5 Things No One Tells You About Taking Antidepressants

Let me say right off the bat that no medication has ever helped me as much as my sad face-repellent pills, and that includes the anti-worm meds they gave me in the '90s after I ate a live pig at an Anthrax concert. This article is in no way intended as a warning that you should give up your medication. But there are some things you should know about antidepressants so you don't end up in a fetal position, clutching your tinfoil hat and writing love letters to pickles. For instance, before I was balls-deep in my own meds, I didn't know that ...

#5. They Can Make You More Depressed

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As a general rule of thumb, the average person who needs the help of antidepressants can expect to be on them for about a year. Those are typically cases of people who have short term depression and need a little help with correcting some chemical imbalances or suppressing their urges to silence their peers with flame. If that level of depression took the form of entertainment, it would be an Adele song, or maybe the weeks following Luke Skywalker's discovery that his dad was a murder robot.

Long term depression and its treatment is more like a full season of Game of Thrones, your mind frantically trying to organize and prioritize rapid images of throat slitting, disembowelments, fucking, and bare penises into some semblance of order. It is chaos, and it needs a much longer management plan. Here's the problem, though:

Comstock/Stockbyte/Getty ImagesClearly, not enough fucking.

Recent studies have found that prolonged use of antidepressants actually promotes depression. There is some science behind it that I don't understand because I'm an idiot, but don't feel bad if you don't either, because the researchers themselves aren't quite sure what causes it. So, at least in this instance, we can all say that we're basically as smart as scientists. And I'm going to.

Anyway, it's something you have to take into consideration when talking to your doctor. If you've had problems with depression most of your life, I think it's pretty safe to assume that you'll be a likely candidate for long term treatment, so you're not exactly going into the conversation blind. It's easy for us to think that because this person is a doctor, she knows everything there is to know about the medication, but that just isn't true. There is a ridiculous amount of meds out there, all with a billion side effects -- it's impossible to have them all memorized. Even with the help of a computer, there will be some things that will be overlooked. Some of these studies are so recent that the doctor may not have heard of them yet.

Digital Vision./Photodisc/Getty Images"Penicillin? Are you sure you're not just making that word up?"

But the point is that it's perfectly OK to say, "I was reading recent medical articles on the subject, and there are some legitimate dangers in long term medication. And now that I've done part of your job for you, I demand that you pay me for this visit. That'll be one billion dollars."

#4. They Can Make You Suicidal

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In 2004, and again in 2007, the FDA required a "black box" label to be put on all antidepressants that warned of increased suicidal thoughts, particularly in children (later extended to the 18-to-24 age group), and especially in the first two months of use. You may recognize that label as the same one they use at the beginning of Dancing With the Stars. It has saved many a life.

If you're like me, your first thought jumped to "Well of course they're at an increased risk of suicide. They're on antidepressants, which means they're depressed right out of the gate in this study!" But those of you who are smart will read the study and see that the participants were groups of depression-afflicted teens who were given medication and placebos. The ones who were given the latter showed fewer occurrences of suicidal thoughts than those who were on the actual medication.

Stockbyte/Stockbyte/Getty ImagesHere we see a teen taking her "Prozac."

For that reason, anyone under that age cap needs to be closely monitored when taking pretty much any of this type of medication. And just to be safe, most doctors monitor all patients, regardless of age. Except the ones they don't like, obviously. They give those people extra prescriptions and tell them that swimming with sharks is a great form of stress relief.

If you're on any type of antidepressant and you find yourself having suicidal thoughts or feel that your depression is worsening, you need to talk to your doctor right away. Don't put that shit off, because there's a very good chance that you're feeling the effects of a bad match between your brain and that chemical, like your mind knows that you need more Star Wars but completely shuts down during the prequels. And for the love of Zod, don't stop taking them abruptly -- that can be just as bad, if not worse.

#3. Combining Them With Common Medications Can Kill You

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I am on two medications: venlafaxine (an antidepressant) and tramadol (pain management for a bad back). When the doctor originally prescribed these, she told me that the two could be taken at the same time without any problems, which leads me to believe that I'm one of the patients she hates, because I later found out that it can cause serotonin toxicity, which can fucking kill you.

Understand that I've been taking the two without dying very often, so I'm not saying that the combination is guaranteed to be lethal. But the chances aren't zero, either -- in 2005, 118 people died from it. Like most drug interactions, it has levels of severity, including -- wait for it -- worsening of depression! Yay! Yet another thing that hands your original condition a pool cue and tells it that you called its mother a whore.

Digital Vision/Valueline/Getty ImagesYou gonna just take that shit, Big D?"

This is the part that I ran into not very long ago. I had what appeared to be serotonin toxicity to a minor degree, as well as the ill effects of prolonged antidepressant use, and I just mentally crashed. I hadn't felt that bad since I was a teenager, high, alone, and listening to the Cure, thick layers of jet black eyeliner running down my pasty white face. At least I think that's when I was a teenager. That very well could have been last Thursday. Time gets fuzzy when depression takes you into the valleys. It's pretty easy to go in fully clothed but walk out the other side wearing nothing but a sequined cape, David Hasselhoff's face tattooed across your ass.

The point is that it's a good idea to not only ask your doctor and pharmacist about the drug interactions, but double check it when you get home just to be sure. Even taking something ordinary like ibuprofen in combination with my antidepressant can cause easy bruising and excessive bleeding. That's why I had to give up my heavyweight championship belt after my last UFC victory.

Creatas/Creatas/Getty ImagesNow I just invite my kids' friends over and challenge them to matches.