GREMLIN Results:
Residue pairs sorted by strength in covariance:Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

i

j

Raw Score

Scaled Score

42_Y

90_G

0.61565

3.724

5_S

109_D

0.54832

3.317

31_Y

34_G

0.40672

2.460

65_R

114_E

0.39235

2.373

27_R

46_D

0.34492

2.086

27_R

44_H

0.33495

2.026

69_Q

107_V

0.30348

1.836

29_K

44_H

0.28964

1.752

3_N

6_K

0.2693

1.629

96_S

99_D

0.26905

1.627

64_F

115_V

0.25948

1.570

40_S

90_G

0.24674

1.493

41_V

113_I

0.24364

1.474

28_L

115_V

0.23567

1.426

38_Y

93_S

0.22974

1.390

15_S

27_R

0.22937

1.387

30_V

39_L

0.22924

1.387

34_G

40_S

0.22806

1.380

44_H

88_S

0.22731

1.375

38_Y

96_S

0.22389

1.354

35_N

88_S

0.22026

1.332

18_V

25_P

0.21783

1.318

40_S

94_F

0.21682

1.312

63_R

116_E

0.21538

1.303

12_E

15_S

0.21511

1.301

45_C

56_W

0.21459

1.298

43_L

62_F

0.21446

1.297

19_F

22_G

0.2136

1.292

74_I

77_R

0.21348

1.291

76_K

79_K

0.20905

1.265

8_K

101_E

0.20862

1.262

41_V

64_F

0.20786

1.257

66_L

95_I

0.20649

1.249

26_W

45_C

0.20409

1.235

23_G

26_W

0.20292

1.227

109_D

114_E

0.20103

1.216

71_G

74_I

0.19664

1.189

13_Y

29_K

0.1939

1.173

26_W

58_I

0.19141

1.158

90_G

94_F

0.18468

1.117

95_I

100_L

0.18371

1.111

24_Y

45_C

0.18362

1.111

88_S

91_W

0.18255

1.104

98_E

112_T

0.18091

1.094

24_Y

58_I

0.17647

1.067

62_F

83_F

0.17131

1.036

27_R

47_K

0.17112

1.035

106_L

111_L

0.17112

1.035

99_D

114_E

0.17002

1.028

26_W

60_A

0.1686

1.020

4_F

32_P

0.16508

0.999

60_A

117_V

0.16393

0.992

23_G

28_L

0.1639

0.991

97_W

101_E

0.16129

0.976

70_N

73_S

0.15971

0.966

25_P

45_C

0.15839

0.958

15_S

44_H

0.1579

0.955

61_E

118_K

0.15625

0.945

4_F

106_L

0.15579

0.942

12_E

112_T

0.15552

0.941

20_S

25_P

0.155

0.938

3_N

8_K

0.15393

0.931

73_S

77_R

0.15376

0.930

106_L

109_D

0.15263

0.923

64_F

91_W

0.15239

0.922

41_V

45_C

0.15161

0.917

17_F

20_S

0.15095

0.913

11_E

14_S

0.15073

0.912

4_F

7_L

0.14882

0.900

65_R

116_E

0.14679

0.888

29_K

88_S

0.14561

0.881

45_C

58_I

0.14493

0.877

20_S

23_G

0.1449

0.877

26_W

43_L

0.14474

0.876

88_S

92_S

0.14378

0.870

14_S

27_R

0.1432

0.866

87_S

92_S

0.14275

0.864

24_Y

56_W

0.14228

0.861

81_H

92_S

0.1421

0.860

6_K

113_I

0.14201

0.859

81_H

87_S

0.1406

0.850

67_L

114_E

0.14057

0.850

59_E

82_S

0.14005

0.847

69_Q

112_T

0.13928

0.843

100_L

111_L

0.13916

0.842

101_E

117_V

0.13912

0.842

8_K

23_G

0.13832

0.837

112_T

115_V

0.13822

0.836

101_E

110_S

0.13784

0.834

42_Y

94_F

0.13759

0.832

23_G

50_N

0.1375

0.832

62_F

92_S

0.13714

0.830

81_H

91_W

0.13676

0.827

105_F

108_D

0.13543

0.819

81_H

89_W

0.13542

0.819

29_K

60_A

0.13515

0.818

101_E

111_L

0.13512

0.817

22_G

60_A

0.13472

0.815

36_G

114_E

0.1344

0.813

56_W

62_F

0.13411

0.811

93_S

102_D

0.13333

0.807

23_G

110_S

0.13322

0.806

25_P

46_D

0.13318

0.806

103_P

106_L

0.13189

0.798

79_K

86_P

0.13188

0.798

42_Y

92_S

0.1313

0.794

11_E

115_V

0.1311

0.793

3_N

105_F

0.13055

0.790

19_F

64_F

0.13024

0.788

68_N

101_E

0.12998

0.786

33_K

39_L

0.12948

0.783

15_S

64_F

0.12939

0.783

5_S

95_I

0.12937

0.783

95_I

99_D

0.1289

0.780

78_I

84_N

0.12886

0.779

30_V

41_V

0.12747

0.771

76_K

87_S

0.12713

0.769

24_Y

38_Y

0.12685

0.767

11_E

15_S

0.12604

0.762

80_S

84_N

0.12601

0.762

76_K

80_S

0.125

0.756

37_K

47_K

0.12467

0.754

44_H

100_L

0.12462

0.754

79_K

92_S

0.12387

0.749

5_S

8_K

0.1233

0.746

22_G

47_K

0.12321

0.745

78_I

81_H

0.12287

0.743

32_P

60_A

0.12258

0.741

57_S

82_S

0.12253

0.741

39_L

97_W

0.12232

0.740

19_F

109_D

0.12061

0.730

110_S

118_K

0.12061

0.730

8_K

72_K

0.12061

0.730

96_S

110_S

0.11917

0.721

7_L

39_L

0.1191

0.720

32_P

68_N

0.11893

0.719

6_K

41_V

0.11853

0.717

109_D

112_T

0.11806

0.714

81_H

85_N

0.11773

0.712

19_F

26_W

0.11768

0.712

30_V

64_F

0.11761

0.711

35_N

42_Y

0.11708

0.708

59_E

96_S

0.11693

0.707

28_L

46_D

0.11654

0.705

35_N

98_E

0.11636

0.704

34_G

90_G

0.1159

0.701

21_H

105_F

0.1159

0.701

31_Y

44_H

0.11571

0.700

39_L

58_I

0.11532

0.698

14_S

17_F

0.11521

0.697

38_Y

45_C

0.11503

0.696

110_S

114_E

0.11483

0.695

40_S

64_F

0.11479

0.694

77_R

82_S

0.11468

0.694

29_K

86_P

0.11457

0.693

81_H

88_S

0.11431

0.691

62_F

78_I

0.11378

0.688

34_G

42_Y

0.11376

0.688

39_L

100_L

0.11367

0.688

42_Y

91_W

0.11352

0.687

60_A

65_R

0.11351

0.687

44_H

108_D

0.11334

0.686

60_A

83_F

0.11249

0.680

69_Q

72_K

0.11235

0.680

Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.

HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits: Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)