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1911 Excerpt: ...M. Tsuzuki. (Zeitschrift fiir Hygiene und
Infehtionshrankheiten. 1911. Mai. Ixviii. Heft 2. pp. 364-400.) The
conclusions reached are as follows--1. In the treatment of
experimental Nagana the combination of several
therapeutically-active substances acts better and produces a surer
curative effect in respect to Therapia sterilisans magna than do
larger doses of the individual components. 2. The combination of
remedies from one and the same chemical group gives less favourable
results (or curative effects) than that from different groups which
are chemically less closely related. 3. The combination of several
substances with different points of attack, in the sense of
Bhrlicu's law of distribution of medicaments and poisons, as well
as after the analogy of the action of narcotics according to Burgi,
enables us to produce sterilising mixtures which are relatively
non-poisonous to the organism as compared with the toxicity of the
sterilising dose of the individual components. 4. The best results
are obtained by the combination of at least three remedies. 5. For
the production of more certain curative effects in the Nagana of
mice a second employment of the combined remedies is indicated. 6.
The question, which remedies are suitable for combination for the
purpose of increasing the effect, can be decided for the different
species of animals and the different infections only by experiments
on infected animals. In the first nine pages of this Memoir is
given an historical account of the treatment of trypanosome
infections. The author notes that though the number.of trypanocidal
remedies is large most of the experiments in which a single drug
has been used have not brought about permanent cure, and even when
a combination has been used the results have been unsati...