SUBSTANCE: invention describes a method for producing Sel-Plex nanocapsules possessing the supramolecular properties by non-solvent addition, characterised by the fact that Sel-Plex is dissolved in dimethyl sulphoxide; the prepared mixture is dispersed in xanthum gum solution used as a nanocapsule shell, in butanol, in the presence of E472c preparation while stirring at 1000 cycles per second; the mixture is added with the precipitator benzol, filtered and dried at room temperature.

EFFECT: simplifying and accelerating the process of nanoencapsulation and ensuring higher weight yield.

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The invention relates to the field of nanotechnology and veterinary medicine, in particular nanocapsules SEL-Plex with supramolecular properties. SEL-Plex selenium found primarily in the composition of the amino acids Selenomethionine and selenocystine. Increases antioxidant status of the organism and survival of young, supports and increases the motility and fertilizing capacity of sperm, improves productivity in the presence of mycotoxins in feed, improves the condition of the plumage. Used in the manufacture of mixed fodders and premixes as a source of Se instead of sodium Selenite and other inorganic compounds of this element for all animal species.

Previously known methods for producing microcapsules of drugs. So, in us Pat. 2092155, IPC A61K 047/02, A61K 009/16 published 10.10.1997, the Russian Federation proposed a method for microencapsulation of drugs, based on the use of irradiation with ultraviolet rays.

The disadvantages of this method are the duration of the process and application of ultraviolet radiation, which can influence the formation of microcapsules.

In us Pat. 2091071, IPC A61K 35/10, Russian Federation, published 27.09.1997 a method of producing the drug by dispersing in a ball mill to obtain microcapsules.

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The disadvantage of this method is the application of the ball mill and the duration of the process.

In us Pat. 2101010, IPC A61K 9/52, A61K 9/50, A61K 9/22, A61K 9/20, A61K 31/19, Russian Federation, published 10.01.1998 proposed chewable form of the drug with taste masking, having the properties of a controlled release drug product that contains microcapsules with a size of 100-800 microns in diameter and consists of pharmaceutical kernel crystalline ibuprofen and polymeric coating comprising a plasticizer, elastic enough to resist chewing. Polymer coating is a copolymer based on methacrylic acid.

Disadvantages of the invention: use of a copolymer based on methacrylic acid, as these polymer coatings can cause cancer; the difficulty of execution; the duration of the process.

In us Pat. 2173140, IPC A61K 009/50, A61K 009/127, Russian Federation, published 10.09.2001 a method of producing kremnijorganicheskih microcapsules using a rotary cavitation equipment with high shear forces and powerful hydroacoustic phenomena sonic and ultrasonic range for dispersion.

The disadvantage of this method is the use of special equipment - rotary-cavitational installation, which possesses�AET ultrasonic action,
what influences the formation of the microcapsules and thus may cause adverse reactions due to the fact that ultrasound has a destructive effect on polymers of protein nature, therefore, the proposed method is applicable when working with polymers of synthetic origin.

In us Pat. 2359662, IPC A61K 009/56, A61J 003/07, B01J 013/02, A23L 001/00 published 27.06.2009, the Russian Federation proposed a method of producing microcapsules using spray cooling in the spray tower Niro under the following conditions: air temperature at the inlet 10°C, the temperature at the outlet 28°C, the speed of rotation of the spray drum 10000 rpm/min Microcapsules according to the invention have improved stability and provide adjustable and/or prolonged release of the active ingredient.

The disadvantages of the proposed method are the duration of the process and the use of special equipment, certain set of conditions (the air temperature at the inlet 10°C, the temperature at the outlet 28°C, the speed of rotation of the spray drum 10000 rpm).

The closest method is the method proposed in us Pat. 2134967, IPC A01N 53/00, A01N 25/28, published 27.08.1999 G., Russian Federation (1999). In water dispersed solution of a mixture of natural lipids and PYRETHROID insecticide in a weight ratio of 2-4:1 in an organic solvent, copepodid to simplify the method of microencapsulation.

The disadvantage is the dispersion in an aqueous medium, which makes the proposed method applicable for obtaining microcapsules of water-soluble drugs in water-soluble polymers.

The technical objective is the simplification and acceleration of the process of producing nanocapsules, reducing loss upon receipt of the microcapsules (increase of the yield by weight).

The solution of a technical problem is achieved by a method of encapsulating SEL-Plex, characterized in that as the shell of the nanocapsules xanthan gum is used when receiving physical-chemical method for the deposition nerastvorim using precipitator - benzene, the process is carried out without special equipment.

A distinctive feature of the proposed method is the use of xanthan gum as the shell of the nanocapsules SEL-Plex as their nucleus, and the use of precipitator - benzene.

The result of the proposed method is to obtain nanocapsules SEL-Plex in xanthan gum for 20 minutes. The output of the nanocapsules is over 90%.

Fig.1 shows confocal images of fractal compositions from solution nanocapsules SEL-Plex in the shell xanthan gum (ratio of sheath:core 3:1) at a concentration of 0.25% that: a) the increase in 505 times, b) the increase in 620 times) increase in 930 times, g) took�argument in 1200 times
d) an increase in 1770 times, (e) increase in 2830 times.

EXAMPLE 1. Obtaining nanocapsules SEL-Plex with the dissolution of the drug in dimethyl sulfoxide (DMSO), the ratio of the core/polymer 1:3

100 mg SEL-Plex suspension in 1 ml DMSO and the resulting mixture is dispersed in a solution of xanthan gum in butanol containing the specified 300 mg of the polymer in the presence of 0.01 g of the drug Is (an ester of glycerol with one or two molecules of dietary fatty acids and one or two molecules of citric acid, and citric acid as tribasic can be etherification other glycerides and as oxanilate - other fatty acids. Free acid groups can be neutralized with sodium) under stirring about 1000/s. Next, pour 4 ml of benzene and 1 ml of distilled water. The resulting suspension was filtered and dried at room temperature.

Received 0,396 g of a white powder. The yield was 99%.

EXAMPLE 2. Obtaining nanocapsules SEL-Plex with the dissolution of the drug in dimethyl sulfoxide (DMSO), aspect]�the determination of the core/polymer 1:2

100 mg SEL-Plex dissolved in 1 ml DMSO and the resulting mixture is dispersed in a solution of xanthan gum in butanol containing specified 200 mg of the polymer in the presence of 0.01 g of the drug Is under stirring about 1000/s. Next, pour 3 ml of benzene and 1 ml of distilled water. The resulting suspension was filtered and dried at room temperature.

Received 0,297 g of a white to yellowish powder. The yield was 99%.

EXAMPLE 3. Obtaining nanocapsules SEL-Plex with the dissolution of the drug (DMSO), the ratio of the core/polymer 1:1

100 mg SEL-Plex dissolved in 1 ml DMSO and the resulting mixture is dispersed in a solution of xanthan gum in butanol containing specified 100 mg of the polymer in the presence of 0.01 g of the drug Is under stirring about 1000/s. Next, pour 2 ml of benzene and 1 ml of distilled water. The resulting suspension was filtered and dried at room temperature.

Received 0,190 g of a white to yellowish powder. The yield was 95%.

EXAMPLE 4. Investigation of self-nanocapsules from solutions

From the powder of nanocapsules obtained according to the method described in the examples, there were prepared aqueous solutions of concentrations 1%, 0,5%, 0,25%, 0,125% etc. by dilution of the solution twice. A drop of each of the prepared solutions were placed on a glass slide prior to complete drying and dried over�spine was performed confocal scanning microscopy.

The formation of nanocapsules occurs spontaneously through non-covalent interactions and this suggests that they are characterized by self-Assembly. Shown in Fig.1, 2 patterns are ordered, so they are self-organizing. Consequently, encapsulated SEL-Plex has a supramolecular properties.

The obtained nanocapsules Villages of the Complex physico-chemical deposition method by nerastvorim using precipitator - benzene, which increases output and accelerates the process of nanocapsule. The process is simple to perform and lasts for 20 minutes, requires no special equipment.

The proposed method is suitable for the veterinary industry due to the minimal loss of speed, ease of obtaining and allocation of nanocapsules.

A method of producing nanocapsules SEL-Plex with supramolecular properties, by deposition of aristotelem, characterized by the fact that SEL-Plex was dissolved in dimethylsulfoxide and the resulting mixture is dispersed in a solution of xanthan gum that is used as the shell of the nanocapsules, in butanol, in the presence of the drug As with stirring at 1000 Rev/s, then pour the precipitator - benzene, filtered off and dried at room temperature.

SUBSTANCE: ceramic membrane, applied for the separation of gas mixtures, has the following composition, wt %: aluminium oxide 30-54; sodium silicate 42-68; carbon nanotubes CNT with an external diameter of 1-5 nm with a three-layer structure and a specific surface of 350-1000 m2/g 1-4. The method of preparing the ceramic membrane for the separation of gas mixtures includes mixing of thermoactivated gibbsite - Al(OH)3 with sodium silicate and the carbon nanotubes CNT with an external diameter of 1-5 nm with the three-layer structure and the specific surface of 350-1000 m2/g, following addition of a nitric acid solution. The obtained mass is thoroughly mixed and an excess of moisture is removed until powder has a half-dry condition. The obtained powder is pressed, the pressed tablets are subjected to thermal-processing - first, they are exposed at a temperature of not higher than 150°C, then at a temperature of not higher than 400°C. The obtained membrane in the form of a tablet is annealed without air access at 850-1100°C.

SUBSTANCE: invention relates to electronics and is intended to design devices which convert the chemical reaction of adsorbed molecules of a fuel gas (vapour) and oxygen (or air) into an electrical signal. The invention can be used to design compact batteries for electronic equipment in the form of single-chamber fuel cells, which consist of a working chamber having a fuel-gas mixture inlet and a gas outlet, inside of which there is a composite film with electrical contacts connected to an external load, the space between which is filled with a conducting material. The conducting material used is a nanocomposite material which consists of a non-conducting polymer film of polypropylene and conducting filler in the form of carbon nanotubes. Concentration of the carbon nanotubes with p-type conductivity is about 0.5-5% near the percolation threshold. The nanocomposite material may contain catalytic nanoparticles of Pt or Pd, or Rh, or Ru. Also disclosed is a method of producing a conducting nanocomposite material, which includes mixing carbon nanotubes and polymer material and then holding the nanocomposite material at external voltage of 4-10 V for 2-30 min in an atmosphere of saturated acetone vapour.

SUBSTANCE: invention refers to medicine and describes a method for producing chondroitin sulphate nanocapsules by non-solvent addition, characterised by the fact that chondroitin sulphate is added in small portions into xanthane gum suspension used as a nanosuspension shell, in butanol containing 0.01 g of the preparation E472 as a surfactant; the produced mixture is stirred and added with the nonsolvent hexane 6ml, filtered, washed in hexane and dried.

SUBSTANCE: invention represents a method for drug encapsulation by non-solvent addition, wherein according to the invention cores of nanocapsules are vitamins, whereas a shell is sodium carboxymethyl cellulose precipitated from isopropyl alcohol suspension by adding chloroform as a non-solvent and dried at room temperature.

SUBSTANCE: invention relates to field of biotechnology. Method of extracting DNA from blood cells is claimed. Magnetic particles and ferromagnetic nanospheres CoNiFe2O4 50 nm are added into sample. Biologic material is lysed. DNA is washed and DNA is taken off from carrier.

SUBSTANCE: invention relates to formation methods of independent self-cooled instruments and elements of electronics, which can operate effectively without using any liquid nitrogen technology and other cryogenic equipment. The formation method of an independent self-cooled nanoinstrument consists in the fact that on a substrate from monocrystalline material with a squid receiver formed on one side there arranged on the reverse side is a heat absorption device that includes a cathode and an anode, which have different Fermi energy of electrons. Then, the substrate is enclosed through an installation hole in a vacuum cover from ceramised glass which contains contact electrodes for two substrate sides. After that, the substrate installation hole is closed with a cover from ceramised glass. This device is arranged in a vacuum chamber in which a target from ceramised glass is arranged as well. Pumping-out to the pressure of 10-1 Pa is performed; the target and the cover from ceramised glass is heated up to 450÷500°C. Then, by means of a laser with wavelength of radiation equal to 1.06 mcm, pulse duration of 10-20 ns and pulse repetition frequency of 10 Hz, power density of 5·108÷8·108 W/cm2 there the target from ceramised glass is sprayed, which is located at the distance of 8÷10 mm from the cover from ceramised glass during 10 minutes.

EFFECT: invention provides creation of such design of a squid (a superconducting quantum interference device), in which the following is excluded: degradation of superconducting properties in the air medium, dependence of achievement of operating temperature on use of liquid nitrogen or other external cryogenic units with large dimensions.

SUBSTANCE: invention relates to pigments for white paints and coatings, including temperature-control coatings of spacecraft, and can be used in space engineering, in the construction industry and in various industries for temperature control of devices or processing facilities. The pigment for light-reflecting coatings is obtained by heating at 800°C and with a high vaporised and ground mixture of titanium dioxide microparticles with 7 wt % silicon dioxide nanoparticles.

EFFECT: invention enables to obtain a pigment with high radiation resistance using a simple technique which is efficient compared to similar pigments obtained using prior art.

SUBSTANCE: described is a method of obtaining a composite chitosan-based material, which contains aspartic or glutamine amino acids in a quantity from 2 to 5 wt %, as well as calcium phosphates with a ratio of Ca/P from 1.0 to 1.67. The method consists in barbotage through a suspension of calcium phosphates, obtained in situ in a solution of chitosan and aspartic or glutamic acid, with the following lyophilic drying of the foamed products. Porous matrices can be applied in dentistry, maxillofacial surgery, osteoplastic surgery as implants in the treatment of bone tissue defects.

EFFECT: obtained samples are characterised by a uniform porous structure with the simultaneous reduction of calcium phosphate dimensions to a nano-level with the reduction of the number of material obtaining operations.

SUBSTANCE: invention refers to medicine, namely to a polymer composition for medical devices containing polycarbonate with a degree of polymerisation of n=200-2,000 in an amount of 100 weight fractions, a polymer additive, which is presented by polysulphon at a degree of polymerisation of n=70-150, in an amount of 5 to 40 weight fractions, a complex stabiliser, which is presented by sterically hindered phosphite in an amount of 0.045 to 1.5 weight fractions, a compatibiliser representing maleinised polypropylene in an amount of 0.025 to 5.0 weight fractions, a nanostructured additive representing carbon nanotube superconcentrate with the nanotube content of 20-40 weight fractions in butadiene oligomer with a degree of polymerisation of 6 in an amount of 0.01 to 1.0 weight fractions.

SUBSTANCE: invention represents a method of medication encapsulation by a method of non-solvent precipitation, which differs in the fact, that as a nanocapsules core is applied chondroitin sulphate, as a casing - konjac gum, which is precipitated from a suspension in butyl alcohol due to hexane addition as a non-solvent at 25°C.

EFFECT: simplification and acceleration of the nanocapsules obtaining process, reduction of loss at nanocapsules obtaining.

SUBSTANCE: invention refers to medicine and describes a method for producing chondroitin sulphate nanocapsules by non-solvent addition, characterised by the fact that chondroitin sulphate is added in small portions into xanthane gum suspension used as a nanosuspension shell, in butanol containing 0.01 g of the preparation E472 as a surfactant; the produced mixture is stirred and added with the nonsolvent hexane 6ml, filtered, washed in hexane and dried.

SUBSTANCE: invention represents a method for drug encapsulation by non-solvent addition, wherein according to the invention cores of nanocapsules are vitamins, whereas a shell is sodium carboxymethyl cellulose precipitated from isopropyl alcohol suspension by adding chloroform as a non-solvent and dried at room temperature.

SUBSTANCE: invention represents a method of medication encapsulation by a method of non-solvent precipitation, which differs in the fact, that as a nanocapsules core is applied chondroitin sulphate, as a casing - konjac gum, which is precipitated from a suspension in butyl alcohol due to hexane addition as a non-solvent at 25°C.

EFFECT: simplification and acceleration of the nanocapsules obtaining process, reduction of loss at nanocapsules obtaining.

SUBSTANCE: invention represents method of medication encapsulation by method of precipitation with non-solvent, characterized by the fact that as core of nanocapsules albendazole is applied, as casing - sodium alginate, which is precipitated from suspension in butanol by addition of chloroform as non-solvent at 25°C.

SUBSTANCE: invention provides a method of encapsulating a medicinal preparation via non-solvent addition, characterised by that the core of the microcapsules used is fenbendazole, the envelope used is sodium carboxymethyl cellulose which is deposited from a solution in toluene by adding, as the nonsolvent, carbinol and water at 25°C.

SUBSTANCE: invention provides a method of encapsulating a medicinal preparation via non-solvent addition, characterised by that the core of the microcapsules used is fenbendazole, the envelope used is sodium carboxymethyl cellulose which is deposited from a solution in cyclohexanol by adding, as the nonsolvent, isopropanol and water at 25°C.

SUBSTANCE: invention provides a method of producing microcapsules by non-solvent addition, characterised by that the nucleus of the microcapsules is triazine pesticides and the shell is polyvinyl alcohol, which is deposited from an aqueous solution by adding, as the non-solvent at the beginning, a first precipitant - 5% acetic acid solution in acetone, and then acetone as a second precipitant at 25°C.

EFFECT: simpler and faster process of producing microcapsules of a preparation in water-soluble polymers and higher mass output.

SUBSTANCE: invention represents a method for drug encapsulation by non-solvent addition, differing by the fact that a nanocapsule nucleus is cephalosporin antibiotics; the coating is xanthum gum deposited from a suspension in butanol by adding chloroform as a non-solvent at 25°C.

EFFECT: simplifying and accelerating the nanoencapsulation process, reducing the production loss.

SUBSTANCE: invention refers to medicine and describes a method for producing chondroitin sulphate nanocapsules by non-solvent addition, characterised by the fact that chondroitin sulphate is added in small portions into xanthane gum suspension used as a nanosuspension shell, in butanol containing 0.01 g of the preparation E472 as a surfactant; the produced mixture is stirred and added with the nonsolvent hexane 6ml, filtered, washed in hexane and dried.