monoamine oxidase inhibitorn. Abbr. MAOI Any of a class of antidepressant and hypotensive drugs that block the action of monoamine oxidase in the brain, thereby allowing the accumulation of monoamines such as norepinephrine.

monoamine oxidase inhibitorAny of a class of antidepressant drugs that block the action of monoamine oxidase in the brain, thereby allowing the accumulation of monoamines such as norepinephrine, which can alter mood.