Selected Publications

CELL BIOLOGY: Fraternal twins – A popular route for protein translocation across cellular membranes is through the Sec channel. The channel seems to function by forming a dimer of two identical units, where each serves a distinct role … News & Views in Nature, 446, 741-743 (2007)

Nanodiscs unravel the interaction between the SecYEG channel and its cytosolic partner SecA – We report here the reconstitution of a single SecYEG complex into nano-scale lipid bilayers, termed Nanodiscs. These water-soluble particles … EMBO J. 26, 1995-2004 (2007)

Deregulation of the SecYEG translocation channel upon removal of the plug domain – Previous studies have shown that the SecY plug is displaced from the center of the SecYEG channel during polypeptide translocation. The structural and functional consequences of the deletion of the plug are now examined … J Biol Chem. 282, 1281-1287 (2006). [abstract]

Preprotein translocation through the Sec translocon in prokaryotes. Almost 30% of the polypeptide chains synthesized by living cells are routed to extracellular or membrane locations. Most of these polypeptides are translocated via the Sec pathway … In Protein Movement Across Membranes. Ed. J. Eichler, Landes Biosciences Eds (2005)

Break on through to the other side–the Sec translocon. Proteins designated to reside outside the cytoplasm must, at some point, traverse a lipid-based membrane … Trends Biochem. Sci. 29, 221-223 (2004) [abstract]

The PrlA and PrlG phenotypes are caused by a loosened association among the translocase SecYEG subunits. prlA mutations in the gene encoding the SecY subunit of the membrane domain of the Escherichia coli preprotein translocase confer many phenotypes: …EMBO J, 18, 3263-3270 (1999) [abstract]

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