Theophylline appears to impair the normal conversion of vitamin B
6
into the more active substance pyridoxal 5'-phosphate (PLP).
1–4
These findings have led some researchers to suspect that some of the many side effects of theophylline could be caused, at least in part, by interference with B
6
activity. Indeed, one study found that B
6
supplements might help reduce theophylline-induced tremors.
5

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