Responses (3)

I don’t think there’s enough evidence to suggest Deplin does anything more than what a folic acid supplement can do. The supplement is worth a shot, Deplin is probably not. I know you’re looking for options, but there are other options out there that are more legit. I’ve felt at the end of the road before and my doctor always has ideas

Do you by any chance have any scientific literature references on that? I'd like to read them :)

My current understanding is that folic acid and l-methylfolate (Deplin) are not the same. Folic acid gets converted into l-methylfolate, which is then used as a building block for neurotransmitters and other essentials. Those with the MTHFR mutation are able to do the conversion, just not as efficiently, depending on the severity of the mutation.

Yea, my options have been mostly medication, complete with nasty side effects. I'm just making sure my body has the proper vitamin/mineral levels, so that I have a good baseline and am not taking loads of medication, when all I really needed was a little bit of medication and a magnesium + Deplin supplements.

No because there isn’t enough research to back Deplin up to even be considered for insurance coverage. 23 and Me doesn’t test the MTHFR gene because so little research supports it. And if you don’t have the right gene, it’s definitely not going to help. The only thing we know for certain is that folic acid supplementation helps to prevent heart issues with the MTHFR gene.

I have the MTHFR gene, I take Deplin 15. I have depression & anxiety. I honestly don’t think it does a damn thing other than my folate levels are normal now. . I’ve been taking it for 2 years. Magnesium is supposed to help with anxiety also, butt... I don’t notice a difference, been taking that for a long time also. I think everything is hit or miss for everyone.

I think it is reasonable to conclude that for a person with a condition (MTHFR) marked by low efficiency of converting folic acid to methylfolate, then supplementing with methylfolate in the form of Deplin could reduce anxiety levels and thus panic disorder symptoms - assuming the person is also avoiding folic acid.