Minimizing Injection Site Reactions

If you're taking Enbrel or Humira, you may find that you experience swelling, itching, or redness at the site of injection. This type of reaction is normal and is not an allergic reaction. There are several ways that it can be reduced. The good news is most patients find that these reactions decrease the longer they take their medications. See below for more details.

If you experience swelling on your face, eyes, lips, or mouth, feel feverish, or have trouble breathing, you may be having an allergic reaction and should seek medical attention.

Rotating the Injection Site

Rotating the injection site prevents injection site reactions. You can inject yourself: in the abdomen, at least 2 inches from your belly button; on the front of your upper thigh; or the back of your upper arm, near your triceps. Try to inject in altogether different places to minimize the risk of scarring and injection site reactions. For example, if you used your right thigh last time, use your abdomen or left arm this time.

Icing

Applying an ice pack to the swollen or red area for twenty minutes will help soothe it.

Antihistamines

﻿Taking an antihistamine such as benadryl prior to or soon after your injection will help to reduce itching. If you plan on being awake that day, you can also apply a topical antihistamine such as benadryl cream.

NSAIDS

Anti-inflammatory pain relievers such as ibuprofen (Motrin or Advil) or acetaminophen (Tylenol) can also minimize this reaction.