Donna Gates

Butyrate, oxalates and sleep are all closely tied to the health of the microbiome. Here are a few snippets from some of my favorite interviews on the Microbiome Medicine Summit 2:

Healthy Messages from Body to Brain: Dr. David Perlmutter

Butyrate is one of the 3 very important short chain fatty acids that are made in the gut: butyrate, propionate, and acetic acid are the products of the healthy bacteria.

And it turns out that butyrate has some far reaching effects in the body. It acts as a fuel for the cells that line the gut. It acts as a modulator of our gene expression, a fancy term called histone deacetylase inhibitor, but it changes the expression of our DNA.

It regulates the leakiness of the gut lining. It regulates the leakiness of the blood brain barrier, and it also simulates specific receptors on immune cells called G protein receptors that code for things like the formation of inflammatory chemicals, so it has wide-ranging effects.

We can increase our butyrate by having healthier gut bacteria. We can eat butyrate in certain foods. It comes from the word butter; butter is probably nature’s richest source of butyrate.

Special Diets & the Microbiome: Julie Matthews

What’s interesting about oxalates is they can affect and actually damage mitochondria. Mitochondria, those little powerhouses in the cell, there are millions and millions of those going on every second that supply our entire body, every cell, every organ of our body with energy at every second.

Issues with mitochondria are very common not only on autism but variety of conditions including fibromyalgia and all sorts of pain-related condition. And we often see when people have mitochondrial issues that they have issues with three or more systems. So if they’ve got issues with their gut and maybe something in their central nervous system or their immune system.

And interestingly, there is a microbiome connection with oxalates as well. And what that is, is that oxalates have to be broken down by good bacteria, particularly there is a bacteria called Oxalobacter formigenes and its job is to break down oxalates. There are other bacteria. There are Lactobacillus bacteria that can help break down oxalates, as well. Oxalobacter is particularly sensitive to antibiotics. Even a single round of antibiotics can really damage this population, sometimes not only for the short-term but sometimes for the longer term, particularly when someone has had multiple rounds.

Cleansing the Microbiome: Donna Gates

People probably don’t have this picture of the microbiome in their mind. But it’s very dynamic. It changes all the time. If you change your diet, your microbiome is going to change. If you travel, it’s going to change because you’re eating different foods and so on.

It’s also very cyclical. So, what happens at night when we go to sleep—the microbiome changes. There are certain microbes that become dormant—become quiet. And they don’t do anything much. And other ones become very active at night when we’re sleeping.

What happens if you have sleep disorders—like sleep apnea, for example, where you’re not breathing well at night—that’s going to change the diversity of the microbes in your gut. So, you want to correct sleep disorders.

You may not realize that when you don’t sleep, you’re harming the microbes in your gut. And you’re allowing the pathogenic crypts to have a heyday down in the gut. So, sleep is very important, very much connected to the microbiome.