DTI tractography in two steps: 1) BedpostX used to obtain first + second dyad vectors, 2) Diffusion Toolkit use for tractography using first and second vectors with FACT algorithm, maximum 50 degree turn angle
Harvard Oxford cortical/subcortical masks registered to subject DTI space, thresholded at 10%
Connectivity matrix generation with UCLA Multimodal Connectivity Package, excluding fibers less than 5mm
For paper, graph distance matrices were multiplied by average fiber length between regions

Funding Source:

Brain network local interconnectivity loss in aging APOE-4 allele carriers. JA Brown et al. (2011). PNAS. doi: http://dx.doi.org/10.1073/pnas.1109038108
This work was supported by National Institutes of Health National Research Service Award 1F31AG035438-01 (to J.A.B.); by National Institutes of Health Grants P01-AG025831, AG13308, P50 AG 16570, MH/AG58156, MH52453, AG10123, and M01-RR00865; by the Department of Energy (Contract DE-FC03-87-ER60615); by the General Clinical Research Centers Program; by the Fran and Ray Stark Foundation Fund for Alzheimer’s Disease Research; and by the Ahmanson Foundation.