Exploradio Origins: The Birth of Cancer Immunotherapy

An oral squamous cancer cell (white) being attacked by two cytotoxic T cells (red), part of a natural immune response.

NATIONAL CANCER INSTITUTE

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The body's own immune system is being used to treat cancer.

Each time our cells grow and divide, they have to perfectly copy out almost a billion elements of genetic code. Of course, perfect almost never happens. So as soon as there was a genetic code, life had to evolve a way to fix DNA mismatches. But sometimes people inherit mutations in those DNA mismatch repair genes, and then you have really challenging cancers. But, at the bottom of this, there lies some hope in our own immune systems.

Gerson discovered that the broken mismatch repair system making the cancer cells with a ton of mutations in them is actually the key to training our immune system to recognizing and killing the cancer.

“Our newest chemotherapies are immune treatments that recognize abnormal cells based on abnormal proteins which result from the abnormal mutations that occurred because of the mismatch repair loss. Over 90 percent of patients with this horrible mutation that they inherit and develop cancer can be cured, which is absolutely remarkable.”