In April 2016, Heidelberg University’s newly founded open access publisher heiUP launched the first volume of the new book series Heidelberg Studies in Transculturality.

This article reports on the challenges, accomplishments, and setbacks that informed the entire editorial production process, not only of the first volume but also of the series and the publishing enterprise overall.

The authors offer insights on crucial issues that any new open access publishing endeavour at an institution might face, namely acquiring manuscripts, designing and building workflows, and collaborating with partners to build an outlet for hosting the finished product.

This article also illustrates how the goal of providing a new digital reading experience through an innovative HTML format, in addition to print-on-demand and PDF versions of each manuscript, affected the progress of the entire project. Finally, we report on what it took to deliver results.