Chemokine CC Receptors

Chemokine CC receptors (CCRs) predominantly recognize CC chemokines. CC chemokines are distinguished by having four conserved cysteines, with the first two cysteines being adjacent to each other. There are 10 chemokine CC receptors.

Chemokine CC receptors (CCRs) predominantly recognize CC chemokines. CC chemokines are distinguished by having four conserved cysteines, although a small subgroup has six cysteines, with the first two cysteines being adjacent to one another. There are 10 chemokine CC receptors, with each one having a distinct chemokine and leukocyte specificity.

CC chemokines have a key role in the recruitment of monocytes and macrophages, cells types that are important in a number of chronic inflammatory conditions, such as atherosclerosis, rheumatoid arthritis, adipose inflammation, multiple sclerosis, asthma and Crohn's disease. CCR antagonists have been investigated clinically for these and other disorders. In addition, CCR5 acts as a coreceptor for HIV entry into CD4+ cells and antagonists of CCR5, such as maraviroc, have been developed to treat HIV infection.

Asthma Poster

Asthma is one of the most common chronic diseases in the world, affecting over 300 million people. This poster highlights key pathways and new therapies used to treat the condition, including those currently in clinical development.