Antimicrobial drug resistance is of great importance to healthcare facilities globally, especially in relation to the diagnosis and management of patients with life-threatening infections such as pneumonia and blood stream infections. The battle continues between several Gram-negative and Gram-positive pathogens and the introduction of new antibiotics such as oxyimino-cephalosporins, carbapenems, linezolid, daptomycin, and tigecycline for the management of patients with critical bacterial infections.