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how to remove yellowed areas on shirts

I found a dress shirt of my son's that has yellowed spots on the cuff and part of the front. I guess they are from age. I don't think it's a spill, based on where it is. I treated it with that oxy spray stuff the first time and it helped, but didn't completely clean it. Any other suggestions?

You could try the oxy spray again. I've removed old stains/spots just by repeating the the stain remover a few times. You could also try a color safe bleach. Before you wash it, dab some directly onto to the spots, rub it in, and let it sit for a while. GL