NFL Winners and Losers Week 5

What more can be said about Peyton Manning's assault on NFL defenses? The future Hall of Famer's latest victim was the Dallas Cowboys, against whom Manning threw for four touchdowns and ran for another in an epic 51-48 win. Manning is a huge Week 5 winner as Denver improves to 5-0.

It's hard to call Tony Romo a loser this week, as he threw for 506 yards and five touchdowns. However, he wasted that amazing effort by tossing a game-crushing interception with 1:57 remaining, which led to the game-winning field goal by the Broncos. How many times have we seen this?

In a matchup between last year's NFL Rookie of the Year runners-up, Andrew Luck and the Colts prevailed over Russell Wilson and the Seahawks. Luck engineered his ninth game-winning drive in beating the Seahawks, 34-28. Wilson had a better statistical game than Luck, but bottom line: The Colts' second-year QB made plays down the stretch and Wilson didn't.

Indy is a big winner for Week 5.

On the flip side, Richard Sherman and the Seattle defense looked very pedestrian against the Colts receivers. The Seahawks dropped to 4-1 on the season and are losers for Week 5.

Other mainstay losers include the 0-5 Giants, led by Eli Manning's three interceptions, and the Jaguars, who also dropped to 0-5.

For more winners and losers, check out the video above. Let us know who you thought were winners and losers for Week 5.