This paper reviewed the design of a large-scale clinical trial comparing lithium and quetiapine in bipolar disorder. It would be relevant for anyone desiring a more complete understanding of study design, particularly in bipolar disorders.

Readers will get a better understanding of the thought processes behind the design of a major treatment study. This may lead to improved understanding of the results of such large scale trials.

This publication provides the reader with a more comprehensive understanding of research designs in Psychiatry.