Created by Amy Sherman-Palladino, Brosnahan plays the titular Mrs. Maisel, a New York City housewife whose life takes an unexpectedly comedic turn after she learns the truth about her husband. Sherman-Palladino’s breakthrough TV show “Gilmore Girls” was only nominated for a single Golden Globe — Best Comedy Actress for Lauren Graham in 2002 — so a victory for “The Marvelous Mrs. Maisel” would be a long time coming for the well-known auteur.

The Golden Globes are notorious for rewarding brand new shows, and nothing is more hot off the presses than “The Marvelous Mrs. Maisel,” which just streamed on November 29. However, there is one other freshman show in the running for Best Comedy Series: Showtime’s “SMILF.” Created by and starring Frankie Shaw, “SMILF” centers on the life of a single mother who’s trying to get her groove back. It fits the tone and style of former Golden Globe champs “Girls” and “Transparent,” so it could be right up their alley.

Gold Derby’s predictions for Best Comedy Series favor “The Marvelous Mrs. Maisel” to win with leading 1/4 odds, while “SMILF” is tied for second place at 16/1 odds alongside Netflix’s “Master of None.” The other two comedies come from the broadcast network: ABC’s “Will & Grace” at 18/1 odds and ABC’s “Black-ish” with 33/1 odds. See more Golden Globes TV odds and rankings.

Be sure to make your Golden Globe predictions so that Hollywood insiders can see how their TV shows and performers are faring in our odds. You can keep changing your predictions until just before winners are announced on January 7. And join in the fierce debate over the 2018 Golden Globes taking place right now with Hollywood insiders in our TV forums. Read more Gold Derby entertainment news.