A study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UKshows that “Ribosomal protein S6 kinase 1 signaling regulates mammalian life span.” This study was published, in the 2 October2009 issue of the Journal “Science” (I.F: 31.477 ), by Prof Dominic J. Withers, Dr. Selman C and others.

This study suggests, for the first time, that β-Caryophyllene, byincreasing the expression of its target gene, it may suppress Ribosomal protein S6 kinase 1 (p70S6 Kinase) expression. Thereby, it may promote: (1) resistance to bone, immune, and motor dysfunction; (2) insulin sensitivity; and (3) longevity (fig. 1).

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Fig 1. Beta-Caryophyllene may function as a longevity promoter by suppressing the expression of p70 S6 Kinase

Thus, pharmacological formulationsencompassing “β-Caryophyllene or its analogues, either alone or in combination with any of the known longevity-promoting compound(s)” may be used to extend the lifespan of an individual (fig. 1).