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P23 - The role of TRPM8 in the systemic regulation of energy metabolism

Obesity and diabetes are major health threats of our society, annually leading to more than 1.5 million deaths. Preliminary data from our group show the TRP channel TRPM8 regulates systemic energy and glucose metabolism. The overall aim of this proposal is to identify the key metabolic organs and signaling mechanisms underlying systemic energy balance regulation by TRPM8 and to assess the druggability of TRPM8 pathway modulation for the treatment of obesity and diabetes.