Both $^{45}Ca^{2+}$ Uptake and $^{45}Ca^{2+}$ Release were Decreased in the Junctional Sarcoplasmic Reticulum Vesicles of Diabetic Heart

Abstract

Abnormally high Ca2+ concentrations have been reported in the cardiac myocytes of diabetic mellitus (DM). In order to elucidate the molecular mechanisms of the intracellular Ca2+ overload, the activities of 45 Ca2+ uptake and 45 Ca2+ release were measured from the vesicles of junctional SR (Heavy SR, HSR). (omitted)omitted)

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