Basis for original (SCP) IDLH: According to ACGIH [1971], the critical rodenticidal dosages of Pival® (pindone) and warfarin are similar. Therefore, the chosen IDLH is based on an analogy with warfarin which has an IDLH of 200 mg/m3.

Short-term exposure guidelines: None developed

ACUTE TOXICITY DATA:

Lethal dose data:

Species

Reference

Route

LD50 (mg/kg)

LDLo (mg/kg)

Adjusted LD

Derived value

RatDog

Rabbit

Gaines 1960Klimmer 1971

Perkow 1971/1976

oraloral

oral

28075

150

———-

—–

1,960 mg/m3525 mg/m3

1,050 mg/m3

196 mg/m353 mg/m3

105 mg/m3

Other animal data: It has been reported that the critical rodenticidal dosages of Pival® (pindone) and warfarin are similar [ACGIH 1971].

Human data: It has been reported that 50 to 500 mg/kg is the probable lethal oral dose [Gosselin et al. 1984]. [Note: An oral dose of 50 to 500 mg/kg is equivalent to a 70-kg worker being exposed to about 2,330 to 23,300 mg/m3 for 30 minutes, assuming a breathing rate of 50 liters per minute and 100% absorption.]

Revised IDLH: 100 mg/m3Basis for revised IDLH: No inhalation toxicity data are available on which to base an IDLH for pindone. Therefore, the revised IDLH for pindone is 100 mg/m3 based on acute oral toxicity data in humans [Gosselin et al. 1984] and animals [Gaines 1960; Klimmer 1971; Perkow 1971/1976] and an analogy to warfarin [ACGIH 1971] which has a revised IDLH of 100 mg/m3.