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I'm also having the same problem where the dpmdsacl.exe application crashes when trying to update the schema. I have tried running the schema update from the DPM management GUI and also by logging onto the schema master DC and running DPMADSchemaExtension.exe but I get the same results. I've also tried running as an administrator but no dice. I'm running a new install of DPM 2012 R2, our AD forest is Server 2008 R2. I had played around with DPM 2010 a couple years ago and may have extended the schema back then if that makes a difference.

Thanks mniccum. Glad to know I'm not the only one seeing this problem.
It appears that I've found a band-aid for now. I spun up a new VM and made it a new distribution point with the PXE role in my SCCM environment. After a few hours of syncing packages, I'm now able to boot from it and run task sequences. It's not a perfect solution, and I would still like to fix my primary server, but at least I have a method to pxe boot and image machines now. This also rules out a corrupted boot image, since creating a new distribution point would have simply copied from the same source.
Perhaps we'll find out more information as more people upgrade to R2.