A study following a group of men who have prostate cancer and gene changes (GENPROS)

Cancer type:

Prostate cancer

Status:

Open

Phase:

Other

This study is looking at whether there are differences in how well prostate cancer treatment works if you have certain gene changes.

We know from research that men who have changes (mutations) to certain genes such as the BRCA1 and BRCA2 gene have an increased risk of developing prostate cancer. And if you are diagnosed with prostate cancer it may be more likely to grow and spread if you have one of these gene changes.

Cancer Research UK supports this trial.

More about this trial

In this study, the researchers aim to follow up a group of men who have prostate cancer and who are known to have certain gene mutations. Gene mutations that researchers are looking for include:

the BRCA 1 or BRCA 2 gene

the HOXB13 gene

the lynch syndrome genes

the ATM gene

other genes thought to be related to prostate cancer

They will also follow up a group of men diagnosed with prostate cancer who are known not to have one of these gene changes. This is called a control group. They will compare the groups to see how the men get on after treatment.

You are unlikely to get any direct benefit from taking part in this study. But the researchers hope that the information they collect will show if there are differences in how likely the cancer is to grow and spread.

The long term aim is to improve their understanding of prostate cancer, meaning they will be able to give better advice about treatment.

Who can enter

You may be able to join this study if all of the following apply.

You have prostate cancer

It is known whether or not you have certain changes (mutations) to genes – your doctor can tell you more about this

You are at least 18 years old

You cannot join this study if any of these apply.

You have been diagnosed with prostate cancer while taking part in the IMPACT study

It isn’t known whether or not you have certain gene changes

Trial design

The researchers hope that around 3,660 men will join this study. If you agree to take part, you are giving the study team permission to look at your medical records. They will also ask for samples of your prostate cancer that are removed when you have a biopsy or surgery.

The study team will ask your doctors for an update on your treatment and how you are getting on every year. All the information collected about you is confidential.

The study team will ask you to give a sample of saliva or blood that they can use to study your DNA.

The researchers may look for inherited genes that could affect your risk of developing prostate cancer or how likely it is to grow and spread. There is a possibility that they may find information that could be relevant to you or your family’s medical care. If this happens, the study team may want to contact you. But when you agree to join the study, you can mark on the consent form if you do not want to be contacted with this information.

The study team may also speak with relatives of people who passed away due to prostate cancer and would be eligible for this research. They will ask their permission to look at tissue samples that were taken during surgery or biopsies. They also ask for permission to access their relatives’ prostate cancer medical records.

Hospital visits

You may need to make an extra visit to hospital to discuss the study and give your saliva or blood sample.

Side effects

Blood tests are very safe and the team doesn’t think you will have any side effects from taking part in this study.

Talking about your, or your loved one cancer can be upsetting. The research team will do all they can to make you feel comfortable. They can give you information about support if you need it.

Location

Aberdeen

Birmingham

Cambridge

Cardiff

Dundee

Exeter

Leeds

Liverpool

London

Manchester

Newcastle upon Tyne

Nottingham

Oxford

Southampton

Recruitment start:

16/09/2014

Recruitment end:

31/12/2020

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

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