Applications/Dilutions

Reactivity Notes

Packaging, Storage & Formulations

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Buffer

PBS (pH 7.3), 1.0% BSA and 50% Glycerol

Preservative

0.02% Sodium Azide

Purity

Immunogen affinity purified

Alternate Names for LNK/SH2B3 Antibody (2B11)

IDDM20

LNK

LNKSH2B adapter protein 3

Lymphocyte adapter protein

Lymphocyte-specific adapter protein Lnk

SH2B adaptor protein 3

SH2B3

Signal transduction protein Lnk

Background

This gene encodes a member of the SH2B adaptor family of proteins, which are involved in a range of signaling activities by growth factor and cytokine receptors. The encoded protein is a key negative regulator of cytokine signaling and plays a critical role in hematopoiesis. Mutations in this gene have been associated with susceptibility to celiac disease type 13 and susceptibility to insulin-dependent diabetes mellitus.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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