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LC on the Edge

In 2015, we posed a provocative question: have we reached the limits of liquid chromatography? Our experts returned a resounding, “no!” Two years on – and timed to coincide with HPLC 2017 in Prague – we reach out to gurus old and new to ask: are we still pushing the limits?

Davy Guillarme
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05/16/2017

Testing Boundaries, By Davy GuillarmeNew Wave, By Koen SandraKeep Pushing, By Fabrice GrittiUp the (R)Evolution!By Gert DesmetThrough the Maze, By Monika Dittmann2D-LC Has Arrived, By James Jorgenson

Testing Boundaries

Complex biological samples demand a new generation of LC systems

A major breakthrough in LC over the past 10 years has been the commercialization of modern chromatographic systems able to work at pressures up to 1,000–1,500 bar, with low extra-column volume and dwell volume. In parallel, new columns packed with sub 2 μm fully porous particles and sub 3 µm superficially porous particles entered the market. Together, these two innovations have led to a resurgence of interest in HPLC.

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