..The objective of this study was to use a recently developed relative equilibrium-based graphical (RE) plot method to improve and simplify the 2 commonly used methods for quantification of (11)C-Pittsburgh compound B ((11)C-PiB) PET...

Using a reference tissue model with spatial constraint to quantify [11C]Pittsburgh compound B PET for early diagnosis of Alzheimer's disease

..For pixel-wise quantification, due to the high noise level of pixel kinetics, the parametric images generated by RTM with conventional linear or nonlinear regression may be too noisy for use in clinical studies...

..In conclusion, the new plot is a consistent and computationally efficient graphical analysis method to improve the quantification of reversible tracer binding in radioligand receptor dynamic PET studies...

..These findings provide compelling evidence that the effects of Mn on DA synapses in the striatum are mediated by inhibition of DA neurotransmission and are responsible for the motor deficits documented in these animals...

Sex differences in striatal dopamine release in healthy adults

Cynthia A MunroDepartment of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USABiol Psychiatry 59:966-74. 2006

..Sex differences in addictive disorders have been described. Preclinical studies have implicated the striatal dopamine system in these differences, but human studies have yet to substantiate these findings...

Mechanisms of dopaminergic and serotonergic neurotransmission in Tourette syndrome: clues from an in vivo neurochemistry study with PET

..The finding of decreased SERT BP, and the possible elevation in 5-HT2AR in individuals with TS who had increased DA rel, suggest a condition of increased phasic DA rel modulated by low 5-HT in concomitant OCD...

VMAT2 and dopamine neuron loss in a primate model of Parkinson's disease

..The results are consistent with preclinical findings showing an interrelationship between glucocorticoids and mesolimbic DA dynamics, which may influence psychostimulant self-administration in humans...

Striatal dopamine release and family history of alcoholism

Cynthia A MunroDepartment of Medicine, The John Hopkins University School of Medicine, Baltimore, Maryland 21205, USAAlcohol Clin Exp Res 30:1143-51. 2006

..The strong associations of PiB retention with region-matched, quantitative analyses of Aβ in postmortem tissue offer support for the validity of (11)C-PiB-PET imaging as a method for evaluation of plaque burden in vivo...

Lack of association between 11C-PiB and longitudinal brain atrophy in non-demented older individuals

..For PET, distribution volumes (DVs) were 1.38 then 0.87 pre- and postblocker (PMPA). Little metabolism of 11C-MCG occurred in the mouse or baboon. These results suggest that 11C-MCG may be useful for imaging GCP II in the periphery...

Correlation of the vesicular acetylcholine transporter densities in the striata to the clinical abilities of women with Rett syndrome

James Robert BrasicThe Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Maryland 21287 0807, USASynapse 66:471-82. 2012

..I]IBVM is a promising tool to characterize the pathophysiological mechanisms of RTT and other neurodevelopmental disabilities...

..In this article we compare the performance of a simple alternative to GSEA. We find that this simple solution clearly outperforms GSEA. We demonstrate this with eight different microarray datasets...

Accelerating the optimization of requantization codebook for vector quantization

..All these features pave the way toward real-time variable-rate data compression and transmission over heterogeneous networks. Simulation results support the theory and the advantages of our method...

Lynn M OswaldDepartment of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, MD 21205, USANeuroimage 36:153-66. 2007

..No associations were observed between impulsivity or stress and cortisol responses to AMPH. The findings are consistent with notions that blunted DA responses represent an endophenotype for substance use disorders...

Quantification of D2-like dopamine receptors in the human brain with 18F-desmethoxyfallypride

..To find the relationship between the clinical manifestations of dysphagia resulting from stroke and dysfunction of swallowing organs. It is helpful to understand the mechanism of dysphagia so as to guide its diagnosis and therapy...

Up-regulation of IL-10 expression in dendritic cells is involved in Trichosanthin-induced immunosuppression