Prof. Dr. Otto Wolfgang Ort-Meyer is the creator and one of the five fathers of Agent 47, he is a discredited German scientist living in Romania, Ort-Meyer's radical theories were deemed insane by his peers. Dr. Ort-Meyer served in the French Foreign Legion with the other four fathers of 47, after leaving he ran a mental institution, which he used as a cover for genetic experiments.

In exchange for research funding, Ort-Meyer provided his former comrades with donor organs harvested from clone bodies, which significantly extended their longevity. (By the events of Hitman: Codename 47, each of Ort-Meyer's accomplices were well into their 60-70s, but appeared 10–20 years younger.)

Ort-Meyer believed that genetic recombination and human cloning could be used to produce a perfected version of the human species, superior in strength and mind and unburdened by conscience. His ultimate goal (unknown to his associates) was to create an army of flawless and unquestioningly obedient supermen.

When Ort-Meyer's associates become suspicious of his motives, he employed 47 to systematically eliminate each of them. However his plans backfire when 47 discovers the truth, 47 then manages to eradicate the last line of clones and Ort-Meyer's himself.