Pregnenolone has been called "the grandmother of all steroid hormones." The body manufactures it from cholesterol, and then uses it to make testosterone, cortisone,
progesterone
, estrogen,
DHEA
,
androstenedione
, aldosterone, and all other hormones in the "steroid" family.

One reason given for using pregnenolone is that the level of many of these hormones declines with age. By taking pregnenolone supplements, proponents say, you can keep all your hormones at youthful levels. However, pregnenolone levels themselves don't decline with age,
1
and there is no indication that taking extra pregnenolone will increase the levels of any other hormones. Furthermore, even if it did, that doesn't mean using pregnenolone is a great idea.

Steroid hormones are powerful substances, and they can cause harm as well as benefit. Long-term use of cortisone causes severe
osteoporosis
; estrogen can increase the risk of cancer; and anabolic steroids (used by athletes) may cause liver problems and stress the heart. We really have very little idea what long-term consequences the use of pregnenolone might entail.

Actually, it is ironic that pregnenolone is legally classified as a "dietary supplement" at all. Pregnenolone is not a nutrient. It is a drug, just as estrogen, cortisone, and aldosterone are drugs. We recommend not using it until we know more about what it really does.

At present, there is only one effect of pregnenolone that has been documented via
double-blind, placebo-controlled
studies: for reasons that are not at all clear, regular use of pregnenolone may
greatly
decrease the sedative effect of drugs in the Valium family.
4

Sources

Pregnenolone is not normally obtained from foods. Your body manufactures it
from cholesterol. Supplemental pregnenolone is made synthetically in a lab from substances found in soybeans.

Therapeutic Dosages

A typical recommended dosage of pregnenolone is 30 mg daily, but some studies
have used as much as 700 mg.

Safety Issues

Pregnenolone is a powerful hormone, not a nutrient we would naturally get in
our food. You should approach this supplement with caution, as if it were a
drug. For all intents and purposes, it
is
a drug. It would be best to
consult your doctor before taking it. Pregnenolone is definitely not recommended
for children, pregnant or nursing women, or those with liver or kidney disease.

As noted above, pregnenolone may decrease the effectiveness of sedatives in the Valium family (benzodiazepines). This means that if you are using benzodiazepine drugs for sleep or for anxiety, they may not work as well.

Interactions You Should Know About

If you are using:

Drugs in the
benzodiazepine
family: Pregnenolone may decrease their effectiveness.

Revision Information

This content is reviewed regularly and is updated when new and relevant evidence is made available. This information is neither intended nor implied to be a substitute for professional medical advice. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with questions regarding a medical condition.