About 30 years ago there was a TV program where the researchers made an injection into the brown cell area of a subject and noted the increased heat output, when asked what the injection was they refused to name it as it was too controversial but it has since been apparent that it was nicotine as it is well known that smoking causes weight loss.When I was a boy midwives recommended mothers to smoke to reduce the size of their babies and reduce the stress of giving birth!

I fail to see how pharmacological-alteration of the circadian rhythm could have any appreciable effects on obesity-prevention.

Still don't get it.....

"Targeting this brake on BAT function could provide a way to increase the daily BAT consumption of glucose and fat stores in a safer and more specific manner than through the more classic, ubiquitous pathway of adrenergic signaling. Furthermore, preventing the BAT clock from actively suppressing calorie-burning at night could potentially increase BAT output without an uncomfortable or dangerous elevation in body temperature that is perhaps more likely with strategies that enhance BAT activity beyond its endogenous maximal capacity. However, whether or not the difference in energy balance from unlocking the circadian inhibition of BAT would be significant enough to mitigate the effects of metabolic syndrome is as yet undetermined (91)."

*If targeting BAT-function through the alteration of circadian rhythm is their approach.... they're not going to achieve any degree of efficacy in terms of obesity-prevention*

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