Abstract

The objective of the present study was to evaluate the modulation of GABA-evoked currents by the flavonoid viscosine at recombinant GABA(A) receptors, and subsequently to study its anxiolytic, sedative and anticonvulsant activities. Viscosine (1-300μM) positively modulated GABA-evoked currents at human α1β2γ2L and α2β2γ2L GABA(A) receptors expressed in… (More)