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In 1981‚ the Life Extension Foundation introduced DHEA (dehydroepiandrosterone) to its members through an article that described the multiple benefits this hormone might produce. However‚ the general public did not learn about DHEA until 1996‚ when its benefits were touted by the news media and in several popular books. DHEA became credible to the medical establishment when the New York Academy of Sciences published a book called DHEA and Aging. That book presented scientific validation of many life-extending effects of DHEA.

It has been shown that the serum hormone DHEA often declines by 75%–80% from peak levels by age 70‚ leading to hormonal imbalances that can affect one’s quality of life.1-3 Peak blood levels of DHEA occur at approximately age 25‚ decreasing progressively thereafter. The marked decline in serum DHEA with age is believed to play a role in health problems associated with aging. Thus‚ scientists have been looking at ways of restoring DHEA to youthful levels to prevent or reverse those health issues‚ and are now discovering mechanisms by which DHEA protects against age-related decline.

Since 1981‚ several thousand studies have been published on DHEA’s various benefits‚ including immunomodulatory properties as well as positive effects on mood‚ quality of life‚ and body composition. It has been proposed that restoring the circulating levels of DHEA to those found in young people may improve well-being and sexual function. In a randomized‚ double-blind‚ placebo-controlled study‚ ten months of DHEA replacement therapy showed a beneficial effect of enhancing the increases in muscle mass and strength with the addition of resistance exercise in elderly individuals. The studies of DHEA therapy in women with adrenal insufficiency also suggest beneficial effects on well-being‚ mood‚ and sexuality.5 DHEA could be of benefit to the normal aging brain. Some studies have reported DHEA may improve mood and alleviate melancholy.9 In addition‚ recent studies have shown that DHEA has the capacity to improve endothelial function by a number of complex processes. One of them is increasing nitric oxide synthesis.

In a randomized‚ double-blind‚ controlled trial‚ DHEA replacement therapy for one year helped protect hip bone mineral density in older adults and spine bone mineral density in older women. DHEA has also been shown to support a healthy circulatory system and joint/bone health.

DHEA usage and safety precautionsLife Extension has been investigating DHEA for almost 30 years. Life Extension’s DHEA directions for use are specially drafted to provide optimal‚ but safe dosing.

The standard blood test to evaluate DHEA status is one that measures DHEA sulfate levels (dehydroepiandrosterone sulfate or DHEA-S). The DHEA-S is calculated in micrograms per deciliter (µg/dL) of blood. A DHEA-S blood test may be taken three to six weeks after initiating a DHEA supplementation regimen to help determine optimal dosing. When having your blood tested for DHEA-S‚ blood should be drawn three to four hours after the last dose. DHEA testing may save you money if it shows you can take less DHEA to maintain youthful DHEA serum levels.

Because of the overwhelming evidence connecting low levels of DHEA to problems associated with aging‚ Life Extension suggests that all people over age 40 begin DHEA therapy. For most people‚ the starting dose of DHEA is between 15–75 mg‚ taken in one daily dose. Many studies have used a daily dose of 50 mg.

Since almost everyone over age 35–40 has lower than optimal levels of DHEA‚ most people begin supplementation and then test their blood DHEA levels later to make sure they are taking the proper dose. People over age 40 who do not supplement with DHEA usually have serum levels well below optimal since a steady decline takes place after the third decade in life.

Warning: DHEA and other steroid hormone precursors are not for use by individuals under the age of 18 years. Do not use if pregnant or nursing. Consult a physician or licensed qualified health care professional before using this product if you have‚ or have a family history of breast cancer‚ prostate cancer‚ prostate enlargement‚ heart disease‚ low “good” cholesterol (HDL)‚ or if you are using any other dietary supplement‚ prescription drug‚ or over-the-counter drug. Do not exceed recommended serving. Exceeding recommended serving may cause serious adverse health effects. Possible side effects include acne‚ hair loss‚ hair growth on the face (in women)‚ aggressiveness‚ irritability‚ and increased levels of estrogen. Discontinue use and call a physician or licensed qualified health care professional immediately if you experience rapid heartbeat‚ dizziness‚ blurred vision‚ or other similar symptoms. Keep out of reach of children. Do not purchase if outer seal is broken or damaged. To report a serious adverse event or obtain product information‚ call 1-800-332-1088.

There are different precautions for men and women that should be observed.

DHEA precautions for menBefore attempting to restore DHEA to youthful levels‚ men should know their serum PSA (prostate specific antigen) level. Men with prostate cancer or severe benign prostate disease are advised to avoid DHEA since it can be converted into testosterone (and estrogen). Therefore‚ men are advised to have a PSA and digital rectal exam before initiating DHEA to rule out existing prostate disease.

When taking DHEA we also recommend taking the following other nutrients daily:

Vitamin D 5‚000 – 10‚000 IUVitamin E (D-tocopheryl succinate) 400 IUSelenium 200 mcgGamma E Tocopherol with Sesame Lignans 200 mgLycopene Extract 10 – 40 mgBoron 3 – 10 mgCruciferous Vegetable Extracts 500 – 1000 mgIt is important for men over 40 to have a physician check their PSA and DHEA-S serum levels every six to twelve months thereafter. Men should also periodically check their blood levels for free testosterone and estrogen to make sure that DHEA is following a youthful metabolic pathway.

See the Male Hormone Modulation chapter in the Disease Prevention & Treatment book for additional hormone balance testing that can be done at the same time serum DHEA and PSA levels are being tested.

DHEA precautions for womenWomen should consider estrogen and testosterone testing when they take their DHEA blood test in order to evaluate DHEA’s effect on their blood levels of these hormones.

Women who have been diagnosed with an estrogen-dependent cancer should consult their physicians before beginning the DHEA restoration process.

When taking DHEA we also recommend taking the following other nutrients to maintain a healthy balance each day:

This supplement should be taken in conjunction with a healthy diet and regular exercise program. Results may vary.

These statements have not been evaluated by the Food and Drug Administration (FDA). These products are not meant to diagnose‚ treat or cure any disease or medical condition. Please consult your doctor before starting any exercise or nutritional supplement program or before using these or any product during pregnancy or if you have a serious medical condition.

If you have any general questions regarding orders or our policies and programs, please contact our Customer Happiness Team @ 1.800.383.6008

If you are pregnant, nursing, taking any medications or have any medical condition, consult your doctor before use. Your healthcare professional is the best source for guidance before beginning an exercise or nutritional supplement program.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.