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Lee joined TCS (predecessor of MediaCorp) after winning the biannual Star Search in 1993.

At the Star Awards 2006, Lee was awarded the Best Actress award for her role as a lawyer in the drama serial Family Matters. Before that, she was also crowned for the Best Actress another two times. The first in 2000, and then in 2004. That was a feat only matched by fellow actress Huang Biren (However, Huang still wins if nominations for Asian Television Awards are taken into account).

Later in her career, Lee was known for her partnership with veteran actor Edmund Chen, most notably in Beyond the Axis of Truth and Double Happiness. At the Star Awards 2007 anniversary special celebrating 25 years of Chinese drama in Singapore, they were named one of the Top 5 Favourite On-screen Partners for their roles as husband and wife in Double Happiness.

Lee left the entertainment industry in November 2009 and moved to Hong Kong with her family.

Lee lives in Hong Kong with her four children and her director husband, who is from Hong Kong. In 2005, Lee gave birth to a pair of twin sons. She also has a daughter (now 13 years old as of 2010) prior to the twin sons. In 2009, she gave birth to yet another baby girl (her 4th child). She had relocated to Hong Kong with her children to be nearer to her husband as he travels frequently within China.[1]