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You have a Dell server that you want to run Openfiler on to allow it to be an iSCSI target for your Window VM to use so that your Windows VM can have larger than a single TB disk to use instead of using a VMDK for it. Is that correct? If it is then yes you could do that however I would caution on using snapshots on the Windows VM. (I haven't read about that but I would assume that a snapshot could be potentially disastrous if you reverted to it. Suggest more research on that.)

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So assuming that your Openfiler and the Windows VM are on separate hosts I can understand why you want to do this. If they were running on the same host, then I would suggest giving the Windows VM the raw disk mapping directly.

So the answer to your original question Can you do this? The answer would be YES. The question is should you do this? I am not clear on that answer.

"If they were running on the same host, then I would suggest giving the Windows VM the raw disk mapping directly."
### yes this Openfiler is running on the ESXi server but the Windows Server that is going to use this storage is a physical server.

Ahhh. OK. Thanks for clarifying. Then yes the RDM for an Openfiler VM makes much sense and I would give it a try.

Thoughts on RDM:
-Bigger than 2TB and simpler to get going
-Little more difficult to backup Disaster Recovery image of the VM.

Thoughts on multiple VMDK's from 2 VMFS file sytems on the RAID 5 disks put together with extents in Openfiler:
-Easier portability of the OpenFiler VM to another host in future.
-Higher risk of data corruption if one disk times out, but may never be an issue.

I would rather put the extents together in OpenFiler than putting them together in Windows. If the VMDK's are all coming from the same spindles don't put the VMDKs together with a RAID 0 as that will slow things down.