Having trouble with taking Pristiq

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I am currently taking Pristiq 50mg in the afternoon around 6:00 because I have to take my Adderell XR 25mg (think i spelled that wrong) in the morning. The first two weeks of taking Pristiq I felt awesome was back to my old self again. But after that I just went downhill now all I want to do is sleep, can't stay awake at all. I am not sure what could be wrong nothing has changed in my medication.

I just want to know what is going on will the tiredness ever go away? I have not had the energy to do anything but lie around and sleep. Also I am on pain medication for my back and knees and they are not working like they use to after I had taken the Pristiq for two weeks also.

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I had the same problem with adderall xr and pristiq. The extreme sleepiness and too calm to move feeling is an interaction between adderall xr and pristiq. The norepinephrine re uptake property in the pristiq and the NRI property in the adderall will actually cancel each other out, resulting in that really weird tired/calm feeling. You didn't notice it for a couple of weeks because it takes a couple of weeks for the pristiq to create a constant blood plasma level. Therefore, since you were taking the medications at opposite times, they did not start to interact for a couple of weeks. My doctor switched me to adderall IR twice daily and I no longer experience this side effect at all.

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I've been on pristine for 2weeks now is suiting better than all other meds I've tried only getting four hours sleep a night isn't really bothering me because I feel I've slept for at least 8 hours it's the clenching of the jaw and grinding my teeth in my sleep that is driving me insane my whole mouth n head hurt for 1St few hours awake

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I have been on pristiq for 3 months at 50mg...I have not noticed anything positive but some serious headaches and my BP has increased from 121/79 to 149/84. My doctor just increased my pristiq to 100mg and put me on risperdall (not sure of the spelling). I am not feeling any different. I still have massive anxiety. The best way to describe me is...im the ball in a pin ball machine. i dont feel grounded and find it impossible to set structure for myself. Its driving me crazy. My memory is horrible. I lose everything and cannot stay focused. I am becoming extremely frustrated with all these meds. Should i go see another doctor of just except my life instability in my life? I have been struggling with this for years.....NO help. Well...except once i was put on adderall and it was the best i ever felt in my life until my anxiety kicked in and it became to much for me to handle. Whats your opinion...what would you do?

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Give it time the first little boost in mood is not the effective part that comes later several weeks a gradual improvement in mood, and if you stay on it at least a year most people (about 80% or more) )recover from the depression completely, if it is a Major Depressive Disorder.

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I am curious on if I am going to have the same problems. I wish you luck as starting today I am on Adderall 15mg in the morning, pain medications, Pristiq I just began taking tonight and then if I can not sleep Xanax or Temazepam. I haven't taken Temazepam as I need to be able to wake up in the middle of the night with my two children as my husand works nights. I have had a problem with depression in the past but most recently it has been brought on by my pain and then a hystrectomy at age 29. I have read via internet posts etc that this is a combo that has worked for others. I would possibly speak with your doctor about getting on an alternate drug to Adderrall and seeing if that helps at all. I know in the past if I have been on something for a extended amount of time or in combo with some things loses its effectiveness

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im a paramedic student but what i have learned is there synapes that take place with pain receptors which allow u too feel pain. i think what might be happening is the the drug pristiq ,which also blocks certain chemicals is stronger then the opiod antagonist-(which prevents u from feeling pain is being taken by the place of pristiq) therefore it is not allowing the drug to block ur pain .

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