"I would like the take the opportunity to express our condolences to those families who have lost a loved one to the epidemic," Cordova Villalobos said Monday evening. But while he described the situation as an emergency, "it's not a disaster situation."

A U.S. federal official confirmed the U.S. figure -- up from 20 with all the new cases coming from a New York school where eight cases were previously confirmed.

Dr. Richard Besser, acting director of the Centers for Disease Control and Prevention in Atlanta, Georgia, said only one of the U.S. cases has been hospitalized, and all have recovered.

Besser said it was too early to say how severe how future cases could be. "I fear that as we continue to look for cases, we are going to see cases in this country that are more severe -- individuals who are hospitalized," he said. "And I would not be surprised if we see deaths in this country."

The European Union's health commissioner Monday urged people "to avoid non-essential travel to the areas which are reported to be in the center of the clusters" of a swine flu outbreak.

The EU issued a statement clarifying that Vassiliou's remarks were her personal comments and that travel advisories can be issued only by member states and not by the EU itself.

The first case of swine flu in Europe was confirmed Monday in Spain. Health minister Trinidad Jimenez said a 23-year-old man who returned from studying in Mexico last Wednesday tested positive for the virus at a hospital in the country's southeast.

At least 16 more cases are being treated as possible swine flu, Jimenez told a news conference. Earlier, Jimenez met with health officials to discuss Spain's response to the crisis.

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"We do not have an emergency situation in Spain, but we are working to prevent any possible development, and we are taking action in accord with the World Health Organization," she said.

Spain's Ministry of Health has urged travelers recently returned from Mexico and the U.S. to be on the lookout for symptoms of the virus, including fever, coughing and respiratory problems.

A few hours later, Scottish Health Secretary Nicola Sturgeon said, "Tests have demonstrated conclusively that the two Scottish cases of swine flu are positive."

U.N. Secretary-General Ban Ki-moon said: "We are concerned that this virus could cause a new influenza pandemic. It could be mild, in its effects, or potentially be severe. We do not yet know which way it will go. But we are concerned that, in Mexico, most of those who died were young and healthy adults.

U.S. President Barack Obama said Monday that the outbreak was a "cause for concern" but not a "cause for alarm."

He said the federal government was "closely monitoring" emerging cases and had declared a public health emergency as a "precautionary tool" to ensure the availability of adequate resources to combat the spread of the virus.

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Israel and New Zealand, where 22 students and three teachers were quarantined after returning for a three-week trip to Mexico, are also investigating suspected cases. South Korea says it will test travelers arriving from the U.S.

Swine flu is a contagious respiratory disease that usually affects pigs. It is caused by a type-A influenza virus. The current strain is a new variation of an H1N1 virus, which is a mix of human and animal versions.

When the flu spreads person-to-person, instead of from animals to humans, it can continue to mutate, making it harder to treat or fight off because people have no natural immunity.

The symptoms are similar to common flu. They include fever, lethargy, lack of appetite, coughing, runny nose, sore throat, nausea, vomiting and diarrhea.

The virus spreads when an infected person coughs or sneezes around another person. People can become infected by touching something with the flu virus on it and then touching their mouth, nose or eyes.

In 1968, a "Hong Kong" flu pandemic killed about 1 million people worldwide. And in 1918, a "Spanish" flu pandemic killed as many as 100 million people.