Murray SG et al. – The results suggest that the presence of antiphospholipid antibodies (aPL), hypertension, and stroke are key variables associated with cognitive impairment, which may aid in identification of patients at greatest risk.

Methods

Subjects included 694 participants from the Lupus Outcomes Study (LOS), a longitudinal study of SLE outcomes based on annual telephone survey querying demographic and clinical variables.

In additional analyses evaluating the association between these predictors and severity of cognitive impairment, stroke was significantly more prevalent in participants with severe impairment when compared to those with mild or moderate impairment (p=0.036).