Abstract

Aim

We aimed to establish a laboratory prognostic index (LPI) in patients with advanced non- small cell lung cancer (NSLCL) based on clinical and histological characteristics, hematologic and biochemical basal parameters and their effects on survival. The predictive value of LPI on NSCLC survival was evaluated.

Methods

The study retrospectively reviewed 462 patients with advanced NSCLC diagnosed between the years of 2000-2009 in a single institution. Twenty one clinical, hematological and biochemical factors were evaluated with univariate and multivariate analysis. A laboratory prognostic index (LPI) was developed based on WBC, LDH, ALB, CA and ALP levels with univariate and multivariate stepwise Cox regression analyses. LPI was classified into 3 groups as LPI 0: normal laboratory findings, LPI 1: one abnormal laboratory finding, and LPI 2: at least 2 abnormal laboratory findings.

Conclusions

LPI is an independent prognostic index for advanced NSCLC and might be helpful to predict the survival when combined with clinical parameters. LPI is an inexpensive an easily accessible indicator which might be used for treatment decisions and patient follow-up.