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Long-Read NGS Library Prep

Advanced Analytical Technologies

The FEMTO Pulse is designed to meet the needs of next-generation sequencing (NGS) systems analyzing ever-longer DNA fragments. Analyzing fragments over 50,000 base pairs (bp) long and using smaller sample quantities, researchers require an automated system to quantify and qualify their genomic DNA libraries, from initial quality control to final validation. The FEMTO Pulse, an automated pulsed-field capillary electrophoresis system, accurately sizes fragments as large as 165,000 bp and measures samples at concentrations as low as 5 fg/µL. Runtimes are approximately one hour versus up to 16 hours needed for methods such as agarose-based, pulsed-field gel electrophoresis. These improvements push the boundaries of nucleic-acid detection and fragment sizing, affecting applications such as single-cell nucleic acid analysis, PCR-free preparation of NGS library preparation, bacterial artificial chromosome clone sizing, and exosome analysis.

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