Causes of Leaky Gut?

Causes of Leaky Gut Syndrome (intestinal
permeability)

There are numerous causes of Leaky Gut Syndrome all associated with a break down in the normally healthy probiotic inner ecology or mircobiome. Whereas any of the factors below can individually or collectively cause temporary harm from which the micobiome can adapt and bounce back, repeated use or exposure over time will cause actual damage to the bowel epithelial cells and the tight juncture between them. This tight juncture breakdown creates a severe compromise to the integrity of the GI tract, allows passage of unwelcome toxins directly into the blood stream, thereby contributing to a variety of well documented disease related effects such as IBS (irritable bowel syndrome), Intestinal permeability (leaky gut), Crohn's disease (CD), ulcerative colitis (UC), collectively called inflammatory bowel disease (IBD). Advanced breakdown contributes to immune-mediated conditions characterized by a chronic inflammation of the gut such as Rheumatoid Arthritis (RA) and Systemic Lupus. (See our page: Signs and Symptoms).

Causes of leaky gut:

DRUGS: leaky gut will increase and be affected by OTC (over the counter) aspirin and related NSAID (nonsteroid anti-inflammatory drugs as well as Rx prescription drugs. (3)

Abstract:Acute and/or chronic alcohol ingestion has been shown to
exacerbate the morbidity and mortality rate associated with acute mechanical
and/or thermal trauma. While alcohol ingestion can affect many organs and
systems, clinical and preclinical studies indicate that
alcohol ingestion can cause a'leakygut'syndromewhich
in turn contributes to infection and systemic organ dysfunction. This study
investigated the acute effect of alcohol on
gutbarrier
function.

Abstract:The incidence of autoimmune diseases is increasing along with the
expansion of industrial
foodprocessing
and
foodadditive consumption. The intestinalepithelial
barrier, with its intercellular tight junction, controls the equilibrium
between tolerance and immunity to non-self-antigens.
Tight junction leakage is enhanced by many luminal components, commonly
used industrial
foodadditives
being some of them
. Glucose, salt, emulsifiers, organic solvents, gluten,
microbial transglutaminase, and nanoparticles are extensively and increasingly
used by the
foodindustry,
claim the manufacturers, to improve the qualities of
food.
However, all of the aforementioned additives increase
intestinalpermeabilityby breaching the integrity of tight junction
paracellular transfer.

Abstract: To investigate howintestinalepithelial
cells respond to contact with
Candidaalbicans,
an organism able to invade the bloodstream via the gastrointestinal tract, we
focused on the junction proteins occludin, E-cadherin, and desmoglein-2. ... These
experiments identify 2 E-cadherin cleavage events that are enhanced by contact
with
C. albicans: an intracellular
cleavage event that generates
a substrate for gamma-secretase and an
extracellular cleavage event that is temporally associated with
an increase in monolayerpermeability.