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34
JCAD JOURNAL OF CLINICAL AND AESTHETIC DERMATOLOGY December 2017 • Volume 10 • Number 12
O R I G I N A L R E S E A R C H
Group 2 (95%), Group 5 (89%), Group 4 (85%),
and Group 1 (84%). Willingness to recommend
one or more of the products to a friend was
greatest in Group 3 (97%), followed by Group
2 (95%), Group 1 (91%), Group 5 (90%), and
Group 4 (62%). The low value (62%) for Group 4,
in which both the day and night lip creams were
used, might be attributed to the lesser clinical
performance of the day lip cream in comparison
with the superior performance of the night lip
cream, as shown in Figures 15 and 16.
Among the medical estheticians, 87 percent
observed improvement in one or more of the
same attributes in their subjects.
Adverse effects. Adverse effects or
unexpected reactions of any kind were not
observed in any subject in the 56-day study or in
the experience trial.
DISCUSSION
The 56-day study. The results show that
with each of the five topical test products,
improvement in SELS becomes noticeable to the
measuring device within 15 minutes of the initial
application and that improvement continues for
at least 56 days with regular use (Table 5). To the
author's knowledge, noticeable improvement
in SELS within 15 minutes of application of
the test product is unprecedented in cosmetic
dermatology. Improvement was significant
after 14 days and 28 days of use for the day
facial cream; after 15 minutes, 28 days, and
56 days of use for the night facial cream; after
seven days and 14 days of use for the eye cream;
after seven days for the day lip cream; and after
seven, 14, 28, and 56 days of use for the night
lip cream. These results suggest that skin surface
roughness, or the depth of fine and coarse lines
and wrinkles, decreased immediately after
product application and continued to decrease
for at least 56 days with regular use of each test
product.
Similar but even more favorable trends are
apparent with EC. Improvements were significant
after 15 minutes, 14 days, and 28 days of use
for the day facial cream; after every timepoint
for the night facial cream and eye cream; and
after 15 minutes for both the day lip cream and
night lip cream. These results show that each
of the five test products helped to increase the
moisture content in the skin almost immediately
after application and that the favorable trends
continued for at least 56 days with regular use.
These very early results and continuing
improvement for at least 56 days have, to the
author's knowledge, not been reported for
any topical product. Improvement in TEWL
(measured only in those using the facial and
eye creams) was nearly immediate with the use
of the night facial cream, at 14 days with the
eye cream, and at 28 days with the day facial
cream. Improvement was significant at 28 and
56 days for the night facial cream.
The experience trial. The results (Figure
18) show that the selected products, which
included facial, eye, and lip creams, performed
FIGURE 15. A 53-year-old Caucasian woman at baseline (A) and after 56 days of treatment (B) with the day lip cream—
Pixel data (61,786 at baseline and 8,519 at 56 days) show that the wrinkles on the bottom lip were reduced by 86.21%
FIGURE 16. Changes in evaluation parameters for the night lip cream
SELS: standard evaluation parameter; EC: electroconductivity
FIGURE 17. A 46-year-old Caucasian woman at baseline (A) and after 56 days of treatment (B) with the night lip
cream—Pixel data (74,894 at baseline and 19,678 at 56 days) show that the wrinkles on the bottom lip were reduced by
73.73%.
A B
A B