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The abundance of a subtype of white blood cells in melanoma tumors can predict whether or not patients will respond to a form of cancer immunotherapy known as checkpoint blockade. [Press release from University of California, San Francisco discussing online prepublication in Journal of Clinical Investigation]
Press Release | Full Article

Researchers describe a novel reChIP-seq approach and tailored bioinformatic analysis tool, normR that allows for the sequential enrichment and detection of co-localizing DNA-associated proteins in an unbiased and genome-wide manner. [Nat Commun]
Full Article

Scientists report that macrophages and microglia within the glioma microenvironment produce CCL2, a chemokine that is critical for recruiting both CCR4+ regulatory T cells and CCR2+Ly-6C+ monocytic myeloid-derived suppressor cells in this disease setting. [Cancer Res]
Abstract

The authors review old and new data on the importance of tumor necrosis factor (TNF) produced by T cells and how TNF signaling via TNFR2 may directly impact alternate aspects of T cell biology. [Cytokine]
Abstract

Visit our
reviews
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the immune regulation research field.

Stony Brook Medicine and the Mount Sinai Health System announced that they are entering into an affiliation agreement that includes collaboration on research, academic programs and clinical care initiatives, effective immediately. The institutions launched the partnership to heighten academic and research synergies and to promote discovery, provide expanded clinical trials for both institutions, and achieve breakthroughs in understanding and treating disease. [Stony Brook Medicine]
Press Release

The European Medicines Agency (EMA) announced new recommendations for monitoring the safety of biologics and biosimilars. The guidance will take effect on August 16th 2016. [Regulatory Affairs Professionals Society]
Editorial | Guideline

Large genomic databases are indispensable for scientists looking for genetic variations associated with diseases. But they come with privacy risks for people who contribute their DNA. A 2013 study showed that hackers could use publicly available information on the Internet to identify people from their anonymized genomic data. [Nature News]
Editorial

British scientists say they’re relieved by a government promise to guarantee them funding for existing EU research projects, even after the country leaves the European Union. But the reassurance only partly allays concerns about Brexit’s effect on UK science. [Nature News]
Editorial

A new type of cancer drug developed at Johns Hopkins University in Baltimore, Maryland, but not yet tested in clinical trials may have triggered the deaths of three patients who were undergoing an alternative cancer treatment by a nonmedical practitioner in Germany. [ScienceInsider]
Editorial

Rejections for US patents related to personalized medicine have spiked after recent Supreme Court decisions tightened the rules for such claims, an analysis of more than 39,000 patent applications reveals. [Nature News]
Editorial