In other people’s presence I was, as formerly, deferential and quiet; any other line of conduct being uncalled for: it was only in the evening conferences I thus thwarted and afflicted him.

Both the sisters seemed struck: not shocked or appalled; the tidings appeared in their eyes rather momentous than afflicting.

She told me one evening, when more disposed to be communicative than usual, that John’s conduct, and the threatened ruin of the family, had been a source of profound affliction to her: but she had now, she said, settled her mind, and formed her resolution.

I asked of God, at once in anguish and humility, if I had not been long enough desolate, afflicted, tormented; and might not soon taste bliss and peace once more.

There are no more uses of "afflict" in the book.

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She is afflicted by diabetes.

While taking the test, she was afflicted with a toothache and a throbbing head.