I see the jealous competition down vote train has hit the product ratings at Nutraplanet.

I'm not trying to play devil's advocate here but what about the others who voted and gave the product a 5 star review with out even trying the product yet? Isn't that the same? It's really a shame either way because you have the haters and the nut huggers voting without even trying the product and giving it a fair chance.

I really am looking forward to reading some honest unbiased reviews soon to see if this is a good product or not.

I'm not trying to play devil's advocate here but what about the others who voted and gave the product a 5 star review with out even trying the product yet? Isn't that the same? It's really a shame either way because you have the haters and the nut huggers voting without even trying the product and giving it a fair chance.

I really am looking forward to reading some honest unbiased reviews soon to see if this is a good product or not.

Absolutely. I'm not a fan of either. Shame that's how it goes on retail sites though. I think that's why AM ended up putting up the "Product Review" section.

I see the jealous competition down vote train has hit the product ratings at Nutraplanet.

Someone really loves you Matt. Every product you release is hit with the one star attack bandwagon before release. "Matt has a new product not out yet. To the 1 star mobile! We must attack early and often!"

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LXR and RXR are my research goals for the summer. Might have to hit you up.

Fun. Lotta awesome implications in the research, if you're willing to connect the dots. My thesis is on the interplay of nuclear receptors with proliferation/regeneration pathways. Very fascinating, especially in the liver, intestine and macrophages of all things.

Fun. Lotta awesome implications in the research, if you're willing to connect the dots. My thesis is on the interplay of nuclear receptors with proliferation/regeneration pathways. Very fascinating, especially in the liver, intestine and macrophages of all things.

More research indicating activity of PPAR delta and osteoblasts. Again I will be working up a more in-depth writeup to cover the interplay between the PPAR-delta angle and Carnitine Fumarate choice for DCP 2.0 as the month continues.

Peroxisome proliferator-activated receptors (PPARs) act as metabolic sensors and central regulators of fat and glucose homeostasis. Furthermore, PPARγ has been implicated as major catabolic regulator of bone mass in mice and humans. However, a potential involvement of other PPAR subtypes in the regulation of bone homeostasis has remained elusive. Here we report a previously unrecognized role of PPARβ/δ as a key regulator of bone turnover and the crosstalk between osteoblasts and osteoclasts. In contrast to activation of PPARγ, activation of PPARβ/δ amplified Wnt-dependent and β-catenin-dependent signaling and gene expression in osteoblasts, resulting in increased expression of osteoprotegerin (OPG) and attenuation of osteoblast-mediated osteoclastogenesis. Accordingly, PPARβ/δ-deficient mice had lower Wnt signaling activity, lower serum concentrations of OPG, higher numbers of osteoclasts and osteopenia. Pharmacological activation of PPARβ/δ in a mouse model of postmenopausal osteoporosis led to normalization of the altered ratio of tumor necrosis factor superfamily, member 11 (RANKL, also called TNFSF11) to OPG, a rebalancing of bone turnover and the restoration of normal bone density. Our findings identify PPARβ/δ as a promising target for an alternative approach in the treatment of osteoporosis and related diseases.

PMID:23542786 [PubMed - in process]

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why? reduce dosage of og? 2.0? or both? also, would stacking with other bitter melon products provide additional benefits or is there a point where more bitter melon gives diminishing results or sides?