As reported by the L.A. Times, series creator Ryan Murphy confirmed that Rabe would play the famous killer of seven men, who herself was notably earlier played by Charlize Theron in the 2003 film Monster, following the real criminal’s 2002 execution. Whether or not the appearance identifies anything about the Hotel timeline (Wuornos was also prominently based out of Florida, not L.A.), here’s what Murphy had to say:

We’re doing a two-part, well, we always do a two-part Halloween episode, but our Halloween episode this year is called ‘Devil’s Night.’ I’m directing it because I love the script so much, when we finished it I said, ‘I can’t give this to anybody else.’ Lily Rabe is coming to that episode. And she’s playing Aileen Wuornos, which is really fun and bizarre. I don’t want to give too much away but I will tell you that she’s at the centerpiece of that, and that’s who she’s playing.