1Department of Bioengineering,
University of California San Diego, La Jolla, CA, United States; 2Department
of Radiology and Psychiatry, University of California San Diego, La Jolla,
CA, United States

We
introduced a new method to image oxygen extraction fraction noninvasively
using velocity selective excitation with arterial nulling (VSEAN). Compared
to the QUIXOTIC method, VSEAN has following advantages: 1) higher SNR due to
more relaxed venous blood; 2) no subtraction gives higher time efficiency; 3)
insensitive to physiological noise; 4) a T2 map is generated every TR from
multi-echo acquisition. Sequence design details were discussed and results
from a human subject were presented.