Shandling will be remembered for many prominent roles and appearances in the entertainment business, most notably The Larry Sanders Show on HBO, which he starred in and co-created. For his role in the show, which hilariously took place in the office of a fictional late-night talk show, Shandling would be nominated for a whipping 18 Emmy awards.

In addition to his HBO dominance, Shandlers hosted several prominent awards ceremonies, including the GRAMMYs three times, and the Emmys twice. He was also a known voiceover talent, contributing voices to blockbuster films like Iron Man 2, Captain America: The Winter Soldier and Over The Hedge. He was at one point sought after by NBC to be David Letterman‘s successor as the host of Late Night, but opted instead to push forward with The Larry Sanders Show, which proved to be a fortuitous decision.