Conventional single-pulsed-field-gradient (s-PFG)
methodologies are capable of faithfully depicting
diffusion anisotropy in coherently ordered structures.
However, microstructure is more difficult to
characterize where macroscopic organization is absent.
Double-PFG (d-PFG) MR methodologies were recently
suggested as an alternative for studying microstructure
in such cases. The spinal cords white matter (WM) of
Long Evans shaker (les) rats, a dysmyelinated model, was
recently studied by q-space MRI. Here, we characterize
the spinal cords of les rats and their controls by d-PGSE,
focusing on the gray matter (GM), in comparison with
DTI. d-PFG clearly differentiates between three GM areas
of the les spinal cord.

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