M MorrisSchool of Surgery and Pathology, University of Western Australia, Nedlands, AustraliaBr J Cancer 96:701-7. 2007

..Further prospective studies are required to identify better the physiological and socioeconomic factors responsible for failure to complete chemotherapy so that appropriate improvements in health service delivery can be made...

Genetic factors associated with intestinal metaplasia in a high risk Singapore-Chinese population: a cohort study

Feng ZhuDepartment of Medicine, National University of Singapore, Singapore, SingaporeBMC Gastroenterol 9:76. 2009

..A total of 18 polymorphisms in 14 candidate genes were evaluated in a Singapore-Chinese population at high risk of developing GC...

Comprehensive profiling of DNA methylation in colorectal cancer reveals subgroups with distinct clinicopathological and molecular features

..In the present study we performed comprehensive DNA methylation profiling of CRC with the aim of characterizing CIMP subgroups...

APC gene methylation is inversely correlated with features of the CpG island methylator phenotype in colorectal cancer

Barry IacopettaSchool of Surgery and Pathology, University of Western Australia, Nedlands, AustraliaInt J Cancer 119:2272-8. 2006

..003) and with lower concentrations of methyl group carriers (p < 0.05). These findings highlight the importance of gene selection in studies that aim to characterize the biological features and clinical behaviour of CIMP+ tumours...

..Further studies on tumors from randomized clinical trials are required to confirm the value of CIMP+ and associated molecular features for the prediction of clinical outcome to 5-FU-based chemotherapy...

The MTHFR C677T and DeltaDNMT3B C-149T polymorphisms confer different risks for right- and left-sided colorectal cancer

..Further investigation of genomic and CpG island methylation in normal colonic mucosa and the possible influences of environmental and genetic factors may provide new insights into the development of CIMP+ colorectal cancer...

..Finally, the MSI status of CRC is an extremely useful marker for population-based screening programs that aim to identify individuals and families with the hereditary cancer condition known as Lynch syndrome...

Shao Ying LiSchool of Surgery and Pathology, University of Western Australia, NedlandsOncol Rep 15:221-5. 2006

..Our results show that polymorphisms in two genes involved in methyl group metabolism are associated with hormone receptor content and DNA methylation frequency in breast cancer, however these observations are unlikely to be linked...

Melinda MorrisSchool of Surgery and Pathology, University of Western Australia, Nedlands, Western Australia, AustraliaClin Cancer Res 14:1413-7. 2008

..The aim of the present study was to investigate the prognostic significance of TILs and other routinely reported pathologic features in colon cancer, particularly in relation to the use of adjuvant chemotherapy...

BRAF mutation is associated with the CpG island methylator phenotype in colorectal cancer from young patients

Paul SalamaSchool of Surgery and Biostatistics Unit, Cancer Trials, Western Australian Institute for Medical Research, University of Western Australia, AustraliaJ Clin Oncol 27:186-92. 2009

..To determine the prognostic significance of FOXP3(+) lymphocyte (Treg) density in colorectal cancer compared with conventional histopathologic features and with CD8(+) and CD45RO(+) lymphocyte densities...

Population-based detection of Lynch syndrome in young colorectal cancer patients using microsatellite instability as the initial test

..The two cohorts were randomly pair-matched for age, sex, and tumor site, and the median length of follow-up time was 39 months...

Population-based screening for Lynch syndrome in Western Australia

Lyn SchofieldSchool of Surgery, University of Western Australia, Crawley, WA Genetic Services of Western Australia, King Edward Memorial Hospital, Subiaco, WA School of Paediatrics and Child Health, University of Western Australia, Crawley, WAInt J Cancer 135:1085-91. 2014

..Finally, a state or regional LS coordinator is essential to ensure that all appropriate cases identified by laboratory testing are referred to and attend a Familial Cancer Clinic for follow-up and germline testing. ..

Survival rates for stage II colon cancer patients treated with or without chemotherapy in a population-based setting

..The aim of the present study is to compare the survival rate of stage II colon cancer patients treated by surgery alone with that of patients also treated by chemotherapy...

Low expression of Granzyme B in colorectal cancer is associated with signs of early metastastic invasion

Paul SalamaSchool of Surgery, University of Western Australia, Nedlands, AustraliaHistopathology 59:207-15. 2011

..Because there is evidence that some tumour-infiltrating CD8+ T cells may be inactive, the present study aimed to investigate the prognostic significance of Granzyme B, one of the major effector molecules of T cells...

..About 12% of sporadic colorectal cancers also show MMR loss and MSI. The aims of this study were to evaluate MMR loss and MSI in relation to patient age, sex, tumor stage, and site in the large bowel...

Lack of association between CCND1 G870A polymorphism and the risk of breast and colorectal cancers

..The aim of this case-control study was to investigate whether the common G870A polymorphism in the Cyclin D1 gene (CCND1) is a risk factor for breast and colorectal cancers in an Australian population...

Comparing survival outcomes for patients with colorectal cancer treated in public and private hospitals

Melinda MorrisSchool of Surgery and Pathology, University of Western Australia, Perth, WAMed J Aust 186:296-300. 2007

..To determine whether treatment in a private versus public hospital was an independent predictor of survival outcomes in patients with colorectal cancer...

..Functional genetic variants in the methylene tetrahydrofolate reductase (MTHFR) and thymidylate synthase (TS) genes may be risk factors for breast cancer because of their central roles in cellular folate metabolism...

Incidence of BRAF p.Val600Glu and p.Val600Lys mutations in a consecutive series of 183 metastatic melanoma patients from a high incidence region

..Val600Glu (V600E) hotspot mutation in exon 15. The aim of the present study was to investigate the frequency of the less common p.Val600Lys (V600K) mutation in metastatic melanoma from a high incidence region...

A population-based study of age-related variation in clinicopathological features, molecular. Markers and outcome from colorectal cancer

Melinda MorrisSchool of Surgery and Pathology, University of Western Australia, Nedlands 6009, Western AustraliaAnticancer Res 27:2833-8. 2007

..To investigate age-related differences in clinicopathological features, molecular alterations and patient survival in a large, population-based series of CRC...

Development of a rapid genotyping method for single nucleotide polymorphisms and its application in cancer studies