This approach is noteworthy—in the fashionable world of CNVs, we must not forget our previous SNP findings. Modeling epistasis between genes should be a priority, yet there are very few approaches and publications in this arena (compared to the number of publication on single gene effects). It is also nice to see that data replicate, and that we see the usual suspects, including PDE4B, RELN, ERBB4, DISC1, and NRG1.