Before life existed on Earth, there was just matter, inorganic dead "stuff." How improbable is it that life arose? And — could it use a different type of chemistry? Using an elegant definition of life (anything that can evolve), chemist Lee Cronin is exploring this question by attempting to create a fully inorganic cell using a "Lego kit" of inorganic molecules — no carbon — that can assemble, replicate and compete.