Cpressin-P® Injection

Cpressin-P® Injection is an antidiuretic medication used to prevent and manage postoperative abdominal distention, dispel interfering gas shadows during roentgenography, in diabetes insipidus and abdominal radiography. Cpressin-P® Injection is for subcutaneous or intramuscular (IM) use. Suitable for individuals from 6 to 65 years of age.

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Cpressin-P® Injection is an antidiuretic medication used to prevent and manage postoperative abdominal distention, dispel interfering gas shadows during roentgenography, in diabetes insipidus and abdominal radiography. Cpressin-P® Injection is for subcutaneous or intramuscular (IM) use. Suitable for individuals from 6 to 65 years of age.

Active Ingredient

Description

Cpressin-P® Injection is manufactured by Samarth Life Sciences. This is a sterile solution for subcutaneous or intramuscular injections. It acts by making the kidneys produce less urine whilst increasing its concentration. The active substance of Cpressin-P® Injection is Vasopressin, a synthetic polypeptide hormone, analog of the natural antidiuretic hormone (ADH).

Indications:

- cranial diabetes insipidus followed by abnormal production of urine (polyuria) and constant thirst (polydipsia). Do not confuse with diabetes mellitus (sugar diabetes);

- prevention/treatment of postoperative abdominal distention;

- dispelling of interfering gas shadows in abdominal roentgenography.

Cpressin-P® Injection is also used to increase blood pressure in adults with vasodilatory shock (e. g. post-cardiotomy, sepsis) whose blood pressure has remained low after receiving fluids and other medicines.

MOA (mechanism of action):

Vasopressin acts through V1 and V2 receptors, that control the activity of blood vessels and kidneys respectively. Therefore, Vasopressin modulates the vasoconstriction and fluid reabsorption processes. Namely, it acts on renal collecting ducts increasing water permeability, which leads to decrease in urine formation and increase in blood volume instead.

Dosage

Cpressin-P® Injection is given into a muscle (intramuscularly-IM) or under the skin (subcutaneously).

Do not take Cpressin-P® Injection intravenously.

The solution should be used immediately after the ampoule was open.

The maximum daily dose for adults is 0,75 ml (15 units).

Taking 1 or 2 glasses of water at the time of Cpressin-P® Injection administration will alleviate side effects such as blanching of skin, abdominal cramps, and nausea.

Following subcutaneous or intramuscular administration of Cpressin-P® Injection, the duration of antidiuretic activity is usually maintained for 2 to 8 hours.

Children over 6 years: the pediatric dosage, as well as course duration, must be determined by a doctor for each individual patient.

Abdominal roentgenography:

The accurate single dose must be determined by a doctor.

The average recommended dose is 2 injections of 0,5 ml (10 units) each. The injections should be given 2 hours and 30 minutes respectively before the roentgenography procedure.

Diabetes Insipidus:

The accurate dosage, as well as course duration, must be determined by a doctor for each individual patient.

The average recommended dose varies from 0,25 to 0,5 ml (5-10 units) 2-3 times daily.

Where to give subcutaneous injection:

1. Abdomen: at or under the level of the belly button.

2. Arm: back or side of the upper arm (slightly underneath the shoulder).

3. Thigh: front of the thigh. Divide your thigh into 3 equal parts. A third in the middle will be right for injection.

How to give subcutaneous injection:

1. Wash your hands with soap.

2. Choose the area to be injected. Make sure the skin there is not broken or inflamed.

3. Sanitize the injection site with an alcohol cotton wool. Let it dry.

4. Place the syringe between your thumb and first finger. Let the syringe lean on your second finger.

5. With your free hand, grasp the skin at the injection site.

6. Hold the syringe tightly and carefully insert the needle into the skin. Once the needle is all the way in, push the plunger down to inject the medicine.

7. After you have injected the solution, remove the needle at the same angle you put it in. Gently wipe the area with the gauze pad.

8. Dispose of syringe safely. Wash your hands.

Where to give intramuscular (IM) injection:

1. Thigh. Divide your thigh into 3 equal parts. A third in the middle will be right for injection.

2. Hip. Place the palm of your hand on the upper, outer part of the thigh, where the buttocks meet. Point your thumb at the groin and fingers toward the patient's head. Make a V with fingers, whilst separating the first finger from the other three. With the tips of little and ring fingers, you will feel the edge of a bone. The area to give the injection is in the middle of the V.

3. Upper arm muscle. The upper arm should be completely exposed. The injection is given in the middle of an upside down triangle. The bone going across the top of the upper arm is a part of the scapula, called acromion process. The bottom of it forms the base of the triangle. The point of the triangle is below the center of the base nearly the armpit. The suitable area to give an injection is in the middle of the triangle, 2,5 to 5,1 cm below the acromion process. The hip should not be used if the person is very thin or the muscle is too small.

4. Buttocks. Expose one side of the buttocks. Draw a line from the top of the crack between the buttocks to the side of the body with an alcohol wipe. Find the middle of that line and go up 7,6 cm. From this point, draw another line down and across the first line, ending about halfway down the buttock. You should have drawn a cross. There will be a curved bone in the upper outer square. The injection will be given into the upper outer square below the curved bone.

How to give intramuscular (IM) injection:

1. Wash your hands.

2. Choose the area to be injected. Make sure the skin there is not broken or inflamed.

3. Sanitize the injection site with an alcohol cotton wool. Let it dry.

4. Place the syringe between your thumb and first finger. Let the syringe lean on your second finger.

5. With your free hand, gently press on and pull the skin so that it is tight a little bit.

6. Hold the syringe tightly and use your wrist to inject the needle into the skin and into the muscle at an angle 90 degrees.

7. Stop holding the skin with your other hand. Keep the syringe pointed straight in. Aspirate a little to make sure you did not hit a blood vessel. If blood comes, remove the needle immediately. Do not inject the medication. Dispose of both the syringe and the medicine. Get more medication in a new syringe. When you give the second injection, give it on the other side.

8. Insert the medication by pushing on the plunger. Inject the medication slowly to reduce the pain.

Missing a dose

If you miss a dose you should inject it as soon as you remember about your missing. If it is time for the next dose you should continue your regular dosing schedule. Do not inject a double dose.

Overdose

Do not exceed the doctor's recommended dose. The symptoms of Cpressin-P® Injection overdose may include confusion, drowsiness, continuing headache, nausea or vomiting, rapid weight gain, and convulsions in severe cases. If any of these occurs and you are feeling unwell, you should seek emergency medical attention or contact your healthcare provider immediately.

Storage

Store at a room temperature from 20 to 25 degrees C (68 to 77 degrees F) away from moisture and heat. Throw away the tube after the expiration date. Keep away from children.

Safety Information

Side effects

The most common side effects associated with the use of Cpressin-P® Injection are:

tremor

sweating

vertigo

circumoral pallor

“pounding” (pulse) in head

abdominal cramps

passage of gas

nausea and vomiting

urticaria

bronchial constriction

arrhythmias

decreased cardiac output

angina

myocardial ischaemia

peripheral vasoconstriction

gangrene

rhabdomyolysis

Side effects occurrence does not only depend on the medication you are taking, but also on your overall health and other factors.

Contraindications

Do not take Cpressin-P® Injection if you are allergic to Vasopressin or Desmopressin.

Do not take Cpressin-P® Injection if you are allergic to any of the other ingredients comprised in Cpressin-P® Injection.

Do not combine Cpressin-P® Injection with the use of diuretics.

Do not take Cpressin-P® Injection if you have fluid imbalance in the body, vascular disease, epilepsy, migraine, asthma, toxaemia of pregnancy, nephritis, arterial hypertension, goitre with cardiac complications, coronary thrombosis, angina pectoris, arteriosclerosis or any state in which a rapid addition to extracellular water may produce hazard for an already overburdened system.