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Question

Methods

Design:

randomised controlled trial (RCT).

Allocation:

unclear allocation concealment.

Blinding:

blinded (outcome assessors).

Follow-up period:

1 year.

Setting:

Kuopio University Hospital, Kuopio, Finland.

Patients:

81 patients 18–65 years of age (mean age 51 y, 65% men) who had a body mass index of 28–40 kg/m2 and an apnoea-hypopnoea index (AHI) of 5–15 events/hour. Exclusion criteria were active treatment for OSA, pregnancy, and chronic kidney, thyroid, or liver disease.

Intervention:

a VLCD (600–800 kcal/d) for 12 weeks plus intensive lifestyle counselling for 1 year (n = 40) or general oral and written …

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