Sunday, August 25, 2013

At the age of 88, my seemingly healthy and vigorous father
suddenly died. He had commanded an army,
lived through a revolution, met kings and presidents, and through it all raised
a family. And then one night, all those
memories, all those experiences, vanished.
Coming home from the funeral I realized that a library, stacked with
history books, had burned to the ground.

When we experience something, it can become a memory. But what is this memory? What is its neural substrate? Can someday memories that we store in our
brain be read out and stored in a machine?
Is there any hope that the library can be saved from the fire that
consumes us as we die?

Standard model of memory

Our model of memory today is one of synaptic
plasticity. When we experience
something, the neurons that are engaged by that experience produce electrical activity, and that
activity can alter the strength of synapses that connect them to other
neurons. The electrical activity can also result in
growth of new synapses. Together, this
altered strength of connectivity in an existing network of neurons is thought
to be the basis of memory. So in
principle, if one could measure the strength of each synapse, and model the
functional properties of each neuron, then one has a representation that
approximates the state of brain of an individual. The lifetime of memories and experience are
within this representation.

The problem, unfortunately, is that this concept of memory relies
on the assumption that neurons themselves are fixed nodes, whereas the
connections (that is, the synapses) are the changing components through which
memories are stored. This assumption, as
it turns out, is false. New neurons are
born every day, and the human brain, even in old age, adds and subtracts nodes
to the network.

Finding a neuron’s birthday

Between 1955 and 1963, there were numerous above ground tests
of nuclear weapons. With every
explosion, the amount of isotope 14C was elevated in the atmosphere. In 1963, there was a treaty that banned such
tests, and since then the atmospheric level of 14C has declined because of
uptake by plants. This uptake takes
place as 14C in the atmosphere reacts with oxygen to make CO2, which is then
taken up by plants in photosynthesis.

When we eat plants, or eat animals that feed on plants, the
14C is transferred to our body. Once
transferred to our body, 14C becomes part of the DNA of new born cells. This happens when a cell divides and makes a
copy of its chromosomes. The copying
process integrates the 14C into the newly made genome, making it so that by
looking at the concentration of 14C in a cell’s DNA, and comparing it to the
atmospheric DNA, one can tell when that cell was born.

Kristy Spalding, Jonas Frisen, and their colleagues used
this idea to find the birthday of neurons in the human brain. In their study, they examined brains of people
who had died between 2000 and 2012.
These people had had their brains preserved during autopsy, and so their
brain could be studied.

They focused their efforts on the neurons in the hippocampus
region of the brain, a location that is critical for formation of new memories. The hippocampus is the place in our brain
where we form autobiographical memories, i.e., the kind of memories that
describe places and people that we have met, events that have taken place in
our life, etc. Spalding and colleagues
asked, how old are the neurons in the hippocampus of a person who was 30 years
old when she died? You might guess,
well, the neuron is probably close to 30 years old. But that assumes that all neurons are born soon
after birth. Strikingly, Spalding and
colleagues found that the neurons were much younger than the person.

Neurons are much younger than the age of the person

The authors found that for a 20 year old, the average age of
neurons in the hippocampus was 18. For a
40 year old, the average age was 29. For
a 60 year old the average age was 37.
Remarkably, for an 80 year old, the average age of hippocampal neurons was
40!

So the average neuron in the
hippocampus of an 80 year old has been around only long enough to experience
the last 40 years. It cannot ‘remember’
anything from the first half of life, because it was not around to experience
it.

Therefore, there is substantial neurogenesis throughout life
in the hippocampus. In fact, the rate of
neurogenesis showed only a modest decline with aging. They estimated that each day, 0.004% of the
neurons in the dentate gyrus of the hippocampus die and are replaced with new
ones.

Now it is possible that neurogenesis in the hippocampus is
especially high, and other parts of the cerebral cortex may not have such a
high turn-over.But the relative youth
of the neurons in the hippocampus raises a fundamental question:what is memory if neurons are eliminated and
replaced on a daily basis?

Richard Feynman, the celebrated physicist, during a lecture
in 1955 to the National Academy of Sciences, described the basic problem:

“The radioactive phosphorus content of the cerebrum of the
rat decreases to one half in a period of two weeks. Now what does that mean? It means that phosphorus that is in the brain
of the rat, and also in mine, and yours, is not the same phosphorous as it was
two weeks ago. It means the atoms that
are in the brain are being replaced: the ones that were there before have gone
away. So what is this mind of ours: what
are these atoms with consciousness? Last
week’s potatoes! They now can remember what was going on in my mind a year ago,
a mind which has long ago been replaced.
To note that the thing I call my individuality is only a pattern or a
dance… The atoms come into my brain, dance a dance, and then go out--- there
are always new atoms, but always doing the same dance, remembering what the
dance was yesterday.”

The problem in neuroscience is to understand how to read
this dance. If we could, then in
principle it should be possible to record and preserve our experiences, so that
when we die, the library will remain standing.

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About Me

I was born in Iran and immigrated to the US at the age of 14. I was educated at Gonzaga University, University of Southern California, and finally MIT. I studied under the mentorship of Prof. Michael Arbib and Prof. Emilio Bizzi. I am currently Professor of Biomedical Engineering and Neuroscience, and the Director of the BME PhD Program at Johns Hopkins School of Medicine. I am a neuroscientist who uses mathematics to understand how the brain controls our movements.