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Ataxia Telangiectasia Mutated Proteins (ATM)

On www.antibodies-online.com are 5 Ataxia Telangiectasia Mutated (ATM) Proteins from 3 different suppliers available. Additionally we are shipping ATM Antibodies (360) and ATM Kits (50) and many more products for this protein. A total of 429 ATM products are currently listed.

Dna2 co-localizes in foci with RPA (show RPA1 Proteins) and is found in a complex with replication fork components And-1 and Mcm10 (show MCM10 Proteins). Dna2 interacts with the DSB repair and checkpoint proteins Nbs1 (show NLRP2 Proteins) and ATM.

These findings suggest that the MRN complex is a crucial mediator in the process whereby ATM promotes the TopBP1 (show TOPBP1 Proteins)-dependent activation of ATR-ATRIP (show ATRIP Proteins) in response to double-stranded DNA breaks.

The Fanconi anemia proteinFANCM is controlled by FANCD2 and the ATR/ATM pathways.

Zebrafish Ataxia Telangiectasia Mutated (ATM) interaction partners

molecular cloning of the coding sequence of the catalytic domain of the zebrafish homologue of ATM

Characterization of ataxia telangiectasia protein.

Human Ataxia Telangiectasia Mutated (ATM) interaction partners

Genomic profiling and exome sequencing identify ATM as a tumor suppressor gene and confirm that germline ATM mutations are involved in a subset of familial BC.

Of note is the recent U.S. Food and Drug Administration breakthrough therapy designation of olaparib for the treatment of BRCA1/2- or ATM-mutated metastatic castration-resistant prostate cancer. The implications of this new knowledge for clinical practice now and in the future are discussed.

Our results suggest the identification of ATM mutations in CLL patients with 11q deletion at diagnosis is clinically relevant and predicts disease progression, poor response to the treatment, and reduced OS independent of other molecular prognostic factors.

WSB1 (show WSB1 Proteins) is one of the key players of early oncogenic events through ATM degradation and destruction of the tumorigenesis barrier.

We conclude that an ATM-ATX axis interconnects double-strand breaks with silica-induced inflammation and propagates these effects in epithelial cells

No strong correlation was observed between ATM mutation and function. Therefore, mutation status may not be taken as an indicator of ATM function. Rather, a direct assay of the kinase activity should be used in the development of therapies.

Baf60b (show SMARCD2 Proteins), a member of the SWI/SNF chromatin remodeling complex (show SMARCA2 Proteins), links chromatin opening to ATM activation by facilitating ATM recruitment to the open chromatin regions of a panel of hepatic gene loci.

Results demonstrate that alterations in ATM levels are responsible for pronounced and anticipated GABAergic development and function. Since GABA transmission is strongly linked to the correct brain development and plasticity, this study lays basics for both a more clear comprehension of mechanisms associated with brain development.

These data indicate that defective Atm reduces the redox homeostasis of the testis and genetic integrity of sperm by regulating glutathione levels independently from G6PDH (show G6PD Proteins) activity.

WSB1 (show WSB1 Proteins) is one of the key players of early oncogenic events through ATM degradation and destruction of the tumorigenesis barrier.

ATM Protein Profile

Protein Summary

The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates\; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder.