This drug may cause or make heart failure worse. It may raise the chance of chest pain or heart attack. Talk with your doctor.

A small number of people may have more acid in their blood. Metformin may cause this. It may happen in people whose liver or kidneys do not work the right way.

You may only get this drug through the AVANDIA-Rosiglitazone Medicines Access Program.

Please read the medication guide.

Avoid

If you have an allergy to metformin, rosiglitazone, or any other part of this drug.

Tell your doctor if you are allergic to any drugs. Make sure to tell about the allergy and what signs you had. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.

If you have any of these health problems: Acidic blood problem, drink too much alcohol, fluid loss, kidney disease, liver disease, very weak heart, or type 1 diabetes.

If you are having an x-ray with dye.

If you are breast-feeding.

Precautions

Wear disease medical alert ID (identification).

Do not run out of this drug.

Stop this drug for 2 days after you have an x-ray with dye.

Use care if you are having surgery, if you have had a heart attack, bad infection, or stroke, or if you are 80 years of age or older and have not had your kidney function tested.

If you have heart disease, talk with your doctor.

If you have high cholesterol, talk with your doctor.

If you have lung disease, talk with your doctor.

If you have a weak heart, talk with your doctor.

Check your blood sugar as you have been told by your doctor.

Have your blood work checked often. Talk with your doctor.

Have an eye exam and visit the foot doctor every year.

Check all drugs you are taking with your doctor. This drug may not mix well with some other drugs.

Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.

Do not drive if your blood sugar has been low. There is a greater chance of you having a crash.

Avoid beer, wine, or mixed drinks.

There is a chance of pregnancy in women of childbearing age who have not been ovulating.

The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.