Au unknown 55 years old man with loss of consciousness, bradypnea, cyanosis and miotic pupil was referred to hospital from a bus terminal. Neurological examination revealed no lateralized sign and acrocyanosis was positive. A short time after administration of hypertonic glucose and naloxone, he had seizure, hypotension and apnea, therefore, he underwent intubation and mechanical ventilation. Primary laboratory examinations revealed respiratory acidosis and hypoxemia. After brain CT scanning and other lab tests, he received naloxone again and showed more consciousness. Since the man was on suspicion of body packing, plain abdomen X-ray was done and the existence of several packs was confirmed. Treatment by polyethylene glycol 2 lit/h and naloxone and serial activated charcoal started and finally, the patient excreted the packets and was then discharged with good condition.