Bank robber Seth Gecko and his unpredictably violent brother Richie are wanted by the FBI and Texas Rangers after a deadly bank heist. While on the run to Mexico, the brothers take a former pastor and his family hostage. Trying to use their RV to cross the border, the group finds trouble after detouring to a strip club that is populated by vampires. There, they fight until dawn to save their lives.

This series expands the storyline of the film, adding new characters and exploring the Mesoamerican mythology behind the creatures inside the club.