The overall goal of this quality improvement project is to develop and evaluate the effectiveness of a vaccination optimization program integrated into the out-patient clinical care delivery system for rheumatoid arthritis (RA) patients at a large, urban, tertiary‐care medical center. The program will be developed and tested to operate in multiple domains to synergize the effects of provider based education; a disease specific electronic medical record (EMR) based information technology (IT) alert system, and support staff tracking and surveillance with the intent to increase vaccination rates within this vulnerable population.