How do we detect if coronavirus is spreading in the community?

Author

Associate Professor, Molecular Engineering, University of the Sunshine Coast

Disclosure statement

Dr. Joanne Macdonald is the Chief Technology Officer (CTO) and owns shares in BioCifer Pty. Ltd, which develops rapid diagnostic technology for disease detection. Either through her industry work or her academic research at the Unviersity of the Sunshine Coast (USC), she has current research or development funding from the National Foundation of Medical Reserarch Innovation (NFMRI), the Childrens Hospital Foundation (CHF), and the DMTC Medical Countermeasures Program. Dr. Macdonald is also the Chair of the Virology Special Interest Group for the Australian Society of Microbiology.

Our disease surveillance systems are well placed to keep abreast of COVID-19 and provide some reassurance that transmission is unlikely to go undetected in the community. But there’s still more we could do.

Why is the coronavirus hard to detect?

Detecting all people with COVID-19 is a global problem. There are too many existing respiratory infections, such as colds and flus, in any country to be able to test everyone with coronavirus symptoms.

There are not enough testing kits readily available to test people at this scale.

So who is tested?

In Australia, people are currently tested for the coronavirus if they’ve travelled from or through a country considered to pose a risk of transmission in the 14 days before getting sick, or if they have a link to a known case.

This testing criteria has changed as the outbreak progressed, and will continue to do so.

Currently, only those with a relevant travel history or contact with a known case are tested.Shutterstock

How else do we track possible cases?

Apart from directly testing people suspected of having COVID-19, Australia has a surveillance plan to detect coronavirus in people or populations who don’t know they’re infected.

The Australian Sentinel Practices Research Network (ASPREN) is a network of GPs who log the number of patients they see in total, compared to the number of patients they see with influenza-like illness. These GPs collect samples from a small subset of those patients to see if COVID-19 is circulating. Samples are then sent to SA Pathology for testing.

Another surveillance network that may be activated is FluCAN. This reports on the number of hospitalisations due to a disease, usually influenza, as well as clinical data from the cases. The information helps public health experts get a better picture of how severe the disease is, and the symptoms.

But while these systems can monitor disease levels in those sick enough to seek medical care, they don’t give us an indication of the amount of milder disease that might be circulating in our communities.

It’s unclear how long surveillance systems take to detect community transmission.James Gourley/AAP

This is where an online surveillance system called FluTracking can help. Anyone in the community can join and answer two simple questions each week about whether they have a fever and/or a cough.

The system provides information on how much influenza-like illness is circulating in the community. If we’re seeing more than usual, it might signify a community outbreak.

Australia’s emergency response plans include provisions to mobilise flu clinics to help keep patients from overwhelming emergency services. Drive-through services could be an excellent addition to these existing plans.

Rapid testing

One of the biggest concerns with current testing is the time it takes to ship a sample to a laboratory for testing. This can result in a delay of one to two days before getting the results. During peak epidemic times, testing can’t cope with demand.

Researchers in China, however, have reportedly developed a rapid coronavirus test that can detect the virus using a fingerprick of blood in 15 minutes. The test detects if the body has mounted an immune response (Ig M antibodies) to the virus.

Rapid diagnostic tests are typically cheap to manufacture, can be mass produced, and can be easily used by health workers outside a laboratory.

Reporting on negative test results and surveillance systems

Positive COVID-19 cases from all the surveillance sources are reported as they occur. But while influenza surveillance reports include the number of negative tests results, it’s unclear whether COVID-19 surveillance reports will do the same.

Reporting on negative tests results could help ease community concern that coughs and sneezes people see on the train or in their office are unlikely to be due to the undetected spread of COVID-19.

Local health services should also provide regular updates on the types of COVID-19 surveillance actively being performed, and in which communities. This information can help reduce anxiety levels and assure communities that spread of coronavirus can be effectively monitored.