Alex J ShorttCells for Sight Transplantation and Research Programme and Ocular Biology and Therapeutics Division, University College London Institute of Ophthalmology, London, United Kingdom Moorfields Eye Hospital National Health Service Foundation Trust, London, United Kingdom University College London Clinical Trials Unit, London, United KingdomStem Cells Transl Med 3:265-75. 2014

..The majority of cases result from ulceration and scarring following infection or trauma, but in a proportion corneal epithelial stem cell (SC) deficiency leads to an inability to maintain a healthy corneal surface...

..To determine, using objective measures, the outcome of ex vivo cultured limbal epithelial stem cell (LESC) transplantation performed in compliance with good manufacturing practice using a novel culture system without 3T3 feeder cells...

Alex J ShorttCells for Sight Transplantation and Research Programme and Ocular Biology and Therapeutics Division, University College London Institute of Ophthalmology, London, United Kingdom Moorfields Eye Hospital National Health Service Foundation Trust, London, United Kingdom University College London Clinical Trials Unit, London, United KingdomStem Cells Transl Med 3:265-75. 2014

..The COASTL tool showed that following allo-CLET there was a decrease in LSCD severity and an increase in visual acuity up to 12 months post-treatment, but thereafter LSCD severity and visual acuity progressively deteriorated. ..

..These data reveal a novel function for CTGF in the regulation of epithelial tissue repair beyond its established role in fibrosis, and further highlight the complexity of TGFbeta regulation of epithelial cell function...

Localisation of epithelial cells capable of holoclone formation in vitro and direct interaction with stromal cells in the native human limbal crypt

Marc A DziaskoDepartment of Ocular Biology and Therapeutics, UCL Institute of Ophthalmology, London, United KingdomPLoS ONE 9:e94283. 2014

..From these observations we present a three dimensional reconstruction of the LESC niche in which the stem cell is closely associated and maintained by both dendritic pigmented limbal melanocytes and elongated limbal stromal cells. ..

Pars plana lensectomy for the management of ectopia lentis in children

..It may also occur as an isolated abnormality in an otherwise healthy individual. Surgical intervention is necessary when lens subluxation causes a significant refractive error resulting in amblyopia...