During the past several decades, increasingly complex health care technologies, such as dialysis, monitoring devices, home ventilators, ventricular assist devices, enteral tube feedings, and wound vacuums, have moved to the home. One commonly used technology in the home, outpatient parenteral antimicrobial therapy (OPAT), provides a way for patients needing long-term antimicrobial therapy to leave the hospital (or avoid the hospital altogether) and receive antibiotic agents through central venous catheters (CVCs).