SBML generated from Reactome version 70 on 9/15/19 12:53 PM using JSBML version 1.3.1.

After passing through the Golgi complex, secretory cargo is packaged into post-Golgi transport intermediates (post-Golgi), which translocate plus-end directed along microtubules to the plasma membrane. There at least two classes of clathrin coated vesicles in cells, one predominantly Golgi-associated, involved in budding from the trans-Golgi network and the other at the plasma membrane. Here the clathrin-coated vesicles emerging from the Golgi apparatus are triggered by the heterotetrameric adaptor protein complex, AP-1 at the trans-Golgi network membrane. The cargo can be transmembrane, membrane associated or golgi luminal proteins. Each step in the vesicle sculpting pathway, gathers cargo and clathrin triskeletons, until a complete vesicular sphere is formed. With the scission of the membrane the vesicle is released and eventually losses its clathrin coat.

GillespieMarc ENYU School of Medicine, Department of Biochemistry

GillespieMarc ENYU School of Medicine, Department of Biochemistry

Weiser

2007-07-13T20:42:29Z2019-08-19T23:21:57Z2008-05-21T20:31:41Z

Derived from a Reactome Complex. Here is Reactomes nested structure for this complex: (O00161, Q12846, P63027). Reactome uses a nested structure for complexes, which cannot be fully represented in SBML Level 3 Version 1 core

Derived from a Reactome EntityWithAccessionedSequence. This is a protein

Derived from a Reactome EntityWithAccessionedSequence. This is a protein

Derived from a Reactome EntityWithAccessionedSequence. This is a protein

Derived from a Reactome EntityWithAccessionedSequence. This is a protein

The vamp2 associated vesicle docks and fuses with the plasma membrane.