Topiramate for the treatment of cocaine addiction: a randomized clinical trial

Bankole A JohnsonDepartment of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville2now with Department of Psychiatry, University of Maryland School of Medicine, BaltimoreJAMA Psychiatry 70:1338-46. 2013

..Thus, testing chronically administered or higher doses, or both, of topiramate would be necessary to determine conclusively whether or not it can attenuate the positive subjective and reinforcing effects of methamphetamine...

Topiramate for the treatment of cocaine addiction: a randomized clinical trial

Bankole A JohnsonDepartment of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville2now with Department of Psychiatry, University of Maryland School of Medicine, BaltimoreJAMA Psychiatry 70:1338-46. 2013

..007). These findings reveal significant interactive effects among variants in SLC6A4-HTR3A-HTR3B affecting AD. Further studies are needed to confirm these findings and characterize the molecular mechanisms underlying these effects. ..

A preliminary randomized, double-blind, placebo-controlled study of the safety and efficacy of ondansetron in the treatment of cocaine dependence

..These findings should be viewed in light of the possibility that a less intensive cognitive behavioural therapy regimen might have yielded more positive results in this initial phase II trial exploring for the efficacy of ondansetron...

A survey of synthetic cannabinoid consumption by current cannabis users

..The more favorable cardiovascular profile of SR isradipine would, however, make it more appropriate as an investigational medication for the treatment of stimulant dependence and related neurovascular disorders...

Improvement of physical health and quality of life of alcohol-dependent individuals with topiramate treatment: US multisite randomized controlled trial