..Thus, both TGFbeta2 and TGFbeta3 appear necessary for the full morphogenetic program of EMT in the chick, but only TGFbeta2 is expressed and obligatory for mammalian endocardial cushion cell transformation...

TGFβ2-mediated production of hyaluronan is important for the induction of epicardial cell differentiation and invasion

Evisabel A CraigDepartment of Pharmacology and Toxicology, The University of Arizona, Tucson, AZ 85721, USAExp Cell Res 316:3397-405. 2010

..This is an important and novel mechanism showing how TGFβ2 and HA signals are integrated to regulate changes in epicardial cell behavior...

Involvement of the MEKK1 signaling pathway in the regulation of epicardial cell behavior by hyaluronan

Evisabel A CraigDepartment of Pharmacology and Toxicology, The University of Arizona, Tucson, Arizona, USACell Signal 22:968-76. 2010

..Together, these findings suggest an important role for HA in the regulation of epicardial cell fate via activation of MEKK1 signaling cascades...

James J SollomeThe Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, AZ 85721, USACell Signal 26:70-82. 2014

..Cell migration is required for cancer cell metastasis, which is the major cause of cancer patient mortality. We identify MTK1 in the HER2/HER3-HRG mediated extracellular acidification and cell migration pathway in breast cancer cells. ..

..Thus, the activity of MEKK3 is sufficient for developmental EMT in the heart. This knowledge provides a basis to understand how MEKK3 integrates signaling cascades activating endocardial cushion EMT...

..Thus, in contrast to many genes expressed in the heart forming region, regulation of Has2 in the cardiogenic mesoderm is independent of Bmp signaling...

MEKK4 regulates developmental EMT in the embryonic heart

Mark V StevensDepartment of Pharmacology and Toxicology, College of Pharmacy, The University of Arizona, Tucson, Arizona, USADev Dyn 235:2761-70. 2006

..Thus, the kinase activity of MEKK4 is essential, but not sufficient, to support developmental EMT. This knowledge provides a basis to understand how MEKK4 may integrate signaling cascades controlling heart development...

Arsenite activates NFκB through induction of C-reactive protein

Ingrid L DruweDepartment of Pharmacology and Toxicology, The University of Arizona College of Pharmacy, Tucson, AZ 85721, USAToxicol Appl Pharmacol 261:263-70. 2012