Genetics

Improve the Psychological Health of Mothers of Children With Fragile X Syndrome with Mindfulness

By John M. de Castro, Ph.D.

“the key to reducing caregiver burnout and compassion fatigue lies in what can be construed to some as the seemingly counter intuitive wisdom of mindfulness. Being mindful and engaging in radical self-care is proving to be one of the most effective ways to take care of your loved one while fortifying yourself.” – Audrey Meinertzhagen

Fragile X Syndrome is an incurable genetic disorder that involves the FMR1 gene on the X Chromosome. This gene is involved in promotion communications between neurons in the nervous system. This disorder affects about 200,000 children a year in the US and is characterized by trouble learning skills like sitting, crawling, or walking, problems with language and speech, hand-flapping and not making eye contact, temper tantrums, poor impulse control, anxiety, extreme sensitivity to light or sound, and hyperactivity and trouble paying attention. Some children with fragile X also have changes to their face and body that can include a large head, long, narrow face, large ears, a large forehead and chin, loose joints, and flat feet.

Needless to say, raising these children can be a challenge and place considerable stress on the caregivers. Caregiving exacts a tremendous toll on caregivers’ health and well-being. Caregiving has been associated with increased levels of depression and anxiety as well as higher use of psychoactive medications, poorer self-reported physical health, compromised immune function, and increased mortality. The challenges of caring for a child with Fragile X Syndrome requires that the individual be able to deal with stress, to regulate their own emotions, and to be sensitive and attentive. These skills are exactly those that are developed in mindfulness training. It improves the psychological and physiological responses to stress. It improves emotion regulation. And it improves the ability to maintain attention and focus in the face of high levels of distraction. So, it is not surprising that mindfulness improves caregiving and assists the caregiver in coping with the stress.

In today’s Research News article “Mindfulness and Acceptance as Potential Protective Factors for Mothers of Children With Fragile X Syndrome.” (See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232517/ ), Wheeler and colleagues administered an online survey to mothers of children with Fragile X Syndrome. They measured the severity of the child’s disability, perceived stress, mindfulness, mindful parenting, anxiety, depression, physical health, and psychological acceptance. They then performed a regression analysis to explore the relationships between these variables.

They found that overall the mothers were high in perceived stress and anxiety. The child’s symptoms took their toll as the greater the severity of the child’s disability the higher the levels of stress, anxiety, depression, and physical symptoms in the mothers. They also found that mindfulness and acceptance appeared to buffer these effects with high levels of mindfulness and acceptance associated with low levels of stress, anxiety, depression, and physical symptoms and high levels of mindful parenting associated with low levels of anxiety, depression, and physical symptoms. Importantly, acceptance attenuated the effect of the child’s disability the lower the levels of physical symptoms. Being mindful and accepting of the child’s condition and behavior were very highly associated with reduced maternal distress.

These results are interesting but they are correlational and causation cannot be determined. But they suggest that mindfulness, mindful parenting, and acceptance are important for dealing with the deleterious effects of caring for a child with Fragile X Syndrome. Previous research has shown that mindfulness can produce improvements in the caregiver’s psychological state. So, it is likely that there is a causal connection between mindfulness and the psychological state of caregivers for children with Fragile X Syndrome.

These results suggest that training in mindfulness, mindful parenting, and acceptance may be greatly beneficial for mothers caring for children with Fragile X Syndrome, reducing their distress and potentially improving their caregiving for the child. This is a difficult situation for the mothers and such help could be greatly beneficial.

So, improve the psychological health of mothers of children with Fragile X Syndrome with mindfulness.

“mindfulness practices could be helpful for these caregivers because they encourage a nonjudgmental interpretation of their child’s situation, and increased acceptance of their reality. Mindfulness practices also help people observe their thoughts and behaviors with less reactivity and judgment, which could enable caregivers to better respond to the emotional and physical difficulties they encounter.” – Emily Nauman

Women with an FMR1 premutation may be at increased genetic risk for stress vulnerability. This increased vulnerability, when combined with stressful parenting that can result from raising children with fragile X syndrome (FXS), may result in negative physical and emotional outcomes. Mindfulness and acceptance have been found to be protective factors for parents of children with similar behavioral challenges, but these traits have not previously been explored among mothers with a child with FXS. This study explored the associations of child disability severity with maternal stress, anxiety, depression, and physical health symptoms in 155 biological mothers of children with FXS. Women completed an online survey using standardized measures of stress, mindfulness, and acceptance. General mindfulness, mindfulness in the parenting role, and general acceptance were explored as potential protective factors between the child disability severity and maternal outcomes. Trait mindfulness and acceptance were significant predictors of lower stress, anxiety, depression, and daily health symptoms, while mindful parenting was associated with lower stress, anxiety, and depression. Acceptance was found to attenuate the effects of child severity on maternal stress and depression. These findings suggest that interventions focused on improving mindfulness and acceptance may promote health and well-being for mothers of children with FXS and have important health implications for all individuals with an FMR1 premutation.

“Mindfulness has been shown to be an effective stress reduction practices in general, but there may be other ways it works for people with PTSD as well. Recent research suggests that mindfulness may help to mitigate the relationship between maladaptive thinking and posttraumatic distress.” – Matthew Tull

Experiencing trauma is quite common. It has been estimated that 60% of men and 50% of women will experience a significant traumatic event during their lifetime. But only a fraction will develop Post-Traumatic Stress Disorder (PTSD). But this still results in a frightening number of people with 7%-8% of the population developing PTSD at some point in their life.

PTSD involves a number of troubling symptoms including reliving the event with the same fear and horror in nightmares or with a flashback. PTSD sufferers avoid situations that remind them of the event this may include crowds, driving, movies, etc. and may avoid seeking help because it keeps them from having to think or talk about the event. They often experience negative changes in beliefs and feelings including difficulty experiencing positive or loving feelings toward other people, avoiding relationships, memory difficulties, or see the world as dangerous and no one can be trusted. Sufferers may feel hyperarousal, feeling keyed up and jittery, or always alert and on the lookout for danger. They may experience sudden anger or irritability, may have a hard time sleeping or concentrating, may be startled by a loud noise or surprise.

In today’s Research News article “Methylation of FKBP5 and SLC6A4 in Relation to Treatment Response to Mindfulness Based Stress Reduction for Posttraumatic Stress Disorder.” (See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6153325/ ), Bishop and colleagues examine the activation of genes associated with stress and depression in patients with PTSD who responded and did not respond to treatment with Mindfulness Based Stress Reduction (MBSR), They examined patients from a previous study of the effectiveness of MBSR for the treatment of PTSD who showed a significant reduction in PTSD symptoms and those that did not. The MBSR treatment consisted of body scan, meditation, and yoga practices and group discussion and occurred in 9 weekly, 2.5 hour sessions. with homework. Blood samples were drawn before and after treatment. They measured the degree of methylation of genes in the he promoter region of SLC6A4 previously associated with depression risk and symptoms and genes in the FKBP5 Intron 7 region identified as a functional regulator of glucocorticoid signaling.

They found that after Mindfulness Based Stress Reduction (MBSR) treatment there was a significant reduction in methylation of genes in the FKBP5 Intron 7 region in responders but an increase in non-responders. These genes are associated with stress related responding. Methylation tends to suppress gene expression, So, decreased methylation indicates an increased level of activity in stress related hormonal pathways.

These findings are interesting but not surprising as MBSR was developed specifically to improve stress responses. It is interesting that only patients who responded to treatment had this change to the genes underlying stress responding. So, it appears that MBSR is effective for PTSD symptoms but only if it changes stress related gene expression. It will be interesting to examine in the future the factors that result in non-responders being resistant to treatment with MBSR.

“Many people cope with trauma by distancing themselves from the sensations in their bodies and minds (the most extreme example of this is dissociation). Therefore, bringing one’s attention deliberately back to the body can unzip trauma symptoms they may not be prepared to address. However, mindfulness meditation canbe helpful to those with PTSD and a history of trauma when practiced under the guidance of a mental healthcare provider and modified to be better suited for trauma survivors.” – Julia Ozog

Mindfulness Based Stress Reduction (MBSR) is an effective non-pharmacologic treatment for veterans with PTSD. Extensive work has identified epigenetic factors related to PTSD disease risk and pathophysiology, but how these factors influence treatment response is unclear. Serotonin signaling and hypothalamic-pituitary-adrenal (HPA) axis functioning may be perturbed in PTSD and are molecular pathways targeted by PTSD treatments. To identify potential biomarkers for treatment response, we utilized genomic DNA isolated from peripheral blood samples from veterans with PTSD who were responders (n = 11) or non-responders (n = 11) to MBSR as part of a clinical trial. We assessed methylation levels at CpG sites in regions of the serotonin transporter (SLC6A4) previously associated with expression and depression outcomes, as well as the Intron 7 region of the FK506 binding protein 5 (FKBP5) containing known glucocorticoid response elements suggested to regulate this gene. Selected subjects were matched across MBSR responder status by baseline symptoms, age, sex, current smoking status, and current antidepressant use. Percent methylation was compared between responders and non-responders at baseline (pre-MBSR treatment). Additionally, percent change in methylation from baseline to post-treatment was compared between responders and non-responders. There was a significant time x responder group interaction for methylation in FKBP5 intron 7 bin 2 [F(1, 19) = 7.492, p = 0.013] whereby responders had a decrease in methylation and non-responders had an increase in methylation from before to after treatment in this region. Analyses of the three CpG sites within bin 2 revealed a significant time x responder group interaction for CpG_35558513 [F(1, 19) = 5.551, p = 0.029] which resides in a known glucocorticoid response element (GRE). Decreases in FKBP5 methylation after treatment in responders as compared to increases in non-responders suggest that effective meditation intervention may be associated with stress-related pathways at the molecular level. These preliminary findings suggest that DNA methylation signatures within FKBP5 are potential indicators of response to meditation treatment in PTSD and require validation in larger cohorts.

“What we do know is that long-term engagement in mindfulness meditation may enhance cognitive performance in older adults, and that with persistent practice, these benefits may be sustained. That’s great news for the millions of aging adults working to combat the negative effects of aging on the brain.” – B. Grace Bullock

Human life is one of constant change. We revel in our increases in physical and mental capacities during development but regret their decreases during aging. The aging process, starting in the 20s involves a systematic progressive decline in every system in the body, the brain included. There is interest in finding ways to slow the aging process to improve longevity and health and mindfulness training has been found to do just that.

DNA methylation is an epigenetic mechanism used by cells to control gene expression. Epigenetic effects on the DNA arise from the environment and not the genes themselves. DNA methylation can fix genes in the “off” position, preventing them from carrying out their normal function. Indeed, the amount of methylation of DNA is associated with disease and aging. The greater the amount of methylation in the DNA the more disease. It can be thought of as a cellular marker of aging. It is sometimes considered as an epigenetic clock, the greater the age, the more methylation. It is possible that meditation practice slows the aging process by decreasing methylation in the DNA.

In today’s Research News article “Epigenetic clock analysis in long-term meditators.” (See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5863232/ ), Chaix and colleagues obtained blood samples from meditation naïve individuals and long-term (> 3 years) meditators. The samples were assayed for methylation in the DNA and this was used to calculate the intrinsic epigenetic age of the individual (the age predicted by the degree of DNA methylation).

They found, as expected, that the greater the amount of methylation of the DNA the greater the actual calendar age of the participant for both groups. In the meditation naïve participants those over 52 years of age had significantly higher intrinsic epigenetic ages than those under 52. This is as expected. On the other hand, the long-term meditators over 52 years of age had equivalent intrinsic epigenetic ages to those under 52. The longer the meditators had been practicing the greater the reduction in their intrinsic epigenetic age. It was reduced by 0.24 years for each year of meditation practice.

These results suggest a possible mechanism by which meditation practice may slow the aging process. They suggest that meditation practice reduces the methylation in the DNA and perhaps, thereby, helps maintain the DNA’s functional integrity into higher ages. Stress is known to increase DNA methylation. So, it is possible that mindfulness practices reduce methylation in the DNA by reducing the physiological and psychological effects of stress. Regardless, the results suggest that meditation practice slows the changes in the individual’s genetic material that’s associated with aging.

So, slow aging with meditation.

“According to the National Institutes of Health, more than 20 million Americans practice some form of meditation to achieve greater peace of mind and enhanced sense of well-being. Now studies of the neurological differences between meditators and non-meditators, and studies of immune cell aging via telomere length in meditators and non-meditators, show that meditation can also affect the way we age.” – Seth Segall

In this paper, we examined whether meditation practice influences the epigenetic clock, a strong and reproducible biomarker of biological aging, which is accelerated by cumulative lifetime stress and with age-related chronic diseases. Using the Illumina 450 K array platform, we analyzed the DNA methylome from blood cells of long-term meditators and meditation-naïve controls to estimate their Intrinsic Epigenetic Age Acceleration (IEAA), using Horvath’s calculator. IEAA was similar in both groups. However, controls showed a different IEAA trajectory with aging than meditators: older controls (age ≥ 52) had significantly higher IEAAs compared with younger controls (age < 52), while meditators were protected from this epigenetic aging effect. Notably, in the meditation group, we found a significant negative correlation between IEAA and the number of years of regular meditation practice. From our results, we hypothesize that the cumulative effects of a regular meditation practice may, in the long-term, help to slow the epigenetic clock and could represent a useful preventive strategy for age-related chronic diseases. Longitudinal randomized controlled trials in larger cohorts are warranted to confirm and further characterize these findings.

“Yoga is fantastic for decreasing stress levels, and research has also shown that those who practice yoga regularly have higher levels of leptin and adiponectin in their bodies. Both of these natural chemicals work to alleviate inflammation in the body.” – Julie Montagu

The immune system is designed to protect the body from threats like stress, infection, injury, and toxic chemicals. One of its tools is the Inflammatory response. This response works quite well for short-term infections and injuries. But when inflammation is protracted and becomes chronic, it can itself become a threat to health. It can produce autoimmune diseases such as colitis, Chron’s disease, arthritis, heart disease, increased cancer risk, lung disease, sleep disruption, gum disease, decreased bone health, psoriasis, and depression. Needless to say, chronic inflammation can create major health problems. Indeed, the presence of chronic inflammation is associated with reduced longevity. So, it is important for health to control the inflammatory response, allowing it to do its job in fighting off infection but reducing its activity when no real external threat is apparent.

Of course, it is far better to prevent chronic inflammation in the first place than to treat it later. Mind-body techniques such as yoga, Tai Chi and meditation have been shown to adaptively reduce the inflammatory response. In today’s Research News article “Preliminary indications of the effect of a brief yoga intervention on markers of inflammation and DNA methylation in chronically stressed women.” (See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5290356/ ), Harkess and colleagues recruited women who were psychologically distressed and randomly assigned them to either a wait-list or to receive 8 weeks of twice a week for 1-hour yoga practice. Blood samples were obtained from the participants and measures of psychological distress, perceived stress, and positive and negative emotions, before and after the practice and 1 month later. Blood was assayed for concentrations of cytokines (IL-6, TNF), DNA methylation for immune candidates IL-6, CRP, and TNF.

They found that there were trends for improvements in all of the inflammation markers, but most were not significant. But, there was a significant improvement in the marker of DNA methylation in the region of Tumor Necrosis Factor, TNF. DNA methylation have been associated with poor physical health, and high levels of inflammation. So, the reduction in DNA methylation in the TNF region suggests a reduction in chronic inflammation. This may suggest that yoga practice might improve general health by reducing chronic inflammation.

It is reasonable to conclude that although there were many suggestive results, this pilot trial did not have sufficient statistical power to detect significant differences for most markers. Also, more extensive yoga practice beyond the 16 sessions in this trial, might produce more robust effects. In addition, the pilot trial lacked an active control condition. So, a number of sources of bias could be responsible for the results. The results, however, are sufficiently interesting and suggestive that they support conducting a larger randomized controlled clinical trial with an active control, perhaps aerobic exercise on the effectiveness of yoga practice on genetic markers of inflammation.

Yoga is associated with reduced stress and increased well-being, although the molecular basis for these benefits is not clear. Mounting evidence implicates the immune response, with current studies focused on protein immune markers (such as cytokines) in clinical populations. To explore the molecular impact, this pilot study uses a subsample (n=28) from a randomised waitlist control trial investigating the impact of an 8-week yoga intervention in a community population of women reporting psychological distress (N=116). We measured interleukin-6 (IL-6), tumour necrosis factor (TNF) and C-reactive protein (CRP) protein levels, and the DNA methylation of these genes and the global indicator, LINE-1. Correlations between these and psychological variables were explored, identifying moderate correlations with CRP protein levels, and methylation of IL-6, CRP and LINE-1. Many cytokine samples were below detection, however a Mann–Whitney U demonstrated a trend of moderate between-group effect for elevated IL-6 in the yoga group. Methylation analyses applied cross-sectional and non-controlled longitudinal analyses. Waist-to-height ratio and age were covaried. We demonstrated reduced methylation of the TNF region in the yoga group relative to the waitlist control group. No other genes demonstrated a significant difference. Longitudinal analysis further supported these results. This study is one of the first to explore yoga and immunological markers in a non-clinical population, and is the first study to explore DNA methylation. These findings indicate that further research into molecular impact of yoga on markers of immune function is warranted, with larger studies required.

“long-term engagement in mindfulness meditation may enhance cognitive performance in older adults, and that with persistent practice, these benefits may be sustained. That’s great news for the millions of aging adults working to combat the negative effects of aging on the brain.” B. Grace Bullock

Human life is one of constant change. We revel in our increases in physical and mental capacities during development, but regret their decreases during aging. The aging process involves a systematic progressive decline in every system in the body, the brain included. Starting in the 20s there is a progressive decrease in the volume of the brain as we age.

In today’s Research News article “Promising Links between Meditation and Reduced (Brain) Aging: An Attempt to Bridge Some Gaps between the Alleged Fountain of Youth and the Youth of the Field.” See summary below or view the full text of the study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5447722/, Kurth and colleagues review and summarize the published research literature on the neuroprotective effects of meditation in the elderly. They discuss the ideas that the aging based deterioration of the brain is due to a number of processes, including changes in the DNA telomeres, inflammation, stress, and neuroplasticity and that meditation appears to effect all of these processes.

There has accumulated evidence that meditation protects against age related decline at the molecular genetic level. As we age the length of a DNA structures called the telomeres progressively shorten. It is thought that the shorter the telomeres get the more difficult it becomes for cells to replicate properly and thus leads to decline. Mindfulness training in general and meditation specifically, has been shown to reduce the shortening of the telomeres with aging. Kurth and colleagues speculate that this is one mechanism by which meditation protects the brain from age related decline.

As we age the natural inflammatory response that normally occurs to protect against infection begins to increase in general and lose its specificity to fighting particular diseases, pathogens, and injuries. It becomes more widespread damaging normal tissues. Mindfulness training in general and meditation specifically has been shown to reduce inflammatory responses. It seems reasonable that this is another mechanism by which meditation protects the body from age related decline.

Stress is present throughout life. But if it is too intense or prolonged the biological responses to stress begin to damage the body. These stress induced changes are similar to age related deterioration. Stress effects may accumulate over time. Hence, the older we get the greater the total stress induced damage. Mindfulness training in general and meditation specifically has been shown to improve emotion regulation and to reduce the physiological and psychological responses to stress. This is hypothesized to be another mechanism by which meditation protects the brain from deterioration with aging.

Hence there has accumulated evidence that meditation reduces the deterioration of the brain with aging. It appears to do so by altering a number of different mechanisms including changes in the DNA telomeres, inflammation, stress, and neuroplasticity. This protection of the brain may be responsible to the ability of meditation to reduce the decline in mental abilities that occur with aging. This would tend to make aging a more benign process.

So, protect the aging brain with meditation.

We expected rather small and distinct effects located in some of the regions that had previously been associated with meditating. Instead, what we actually observed was a widespread effect of meditation that encompassed regions throughout the entire brain.” – Florian Kurth

Kurth, F., Cherbuin, N., & Luders, E. (2017). Promising Links between Meditation and Reduced (Brain) Aging: An Attempt to Bridge Some Gaps between the Alleged Fountain of Youth and the Youth of the Field. Frontiers in Psychology, 8, 860. http://doi.org/10.3389/fpsyg.2017.00860

Abstract

Over the last decade, an increasing number of studies has reported a positive impact of meditation on cerebral aging. However, the underlying mechanisms for these seemingly brain-protecting effects are not well-understood. This may be due to the fact, at least partly, that systematic empirical meditation research has emerged only recently as a field of scientific scrutiny. Thus, on the one hand, critical questions remain largely unanswered; and on the other hand, outcomes of existing research require better integration to build a more comprehensive and holistic picture. In this article, we first review theories and mechanisms pertaining to normal (brain) aging, specifically focusing on telomeres, inflammation, stress regulation, and macroscopic brain anatomy. Then, we summarize existing research integrating the developing evidence suggesting that meditation exerts positive effects on (brain) aging, while carefully discussing possible mechanisms through which these effects may be mediated.

“Researchers globally are continuing to explore how telomerase activity can be a measure of the effects of psychological stress on physical health. As they study the different types of meditation in more detail and uncover more of the benefits for cell aging, we will gain a deeper understanding of the new-found link between mind and body health. In the meantime, it seems that any type of meditation can do some good for your longevity.” – Courtney Danyel

Meditation practice has been shown to improve health and longevity. One way it appears to act is by altering the genes which govern cellular processes in our bodies. One of the most fundamental of these processes is cell replication. Our bodies are constantly turning over cells. Dying cells or damaged are replaced by new cells. The cells turn over at different rates but most cells in the body are lost and replaced between every few days to every few months. Needless to say were constantly renewing ourselves.

As we age the tail of the DNA molecule called the telomere shortens. When it gets very short cells have a more and more difficult time reproducing and become more likely to produce defective cells. On a cellular basis this is what produces aging. There is an enzyme in the body called telomerase that helps to prevent shortening of the telomere. So, processes that increase telomerase activity tend to slow the aging process. Contemplative practice has been shown to increase telomerase activity thus helping to prevent cellular aging. It is thought that this protection of telomeres could protect the body’s cells from aging and deterioration and be the basis for the increased longevity in contemplative practitioners. So, it is important to further investigate the effects of contemplative practices on telomeres and telomerase.

In today’s Research News article “Meditation and vacation effects have an impact on disease-associated molecular phenotypes.” See:

or see summary below, Epel and colleagues studied the impact of a 5-day intensive meditation retreat on the genes associated with health and longevity. They compared two groups of people participating in a meditation retreat, novices and experienced meditators to a novel vacation control group which spent a comparable amount of time in a spa in the same location at the same time simply relaxing. The participants were measured before and after the retreat or vacation and 1-month and 12 months later for depression, stress, mindfulness, vitality, and blood was drawn for genetic analysis.

They found that all three groups showed significant improvements in depression, stress, mindfulness and vitality after the treatment, which was maintained 1-month later, while the novice meditators on the retreat maintained the improvements in depression and stress at the 10-month follow-up. There were marked changes in gene expressions that were present in all groups that included genes involved in the suppression of stress-related responses and immune function related to acute-phase wound healing and inflammation. Hence, the retreat and the vacation produced change in gene expressions that reflected lower stress, wounding, and inflammation, all of which signal improved health and well-being. In addition, the experienced meditator group showed increased expression for genes associated with healthy aging and in increased telomerase levels. Hence, meditation appears to promote healthy aging and longevity by protecting the telomeres from shortening which signals aging.

These are outstanding results and demonstrate that a week’s break either in the form of a meditation retreat or as a simple vacation produces improved mental health and vitality and decreased stress and gene expressions reflecting reduced stress and inflammation. This is a marked endorsement of the importance of a vacation to the individual’s health and well-being. But, the addition of meditation produces additional benefits which signal healthy aging and longevity. This is a marked endorsement of meditation retreat to not only improve current well-being but also to produce healthier aging.

So, improve cellular molecular health with a meditation retreat.

“At the retreat, the teacher warned us over and over not to look for major shifts in our lives when we got home. But my constellation of little changes seemed just evidence, really, that with continuous effort, I could change the way my mind worked. I could decouple, however briefly, my sense of self from the meat sack of mind and body. And that decoupling gave me the ability to actually control where that sack was headed next.” – Zoe Schlanger

Meditation is becoming increasingly practiced, especially for stress-related medical conditions. Meditation may improve cellular health; however, studies have not separated out effects of meditation from vacation-like effects in a residential randomized controlled trial. We recruited healthy women non-meditators to live at a resort for 6 days and randomized to either meditation retreat or relaxing on-site, with both groups compared with ‘regular meditators’ already enrolled in the retreat. Blood drawn at baseline and post intervention was assessed for transcriptome-wide expression patterns and aging-related biomarkers. Highly significant gene expression changes were detected across all groups (the ‘vacation effect’) that could accurately predict (96% accuracy) between baseline and post-intervention states and were characterized by improved regulation of stress response, immune function and amyloid beta (Aβ) metabolism. Although a smaller set of genes was affected, regular meditators showed post-intervention differences in a gene network characterized by lower regulation of protein synthesis and viral genome activity. Changes in well-being were assessed post intervention relative to baseline, as well as 1 and 10 months later. All groups showed equivalently large immediate post-intervention improvements in well-being, but novice meditators showed greater maintenance of lower distress over time compared with those in the vacation arm. Regular meditators showed a trend toward increased telomerase activity compared with randomized women, who showed increased plasma Aβ42/Aβ40 ratios and tumor necrosis factor alpha (TNF-α) levels. This highly controlled residential study showed large salutary changes in gene expression networks due to the vacation effect, common to all groups. For those already trained in the practice of meditation, a retreat appears to provide additional benefits to cellular health beyond the vacation effect

“It had been traditionally assumed that personality traits are relatively stable entities, but more recent research demonstrates that personality, including disposition towards mindfulness, can change over time as a result of life experiences or through mindfulness practice.” – Yi‑Yuan Tang

The genes dictate all of the chemical processes in our bodies including brain development and plasticity. One gene, in particular, encodes the production of brain-derived neurotrophic factor (BDNF). It is a protein found in the brain and spinal cord that promotes the survival of nerve cells by playing a role in the growth, maturation, and maintenance of these cells. In the brain, the BDNF protein is active at the connections between nerve cells (synapses), where cell-to-cell communication occurs. The synapses can change and adapt over time in response to experience, a characteristic called neuroplasticity. The BDNF protein helps regulate neuroplasticity, which is important for learning and memory.

Since BDNF is involved in the development of the nervous system, and the nervous system, in part, determines our personality characteristics, it would seem reasonable to suspect that the genes underlying BDNF production would be associated with personality. In addition, since BDNF is involved in the plasticity of the nervous system, its ability to change and adapt to the environment and experience, it would seem reasonable to suspect that the genes underlying BDNF production would be associated with variations in brain neuroplasticity. The genes underlying BDNF production have a major variant that is present in approximately 25% of the population. It is possible that this variant may be responsible, in part, for differences between people in personality and neuroplasticity.

This reasoning taken together with the facts that mindfulness practices, including meditation, yoga, tai chi, qigong, are known to change the nervous system through neuroplasticity and are known to change some aspects of personality, it would seem reasonable to suspect that different variants of the genes underlying BDNF production would be associated with differences in the ability of mind body practices to change the brain and personality. This complex logic leads to the idea that differences in BDNF gene variants may produce different personality changes in response to mind-body practices.

In today’s Research News article “Effects of Mind-Body Training on Personality and Behavioral Activation and Inhibition System According to BDNF Val66Met Polymorphism.” See:

Jung and colleagues examine this hypothesis. They recruited a group of participants who regularly practiced Brain Wave Vibration, a practice that is a movement based meditation resembling yoga, martial arts, and meditation. They also recruited a group who did not engage in mind-body practices. Both groups were separated into subgroups based upon whether they carried the normal or the variant of the BDNF gene. All participants were measured for personality and behavioral activation/inhibition.

They found that the BDNF gene variant affected personality with control participants who had the variant higher in neuroticism and lower in extroversion. Neuroticism is known to be associated with personality problems and mental illness. So, these results suggest that the BDNF gene variant produces personality problems. On the other hand, those participants who engaged in mind-body practices and had the BDNF gene variant were higher in extroversion and openness to experience than the control participants who also had the BDNF gene variant. These results are complex but indicate firstly that the genes are involved in the determination of personality characteristics and secondly that they modify the ability of mind-body practices to change personality. They also show that engagement in mind-body practices can, to some extent, help to correct personality problems resulting from the individual’s inheritance.

OBJECTIVE: It has been known that mind-body training (MBT) can affect personality and behavior system as well as emotional well-being, but different effects of MBT on them has not been reported according to BDNF genetic polymorphism.

RESULTS: In the same genotypes of the BDNF Val/Val+Val/Met group, MBT group showed the increased Extraversion (p=0.033) and the increased Openness to Experience (p=0.004) compared to the control group. Also, in the same Met/Met carriers, MBT group exhibited the increase of Extraversion (p=0.008), the reduction of Neuroticism (p=0.002), and the increase of Openness to Experience (p=0.008) compared to the control group. In the same genotypes of the BDNF Val/Val+Val/Met group, MBT group showed the decreased BAS-Reward Responsiveness (p=0.016) and the decrease of BIS (p=0.004) compared to the control group. In the BDNF Met/Met group, MBT group increased BAS-Fun Seeking (p=0.045) and decreased BIS (p=0.013) compared to the control group.

CONCLUSION: MBT would differently contribute to NEO personality and BAS/BIS according to BDNF genetic polymorphism, compensating for different vulnerable traits based on each genotype.

“I don’t think anybody would argue that fact that we know inflammation in the body, which comes from a lot of different sources, is the basis for a lot of chronic health problems, so by controlling that, we would expect to see increased life expectancy … but if we’re not changing those things and just taking ibuprofen, I don’t know if we’re really going to make any headway in that, I feel like there are probably a lot of factors that we could change without medicating with risk.”– Josie Znidarsic

The immune system is designed to protect the body from threats like stress, infection, injury, and toxic chemicals. One of its tools is the Inflammatory response. Its primary effect is to increase blood circulation around the infected area, dilating the blood vessels around the site of inflammation. It also produces gaps in the cell walls surrounding the infected area, allowing the larger immune cells, to pass. It also tends to increase body temperature to further fight infection. This response works quite well for short-term infections and injuries and as such is an important defense mechanism for the body. But when inflammation is protracted and becomes chronic, it can itself become a threat to health.

Chronic inflammation can produce autoimmune diseases such as colitis, Chron’s disease, arthritis, heart disease, increased cancer risk, lung disease, sleep disruption, gum disease, decreased bone health, psoriasis, and depression. Needless to say chronic inflammation can create major health problems. Indeed, the presence of chronic inflammation is associated with reduced longevity. So, it is important for health to control the inflammatory response, allowing it to do its job in fighting off infection but then reducing its activity when no external threat is apparent.

Contemplative practices appear to relax the physical systems of the body including the immune system, reducing inflammation. Mind-body techniques such as yoga, Tai Chi and meditation have been shown to adaptively reduce the inflammatory response (see http://contemplative-studies.org/wp/index.php/category/research-news/inflammatory-response/). In today’s Research News article “Mind-body therapies and control of inflammatory biology: A descriptive review”

Bower and colleagues review the published research literature on the effects of mind-body practices on the inflammatory response. They found mixed and inconclusive results for circulating and cellular markers of inflammation but consistent findings for gene expression inflammatory pathways. These studies consistently demonstrated that mind-body practices including tai chi, yoga, and meditation produced a decrease in inflammatory gene expressions and does so in diverse populations of practitioners.

Regardless of the explanation, it is clear that mindfulness practices reduce potentially harmful inflammatory responses. So, mindfully control inflammation.

“The mindfulness-based approach to stress reduction may offer a lower-cost alternative or complement to standard treatment, and it can be practiced easily by patients in their own homes, whenever they need.” – Melissa Rosenkranz

There is an accumulating volume of research findings to demonstrate that Mind-body therapies have highly beneficial effects on the health and well-being of humans. These include meditation, yoga, tai chi, qigong, biofeedback, progressive muscle relaxation, guided imagery, hypnosis, and deep breathing exercises. Because of their proven benefits the application of these practices to relieving human suffering has skyrocketed.

The genes dictate all of the chemical processes in our bodies including immune and inflammatory responses. So, it would seem reasonable to investigate whether alterations in gene expressions might be the intermediary between mind-body therapies and health. In today’s Research News article “Functional Genomics in the Study of Mind-Body Therapies”

Niles and colleagues review the literature on the effects of mind-body therapies on the functional expression of the genes. Out of the vast number of genomic pathways that can be affected, they found one which appears to be altered by mind-body therapies in general. This was a reduction in activity (downregulation) of the expression of genes that elicit the inflammatory response. In other words mindfulness practices reduce inflammation by reducing the activity of the genes that produce it.

This finding is extremely important as an overactive inflammatory system underlies many chronic diseases. Inflammation is a normal response of the body to outside threats like stress, infection, injury, and toxic chemicals. It is designed to protect the body and ward off these threats. It works quite well for short-term infections and injuries and as such is an important defense mechanism for the body. But when inflammation is protracted and becomes chronic, it can itself become a threat to health. Chronic inflammation can produce autoimmune diseases such as colitis, Chron’s disease, arthritis, heart disease, increased cancer risk, lung disease, sleep disruption, gum disease, decreased bone health, psoriasis, and depression. Needless to say chronic inflammation can create major health problems. Indeed, the presence of chronic inflammation is associated with reduced longevity. So, it is important for health to control the inflammatory response, allowing it to do its job in fighting off infection but then reducing its activity when no external threat is apparent. Mind-body therapies appear to do just that by reducing the expression of the genes that produce inflammation.

All of these results suggest that mind-body therapies promote health and well-being by altering gene expression. This is interesting and important. The next question is what are the mechanisms by which these practices affect gene expressions? It will be up to future research to investigate this link in the causal chain from mind-body therapies to the promotion of health and well-being.

So engage in mind-body practices, change gene expression and promote health and well-being.

“Our genes are quite dynamic in their expression and …. the calmness of our mind can actually have a potential influence on their expression.” – Richard Davidson

Waszczuk and colleagues investigated the genetic and environmental determination of mindfulness, anxiety, and depression using a twin model including identical and fraternal twins. They found that low mindfulness was associated with high levels of anxiety and depression. They also found that there were significant influences of both heredity and environment on all three characteristics. In addition, they found that common genetic influences explained most of the association between low mindfulness, depressive symptoms, and anxiety sensitivity. In other words, not only was depression and anxiety related to low mindfulness, and that each of the characteristics were influenced by heredity, but also the relationship between them was also influenced by heredity.

It is important to keep in mind that although heredity was found to be an important contributor to each of these characteristics and their relationships, there were also significant environmental contributors. Hence, although biology, influenced by the genes is an important determinant, the environment is also. This suggests that environmental interventions such as mindfulness training could alter these characteristics and their relationships.

These are interesting and important observations. They go a long way toward explaining why people are so different in their inherent levels of mindfulness, anxiety and depression. They also help us to understand why different people may respond differently to mindfulness training for anxiety and depression.