More side effects than other sulfonylureas and generally not
recommended. Hypoglycemic risk results in this drug
typically being an unacceptable choice for elderly patients
and those with mile to moderate hepatic and renal
dysfunction.

Slowly metabolized; active metabolites

Some drug drug interactions (dicumarol,
phenylbutazone, or some sulfonamides)

Chloropropamide may induce prolonged
hypoglycemia in elderly patients dilutional hyponatremia -- results
from enhanced vasopressin secretion and potentiation of its
effect at the renal tubule by chlorpropamide (Diabinese).

Emergency treatment in insulin-dependent
unconscious patients in which intravenous glucose cannot
be administered (a conscious patient would be treated by
drinking orange juice or other high sugar content foods)