5 Feb 1942 USS Pike (Lt.Cdr. W.A. New) left Darwin for her third war patrol.

28 Mar 1942 USS Pike (Lt.Cdr. William Adolph New) ended her third war patrol when she returns to base at Fremantle, Australia.

19 Apr 1942 USS Pike (Lt.Cdr. W.A. New) leaves Fremantle for her 4th war patrol. She was to patrol north of the Palau Islands and off Wake Island.

25 May 1942 USS Pike (Lt.Cdr. W.A. New) ended her 4th war patrol when she returned to base at Pearl Harbor.

30 May 1942 USS Pike (Lt.Cdr. W.A. New) leaves Pearl Harbor for her 5th war patrol. She was ordered to patrol north of Oahu.

9 Jun 1942 USS Pike (Lt.Cdr. William Adolph New) ended her 5th war patrol when she returned to Pearl Harbor, and was sent to the Mare Island Naval Yard for an overhaul.

14 Jan 1943 During her 5th war patrol USS Pike (Lt.Cdr. William Adolph New) guided bombers to Wake Island in December 1942, but on 14 January 1943 she was damaged by bombs and depth charges off Ichie Saki, southern Honshu, Japan. due to this damage the patrol is aborted and returns to port.

31 Mar 1943 USS Pike (Lt.Cdr. Louis Darby McGregor, Jr.) left Pearl Harbor for her 6th war patrol, and was to patrol in the Caroline Islands area.