But by what I have gathered from your own relation, and the answers I have with much pains wrung and extorted from you, I cannot but conclude the bulk of your natives to be the most pernicious race of little odious vermin that nature ever suffered to crawl upon the surface of the earth.

There are no more uses of "pernicious" in the book.

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By the 21st century, it had evolved into a pernicious lack of employment.