New Orleans' filmmaking Duplass brothers are back in town, preparing next week to start a six-week local shoot on the Paramount-backed comedy "Jeff Who Lives at Home," and they've brought some high-profile names to lend a hand.

Jason Segel, shown in a scene from 'Forgetting Sarah Marshall,' has been cast in the New Orleans-shot quest comedy 'Jeff Who Lives at Home,' which will be directed by the Duplass brothers. Comic actors Jason Segel ("How I Met Your Mother," "Forgetting Sarah Marshall") and Ed Helms ("The Office," "The Hangover") have been added to the project, Metairie natives and Jesuit High School graduates Mark and Jay Duplass said Monday (April 5) in an interview at the local production office for "Jeff."

Joining them in the cast will be Judy Greer ("27 Dresses") and another New Orleans product, actor and frequent Duplass collaborator Steve Zissis, who has acted in Duplass projects including "The Puffy Chair," "Baghead" and "Cyrus."

"We've got a couple of other names in the works," Jay Duplass said. "We can't say just yet."

Segel will play the title role in the comic quest movie -- in which an errand for his mother springboards him into "an epically small adventure through the suburbs" -- with Helms playing a supporting role as Jeff's "curmudgeonly, ornery older brother Pat."

No release date has been set for "Jeff Who Lives at Home," although the Duplasses are looking toward a release in spring 2011.