The Powerpuff Girls are three superhero sisters born in the lab of Professor Utonium in Townsville. While he was mixing sugar, spice, and everything nice, Professor was pushed into the vial of Chemical X by his hyperactive chimpanzee lab assistant Jojo. An explosion erupted. When Professor looked up, the Powerpuff Girls levitated before him. Blossom, Buttercup, and Bubbles defend the city of Townsville from utter destruction by the hands of supervillains and giant monsters.

Before Mojo Jojo could unleash his army of cybernetically enchanced battle monkeys, the Powerpuff Girls broke their way into his secret lab and Butterrcup unplugged the monkeys. Mojo blasted them with his Powerpuff Girls Repellent and teleported himself to another dimension to carry out his monkey army plan. In search of Mojo Jojo, the Girls teleported to the other dimension and found themselves in the Titans Tower. Robin, Raven, and Starfire did not take them seriously at first and thought they were just little babies. Raven found a note left by Beast Boy to tell the others he and Cyborg were helping Mojo. But it simply read "Help! Monkeys!" Blossom realized the Titans weren't very good at being superheroes but they took her words as a challenge. Blossom and Robin analyzed the note. She noticed more on the note revealing Beast Boy, Cyborg, and Mojo were at the Zoo. Two gorillas were stationed at the zoo entrance. Starfire and Bubbles got into an argument about letting the other go first. As Starfire's eyes erupted with lasers, Bubbles tilted her towards the guards and fried them.

Buttercup took out the security defenses. Raven declined to join in since she didn't care. Buttercup declared the girls of the winners of the dumb competition but the Titans found her immature and it wasn't a competition. They sprinted towards Mojo's makeshift lair. Thankfully, Robin could hear the Narrator and learned Mojo set a trap. The Titans disguised themselves as the girls and entered. Mojo doused them in the repellent gas but they were unharmed. The real Powerpuff Girls made short work of Mojo with a right punch, kick, and uppercut. Robin admitted they really were superheroes. Blossom added they couldn't have saved the day without them. The Titans declared themselves the winners of the competition. Buttercup fully realized why Mojo chose this dimension to go to. It was the worst.