The invention provides a manufacturing management system-oriented high-efficiency large-scale event detection and handling method. An event triggering way comprises multiple modes including detection message-based event triggering, detection equipment parameter-based event triggering and the like. Events are handled according to specified logics after being triggered, and the handling results of the events are issued to event subscription ends. According to the manufacturing management system-oriented high-efficiency large-scale event detection and handling method provided by the invention, by adopting the distributed software technology, event detection and handling modules are deployed by multiple nodes all nodes bear different event handling tasks, and thus, loads of all the nodes can be effectively balanced, the real-time and high-efficiency detection and handling of large-scale concurrent events are realized, and the events are ensured to be at a millisecond level from production to response, so that a production manager knows the information of alarm, a material status and an equipment status during production in time, the production efficiency is effectively improved, and the production cost is reduced.