@article {41,
title = {Further evidence for the likely completeness of the library of solved single domain protein structures},
journal = {J Phys Chem B},
volume = {116},
year = {2012},
month = {2012 Jun 14},
pages = {6654-64},
abstract = {Recent studies questioned whether the Protein Data Bank (PDB) contains all compact, single domain protein structures. Here, we show that all quasi-spherical, QS, random protein structures devoid of secondary structure are in the PDB and are excellent templates for all native PDB proteins up to 250 residues. Because QS templates have a similar global contour as native, TASSER can refine 98\% (90\%) of those whose TM-score is 0.4 (0.35) to structures greater than or equal to the 0.5 TM-score threshold (0.74 (0.64) mean TM-score) for CATH/SCOP assignment. On the basis of this and the fact that, at a TM-score of 0.4, 83\% (90\%) of all (internal) core secondary structure elements are recovered, a 0.40 TM-score is an appropriate fold similarity assignment threshold. Despite the claims of Taylor, Trovato, and Zhou that many of their structures lack a PDB counterpart, using fr-TM-align, at a 0.45 (0.5) TM-score threshold, essentially all (most) are found in the PDB. Thus, the conclusion that the PDB is likely complete is further supported.},
issn = {1520-5207},
doi = {10.1021/jp211052j},
attachments = {http://brylinski.cct.lsu.edu/sites/default/files/biblio/2012_jpcb.pdf},
author = {Skolnick, J and Zhou, H and Brylinski, M}
}