Handler's manager, Irving Azoff, confirmed the decision, telling THR that Handler will end her show, "Chelsea Lately," when her contract expires at the end of this year. Azoff said Handler is open to a number of alternatives, including radio, or hosting another late-night talk show on another network or digital platform.

"We have at least seven suitors and many ideas," Azoff told THR.

THR reports that Handler's reps have already arranged meetings for the comedienne at Sony Television, Lionsgate, and FX, though her hefty price tag -- a reported $9 million annually from E! -- may preclude her from getting offers for a nightly hosting gig similar to "Lately." However, Handler is currently enjoying her latest number one New York Times bestseller ("Uganda Be Kidding Me"), and is slated to shoot her first stand-up special this summer, which will air on cable later this year.

Handler made headlines when she openly criticized E! earlier this year, telling Howard Stern that the network was "a sad, sad place to live" and that "They don't know what they're doing. They have no ideas. It's a failure."

Through a spokesperson, E! declined to "comment on the future of 'Chelsea Lately' at this time."