ProHeart 12 is here year-round to protect your dog

ProHeart 12 fits in with annual wellness visits

With no monthly doses to remember, there are no gaps in protection for a full year. It’s so important to keep your dog protected. Just one missed dose of any heartworm preventative can result in heartworm disease, a potentially fatal condition.

Just one shot of ProHeart 12 provides protection for your dog all year long.

Earn rewards while protecting your dog from heartworm disease

Frequently asked questions

Find answers to common questions about ProHeart products

What is ProHeart&nbsp;12?

ProHeart 12 is the only FDA-approved product that prevents heartworm disease in dogs for 1 full year with just 1 shot given by your veterinarian. At the time of the shot, ProHeart 12 also treats hookworms.* ProHeart 12 is for use in healthy dogs 12 months of age and older.

*ProHeart 12 is indicated for the treatment of existing larval and adult hookworm (Ancylostoma caninum and Uncinaria stenocephala) infections.

How much does ProHeart&nbsp;12 typically cost?

On average, the price of a ProHeart 12 shot is about the same as 12 months’ worth of a monthly heartworm disease preventative. Cost may vary depending on how much your dog weighs. Ask your veterinarian for details.

Is ProHeart&nbsp;12 right for my dog?

ProHeart 12 can be used in healthy dogs 12 months of age and older. Talk with your veterinarian about ProHeart 12 for your dog.

Is ProHeart&nbsp;12 safe?

Yes. In fact, in a clinical study with client-owned dogs, ProHeart 12 had a similar adverse event profile to Heartgard Plus. The most common side effects were vomiting, diarrhea, and lethargy.

How does ProHeart&nbsp;12 work?

ProHeart 12 provides 1 full year of heartworm disease prevention in just 1 shot. The active ingredient, moxidectin, is contained in slow-dissolving microspheres that are stored in your dog’s fat-storing connective tissue (a.k.a. adipose tissue). The medicine is then released evenly over 1 year’s time, keeping your buddy consistently protected from heartworms. Cool, right?

What is heartworm disease?

Heartworm disease is serious and potentially fatal—and a single bite from an infected mosquito can cause it in your dog. See the basics about heartworm disease, including your dog’s risk and some of the signs and symptoms.

Is ProHeart&nbsp;12 a vaccine?

No, ProHeart 12 is not a vaccine because it does not stimulate the production of antibodies. ProHeart 12 is an injection of preventative medicine that slowly releases over time in your dog’s body.

What’s the difference between ProHeart&nbsp;6 and ProHeart&nbsp;12?

ProHeart 6 provides 6 months of heartworm disease prevention for dogs and ProHeart 12 provides 1 full year of heartworm disease prevention for dogs. Dogs older than 6 months but less than 1 year old should be given ProHeart 6.

Does my dog need a heartworm test before starting ProHeart&nbsp;12?

It’s important to know if your dog has heartworms before starting a new heartworm product or switching to a different one. Not sure when your dog last had a heartworm test? Check with your veterinarian before giving any heartworm medication—not just when starting a new product or switching.

What if my dog tests positive for heartworms before taking ProHeart&nbsp;12?

Of course we all hope that won’t happen! But if it does, your veterinarian will want to start by running a different test to confirm the diagnosis. If that test also shows a positive result, your veterinarian will talk with you about a treatment plan.

How do I switch from another heartworm disease preventative to ProHeart&nbsp;12?

Important Safety Information: Use PROHEART 6 in dogs 6 months of age or older and PROHEART 12 in dogs 12 months of age or older. Do not administer to dogs that are sick, debilitated, underweight, have a history of weight loss, or to those previously found to be hypersensitive to the drug. Hypersensitivity reactions may occur in some dogs when PROHEART is administered alone or with vaccines. Anaphylactic and anaphylactoid reactions can result in death and should be treated immediately with the same measures used to treat hypersensitivity reactions to vaccines and other injectable products. Reported side effects in clinical trials included vomiting, lethargy, diarrhea, anorexia, and hypersensitivity reactions. People should avoid inhalation, contact with eyes, or accidental self-injection. Certification is required before veterinarians and staff administer these products. See full Prescribing Information for ProHeart 6 and ProHeart 12.

The product information provided in this site is intended only for residents of the United States. The products discussed herein may not have marketing authorization or may have different product labeling in different countries. The animal health information contained herein is provided for educational purposes only and is not intended to replace discussions with an animal healthcare professional. All decisions regarding the care of a veterinary patient must be made with an animal healthcare professional, considering the unique characteristics of the patient.