Cell Regulatory Systems:
Regulation of Transcription During the Cell Cycle:
Introduction.
An Emerging Role for Mammalian and Yeast CDKs in Transcriptional Regulation.
Cdk7 and Cdk8: Two Components of the Basal Transcription Machinery.
The pRB Family of Proteins.
The E2F Transcription Factor.
c-Myc Transcription Factor and its Partners.
Role of p53 as Transcription Factor and Growth Suppressor.
M Phase Repression of Transcription.
Conclusion.

Regulation of Transcription by Extracellular Signals:
Introduction.
Mechanisms of Signal Transmission to the Nucleus.
Mechanisms of Signal Transmission to the Nucleus.
Mechanisms of specificity and Diversity Generation in Signaling Pathways.
Modification of Transcription Factor Activity.
Perspectives and Future Directions.

Systemic Regulation:
Transcriptinal Regulation of Early Lymphocyte Development:
Introduction.
Regulation of Early B-cell Commitment and Differentiation.
Development Decisions in T Cells: Regulation of CD4 Transcription.
Conclusions.

Transcriptional Integration of Hormone and Metabolic Signals by Nuclear Receptors:
Introduction.
The Family and Its Ligands.
Targets and Genetics.
Modular Structure and Function.
Molecular Mechanisms of Transcriptional Regulation.
Platforms for Multiple Signal Integration.
Deregulation in Disease and Novel Therapeutic Targets.
Conclusions.

Description

An important and comprehensive review of an expanding research area. The book will combine all classical knowledge in the field with recent advances to provide a full and comprehensive coverage of the field.

Transcription factors are important in regulating gene expression, and their analysis is of paramount interest to molecular biologists studying this area. This book looks at the basic machinery of the cell involved in transcription in eukaryotes, the factors involved in transcription and progresses to look at the regulatory systems which control this machinery both within the cell and also in the wider systems of the mammalian organism.

Key Features

Comprehensive review of an increasingly important subject area

Editor is well-known in this area, and has gathered a team of respected international contributors

A unique collection of all recent work in this area, with no existing competition

Covers both transcription factors and their control, and also both normal and disease states