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A gang of rats has invaded Camp Wa-kee, and stolen the food and medical supplies, hiding them in different areas of the Camp. As such, Packy and Marlon, two diabeticelephants, are tasked with retrieving the stolen goods and clearing out the malicious rodents, while also remembering to take their insulin and check their blood glucose. At the end of the game they face the evil bosses Veets and Yebur of the Lunch Room Crew.

"Packy and Marlon was designed to help remove the stigma of being different so young people with diabetes who played the game with their friends, and saw that their friends did not consider diabetes to be a big issue, would be more willing to do important self-care throughout the day, even when their friends were around. And this is what actually happened".

The game is important in the history of therapeutic gaming, a concept that originated in the mid-1990s with games such as this as the asthma-focused Bronkie the Bronchiasaurus.[3] A six-month study undertaken in 1997 on behalf of Click Health by researchers at Stanford University's Medical Center on 59 diabetic children ages 8 to 16 found that, after playing the game, the children were four times less likely to require urgent care visits than children who had played other games.[4][5] A three-month study found that for kids with diabetes, the game "decreased their diabetes-related emergency room and urgent care visits by 77 percent".[6] The game was also tested in Kaiser hospitals, where it was shown to have given important information to diabetics, while also encouraging the patients to offer support to each other.[7]