The 40-year-old actress, who has six children, Maddox, 14, Pax, 11, Zahara, 10, Shiloh, nine, and seven-year-old twins Knox and Vivienne, with 51-year-old husband Brad Pitt, is excited to reach the milestone age in 2025 after undergoing a ''brutal'' preventative double mastectomy as well removing her ovaries and fallopian tubes to reduce her cancer risk in recent years.

She told the November issue of Vogue magazine: ''Both of the women in my family, my mother and my grandmother [who passed due to ovarian cancer], started dying in their 40s. I'm 40. I can't wait to hit 50 and know I made it.''

The Oscar winner says going public with her health issues ''really connected'' her to other women, but the surgeries were a ''hard'' process.

She explained: ''They are not easy surgeries. The ovaries are an easy surgery, but the hormone changes - interesting. We did joke that I had my Monday edit. Tuesday surgery. Wednesday go into menopause. Thursday come back to edit, a little funky with my steps.''

Angelina also admitted her marriage isn't perfect, but insisted she and Brad are nothing like the unhappy couple they play in their upcoming film 'By the Sea'.

She said: ''Brad and I have our issues, but if the characters were even remotely close to our problems, we couldn't have made the film.

''This is the only film I've done that is completely based on my own crazy mind. As artists we wanted something that took us out of our comfort zones. Just being raw actors. It's not the safest idea. But life is short.''