Webinars:

Exosomes encapsulate and transport a wide variety of molecules generated by their cell-of-origin, a process now thought to be a form of cellular signaling. Exosome signaling is common across cell types and species, but it is of particular interest in diseases with an inflammatory component. While exosome isolation and analysis is useful to understanding the mechanisms behind these multifaceted diseases, exosomes may also be exploited for their therapeutic potential. The Scientist is bringing together a panel of experts to review the current knowledge on exosomes in inflammation, and to explore the potential for exosome-based therapeutics. Attendees will have the opportunity to interact with the experts, ask questions, and seek advice on topics that are related to their research.

Topics to be covered:

The exosomal cargoes released during inflammation, and their potential as therapeutic targets

Bioprocess Insights Webinars

The biopharmaceutical industry has developed into a multi-billion dollar market in just 30 years. Making decisions and setting up strategies in a rapidly changing environment can be challenging. The difference between a good and a great decision can have extensive implications for the future of a company. In this environment, knowledge and experience are what make the difference. Good insights about, for example, technical advancements, process economy implications, and sustainability aspects can help improve the individual decisions and strengthen the overall business strategy.

In this webinar series, four renowned subject matter experts will share their insights into four areas of bioprocessing: upstream, vaccines, downstream, and single-use technology. We will present tangible, recently developed data that can help you in developing modern, cost-efficient, and sustainable bioprocesses.

Abstract: Optimizing protein production by CHO cells grown in serum free conditions is an ongoing process, requiring a balance between cell proliferation and protein production. Many tools are utilized to increase protein titers, like metabolomics, media optimization and continuous perfusion. We investigated the use of a novel lipid supplement to improve media conditions using various strategies to increase protein yield. One strategy of adding the lipid supplement at the initiation of culture resulted in an increase in monoclonal (mAb) titer of 30% from CHO cells without increasing viable cell density (VCD). Furthermore when the metabolic profile was examined there were no differences in any of the metabolites tested, including ammonia, glutamate, lactate, glucose and others. A second strategy of using the supplement in a fed batch process as a feed resulted in two notable effects. The first effect was increasing the titer yield by close to 25%. The second effect was extending the window for peak protein production from 1 day to 2 days. The supplement was also used in a single use bioreactor. The lipid supplement used as a feed in a Wave bioreactor resulting in an increase of 27% of mAb titer. This research using this lipid supplement is the first to show an increased titer in a single use bioreactor. These results show there are opportunities for further optimization of protein production using lipids. Furthermore some of the standard metrics like metabolic profiles may not be able to predict improved titer or productivity. It is possible the use of lipids alters energy utilization for de novo membrane formation and improves the energy efficiency for protein production as evidenced by the scalable small bioreactor results.

TIDES Europe – November 14-17, 2016 – Berlin, Germany – http://get.knect365.com/tides-europe/TIDES Europe is the place where oligo and peptide experts go to meet and build successful partnerships to accelerate products from early discovery through late stage development and commercialisation. In 2015 Tides Europe attracted a 40% increase in attendance across the oligo and peptide audience.

The World Precision Medicine Congress USA is bringing together big pharma, big data, and healthcare providers to discuss the scientific, economic, and policy goals towards producing precise and genomic-based medicines. Partnered with forward-looking industry leaders such as precisionFDA and NantWorks, this event will fast-track our momentum into the future paradigm of healthcare by spurring the important discussions to get us there.

Can you afford to miss this gathering of precision medicine leaders? Pharma, big data, and healthcare providers will be there attending sessions on gene therapy, cell therapy, personalized medicine, and genomics.

Headlines:

“The young surgeon was mystified. A fist-size tumor had been removed from the stomach of his patient 12 years earlier, but his doctors had not been able to cut out many smaller growths in his liver. The cancer should have killed him, yet here he lay on the table for a routine gallbladder operation.”

“The U.S. Department of Health and Human Services has shifted $81 million in funds from other projects to continue work on developing vaccines to fight Zika in the absence of any funding from U.S. lawmakers.”

“Vedanta Biosciences has partnered with the NYU Langone Medical Center to develop microbiome-derived immunotherapies specifically for use paired with checkpoint inhibitors. The idea is to use the microbiome to help improve the efficacy of this major developing class of oncology drugs as well as, potentially, for standalone use to treat cancer.”

“Eleven Biotherapeutics granted Hoffmann-La Roche an exclusive, worldwide license to develop and commercialize EBI-031 and all other interleukin-6 (IL-6) antagonist antibody technology owned by Eleven. EBI-031 is a humanized monoclonal antibody that binds IL-6 and inhibits all known forms of IL-6 cytokine signaling, according to Eleven Biotherapeutics.”