Does anyone know if there is currently a list anywhere that lists out games that either require or don't require LLE? Right now I've only been able to find out on specific game wiki pages or on forum posts. A list would be pretty helpful to have and easier, as if you can get away with using HLE you would be saving a decent amount of performance.

I actually haven't heard of any issues about Animal Crossing under HLE audio (though that doesn't mean they aren't there). It uses the "Light" version of the Zelda microcode. Though the Pikmin GC games use the "Light" version as well, and they have issues with cutscenes without LLE audio.

Don't the factor 5 games do weird thing, too? I know they meddle with a lot of things at a low level.

OS: Windows 10 64 bit Professional
CPU: Intel i5 4670K @3.4GHz... for now @4.6GHz with a quick and dirty (yet stable) OC. May get faster in a bit before the end of time.
RAM: 16GB (Down from 24 GB after some was given to siblings)
GPU: Radeon Vega 56