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Discovery of a 'conductor' in muscle developmentA team led by Jean-François Côté, researcher at the IRCM, identified a ''conductor'' in the development of muscle tissue. The discovery, published online yesterday by the scientific journal Proceedings of the National Academy of Sciences could have an important impact on the treatment of muscular diseases such as myopathies and muscular dystrophies.http://medicalxpress.com/news/2014-02-discovery-conductor-muscle.html
Medical researchTue, 25 Feb 2014 13:40:02 ESTnews312554828Researchers discover new path to address genetic muscular diseases(Medical Xpress)—For decades, scientists have searched for treatments for myopathies – genetic muscular diseases such as muscular dystrophy and ALS, also called Lou Gehrig's disease. Now, an interdisciplinary team of researchers from ASU, Stanford and University of Arizona has discovered a new avenue to search for treatment possibilities.http://medicalxpress.com/news/2013-11-path-genetic-muscular-diseases.html
Medical researchMon, 04 Nov 2013 05:22:09 ESTnews302764900Cancer wasting due in part to tumor factors that block muscle repair, study showsA new study reveals that tumors release factors into the bloodstream that inhibit the repair of damaged muscle fibers, and that this contributes to muscle loss during cancer wasting. The condition, also called cancer cachexia, accompanies certain types of cancer, causes life-threatening loss of body weight and lean muscle mass, and is responsible for up to one-in-four cancer deaths. There is no treatment for the condition.http://medicalxpress.com/news/2013-10-cancer-due-tumor-factors-block.html
CancerWed, 23 Oct 2013 16:10:01 ESTnews301761847Genotype influences muscle performanceElite endurance athletes commonly have mutations that result in the loss of the protein α-actinin-3, which is a major component of fast-twitch muscle fibers. Loss of α-actinin-3 is associated with reduced power, increased endurance capacity, and enhanced response to endurance training.http://medicalxpress.com/news/2013-09-genotype-muscle.html
Medical researchMon, 16 Sep 2013 12:00:02 ESTnews298537953New drug improves walking performance for Duchenne muscular dystrophy patientsResults from a clinical trial of eteplirsen, a drug designed to treat Duchenne muscular dystrophy, suggest that the therapy allows participants to walk farther than people treated with placebo and dramatically increases production of a protein vital to muscle growth and health. The study, led by a team in The Research Institute at Nationwide Children's Hospital, is the first of its kind to show these results from an exon-skipping drug—a class of therapeutics that allows cells to skip over missing parts of the gene and produce protein naturally.http://medicalxpress.com/news/2013-08-drug-duchenne-muscular-dystrophy-patients.html
NeuroscienceThu, 08 Aug 2013 02:28:22 ESTnews295147687Aberrant splicing saps the strength of 'slow' muscle fibersWhen you sprint, the "fast" muscle fibers give you that winning kick. In a marathon or just day-to-day activity, however, the "slow," or type 1 fibers, keep you going for hours.http://medicalxpress.com/news/2013-07-aberrant-splicing-saps-strength-muscle.html
Medical researchMon, 29 Jul 2013 15:00:24 ESTnews294324306Genetic editing shows promise in Duchenne muscular dystrophyUsing a novel genetic 'editing' technique, Duke University biomedical engineers have been able to repair a defect responsible for one of the most common inherited disorders, Duchenne muscular dystrophy, in cell samples from Duchenne patients.http://medicalxpress.com/news/2013-06-genetic-duchenne-muscular-dystrophy.html
GeneticsTue, 04 Jun 2013 16:14:49 ESTnews289581282Researchers find dying cells essential to muscle development and repairDying cells play an unexpected and vital role in the creation of muscle fibers, researchers at the University of Virginia School of Medicine have determined. The finding could lead to new ways to battle conditions such as muscular dystrophy, facilitate healing after surgery and benefit athletes in their efforts to recover more quickly.http://medicalxpress.com/news/2013-05-dying-cells-essential-muscle.html
Medical researchThu, 30 May 2013 06:27:59 ESTnews289114070Firefly protein lights up degenerating muscles, aiding muscular-dystrophy researchStanford University School of Medicine scientists have created a mouse model of muscular dystrophy in which degenerating muscle tissue gives off visible light. The observed luminescence occurs only in damaged muscle tissue and in direct proportion to cumulative damage sustained in that tissue, permitting precise monitoring of the disease's progress in the mice, the researchers say.http://medicalxpress.com/news/2013-04-firefly-protein-degenerating-muscles-aiding.html
Medical researchWed, 24 Apr 2013 12:00:02 ESTnews286022685Muscle repair after injury helped by fat-forming cells(Medical Xpress)—UC San Francisco scientists have discovered that muscle repair requires the action of two types of cells better known for causing inflammation and forming fat.http://medicalxpress.com/news/2013-04-muscle-injury-fat-forming-cells.html
Medical researchFri, 19 Apr 2013 07:38:10 ESTnews285575823Experimental gene therapy treatment for Duchenne muscular dystrophy offers hope for youngsterJacob Rutt is a bright 11-year-old who likes to draw detailed maps in his spare time. But the budding geographer has a hard time with physical skills most children take for granted—running and climbing trees are beyond him, and even walking can be difficult. He was diagnosed with a form of muscular dystrophy known as Duchenne when he was two years old.http://medicalxpress.com/news/2013-02-experimental-gene-therapy-treatment-duchenne.html
GeneticsThu, 07 Feb 2013 16:49:32 ESTnews279478154New design guidelines simplify development of targeted therapies for muscular dystrophy and other diseasesThe dystrophin protein offers critical support to muscle fibers. Mutations affecting dystrophin's expression cause the muscle-wasting disease muscular dystrophy. In Duchenne muscular dystrophy (DMD), these mutations take the form of small sequence changes that make much of the dystrophin gene (DMD) untranslatable, yielding nonfunctional protein or no protein at all.http://medicalxpress.com/news/2013-01-guidelines-therapies-muscular-dystrophy-diseases.html
GeneticsWed, 30 Jan 2013 07:00:01 ESTnews278749682Tamoxifen ameliorates symptoms of Duchenne muscular dystrophyA new study has found that tamoxifen, a well-known breast cancer drug, can counteract some pathologic features in a mouse model of Duchenne muscular dystrophy (DMD). At present, no treatment is known to produce long-term improvement of the symptoms in boys with DMD, a debilitating muscular disorder that is characterized by progressive muscle wasting, respiratory and cardiac impairments, paralysis, and premature death. This study will be published in the February 2013 issue of The American Journal of Pathology.http://medicalxpress.com/news/2013-01-tamoxifen-ameliorates-symptoms-duchenne-muscular.html
Diseases, Conditions, SyndromesTue, 15 Jan 2013 00:00:02 ESTnews277383672Study uncovers details of early stages in muscle formation and regeneration(Medical Xpress)—Researchers at the National Institutes of Health have identified proteins that allow muscle cells in mice to form from the fusion of the early stage cells that give rise to the muscle cells.http://medicalxpress.com/news/2013-01-uncovers-early-stages-muscle-formation.html
Medical researchWed, 09 Jan 2013 06:50:03 ESTnews276935407Molecular 'two-way radio' directs nerve cell branching and connectivity(Medical Xpress)—Working with fruit flies, Johns Hopkins scientists have decoded the activity of protein signals that let certain nerve cells know when and where to branch so that they reach and connect to their correct muscle targets. The proteins' mammalian counterparts are known to have signaling roles in immunity, nervous system and heart development, and tumor progression, suggesting broad implications for human disease research. A report of the research was published online Nov. 21 in the journal Neuron.http://medicalxpress.com/news/2013-01-molecular-two-way-radio-nerve-cell.html
NeuroscienceMon, 07 Jan 2013 15:51:17 ESTnews276796220Vitamin D deficiency may contribute to alcohol-related muscular weaknessMyopathy refers to a muscular disease in which muscle fibers do not function, resulting in muscular weakness and wasting. Vitamin D deficiency is a well-recognized cause of myopathy, and excessive drinking is often associated with low or subnormal levels of vitamin D. A review of studies of the relationship between alcohol-related myopathy and vitamin D deficiency indicates that vitamin D deficiency might partly explain the occurrence of the frequently observed myopathy in chronic alcoholism.http://medicalxpress.com/news/2012-12-vitamin-d-deficiency-contribute-alcohol-related.html
AddictionFri, 14 Dec 2012 16:00:16 ESTnews274696452From degeneration to regeneration: Advances in skeletal muscle engineeringA study published today in BioMed Central's open access journal Skeletal Muscle reports of a new therapeutic technique to repair and rebuild muscle for sufferers of degenerative muscle disorders. The therapy brings together two existing techniques for muscle repair – cell transplantation and tissue engineering – specifically, mesoangioblast stem cells delivered via a hydrogel cell-carrier matrix.http://medicalxpress.com/news/2012-11-degeneration-regeneration-advances-skeletal-muscle.html
Medical researchMon, 26 Nov 2012 13:21:38 ESTnews273158490New MRI technique allows detailed imaging of complex muscle structures and muscle damageTU/e and the Academic Medical Center in Amsterdam have together developed a technique that allows detailed 3D imaging of complex muscle structures of patients. It also allows muscle damage to be detected very precisely. This new technique opens the way to much better and more patient-friendly diagnosis of muscular diseases. It also allows accurate, non-invasive muscle examinations among top athletes. Martijn Froeling will receive a PhD for this research at TU/e today, Monday 29 October.http://medicalxpress.com/news/2012-10-mri-technique-imaging-complex-muscle.html
Medical researchTue, 30 Oct 2012 09:50:05 ESTnews270807335Researchers solve key part of old mystery in generating muscle massWorking with mice, Johns Hopkins researchers have solved a key part of a muscle regeneration mystery plaguing scientists for years, adding strong support to the theory that muscle mass can be built without a complete, fully functional supply of muscle stem cells.http://medicalxpress.com/news/2012-09-key-mystery-muscle-mass.html
Medical researchThu, 27 Sep 2012 13:37:34 ESTnews267971821UH Case Medical Center offers novel scarless procedure for rare conditionUniversity Hospitals (UH) Case Medical Center is one of five institutions nationwide performing a novel scarless procedure that restores swallowing function in some patients with achalasia, a rare condition where the esophagus is unable to move food into the stomach. Per-oral endoscopic myotomy (POEM) is a state-of-the-art technique to treat patients without any external incisions or outside scars. With POEM, surgeons enter through the mouth and tunnel an endoscope down the esophagus to cut the muscle fibers to open the esophagus, allowing food to enter the stomach.http://medicalxpress.com/news/2012-09-uh-case-medical-center-scarless.html
SurgeryMon, 24 Sep 2012 15:47:18 ESTnews267720430At the right place at the right time—new insights into muscle stem cellsMuscles have a pool of stem cells which provides a source for muscle growth and for regeneration of injured muscles. The stem cells must reside in special niches of the muscle for efficient growth and repair.http://medicalxpress.com/news/2012-09-timenew-insights-muscle-stem-cells.html
Medical researchMon, 17 Sep 2012 10:32:50 ESTnews267096761New study: Running mechanics, not metabolism, are the key to performance for elite sprintersSprinters competing in the 2012 Olympics might assume their championship performance is the result of their fuel-efficient physiology.http://medicalxpress.com/news/2012-08-mechanics-metabolism-key-elite-sprinters.html
OtherWed, 01 Aug 2012 13:45:13 ESTnews263047433Research shows mice brains are 'very wired up' at birth, suggests experience selects which connections to keepAsk the average person the street how the brain develops, and they'll likely tell you that the brain's wiring is built as newborns first begin to experience the world. With more experience, those connections are strengthened, and new branches are built as they learn and grow.http://medicalxpress.com/news/2012-06-mice-brains-wired-birth.html
NeuroscienceWed, 06 Jun 2012 13:40:01 ESTnews258206913Genetic variant increases risk of heart rhythm dysfunction, sudden deathCardiovascular researchers at the University of Cincinnati (UC) have identified a genetic variant in a cardiac protein that can be linked to heart rhythm dysfunction.http://medicalxpress.com/news/2012-05-genetic-variant-heart-rhythm-dysfunction.html
CardiologyWed, 30 May 2012 12:00:01 ESTnews257590200Researchers gain new insights into structure of heart muscle fibersA study led by researchers from McGill University provides new insights into the structure of muscle tissue in the heart &#150; a finding that promises to contribute to the study of heart diseases and to the engineering of artificial heart tissue.http://medicalxpress.com/news/2012-05-gain-insights-heart-muscle-fibers.html
CardiologyMon, 28 May 2012 15:00:03 ESTnews257415177Invasive treatment strategy may increase survival for patients with certain neuromuscular disorderPatients with a cardiac irregularity and myotonic dystrophy type 1 (a severe neuromuscular disorder with a high risk of sudden death) who received an invasive treatment strategy that included testing of their heart's electrical conduction system and if needed, implantation of a device such as a pacemaker, had an associated higher rate of 9-year survival compared to patients treated noninvasively, according to a study in the March 28 issue of JAMA.http://medicalxpress.com/news/2012-03-invasive-treatment-strategy-survival-patients.html
CardiologyTue, 27 Mar 2012 16:00:05 ESTnews252082161Fasudil bypasses genetic cause of spinal birth defectScientists from the Ottawa Hospital Research Institute (OHRI) and the University of Ottawa (uOttawa) have discovered that a drug called fasudil can extend the average lifespan of mice with Spinal muscular atrophy (SMA) from 30.5 days to more than 300 days. The study is published today in BioMed Central's open access journal BMC Medicine, by Dr. Rashmi Kothary, his graduate student Melissa Bowerman and others.http://medicalxpress.com/news/2012-03-fasudil-bypasses-genetic-spinal-birth.html
Diseases, Conditions, SyndromesTue, 06 Mar 2012 19:00:02 ESTnews250274689Unusual alliances enable movementSome unusual alliances are necessary for you to wiggle your fingers, researchers report.http://medicalxpress.com/news/2012-02-unusual-alliances-enable-movement.html
GeneticsWed, 08 Feb 2012 10:45:58 ESTnews247920331Exercise triggers stem cells in muscleUniversity of Illinois researchers determined that an adult stem cell present in muscle is responsive to exercise, a discovery that may provide a link between exercise and muscle health. The findings could lead to new therapeutic techniques using these cells to rehabilitate injured muscle and prevent or restore muscle loss with age.http://medicalxpress.com/news/2012-02-triggers-stem-cells-muscle.html
Medical researchMon, 06 Feb 2012 12:39:51 ESTnews247754383Adult stem cells use special pathways to repair damaged muscle (w/ Video)When a muscle is damaged, dormant adult stem cells called satellite cells are signaled to "wake up" and contribute to repairing the muscle. University of Missouri researchers recently found how even distant satellite cells could help with the repair, and are now learning how the stem cells travel within the tissue. This knowledge could ultimately help doctors more effectively treat muscle disorders such as muscular dystrophy, in which the muscle is easily damaged and the patient's satellite cells have lost the ability to repair.http://medicalxpress.com/news/2011-12-adult-stem-cells-special-pathways.html
Medical researchThu, 01 Dec 2011 15:54:25 ESTnews241977204