Depressions physical source discovered; potential for new treatments

Areas of the brain affected by depression identified - the lateral orbitofrontal cortex

Depression linked with feelings of not getting rewards, low self-esteem and unhappy memories

Discoveries could open up possible new treatments

Understanding of the physical root of depression has been advanced, thanks to research by the University of Warwick, UK, and Fudan University, China.

The study shows that depression affects the part of the brain which is implicated in non-reward - the lateral orbitofrontal cortex – so that sufferers of the disease feel a sense of loss and disappointment associated with not receiving rewards.

This area of the brain, which becomes active when rewards are not received, is also connected with the part of the brain which is involved in one’s sense of self, thus potentially leading to thoughts of personal loss and low self-esteem.

Depression is also associated with reduced connectivity between the reward brain area in the medial orbitofrontal cortex and memory systems in the brain, which could account for sufferers having a reduced focus on happy memories.

These new discoveries could herald a breakthrough in treating depression, by going to the root cause of the illness, and helping depressed people to stop focussing on negative thoughts.

The study has been carried out by Professor Edmund Rolls from Warwick, Professor Jianfeng Feng from Warwick and from Fudan University in Shanghai, Dr Wei Cheng from Fudan University, and by other centres in China.

In a particularly large study, almost 1,000 people in China had their brains scanned using high precision MRI, which analysed the connections between the medial and lateral orbitofrontal cortex - the different parts of the human brain affected by depression.

“More than one in ten people in their life time suffer from depression, a disease which is so common in modern society and we can even find the remains of Prozac (a depression drug) in the tap water in London.”

“Our finding, with the combination of big data we collected around the world and our novel methods, enables us to locate the roots of depression which should open up new avenues for better therapeutic treatments in the near future for this horrible disease,” Professor Feng continues.

Professor Edmund Rolls looks forward to the new treatments the research could lead to:

"The new findings on how depression is related to different functional connectivities of the orbitofrontal cortex have implications for treatments in the light of a recent non-reward attractor theory of depression. (doi: 10.1016/j.neubiorev.2016.05.007).”

The research, ‘Medial reward and lateral non-reward orbitofrontal cortex circuits change in opposite directions in depression’, is published in Brain (doi: 10.1093/brain/aww255).