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Recent documents in Scholar Works at Hardingen-usFri, 22 Feb 2019 04:01:49 PST3600Promoting and maintaining diversity in pharmaceutical educationhttps://scholarworks.harding.edu/pharmacy-facpub/14
https://scholarworks.harding.edu/pharmacy-facpub/14Tue, 19 Feb 2019 13:11:44 PST
Today's pharmacists are essential health care providers placed in more diverse environments than in the past. In contemporary practice, they need to possess knowledge and communication skills unprecedented in the history of pharmaceutical care. In many communities, the community pharmacist is spearheading wellness programs to assist patients with immunizations, diabetes, HIV/AIDS, and cholesterol screenings. The demographic composition of the United States is rapidly changing, indicating a pivotal shift of the minority population to majority. The increasing numbers of minority persons should give rise to a new generation of pharmacist leaders to create social and political changes throughout society. To produce the next generation of minority pharmacists and pharmacy educators, more students must be recruited into pharmaceutical programs. A solid investment in the promotion of diversity in pharmaceutical education is crucial to strengthen the pipeline and ensure the growth and enhancement of the pharmaceutical sciences for many years.
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Henry NorthCrystal structures of 2-meth­oxy­isoindoline-1,3-dione, 1,3-dioxoisoindolin-2-yl methyl carbonate and 1,3-dioxo-2,3-di­hydro-1H-benzo[de]isoquinolin-2-yl methyl carbonate: three anti­convulsant compoundshttps://scholarworks.harding.edu/pharmacy-facpub/13
https://scholarworks.harding.edu/pharmacy-facpub/13Tue, 19 Feb 2019 13:11:27 PST
The title compounds, C9H7NO3, (1), C10H7NO5, (2), and C14H9NO5, (3), are three potentially anti­convulsant compounds. Compounds (1) and (2) are isoindoline derivatives and (3) is an iso­quinoline derivative. Compounds (2) and (3) crystallize with two independent mol­ecules (A and B) in their asymmetric units. In all three cases, the isoindoline and benzoiso­quinoline moieties are planar [r.m.s. deviations are 0.021 Å for (1), 0.04 and 0.018 Å for (2), and 0.033 and 0.041 Å for (3)]. The substituents attached to the N atom are almost perpendicular to the mean planes of the heterocycles, with dihedral angles of 89.7 (3)° for the N—O—Cmeth­yl group in (1), 71.01 (4) and 80.00 (4)° for the N—O—C(=O)O—Cmeth­ylgroups in (2), and 75.62 (14) and 74.13 (4)° for the same groups in (3). In the crystal of (1), there are unusual inter­molecular C=O⋯C contacts of 2.794 (1) and 2.873 (1) Å present in mol­ecules A and B, respectively. There are also C—H⋯O hydrogen bonds and π–π inter­actions [inter-centroid distance = 3.407 (3) Å] present, forming slabs lying parallel to (001). In the crystal of (2), the A and B mol­ecules are linked by C—H⋯O hydrogen bonds, forming slabs parallel to (10-1), which are in turn linked via a number of π–π inter­actions [the most significant centroid–centroid distances are 3.4202 (7) and 3.5445 (7) Å], forming a three-dimensional structure. In the crystal of (3), the A and B mol­ecules are linked via C—H⋯O hydrogen bonds, forming a three-dimensional structure, which is consolidated by π–π inter­actions [the most significant inter-centroid distances are 3.575 (3) and 3.578 (3) Å].
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Fortune Ezemobi et al.Developing a practice site in the non-academic community hospital: A primer for pharmacy practice faculty membershttps://scholarworks.harding.edu/pharmacy-facpub/12
https://scholarworks.harding.edu/pharmacy-facpub/12Mon, 18 Feb 2019 17:31:38 PST
The need for quality advanced pharmacy practice experiences (APPEs) and clinical practice sites for pharmacy faculty in in-patient settings continues to increase with the expansion of colleges of pharmacy. Since the patient care model in non-academic community hospitals often differs from the traditional model in an academic institution, the development of a practice site and experiential education in this setting requires a strategic approach by the faculty member. This article was developed by three full-time pharmacy practice faculty at different colleges of pharmacy who were each tasked with developing a new part-time practice site at a non-academic community hospital. Included are strategies for establishing the site, overcoming barriers to the creation of an optimal practice environment, and keeping the momentum once the site has been established. The various roles of a faculty member in this setting and some of the advantages to practicing within a non-academic community hospital are also presented. As the landscape of pharmacy education continues to evolve, successful development and perspectives from these practice sites should be shared.
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Montgomery F. Williams et al.QTc Prolongation Associated with Psychotropics: Therapeutics Considerationshttps://scholarworks.harding.edu/pharmacy-facpub/11
https://scholarworks.harding.edu/pharmacy-facpub/11Mon, 18 Feb 2019 12:26:45 PST
This article focuses on the importance of QTc monitoring in patients receiving psychotropics, especially when multiple medications are prescribed.
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Megan B. McCorkle et al.Clinical Interpretation of Urine Drug Tests: What Clinicians Need to Know About Urine Drug Screenshttps://scholarworks.harding.edu/pharmacy-facpub/10
https://scholarworks.harding.edu/pharmacy-facpub/10Mon, 18 Feb 2019 12:26:28 PST
Urine drug testing is frequently used in clinical, employment, educational, and legal settings and misinterpretation of test results can result in significant adverse consequences for the individual who is being tested. Advances in drug testing technology combined with a rise in the number of novel misused substances present challenges to clinicians to appropriately interpret urine drug test results. Authors searched PubMed and Google Scholar to identify published literature written in English between 1946 and 2016, using urine drug test, screen, false-positive, false-negative, abuse, and individual drugs of abuse as key words. Cited references were also used to identify the relevant literature. In this report, we review technical information related to detection methods of urine drug tests that are commonly used and provide an overview of false-positive/false-negative data for commonly misused substances in the following categories: cannabinoids, central nervous system (CNS) depressants, CNS stimulants, hallucinogens, designer drugs, and herbal drugs of abuse. We also present brief discussions of alcohol and tricyclic antidepressants as related to urine drug tests, for completeness. The goal of this review was to provide a useful tool for clinicians when interpreting urine drug test results and making appropriate clinical decisions on the basis of the information presented.
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K E. Moeller et al.The Discovery of the MCH-1 Receptor Antagonist NGD-4715 for the Potential Treatment of Obesityhttps://scholarworks.harding.edu/pharmacy-facpub/9
https://scholarworks.harding.edu/pharmacy-facpub/9Mon, 18 Feb 2019 12:26:12 PST
For the first time, we disclose the medicinal chemistry efforts at Neurogen Corporation that led to the discovery of the clinical phase I compound NGD-4715 ( 7 ), a selective, brain penetrant, orally bioavailable melanin-concentrating hormone receptor 1 antagonist. We discuss the optimization of an arylpiperazine serendipitous hit in a high-throughput screening that led to the discovery of NDT 9522320 ( 10 ), a useful tool compound that enabled target validation in rat and dog feeding models. Subsequent medicinal chemistry design led to the bicyclic core of NGD-4715. We recount how we arrived at selecting NGD-4715 as a development candidate and summarize our clinical experience with it. A number of syntheses are presented, which were explored as a prelude to the highly optimized chemical process synthesis used to support the IND-enabling toxicology program and deliver clinical supplies for the phase I studies. We discuss the backup strategy that led to NGD-0589, as well as the discovery of further improved compounds.
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J. Tarrant et al.Chapel - April 28, 2017https://scholarworks.harding.edu/chapel/224
https://scholarworks.harding.edu/chapel/224Mon, 11 Feb 2019 19:45:35 PST
Program: Salute to Seniors Song Leader: Briley Ewing Prayer led by: Chancelor Ganus
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Chapel - April 27, 2017https://scholarworks.harding.edu/chapel/223
https://scholarworks.harding.edu/chapel/223Mon, 11 Feb 2019 19:45:29 PST
Program: Petit Jean Chapel Main Speaker: Garret Howard Song Leader: Joshua Johnson Prayer led by: Cole Custer
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Chapel - April 26, 2017https://scholarworks.harding.edu/chapel/222
https://scholarworks.harding.edu/chapel/222Mon, 11 Feb 2019 19:45:21 PST
Program: Alpha Chi Song Leader: Glen Metheny Prayer led by: Jim Shelton
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Chapel - April 25, 2017https://scholarworks.harding.edu/chapel/221
https://scholarworks.harding.edu/chapel/221Mon, 11 Feb 2019 19:45:13 PST
Program: Student Association Pass the Gavel Main Speaker: Daniel Evans Song Leader: Parker Pruitt Prayer led by: Kurk McDaniel
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Chapel - April 24, 2017https://scholarworks.harding.edu/chapel/220
https://scholarworks.harding.edu/chapel/220Mon, 11 Feb 2019 19:45:06 PST
Program: Summer Missions Send Off Main Speaker: Ken Graves Song Leader: Daniel Norwood, Zach Cowdery Prayer led by: Zach Cowdery Devotional led by: Zach Cowdery
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Chapel - April 21, 2017https://scholarworks.harding.edu/chapel/219
https://scholarworks.harding.edu/chapel/219Mon, 11 Feb 2019 19:44:59 PST
Program: Senior Speeches Main Speaker: Danielle Henslee, Manual Barrantes Duarte Song Leader: Hunter Hackworth Prayer led by: Jared Mannon Devotional led by: Logan Stark
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Chapel - April 20, 2017https://scholarworks.harding.edu/chapel/218
https://scholarworks.harding.edu/chapel/218Mon, 11 Feb 2019 19:44:52 PST
Program: Senior Speeches Main Speaker: Meg Dono, Austin Balblin Song Leader: Harley Halliburton Prayer led by: Ken Hammoth
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Chapel - April 19, 2017https://scholarworks.harding.edu/chapel/217
https://scholarworks.harding.edu/chapel/217Mon, 11 Feb 2019 19:44:44 PST
Program: Senior Speeches Main Speaker: Emma Reese, Scott Record Song Leader: Jonathan Bentley Prayer led by: Neale Zeringue Devotional led by: Taylor Hodges
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Chapel - April 18, 2017https://scholarworks.harding.edu/chapel/216
https://scholarworks.harding.edu/chapel/216Mon, 11 Feb 2019 19:44:37 PST
Program: Cross Eyed Main Speaker: Ryan Turley Song Leader: Garison Hendrix Prayer led by: Ryan Simpson
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Chapel - April 17, 2017https://scholarworks.harding.edu/chapel/215
https://scholarworks.harding.edu/chapel/215Mon, 11 Feb 2019 19:44:29 PST
Main Speaker: Heath Carpenter Song Leader: Zach Cowdery Prayer led by: Connor Botes
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Chapel - April 14, 2017https://scholarworks.harding.edu/chapel/214
https://scholarworks.harding.edu/chapel/214Mon, 11 Feb 2019 19:44:22 PST
Main Speaker: Ross Cochran Song Leader: Terry Davis Prayer led by: Aundrey Fluewellen
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Chapel - April 13, 2017https://scholarworks.harding.edu/chapel/213
https://scholarworks.harding.edu/chapel/213Mon, 11 Feb 2019 19:44:14 PST
Program: Bison Days Main Speaker: Jason White Song Leader: Tyler Mayo Prayer led by: Casey Phillips
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Chapel - April 12, 2017https://scholarworks.harding.edu/chapel/212
https://scholarworks.harding.edu/chapel/212Mon, 11 Feb 2019 19:44:07 PST
Program: Significant Others Main Speaker: Monte Cox Song Leader: Joe Brumfield Prayer led by: Silas Hall
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Chapel - April 11, 2017https://scholarworks.harding.edu/chapel/211
https://scholarworks.harding.edu/chapel/211Mon, 11 Feb 2019 19:43:59 PST
Main Speaker: Nick Bryce Song Leader: Daniel Smith Prayer led by: Alex Barns
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