To identify the pathways of LDL uptake, scientists performed a genome-wide RNAi screen in endothelial cells and cross-referenced with genome-wide association studies-data sets. [Nat Commun]
Full Article

FSH-follicle-stimulation hormone receptor (FSHR) signaling was shown to promote human umbilical vein endothelial cells (HUVEC) angiogenesis and thereafter suggested to have an influential role in pregnancy. Scientists revisited the expression and functionality of FSHR in HUVECs angiogenesis, and were unable to reproduce the FSHR expression in human umbilical cord, HUVECs or immortalized HUVECs. [Sci Rep]
Full Article

Investigators described the development of ‘skin-on-a-chip’ to mimic the structures and functional responses of the human skin. The proposed model consists of three layers, on which epidermal, dermal and endothelial components originated from human, were cultured. [Sci Rep]
Full Article

Researchers identified a subpopulation of chemokine receptor (CCR5) expressing endothelial cells in the breast tumor microenvironment, and described a clinical correlation between vascular expression of CCR5 and invasive tumor grade. [Oncotarget]
Full Article

Scientists aimed to understand the role of autophagy and its regulatory mechanisms by treating human umbilical vein endothelial cells with salidroside under oxidative stress. [Mol Cell Biochem]
Abstract

Three decades ago a revolutionary idea ascribing to dysfunctional endothelia some manifestations of diabetes was born, the Steno hypothesis. The author briefly outlines the accomplishments made in the past 15 years to buttress this hypothesis. [Am J Physiol Renal Physiol]
Abstract

Visit our
reviews
page to see a complete list of reviews in
the endothelial cell research field.

Athenex, Inc. announced a new collaboration to conduct a Phase Ib study that will evaluate the safety and tolerability of oraxol, Athenex’s oral form of paclitaxel, in combination with Eli Lilly and Company’s CYRAMZA® (ramucirumab), a vascular endothelial growth factor receptor 2 antagonist, in patients with advanced gastric and esophageal cancer. [Athenex, Inc.]
Press Release

Amgen and Allergan plc. announced the submission of a Biologics License Application to the U.S. Food and Drug Administration for ABP 215, a biosimilar candidate to Avastin® (bevacizumab). ABP 215 is a biosimilar candidate to bevacizumab, a recombinant immunoglobulin G1 monoclonal antibody that binds to vascular endothelial growth factor (VEGF) and inhibits the interaction of VEGF with its receptors, VEGF receptor-1 and VEGF receptor-2, thus inhibiting establishment of new blood vessels necessary for the maintenance and growth of solid tumors. [Amgen Inc.]
Press Release

UK scientists have welcomed a surprise government promise to invest an extra £2 billion (US$2.5 billion) per year into research and development by 2020 – although details of the pledge will not be made clear for at least another two days. [Nature News]
Editorial

“Painful, bizarre, and wasteful experiments.” Buying dogs “just to cut them apart … and kill them.” These statements might sound like the rhetoric used by extreme animal rights groups, but they come from White Coat Waste—a new, unlikely coalition of fiscal conservatives and liberal activists that aims to end federal funding for research involving dogs and other animals by targeting people’s pocketbooks in addition to their heartstrings. [ScienceInsider]
Editorial

Brazil’s science budget has shrunk by more than 40% in the past three years. But researchers are now trying to escape an even worse crisis: federal science spending could be frozen at its current low level for the next two decades, under a constitutional amendment to cap public spending to only inflation-level rises. [Nature News]
Editorial

Ever since June’s Brexit referendum, scientists have fretted about the uncertainty caused for non-British EU nationals, who have been left unsure what their employment rights may be in a few years’ time. There are around 31,000 such researchers in the United Kingdom, according to a Royal Society estimate, and they make up about 15% of UK universities’ academic staff. [Nature News]
Editorial