Base deal of $125 million in gross proceeds from specified categories of specialized investors closed on November 14, 2017 . Announced full exercise of underwriters’ option to purchase additional American Depositary Shares (ADSs) and Ordinary Shares, with closing expected to take place on or about

Base deal of $125 million in gross proceeds from specified categories of specialized investors closed on November 14, 2017 . Announced full exercise of underwriters’ option to purchase additional American Depositary Shares (ADSs) and Ordinary Shares, with closing expected to take place on or about