Xenopus laevis Protocadherin 8 (PCDH8) interaction partners

Because PAPC and C-cadherin do not directly interact nor form a joint complex with Fz7, Wnt-11 triggers formation of two distinct complexes that act in parallel to reduce cell adhesion by hampering clustering of C-cadherin.

Human Protocadherin 8 (PCDH8) interaction partners

PCDH8 methylation may be associated with tumor progression and poor prognosis in non-muscle invasive bladder cancer.

PCDH8 methylation may be a useful biomarker to predict the progression of clear cell renal cell carcinoma (show MOK Antibodies).

Loss of the PCDH8 gene is one of the probable causes of psychomotor delay in RB1 (show RB1 Antibodies)-deleted patients.

study demonstrates the epigenetic inactivation of PCDH8 by promoter methylation and its tumor suppressor function in gastric cancer

These results suggest that any contribution of PCDH8 polymorphisms to schizophrenia susceptibility is likely to be weak, although the existence of rare variations of stronger effect cannot be excluded.

Mouse (Murine) Protocadherin 8 (PCDH8) interaction partners

Protocadherin 8 (PCDH8) Antigen Profile

Protein Summary

This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The gene encodes an integral membrane protein that is thought to function in cell adhesion in a CNS-specific manner. Unlike classical cadherins, which are generally encoded by 15-17 exons, this gene includes only 3 exons. Notable is the large first exon encoding the extracellular region, including 6 cadherin domains and a transmembrane region. Alternative splicing yields isoforms with unique cytoplasmic tails.