Not tested in other applications. *Optimal dilutions/concentrations should be determined by the researcher.

Predicted Target Size

98 kDa (note)

Positive Controls

THP-1 , NCI-H929

Form Supplied

Liquid

Concentration

1
mg/ml
(Please refer to the vial label for the specific concentration)

Purification

Purified by antigen-affinity chromatography.

Specifications: TLR5 antibody

Full Name

toll-like receptor 5

Product Description

Rabbit Polyclonal antibody to TLR5 (toll-like receptor 5)

Background

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene product is expressed in myelomonocytic cells, and recognizes bacterial flagellin, a principal component of bacterial flagella and a virulence factor. The activation of this receptor mobilizes the nuclear factor NF-kappaB and stimulates tumour necrosis factor-alpha production. [provided by RefSeq]