Fusion

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Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:query proteins and first shell of interactors

white nodes:second shell of interactors

Node Content

empty nodes:proteins of unknown 3D structure

filled nodes:some 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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Gene Fusion

Cooccurence

Coexpression

Experiments

Databases

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[Homology]

Score

pcn

Proliferating cell nuclear antigen; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication (247 aa)

Predicted Functional Partners:

C497_17517

Nucleic acid binding OB-fold tRNA/helicase-type (309 aa)

0.998

C497_13251

Nucleic acid binding OB-fold tRNA/helicase-type (422 aa)

0.997

C497_09953

Replication factor A (482 aa)

0.997

priS

DNA primase, small subunit; Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. [...] (393 aa)

Flap endonuclease-1; Structure-specific nuclease with 5’-flap endonuclease and 5’-3’ exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5’-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5’-end of a downstream Okazaki fragment. Binds the unpaired 3’-DNA end and kinks the DNA to facilitate 5’ cleavage specificity. Cleaves one nucleotide into the double- stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. A [...] (325 aa)

a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1

node2

node1 accession

node2 accession

node1 annotation

node2 annotation

score

C497_06032

C497_07354

HacjB3_07625

HacjB3_12165

Ribonucleotide reductase subunit beta-like protein

DNA-directed DNA polymerase type II

0.488

C497_06032

C497_09953

HacjB3_07625

HacjB3_14720

Ribonucleotide reductase subunit beta-like protein

Replication factor A

0.617

C497_06032

C497_13251

HacjB3_07625

HacjB3_09425

Ribonucleotide reductase subunit beta-like protein

Nucleic acid binding OB-fold tRNA/helicase-type

0.617

C497_06032

C497_17517

HacjB3_07625

HacjB3_01800

Ribonucleotide reductase subunit beta-like protein

Nucleic acid binding OB-fold tRNA/helicase-type

0.617

C497_06032

C497_18517

HacjB3_07625

HacjB3_00820

Ribonucleotide reductase subunit beta-like protein

Ribonucleotide-diphosphate reductase subunit beta

0.800

C497_06032

fen

HacjB3_07625

HacjB3_08280

Ribonucleotide reductase subunit beta-like protein

Flap endonuclease-1; Structure-specific nuclease with 5’-flap endonuclease and 5’-3’ exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5’-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5’-end of a downstream Okazaki fragment. Binds the unpaired 3’-DNA end and kinks the DNA to facilitate 5’ cleavage specificity. Cleaves one nucleotide into the double- stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. A [...]

0.464

C497_06032

pcn

HacjB3_07625

HacjB3_02015

Ribonucleotide reductase subunit beta-like protein

Proliferating cell nuclear antigen; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication

0.994

C497_06032

priS

HacjB3_07625

HacjB3_07360

Ribonucleotide reductase subunit beta-like protein

DNA primase, small subunit; Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. [...]

0.661

C497_06032

rfc

HacjB3_07625

HacjB3_01150

Ribonucleotide reductase subunit beta-like protein

Replication factor C small subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA

0.416

C497_06032

rfcL

HacjB3_07625

HacjB3_06695

Ribonucleotide reductase subunit beta-like protein

Replication factor C large subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA

0.416

C497_07354

C497_06032

HacjB3_12165

HacjB3_07625

DNA-directed DNA polymerase type II

Ribonucleotide reductase subunit beta-like protein

0.488

C497_07354

C497_09953

HacjB3_12165

HacjB3_14720

DNA-directed DNA polymerase type II

Replication factor A

0.977

C497_07354

C497_13251

HacjB3_12165

HacjB3_09425

DNA-directed DNA polymerase type II

Nucleic acid binding OB-fold tRNA/helicase-type

0.976

C497_07354

C497_17517

HacjB3_12165

HacjB3_01800

DNA-directed DNA polymerase type II

Nucleic acid binding OB-fold tRNA/helicase-type

0.976

C497_07354

C497_18517

HacjB3_12165

HacjB3_00820

DNA-directed DNA polymerase type II

Ribonucleotide-diphosphate reductase subunit beta

0.488

C497_07354

fen

HacjB3_12165

HacjB3_08280

DNA-directed DNA polymerase type II

Flap endonuclease-1; Structure-specific nuclease with 5’-flap endonuclease and 5’-3’ exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5’-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5’-end of a downstream Okazaki fragment. Binds the unpaired 3’-DNA end and kinks the DNA to facilitate 5’ cleavage specificity. Cleaves one nucleotide into the double- stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. A [...]

0.966

C497_07354

pcn

HacjB3_12165

HacjB3_02015

DNA-directed DNA polymerase type II

Proliferating cell nuclear antigen; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication

0.995

C497_07354

priS

HacjB3_12165

HacjB3_07360

DNA-directed DNA polymerase type II

DNA primase, small subunit; Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. [...]

0.997

C497_07354

rfc

HacjB3_12165

HacjB3_01150

DNA-directed DNA polymerase type II

Replication factor C small subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA

0.977

C497_07354

rfcL

HacjB3_12165

HacjB3_06695

DNA-directed DNA polymerase type II

Replication factor C large subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA

0.977

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Functional enrichments in your networkNote: some enrichments may be expected here (why?)

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Statistical background

For the above enrichment analysis, the following statistical background is assumed: