Inside Cover The Engineering of an Orally Active Conotoxin for the Treatment of Neuropathic
Pain (Angew. Chem. Int. Ed. 372010)

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.
Sea
snails of the Conus genus …
… produce bioactive peptides in their venoms to capture prey, but chemists can reengineer these peptides for drug-design purposes. In their Communication on
page 6545 ff., D. J. Craik and co-workers describe how the chemical cyclization of a
peptide from Conus victoriae was used to produce a stable and orally active drug lead
that is a potent analgesic in a rat model of neuropathic pain. Image design: David
Wilson.
Inside Cover
Richard J. Clark, Jonas Jensen, Simon T. Nevin, Brid P. Callaghan,
David J. Adams, and David J. Craik*
Sea snails of the Conus genus produce bioactive peptides in their venoms to capture
prey, but chemists can re-engineer these peptides for drug-design purposes. In their
Communication on page 6545 ff., D. J. Craik and co-workers describe how the
chemical cyclization of a peptide from Conus victoriae was used to produce a stable
and orally active drug lead that is a potent analgesic in a rat model of neuropathic
pain. Image design: David Wilson.