3D Coat

Best known for: Voxel sculpting for topology-less sculpting, texture painting and advanced retopology capabilities including auto-retopology which can generate all-quad meshes using nothing more then a few basic guide splines drawn by the user.

Z Brush

Best known for: being well a supported and innovative sculpting package. Zbrush’s Ztool system allows for minimal use of a traditional 3D package, while its tools attempt to bring digital media as close to traditional, physical media as possible.