Description

Androgenic remedies

The main hormone secreted by the sex glands in the male body is testosterone.

It is a substance of the steroid structure, which, entering the bloodstream in the target tissue, penetrates the cells and acts like other steroid hormones.

It binds to intracellular cytosolic receptors and activates them. The resulting hormone-receptor complex penetrates into the nucleus, where it interacts with specific regions localized in the genes and changes the transcription of the protein genes.In some tissues (in the skin, hair follicles, prostate, seminal vesicles), testosterone under the influence of 5a-reductase is converted into dihydrotestosterone, which in these tissues is an active form of the hormone. Dihydrotestosterone binds more firmly to receptors and its effect is more pronounced.

Effects of androgen hormones

Conditionally it is possible to divide into 2 groups:

Androgenic

– stimulation of development of male genital organs and secondary male sexual characteristics

– stimulation of male sexual behavior

Anabolic

– increased growth and increased muscle mass

– stimulation of erythropoiesis

Indications for use:

· Based on substitution therapy

– Male hypogonadism and lag in sexual development

– Involutional disorders in men associated with the extinction of sexual function

· In the calculation of suppression of the gonadotrophic function of the pituitary gland (suppressive, suppressive therapy)

– tumor diseases of the breast in women.

Undesirable effects of androgenic drugs

· Acne

· Erythrocytosis

· Gynecomastia (due to transformation in peripheral tissues into estrogens)

Oligo and azoospermia (due to oppression according to the negative feedback principle of production of follicle-stimulating hormone of the pituitary gland)

· Reducing the size of the testicles (for the same reason as the previous one)

· Increase in the size of the prostate gland (due to the conversion to a more active dihydrotestosterone)