The animated series took a number of liberties from the original comics:

Richie is depicted as slightly older, inconsistently voiced as a child between 10 and 13, and wears a red sweater with a large "R" on the front as well as long trousers. In the comics, he wears a black suit with a red bow tie and short pants.

Gloria is shown as the same age as Richie and wears a white long-sleeved blouse, purple sweater or sweater vest and purple mini skirt.

Irona The Robot Maid is given a greater presence in the series with additional duties as Richie's personal bodyguard as seen in the "Zillion Dollar Adventures" segments. To fulfill that role, Irona can convert her body into various alternative modes as necessary. For instance, the moment she receives a summons from Richie, she would change her body into a jet plane mode and immediately fly to the boy.