This means that most Vorta do not view death as most humanoid species do and faced it with arrogance. They were also equipped with a "kill switch" that they could trigger to commit suicide. This was mainly a system to stop important Vorta from falling into the hands of the Founders enemies. Most Vorta when faced with capture would kill themselves knowing that a new clone would soon be released to continue their service to their gods. (DS9: "Treachery, Faith and the Great River")

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When the morphogenic virus created by Section 31 killed nearly all the Founders in the late 2370s, the Jem'Hadar committed mass suicide, taking most of their Vorta overseers with them. Only a handful of Vorta survived, and most of the Dominion's cloning facilities were destroyed. (Star Trek: Pendragon: "Shadows of the Fire")