interference with the homo-oligomer formation of Smad4 protein and the hetero-oligomer formation between SMAD4 and Smad2 proteins, resulting in disruption of TGFbeta signaling.

ovarian mucinous adenocarcinoma

Loss of Dpc4 (SMAD4) expression provides the most useful immunohistochemical evidence for establishing the pancreaticobiliary tract as the most likely source of these metastatic mucinous carcinomas in the ovary. (21263249)