Entasis Therapeutics to Present Data on ETX2514 and ETX0282 at ASM Microbe 2018

June 6, 2018

WALTHAM, Mass.--(BUSINESS WIRE)--Jun 6, 2018--Entasis Therapeutics, a clinical-stage biopharmaceutical company focused on the discovery and development of novel antibacterial products, today announced multiple presentations at the American Society of Microbiology (ASM) Microbe 2018 Conference, taking place June 7-11 in Atlanta, GA. Presentations will include clinical and preclinical data on ETX2514, a novel broad spectrum β-lactamase inhibitor being developed in combination with sulbactam to treat Acinetobacter baumannii infections, and ETX0282, a novel, broad spectrum oral β-lactamase inhibitor being developed in combination with cefpodoxime proxetil to treat infections caused by multidrug-resistant (MDR) Gram-negative pathogens, including multidrug-resistant and carbapenem-resistant Enterobacteriaceae (CRE).

About ETX2514SUL
ETX2514 is a novel broad-spectrum intravenous inhibitor of class A, C and D β-lactamases. ETX2514 restores the in vitro activity of multiple β-lactams against Gram-negative, multidrug-resistant pathogens. Entasis is initially developing ETX2514SUL, a fixed-dose combination of ETX2514 and sulbactam, for the treatment of a variety of serious multidrug-resistant infections caused by A. baumannii. Sulbactam is a generic β-lactam that has intrinsic antibacterial activity against A. baumannii but suffers from widespread β-lactamase-mediated resistance. In preclinical studies, ETX2514 restored sulbactam antibacterial activity against A. baumannii. ETX2514 has completed single- and multi-ascending dose Phase 1 trials. The U.S. Food and Drug Administration has granted Qualified Infectious Disease Product (QIDP) designation and Fast Track designation to ETX2514SUL for the treatment of hospital-acquired and ventilator-acquired bacterial pneumonia and bloodstream infections due to A. baumannii.

About ETX0282CPDP
ETX0282 is an orally available, broad spectrum inhibitor of class A and C β-lactamases. Entasis is developing ETX0282 in combination with cefpodoxime proxetil, an orally available cephalosporin approved for treatment of a variety of bacterial infections. Cefpodoxime’s clinical utility is currently limited by β-lactamase-mediated resistance. In preclinical studies, ETX0282 restored cefpodoxime’s antimicrobial activity against a variety of pathogens, including Enterobacteriaceae resistant to fluoroquinolones, cephalosporins and carbapenems. Entasis is initially developing ETX0282CPDP, the combination of ETX0282 and cefpodoxime proxetil, for the treatment of infections caused by Enterobacteriaceae, including multidrug-resistant and carbapenem-resistant Enterobacteriaceae (CRE). ETX0282CPDP is partially supported by an award from the Combating Antibiotic Resistant Bacteria Biopharmaceutical Accelerator program (CARB-X).

About Entasis Therapeutics Inc.
Entasis is a clinical-stage biopharmaceutical company focused on the discovery, development and commercialization of novel antibacterial products to treat serious infections caused by multidrug-resistant Gram-negative bacteria. Entasis’ targeted-design platform has produced a pipeline of product candidates, including ETX2514SUL (targeting A. baumannii infections), ETX0282CPDP (targeting Enterobacteriaceae infections), and zoliflodacin (targeting Neisseria gonorrhoeae ). Entasis is also using its platform to develop a novel class of non-β-lactam penicillin-binding protein inhibitors (NBPs) targeting Gram-negative infections. For more information, visit www.entasistx.com.