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So, the cup of neverending youth means that with just its stats, if you have no health, you will be regerating 50 HP/5 and if you have no mana you will regen 25 MP/5. If you get you HP regen up to 70, this would equate to 175 HP/5 (35 per second).

Good tank stats plus amazing lane/pushing potential. This item, combined with the reverie, would mean only having to return to fountain to buy. It might not be particularly practical in a team fight but definitely good for pushing.

Let me know what you think

Edit: The uniques would not stack. So, having a chalice of harmony + cup of neverending youth would not result in 250% increased mana regen. Only the higher value would be used.