Although political satire was dangerous during much of the Soviet period, Krokodil was given considerable license to lampoon political figures and events. Typical and safe topics for lampooning in the Soviet era were the lack of initiative and imagination promoted by the style of an average Soviet middle-bureaucrat, and the problems produced by drinking on the job by Soviet workers. Krokodil also ridiculed capitalist countries and attacked various political, ethnic and religious groups that allegedly opposed the Soviet system. For example, at the time of the Doctors' plot it published a number of anti-semitic articles and cartoons.

Among the vocal compositions of Dmitri Shostakovich, who is known for his satirical character, there are 5 Romances on texts from Krokodil Magazine (1965), taken from the section of magazine where were published real-life nonsense texts.