It is commonly accepted that phonology is the exclusive domain of the left hemisphere. However, this pattern of lateralization, which posits a right visual field advantage, has been questioned by several studies. In fact, certain factors such as characteristics of the stimuli and subjects{\textquoteright} handedness can modulate the right visual field advantage. Thus, the goal of this study was to compare the hemispheric dynamics of right-handers and left-handers during a divided visual field presentation of words that varied in terms of their phonological transparency. For non-transparent words, the left hemisphere seems more competent in both handedness groups. With regard to transparent words, the right hemisphere of both groups also appears competent. Surprisingly, left-handers achieved optimal processing with a functionally isolated left hemisphere, whereas right-handers needed the participation of both hemispheres. The pattern of performance cannot be fully explained by either the callosal or the direct access model.