Uncomplicated Nausea and Vomiting in the Emergency Department

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Nausea and vomiting is a common complaint in the emergency department. Treatment is important for many reasons. In addition to patient comfort, there are adverse effects secondary to vomiting such as dehydration, metabolic alkalosis, Mallory-Weiss tears, and aspiration. Two mediations common used for nausea in ED patients include Ondanesetron and Metoclopramide.

Condition or disease

Intervention/treatment

Phase

NauseaVomiting

Drug: OndansetronDrug: Metoclopramide

Phase 4

Detailed Description:

This study will compare Ondansetron 4 mg vs 2 mg vs Metoclopramide 10 mg to look for efficacy in nausea and vomiting treatment for patients in the ED with many different causes. We will also look for cost effectiveness as well, since Metoclopramide is much less expensive than Ondansetron, which is less expensive at lower doses. There is little research about nausea medication in the ED literature even though these medications are used frequently in the ED for many causes of nausea.

To delineate whether a high vs low dose of Ondansetron in better as opposed to an alternate medication -- Metoclopramide in the ED setting for uncomplicated nausea and vomiting. [ Time Frame: 30 minutes ]

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Ages Eligible for Study:

18 Years and older (Adult, Senior)

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

No

Criteria

Inclusion Criteria:

18 years or older with nausea and at least 1 episode vomiting in the last 12 hours presenting to the York Hospital Emergency Department

Exclusion Criteria:

Patients known to have hypersensitivity to the drugs ondansetron or metoclopramide

gastrointestinal hemorrhage, mechanical obstruction or perforation

patients with pheochromocytoma

seizure disorder

patients receiving other drugs which are likely to cause extrapyramidal reactions such as butapherones and phenothiazines