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What causes an amoxicillin rash? amoxicillin rash. Image credit: Skoch3, (, February 17). Amoxicillin may cause a rash in some people. Some research reports that the antibiotic amoxicillin caused a maculopapular rash in up to 70 percent of people being treated for a viral. We examine 68 different rashes, including images and links to more detailed Also, some medications, including some antibiotics, cause.