St. Isaac of Syria Skete is a monastic community for men located in Boscobel, Wisconsin. There are currently four monks and one novice within the monastery.

The community was founded in April 1987 with the arrival of Abbot Simeon Gitlis to the Boscobel area. The skete is an offshoot of Christ of the Hills Monastery (COTH) in Blanco, Texas, which at the time belonged to the Archdiocese of Vasiloupolis.