I have a Quark 2017 print layout document, and in the document there are many url's listed. Is there a way to output a pdf where the links are all active? I really don't want to have to create all the entries in the hyperlinks palette manually, then select each one.

If you have QuarkXPress 2018, you can do this in a single click. You need to run the "convert text to hyperlinks" script from the JavaScript palette. You may download the 7-day test drive and try it yourself.