Patent pending Integrated Thermal Control (ITC) forms the basis
of this system. It has long been recognised that intra-sample
variations caused by thermal gradients within metal block or
air-heating systems causes differences in the final product
(quantity and quality).

ITC uses the concept of directly heating the vessel containing
the reaction mix and in addition having a single temperature
sensor for each vessel to ensure truly independent thermal control.
Direct heating also has a significant effect on thermal transfer
rates as does the ‘capillary’ design of the reaction
vessel (allows for a high surface to volume ratio) both leading
to
ULTRA-RAPID Thermal Cycling.

High
throughput, cleaner reaction products and the ability to run
reactions with different thermal profiles are significant advantages
of this technology e.g. running gradients for process optimisation,
multiple different tests on the same sample in diagnostic applications
where time to report results is critical and high throughput
screening.