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Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:query proteins and first shell of interactors

white nodes:second shell of interactors

Node Content

empty nodes:proteins of unknown 3D structure

filled nodes:some 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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Cooccurence

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[Homology]

Score

PBAL39_04753

Biotin carboxyl carrier protein of acetyl-CoA carboxylase (159 aa)

Predicted Functional Partners:

PBAL39_04758

Biotin carboxylase, subunit of acetyl CoA carboxylase (446 aa)

0.999

accA

Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha ; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (320 aa)

0.984

accD

Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta ; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (281 aa)

0.983

PBAL39_04748

Beta-ketoacyl-ACP synthase III ; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and/or straight-chain of fatty acids (329 aa)

0.980

PBAL39_24450

Malonyl CoA-acyl carrier protein transacylase (293 aa)

0.972

PBAL39_11452

Putative biotin--(Acetyl-CoA carboxylase) synthetase (256 aa)

0.945

PBAL39_11472

3-oxoacyl-(Acyl carrier protein) synthase (360 aa)

0.944

PBAL39_09996

Beta-ketoacyl-[acyl-carrier-protein] synthase III (322 aa)

0.943

PBAL39_18069

Beta-ketoacyl-ACP synthase III ; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and/or straight-chain of fatty acids (334 aa)

a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1

node2

node1 accession

node2 accession

node1 annotation

node2 annotation

score

PBAL39_04748

PBAL39_04753

PBAL39_04748

PBAL39_04753

Beta-ketoacyl-ACP synthase III ; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and/or straight-chain of fatty acids

Biotin carboxyl carrier protein of acetyl-CoA carboxylase

0.980

PBAL39_04748

PBAL39_04758

PBAL39_04748

PBAL39_04758

Beta-ketoacyl-ACP synthase III ; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and/or straight-chain of fatty acids

Biotin carboxylase, subunit of acetyl CoA carboxylase

0.976

PBAL39_04748

PBAL39_04788

PBAL39_04748

PBAL39_04788

Beta-ketoacyl-ACP synthase III ; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and/or straight-chain of fatty acids

2-oxoisovalerate dehydrogenase, E1 component, alpha and beta fusion

0.821

PBAL39_04748

PBAL39_11452

PBAL39_04748

PBAL39_11452

Beta-ketoacyl-ACP synthase III ; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and/or straight-chain of fatty acids

Putative biotin--(Acetyl-CoA carboxylase) synthetase

0.505

PBAL39_04748

PBAL39_11472

PBAL39_04748

PBAL39_11472

Beta-ketoacyl-ACP synthase III ; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and/or straight-chain of fatty acids

3-oxoacyl-(Acyl carrier protein) synthase

0.872

PBAL39_04748

PBAL39_24450

PBAL39_04748

PBAL39_24450

Beta-ketoacyl-ACP synthase III ; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and/or straight-chain of fatty acids

Malonyl CoA-acyl carrier protein transacylase

0.991

PBAL39_04748

accA

PBAL39_04748

PBAL39_08579

Beta-ketoacyl-ACP synthase III ; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and/or straight-chain of fatty acids

Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha ; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA

0.941

PBAL39_04748

accD

PBAL39_04748

PBAL39_13527

Beta-ketoacyl-ACP synthase III ; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and/or straight-chain of fatty acids

Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta ; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA

0.946

PBAL39_04753

PBAL39_04748

PBAL39_04753

PBAL39_04748

Biotin carboxyl carrier protein of acetyl-CoA carboxylase

Beta-ketoacyl-ACP synthase III ; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and/or straight-chain of fatty acids

0.980

PBAL39_04753

PBAL39_04758

PBAL39_04753

PBAL39_04758

Biotin carboxyl carrier protein of acetyl-CoA carboxylase

Biotin carboxylase, subunit of acetyl CoA carboxylase

0.999

PBAL39_04753

PBAL39_04788

PBAL39_04753

PBAL39_04788

Biotin carboxyl carrier protein of acetyl-CoA carboxylase

2-oxoisovalerate dehydrogenase, E1 component, alpha and beta fusion

0.922

PBAL39_04753

PBAL39_09996

PBAL39_04753

PBAL39_09996

Biotin carboxyl carrier protein of acetyl-CoA carboxylase

Beta-ketoacyl-[acyl-carrier-protein] synthase III

0.943

PBAL39_04753

PBAL39_11452

PBAL39_04753

PBAL39_11452

Biotin carboxyl carrier protein of acetyl-CoA carboxylase

Putative biotin--(Acetyl-CoA carboxylase) synthetase

0.945

PBAL39_04753

PBAL39_11472

PBAL39_04753

PBAL39_11472

Biotin carboxyl carrier protein of acetyl-CoA carboxylase

3-oxoacyl-(Acyl carrier protein) synthase

0.944

PBAL39_04753

PBAL39_18069

PBAL39_04753

PBAL39_18069

Biotin carboxyl carrier protein of acetyl-CoA carboxylase

Beta-ketoacyl-ACP synthase III ; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and/or straight-chain of fatty acids

0.924

PBAL39_04753

PBAL39_24450

PBAL39_04753

PBAL39_24450

Biotin carboxyl carrier protein of acetyl-CoA carboxylase

Malonyl CoA-acyl carrier protein transacylase

0.972

PBAL39_04753

accA

PBAL39_04753

PBAL39_08579

Biotin carboxyl carrier protein of acetyl-CoA carboxylase

Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha ; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA

0.984

PBAL39_04753

accD

PBAL39_04753

PBAL39_13527

Biotin carboxyl carrier protein of acetyl-CoA carboxylase

Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta ; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA

0.983

PBAL39_04758

PBAL39_04748

PBAL39_04758

PBAL39_04748

Biotin carboxylase, subunit of acetyl CoA carboxylase

Beta-ketoacyl-ACP synthase III ; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and/or straight-chain of fatty acids

0.976

PBAL39_04758

PBAL39_04753

PBAL39_04758

PBAL39_04753

Biotin carboxylase, subunit of acetyl CoA carboxylase

Biotin carboxyl carrier protein of acetyl-CoA carboxylase

0.999

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Functional enrichments in your networkNote: some enrichments may be expected here (why?)

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Statistical background

For the above enrichment analysis, the following statistical background is assumed: