Season 5* Episode 1: Dying Changes EverythingOriginal Air Date—16 September 2008
House's preoccupation with Wilson leaves his team without direction and endangers the patient* a female whose exhaustive work schedule and demanding boss may have caused her condition.

Season 5* Episode 2: Not CancerOriginal Air Date—23 September 2008
Years after receiving body parts from an organ donor* five out of six recipients die within a few months* but not from organ rejection. House and the team race against time to figure out why before the final surviving recipient* a young woman who received the donor's cornea* mysteriously dies as well. House retains a comical private investigator to investigate patients* doctors* and his estranged friend* Wilson.

Season 5* Episode 4: BirthmarksHouse tries every delaying tactic available when Wilson forces him to attend his father's funeral. Meanwhile* the team tries to find the cause of a young woman's abdominal pain and hemorrhage that occurred in China.

Season 5* Episode 5: Lucky ThirteenOriginal Air Date—21 October 2008
Thirteen's one night stand collapses at her apartment* and her symptoms are so misleading that the diagnosis may be terminal. Meanwhile* revelation about Wilson and Thirteen occupy House.

Season 5* Episode 6: JoyOriginal Air Date—28 October 2008
House takes on a case where the patient has unexplained blackouts* and his daughter may hold the key to the diagnosis. Meanwhile* Cuddy prepares for her new arrival until there are complications with the birth mother.

Season 5* Episode 9: Last ResortOriginal Air Date—25 November 2008A person takes House* Thirteen and others as hostages. He's seen several doctors but none have found what ails him. As they work towards finding a solution* Thirteen makes decisions which leads her to think about her own condition.

Season 5* Episode 10: Let Them Eat CakeOriginal Air Date—2 December 2008The drug trial brings back memories for Thirteen; Kutner and Taub scramble as they try to salvage a scam and save the team's patient whose gastric bypass may not have saved her life.

Season 5* Episode 11: Joy to the WorldOriginal Air Date—9 December 2008A obese teenager collapses on stage. The outcome will lead to a surprise for Cuddy. Wilson convinces House to be nice to his patients during the holidays. Foreman and Thirteen have issues when a trial patient drops from the program.

Season 5* Episode 12: PainlessOriginal Air Date—19 January 2009House treats a patient who's worn out by chronic pain. Cuddy tries to do her job and take care of her new child. Foreman and Thirteen's relationship stalls.

Season 5* Episode 13: Big BabyOriginal Air Date—26 January 2009House maneuvers against a measured Cameron when she takes over Cuddy's duties, Foreman faces an ethical dilemma, and Cuddy has trouble bonding with the baby.

Season 5* Episode 14: The Greater GoodOriginal Air Date—2 February 2009A physician who gave up her career comes in for treatment, leading to tense encounters with the team. Meanwhile, Cuddy exacts revenge and Foreman's choice has devastating consequences.

Season 5* Episode 15: UnfaithfulOriginal Air Date—16 February 2009House treats a priest who's lost his faith, issues an ultimatum to Foreman and Thirteen, and plays with Cuddy's desire to have him attend - or is it not attend? - her baby's naming ceremony.

Season 5* Episode 16: The Softer SideOriginal Air Date—23 February 2009House's team resents being made complicit in a web of lies parents have told their son when he's brought in for treatment that may be related to his intersexuality. Meanwhile, no one's content that House is happy.

Season 5* Episode 17: The Social ContractOriginal Air Date—9 March 2009The team tries to diagnose a condition that leaves the patient saying anything that he thinks, no matter whom it hurts, and Wilson raises House's antennae when he passes up a monster truck rally.

Season 5* Episode 18: Here KittyOriginal Air Date—16 March 2009House treats a patient who is convinced she's dying because of cat. Meanwhile Taub catches up with an old High School classmate and contemplates leaving the team.

Season 5* Episode 19: Locked InOriginal Air Date—30 March 2009House is injured in a motorcycle accident. While recovering, he finds an accident victim suffering from a brain injury. House tries to prove the brain damage caused the accident, not vice versa, so he can treat the patient.

Season 5* Episode 20: Simple ExplanationOriginal Air Date—6 April 2009Taub treats a patient whose dying husband gets better as she becomes sicker, while the rest of the team deals with a devastating loss.

Season 5* Episode 21: SaviorsOriginal Air Date—13 April 2009House worries he's lost his mojo when he can't determine the reason for Cameron and Wilson's changed behaviors or his new patient's diagnosis.

Season 5* Episode 22: House DividedOriginal Air Date—27 April 2009House's Amber hallucination becomes more aggressive as sleep deprivation takes its toll endangering a patient, and Chase's bachelor party ends in the emergency room.

Season 5* Episode 23: Under My SkinOriginal Air Date—4 May 2009When all of House's efforts to rid himself of Amber fail, he turns to someone unexpected for assistance. Meanwhile, the team is left to fend for itself as they try to save a ballerina's life and career.

Season 5* Episode 24: Both Sides NowOriginal Air Date—11 May 2009House and his team treat a patient who had his brain split in half, now it seems like one side of his brain is causing some health/behavioral issues. House plays games with Cuddy over the night he detoxed, and those events will cause major changes. Cameron and Chase come to a decision.