Incorporates allele-specific read counts in CNV detection and estimates accurate allele-specific copy number (ASCN) using either WGS or WES data. AS-GENSENG not only predicts ASCN calls but also improves the accuracy of total copy number calls, owing to its unique ability to exploit information from both total and allele-specific read counts while accounting for various experimental biases in sequence data.

AS-GENSENG statistics

To access cutting-edge analytics on consensus tools, life science contexts and associated fields, you will need to subscribe to our premium service.

AS-GENSENG in publication

[…] of magnitude faster than genseng across all window sizes; and, 2) when the window size is small (100bps) and the scale of the data is huge (25 million windows), the reduction in running time with as-genseng is remarkable (i.e., r-genseng uses 6 hours but genseng uses 60 hours). fig. 2 , next we evaluated the relative accuracy of r-genseng for cnv calling. we had evaluated previously […]

To access a full list of publications, you will need to upgrade to our premium service.

Department of Genetics, University of North Carolina at Chapel Hill, NC, USA

AS-GENSENG funding source(s)

The National Institutes of Health [K01MH093517 to J.P.S.; R01HG006292, R01CA082659 to W.S.; U01CA105417, U01CA134240, MH090338, HG006703 to W.W.; K01MH094406 to J.J.C.]; the National Science Foundation [IIS1313606 to W.W.].