Guzzo appeared regularly on KIRO-TV and KIRO (AM) radio, where he was also an editorial consultant. In 1986, a commentary attacking rock music fans caught the attention of the Seattle crossover thrash band The Dehumanizers. In response the group recorded a satirical song "Kill Lou Guzzo" on their debut 7" EP.[3] The record used unauthorized audio clips from Guzzo's TV editorial. Group members later received a cease and desist letter from KIRO and Guzzo.[4]

He had several e-books published, and has had numerous speeches, talks, and commentaries posted to YouTube. After his retirement from KIRO, Guzzo maintained a website where he continued to write a daily commentary on current events. He was a resident of Newcastle, Washington. Guzzo died in 2013 at the age of 94.[5]