This study will evaluate the effect of repeated doses of Niagen™ on Niagen™ metabolite
concentrations in blood, urine and muscle. There will be 3 doses of Niagen™ compared to a
placebo. One quarter of subjects will receive the low dose of Niagen™, one quarter will
receive the moderate dose of Niagen™, one quarter will receive the higher dose of Niagen™
and one quarter will reveive the placebo.

The purpose of this study is to assess the immune memory induced by primary and booster
vaccination with pneumococcal conjugate vaccine GSK1024850A in the first year of life
through evaluation of the immune responses following vaccination with a booster dose of
pneumococcal conjugate vaccine GSK1024850A in the fourth year of life and to assess immune
responses following vaccination with a single dose of pneumococcal conjugate vaccine
GSK1024850A in age-matched unprimed children...

The study intends to establish proof of concept for a fractional dose schedule under
conditions of natural exposure in children 5-17 months old at first vaccination. The study
also aims to establish the role of third dose spacing in a fractional dose schedule, describe
the effect of an earlier full fourth dose at Month 14 and describe the effect of multiple
fractional or full yearly doses.

Proposed action: To investigate the effect of an innovative and easily implementable
football-based health education programme on well-being, self-esteem, health knowledge and
physical fitness for 10-12-year old school children. The programme has been running in 22
countries in Africa and South America and is now being adapted to the Western World. The
first step was to run a pilot implementation for more than 600 school children in Copenhagen,
Frederiksberg, Roskilde and Frede...

This study seeks to determine the optimum dose frequency of 5-Azacytidin (5-AZA) infusions
into the fourth ventricle of the brain. The study's primary objective is to establish the
maximum tolerated dose for infusions of 5-Azacytidine into the fourth ventricle in patients
with recurrent ependymoma. The study's secondary objective is to assess the antitumor
activity of 5-Azacytidine infusions into the fourth ventricle based upon imaging studies and
cytology.

Physical pain is a common but largely overlooked aspect of the lives of the poor. Not only
does pain directly reduce life quality and happiness, it may also hamper cognitive function
and, consequently, decision-making, productivity, and earnings. Workers with chronic pain may
work fewer days, take longer breaks, and make less-considered choices regarding inputs; all
outcomes that would reduce output and lead to greater impoverishment or impede the
productivity and profitability...

This extension protocol is for those subjects that have completed the allowed duration of
participation in an Endocyte-sponsored clinical trial of EC145 and have continuing evidence
of clinical benefit (stable disease or better) at the time that they completed participation
in that study.

This randomised-controlled trial investigates whether a single intervention of manual
pressure release combined with stretching exercise has an effect on muscle length, pain
perception threshold, and respiratory function in subjects with latent myofascial trigger
point in the pectoralis minor muscle or not. First quarter of the participants will receive
a single intervention of manual pressure release combined with contract-relax PNF stretching
exercise of pectoralis minor musc...

The aim of the study is to evaluate the safety and immunogenicity of the 2015-2016
formulations of Fluzone Quadrivalent and Fluzone Intradermal Quadrivalent vaccines in adults
18 to < 65 years of age, and of the 2015-2016 formulations of Fluzone Quadrivalent and
Fluzone High-Dose vaccines in adults ≥ 65 years of age.
Primary Objective:
- To describe the safety of the 2015-2016 formulations of Fluzone Quadrivalent and Fluzone
Intradermal Quadrivalent vaccines in adults...

This is a study evaluating the use of the modified beef tongue model for teaching repair of
obstetrical fourth-degree laceration to residents. Participants will be randomized to either
an instructional video using the modified beef tongue model or to an instructional workshop
using the modified beef tongue model. Primary outcome will be measured as change in technical
skills score as measured by change from baseline on a validated objective structured
assessment of technical sk...

The aim of the study is to describe the safety and immunogenicity of the 2016-2017
formulations of Fluzone Quadrivalent vaccine in children 3 to < 9 years of age and in adults
18 to < 65 years or age, and of the 2016-2017 formulation of Fluzone High-Dose vaccine in
adults ≥ 65 years of age.
Primary Observational Objectives
- To describe the safety of the 2016-2017 formulation of Fluzone Quadrivalent vaccine in
children 3 to < 9 years of age and adults 18 to < ...

Schering Canada plans to collect data on about 3000 to 5000 infliximab infusions per year,
starting in the third quarter of 2005. It is expected that about 12 sites from the Remicade
Infusion Network (R.I.N.) will participate. This registry will be a multicentre,
prospective, observational program that will gather and analyze data on subjects being
treated with infliximab.

An open clinical trial to study the immune response and safety after giving a booster dose
(5th Dose) of a combination vaccine against Diphteria-Tetanus-Pertussis-Polio to healthy
adolescents 15-16 Years of age. The first three doses were given during the first year of
life, according to the Norwegian child immunization program. The fourth dose was given in a
previous clinical trial performed in 1998 when the children were 6-7 years old.
In 2006 there was a change in the child...

In July 2016, the demand for yellow fever vaccines in response to the large urban outbreaks
occurring concurrently and the risk of further spread through the African continent and even
to Asia, was larger than the available supply. In this situation, the World Health
Organization (WHO) developed recommendations for the use of fractional-dose of yellow fever
vaccine as a dose-sparing strategy. These recommendations were based on limited number of
clinical trials and additional s...

The aim of this study is to evaluate FTRD (full-thickness resection device) in terms of
obtaining full-thickness biopsies form the gastrointestinal tract endoscopically in the
work-up of patients with gastrointestinal motility disorders.

The goal of this clinical research study is to learn if infusions of a particular type of
patients' own white blood cells called natural killer (NK) cells can reliably and safely be
given to patients with brain tumors after the cells have been through a procedure to expand
(increase) their numbers.
Researchers also want to learn if NK cells infused through the ommaya reservoir can help to
control the disease in patients with advanced brain tumors. The ommaya reservoir is a
...

After a core biopsy of the tumor is obtained, patients with locally advanced breast cancer
are randomized to receive 4 cycles of full dose doxorubicin (75 mg/m2 e3w) or docetaxel (100
mg/m2 e3w). After the fourth cycle, patients are submitted to surgery to ascertain
pathological response. They then receive the opposite drug, hormones, Herceptin, and
radiation as indicated.

Currently Fisher & Paykel Healthcare (FPH) is developing a new full face mask. The objective
of this clinical investigation is to evaluate the usability and acceptance of the
investigative mask, the effectiveness of the seal and headgear.
The participant will be randomised to use either full face mask prototype 1 or 2 as
according to the randomization log for 7 ± 3 days in home. The participant will then
crossover to the other full face mask prototype to use in home for 7 ± ...

A prospective, multicentre, open-label, randomized, phase 2-3 study to compare the efficacy
and safety of masitinib in combination with FOLFIRI (irinotecan, 5-fluorouracil and folinic
acid) versus Best Supportive Care, in third or fourth line treatment of patients with
metastatic colorectal cancer

To evaluate the efficacy of full thickness placental allograft use in Microdiscectomy
application. To evaluate post-microdiscectomy reherniation rate in patients treated with
full-thickness placental allografts.