POT1 (zeige POT1 Antikörper)-TPP1 (zeige TPP1 Antikörper) binds telomeric DNA in a coordinated manner to facilitate assembly of the nucleoprotein complexes into a state that is more accessible to enzymatic activity.

The presence of dysfunctional telomeres in chronic lymphocytic leukemia did not correlate with telomere shortening or chromatin marks deregulation but with a down-regulation of 2 shelterin genes: ACD and TINF2 (zeige TINF2 Antikörper).

Results support a model in which POT1 (zeige POT1 Antikörper)-TPP1 (zeige TPP1 Antikörper) enhances telomerase processivity in a manner markedly different from the sliding clamps used by DNA polymerases.

ACD Antigen-Profil

Beschreibung des Gens

This gene encodes a protein that is involved in telomere function. This protein is one of six core proteins in the telosome/shelterin telomeric complex, which functions to maintain telomere length and to protect telomere ends. Through its interaction with other components, this protein plays a key role in the assembly and stabilization of this complex, and it mediates the access of telomerase to the telomere. Multiple transcript variants encoding different isoforms have been found for this gene. This gene, which is also referred to as TPP1, is distinct from the unrelated TPP1 gene on chromosome 11, which encodes tripeptidyl-peptidase I.