Thank you for contacting PreSonus Technical Support. We're sorry to hear about the issue you have encountered with Melodyne in Studio One 4.

We apologise for this issue. This is a known issue that has already been reported to the development team. We will alert you through a support ticket follow-up to notify you if and when an update is available and where to get it.

We recommend reading the latest release notes when our software is updated to see if your issue is resolved. You can find the latest release notes in your my.presonus.com account.

In the meantime, as a workaround, you can simply leave melodyne docked in the main Studio One window.You could also load a VST/AU instance of Melodyne to your track(s), and transfer audio parts into the plugin to edit audio there.