The responses of DNA origami conformation to UV radiation of different wavelengths and doses are investigated. Short- and medium-wavelength UV light can cause photo-lesions in DNA origami. At moderate doses, the lesions do not cause any visible defects in the origami, nor do they significantly affect the hybridization capability. Instead, they help relieve the internal stress in the origami structure and restore it to the designed conformation. At high doses, staple dissociation increases which causes structural disintegration. Long-wavelength UV does not show any effect on origami conformation by itself. We show that this UV range can be used in conjunction with photoactive molecules for photo-reconfiguration, while avoiding any damage to the DNA structures.

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BibTeX @article{Chen2017,author={Chen, Haorong and Li, Ruixin and Li, Shiming and Andréasson, Joakim and Choi, Jong Hyun},title={Conformational effects of UV light on DNA origami},journal={Journal of the American Chemical Society},issn={00027863},volume={139},issue={4},pages={1380-1383},abstract={The responses of DNA origami conformation to UV radiation of different wavelengths and doses are investigated. Short- and medium-wavelength UV light can cause photo-lesions in DNA origami. At moderate doses, the lesions do not cause any visible defects in the origami, nor do they significantly affect the hybridization capability. Instead, they help relieve the internal stress in the origami structure and restore it to the designed conformation. At high doses, staple dissociation increases which causes structural disintegration. Long-wavelength UV does not show any effect on origami conformation by itself. We show that this UV range can be used in conjunction with photoactive molecules for photo-reconfiguration, while avoiding any damage to the DNA structures.},year={2017},}

RefWorks RT Journal ArticleSR ElectronicID 248371A1 Chen, HaorongA1 Li, RuixinA1 Li, ShimingA1 Andréasson, JoakimA1 Choi, Jong HyunT1 Conformational effects of UV light on DNA origamiYR 2017JF Journal of the American Chemical SocietySN 00027863VO 139IS 4SP 1380OP 1383AB The responses of DNA origami conformation to UV radiation of different wavelengths and doses are investigated. Short- and medium-wavelength UV light can cause photo-lesions in DNA origami. At moderate doses, the lesions do not cause any visible defects in the origami, nor do they significantly affect the hybridization capability. Instead, they help relieve the internal stress in the origami structure and restore it to the designed conformation. At high doses, staple dissociation increases which causes structural disintegration. Long-wavelength UV does not show any effect on origami conformation by itself. We show that this UV range can be used in conjunction with photoactive molecules for photo-reconfiguration, while avoiding any damage to the DNA structures.LA engDO 10.1021/jacs.6b10821LK http://dx.doi.org/10.1021/jacs.6b10821OL 30