This study performs HLA matched stem cell transplantation from unrelated donors in adults who require stem cell transplantation but do not have a matched related donor available. The incidence of graft-versus-host disease in unrelated stem cell transplantation is recorded. This study also monitors the activity and toxicity of total body irradiation and cyclosphosphamide followed by stem cell transplantation from matched unrelated donors.

Further study details as provided by University of California, San Francisco:

Estimated Enrollment:

30

Study Start Date:

January 1999

Study Completion Date:

June 2009

Primary Completion Date:

June 2009 (Final data collection date for primary outcome measure)

Detailed Description:

This protocol identifies a standard-of-care method for unrelated stem cell transplantation in adults. Performing this service in a consistent and documented fashion allows investigators to obtain informed consent from recipients. Data is tabulated locally for quality-control comparisons with nationally-reported standards. As a condition of maintaining transplant center status and to have acess to NMDP-registered donors, UCSF submits clinical and outcome data to the NMDP. As a result, UCSF is contributing to the resolution of remaining uncertainties regarding particular transplantation practices.

Alkaline phosphatase and AST must be less than three times the upper limit of normal

Negative serology for the human immunodeficiency virus

Available HLA-matched donor

Signed informed consent

Exclusion Criteria:

No fully or single-antigen-mismatched sibling donor is available to donate stem cells

No active liver disease.

Contacts and Locations

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To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below.
For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00511537