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Abstract

Background: Individuals with diabetes are at increased CVD risk. Limited evidence suggests that this is partially attributed to hyperglycemic suppression of macrophage ATP-binding cassette (ABC) transporter mediated cholesterol efflux. The relationship between glucose concentrations and expression of ABC-transporters (ABCA1 and ABCG1) was assessed in human monocytes and leukocytes (study 1) and murine bone marrow-derived macrophages (BMDM) as well as cholesterol efflux in BMDM (study 2).