Tag: cancer cause

In March, 2015, 17 experts from 11 countries met at the International Agency for Research on Cancer (IARC; Lyon, France) to assess the carcinogenicity of the organophosphate pesticides tetrachlorvinphos, parathion, malathion, diazinon, and glyphosate (table). These assessments will be published as volume 112 of the IARC Monographs.

Glyphosate is a broad-spectrum herbicide, currently with the highest production volumes of all herbicides. It is used in more than 750 different products for agriculture, forestry, urban, and home applications. Its use has increased sharply with the development of genetically modified glyphosate-resistant crop varieties. Glyphosate has been detected in air during spraying, in water, and in food. There was limited evidence in humans for the carcinogenicity of glyphosate. Case-control studies of occupational exposure in the USA, Canada and Sweden reported increased risks for non-Hodgkin lymphoma that persisted after adjustment for other pesticides. The AHS cohort did not show a significantly increased risk of non-Hodgkin lymphoma. In male CD-1 mice, glyphosate induced a positive trend in the incidence of a rare tumour,renal tubule carcinoma. A second study reported a positive trend for haemangiosarcoma in male mice. Glyphosate increased pancreatic islet-cell adenoma in male rats in two studies. A glyphosate formulation promoted skin tumours in an initiation-promotion study in mice.

Glyphosate has been detected in the blood and urine of agricultural workers, indicating absorption. Soil microbes degrade glyphosate to aminomethylphosphoric acid (AMPA). Blood AMPA detection after poisonings suggests intestinal microbial metabolism in humans. Glyphosate and glyphosate formulations induced DNA and chromosomal damage in mammals, and in human and animal cells in vitro. One study reported increases in blood markers of chromosomal damage (micronuclei) in residents of several communities after spraying of glyphosate formulations. Bacterial mutagenesis tests were negative. Glyphosate, glyphosate formulations, and AMPA induced oxidative stress in rodents and in vitro. The Working Group classified glyphosate as “probably carcinogenic to humans” (Group 2A).

As many as 31 pesticides with a value running into billions of pounds could have been banned because of potential health risks, if a blocked EU paper on hormone-mimicking chemicals had been acted upon, the Guardian has learned.

The science paper, seen by the Guardian, recommends ways of identifying and categorising the endocrine-disrupting chemicals (EDCs) that scientists link to a rise in foetal abnormalities, genital mutations, infertility, and adverse health effects ranging from cancer to IQ loss.

Commission sources say that the paper was buried by top EU officials under pressure from big chemical firms which use EDCs in toiletries, plastics and cosmetics, despite an annual health cost that studies peg at hundreds of millions of euros.

The unpublished EU paper says that the risks associated with exposure to even low-potency EDCs is so great that potency alone should not serve as a basis for chemicals being approved for use. Its proposed criteria for categorisations of EDCs – along with a strategy for implementing them – was supposed to have enabled EU bans of hazardous substances to take place last year.

But commission officials say that under pressure from major chemical industry players, such as Bayer and BASF, the criteria were blocked. In their place, less stringent options emerged, along with a plan for an impact assessment that is not expected to be finalised until 2016.

“We were ready to go with the criteria and a strategy proposal as well but we we were told to forget about it by the secretary general’s office,” a commission source told the Guardian. “Effectively the criteria were suppressed. We allowed the biocides and pesticides legislation to roll over.”Continue reading “Suppressed EU Report Could Have Banned 31 Pesticides”