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Properties and classes used for protein annotation.A synonym of the recommended name.Attaches an annotation to a resource.based onThe sequence on which the description of a modified sequence is based.111A publication from which data was extracted, or which contains additional information.classified withA concept that classifies this resource.A component of a protein.A domain of a protein.encoded byThe gene by which a protein is encoded.encoded inThe subcellular location where a protein is encoded.enzymeThe catalytic activity associated with a protein. or part of a protein.An erratum for a publication.erratum forThe publication which an erratum refers to.111located onThe molecule a this resource is located on.One of several similar resources.member ofThe experimental method that was used.A modification of a sequence.The organism in which a protein occurs.111A protein that participates in a protein-protein interaction.A range of amino acids.The rank of a taxon.The name recommended by the UniProt consortium.replaced byA resource that replaces this resource.A resource that is replaced by this resource.An amino acid sequence.sequence forA resource that describes this sequence.The reliability of a statement.A name provided by the submitter of the underlying nucleotide sequence.111True if the class does not have any direct instances.catalytic activityThe description of a catalytic activity.An alternative name used in the flat text format.See http://www.expasy.org/cgi-bin/lists?allergen.txtTrue if the protein is divergent in sequence or has mutated functional sites.The author of a publication.The first position of a range.A name used in a biotechnological context.A name from the Human Cell Differentiation Molecules (HCDM) nomenclature.False if there is any uncertainty about a statement.Maps a series of symbols representing chains of a protein to a range of amino acids.An caclulated value that is used to detect if there are errors in the sequence as shown due to among others IO errors. Both the crc64 and md5sum have collisions in UniProt data and cannot be used as unique keys.cofactorA cofactor required for a catalytic activity.common nameThe date a resource was created.The number of domains in a protein that correspond to a family. This is almost always 1, but may be 2 if two identical domains are fused.The ecName is the enzyme classification associated with a structured name of the protein. Proteins are often named after their enzymatic activity but can have more than one activity leading to multiple names.The editor of a publication.The last position of a range.false negativeTrue if a statement is true even though it was not predicted.Indicates if a sequence is complete or consists of one or more fragments.multiplesingleTrue if a sequence modification causes a frameshift.The full name.True if the rule on which the membership of a protein to a family is based does not cover the entire protein.The group or consortium that authored a publication.The number of hits found in a sequence.The level of sequence identity in a cluster.0.50.91.0True if existance of this resource can be inferred.The institution at which a thesis was written.The international nonproprietary name: A generic name for a pharmaceutical substance or active pharmaceutical ingredient that is globally recognized and is a public property.True if the range does not extend beyond the specified endpoint.locus nameThe mass of a sequence in Daltons.A maximum value.measured activityThe maximum velocity, Vmax.measured affinityThe Michaelis-Menten constant, Km.measured errorThe magnitude of the error of a value that was measured.measured valueA value that was measured.A easy to remember identifier for a UniProtKB entry, but it is not a stable identifier and should not be used by programs to identify entries.The date a resource was last modified.nameobsoleteTrue if this resource has been replaced or deleted.A mnemonic that is no longer in use for this entry.ORF nameother nameThe first and last page for a chapter or article.part of lineageTrue for taxa that can appear as part of an organism's lineage.True if the pattern or profile on which the domain assignment is based did not detect the sequence because the sequence is not complete and lacks the region on which the pattern or profile is based.A URL pattern, used to generate links by substituting an identifier.The place where a publication was published. This usually includes a country name.A position on a sequence.The publisher of a book.The resolution of an experiment, in Angstrom.Indicates whether a resource has been reviewed by a curator.scientific nameThe extent of the work carried out by the authors of a publication.An abbreviation of the full name or an acronym.All names of the protein, from commonly used to obsolete, to used in the literature..The database a resource was submitted to.A replacement sequence.The title of a publication.The volume a publication is part of.AbsorptionIndicates the wavelength in nm at which photoreactive proteins such as opsins and DNA photolyases show maximal absorption.Active SiteAmino acid(s) involved in the activity of an enzyme.AllergenInformation relevant to allergenic proteins.Alternative InitiationAlternative ProductsDescription of the existence of related protein sequences produced by alternative splicing of the same gene or by the use of alternative initiation codons.Alternative Promoter UsageSplice VariantDescription of sequence variants produced by alternative splicing.Alternative SplicingDescription of a resource on a specific topic.Entity used to attach evidence or provenance to a rdf statement via reification.StrandBeta strand regions within the experimentally determined protein structureBinding SiteBinding site for any chemical group (co-enzyme, prosthetic group, etc.).Biophysicochemical PropertyBiophysical and physicochemical data such as pH dependence, temperature dependence, kinetic parameters, redox potentials, and maximal absorption.BiotechnologyDescription of the use of a specific protein in a biotechnological process.Book Citation1A chapter from a book.Calcium BindingExtent of a calcium-binding region.Catalytic ActivityDescription of the reactions catalyzed by an enzyme.CautionWarning about possible errors and/or grounds for confusion.Cellular ComponentChainExtent of a polypeptide chain in the mature protein.Description of a publication from which data was obtained.Citation StatementThe relationship between a resource and a citation.Cluster of proteins with similar sequences.CofactorDescription of an enzyme cofactor.Coiled-CoilExtent of a coiled-coil region.Compositionally Biased RegionExtent of a compositionally biased region.ConceptA concept used to classify resources.CrosslinkPosttranslationally formed amino acid bonds.Metadata for a life science database.Developmental StageDescription of the developmentally-specific expression of a protein.DiseaseDiseaseDescription of the diseases associated with a deficiency of a protein.Disruption PhenotypeDisulfide BondDescribes residues which are linked by an intra-chain disulfide bond. If the endpoints are identical, the disulfide bond is an interchain one.DomainDescription of the domain structure of a protein.Domain Assignment StatementThe relationship between a protein and a protein domain.Domain ExtentExtent of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.Electronic Citation1An electronic publication.Endpoint StatementMetadata for an endpoint of a range on a sequence.EnzymeA specific catalytic activity, defined by the Enzyme Commission of the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology (IUBMB).Enzyme RegulationDescription of an enzyme regulatory mechanism.Erroneous Gene Model PredictionErroneous InitiationErroneous TerminationErroneous TranslationExperimental InformationExternal SequenceThe protein described in the linked record is an alternative splice form of the same gene product as described in this record. The function between the two isoforms is highly divergent.Family Membership StatementThe relationship between a protein and a protein family.FrameshiftFunctionGeneral description of the functions of a protein.1Genomic DNAGenomic RNAGlycosylation SiteDescribes the occurrence of the attachment of a glycan (mono- or polysaccharide) to a residue of a protein.HelixHelical regions within the experimentally determined protein structureInductionDescription of the compounds or conditions that stimulate the synthesis of a protein.Initiator MethionineIndicates that the initiator methionine has been cleaved off and is not shown in the sequence.Description of a protein-protein interaction.INTRAMEMExtent of a region located in a membrane without crossing itJournal Citation1An article published in a journal.KineticsMentions the Michaelis-Menten constant (KM) and maximal velocity (Vmax) of enzymes.Known SequenceLipid BindingCovalent binding of a lipid moiety.mRNAMass MeasurementAn experimental method for measuring the mass of a molecule.Mass1Indicates the mass of a sequence determined by mass spectrometry.Metal Ion Binding SiteBinding site for a metal ion.An experimental method.ModificationDescribes amino acid modifications, post pre- and post-translational.Modified ResiduePosttranslational modification of a residue.Modified SequenceA biological molecule.Molecule ProcessingMotifShort (<=20 amino acids) sequence motif of biological interest.Mutagenesis SiteSite which has been experimentally altered.Nucleotide Phosphate BindingExtent of a nucleotide phosphate-binding region.Sequence VariantAuthors report that sequence variants exist.Natural VariationNon-consecutive ResiduesIndicates that two residues in a sequence are not consecutive and that there are a number of unsequenced residues between them.Non standard residueDescribes the occurrence of a non standard residue in the sequence record.Non-terminal ResidueThe residue at an extremity of the sequence is not the terminal residue.falseA class introduced to group all records that are currently in the database.11DNA BindingExtent of a DNA-binding region.Nucleotide Mapping StatementThe relationship between a protein and a nucleotide sequence.Nucleotide Resource1A resource that descripes a nucleotide sequence.Observation CitationCitation of an unpublished result.trueThe class of all obsolete records in the database (i.e. records that where once published but are now removed).Taxa are occasionally removed from the taxonomy database (particularly internal nodes, during a taxonomic revision) – these taxids are deleted, and are not reused.OrganelleOrientationOther DNAOther RNApH DependenceDescribes the optimum pH for enzyme activity and/or the variation of enzyme activity with pH variation.PTMDescription of a posttranslational modification.Description of a part of a protein.A participant in a protein-protein interaction.Patent CitationA patent application.A hierarchical discription of a metabolic pathway.PathwayDescription of the metabolic pathways with which a protein is associated.PeptideExtent of a released active peptide.PharmaceuticalDescription of the use of a protein as a pharmaceutical drug.PolymorphismDescription of polymorphisms.PropeptideExtent of a propeptide.ProteinDescription of a protein.Protein FamilyDesription of a set of related proteins.Published CitationRNA EditingDescription of any type of RNA editing that leads to one or more amino acid changes.1111A range of amino acids on a protein sequence.A rank of a taxon.Redox PotentialReports the value of the standard (midpoint) oxido-reduction potential(s) for electron transport proteins.RegionRepeatExtent of an internal sequence repetition.1A life science resource.true The class of all reviewed records in the database (i.e. records that where looked at by a curator for integration into the database).Ribosomal FrameshiftingSecondary StructureDescribes the secondary structure of proteins whose tertiary structure is known experimentally.An amino acid sequence.Sequence AnnotationDescription of a special region or site in a protein sequence.Sequence CautionWarning about possible errors related to the protein sequenceSequence ConflictDifferent sources report differing sequences.Unsure ResidueUsed to describe region(s) of a sequence for which the authors are unsure about the sequence assignment.Signal PeptideExtent of a signal sequence (prepeptide).SimilarityDescription of the similarities (sequence or structural) of a protein with other proteins.Simple SequenceSiteAny interesting single amino-acid site on the sequence, that is not defined by another feature key. It can also apply to an amino acid bond which is represented by the positions of the two flanking amino acids.Indicator for the reliability of a piece of information.StrainA strain of a species.Structure DeterminationAn experimental method for determining the 3D structure of a protein.Structure Mapping StatementThe relationship between a protein and a 3D structure.Structure Resource1A resource that describes the 3D structure of a protein.A resource that holds a set of the known names for this protein together.Subcellular LocationSubcellular LocationDescription of the subcellular location of the mature protein.Submission Citation1Data that was submitted directly to a database.SubunitDescription of the quaternary structure of a protein.1An element of a taxonomy for classifying life forms.Temperature DependenceIndicates the optimum temperature for enzyme activity and/or the variation of enzyme activity with temperature variation; the thermostability/thermolability of the enzyme is also mentioned when it is known.Thesis Citation1A Ph.D. thesis.TissueA tissue such as lung or heart.Tissue SpecificityDescription of the tissue specificity of a protein.Topological DomainA topological domain.TopologyToxic DoseInformation on the LD(50). LD stands for "Lethal Dose". LD(50) is the amount of a toxin, given all at once, which causes the death of 50% (one half) of a group of test animals.Transcribed RNATranscript ResourceTransit PeptideExtent of a transit peptide (mitochondrion, chloroplast, thylakoid, cyanelle or microbody).TransmembraneExtent of a transmembrane region.TransposonA transposonTurnTurns within the experimentally determined protein structure.Unassigned DNAUnassigned RNAUnknown SequenceUnpublished CitationViral cRNAPositive cRNA molecule that is made from from a single stranded genomic RNA.Zinc FingerExtent of a zinc finger region.Atmospheric Pressure IonizationMass measurement using Atmospheric Pressure IonizationApicoplastBy SimilarityChloroplastTaxonomy rank ClassCyanelleElectrospray IonizationElectron MicroscopyThe electron microscope is a microscope that can magnify very small details with high resolving power due to the use of electrons rather than light to scatter off material, magnifying at levels up to 500,000 times.Evidence at protein levelEvidence at transcript levelIndicates that the existence of a protein has not been strictly proven but that expression data (such as existence of cDNA(s), RT-PCR or Northern blots) indicate the existence of a transcript.Indicates that there is some experimental evidence that the given annotation could apply.Fast Atom BombardmentTaxonomy rank FamilyFiber DiffractionTaxonomy rank FormaTaxonomy rank GenusHydrogenosomeInferred from homologyTaxonomy rank InfraclassTaxonomy rank InfraorderInfrared SpectroscopyA type of spectroscopy that uses the Infrared portion of the electromagnetic spectrum.Taxonomy rank KingdomLiquid Secondary IonizationMatrix-Assisted Laser DesorptionMitochondionNMR SpectroscopyNeutron DiffractionNon-photosyntethic plastidNuleomorphTaxonomy rank OrderOrganellar chromatophorePlasma DesorptionTaxonomy rank ParvorderTaxonomy rank PhylumPlastidPotentialindicates that there is some logical or conclusive evidence that the given annotation could apply. This non-experimental qualifier is often used to present results from protein sequence analysis software tools, which are only annotated if the result makes sense in the biological context of a given protein. A typical example is the annotation of N-glycosylation sites in secreted proteinsPredictedThis is used for proteins without evidence at protein, transcript, or homology levels.PredictionProbableThe status ‘Probable’ indicates stronger evidence than the qualifier ‘Potential’. This qualifier implies that there must be at least some experimental evidence, which indicates, that the information is expected to be found in the natural environment of a protein.Surface Enhanced Laser Desorption IonizationTaxonomic rank SpeciesTaxonomic rank Species GroupTaxonomic rank Species SubgroupTaxonomic rank SubclassTaxonomic rank SubfamilyTaxonomic rank SubgenusTaxonomic rank SubkingdomTaxonomic rank SuborderTaxonomic rank SubphylumTaxonomic rank SubspeciesTaxonomic rank SubtribeTaxonomic rank SuperclassTaxonomic rank SuperfamilyTaxonomic rank SuperkingdomTaxonomic rank SuperorderTaxonomic rank SuperphylumTaxonomic rank TribeUncertainTaxonomic rank VarietasX-Ray CrystallographyA technique in crystallography in which the pattern produced by the diffraction of x-rays through the closely spaced lattice of atoms in a crystal is recorded and then analyzed to reveal the nature of that lattice.