Collectively, our findings suggest that, due to the combined lipostatic, antiproliferative, and antiinflammatory effects, CBD has potential as a promising therapeutic agent for the treatment of acne vulgaris.

processes, including cutaneous cell growth and differentiation. Here, we
explored the effects of the major nonpsychotropic phytocannabinoid of
Cannabis sativa, (-)-cannabidiol (CBD), on human sebaceous gland
function and determined that CBD behaves as a highly effective
sebostatic agent. Administration of CBD to cultured human sebocytes and
human skin organ culture inhibited the lipogenic actions of various
compounds, including arachidonic acid and a combination of linoleic acid
and testosterone, and suppressed sebocyte proliferation via the
activation of transient receptor potential vanilloid-4 (TRPV4) ion
channels. Activation of TRPV4 interfered with the prolipogenic ERK1/2
MAPK pathway and resulted in the downregulation of nuclear receptor
interacting protein-1 (NRIP1), which influences glucose and lipid
metabolism, thereby inhibiting sebocyte lipogenesis. CBD also exerted
complex antiinflammatory actions that were coupled to A2a adenosine
receptor-dependent upregulation of tribbles homolog 3 (TRIB3) and
inhibition of the NF-κB signaling. Collectively, our findings suggest
that, due to the combined lipostatic, antiproliferative, and
antiinflammatory effects, CBD has potential as a promising therapeutic
agent for the treatment of acne vulgaris.

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