Immune Response Template (IRT)

is a Quantitative Systems Pharmacology (QSP) platform of immune system and tool for development of QSP and mechanistic models related to immune response.

IRT consist of IRT Database and IRT Navigator. The core of IRT Database is IRT Core Model, a QSP model of immune system. IRT Navigator is an application software providing intuitive interface to work with IRT Database. IRT is an innovative tool allowing users to select all or any reactions and species from IRT Core Model and download it.

To learn more about IRT please sing up and try demo.

To purchase access to the full version of IRT please contact us by email: irt@insysbio.com

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Latest version

Version 2.1.0. (release date: 2018-11-22)

Updates

IRT Database UPDATE! MDSC (schemes, equations, parameters, annotation): (1) revision of regulation of Mo-MDSC and Gr-MDSC maturation and generation by cytokines; (2) revision of regulation of apoptosis of Mo-MDSC and Gr-MDSC; (3) identification of parameters of cytokines’ effect on MDSC maturation and apoptosis on the basis of in vitro and in vivo data; (4) update of summary of data analysis on MDSC.

IRT Database UPDATE! correction of errors

IRT Core Model characteristics

704 reactions

350 time dependent variables

504 parameters - about 24% of parameters are identified

308 published articles are used in the IRT as references including 93 research articles from which data were extracted and used for identification of parameters or initial values of variables.

Previous versions

Version 2.0.0. (release date: 2018-09-26)

Updates

General UPDATE! online access to the IRT

General UPDATE! continuous update of IRT Database: significant updates (new schemes, players, in vitro models, etc) 2-3 times per year + regular small updates (identification of new parameters, addition of new data, etc).

Differentiation of macrophages in different types (M1, M2a, M2b, M2c);

IgG production by plasma cells;

Cytokines production by different types of the cells;

Differentiation of naïve CD4 T cells in Th1, Th2, Th17 and Treg cells;
All these processes are regulated by cytokines and surface receptors.

IRT Core Model characteristics

291 reactions

79 time dependent variables

310 parameters - about 30% of parameters are identified

about 200 published articles are used in the IRT as references including about 80 research articles from which data were extracted and used for identification of parameters or initial values of variables.