Publications

Marcela KrečmerováGilead Sciences and IOCB Research Centre, Centre for New Antivirals and Antineoplastics IOCB, Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech RepublicJ Med Chem 50:1069-77. 2007

Detail Information

Publications16

Marcela KrečmerováGilead Sciences and IOCB Research Centre, Centre for New Antivirals and Antineoplastics IOCB, Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech RepublicJ Med Chem 50:1069-77. 2007

..Decomposition of 1 in alkaline solutions resulted in products 17 and 18. While the N-formylguanidine derivative 17 proved active, the carbamyolguanidine derivative 18 was devoid of antiviral activity...

..Although the primary task of hypomethylating agents in anticancer therapy lies in reactivation of silenced tumour-suppressor genes, the inhibition of hTERT expression might also be a fruitful clinical effect of this approach...

N(4)-Acyl derivatives as lipophilic prodrugs of cidofovir and its 5-azacytosine analogue, (S)-HPMP-5-azaC: chemistry and antiviral activity

..Compared to the parent molecule, the amidate prodrug was 10-fold less active against FIV in cell culture, whereas the alkoxyalkyl ester prodrug was 200-fold more potent in inhibiting FIV replication in vitro...

..Considering the potential pharmaceutical applications, 5-azacytosine and 5,6-dihydro-5-azacytosine appear to be so far the most effective cytosine mimics for the design of novel antiviral and anti-tumor drug candidates...