During his production position at Warner Bros., he originally received no on-screen credit, similar to his two predecessors after Leon Schlesinger retired in 1944. In 1963, he began to receive on-screen credit with new producer (and former director) Friz Freleng. Around this time, they formed DePatie-Freleng Enterprises, also known as DePatie-Freleng Entertainment, and known on-screen as "DFE Films".

Chuck Jones was producing Dr. Seuss specials for Metro-Goldwyn-Mayer, until MGM shut down the animation studio. DePatie-Freleng picked up production of The Cat in the Hat. Music was composed by Dean Elliott for four Dr. Seuss specials, Hawley Pratt directed three specials, and Maurice Noble was production designer for three specials. Chuck Jones co-produced with Ted Geisel while DePatie and Freleng were executive producers for The Cat in the Hat only. Since Jones was working for ABC, he no longer worked on any more Dr. Seuss specials. Freleng and Ted Geisel became producer but were credited separately. DePatie was the only one credited as executive producer. Music was scored by Joe Raposo for three later specials. DePatie-Freleng's last Dr. Seuss special was The Grinch Grinches the Cat in the Hat, which was around the time that DFE became part of Cadence Industries, and rebranded as Marvel Productions.