QUANTITATIVE DETERMINATION OF ETHACYSINE IN TABLETS BY SPECTROFLUOROMETRY AS ITS SULFONE

Mykola Blazheyevskiy, Vladyslav Ievtukhov, Andrey Doroshenko

Abstract

The new method was elaborated for quantitative determination of ethacysine hydrochloride (the diethylamino analog of ethmozine) (ЕТ) in the form of corresponding sulfonic derivative obtained with the use of potassium hydrogenperoxomonosulphate, through the spectrofluorometry (λex = 264 nm/ λеm = 380 nm). Linear concentration dependence was preserved in the concentrations interval (1-8)∙10-6 mol/l ЕТ, lgI=97047c – 0.003 (r=0,999). LOQ =1.1∙10-6 mol/l. It was showed that in the determination of ET in the tablets 50 mg (Olainfarm, Latvia) using the developed method, RSD =1.7% (accuracy, δ =- 0.2%).