A Melbourne delivery driver is in hospital with severe fractures to his skull, eye socket and bleeding on the brain after being brutally bashed with a torch in the early hours of the morning by a gap-toothed thug.

The 33-year-old Point Cook man was going about his job, delivering pre-packaged food orders to a home in Wilgah St, St Kilda East, when he was randomly attacked and beaten with a torch about 3.40am on Sunday.

He was left unconscious on the road, as his attacker ran off.

A computer-generated image of the man police want to speak to over the brutal attack. Credit:Victoria Police

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The driver's sister, Alina, made a tearful plea on Thursday for her brother's attacker to hand himself in.

It is expected to take up to six months for her brother's injuries to heal, she said, and his upcoming December wedding will likely be postponed.

Her brother moved to Australia from Pakistan six years ago.

The injured man remains in hospital after undergoing surgery.

"I’m the only relative he has here. He’s the youngest [sibling of five] but we turn to him," she said.

"It's been difficult for me. I wish I could go out and scream and cry loudly.

"He’ll have to postpone his main source of income now. His life has stopped all of a sudden."

Alina asked for her surname not to be published so as not to identify her brother.

Emergency services were called to the scene after a neighbour heard the commotion and rushed to help.

When the neighbour came outside, he found the unconscious man on the road.

Detective Senior Constable Shoshanna Epstein described the attack as a "horrific" assault.

"It's an unprovoked assault on a, by all accounts, gentle and kind man just going about his job," she said.

CCTV of the area shortly before the assault has led police to believe the offender was trying to steal from mailboxes in the area, before he spotted Alina's brother and attacked him.

Senior Constable Epstein said the man was aggressive and verbally abused the victim before assaulting him.

The offender is described as being Caucasian in appearance with brown hair, a pale complexion and missing teeth.

He is believed to be aged between 25 and 35 years old and was wearing black-rimmed glasses.

Police urge anyone who witnessed the assault or who has information to contact Crime Stoppers on 1800 333 000 or crimestoppersvic.com.au.