Trevor and Ron drive to McKenzie Airfield in Grapeseed where Trevor takes control of a Duster aircraft. Trevor flies towards a Merryweather cargo plane circling near Fort Zancudo. In order to avoid the fort's radar, Trevor must keep the Duster low to the ground as he approaches the plane and as he follows it along the northern shore of San Andreas. Once Trevor clears the fort's airspace, he approaches the cargo plane.

As Trevor nears the plane, Merryweather mercernaries order him to move away. Eventually, they open the plane's rear cargo bay doors and begin shooting at him. Trevor crashes the Duster into the cargo bay, then fights his way past Merryweather mercernaries and sliding Merryweather Mesas to the plane's cockpit where he kills the pilot. Trevor takes control of the aircraft and attempts to fly it back towards McKenzie Field. However, he is soon intercepted by two US Air ForceP-996 LAZER jets which demand that Trevor land at Fort Zancudo. Trevor refuses, resulting in the LAZERs firing missiles at the cargo plane and destroying one of its engines. Forced to bail out, Trevor jumps from the still open cargo doors and parachutes to safety. The plane crashes into the Alamo Sea.

After the mission, Amanda De Santa calls Franklin to ask about Michael's situation.

If the player doesn't pull the cargoplane up and allows the jets to fly alongside, a brief cutscene will play, where the fighter pilot and Trevor exchange hand signals. This may be similar to the hand signals exchanged between Andreas Prodromou, a flight attendent, and the pilot from the Hellenic Air Force in the Helios Airways Flight 522 air disaster. The hand gestures from the crash can be seen here .

After the Cargo plane's engines are shot, and the player has to jump out of the plane, the plane is actually staying in one place, simply rocky around for realism as if it is moving. If you head towards the edge of the plane without falling out, it will trigger the plane to start heading towards the Alamo Sea. However, it is impossible to stay in the plane when it is falling.

The cutscenes to nearing the ending and the actions are loosely similar to the ending of the movie Air Force One (1995).