Human Zinc Finger Protein 24 (ZNF24) Interaktionspartner

In vivo, knockdown of ZNF24 specifically in microvascular endothelial cells led to significantly decreased formation of functional vascular networks.

results suggest that consecutive ZF1 (zeige PRMT1 Proteine)-2 is critical for the regulation of ZNF24 nuclear localization and its transactivation function.

ZNF24 represses VEGF (zeige VEGFA Proteine) transcription through direct binding to an 11 (zeige DCAF7 Proteine)-bp fragment of the VEGF (zeige VEGFA Proteine) proximal promoter and that it functions as a negative regulator of tumor growth by inhibiting angiogenesis.

ZNF24 may be implicated in transcriptional regulation of genes associated with oncogenesis via interaction with H2A.Z (zeige H2AFZ Proteine).

ZNF191 can directly bind to the CTNNB1 (zeige CTNNB1 Proteine) promoter and activate the expression of beta-catenin (zeige CTNNB1 Proteine) and its downstream target genes such as cyclin D1 (zeige CCND1 Proteine) in hepatoma cell lines.

These data suggest that ZNF24 is involved in negative regulation of PDGFR-beta (zeige PDGFRB Proteine) and may represent a novel repressor of PDGFR-beta (zeige PDGFRB Proteine) transcription.

Overexpression and purification of single zinc finger peptides of ZNF191 were performed.

ZNF191 is a pleiotropic factor that has a role in hematopoiesis, brain development, and tumor growth.

Data confirm ZNF191 as an essential factor acting for the promotion of the cell cycle and thus maintenance in the progenitor stage.

Zinc Finger Protein 24 (ZNF24) Protein Überblick

Protein Überblick

Transcription factor required for myelination of differentiated oligodendrocytes. Required for the conversion of oligodendrocytes from the premyelinating to the myelinating state. In the developing central nervous system (CNS), involved in the maintenance in the progenitor stage by promoting the cell cycle. Specifically bind to the 5'-TCAT-3' DNA sequence. Has transcription repressor activity in vitro.