Pomi-T® Safety Information

The individual foods within Pomi-T® are known to be safe if concentrated and combined, most men in the Pomi-T trial had no side effect at all and some even reported improved well being such as bowel function but there are some potential interactions and possible side effects:

Pomegranate

Like many fruit juices, pomegranate is potentially a weak inhibitor of cytochrome P450 (CYP2C9).
There is, therefore, a small potential risk of reducing the metabolism, and thereby increasing serum levels, of warfarin and anti-hypertensives such as captopril, ramipril or anti-consulsants such a carbimazole (for more details see www.rxlist.com).
Individuals on warfarin or these blood pressure tablets are not excluded from taking Pomi-t and no adverse changes in blood pressure or INR were reported in the Pomi-T study but it may be advisable to repeat a blood pressure and an INR test within two weeks of starting.

Tea

Millions of people consume tea daily with no adverse effects. Green tea can cause discolouration of the teeth – this should not be a problem unless Pomi-T is chewed.
In very high doses, patients who took 6 kg/day, experienced mild to moderate nausea, vomiting, abdominal pain, diarrohea, agitation, restlessness, insomnia and tremors [Jatoi 2003, Pisters 2001].
None of these effects were reported in the Pomi-t study.

Broccoli

Very high intakes of cruciferous vegetables, have been found to slightly reduce thyroid activity in animals (Fenwick et al 1983). There has been one case of an elderly woman developing hypothyroidism following consumption of over 1.0 kg/day of raw pak choy for several months [Chu M et al 2010].

Curcumin (Turmeric)

Curcumin is recognised as safe by the FDA as a food additive. Adverse effects have not been reported in humans even taking 8 g/day [Chung 2001].
Curcumin mildly inhibits platelet aggregation in animal studies suggesting a potential to increase the risk of bleeding in people taking anti-platelet medication [Shah 1999] but no reports have been found in humans including those in the Pomi-T study.

Interaction with Chemotherapy

A laboratory experiences using cells in petri dishes suggest that high doses of polyphenols can have anti-oxidant activity can potentially reduce the action of chemotherapy [Somasundaram 2002]. This has not actually been substantiated in humans and there are ongoing studies registered with the National Cancer Institute to try to find out with they can reduce side effects of chemotherapy without reducing the effect.
In view of this potential interaction, until this issue has been scientifically resolved, taking regular Pomi-T® during chemotherapy is best avoided although there is no contract indication immediately afterward. There is no evidence that turmeric, broccoli, pomegranate or green tea adversely affects pregnancy, although the safety of these supplements in pregnancy and lactation has not been established.