Researchers Have Restored Consciousness In A Man Who Spent The Last 15 Years In A Vegetative State

Scientists at the French National Center for Scientific Research have used nerve stimulation to induce signs of consciousness in a man who has been in a vegetative state almost half his life. The unfortunate individual is still far from complete wakefulness, but his case demonstrates consciousness can be restored after a much longer time than previously thought.

The vagus nerve connects the brain to the gut, along with other parts of the body. Stimulation has been shown to sometimes offer benefits to people with depression or epilepsy. It’s also known to have a role in the process of waking from sleep, and in keeping us alert. Putting these pieces together, Dr Angela Sirigu wondered if it could play a role in restoring consciousness to patients with unresponsive wakefulness syndrome.

The longer a person is in a vegetative state, the less likely they are to recover, particularly of their own accord. In order to be confident any responses were a result of their intervention, Sirigu sought the patient who had gone the longest without improvement. The chosen individual had a car accident at the age of 20, and remained unresponsive 15 years later.

After a month of stimulation of the vagus nerve with a current of around a milliamp, the man was able to turn his head on request. His eyes could follow a moving object and he appeared to stay awake longer when read to. He also spontaneously opened his eyes wider when someone’s head rapidly approached his face.

Sirigu reports in Current Biology that electroencephalogram (EEGs) also showed increased brain activity, including in the theta waves used to define the differences between states of consciousness. Metabolic activity was found to have increased in the cortex and sub-cortex, indicating a need for more fuel among brain cells.

These tests led doctors to upgrade the patient’s status from unresponsive to “minimal consciousness”, and Sirigu to conclude in a statement: “Brain plasticity and brain repair are still possible even when hope seems to have vanished.”

PET images compare brain activity by region before and three months after vagus nerve stimulation

A year without increases in consciousness has been identified as the point where waking is unlikely to occur, and after 15, progress is rare indeed.

The vagus exerts its influence on the brain by inducing the release of the hormone norepinephrine (also known as noradrenaline). Norepinephrine also acts as a neurotransmitter, enhancing information sharing between brain regions. Sirigu and co-authors note that, besides bringing hope to the loved ones of those who are in states of limited consciousness, their observations provide insight into where consciousness lies within the brain.

The work, they write, identifies the parietal cortex as “a major player in guiding the expansion of neural activity across brain regions”, promoting further study on this part of the brain.