Given the energy signature variance, it appears Isotope-8 may have varieties that create different enhancement effects.
If I'm correct, then even the weakest opponent could match our strongest heroes with enough exposure to this.
However, even those with super-powers can also benefit.
If we can recover more, even the Hulk could be made more powerful--as unlikely as that seems.

Tony Stark:

Got it. We need more of this stuff... bad guys need less of it.

Nick Fury:

Keep your eyes open for more Isotope-8. It might give us the edge we need.

Agent, you're back in the field as of now. I've got a two-part briefing.

One, there's a jailbreak at Ryker's. It appears to be centered on the Raft, but regular inmates are being used as cover.
Two, take a look at this. We got a coded anonymous message. Reed broke it, and...

Mr. Fantastic:

This is more than a jailbreak. You're going to find a couple of unexpected inmates when you run these coordinates.

There was a strange meteor impact around the last time we fought the Living Monolith. It's set apart from ordinary planetary collisions because the falling body doesn't match known trajectories of any near-Earth objects.

Another anomaly is the lack of objects at the impact site, despite having visual evidence of the path through the atmosphere.
Narrowing down points of origin and current location will require some lab time. Let me see what I can do.