Orexins A and B are hypothalamic neuropeptides, in the regulation of food intake, metabolic rate, cardiovascular function, body temperature, locomotor activity, sleep-wake cycle and stress response. These peptides derive from the prepro-orexin (preprohypocretin) gene, which encodes a precursor that is cleaved into orexin-A and orexin-B

Orexins A and B, also known as hypocretin 1 and 2, are neuropeptides derived from a common 130-amino acid precursor peptide, prepro-orexin (PPO), by proteolytic cleavage. Orexin A is a 33-amino acid residue peptide with two intramolecular disulphide bonds in the N-terminal region, whereas orexin B is a linear 28-amino acid residue peptide. The discussed peptides have a 46% sequence identity. Both orexins act via two closely related G-protein coupled receptors, orexin type 1 receptor (OX1R) and orexin type 2 receptor (OX2R). OX1R appears to be selective for orexin A, while OX2R binds both orexin A and orexin B[1].

Orexin-A controls glucose production and utilization in the peripheral tissues via the autonomic nervous system. In addition it has been shown that orexins A and B differentially regulate glucagon release from pancreas. In addition, the presence of orexin receptors in other cerebral areas suggests that orexin-A plays additional functions. It has been demonstrated that the orexins play a role in sleep regulation[2]

Some reports show that Orexin B (ORXB) modulates the function of peritoneal macrophages through activation of calcium-dependent potassium channels and induces enhancement of phagocytosis in mouse peritoneal macrophages. it is plausible that ORXB may function as an anti-infective molecule. However, it has not been reported whether ORXB has antimicrobial properties[3].

KareBayTM provides scientists and clinicians with a wide range of biotechnological products and science lab supplies for chemical research and analyzing life processes. KareBay's extensive capabilities include commercializing reagents and kits, manufacturing biotech products and providing contract research services to organizations worldwide. Our many global labs, offices, and business partners enable KareBay to extend its products and services to its customer base around the world.

Our products are used for research, laboratory and further evaluation purposes. They are not for human use.