Commercialization of Generics Impacts Adverse Event Rates

WEDNESDAY, Oct. 4, 2017 (HealthDay News) — Immediate or delayed differences in adverse event rates were seen after generic commercialization of three antihypertensive drugs, according to a study published online Oct. 3 in Circulation: Cardiovascular Quality and Outcomes.

The researchers found that before and after generic commercialization, for all users, there was a monthly mean rate of 100 adverse events for 1,000 angiotensin II receptor blockers users. The month of generic commercialization, there was an increase in the rates of adverse events among generic users of losartan, valsartan, and candesartan of 8, 11.7, and 14 percent, respectively (difference of proportions versus brand name, 7.5 [95 percent confidence interval, -0.9 to 15.9 percent], 17.1 [95 percent confidence interval, 9.9 to 24.3 percent], and 16.6 percent [95 percent confidence interval, 7.9 to 25.3 percent], respectively). At &#8804;one year after generic commercialization, the monthly trend of adverse events was affected for generic versus brand-name losartan users only (difference of proportions, 2 percent). Results were similar in sensitivity analyses.