New York Giants quarterback Eli Manning has had a tough time this season. How will he fare against the Philadelphia Eagles? Photograph: Jason Szenes/EPA

You know it has been a tough round in the Pick Six competition when nobody calls all six games correctly. That was the case last week, as the Colts' surprising win over Denver scuppered what few prospects there were for a full house. Indeed, if you found yourself looking mournfully at your score on Tuesday and wondering how you could get it all so wrong, then please rest assured that you were in good company; more people got zero last week than even managed five out of six.

Still, onwards and upwards. Six teams are enjoying their bye this weekend, meaning there were only 12 games left to choose from. I'll get to the ones that I have selected in just a second, but first a quick reminder that you can follow all the early games with our NFL Clockwatch live blog on Sunday from 1pm ET/6pm BST. And then, of course, we will wrap up the weekend on Tuesday in our Five Things We Learned blog.

Until then, here are this week's games:

Dallas Cowboys @ Detroit Lions (Sunday 1pm ET/6pm BST)

Dez Bryant caused a fuss this week when he responded to a question about his Lions counterpart Calvin Johnson by saying that: "I believe I can do whatever he can do". He subsequently denied that he was making comparisons, telling reporters in Detroit that he was simply trying to illustrate his confidence in his own abilities, but you can be sure that those two will be the centre of attention this Sunday. Both should see plenty of action in a match-up between two of the league's better passing offenses, and two of its worst pass defenses. This ought to be a shoot-out, and as such both teams need to do good jobs of keeping their quarterbacks upright. Detroit have given up just nine sacks of Matthew Stafford all year – and five of those came in the game that Megatron missed.

Lions to win

New York Giants @ Philadelphia Eagles (Sunday 1pm ET/6pm BST)

The Giants finally picked up their first win of the season on Monday night, edging a hideous match-up against the Minnesota Vikings. Could they make it two in a row by beating a Philadelphia team that has lost all of its last nine home games? At time of writing we do not know for certain who will be starting at quarterback for Philadelphia, after Chip Kelly refused to give a clear answer on Thursday, but Michael Vick has been practicing all week and would appear to be close to coming back from the hamstring injury that has kept him out since these two last met. My instinct is that he will play. If so, I think the Giants can help the Eagles to remember how to win in Philly.

Eagles to win

Miami Dolphins @ New England Patriots (Sunday 1pm ET/6pm BST)

The AFC East continues to perplex. After defeating the Saints without Rob Gronkowski in their line-up, the Patriots contrived to lose to the Jets despite having him back in a starring role. Miami, meanwhile, have followed up a 3-0 start by falling to three consecutive defeats. New England's injuries on defense are taking their toll, and the Dolphins' task will look a lot more achievable should cornerback Aqib Talib miss out once again. But Tom Brady is 10-1 at home against Miami in his career. I say he gets the job done.

Patriots to win

New York Jets @ Cincinnati Bengals (Sunday 4.05pm ET/9.05pm BST)

It might be time to start taking both of these teams seriously. Cincinnati have quietly built a two-game lead in the AFC North, and look like a very good bet to win the division. The Jets, meanwhile, are an improving concern. Rookie quarterback Geno Smith still has plenty to learn, but has now led four winning drives in either the fourth quarter or overtime. His team's fourth-ranked defense will make life difficult for the Bengals, whose lack of offensive balance remains a concern, but I am still going with the home team.

Bengals to win

Pittsburgh Steelers @ Oakland Raiders (Sunday 4.05pm ET/9.05pm BST)

Both of these teams are fighting to keep their seasons alive, though the Steelers have been doing a rather better job of it lately. Over the last two weeks Pittsburgh's defense has finally started to function at something close to the levels we are accustomed to, while the emergence of Le'Veon Bell at running back has eased the pressure on quarterback Ben Roethlisberger. But are they really playing well enough to win three in a row? Oakland are certainly not the most daunting opponents, but they have still won two games this season. They will also be well rested after a week off, although that is a double-edged sword; Oakland have lost all of their last 10 games coming off a bye. Nevertheless, I like them to take this one.

Raiders to win

Atlanta Falcons @ Arizona Cardinals (Sunday 4.25pm ET/9.25pm BST)

Few people would have imagined before the season began that Arizona would come into this match-up with a better record than their opponents. The Cardinals are hardly setting the league alight at 3-4 but given their low preseason expectations and a number of injuries on defense, they have been surprisingly competitive. Atlanta, by contrast, have been knocked way off their expected course by the losses of Julio Jones, Roddy White and Steven Jackson. The latter might just make it back this weekend, which would be a huge boost to a team that averaged just one yard per carry against Tampa Bay last Sunday. Even so, I think this is a bad road match-up for them right now.

Cardinals to win

And the rest

Here are the rest of this week's games. These are not included in the Pick Six, but feel free to post your winners for these as well. If you do so then please keep them separate from your Pick Six predictions, as it will make life a lot easier when tallying up your scores.