Welcome

Dr. Aytes´s laboratory aims at uncovering new mechanisms driving cancer progression and metastasis and to elucidate how these mechanisms contribute to the emergence of therapeutic resistance. The lab´s main focus is on prostate cancer, the second leading cause of cancer death in men. We utilize genetically-engineered mice (GEM) to model relevant molecular alterations, thereby recapitulating the progression pathway observed in human prostate cancer. In addition, our lab utilizes gene regulatory network-based approaches to conduct cross-species studies to identify actionable targets that can be validated in preclinical models. More>>