We have succeeded to record a-wave, b-wave and oscillatory potentials (OPs) in human macular region, using the focal amcular ERG recording system developed by us. The analysis of these components can provide the layr-by-layr diagnosis of the macular diseases. The purpose of this study is to investigate the pathogenesis of the diabetic maculopathy with this system. Before analylzing diabetic maculopathy, we studied the inner layr disease (congenital retinoschisis and aphakic cystoid macular edema) and outer retinal disease (central serous chorioretinopathy) to know the properties of focal macular ERG in theses known diseases. The results indicated that in outer retinal disease, all components of ERG were deteriorated, even when the visual acuity was relatively good. On the othger hand, in inner retinal diseases, the OPs were the most sensitively deteriorated, followed by the deteriration of the b-wave and a-wave. In diabetic macular edema, the focal macular ERG showed combined onner and outer retinal layr disturbance in many patients, indicating that the edema excists not only in the inner retinal layr, but also in the outer retinal layr.今年度は糖尿病黄斑浮腫の黄斑部局所ERGを検討した。糖尿病黄斑浮腫の初期には律動様小波のみの減弱を示す場合もみられたが多くの症例ではa波を含む全要素に著しい減弱がみられ糖尿病黄斑浮腫の病態が網膜血管のbarrierの破壊による(inner retinal barrier)黄斑部網膜内層のみに浮腫が限局しておらず網膜外層にも浮腫が波及していることが暗示された。この外層障害は網膜色素上皮のbarrierの破壊の結果(outer retinal barrier)とも考えられた。a波にも異常が生じた糖尿病黄斑浮腫に対して光凝固や硝子体手術を施行したところ浮腫が減退し視力の向上をみた症例もあったが黄斑部局所ERGの回復はほとんどみられなかった。他の原因により生じた黄斑部浮腫に比べて糖尿病黄斑浮腫は電気反応から判定した場合重症度が高く治療によってもその回復は限定されることが判明した。