The two are the same age, and are shown to be very close. They seem to trust each other's judgement, and have seen each other in some awkward, embarrassing moments. They could possibly be a good couple in the future. They like each other and one day they will marry each other.

Ever since the beginning, Francine has been jealous of Keith. She tried to use him in "Skills," but he outsmarted her. They are both drastically different, and it shows in their relationship. While it's not as strong as some of the others', they'll most likely be loathing each other for the rest of their lives.

The relationship between Keith and Manny is complicated. Keith and Manny worked together once to save an egg from dying, but Manny is also the one responsible for freezing him (Keith considers this the most embarassing moment of his life). They don't trust each other, don't like each other, and still manage to occasionally find some common ground to work on.

Not much interaction has been seen between Danny and Keith. Danny has never pulled any sort of prank on Keith and there has been no one-on-one conversations. However, the two seem to have some similarities and can get along rather well. They spent a good part of "The World is My Oyster" onstage together and Danny was the one who suggested that Keith should join the Pranksters.