Properties

Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.

Storage bufferPreservative: 0.09% Sodium Azide
Constituents: PBS

Concentration information loading...

PurityProtein G purified

Purification notesThis antibody was purified through a protein G column and eluted out with both high and low pH buffers. It was neutralized immediately after elution, followed by dialysis against PBS.

Target

FunctionDOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3.

Post-translationalmodificationsConstitutively tyrosine-phosphorylated.Phosphorylated on tyrosine residues by the insulin receptor kinase. Results in the negative regulation of the insulin signaling pathway.

ab37835, at 1/1000 dilution, staining DOK1 in Human hepatocarcinoma by Immunohistochemistry, Formalin-fixed, Paraffin-embedded tissue. The primary antibody was peroxidase-conjugated to the secondary antibody, followed by AEC staining.

References for Anti-DOK1 antibody (ab37835)

ab37835
has not yet been referenced specifically in any publications.

Publishing research using ab37835? Please let us know so that we can cite the reference in this datasheet.