NISCAIR Online Periodicals Repository Community: IJBB Vol.45 [2008]http://nopr.niscair.res.in/handle/123456789/356
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Book Reviewhttp://nopr.niscair.res.in/handle/123456789/3132
Title: Book Review
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<br/>Authors: Mohanty, Prasanna
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<br/>Abstract: Advances in Photosynthesis and Respiration
(AIPH) (Series Editor: Govindjee, University of
Illinois, USA). Volume 26: “Biophysical
Techniques in Photosynthesis II (Edited by Thijs J
Aarsma and Jörg Matysik); Published by Springer,
The Netherlands, 2008. ISBN: 976-1-4020-8249-8
(hardcover), 520 pages, & colour plates.
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<br/>Page(s): 354-355Sun, 28 Sep 2008 22:58:59 GMTPolaron hopping in some biomolecular solids and their charge transfer complexeshttp://nopr.niscair.res.in/handle/123456789/2711
Title: Polaron hopping in some biomolecular solids and their charge transfer complexes
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<br/>Authors: Solanki, G K; Amin, Anand; Padhiyar, Ashvin; Ray, A K; Oza, A T
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<br/>Abstract: The solid state spectroscopy of charge transfer complexes of biomolecules such as fatty acids, tripalmitin, lysozyme. folic acid, β-carotene, cytochrome c, valinomycin and gramicidin has been carried out. The absorption coefficient is related with electronic conductivity. A half-power beta density is found common among these macromolecular solids, indicating photon-induced polaron hopping or hopping of a charge carrier between two branches of a polariton. Band gap vs full width at half-maximum of the mid-IR peak also reveals a linear relation.
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<br/>Page(s): 421-429Fri, 28 Nov 2008 22:58:59 GMTSemi-empirical calculations on paullones, a promising class of cyclin-dependent kinase inhibitorshttp://nopr.niscair.res.in/handle/123456789/2710
Title: Semi-empirical calculations on paullones, a promising class of cyclin-dependent kinase inhibitors
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<br/>Authors: Sharma, Pooja Sapra; Tyagi, Reena; Sharma, Rajan
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<br/>Abstract: Paullones, a group of ATP-competitive 7,12-dihydroindolo [3,2-d][1]benzazepin-6(5H)-ones are well-established cyclin-dependent kinase (CDK) inhibitors with promising anti-tumoral properties. In this study, AM1 (Austin model 1) calculations have been performed on paullones and their biological activities have been explained with respect to their HOMO and LUMO energies. 9-Substituted paullones with electrophilic character show high potencies. The interaction of 9th substitutent with Phe-80 of receptor plays a key role in binding and potency. The study will help medicinal chemists to design efficient CDK inhibitiors.
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<br/>Page(s): 416-420Fri, 28 Nov 2008 22:58:59 GMTDietary cholesterol and estrogen administration elevate brain apolipoprotein E in mice by different mechanismshttp://nopr.niscair.res.in/handle/123456789/2709
Title: Dietary cholesterol and estrogen administration elevate brain apolipoprotein E in mice by different mechanisms
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<br/>Authors: Srivastava, Neelam; Averna, Maurizio; Srivastava, Rai Ajit K
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<br/>Abstract: Apolipoprotein (apo) E plays an important role in the whole body cholesterol homeostasis. Recent studies suggest that it may also be involved in the local cholesterol transport in the brain, and influence the pathogenesis of Alzheimer’s disease (AD) by interacting with the β-amyloid protein and brain lipoprotein receptors. Since apoE expression is highest in the brain, next only to the liver and associated with the pathogenesis of AD, we hypothesized that dietary and hormonal intervention, known to regulate hepatic apoE expression may also regulate brain apoE and thereby influence local cholesterol transport. To test this hypothesis, groups of male C57BL mice were fed either regular rodent chow or high fat (HF) and high cholesterol enriched diet for 3 weeks. In a separate study, groups of male mice were administered pharmacological doses of 17-β estradiol for 5 consecutive days and sacrificed on the 6th day. As expected, HF diet elevated liver apoE mRNA and apoE synthesis. Similar to liver, brain apoE mRNA and synthesis also increased, following HF feeding. Estradiol administration increased liver apoE synthesis without affecting apoE mRNA. Interestingly, estradiol administration also increased the brain apoE synthesis, but without altering the brain apoE mRNA. These studies suggested that dietary cholesterol and estrogen administration elevated the brain apoE by different mechanisms.
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<br/>Page(s): 410-415Fri, 28 Nov 2008 22:58:59 GMT