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Lewis founded The Yogscast in 2008, with the goal of sharing Simon with the world. Since then, the channel has grown to become one of the largest in the UK and Lewis remains the de facto leader of the team - balancing Simon’s boldness with reason and caution.

Lewis was educated at King Edward VI Grammar School in Chelmsford and studied Chemistry at the University of Manchester from 2002 to 2006.
He also took Law for the first year, he failed the final exam and was dropped from the course, Lewis said he hated studying law. In 2000, Lewis, then only 16 years of age, entered The Daily Telegraph Young Science Writer Awards with his article "Breathe Slowly and Keep Asthma at Bay"[1]. In the article, Lewis reveals that he has had asthma his entire life, but his condition was improved by the Buteyko method. Lewis won the "Younger category" of the awards for his article on the alternative asthma treatment and had a picture taken with Princess Anne.
The Royal Society of Chemistry was the place of employment for Lewis Brindley while he worked there as a Freelance Science Writer/Journalist from August 2006 to September 2010. Lewis' experience included "writing news and features for the Royal Society of Chemistry's magazine Chemistry World, more than three hundred articles published," and "regular attendance at press briefings across the country and reporting back from conferences abroad, such as the EU Chemistry Congress held in September 2008 in Turin, Italy." Several of the articles that were written and published by Lewis in Chemistry World can be found on the website of the Royal Society of Chemistry.

Lewis' blood type is A, his grandmother's was O and his grandfather's was AB Positive.

Lewis' great grandmother was a French farmer.

Lewis once walked down Chelford High Street dressed as a Worm from the "Worms" series of video games for charity.

Lewis has been electrically shocked three times: Once whilst trying to fix a lightbulb in his bathroom whilst he was living in a student house, once when he was tased by a friend called Dave and another when he was trying to climb over an electric fence during The Duke of Edinburgh.

Lewis was pepper sprayed in Cadets.

Lewis' World of Warcraft character, Xephos, is a draenei hunter, his alternate character, Zephos, is human death knight, his other character, Xukuva, is a tauren paladin, and his additional character, Xephiel, is a blood elf hunter.

His username, "Xephos," was originally spelled "Zephos," as his main World of Warcraft character was called this. The name change came about when Lewis used the spelling "Xephos" for his Minecraft account's username, presumably due to the fact that Zephos was already taken.