We agree with Drs. Zhang and Xu that long-term outcomes represent the most-awaited information from future studies comparing TAVI with SAVR. Indeed, our study sets long-term mortality as a secondary exploratory end point to refrain from overinterpretation, and our conclusions focus on early and midterm follow-up considerations. Drs. Zhang and Xu should note our statement that the effects of TAVI on long-term mortality remain unclear and may reflect the individual underlying risk and the TAVI approach used. Our review is transparent in reporting that only matched studies with significant heterogeneity related to study design drove the observed nonsignificant...