..This review briefly outlines some of these developments as applied to a number of selected natural product examples, which may also include advances in chemical synthesis of derivatives with extended biological activities. ..

..The "hot" terrestrial plant families Myrsinaceae and Sapindaceae have not been studied to any extent and appear to merit special attention, although leukemia cell line selectivity is also noted for other families...

Induced production of N-formyl alkaloids from Aspergillus fumigatus by co-culture with Streptomyces peucetius

..Cytotoxic activity of all the analogues was tested on the NCI-60 cell line screen, and compound 2 exhibited significant activity against several cell lines. The analogues did not show antimicrobial activity...

Marine-sourced anti-cancer and cancer pain control agents in clinical and late preclinical development

..The simple prime argument in support of this is the fact that we can exploit over four billion years of evolution in combinatorial chemistry in marine organisms, directed at relevant and effective biological activity...

A tale of two tumor targets: topoisomerase I and tubulin. The Wall and Wani contribution to cancer chemotherapy

..Additionally, new cloning and biosynthetic expression strategies may provide a sustainable method for the supply of new pharmaceuticals derived from the uncultured phytosymbionts of marine organisms...

..Examples of the application of combinatorial methods to nature's combinatorial library will be presented and discussed, with an emphasis on the antitumor, anti-infective and pain control disease areas...

..In addition, paclitaxel, and perhaps other taxanes in due course, has activities beyond the known antitumor indications, with an example being the use of paclitaxel-coated stents in cardiovascular therapies...

Cytotoxic xanthones from Psorospermum molluscum from the Madagascar rain forest