Yes, this is a fantasy site. But it has an unbelievably detailed breakdown (with easy-to-review table presentation) of what has happened to all the top high-carry NFL RBs following their work horse exposures..........and, with very isolated exception, it's not very good news at all. If it teaches you anything, it is that the human body has it's limitations.

Some more numbers including additional players that didn't quite reach the 390 carries, but were pretty high up there. The pattern is still disturbing.