Acetaminophen is extensively used as an analgesic and antipyretic agent, but at high doses it causes liver damage. The major metabolic pathways of acetaminophen are glucuronidation and sulfation. In addition to these pathways, acetaminophen...

The ability of embryonic stem cells to give rise to all cells comprising the three germ layers – endoderm, mesoderm and ectoderm – highlights a powerful in vivo system for the study of early embryonic development. Human embryonic stem cell (hESC)...

Cell migration is an essential part of many processes including embryonic development, wound healing, and unwanted processes like metastasis. Further study of cell migration is needed to help understand these processes. A cell model system (F9...

The ability of cells to migrate is important for development, neurite formation,
immune function, and other processes necessary for the life of an organism. However,
the gaining of an inappropriate migratory function, as well as, uncontrolled...

Cell Migration is an integral part of normal biological development and biological processes, but also plays an important role in pathogenic processes including the progression of cancer towards metastasis. The mechanisms that regulate cell...

Repeated exposure to addictive drugs causes unmistakable changes to occur on both a neuronal and a behavioral level. Certain circuits in the brain of an addict are forced to change and adapt to an environment of drug-induced chemical imbalance....

Comfrey is an herb traditionally used for bone healing. It is also sold as a dietary supplement to promote respiratory health. Comfrey has been banned in Canada and Germany because of its link to liver damage or failure, but remains legal in the...

Cyclin D1 is the major regulator of cell cycle --- the division of cells to copy themselves. Cyclin D1 is the product of ccnd1 gene and plays an important role in regulation of cell cycle transition from G1 phase to S phase. The cell cycles of...

Transforming growth factor-alpha (TGFa), a member of the endothelial growth
factor (EGF) family of mitogens, was previously thought to exist solely in neoplastic
cells and the quickly dividing cells of a developing fetus. Since then, TGFa...

Our lab has recently observed a triphasic hypertonicity induced current in stage IV-VI Xenopus laevis oocytes. This current is a calcium-dependant chloride current which is similar to that observed by (Hartzell, 1996). Hartzell, 1996) found that...

During the last decade, new technologies created a deluge of potential drug targets. Sifting through thousands of potential drug targets is a major industry bottleneck. Pharmaceutical companies can save billions of dollars by identifying most...

The autosomal recessive mshi mutation in BALB/cBy mice phenotypically causes reduced testis size and male sterility in homozygotes. The development of the mshi male generative organs, prior to three weeks of age, appears to lack observable...

Myogenesis is an important process that occurs during the developmental stages of an embryo. Stem cells learn of their fate during this course if they will become muscle cells and from there, differentiation within those muscle cells will take...

"Submitted in Partial Fulfillment of the Requirements for the Degree of Master of Arts in Biomolecular Science."; Thesis advisor: Cheryl Watson.; M.A.,Central Connecticut State University,,2013.; Includes bibliographical references (leaves 29-33).

"Submitted in Partial Fulfillment of the Requirement for the Degree of Master of Arts in Biomolecular Science."; Thesis advisor: Michael Davis.; M.A.,Central Connecticut State University,,2012.; Includes bibliographical references (leaves 42-45).

Receptor-mediated endocytosis as a route of gene delivery shows promise as it is a natural cellular process and allows targeting of ligands to specific cells. A carrier system consisting of two important components: a targetable ligand,...

This research examines the internal and external root causes of terrorism by providing an in depth study of al-Qaeda. After more than ten years of fighting, the war on terror the threat from al-Qaeda still remains. Al-Qaeda cells around the world...

"Submitted in Partial Fulfillment of the Requirements for the Degree of Master of Science in Biological Sciences."; Thesis advisor: Jeremiah Jarrett.; M.S.,Central Connecticut State University,,2014.; Includes bibliographical references (leaves...