Raphael's Renaissance 'hood, the vibrant university town of Urbino is often the first stop on a trip to Le Marche and understandably so. The patriarch of the Montefeltro family, Duca Federico da Montefeltro, created the hippest art scene of the 15th century here, gathering the great artists, architects and scholars of his day to create a sort of think tank. The town's splendour was made official by Unesco, which deemed the entire city centre a World Heritage Site.