Choline on the Brain? A Guide to Choline in Chronic Fatigue Syndromehttp://phoenixrising.me/research-2/the-brain-in-chronic-fatigue-syndrome-mecfs/choline-on-the-brain-a-guide-to-choline-in-chronic-fatigue-syndrome-by-cort-johnson-aug-2005
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Great Plains organic acids test interpretation

Does anyone know how to interpret an organic acids test? I'm not sure which parts are most relevant, but some things seem off, like
- very high Uracil
- slightly high Succinic, hippuric, arabinose
- high HVA/VMA
- low ascorbic
- high glutaric
- slightly low pyridoxic

It's strange that if I take B6 I get muscle twitches and burning hands (B6 toxicity symptoms) shortly after. B2 doesn't have any dramatic effect on me, so I don't know about the high glutaric.

I also don't seem to tolerate Aspirin/salicylates. I got very dizzy and have developed increased thirst and visible/enlarged blood vessels after taking it.

Here is a presentation about interpretation of that test, here is an interpretation of a slightly different test but covering most of the same markers and here is an interpretation of dysbiosis markers.

The high uracil markers indicates functional folate deficiency.

High succinate could mean several things but you should view it in light of your other Kreb's cycle markers. These are all low or very low. ATP production is very inefficient. Also the low pyruvate marker shows that glycolysis is also low - your main energy pathways are functioning poorly.

High glutaric can mean functional B2 deficiency while low ascorbate and pyridoxic can mean low intake of vit C and B6 respectively.

High HVA/VMA may mean an imbalance in neurotransmitter production/use.

Hippuric and arabinose are dysbiosis markers. Hippurate can be influenced by diet as well as gut bacteria so a mildly elevated value in isolation may not mean much.

GPL alone claim that arabinose is a fungal marker. There is nothing published about this and I am not sure that I believe it is specific to fungi. Again a mildly elevated value in isolation may not mean much.

I think you have a potential problem in your oxalate markers. Glycolic in particular is quite high.

Here is a presentation about interpretation of that test, here is an interpretation of a slightly different test but covering most of the same markers and here is an interpretation of dysbiosis markers.

The high uracil markers indicates functional folate deficiency.

High succinate could mean several things but you should view it in light of your other Kreb's cycle markers. These are all low or very low. ATP production is very inefficient. Also the low pyruvate marker shows that glycolysis is also low - your main energy pathways are functioning poorly.

High glutaric can mean functional B2 deficiency while low ascorbate and pyridoxic can mean low intake of vit C and B6 respectively.

High HVA/VMA may mean an imbalance in neurotransmitter production/use.

Hippuric and arabinose are dysbiosis markers. Hippurate can be influenced by diet as well as gut bacteria so a mildly elevated value in isolation may not mean much.

GPL alone claim that arabinose is a fungal marker. There is nothing published about this and I am not sure that I believe it is specific to fungi. Again a mildly elevated value in isolation may not mean much.

I think you have a potential problem in your oxalate markers. Glycolic in particular is quite high.

They mention a patient that had this SNP and had a low functioning PFKM, but I'm not sure... it's not too clear. Maybe it could explain the lower pyruvate...

I tried supplementing with R5P (10mg) for the B2 for a few days but I didn't feel any better. And I've started taking 1000mcg 5-MTHF.

It feels like my body just doesn't heal very well. If I get a new injury from some test, then it just piles on top of the rest. Maybe the B9 is important for healing injured tissue since I see it's used in the U -> T conversion.

Supplementing with calcium ascorbate somehow also makes me very thirsty, so I don't know...

I'm going to get a rT3 test in a few weeks and see if there's something there that is holding me down.