Intermittent hypoxia training (IHT) has been demonstrated to be effective in rehabilitation of CAD patients by improving stress resistance and oxygen delivery (Burtcher M. et al.,2004-2011). We suggested a new mode of IHT, where repeated episodes of hypoxia interspersed with breathing by hyperoxia as more effective for exercise tolerance enhancement. In experimental studies adaptation to hypoxia-hyperoxia has been evidenced to evoke more pronounced cardio-protective effects than IHT (Sazontova T.G. et al.,2012).