The theme of the third annual Spring workshop of the HUPO-PSI was proteomics and beyond and its underlying goal was to reach beyond the boundaries of the proteomics community to interact with groups working on the similar issues of developing interchange standards and minimal reporting requirements. Significant developments in many of the HUPO-PSI XML interchange formats, minimal reporting requirements and accompanying controlled vocabularies were reported, with many of these now feeding into the broader efforts of the Functional Genomics Experiment data (...) model and Functional Genomics Ontology ontologies. (shrink)

In a world with at least three times as many nations as states, what are the limits of legitimate nation-building? How can national self-determination be coordinated within a federal system? This book provides one of the most extensive discussions to date on the ethics of nation-building and the nature and justification of federal systems.

Can war ever be justified? Why is it wrong to kill? In this new book Richard Norman looks at these and other related questions, and thereby examines the possibility and nature of rational moral argument. Practical examples, such as the Gulf War and the Falklands War, are used to show that, whilst moral philosophy can offer no easy answers, it is a worthwhile enterprise which sheds light on many pressing contemporary problems. A combination of lucid exposition and original argument (...) makes this the ideal introduction to both the particular debate about the ethics of killing and war, and also to the fundamental issues of moral philosophy itself. (shrink)

humanism /'hju:menizm/ n. an outlook or system of thought concerned with human rather than divine or supernatural matters. Albert Einstein, Isaac Asimov, E.M. Forster, Bertrand Russell, and Gloria Steinem all declared themselves humanists. What is humanism and why does it matter? Is there any doctrine every humanist must hold? If it rejects religion, what does it offer in its place? Have the twentieth century's crimes against humanity spelled the end for humanism? On Humanism is a timely and powerfully argued philosophical (...) defence of humanism. It is also an impassioned plea that we turn to ourselves, not religion, if we want to answer Socrates' age-old question: what is the best kind of life to lead? Although humanism has much in common with science, Richard Norman shows that it is far from a denial of the more mysterious, fragile side of being human. He deals with big questions such as the environment, Darwinism and 'creation science', euthanasia and abortion, and then argues that it is ultimately through the human capacity for art, literature and the imagination that humanism is a powerful alternative to religious belief. Drawing on a varied range of examples from Aristotle to Primo Levi and the novels of Virginia Woolf and Graham Swift, On Humanism is a lucid and much needed reflection on this much talked about but little understood phenomenon. (shrink)

The concepts of freedom and equality lie at the heart of much contemporary political debate. But how, exactly, are these concepts to be understood? And do they really represent desirable political values? Norman begins from the premise that freedom and equality are rooted in human experience, and thus have a real and objective content. He then argues that the attempt to clarify these concepts is therefore not just a matter of idle philosophical speculation, but also a matter of practical (...) politics, for the philosophical conclusions we reach also have important implications for the day-to-day world of political action. Touching on the work of such influential thinkers as Mill, Berlin, Hayek, Nozick, Rawls, and Williams, this book serves as a valuable introduction to the central issues in political philosophy. (shrink)

Paton, Margaret It was the unfamiliar word dewfall that kept my attention and the relation of dewfall to God's Spirit. It will fall on the bread and wine like dew falling. What is it that connects God's Spirit with dew falling that makes it so memorable for me? It is because in the midst of Mass dewfall is a symbol of the powerful outpouring of God's love for Christ crucified and for me, as I praise Him for His goodness. (...) There is also the sheer beauty of dew when it is first seen in the morning that can overwhelm me with its pristine freshness and purity of shimmering brightness with not a mark of a footprint on it. Dew can freshen our spirits, making them receptive. However, the question remains, What does dew have to do with the Spirit of God? What is the likeness between dewfall and the Spirit of God? (shrink)

This article surveys recent work on the idea of "citizenship", not as a legal category, but as a normative ideal of membership and participation. We focus on two emerging issues. First, whereas traditional notions of citizenship assume that membership and participation are promoted by the possession of rights, many theorists now emphasize civic responsibilities. Second, whereas traditional theories assume that citizenship provides a common status and identity, some theorists now argue that the distinctive needs and identities of certain groups -such (...) as women, ethnic minorities, the disabled - can only be accommodated through "group-differentiated citizenship". The writings of neo-conservatives, participatory democrats, civic republicans, feminists, civil society theorists, virtue theorists and cultural pluralists are surveyed. (shrink)

This paper raises a challenge for those who assume that corporate social responsibility and good corporate governance naturally go hand-in-hand. The recent spate of corporate scandals in the United States and elsewhere has dramatized, once again, the severity of the agency problems that may arise between managers and shareholders. These scandals remind us that even if we adopt an extremely narrow concept of managerial responsibility – such that we recognize no social responsibility beyond the obligation to maximize shareholder value – (...) there may still be very serious difficulties associated with the effective institutionalization of this obligation. It also suggests that if we broaden managerial responsibility, in order to include extensive responsibilities to various other stakeholder groups, we may seriously exacerbate these agency problems, making it even more difficult to impose effective discipline upon managers. Hence, our central question: is a strong commitment to corporate social responsibility institutionally feasible? In searching for an answer, we revisit the history of public management, and in particular, the experience of social-democratic governments during the 1960s and 1970s, and their attempts to impose social responsibility upon the managers of nationalized industries. The results of this inquiry are less than encouraging for proponents of corporate social responsibility. In fact, the history of public-sector management presents a number of stark warnings, which we would do well to heed if we wish to reconcile robust social responsibility with effective corporate governance. (shrink)

This paper looks at conflicts of interest in the not-for-profit sector. It examines the nature of conflicts of interest and why they are of ethical concern, and then focuses on the way not-for-profit organisations are especially prone to and vulnerable to conflict-of-interest scandals. Conflicts of interest corrode trust; and stakeholder trust (particularly from donors) is the lifeblood of most charities. We focus on some specific challenges faced by charitable organisations providing funding for scientific (usually medical) research, and examine a case (...) study involving such an organisation. One of the principal problems for charities of this kind is that they often distribute their funds within a relatively small research community (defined by the boundaries of a small region, like an American state or Spanish Autonomous region, or a small country), and it often proves difficult to find high-level researchers within the jurisdiction to adjudicate impartially the research grants. We suggest and recommend options appropriate for our case study and for many other organisations in similar situations. (shrink)

The conception of social justice as equality is defended in this paper by examining what may appear to be two inegalitarian conceptions of justice, as distribution according to desert and as distribution according to need. It is argued that claims of just entitlement arise within a context of reciprocal co-operation for mutual benefit. Within such a context there are special cases where it can be said that those who contribute more deserve more, and that those who need more should get (...) more, but those claims themselves presuppose a norm of equal contribution and equal benefit. (shrink)

I want to consider the suggestion that certain essential components of human experience are by their nature distinctively religious, and thus that the atheist is either debarred from participating fully in such experiences, or fails to understand their real nature. I am going to look at five kinds of experience: • the experience of the moral 'ought'; • the experience of beauty; • the experience of meaning conferred by stories; • the experience of otherness and transcendence; • the experience of (...) vulnerability and fragility. These seem to me to be integral features of any meaningful human life. They are aspects of what it is to be human. Some theists would simply agree with that statement. Others, however, would say that though essentially human they are also essentially religious, and that the secular humanist's participation in such experiences is in some way defective. That is the claim which I want to consider and contest. (shrink)

This paper attempts to defend the value of equality against the accusation that it is an expression of irrational and disreputable feelings of envy of those who are better off. It draws on Rawls’ account of the sense of justice to suggest that resentment of inequalities may be a proper resentment of injustice. The case of resentment of ‘free riders’ is taken as one plausible example of a justified resentment of those who benefit unfairly from a scheme of cooperation. Further (...) examples then link the case of the free rider to other cases of unjust inequalities which are the appropriate objects of resentment and indignation. (shrink)

Jonathan Dancy, in his 1994 Aristotelian Society Presidential Address, set out to show ''why there is really no such thing as the theory of motivation''. In this paper I want to agree that there is no such thing, and to offer reasons of a different kind for that conclusion. I shall suggest that the so-called theory of motivation misconstrues the question which it purports to answer, and that when we properly analyse the question and distinguish it clearly from other questions (...) with which it should not be confused, we do not need a theory of motivation at all. (shrink)

We first describe how the concept of “fringe consciousness” can characterise gradations of consciousness between the extremes of implicit and explicit learning. We then show that the NEO-PI-R personality measure of openness to feelings, chosen to reflect the ability to introspect on fringe feelings, influences both learning and awareness in the serial reaction time task under conditions that have previously been associated with implicit learning . This provides empirical evidence for the proposed phenomenology and functional role of fringe consciousness in (...) so-called implicit learning paradigms . Introducing an individual difference variable also helped to identify possible limitations of the exclusion task as a measure of conscious sequence knowledge. Further exploration of individual differences in fringe awareness may help to avoid polarity in the implicit learning debate, and to resolve apparent inconsistencies between previous SRT studies. (shrink)

Metaphor influences the construction of biological models and theories and the analysis of its use can reveal important tools of thought. Some aspects of biological organisation are investigated through the analysis of metaphors associated with treating biosystems as a kind of text. In particular, the use of glue and verbs is considered. Some of the reasons why glue is important in the construction of hierarchies are pursued in the light of specific examples, and some of the conceptual links between glue (...) in biology and other domains is discussed. Verbs are shown to be important in the construction of networks. Some of the relations between glue, verb and text are considered and the text metaphor is placed within a much broader context of ideas associated with form, relation and system. The paper concludes with comments on the nature of biological information and the need for extending or better understanding the verbal vocabulary. (shrink)

The purpose of this study is twofold. The first objective is to examine the impact of an individual's ethical ideology and level of professional commitment on the earnings management decision. The second objective is to observe whether the presence of a personal benefit affects an individual's ethical orientation or professional commitment within the context of an opportunity to manage earnings. Using a sample of 375 undergraduate business majors, our results suggest a significant relationship between an individual's ethical orientation and decision-making. (...) Further, participants with higher levels of professional commitment seem to be less likely to engage in earnings management behavior and less likely to behave opportunistically. These results have the potential to add to our understanding of certain behaviors in entry-level personnel and should be of interest to managers, practitioners, academicians, and researchers. (shrink)

The metaphorical nature of biological language is examined and the use of metaphors for providing the linguistic context in which similarities and differences are made is described. Certain pervasive metaphors which are characterised by systemic properties are noted, and in order to provide some focus to the study, systemic metaphors associated with machine, text and organism are discussed. Other systemic metaphors such as society and circuit are also reported. Some details concerning interrelations between automaton and organism are presented in the (...) light of the previous discussion.An approach towards the analysis of biosystem metaphors is outlined which relates part-whole, organisational level and systemic metaphors in a single model. Examples are provided throughout the discussion and mainly come from computing. The potential for metaphorical transfers between these domains is considered. (shrink)

Nietzsche sees base morality and traditional philosophy as reactive, essentially predicated on negation and opposition. But is it possible to reject negation? To oppose oppositionality? This issue has been addressed by a variety of 20th century thinkers who think that the paradox is insurmountable. I use the thought of Deleuze to propose a way Nietzsche can respond to the accusation of paradox. Specifically, I believe Nietzsche proposes a set of philosophical terms that allow him to refer the question of opposition (...) to a critical analysis of types of wills. Nietzsche attempts to show us a will that does not negate and oppose, but is rather affirmative. Its affirmation will be creative, rather than recognizing and reacting to an antecedent state of affairs or set of values. The purpose of this paper is to argue for the coherence and novelty of this conception of affirmative, noble will. (shrink)

We discuss five kinds of representations of rationales and provide a formal account of how they can alter disputation. The formal model of disputation is derived from recent work in argument. The five kinds of rationales are compilation rationales, which can be represented without assuming domain-knowledge (such as utilities) beyond that normally required for argument. The principal thesis is that such rationales can be analyzed in a framework of argument not too different from what AI already has. The result is (...) a formal understanding of rationales, a partial taxonomy, and a foundation for computer programs that represent and reason with rationales.The five kinds of rationales are as follows: (c)ompression and (s)pecialization, which yield rules, and (d)isputation, which yields a decision. These are modeled as potentially changing the focus of the dispute. Then there are (f)it, a rationale for rules, and (r)esolution, a rationale for decisions. These cannot be modeled as simply; they force disputation to a meta-level, at least temporarily. (shrink)