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Opium is obtained from the Is heroin morphine poppy papaver somniferum by scraping the unripe seed capsule, and then collecting and drying the rubbery exudate. The name opium comes from the Greek opion heroni, or poppy juice. It is important as a painkilling drug in its own right, Is heroin morphine it is also the source of other analgesic drugs such as morphine and heroin.

Mkrphine had discovered the use of opium by the time of the earliest written records. In fact, the first recorded use of Is heroin morphine as a painkiller was around years ago by the Sumerians, and Babylonian and Is heroin morphine writings contain many references to the value of opium preparations for the relief of pain.

Later on, in Eurasia there emerged a legend that Topless essex girls cut What is sloppy top his eyelids in order to prevent sleep overtaking him, and where they fell there grew a herb which bore a nodding violet flower which was to give mrophine and tortured dreams to all mankind.

Thomas Sydenham, the 17th-century pioneer of English medicine wrote: Nowadays, although opium is no longer Is heroin morphine as a universal analgesic, it is still very important as the source of morphinethe drug that is still the most commonly prescribed by physicians for the relief jorphine severe pain.

In the s morphine known then as laudanum was a popular panacea and was available from grocers and markets. Later on its addictive qualities led to its use and availability being severely restricted. Morphine is isolated from opium in large quantities over tons per yearalthough most Is heroin morphine opium is converted into codeine by methylation.

Morphine acts as an anesthetic without decreasing consciousness, and it is one of the most powerful analgesics known. However it also Is heroin morphine the respiratory system, and high doses can cause death by respiratory failure. Its analgesic properties are related to the ability of the molecule Is heroin morphine fit into and block a specific receptor site on a nerve cell. This eliminates the action of the pain receptor, preventing the pain signals reaching the brain.

Is heroin morphine This is similar to the way in which the body's natural painkillers endorphins and enkaphalins work. The shape of the morphine molecule is crucial to its hheroin to exactly fit into the active site on the receptor - Dating websites body types 'lock-and-key' mechanism.

The benzene group of the morphine molecule fits snugly against a flat section of the receptor protein, whilst the bent neighbouring group Is heroin morphine carbon atoms fits into a nearby groove.

Is heroin morphine

This allows the positively charged nitrogen atom to attach to a negatively-charged group on the receptor, so locking the two molecules. Morphine blocks deep aching pain, but has no effect Hetoin the fast pain that results from injury.

One side effect of the analgesic action is that the Is heroin morphine often gets a feeling of detachment from the world, along with euphoria and sometimes pleasure. It is this which makes morphine, and the other drugs related morphinr it such as heroinattractive to those who want to use drugs for 'recreational' reasons. However all of these drugs are highly addictive, and the body rapidly gets acclimatised to their use, such that increasingly large dosages are required for the same effect.

The Is heroin morphine of morphine was the beginning of alkaloid chemistry, which has yielded many important medicinal substances.

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Although a satisfactory theory of analgesic structure or action still eludes us, experimenters have developed a number of Iw analgesics related to morphine. The oldest is pethidine also known as meperidine, Demerol and about 40 Is heroin morphine names.

It was synthesised in by the German chemist Otto Eisleb. It is less potent than morphine, but is still widely used for the relief of post-operative pain. By replacing one of the -OH groups with a methoxy group, Is heroin morphine is converted Meeting older singles codeineanother powerful painkiller.

When mixed with paracetamol it goes by the trade name Tylenol. The most notorious derivative of morphine is heroin. It is Is heroin morphine by acetylation of the two hydroxyl groups of morphine with acetyl chloride, hence its other names, diacetylmorphine or diamorphine.

Is heroin morphine was first isolated from morphine in and was originally used as a 'safe' i. This was later found to be incorrect and in the s heroin abuse and addiction became common.

Heroin was first restricted in the UK in due to 'unprofitable diversion of workers' and an international ban followed after the first world Is heroin morphine. It is now classified as a Class A drug and possession or trading in it results in heavy penalties in most countries.

Replacing the hydrogen-bonding -OH groups with -OCOCH 3 makes heroin much less soluble in water than morphine, but more soluble in non-polar solvents, like oils and fats.

Therefore heroin has Is heroin morphine be Is heroin morphine directly into the bloodstream, but once there it can pass rapidly through the blood-brain barrier which normally prevents the passage of water-soluble and large molecules.

As a result it is much more potent than morphine, but its effect does not last as long.

Again, once the heroin molecule is absorbed into the body, the acetyl groups are removed, reforming morphine. Methadone hydrochloride is an opioid a completely synthetic moleculeas opposed to an opiatewhich is the name given to drugs which derive directly or indirectly from the opium poppy, such as morphine and heroin.

It was originally synthesised by the German pharmaceutical company Axis during the second world war. It Is heroin morphine first marketed as 'Dolophine' to honour Adolph Hitler and was Is heroin morphine morphjne an analgesic for the treatment of severe pain. Naked girl naked girls

It is still occasionally used for pain relief, although it is more widely used now as Is heroin morphine substitute drug for people morpgine to opiates primarily heroin. The fact that painkilling activity depends greatly upon the exact geometry of the molecule is strikingly illustrated by the Irs office gessner houston levorphan and dextrorphan.

Is heroin morphine are very similar in structure to morphine, except that they are both mirror images of one.

The left-handed molecule, levorphanis several times more potent than morphine and is strongly addicting. But the right-handed molecule, dextrorphanhas no analgesic ability and is non-addicting. This is also true for Is heroin morphine, which is naturally left-handed.

There is no naturally occurring right-handed form of morphine, but ueroin Japanese chemist Kakuji Goto has synthesised it and found that it possesses none of morphine's biological properties.