Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))* All genome coordinats were lifted-over on hg19.* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Elongation factor component of the super elongationcomplex (SEC), a complex required to increase the catalytic rateof RNA polymerase II transcription by suppressing transientpausing by the polymerase at multiple sites along the DNA.Elongation factor component of the little elongation complex(LEC), a complex required to regulate small nuclear RNA (snRNA)gene transcription by RNA polymerase II and III (PubMed:22195968,PubMed:23932780). Specifically required for stimulating theelongation step of RNA polymerase II- and III-dependent snRNA genetranscription (PubMed:23932780). ELL also plays an early rolebefore its assembly into in the SEC complex by stabilizing RNApolymerase II recruitment/initiation and entry into the pausesite. Required to stabilize the pre-initiation complex and earlyelongation. {ECO:0000269|PubMed:16006523,ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948,ECO:0000269|PubMed:22195968, ECO:0000269|PubMed:22252557,ECO:0000269|PubMed:23932780, ECO:0000269|PubMed:8596958}.

Serine/threonine-protein kinase that phosphorylatesSFPQ/PSF, HNRNPA1 and EIF4E. May play a role in the response toenvironmental stress and cytokines. Appears to regulatetranslation by phosphorylating EIF4E, thus increasing the affinityof this protein for the 7-methylguanosine-containing mRNA cap.Required for mediating PP2A-inhibition-induced EIF4Ephosphorylation. Triggers EIF4E shuttling from cytoplasm tonucleus. Isoform 1 displays a high basal kinase activity, butisoform 2 exhibits a very low kinase activity. Acts as a mediatorof the suppressive effects of IFNgamma on hematopoiesis. Negativeregulator for signals that control generation of arsenic trioxideAs(2)O(3)-dependent apoptosis and anti-leukemic responses.Involved in anti-apoptotic signaling in response to serumwithdrawal. {ECO:0000269|PubMed:11154262,ECO:0000269|PubMed:11463832, ECO:0000269|PubMed:12897141,ECO:0000269|PubMed:16111636, ECO:0000269|PubMed:17965020,ECO:0000269|PubMed:18299328, ECO:0000269|PubMed:20823271,ECO:0000269|PubMed:20927323, ECO:0000269|PubMed:21149447}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at