His best known role was that of Det. Dave Starsky in American TV series Starsky and Hutch. The series is about two friends police, Dave Starsky and Ken Hutchinson; David Soul, to solve all kinds of cases. The series ran between 1975 and 1979. And they filmed 82 episodes. Glaser and Soul have a small role in the movie Starsky & Hutch (2004).

He was a guest star on the TV series: Cannon (1972), The Streets of San Francisco (1972), The Waltons (1973), Kojak (1974), The Closer (2008), Criminal Minds (2008), Numb3rs (2008), and The Mentalist (2009).