Diagnosis[edit]

Cause[edit]

Prognosis[edit]

The prognosis of mixed connective tissue disease is in most cases worse than that of systemic lupus erythematosus (SLE) in spite of prednisone treatment as this disease is progressive and may in many cases evolve into a progressive systemic sclerosis (PSS), also referred to as diffuse cutaneous systemic scleroderma (dcSSc) which has a poor outcome. In some cases though the disease is mild and may only need aspirin as a treatment and may go into remission where no Anti-U1-RNP antibodies are detected, but that is rare or within 30% of cases.

Most deaths from MCTD are due to heart failure caused by Pulmonary Arterial Hypertension (PAH).