As part of the relocation, a new four-lane, limited access roadway would be constructed from the U.S. 50/Red Bank Road interchange to just west of the I-275 Eastgate exit.

One proposal routes the roadway through a portion of Mariemont referred to as the South 80, where last year University of Cincinnati archaeology assistant professor Ken Tankersley discovered the remnants of a Native American village that dates to the Fort Ancient culture. He has also discovered what he believes to be a 2,952-foot-long serpent mound, which would make it the largest prehistoric earthwork of its kind in the United States.

In addition to impacts to the Village of Mariemont, which is a National Historic Landmark, effects could be seen in Anderson Township and the villages of Newtown and Fairfax.

The estimated $366 million road project is currently in the environmental engineering phase. Last month, ODOT's Transportation Review Advisory Council pledged $3.6 million for preliminary engineering in fiscal year 2014.