The cell cycle has many regulatory mechanisms, the alteration of one of these could cause havoc, such as cancer. The protein of Retinoblastoma (RB) is very important in the interface before beginning mitosis. Would it be believed that the RB protein located on chromosome 13 band q14 is more likely that have a mutation, or is it more likely to be denatured by the diverse human papillomavirus (HPV) group? So in any of the two cases which part of the cycle is affect?