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LOVENOX® helps reduce the risk of deep vein thrombosis—also known as DVT blood clots—to help avoid a potential pulmonary embolism in patients undergoing abdominal surgery, hip-replacement surgery, knee-replacement surgery, or medical patients with severely restricted mobility during acute illness. Learn how to self-inject LOVENOX® at home, and read about possible side effects.

How to Self-Inject LOVENOX®

Most patients or caregivers can administer LOVENOX® injections after learning how to properly inject it. Review and follow all the steps outlined below to ensure proper administration and safe disposal of LOVENOX® prefilled syringes. Be sure to discuss these steps with your doctor before you administer LOVENOX® for the first time.

If you have any questions about LOVENOX®, please speak to your doctor or call the Patient Hotline at 1-800-633-1610.

Step 2. Sit or lie in a comfortable position,
so that you can see your abdomen.

Step 3. Choose an area on the right or left
side of your abdomen, at least 2 inches from your belly button. Think "love handles."

Step 4. Clean the injection site with an
alcohol swab. Let dry.

Step 5. Remove the needle cap by pulling
it straight off the syringe and discard it in a sharps collector. If you did not
receive a LOVENOX®Discharge Kit from the hospital, you can obtain a sharps collector
from your pharmacy.

Step 6. Hold the syringe like a pencil in
your writing hand.

Step 7. With your other hand, pinch an inch
of the cleansed area to make a fold in the skin. Insert the full length of the needle
straight down–at a 90° angle–into the fold of skin.

Step 8. Press the plunger with your thumb
until the syringe is empty.

Step 9. Pull the needle straight out at the
same angle that it was inserted, and release the skin fold.

Step 10. Point the needle down and away from
yourself and others, and push down on the plunger to activate the safety shield.

Step 11. Place the used syringe in the sharps
collector.

Important Safety Information for
LOVENOX®

If you are receiving epidural or spinal anesthesia or undergoing spinal puncture,
and taking LOVENOX® (enoxaparin sodium injection), you may be at increased risk
of developing a blood clot in or around the spine, which can result in long-term
paralysis. Your risk may be further increased if you:

Take nonsteroidal anti-inflammatory drugs (NSAIDs), platelet inhibitors, or
other anticoagulants, such as aspirin or blood thinners

Have an indwelling epidural catheter

Have a history of spinal trauma, or repeated spinal
anesthesia or punctures

Have a history of spinal deformities or spinal surgery

It is important to contact your doctor immediately if you experience symptoms such
as tingling, numbness (especially in the lower limbs), and muscular weakness.

LOVENOX® should not be used in patients who are actively bleeding or who have
a low count of blood cells called platelets, which aid in clotting. This is a condition
called "thrombocytopenia." LOVENOX® also should not be used in patients who
are allergic or sensitive to LOVENOX® or enoxaparin, heparin, or pork products.

LOVENOX® must be used with care in patients who have any of the following: problems
with clotting, uncontrolled high blood pressure, a recent ulcer, impaired vision
due to diabetes, kidney problems, and excessive bleeding. Pregnant women with mechanical
prosthetic (artificial) heart valves may be at higher risk for blood clots. These
patients who are treated with LOVENOX® must be carefully monitored by their
doctor.

Some patients on LOVENOX® can experience drops in their platelet counts, a condition
called "thrombocytopenia." Also, a serious but rare condition called "heparin-induced
thrombocytopenia" can occur with LOVENOX®. If you have had this condition, you
must notify your healthcare professional.

LOVENOX® alters the blood’s ability to clot. Excessive bleeding (hemorrhage),
leading to death, has occurred with LOVENOX®. Bleeding can occur at any site
with LOVENOX® use. The use of aspirin and other NSAIDs may enhance the risk
of excessive bleeding. Be sure to tell all your doctors and dentist about all of
the medications you are taking, including those you are taking without a prescription,
such as aspirin or other NSAIDs. Also be sure to tell your doctor or dentist you
are taking LOVENOX® before any surgery is scheduled and before any new drug
is taken.

All patients should be carefully monitored by their doctor while taking LOVENOX®.
Your doctor is likely to obtain blood tests that measure your blood count and check
for signs of hidden bleeding while you are on LOVENOX®.

You should call your doctor immediately if you notice any of the following: unusual
bleeding or bleeding that lasts a long time, unusual bruising, signs of thrombocytopenia
(such as a rash or dark spots under the skin), tingling or numbness (especially
in the lower limbs), and muscular weakness.

The most common side effects from the use of LOVENOX® are mild pain, irritation,
bruising, or redness of the skin at the site of injection. Other common side effects
include bleeding, anemia, diarrhea, and nausea.

Do not stop taking LOVENOX® without first talking to the doctor who prescribed
it for you.

For specific questions about your health, you should always consult your doctor
or a qualified healthcare professional who is responsible for your care.

For more information, call sanofi-aventis U.S. Medical Information Services at 1-800-633-1610.

Indications

LOVENOX® can help reduce the risk of developing DVT blood clots, which may lead
to PE, in patients undergoing abdominal surgery, hip- or knee-replacement surgery,
or in acutely ill medical patients with severely restricted mobility.

This information is intended for U.S. Healthcare Professionals.
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If you are receiving epidural or spinal anesthesia or undergoing spinal puncture,
and taking LOVENOX®, you may be at increased risk
of developing a blood clot in or around the spine, which can result in long-term
paralysis. Your risk may be further increased if you:

Take nonsteroidal anti-inflammatory drugs (NSAIDs), platelet inhibitors, or other anticoagulants, such as aspirin or blood thinners

Have an indwelling epidural catheter

Have a history of spinal trauma, or repeated spinal anesthesia or punctures

Have a history of spinal deformities or spinal surgery

It is important to contact your doctor immediately if you experience symptoms such
as tingling, numbness (especially in the lower limbs), and muscular weakness.