Mental illness link

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This approach made it possible to evaluate the genetic risk of diseases such as schizophrenia and bipolar disorder up to six times more accurately than with traditional analysis of known genetic risk variants, according to studies led by Mark Gerstein.

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Differences in cell types between 16 regions of the brain during development may play a major role in determining whether people with genetic risk actually develop a neuropsychiatric disorder, according to researchers in the lab of Dr. Nenad Sestan, a professor of neuroscience, comparative medicine, genetics and psychiatry at Yale.

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FRIDAY, Dec. 14, 2018 -- Researchers say a massive genetic analysis of the human brain has yielded new insights into the underpinnings of psychiatric diseases such as schizophrenia, bipolar disorder and autism.

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These periods of significant changes in brain development are when genes associated with the risk of neuropsychiatric disorders tend to form distinct networks in certain brain areas, according to the investigators.

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Gerstein and his colleagues also found these genetic risk variants can influence the function of genes very early in development and throughout life, but they have a greater chance of causing symptoms during different stages of brain development.