Medical Journal of the Islamic Republic Of Iran http://mjiri.iums.ac.ir
Medical Journal of The Islamic Republic of Iran (MJIRI) - Journal articles for year 2001, Volume 14, Number 4Yektaweb Collection - http://www.yektaweb.comen2001/2/13THE ASSOCIATION OF THYMOMA AND SUPERFICIAL PEMPHIGUS IN AN OLD WOMANhttp://mjiri.iums.ac.ir/browse.php?a_id=850&sid=1&slc_lang=en
The association of pemphigus and thymoma is real, although rare. We report
a 73-year-old woman presenting with cutaneous bullac and erosions superimposed
on erythematous and urticarial plaques, and a positive Nikolsky sign. She.
had a large mediastinal mass that proved to be a benign thymoma. Her skin biopsy
and direct immunofluorescence test were suggestive of superficial pemphigus.
M DANESHPAZHOOHINTRALARYNGOTRACHEAL GOITER: A CASE PRESENTATION AND REVIEW OF THE LITERATUREhttp://mjiri.iums.ac.ir/browse.php?a_id=849&sid=1&slc_lang=en
Thyroid tissue located within the upper airway has received only sparse attention
in the English literature. Aberrant benign thyroid masses may present as
either an unrelated autopsy finding or with symptoms such as dyspnea, hemoptysis
or adult -onset asthma. There is no place for medical management in the therapy
of these lesions, although the appropriate surgical procedure is not clearly established.
In this article a patient with respiratory distress and subglottic goiter is presented.
She had subtotal thyroidectomy performed for goiter about 10 years ago.
She was managed with tracheotomy and submucosal resection of subglottic thyroid
tissue, followed by iodine ablation therapy and thyroid hormone replacement.
HR DAVARIPANCREATIC SCHWANNOMA: A CASE REPORThttp://mjiri.iums.ac.ir/browse.php?a_id=848&sid=1&slc_lang=en
Schwannomas may occur anywhere in the soft tissues or viscera, but do not
commonly involve the pancreas and retroperitoneum. We present a case of benign
pancreatic schwannoma which clinically simulated a malignant neoplastic
process.
S TORABI-NEZHADTHE ROLE OF ENDOSCOPY IN BILIARY ASCARIASIS: A CASE REPORThttp://mjiri.iums.ac.ir/browse.php?a_id=847&sid=1&slc_lang=en
Biliary ascariasis is a common disease in certain geographical areas of the
world. The adult form of the worm usually lives in the human intestine. Biliary
complications due to ascaris infestation are uncommon but are becoming an important
clinical problem, as fatal cases have been reported in the literature.
Many authors have recommended traditional surgical treatment for removal
of the worms. Since the development of endoscopy and related techniques, it has
become possible to treat biliary ascariasis endoscopically. In this article, we have
presented a case of biliary ascariasis which was diagnosed with ultrasonography
and confirmed with ERCP. We have also assessed the role of endoscopy in the
diagnosis and treatment of this disease in the literature.
H FROUTANINVASIVE GASTRIC MUCORMYCOSIS: REPORT OF A CASE AND REVIEW OF THE LITER ATUREhttp://mjiri.iums.ac.ir/browse.php?a_id=846&sid=1&slc_lang=en
Invasive gastric mucormycosis is a rare and fatal disease. We report a rare
case with longstanding SLE who presented with fever. Autopsy showed multiple
small shallow-based ulcers in the antrum. Histologic examination showed invasive
mucormycosis. This is a rare case of invasive gastric mucormycosis localized exelusively
in the stomach.
B GERAMIZADEHPARAGANGLIOMA OF THE FILUM TERMINALE EXTERNUM AND CONCURRENT ARTERIAL HYPERTENSION: A CASE REPORThttp://mjiri.iums.ac.ir/browse.php?a_id=845&sid=1&slc_lang=en
Paragangliomas are extra-adrenal counterparts of pheochromocytomas and are found
at various anatomical sites such as the retroperitoneum, mediastinum, jugular foramen and
carotid bifurcation, the latter two fonns being coined as chemodectomas.
The vertebral column, especially the llUllbar zone, is one of the rarest sites to be
involved by paragangliomas. These lesions may have secretory functions and produce
symptoms and signs mimicking cathecholamine oversecretion as was noticed in
our case.
A 60-year-old woman with a sacral mass, backache, and cauda equina syndrome
along with arterial hypertension is being presented who had been managed with antihypertensive
medications. Magnetic resonance imaging revealed involvement of sacral
canal and L5 and S 1 bodies producing a soft tissue bulge near the right buttock and
computed tomography showed a destructive sacral lesion.
Surgery was performed to resect the turnor mass and surprisingly the postoperative
blood pressure reached the normal range and henceforth antihypertensive therapy
was withheld. Tissue diagnosis of paraganglioma was made on the basis of histopathological
examination and ascertained by immunohistochemical study for
chromogranin, neuron specific enolase, synaptophysin and S 1 00 protein. One month
later the tumor site was subjected to radiation for any remnants following surgery.
After two years, the patient was found to be doing well and had been normotensive
Without medications.
Spinal paragangliomas are treated with total excision and irradiation for residual
tumor, if present. The role of immunohistochemistry could not be overemphasized
for diagnostic confirmation.
H SABERITHE PROTECTIVE EFFECT OF INDOMETHACINE ON SULFUR MUSTARD-INDUCED OCULAR DAMAGE IN THE RABBIT EYEhttp://mjiri.iums.ac.ir/browse.php?a_id=844&sid=1&slc_lang=en
Sulfur mustard, a bifunctional alkylating agent, causes severe eye injury. The
injury is a result of late inflammation, which is mediated by prostaglandins. Theoretically,
inhibition of prostaglandins by reagents such as indomethacine could
result in alleviation of clinical adverse effects. In this study, the protective effect
of topically applied indomethacine against sulfur mustard toxicity was assessed
on the rabbit eye. Ocular toxicity was studied by using light microscopy, electron
microscopy and visual inspection methods. Methods used in this assay showed
that 100 µL of indomethacine solution (0.5% W N) two hours before exposure
and throughout the experiment could markedly decrease the toxic effects of mustard.
SN OSTADINFLUENCE OF NERVE TISSUE-DERIVED NEUROTRANSMITTERS ON MAST CELL MIGRATIONhttp://mjiri.iums.ac.ir/browse.php?a_id=843&sid=1&slc_lang=en
In vitro culture systems using bone marrow cells from BALB/C mice were set up
in medium supplemented with spleen-derived medium. Bone marrow cells grown in
spleen-derived medium gave rise to cultures containing >97% mast cells. The cells
were used in polarisation chemotaxis assays with the intention of determining the
effect of nerve tissue-derived neurotransmitters on mast cell migration. Some available
neurotransmitters including (substance-p, histamine, serotonin, Dopa, noradrenaline,
acetylcholine, aspartic acid, epinephrine and nerve extracts) were tested. Mast
cells showed a significant morphological response to 10-3 and 10-4 M histamine, 10-9
M serotonin, and 10'2 M Dopa Nerve extracts induced some shape changes in mast cells.
P KERMANIZADEHEFFECT OF CYANIDE IN CARDIOPLEGIC SOLUTION ON ISOLATED RAT HEART FUNCTIONhttp://mjiri.iums.ac.ir/browse.php?a_id=842&sid=1&slc_lang=en
It has been known that cardiomyocytes possess a remarkable ability to downregulate
their energy expenditure on restricted 02 supply. However it has also
been speculated that an ability to suppress aerobic respiration and ATP utilization
could be a protective response to prolonged hypoxia.
Having the role of the cytochrome oxidase enzyme in mind, one can ask if its
inhibition by using cyanide has a role in improving the heart's function after the
cardioplegic period. In order to answer this question, the present study was carried
out on two groups of rats. The test and control groups included 10 male rats.
Each animal in both test and control groups received cyanide (LP., 1.6 mg/kg/
day) and saline (1 ml/day) respectively, and each heart experienced three stages:
1) normal activity, 2) cardioplegia, and 3) reperfusion stage. St-Thomas II
cardioplegic solution was used while it contained 0.5 mmol/L cyanide in the test
group. The results indicated that recovery percentage in the reperfusion stage, for
the De.L. v.P. and dp/dt parameters were significantly higher in the test
[(14S.1%±11.97) and (l30.97%±9.619)] than the control group [(91.62%±4.S9)
and (96.1 %±4.91)] [(P<0.01) and (p<0.005)]. H.R. parameters, the rate of coronary
solution flow, the variations of left ventricular diastolic pressure in the
reperfusion period and tissue pathologic damages did not show significant differences
between the two groups.
These results indicated that the application of cyanide in cardioplegic solution
induces an improvement of cardiac function in relation to the control group
which is likely to be due to the impact of cyanide on cytochrome oxidase.
D SHACKEBAEIPRELIMINARY COMPARATIVE STUDY OF ENTAMOEBA HISTOLYTICA AND ENTAMOEBA DISPAR BY PCR TECHNIQUE IN IRANhttp://mjiri.iums.ac.ir/browse.php?a_id=841&sid=1&slc_lang=en
It has been suggested that two distinct species exist within what was originally
known as Entamoeba histolytica and E. dispar. These are Entamoeba dispar
for the nonpathogenic and E. histolytica for the pathogenic fonn. Differentiation
of these two organisms is of great clinical importance since they are morphologically
indistinguishable and both fonns can infect the human intestinal cavity. A
study was carried out to differentiate E. histolytica from E. dispar by polymerase
chain reaction (PCR) using two sets of primers (p11plus p12 and p13 plus p14)
specific for either species of ameba. The extracted DNA was used for the identification
of the species in the stool and culture media by PCR. A total of 16 samples,
cysts and trophozoites, were analyzed. In all, 15 samples reacted with E. dispar
primers, resulting in the expected 10 I-bp PCR products however, none of these
reacted with E. histolytica primers. Only one sample reacted with E. histolytica
primers. Because of high sensitivity of the PCR method and the high risk of laboratory
contamination during processing and extracting DNA and its polymerization,
and because of many existing cultures of E. histolytica in the same laboratory,
the chance of contamination can not be ruled out in the single case of E.
histolytica. This preliminary study could be an introduction for a PCR -based epidemiological
study to detennine the importance of E. histolytica in Iran.
M FALLAHSUBTYPES OF α1-ADRENOCEPTORS IN RABBIT SAPHENOUS VEINhttp://mjiri.iums.ac.ir/browse.php?a_id=840&sid=1&slc_lang=en
We investigated the a,-adrenoceptor subtypes of rabbit saphenous vein which
has a mixed functional population of α1 and α2 -adrenoceptors. Lateral saphenous
veins were obtained from male rabbits weighing 3.20-4 kg, which were killed by
overdose with pentobarbitone sodium (i.v. injection). They were easily dissected
out and placed in cold, oxygenated modified Krebs-Henselite solution (Krebs).
Each preparation was cut transversely into 3-4 mm rings and suspended between
thick wire supports. The vein rings were mounted in 10 mL isolated organ bath,
bathed in Krebs maintained at 37°C and gassed with 95% 02 plus 5% CO2, Cumulative
concentration-response curves (CCRC) were constructed by increasing
the concentration of the agonists in half-log increments. The preparations were
left for a further period of 45-60 min before re-exposure to the agonist. Competitive
antagonists like prazosin and rauwolscine were incubated in preparations at
least for 45 minutes prior to the onset of a second CCRC. The strategy was based
on using the a1-adrenoceptor selective agonist, phenylephrine (PE). Prazosin, an
α1 -adrenoceptor selective antagonist, competitively inhibited contractile responses
to phenylephrine with a pA2 value of 8, WB-41 0 1 had a pA2 of 8.6 but a low
Schild plot slope, while low potency was found with 5MU (PA2 7.2) and HV -723
(pA2 7.97). This data is not consistent with a definitive for αlA or αlN and taken
alone the evidence from prazosin is in favour of αIL' However the selective α2-
adrenoceptor antagonist delequamine inhibited phenylephrine-induced contractions.
Overall the data is consistent with phenylephrine-induced contractions being
mediated by a,- and a2 -adrenoceptors. The best estimate of the subtype of ajadrenoceptor
mediating contraction is aiL due to the relatively low absolute pA2
values for prazosin.
M MOHAMMADI NAGHADEH DIFFERENTIAL EXPRESSION OF SURFACE MARKERS CD45RB AND CD44 ON MURINE CD8+ CELLShttp://mjiri.iums.ac.ir/browse.php?a_id=839&sid=1&slc_lang=en
Considering the emerging importance of phenotypic markers as indicators of cell function
and differentiation, we studied patterns ofCD44 and CD45RB expression in CD8+ murine T
cells with prior exposure to antigen or staphylococcal enterotoxin B ( SEB ). Following in
vivo priming with two purified protein derivatives (one from a virulent WHO strain and the
other from an avirulent strain), T cell enrichment was performed on murine spleen cells and
followed by in vitro restimulation with SEB. Flow-cytometry studies were done to monitor
the expression ofCD44 or CD45RB. Results indicate that primed or memory CD8+ cells do
not display any significant change in the expression ofCD45RB. The expression ofCD44
exhibited significant variations among unprimed and primed mice and between different antigens.
We were also able to see differential expression relevant to the virulence of the bacterial
strain. This study suggests that by activation of those populations ofCD8+, CD44+ cells,
resistance to virulent bacteria occurs.
M EBTEKARANTISPASMODIC EFFECT OF AERIAL PART OF TEUCRIUM POLIUM L. ESSENTIAL OIL ON RAT ISOLATED ILEUM IN VITROhttp://mjiri.iums.ac.ir/browse.php?a_id=838&sid=1&slc_lang=en
Teucrium polium L. (Lamiaceae) is used in the traditional medicine of Iran
for the treatment of disorders of the gastrointestinal tract. The essential oil from
the aerial parts of T polium was assessed for antispasmodic activity and compared
with the effect of atropine and dicyclomine. Acetylcholine and KC I were
used for induction of contraction on rat isolated ileum. Teucrium polium essential
oil (TPEO) at concentrations of 8.6 to 34.4 µg/mL attenuated the maximum inducible
response to acetylcholine concentration-response curve. It also inhibited
the response to 80 mM KC I in a concentration dependent manner (pD2= 1.2±0 .13).
Dicyclomine (3.46 & 34.6 ng/mL) also reduced the response to acetylcholine on
rat isolated ileum and inhibited KC1-induced contractions while atropine only
inhibited the response to acetylcholine. This study shows that TPEO is a relaxant
of rat isolated ileum and may have some clinical benefits for gastrointestinal disorders
such as colic.
H SADRAEISADRAEITHE EFFECT OF ASCORBIC ACID ON BLOOD HISTAMINE LEVEL AND DELAYED-TYPE HYPERSENSITIVITY IN GUINEA PIGShttp://mjiri.iums.ac.ir/browse.php?a_id=836&sid=1&slc_lang=en
The effect of ascorbic acid on blood histamine level and delayed-type
hypersensitivity was studied in thirty male guinea pigs. Animals were sensitized
to B.C.G., trichophytin and mallein during the first four weeks. The diet
was ad libitum during this period. After this "sensitization period" animals
w er e tested intradermally with tuberculin, trichophytin and mallein. The number
and diameter of positive delayed type hypersensitivity responses (antigenic
and cumulative scores) were evaluated as an effector state of cell mediated
immunity. Animals were fed low, adequate or high ascorbate diets (0.5,
2.0 or 50 mg ascorbate x 100g body wt-1xd-1) for the next four weeks. Antigenic
and cumulative scores were evaluated after this period once again.
Mean liver ascorbate paralleled dietary intake and the values obtained
w er e significantly different in the three groups. Blood histamine was significantly
depressed in the high ascorbate group compared to the adequate and
low ascorbate groups, and liver ascorbate was inversely correlated to blood
histamine levels (r= -0.97, p<0.001). Although mean antigenic and cumulative
scores in the low ascorbate group were lower than those of adequate and
high ascorbate groups, the differences were not significant.
It was concluded that ascorbate may enhance immune function through
detoxifying histamine, an immunodepressor compound. However, the
immunostimulatory effect of ascorbate on cell mediated immunity was not
confirmed in this study. In chronic ascorbate deficiency, there may be a predisposition
to infectious diseases due to depressed immune function, at least
because of disturbances in metabolism of other nutrients influencing immune
responsiveness, especially iron and folate.
M JALALISTUDY ON THE EF FICACY OF RECOMBINANT HEPATITIS B VACCINE IN IRANIAN INFANTShttp://mjiri.iums.ac.ir/browse.php?a_id=835&sid=1&slc_lang=en
In order to determine the efficacy of recombinant hepatitis B vaccine in Iranian
infants, we analyzed the efficacy of a recombinant hepatitis B vaccine in 115
infants aged 12-24 months born to HBsAg negative mothers who received three
doses of HBV Antibody to hepatitis B surface antigen (anti-HBs) was checked
after the third dose of the vaccine, 94.8% of the infants had developed protective
antibody levels. The vaccine was well-tolerated and no serious adverse effects
were reported.
This study is in agreement with a WHO report which recommends that the
easiest and most cost-effective strategy for the control and eventual eradication of
HBV would be to immunize all newborns with hepatitis B vaccine only [World
Health Organization report, 1984].
A ZAMANIIS BILE SCOLECIDAL?http://mjiri.iums.ac.ir/browse.php?a_id=834&sid=1&slc_lang=en
Spillage of scoleces is a major problem in surgery of hydatid cysts, because
each of them may develop into a new cyst if it settles on a suitable site such as the
peritoneum. Many surgeons believe that scoleces in ruptured hydatid cysts of the
liver containing bile are not able to develop new cysts, because bile kills thein. In
order to prove this idea, the viability of scoleces in such cysts was assessed and
the effect of bile on live scoleces of unruptured liver cysts of sheep and human
beings was also assessed in the laboratory. It was concluded that bile is not
scolecidal, and an unfavorable environment is the cause of death bf the •scoleces.
Scoleces in ruptured cysts may be alive and able to develop a new cyst. Therefore
the surgeon should use all necessary precautions to prevent spillage.
A A. IZADPANAHENVIRONMENTAL FACTORS AND POLYCYSTIC OVARIEShttp://mjiri.iums.ac.ir/browse.php?a_id=833&sid=1&slc_lang=en
This study was designed to investigate the effect of environmental factors on
the appearance of polycystic ovaries (PCO) during the first two decades of life.
Ninety-four female-female twins who underwent a transabdominal ultrasound
at the Royal Hospital for Women were sent a questionnaire asking about their
birth details, feeding history as a baby, childhood illnesses and vaccination as
well as exercise patterns. Seventy-seven subjects returned the questionnaire. All
of the variables were studied in two groups of subjects those with ultrasound
evidence of polycystic ovaries (US-PCO, n= 37) and those with normal ovaries
(US-normal, n= 40). The data were also analyzed in a group of scan-discordant
twins (7 pairs) in whom one of the twins had US-PCO and the co-twin had normal
ovaries.
Analyzing the data from the whole database suggested that US-PCO subjects
had lower birth weight compared to US-normals. Vaccination against mumps
was also found to be significantly higher in the US-PCO group compared with
US-normals. Matched results for scan-discordant twins did not confirm these results.
Other environmental variables such as feeding history, type of delivery,
birth order and physical activity during the first 20 years of age did not seem to
have any significant influence on the prevalence of PCO. No significant difference
was found in childhood illnesses between the groups.
In conclusion, this study examined the effect of some environmental factors during
childhood and early adulthood. Analyzing the whole database and scan-discordant
twins failed to show any particular environmental factor associated with PCO.
SHAYESTEH JAHANFAREVALU ATI ON OF THE CAUSES OF CHOLESTASIS IN INFANTShttp://mjiri.iums.ac.ir/browse.php?a_id=832&sid=1&slc_lang=en
During a period of three years from 1996 to 1998, 124 infants (64 male and
60 female) with an age range of 1-6 months (mean age 1.5 months) with cholestasis
were studied. Idiopathic neonatal hepatitis was the most common cause of
cholestasis, accounting for 48 cases with a rate of 3'8.70% in a total of 124 patients,
followed by galactosemia in 29 patients (23.38%) and extrahepatic biliary
atresia in 20 patients (16.12%).
The prompt identification and diagnostic assessment of these infants are imperative
to early surgical intervention (e.g. in biliary atresia) and specific medical
therapy (e.g. in galactosemia) and in order to institute effective nutritional and
medical support to allow optimal growth and development and prevent progressive
liver disease and death.
F FARAHMANDEFFEC T OF HEMODI ALYSIS ON TRACE ELEMENTS IN PATIENTS WITH ACUTE AND CHRONIC RENAL FAILUREhttp://mjiri.iums.ac.ir/browse.php?a_id=831&sid=1&slc_lang=en
Hemodialysis is being implicated in the development of metabolic disturbances,
as complications have been observed and the role of trace metals in their
development has been questioned. In 78 renal failure patients who underwent
hemodialysis, serum levels of zinc and copper were determined before and after
first hemodialysis. Acute and chronic renal failure patients were found to have
lower serum zinc levels before hemodialysis and higher levels after hemodialysis,
while serum copper levels were found to be higher before hemodialysis and
to increase further after hemodialysis. Disturbances in acid-base balance lead to
acidosis which can alter the binding, transport and excretion of these elements.
Dialysis fluid containing salts of trace elements may have also contributed to this
alteration of trace element levels.
I RASOOLIREFERENCE CHARTS FOR ARM, CHEST AND HEAD CIRCUMFERENCES OF SOUTH IRANIAN INFANTShttp://mjiri.iums.ac.ir/browse.php?a_id=830&sid=1&slc_lang=en
The reference charts for mid upper arm (MUAC), chest (CHC) and head
(HC) circumferences of a cohort of 317 healthy infants (153 boys and 164 girls)
born in Shiraz (Southern Iran) and monitored from birth for 2 years are presented.
Centiles for MUAC and HC lie below the Netherlands and US subjects respectively.
However, there is no suggestion of ill health for Iranian subjects. The use
of locally based MUAC, HC, and CHC charts are essential for clinical work in
Iran. Operational simplicity and measurement validity and accuracy suggest that
monitoring these measurements should be performed both by health workers in
the Iran primary health care system and by mothers for preventive measures as
well as child health promotion and development. The paper concludes that the
charts presented here are likely to be applied to the urban infant population of Iran
due to its structural representativeness and sophisticated methodology.
SMT AYATOLLAHIZ-PLA STY FOR TREATMENT OF THE RESIDUAL CAVITY AFTER P ILONIDAL SINUS EXCISIONhttp://mjiri.iums.ac.ir/browse.php?a_id=829&sid=1&slc_lang=en
In order to evaluate the outcome and complications of Z plasty in pilonidal
cyst repair, 90 patients with pilonidal cysts of the natal cleft were selected and
repaired by Z-plasty in Al-Zahra hospital. The patients were followed for 6 months
and complications such as seroma, infection and relapse were evaluated. The incidence
of seroma, infection and relapse after Z-plasty was 12%,3.3% and 3.6%,
respectively. These results show that Z-plasty is an effective form of operation for
pilonidal cyst treatment.
A BEHDADEARLY POST-OPERATIVE RESULTS AFTER TOTAL CORRECTION OF TETRALOGY OF FALL OT: THE EXPERIENCE IN SHIRAZ, IRANhttp://mjiri.iums.ac.ir/browse.php?a_id=828&sid=1&slc_lang=en
In order to compare early post-operative results in primary versus two-stage
repair of tetralogy of Fallot at Shiraz University of Medical Sciences, one􀁱hundred
and eleven patients with tetralogy of Fallot with right ventricle to pulmonary
artery continuity and no other major associated anomaly were repaired in one
center by one surgeon in a one or two-stage protocol. Those patients who were
initially palliated with shunt were either referred from other centers for total correction,
presented with cyanotic spells, or were shunted due to their severe and
diffuse right ventricular outflow tract obstruction or pulmonary artery branch stenosis
or hypoplasia. Hospital mortality and ratio of right to left ventricle pressure
after correction were compared between the primary and the two-stage groups as
early outcome indices. The patients were also divided to those who needed a
trans-annular (TAP) or a sub-annular patch and were compared.
In the primary group, 25 (37.3%) of the patients needed TAP, while in the
two-stage group 28 (63.6%) needed TAP. Requirement for TAP was increased
significantly with two-stage correction (p= 0.006, relative risk= 1.71, 95% CI=
1.16-2.5). Mortality was significantly higher in the primary group (p= 0.03, relative
risk= 3.94, 95% CI= 0.93-16.76). In the primary group TAP significantly
increased the mortality risk (p= 0.006, relative risk= 5.04, 95% CI= 1.5-16.89). In
the two-stage group, there was no significant difference in the mortality rate between
the patients with and without TAP. The TAP group had statistically significant
less time interval between shunt and total correction.
Our patients generally did better on two-stage repair, because of their older
age at operation. The long period of low pulmonary blood flow has induced unbalanced.
ventricles for them and exaggerated right ventricular outflow tract obstruction
due to muscle hypertrophy. In such patients, shunting will prepare the
left ventricle for accepting the extra blood volume that will reach it after total
correction.
A NAVABI SHIRAZICLINICAL FEATURES AND TREATMENT OUTCOME IN 26 CASES WITH Ki-l (CD30) POSITIVE ANAPLASTIC LARGE CELL LYMPHOMAhttp://mjiri.iums.ac.ir/browse.php?a_id=827&sid=1&slc_lang=en
In order to present the clinical features and outcome of patients with Ki-l
positive lymphoma and also the role of treatment modalities in this type of malignant
disease, twenty-six patients with peripheral lymphadenopathy and a biopsyproven
diagnosis ofKi-l positive lymphoma referring to the Radiation Oncology
Department during a seven year period were treated with chemotherapy and radiotherapy
according to the stage of the disease and after about 3 years of followup
the outcome was evaluated.
After an initial complete remission for a few months, most patients in advanced
stages and a few cases in early stages developed recurrence for whom
chemotherapy was started. The majority achieved remission again. After 3 years
of follow 'up 18 of 26 patients were alive with no evidence of disease.
As the behavior of this lymphoma is related to initial stage of disease rather
than to Ki-l expression, radiation therapy may be an acceptable modality adjunctive
to chemotherapy in patients with such lymphomas, particularly in those with
localized disease for getting better disease control.
AHMAD MOSALAEI