NSF8SLC35D1UniProtJ9NSF81EQUAL355EQUALReactome Database ID Release 729913991Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9913991ReactomeR-CFA-1743611Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-174361.16Reactome Database ID Release 729913993Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9913993ReactomeR-CFA-1743881Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-174388.1GENE ONTOLOGYGO:0005461Reactome Database ID Release 729913994Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9913994Reactome Database ID Release 729913996Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9913996ReactomeR-CFA-1743681Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-174368.1The UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter (SLC35D1) in hexameric form transports both UDP-glucuronic acid (UDP-GlcA) and UDP-N-acetylgalactosamine (UDP-GalNAc) from the cytosol into the ER lumen across the ER membrane (Muraoka et al. 2001). These substrates participate in glucuronidation and/or chondroitin sulfate biosynthesis.11322953Pubmed2001Molecular characterization of human UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter, a novel nucleotide sugar transporter with dual substrate specificityMuraoka, MKawakita, MIshida, NFEBS Lett 495:87-93Reactome Database ID Release 729996683Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9996683ReactomeR-CFA-1735991Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-173599.1GENE ONTOLOGYGO:0006065gene ontology term for cellular processMIMI:0359Glucose 1-phosphate and UTP are the precursors to UDP-glucuronate formation. After oxidation of the resultant complex, UDP-glucuronate is transported to the ER lumen.17482904Pubmed2007Molecular mechanism of phase I and phase II drug-metabolizing enzymes: implications for detoxificationIyanagi, TInt Rev Cytol 260:35-112LEFT-TO-RIGHT2.4.1.17UGTs transfer GlcA from UDP-GlcA to O-centre substratesThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Converted from EntitySet in ReactomeO-centre functional group substrateReactome DB_ID: 174911paracetamolAcetaminophen (TN TYLENOL)Reactome DB_ID: 39427paracetamol [ChEBI:46195]paracetamolChEBICHEBI:46195Reactome Database ID Release 7239427Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=39427ReactomeR-ALL-394273Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-39427.3DSQDebrisoquinedebrisoquinReactome DB_ID: 211993debrisoquin [ChEBI:34665]debrisoquinIsocaramidineDebrisochinumChEBICHEBI:34665Reactome Database ID Release 72211993Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=211993ReactomeR-ALL-2119933Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-211993.3NHABPN-hydroxy-4-aminobiphenylReactome DB_ID: 34889N-hydroxy-4-aminobiphenyl [ChEBI:16580]N-hydroxy-4-aminobiphenylChEBICHEBI:16580Reactome Database ID Release 7234889Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=34889ReactomeR-ALL-348893Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-34889.3PhOHBenzenolphenolHydroxybenzenePhenic acidPhenylic acidReactome DB_ID: 29630phenol [ChEBI:15882]phenolChEBICHEBI:15882Reactome Database ID Release 7229630Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29630ReactomeR-ALL-296303Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29630.3Reactome Database ID Release 72174911Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=174911ReactomeR-ALL-1749111Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-174911.1UDPuridine 5'-diphosphateReactome DB_ID: 158602UDP [ChEBI:17659]UDPChEBICHEBI:17659Reactome Database ID Release 72158602Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=158602ReactomeR-ALL-1586022Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-158602.2Converted from EntitySet in ReactomeO-glucuronideReactome DB_ID: 174914ACAP-OGLUAcetaminophen O-glucuronideacetaminophen O-beta-D-glucosiduronic acidReactome DB_ID: 158604acetaminophen O-beta-D-glucosiduronic acid [ChEBI:32636]acetaminophen O-beta-D-glucosiduronic acidChEBICHEBI:32636Reactome Database ID Release 72158604Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=158604ReactomeR-ALL-1586043Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-158604.3DSQ-OGDebrisoquine O-glucuronideN-hydroxydebrisoquine O-glucuronideReactome DB_ID: 351779N-hydroxydebrisoquine O-glucuronide [ChEBI:65137]N-hydroxydebrisoquine O-glucuronideChEBICHEBI:65137Reactome Database ID Release 72351779Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=351779ReactomeR-ALL-3517793Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-351779.3N-hydroxy-4-aminobiphenyl O-glucuronideReactome DB_ID: 158727N-hydroxy-4-aminobiphenyl O-glucuronide [ChEBI:32649]N-hydroxy-4-aminobiphenyl O-glucuronideSource N-hydroxy-4-aminobiphenyl glucuronideChEBICHEBI:32649Reactome Database ID Release 72158727Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=158727ReactomeR-ALL-1587272Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-158727.2Phenyl glucuronatephenol O-(beta-D-glucuronide)Reactome DB_ID: 158857phenol O-(beta-D-glucuronide) [ChEBI:64681]phenol O-(beta-D-glucuronide)ChEBICHEBI:64681Reactome Database ID Release 72158857Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=158857ReactomeR-ALL-1588573Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-158857.3Reactome Database ID Release 72174914Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=174914ReactomeR-ALL-1749141Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-174914.1ACTIVATIONConverted from EntitySet in ReactomeUGTs (O-GlcA forming)UDP-glucuronosyltransferase (O-glucuronide forming isozymes)Reactome DB_ID: 9914317UGT1A6UGT1A6E2R043Reactome DB_ID: 9914231UniProt:E2R043UGT1A6UniProtE2R04327EQUAL532EQUALReactome Database ID Release 729914231Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914231ReactomeR-CFA-1585971Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-158597.1UGT2A1LOC475163F1Q1X4Reactome DB_ID: 9914235UniProt:F1Q1X4LOC475163UniProtF1Q1X421EQUAL527EQUALReactome Database ID Release 729914235Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914235ReactomeR-CFA-1749301Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-174930.1Converted from EntitySet in ReactomeHomologues of UGT2B10Reactome DB_ID: 9914257H9GWP5LOC609777UGT2B10Reactome DB_ID: 9914239UniProt:H9GWP5LOC609777UniProtH9GWP524EQUAL528EQUALReactome Database ID Release 729914239Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914239ReactomeR-CFA-1749191Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-174919.1J9JHZ5LOC100856068UGT2B10Reactome DB_ID: 9914243UniProt:J9JHZ5LOC100856068UniProtJ9JHZ524EQUAL528EQUALReactome Database ID Release 729914243Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914243ReactomeR-CFA-174919-21Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-174919-2.1L7N0M2LOC100686607UGT2B10Reactome DB_ID: 9914247UniProt:L7N0M2LOC100686607UniProtL7N0M224EQUAL528EQUALReactome Database ID Release 729914247Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914247ReactomeR-CFA-174919-31Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-174919-3.1L7N0M3LOC480777UGT2B10Reactome DB_ID: 9914251UniProt:L7N0M3LOC480777UniProtL7N0M324EQUAL528EQUALReactome Database ID Release 729914251Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914251ReactomeR-CFA-174919-41Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-174919-4.1Q6K1J1UGT2B31UGT2B10Reactome DB_ID: 9914255UniProt:Q6K1J1UGT2B31UniProtQ6K1J124EQUAL528EQUALReactome Database ID Release 729914255Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914255ReactomeR-CFA-174919-51Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-174919-5.1Reactome Database ID Release 729914257Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914257ReactomeR-CFA-174919-61Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-174919-6.1Converted from EntitySet in ReactomeHomologues of UGT2B11Reactome DB_ID: 9914269H9GWP5LOC609777UGT2B11Reactome DB_ID: 991425922EQUAL529EQUALReactome Database ID Release 729914259Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914259ReactomeR-CFA-1749231Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-174923.1J9JHZ5LOC100856068UGT2B11Reactome DB_ID: 991426122EQUAL529EQUALReactome Database ID Release 729914261Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914261ReactomeR-CFA-174923-21Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-174923-2.1L7N0M2LOC100686607UGT2B11Reactome DB_ID: 991426322EQUAL529EQUALReactome Database ID Release 729914263Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914263ReactomeR-CFA-174923-31Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-174923-3.1L7N0M3LOC480777UGT2B11Reactome DB_ID: 991426522EQUAL529EQUALReactome Database ID Release 729914265Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914265ReactomeR-CFA-174923-41Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-174923-4.1Q6K1J1UGT2B31UGT2B11Reactome DB_ID: 991426722EQUAL529EQUALReactome Database ID Release 729914267Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914267ReactomeR-CFA-174923-51Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-174923-5.1Reactome Database ID Release 729914269Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914269ReactomeR-CFA-174923-61Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-174923-6.1Converted from EntitySet in ReactomeHomologues of UGT2B15Reactome DB_ID: 9914281H9GWP5LOC609777UGT2B15Reactome DB_ID: 991427124EQUAL530EQUALReactome Database ID Release 729914271Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914271ReactomeR-CFA-1749351Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-174935.1J9JHZ5LOC100856068UGT2B15Reactome DB_ID: 991427324EQUAL530EQUALReactome Database ID Release 729914273Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914273ReactomeR-CFA-174935-21Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-174935-2.1L7N0M2LOC100686607UGT2B15Reactome DB_ID: 991427524EQUAL530EQUALReactome Database ID Release 729914275Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914275ReactomeR-CFA-174935-31Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-174935-3.1L7N0M3LOC480777UGT2B15Reactome DB_ID: 991427724EQUAL530EQUALReactome Database ID Release 729914277Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914277ReactomeR-CFA-174935-41Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-174935-4.1Q6K1J1UGT2B31UGT2B15Reactome DB_ID: 991427924EQUAL530EQUALReactome Database ID Release 729914279Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914279ReactomeR-CFA-174935-51Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-174935-5.1Reactome Database ID Release 729914281Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914281ReactomeR-CFA-174935-61Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-174935-6.1Converted from EntitySet in ReactomeHomologues of UGT2B28Reactome DB_ID: 9914293H9GWP5LOC609777UGT2B28Reactome DB_ID: 991428325EQUAL529EQUALReactome Database ID Release 729914283Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914283ReactomeR-CFA-29908631Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2990863.1J9JHZ5LOC100856068UGT2B28Reactome DB_ID: 991428525EQUAL529EQUALReactome Database ID Release 729914285Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914285ReactomeR-CFA-2990863-21Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2990863-2.1L7N0M2LOC100686607UGT2B28Reactome DB_ID: 991428725EQUAL529EQUALReactome Database ID Release 729914287Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914287ReactomeR-CFA-2990863-31Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2990863-3.1L7N0M3LOC480777UGT2B28Reactome DB_ID: 991428925EQUAL529EQUALReactome Database ID Release 729914289Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914289ReactomeR-CFA-2990863-41Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2990863-4.1Q6K1J1UGT2B31UGT2B28Reactome DB_ID: 991429125EQUAL529EQUALReactome Database ID Release 729914291Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914291ReactomeR-CFA-2990863-51Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2990863-5.1Reactome Database ID Release 729914293Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914293ReactomeR-CFA-2990863-61Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2990863-6.1Converted from EntitySet in ReactomeHomologues of UGT2B7Reactome DB_ID: 9914299UGT2B7LOC100686607L7N0M2Reactome DB_ID: 991429524EQUAL529EQUALReactome Database ID Release 729914295Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914295ReactomeR-CFA-1749241Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-174924.1UGT2B7UGT2B31Q6K1J1Reactome DB_ID: 991429724EQUAL529EQUALReactome Database ID Release 729914297Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914297ReactomeR-CFA-174924-21Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-174924-2.1Reactome Database ID Release 729914299Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914299ReactomeR-CFA-174924-31Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-174924-3.1Converted from EntitySet in ReactomeHomologues of UGT2A3Reactome DB_ID: 9914311UGT2A3E2QYB8Reactome DB_ID: 9914303UniProt:E2QYB8UniProtE2QYB824EQUAL527EQUALReactome Database ID Release 729914303Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914303ReactomeR-CFA-89417491Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-8941749.1UGT2A3LOC608760E2R375Reactome DB_ID: 9914307UniProt:E2R375LOC608760UniProtE2R37524EQUAL527EQUALReactome Database ID Release 729914307Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914307ReactomeR-CFA-8941749-21Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-8941749-2.1UGT2A3LOC475163F1Q1X4Reactome DB_ID: 991430924EQUAL527EQUALReactome Database ID Release 729914309Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914309ReactomeR-CFA-8941749-31Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-8941749-3.1Reactome Database ID Release 729914311Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914311ReactomeR-CFA-8941749-41Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-8941749-4.1UGT3A2UGT3A1F1PS55Reactome DB_ID: 9914315UniProt:F1PS55UGT3A2UniProtF1PS5523EQUAL523EQUALReactome Database ID Release 729914315Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914315ReactomeR-CFA-89417521Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-8941752.1Reactome Database ID Release 729914317Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914317ReactomeR-CFA-1749201Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-174920.1GENE ONTOLOGYGO:0015020Reactome Database ID Release 729914318Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914318Reactome Database ID Release 729914320Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914320ReactomeR-CFA-1749311Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-174931.1Typical O-centred substrates were chosen as examples for these isozymes. Many UDP-glucuronosyltransferases (UGTs) can transfer the glucuronyl moiety (GlcA) from UDP-GlcA to the O-centre functional group of many substrates to form 4-O-glucuronides (Casarett & Doull 1995, Babu et al. 1996).8687483Pubmed1996Glucuronide conjugates of 4-aminobiphenyl and its N-hydroxy metabolites. pH stability and synthesis by human and dog liver.Babu, SRLakshmi, VMHuang, GPZenser, TVDavis, BBBiochem Pharmacol 51:1679-859780071470513ISBN1995Casarett and Doull's Toxicology 5th EdnParkinson, ACasarett and Doull's Toxicology 5th Edn (Book): 113-186LEFT-TO-RIGHT3.2.1ABHD10 hydrolyses MPAGThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>AMPAGmycophenolic acid O-acyl-glucuronideReactome DB_ID: 5694574mitochondrial matrixGENE ONTOLOGYGO:0005759mycophenolic acid O-acyl-glucuronide [ChEBI:64689]mycophenolic acid O-acyl-glucuronidemycophenolic acid-O-acyl-beta-D-glucopyranuronosidemycophenolic acid acyl glucuronideAcMPAGmycophenolic acid acyl-glucuronideChEBICHEBI:64689Reactome Database ID Release 725694574Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5694574ReactomeR-ALL-56945743Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-5694574.3H2OwaterReactome DB_ID: 113521Reactome Database ID Release 72113521Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113521ReactomeR-ALL-1135213Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-113521.3MPAmycophenolic acidReactome DB_ID: 5694565mycophenolic acid [ChEBI:168396]mycophenolic acidMycophenolate(E)-6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoic acidMycophenolsaeureMicofenolico acidoChEBICHEBI:168396Reactome Database ID Release 725694565Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5694565ReactomeR-ALL-56945653Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-5694565.3GlcAD-glucuronic acidD-glucuronateReactome DB_ID: 5694569D-glucuronate [ChEBI:15748]D-glucuronateGlucuronateChEBICHEBI:15748Reactome Database ID Release 725694569Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5694569ReactomeR-ALL-56945693Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-5694569.3ACTIVATIONABHD10ABHD10J9P8H1Reactome DB_ID: 9975785UniProt:J9P8H1ABHD10UniProtJ9P8H153EQUAL306EQUALReactome Database ID Release 729975785Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9975785ReactomeR-CFA-56945771Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-5694577.1GENE ONTOLOGYGO:0004553Reactome Database ID Release 729975786Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9975786Reactome Database ID Release 729975788Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9975788ReactomeR-CFA-56945631Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-5694563.1Mycophenolic acid (MPA) is the active metabolite of the immunosuppressant drug mycophenolate mofetil (MMF) and is primarily metabolised by glucuronidation to a phenolic glucuronide (MPAG) and an acyl glucuronide (AMPAG), a potential immunotoxic metabolite. Mitochondrial mycophenolic acid acyl-glucuronide esterase (ABHD10) deglucuronidates AMPAG thereby ABHD10 could play a role in the protection against acyl glucuronide-induced toxicity (Iwamura et al. 2012).22294686Pubmed2012Human α/β hydrolase domain containing 10 (ABHD10) is responsible enzyme for deglucuronidation of mycophenolic acid acyl-glucuronide in liverIwamura, AtsushiFukami, TatsukiHiguchi, RyotaNakajima, MikiYokoi, TsuyoshiJ. Biol. Chem. 287:9240-9Reactome Database ID Release 729996685Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9996685ReactomeR-CFA-1565881Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-156588.1GENE ONTOLOGYGO:0052695Glucuronidation conjugation utilizes UDP-glucuronosyltransferases (UGTs; EC 2.4.1.17) to catalyze a wide range of diverse endogenous and xenobiotic compounds. Glucuronidation is the major pathway in phase II metabolism and accounts for approximately 35% of drug conjugation. UGTs are microsomal membrane-bound and catalyze the transfer of a glucuronate group of uridine diphosphoglucuronate (UDPGA, a co-substrate) to the functional group of specific substrates. UDPGA is synthesized from glucose-1-phosphate (G1P). G1P is required for glycolysis and is present in high concentrations in the cell, making it is unlikely to be a limiting factor in UDPGA synthesis. UDP is added to G1P to form UDP-glucose which is then dehydrogenated to form UDPGA. The basic reaction is<p><b>UDP-Glucuronate + acceptor -> UDP + acceptor-beta-D-glucuronide</b></p>The effect of this conjugation is to confer polarity to the substrate which can then be easily excreted in urine or bile. Functional groups acted on include hydroxyl, carboxylate, amino and sulfate groups. There are 2 families of UGTs, UGT1 and UGT2 which are further sub-divided into 3 subfamilies, UGT1A, UGT2A and UGT2B. There are more than 26 different isozymes in humans, of which 18 are functional proteins. They are composed of 527-530 residues and have a molecular weight of 50-57KDa.<br>The UGT1 family comprises of 9 proteins (UGT1A1, 1A3-1A10) but only 5 have been isolated in humans. Example substrates which are glucuronidated are acetaminophen by UGT1A6 and bilirubin by UGT1A1. Members of the UGT2 subfamily are each encoded by their own genes, in contrast to UGT1As which are encoded at the UGT1 locus. Example substrates are morphine conjugation by UGT2B7 and androgenic steroid conjugation by UGT2B17.<br>Xenobiotics conjugated with glucuronic acid can be substrates for beta-glucuronidase, an enzyme common in gut microflora. This enzyme can release the parent or phase I metabolite which can be reabsorbed. It can then either re-exert it's original effects or be conjugated by glucuronic acid again. This cycle is called <i>enterohepatic circulation</i> and can delay the elimination of the xenobiotic.10836148Pubmed2000Human UDP-glucuronosyltransferases: metabolism, expression, and diseaseTukey, RHStrassburg, CPAnnu Rev Pharmacol Toxicol 40:581-61614977861Pubmed2004Glucuronidation and the UDP-glucuronosyltransferases in health and diseaseWells, PGMackenzie, PIChowdhury, JRGuillemette, CGregory, PAIshii, YHansen, AJKessler, FKKim, PMChowdhury, NRRitter, JKDrug Metab Dispos 32:281-90Cytosolic sulfonation of small moleculesThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Transport and synthesis of PAPSThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>LEFT-TO-RIGHTSLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosolThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>SO4(2-)inorganic sulfatesulfateSulphateReactome DB_ID: 427648extracellular regionGENE ONTOLOGYGO:0005576sulfate [ChEBI:16189]sulfateChEBICHEBI:16189Reactome Database ID Release 72427648Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=427648ReactomeR-ALL-4276483Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-427648.3H+hydronReactome DB_ID: 351626Reactome Database ID Release 72351626Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=351626ReactomeR-ALL-3516264Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-351626.42SO4(2-)inorganic sulfatesulfateSulphateReactome DB_ID: 174375Reactome Database ID Release 72174375Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=174375ReactomeR-ALL-1743753Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-174375.32ACTIVATIONConverted from EntitySet in ReactomeSLC26A1,2Sulfate transportersReactome DB_ID: 9931254F1P5Z8SLC26A1SLC26A1Reactome DB_ID: 9931248plasma membraneGENE ONTOLOGYGO:0005886UniProt:F1P5Z8SLC26A1UniProtF1P5Z81EQUAL701EQUALReactome Database ID Release 729931248Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9931248ReactomeR-CFA-4275801Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-427580.1E2RJP2SLC26A2SLC26A2Reactome DB_ID: 9931252UniProt:E2RJP2SLC26A2UniProtE2RJP21EQUAL739EQUALReactome Database ID Release 729931252Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9931252ReactomeR-CFA-4276691Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-427669.1Reactome Database ID Release 729931254Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9931254ReactomeR-CFA-4276321Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-427632.1GENE ONTOLOGYGO:0015116Reactome Database ID Release 729931255Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9931255Reactome Database ID Release 729931257Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9931257ReactomeR-CFA-4275551Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-427555.1The SLC26A1 and 2 genes encode proteins that facilitate sulfate (SO4(2-)) uptake into cells (Alper & Sharma 2013). The mechanism by which these transporters work is unclear but may be enhanced by extracellular halides or acidic pH environments, cotransporting protons electroneutrally. Both can transport SO4(2-) (as well as oxalate and Cl-) across the basolateral membrane of epithelial cells. SLC26A1 encodes the sulfate anion transporter 1 (SAT1) (Regeer et al. 2003) and is most abundantly expressed in the liver and kidney, with lower levels expressed in many other parts of the body. SLC26A2 is ubiquitously expressed and encodes a sulfate transporter (Diastrophic dysplasia protein, DTD, DTDST) (Hastbacka et al. 1994). This transporter provides sulfate for sulfation of glycosaminoglycan chains in proteoglycans needed for cartilage development. Defects in SLC26A2 are implicated in the pathogenesis of several human chondrodysplasias.7923357Pubmed1994The diastrophic dysplasia gene encodes a novel sulfate transporter: positional cloning by fine-structure linkage disequilibrium mappingde la Chapelle, AMahtani, MMClines, GReeve-Daly, MPDaly, MHamilton, BAKusumi, KTrivedi, BWeaver, ACell 78:1073-8712713736Pubmed2003Characterization of the human sulfate anion transporter (hsat-1) protein and gene (SAT1; SLC26A1)Regeer, RRLee, AMarkovich, DDNA Cell Biol 22:107-1723506885Pubmed2013The SLC26 gene family of anion transporters and channelsAlper, Seth LSharma, Alok KMol. Aspects Med. 34:494-515LEFT-TO-RIGHT2.7.7.4Activation of inorganic sulfate forms APSPAPSS1,2 transfer SO4(2-) group to ATP to form APSATP + sulfate => adenylyl sulfate (APS) + pyrophosphateThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>ATPAdenosine 5'-triphosphateATP(4-)Reactome DB_ID: 113592ATP(4-) [ChEBI:30616]ATP(4-)ATPatpAdenosine 5'-triphosphateChEBICHEBI:30616Reactome Database ID Release 72113592Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113592ReactomeR-ALL-1135924Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-113592.4APSAdenosine 5'-phosphosulfate5'-adenylyl sulfateReactome DB_ID: 1743705'-adenylyl sulfate [ChEBI:17709]5'-adenylyl sulfateChEBICHEBI:17709Reactome Database ID Release 72174370Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=174370ReactomeR-ALL-1743703Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-174370.3ACTIVATIONConverted from EntitySet in ReactomePAPSS1,2Bifunctional PAPS synthetases 1,2Reactome DB_ID: 9914027PAPSS1PAPSS1E2QZ13Reactome DB_ID: 9914021UniProt:E2QZ13PAPSS1UniProtE2QZ131EQUAL624EQUALReactome Database ID Release 729914021Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914021ReactomeR-CFA-1743871Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-174387.1PAPSS2PAPSS2E2R1E3Reactome DB_ID: 9914025UniProt:E2R1E3PAPSS2UniProtE2R1E31EQUAL614EQUALReactome Database ID Release 729914025Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914025ReactomeR-CFA-30090481Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-3009048.1Reactome Database ID Release 729914027Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914027ReactomeR-CFA-1744001Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-174400.1GENE ONTOLOGYGO:0004781Reactome Database ID Release 729914046Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914046Reactome Database ID Release 729914048Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914048ReactomeR-CFA-1743921Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-174392.1In the first step of PAPS biosynthesis, ATP and sulfate react to form adenylyl sulfate (APS) and pyrophosphate (PPi), catalyzed by the ATP sulfurylase domains of the bifunctional enzymes PAPS synthases 1 and 2 (PAPSS1 and 2). PAPSS2 is essential for the sulfation of glycosaminoglycan chains in proteoglycans, a necessary post translational modification. Defective PAPSS2 results in undersulfation of the glycosaminoglycan chains in proteoglycans which causes spondyloepimetaphyseal dysplasia Pakistani type (SEMD PA; MIM:612847), a bone disease characterized by epiphyseal dysplasia with mild metaphyseal abnormalities. Mutations resulting in SEMD PA include S438*, T48R and R329* (Ahmad et al. 1998, ul Haque et al. 1998, Noordam et al. 2009).9771708Pubmed1998Mutations in orthologous genes in human spondyloepimetaphyseal dysplasia and the brachymorphic mouseul Haque, MFKing, LMKrakow, DCantor, RMRusiniak, MESwank, RTSuperti-Furga, AHaque, SAbbas, HAhmad, WAhmad, MCohn, DHNat Genet 20:157-629576487Pubmed1998Sulfation in high endothelial venules: cloning and expression of the human PAPS synthetaseGirard, JPBaekkevold, ESAmalric, FFASEB J 12:603-129668121Pubmed1998Molecular cloning, expression, and characterization of human bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase and its functional domainsVenkatachalam, KVAkita, HStrott, CAJ Biol Chem 273:19311-20LEFT-TO-RIGHT2.7.1.25adenylyl sulfate (APS) + ATP => PAPS + ADPPAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPSAPS reacts with another ATP molecule to form PAPSThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>ADPAdenosine 5'-diphosphateADP(3-)Reactome DB_ID: 29370ADP(3-) [ChEBI:456216]ADP(3-)ADP5&apos;-O-[(phosphonatooxy)phosphinato]adenosineADP trianionChEBICHEBI:456216Reactome Database ID Release 7229370Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29370ReactomeR-ALL-293704Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29370.4PAPS3'-phospho-5'-adenylyl sulfateReactome DB_ID: 1584713'-phospho-5'-adenylyl sulfate [ChEBI:17980]3'-phospho-5'-adenylyl sulfateChEBICHEBI:17980Reactome Database ID Release 72158471Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=158471ReactomeR-ALL-1584713Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-158471.3ACTIVATIONGENE ONTOLOGYGO:0004020Reactome Database ID Release 729914028Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914028Reactome Database ID Release 729914030Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914030ReactomeR-CFA-1743891Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-174389.1In the second step of PAPS biosynthesis, adenylyl sulfate (APS) is phosphorylated to 3'-phosphoadenylyl sulfate (PAPS), catalyzed by the APS kinase domains of the bifunctional enzymes PAPS synthases 1 and 2 (PAPSS1 and 2). PAPSS2 is essential for the sulfation of glycosaminoglycan chains of proteoglycans, a necessary post-translational modification. Defective PAPSS2 results in undersulfation of proteoglycans which causes spondyloepimetaphyseal dysplasia Pakistani type (SEMD-PA; MIM:612847), a bone disease characterized by epiphyseal dysplasia with mild metaphyseal abnormalities. Mutations resulting in SEMD-PA include S438*, T48R and R329* (Ahmad et al. 1998, ul Haque et al. 1998, Noordam et al. 2009).LEFT-TO-RIGHTSLC35B2,3 transport cytosolic PAPS to Golgi lumenThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>PAPS3'-phospho-5'-adenylyl sulfateReactome DB_ID: 741440Golgi lumenGENE ONTOLOGYGO:0005796Reactome Database ID Release 72741440Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=741440ReactomeR-ALL-7414403Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-741440.3ACTIVATIONConverted from EntitySet in ReactomePAPST1,2SLC35B2,3Reactome DB_ID: 9935951J9NY30SLC35B2SLC35B2Reactome DB_ID: 9935945Golgi membraneGENE ONTOLOGYGO:0000139UniProt:J9NY30SLC35B2UniProtJ9NY301EQUAL432EQUALReactome Database ID Release 729935945Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9935945ReactomeR-CFA-7414541Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-741454.1E2RJI8SLC35B3SLC35B3Reactome DB_ID: 9935949UniProt:E2RJI8SLC35B3UniProtE2RJI81EQUAL401EQUALReactome Database ID Release 729935949Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9935949ReactomeR-CFA-34656101Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-3465610.1Reactome Database ID Release 729935951Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9935951ReactomeR-CFA-34656111Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-3465611.1GENE ONTOLOGYGO:0046964Reactome Database ID Release 729935952Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9935952Reactome Database ID Release 729935954Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9935954ReactomeR-CFA-7414491Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-741449.1The human gene SLC35B2 encodes the adenosine 3'-phospho 5'-phosphosulfate transporter 1 (PAPST1) (Ozeran et al. 1996, Kamiyama et al. 2003). In human tissues, PAPST1 is highly expressed in the placenta and pancreas and present at lower levels in the colon and heart. The human gene SLC35B3 encodes a human PAPS transporter gene that is closely related to PAPST1. Called PAPST2, it is predominantly expressed in the colon (Kamiyama et al. 2006). Both proteins can transport PAPS from the cytosol to the Golgi lumen.8619989Pubmed1996Identification and partial purification of PAPS translocaseOzeran, JDWestley, JSchwartz, NBBiochemistry 35:3695-70316492677Pubmed2006Molecular cloning and characterization of a novel 3'-phosphoadenosine 5'-phosphosulfate transporter, PAPST2Kamiyama, SSasaki, NGoda, EUi-Tei, KSaigo, KNarimatsu, HJigami, YKannagi, RIrimura, TNishihara, SJ Biol Chem 281:10945-5312716889Pubmed2003Molecular cloning and identification of 3'-phosphoadenosine 5'-phosphosulfate transporterKamiyama, SSuda, TUeda, RSuzuki, MOkubo, RKikuchi, NChiba, YGoto, SToyoda, HSaigo, KWatanabe, MNarimatsu, HJigami, YNishihara, SJ Biol Chem 278:25958-63Reactome Database ID Release 729997615Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9997615ReactomeR-CFA-1743621Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-174362.1GENE ONTOLOGYGO:0050428PAPS (3'-phosphoadenosine-5'-phosphosulfate), which functions as a sulfate donor in the cell, is synthesized from sulfate and two molecules of ATP in a two-step process (Robbins & Lipmann 1958) catalyzed in vertebrates by a bifunctional enzyme (Venkatachalam et al. 1998). PAPS synthesis takes place in the cytosol, and it is either consumed there in the sulfonation of a variety of hormones and xenobiotics, or it is transported to the Golgi apparatus and consumed in the synthesis of proteoglycans like chondroitin sulfate. Two isoforms of the human bifunctional enzyme are known, mutations in one of which are associated with defects in proteoglycan biosynthesis (Girard et al. 1998, ul Haque et al. 1998).13575436Pubmed1958Separation of the two enzymatic phases in active sulfate synthesisRobbins, PWLipmann, FJ Biol Chem 233:681-5LEFT-TO-RIGHT2.8.2.1SULT1A1 dimer sulfonates PARA to PARA-SO4Acetaminophen can form an O- sulfate conjugateThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>PARAAcetaminophen (TN TYLENOL)paracetamolReactome DB_ID: 158469Reactome Database ID Release 72158469Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=158469ReactomeR-ALL-1584694Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-158469.4PARA-SO4Acetaminophen O-sulfate conjugateparacetamol sulfateReactome DB_ID: 158472paracetamol sulfate [ChEBI:32635]paracetamol sulfateChEBICHEBI:32635Reactome Database ID Release 72158472Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=158472ReactomeR-ALL-1584724Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-158472.4PAPadenosine 3',5'-bisphosphateadenosine 3',5'-bismonophosphateReactome DB_ID: 158466adenosine 3',5'-bismonophosphate [ChEBI:17985]adenosine 3',5'-bismonophosphateChEBICHEBI:17985Reactome Database ID Release 72158466Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=158466ReactomeR-ALL-1584663Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-158466.3ACTIVATIONSULT1A1 dimerReactome DB_ID: 9910734Q29476SULT1A1SULT1A1Reactome DB_ID: 9910732UniProt:Q29476SULT1A1UniProtQ294761EQUAL295EQUALReactome Database ID Release 729910732Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9910732ReactomeR-CFA-1584741Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-158474.12Reactome Database ID Release 729910734Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9910734ReactomeR-CFA-1584731Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-158473.1GENE ONTOLOGYGO:0004062Reactome Database ID Release 729910735Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9910735Reactome Database ID Release 729910737Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9910737ReactomeR-CFA-1584681Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-158468.1Cytosolic sulfotransferase 1A1 (SULT1A1), in dimeric form, can sulfonate the widely used analgesic and antipyretic drug paracetamol (PARA aka acetaminophen). Around 20-30% of PARA is metabolised via sulfonation by the liver (Parkinson 1995, Yamazoe et al. 1995, Strott 2002).10503886Pubmed1999Sulfotransferase catalyzing sulfation of heterocyclic aminesYamazoe, YNagata, KYoshinari, KFujita, KShiraga, TIwasaki, KCancer Lett 143:103-712372849Pubmed2002Sulfonation and molecular actionStrott, CAEndocr Rev 23:703-32LEFT-TO-RIGHT2.8.2.1SULT1A1 dimer sulfonates NHABPN-hydroxy-4-aminobiphenyl can form a sulfate conjugateThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>NHABPN-hydroxy-4-aminobiphenylReactome DB_ID: 158847Reactome Database ID Release 72158847Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=158847ReactomeR-ALL-1588473Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-158847.3NHABP-SO4N-hydroxy-4-aminobiphenyl O-sulfateReactome DB_ID: 158859N-hydroxy-4-aminobiphenyl O-sulfate [ChEBI:32701]N-hydroxy-4-aminobiphenyl O-sulfateChEBICHEBI:32701Reactome Database ID Release 72158859Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=158859ReactomeR-ALL-1588594Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-158859.4ACTIVATIONReactome Database ID Release 729910791Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9910791ReactomeR-CFA-1588601Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-158860.1N-hydroxy-4-aminobiphenyl (NHABP) is a genotoxic metabolite of an industrial carcinogen no longer used in the rubber industry. It can be sulfonated in the liver by cytosolic sulfotransferase 1A1 (SULT1A1) (Yamazoe et al. 1999, Weinshilboum et al. 1997, Strott 2002).
9034160Pubmed1997Sulfation and sulfotransferases 1: Sulfotransferase molecular biology: cDNAs and genesWeinshilboum, RMOtterness, DMAksoy, IAWood, TCHer, CRaftogianis, RBFASEB J 11:3-14LEFT-TO-RIGHT2.8.2.1Phenol can form a sulfate conjugateThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>PhOHBenzenolphenolHydroxybenzenePhenic acidPhenylic acidReactome DB_ID: 158858Reactome Database ID Release 72158858Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=158858ReactomeR-ALL-1588583Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-158858.3Phenyl sulfatephenyl hydrogen sulfateReactome DB_ID: 158850phenyl hydrogen sulfate [ChEBI:27905]phenyl hydrogen sulfateChEBICHEBI:27905Reactome Database ID Release 72158850Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=158850ReactomeR-ALL-1588503Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-158850.3ACTIVATIONReactome Database ID Release 729910789Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9910789ReactomeR-CFA-1588491Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-158849.1At the beginning of this reaction, 1 molecule of 'PAPS', and 1 molecule of 'Phenol' are present. At the end of this reaction, 1 molecule of 'Phenyl sulfate', and 1 molecule of 'PAP' are present.<br><br> This reaction takes place in the 'cytosol' and is mediated by the 'aryl sulfotransferase activity' of 'SULT1A1 homodimer'.<br>LEFT-TO-RIGHT2.8.2.1SULT1A3,4 dimers sulfate DA to DAOSDopamine can form an O-sulfate conjugateThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>DAdopamineReactome DB_ID: 159362dopamine [ChEBI:18243]dopamineChEBICHEBI:18243Reactome Database ID Release 72159362Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=159362ReactomeR-ALL-1593623Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-159362.3DAOSdopamine 3-O-sulfateReactome DB_ID: 159352dopamine 3-O-sulfate [ChEBI:37946]dopamine 3-O-sulfateChEBICHEBI:37946Reactome Database ID Release 72159352Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=159352ReactomeR-ALL-1593523Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-159352.3ACTIVATIONReactome Database ID Release 729910864Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9910864ReactomeR-CFA-1593581Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-159358.1The catecholamine neurotransmitter dopamine (DA) is predominantly (>95%) conjugated with sulfate (dopamine 3-O-sulfate, DAOS) in human blood circulation. Human SULT1A3 and SULT1A4 are the major sulfotransferases that sulfonate DA (as well as other catecholamines and phenols) (Reiter et al. 1983, Johnson et al. 1980, Thomae et al. 2003, Hildebrandt et al. 2004).6139755Pubmed1983Thermolabile and thermostable human platelet phenol sulfotransferase. Substrate specificity and physical separation.Reiter, CMwaluko, GDunnette, JVan Loon, JWeinshilboum, RMNaunyn Schmiedebergs Arch Pharmacol 324:140-715358107Pubmed2004Human SULT1A3 pharmacogenetics: gene duplication and functional genomic studiesHildebrandt, Michelle A TSalavaggione, Oreste EMartin, Yvette NFlynn, Heather CJalal, SyedWieben, Eric DWeinshilboum, RMBiochem. Biophys. Res. Commun. 321:870-814622112Pubmed2003Human catecholamine sulfotransferase (SULT1A3) pharmacogenetics: functional genetic polymorphismThomae, Bianca ARifki, Oktay FTheobald, Michelle AEckloff, Bruce WWieben, Eric DWeinshilboum, RMJ. Neurochem. 87:809-196770210Pubmed1980Radioenzymatic assay of sulfate conjugates of catecholamines and DOPA in plasmaJohnson, GABaker, CASmith, RTLife Sci 26:1591-8LEFT-TO-RIGHT2.8.2.13,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAPThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>3,3'-diiodothyronineReactome DB_ID: 1764863,3'-diiodothyronine [ChEBI:35430]3,3'-diiodothyronineChEBICHEBI:35430Reactome Database ID Release 72176486Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=176486ReactomeR-ALL-1764862Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-176486.23,3'-diiodothyronine 4-sulfate3,3'-diiodo-L-thyronine sulfateReactome DB_ID: 1765193,3'-diiodo-L-thyronine sulfate [ChEBI:35431]3,3'-diiodo-L-thyronine sulfateChEBICHEBI:35431Reactome Database ID Release 72176519Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=176519ReactomeR-ALL-1765193Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-176519.3ACTIVATIONConverted from EntitySet in ReactomeSULT dimers (T2)Reactome DB_ID: 9914532SULT1B1 dimerReactome DB_ID: 9914512Q95JD5SULT1B1SULT1B1Reactome DB_ID: 9914510UniProt:Q95JD5SULT1B1UniProtQ95JD51EQUAL296EQUALReactome Database ID Release 729914510Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914510ReactomeR-CFA-1765511Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-176551.12Reactome Database ID Release 729914512Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914512ReactomeR-CFA-1764951Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-176495.1SULT1C1 dimerReactome DB_ID: 9914518E2RAL3SULT1C2SULT1C2Reactome DB_ID: 9914516UniProt:E2RAL3SULT1C2UniProtE2RAL31EQUAL296EQUALReactome Database ID Release 729914516Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914516ReactomeR-CFA-29808651Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2980865.12Reactome Database ID Release 729914518Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914518ReactomeR-CFA-1765141Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-176514.1SULT1E1 dimerReactome DB_ID: 9914524F1Q1N2LOC482182SULT1E1Reactome DB_ID: 9914522UniProt:F1Q1N2LOC482182UniProtF1Q1N21EQUAL294EQUALReactome Database ID Release 729914522Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914522ReactomeR-CFA-1765301Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-176530.12Reactome Database ID Release 729914524Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914524ReactomeR-CFA-1766451Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-176645.1SULT6B1 dimerReactome DB_ID: 9914530J9P2M5SULT6B1Reactome DB_ID: 9914528UniProt:J9P2M5UniProtJ9P2M51EQUAL303EQUALReactome Database ID Release 729914528Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914528ReactomeR-CFA-89599921Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-8959992.12Reactome Database ID Release 729914530Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914530ReactomeR-CFA-89599911Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-8959991.1Reactome Database ID Release 729914532Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914532ReactomeR-CFA-1766501Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-176650.1Reactome Database ID Release 729914533Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914533Reactome Database ID Release 729914535Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914535ReactomeR-CFA-1764741Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-176474.1Six SULT enzymes, SULT1A1 (Li et al. 2001), 1A3 (Kester, Kaptein et al. 1999), 1B1 (Wang et al. 1998), 1C1 (Li et al. 2000), 1E1 (Li and Anderson 1999; Kester, van Dijk et al. 1999), and 2A1 (Li and Anderson 1999), can catalyze the sulfonation of 3,3'-diiodothyronine (T2) in vitro or in tissue culture model systems. These six enzymes also catalyze the sulfonation of 3,5,3'-triiodothyronine (T3).11739018Pubmed2001Characterization of human liver thermostable phenol sulfotransferase (SULT1A1) allozymes with 3,3',5-triiodothyronine as the substrateLi, XClemens, DLCole, JRAnderson, RJJ Endocrinol 171:525-3211077054Pubmed2000Sulfation of iodothyronines by human sulfotransferase 1C1 (SULT1C1)*Li, XClemens, DLAnderson, RJBiochem Pharmacol 60:1713-610199779Pubmed1999Characterization of human iodothyronine sulfotransferasesKester, MHKaptein, ERoest, TJvan Dijk, CHTibboel, DMeinl, WGlatt, HCoughtrie, MWVisser, TJJ Clin Endocrinol Metab 84:1357-649463486Pubmed1998Expression and characterization of a novel thyroid hormone-sulfating form of cytosolic sulfotransferase from human liverWang, JFalany, JLFalany, CNMol Pharmacol 53:274-8210512730Pubmed1999Sulfation of iodothyronines by recombinant human liver steroid sulfotransferasesLi, XAnderson, RJBiochem Biophys Res Commun 263:632-9LEFT-TO-RIGHT2.8.2.13,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAPThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>T33,5,3'-triiodothyronine3,3',5'-triiodothyronineReactome DB_ID: 1766673,3',5'-triiodothyronine [ChEBI:28774]3,3',5'-triiodothyronineChEBICHEBI:28774Reactome Database ID Release 72176667Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=176667ReactomeR-ALL-1766674Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-176667.43,5,3'-triiodothyronine 4-sulfate3,3',5-triiodo-L-thyronine sulfateReactome DB_ID: 1765643,3',5-triiodo-L-thyronine sulfate [ChEBI:35432]3,3',5-triiodo-L-thyronine sulfateChEBICHEBI:35432Reactome Database ID Release 72176564Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=176564ReactomeR-ALL-1765643Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-176564.3ACTIVATIONConverted from EntitySet in ReactomeSULT dimers (T3)Reactome DB_ID: 9914560SULT4A1 dimerReactome DB_ID: 9914558E2QSW8SULT4A1SULT4A1Reactome DB_ID: 9914556UniProt:E2QSW8SULT4A1UniProtE2QSW81EQUAL284EQUALReactome Database ID Release 729914556Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914556ReactomeR-CFA-1766681Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-176668.12Reactome Database ID Release 729914558Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914558ReactomeR-CFA-1765401Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-176540.1Reactome Database ID Release 729914560Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914560ReactomeR-CFA-1765991Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-176599.1Reactome Database ID Release 729914561Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914561Reactome Database ID Release 729914563Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914563ReactomeR-CFA-1765851Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-176585.13,5,3'-Triiodothyronine (T3) 4-sulfate is a major metabolite of T3 in humans (LoPresti and Nicoloff 1994), and seven SULT enzymes, SULT1A1 (Li et al. 2001), 1A3 (Kester, Kaptein et al. 1999), 1B1 (Wang et al. 1998), 1C1 (Li et al. 2000), 1E1 (Li and Anderson 1999; Kester, van Dijk et al. 1999), 2A1 (Li and Anderson 1999), and 4A1 (Sakakibara et al. 2002) can catalyze this reaction in vitro or in tissue culture model systems. All of these enzymes except SULT4A1 also catalyze the sulfonation of 3,3'-diiodothyronine (T2).8126143Pubmed19943,5,3'-Triiodothyronine (T3) sulfate: a major metabolite in T3 metabolism in manLoPresti, JSNicoloff, JTJ Clin Endocrinol Metab 78:688-9212039030Pubmed2002Highly conserved mouse and human brain sulfotransferases: molecular cloning, expression, and functional characterizationSakakibara, YSuiko, MPai, TGNakayama, TTakami, YKatafuchi, JLiu, MCGene 285:39-47LEFT-TO-RIGHT3ABHD14B hydrolyses PNPBThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>PNPBp-nitrophenyl butyrateReactome DB_ID: 5695960p-nitrophenyl butyrate [ChEBI:85867]p-nitrophenyl butyrateChEBICHEBI:85867Reactome Database ID Release 725695960Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5695960ReactomeR-ALL-56959603Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-5695960.3PNPp-nitrophenol4-nitrophenolReactome DB_ID: 56959504-nitrophenol [ChEBI:16836]4-nitrophenolChEBICHEBI:16836Reactome Database ID Release 725695950Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5695950ReactomeR-ALL-56959503Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-5695950.3BUTButyratebutyric acidReactome DB_ID: 76179butyric acid [ChEBI:30772]butyric acidChEBICHEBI:30772Reactome Database ID Release 7276179Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=76179ReactomeR-ALL-761793Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-76179.3ACTIVATIONE2RLZ9ABHD14BABHD14BReactome DB_ID: 9975812UniProt:E2RLZ9ABHD14BUniProtE2RLZ92EQUAL210EQUALReactome Database ID Release 729975812Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9975812ReactomeR-CFA-56959941Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-5695994.1GENE ONTOLOGYGO:0016787Reactome Database ID Release 729975813Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9975813Reactome Database ID Release 729975815Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9975815ReactomeR-CFA-56959641Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-5695964.1Alpha/beta hydrolase domain-containing protein 14B (ABHD14B) can hydrolyse the model substrate p-nitrophenyl butyrate (PNPB) to p-nitrophenol (PNP) and butyric acid (BUT)<br>(Padmanabhan et al. 2004). Its physiological substrate is unknown.14672934Pubmed2004The crystal structure of CCG1/TAF(II)250-interacting factor B (CIB)Padmanabhan, BalasundaramKuzuhara, TakashiAdachi, NaruhikoHorikoshi, MasamiJ. Biol. Chem. 279:9615-24LEFT-TO-RIGHT2.8.2.1p-nitrophenol + PAPS => p-nitrophenol sulfate + PAPThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>p-nitrophenol sulfate4-nitrophenyl hydrogen sulfateReactome DB_ID: 1766004-nitrophenyl hydrogen sulfate [ChEBI:35422]4-nitrophenyl hydrogen sulfateChEBICHEBI:35422Reactome Database ID Release 72176600Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=176600ReactomeR-ALL-1766003Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-176600.3ACTIVATIONConverted from EntitySet in ReactomeSULT1A1,A2,C2,4A1SULT enzymes active on p-nitrophenolReactome DB_ID: 9914582SULT1C2 dimerReactome DB_ID: 9914580E2RAM9SULT1C4SULT1C4Reactome DB_ID: 9914578UniProt:E2RAM9SULT1C4UniProtE2RAM91EQUAL302EQUALReactome Database ID Release 729914578Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914578ReactomeR-CFA-1766161Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-176616.12Reactome Database ID Release 729914580Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914580ReactomeR-CFA-1765971Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-176597.1Reactome Database ID Release 729914582Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914582ReactomeR-CFA-1764791Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-176479.1Reactome Database ID Release 729914583Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914583Reactome Database ID Release 729914585Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914585ReactomeR-CFA-1766461Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-176646.1The sulfonation of the xenobiotic p-nitrophenol (4-nitrophenol) can be catalyzed by five well-characterized SULT enzymes, 1A1 (Brix et al. 1998), 1A2 (Brix et al. 1998; Zhu et al. 1996), 1C2 (Sakakibara et al. 1998), and 4A1 (Sakakibara et al. 2002).8697101Pubmed1996cDNA cloning and expression of a new form of human aryl sulfotransferaseZhu, XVeronese, MEIocco, PMcManus, MEInt J Biochem Cell Biol 28:565-719566739Pubmed1998Structural and functional characterisation of human sulfotransferasesBrix, LANicoll, RZhu, XMcManus, MEChem Biol Interact 109:123-79852044Pubmed1998Molecular cloning, expression, and characterization of novel human SULT1C sulfotransferases that catalyze the sulfonation of N-hydroxy-2-acetylaminofluoreneSakakibara, YYanagisawa, KKatafuchi, JRinger, DPTakami, YNakayama, TSuiko, MLiu, MCJ Biol Chem 273:33929-35LEFT-TO-RIGHT2.8.2N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAPThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>N-hydroxy-2-acetamidofluoreneN-hydroxy-2-acetylaminofluoreneReactome DB_ID: 176566N-hydroxy-2-acetamidofluorene [ChEBI:17931]N-hydroxy-2-acetamidofluoreneChEBICHEBI:17931Reactome Database ID Release 72176566Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=176566ReactomeR-ALL-1765663Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-176566.3AAF-N-S2-acetylaminofluorene-N-sulfate2-acetamidofluorene N-sulfateReactome DB_ID: 1765002-acetamidofluorene N-sulfate [ChEBI:35424]2-acetamidofluorene N-sulfateChEBICHEBI:35424Reactome Database ID Release 72176500Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=176500ReactomeR-ALL-1765003Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-176500.3ACTIVATIONConverted from EntitySet in ReactomeSULTs active on NH2AAFReactome DB_ID: 9914590Reactome Database ID Release 729914590Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914590ReactomeR-CFA-1765721Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-176572.1GENE ONTOLOGYGO:0008146Reactome Database ID Release 729914591Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914591Reactome Database ID Release 729914593Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914593ReactomeR-CFA-1766691Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-176669.1Sulfonation of the xenobiotic N-hydroxy-2-acetylaminofluorene converts it to a potent carcinogen. SULT1A2 (Glatt 2000) and SULT1C1 and 1C2 (Sakakibara et al. 1998) catalyze this reaction.11154739Pubmed2000Sulfotransferases in the bioactivation of xenobioticsGlatt, HChem Biol Interact 129:141-70LEFT-TO-RIGHT2.8.2.2cholesterol + PAPS => cholesterol sulfate + PAPThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>CHOLcholesterolReactome DB_ID: 176478cholesterol [ChEBI:16113]cholesterolcholest-5-en-3beta-olChEBICHEBI:16113Reactome Database ID Release 72176478Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=176478ReactomeR-ALL-1764783Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-176478.3cholesterol sulfateReactome DB_ID: 176618cholesterol sulfate [ChEBI:41321]cholesterol sulfateChEBICHEBI:41321Reactome Database ID Release 72176618Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=176618ReactomeR-ALL-1766182Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-176618.2ACTIVATIONSULT2B1-2 dimerReactome DB_ID: 9914541F1P781SULT2B1SULT2B1-2Reactome DB_ID: 9914539UniProt:F1P781SULT2B1UniProtF1P7811EQUAL365EQUALReactome Database ID Release 729914539Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914539ReactomeR-CFA-1766301Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-176630.12Reactome Database ID Release 729914541Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914541ReactomeR-CFA-1766591Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-176659.1GENE ONTOLOGYGO:0004027Reactome Database ID Release 729914542Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914542Reactome Database ID Release 729914572Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914572ReactomeR-CFA-1766091Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-176609.1The 3-hydroxyl groups of a number of sterols can undergo sulfonation. Cholesterol sulfate is particularly abundant in the body, and may have both regulatory and biosynthetic functions (Strott and Higashi 2003). Its synthesis is catalyzed by the b isoform of SULT2B1 (Fuda et al. 2002; Javitt et al. 2001).11416019Pubmed2001Cholesterol and hydroxycholesterol sulfotransferases: identification, distinction from dehydroepiandrosterone sulfotransferase, and differential tissue expressionJavitt, NBLee, YCShimizu, CFuda, HStrott, CAEndocrinology 142:2978-8412730293Pubmed2003Cholesterol sulfate in human physiology: what's it all about?Strott, CAHigashi, YJ Lipid Res 44:1268-7812145317Pubmed2002Mutational analysis of human hydroxysteroid sulfotransferase SULT2B1 isoforms reveals that exon 1B of the SULT2B1 gene produces cholesterol sulfotransferase, whereas exon 1A yields pregnenolone sulfotransferaseFuda, HLee, YCShimizu, CJavitt, NBStrott, CAJ Biol Chem 277:36161-6LEFT-TO-RIGHT2.8.2.2SULTs transfer (SO4)2- group to 27HCHOL27-hydroxycholesterol + PAPS => 27-hydroxycholesterol 3-sulfate + PAPThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>27HCHOL27-hydroxycholesterol26-hydroxycholesterolReactome DB_ID: 17661726-hydroxycholesterol [ChEBI:17703]26-hydroxycholesterolChEBICHEBI:17703Reactome Database ID Release 72176617Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=176617ReactomeR-ALL-1766173Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-176617.327HCHOL3S27-hydroxycholesterol 3-sulfate26-hydroxycholesterol 3-sulfateReactome DB_ID: 17650226-hydroxycholesterol 3-sulfate [ChEBI:35419]26-hydroxycholesterol 3-sulfateChEBICHEBI:35419Reactome Database ID Release 72176502Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=176502ReactomeR-ALL-1765023Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-176502.3ACTIVATIONReactome Database ID Release 729914544Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914544ReactomeR-CFA-1764941Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-176494.1The sulfonation of 27-hydroxycholesterol (27HCHOL) is catalyzed by both the a and b isoforms of SULT2B1 (Javitt et al. 2001).LEFT-TO-RIGHT2.8.2.15SULTs transfer (SO4)2- group to PREGpregnenolone + PAPS => pregnenolone sulfate + PAPThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>PREGpregnenoloneReactome DB_ID: 193103pregnenolone [ChEBI:16581]pregnenoloneChEBICHEBI:16581Reactome Database ID Release 72193103Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=193103ReactomeR-ALL-1931033Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-193103.3PREGSpregnenolone sulfateReactome DB_ID: 176665pregnenolone sulfate [ChEBI:35420]pregnenolone sulfateChEBICHEBI:35420Reactome Database ID Release 72176665Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=176665ReactomeR-ALL-1766653Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-176665.3ACTIVATIONConverted from EntitySet in ReactomeSULTs active on pregnenoloneReactome DB_ID: 9914546Reactome Database ID Release 729914546Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914546ReactomeR-CFA-1765671Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-176567.1GENE ONTOLOGYGO:0050294Reactome Database ID Release 729914547Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914547Reactome Database ID Release 729914549Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914549ReactomeR-CFA-1765171Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-176517.1The sulfonation of pregnenolone (PREG) is catalyzed by both the a and b isoforms of SULT2B1, although the a isoform is more active in assays in vitro (Fuda et al. 2002; Meloche and Falany 2001).11457664Pubmed2001Expression and characterization of the human 3 beta-hydroxysteroid sulfotransferases (SULT2B1a and SULT2B1b)Meloche, CAFalany, CNJ Steroid Biochem Mol Biol 77:261-9LEFT-TO-RIGHT2.8.2.4estrone + PAPS => estrone 3-sulfate + PAPThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>E1estroneReactome DB_ID: 176575estrone [ChEBI:17263]estroneChEBICHEBI:17263Reactome Database ID Release 72176575Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=176575ReactomeR-ALL-1765753Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-176575.3E1Sestrone 3-sulfateReactome DB_ID: 176501estrone 3-sulfate [ChEBI:17474]estrone 3-sulfateChEBICHEBI:17474Reactome Database ID Release 72176501Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=176501ReactomeR-ALL-1765013Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-176501.3ACTIVATIONGENE ONTOLOGYGO:0004304Reactome Database ID Release 729914586Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914586Reactome Database ID Release 729914588Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914588ReactomeR-CFA-1766641Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-176664.1Sulfonation of estrone is catalyzed by SULT1E1 (Aksoy et al. 1994; Falany et al. 1995), and also by SULT2A1 (Comer et al. 1993), although the efficiency of SULT2A1 catalysis is unknown.7779757Pubmed1995Bacterial expression and characterization of a cDNA for human liver estrogen sulfotransferaseFalany, CNKrasnykh, VFalany, JLJ Steroid Biochem Mol Biol 52:529-397678732Pubmed1993Cloning and expression of human liver dehydroepiandrosterone sulphotransferaseComer, KAFalany, JLFalany, CNBiochem J 289:233-408185618Pubmed1994Human liver estrogen sulfotransferase: identification by cDNA cloning and expressionAksoy, IAWeinshilboum, RMWood, TCBiochem Biophys Res Commun 200:1621-9LEFT-TO-RIGHT2.8.2.15dehydroepiandrosterone (DHEA) + PAPS => DHEA sulfate + PAPThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>DHEAdehydroepiandrosteroneReactome DB_ID: 176626dehydroepiandrosterone [ChEBI:28689]dehydroepiandrosteroneChEBICHEBI:28689Reactome Database ID Release 72176626Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=176626ReactomeR-ALL-1766263Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-176626.3DHEA-SO4dehydroepiandrosterone sulfateReactome DB_ID: 176496dehydroepiandrosterone sulfate [ChEBI:16814]dehydroepiandrosterone sulfateChEBICHEBI:16814Reactome Database ID Release 72176496Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=176496ReactomeR-ALL-1764963Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-176496.3ACTIVATIONReactome Database ID Release 729914574Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914574ReactomeR-CFA-1766311Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-176631.1Sulfonation of dehydroepiandrosterone (DHEA) is catalyzed by SULT1E1 (Aksoy et al. 1994), SULT2A1 (Radominska et al. 1990) and the a and b isoforms of SULT2B1 (Meloche and Falany 2001).2268288Pubmed1990Human liver steroid sulphotransferase sulphates bile acidsRadominska, AComer, KAZimniak, PFalany, JLIscan, MFalany, CNBiochem J 272:597-604LEFT-TO-RIGHT2.8.2.15beta-estradiol + PAPS => beta-estradiol 3-sulfate + PAPThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>E2beta-estradiol17beta-estradiolReactome DB_ID: 17661917beta-estradiol [ChEBI:16469]17beta-estradiolChEBICHEBI:16469Reactome Database ID Release 72176619Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=176619ReactomeR-ALL-1766193Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-176619.3E2-SO4beta-estradiol 3-sulfate17beta-estradiol 3-sulfateReactome DB_ID: 17649217beta-estradiol 3-sulfate [ChEBI:4866]17beta-estradiol 3-sulfateChEBICHEBI:4866Reactome Database ID Release 72176492Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=176492ReactomeR-ALL-1764923Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-176492.3ACTIVATIONReactome Database ID Release 729914550Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914550Reactome Database ID Release 729914552Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914552ReactomeR-CFA-1765211Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-176521.1Sulfonation of beta-estradiol is catalyzed by SULT1E1 (Falany et al. 1995).LEFT-TO-RIGHT3.1.3.7Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphateThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>PiOrthophosphatephosphate(3-)PhosphateInorganic PhosphateReactome DB_ID: 29372phosphate(3-) [ChEBI:18367]phosphate(3-)ChEBICHEBI:18367Reactome Database ID Release 7229372Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29372ReactomeR-ALL-293723Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29372.3AMPadenosine 5'-monophosphateAdenylic acidAdenylate5'-AMP5'-Adenylic acid5'-Adenosine monophosphateAdenosine 5'-phosphateReactome DB_ID: 76577adenosine 5'-monophosphate [ChEBI:16027]adenosine 5'-monophosphateChEBICHEBI:16027Reactome Database ID Release 7276577Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=76577ReactomeR-ALL-765774Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-76577.4ACTIVATIONBPNT1BPNT1J9P1R5Reactome DB_ID: 9914567UniProt:J9P1R5BPNT1UniProtJ9P1R52EQUAL308EQUALReactome Database ID Release 729914567Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914567ReactomeR-CFA-1765731Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-176573.1GENE ONTOLOGYGO:0008441Reactome Database ID Release 729914568Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914568Reactome Database ID Release 729914570Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914570ReactomeR-CFA-1766061Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-176606.1GENE ONTOLOGYGO:0050427PAP is generated as a byproduct of sulfonation reactions in vivo; its hydrolysis to AMP and orthophosphate returns its constituents to the pool of molecules available for cytosolic nucleotide metabolism. Bisphosphate 3'-nucleotidase 1catalyzes this reaction efficiently in vitro; whether other nucleotidases also play a role in PAP breakdown in vivo is unknown.10224133Pubmed1999Cloning and characterization of a mammalian lithium-sensitive bisphosphate 3'-nucleotidase inhibited by inositol 1,4-bisphosphateSpiegelberg, BDXiong, JPSmith, JJGu, RFYork, JDJ Biol Chem 274:13619-28LEFT-TO-RIGHT2.8.2.20TPST1,2 transfer SO4(2-) from PAPS to PODXL2This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>2PODXL2PODXL2J9P5W1Reactome DB_ID: 9992731UniProt:J9P5W1PODXL2UniProtJ9P5W133EQUAL605EQUALReactome Database ID Release 729992731Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9992731ReactomeR-CFA-89542481Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-8954248.1PODXL2OSulf-Y97,118-PODXL2J9P5W1Reactome DB_ID: 999273597EQUALO4'-sulfo-L-tyrosineMODMOD:00181118EQUAL33EQUAL605EQUALReactome Database ID Release 729992735Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9992735ReactomeR-CFA-89542731Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-8954273.1PAPadenosine 3',5'-bisphosphateadenosine 3',5'-bismonophosphateReactome DB_ID: 742343Reactome Database ID Release 72742343Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=742343ReactomeR-ALL-7423433Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-742343.32ACTIVATIONConverted from EntitySet in ReactomeTPST1,2Reactome DB_ID: 9992745TPST1TPST1J9NYB3Reactome DB_ID: 9992739UniProt:J9NYB3TPST1UniProtJ9NYB31EQUAL370EQUALReactome Database ID Release 729992739Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9992739ReactomeR-CFA-89542531Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-8954253.1TPST2TPST2F1P7K8Reactome DB_ID: 9992743UniProt:F1P7K8TPST2UniProtF1P7K81EQUAL377EQUALReactome Database ID Release 729992743Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9992743ReactomeR-CFA-89542501Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-8954250.1Reactome Database ID Release 729992745Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9992745ReactomeR-CFA-89542651Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-8954265.1GENE ONTOLOGYGO:0008476Reactome Database ID Release 729992746Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9992746Reactome Database ID Release 729992748Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9992748ReactomeR-CFA-89542621Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-8954262.1Podocalyxin-like protein 2 (PODXL2 aka endoglycan) acts as a ligand for vascular selectins which mediate the rapid rolling of leukocytes over vascular surfaces. PODXL2 interacts with selectins through sulfation on two tyrosine residues (97 and 118) (Fieger et al. 2003, Kerr et al. 2008) and O-linked carbohydrate structures within its acidic amino-terminal region (latter not shown here). Protein-tyrosine sulfotransferases 1 and 2 (TPST1 and TPST2) are Golgi membrane-resident proteins which catalyse the transfer of sulfate from 3'-phospho-5'-adenylyl sulfate (PAPS) to tyrosine residues within acidic motifs of polypeptides such as PODXL2 (Ouyang et al. 1998, Danan et al. 2008, Teramoto et al. 2013).18672380Pubmed2008Mass spectrometric kinetic analysis of human tyrosylprotein sulfotransferase-1 and -2Danan, Lieza MYu, ZhihaoHoffhines, Adam JMoore, Kevin LLeary, Julie AJ. Am. Soc. Mass Spectrom. 19:1459-6618606703Pubmed2008Endoglycan, a member of the CD34 family of sialomucins, is a ligand for the vascular selectinsKerr, Sheena CFieger, Claudia BSnapp, Karen RRosen, Steven DJ. Immunol. 181:1480-9012889478Pubmed2003Endoglycan, a member of the CD34 family, functions as an L-selectin ligand through modification with tyrosine sulfation and sialyl Lewis xFieger, Claudia BSassetti, Christopher MRosen, Steven DJ. Biol. Chem. 278:27390-89501187Pubmed1998Tyrosylprotein sulfotransferase: purification and molecular cloning of an enzyme that catalyzes tyrosine O-sulfation, a common posttranslational modification of eukaryotic proteinsOuyang, Y bLane, WSMoore, K LProc. Natl. Acad. Sci. U.S.A. 95:2896-90123481380Pubmed2013Crystal structure of human tyrosylprotein sulfotransferase-2 reveals the mechanism of protein tyrosine sulfation reactionTeramoto, TakamasaFujikawa, YukariKawaguchi, YoshirouKurogi, KatsuhisaSoejima, MasayukiAdachi, RumiNakanishi, YuichiMishiro-Sato, EmiLiu, MCSakakibara, YSuiko, MKimura, MakotoKakuta, YoshimitsuNat Commun 4:1572LEFT-TO-RIGHT3.1.3.7IMPAD1 hydrolyses PAP to AMPThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>H2OwaterReactome DB_ID: 2022884Reactome Database ID Release 722022884Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2022884ReactomeR-ALL-20228843Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-2022884.3Piphosphate(3-)Reactome DB_ID: 8851226Reactome Database ID Release 728851226Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=8851226ReactomeR-ALL-88512264Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-8851226.4AMPadenosine 5'-monophosphateAdenylic acidAdenylate5'-AMP5'-Adenylic acid5'-Adenosine monophosphateAdenosine 5'-phosphateReactome DB_ID: 8953493Reactome Database ID Release 728953493Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=8953493ReactomeR-ALL-89534933Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-8953493.3ACTIVATIONIMPAD1:Mg2+Reactome DB_ID: 9992646IMPAD1IMPAD1E2RMJ7Reactome DB_ID: 9992644UniProt:E2RMJ7IMPAD1UniProtE2RMJ71EQUAL359EQUALReactome Database ID Release 729992644Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9992644ReactomeR-CFA-89534871Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-8953487.11Mg2+Magnesiummagnesium(2+)Mg++Reactome DB_ID: 5336432magnesium(2+) [ChEBI:18420]magnesium(2+)ChEBICHEBI:18420Reactome Database ID Release 725336432Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5336432ReactomeR-ALL-53364323Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-5336432.31Reactome Database ID Release 729992646Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9992646ReactomeR-CFA-89534911Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-8953491.1Reactome Database ID Release 729992647Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9992647Reactome Database ID Release 729992649Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9992649ReactomeR-CFA-89534991Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-8953499.1Sulfur is an essential element in all lifeforms used in the synthesis of sulfur-containing amino acids, maintenance of cellular redox states and detoxifying toxic compounds. 3'-phosphoadenosine 5'-phosphosulfate (PAPS) is the active form of sulfur used in these reactions, which consume PAPS, producing 3'-phosphoadenosine 5'-phosphate (PAP). PAP is degraded to 5′-AMP (AMP) by 3′-nucleotidase family. Mammals encode two 3′-nucleotidases, the Golgi-resident inositol monophosphatase 3 (IMPAD3 aka PAP phosphatase, gPAPP) and the cytosolic bisphosphate 3′-nucleotidase 1 (BPNT1, described in its own reaction). Both require Mg2+ as cofactor and both are inhibited by lithium (Hudson et al. 2013).23479625Pubmed2013Role for cytoplasmic nucleotide hydrolysis in hepatic function and protein synthesisHudson, Benjamin HFrederick, Joshua PDrake, Li YinMegosh, Louis CIrving, Ryan PYork, JDProc. Natl. Acad. Sci. U.S.A. 110:5040-5INHIBITIONReactome Database ID Release 728953507Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=8953507ReactomeR-HSA-89535071Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-8953507.1Li+Lithium ionlithium(1+)Reactome DB_ID: 8953505lithium(1+) [ChEBI:49713]lithium(1+)lithium cationLITHIUM IONLi(+)Lithium, ion (Li1+)lithium, ionChEBICHEBI:49713Reactome Database ID Release 728953505Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=8953505ReactomeR-ALL-89535053Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-8953505.3Reactome Database ID Release 729997321Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9997321ReactomeR-CFA-1565841Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-156584.1Two groups of sulfotransferease (SULT) enzymes catalyze the transfer of a sulfate group from 3-phosphoadenosine 5-phosphosulfate (PAPS) to a hydroxyl group on an acceptor molecule, yielding a sulfonated acceptor and 3-phosphoadenosine 5-phosphate (PAP). One is localized to the Golgi apparatus and mediates the sulfonation of proteoglycans. The second, annotated here, is cytosolic and mediates the sulfonation of a diverse array of small molecules, increasing their solubilities in water and modifying their physiological functions. There are probably thirteen or more human cytosolic SULT enzymes; eleven of these have been purified and characterized enzymatically, and are annotated here (Blanchard et al. 2004; Gamage et al. 2005). These enzymes appear to be active as dimers. Their substrate specificities are typically broad, and not related in an obvious way to their structures; indeed, apparently orthologous human and rodent SULT enzymes can have different substrate specificities (Glatt 2000), and none has been exhaustively characterized. The substrates listed in the table and annotated here are a sample of the known ones, chosen to indicate the range of activity of these enzymes and to capture some of their known physiologically important targets. Absence of a small molecule - enzyme pair from the table, however, may only mean that it has not yet been studied.16322073Pubmed2006Human Sulfotransferases and Their Role in Chemical MetabolismGamage, NBarnett, AHempel, NDuggleby, RGWindmill, KFMartin, JLMcManus, METoxicol Sci 90:5-2215167709Pubmed2004A proposed nomenclature system for the cytosolic sulfotransferase (SULT) superfamilyBlanchard, RLFreimuth, RRBuck, JWeinshilboum, RMCoughtrie, MWPharmacogenetics 14:199-211MethylationThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>LEFT-TO-RIGHT2.5.1.6MAT1A multimers transfer Ado from ATP to L-MetSAM is sythesized from methionine's reaction with ATPThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>L-MetL-methionineL-methionine zwitterionReactome DB_ID: 174390L-methionine zwitterion [ChEBI:57844]L-methionine zwitterionC5H11NO2S(2S)-2-azaniumyl-4-(methylsulfanyl)butanoateFFEARJCKVFRZRR-BYPYZUCNSA-NL-methionine(2S)-2-ammonio-4-(methylsulfanyl)butanoate149.21100CSCC[C@H]([NH3+])C([O-])=OInChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1ChEBICHEBI:57844Reactome Database ID Release 72174390Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=174390ReactomeR-ALL-1743904Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-174390.4SAMAdoMetS-adenosylmethionineS-adenosyl-L-methionineReactome DB_ID: 71284S-adenosyl-L-methionine [ChEBI:15414]S-adenosyl-L-methionineChEBICHEBI:15414Reactome Database ID Release 7271284Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=71284ReactomeR-ALL-712844Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-71284.4ACTIVATIONConverted from EntitySet in ReactomeMAT1A multimersReactome DB_ID: 9914042MAT1A:K+:2Mg2+ tetramerReactome DB_ID: 9914038MAT1A:K+:2Mg2+Reactome DB_ID: 9914036Mg2+Magnesiummagnesium(2+)Mg++Reactome DB_ID: 29926Reactome Database ID Release 7229926Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29926ReactomeR-ALL-299265Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29926.52MAT1AMAT1AE2R557Reactome DB_ID: 9914034UniProt:E2R557MAT1AUniProtE2R5571EQUAL395EQUALReactome Database ID Release 729914034Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914034ReactomeR-CFA-1743791Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-174379.11K+Potassiumpotassium(1+)Reactome DB_ID: 29804potassium(1+) [ChEBI:29103]potassium(1+)PotassiumK+ChEBICHEBI:29103Reactome Database ID Release 7229804Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29804ReactomeR-ALL-298043Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29804.31Reactome Database ID Release 729914036Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914036ReactomeR-CFA-1744021Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-174402.14Reactome Database ID Release 729914038Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914038ReactomeR-CFA-1744051Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-174405.1MAT1A:K+:2Mg2+ dimerReactome DB_ID: 99140402Reactome Database ID Release 729914040Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914040ReactomeR-CFA-1743951Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-174395.1Reactome Database ID Release 729914042Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914042ReactomeR-CFA-1743831Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-174383.1GENE ONTOLOGYGO:0004478Reactome Database ID Release 729914043Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914043Reactome Database ID Release 729914045Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914045ReactomeR-CFA-1743911Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-174391.1S-adenosylmethionine (AdoMet, SAM) is an essential metabolite in all cells. AdoMet is a precursor in the synthesis of polyamines. Methionine adenosyltransferases (MAT) catalyse the only known AdoMet biosynthetic reaction from methionine (L-Met) and ATP. In mammalian tissues, three different forms of MAT (MAT I, MAT III and MAT II) have been identified that are the product of two different genes (MAT1A and MAT2A). MAT1A binds 1 K+ and 2 Mg2+ (or Co2+, not shown here) in tetrameric or dimeric form (Corrales et al. 2002, Mato et al. 1997).9175157Pubmed1997S-adenosylmethionine synthesis: molecular mechanisms and clinical implicationsMato, JMAlvarez, LOrtiz, PPajares, MAPharmacol Ther 73:265-8012163696Pubmed2002Regulation of mammalian liver methionine adenosyltransferaseCorrales, FJPérez-Mato, ISánchez Del Pino, MMRuiz, FCastro, CGarcía-Trevijano, ERLatasa, UMartinez-Chantar, MLMartinez-Cruz, AAvila, MAMato, JMJ Nutr 132:2377S-2381SLEFT-TO-RIGHT2.5.1.6MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-MetAdoMet is sythesized from methionine's reaction with ATPThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>ACTIVATIONMAT2B:MAT2A:K+:2Mg2+Reactome DB_ID: 9967319MAT2A:K+:2Mg2+Reactome DB_ID: 996731721MAT2AMAT2AE2R431Reactome DB_ID: 9967315UniProt:E2R431MAT2AUniProtE2R4311EQUAL395EQUALReactome Database ID Release 729967315Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9967315ReactomeR-CFA-1743631Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-174363.11Reactome Database ID Release 729967317Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9967317ReactomeR-CFA-1743711Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-174371.11MAT2BMAT2BE2RT47Reactome DB_ID: 9967311UniProt:E2RT47MAT2BUniProtE2RT472EQUAL334EQUALReactome Database ID Release 729967311Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9967311ReactomeR-CFA-3512141Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-351214.11Reactome Database ID Release 729967319Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9967319ReactomeR-CFA-3535761Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-353576.1Reactome Database ID Release 729967320Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9967320Reactome Database ID Release 729967322Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9967322ReactomeR-CFA-56031141Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-5603114.1S-adenosylmethionine (AdoMet, SAM) is an essential metabolite in all cells. AdoMet is a precursor in the synthesis of polyamines. Methionine adenosyltransferases (MAT) catalyse the only known AdoMet biosynthetic reaction from methionine (L-Met) and ATP. In mammalian tissues, three different forms of MAT (MAT I, MAT III and MAT II) have been identified that are the product of two different genes (MAT1A and MAT2A). A third gene, MAT2B has been identified and its protein product is known to associate as a regulatory subunit with catalytic MAT2A (LeGros et al. 2000, Halim et al. 1999).10514445Pubmed1999Expression and functional interaction of the catalytic and regulatory subunits of human methionine adenosyltransferase in mammalian cellsHalim, A BLeGros, LGeller, AKotb, MJ. Biol. Chem. 274:29720-510644686Pubmed2000Cloning, expression, and functional characterization of the beta regulatory subunit of human methionine adenosyltransferase (MAT II)LeGros, H LHalim, A BGeller, A MKotb, MJ. Biol. Chem. 275:2359-66LEFT-TO-RIGHT2.1.1.676-mercaptopurine can be S-methylatedTPMT transfers CH3 from AdoMet to 6MPThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>6MP6-Mercaptopurinepurine-6-thiolReactome DB_ID: 158619purine-6-thiol [ChEBI:2208]purine-6-thiolChEBICHEBI:2208Reactome Database ID Release 72158619Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=158619ReactomeR-ALL-1586193Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-158619.3SAHAdoHcyS-adenosylhomocysteineS-adenosyl-L-homocysteineReactome DB_ID: 71285S-adenosyl-L-homocysteine [ChEBI:16680]S-adenosyl-L-homocysteineChEBICHEBI:16680Reactome Database ID Release 7271285Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=71285ReactomeR-ALL-712854Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-71285.46MMP6-Methylmercaptopurine6-methylthiopurineReactome DB_ID: 1586116-methylthiopurine [ChEBI:28279]6-methylthiopurineChEBICHEBI:28279Reactome Database ID Release 72158611Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=158611ReactomeR-ALL-1586113Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-158611.3ACTIVATIONTPMTTPMTQ8HX86Reactome DB_ID: 9910749UniProt:Q8HX86TPMTUniProtQ8HX861EQUAL245EQUALReactome Database ID Release 729910749Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9910749ReactomeR-CFA-1586281Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-158628.1GENE ONTOLOGYGO:0008119Reactome Database ID Release 729910750Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9910750Reactome Database ID Release 729910752Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9910752ReactomeR-CFA-1586091Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-158609.1Methylation is the major biotransformation route of thiopurine drugs such as 6-mercaptopurine (6MP), used in the treatment of inflammatory diseases such as rheumatoid arthritis and childhood acute lymphoblastic leukemia. 6MP and its thioguanine nucleotide metabolites are principally inactivated by thiopurine methyltransferase (TPMT)-catalysed S-methylation.<br><br>Defects in TPMT can cause thiopurine S methyltransferase deficiency (TPMT deficiency; MIM:610460). Patients with intermediate or no TPMT activity are at risk of toxicity such as myelosuppression after receiving standard doses of thiopurine drugs. Inter individual differences in response to these drugs are largely determined by genetic variation at the TPMT locus. TPMT exhibits an autosomal co dominant phenotype: About one in 300 people in Caucasian, African, African-American, and Asian populations are TPMT deficient. Approximately 6-10% of people in these populations inherit intermediate TPMT activity and are heterozygous at the TPMT locus. The rest are homozygous for the wild type allele and have high levels of TPMT activity. (Remy 1963, Weinshilboum et al. 1999, Couldhard & Hogarth 2005, Al Hadithy et al. 2005, Azimi et al. 2014).24734162Pubmed2014Assessment of Thiopurine-based drugs according to Thiopurine S-methyltransferase genotype in patients with Acute Lymphoblastic LeukemiaAzimi, FJafariyan, MKhatami, SMortazavi, YAzad, MIran J Ped Hematol Oncol 4:32-815788214Pubmed2005Thiopurines in inflammatory bowel disease: pharmacogenetics, therapeutic drug monitoring and clinical recommendationsAl Hadithy, AFde Boer, NKDerijks, LJEscher, JCMulder, CJBrouwers, JRDig Liver Dis 37:282-9713981612Pubmed1963Metabolism of thiopyrimidines and thiopurines. S-Methylation with S-adenosylmethionine transmethylase and catabolism in mammalian tissues.Remy, CNJ Biol Chem 238:1078-8410331075Pubmed1999Methylation pharmacogenetics: catechol O-methyltransferase, thiopurine methyltransferase, and histamine N-methyltransferaseWeinshilboum, RMOtterness, DMSzumlanski, CLAnnu Rev Pharmacol Toxicol 39:19-5216267626Pubmed2005The thiopurines: an updateCoulthard, SHogarth, LInvest New Drugs 23:523-32LEFT-TO-RIGHT2.1.1.87Pyridine can be N-methylatedNNMT transfers CH3 from AdoMet to PYThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>PYAzabenzenepyridineReactome DB_ID: 175973pyridine [ChEBI:16227]pyridineChEBICHEBI:16227Reactome Database ID Release 72175973Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=175973ReactomeR-ALL-1759733Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-175973.3MP+N-methylpyridinium ionN-methylpyridiniumReactome DB_ID: 175979N-methylpyridinium [ChEBI:15761]N-methylpyridiniumChEBICHEBI:15761Reactome Database ID Release 72175979Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=175979ReactomeR-ALL-1759793Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-175979.3ACTIVATIONNNMTNNMTJ9P673Reactome DB_ID: 9914331UniProt:J9P673NNMTUniProtJ9P6731EQUAL264EQUALReactome Database ID Release 729914331Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914331ReactomeR-CFA-1593591Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-159359.1GENE ONTOLOGYGO:0030760Reactome Database ID Release 729914332Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914332Reactome Database ID Release 729914334Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914334ReactomeR-CFA-1759871Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-175987.1Pyridine is a typical substrate for Nicotinamide N-methyltransferase (Van Haren et al. 2016).27570878Pubmed2016A Rapid and Efficient Assay for the Characterization of Substrates and Inhibitors of Nicotinamide N-Methyltransferasevan Haren, Matthijs JSastre Toraño, JavierSartini, DavideEmanuelli, MParsons, Richard BMartin, Nathaniel IBiochemistry 55:5307-15LEFT-TO-RIGHT2.1.1.6COMT transfer CH3 from AdoMet to 3,4DHBNZ3,4-dihydroxybenzoate can be O-methylatedThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>3,4DHBNZ3,4-dihydroxybenzoate3,4-dihydroxybenzoic acidprotocatechuateReactome DB_ID: 1759773,4-dihydroxybenzoic acid [ChEBI:36062]3,4-dihydroxybenzoic acidChEBICHEBI:36062Reactome Database ID Release 72175977Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=175977ReactomeR-ALL-1759773Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-175977.33H,4MBNZ3-hydroxy 4-methoxybenzoate3-hydroxy-4-methoxybenzoateReactome DB_ID: 1759783-hydroxy-4-methoxybenzoate [ChEBI:63797]3-hydroxy-4-methoxybenzoateisovanillateChEBICHEBI:63797Reactome Database ID Release 72175978Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=175978ReactomeR-ALL-1759783Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-175978.3ACTIVATIONCOMTCOMTF1P8Z9Reactome DB_ID: 9914324UniProt:F1P8Z9COMTUniProtF1P8Z91EQUAL271EQUALReactome Database ID Release 729914324Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914324ReactomeR-CFA-1759741Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-175974.1GENE ONTOLOGYGO:0016206Reactome Database ID Release 729914325Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914325Reactome Database ID Release 729914327Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914327ReactomeR-CFA-1759831Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-175983.1Dihydroxybenzoate is a typical substrate for Catechol O-methyltransferase8968737Pubmed1996Human methionine synthase: cDNA cloning and identification of mutations in patients of the cblG complementation group of folate/cobalamin disordersLeclerc, DCampeau, EGoyette, PAdjalla, CEChristensen, BRoss, MEydoux, PRosenblatt, DSRozen, RGravel, RAHum Mol Genet 5:1867-74LEFT-TO-RIGHT3.3.1.1S-adenoylhomocysteine is hydrolyzedAHCY:NAD+ tetramer hydrolyses AdoHcyThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>HCYShomocysteineReactome DB_ID: 174369homocysteine [ChEBI:17230]homocysteineChEBICHEBI:17230Reactome Database ID Release 72174369Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=174369ReactomeR-ALL-1743693Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-174369.3Ade-RibADENOCARD (TN)adenosineReactome DB_ID: 83909adenosine [ChEBI:16335]adenosineChEBICHEBI:16335Reactome Database ID Release 7283909Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=83909ReactomeR-ALL-839093Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-83909.3ACTIVATIONAHCY:NAD+ tetramerReactome DB_ID: 9914065AHCY:NAD+Reactome DB_ID: 99140631AHCYAHCYE2QXS7Reactome DB_ID: 9914061UniProt:E2QXS7AHCYUniProtE2QXS72EQUAL432EQUALReactome Database ID Release 729914061Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914061ReactomeR-CFA-1743731Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-174373.11Reactome Database ID Release 729914063Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914063ReactomeR-CFA-1743571Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-174357.14Reactome Database ID Release 729914065Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914065ReactomeR-CFA-1743581Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-174358.1GENE ONTOLOGYGO:0004013Reactome Database ID Release 729914066Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914066Reactome Database ID Release 729914068Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914068ReactomeR-CFA-1744011Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-174401.1Adenosylhomocysteinase (AHCY) is a tetrameric, NAD+-bound, cytosolic protein that regulates all adenosylmethionine-(AdoMet) dependent transmethylations by hydrolysing the feedback inhibitor adenosylhomocysteine (AdoHcy) to homocysteine (HCYS) and adenosine (Ade-Rib) (Turner et al. 1998, Yang et al. 2003).12590576Pubmed2003Catalytic strategy of S-adenosyl-L-homocysteine hydrolase: transition-state stabilization and the avoidance of abortive reactionsYang, XiaodaHu, YongboYin, Daniel HTurner, MAWang, MengmengBorchardt, Ronald THowell, PLKuczera, KrzysztofSchowen, Richard LBiochemistry 42:1900-99586999Pubmed1998Structure determination of selenomethionyl S-adenosylhomocysteine hydrolase using data at a single wavelengthTurner, M AYuan, C SBorchardt, R THershfield, M SSmith, G DHowell, P LNat. Struct. Biol. 5:369-76LEFT-TO-RIGHT2.1.1.13Methionine is reformedMTR transfers CH3 from MeCbl to HCYSThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>MTRR:MTR(MeCbl)Reactome DB_ID: 9914010MTRR:FMN:FADReactome DB_ID: 9914002MTRRMTRRF1PBT9Reactome DB_ID: 9914000UniProt:F1PBT9MTRRUniProtF1PBT91EQUAL725EQUALReactome Database ID Release 729914000Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914000ReactomeR-CFA-29809871Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2980987.11FMNFlavin mononucleotideRiboflavin-5-phosphateReactome DB_ID: 73524FMN [ChEBI:17621]FMNRiboflavin-5-phosphateFlavin mononucleotideChEBICHEBI:17621Reactome Database ID Release 7273524Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=73524ReactomeR-ALL-735242Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-73524.21FADFlavin adenine dinucleotideReactome DB_ID: 29386FAD [ChEBI:16238]FADFlavin adenine dinucleotideChEBICHEBI:16238Reactome Database ID Release 7229386Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29386ReactomeR-ALL-293862Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29386.21Reactome Database ID Release 729914002Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914002ReactomeR-CFA-31495301Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-3149530.11MTR:Zn2+:MeCblReactome DB_ID: 9914008Zn2+Zn++zinc(2+)Zinc ionZn(II)Reactome DB_ID: 29426zinc(2+) [ChEBI:29105]zinc(2+)ChEBICHEBI:29105Reactome Database ID Release 7229426Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29426ReactomeR-ALL-294263Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29426.31MeCblmethylcobalaminReactome DB_ID: 3149508methylcobalamin [ChEBI:28115]methylcobalaminMeCblmecobalaminCO-METHYLCOBALAMINChEBICHEBI:28115Reactome Database ID Release 723149508Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3149508ReactomeR-ALL-31495083Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-3149508.31MTRMTRE2R716Reactome DB_ID: 9914006UniProt:E2R716MTRUniProtE2R7161EQUAL1265EQUALReactome Database ID Release 729914006Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914006ReactomeR-CFA-1743761Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-174376.11Reactome Database ID Release 729914008Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914008ReactomeR-CFA-31495061Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-3149506.11Reactome Database ID Release 729914010Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914010ReactomeR-CFA-31495511Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-3149551.1MTRR:MTR(cob(I)alamin)Reactome DB_ID: 99140141MTR:Zn2+:cob(I)alaminReactome DB_ID: 99140121B12scob(I)alaminvitamin B12sReactome DB_ID: 3149496cob(I)alamin [ChEBI:15982]cob(I)alaminChEBICHEBI:15982Reactome Database ID Release 723149496Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3149496ReactomeR-ALL-31494962Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-3149496.211Reactome Database ID Release 729914012Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914012ReactomeR-CFA-31494971Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-3149497.11Reactome Database ID Release 729914014Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914014ReactomeR-CFA-31495161Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-3149516.1ACTIVATIONGENE ONTOLOGYGO:0008705Reactome Database ID Release 729914015Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914015Reactome Database ID Release 729914017Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914017ReactomeR-CFA-1743741Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-174374.1A methyl group from 5-methyltetrahydrofolate is transferred to homocysteine (HCYS) via a meCbl intermediate, forming methionine (L-Met) (Leclerc et al. 1996).LEFT-TO-RIGHT1.20.4.2GSTO1 dimer reduces methylarsonate to methylarsoniteThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>GSHReduced glutathioneglutathione5-L-Glutamyl-L-cysteinylglycineN-(N-gamma-L-Glutamyl-L-cysteinyl)glycinegamma-L-Glutamyl-L-cysteinyl-glycineReactome DB_ID: 29450glutathione [ChEBI:16856]glutathioneChEBICHEBI:16856Reactome Database ID Release 7229450Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29450ReactomeR-ALL-294503Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29450.32methylarsonatemethylarsonate(2-)Reactome DB_ID: 5696214methylarsonate(2-) [ChEBI:16005]methylarsonate(2-)MeAsO3(2-)[As(CH3)O3](2-)ChEBICHEBI:16005Reactome Database ID Release 725696214Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5696214ReactomeR-ALL-56962143Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-5696214.3methylarsoniteReactome DB_ID: 5696224methylarsonite [ChEBI:14597]methylarsonite[As(CH3)O2](2-)ChEBICHEBI:14597Reactome Database ID Release 725696224Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5696224ReactomeR-ALL-56962242Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-5696224.2GSSGoxidized glutathioneglutathione disulfideReactome DB_ID: 111745glutathione disulfide [ChEBI:17858]glutathione disulfideChEBICHEBI:17858Reactome Database ID Release 72111745Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=111745ReactomeR-ALL-1117453Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-111745.3ACTIVATIONGSTO1 dimerReactome DB_ID: 9914368GSTO1GSTO1F1PUM3Reactome DB_ID: 9914366UniProt:F1PUM3GSTO1UniProtF1PUM31EQUAL241EQUALReactome Database ID Release 729914366Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914366ReactomeR-CFA-1760431Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-176043.12Reactome Database ID Release 729914368Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914368ReactomeR-CFA-1988251Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-198825.1GENE ONTOLOGYGO:0050610Reactome Database ID Release 729975937Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9975937Reactome Database ID Release 729975939Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9975939ReactomeR-CFA-56962301Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-5696230.1Glutathione S-transferase omega-1 (GSTO1 aka monomethylarsonic acid reductase, MMA(V) reductase) is a bifunctional enzyme that has glutathione S-transferase activity and also takes part in the biotransformation of inorganic arsenic. It mediates the reduction of methylarsonate to methylarsonite (Zakharyan et al. 2001).11511179Pubmed2001Human monomethylarsonic acid (MMA(V)) reductase is a member of the glutathione-S-transferase superfamilyZakharyan, R ASampayo-Reyes, AHealy, S MTsaprailis, GBoard, P GLiebler, D CAposhian, H VChem. Res. Toxicol. 14:1051-7LEFT-TO-RIGHT2.1.1N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIIIThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>MMAIIImonomethylarsonous acidmethylarsonous acidReactome DB_ID: 6806829methylarsonous acid [ChEBI:17826]methylarsonous acidChEBICHEBI:17826Reactome Database ID Release 726806829Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6806829ReactomeR-ALL-68068293Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-6806829.3DMAAdimethylarsonic aciddimethylarsinic acidReactome DB_ID: 6800127dimethylarsinic acid [ChEBI:48765]dimethylarsinic acidDimethylarsinate[As(CH3)2O(OH)]Me2As(=O)OHCACODYLIC ACIDKakodylsaeureChEBICHEBI:48765Reactome Database ID Release 726800127Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6800127ReactomeR-ALL-68001273Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-6800127.3ACTIVATIONN6AMT1:TRMT112Reactome DB_ID: 9981346E2RGM1TRMT112TRMT112Reactome DB_ID: 9981344UniProt:E2RGM1TRMT112UniProtE2RGM11EQUAL125EQUALReactome Database ID Release 729981344Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9981344ReactomeR-CFA-67865451Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-6786545.11N6AMT1J9P1B3Reactome DB_ID: 9981340UniProt:J9P1B3UniProtJ9P1B31EQUAL214EQUALReactome Database ID Release 729981340Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9981340ReactomeR-CFA-11832041Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-1183204.11Reactome Database ID Release 729981346Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9981346ReactomeR-CFA-68001331Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-6800133.1GENE ONTOLOGYGO:0008168Reactome Database ID Release 729981350Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9981350Reactome Database ID Release 729981352Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9981352ReactomeR-CFA-68001491Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-6800149.1Inorganic arsenic (iAs) compounds are human carcinogens. The most toxic arsenic metabolite is monomethylarsonous acid (MMAIII). Arsenic (3+) methyltransferase (AS3MT) is the primary enzyme responsible for methylating MMAIII to the less toxic dimethylarsonic acid (DMAA). A human ortholog of yeast MTQ2, HemK methyltransferase family member 2 (aka N(6)-adenine-specific DNA methyltransferase 1, N6AMT1), is also able to methylate MMAIII using S-adenosyl L-methionine as methyl donor (Ren et al. 2011). N6AMT1 forms a heterodimer with multifunctional methyltransferase subunit TRM112-like protein (TRMT112) (Figaro et al. 2008).18539146Pubmed2008HemK2 protein, encoded on human chromosome 21, methylates translation termination factor eRF1Figaro, SabineScrima, NathalieBuckingham, Richard HHeurgué-Hamard, ValérieFEBS Lett. 582:2352-621193388Pubmed2011Involvement of N-6 adenine-specific DNA methyltransferase 1 (N6AMT1) in arsenic biomethylation and its role in arsenic-induced toxicityRen, XuefengAleshin, MariaJo, William JDills, RusselKalman, David AVulpe, Christopher DSmith, Martyn TZhang, LuopingEnviron. Health Perspect. 119:771-7Reactome Database ID Release 729997323Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9997323ReactomeR-CFA-1565811Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-156581.1GENE ONTOLOGYGO:0032259Methylation is a common but minor pathway of Phase II conjugation compared to glucuronidation or sulfonation. The cofactor used in methylation conjugation is S-adenosylmethionine (SAM). SAM is the second most widely used enzyme substrate after ATP and is involved in a wide range of important biological processes. SAM is sythesized from methionine's reaction with ATP, catalyzed by methionine adenosyltransferase (MAT). There are two genes, MAT1A and MAT2A, which encode for two homologous MAT catalytic subunits, 1 and 2.<br>During conjugation with nucleophilic substrates, the methyl group attached to the sulfonium ion of SAM is transferred to the substrate forming the conjugate. SAM, having lost the methyl moiety, is converted to S-adenosylhomocysteine (SAH). SAH can be hydrolyzed to form adenosine and homocysteine. Homocysteine can either be converted to glutathione or methylated to form methionine, thus forming the starting point for SAM synthesis and completing the cycle.<br>Fuctional groups attacked are phenols, catechols, aliphatic and aromatic amines and sulfhydryl-containing groups. The enzymes that catalyze the transfer of the methyl group to these functional groups are the methyltransferases (MT). MTs are small, cytosolic, monomeric enzymes that utilize SAM as a methyl donor. There are many MTs but the best studied ones are named on the basis of their prototypical substrates: <i><b>COMT</b> (catechol O-methyltransferase)</i>, <i><b>TPMT</b> (thiopurine methyltransferase)</i>, <i><b>TMT</b> (thiol methyltransferase)</i>, <i><b>HNMT</b> (histamine N-methyltransferase)</i> and <i><b>NNMT</b> (nicotinamide N-methyltransferase)</i>. An example of each enzyme mentioned is given. In each case, a typical substrate for the enzyme is shown.10898761Pubmed2000Changes in methionine adenosyltransferase and S-adenosylmethionine homeostasis in alcoholic rat liverLu, SCHuang, ZZYang, HMato, JMAvila, MATsukamoto, HAm J Physiol Gastrointest Liver Physiol 279:G178-8515130560Pubmed2004S-adenosylmethionine: nothing goes to wasteFontecave, MAtta, MMulliez, ETrends Biochem Sci 29:243-9Glutathione conjugationThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Glutathione synthesis and recyclingThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>LEFT-TO-RIGHT3.5.2.9OPLAH hydrolyses OPRO to L-GluCleavage of 5-oxoproline to form glutamateThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>2OPRO5-oxoproline5-oxo-L-prolineReactome DB_ID: 12479425-oxo-L-proline [ChEBI:18183]5-oxo-L-prolineChEBICHEBI:18183Reactome Database ID Release 721247942Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1247942ReactomeR-ALL-12479423Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-1247942.3L-GluL-GlutamateL-glutamate(1-)L-glutamic acidL-Glutaminic acidReactome DB_ID: 29404L-glutamate(1-) [ChEBI:29985]L-glutamate(1-)L-glutamic acid, ion(1-)[NH3+][C@@H](CCC([O-])=O)C([O-])=OWHUUTDBJXJRKMK-VKHMYHEASA-MC5H8NO4146.12136(2S)-2-ammoniopentanedioatehydrogen L-glutamateL-glutamateL-glutamic acid monoanionInChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1ChEBICHEBI:29985Reactome Database ID Release 7229404Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29404ReactomeR-ALL-294044Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29404.4ACTIVATIONOPLAHReactome DB_ID: 9943127OPLAHF1PGA9Reactome DB_ID: 9943125UniProt:F1PGA9UniProtF1PGA91EQUAL1288EQUALReactome Database ID Release 729943125Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9943125ReactomeR-CFA-12479481Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-1247948.12Reactome Database ID Release 729943127Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9943127ReactomeR-CFA-12479261Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-1247926.1GENE ONTOLOGYGO:0017168Reactome Database ID Release 729943128Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9943128Reactome Database ID Release 729943130Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9943130ReactomeR-CFA-12479351Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-1247935.15-oxoprolinase catalyzes the cleavage of 5-oxoproline to form L-glutamate, coupled to the hydrolysis of ATP to ADP and inorganic phosphate (Chen et al, 1998).9516961Pubmed1998Characterization of 5-oxo-L-prolinase in normal and tumor tissues of humans and rats: a potential new target for biochemical modulation of glutathioneChen, XSchecter, RLGriffith, OWHayward, MAAlpert, LCBatist, GClin Cancer Res 4:131-8LEFT-TO-RIGHT6.3.2.2GCL ligates L-Glu to L-CysGlutamate and cysteine combineThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>L-CysL-2-amino-3-mercaptopropionic acidL-cysteine zwitterionL-cysteineReactome DB_ID: 111707L-cysteine zwitterion [ChEBI:35235]L-cysteine zwitterionC3H7NO2S(2R)-2-ammonio-3-sulfanylpropanoate121.15922[NH3+][C@@H](CS)C([O-])=OL-cysteineInChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1(2R)-2-ammonio-3-mercaptopropanoateXUJNEKJLAYXESH-REOHCLBHSA-NChEBICHEBI:35235Reactome Database ID Release 72111707Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=111707ReactomeR-ALL-1117074Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-111707.4gGluCysgamma-glutamyl-L-cysteineL-gamma-glutamyl-L-cysteineReactome DB_ID: 174393L-gamma-glutamyl-L-cysteine [ChEBI:17515]L-gamma-glutamyl-L-cysteineChEBICHEBI:17515Reactome Database ID Release 72174393Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=174393ReactomeR-ALL-1743933Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-174393.3ACTIVATIONGCLReactome DB_ID: 9913984GCLMF1P7D3Reactome DB_ID: 9913982UniProt:F1P7D3UniProtF1P7D31EQUAL274EQUALReactome Database ID Release 729913982Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9913982ReactomeR-CFA-1743561Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-174356.11GCLCGCLCE2RPJ4Reactome DB_ID: 9913978UniProt:E2RPJ4GCLCUniProtE2RPJ41EQUAL637EQUALReactome Database ID Release 729913978Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9913978ReactomeR-CFA-1743851Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-174385.11Reactome Database ID Release 729913984Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9913984ReactomeR-CFA-1743771Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-174377.1GENE ONTOLOGYGO:0004357Reactome Database ID Release 729913985Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9913985Reactome Database ID Release 729913987Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9913987ReactomeR-CFA-1743671Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-174367.1The first step in the formation of glutathione is the ligation of glutamate with cysteine, catalysed by the dimeric protein glutamate-cysteine ligase, GCL (Gipp et al. 1995, Misra & Griffith 1998).7826375Pubmed1995Cloning and sequencing of the cDNA for the light subunit of human liver gamma-glutamylcysteine synthetase and relative mRNA levels for heavy and light subunits in human normal tissuesGipp, JJBailey, HHMulcahy, RTBiochem Biophys Res Commun 206:584-99675072Pubmed1998Expression and purification of human gamma-glutamylcysteine synthetaseMisra, IGriffith, OWProtein Expr Purif 13:268-76LEFT-TO-RIGHT4.3.2.9GGCT transforms gGluCys to OPROFormation of 5-oxoproline from gamma-glutamylcysteineThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>ACTIVATIONGGCT dimerReactome DB_ID: 9943118GGCTGGCTE2R9K5Reactome DB_ID: 9943116UniProt:E2R9K5GGCTUniProtE2R9K51EQUAL188EQUALReactome Database ID Release 729943116Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9943116ReactomeR-CFA-12479001Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-1247900.12Reactome Database ID Release 729943118Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9943118ReactomeR-CFA-12479051Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-1247905.1GENE ONTOLOGYGO:0003839Reactome Database ID Release 729943119Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9943119Reactome Database ID Release 729943121Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9943121ReactomeR-CFA-12479221Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-1247922.1Gamma-glutamylcyclotransferase (GGCT) homodimer (Bae et al. 2008) catalyses the formation of 5-oxoproline from gamma-glutamylcysteine (gGluCys), therby playing a role in glutathione homeostasis (Oakley et al. 2008).18515354Pubmed2008The identification and structural characterization of C7orf24 as gamma-glutamyl cyclotransferase. An essential enzyme in the gamma-glutamyl cycleOakley, AJYamada, TLiu, DCoggan, MClark, AGBoard, PGJ Biol Chem 283:22031-4217932939Pubmed2008Crystal structure of Homo sapiens protein LOC79017Bae, EBingman, CAAceti, DJPhillips GN, JrProteins 70:588-91LEFT-TO-RIGHT6.3.2.3GSS:Mg2+ dimer synthesizes GSHgamma-glutamylcysteine combines with glycine to form glutathioneThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>GlyL-glycineglycine zwitterionglycineAminoacetic acidReactome DB_ID: 29424glycine zwitterion [ChEBI:57305]glycine zwitterionglycineDHMQDGOQFOQNFH-UHFFFAOYSA-N2-azaniumylacetateC2H5NO2InChI=1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5)[NH3+]CC([O-])=O75.06660ChEBICHEBI:57305Reactome Database ID Release 7229424Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29424ReactomeR-ALL-294244Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29424.4ACTIVATIONGSS:Mg2+ dimerReactome DB_ID: 99140542GSSGSSF1Q2D2Reactome DB_ID: 9914052UniProt:F1Q2D2GSSUniProtF1Q2D22EQUAL474EQUALReactome Database ID Release 729914052Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914052ReactomeR-CFA-1743641Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-174364.12Reactome Database ID Release 729914054Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914054ReactomeR-CFA-1743821Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-174382.1GENE ONTOLOGYGO:0004363Reactome Database ID Release 729914055Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914055Reactome Database ID Release 729914057Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914057ReactomeR-CFA-1743941Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-174394.1In the second step in the formation of glutathione, gamma-glutamylcysteine (gGluCys) ligates with glycine (Gly) to form glutathione (GSH) (Gali & Board 1995). This reaction is catalysed by glutathione synthetase (GSS), a homodimeric enzyme present in the cytosol which requires one Mg2+ cofactor per subunit for activity (Polekhina et al. 1999).7646467Pubmed1995Sequencing and expression of a cDNA for human glutathione synthetaseGali, RRBoard, PGBiochem J 310:353-810369661Pubmed1999Molecular basis of glutathione synthetase deficiency and a rare gene permutation eventPolekhina, GBoard, P GGali, R RRossjohn, JParker, M WEMBO J. 18:3204-13INHIBITIONGSH acts as a feedback inhibitor of the cycle because it can competitively inhibit gGCS (Ristoff and Larsson, 1998).Reactome Database ID Release 721260991Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1260991ReactomeR-HSA-12609911Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1260991.19679548Pubmed1998Patients with genetic defects in the gamma-glutamyl cycleRistoff, ELarsson, AChem Biol Interact 111:113-21LEFT-TO-RIGHT3.4.19.13GGT dimers hydrolyse GSHThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>GSHReduced glutathioneglutathione5-L-Glutamyl-L-cysteinylglycineN-(N-gamma-L-Glutamyl-L-cysteinyl)glycinegamma-L-Glutamyl-L-cysteinyl-glycineReactome DB_ID: 1247892Reactome Database ID Release 721247892Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1247892ReactomeR-ALL-12478923Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-1247892.3H2OwaterReactome DB_ID: 109276Reactome Database ID Release 72109276Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=109276ReactomeR-ALL-1092764Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-109276.4CysGlycysteinylglycineL-cysteinylglycinecysteine-glycineReactome DB_ID: 1247934L-cysteinylglycine [ChEBI:4047]L-cysteinylglycineChEBICHEBI:4047Reactome Database ID Release 721247934Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1247934ReactomeR-ALL-12479343Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-1247934.3L-GluL-GlutamateL-glutamate(1-)L-glutamic acidL-Glutaminic acidReactome DB_ID: 210382Reactome Database ID Release 72210382Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=210382ReactomeR-ALL-2103824Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-210382.4ACTIVATIONConverted from EntitySet in ReactomeGGT dimersgamma-glutamyltransferasesReactome DB_ID: 9967037GGT1 dimerReactome DB_ID: 9922574GGT1GGT1(381-569)E2RTH3Reactome DB_ID: 9922572UniProt:E2RTH3GGT1UniProtE2RTH3381EQUAL569EQUALReactome Database ID Release 729922572Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9922572ReactomeR-CFA-89432631Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-8943263.11GGT1GGT1(1-380)E2RTH3Reactome DB_ID: 99225701EQUAL380EQUALReactome Database ID Release 729922570Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9922570ReactomeR-CFA-12478891Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-1247889.11Reactome Database ID Release 729922574Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9922574ReactomeR-CFA-12478981Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-1247898.1GGT5 dimerReactome DB_ID: 9922582J9P2C6GGT5(388-586)Reactome DB_ID: 9922580UniProt:J9P2C6UniProtJ9P2C6388EQUAL586EQUALReactome Database ID Release 729922580Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9922580ReactomeR-CFA-2653121Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-265312.11J9P2C6GGT5(1-387)Reactome DB_ID: 99225781EQUAL387EQUALReactome Database ID Release 729922578Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9922578ReactomeR-CFA-2653131Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-265313.11Reactome Database ID Release 729922582Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9922582ReactomeR-CFA-2653141Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-265314.1GGT6 dimerReactome DB_ID: 9967023GGT6GGT6(?-493)E2RKU6Reactome DB_ID: 9967021UniProt:E2RKU6GGT6UniProtE2RKU61EQUAL493EQUALReactome Database ID Release 729967021Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9967021ReactomeR-CFA-12479361Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-1247936.11GGT6E2RKU6Reactome DB_ID: 9967019Reactome Database ID Release 729967019Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9967019ReactomeR-CFA-12479441Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-1247944.11Reactome Database ID Release 729967023Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9967023ReactomeR-CFA-12479061Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-1247906.1GGT7 dimerReactome DB_ID: 9967031GSSGGT7(1-472)F6X876Reactome DB_ID: 9967027UniProt:F6X876GSSUniProtF6X8761EQUAL472EQUALReactome Database ID Release 729967027Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9967027ReactomeR-CFA-12478901Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-1247890.11GSSGGT7(473-662)F6X876Reactome DB_ID: 9967029473EQUAL662EQUALReactome Database ID Release 729967029Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9967029ReactomeR-CFA-12479191Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-1247919.11Reactome Database ID Release 729967031Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9967031ReactomeR-CFA-12479501Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-1247950.1GGT3P dimerReactome DB_ID: 9967035GGT1GGT3P(381-568)E2RTH3Reactome DB_ID: 9967033381EQUAL568EQUALReactome Database ID Release 729967033Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9967033ReactomeR-CFA-54902601Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-5490260.111Reactome Database ID Release 729967035Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9967035ReactomeR-CFA-54902441Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-5490244.1Reactome Database ID Release 729967037Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9967037ReactomeR-CFA-12479461Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-1247946.1GENE ONTOLOGYGO:0036374Reactome Database ID Release 729967038Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9967038Reactome Database ID Release 729991026Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9991026ReactomeR-CFA-89432791Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-8943279.1GGT (gamma-glutamyl transpeptidase) dimers associated with the plasma membrane (Hanigan & Frierson 1996) hydrolyze extracellular glutathione (GSH) to form cysteinylglycine (CysGly) and glutamate (L-Glu). GGT1 has been extensively characterized. The active dimeric form of the enzyme is generated by autohydrolysis (West et al. 2011) and in vitro can catalyze both the reaction of GSH with water annotated here, and the reaction of GSH with a free amino acid or dipeptide to generate a gamma-glutamyl-amino acid and cysteinylglycine (Castonguay et al. 2007; Pawlak et al. 1989; Tate & Ross 1977; Thompson & Meister 1976). Based on amino acid sequence similarity, Heisterkamp et al. (2008) identified five additional dimeric proteins, GGT2, 3P, 5, 6, and 7, likely to catalyze the same reactions. West et al. (2013), however, found that GGT2 had no catalytic activity in vitro.17924658Pubmed2007Kinetic characterization and identification of the acylation and glycosylation sites of recombinant human gamma-glutamyltranspeptidaseCastonguay, RoselyneHalim, DanyMorin, MylèneFurtos, AlexandraLherbet, ChristianBonneil, EricThibault, PierreKeillor, Jeffrey WBiochemistry 46:12253-6219463Pubmed1977Human kidney gamma-glutamyl transpeptidase. Catalytic properties, subunit structure, and localization of the gamma-glutamyl binding site on the light subunitTate, Suresh SRoss, M ElizabethJ Biol Chem 252:6042-59080Pubmed1976Hydrolysis and transfer reactions catalyzed by gamma-glutamyl transpeptidase; evidence for separate substrate sites and for high affinity of L-cystineThompson, Gregory AMeister, AltonBiochem. Biophys. Res. Commun. 71:32-62573352Pubmed1989Different gamma-glutamyl transpeptidase mRNAs are expressed in human liver and kidneyPawlak, AWu, SJBulle, FSuzuki, AChikhi, NFerry, NBaik, JHSiegrist, SGuellaën, GBiochem Biophys Res Commun 164:912-821712391Pubmed2011Autocatalytic cleavage of human gamma-glutamyl transpeptidase is highly dependent on N-glycosylation at asparagine 95West, Matthew BWickham, StephanieQuinalty, Leslie MPavlovicz, Ryan ELi, ChenglongHanigan, Marie HJ. Biol. Chem. 286:28876-8823682772Pubmed2013Human GGT2 does not autocleave into a functional enzyme: A cautionary tale for interpretation of microarray data on redox signalingWest, Matthew BWickham, StephanieParks, Eileen ESherry, David MHanigan, Marie HAntioxid. Redox Signal. 19:1877-888813074Pubmed1996Immunohistochemical detection of gamma-glutamyl transpeptidase in normal human tissueHanigan, Marie HFrierson, Henry FJ. Histochem. Cytochem. 44:1101-818357469Pubmed2008The human gamma-glutamyltransferase gene familyHeisterkamp, NGroffen, JWarburton, DSneddon, TPHum Genet 123:321-32LEFT-TO-RIGHTCNDP2:2Mn2+ dimer hydrolyses CysGlyThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>CysGlycysteinylglycineL-cysteinylglycinecysteine-glycineReactome DB_ID: 1247904Reactome Database ID Release 721247904Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1247904ReactomeR-ALL-12479043Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-1247904.3ACTIVATIONCNDP2:2Mn2+ dimerReactome DB_ID: 9943109Mn2+Manganesemanganese(2+)Mn(II)Reactome DB_ID: 29418manganese(2+) [ChEBI:29035]manganese(2+)Mn(2+)MANGANESE (II) IONmanganese, ion (Mn2+)manganese(II)manganous ionChEBICHEBI:29035Reactome Database ID Release 7229418Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29418ReactomeR-ALL-294183Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29418.34CNDP2CNDP2E2R134Reactome DB_ID: 9943107UniProt:E2R134CNDP2UniProtE2R1342EQUAL475EQUALReactome Database ID Release 729943107Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9943107ReactomeR-CFA-12584101Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-1258410.12Reactome Database ID Release 729943109Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9943109ReactomeR-CFA-12584211Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-1258421.1GENE ONTOLOGYGO:0004180Reactome Database ID Release 729943110Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9943110Reactome Database ID Release 729943112Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9943112ReactomeR-CFA-12479101Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-1247910.1Cytosolic, non-specific peptidase (CNDP2) can hydrolyse cysteinylglycine (CysGly) to release cysteine (L-Cys) and glycine (Gly) (Tuefel et al. 2003). CNDP2 is functional as a homodimer and requires 2 Mn2+ ion per subunit.12473676Pubmed2003Sequence identification and characterization of human carnosinase and a closely related non-specific dipeptidaseTeufel, MSaudek, VLedig, JPBernhardt, ABoularand, SCarreau, ACairns, NJCarter, CCowley, DJDuverger, DGanzhorn, AJGuenet, CHeintzelmann, BLaucher, VSauvage, CSmirnova, TJ Biol Chem 278:6521-31LEFT-TO-RIGHT4.3.2.9CHAC1,2 cleaves GSH to OPRO and CysGlyThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>ACTIVATIONConverted from EntitySet in ReactomeCHAC1,2Reactome DB_ID: 9977402CHAC1CHAC1E2R9S1Reactome DB_ID: 9977396UniProt:E2R9S1CHAC1UniProtE2R9S11EQUAL264EQUALReactome Database ID Release 729977396Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9977396ReactomeR-CFA-67859411Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-6785941.1CHAC2CHAC2E2R232Reactome DB_ID: 9977400UniProt:E2R232CHAC2UniProtE2R2321EQUAL184EQUALReactome Database ID Release 729977400Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9977400ReactomeR-CFA-67859271Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-6785927.1Reactome Database ID Release 729977402Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9977402ReactomeR-CFA-67859171Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-6785917.1Reactome Database ID Release 729977403Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9977403Reactome Database ID Release 729977405Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9977405ReactomeR-CFA-67859281Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-6785928.1Glutathione-specific gamma-glutamylcyclotransferases 1 and 2 (CHAC1 and 2) catalyse the specific cleavage of glutathione (GSH) into 5-oxoproline (OPRO) and a cysteinylglycine (CysGly) dipeptide. GSH acts a redox buffer in cells and its depletion is an important factor for apoptosis, oxidative stress and progression of cancer. CHAC1 and 2 act as proapototic agents with implications for human health and disease (Mungrue et al. 2009, Crawford et al. 2015).19109178Pubmed2009CHAC1/MGC4504 is a novel proapoptotic component of the unfolded protein response, downstream of the ATF4-ATF3-CHOP cascadeMungrue, Imran NPagnon, JoanneKohannim, OmidGargalovic, Peter SLusis, Aldons JJ. Immunol. 182:466-7625931127Pubmed2015Human CHAC1 Protein Degrades Glutathione, and mRNA Induction Is Regulated by the Transcription Factors ATF4 and ATF3 and a Bipartite ATF/CRE Regulatory ElementCrawford, Rebecca RPrescott, Eugenia TSylvester, Charity FHigdon, Ashlee NShan, JixiuKilberg, MSMungrue, Imran NJ. Biol. Chem. 290:15878-91Reactome Database ID Release 729997607Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9997607ReactomeR-CFA-1744031Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-174403.1GENE ONTOLOGYGO:0006750The combination of glutamate, cysteine and ATP is required to form glutathione. The steps involved in the synthesis and recycling of glutathione are outlined (Meister, 1988).3053703Pubmed1988Glutathione metabolism and its selective modificationMeister, AltonJ Biol Chem 263:17205-8LEFT-TO-RIGHT3.1.2.12ESD dimer hydrolyses S-FGSH to GSHThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>H2OwaterReactome DB_ID: 113519Reactome Database ID Release 72113519Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113519ReactomeR-ALL-1135193Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-113519.3S-FGSHS-formylglutathioneReactome DB_ID: 5693723S-formylglutathione [ChEBI:16225]S-formylglutathioneChEBICHEBI:16225Reactome Database ID Release 725693723Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5693723ReactomeR-ALL-56937233Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-5693723.3GSHReduced glutathioneglutathione5-L-Glutamyl-L-cysteinylglycineN-(N-gamma-L-Glutamyl-L-cysteinyl)glycinegamma-L-Glutamyl-L-cysteinyl-glycineReactome DB_ID: 158543Reactome Database ID Release 72158543Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=158543ReactomeR-ALL-1585433Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-158543.3formateformic acidReactome DB_ID: 194712formic acid [ChEBI:30751]formic acidChEBICHEBI:30751Reactome Database ID Release 72194712Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=194712ReactomeR-ALL-1947123Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-194712.3ACTIVATIONESD dimerReactome DB_ID: 9975250ESDESDE2RCQ9Reactome DB_ID: 9975248UniProt:E2RCQ9ESDUniProtE2RCQ92EQUAL282EQUALReactome Database ID Release 729975248Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9975248ReactomeR-CFA-56937181Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-5693718.12Reactome Database ID Release 729975250Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9975250ReactomeR-CFA-56937171Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-5693717.1GENE ONTOLOGYGO:0018738Reactome Database ID Release 729975251Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9975251Reactome Database ID Release 729975253Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9975253ReactomeR-CFA-56937241Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-5693724.1S-formylglutathione hydrolase (ESD, esterase D) is a homodimeric enzyme in the ER lumen of red blood cells that can hydrolyse S-formylglutathione (S-FGSH) to glutathione (GSH) and formate (Hopkinson et al. 1973, Eiberg & Mohr 1986). It is also able to hydrolyse 4-methylumbelliferyl acetate (not shown here).4768551Pubmed1973Esterase D: a new human polymorphismHopkinson, D AMestriner, M ACortner, JHarris, HAnn. Hum. Genet. 37:119-373770744Pubmed1986Identity of the polymorphisms for esterase D and S-formylglutathione hydrolase in red blood cellsEiberg, HMohr, JHum. Genet. 74:174-5LEFT-TO-RIGHT2.5.1.18MGST trimers conjugate GSH with luminal substratesGST trimers transfer GS from GSH to luminal substratesThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Converted from EntitySet in Reactomeelectrophilic substrateReactome DB_ID: 176065AFXBOAflatoxin B1 exo-8,9-oxideaflatoxin B1 exo-8,9-epoxideReactome DB_ID: 156523aflatoxin B1 exo-8,9-epoxide [ChEBI:30725]aflatoxin B1 exo-8,9-epoxideChEBICHEBI:30725Reactome Database ID Release 72156523Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=156523ReactomeR-ALL-1565233Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-156523.3EtOEthylene oxideoxiraneReactome DB_ID: 38987oxirane [ChEBI:27561]oxiraneChEBICHEBI:27561Reactome Database ID Release 7238987Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=38987ReactomeR-ALL-389873Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-38987.3NABQIN-AcetylbenzoquinoneimineN-acetyl-1,4-benzoquinone imineReactome DB_ID: 76396N-acetyl-1,4-benzoquinone imine [ChEBI:29132]N-acetyl-1,4-benzoquinone imineChEBICHEBI:29132Reactome Database ID Release 7276396Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=76396ReactomeR-ALL-763963Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-76396.3Reactome Database ID Release 72176065Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=176065ReactomeR-ALL-1760651Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-176065.1Converted from EntitySet in Reactomeelectrophilic substrate:SGReactome DB_ID: 176048Aflatoxin exo-8,9-oxide glutathione conjugate8,9-dihydro-8-(S-glutathionyl)-9-hydroxyaflatoxin B1Reactome DB_ID: 1592148,9-dihydro-8-(S-glutathionyl)-9-hydroxyaflatoxin B1 [ChEBI:2505]8,9-dihydro-8-(S-glutathionyl)-9-hydroxyaflatoxin B1ChEBICHEBI:2505Reactome Database ID Release 72159214Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=159214ReactomeR-ALL-1592143Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-159214.3S-(2-hydroxyethyl)glutathioneS-2-(hydroxyethyl)-glutathioneReactome DB_ID: 158541S-(2-hydroxyethyl)glutathione [ChEBI:35896]S-(2-hydroxyethyl)glutathioneS-2-(hydroxyethyl)-glutathioneChEBICHEBI:35896Reactome Database ID Release 72158541Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=158541ReactomeR-ALL-1585413Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-158541.3ACAP-GSHacetaminophen glutathione conjugateReactome DB_ID: 158549acetaminophen glutathione conjugate [ChEBI:32639]acetaminophen glutathione conjugate3-(Glutathion-S-yl)acetaminophenAA-GlutathionAA-GshAcetaminophen glutathionGlutathione-S-acetaminophen conjugateChEBICHEBI:32639Reactome Database ID Release 72158549Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=158549ReactomeR-ALL-1585493Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-158549.3Reactome Database ID Release 72176048Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=176048ReactomeR-ALL-1760481Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-176048.1ACTIVATIONConverted from EntitySet in ReactomeMGST trimersReactome DB_ID: 9914429MGST1 trimerReactome DB_ID: 9914415MGST1MGST1E2RHK1Reactome DB_ID: 9914413UniProt:E2RHK1MGST1UniProtE2RHK12EQUAL155EQUALReactome Database ID Release 729914413Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914413ReactomeR-CFA-1585451Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-158545.13Reactome Database ID Release 729914415Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914415ReactomeR-CFA-1585481Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-158548.1MGST2 trimerReactome DB_ID: 9914421MGST2F1PFR5Reactome DB_ID: 9914419UniProt:F1PFR5UniProtF1PFR51EQUAL147EQUALReactome Database ID Release 729914419Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914419ReactomeR-CFA-1760581Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-176058.13Reactome Database ID Release 729914421Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914421ReactomeR-CFA-1760611Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-176061.1MGST3 trimerReactome DB_ID: 9914427MGST3MGST3E2RP74Reactome DB_ID: 9914425UniProt:E2RP74MGST3UniProtE2RP741EQUAL152EQUALReactome Database ID Release 729914425Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914425ReactomeR-CFA-1760531Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-176053.13Reactome Database ID Release 729914427Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914427ReactomeR-CFA-1760471Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-176047.1Reactome Database ID Release 729914429Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914429ReactomeR-CFA-1760421Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-176042.1GENE ONTOLOGYGO:0004364Reactome Database ID Release 729914430Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914430Reactome Database ID Release 729914432Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914432ReactomeR-CFA-1760591Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-176059.1The microsomal glutathione S-transferases (MGSTs) catalyse the nucleophilic attack by reduced glutathione (GSH) on nonpolar compounds that contain an electrophilic C, N, or S atom. Three major families of proteins are widely distributed in nature. The cytosolic and mitochondrial GST families comprise soluble enzymes that are only distantly related whilst the third family comprises microsomal GST, referred to as membrane-associated proteins in eicosanoid and glutathione (MAPEG) metabolism. Three members of this family function as detoxification enzymes, MGST1-3 (DeJong et al. 1988, Kelner et al. 1996, Jakobsson et al. 1996, Jakobsson et al. 1997). Electron crystallography studies in rat Mgst1 indicate these enzymes function as homotrimers (Holm et al. 2002). Both aflatoxin B1 exo- and endo-epoxides (AFXBO and AFNBO) conjugate with glutathione. These conjugates are eventually excreted in urine as mercapturic acids.8812420Pubmed1996Structural organization of the human microsomal glutathione S-transferase gene (GST12)Kelner, M JStokely, M NStovall, N EMontoya, M AGenomics 36:100-311904223Pubmed2002The 3-D structure of microsomal glutathione transferase 1 at 6 A resolution as determined by electron crystallography of p22(1)2(1) crystalsHolm, Peter JMorgenstern, RHebert, HBiochim. Biophys. Acta 1594:276-853372534Pubmed1988Gene expression of rat and human microsomal glutathione S-transferasesDeJong, J LMorgenstern, RJörnvall, HansDePierre, J WTu, C PJ. Biol. Chem. 263:8430-68703034Pubmed1996Identification and characterization of a novel human microsomal glutathione S-transferase with leukotriene C4 synthase activity and significant sequence identity to 5-lipoxygenase-activating protein and leukotriene C4 synthaseJakobsson, P JMancini, J AFord-Hutchinson, A WJ. Biol. Chem. 271:22203-109278457Pubmed1997Identification and characterization of a novel microsomal enzyme with glutathione-dependent transferase and peroxidase activitiesJakobsson, P JMancini, J ARiendeau, DFord-Hutchinson, A WJ. Biol. Chem. 272:22934-9LEFT-TO-RIGHT2.5.1.18Glutathione conjugation of cytosolic substratesGST dimers conjugate GSH with cytosolic substratesThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Converted from EntitySet in ReactomeElectrophilic substrateReactome DB_ID: 176070BPDEBenzo(a)pyrene-7,8-diol 9,10-epoxidebenzo[a]pyrene diol epoxide IReactome DB_ID: 159245benzo[a]pyrene diol epoxide I [ChEBI:30614]benzo[a]pyrene diol epoxide I(+/-)-Anti-benzo(a)pyrenediol epoxide(+/-)-Benzo(a)pyrene-7,8-diol-9,10-epoxide, anti-BPDEtrans-7,8-Dihydroxy-anti-9-10-epoxy-7,8,9,10-tetrahydrobenzo(a)pyreneChEBICHEBI:30614Reactome Database ID Release 72159245Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=159245ReactomeR-ALL-1592453Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-159245.3NABQIN-AcetylbenzoquinoneimineN-acetyl-1,4-benzoquinone imineReactome DB_ID: 176067Reactome Database ID Release 72176067Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=176067ReactomeR-ALL-1760673Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-176067.3CDNB1-chloro-2,4-dinitrobenzeneReactome DB_ID: 1760441-chloro-2,4-dinitrobenzene [ChEBI:34718]1-chloro-2,4-dinitrobenzeneDNCB6-Chloro-1,3-dinitrobenzeneCdnb2,4-Dinitro-1-chlorobenzeneChlorodinitrobenzeneDinitrochlorobenzene1,3-Dinitro-4-chlorobenzeneDncb1-Chloro-2,4-dinitrobenzol2,4-Dinitrochlorobenzene4-Chloro-1,3-dinitrobenzene2,4-Dinitrophenyl chlorideChEBICHEBI:34718Reactome Database ID Release 72176044Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=176044ReactomeR-ALL-1760443Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-176044.3Reactome Database ID Release 72176070Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=176070ReactomeR-ALL-1760701Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-176070.1Converted from EntitySet in Reactomeelectrophilic substrate:SGReactome DB_ID: 176049BPD-SG conjugateBenzo(a)pyrene-7,8-diol-glutathione conjugate7,8-dihydro-7-hydroxy-8S-glutathionylbenzo[a]pyreneReactome DB_ID: 1592477,8-dihydro-7-hydroxy-8S-glutathionylbenzo[a]pyrene [ChEBI:34479]7,8-dihydro-7-hydroxy-8S-glutathionylbenzo[a]pyrene7,8-Dihydro-7-hydroxy-8-S-glutathionyl-benzo[a]pyreneChEBICHEBI:34479Reactome Database ID Release 72159247Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=159247ReactomeR-ALL-1592473Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-159247.3ACAP-GSHacetaminophen glutathione conjugateReactome DB_ID: 177721Reactome Database ID Release 72177721Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=177721ReactomeR-ALL-1777213Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-177721.3DNPSG2,4-dinitrophenyl-S-glutathioneS-(2,4-dinitrophenyl)glutathioneReactome DB_ID: 176056S-(2,4-dinitrophenyl)glutathione [ChEBI:8927]S-(2,4-dinitrophenyl)glutathioneChEBICHEBI:8927Reactome Database ID Release 72176056Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=176056ReactomeR-ALL-1760563Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-176056.3Reactome Database ID Release 72176049Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=176049ReactomeR-ALL-1760491Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-176049.1ACTIVATIONConverted from EntitySet in ReactomeGST dimersReactome DB_ID: 9914406GSTA1 dimerReactome DB_ID: 9914340GSTA1LOC474938J9NRX4Reactome DB_ID: 9914338UniProt:J9NRX4LOC474938UniProtJ9NRX42EQUAL222EQUALReactome Database ID Release 729914338Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914338ReactomeR-CFA-1760501Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-176050.12Reactome Database ID Release 729914340Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914340ReactomeR-CFA-33019321Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-3301932.1GST A4 dimerReactome DB_ID: 9914346GSTA4GSTA4E2REA5Reactome DB_ID: 9914344UniProt:E2REA5GSTA4UniProtE2REA51EQUAL222EQUALReactome Database ID Release 729914344Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914344ReactomeR-CFA-1592041Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-159204.12Reactome Database ID Release 729914346Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914346ReactomeR-CFA-1592021Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-159202.1GSTM1 dimerReactome DB_ID: 9914352GSTM1LOC479912F1Q3C4Reactome DB_ID: 9914350UniProt:F1Q3C4LOC479912UniProtF1Q3C42EQUAL218EQUALReactome Database ID Release 729914350Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914350ReactomeR-CFA-1592011Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-159201.12Reactome Database ID Release 729914352Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9914352ReactomeR-CFA-33019491Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-3301949.1GSTM3 dimerReactome DB_ID: 9914358GSTM3GSTM3E2R5B9