In 2006, Berthiaume left ESPN to become chief sportscaster for the new SNY network started by the New York Mets; however, in late January 2007, SNY let Berthiaume out of his contract to rejoin ESPN's SportsCenter on March 28, 2007, in order to work closer to his wife.[1] He also anchored many (usually weekend) editions of Baseball Tonight.

In 2012, Berthiaume was hired by MLB's Arizona Diamondbacks to serve as a play-by-play broadcaster for FOX Sports Arizona, replacing Daron Sutton, and was quoted as saying, "The opportunity to be at the ballpark every day is a dream come true. I'm thrilled." Berthiaume's previous play-by-play experience comes from ESPN, where he called several professional games as well as the College World Series.[2]