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Symptoms, which generally occur after sudden standing, include dizziness, lightheadedness, headache, blurred or dimmed vision (possibly to the point of momentary blindness), and fainting. It can be caused by blood pooling in the lower extremities; venous return and cardiac output are further compromised, resulting in further lowering of arterial pressure.

When orthostatic hypotension is caused by hypovolemia due to medications, the disorder may be reversed by adjusting the dosage or by discontinuing the medication. When the condition is caused by prolonged bed rest, improvement may occur by sitting up with increasing frequency each day. In some cases, physical counterpressure such as elastic hose or whole-body inflatable suits may be required. Dehydration is treated with salt and fluids.

The prognosis for individuals with orthostatic hypotension depends on the underlying cause of the condition.