Krasnoyarsk Krai is located in the remote geographical center of Russia along the great Siberian river, the Yenisey (the world's fifth largest by length and volume), and its tributaries. West of the Yenisey, Krasnoyarsk Krai begins the unending flat sea of taiga and tundra that ends with the Ural Mountains, while the majority of the Krai (to the east of the Yenisey) is covered by the beautiful mountainous wild of the Sayan Mountain Range and the Putoran Plateau. For the truly adventurous, wilderness travel in this region is limited only by safety concerns and imagination, as the Soviet government deliberately kept most of Krasnoyarsk Krai closed and devoid of human presence.

The southern Krasnoyarsk region is the heart of this vast area and its most visited region as it contains the city of Krasnoyarsk, the third largest in Siberia and is a major stop on the Trans-Siberian Railway.

The climate is strongly continental with wide variation of temperatures during the year. The climatic belts are three: arctic, subarctic and moderate. The average temperature of January in the north is −36 °C and −18 °C in the south. In July the temperatures are +10 °C and +20 °C accordingly.

There are a number of indigenous languages spoken throughout the region, including the interesting Siberian linguistic isolate Ket, but travelers are unlikely to hear them unless they specifically seek them out. Everyone without exception, however, speaks Russian.

The usual manner in which travelers arrive to Krasnoyarsk Krai is undoubtedly at the Krasnoyarsk stop on the Trans-Siberian Railway. If you are planning a trip specifically to the region, however, it will save a lot of time to fly directly to Krasnoyarsk airport (from Moscow, Saint Petersburg, Khabarovsk, Rostov-on-the-Don, or virtually any airport in Siberia) and then transfer to Kras-Air to go to other destinations within the region. For visitors to the northern parts of the region, there is a direct flight from Moscow to Khatanga and Norilsk (although this airport may be off limits to foreigners) in Taymyria as well as to Igarka in the northernmost part of Krasnoyarsk (region).

Because of the size and remoteness of the region, domestic flights combined with helicopter rides are often the best ways of getting around outside of the more populous southern region. Flights are most often connected to the Krasnoyarsk hub. To get straight into Evenkia, there is a flight from Krasnoyarsk to Tura.