When someone blows you up it means they let many others know about something you're doing, or what you have that you don't want others to know. A place can get blown up as well, for example if you know a chill spot where a selected few come to hangout, it could get blown up if a lot of people find out that it's cop free and chill.

"Can I have a cigarette?"
"I don't have any, ask David though"
"Fool, why you gotta blow me up?!"

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Much like smoking or drinking someone up, "blowing up" in this context refers to giving someone free coke.

Person 1: "I wanted to leave for that party, but Andrew just wanted to keep doing lines at his apartment."
Person 2: "Did he at least blow you up?"
Person 1: "Yeah, I got a bunch of free blow-ups. Did you make that up just now? It's pretty good."