If resources were not limited, what research projects would you pursue?Careful clinical phenotyping of 100,000 psychiatric patients, sequencing their entire genome, and identifying DNA variations that are associated with specific symptoms.

What is your leading hypothesis?Psychotic symptoms are caused by an insufficient 'bandwidth' of communication between cortical areas, leading to disturbed integration of information under demanding circumstances.Causes can be entirely different for individual patients, but they have a clear physical basis, which is largely genetically determined.

What piece of missing evidence would help prove it?There will probably be no single piece of evidence...