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We report the results of a global analysis of dark matter simplified models (DMSMs) with leptophobic mediator particles of spin one, considering the cases of both vector and axial-vector interactions with dark matter (DM) particles and quarks. We require the DMSMs to provide all the cosmological DM density indicated by Planck and other observations, and we impose the upper limits on spin-independent and -dependent scattering from direct DM search experiments. We also impose all relevant LHC constraints from searches for monojet events and measurements of the dijet mass spectrum. We model the likelihood functions for all the constraints and combine them within the MasterCode framework, and probe the full DMSM parameter spaces by scanning over the mediator and DM masses and couplings, not fixing any of the model parameters. We find, in general, two allowed regions of the parameter spaces: one in which the mediator couplings to Standard Model (SM) and DM particles may be comparable to those in the SM and the cosmological DM density is reached via resonant annihilation, and one in which the mediator couplings to quarks are ≲10−3 and DM annihilation is non-resonant. We find that the DM and mediator masses may well lie within the ranges accessible to LHC experiments. We also present predictions for spin-independent and -dependent DM scattering, and present specific results for ranges of the DM couplings that may be favoured in ultraviolet completions of the DMSMs.