In the present study, the in vitro activity and interaction of terbinafine in combination with fluconazole were investigated against 31 clinical isolates of Candida albicans. With microdilution method the MIC ranges and MICs required to inhibit 50 and 90% of the test isolates (MIC50s and MIC90s, respectively) of terbinafine were 0.25->8 µg/ml and 8->64 µg/ml; of fluconazole were 0.25->64 µg/ml and 16-64 µg/ml. With checkerboard method the combination of these two antifungals were additive for 18 (58%) and synergistic for 13 (42%) isolates. Antagonism was not observed. These findings are encouraging, however, in vitro and in vivo correlation should be investigated in controlled clinical studies.