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CHICAGO — Taking B vitamins can prevent a common type of vision loss in older women, according to the first rigorous study of its kind. It's a slight redemption for vitamin supplements, which have suffered
recent blows
from research finding them powerless at preventing disease.

Rates of women who are opting for preventive mastectomies, such as Angeline Jolie, have increased by an estimated 50 percent in recent years, experts say. But many doctors are puzzled because the operation doesn't carry a 100 percent guarantee, it's major surgery -- and women have other options, from a once-a-day pill to careful monitoring.

Age-related macular degeneration is the leading cause of blindness in people 65 and older, with nearly 2 million Americans in the advanced stage of the condition. It causes a layer of the eye to deteriorate, blurring the center of the field of vision and making it difficult to recognize faces, read and drive. There's no cure, but treatment, including laser therapy in some cases, can slow it down.

Preventing it has been more elusive.

"Other than avoiding cigarette smoking, this is the first suggestion from a randomized trial of a possible way to reduce early stage AMD," said William Christen of Harvard-affiliated Brigham and Women's Hospital in Boston, who led the research. He said the findings should apply to men as well.

The women in the study who took a combination of B vitamins — B-6, folic acid and B-12 — reduced their risk of macular degeneration by more than one-third after seven years compared to women taking dummy pills.

The study, involving more than 5,000 women ages 40 and older at risk for cardiovascular disease, appears in Monday's Archives of Internal Medicine.

Allen Taylor, director of the Laboratory for Nutrition and Vision Research at Tufts University in Boston, said the study was strong because patients were assigned at random and followed for a long time. But because the findings were teased out of a larger experiment for heart disease, there wasn't strict categorization of the type and severity of the eye disease, said Taylor, who does similar research but was not involved in the new study.

Among women taking the B vitamins there were 55 cases of AMD. In the placebo group, there were 82 cases. More serious cases, causing significant vision loss, totaled 26 in women taking B vitamins and 44 in those taking dummy pills.

There were too few cases of the most advanced AMD to make claims about vitamins' potential benefits, Christen said.

B vitamins lower homocysteine, a blood substance once thought to raise heart disease risk, but the nutrients weren't helpful for that in the larger study on cardiovascular disease.

The eye's small blood vessels may respond better to B vitamins' effect on homocysteine than the body's large vessels, Christen said.

It's too soon to recommend B vitamins to people who want to prevent age-related vision loss, he said. But people who already have the disease should talk to their doctors about over-the-counter eye-protecting supplements, including vitamins C and E and zinc, which prior studies have shown slow the disease.

The study was funded by the National Institutes of Health. Vitamins and placebos were provided by chemical maker BASF Corp., which did not participate in the study otherwise. Some of the researchers reported past funding from pharmaceutical and nutritional supplement makers.