... AMSTERDAM November 28 /- Kiadis Pharma announced tod...According to the NHLBI investigators the challenge in the field ofall...The investigators have published the preclinical data showing promisin...For the complete press release go to A HREF http://www.kiadis.com/Ne...

AMSTERDAM, November 28 /PRNewswire/ -- Kiadis Pharma announced today
the presentation of the results obtained so far in the physician initiated
study led by Dr. Stephan Mielke* and Dr. John Barrett* of the National
Heart, Lung, and Blood Institute (NHLBI) a department of the National
Institutes of Health (NIH) on Kiadis' lead product ATIR at the AABB annual
meeting & TXPO 2007 in Anaheim, California.

According to the NHLBI investigators the challenge in the field of
allogeneic bone marrow transplantations lies with disease control, Graft
versus Host Disease (GvHD) control and donor availability. Doctors Barrett
and Mielke have focused on controlling GvHD whilst sparing the Graft versus
Leukemia (GvL) effect and also on increasing donor availability.

The investigators have published the preclinical data showing promising
results with Kiadis Pharma's ATIR in eliminating alloreactive T cells from
donor grafts (Mielke et al. Blood, 2007). These results have led to the
start of a phase II study with ATIR by the NHLBI. This trial is designed to
demonstrate that ATIR treatment may overcome the need of immunosuppressant
prophylaxis post transplantation. Prophylaxis is currently standard
practice to prevent GvHD, but has a serious drawback, as it increases the
chance of infection and also the relapse rate. Thus ATIR does not only
intend to prevent GvHD, but could also reduce the rates of infection and
relapse. Together, these complications account for approximately 70 % of
allogeneic transplant related mortality.

Dr John Barrett is Chief of the Allotransplant Section at National
Heart, Lung, and Blood Institute (NHLBI) of National Institutes of Health
(NIH) in Bethesda, MD, USA, where the trial is being performed. Dr Stephan
Mielke, who initiated this study as principal investigator at NHLBI, is
currently worki'/>"/>

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