Abstract

Since the initial report by Cooke, Dunphy and Blake1 of an infant treated successfully with streptomycin for tuberculous meningitis, numerous individual case reports have appeared. The fact that many of these reports have described arrest of the disease without prolonged follow-up has created an impression of optimism.

More extensive series have tempered this initial enthusiasm. Hinshaw, Feldman and Pfuetzer2 reported nine cases of tuberculous meningitis, of whom two had completed six months of treatment and had continued to improve two and three months after the cessation of therapy. In a report to the Council on Pharmacy and Chemistry3 of 91