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The purpose of this study is to develop Positron Emission Tomography (PET) - Computed Tomography (CT) PET/CT imaging methods for looking at the effects of chemotherapy in breast cancer.

Criteria for eligibility

Healthy Volunteers: No

Maximum Age: N/A

Minimum Age: 18 Years

Gender: Female

Criteria: Inclusion Criteria:

- Subjects must have histologically proven breast cancer

- Subjects are being considered for preoperative chemotherapy

- Subjects must be ≥ 18 years old.

Exclusion Criteria:

- Children will be excluded from this study.

- Pregnant women and women who are breast feeding will be excluded from this study. (The "PET Procedure Screening Form" will be used to identify and exclude subjects who are pregnant or breastfeeding. A urine pregnancy test/or serum beta HCG will also be performed for women of child bearing potential)

- Patients who are acutely ill who are deemed by their treating physician as not suitable candidates for this study