Setting

20 clinical centres in the US.

Patients

2763 postmenopausal women <80 years of age (mean age 67 y, 89% white) with established CAD but no previous venous thromboembolism
and who had not had a hysterectomy. Exclusion criteria were CAD event ≤6 months or hormone use ≤3 months before entry, venous
thromboembolism, breast cancer, endometrial cancer, uncontrolled hypertension, diabetes, or other fatal disease. Follow up
was …