Islamabad: A US drone targeted a house in Pakistan's lawless North Waziristan tribal region on Wednesday, killing four persons in the first missile strike since the country's landmark general election on May 11.

The CIA-operated spy plane targeted a house in Chashma Pul area of Miranshah, the main town of North Waziristan Agency.

Four persons in the house were killed instantly and two others injured. Local residents said several drones were seen hovering over the area after the attack.

The injured were taken to a nearby hospital, where officials described their condition as critical. The identity of the dead and injured could not immediately be ascertained.

This was the first drone strike in Pakistan since the May 11 polls and the announcement of a new policy for the use of the spy planes by President Barack Obama.