The parents of Alfie Evans have lodged an application to appeal to the Supreme Court in a final attempt to save their son’s life.

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Tom Evans and Kate James this week lost an appeal against a High Court decision that Alfie be taken off his ventilator.

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On Tuesday, judges at The Court of Appeal, upheld the decision made by the High Court that Alder Hey Children’s Hospital should be allowed to stop providing treatment to the brain damaged 21-month-old.

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The three Court of Appeal judges ruled that continued ventilation was not in the best interests of the toddler.

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However, his parents, were told they could work with Alder Hey on deciding a timescale for the withdrawal of life support and end-of-life care.

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Alfie’s parents had hoped to overturn the high court verdict and keep up the search for treatment by moving their son to another hospital overseas.

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But the Liverpool children’s hospital argued all possible treatments had already been exhausted for his mystery brain condition.

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However, today the couple have lodged an application to be able to appeal against the decision to the Supreme Court.

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The Supreme Court is the final court of appeal in the UK for civil cases, and for criminal cases from England, Wales and Northern Ireland.

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It hears cases of the greatest public or constitutional importance affecting the whole population.

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If that appeal was to fail, Alfie’s parents only other option would be to take their fight to the European Court of Human Rights.

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A spokesman for Alder Hey said: “The Supreme Court will now consider the application to appeal the decision of the Appeal Court.

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“Our priority is to continue providing Alfie with the best care possible.”

The parents’ battle has attracted attention and support around the world, with tens of thousands of people forming “Alfie’s Army” to rally behind them.

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Before the appeal hearing Mr Evans, 21, from Bootle, had said “he would not give up his fight to keep his son alive”.

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