5,6-Dehydrokawain

One of the six main active ingredients (α-pyrones) of kava kava, found to have antiplatelet activity, which is due to the inhibition of thromboxane A2 formation.

PRODUCT PROPERTIES

Formula:

C14H12O3

MW:

228.25

CAS:

1952-41-6

Purity:

≥98%

Long Term Storage:

-20°C

Miscellaneous/General:

Kava extract is prepared from the south pacific plant called Piper methysticum. The most often used extract has an enriched kavalactone content of 30%. The kava lactones (α-pyrones) appear to be the activ ngredients responsible for the sedative and psychoactive properties of kava [1, 2]. There is dose dependent efect of these pure components on the influence of dopamine level [3, 4]. Low dose kavain treatment in rat elicits a decrease in dopamine level while high dose or chronical administration of the same compound produce no change in dopamine or serotonine level in tissues of rats. Several pure components of kava have been found to inhibit MAO-B in intact human platelets which was thought to be an important mechanism for their psychotropic activity [5]. The specific binding behavior of the GABA-A receptor was found to be altered by these compounds as well.