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Bill Gates is hoping the human race can make it through the next decade without any serious epidemics because otherwise we could be in a bit of trouble, he says.

The billionaire Microsoft founder turned disease-fighting philanthropist dedicates his time to eradicating diseases such as malaria, tuberculosis and others.

But while he has enjoyed commendable success in that pursuit, he has his doubts about how the world can handle a potential pandemic.

"There's a lot of discussion right now about how do we respond in an emergency, how do we make sure the regulatory, and liability, and organisational boundaries don't slow us down there," he told BBC Radio 4 prior to the New Year.

"So I cross my fingers all the time that some big flu epidemic doesn't come along in the next 10 years."

Given the world's clunky response to the outbreaks of Ebola and the Zika virus recently, Mr Gates has his concerns about the planet's ability to successfully defend against a major epidemic - something that is certainly not out of the question given increasingly urgent threat of antibiotic resistant superbugs.

"I do think we'll have much better medical tools much better response (in the future) but we are a bit vulnerable right now if something spread very quickly like, say a flu that was quite fatal," he said.

"That would be a tragedy."

In 2014 Mr Gates and his wife Melinda pledged $US500 million ($721.8 million) to tackle infectious diseases in developing countries. They believe such work is critical in reducing instances of disease everywhere.

"The ebola epidemic has shown, once again, that in today's interconnected world, health challenges anywhere create health challenges everywhere," the Gates foundation said in a press release at the time.