MMA fans prone to motion sickness are advised to take Dramamine on Saturday night, and journalists with play-by-play duties should rest their fingers for UFC on FOX 6’s main draw.

The flyweights are back, but that won’t be the only thing moving fast on Saturday night. Key matchups in the lightweight and featherweight divisions joined the event’s main card, and a light-heavyweight tilt offers a glimpse at the title worthiness of a longtime dark horse.

UFC on FOX 6 takes place at United Center in Chicago. Main-card fights air live on FOX following prelims on FX and Facebook.

UFC on FOX 6’s network competition that night includes the series premiere of cooking show “The Taste,” popular cop show “NCIS: Los Angeles” and the U.S. Figure Skating Championships.

This might be a stretch, but only one of those shows should give the UFC a run for its money in key male demographics. Instead, a trio of college basketball games on ESPN should provide a better measuring stick.

And, there’s a rerun of Stanley Kubrick’s “Full Metal Jacket” on Encore, but that’s just a personal note.

UFC on FOX 6 is the second consecutive FOX event to feature a title fight in its headliner. Flyweight champion Demetrious Johnson (16-2-1 MMA, 4-1-1 UFC) attempts his first title defense against challenger John Dodson (14-5 MMA, 3-0 UFC), and UFC on FOX 7 will see ex-Strikeforce champ Gilbert Melendez vie for a new belt against UFC lightweight champ Benson Henderson. It’s a good strategy for the UFC, which is able to tout the prestige of a title fight without sacrificing the pay-per-view dollars of marquee fighters in the heavier divisions.

Despite a bad run in his recent career, the aggrieved Quinton “Rampage” Jackson (32-10 MMA, 7-4 UFC) provides some of that luster as a former champ with a hit movie under his belt. In the final obligation of his current UFC contract, he fights the talented, yet unproven, standout in Brazilian fighter Glover Teixeira (19-2 MMA, 2-0 UFC).

Rounding out the main card, lightweight rivals Donald Cerrone (19-4 MMA, 6-1 UFC) and Anthony Pettis (15-2 MMA, 2-1 UFC) meet after more than a year of delay in a bout that could put Pettis at the front of the line for a title shot. And near-featherweight contender Erik Koch (13-1 MMA, 2-0 UFC) hopes to regain his momentum following a knee injury by stepping past the tough Ricardo Lamas (12-2 MMA, 3-0 UFC).

MAIN-CARD BOUTS

Demetrious Johnson vs. John Dodson: Getting past the fact that the bout is going to be as fast paced as anything we’ll see inside the octagon, champ Johnson and challenger Dodson seem like mirror images of each other. They’re incredibly nimble on their feet and mix up striking and grappling in unpredictable ways. While the sample size of their stats is far from equal, as Johnson has more fights under the Zuffa banner, key differences should be noted in his wrestling and striking defense. Johnson lands almost three times the number of takedowns as Dodson and avoids nearly twice the number of strikes. That could play a big factor for the champ if either fighter is unable to finish. Dodson may be a little bit more of a wild card in the way he moves, and he may have a slight edge in punching power, but he hasn’t met as accomplished an MMA grappler as Johnson, and he doesn’t have the same level of experience against top-tier opposition. It could be a close one, but Johnson’s slight status as favorite is justified.

Quinton Jackson vs. Glover Teixeira: For all the crowing that he’s done in advance of his allegedly final UFC fight, Jackson speaks loudest with his fists. He’s convinced Teixeira will take him down and hold on for a decision, but he seems to have discounted the Brazilian’s work against big puncher Fabio Maldonado. Teixeira may not stay on his feet if he gets tagged by one of Jackson’s big hooks, but he certainly won’t shy away from it early on, and maybe less given that “Rampage” has basically goaded him into standing. It’s an MMA fight, and it won’t be limited to one range if either fighter fails to land a telling blow early. Jackson has the grappling chops to keep Teixeira at bay, but there’s a question of whether he’s truly motivated to use them. It seems just the opposite. When he fought Dan Henderson so many years ago, he refused to be passive on the ground and beat a far superior technical wrestler. Now, his skills seem to have dulled for reasons that have as much to do with circumstances outside the cage as inside. It could be that Jackson is healthy and focused, and if that’s the case, he should prevail over Teixeira, whose best years may have passed while him fighting on the local circuit in Brazil. But we’ll only know after the cage door shuts.

Donald Cerrone vs. Anthony Pettis: On paper, this lightweight matchup has “Fight of the Year” written all over it. The popular lightweights, who have jawed in the press after Cerrone’s callout, are both technical strikers with great bottom games on the mat. Cerrone is the more aggressive of the two and will likely try to wear out Pettis with volume over power, but he’ll be subject to Pettis’ counter-striking, which has knocked out several opponents. Given that a title shot is likely on the line for Pettis, it stands to reason that he could play a safer game plan and put Cerrone on his back for a grinding decision. But Cerrone’s skill with triangle chokes makes that a danger, so this could be a highly technical kickboxing match.

Erik Koch vs. Ricardo Lamas: Koch had a title shot in the bag at UFC 153, but a knee injury forced him to take a step back. He gets a tough test in again proving his title worthiness when he meets Lamas, whose wrestling shut down creative striker Cub Swanson. Koch was successful in keeping grappling specialist Jonathan Brookins away from him in his most recent fight, but that was in September 2011, which makes ring rust a possible factor going into Saturday. Lamas, who enjoys a three-fight win streak, would make a big statement with a win over Koch. But his chin has been found by strikers such as Yuri Alcantara and Danny Castillo, and unless he can keep the fight on the mat, Koch will be looking for the big counter.

As the UFC 189 tour made its last stop in Dublin, featherweight champ Jose Aldo was met with a torrent of abuse from the Irish fans. It might have been unpleasant, but it might also have been just what he needed.