The Kimmelman Lab located at the Dana Farber Cancer Institute, Harvard Medical School in Boston, Massachusetts is focused on the study of pancreatic cancer. As the fourth leading cause of cancer death in the United States, pancreatic cancer is highly refractory to all forms of treatment and novel approaches are urgently needed. Our lab is focused on understanding the complex biology of this deadly cancer to develop novel therapeutic approaches as well as to promote response to exisiting agents such as chemotherapy and radiation. Specifically, we have taken a comprehensive approach to study the altered cellular metabolism of pancreatic cancers.