David Arquette was reportedly given the boot from Justin Bieber’s 21st birthday celebration in Las Vegas after getting into a “punch-up” with the singer.

Page Six reports that the 43-year-old actor had appeared “pretty messed up” during the festivities, which took place at Las Vegas’s Omnia nightclub and are said to have raged on until 7am on Sunday morning.

According to the website, the fracas occurred in Justin’s jaw-dropping Hangover-style suite at the Nobu Hotel at Caesars Palace, with a guest reporting that the pair became embroiled in a “punch-up” after David refused to leave the party.

The eye witness reports that David, who has famously battled with sobriety and sought treatment in rehab in January 2011 for “alcohol and other issues”, was already pretty out of it by the time the afterparty got underway. They add that the fight appeared to ensue after David was overheard openly “talking about Bieber behind his back”.

“Justin heard what David had been saying, and threw him out of his suite with the help of a friend, because they didn’t have security up there,” the witness explained of the situation. “Somehow David managed to get back in and rushed at Bieber to take him out. There was a confrontation, then other people got in the way to separate them. David was thrown out again, this time for good.”

Reps for both parties have been contacted though neither has shed any light on the situation as yet.

According to Page Six, Justin was paid an eye-watering $500,000 by the Hakkasan Group to host his coming-of-age bash on Saturday night – two weeks after his actual March 1st birthday.

While it is unclear why David was even at the bash to begin with, the nightclub owner is a partner in Bootsy Bellows with the h.wood Group, which the Hakkasan Group acquired last year.