The $1.3B Quest to Build a Supercomputer Replica of a Human Brain

Even by the standards of the TED conference, Henry Markram’s 2009 TEDGlobal talk was a mind-bender. He took the stage of the Oxford Playhouse, clad in the requisite dress shirt and blue jeans, and announced a plan that—if it panned out—would deliver a fully sentient hologram within a decade. He dedicated himself to wiping out all mental disorders and creating a self-aware artificial intelligence. And the South African–born neuroscientist pronounced that he would accomplish all this through an insanely ambitious attempt to build a complete model of a human brain—from synapses to hemispheres—and simulate it on a supercomputer. Markram was proposing a project that has bedeviled AI researchers for decades, that most had presumed was impossible. He wanted to build a working mind from the ground up.