In 1986, she married Saddam Kamel al-Majid, brother of Hussein Kamel al-Majid, her elder sister Raghad's husband, to whom she bore four children. She accompanied her husband to Jordan in 1995, where she lived from August 8 of that year to February 20, 1996. They returned to Iraq after receiving assurances from Saddam Hussein that he would pardon Kamel and his brother, Hussein Kamel al-Majid. Despite this promise, before the end of the month both Kamels were shot and killed by other clan members who declared them traitors.

In 1997, her brother Uday Hussein put Rana and her sister Raghad under house arrest for being involved in a plot to assassinate him.

On July 31, 2003, she went back to Jordan, where the king, Abdullah, granted her family asylum.

Rana is the mother of three sons, Ahmad, Saad and Hussein, and a daughter named Nabea.