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SUMMARY:New mechanistic insights into DNA repair by non-homologous end-joi
ning - Andrew Blackford (University of Cambridge)
DTSTART;VALUE=DATE-TIME:20150312T123000Z
DTEND;VALUE=DATE-TIME:20150312T133000Z
UID:https://talks.ox.ac.uk/talks/id/91c24d73-3eb9-4cbd-a74f-e1b365752aff/
DESCRIPTION:New mechanistic insights into DNA repair by non-homologous end
-joining\n\nDNA double-strand breaks are highly toxic DNA lesions that can
lead to cell death or genome instability and cancer if they are not repai
red in an error-free way. Most DNA double-strand breaks in human cells are
repaired by a process called non-homologous end-joining (NHEJ). This path
way involves initial processing and eventual re-ligation of the broken DNA
ends by a variety of different proteins and enzymatic activities in a tig
htly controlled manner. While NHEJ is required for maintenance of genome s
tability in all cells\, it plays a particularly important role in developi
ng lymphocytes\, because programmed DNA double-strand breaks are generated
at immune receptor loci to generate antibody diversity. During my talk\,
I will discuss our recent identification of PAXX\, a previously uncharacte
rised factor that plays a key role in DNA repair by NHEJ. I will describe
how\, using structural biology\, biochemistry and cell biology approaches\
, we have found that PAXX most likely acts as a molecular lock to hold tog
ether two broken DNA ends to promote repair of a double-strand break. The
implications this has for our current understanding of how cells repair DN
A by NHEJ will also be discussed.\n\nSpeakers:\nAndrew Blackford (Universi
ty of Cambridge)
LOCATION:MRC Weatherall Institute of Molecular Medicine (Seminar Room)\, H
eadington OX3 9DS
URL:https://talks.ox.ac.uk/talks/id/91c24d73-3eb9-4cbd-a74f-e1b365752aff/
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DESCRIPTION:Talk:New mechanistic insights into DNA repair by non-homologou
s end-joining - Andrew Blackford (University of Cambridge)
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