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Charge to Peer Reviewers:The peer review charge was developed in accordance with OMB guidelines, is consistent with NIOSH peer review practice, and is meant to ensure that credible and appropriate science is used in the development of its recommendations on the medical screening for workers exposed to nanoparticles.

The objectives of this document are to describe (1) the scientific evidence relevant to exposure to engineered nanoparticles, (2) the elements of an occupational medical screening program, and (3) the overall aspects of a good health surveillance program in identifying and preventing exposure to potential hazards. The charge to the Peer Reviewers is to review the document to determine whether

the hazard identification is a reasonable reflection of the available scientific studies,

the discussion of occupational health surveillance including medical screening is consistent with sound occupational health practice, and

the conclusions that form the basis of the recommendations are appropriate.

To facilitate review of this Current Intelligence Bulletin, the five questions below should be considered:

Do the data cited support the conclusions of the document?

Are the conclusions appropriate in light of the current understanding of the toxicological data?

Is medical surveillance appropriate at this time for workers with potential exposure to engineered nanoparticles; if so, what form(s) of medical surveillance are specific for such workers?

What are the potential benefits, adverse impacts, and limitations of medical screening of workers potentially exposed to engineered nanoparticles?

What are the potential benefits, adverse impacts, and limitations of establishing an exposure registry for workers exposed to engineered nanoparticles?

The Peer Reviewers will be provided all substantive public comments received in the NIOSH Docket Office by February 15, 2008.