Insulin-Like Growth Factor Binding Protein 3 Proteins (IGFBP3)

IGFBP3 is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. Additionally we are shipping IGFBP3 Antibodies (194) and IGFBP3 Kits (111) and many more products for this protein.

The ratios of IGF-I (show IGF1 Proteins)/IGFBP-3 were increased in postmenopausal Taiwanese women with breast cancer, irrespective of their ages, ER and PR statuses, and HER2 (show ERBB2 Proteins) expression.

Higher IGF-I (show IGF1 Proteins) levels among postmenopausal women and an elevated IGF-I:IGFBP-3 ratio among all women were associated with higher TDLU counts ; these associations were strongest among women with elevated mammographic density

IGFBP-3 is an aggravating factor during hepatic ischemia-repefusion injury.

An increase in IGFBP-3 post-trauma may play an important role in limiting trauma-induced inflammatory and apoptotic pathways leading to retinal damage.

Even though knockout of IGFBP-3 is associated with only a subtle phenotype under control conditions, our results reveal that loss of this gene has measurable effects on breast carcinogenesis and breast cancer metastasis.

Igfbp3 is a marker for culture-activated hepatic stellate cells and plays a role in HSC (show FUT1 Proteins) migration.

Igfbp2-5 are expressed in distinct and complementary patterns during cochlear development.

IGFBP-3 has novel protective effects on retinal and systemic vasculature and may be a therapeutic candidate for ocular complications such as diabetic retinopathy.

These data suggest that endogenous IGFBP-3 plays a role in intrinsic apoptosis by facilitating phosphorylation and nuclear export of Nur77 (show NR4A1 Proteins) to the cytoplasm where it exerts its apoptotic effect.

The present study suggests that the insulin (show INS Proteins) like growth factor (IGF) system or imbalances between IGF and IGF binding (show HTRA1 Proteins) proteins may be involved in cystic ovary disease of cattle.

spatial and temporal patterns of expression of IGFBP-2 and -3 were markedly altered in the placentomes of nuclear transfer pregnancies

stimulation of IGFBP-3 mRNA levels by mitogens is regulated through both the PI3K and MAPK (show MAPK1 Proteins) pathways in bovine mammary epithelial cells

Multivariable adjusted analyses did not reveal a statistically significant linear relationship between IGF1 (show IGF1 Proteins) or IGFBP3 concentrations or their molar ratio and risk of myocardial infarction

IGFBP3 Protein Profile

Protein Summary

This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.