Developed by:

Purpose:

You may use this R code for fitting the Random Periods Model (RPM) for cell cycle genes. Since outliers and influential observations are not uncommon, the parameters of RPM are estimated using the L_1 norm. The RPM is a nonlinear model that can be used to model the expression of a cell-cycle gene over time. For details regarding the model one may refer to Liu et al. (2004).