Comments 5

I havent gone to anywhere near that scale, but ...
Wordpress.com and edublogs both run on multisite,
I think that futre scale is not a problem.
If you expect to grow to that size i suggest you use the multidb plugin to split it up a bit

Per holding files though and dealing with disk space, your going to need RAID to handle it across multiple servers, it is going to require some networking setup. One other method is to use Federated Databases so basically you can spread out the databases autonomously and they are able to be spread across multiple servers to reduce load (decentralized) http://en.wikipedia.org/wiki/Federated_database_system It is a bit like RAID but for Databases, there is always the option for RaiDB there is also the option for RAIDb (Redundant Array of Inexpensive Databases) these are just some of the different networking options though, multi-db is a great way of spreading things as well. Try different caching systems as well, and set embedded CSS images to become URI string to help kill of some load, it would also be smart to minify CSS and JS as well as do mod_deflate for browsers that allow it. This helps a lot with load time, and helps to increase server performance and decrease the load created by the amount of people connecting at once, it also conserves bandwidth.

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