The Denver Broncos scored more points than they ever had in their 54-year history on Sunday, blowing out the Eagles, 52-20, behind Manning’s four touchdown throws and two special teams scores.

‘‘Might have to give old Thunder an IV after this one,’’ Manning said of the white Arabian gelding who trots around the Sports Authority Field following touchdowns.

If there’s any IV bags left, that is.

With two TD passes each to Demaryius Thomas and Wes Welker, Manning completed all but a half-dozen of his 34 throws for 327 yards.

He didn’t even step on the field in the fourth quarter and cooled his cleats on the sideline for a 12-minute stretch in the first half, no less.

Just another day in the life of Manning, whose 16 TD passes are the most in the first month of a season, besting the previous mark of 14 set by Don Meredith in 1966 and tied by Kurt Warner in 1999.

Manning also joined Milt Plum in 1960 as the only quarterbacks to throw that many touchdown passes without an interception.

‘‘We have high expectations for ourselves and want to go out there and score a lot of points,’’ Welker said. ‘‘We were able to do that today.’’

Just as they have all season, piling up 49, 41, 37, and 52 points, thanks mostly to Manning, who helped Denver outgain Michael Vick and the Eagles 472 yards to 450.

Manning drove Denver (4-0) on a trio of long TD drives in the third quarter. Those drives covered 80, 80, and 65 yards and the Broncos didn’t face a third down in any of them.

The Eagles (1-3) also allowed two TDs on special teams in losing for the third straight time, all to AFC West opponents: Trindon Holliday’s 105-yard kickoff return and Steven Johnson’s blocked punt, which he scooped up himself and returned 17 yards.

Matt Prater’s 53-yard field goal capped Denver’s 15th straight regular-season win, which bested the franchise mark of 14 set in 1997-98 and also broke the previous franchise scoring record of 50 points set against San Diego on Oct. 6, 1963.

Only the 1966 Dallas Cowboys, with 183 points, scored more than the Broncos’ 179 in their first four games.