Abstract:This Small Business Innovation Research Phase I research project will develop an automated framework for knowledge acquisition. This automated framework will be based on the Principal Investigator's Rhem Knowledge Acquisition Framework and the Unified Modeling Language (UML). This automated… more

Abstract:The objective of this proposal is to construct and demonstrate the feasibility and efficacy of a proposed inexpensive, low power NonDestructive Evaluation (NDE) eddy current system for determining the extent of fatigue damage in multi-layer/tapered aircraft materials. The proposed NDE eddy current… more

Abstract:There is a requirement for compact low-cost active sensors for aided target identification in UAV operations. The mid-infrared (3-5 ¿m) is currently an unexploited spectral region because of the lack of frequency agile sources with narrow linewidths and high bandwidth detectors, which would be… more

Abstract:DESCRIPTION (provided by applicant): The goal of this project is to investigate the technical feasibility and commercial potential of a platform (PhenoNet) for custom phenotypic data repositories that encourages adoption of phenotypic data standards and exchange of knowledge across sources.… more

Abstract:The proposed Phase II study is directed at development of a run-flat tire for military vehicles using a patented tire manufacturing technology from MASYS (Israel) (US Patent #6,032,710 - 2000). This concept of the run-flat tire consists of a unique tread design supported with a spiral spring… more

Abstract:Phytosterols and lycopene are neutraceuticals that are known antioxidants and cancer inhibitors. Unfortunately, they do not dissolve readily in body fluids and therefore present unique problems concerning their uptake by the blood stream. This project explores the ability to enhance the rate of… more

Abstract:DESCRIPTION (provided by applicant): This Phase I SBIR proposal is the first step in the development of inhalable IgG microparticles for immunoprophylaxis against Influenza A, a category C Priority Pathogen. In Phase I, Aktiv-Dry will simultaneously stabilize, dry, and micronize IgG antibody… more

Abstract:72984-Currently available methods impose limits on the processing of multi-filamentary, superconducting wires used in high energy physics experiments. These limits can be severe when one of the wire components has a mechanical strength substantially smaller than the other component(s), and can… more

Abstract:72984-Currently available methods impose limits on the processing of multi-filamentary, superconducting wires used in high energy physics experiments. These limits can be severe when one of the wire components has a mechanical strength substantially smaller than the other component(s), and can… more

Abstract:Alaska Native Technologies, LLC (ANT) proposes to develop a hull-mounted sonar system that would be integrated into the DD(X) HF Mine Avoidance Bow Sonar processing chain to provide search and identification of small objects in the water column ¿60¿ swaths in front of the vessel. The proposed… more

Abstract:75239-Landfills are the single largest source of anthropogenic methane emissions in the United States, producing 7 million tons or 34% of the total methane pollution. According to the Intergovernmental Panel on Climate Control¿s Third Assessment Report, methane has a Global Warming Potential 23… more

Abstract:This Small Business Technology Transfer Phase II project will build on the great successes of the Phase I program by proving that the nanocoating of fine ferromagnetic particles is possible on the large scale and that such nanocomposite particles have commercial uses. The Phase I program proved that… more

Abstract:Humanized antibodies currently are produced through mammalian cell culture methods that require extensive resources, in particular, choosing the manufacturing cell line and the need for highly specialized cell growth facilities. These limitations have highlighted the need for new and more… more

Abstract:DESCRIPTION (provided by applicant): Current treatment of cancer patients relies on establishing an accurate diagnosis using a complex combination of clinical and histopathological data but in some instances accurate diagnosis is difficult or impossible because of atypical clinical or… more

Abstract:DESCRIPTION (provided by applicant): Despite our progress in combating infectious diseases during the last century, many of those diseases still represent major threats. Moreover, we now have the technical capability to render those diseases even more dangerous, and the potential for biological… more

Abstract:DESCRIPTION (provided by applicant): Despite our progress in combating infectious diseases during the last century, many of those diseases still represent major threats. Moreover, we now have the technical capability to render those diseases even more dangerous, and the potential for biological… more

Abstract:DESCRIPTION (provided by applicant): The CDC states that lead poisoning is the number one environmental health problem, affecting children in the US because it affects one of every six at-risk children and it is acknowledged to be a source of cognitive and behavioral impairment. Only 25% of the… more

Abstract:DESCRIPTION (provided by applicant):
Breast carcinoma is the leading cause of cancer in women in the U.S. It is well known that if breast cancer is detected when the tumor is small and axillary nodes are not involved, the survival rate is very high. However, if the cancer has spread with time, the… more

Abstract:72199-Proton Emission Tomography (PET) is a powerful imaging tool that can provide diagnosis for symptoms of diseases such as Alzheimer¿s, cancer, head trauma, and stroke. The performance of current clinical PET systems is limited by available detector technology. An urgent need exists to improve… more

Abstract:72619-Gamma ray spectrometers are an important element of nuclear and elementary particle physics experiments. However, the performance of the detection systems used in these experiments is often limited by the properties of presently available detectors. This project will investigate a new design… more

Abstract:72085-Proton Emission Technology (PET) is a powerful imaging tool that can provide diagnosis for symptoms of diseases such as Alzheimer¿s, cancer, head trauma, and stroke. However, the performance of current clinical PET systems is limited by available detector technology, and improved PET… more

Abstract:72157-Germanium strip detectors are very promising for X-ray and g-ray imaging with high resolution. However, existing n+ lithium electrodes prevent the full potential of high purity germanium (HPGe) strip detectors from being exploited in nuclear physics experiments as well as in many other… more

Abstract:72486-With the ever increasing number of smaller animals, such as mice and rats, being used as human disease models, the demand for small animal imaging also has increased. In particular, the pharmaceutical industry requires the in vivo quantification of biological processes, to measure the… more

Abstract:DESCRIPTION (provided by applicant):
Positron Emission Tomography (PET) is a nuclear imaging technology that makes use of a range of positron-labeled tracers to provide images that reflect different parameters relevant to tumor biology. Recent developments in PET technology are leading towards… more

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