Lysosomal Degradation of Glycoproteins and Glycosaminoglycans

Abstract

The catabolism of brain glycoconjugates is a complex process involving the interaction of endoglycosidases, exoglycosidases, and proteinases, as summarized in Table 1. Lysosomal catabolism of these glycoconjugates further requires the delivery of both the catabolic enzymes and their substrates to this organelle, and the maintenance of a functional milieu having the proper acidic pH and complement of cofactors (e.g., cations) to facilitate efficient catabolism.

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