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Romantic Road or Moselle Valley - Strasbourg, Normandy and Brittany

We will be travelling to Germany and France for 3 weeks at the end of May, beginning of June. We will land in Frankfurt and fly home from Paris and will rent a car. I have some ideas, but would like some feedback.
We thought we'd start out by driving to Rothenburg and visit the towns along the Romantic Road for 4 nights. Plan B would be to drive to Koblenz area and do the Rhine Valley/Moselle Valley for 4 nights. Which area do you prefer?
We would then drive to Strasbourg and stay for 3 nights. That would be week 1. For the next 2 weeks we are thinking of driving to Normandy, with a stop along the way. (One night, perhaps Reims) What would be a good base for Normandy for 3 nights? Is Rouen too far for day trips? From there we are thinking Brittany, but not much further than Treburden - for 3 nights. Any suggestions for the last week, given that we would like a drive back to Paris of only 3 to 4 hours on the day before we leave? We prefer to stay more than 1 night in a town and do daytrips.
I haven't been on this board for a while, but in the past Fodorites have been extremely helpful.