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Features and Benefits

Testosterone—It’s What Makes a Man a Man™

Testosterone is the male hormone you can’t ignore if you
want to stay the man you know you can be. Maintaining healthy T-levels already within the normal range is an
important goal for many men who want to promote healthy aging.*

The Purity Products R & D team has formulated Zestosterone™,
a unique blend of researched nutraceutical ingredients that can help maintain
healthy testosterone levels.*

Support Testosterone

Finally, there’s a science-based way to be proactive about
testosterone! Purity’s "Zestosterone™ Proprietary Blend contains calcium
fructoborate, a unique and patented form of the trace mineral boron found in fruit and vegetables. Boron is believed to play an important role in
the metabolism of vitamin D and steroid hormones.*

Among its many benefits, Vitamin D is also helpful for testosterone support.*
Zestosterone™ provides the exact amount used in a recent study showing that 3332
IU of vitamin D given as a daily supplement raised testosterone levels in men
deficient in Vitamin D. (Pilz S, et al. Effect of vitamin D supplementation on
testosterone levels in men. Horm Metab Res. Dec 10, 2010.)

Testosterone is a pivotal hormone positively correlated to a man’s energy level,
strength, fitness, mood, brain function, vigor, virility and libido. To further
support healthy testosterone levels, Zestosterone™ also features three
ingredients specially selected for testosterone and prostate health supporting
benefits:

Don't Forget About Prostate Support -- with Beta Sitosterol

In conjunction with maintaining healthy testosterone levels, keeping the
prostate in good shape is vital for overall male health as we age.
Beta-Sitosterol, one among a family of substances found in plants called
"phytosterols," is an effective solution for supporting prostate and
urinary function in men.* In a multi center, placebo-controlled trial reported
in the British Journal of Urology, 177 men took beta sitosterol daily for 6
months. Results confirmed the ability of beta sitosterol to support healthy
prostate and urinary function.* Zestosterone™ delivers 130 mg of beta sitosterol
per serving, the precise amount given in this landmark study.

OptiZinc® and Grape Seed Extract

Zestosterone also provides the full daily allowance of a premium grade
OptiZinc® (US patents 4,764,633 and 5,278,329), a crucial "male mineral" that
supports fertility, libido and helps keep the prostate healthy.* Zinc is needed
for the function of nearly 300 enzymes in the body, and it is involved in many
areas of health including immunity and reproductive health.* To round out the
formula, Leucoselect®, a top-quality grape seed extract, is added for the
circulatory support that’s important to healthy reproductive function in
men.*

10 Strategies for OptimumTestosterone

If you’re a man, keeping your testosterone level up is probably one of your
health goals. After all, testosterone--primary male hormone—is often said to be
“what makes a man a man.” Short of using testosterone replacement therapy, which
of course should only be attempted under the guidance of a physician, are there
things men can do to maintain healthy testosterone levels? While there’s no
magic bullet, a number of health strategies—nutritional and lifestyle
approaches—show promise. Here are 10 to think about.

Optimum health on all levels requires a nutritious diet with the right
balance of protein, fat and carbohydrates. To maintain a healthy testosterone
level, eating the right fats is especially important. Studies have found that
low fat diets can decrease testosterone, so don’t skimp on the fat, just make
sure you include polyunsaturated fats—both omega-3s and omega 6s--and
monounsaturated fat. Saturated fat, such as found in meat is OK; in fact we
need saturated fat to produce testosterone. In fact, there’s evidence that
eating a vegetarian diet may make it harder to keep testosterone up. (Volek JS,
et al. Testosterone and cortisol in relationship to dietary nutrients and
resistance exercise. J Appl Physiol 1997; 82:49-54.)

This is high on the list. Stress is a part of life and there’s no
need to try and avoid stress altogether, even if that were possible. But
there’s no debate about the negative effects of chronically high stress—psychological
stress in particular-- on health, although we usually think about the heart and
cardiovascular systems as most vulnerable to its deleterious effects. But
excessive, uncontrolled stress is, in a word, bad for testosterone. This has
been studied, the physical and psychological strain of intense military
training, for example, has been shown to lower testosterone levels in young
men. (Gomez-Merino D, et al. Immune and hormonal changes following intense
military training. Mil Med 168(12):1034-8, 2003) How does stress affect
testosterone? There’s a direct biochemical connection through cortisol, a
hormone we produce every day. Cortisol acts to raise blood glucose levels, and
this is a normal part of the fight-or-flight mechanism that ensures we have the
energy to flee a life-threatening situation. Chronic stress can lead to
chronically elevated cortisol levels, which in turn can suppress production of
testosterone in the testes. So, to keep testosterone up, keep stress under
control. (Hardy MP, Ganjam VK. Stress, 11ß-HSD, and Leydig cell function. J
Androl 1997;18(5):475-9.)

Being overweight is another health thief that can also rob you of
testosterone. An elevated Body Mass Index (BMI; a measure of body fat) not only
lowers testosterone, there’s evidence it increases estrogen. Hammoud A, et al.
Effect of Roux-en-Y gastric bypass surgery on the sex steroids and quality of
life in obese men. J Clin Endocrinol Metab 2009;94(4):1329-32.) To avoid this
anti-testosterone double whammy, by all means keep your BMI in the ideal
range.

Moderate exercise, especially resistance calisthenics such as squats and
bench presses that use large muscle groups, are known to produce a temporary
testosterone boost. But don’t overdo it. A 2008 study found that excessive
endurance training decreases both free and total testosterone. (Hackney AC.
Effects of endurance exercise on the reproductive system of men: the
exercise-hypogonadal male condition. J Endocrinolo Invest 2008; 31(10):932-8.)
Moderate regular workouts to keep your cardiovascular system healthy and body
weight down, along with a sensible routine of resistance exercises, is the best
approach.

On the subject of exercise, a simple exercise that you can do while standing
in line at the bank, one that requires no equipment whatsoever, is the Kegel.
Commonly recommended for women, expectant mothers in particular, "Kegels"
strengthen the muscles of the pelvic floor. You’ve actually been doing Kegels
since the first time you had to "hold it in" as a kid. To perform a Kegel,
simply contract the muscles as if you were caught in traffic with the need to
urinate. (Variations of Kegel exercises are done in Oriental exercise systems
such as "Qigong" to strengthen the "Qi" or life energy.) The benefits are many;
increased blood flow to the lower pelvic muscles is good for the prostate and
has been shown to improve erectile function.( Dorey G, et al. Pelvic floor
exercises for erectile dysfunction. BJU 2005;96(4):595-7.)

It goes without saying that getting enough sleep is prerequisite to health.
Testosterone production increases during sleep, so we can’t shortchange on
adequate sleep and expect to have optimal testosterone. In a study reported in
the Journal of the American Medical Association, sleep deprivation caused steep
declines in testosterone levels. And this was in young men; middle-age and
older men might have fared worse. (Research Letter. Effect of 1 Week of Sleep
Restriction on Testosterone Levels in Young Healthy Men. JAMA. 2011;305(21):2173-2174.)
Along with sufficient restful sleep, relaxing, stress-fighting techniques such
as meditation, yoga and Tai Chi, should help you maintain testosterone in a
healthy range. Try it out.

Vitamin C: Vitamin Chas been shown to blunt increase cortisol in marathon
runners and as we’ve seen, anything we can do to keep cortisol from elevating is
helpful for testosterone support. (Peters EM, et al. Vitamin C supplementation
attenuates the increases in circulating cortisol, adrenaline and anti-inflammatory
polypeptides following ultramarathon running. Int J Sports Med 2001;22(7):537-43.)
Animal studies showed a positive effect of vitamin C on testosterone and sperm
quality. (Sönmez M, et al. the effect of ascorbic acid supplementation on sperm
quality, lipid peroxidation and testosterone levels of male Wistar rats.
Theriogenology 2005; 63(7):2063-72.) Vitamin C is one of the basic dietary
antioxidants, and there is evidence from animal studies that it may protect the
testes from the damaging effects of toxins, while preserving testosterone at the
same time. (Das UB, et al. Protective effect of ascorbic acid on cyclophosphamide-
induced testicular gametogenic and androgenic disorders in male rats. Asian J
Androl 2002;4(3):201-7.

Vitamin D: This versatile vitamin (actually it’s a hormone) does many thing for
us, and a recent study tells us it may raise testosterone levels, especially
vitamin D –deficient men who are also overweight. Given the prevalence of
obesity—coupled with growing agreement among scientists that most of us get far
too little—we should not neglect this all-important vitamin if we want to keep
testosterone up to par. (Pilz S, et al. effect of vitamin D supplementation on
testosterone levels in men. Horm Metab Res 2011;43(3):223-5.)

Zinc: Low testosterone is a direct effect of zinc deficiency. Make sure you
get enough of the "male mineral." (Prasad AS, et al. Zinc status and
testosterone levels of healthy adults. Nutrition 1996; 12(5);344-80.) Zinc is
an absolute must for health of your reproductive system.

Selenium: Selenium is another essential mineral that plays a key role in the
male reproductive system. Sperm motility as well as the biosynthesis of
testosterone requires selenium. (Margaret P, Rayman D. The importance of
selenium to human health. Lancet 2000; 356(9225):233-41.)

Boron: Boron is a hormonal support mineral; studies have shown it raises
testosterone in women, and for men, it increases free testosterone, the portion
of total testosterone. This is important because free testosterone is the form
of the hormone in the bloodstream that’s available for use by the body. The rest
is bound to a carrier protein called Sex Hormone Binding Globulin (SHBG). As we
age, SHBG tends to rise.Boron supplementation helps to unbind testosterone from
SHBG, giving us a little more "free T." (Does this sound like potential T-shirt
material (no pun intended)? Maybe Free the Bound T!) (Naghii MR, et al.
Comparative effects of daily and weekly boron supplementation on plasma steroid
hormones and proinflammatory cytokines. J Trace Elem Med Biol 2011;25(1):54-8.)

Caution: The dietary supplement marketplace has seen a floodtide in recent
years of "herbal Viagra" products that claim to turn you into the Italian
stallion and add 4-6 inches to your penis size overnight. Most contain a
repetitive mix of herbs that do neither thing. (The latter claimed effect is
physiologically impossible; as a urologist will tell you, a man has what he is
genetically endowed with and that’s about it, sorry. The best you can do is to
reach your maximum erectile length through blood flow.) Use with extreme
caution, the only reason these products can accurately be called "herbal
Viagra" is that they are often spiked with Viagra. Unfortunately, such products
are illegal drugs and potentially dangerous.

That said, are there herbs and other nutraceutical ingredients that can help
keep testosterone, and your anatomy, up? The science in this arena is far from
mature, but a few hold promise:

Fenugreek: This common herb may turn out to be a testosterone booster. In a 2007
study, thirty men took 500 mg of fengreek or a placebo daily while also
participating in a resistance training program. Those in the fenugreek group had
increases in both total and free testosterone, along with increased lean body
mass. (Wilborn C, et al. Effects of a purported aromatase and 5a-reductase
inhibitor on hormone profiles in college-age men. Int J Sport Nutr Exerc Metab
2010;20(6):457-65.)

Ginseng: This long-popular herb is well established as a tonic for the whole
body, including the reproductive system. It may possibly boost testosterone,
especially in men with waning fertility. (Salvati G, et al. Effects of Panax
ginseng C.A. Meyer saponins on male fertility. Panimerva Med 1996;38(4):249-54.)

Saw Palmetto: The Saw palmetto berry is rich in fatty acids and other fat-like
compounds (sterols) which are known to benefit the prostate. While it has no
direct effect on testosterone in the bloodstream, Saw palmetto helps prevent
testosterone in the prostate gland from turning into DHT, which in turn can
promote prostate enlargement. It does this by inhibiting 5-alpha reductase, an
enzyme that converts T to DHT. (Raynaud JP, et al. Inhibition of type 1 and type
2 5alpha-reductase activity by free fatty acids, active ingredients of Permixon.
J Steroid Biochem Mol Biol 2002;82(2-3):233-9.)

L-Arginine: This amino acid is effective at supporting healthy erectile
function. It works by stimulating release of nitric oxide which relaxes blood
vessels in the penis, allowing for unimpeded blood flow and a complete erection.
L-arginine is especially effective when combined with other circulation
enhancers like pycnogenol. While L-arginine has no known direct effect on
testosterone, men taking the combination for erectile support in controlled
clinical trials show measureable increases in T, likely due to the fact that
their sexual activity increases. (Stanislavov R, et al. Improvement of erectile
function with Prelox: a randomized, double-blind, placebo-controlled, crossover trial, Int J Impot Res, 2008;20:173-80.)

L-Citrulline: L-citrulline is an amino acid that is converted to L-arginine
in the bloodstream. L-citrulline has been found to improve erection hardness.
(Cormio L, et al. Oral L-citrulline supplementation improves erection hardness
in men with mild erectile dysfunction. Urology. 2011 Jan;77(1):119-22.)

Plenty has been written on this subject, but one thing is clear. Sexual
activity, and stimulation, increases testosterone. T is of course good for sex
and the reverse is true. The two go hand in hand like, well, love and marriage.
Enough said.

Quality Assurance

To meet established specifications for dietary supplements, our manufacturer adheres to the highest quality control standards, including:

• NSF International GMP Registration
• Health Canada GMP Certified
• Written Standard Operating Procedures (SOPs) to comply with current Good Manufacturing Practice (cGMP) for dietary supplements, in accordance with 21 CFR Part 111
• Finished products that meet or exceed United States Pharmacopeia (USP37/NF32) specifications
• Certificates of Analysis available
• VCP (Vendor Certification Program) to ensure raw material quality
• Compliance with the Public Health Security and Bioterrorism Preparedness and Response Act of 2002