From the Erol Project Development House for the Disorders of Energy Metabolism, Silivri-Istanbul, Turkey

Corresponding author: Adnan Erol, eroladnan{at}hotmail.com.

In their article, Kumar et al. (1) demonstrated the importance of mTORC2 for the insulin-induced glucose transport and lipolysis in adipocytes. They also discussed
the mechanisms of the fat-cell–specific deletion of rictor and alterations in the insulin signaling pathway, leading to systemic insulin resistance. They suggested that the increased
serum nonesterified fatty acid levels in FRic−/− mice are the mediators for the impairment of the whole-body insulin sensitivity (1). Previously, Cybulski et …