chromatolysis

2. disintegration of the Nissl bodies of a neuron as a result of injury, fatigue, or exhaustion.

chro·ma·tol·y·sis

(krō'mă-tol'i-sis),

The disintegration of the granules of chromophil substance (Nissl bodies) in a nerve cell body that may occur after exhaustion of the cell or damage to its peripheral process; other changes considered part of chromatolysis include swelling of the perikaryon and shifting of the nucleus from its central position to the periphery.

Beginning on day 5, however, neuronal degeneration was seen in many areas, manifested by shrinkage of the perikaryon with intense eosinophilia of the cytoplasm, central chromatolysis, and condensation of the nucleus.

Vestibulocochlear Wallerian-like degeneration and retinal ganglion cell chromatolysis were also seen in dogs treated for 14 weeks at 180 mg/kg/day, a dose which resulted in a mean plasma drug level (Cmax) similar to that seen with the 60 mg/kg/day dose.

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