New York Giants at San Francisco 49ers picks and predictions (11/12/18) | Will Eli Manning beat Nick Mullens on Monday Night Football?

When the Giants meet the San Francisco 49ers on Monday night in Santa Clara, Calif., these two teams might have their sights set on the battle for the No. 1 overall pick in the 2019 NFL Draft as the season has not gone as planned for either team.

Giants head coach Pat Shurmur would not commit to Eli Manning starting beyond Monday's contest, while the 49ers look for third-string signal caller Nick Mullens to recreate his magical performance last Thursday night.

Will Manning, wide receiver Odell Beckham Jr., and rookie running back Saquon Barkley be able to spark the offense in the first game of the second half and return back to East Rutherford with their second win of the season?

Here's a roundup of picks from our NJ Advance Media NFL staff as well as predictions from several national reporters:

Matt Lombardo - NJ Advance Media

It's almost incomprehensible how impotent the Giants offense has been this season, given the wealth of offensive weapons at the skill positions around Manning. Entering Monday night, the Giants are averaging 18.8 points per game, which ranks No. 27 in the NFL, and just three of Manning's eight touchdown passes have come prior to the final 2:00 of games, prior to the outcome already being decided. Meanwhile, the Giants rank No. 22 in total offense. Until this team shows an ability to consistently move the football and capitalize on red zone opportunities, it's going to be difficult to expect them to be competitive prior to the final 5:00 of the game, let alone emerge with a victory.

The Pick:

49ers 23, Giants 13

Ryan Dunleavy - NJ Advance Media

49ers vs. Raiders last week was the primetime game featuring two teams with the lowest combined winning percentages in Week 8 or later or a season since 1970. Had the Raiders won instead of the 49ers, this game could have replaced it at the top of the dubious distinction. But the 49ers won and quarterback Nick Mullens became an overnight sensation. Football isn't a 1-on-1 sport, but Eli Manning really needs to outplay Mullens or it could be his final start for the Giants.

The Pick:

Giants 21, 49ers 17

Steve Politi - NJ Advance Media

The 49ers did something detrimental to their overall franchise health last week: They won a football game, and did so in dominant fashion, beating the Raiders 34-3. I have a bad feeling that the Giants are going to do the same thing, because at 1-7 and coming off a bye, Eli Manning has to see this trip as an opportunity to prove that he still deserves to be the starting quarterback.