Histone lysine methylation is considered to be a relatively stable modification associated with important functions in epigenetic gene control and for organizing chromatin domains. Genes encoding mammalian homologues of ...

Ovarian carcinoma (OC), primary peritoneal carcinoma (PPC) and malignant mesothelioma (MM) are all highly aggressive tumors that share common morphological features in addition to being histogenetically related. It is of ...

Crucian carp, Carassius carassius, survives days to months without oxygen (anoxia). Still, during anoxia, it needs to keep the energy expenditure low, particularly in the brain, which has a high rate of ATP use mainly ...

Background
Despite the fact that metastases are the leading cause of colorectal cancer deaths, little is known about the underlying molecular changes in these advanced disease stages. Few have studied the ...

Background
Multiple epigenetic and genetic changes have been reported in colorectal tumors, but few of these have clinical impact. This study aims to pinpoint epigenetic markers that can discriminate between ...

Absolute tumor DNA copy numbers can currently be achieved only on a single gene basis by using fluorescence in situ hybridization (FISH). We present GeneCount, a method for genome-wide calculation of absolute copy numbers ...

Background
In many cell types, including the fission yeast Schizosaccharomyces pombe, a set of checkpoints are induced by perturbations of the cell cycle or by DNA damage. Many of the checkpoint responses ...

Abstract
Glutamate is the major excitatory neurotransmitter in the mammalian central nervous system
(CNS), and is inactivated by cellular uptake, mostly catalyzed by glutamate (excitatory amino
acid) transporter subtype ...

Bacillus cereus ATCC 14579 was grown under different conditions, in different growth media, and the following parameters were investigated; cell number, pH,oxygen levels, glucose levels, cell morphology, proportions of ...

Transmissible spongiform encephalopathies (TSEs) are fatal, neurodegenerative diseases in human and animals, caused by prion protein (PrP). The functions of PrP and the basis of these diseases are still under debate. In ...

The Fe(II)- and 2-oxoglutarate (2OG)-dependent dioxygenase AlkB from E. coli is a demethylase which repairs alkyl lesions in DNA, as well as RNA, through a direct reversal mechanism. Humans possess nine AlkB homologs ...

Multiple DNA damaging agents cause deaminations of the bases of DNA. If not repaired, these can lead to mutations, which in turn can result in dangerous diseases. Endonuclease V (EndoV) is a highly conserved gene from ...