Indication: CONTRAVE® (naltrexone HCI/bupropion HCl) is a prescription weight-loss medicine that may help adults with obesity (BMI greater than or equal to 30 kg/m2), or who are overweight (BMI greater than or equal to 27 kg/m2) with at least one weight-related medical condition, lose weight and keep the weight off. CONTRAVE should be used along with diet and exercise.

Limitations of Use: The effect of CONTRAVE on cardiovascular morbidity and mortality has not been established. The safety and effectiveness of CONTRAVE in combination with other products intended for weight loss, including prescription drugs, over-the-counter drugs, and herbal preparations, have not been established.

Meet people who have lost weight and kept it off with CONTRAVE, the #1 prescribed weight-loss brand.1

"It seems like most things work at the beginning and dwindle off, but CONTRAVE is working long-term for me." - JoAnn

JoAnn's Story

Like many moms, JoAnn found herself struggling with cravings and controlling her weight since her first child was born over 25 years ago. Coupled with the removal of her thyroid, JoAnn’s weight-loss journey has not been easy.

“I felt like I had tried it all, but everything was the same,” JoAnn reflects. “With diets, exercise and weight-loss programs, I would lose about 10 to 15 pounds – if I lost any weight at all – before I plateaued and regained it. I even tried phentermine and wasn’t quite as hungry, but I didn’t like it because it didn’t control my cravings at all. If I saw a cake I would eat it.”

Actual patient. Results not typical. Weight loss is influenced by various factors, including diet and exercise. In one study, patients who took CONTRAVE for a full year and participated in an intensive diet and exercise program lost 25 pounds on average.

A New Treatment Option

When JoAnn reached her heaviest weight at 277 pounds in November 2016, her new healthcare provider recommended she try weight-loss treatment with CONTRAVE. “When I started taking CONTRAVE, it was just different,” she reflects. “Before, I would do pretty well throughout the day, but when I wasn’t quite as busy or came home, I could not stop eating. Now, I eat smaller portions and feel satisfied – I don’t feel like I have to keep eating.”

Long Term Goals

Since starting treatment with CONTRAVE in November 2016, JoAnn has lost more than 10% of her body weight and continues to maintain her weight loss. “It seems like most things work at the beginning and dwindle off, but with CONTRAVE, I’ve seen the weight come off and stay off! I don’t want to regain it. I felt hopeless before but now I am motivated!”

JoAnn is excited to begin traveling again and plans to go on a cruise with her family. “My weight had really started to limit what I could do and I wasn’t able to walk very far without pain in my legs,” she reflects. “Now that I have lost weight, I’m no longer experiencing pain when I walk and I’m excited to start making plans again!”

Actual patient. Results not typical. Weight loss is influenced by various factors, including diet and exercise. In one study, patients who took CONTRAVE for a full year and participated in an intensive diet and exercise program lost 25 pounds on average.

"I had resigned myself to being obese and never thought I would be ‘normal’. With CONTRAVE, I feel renewed." - Jeffery

Jeffery's Story

By Jeffery’s own account, he had been overweight his whole life. At 5’11” and 315 pounds, he decided to undergo a gastric sleeve procedure in 2013. While successful at first, he was disappointed at gaining all of the weight back just six months after the procedure. “The surgery didn’t do anything to suppress my eating habits – it never got to the root cause of what was wrong,” Jeffery explained. “I don’t mind saying that I feel like I’m an addict – just not to alcohol. I used food for everything whether I’m bored, lonely, happy or sad.”

The physical reality and personal disappointment of having regained the weight caused Jeffery to miss out on a number of activities that were important to him. He stopped going to football games for the Houston Texans – his favorite team. Over the years, he cancelled trips because he was uncomfortable on airplanes due to the small seat size and seatbelt. That same discomfort almost deterred him from traveling to Minnesota to spend Christmas with his family, but in the end, he decided to purchase a first-class plane ticket instead to avoid being in pain. “I was so heavy that I wasn’t enjoying anything. I was just horribly uncomfortable,” he reflects.

Actual patient. Results not typical. Weight loss is influenced by various factors, including diet and exercise. In one study, patients who took CONTRAVE for a full year and participated in an intensive diet and exercise program lost 25 pounds on average.

Addressing the Root of the Problem

As a registered nurse who also teaches nursing psychology at a local college, Jeffery understood that his eating habits went beyond willpower. One day, while watching TV, he saw a commercial for CONTRAVE and said to himself “this might actually work!’”

The educator in him wanted to learn more so he visited the CONTRAVE website. “I believe so strongly that obesity results from an addiction to food, so I was eager to try.” From the comfort of his home, he decided to visit Get CONTRAVE Now. After completing a comprehensive medical questionnaire: “I facetimed with a physician through my iPad and it couldn’t have been easier!” Jeffery learned that he was a candidate for CONTRAVE, and a few days later, he received his prescription.

Breaking the ‘Vicious Cycle’

Since starting treatment with CONTRAVE in March 2017, Jeffery has lost more than 10% of his body weight. “Now I can eat one cookie without eating the whole bag. I go to dinner with my friends, but I cut the portion in half,” he explains. “With CONTRAVE, I want to succeed and I know that I will.”

Motivated to Succeed

Jeffery’s final push to lose weight and keep it off was partially due to his excitement about starting a four-year PhD program in nursing. “When I’m stressed, I can’t stop eating. I knew if I was going to do this, I needed to do it right and get my weight under control.” He beams about his first moment of weight-loss success: “I was able to attend my interview in a suit that fit me nearly 15 years ago and realized my pants weren’t going to be too tight! I even took a couple of pictures!”

Jeffery looks forward to successfully completing his PhD program, in addition to resuming activities that once brought him joy, but have been on hold because of his weight. “I’m looking forward to being able to ride rollercoasters, travelling and being comfortable with myself at the beach,” he shares. “I still wear my J.J. Watt jersey when I’m at home watching the Houston Texans games, but it’s not as good as in-person. I signed up for the season ticket lottery three years ago and am hoping to lose more weight before I get those seats!” he said.

“I had resigned myself to being obese for the rest of my life, but I’ve changed my mindset. With CONTRAVE, I feel like I have hope.”

Actual patient. Results not typical. Weight loss is influenced by various factors, including diet and exercise. In one study, patients who took CONTRAVE for a full year and participated in an intensive diet and exercise program lost 25 pounds on average.

"I never understood why I wasn’t able to control my hunger, but now there’s more of a scientific explanation: it’s not just about willpower." - Teri

Teri's Story

Teri couldn’t understand the duality of it all: why had she been able to maintain the willpower to push through required number crunching for her Master’s in Business Administration classes, but couldn’t control her hunger and cravings?

As a busy working mom, active member of her community, minister, board member of non-profit organizations, and mentor for local businesswomen, Teri felt that it was impossible to gain control of her diet – often resorting to eating something on the go or at a restaurant. In 2007, she hoped that she had solved the problem with gastric bypass surgery, which resulted in a 95-pound weight loss over the course of nine months, but found that she quickly regained the weight.

Actual patient. Results not typical. In one study, patients who took CONTRAVE for a full year and participated in an intensive diet and exercise program lost 25 pounds on average.

Years later, in November 2016, Teri had grown weary of hearing about fad diets that only resulted in temporary change. She had recently started educating healthcare professionals about CONTRAVE as part of her role as a pharmaceutical sales representative supporting Orexigen Therapeutics, Inc. Learning about CONTRAVE at work, Teri approached her own doctor about whether starting CONTRAVE was right for her.

“There are areas of the brain that have been identified to hinder your progress,” Teri explains. “I never understood why I wasn’t able to control my hunger, especially my cravings for sweets, but now there’s more of a scientific explanation: it’s not just about willpower.”

Since starting CONTRAVE in November 2016, Teri has lost more than 10% of her body weight and continues to maintain her weight-loss. “When I used to diet, it would kill me not to eat the cake. Now, after two forkfuls I have the same satisfaction that I did six months ago from a big piece of cake.”

“This is the first time in five years that I’ve worn a dress that was knee length. I felt like I was walking in NY fashion week and I can now cross my legs while sitting down!” Teri beams.

In addition to taking CONTRAVE, she watches her diet and tries to walk 8,000 steps a day, which she monitors with her wearable fitness tracker. Not only is she gaining control over her diet and implementing healthy habits, but she has also inspired her family to live a healthier lifestyle.

Teri is most proud of the impact her transformation has had on her 11-year-old daughter. “I’m now healthier for my daughter and I’m so happy that I’m changing her outlook on health and eating right. She recently said ‘Mommy I want to be like you, I want to be healthier.’”

Actual patient. Results not typical. In one study, patients who took CONTRAVE for a full year and participated in an intensive diet and exercise program lost 25 pounds on average.

"I no longer feel like I need to eat that extra piece of cake." - Katina

Katina’s Story

For the past 20 years Katina has been fighting to take control of her weight. Since her teenage years, her emotional eating had been triggered by feelings of stress or anxiety. “I kept trying to lose the weight, but just got stuck.”

Actual patient. Results not typical. Weight loss is influenced by various factors, including diet and exercise. In one study, patients who took CONTRAVE for a full year and participated in an intensive diet and exercise program lost 25 pounds on average.

A Friend’s Inspiration

After seeing a friend’s success with CONTRAVE, Katina decided to speak with her doctor. Together, they decided she would be an appropriate candidate for the medicine. Since starting CONTRAVE, Katina has lost more than 20% of her body weight over the course of the past year. “I am just amazed, I no longer feel like I need to eat that extra piece of cake.”

A New Lifestyle

In addition to CONTRAVE, Katina also diets and is an active runner. Even after a knee replacement and a doctor telling her that she would most likely never run again, Katina has participated in multiple races and is currently training for a half marathon. She joins fellow colleagues once a week to play recreational soccer and uses fitness apps and wearable devices to help her track meals, workouts, and progress towards meeting her fitness goals. “It’s not a magic pill, but it does provide support,” Katina says of CONTRAVE. “I still diet and exercise, and think it is important to measure your success to keep yourself on track.”

Since her weight loss, her husband said she is the happiest he has ever seen her. “(My weight loss) has definitely changed my perspective on my health,” Katina explains with a smile.

Katina recently went on vacation with her husband and two children to Colorado. As a result of her weight-loss with CONTRAVE, combined with diet and exercise, she was able to join her family as they went hiking in the park and tubing down the river. She enjoys spending moments like these with her family and friends.

Actual patient. Results not typical. Weight loss is influenced by various factors, including diet and exercise. In one study, patients who took CONTRAVE for a full year and participated in an intensive diet and exercise program lost 25 pounds on average.

"With CONTRAVE, I no longer crave my usual go-to foods. Now I’m able to eat to live, not live to eat." - Janine

Janine's Story

Janine, a nurse, wife, and busy mom to four children, has long struggled with her weight. It began when she was in her early 20s. “I had my first child at 22 years old and then another at 25 and just couldn’t seem to keep it under control,” she says.

From that point on, Janine’s struggle continued. “I would maintain my weight loss for a while and then gain it all back,” she says.

Actual patient. Results not typical. Weight loss is influenced by various factors, including diet and exercise. In one study, patients who took CONTRAVE for a full year and participated in an intensive diet and exercise program lost 25 pounds on average.

Weight-loss diets and treatments failed her

Over the years, Janine tried a variety of diets and weight-loss programs to help her lose weight. When those diets failed to deliver the results she was hoping for, she reached out to her doctor to discuss other treatment options. She tried several weight-loss medications, but stopped because of the side effects.

Feeling sad and defeated

With little luck managing her weight, Janine’s social life and feelings of self-worth began to suffer. “I was exhausted all the time,” she says. “I never wanted to go out or meet new people because I was the fat girl. I didn’t want to go out to dinner because I didn’t want to be judged when I ate. It really decreased my self-esteem and put me down in the dumps,” she says.

Trying something new

Then one day she happened to see a photo of herself after being featured on the news. “I saw that photo and thought, ‘I’m done feeling like this,’” Janine recalls.

Janine went to her doctor again, and this time he recommended CONTRAVE, a weight-loss medication Janine had not yet considered. Taking her doctor’s advice, Janine decided to give it a try.

Getting results

Since starting CONTRAVE Janine has lost more than 10% of her body weight. “I used to get up and eat in the night, and I don’t do that anymore,” She explains, “Now, I want to make sensible decisions about what I eat and feel like I’m eating to live and not living to eat.”

Losing weight with CONTRAVE has helped Janine get back to being the confident, active person her friends and family always knew her to be. “I’ve scheduled myself to do more presentations at work because I’m not self-conscious about standing in front of my colleagues and patients anymore,” she says. “Everyone has noticed my weight loss, which has even inspired others to lose weight,” she shares. “But honestly, the most significant benefit is how I feel. I feel just fabulous!”

Actual patient. Results not typical. Weight loss is influenced by various factors, including diet and exercise. In one study, patients who took CONTRAVE for a full year and participated in an intensive diet and exercise program lost 25 pounds on average.

"I used to huff and puff up a flight of stairs, but now that I’ve lost weight I can hike in the mountains with my son again." - Jim

Jim's Story

As an outdoorsman, Jim enjoys traveling the world and immersing himself in nature whenever possible. But his struggle with his weight almost brought that lifestyle to an end.

One day when he was in his 40s, he went for his yearly physical before venturing out into the woods. “The nurse handed me a card that said, ‘Please stay out of the woods, we don’t want to have to save you,’” he recalls. It was the first time Jim realized he was overweight.

Actual patient. Results not typical. Weight loss is influenced by various factors, including diet and exercise. In one study, patients who took CONTRAVE for a full year and participated in an intensive diet and exercise program lost 25 pounds on average.

Finally getting motivated

Although this pivotal memory stuck with Jim, he admits it took him decades to find the motivation to lose weight. As his weight increased and he became less active, Jim recalls his family giving him grief. “You can absorb all the heckling until you finally make up your own mind.”

Finally, Jim decided he was tired of feeling lethargic and spending his time eating and watching TV. He made up his mind to dedicate himself to making healthier choices and started exercising daily and following diets aimed at cutting carbs and sugars.

Sabotaged by snacking

But even with a healthier diet and daily exercise, Jim still couldn’t control his mindless snacking. “I would tell myself I’m not going to eat and the next thing I knew I would have my head stuck in the refrigerator,” he said.

Over time, Jim noticed his habit for snacking made it difficult for him to keep the weight off, and he wasn’t achieving the weight-loss results he desired. “I was working hard to lose the weight, but I had reached a plateau and wasn’t able to break through,” he says.

A plan that finally worked

Looking for something to help him control his hunger, Jim went to his doctor, who recommended CONTRAVE. Jim says, “At this point, I really wanted to lose the weight; I was tired of being fat. So when he suggested CONTRAVE, I leaped at it,” he recalls.

Jim has lost more than 10% of his body weight since starting CONTRAVE. He says it has helped him overcome his weight-loss plateau by helping him control his impulses and cravings. Combined with a healthy diet and exercise, Jim says he is seeing results. “I used to huff and puff up a flight of stairs,” he reflects. “Now, because of my weight loss, I go and hike mountains with my son.”

Jim encourages others struggling to lose weight to “take small steps every day in the right direction, and get smart about what you’re eating.” Overall, Jim feels happier, healthier, and more energetic. “I have a better attitude and a more positive self-image,” he says.

Actual patient. Results not typical. Weight loss is influenced by various factors, including diet and exercise. In one study, patients who took CONTRAVE for a full year and participated in an intensive diet and exercise program lost 25 pounds on average.

"Now that I’m using CONTRAVE, I no longer feel like snacking!" - Brooke

Brooke's Story

Having competed in pageants since she was 18 years old, Brooke was always conscious of her health and diet. She continued to live a healthy lifestyle into adulthood, but two major operations in the span of five years left her struggling to lose – and keep – the weight off. “I was so disappointed in myself,” she explains, recalling her peak weight of 181 pounds at just 5’2”.

Actual patient. Results not typical. Weight loss is influenced by various factors, including diet and exercise. In one study, patients who took CONTRAVE for a full year and participated in an intensive diet and exercise program lost 25 pounds on average.

The Yo-Yo Effect

Brooke had previously lost 40 pounds through crash-dieting and training for a fitness competition, but like so many others who have experienced the yo-yo effect after dropping a significant amount of weight, Brooke quickly put the weight back on. “I ate through my emotions and I couldn’t stop.” In the past, difficult times would trigger emotional eating and cravings.

Finding the Right Treatment

As she continued to watch her weight fluctuate and experiment with weight-loss treatments, Brooke’s doctor expressed concern about her inability to keep the weight off. “I feel like I need help,” she finally confessed under tears.

That’s when her doctor recommended she start treatment with CONTRAVE.

Since beginning treatment in July 2015, Brooke has lost – and kept off – more than 10% of her body weight. “I no longer feel like snacking!”

Life with CONTRAVE

Brooke is now focusing on eating a healthier diet and controlling her portion sizes. Her BMI is back in the normal range and she is getting closer to her weight-loss goal. “I go to buy clothes in smaller sizes, which I haven’t been able to do in years!” Brooke says with a smile. Friends and family have also taken notice, often commenting on her lasting results.

Cravings curbed, Brooke feels she is back in control and able to focus on the things she is passionate about, such as volunteering, participating in pageants and using her public platform to raise awareness for Alzheimer’s. Brooke also looks forward to spending more time with her husband and son in Lake Tahoe, continuing to build her photography business, and writing for her blog.

Actual patient. Results not typical. Weight loss is influenced by various factors, including diet and exercise. In one study, patients who took CONTRAVE for a full year and participated in an intensive diet and exercise program lost 25 pounds on average.

One of the ingredients in CONTRAVE, bupropion, may increase the risk of suicidal thinking in children, adolescents, and young adults. CONTRAVE patients should be monitored for suicidal thoughts and behaviors. In patients taking bupropion for smoking cessation, serious neuropsychiatric adverse events have been reported. CONTRAVE is not approved for use in children under the age of 18.

Stop taking CONTRAVE and call a healthcare provider right away if you have any of the following symptoms, especially if they are new, worse, or worry you: thoughts about suicide or dying; attempts to commit suicide; depression; anxiety; feeling agitated or restless; panic attacks; trouble sleeping (insomnia); irritability; aggression, anger, or violence; acting on dangerous impulses; an extreme increase in activity and talking (mania); other unusual changes in behavior or mood.

Do not take CONTRAVE if you have uncontrolled high blood pressure; have or have had seizures; use other medicines that contain bupropion such as WELLBUTRIN, APLENZIN or ZYBAN; have or have had an eating disorder; are dependent on opioid pain medicines or use medicines to help stop taking opioids such as methadone or buprenorphine, or are in opiate withdrawal; drink a lot of alcohol and abruptly stop drinking; are allergic to any of the ingredients in CONTRAVE; or are pregnant or planning to become pregnant.

Before taking CONTRAVE, tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Do not take any other medicines while you are taking CONTRAVE unless your healthcare provider says it is okay.

Tell your healthcare provider about all of your medical conditions including if you have: depression or other mental illnesses; attempted suicide; seizures; head injury; tumor or infection of brain or spine; low blood sugar or low sodium; liver or kidney problems; high blood pressure; heart attack, heart problems, or stroke; eating disorder; drinking a lot of alcohol; prescription medicine or street drug abuse; are 65 or older; diabetes; pregnant; or breastfeeding.

CONTRAVE may cause serious side effects, including:

Seizures. There is a risk of having a seizure when you take CONTRAVE. If you have a seizure, stop taking CONTRAVE, tell your healthcare provider right away.

Risk of opioid overdose. Do not take large amounts of opioids, including opioid-containing medicines, such as heroin or prescription pain pills, to try to overcome the opioid-blocking effects of naltrexone.

Sudden opioid withdrawal. Do not use any type of opioid for at least 7 to 10 days before starting CONTRAVE.

Severe allergic reactions. Stop taking CONTRAVE and get medical help immediately if you have any signs and symptoms of severe allergic reactions: rash, itching, hives, fever, swollen lymph glands, painful sores in your mouth or around your eyes, swelling of your lips or tongue, chest pain, or trouble breathing.

Increases in blood pressure or heart rate.

Liver damage or hepatitis. Stop taking CONTRAVE if you have any symptoms of liver problems: stomach area pain lasting more than a few days, dark urine, yellowing of the whites of your eyes, or tiredness.

Manic episodes.

Visual problems (angle-closure glaucoma). Signs and symptoms may include: eye pain, changes in vision, swelling or redness in or around the eye.

Increased risk of low blood sugar (hypoglycemia) in people with type 2 diabetes mellitus who also take medicines to treat their diabetes (such as insulin or sulfonylureas).

The most common side effects of CONTRAVE include nausea, constipation, headache, vomiting, dizziness, trouble sleeping, dry mouth, and diarrhea.

These are not all the possible side effects of CONTRAVE. Tell your healthcare provider about any side effect that bothers you or does not go away.

Use of CONTRAVE

CONTRAVE is a prescription weight-loss medicine that may help some adults with a body mass index (BMI) of 30 kg/m2 or greater (obese), or adults with a BMI of 27 kg/m2 or greater (overweight) with at least one weight-related medical problem such as high blood pressure, high cholesterol, or type 2 diabetes, lose weight and keep the weight off.

CONTRAVE should be used with a reduced-calorie diet and increased physical activity

It is not known if CONTRAVE changes your risk of heart problems or stroke or of death due to heart problems or stroke

It is not known if CONTRAVE is safe and effective when taken with other prescription, over-the-counter, or herbal weight-loss products

CONTRAVE is not approved to treat depression or other mental illnesses, or to help people quit smoking (smoking cessation).

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

One of the ingredients in CONTRAVE, bupropion, may increase the risk of suicidal thinking in children, adolescents, and young adults. CONTRAVE patients should be monitored for suicidal thoughts and behaviors. In patients taking bupropion for smoking cessation, serious neuropsychiatric adverse events have been reported. CONTRAVE is not approved for use in children under the age of 18.

Stop taking CONTRAVE and call a healthcare provider right away if you have any of the following symptoms, especially if they are new, worse, or worry you: thoughts about suicide or dying; attempts to commit suicide; depression; anxiety; feeling agitated or restless; panic attacks; trouble sleeping (insomnia); irritability; aggression, anger, or violence; acting on dangerous impulses; an extreme increase in activity and talking (mania); other unusual changes in behavior or mood.

Do not take CONTRAVE if you have uncontrolled high blood pressure; have or have had seizures; use other medicines that contain bupropion such as WELLBUTRIN, APLENZIN or ZYBAN; have or have had an eating disorder; are dependent on opioid pain medicines or use medicines to help stop taking opioids such as methadone or buprenorphine, or are in opiate withdrawal; drink a lot of alcohol and abruptly stop drinking; are allergic to any of the ingredients in CONTRAVE; or are pregnant or planning to become pregnant.

Before taking CONTRAVE, tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Do not take any other medicines while you are taking CONTRAVE unless your healthcare provider says it is okay.

Tell your healthcare provider about all of your medical conditions including if you have: depression or other mental illnesses; attempted suicide; seizures; head injury; tumor or infection of brain or spine; low blood sugar or low sodium; liver or kidney problems; high blood pressure; heart attack, heart problems, or stroke; eating disorder; drinking a lot of alcohol; prescription medicine or street drug abuse; are 65 or older; diabetes; pregnant; or breastfeeding.

CONTRAVE may cause serious side effects, including:

Seizures. There is a risk of having a seizure when you take CONTRAVE. If you have a seizure, stop taking CONTRAVE, tell your healthcare provider right away.

Risk of opioid overdose. Do not take large amounts of opioids, including opioid-containing medicines, such as heroin or prescription pain pills, to try to overcome the opioid-blocking effects of naltrexone.

Sudden opioid withdrawal. Do not use any type of opioid for at least 7 to 10 days before starting CONTRAVE.

Severe allergic reactions. Stop taking CONTRAVE and get medical help immediately if you have any signs and symptoms of severe allergic reactions: rash, itching, hives, fever, swollen lymph glands, painful sores in your mouth or around your eyes, swelling of your lips or tongue, chest pain, or trouble breathing.

Increases in blood pressure or heart rate.

Liver damage or hepatitis. Stop taking CONTRAVE if you have any symptoms of liver problems: stomach area pain lasting more than a few days, dark urine, yellowing of the whites of your eyes, or tiredness.

Manic episodes.

Visual problems (angle-closure glaucoma). Signs and symptoms may include: eye pain, changes in vision, swelling or redness in or around the eye.

Increased risk of low blood sugar (hypoglycemia) in people with type 2 diabetes mellitus who also take medicines to treat their diabetes (such as insulin or sulfonylureas).

The most common side effects of CONTRAVE include nausea, constipation, headache, vomiting, dizziness, trouble sleeping, dry mouth, and diarrhea.

These are not all the possible side effects of CONTRAVE. Tell your healthcare provider about any side effect that bothers you or does not go away.

Use of CONTRAVE

CONTRAVE is a prescription weight-loss medicine that may help some adults with a body mass index (BMI) of 30 kg/m2 or greater (obese), or adults with a BMI of 27 kg/m2 or greater (overweight) with at least one weight-related medical problem such as high blood pressure, high cholesterol, or type 2 diabetes, lose weight and keep the weight off.

CONTRAVE should be used with a reduced-calorie diet and increased physical activity

It is not known if CONTRAVE changes your risk of heart problems or stroke or of death due to heart problems or stroke

It is not known if CONTRAVE is safe and effective when taken with other prescription, over-the-counter, or herbal weight-loss products

CONTRAVE is not approved to treat depression or other mental illnesses, or to help people quit smoking (smoking cessation).

CONTRAVE® is a registered trademark of Nalpropion Pharmaceuticals, Inc.

All other trademarks registered or otherwise are the property of their respective owners.

CON-0240-0018 10/2018

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