Cognitive dysphoria

Cognitive dysphoria (semantically the opposite of euphoria) is medically recognized as a cognitive and emotional state in which a person experiences intense feelings of dissatisfaction, and in some cases indifference to the world around them.[1] These feelings can vary in their intensity depending on the dosage consumed and the users susceptibility to mental instability. Although dysphoria is an effect,[2] the term is also used colloquially to define an intense state of general melancholic unhappiness combined with an overwhelming sense of discomfort and malaise.