This request investigated the association between new typical antipsychotic use and stroke, with new atypical antipsychotic use as the comparison exposure. Data from January 1, 2001 to September 30, 2015 from 13 Data Partners contributing to the Sentinel Distributed Database (SSD) were included in this report. This request was distributed to Data Partners on March 10, 2017.

Report 1 (primary analysis): New typical antipsychotic use and stroke, with new atypical antipsychotic use as the comparison exposure

Report 2: New typical antipsychotic use and stroke, with new atypical antipsychotic use as the comparison exposure, using a risk window of 1 day to 15 days following exposure initiation

Report 3: New typical antipsychotic use and stroke, with new atypical antipsychotic use as the comparison exposure, using a risk window of 16 to 90 days following exposure initiation

Report 4: New haloperidol use and stroke, with new atypical antipsychotic use as the comparison exposure