The Association Between High Risk Pregnancy and Sleep-disordered Breathing

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growth and development during the 1st year of life [ Time Frame: at age 1 year ]

Original Secondary Outcome Measures

Same as current

Current Other Outcome Measures

Not Provided

Original Other Outcome Measures

Not Provided

Descriptive Information

Brief Title

The Association Between High Risk Pregnancy and Sleep-disordered Breathing

Official Title

The Association Between High Risk Pregnancy and Sleep-disordered Breathing

Brief Summary

The aim of the present study is to establish, using polysomnographic criteria and prospective nature, whether sleep apnea in pregnancy is more prevalent in women with high risk pregnancies including preeclampsia, gestational diabetes, and pre-mature contractions, and to determine the effect of sleep disordered breathing in pregnancy on fetal outcome. The investigators' hypothesis is that sleep-disordered breathing is more prevalent in women with high risk pregnancy compared to those with uncomplicated pregnancy.

Detailed Description

Over the last decade, the association between sleep disordered breathing and pregnancy outcome has been described primarily in case reports. Although recently, larger studies describing adverse pregnancy outcomes in women with sleep disordered breathing has begun to emerge, these studies often lack polysomnographic data and the true prevalence of sleep disordered breathing in pregnancy is not known. We intend to recruit 100 women at the third trimester of pregnancy, who are admitted to the high risk pregnancy unit with pre-eclampsia, gestational diabetes, or premature labor. An additional group of 50 women at the third trimester of an uncomplicated pregnancy will be recruited. All women will fill questionnaires regarding the pregnancy and their sleep and will undergo an overnight sleep study. Women will then be followed until birth. Pregnancy complication, birth and perinatal course will be recorded. Cord blood will be collected from all infants and evaluated for inflammatory cytokines, reactive oxygen species and growth factors. Infants will then be followed for 1 year. Their growth, development and intercurrent illnesses will be recorded.

Study Type

Observational

Study Design

Observational Model: Case ControlTime Perspective: Prospective

Target Follow-Up Duration

Not Provided

Biospecimen

Retention: Samples With DNA

Description:

Cord blood will be obtained in EDTA tubes and serum-seperating tubes

Sampling Method

Probability Sample

Study Population

Women in third trimester admitted to the high-risk pregnancy unit and women with uncomplicated pregnancy attending a pre-labor course

Condition

Preeclampsia

Gestational Diabetes

Premature Labor

Intervention

Not Provided

Study Groups/Cohorts

Premature labor

Women at the third trimester of pregnancy with premature contractions and cervical dilation of effacement

Control

Women at the third trimester of pregnancy with uncomplicated pregnancy

Pre-eclampsia

Women at the third trimester with pre-eclampsia

Gestational diabets

Women at the third trimester of pregnancy with gestational diabetes requiring insulin

Publications *

Not Provided

* Includes publications given by the data provider as well as publications
identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.