Degenerative disc disease

BIOPHARM GmbH achieved the recombinant production of human growth and differentiation factor-5 (rhGDF-5). GDF-5 is a member of the transforming growth factor-b (TGF-b) superfamily and the bone morphogenetic protein (BMP) subfamily, and is known to influence the growth and differentiation of various tissues, including the intervertebral disc. In vitro experiments have shown that rhGDF-5 can stimulate gene expression and synthesis of the extracellular matrix proteins type II collagen and aggrecan. In vivo experiments in rabbit models of disc degeneration have shown that intradiscal injections of rhGDF-5 can stimulate an increase in disc height and hydration.

We are now looking for an opportunity to license out this product for further clinical development and commercialization.Please contact us for additional information.