Once this system is charged or kindled, it can sustain a high level of arousal with little or no external stimulus and eventually this could lead to hypocortisolism [adrenal insufficiency].

Seizure activity may spread to adjacent structures of the limbic-hypothalamic-pituitary axis in the brain, which might be responsible for the varied symptoms that occur among patients with ME/CFS.

In addition, kindling may also be responsible for high levels of oxidative stress [free radicals], which has been found in patients with ME/CFS.
Source:Neuroscience & Medicine, Apr 2011;2, 14-27. DOI:10.4236/nm.2011.21003, by Jason LA, Sorenson M, Porter N, Belkairous N. DePaul University, Center for Community Research, Chicago, Illinois, USA. [Email: ljason@depaul.edu]

This article perfectly agrees with the theory of ME proposed by Dr Ashok in the U.K. who offers amygdala retraining to help the mind and nervous system calm down and not be so over-reactive to past or present stressors. His training CD's seemed very helpful to me(I've had ME for over a decade and have tried many many things.)