Medford's Kyle Singler had a career-high 20 points while leading the Pistons in minutes played at 36:41. He also had eight rebounds, three blocks and two steals.

The Pistons never trailed, despite playing without Jose Calderon — the man they acquired from Toronto in Wednesday's three-team deal. The Spanish-born point guard was unavailable to play because of visa issues.

Knight, also a point guard, might play off the ball more once Calderon is in the lineup.

"Great player — done a lot of good things over his career, and definitely a big help for us coming in," Knight said. "We'll get used to playing with one another and see how it works out."

Knight was a lottery pick two years ago, so Calderon's arrival won't necessarily mean a reduced role for the 6-foot-3 guard. He may be asked to become more of a scorer, though.

He made his first four shots Friday, and the Pistons opened an early 21-11 lead on a dunk by Monroe. Cleveland shot only 22 percent from the field in the first quarter. The Cavaliers finished at 40 percent.

Knight more than held his own against Cavaliers star Kyrie Irving, who was the No. 1 pick in the 2011 draft — when Knight was taken eighth by Detroit.

"We came out soft, and we played that way for the whole game. I take full responsibility for that, because I didn't play with energy, and that trickles down to the rest of the team," Irving said. "I let things that happened in the game bother me, and I got disinterested and let the game get away from me. I can promise that won't ever happen again."

Tristan Thompson led Cleveland with 19 points.

Detroit led 54-47 at the half and extended its advantage in the third quarter. Knight made a 3-pointer followed by a pair of free throws to make it 79-64. A jumper by Knight gave the Pistons their largest lead at 85-66 late in the quarter.

Detroit is 3-0 against Cleveland this season. Irving didn't play in either of the first two meetings, and now the Cavaliers are without center Anderson Varejao for the rest of the season.

Varejao was treated recently for a blood clot in his right lung.

Irving scored 14 points. Cleveland managed 20 offensive rebounds in each of the first two losses to the Pistons. Without Varejao, the Cavaliers had only 13 this time.

"That's the third time we've played that team, and they've played harder every time and they've been tougher every time. Maybe we need to go back to 21/2; or three-hour practices and run up and down the floor," Cleveland coach Byron Scott said.

"I asked our guys if they were content being 13-34, because if they are, let me know and we can make some changes," he added.

Cleveland had won three of four entering the game, and the Cavaliers had outscored each of those opponents in the fourth quarter. That streak ended Friday, when Detroit won the fourth 32-31.

Cleveland cut the deficit to nine at 99-90 in the fourth when C.J. Miles made a 3-pointer following a pair of missed free throws by Detroit rookie Andre Drummond.

The Pistons took Drummond out, so the Cavaliers began fouling Charlie Villanueva intentionally. Villanueva went 3 of 6 from the line during that stretch, but Cleveland couldn't take advantage.