Introduction: Various species of the genus Phyllanthus are used in natural medicine. Multiple studies in vitro and in vivo tested antiviral, anti-tumor, anti-inflammatory and anti-microbial properties. Numerous investigations show that the origin of the antiviral activity of these species is due to the presence of phenolic compounds that inhibit DNA polymerase and reverse transcriptase in the replication of DNA. Studies in two endemic species of Cuba demonstrate antiviral activity evidenced by: inactivation of surface antigen Hepatitis B viral, inhibition of multiplication of herpes simplex type 2 virus(HSV-2) in human foreskin fibroblasts (FPH) and bovine type 1 herpes virus (BHV-1) in bovine kidney cells (MDBK). The possibility of antimicrobial activity of extracts with antiviral properties would provide added value for topical use, since many opportunistic microorganisms infect broken skin regions. It is for these reasons that the work aims at studying the antimicrobial action of aqueous extracts of Phyllanthus chamaechristoides ssp baracoensis URB. (Webster) and Phyllanthus orbicularis HBK against reference strains of pathogenic organisms such as Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa and Candida albicans rigged to the quantification of phenolic compounds present in these. Material and Methods: For antimicrobial activity against the organisms, microdilution in broth technique was used. The quantification of the phenolic compounds was performed by colorimetric technique of colored complexes with ferric salt by reaction in alkaline medium with absorbance reading at 490 nm. Results: None of the extracts had a significant inhibition allowing antimicrobial activity correlate with the concentration of phenolic compounds. The possibility of microbial action of these plants is not discarded as fractions of low polarity are positive for other species.