Carrboro, North CarolinaAt this new operation from Matt and Sheila Neal (he's the son of legendary chef Bill Neal), the pastrami and corned beef are house-made, as is the smoked turkey served with avocado salsa, bacon, and mayo on rustic white bread.100 E. Main St., Ste. C; 919-967-2185nealsdeli.com3. ### Ted's Butcherblock

Charleston, South CarolinaThis butcher shop also happens to make the city's best deli sandwiches. Every month, a different artisanal bacon is featured on the popular BLT. Wagyu beef, caramelized onions, mushrooms, and blue cheese garlic aioli add up to a panini you certainly will not find in Italy.334 E. Bay St.; 843-577-0094tedsbutcherblock.com4. ### Be'wiched

Cambridge, MassachusettsThe latest from chef-restaurateur Chris Schlesinger of Cambridge's famed East Coast Grill & Raw Bar, this unpretentious 40-seat ode to the sandwich features a roster of regional specialties, including beef on weck (roast beef on a roll) from Buffalo, muffuletta from New Orleans, and pulled pork from North Carolina.1245 Cambridge St.; 617-868-3065allstarsandwichbar.com6. ### Baguette Box

BaltimoreThe sandwiches at the tiny upstairs counter are the main draw. In summer, we like the lemony albacore and dill salad on marble rye.911 W. 36th St.; 410-889-09529. ### St. James Cheese Company

New OrleansNOLA's famous po'boys and muffulettas aren't the only sandwiches in town, thanks to the offerings at this cheese-driven specialty store. The Gruyère cheese and caramelized onion confit on grilled multi-grain bread is the grilled cheese we wish we'd grown up on.5004 Prytania St.; 504-899-4737stjamescheese.com10. ### Gateway Market & Café

Des MoinesThis sleek, upscale market from chef George Formaro houses a smart café. At breakfast, the best bet is the fried-egg sandwich with Niman Ranch ham and cheddar cheese on griddled ciabatta. For lunch, go with the burger made from Formaro's blend of beef brisket and chuck.2002 Woodland Ave.; 515-243-1754gatewaymarket.com