a N-terminal F-BAR (Bin, Amphiphysin, Rvs) domain involved in membrane deformation, and FCH domain; F-BAR displays faster molecular dynamics than F-BAR(SRGAP3) and F-BAR(SRGAP1) at the plasma membrane, which correlates well with its increased potency to induce filopodia

a FBH and a HR1 doamains

a central Rho-GAP domain which specifically stimulates the GTPase activity of RAC1

is associated with synaptic membranes and is detected in the postsynaptic density

basic FUNCTION

axon guidance and neurite outgrowth

couplingmembrane deformation to actin cytoskeleton reorganization in various cellular processes

controls cortical neuron migration

SRGAP, SRGAP2, SRGAP3 are not only involved in the regulation of the Slit-Robo signal transduction, but also in neuronal development and that the translocation of srGAPs is important for their functions

negatively regulates neuronal migration and induces neurite outgrowth and branching through the ability of its F-BAR domain to induce filopodia-like membrane protrusions resembling those induced by I-BAR domains

regulates neuronal morphogenesis through the ability of its F-BAR domain to regulate membrane deformation and induce filopodia formation