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The Arab house of Islam

The Prophet Muhammad
has an extensive genealogy.
How reliable it all is I do not know.
But there has long been interest in connecting western Christian lines to it.

There is not yet any proven descent from the Prophet Muhammad
to medieval European Christian lines.
If any descent is established, it will probably be through
medieval Spain and Portugal.

Attempted descent (not generally accepted):

The following attempted genealogy is seen in a number of places,
and would imply a descent of most of the West from the Prophet Muhammad.
However it
is not generally accepted by genealogists.
Alfonso VI did have a Muslim mistress/wife
Zaida, but it is not proven she was the mother of Rodrigo Gonzalez de Lara's wife.
Also Zaida was said by some to daughter of the Emir,
but more usually said to be his daughter-in-law, thus wiping out the whole line above her.
For discussion see:

However it is still almost certain that,
if we accept that
the Prophet existed, had wives and children,
and there was great status in marrying his descendants,
then very soon (within say two to three hundred years)
all of the prominent families of Islam
would be descended from him,
even if the specific descents above are not reliable.

Many prominent people in the Islamic world
claim descent from the Prophet.
See the titles
Sayyid
and
Sharif.

The claimed descent of the Iraqi dictator
Saddam Hussein
from the Prophet
is fiction.
He was a peasant
who did not even know his own birthday.
See article:
"The committee of Ashrafs, a group in Baghdad that guards the Muslim Prophet's genealogy,
has admitted that Saddam forced them to add him to Muhammad's family tree.
Three days after he was captured by American forces, the committee corrected the record."

Most people are probably descended from the Prophet Muhammad anyway

If we accept the argument above that, even if the exact lines aren't known,
most of the prominent families of Islam
would have soon ended up descended from the Prophet,
then most of modern Islam would descend from the Prophet.

Simply put, if anyone at Muhammad's time left
a reasonable number of descendants,
they are probably the ancestor of most of the West today,
even if no specific descent can be proved.
See full discussion on
Common ancestors of all humans.