Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision

12-January-2010 RFH

Synonyms

6-Methyl-1,3,8-trihydroxyanthraquinone

Description

A cell-permeable, reversible, substrate competitive and potent p56lck tyrosine kinase inhibitor (IC50 = 18.5 µM). Selectively blocks the growth of v-ras transformed human bronchial epithelial cells (IC50 = 14.8 µM) without affecting normal human bronchial epithelial cells, even at a concentration of 370 mM. Reported to act as an inhibitor of Tau aggregation and aid in the disassembly of PHF in vitro and in vivo.

Form

Orange solid

CAS number

518-82-1

RTECS

CB7920600

Chemical formula

C₁₅H₁₀O₅

Structure formula

Purity

≥90% by HPLC

Solubility

DMSO (1 mg/ml), Ethanol or Aqueous alkali

Storage

+2°C to +8°C

Do Not Freeze

Ok to freeze

Special Instructions

Following reconstitution in DMSO, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 3 months at -20°C. Unstable in aqueous alkali; reconstitute just prior to use.