Words similar to diploidy

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diploidy

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Cdk-1 is believed to regulate the G2 checkpoint of the cell cycle and is required to maintain diploidy.

Since S. pombe contains only three chromosome pairs, aberrant assortment during one or both of the meiotic divisions can produce, by chance, a significant fraction of meiotic products that receive at least one copy of each chromosome and are hence viable [ 38 43 ] . Aberrant segregation can also produce nullisomic aneuploids (missing one or more chromosomes), polysomic aneuploids (having additional copies of individual chromosomes), and diploids [ 38 39 44 ] . In S. pombe the haploids and diploids are viable, nullisomic aneuploids are inviable, and disomic aneuploids tend to lose the extra chromosome or chromosomes and become haploid [ 45 ] . We therefore determined the frequencies of spore viability and meiotic diploidy as genetic measures of chromosome segregation errors.

Mating, meiosis, and preparation of free spores were as described [ 54 55 65 ] . Intergenic and intragenic recombinant frequencies were determined as described [ 38 65 ] . Because diploid spores could contain complementing markers and be mistaken for recombinants, we tested all spore colonies for diploidy by replica plating on complete media containing Phloxin-B (YEA-B).