Despaigne leads Padres past Giants 6-0

San Diego Padres' Yasmani Grandal (8) hits a double to drive in a run against the San Francisco Giants during the fourth inning of a baseball game in San Francisco, Monday, June 23, 2014. (AP Photo/Tony Avelar)

SAN FRANCISCO (AP) — Cuban defector Odrisamer Despaigne pitched seven innings in his major league debut to lead the San Diego Padres to a 6-0 victory over the San Francisco Giants on Monday night.

Tommy Medica hit a two-run double off Matt Cain (1-6) after the umpires took away a three-run home run by Yasmani Grandal on a replay review to give the crafty Despaigne (1-0) the support he needed to get the win.

Despaigne had a 6.03 ERA in seven minor league starts in his first season as a professional after defecting from Cuba last summer. But he kept the Giants off-balance all game by changing his arm angle and mixing in big, slow curveballs with his harder pitches.

Despaigne allowed four hits and no walks in place of the injured Andrew Cashner, who was placed on the disabled list with a sore shoulder earlier in the day.

The Giants lost for the 10th time in 13 games.

Neither team had a hit in the first three innings before the Padres got to Cain in the fourth. The rally started when Everth Cabrera reached on a one-out infield single and advanced to third on Seth Smith's single.

One out later, Grandal hit a drive to right-center that initially appeared to clear the wall for a three-run homer. But right fielder Hunter Pence immediately signaled that a fan interfered on the play and ran toward the umpires to protest.

The umpires called for a video review and the play was changed to a double with Smith being sent back to third base even though he most likely would have scored easily from first on a two-out hit to the deepest part of the stadium.

Padres manager Bud Black ran out of the dugout to challenge the ruling and was immediately ejected by crew chief Brian O'Nora.

The call became moot when Medica followed with a two-run double to make it 3-0 as Cain struggled once again.

The Padres tacked on three runs in the eighth with an RBI single by Cabrera, a run-scoring double to Smith and a throwing error by Pence.

Cain allowed six runs and seven hits in 7 1-3 innings and has just one win in 12 starts this season.

NOTES: There was a pregame video tribute to Padres Hall of Famer Tony Gwynn, who died last week at age 54. There was also a No. 19 honoring Gwynn on the wall in right field. ... Padres 3B Chase Headley (back) missed his fourth straight game but could return Tuesday. ... Giants OF Angel Pagan (back) missed his seventh straight game. ... Giants INF Marco Scutaro (back) is scheduled to play three innings on a rehab assignment in the Arizona League on Tuesday. ... Tim Hudson (4-2) starts the second game of the series for San Francisco against Jesse Hahn (2-1).

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