With my 7520 I had it set up to enclude my Gmail, hotmail, and nextel 870 as 3 other options other than my default reply to email and it worked fine.

Now I type a message, and before I send it, I push in the thumb wheel, and select "reply to: Gmail" or hotmail and they still go to my original default reply to address.

I tried wiping away all my Pocket day reply too settings. Doing a radio reset, a hard power cycle, and then entering them in again. But nothing.
I tried deleting bbreply app, thought that was conflicting, still no fix.

When you select the reply-to address on the email menu, do you see the reply-to address show up at the top of the email that you are composing? If so, then it's probably because you don't have the reply-to address on the web client blacnk. This is a requirement.

Yes, Just before I am ready to SEND the email, I push in the thumb wheel, and go to Reply To: then selecet either Gmail, or Hotmail. And both of those I have indicated inside Pocketday's Reply to settings.

I am on a BES, but even before with the 7520, my default reply to address was set as something like and then if I ever wanted anything else, I would use Pocketday to determine which one I wanted the mail to come back to.

Webclient is not blank where it says default reply to address, it has the one that i'd like as default unless otherwise specified.

On a BES environment you have the option of sending the email two ways: from the BES server or from the web client. If you send via BES it will have the proper compnay email address. If you send from the web client it will have what you specify from pocketday as the reply to. When you reply to an email you can change the From by changing the address at the top of the email screen.