As part of your PD treatment with levodopa/carbidopa, it's important to take XADAGO as your healthcare provider prescribes.

Getting Started1

XADAGO is a once-daily tablet available in two dose strengths: 50 mg and 100 mg.

The recommended starting dose of XADAGO is 50 mg once daily

50 mg

After 2 weeks, your healthcare provider may decide to increase your dose to 100 mg once daily, if necessary

100 mg

Images above are not actual size of XADAGO tablets

Once-daily XADAGO can be taken with or
without food—and at any time of the day.
If you are experiencing side effects, or feel like you’re not getting the symptom relief you need, be sure to talk to your healthcare provider as soon as possible.
Do not change your dose or stop taking XADAGO unless your healthcare provider tells you to do so.

XADAGO SIDE EFFECTS1

Before taking XADAGO, tell your healthcare provider about all the medications and supplements that
you are taking. While taking XADAGO, discuss with your healthcare provider any medications you may consider starting or plan to take.

Ask your healthcare provider what medications you should not take with XADAGO1

The most common side effects when taking XADAGO include1:

Uncontrolled, sudden movements (dyskinesia)

Falls

Nausea

Trouble sleeping or falling asleep (insomnia)

What can you do about side effects?1

Ask your healthcare provider about which side effects are likely to occur and what PD symptoms you should watch for. Tell your healthcare provider if you have any side effects that bother you or do not go away.

These are not all of the possible side effects of XADAGO. For more information, call your healthcare provider for medical advice about side effects.
To report SUSPECTED ADVERSE REACTIONS or product complaints, contact US WorldMeds at 1-888-492-3246 (1-888-4XADAGO). You may also report SUSPECTED ADVERSE REACTIONS to the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

Start the conversation with your healthcare provider about XADAGO

Pay as little as $25* on your next XADAGO prescription

*Patients whose prescriptions will be paid for in part or in whole by Medicare,
Medicaid, or any similar federal or state healthcare program, are not eligible for
savings or rebates according to federal and state law.
The actual savings on your out-of-pocket costs for XADAGO
will vary according to refill quantity, personal healthcare insurance coverage,
and adherence to FDA dosing guidelines. Please review the XADAGO Prescription Savings
Program Terms and Conditions to learn more.

Reference

XADAGO Full Prescribing Information. May 2017.

Indication

XADAGO is a prescription medicine known as a monoamine oxidase type B (MAO-B) inhibitor. XADAGO is used with levodopa/carbidopa to treat adults with Parkinson's disease (PD) who are having off episodes.

Limitations of Use

XADAGO has not been shown to be effective to treat PD when taken as a single medicine (monotherapy).

Important Safety Information for Patients

Tell your physician if you are taking, or planning to take, any prescription or over-the-counter drugs.

Do not take XADAGO if you are taking other monoamine oxidase inhibitors (MAOIs), as it could cause a sudden severe increase in your blood pressure.

The combination of MAO-B inhibitors such as XADAGO and antidepressants has resulted in a serious and sometimes fatal condition called serotonin syndrome.

Do not take XADAGO with opioid medications including meperidine, tramadol, methadone, or propoxyphene, as this could result in serious, sometimes fatal, reactions.

Also, do not take XADAGO with amphetamine, cyclobenzaprine, methylphenidate, or St. John’s wort. Taking these drugs together can also result in serotonin syndrome, which could be fatal.

Do not use XADAGO with dextromethorphan, as this has been reported to cause episodes of psychosis or abnormal behavior.

Do not use XADAGO if you have hypersensitivity to safinamide, as this
can cause swelling of the tongue and mouth and trouble breathing.

You should not take XADAGO if you have severe liver disease. Do not exceed a dose of
50 mg per day of XADAGO if you have moderate liver disease.

During treatment with XADAGO you may experience increases in blood pressure.
Inform your physician if you have a history of high blood pressure. Possible symptoms of an unsafe rise in blood pressure include severe headache,
blurred vision, confusion, seizures, shortness of breath, severe anxiety, and nausea and vomiting. Contact your doctor or seek immediate
medical attention if you experience any of these symptoms.

Some patients treated with XADAGO experienced drowsiness or sudden onset of sleep.
Do not drive, operate heavy machinery, work in high places or do other dangerous activities until you know how XADAGO affects you.

Restriction of foods and beverages containing tyramine is usually not required when treated with the recommended doses of XADAGO. However,
it is recommended that you avoid foods containing high amounts of tyramine, such as aged cheeses, as some patients may have an increased
sensitivity that could lead to an unsafe rise in blood pressure.

All PD patients should be monitored for hallucinations, impulse control and confusion.

The most common side effects seen with XADAGO are uncontrolled movements (dyskinesia), falls, nausea, and insomnia.

It is not known if XADAGO is safe and effective in children

To report SUSPECTED ADVERSE REACTIONS or product complaints, contact US WorldMeds at 1-888-492-3246 (1-888-4XADAGO). You may also report SUSPECTED ADVERSE REACTIONS to the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch

Where will you XADAGO Next?

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