Mini-symposium on new insights about how biological systems can be controlled with light. This traceless reagent enables a vast scope of possibilities to elucidate
the yet undiscovered facets of nature. Photoactivatable compounds such as one- and two-photon cages, molecular switches and activatable fluorophores and sensors
represent important tool for studying and control of biologically relevant processes, such as transcription, translation, protein and DNA folding and biological signalling.

PROGRAM

MORNING SESSION

8:50 – 9:00

Invitation and opening remarks (Tomáš SLANINA & Zdeněk HOSTOMSKÝ)

9:00 – 9:45

Plenary talk
Alexander HECKEL

Shedding Light on Nucleic Acids

Research Topic 1: Cages and Switches

09:45 – 10:05

Nikolai GREBENOVSKY

Amphidynamic Materials as Molecular Machines

10:05 – 10:25

Volker HERMANNS

Extending the Photochemical Toolbox

10:25 – 10:45

Janik KAUFMANN

Development of BODIPY-Based Light-Inducible Antisense Oligonucleotides for RNA Processing in Plants

10:45 – 11:05

Coffee break

Research Topic 2: RNA Control

11:05 – 11:25

Patricia MÜLLER

Development of Light-Inducible AntimiRs as Therapeutic Agents

11:25 – 11:45

Robin KLIMEK

Regulation of Non-Coding RNA in Neurons

11:45 – 12:05

Anja BLÜMLER

Chemo-Enzymatic Synthesis of Modified RNA

12:05 – 13:30

Lunch break and discussions

AFTERNOON SESSION

Research Topic 3: Bioorganic Chemistry of Nucleic Acids

13:30 – 14:15

Plenary talk
Michal HOCEK

Modified nucleic acids for diagnostics and chemical biology

14:15 – 14:35

Zuzana VANÍKOVÁ

Switching of enzymatic cleavage of DNA and transcription through photocaging, deprotection and phosphorylation reactions on DNA

Research Topic 4: 2-Photon Activation

14:35 – 14:55

Yvonne BECKER

New Two-Photon Caging Groups and Excitation-Specific Photochemistry

14:55 – 15:15

Rebekka WEBER

Enhanced Two-Photon Uncaging via Intramolecular FRET

15:15 – 15:30

Coffee break

15:30 – 15:50

Tomáš SLANINA

Catch-And-Release: More then bioconjugations

15:50 – 16:35

Plenary talk
Milan VRÁBEL

Bioorthogonal chemistry of heterodienes: Application in bioimaging and beyond