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Spatial statistics in bioimage analysis

Thibault Lagache

Columbia University

Location

University of Pennsylvania

318 Carolyn Lynch Lab

New advances in fluorescence microscopy make possible the localization of thousands of molecules with nanometer resolution inside living cells. This calls for the development of new statistical tools in spatial analysis to characterize molecules' distribution, and the spatial coupling between different molecules in multi-color microscopy. We will present the tools that we have recently developed. These are based on the mathematical analysis of the Ripley’s K function, and allow to test statistically the randomness of molecules’ distribution inside individual cells, and also to measure the coupling between different molecules labeled in different colors. We will show some of the main biological applications of our tools.

How to get to Penn's Mathematics Department

The Mathematics Department Office is located on the fourth (top) floor of David Rittenhouse Laboratory ("DRL"). The building is at 209 South 33rd Street (the Southeast corner of 33rd. and Walnut Streets). Note 33rd Street runs one way northwhile Walnut runs one waywest.

We are about a 15 minute walk from the main 30th Street Station and 5 minutes from the University City Rail Station at 32nd and Spruce (=South Street & Convention Avenue). Coming from the airport by train (about 15 minutes): the University City Rail Station is the second stop after you leave the airport.

If you drive, the most convenient public parking is in the pay lot whose entrance is on 34th Street between Market and Chestnut Streets.