Perpetual adoration at the National Expiatory Temple of San Felipe de Jesus, Mexico City

The Blessed Sacrament may be received by Catholics who have undergone First Holy Communion (i.e., given by a priest or deacon or an Extraordinary Minister of Holy Communion and immediately consumed by the communicant) as part of the Liturgy of the Eucharist during Mass. Roman Catholics believe that the soul of the person receiving the Eucharist should be in a "state of grace", i.e., have no mortal sin in their soul at the time of communion (Matt 5:23-24).

The Blessed Sacrament can also be exposed (displayed) on an altar in a monstrance. Rites involving the exposure of the Blessed Sacrament include Benediction and eucharistic adoration. According to Catholic theology, the host, after the Rite of Consecration, is no longer bread, but the Body and Blood, Soul and Divinity of Christ, who is transubstantiatedin it. Catholics believe that Jesus is the sacrificial Lamb of God prefigured in the Old TestamentPassover. Unless the flesh of that passover sacrificial lamb was consumed, the members of the household would not be saved from death. As the Passover was the Old Covenant, so the Eucharist became the New Covenant. (Matt 26:26-28), (Mark 14:22-24), (Luke 22: 19-20), and (John 6:48-58)

Reception of the Blessed Sacrament in the Anglican Communion and other Anglican jurisdictions varies by province. Formerly, Confirmation was generally required as a precondition to reception, but many provinces now allow all the baptised to partake as long as they are in good standing with the Church and have previously received First Communion.

Devotions to the Blessed Sacrament vary. Individuals will genuflect or bow in the presence of the Blessed Sacrament, which may be reserved in a tabernacle or aumbry on, behind, or near the altar. Its presence is usually indicated by a lamp suspended over or placed near the tabernacle or aumbry. Except among Anglo-Catholics, the use of a monstrance is rare. This is in keeping with the Article XXV of the Thirty-Nine Articles that "the Sacraments were not ordained of Christ to be gazed upon, or to be carried about, but that we should duly use Them." Nonetheless, many parishes do have services of devotions to the Blessed Sacrament, in which a ciborium is removed from the tabernacle or aumbry and hymns, prayers, psalms, and sentences of devotion are sung or read. In some parishes, when the Blessed Sacrament is moved from the tabernacle (from a high altar to a chapel altar, for instance), sanctus bells are rung and all who are present kneel.

In most Lutheran churches, a person must have had catechetical training prior to a First Communion (or have received Confirmation in the Lutheran Church) to receive the Eucharist. Recently, more liberal churches allow all who are baptized to received it. Similar to the Anglican teaching, Lutherans are also taught to genuflect or bow in the presence of the Blessed Sacrament, which is normally located on an altar. In the Lutheran churches that still celebrate the Corpus Christi, like the Roman Catholic Church, a Monstrance is used to display the Blessed Sacrament during the Benediction.

Lutheranism has its roots mostly in German cultural area and therefore the terminology may often historically differ slightly from general English use. Therefore traditionally the English term "Blessed Sacrament" has been substituted by "Sacrament of the Altar", (lat. Sanctissimum Sacramentum Altaris) which is used in the same meaning in Luther's Small Catechism. Later due to Reformed influence "The Sacrament of the Altar" has often been wrongly and misguidedly used as the term of the Eucharistic liturgy.