- Part 3: Tumor samples and associated pathology data (Gleason score) and clinical data
(PSA values and patient's outcome) are obtained from a prostate tissue repository at
the Gelb Center of the Dana-Farber Cancer Institute. Samples are analyzed to correlate
eIF2α phosphorylation, Gleason scores, and time to PSA failure.

PROJECTED ACCRUAL: A total of 600 patients and 1,000 stored tissue samples will be accrued
for this study.

- Able to donate 10 mL of blood for fatty acid analysis in red blood cells

- No concurrent diagnoses that may interfere with measurements of fatty acids in
red blood cell membranes, including the following:

- Severe anemia (i.e., hemoglobin < 9 g/dL)

- Familial dyslipoproteinemia

- Liver cirrhosis

- Advanced renal failure

- Malabsorption syndrome

- Other disease of lipid metabolism

- Part 2: Patients who participated in part 1 who were subsequently diagnosed with
prostate cancer and are pursuing a total prostatectomy at BWH OR patients referred to
BWH from independent physicians for prostate cancer surgery

- Patients with indication for radical prostatectomy who refuse surgery or
schedule it at a location other than BWH are ineligible

- Part 3: Tissue samples from the prostate tumor registry at the Dana-Farber Cancer
Institute

Name

Location

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