Study was performed according to OECD 402 guideline and in compliance with the GLP Regulations.No significant deviations can be observed from the study guidelines, which could have an impact on the performed study. Data on purity are, however, not indicated.

Necropsy of the animals that died on study revealed discolored and/or fluid-filled stomach, distended and/or fluid-filled intestines, discolored kidneys and liver, fluid-filled bladder and necrosis of the skin at the application site.Terminal necropsy revealed discolored lungs in one animal and necrosis of the skin at the application site in all of the animals. No other visible lesions were observed in any animal at terminal necropsy .

Any other information on results incl. tables

The data generated for the acute dermal LD50 in females did not lend itself to the statistical method applied

Applicant's summary and conclusion

Conclusions:

Based on the observations made in the Acute Exposure Dermal Toxicity Study in rabbits, the acute dermal LD50 in males and combined sexes for 6933-6-20 was determined to be 1720.0 (1082.9-2732.0) mg/kg and 1465.4 (1074.6-1998.3) mg/kg, respectively. The data generated for the acute dermal LD50 in females did not lend itself to the statistical method employed.

Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

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