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The event hits particularly close to home for Brad/Pearl Jam guitarist Stone Gossard, whose wife's mother, brother and grandfather have suffered with Huntington's. Woody Guthrie is the most prominent name associated with the disease, a rare neurological disorder that is somewhat akin to Parkinson's disease or multiple sclerosis.

There is no cure for Huntington's, but symptoms can be managed with medication.

"There are so many people in the HD community that don't have the care they need," Gossard told www.Billboard.com. "We wanted to support both the care that people get for HD through local chapters and any scientific breakthroughs that may be on the horizon."

While in New York, Brad will play a separate headlining show on Oct. 16 at the Highline Ballroom.

Gossard has also finished tweaking a batch of material the band recorded in 2004 but is just now ready to release, comprising the songs "Every Whisper," "Rush Hour," "No Regrets," "Price of Love," "One Love Remains," "Low," "Bless Me Father," "Believe in Yourself," "Oh Goodness," "Luxury Car" and "Holiday."

In addition, the band has acquired the rights to its first two albums for Epic, plus albums from connected groups such as Satchel and Malkfunksun, and is hoping to reissue the projects at some point in the future. "We're trying to figure out how to play a little bit more often," Gossard says. "We want to keep the band alive."