TREATMENT:—Symptoms usually resolve in 24 hours; deaths are rare with most treatment being supportive care.–Naloxone can reverse this in some cases and is worth a try in opioid naive children.Use between 0.4mg to 10mg with larger doses for evaluation of any effect.

10-SECOND RECAP:–clonidine overdose can happen–its an alpha-2 agonist–looks a bit like opiate toxidrome (sleepy, respiratory depression, small pupils, etc.)–narcan/naloxone might be worth a try (0.4mg IV and more PRN, titrate to effect)

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