Gambit's wife arrives and informs him of trouble with the Assassin's Guild in New Orleans; The X-Men travel there only to find the Assassins have been infected by the Brood; Ghost Rider, who preceded them there, has also been infected by the evil aliens; After breaking Ghost Rider free of his alien parasite, he and the X-Men take on the Brood and their Queen in trying to save the remains of the Thieves Guild from certain death.