The ED50 as determined by the dose-dependent proliferation of murine D10S cells is < 0.005 ng/ml, corresponding to a specific activity of > 2 x 108 units/mg.

Species Reactivity

Mouse, Rat

Buffer

PBS

Reconstitution

Reconstitute in0.5X PBS to a concentration of 0.1-1.0mg/mL.

Synonyms

Il1a; IL-1 alpha

Description

IL-1α is a non-secreted proinflammatory cytokine produced in a variety of cells including monocytes, tissue macrophages, keratinocytes and other epithelial cells. Both IL-1α and IL-1β binds to the same receptor and has similar if not identical biological properties. These cytokines have a broad range of activities including, stimulation of thymocyte proliferation, by inducing IL-2 release, B-cell maturation and proliferation, mitogenic FGF-like activity and the ability to stimulate the release of prostaglandin and collagenase from synovial cells. However, whereas IL-1β is a secreted cytokine, IL-1α is predominantly a cell-associated cytokine. Recombinant rat IL-1α is a 17.7 kDa protein containing 155 amino