Exemple 1: RP124 - adRP

On the left, you can configure TASE's tests.
First, select TAAC test (designed for dominant transmission)

Select couples and children to analyse.
Couple "0_0" aren't selected because they represent parents absent of the tree.
Couple "2_1" and "33_0" aren't selected because we haven't daata for one of the parents.

On status table, Individuals incluted in the analysis are automaticaly selected.
You can check each status.

Turn Stats "On" if you want some percentages of the test.
Click on "Start Test" button.

After some minutes...

Test is done.
Click on "Visualisation" button

You can see all chromosomes,[legende]
and tree candidate regions (in blue).

When you overflow each region, You can see start-end position, length of the region and number of SNPs.
In this case, region on chrom.1 contains 1124 SNPs,
regions on chrom.9 and chrom.16 contains less than 15 SNPs (they match on centromere)

When you overflow triangles right of chromosome,
you can see name of previously reported gene in retinopathy and this position.
In this case PRPF3 and SEMA4A genes are in candidate region of chrom.1
If you click on gene, the NCBI description of gene is displayed.

Click on Chromosome name to display Sequece view

This view zoom on one chromosome and present the result for each SNP. [legende]

All chromosome is red except the candidate region.
Click on one letter display his chromosomal position.
Overflow a letter show position and rsID.

If you show QS summary, you found two known genes already referenced in diseases

To conclude, this two candidate genes were sequenced and one causative mutation was found on PRPF3.

Exemple 2: RP692 - arRP with consanguinity

This family have autosomic recessive form of retinal dystrophie, and inbreeding.

On TASE's Homepage, click on [Tests]

Select family RP692

On the right, the family tree is displayed

On the left, you can configure TASE's tests.
First, select CGAA and CHoR tests (designed for recevive transmission and consanguinity)

Select individuals incluted in the analysis, first considere only parents and relatives of index
You can check each status.

Turn Stats "On" if you want some percentages of the test.
Click on "Start Test" button.

After some minutes...

Test is done.
Click on CHoR "Visualisation" button

You can see all chromosomes,[legende]
And nine candidate regions (in blue).

Some of this regions corresponding to centromere.
On QS summary you can see that region on Chrom. 2, 10 and 14 matche with known genes,[legende]

On Genome view, When you overflow triangles right of chromosome,
You can see name of previously reported gene in retinopathy and this position.
If you click on "RP", you can see previously reported genes in this pathology.
When you overflow triangles right of chromosome, You can see gene name.
In this case FAM161A,SNRNP200,MERTK and TTC8 genes are in candidate region.
If you click on gene, the NCBI description of gene is displayed.