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What's "best" is a matter of opinion. I use Windows Defender and have never had a virus or malware. I occasionally scan with Malwarebytes but it never finds anything. Frankly, the best defense is safe surfing practices.

There is no universal "one size fits all" solution that works for everyone and there is no single best anti-virus. Every vendor's virus lab and program scanning engine is different. Each has has its own strengths and weaknesses and they often use a mix of technologies to detect and remove malware. In many cases choosing an anti-virus is a matter of personal preference and what works best on a particular system. You may need to experiment and find the one most suitable for your needs. Please read: