This gene encodes a paired-like homeodomain transcription factor in the developing pituitary gland. Expression occurs prior to and is required for expression of pou domain transcription factor 1 which is responsible for pituitary development and hormone expression. Mutations in this gene have been associated with combined pituitary hormone deficiency-2 as well as deficiencies in luteinizing hormone follicle-stimulating hormone growth hormone prolactin and thyroid-stimulating hormone. [provided by RefSeq Sep 2011]

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