Results: The mean number of prior injection was 13.3±5.1 during a mean of 44 months of follow-up (15-76).The mean duration after
switching was 7.2±1.7 months (5-11) with an average number of 2.5±0.8 (2-5) injections. The mean CMT and maximal PED height
improved signifi cantly (p<0.001), whereas the mean BCVA remained stable over time. Changes in visual acuity was not associated
with reduction in PED height (R²= 0.07, p=0.73). Eighty percent of patients remained visually stable, 10% gained two or more lines,
and 10% lost two or more lines of visual acuity after switching. Complete resolution of intraretinal or subretinal fl uid was observed in
75% of the treated eyes.

Conclusion: The morphological improvements were achieved following PRN regimen of AFL injection in our diffi cult-to-treat patient
population (PED cohort), but there was no concomittant increase in visual acuity.