As the world's drug habit shows, governments are failing in their quest to monitor every London window-box and Andean hillside for banned plants. But even that Sisyphean task looks easy next to the fight against synthetic drugs. No sooner has a drug been blacklisted than chemists adjust their recipe and start churning out a subtly different one.

Rob Paulsen won an Emmy as the voice of Pinky, who was responsible for supporting Brain (Maurice LaMarche) in his Sisyphean quest for world domination[…]

"How Life Imitates Chess" by Garry Kasparov, Bloomsbury USA publishing, 2007/2008: pg. 145 (Chapter 12, "The Inner Game"): "You can't overestimate the importance of psychology in chess, and as much as some players try to downplay it, I believe that winning requires a constant and strong psychology not just at the board but in every aspect of your life...It begins with intense preparation, which requires that you motivate yourself to work long, grueling, lonely hours. It often feels like a Sisyphean task, since you know that perhaps only ten percent of your analysis will ever see the light of day."