Speaker Biography

Biography:

I have recently completed a Ph.D. degree in microbiology specializing in infectious diseases at Aix-Marseille University, France. I am very much interested in the field of gut microbiome research and antibiotic resistance. I have a dual competence as a pharmacist and microbiologist. I mainly worked in the exploration of the gut microbiota by culture and metagenomics and the implication of the digestive microbiota in metabolic diseases such as diabetes and in infectious diseases. Therefore, I have strong technical skills in the culture and identification of microorganisms, molecular biology techniques, and bioinformatics. I'm one of the pioneer students who worked on the microbial culturomics, a concept initiated by Prof. Didier RAOULT.

Abstract:

High salt intake has been linked to several diseases including obesity and an increased risk of death; however, fecal salinity and the ability of salt to alter the gut microbiota, which was recently identified as an instrumental factor for health and disease, remains poorly explored. We analyzed fecal samples of 1,326 human individuals for salinity and gut microbiota by culturomics and metagenomics. Geographical origin, age, gender, and obesity were tested as predictors of fecal salinity and halophilic diversity. All halophilic isolates were characterized by taxonogenomics and their genome sequenced. Fecal salinity was associated with obesity independently of geographical origin, gender, and age. The first 2 human-associated halophilic archaeal members were isolated along with 64 distinct halophilic species, including 21 new species and 41 known in the environment but not in humans. No halophiles grow in less than 1.5% salinity. Above this threshold, the richness of the halophilic microbiota was correlated with fecal salinity (r = 0.58, p < .0001). Metagenomics linked high fecal salinity to decreased diversity (linear regression, p < .035) and a depletion in anti-obesity Akkermansia muciniphila and Bifidobacterium, specifically B. longum and B. adolescentis. Genomics analysis suggested that halophilic microbes are not only transient passengers but may be residents of the human gut. High salt levels strongly alter the gut microbial ecosystem and are associated with the human halophilic microbiota, discovered in this study. Further studies should clarify if the gut microbiota alterations associated with high salt levels and the human halophilic microbiota could be causally related to human diseases, such as stomach cancer and obesity.

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