This is a research line aiming to the discovery of actionable mechanism to improve the prevention
and eradication of inhibitors. The main laboratory for this line is located at the Department of Pharmacology of the University of Perugia (prof Paolo
Puccetti, prof Francesca Fallarino, Dr Davide Matino). The research line involves both in vitro, in vivo and ex-vivo experiments, and is supported by
several centers of the Associazione Italiana Centri Emofilia. The research has been supported by unrestricted peer review funds from the Bayer Award
Program (Davide Matino and Francesca Fallarino), Italina Ministry of Health (Davide Matino), Telethon (Francesca Fallarino).

This is an exciting innovative project where the McGrade working group, led by Holger Schunemann,
is supporting the development of guidelines for the management of hemophilia fostered by the National Hemophilia Foundation.