Definition: Bera is an objective way of eliciting brain stem potentials in response to audiological click stimuli. These waves are recorded by electrodes placed over the scalp.Thisinvestigation was first described by Jewett and Williston in 1971.

Even though BERA provides information regarding auditory function and sensitivity, it is not a substitute for other methods of audiological evaluation. It should be always viewed in conjunction with other audiological investigations.

Procedure: The stimulus either in the form of click or tone pip is transmitted to the ear via a transducer placed in the insert ear phone or head phone. The wave froms of impulses generated at the level of brain stem are recorded by the placement of electrodes over the scalp.

Electrode placement: Since the electrodes should be placed over the head, the hair must be oil free. The patient should be instructed to have shampoo bath before coming for investigation. The standard electrode configuration for BERA involves placing a non inverting electrode over the vertex of the head, and inverting electrodes placed over the ear lobe or mastoid prominence. One more earthing electrode is placed over the forehead. This earthing electrode is important for proper functioning of preamplifier.

Figure showing placement of BERA electrodes

Since thepotentials recorded are in far field, well displaced from the site of impulse generation, the wave forms recorded are very weak and they need to be amplified. This amplification is achieved by improving the signal : noise ratio.

How to improve signal to noise ratio: Three parallel approaches are designed to achieve this goal.

Filtering: This is employed to reduce the recording bandwidth so that only the important components of the siganal generated are recorded.

Repeated stimulation: This is done with synchronous time domain averaging to increase the amplitude of the components of the signal. In real time situations these two can be achieved by connecting the recording electrodes to a preamplifier, with appropriate filter settings.

Polarity alteration: By altering the polarity of impuses recorded, the artifacts are cancelled making the brain stem waves stand out.

In auditory brain stem evoked response audiometry, the impulses are generated by the brain stem. These impulses when recorded contains a series of peaks and troughs. The positive peaks (vortex positive) are referred to by the Roman numerals I - VII.

These peaks are considered to originate from the following anatomical sites:

1. Cochlear nerves - waves I and II

2. Cochlear nucleus - wave III

3. Superior olivary complex - wave IV

4. Nulclei of lateral lemniscus - wave V

5. Inferior colliculus - waves VI and VII

These peaks occur in most readable form in response to click stimuli over a period of 1 - 10 milliseconds after the stimulus in normal hearing adults.

BERA is resistant to the effects of sleep, sedation, sleep and anesthesia. Its threshold has been found to be within 10dB as elicited by conventional audiometry.

Illustration showing various wave forms of BERA

There are two different types of auditory evoked potential tests. These tests are being used as an adjunct to routine diagnostic testing. The two types of auditory evoked potential tests are: 1. Auditory brain stem response and 2. Auditory cortical response.

Auditory cortical response: Records the impulses generated by brain in response to tone stimuli. It is recorded using cortical response audiometry (CERA). CERA is very useful for threshold estimation of hearing, where as BERA is highly useful for objective threshold estimation of hearing as well as differential diagnostic purposes. These reponses are more generalised and originate form the brain cortex occurring between 50 - 300 milliseconds after the onset of stimulation. Since these responses are generally elicited with a tone burst lasting approximately for about 200 milliseconds, its responses are highly frequency specific.This is in contrast to BERA because brain stem responses are evoked by click stimuli and are not frequency specific. Interpretation of CERA is easy and straightforward. Threshold is defined as the minimum stimulus level that gives a consistent and identifiable response.The patient must be lying still during the recording process. This test is hence unsuitable for young children who may not co-operate

Differences between BERA and CERA

BERA

CERA

Recording is made from brain stem potentials

Recording is made from cortical potentials

Click stimulus is used

Tone stimulus is used

Responses are not frequnency specific

Responses are frequency specific

Can be performed in awake and restless patients

The patient must lie still through out the process

Responses begin after 1 - 10 milliseconds after stimuli

Response begins after 50 - 300 milliseconds after stimulation

Suitable for even young children

Unsuitable for children

Uses of BERA:

1. It is an effective screening tool for evaluating cases of deafness due to retrocochlear pathology i.e. (Acoustic schwannoma). An abnormal BERA is an indication for MRI scan.

2. Used in screening newborns for deafness

3. Used for intraoperative monitoring of central and peripheral nervous system