WINE 1.2 has been released, the new version including (finally!) 64bit application support:

Loading and running 64-bit Windows applications is now supported on x86-64 processors.

There are now two flavors of Wine prefixes, 32-bit and 64-bit. 32-bit prefixes only support 32-bit applications, while 64-bit prefixes support both 32-bit and 64-bit applications. The prefix flavor is set at prefix creation time and cannot be changed afterwards, since all the files and registry entries are in different locations. Backwards compatibility is ensured by considering all prefixes created with older Wine versions to be 32-bit.

The new version comes with 23,000 changes and more than 3,000 bug-fixes and a new icon set based on Tango.