The aim of this pilot study is to examine (1) whether monitoring of daily experiences during and after tapering of antidepressants gives personalized insights in warning signals preceding transitions in depression (2) whether individuals find it helpful to monitor their daily experiences during and after tapering of depressive symptoms. Furthermore, the feasibility of this intensive diary study will be examined and the diary questions included in the study will be evaluated with participants. This is a pilot for the larger TRANS-ID tapering study.

Participants

Participants should meet all of the following criteria: – age ≥ 18 – a history of depressive symptoms – having made a shared decision with a mental health care provider to taper the current dose of antidepressant medication – having made a tapering scheme or plan with a mental health care provider

Study

The effect of Virtual Reality exposure Therapy (VRET) on social participation in people with a psychotic disorder: a multisite randomised controlled trial

First, to investigate the effect of Virtual Reality exposure therapy on social participation. Second, to investigate the longitudinal course of symptoms and social behaviour in psychosis on group and individual level.

This exploratory intervention study is set out to examine effects of tailor-made lifestyle advice, based on observed individual temporal patterns of lifestyle factors and experienced pleasure, as a non-pharmacological means to restore the pleasure of everyday activities and accomplishments. In addition, we will explore whether exposure to tandem skydiving, an experience known to activate the dopamine system and to elicit strong emotions, can help to reboot the reward system and hence foster the recommended lifestyle changes.

The objective of this study is to investigate the within-person dynamics of psychosocial stress levels and its effect on subsequent day-to-day fluctuations in blood pressure, heart rate, cortisol and melatonin levels in healthy volunteers for a period of 63 consecutive days by means of multivariate time-series analyses.

The proposed study aims to investigate whether (part of the) individuals who are at high risk to develop affective problems when faced with adversities also benefit more from positive environmental influences. Its main objective is to investigate how emotional reactivity to negative experiences and emotional reactivity to positive experiences are related in daily life and in the brain.

The primary aim of this study is to investigate the role of physical activity in the etiology of depressed mood, individual differences therein, and clues for tailor-made interventions. A second aim of this study is to elucidate the temporal relationship between mood symptoms and several stress-related hormones and enzymes, such as cortisol and alpha-amylase.

Investigating the bidirectional association between heart rate variability (HRV) and anxiety symptoms to get a better understanding of the individual etiology of patients with panic disorder combined with agoraphobia.