Bicillin C-R Tubex

SIDE EFFECTS

As with other penicillins, untoward reactions of the sensitivity phenomena
are likely to occur, particularly in individuals who have previously demonstrated
hypersensitivity to penicillins or in those with a history of allergy, asthma,
hay fever, or urticaria.

Nervous System: Nervousness; tremors; dizziness; somnolence;
confusion; anxiety; euphoria; transverse myelitis; seizures; coma. A syndrome
manifested by a variety of CNS symptoms such as severe agitation with confusion,
visual and auditory hallucinations, and a fear of impending death (Hoigne's
syndrome), has been reported after administration of penicillin G procaine and,
less commonly, after injection of the combination of penicillin G benza-thine
and penicillin G procaine. Other symptoms associated with this syndrome, such
as psychosis, seizures, dizziness, tinnitus, cyanosis, palpitations, tachycardia,
and/or abnormal perception in taste, also may occur.

DRUG INTERACTIONS

Tetracycline, a bacteriostatic antibiotic, may antagonize the bactericidal
effect of penicillin, and concurrent use of these drugs should be avoided.

Concurrent administration of penicillin and probenecid increases and prolongs
serum penicillin levels by decreasing the apparent volume of distribution and
slowing the rate of excretion by competitively inhibiting renal tubular secretion
of penicillin.

Last reviewed on RxList: 2/25/2009
This monograph has been modified to include the generic and brand name in many instances.