I am primarily interested in host-pathogen interaction, with a focus on vector-borne RNA viruses in vivo and in vitro. Specifically, I wish to understand pathogenic mechanisms of viral infection at the cellular and animal levels, and study the molecular function of host genes that influence viral pathogenesis and the disease outcomes. On the host side, I am keen on the innate immune system, detection of viruses and initiation of antiviral immune responses. On the viral side, I wish to understand the mechanisms of immune evasion. My recent work is focused on the RIG-I like receptor signaling pathways and their regulation, the physiological functions of NOD-like receptors in limiting West Nile virus/Chikungunya virus infection, and the unappreciated functions of UBXNs in immune regulation.