St. Louis Cardinals at San Francisco Giants

Each of the last 20 series between the Cardinals and Giants has resulted in no sweeps by either team. The only MLB series with a longer active streak is Milwaukee-San Diego, which has gone 22 consecutive series without a sweep by either club.

The Cardinals boast a higher winning percentage against left-handed starting pitchers (16-13, .552) than they do versus right-handers (50-53, .485). The 67-point improvement versus southpaws is the second-largest by the Cardinals since 2000 (2012, .646/.500/+.146).

The Giants have scored runners from third base with fewer than two outs (via an RBI) in 60.6 percent of their opportunities, the second-highest rate in the majors this season (Colorado, 61.5).

With a pair home runs on Wednesday, 15 of Tommy Pham's 19 homers this season have come on the road. In addition, 25 of his 33 career home runs have occurred away from home. Pham's 1.048 OPS in road games this season ranks fourth in the majors (minimum 200 PA).

After going 6-1 with a 2.22 ERA over eight starts between June 26 and August 8, Michael Wacha has compiled a 10.22 ERA while losing each of his last three starts. Opponents are batting .414 over those recent three outings, during which Wacha has averaged just 4.11 innings per start.

Madison Bumgarner has hit two home runs in 2017. If he connects before the end of the season, he'll become the first pitcher to total at least three homers in four consecutive seasons since Earl Wilson between 1964 and 1968 (five).

SAN FRANCISCO -- Jack Flaherty's debut and Johnny Cueto's comeback will find them sharing the same pitchers' mound Friday night when the St. Louis Cardinals and San Francisco Giants continue their four-game series.

Right-hander Michael Wacha was the dominant force on the mound Thursday in the series opener, pitching the Cardinals to a 5-2 win.

Starting a stretch of eight consecutive games against the bottom two teams in the National League West, the Cardinals (67-66) took a first step at a run at the second wild-card spot with the win, which moved them to within five games of the Colorado Rockies (72-61).

Flaherty, 21, not only will make his major league debut in the heat of a playoff race, but he also will be the youngest Cardinals pitcher to start in his first game since Rick Ankiel debuted as a 20-year-old in 1999.

The right-hander, who won't turn 22 until Oct. 15, will be the 14th-youngest Cardinal ever to appear in a major league game.

The 2014 first-round pick out of Harvard-Westlake School in Los Angeles was 7-2 with a 2.74 in 15 starts for Triple-A Memphis after an in-season promotion. Flaherty began the year 7-2 with a 1.42 ERA for Double-A Springfield.

"Injuries open doors for things like this to happen," said Cardinals manager Mike Matheny, whose team remains without one of its top starters, Adam Wainwright, sidelined due to a sore elbow.

Matheny realizes he is now counting upon a youngster who already has thrown 148 2/3 innings in the minors this season.

"Right now, we're not allowing limitations," he said when asked if Flaherty had some type of innings cap, "but there certainly could be. Trying to get what we can and not have him think about limiting in any way."

Flaherty will be opposed by a 10-year veteran who landed in the majors in 2008 as a 22-year-old.

Cueto authored an impressive major league debut, limiting the Arizona Diamondbacks to one run and one hit over seven innings. He struck out 10 and was the winning pitcher in the Cincinnati Reds' 3-2 victory.

Cueto (6-7, 4.59 ERA) has won 119 more games since then, but none since June 30 at Pittsburgh. The 31-year-old experienced blisters on his pitching hand two starts later against the San Diego Padres on July 14, and he hasn't pitched in the majors since.

He did make three injury-rehab starts in the minors since then, going 0-1 with a 4.66 ERA, but his path to a major league return was stalled by a strained flexor tendon.

Cueto is 7-8 with a 3.75 ERA in 22 career starts against the Cardinals.

He will be backed by a Giants team that figures to be inspired to do more than just snap a three-game losing streak.

To a man, the last-place club left the ballpark Thursday night believing that shortstop Brandon Crawford had been jobbed out of a home run by a head-scratching overturn by the New York review crew in the ninth inning.

It took the video staff four full minutes to reverse what had been called a home run on the field, citing that a Giants fan who caught the ball near the right field foul pole had reached into the field of play.

Crawford was given a double.

"They're saying it was fan interference. They're wrong," Giants manager Bruce Bochy said afterward. "Terrible overturn there. Shocked all of us. It's a home run taken away from Craw."