Definitely. Immediately came to mind as soon as I started seeing him roll around. Frost King Malakk also says "Winter is coming", most likely a GoT reference.

The generalist looks outward; he looks for living principles, knowing full well that such principles change, that they develop. It is to the characteristics of change itself that the mentat-generalist must look. There can be no permanent catalogue of such change, no handbook or manual. You must look at it with as few preconceptions as possible, asking yourself, "Now what is this thing doing?"-Children of Dune

Not only is Primordius - Gollum, the first time we were on him, after hitting a wall on Durumu for a week or so, we 1-shot him. The reaction at the end of the Primordius fight was.... I have no idea what just happened, but hooray free loot! (Spazz of a boss that one)