The film is composed of multiple comedy shorts presented through an overarching segment titled “The Pitch”, in which Charlie Wessler, a mad screenwriter, is attempting to pitch a script to film executive Griffin Schraeder. After revealing several of the stories in his script, Wessler becomes agitated when Schraeder dismisses his outrageous ideas, and he pulls a gun on him and forces him to listen to multiple other stories before making Schraeder consult his manager, Bob Mone, to purchase the film.

Family Guy creator Seth MacFarlane brings his boundary-pushing brand of humor to the big screen for the first time as writer, director and voice star of Ted. In the live action/CG-animated comedy, he tells the story of John Bennett, a grown man who must deal with the cherished teddy bear who came to life as the result of a childhood wish, and has refused to leave his side ever since.