Her works are often created in collaboration with research scientists and engineers both in the US and abroad. Her productions always employ narratives nascent to technological research, examining their methodologies to amplify the nature of creativity and intuition emerging from an armature of empirical knowledge. The content examines, or displays, through fictive and dramatic scenarios, stories and scripts, aspects of how humans relate to machines.

Her works have received support from the National Science Foundation, Eyebeam Art and Technology Center, The Whitney Museum of American Art, the Swiss Artists-in-Labs Program, the Artificial Intelligence Laboratory at the University of Zurich, The National Science Foundation, The Franklin Furnace Fund for Performance Art, the Greenwall Foundation, the New York State Council on the Arts, PSC-CUNY Research Foundation and the Robert Rauschenberg Foundation. Her writing and articles have been published in national and international publications.

Wortzel is currently a Professor of Entertainment Technology and Emerging Media Technologies at New York City College of Technology, the senior technical college in the City University of New York (CUNY) system. Her keystone course as a teacher is Topics and Perspectives in Emerging Technologies, a collaborative research and projects course open to the entire student body where students from all disciplines at the College.