In a dingy apartment on the Passage du Pont-Neuf in Paris, Thérèse Raquin is trapped in a loveless marriage to her sickly cousin, Camille. The numbing tedium of her life is suddenly shattered when she embarks on a turbulent affair with her husband’s earthy friend, Laurent. But their passion for each other soon compels the lovers to commit a crime that will haunt them forever.

A well-to-do French farm family is destroyed by a flood. The story, thrilling to the very end, is told from the point of view of the family's 70-year-old patriarch. The story speaks of the helplessness of mankind in the face of the forces of nature.