Ziprasidone Hcl is available as Capsules for oral administration and
is most effective when taken with food. It has been approved for treatment
of schizophrenia.

Ziprasidone Hcl is a serotonin dopamine antagonist that works to treat the
positive, negative, and depressive symptoms associated with schizophrenia.
Positive symptoms include visual and auditory hallucinations and delusions.
Negative symptoms, which are harder to treat, include blunted affect, social
withdrawal, and lack of motivation.

Schizophrenia is a chronic illness that requires lifelong treatment.

The efficacy of Capsules ( hydrochloride) as a treatment for
schizophrenia was established in four short-term, four to six week trials
and one long-term 52 week trial. All were placebo-controlled studies in
inpatients, most of whom met DSM III-R criteria for schizophrenia. Each
trial evaluated two or three fixed doses of , ranging from 20 to 100 mg,