* In ''Literature/TheBible'' (well, the Book of Tobit, which is in some Bibles) a woman named Sarah has a bad case of this--she is married seven times, but each groom dies before the marriage can be consummated. It turns out [[HornyDevils a demon named Asmodeus is in lust with her]], [[MurderTheHypotenuse and killing all his competition]]; the hero [[KissingCousins and her cousin]], Tobit, marries her and is able to drive the demon away following instructions from the [[GodInHumanForm disguised]] Archangel Raphael. He survives the wedding night while Raphael definitely seals Asmodeus away, and he and Sarah live happily from then on.

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* In ''Literature/TheBible'' (well, the Book of Tobit, which is in some Bibles) a woman named Sarah has a bad case of this--she is married seven times, but each groom dies before the marriage can be consummated. It turns out [[HornyDevils a demon named Asmodeus is in lust with her]], [[MurderTheHypotenuse and killing all his competition]]; the hero [[KissingCousins and ([[KissingCousins her cousin]], Tobit, Tobias), marries her and is able to drive the demon away following instructions from the [[GodInHumanForm disguised]] Archangel Raphael. ArchangelRaphael. He survives the wedding night, to the immense surprise of his new father-in-law, who had spent the night while digging his grave; meanwhile, Raphael definitely seals Asmodeus away, and he and Sarah live happily from then on.the couple lives HappilyEverAfter.

* ''[[VideoGame/FireEmblemAkaneia Fire Emblem: Shadow Dragon]]'' has the in-universe legend of Artemis' Curse - whenever a hero takes up the eponymous [[LuckilyMyShieldWillProtectMe Fire Emblem]] to save the world, he or she is doomed to never be with his or her true love. This goes even worse for the direct descendants of the Archanean royal family, who are cursed to forever live lives of tragedy and doomed relationships due to the founder of Archanea being a thief who stole the Fire Emblem from its sacred temple and sold its pieces to fund his rebellion against the Dolhrian Empire. (Although, the curse doesn't seem to affect Marth or his decendant [[VideoGame/FireEmblemAwakening Chrom]], both of them bearers of the Fire Emblem who have no trouble with their love life, so the legend may well just be a legend.)** Lon'qu from ''VideoGame/FireEmblemAwakening'' deconstructs this. His first friend was a young girl his age, Ke'ri, who was killed by bandits (and apparently in a HeroicSacrifice to save ''him'') while he couldn't do anything to rescue her, becoming his [[TheLostLenore Lost Lenore]]. As a result, he started to believe he suffered from this trope, to the point where he developed gynophobia: he does '''not''' hate anyone of the opposite gender per se, and he leaves it very clear whenever he's asked about it, but [[CannotTalkToWomen cannot bring himself to get close to them]] out of the deep fear that he will get them killed. The only girls he'll approach without much trouble will be either his girlfriend/wife (who generally have to be VERY persistent towards him) and a prospect daughter fathered by him.

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* ''Franchise/FireEmblem'':** ''[[VideoGame/FireEmblemAkaneia Fire Emblem: Shadow Dragon]]'' has the in-universe legend of Artemis' Curse - whenever a hero takes up the eponymous [[LuckilyMyShieldWillProtectMe Fire Emblem]] to save the world, he or she is doomed to never be with his or her true love. This goes even worse for the direct descendants of the Archanean royal family, who are cursed to forever live lives of tragedy and doomed relationships due to the founder of Archanea being a thief who stole the Fire Emblem from its sacred temple and sold its pieces to fund his rebellion against the Dolhrian Empire. (Although, While Marth manages to dodge the curse doesn't seem to affect Marth or and marry his decendant beloved Caeda despite using the Emblem, [[spoiler: Princess Nyna of Archanea]] (who can't use it but hands it to Marth) is hit ''point blank'' [[spoiler: and loses her ''two'' love interests, Hardin and Camus]]; [[VideoGame/FireEmblemAwakening Chrom]], Marth's descendants]] Chrom and [[spoiler: Lucina]], who both of them bearers of wield the Fire Emblem who in one way or another, have no trouble with mixed results since the ones [[spoiler: from the BadFuture]] play it completely straight, whereas those from [[spoiler: the main story]] put an end it since [[spoiler: their love life, so the legend may well just be a legend.)main goal is to avert said BadFuture.]]** Lon'qu from ''VideoGame/FireEmblemAwakening'' ([[spoiler: who can potentially marry Marth's descendant Lissa]]) deconstructs this. His first friend was a young girl his age, Ke'ri, who was killed by bandits (and apparently in a HeroicSacrifice to save ''him'') while he couldn't do anything to rescue her, becoming his [[TheLostLenore Lost Lenore]]. As a result, he started to believe he suffered from this trope, to the point where he developed gynophobia: he does '''not''' hate anyone of the opposite gender per se, and he leaves it very clear whenever he's asked about it, but [[CannotTalkToWomen cannot bring himself to get close to them]] out of the deep fear that he will get them killed. The only girls he'll approach without much trouble will be either his girlfriend/wife (who generally have to be VERY persistent towards him) and a prospect daughter fathered by him.

* Characters who bear the [[TarotMotifs Magician Arcana]] in the ''[[Franchise/ShinMegamiTenseiPersona Persona]]'' series are generally doomed to have short-lived romances. [[VideoGame/{{Persona3}} Junpei's]] love interest [[HeroicSacrifice canonically dies saving his life]] and [[VideoGame/{{Persona4}} Yosuke's]] is the second victim of the SerialKiller that serves as the main villain.

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* Characters who bear the [[TarotMotifs Magician Arcana]] in the ''[[Franchise/ShinMegamiTenseiPersona Persona]]'' series are generally doomed to have short-lived romances. [[VideoGame/{{Persona3}} Junpei's]] love interest [[spoiler: Chidori]] [[HeroicSacrifice canonically dies saving his life]] and [[VideoGame/{{Persona4}} Yosuke's]] crush Saki is the second victim of the SerialKiller that serves as the main villain.

Reason: Eh, if we count the Bad Future, then Chrom DID get hit with it. And let's not forget about Nyna who is THE biggest example of the Curse.

* Wolverine in the ''Film/XMen'' movies. First [[Film/XMenOriginsWolverine Silverfox]], then [[Film/XMenTheLastStand Jean]] (though [[Film/XMenDaysOfFuturePast she's later saved]] via CosmicRetcon). Averted, surprisingly, with [[Film/TheWolverine Mariko]], who ''was'' killed off in the comics.

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* Wolverine in the ''Film/XMen'' movies.''Film/XMenFilmSeries''. First [[Film/XMenOriginsWolverine Silverfox]], then [[Film/XMenTheLastStand Jean]] (though [[Film/XMenDaysOfFuturePast she's later saved]] via CosmicRetcon). Averted, surprisingly, with [[Film/TheWolverine Mariko]], who ''was'' killed off in the comics.

* ''Literature/TheDresdenFiles'': Harry Dresden. One ex he thought was both dead and evil (she came back, briefly), one woman who was turned halfway into a monster (and who he has to kill in a HumanSacrifice in ''Changes''), and a woman who was revealed to have been brainwashed into falling for him. And when the poor guy makes a date for drinks and maybe some casual sex, ''he's'' the one to get killed. Guy can't catch a break.

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* ''Literature/TheDresdenFiles'': Harry Dresden. One ex he thought was both dead and evil (she came back, briefly), one woman who was turned halfway into a monster (and who he has to kill in a HumanSacrifice in ''Changes''), the shadow of a [[OurDemonsAreDifferent Fallen Angel]] who sacrificed herself to save him right as she realized she '''had''' fallen in love with him, and a woman who was revealed to have been brainwashed into falling for him. him. And when the poor guy makes a date for drinks and maybe some casual sex, ''he's'' the one to get killed. Guy can't catch a break.

* ''[[VideoGame/FireEmblemAkaneia Fire Emblem: Shadow Dragon]]'' has the in-universe legend of Artemis' Curse - whenever a hero takes up the eponymous Fire Emblem to save the world, he or she is doomed to never be with his or her true love. This goes even worse for the direct descendants of the Archanean royal family, who are cursed to forever live lives of tragedy and doomed relationships due to the founder of Archanea being a thief who stole the Fire Emblem from its sacred temple and sold its pieces to fund his rebellion against the Dolhrian Empire.

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* ''[[VideoGame/FireEmblemAkaneia Fire Emblem: Shadow Dragon]]'' has the in-universe legend of Artemis' Curse - whenever a hero takes up the eponymous [[LuckilyMyShieldWillProtectMe Fire Emblem Emblem]] to save the world, he or she is doomed to never be with his or her true love. This goes even worse for the direct descendants of the Archanean royal family, who are cursed to forever live lives of tragedy and doomed relationships due to the founder of Archanea being a thief who stole the Fire Emblem from its sacred temple and sold its pieces to fund his rebellion against the Dolhrian Empire. (Although, the curse doesn't seem to affect Marth or his decendant [[VideoGame/FireEmblemAwakening Chrom]], both of them bearers of the Fire Emblem who have no trouble with their love life, so the legend may well just be a legend.)

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* [[CasanovaWannabe Lowell]] from ''VideoGame/TheLastStory'' is revealed to suffer from this in an [[GuideDangIt easily-missed]] optional scene. Every woman he's ever gotten serious with has died some way or another, be it from [[StuffedIntoTheFridge an unprecedented bandit raid]], or [[InstantIllness suddenly contracting a fatal illness]], or something else. This "living hell", as he describes it, has haunted him for most of his life, [[HeroicBSOD breaking him more than once]], and he lives in constant fear of falling in love with someone (or someone else falling in love with him) and them subsequently dying horribly. Rather than isolate himself and spend his life alone, he's resolved himself to be a playboy who flirts around but never lets anything "deep or serious" come of it. [[spoiler:[[LadykillerInLove It doesn't last.]] Although, [[ZigZaggingTrope nothing bad happens to his new love interest.]]]]

*** The problems with Beltorchika were more due to the extremely TroubledProduction nature of ''Zeta'' and less due to anything pertaining to the plot. Her voice actress Creator/MariaKawamura ended up being a tip of a Love Triangle between the director/scriptwriter Creator/YoshiyukiTomino and art director/character designer Creator/MamoruNagano, both (in)famous for being [[PrimaDonnaDirector difficult to work with]], and who, to add injury to the insult, constantly clashed due to the CreativeDifferences. She was cut out simply to ease the things a bit. In the Tomino's original novels the character's ended up as Amuro's ''wife'' after all.

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*** The problems with Beltorchika were more due to the extremely TroubledProduction nature of ''Zeta'' and less due to anything pertaining to the plot. Her voice actress Creator/MariaKawamura ended up being a tip of a Love Triangle LoveTriangle between the director/scriptwriter Creator/YoshiyukiTomino and art director/character designer Creator/MamoruNagano, both (in)famous for being [[PrimaDonnaDirector difficult to work with]], and who, to add injury to the insult, constantly clashed due to the CreativeDifferences. She was cut out simply to ease the things a bit. In the Tomino's original novels the character's ended up as Amuro's ''wife'' after all.

*** The problems with Beltorchika were more due to the extremely TroubledProduction nature of ''Zeta'' and less due to anything pertaining to the plot. Her voice actress Creator/MariaKawamura ended up being a tip of a Love Triangle between the director/scriptwriter Creator/YoshiyukiTomino and art director/character designer Creator/MamoruNagano, both (infamous) for being [[PrimaDonnaDirector difficult to work with]], and who, to add injury to the insult, constantly clashed due to the CreativeDifferences. She was cut out simply to ease the things a bit. In the Tomino's original novels the character's ended up as Amuro's ''wife'' after all.

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*** The problems with Beltorchika were more due to the extremely TroubledProduction nature of ''Zeta'' and less due to anything pertaining to the plot. Her voice actress Creator/MariaKawamura ended up being a tip of a Love Triangle between the director/scriptwriter Creator/YoshiyukiTomino and art director/character designer Creator/MamoruNagano, both (infamous) (in)famous for being [[PrimaDonnaDirector difficult to work with]], and who, to add injury to the insult, constantly clashed due to the CreativeDifferences. She was cut out simply to ease the things a bit. In the Tomino's original novels the character's ended up as Amuro's ''wife'' after all.

** It's more of a love/extremely close female friend dies mid-season to spurn the protagonist to greater heights, though almost exclusively in early UC and ''SEED''. ''Anime/MobileSuitGundam'' has Lalah and Sayla for Amuro (though she doesn't die, due to problems with her VA, she was dropped rather than recast), ''Anime/MobileSuitZetaGundam'' has Beltorchika for Amuro (vanished) and Four and Rosamia for Kamille (dead due to enormous, as opposed to giant, robot), ''Anime/MobileSuitGundamZZ'' has Puru and Puru two, whom both die due to enormous robot. ''SEED'' has Flay for Kira, who dies, and ''Destiny'' has Stella for Shinn, once more due to enormous robot. ''Anime/MobileSuitGundamIronBloodedOrphans'' has Carta Issue, dead due to enormous robot, except her case was a [[UriahGambit betrayal]] staged by [[KillTheOnesYouLove none other than her love interest]].

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** It's more of a love/extremely close female friend dies mid-season to spurn the protagonist to greater heights, though almost exclusively in early UC and ''SEED''. ''Anime/MobileSuitGundam'' has Lalah and Sayla for Amuro (though she doesn't die, due to problems with her VA, she was dropped rather than recast), ''Anime/MobileSuitZetaGundam'' has Beltorchika for Amuro (vanished) ([[PutOnABus vanished]], though only in the anime[[note]]She ''married'' Amuro in the novels — after all, the novel the ''Char's Counterattack'' is based on, is called "Beltorchika's children"[[/note]], and [[TheBusCameBack returned]] in ''[[Anime/MobileSuitGundamUnicorn Unicorn]]'') and Four and Rosamia for Kamille (dead due to enormous, as opposed to giant, robot), ''Anime/MobileSuitGundamZZ'' has Puru and Puru two, whom both die due to enormous robot. ''SEED'' has Flay for Kira, who dies, and ''Destiny'' has Stella for Shinn, once more due to enormous robot. ''Anime/MobileSuitGundamIronBloodedOrphans'' has Carta Issue, dead due to enormous robot, except her case was a [[UriahGambit betrayal]] staged by [[KillTheOnesYouLove none other than her love interest]].interest]].*** The problems with Beltorchika were more due to the extremely TroubledProduction nature of ''Zeta'' and less due to anything pertaining to the plot. Her voice actress Creator/MariaKawamura ended up being a tip of a Love Triangle between the director/scriptwriter Creator/YoshiyukiTomino and art director/character designer Creator/MamoruNagano, both (infamous) for being [[PrimaDonnaDirector difficult to work with]], and who, to add injury to the insult, constantly clashed due to the CreativeDifferences. She was cut out simply to ease the things a bit. In the Tomino's original novels the character's ended up as Amuro's ''wife'' after all.

* Caitlyn from Arrow's spin-off Series/TheFlash2014 doesn't fare much better. Her first love interest, Robbie Amell, is dead at the start of the show, comes back, and then sacrifices himself to save the world. Her second love interest, Jay Gerrick, dies violently in front of her a while later - but it later turns out that he [[FakingTheDeath faked his death]] because he's actually the season's [[BigBad main villain]], Zoom (Hunter Zolomon). He [[spoiler: kidnaps her]], gets defeated by the good guys, and is murdered by [[ClockRoaches Time Wraiths]].

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