A simple, sensitive, accurate, precise, reproducible and cost effective stability indicating UV spectrophotometric method has been developed for quantitative determination of Atomoxetine hydrochloride in bulk and pharmaceutical formulations. The UV spectrum was scanned between 200 to 400 nm and 270.5 nm was selected as maximum wavelength for absorption. Beer's law was obeyed in the concentration range of 10-80 g/ml. Good accuracy (100.18-100.26%), precision (%RSD 0.997-0.995) were found, the method was successfully applied to the pharmaceutical dosage form containing the above-mentioned drug without any interference by the excipients. Results of the analysis were validated as per ICH guidelines. Forced degradation studies includes the effect of temperature, oxidation, photolysis and susceptibility to hydrolysis across a wide range of pH values, were carried out according to the ICH requirements which can be used for the routine and quality control analysis of Atomoxetine hydrochloride in raw material and pharmaceutical formulations.

A simple, fast and precise multicomponent mode analysis method has been developed for simultaneous determination of Paracetamol (PAR), Thiocolchicoside (THC) and Aceclofenac (ACE) in tablet formulation. The wavelengths selected for these drugs were 256nm, 258nm and 270nm for Paracetamol,...

A Simple, rapid, accurate, economical and reproducible spectrophotometric method has been developed for quantitative estimation of Iron in tablet. The method optimum conditions for the analysis of the drug were established. The wavelength maxima for Iron were found to be 540 nm and method obeys...

Two simple, rapid, accurate, precise, cost effective, and reproducible UV spectroscopic methods have been developed for the simultaneous estimation of atenolol and amlodipine besylate in bulk and combined tablet dosage form. The first method is based upon the simultaneous equation and second...

Fixed dose combination tablet containing Gabapentin & Methylcobalamin is widely used for peripheral neuropathy. A simple, economic & precise UV-Vis spectrophotometric method has been developed for the estimation of Gabapentin & Methylcobalamin in tablet dosage form. The estimation was based upon...

The objective of the current study was to develop a validated stability-indicating assay method (SIAM) for risperidone after subjecting it to forced decomposition under hydrolysis, oxidation, photolysis, and thermal stress conditions. The liquid chromatographic separation was achieved...

A stability-indicating high performance liquid chromatographic (HPLC) method was developed for the assay of Prulifloxacin in bulk and tablet dosage formulations. Isocratic separation was achieved on Nucleosil 100-5 C18 column (250mmÃ—4.6mm i.d.,5mm particle size) using a mobile phase of...