Antipsychotic Use in Parkinson's Linked to Mortality Risk

HealthDay News — Parkinson's disease patients who are given antipsychotics to treat dementia and psychosis may be more likely to die early, according to research published in JAMA Neurology.

The study focused on 7877 Parkinson's patients in the Veterans Affairs system who took antipsychotics (mostly men, with an average age of 76). The researchers compared them to 7877 Parkinson's patients in the VA system who didn't take the drugs.

The investigators found that those who took antipsychotics were more than twice as likely to die over 6 months as those who didn't (intent-to-treat hazard ratio, 2.35). Those who took the older typical antipsychotics (especially Haldol) were at highest risk. The study didn't pinpoint the risk of death for those who didn't take the drugs. While the study focused almost entirely on men, the researchers said the experiences of women would probably be the same.

"This [study] does not necessarily answer whether the drugs themselves lead to more deaths, or if it's instead the reasons they were prescribed," Mark Baron, MD, interim director of the Virginia Commonwealth University's Parkinson's Disease and Movement Disorders Center in Richmond and author of a commentary accompanying the study, told HealthDay.