Trial Information

- Determine the incidence and etiologic significance of variants of known melanoma
susceptibility genes (MSGs) in families with multiple cases of melanoma.

- Determine the proportion of multiple-case families that are explained by
high-penetrance mutations in known MSGs.

- Determine the proportion of multiple-case families that are explained by these
mutations and whether it varies with latitude, as a surrogate for ultraviolet exposure,
with number of affected relatives, with average age at onset of melanoma in relatives,
with presence of multiple primary melanoma, or with other family-specific variables.

- Determine the penetrance of MSG mutations in these families.

- Determine if the penetrance varies with age, sex, or birth cohort.

- Determine if the penetrance varies with the gene involved or nature of the mutation.

- Assess the penetrance in mutations that also have a deleterious effect on the
alternative splice product, p14ARF.

- Determine whether carriers of MSGs have an increased susceptibility to other types of
cancer.

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