The oncogenic isoform of HER2, HER2Î”16, is expressed with HER2 in nearly 50% of HER2 positive breast tumors where HER2Î”16 drives metastasis and resistance to multiple therapeutic interventions including tamoxifen and trastuzumab. The research...

MicroRNAs (miRNAs) are small non-coding 18-22 long RNAs, which act as key mediators in many cellular processes involved in tumorigenesis including proliferation, differentiation, invasion, and apoptosis. miRNAs repress gene expression by inhibiting...

MiR-17-92 is an oncogenic miRNA cluster implicated in the development of several human cancers; however, it remains unknown whether miR-17-92 cluster is able to regulate hepatobiliary carcinogenesis. This study was designed to investigate the...

Triple-negative breast cancer (TNBC) accounts for 15% of all diagnosed breast cancers nationally and affects African-American women 3 times more likely than any other ethnic group. Locally, African-American women in the New Orleans area see higher...

MicroRNAs (miRNAs) are a group of small, noncoding RNAs that modulate the translation of genes into proteins by binding to specific target sites in messenger RNAs. This study investigated the biological function and molecular mechanism of...

High oncogenic risk types of human papillomavirus (HPV) are associated with cervical epithelial abnormalities and cancer of the uterine cervix. Individuals infected with the human immunodeficiency virus (HIV) are at increased risk of acquiring HPV,...

The Missouri Poultry Cohort is a historical cohort investigation of mortality among workers highly exposed to the poultry oncogenic viruses which are suspected cancer causing agents in humans. Workers were also exposed to fumes from PVC-wrapping...

Next generation sequencing (NGS) is a relatively new technology that has revolutionized the way scientists discover and investigate pathogens. It has been estimated that a staggering one in every five cancers worldwide is linked to an infectious...