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Get L-Arg And In Charge!

By Admin | Sunday, April 1, 2007 10:04:33 AM America/New_York

Most athletes realize the benefits of a
high-quality L-arginine or
arginine AKG supplement. Indeed it can claim relatively long-term success when taken on its own or in anabolic formulations. Being a conditionally essential amino acid L-arginine serves many important functions throughout the body and new research has found a multitude of reasons for including it in your supplement regime. The following article is a based on a recent publication presented by McConell (2007). The aim of the information contained herein is to provide current and comprehensive scientific support for the benefits of
L-arginine supplementation.

L-arginine basics
Metabolically, L-arginine is integral in transporting, processing, and excreting nitrogen. Furthermore it serves as a much needed substrate for the synthesis of creatine and the potent vasodilator nitric oxide. The formation of nitric oxide (NO) from L-arginine requires an enzyme called nitric oxide synthase (NOS). Vascular endothelial cells (located on the inside of blood vessels) contain the eNOS isoform, which is a key player in vasodilation. Human skeletal muscle fibers contain eNOS and (neuronal) nNOS, with nNOS being expressed more so than eNOS. It has been suggested that nNOS is the form of nitric oxide synthase responsible for regulating exercise metabolism (McConell, 2007).

Benefits of L-arginine with acute supplementation
When L-arginine is supplemented in resting humans, it decreases total peripheral resistance through a substantial positive and dose-dependent impact on NO release. This decrease in vascular resistance is due to robust vasodilation that increases blood flow to peripheral tissues (e.g., skeletal muscle). Supplementation of L-arginine has been associated with health benefits such as, decreased resting mean arterial blood pressure, inhibited platelet aggregation, improvement of endothelium mediated vasodilation, and prevention of atherosclerosis (i.e., hardening arteries) (Bode-Boger et al., 1998). In addition, from a performance perspective, L-arginine supplementation at rest increases plasma growth hormone levels, norepinephrine and epinephrine concentrations, as well as insulin, glucagon, and prolactin levels (Bode-Boger et al., 1999;Maccario et al., 1997;Paolisso et al., 1997).
In a recent investigation, McConell et al. observed that L-arginine infusion greatly increased glucose clearance during prolonged exercise in healthy, young, endurance trained men (McConell et al., 2006); they hypothesized that this metabolic effect was due to a L-arginine-induced increase in skeletal muscle NOS. In the same study, the researchers noted increased glucose release from the liver during exercise with L-arginine supplementation. The authors speculated that since L-arginine results in greater plasma glucose uptake (by skeletal muscle), this may be the signal for greater hepatic glucose release.

What does this mean to the athlete on a day-to-day basis?

Increased blood flow to resting skeletal muscle, resulting in substantially greater post-workout clearance of metabolites and delivery of nutrients. This effect helps to speed recovery and increase in bioavailability of nutrients to trained tissues.

Chronic L-arginine ingestion has the capacity to upregulate mitochondria (the energy "power-houses") in skeletal muscle, resulting in greater substrate utilization.

L-arginine has been shown to increase the growth of blood vessels in skeletal muscle and the heart, resulting in greater capacity to deliver nutrients and remove metabolites during and after your workout.

Over the long-term L-arginine supplementation seems to increase NOS expression which has the ability to increase energy utilization and NO dilatory capacity in skeletal muscle.

In closing, recent science supports the use of
L-arginine supplementation for its acute and chronic health and performance benefits. As with all of your supplement purchases, be certain to choose products from reputable manufacturers that use high quality premium-grade ingredients, ProSource Super AKG is one such product. For those of you that are more advanced and want to take training and recovery to the next level try ProSource's SynthaTrex Xtreme.
Reference List
Bode-Boger SM, Boger RH, Galland A, Tsikas D, & Frolich JC (1998). L-arginine-induced vasodilation in healthy humans: pharmacokinetic-pharmacodynamic relationship. Br J Clin Pharmacol 46, 489-497.