JetBlue captain Clayton Osbon is taken off plane after it made an emergency landing in Amarillo.

LAS VEGAS - A JetBlue captain who yelled about a bomb and urged passengers to pray on a Las Vegas-bound flight has been suspended, the airline said Wednesday.

Clayton Osbon has been taken off active duty pending a review of the incident, JetBlue Airways spokeswoman Allison Steinberg said. Passengers wrestled Osbon to the ground after his bizarre rant, as a co-pilot shut him out of the cockpit and took command of the Tuesday morning flight from New York.

Passengers first noticed something was wrong when Osbon stormed out of the cockpit and tried to force his way into an occupied bathroom. The captain's co-workers tried to calm him as he became more jittery, coaxing him to the back of the plane while making sure that he didn't return to the plane's controls.

Then he sprinted up the cabin's aisle, ranting about a bomb, screaming that the plane would "They're going to take us down!" and urging confused passengers to pray.

"Nobody knew what to do because he is the captain of the plane," said Don Davis, the owner of a Ronkonkoma, N.Y.-based wireless broadband manufacturer who was traveling to Sin City for a security industry conference.

"You're not just going to jump up and attack the captain," Davis said.

But four men did tackle just that, using seat belt extenders and zip tie handcuffs to restrain and pin Osbon to the floor for more than 20 minutes while the co-pilot and an off-duty pilot who was aboard landed the plane in Amarillo, Texas.

The company's CEO and president Dave Barger told NBC's "Today" show that Osbon is a "consummate professional" whom he has "personally known" for years. Osbon has been a pilot for JetBlue since 2000.

There is nothing in the captain's record to indicate he would be a risk on a flight, Barger said Wednesday.

It was not clear if Osbon would face any criminal or civil charges for disrupting the flight.

"Clearly, he had an emotional or mental type of breakdown," said Tony Antolino, a security executive who sat in the 10th row of the plane and tackled the pilot when he tried to re-enter the cockpit.

"He became almost delusional," Antolino said after arriving in Las Vegas from Rick Husband Amarillo International Airport some six hours after schedule.

Josh Redick, who was sitting near the middle of the plane, said the captain seemed "irate" and was "spouting off about Afghanistan and souls and al-Qaida."

Elton Stafford, who lives across the street from Osbon in Richmond Hill, Ga., said he was shocked at the captain's outburst.

"Clayton's a great guy. Loves to have a good time, loves the outdoors. He just loves people," Stafford said late Tuesday. "They're the kind of neighbors that everybody wants."

The airline described the incident as a "medical situation" involving the captain of JetBlue Airways Flight 191 from New York's John F. Kennedy International Airport. Airline officials said he was taken to a hospital.

The outburst came weeks after an American Airlines flight attendant was taken off a plane for rambling about 9/11 and her fears the plane would crash. John Cox, an aviation safety consultant and former airline pilot, said he could recall only two or three cases in 40 years where a commercial pilot had become mentally incapacitated during a flight.

Gabriel Schonzeit, who was sitting in the third row, said the captain said there could be a bomb onboard.

"He started screaming about al-Qaida and possibly a bomb on the plane and Iraq and Iran and about how we were all going down," Schonzeit told the Amarillo Globe-News.

"A group of us just jumped up instinctually and grabbed him and put him to the ground," Antolino said.

The Federal Aviation Administration said the co-pilot had locked the cockpit.

An off-duty JetBlue captain who was a passenger on the flight entered the flight deck and took over Osbon's duties before landing in Amarillo, the airline said in a statement.

The customers and crew "just did a great job," JetBlue's Barger said. "That was a true team effort at 35,000 feet."

Osbon was taken to a hospital, the airline said.

The FBI was coordinating an investigation with the airport police, Amarillo police, the FAA and the Transportation Safety Administration, said agency spokeswoman Lydia Maese in Dallas. She declined to comment on arrests.

Airlines and the FAA strongly encourage pilots to assert themselves if they think safety is being jeopardized, even if it means contradicting a captain's orders, Cox said. Aviation safety experts have studied several cases where first officers deferred to more experienced captains with tragic results.

Unruly pilots, crew and passengers have disrupted flights in the past.

Just hours after Osbon's breakdown, crew aboard a US Airways flight from Charlotte, N.C., to Fort Myers, Fla., had to restrain a disruptive female passenger. Lee County Port Authority police spokeswoman Victoria Moreland said a passenger from the flight was arrested Tuesday afternoon but declined to elaborate.

Earlier this month, an American Airlines flight attendant took over the public-address system on a flight bound for Chicago and spoke for 15 minutes about Sept. 11 and the safety of their plane, saying, "I'm not responsible for this plane crashing," according to several passengers.

Passengers wrestled the flight attendant into a seat while the plane was grounded at Dallas-Fort Worth International Airport; the flight attendant was hospitalized.

In 2008, an Air Canada co-pilot was forcibly removed from a Toronto-to-London flight, restrained and sedated after having a mental breakdown on a flight.

The FAA is likely to review Osbon's medical certificate - essentially a seal of approval that the pilot is healthy. All pilots working for scheduled airlines must have a first-class medical certificate. The certificates must be renewed every six months to a year, depending on the pilot's age. To receive the certificate, the pilot must receive a physical examination by an FAA-designated medical examiner that includes questions about pilot's psychological condition. Pilots are required to disclose all physical and psychological conditions and medications.

Charlie Restivo, who was heading to the Las Vegas security conference and sat in the plane's fourth row, said he thought it was clear that the pilot had suffered a medical episode.

"I don't think when he got up this morning that that's what he was intending to do," he said. "Unfortunately, I just think it happened to him."

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Bomkamp reported from New York. Joan Lowy in Washington, D.C., and Betsy Blaney in Lubbock, Texas, contributed to this report.