Most people use to much and that can cause trouble no matter which one you use.

When using any thread sealer apply "Only" one drop to the screw and none to the
threaded hole and it will release without heat.

The 222 does not get as hard as the the red and when you break the screw loose it
does not snap like the others(Making you think that you broke the screw).

The trick like Trickymissfit said is to use it sparingly.

J E CUSTOM

I hate to think about how many bottles of Loctite I've bought thru the years, and I've used it on everything from a #2-56 all the way out to a 3" extra fine thread. The only thing I never used it on was Timken bearing nuts. I've even had some stuff where red wouldn't hold, and had to come up with something better. For extremely fine threads, I found that Vibratite was better ( something like a 1.5"-32). Just apply one small drop and let it dry before assembeling. Loctite on the otherhand is anarobic, and will not harden till air is removed. The best stuff I ever found was some thread locker that came in a black bottle with a green lable. Think the company went belly up as I never could get anymore. I recommend that everybody use the Loctite Primer on both the female and male thread form before using the regular Loctite. Just let it dry for about five or six minutes before applying the Loctite. You'll get a better job. One otherthing about Loctite is that you ought to keep it in the fridge when your not using it. Lasts longer that way.
gary