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World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar. Best Paper Award : Dr. Muhammad Baqir MR Fakhrildin
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Abstract

A wide spectrum of cutaneous manifestations ranging from
maculopapular rashes to toxic epidermal necrolysis (TEN), considered
being two ends of a spectrum of severe epidermolytic adverse
cutaneous drug reactions can be caused by different classes of
antibiotics. Toxic epidermal necrolysis (TEN) and Stevens Johnson
Syndrome (SJS) are characterized by mucocutaneous tenderness and
typically hemorrhagic erosions, erythema and more or less severe
epidermal detachment presenting as blisters and areas of denuded skin.
Our prospective descriptive hospital -based study aimed to determine
the prevalence of epidermolytic adverse cutaneous drug reactions
among other cutaneous adverse drug reactions due to systemic
antibiotics with highlights on onset and mucous membranes affection
in Sudanese patients attended Khartoum Dermatology and Venereal diseases Teaching
Hospital – Sudan. Mucous membranes' affection existed in 100 % of patients. Ocular along
with oral mucosal affections were the predominant sites. Percentages of only oral affection,
mouth and genitalia, mouth and eyes, eyes and genitalia, all mucous membranes, eyes alone,
and genitalia alone were 34.1%, 22%, 14.6%, 12.2%, 12.2%, 2.4%, and 2.4%% respectively.
Epidermolytic adverse cutaneous eruption represented 58.6% of all cutaneous drug reactions
due to antibiotics. It was concluded that epidermolytic adverse cutaneous drug eruptions are
common cutaneous adverse drug reactions (CADRs) and represented 58.6% of all cutaneous
drug reactions due to antibiotics. Ocular along with oral mucosal membranes (41.5 % and 34.1%) were the predominant sites of mucosal affection. Onset of < 1 week after offending drug administration was seen in most of patients (53.7%).