Historians of science generally consider that Darwinism has played an important part in the birth of scientific ecology. Now most 19th century seminal works of the new discipline have been elaborated within a Lamarckian framework. The source of this paradox lies in the double-content of the adaptation concept, considered as a static phenomenon by the ecologists and as a dynamic process by the evolutionists. Although closely related nowadays, as shown by modern evolutionary ecology, the problematics of the fields of research (...) at issue were initially separated. (shrink)

The purpose of this paper is to demonstrate that Pascal understood God and Reason to be part of a continuum, comprehensible to the understanding, and not radically opposed to one another. The paper situates Pascal in the context of seventeenth-century intellectual history and examines the concept of Dieu Caché from the perspective of seventeenth-century linguistics.

Within Descartes' philosophy, the problem of the Eucharist provides scholars the occasion to investigate a nexus of questions belonging to different domains of his thought. In taking up this problem, about which there has been much written in the past few decades , I hope first of all to discern some order in the texts themselves, as well also as in their various interpretations, and then, from there, to propose a new perspective.

New concepts may prove necessary to profit from the avalanche of sequence data on the genome, transcriptome, proteome and interactome and to relate this information to cell physiology. Here, we focus on the concept of large activity-based structures, or hyperstructures, in which a variety of types of molecules are brought together to perform a function. We review the evidence for the existence of hyperstructures responsible for the initiation of DNA replication, the sequestration of newly replicated origins of replication, cell division (...) and for metabolism. The processes responsible for hyperstructure formation include changes in enzyme affinities due to metabolite-induction, lipid-protein affinities, elevated local concentrations of proteins and their binding sites on DNA and RNA, and transertion. Experimental techniques exist that can be used to study hyperstructures and we review some of the ones less familiar to biologists. Finally, we speculate on how a variety of in silico approaches involving cellular automata and multi-agent systems could be combined to develop new concepts in the form of an Integrated cell (I-cell) which would undergo selection for growth and survival in a world of artificial microbiology. (shrink)

There is a popular view that Descartes and Pascal were antagonists. I argue instead that Pascal was a Cartesian, in the manner of other Cartesians in the seventeenth century. That does not, of course, mean that Pascal accepted everything Descartes asserted, given that there were Cartesian atomists, for example, when Descartes was a plenist and anti-atomist. Pascal himself was a vacuuist and thus in opposition to Descartes in that respect, but he did accept some of the more distinctive and controversial (...) aspects of Cartesianism, including his mechanistic philosophy and the consequent view that animals are automata. (shrink)

The idea that beliefs may be stake-sensitive is explored. This is the idea that the strength with which a single, persistent belief is held may vary and depend upon what the believer takes to be at stake. The stakes in question are tied to the truth of the belief—not, as in Pascal’s wager and other cases, to the belief’s presence. Categorical beliefs and degrees of belief are considered; both kinds of account typically exclude the idea and treat belief as stake-invariant (...) , though an exception is briefly described. The role of the assumption of stake-invariance in familiar accounts of degrees of belief is also discussed, and morals are drawn concerning finite and countable Dutch book arguments. (shrink)

Recent scholarship has shown that the success of Pascal’s wager rests on precarious grounds. To avoid notorious problems, it must appeal to considerations such as what probability we assign to the existence of various gods and what religion we think provides the greatest happiness in this life. Rational judgments concerning these matters are subject to change over time. Some claim that the wager therefore cannot support a steadfast commitment to God. I argue that this conclusion does not follow. By drawing (...) upon the line of reasoning employed in getting married, I explain how unstable considerations can provide a sufficient rational foundation for a stable commitment. (shrink)

Among recent objections to Pascal’s Wager, two are especially compelling. The first is that decision theory, and specifically the requirement of maximizing expected utility, is incompatible with infinite utility values. The second is that even if infinite utility values are admitted, the argument of the Wager is invalid provided that we allow mixed strategies. Furthermore, Hájek (Philosophical Review 112, 2003) has shown that reformulations of Pascal’s Wager that address these criticisms inevitably lead to arguments that are philosophically unsatisfying and historically (...) unfaithful. Both the objections and Hájek’s philosophical worries disappear, however, if we represent our preferences using relative utilities (generalized utility ratios) rather than a one-place utility function. Relative utilities provide a conservative way to make sense of infinite value that preserves the familiar equation of rationality with the maximization of expected utility. They also provide a means of investigating a broader class of problems related to the Wager. (shrink)