ASPP1 Antibody

The Apoptosis-Stimulating Protein of P53 (ASPP) family of proteins is comprised of ASPP1, ASPP2 and iASPP. 53BP2 is now recognized to be the C-terminal 528 amino acids of ASPP2. ASPP1 and ASPP2 function to direct the cell away from cell cycle arrest and towards death by activating p53 family members, while iASPP functions to inhibit p53 mediated apoptosis. ASPP proteins have been shown to interact with p53, Bcl-2, and ReLA/p65.