Antidepressants are traditionally used in the treatment of depression. While these drugs rapidly inhibit the reuptake of neurotransmitters in the synaptic terminal by blocking the serotonin and norepinephrine transporters, ...

Yersinia pestis, the causative agent of plague, can be transmitted by infected-flea bite or inhaled aerosol. Both routes of infection have a high mortality rate, and pneumonic infections of Yersinia pestis represent a ...

In the NZM2410 model of murine lupus, Sle1b mediates anti-nuclear autoantibody (ANA) production. Our goal is to determine the causative gene in the Sle1b locus. Seven members of the SLAM/CD2 family are located within the ...

The splicing mechanism of group II introns is analogous to that of nuclear introns and it is generally thought that both share a common ancestor. This work contains two studies of group II intron splicing in yeast mitochondria. ...

Background: The purpose of this study was to determine the incidence and clinical significance of abnormal complete blood counts (CBCs) obtained during follow-up of childhood cancer survivors.
Methods: A retrospective ...

Eating disorders are a very complex and serious psychiatric condition that require an ongoing commitment to a comprehensive treatment plan involving both medical and psychological intervention. Increases in the prevalence ...

Hydroxysteroid dehydrogenases (HSDs) catalyze the interconversion of inactive steroids and active hormones. HSDs use nicotinamide cofactors in the cytosol and endoplasmic reticulum (ER) lumen to either reduce or oxidize ...

Clinicians and researchers have expressed concern about the potential confound of psychomotor skills on Continuous Performance Test variables commonly used in AD/HD assessments. Several studies have addressed this ...

BACKGROUND: Vietnamese-Americans underutilize mental health services. Several factors have been proposed to influence rates of service utilization within this population, including cultural identification and families' ...

CREB3L1/OASIS is a cellular transcription factor synthesized as a membrane- bound precursor and activated by regulated intramembrane proteolysis in response to stimuli like ER stress. By comparing gene expression between ...

3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase (HMGR) catalyzes the conversion of HMG CoA to mevalonate, which is the rate limiting step in the production of cholesterol and numerous nonsterol isoprenoid products. ...

The discovery of two missense mutations (A53T and A30P) in alpha -synuclein that are genetically linked to Parkinson's disease, together with alpha -synuclein being the major component in Lewy bodies, has generated extensive ...

Neurotransmitter release is an exquisitely regulated process that transmits signals between neurons. The release process includes: docking of synaptic vesicles at the active zone of the pre-synaptic plasma membrane, priming ...

The serpins belong to a superfamily of protease inhibitors that employ a unique suicide substrate-like inhibitory mechanism. In this mechanism, target protease becomes acylated at the catalytic serine. Deacylation fails ...

West Nile virus (WNV) has rapidly become a pathogen of global importance over the past two decades. Its recent association with severe neurological disease and emergence in the Western Hemisphere suggest that the virus has ...

The purpose of this thesis dissertation is to document the process that led to the development of an Instructional Guide and a Model Website for a medical research lab to utilize as a resource for creating a website for ...

The goal of this thesis project was to create an instructional video for first-year obstetrics and gynecology residents to instruct them on the anatomy and procedural steps involved in the layered repair of a fourth-degree ...