This largely depends on the class and build, because the true value of a weapon's damage often lies in the feats and enchantments that can be taken for it. More information is needed about your situation, otherwise you'll get a generic answer which disregards such variables, meaning it may not be true in any particular circumstance.
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BESWFeb 24 '13 at 0:45

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/agree with BESW. Fullblade may have the nicest numbers, but most optimizers prefer to use a gouge because it has slightly better damage (8 average versus the fullblade's 6.5), and the combined spear + axe support makes it more versatile despite only having a +2 proficiency bonus, especially if you're optimizing around charging.
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Oblivious SageFeb 24 '13 at 1:00

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Welcome to the site, Eldest. Read our FAQ. It's generally a good idea to wait at least a day for new answers to come in before accepting them, so as to not discourage people. If you can tell us more about your specific circumstances, we'll be able to help you more.
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Brian Ballsun-Stanton♦Feb 24 '13 at 1:34

3 Answers
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The best two handed weapon not taking into consideration build and in terms of damage die and weapon proficiency bonus would probably be the Full Blade from the Adventurer's Vault. With +3 proficiency bonus and 1d12 damage I'm pretty sure it has the highest numbers.

"Easily" the best is a bold claim. What weapon is best for any given character depends on a wide variety of things.
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Oblivious SageFeb 24 '13 at 1:02

True, but the question was "in terms of weapon proficiency bonus and damage" there is no mention of a build or any other details.
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AntonioFeb 24 '13 at 1:19

Does the fullblade have any equivalent in real history or is it purely for the game? It seems to be a variation of a greatsword, but a variation that probably never saw use.
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TimothyAWisemanFeb 24 '13 at 1:26

If you google fullblade you get D&D and other RPGs so I think it would be safe to assume that it is purely for the game. It's still awesome.
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AntonioFeb 24 '13 at 1:31

It depends on intention and synergy from feats. Looking at only the weapons themselves, the Execution Axe has a .075 DPR increase over the Mordenkrad. That's not much. Considering common magical items and feats, the Gouge is best from a whole-character point of view.

First, let's look at the superior weapons available to us that are two-handed and interesting:

Statistically speaking, these are all functionally equivalent without looking at magic item or feat synergy.

Generally the only builds that care about big weapons are focused on charging, and at higher levels the choice of weapon is increasingly constrained by the specific build of the character: higher level chargers will have their choice of weapon dictated by their feats, class features, and magical items. This means that it's only at relatively low levels that a weapon's damage and proficiency bonus are significant considerations.

Most classes have feats and class features that guide towards a specific weapon group. Clearly, this is setting aside plot-relevant choices. Beyond that, most characters' damage comes from the static modifiers added on top of the attack instead of the weapon itself.

The Mordenkrad has the absolutely exceptional Avalanche Hammer which just adds an extra 1[W] on top when you charge.

The Gouge has Surprising Charge (feat), Spear Expertise (bonus on damage when charging) and Vanguard weapon, for a total of an extra 1[W]+1+1d8 on a charge.

The Execution Axe has a not particularly useful expertise (there are some edge cases, but they don't matter statistically speaking) and Vanguard weapon.

And the fullblade has... vanguard weapon. Technically, the increase in accuracy can be claimed to be worth the decrease in overall damage due to the fact that you've got extra stuff on your powers that occur, but that is a function of specific optimization, not general "what's the best weapon."

Fullblade has excellent numbers, but i find the Mordenkrad (Cleric here) was worth the feat for higher minimum damage plus the 'brutal' advantage. The +2 proficiency bonus is average indeed, but as a strength build battle cleric it works out better for me, especially combined with 'Strength of many' and adjacent to my two defender allies (Fighter/Paladin). My friend uses the Ex. Axe and sings it's praises, but i really do think the Mordenkrad is the better superior.