Huckleberry Hound became the first animated series to win an Emmy, and The Flintstones was the first animated show to air in prime time. (Fred and Wilma Flintstone were also the first married couple in TV history to be shown sleeping in the same bed.)

Barbera even became a cartoon character himself at least once, appearing with Bill Hanna at the wedding of Pebbles Flintstone and Bamm-Bamm Rubble in the 1993 animated TV movie I Yabba-Dabba Do!