Previous GeneCards Identifiers for ACR Gene

Summaries for ACR Gene

Entrez Gene Summary for ACR Gene

Acrosin is the major proteinase present in the acrosome of mature spermatozoa. It is a typical serine proteinase with trypsin-like specificity. It is stored in the acrosome in its precursor form, proacrosin. The active enzyme functions in the lysis of the zona pellucida, thus facilitating penetration of the sperm through the innermost glycoprotein layers of the ovum. The mRNA for proacrosin is synthesized only in the postmeiotic stages of spermatogenesis. In humans proacrosin first appears in the haploid spermatids. [provided by RefSeq, Jul 2008]

GeneCards Summary for ACR Gene

ACR (Acrosin) is a Protein Coding gene.
Diseases associated with ACR include Spermatogenic Failure 6 and Male Infertility.
Among its related pathways are Fertilization.
GO annotations related to this gene include serine-type endopeptidase activity and drug binding.
An important paralog of this gene is TMPRSS9.