You can most certainly manage your iPod with Mint. I recommend Hipo for this task. Hipo is an application that allows you to manage the data of your iPod, Hipo is written in C# using Mono, GTK#, the cute ipod-sharp library and for tag editing it uses taglib-sharp.

Hipo is NOT a music playback software, for that you can use Banshee, Rhythmbox or Muine. If you prefer KDE, then Amarok is your answer. Learn more about Hipo here:http://www.gnome.org/projects/hipo/