In vitro studies identified an inhibitor of relA that could
help treat Gram-positive bacterial infections. relA synthesizes
(p)ppGpp, which is required for a bacterial starvation survival mechanism
called the stringent response. In enzymatic assays, a 2ʹ-deoxyguanosine-based analog of (p)ppGpp, dubbed Relacin,
inhibited relA and prevented synthesis of (p)ppGpp from Escherichia coli
and Deinococcus radiodurans. In spore-forming Bacillus subtilis
cells, the analog also decreased (p)ppGpp production, cell viability and
sporulation compared with no treatment. Next steps include determining the
effects of Relacin on eukaryotic cells and examining antibiotic activity in
animal models.

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