Hughes had two sacks and forced a fumble, and backup linebacker Jamie Blatnick recovered a fumble in the end zone for a touchdown. Hughes was starting in place of defensive end Mario Williams, who was held out after complaining of soreness following practice Wednesday.

Rookie quarterback EJ Manuel then took over in the second half to seal the win in continuing to inch his way toward securing the starting job after veteran Kevin Kolb struggled in the first half. Greeted by cheers as he took the field, Manuel hit all six attempts, including a four-yard touchdown pass to Brad Smith, to cap a 14-play, 80-yard second-half opening drive. The first-round draft pick out of Florida State was 10-for-12 for 92 yards in three series.

The Bills improved to 2-0 in the preseason under new coach Doug Marrone, following a 44-20 win at Indianapolis on Sunday.

The Vikings (0-2) again sputtered on offense without their top threat, Peterson, who continues to be rested in the preseason.

Ponder went 5-for-12 for 53 yards passing through five series. Backup Matt Cassel wasn't much better in a first half in which the Vikings combined for 74 yards of offense and four first downs.

Cassel finished 4-for-8 for 29 yards passing over four series spanning halftime.

49ers 15, Chiefs 13: Chiefs quarterback Alex Smith struggled against his former team, and backup San Francisco quarterback B.J. Daniels threw a late touchdown pass to give the 49ers a preseason victory. Phil Dawson hit all three of his field-goal attempts for the 49ers, two of them 55-yarders, while the Chiefs' Quintin Demps returned a kickoff 104 yards for a touchdown. Smith was just 7-for-16 for 62 yards while playing the full first half, but he did help Kansas City to two field goals. Colin Kaepernick, who took over Smith's starting job in San Francisco last season, only played the first offensive series. He threw a pair of passes with one completion for minus-3 yards.

Saints 28, Raiders 20: Drew Brees passed for 202 yards and a touchdown while leading five scoring drives, and the Saints survived a sloppy second half for a preseason victory. Brees' scoring strike was a 16-yarder to rookie Kenny Stills, who made the most of his second straight game playing with the first-team offense. Brees completed 78 percent of his passes (14-for-18), including a 56-yarder to Nick Toon, setting up Mark Ingram's two-yard TD run. New Orleans' new defense under coordinator Rob Ryan thrived, sacking Matt Flynn five times in the first half.