Neuro steroidogenesis

Pituitary surgery is the primary treatment modality for most sellar masses (other than prolactinomas). The transsphenoidal route is preferred in patients with lesions accessible via this approach, as it is associated with less morbidity than craniotomy. In patients with sellar masses, indications for surgery include the presence of mass effect (compression of the optic apparatus leading to visual field defects, diplopia, suspected pituitary apoplexy), hormone excess other than prolactin, sellar mass growth (even in asymptomatic patients), and the need to establish a tissue diagnosis.

Steroid isolation , depending on context, is the isolation of chemical matter required for chemical structure elucidation, derivitzation or degradation chemistry, biological testing, and other research needs (generally milligrams to grams, but often more [38] or the isolation of "analytical quantities" of the substance of interest (where the focus is on identifying and quantifying the substance (for example, in biological tissue or fluid). The amount isolated depends on the analytical method, but is generally less than one microgram. [39] [ page needed ] The methods of isolation to achieve the two scales of product are distinct, but include extraction , precipitation, adsorption , chromatography , and crystallization . In both cases, the isolated substance is purified to chemical homogeneity; combined separation and analytical methods, such as LC-MS , are chosen to be "orthogonal"—achieving their separations based on distinct modes of interaction between substance and isolating matrix—to detect a single species in the pure sample. Structure determination refers to the methods to determine the chemical structure of an isolated pure steroid, using an evolving array of chemical and physical methods which have included NMR and small-molecule crystallography . [2] : 10–19 Methods of analysis overlap both of the above areas, emphasizing analytical methods to determining if a steroid is present in a mixture and determining its quantity. [39]

Considering, that hair generation is an energy (read mitochondrial) intense process, sudden hair loss could be an early marker that mitochondrial resources are limited and being reallocated towards more critical operations like brain and heart functioning. When the components for proper mitochondrial functioning are absent, be it the thyroid hormones or the co-factors necessary for cellular energy (ATP) production, the first wave of resource allocation might be to cease non-essential activities. The non-essential activities would include hair growth (and wakefulness in general – read Medication and Vaccine Adverse Reactions and the Orexin – Hypocretin Neurons ). Sudden or unexplained hair loss could indicate mitochondrial impairment. Back date the hair loss 2-4 weeks and an illness, a medication, vaccine or environmental exposure could be the culprit. Whatever the cause, the thyroid mitochondrial health should be considered and treatment initiated accordingly, because if the disease process continues , the symptoms will expand beyond the hair, potentially to every tissue and organ in the body. Concurrently, investigate and amend nutritional status. Mitochondrial functioning is critically dependent on proper nutrients. Deficits in important nutrients, like thiamine can have severe repercussions .