which may affect the therapeutic response (see PRECAUTIONS – Drug Interactions).
Respiratory depression should be treated as an overdose.
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Doxazosin may increase the seizure risk in patients taking other medications that lower the seizure threshold.
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Forty patients were treated with either Doxazosin suppositories 100 mg 6 hourly.
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alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Doxazosin ; it may add to their effects.
1 Dosing may be increased to 100 mg every four to six hours, but the daily dosage should not exceed 400 mg 1 and should be limited to 250 to 300 mg .
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Doxazosin is a centrally acting synthetic opioid analgesic.
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Ask your pharmacist if you have questions about which medicines may cause drowsiness.Doxazosin may cause dizziness; alcohol, hot weather, exercise, or fever may increase this effect.
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Doxazosin is well absorbed orally with an absolute bioavailability of 75%. Doxazosin has a volume of distribution of approximately 2.7 L/kg and is only 20% bound to plasma proteins.
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This may not be a complete list of all interactions that may occur. Ask your health care provider if Doxazosin may interact with other medicines that you take.
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If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Doxazosin while you are pregnant.
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Doxazosin has a volume of distribution of approximately 2.7 L/kg and is only 20% bound to plasma proteins.

These mechanisms may contribute independently to the overall analgesic profile of Doxazosin.
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adjustment of the dosing regimen is recommended (see DOSAGE AND ADMINISTRATION).
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No effects on fertility were observed for Doxazosin at oral dose levels up to 50 mg/kg,
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