Chalcone/stilbene synthase, active site (IPR018088)

Short name:
Chalcone/stilbene_synthase_AS

Description

Chalcone synthases (CHS) (EC:2.3.1.74) and stilbene synthases (STS) (formerly known as resveratrol synthases) are related plant enzymes. CHS is an important enzyme in flavanoid biosynthesis and STS is a key enzyme in stilbene-type phyloalexin biosynthesis. Both enzymes catalyse the addition of three molecules of malonyl-CoA to a starter CoA ester (a typical example is 4-coumaroyl-CoA), producing either a chalcone (with CHS) or stilbene (with STS) [PMID: 2184816].

These enzymes have a conserved cysteine residue, located in the central section
of the protein sequence, which is essential for the catalytic activity of both
enzymes and probably represents the binding site for the 4-coumaryl-CoA group
[PMID: 2033084].