Friday, 13 February 2015

Broccoli soup at school – washed down with a little grapefruit juice

A growing
number of readers have discovered the remarkable effects of a specific preparation
of broccoli sprout powder.It was my
suggested method to match the Sulforaphane, made in the lab at Johns Hopkins,
and recently trialed with great results in young adults with autism.

I did
mention to therapists working with Monty, aged 11 with ASD, what a surprise
there would be at the local special school if they served up some extra-potent
broccoli soup for lunch one day. There
would be some very bemused teachers and parents. It would also be the world's cheapest randomized trial on 100 people and the fastest. (you would just have to note down who actually ate the soup, but I think it would be obvious later)

Since
another reader stumbled upon the anti-oxidant capability of grapefruit juice
the other day, I would add some of that to the school lunch. Preferably pink grapefruit, since they also would
have a dose of lycopene, another potent antioxidant.

As fate
would have it, a trial is underway with a jar of the aforementioned broccoli
powder. It is not at
the local special school, but at a private center for speech & behavioral therapy.

A reader of this blog has told someone else, who
then tried it on their child and now someone else has bought a jar to try on the
children at the center.

Of course,
in a litigious country, nobody would dream of doing this; but in some countries,
common sense still prevails.

I do hope
the center keeps a note of who tried it and what the effects were, so we can
have some statistics. The good thing is
that because it is so fast-acting, the therapist will observe the effects
unfolding within the very same session.

Since the
main effects are on mood and speech, a speech therapist is probably the best
person to observe and quantify the effect.

In the kind
of children who attend such centers, where autism is a disability rather than a
difference, I think the response rate with be really high. I would guess 70+%. If they want to write up a report, I will be
delighted to post it on this blog.

14 comments:

That school is fantastic! Bravo!But, considering your PolyPill, I must add this:There are several studies about grapefruit and statin interaction, and recent ones suggest that moderate grapefruit consumption can be compatible with taking lovastatin and other statin drugs.Even so, I wouldn't mix them together, Peter.

We also want endorse the positive effects of broccoli sprouts in terms of improving language / sociability / irratibilty. Together with pharmaNac we have been able to get our child off Risperdal (thank God). To date, this combo has demonstrated to be the most effective.

We still believe the I/E ratio in our child is unbalanced. He still demonstrates high anxiety. We would like to compliment the above with either low dose Clonazepam or Buteminide. We're unsure if our doc will prescribe Buteminide.

Peter, any thoughts on how you can separate .025mg Clonazepam from 2mg tablets. Our doc might not prescribe Buteminide and my wife already takes Clonazepam.

You can crush a clonazepam tablet, place in a 100ml medicine bottle, add water and then measure out a precise dose using a syringe. Since it forms a suspension, you need to shake very well each time.

Print out the clinical trial of bumetanide in autism and give it to your doctor, this might help.

Another way to modulate GABAa is via the neurosteroid binding site. One modulator is allopregnanolone. This is produced by pregnenalone and progesterone. I will add a post on this very soon. You can buy progesterone cream and some people with Asperger's/ADHD are using it to reduce anxiety. You just rub it on your skin. There may be better methods for long term use, but for a trial lasting a few days I do not see a big risk.

I keep it in the fridge. Due to the long half life, it will take about 3 days to reach a stable level, so do not expect anything visible straight away.

I would give 1mg of bumetanide at breakfast and 1 mg again in late afternoon. I will cause extra visits to the WC, so you need to anticipate this. You also need to make up the loss in fluid, ie drink more water. The effect takes a while to be visible, In would allow at least 2 weeks. The researchers suggest 2 months. To avoid any problems with low potassium, eat an extra banana, drink orange juice or add a potassium supplement.

There are lots of progesterone creams for women, and even men. You can buy in Australia from BIOVEA, but they are out of stock. I expect there will be other suppliers as well.

Interesting results on antinflammatory effects of sulforaphane, which (if this still holds true in vivo) could easily be related to its effects in autism http://www.fasebj.org/content/28/1_Supplement/830.5.short

Could you please advise on which B.Sprout powder or a source in the US for Sulforaphane? We have had the most success with Bumetanide and Clonidine, Probiotics in high doses and Multivit supp. I enjoy following your blog. Very useful.

Hi Veronica. As Peter mentioned below, how did you obtain your Bumetanide? I am trying to convince my son's psychiatrist to try it but have not been successful. Interestingly, she prescribed Clonidine for my son for hyperactivity, which is just as "off label" as Bumetanide.

Any advice or tips on how you convinced your physician to prescribe it would be much appreciated.

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By Agnieszka Wroczyńska, MD, PhD, Medical University of Gdansk, Poland In June 2014 my son with severe autism ...

About this Blog

This blog is mainly a review of the science behind autism, looking for pointers to effective treatments for classic autism.The first treatment, Bumetanide, I stumbled upon before starting this blog.The last treatment, tiny doses of Clonazepam, came from a recent paper, highlighted by a regular follower of this blog.You do need some basic scientific knowledge, but putting our minds together, we can make our own medical advances; so all comments and case histories are very welcome.

If your interest is regressive autism, very likely the cause is mitochondrial disease. Classic autism therapies may well be ineffective. Mitochondrial disease can be diagnosed and treated.

Quack-free zone - Science only

About Me

I am an independent researcher, trawling through the scientific literature and doing some experiments along the way. I am not a doctor. I do have a Master's degree from a top science-only university and another one from a top business school. More relevant is my motivation.

I am developing a novel drug therapy, the Autism Polypill, to treat classic early-onset autism, since this is the type that affects my son. His type of autism is characterized by autistic behaviours, pollen allergy, asthma, some SIB, high serotonin, high cholesterol, high euthyroid, high IGF-1, but without seizures, GI problems, food intolerance or severe MR. I think that ADHD and Asperger's are likely to be very mild forms of this phenotype of autism. Many other types of "autism" are entirely different. As this blog shows, at least classic autism is treatable using today's drugs.