The Cherokee Nation’s secretary of state, Chuck Hoskin Jr., released a blistering statement Monday in response to the test showing Warren was between 1/64th and 1/1,024th Native American:

“A DNA test is useless to determine tribal citizenship. Current DNA tests do not even distinguish whether a person’s ancestors were indigenous to North or South America. Sovereign tribal nations set their own legal requirements for citizenship, and while DNA tests can be used to determine lineage, such as paternity to an individual, it is not evidence for tribal affiliation. Using a DNA test to lay claim to any connection to the Cherokee Nation or any tribal nation, even vaguely, is inappropriate and wrong. It makes a mockery out of DNA tests and its legitimate uses while also dishonoring legitimate tribal governments and their citizens, whose ancestors are well documented and whose heritage is proven. Senator Warren is undermining tribal interests with her continued claims of tribal heritage.”

Trump played up the statement in a tweet Tuesday morning:

Thank you to the Cherokee Nation for revealing that Elizabeth Warren, sometimes referred to as Pocahontas, is a complete and total Fraud!

However you feel about Trump’s rhetoric or Warren’s claims, the rebuke is a significant political moment. This is the very nation to which Warren claims a connection saying that she is “undermining tribal interests with her continued claims of tribal heritage.” They’re effectively saying her claims and efforts to prove her heritage are no longer helpful and even harmful. Individual Native Americans have denounced Warren before; now the Cherokee Nation has taken a pretty firm stand against her, thanks to the DNA test.

And just as important as the tone of the statement is its trajectory — something of a reversal of course for the Nation, which back in 2012 declined to criticize Warren and even defended her.

The nation did rebuke one candidate in that 2012 race, but it was then-Sen. Scott Brown (R-Mass.) rather than Warren. After Brown staffers and supporters were caught on camera making war whoop chants and doing the tomahawk chop, Baker took issue with Brown’s lackluster response.

“The Cherokee Nation is disappointed in and denounces the disrespectful actions of staffers and supporters of Massachusetts Sen. Scott Brown,” Baker said. “The use of stereotypical ‘war whoop chants’ and ‘tomahawk chops’ are offensive and downright racist. It is those types of actions that perpetuate negative stereotypes and continue to minimize and degrade all native peoples.”

“. . . I call upon Sen. Brown to apologize for the offensive actions of his staff and their uneducated, unenlightened and racist portrayal of native peoples.”

It’s one thing for Warren to lend some credence and proof to her ancestry claim; it’s another for that claim to be judged sufficient for Warren to use it in a professional setting. The Cherokee Nation’s statement and the reactions of other Native Americans suggest they’re unwilling to accept the latter.