Subject is naïve to antiretroviral treatment (subjects may not have more than 7 days of any antiretroviral treatment).

Subject is at least 18 years of age, inclusive.

If female, subject is either not of childbearing potential, defined as postmenopausal for at least 1 year or surgically sterile (bilateral tubal ligation, bilateral oophorectomy or hysterectomy), or is of childbearing potential and practicing one of the following methods of birth control:condoms, sponge, foams, jellies, diaphragm or intrauterine device(IUD), a vasectomized partner, total abstinence from sexual intercourse

If female, the results of a urine pregnancy test performed at screening (urine specimen obtained no earlier than 28 days prior to study drug administration) is negative.

Subject has no significant history of cardiac, renal, neurologic, psychiatric, oncologic, endocrinologic, metabolic or hepatic disease that would in the opinion of the investigator adversely affect his/her participating in this study.

Subject does not require and agrees not to take any of the following medications for the duration of the study: midazolam, triazolam, terfenadine, astemizole, cisapride, pimozide, propafenone, flecainide, certain ergot derivatives (ergotamine, dihydroergotamine, ergonovine, and methylergonovine), rifampin, lovastatin, simvastatin, and St. John's wort.

Subject agrees not to take any medication during the study, including over-the-counter medicine, alcohol or recreational drugs without the knowledge and permission of the principal investigator.

Subject has not been treated for an active AIDS-defining opportunistic infection within 30 days of screening.

Subject has a plasma HIV RNA level of greater than 400 copies/mL at screening.

Subject agrees to take all doses of the study drug from the bottles provided by the sponsor (rather than other containers, i.e., "pill box").

Subject has voluntarily signed and dated an informed consent form, approved by an Institutional Review Board (IRB)/Independent Ethics Committee (IEC), after the nature of the study has been explained and the subject has had the opportunity to ask questions. The informed consent must be signed before any study-specific procedures are performed.

Exclusion Criteria:

Subject has a history of an allergic reaction or significant sensitivity to LPV/r, INV or Combivir.

Subject has a history of substance abuse or psychiatric illness that could preclude adherence with the protocol.

Screening laboratory analyses show any of the following abnormal laboratory results:

Hemoglobin ≤ 10.0 g/dL

Absolute neutrophil count ≤ 1000 cells/µL

Platelet count ≤ 50,000 per mL

ALT or AST ≥ 3.0 x Upper Limit of Normal (ULN)

Creatinine ≥ 1.5 x Upper Limit of Normal (ULN)

Subject has received any investigational drug within 30 days prior to study drug administration.

For any reason, subject is considered by the investigator to be an unsuitable candidate for the study.

Contacts and Locations

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study.
To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below.
For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00043953