Does anyone know what the impact might be if I were to discontinue Azathioprine for say, 2 weeks? I have a pesky sinus infection that arrived six months ago - about the same time as starting Aza. I've tried antibiotics and they did nothing. I suspect that the sinus thing is causing me to have tension headaches and other symptoms. So, I want to stop the Aza to give my body a chance to get rid of the infection, and then I'll resume. I'm wary that it took 4 months for the Aza to reach therapeutic levels and don't want to jeopardise all that hard work for the sake of a 2 week holiday.

I'm also on Remicade so of course there are concerns around antibodies as well. How long does it take the body to start producing those?

Aza takes about 3 months to fully leave your system. So whilst you may not feel any negative impact of a brief stop (I've not when I've been lazy getting prescriptions etc in the past) similarly i can't see it helping - as it's still in your system. Can't comment on the remicade impact.Diagnosed: January 2000 Drugs: currently Azathioprine 150mg (Imuran) [14yrs], Humira, B12, Clexane, vitamin D3. Previous drugs: been through the sweet shopBonus probs thanks to Crohns: osteoporosis and blood clotsAge: 49 (but feel over 80 when ill)

The Remission is notorious for upper respiratory infections. Not sure about the AZa, but the Remi is metabolized in about 8 weeks. Antibodies can begin anytime after.Treating the conditions associated with Remi were almost as bad as the disease for my daughter. Just when we were going to quit it...it quit her. Treat the side effects seriously and keep your GI abreast of your overall health. Worried if your stop the UC meds that you will slip off the slope.Daughter, 21 diagnosed 1-08 w/ UC Drug sampling: Asacol,Cortifoam,6mp,Colazal,Rowasa,PPI'S, Flagyl, Pred.,Diet not directly impactful.Remi w/adjustments= remission 4 yrs, re-remission with Tacro 6 mo. Back to Endocort, Uceris,Canasa, hospital(#10), Pancolitis. Retried Remi. Entyvio didn't stop train- Jpouch surgery Step 1, 8/28/14 Step 2, 12/05/14 Takedown 3/23/15 . Living life pain free

Huh, since being on Humira since Feb 2014 I haven't had more than one small cold and it didn't last much longer than before going on it or possibly any longer at all...I was a little concerned about having to miss a shot so once I found out that it's okay to take it so long as you don't have a fever then no issues. I"m glad so far I haven't gotten sicker more often or more easily since being on Humira, I'm actually doing just as well in that regard as I was before Humira for the most part anyway...I've definitely had some flu's over the decades of being sick that took me down pretty hard but I've never had to be hospitalized or anything for having a continuous flaring chronic illness.DX with Crohn's Disease in 1991 shortly after becoming ill. CD was affecting small and large bowel & anus (perianal crohn's skin tags) & rectum for first 2 yrs of becoming sick, CD remained constant in colon (Crohn's colitis) & anus with anal tags, intolerant to oral meds. Currently on Humira (Feb 2014) once a week and B12, Vitamin A and Omega's daily. In remission but trying to combat IBS D/C.