My InterpretationTo me the song is about either a sexual relationship you'd really be better off without, or about a drug addiction.

The "said you were my friend" is the illusion of being in control, "why do you slap me in the face" is being hurt, despite thinking one was in control (and not saying it was OK), and in the end, realization that nothing is going to change or be helped, and resigning to that it just "really eats you up".

"You made a fool of me again and again and again..." could be about feeling stupid to have ended up in bed with this person again, or about doing stupid things while high.
"You violate a part of me again and again..." Both a destructive relationship and a drug habit violates parts of you; your sensibilities if nothing else.
"Extending part of me again and again..." The final (slightly delayed) surrender, simply put either getting a hardon or extending the arm to shoot up, admitting that this will keep happening again and again and again.

My InterpretationAll I know is the last verse has to do with Laynes longtime girlfriend. She died from bacterial endocarditis in the mid 90s (infection of the heart valve normally from IV drug use)
"Hey, Your weak will won't help her heal her heart
Hey, I'll bet it really eats you up"

His weak will, his addiction, helped kill her and it ate him up. This is one of their later songs, I'm guessing after she died?

@Tainted703 This song was written in 95 and Demri died in 96 but I think she was already ill (she spent the last 9 months of her life in a hospital). I think you're right, this song is about her too! I also think it has something to do with psychiatry because of the video!

General Commentanother confusing song. i dont think its about rape, even tho the way he sings it make him sound like hes being raped or tourtured or something. i think it is about AIC and how the media betrayed them. another one of my favorites

Part I:
Party 1 attacks Party 2 for lack of ability to stand up. Hence, "You let them do it again." Party 1 feels betrayed by Party 2, "You said you were my friend." This implies a trusting relationship in which one person did not live up to another's standards. Party 1 feels ashamed, and betrayed, that he trusted or put his faith and credit in Party 2 AGAIN.

Part II:
Party 2 tries but lacks the ability to assert himself in the face of something, whatever he (or she) has befallen several times before. "I made the same mistake." He AGAIN pledges himself to hold his commitment. "I won't do it again." When Party 1 says "I thought you were my friend" Party 2 feels his trust in Party 1 is violated. Party 1 understands Party 2's struggle, sees it for what it is, understands Party 2's commitment to Party 1, but would use the nature of their relationship against Party 2 to hurt him emotionally.

Part Three: Summation
First part is resolved when he thinks about it.
Second part is continued by acknowledgment of his weak will, and resignation to be an ineffective weak willed person.
Last line: Continuing the fight. Party 2 approaches Party I, Party I takes the offensive in saying Party 2 will be unable to comfort her. He adds insult to injury by saying "I bet it really eats you up." He may also be saying that he understands Party 2's plight in his inability to comfort her. Last line leaves it hanging a little, but as far as I'm concerned he really rubbing Party 2's nose in it.

I believe it's about an abusive relationship. Someone is being abused over and over again but it may be physical or verbal abuse. The point is to be vague so that it speaks to whom ever is experiencing the actual events or anything similar to them. Remember the individual makes up the true meaning of the song. What does it mean to them? What does it mean to you?

General CommentI'm not really sure about the rape, i mean if it was a rape, would it
be repetetive? ("You made a fool out' me again, again again
again again again again again and again...") I think this is a
relationship between two people (most likely a marriage) where one
side is constantly being mistreated in a way or another. Just my
opinion. Anyway, it's one of my favourite songs of all. The extremely
unique rhytmical pattern intertwined with spectacular, let's say, word
play along with perfect harmony between the two here clearly show how
incredible creative Jerry is and Layne was, and how well the band
understood eachother.