Status of Pharmacogenomics Research in India during the last five years

Abstract

Studies related to pharmacogenomics have considerably increased in recent years in India. The interests shown by our researchers are largely reflecting the global trend towards the multi-omics approach comprising transcriptomics, proteomics, metabolomics and microbiomics techniques which could help in accomplishing the most precise and personalized way of disease management. Pharmacogenetic trials related to bronchial asthma, breast cancer, acute lymphoblastic leukemia, chronic myeloid leukemia, colorectal cancer, head and neck cancer, rheumatoid arthritis, epilepsy, schizophrenia, major depressive disorder, bipolar disorder, diabetes mellitus, acquired immune deficiency syndrome (AIDS) and tuberculosis are included in this review; pharmacogenetic studies involving drug-groups like anticoagulants, antiplatelets, statins and others are also reviewed. Conditions like breast cancer and drugs such as warfarin, acenocoumarol and clopidogrel were found to be studied more extensively than others. On the other hand, a minimal number of pharmacogenetic studies were done in the field of diabetes, bronchial asthma, tuberculosis, and AIDS.