Thus Spoke Sardathustra
@Sol
Remember the wise words of Garland the Horrifically Incompetent:
"As villains, it's our job to haughtily assume our plucky rivals were soundly defeated by mundane means without anyone to witness their demise. Also, it doesn't matter how easily we are thwarted in our varied and constant attempts on their lives. Their apparent death proves we would have beaten them eventually anyway."

Well, unfortunately the only real way to make sure a hero from their association dies for good is dismemberment and thoroughly destroying the dismembered pieces.
More or less cut to pieces, put through a meat grinder then dissolved in acid, then dump that acid into a void or a volcano or something.

For less organic foes the process is similar but instead of a meat grinder you're going to have to more or less "nuke" the pieces. depending on what they're made of. Ashes and slag should be the universal death to all things.

@Hydra: Now that the holiday season is upon us once more, the seasonal barrage of fruitcake pics and goofs has returned to haunt me once more. God help me, I can now tell different brands and types of fruitcake apart. I have made for myself my own hell.

Really, much simpler.
@Xylas_Incarnum
You can just vaporize their very essence, then tear the entire laboratory off the face of the structure it is on, then annihlate the laboratory and funnel the annihlated area into a black hole. From there, demolish the entire planet that they came from, along with the planet the laboratory is on. This gives a 4.2%-29% chance of success. Throwing in a Helldoken or three helps.

huh...
@Alexis_Royce: so... regarding what you said above to sol. Sire takes place in the evil plan universe or vice versa right? that means the binding is an actual force of... i am hesitant to say nature but for lack of a better term i'll say nature.

Back on topic. Comic books are a form of literature, regardless what people think. Could the binding have latched onto kinnie and kevin? Like it would explain how they got to kevin in time to save him and put him into crippling super hero debt as a member of the company to market his ass til hes so dead they cant do so any more. also explains kinnies tragic backstory and the loss of his friend in such a hilarious if sad way.

I guess what I am asking is: is the binding an actual force in the evil plan universe?

@wilddeath: Things ended up becoming a little complicated there, so I'll update the record on this:
Sire, Evil Plan (and morphE) all take place in parallel universes. The Binding is strongest in the Sire universe. Evil Plan's the universe where superheroes became a public thing.

The Binding kinda exists in the Evil Plan universe, but it's not something that I'm ever going to bring up in the comic itself. And it's not strong enough to make Lineage Children. It could've had a hand in everyone's backstories, so I think it's not a bad headcanon!