Article Details

Neuroprotective Role of Agmatine in Neurological Diseases

Author(s):

Abstract:

Background: Neurological diseases have always been one of the leading cause of mobility and mortality world-widely. However, it is still lacking efficient agents. Agmatine, an endogenous polyamine, exerts its diverse biological characteristics and therapeutic potential in varied aspects.

Methods: This review would focus on the neuroprotective actions of agmatine and its potential mechanisms in the setting of neurological diseases.

Conclusions: The safety and low incidence of adverse effects indicate the vast potential therapeutic value of agmatine in the treatment of neurological diseases. However, most of the available studies relate to the agmatine are conducted in experimental models, more clinical trials are needed before the agmatine could be extensively clinically used.