Palladium- and Nickel-Catalyzed Coupling Reactions

Palladium- and nickel-catalyzed cross-couplings and Heck reactions are widely used
in synthetic organic chemistry (e.g., in the total synthesis of taxol,
rapamycin, and dynemicin). We have developed catalysts that can achieve
couplings that were not previously possible. In addition, we have pursued
mechanistic studies that have provided insight into the reaction pathways.