The neighborhood that launched the original House of Blues will have a voice in the area’s live music circuit starting this fall, as today New York-based The Bowery Presents officially announced the 525-person-capacity venue THE SINCLAIR, a multi-level, multi-use space located at 52 Church Street.

In terms of capacity, The Sinclair will be the second-largest rock club in Cambridge, behind only the 595-person Middle East Downstairs. And much like the Central Square complex, the Sinclair will have a restaurant component: a 104-seat eatery headed up by consulting chef Michael Schlow (Radius, Via Matta, Tico). Included are two dining areas and “a seasonal patio,” which will be separated from the live music venue by its own entrance. The club area will feature a wraparound mezzanine level with its own bar and sound system built by d&b audiotechnik.

“We are excited to open the Sinclair in such a historic, dynamic neighborhood,” says Jim Glancy, co-owner of The Bowery Presents.

Last week, The Bowery Presents expanded its Boston team by hiring Carl Lavin and Josh Smith of CQ Presents, the independent booking agency that oversaw Allston’s Great Scott and T.T. The Bear’s Place in Cambridge. Those two clubs will now join with Bowery’s Tremont Street nightclub Royale and the Sinclair to form a network of venues with capacities that range from 240 (Great Scott) to 775 (Royale).

“The Bowery Presents has based the core of its business on highlighting a wide cross section of great music while delivering first-class hospitality to both artists and guests, which will continue at The Sinclair,” says Josh Bhatti, who heads up The Bowery Presents: Boston. “Having lived in the Boston area my whole life, I am ecstatic to be a part of bringing what I truly believe will be the best music venue in my hometown. Working with Michael Schlow and his team has been great, and we plan to launch a restaurant that will be a destination and a welcome addition to the neighborhood.”

The Sinclair was designed and built by Boston-based Tribeca Builders, and according to a press release, will “possess timeless American influences and embody how the worlds of food and music influence each other.”

Schlow says: “I’m always looking for new and exciting ways to incorporate music into my restaurants, and this project takes the music side to a whole new level. Music is inextricably linked to the dining experience and I’m excited to be part of the Sinclair.”