Impact of the genome on the epigenome is manifested in DNA methylation patterns of imprinted regions in monozygotic and dizygotic twins.

Even in monozygotic twins, a benchmark for assessing genetic risk in non-Mendelian
disease, discordance is significant. This study showed that while DNA methylation states are tightly maintained between genetically identical individuals, there remains considerable epigenetic variation that may contribute to disease susceptibility.

This Recommendation is of an article referenced in an [http://f1000.com/prime/reports/b/4/18/...

To read the rest of this recommendation and access
over 145,000 article recommendations from 3,700+ journals across biomedicine, register
for a month’s FREE TRIAL and create your
personalized F1000Prime homepage.

Institutional Subscriptions

Send a recommendation to your institution's librarian or
information manager to request an extended free trial for all users at your institution.

What is F1000Prime?

Over 145,000 recommendations of top articles in biology and medicine, contributed by the F1000 Faculty.

Covering more than 3,700 peer-reviewed journals and updated daily, the data are easily navigated by subject area or advanced search.

Unique tools allow creation of highly personalized article feeds and alerts to provide users with the most relevant and up-to-date content from F1000Prime and PubMed too.

The Faculty

The F1000 Faculty selects, rates, and reviews articles they consider worthy of inclusion in F1000Prime to help you filter the mass of biomedical literature.

It comprises more than 5,000 expert scientists and clinical researchers nominated by their peers, and includesNobel Laureates, Lasker Award winners and Fellows of the Royal Society.

Customize F1000Prime

Personalized homepage: for quick access to the most relevant F1000Prime article recommendations, plus relevant articles as soon as they are published.