BRCA EXCHANGE AND INFORMATION SHARING

The BRCA Exchange is a web portal to share expert-reviewed BRCA variant classifications

Is supported by the top experts in the field

Links the key variant databases

Provides expert validation of variant classification

The BRCA Exchange aims to advance our understanding of the genetic basis of breast cancer, ovarian cancer and other diseases by pooling data on BRCA1/2 genetic variants and corresponding clinical data from around the world [2]

Sharing variants in this manner allows variants of uncertain significance (VUS) to be efficiently reclassified: as either more likely to be pathogenic or non-pathogenic. Over time this should lead to lower VUS rates, allowing for more accurate interpretation of BRCA mutations [4]

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