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More Proteins for Centromere Protein H (CENPH) Interaction Partners

Human Centromere Protein H (CENPH) interaction partners

In summary, CENP-H may be involved in cell proliferation and apoptosis of hepatocellular carcinoma (HCC)cells through the mitochondrial apoptotic pathway. Combined with previous studies, the data provide a new perspective on HCC development and progression.

Upregulation of centromere protein H is associated with progression of renal cell carcinoma

propose that CSPP1 cooperates with CENP-H on kinetochores to serve as a novel regulator of kinetochore microtubule dynamics for accurate chromosome segregation

CENP-H was overexpressed in HCC, and its level of upregulation was an independent prognostic indicator, suggesting that CENP-H may be an effective therapeutic strategy for the treatment of HCC.

CENP-H promotes the proliferation of human gastric cancer cells

High expression of CENP-H in gastric cancer indicates poor prognosis and Survivin may mediate its procancer role.

Breast cancer patients with high CENP-H expression had short overall survival. CENP-H expression was related with clinical stage.

upregulated CENP-H and Ki67 levels are significantly associated with short relapse-free survival in hypopharyngeal squamous cell carcinoma (HSSC); these factors may be predictors of a relapsing phenotype in HSSC cases

Sp1 and Sp3 bind to the CENPH minimal promoter and function as a regulator of the transcription of CENPH in nasopharyngeal carcinomas.

CENP-H is up-regulated and plays an important role in the aneuploidy frequently observed in colorectal cancers.

The CENP-H-I complex may function, in part, as a marker directing CENP-A deposition to centromeres.

has an important impact on the architecture and function of the human kinetochore complex

CENP-H has a role in preventing progression of nasopharyngeal carcinoma

CENP-C and CENP-H co-localize to the CENP-A chromatin domain.

the vertebrate KNL1 counterpart is essential for chromosome segregation and is required to localize a subset of outer kinetochore proteins.

Mouse (Murine) Centromere Protein H (CENPH) interaction partners

A novel role of CenpH in regulating meiotic G2/M transition by acting via the APC/C(Cdh1)-cyclin B1 pathway.

Zebrafish Centromere Protein H (CENPH) interaction partners

essential role of cenph in mitosis and embryonic development and its association with tumor development

Centromere Protein H (CENPH) Protein Profile

Protein Summary

Centromere and kinetochore proteins play a critical role in centromere structure, kinetochore formation, and sister chromatid separation. The protein encoded by this gene colocalizes with inner kinetochore plate proteins CENP-A and CENP-C in both interphase and metaphase. It localizes outside of centromeric heterochromatin, where CENP-B is localized, and inside the kinetochore corona, where CENP-E is localized during prometaphase. It is thought that this protein can bind to itself, as well as to CENP-A, CENP-B or CENP-C. Multimers of the protein localize constitutively to the inner kinetochore plate and play an important role in the organization and function of the active centromere-kinetochore complex.