Acta-Resveratrol

Antioxidant

Helps maintain a healthy heart

Promotes normal cell development

Mimics the longevity effects of calorie restriction

DISCUSSION: Resveratrol is a polyphenolic compound found in various berries (cranberry, blueberry, grapes) and herbs. Acta-Resveratrol provides antioxidants and other factors for the maintenance of good health.

AOR Guarantees:
that no ingredients not listed on the label have been added to the
product. Contains no wheat, gluten, corn, peanuts, sulphites, mustard,
eggs, dairy, soy, fish, shellfish or any animal byproduct.

Adult Dosage: Take 1 capsule daily with food or as directed by a qualified health care practitioner.

Cautions:
Consult a health care practitioner for use beyond 6 weeks, and/or if
you are taking phenytoin. Some people may experience headaches.

Research

Background Information

Resveratrol
is a naturally occurring polyphenolic compound found in various berries
(cranberry, blueberry, grapes), peanuts, rhubarb and a number of
oriental herbs including the Japanese Giant Knotweed (Polygunum
cuspidatum).

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There
is no doubt that many among us, in the context of dinner-party banter
or some other setting conducive to the transfer of anecdotal wisdom,
have heard that a glass of wine a day is good for your health. ‘A
healthy heart and a long life’ is usually the jist of this particular
nugget of scientifically secular populist enlightenment. The long life
that is inferred is attributable to a substance that the scientifically
observant elite have identified as resveratrol, a phytonutrient
originating -in this case – in the vinyards. Resveratrol, in turn,
elicits this wondrous effect largely by mimicking many of the biological
chain of events seen in the practice of Calorie Restriction Optimum
Nutrition (CRON), or simply Caloric Restriction (CR).

Caloric
Restriction (CR) is the only proven method of increasing life span in
numerous and diverse species, from yeast, worms, fruit flies, spiders,
rodents, all the way up to primates. Calorie restriction refers to an
approximately 40% reduction in caloric intake, usually accompanied by a
maintenance level of nutrients. The institutions that have conducted
this research include Cornell and Harvard University, as well as the
prestigious Massachusetts Institute of Technology (MIT) – testimony to
the credibility behind Caloric Restriction. This research has branched
out to encompass the study of ‘caloric restriction mimetics’. These are
compounds that enable organisms to parallel many of the beneficial
biological effects of a caloric restriction diet, and among the most
prominent of these is a substance known as resveratrol.

We are
reminded of the ‘one glass of wine a day for longer life’ anecdote. In
order to obtain the substance identified as responsible for this effect
in amounts that are commensurate with even the most conservative trials,
one needs to consume approximately 1,000 glasses of red wine each day! A
noble goal for some, but perhaps one capsule containing enough
resveratrol to equal that found in approximately 100 glasses of red wine
might be a more practical start.

Research

Studies
with resveratrol have reported a diverse range of physiological and
biochemical effects, particularly in the areas of heart health, cancer,
immunity and inflammation. Other beneficial cardiovascular effects
include the reduction of cholesterol and triglycerides, dilation of
blood vessels (hence a blood pressure lowering effect), platelets being
less “sticky” (anti-aggregatory effect) – and consequently a lower
incidence of atheroma or plaque formation and a reduced rate of strokes
and heart attacks. Resveratrol exerts anti-oxidant effects by quenching
free radicals (including reactive oxygen species) that act as cellular
terrorists, reducing the oxidation of LDL particles, which many believe
to be the initiating event in atherosclerosis or hardening of the
arteries. Resveratrol also inhibits unfavourable cellular proliferation
and up-regulates apoptosis or programmed cell death.

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Resveratrol
has been shown to down-regulate the production of chemicals (cytokines)
involved in the cause, signaling and amplification of inflammation.
Resveratrol’s anti-cancer effects have been shown to occur at all three
stages of cancer – initiation, promotion and progression. Prevention of
blood flow to the tumour (angiogenesis) restricting the growth and
spread of the cancer cells and inhibition of various enzymes involved
(e.g. cyclooxygenses or ornithine decarboxylase) have been attributed to
resveratrol. Finally, the modulation of the activity of the two groups
of enzymes – Phase 1 and Phase 2 – also plays an important role in the
detoxification and anti-cancer effects of resveratrol. The Phase 1
family of enzymes normally makes compounds more carcinogenic or toxic
and resveratrol has an inhibiting effect on them, thereby preventing
carcinogen formation. Alternatively, stimulation of the Phase 2 class of
enzymes help facilitate the removal of toxins and carcinogens from the
body by making these compounds even more soluble and easier for
excretion.

The plants that produce resveratrol do so as a response
to stressors such as fungal infection or ultra violet exposure.
Resveratrol has been shown to enhance life extension much like caloric
restriction in yeast (70%), worms (18%), fruit flies (30%), and fish
(60%). The mechanism may be similar to sirtuin activation. There is
considerable excitement regarding the use of resveratrol as a CR
Mimetic. A recent study published in the prestigious journal Nature
jointly by Harvard University and the National Institute of Aging
demonstrated that resveratrol in high doses offset the effects of an
unhealthy high-calorie diet in mice. Resveratrol is a molecule that
occurs in nature in two forms or as mirror-images, namely the trans and
cis forms. It is the trans version of the resveratrol that is the active
form that has been used in all the investigations. The cis form may be
at best inactive or at worst inhibit the activity of its mirror image –
the trans form. There are high quality, naturally extracted sources that
yield 98% plus trans activity.

Market Trends

In
recent times people have become more interested in the health benefits
that components in red wine can offer when consumed on a regular basis
and in a reasonable amount. Resveratrol is one of the more recent
fountain of youth discoveries.

AOR Advantage

This
formula contains several antioxidants that increase the overall
effectiveness of it; antioxidants function better in the body in
combination rather than when they are in isolation. Each capsule of
AOR’s Acta-Resveratrol contains enough resveratrol to equal that found
in approximately 180 glasses of red wine and without the negative side
effects of alcohol.