WRONG TECHNIQUE IN DRUG USAGE PROCESS Clinical Trials and Studies

Treatments might be new drugs or new combinations of drugs, new surgical procedures or devices, or new ways to use existing treatments. The goal of clinical trials is to determine if a new test or treatment works and is safe. Clinical trials can also look at other aspects of care, such as improving the quality of life for people with chronic illnesses. People participate in clinical trials for a variety of reasons. Healthy volunteers say they participate to help others and to contribute to moving science forward. Participants with an illness or disease also participate to help others, but also to possibly receive the newest treatment and to have the additional care and attention from the clinical trial staff.

Change from baseline in cannabis use at 10 weeks; Change in withdrawal symptoms from baseline at 10 weeks; Change from baseline in cannabis use at 14 weeks; Change in withdrawal symptoms from baseline at 14 weeks

Duration of mechanical ventilation following administration of the first dose of Clonidine or placebo; Incidence and duration in hours of delirium currently used; Time to pass first SBT following administration of the first dose of Clonidine or placebo; Mean incidence and duration of delirium

Compare the onset of sensory and motor block between the control group and the control group; Compare the duration of sensory and motor block between the control group and the control group; Compare the mean VAS scores at 24 hours post procecure to determine the effectiveness of perineural Clonidine on duration of postoperative analgesia; Compare the number of subjects taking postoperative opioids to determine the effect of perineural Clonidine versus placebo; Compare the subjects mean blood pressure effect of perineural Clonidine versus placebo; number of subjects in each group requiring sedation; Determine the effect of perineural Clonidine versus placebo on time to discharge; Determine the effect of perineural Clonidine versus placebo on postoperative time to first analgesic intake; Compare the mean VAS scores at 24 hours post procedure to determine the patient satisfaction of perineural Clonidine on duration of postoperative analgesia

Postoperative Pain using a Verbal Rating Scale (VRS); Opioid consumption obtained from the recorded data; postoperative nausea and vomiting using a Verbal Rating Scale; return to normal activities of daily living using follow up questionnaires; Patient satisfaction using a verbal rating scale from 0 to 100

Percentage of patients with an oral mucositis score≥ 3 using the WHO scale at cumulative radiation dose of 50 Gy; Percentage of patients with an oral mucositis score≥ 3 using the WHO scale at cumulative radiation doses of 40 Gy and 60 Gy

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