oxytocin

Could using a good quality moisturizer on a daily basis help to lower markers of inflammation (proinflammatory markers) and actually help reduce anxiety, panic, PTSD, phobias, social anxiety and other mental health symptoms, plus other chronic health conditions at the same time? Based on a new pilot study, I’m going out on a limb and saying this may well pan out to be true. And there is certainly no harm in making this a daily self-care routine until further research confirms this, certainly because of the other benefits of using a moisturizer.

Emollients are moisturizers that help keep the skin moist and supple by reducing water loss from the epidermis, the outer layer of the skin.

The study set out to mirror an animal study where skin problems in older/aged mice was tied to elevated markers of inflammation called cytokines. When epidermal function/skin health in the mice was improved, the circulating cytokine levels were reduced:

Changes in epidermal function and levels of three key, age‐related, plasma cytokines (IL‐1β, IL‐6 and TNFα) were measured at baseline and after treatment.

Circulating levels of proinflammatory cytokines in the body, IL‐1β, IL‐6 and TNFα, were higher in the older adults before the use of the emollient. After topical use, i.e, using the cream on their skin twice a day for 30 days:

The authors suggest larger clinical trials to confirm this connection between high levels of proinflammatory cytokines and chronic inflammatory disorders and to show how improving skin health by moisturizing may prevent chronic inflammatory disorders such as heart disease, type II diabetes, osteoporosis and Alzheimer’s disease in older adults.

Our skin starts to deteriorate around age 50 with changes to epidermal pH, hydration, and the permeability barrier, which keeps water in and bacteria and other potential pathogens out. A loss of moisture and breaks in the permeability barrier cause the skin to release inflammatory cytokines. Ordinarily, these cytokines help to repair defects in the barrier, but in aging skin the barrier can’t be fixed as easily, so the inflammatory signals continue to be released, eventually reaching the blood.

This article and the study authors are suggesting this is an issue to be addressed with older adults and with respect to the above chronic diseases, but there is enough research on the role of inflammation on anxiety and other mental health conditions at any age, that this study had me perk up and take notice. Also, if you’re young and not moisturizing or living in a dry climate or have other factors contributing to inflammation (more on that below), could this be happening too? I believe it’s highly likely.

The role of inflammation on anxiety and other mental health conditions

The ongoing inflammation affects neurotransmitters and makes antidepressants less effective:

Chronic exposure to increased inflammation is thought to drive changes in neurotransmitters and neurocircuits that lead to depressive symptoms and that may also interfere with or circumvent the efficacy of antidepressants.

Many approaches for reducing cytokines and inflammation

I do want to address the one statement in the emollient study where they say that “approaches that reduce circulating cytokines are not yet available.” There are, in fact, many approaches for reducing cytokines and inflammation.

In one study vitamin D supplementation improved mood, reduced anxiety and lowered markers of inflammation (CRP and IL-10) in female diabetics who had low levels of vitamin D.

In another study looking at anxiety in women with PCOS (polycystic ovary syndrome), probiotics and selenium improved their mental health and hormonal profiles, lowered markers of inflammation and reduced oxidative stress.

Of course, these factors may also play a role in anxiety and using a functional medicine and nutritional approach, you can reduce the inflammation and eliminate the anxiety/depression. It’s a matter of finding your root cause/s and addressing them.

Research is also finding that GABA, one of the main calming neurotransmitters, may also have a possible role in “neuroimmune interaction, being involved in the modulation of immune cell activity associated with different systemic and enteric inflammatory conditions.”

Low zinc and low vitamin B6 are also factors in inflammation, and addressing low levels reduces inflammation and eases anxiety such as pyroluria (a social anxiety condition) and low GABA and low serotonin anxiety because zinc and vitamin B6 are co-factors for making these brain chemicals.

The benefit of touch and a boost of oxytocin

I’d like to mention other benefits of using a daily moisturizer – the benefits of touch, massage and a boost of oxytocin:

Hand massage and therapeutic touch has been shown to decrease anxiety and make the elderly in a nursing home feel more comforted. If you’re a caregiver to a parent, make daily moisturizing part of your routine.

Touch increases the release of oxytocin improving well-being and may also have “applications in neuropsychiatric disorders especially those characterized by persistent fear, repetitive behavior, reduced trust and avoidance of social interactions.”

Adding skin moisturizing to your daily self-care routine

I feel very comfortable saying you now we have a new tool – daily skin moisturizing – to add to your toolbox to help lower your markers of inflammation and reduce anxiety, panic, PTSD, phobias and social anxiety. Let’s use everything at your disposal to heal and feel your absolute best.

It’s something most women (and a few men) are already doing, and this information can give you more reason to continue to do it.

It’s a lovely self-care routine if you’ve not been doing it for some time or have never regularly used a moisturizer. This information can be an incentive to add it back to your daily routine or start doing it.

The biggest problem I see with moisturizing is using toxic chemicals and less than ideal creams on your skin so I reached out to colleagues and my community on Facebook to get input on their favorite home-made and store-bought moisturizers:

Stay tuned for a new blog on favorite good quality store-bought moisturizers

In the meanwhile, feel free to share your favorites and what your moisturizing self-care routine is like, and if you get regular massages and use moisturizing creams with love ones. Simply comment below.

This 2014 study is one of my all-time favorite applications of tryptophan, an amino acid I use extensively with anxious clients. The goal of the study, Tryptophan promotes charitable donating, was to investigate the link between serotonin and charitable giving, something the authors consider to be “one of the most important elements of prosocial behavior.” They offer this quote by Molière:

Every good act is charity. A man’s true wealth hereafter is the good that he does in this world to his fellow.

In this study they tested whether charitable donating or giving can be promoted with the use of the amino acid tryptophan, the biochemical precursor of serotonin:

Participants were compared with respect to the amount of money they donated when given the opportunity to make a charitable donation.

Additional information about the study

Here is some additional information about the study, where the study group was given 800mg of tryptophan:

Thirty-two healthy international south European students (mean age = 21.8; 4 male, 28 female; mean Body Mass Index = 21.5, range 17.8–30.8) with no cardiac, hepatic, renal, neurological, or psychiatric disorders, personal or family history of depression, migraine and medication or drug use participated in the experiment.

Sixteen participants (2 male, 14 female) were exposed to an oral dose (powder) of 0.8 grams [which is 800mg] of tryptophan – which roughly corresponds to the amount of TRP contained in 3 eggs–and 16 (2 male, 14 female) to 0.8 grams of microcrystalline cellulose, a neutral placebo. These doses were always dissolved in 200 ml of orange juice.

The donating task was standardized, without the presence of an experimenter, and with a fixed amount of money in a fixed number of notes and coins:

…Participants were not informed beforehand that the donating task was part of the experiment. Donating behavior was measured by the amount of money the participant donated. After having received 10 Euros… for their participation in the study, participants were left alone and asked whether they were willing to donate part of their financial reward to charity. Four money boxes (Unicef, Amnesty International, Greenpeace, and World Wildlife Fund) had been positioned on the table.

Here are the results:

As expected, compared to a neutral placebo, [tryptophan] appears to increase the participants’ willingness to donate money to a charity.

The serotonin oxytocin connection

The authors mention the “functional and anatomical interactions between serotonergic and oxytocinergic systems” and that “it may be likely that the willingness to donate money to a charity is modulated by the effect that serotonin exerts on oxytocin levels.”

My perspectives

I always like to add my perspectives on studies like this so here goes. We know that because tryptophan boosts serotonin it’s going to improve mood and reduce anxiety, worrying and fears. When you feel better, lighter, happier and calmer you feel like anything is possible and I can see how this could translate to feeling more caring and wanting to be charitable.

The authors do mention how low serotonin is correlated with “antisocial behaviors such as social isolation and aggression.” Anger and irritability is also something we see when serotonin is low. Of course, these are also antisocial behaviors.

One additional comment is that with the work I do, the amino acids are used when you show signs of low serotonin such as anxiety or worry or depression or insomnia or afternoon/evening cravings. I use the trial-response method to determine if you’ll actually respond to tryptophan i.e. experience benefits and how much you will need to see those benefits. I starting dose is typically 500mg tryptophan and I have found the Lidtke brand to be the most effective. You can read more on tryptophan here.

Because of this I’m intrigued with this application of using tryptophan in healthy individuals. But I’d also be cautious based on what I’ve seen with clients who don’t need serotonin support and take tryptophan – they can feel too sleepy or even more sad or more anxious. This would be my hesitation in saying we should give everyone tryptophan in order to create a more charitable and giving society. I do however agree with the authors about the importance of a quality real whole foods diet with adequate quality animal protein, saying the study result:

supports the idea that the food we eat may act as a cognitive enhancer modulating the way we think and perceive the world and others.

The lead author, Professor Laura Steenbergen, works in the Cognitive Psychology Unit, Institute for Psychological Research and Leiden Institute for Brain and Cognition, Leiden University Leiden, Netherlands, as is doing some very interesting research with amino acids, cognitive enhancement and mood improvement. It’s really exciting!

We’d love to hear if you feel more charitable and giving when you take tryptophan or 5-HTP (since it also boosts serotonin)?

And if you feel more charitable and giving when you eat a quality real whole foods diet with adequate quality animal protein?

Dr. Lindsey Berkson’s fascinating interview on the Digestive Health Summit, hosted by Dr. Michael Murray, is all about the love hormone or oxytocin and the effects on digestion. The interview is called – How the Love Hormone is Critical for Gut Health.

Oyxtocin is not just a love hormone. It is also a helpful gut hormone. Dr. Berkson will clearly and easily explain the role of oxytocin in gut motility, sensation, tone of the muscular and nervous system layers, and even in the application for various gut issues from leaky gut to inflammatory bowel disease. You will also learn why nature intended oxytocin to be a care-taker of human health and how critical this hormone is in both genders throughout life. Historically oxytocin was regarded as a pregnancy and lactation hormone but you will now learn how it is even amazingly much more. She shares that the love hormone:

can be endocrine-disrupted by plastic, by Bisphenol A, by synthetic oxytocin given to a mother at birth i.e. Pitocin. I started using oxytocin in practice about 15 years ago as a hormonal Viagra and a rebooter, and I suddenly discovered that when I added it to the protocol of my inflammatory bowel disease patients, often people who were on Prednisone, methotrexate, on multiple meds, that could barely drag themselves out of bed, they were having many bowel movements a day, many of them were diarrhea-like and bloody; when I added oxytocin to them, usually within a few weeks we were able to get them off most of their meds and their health just came up incredibly.

There are oxytocin receptors all throughout the gut:

They’re in the esophagus. They’re in the stomach. They’re in the small intestine, the large intestine, they’re in the pancreas. They have a lot to do with the alpha and beta cells, with the release and maintenance of sugar. They’re in the liver; they have a lot to do with detoxification.

And oxytocin has also been shown to have an impact on constipation:

They have a double-blind, randomized trial in women with constipation and when they gave them oxytocin, they just delivered nasally because it first acts on the brain and then it has peripheral or distant actions. They had statistically significant normalization of bowel movements with oxytocin sprayed through the nose. How amazing is that?

I was so struck by how regular, satisfying intimacy was right up there with veggies and exercise [for longevity] and I was trying to figure out why, is it just the human contact? Well, one of the reasons was because both men and women become drenched in oxytocin and so nature takes care of your gut.

It’s a really fascinating interview with new information that is science-based. It is not to be missed!

What should a healthy menopause look like and what does an unhealthy hormonal imbalance leads? And what is the significance of insulin, cortisol, and oxytocin?

Dr. Brian Mowll, host of the upcoming Diabetes Summit, interviews Dr. Anna Cabeca on the topic of menopause and metabolic health. Dr. Anna is a board certified gynecologist and obstetrician as well as board certified in anti-aging and regenerative medicine. She is an expert in functional medicine and an expert in women’s health.

She starts with an overview of what menopause should look like and what an unhealthy hormonal imbalance leads to:

Hormonally, what does menopause look like? Yes, we’re going to age. And we’re going to have wrinkles and laugh lines and smile lines and things like that. But that’s awesome. We should be waking up rested, going to sleep on schedule without difficulty and have the sense of peace within us that we’ve become able to enjoy the life that we’ve worked so hard to create and also be able to educate, inspire, and instruct those around us and the generations that follow us. So those are the ideals in menopause.

However, with our environment and toxicities and unhealthy aging and unhealthy hormonal imbalance, what happens is we tend to get overweight, difficulty with weight loss. We tend to have increases in our blood sugar, increases of heart disease. What that feels like, too, is hot flashes, mood swings, itchy skin, night sweats and irritability. The monster within us can come out!

The next part of their discussion is fascinating and rather unexpected. Dr. Brian asks Dr. Anna about the main hormonal players in menopause and this is what she shares:

As a gynecologist, you would think the major players would be estrogen, progesterone, and even testosterone. However, the major players when it comes to a healthy menopause are insulin, cortisol, and oxytocin. I run menopause programs specifically to get these major hormones in balance. And then we can fine tune the minor hormones.

But unless we’re getting the concepts that relate to increasing our body’s ability to have insulin sensitivity and, regarding cortisol, to have reset our cortisol, our natural circadian rhythm, we’re not going to get hormonal balance at all. And we’ll continue to struggle with the inflammation, the weight gain, the mood swings, [the anxiety and insomnia], the night sweats….

Actually, insulin and cortisol have a bigger role than estrogen, progesterone, and testosterone although those are important and DHEA as well which I will replace very frequently. But insulin and cortisol are key to healthy menopause.

And so cortisol is our natural anti-inflammatory. But also, we know that when we excrete high spikes of cortisol, that’s going to affect glucose production. So whether cortisol is too high or too low, we’re going to have an issue with glucose production and metabolism and increasing hemoglobin A1c and inflammation. So from both those areas, we’re going affect our inflammatory pathways.

Dr. Anna also covers some of the following in the interview:

Issues she sees with ketogenic diets and eating low carbohydrate diets (this one is for women in particular – she feels it throws off our neurotransmitters)

Why to test for pH and how to do it

Simple ways to boost oxytocin

Nutritional support for the adrenals

As I mentioned above, these are a few snippets from the upcoming Diabetes Summit.

In case you’re thinking “I don’t have diabetes, I don’t need to tune in to this one”, or “I’m not menopausal” or “I’m a guy” here are few points to consider:

If you’re a woman and experience stress this would be applicable whether or not you have diabetes or are in menopause (addressing this could help prevent diabetes and make menopause a breeze)

If you’re a man and experience stress this topic is also relevant, whether or not you have diabetes – just remove the words “menopause” and “women” and focus on the information about insulin, cortisol and oxytocin

So do consider tuning in to this one and other interviews in the summit!

If you do have diabetes or pre-diabetes then tuning in to the summit is a must! According to a 2015 study, nearly half the US population had diabetes or pre-diabetes. Add to that all the Americans who are overweight, obese, or have insulin resistance and other blood sugar imbalances, that number likely climbs above 75%! Unfortunately it’s not just in the US. Diabetes has become a global epidemic, predicted to get much worse in the next 20 years.

Clearly we need to do something different. Change often starts with information and inspiration. Learning the root causes of the problem and real solutions to correct those causes can motivate action.

I’m really pleased to be a speaker on this summit too. I cover the anxiety diabetes connection and how GABA helps reduce anxiety and how research shows it’s a promising treatment for diabetes. Read more here.

We’re in the midst of season 4 of The Anxiety Summit www.theanxietysummit.com and here are wise words of wisdom from some of our amazing speakers on MS, oxytocin, red meat, marijuana, mercury and more.

If you have joined the summit and are loving it, this serves as a nice recap, a reminder if you missed a talk and inspiration to stay tuned in for some of the later interviews. And making sure you know that each speaker has a blog with snippets and many additional resources.

And if you’ve recently joined my community for the summit a VERY big welcome!

If you have not yet signed up I hope these wise words inspire you to join us!

And it all needs to happen this way Trudy. I had to get that disabled. I had to be on the verge of utter catastrophe to begin to feel the effects of cognitive decline to do all this work and then feel the effects of all this healing that happens when you provide a healthy habitat for the human ecosystem and all this repair happens. If this hadn’t of have happened I’d still be a conventional medicine doc thinking the latest drugs out of the New England Journal of Medicine were the way to go as opposed to seeing the gospel of food and sleep and movement and stress reduction.

The Pitocin/synthetic discussion oxytocin with Dr. Kurt Woeller was fascinating:

And there’s a theory … that the Pitocin, which is synthetic oxytocin, which is given to women who are not naturally going into labor, it’s meant to action speed labor up. Pitocin being synthetic oxytocin may short circuit in some susceptible kids the natural production of oxytocin, therefore slowing down or turning off those areas in the brain that are normally being developed at that time, with regards to socialization.

Dr. Tom O’Bryan’s explanation of the limited gluten sensitivity testing that most people have done:

what happens when people have one of those peptides that the immune system is fighting that’s not the 33 [alpha-gliadin] and you do a blood test for gluten sensitivity. If your doctor orders the common blood test for gluten sensitivity and it looks for alpha-gliadin and it comes back negative and your doctors says you’re fine eating wheat. See, here’s the blood test. Well you can get a false negative meaning it says there’s no problem when there really is because your body’s fighting other peptides of wheat.

Zinc is a mineral and minerals tend to be more absorbable in animal forms. I think a lot of people are very confused about meat and seafood and often intimidated and scared. And then we’ve had this message to go plant based and even vegan which is not a diet that is healthy for the brain.

Dr. Hyla Cass, integrative psychiatrist covers marijuana and anxiety later in the summit:

very often people who have been smoking marijuana for a while – when they go off it they go through serious withdrawal – anxiety, insomnia, feeling really very bad. Very much like we see in movies – we understand what it’s like getting off heroin when people go through withdrawal. Very similar, it really looks similar in appearance. Not everyone does that but common enough.

Dr. John Dempster, co-host of the Mental Wellness Summit discusses mercury as a neurotoxin in his interview later in the summit

So I kind of want to shed some light on some of these areas and how it can affect anxiety directly. One of the big areas is mercury itself is a neurotoxin. So how does that impact our biochemistry and our physiology? Well what it’s going to do it’s going to start to disrupt on an endocrine and a neurotransmitter level some of our pathways. And one of the big pathways is actually the glutamate connection and the glutamate pathway. And glutamate is something that’s known as an excitatory neurotransmitter and this is something that if we have too much of it or it’s not being reuptake properly in our synapses we start to exhibit different types of symptoms of anxiety. And of course that’s just one possible trigger for anxiety.

The functions of cholesterol and some of the many health consequences of low cholesterol

Fat malabsorption, and other causes of low cholesterol

Oxytocin: bonding, trust and social anxiety and why it can be low

The relationship between oxytocin and cholesterol and anxiety/depression

How to naturally raise low cholesterol and low oxytocin

Here are some gems from our interview:

As I mentioned in my practice, most of the kids that I test are anywhere between 110 to 120. Now to give you a reference point, the National Institutes of Health states that levels less than 160, with regards to cholesterol, increases the rate of cancer, increases the rate of mental health disorders and even early death in some studies. So that target zone we’re typically using is to try to get those total cholesterol levels at least above 160. I usually shoot for around 170/175 if possible. So in some of the kids the cholesterol levels come up with the Sonic Cholesterol, but not all. What was interesting when I first started using the Sonic Cholesterol in practice sometimes within a week to two weeks I would get reports back by parents of autistic kids that their kids were calmer; they were more focused; they were happier; and what was most interesting to me was that they actually had improved eye contact and many of them were just appearing to be more social. Now as you know in autism the social component is a big problem.

The Pitocin/synthetic oxytocin discussion was fascinating:

And there’s a theory Trudy, I don’t know if you’ve heard this that the Pitocin, which is synthetic oxytocin, which is given to women who are not naturally going into labor, it’s meant to action speed labor up. Pitocin being synthetic oxytocin may short circuit in some susceptible kids the natural production of oxytocin, therefore slowing down or turning off those areas in the brain that are normally being developed at that time, with regards to socialization. So essentially those nerve cells don’t reach their full potential in those areas of the brain. That’s at least a theory, but it seems to hold true if you look at the biochemistry. So one of the other effects then of oxytocin in all of us is what they call the love hormone or the bonding hormone is that it increases feelings of trust and harmony and pleasure in that it’s in involved in our ability to make connections with people on a one-on-one basis, not only through touch but facial expression recognition, voice emotional recognition.

Given the several activities mediated by both OT [oxytocin] and 5-HT [serotonin] , such a relationship might provide new perspectives and insights into psychiatric disorders and/or social relationship disturbances, as well as novel treatment strategies overcoming and/or integrating the serotonergic paradigm.