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Description of substance: Pale-yellow to brown liquid with a weak, aromatic, amine-like odor.

LEL: . . 1.0% (10% LEL, 1,000 ppm)

Original (SCP) IDLH: 150 ppm

Basis for original (SCP) IDLH: The chosen IDLH is based on the mouse 7-hour LC50 of 149 ppm [von Oettingen et al. 1947 cited by ACGIH 1971].

Short-term exposure guidelines: None developed

ACUTE TOXICITY DATA:

Lethal concentration data:

Species

Reference

LC50

(ppm)

LCLo

(ppm)

Time

Adjusted 0.5-hr

LC (CF)

Derived value

Mice (2,4-)

von Oettingen et al. 1947

149

-----

7 hr

358 ppm (2.4)

36 ppm

Lethal dose data:

Species

Reference

Route

LD50

(mg/kg)

LDLo

(mg/kg)

Adjusted LD

Derived value

Rabbit

Deichmann & Gerarde 1969

oral

-----

600

833 ppm

83 ppm

Rat

Treon et al. 1949

oral

-----

610

847 ppm

85 ppm

Rat (2,3-)

Vernot et al. 1977

oral

-----

930

1,292 ppm

129 ppm

Mouse (2,3-)

Vernot et al. 1977

oral

-----

1,070

1,486 ppm

149 ppm

Rat (2,4-)

Vernot et al. 1977

oral

-----

470

653 ppm

65 ppm

Mouse (2,4-)

Vernot et al. 1977

oral

-----

250

347 ppm

35 ppm

Rat (2,4-)

Lindstrom et al. 1969

oral

-----

1,259

1,749 ppm

175 ppm

Rat (2,5-)

Vernot et al. 1977

oral

-----

1,300

1,806 ppm

181 ppm

Mouse (2,5-)

Vernot et al. 1977

oral

-----

840

1,167 ppm

117 ppm

Rat (2,6-)

Vernot et al. 1977

oral

-----

1,230

1,708 ppm

171 ppm

Mouse (2,6-)

Vernot et al. 1977

oral

-----

710

986 ppm

99 ppm

Rat (2,6-)

Short et al. 1983

oral

-----

1,050

1,458 ppm

146 ppm

Rat (3,4-)

Vernot et al. 1977

oral

-----

810

1,125 ppm

113 ppm

Mouse (3,4-)

Vernot et al. 1977

oral

-----

710

986 ppm

99 ppm

Rat (3,5-)

Vernot et al. 1977

oral

-----

710

986 ppm

99 ppm

Mouse (3,5-)

Vernot et al. 1977

oral

-----

420

583 ppm

58 ppm

Human data: None relevant for use in determining the revised IDLH.

Revised IDLH: 50 ppm

Basis for revised IDLH: The revised IDLH for xylidine is 50 ppm based on acute toxicity data in animals [Deichmann and Gerarde 1969; Treon et al. 1949; Vernot et al. 1977; von Oettingen et al. 1947]. This may be a conservative value due to the lack of relevant acute toxicity data for workers.