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I have early onset of PD .I am concerned about Dyskinesia…

Customer Question

I have early onset of...

I have early onset of PD .I am concerned about Dyskinesia with long term Dopamine use .Is there any harm if I stop taking the 3 rd dose of my Carbidopa-Levodopa 25-100 to encourage my body to continue making Dopamine .I have several times forgotten to take the last dose with little problem .I have heard Mucuna is a good subsitute with little side effects .

Experience: Board certified general Adult Neurologist, with experience in experimental neuroimaging and neurodiagnostics.

Verified

Hello. Welcome to JA. There is a concern with early parkinsons that using sinemet (LDopa/carbidopa) early in the course will cause receptor hyperplasia and make you more resistant to its effect later on The strategy is to use dopamine agonists initially, only adding sinemet as they become less effective. The two medications usually used initially are ropinerole (requip) or pramipexole (mirapex). Those medications encourage your body to make more dopamine, as opposed to sinemet, that replaces the dopamine that you are not able to make.

I have attached an abstract published in a well known neurology journal showing that Mucuna may have advantages over the use of standard L Dopa/carbidopa preparations. Please get back to me if you have questions. I hope I was able to answer your question, if satisfied, please remember to rate my service by clicking on the rating stars. thank you. *****

Hello. I hope I was able to answer your question. Please get back to me to discuss this further or if satisfied please remember to rate my service by clicking on the rating stars as that is how i am compensated for my work. Thanks dr Frank.

Alex, I hope I was able to answer your question. Please get back to me to discuss this further if I can help, or if satisfied, please remember to rate my service by clicking on the rating stars as that is how I am compensated for this work thanks *****

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Disclaimer: Information in questions, answers, and other posts on this site ("Posts") comes from individual users, not JustAnswer; JustAnswer is not responsible for Posts. Posts are for general information, are not intended to substitute for informed professional advice (medical, legal, veterinary, financial, etc.), or to establish a professional-client relationship. The site and services are provided "as is" with no warranty or representations by JustAnswer regarding the qualifications of Experts. To see what credentials have been verified by a third-party service, please click on the "Verified" symbol in some Experts' profiles. JustAnswer is not intended or designed for EMERGENCY questions which should be directed immediately by telephone or in-person to qualified professionals.