placebo group within each cohort receive 3 injections of normal saline 28 days apart

normal saline injection: 3 cohorts of normal saline injection

Other: Placebo

3 cohorts of normal saline injection

Eligibility

Ages Eligible for Study:

18 Years to 40 Years

Genders Eligible for Study:

Both

Accepts Healthy Volunteers:

Yes

Criteria

Inclusion Criteria, Healthy adults:

If female, not breastfeeding, not pregnant, not planning pregnancy during study period), and willing to consistently use an adequate method of contraception and have repeated pregnancy tests.

In good health with normal laboratory results

Willing to comply with study restrictions, study schedule, and can be reliably contacted

Exclusion Criteria:

Currently consumes alcohol in excess of 2 drinks per day for men or 1 drink per day for women.

current use or likely requirement for medications with potential for liver injury or effect immune system

History of event or condition such as anaphylaxis, severe allergic reactions, serious reactions to any vaccines, or other events that might increase risk of reaction to an investigational disease

History of diabetes, cancer, autoimmune or immunosuppressive disease or chronic such as HIV, Hepatitis B or C

Contacts and Locations

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study.
To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below.
For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01537185