Fusion

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Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:query proteins and first shell of interactors

white nodes:second shell of interactors

Node Content

empty nodes:proteins of unknown 3D structure

filled nodes:some 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

NBP35

Predicted protein; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. Functions as Fe-S scaffold, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Essential for embryo development (360 aa)

Predicted Functional Partners:

PP1S240_88V6.1

Annotation not available (467 aa)

0.971

PP1S30_228V6.1

Predicted protein (289 aa)

0.927

PP1S21_387V6.1

Predicted protein (373 aa)

0.927

PP1S107_189V6.1

Predicted protein (811 aa)

0.898

PP1S83_234V6.1

Uridine kinase (530 aa)

0.762

PP1S488_8V6.1

Uridine kinase (520 aa)

0.762

PP1S370_24V6.1

Uridine kinase (486 aa)

0.762

PP1S19_94V6.1

Predicted protein (482 aa)

0.762

PP1S89_265V6.1

NADPH-dependent FMN and FAD-containing oxidoreductase ; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis. Transfers electrons from NADPH to the Fe-S cluster of the anamorsin/DRE2 homolog (653 aa)

a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1

node2

node1 accession

node2 accession

node1 annotation

node2 annotation

score

NBP35

PP1S107_189V6.1

PP1S61_191V6.1

PP1S107_189V6.1

Predicted protein; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. Functions as Fe-S scaffold, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Essential for embryo development

Predicted protein

0.898

NBP35

PP1S19_94V6.1

PP1S61_191V6.1

PP1S19_94V6.1

Predicted protein; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. Functions as Fe-S scaffold, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Essential for embryo development

Predicted protein

0.762

NBP35

PP1S21_387V6.1

PP1S61_191V6.1

PP1S21_387V6.1

Predicted protein; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. Functions as Fe-S scaffold, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Essential for embryo development

Predicted protein

0.927

NBP35

PP1S240_88V6.1

PP1S61_191V6.1

PP1S240_88V6.1

Predicted protein; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. Functions as Fe-S scaffold, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Essential for embryo development

Annotation not available

0.971

NBP35

PP1S30_228V6.1

PP1S61_191V6.1

PP1S30_228V6.1

Predicted protein; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. Functions as Fe-S scaffold, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Essential for embryo development

Predicted protein

0.927

NBP35

PP1S370_24V6.1

PP1S61_191V6.1

PP1S370_24V6.1

Predicted protein; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. Functions as Fe-S scaffold, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Essential for embryo development

Uridine kinase

0.762

NBP35

PP1S488_8V6.1

PP1S61_191V6.1

PP1S488_8V6.1

Predicted protein; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. Functions as Fe-S scaffold, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Essential for embryo development

Uridine kinase

0.762

NBP35

PP1S52_243V6.1

PP1S61_191V6.1

PP1S52_243V6.1

Predicted protein; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. Functions as Fe-S scaffold, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Essential for embryo development

Anamorsin homolog 1

0.739

NBP35

PP1S83_234V6.1

PP1S61_191V6.1

PP1S83_234V6.1

Predicted protein; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. Functions as Fe-S scaffold, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Essential for embryo development

Uridine kinase

0.762

NBP35

PP1S89_265V6.1

PP1S61_191V6.1

PP1S89_265V6.1

Predicted protein; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. Functions as Fe-S scaffold, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Essential for embryo development

NADPH-dependent FMN and FAD-containing oxidoreductase ; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis. Transfers electrons from NADPH to the Fe-S cluster of the anamorsin/DRE2 homolog

0.744

PP1S107_189V6.1

NBP35

PP1S107_189V6.1

PP1S61_191V6.1

Predicted protein

Predicted protein; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. Functions as Fe-S scaffold, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Essential for embryo development

0.898

PP1S107_189V6.1

PP1S19_94V6.1

PP1S107_189V6.1

PP1S19_94V6.1

Predicted protein

Predicted protein

0.756

PP1S107_189V6.1

PP1S21_387V6.1

PP1S107_189V6.1

PP1S21_387V6.1

Predicted protein

Predicted protein

0.436

PP1S107_189V6.1

PP1S30_228V6.1

PP1S107_189V6.1

PP1S30_228V6.1

Predicted protein

Predicted protein

0.436

PP1S107_189V6.1

PP1S370_24V6.1

PP1S107_189V6.1

PP1S370_24V6.1

Predicted protein

Uridine kinase

0.756

PP1S107_189V6.1

PP1S488_8V6.1

PP1S107_189V6.1

PP1S488_8V6.1

Predicted protein

Uridine kinase

0.756

PP1S107_189V6.1

PP1S52_243V6.1

PP1S107_189V6.1

PP1S52_243V6.1

Predicted protein

Anamorsin homolog 1

0.925

PP1S107_189V6.1

PP1S83_234V6.1

PP1S107_189V6.1

PP1S83_234V6.1

Predicted protein

Uridine kinase

0.756

PP1S19_94V6.1

NBP35

PP1S19_94V6.1

PP1S61_191V6.1

Predicted protein

Predicted protein; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. Functions as Fe-S scaffold, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Essential for embryo development

0.762

PP1S19_94V6.1

PP1S107_189V6.1

PP1S19_94V6.1

PP1S107_189V6.1

Predicted protein

Predicted protein

0.756

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Network Stats

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Functional enrichments in your networkNote: some enrichments may be expected here (why?)

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Statistical background

For the above enrichment analysis, the following statistical background is assumed: