News

UNC scientists led by John Sondek, PhD, created a new biochemical tool to block specific types of downstream G-protein signaling, opening new avenues of research and potential drug design and discovery.

UNC scientists expand the use of light to control protein activity in cells. Klaus Hahn and Nikolay Dokholyan have published a paper in Science, detailing how they use light- or ligand-sensitive domains to modulate the structural disorder of diverse proteins, thereby generating robust allosteric switches. The title of the paper is "Engineering extrinsic disorder to control protein activity in living cells."