Fusion

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Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:query proteins and first shell of interactors

white nodes:second shell of interactors

Node Content

empty nodes:proteins of unknown 3D structure

filled nodes:some 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

RB2654_02144

Sarcosine oxidase, alpha subunit family protein (1004 aa)

Predicted Functional Partners:

gcvP

Glycine dehydrogenase (aminomethyl-transferring) ; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (953 aa)

0.999

RB2654_02149

Putative sarcosine oxidase gamma subunit (182 aa)

0.999

RB2654_02139

Putative sarcosine oxidase delta subunit protein (107 aa)

0.999

gcvH

Glycine cleavage system H protein ; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (119 aa)

0.998

RB2654_02129

Sarcosine oxidase, beta subunit family protein (415 aa)

0.998

RB2654_05220

Dihydrolipoamide acetyltransferase (467 aa)

0.993

RB2654_08672

Aminomethyl transferase family protein (833 aa)

0.993

glyA

Serine hydroxymethyltransferase ; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (430 aa)

a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1

node2

node1 accession

node2 accession

node1 annotation

node2 annotation

score

RB2654_02129

RB2654_02139

RB2654_02129

RB2654_02139

Sarcosine oxidase, beta subunit family protein

Putative sarcosine oxidase delta subunit protein

0.995

RB2654_02129

RB2654_02144

RB2654_02129

RB2654_02144

Sarcosine oxidase, beta subunit family protein

Sarcosine oxidase, alpha subunit family protein

0.998

RB2654_02129

RB2654_02149

RB2654_02129

RB2654_02149

Sarcosine oxidase, beta subunit family protein

Putative sarcosine oxidase gamma subunit

0.992

RB2654_02129

RB2654_08672

RB2654_02129

RB2654_08672

Sarcosine oxidase, beta subunit family protein

Aminomethyl transferase family protein

0.961

RB2654_02129

RB2654_10803

RB2654_02129

RB2654_10803

Sarcosine oxidase, beta subunit family protein

Putative aromatic-ring hydroxylating dioxygenase, alpha-subunit

0.779

RB2654_02129

RB2654_10808

RB2654_02129

RB2654_10808

Sarcosine oxidase, beta subunit family protein

Uncharacterized protein

0.867

RB2654_02129

gcvP

RB2654_02129

RB2654_18563

Sarcosine oxidase, beta subunit family protein

Glycine dehydrogenase (aminomethyl-transferring) ; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein

0.853

RB2654_02129

glyA

RB2654_02129

RB2654_20773

Sarcosine oxidase, beta subunit family protein

Serine hydroxymethyltransferase ; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism

0.879

RB2654_02139

RB2654_02129

RB2654_02139

RB2654_02129

Putative sarcosine oxidase delta subunit protein

Sarcosine oxidase, beta subunit family protein

0.995

RB2654_02139

RB2654_02144

RB2654_02139

RB2654_02144

Putative sarcosine oxidase delta subunit protein

Sarcosine oxidase, alpha subunit family protein

0.999

RB2654_02139

RB2654_02149

RB2654_02139

RB2654_02149

Putative sarcosine oxidase delta subunit protein

Putative sarcosine oxidase gamma subunit

0.998

RB2654_02139

RB2654_08672

RB2654_02139

RB2654_08672

Putative sarcosine oxidase delta subunit protein

Aminomethyl transferase family protein

0.982

RB2654_02139

RB2654_10803

RB2654_02139

RB2654_10803

Putative sarcosine oxidase delta subunit protein

Putative aromatic-ring hydroxylating dioxygenase, alpha-subunit

0.793

RB2654_02139

RB2654_10808

RB2654_02139

RB2654_10808

Putative sarcosine oxidase delta subunit protein

Uncharacterized protein

0.900

RB2654_02139

gcvP

RB2654_02139

RB2654_18563

Putative sarcosine oxidase delta subunit protein

Glycine dehydrogenase (aminomethyl-transferring) ; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein

0.854

RB2654_02139

glyA

RB2654_02139

RB2654_20773

Putative sarcosine oxidase delta subunit protein

Serine hydroxymethyltransferase ; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism

0.902

RB2654_02144

RB2654_02129

RB2654_02144

RB2654_02129

Sarcosine oxidase, alpha subunit family protein

Sarcosine oxidase, beta subunit family protein

0.998

RB2654_02144

RB2654_02139

RB2654_02144

RB2654_02139

Sarcosine oxidase, alpha subunit family protein

Putative sarcosine oxidase delta subunit protein

0.999

RB2654_02144

RB2654_02149

RB2654_02144

RB2654_02149

Sarcosine oxidase, alpha subunit family protein

Putative sarcosine oxidase gamma subunit

0.999

RB2654_02144

RB2654_05220

RB2654_02144

RB2654_05220

Sarcosine oxidase, alpha subunit family protein

Dihydrolipoamide acetyltransferase

0.993

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Network Stats

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Functional enrichments in your networkNote: some enrichments may be expected here (why?)

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Statistical background

For the above enrichment analysis, the following statistical background is assumed: