Title

Inventor

Document Type

Patent Number

Patent agency

Publication Date

12-28-1976

Assignee

University of Iowa Research Foundation (Iowa City, IA, US)

Application Number

381,466

Date Filed

1973-07-23

Total Pages

8 pages

Abstract

The synthesis of enantiomers of a series of methoxy- and alkyl- substituted phenylisopropylamines is described. The synthesis comprises reducing the imines, formed by the reaction of appropriate phenylacetones with either (+)- or (-)-α-methylbenzylamine, by low-pressure reduction techniques, and subsequently subjecting the optically active N-(α-phenethyl)phenylisopropylamine derivative to hydrogenolysis. The hydrogenolysis products are characterized by enantiomeric purities in the range of 96 - 99%. Yields of products are approximately 60%.