paxillin

paxillin

(pak'sĭl-in),

A 68-kD cytoskeletal protein containing multiple domains that appears to participate in actin-membrane attachment at sites of cell adhesion to the extracellular matrix. It may also be involved in the regulation of the growth and organization of the cytoskeleton.

Downstream signaling molecules are also activated, including p21 activated kinase, Akt, Cdc42, and protein kinase C, as well as focal adhesion kinase, Pyk2, paxillin, and extracellular signal-regulated kinase; all these are important in the adhesion process, leading to modulation of cell migration.

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