NFL Week 10 upset picks: New York Giants have realistic shot in San Francisco

The Giants are not as bad as their high-profile loss to the Eagles in primetime might indicate, and it wouldn't be altogether surprising if Saquon Barkley and the running game pushed them past the 49ers in San Francisco on Monday night. Rich Graessle/Icon Sportswire

Week 10 in the NFL is not a week for close games. As of Wednesday night, every single game on the schedule had a line of at least three points. That means every game this week is eligible to be chosen as our Upset Watch for the week. But for the game that we think is the most likely upset, you have to wait all the way to the end, when Monday Night Football airs on ESPN.

Lines courtesy of the Westgate Las Vegas SuperBook, as of Thursday morning.