The Gist: Following Donald Trump's resounding victory in the Indiana primary, Sen. Elizabeth Warren (R-MA) railed against the presumptive Republican presidential nominee in a series of tweets, noting he has "built his campaign on racism, sexism, and xenophobia."

The Gist: After a Trump drubbing, the party could very well be in the exact same position it found itself in in 2008 and 2012, re-litigating a core question: Is the GOP losing because its candidates aren't conservative enough -- or because it's banking on a narrow, white constituency that is being eclipsed by a growing minority population?

From The Reporter's Notebook

TPM's Tierney Sneed examined why Republicans' reaction to Donald Trump will be different than when Barry Goldwater was their nominee. Geoff Kabaservice, author of “Rule and Ruin: The Downfall of Moderation and the Destruction of the Republican Party, From Eisenhower to the Tea Party,” explained that in 2016, due to gerrymandering, it will be the moderate Republicans that are most likely to lose their seats, rather than the conservatives who were voted out in the 1964 election. “The problem is the most conservative members of Congress in the House tend to be the one with the most secure seats,” Kabaservice said. “So what you could have is a situation that is actually the reverse of ‘64. ‘64 was a big chastising moment for the Republican party. You ended up with a Congress that was moderate on the Republican side than in the preceding congress."

Agree or Disagree?

Josh Marshall: "It is striking how similar the denouements of Cruz's and Rubio's campaigns ended up being. Sure they both lost. But the biggest embarrassments, unforced dignity losses, came at their own hands, actions they took in desperation in an failing effort to overcome Trump."

Say What?!

"We’ve already had people testing this, going into Targets and men trying to go into bathrooms. There is absolutely no barrier."

From a TPM Prime member: "In my search for a counter to Trump's isolationist rhetoric I downloaded a fascinating book "Connectography: Mapping the Future of Global Civilization" by Parag Khannan after seeing him on with Fareed Zakaria Sunday. He makes a convincing case that supply and demand is more than an economic market principle for determining the price of goods, it's been a dynamic force in development of humankind since early recorded history. Civilizations have organized themselves along supply chains like rivers and sea ports for access to trade. Infrastructure like roads, bridges, canals, pipelines and Internet POPs are arteries that carry the life's blood of civilizations in the form of natural resources, goods and services, data and ideas. Connectivity is key, retrenchment should be avoided and barriers, including walls and wars, eliminated. Another thing I've learned from the book even though I haven't finished reading it yet - ASEAN countries represent approximately one-fifth of the global economy and they see the United States as a hedge against China. China, in a form of neo-mercantilism, is currently building infrastructure (~2000 kilometers of railway so far) in Africa like crazy. Hopefully Africa will take advantage of it."."