What do we know so far? Review published!

The discussion about diseases of unknown etiology, among others Kawasaki disease, arises multiple questions: Can environmental factors, such as air-transported preformed toxins, be of key relevance to the health outcomes of poorly understood human ailments (e.g., rheumatic diseases such as vasculitides, some inflammatory diseases, or even severe childhood acquired heart diseases)? Can the physical, chemical and biological features of air masses be linked to the emergence of diseases such as Kawasaki disease (KD), Henoch–Schönlein purpura, Takayasu’s aortitis, and ANCA-associated vasculitis? Furthermore, would it be possible to develop early-warning systems based on environmental alerts and to implement these alarms to inform predisposed patients?

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