Rose released her debut single "Fame", which features Wiz Khalifa, in January 10, 2012,[14] followed by a second single, titled "Loaded", released on February 6, 2012.[15] She then appeared in the eleventh track of her ex-husband's album O.N.I.F.C., titled "Rise Above", along with rappers Tuki Carter and Pharrell Williams, who produced the song.[16] She was managed by Leticia "Tish" Cyrus, mother of singer Miley Cyrus, who is a close friend to Rose and her ex-husband Wiz Khalifa.[17]

Simon & Schuster published her first book, How to Be a Bad Bitch, in which she offers advice and personal anecdotes on everything from finances and career to love and fashion. The cover features an image shot by famed photographer David LaChapelle.[20]

In 2015, Amber Rose filmed, "Walk Of No Shame with Amber Rose," with Funny or Die.[21] The viral video helped promote Amber Rose's SlutWalk, which took place on October 3, 2015 in Los Angeles, California.[22]

In March 2016, Rose launched an emoji app called MuvaMoji,[23] featuring 900 emoji icons that she curated. Upon release, it shot to No. 1 on the App Store charts. She earned $4 million USD from the app.[24]

In 2009, in regard to her sexual orientation, Rose stated, "I'm extremely open with my sexuality. I can be in love with a woman, I can be in love with a man. As far as humans go, I definitely find beauty in everybody, whether they're heavy-set, super-skinny, if they're white, black, Indian, Asian, Spanish. I can see beauty in anybody. If I see a woman and I think she's beautiful and I like her, and she likes me back we can definitely try to be in a relationship together."[39]

On October 3, 2015, Rose led the L.A.-based SlutWalk to honor all women who have been judged and demeaned for their sexual behavior. As part of the event, Rose spoke publicly about the instances of shaming she has experienced, specifically mentioning an incident at the age of 14, when a friend allegedly pulled his genitals out while in a closet with her playing the kissing game "7 Minutes in the Closet". Rose claimed he tricked her into kneeling down in front of him, then threw open the closet door for all of their friends to see, suggesting oral sex had taken place. Rose grew visibly emotional while speaking about the bullying that followed, demonstrating the depth of the trauma the experience caused.[40]