Web-Client VM console getting failed, when I try to open it using the Chrome browser ( VCenter Appliance 5.5 build 2442330 ) . It says page can’t be found. At the same time it was working fine in Firefox.

As per the VMware the issue is because of Chrome 42 is disabling NPAPI plugin by default where as in Firefox is continuing to support NPAPI. Internet Explorer did once, but dropped it in version 5.5 Service Pack 2.

Also VMware recommended to enable the option in our chrome browser:

chrome://flags/#enable-npapi

This will bring the NPAPI options, select enable and restart your browser.

Once I enabled the NPAPI option and rebooted the browser , able to access the VM console.