..PKCgamma knockout mice had significantly higher MAC values than control animals for isoflurane, but not for halothane or desflurane, which implies that protein phosphorylation by PKCgamma can alter sensitivity to isoflurane...

The convulsant and anesthetic properties of cis-trans isomers of 1,2-dichlorohexafluorocyclobutane and 1,2-dichloroethylene

E I EgerDepartment of Anesthesia and Perioperative Care, University of California, San Francisco, California 94143 0464, USAAnesth Analg 93:922-7. 2001

..These isomeric effects may be as useful in defining receptor-anesthetic interactions as those found with optical isomers...

Recovery and kinetic characteristics of desflurane and sevoflurane in volunteers after 8-h exposure, including kinetics of degradation products

E I EgerDepartment of Anesthesia, University of California, San Francisco 94143 0464, USAAnesthesiology 87:517-26. 1997

..The authors determined the kinetic characteristics of desflurane and sevoflurane and those of compound A [CH2F-O-C(=CF2)(CF3)], a nephrotoxic degradation product of sevoflurane...

Desflurane and the nonimmobilizer 1,2-dichlorohexafluorocyclobutane suppress learning by a mechanism independent of the level of unconditioned stimulation

..We conclude that suppression of learning and memory by desflurane and 2N does not result from decreased sensitivity to the unconditioned stimulus (the footshock) and that the potency of 2N is consistent with its lipophilicity...

..They are not, however, the only receptors that contribute to isoflurane-induced immobility (i.e., that determine the MAC of isoflurane)...

Cardiovascular effects of I653 in swine

R B WeiskopfDepartment of Anesthesia, University of California, San FranciscoAnesthesiology 69:303-9. 1988

..2 MAC, 120 +/- 4 at 1.6 MAC). Systemic vascular resistance increased slightly at 1.6 MAC compared to the values at 0.8 and 1.2 MAC, but was always less than in the conscious condition.(ABSTRACT TRUNCATED AT 250 WORDS)..

..The Schaffer collateral-CA1 synapse may serve as a useful model for the production of immobility by volatile anesthetics, but is flawed as a model for the capacity of volatile anesthetics to interfere with memory and learning...

The effect of rigidity, shape, unsaturation, and length on the anesthetic potency of hydrocarbons

E I EgerDepartment of Anesthesia and Perioperative Care, University of California, San Francisco, California 94143 0464, USAAnesth Analg 92:1477-82. 2001

..0055 atm) and that 3-hexyne was more potent (MAC 0.0146 +/- 0.0014 atm) than n-hexane (MAC 0.0467 +/- 0.0055 atm). We conclude that the site of anesthetic action can accommodate straight rigid structures of up to six carbons in length...

Changing from isoflurane to desflurane toward the end of anesthesia does not accelerate recovery in humans

M A NeumannDepartment of Anesthesia, University of California, San Francisco, 94143, USAAnesthesiology 88:914-21. 1998

..The authors tried to determine whether substituting desflurane for isoflurane in the last 30 min of a 120-min anesthetic would accelerate recovery...