Determination of Various Semen Parameters and Sex Hormone Levels in Subfertile Men during Kallikrein Therapy

Abstract

During the last years several groups have shown that hog pancreatic kallikrein is able to stimulate motility of hypokinetic spermatozoa (Schill et al., 1974; Leidl et al., 1975; Steiner et al., 1977; Bratanov et al., 1978). The in vitro studies were complemented by clinical investigations showing a statistical significant improvement of sperm motility after systemic administration of kallikrein to asthenozoospermic and oligozoospermic men (Hofmann et al., 1975; Schill, 1975a, g.; Lunglmayr, 1976; Tauber et al., 1977; Homonnai et al., 1978; Schirren, 1978). Furthermore, kallikrein treatment of subfertile men with reduced number of spermatozoa led to a significant increase of the total sperm output with a maximum 2 to 3 months after initiation of the therapy, which could recently be confirmed by a double blind trial (Schill, 1977).