Before Using

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of quinapril and hydrochlorothiazide combination in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of quinapril and hydrochlorothiazide combination in the elderly. However, elderly patients are more likely to have age-related heart, kidney, or liver problems, which may require caution and an adjustment in the dose for patients receiving quinapril and hydrochlorothiazide combination.

Pregnancy

Information about this quinapril-and-hydrochlorothiazide-oral-route

Pregnancy Category

Explanation

All Trimesters

D

Studies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy in a life threatening situation or a serious disease, may outweigh the potential risk.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

Aliskiren

Dofetilide

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Acetyldigoxin

Alteplase, Recombinant

Amiloride

Arsenic Trioxide

Azathioprine

Azilsartan

Candesartan Cilexetil

Canrenoate

Cyclophosphamide

Deslanoside

Digitalis

Digitoxin

Digoxin

Droperidol

Eplerenone

Eprosartan

Flecainide

Insulin Degludec

Irbesartan

Ketanserin

Levomethadyl

Lithium

Losartan

Methotrexate

Metildigoxin

Olmesartan Medoxomil

Ouabain

Potassium

Proscillaridin

Sotalol

Spironolactone

Telmisartan

Triamterene

Trimethoprim

Valsartan

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Aceclofenac

Acemetacin

Alacepril

Amtolmetin Guacil

Aspirin

Azosemide

Bemetizide

Benazepril

Bendroflumethiazide

Benzthiazide

Bepridil

Bromfenac

Bufexamac

Bumetanide

Bupivacaine

Bupivacaine Liposome

Buthiazide

Capsaicin

Captopril

Carbamazepine

Celecoxib

Chlorothiazide

Chlorpropamide

Chlorthalidone

Cholestyramine

Choline Salicylate

Cilazapril

Clonixin

Clopamide

Cyclopenthiazide

Cyclothiazide

Delapril

Dexibuprofen

Dexketoprofen

Diclofenac

Diflunisal

Dipyrone

Enalaprilat

Enalapril Maleate

Ethacrynic Acid

Etodolac

Etofenamate

Etoricoxib

Felbinac

Fenoprofen

Fepradinol

Feprazone

Floctafenine

Flufenamic Acid

Flurbiprofen

Fosinopril

Furosemide

Ginkgo

Glipizide

Gold Sodium Thiomalate

Gossypol

Hydrochlorothiazide

Hydroflumethiazide

Ibuprofen

Ibuprofen Lysine

Imidapril

Indapamide

Indomethacin

Ketoprofen

Ketorolac

Licorice

Lisinopril

Lithium

Lornoxicam

Loxoprofen

Lumiracoxib

Meclofenamate

Mefenamic Acid

Meloxicam

Methyclothiazide

Metolazone

Moexipril

Morniflumate

Nabumetone

Naproxen

Nepafenac

Nesiritide

Niflumic Acid

Nimesulide

Oxaprozin

Oxyphenbutazone

Parecoxib

Pentopril

Perindopril

Phenylbutazone

Piketoprofen

Piretanide

Piroxicam

Polythiazide

Pranoprofen

Proglumetacin

Propyphenazone

Proquazone

Quinapril

Quinethazone

Ramipril

Rofecoxib

Salicylic Acid

Salsalate

Sodium Salicylate

Spirapril

Sulindac

Temocapril

Tenoxicam

Tiaprofenic Acid

Tolfenamic Acid

Tolmetin

Topiramate

Torsemide

Trandolapril

Trichlormethiazide

Valdecoxib

Xipamide

Zofenopril

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

Angioedema (swelling of the face, lips, tongue, throat, arms, or legs), history of—May increase the risk of this condition occurring again.

Anuria (not able to pass urine) or

Diabetic patients or those with kidney problems who are also taking aliskiren (Tekturna®) or

Sulfa drug allergy (eg, sulfamethoxazole, Bactrim®, Septra®)—Should not be used in patients with these conditions.