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1.2 Motility stimulants

Please note: Metoclopramide and domperidone are not licensed for the treatment of gut motility problems including managment of oesophageal reflux, gastroparesis and in some patients with non-ulcer dyspepsia. Benefit no longer outweighs risk. Please see the link to safety information below.

Due to the risk of neurological adverse effects metoclopramide should only be prescribed for short term use (up to 5 days) and the maximum dose in 24 hours is 30mg (or 0.5mg/kg body weight). For more information see Drug Safety Update, August 2013

Domperidone may increase the risk of serious ventricular arrhythmias. For more information seeSection 4.6.

Prescribing notes

Motility stimulants were used in the management of oesophageal reflux, gastroparesis, nausea and in some patients with non-ulcer dyspepsia.

On this website you will now see four icons for these resources rather than two. Please use BNF Legacy or BNF for Children Legacy as these will take you to the original format of the online publications which do not have any errors or omissions.