Oncogenic mutations disrupt the regulatory circuits that govern cell fate, endowing neoplastic cells with the ability to survive, proliferate, and invade independently of contextual constrains. Metastatic colonization of target organs is the ultimate manifestation of this antisocial behavior of cancer cells and is the immediate cause of death in most cancer patients. In most prevalent cancers, cancer cells that have disseminated prior to surgery remain latent in target organs for extended periods of time, offering a window of opportunity for therapeutic treatment.