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Life Course Socioeconomic Status, Social Context and Cardiovascular Disease: The LCSES Study Kathryn Rose, PhD for The LCSES Study Team

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Background

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LCSES and ARIC Studies  As part of the ARIC study, information on mid to later life socioeconomic status (SES) was collected at each of the four examinations  As an ancillary study, LCSES collected additional information from surviving participants about earlier life SES circumstances  Individual-level SES  Place of residence

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LCSES Study Goals  Examine the association between SES across the life course and CVD-related outcomes  Determine the extent to which the current and historical (neighborhood) context modify the association of individual-level SES exposures and CVD events  Identify explanatory mechanisms for the SES- CVD association

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Childhood Place of Residence  City / County / State of Residence during childhood  Data cleaning / editing  3% resided outside of the US  44% resided in the same county as in midlife  Linking with county-level census data  Chose decennial census (1930, 1940, 1950) that corresponded most closely to where participant lived at 10 years of age  Of the 12,314 participants who lived in the US as children, 99% were linked to county-level census data

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Place of Residence at Ages 30, 40, and 50  Participants asked to provide their complete street address  Goal: link with census tract data from historical census (1960 – 1980) most closely corresponding to the given age  Only queried about address for a given age if not already in ARIC at this age

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Progress to Data  Strategies for working with complex historical census data have been developed  Individual and contextual / neighborhood socio- economic exposure data across the life course has been assembled for study participants  Various research projects focusing on cardiovascular disease related outcomes are in progress