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\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\b\qc UNITED STATES\par\pard\plain\cf1\f51\fs20\b\qc SECURITIES AND EXCHANGE COMMISSION\par\pard\plain\cf1\f51\fs20\b\qc WASHINGTON, D.C. 20549
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\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f54\fs18\b\ql ý\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs18\b\ql QUARTERLY REPORT PURSUANT TO SECTION\~13 OR 15(d)\~OF THE SECURITIES EXCHANGE ACT OF 1934\cell{
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\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f54\fs18\b\ql ¨\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs18\b\ql TRANSITION REPORT PURSUANT TO SECTION\~13 OR 15(d)\~OF THE SECURITIES EXCHANGE ACT OF 1934\cell{
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\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\b\qc Delaware\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\qc \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\b\qc 33-0903395\cell{
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\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\b\qc 2505 Meridian Parkway, Suite\~100\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\qc \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\qc \~\cell{
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\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\b\qc Durham, North Carolina\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\qc \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\b\qc 27713\cell{
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\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\qc (Address of Principal Executive Offices)\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\qc \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\qc (Zip Code)\cell{
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{\trowd\trqc\clbrdrt\brdrs\brdrcf1\clvertalb\cellx10800\trrh298\row}}}\pard\plain\fi792\cf1\f51\fs20\qc \~\~\~\par\pard\plain\fi396\cf1\f51\fs20\ql Indicate by check mark whether the registrant: (1)\~has filed all reports required to be filed by Section\~13 or 15(d)\~of the\plain\cf1\f51\fs20\ql Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to\plain\cf1\f51\fs20\ql file such reports), and (2)\~has been subject to such filing requirements for the past 90 days.\~Yes\plain\cf1\f54\fs20\ql ý\plain\cf1\f51\fs20\ql No\plain\cf1\f54\fs20\ql ¨\par\pard\plain\fi396\cf1\f51\fs20\ql \~\par\pard\plain\fi396\cf1\f51\fs20\qj Indicate by check mark whether the registrant has submitted electronically and posted on its corporate Web site, if any, every\plain\cf1\f51\fs20\qj Interactive Data File required to be submitted and posted pursuant to Rule\~405 of Regulation S-T (\u167?232.405 of this chapter)\plain\cf1\f51\fs20\qj during the preceding 12 months (or for such shorter period that the registrant was required to submit and post such files). \~Yes\plain\cf1\f54\fs20\qj ý\plain\cf1\f51\fs20\qj \~\~No\plain\cf1\f54\fs20\qj o\par\pard\plain\fi396\cf1\f51\fs20\qj Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, or a\plain\cf1\f51\fs20\qj smaller reporting company. See the definitions of \u8220?large accelerated filer,\u8221? \u8220?accelerated filer\u8221? and\plain\cf1\f51\fs20\qj \u8220?smaller reporting company\u8221? in Rule\~12b-2 of the Exchange Act. (Check one):\par\pard\plain\fi792\cf1\f51\fs20\ql \~
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\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\qc (Do not check if a smaller reporting company)\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\qc \~\cell{
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\pard\plain\intbl\li198\ri22\sb22\sa22\ul{\field{\*\fldinst HYPERLINK \\l "s554781824217A3DDB9706612A537F00" }{\*\fldrslt\cf3\f51\fs20\ql Item 4. Controls and Procedures}}\cell\pard\plain\intbl\li22\ri22\sb22\sa22\ul{\field{\*\fldinst HYPERLINK \\l "s554781824217A3DDB9706612A537F00" }{\*\fldrslt\cf3\f51\fs20\qr 26}}\cell{
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\pard\plain\intbl\li198\ri22\sb22\sa22\ul{\field{\*\fldinst HYPERLINK \\l "s53D53D3E23E8397B3F5A661346763CA" }{\*\fldrslt\cf3\f51\fs20\ql Item 1A. Risk Factors}}\cell\pard\plain\intbl\li22\ri22\sb22\sa22\ul{\field{\*\fldinst HYPERLINK \\l "s9EC4E6764099969EFB9466129624D99" }{\*\fldrslt\cf3\f51\fs20\qr 27}}\cell{
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\pard\plain\intbl\li198\ri22\sb22\sa22\ul{\field{\*\fldinst HYPERLINK \\l "s180EDA1FD4A7CD7FAE1A6612A5DEF3B" }{\*\fldrslt\cf3\f51\fs20\ql Item 2. Unregistered Sales of Equity Securities and Use of Proceeds}}\cell\pard\plain\intbl\li22\ri22\sb22\sa22\ul{\field{\*\fldinst HYPERLINK \\l "s180EDA1FD4A7CD7FAE1A6612A5DEF3B" }{\*\fldrslt\cf3\f51\fs20\qr 53}}\cell{
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\pard\plain\intbl\li198\ri22\sb22\sa22\ul{\field{\*\fldinst HYPERLINK \\l "sE53CD5C5FD0A16722AB86612A631F77" }{\*\fldrslt\cf3\f51\fs20\ql Item 4. Mine Safety Disclosures}}\cell\pard\plain\intbl\li22\ri22\sb22\sa22\ul{\field{\*\fldinst HYPERLINK \\l "sE53CD5C5FD0A16722AB86612A631F77" }{\*\fldrslt\cf3\f51\fs20\qr 53}}\cell{
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\par\pard\plain\fs16
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\par\pard\plain\fs16\pard\plain\cf1\f51\fs20\qc 2
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\par\pard\plain\fs16{\*\bkmkstart part_1_2_1}{\*\bkmkend part_1_2_1}\par\pard\plain\cf1\f51\fs20\b\qc PART I - FINANCIAL INFORMATION\par\pard\plain\fi792\cf1\f51\fs20\qc \~{\*\bkmkstart item_1_3_1}{\*\bkmkend item_1_3_1}\par\pard\plain\cf1\f51\fs20\b\ql ITEM 1. \~\~\~\~CONSOLIDATED FINANCIAL STATEMENTS\par\pard\plain\fi792\cf1\f51\fs20\ql \~{\*\bkmkstart s80A50A6B9A593B3E5AEE6612945DAF9}{\*\bkmkend s80A50A6B9A593B3E5AEE6612945DAF9}\par\pard\plain\cf1\f51\fs20\b\qc CHIMERIX, INC.\par\pard\plain\cf1\f51\fs20\b\qc CONSOLIDATED BALANCE SHEETS\par\pard\plain\cf1\f51\fs20\b\qc (in thousands, except share and per share data)\par\pard\plain\cf1\f51\fs20\b\qc (unaudited)\plain\cf1\f51\fs20\qc \~
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\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\cf1\f51\fs20\b\qc September 30,\plain\intbl\li22\ri22\sa22\cf1\f51\fs20\b\qc 2015\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\cf1\f51\fs20\b\qc December 31,\plain\intbl\li22\ri22\sa22\cf1\f51\fs20\b\qc 2014\cell{
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\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\b\qc ASSETS\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr \~\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr \~\cell
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\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql Current assets:\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr \~\cell
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\pard\plain\intbl\li462\ri22\sb22\sa22\cf1\f51\fs20\ql Cash and cash equivalents\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\ql $\cell\pard\plain\intbl\sb22\sa22\cf1\f51\fs20\qr 44,720\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\ql $\cell\pard\plain\intbl\sb22\sa22\cf1\f51\fs20\qr 128,462\cell
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\pard\plain\intbl\li462\ri22\sb22\sa22\cf1\f51\fs20\ql Short-term investments, available-for-sale\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 176,080\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 106,114\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell{
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\pard\plain\intbl\li462\ri22\sb22\sa22\cf1\f51\fs20\ql Accounts receivable\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 525\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 106\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell{
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\pard\plain\intbl\li462\ri22\sb22\sa22\cf1\f51\fs20\ql Prepaid expenses and other current assets\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 8,183\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 2,775\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell{
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\pard\plain\intbl\li726\ri22\sb22\sa22\cf1\f51\fs20\ql Total current assets\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 229,508\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 237,457\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7113\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7216\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx8660\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx8974\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9077\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10502\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10797\trrh281\row}}}
{\trowd\clvertalb\cellx7113\clvertalb\cellx7216\clvertalb\cellx8660\clvertalb\cellx8974\clvertalb\cellx9077\clvertalb\cellx10502\clvertalb\cellx10797\trrh281
\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql Long-term investments\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 159,486\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 52,973\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalb\cellx7113\clvertalb\cellx7216\clvertalb\cellx8660\clvertalb\cellx8974\clvertalb\cellx9077\clvertalb\cellx10502\clvertalb\cellx10797\trrh281\row}}}
{\trowd\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7113\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7216\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx8660\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx8974\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9077\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10502\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10797\trrh281
\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql Property and equipment, net of accumulated depreciation\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 2,439\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 1,310\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7113\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7216\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx8660\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx8974\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9077\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10502\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10797\trrh281\row}}}
{\trowd\clvertalb\cellx7113\clvertalb\cellx7216\clbrdrb\brdrs\brdrcf1\clvertalb\cellx8660\clbrdrb\brdrs\brdrcf1\clvertalb\cellx8974\clvertalb\cellx9077\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10502\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10797\trrh281
\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql Other long-term assets\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 75\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 138\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalb\cellx7113\clvertalb\cellx7216\clbrdrb\brdrs\brdrcf1\clvertalb\cellx8660\clbrdrb\brdrs\brdrcf1\clvertalb\cellx8974\clvertalb\cellx9077\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10502\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10797\trrh281\row}}}
{\trowd\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7113\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7216\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7530\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx8660\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx8974\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9077\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9372\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10502\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10797\trrh281
\pard\plain\intbl\li858\ri22\sb22\sa22\cf1\f51\fs20\ql Total assets\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\ql $\cell\pard\plain\intbl\sb22\sa22\cf1\f51\fs20\qr 391,508\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\ql $\cell\pard\plain\intbl\sb22\sa22\cf1\f51\fs20\qr 291,878\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7113\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7216\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7530\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx8660\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx8974\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9077\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9372\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10502\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10797\trrh281\row}}}
{\trowd\clvertalb\cellx7113\clvertalb\cellx7216\clvertalb\cellx8974\clvertalb\cellx9077\clvertalb\cellx10798\trrh338
\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell{
{\trowd\clvertalb\cellx7113\clvertalb\cellx7216\clvertalb\cellx8974\clvertalb\cellx9077\clvertalb\cellx10798\trrh338\row}}}
{\trowd\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7113\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7216\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx8660\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx8974\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9077\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10502\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10797\trrh281
\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\b\qc LIABILITIES AND STOCKHOLDERS' EQUITY\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr \~\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr \~\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7113\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7216\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx8660\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx8974\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9077\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10502\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10797\trrh281\row}}}
{\trowd\clvertalb\cellx7113\clvertalb\cellx7216\clvertalb\cellx8660\clvertalb\cellx8974\clvertalb\cellx9077\clvertalb\cellx10502\clvertalb\cellx10797\trrh281
\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql Current liabilities:\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr \~\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr \~\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalb\cellx7113\clvertalb\cellx7216\clvertalb\cellx8660\clvertalb\cellx8974\clvertalb\cellx9077\clvertalb\cellx10502\clvertalb\cellx10797\trrh281\row}}}
{\trowd\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7113\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7216\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7530\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx8660\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx8974\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9077\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9372\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10502\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10797\trrh281
\pard\plain\intbl\li462\ri22\sb22\sa22\cf1\f51\fs20\ql Accounts payable\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\ql $\cell\pard\plain\intbl\sb22\sa22\cf1\f51\fs20\qr 12,919\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\ql $\cell\pard\plain\intbl\sb22\sa22\cf1\f51\fs20\qr 5,938\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7113\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7216\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7530\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx8660\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx8974\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9077\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9372\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10502\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10797\trrh281\row}}}
{\trowd\clvertalb\cellx7113\clvertalb\cellx7216\clvertalb\cellx8660\clvertalb\cellx8974\clvertalb\cellx9077\clvertalb\cellx10502\clvertalb\cellx10797\trrh281
\pard\plain\intbl\li462\ri22\sb22\sa22\cf1\f51\fs20\ql Accrued liabilities\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 7,782\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 6,833\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalb\cellx7113\clvertalb\cellx7216\clvertalb\cellx8660\clvertalb\cellx8974\clvertalb\cellx9077\clvertalb\cellx10502\clvertalb\cellx10797\trrh281\row}}}
{\trowd\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7113\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7216\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx8660\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx8974\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9077\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10502\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10797\trrh281
\pard\plain\intbl\li462\ri22\sb22\sa22\cf1\f51\fs20\ql Loan payable, net\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 375\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 4,296\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7113\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7216\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx8660\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx8974\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9077\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10502\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10797\trrh281\row}}}
{\trowd\clvertalb\cellx7113\clvertalb\cellx7216\clvertalb\cellx8660\clvertalb\cellx8974\clvertalb\cellx9077\clvertalb\cellx10502\clvertalb\cellx10797\trrh281
\pard\plain\intbl\li726\ri22\sb22\sa22\cf1\f51\fs20\ql Total current liabilities\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 21,076\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 17,067\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalb\cellx7113\clvertalb\cellx7216\clvertalb\cellx8660\clvertalb\cellx8974\clvertalb\cellx9077\clvertalb\cellx10502\clvertalb\cellx10797\trrh281\row}}}
{\trowd\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7113\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7216\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8660\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8974\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9077\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10502\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10797\trrh281
\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql Long-term liabilities\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 221\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 175\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7113\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7216\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8660\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8974\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9077\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10502\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10797\trrh281\row}}}
{\trowd\clvertalb\cellx7113\clvertalb\cellx7216\clvertalb\cellx8660\clvertalb\cellx8974\clvertalb\cellx9077\clvertalb\cellx10502\clvertalb\cellx10797\trrh281
\pard\plain\intbl\li858\ri22\sb22\sa22\cf1\f51\fs20\ql Total liabilities\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 21,297\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 17,242\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalb\cellx7113\clvertalb\cellx7216\clvertalb\cellx8660\clvertalb\cellx8974\clvertalb\cellx9077\clvertalb\cellx10502\clvertalb\cellx10797\trrh281\row}}}
{\trowd\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7113\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7216\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8974\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9077\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10798\trrh281
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell{
{\trowd\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7113\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7216\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8974\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9077\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10798\trrh281\row}}}
{\trowd\clvertalb\cellx7113\clvertalb\cellx7216\clvertalb\cellx8660\clvertalb\cellx8974\clvertalb\cellx9077\clvertalb\cellx10502\clvertalb\cellx10797\trrh281
\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql Commitments and contingencies\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr \u8212?\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr \u8212?\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalb\cellx7113\clvertalb\cellx7216\clvertalb\cellx8660\clvertalb\cellx8974\clvertalb\cellx9077\clvertalb\cellx10502\clvertalb\cellx10797\trrh281\row}}}
{\trowd\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7113\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7216\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8974\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9077\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10798\trrh338
\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell{
{\trowd\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7113\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7216\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8974\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9077\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10798\trrh338\row}}}
{\trowd\clvertalb\cellx7113\clvertalb\cellx7216\clvertalb\cellx8660\clvertalb\cellx8974\clvertalb\cellx9077\clvertalb\cellx10502\clvertalb\cellx10797\trrh281
\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql Stockholders\u8217? equity:\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr \~\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr \~\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalb\cellx7113\clvertalb\cellx7216\clvertalb\cellx8660\clvertalb\cellx8974\clvertalb\cellx9077\clvertalb\cellx10502\clvertalb\cellx10797\trrh281\row}}}
{\trowd\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7113\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7216\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8660\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8974\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9077\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10502\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10797\trrh776
\pard\plain\intbl\li198\ri22\sb22\fi-88\cf1\f51\fs20\ql Preferred stock, $0.001 par value, 10,000,000 shares authorized at September\plain\intbl\li198\ri22\cf1\f51\fs20\ql 30, 2015 and December 31, 2014; no shares issued and outstanding as of\plain\intbl\li198\ri22\sa22\cf1\f51\fs20\ql September 30, 2015 and December 31, 2014\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr \u8212?\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr \u8212?\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7113\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7216\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8660\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8974\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9077\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10502\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10797\trrh776\row}}}
{\trowd\clvertalb\cellx7113\clvertalb\cellx7216\clvertalb\cellx8660\clvertalb\cellx8974\clvertalb\cellx9077\clvertalb\cellx10502\clvertalb\cellx10797\trrh1024
\pard\plain\intbl\li198\ri22\sb22\fi-88\cf1\f51\fs20\ql Common stock, $0.001 par value, 200,000,000 shares authorized at September\plain\intbl\li198\ri22\cf1\f51\fs20\ql 30, 2015 and December 31, 2014; 46,142,340 and 41,031,770 shares issued\plain\intbl\li198\ri22\cf1\f51\fs20\ql and outstanding as of September 30, 2015 and December 31, 2014,\plain\intbl\li198\ri22\sa22\cf1\f51\fs20\ql respectively\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 46\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 41\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalb\cellx7113\clvertalb\cellx7216\clvertalb\cellx8660\clvertalb\cellx8974\clvertalb\cellx9077\clvertalb\cellx10502\clvertalb\cellx10797\trrh1024\row}}}
{\trowd\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7113\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7216\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8660\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8974\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9077\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10502\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10797\trrh281
\pard\plain\intbl\li462\ri22\sb22\sa22\cf1\f51\fs20\ql Additional paid-in capital\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 671,380\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 496,602\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7113\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7216\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8660\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8974\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9077\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10502\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10797\trrh281\row}}}
{\trowd\clvertalb\cellx7113\clvertalb\cellx7216\clvertalb\cellx8660\clvertalb\cellx8974\clvertalb\cellx9077\clvertalb\cellx10502\clvertalb\cellx10797\trrh281
\pard\plain\intbl\li462\ri22\sb22\sa22\cf1\f51\fs20\ql Accumulated other comprehensive gain, net\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 356\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 35\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalb\cellx7113\clvertalb\cellx7216\clvertalb\cellx8660\clvertalb\cellx8974\clvertalb\cellx9077\clvertalb\cellx10502\clvertalb\cellx10797\trrh281\row}}}
{\trowd\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7113\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7216\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8660\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8974\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9077\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10502\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10797\trrh281
\pard\plain\intbl\li462\ri22\sb22\sa22\cf1\f51\fs20\ql Accumulated deficit\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr (301,571\cell\pard\plain\intbl\ri22\sb22\sa22\cf1\f51\fs20\ql )\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr (222,042\cell\pard\plain\intbl\ri22\sb22\sa22\cf1\f51\fs20\ql )\cell{
{\trowd\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7113\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7216\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8660\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8974\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9077\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10502\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10797\trrh281\row}}}
{\trowd\clvertalb\cellx7113\clvertalb\cellx7216\clbrdrb\brdrs\brdrcf1\clvertalb\cellx8660\clbrdrb\brdrs\brdrcf1\clvertalb\cellx8974\clvertalb\cellx9077\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10502\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10797\trrh281
\pard\plain\intbl\li858\ri22\sb22\sa22\cf1\f51\fs20\ql Total stockholders\u8217? equity\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 370,211\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 274,636\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalb\cellx7113\clvertalb\cellx7216\clbrdrb\brdrs\brdrcf1\clvertalb\cellx8660\clbrdrb\brdrs\brdrcf1\clvertalb\cellx8974\clvertalb\cellx9077\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10502\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10797\trrh281\row}}}
{\trowd\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7113\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7216\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7530\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8660\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8974\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9077\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9372\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10502\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10797\trrh281
\pard\plain\intbl\li990\ri22\sb22\sa22\cf1\f51\fs20\ql Total liabilities and stockholders\u8217? equity\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\ql $\cell\pard\plain\intbl\sb22\sa22\cf1\f51\fs20\qr 391,508\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\ql $\cell\pard\plain\intbl\sb22\sa22\cf1\f51\fs20\qr 291,878\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7113\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7216\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7530\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8660\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8974\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9077\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9372\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10502\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10797\trrh281\row}}}\pard\plain\fi792\cf1\f51\fs20\qc \~\par\pard\plain\cf1\f51\fs20\qc The accompanying notes are an integral part of the consolidated financial statements.
\par\pard\plain\fs16
\par\pard\plain\fs16
\par\pard\plain\fs16
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qc 3
\par\pard\plain\fs16\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par
\page{\*\bkmkstart s0F2C464F60A7C99375C5661293DD32A}{\*\bkmkend s0F2C464F60A7C99375C5661293DD32A}
\par\pard\plain\fs16
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\b\qc CHIMERIX, INC.\par\pard\plain\cf1\f51\fs20\b\qc CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS\par\pard\plain\cf1\f51\fs20\b\qc (in thousands, except share and per share data)\par\pard\plain\cf1\f51\fs20\b\qc (unaudited)
\par\pard\plain
{\trowd\clvertalc\cellx10800\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx10800\trrh-66\row}}}
{\trowd\clvertalc\cellx4332\clvertalc\cellx4435\clvertalc\cellx4661\clvertalc\cellx5784\clvertalc\cellx5928\clvertalc\cellx6072\clvertalc\cellx6298\clvertalc\cellx7421\clvertalc\cellx7565\clvertalc\cellx7668\clvertalc\cellx7887\clvertalc\cellx9011\clvertalc\cellx9155\clvertalc\cellx9299\clvertalc\cellx9525\clvertalc\cellx10648\clvertalc\cellx10792\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx4332\clvertalc\cellx4435\clvertalc\cellx4661\clvertalc\cellx5784\clvertalc\cellx5928\clvertalc\cellx6072\clvertalc\cellx6298\clvertalc\cellx7421\clvertalc\cellx7565\clvertalc\cellx7668\clvertalc\cellx7887\clvertalc\cellx9011\clvertalc\cellx9155\clvertalc\cellx9299\clvertalc\cellx9525\clvertalc\cellx10648\clvertalc\cellx10792\trrh-66\row}}}
{\trowd\clvertalb\cellx4332\clvertalb\cellx4435\clbrdrb\brdrs\brdrcf1\clvertalb\cellx7568\clvertalb\cellx7671\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10798\trrh529
\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\cf1\f51\fs20\b\qc Three Months Ended September\plain\intbl\li22\sa22\cf1\f51\fs20\b\qc 30,\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\b\qc Nine Months Ended September 30,\cell{
{\trowd\clvertalb\cellx4332\clvertalb\cellx4435\clbrdrb\brdrs\brdrcf1\clvertalb\cellx7568\clvertalb\cellx7671\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10798\trrh529\row}}}
{\trowd\clvertalb\cellx4332\clvertalb\cellx4435\clbrdrb\brdrs\brdrcf1\clvertalb\cellx5929\clvertalb\cellx6073\clbrdrb\brdrs\brdrcf1\clvertalb\cellx7567\clvertalb\cellx7670\clbrdrb\brdrs\brdrcf1\clvertalb\cellx9158\clvertalb\cellx9302\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10796\trrh281
\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\b\qc 2015\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\b\qc 2014\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\b\qc 2015\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\b\qc 2014\cell{
{\trowd\clvertalb\cellx4332\clvertalb\cellx4435\clbrdrb\brdrs\brdrcf1\clvertalb\cellx5929\clvertalb\cellx6073\clbrdrb\brdrs\brdrcf1\clvertalb\cellx7567\clvertalb\cellx7670\clbrdrb\brdrs\brdrcf1\clvertalb\cellx9158\clvertalb\cellx9302\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10796\trrh281\row}}}
{\trowd\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx4332\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx4435\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx5785\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx5929\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx6073\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7423\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7567\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7670\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9013\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9157\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9301\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10651\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10795\trrh281
\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\b\ql Revenues:\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr \~\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr \~\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr \~\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr \~\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx4332\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx4435\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx5785\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx5929\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx6073\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7423\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7567\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7670\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9013\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9157\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9301\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10651\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10795\trrh281\row}}}
{\trowd\clvertalb\cellx4332\clvertalb\cellx4435\clvertalb\cellx4661\clvertalb\cellx5784\clvertalb\cellx5928\clvertalb\cellx6072\clvertalb\cellx6298\clvertalb\cellx7421\clvertalb\cellx7565\clvertalb\cellx7668\clvertalb\cellx7887\clvertalb\cellx9011\clvertalb\cellx9155\clvertalb\cellx9299\clvertalb\cellx9525\clvertalb\cellx10648\clvertalb\cellx10792\trrh281
\pard\plain\intbl\li330\ri22\sb22\sa22\cf1\f51\fs20\ql Contract revenue\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\ql $\cell\pard\plain\intbl\sb22\sa22\cf1\f51\fs20\qr 2,271\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\ql $\cell\pard\plain\intbl\sb22\sa22\cf1\f51\fs20\qr 1,185\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\ql $\cell\pard\plain\intbl\sb22\sa22\cf1\f51\fs20\qr 6,104\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\ql $\cell\pard\plain\intbl\sb22\sa22\cf1\f51\fs20\qr 2,884\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalb\cellx4332\clvertalb\cellx4435\clvertalb\cellx4661\clvertalb\cellx5784\clvertalb\cellx5928\clvertalb\cellx6072\clvertalb\cellx6298\clvertalb\cellx7421\clvertalb\cellx7565\clvertalb\cellx7668\clvertalb\cellx7887\clvertalb\cellx9011\clvertalb\cellx9155\clvertalb\cellx9299\clvertalb\cellx9525\clvertalb\cellx10648\clvertalb\cellx10792\trrh281\row}}}
{\trowd\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx4332\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx4435\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx5785\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx5929\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx6073\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7423\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7567\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7670\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9013\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9157\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9301\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10651\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10795\trrh281
\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\~\~\~\~Collaboration and licensing revenue\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr \u8212?\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr \u8212?\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 1,548\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr \u8212?\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx4332\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx4435\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx5785\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx5929\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx6073\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7423\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7567\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7670\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9013\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9157\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9301\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10651\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10795\trrh281\row}}}
{\trowd\clvertalb\cellx4332\clvertalb\cellx4435\clvertalb\cellx5785\clvertalb\cellx5929\clvertalb\cellx6073\clvertalb\cellx7423\clvertalb\cellx7567\clvertalb\cellx7670\clvertalb\cellx9013\clvertalb\cellx9157\clvertalb\cellx9301\clvertalb\cellx10651\clvertalb\cellx10795\trrh281
\pard\plain\intbl\li594\ri22\sb22\sa22\cf1\f51\fs20\ql Total revenues\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 2,271\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 1,185\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 7,652\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 2,884\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalb\cellx4332\clvertalb\cellx4435\clvertalb\cellx5785\clvertalb\cellx5929\clvertalb\cellx6073\clvertalb\cellx7423\clvertalb\cellx7567\clvertalb\cellx7670\clvertalb\cellx9013\clvertalb\cellx9157\clvertalb\cellx9301\clvertalb\cellx10651\clvertalb\cellx10795\trrh281\row}}}
{\trowd\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx4332\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx4435\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx5785\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx5929\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx6073\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7423\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7567\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7670\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9013\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9157\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9301\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10651\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10795\trrh281
\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\b\ql Operating expenses:\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr \~\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr \~\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr \~\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr \~\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx4332\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx4435\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx5785\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx5929\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx6073\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7423\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7567\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7670\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9013\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9157\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9301\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10651\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10795\trrh281\row}}}
{\trowd\clvertalb\cellx4332\clvertalb\cellx4435\clvertalb\cellx5785\clvertalb\cellx5929\clvertalb\cellx6073\clvertalb\cellx7423\clvertalb\cellx7567\clvertalb\cellx7670\clvertalb\cellx9013\clvertalb\cellx9157\clvertalb\cellx9301\clvertalb\cellx10651\clvertalb\cellx10795\trrh281
\pard\plain\intbl\li330\ri22\sb22\sa22\cf1\f51\fs20\ql Research and development\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 26,406\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 13,328\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 65,611\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 29,712\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalb\cellx4332\clvertalb\cellx4435\clvertalb\cellx5785\clvertalb\cellx5929\clvertalb\cellx6073\clvertalb\cellx7423\clvertalb\cellx7567\clvertalb\cellx7670\clvertalb\cellx9013\clvertalb\cellx9157\clvertalb\cellx9301\clvertalb\cellx10651\clvertalb\cellx10795\trrh281\row}}}
{\trowd\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx4332\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx4435\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx5785\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx5929\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx6073\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7423\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7567\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7670\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9013\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9157\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9301\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10651\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10795\trrh281
\pard\plain\intbl\li330\ri22\sb22\sa22\cf1\f51\fs20\ql General and administrative\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 8,613\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 4,717\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 22,068\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 11,812\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx4332\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx4435\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx5785\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx5929\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx6073\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7423\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7567\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7670\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9013\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9157\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9301\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10651\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10795\trrh281\row}}}
{\trowd\clvertalb\cellx4332\clvertalb\cellx4435\clbrdrb\brdrs\brdrcf1\clvertalb\cellx5785\clbrdrb\brdrs\brdrcf1\clvertalb\cellx5929\clvertalb\cellx6073\clbrdrb\brdrs\brdrcf1\clvertalb\cellx7423\clbrdrb\brdrs\brdrcf1\clvertalb\cellx7567\clvertalb\cellx7670\clbrdrb\brdrs\brdrcf1\clvertalb\cellx9013\clbrdrb\brdrs\brdrcf1\clvertalb\cellx9157\clvertalb\cellx9301\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10651\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10795\trrh281
\pard\plain\intbl\li594\ri22\sb22\sa22\cf1\f51\fs20\ql Total operating expenses\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 35,019\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 18,045\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 87,679\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 41,524\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalb\cellx4332\clvertalb\cellx4435\clbrdrb\brdrs\brdrcf1\clvertalb\cellx5785\clbrdrb\brdrs\brdrcf1\clvertalb\cellx5929\clvertalb\cellx6073\clbrdrb\brdrs\brdrcf1\clvertalb\cellx7423\clbrdrb\brdrs\brdrcf1\clvertalb\cellx7567\clvertalb\cellx7670\clbrdrb\brdrs\brdrcf1\clvertalb\cellx9013\clbrdrb\brdrs\brdrcf1\clvertalb\cellx9157\clvertalb\cellx9301\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10651\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10795\trrh281\row}}}
{\trowd\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx4332\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx4435\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx5785\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx5929\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx6073\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7423\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7567\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7670\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9013\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9157\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9301\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10651\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10795\trrh281
\pard\plain\intbl\li858\ri22\sb22\sa22\cf1\f51\fs20\ql Loss from operations\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr (32,748\cell\pard\plain\intbl\ri22\sb22\sa22\cf1\f51\fs20\ql )\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr (16,860\cell\pard\plain\intbl\ri22\sb22\sa22\cf1\f51\fs20\ql )\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr (80,027\cell\pard\plain\intbl\ri22\sb22\sa22\cf1\f51\fs20\ql )\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr (38,640\cell\pard\plain\intbl\ri22\sb22\sa22\cf1\f51\fs20\ql )\cell{
{\trowd\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx4332\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx4435\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx5785\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx5929\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx6073\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7423\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7567\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7670\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9013\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9157\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9301\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10651\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10795\trrh281\row}}}
{\trowd\clvertalb\cellx4332\clvertalb\cellx4435\clvertalb\cellx5785\clvertalb\cellx5929\clvertalb\cellx6073\clvertalb\cellx7423\clvertalb\cellx7567\clvertalb\cellx7670\clvertalb\cellx9013\clvertalb\cellx9157\clvertalb\cellx9301\clvertalb\cellx10651\clvertalb\cellx10795\trrh281
\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\b\ql Other income (expense):\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr \~\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr \~\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr \~\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr \~\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalb\cellx4332\clvertalb\cellx4435\clvertalb\cellx5785\clvertalb\cellx5929\clvertalb\cellx6073\clvertalb\cellx7423\clvertalb\cellx7567\clvertalb\cellx7670\clvertalb\cellx9013\clvertalb\cellx9157\clvertalb\cellx9301\clvertalb\cellx10651\clvertalb\cellx10795\trrh281\row}}}
{\trowd\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx4332\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx4435\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx5785\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx5929\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx6073\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7423\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7567\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7670\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9013\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9157\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9301\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10651\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10795\trrh281
\pard\plain\intbl\li330\ri22\sb22\sa22\cf1\f51\fs20\ql Interest income (expense), net\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 299\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr (91\cell\pard\plain\intbl\ri22\sb22\sa22\cf1\f51\fs20\ql )\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 498\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr (425\cell\pard\plain\intbl\ri22\sb22\sa22\cf1\f51\fs20\ql )\cell{
{\trowd\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx4332\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx4435\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx5785\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx5929\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx6073\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7423\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7567\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7670\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9013\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9157\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9301\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10651\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10795\trrh281\row}}}
{\trowd\clvertalb\cellx4332\clvertalb\cellx4435\clbrdrt\brdrs\brdrcf1\clvertalb\cellx5785\clbrdrt\brdrs\brdrcf1\clvertalb\cellx5929\clvertalb\cellx6073\clbrdrt\brdrs\brdrcf1\clvertalb\cellx7423\clbrdrt\brdrs\brdrcf1\clvertalb\cellx7567\clvertalb\cellx7670\clbrdrt\brdrs\brdrcf1\clvertalb\cellx9013\clbrdrt\brdrs\brdrcf1\clvertalb\cellx9157\clvertalb\cellx9301\clbrdrt\brdrs\brdrcf1\clvertalb\cellx10651\clbrdrt\brdrs\brdrcf1\clvertalb\cellx10795\trrh298
\pard\plain\intbl\li858\ri22\sb22\sa22\cf1\f51\fs20\b\ql Net loss\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr (32,449\cell\pard\plain\intbl\ri22\sb22\sa22\cf1\f51\fs20\ql )\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr (16,951\cell\pard\plain\intbl\ri22\sb22\sa22\cf1\f51\fs20\ql )\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr (79,529\cell\pard\plain\intbl\ri22\sb22\sa22\cf1\f51\fs20\ql )\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr (39,065\cell\pard\plain\intbl\ri22\sb22\sa22\cf1\f51\fs20\ql )\cell{
{\trowd\clvertalb\cellx4332\clvertalb\cellx4435\clbrdrt\brdrs\brdrcf1\clvertalb\cellx5785\clbrdrt\brdrs\brdrcf1\clvertalb\cellx5929\clvertalb\cellx6073\clbrdrt\brdrs\brdrcf1\clvertalb\cellx7423\clbrdrt\brdrs\brdrcf1\clvertalb\cellx7567\clvertalb\cellx7670\clbrdrt\brdrs\brdrcf1\clvertalb\cellx9013\clbrdrt\brdrs\brdrcf1\clvertalb\cellx9157\clvertalb\cellx9301\clbrdrt\brdrs\brdrcf1\clvertalb\cellx10651\clbrdrt\brdrs\brdrcf1\clvertalb\cellx10795\trrh298\row}}}
{\trowd\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx4332\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx4435\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx5785\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx5929\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx6073\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7423\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7567\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7670\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9013\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9157\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9301\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10651\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10795\trrh281
\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\b\ql Other comprehensive loss:\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr \~\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr \~\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr \~\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr \~\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx4332\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx4435\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx5785\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx5929\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx6073\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7423\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7567\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7670\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9013\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9157\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9301\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10651\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10795\trrh281\row}}}
{\trowd\clvertalb\cellx4332\clvertalb\cellx4435\clbrdrb\brdrs\brdrcf1\clvertalb\cellx5785\clbrdrb\brdrs\brdrcf1\clvertalb\cellx5929\clvertalb\cellx6073\clbrdrb\brdrs\brdrcf1\clvertalb\cellx7423\clbrdrb\brdrs\brdrcf1\clvertalb\cellx7567\clvertalb\cellx7670\clbrdrb\brdrs\brdrcf1\clvertalb\cellx9013\clbrdrb\brdrs\brdrcf1\clvertalb\cellx9157\clvertalb\cellx9301\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10651\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10795\trrh281
\pard\plain\intbl\li330\ri22\sb22\sa22\cf1\f51\fs20\ql Unrealized (loss) gain on investments, net\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr (1,448\cell\pard\plain\intbl\ri22\sb22\sa22\cf1\f51\fs20\ql )\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr (43\cell\pard\plain\intbl\ri22\sb22\sa22\cf1\f51\fs20\ql )\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 321\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr (63\cell\pard\plain\intbl\ri22\sb22\sa22\cf1\f51\fs20\ql )\cell{
{\trowd\clvertalb\cellx4332\clvertalb\cellx4435\clbrdrb\brdrs\brdrcf1\clvertalb\cellx5785\clbrdrb\brdrs\brdrcf1\clvertalb\cellx5929\clvertalb\cellx6073\clbrdrb\brdrs\brdrcf1\clvertalb\cellx7423\clbrdrb\brdrs\brdrcf1\clvertalb\cellx7567\clvertalb\cellx7670\clbrdrb\brdrs\brdrcf1\clvertalb\cellx9013\clbrdrb\brdrs\brdrcf1\clvertalb\cellx9157\clvertalb\cellx9301\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10651\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10795\trrh281\row}}}
{\trowd\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx4332\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx4435\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx4661\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx5784\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx5928\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx6072\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx6298\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7421\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7565\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7668\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7887\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9011\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9155\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9299\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9525\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10648\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10792\trrh281
\pard\plain\intbl\li858\ri22\sb22\sa22\cf1\f51\fs20\ql Comprehensive loss\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\ql $\cell\pard\plain\intbl\sb22\sa22\cf1\f51\fs20\qr (33,897\cell\pard\plain\intbl\ri22\sb22\sa22\cf1\f51\fs20\ql )\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\ql $\cell\pard\plain\intbl\sb22\sa22\cf1\f51\fs20\qr (16,994\cell\pard\plain\intbl\ri22\sb22\sa22\cf1\f51\fs20\ql )\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\ql $\cell\pard\plain\intbl\sb22\sa22\cf1\f51\fs20\qr (79,208\cell\pard\plain\intbl\ri22\sb22\sa22\cf1\f51\fs20\ql )\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\ql $\cell\pard\plain\intbl\sb22\sa22\cf1\f51\fs20\qr (39,128\cell\pard\plain\intbl\ri22\sb22\sa22\cf1\f51\fs20\ql )\cell{
{\trowd\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx4332\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx4435\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx4661\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx5784\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx5928\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx6072\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx6298\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7421\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7565\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7668\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7887\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9011\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9155\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9299\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9525\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10648\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10792\trrh281\row}}}
{\trowd\clvertalb\cellx4332\clvertalb\cellx4435\clvertalb\cellx5785\clvertalb\cellx5929\clvertalb\cellx6073\clvertalb\cellx7423\clvertalb\cellx7567\clvertalb\cellx7670\clvertalb\cellx9013\clvertalb\cellx9157\clvertalb\cellx9301\clvertalb\cellx10651\clvertalb\cellx10795\trrh281
\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\b\ql Per share information:\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr \~\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr \~\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr \~\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr \~\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalb\cellx4332\clvertalb\cellx4435\clvertalb\cellx5785\clvertalb\cellx5929\clvertalb\cellx6073\clvertalb\cellx7423\clvertalb\cellx7567\clvertalb\cellx7670\clvertalb\cellx9013\clvertalb\cellx9157\clvertalb\cellx9301\clvertalb\cellx10651\clvertalb\cellx10795\trrh281\row}}}
{\trowd\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx4332\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx4435\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx4661\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx5784\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx5928\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx6072\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx6298\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7421\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7565\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7668\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7887\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9011\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9155\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9299\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9525\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10648\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10792\trrh281
\pard\plain\intbl\li330\ri22\sb22\sa22\cf1\f51\fs20\ql Net loss, basic and diluted\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\ql $\cell\pard\plain\intbl\sb22\sa22\cf1\f51\fs20\qr (0.70\cell\pard\plain\intbl\ri22\sb22\sa22\cf1\f51\fs20\ql )\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\ql $\cell\pard\plain\intbl\sb22\sa22\cf1\f51\fs20\qr (0.47\cell\pard\plain\intbl\ri22\sb22\sa22\cf1\f51\fs20\ql )\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\ql $\cell\pard\plain\intbl\sb22\sa22\cf1\f51\fs20\qr (1.84\cell\pard\plain\intbl\ri22\sb22\sa22\cf1\f51\fs20\ql )\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\ql $\cell\pard\plain\intbl\sb22\sa22\cf1\f51\fs20\qr (1.26\cell\pard\plain\intbl\ri22\sb22\sa22\cf1\f51\fs20\ql )\cell{
{\trowd\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx4332\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx4435\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx4661\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx5784\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx5928\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx6072\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx6298\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7421\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7565\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7668\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7887\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9011\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9155\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9299\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9525\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10648\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10792\trrh281\row}}}
{\trowd\clvertalb\cellx4332\clvertalb\cellx4435\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx5785\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx5929\clvertalb\cellx6073\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx7423\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx7567\clvertalb\cellx7670\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx9013\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx9157\clvertalb\cellx9301\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx10651\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx10795\trrh529
\pard\plain\intbl\li330\ri22\sb22\cf1\f51\fs20\ql Weighted-average shares outstanding, basic and\plain\intbl\li330\ri22\sa22\cf1\f51\fs20\ql diluted\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 46,059,112\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 35,845,792\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 43,112,314\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 30,939,752\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalb\cellx4332\clvertalb\cellx4435\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx5785\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx5929\clvertalb\cellx6073\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx7423\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx7567\clvertalb\cellx7670\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx9013\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx9157\clvertalb\cellx9301\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx10651\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx10795\trrh529\row}}}\pard\plain\fi792\cf1\f51\fs20\ql \~\~\par\pard\plain\cf1\f51\fs20\qc The accompanying notes are an integral part of the consolidated financial statements.
\par\pard\plain\fs16\par\pard\plain\fi792\cf1\f51\fs20\qc \~
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qc 4
\par\pard\plain\fs16\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par
\page{\*\bkmkstart sB5C5CFD9877D2F342E556612947FBC8}{\*\bkmkend sB5C5CFD9877D2F342E556612947FBC8}
\par\pard\plain\fs16
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\b\qc CHIMERIX, INC.\par\pard\plain\cf1\f51\fs20\b\qc CONSOLIDATED STATEMENTS OF CASH FLOWS\par\pard\plain\cf1\f51\fs20\b\qc (in thousands)\par\pard\plain\cf1\f51\fs20\b\qc (unaudited)\plain\cf1\f51\fs20\qc \~
\par\pard\plain
{\trowd\clvertalc\cellx10800\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx10800\trrh-66\row}}}
{\trowd\clvertalc\cellx7621\clvertalc\cellx7728\clvertalc\cellx7872\clvertalc\cellx9046\clvertalc\cellx9190\clvertalc\cellx9334\clvertalc\cellx9478\clvertalc\cellx10652\clvertalc\cellx10796\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx7621\clvertalc\cellx7728\clvertalc\cellx7872\clvertalc\cellx9046\clvertalc\cellx9190\clvertalc\cellx9334\clvertalc\cellx9478\clvertalc\cellx10652\clvertalc\cellx10796\trrh-66\row}}}
{\trowd\clvertalb\cellx7621\clvertalb\cellx7728\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10799\trrh529
\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\cf1\f51\fs20\b\qc Nine Months Ended September\plain\intbl\li22\sa22\cf1\f51\fs20\b\qc 30,\cell{
{\trowd\clvertalb\cellx7621\clvertalb\cellx7728\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10799\trrh529\row}}}
{\trowd\clvertalb\cellx7621\clvertalb\cellx7728\clbrdrb\brdrs\brdrcf1\clvertalb\cellx9191\clvertalb\cellx9335\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10798\trrh281
\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\b\qc 2015\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\b\qc 2014\cell{
{\trowd\clvertalb\cellx7621\clvertalb\cellx7728\clbrdrb\brdrs\brdrcf1\clvertalb\cellx9191\clvertalb\cellx9335\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10798\trrh281\row}}}
{\trowd\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7621\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7728\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9046\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9190\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9334\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10652\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10796\trrh281
\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\b\ql Cash flows from operating activities:\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr \~\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr \~\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7621\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7728\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9046\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9190\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9334\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10652\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10796\trrh281\row}}}
{\trowd\clvertalb\cellx7621\clvertalb\cellx7728\clvertalb\cellx7872\clvertalb\cellx9046\clvertalb\cellx9190\clvertalb\cellx9334\clvertalb\cellx9478\clvertalb\cellx10652\clvertalb\cellx10796\trrh281
\pard\plain\intbl\li330\ri22\sb22\sa22\cf1\f51\fs20\ql Net loss\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\ql $\cell\pard\plain\intbl\sb22\sa22\cf1\f51\fs20\qr (79,529\cell\pard\plain\intbl\ri22\sb22\sa22\cf1\f51\fs20\ql )\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\ql $\cell\pard\plain\intbl\sb22\sa22\cf1\f51\fs20\qr (39,065\cell\pard\plain\intbl\ri22\sb22\sa22\cf1\f51\fs20\ql )\cell{
{\trowd\clvertalb\cellx7621\clvertalb\cellx7728\clvertalb\cellx7872\clvertalb\cellx9046\clvertalb\cellx9190\clvertalb\cellx9334\clvertalb\cellx9478\clvertalb\cellx10652\clvertalb\cellx10796\trrh281\row}}}
{\trowd\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7621\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7728\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9046\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9190\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9334\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10652\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10796\trrh281
\pard\plain\intbl\li330\ri22\sb22\sa22\cf1\f51\fs20\ql Adjustments to reconcile net loss to net cash used in operating activities:\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr \~\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr \~\cell
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\pard\plain\intbl\li594\ri22\sb22\sa22\cf1\f51\fs20\ql Depreciation of property and equipment\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 444\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 183\cell
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\pard\plain\intbl\li594\ri22\sb22\sa22\cf1\f51\fs20\ql Amortization of debt costs\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 64\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 118\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell{
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{\trowd\clvertalb\cellx7621\clvertalb\cellx7728\clvertalb\cellx9046\clvertalb\cellx9190\clvertalb\cellx9334\clvertalb\cellx10652\clvertalb\cellx10796\trrh281
\pard\plain\intbl\li594\ri22\sb22\sa22\cf1\f51\fs20\ql Amortization of premium/discount on investments\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 1,186\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 734\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell{
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{\trowd\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7621\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7728\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9046\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9190\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9334\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10652\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10796\trrh281
\pard\plain\intbl\li594\ri22\sb22\sa22\cf1\f51\fs20\ql Share-based compensation\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 8,882\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 2,777\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell{
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{\trowd\clvertalb\cellx7621\clvertalb\cellx7728\clvertalb\cellx9046\clvertalb\cellx9190\clvertalb\cellx9334\clvertalb\cellx10652\clvertalb\cellx10796\trrh281
\pard\plain\intbl\li594\ri22\sb22\sa22\cf1\f51\fs20\ql Amortization of deferred lease obligation\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 4\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr \u8212?\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell{
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{\trowd\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7621\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7728\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9046\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9190\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9334\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10652\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10796\trrh281
\pard\plain\intbl\li330\ri22\sb22\sa22\cf1\f51\fs20\ql Changes in operating assets and liabilities:\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr \~\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr \~\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell{
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{\trowd\clvertalb\cellx7621\clvertalb\cellx7728\clvertalb\cellx9046\clvertalb\cellx9190\clvertalb\cellx9334\clvertalb\cellx10652\clvertalb\cellx10796\trrh281
\pard\plain\intbl\li594\ri22\sb22\sa22\cf1\f51\fs20\ql Accounts receivable\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr (419\cell\pard\plain\intbl\ri22\sb22\sa22\cf1\f51\fs20\ql )\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr (654\cell\pard\plain\intbl\ri22\sb22\sa22\cf1\f51\fs20\ql )\cell{
{\trowd\clvertalb\cellx7621\clvertalb\cellx7728\clvertalb\cellx9046\clvertalb\cellx9190\clvertalb\cellx9334\clvertalb\cellx10652\clvertalb\cellx10796\trrh281\row}}}
{\trowd\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7621\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7728\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9046\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9190\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9334\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10652\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10796\trrh281
\pard\plain\intbl\li594\ri22\sb22\sa22\cf1\f51\fs20\ql Prepaid expenses and other assets\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr (5,354\cell\pard\plain\intbl\ri22\sb22\sa22\cf1\f51\fs20\ql )\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr (780\cell\pard\plain\intbl\ri22\sb22\sa22\cf1\f51\fs20\ql )\cell{
{\trowd\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7621\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7728\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9046\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9190\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9334\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10652\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10796\trrh281\row}}}
{\trowd\clvertalb\cellx7621\clvertalb\cellx7728\clbrdrb\brdrs\brdrcf1\clvertalb\cellx9046\clbrdrb\brdrs\brdrcf1\clvertalb\cellx9190\clvertalb\cellx9334\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10652\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10796\trrh281
\pard\plain\intbl\li594\ri22\sb22\sa22\cf1\f51\fs20\ql Accounts payable and accrued liabilities\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 7,931\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 6,483\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell{
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\pard\plain\intbl\li858\ri22\sb22\sa22\cf1\f51\fs20\ql Net cash used in operating activities\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr (66,791\cell\pard\plain\intbl\ri22\sb22\sa22\cf1\f51\fs20\ql )\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr (30,204\cell\pard\plain\intbl\ri22\sb22\sa22\cf1\f51\fs20\ql )\cell{
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{\trowd\clvertalb\cellx7621\clvertalb\cellx7728\clvertalb\cellx9191\clvertalb\cellx9335\clvertalb\cellx10798\trrh338
\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell{
{\trowd\clvertalb\cellx7621\clvertalb\cellx7728\clvertalb\cellx9191\clvertalb\cellx9335\clvertalb\cellx10798\trrh338\row}}}
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\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\b\ql Cash flows from investing activities:\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr \~\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr \~\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell{
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{\trowd\clvertalb\cellx7621\clvertalb\cellx7728\clvertalb\cellx9046\clvertalb\cellx9190\clvertalb\cellx9334\clvertalb\cellx10652\clvertalb\cellx10796\trrh281
\pard\plain\intbl\li330\ri22\sb22\sa22\cf1\f51\fs20\ql Purchase of property and equipment\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr (1,574\cell\pard\plain\intbl\ri22\sb22\sa22\cf1\f51\fs20\ql )\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr (703\cell\pard\plain\intbl\ri22\sb22\sa22\cf1\f51\fs20\ql )\cell{
{\trowd\clvertalb\cellx7621\clvertalb\cellx7728\clvertalb\cellx9046\clvertalb\cellx9190\clvertalb\cellx9334\clvertalb\cellx10652\clvertalb\cellx10796\trrh281\row}}}
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\pard\plain\intbl\li330\ri22\sb22\sa22\cf1\f51\fs20\ql Purchase of short-term investments\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr (56,294\cell\pard\plain\intbl\ri22\sb22\sa22\cf1\f51\fs20\ql )\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr (138,058\cell\pard\plain\intbl\ri22\sb22\sa22\cf1\f51\fs20\ql )\cell{
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{\trowd\clvertalb\cellx7621\clvertalb\cellx7728\clvertalb\cellx9046\clvertalb\cellx9190\clvertalb\cellx9334\clvertalb\cellx10652\clvertalb\cellx10796\trrh281
\pard\plain\intbl\li330\ri22\sb22\sa22\cf1\f51\fs20\ql Purchase of long-term investments\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr (212,766\cell\pard\plain\intbl\ri22\sb22\sa22\cf1\f51\fs20\ql )\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr \u8212?\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalb\cellx7621\clvertalb\cellx7728\clvertalb\cellx9046\clvertalb\cellx9190\clvertalb\cellx9334\clvertalb\cellx10652\clvertalb\cellx10796\trrh281\row}}}
{\trowd\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7621\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7728\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9046\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9190\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9334\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10652\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10796\trrh281
\pard\plain\intbl\li330\ri22\sb22\sa22\cf1\f51\fs20\ql Sales of short-term investments\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 1,003\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 2,499\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7621\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7728\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9046\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9190\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9334\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10652\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10796\trrh281\row}}}
{\trowd\clvertalb\cellx7621\clvertalb\cellx7728\clbrdrb\brdrs\brdrcf1\clvertalb\cellx9046\clbrdrb\brdrs\brdrcf1\clvertalb\cellx9190\clvertalb\cellx9334\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10652\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10796\trrh281
\pard\plain\intbl\li330\ri22\sb22\sa22\cf1\f51\fs20\ql Maturities of short-term investments\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 90,822\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 20,690\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalb\cellx7621\clvertalb\cellx7728\clbrdrb\brdrs\brdrcf1\clvertalb\cellx9046\clbrdrb\brdrs\brdrcf1\clvertalb\cellx9190\clvertalb\cellx9334\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10652\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10796\trrh281\row}}}
{\trowd\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7621\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7728\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9046\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9190\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9334\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10652\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10796\trrh281
\pard\plain\intbl\li858\ri22\sb22\sa22\cf1\f51\fs20\ql Net cash used in investing activities\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr (178,809\cell\pard\plain\intbl\ri22\sb22\sa22\cf1\f51\fs20\ql )\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr (115,572\cell\pard\plain\intbl\ri22\sb22\sa22\cf1\f51\fs20\ql )\cell{
{\trowd\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7621\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7728\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9046\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9190\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9334\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10652\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10796\trrh281\row}}}
{\trowd\clvertalb\cellx7621\clvertalb\cellx7728\clvertalb\cellx9191\clvertalb\cellx9335\clvertalb\cellx10798\trrh338
\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell{
{\trowd\clvertalb\cellx7621\clvertalb\cellx7728\clvertalb\cellx9191\clvertalb\cellx9335\clvertalb\cellx10798\trrh338\row}}}
{\trowd\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7621\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7728\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9046\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9190\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9334\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10652\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10796\trrh281
\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\b\ql Cash flows from financing activities:\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr \~\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr \~\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7621\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7728\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9046\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9190\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9334\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10652\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10796\trrh281\row}}}
{\trowd\clvertalb\cellx7621\clvertalb\cellx7728\clvertalb\cellx9046\clvertalb\cellx9190\clvertalb\cellx9334\clvertalb\cellx10652\clvertalb\cellx10796\trrh281
\pard\plain\intbl\li330\ri22\sb22\sa22\cf1\f51\fs20\ql Proceeds from exercise of stock options\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 1,967\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 2,148\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalb\cellx7621\clvertalb\cellx7728\clvertalb\cellx9046\clvertalb\cellx9190\clvertalb\cellx9334\clvertalb\cellx10652\clvertalb\cellx10796\trrh281\row}}}
{\trowd\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7621\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7728\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9046\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9190\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9334\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10652\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10796\trrh281
\pard\plain\intbl\li330\ri22\sb22\sa22\cf1\f51\fs20\ql Proceeds from employee stock purchase plan stock purchases\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 1,054\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 426\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7621\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7728\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9046\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9190\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9334\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10652\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10796\trrh281\row}}}
{\trowd\clvertalb\cellx7621\clvertalb\cellx7728\clvertalb\cellx9046\clvertalb\cellx9190\clvertalb\cellx9334\clvertalb\cellx10652\clvertalb\cellx10796\trrh281
\pard\plain\intbl\li330\ri22\sb22\sa22\cf1\f51\fs20\ql Proceeds from exercise of warrants\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 1,000\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 6\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalb\cellx7621\clvertalb\cellx7728\clvertalb\cellx9046\clvertalb\cellx9190\clvertalb\cellx9334\clvertalb\cellx10652\clvertalb\cellx10796\trrh281\row}}}
{\trowd\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7621\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7728\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9046\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9190\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9334\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10652\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10796\trrh281
\pard\plain\intbl\li330\ri22\sb22\sa22\cf1\f51\fs20\ql Proceeds from public offering, net of offering costs\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 161,880\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 111,845\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7621\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7728\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9046\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9190\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9334\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10652\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10796\trrh281\row}}}
{\trowd\clvertalb\cellx7621\clvertalb\cellx7728\clvertalb\cellx9046\clvertalb\cellx9190\clvertalb\cellx9334\clvertalb\cellx10652\clvertalb\cellx10796\trrh281
\pard\plain\intbl\li330\ri22\sb22\sa22\cf1\f51\fs20\ql Repayment of debt\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr (3,975\cell\pard\plain\intbl\ri22\sb22\sa22\cf1\f51\fs20\ql )\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr (4,275\cell\pard\plain\intbl\ri22\sb22\sa22\cf1\f51\fs20\ql )\cell{
{\trowd\clvertalb\cellx7621\clvertalb\cellx7728\clvertalb\cellx9046\clvertalb\cellx9190\clvertalb\cellx9334\clvertalb\cellx10652\clvertalb\cellx10796\trrh281\row}}}
{\trowd\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7621\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7728\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9046\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9190\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9334\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10652\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10796\trrh281
\pard\plain\intbl\li330\ri22\sb22\sa22\cf1\f51\fs20\ql Payments for deferred financing costs\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr (68\cell\pard\plain\intbl\ri22\sb22\sa22\cf1\f51\fs20\ql )\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr \u8212?\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7621\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7728\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9046\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9190\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9334\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10652\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10796\trrh281\row}}}
{\trowd\clvertalb\cellx7621\clvertalb\cellx7728\clbrdrb\brdrs\brdrcf1\clvertalb\cellx9046\clbrdrb\brdrs\brdrcf1\clvertalb\cellx9190\clvertalb\cellx9334\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10652\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10796\trrh281
\pard\plain\intbl\li858\ri22\sb22\sa22\cf1\f51\fs20\ql Net cash provided by financing activities\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 161,858\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 110,150\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalb\cellx7621\clvertalb\cellx7728\clbrdrb\brdrs\brdrcf1\clvertalb\cellx9046\clbrdrb\brdrs\brdrcf1\clvertalb\cellx9190\clvertalb\cellx9334\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10652\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10796\trrh281\row}}}
{\trowd\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7621\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7728\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9046\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9190\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9334\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10652\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10796\trrh281
\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql Net decrease in cash and cash equivalents\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr (83,742\cell\pard\plain\intbl\ri22\sb22\sa22\cf1\f51\fs20\ql )\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr (35,626\cell\pard\plain\intbl\ri22\sb22\sa22\cf1\f51\fs20\ql )\cell{
{\trowd\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7621\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7728\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9046\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9190\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9334\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10652\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10796\trrh281\row}}}
{\trowd\clvertalb\cellx7621\clvertalb\cellx7728\clvertalb\cellx9191\clvertalb\cellx9335\clvertalb\cellx10798\trrh281
\pard\plain\intbl\li330\ri22\sb22\sa22\cf1\f51\fs20\ql Cash and cash equivalents:\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell{
{\trowd\clvertalb\cellx7621\clvertalb\cellx7728\clvertalb\cellx9191\clvertalb\cellx9335\clvertalb\cellx10798\trrh281\row}}}
{\trowd\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7621\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7728\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9046\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9190\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9334\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10652\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10796\trrh281
\pard\plain\intbl\li594\ri22\sb22\sa22\cf1\f51\fs20\ql Beginning of period\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 128,462\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 109,976\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell{
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\pard\plain\intbl\li594\ri22\sb22\sa22\cf1\f51\fs20\ql End of period\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\ql $\cell\pard\plain\intbl\sb22\sa22\cf1\f51\fs20\qr 44,720\cell
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\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\b\ql Supplemental disclosure cash flow information:\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr \~\cell
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\pard\plain\intbl\li330\ri22\sb22\sa22\cf1\f51\fs20\ql Cash paid for interest\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\ql $\cell\pard\plain\intbl\sb22\sa22\cf1\f51\fs20\qr 156\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\ql $\cell\pard\plain\intbl\sb22\sa22\cf1\f51\fs20\qr 552\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7621\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7728\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7872\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9046\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9190\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9334\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9478\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10652\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10796\trrh281\row}}}\pard\plain\fi792\cf1\f51\fs20\qc \~\par\pard\plain\cf1\f51\fs20\qc The accompanying notes are an integral part of the consolidated financial statements.
\par\pard\plain\fs16\par\pard\plain\fi792\cf1\f51\fs20\qc \~\par\pard\plain\fi792\cf1\f51\fs20\qc \~
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qc 5
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\par\pard\plain\fs16
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\b\qc CHIMERIX, INC.\par\pard\plain\cf1\f51\fs20\b\qc NOTES TO CONSOLIDATED FINANCIAL STATEMENTS\par\pard\plain\cf1\f51\fs20\b\qc (unaudited)\par\pard\plain\fi792\cf1\f51\fs20\qc \~{\*\bkmkstart sF6632B2EA6E0948CBE696612942B370}{\*\bkmkend sF6632B2EA6E0948CBE696612942B370}\par\pard\plain\cf1\f51\fs20\b\ql Note 1. The Business and Summary of Significant Accounting Policies\par\pard\plain\fi792\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\i\ql Description of Business
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj Chimerix, Inc. (the Company) is a biopharmaceutical company dedicated to discovering, developing and commercializing novel,\plain\cf1\f51\fs20\qj oral antivirals to address unmet medical needs. The Company was founded in 2000 based on the promise of its proprietary lipid\plain\cf1\f51\fs20\qj conjugate technology to unlock the potential of some of the most potent broad-spectrum antivirals by enhancing their antiviral\plain\cf1\f51\fs20\qj activity and safety profiles in convenient, orally administered dosing regimens. Based on the Company\u8217?s proprietary lipid\plain\cf1\f51\fs20\qj conjugate technology, its lead compound, brincidofovir, is in Phase 3 clinical development. In addition, the Company has an\plain\cf1\f51\fs20\qj active discovery program focusing on viral targets for which limited or no therapies are currently available.
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\b\i\ql Basis of Presentation
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj The accompanying unaudited consolidated financial statements include the accounts of the Company and its wholly owned\plain\cf1\f51\fs20\qj subsidiary and have been prepared in accordance with U.S. generally accepted accounting principles (GAAP), for interim\plain\cf1\f51\fs20\qj financial information, the instructions to Form 10-Q and Article 10 of Regulation S-X. Accordingly, they do not include all of\plain\cf1\f51\fs20\qj the information and footnotes required by GAAP for complete financial statements and should be read in conjunction with the\plain\cf1\f51\fs20\qj Company\u8217?s audited financial statements and notes thereto included in its Annual Report on Form 10-K for the year ended\plain\cf1\f51\fs20\qj December\~31, 2014.\~ In the opinion of the Company\u8217?s management, all adjustments, consisting of normal recurring\plain\cf1\f51\fs20\qj adjustments, necessary for a fair presentation of its financial position, operating results and cash flows for the periods presented\plain\cf1\f51\fs20\qj have been included.\~ Operating results for the three and nine months ended September\~30, 2015 are not necessarily indicative of\plain\cf1\f51\fs20\qj the results that may be expected for the full year, for any other interim period or for any future year.\~\par\pard\plain\fi792\cf1\f51\fs20\qj \~\par\pard\plain\cf1\f51\fs20\b\i\ql Fair Value of Financial Instruments
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj The carrying amounts of certain financial instruments, including accounts receivable, accounts payable and accrued expenses\plain\cf1\f51\fs20\qj approximate their fair values due to the short-term nature of such instruments. The carrying amount of borrowings under loans\plain\cf1\f51\fs20\qj payable approximates its fair value based on the determination that the stated rate on such loans payable is consistent with\plain\cf1\f51\fs20\qj current interest rates for similar borrowing arrangements available to the Company.\par\pard\plain\fi792\cf1\f51\fs20\qj \~\par\pard\plain\cf1\f51\fs20\qj For assets and liabilities recorded at fair value, it is the Company\u8217?s policy to maximize the use of observable inputs and\plain\cf1\f51\fs20\qj minimize the use of unobservable inputs when developing fair value measurements, in accordance with the fair value hierarchy.\plain\cf1\f51\fs20\qj Fair value measurements for assets and liabilities where there exists limited or no observable market data are based primarily\plain\cf1\f51\fs20\qj upon estimates and are often calculated based on the economic and competitive environment, the characteristics of the asset or\plain\cf1\f51\fs20\qj liability and other factors. Therefore, fair value measurements cannot be determined with precision and may not be realized in an\plain\cf1\f51\fs20\qj actual sale or immediate settlement of the asset or liability. Additionally, there may be inherent weaknesses in any calculation\plain\cf1\f51\fs20\qj technique and changes in the underlying assumptions used, including discount rates and estimates of future cash flows, could\plain\cf1\f51\fs20\qj significantly affect the calculated current or future fair values. The Company utilizes fair value measurements to record fair value\plain\cf1\f51\fs20\qj adjustments to certain assets and liabilities and to determine fair value disclosures.\par\pard\plain\fi792\cf1\f51\fs20\qj \~\par\pard\plain\cf1\f51\fs20\qj The Company groups assets and liabilities at fair value in three levels, based on the markets in which the assets and liabilities are\plain\cf1\f51\fs20\qj traded and the reliability of the assumptions used to determine fair value. An adjustment to the pricing method used within either\plain\cf1\f51\fs20\qj Level 1 or Level 2 inputs could generate a fair value measurement that effectively falls in a lower level in the hierarchy. These\plain\cf1\f51\fs20\qj levels are:\par\pard\plain\fi792\cf1\f51\fs20\qj \~
\par\pard\plain
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\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
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{\trowd\cellx664\cellx10799\trrh562
\pard\plain\intbl\li132\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\i\ql Level 1\plain\intbl\cf1\f51\fs20\ql \u8212? Valuations based on unadjusted quoted prices in active markets for identical assets or liabilities that the\plain\intbl\cf1\f51\fs20\ql Company has the ability to access.\cell{
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\pard\plain
{\trowd\clvertalc\cellx664\clvertalc\cellx10799\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
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{\trowd\cellx664\cellx10799\trrh810
\pard\plain\intbl\li132\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\i\ql Level 2\plain\intbl\cf1\f51\fs20\ql \u8212? Valuations based on quoted prices for similar assets or liabilities in active markets, quoted prices for\plain\intbl\cf1\f51\fs20\ql identical or similar assets or liabilities in markets that are not active, and models for which all significant inputs are\plain\intbl\cf1\f51\fs20\ql observable, either directly or indirectly.\cell{
{\trowd\cellx664\cellx10799\trrh810\row}}}
\pard\plain
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\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx664\clvertalc\cellx10799\trrh-66\row}}}
{\trowd\cellx664\cellx10799\trrh315
\pard\plain\intbl\li132\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\i\ql Level 3\plain\intbl\cf1\f51\fs20\ql \u8212? Valuations based on inputs that are unobservable and significant to the overall fair value measurement.\cell{
{\trowd\cellx664\cellx10799\trrh315\row}}}
\par\pard\plain\fs16\pard\plain\cf1\f51\fs20\qj The determination of where an asset or liability falls in the hierarchy requires significant judgment. The Company evaluates\plain\cf1\f51\fs20\qj hierarchy disclosures and, based on various factors, it is possible that an asset or liability may be classified differently from\plain\cf1\f51\fs20\qj period to period. However, the Company expects that changes in classification between levels will be rare.
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qc 6
\par\pard\plain\fs16\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par
\page
\par\pard\plain\fs16
\par\pard\plain\fs16\par\pard\plain\fi792\cf1\f51\fs20\qj \~\par\pard\plain\cf1\f51\fs20\qj At September\~30, 2015 and December\~31, 2014, the Company had cash equivalents, consisting of money market accounts, and\plain\cf1\f51\fs20\qj short-term and long-term investments consisting of U.S. Treasury securities, whose value is based on using quoted market\plain\cf1\f51\fs20\qj prices. Accordingly, these securities are classified as Level 1.\par\pard\plain\cf1\f51\fs20\qj \~\par\pard\plain\cf1\f51\fs20\qj At September\~30, 2015 and December\~31, 2014, the Company had cash equivalents, short-term investments and long-term\plain\cf1\f51\fs20\qj investments comprised of corporate bonds, commercial paper and brokered certificates of deposit for which quoted prices are not\plain\cf1\f51\fs20\qj available that are valued using independent pricing models or other model-based valuation techniques such as the present value\plain\cf1\f51\fs20\qj of future cash flows, adjusted for the security\u8217?s credit rating, prepayment assumptions and other factors such as credit loss\plain\cf1\f51\fs20\qj assumptions. Accordingly, these securities are classified as Level 2.\par\pard\plain\fi792\cf1\f51\fs20\qj \~\par\pard\plain\cf1\f51\fs20\qj The Company\u8217?s preferred stock investment in ContraVir Pharmaceuticals (NASDAQ: CTRV) (ContraVir) is categorized as\plain\cf1\f51\fs20\qj Level 3 as there are significant unobservable inputs. The valuation of the investment at September\~30, 2015 and December\~31,\plain\cf1\f51\fs20\qj 2014 was calculated on an as if converted to common share basis with a discount for lack of marketability applied due to the 18\plain\cf1\f51\fs20\qj month restriction from the date of the investment on selling the converted common shares. An option pricing model was used to\plain\cf1\f51\fs20\qj determine the discount for lack of marketability of 18% and 25% at September\~30, 2015 and December\~31, 2014, respectively.\plain\cf1\f51\fs20\qj The key unobservable inputs used in the option pricing model at September\~30, 2015 were (i) exercise price - $2.09, (ii)\plain\cf1\f51\fs20\qj dividend yield - 0%, (iii) expected holding period\~-\~0.7 years, (iv) risk-free rate - 0.21%, and (v) volatility\~-\~65%. The key\plain\cf1\f51\fs20\qj unobservable inputs used in the option pricing model at December\~31, 2014 were (i) exercise price - $2.22, (ii) dividend yield -\plain\cf1\f51\fs20\qj 0%, (iii) expected holding period\~-\~1.5 years, (iv) risk-free rate - 0.44%, and (v) volatility\~-\~65%. The change in valuation of\plain\cf1\f51\fs20\qj the preferred stock for the three and nine months ended September\~30, 2015 was recorded as an unrealized (loss) gain on\plain\cf1\f51\fs20\qj investments, net in the Consolidated Statements of Operations and Comprehensive Loss.
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj There was no material re-measurement to fair value of financial assets and liabilities that are not measured at fair value on a\plain\cf1\f51\fs20\qj recurring basis.\par\pard\plain\fi792\cf1\f51\fs20\qj \~
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qc 7
\par\pard\plain\fs16\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par
\page
\par\pard\plain\fs16
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj Below is a table that presents information about certain assets and liabilities measured at fair value on a recurring basis (in\plain\cf1\f51\fs20\qj thousands):\par\pard\plain\fi792\cf1\f51\fs20\qj \~
\par\pard\plain
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\pard\plain\intbl\f0\fs16\ql \~\cell{
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\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
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\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\b\qc Fair\~Value\~Measurements\cell{
{\trowd\clvertalb\cellx2506\clvertalb\cellx10799\trrh281\row}}}
{\trowd\clvertalb\cellx2506\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10799\trrh281
\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\b\qc September\~30, 2015\cell{
{\trowd\clvertalb\cellx2506\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10799\trrh281\row}}}
{\trowd\clvertalb\cellx2506\clbrdrb\brdrs\brdrcf1\clvertalb\cellx3930\clvertalb\cellx4079\clbrdrb\brdrs\brdrcf1\clvertalb\cellx6321\clbrdrb\brdrs\brdrcf1\clvertalb\cellx6470\clbrdrb\brdrs\brdrcf1\clvertalb\cellx8675\clbrdrb\brdrs\brdrcf1\clvertalb\cellx8824\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10796\trrh925
\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs18\b\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs18\b\qc Total\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\cf1\f51\fs18\b\qc Quoted\~Prices\~in
\par\pard\plain\intbl\fs16\pard\plain\intbl\li22\ri22\cf1\f51\fs18\b\qc Active\~Markets
\par\pard\plain\intbl\fs16\pard\plain\intbl\li22\ri22\cf1\f51\fs18\b\qc for\~Identical\~Assets
\par\pard\plain\intbl\fs16\pard\plain\intbl\li22\ri22\sa22\cf1\f51\fs18\b\qc (Level\~1)\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\cf1\f51\fs18\b\qc Significant\~Other
\par\pard\plain\intbl\fs16\pard\plain\intbl\li22\ri22\cf1\f51\fs18\b\qc Observable\~Inputs
\par\pard\plain\intbl\fs16\pard\plain\intbl\li22\ri22\sa22\cf1\f51\fs18\b\qc (Level\~2)\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\cf1\f51\fs18\b\qc Significant
\par\pard\plain\intbl\fs16\pard\plain\intbl\li22\ri22\cf1\f51\fs18\b\qc Unobservable\~Inputs
\par\pard\plain\intbl\fs16\pard\plain\intbl\li22\ri22\sa22\cf1\f51\fs18\b\qc (Level\~3)\cell{
{\trowd\clvertalb\cellx2506\clbrdrb\brdrs\brdrcf1\clvertalb\cellx3930\clvertalb\cellx4079\clbrdrb\brdrs\brdrcf1\clvertalb\cellx6321\clbrdrb\brdrs\brdrcf1\clvertalb\cellx6470\clbrdrb\brdrs\brdrcf1\clvertalb\cellx8675\clbrdrb\brdrs\brdrcf1\clvertalb\cellx8824\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10796\trrh925\row}}}
{\trowd\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx2506\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx3930\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10799\trrh281
\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql Cash equivalents\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell{
{\trowd\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx2506\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx3930\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10799\trrh281\row}}}
{\trowd\clvertalb\cellx2506\clvertalb\cellx2655\clvertalb\cellx3780\clvertalb\cellx3929\clvertalb\cellx4078\clvertalb\cellx4577\clvertalb\cellx5819\clvertalb\cellx6318\clvertalb\cellx6467\clvertalb\cellx6948\clvertalb\cellx8190\clvertalb\cellx8671\clvertalb\cellx8820\clvertalb\cellx9361\clvertalb\cellx10250\clvertalb\cellx10791\trrh281
\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\~\~\~\~Money market funds\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\ql $\cell\pard\plain\intbl\sb22\sa22\cf1\f51\fs20\qr 17,847\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\ql $\cell\pard\plain\intbl\sb22\sa22\cf1\f51\fs20\qr 17,847\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\ql $\cell\pard\plain\intbl\sb22\sa22\cf1\f51\fs20\qr \u8212?\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\ql $\cell\pard\plain\intbl\sb22\sa22\cf1\f51\fs20\qr \u8212?\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalb\cellx2506\clvertalb\cellx2655\clvertalb\cellx3780\clvertalb\cellx3929\clvertalb\cellx4078\clvertalb\cellx4577\clvertalb\cellx5819\clvertalb\cellx6318\clvertalb\cellx6467\clvertalb\cellx6948\clvertalb\cellx8190\clvertalb\cellx8671\clvertalb\cellx8820\clvertalb\cellx9361\clvertalb\cellx10250\clvertalb\cellx10791\trrh281\row}}}
{\trowd\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx2506\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx3781\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx3930\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4079\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5821\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6320\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6469\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8193\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8674\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8823\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10254\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10795\trrh281
\pard\plain\intbl\li330\ri22\sb22\sa22\cf1\f51\fs20\ql Commercial paper\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 24,996\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr \u8212?\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 24,996\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr \u8212?\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx2506\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx3781\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx3930\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4079\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5821\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6320\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6469\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8193\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8674\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8823\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10254\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10795\trrh281\row}}}
{\trowd\clvertalb\cellx2506\clvertalb\cellx3781\clvertalb\cellx3930\clvertalb\cellx4079\clvertalb\cellx5821\clvertalb\cellx6320\clvertalb\cellx6469\clvertalb\cellx8193\clvertalb\cellx8674\clvertalb\cellx8823\clvertalb\cellx10254\clvertalb\cellx10795\trrh281
\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\~\~\~\~\~\~\~\~\~Total cash equivalents\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 42,843\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 17,847\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 24,996\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr \u8212?\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalb\cellx2506\clvertalb\cellx3781\clvertalb\cellx3930\clvertalb\cellx4079\clvertalb\cellx5821\clvertalb\cellx6320\clvertalb\cellx6469\clvertalb\cellx8193\clvertalb\cellx8674\clvertalb\cellx8823\clvertalb\cellx10254\clvertalb\cellx10795\trrh281\row}}}
{\trowd\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx2506\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx3930\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4079\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6321\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6470\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8675\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8824\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10796\trrh281
\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql Short-term investments\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell{
{\trowd\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx2506\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx3930\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4079\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6321\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6470\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8675\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8824\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10796\trrh281\row}}}
{\trowd\clvertalb\cellx2506\clvertalb\cellx3781\clvertalb\cellx3930\clvertalb\cellx4079\clvertalb\cellx5821\clvertalb\cellx6320\clvertalb\cellx6469\clvertalb\cellx8193\clvertalb\cellx8674\clvertalb\cellx8823\clvertalb\cellx10254\clvertalb\cellx10795\trrh281
\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\~\~\~\~Certificates of deposit\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 22,093\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr \u8212?\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 22,093\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr \u8212?\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalb\cellx2506\clvertalb\cellx3781\clvertalb\cellx3930\clvertalb\cellx4079\clvertalb\cellx5821\clvertalb\cellx6320\clvertalb\cellx6469\clvertalb\cellx8193\clvertalb\cellx8674\clvertalb\cellx8823\clvertalb\cellx10254\clvertalb\cellx10795\trrh281\row}}}
{\trowd\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx2506\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx3781\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx3930\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4079\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5821\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6320\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6469\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8193\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8674\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8823\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10254\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10795\trrh281
\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\~\~\~\~Corporate bonds\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 3,001\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr \u8212?\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 3,001\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr \u8212?\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx2506\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx3781\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx3930\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4079\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5821\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6320\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6469\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8193\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8674\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8823\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10254\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10795\trrh281\row}}}
{\trowd\clvertalb\cellx2506\clvertalb\cellx3781\clvertalb\cellx3930\clvertalb\cellx4079\clvertalb\cellx5821\clvertalb\cellx6320\clvertalb\cellx6469\clvertalb\cellx8193\clvertalb\cellx8674\clvertalb\cellx8823\clvertalb\cellx10254\clvertalb\cellx10795\trrh281
\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\~\~\~\~U.S. Treasury securities\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 149,144\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 149,144\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr \u8212?\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr \u8212?\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalb\cellx2506\clvertalb\cellx3781\clvertalb\cellx3930\clvertalb\cellx4079\clvertalb\cellx5821\clvertalb\cellx6320\clvertalb\cellx6469\clvertalb\cellx8193\clvertalb\cellx8674\clvertalb\cellx8823\clvertalb\cellx10254\clvertalb\cellx10795\trrh281\row}}}
{\trowd\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx2506\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx3781\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx3930\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4079\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5821\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6320\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6469\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8193\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8674\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8823\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10254\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10795\trrh529
\pard\plain\intbl\li22\ri22\sb22\cf1\f51\fs20\ql \~\~\~\~\~Preferred stock of U.S.\plain\intbl\li22\ri22\sa22\cf1\f51\fs20\ql corporation\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 1,842\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr \u8212?\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 1,842\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx2506\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx3781\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx3930\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4079\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5821\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6320\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6469\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8193\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8674\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8823\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10254\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10795\trrh529\row}}}
{\trowd\clvertalb\cellx2506\clbrdrt\brdrs\brdrcf1\clvertalb\cellx3781\clbrdrt\brdrs\brdrcf1\clvertalb\cellx3930\clvertalb\cellx4079\clbrdrt\brdrs\brdrcf1\clvertalb\cellx5821\clbrdrt\brdrs\brdrcf1\clvertalb\cellx6320\clvertalb\cellx6469\clbrdrt\brdrs\brdrcf1\clvertalb\cellx8193\clbrdrt\brdrs\brdrcf1\clvertalb\cellx8674\clvertalb\cellx8823\clbrdrt\brdrs\brdrcf1\clvertalb\cellx10254\clbrdrt\brdrs\brdrcf1\clvertalb\cellx10795\trrh529
\pard\plain\intbl\li22\ri22\sb22\cf1\f51\fs20\ql \~\~\~\~\~\~\~\~\~\~Total short-term\plain\intbl\li22\ri22\sa22\cf1\f51\fs20\ql investments\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 176,080\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 149,144\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 25,094\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 1,842\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalb\cellx2506\clbrdrt\brdrs\brdrcf1\clvertalb\cellx3781\clbrdrt\brdrs\brdrcf1\clvertalb\cellx3930\clvertalb\cellx4079\clbrdrt\brdrs\brdrcf1\clvertalb\cellx5821\clbrdrt\brdrs\brdrcf1\clvertalb\cellx6320\clvertalb\cellx6469\clbrdrt\brdrs\brdrcf1\clvertalb\cellx8193\clbrdrt\brdrs\brdrcf1\clvertalb\cellx8674\clvertalb\cellx8823\clbrdrt\brdrs\brdrcf1\clvertalb\cellx10254\clbrdrt\brdrs\brdrcf1\clvertalb\cellx10795\trrh529\row}}}
{\trowd\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx2506\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx3930\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4079\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6321\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6470\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8675\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8824\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10796\trrh281
\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql Long-term investments\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell{
{\trowd\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx2506\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx3930\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4079\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6321\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6470\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8675\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8824\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10796\trrh281\row}}}
{\trowd\clvertalb\cellx2506\clvertalb\cellx3781\clvertalb\cellx3930\clvertalb\cellx4079\clvertalb\cellx5821\clvertalb\cellx6320\clvertalb\cellx6469\clvertalb\cellx8193\clvertalb\cellx8674\clvertalb\cellx8823\clvertalb\cellx10254\clvertalb\cellx10795\trrh281
\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\~\~\~\~Certificates of deposit\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 16,816\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr \u8212?\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 16,816\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr \u8212?\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalb\cellx2506\clvertalb\cellx3781\clvertalb\cellx3930\clvertalb\cellx4079\clvertalb\cellx5821\clvertalb\cellx6320\clvertalb\cellx6469\clvertalb\cellx8193\clvertalb\cellx8674\clvertalb\cellx8823\clvertalb\cellx10254\clvertalb\cellx10795\trrh281\row}}}
{\trowd\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx2506\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx3781\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx3930\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4079\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5821\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6320\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6469\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8193\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8674\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8823\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10254\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10795\trrh281
\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\~\~\~\~U.S. Treasury securities\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 142,670\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 142,670\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr \u8212?\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr \u8212?\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx2506\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx3781\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx3930\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4079\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5821\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6320\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6469\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8193\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8674\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8823\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10254\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10795\trrh281\row}}}
{\trowd\clvertalb\cellx2506\clbrdrb\brdrs\brdrcf1\clvertalb\cellx3781\clbrdrb\brdrs\brdrcf1\clvertalb\cellx3930\clvertalb\cellx4079\clbrdrb\brdrs\brdrcf1\clvertalb\cellx5821\clbrdrb\brdrs\brdrcf1\clvertalb\cellx6320\clvertalb\cellx6469\clbrdrb\brdrs\brdrcf1\clvertalb\cellx8193\clbrdrb\brdrs\brdrcf1\clvertalb\cellx8674\clbrdrb\brdrs\brdrcf1\clvertalb\cellx8823\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10254\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10795\trrh529
\pard\plain\intbl\li22\ri22\sb22\cf1\f51\fs20\ql \~\~\~\~\~\~\~\~\~\~Total long-term\plain\intbl\li22\ri22\sa22\cf1\f51\fs20\ql investments\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 159,486\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 142,670\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 16,816\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr \u8212?\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalb\cellx2506\clbrdrb\brdrs\brdrcf1\clvertalb\cellx3781\clbrdrb\brdrs\brdrcf1\clvertalb\cellx3930\clvertalb\cellx4079\clbrdrb\brdrs\brdrcf1\clvertalb\cellx5821\clbrdrb\brdrs\brdrcf1\clvertalb\cellx6320\clvertalb\cellx6469\clbrdrb\brdrs\brdrcf1\clvertalb\cellx8193\clbrdrb\brdrs\brdrcf1\clvertalb\cellx8674\clbrdrb\brdrs\brdrcf1\clvertalb\cellx8823\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10254\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10795\trrh529\row}}}
{\trowd\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx2506\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx2655\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx3780\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx3929\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4078\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4577\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5819\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6318\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6467\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6948\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8190\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8671\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8820\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9361\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10250\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10791\trrh281
\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\~\~\~\~\~\~\~\~\~\~\~\~\~\~Total assets\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\ql $\cell\pard\plain\intbl\sb22\sa22\cf1\f51\fs20\qr 378,409\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\ql $\cell\pard\plain\intbl\sb22\sa22\cf1\f51\fs20\qr 309,661\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\ql $\cell\pard\plain\intbl\sb22\sa22\cf1\f51\fs20\qr 66,906\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\ql $\cell\pard\plain\intbl\sb22\sa22\cf1\f51\fs20\qr 1,842\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx2506\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx2655\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx3780\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx3929\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4078\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4577\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5819\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6318\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6467\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6948\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8190\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8671\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8820\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9361\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10250\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10791\trrh281\row}}}
{\trowd\clvertalb\cellx2506\clvertalb\cellx3930\clvertalb\cellx4079\clvertalb\cellx6321\clvertalb\cellx6470\clvertalb\cellx8675\clvertalb\cellx8824\clvertalb\cellx10796\trrh371
\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell{
{\trowd\clvertalb\cellx2506\clvertalb\cellx3930\clvertalb\cellx4079\clvertalb\cellx6321\clvertalb\cellx6470\clvertalb\cellx8675\clvertalb\cellx8824\clvertalb\cellx10796\trrh371\row}}}
{\trowd\clvertalb\cellx2506\clvertalb\cellx10799\trrh281
\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\b\qc Fair\~Value\~Measurements\cell{
{\trowd\clvertalb\cellx2506\clvertalb\cellx10799\trrh281\row}}}
{\trowd\clvertalb\cellx2506\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10799\trrh281
\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\b\qc December\~31, 2014\cell{
{\trowd\clvertalb\cellx2506\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10799\trrh281\row}}}
{\trowd\clvertalb\cellx2506\clbrdrb\brdrs\brdrcf1\clvertalb\cellx3930\clvertalb\cellx4079\clbrdrb\brdrs\brdrcf1\clvertalb\cellx6321\clvertalb\cellx6470\clbrdrb\brdrs\brdrcf1\clvertalb\cellx8675\clvertalb\cellx8824\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10796\trrh925
\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\b\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs18\b\qc Total\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\cf1\f51\fs18\b\qc Quoted\~Prices\~in
\par\pard\plain\intbl\fs16\pard\plain\intbl\li22\ri22\cf1\f51\fs18\b\qc Active\~Markets
\par\pard\plain\intbl\fs16\pard\plain\intbl\li22\ri22\cf1\f51\fs18\b\qc for\~Identical\~Assets
\par\pard\plain\intbl\fs16\pard\plain\intbl\li22\ri22\sa22\cf1\f51\fs18\b\qc (Level\~1)\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\cf1\f51\fs18\b\qc Significant\~Other
\par\pard\plain\intbl\fs16\pard\plain\intbl\li22\ri22\cf1\f51\fs18\b\qc Observable\~Inputs
\par\pard\plain\intbl\fs16\pard\plain\intbl\li22\ri22\sa22\cf1\f51\fs18\b\qc (Level\~2)\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\cf1\f51\fs18\b\qc Significant
\par\pard\plain\intbl\fs16\pard\plain\intbl\li22\ri22\cf1\f51\fs18\b\qc Unobservable\~Inputs
\par\pard\plain\intbl\fs16\pard\plain\intbl\li22\ri22\sa22\cf1\f51\fs18\b\qc (Level\~3)\cell{
{\trowd\clvertalb\cellx2506\clbrdrb\brdrs\brdrcf1\clvertalb\cellx3930\clvertalb\cellx4079\clbrdrb\brdrs\brdrcf1\clvertalb\cellx6321\clvertalb\cellx6470\clbrdrb\brdrs\brdrcf1\clvertalb\cellx8675\clvertalb\cellx8824\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10796\trrh925\row}}}
{\trowd\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx2506\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx3930\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4079\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6321\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6470\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8675\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8824\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10796\trrh281
\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql Cash equivalents\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell{
{\trowd\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx2506\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx3930\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4079\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6321\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6470\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8675\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8824\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10796\trrh281\row}}}
{\trowd\clvertalb\cellx2506\clvertalb\cellx2655\clvertalb\cellx3780\clvertalb\cellx3929\clvertalb\cellx4078\clvertalb\cellx4577\clvertalb\cellx5819\clvertalb\cellx6318\clvertalb\cellx6467\clvertalb\cellx6948\clvertalb\cellx8190\clvertalb\cellx8671\clvertalb\cellx8820\clvertalb\cellx9361\clvertalb\cellx10250\clvertalb\cellx10791\trrh281
\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\~\~\~\~Money market funds\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\ql $\cell\pard\plain\intbl\sb22\sa22\cf1\f51\fs20\qr 125,606\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\ql $\cell\pard\plain\intbl\sb22\sa22\cf1\f51\fs20\qr 125,606\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\ql $\cell\pard\plain\intbl\sb22\sa22\cf1\f51\fs20\qr \u8212?\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\ql $\cell\pard\plain\intbl\sb22\sa22\cf1\f51\fs20\qr \u8212?\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalb\cellx2506\clvertalb\cellx2655\clvertalb\cellx3780\clvertalb\cellx3929\clvertalb\cellx4078\clvertalb\cellx4577\clvertalb\cellx5819\clvertalb\cellx6318\clvertalb\cellx6467\clvertalb\cellx6948\clvertalb\cellx8190\clvertalb\cellx8671\clvertalb\cellx8820\clvertalb\cellx9361\clvertalb\cellx10250\clvertalb\cellx10791\trrh281\row}}}
{\trowd\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx2506\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx3781\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx3930\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4079\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5821\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6320\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6469\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8193\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8674\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8823\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10254\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10795\trrh281
\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\~\~\~\~Certificates of deposit\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 480\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr \u8212?\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 480\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr \u8212?\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx2506\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx3781\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx3930\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4079\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5821\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6320\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6469\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8193\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8674\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8823\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10254\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10795\trrh281\row}}}
{\trowd\clvertalb\cellx2506\clvertalb\cellx3781\clvertalb\cellx3930\clvertalb\cellx4079\clvertalb\cellx5821\clvertalb\cellx6320\clvertalb\cellx6469\clvertalb\cellx8193\clvertalb\cellx8674\clvertalb\cellx8823\clvertalb\cellx10254\clvertalb\cellx10795\trrh281
\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\~\~\~\~\~\~\~\~\~Total cash equivalents\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 126,086\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 125,606\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 480\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr \u8212?\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalb\cellx2506\clvertalb\cellx3781\clvertalb\cellx3930\clvertalb\cellx4079\clvertalb\cellx5821\clvertalb\cellx6320\clvertalb\cellx6469\clvertalb\cellx8193\clvertalb\cellx8674\clvertalb\cellx8823\clvertalb\cellx10254\clvertalb\cellx10795\trrh281\row}}}
{\trowd\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx2506\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx3930\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4079\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6321\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6470\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8675\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8824\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10796\trrh281
\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql Short-term investments\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell{
{\trowd\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx2506\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx3930\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4079\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6321\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6470\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8675\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8824\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10796\trrh281\row}}}
{\trowd\clvertalb\cellx2506\clvertalb\cellx3781\clvertalb\cellx3930\clvertalb\cellx4079\clvertalb\cellx5821\clvertalb\cellx6320\clvertalb\cellx6469\clvertalb\cellx8193\clvertalb\cellx8674\clvertalb\cellx8823\clvertalb\cellx10254\clvertalb\cellx10795\trrh281
\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\~\~\~\~Certificates of deposit\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 16,981\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr \u8212?\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 16,981\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr \u8212?\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalb\cellx2506\clvertalb\cellx3781\clvertalb\cellx3930\clvertalb\cellx4079\clvertalb\cellx5821\clvertalb\cellx6320\clvertalb\cellx6469\clvertalb\cellx8193\clvertalb\cellx8674\clvertalb\cellx8823\clvertalb\cellx10254\clvertalb\cellx10795\trrh281\row}}}
{\trowd\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx2506\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx3781\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx3930\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4079\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5821\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6320\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6469\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8193\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8674\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8823\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10254\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10795\trrh281
\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\~\~\~\~Corporate bonds\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 69,892\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr \u8212?\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 69,892\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr \u8212?\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx2506\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx3781\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx3930\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4079\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5821\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6320\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6469\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8193\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8674\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8823\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10254\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10795\trrh281\row}}}
{\trowd\clvertalb\cellx2506\clvertalb\cellx3781\clvertalb\cellx3930\clvertalb\cellx4079\clvertalb\cellx5821\clvertalb\cellx6320\clvertalb\cellx6469\clvertalb\cellx8193\clvertalb\cellx8674\clvertalb\cellx8823\clvertalb\cellx10254\clvertalb\cellx10795\trrh281
\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\~\~\~\~Commercial paper\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 11,240\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr \u8212?\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 11,240\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr \u8212?\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalb\cellx2506\clvertalb\cellx3781\clvertalb\cellx3930\clvertalb\cellx4079\clvertalb\cellx5821\clvertalb\cellx6320\clvertalb\cellx6469\clvertalb\cellx8193\clvertalb\cellx8674\clvertalb\cellx8823\clvertalb\cellx10254\clvertalb\cellx10795\trrh281\row}}}
{\trowd\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx2506\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx3781\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx3930\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4079\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5821\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6320\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6469\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8193\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8674\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8823\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10254\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10795\trrh281
\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\~\~\~\~U.S. Treasury securities\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 8,000\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 8,000\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr \u8212?\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr \u8212?\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx2506\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx3781\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx3930\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4079\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5821\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6320\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6469\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8193\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8674\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8823\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10254\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10795\trrh281\row}}}
{\trowd\clvertalb\cellx2506\clvertalb\cellx3781\clvertalb\cellx3930\clvertalb\cellx4079\clvertalb\cellx5821\clvertalb\cellx6320\clvertalb\cellx6469\clvertalb\cellx8193\clvertalb\cellx8674\clvertalb\cellx8823\clvertalb\cellx10254\clvertalb\cellx10795\trrh529
\pard\plain\intbl\li22\ri22\sb22\cf1\f51\fs20\ql \~\~\~\~\~\~\~\~\~\~Total short-term\plain\intbl\li22\ri22\sa22\cf1\f51\fs20\ql investments\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 106,114\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 8,000\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 98,114\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr \u8212?\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalb\cellx2506\clvertalb\cellx3781\clvertalb\cellx3930\clvertalb\cellx4079\clvertalb\cellx5821\clvertalb\cellx6320\clvertalb\cellx6469\clvertalb\cellx8193\clvertalb\cellx8674\clvertalb\cellx8823\clvertalb\cellx10254\clvertalb\cellx10795\trrh529\row}}}
{\trowd\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx2506\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx3930\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4079\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6321\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6470\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8675\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8824\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10796\trrh281
\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql Long-term investments\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell{
{\trowd\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx2506\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx3930\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4079\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6321\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6470\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8675\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8824\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10796\trrh281\row}}}
{\trowd\clvertalb\cellx2506\clvertalb\cellx3781\clvertalb\cellx3930\clvertalb\cellx4079\clvertalb\cellx5821\clvertalb\cellx6320\clvertalb\cellx6469\clvertalb\cellx8193\clvertalb\cellx8674\clvertalb\cellx8823\clvertalb\cellx10254\clvertalb\cellx10795\trrh281
\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\~\~\~\~Certificates of deposit\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 10,996\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr \u8212?\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 10,996\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr \u8212?\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalb\cellx2506\clvertalb\cellx3781\clvertalb\cellx3930\clvertalb\cellx4079\clvertalb\cellx5821\clvertalb\cellx6320\clvertalb\cellx6469\clvertalb\cellx8193\clvertalb\cellx8674\clvertalb\cellx8823\clvertalb\cellx10254\clvertalb\cellx10795\trrh281\row}}}
{\trowd\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx2506\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx3781\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx3930\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4079\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5821\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6320\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6469\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8193\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8674\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8823\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10254\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10795\trrh281
\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\~\~\~\~U.S. Treasury securities\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 40,197\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 40,197\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr \u8212?\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr \u8212?\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx2506\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx3781\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx3930\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4079\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5821\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6320\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6469\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8193\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8674\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8823\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10254\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10795\trrh281\row}}}
{\trowd\clvertalb\cellx2506\clbrdrb\brdrs\brdrcf1\clvertalb\cellx3781\clbrdrb\brdrs\brdrcf1\clvertalb\cellx3930\clvertalb\cellx4079\clbrdrb\brdrs\brdrcf1\clvertalb\cellx5821\clbrdrb\brdrs\brdrcf1\clvertalb\cellx6320\clvertalb\cellx6469\clbrdrb\brdrs\brdrcf1\clvertalb\cellx8193\clbrdrb\brdrs\brdrcf1\clvertalb\cellx8674\clvertalb\cellx8823\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10254\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10795\trrh529
\pard\plain\intbl\li22\ri22\sb22\cf1\f51\fs20\ql \~\~\~\~\~Preferred stock of U.S.\plain\intbl\li22\ri22\sa22\cf1\f51\fs20\ql corporation\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 1,781\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr \u8212?\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr \u8212?\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 1,781\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalb\cellx2506\clbrdrb\brdrs\brdrcf1\clvertalb\cellx3781\clbrdrb\brdrs\brdrcf1\clvertalb\cellx3930\clvertalb\cellx4079\clbrdrb\brdrs\brdrcf1\clvertalb\cellx5821\clbrdrb\brdrs\brdrcf1\clvertalb\cellx6320\clvertalb\cellx6469\clbrdrb\brdrs\brdrcf1\clvertalb\cellx8193\clbrdrb\brdrs\brdrcf1\clvertalb\cellx8674\clvertalb\cellx8823\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10254\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10795\trrh529\row}}}
{\trowd\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx2506\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx3781\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx3930\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4079\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5821\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6320\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6469\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8193\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8674\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8823\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10254\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10795\trrh529
\pard\plain\intbl\li22\ri22\sb22\cf1\f51\fs20\ql \~\~\~\~\~\~\~\~\~\~Total long-term\plain\intbl\li22\ri22\sa22\cf1\f51\fs20\ql investments\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 52,973\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 40,197\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 10,996\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 1,781\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx2506\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx3781\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx3930\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4079\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5821\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6320\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6469\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8193\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8674\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8823\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10254\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10795\trrh529\row}}}
{\trowd\clvertalb\cellx2506\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx2655\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx3780\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx3929\clvertalb\cellx4078\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx4577\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx5819\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx6318\clvertalb\cellx6467\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx6948\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx8190\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx8671\clvertalb\cellx8820\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx9361\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx10250\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx10791\trrh298
\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\~\~\~\~\~\~\~\~\~\~\~\~\~\~Total assets\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\ql $\cell\pard\plain\intbl\sb22\sa22\cf1\f51\fs20\qr 285,173\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\ql $\cell\pard\plain\intbl\sb22\sa22\cf1\f51\fs20\qr 173,803\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\ql $\cell\pard\plain\intbl\sb22\sa22\cf1\f51\fs20\qr 109,590\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\ql $\cell\pard\plain\intbl\sb22\sa22\cf1\f51\fs20\qr 1,781\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalb\cellx2506\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx2655\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx3780\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx3929\clvertalb\cellx4078\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx4577\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx5819\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx6318\clvertalb\cellx6467\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx6948\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx8190\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx8671\clvertalb\cellx8820\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx9361\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx10250\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx10791\trrh298\row}}}
\par\pard\plain\fs16
\par\pard\plain\fs16\pard\plain\cf1\f51\fs20\qc 8
\par\pard\plain\fs16\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par
\page
\par\pard\plain\fs16
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj Below is a table that presents a reconciliation of the beginning and ending balances of assets and liabilities measured at fair value\plain\cf1\f51\fs20\qj on a recurring basis using significant unobservable inputs (Level 3) (in thousands):
\par\pard\plain
{\trowd\trqc\clvertalc\cellx10800\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\trqc\clvertalc\cellx10800\trrh-66\row}}}
{\trowd\trqc\clvertalc\cellx8172\clvertalc\cellx8620\clvertalc\cellx10350\clvertalc\cellx10798\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\trqc\clvertalc\cellx8172\clvertalc\cellx8620\clvertalc\cellx10350\clvertalc\cellx10798\trrh-66\row}}}
{\trowd\trqc\clvertalb\cellx8172\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10799\trrh529
\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\cf1\f51\fs20\b\qc Fair\~Value Measurements
\par\pard\plain\intbl\fs16\pard\plain\intbl\li22\ri22\sa22\cf1\f51\fs20\b\qc (Level\~3)\cell{
{\trowd\trqc\clvertalb\cellx8172\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10799\trrh529\row}}}
{\trowd\trqc\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8172\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10799\trrh281
\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\b\ql Preferred stock of U.S. corporation:\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell{
{\trowd\trqc\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8172\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10799\trrh281\row}}}
{\trowd\trqc\clvertalb\cellx8172\clvertalb\cellx8620\clvertalb\cellx10350\clvertalb\cellx10798\trrh281
\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql Fair value at December 31, 2014\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\ql $\cell\pard\plain\intbl\sb22\sa22\cf1\f51\fs20\qr 1,781\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\trqc\clvertalb\cellx8172\clvertalb\cellx8620\clvertalb\cellx10350\clvertalb\cellx10798\trrh281\row}}}
{\trowd\trqc\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8172\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10350\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10798\trrh281
\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\~\~\~\~Fair value increase recorded in other comprehensive gain\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 61\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\trqc\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8172\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10350\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10798\trrh281\row}}}
{\trowd\trqc\clvertalb\cellx8172\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx8620\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx10350\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx10798\trrh298
\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql Fair value at September 30, 2015\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\ql $\cell\pard\plain\intbl\sb22\sa22\cf1\f51\fs20\qr 1,842\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\trqc\clvertalb\cellx8172\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx8620\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx10350\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx10798\trrh298\row}}}\pard\plain\cf1\f51\fs20\ql \~\~\par\pard\plain\cf1\f51\fs20\b\i\qj Accrued Liabilities
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj Accrued liabilities consisted of the following (in thousands):
\par\pard\plain
{\trowd\trqc\clvertalc\cellx10800\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\trqc\clvertalc\cellx10800\trrh-66\row}}}
{\trowd\trqc\clvertalc\cellx6068\clvertalc\cellx6382\clvertalc\cellx8086\clvertalc\cellx8400\clvertalc\cellx8504\clvertalc\cellx8799\clvertalc\cellx10503\clvertalc\cellx10798\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\trqc\clvertalc\cellx6068\clvertalc\cellx6382\clvertalc\cellx8086\clvertalc\cellx8400\clvertalc\cellx8504\clvertalc\cellx8799\clvertalc\cellx10503\clvertalc\cellx10798\trrh-66\row}}}
{\trowd\trqc\clvertalb\cellx6068\clbrdrb\brdrs\brdrcf1\clvertalb\cellx8400\clvertalb\cellx8504\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10799\trrh281
\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\b\qc September 30, 2015\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\b\qc December 31, 2014\cell{
{\trowd\trqc\clvertalb\cellx6068\clbrdrb\brdrs\brdrcf1\clvertalb\cellx8400\clvertalb\cellx8504\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10799\trrh281\row}}}
{\trowd\trqc\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx6068\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx6382\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx8086\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx8400\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx8504\clbrdrt\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx8799\clbrdrt\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10503\clbrdrt\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10798\trrh298
\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql Accrued compensation\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\ql $\cell\pard\plain\intbl\sb22\sa22\cf1\f51\fs20\qr 3,080\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\ql $\cell\pard\plain\intbl\sb22\sa22\cf1\f51\fs20\qr 3,057\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\trqc\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx6068\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx6382\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx8086\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx8400\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx8504\clbrdrt\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx8799\clbrdrt\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10503\clbrdrt\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10798\trrh298\row}}}
{\trowd\trqc\clvertalb\cellx6068\clvertalb\cellx8086\clvertalb\cellx8400\clvertalb\cellx8504\clvertalb\cellx10503\clvertalb\cellx10798\trrh281
\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql Accrued research and development expenses\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 2,604\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 1,116\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\trqc\clvertalb\cellx6068\clvertalb\cellx8086\clvertalb\cellx8400\clvertalb\cellx8504\clvertalb\cellx10503\clvertalb\cellx10798\trrh281\row}}}
{\trowd\trqc\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx6068\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx8086\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx8400\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx8504\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10503\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10798\trrh281
\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql Deferred revenue\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr \u8212?\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 1,545\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\trqc\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx6068\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx8086\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx8400\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx8504\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10503\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10798\trrh281\row}}}
{\trowd\trqc\clvertalb\cellx6068\clvertalb\cellx8086\clvertalb\cellx8400\clvertalb\cellx8504\clvertalb\cellx10503\clvertalb\cellx10798\trrh281
\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql Other accrued liabilities\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 2,098\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 1,115\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\trqc\clvertalb\cellx6068\clvertalb\cellx8086\clvertalb\cellx8400\clvertalb\cellx8504\clvertalb\cellx10503\clvertalb\cellx10798\trrh281\row}}}
{\trowd\trqc\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx6068\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx6382\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx8086\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx8400\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx8504\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx8799\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10503\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10798\trrh298
\pard\plain\intbl\li330\ri22\sb22\sa22\cf1\f51\fs20\ql Total accrued liabilities\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\ql $\cell\pard\plain\intbl\sb22\sa22\cf1\f51\fs20\qr 7,782\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\ql $\cell\pard\plain\intbl\sb22\sa22\cf1\f51\fs20\qr 6,833\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\trqc\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx6068\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx6382\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx8086\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx8400\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx8504\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx8799\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10503\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10798\trrh298\row}}}
\par\pard\plain\fs16\pard\plain\cf1\f51\fs20\b\i\qj Revenue Recognition
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj The Company\u8217?s revenues generally consist of (i) contract and grant revenue \u8211? revenue generated under federal\plain\cf1\f51\fs20\qj contracts and other awarded grants, and (ii) collaboration and licensing revenue \u8211? revenue related to non-refundable\plain\cf1\f51\fs20\qj upfront fees, royalties and milestone payments earned under license agreements. Revenues are recognized when the following\plain\cf1\f51\fs20\qj criteria are met: (1) persuasive evidence that an arrangement exists; (2) delivery of the products and/or services has occurred; (3)\plain\cf1\f51\fs20\qj the selling price is fixed or determinable; and (4) collectability is reasonably assured.\par\pard\plain\fi792\cf1\f51\fs20\qj \~\par\pard\plain\cf1\f51\fs20\qj For arrangements that involve the delivery of more than one element, each product, service and/or right to use assets is evaluated\plain\cf1\f51\fs20\qj to determine whether it qualifies as a separate unit of accounting. This determination is based on whether the deliverable has\plain\cf1\f51\fs20\qj \u8220?stand-alone value\u8221? to the customer. The consideration that is fixed or determinable is then allocated to each\plain\cf1\f51\fs20\qj separate unit of accounting based on the relative selling prices of each deliverable. The consideration allocated to each unit of\plain\cf1\f51\fs20\qj accounting is recognized as the related goods and services are delivered, limited to the consideration that is not contingent upon\plain\cf1\f51\fs20\qj future deliverables. If the arrangement constitutes a single unit of accounting, the revenue recognition policy must be determined\plain\cf1\f51\fs20\qj for the entire arrangement and the consideration received is recognized over the period of inception through the date the last\plain\cf1\f51\fs20\qj deliverable within the single unit of accounting is expected to be delivered. Revisions to the estimated period of recognition are\plain\cf1\f51\fs20\qj reflected in revenue prospectively.\par\pard\plain\fi792\cf1\f51\fs20\qj \~\~\par\pard\plain\cf1\f51\fs20\qj Non-refundable upfront fees are recorded as deferred revenue and recognized into revenue as license fees from collaborations on\plain\cf1\f51\fs20\qj a straight-line basis over the estimated period of the Company\u8217?s substantive performance obligations. If the Company\plain\cf1\f51\fs20\qj does not have substantive performance obligations, the Company recognizes non-refundable upfront fees into revenue through the\plain\cf1\f51\fs20\qj date the deliverable is satisfied. Analyzing the arrangement to identify deliverables requires the use of judgment and each\plain\cf1\f51\fs20\qj deliverable may be an obligation to deliver services, a right or license to use an asset, or another performance obligation.
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj Milestone payments are recognized when earned, provided that (i) the milestone event is substantive; (ii) there is no ongoing\plain\cf1\f51\fs20\qj performance obligation related to the achievement of the milestone earned; and (iii) it would result in additional payments.\plain\cf1\f51\fs20\qj Milestone payments are considered substantive if all of the following conditions are met: the milestone payment is\plain\cf1\f51\fs20\qj non-refundable; achievement of the milestone was not reasonably assured at the inception of the arrangement; substantive effort\plain\cf1\f51\fs20\qj is involved to achieve the milestone; and the amount of the milestone appears reasonable in relation to the effort expended, the\plain\cf1\f51\fs20\qj other milestones in the arrangement, and the related risk associated with the achievement of the milestone. Contingent based\plain\cf1\f51\fs20\qj event payments the Company may receive under a license or collaboration agreement will be recognized when received.\par\pard\plain\cf1\f51\fs20\ql \~
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qc 9
\par\pard\plain\fs16\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par
\page
\par\pard\plain\fs16
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\b\i\qj Research and Development Prepaids and Accruals
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj As part of the process of preparing financial statements, the Company is required to estimate its expenses resulting from its\plain\cf1\f51\fs20\qj obligation under contracts with vendors and consultants and clinical site agreements in connection with conducting clinical trials.\plain\cf1\f51\fs20\qj The financial terms of these contracts are subject to negotiations that vary contract to contract and may result in payment flows\plain\cf1\f51\fs20\qj that do not match the periods over which materials or services are provided to the Company under such contracts. The\plain\cf1\f51\fs20\qj Company\u8217?s objective is to reflect the appropriate clinical trial expenses in its financial statements by matching those\plain\cf1\f51\fs20\qj expenses with the period in which services and efforts are expended. The Company accounts for these expenses according to the\plain\cf1\f51\fs20\qj progress of the trial as measured by patient progression and the timing of various aspects of the trial. Depending on amounts paid\plain\cf1\f51\fs20\qj to the contract research organization and other third-party vendors as compared to actual expenses incurred, there might be a\plain\cf1\f51\fs20\qj prepaid balance recorded as a prepaid asset. The Company determines accrual estimates through discussion with applicable\plain\cf1\f51\fs20\qj personnel and outside service providers as to the progress or state of completion of trials, or the completion of services. During\plain\cf1\f51\fs20\qj the course of a clinical trial, the Company adjusts its rate of clinical trial expense recognition if actual results differ from its\plain\cf1\f51\fs20\qj estimates. The Company makes estimates of its accrued expenses as of each balance sheet date in its financial statements based\plain\cf1\f51\fs20\qj on facts and circumstances known at that time. Although the Company does not expect its estimates to be materially different\plain\cf1\f51\fs20\qj from amounts actually incurred, its understanding of status and timing of services performed relative to the actual status and\plain\cf1\f51\fs20\qj timing of services performed may vary and may result in the Company reporting amounts that are too high or too low for any\plain\cf1\f51\fs20\qj particular period. Through September\~30, 2015, there had been no material adjustments to the Company\u8217?s prior period\plain\cf1\f51\fs20\qj estimates of accrued expenses for clinical trials. The Company\u8217?s clinical trial accrual is dependent upon the timely and\plain\cf1\f51\fs20\qj accurate reporting of contract research organizations and other third-party vendors.\par\pard\plain\fi792\cf1\f51\fs20\qj \~\par\pard\plain\cf1\f51\fs20\b\i\ql Basic and Diluted Net Loss Per Common Share\plain\cf1\f51\fs20\ql \~
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj Basic net loss per share of common stock is computed by dividing net loss by the weighted-average number of shares of\plain\cf1\f51\fs20\qj common stock outstanding during the period, excluding the dilutive effects of warrants and options to purchase common stock\plain\cf1\f51\fs20\qj and employee stock purchase plan rights. Diluted net loss per common share is computed by dividing net loss by the sum of the\plain\cf1\f51\fs20\qj weighted-average number of shares of common stock outstanding during the period plus the potential dilutive effects of warrants\plain\cf1\f51\fs20\qj and options to purchase common stock outstanding during the period calculated in accordance with the treasury stock method, but\plain\cf1\f51\fs20\qj are excluded if their effect is anti-dilutive. The calculation of weighted-average diluted shares outstanding excludes the dilutive\plain\cf1\f51\fs20\qj effect of warrants and options to purchase common stock and employee stock purchase plan rights, as the impact of such items\plain\cf1\f51\fs20\qj are anti-dilutive during periods of net loss. As a result, there was no difference between basic and diluted net loss per share of\plain\cf1\f51\fs20\qj common stock for the three and nine months ended September\~30, 2015 and 2014. Potential common shares excluded from the\plain\cf1\f51\fs20\qj calculations were 1.1 million and 2.1 million for the three months ended September\~30, 2015 and 2014, respectively, and 1.3\plain\cf1\f51\fs20\qj million and 2.4 million for the nine months ended September\~30, 2015 and 2014, respectively.\par\pard\plain\fi792\cf1\f51\fs20\qj \~\par\pard\plain\cf1\f51\fs20\b\i\ql Impact of Recently Issued Accounting Standards
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj In June\~2014, the Financial Accounting Standards Board (FASB) issued Accounting Standards Update (ASU) No.\~2014-12,\plain\cf1\f51\fs20\qj \u8220?Compensation \u8212? Stock Compensation (Topic 718): Accounting for Share-Based Payments When the Terms of an\plain\cf1\f51\fs20\qj Award Provide That a Performance Target Could Be Achieved after the Requisite Service Period.\u8221? The amendments in\plain\cf1\f51\fs20\qj this update require that a performance target that affects vesting and that could be achieved after the requisite service period\plain\cf1\f51\fs20\qj should be treated as a performance condition. A reporting entity should apply existing guidance in Topic 718 as it relates to\plain\cf1\f51\fs20\qj awards with performance conditions that affect vesting to account for such awards. As such, the performance target should not be\plain\cf1\f51\fs20\qj reflected in estimating the grant-date fair value of the award. ASU 2014-12 is effective for annual periods and interim periods\plain\cf1\f51\fs20\qj within those annual periods beginning after December\~15, 2015. Earlier adoption is permitted. The Company does not expect the\plain\cf1\f51\fs20\qj adoption of ASU 2014-12 to have a material impact on its consolidated financial statements.\par\pard\plain\cf1\f51\fs20\qj \~\par\pard\plain\sb132\cf1\f51\fs20\qj In May 2014, the FASB issued ASU No. 2014-09, "Revenue from Contracts with Customers (Topic 606)." The ASU establishes\plain\cf1\f51\fs20\qj a principles-based approach for accounting for revenue arising from contracts with customers and supersedes existing revenue\plain\cf1\f51\fs20\qj recognition guidance. The ASU provides that an entity should apply a five-step approach for recognizing revenue, including (1)\plain\cf1\f51\fs20\qj identify the contract with a customer; (2) identify the performance obligations in the contract; (3) determine the transaction price;\plain\cf1\f51\fs20\qj (4) allocate the transaction price to the performance obligations in the contract; and (5) recognize revenue when, or as, the entity\plain\cf1\f51\fs20\qj satisfies a performance obligation. Also, the entity must provide various disclosures concerning the nature, amount and timing of\plain\cf1\f51\fs20\qj revenue and cash flows arising from contracts with customers. ASU 2014-09, as amended in ASU No. 2015-14, "Revenue from\plain\cf1\f51\fs20\qj Contracts with Customers (Topic 606)-Deferral of the Effective Date", is effective for public business entities' annual periods and\plain\cf1\f51\fs20\qj interim periods within those annual periods beginning after December 15, 2017. Earlier adoption is permitted for public business\plain\cf1\f51\fs20\qj entities as of annual reporting periods beginning after December 15, 2016, including interim reporting periods within that\plain\sa88\cf1\f51\fs20\qj reporting period. The Company is currently analyzing the impact of this new accounting guidance.
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qc 10
\par\pard\plain\fs16\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par
\page
\par\pard\plain\fs16
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\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj In June 2015, the FASB issued ASU 2015-10,\~\u8220?Technical Corrections and Improvements.\u8221?\plain\cf1\f51\fs20\i\qj \~\~\plain\cf1\f51\fs20\qj The amendments in\plain\cf1\f51\fs20\qj ASU 2015-10\~will clarify and correct some of the difference that arose between original guidance from FASB, EITF and other\plain\cf1\f51\fs20\qj sources, and the translation into the new Codification.\~ASU 2015-10 is effective for annual periods and interim periods within\plain\cf1\f51\fs20\qj those annual periods beginning after December\~15, 2015.\~\~The Company does not expect the adoption of ASU 2015-10 to have a\plain\sa154\cf1\f51\fs20\qj material impact on its consolidated financial statements.
\par\pard\plain\fs16{\*\bkmkstart sAEB6C29EC8E826645B956612944FFBB}{\*\bkmkend sAEB6C29EC8E826645B956612944FFBB}\par\pard\plain\cf1\f51\fs20\b\ql Note 2. Investments\par\pard\plain\fi792\cf1\f51\fs20\qj \~\par\pard\plain\cf1\f51\fs20\qj The following table summarizes the Company's short-term and long-term investments (in thousands):\par\pard\plain\fi792\cf1\f51\fs20\qj \~\~
\par\pard\plain
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\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\b\qc Amortized\~Cost\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\cf1\f51\fs20\b\qc Gross\~\plain\intbl\li22\ri22\sa22\cf1\f51\fs20\b\qc Unrealized\~Gains\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\cf1\f51\fs20\b\qc Gross\~\plain\intbl\li22\ri22\sa22\cf1\f51\fs20\b\qc Unrealized\~Losses\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\b\qc Estimated\~Fair\~Value\cell{
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\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql Corporate bonds\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\ql $\cell\pard\plain\intbl\sb22\sa22\cf1\f51\fs20\qr 3,001\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\ql $\cell\pard\plain\intbl\sb22\sa22\cf1\f51\fs20\qr \u8212?\cell
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\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql Certificates of deposit\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 38,884\cell
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\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql U.S. Treasury securities\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 291,672\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 147\cell
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\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell{
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\pard\plain\intbl\li22\ri22\sb22\cf1\f51\fs20\ql Preferred stock of U.S.\plain\intbl\li22\ri22\sa22\cf1\f51\fs20\ql corporation\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 1,545\cell
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\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell{
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\pard\plain\intbl\li330\ri22\sb22\sa22\cf1\f51\fs20\ql Total investments\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\ql $\cell\pard\plain\intbl\sb22\sa22\cf1\f51\fs20\qr 335,102\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\ql $\cell\pard\plain\intbl\sb22\sa22\cf1\f51\fs20\qr 476\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\ql $\cell\pard\plain\intbl\sb22\sa22\cf1\f51\fs20\qr (12\cell\pard\plain\intbl\ri22\sb22\sa22\cf1\f51\fs20\ql )\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\ql $\cell\pard\plain\intbl\sb22\sa22\cf1\f51\fs20\qr 335,566\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx2968\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx3053\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx3509\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4306\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4762\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4855\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5379\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6172\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6696\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6789\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7331\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8124\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8666\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8759\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9376\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10173\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10790\trrh298\row}}}
{\trowd\clvertalb\cellx2968\clvertalb\cellx3053\clvertalb\cellx4763\clvertalb\cellx4856\clvertalb\cellx6698\clvertalb\cellx6791\clvertalb\cellx8670\clvertalb\cellx8763\clvertalb\cellx10795\trrh371
\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell{
{\trowd\clvertalb\cellx2968\clvertalb\cellx3053\clvertalb\cellx4763\clvertalb\cellx4856\clvertalb\cellx6698\clvertalb\cellx6791\clvertalb\cellx8670\clvertalb\cellx8763\clvertalb\cellx10795\trrh371\row}}}
{\trowd\clvertalb\cellx2968\clvertalb\cellx3053\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10798\trrh281
\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\b\qc December 31, 2014\cell{
{\trowd\clvertalb\cellx2968\clvertalb\cellx3053\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10798\trrh281\row}}}
{\trowd\clvertalb\cellx2968\clvertalb\cellx3053\clbrdrb\brdrs\brdrcf1\clvertalb\cellx4763\clvertalb\cellx4856\clbrdrb\brdrs\brdrcf1\clvertalb\cellx6698\clvertalb\cellx6791\clbrdrb\brdrs\brdrcf1\clvertalb\cellx8670\clvertalb\cellx8763\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10795\trrh529
\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\b\qc Amortized\~Cost\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\cf1\f51\fs20\b\qc Gross\~\plain\intbl\li22\ri22\sa22\cf1\f51\fs20\b\qc Unrealized\~Gains\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\cf1\f51\fs20\b\qc Gross\~\plain\intbl\li22\ri22\sa22\cf1\f51\fs20\b\qc Unrealized\~Losses\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\b\qc Estimated\~Fair\~Value\cell{
{\trowd\clvertalb\cellx2968\clvertalb\cellx3053\clbrdrb\brdrs\brdrcf1\clvertalb\cellx4763\clvertalb\cellx4856\clbrdrb\brdrs\brdrcf1\clvertalb\cellx6698\clvertalb\cellx6791\clbrdrb\brdrs\brdrcf1\clvertalb\cellx8670\clvertalb\cellx8763\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10795\trrh529\row}}}
{\trowd\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx2968\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx3053\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx3509\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4306\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4762\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4855\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5379\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6172\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6696\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6789\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7331\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8124\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8666\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8759\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9376\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10173\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10790\trrh281
\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql Corporate bonds\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\ql $\cell\pard\plain\intbl\sb22\sa22\cf1\f51\fs20\qr 69,947\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\ql $\cell\pard\plain\intbl\sb22\sa22\cf1\f51\fs20\qr \u8212?\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\ql $\cell\pard\plain\intbl\sb22\sa22\cf1\f51\fs20\qr (56\cell\pard\plain\intbl\ri22\sb22\sa22\cf1\f51\fs20\ql )\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\ql $\cell\pard\plain\intbl\sb22\sa22\cf1\f51\fs20\qr 69,891\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx2968\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx3053\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx3509\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4306\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4762\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4855\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx5379\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6172\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6696\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6789\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx7331\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8124\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8666\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8759\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9376\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10173\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10790\trrh281\row}}}
{\trowd\clvertalb\cellx2968\clvertalb\cellx3053\clvertalb\cellx4306\clvertalb\cellx4762\clvertalb\cellx4855\clvertalb\cellx6173\clvertalb\cellx6697\clvertalb\cellx6790\clvertalb\cellx8126\clvertalb\cellx8668\clvertalb\cellx8761\clvertalb\cellx10175\clvertalb\cellx10792\trrh281
\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql Certificates of deposit\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 28,039\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 1\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr (62\cell\pard\plain\intbl\ri22\sb22\sa22\cf1\f51\fs20\ql )\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 27,978\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalb\cellx2968\clvertalb\cellx3053\clvertalb\cellx4306\clvertalb\cellx4762\clvertalb\cellx4855\clvertalb\cellx6173\clvertalb\cellx6697\clvertalb\cellx6790\clvertalb\cellx8126\clvertalb\cellx8668\clvertalb\cellx8761\clvertalb\cellx10175\clvertalb\cellx10792\trrh281\row}}}
{\trowd\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx2968\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx3053\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4306\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4762\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4855\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6173\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6697\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6790\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8126\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8668\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8761\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10175\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10792\trrh281
\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql U.S. Treasury securities\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 48,279\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr \u8212?\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr (82\cell\pard\plain\intbl\ri22\sb22\sa22\cf1\f51\fs20\ql )\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 48,197\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx2968\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx3053\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4306\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4762\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4855\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6173\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6697\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6790\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8126\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8668\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8761\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10175\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10792\trrh281\row}}}
{\trowd\clvertalb\cellx2968\clvertalb\cellx3053\clvertalb\cellx4306\clvertalb\cellx4762\clvertalb\cellx4855\clvertalb\cellx6173\clvertalb\cellx6697\clvertalb\cellx6790\clvertalb\cellx8126\clvertalb\cellx8668\clvertalb\cellx8761\clvertalb\cellx10175\clvertalb\cellx10792\trrh281
\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql Commercial paper\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 11,242\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr \u8212?\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr (2\cell\pard\plain\intbl\ri22\sb22\sa22\cf1\f51\fs20\ql )\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 11,240\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalb\cellx2968\clvertalb\cellx3053\clvertalb\cellx4306\clvertalb\cellx4762\clvertalb\cellx4855\clvertalb\cellx6173\clvertalb\cellx6697\clvertalb\cellx6790\clvertalb\cellx8126\clvertalb\cellx8668\clvertalb\cellx8761\clvertalb\cellx10175\clvertalb\cellx10792\trrh281\row}}}
{\trowd\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx2968\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx3053\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4306\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4762\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4855\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6173\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6697\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6790\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8126\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8668\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8761\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10175\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10792\trrh529
\pard\plain\intbl\li22\ri22\sb22\cf1\f51\fs20\ql Preferred stock of U.S.\plain\intbl\li22\ri22\sa22\cf1\f51\fs20\ql corporation\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 1,545\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 236\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr \u8212?\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 1,781\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx2968\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx3053\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4306\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4762\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx4855\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6173\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6697\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx6790\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8126\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8668\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx8761\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10175\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10792\trrh529\row}}}
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\pard\plain\intbl\li330\ri22\sb22\sa22\cf1\f51\fs20\ql Total investments\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\ql $\cell\pard\plain\intbl\sb22\sa22\cf1\f51\fs20\qr 159,052\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\ql $\cell\pard\plain\intbl\sb22\sa22\cf1\f51\fs20\qr 237\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\ql $\cell\pard\plain\intbl\sb22\sa22\cf1\f51\fs20\qr (202\cell\pard\plain\intbl\ri22\sb22\sa22\cf1\f51\fs20\ql )\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\ql $\cell\pard\plain\intbl\sb22\sa22\cf1\f51\fs20\qr 159,087\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalb\cellx2968\clvertalb\cellx3053\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx3509\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx4306\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx4762\clvertalb\cellx4855\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx5379\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx6172\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx6696\clvertalb\cellx6789\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx7331\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx8124\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx8666\clvertalb\cellx8759\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx9376\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx10173\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx10790\trrh298\row}}}\pard\plain\fi792\cf1\f51\fs20\qj \~\par\pard\plain\cf1\f51\fs20\qj The Company periodically reviews available-for-sale securities for other-than-temporary declines in fair value below the cost\plain\cf1\f51\fs20\qj basis and whenever events or changes in circumstances indicate that the carrying amount of an asset may not be recoverable. The\plain\cf1\f51\fs20\qj Company evaluates, among other things, the duration and extent to which the fair value of a security is less than its cost; the\plain\cf1\f51\fs20\qj financial condition of the issuer and any changes thereto; and the Company\u8217?s intent to sell, or whether it will more likely\plain\cf1\f51\fs20\qj than not be required to sell, the security before recovery of its amortized cost basis. Any such declines in value judged to be\plain\cf1\f51\fs20\qj other-than temporary on available-for-sale securities are reported in interest income or expense, net. There were no such\plain\cf1\f51\fs20\qj declines in value for the three and nine months ended September\~30, 2015 and 2014.
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\ql The following table summarizes the scheduled maturity for the Company's debt investments at September\~30, 2015 (in\plain\cf1\f51\fs20\ql thousands):
\par\pard\plain\fs16
\par\pard\plain
{\trowd\trqc\clvertalc\cellx10800\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\trqc\clvertalc\cellx10800\trrh-66\row}}}
{\trowd\trqc\clvertalc\cellx9600\clvertalc\cellx9720\clvertalc\cellx10691\clvertalc\cellx10798\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\trqc\clvertalc\cellx9600\clvertalc\cellx9720\clvertalc\cellx10691\clvertalc\cellx10798\trrh-66\row}}}
{\trowd\trqc\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9600\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9720\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10691\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10798\trrh281
\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql Maturing in one year or less\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\ql $\cell\pard\plain\intbl\sb22\sa22\cf1\f51\fs20\qr 174,238\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\trqc\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9600\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9720\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10691\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10798\trrh281\row}}}
{\trowd\trqc\clvertalb\cellx9600\clvertalb\cellx10691\clvertalb\cellx10798\trrh281
\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql Maturing after one year through two years\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 159,486\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\trqc\clvertalb\cellx9600\clvertalb\cellx10691\clvertalb\cellx10798\trrh281\row}}}
{\trowd\trqc\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9600\clbrdrt\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10691\clbrdrt\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10798\trrh298
\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\~\~\~\~Total debt investments\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 333,724\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\trqc\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9600\clbrdrt\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10691\clbrdrt\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10798\trrh298\row}}}
{\trowd\trqc\clvertalb\cellx9600\clvertalb\cellx10691\clvertalb\cellx10798\trrh281
\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql Preferred stock of U.S. corporation\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 1,842\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\trqc\clvertalb\cellx9600\clvertalb\cellx10691\clvertalb\cellx10798\trrh281\row}}}
{\trowd\trqc\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9600\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9720\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10691\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10798\trrh298
\pard\plain\intbl\li330\ri22\sb22\sa22\cf1\f51\fs20\ql Total investments\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\ql $\cell\pard\plain\intbl\sb22\sa22\cf1\f51\fs20\qr 335,566\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\trqc\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9600\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx9720\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10691\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrdb\brdrcf1\clvertalb\clshdng100\clcfpat11\clcbpat11\cellx10798\trrh298\row}}}
\par\pard\plain\fs16\pard\plain\fi792\cf1\f51\fs20\ql \~
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qc 11
\par\pard\plain\fs16\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par
\page{\*\bkmkstart s13E05F1055DE7859E41266129423CC8}{\*\bkmkend s13E05F1055DE7859E41266129423CC8}
\par\pard\plain\fs16
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\b\qj Note 3. Loan Payable
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj On January 27, 2012, the Company entered into a Loan and Security Agreement (LSA) with Silicon Valley Bank and MidCap\plain\cf1\f51\fs20\qj Financial SBIC, LP allowing for borrowings up to $15.0 million, split between a first tranche of $3.0 million borrowed at the\plain\cf1\f51\fs20\qj time of the agreement, and a second tranche of up to $12.0 million. The borrowings under the LSA were collateralized by a\plain\cf1\f51\fs20\qj security interest in all of the Company\u8217?s assets, excluding its intellectual property.\par\pard\plain\fi792\cf1\f51\fs20\qj \~\par\pard\plain\cf1\f51\fs20\qj The first tranche, which was paid in full as of June 30, 2015, had an interest-only period of twelve months followed by a\plain\cf1\f51\fs20\qj principal and interest amortization period of 30 months with interest being charged at 8.25% per year. The second tranche, which\plain\cf1\f51\fs20\qj had an outstanding principal balance of $0.4 million as of September\~30, 2015, had an interest-only period of 6 months followed\plain\cf1\f51\fs20\qj by a principal and interest amortization period of 32 months with interest being charged at 8.25%. There were certain fees in\plain\cf1\f51\fs20\qj accordance with the LSA which were recorded as discounts or short-term liabilities depending on the nature of the fees and\plain\cf1\f51\fs20\qj accreted through interest expense over the life of the loans. As of October 14, 2015, the LSA was paid in full and no amounts\plain\cf1\f51\fs20\qj remain outstanding.\par\pard\plain\fi792\cf1\f51\fs20\qj \~{\*\bkmkstart s582FE52F9C9A270C69666612942C4A1}{\*\bkmkend s582FE52F9C9A270C69666612942C4A1}\par\pard\plain\cf1\f51\fs20\b\qj Note 4. Commitments and Contingencies\par\pard\plain\fi792\cf1\f51\fs20\b\i\qj \~\par\pard\plain\cf1\f51\fs20\b\i\qj Leases
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj The Company leases its facilities and certain office equipment under long-term non-cancelable operating leases that expire at\plain\cf1\f51\fs20\qj various dates through 2021. Rent expense under non-cancelable operating leases and other month-to-month equipment rental\plain\cf1\f51\fs20\qj agreements, including common area maintenance fees, totaled approximately $0.2 million and $0.1 million for the three months\plain\cf1\f51\fs20\qj ended September\~30, 2015 and 2014, respectively, and $0.5 million and $0.4 million for the nine months ended September\~30,\plain\cf1\f51\fs20\qj 2015 and 2014, respectively.\par\pard\plain\fi792\cf1\f51\fs20\b\i\qj \~\par\pard\plain\cf1\f51\fs20\b\i\qj Significance of Revenue Source
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj The Company is the recipient of federal research contract funds from the Biomedical Advanced Research and Development\plain\cf1\f51\fs20\qj Authority (BARDA), the primary source of the Company's contract revenue. Periodic audits are required under the\plain\cf1\f51\fs20\qj Company\u8217?s BARDA agreement and certain costs may be questioned as appropriate under the BARDA agreement.\plain\cf1\f51\fs20\qj Management believes that such amounts in the current year, if any, are not significant. Accordingly, no provision for refundable\plain\cf1\f51\fs20\qj amounts under the BARDA agreement has been made as of September\~30, 2015 and December\~31, 2014.\par\pard\plain\fi792\cf1\f51\fs20\qj \~{\*\bkmkstart s181496D0DCB385CDB346661294357D5}{\*\bkmkend s181496D0DCB385CDB346661294357D5}\par\pard\plain\cf1\f51\fs20\b\qj Note 5. Equity Transactions and Share-based Compensation
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\b\i\qj Common Stock
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj On June 16, 2015, the Company completed an underwritten public offering of 4,341,250 shares of common stock, including\plain\cf1\f51\fs20\qj 566,250 shares sold pursuant to the full exercise of an option granted to the underwriters to purchase additional shares of\plain\cf1\f51\fs20\qj common stock. All of the shares were offered by the Company at a price to the public of $39.75 per share. The net proceeds\plain\cf1\f51\fs20\qj from this offering, after deducting underwriting discounts and commissions and other offering expenses payable by the Company,\plain\cf1\f51\fs20\qj were approximately $161.9 million.
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\b\i\qj Warrants
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj For the three months ended September\~30, 2015 warrants for the purchase of 0.2 million shares of common stock were exercised\plain\cf1\f51\fs20\qj with no net proceeds to the Company. For the nine months ended September\~30, 2015, warrants for the purchase of 0.4 million\plain\cf1\f51\fs20\qj shares of common stock were exercised resulting in $1.0 million in proceeds to the Company.
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\b\i\qj Stock Options
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj In connection with the Company\u8217?s IPO, the Company adopted the 2013 Equity Incentive Plan (the 2013 Plan). The 2013\plain\cf1\f51\fs20\qj Plan provides for the grant of incentive stock options (ISOs), nonstatutory stock options (NSOs), stock appreciation rights,\plain\cf1\f51\fs20\qj restricted stock awards, restricted stock unit (RSU) awards, performance-based stock awards, and other forms of equity\plain\cf1\f51\fs20\qj compensation (collectively, stock awards), all of which may be granted to employees, including officers, non-employee directors\plain\cf1\f51\fs20\qj and consultants of the Company and its affiliates. Additionally, the 2013 Plan provides for the grant of performance cash awards.\plain\cf1\f51\fs20\qj The number of shares of common stock reserved for future issuance automatically increases on January 1 of each calendar year\plain\cf1\f51\fs20\qj by 4% of the total number of shares of capital stock outstanding on December 31 of the preceding calendar year, or a lesser\plain\cf1\f51\fs20\qj number of shares determined by the Company\u8217?s board of directors. On January 1, 2015, the common stock reserved for\plain\cf1\f51\fs20\qj issuance under the 2013
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qc 12
\par\pard\plain\fs16\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par
\page
\par\pard\plain\fs16
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj Plan was automatically increased by 1.6 million shares.\~As of September\~30, 2015, there was a total of 1.6 million shares\plain\cf1\f51\fs20\qj reserved for future issuance under the 2013 Plan.
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\b\i\qj Employee Stock Purchase Plan\par\pard\plain\cf1\f51\fs20\qj \~\par\pard\plain\cf1\f51\fs20\qj In February 2013, the Company\u8217?s board of directors adopted the 2013 Employee Stock Purchase Plan (ESPP), which was\plain\cf1\f51\fs20\qj subsequently ratified by stockholders and became effective in April 2013. Initially, the ESPP authorized the issuance of 704,225\plain\cf1\f51\fs20\qj shares of common stock pursuant to purchase rights granted to the Company\u8217?s employees or to employees of any of its\plain\cf1\f51\fs20\qj designated affiliates. The number of shares of common stock reserved for issuance automatically increases on January 1 of each\plain\cf1\f51\fs20\qj calendar year, from January 1, 2014 through January 1, 2023 by the lesser of (a) 1% of the total number of shares of common\plain\cf1\f51\fs20\qj stock outstanding on December 31 of the preceding calendar year, (b) 422,535 shares, or (c) a number determined by the\plain\cf1\f51\fs20\qj Company\u8217?s board of directors that is less than (a) and (b).\~ On January 1, 2015, the common stock reserved for issuance\plain\cf1\f51\fs20\qj under the ESPP was automatically increased by an additional 0.4 million shares bringing the total number of shares of common\plain\cf1\f51\fs20\qj stock that may be purchased under the ESPP to 1.4 million.
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj The Company has reserved a total of 1.4 million shares of common stock to be purchased under the ESPP, of which 1.3 million\plain\cf1\f51\fs20\qj shares remained available for purchase as of September\~30, 2015. The ESPP provides for an automatic reset feature to start\plain\cf1\f51\fs20\qj participants on a new twenty-four month participation period in the event that the common stock market value on a purchase\plain\cf1\f51\fs20\qj date is less than the common stock value on the first day of the twenty-four month offering period. Eligible employees may\plain\cf1\f51\fs20\qj authorize an amount up to 15% of their salary to purchase common stock at the lower of a 15% discount to the beginning price\plain\cf1\f51\fs20\qj of their offering period or a 15% discount to the ending price of each six-month purchase interval. The Company issued\plain\cf1\f51\fs20\qj approximately 31,000 and 12,000 shares of common stock pursuant to the ESPP for the three months ended September\~30, 2015\plain\cf1\f51\fs20\qj and 2014, respectively. The Company issued approximately 57,000 and 26,000 shares of common stock pursuant to the ESPP for\plain\cf1\f51\fs20\qj the nine months ended September\~30, 2015 and 2014, respectively. Compensation expense for shares purchased under the ESPP\plain\cf1\f51\fs20\qj related to the purchase discount and the \u8220?look-back\u8221? option were determined using a Black-Scholes option pricing\plain\cf1\f51\fs20\qj model.
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj For awards with only service conditions and graded-vesting features, the Company recognizes compensation expense on a\plain\cf1\f51\fs20\qj straight-line basis over the requisite service period. For the three and nine months ended September\~30, 2015 and 2014, there\plain\cf1\f51\fs20\qj was no non-employee share-based compensation expense. Employee share-based compensation expense recognized related to\plain\cf1\f51\fs20\qj stock options and the ESPP is as follows (in thousands):\par\pard\plain\fi792\cf1\f51\fs20\qj \~
\par\pard\plain
{\trowd\clvertalc\cellx10799\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell{
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\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\cf1\f51\fs20\b\qc Three Months Ended\plain\intbl\li22\sa22\cf1\f51\fs20\b\qc September 30,\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\cf1\f51\fs20\b\qc Nine Months Ended\plain\intbl\li22\sa22\cf1\f51\fs20\b\qc September 30,\cell{
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\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\b\qc 2015\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\b\qc 2014\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\b\qc 2015\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\b\qc 2014\cell{
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\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql Research and development expense\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\ql $\cell\pard\plain\intbl\sb22\sa22\cf1\f51\fs20\qr 1,594\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\ql $\cell\pard\plain\intbl\sb22\sa22\cf1\f51\fs20\qr 524\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\ql $\cell\pard\plain\intbl\sb22\sa22\cf1\f51\fs20\qr 3,820\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\ql $\cell\pard\plain\intbl\sb22\sa22\cf1\f51\fs20\qr 428\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell{
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\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql General and administrative expense\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 2,085\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 838\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 5,062\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 2,349\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell{
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\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\~\~\~\~\~\~\~\~\~Total share-based compensation expense\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\ql $\cell\pard\plain\intbl\sb22\sa22\cf1\f51\fs20\qr 3,679\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\ql $\cell\pard\plain\intbl\sb22\sa22\cf1\f51\fs20\qr 1,362\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\ql $\cell\pard\plain\intbl\sb22\sa22\cf1\f51\fs20\qr 8,882\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\ql $\cell\pard\plain\intbl\sb22\sa22\cf1\f51\fs20\qr 2,777\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell{
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\par\pard\plain\fs16{\*\bkmkstart sE31DD5878CF049FD963666129470C68}{\*\bkmkend sE31DD5878CF049FD963666129470C68}\pard\plain\cf1\f51\fs20\b\qj Note 6. Income Taxes\par\pard\plain\fi792\cf1\f51\fs20\b\qj \~\par\pard\plain\cf1\f51\fs20\qj The Company estimates an annual effective tax rate of 0% for the year ending December 31, 2015 as the Company incurred\plain\cf1\f51\fs20\qj losses for the nine month period ended September\~30, 2015 and is forecasting additional losses through the fourth quarter,\plain\cf1\f51\fs20\qj resulting in an estimated net loss for both financial statement and tax purposes for the year ending December 31, 2015.\plain\cf1\f51\fs20\qj Therefore, no federal or state income taxes are expected and none have been recorded at this time. Income taxes have been\plain\cf1\f51\fs20\qj accounted for using the liability method in accordance with FASB Accounting Standards Codification 740.
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj Due to the Company's history of losses since inception, there is not enough evidence at this time to support that the Company\plain\cf1\f51\fs20\qj will generate future income of a sufficient amount and nature to utilize the benefits of its net deferred tax assets. Accordingly, the\plain\cf1\f51\fs20\qj deferred tax assets have been reduced by a full valuation allowance, since the Company does not currently believe that realization\plain\cf1\f51\fs20\qj of its deferred tax assets is more likely than not.\par\pard\plain\cf1\f51\fs20\qj \~\par\pard\plain\cf1\f51\fs20\qj As of September\~30, 2015, the Company had no unrecognized tax benefits that would reduce the Company\u8217?s effective tax\plain\cf1\f51\fs20\qj rate if recognized.\par\pard\plain\fi792\cf1\f51\fs20\b\ql \~{\*\bkmkstart sEAE3A5280A232DCFAE8B66129442AE5}{\*\bkmkend sEAE3A5280A232DCFAE8B66129442AE5}\par\pard\plain\cf1\f51\fs20\b\ql Note 7. Significant Agreements\par\pard\plain\fi792\cf1\f51\fs20\ql \~\~\par\pard\plain\cf1\f51\fs20\b\i\qj The Regents of the University of California
\par\pard\plain\fs16
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qc 13
\par\pard\plain\fs16\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par
\page
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\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj In May 2002, the Company entered into a license agreement with The Regents of the University of California (UC) under which\plain\cf1\f51\fs20\qj the Company obtained an exclusive, worldwide license to UC\u8217?s patent rights in certain inventions (the UC Patent Rights)\plain\cf1\f51\fs20\qj related to lipid-conjugated antiviral compounds and their use, including certain patents relating to brincidofovir.\par\pard\plain\fi792\cf1\f51\fs20\qj \~\~\par\pard\plain\cf1\f51\fs20\qj Under the license agreement, the Company is permitted to research, develop, manufacture and commercialize products utilizing\plain\cf1\f51\fs20\qj the UC Patent Rights for all human and veterinary uses, and to sublicense such rights. UC retained the right, on behalf of itself\plain\cf1\f51\fs20\qj and other non-profit institutions, to use the UC Patent Rights for educational and research purposes and to publish information\plain\cf1\f51\fs20\qj about the UC Patent Rights.\par\pard\plain\fi792\cf1\f51\fs20\qj \~\par\pard\plain\cf1\f51\fs20\qj In consideration for the rights granted under the license agreement, the Company has issued UC an aggregate of 64,788 shares of\plain\cf1\f51\fs20\qj common stock. As additional consideration, the Company is required to pay certain cash milestone payments in connection with\plain\cf1\f51\fs20\qj the development and commercialization of compounds that are covered by the UC Patent Rights, plus certain annual fees to\plain\cf1\f51\fs20\qj maintain such patents until the Company commercializes a product utilizing UC Patent Rights. In connection with the\plain\cf1\f51\fs20\qj development and commercialization of brincidofovir, the Company could be required to pay UC up to an aggregate of $3.4\plain\cf1\f51\fs20\qj million in milestone payments, assuming the achievement of all applicable milestone events under the license agreement. In\plain\cf1\f51\fs20\qj addition, upon commercialization of any product utilizing the UC Patent Rights (which would include the commercialization of\plain\cf1\f51\fs20\qj brincidofovir), the Company will be required to pay low single digit royalties on net sales of such product.\par\pard\plain\fi792\cf1\f51\fs20\qj \~\par\pard\plain\cf1\f51\fs20\qj In the event the Company sublicenses a UC Patent Right (including UC Patent Rights relating to brincidofovir) the Company is\plain\cf1\f51\fs20\qj obligated to pay to UC a fee, which amount will vary depending upon the amount of any payments the Company receives and\plain\cf1\f51\fs20\qj the clinical development stage of the compound being sublicensed, but which could be up to approximately 50% of the\plain\cf1\f51\fs20\qj sublicense fee in certain circumstances. With respect to brincidofovir, the fee payable to UC will not exceed 5% of the sublicense\plain\cf1\f51\fs20\qj fee. In addition, the Company will also be required to pay to UC a low single digit sublicense royalty on net sales of products\plain\cf1\f51\fs20\qj that use the sublicensed UC Patent Rights, but in no event will the Company be required to pay more than 50% of the royalties\plain\cf1\f51\fs20\qj it receives in connection with the relevant sublicense. Any such royalty payment will be reduced by other payments the Company\plain\cf1\f51\fs20\qj is required to make to third parties until a minimum royalty has been reached.\par\pard\plain\fi792\cf1\f51\fs20\qj \~\par\pard\plain\cf1\f51\fs20\qj The Company did not recognize expenses under this agreement for the three and nine months ended September\~30, 2015 and\plain\cf1\f51\fs20\qj 2014.\par\pard\plain\fi792\cf1\f51\fs20\b\i\qj \~\plain\cf1\f51\fs20\qj \~\par\pard\plain\cf1\f51\fs20\b\i\qj Biomedical Advanced Research and Development Authority
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj In February 2011, the Company entered into a contract with BARDA for the development of brincidofovir as a medical\plain\cf1\f51\fs20\qj countermeasure in the event of a smallpox release. The contract has been amended several times. In July 2015, the contract was\plain\cf1\f51\fs20\qj amended to extend the period of performance for the second option segment through June 30, 2016. In September 2015, the third\plain\cf1\f51\fs20\qj option segment of the contract to provide approximately $13 million through October 31, 2016 was executed.\par\pard\plain\fi792\cf1\f51\fs20\qj \~\par\pard\plain\cf1\f51\fs20\qj Under the contract, BARDA will reimburse the Company, plus pay a fixed fee, for the research and development of brincidofovir\plain\cf1\f51\fs20\qj as a treatment for smallpox infections. The contract consists of an initial performance period, referred to as the base performance\plain\cf1\f51\fs20\qj segment, plus up to four extension periods, referred to as option segments, each of which may be exercised at BARDA\u8217?s\plain\cf1\f51\fs20\qj sole discretion. Under the contract as currently in effect, the Company may cumulatively receive up to $75.8 million in expense\plain\cf1\f51\fs20\qj reimbursement and $5.3 million in fees if all remaining option segments are exercised. As of September\~30, 2015, we had\plain\cf1\f51\fs20\qj recognized revenue in aggregate of $42.8 million with respect to the base performance segment and the first three extension\plain\cf1\f51\fs20\qj periods.\par\pard\plain\fi792\cf1\f51\fs20\qj \~\par\pard\plain\cf1\f51\fs20\qj For the three months ended September\~30, 2015 and 2014, the Company recognized revenue under this contract of $2.3 million\plain\cf1\f51\fs20\qj and $1.2 million, respectively, and for the nine months ended September\~30, 2015 and 2014, the Company recognized revenue\plain\cf1\f51\fs20\qj under this contract of $6.1 million and $2.9 million, respectively.
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\b\i\qj ContraVir Pharmaceuticals
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj On December 17, 2014, the Company entered into a license agreement with ContraVir Pharmaceuticals (NASDAQ: CTRV) for\plain\cf1\f51\fs20\qj the development and commercialization of CMX157, our clinical stage nucleotide analog, for certain antiviral indications. Under\plain\cf1\f51\fs20\qj the terms of the agreement, ContraVir has sole responsibility with respect to the control of the development and\plain\cf1\f51\fs20\qj commercialization of CMX157.
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj In exchange for the license to CMX157 rights, the Company received an upfront payment consisting of 120,000 shares of\plain\cf1\f51\fs20\qj ContraVir Series B Convertible Preferred Stock with a stated value of $1.2 million. In addition, the Company is eligible to\plain\cf1\f51\fs20\qj receive up to approximately $20.0 million in clinical, regulatory and initial commercial milestones in the United States and\plain\cf1\f51\fs20\qj Europe, as well as royalties and additional milestones based on commercial sales in those territories. Either party may terminate\plain\cf1\f51\fs20\qj the license agreement upon the occurrence of a material breach by the other party (subject to standard cure periods), or upon\plain\cf1\f51\fs20\qj certain events involving
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\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj the bankruptcy or insolvency of the other party. ContraVir may also terminate the license agreement without cause on a\plain\cf1\f51\fs20\qj country-by-country basis upon 60 days\u8217? prior written notice.
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj The upfront payment of 120,000 shares of ContraVir Series B Convertible Preferred Stock was valued at $1.5 million at the time\plain\cf1\f51\fs20\qj of the agreement. During the fourth quarter of 2014, the Company recorded this amount as a long-term investment and deferred\plain\cf1\f51\fs20\qj revenue, which was included in accrued liabilities in the Consolidated Balance Sheets. Upon the completion of the transfer of the\plain\cf1\f51\fs20\qj investigational new drug (IND) and technical know-how related to CMX157, the Company recognized the upfront payment as\plain\cf1\f51\fs20\qj revenue during the three months ended June\~30, 2015. As of September\~30, 2015 and December\~31, 2014, the fair value of the\plain\cf1\f51\fs20\qj investment was $1.8 million.\par\pard\plain\cf1\f51\fs20\qj \~{\*\bkmkstart s8BE7997FED9691132355661294485CD}{\*\bkmkend s8BE7997FED9691132355661294485CD}\par\pard\plain\cf1\f51\fs20\b\ql Note 8. Subsequent Events
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj The Company has evaluated subsequent events through the issuance date of these financial statements to ensure that this filing\plain\cf1\f51\fs20\qj includes appropriate disclosure of events both recognized in the financial statements as of September\~30, 2015, and events which\plain\cf1\f51\fs20\qj occurred subsequently but were not recognized in the financial statements.
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\par\pard\plain\fs16{\*\bkmkstart item_1_3_2}{\*\bkmkend item_1_3_2}\par\pard\plain\cf1\f51\fs20\b\ql ITEM 2. \~\~\~\~MANAGEMENT\u8217?S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS\plain\cf1\f51\fs20\b\ql OF OPERATIONS\par\pard\plain\fi792\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\i\qj The following discussion and analysis of our financial condition and results of operations should be read in conjunction with our\plain\cf1\f51\fs20\i\qj unaudited condensed financial statements and related notes included in this Quarterly Report on Form 10-Q and the audited\plain\cf1\f51\fs20\i\qj financial statements and notes thereto as of and for the year ended December 31, 2014 and the related Management\u8217?s\plain\cf1\f51\fs20\i\qj Discussion and Analysis of Financial Condition and Results of Operations, both of which are contained in our Annual Report on\plain\cf1\f51\fs20\i\qj Form 10-K for the year ended December 31, 2014, filed with the Securities and Exchange Commission (SEC) on March 6, 2015,\plain\cf1\f51\fs20\i\qj and amended on March 27, 2015. Past operating results are not necessarily indicative of results that may occur in future\plain\cf1\f51\fs20\i\qj periods.\par\pard\plain\fi792\cf1\f51\fs20\i\qj \~\par\pard\plain\cf1\f51\fs20\b\i\ql Forward-Looking Statements\par\pard\plain\cf1\f51\fs20\i\qj The information in this discussion contains forward-looking statements and information within the meaning of Section 27A of the\plain\cf1\f51\fs20\i\qj Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended, or the Exchange Act,\plain\cf1\f51\fs20\i\qj which are subject to the \u8220?safe harbor\u8221? created by those sections. These forward-looking statements include, but are\plain\cf1\f51\fs20\i\qj not limited to, statements concerning our strategy, future operations, future financial position, future revenues, projected costs,\plain\cf1\f51\fs20\i\qj prospects and plans and objectives of management. The words \u8220?anticipates,\u8221? \u8220?believes,\u8221?\plain\cf1\f51\fs20\i\qj \u8220?estimates,\u8221? \u8220?expects,\u8221? \u8220?intends,\u8221? \u8220?may,\u8221? \u8220?plans,\u8221?\plain\cf1\f51\fs20\i\qj \u8220?projects,\u8221? \u8220?will,\u8221? \u8220?would\u8221? and similar expressions are intended to identify\plain\cf1\f51\fs20\i\qj forward-looking statements, although not all forward-looking statements contain these identifying words. We may not actually\plain\cf1\f51\fs20\i\qj achieve the plans, intentions or expectations disclosed in our forward-looking statements and you should not place undue\plain\cf1\f51\fs20\i\qj reliance on our forward-looking statements. Actual results or events could differ materially from the plans, intentions and\plain\cf1\f51\fs20\i\qj expectations disclosed in the forward-looking statements that we make. These forward-looking statements involve risks and\plain\cf1\f51\fs20\i\qj uncertainties that could cause our actual results to differ materially from those in the forward-looking statements, including,\plain\cf1\f51\fs20\i\qj without limitation, the risks set forth in Part II, Item IA, \u8220?Risk Factors\u8221? in this Quarterly Report on Form 10-Q\plain\cf1\f51\fs20\i\qj and in our other filings with the SEC. The forward-looking statements are applicable only as of the date on which they are\plain\cf1\f51\fs20\i\qj made, and we do not assume any obligation to update any forward-looking statements.\par\pard\plain\fi792\cf1\f51\fs20\qj \~{\*\bkmkstart s934BBAB73996571088FE6612A43D5C9}{\*\bkmkend s934BBAB73996571088FE6612A43D5C9}\par\pard\plain\cf1\f51\fs20\b\ql OVERVIEW
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj Chimerix is a biopharmaceutical company dedicated to discovering, developing and commercializing novel, oral antivirals to\plain\cf1\f51\fs20\qj address unmet medical needs. We were founded in 2000 based on the promise of our proprietary lipid conjugate technology to\plain\cf1\f51\fs20\qj unlock the potential of some of the most broad-spectrum antivirals by enhancing their antiviral activity and safety profiles in\plain\cf1\f51\fs20\qj convenient, orally administrated dosing regimens. Based on our proprietary lipid conjugate technology, our lead compound,\plain\cf1\f51\fs20\qj brincidofovir, is in Phase 3 clinical development. In addition, we have an active discovery program focusing on viral targets for\plain\cf1\f51\fs20\qj which limited or no therapies are currently available.
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\b\i\qj Recent Developments
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\i\qj Dosing Initiated in Phase 3 SUSTAIN and SURPASS Trials of Brincidofovir for Prevention of Cytomegalovirus Disease in Kidney\plain\cf1\f51\fs20\i\qj Transplant Recipients
\par\pard\plain\fs16\par\pard\plain\li396\cf1\f51\fs20\qj In October 2015, we initiated dosing in the Phase 3 kidney transplant program. The SUSTAIN and SURPASS trials are\plain\li396\cf1\f51\fs20\qj evaluating brincidofovir for the prevention of cytomegalovirus (CMV) disease in kidney transplant recipients.
\par\pard\plain\fs16\par\pard\plain\li396\cf1\f51\fs20\b\qj SUSTAIN\plain\li396\cf1\f51\fs20\qj is designed to demonstrate the safety and efficacy of brincidofovir for the prevention of CMV disease in kidney\plain\li396\cf1\f51\fs20\qj transplant recipients at high risk of CMV disease. It is a blinded, non-inferiority study of brincidofovir versus valganciclovir\plain\li396\cf1\f51\fs20\qj in kidney transplant recipients who have not been previously infected with CMV (CMV seronegative recipient, or\plain\li396\cf1\f51\fs20\qj \u8220?R-\u8220?) and who have no immunity to CMV. These CMV seronegative patients who receive a kidney from a\plain\li396\cf1\f51\fs20\qj CMV seropositive ("D+") donor are at high risk of CMV infection and disease.\~ The trial is expected to enroll approximately\plain\li396\cf1\f51\fs20\qj 750 patients with 1:1 randomization to brincidofovir or valganciclovir for 200 days following the transplant.
\par\pard\plain\fs16\par\pard\plain\li396\cf1\f51\fs20\b\qj SURPASS\plain\li396\cf1\f51\fs20\qj is a blinded study of brincidofovir versus valganciclovir in kidney transplant recipients who are CMV seropositive\plain\li396\cf1\f51\fs20\qj ("R+").\~ These CMV seropositive patients are at an increased risk of CMV disease. The trial is expected to enroll\plain\li396\cf1\f51\fs20\qj approximately 520 patients with 1:1 randomization to brincidofovir or valganciclovir for 100 days following the transplant.\par\pard\plain\li396\fi792\cf1\f51\fs20\qj \~\~\~\~\par\pard\plain\li396\cf1\f51\fs20\qj The primary endpoint of both studies is CMV disease, with secondary endpoints related to renal function, a measurement\plain\li396\cf1\f51\fs20\qj closely correlated with long-term kidney graft survival. The same dose of brincidofovir that was studied in the SUPPRESS\plain\li396\cf1\f51\fs20\qj trial in HCT recipients, 100 mg twice-weekly, will be studied in the SUSTAIN and SURPASS trials.
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\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\i\ql BARDA Contract Extension of $13 Million for the Continued Development of Brincidofovir for Smallpox
\par\pard\plain\fs16\par\pard\plain\li396\cf1\f51\fs20\qj In September 2015, we executed an extension of our contract with the Biomedical Advanced Research and Development\plain\li396\cf1\f51\fs20\qj Authority (BARDA) for the development of brincidofovir as a medical countermeasure to treat smallpox. This latest contract\plain\li396\cf1\f51\fs20\qj extension provides approximately $13 million in additional funding. We initiated the development contract with BARDA in\plain\li396\cf1\f51\fs20\qj February 2011 to support early research and development of brincidofovir in animal models of smallpox.
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\i\ql Completed Enrollment of Brincidofovir AdVise Trial for the Treatment of Adenovirus Infection
\par\pard\plain\fs16\par\pard\plain\li396\cf1\f51\fs20\qj In August 2015, we completed enrollment of the AdVise trial, which is evaluating brincidofovir for the treatment of\plain\li396\cf1\f51\fs20\qj adenovirus (AdV) infections in pediatric and adult patients. The AdVise trial enrolled over 200 patients with serious\plain\li396\cf1\f51\fs20\qj adenovirus infections, including patients in the key population of HCT recipients with disseminated AdV disease, a\plain\li396\cf1\f51\fs20\qj life-threatening infection that has reported mortality of up to 80%. HCT recipients with localized or asymptomatic AdV\plain\li396\cf1\f51\fs20\qj infection were also enrolled in AdVise, as were patients with other reasons for immune suppression that had confirmed\plain\li396\cf1\f51\fs20\qj serious adenovirus infections, a group that included solid organ transplant recipients and patients receiving chemotherapy. All\plain\li396\cf1\f51\fs20\qj patients enrolled in AdVise receive brincidofovir orally twice-weekly for 12 weeks, and are followed up to 24 weeks after\plain\li396\cf1\f51\fs20\qj treatment, with a primary endpoint of overall survival. We are also conducting Study 305 to obtain clinical outcomes data in\plain\li396\cf1\f51\fs20\qj patients considered matched controls from the same medical centers as AdVise participants. As our initial NDA submission\plain\li396\cf1\f51\fs20\qj will be CMV only, we now plan to conduct the adenovirus analysis at study conclusion, when all subjects have completed\plain\li396\cf1\f51\fs20\qj 24 weeks of follow-up after dosing with brincidofovir. We\~will continue to prepare data from the AdVise trial and the\plain\li396\cf1\f51\fs20\qj historical matched controls to review with the\~FDA\~to determine the regulatory pathway for the treatment of adenovirus.\plain\li396\cf1\f51\fs20\qj Release of final results of the AdVise trial with matching controls is planned for the second half of 2016.
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\i\ql Brincidofovir Demonstrated a Statistically Significant Survival Benefit in a Pivotal Study in an Animal Model of Smallpox\plain\cf1\f51\fs20\i\ql Infection
\par\pard\plain\fs16\par\pard\plain\li396\cf1\f51\fs20\qj In July 2015, we reported positive results from the pivotal smallpox study that was conducted under the FDA\u8217?s\plain\li396\cf1\f51\fs20\qj Animal Efficacy Rule, which allows for testing of investigational drugs in animal models to support effectiveness in diseases\plain\li396\cf1\f51\fs20\qj which are not ethical or feasible to study in humans. In this well-characterized model of smallpox, animals were\plain\li396\cf1\f51\fs20\qj administered a lethal inoculum of rabbitpox virus, and monitored for clinical signs of disease. Following the onset of the first\plain\li396\cf1\f51\fs20\qj clinical sign of disease, animals were randomized to receive placebo, immediate brincidofovir, or brincidofovir after a delay\plain\li396\cf1\f51\fs20\qj of 24, 48, or 72 hours. The study met its primary endpoint of survival benefit with 100% of the animals that received\plain\li396\cf1\f51\fs20\qj brincidofovir immediately following the confirmation of their first clinical sign of infection surviving the disease. Further,\plain\li396\cf1\f51\fs20\qj animals treated with brincidofovir 24 or 48 hours following the first clinical sign of disease also demonstrated a statistically\plain\li396\cf1\f51\fs20\qj significant (p<0.05) reduction in mortality compared to animals that received placebo.
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\i\ql Procurement of Brincidofovir for the Centers for Disease Control/Strategic National Stockpile
\par\pard\plain\fs16\par\pard\plain\li396\cf1\f51\fs20\qj In April 2015, the Department of Health and Human Services, Office of the Assistant Secretary for Preparedness and\plain\li396\cf1\f51\fs20\qj Response, BARDA posted a notice of intent to use other than full and open competition (Notice of Intent) to award a sole\plain\li396\cf1\f51\fs20\qj source contract to us for the procurement of brincidofovir for the treatment of smallpox.\~ In July 2015, BARDA issued a\plain\li396\cf1\f51\fs20\qj related request for proposal (RFP) to us entitled \u8220?2015 Procurement of a Second Smallpox Antiviral Drug for the\plain\li396\cf1\f51\fs20\qj Strategic National Stockpile."
\par\pard\plain\fs16\par\pard\plain\li396\cf1\f51\fs20\qj In August 2015, we submitted a response to the RFP and we subsequently engaged in discussions with BARDA regarding\plain\li396\cf1\f51\fs20\qj our response. We understand that BARDA had intended to make a contract award on or prior to September 30, 2015, the\plain\li396\cf1\f51\fs20\qj end of the U.S. government's fiscal year, but the contract award was postponed due to a delay in Congressional approval for\plain\li396\cf1\f51\fs20\qj the necessary appropriations.\~ We intend to resume our discussions with BARDA and seek to promptly finalize the contract\plain\li396\cf1\f51\fs20\qj award once the requisite budgetary funding has been approved. We are optimistic that we will be able to enter into a contract\plain\li396\cf1\f51\fs20\qj with BARDA once BARDA is able to secure the requisite budgetary funding, but we cannot guarantee that the necessary\plain\li396\cf1\f51\fs20\qj funding will be approved or made available, or if so, that we will be able to finalize a contract with BARDA on acceptable\plain\li396\cf1\f51\fs20\qj terms.
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\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\b\ql FINANCIAL OVERVIEW\par\pard\plain\fi792\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\i\ql Revenues
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj To date, we have not generated any revenue from product sales. All of our revenue to date has been derived from government\plain\cf1\f51\fs20\qj grants and contracts and the receipt of up-front proceeds under collaboration and license agreements.\par\pard\plain\fi792\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\qj In February 2011, we entered into a contract with BARDA, a U.S. governmental agency that supports the advanced research and\plain\cf1\f51\fs20\qj development, manufacturing, acquisition, and stockpiling of medical countermeasures. The contract originally consisted of an\plain\cf1\f51\fs20\qj initial performance period, referred to as the base performance segment, which ended on May 31, 2013, plus up to four extension\plain\cf1\f51\fs20\qj periods, referred to as option segments. Subsequent option segments to the contract are not subject to automatic renewal and are\plain\cf1\f51\fs20\qj not exercisable at our discretion. The contract is a cost plus fixed fee development contract. Under the contract as currently in\plain\cf1\f51\fs20\qj effect, we may cumulatively receive up to $75.8 million in expense reimbursement and $5.3 million in fees if all remaining\plain\cf1\f51\fs20\qj option segments are exercised. As of September\~30, 2015, we had recognized revenue in aggregate of $42.8 million with respect\plain\cf1\f51\fs20\qj to the base performance segment and the first three extension periods.
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj During the third quarter of 2015, we were performing under the second and third option segments of the BARDA contract during\plain\cf1\f51\fs20\qj which we may receive expense and fee reimbursement up to $17 million under the second option segment and up to $13 million\plain\cf1\f51\fs20\qj under the third option segment. The first option segment ended on April 30, 2015, the second option segment is scheduled to end\plain\cf1\f51\fs20\qj on June 30, 2016 and the third segment is scheduled to end on October 31, 2016. Under the BARDA contract, we recognized\plain\cf1\f51\fs20\qj revenue of $2.3 million and $1.2 million for the three months ended September\~30, 2015 and 2014, respectively, and we\plain\cf1\f51\fs20\qj recognized revenue of $6.1 million and $2.9 million for the nine months ended September\~30, 2015 and 2014, respectively.
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj In December 2014, we entered into a collaboration and licensing agreement with ContraVir Pharmaceuticals (NASDAQ: CTRV)\plain\cf1\f51\fs20\qj for the development and commercialization of CMX157 for certain antiviral indications. In exchange for the license to CMX157\plain\cf1\f51\fs20\qj rights, we received an upfront payment consisting of 120,000 shares of ContraVir Series B Convertible Preferred Stock with a\plain\cf1\f51\fs20\qj stated value of $1.2 million. In addition, we are eligible to receive clinical, regulatory and initial commercial milestones in the\plain\cf1\f51\fs20\qj United States and Europe, as well as royalties and additional milestones based on commercial sales in those territories. We\plain\cf1\f51\fs20\qj recognized the upfront license fee payment from ContraVir as deferred revenue for the year ended December 31, 2014, as our\plain\cf1\f51\fs20\qj performance obligations were not completed as of December 31, 2014. During the second quarter of 2015, the performance\plain\cf1\f51\fs20\qj obligations were completed and we recognized $1.5 million of collaboration and licensing revenue.\par\pard\plain\fi792\cf1\f51\fs20\qj \~\par\pard\plain\cf1\f51\fs20\qj In the future, we may generate revenue from a combination of product sales, license fees, milestone payments and royalties from\plain\cf1\f51\fs20\qj the sales of products developed under licenses of our intellectual property. We expect that any revenue we generate will fluctuate\plain\cf1\f51\fs20\qj from quarter to quarter as a result of the timing and amount of license fees, milestone and other payments, and the amount and\plain\cf1\f51\fs20\qj timing of payments that we receive upon the sale of our products, to the extent any are successfully commercialized. If we fail to\plain\cf1\f51\fs20\qj complete the development of our product candidates in a timely manner or obtain regulatory approval for them, our ability to\plain\cf1\f51\fs20\qj generate future revenue, and our results of operations and financial position, would be materially adversely affected.\par\pard\plain\fi792\cf1\f51\fs20\qj \~\par\pard\plain\cf1\f51\fs20\b\i\qj Research and Development Expenses
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj Since our inception, we have focused our resources on our research and development activities, including conducting preclinical\plain\cf1\f51\fs20\qj studies and clinical trials, manufacturing development efforts and activities related to regulatory filings for our product candidates.\plain\cf1\f51\fs20\qj We recognize research and development expenses as they are incurred. Costs for certain development activities are recognized\plain\cf1\f51\fs20\qj based on an evaluation of the progress to completion of specific tasks using information and data provided to us by our vendors.\plain\cf1\f51\fs20\qj We cannot determine with certainty the duration and completion costs of the current or future clinical studies of our product\plain\cf1\f51\fs20\qj candidates. Our research and development expenses consist primarily of:\par\pard\plain\fi792\cf1\f51\fs20\qj \~
\par\pard\plain
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\pard\plain\intbl\li484\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj salaries and related overhead expenses, which include stock option and employee stock purchase program\plain\intbl\cf1\f51\fs20\qj compensation and benefits, for personnel in research and development functions;\cell{
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\pard\plain\intbl\li484\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj payments to third-party manufacturers, which produce, test and package our drug substance and drug product\plain\intbl\cf1\f51\fs20\qj (including continued testing of process validation and stability);\cell{
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\pard\plain\intbl\li484\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj license fees for and milestone payments related to licensed products and\plain\intbl\cf1\f51\fs20\qj technologies.\cell{
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\par\pard\plain\fs16\pard\plain\cf1\f51\fs20\qj We plan to increase our research and development expenses for the foreseeable future as we continue to:
\par\pard\plain\fs16
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\pard\plain\intbl\li484\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj develop brincidofovir for the prevention of CMV infection in HCT\plain\intbl\cf1\f51\fs20\qj recipients;\cell{
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\pard\plain\intbl\li484\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj develop brincidofovir for the treatment of AdV infections, for the prevention of CMV in kidney transplant recipients,\plain\intbl\cf1\f51\fs20\qj and for other indications;\cell{
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\pard\plain\intbl\li484\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj advance the development of our other product candidates, subject to the availability of additional funding; and\cell{
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\pard\plain\intbl\li484\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj expand operations in\plain\intbl\cf1\f51\fs20\qj Europe.\cell{
{\trowd\cellx689\cellx2617\trrh495\row}}}\pard\plain\fi792\cf1\f51\fs20\qj \~\par\pard\plain\cf1\f51\fs20\qj The table below summarizes our research and development expenses for the periods indicated (in thousands). Our direct research\plain\cf1\f51\fs20\qj and development expenses consist primarily of external costs, such as fees paid to investigators, consultants, central laboratories\plain\cf1\f51\fs20\qj and CROs, in connection with our clinical trials, preclinical development, and payments to third-party manufacturers of drug\plain\cf1\f51\fs20\qj substance and drug product. We typically use our employee and infrastructure resources across multiple research and development\plain\cf1\f51\fs20\qj programs.\par\pard\plain\fi792\cf1\f51\fs20\qj \~
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\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql Indirect research and development expenses\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 1,121\cell
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\pard\plain\intbl\li330\ri22\sb22\sa22\cf1\f51\fs20\ql Total research and development expenses\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\ql $\cell\pard\plain\intbl\sb22\sa22\cf1\f51\fs20\qr 26,406\cell
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\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\ql $\cell\pard\plain\intbl\sb22\sa22\cf1\f51\fs20\qr 65,611\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\ql $\cell\pard\plain\intbl\sb22\sa22\cf1\f51\fs20\qr 29,712\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell{
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\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj The majority of our research and development resources are currently focused on our Phase 3 trial of brincidofovir for prevention\plain\cf1\f51\fs20\qj of CMV in HCT recipients (SUPPRESS), our clinical trial of brincidofovir as a treatment for AdV (AdVise), our Phase 3 trials\plain\cf1\f51\fs20\qj of brincidofovir for prevention of CMV in kidney transplant recipients (SUSTAIN and SURPASS), other planned clinical and\plain\cf1\f51\fs20\qj preclinical studies and other work needed to provide sufficient data supporting the safety, tolerability and efficacy of\plain\cf1\f51\fs20\qj brincidofovir for approval in the United States and equivalent health authority approval outside the United States. We have\plain\cf1\f51\fs20\qj incurred and expect to continue to incur significant expense in connection with these efforts, including expenses related to:\par\pard\plain\fi880\cf1\f51\fs20\qj \~
\par\pard\plain
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj manufacturing to produce, test and package our drug substance and drug product for\plain\intbl\cf1\f51\fs20\qj brincidofovir;\cell{
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\pard\plain
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj initiation, enrollment, and conduct of\plain\intbl\cf1\f51\fs20\qj SUPPRESS;\cell{
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\par\pard\plain\fs16\pard\plain\cf1\f51\fs20\qj In addition, pursuant to our contract with BARDA, we are evaluating brincidofovir for the treatment of smallpox. During the base\plain\cf1\f51\fs20\qj performance segment of the contract, we incurred significant expense in connection with the development of orthopox virus\plain\cf1\f51\fs20\qj animal models, the demonstration of efficacy and pharmacokinetics of brincidofovir in animal models, the conduct of an open\plain\cf1\f51\fs20\qj label clinical safety study for subjects with DNA viral infections, and the manufacture and process validation of bulk drug\plain\cf1\f51\fs20\qj substance and brincidofovir 100 mg tablets. During the first option segment of the contract, we performed additional animal\plain\cf1\f51\fs20\qj testing of brincidofovir. We are currently performing under the second and third option segments of the contract with BARDA\plain\cf1\f51\fs20\qj and have performed additional animal testing of brincidofovir. Further animal studies of brincidofovir may be required in order to\plain\cf1\f51\fs20\qj provide sufficient data supporting the efficacy of brincidofovir for approval in the U.S. and equivalent health authorities outside\plain\cf1\f51\fs20\qj the U.S. for the treatment of smallpox.
\par\pard\plain\fs16
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qc 19
\par\pard\plain\fs16\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par
\page
\par\pard\plain\fs16
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\b\i\qj General and Administrative Expenses
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj General and administrative expenses consist primarily of salaries and related costs for employees in executive, finance,\plain\cf1\f51\fs20\qj commercial, investor relations, information technology, legal, human resources and administrative support functions, including\plain\cf1\f51\fs20\qj share-based compensation expenses and benefits. Other significant general and administrative expenses include the pre-launch\plain\cf1\f51\fs20\qj activities for brincidofovir, accounting and legal services, cost of various consultants, director and officer liability insurance,\plain\cf1\f51\fs20\qj occupancy costs and information systems.\par\pard\plain\fi792\cf1\f51\fs20\qj \~\par\pard\plain\cf1\f51\fs20\qj We expect that our general and administrative expenses will continue to increase due to the potential commercialization of our\plain\cf1\f51\fs20\qj product candidates. We believe that these increases will likely include increased costs for director and officer liability insurance,\plain\cf1\f51\fs20\qj costs related to the hiring of additional personnel,increased fees for outside consultants, lawyers and accountants, and costs of\plain\cf1\f51\fs20\qj building a commercial infrastructure should we elect to do so.\par\pard\plain\fi792\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\i\qj Interest Income (Expense), Net
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj Interest income consists of interest earned on our cash, cash equivalents, short-term investments and long-term investments.\plain\cf1\f51\fs20\qj Interest expense consists primarily of interest accrued or paid on amounts outstanding under our Loan and Security Agreement\plain\cf1\f51\fs20\qj (LSA) with Silicon Valley Bank (SVB) and MidCap Financial SBIC, LP (MidCap). As of October 14, 2015, the LSA was paid\plain\cf1\f51\fs20\qj in full and no amounts remain outstanding.\par\pard\plain\fi792\cf1\f51\fs20\qj \~\par\pard\plain\cf1\f51\fs20\b\i\qj Share-based Compensation\plain\cf1\f51\fs20\qj \~
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj The Financial Accounting Standards Board authoritative guidance\~requires that share-based payment transactions with employees\plain\cf1\f51\fs20\qj be recognized in the financial statements based on their fair value and recognized as compensation expense over the vesting\plain\cf1\f51\fs20\qj period.\~Total share-based compensation expense of $3.7 million and $1.4 million was recognized in the three months ended\plain\cf1\f51\fs20\qj September\~30, 2015 and 2014, respectively, and $8.9 million and $2.8 million was recognized in the nine months ended\plain\cf1\f51\fs20\qj September\~30, 2015 and 2014, respectively. The share-based compensation expense recognized included expense from stock\plain\cf1\f51\fs20\qj options and our 2013 employee stock purchase plan (ESPP).\par\pard\plain\fi792\cf1\f51\fs20\qj \~\par\pard\plain\cf1\f51\fs20\qj We estimate the fair value of our share-based awards to employees and directors using the Black-Scholes pricing model. This\plain\cf1\f51\fs20\qj estimate is affected by our stock price as well as assumptions including the expected volatility, expected term, risk-free interest\plain\cf1\f51\fs20\qj rate, expected dividend yield, expected rate of forfeiture and the fair value of the underlying common stock on the date of grant.\par\pard\plain\fi792\cf1\f51\fs20\qj \~\par\pard\plain\fi792\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\qj CRITICAL ACCOUNTING POLICIES AND SIGNIFICANT JUDGEMENTS AND ESTIMATES\par\pard\plain\fi792\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\qj The preparation of our unaudited consolidated condensed financial statements requires us to make estimates and assumptions that\plain\cf1\f51\fs20\qj affect the reported amounts of assets and liabilities, disclosure of contingent assets and liabilities, and the revenues and expenses\plain\cf1\f51\fs20\qj incurred during the reported periods. We base our estimates on historical experience and on various other factors that we believe\plain\cf1\f51\fs20\qj are reasonable under the circumstances, the results of which form the basis for making judgments about the carrying value of\plain\cf1\f51\fs20\qj assets and liabilities that are not apparent from other sources. Actual results may differ materially from these estimates under\plain\cf1\f51\fs20\qj different assumptions or conditions. We discussed accounting policies and assumptions that involve a higher degree of judgment\plain\cf1\f51\fs20\qj and complexity in Note 1 to our consolidated financial statements in our Annual Report on Form 10-K for the year ended\plain\cf1\f51\fs20\qj December\~31, 2014 filed with the SEC on March 6, 2015, as amended. There have been no material changes during the nine\plain\cf1\f51\fs20\qj months ended September\~30, 2015 to our critical accounting policies, significant judgments and estimates disclosed in our Annual\plain\cf1\f51\fs20\qj Report on Form 10-K for the year ended December\~31, 2014, as amended.\par\pard\plain\fi792\cf1\f51\fs20\ql \~
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qc 20
\par\pard\plain\fs16\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par
\page{\*\bkmkstart s371ACBB551E3F1CFC7E4661295EF02C}{\*\bkmkend s371ACBB551E3F1CFC7E4661295EF02C}
\par\pard\plain\fs16
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\b\ql RESULTS OF OPERATIONS\par\pard\plain\fi792\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\i\ql Comparison of the Three Months Ended September\~30, 2015 and 2014
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj The following table summarizes our results of operations for the three months ended September\~30, 2015 and 2014, together with\plain\cf1\f51\fs20\qj the changes in those items (in thousands, except percentages):\~\par\pard\plain\fi792\cf1\f51\fs20\qj \~
\par\pard\plain
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\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\cf1\f51\fs20\b\qc Three Months Ended September\plain\intbl\li22\sa22\cf1\f51\fs20\b\qc 30,\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\b\qc Dollar\~Change\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\b\qc %\~Change\cell{
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{\trowd\clvertalb\cellx3954\clvertalb\cellx4053\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\clvertalb\cellx5438\clvertalb\cellx5582\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\clvertalb\cellx6967\clvertalb\cellx7066\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10795\trrh298
\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\b\qc 2015\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\b\qc 2014\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\b\qc Increase/(Decrease)\cell{
{\trowd\clvertalb\cellx3954\clvertalb\cellx4053\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\clvertalb\cellx5438\clvertalb\cellx5582\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\clvertalb\cellx6967\clvertalb\cellx7066\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10795\trrh298\row}}}
{\trowd\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx3954\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx4053\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx5294\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx5438\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx5582\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx6823\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx6967\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7066\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx8646\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9069\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9168\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10330\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10792\trrh281
\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\b\ql Revenues:\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr \~\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr \~\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr \~\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr \~\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx3954\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx4053\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx5294\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx5438\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx5582\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx6823\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx6967\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7066\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx8646\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9069\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9168\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10330\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10792\trrh281\row}}}
{\trowd\clvertalb\cellx3954\clvertalb\cellx4053\clvertalb\cellx4222\clvertalb\cellx5293\clvertalb\cellx5437\clvertalb\cellx5581\clvertalb\cellx5750\clvertalb\cellx6821\clvertalb\cellx6965\clvertalb\cellx7064\clvertalb\cellx7487\clvertalb\cellx8644\clvertalb\cellx9067\clvertalb\cellx9166\clvertalb\cellx10328\clvertalb\cellx10790\trrh281
\pard\plain\intbl\li330\ri22\sb22\sa22\cf1\f51\fs20\ql Contract revenue\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\ql $\cell\pard\plain\intbl\sb22\sa22\cf1\f51\fs20\qr 2,271\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\ql $\cell\pard\plain\intbl\sb22\sa22\cf1\f51\fs20\qr 1,185\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\ql $\cell\pard\plain\intbl\sb22\sa22\cf1\f51\fs20\qr 1,086\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 91.6\cell\pard\plain\intbl\ri22\sb22\sa22\cf1\f51\fs20\ql %\cell{
{\trowd\clvertalb\cellx3954\clvertalb\cellx4053\clvertalb\cellx4222\clvertalb\cellx5293\clvertalb\cellx5437\clvertalb\cellx5581\clvertalb\cellx5750\clvertalb\cellx6821\clvertalb\cellx6965\clvertalb\cellx7064\clvertalb\cellx7487\clvertalb\cellx8644\clvertalb\cellx9067\clvertalb\cellx9166\clvertalb\cellx10328\clvertalb\cellx10790\trrh281\row}}}
{\trowd\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx3954\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx4053\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx5294\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx5438\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx5582\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx6823\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx6967\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7066\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx8646\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9069\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9168\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10330\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10792\trrh281
\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\~\~\~\~Collaboration and licensing revenue\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr \u8212?\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr \u8212?\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr \u8212?\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr \u8212?\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx3954\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx4053\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx5294\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx5438\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx5582\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx6823\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx6967\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7066\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx8646\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9069\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9168\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10330\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10792\trrh281\row}}}
{\trowd\clvertalb\cellx3954\clvertalb\cellx4053\clvertalb\cellx5294\clvertalb\cellx5438\clvertalb\cellx5582\clvertalb\cellx6823\clvertalb\cellx6967\clvertalb\cellx7066\clbrdrt\brdrs\brdrcf1\clvertalb\cellx8646\clbrdrt\brdrs\brdrcf1\clvertalb\cellx9069\clvertalb\cellx9168\clvertalb\cellx10330\clvertalb\cellx10792\trrh298
\pard\plain\intbl\li594\ri22\sb22\sa22\cf1\f51\fs20\ql Total revenues\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 2,271\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 1,185\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 1,086\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 91.6\cell\pard\plain\intbl\ri22\sb22\sa22\cf1\f51\fs20\ql %\cell{
{\trowd\clvertalb\cellx3954\clvertalb\cellx4053\clvertalb\cellx5294\clvertalb\cellx5438\clvertalb\cellx5582\clvertalb\cellx6823\clvertalb\cellx6967\clvertalb\cellx7066\clbrdrt\brdrs\brdrcf1\clvertalb\cellx8646\clbrdrt\brdrs\brdrcf1\clvertalb\cellx9069\clvertalb\cellx9168\clvertalb\cellx10330\clvertalb\cellx10792\trrh298\row}}}
{\trowd\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx3954\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx4053\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx5294\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx5438\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx5582\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx6823\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx6967\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7066\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx8646\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9069\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9168\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10330\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10792\trrh281
\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\b\ql Operating expenses:\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr \~\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr \~\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr \~\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr \~\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx3954\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx4053\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx5294\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx5438\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx5582\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx6823\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx6967\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7066\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx8646\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9069\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9168\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10330\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10792\trrh281\row}}}
{\trowd\clvertalb\cellx3954\clvertalb\cellx4053\clvertalb\cellx5294\clvertalb\cellx5438\clvertalb\cellx5582\clvertalb\cellx6823\clvertalb\cellx6967\clvertalb\cellx7066\clvertalb\cellx8646\clvertalb\cellx9069\clvertalb\cellx9168\clvertalb\cellx10330\clvertalb\cellx10792\trrh281
\pard\plain\intbl\li330\ri22\sb22\sa22\cf1\f51\fs20\ql Research and development\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 26,406\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 13,328\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 13,078\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 98.1\cell\pard\plain\intbl\ri22\sb22\sa22\cf1\f51\fs20\ql %\cell{
{\trowd\clvertalb\cellx3954\clvertalb\cellx4053\clvertalb\cellx5294\clvertalb\cellx5438\clvertalb\cellx5582\clvertalb\cellx6823\clvertalb\cellx6967\clvertalb\cellx7066\clvertalb\cellx8646\clvertalb\cellx9069\clvertalb\cellx9168\clvertalb\cellx10330\clvertalb\cellx10792\trrh281\row}}}
{\trowd\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx3954\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx4053\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx5294\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx5438\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx5582\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx6823\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx6967\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7066\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx8646\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9069\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9168\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10330\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10792\trrh281
\pard\plain\intbl\li330\ri22\sb22\sa22\cf1\f51\fs20\ql General and administrative\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 8,613\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 4,717\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 3,896\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 82.6\cell\pard\plain\intbl\ri22\sb22\sa22\cf1\f51\fs20\ql %\cell{
{\trowd\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx3954\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx4053\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx5294\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx5438\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx5582\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx6823\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx6967\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7066\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx8646\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9069\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9168\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10330\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10792\trrh281\row}}}
{\trowd\clvertalb\cellx3954\clvertalb\cellx4053\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\clvertalb\cellx5294\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\clvertalb\cellx5438\clvertalb\cellx5582\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\clvertalb\cellx6823\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\clvertalb\cellx6967\clvertalb\cellx7066\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\clvertalb\cellx8646\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\clvertalb\cellx9069\clvertalb\cellx9168\clvertalb\cellx10330\clvertalb\cellx10792\trrh298
\pard\plain\intbl\li594\ri22\sb22\sa22\cf1\f51\fs20\ql Total operating expenses\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 35,019\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 18,045\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 16,974\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 94.1\cell\pard\plain\intbl\ri22\sb22\sa22\cf1\f51\fs20\ql %\cell{
{\trowd\clvertalb\cellx3954\clvertalb\cellx4053\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\clvertalb\cellx5294\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\clvertalb\cellx5438\clvertalb\cellx5582\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\clvertalb\cellx6823\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\clvertalb\cellx6967\clvertalb\cellx7066\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\clvertalb\cellx8646\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\clvertalb\cellx9069\clvertalb\cellx9168\clvertalb\cellx10330\clvertalb\cellx10792\trrh298\row}}}
{\trowd\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx3954\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx4053\clbrdrt\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx5294\clbrdrt\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx5438\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx5582\clbrdrt\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx6823\clbrdrt\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx6967\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7066\clbrdrt\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx8646\clbrdrt\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9069\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9168\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10330\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10792\trrh298
\pard\plain\intbl\li858\ri22\sb22\sa22\cf1\f51\fs20\ql Loss from operations\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr (32,748\cell\pard\plain\intbl\ri22\sb22\sa22\cf1\f51\fs20\ql )\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr (16,860\cell\pard\plain\intbl\ri22\sb22\sa22\cf1\f51\fs20\ql )\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr (15,888\cell\pard\plain\intbl\ri22\sb22\sa22\cf1\f51\fs20\ql )\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 94.2\cell\pard\plain\intbl\ri22\sb22\sa22\cf1\f51\fs20\ql %\cell{
{\trowd\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx3954\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx4053\clbrdrt\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx5294\clbrdrt\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx5438\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx5582\clbrdrt\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx6823\clbrdrt\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx6967\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7066\clbrdrt\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx8646\clbrdrt\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9069\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9168\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10330\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10792\trrh298\row}}}
{\trowd\clvertalb\cellx3954\clvertalb\cellx4053\clbrdrb\brdrs\brdrcf1\clvertalb\cellx5438\clvertalb\cellx5582\clbrdrb\brdrs\brdrcf1\clvertalb\cellx6967\clvertalb\cellx7066\clbrdrb\brdrs\brdrcf1\clvertalb\cellx9069\clvertalb\cellx9168\clvertalb\cellx10793\trrh281
\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\b\ql Other income (expense):\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell{
{\trowd\clvertalb\cellx3954\clvertalb\cellx4053\clbrdrb\brdrs\brdrcf1\clvertalb\cellx5438\clvertalb\cellx5582\clbrdrb\brdrs\brdrcf1\clvertalb\cellx6967\clvertalb\cellx7066\clbrdrb\brdrs\brdrcf1\clvertalb\cellx9069\clvertalb\cellx9168\clvertalb\cellx10793\trrh281\row}}}
{\trowd\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx3954\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx4053\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx5294\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx5438\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx5582\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx6823\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx6967\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7066\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx8646\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9069\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9168\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10330\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10792\trrh281
\pard\plain\intbl\li330\ri22\sb22\sa22\cf1\f51\fs20\ql Interest income (expense), net\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 299\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr (91\cell\pard\plain\intbl\ri22\sb22\sa22\cf1\f51\fs20\ql )\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 390\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr NM\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell{
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{\trowd\clvertalb\cellx3954\clvertalb\cellx4053\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx4222\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx5293\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx5437\clvertalb\cellx5581\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx5750\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx6821\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx6965\clvertalb\cellx7064\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx7487\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx8644\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx9067\clvertalb\cellx9166\clvertalb\cellx10328\clvertalb\cellx10790\trrh298
\pard\plain\intbl\li858\ri22\sb22\sa22\cf1\f51\fs20\b\ql Net loss\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\ql $\cell\pard\plain\intbl\sb22\sa22\cf1\f51\fs20\qr (32,449\cell\pard\plain\intbl\ri22\sb22\sa22\cf1\f51\fs20\ql )\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\ql $\cell\pard\plain\intbl\sb22\sa22\cf1\f51\fs20\qr (16,951\cell\pard\plain\intbl\ri22\sb22\sa22\cf1\f51\fs20\ql )\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\ql $\cell\pard\plain\intbl\sb22\sa22\cf1\f51\fs20\qr (15,498\cell\pard\plain\intbl\ri22\sb22\sa22\cf1\f51\fs20\ql )\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 91.4\cell\pard\plain\intbl\ri22\sb22\sa22\cf1\f51\fs20\ql %\cell{
{\trowd\clvertalb\cellx3954\clvertalb\cellx4053\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx4222\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx5293\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx5437\clvertalb\cellx5581\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx5750\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx6821\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx6965\clvertalb\cellx7064\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx7487\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx8644\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx9067\clvertalb\cellx9166\clvertalb\cellx10328\clvertalb\cellx10790\trrh298\row}}}
\par\pard\plain\fs16\pard\plain\cf1\f51\fs20\b\i\ql Contract Revenue
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj For the three months ended September\~30, 2015, total contract revenue increased to $2.3 million compared to $1.2 million for the\plain\cf1\f51\fs20\qj three months ended September\~30, 2014. The increase of $1.1 million, or 91.6%, is related to an increase in reimbursable\plain\cf1\f51\fs20\qj expenses related to our contract with BARDA.
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\b\i\ql Research and Development Expenses
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj For the three months ended September\~30, 2015, our research and development expenses increased to $26.4 million compared to\plain\cf1\f51\fs20\qj $13.3 million for the three months ended September\~30, 2014.\~ The increase of $13.1 million, or 98.1%, is primarily related to\plain\cf1\f51\fs20\qj the following:
\par\pard\plain\fs16
\pard\plain
{\trowd\clvertalc\cellx1080\clvertalc\cellx10800\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx1080\clvertalc\cellx10800\trrh-66\row}}}
{\trowd\cellx1080\cellx10800\trrh495
\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj an increase in clinical trial expenses of $9.4 million related to our ongoing Phase 3 SUPPRESS study and our\plain\intbl\cf1\f51\fs20\qj AdVise study, as well as the costs of our Phase 3 SUSTAIN and SURPASS studies;\cell{
{\trowd\cellx1080\cellx10800\trrh495\row}}}
\pard\plain
{\trowd\clvertalc\cellx1080\clvertalc\cellx10800\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx1080\clvertalc\cellx10800\trrh-66\row}}}
{\trowd\cellx1080\cellx10800\trrh742
\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj an increase in compensation and other employee related costs of $3.3 million, consisting of $2.2 million of\plain\intbl\cf1\f51\fs20\qj compensation and benefits expense related to the addition of new employees as we continue to grow our clinical,\plain\intbl\cf1\f51\fs20\qj regulatory, development and manufacturing departments and $1.1 million of share-based compensation; and\cell{
{\trowd\cellx1080\cellx10800\trrh742\row}}}
\pard\plain
{\trowd\clvertalc\cellx1068\clvertalc\cellx10541\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx1068\clvertalc\cellx10541\trrh-66\row}}}
{\trowd\cellx1068\cellx10541\trrh495
\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj an increase of $1.0 million in legal and consulting expenses mainly related to the preparation of regulatory\plain\intbl\cf1\f51\fs20\qj filings.\cell{
{\trowd\cellx1068\cellx10541\trrh495\row}}}
\par\pard\plain\fs16\pard\plain\cf1\f51\fs20\b\i\ql General and Administrative Expenses
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj For the three months ended September\~30, 2015, our general and administrative costs increased to $8.6 million compared to $4.7\plain\cf1\f51\fs20\qj million for the three months ended September\~30, 2014. The increase of $3.9 million, or 82.6%, is primarily related to the\plain\cf1\f51\fs20\qj following:
\par\pard\plain\fs16
\pard\plain
{\trowd\clvertalc\cellx1080\clvertalc\cellx10800\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx1080\clvertalc\cellx10800\trrh-66\row}}}
{\trowd\cellx1080\cellx10800\trrh742
\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\li396\fi-396\cf1\f51\fs20\qj an increase in compensation and other employee related costs of $2.5 million, consisting of an increase of $1.3\plain\intbl\li396\cf1\f51\fs20\qj million of share-based compensation, and $1.2 million of compensation and benefit expense related to the\plain\intbl\li396\cf1\f51\fs20\qj addition of new employees to support commercialization and overall growth of the company;\cell{
{\trowd\cellx1080\cellx10800\trrh742\row}}}
\pard\plain
{\trowd\clvertalc\cellx907\clvertalc\cellx6276\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx907\clvertalc\cellx6276\trrh-66\row}}}
{\trowd\cellx907\cellx6276\trrh495
\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\li396\fi-396\cf1\f51\fs20\qj an increase of $0.5 million in legal, accounting and consulting\plain\intbl\li396\cf1\f51\fs20\qj costs; and\cell{
{\trowd\cellx907\cellx6276\trrh495\row}}}
\pard\plain
{\trowd\clvertalc\cellx1069\clvertalc\cellx10584\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx1069\clvertalc\cellx10584\trrh-66\row}}}
{\trowd\cellx1069\cellx10584\trrh495
\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\li396\fi-396\cf1\f51\fs20\qj an increase in other costs of $0.4 million as we expand our commercialization preparations to launch\plain\intbl\li396\cf1\f51\fs20\qj brincidofovir.\cell{
{\trowd\cellx1069\cellx10584\trrh495\row}}}
\par\pard\plain\fs16
\par\pard\plain\fs16\pard\plain\cf1\f51\fs20\qc 21
\par\pard\plain\fs16\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par
\page
\par\pard\plain\fs16
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\b\i\ql Interest Income (Expense), Net
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj For the three months ended September\~30, 2015, our interest income (expense), net, changed to income of $0.3 million compared\plain\cf1\f51\fs20\qj to an expense of $0.1 million for the three months ended September\~30, 2014. The change of $0.4 million is attributable to\plain\cf1\f51\fs20\qj interest earned on our cash and investments and a decrease in interest expense associated with the smaller outstanding loan\plain\cf1\f51\fs20\qj balance in the third quarter of 2015 compared to the third quarter of 2014 as we continued to pay down the outstanding principal\plain\cf1\f51\fs20\qj balance.\par\pard\plain\fi792\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\i\ql Comparison of the Nine Months Ended September\~30, 2015 and 2014
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj The following table summarizes our results of operations for the nine months ended September\~30, 2015 and 2014, together with\plain\cf1\f51\fs20\qj the changes in those items (in thousands except percentages):\~\par\pard\plain\fi792\cf1\f51\fs20\qj \~
\par\pard\plain
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\pard\plain\intbl\f0\fs16\ql \~\cell{
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\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
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\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\cf1\f51\fs20\b\qc Nine Months Ended September\plain\intbl\li22\sa22\cf1\f51\fs20\b\qc 30,\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\b\qc Dollar\~Change\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\b\qc %\~Change\cell{
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\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\b\qc 2015\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\b\qc 2014\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\b\qc Increase/(Decrease)\cell{
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\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\b\ql Revenues:\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr \~\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr \~\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr \~\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr \~\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell{
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{\trowd\clvertalb\cellx3962\clvertalb\cellx4062\clvertalb\cellx4217\clvertalb\cellx5290\clvertalb\cellx5434\clvertalb\cellx5578\clvertalb\cellx5747\clvertalb\cellx6820\clvertalb\cellx6964\clvertalb\cellx7064\clvertalb\cellx7487\clvertalb\cellx8645\clvertalb\cellx9068\clvertalb\cellx9168\clvertalb\cellx10332\clvertalb\cellx10794\trrh281
\pard\plain\intbl\li330\ri22\sb22\sa22\cf1\f51\fs20\ql Contract revenue\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\ql $\cell\pard\plain\intbl\sb22\sa22\cf1\f51\fs20\qr 6,104\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\ql $\cell\pard\plain\intbl\sb22\sa22\cf1\f51\fs20\qr 2,884\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\ql $\cell\pard\plain\intbl\sb22\sa22\cf1\f51\fs20\qr 3,220\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 111.7\cell\pard\plain\intbl\ri22\sb22\sa22\cf1\f51\fs20\ql %\cell{
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\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\~\~\~\~Collaboration and licensing revenue\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 1,548\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr \u8212?\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 1,548\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr \u8212?\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell{
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{\trowd\clvertalb\cellx3962\clvertalb\cellx4062\clbrdrt\brdrs\brdrcf1\clvertalb\cellx5290\clbrdrt\brdrs\brdrcf1\clvertalb\cellx5434\clvertalb\cellx5578\clbrdrt\brdrs\brdrcf1\clvertalb\cellx6820\clbrdrt\brdrs\brdrcf1\clvertalb\cellx6964\clvertalb\cellx7064\clbrdrt\brdrs\brdrcf1\clvertalb\cellx8645\clbrdrt\brdrs\brdrcf1\clvertalb\cellx9068\clvertalb\cellx9168\clvertalb\cellx10332\clvertalb\cellx10794\trrh298
\pard\plain\intbl\li594\ri22\sb22\sa22\cf1\f51\fs20\ql Total revenues\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 7,652\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 2,884\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 4,768\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 165.3\cell\pard\plain\intbl\ri22\sb22\sa22\cf1\f51\fs20\ql %\cell{
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{\trowd\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx3962\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx4062\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx5435\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx5579\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx6966\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7066\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx8647\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9070\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9170\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10334\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10796\trrh281
\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\b\ql Operating expenses:\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr \~\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr \~\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx3962\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx4062\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx5435\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx5579\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx6966\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7066\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx8647\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9070\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9170\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10334\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10796\trrh281\row}}}
{\trowd\clvertalb\cellx3962\clvertalb\cellx4062\clvertalb\cellx5290\clvertalb\cellx5434\clvertalb\cellx5578\clvertalb\cellx6820\clvertalb\cellx6964\clvertalb\cellx7064\clvertalb\cellx8645\clvertalb\cellx9068\clvertalb\cellx9168\clvertalb\cellx10332\clvertalb\cellx10794\trrh281
\pard\plain\intbl\li330\ri22\sb22\sa22\cf1\f51\fs20\ql Research and development\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 65,611\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 29,712\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 35,899\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 120.8\cell\pard\plain\intbl\ri22\sb22\sa22\cf1\f51\fs20\ql %\cell{
{\trowd\clvertalb\cellx3962\clvertalb\cellx4062\clvertalb\cellx5290\clvertalb\cellx5434\clvertalb\cellx5578\clvertalb\cellx6820\clvertalb\cellx6964\clvertalb\cellx7064\clvertalb\cellx8645\clvertalb\cellx9068\clvertalb\cellx9168\clvertalb\cellx10332\clvertalb\cellx10794\trrh281\row}}}
{\trowd\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx3962\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx4062\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx5290\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx5434\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx5578\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx6820\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx6964\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7064\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx8645\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9068\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9168\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10332\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10794\trrh281
\pard\plain\intbl\li330\ri22\sb22\sa22\cf1\f51\fs20\ql General and administrative\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 22,068\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 11,812\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 10,256\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 86.8\cell\pard\plain\intbl\ri22\sb22\sa22\cf1\f51\fs20\ql %\cell{
{\trowd\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx3962\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx4062\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx5290\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx5434\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx5578\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx6820\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx6964\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7064\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx8645\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9068\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9168\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10332\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10794\trrh281\row}}}
{\trowd\clvertalb\cellx3962\clvertalb\cellx4062\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\clvertalb\cellx5290\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\clvertalb\cellx5434\clvertalb\cellx5578\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\clvertalb\cellx6820\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\clvertalb\cellx6964\clvertalb\cellx7064\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\clvertalb\cellx8645\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\clvertalb\cellx9068\clvertalb\cellx9168\clvertalb\cellx10332\clvertalb\cellx10794\trrh298
\pard\plain\intbl\li594\ri22\sb22\sa22\cf1\f51\fs20\ql Total operating expenses\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 87,679\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 41,524\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 46,155\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 111.2\cell\pard\plain\intbl\ri22\sb22\sa22\cf1\f51\fs20\ql %\cell{
{\trowd\clvertalb\cellx3962\clvertalb\cellx4062\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\clvertalb\cellx5290\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\clvertalb\cellx5434\clvertalb\cellx5578\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\clvertalb\cellx6820\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\clvertalb\cellx6964\clvertalb\cellx7064\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\clvertalb\cellx8645\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\clvertalb\cellx9068\clvertalb\cellx9168\clvertalb\cellx10332\clvertalb\cellx10794\trrh298\row}}}
{\trowd\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx3962\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx4062\clbrdrt\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx5290\clbrdrt\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx5434\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx5578\clbrdrt\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx6820\clbrdrt\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx6964\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7064\clbrdrt\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx8645\clbrdrt\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9068\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9168\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10332\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10794\trrh298
\pard\plain\intbl\li858\ri22\sb22\sa22\cf1\f51\fs20\ql Loss from operations\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr (80,027\cell\pard\plain\intbl\ri22\sb22\sa22\cf1\f51\fs20\ql )\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr (38,640\cell\pard\plain\intbl\ri22\sb22\sa22\cf1\f51\fs20\ql )\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr (41,387\cell\pard\plain\intbl\ri22\sb22\sa22\cf1\f51\fs20\ql )\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 107.1\cell\pard\plain\intbl\ri22\sb22\sa22\cf1\f51\fs20\ql %\cell{
{\trowd\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx3962\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx4062\clbrdrt\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx5290\clbrdrt\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx5434\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx5578\clbrdrt\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx6820\clbrdrt\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx6964\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7064\clbrdrt\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx8645\clbrdrt\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9068\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9168\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10332\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10794\trrh298\row}}}
{\trowd\clvertalb\cellx3962\clvertalb\cellx4062\clbrdrb\brdrs\brdrcf1\clvertalb\cellx5435\clvertalb\cellx5579\clbrdrb\brdrs\brdrcf1\clvertalb\cellx6966\clvertalb\cellx7066\clbrdrb\brdrs\brdrcf1\clvertalb\cellx9071\clvertalb\cellx9171\clvertalb\cellx10798\trrh281
\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\b\ql Other income (expense):\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell{
{\trowd\clvertalb\cellx3962\clvertalb\cellx4062\clbrdrb\brdrs\brdrcf1\clvertalb\cellx5435\clvertalb\cellx5579\clbrdrb\brdrs\brdrcf1\clvertalb\cellx6966\clvertalb\cellx7066\clbrdrb\brdrs\brdrcf1\clvertalb\cellx9071\clvertalb\cellx9171\clvertalb\cellx10798\trrh281\row}}}
{\trowd\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx3962\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx4062\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx5290\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx5434\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx5578\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx6820\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx6964\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7064\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx8645\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9068\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9168\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10332\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10794\trrh281
\pard\plain\intbl\li330\ri22\sb22\sa22\cf1\f51\fs20\ql Interest income (expense), net\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 498\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr (425\cell\pard\plain\intbl\ri22\sb22\sa22\cf1\f51\fs20\ql )\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 923\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr NM\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx3962\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx4062\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx5290\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx5434\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx5578\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx6820\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx6964\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx7064\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx8645\clbrdrb\brdrs\brdrcf1\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9068\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx9168\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10332\clvertalb\clshdng100\clcfpat10\clcbpat10\cellx10794\trrh281\row}}}
{\trowd\clvertalb\cellx3962\clvertalb\cellx4062\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx4217\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx5290\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx5434\clvertalb\cellx5578\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx5747\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx6820\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx6964\clvertalb\cellx7064\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx7487\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx8645\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx9068\clvertalb\cellx9168\clvertalb\cellx10332\clvertalb\cellx10794\trrh298
\pard\plain\intbl\li858\ri22\sb22\sa22\cf1\f51\fs20\b\ql Net loss\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\ql $\cell\pard\plain\intbl\sb22\sa22\cf1\f51\fs20\qr (79,529\cell\pard\plain\intbl\ri22\sb22\sa22\cf1\f51\fs20\ql )\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\ql $\cell\pard\plain\intbl\sb22\sa22\cf1\f51\fs20\qr (39,065\cell\pard\plain\intbl\ri22\sb22\sa22\cf1\f51\fs20\ql )\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\ql $\cell\pard\plain\intbl\sb22\sa22\cf1\f51\fs20\qr (40,464\cell\pard\plain\intbl\ri22\sb22\sa22\cf1\f51\fs20\ql )\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 103.6\cell\pard\plain\intbl\ri22\sb22\sa22\cf1\f51\fs20\ql %\cell{
{\trowd\clvertalb\cellx3962\clvertalb\cellx4062\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx4217\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx5290\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx5434\clvertalb\cellx5578\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx5747\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx6820\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx6964\clvertalb\cellx7064\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx7487\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx8645\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrdb\brdrcf1\clvertalb\cellx9068\clvertalb\cellx9168\clvertalb\cellx10332\clvertalb\cellx10794\trrh298\row}}}
\par\pard\plain\fs16\pard\plain\cf1\f51\fs20\b\i\ql Contract Revenue
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj For the nine months ended September\~30, 2015, total contract revenue increased to $6.1 million compared to $2.9 million for the\plain\cf1\f51\fs20\qj nine months ended September\~30, 2014. The increase of $3.2 million, or 111.7%, is related to an increase in reimbursable\plain\cf1\f51\fs20\qj expenses related to our contract with BARDA.
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\b\i\ql Collaboration and Licensing Revenue
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj For the nine months ended September\~30, 2015, total collaboration and licensing revenue was $1.5 million. In December 2014,\plain\cf1\f51\fs20\qj we entered into a collaboration and licensing agreement with ContraVir Pharmaceuticals. We recognized the upfront license fee\plain\cf1\f51\fs20\qj payment as deferred revenue in 2014. During the second quarter of 2015, we completed our performance obligations related to\plain\cf1\f51\fs20\qj this agreement and recognized $1.5 million of collaboration and licensing revenue.
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\b\i\ql Research and Development Expenses
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj For the nine months ended September\~30, 2015, our research and development expenses increased to $65.6 million compared to\plain\cf1\f51\fs20\qj $29.7 million for the nine months ended September\~30, 2014.\~ The increase of $35.9 million, or 120.8%, is primarily related to\plain\cf1\f51\fs20\qj the following:
\par\pard\plain\fs16
\pard\plain
{\trowd\clvertalc\cellx1080\clvertalc\cellx10800\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx1080\clvertalc\cellx10800\trrh-66\row}}}
{\trowd\cellx1080\cellx10800\trrh495
\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj an increase in clinical trial expenses of $19.7 million related to our ongoing Phase 3 SUPPRESS study and our\plain\intbl\cf1\f51\fs20\qj AdVise study, as well as the costs of our Phase 3 SUSTAIN and SURPASS studies;\cell{
{\trowd\cellx1080\cellx10800\trrh495\row}}}
\pard\plain
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\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj an increase in compensation and other employee related costs of $9.0 million, consisting of $5.6 million of\plain\intbl\cf1\f51\fs20\qj compensation and benefit expense related to the addition of new employees as we continue to grow our clinical,\plain\intbl\cf1\f51\fs20\qj regulatory, development and manufacturing departments and $3.4 million of share-based compensation;\cell{
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj an increase of $4.1 million in drug manufacturing costs for raw materials as we began primary and secondary\plain\intbl\cf1\f51\fs20\qj brincidofovir manufacturing campaigns; and\cell{
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\pard\plain
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj an increase of $2.1 million in legal and consulting expenses mainly related to the preparation of regulatory\plain\intbl\cf1\f51\fs20\qj filings.\cell{
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\par\pard\plain\fs16
\par\pard\plain\fs16\pard\plain\cf1\f51\fs20\qc 22
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\page
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\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\b\i\ql General and Administrative Expenses
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj For the nine months ended September\~30, 2015, our general and administrative costs increased to $22.1 million compared to\plain\cf1\f51\fs20\qj $11.8 million for the nine months ended September\~30, 2014. The increase of $10.3 million, or 86.8%, is primarily related to the\plain\cf1\f51\fs20\qj following:
\par\pard\plain\fs16
\pard\plain
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\li396\fi-396\cf1\f51\fs20\qj an increase in compensation and other employee related costs of $4.6 million, consisting of an increase of $2.7\plain\intbl\li396\cf1\f51\fs20\qj million of share-based compensation and $1.9 million of compensation and benefits related to the addition of\plain\intbl\li396\cf1\f51\fs20\qj new employees to support commercialization and overall growth of the company;\cell{
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\pard\plain
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\li396\fi-396\cf1\f51\fs20\qj an increase in other costs of $3.4 million as we expand our commercialization preparations to launch brincidofovir;\plain\intbl\li396\cf1\f51\fs20\qj and\cell{
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\pard\plain
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\li396\fi-396\cf1\f51\fs20\qj an increase of $1.2 million in legal, accounting and\plain\intbl\li396\cf1\f51\fs20\qj consulting costs.\cell{
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\par\pard\plain\fs16\pard\plain\cf1\f51\fs20\b\i\ql Interest Income (Expense), Net
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj For the nine months ended September\~30, 2015, our interest income (expense), net, changed to income of $0.5 million compared\plain\cf1\f51\fs20\qj to an expense of $0.4 million for the nine months ended September\~30, 2014. The change of $0.9 million is attributable to\plain\cf1\f51\fs20\qj interest earned on our cash and investments and a decrease in interest expense associated with the smaller outstanding loan\plain\cf1\f51\fs20\qj balance in the nine months ended September\~30, 2015 compared to the nine months ended September\~30, 2014 as we continued\plain\cf1\f51\fs20\qj to pay down the outstanding principal balance.
\par\pard\plain\fs16{\*\bkmkstart s940548D7F8F579F2AB846612A4C3295}{\*\bkmkend s940548D7F8F579F2AB846612A4C3295}\par\pard\plain\cf1\f51\fs20\b\ql LIQUIDITY AND CAPITAL RESOURCES\par\pard\plain\fi792\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\qj We have incurred losses since our inception in 2000 and anticipate that we will continue to incur losses for at least the next\plain\cf1\f51\fs20\qj several years. We expect that our research and development and general and administrative expenses will continue to increase\plain\cf1\f51\fs20\qj and, as a result, we will need additional capital to fund our operations, which we may obtain through one or more of equity\plain\cf1\f51\fs20\qj offerings, debt financings, government or other third-party funding, strategic alliances and licensing or collaboration\plain\cf1\f51\fs20\qj arrangements.\par\pard\plain\fi792\cf1\f51\fs20\qj \~\par\pard\plain\cf1\f51\fs20\qj On May 27, 2014, we completed an underwritten public offering of 8,395,000 shares of common stock, including 1,095,000\plain\cf1\f51\fs20\qj shares sold pursuant to the full exercise of an option previously granted to the underwriters to purchase additional shares of\plain\cf1\f51\fs20\qj common stock. All of the shares were offered by us at a price to the public of $14.22 per share. The net proceeds from this\plain\cf1\f51\fs20\qj offering, after deducting underwriting discounts and commissions and other offering expenses payable by us, were approximately\plain\cf1\f51\fs20\qj $111.8 million. The securities described above were offered by us pursuant to a shelf registration statement declared effective by\plain\cf1\f51\fs20\qj the SEC on May 16, 2014. The shelf registration statement allows us to issue shares of our common stock and preferred stock,\plain\cf1\f51\fs20\qj various series of debt securities and warrants to purchase any of such securities, up to a total aggregate offering price of $200\plain\cf1\f51\fs20\qj million from time to time in one or more offerings. As of September\~30, 2015, we had sold approximately $119.4 million of our\plain\cf1\f51\fs20\qj common stock under this shelf registration statement.
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj On November 5, 2014, we completed an underwritten public offering of 4,197,500 shares of common stock, including 547,500\plain\cf1\f51\fs20\qj shares sold pursuant to the full exercise of an option previously granted to the underwriters to purchase additional shares of\plain\cf1\f51\fs20\qj common stock. All of the shares were offered by us at a price to the public of $29.00 per share. The net proceeds from this\plain\cf1\f51\fs20\qj offering, after deducting underwriting discounts and commissions and other offering expenses payable by us, were approximately\plain\cf1\f51\fs20\qj $114 million. The securities described above were offered by us pursuant to an automatic shelf registration statement which\plain\cf1\f51\fs20\qj immediately became effective by rule of the SEC on October 29, 2014. For so long as we continue to satisfy the requirements to\plain\cf1\f51\fs20\qj be deemed a well-known seasoned issuer, this shelf registration statement allows us to issue shares of our common stock up to a\plain\cf1\f51\fs20\qj total aggregate offering price of $150.0 million from time to time in one or more offerings. As of September\~30, 2015, we had\plain\cf1\f51\fs20\qj sold approximately $121.7 million of our common stock under this shelf registration statement.
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj On June 16, 2015, we completed an underwritten public offering of 4,341,250 shares of common stock, including 566,250 shares\plain\cf1\f51\fs20\qj sold pursuant to the full exercise of an option granted to the underwriters to purchase additional shares of common stock. All of\plain\cf1\f51\fs20\qj the shares were offered by us at a price to the public of $39.75 per share. The net proceeds from this offering, after deducting\plain\cf1\f51\fs20\qj underwriting discounts and commissions and other offering expenses payable by us, were approximately $161.9 million. The\plain\cf1\f51\fs20\qj securities described above were offered by us pursuant to a shelf registration statement (including a prospectus) filed with\plain\cf1\f51\fs20\qj the\~SEC on\~June 9, 2015, which became effective by rule of the\~SEC. For so long as we continue to satisfy the requirements to\plain\cf1\f51\fs20\qj be deemed a well-known seasoned issuer, this shelf registration statement allows us to issue shares of our common stock up to a\plain\cf1\f51\fs20\qj total aggregate offering price of $250 million from time to time in one or more offerings. As of September\~30, 2015, we had\plain\cf1\f51\fs20\qj sold approximately $172.6 million of our common stock under this shelf registration statement.
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj We cannot assure you that adequate funding will be available on terms acceptable to us, if at all. Any additional equity\plain\cf1\f51\fs20\qj financings will be dilutive to our stockholders and any additional debt may involve operating covenants that may restrict our\plain\cf1\f51\fs20\qj business. If
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qc 23
\par\pard\plain\fs16\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par
\page
\par\pard\plain\fs16
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj adequate funds are not available through these means, we may be required to curtail significantly one or more of our research or\plain\cf1\f51\fs20\qj development programs, our pre-launch expenses, and any launch and other commercialization expenses for any of our products\plain\cf1\f51\fs20\qj that may receive marketing approval. We cannot assure you that we will successfully develop or commercialize our products\plain\cf1\f51\fs20\qj under development or that our products, if successfully developed, will generate revenues sufficient to enable us to earn a profit.\par\pard\plain\fi792\cf1\f51\fs20\qj \~\par\pard\plain\cf1\f51\fs20\qj As of September\~30, 2015, we had capital available to fund operations of approximately $378.4 million. Cash in excess of\plain\cf1\f51\fs20\qj immediate requirements is invested in accordance with our investment policy, primarily with a view to liquidity and capital\plain\cf1\f51\fs20\qj preservation. We believe that our existing capital available to fund operations will enable us to fund our current operating\plain\cf1\f51\fs20\qj expenses and capital requirements into 2017. Such operating and capital requirements do not contemplate incremental expenses\plain\cf1\f51\fs20\qj associated with a full scale commercial launch of brincidofovir. However, changing circumstances beyond our control may cause\plain\cf1\f51\fs20\qj us to consume capital more rapidly than we currently anticipate.\par\pard\plain\fi792\cf1\f51\fs20\qj \~\par\pard\plain\cf1\f51\fs20\qj During 2012, we entered into a loan and security agreement with SVB and MidCap allowing for borrowing up to $15 million. In\plain\cf1\f51\fs20\qj January 2012, we borrowed $3 million under this agreement which had an interest only period for twelve months, followed by a\plain\cf1\f51\fs20\qj thirty month principal and interest period at a rate of 8.25%. In September 2012, we borrowed an additional $12 million under\plain\cf1\f51\fs20\qj this agreement which had an interest only period of six months, followed with a thirty-two month principal interest period at a\plain\cf1\f51\fs20\qj rate of 8.25%. As of September\~30, 2015, the principal balance of the loan was $0.4 million. As of October 14, 2015, the\plain\cf1\f51\fs20\qj principal balance of the loan was paid in full and no amounts remain outstanding.\par\pard\plain\fi792\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\i\ql Cash Flows
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj The following table sets forth the significant sources and uses of cash for the periods set forth below (in thousands):\par\pard\plain\fi792\cf1\f51\fs20\ql \~
\par\pard\plain
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\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\cf1\f51\fs20\b\qc Nine Months Ended September\plain\intbl\li22\sa22\cf1\f51\fs20\b\qc 30,\cell{
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\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\b\qc 2015\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\b\qc 2014\cell{
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\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql Net cash (used in) provided by:\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr \~\cell
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\pard\plain\intbl\li330\ri22\sb22\sa22\cf1\f51\fs20\ql Investing activities\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr (178,809\cell\pard\plain\intbl\ri22\sb22\sa22\cf1\f51\fs20\ql )\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr (115,572\cell\pard\plain\intbl\ri22\sb22\sa22\cf1\f51\fs20\ql )\cell{
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\pard\plain\intbl\li330\ri22\sb22\sa22\cf1\f51\fs20\ql Financing activities\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 161,858\cell
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 110,150\cell
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\pard\plain\intbl\li594\ri22\sb22\sa22\cf1\f51\fs20\b\ql Net decrease in cash and cash equivalents\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\ql $\cell\pard\plain\intbl\sb22\sa22\cf1\f51\fs20\qr (83,742\cell\pard\plain\intbl\ri22\sb22\sa22\cf1\f51\fs20\ql )\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\ql $\cell\pard\plain\intbl\sb22\sa22\cf1\f51\fs20\qr (35,626\cell\pard\plain\intbl\ri22\sb22\sa22\cf1\f51\fs20\ql )\cell{
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\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj Net cash used in operating activities of $66.8 million for the nine months ended September\~30, 2015 was primarily the result of\plain\cf1\f51\fs20\qj our $79.5 million net loss, partially offset by the add-back of non-cash expenses of $8.9 million for share-based compensation\plain\cf1\f51\fs20\qj and $1.2 million of accretion on investments. The change in operating assets and liabilities includes an increase of $7.9 million in\plain\cf1\f51\fs20\qj accounts payable and accrued liabilities, partially offset by an increase in prepaid expenses and other current assets of $5.4\plain\cf1\f51\fs20\qj million primarily related to activities of our clinical trials and an increase in accounts receivable of $0.4 million related to work\plain\cf1\f51\fs20\qj on the BARDA contract. Net cash used in operating activities of $30.2 million during the nine months ended September\~30, 2014\plain\cf1\f51\fs20\qj was primarily the result of our $39.1 million net loss, partially offset by the add-back of non-cash expenses of $2.8 million for\plain\cf1\f51\fs20\qj share-based compensation and $0.7 million of accretion on investments. The change in operating assets and liabilities includes an\plain\cf1\f51\fs20\qj increase of $6.5 million in accounts payable and accrued liabilities, partially offset by\~an increase in accounts receivable of $0.7\plain\cf1\f51\fs20\qj million related to work on the BARDA contract and an increase in prepaid expenses and other current assets of $0.8 million\plain\cf1\f51\fs20\qj primarily related to activities of our clinical trials.\par\pard\plain\fi792\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\i\ql Investing Activities
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj Net cash used in investing activities of $178.8 million for the nine months ended September\~30, 2015 primarily relates to the\plain\cf1\f51\fs20\qj purchase of $56.3 million in short-term and $212.8 million in long-term investments, partially offset by the maturities of $90.8\plain\cf1\f51\fs20\qj million in short-term investments. Net cash used in investing activities of $115.6 million during the nine months ended\plain\cf1\f51\fs20\qj September\~30, 2014 was primarily the result of the purchase of $138.1 million in short-term investments, partially offset by the\plain\cf1\f51\fs20\qj maturities of $20.7 million in short-term investments.\par\pard\plain\fi792\cf1\f51\fs20\ql \~
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qc 24
\par\pard\plain\fs16\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par
\page
\par\pard\plain\fs16
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\i\ql Financing Activities
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj Net cash provided by financing activities of $161.9 million for the nine months ended September\~30, 2015 was primarily the\plain\cf1\f51\fs20\qj result of approximately $161.9 million in net proceeds from the completion of a public offering and $4.0 million from the\plain\cf1\f51\fs20\qj exercise of warrants, stock options and stock purchases through our ESPP, partially offset by $4.0 million in debt repayment. Net\plain\cf1\f51\fs20\qj cash provided by financing activities of $110.2 million for the nine months ended September\~30, 2014 was primarily the result of\plain\cf1\f51\fs20\qj approximately $111.8 million in net proceeds from the completion of a public offering and $2.6 million in proceeds from the\plain\cf1\f51\fs20\qj exercise of stock options and stock purchases through our ESPP, partially offset by $4.3 million in debt repayment.\par\pard\plain\fi792\cf1\f51\fs20\qj \~{\*\bkmkstart s4A2AEFA3AD8BCE3DD2066612A4E3D10}{\*\bkmkend s4A2AEFA3AD8BCE3DD2066612A4E3D10}\par\pard\plain\cf1\f51\fs20\b\ql CONTRACTUAL OBLIGATIONS AND COMMITMENTS\par\pard\plain\fi792\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\qj There have been no material changes to our contractual obligations and commitments outside the ordinary course of business\plain\cf1\f51\fs20\qj from those disclosed under the heading \u8220?Management\u8217?s Discussion and Analysis of Financial Condition and Results\plain\cf1\f51\fs20\qj of Operations-Contractual Obligations and Commitments\u8221? as contained in our Annual Report on Form 10-K for the year\plain\cf1\f51\fs20\qj ended December\~31, 2014 filed by us with the SEC on March 6, 2015, as amended.\par\pard\plain\fi792\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\i\ql Off-Balance Sheet Arrangements
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj During the periods presented, we did not have, nor do we currently have, any off-balance sheet arrangements as defined under\plain\cf1\f51\fs20\qj SEC rules.
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qc 25
\par\pard\plain\fs16\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par
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\par\pard\plain\fs16{\*\bkmkstart item_1_3_3}{\*\bkmkend item_1_3_3}\par\pard\plain\cf1\f51\fs20\b\ql ITEM 3. \~\~\~\~QUANTITATIVE AND QUALITATIVE DISCLOSURES ABOUT MARKET RISK\par\pard\plain\fi792\cf1\f51\fs20\qj \~\par\pard\plain\cf1\f51\fs20\qj Our primary exposure to market risk is interest income sensitivity, which is affected by changes in the general level of U.S.\plain\cf1\f51\fs20\qj interest rates. Due to the duration of our investment portfolio and the low risk profile of our investments, an immediate 10%\plain\cf1\f51\fs20\qj change in interest rates would not have a material effect on the fair market value of our portfolio. Accordingly, we would not\plain\cf1\f51\fs20\qj expect our operating results or cash flows to be affected to any significant degree by the effect of a sudden change in market\plain\cf1\f51\fs20\qj interest rates on our investment portfolio.\par\pard\plain\fi792\cf1\f51\fs20\qj \~\par\pard\plain\cf1\f51\fs20\qj We do not believe that our cash, cash equivalents and available-for-sale investments have significant risk of default or\plain\cf1\f51\fs20\qj illiquidity. While we believe our cash and cash equivalents and certificates of deposit do not contain excessive risk, we cannot\plain\cf1\f51\fs20\qj provide absolute assurance that in the future our investments will not be subject to adverse changes in market value. In addition,\plain\cf1\f51\fs20\qj we maintain significant amounts of cash and cash equivalents at one or more financial institutions that are in excess of federally\plain\cf1\f51\fs20\qj insured limits.\par\pard\plain\fi792\cf1\f51\fs20\qj \~\par\pard\plain\cf1\f51\fs20\qj Inflation generally affects us by increasing our cost of labor and clinical trial costs. We do not believe that inflation has had a\plain\cf1\f51\fs20\qj material effect on our consolidated results of operations for the three and nine months ending September\~30, 2015 or 2014.\par\pard\plain\fi792\cf1\f51\fs20\ql \~{\*\bkmkstart s554781824217A3DDB9706612A537F00}{\*\bkmkend s554781824217A3DDB9706612A537F00}{\*\bkmkstart item_1_3_4}{\*\bkmkend item_1_3_4}\par\pard\plain\cf1\f51\fs20\b\ql ITEM 4. \~\~\~\~CONTROLS AND PROCEDURES\par\pard\plain\fi792\cf1\f51\fs20\b\ql \~\par\pard\plain\cf1\f51\fs20\b\i\ql Evaluation of Disclosure Controls and Procedures
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj Our principal executive officer and principal financial officer, after evaluating the effectiveness of our disclosure controls and\plain\cf1\f51\fs20\qj procedures (as defined in Rules 13a-15(e) and 15d-15(e) of the Securities Exchange Act of 1934, as amended, or Exchange Act)\plain\cf1\f51\fs20\qj as of September\~30, 2015, have concluded that, based on such evaluation, our disclosure controls and procedures were effective\plain\cf1\f51\fs20\qj to ensure that information required to be disclosed by us in the reports we file or submit under the Exchange Act is recorded,\plain\cf1\f51\fs20\qj processed, summarized and reported, within the time periods specified in the rules and forms of the SEC, and is accumulated and\plain\cf1\f51\fs20\qj communicated to our management, including our principal executive and principal financial officers, or persons performing\plain\cf1\f51\fs20\qj similar functions, as appropriate to allow timely decisions regarding required disclosure.\par\pard\plain\fi792\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\i\ql Changes in Internal Control over Financial Reporting
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj No change in our internal control over financial reporting (as defined in Rules 13a-15(d) and 15d-15(d) under the Exchange\plain\cf1\f51\fs20\qj Act) occurred during the three months ended September\~30, 2015 that has materially affected, or is reasonably likely to materially\plain\cf1\f51\fs20\qj affect, our internal control over financial reporting.\par\pard\plain\fi792\cf1\f51\fs20\ql \~
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qc 26
\par\pard\plain\fs16\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par
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\par\pard\plain\fs16{\*\bkmkstart part_1_2_2}{\*\bkmkend part_1_2_2}\par\pard\plain\cf1\f51\fs20\b\ql PART II - OTHER INFORMATION\par\pard\plain\fi792\cf1\f51\fs20\b\ql \~{\*\bkmkstart s16E760194B6244480DB26612A58B2D7}{\*\bkmkend s16E760194B6244480DB26612A58B2D7}{\*\bkmkstart item_1_3_5}{\*\bkmkend item_1_3_5}\par\pard\plain\cf1\f51\fs20\b\qj ITEM 1. \~\~\~\~LEGAL PROCEEDINGS\par\pard\plain\fi792\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\ql None.\par\pard\plain\fi792\cf1\f51\fs20\ql \~{\*\bkmkstart s9EC4E6764099969EFB9466129624D99}{\*\bkmkend s9EC4E6764099969EFB9466129624D99}{\*\bkmkstart item_1_3_6}{\*\bkmkend item_1_3_6}\par\pard\plain\cf1\f51\fs20\b\ql ITEM\~1A.\~\~\~\~\~\~\~\~RISK FACTORS\par\pard\plain\cf1\f51\fs20\qj \~
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\i\ql An investment in shares of our common stock involves a high degree of risk. You should carefully consider the following risk\plain\cf1\f51\fs20\i\ql factors, as well as the other information contained elsewhere in this report, before deciding whether to purchase, hold or sell\plain\cf1\f51\fs20\i\ql shares of our common stock. The occurrence of any of the following risks could harm our business, financial condition, results of\plain\cf1\f51\fs20\i\ql operations and/or growth prospects or cause our actual results to differ materially from those contained in forward-looking\plain\cf1\f51\fs20\i\ql statements we have made in this report and those we may make from time to time. You should consider all of the risk factors\plain\cf1\f51\fs20\i\ql described when evaluating our business. We have marked with an asterisk (*) those risk factors that reflect changes from the risk\plain\cf1\f51\fs20\i\ql factors included in our Annual Report on Form 10-K for the year ended December 31, 2014 filed with the Securities and\plain\cf1\f51\fs20\i\ql Exchange Commission on March 6, 2015, as amended.\par\pard\plain\fi528\cf1\f51\fs20\b\qc \~\par\pard\plain\cf1\f51\fs20\b\qc Risks Related To Our Financial Condition and Need For Additional Capital\par\pard\plain\cf1\f51\fs20\b\i\qj \~\par\pard\plain\cf1\f51\fs20\b\i\qj We have incurred significant losses since our inception. We anticipate that we will continue to incur significant losses for the\plain\cf1\f51\fs20\b\i\qj foreseeable future, and we may never achieve or maintain profitability.*\par\pard\plain\cf1\f51\fs20\qj \~\par\pard\plain\cf1\f51\fs20\qj We are a biopharmaceutical company focused primarily on developing our lead product candidate, brincidofovir. We have\plain\cf1\f51\fs20\qj incurred significant net losses in each year since our inception, including net losses of $79.5 million and $39.1 million for the\plain\cf1\f51\fs20\qj nine months ended September\~30, 2015 and 2014, respectively. As of September\~30, 2015, we had an accumulated deficit of\plain\cf1\f51\fs20\qj approximately $301.6 million.\par\pard\plain\cf1\f51\fs20\qj \~\par\pard\plain\cf1\f51\fs20\qj To date, we have financed our operations primarily through the sale of equity securities and, to a lesser extent, through\plain\cf1\f51\fs20\qj government funding, licensing fees and debt. We have devoted most of our financial resources to research and development,\plain\cf1\f51\fs20\qj including our preclinical development activities and clinical trials. We have not completed development of any product\plain\cf1\f51\fs20\qj candidates. We expect to continue to incur losses and negative cash flows for the foreseeable future. The size of our losses will\plain\cf1\f51\fs20\qj depend, in part, on the rate of future expenditures and our ability to generate revenues. In particular, we expect to incur\plain\cf1\f51\fs20\qj substantial and increased expenses as we:\par\pard\plain\cf1\f51\fs20\qj \~\~
\par\pard\plain
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj continue the development of our lead product candidate, brincidofovir, for the prevention of cytomegalovirus (CMV)\plain\intbl\cf1\f51\fs20\qj infection in hematopoietic cell transplant (HCT) recipients and solid organ transplant recipients;\cell{
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj continue the development of brincidofovir for the treatment of adenovirus (AdV)\plain\intbl\cf1\f51\fs20\qj infection;\cell{
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj seek to obtain regulatory approvals for\plain\intbl\cf1\f51\fs20\qj brincidofovir;\cell{
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj prepare for the potential commercialization of\plain\intbl\cf1\f51\fs20\qj brincidofovir;\cell{
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj scale-up manufacturing capabilities to commercialize brincidofovir for any indications for which we receive\plain\intbl\cf1\f51\fs20\qj regulatory approval;\cell{
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj begin outsourcing of the commercial manufacturing of brincidofovir for any indications for which we receive\plain\intbl\cf1\f51\fs20\qj regulatory approval;\cell{
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj establish an infrastructure for the sales, marketing and distribution of brincidofovir for any indications for which we\plain\intbl\cf1\f51\fs20\qj receive regulatory approval;\cell{
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj expand our research and development activities and advance our clinical\plain\intbl\cf1\f51\fs20\qj programs;\cell{
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj maintain, expand and protect our intellectual\plain\intbl\cf1\f51\fs20\qj property portfolio;\cell{
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj continue our research and development efforts and seek to discover additional product candidates;\plain\intbl\cf1\f51\fs20\qj and\cell{
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj add operational, financial and management information systems and personnel, including personnel to support our\plain\intbl\cf1\f51\fs20\qj product development and commercialization efforts and operations as a public company.\cell{
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\par\pard\plain\fs16\pard\plain\cf1\f51\fs20\qj To become and remain profitable, we must succeed in developing and eventually commercializing products with significant\plain\cf1\f51\fs20\qj market potential. This will require us to be successful in a range of challenging activities, including discovering product\plain\cf1\f51\fs20\qj candidates, completing preclinical testing and clinical trials of our product candidates, obtaining regulatory approval for these\plain\cf1\f51\fs20\qj product candidates, and manufacturing, marketing and selling those products for which we may obtain regulatory approval. We\plain\cf1\f51\fs20\qj are only in the preliminary stages of some of these activities.\par\pard\plain\cf1\f51\fs20\qj \~
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\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj To date, we have not completed Phase 3 clinical trials or obtained regulatory approval for any of our product candidates, and\plain\cf1\f51\fs20\qj none of our product candidates have been commercialized. We may never succeed in developing or commercializing any of our\plain\cf1\f51\fs20\qj product candidates. If our product candidates are not successfully developed or commercialized, or if revenues from any products\plain\cf1\f51\fs20\qj that do receive regulatory approvals are insufficient, we will not achieve profitability and our business may fail. Even if we\plain\cf1\f51\fs20\qj successfully obtain regulatory approval to market our product candidates in the United States, our revenues are also dependent\plain\cf1\f51\fs20\qj upon the size of markets outside of the United States, as well as our ability to obtain market approval and achieve commercial\plain\cf1\f51\fs20\qj success outside of the United States.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\qj Even if we do achieve profitability, we may not be able to sustain or increase profitability on a quarterly or annual basis. Our\plain\cf1\f51\fs20\qj failure to become and remain profitable would depress the value of our company and could impair our ability to raise capital,\plain\cf1\f51\fs20\qj expand our business, diversify our product offerings or continue our operations. A decline in the value of our company could\plain\cf1\f51\fs20\qj cause you to lose all or part of your investment.\par\pard\plain\cf1\f51\fs20\b\i\qj \~\par\pard\plain\cf1\f51\fs20\b\i\qj Our ability to generate future revenues from product sales is uncertain and depends upon our ability to successfully develop,\plain\cf1\f51\fs20\b\i\qj obtain regulatory approval for, and commercialize our product candidates.*\par\pard\plain\cf1\f51\fs20\qj \~\par\pard\plain\cf1\f51\fs20\qj Our ability to generate revenue and achieve profitability depends on our ability, alone or with collaborators, to successfully\plain\cf1\f51\fs20\qj complete the development, obtain the necessary regulatory approvals and commercialize our product candidates. We do not\plain\cf1\f51\fs20\qj anticipate generating revenues from sales of our product candidates for the foreseeable future. Our ability to generate future\plain\cf1\f51\fs20\qj revenues from product sales depends heavily on our success in:\par\pard\plain\cf1\f51\fs20\ql \~
\par\pard\plain
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\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj obtaining favorable results for and advancing the development of brincidofovir, initially for the prevention of CMV\plain\intbl\cf1\f51\fs20\qj in HCT recipients, including successfully completing Phase 3 clinical development;\cell{
{\trowd\cellx1080\cellx10800\trrh495\row}}}
\pard\plain
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\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj obtaining United States and foreign regulatory approval for brincidofovir, initially for the prevention of CMV\plain\intbl\cf1\f51\fs20\qj infection in HCT recipients;\cell{
{\trowd\cellx1080\cellx10800\trrh495\row}}}
\pard\plain
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj obtaining U.S. and foreign regulatory approvals for brincidofovir for the treatment of AdV\plain\intbl\cf1\f51\fs20\qj infection;\cell{
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\pard\plain
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj launching and commercializing brincidofovir, including establishing a sales force and collaborating with third\plain\intbl\cf1\f51\fs20\qj parties;\cell{
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\pard\plain
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj achieving broad market acceptance of brincidofovir in the medical community and with third-party\plain\intbl\cf1\f51\fs20\qj payers;\cell{
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\pard\plain
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj obtaining traditional approval in the U. S. for brincidofovir for CMV\plain\intbl\cf1\f51\fs20\qj prevention; and\cell{
{\trowd\cellx951\cellx7585\trrh495\row}}}
\pard\plain
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\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj generating, in licensing or otherwise acquiring a pipeline of product candidates which progress to clinical\plain\intbl\cf1\f51\fs20\qj development.\cell{
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\par\pard\plain\fs16\pard\plain\cf1\f51\fs20\qj Conducting preclinical testing and clinical trials is a time-consuming, expensive and uncertain process that takes years to\plain\cf1\f51\fs20\qj complete, and we may never generate the necessary data required to obtain regulatory approval and achieve product sales. Our\plain\cf1\f51\fs20\qj anticipated development costs would likely increase if we do not obtain favorable results or if development of our product\plain\cf1\f51\fs20\qj candidates is delayed. In particular, we would likely incur higher costs than we currently anticipate if development of our product\plain\cf1\f51\fs20\qj candidates is delayed because we are required by the U.S. Food and Drug Administration (FDA) or foreign regulatory authorities\plain\cf1\f51\fs20\qj to perform studies or trials in addition to those that we currently anticipate, or we decide to conduct additional studies or trials\plain\cf1\f51\fs20\qj for strategic reasons. For example, SUSTAIN is intended to fulfill our regulatory need for a second confirmatory study should the\plain\cf1\f51\fs20\qj SUPPRESS data support accelerated approval for the prevention of clinically significant CMV infection, while SURPASS is\plain\cf1\f51\fs20\qj designed primarily to evaluate brincidofovir in a significantly more common setting of kidney transplant patients than that\plain\cf1\f51\fs20\qj provided by the patient population for SUSTAIN. Because of the numerous risks and uncertainties associated with pharmaceutical\plain\cf1\f51\fs20\qj product development, we are unable to predict the timing or amount of any increase in our anticipated development costs.\par\pard\plain\cf1\f51\fs20\qj \~\par\pard\plain\cf1\f51\fs20\qj In addition, our product candidates, if approved, may not achieve commercial success. Our commercial revenues, if any, will be\plain\cf1\f51\fs20\qj derived from sales of products that we do not expect to be commercially available for a number of years, if at all. Even if one or\plain\cf1\f51\fs20\qj more of our product candidates is approved for commercial sale, we anticipate incurring significant costs in connection with\plain\cf1\f51\fs20\qj commercialization. As a result, we cannot assure you that we will be able to generate revenues from sales of any approved\plain\cf1\f51\fs20\qj product candidates, or that we will achieve or maintain profitability even if we do generate sales.\par\pard\plain\cf1\f51\fs20\b\i\qj \~\par\pard\plain\cf1\f51\fs20\b\i\qj If we fail to obtain additional financing, we could be forced to delay, reduce or eliminate our product development programs,\plain\cf1\f51\fs20\b\i\qj seek corporate partners for the development of our product development programs or relinquish or license on unfavorable\plain\cf1\f51\fs20\b\i\qj terms, our rights to technologies or product candidates.*\par\pard\plain\cf1\f51\fs20\qj \~\par\pard\plain\cf1\f51\fs20\qj Developing pharmaceutical products, including conducting preclinical studies and clinical trials, is a time-consuming, expensive\plain\cf1\f51\fs20\qj and uncertain process that takes years to complete. We expect our research and development expenses to increase in connection\plain\cf1\f51\fs20\qj with our ongoing activities, particularly as we advance our clinical programs for brincidofovir.\par\pard\plain\cf1\f51\fs20\qj \~
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\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj We believe that our existing capital available to fund operations will enable us to fund our current operating expenses and capital\plain\cf1\f51\fs20\qj requirements into 2017. Such operating and capital requirements do not contemplate incremental expenses associated with a full\plain\cf1\f51\fs20\qj scale commercial launch of brincidofovir. However, changing circumstances beyond our control may cause us to consume capital\plain\cf1\f51\fs20\qj more rapidly than we currently anticipate. For example, our clinical trials may encounter technical, enrollment or other difficulties\plain\cf1\f51\fs20\qj that could increase our development costs more than we expected, or because the FDA or foreign regulatory authorities requires\plain\cf1\f51\fs20\qj us to perform studies or trials in addition to those that we currently anticipate. We may need to raise additional funds if we\plain\cf1\f51\fs20\qj choose to initiate clinical trials for our product candidates other than brincidofovir. In any event, we will require additional\plain\cf1\f51\fs20\qj capital to commercialize our lead product candidate, brincidofovir.
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj For so long as we continue to satisfy the requirements to be deemed a well-known seasoned issuer, we are permitted to file\plain\cf1\f51\fs20\qj registration statements, which will be automatically effective, and allow us to sell an unlimited amount of securities from\plain\cf1\f51\fs20\qj time-to-time.\par\pard\plain\cf1\f51\fs20\qj \~\par\pard\plain\cf1\f51\fs20\qj Securing additional financing may divert our management from our day-to-day activities, which may adversely affect our ability\plain\cf1\f51\fs20\qj to develop and commercialize our product candidates, including brincidofovir. In addition, we cannot guarantee that future\plain\cf1\f51\fs20\qj financing will be available in sufficient amounts or on terms acceptable to us, if at all. If we are unable to raise additional capital\plain\cf1\f51\fs20\qj when required or on acceptable terms, we may be required to:\par\pard\plain\cf1\f51\fs20\ql \~
\par\pard\plain
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj significantly delay, scale back or discontinue the development or commercialization of our product candidates,\plain\intbl\cf1\f51\fs20\qj including brincidofovir;\cell{
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj seek corporate partners for brincidofovir or any of our other product candidates at an earlier stage than otherwise\plain\intbl\cf1\f51\fs20\qj would be desirable or on terms that are less favorable than might otherwise be available; or\cell{
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\pard\plain
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj relinquish or license on unfavorable terms, our rights to technologies or product candidates that we otherwise would\plain\intbl\cf1\f51\fs20\qj seek to develop or commercialize ourselves.\cell{
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\par\pard\plain\fs16\pard\plain\cf1\f51\fs20\qj If we are unable to raise additional capital in sufficient amounts or on terms acceptable to us, we will be prevented from\plain\cf1\f51\fs20\qj pursuing development and commercialization efforts, which will have a material adverse effect on our business, operating results\plain\cf1\f51\fs20\qj and prospects and on our ability to develop our product candidates.\par\pard\plain\cf1\f51\fs20\qj \~\par\pard\plain\fi528\cf1\f51\fs20\b\qc \~Risks Related To Clinical Development and Regulatory Approval\par\pard\plain\cf1\f51\fs20\b\i\qj \~\par\pard\plain\cf1\f51\fs20\b\i\qj We depend on the success of our lead product candidate, brincidofovir, which is still under clinical development, and may not\plain\cf1\f51\fs20\b\i\qj obtain regulatory approval or be successfully commercialized.*\par\pard\plain\cf1\f51\fs20\qj \~\par\pard\plain\cf1\f51\fs20\qj We have not marketed, distributed or sold any products. The success of our business depends upon our ability to develop and\plain\cf1\f51\fs20\qj commercialize our lead product candidate, brincidofovir, which has completed a Phase 2 clinical trial for the prevention of CMV\plain\cf1\f51\fs20\qj infection in adult HCT recipients and a Phase 2 trial in preemptive treatment of adenovirus infection in adult and pediatric HCT\plain\cf1\f51\fs20\qj recipients.
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj In August 2013, we initiated a Phase 3 trial, known as SUPPRESS, for the prevention of CMV infection in allogeneic HCT\plain\cf1\f51\fs20\qj recipients. In June 2015, we announced the successful enrollment of the targeted 450 patients in SUPPRESS. We intend to use\plain\cf1\f51\fs20\qj this trial as a basis to submit a New Drug Application (NDA) to the FDA under the accelerated approval pathway seeking\plain\cf1\f51\fs20\qj regulatory approval to market brincidofovir in the United States and to file equivalent applications outside the United States. In\plain\cf1\f51\fs20\qj the first quarter of 2014, we initiated a clinical trial of brincidofovir, known as AdVise, for the treatment of AdV infection in\plain\cf1\f51\fs20\qj immunocompromised patients. On August 3, 2015, we announced the successful enrollment of the targeted 200 patients in\plain\cf1\f51\fs20\qj AdVise. We are currently also conducting Study 305 to obtain clinical outcomes data in patients considered matched controls\plain\cf1\f51\fs20\qj from the same medical centers as AdVise participants. We\~will continue to prepare data from the AdVise trial and the historical\plain\cf1\f51\fs20\qj matched controls to review with the\~FDA\~to determine the regulatory pathway for the treatment of adenovirus.
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj We recently announced the initiation of two Phase 3 clinical trials that we are conducting for the prevention of CMV disease in\plain\cf1\f51\fs20\qj kidney transplant recipients. Improvements in immunosuppressive regimens have decreased the rates of organ rejection over the\plain\cf1\f51\fs20\qj past decade. However, there have not been concomitant advances in antiviral therapy to prevent infection caused by CMV. The\plain\cf1\f51\fs20\qj long term survival of kidney transplants has therefore plateaued, with less than half of transplanted kidneys still functioning a\plain\cf1\f51\fs20\qj decade after surgery. SUSTAIN is a Phase 3 study in kidney transplant recipients at high risk of CMV disease. It is a blinded,\plain\cf1\f51\fs20\qj non-inferiority study of brincidofovir versus valganciclovir in kidney transplant recipients who are CMV seronegative (R-) but\plain\cf1\f51\fs20\qj who receive a kidney from a CMV seropositive (D+) donor. The primary endpoint is CMV disease, with secondary endpoints\plain\cf1\f51\fs20\qj related to renal function at one year, a measurement closely correlated with long-term renal graft survival.\~ The trial is expected\plain\cf1\f51\fs20\qj to enroll approximately 750 patients, and, if positive, could serve as a confirmatory study that would support traditional approval\plain\cf1\f51\fs20\qj in the U.S. for the CMV prevention indication. Because the population for SUSTAIN makes up less than 20% of patients who\plain\cf1\f51\fs20\qj are
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\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj receiving a kidney transplant, it is important to also study brincidofovir in the most common setting of kidney transplantation,\plain\cf1\f51\fs20\qj namely in patients who are CMV seropositive (R+) when they receive their new kidney. These patients are at increased risk of\plain\cf1\f51\fs20\qj CMV reactivation due to the significant immunosuppression they receive to avoid organ rejection. CMV seropositive organ\plain\cf1\f51\fs20\qj recipients comprise over half the transplant recipients; patients in this population will be enrolled in the parallel SURPASS trial.\plain\cf1\f51\fs20\qj SURPASS has a similar design to SUSTAIN, and is a blinded study of brincidofovir versus valganciclovir in kidney transplant\plain\cf1\f51\fs20\qj recipients who are CMV seropositive (R+).\~ The primary endpoint is CMV disease, with secondary endpoints related to renal\plain\cf1\f51\fs20\qj function at six months.\~ The trial is expected to enroll approximately 520 patients.
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj SUSTAIN is intended to fulfill our regulatory need for a second confirmatory study for the prevention of CMV infection should\plain\cf1\f51\fs20\qj the SUPPRESS data support an accelerated approval in the United States, while SURPASS is designed primarily to evaluate\plain\cf1\f51\fs20\qj brincidofovir in a significantly more common setting of kidney transplant patients than that provided by the patient population for\plain\cf1\f51\fs20\qj SUSTAIN. We have not conducted a large, dose-ranging study in this patient population. There is no guarantee that our Phase 3\plain\cf1\f51\fs20\qj clinical trials will be completed or, if completed, will be successful, or if successful, will result in an approval. The success of\plain\cf1\f51\fs20\qj brincidofovir will depend on several factors, including the following:\par\pard\plain\cf1\f51\fs20\ql \~
\par\pard\plain
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj successful completion of nonclinical studies and successful enrollment and completion of clinical\plain\intbl\cf1\f51\fs20\qj trials;\cell{
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj receipt of marketing approvals from the FDA and corresponding regulatory authorities outside the United States for\plain\intbl\cf1\f51\fs20\qj our product candidates;\cell{
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj establishing commercial manufacturing\plain\intbl\cf1\f51\fs20\qj capabilities;\cell{
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj launching commercial sales of the product, whether alone or in collaboration with\plain\intbl\cf1\f51\fs20\qj others;\cell{
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\pard\plain
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj acceptance of the product by patients, the medical community and third-party\plain\intbl\cf1\f51\fs20\qj payers;\cell{
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj effectively competing with other\plain\intbl\cf1\f51\fs20\qj therapies;\cell{
{\trowd\cellx787\cellx3564\trrh495\row}}}
\pard\plain
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\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj a continued acceptable safety profile of the product following\plain\intbl\cf1\f51\fs20\qj approval; and\cell{
{\trowd\cellx917\cellx6509\trrh495\row}}}
\pard\plain
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\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj obtaining, maintaining, enforcing and defending intellectual property rights and\plain\intbl\cf1\f51\fs20\qj claims.\cell{
{\trowd\cellx955\cellx7654\trrh495\row}}}
\par\pard\plain\fs16\pard\plain\cf1\f51\fs20\qj If we do not achieve one or more of these factors in a timely manner or at all, we could experience significant delays or an\plain\cf1\f51\fs20\qj inability to successfully commercialize brincidofovir, which would materially harm our business.\par\pard\plain\cf1\f51\fs20\b\i\qj \~\par\pard\plain\cf1\f51\fs20\b\i\qj We have never obtained regulatory approval for a drug and we may be unable to obtain, or may be delayed in obtaining,\plain\cf1\f51\fs20\b\i\qj regulatory approval for brincidofovir.*\par\pard\plain\cf1\f51\fs20\qj \~\par\pard\plain\cf1\f51\fs20\qj We have never obtained regulatory approval for a drug. It is possible that the FDA and/or foreign health authorities may refuse\plain\cf1\f51\fs20\qj to accept our NDA (or corresponding application) for substantive review or may conclude after review of our data that our\plain\cf1\f51\fs20\qj application is insufficient to obtain regulatory approval of brincidofovir.
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj As an example, the control for the AdVise trial is a historic control, which means that the clinical outcomes as recorded for\plain\cf1\f51\fs20\qj similar patients at the same institutions that are participating in enrollment for AdVise will be used as the comparison for the\plain\cf1\f51\fs20\qj patients who are enrolling in our pivotal trial for the treatment of adenovirus infection. Each subject enrolled in AdVise will have\plain\cf1\f51\fs20\qj up to three matched controls for clinical outcomes including mortality. Trials which employ historic controls have specific risks\plain\cf1\f51\fs20\qj which are unique and are in addition to risks of trials which randomize some patients to placebo or to an active comparator drug.\plain\cf1\f51\fs20\qj Regulatory review of these trials may incur additional risks. In September 2015, the\~FDA recommended that the initial New Drug\plain\cf1\f51\fs20\qj Application for brincidofovir be reviewed for efficacy based only on data from SUPPRESS. We\~will continue to prepare data\plain\cf1\f51\fs20\qj from the AdVise trial, including its historical matched controls, to review with the\~FDA\~to determine the regulatory pathway for\plain\cf1\f51\fs20\qj the treatment of adenovirus. There is no guarantee that we and the FDA will reach agreement on a development pathway for the\plain\cf1\f51\fs20\qj use of brincidofovir for the treatment of adenovirus.
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj If the FDA and/or foreign health authorities do not accept or approve our application(s) for CMV and/or AdV, we may be\plain\cf1\f51\fs20\qj required to conduct additional clinical, nonclinical or manufacturing validation studies and submit those data before\plain\cf1\f51\fs20\qj reconsideration of our application occurs. Depending on the extent of these or any other required studies, approval of any NDA\plain\cf1\f51\fs20\qj or application that we submit may be delayed by several years, or may require us to expend more resources than we have\plain\cf1\f51\fs20\qj available. It is also possible that additional studies, if performed and completed, may not be considered sufficient by the FDA\plain\cf1\f51\fs20\qj and/or foreign health authorities to approve our NDA/application.\par\pard\plain\cf1\f51\fs20\qj \~\par\pard\plain\cf1\f51\fs20\qj Any delay in obtaining, or an inability to obtain, regulatory approvals would prevent us from commercializing brincidofovir,\plain\cf1\f51\fs20\qj generating revenues and achieving and sustaining profitability. If any of these outcomes occur, we may be forced to abandon our\plain\cf1\f51\fs20\qj development efforts for brincidofovir, which would have a material adverse effect on our business and could potentially cause us\plain\cf1\f51\fs20\qj to cease operations.\par\pard\plain\cf1\f51\fs20\b\i\qj \~
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qc 30
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\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\b\i\qj We depend on the successful completion of clinical trials for our product candidates, including brincidofovir. The positive\plain\cf1\f51\fs20\b\i\qj clinical results obtained for our product candidates in prior clinical studies may not be repeated in future clinical studies.*\par\pard\plain\cf1\f51\fs20\qj \~\par\pard\plain\cf1\f51\fs20\qj Before obtaining regulatory approval for the sale of our product candidates, including brincidofovir, we must conduct extensive\plain\cf1\f51\fs20\qj clinical trials to demonstrate the safety and efficacy of our product candidates in humans. Clinical testing is expensive, difficult to\plain\cf1\f51\fs20\qj design and implement, can take many years to complete and is uncertain as to outcome. A failure of one or more of our clinical\plain\cf1\f51\fs20\qj trials can occur at any stage of testing. The outcome of preclinical testing and early clinical trials may not be predictive of the\plain\cf1\f51\fs20\qj success of later clinical trials, and interim results of a clinical trial do not necessarily predict final results. Moreover, preclinical\plain\cf1\f51\fs20\qj and clinical data are often susceptible to varying interpretations and analyses, and many companies that have believed their\plain\cf1\f51\fs20\qj product candidates performed satisfactorily in preclinical studies and clinical trials have nonetheless failed to obtain marketing\plain\cf1\f51\fs20\qj approval for their products.
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj We have completed a Phase 2 clinical study of brincidofovir for the prevention of CMV infection in HCT recipients and a Phase\plain\cf1\f51\fs20\qj 2 study of brincidofovir as preemptive therapy for AdV infection in HCT recipients. However, we have never completed a\plain\cf1\f51\fs20\qj pivotal Phase 3 clinical trial. The positive results we have seen to date in our Phase 2 clinical trial of brincidofovir for the\plain\cf1\f51\fs20\qj prevention of CMV in HCT recipients and the encouraging data from our Phase 2 trial of brincidofovir as preemptive therapy for\plain\cf1\f51\fs20\qj asymptomatic AdV infection do not ensure that later clinical trials, such as our ongoing Phase 3 SUPPRESS trial and our AdVise\plain\cf1\f51\fs20\qj trial, and any additional Phase 3 clinical trials, such as SUSTAIN and SURPASS, will demonstrate similar results. Product\plain\cf1\f51\fs20\qj candidates in later stages of clinical trials may fail to show the desired safety and efficacy characteristics despite having\plain\cf1\f51\fs20\qj progressed satisfactorily through preclinical studies and initial clinical testing. A number of companies in the pharmaceutical and\plain\cf1\f51\fs20\qj biotechnology industries, including those with greater resources and experience than us, have suffered significant setbacks in\plain\cf1\f51\fs20\qj Phase 3 clinical development, even after seeing promising results in earlier clinical trials.
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj We may experience a number of unforeseen events during, or as a result of, clinical trials for our product candidates, including\plain\cf1\f51\fs20\qj brincidofovir, that could adversely affect the completion of our clinical trials, including:\par\pard\plain\cf1\f51\fs20\ql \~
\par\pard\plain
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\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx1080\clvertalc\cellx10800\trrh-66\row}}}
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj regulators or institutional review boards may not authorize us or our investigators to commence a clinical trial or\plain\intbl\cf1\f51\fs20\qj conduct a clinical trial at a prospective trial site;\cell{
{\trowd\cellx1080\cellx10800\trrh495\row}}}
\pard\plain
{\trowd\clvertalc\cellx1080\clvertalc\cellx10800\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx1080\clvertalc\cellx10800\trrh-66\row}}}
{\trowd\cellx1080\cellx10800\trrh495
\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj clinical trials of our product candidates may produce negative or inconclusive results, and we may decide, or\plain\intbl\cf1\f51\fs20\qj regulators may require us, to conduct additional clinical trials or abandon product development programs;\cell{
{\trowd\cellx1080\cellx10800\trrh495\row}}}
\pard\plain
{\trowd\clvertalc\cellx1075\clvertalc\cellx10695\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx1075\clvertalc\cellx10695\trrh-66\row}}}
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj we might be required to change one of our clinical research organizations (CROs) during ongoing clinical\plain\intbl\cf1\f51\fs20\qj programs;\cell{
{\trowd\cellx1075\cellx10695\trrh495\row}}}
\pard\plain
{\trowd\clvertalc\cellx1080\clvertalc\cellx10800\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx1080\clvertalc\cellx10800\trrh-66\row}}}
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj the number of subjects required for clinical trials of our product candidates may be larger than we anticipate,\plain\intbl\cf1\f51\fs20\qj enrollment in these clinical trials may be insufficient or slower than we anticipate or subjects may drop out of these\plain\intbl\cf1\f51\fs20\qj clinical trials at a higher rate than we anticipate;\cell{
{\trowd\cellx1080\cellx10800\trrh742\row}}}
\pard\plain
{\trowd\clvertalc\cellx1080\clvertalc\cellx10800\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx1080\clvertalc\cellx10800\trrh-66\row}}}
{\trowd\cellx1080\cellx10800\trrh495
\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj our third-party contractors may fail to comply with regulatory requirements or meet their contractual obligations to\plain\intbl\cf1\f51\fs20\qj us in a timely manner, or at all;\cell{
{\trowd\cellx1080\cellx10800\trrh495\row}}}
\pard\plain
{\trowd\clvertalc\cellx1080\clvertalc\cellx10800\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx1080\clvertalc\cellx10800\trrh-66\row}}}
{\trowd\cellx1080\cellx10800\trrh495
\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj we might have to suspend or terminate clinical trials of our product candidates for various reasons, including a\plain\intbl\cf1\f51\fs20\qj finding that the subjects are being exposed to unacceptable health risks;\cell{
{\trowd\cellx1080\cellx10800\trrh495\row}}}
\pard\plain
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\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx1080\clvertalc\cellx10800\trrh-66\row}}}
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj regulators or institutional review boards may require that we or our investigators suspend or terminate clinical\plain\intbl\cf1\f51\fs20\qj research for various reasons, including noncompliance with regulatory requirements;\cell{
{\trowd\cellx1080\cellx10800\trrh495\row}}}
\pard\plain
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\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx957\clvertalc\cellx7607\trrh-66\row}}}
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj the cost of clinical trials of our product candidates may be greater than we\plain\intbl\cf1\f51\fs20\qj anticipate;\cell{
{\trowd\cellx957\cellx7607\trrh495\row}}}
\pard\plain
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\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx895\clvertalc\cellx6073\trrh-66\row}}}
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj agency or judicial enforcement actions which impact our\plain\intbl\cf1\f51\fs20\qj clinical trials;\cell{
{\trowd\cellx895\cellx6073\trrh495\row}}}
\pard\plain
{\trowd\clvertalc\cellx1080\clvertalc\cellx10800\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx1080\clvertalc\cellx10800\trrh-66\row}}}
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj the supply or quality of our product candidates or other materials necessary to conduct clinical trials of our product\plain\intbl\cf1\f51\fs20\qj candidates may be insufficient or inadequate; and\cell{
{\trowd\cellx1080\cellx10800\trrh495\row}}}
\pard\plain
{\trowd\clvertalc\cellx1080\clvertalc\cellx10800\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx1080\clvertalc\cellx10800\trrh-66\row}}}
{\trowd\cellx1080\cellx10800\trrh495
\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj our product candidates may have undesirable side effects or other unexpected characteristics, causing us or our\plain\intbl\cf1\f51\fs20\qj investigators to suspend or terminate the trials.\cell{
{\trowd\cellx1080\cellx10800\trrh495\row}}}
\par\pard\plain\fs16\pard\plain\cf1\f51\fs20\qj Negative or inconclusive results of our Phase 3 SUPPRESS trial and our AdVise trial of brincidofovir, or any other clinical trial\plain\cf1\f51\fs20\qj we conduct, could cause the FDA and/or foreign health authorities to require that we repeat or conduct additional clinical studies.\plain\cf1\f51\fs20\qj Despite the results reported in earlier clinical trials for brincidofovir, we do not know whether SUPPRESS, AdVise, or any other\plain\cf1\f51\fs20\qj clinical trials we may conduct will demonstrate adequate efficacy and safety to result in regulatory approval to market our\plain\cf1\f51\fs20\qj product candidates, including brincidofovir. If later stage clinical trials do not produce favorable results, our ability to obtain\plain\cf1\f51\fs20\qj regulatory approval for our product candidates, including brincidofovir, may be adversely impacted.\par\pard\plain\cf1\f51\fs20\qj \~\par\pard\plain\cf1\f51\fs20\b\i\qj We are developing brincidofovir to treat patients who are extremely ill, and patient deaths that occur in our clinical trials\plain\cf1\f51\fs20\b\i\qj could negatively impact our business even if they are not shown to be related to brincidofovir.*\par\pard\plain\cf1\f51\fs20\qj \~\par\pard\plain\cf1\f51\fs20\qj We are developing our lead product candidate, brincidofovir, for the prevention of CMV infection in HCT recipients through the\plain\cf1\f51\fs20\qj Phase 3 SUPPRESS trial, and for the treatment of adenovirus infection through the AdVise trial. Many of these patients receive
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\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj an HCT as a potential cure or remission for many cancers and genetic disorders. Patients enrolled in AdVise are often extremely\plain\cf1\f51\fs20\qj sick and have a high likelihood of experiencing adverse outcomes as a result of their infection. To prepare for an HCT, patients\plain\cf1\f51\fs20\qj receive a pre-transplant conditioning regimen, which involves high-dose chemotherapy and may also include radiation therapy.\plain\cf1\f51\fs20\qj The conditioning regimen suppresses the patient's immune system in order to prevent it from attacking the new bone marrow.
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj We have initiated two Phase 3 studies, SUSTAIN and SURPASS, of brincidofovir for the prevention of CMV infection in kidney\plain\cf1\f51\fs20\qj transplant recipients. In the setting of a kidney, or other transplant, immunosuppressive therapies are administered to decrease the\plain\cf1\f51\fs20\qj risk of organ rejection and are generally tapered after the first few months; the risk of severe viral infection is highest in the first\plain\cf1\f51\fs20\qj few months. Generally, patients remain at high risk during the first 100 to 200 days following their transplant and are at\plain\cf1\f51\fs20\qj increased risk of infections during that period, which can be serious and even life-threatening due to their weakened immune\plain\cf1\f51\fs20\qj systems.
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj As a result, it is likely that we will observe severe adverse outcomes during our clinical trials for brincidofovir, including patient\plain\cf1\f51\fs20\qj death. If a significant number of study subject deaths were to occur, regardless of whether such deaths are attributable to\plain\cf1\f51\fs20\qj brincidofovir, our ability to obtain regulatory approval and/or achieve commercial acceptance for brincidofovir may be adversely\plain\cf1\f51\fs20\qj impacted and our business could be materially harmed.
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\b\i\qj Delays in clinical trials are common and have many causes, and any delay could result in increased costs to us and jeopardize\plain\cf1\f51\fs20\b\i\qj or delay our ability to obtain regulatory approval and commence product sales.*\par\pard\plain\cf1\f51\fs20\qj \~\par\pard\plain\cf1\f51\fs20\qj Clinical testing is expensive, difficult to design and implement, can take many years to complete, and is uncertain as to outcome.\plain\cf1\f51\fs20\qj We may experience delays in clinical trials at any stage of development and testing of our product candidates. Our planned\plain\cf1\f51\fs20\qj clinical trials may not begin on time, have an effective design, enroll a sufficient number of subjects, or be completed on\plain\cf1\f51\fs20\qj schedule, if at all.
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj Events which may result in a delay or unsuccessful completion of clinical trials, including our Phase 3 clinical trials for\plain\cf1\f51\fs20\qj brincidofovir, include:
\par\pard\plain\fs16
\pard\plain
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj inability to raise funding necessary to initiate or\plain\intbl\cf1\f51\fs20\qj continue a trial;\cell{
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\pard\plain
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\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj delays in obtaining regulatory approval to\plain\intbl\cf1\f51\fs20\qj commence a trial;\cell{
{\trowd\cellx857\cellx5048\trrh495\row}}}
\pard\plain
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\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx991\clvertalc\cellx8590\trrh-66\row}}}
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj delays in reaching agreement with the FDA and foreign health authorities on final trial\plain\intbl\cf1\f51\fs20\qj design;\cell{
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\pard\plain
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\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx1080\clvertalc\cellx10800\trrh-66\row}}}
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj imposition of a clinical hold following an inspection of our clinical trial operations or trial sites by the FDA or other\plain\intbl\cf1\f51\fs20\qj regulatory authorities;\cell{
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\pard\plain
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\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx918\clvertalc\cellx6774\trrh-66\row}}}
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj delays caused by disagreements with existing CROs and/or clinical\plain\intbl\cf1\f51\fs20\qj trial sites;\cell{
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\pard\plain
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\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj delays in reaching agreement on acceptable terms with prospective CROs and clinical trial\plain\intbl\cf1\f51\fs20\qj sites;\cell{
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\pard\plain
{\trowd\clvertalc\cellx915\clvertalc\cellx6561\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
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{\trowd\cellx915\cellx6561\trrh495
\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj delays in obtaining required institutional review board approval at\plain\intbl\cf1\f51\fs20\qj each site;\cell{
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\pard\plain
{\trowd\clvertalc\cellx856\clvertalc\cellx5008\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj delays in recruiting suitable patients to participate\plain\intbl\cf1\f51\fs20\qj in a trial;\cell{
{\trowd\cellx856\cellx5008\trrh495\row}}}
\pard\plain
{\trowd\clvertalc\cellx996\clvertalc\cellx8996\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx996\clvertalc\cellx8996\trrh-66\row}}}
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj delays in having subjects complete participation in a trial or return for post-treatment\plain\intbl\cf1\f51\fs20\qj follow-up;\cell{
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\pard\plain
{\trowd\clvertalc\cellx941\clvertalc\cellx7156\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx941\clvertalc\cellx7156\trrh-66\row}}}
{\trowd\cellx941\cellx7156\trrh495
\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj delays caused by subjects dropping out of a trial due to side effects or\plain\intbl\cf1\f51\fs20\qj otherwise;\cell{
{\trowd\cellx941\cellx7156\trrh495\row}}}
\pard\plain
{\trowd\clvertalc\cellx882\clvertalc\cellx5701\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx882\clvertalc\cellx5701\trrh-66\row}}}
{\trowd\cellx882\cellx5701\trrh495
\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj clinical sites dropping out of a trial to the detriment of\plain\intbl\cf1\f51\fs20\qj enrollment;\cell{
{\trowd\cellx882\cellx5701\trrh495\row}}}
\pard\plain
{\trowd\clvertalc\cellx811\clvertalc\cellx4190\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx811\clvertalc\cellx4190\trrh-66\row}}}
{\trowd\cellx811\cellx4190\trrh495
\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj agency or judicial enforcement actions\plain\intbl\cf1\f51\fs20\qj against us;\cell{
{\trowd\cellx811\cellx4190\trrh495\row}}}
\pard\plain
{\trowd\clvertalc\cellx798\clvertalc\cellx3603\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx798\clvertalc\cellx3603\trrh-66\row}}}
{\trowd\cellx798\cellx3603\trrh495
\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj time required to add new clinical\plain\intbl\cf1\f51\fs20\qj sites; and\cell{
{\trowd\cellx798\cellx3603\trrh495\row}}}
\pard\plain
{\trowd\clvertalc\cellx1021\clvertalc\cellx9543\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx1021\clvertalc\cellx9543\trrh-66\row}}}
{\trowd\cellx1021\cellx9543\trrh495
\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj delays by our contract manufacturers to produce and deliver sufficient supply of clinical trial\plain\intbl\cf1\f51\fs20\qj materials.\cell{
{\trowd\cellx1021\cellx9543\trrh495\row}}}
\par\pard\plain\fs16\pard\plain\cf1\f51\fs20\qj For example, due to the specialized indication and patient populations being studied in our Phase 3 clinical trials of brincidofovir,\plain\cf1\f51\fs20\qj the number of study sites available to us is relatively limited, and therefore enrollment of suitable patients to participate in the\plain\cf1\f51\fs20\qj trial may take longer than is typical for studies involving other indications. This may result in a delay or unsuccessful completion\plain\cf1\f51\fs20\qj of our clinical trials, including our Phase 3 clinical trials of brincidofovir for CMV prevention in solid organ transplant recipients.
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj If initiation or completion of any of our clinical trials for our product candidates, including our current or future Phase 3 clinical\plain\cf1\f51\fs20\qj trials of brincidofovir, are delayed for any of the above reasons, our development costs may increase, our approval process could\plain\cf1\f51\fs20\qj be delayed, any periods during which we may have the exclusive right to commercialize our product candidates may be reduced\plain\cf1\f51\fs20\qj and our competitors may have more time to bring products to market before we do. Any of these events could impair our ability\plain\cf1\f51\fs20\qj to generate revenues from product sales and impair our ability to generate regulatory and commercialization milestones and\plain\cf1\f51\fs20\qj royalties, all of which could have a material adverse effect on our business.\par\pard\plain\cf1\f51\fs20\b\i\qj \~
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qc 32
\par\pard\plain\fs16\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par
\page
\par\pard\plain\fs16
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\b\i\qj Our product candidates may cause adverse effects or have other properties that could delay or prevent their regulatory\plain\cf1\f51\fs20\b\i\qj approval or limit the scope of any approved label or market acceptance.\par\pard\plain\cf1\f51\fs20\qj \~\par\pard\plain\cf1\f51\fs20\qj Adverse events (AEs) caused by our product candidates could cause us, other reviewing entities, clinical study sites or regulatory\plain\cf1\f51\fs20\qj authorities to interrupt, delay or halt clinical studies and could result in the denial of regulatory approval. For example, subjects\plain\cf1\f51\fs20\qj enrolled in our Phase 2 clinical trials for brincidofovir have reported gastrointestinal AEs and liver-related safety laboratory value\plain\cf1\f51\fs20\qj changes. In addition, brincidofovir is related to the approved drug cidofovir (CDV), a compound which has been shown to result\plain\cf1\f51\fs20\qj in significant renal toxicity and impairment following use. There is also a risk that our other product candidates may induce AEs,\plain\cf1\f51\fs20\qj many of which may be unknown at this time. If an unacceptable frequency and/or severity of AEs are reported in our clinical\plain\cf1\f51\fs20\qj trials for our product candidates, our ability to obtain regulatory approval for product candidates, including brincidofovir, may be\plain\cf1\f51\fs20\qj negatively impacted.
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj If any of our approved products cause serious or unexpected side effects prior to or after receiving market approval, a number of\plain\cf1\f51\fs20\qj potentially significant negative consequences could result, including:\par\pard\plain\cf1\f51\fs20\qj \~
\par\pard\plain
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\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx1080\clvertalc\cellx10293\trrh-66\row}}}
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj regulatory authorities may withdraw their approval of the product or impose restrictions on its distribution in a\plain\intbl\cf1\f51\fs20\qj form of a modified risk evaluation and mitigation strategy (REMS);\cell{
{\trowd\cellx1080\cellx10293\trrh495\row}}}
\pard\plain
{\trowd\clvertalc\cellx1038\clvertalc\cellx9942\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx1038\clvertalc\cellx9942\trrh-66\row}}}
{\trowd\cellx1038\cellx9942\trrh495
\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj regulatory authorities may require the addition of labeling statements, such as warnings or\plain\intbl\cf1\f51\fs20\qj contraindications;\cell{
{\trowd\cellx1038\cellx9942\trrh495\row}}}
\pard\plain
{\trowd\clvertalc\cellx1041\clvertalc\cellx9963\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx1041\clvertalc\cellx9963\trrh-66\row}}}
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj we may be required to change the way the product is administered or to conduct additional clinical studies;\cell{
{\trowd\cellx1041\cellx9963\trrh248\row}}}
\pard\plain
{\trowd\clvertalc\cellx885\clvertalc\cellx5568\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx885\clvertalc\cellx5568\trrh-66\row}}}
{\trowd\cellx885\cellx5568\trrh495
\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj we could be sued and held liable for harm caused to\plain\intbl\cf1\f51\fs20\qj patients; and\cell{
{\trowd\cellx885\cellx5568\trrh495\row}}}
\pard\plain
{\trowd\clvertalc\cellx725\clvertalc\cellx2445\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx725\clvertalc\cellx2445\trrh-66\row}}}
{\trowd\cellx725\cellx2445\trrh495
\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj our reputation may\plain\intbl\cf1\f51\fs20\qj suffer.\cell{
{\trowd\cellx725\cellx2445\trrh495\row}}}
\par\pard\plain\fs16\pard\plain\cf1\f51\fs20\qj Any of these events could prevent us from achieving or maintaining market acceptance of the affected product candidate and\plain\cf1\f51\fs20\qj could substantially increase the costs of commercializing our product candidates.
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\b\i\qj After the completion of our clinical trials, we cannot predict whether or when we will obtain regulatory approval to\plain\cf1\f51\fs20\b\i\qj commercialize brincidofovir and we cannot, therefore, predict the timing of any future revenue from brincidofovir.\par\pard\plain\cf1\f51\fs20\qj \~\par\pard\plain\cf1\f51\fs20\qj We cannot commercialize our product candidates, including brincidofovir, until the appropriate regulatory authorities have\plain\cf1\f51\fs20\qj reviewed and approved the product candidate. The regulatory agencies may not complete their review processes in a timely\plain\cf1\f51\fs20\qj manner, or we may not be able to obtain regulatory approval for brincidofovir. Additional delays in the United States may result\plain\cf1\f51\fs20\qj if brincidofovir is brought before an FDA advisory committee, which could recommend restrictions on approval or recommend\plain\cf1\f51\fs20\qj non-approval of the product candidate. In addition, we may experience delays or rejections based upon additional government\plain\cf1\f51\fs20\qj regulation from future legislation or administrative action, or changes in regulatory agency policy during the period of product\plain\cf1\f51\fs20\qj development, clinical studies and the review process. As a result, we cannot predict when, if at all, we will receive any future\plain\cf1\f51\fs20\qj revenue from commercialization of any of our product candidates, including brincidofovir.
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\b\i\qj Even if we obtain regulatory approval for brincidofovir and our other product candidates, we will still face extensive\plain\cf1\f51\fs20\b\i\qj regulatory requirements and our products may face future development and regulatory difficulties.\par\pard\plain\cf1\f51\fs20\qj \~\par\pard\plain\cf1\f51\fs20\qj Even if we obtain regulatory approval, the granting authority may still impose significant restrictions on the indicated uses or\plain\cf1\f51\fs20\qj marketing of our product candidates, including brincidofovir, or impose ongoing requirements for potentially costly post-approval\plain\cf1\f51\fs20\qj studies or post-market surveillance. For example, the labeling ultimately approved for our product candidates, including\plain\cf1\f51\fs20\qj brincidofovir, will likely include restrictions on use due to the specific patient population and manner of use in which the drug\plain\cf1\f51\fs20\qj was evaluated and the safety and efficacy data obtained in those evaluations. In addition, the label for brincidofovir may be\plain\cf1\f51\fs20\qj required to include a boxed warning, or \u8220?black box,\u8221? regarding brincidofovir being carcinogenic, teratogenic and\plain\cf1\f51\fs20\qj impairing fertility in animal studies, as well as a contraindication in patients who have had a demonstrated clinically significant\plain\cf1\f51\fs20\qj hypersensitivity reaction to brincidofovir or CDV or any component of the formulation. The brincidofovir labeling may also\plain\cf1\f51\fs20\qj include warnings or black boxes pertaining to gastrointestinal AEs or liver-related safety laboratory value changes.
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj Brincidofovir and our other product candidates will also be subject to additional ongoing regulatory requirements governing the\plain\cf1\f51\fs20\qj labeling, packaging, storage, distribution, safety surveillance, advertising, promotion, record-keeping and reporting of safety and\plain\cf1\f51\fs20\qj other post-market information. In the United States, the holder of an approved NDA is obligated to monitor and report AEs and\plain\cf1\f51\fs20\qj any failure of a product to meet the specifications in the NDA. The holder of an approved NDA must also submit new or\plain\cf1\f51\fs20\qj supplemental applications and obtain FDA approval for certain changes to the approved product, product labeling or\plain\cf1\f51\fs20\qj manufacturing process. Advertising and promotional materials must comply with FDA rules and are subject to FDA review, in\plain\cf1\f51\fs20\qj addition to other potentially applicable federal and state laws. Furthermore, promotional materials must be approved by the FDA\plain\cf1\f51\fs20\qj prior to use for any drug receiving accelerated approval, the pathway that we are pursuing for an initial marketing approval of\plain\cf1\f51\fs20\qj brincidofovir in the United States for prevention of CMV in HCT recipients.
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qc 33
\par\pard\plain\fs16\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par
\page
\par\pard\plain\fs16
\par\pard\plain\fs16
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj In addition, manufacturers of drug products and their facilities are subject to payment of user fees and continual review and\plain\cf1\f51\fs20\qj periodic inspections by regulatory authorities for compliance with current good manufacturing practices (cGMP), and adherence\plain\cf1\f51\fs20\qj to commitments made in the application. If we, or a regulatory agency, discover previously unknown problems with a product,\plain\cf1\f51\fs20\qj such as quality issues or AEs of unanticipated severity or frequency, or problems with the facility where the product is\plain\cf1\f51\fs20\qj manufactured, a regulatory agency may impose restrictions relative to that product or the manufacturing facility, including\plain\cf1\f51\fs20\qj requiring recall or withdrawal of the product from the market or suspension of manufacturing.
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj If we fail to comply with applicable regulatory requirements following approval of our product candidate, a regulatory agency\plain\cf1\f51\fs20\qj may:
\par\pard\plain
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\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx934\clvertalc\cellx6853\trrh-66\row}}}
{\trowd\cellx934\cellx6853\trrh495
\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj issue an untitled or warning letter asserting that we are in violation of\plain\intbl\cf1\f51\fs20\qj the law;\cell{
{\trowd\cellx934\cellx6853\trrh495\row}}}
\pard\plain
{\trowd\clvertalc\cellx912\clvertalc\cellx6356\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx912\clvertalc\cellx6356\trrh-66\row}}}
{\trowd\cellx912\cellx6356\trrh495
\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj seek an injunction or impose civil or criminal penalties or\plain\intbl\cf1\f51\fs20\qj monetary fines;\cell{
{\trowd\cellx912\cellx6356\trrh495\row}}}
\pard\plain
{\trowd\clvertalc\cellx783\clvertalc\cellx3470\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx783\clvertalc\cellx3470\trrh-66\row}}}
{\trowd\cellx783\cellx3470\trrh495
\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj suspend or withdraw regulatory\plain\intbl\cf1\f51\fs20\qj approval;\cell{
{\trowd\cellx783\cellx3470\trrh495\row}}}
\pard\plain
{\trowd\clvertalc\cellx766\clvertalc\cellx2987\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx766\clvertalc\cellx2987\trrh-66\row}}}
{\trowd\cellx766\cellx2987\trrh495
\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj suspend any ongoing\plain\intbl\cf1\f51\fs20\qj clinical trials;\cell{
{\trowd\cellx766\cellx2987\trrh495\row}}}
\pard\plain
{\trowd\clvertalc\cellx970\clvertalc\cellx8098\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx970\clvertalc\cellx8098\trrh-66\row}}}
{\trowd\cellx970\cellx8098\trrh495
\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj refuse to approve a pending application or supplements to an application submitted\plain\intbl\cf1\f51\fs20\qj by us;\cell{
{\trowd\cellx970\cellx8098\trrh495\row}}}
\pard\plain
{\trowd\clvertalc\cellx746\clvertalc\cellx2642\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx746\clvertalc\cellx2642\trrh-66\row}}}
{\trowd\cellx746\cellx2642\trrh495
\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj recall and/or seize\plain\intbl\cf1\f51\fs20\qj product; or\cell{
{\trowd\cellx746\cellx2642\trrh495\row}}}
\pard\plain
{\trowd\clvertalc\cellx935\clvertalc\cellx7073\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx935\clvertalc\cellx7073\trrh-66\row}}}
{\trowd\cellx935\cellx7073\trrh495
\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj refuse to allow us to enter into supply contracts, including government\plain\intbl\cf1\f51\fs20\qj contracts.\cell{
{\trowd\cellx935\cellx7073\trrh495\row}}}
\par\pard\plain\fs16\pard\plain\cf1\f51\fs20\qj Any government investigation of alleged violations of law could require us to expend significant time and resources in response\plain\cf1\f51\fs20\qj and could generate negative publicity. The occurrence of any event or penalty described above may inhibit our ability to\plain\cf1\f51\fs20\qj commercialize brincidofovir and our other product candidates and inhibit our ability to generate revenues.\par\pard\plain\cf1\f51\fs20\qj \~\par\pard\plain\cf1\f51\fs20\b\i\qj Even if we obtain FDA approval for brincidofovir or any of our other products in the United States, we may never obtain\plain\cf1\f51\fs20\b\i\qj approval for or commercialize brincidofovir or any of our other products outside of the United States, which would limit our\plain\cf1\f51\fs20\b\i\qj ability to realize their full market potential.\par\pard\plain\cf1\f51\fs20\qj \~\par\pard\plain\cf1\f51\fs20\qj In order to market any products outside of the United States, we must establish and comply with numerous and varying\plain\cf1\f51\fs20\qj regulatory requirements on a country-by-country basis regarding safety and efficacy. Approval by the FDA does not ensure\plain\cf1\f51\fs20\qj approval by regulatory authorities in other countries or jurisdictions. In addition, clinical trials conducted in one country may not\plain\cf1\f51\fs20\qj be accepted by regulatory authorities in other countries, and regulatory approval in one country does not guarantee regulatory\plain\cf1\f51\fs20\qj approval in any other country. Approval processes vary among countries and can involve additional product testing and validation\plain\cf1\f51\fs20\qj and additional administrative review periods. Seeking foreign regulatory approval could result in difficulties and costs for us and\plain\cf1\f51\fs20\qj require additional preclinical studies or clinical trials which could be costly and time consuming. Regulatory requirements can\plain\cf1\f51\fs20\qj vary widely from country to country and could delay or prevent the introduction of our products in those countries. We do not\plain\cf1\f51\fs20\qj have any product candidates approved for sale in any jurisdiction, including international markets, and we do not have experience\plain\cf1\f51\fs20\qj in obtaining regulatory approval in any markets. If we fail to comply with regulatory requirements in international markets or to\plain\cf1\f51\fs20\qj obtain and maintain required approvals, or if regulatory approvals in international markets are delayed, our target market will be\plain\cf1\f51\fs20\qj reduced and our ability to realize the full market potential of our products will be unrealized.\par\pard\plain\cf1\f51\fs20\qj \~\par\pard\plain\cf1\f51\fs20\b\i\qj Our relationships with investigators, health care professionals, consultants, third-party payers, and customers are subject to\plain\cf1\f51\fs20\b\i\qj applicable anti-kickback, fraud and abuse and other healthcare laws and regulations, which could expose us to criminal\plain\cf1\f51\fs20\b\i\qj sanctions, civil penalties, contractual damages, reputational harm and diminished profits and future earnings.\par\pard\plain\cf1\f51\fs20\qj \~\par\pard\plain\cf1\f51\fs20\qj Healthcare providers, physicians and others play a primary role in the recommendation and prescribing of any products for which\plain\cf1\f51\fs20\qj we obtain marketing approval. Our current business operations and future arrangements with investigators, healthcare\plain\cf1\f51\fs20\qj professionals, consultants, third-party payers and customers may expose us to broadly applicable fraud and abuse and other\plain\cf1\f51\fs20\qj healthcare laws and regulations. These laws may constrain the business or financial arrangements and relationships through which\plain\cf1\f51\fs20\qj we research, market, sell and distribute our products for which we obtain marketing approval. Restrictions under applicable\plain\cf1\f51\fs20\qj federal and state healthcare laws and regulations, include, but are not limited to, the following:\par\pard\plain\cf1\f51\fs20\qj \~
\par\pard\plain
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\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx1080\clvertalc\cellx10800\trrh-66\row}}}
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj the federal healthcare anti-kickback statute which prohibits, among other things, persons or entities from knowingly\plain\intbl\cf1\f51\fs20\qj and willfully soliciting, offering, receiving or paying remuneration (including any kickback, bribe or rebate), directly\plain\intbl\cf1\f51\fs20\qj or indirectly, overtly or covertly, in cash or in kind, to induce or reward either the referral of an individual for, or\plain\intbl\cf1\f51\fs20\qj the purchase, lease, order or recommendation of, any good, facility, item or service, for which payment may be\plain\intbl\cf1\f51\fs20\qj made, in whole or in part, under federal healthcare programs such as Medicare and Medicaid;\cell{
{\trowd\cellx1080\cellx10800\trrh1238\row}}}
\pard\plain
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\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx1080\clvertalc\cellx10800\trrh-66\row}}}
{\trowd\cellx1080\cellx10800\trrh742
\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj the federal civil and criminal false claims laws and civil monetary penalties, including civil whistleblower or\plain\intbl\cf1\f51\fs20\i\qj qui tam\plain\intbl\cf1\f51\fs20\qj actions, which prohibit, among other things, individuals or entities from knowingly presenting, or causing to be\plain\intbl\cf1\f51\fs20\qj presented, to the federal government, claims for payment or approval that are false or fraudulent or from knowingly\cell{
{\trowd\cellx1080\cellx10800\trrh742\row}}}
\par\pard\plain\fs16\pard\plain\cf1\f51\fs20\qc 34
\par\pard\plain\fs16\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par
\page
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\par\pard\plain\fs16\par\pard\plain\li1188\cf1\f51\fs20\qj making a false statement to improperly avoid, decrease or conceal an obligation to pay money to the federal\plain\li1188\cf1\f51\fs20\qj government;
\par\pard\plain
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\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx1080\clvertalc\cellx10800\trrh-66\row}}}
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj the federal Health Insurance Portability and Accountability Act of 1996 (HIPAA) which, among other things,\plain\intbl\cf1\f51\fs20\qj imposes criminal liability for knowingly and willfully executing, or attempting to execute, a scheme to defraud any\plain\intbl\cf1\f51\fs20\qj healthcare benefit program or to obtain, by means of false or fraudulent pretenses, representations, or promises, any\plain\intbl\cf1\f51\fs20\qj of the money or property owned by, or under the custody or control of, any healthcare benefit program, regardless\plain\intbl\cf1\f51\fs20\qj of the payer (e.g., public or private) and knowingly or willfully falsifying, concealing or covering up by any trick or\plain\intbl\cf1\f51\fs20\qj device a material fact or making any materially false statement in connection with the delivery of, or payment for,\plain\intbl\cf1\f51\fs20\qj healthcare benefits, items or services relating to healthcare matters;\cell{
{\trowd\cellx1080\cellx10800\trrh1732\row}}}
\pard\plain
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\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx1080\clvertalc\cellx10800\trrh-66\row}}}
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj HIPAA, as amended by the Health Information Technology for Economic and Clinical Health Act (HITECH) and its\plain\intbl\cf1\f51\fs20\qj implementing regulations, and as amended again by the final HIPAA omnibus rule, Modifications to the HIPAA\plain\intbl\cf1\f51\fs20\qj Privacy, Security, Enforcement, and Breach Notification Rules Under HITECH and the Genetic Information\plain\intbl\cf1\f51\fs20\qj Nondiscrimination Act; Other Modifications to HIPAA, published in January 2013, which imposes certain\plain\intbl\cf1\f51\fs20\qj obligations, including mandatory contractual terms, with respect to safeguarding the privacy, security and\plain\intbl\cf1\f51\fs20\qj transmission of individually identifiable health information without appropriate authorization by entities subject to\plain\intbl\cf1\f51\fs20\qj the rule, such as health plans, clearinghouses and healthcare providers;\cell{
{\trowd\cellx1080\cellx10800\trrh1732\row}}}
\pard\plain
{\trowd\clvertalc\cellx1080\clvertalc\cellx10800\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx1080\clvertalc\cellx10800\trrh-66\row}}}
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj the federal Food, Drug and Cosmetic Act (FDCA) which prohibits, among other things, the adulteration or\plain\intbl\cf1\f51\fs20\qj misbranding of drugs and devices;\cell{
{\trowd\cellx1080\cellx10800\trrh495\row}}}
\pard\plain
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\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx1080\clvertalc\cellx10800\trrh-66\row}}}
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj the federal transparency law, enacted as part of the Patient Protection and Affordable Care Act and Health Care and\plain\intbl\cf1\f51\fs20\qj Education Reconciliation Act of 2010 (collectively, the Health Care Reform Law), and its implementing regulations,\plain\intbl\cf1\f51\fs20\qj which requires manufacturers of drugs, devices, biologicals and medical supplies to report to the U.S. Department of\plain\intbl\cf1\f51\fs20\qj Health and Human Services information related to payments and other transfers of value made to physicians and\plain\intbl\cf1\f51\fs20\qj teaching hospitals, as well as ownership and investment interests held by physicians and their immediate family\plain\intbl\cf1\f51\fs20\qj members; and\cell{
{\trowd\cellx1080\cellx10800\trrh1485\row}}}
\pard\plain
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\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx1080\clvertalc\cellx10800\trrh-66\row}}}
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj analogous state laws and regulations, including: state anti-kickback and false claims laws, which may apply to our\plain\intbl\cf1\f51\fs20\qj business practices, including but not limited to, research, distribution, sales and marketing arrangements and claims\plain\intbl\cf1\f51\fs20\qj involving healthcare items or services reimbursed by state governmental and non-governmental third-party payers,\plain\intbl\cf1\f51\fs20\qj including private insurers; state laws that require pharmaceutical companies to comply with the pharmaceutical\plain\intbl\cf1\f51\fs20\qj industry\u8217?s voluntary compliance guidelines and the relevant compliance guidance promulgated by the federal\plain\intbl\cf1\f51\fs20\qj government; and state laws and regulations that require manufacturers to file reports relating to pricing and\plain\intbl\cf1\f51\fs20\qj marketing information, which requires tracking gifts and other remuneration and items of value provided to\plain\intbl\cf1\f51\fs20\qj healthcare professionals and entities.\cell{
{\trowd\cellx1080\cellx10800\trrh1980\row}}}
\par\pard\plain\fs16\pard\plain\cf1\f51\fs20\qj Efforts to ensure that our business arrangements with third parties will comply with applicable healthcare laws and regulations\plain\cf1\f51\fs20\qj will involve substantial costs. It is possible that governmental authorities will conclude that our business practices may not\plain\cf1\f51\fs20\qj comply with current or future statutes, regulations, agency guidance or case law involving applicable fraud and abuse or other\plain\cf1\f51\fs20\qj healthcare laws and regulations. If our operations are found to be in violation of any of these or any other health regulatory laws\plain\cf1\f51\fs20\qj or any other governmental regulations that may apply to us, we may be subject to significant civil, criminal and administrative\plain\cf1\f51\fs20\qj penalties, damages, fines, exclusion from government funded healthcare programs, such as Medicare and Medicaid, and the\plain\cf1\f51\fs20\qj curtailment or restructuring of our operations, any of which could adversely affect our ability to operate our business and our\plain\cf1\f51\fs20\qj financial results. Any action against us for violation of these laws, even if we successfully defend against it, could cause us to\plain\cf1\f51\fs20\qj incur significant legal expenses or divert our management\u8217?s attention from the operation of our business. If any of the\plain\cf1\f51\fs20\qj physicians or other providers or entities with whom we expect to do business are found to be not in compliance with applicable\plain\cf1\f51\fs20\qj laws, they also may be subject to criminal, civil or administrative sanctions, including, but not limited to, exclusions from\plain\cf1\f51\fs20\qj government funded healthcare programs, which could also materially affect our business.\par\pard\plain\cf1\f51\fs20\qj \~\par\pard\plain\cf1\f51\fs20\b\i\qj Recently enacted and future legislation may increase the difficulty and cost for us to obtain marketing approval of and\plain\cf1\f51\fs20\b\i\qj commercialize our product candidates and affect the prices we may obtain.\par\pard\plain\fi792\cf1\f51\fs20\qj \~\par\pard\plain\cf1\f51\fs20\qj In the United States and some foreign jurisdictions, there have been a number of legislative and regulatory changes and proposed\plain\cf1\f51\fs20\qj changes regarding the healthcare system that could prevent or delay marketing approval of our product candidates, restrict or\plain\cf1\f51\fs20\qj regulate post-approval activities and affect our ability to profitably sell any products for which we obtain marketing approval.
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj In the United States, the Medicare Prescription Drug, Improvement, and Modernization Act of 2003 (Medicare Modernization\plain\cf1\f51\fs20\qj Act) changed the way Medicare covers and pays for pharmaceutical products. The legislation expanded Medicare coverage for\plain\cf1\f51\fs20\qj drug purchases by the elderly and introduced a new reimbursement methodology based on average sales prices for\plain\cf1\f51\fs20\qj physician-administered drugs. In addition, this legislation provided authority for limiting the number of drugs that will be\plain\cf1\f51\fs20\qj covered in any therapeutic class. Cost reduction initiatives and other provisions of this legislation could decrease the coverage\plain\cf1\f51\fs20\qj and price that we receive for any approved products. While the Medicare Modernization Act applies only to drug benefits for\plain\cf1\f51\fs20\qj Medicare beneficiaries,
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qc 35
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\page
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\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj private payers often follow Medicare coverage policy and payment limitations in setting their own reimbursement rates.\plain\cf1\f51\fs20\qj Therefore, any reduction in reimbursement that results from the Medicare Modernization Act may result in a similar reduction in\plain\cf1\f51\fs20\qj payments from private payers.
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj More recently, in March 2010, the Health Care Reform Law was enacted to broaden access to health insurance, reduce or\plain\cf1\f51\fs20\qj constrain the growth of healthcare spending, enhance remedies against fraud and abuse, add new transparency requirements for\plain\cf1\f51\fs20\qj health care and health insurance industries, impose new taxes and fees on the health industry and impose additional health policy\plain\cf1\f51\fs20\qj reforms. The Health Care Reform Law revises the definition of \u8220?average manufacturer price\u8221? for reporting purposes,\plain\cf1\f51\fs20\qj which could increase the amount of Medicaid drug rebates to states. Further, the new law imposes a significant annual fee on\plain\cf1\f51\fs20\qj companies that manufacture or import branded prescription drug products. New provisions affecting compliance have also been\plain\cf1\f51\fs20\qj enacted, which may affect our business practices with health care practitioners. We will not know the full effects of the Health\plain\cf1\f51\fs20\qj Care Reform Law until applicable federal and state agencies issue regulations or guidance under the new law.
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj Although it is too early to determine the effect of the Health Care Reform Law, the new law appears likely to continue the\plain\cf1\f51\fs20\qj pressure on pharmaceutical pricing, especially under the Medicare program, and may also increase our regulatory burdens and\plain\cf1\f51\fs20\qj operating costs.
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj Legislative and regulatory proposals have been made to expand post-approval requirements and restrict sales and promotional\plain\cf1\f51\fs20\qj activities for pharmaceutical products. We are not sure whether additional legislative changes will be enacted, or whether the\plain\cf1\f51\fs20\qj FDA regulations, guidance or interpretations will be changed, or what the impact of such changes on the marketing approvals of\plain\cf1\f51\fs20\qj our product candidates, if any, may be.
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\b\qc Risks Related to Our Reliance on Third Parties\par\pard\plain\fi792\cf1\f51\fs20\qj \~\par\pard\plain\cf1\f51\fs20\b\i\qj We rely on third-party manufacturers to produce our preclinical and clinical drug supplies, and we intend to rely on third\plain\cf1\f51\fs20\b\i\qj parties to produce commercial supplies of any approved product candidates.*
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj We do not own or operate, and we do not expect to own or operate, facilities for product manufacturing, storage and distribution,\plain\cf1\f51\fs20\qj or testing. In the past, we have relied on third-party manufacturers for supply of our preclinical and clinical drug supplies. We\plain\cf1\f51\fs20\qj expect that in the future we will continue to rely on such manufacturers for drug supply that will be used in clinical trials of our\plain\cf1\f51\fs20\qj product candidates, including brincidofovir, and for commercialization of any of our product candidates that receive regulatory\plain\cf1\f51\fs20\qj approval.\par\pard\plain\cf1\f51\fs20\qj \~\par\pard\plain\cf1\f51\fs20\qj Our reliance on third-party manufacturers entails risks, including:\par\pard\plain\fi792\cf1\f51\fs20\qj \~
\par\pard\plain
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj inability to meet our product specifications and quality requirements\plain\intbl\cf1\f51\fs20\qj consistently;\cell{
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj delay or inability to procure or expand sufficient manufacturing\plain\intbl\cf1\f51\fs20\qj capacity;\cell{
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\pard\plain
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj manufacturing and product quality issues related to scale-up of\plain\intbl\cf1\f51\fs20\qj manufacturing;\cell{
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\pard\plain
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj costs and validation of new equipment and facilities required for\plain\intbl\cf1\f51\fs20\qj scale-up;\cell{
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\pard\plain
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj failure to comply with cGMP and similar foreign\plain\intbl\cf1\f51\fs20\qj standards;\cell{
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\pard\plain
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj inability to negotiate manufacturing agreements with third parties under commercially reasonable\plain\intbl\cf1\f51\fs20\qj terms;\cell{
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\pard\plain
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{\trowd\clvertalc\cellx1080\clvertalc\cellx10800\trrh-66\row}}}
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj termination or nonrenewal of manufacturing agreements with third parties in a manner or at a time that is costly or\plain\intbl\cf1\f51\fs20\qj damaging to us;\cell{
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\pard\plain
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\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx1080\clvertalc\cellx10800\trrh-66\row}}}
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj reliance on a limited number of sources, and in some cases, single sources for product components, such that if we\plain\intbl\cf1\f51\fs20\qj are unable to secure a sufficient supply of these product components, we will be unable to manufacture and sell our\plain\intbl\cf1\f51\fs20\qj product candidates in a timely fashion, in sufficient quantities or under acceptable terms;\cell{
{\trowd\cellx1080\cellx10800\trrh742\row}}}
\pard\plain
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj lack of qualified backup suppliers for those components that are currently purchased from a sole or single source\plain\intbl\cf1\f51\fs20\qj supplier;\cell{
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\pard\plain
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj operations of our third-party manufacturers or suppliers could be disrupted by conditions unrelated to our business\plain\intbl\cf1\f51\fs20\qj or operations, including the bankruptcy of the manufacturer or supplier;\cell{
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\pard\plain
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj carrier disruptions or increased costs that are beyond our\plain\intbl\cf1\f51\fs20\qj control; and\cell{
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\pard\plain
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\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj failure to deliver our products under specified storage conditions and in a timely\plain\intbl\cf1\f51\fs20\qj manner.\cell{
{\trowd\cellx970\cellx7954\trrh495\row}}}
\par\pard\plain\fs16\pard\plain\cf1\f51\fs20\qj Any of these events could lead to clinical study delays, failure to obtain regulatory approval or impact our ability to successfully\plain\cf1\f51\fs20\qj commercialize our products. Some of these events could be the basis for FDA action, including injunction, recall, seizure, or total\plain\cf1\f51\fs20\qj or partial suspension of production.\par\pard\plain\cf1\f51\fs20\qj \~
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qc 36
\par\pard\plain\fs16\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par
\page
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\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\b\i\qj We rely on limited sources of supply for the drug component for our lead product candidate, brincidofovir, and any disruption\plain\cf1\f51\fs20\b\i\qj in the chain of supply may cause delay in developing and commercializing brincidofovir.*\par\pard\plain\fi792\cf1\f51\fs20\qj \~\par\pard\plain\cf1\f51\fs20\qj Manufacturing of drug components is subject to certain FDA and comparable foreign qualifications with respect to manufacturing\plain\cf1\f51\fs20\qj standards. We are currently transferring the drug substance manufacturing process to our selected contractor that will produce the\plain\cf1\f51\fs20\qj commercial supply of drug substance and have selected a commercial tablet and suspension manufacturer to optimize tablet and\plain\cf1\f51\fs20\qj suspension formulation production to meet forecasted commercial demand. There can be no assurance that such transfer will be\plain\cf1\f51\fs20\qj successful. It is our expectation that only one supplier of drug substance and one supplier of drug product will be qualified as\plain\cf1\f51\fs20\qj vendors with the FDA. If supply from an approved vendor is interrupted, there could be a significant disruption in commercial\plain\cf1\f51\fs20\qj supply of brincidofovir. An alternative vendor would need to be qualified through an NDA supplement which could result in\plain\cf1\f51\fs20\qj further delay. The FDA or other regulatory agencies outside of the United States may also require additional studies if a new\plain\cf1\f51\fs20\qj drug substance or drug product supplier is relied upon for commercial production.
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj These factors could cause the delay of clinical trials, regulatory submissions, required approvals or commercialization of\plain\cf1\f51\fs20\qj brincidofovir, and cause us to incur additional costs. Furthermore, if our suppliers fail to deliver the required commercial\plain\cf1\f51\fs20\qj quantities of active pharmaceutical ingredient on a timely basis and at commercially reasonable prices, and we are unable to\plain\cf1\f51\fs20\qj secure one or more replacement suppliers capable of production at a substantially equivalent cost, our clinical trials for\plain\cf1\f51\fs20\qj brincidofovir may be delayed, which could inhibit our ability to generate revenues.\par\pard\plain\fi396\cf1\f51\fs20\qj \~\par\pard\plain\cf1\f51\fs20\b\i\qj Manufacturing issues may arise that could increase product and regulatory approval costs or delay commercialization of\plain\cf1\f51\fs20\b\i\qj brincidofovir.\par\pard\plain\fi792\cf1\f51\fs20\qj \~\par\pard\plain\cf1\f51\fs20\qj We have validated processes for drug substance and drug product production for brincidofovir at scales that are well in excess of\plain\cf1\f51\fs20\qj our anticipated commercial scale. We are currently revalidating our drug substance and drug product processes using our current\plain\cf1\f51\fs20\qj commercial processes at our intended commercial scale with our intended commercial manufacturers.
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj The validation processes, along with ongoing stability studies and analyses we are conducting, may reveal difficulties in our\plain\cf1\f51\fs20\qj processes which could require resolution in order to proceed with our planned clinical trials and obtain regulatory approval for\plain\cf1\f51\fs20\qj the commercial marketing of brincidofovir. In the future, we may identify significant impurities, which could result in increased\plain\cf1\f51\fs20\qj scrutiny by the regulatory agencies, delays in clinical program and regulatory approval for brincidofovir, increases in our\plain\cf1\f51\fs20\qj operating expenses, or failure to obtain or maintain approval for brincidofovir.
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\b\i\qj We depend on the continuation of our current collaboration with ContraVir Pharmaceuticals, who is currently responsible for\plain\cf1\f51\fs20\b\i\qj developing and commercializing CMX157.*
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj In December 2014, we entered into a licensing arrangement with ContraVir, whereby ContraVir is responsible for the future\plain\cf1\f51\fs20\qj development and commercialization of CMX157. Under this arrangement, ContraVir is responsible for conducting preclinical\plain\cf1\f51\fs20\qj studies and clinical trials, obtaining required regulatory approvals for CMX157, and manufacturing and commercializing\plain\cf1\f51\fs20\qj CMX157. Our right to receive milestone and royalty payments under the licensing agreement depends on the achievement of\plain\cf1\f51\fs20\qj certain development, regulatory and commercial milestones by ContraVir.
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj The development and commercialization of CMX157 and our ability to receive potential milestones and royalty payments under\plain\cf1\f51\fs20\qj the license agreement with ContraVir, would be adversely affected if ContraVir:
\par\pard\plain\fs16
\pard\plain
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj lacks or does not devote sufficient time and resources to the development and commercialization of\plain\intbl\cf1\f51\fs20\qj CMX157;\cell{
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\pard\plain
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj lacks or does not devote sufficient capital to fund the development and commercialization of\plain\intbl\cf1\f51\fs20\qj CMX157;\cell{
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\pard\plain
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj develops, either alone or with others, products that compete with\plain\intbl\cf1\f51\fs20\qj CMX157;\cell{
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj fails to gain the requisite regulatory approvals for\plain\intbl\cf1\f51\fs20\qj CMX157;\cell{
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\pard\plain
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj does not successfully commercialize\plain\intbl\cf1\f51\fs20\qj CMX157;\cell{
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\pard\plain
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj does not conduct its activities in a\plain\intbl\cf1\f51\fs20\qj timely manner;\cell{
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj terminates its license\plain\intbl\cf1\f51\fs20\qj with us;\cell{
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\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj does not effectively pursue and enforce intellectual property rights relating to\plain\intbl\cf1\f51\fs20\qj CMX157; or\cell{
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\pard\plain
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\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj merges with a third-party that wants to terminate the\plain\intbl\cf1\f51\fs20\qj collaboration.\cell{
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\par\pard\plain\fs16\pard\plain\cf1\f51\fs20\qj We have limited or no control over the occurrence of any of the foregoing. Furthermore, disagreements with ContraVir could\plain\cf1\f51\fs20\qj lead to litigation or arbitration, which could be time-consuming and expensive. If any of these issues arise, it may delay the\plain\cf1\f51\fs20\qj development and commercialization milestones and royalties based on further development and sales of CMX157.
\par\pard\plain\fs16
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qc 37
\par\pard\plain\fs16\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par
\page
\par\pard\plain\fs16
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\b\i\qj We rely on third parties to conduct, supervise and monitor our clinical studies and related data, and if those third parties\plain\cf1\f51\fs20\b\i\qj perform in an unsatisfactory manner, it may harm our business.\par\pard\plain\cf1\f51\fs20\qj \~\par\pard\plain\cf1\f51\fs20\qj We rely on CROs and clinical trial sites to ensure the proper and timely conduct of our clinical trials. While we have agreements\plain\cf1\f51\fs20\qj governing their activities, we have limited influence over their actual performance. We have relied and plan to continue to rely\plain\cf1\f51\fs20\qj upon CROs to monitor and manage data for our ongoing clinical programs for brincidofovir and our other product candidates, as\plain\cf1\f51\fs20\qj well as the execution of nonclinical studies. We control only certain aspects of our CROs\u8217? activities. Nevertheless, we are\plain\cf1\f51\fs20\qj responsible for ensuring that each of our studies is conducted in accordance with the applicable protocol, legal, regulatory and\plain\cf1\f51\fs20\qj scientific standards and our reliance on CROs does not relieve us of our regulatory responsibilities.
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj We and our CROs are required to comply with the FDA\u8217?s guidance, which follows the International Conference on\plain\cf1\f51\fs20\qj Harmonization Good Clinical Practice (ICH GCP), which are regulations and guidelines enforced by the FDA for all of our\plain\cf1\f51\fs20\qj product candidates in clinical development. The FDA enforces the ICH GCP through periodic inspections of trial sponsors,\plain\cf1\f51\fs20\qj principal investigators and clinical trial sites. If we or our CROs fail to comply with the ICH GCP, the clinical data generated in\plain\cf1\f51\fs20\qj our clinical trials may be deemed unreliable and the FDA may require us to perform additional clinical trials before approving\plain\cf1\f51\fs20\qj our marketing applications. For example, upon inspection, the FDA may determine that our Phase 3 clinical trial for\plain\cf1\f51\fs20\qj brincidofovir, SUPPRESS, does not comply with the ICH GCP. In addition, our Phase 3 clinical trials for brincidofovir will\plain\cf1\f51\fs20\qj require a sufficiently large number of test subjects to evaluate the safety and effectiveness of brincidofovir. Accordingly, if our\plain\cf1\f51\fs20\qj CROs fail to comply with these regulations or fail to recruit a sufficient number of subjects, we may be required to repeat these\plain\cf1\f51\fs20\qj Phase 3 clinical trials, which would delay the regulatory approval process.
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj Our CROs are not our employees, and we cannot control whether or not they devote sufficient time and resources to our ongoing\plain\cf1\f51\fs20\qj clinical and nonclinical programs. These CROs may also have relationships with other commercial entities, including our\plain\cf1\f51\fs20\qj competitors, for whom they may also be conducting clinical studies, or other drug development activities which could harm our\plain\cf1\f51\fs20\qj competitive position. We face the risk of potential unauthorized disclosure or misappropriation of our intellectual property by\plain\cf1\f51\fs20\qj CROs, which may reduce our trade secret protection and allow our potential competitors to access and exploit our proprietary\plain\cf1\f51\fs20\qj technology.
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj If our CROs do not successfully carry out their contractual duties or obligations, fail to meet expected deadlines, or if the quality\plain\cf1\f51\fs20\qj or accuracy of the clinical data they obtain is compromised due to the failure to adhere to our clinical protocols or regulatory\plain\cf1\f51\fs20\qj requirements or for any other reasons, our clinical trials may be extended, delayed or terminated, and we may not be able to\plain\cf1\f51\fs20\qj obtain regulatory approval for, or successfully commercialize brincidofovir or our other product candidates. Disagreements with\plain\cf1\f51\fs20\qj our CROs over contractual issues, including performance, compliance or compensation could lead to termination of CRO\plain\cf1\f51\fs20\qj agreements and/or delays in our clinical program and risks to the accuracy and usability of clinical data. As a result, our financial\plain\cf1\f51\fs20\qj results and the commercial prospects for brincidofovir and any other product candidates that we develop would be harmed, our\plain\cf1\f51\fs20\qj costs could increase, and our ability to generate revenues could be delayed.
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\b\qc Risks Related to Commercialization of Our Product Candidates\par\pard\plain\fi792\cf1\f51\fs20\qj \~\par\pard\plain\cf1\f51\fs20\b\i\qj The commercial success of brincidofovir and our other product candidates will depend upon the acceptance of these products\plain\cf1\f51\fs20\b\i\qj by the medical community, including physicians, patients, pharmacists and health care payers.\par\pard\plain\fi792\cf1\f51\fs20\qj \~\par\pard\plain\cf1\f51\fs20\qj If any of our product candidates, including brincidofovir, receive marketing approval, they may nonetheless not gain sufficient\plain\cf1\f51\fs20\qj market acceptance by physicians, patients, healthcare payers and others in the medical community. If these products do not\plain\cf1\f51\fs20\qj achieve an adequate level of market acceptance, we may not generate significant product revenues and we may not become\plain\cf1\f51\fs20\qj profitable. The degree of market acceptance of any of our product candidates, including brincidofovir, will depend on a number\plain\cf1\f51\fs20\qj of factors, including:\par\pard\plain\fi924\cf1\f51\fs20\qj \~
\par\pard\plain
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj demonstration of clinical safety and efficacy in our\plain\intbl\cf1\f51\fs20\qj clinical trials;\cell{
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj relative convenience, ease of administration and acceptance by physicians, patients, pharmacists and health care\plain\intbl\cf1\f51\fs20\qj payers;\cell{
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj prevalence and severity of\plain\intbl\cf1\f51\fs20\qj any AEs;\cell{
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj limitations or warnings contained in the FDA-approved label for the relevant product\plain\intbl\cf1\f51\fs20\qj candidate;\cell{
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj availability of alternative\plain\intbl\cf1\f51\fs20\qj treatments;\cell{
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj pricing and\plain\intbl\cf1\f51\fs20\qj cost-effectiveness;\cell{
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj effectiveness of our or any future collaborators\u8217? sales and marketing\plain\intbl\cf1\f51\fs20\qj strategies;\cell{
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj ability to ensure availability for product through appropriate\plain\intbl\cf1\f51\fs20\qj channels;\cell{
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj ability to maintain adequate\plain\intbl\cf1\f51\fs20\qj inventory; and\cell{
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\par\pard\plain\fs16\pard\plain\cf1\f51\fs20\qc 38
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj ability to obtain and maintain sufficient third-party coverage or reimbursement, which may vary from country to\plain\intbl\cf1\f51\fs20\qj country.\cell{
{\trowd\cellx1080\cellx10800\trrh495\row}}}
\par\pard\plain\fs16\pard\plain\cf1\f51\fs20\b\i\qj If we are unable to establish sales and marketing capabilities or enter into agreements with third parties to market and sell\plain\cf1\f51\fs20\b\i\qj our product candidates, we may be unable to generate any revenue.*\par\pard\plain\fi792\cf1\f51\fs20\qj \~\par\pard\plain\cf1\f51\fs20\qj We currently do not have an organization for the sales and distribution of pharmaceutical products. The cost of establishing and\plain\cf1\f51\fs20\qj maintaining such an organization may exceed the cost-effectiveness of doing so. In order to market any products that may be\plain\cf1\f51\fs20\qj approved, including brincidofovir, we must establish our sales, marketing, managerial and other non-technical capabilities or\plain\cf1\f51\fs20\qj make arrangements with third parties to perform these services. We may enter into strategic partnerships with third parties to\plain\cf1\f51\fs20\qj commercialize our product candidates outside of the United States, including for brincidofovir. We intend to build our own sales\plain\cf1\f51\fs20\qj force and to commercialize brincidofovir in the United States, but we will also consider the option to enter into strategic\plain\cf1\f51\fs20\qj partnerships for our product candidates in the United States and elsewhere.
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj Our strategy for brincidofovir is to establish a specialty sales force and/or collaborate with third parties to promote the product to\plain\cf1\f51\fs20\qj healthcare professionals and third-party payers in the United States and elsewhere. We may elect to launch with a contract sales\plain\cf1\f51\fs20\qj organization and utilize accompanying commercial support services provided by a contract sales organization. Our future\plain\cf1\f51\fs20\qj collaboration partners, if any, may not dedicate sufficient resources to the commercialization of our product candidates or may\plain\cf1\f51\fs20\qj otherwise fail in their commercialization due to factors beyond our control. If we are unable to establish effective collaborations\plain\cf1\f51\fs20\qj to enable the sale of our product candidates to healthcare professionals and in geographical regions, including the United States,\plain\cf1\f51\fs20\qj that are not covered by our own marketing and sales force, or if our potential future collaboration partners do not successfully\plain\cf1\f51\fs20\qj commercialize our product candidates, our ability to generate revenues from product sales, including sales of brincidofovir, will\plain\cf1\f51\fs20\qj be adversely affected.
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj Establishing an internal sales force involves many challenges, including:\par\pard\plain\fi792\cf1\f51\fs20\qj \~
\par\pard\plain
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj recruiting and retaining\plain\intbl\cf1\f51\fs20\qj talented people;\cell{
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj training employees that we\plain\intbl\cf1\f51\fs20\qj recruit;\cell{
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj establishing compliance\plain\intbl\cf1\f51\fs20\qj standards;\cell{
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\pard\plain
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj setting the appropriate system of\plain\intbl\cf1\f51\fs20\qj incentives;\cell{
{\trowd\cellx791\cellx3696\trrh495\row}}}
\pard\plain
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj managing additional\plain\intbl\cf1\f51\fs20\qj headcount;\cell{
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\pard\plain
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj ensuring that appropriate support functions are in place to support sales force organizational needs;\plain\intbl\cf1\f51\fs20\qj and\cell{
{\trowd\cellx1021\cellx9548\trrh495\row}}}
\pard\plain
{\trowd\clvertalc\cellx891\clvertalc\cellx5976\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx891\clvertalc\cellx5976\trrh-66\row}}}
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj integrating a new business unit into an existing corporate\plain\intbl\cf1\f51\fs20\qj architecture.\cell{
{\trowd\cellx891\cellx5976\trrh495\row}}}
\par\pard\plain\fs16\pard\plain\cf1\f51\fs20\qj If we are unable to establish our own sales force or negotiate a strategic partnership for the commercialization of brincidofovir in\plain\cf1\f51\fs20\qj any markets, we may be forced to delay the potential commercialization of brincidofovir in those markets, reduce the scope of\plain\cf1\f51\fs20\qj our sales or marketing activities for brincidofovir in those markets or undertake the commercialization activities for brincidofovir\plain\cf1\f51\fs20\qj in those markets at our own expense. If we elect to increase our expenditures to fund commercialization activities ourselves, we\plain\cf1\f51\fs20\qj will need to obtain additional capital, which may not be available to us on acceptable terms, or at all. If we do not have\plain\cf1\f51\fs20\qj sufficient funds, we will not be able to bring brincidofovir to market or generate product revenue. Limited or lack of funding will\plain\cf1\f51\fs20\qj impede our ability to achieve successful commercialization.
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj If we are unable to establish adequate sales, marketing and distribution capabilities, whether independently or with third parties,\plain\cf1\f51\fs20\qj we may not be able to generate sufficient product revenue and may not become profitable. We will be competing with many\plain\cf1\f51\fs20\qj companies that currently have extensive and well-funded marketing and sales operations. Without an internal team or the support\plain\cf1\f51\fs20\qj of a third party to perform marketing and sales functions, we may be unable to compete successfully against these more\plain\cf1\f51\fs20\qj established companies.
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj In addition, there are risks involved with both establishing our own sales and marketing capabilities and entering into\plain\cf1\f51\fs20\qj arrangements with third parties to perform these services. For example, recruiting and training a sales force is expensive and\plain\cf1\f51\fs20\qj time-consuming and could delay any product launch. If the commercial launch of a product candidate for which we recruit a\plain\cf1\f51\fs20\qj sales force and establish marketing capabilities is delayed or does not occur for any reason, we would have prematurely or\plain\cf1\f51\fs20\qj unnecessarily incurred these commercialization expenses. This may be costly, and our investment would be lost if we cannot\plain\cf1\f51\fs20\qj retain or reposition our sales, marketing and market access personnel.\par\pard\plain\cf1\f51\fs20\qj \~
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qc 39
\par\pard\plain\fs16\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par
\page
\par\pard\plain\fs16
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\b\i\qj If we obtain approval to commercialize any products outside of the United States, a variety of risks associated with\plain\cf1\f51\fs20\b\i\qj international operations could materially adversely affect our business.\par\pard\plain\fi792\cf1\f51\fs20\b\i\qj \~\par\pard\plain\cf1\f51\fs20\qj If our product candidates are approved for commercialization, we may enter into agreements with third parties to market those\plain\cf1\f51\fs20\qj product candidates outside the United States, including for brincidofovir. We expect that we will be subject to additional risks\plain\cf1\f51\fs20\qj related to entering into international business relationships, including:\par\pard\plain\fi792\cf1\f51\fs20\qj \~
\par\pard\plain
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj different regulatory requirements for drug approvals in foreign\plain\intbl\cf1\f51\fs20\qj countries;\cell{
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\pard\plain
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj reduced protection for intellectual\plain\intbl\cf1\f51\fs20\qj property rights;\cell{
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\pard\plain
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj unexpected changes in tariffs, trade barriers and regulatory and labor\plain\intbl\cf1\f51\fs20\qj requirements;\cell{
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\pard\plain
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj economic weakness, including inflation, or political instability in particular foreign economies and\plain\intbl\cf1\f51\fs20\qj markets;\cell{
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\pard\plain
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj compliance with tax, employment, immigration and labor laws for employees living or traveling\plain\intbl\cf1\f51\fs20\qj abroad;\cell{
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\pard\plain
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj foreign taxes, including withholding of\plain\intbl\cf1\f51\fs20\qj payroll taxes;\cell{
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\pard\plain
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj foreign currency fluctuations, which could result in increased operating expenses and reduced revenues, and other\plain\intbl\cf1\f51\fs20\qj obligations incident to doing business in another country;\cell{
{\trowd\cellx1080\cellx10800\trrh495\row}}}
\pard\plain
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj workforce uncertainty in countries where labor unrest is more common than in the United\plain\intbl\cf1\f51\fs20\qj States;\cell{
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\pard\plain
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj production shortages resulting from any events affecting raw material supply or manufacturing capabilities abroad;\plain\intbl\cf1\f51\fs20\qj and\cell{
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\pard\plain
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj business interruptions resulting from geopolitical actions, including war and terrorism, or natural disasters including\plain\intbl\cf1\f51\fs20\qj earthquakes, typhoons, floods and fires.\cell{
{\trowd\cellx1080\cellx10800\trrh495\row}}}
\par\pard\plain\fs16\pard\plain\cf1\f51\fs20\qj We have limited experience in these areas. In addition, there are complex regulatory, tax, labor and other legal requirements\plain\cf1\f51\fs20\qj imposed by both the European Union and many of the individual countries in Europe with which we will need to comply. Many\plain\cf1\f51\fs20\qj U.S.-based biopharmaceutical companies have found the process of marketing their own products outside the United States to be\plain\cf1\f51\fs20\qj very challenging.\par\pard\plain\fi792\cf1\f51\fs20\qj \~\par\pard\plain\cf1\f51\fs20\b\i\qj We face significant competition from other biotechnology and pharmaceutical companies and our operating results will suffer\plain\cf1\f51\fs20\b\i\qj if we fail to compete effectively.*\par\pard\plain\fi792\cf1\f51\fs20\qj \~\par\pard\plain\cf1\f51\fs20\qj The biotechnology and pharmaceutical industries are intensely competitive. We have competitors both in the United States and\plain\cf1\f51\fs20\qj internationally, including major multinational pharmaceutical companies, biotechnology companies and universities and other\plain\cf1\f51\fs20\qj research institutions.
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj Currently the only approved antiviral treatment for CMV infections in HCT patients is Cytovene\u174? (ganciclovir), although\plain\cf1\f51\fs20\qj other antivirals, such as Valcyte\u174? (valganciclovir), Foscavir\u174? (foscarnet), Zovirax\u174? (acyclovir) and Vistide\u174?\plain\cf1\f51\fs20\qj (cidofovir) are used. Ganciclovir, foscarnet, cidofovir, and valganciclovir are currently generically available. We are aware of\plain\cf1\f51\fs20\qj several companies that are working specifically to develop drugs that would compete against brincidofovir for the prevention or\plain\cf1\f51\fs20\qj treatment of CMV, including Merck & Co., Inc.\u8217?s development of letermovir, Shire Plc's development of maribavir, and\plain\cf1\f51\fs20\qj Vical Incorporated\u8217?s and Astellas Pharma US, Inc.\u8217?s development of ASP0113 (TransVax), and the additional\plain\cf1\f51\fs20\qj availability of patient-specific T-cell therapies targeting antigens for CMV and other dsDNA viruses. Many of our competitors\plain\cf1\f51\fs20\qj have substantially greater financial, technical, commercial and other resources, such as larger research and development staff,\plain\cf1\f51\fs20\qj stronger intellectual property portfolios and experienced marketing and manufacturing organizations. Additional mergers and\plain\cf1\f51\fs20\qj acquisitions in the biotechnology and pharmaceutical industries may result in even more resources being concentrated in our\plain\cf1\f51\fs20\qj competitors.
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj Competition may increase further as a result of advances in the commercial applicability of technologies and greater availability\plain\cf1\f51\fs20\qj of capital for investment in these industries. Our competitors may succeed in developing, acquiring or licensing, on an exclusive\plain\cf1\f51\fs20\qj basis, drug products that are more effective or less costly than brincidofovir or any other drug candidate that we are currently\plain\cf1\f51\fs20\qj developing or that we may develop.
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj We will face competition from other drugs currently approved or that will be approved in the future for the same indications.\plain\cf1\f51\fs20\qj Therefore, our ability to compete successfully will depend largely on our ability to:\~\~
\par\pard\plain\fs16
\pard\plain
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\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj discover and develop medicines that are superior to other products in the\plain\intbl\cf1\f51\fs20\qj market;\cell{
{\trowd\cellx939\cellx7076\trrh495\row}}}
\pard\plain
{\trowd\clvertalc\cellx1080\clvertalc\cellx10800\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx1080\clvertalc\cellx10800\trrh-66\row}}}
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj demonstrate through our clinical trials that our product candidates, including brincidofovir, are differentiated from\plain\intbl\cf1\f51\fs20\qj existing and future therapies;\cell{
{\trowd\cellx1080\cellx10800\trrh495\row}}}
\pard\plain
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\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx890\clvertalc\cellx6058\trrh-66\row}}}
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj evaluate new potential indications across the lifecycle of\plain\intbl\cf1\f51\fs20\qj brincidofovir;\cell{
{\trowd\cellx890\cellx6058\trrh495\row}}}
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj attract qualified scientific, product development and commercial\plain\intbl\cf1\f51\fs20\qj personnel;\cell{
{\trowd\cellx907\cellx6408\trrh495\row}}}
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj obtain and successfully defend and enforce patent and/or other proprietary protection for our medicines and\plain\intbl\cf1\f51\fs20\qj technologies;\cell{
{\trowd\cellx1080\cellx10800\trrh495\row}}}
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj obtain required regulatory\plain\intbl\cf1\f51\fs20\qj approvals;\cell{
{\trowd\cellx764\cellx3129\trrh495\row}}}
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj successfully collaborate with pharmaceutical companies in the discovery, development and commercialization of new\plain\intbl\cf1\f51\fs20\qj medicines; and\cell{
{\trowd\cellx1080\cellx10800\trrh495\row}}}
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj negotiate competitive pricing and reimbursement with\plain\intbl\cf1\f51\fs20\qj third-party payers.\cell{
{\trowd\cellx897\cellx6299\trrh495\row}}}
\par\pard\plain\fs16\pard\plain\cf1\f51\fs20\qj The availability of our competitors\u8217? products could limit the demand, and the price we are able to charge, for brincidofovir\plain\cf1\f51\fs20\qj and any other product candidate we develop. We will not achieve our business plan if the acceptance of brincidofovir is inhibited\plain\cf1\f51\fs20\qj by price competition or reimbursement issues or the reluctance of physicians to switch from existing drug products to\plain\cf1\f51\fs20\qj brincidofovir, or if physicians switch to other new drug products or choose to reserve brincidofovir for use in limited\plain\cf1\f51\fs20\qj circumstances. The inability to compete with existing or subsequently introduced drug products would have a material adverse\plain\cf1\f51\fs20\qj impact on our business, financial condition and prospects.\par\pard\plain\fi792\cf1\f51\fs20\qj \~\par\pard\plain\cf1\f51\fs20\qj Established pharmaceutical companies may invest heavily to accelerate discovery and development of novel compounds or to\plain\cf1\f51\fs20\qj in-license novel compounds that could make our product candidates, including brincidofovir, less competitive. In addition, any\plain\cf1\f51\fs20\qj new product that competes with an approved product must demonstrate compelling advantages in efficacy, convenience,\plain\cf1\f51\fs20\qj tolerability and safety in order to overcome price competition and to be commercially successful. Accordingly, our competitors\plain\cf1\f51\fs20\qj may succeed in obtaining patent protection, receiving FDA approval or discovering, developing and commercializing medicines\plain\cf1\f51\fs20\qj before we do, which would have a material adverse impact on our business.
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj New technologies or procedures could be developed that would change or restrict the number of patients undergoing\plain\cf1\f51\fs20\qj hematopoietic cell or solid organ transplants. A reduction in the number of transplants could negatively impact our commercial\plain\cf1\f51\fs20\qj business by decreasing sales of our products and limiting peak sales potential.\par\pard\plain\cf1\f51\fs20\qj \~\par\pard\plain\cf1\f51\fs20\b\i\qj Hospital formulary approval and reimbursement may not be available for brincidofovir and our other product candidates,\plain\cf1\f51\fs20\b\i\qj which could make it difficult for us to sell our products profitably.\par\pard\plain\fi792\cf1\f51\fs20\qj \~\par\pard\plain\cf1\f51\fs20\qj Obtaining hospital formulary approval can be an expensive and time consuming process. We cannot be certain if and when we\plain\cf1\f51\fs20\qj will obtain formulary approval to allow us to sell our product candidates, including brincidofovir, into our target markets. Failure\plain\cf1\f51\fs20\qj to obtain timely formulary approval will limit our commercial success.
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj Furthermore, market acceptance and sales of brincidofovir, or any other product candidates that we develop, will depend in part\plain\cf1\f51\fs20\qj on the extent to which reimbursement for these products and related treatments will be available from government health\plain\cf1\f51\fs20\qj administration authorities, private health insurers and other organizations. Government authorities and third-party payers, such as\plain\cf1\f51\fs20\qj private health insurers, hospitals and health maintenance organizations, decide which drugs they will pay for and establish\plain\cf1\f51\fs20\qj reimbursement levels. A primary trend in the U.S. healthcare industry and elsewhere is cost containment. Government authorities\plain\cf1\f51\fs20\qj and these third-party payers have attempted to control costs by limiting coverage and the amount of reimbursement for particular\plain\cf1\f51\fs20\qj medications. Obtaining reimbursement for our products may be particularly difficult because of the higher prices often associated\plain\cf1\f51\fs20\qj with products administered under the supervision of a physician. We cannot be sure that reimbursement will be available for\plain\cf1\f51\fs20\qj brincidofovir, or any other product candidates.
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj Also, reimbursement amounts may reduce the demand for, or the price of, our products. If reimbursement is not available, or is\plain\cf1\f51\fs20\qj available only to limited levels, we may not be able to successfully commercialize brincidofovir, or any other product candidates\plain\cf1\f51\fs20\qj that we develop.
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj There have been a number of legislative and regulatory proposals to change the healthcare system in the United States and in\plain\cf1\f51\fs20\qj some foreign jurisdictions that could affect our ability to sell any future products profitably. These legislative and regulatory\plain\cf1\f51\fs20\qj changes may negatively impact the reimbursement for any future products, following approval. The availability of generic\plain\cf1\f51\fs20\qj treatments may also substantially reduce the likelihood of reimbursement for any future products, including brincidofovir. The\plain\cf1\f51\fs20\qj application of user fees to generic drug products will likely expedite the approval of additional generic drug treatments. We\plain\cf1\f51\fs20\qj expect to experience pricing pressures in connection with the sale of brincidofovir and any other product candidate that we\plain\cf1\f51\fs20\qj develop, due to the trend toward managed healthcare, the increasing influence of health maintenance organizations and additional\plain\cf1\f51\fs20\qj legislative changes. In addition, there may be significant delays in obtaining reimbursement for approved products, and coverage\plain\cf1\f51\fs20\qj may be more limited than the purposes for which the product is approved by the FDA or regulatory authorities in other countries.\plain\cf1\f51\fs20\qj Moreover, eligibility for reimbursement does not imply that any product will be paid for in all cases or at a rate that covers our\plain\cf1\f51\fs20\qj costs, including research, development, manufacture, sale and distribution. Interim payments for new products, if applicable, may\plain\cf1\f51\fs20\qj also not be sufficient to cover our costs and may not be made permanent. Payment rates may vary according to the use of the\plain\cf1\f51\fs20\qj product and the clinical setting in which it is used, may be based on payments allowed for lower cost products that are already\plain\cf1\f51\fs20\qj reimbursed, and may be incorporated into existing payments for other services. Net prices for products may be reduced by\plain\cf1\f51\fs20\qj mandatory discounts or rebates required by government healthcare programs or private payers and by any future relaxation of\plain\cf1\f51\fs20\qj laws that presently restrict imports
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\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj of products from countries where they may be sold at lower prices than in the United States. Third-party payers often rely upon\plain\cf1\f51\fs20\qj Medicare coverage policy and payment limitations in setting their own reimbursement policies.
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj Our inability to promptly obtain coverage and profitable payment rates from both government funded and private payers for any\plain\cf1\f51\fs20\qj of our product candidates, including brincidofovir, could have a material adverse effect on our operating results, our ability to\plain\cf1\f51\fs20\qj raise capital needed to commercialize products and our overall financial condition.\par\pard\plain\fi792\cf1\f51\fs20\qj \~\par\pard\plain\cf1\f51\fs20\b\i\qj We may expend our limited resources to pursue a particular product candidate or indication and fail to capitalize on product\plain\cf1\f51\fs20\b\i\qj candidates or indications that may be more profitable or for which there is a greater likelihood of success.\par\pard\plain\fi792\cf1\f51\fs20\qj \~\par\pard\plain\cf1\f51\fs20\qj The success of our business depends primarily upon our ability to identify, develop and commercialize product candidates.\plain\cf1\f51\fs20\qj Because we have limited financial and managerial resources, we focus on research programs and product candidates for specific\plain\cf1\f51\fs20\qj indications. As a result, we may forego or delay pursuit of opportunities with other product candidates or other indications that\plain\cf1\f51\fs20\qj later prove to have greater commercial potential.
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj Our research programs may initially show promise in identifying potential product candidates, yet fail to yield product candidates\plain\cf1\f51\fs20\qj for clinical development for a number of reasons, including:\par\pard\plain\fi792\cf1\f51\fs20\qj \~
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj our research methodology or that of our collaboration partners may be unsuccessful in identifying potential product\plain\intbl\cf1\f51\fs20\qj candidates;\cell{
{\trowd\cellx1080\cellx10800\trrh495\row}}}
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj our potential product candidates may be shown to have harmful side effects or may have other characteristics that\plain\intbl\cf1\f51\fs20\qj may make the products unmarketable or unlikely to receive marketing approval; and\cell{
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj our collaboration partners may change their development profiles for potential product candidates or abandon a\plain\intbl\cf1\f51\fs20\qj therapeutic area.\cell{
{\trowd\cellx1080\cellx10800\trrh495\row}}}
\par\pard\plain\fs16\pard\plain\cf1\f51\fs20\qj If any of these events occur, we may be forced to abandon our development efforts for a program or programs, which would\plain\cf1\f51\fs20\qj have a material adverse effect on our business and could potentially cause us to cease operations. Research programs to identify\plain\cf1\f51\fs20\qj new product candidates require substantial technical, financial and human resources. We may focus our research efforts and\plain\cf1\f51\fs20\qj resources on potential programs or product candidates that ultimately prove to be unsuccessful.
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\ql If we do not accurately evaluate the commercial potential or target market for a particular product candidate, we may relinquish\plain\cf1\f51\fs20\ql valuable rights to that product candidate through collaboration, licensing or other royalty arrangements in cases in which it would\plain\cf1\f51\fs20\ql have been advantageous for us to retain sole development and commercialization rights.\par\pard\plain\cf1\f51\fs20\qj \~\par\pard\plain\cf1\f51\fs20\b\qc Risks Related to Our Intellectual Property\par\pard\plain\fi792\cf1\f51\fs20\qj \~\par\pard\plain\cf1\f51\fs20\b\i\qj If we are unable to obtain or protect intellectual property rights related to our products and product candidates, we may not\plain\cf1\f51\fs20\b\i\qj be able to compete effectively in our market.\par\pard\plain\fi792\cf1\f51\fs20\qj \~\par\pard\plain\cf1\f51\fs20\qj We rely upon a combination of patents, trade secret protection and confidentiality agreements to protect the intellectual property\plain\cf1\f51\fs20\qj related to our products and product candidates. The strength of patents in the biotechnology and pharmaceutical field involves\plain\cf1\f51\fs20\qj complex legal and scientific questions and can be uncertain. The patent applications that we own or in-license may fail to result\plain\cf1\f51\fs20\qj in issued patents with claims that cover the products in the United States or in other countries. If this were to occur, early generic\plain\cf1\f51\fs20\qj competition could be expected against brincidofovir and any other product candidates in development. There is no assurance that\plain\cf1\f51\fs20\qj all of the potentially relevant prior art relating to our patents and patent applications has been found, which can invalidate a\plain\cf1\f51\fs20\qj patent or prevent a patent from issuing based on a pending patent application. Even if patents do successfully issue, third parties\plain\cf1\f51\fs20\qj may challenge their validity, enforceability, scope or ownership, which may result in such patents, or our rights to such patents,\plain\cf1\f51\fs20\qj being narrowed or invalidated.
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj Furthermore, even if they are unchallenged, our patents and patent applications may not adequately protect our intellectual\plain\cf1\f51\fs20\qj property or prevent others from designing around our claims. If the patent applications we hold or license with respect to\plain\cf1\f51\fs20\qj brincidofovir fail to issue or if their breadth or strength of protection is threatened, it could dissuade companies from\plain\cf1\f51\fs20\qj collaborating with us to develop, and threaten our ability to commercialize, our products. We cannot offer any assurances about\plain\cf1\f51\fs20\qj which, if any, patents will issue or whether any issued patents will be found not invalid and not unenforceable, will go\plain\cf1\f51\fs20\qj unthreatened by third parties or will adequately protect our products and product candidates. Further, if we encounter delays in\plain\cf1\f51\fs20\qj regulatory approvals, the period of time during which we could market brincidofovir under patent protection could be reduced.\plain\cf1\f51\fs20\qj Since patent applications in the United States and most other countries are confidential for a period of time after filing, and some\plain\cf1\f51\fs20\qj remain so until issued, we cannot be certain that we or our licensors were the first to file any patent application related to\plain\cf1\f51\fs20\qj brincidofovir or our other product candidates. Furthermore, if third parties have filed such patent applications, an interference\plain\cf1\f51\fs20\qj proceeding in the United States can be provoked by a third party
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\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj or instituted by us to determine who was the first to invent any of the subject matter covered by the patent claims of our\plain\cf1\f51\fs20\qj applications. An unfavorable outcome could require us to cease using the related technology or to attempt to license it from the\plain\cf1\f51\fs20\qj prevailing party, which may not be possible. In addition to the protection afforded by patents, we rely on trade secret protection\plain\cf1\f51\fs20\qj and confidentiality agreements to protect proprietary know-how that is not patentable, processes for which patents are difficult to\plain\cf1\f51\fs20\qj enforce and other elements of our drug discovery and development processes that involve proprietary know-how, information or\plain\cf1\f51\fs20\qj technology that is not covered by patents. Although we expect all of our employees to assign their inventions to us, and all of\plain\cf1\f51\fs20\qj our employees, consultants, advisors and any third parties who have access to our proprietary know-how, information or\plain\cf1\f51\fs20\qj technology to enter into confidentiality agreements, we cannot provide any assurances that all such agreements have been duly\plain\cf1\f51\fs20\qj executed, that such agreements provide adequate protection and will not be breached, that our trade secrets and other confidential\plain\cf1\f51\fs20\qj proprietary information will not otherwise be disclosed or that competitors will not otherwise gain access to our trade secrets or\plain\cf1\f51\fs20\qj independently develop substantially equivalent information and techniques. If we are unable to prevent material disclosure of the\plain\cf1\f51\fs20\qj non-patented intellectual property related to our technologies to third parties, and there is no guarantee that we will have any\plain\cf1\f51\fs20\qj such enforceable trade secret protection, we may not be able to establish or maintain a competitive advantage in our market,\plain\cf1\f51\fs20\qj which could materially adversely affect our business, results of operations and financial condition.
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj Further, the laws of some foreign countries do not protect patents and other proprietary rights to the same extent or in the same\plain\cf1\f51\fs20\qj manner as the laws of the United States. As a result, we may encounter significant problems in protecting and defending our\plain\cf1\f51\fs20\qj intellectual property abroad. We may also fail to pursue or obtain patents and other intellectual property protection relating to our\plain\cf1\f51\fs20\qj products and product candidates in all foreign countries.
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj Finally, certain of our activities and our licensors\u8217? activities have been funded, and may in the future be funded, by the\plain\cf1\f51\fs20\qj U.S. federal government. When new technologies are developed with U.S. federal government funding, the government obtains\plain\cf1\f51\fs20\qj certain rights in any resulting patents, including a nonexclusive license authorizing the government to use the invention for\plain\cf1\f51\fs20\qj non-commercial purposes. These rights may permit the government to disclose our confidential information to third parties and\plain\cf1\f51\fs20\qj to exercise \u8220?march-in\u8221? rights to use or allow third parties to use our patented technology. The government can\plain\cf1\f51\fs20\qj exercise its march-in rights if it determines that action is necessary because we fail to achieve practical application of the U.S.\plain\cf1\f51\fs20\qj government-funded technology, because action is necessary to alleviate health or safety needs, to meet requirements of federal\plain\cf1\f51\fs20\qj regulations or to give preference to U.S. industry. In addition, U.S. government-funded inventions must be reported to the\plain\cf1\f51\fs20\qj government, U.S. government funding must be disclosed in any resulting patent applications, and our rights in such inventions\plain\cf1\f51\fs20\qj may be subject to certain requirements to manufacture products in the United States.\par\pard\plain\fi792\cf1\f51\fs20\b\i\qj \~\par\pard\plain\cf1\f51\fs20\b\i\qj Third-party claims of intellectual property infringement may prevent or delay our development and commercialization efforts\plain\cf1\f51\fs20\b\i\qj or otherwise affect our business.\par\pard\plain\fi792\cf1\f51\fs20\qj \~\par\pard\plain\cf1\f51\fs20\qj Our commercial success depends in part on our avoiding infringement and other violations of the patents and proprietary rights of\plain\cf1\f51\fs20\qj third parties. There is a substantial amount of litigation, both within and outside the United States, involving patent and other\plain\cf1\f51\fs20\qj intellectual property rights in the biotechnology and pharmaceutical industries, including patent infringement lawsuits,\plain\cf1\f51\fs20\qj interferences, oppositions and inter party reexamination proceedings before the United States Patent and Trademark Office (U.S.\plain\cf1\f51\fs20\qj PTO) and its foreign counterparts. Numerous U.S. and foreign issued patents and pending patent applications, which are owned\plain\cf1\f51\fs20\qj by third parties, exist in the fields in which we and our collaborators are developing product candidates. As the biotechnology\plain\cf1\f51\fs20\qj and pharmaceutical industries expand and more patents are issued, and as we gain greater visibility and market exposure as a\plain\cf1\f51\fs20\qj public company, the risk increases that our product candidates or other business activities may be subject to claims of\plain\cf1\f51\fs20\qj infringement of the patent and other proprietary rights of third parties. Third parties may assert that we are employing their\plain\cf1\f51\fs20\qj proprietary technology without authorization. There may be third-party patents or patent applications with claims to materials,\plain\cf1\f51\fs20\qj formulations, methods of manufacture or methods for treatment related to the use or manufacture of brincidofovir and/or our\plain\cf1\f51\fs20\qj other product candidates. Because patent applications can take many years to issue, there may be currently pending patent\plain\cf1\f51\fs20\qj applications which may later result in issued patents that our product candidates may infringe. In addition, third parties may\plain\cf1\f51\fs20\qj obtain patents in the future and claim that use of our technologies infringes upon these patents. If any third-party patents were\plain\cf1\f51\fs20\qj held by a court of competent jurisdiction to cover the manufacturing process of any of our product candidates, any molecules\plain\cf1\f51\fs20\qj formed during the manufacturing process or any final product itself, the holders of any such patents may be able to block our\plain\cf1\f51\fs20\qj ability to commercialize such product candidate unless we obtained a license under the applicable patents, or until such patents\plain\cf1\f51\fs20\qj expire.
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj Similarly, if any third-party patent were held by a court of competent jurisdiction to cover aspects of our formulations, processes\plain\cf1\f51\fs20\qj for manufacture or methods of use, including combination therapy, the holders of any such patent may be able to block our\plain\cf1\f51\fs20\qj ability to develop and commercialize the applicable product candidate unless we obtained a license or until such patent expires.\plain\cf1\f51\fs20\qj In either case, such a license may not be available on commercially reasonable terms or at all. In addition, we may be subject to\plain\cf1\f51\fs20\qj claims that we are infringing other intellectual property rights, such as trademarks or copyrights, or misappropriating the trade\plain\cf1\f51\fs20\qj secrets of others, and to the extent that our employees, consultants or contractors use intellectual property or proprietary\plain\cf1\f51\fs20\qj information owned by others in their work for us, disputes may arise as to the rights in related or resulting know-how and\plain\cf1\f51\fs20\qj inventions.
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\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj Parties making claims against us may obtain injunctive or other equitable relief, which could effectively block our ability to\plain\cf1\f51\fs20\qj further develop and commercialize one or more of our product candidates. Defense of these claims, regardless of their merit,\plain\cf1\f51\fs20\qj would involve substantial litigation expense and would be a substantial diversion of employee resources from our business. In the\plain\cf1\f51\fs20\qj event of a successful infringement or other intellectual property claim against us, we may have to pay substantial damages,\plain\cf1\f51\fs20\qj including treble damages and attorneys\u8217? fees for willful infringement, obtain one or more licenses from third parties, pay\plain\cf1\f51\fs20\qj royalties or redesign our affected products, which may be impossible or require substantial time and monetary expenditure. We\plain\cf1\f51\fs20\qj cannot predict whether any such license would be available at all or whether it would be available on commercially reasonable\plain\cf1\f51\fs20\qj terms. Furthermore, even in the absence of litigation, we may need to obtain licenses from third parties to advance our research\plain\cf1\f51\fs20\qj or allow commercialization of our product candidates, and we have done so from time to time. We may fail to obtain any of\plain\cf1\f51\fs20\qj these licenses at a reasonable cost or on reasonable terms, if at all. In that event, we would be unable to further develop and\plain\cf1\f51\fs20\qj commercialize one or more of our product candidates, which could harm our business significantly. We cannot provide any\plain\cf1\f51\fs20\qj assurances that third-party patents do not exist which might be enforced against our products or product candidates, resulting in\plain\cf1\f51\fs20\qj either an injunction prohibiting our sales, or, with respect to our sales, an obligation on our part to pay royalties and/or other\plain\cf1\f51\fs20\qj forms of compensation to third parties.\par\pard\plain\cf1\f51\fs20\qj \~\par\pard\plain\cf1\f51\fs20\b\i\qj We license certain key intellectual property from third parties, and the loss of our license rights could have a materially\plain\cf1\f51\fs20\b\i\qj adverse effect on our business.\par\pard\plain\fi792\cf1\f51\fs20\qj \~\par\pard\plain\cf1\f51\fs20\qj We are a party to a number of technology licenses that are important to our business and expect to enter into additional licenses\plain\cf1\f51\fs20\qj in the future. For example, we rely on an exclusive license to certain patents, proprietary technology and know-how from The\plain\cf1\f51\fs20\qj Regents of the University of California (UC), which we believe cover brincidofovir. If we fail to comply with our obligations\plain\cf1\f51\fs20\qj under our agreement with UC or our other license agreements, or we are subject to a bankruptcy, the licensor may have the right\plain\cf1\f51\fs20\qj to terminate the license, in which event we would not be able to develop or market products covered by the license, including in\plain\cf1\f51\fs20\qj the case of the UC license, brincidofovir, which would have a materially adverse effect on our business.\par\pard\plain\fi792\cf1\f51\fs20\qj \~\par\pard\plain\cf1\f51\fs20\b\i\qj We may be involved in lawsuits to protect or enforce our patents, the patents of our licensors or our other intellectual\plain\cf1\f51\fs20\b\i\qj property rights, which could be expensive, time consuming and unsuccessful.\par\pard\plain\fi792\cf1\f51\fs20\qj \~\par\pard\plain\cf1\f51\fs20\qj Competitors may infringe or otherwise violate our patents, the patents of our licensors or our other intellectual property rights. To\plain\cf1\f51\fs20\qj counter infringement or unauthorized use, we may be required to file legal claims, which can be expensive and time-consuming.\plain\cf1\f51\fs20\qj In addition, in an infringement proceeding, a court may decide that a patent of ours or our licensors is not valid or is\plain\cf1\f51\fs20\qj unenforceable, or may refuse to stop the other party from using the technology at issue on the grounds that our patents do not\plain\cf1\f51\fs20\qj cover the technology in question. An adverse result in any litigation or defense proceedings could put one or more of our patents\plain\cf1\f51\fs20\qj at risk of being invalidated or interpreted narrowly and could put our patent applications at risk of not issuing. The initiation of a\plain\cf1\f51\fs20\qj claim against a third party may also cause the third party to bring counter-claims against us.
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj We may not be able to prevent, alone or with our licensors, misappropriation of our intellectual property rights, particularly in\plain\cf1\f51\fs20\qj countries where the laws may not protect those rights as fully as in the United States. Our business could be harmed if in a\plain\cf1\f51\fs20\qj litigation the prevailing party does not offer us a license on commercially reasonable terms. Any litigation or other proceedings to\plain\cf1\f51\fs20\qj enforce our intellectual property rights may fail, and even if successful, may result in substantial costs and distract our\plain\cf1\f51\fs20\qj management and other employees.
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj Furthermore, because of the substantial amount of discovery required in connection with intellectual property litigation, there is a\plain\cf1\f51\fs20\qj risk that some of our confidential information could be compromised by disclosure during this type of litigation. There could also\plain\cf1\f51\fs20\qj be public announcements of the results of hearings, motions or other interim proceedings or developments. If securities analysts\plain\cf1\f51\fs20\qj or investors perceive these results to be negative, it could have a material adverse effect on the price of our common stock.\par\pard\plain\cf1\f51\fs20\qj \~\par\pard\plain\cf1\f51\fs20\b\i\qj Obtaining and maintaining our patent protection depends on compliance with various procedural, document submission, fee\plain\cf1\f51\fs20\b\i\qj payment and other requirements imposed by governmental patent agencies, and our patent protection could be reduced or\plain\cf1\f51\fs20\b\i\qj eliminated for non-compliance with these requirements.\par\pard\plain\fi792\cf1\f51\fs20\qj \~\par\pard\plain\cf1\f51\fs20\qj Periodic maintenance fees on any issued patent are due to be paid to the U.S. PTO and foreign patent agencies in several stages\plain\cf1\f51\fs20\qj over the lifetime of the patent. The U.S. PTO and various foreign governmental patent agencies require compliance with a\plain\cf1\f51\fs20\qj number of procedural, documentary, fee payment and other similar provisions during the patent application process.
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj While an inadvertent lapse can in many cases be cured by payment of a late fee or by other means in accordance with the\plain\cf1\f51\fs20\qj applicable rules, there are situations in which noncompliance can result in abandonment or lapse of the patent or patent\plain\cf1\f51\fs20\qj application, resulting in partial or complete loss of patent rights in the relevant jurisdiction. Non-compliance events that could\plain\cf1\f51\fs20\qj result in abandonment or lapse of a patent or patent application include, but are not limited to, failure to respond to official\plain\cf1\f51\fs20\qj actions within prescribed time
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\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj limits, non-payment of fees and failure to properly legalize and submit formal documents. If we or our licensors that control the\plain\cf1\f51\fs20\qj prosecution and maintenance of our licensed patents fail to maintain the patents and patent applications covering our product\plain\cf1\f51\fs20\qj candidates, we may lose our rights and our competitors might be able to enter the market, which would have a material adverse\plain\cf1\f51\fs20\qj effect on our business.\par\pard\plain\fi792\cf1\f51\fs20\qj \~\par\pard\plain\cf1\f51\fs20\b\qc Risks Related to Our United States Government Contracts and Grants\par\pard\plain\fi792\cf1\f51\fs20\b\i\qj \~\par\pard\plain\cf1\f51\fs20\b\i\qj All of our immediately foreseeable future revenues to support the development of brincidofovir for the treatment of smallpox\plain\cf1\f51\fs20\b\i\qj are dependent upon our contract with the Biomedical Advanced Research and Development Authority (BARDA), and if we do\plain\cf1\f51\fs20\b\i\qj not receive all of the funds under the BARDA contract we anticipate that we will suspend or terminate our smallpox\plain\cf1\f51\fs20\b\i\qj program.*\par\pard\plain\fi792\cf1\f51\fs20\qj \~\par\pard\plain\cf1\f51\fs20\qj Substantially all of our revenues that support the development of brincidofovir for the treatment of smallpox have been derived\plain\cf1\f51\fs20\qj from prior government grants and our current contract with BARDA. Our contract with BARDA is for the development of\plain\cf1\f51\fs20\qj brincidofovir for the treatment of smallpox. It is divided into a base segment and four option segments. We substantially\plain\cf1\f51\fs20\qj completed performance under the first option segment of the contract in August 2014 and are currently performing under the\plain\cf1\f51\fs20\qj second and third option segments of the contract which are scheduled to end in June 2016 and October 2016, respectively.\plain\cf1\f51\fs20\qj Subsequent option segments are not subject to automatic renewal and are not exercisable at our discretion. There can be no\plain\cf1\f51\fs20\qj assurance that we will reach agreement with BARDA on the most appropriate development pathway or that the FDA will\plain\cf1\f51\fs20\qj ultimately agree with the experiments which we perform or the appropriateness of the results of these experiments for approval of\plain\cf1\f51\fs20\qj brincidofovir for smallpox. In addition, there can be no assurance that any of the subsequent option segments will be exercised or\plain\cf1\f51\fs20\qj that we will continue to receive revenues under this contract once the current option segment is completed. We do not anticipate\plain\cf1\f51\fs20\qj continuing this program without ongoing support from BARDA.
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj Additionally, the contract provides for reimbursement of the costs of the development of brincidofovir for the treatment of\plain\cf1\f51\fs20\qj smallpox that are allowable under the Federal Acquisition Regulation (FAR), plus the payment of a fixed fee. It does not include\plain\cf1\f51\fs20\qj the manufacture of brincidofovir for the Strategic National Stockpile. There can be no assurances that this contract will continue,\plain\cf1\f51\fs20\qj that BARDA will extend the contract for additional option segments, that any such extension would be on favorable terms, or\plain\cf1\f51\fs20\qj that we will be able to enter into new contracts with the United States government to support our smallpox program. Changes in\plain\cf1\f51\fs20\qj government budgets and agendas may result in a decreased and de-prioritized emphasis on supporting the discovery and\plain\cf1\f51\fs20\qj development of brincidofovir for the treatment of smallpox. In such event, BARDA is not required to continue funding our\plain\cf1\f51\fs20\qj existing contract. Any such reduction in our revenues from BARDA or any other government contract could materially adversely\plain\cf1\f51\fs20\qj affect our financial condition and results of operations. In addition, if we do not receive all of the funds under the BARDA\plain\cf1\f51\fs20\qj contract, we anticipate that we will suspend or terminate our program for the development of brincidofovir for the treatment of\plain\cf1\f51\fs20\qj smallpox.
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\b\i\ql There can be no assurances that we will be able to enter into a contract with BARDA to act as the sole supplier for the\plain\cf1\f51\fs20\b\i\ql procurement of brincidofovir for the treatment of smallpox.*
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj In April 2015, BARDA posted a notice of intent to use other than full and open competition to award a sole source contract to\plain\cf1\f51\fs20\qj us for the procurement of brincidofovir for the treatment of smallpox.\~ In May 2015, BARDA posted an approved justification for\plain\cf1\f51\fs20\qj the use of other than full and open competition for the contract.\~ In July 2015, BARDA issued a related request for proposal\plain\cf1\f51\fs20\qj (RFP) to us entitled \u8220?2015 Procurement of a Second Smallpox Antiviral Drug for the Strategic National Stockpile."\~\plain\cf1\f51\fs20\qj Notwithstanding the issuance of the RFP, there can be no assurances that we will enter into a contract with BARDA to act as the\plain\cf1\f51\fs20\qj sole supplier for the procurement of brincidofovir for the treatment of smallpox.
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj Before we can enter into the contract we must negotiate its terms, including the price and delivery schedule.\~\~In addition, as a\plain\cf1\f51\fs20\qj governmental agency, BARDA\u8217?s ability to enter into a contract is subject to continued funding for this purpose, which can\plain\cf1\f51\fs20\qj change at any time. In August 2015, we submitted a response to the RFP and we subsequently engaged in discussions with\plain\cf1\f51\fs20\qj BARDA regarding our response.\~\~ We understand that BARDA had intended to make a contract award on or prior to September\plain\cf1\f51\fs20\qj 30, 2015, the end of the U.S. government's fiscal year, but the contract award was postponed due to a delay in Congressional\plain\cf1\f51\fs20\qj approval for the necessary appropriations.\~ We intend to have further discussions with BARDA and seek to promptly finalize the\plain\cf1\f51\fs20\qj contract award once the requisite budgetary funding has been approved. We are optimistic that we will be able to enter into a\plain\cf1\f51\fs20\qj contract with BARDA once BARDA is able to secure the requisite budgetary funding, but we cannot guarantee that the necessary\plain\cf1\f51\fs20\qj funding will be approved or made available, or if so, that we will be able to finalize a contract with BARDA on acceptable\plain\cf1\f51\fs20\qj terms.
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\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\b\i\qj Unfavorable provisions in government contracts, including our contract with BARDA, may harm our business, financial\plain\cf1\f51\fs20\b\i\qj condition and operating results.\par\pard\plain\fi792\cf1\f51\fs20\qj \~\par\pard\plain\cf1\f51\fs20\qj United States government contracts typically contain unfavorable provisions and are subject to audit and modification by the\plain\cf1\f51\fs20\qj government at its sole discretion, which will subject us to additional risks. For example, under our contract with BARDA, the\plain\cf1\f51\fs20\qj U.S. government has the power to unilaterally:
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj audit and object to any BARDA contract-related costs and fees on grounds that they are not allowable under the\plain\intbl\cf1\f51\fs20\qj FAR, and require us to reimburse all such costs and fees;\cell{
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj suspend or prevent us for a set period of time from receiving new contracts or extending our existing contract based\plain\intbl\cf1\f51\fs20\qj on violations or suspected violations of laws or regulations;\cell{
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj claim nonexclusive, nontransferable rights to product manufactured and intellectual property developed under the\plain\intbl\cf1\f51\fs20\qj BARDA contract and may, under certain circumstances, such as circumstances involving public health and safety,\plain\intbl\cf1\f51\fs20\qj license such inventions to third parties without our consent;\cell{
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj cancel, terminate or suspend our BARDA contract based on violations or suspected violations of laws or\plain\intbl\cf1\f51\fs20\qj regulations;\cell{
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj terminate our BARDA contract in whole or in part for the convenience of the government for any reason or no\plain\intbl\cf1\f51\fs20\qj reason, including if funds become unavailable to the applicable governmental agency;\cell{
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj reduce the scope and value of our\plain\intbl\cf1\f51\fs20\qj BARDA contract;\cell{
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj decline to exercise an option to continue the\plain\intbl\cf1\f51\fs20\qj BARDA contract;\cell{
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj direct the course of a development program in a manner not chosen by the government\plain\intbl\cf1\f51\fs20\qj contractor;\cell{
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj require us to perform the option segments even if doing so may cause us to forego or delay the pursuit of other\plain\intbl\cf1\f51\fs20\qj opportunities with greater commercial potential;\cell{
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj take actions that result in a longer development timeline than\plain\intbl\cf1\f51\fs20\qj expected; and\cell{
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj change certain terms and conditions in our\plain\intbl\cf1\f51\fs20\qj BARDA contract.\cell{
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\par\pard\plain\fs16\pard\plain\cf1\f51\fs20\qj The U.S. government also has the right to terminate the BARDA contract if termination is in the government\u8217?s interest, or\plain\cf1\f51\fs20\qj if we default by failing to perform in accordance with the milestones set forth in the contract. Termination-for-convenience\plain\cf1\f51\fs20\qj provisions generally enable us to recover only our costs incurred or committed (plus a portion of the agreed fee) and settlement\plain\cf1\f51\fs20\qj expenses on the work completed prior to termination. Except for the amount of services received by the government,\plain\cf1\f51\fs20\qj termination-for-default provisions do not permit recovery of fees.\par\pard\plain\fi792\cf1\f51\fs20\qj \~\par\pard\plain\cf1\f51\fs20\qj In addition, we must comply with numerous laws and regulations that affect how we conduct business with the United States\plain\cf1\f51\fs20\qj government. Among the most significant government contracting regulations that affect our business are:\par\pard\plain\fi792\cf1\f51\fs20\qj \~
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj FAR, and agency-specific regulations supplements to the FAR, which comprehensively regulate the procurement,\plain\intbl\cf1\f51\fs20\qj formation, administration and performance of government contracts and implement federal procurement policy in\plain\intbl\cf1\f51\fs20\qj numerous areas, such as employment practices, protection of the environment, accuracy and retention periods of\plain\intbl\cf1\f51\fs20\qj records, recording and charging of costs, treatment of laboratory animals and human subject research;\cell{
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj business ethics and public integrity obligations, which govern conflicts of interest and the hiring of former\plain\intbl\cf1\f51\fs20\qj government employees, restrict the granting of gratuities and funding of lobbying activities and incorporate other\plain\intbl\cf1\f51\fs20\qj requirements such as the Anti-Kickback Act and the Foreign Corrupt Practices Act;\cell{
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj export and import control laws and\plain\intbl\cf1\f51\fs20\qj regulations; and\cell{
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj laws, regulations and executive orders restricting the use and dissemination of information classified for national\plain\intbl\cf1\f51\fs20\qj security purposes and the exportation of certain products and technical data.\cell{
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\par\pard\plain\fs16\pard\plain\cf1\f51\fs20\qj Furthermore, we may be required to enter into agreements and subcontracts with third parties, including suppliers, consultants and\plain\cf1\f51\fs20\qj other third-party contractors, in order to satisfy our contractual obligations pursuant to our agreements with the U.S. government.\plain\cf1\f51\fs20\qj Negotiating and entering into such arrangements can be time-consuming and we may not be able to reach agreement with such\plain\cf1\f51\fs20\qj third parties. Any such agreement must also be compliant with the terms of our government contract. Any delay or inability to\plain\cf1\f51\fs20\qj enter into such arrangements or entering into such arrangements in a manner that is non-compliant with the terms of our\plain\cf1\f51\fs20\qj contract, may result in violations of our contract.
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj As a result of these unfavorable provisions, we must undertake significant compliance activities. The diversion of resources from\plain\cf1\f51\fs20\qj commercial programs to these compliance activities, as well as the exercise by the U.S. government of any rights under these\plain\cf1\f51\fs20\qj provisions, could materially harm our business.\par\pard\plain\fi792\cf1\f51\fs20\qj \~
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\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\b\i\qj Our business is subject to audit by the U.S. government, including under our contract with BARDA, and a negative audit\plain\cf1\f51\fs20\b\i\qj could adversely affect our business.\par\pard\plain\fi792\cf1\f51\fs20\qj \~\par\pard\plain\cf1\f51\fs20\qj United States government agencies, such as the Department of Health and Human Services (DHHS), routinely audit and\plain\cf1\f51\fs20\qj investigate government contractors and recipients of federal grants, including our contract with BARDA. These agencies review a\plain\cf1\f51\fs20\qj contractor\u8217?s performance under its contracts, cost structure and compliance with applicable laws, regulations and standards.\par\pard\plain\cf1\f51\fs20\qj \~\par\pard\plain\cf1\f51\fs20\qj The DHHS can also review the adequacy of, and a contractor\u8217?s compliance with, its internal control systems and policies,\plain\cf1\f51\fs20\qj including the contractor\u8217?s purchasing, property, estimating, compensation and management information systems. Any costs\plain\cf1\f51\fs20\qj found to be improperly allocated to a specific contract will not be reimbursed, while such costs already reimbursed must be\plain\cf1\f51\fs20\qj refunded. If an audit uncovers improper or illegal activities, we may be subject to civil and criminal penalties and administrative\plain\cf1\f51\fs20\qj sanctions, including:\par\pard\plain\fi792\cf1\f51\fs20\qj \~
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj termination of\plain\intbl\cf1\f51\fs20\qj contracts;\cell{
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj forfeiture of\plain\intbl\cf1\f51\fs20\qj profits;\cell{
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj suspension of\plain\intbl\cf1\f51\fs20\qj payments;\cell{
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj fines;\plain\intbl\cf1\f51\fs20\qj and\cell{
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj suspension or prohibition from conducting business with the U.S.\plain\intbl\cf1\f51\fs20\qj government.\cell{
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\par\pard\plain\fs16\pard\plain\cf1\f51\fs20\qj In addition, we could suffer serious reputational harm if allegations of impropriety were made against us by the U.S. government,\plain\cf1\f51\fs20\qj which could adversely affect our business.
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\b\i\qj Agreements with government agencies may lead to claims against us under the Federal False Claims Act, and these claims\plain\cf1\f51\fs20\b\i\qj could result in substantial fines and other penalties.\par\pard\plain\fi792\cf1\f51\fs20\qj \~\par\pard\plain\cf1\f51\fs20\qj The biopharmaceutical industry is, and in recent years has been, under heightened scrutiny as the subject of government\plain\cf1\f51\fs20\qj investigations and enforcement actions. Our BARDA contract is subject to substantial financial penalties under the Federal Civil\plain\cf1\f51\fs20\qj Monetary Penalties Act and the Federal Civil False Claims Act (False Claims Act). The False Claims Act imposes liability on\plain\cf1\f51\fs20\qj any person who, among other things, knowingly presents, or causes to be presented, a false record or statement material to a false\plain\cf1\f51\fs20\qj or fraudulent claim paid or approved by the government. Under the False Claims Act\u8217?s \u8220?whistleblower\u8221?\plain\cf1\f51\fs20\qj provisions, private enforcement of fraud claims against businesses on behalf of the U.S. government has increased due in part to\plain\cf1\f51\fs20\qj amendments to the False Claims Act that encourage private individuals to sue on behalf of the government. These whistleblower\plain\cf1\f51\fs20\qj suits, known as\plain\cf1\f51\fs20\i\qj qui\plain\cf1\f51\fs20\i\qj tam\plain\cf1\f51\fs20\qj actions, may be filed by private individuals, including present and former employees. The False Claims\plain\cf1\f51\fs20\qj Act provides for treble damages and up to $11,000 per false claim. If our operations are found to be in violation of any of these\plain\cf1\f51\fs20\qj laws, or any other governmental regulations that apply to us, we may be subject to penalties, including civil and criminal\plain\cf1\f51\fs20\qj penalties, damages, fines, exclusion from the Medicare and Medicaid programs, and the curtailment or restructuring of our\plain\cf1\f51\fs20\qj operations. Any penalties, damages, fines, exclusions, curtailment, or restructuring of our operations could adversely affect our\plain\cf1\f51\fs20\qj ability to operate our business and our financial results.
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\b\qc Risks Related to Our Business Operations and Industry\par\pard\plain\fi792\cf1\f51\fs20\qj \~\par\pard\plain\cf1\f51\fs20\b\i\qj Increasing demand for compassionate use of our unapproved therapies could result in losses.*
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj We are developing brincidofovir for life-threatening illness for which there are currently limited to no\~available\~therapeutic\plain\cf1\f51\fs20\qj options. During 2014, we were the target of an active and\~disruptive\~social media campaign\~related\~to a request for access to our\plain\cf1\f51\fs20\qj unapproved drug, brincidofovir. If we experience similar social media campaigns in the future, we may experience significant\plain\cf1\f51\fs20\qj disruption to our business which could result in losses.
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj Recent media attention to individual patients' expanded access requests has resulted in the introduction of legislation at the local\plain\cf1\f51\fs20\qj and national level referred to as "Right to Try" laws which are intended to give patients access to unapproved therapies. New and\plain\cf1\f51\fs20\qj emerging legislation regarding expanded access to unapproved drugs for life-threatening illnesses could negatively impact our\plain\cf1\f51\fs20\qj business in the future.
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj A possible consequence of both activism and legislation in this area is the need for us to initiate an unanticipated expanded\plain\cf1\f51\fs20\qj access program or to make brincidofovir more widely available sooner than anticipated. We are a small company with limited\plain\cf1\f51\fs20\qj resources and unanticipated trials or access programs could result in diversion of resources from our primary goals.
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj In addition, patients who receive access to unapproved drugs through compassionate use or expanded access programs have\plain\cf1\f51\fs20\qj life-threatening illnesses and have exhausted all other available therapies. The risk for serious adverse events in this patient\plain\cf1\f51\fs20\qj population
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\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj is high which could have a negative impact on the safety profile of brincidofovir, which could cause significant delays or an\plain\cf1\f51\fs20\qj inability to successfully commercialize brincidofovir, which would materially harm our business.
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\b\i\qj If we fail to comply with the extensive legal and regulatory requirements affecting the health care industry, we could face\plain\cf1\f51\fs20\b\i\qj increased costs, delays in the development of our product candidates, penalties and a loss of business.
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj Our activities, and the activities of our collaborators, partners and third-party providers, are subject to extensive government\plain\cf1\f51\fs20\qj regulation and oversight both in the United States and in foreign jurisdictions. The FDA and comparable agencies in other\plain\cf1\f51\fs20\qj jurisdictions directly regulate many of our most critical business activities, including the conduct of preclinical and clinical\plain\cf1\f51\fs20\qj studies, product manufacturing, advertising and promotion, product distribution, adverse event reporting and product risk\plain\cf1\f51\fs20\qj management. States increasingly have been placing greater restrictions on the marketing practices of healthcare companies. In\plain\cf1\f51\fs20\qj addition, pharmaceutical and biotechnology companies have been the target of lawsuits and investigations alleging violations of\plain\cf1\f51\fs20\qj government regulations, including claims asserting submission of incorrect pricing information, impermissible off-label promotion\plain\cf1\f51\fs20\qj of pharmaceutical products, payments intended to influence the referral of federal or state healthcare business, submission of false\plain\cf1\f51\fs20\qj claims for government reimbursement, antitrust violations, violations of the Foreign Corrupt Practices Act, or violations related to\plain\cf1\f51\fs20\qj environmental matters. Violations of governmental regulation may be punishable by criminal and civil sanctions, including fines\plain\cf1\f51\fs20\qj and civil monetary penalties and exclusion from participation in government programs, including Medicare and Medicaid. In\plain\cf1\f51\fs20\qj addition to penalties for violation of laws and regulations, we could be required to delay or terminate the development of our\plain\cf1\f51\fs20\qj product candidates, or we could be required to repay amounts we received from government payers, or pay additional rebates and\plain\cf1\f51\fs20\qj interest if we are found to have miscalculated the pricing information we have submitted to the government. Whether or not we\plain\cf1\f51\fs20\qj have complied with the law, an investigation into alleged unlawful conduct could increase our expenses, damage our reputation,\plain\cf1\f51\fs20\qj divert management time and attention and adversely affect our business.
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\b\i\qj Our future success depends on our ability to retain key executives and to attract, retain and motivate qualified personnel.*\par\pard\plain\fi792\cf1\f51\fs20\qj \~\par\pard\plain\cf1\f51\fs20\qj We are highly dependent on the principal members of our executive team. While we have entered into employment agreements\plain\cf1\f51\fs20\qj or offer letters with each of our executive officers, any of them could leave our employment at any time, as all of our employees\plain\cf1\f51\fs20\qj are \u8220?at will\u8221? employees. We do not maintain \u8220?key person\u8221? insurance for any of our executives or other\plain\cf1\f51\fs20\qj employees. Recruiting and retaining other qualified employees for our business, including scientific and technical personnel, will\plain\cf1\f51\fs20\qj also be critical to our success. There is currently a shortage of appropriately skilled executives in our industry, which is likely to\plain\cf1\f51\fs20\qj continue. We also experience competition for the hiring of scientific and clinical personnel from universities and research\plain\cf1\f51\fs20\qj institutions. As a result, competition for skilled personnel is intense and the turnover rate can be high. We may not be able to\plain\cf1\f51\fs20\qj attract and retain personnel on acceptable terms given the competition among numerous pharmaceutical and biotechnology\plain\cf1\f51\fs20\qj companies for similar personnel. In addition, failure of any of our clinical studies may make it more challenging to recruit and\plain\cf1\f51\fs20\qj retain qualified personnel. The inability to recruit or loss of the services of any executive or key employee may adversely affect\plain\cf1\f51\fs20\qj the progress of our research, development and commercialization objectives.
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj In addition, we rely on consultants and advisors, including scientific and clinical advisors, to assist us in formulating our research\plain\cf1\f51\fs20\qj and development and commercialization strategy. Our consultants and advisors may be employed by employers other than us and\plain\cf1\f51\fs20\qj may have commitments under consulting or advisory contracts with other entities that may limit their availability to us, which\plain\cf1\f51\fs20\qj could also adversely affect the progress of our research, development and commercialization objectives.\par\pard\plain\fi792\cf1\f51\fs20\b\i\qj \~\par\pard\plain\cf1\f51\fs20\b\i\qj We will need to expand our organization, and we may experience difficulties in managing this growth, which could disrupt\plain\cf1\f51\fs20\b\i\qj our operations.*\par\pard\plain\fi792\cf1\f51\fs20\qj \~\par\pard\plain\cf1\f51\fs20\qj As of September\~30, 2015, we had 123 full-time employees. As our company matures, we expect to expand our employee base\plain\cf1\f51\fs20\qj to increase our managerial, clinical, scientific and engineering, operational, sales, and commercial teams. Future growth would\plain\cf1\f51\fs20\qj impose significant additional responsibilities on our management, including the need to identify, recruit, maintain, motivate and\plain\cf1\f51\fs20\qj integrate additional employees, consultants and contractors. Also, our management may need to divert a disproportionate amount\plain\cf1\f51\fs20\qj of its attention away from our day-to-day activities and devote a substantial amount of time to managing these growth activities.\plain\cf1\f51\fs20\qj We may not be able to effectively manage the expansion of our operations, which may result in weaknesses in our infrastructure,\plain\cf1\f51\fs20\qj give rise to operational mistakes, loss of business opportunities, loss of employees and reduced productivity among remaining\plain\cf1\f51\fs20\qj employees. Our expected growth could require significant capital expenditures and may divert financial resources from other\plain\cf1\f51\fs20\qj projects, such as the development of product candidates. If our management is unable to effectively manage our growth, our\plain\cf1\f51\fs20\qj expenses may increase more than expected, our ability to generate and/or grow revenues could be reduced, and we may not be\plain\cf1\f51\fs20\qj able to implement our business strategy. Our future financial performance and our ability to commercialize brincidofovir and our\plain\cf1\f51\fs20\qj other product candidates and compete effectively will depend, in part, on our ability to effectively manage any future growth.\par\pard\plain\cf1\f51\fs20\qj \~
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\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\b\i\qj Potential product liability lawsuits against us could cause us to incur substantial liabilities and to limit commercialization of\plain\cf1\f51\fs20\b\i\qj any products that we may develop.*\par\pard\plain\fi792\cf1\f51\fs20\qj \~\par\pard\plain\cf1\f51\fs20\qj The use of our product candidates, including brincidofovir, in clinical studies and the sale of any products for which we obtain\plain\cf1\f51\fs20\qj marketing approval exposes us to the risk of product liability claims. Product liability claims might be brought against us by\plain\cf1\f51\fs20\qj consumers, health care providers, pharmaceutical companies or others selling or otherwise coming into contact with our products.\plain\cf1\f51\fs20\qj On occasion, large judgments have been awarded in class action lawsuits based on drugs that had unanticipated adverse effects. If\plain\cf1\f51\fs20\qj we cannot successfully defend against product liability claims, we could incur substantial liability and costs. In addition,\plain\cf1\f51\fs20\qj regardless of merit or eventual outcome, product liability claims may result in:
\par\pard\plain\fs16
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj impairment of our business reputation and significant negative media\plain\intbl\cf1\f51\fs20\qj attention;\cell{
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj withdrawal of participants from our\plain\intbl\cf1\f51\fs20\qj clinical studies;\cell{
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj significant costs to defend the related litigation and related\plain\intbl\cf1\f51\fs20\qj litigation;\cell{
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj distraction of management\u8217?s attention from our primary\plain\intbl\cf1\f51\fs20\qj business;\cell{
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj substantial monetary awards to patients or other\plain\intbl\cf1\f51\fs20\qj claimants;\cell{
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\pard\plain
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj inability to commercialize our product candidates, including\plain\intbl\cf1\f51\fs20\qj brincidofovir; and\cell{
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj decreased demand for our product candidates, if approved for\plain\intbl\cf1\f51\fs20\qj commercial sale.\cell{
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\par\pard\plain\fs16\pard\plain\cf1\f51\fs20\qj We currently carry $15 million in product liability insurance covering our clinical trials. Our current product liability insurance\plain\cf1\f51\fs20\qj coverage may not be sufficient to reimburse us for any expenses or losses we may suffer. Moreover, insurance coverage is\plain\cf1\f51\fs20\qj becoming increasingly expensive and in the future we may not be able to maintain insurance coverage at a reasonable cost or in\plain\cf1\f51\fs20\qj sufficient amounts to protect us against losses due to liability. If and when we obtain marketing approval for our product\plain\cf1\f51\fs20\qj candidates, we intend to expand our insurance coverage to include the sale of commercial products; however, we may be unable\plain\cf1\f51\fs20\qj to obtain product liability insurance on commercially reasonable terms or in adequate amounts. A successful product liability\plain\cf1\f51\fs20\qj claim or series of claims brought against us could cause our stock price to decline and, if judgments exceed our insurance\plain\cf1\f51\fs20\qj coverage, could adversely affect our results of operations and business.
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\b\i\qj Risks associated with expanding our operations to Europe could adversely affect our business.*
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj We plan to expand our operations and conduct certain development activities in Europe. We have limited experience with\plain\cf1\f51\fs20\qj conducting activities outside of the United States. International operations and business expansion plans are subject to numerous\plain\cf1\f51\fs20\qj additional risks, including:
\par\pard\plain\fs16
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj complexities associated with managing government payor systems, multiple payor-reimbursement regimes or patient\plain\intbl\cf1\f51\fs20\qj self-pay systems;\cell{
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj financial risks, such as longer payment cycles, difficulty enforcing contracts and collecting accounts receivable and\plain\intbl\cf1\f51\fs20\qj exposure to foreign currency exchange rate fluctuations;\cell{
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj general political and economic conditions in the countries in operate, including terrorism and political unrest,\plain\intbl\cf1\f51\fs20\qj curtailment of trade and other business restrictions;\cell{
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj regulatory and compliance risks that relate to maintaining accurate information and control over activities that may\plain\intbl\cf1\f51\fs20\qj fall within the purview of the U.S. Foreign Corrupt Practices Act, its books and records provisions or its\plain\intbl\cf1\f51\fs20\qj anti-bribery provisions, or similar anti-bribery or anti-corruption laws and regulations.\cell{
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\par\pard\plain\fs16\pard\plain\cf1\f51\fs20\qj Any of these risks, if encountered, could significantly increase our costs of operating internationally, prevent us from operating in\plain\cf1\f51\fs20\qj certain jurisdictions, or otherwise significantly harm our future international expansion and operations, which could have a\plain\cf1\f51\fs20\qj material adverse effect on our business, financial condition and results of operations.
\par\pard\plain\fs16
\par\pard\plain\fs16
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qc 49
\par\pard\plain\fs16\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par
\page
\par\pard\plain\fs16
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\b\qc Risk Related To Our Common Stock\par\pard\plain\fi792\cf1\f51\fs20\qj \~\par\pard\plain\cf1\f51\fs20\b\i\qj The market price of our common stock is likely to be volatile, and you may not be able to resell your shares at or above your\plain\cf1\f51\fs20\b\i\qj purchase price.\par\pard\plain\fi792\cf1\f51\fs20\qj \~\par\pard\plain\cf1\f51\fs20\qj Prior to our initial public offering (IPO) in 2013, there was no public market for our common stock. The trading price of our\plain\cf1\f51\fs20\qj common stock is likely to be volatile for the foreseeable future. Our stock price could be subject to wide fluctuations in response\plain\cf1\f51\fs20\qj to a variety of factors, including the following:
\par\pard\plain\fs16
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj results of clinical trials of our product candidates or those of our\plain\intbl\cf1\f51\fs20\qj competitors;\cell{
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj any delay in filing an application for any of our product candidates and any adverse development or perceived\plain\intbl\cf1\f51\fs20\qj adverse development with respect to regulatory review of that application;\cell{
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj failure to successfully develop and commercialize our product candidates, including\plain\intbl\cf1\f51\fs20\qj brincidofovir;\cell{
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj inability to obtain adequate product supply for our product candidates, or the inability to do so at acceptable\plain\intbl\cf1\f51\fs20\qj prices;\cell{
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj the other factors described in this \u8220?Risk Factors\u8221?\plain\intbl\cf1\f51\fs20\qj section.\cell{
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\par\pard\plain\fs16\pard\plain\cf1\f51\fs20\qj In addition, the stock market in general, and The Nasdaq Global Market in particular, have experienced extreme price and\plain\cf1\f51\fs20\qj volume fluctuations that have often been unrelated or disproportionate to the operating performance of these companies. Broad\plain\cf1\f51\fs20\qj market and industry factors may negatively affect the market price of our common stock, regardless of our actual operating\plain\cf1\f51\fs20\qj performance.\par\pard\plain\fi792\cf1\f51\fs20\b\i\qj \~\par\pard\plain\cf1\f51\fs20\b\i\qj Our principal stockholders and management own a significant percentage of our stock and will be able to exert significant\plain\cf1\f51\fs20\b\i\qj control over matters subject to stockholder approval.*\par\pard\plain\fi792\cf1\f51\fs20\qj \~\par\pard\plain\cf1\f51\fs20\qj Based upon shares of common stock outstanding as of September\~30, 2015, our executive officers, directors, 5% stockholders\plain\cf1\f51\fs20\qj (known to us through available information) and their affiliates beneficially owned approximately 45% of our voting stock.\plain\cf1\f51\fs20\qj Therefore, these stockholders have the ability to substantially influence us through this ownership position. For example, these\plain\cf1\f51\fs20\qj stockholders, if they choose to act together, may be able to influence the election of directors, amendments of our organizational\plain\cf1\f51\fs20\qj documents, or approval of any merger, sale of assets, or other major corporate transaction. This concentration of voting power\plain\cf1\f51\fs20\qj could delay or prevent an acquisition of our company on terms that other stockholders may desire.\par\pard\plain\fi792\cf1\f51\fs20\b\i\qj \~\par\pard\plain\cf1\f51\fs20\b\i\qj We are an \u8220?emerging growth company,\u8221? and we cannot be certain if the reduced reporting requirements\plain\cf1\f51\fs20\b\i\qj applicable to emerging growth companies will make our common stock less attractive to investors.*\par\pard\plain\fi792\cf1\f51\fs20\qj \~\par\pard\plain\cf1\f51\fs20\qj We are an \u8220?emerging growth company,\u8221? as defined in the JOBS Act. For as long as we continue to be an emerging\plain\cf1\f51\fs20\qj growth company, we may take advantage of exemptions from various reporting requirements that are applicable to other public\plain\cf1\f51\fs20\qj companies that are not \u8220?emerging growth companies,\u8221? including exemption from compliance with auditor attestation\plain\cf1\f51\fs20\qj requirements of Section 404 of the Sarbanes-Oxley Act of 2002 (Sarbanes-Oxley Act), reduced disclosure obligations regarding\plain\cf1\f51\fs20\qj executive compensation in the Company\u8217?s definitive proxy statement filed with the Securities and Exchange Commission\plain\cf1\f51\fs20\qj on April 29, 2015 and our periodic reports, and exemptions from the requirements of holding a nonbinding advisory vote on\plain\cf1\f51\fs20\qj executive compensation and stockholder
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\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj approval of any golden parachute payments not previously approved. We will remain an emerging growth company until\plain\cf1\f51\fs20\qj December 31, 2015.
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj Under the JOBS Act, emerging growth companies can also delay adopting new or revised accounting standards until such time as\plain\cf1\f51\fs20\qj those standards apply to private companies. We have irrevocably elected not to avail ourselves of this exemption from new or\plain\cf1\f51\fs20\qj revised accounting standards and, therefore, will be subject to the same new or revised accounting standards as other public\plain\cf1\f51\fs20\qj companies that are not emerging growth companies.
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\b\i\qj Failure to establish and maintain adequate finance infrastructure and accounting systems and controls could impair our\plain\cf1\f51\fs20\b\i\qj ability to comply with the financial reporting and internal controls requirements for publicly traded companies.*
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj As a public company, we operate in an increasingly demanding regulatory environment, which requires us to comply with the\plain\cf1\f51\fs20\qj Sarbanes-Oxley Act of 2002, and the related rules and regulations of the Securities and Exchange Commission, expanded\plain\cf1\f51\fs20\qj disclosure requirements, accelerated reporting requirements and more complex accounting rules. Company responsibilities\plain\cf1\f51\fs20\qj required by the Sarbanes-Oxley Act include establishing and maintaining corporate oversight and adequate internal control over\plain\cf1\f51\fs20\qj financial reporting and disclosure controls and procedures. Effective internal controls are necessary for us to produce reliable\plain\cf1\f51\fs20\qj financial reports and are important to help prevent financial fraud.
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj Our compliance with Section 404 of the Sarbanes-Oxley Act has required and will continue to require that we incur substantial\plain\cf1\f51\fs20\qj accounting expense and expend significant management efforts. In this or future years, our testing, or the subsequent testing by\plain\cf1\f51\fs20\qj our independent registered public accounting firm, may reveal deficiencies in our internal controls that we would be required to\plain\cf1\f51\fs20\qj remediate in a timely manner so as to be able to comply with the requirements of Section 404 of the Sarbanes-Oxley Act each\plain\cf1\f51\fs20\qj year. If we are not able to comply with the requirements of Section 404 of the Sarbanes-Oxley Act in a timely manner each\plain\cf1\f51\fs20\qj year, we could be subject to sanctions or investigations by the Securities and Exchange Commission, the NASDAQ Stock Market\plain\cf1\f51\fs20\qj or other regulatory authorities which would require additional financial and management resources and could adversely affect the\plain\cf1\f51\fs20\qj market price of our common stock. Furthermore, if we cannot provide reliable financial reports or prevent fraud, our business and\plain\cf1\f51\fs20\qj results of operations could be harmed and investors could lose confidence in our reported financial information.\par\pard\plain\cf1\f51\fs20\qj \~\plain\cf1\f51\fs20\b\i\qj \~\par\pard\plain\cf1\f51\fs20\b\i\qj Future sales and issuances of our common stock or rights to purchase common stock, including pursuant to our equity\plain\cf1\f51\fs20\b\i\qj incentive plans, could result in additional dilution of the percentage ownership of our stockholders and could cause our stock\plain\cf1\f51\fs20\b\i\qj price to fall.*\par\pard\plain\fi792\cf1\f51\fs20\qj \~\par\pard\plain\cf1\f51\fs20\qj We expect that significant additional capital will be needed in the future to continue our planned operations. To the extent we\plain\cf1\f51\fs20\qj raise additional capital by issuing equity securities, our stockholders may experience substantial dilution. We may sell common\plain\cf1\f51\fs20\qj stock, convertible securities or other equity securities in one or more transactions at prices and in a manner we determine from\plain\cf1\f51\fs20\qj time to time. For example, for so long as we continue to satisfy the requirements to be deemed a well-known seasoned filer, we\plain\cf1\f51\fs20\qj are permitted to file registration statements, which will be automatically effective, and allow us to sell an unlimited amount of\plain\cf1\f51\fs20\qj securities from time-to-time. If we sell common stock, convertible securities or other equity securities in more than one\plain\cf1\f51\fs20\qj transaction, investors may be materially diluted by subsequent sales. Such sales may also result in material dilution to our\plain\cf1\f51\fs20\qj existing stockholders, and new investors could gain rights superior to our existing stockholders.
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj Pursuant to our 2013 Equity Incentive Plan (the 2013 Plan), our management is authorized to grant stock options to our\plain\cf1\f51\fs20\qj employees, directors and consultants. The number of shares available for future grant under our 2013 Plan will automatically\plain\cf1\f51\fs20\qj increase on January 1st each year, through January 1, 2023, by an amount equal to 4.0% of all shares of our capital stock\plain\cf1\f51\fs20\qj outstanding as of December 31st of the preceding calendar year, subject to the ability of our board of directors to take action to\plain\cf1\f51\fs20\qj reduce the size of such increase in any given year. In addition, our board of directors may grant or provide for the grant of rights\plain\cf1\f51\fs20\qj to purchase shares of our common stock pursuant to the terms of our 2013 Employee Stock Purchase Plan (ESPP). The number\plain\cf1\f51\fs20\qj of shares of our common stock reserved for issuance under our ESPP will automatically increase on January 1st each year,\plain\cf1\f51\fs20\qj through January 1, 2023, by an amount equal to the lesser of 422,535 shares or one percent of all shares of our capital stock\plain\cf1\f51\fs20\qj outstanding as of December 31st of the preceding calendar year, subject to the ability of our board of directors to take action to\plain\cf1\f51\fs20\qj reduce the size of such increase in any given year. Unless our board of directors elects not to increase the number of shares\plain\cf1\f51\fs20\qj underlying our 2013 Plan and ESPP each year, our stockholders may experience additional dilution, which could cause our stock\plain\cf1\f51\fs20\qj price to fall.\par\pard\plain\cf1\f51\fs20\qj \~\par\pard\plain\cf1\f51\fs20\b\i\qj We have broad discretion in the use of the net proceeds from our financing transactions and may not use them effectively.\par\pard\plain\fi792\cf1\f51\fs20\qj \~\par\pard\plain\cf1\f51\fs20\qj Our management has broad discretion in the application of the net proceeds from our financing transactions. Because of the\plain\cf1\f51\fs20\qj number and variability of factors that will determine our use of the net proceeds from our financing transactions, their ultimate\plain\cf1\f51\fs20\qj use may vary substantially from their currently intended use. The failure by our management to apply these funds effectively\plain\cf1\f51\fs20\qj could result in financial losses that could have a material adverse effect on our business, cause the price of our common stock to\plain\cf1\f51\fs20\qj decline and
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\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj delay the development of our product candidates. Pending their use, we have invested the net proceeds from our financing\plain\cf1\f51\fs20\qj transactions in short-term, investment-grade, interest-bearing securities. These investments may not yield a favorable return to\plain\cf1\f51\fs20\qj our stockholders.\par\pard\plain\fi792\cf1\f51\fs20\b\i\qj \~\par\pard\plain\cf1\f51\fs20\b\i\qj Volatility in our stock price could subject us to securities class action litigation.\par\pard\plain\fi792\cf1\f51\fs20\qj \~\par\pard\plain\cf1\f51\fs20\qj In the past, securities class action litigation has often been brought against a company following a decline in the market price of\plain\cf1\f51\fs20\qj its securities. This risk is especially relevant for us because pharmaceutical companies have experienced significant stock price\plain\cf1\f51\fs20\qj volatility in recent years. If we face such litigation, it could result in substantial costs and a diversion of management\u8217?s\plain\cf1\f51\fs20\qj attention and resources, which could harm our business.\par\pard\plain\cf1\f51\fs20\qj \~\par\pard\plain\cf1\f51\fs20\b\i\qj Our ability to use our net operating loss carryforwards and certain other tax attributes may be limited.\par\pard\plain\fi792\cf1\f51\fs20\qj \~\par\pard\plain\cf1\f51\fs20\qj Under Section 382 of the Internal Revenue Code of 1986, as amended, if a corporation undergoes an \u8220?ownership\plain\cf1\f51\fs20\qj change,\u8221? generally defined as a greater than 50% change (by value) in its equity ownership over a three year period, the\plain\cf1\f51\fs20\qj corporation\u8217?s ability to use its pre-change net operating loss carryforwards and other pre-change tax attributes (such as\plain\cf1\f51\fs20\qj research tax credits) to offset its post-change income may be limited. We have determined that a Section 382 ownership change\plain\cf1\f51\fs20\qj occurred in 2002 and 2007 resulting in limitations of at least $64,000 and $762,000, respectively, of losses incurred prior to the\plain\cf1\f51\fs20\qj respective ownership change dates. In addition, we have determined that another Section 382 ownership change occurred in 2013\plain\cf1\f51\fs20\qj with our IPO, our most recent private placement and other transactions that have occurred since 2007, resulting in a limitation of\plain\cf1\f51\fs20\qj at least $6.7 million of losses incurred prior to the ownership change date. We may also experience ownership changes in the\plain\cf1\f51\fs20\qj future as a result of subsequent shifts in our stock ownership. As a result, if we earn net taxable income, our ability to use our\plain\cf1\f51\fs20\qj pre-change net operating loss carryforwards to offset United States federal taxable income may be subject to limitations, which\plain\cf1\f51\fs20\qj could potentially result in increased future tax liability.\par\pard\plain\cf1\f51\fs20\qj \~\par\pard\plain\cf1\f51\fs20\b\i\qj Because we do not anticipate paying any cash dividends on our common stock in the foreseeable future, capital appreciation,\plain\cf1\f51\fs20\b\i\qj if any, would be your sole source of gain.\par\pard\plain\fi792\cf1\f51\fs20\qj \~\par\pard\plain\cf1\f51\fs20\qj We have never declared or paid any cash dividends on our common stock. We currently anticipate that we will retain future\plain\cf1\f51\fs20\qj earnings for the development, operation and expansion of our business and do not anticipate declaring or paying any cash\plain\cf1\f51\fs20\qj dividends for the foreseeable future. As a result, capital appreciation, if any, of our common stock would be your sole source of\plain\cf1\f51\fs20\qj gain on an investment in our common stock for the foreseeable future.\par\pard\plain\cf1\f51\fs20\qj \~\par\pard\plain\cf1\f51\fs20\b\i\qj Provisions in our corporate charter documents and under Delaware law could make it more difficult for a third party to\plain\cf1\f51\fs20\b\i\qj acquire us or increase the cost of acquiring us, even if doing so would benefit our stockholders and may prevent attempts by\plain\cf1\f51\fs20\b\i\qj our stockholders to replace or remove our current management.\par\pard\plain\fi792\cf1\f51\fs20\qj \~\par\pard\plain\cf1\f51\fs20\qj Some provisions of our charter documents and Delaware law may have anti-takeover effects that could discourage an acquisition\plain\cf1\f51\fs20\qj of us by others, even if an acquisition would be beneficial to our stockholders and may prevent attempts by our stockholders to\plain\cf1\f51\fs20\qj replace or remove our current management. These provisions include:\par\pard\plain\fi792\cf1\f51\fs20\qj \~
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj authorizing the issuance of \u8220?blank check\u8221? preferred stock, the terms of which may be established and\plain\intbl\cf1\f51\fs20\qj shares of which may be issued without stockholder approval which could be used to institute a \u8220?poison\plain\intbl\cf1\f51\fs20\qj pill\u8221? that would work to dilute the stock ownership of a potential hostile acquirer, effectively preventing\plain\intbl\cf1\f51\fs20\qj acquisitions that have not been approved by our board of directors;\cell{
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj allowing the authorized number of our directors to be changed only by resolution of our board of directors;\cell{
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj limiting the removal of\plain\intbl\cf1\f51\fs20\qj directors;\cell{
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj creating a staggered board of\plain\intbl\cf1\f51\fs20\qj directors;\cell{
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj requiring that stockholder actions must be effected at a duly called stockholder meeting and prohibiting stockholder\plain\intbl\cf1\f51\fs20\qj actions by written consent;\cell{
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj eliminating the ability of stockholders to call a special meeting of\plain\intbl\cf1\f51\fs20\qj stockholders; and\cell{
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\pard\plain\intbl\li792\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\qj establishing advance notice requirements for nominations for election to the board of directors or for proposing\plain\intbl\cf1\f51\fs20\qj matters that can be acted upon at duly called stockholder meetings.\cell{
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\par\pard\plain\fs16\pard\plain\cf1\f51\fs20\qj The amendment of any of these provisions, with the exception of the ability of our board of directors to issue shares of preferred\plain\cf1\f51\fs20\qj stock and designate any rights, preferences and privileges thereto, would require the affirmative vote of the holders of at least\plain\cf1\f51\fs20\qj 66\~2/3% of the voting power of all of our then outstanding common stock.\par\pard\plain\fi792\cf1\f51\fs20\qj \~
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\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj These provisions may frustrate or prevent any attempts by our stockholders to replace or remove our current management by\plain\cf1\f51\fs20\qj making it more difficult for stockholders to replace members of our board of directors, which is responsible for appointing the\plain\cf1\f51\fs20\qj members of our management. In addition, we are subject to Section 203 of the Delaware General Corporation Law, which\plain\cf1\f51\fs20\qj generally prohibits a Delaware corporation from engaging in any of a broad range of business combinations with an interested\plain\cf1\f51\fs20\qj stockholder for a period of three years following the date on which the stockholder became an interested stockholder, unless such\plain\cf1\f51\fs20\qj transactions are approved by our board of directors. This provision could have the effect of delaying or preventing a change of\plain\cf1\f51\fs20\qj control, whether or not it is desired by or beneficial to our stockholders. Further, other provisions of Delaware law may also\plain\cf1\f51\fs20\qj discourage, delay or prevent someone from acquiring us or merging with us.
\par\pard\plain\fs16{\*\bkmkstart s180EDA1FD4A7CD7FAE1A6612A5DEF3B}{\*\bkmkend s180EDA1FD4A7CD7FAE1A6612A5DEF3B}{\*\bkmkstart item_1_3_7}{\*\bkmkend item_1_3_7}\par\pard\plain\cf1\f51\fs20\b\qj ITEM 2. \~\~\~\~\~\~\~\~UNREGISTERED SALES OF EQUITY SECURITIES AND USE OF PROCEEDS\par\pard\plain\fi792\cf1\f51\fs20\qj \~
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\b\i\qj Unregistered Sales of Equity Securities
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj On July 14, 2015, the Company issued an aggregate of 189,610 shares of its common stock in connection with the exercise of\plain\cf1\f51\fs20\qj warrants.\~ The aggregate exercise price for the shares of common stock issued was $1.6 million.
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj On August 5, 2015, the Company issued an aggregate of 150 shares of its common stock in connection with the exercise of a\plain\cf1\f51\fs20\qj warrant.\~ The aggregate exercise price for the shares of common stock issued was $1,200.
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj The issuances of the common stock described above were deemed to be exempt from registration under the Securities Act of\plain\cf1\f51\fs20\qj 1933, as amended (the Securities Act), in reliance on Section 4(2) of the Securities Act as transactions by an issuer not involving\plain\cf1\f51\fs20\qj a public offering. The recipients of common stock in the transactions acquired the securities for investment only and not with a\plain\cf1\f51\fs20\qj view to or for sale in connection with any distribution thereof. No underwriters were involved in these transactions.
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\b\i\qj Purchase of Equity Securities
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qj We did not purchase any of our registered securities during the period covered by this Quarterly Report on Form 10-Q.\par\pard\plain\fi792\cf1\f51\fs20\qj \~{\*\bkmkstart s86545F9E5936AE7DFE0D6612A60F15C}{\*\bkmkend s86545F9E5936AE7DFE0D6612A60F15C}{\*\bkmkstart item_1_3_8}{\*\bkmkend item_1_3_8}\par\pard\plain\cf1\f51\fs20\b\ql ITEM 3. \~\~\~\~DEFAULTS UPON SENIOR SECURITIES\par\pard\plain\fi792\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\ql None.\par\pard\plain\fi792\cf1\f51\fs20\ql \~{\*\bkmkstart sE53CD5C5FD0A16722AB86612A631F77}{\*\bkmkend sE53CD5C5FD0A16722AB86612A631F77}{\*\bkmkstart item_1_3_9}{\*\bkmkend item_1_3_9}\par\pard\plain\cf1\f51\fs20\b\ql ITEM 4. \~\~\~\~MINE SAFETY DISCLOSURES\par\pard\plain\fi792\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\ql Not applicable.\par\pard\plain\fi792\cf1\f51\fs20\ql \~{\*\bkmkstart s7A0528C382D09BA338D86612A662C06}{\*\bkmkend s7A0528C382D09BA338D86612A662C06}{\*\bkmkstart item_1_3_10}{\*\bkmkend item_1_3_10}\par\pard\plain\cf1\f51\fs20\b\ql ITEM 5. \~\~\~\~OTHER INFORMATION\par\pard\plain\fi792\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\ql Not applicable.\par\pard\plain\cf1\f51\fs20\qj \~
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\par\pard\plain\fs16{\*\bkmkstart item_1_3_11}{\*\bkmkend item_1_3_11}\par\pard\plain\cf1\f51\fs20\b\ql ITEM 6. \~\~\~\~EXHIBITS\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\ql The following exhibits are filed as part of this report:\~
\par\pard\plain
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\pard\plain\intbl\f0\fs16\ql \~\cell{
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\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\b\ql Number\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\qc \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\b\qc Description\cell{
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\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql 3.1(1)\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\qj \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\qj Amended and Restated Certificate of Incorporation of the Registrant.\cell{
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\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\qj \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\qj \~\cell{
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\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql 3.2(1)\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\qj \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\qj Amended and Restated Bylaws of the Registrant.\cell{
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\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\qj \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\qj \~\cell{
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\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql 4.1(2)\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\qj \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\qj Form of Common Stock Certificate of the Registrant.\cell{
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\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\qj \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\qj \~\cell{
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\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql 4.2(2)\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\qj \~\cell\pard\plain\intbl\li22\ri22\sb22\cf1\f51\fs20\qj Form of Warrant to Purchase Stock issued to participants in the Registrant's Series F Preferred Stock financing\plain\intbl\li22\ri22\sa22\cf1\f51\fs20\qj dated February 7, 2011.\cell{
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\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell{
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\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql 4.3(2)\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\qj \~\cell\pard\plain\intbl\li22\ri22\sb22\cf1\f51\fs20\qj Amended and Restated Investor Rights Agreement dated February 7, 2011 by and among the Registrant and\plain\intbl\li22\ri22\sa22\cf1\f51\fs20\qj certain of its stockholders.\cell{
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\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell{
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\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql 4.4(3)\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\qj \~\cell\pard\plain\intbl\li22\ri22\sb22\cf1\f51\fs20\qj Amendment to Amended and Restated Investor Rights Agreement dated October 29, 2014 by and among the\plain\intbl\li22\ri22\sa22\cf1\f51\fs20\qj Registrant and certain of its stockholders.\cell{
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\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql 10.1(4)\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\cf1\f51\fs20\qj Contract modification No. 27, dated July 14, 2015, to the contract by and between the Registrant and the\plain\intbl\li22\ri22\cf1\f51\fs20\qj Biomedical Advanced Research and Development Authority of the United States Department of Health and\plain\intbl\li22\ri22\sa22\cf1\f51\fs20\qj Human Services dated February 16, 2011, as amended.\cell{
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\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell{
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\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql 10.2*\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\cf1\f51\fs20\qj Contract modification No. 28, dated September 1, 2015, to the contract by and between the Registrant and the\plain\intbl\li22\ri22\cf1\f51\fs20\qj Biomedical Advanced Research and Development Authority of the United States Department of Health and\plain\intbl\li22\ri22\sa22\cf1\f51\fs20\qj Human Services dated February 16, 2011, as amended.\cell{
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\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell{
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\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql 10.3*\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\cf1\f51\fs20\qj Contract modification No. 29, dated September 11, 2015, to the contract by and between the Registrant and the\plain\intbl\li22\ri22\cf1\f51\fs20\qj Biomedical Advanced Research and Development Authority of the United States Department of Health and\plain\intbl\li22\ri22\sa22\cf1\f51\fs20\qj Human Services dated February 16, 2011, as amended.\cell{
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\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell{
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\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql 31.1\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\qj \~\cell\pard\plain\intbl\li22\ri22\sb22\cf1\f51\fs20\qj Certification of Principal Executive Officer pursuant to Rule\~13a-14(a)\~or Rule\~15d-14(a)\~of the Securities\plain\intbl\li22\ri22\sa22\cf1\f51\fs20\qj Exchange Act of 1934, as amended.\cell{
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\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\qj \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\qj \~\cell{
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\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql 31.2\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\qj \~\cell\pard\plain\intbl\li22\ri22\sb22\cf1\f51\fs20\qj Certification of Principal Financial Officer pursuant to Rule\~13a-14(a)\~or Rule\~15d-14(a)\~of the Securities\plain\intbl\li22\ri22\sa22\cf1\f51\fs20\qj Exchange Act of 1934, as amended.\cell{
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\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\qj \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\qj \~\cell{
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\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql 32.1\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\qj \~\cell\pard\plain\intbl\li22\ri22\sb22\cf1\f51\fs20\qj Certification of Principal Executive Officer pursuant to Rule\~13a-14(b)\~of the Securities Exchange Act of 1934,\plain\intbl\li22\ri22\cf1\f51\fs20\qj as amended, and 18 U.S.C. Section\~1350, as adopted pursuant to Section\~906 of the Sarbanes-Oxley Act of\plain\intbl\li22\ri22\sa22\cf1\f51\fs20\qj 2002.\cell{
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\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\qj \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\qj \~\cell{
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\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql 32.2\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\qj \~\cell\pard\plain\intbl\li22\ri22\sb22\cf1\f51\fs20\qj Certification of Principal Financial Officer pursuant to Rule\~13a-14(b)\~of the Securities Exchange Act of 1934,\plain\intbl\li22\ri22\sa22\cf1\f51\fs20\qj as amended, and 18 U.S.C. Section\~1350, as adopted pursuant Section\~906 of the Sarbanes-Oxley Act of 2002.\cell{
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\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell{
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\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql 101.INS\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\qj XBRL Instance Document.\cell{
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\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell{
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\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql 101.SCH\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\qj XBRL Taxonomy Extension Schema Document.\cell{
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\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell{
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\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql 101.CAL\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\qj XBRL Taxonomy Extension Calculation Linkbase Document.\cell{
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{\trowd\clvertalb\cellx1080\clvertalb\cellx1403\clvertalb\cellx10799\trrh281
\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell{
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\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql 101.DEF\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\qj XBRL Taxonomy Extension Definition Linkbase Document.\cell{
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\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell{
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\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql 101.LAB\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\qj XBRL Taxonomy Extension Label Linkbase Document.\cell{
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\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell{
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\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql 101.PRE\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\qj XBRL Taxonomy Extension Presentation Linkbase Document.\cell{
{\trowd\clvertalb\cellx1080\clvertalb\cellx1403\clvertalb\cellx10799\trrh281\row}}}\plain\sb154\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\ql *Confidential treatment has been requested with respect to certain portions of this exhibit. Omitted portions have been filed\plain\cf1\f51\fs20\ql separately with the SEC.
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\pard\plain\intbl\cf1\f51\fs20\ql (1)\cell\pard\plain\intbl\cf1\f51\fs20\qj Incorporated by reference to Chimerix, Inc.\u8217?s Current Report on Form 8-K (No. 001-35867), filed with the SEC on\plain\intbl\cf1\f51\fs20\qj April 16, 2013.\cell{
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\pard\plain\intbl\cf1\f51\fs20\ql (2)\cell\pard\plain\intbl\cf1\f51\fs20\qj Incorporated by reference to Chimerix, Inc.\u8217?s Registration Statement on Form S-1 (No. 333-187145), as amended.\cell{
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\pard\plain\intbl\cf1\f51\fs20\ql (3)\cell\pard\plain\intbl\cf1\f51\fs20\qj Incorporated by reference to Chimerix, Inc.'s Current Report on Form 8-K (No. 001-35867) filed with the SEC on October\plain\intbl\cf1\f51\fs20\qj 29, 2014.\cell{
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\pard\plain\intbl\cf1\f51\fs20\ql (4)\cell\pard\plain\intbl\cf1\f51\fs20\qj Incorporated by reference to Chimerix, Inc.'s Quarterly Report on Form 10-Q (No. 001-35867) filed with the SEC on August\plain\intbl\cf1\f51\fs20\qj 6, 2015.\cell{
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\par\pard\plain\fs16\pard\plain\cf1\f51\fs20\qc 54
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\par\pard\plain\fs16{\*\bkmkstart part_1_2_3}{\*\bkmkend part_1_2_3}\par\pard\plain\fi792\cf1\f51\fs20\b\qc SIGNATURES\par\pard\plain\fi792\cf1\f51\fs20\qc \~\par\pard\plain\cf1\f51\fs20\ql Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its\plain\cf1\f51\fs20\ql behalf by the undersigned thereunto duly authorized.\par\pard\plain\fi792\cf1\f51\fs20\qc \~
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\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\qj \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\qj CHIMERIX,\~INC.\cell{
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\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\qj \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\qj \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\qj \~\cell{
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\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\qj November\~5, 2015\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\qj By:\~\~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\qj /s/ M. Michelle Berrey\cell{
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\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\qj \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\qj \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\qj M. Michelle Berrey, MD, MPH\cell{
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{\trowd\clvertalb\cellx5451\clvertalb\cellx6202\clvertalb\cellx10798\trrh281
\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\qj \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\qj \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\qj President and Chief Executive Officer\cell{
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{\trowd\clvertalb\cellx5451\clvertalb\cellx6202\clvertalb\cellx10798\trrh281
\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\qj \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\qj \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\qj \~\cell{
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{\trowd\clvertalb\cellx5451\clvertalb\cellx6202\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10798\trrh281
\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\qj November\~5, 2015\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\qj By:\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\qj /s/ Timothy W. Trost\cell{
{\trowd\clvertalb\cellx5451\clvertalb\cellx6202\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10798\trrh281\row}}}
{\trowd\clvertalb\cellx5451\clvertalb\cellx6202\clvertalb\cellx10798\trrh281
\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\qj \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\qj \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\qj Timothy W. Trost\cell{
{\trowd\clvertalb\cellx5451\clvertalb\cellx6202\clvertalb\cellx10798\trrh281\row}}}
{\trowd\clvertalb\cellx5451\clvertalb\cellx6202\clvertalb\cellx10798\trrh529
\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\qj \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\qj \~\cell\pard\plain\intbl\li22\ri22\sb22\cf1\f51\fs20\qj Senior Vice President, Chief Financial Officer and\plain\intbl\li22\ri22\sa22\cf1\f51\fs20\qj Corporate Secretary\cell{
{\trowd\clvertalb\cellx5451\clvertalb\cellx6202\clvertalb\cellx10798\trrh529\row}}}\pard\plain\fi792\cf1\f51\fs20\ql \~
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\qc 55
\par\pard\plain\fs16
\page{\*\bkmkstart doc_1_2}{\*\bkmkend doc_1_2}{\*\bkmkstart s889BD60A1BAA10CCF130B43B979210F}{\*\bkmkend s889BD60A1BAA10CCF130B43B979210F}\par\pard\plain\cf1\f51\fs16\b\qr ***Text Omitted and Filed Separately\par\pard\plain\cf1\f51\fs16\b\qr With Securities and Exchange Commission\par\pard\plain\cf1\f51\fs16\b\qr Confidential Treatment Requested\par\pard\plain\cf1\f51\fs16\b\qr Under 17 C.F.R. Section 200.80(b)(4)\par\pard\plain\cf1\f51\fs16\b\qr and 240.24b-2
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\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
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\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs16\b\ql AMENDMENT OF SOLICITATION/MODIFICATION OF CONTRACT\cell\pard\plain\intbl\li132\ri22\sb22\sa22\fi-154\cf1\f52\fs12\ql 1. CONTRACT ID CODE\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs12\ql \~PAGE OF PAGES\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
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\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sa22\cf1\f51\fs18\qc 1\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs20\qr 23\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
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{\trowd\clbrdrt\brdrs\brdrcf1\clbrdrr\brdrs\brdrcf1\cellx2952\clbrdrt\brdrs\brdrcf1\cellx4679\clbrdrt\brdrs\brdrcf1\clbrdrl\brdrs\brdrcf1\cellx8028\clbrdrt\brdrs\brdrcf1\clbrdrl\brdrs\brdrcf1\cellx10616\clvertalc\cellx10617\clvertalc\cellx10618\clvertalc\cellx10619\clvertalc\cellx10620\clvertalc\cellx10621\cellx10672\trrh216
\pard\plain\intbl\li22\ri22\sa22\cf1\f52\fs12\ql 2. AMENDMENT/MODIFICATION NO.\cell\pard\plain\intbl\li22\ri22\sa22\cf1\f52\fs12\ql 3. EFFECTIVE DATE\cell\pard\plain\intbl\li22\ri22\sa22\cf1\f52\fs12\ql 4. REQUISITION/PURCHASE REQ. NO.\cell\pard\plain\intbl\li22\ri22\sb22\cf1\f52\fs12\ql \~5. PROJECT NO.\plain\intbl\li22\ri22\sa22\cf1\f52\fs12\i\ql (if applicable)\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
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{\trowd\clbrdrr\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\cellx2952\clbrdrb\brdrs\brdrcf1\cellx4679\clbrdrl\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\cellx8028\clbrdrl\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10616\clvertalc\cellx10617\clvertalc\cellx10618\clvertalc\cellx10619\clvertalc\cellx10620\clvertalc\cellx10621\cellx10672\trrh281
\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs18\ql 28\cell\pard\plain\intbl\li132\ri22\sb22\sa22\cf1\f51\fs18\ql See Block 16C\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs18\ql N/A.\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clbrdrr\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\cellx2952\clbrdrb\brdrs\brdrcf1\cellx4679\clbrdrl\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\cellx8028\clbrdrl\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10616\clvertalc\cellx10617\clvertalc\cellx10618\clvertalc\cellx10619\clvertalc\cellx10620\clvertalc\cellx10621\cellx10672\trrh281\row}}}
{\trowd\cellx1749\cellx2952\clbrdrl\brdrs\brdrcf1\clbrdrr\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\cellx4679\cellx7690\cellx8543\clbrdrl\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\cellx10615\clvertalc\cellx10616\clvertalc\cellx10617\clvertalc\cellx10618\clvertalc\cellx10619\clvertalc\cellx10620\cellx10671\trrh364
\pard\plain\intbl\li22\ri22\sa22\cf1\f52\fs12\ql 6. ISSUED BY\cell\pard\plain\intbl\li22\ri22\sa22\cf1\f52\fs12\qr CODE\cell\pard\plain\intbl\li66\ri22\sb22\sa22\cf1\f51\fs16\ql ASPR-BARDA\cell\pard\plain\intbl\li66\ri22\sb22\cf1\f52\fs12\ql 7. ADMINISTERED BY\plain\intbl\li66\ri22\sa22\cf1\f52\fs12\i\ql (If other than Item 6)
\par\pard\plain\intbl\fs16\cell\pard\plain\intbl\li22\ri22\sa22\cf1\f52\fs12\ql CODE\cell\pard\plain\intbl\li66\ri22\sb22\sa22\cf1\f51\fs16\ql ASPR-BARDA02\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\cellx1749\cellx2952\clbrdrl\brdrs\brdrcf1\clbrdrr\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\cellx4679\cellx7690\cellx8543\clbrdrl\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\cellx10615\clvertalc\cellx10616\clvertalc\cellx10617\clvertalc\cellx10618\clvertalc\cellx10619\clvertalc\cellx10620\cellx10671\trrh364\row}}}
{\trowd\clbrdrr\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\cellx4680\clbrdrb\brdrs\brdrcf1\cellx10617\clvertalc\cellx10618\clvertalc\cellx10619\clvertalc\cellx10620\clvertalc\cellx10621\clvertalc\cellx10622\cellx10673\trrh1190
\pard\plain\intbl\li22\ri22\sb88\sa22\cf1\f51\fs16\ql ASPR-BARDA\par\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs18\ql 200 Independence Ave., S.W.\par\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs18\ql Room 640-G\par\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs18\ql Washington DC 20201
\par\pard\plain\intbl\fs16\cell\pard\plain\intbl\li66\ri22\sb88\sa22\cf1\f51\fs16\ql ASPR-BARDA\par\pard\plain\intbl\li66\ri22\sb22\sa22\cf1\f51\fs18\ql 330 Independence Ave, SW, Rm G640\par\pard\plain\intbl\li66\ri22\sb22\sa22\cf1\f51\fs18\ql Washington DC 20201
\par\pard\plain\intbl\fs16\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clbrdrr\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\cellx4680\clbrdrb\brdrs\brdrcf1\cellx10617\clvertalc\cellx10618\clvertalc\cellx10619\clvertalc\cellx10620\clvertalc\cellx10621\clvertalc\cellx10622\cellx10673\trrh1190\row}}}
{\trowd\cellx4680\clbrdrl\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\cellx5557\clbrdrl\brdrs\brdrcf1\cellx10617\clvertalc\cellx10618\clvertalc\cellx10619\clvertalc\cellx10620\clvertalc\cellx10621\clvertalc\cellx10622\cellx10673\trrh348
\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs12\ql 8. NAME AND ADDRESS OF CONTRACTOR\plain\intbl\li22\ri22\cf1\f52\fs12\i\ql (No., street, county, State and ZIP\plain\intbl\li22\ri22\sa22\cf1\f52\fs12\i\ql Code)\cell\pard\plain\intbl\li22\ri22\sa22\cf1\f51\fs16\qc (x)\cell\pard\plain\intbl\li22\ri22\sa22\cf1\f52\fs12\ql 9A. AMENDMENT OF SOLICITATION NO.\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\cellx4680\clbrdrl\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\cellx5557\clbrdrl\brdrs\brdrcf1\cellx10617\clvertalc\cellx10618\clvertalc\cellx10619\clvertalc\cellx10620\clvertalc\cellx10621\clvertalc\cellx10622\cellx10673\trrh348\row}}}
{\trowd\clvmgf\cellx4680\clbrdrt\brdrs\brdrcf1\clbrdrl\brdrs\brdrcf1\clvertalb\clvmgf\cellx5557\clbrdrl\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10617\clvertalc\cellx10618\clvertalc\cellx10619\clvertalc\cellx10620\clvertalc\cellx10621\clvertalc\cellx10622\cellx10673\trrh281
\par\pard\plain\intbl\fs16\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql CHIMERIX, INC. 1377270\par\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql CHIMERIX, INC. 2505 MERIDIAN P\par\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql 2505 MERIDIAN PKWY STE 340\par\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql DURHAM NC 277135246\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvmgf\cellx4680\clbrdrt\brdrs\brdrcf1\clbrdrl\brdrs\brdrcf1\clvertalb\clvmgf\cellx5557\clbrdrl\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10617\clvertalc\cellx10618\clvertalc\cellx10619\clvertalc\cellx10620\clvertalc\cellx10621\clvertalc\cellx10622\cellx10673\trrh281\row}}}
{\trowd\clvmrg\cellx4680\clbrdrt\brdrs\brdrcf1\clbrdrl\brdrs\brdrcf1\clvertalb\clvmrg\cellx5557\clbrdrt\brdrs\brdrcf1\clbrdrl\brdrs\brdrcf1\cellx10617\clvertalc\cellx10618\clvertalc\cellx10619\clvertalc\cellx10620\clvertalc\cellx10621\clvertalc\cellx10622\clvertalc\cellx10623\clvertalc\cellx10624\clvertalc\cellx10625\clvertalc\cellx10626\clvertalc\cellx10627\clvertalc\cellx10628\clvertalc\cellx10629\cellx10666\trrh216
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\cf1\f52\fs12\ql \~9B. DATED\plain\intbl\li22\ri22\sa22\cf1\f52\fs12\i\ql (SEE ITEM 11)\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvmrg\cellx4680\clbrdrt\brdrs\brdrcf1\clbrdrl\brdrs\brdrcf1\clvertalb\clvmrg\cellx5557\clbrdrt\brdrs\brdrcf1\clbrdrl\brdrs\brdrcf1\cellx10617\clvertalc\cellx10618\clvertalc\cellx10619\clvertalc\cellx10620\clvertalc\cellx10621\clvertalc\cellx10622\clvertalc\cellx10623\clvertalc\cellx10624\clvertalc\cellx10625\clvertalc\cellx10626\clvertalc\cellx10627\clvertalc\cellx10628\clvertalc\cellx10629\cellx10666\trrh216\row}}}
{\trowd\clvmrg\cellx4680\clbrdrl\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\clvertalb\cellx5557\clbrdrl\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10617\clvertalc\cellx10618\clvertalc\cellx10619\clvertalc\cellx10620\clvertalc\cellx10621\clvertalc\cellx10622\clvertalc\cellx10623\clvertalc\cellx10624\clvertalc\cellx10625\clvertalc\cellx10626\clvertalc\cellx10627\clvertalc\cellx10628\clvertalc\cellx10629\clvertalc\cellx10630\clvertalc\cellx10631\clvertalc\cellx10632\clvertalc\cellx10633\clvertalc\cellx10634\cellx10661\trrh304
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvmrg\cellx4680\clbrdrl\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\clvertalb\cellx5557\clbrdrl\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10617\clvertalc\cellx10618\clvertalc\cellx10619\clvertalc\cellx10620\clvertalc\cellx10621\clvertalc\cellx10622\clvertalc\cellx10623\clvertalc\cellx10624\clvertalc\cellx10625\clvertalc\cellx10626\clvertalc\cellx10627\clvertalc\cellx10628\clvertalc\cellx10629\clvertalc\cellx10630\clvertalc\cellx10631\clvertalc\cellx10632\clvertalc\cellx10633\clvertalc\cellx10634\cellx10661\trrh304\row}}}
{\trowd\clvmrg\cellx4680\clbrdrt\brdrs\brdrcf1\clbrdrl\brdrs\brdrcf1\cellx5557\clbrdrt\brdrs\brdrcf1\clbrdrl\brdrs\brdrcf1\clvmgf\cellx10617\clvertalc\cellx10618\clvertalc\cellx10619\clvertalc\cellx10620\clvertalc\cellx10621\clvertalc\cellx10622\clvertalc\cellx10623\clvertalc\cellx10624\clvertalc\cellx10625\clvertalc\cellx10626\clvertalc\cellx10627\clvertalc\cellx10628\clvertalc\cellx10629\clvertalc\cellx10630\clvertalc\cellx10631\clvertalc\cellx10632\clvertalc\cellx10633\clvertalc\cellx10634\clvertalc\cellx10635\clvertalc\cellx10636\clvertalc\cellx10637\clvertalc\cellx10638\clvertalc\cellx10639\cellx10656\trrh232
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sa22\cf1\f51\fs16\qc x\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs12\ql \~10A. MODIFICATION OF CONTRACT/ORDER NO.\par\pard\plain\intbl\li22\ri22\sb88\sa22\cf1\f51\fs20\ql \~HHSO100201100013C\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvmrg\cellx4680\clbrdrt\brdrs\brdrcf1\clbrdrl\brdrs\brdrcf1\cellx5557\clbrdrt\brdrs\brdrcf1\clbrdrl\brdrs\brdrcf1\clvmgf\cellx10617\clvertalc\cellx10618\clvertalc\cellx10619\clvertalc\cellx10620\clvertalc\cellx10621\clvertalc\cellx10622\clvertalc\cellx10623\clvertalc\cellx10624\clvertalc\cellx10625\clvertalc\cellx10626\clvertalc\cellx10627\clvertalc\cellx10628\clvertalc\cellx10629\clvertalc\cellx10630\clvertalc\cellx10631\clvertalc\cellx10632\clvertalc\cellx10633\clvertalc\cellx10634\clvertalc\cellx10635\clvertalc\cellx10636\clvertalc\cellx10637\clvertalc\cellx10638\clvertalc\cellx10639\cellx10656\trrh232\row}}}
{\trowd\clvmrg\cellx4680\clbrdrl\brdrs\brdrcf1\clvertalb\clvmgf\cellx5557\clbrdrt\brdrs\brdrcf1\clbrdrl\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\clvmrg\cellx10617\clvertalc\cellx10618\clvertalc\cellx10619\clvertalc\cellx10620\clvertalc\cellx10621\clvertalc\cellx10622\clvertalc\cellx10623\clvertalc\cellx10624\clvertalc\cellx10625\clvertalc\cellx10626\clvertalc\cellx10627\clvertalc\cellx10628\clvertalc\cellx10629\clvertalc\cellx10630\clvertalc\cellx10631\clvertalc\cellx10632\clvertalc\cellx10633\clvertalc\cellx10634\clvertalc\cellx10635\clvertalc\cellx10636\clvertalc\cellx10637\clvertalc\cellx10638\clvertalc\cellx10639\clvertalc\cellx10640\clvertalc\cellx10641\cellx10654\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvmrg\cellx4680\clbrdrl\brdrs\brdrcf1\clvertalb\clvmgf\cellx5557\clbrdrt\brdrs\brdrcf1\clbrdrl\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\clvmrg\cellx10617\clvertalc\cellx10618\clvertalc\cellx10619\clvertalc\cellx10620\clvertalc\cellx10621\clvertalc\cellx10622\clvertalc\cellx10623\clvertalc\cellx10624\clvertalc\cellx10625\clvertalc\cellx10626\clvertalc\cellx10627\clvertalc\cellx10628\clvertalc\cellx10629\clvertalc\cellx10630\clvertalc\cellx10631\clvertalc\cellx10632\clvertalc\cellx10633\clvertalc\cellx10634\clvertalc\cellx10635\clvertalc\cellx10636\clvertalc\cellx10637\clvertalc\cellx10638\clvertalc\cellx10639\clvertalc\cellx10640\clvertalc\cellx10641\cellx10654\trrh-66\row}}}
{\trowd\clvmrg\cellx4680\clbrdrl\brdrs\brdrcf1\clvertalb\clvmrg\cellx5557\clbrdrt\brdrs\brdrcf1\clbrdrl\brdrs\brdrcf1\clvmgf\cellx10617\clvertalc\cellx10618\clvertalc\cellx10619\clvertalc\cellx10620\clvertalc\cellx10621\clvertalc\cellx10622\clvertalc\cellx10623\clvertalc\cellx10624\clvertalc\cellx10625\clvertalc\cellx10626\clvertalc\cellx10627\clvertalc\cellx10628\clvertalc\cellx10629\clvertalc\cellx10630\clvertalc\cellx10631\clvertalc\cellx10632\clvertalc\cellx10633\clvertalc\cellx10634\clvertalc\cellx10635\clvertalc\cellx10636\clvertalc\cellx10637\clvertalc\cellx10638\clvertalc\cellx10639\clvertalc\cellx10640\clvertalc\cellx10641\clvertalc\cellx10642\clvertalc\cellx10643\clvertalc\cellx10644\clvertalc\cellx10645\clvertalc\cellx10646\clvertalc\cellx10647\clvertalc\cellx10648\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\cf1\f52\fs12\ql \~10B. DATED\plain\intbl\li22\ri22\sa22\cf1\f52\fs12\i\ql (SEE ITEM 13)\par\pard\plain\intbl\li66\ri22\sb110\sa22\cf1\f51\fs20\ql 02/16/2011\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvmrg\cellx4680\clbrdrl\brdrs\brdrcf1\clvertalb\clvmrg\cellx5557\clbrdrt\brdrs\brdrcf1\clbrdrl\brdrs\brdrcf1\clvmgf\cellx10617\clvertalc\cellx10618\clvertalc\cellx10619\clvertalc\cellx10620\clvertalc\cellx10621\clvertalc\cellx10622\clvertalc\cellx10623\clvertalc\cellx10624\clvertalc\cellx10625\clvertalc\cellx10626\clvertalc\cellx10627\clvertalc\cellx10628\clvertalc\cellx10629\clvertalc\cellx10630\clvertalc\cellx10631\clvertalc\cellx10632\clvertalc\cellx10633\clvertalc\cellx10634\clvertalc\cellx10635\clvertalc\cellx10636\clvertalc\cellx10637\clvertalc\cellx10638\clvertalc\cellx10639\clvertalc\cellx10640\clvertalc\cellx10641\clvertalc\cellx10642\clvertalc\cellx10643\clvertalc\cellx10644\clvertalc\cellx10645\clvertalc\cellx10646\clvertalc\cellx10647\clvertalc\cellx10648\trrh-66\row}}}
{\trowd\clbrdrt\brdrs\brdrcf1\clbrdrr\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\cellx2952\clbrdrt\brdrs\brdrcf1\clbrdrr\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\cellx4679\clbrdrl\brdrs\brdrcf1\clbrdrr\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\clvertalb\cellx5556\clbrdrt\brdrs\brdrcf1\clbrdrl\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\clvmrg\cellx10616\clvertalc\cellx10617\clvertalc\cellx10618\clvertalc\cellx10619\clvertalc\cellx10620\clvertalc\cellx10621\clvertalc\cellx10622\clvertalc\cellx10623\clvertalc\cellx10624\clvertalc\cellx10625\clvertalc\cellx10626\clvertalc\cellx10627\clvertalc\cellx10628\clvertalc\cellx10629\clvertalc\cellx10630\clvertalc\cellx10631\clvertalc\cellx10632\clvertalc\cellx10633\clvertalc\cellx10634\clvertalc\cellx10635\clvertalc\cellx10636\clvertalc\cellx10637\clvertalc\cellx10638\clvertalc\cellx10639\clvertalc\cellx10640\clvertalc\cellx10641\clvertalc\cellx10642\clvertalc\cellx10643\clvertalc\cellx10644\clvertalc\cellx10645\clvertalc\cellx10646\clvertalc\cellx10647\trrh439
\pard\plain\intbl\li22\ri22\sb22\cf1\f52\fs12\ql CODE\plain\intbl\li22\ri22\sa22\cf1\f51\fs12\ql \~\par\pard\plain\intbl\li594\ri22\sb22\sa22\cf1\f51\fs18\ql 1377270\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs12\ql FACILITY CODE\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clbrdrt\brdrs\brdrcf1\clbrdrr\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\cellx2952\clbrdrt\brdrs\brdrcf1\clbrdrr\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\cellx4679\clbrdrl\brdrs\brdrcf1\clbrdrr\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\clvertalb\cellx5556\clbrdrt\brdrs\brdrcf1\clbrdrl\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\clvmrg\cellx10616\clvertalc\cellx10617\clvertalc\cellx10618\clvertalc\cellx10619\clvertalc\cellx10620\clvertalc\cellx10621\clvertalc\cellx10622\clvertalc\cellx10623\clvertalc\cellx10624\clvertalc\cellx10625\clvertalc\cellx10626\clvertalc\cellx10627\clvertalc\cellx10628\clvertalc\cellx10629\clvertalc\cellx10630\clvertalc\cellx10631\clvertalc\cellx10632\clvertalc\cellx10633\clvertalc\cellx10634\clvertalc\cellx10635\clvertalc\cellx10636\clvertalc\cellx10637\clvertalc\cellx10638\clvertalc\cellx10639\clvertalc\cellx10640\clvertalc\cellx10641\clvertalc\cellx10642\clvertalc\cellx10643\clvertalc\cellx10644\clvertalc\cellx10645\clvertalc\cellx10646\clvertalc\cellx10647\trrh439\row}}}
{\trowd\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\cellx10618\clvertalc\cellx10619\clvertalc\cellx10620\clvertalc\cellx10621\clvertalc\cellx10622\clvertalc\cellx10623\clvertalc\cellx10624\clvertalc\cellx10625\clvertalc\cellx10626\clvertalc\cellx10627\clvertalc\cellx10628\clvertalc\cellx10629\clvertalc\cellx10630\clvertalc\cellx10631\clvertalc\cellx10632\clvertalc\cellx10633\clvertalc\cellx10634\clvertalc\cellx10635\clvertalc\cellx10636\clvertalc\cellx10637\clvertalc\cellx10638\clvertalc\cellx10639\clvertalc\cellx10640\clvertalc\cellx10641\clvertalc\cellx10642\clvertalc\cellx10643\clvertalc\cellx10644\clvertalc\cellx10645\clvertalc\cellx10646\clvertalc\cellx10647\clvertalc\cellx10648\clvertalc\cellx10649\trrh195
\pard\plain\intbl\li22\ri22\sa22\cf1\f52\fs13\b\qc 11. THIS ITEM ONLY APPLIES TO AMENDMENTS OF SOLICITATIONS\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\cellx10618\clvertalc\cellx10619\clvertalc\cellx10620\clvertalc\cellx10621\clvertalc\cellx10622\clvertalc\cellx10623\clvertalc\cellx10624\clvertalc\cellx10625\clvertalc\cellx10626\clvertalc\cellx10627\clvertalc\cellx10628\clvertalc\cellx10629\clvertalc\cellx10630\clvertalc\cellx10631\clvertalc\cellx10632\clvertalc\cellx10633\clvertalc\cellx10634\clvertalc\cellx10635\clvertalc\cellx10636\clvertalc\cellx10637\clvertalc\cellx10638\clvertalc\cellx10639\clvertalc\cellx10640\clvertalc\cellx10641\clvertalc\cellx10642\clvertalc\cellx10643\clvertalc\cellx10644\clvertalc\cellx10645\clvertalc\cellx10646\clvertalc\cellx10647\clvertalc\cellx10648\clvertalc\cellx10649\trrh195\row}}}
{\trowd\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\cellx10618\clvertalc\cellx10619\clvertalc\cellx10620\clvertalc\cellx10621\clvertalc\cellx10622\clvertalc\cellx10623\clvertalc\cellx10624\clvertalc\cellx10625\clvertalc\cellx10626\clvertalc\cellx10627\clvertalc\cellx10628\clvertalc\cellx10629\clvertalc\cellx10630\clvertalc\cellx10631\clvertalc\cellx10632\clvertalc\cellx10633\clvertalc\cellx10634\clvertalc\cellx10635\clvertalc\cellx10636\clvertalc\cellx10637\clvertalc\cellx10638\clvertalc\cellx10639\clvertalc\cellx10640\clvertalc\cellx10641\clvertalc\cellx10642\clvertalc\cellx10643\clvertalc\cellx10644\clvertalc\cellx10645\clvertalc\cellx10646\clvertalc\cellx10647\clvertalc\cellx10648\clvertalc\cellx10649\trrh1558
\pard\plain\intbl\li198\ri22\sb88\fi-198\cf1\f54\fs24\ql o\plain\intbl\li198\ri22\cf1\f51\fs13\ql \~\~\~\plain\intbl\li198\ri22\cf1\f52\fs13\ql The above numbered solicitation is amended as set forth in Item 14. The hour and date specified for receipt of Offers\plain\intbl\li198\ri22\cf1\f54\fs24\ql o\plain\intbl\li198\ri22\cf1\f52\fs13\ql \~\~is extended.\plain\intbl\li198\ri22\cf1\f54\fs24\ql o\plain\intbl\li198\ri22\sa22\cf1\f52\fs13\ql \~is not extended\par\pard\plain\intbl\li198\ri22\sb22\cf1\f52\fs13\ql Offers must acknowledge receipt of this amendment prior to the hour and date specified in the solicitation or as amended, by one of the following methods: (a) By\plain\intbl\li198\ri22\cf1\f52\fs13\ql completing Items 8 and 15, and returning ___________ copies of the amendment; (b) By acknowledging receipt of this amendment on each copy of the offer submitted; or\plain\intbl\li198\ri22\cf1\f52\fs13\ql (c) By separate letter or telegram which includes a reference to the solicitation and amendment numbers. FAILURE OF YOUR ACKNOWLEDGEMENT TO BE RECEIVED\plain\intbl\li198\ri22\cf1\f52\fs13\ql AT
\par\pard\plain\intbl\fs16\pard\plain\intbl\li198\ri22\cf1\f52\fs13\ql THE PLACE DESIGNATED FOR THE RECEIPT OF OFFERS PRIOR TO THE HOUR AND DATE SPECIFIED MAY RESULT IN REJECTION OF YOUR OFFER. If by
\par\pard\plain\intbl\fs16\pard\plain\intbl\li198\ri22\cf1\f52\fs13\ql virtue of this amendment you desire to change an offer already submitted, such change may be made by telegram or letter, provided each telegram or letter makes
\par\pard\plain\intbl\fs16\pard\plain\intbl\li198\ri22\sa22\cf1\f52\fs13\ql reference to the solicitation and this amendment, and is received prior to the opening hour and date specified.\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\cellx10618\clvertalc\cellx10619\clvertalc\cellx10620\clvertalc\cellx10621\clvertalc\cellx10622\clvertalc\cellx10623\clvertalc\cellx10624\clvertalc\cellx10625\clvertalc\cellx10626\clvertalc\cellx10627\clvertalc\cellx10628\clvertalc\cellx10629\clvertalc\cellx10630\clvertalc\cellx10631\clvertalc\cellx10632\clvertalc\cellx10633\clvertalc\cellx10634\clvertalc\cellx10635\clvertalc\cellx10636\clvertalc\cellx10637\clvertalc\cellx10638\clvertalc\cellx10639\clvertalc\cellx10640\clvertalc\cellx10641\clvertalc\cellx10642\clvertalc\cellx10643\clvertalc\cellx10644\clvertalc\cellx10645\clvertalc\cellx10646\clvertalc\cellx10647\clvertalc\cellx10648\clvertalc\cellx10649\trrh1558\row}}}
{\trowd\clbrdrt\brdrs\brdrcf1\cellx10618\clvertalc\cellx10619\clvertalc\cellx10620\clvertalc\cellx10621\clvertalc\cellx10622\clvertalc\cellx10623\clvertalc\cellx10624\clvertalc\cellx10625\clvertalc\cellx10626\clvertalc\cellx10627\clvertalc\cellx10628\clvertalc\cellx10629\clvertalc\cellx10630\clvertalc\cellx10631\clvertalc\cellx10632\clvertalc\cellx10633\clvertalc\cellx10634\clvertalc\cellx10635\clvertalc\cellx10636\clvertalc\cellx10637\clvertalc\cellx10638\clvertalc\cellx10639\clvertalc\cellx10640\clvertalc\cellx10641\clvertalc\cellx10642\clvertalc\cellx10643\clvertalc\cellx10644\clvertalc\cellx10645\clvertalc\cellx10646\clvertalc\cellx10647\clvertalc\cellx10648\clvertalc\cellx10649\trrh443
\pard\plain\intbl\li22\ri22\sb22\cf1\f52\fs13\ql 12. ACCOUNTING AND APPROPRIATION DATA\plain\intbl\li22\ri22\sa22\cf1\f52\fs13\i\ql (if required)\par\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs16\ql \~N/A.\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clbrdrt\brdrs\brdrcf1\cellx10618\clvertalc\cellx10619\clvertalc\cellx10620\clvertalc\cellx10621\clvertalc\cellx10622\clvertalc\cellx10623\clvertalc\cellx10624\clvertalc\cellx10625\clvertalc\cellx10626\clvertalc\cellx10627\clvertalc\cellx10628\clvertalc\cellx10629\clvertalc\cellx10630\clvertalc\cellx10631\clvertalc\cellx10632\clvertalc\cellx10633\clvertalc\cellx10634\clvertalc\cellx10635\clvertalc\cellx10636\clvertalc\cellx10637\clvertalc\cellx10638\clvertalc\cellx10639\clvertalc\cellx10640\clvertalc\cellx10641\clvertalc\cellx10642\clvertalc\cellx10643\clvertalc\cellx10644\clvertalc\cellx10645\clvertalc\cellx10646\clvertalc\cellx10647\clvertalc\cellx10648\clvertalc\cellx10649\trrh443\row}}}
{\trowd\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\cellx10618\clvertalc\cellx10619\clvertalc\cellx10620\clvertalc\cellx10621\clvertalc\cellx10622\clvertalc\cellx10623\clvertalc\cellx10624\clvertalc\cellx10625\clvertalc\cellx10626\clvertalc\cellx10627\clvertalc\cellx10628\clvertalc\cellx10629\clvertalc\cellx10630\clvertalc\cellx10631\clvertalc\cellx10632\clvertalc\cellx10633\clvertalc\cellx10634\clvertalc\cellx10635\clvertalc\cellx10636\clvertalc\cellx10637\clvertalc\cellx10638\clvertalc\cellx10639\clvertalc\cellx10640\clvertalc\cellx10641\clvertalc\cellx10642\clvertalc\cellx10643\clvertalc\cellx10644\clvertalc\cellx10645\clvertalc\cellx10646\clvertalc\cellx10647\clvertalc\cellx10648\clvertalc\cellx10649\trrh825
\pard\plain\intbl\li22\ri22\sa264\cf1\f52\fs13\b\qc 13. THIS ITEM ONLY APPLIES TO MODIFICATION OF CONTRACTS/ORDERS. IT MODIFIES THE CONTRACT/ORDER NO. AS DESCRIBED IN ITEM 14.\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\cellx10618\clvertalc\cellx10619\clvertalc\cellx10620\clvertalc\cellx10621\clvertalc\cellx10622\clvertalc\cellx10623\clvertalc\cellx10624\clvertalc\cellx10625\clvertalc\cellx10626\clvertalc\cellx10627\clvertalc\cellx10628\clvertalc\cellx10629\clvertalc\cellx10630\clvertalc\cellx10631\clvertalc\cellx10632\clvertalc\cellx10633\clvertalc\cellx10634\clvertalc\cellx10635\clvertalc\cellx10636\clvertalc\cellx10637\clvertalc\cellx10638\clvertalc\cellx10639\clvertalc\cellx10640\clvertalc\cellx10641\clvertalc\cellx10642\clvertalc\cellx10643\clvertalc\cellx10644\clvertalc\cellx10645\clvertalc\cellx10646\clvertalc\cellx10647\clvertalc\cellx10648\clvertalc\cellx10649\trrh825\row}}}
{\trowd\clbrdrr\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\clvertalb\cellx792\clvmgf\cellx10617\clvertalc\cellx10618\clvertalc\cellx10619\clvertalc\cellx10620\clvertalc\cellx10621\clvertalc\cellx10622\clvertalc\cellx10623\clvertalc\cellx10624\clvertalc\cellx10625\clvertalc\cellx10626\clvertalc\cellx10627\clvertalc\cellx10628\clvertalc\cellx10629\clvertalc\cellx10630\clvertalc\cellx10631\clvertalc\cellx10632\clvertalc\cellx10633\clvertalc\cellx10634\clvertalc\cellx10635\clvertalc\cellx10636\clvertalc\cellx10637\clvertalc\cellx10638\clvertalc\cellx10639\clvertalc\cellx10640\clvertalc\cellx10641\clvertalc\cellx10642\clvertalc\cellx10643\clvertalc\cellx10644\clvertalc\cellx10645\clvertalc\cellx10646\clvertalc\cellx10647\clvertalc\cellx10648\trrh158
\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs10\qc CHECK ONE\cell\pard\plain\intbl\li286\ri22\sb22\fi-198\cf1\f52\fs13\ql A. THIS CHANGE ORDER IS ISSUED PURSUANT TO:\plain\intbl\li286\ri22\cf1\f52\fs13\i\ql (Specify authority)\plain\intbl\li286\ri22\cf1\f52\fs13\ql \~\~THE CHANGES SET FORTH IN ITEM 14 ARE MADE IN THE CONTRACT\plain\intbl\li286\ri22\sa22\cf1\f52\fs13\ql ORDER NO. IN ITEM 10A.\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clbrdrr\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\clvertalb\cellx792\clvmgf\cellx10617\clvertalc\cellx10618\clvertalc\cellx10619\clvertalc\cellx10620\clvertalc\cellx10621\clvertalc\cellx10622\clvertalc\cellx10623\clvertalc\cellx10624\clvertalc\cellx10625\clvertalc\cellx10626\clvertalc\cellx10627\clvertalc\cellx10628\clvertalc\cellx10629\clvertalc\cellx10630\clvertalc\cellx10631\clvertalc\cellx10632\clvertalc\cellx10633\clvertalc\cellx10634\clvertalc\cellx10635\clvertalc\cellx10636\clvertalc\cellx10637\clvertalc\cellx10638\clvertalc\cellx10639\clvertalc\cellx10640\clvertalc\cellx10641\clvertalc\cellx10642\clvertalc\cellx10643\clvertalc\cellx10644\clvertalc\cellx10645\clvertalc\cellx10646\clvertalc\cellx10647\clvertalc\cellx10648\trrh158\row}}}
{\trowd\clbrdrt\brdrs\brdrcf1\clbrdrr\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\clvertalb\cellx792\clbrdrb\brdrs\brdrcf1\clvmrg\cellx10617\clvertalc\cellx10618\clvertalc\cellx10619\clvertalc\cellx10620\clvertalc\cellx10621\clvertalc\cellx10622\clvertalc\cellx10623\clvertalc\cellx10624\clvertalc\cellx10625\clvertalc\cellx10626\clvertalc\cellx10627\clvertalc\cellx10628\clvertalc\cellx10629\clvertalc\cellx10630\clvertalc\cellx10631\clvertalc\cellx10632\clvertalc\cellx10633\clvertalc\cellx10634\clvertalc\cellx10635\clvertalc\cellx10636\clvertalc\cellx10637\clvertalc\cellx10638\clvertalc\cellx10639\clvertalc\cellx10640\clvertalc\cellx10641\clvertalc\cellx10642\clvertalc\cellx10643\clvertalc\cellx10644\clvertalc\cellx10645\clvertalc\cellx10646\clvertalc\cellx10647\clvertalc\cellx10648\trrh354
\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clbrdrt\brdrs\brdrcf1\clbrdrr\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\clvertalb\cellx792\clbrdrb\brdrs\brdrcf1\clvmrg\cellx10617\clvertalc\cellx10618\clvertalc\cellx10619\clvertalc\cellx10620\clvertalc\cellx10621\clvertalc\cellx10622\clvertalc\cellx10623\clvertalc\cellx10624\clvertalc\cellx10625\clvertalc\cellx10626\clvertalc\cellx10627\clvertalc\cellx10628\clvertalc\cellx10629\clvertalc\cellx10630\clvertalc\cellx10631\clvertalc\cellx10632\clvertalc\cellx10633\clvertalc\cellx10634\clvertalc\cellx10635\clvertalc\cellx10636\clvertalc\cellx10637\clvertalc\cellx10638\clvertalc\cellx10639\clvertalc\cellx10640\clvertalc\cellx10641\clvertalc\cellx10642\clvertalc\cellx10643\clvertalc\cellx10644\clvertalc\cellx10645\clvertalc\cellx10646\clvertalc\cellx10647\clvertalc\cellx10648\trrh354\row}}}
{\trowd\clbrdrt\brdrs\brdrcf1\clbrdrr\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\clvertalb\cellx792\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\cellx10617\clvertalc\cellx10618\clvertalc\cellx10619\clvertalc\cellx10620\clvertalc\cellx10621\clvertalc\cellx10622\clvertalc\cellx10623\clvertalc\cellx10624\clvertalc\cellx10625\clvertalc\cellx10626\clvertalc\cellx10627\clvertalc\cellx10628\clvertalc\cellx10629\clvertalc\cellx10630\clvertalc\cellx10631\clvertalc\cellx10632\clvertalc\cellx10633\clvertalc\cellx10634\clvertalc\cellx10635\clvertalc\cellx10636\clvertalc\cellx10637\clvertalc\cellx10638\clvertalc\cellx10639\clvertalc\cellx10640\clvertalc\cellx10641\clvertalc\cellx10642\clvertalc\cellx10643\clvertalc\cellx10644\clvertalc\cellx10645\clvertalc\cellx10646\clvertalc\cellx10647\clvertalc\cellx10648\trrh389
\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li286\ri22\sb22\fi-198\cf1\f52\fs13\ql B. THE ABOVE NUMBERED CONTRACT/ORDER IS MODIFIED TO REFLECT THE ADMINISTRATIVE CHANGES (\plain\intbl\li286\ri22\cf1\f52\fs13\i\ql such as changes in paying office,\plain\intbl\li286\ri22\cf1\f52\fs13\i\ql appropriation date, etc.\plain\intbl\li286\ri22\sa22\cf1\f52\fs13\ql ) SET FORTH IN ITEM 14, PURSUANT TO THE AUTHORITY OF FAR 43.103(b).\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clbrdrt\brdrs\brdrcf1\clbrdrr\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\clvertalb\cellx792\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\cellx10617\clvertalc\cellx10618\clvertalc\cellx10619\clvertalc\cellx10620\clvertalc\cellx10621\clvertalc\cellx10622\clvertalc\cellx10623\clvertalc\cellx10624\clvertalc\cellx10625\clvertalc\cellx10626\clvertalc\cellx10627\clvertalc\cellx10628\clvertalc\cellx10629\clvertalc\cellx10630\clvertalc\cellx10631\clvertalc\cellx10632\clvertalc\cellx10633\clvertalc\cellx10634\clvertalc\cellx10635\clvertalc\cellx10636\clvertalc\cellx10637\clvertalc\cellx10638\clvertalc\cellx10639\clvertalc\cellx10640\clvertalc\cellx10641\clvertalc\cellx10642\clvertalc\cellx10643\clvertalc\cellx10644\clvertalc\cellx10645\clvertalc\cellx10646\clvertalc\cellx10647\clvertalc\cellx10648\trrh389\row}}}
{\trowd\clbrdrt\brdrs\brdrcf1\clbrdrr\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\clvertalb\cellx792\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\cellx10617\clvertalc\cellx10618\clvertalc\cellx10619\clvertalc\cellx10620\clvertalc\cellx10621\clvertalc\cellx10622\clvertalc\cellx10623\clvertalc\cellx10624\clvertalc\cellx10625\clvertalc\cellx10626\clvertalc\cellx10627\clvertalc\cellx10628\clvertalc\cellx10629\clvertalc\cellx10630\clvertalc\cellx10631\clvertalc\cellx10632\clvertalc\cellx10633\clvertalc\cellx10634\clvertalc\cellx10635\clvertalc\cellx10636\clvertalc\cellx10637\clvertalc\cellx10638\clvertalc\cellx10639\clvertalc\cellx10640\clvertalc\cellx10641\clvertalc\cellx10642\clvertalc\cellx10643\clvertalc\cellx10644\clvertalc\cellx10645\clvertalc\cellx10646\clvertalc\cellx10647\clvertalc\cellx10648\trrh298
\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li286\ri22\sb22\sa22\fi-198\cf1\f52\fs13\ql C. THIS SUPPLEMENTAL AGREEMENT IS ENTERED INTO PURSUANT TO AUTHORITY OF:\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clbrdrt\brdrs\brdrcf1\clbrdrr\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\clvertalb\cellx792\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\cellx10617\clvertalc\cellx10618\clvertalc\cellx10619\clvertalc\cellx10620\clvertalc\cellx10621\clvertalc\cellx10622\clvertalc\cellx10623\clvertalc\cellx10624\clvertalc\cellx10625\clvertalc\cellx10626\clvertalc\cellx10627\clvertalc\cellx10628\clvertalc\cellx10629\clvertalc\cellx10630\clvertalc\cellx10631\clvertalc\cellx10632\clvertalc\cellx10633\clvertalc\cellx10634\clvertalc\cellx10635\clvertalc\cellx10636\clvertalc\cellx10637\clvertalc\cellx10638\clvertalc\cellx10639\clvertalc\cellx10640\clvertalc\cellx10641\clvertalc\cellx10642\clvertalc\cellx10643\clvertalc\cellx10644\clvertalc\cellx10645\clvertalc\cellx10646\clvertalc\cellx10647\clvertalc\cellx10648\trrh298\row}}}
{\trowd\clbrdrt\brdrs\brdrcf1\clbrdrr\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\clvertalb\cellx792\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\cellx10617\clvertalc\cellx10618\clvertalc\cellx10619\clvertalc\cellx10620\clvertalc\cellx10621\clvertalc\cellx10622\clvertalc\cellx10623\clvertalc\cellx10624\clvertalc\cellx10625\clvertalc\cellx10626\clvertalc\cellx10627\clvertalc\cellx10628\clvertalc\cellx10629\clvertalc\cellx10630\clvertalc\cellx10631\clvertalc\cellx10632\clvertalc\cellx10633\clvertalc\cellx10634\clvertalc\cellx10635\clvertalc\cellx10636\clvertalc\cellx10637\clvertalc\cellx10638\clvertalc\cellx10639\clvertalc\cellx10640\clvertalc\cellx10641\clvertalc\cellx10642\clvertalc\cellx10643\clvertalc\cellx10644\clvertalc\cellx10645\clvertalc\cellx10646\clvertalc\cellx10647\clvertalc\cellx10648\trrh708
\pard\plain\intbl\li22\ri22\sa22\cf1\f51\fs20\qc X\cell\pard\plain\intbl\li286\ri22\sb22\fi-198\cf1\f52\fs13\ql D. OTHER (\plain\intbl\li286\ri22\cf1\f52\fs13\i\ql Specify type of modification and authority\plain\intbl\li286\ri22\sa22\cf1\f52\fs13\ql )\par\pard\plain\intbl\li286\ri22\sb22\sa22\fi-198\cf1\f51\fs20\ql Bilateral: Mutual Agreement of the Parties.
\par\pard\plain\intbl\fs16\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clbrdrt\brdrs\brdrcf1\clbrdrr\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\clvertalb\cellx792\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\cellx10617\clvertalc\cellx10618\clvertalc\cellx10619\clvertalc\cellx10620\clvertalc\cellx10621\clvertalc\cellx10622\clvertalc\cellx10623\clvertalc\cellx10624\clvertalc\cellx10625\clvertalc\cellx10626\clvertalc\cellx10627\clvertalc\cellx10628\clvertalc\cellx10629\clvertalc\cellx10630\clvertalc\cellx10631\clvertalc\cellx10632\clvertalc\cellx10633\clvertalc\cellx10634\clvertalc\cellx10635\clvertalc\cellx10636\clvertalc\cellx10637\clvertalc\cellx10638\clvertalc\cellx10639\clvertalc\cellx10640\clvertalc\cellx10641\clvertalc\cellx10642\clvertalc\cellx10643\clvertalc\cellx10644\clvertalc\cellx10645\clvertalc\cellx10646\clvertalc\cellx10647\clvertalc\cellx10648\trrh708\row}}}
{\trowd\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\cellx10618\clvertalc\cellx10619\clvertalc\cellx10620\clvertalc\cellx10621\clvertalc\cellx10622\clvertalc\cellx10623\clvertalc\cellx10624\clvertalc\cellx10625\clvertalc\cellx10626\clvertalc\cellx10627\clvertalc\cellx10628\clvertalc\cellx10629\clvertalc\cellx10630\clvertalc\cellx10631\clvertalc\cellx10632\clvertalc\cellx10633\clvertalc\cellx10634\clvertalc\cellx10635\clvertalc\cellx10636\clvertalc\cellx10637\clvertalc\cellx10638\clvertalc\cellx10639\clvertalc\cellx10640\clvertalc\cellx10641\clvertalc\cellx10642\clvertalc\cellx10643\clvertalc\cellx10644\clvertalc\cellx10645\clvertalc\cellx10646\clvertalc\cellx10647\clvertalc\cellx10648\clvertalc\cellx10649\trrh364
\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs13\b\ql E. IMPORTANT:\plain\intbl\li22\ri22\cf1\f52\fs13\ql Contractor\plain\intbl\li22\ri22\cf1\f54\fs24\ql o\plain\intbl\li22\ri22\cf1\f52\fs13\ql \~\~is not.\plain\intbl\li22\ri22\cf1\f54\fs24\ql x\plain\intbl\li22\ri22\cf1\f52\fs13\ql \~\~is required to sign this document and return\plain\intbl\li22\ri22\cf1\f52\fs13\ql \~\~\~\~\~\~\~\~\~\~\~\plain\intbl\li22\ri22\cf1\f51\fs16\ql 0\plain\intbl\li22\ri22\cf1\f52\fs13\ql \~\~\~\plain\intbl\li22\ri22\sa22\cf1\f52\fs13\ql \~copies to the issuing office.\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
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\pard\plain\intbl\li22\ri22\sb22\cf1\f52\fs13\ql 14. DESCRIPTION OF AMENDMENT/MODIFICATION\plain\intbl\li22\ri22\sa22\cf1\f52\fs13\i\ql (Organized by UCF section headings, including solicitation/contract subject matter where feasible.)\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clbrdrt\brdrs\brdrcf1\cellx10618\clvertalc\cellx10619\clvertalc\cellx10620\clvertalc\cellx10621\clvertalc\cellx10622\clvertalc\cellx10623\clvertalc\cellx10624\clvertalc\cellx10625\clvertalc\cellx10626\clvertalc\cellx10627\clvertalc\cellx10628\clvertalc\cellx10629\clvertalc\cellx10630\clvertalc\cellx10631\clvertalc\cellx10632\clvertalc\cellx10633\clvertalc\cellx10634\clvertalc\cellx10635\clvertalc\cellx10636\clvertalc\cellx10637\clvertalc\cellx10638\clvertalc\cellx10639\clvertalc\cellx10640\clvertalc\cellx10641\clvertalc\cellx10642\clvertalc\cellx10643\clvertalc\cellx10644\clvertalc\cellx10645\clvertalc\cellx10646\clvertalc\cellx10647\clvertalc\cellx10648\clvertalc\cellx10649\trrh228\row}}}
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\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs18\ql Tax ID Number: 33-0903395\par\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs18\ql DUNS Number: 121785997\par\pard\plain\intbl\li22\ri22\sb22\cf1\f51\fs18\ql A. The purpose of this modification is for the Government and the Contractor to bilaterally modify the Statement of Work requirements for\plain\intbl\li22\ri22\cf1\f51\fs18\ql Option 2/CLIN 0003 for the purposes of adding within scope changes to the Statement of Work for [\u8230?***\u8230?] studies and\plain\intbl\li22\ri22\sa132\cf1\f51\fs18\ql [\u8230?***\u8230?] to be used in [\u8230?***\u8230?] studies in order to comply with recent FDA guidance.\par\pard\plain\intbl\li22\ri22\sb22\cf1\f51\fs18\ql 1. As a result, Attachment 1, Statement of Work dated 27 October 2014, under PART III, LIST OF DOCUMENTS, EXHIBITS AND\plain\intbl\li22\ri22\cf1\f51\fs18\ql OTHER ATTACHMENTS, SECTION J - LIST OF ATTACHMENTS is hereby deleted and replaced with the attached Statement of Work\plain\intbl\li22\ri22\sa132\cf1\f51\fs18\ql dated 20 August 2015. The\par\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs18\ql Continued ...\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
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\pard\plain\intbl\li22\ri22\sa22\cf1\f52\fs11\b\ql Except as provided herein, all terms and conditions of the document referenced in Item 9A or 10A, as heretofore changed, remains unchanged and in full force and effect.\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
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{\trowd\clbrdrt\brdrs\brdrcf1\clbrdrr\brdrs\brdrcf1\cellx5118\clbrdrt\brdrs\brdrcf1\cellx10617\clvertalc\cellx10618\clvertalc\cellx10619\clvertalc\cellx10620\clvertalc\cellx10621\clvertalc\cellx10622\clvertalc\cellx10623\clvertalc\cellx10624\clvertalc\cellx10625\clvertalc\cellx10626\clvertalc\cellx10627\clvertalc\cellx10628\clvertalc\cellx10629\clvertalc\cellx10630\clvertalc\cellx10631\clvertalc\cellx10632\clvertalc\cellx10633\clvertalc\cellx10634\clvertalc\cellx10635\clvertalc\cellx10636\clvertalc\cellx10637\clvertalc\cellx10638\clvertalc\cellx10639\clvertalc\cellx10640\clvertalc\cellx10641\clvertalc\cellx10642\clvertalc\cellx10643\clvertalc\cellx10644\clvertalc\cellx10645\clvertalc\cellx10646\clvertalc\cellx10647\clvertalc\cellx10648\trrh228
\pard\plain\intbl\li22\ri22\sb22\cf1\f52\fs13\ql 15A. NAME AND TITLE OF SIGNER\plain\intbl\li22\ri22\sa22\cf1\f52\fs13\i\ql (Type or print)\cell\pard\plain\intbl\li22\ri22\sb22\cf1\f52\fs13\ql \~16A. NAME AND TITLE OF CONTRACTING OFFICER\plain\intbl\li22\ri22\sa22\cf1\f52\fs13\i\ql (Type or print)\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clbrdrt\brdrs\brdrcf1\clbrdrr\brdrs\brdrcf1\cellx5118\clbrdrt\brdrs\brdrcf1\cellx10617\clvertalc\cellx10618\clvertalc\cellx10619\clvertalc\cellx10620\clvertalc\cellx10621\clvertalc\cellx10622\clvertalc\cellx10623\clvertalc\cellx10624\clvertalc\cellx10625\clvertalc\cellx10626\clvertalc\cellx10627\clvertalc\cellx10628\clvertalc\cellx10629\clvertalc\cellx10630\clvertalc\cellx10631\clvertalc\cellx10632\clvertalc\cellx10633\clvertalc\cellx10634\clvertalc\cellx10635\clvertalc\cellx10636\clvertalc\cellx10637\clvertalc\cellx10638\clvertalc\cellx10639\clvertalc\cellx10640\clvertalc\cellx10641\clvertalc\cellx10642\clvertalc\cellx10643\clvertalc\cellx10644\clvertalc\cellx10645\clvertalc\cellx10646\clvertalc\cellx10647\clvertalc\cellx10648\trrh228\row}}}
{\trowd\clbrdrr\brdrs\brdrcf1\clvertalb\cellx5118\cellx10617\clvertalc\cellx10618\clvertalc\cellx10619\clvertalc\cellx10620\clvertalc\cellx10621\clvertalc\cellx10622\clvertalc\cellx10623\clvertalc\cellx10624\clvertalc\cellx10625\clvertalc\cellx10626\clvertalc\cellx10627\clvertalc\cellx10628\clvertalc\cellx10629\clvertalc\cellx10630\clvertalc\cellx10631\clvertalc\cellx10632\clvertalc\cellx10633\clvertalc\cellx10634\clvertalc\cellx10635\clvertalc\cellx10636\clvertalc\cellx10637\clvertalc\cellx10638\clvertalc\cellx10639\clvertalc\cellx10640\clvertalc\cellx10641\clvertalc\cellx10642\clvertalc\cellx10643\clvertalc\cellx10644\clvertalc\cellx10645\clvertalc\cellx10646\clvertalc\cellx10647\clvertalc\cellx10648\trrh363
\pard\plain\intbl\li198\ri22\sb22\sa22\cf1\f51\fs18\ql MICHAEL D. ROGERS, CDO\cell\pard\plain\intbl\li66\ri22\sb88\cf1\f51\fs18\ql ETHAN J. MUELLER\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clbrdrr\brdrs\brdrcf1\clvertalb\cellx5118\cellx10617\clvertalc\cellx10618\clvertalc\cellx10619\clvertalc\cellx10620\clvertalc\cellx10621\clvertalc\cellx10622\clvertalc\cellx10623\clvertalc\cellx10624\clvertalc\cellx10625\clvertalc\cellx10626\clvertalc\cellx10627\clvertalc\cellx10628\clvertalc\cellx10629\clvertalc\cellx10630\clvertalc\cellx10631\clvertalc\cellx10632\clvertalc\cellx10633\clvertalc\cellx10634\clvertalc\cellx10635\clvertalc\cellx10636\clvertalc\cellx10637\clvertalc\cellx10638\clvertalc\cellx10639\clvertalc\cellx10640\clvertalc\cellx10641\clvertalc\cellx10642\clvertalc\cellx10643\clvertalc\cellx10644\clvertalc\cellx10645\clvertalc\cellx10646\clvertalc\cellx10647\clvertalc\cellx10648\trrh363\row}}}
{\trowd\clbrdrt\brdrs\brdrcf1\clbrdrr\brdrs\brdrcf1\cellx3487\clbrdrt\brdrs\brdrcf1\clbrdrr\brdrs\brdrcf1\cellx5117\clbrdrt\brdrs\brdrcf1\clbrdrr\brdrs\brdrcf1\cellx9173\clbrdrt\brdrs\brdrcf1\cellx10615\clvertalc\cellx10616\clvertalc\cellx10617\clvertalc\cellx10618\clvertalc\cellx10619\clvertalc\cellx10620\clvertalc\cellx10621\clvertalc\cellx10622\clvertalc\cellx10623\clvertalc\cellx10624\clvertalc\cellx10625\clvertalc\cellx10626\clvertalc\cellx10627\clvertalc\cellx10628\clvertalc\cellx10629\clvertalc\cellx10630\clvertalc\cellx10631\clvertalc\cellx10632\clvertalc\cellx10633\clvertalc\cellx10634\clvertalc\cellx10635\clvertalc\cellx10636\clvertalc\cellx10637\clvertalc\cellx10638\clvertalc\cellx10639\clvertalc\cellx10640\clvertalc\cellx10641\clvertalc\cellx10642\clvertalc\cellx10643\clvertalc\cellx10644\clvertalc\cellx10645\clvertalc\cellx10646\trrh195
\pard\plain\intbl\li22\ri22\sa22\cf1\f52\fs13\ql 15B. CONTRACTOR/OFFEROR\cell\pard\plain\intbl\li22\ri22\sa22\cf1\f52\fs13\ql 15C. DATE SIGNED\cell\pard\plain\intbl\li22\ri22\sa22\cf1\f52\fs13\ql 16B. UNITED STATES OF AMERICA\cell\pard\plain\intbl\li22\ri22\sa22\cf1\f52\fs13\ql 16C. DATE SIGNED\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clbrdrt\brdrs\brdrcf1\clbrdrr\brdrs\brdrcf1\cellx3487\clbrdrt\brdrs\brdrcf1\clbrdrr\brdrs\brdrcf1\cellx5117\clbrdrt\brdrs\brdrcf1\clbrdrr\brdrs\brdrcf1\cellx9173\clbrdrt\brdrs\brdrcf1\cellx10615\clvertalc\cellx10616\clvertalc\cellx10617\clvertalc\cellx10618\clvertalc\cellx10619\clvertalc\cellx10620\clvertalc\cellx10621\clvertalc\cellx10622\clvertalc\cellx10623\clvertalc\cellx10624\clvertalc\cellx10625\clvertalc\cellx10626\clvertalc\cellx10627\clvertalc\cellx10628\clvertalc\cellx10629\clvertalc\cellx10630\clvertalc\cellx10631\clvertalc\cellx10632\clvertalc\cellx10633\clvertalc\cellx10634\clvertalc\cellx10635\clvertalc\cellx10636\clvertalc\cellx10637\clvertalc\cellx10638\clvertalc\cellx10639\clvertalc\cellx10640\clvertalc\cellx10641\clvertalc\cellx10642\clvertalc\cellx10643\clvertalc\cellx10644\clvertalc\cellx10645\clvertalc\cellx10646\trrh195\row}}}
{\trowd\clbrdrr\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\cellx3487\clbrdrr\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\clvertalc\cellx5117\clbrdrr\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\cellx9173\clbrdrb\brdrs\brdrcf1\clvertalc\cellx10615\clvertalc\cellx10616\clvertalc\cellx10617\clvertalc\cellx10618\clvertalc\cellx10619\clvertalc\cellx10620\clvertalc\cellx10621\clvertalc\cellx10622\clvertalc\cellx10623\clvertalc\cellx10624\clvertalc\cellx10625\clvertalc\cellx10626\clvertalc\cellx10627\clvertalc\cellx10628\clvertalc\cellx10629\clvertalc\cellx10630\clvertalc\cellx10631\clvertalc\cellx10632\clvertalc\cellx10633\clvertalc\cellx10634\clvertalc\cellx10635\clvertalc\cellx10636\clvertalc\cellx10637\clvertalc\cellx10638\clvertalc\cellx10639\clvertalc\cellx10640\clvertalc\cellx10641\clvertalc\cellx10642\clvertalc\cellx10643\clvertalc\cellx10644\clvertalc\cellx10645\clvertalc\cellx10646\trrh0
\pard\plain\intbl\li22\ri22\sb110\cf1\f51\fs16\ql \~\~\~/s/ Michael D. Rogers\plain\intbl\li22\ri22\sa22\cf1\f51\fs18\ql \~\~\~\par\pard\plain\intbl\li22\ri22\sb22\cf1\f51\fs13\i\ql \~\~\~\~\~\~\~\plain\intbl\li22\ri22\sa22\cf1\f52\fs13\i\ql (Signature of person authorized to sign)\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs16\qc 8/31/2015\cell\pard\plain\intbl\li22\ri22\sb110\cf1\f51\fs16\ql \~\~\~\plain\intbl\li22\ri22\cf1\f51\fs16\ql /s/ Ethan J. Mueller\plain\intbl\li22\ri22\cf1\f51\fs18\ql \~\~\~\plain\intbl\li22\ri22\sa22\cf1\f52\fs13\i\ql \~\par\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs13\i\ql \~\~\~\~\~\~\~\~\~\~\~\~\~(Signature of Contracting Officer)\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs16\qc 9/1/2015\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clbrdrr\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\cellx3487\clbrdrr\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\clvertalc\cellx5117\clbrdrr\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\cellx9173\clbrdrb\brdrs\brdrcf1\clvertalc\cellx10615\clvertalc\cellx10616\clvertalc\cellx10617\clvertalc\cellx10618\clvertalc\cellx10619\clvertalc\cellx10620\clvertalc\cellx10621\clvertalc\cellx10622\clvertalc\cellx10623\clvertalc\cellx10624\clvertalc\cellx10625\clvertalc\cellx10626\clvertalc\cellx10627\clvertalc\cellx10628\clvertalc\cellx10629\clvertalc\cellx10630\clvertalc\cellx10631\clvertalc\cellx10632\clvertalc\cellx10633\clvertalc\cellx10634\clvertalc\cellx10635\clvertalc\cellx10636\clvertalc\cellx10637\clvertalc\cellx10638\clvertalc\cellx10639\clvertalc\cellx10640\clvertalc\cellx10641\clvertalc\cellx10642\clvertalc\cellx10643\clvertalc\cellx10644\clvertalc\cellx10645\clvertalc\cellx10646\trrh0\row}}}
\par\pard\plain\fs16\pard\plain\li88\cf1\f52\fs13\ql NSN 7540-01-152-8070\~\~\~\~STANDARD FORM 30 (REV. 10-83)\par\pard\plain\li88\cf1\f52\fs13\ql Previous edition unusable\~\~\~\~Prescribed by GSA\par\pard\plain\fi8778\cf1\f52\fs13\ql FAR (48 CFR) 53.243
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs16\b\qr ***Confidential Treatment Requested
\par\pard\plain\fs16\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par
\page
\par\pard\plain\fs16
\par\pard\plain\fs16
\par\pard\plain\fs16
\par\pard\plain\fs16
\par\pard\plain
{\trowd\clvertalc\cellx10656\cellx10659\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx10656\cellx10659\trrh-66\row}}}
{\trowd\clvertalc\cellx848\clvertalc\cellx2540\clvertalc\cellx5800\clvertalc\cellx6544\clvertalc\cellx6968\clvertalc\cellx8022\clvertalc\cellx9285\clvertalc\cellx9811\clvertalc\cellx10652\cellx10655\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx848\clvertalc\cellx2540\clvertalc\cellx5800\clvertalc\cellx6544\clvertalc\cellx6968\clvertalc\cellx8022\clvertalc\cellx9285\clvertalc\cellx9811\clvertalc\cellx10652\cellx10655\trrh-66\row}}}
{\trowd\clbrdrt\brdrs\brdrcf1\clbrdrr\brdrs\brdrcf12\clvertalc\clvmgf\cellx2540\clbrdrt\brdrs\brdrcf1\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clvmgf\cellx9287\clbrdrt\brdrs\brdrcf1\clbrdrl\brdrs\brdrcf12\cellx10654\cellx10657\trrh216
\pard\plain\intbl\li286\ri22\sb22\sa22\cf1\f52\fs15\b\ql CONTINUATION SHEET\cell\pard\plain\intbl\li132\ri22\sb22\sa22\fi-154\cf1\f52\fs12\ql REFERENCE NO. OF DOCUMENT BEING CONTINUED\par\pard\plain\intbl\li132\ri22\sb22\sa22\fi-154\cf1\f51\fs18\ql HHSO100201100013C/0028\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs12\ql PAGE OF\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clbrdrt\brdrs\brdrcf1\clbrdrr\brdrs\brdrcf12\clvertalc\clvmgf\cellx2540\clbrdrt\brdrs\brdrcf1\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clvmgf\cellx9287\clbrdrt\brdrs\brdrcf1\clbrdrl\brdrs\brdrcf12\cellx10654\cellx10657\trrh216\row}}}
{\trowd\clbrdrt\brdrs\brdrcf1\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf1\clvertalc\clvmrg\cellx2540\clbrdrt\brdrs\brdrcf1\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf1\clvmrg\cellx9287\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf1\cellx9813\clbrdrl\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf1\cellx10654\clvertalc\cellx10655\clvertalc\cellx10656\trrh257
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs18\qc 2\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs18\qr 23\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clbrdrt\brdrs\brdrcf1\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf1\clvertalc\clvmrg\cellx2540\clbrdrt\brdrs\brdrcf1\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf1\clvmrg\cellx9287\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf1\cellx9813\clbrdrl\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf1\cellx10654\clvertalc\cellx10655\clvertalc\cellx10656\trrh257\row}}}
{\trowd\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\cellx10656\clvertalc\cellx10657\clvertalc\cellx10658\trrh456
\pard\plain\intbl\li132\ri22\sb22\sa22\fi-154\cf1\f52\fs12\ql NAME OF OFFEROR OR CONTACTOR\par\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs18\ql CHIMERIX, INC. 1377270\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\cellx10656\clvertalc\cellx10657\clvertalc\cellx10658\trrh456\row}}}
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\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs12\qc ITEM NO.\par\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs16\qc (A)\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs12\qc SUPPLIES/SERVICES\par\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs16\qc (B)\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs12\qc QUANTITY\par\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs16\qc (C)\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs12\qc UNIT\par\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs16\qc (D)\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs12\qc UNIT PRICE\par\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs16\qc (E)\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs12\qc AMOUNT\par\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs16\qc (F)\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
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\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li990\ri22\sb2112\cf1\f51\fs18\ql efforts within Option 2/CLIN 0003 that involve\plain\intbl\li990\ri22\cf1\f51\fs18\ql [\u8230?***\u8230?] and [\u8230?***\u8230?]\plain\intbl\li990\ri22\cf1\f51\fs18\ql cannot be performed until the receipt and approval\plain\intbl\li990\ri22\cf1\f51\fs18\ql of all required Protocols by BARDA inclusive of all\plain\intbl\li990\ri22\cf1\f51\fs18\ql IRB, OHRP approvals and any required Ethics\plain\intbl\li990\ri22\cf1\f51\fs18\ql Approvals for any clinical trials/studies and any\plain\intbl\li990\ri22\cf1\f51\fs18\ql required approved OLAW Assurances and IIA\plain\intbl\li990\ri22\cf1\f51\fs18\ql approvals from OLAW for any non clinical animal\plain\intbl\li990\ri22\sa264\cf1\f51\fs18\ql studies.\par\pard\plain\intbl\li990\ri22\sb22\cf1\f51\fs18\ql 2. The incorporation of the attached Statement of\plain\intbl\li990\ri22\cf1\f51\fs18\ql Work (SOW) changes in the paragraph above also\plain\intbl\li990\ri22\cf1\f51\fs18\ql result in the incorporation of the attached changes\plain\intbl\li990\ri22\cf1\f51\fs18\ql into the contract into WBS Milestones/Deliverables\plain\intbl\li990\ri22\cf1\f51\fs18\ql and Technical Deliverables and Contract Milestones\plain\intbl\li990\ri22\cf1\f51\fs18\ql and Go/No Go Decision Gates dated 20 August 20l5\plain\intbl\li990\ri22\sa264\cf1\f51\fs18\ql under Article F.2. Deliverables.\par\pard\plain\intbl\li990\ri22\sb22\cf1\f51\fs18\ql 3. The total amount, scope and period of\plain\intbl\li990\ri22\cf1\f51\fs18\ql performance of Option 2/CLIN 0003 remains\plain\intbl\li990\ri22\cf1\f51\fs18\ql unchanged. The total amount, scope and period of\plain\intbl\li990\ri22\cf1\f51\fs18\ql performance of all other CLINs that are currently\plain\intbl\li990\ri22\cf1\f51\fs18\ql being performed under the contract remain\plain\intbl\li990\ri22\cf1\f51\fs18\ql unchanged. This modification does not exercise any\plain\intbl\li990\ri22\cf1\f51\fs18\ql unexercised Option CLINs under the contract and\plain\intbl\li990\ri22\cf1\f51\fs18\ql does not authorize any performance of efforts under\plain\intbl\li990\ri22\cf1\f51\fs18\ql any unexercised Option CLINs under the contract. In\plain\intbl\li990\ri22\cf1\f51\fs18\ql addition, the total amount, scope and period of\plain\intbl\li990\ri22\cf1\f51\fs18\ql performance of all unexercised Option CLINs under\plain\intbl\li990\ri22\sa264\cf1\f51\fs18\ql the contract remain unchanged.\par\pard\plain\intbl\li990\ri22\sb22\cf1\f51\fs18\ql B. This is a no cost bilateral modification. All other\plain\intbl\li990\ri22\cf1\f51\fs18\ql terms and conditions of the contract remain\plain\intbl\li990\ri22\sa22\cf1\f51\fs18\ql unchanged.\par\pard\plain\intbl\li990\ri22\sb22\sa264\cf1\f51\fs18\ql Period of Performance: 02/16/2011 to 06/30/2016
\par\pard\plain\intbl\fs16
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\par\pard\plain\fs16
\par\pard\plain\fs16\pard\plain\sb44\cf1\f52\fs13\ql NSN 7540-01-152-8067\~\~\~\~OPTIONAL FORM 336 (4-86)\par\pard\plain\fi8778\cf1\f52\fs13\ql Sponsored by GSA\par\pard\plain\fi8778\cf1\f52\fs13\ql FAR (48 CFR) 53.110
\par\pard\plain\fs16
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs16\b\qr ***Confidential Treatment Requested
\par\pard\plain\fs16\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par
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\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs32\b\qc BARDA Broad Agency Announcement (BAA)\par\pard\plain\cf1\f51\fs32\b\qc (CBRN-BAA-10-100-SOL-00012)\par\pard\plain\cf1\f51\fs24\qc Advanced Research and Development of Chemical, Biological, Radiological, and\par\pard\plain\cf1\f51\fs24\qc Nuclear Medical Countermeasures\par\pard\plain\cf1\f51\fs24\b\qc DEVELOPMENT OF CMX-001 FOR THE TREATMENT OF SMALLPOX\par\pard\plain\sa264\cf1\f51\fs24\b\qc Topical Area of Interest No. 3, Antimicrobial Drugs\par\pard\plain\sa264\cf1\f51\fs24\b\qc Contractual Statement of Work
\par\pard\plain
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\pard\plain\intbl\cf1\f51\fs20\ql 1.\cell\pard\plain\intbl\cf1\f51\fs24\b\qj PREAMBLE\cell{
{\trowd\cellx170\cellx1572\trrh297\row}}}\pard\plain\cf1\f51\fs24\qj Independently and not as an agency of the Government, the Contractor shall be required to furnish all the\plain\cf1\f51\fs24\qj necessary services, qualified personnel, material, equipment, and facilities, not otherwise provided by the\plain\cf1\f51\fs24\qj Government, as needed to perform the Statement of Work submitted in response to the BARDA Broad\plain\sa264\cf1\f51\fs24\qj Agency Announcement (BAA) CBRN-BAA-10-100-SOL-00012.\par\pard\plain\cf1\f51\fs24\qj In accordance with FAR 52.243-2, Changes-Cost Reimbursement (Alt. V), the Government reserves the\plain\cf1\f51\fs24\qj right to modify the milestones, progress, schedule, budget, or to add or delete deliverables, process, or\plain\cf1\f51\fs24\qj schedules if the need arises. Because of the nature of this research and development (R&D) contract and the\plain\cf1\f51\fs24\qj complexities inherent in this and prior programs, at designated milestones the Government will evaluate\plain\sa264\cf1\f51\fs24\qj whether work should be redirected, removed, or whether schedule or budget adjustments should be made.\par\pard\plain\cf1\f51\fs24\b\qj 1.0\plain\cf1\f51\fs20\qj \~\~\~\~\plain\sa264\cf1\f51\fs24\b\qj Overall Objectives and Scope\par\pard\plain\cf1\f51\fs24\qj The overall objective of this contract is to advance the development of CMX-001 as a broad-spectrum\plain\cf1\f51\fs24\qj therapeutic antiviral for the treatment of smallpox infections and dsDNA viruses. The scope of work for this\plain\cf1\f51\fs24\qj contract includes preclinical, clinical and manufacturing development activities that fall into the following\plain\cf1\f51\fs24\qj areas: non-clinical efficacy studies; clinical activities; manufacturing activities; and all associated regulatory,\plain\cf1\f51\fs24\qj quality assurance, management, and administrative activities. The Research and Development (R&D) effort\plain\cf1\f51\fs24\qj for the antiviral will progress in specific stages that cover the base performance segment and four (4) option\plain\cf1\f51\fs24\qj segments as specified in this contract. The Contractor must complete specific tasks required in each of the\plain\cf1\f51\fs24\qj five discrete work segments. The scope of work has been broken into the following five phases which are\plain\cf1\f51\fs24\qj discrete work segments:
\par\pard\plain
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\pard\plain\intbl\li792\cf1\f51\fs20\ql I.\cell\pard\plain\intbl\cf1\f51\fs24\ql [\u8230?***\u8230?]\cell{
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\pard\plain\intbl\li792\cf1\f51\fs20\ql IV.\cell\pard\plain\intbl\cf1\f51\fs24\ql [\u8230?***\u8230?]\cell{
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\par\pard\plain\fs16
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs16\b\qr ***Confidential Treatment Requested
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\par\pard\plain\fs16
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\pard\plain\intbl\cf1\f51\fs24\b\ql 2.\cell\pard\plain\intbl\cf1\f51\fs24\b\ql PHASE I:\plain\intbl\cf1\f51\fs24\b\ql [\plain\intbl\cf1\f51\fs24\ql \u8230?***\u8230?\plain\intbl\cf1\f51\fs24\b\ql ]\cell{
{\trowd\cellx226\cellx3147\trrh594\row}}}\pard\plain\li396\cf1\f51\fs24\qj Research and development of CMX-001 for the treatment of smallpox and dsDNA viruses to include the\plain\li396\cf1\f51\fs24\qj following activities: [\u8230?***\u8230?].The contractor shall carry out the following tasks and subtasks\plain\li396\cf1\f51\fs24\qj and in accordance with an agreed upon Integrated Master Schedule and Integrated Master Plan (defined\plain\li396\sa264\cf1\f51\fs24\qj in 2.1.8 and 2.1.9 below) which shall further detail the conduct of the specific tasks and subtasks.
\par\pard\plain
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\pard\plain\intbl\cf1\f51\fs24\b\ql 2.1\cell\pard\plain\intbl\li88\fi-88\cf1\f51\fs24\b\qj Program\plain\intbl\li88\cf1\f51\fs24\b\qj Management\cell{
{\trowd\cellx363\cellx2408\trrh864\row}}}\pard\plain\sa264\cf1\f51\fs24\qj The Contractor shall provide for the following as outlined below and in the contract deliverables list (Article\plain\sa264\cf1\f51\fs24\qj F.2):
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\pard\plain\intbl\li396\cf1\f51\fs24\ql 2.1.1\cell\pard\plain\intbl\li396\fi-396\cf1\f51\fs24\ql The overall management, integration and coordination of all contract activities, including a technical\plain\intbl\li396\cf1\f51\fs24\ql and administrative infrastructure to ensure the efficient planning, initiation, implementation, and\plain\intbl\li396\cf1\f51\fs24\ql direction of all contract activities;\cell{
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\pard\plain\intbl\li396\cf1\f51\fs24\ql 2.1.2\cell\pard\plain\intbl\li396\fi-396\cf1\f51\fs24\ql A Principal Investigator (PI) responsible for project management, communication, tracking,\plain\intbl\li396\cf1\f51\fs24\ql monitoring and reporting on status and progress, and modification to the project requirements and\plain\intbl\li396\cf1\f51\fs24\ql timelines, including projects undertaken by subcontractors; The contract deliverables list\plain\intbl\li396\cf1\f51\fs24\ql (reference), identifies all contract deliverables and reporting requirements for this contract.\cell{
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\pard\plain\intbl\li396\cf1\f51\fs24\ql 2.1.3\cell\pard\plain\intbl\li396\fi-396\cf1\f51\fs24\ql Project Manager(s) with responsibility for monitoring and tracking day-to-day progress and\plain\intbl\li396\cf1\f51\fs24\ql timelines, coordinating communication and project activities; costs incurred; and program\plain\intbl\li396\cf1\f51\fs24\ql management; The contract deliverables list (reference), identifies all contract deliverables and\plain\intbl\li396\cf1\f51\fs24\ql reporting requirements for this contract.\cell{
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\pard\plain\intbl\li396\cf1\f51\fs24\ql 2.1.4\cell\pard\plain\intbl\li396\fi-396\cf1\f51\fs24\ql A BARDA Liaison with responsibility for effective communication with the Project Officer and\plain\intbl\li396\cf1\f51\fs24\ql Contracting Officer.\cell{
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\pard\plain\intbl\li396\cf1\f51\fs24\ql 2.1.5\cell\pard\plain\intbl\li396\fi-396\cf1\f51\fs24\ql Administrative and legal staff to provide development of compliant subcontracts, consulting,\plain\intbl\li396\cf1\f51\fs24\ql and other legal agreements, and ensure timely acquisition of all proprietary rights,\plain\intbl\li396\cf1\f51\fs24\ql including IP rights, and reporting all inventions made in the performance of the project.\cell{
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\pard\plain\intbl\li396\cf1\f51\fs24\ql 2.1.6\cell\pard\plain\intbl\li396\fi-396\cf1\f51\fs24\ql Administrative staff with responsibility for financial management and reporting on all activities\plain\intbl\li396\cf1\f51\fs24\ql conducted by the Contractor and any subcontractors.\cell{
{\trowd\cellx720\cellx10800\trrh864\row}}}\pard\plain\li1188\sa264\fi-792\cf1\f51\fs24\ql 2.1.7\plain\li1188\sa264\cf1\f51\fs20\ql \~\~\~\~
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs16\b\qr ***Confidential Treatment Requested
\par\pard\plain\fs16\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par
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\pard\plain\intbl\li396\cf1\f51\fs24\ql 2.1.8\cell\pard\plain\intbl\li396\fi-396\cf1\f51\fs24\ql Contract Review\plain\intbl\li396\cf1\f51\fs24\ql Meetings.\cell{
{\trowd\cellx540\cellx2688\trrh594\row}}}
\pard\plain
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\pard\plain\intbl\li792\cf1\f51\fs24\ql 2.1.8.1\cell\pard\plain\intbl\cf1\f51\fs24\ql The Contractor shall participate in regular meetings to coordinate and oversee the contract\plain\intbl\cf1\f51\fs24\ql effort as directed by the Contracting and Project Officers. Such meetings may include, but\plain\intbl\cf1\f51\fs24\ql are not limited to, meeting of the Contractors and subcontractors to discuss clinical\plain\intbl\cf1\f51\fs24\ql manufacturing progress, product development, product assay development, scale up\plain\intbl\cf1\f51\fs24\ql manufacturing development, clinical sample assays development, preclinical/clinical study\plain\intbl\cf1\f51\fs24\ql designs and regulatory issues; meetings with individual contractors and other HHS officials\plain\intbl\cf1\f51\fs24\ql to discuss the technical, regulatory, and ethical aspects of the program; and meeting with\plain\intbl\cf1\f51\fs24\ql technical consultants to discuss technical data provided by the Contractor.\cell{
{\trowd\cellx1710\cellx10800\trrh2376\row}}}
\pard\plain
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\pard\plain\intbl\li792\cf1\f51\fs24\ql 2.1.8.2\cell\pard\plain\intbl\cf1\f51\fs24\ql The Contractor shall participate in teleconferences every two weeks between the Contractor\plain\intbl\cf1\f51\fs24\ql and subcontractors and BARDA to review technical progress. Teleconferences or additional\plain\intbl\cf1\f51\fs24\ql face-to-face meetings shall be more frequent at the request of BARDA.\cell{
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\pard\plain\intbl\li396\cf1\f51\fs24\ql 2.1.9\cell\pard\plain\intbl\li396\fi-396\cf1\f51\fs24\ql Integrated Master\plain\intbl\li396\cf1\f51\fs24\ql Schedule\cell{
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\pard\plain\intbl\li792\cf1\f51\fs24\ql 2.1.9.1\cell\pard\plain\intbl\cf1\f51\fs24\ql Within 30 calendar days of the effective date of the contract, the Contractor shall submit a\plain\intbl\cf1\f51\fs24\ql first draft of an updated Integrated Master Schedule in a format agreed upon by BARDA to\plain\intbl\cf1\f51\fs24\ql the Project Officer and the Contracting Officer for review and comment. The Integrated\plain\intbl\cf1\f51\fs24\ql Master Schedule shall be incorporated into the contract, and will be used to monitor\plain\intbl\cf1\f51\fs24\ql performance of the contract. Contractor shall include the key milestones and Go/No Go\plain\intbl\cf1\f51\fs24\ql decision gates. The IMS for the period of performance will be mutually agreed upon at the\plain\intbl\cf1\f51\fs24\ql PMBR\cell{
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\pard\plain
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\pard\plain\intbl\li396\cf1\f51\fs24\ql 2.1.10\cell\pard\plain\intbl\li396\fi-396\cf1\f51\fs24\ql Integrated Master\plain\intbl\li396\cf1\f51\fs24\ql Plan\cell{
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\pard\plain
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\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx1710\clvertalc\cellx10800\trrh-66\row}}}
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\pard\plain\intbl\li792\cf1\f51\fs24\ql 2.1.10.1\cell\pard\plain\intbl\cf1\f51\fs24\ql Work Breakdown Structure: The Contractor shall utilize a WBS template agreed upon by\plain\intbl\cf1\f51\fs24\ql BARDA for reporting on the contact. The Contractor shall expand and delineate the\plain\intbl\cf1\f51\fs24\ql Contract Work Breakdown Structure (CWBS) to a level agreed upon by BARDA as part of\plain\intbl\cf1\f51\fs24\ql their Integrated Master Plan for contract reporting. The CWBS shall be discernable and\plain\intbl\cf1\f51\fs24\ql consistent. BARDA may require Contractor to furnish WBS data at the work package level\plain\intbl\cf1\f51\fs24\ql or at a lower level if there is significant complexity and risk associated with the task.\cell{
{\trowd\cellx1710\cellx10800\trrh1782\row}}}
\pard\plain
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{\trowd\clvertalc\cellx1710\clvertalc\cellx10800\trrh-66\row}}}
{\trowd\cellx1710\cellx10800\trrh1188
\pard\plain\intbl\li792\cf1\f51\fs24\ql 2.1.10.2\cell\pard\plain\intbl\cf1\f51\fs24\ql GO/NO-GO Decision Gates: The Integrated Master Plan outlines key milestones with\plain\intbl\cf1\f51\fs24\ql \u8220?Go/No Go\u8221? decision criteria (entrance and exit criteria for each phase of the\plain\intbl\cf1\f51\fs24\ql project). The project plan should include, but not be limited to, milestones in\plain\intbl\cf1\f51\fs24\ql manufacturing, non-clinical and clinical studies, and regulatory submissions.\cell{
{\trowd\cellx1710\cellx10800\trrh1188\row}}}
\pard\plain
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{\trowd\clvertalc\cellx1710\clvertalc\cellx10800\trrh-66\row}}}
{\trowd\cellx1710\cellx10800\trrh891
\pard\plain\intbl\li792\cf1\f51\fs24\ql 2.1.10.3\cell\pard\plain\intbl\cf1\f51\fs24\ql Earned Value Management System Plan: Subject to the requirements under HHSAR Clause\plain\intbl\cf1\f51\fs24\ql 352.234-4, the Contractor shall use principles of Earned Value Management System\plain\intbl\cf1\f51\fs24\ql (EVMS) in the management of this contract. The Seven Principles are:\cell{
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\pard\plain
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{\trowd\clvertalc\cellx1199\clvertalc\cellx5068\trrh-66\row}}}
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\pard\plain\intbl\li2376\cf1\f51\fs24\ql I.\cell\pard\plain\intbl\li22\fi-22\cf1\f51\fs24\ql Plan all work scope for the program to\plain\intbl\li22\cf1\f51\fs24\ql completion.\cell{
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\par\pard\plain\fs16\pard\plain\cf1\f51\fs24\qc 3
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{\trowd\clvertalc\cellx2580\clvertalc\cellx10800\trrh-66\row}}}
{\trowd\cellx2580\cellx10800\trrh891
\pard\plain\intbl\li2376\cf1\f51\fs24\ql II.\cell\pard\plain\intbl\li22\fi-22\cf1\f51\fs24\ql Break down the program work scope into finite pieces that can be assigned to a\plain\intbl\li22\cf1\f51\fs24\ql responsible person or organization for control of technical, schedule, and cost\plain\intbl\li22\cf1\f51\fs24\ql objectives.\cell{
{\trowd\cellx2580\cellx10800\trrh891\row}}}
\pard\plain
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\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx2580\clvertalc\cellx10800\trrh-66\row}}}
{\trowd\cellx2580\cellx10800\trrh891
\pard\plain\intbl\li2376\cf1\f51\fs24\ql III.\cell\pard\plain\intbl\li22\fi-22\cf1\f51\fs24\ql Integrate program work scope, schedule, and cost objectives into a performance\plain\intbl\li22\cf1\f51\fs24\ql measurement baseline plan against which accomplishments may be measured.\plain\intbl\li22\cf1\f51\fs24\ql Control Changes to the baseline.\cell{
{\trowd\cellx2580\cellx10800\trrh891\row}}}
\pard\plain
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\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx1914\clvertalc\cellx8143\trrh-66\row}}}
{\trowd\cellx1914\cellx8143\trrh594
\pard\plain\intbl\li2376\cf1\f51\fs24\ql IV.\cell\pard\plain\intbl\li22\fi-22\cf1\f51\fs24\ql Use actual cost incurred and recorded in accomplishing the\plain\intbl\li22\cf1\f51\fs24\ql work performed.\cell{
{\trowd\cellx1914\cellx8143\trrh594\row}}}
\pard\plain
{\trowd\clvertalc\cellx1595\clvertalc\cellx7084\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
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\pard\plain\intbl\li2376\cf1\f51\fs24\ql V.\cell\pard\plain\intbl\li22\fi-22\cf1\f51\fs24\ql Objectively assess accomplishments at the work\plain\intbl\li22\cf1\f51\fs24\ql performance level.\cell{
{\trowd\cellx1595\cellx7084\trrh594\row}}}
\pard\plain
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\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx2580\clvertalc\cellx10800\trrh-66\row}}}
{\trowd\cellx2580\cellx10800\trrh594
\pard\plain\intbl\li2376\cf1\f51\fs24\ql VI.\cell\pard\plain\intbl\li22\fi-22\cf1\f51\fs24\ql Analyze significant variances from the plan, forecast impacts, and prepare an\plain\intbl\li22\cf1\f51\fs24\ql estimate at completion based on performance to date and work to be performed.\cell{
{\trowd\cellx2580\cellx10800\trrh594\row}}}
\pard\plain
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\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx1963\clvertalc\cellx8370\trrh-66\row}}}
{\trowd\cellx1963\cellx8370\trrh594
\pard\plain\intbl\li2376\cf1\f51\fs24\ql VII.\cell\pard\plain\intbl\li22\fi-22\cf1\f51\fs24\ql Use earned value information in the company\u8217?s\plain\intbl\li22\cf1\f51\fs24\ql management processes.\cell{
{\trowd\cellx1963\cellx8370\trrh594\row}}}\pard\plain\li1584\cf1\f51\fs24\ql Elements of EVMS shall be applied to all Cost Plus Fixed Fee CLINs as part of the\plain\li1584\cf1\f51\fs24\ql Integrated Master Project Plan, the Contractor shall submit a written summary of the\plain\li1584\cf1\f51\fs24\ql management procedures that it will establish, maintain and use to comply with EVMS\plain\li1584\sa264\cf1\f51\fs24\ql requirements.
\par\pard\plain
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\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx720\clvertalc\cellx10800\trrh-66\row}}}
{\trowd\cellx720\cellx10800\trrh2349
\pard\plain\intbl\li396\cf1\f51\fs24\ql 2.1.11\cell\pard\plain\intbl\li396\fi-396\cf1\f51\fs24\ql Decision Gate Reporting: On completion of a stage of the product development, as defined in the\plain\intbl\li396\cf1\f51\fs24\ql agreed upon Integrated Master Schedule and Integrated Master Plan, the Contractor shall prepare\plain\intbl\li396\cf1\f51\fs24\ql and submit to the Project Officer and the Contracting Officer a Decision Gate Report that\plain\intbl\li396\cf1\f51\fs24\ql contains (i) sufficient detail, documentation and analysis to support successful completion of the\plain\intbl\li396\cf1\f51\fs24\ql stage according to the predetermined qualitative and quantitative criteria that were established for\plain\intbl\li396\cf1\f51\fs24\ql Go/No Go decision making; and (ii) a description of the next stage of product development to be\plain\intbl\li396\cf1\f51\fs24\ql initiated and a request for approval to proceed to the next stage of product development.\cell{
{\trowd\cellx720\cellx10800\trrh2349\row}}}
\pard\plain
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{\trowd\clvertalc\cellx720\clvertalc\cellx10800\trrh-66\row}}}
{\trowd\cellx720\cellx10800\trrh1755
\pard\plain\intbl\li396\cf1\f51\fs24\ql 2.1.12\cell\pard\plain\intbl\li396\fi-396\cf1\f51\fs24\ql Risk Management Plan: The Contractor shall develop a risk management plan within 90 days of\plain\intbl\li396\cf1\f51\fs24\ql contract award highlighting potential problems and/or issues that may arise during the life of the\plain\intbl\li396\cf1\f51\fs24\ql contract, their impact on cost, schedule and performance, and appropriate remediation plans. This\plain\intbl\li396\cf1\f51\fs24\ql plan should reference relevant WBS elements where appropriate. Updates to this plan shall be\plain\intbl\li396\cf1\f51\fs24\ql included every three months (quarterly) in the monthly Project Status Report.\cell{
{\trowd\cellx720\cellx10800\trrh1755\row}}}
\par\pard\plain\fs16\pard\plain\cf1\f51\fs24\qc 4
\par\pard\plain\fs16\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par
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\pard\plain\intbl\li396\cf1\f51\fs24\ql 2.1.13\cell\pard\plain\intbl\li396\fi-396\cf1\f51\fs24\ql Performance Measurement Baseline Review (PMBR): The Contractor shall submit a plan for a\plain\intbl\li396\cf1\f51\fs24\ql PMBR to occur within 90 days of contract award. At the PMBR, the Contractor and BARDA\plain\intbl\li396\cf1\f51\fs24\ql shall mutually agree upon the budget, schedule and technical plan baselines (Performance\plain\intbl\li396\cf1\f51\fs24\ql Measurement Baseline). These baselines shall be the basis for monitoring and reporting progress\plain\intbl\li396\cf1\f51\fs24\ql throughout the life of the contract. The PMBR is conducted to achieve confidence that the\plain\intbl\li396\cf1\f51\fs24\ql baselines accurately capture the entire technical scope of work, are consistent with contract\plain\intbl\li396\cf1\f51\fs24\ql schedule requirements, are reasonably and logically planned, and have adequate resources\plain\intbl\li396\cf1\f51\fs24\ql assigned. The goals of the PMBR are as\plain\intbl\li396\cf1\f51\fs24\b\ql FOLLOWS\plain\intbl\li396\cf1\f51\fs24\ql :\cell{
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{\trowd\clvertalc\cellx1800\clvertalc\cellx10800\trrh-66\row}}}
{\trowd\cellx1800\cellx10800\trrh891
\pard\plain\intbl\li1782\cf1\f51\fs24\ql I.\cell\pard\plain\intbl\cf1\f51\fs24\ql Jointly assess areas such as the Contractor\u8217?s planning for complete coverage of the\plain\intbl\cf1\f51\fs24\ql SOW, logical scheduling of the work activities, adequate resources, and identification of\plain\intbl\cf1\f51\fs24\ql inherent risks\cell{
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{\trowd\cellx1244\cellx7437\trrh594
\pard\plain\intbl\li1782\cf1\f51\fs24\ql II.\cell\pard\plain\intbl\cf1\f51\fs24\ql Confirm the integrity of the Performance Measurement\plain\intbl\cf1\f51\fs24\ql Baseline (PMB)\cell{
{\trowd\cellx1244\cellx7437\trrh594\row}}}
\pard\plain
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\pard\plain\intbl\li1782\cf1\f51\fs24\ql III.\cell\pard\plain\intbl\cf1\f51\fs24\ql Foster the use of EVM as a means of\plain\intbl\cf1\f51\fs24\ql communication\cell{
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\pard\plain
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\pard\plain\intbl\li1782\cf1\f51\fs24\ql IV.\cell\pard\plain\intbl\cf1\f51\fs24\ql Provide confidence in the validity of\plain\intbl\cf1\f51\fs24\ql Contractor reporting\cell{
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\pard\plain
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\pard\plain\intbl\li1782\cf1\f51\fs24\ql V.\cell\pard\plain\intbl\cf1\f51\fs24\ql Identify risks associated with\plain\intbl\cf1\f51\fs24\ql the PMB\cell{
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\pard\plain
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\pard\plain\intbl\li1782\cf1\f51\fs24\ql VI.\cell\pard\plain\intbl\cf1\f51\fs24\ql Present any revised PMBs for mutual\plain\intbl\cf1\f51\fs24\ql agreement\cell{
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{\trowd\clvertalc\cellx1800\clvertalc\cellx10800\trrh-66\row}}}
{\trowd\cellx1800\cellx10800\trrh1485
\pard\plain\intbl\li1782\cf1\f51\fs24\ql VII.\cell\pard\plain\intbl\li198\fi-198\cf1\f51\fs24\ql Present an Integrated Master Schedule: The Contractor shall deliver an initial program\plain\intbl\li198\cf1\f51\fs24\ql level Integrated Master Schedule (IMS) that rolls up all time-phased WBS elements\plain\intbl\li198\cf1\f51\fs24\ql down to the activity level. This IMS shall include the dependencies that exist between\plain\intbl\li198\cf1\f51\fs24\ql tasks. This IMS will be agreed to and finalized at the PMBR. DI-MGMT-81650 may\plain\intbl\li198\cf1\f51\fs24\ql be referenced as guidance in creation of the IMS (see http://www.acq.osd.mil/pm/).\cell{
{\trowd\cellx1800\cellx10800\trrh1485\row}}}
\pard\plain
{\trowd\clvertalc\cellx818\clvertalc\cellx3564\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx818\clvertalc\cellx3564\trrh-66\row}}}
{\trowd\cellx818\cellx3564\trrh594
\pard\plain\intbl\li1782\cf1\f51\fs24\ql VIII.\cell\pard\plain\intbl\cf1\f51\fs24\ql Present the Risk\plain\intbl\cf1\f51\fs24\ql Management Plan\cell{
{\trowd\cellx818\cellx3564\trrh594\row}}}
\pard\plain
{\trowd\clvertalc\cellx720\clvertalc\cellx10800\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx720\clvertalc\cellx10800\trrh-66\row}}}
{\trowd\cellx720\cellx10800\trrh2349
\pard\plain\intbl\li396\cf1\f51\fs24\ql 2.1.14\cell\pard\plain\intbl\li396\fi-396\cf1\f51\fs24\ql Deviation Request: During the course of contract performance, in response to a need to change IMS\plain\intbl\li396\cf1\f51\fs24\ql activities as baselined at the PMBR, the Contractor shall submit a Deviation Report. This report\plain\intbl\li396\cf1\f51\fs24\ql shall request a change in the agreed-upon IMS and timelines. This report shall include: (i)\plain\intbl\li396\cf1\f51\fs24\ql discussion of the justification/rationale for the proposed change; (ii) options for addressing the\plain\intbl\li396\cf1\f51\fs24\ql needed changes from the agreed upon timelines, including a cost-benefit analysis of each option;\plain\intbl\li396\cf1\f51\fs24\ql and (iii) recommendations for the preferred option that includes a full analysis and discussion of\plain\intbl\li396\cf1\f51\fs24\ql the effect of the change on the entire product development program, timelines, and budget.\cell{
{\trowd\cellx720\cellx10800\trrh2349\row}}}
\pard\plain
{\trowd\clvertalc\cellx720\clvertalc\cellx10800\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx720\clvertalc\cellx10800\trrh-66\row}}}
{\trowd\cellx720\cellx10800\trrh594
\pard\plain\intbl\li396\cf1\f51\fs24\ql 2.1.15\cell\pard\plain\intbl\li396\fi-396\cf1\f51\fs24\ql Monthly and Annual Reports: The Contractor shall deliver Project Status Reports on a monthly basis.\plain\intbl\li396\cf1\f51\fs24\ql The reports shall address the items below cross referenced to the WBS, SOW, IMS, and EVM:\cell{
{\trowd\cellx720\cellx10800\trrh594\row}}}
\pard\plain
{\trowd\clvertalc\cellx1800\clvertalc\cellx10800\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx1800\clvertalc\cellx10800\trrh-66\row}}}
{\trowd\cellx1800\cellx10800\trrh594
\pard\plain\intbl\li1782\cf1\f51\fs24\ql I.\cell\pard\plain\intbl\cf1\f51\fs24\ql Executive summary highlighting the progress, issues, and relevant activities in\plain\intbl\cf1\f51\fs24\ql manufacturing, non-clinical, clinical, and regulatory;\cell{
{\trowd\cellx1800\cellx10800\trrh594\row}}}
\par\pard\plain\fs16\pard\plain\cf1\f51\fs24\qc 5
\par\pard\plain\fs16\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par
\page
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\pard\plain
{\trowd\clvertalc\cellx1800\clvertalc\cellx10800\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx1800\clvertalc\cellx10800\trrh-66\row}}}
{\trowd\cellx1800\cellx10800\trrh891
\pard\plain\intbl\li1782\cf1\f51\fs24\ql II.\cell\pard\plain\intbl\li198\fi-198\cf1\f51\fs24\ql Progress in meeting contract milestones, detailing the planned progress and actual progress\plain\intbl\li198\cf1\f51\fs24\ql during the reporting period, explaining any differences between the two and corrective\plain\intbl\li198\cf1\f51\fs24\ql steps;\cell{
{\trowd\cellx1800\cellx10800\trrh891\row}}}
\par\pard\plain\fs16\pard\plain\cf1\f51\fs24\qc 6
\par\pard\plain\fs16\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par
\page{\*\bkmkstart s729829127866867B5005B43B98525CD}{\*\bkmkend s729829127866867B5005B43B98525CD}
\par\pard\plain\fs16
\par\pard\plain\fs16
\par\pard\plain\fs16
\pard\plain
{\trowd\clvertalc\cellx416\clvertalc\cellx1564\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx416\clvertalc\cellx1564\trrh-66\row}}}
{\trowd\cellx416\cellx1564\trrh594
\pard\plain\intbl\li1782\cf1\f51\fs24\ql III.\cell\pard\plain\intbl\cf1\f51\fs24\ql Updated\plain\intbl\cf1\f51\fs24\ql IMS;\cell{
{\trowd\cellx416\cellx1564\trrh594\row}}}
\pard\plain
{\trowd\clvertalc\cellx445\clvertalc\cellx1651\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx445\clvertalc\cellx1651\trrh-66\row}}}
{\trowd\cellx445\cellx1651\trrh594
\pard\plain\intbl\li1782\cf1\f51\fs24\ql IV.\cell\pard\plain\intbl\cf1\f51\fs24\ql Updated\plain\intbl\cf1\f51\fs24\ql EVM;\cell{
{\trowd\cellx445\cellx1651\trrh594\row}}}
\pard\plain
{\trowd\clvertalc\cellx903\clvertalc\cellx4957\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx903\clvertalc\cellx4957\trrh-66\row}}}
{\trowd\cellx903\cellx4957\trrh594
\pard\plain\intbl\li1782\cf1\f51\fs24\ql V.\cell\pard\plain\intbl\cf1\f51\fs24\ql Updated Risk Management Plan (Every\plain\intbl\cf1\f51\fs24\ql 3 months);\cell{
{\trowd\cellx903\cellx4957\trrh594\row}}}
\pard\plain
{\trowd\clvertalc\cellx969\clvertalc\cellx4838\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx969\clvertalc\cellx4838\trrh-66\row}}}
{\trowd\cellx969\cellx4838\trrh594
\pard\plain\intbl\li1782\cf1\f51\fs24\ql VI.\cell\pard\plain\intbl\cf1\f51\fs24\ql Three month rolling forecast of\plain\intbl\cf1\f51\fs24\ql planned activities;\cell{
{\trowd\cellx969\cellx4838\trrh594\row}}}
\pard\plain
{\trowd\clvertalc\cellx761\clvertalc\cellx3514\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx761\clvertalc\cellx3514\trrh-66\row}}}
{\trowd\cellx761\cellx3514\trrh594
\pard\plain\intbl\li1782\cf1\f51\fs24\ql VII.\cell\pard\plain\intbl\cf1\f51\fs24\ql Progress of regulatory\plain\intbl\cf1\f51\fs24\ql submissions;\cell{
{\trowd\cellx761\cellx3514\trrh594\row}}}
\pard\plain
{\trowd\clvertalc\cellx794\clvertalc\cellx3109\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx794\clvertalc\cellx3109\trrh-66\row}}}
{\trowd\cellx794\cellx3109\trrh594
\pard\plain\intbl\li1782\cf1\f51\fs24\ql VIII.\cell\pard\plain\intbl\cf1\f51\fs24\ql Estimated and actual\plain\intbl\cf1\f51\fs24\ql expenses;\cell{
{\trowd\cellx794\cellx3109\trrh594\row}}}
\pard\plain
{\trowd\clvertalc\cellx720\clvertalc\cellx10800\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx720\clvertalc\cellx10800\trrh-66\row}}}
{\trowd\cellx720\cellx10800\trrh891
\pard\plain\intbl\li396\cf1\f51\fs24\ql 2.1.16\cell\pard\plain\intbl\li396\fi-396\cf1\f51\fs24\ql Data Management: The Contractor shall develop and implement data management and quality control\plain\intbl\li396\cf1\f51\fs24\ql systems/procedures, including transmission, storage, confidentiality, and retrieval of all contract\plain\intbl\li396\cf1\f51\fs24\ql data;\cell{
{\trowd\cellx720\cellx10800\trrh891\row}}}
\pard\plain
{\trowd\clvertalc\cellx1537\clvertalc\cellx9097\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx1537\clvertalc\cellx9097\trrh-66\row}}}
{\trowd\cellx1537\cellx9097\trrh594
\pard\plain\intbl\li792\cf1\f51\fs24\ql 2.1.16.1\cell\pard\plain\intbl\cf1\f51\fs24\ql Provide for the statistical design and analysis of data resulting from the\plain\intbl\cf1\f51\fs24\ql research;\cell{
{\trowd\cellx1537\cellx9097\trrh594\row}}}
\pard\plain
{\trowd\clvertalc\cellx1710\clvertalc\cellx10800\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx1710\clvertalc\cellx10800\trrh-66\row}}}
{\trowd\cellx1710\cellx10800\trrh864
\pard\plain\intbl\li792\cf1\f51\fs24\ql 2.1.16.2\cell\pard\plain\intbl\cf1\f51\fs24\ql Provide raw data or specific analyses of data generated with contract funding to the Project\plain\intbl\cf1\f51\fs24\ql Officer, upon request.\cell{
{\trowd\cellx1710\cellx10800\trrh864\row}}}
\pard\plain
{\trowd\clvertalc\cellx375\clvertalc\cellx2542\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx375\clvertalc\cellx2542\trrh-66\row}}}
{\trowd\cellx375\cellx2542\trrh594
\pard\plain\intbl\cf1\f51\fs24\b\ql 2.2\cell\pard\plain\intbl\li88\fi-88\cf1\f51\fs24\b\qj Non-Clinical\plain\intbl\li88\cf1\f51\fs24\b\qj Toxicology\cell{
{\trowd\cellx375\cellx2542\trrh594\row}}}
\pard\plain
{\trowd\clvertalc\cellx520\clvertalc\cellx1757\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx520\clvertalc\cellx1757\trrh-66\row}}}
{\trowd\cellx520\cellx1757\trrh864
\pard\plain\intbl\li396\cf1\f51\fs24\ql 2.2.1\cell\pard\plain\intbl\li396\fi-396\cf1\f51\fs24\ql N/A (no\plain\intbl\li396\cf1\f51\fs24\ql scope)\cell{
{\trowd\cellx520\cellx1757\trrh864\row}}}
\pard\plain
{\trowd\clvertalc\cellx321\clvertalc\cellx1726\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx321\clvertalc\cellx1726\trrh-66\row}}}
{\trowd\cellx321\cellx1726\trrh297
\pard\plain\intbl\cf1\f51\fs24\b\ql 2.3\cell\pard\plain\intbl\li88\fi-88\cf1\f51\fs24\b\qj Non-Clinical\cell{
{\trowd\cellx321\cellx1726\trrh297\row}}}
\pard\plain
{\trowd\clvertalc\cellx643\clvertalc\cellx7884\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx643\clvertalc\cellx7884\trrh-66\row}}}
{\trowd\cellx643\cellx7884\trrh594
\pard\plain\intbl\li396\cf1\f51\fs24\ql 2.3.1\cell\pard\plain\intbl\li396\fi-396\cf1\f51\fs24\ql Develop and validate [\u8230?***\u8230?] to lower\plain\intbl\li396\cf1\f51\fs24\ql [\u8230?***\u8230?].\cell{
{\trowd\cellx643\cellx7884\trrh594\row}}}
\pard\plain
{\trowd\clvertalc\cellx720\clvertalc\cellx10800\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx720\clvertalc\cellx10800\trrh-66\row}}}
{\trowd\cellx720\cellx10800\trrh594
\pard\plain\intbl\li396\cf1\f51\fs24\ql 2.3.2\cell\pard\plain\intbl\li396\fi-396\cf1\f51\fs24\ql [\u8230?***\u8230?]: Conduct [\u8230?***\u8230?] studies including [\u8230?***\u8230?] studies,\plain\intbl\li396\cf1\f51\fs24\ql [\u8230?***\u8230?], and [\u8230?***\u8230?] studies in [\u8230?***\u8230?].\cell{
{\trowd\cellx720\cellx10800\trrh594\row}}}
\pard\plain
{\trowd\clvertalc\cellx501\clvertalc\cellx2611\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx501\clvertalc\cellx2611\trrh-66\row}}}
{\trowd\cellx501\cellx2611\trrh297
\pard\plain\intbl\li396\cf1\f51\fs24\ql 2.3.3\cell\pard\plain\intbl\li396\fi-396\cf1\f51\fs24\ql [\u8230?***\u8230?]\cell{
{\trowd\cellx501\cellx2611\trrh297\row}}}
\pard\plain
{\trowd\clvertalc\cellx1194\clvertalc\cellx6674\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx1194\clvertalc\cellx6674\trrh-66\row}}}
{\trowd\cellx1194\cellx6674\trrh594
\pard\plain\intbl\li792\cf1\f51\fs24\ql 2.3.3.1\cell\pard\plain\intbl\cf1\f51\fs24\ql Conduct [\u8230?***\u8230?] study in\plain\intbl\cf1\f51\fs24\ql [\u8230?***\u8230?].\cell{
{\trowd\cellx1194\cellx6674\trrh594\row}}}
\pard\plain
{\trowd\clvertalc\cellx1710\clvertalc\cellx10800\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx1710\clvertalc\cellx10800\trrh-66\row}}}
{\trowd\cellx1710\cellx10800\trrh891
\pard\plain\intbl\li792\cf1\f51\fs24\ql 2.3.3.2\cell\pard\plain\intbl\cf1\f51\fs24\ql Conduct [\u8230?***\u8230?] studies including [\u8230?***\u8230?] studies,\plain\intbl\cf1\f51\fs24\ql [\u8230?***\u8230?] studies including [\u8230?***\u8230?] for CMX-001 and\plain\intbl\cf1\f51\fs24\ql [\u8230?***\u8230?] in [\u8230?***\u8230?].\cell{
{\trowd\cellx1710\cellx10800\trrh891\row}}}
\pard\plain
{\trowd\clvertalc\cellx682\clvertalc\cellx9400\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx682\clvertalc\cellx9400\trrh-66\row}}}
{\trowd\cellx682\cellx9400\trrh297
\pard\plain\intbl\li396\cf1\f51\fs24\ql 2.3.4\cell\pard\plain\intbl\li396\fi-396\cf1\f51\fs24\ql Use of [\u8230?***\u8230?] as a CMX-001 Surrogate in [\u8230?***\u8230?] Studies.\cell{
{\trowd\cellx682\cellx9400\trrh297\row}}}
\pard\plain
{\trowd\clvertalc\cellx1710\clvertalc\cellx10800\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx1710\clvertalc\cellx10800\trrh-66\row}}}
{\trowd\cellx1710\cellx10800\trrh891
\pard\plain\intbl\li792\cf1\f51\fs24\ql 2.3.4.1\cell\pard\plain\intbl\cf1\f51\fs24\ql Dose [\u8230?***\u8230?] with [\u8230?***\u8230?] to identify the concentration of the\plain\intbl\cf1\f51\fs24\ql [\u8230?***\u8230?] in [\u8230?***\u8230?] associated with [\u8230?***\u8230?] of\plain\intbl\cf1\f51\fs24\ql [\u8230?***\u8230?].\cell{
{\trowd\cellx1710\cellx10800\trrh891\row}}}
\pard\plain
{\trowd\clvertalc\cellx720\clvertalc\cellx10800\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx720\clvertalc\cellx10800\trrh-66\row}}}
{\trowd\cellx720\cellx10800\trrh594
\pard\plain\intbl\li396\cf1\f51\fs24\ql 2.3.5\cell\pard\plain\intbl\li396\fi-396\cf1\f51\fs24\ql Scaling of [\u8230?***\u8230?] to [\u8230?***\u8230?] by conducting studies with\plain\intbl\li396\cf1\f51\fs24\ql [\u8230?***\u8230?] to determine [\u8230?***\u8230?] in [\u8230?***\u8230?].\cell{
{\trowd\cellx720\cellx10800\trrh594\row}}}
\pard\plain
{\trowd\clvertalc\cellx720\clvertalc\cellx10800\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx720\clvertalc\cellx10800\trrh-66\row}}}
{\trowd\cellx720\cellx10800\trrh594
\pard\plain\intbl\li396\cf1\f51\fs24\ql 2.3.6\cell\pard\plain\intbl\li396\fi-396\cf1\f51\fs24\ql [\u8230?***\u8230?] determination of CMX001, [\u8230?***\u8230?] and [\u8230?***\u8230?] in\plain\intbl\li396\cf1\f51\fs24\ql the [\u8230?***\u8230?].\cell{
{\trowd\cellx720\cellx10800\trrh594\row}}}
\pard\plain
{\trowd\clvertalc\cellx720\clvertalc\cellx10800\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx720\clvertalc\cellx10800\trrh-66\row}}}
{\trowd\cellx720\cellx10800\trrh594
\pard\plain\intbl\li396\cf1\f51\fs24\ql 2.3.7\cell\pard\plain\intbl\li396\fi-396\cf1\f51\fs24\ql Conduct [\u8230?***\u8230?] experiments to demonstrate [\u8230?***\u8230?] following effective\plain\intbl\li396\cf1\f51\fs24\ql [\u8230?***\u8230?] prior to [\u8230?***\u8230?].\cell{
{\trowd\cellx720\cellx10800\trrh594\row}}}
\pard\plain
{\trowd\clvertalc\cellx644\clvertalc\cellx7937\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx644\clvertalc\cellx7937\trrh-66\row}}}
{\trowd\cellx644\cellx7937\trrh594
\pard\plain\intbl\li396\cf1\f51\fs24\ql 2.3.8\cell\pard\plain\intbl\li396\fi-396\cf1\f51\fs24\ql Conduct studies to optimize [\u8230?***\u8230?] in\plain\intbl\li396\cf1\f51\fs24\ql [\u8230?***\u8230?].\cell{
{\trowd\cellx644\cellx7937\trrh594\row}}}
\pard\plain
{\trowd\clvertalc\cellx720\clvertalc\cellx10800\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx720\clvertalc\cellx10800\trrh-66\row}}}
{\trowd\cellx720\cellx10800\trrh864
\pard\plain\intbl\li396\cf1\f51\fs24\ql 2.3.9\cell\pard\plain\intbl\li396\fi-396\cf1\f51\fs24\ql Conduct CMX001 [\u8230?***\u8230?] study in [\u8230?***\u8230?] at a dose of CMX001\plain\intbl\li396\cf1\f51\fs24\ql equivalent or less than [\u8230?***\u8230?] with treatment beginning at the [\u8230?***\u8230?]\cell{
{\trowd\cellx720\cellx10800\trrh864\row}}}
\par\pard\plain\fs16\pard\plain\cf1\f51\fs24\qc 7\par\pard\plain\cf1\f51\fs16\b\qr ***Confidential Treatment Requested\par\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par
\page
\par\pard\plain\fs16
\par\pard\plain\fs16\par\pard\plain\li1188\fi-792\cf1\f51\fs24\ql 2.3.10\plain\li1188\sa264\cf1\f51\fs20\ql \~\~\~\~
\par\pard\plain
{\trowd\clvertalc\cellx321\clvertalc\cellx1162\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx321\clvertalc\cellx1162\trrh-66\row}}}
{\trowd\cellx321\cellx1162\trrh297
\pard\plain\intbl\cf1\f51\fs24\b\ql 2.4\cell\pard\plain\intbl\li88\fi-88\cf1\f51\fs24\b\qj Clinical\cell{
{\trowd\cellx321\cellx1162\trrh297\row}}}
\pard\plain
{\trowd\clvertalc\cellx720\clvertalc\cellx10800\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx720\clvertalc\cellx10800\trrh-66\row}}}
{\trowd\cellx720\cellx10800\trrh594
\pard\plain\intbl\li396\cf1\f51\fs24\ql 2.4.1\cell\pard\plain\intbl\li396\fi-396\cf1\f51\fs24\ql Measurement of [\u8230?***\u8230?] levels in [\u8230?***\u8230?] and correlate the\plain\intbl\li396\cf1\f51\fs24\ql [\u8230?***\u8230?] levels to studies conducted in [\u8230?***\u8230?].\cell{
{\trowd\cellx720\cellx10800\trrh594\row}}}
\pard\plain
{\trowd\clvertalc\cellx597\clvertalc\cellx5988\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx597\clvertalc\cellx5988\trrh-66\row}}}
{\trowd\cellx597\cellx5988\trrh594
\pard\plain\intbl\li396\cf1\f51\fs24\ql 2.4.2\cell\pard\plain\intbl\li396\fi-396\cf1\f51\fs24\ql Conduct expanded access protocol\plain\intbl\li396\cf1\f51\fs24\ql ([\u8230?***\u8230?]).\cell{
{\trowd\cellx597\cellx5988\trrh594\row}}}
\pard\plain
{\trowd\clvertalc\cellx720\clvertalc\cellx10800\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx720\clvertalc\cellx10800\trrh-66\row}}}
{\trowd\cellx720\cellx10800\trrh864
\pard\plain\intbl\li396\cf1\f51\fs24\ql 2.4.3\cell\pard\plain\intbl\li396\fi-396\cf1\f51\fs24\ql Analyze data and provide a Final Report for [\u8230?***\u8230?] evaluation of CMX001 in patients\plain\intbl\li396\cf1\f51\fs24\ql [\u8230?***\u8230?]\cell{
{\trowd\cellx720\cellx10800\trrh864\row}}}
\pard\plain
{\trowd\clvertalc\cellx321\clvertalc\cellx1509\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx321\clvertalc\cellx1509\trrh-66\row}}}
{\trowd\cellx321\cellx1509\trrh297
\pard\plain\intbl\cf1\f51\fs24\b\ql 2.5\cell\pard\plain\intbl\li88\fi-88\cf1\f51\fs24\b\qj Regulatory\cell{
{\trowd\cellx321\cellx1509\trrh297\row}}}
\pard\plain
{\trowd\clvertalc\cellx701\clvertalc\cellx10027\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx701\clvertalc\cellx10027\trrh-66\row}}}
{\trowd\cellx701\cellx10027\trrh297
\pard\plain\intbl\li396\cf1\f51\fs24\ql 2.5.1\cell\pard\plain\intbl\li396\fi-396\cf1\f51\fs24\ql Engaging the FDA on a path to support the treatment of smallpox indication with CMX-001\cell{
{\trowd\cellx701\cellx10027\trrh297\row}}}
\pard\plain
{\trowd\clvertalc\cellx720\clvertalc\cellx10800\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx720\clvertalc\cellx10800\trrh-66\row}}}
{\trowd\cellx720\cellx10800\trrh594
\pard\plain\intbl\li396\cf1\f51\fs24\ql 2.5.2\cell\pard\plain\intbl\li396\fi-396\cf1\f51\fs24\ql Preparing materials for and requesting, scheduling and participating in all meetings with the FDA,\plain\intbl\li396\cf1\f51\fs24\ql including meetings to review EUA and/or all other data packages;\cell{
{\trowd\cellx720\cellx10800\trrh594\row}}}
\pard\plain
{\trowd\clvertalc\cellx720\clvertalc\cellx10316\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx720\clvertalc\cellx10316\trrh-66\row}}}
{\trowd\cellx720\cellx10316\trrh594
\pard\plain\intbl\li396\cf1\f51\fs24\ql 2.5.3\cell\pard\plain\intbl\li396\fi-396\cf1\f51\fs24\ql Providing BARDA with (i) the initial draft minutes and final draft minutes of any formal\plain\intbl\li396\cf1\f51\fs24\ql meeting with the FDA; (ii) final minutes of any informal meeting with the FDA;\cell{
{\trowd\cellx720\cellx10316\trrh594\row}}}
\pard\plain
{\trowd\clvertalc\cellx720\clvertalc\cellx10800\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx720\clvertalc\cellx10800\trrh-66\row}}}
{\trowd\cellx720\cellx10800\trrh1188
\pard\plain\intbl\li396\cf1\f51\fs24\ql 2.5.4\cell\pard\plain\intbl\li396\fi-396\cf1\f51\fs24\ql Obtain FDA concurrence on the feasibility of the proposed [\u8230?***\u8230?] with\plain\intbl\li396\cf1\f51\fs24\ql CMX001/[\u8230?***\u8230?]/[\u8230?***\u8230?] in the [\u8230?***\u8230?], including FDA\plain\intbl\li396\cf1\f51\fs24\ql feedback on [\u8230?***\u8230?] and review of data for the first [\u8230?***\u8230?] enrolled\plain\intbl\li396\cf1\f51\fs24\ql in the [\u8230?***\u8230?] sub-study\cell{
{\trowd\cellx720\cellx10800\trrh1188\row}}}
\pard\plain
{\trowd\clvertalc\cellx720\clvertalc\cellx10800\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx720\clvertalc\cellx10800\trrh-66\row}}}
{\trowd\cellx720\cellx10800\trrh1161
\pard\plain\intbl\li396\cf1\f51\fs24\ql 2.5.5\cell\pard\plain\intbl\li396\fi-396\cf1\f51\fs24\ql Develop and submit a revised [\u8230?***\u8230?] for CMX001 for Treatment of Smallpox,\plain\intbl\li396\cf1\f51\fs24\ql including [\u8230?***\u8230?] for FDA review and comment, and revise the\plain\intbl\li396\cf1\f51\fs24\ql [\u8230?***\u8230?] as requested by FDA\cell{
{\trowd\cellx720\cellx10800\trrh1161\row}}}
\pard\plain
{\trowd\clvertalc\cellx321\clvertalc\cellx934\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx321\clvertalc\cellx934\trrh-66\row}}}
{\trowd\cellx321\cellx934\trrh297
\pard\plain\intbl\cf1\f51\fs24\b\ql 2.6\cell\pard\plain\intbl\li88\fi-88\cf1\f51\fs24\b\qj CMC\cell{
{\trowd\cellx321\cellx934\trrh297\row}}}
\pard\plain
{\trowd\clvertalc\cellx720\clvertalc\cellx10800\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx720\clvertalc\cellx10800\trrh-66\row}}}
{\trowd\cellx720\cellx10800\trrh594
\pard\plain\intbl\li396\cf1\f51\fs24\ql 2.6.1\cell\pard\plain\intbl\li396\fi-396\cf1\f51\fs24\ql Validation of the [\u8230?***\u8230?] process: Validation of the process to demonstrate the\plain\intbl\li396\cf1\f51\fs24\ql [\u8230?***\u8230?] of a [\u8230?***\u8230?] of acceptable quality will be performed.\cell{
{\trowd\cellx720\cellx10800\trrh594\row}}}
\pard\plain
{\trowd\clvertalc\cellx720\clvertalc\cellx10800\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx720\clvertalc\cellx10800\trrh-66\row}}}
{\trowd\cellx720\cellx10800\trrh1161
\pard\plain\intbl\li396\cf1\f51\fs24\ql 2.6.2\cell\pard\plain\intbl\li396\fi-396\cf1\f51\fs24\ql Validation of the [\u8230?***\u8230?] process to produce [\u8230?***\u8230?]: Validation of the\plain\intbl\li396\cf1\f51\fs24\ql process to demonstrate the [\u8230?***\u8230?] of a [\u8230?***\u8230?] of acceptable quality\plain\intbl\li396\cf1\f51\fs24\ql will be performed.\cell{
{\trowd\cellx720\cellx10800\trrh1161\row}}}
\pard\plain
{\trowd\clvertalc\cellx228\clvertalc\cellx3221\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx228\clvertalc\cellx3221\trrh-66\row}}}
{\trowd\cellx228\cellx3221\trrh864
\pard\plain\intbl\cf1\f51\fs24\b\ql 3.\cell\pard\plain\intbl\cf1\f51\fs24\b\ql PHASE II:\plain\intbl\cf1\f51\fs24\b\ql [\plain\intbl\cf1\f51\fs24\ql \u8230?***\u8230?\plain\intbl\cf1\f51\fs24\b\ql ]\cell{
{\trowd\cellx228\cellx3221\trrh864\row}}}\pard\plain\li396\sa264\cf1\f51\fs24\qj Research and development of CMX001 for the treatment of smallpox to include the following activities:\plain\li396\cf1\f51\fs24\qj [\u8230?***\u8230?]. The contractor shall carry out the following tasks and subtasks and in accordance\plain\li396\cf1\f51\fs24\qj with the agreed upon Integrated Master Schedule and Integrated Master Plan (defined in 2.1.8 and 2.1.9)\plain\li396\sa264\cf1\f51\fs24\qj which shall further detail the conduct of the specific tasks and subtasks.
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs24\qc 8\par\pard\plain\cf1\f51\fs16\b\qr ***Confidential Treatment Requested\par\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par
\page
\par\pard\plain\fs16
\par\pard\plain\fs16
\par\pard\plain\fs16
\pard\plain
{\trowd\clvertalc\cellx497\clvertalc\cellx5068\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx497\clvertalc\cellx5068\trrh-66\row}}}
{\trowd\cellx497\cellx5068\trrh594
\pard\plain\intbl\cf1\f51\fs24\b\ql 3.1\cell\pard\plain\intbl\li88\fi-88\cf1\f51\fs24\b\qj Program Management (consistent with\plain\intbl\li88\cf1\f51\fs24\b\qj section 2.1)\cell{
{\trowd\cellx497\cellx5068\trrh594\row}}}
\pard\plain
{\trowd\clvertalc\cellx720\clvertalc\cellx10800\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx720\clvertalc\cellx10800\trrh-66\row}}}
{\trowd\cellx720\cellx10800\trrh864
\pard\plain\intbl\li396\cf1\f51\fs24\ql 3.1.2\cell\pard\plain\intbl\li396\fi-396\cf1\f51\fs24\ql Program management scope in BASE year is consistent with program management scope in each\plain\intbl\li396\cf1\f51\fs24\ql option year.\cell{
{\trowd\cellx720\cellx10800\trrh864\row}}}
\pard\plain
{\trowd\clvertalc\cellx371\clvertalc\cellx2483\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx371\clvertalc\cellx2483\trrh-66\row}}}
{\trowd\cellx371\cellx2483\trrh594
\pard\plain\intbl\cf1\f51\fs24\b\ql 3.2\cell\pard\plain\intbl\li88\fi-88\cf1\f51\fs24\b\qj Non-Clinical\plain\intbl\li88\cf1\f51\fs24\b\qj toxicology\cell{
{\trowd\cellx371\cellx2483\trrh594\row}}}
\pard\plain
{\trowd\clvertalc\cellx629\clvertalc\cellx1872\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx629\clvertalc\cellx1872\trrh-66\row}}}
{\trowd\cellx629\cellx1872\trrh864
\pard\plain\intbl\li396\cf1\f51\fs24\ql 3.2.11\cell\pard\plain\intbl\li396\fi-396\cf1\f51\fs24\ql N/A (no\plain\intbl\li396\cf1\f51\fs24\ql scope)\cell{
{\trowd\cellx629\cellx1872\trrh864\row}}}
\pard\plain
{\trowd\clvertalc\cellx321\clvertalc\cellx1726\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx321\clvertalc\cellx1726\trrh-66\row}}}
{\trowd\cellx321\cellx1726\trrh297
\pard\plain\intbl\cf1\f51\fs24\b\ql 3.3\cell\pard\plain\intbl\li88\fi-88\cf1\f51\fs24\b\qj Non-Clinical\cell{
{\trowd\cellx321\cellx1726\trrh297\row}}}
\pard\plain
{\trowd\clvertalc\cellx707\clvertalc\cellx10325\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx707\clvertalc\cellx10325\trrh-66\row}}}
{\trowd\cellx707\cellx10325\trrh594
\pard\plain\intbl\li396\cf1\f51\fs24\ql 3.3.4\cell\pard\plain\intbl\li396\fi-396\cf1\f51\fs24\ql Quantify [\u8230?***\u8230?] concentrations in [\u8230?***\u8230?] from\plain\intbl\li396\cf1\f51\fs24\ql [\u8230?***\u8230?].\cell{
{\trowd\cellx707\cellx10325\trrh594\row}}}
\pard\plain
{\trowd\clvertalc\cellx700\clvertalc\cellx10091\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx700\clvertalc\cellx10091\trrh-66\row}}}
{\trowd\cellx700\cellx10091\trrh594
\pard\plain\intbl\li396\cf1\f51\fs24\ql 3.3.5\cell\pard\plain\intbl\li396\fi-396\cf1\f51\fs24\ql Determine [\u8230?***\u8230?] for CMX001 in [\u8230?***\u8230?] in\plain\intbl\li396\cf1\f51\fs24\ql [\u8230?***\u8230?].\cell{
{\trowd\cellx700\cellx10091\trrh594\row}}}
\pard\plain
{\trowd\clvertalc\cellx720\clvertalc\cellx10800\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx720\clvertalc\cellx10800\trrh-66\row}}}
{\trowd\cellx720\cellx10800\trrh1188
\pard\plain\intbl\li396\cf1\f51\fs24\ql 3.3.6\cell\pard\plain\intbl\li396\fi-396\cf1\f51\fs24\ql Scaling of [\u8230?***\u8230?] to [\u8230?***\u8230?] - Review with BARDA and FDA the\plain\intbl\li396\cf1\f51\fs24\ql [\u8230?***\u8230?] generated to support scaling between [\u8230?***\u8230?] and\plain\intbl\li396\cf1\f51\fs24\ql [\u8230?***\u8230?] using [\u8230?***\u8230?] as well as comparisons of [\u8230?***\u8230?]\plain\intbl\li396\cf1\f51\fs24\ql in the [\u8230?***\u8230?].\cell{
{\trowd\cellx720\cellx10800\trrh1188\row}}}
\pard\plain
{\trowd\clvertalc\cellx700\clvertalc\cellx10091\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx700\clvertalc\cellx10091\trrh-66\row}}}
{\trowd\cellx700\cellx10091\trrh594
\pard\plain\intbl\li396\cf1\f51\fs24\ql 3.3.7\cell\pard\plain\intbl\li396\fi-396\cf1\f51\fs24\ql Determine [\u8230?***\u8230?] for CMX001 in [\u8230?***\u8230?] in\plain\intbl\li396\cf1\f51\fs24\ql [\u8230?***\u8230?].\cell{
{\trowd\cellx700\cellx10091\trrh594\row}}}
\pard\plain
{\trowd\clvertalc\cellx523\clvertalc\cellx3340\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx523\clvertalc\cellx3340\trrh-66\row}}}
{\trowd\cellx523\cellx3340\trrh594
\pard\plain\intbl\li396\cf1\f51\fs24\ql 3.3.8\cell\pard\plain\intbl\li396\fi-396\cf1\f51\fs24\ql Conduct\plain\intbl\li396\cf1\f51\fs24\ql [\u8230?***\u8230?].\cell{
{\trowd\cellx523\cellx3340\trrh594\row}}}
\pard\plain
{\trowd\clvertalc\cellx594\clvertalc\cellx5663\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx594\clvertalc\cellx5663\trrh-66\row}}}
{\trowd\cellx594\cellx5663\trrh594
\pard\plain\intbl\li396\cf1\f51\fs24\ql 3.3.9\cell\pard\plain\intbl\li396\fi-396\cf1\f51\fs24\ql Conduct [\u8230?***\u8230?] and\plain\intbl\li396\cf1\f51\fs24\ql [\u8230?***\u8230?]\cell{
{\trowd\cellx594\cellx5663\trrh594\row}}}
\pard\plain
{\trowd\clvertalc\cellx720\clvertalc\cellx10800\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx720\clvertalc\cellx10800\trrh-66\row}}}
{\trowd\cellx720\cellx10800\trrh864
\pard\plain\intbl\li396\cf1\f51\fs24\ql 3.3.10\cell\pard\plain\intbl\li396\fi-396\cf1\f51\fs24\ql Chimerix will provide [\u8230?***\u8230?] for the [\u8230?***\u8230?] and [\u8230?***\u8230?]\plain\intbl\li396\cf1\f51\fs24\ql conducted under [\u8230?***\u8230?]\cell{
{\trowd\cellx720\cellx10800\trrh864\row}}}
\pard\plain
{\trowd\clvertalc\cellx321\clvertalc\cellx1162\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx321\clvertalc\cellx1162\trrh-66\row}}}
{\trowd\cellx321\cellx1162\trrh297
\pard\plain\intbl\cf1\f51\fs24\b\ql 3.4\cell\pard\plain\intbl\li88\fi-88\cf1\f51\fs24\b\qj Clinical\cell{
{\trowd\cellx321\cellx1162\trrh297\row}}}
\pard\plain
{\trowd\clvertalc\cellx521\clvertalc\cellx1791\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx521\clvertalc\cellx1791\trrh-66\row}}}
{\trowd\cellx521\cellx1791\trrh864
\pard\plain\intbl\li396\cf1\f51\fs24\ql 3.4.6\cell\pard\plain\intbl\li396\fi-396\cf1\f51\fs24\ql N/A (No\plain\intbl\li396\cf1\f51\fs24\ql scope)\cell{
{\trowd\cellx521\cellx1791\trrh864\row}}}
\par\pard\plain\fs16\pard\plain\cf1\f51\fs24\qc 9\par\pard\plain\cf1\f51\fs16\b\qr ***Confidential Treatment Requested\par\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par
\page
\par\pard\plain\fs16
\par\pard\plain\fs16
\par\pard\plain\fs16
\pard\plain
{\trowd\clvertalc\cellx321\clvertalc\cellx1509\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx321\clvertalc\cellx1509\trrh-66\row}}}
{\trowd\cellx321\cellx1509\trrh297
\pard\plain\intbl\cf1\f51\fs24\b\ql 3.5\cell\pard\plain\intbl\li88\fi-88\cf1\f51\fs24\b\qj Regulatory\cell{
{\trowd\cellx321\cellx1509\trrh297\row}}}
\pard\plain
{\trowd\clvertalc\cellx698\clvertalc\cellx9892\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx698\clvertalc\cellx9892\trrh-66\row}}}
{\trowd\cellx698\cellx9892\trrh297
\pard\plain\intbl\li396\cf1\f51\fs24\ql 3.5.3\cell\pard\plain\intbl\li396\fi-396\cf1\f51\fs24\ql Engaging the FDA on a path to support the treatment of smallpox indication with CMX001\cell{
{\trowd\cellx698\cellx9892\trrh297\row}}}
\pard\plain
{\trowd\clvertalc\cellx679\clvertalc\cellx9298\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx679\clvertalc\cellx9298\trrh-66\row}}}
{\trowd\cellx679\cellx9298\trrh594
\pard\plain\intbl\li396\cf1\f51\fs24\ql 3.5.4\cell\pard\plain\intbl\li396\fi-396\cf1\f51\fs24\ql Generating all necessary documentation for [\u8230?***\u8230?].\plain\intbl\li396\cf1\f51\fs24\ql [\u8230?***\u8230?]\cell{
{\trowd\cellx679\cellx9298\trrh594\row}}}
\pard\plain
{\trowd\clvertalc\cellx720\clvertalc\cellx10800\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx720\clvertalc\cellx10800\trrh-66\row}}}
{\trowd\cellx720\cellx10800\trrh594
\pard\plain\intbl\li396\cf1\f51\fs24\ql 3.5.5\cell\pard\plain\intbl\li396\fi-396\cf1\f51\fs24\ql Preparing materials for and requesting, scheduling and participating in all meetings with the FDA,\plain\intbl\li396\cf1\f51\fs24\ql including meetings to review EUA (if needed) and/or all other data packages;\cell{
{\trowd\cellx720\cellx10800\trrh594\row}}}
\pard\plain
{\trowd\clvertalc\cellx720\clvertalc\cellx10800\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx720\clvertalc\cellx10800\trrh-66\row}}}
{\trowd\cellx720\cellx10800\trrh1161
\pard\plain\intbl\li396\cf1\f51\fs24\ql 3.5.6\cell\pard\plain\intbl\li396\fi-396\cf1\f51\fs24\ql Providing BARDA with (i) the initial draft minutes and final draft minutes of any formal meeting\plain\intbl\li396\cf1\f51\fs24\ql with the FDA relating to the smallpox program; (ii) final draft minutes of any informal meeting\plain\intbl\li396\cf1\f51\fs24\ql with the FDA relating to the smallpox program.\cell{
{\trowd\cellx720\cellx10800\trrh1161\row}}}
\pard\plain
{\trowd\clvertalc\cellx321\clvertalc\cellx934\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx321\clvertalc\cellx934\trrh-66\row}}}
{\trowd\cellx321\cellx934\trrh297
\pard\plain\intbl\cf1\f51\fs24\b\ql 3.6\cell\pard\plain\intbl\li88\fi-88\cf1\f51\fs24\b\qj CMC\cell{
{\trowd\cellx321\cellx934\trrh297\row}}}
\pard\plain
{\trowd\clvertalc\cellx521\clvertalc\cellx1791\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx521\clvertalc\cellx1791\trrh-66\row}}}
{\trowd\cellx521\cellx1791\trrh864
\pard\plain\intbl\li396\cf1\f51\fs24\ql 3.6.1\cell\pard\plain\intbl\li396\fi-396\cf1\f51\fs24\ql N/A (No\plain\intbl\li396\cf1\f51\fs24\ql scope)\cell{
{\trowd\cellx521\cellx1791\trrh864\row}}}
\pard\plain
{\trowd\clvertalc\cellx230\clvertalc\cellx3296\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx230\clvertalc\cellx3296\trrh-66\row}}}
{\trowd\cellx230\cellx3296\trrh864
\pard\plain\intbl\cf1\f51\fs24\b\ql 4.\cell\pard\plain\intbl\cf1\f51\fs24\b\qj PHASE III:\plain\intbl\cf1\f51\fs24\b\qj [\plain\intbl\cf1\f51\fs24\qj \u8230?***\u8230?\plain\intbl\cf1\f51\fs24\b\qj ]\cell{
{\trowd\cellx230\cellx3296\trrh864\row}}}\pard\plain\sa264\cf1\f51\fs24\ql Research and development of CMX001 for the treatment of smallpox and dsDNA viruses to include the\plain\cf1\f51\fs24\ql following activities: [\u8230?***\u8230?] Study, [\u8230?***\u8230?] Study, [\u8230?***\u8230?]. The\plain\cf1\f51\fs24\ql contractor shall carry out the following tasks and subtasks and in accordance with agreed upon Integrated\plain\cf1\f51\fs24\ql Master Schedule and Integrated Master Plan (defined in 2.1.8 and 2.1.9) which shall further detail the\plain\sa264\cf1\f51\fs24\ql conduct of the specific tasks and subtasks.
\par\pard\plain
{\trowd\clvertalc\cellx495\clvertalc\cellx5014\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx495\clvertalc\cellx5014\trrh-66\row}}}
{\trowd\cellx495\cellx5014\trrh594
\pard\plain\intbl\cf1\f51\fs24\b\ql 4.1\cell\pard\plain\intbl\li88\fi-88\cf1\f51\fs24\b\qj Program Management\plain\intbl\li88\cf1\f51\fs24\qj (Consistent with\plain\intbl\li88\cf1\f51\fs24\qj section 2.1)\cell{
{\trowd\cellx495\cellx5014\trrh594\row}}}
\pard\plain
{\trowd\clvertalc\cellx720\clvertalc\cellx10800\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx720\clvertalc\cellx10800\trrh-66\row}}}
{\trowd\cellx720\cellx10800\trrh864
\pard\plain\intbl\li396\cf1\f51\fs24\ql 4.1.12\cell\pard\plain\intbl\li396\fi-396\cf1\f51\fs24\ql Program management scope in BASE year is consistent with program management scope in each\plain\intbl\li396\cf1\f51\fs24\ql option year.\cell{
{\trowd\cellx720\cellx10800\trrh864\row}}}
\pard\plain
{\trowd\clvertalc\cellx371\clvertalc\cellx2483\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx371\clvertalc\cellx2483\trrh-66\row}}}
{\trowd\cellx371\cellx2483\trrh594
\pard\plain\intbl\cf1\f51\fs24\b\ql 4.2\cell\pard\plain\intbl\li88\fi-88\cf1\f51\fs24\b\qj Non-Clinical\plain\intbl\li88\cf1\f51\fs24\b\qj toxicology\cell{
{\trowd\cellx371\cellx2483\trrh594\row}}}
\pard\plain
{\trowd\clvertalc\cellx629\clvertalc\cellx1872\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx629\clvertalc\cellx1872\trrh-66\row}}}
{\trowd\cellx629\cellx1872\trrh864
\pard\plain\intbl\li396\cf1\f51\fs24\ql 4.2.11\cell\pard\plain\intbl\li396\fi-396\cf1\f51\fs24\ql N/A (no\plain\intbl\li396\cf1\f51\fs24\ql scope)\cell{
{\trowd\cellx629\cellx1872\trrh864\row}}}
\par\pard\plain\fs16\pard\plain\cf1\f51\fs24\qc 10\par\pard\plain\cf1\f51\fs16\b\qr ***Confidential Treatment Requested\par\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par
\page
\par\pard\plain\fs16
\par\pard\plain\fs16
\par\pard\plain\fs16
\pard\plain
{\trowd\clvertalc\cellx321\clvertalc\cellx1726\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx321\clvertalc\cellx1726\trrh-66\row}}}
{\trowd\cellx321\cellx1726\trrh297
\pard\plain\intbl\cf1\f51\fs24\b\ql 4.3\cell\pard\plain\intbl\li88\fi-88\cf1\f51\fs24\b\qj Non-Clinical\cell{
{\trowd\cellx321\cellx1726\trrh297\row}}}
\pard\plain
{\trowd\clvertalc\cellx720\clvertalc\cellx10800\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx720\clvertalc\cellx10800\trrh-66\row}}}
{\trowd\cellx720\cellx10800\trrh2673
\pard\plain\intbl\li396\cf1\f51\fs24\ql 4.3.7\cell\pard\plain\intbl\li396\fi-396\cf1\f51\fs24\ql [\u8230?***\u8230?] studies: A [\u8230?***\u8230?] study will be conducted with the\plain\intbl\li396\cf1\f51\fs24\ql [\u8230?***\u8230?] of CMX001 selected based on the results of the [\u8230?***\u8230?] and\plain\intbl\li396\cf1\f51\fs24\ql [\u8230?***\u8230?] studies. [\u8230?***\u8230?] will be [\u8230?***\u8230?] to receive\plain\intbl\li396\cf1\f51\fs24\ql [\u8230?***\u8230?] beginning at the [\u8230?***\u8230?] or the FDA agreed upon trigger for\plain\intbl\li396\cf1\f51\fs24\ql treatment. The first [\u8230?***\u8230?] study will be a [\u8230?***\u8230?] study of CMX001\plain\intbl\li396\cf1\f51\fs24\ql in the [\u8230?***\u8230?] model. A study will be conducted with an [\u8230?***\u8230?] of\plain\intbl\li396\cf1\f51\fs24\ql CMX001 to determine the [\u8230?***\u8230?] after observation of the FDA agreed upon trigger\plain\intbl\li396\cf1\f51\fs24\ql for treatment. These studies will include [\u8230?***\u8230?] and [\u8230?***\u8230?]. The\plain\intbl\li396\cf1\f51\fs24\ql primary endpoint will be [\u8230?***\u8230?].\cell{
{\trowd\cellx720\cellx10800\trrh2673\row}}}
\pard\plain
{\trowd\clvertalc\cellx720\clvertalc\cellx10800\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx720\clvertalc\cellx10800\trrh-66\row}}}
{\trowd\cellx720\cellx10800\trrh2673
\pard\plain\intbl\li396\cf1\f51\fs24\ql 4.3.8\cell\pard\plain\intbl\li396\fi-396\cf1\f51\fs24\ql A [\u8230?***\u8230?] study of CMX001 in the [\u8230?***\u8230?]: The delayed treatment study\plain\intbl\li396\cf1\f51\fs24\ql will evaluate the [\u8230?***\u8230?] of CMX001 at [\u8230?***\u8230?]. The study will\plain\intbl\li396\cf1\f51\fs24\ql include [\u8230?***\u8230?] and [\u8230?***\u8230?] agreed upon with the FDA. The primary\plain\intbl\li396\cf1\f51\fs24\ql endpoint will be [\u8230?***\u8230?]. A [\u8230?***\u8230?] study to measure\plain\intbl\li396\cf1\f51\fs24\ql [\u8230?***\u8230?] in the selected [\u8230?***\u8230?] will be conducted to confirm the\plain\intbl\li396\cf1\f51\fs24\ql [\u8230?***\u8230?]. A [\u8230?***\u8230?] study will be conducted prior to\plain\intbl\li396\cf1\f51\fs24\ql [\u8230?***\u8230?] studies in the [\u8230?***\u8230?] to 1) determine [\u8230?***\u8230?]\plain\intbl\li396\cf1\f51\fs24\ql and [\u8230?***\u8230?] of [\u8230?***\u8230?] and 2) to confirm presence of\plain\intbl\li396\cf1\f51\fs24\ql [\u8230?***\u8230?] at fixed intervals [\u8230?***\u8230?].\cell{
{\trowd\cellx720\cellx10800\trrh2673\row}}}
\pard\plain
{\trowd\clvertalc\cellx720\clvertalc\cellx10800\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx720\clvertalc\cellx10800\trrh-66\row}}}
{\trowd\cellx720\cellx10800\trrh594
\pard\plain\intbl\li396\cf1\f51\fs24\ql 4.3.9\cell\pard\plain\intbl\li396\fi-396\cf1\f51\fs24\ql Conduct additional studies in [\u8230?***\u8230?] to determine [\u8230?***\u8230?] and\plain\intbl\li396\cf1\f51\fs24\ql [\u8230?***\u8230?] for CMX001 at [\u8230?***\u8230?].\cell{
{\trowd\cellx720\cellx10800\trrh594\row}}}
\pard\plain
{\trowd\clvertalc\cellx661\clvertalc\cellx5700\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx661\clvertalc\cellx5700\trrh-66\row}}}
{\trowd\cellx661\cellx5700\trrh594
\pard\plain\intbl\li396\cf1\f51\fs24\ql 4.3.10\cell\pard\plain\intbl\li396\fi-396\cf1\f51\fs24\ql Conduct [\u8230?***\u8230?] of\plain\intbl\li396\cf1\f51\fs24\ql [\u8230?***\u8230?].\cell{
{\trowd\cellx661\cellx5700\trrh594\row}}}
\pard\plain
{\trowd\clvertalc\cellx720\clvertalc\cellx10800\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx720\clvertalc\cellx10800\trrh-66\row}}}
{\trowd\cellx720\cellx10800\trrh864
\pard\plain\intbl\li396\cf1\f51\fs24\ql 4.3.11\cell\pard\plain\intbl\li396\fi-396\cf1\f51\fs24\ql Conduct additional studies for [\u8230?***\u8230?] of [\u8230?***\u8230?] to be used in\plain\intbl\li396\cf1\f51\fs24\ql [\u8230?***\u8230?].\cell{
{\trowd\cellx720\cellx10800\trrh864\row}}}
\pard\plain
{\trowd\clvertalc\cellx321\clvertalc\cellx1162\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx321\clvertalc\cellx1162\trrh-66\row}}}
{\trowd\cellx321\cellx1162\trrh297
\pard\plain\intbl\cf1\f51\fs24\b\ql 4.4\cell\pard\plain\intbl\li88\fi-88\cf1\f51\fs24\b\qj Clinical\cell{
{\trowd\cellx321\cellx1162\trrh297\row}}}
\pard\plain
{\trowd\clvertalc\cellx720\clvertalc\cellx10800\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx720\clvertalc\cellx10800\trrh-66\row}}}
{\trowd\cellx720\cellx10800\trrh1458
\pard\plain\intbl\li396\cf1\f51\fs24\ql 4.4.7\cell\pard\plain\intbl\li396\fi-396\cf1\f51\fs24\ql Clinical [\u8230?***\u8230?] studies to evaluate [\u8230?***\u8230?] used in previous clinical\plain\intbl\li396\cf1\f51\fs24\ql studies and [\u8230?***\u8230?] used in previous clinical studies and [\u8230?***\u8230?]. This\plain\intbl\li396\cf1\f51\fs24\ql study will [\u8230?***\u8230?] to [\u8230?***\u8230?] to determine if [\u8230?***\u8230?] are\plain\intbl\li396\cf1\f51\fs24\ql comparable.\cell{
{\trowd\cellx720\cellx10800\trrh1458\row}}}
\par\pard\plain\fs16\pard\plain\cf1\f51\fs24\qc 11\par\pard\plain\cf1\f51\fs16\b\qr ***Confidential Treatment Requested\par\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par
\page
\par\pard\plain\fs16
\par\pard\plain\fs16
\par\pard\plain\fs16
\pard\plain
{\trowd\clvertalc\cellx321\clvertalc\cellx1509\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx321\clvertalc\cellx1509\trrh-66\row}}}
{\trowd\cellx321\cellx1509\trrh297
\pard\plain\intbl\cf1\f51\fs24\b\ql 4.5\cell\pard\plain\intbl\li88\fi-88\cf1\f51\fs24\b\qj Regulatory\cell{
{\trowd\cellx321\cellx1509\trrh297\row}}}
\pard\plain
{\trowd\clvertalc\cellx720\clvertalc\cellx10800\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx720\clvertalc\cellx10800\trrh-66\row}}}
{\trowd\cellx720\cellx10800\trrh594
\pard\plain\intbl\li396\cf1\f51\fs24\ql 4.5.2\cell\pard\plain\intbl\li396\fi-396\cf1\f51\fs24\ql Generating all necessary data and preparing documentation for an [\u8230?***\u8230?] meeting\plain\intbl\li396\cf1\f51\fs24\ql submissions to regulatory agencies;\cell{
{\trowd\cellx720\cellx10800\trrh594\row}}}
\pard\plain
{\trowd\clvertalc\cellx720\clvertalc\cellx10800\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx720\clvertalc\cellx10800\trrh-66\row}}}
{\trowd\cellx720\cellx10800\trrh891
\pard\plain\intbl\li396\cf1\f51\fs24\ql 4.5.3\cell\pard\plain\intbl\li396\fi-396\cf1\f51\fs24\ql Preparing materials for and requesting, scheduling and participating in all meetings with the FDA,\plain\intbl\li396\cf1\f51\fs24\ql including the [\u8230?***\u8230?] Meeting, meetings to review [\u8230?***\u8230?], EUA (if\plain\intbl\li396\cf1\f51\fs24\ql needed) and/or all other data packages;\cell{
{\trowd\cellx720\cellx10800\trrh891\row}}}
\pard\plain
{\trowd\clvertalc\cellx720\clvertalc\cellx10800\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx720\clvertalc\cellx10800\trrh-66\row}}}
{\trowd\cellx720\cellx10800\trrh891
\pard\plain\intbl\li396\cf1\f51\fs24\ql 4.5.4\cell\pard\plain\intbl\li396\fi-396\cf1\f51\fs24\ql Providing BARDA with (i) the initial draft minutes and final draft minutes of any formal meeting\plain\intbl\li396\cf1\f51\fs24\ql with the FDA relating to this Contract; (ii) final draft minutes of any informal meeting with the\plain\intbl\li396\cf1\f51\fs24\ql FDA;\cell{
{\trowd\cellx720\cellx10800\trrh891\row}}}
\pard\plain
{\trowd\clvertalc\cellx627\clvertalc\cellx7109\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx627\clvertalc\cellx7109\trrh-66\row}}}
{\trowd\cellx627\cellx7109\trrh864
\pard\plain\intbl\li396\cf1\f51\fs24\ql 4.5.5\cell\pard\plain\intbl\li396\fi-396\cf1\f51\fs24\ql Preparing an [\u8230?***\u8230?] submission\plain\intbl\li396\cf1\f51\fs24\ql [\u8230?***\u8230?].\cell{
{\trowd\cellx627\cellx7109\trrh864\row}}}
\par\pard\plain\fs16
\pard\plain
{\trowd\clvertalc\cellx321\clvertalc\cellx934\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx321\clvertalc\cellx934\trrh-66\row}}}
{\trowd\cellx321\cellx934\trrh297
\pard\plain\intbl\cf1\f51\fs24\b\ql 4.6\cell\pard\plain\intbl\li88\fi-88\cf1\f51\fs24\b\qj CMC\cell{
{\trowd\cellx321\cellx934\trrh297\row}}}
\pard\plain
{\trowd\clvertalc\cellx720\clvertalc\cellx10800\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx720\clvertalc\cellx10800\trrh-66\row}}}
{\trowd\cellx720\cellx10800\trrh864
\pard\plain\intbl\li396\cf1\f51\fs24\ql 4.6.1\cell\pard\plain\intbl\li396\fi-396\cf1\f51\fs24\ql [\u8230?***\u8230?] in order to generate [\u8230?***\u8230?] for registration and clinical trial\plain\intbl\li396\cf1\f51\fs24\ql supplies.\cell{
{\trowd\cellx720\cellx10800\trrh864\row}}}
\pard\plain
{\trowd\clvertalc\cellx720\clvertalc\cellx10800\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx720\clvertalc\cellx10800\trrh-66\row}}}
{\trowd\cellx720\cellx10800\trrh864
\pard\plain\intbl\li396\cf1\f51\fs24\ql 4.6.2\cell\pard\plain\intbl\li396\fi-396\cf1\f51\fs24\ql [\u8230?***\u8230?]. Validation of the process to demonstrate the [\u8230?***\u8230?] of a\plain\intbl\li396\cf1\f51\fs24\ql [\u8230?***\u8230?] of acceptable quality will be performed.\cell{
{\trowd\cellx720\cellx10800\trrh864\row}}}
\pard\plain
{\trowd\clvertalc\cellx230\clvertalc\cellx3286\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx230\clvertalc\cellx3286\trrh-66\row}}}
{\trowd\cellx230\cellx3286\trrh864
\pard\plain\intbl\cf1\f51\fs24\b\ql 5.\cell\pard\plain\intbl\cf1\f51\fs24\b\qj PHASE IV:\plain\intbl\cf1\f51\fs24\b\qj [\plain\intbl\cf1\f51\fs24\qj \u8230?***\u8230?\plain\intbl\cf1\f51\fs24\b\qj ]\cell{
{\trowd\cellx230\cellx3286\trrh864\row}}}\pard\plain\li396\sa264\cf1\f51\fs24\qj Research and development of CMX-001 for the treatment of smallpox to include the following\plain\li396\cf1\f51\fs24\qj activities: [\u8230?***\u8230?], [\u8230?***\u8230?], [\u8230?***\u8230?], [\u8230?***\u8230?] and\plain\li396\cf1\f51\fs24\qj [\u8230?***\u8230?]. The contractor shall carry out the following tasks and subtasks and in accordance\plain\li396\cf1\f51\fs24\qj with agreed upon Integrated Master Schedule and Integrated Master Plan (defined in 2.1.8 and 2.1.9)\plain\li396\sa264\cf1\f51\fs24\qj which shall further detail the conduct of the specific tasks and subtasks.
\par\pard\plain
{\trowd\clvertalc\cellx495\clvertalc\cellx5014\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx495\clvertalc\cellx5014\trrh-66\row}}}
{\trowd\cellx495\cellx5014\trrh594
\pard\plain\intbl\cf1\f51\fs24\b\ql 5.1\cell\pard\plain\intbl\li88\fi-88\cf1\f51\fs24\b\qj Program Management\plain\intbl\li88\cf1\f51\fs24\qj (Consistent with\plain\intbl\li88\cf1\f51\fs24\qj section 2.1)\cell{
{\trowd\cellx495\cellx5014\trrh594\row}}}
\pard\plain
{\trowd\clvertalc\cellx720\clvertalc\cellx10800\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx720\clvertalc\cellx10800\trrh-66\row}}}
{\trowd\cellx720\cellx10800\trrh864
\pard\plain\intbl\li396\cf1\f51\fs24\ql 5.1.12\cell\pard\plain\intbl\li396\fi-396\cf1\f51\fs24\ql Program management scope in BASE year is consistent with program management scope in each\plain\intbl\li396\cf1\f51\fs24\ql option year.\cell{
{\trowd\cellx720\cellx10800\trrh864\row}}}
\pard\plain
{\trowd\clvertalc\cellx371\clvertalc\cellx2483\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx371\clvertalc\cellx2483\trrh-66\row}}}
{\trowd\cellx371\cellx2483\trrh594
\pard\plain\intbl\cf1\f51\fs24\b\ql 5.2\cell\pard\plain\intbl\li88\fi-88\cf1\f51\fs24\b\qj Non-Clinical\plain\intbl\li88\cf1\f51\fs24\b\qj toxicology\cell{
{\trowd\cellx371\cellx2483\trrh594\row}}}
\pard\plain
{\trowd\clvertalc\cellx629\clvertalc\cellx1872\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx629\clvertalc\cellx1872\trrh-66\row}}}
{\trowd\cellx629\cellx1872\trrh864
\pard\plain\intbl\li396\cf1\f51\fs24\ql 5.2.12\cell\pard\plain\intbl\li396\fi-396\cf1\f51\fs24\ql N/A (no\plain\intbl\li396\cf1\f51\fs24\ql scope)\cell{
{\trowd\cellx629\cellx1872\trrh864\row}}}
\pard\plain
{\trowd\clvertalc\cellx321\clvertalc\cellx1726\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx321\clvertalc\cellx1726\trrh-66\row}}}
{\trowd\cellx321\cellx1726\trrh567
\pard\plain\intbl\cf1\f51\fs24\b\ql 5.3\cell\pard\plain\intbl\li88\fi-88\cf1\f51\fs24\b\qj Non-Clinical\cell{
{\trowd\cellx321\cellx1726\trrh567\row}}}
\pard\plain
{\trowd\clvertalc\cellx720\clvertalc\cellx10800\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx720\clvertalc\cellx10800\trrh-66\row}}}
{\trowd\cellx720\cellx10800\trrh1458
\pard\plain\intbl\li396\cf1\f51\fs24\ql 5.3.8\cell\pard\plain\intbl\li396\fi-396\cf1\f51\fs24\ql [\u8230?***\u8230?] studies. ). [\u8230?***\u8230?] will be randomized to receive\plain\intbl\li396\cf1\f51\fs24\ql [\u8230?***\u8230?] beginning at the [\u8230?***\u8230?]. These studies will include\plain\intbl\li396\cf1\f51\fs24\ql [\u8230?***\u8230?] and [\u8230?***\u8230?] as well as [\u8230?***\u8230?] including\plain\intbl\li396\cf1\f51\fs24\ql [\u8230?***\u8230?]. The primary endpoint will be [\u8230?***\u8230?].\cell{
{\trowd\cellx720\cellx10800\trrh1458\row}}}
\par\pard\plain\fs16\pard\plain\cf1\f51\fs24\qc 12\par\pard\plain\cf1\f51\fs16\b\qr ***Confidential Treatment Requested\par\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par
\page
\par\pard\plain\fs16
\par\pard\plain\fs16
\par\pard\plain\fs16
\pard\plain
{\trowd\clvertalc\cellx720\clvertalc\cellx10800\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx720\clvertalc\cellx10800\trrh-66\row}}}
{\trowd\cellx720\cellx10800\trrh1188
\pard\plain\intbl\li396\cf1\f51\fs24\ql 5.3.1\cell\pard\plain\intbl\li396\fi-396\cf1\f51\fs24\ql [\u8230?***\u8230?] Studies. This study will determine the [\u8230?***\u8230?] at the\plain\intbl\li396\cf1\f51\fs24\ql [\u8230?***\u8230?]. [\u8230?***\u8230?] and [\u8230?***\u8230?] at the [\u8230?***\u8230?].\plain\intbl\li396\cf1\f51\fs24\ql The primary endpoint will be [\u8230?***\u8230?]. If FDA requires a [\u8230?***\u8230?] in\plain\intbl\li396\cf1\f51\fs24\ql the [\u8230?***\u8230?] studies, the [\u8230?***\u8230?] study may not be needed.\cell{
{\trowd\cellx720\cellx10800\trrh1188\row}}}
\pard\plain
{\trowd\clvertalc\cellx720\clvertalc\cellx10800\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx720\clvertalc\cellx10800\trrh-66\row}}}
{\trowd\cellx720\cellx10800\trrh864
\pard\plain\intbl\li396\cf1\f51\fs24\ql 5.3.2\cell\pard\plain\intbl\li396\fi-396\cf1\f51\fs24\ql Conduct [\u8230?***\u8230?] Studies. This study will determine the [\u8230?***\u8230?] at the\plain\intbl\li396\cf1\f51\fs24\ql [\u8230?***\u8230?]. [\u8230?***\u8230?] and [\u8230?***\u8230?] at the [\u8230?***\u8230?].\cell{
{\trowd\cellx720\cellx10800\trrh864\row}}}
\pard\plain
{\trowd\clvertalc\cellx321\clvertalc\cellx1162\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx321\clvertalc\cellx1162\trrh-66\row}}}
{\trowd\cellx321\cellx1162\trrh567
\pard\plain\intbl\cf1\f51\fs24\b\ql 5.4\cell\pard\plain\intbl\li88\fi-88\cf1\f51\fs24\b\qj Clinical\cell{
{\trowd\cellx321\cellx1162\trrh567\row}}}
\pard\plain
{\trowd\clvertalc\cellx720\clvertalc\cellx10800\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx720\clvertalc\cellx10800\trrh-66\row}}}
{\trowd\cellx720\cellx10800\trrh1782
\pard\plain\intbl\li396\cf1\f51\fs24\ql 5.4.1\cell\pard\plain\intbl\li396\fi-396\cf1\f51\fs24\ql Phase 3 development including [\u8230?***\u8230?] study, [\u8230?***\u8230?] study, phases II\plain\intbl\li396\cf1\f51\fs24\ql [\u8230?***\u8230?] study. A [\u8230?***\u8230?] study will be conducted to compare the\plain\intbl\li396\cf1\f51\fs24\ql [\u8230?***\u8230?] of CMX001 in [\u8230?***\u8230?] to [\u8230?***\u8230?]. A\plain\intbl\li396\cf1\f51\fs24\ql [\u8230?***\u8230?] study will be conducted to compare the [\u8230?***\u8230?] of CMX001\plain\intbl\li396\cf1\f51\fs24\ql when [\u8230?***\u8230?]. A [\u8230?***\u8230?] study will be conducted to\plain\intbl\li396\cf1\f51\fs24\ql [\u8230?***\u8230?] to support an NDA.\cell{
{\trowd\cellx720\cellx10800\trrh1782\row}}}
\pard\plain
{\trowd\clvertalc\cellx720\clvertalc\cellx10800\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx720\clvertalc\cellx10800\trrh-66\row}}}
{\trowd\cellx720\cellx10800\trrh594
\pard\plain\intbl\li396\cf1\f51\fs24\ql 5.4.2\cell\pard\plain\intbl\li396\fi-396\cf1\f51\fs24\ql Measurement of [\u8230?***\u8230?] in [\u8230?***\u8230?] and correlate the [\u8230?***\u8230?]\plain\intbl\li396\cf1\f51\fs24\ql to studies conducted in [\u8230?***\u8230?] (if required)\cell{
{\trowd\cellx720\cellx10800\trrh594\row}}}
\pard\plain
{\trowd\clvertalc\cellx720\clvertalc\cellx10800\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx720\clvertalc\cellx10800\trrh-66\row}}}
{\trowd\cellx720\cellx10800\trrh1161
\pard\plain\intbl\li396\cf1\f51\fs24\ql 5.4.3\cell\pard\plain\intbl\li396\fi-396\cf1\f51\fs24\ql Compile [\u8230?***\u8230?] for NDA submission. A [\u8230?***\u8230?] collected from all\plain\intbl\li396\cf1\f51\fs24\ql CMX001 studies, irrespective of indication, will be populated and analyzed in order to support an\plain\intbl\li396\cf1\f51\fs24\ql NDA for smallpox.\cell{
{\trowd\cellx720\cellx10800\trrh1161\row}}}
\pard\plain
{\trowd\clvertalc\cellx321\clvertalc\cellx1509\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx321\clvertalc\cellx1509\trrh-66\row}}}
{\trowd\cellx321\cellx1509\trrh297
\pard\plain\intbl\cf1\f51\fs24\b\ql 5.5\cell\pard\plain\intbl\li88\fi-88\cf1\f51\fs24\b\qj Regulatory\cell{
{\trowd\cellx321\cellx1509\trrh297\row}}}
\pard\plain
{\trowd\clvertalc\cellx720\clvertalc\cellx10800\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx720\clvertalc\cellx10800\trrh-66\row}}}
{\trowd\cellx720\cellx10800\trrh594
\pard\plain\intbl\li396\cf1\f51\fs24\ql 5.5.1\cell\pard\plain\intbl\li396\fi-396\cf1\f51\fs24\ql Generating all necessary data and preparing documentation for NDA submissions to regulatory\plain\intbl\li396\cf1\f51\fs24\ql agencies;\cell{
{\trowd\cellx720\cellx10800\trrh594\row}}}
\pard\plain
{\trowd\clvertalc\cellx720\clvertalc\cellx10800\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx720\clvertalc\cellx10800\trrh-66\row}}}
{\trowd\cellx720\cellx10800\trrh594
\pard\plain\intbl\li396\cf1\f51\fs24\ql 5.5.2\cell\pard\plain\intbl\li396\fi-396\cf1\f51\fs24\ql Preparing materials for and requesting, scheduling and participating in all meetings with the FDA,\plain\intbl\li396\cf1\f51\fs24\ql including meetings to review IND, NDA and/or all other data packages;\cell{
{\trowd\cellx720\cellx10800\trrh594\row}}}
\pard\plain
{\trowd\clvertalc\cellx720\clvertalc\cellx10800\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx720\clvertalc\cellx10800\trrh-66\row}}}
{\trowd\cellx720\cellx10800\trrh594
\pard\plain\intbl\li396\cf1\f51\fs24\ql 5.5.3\cell\pard\plain\intbl\li396\fi-396\cf1\f51\fs24\ql Providing BARDA with (i) the initial draft minutes and final draft minutes of any formal meeting\plain\intbl\li396\cf1\f51\fs24\ql with the FDA; (ii) final draft minutes of any informal meeting with the FDA\cell{
{\trowd\cellx720\cellx10800\trrh594\row}}}
\par\pard\plain\fs16
\pard\plain
{\trowd\clvertalc\cellx321\clvertalc\cellx934\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx321\clvertalc\cellx934\trrh-66\row}}}
{\trowd\cellx321\cellx934\trrh297
\pard\plain\intbl\cf1\f51\fs24\b\ql 5.6\cell\pard\plain\intbl\li88\fi-88\cf1\f51\fs24\b\qj CMC\cell{
{\trowd\cellx321\cellx934\trrh297\row}}}
\pard\plain
{\trowd\clvertalc\cellx720\clvertalc\cellx10800\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx720\clvertalc\cellx10800\trrh-66\row}}}
{\trowd\cellx720\cellx10800\trrh864
\pard\plain\intbl\li396\cf1\f51\fs24\ql 5.6.1\cell\pard\plain\intbl\li396\fi-396\cf1\f51\fs24\ql [\u8230?***\u8230?]. [\u8230?***\u8230?] of the process to demonstrate the [\u8230?***\u8230?] of\plain\intbl\li396\cf1\f51\fs24\ql a [\u8230?***\u8230?] will be performed.\cell{
{\trowd\cellx720\cellx10800\trrh864\row}}}
\par\pard\plain\fs16\pard\plain\cf1\f51\fs24\qc 13\par\pard\plain\cf1\f51\fs16\b\qr ***Confidential Treatment Requested\par\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par
\page
\par\pard\plain\fs16
\par\pard\plain\fs16
\par\pard\plain\fs16
\pard\plain
{\trowd\clvertalc\cellx228\clvertalc\cellx3211\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx228\clvertalc\cellx3211\trrh-66\row}}}
{\trowd\cellx228\cellx3211\trrh594
\pard\plain\intbl\cf1\f51\fs24\b\ql 6.\cell\pard\plain\intbl\cf1\f51\fs24\b\qj PHASE V:\plain\intbl\cf1\f51\fs24\b\qj [\plain\intbl\cf1\f51\fs24\qj \u8230?***\u8230?\plain\intbl\cf1\f51\fs24\b\qj ]\cell{
{\trowd\cellx228\cellx3211\trrh594\row}}}
\par\pard\plain\fs16\pard\plain\li198\cf1\f51\fs24\ql Research and development of CMX-001 for the treatment of smallpox to include the following activities:\plain\li198\cf1\f51\fs24\ql [\u8230?***\u8230?]. The contractor shall carry out the following tasks and subtasks and in accordance\plain\li198\cf1\f51\fs24\ql with an agreed upon Integrated Master Schedule and Integrated Master Plan (defined in 2.1.8 and 2.1.9)\plain\li198\sa264\cf1\f51\fs24\ql which shall further detail the conduct of the specific tasks and subtasks.
\par\pard\plain
{\trowd\clvertalc\cellx495\clvertalc\cellx5014\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx495\clvertalc\cellx5014\trrh-66\row}}}
{\trowd\cellx495\cellx5014\trrh594
\pard\plain\intbl\cf1\f51\fs24\b\ql 6.1\cell\pard\plain\intbl\li88\fi-88\cf1\f51\fs24\b\qj Program Management\plain\intbl\li88\cf1\f51\fs24\qj (Consistent with\plain\intbl\li88\cf1\f51\fs24\qj section 2.1)\cell{
{\trowd\cellx495\cellx5014\trrh594\row}}}
\pard\plain
{\trowd\clvertalc\cellx720\clvertalc\cellx10800\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx720\clvertalc\cellx10800\trrh-66\row}}}
{\trowd\cellx720\cellx10800\trrh864
\pard\plain\intbl\li396\cf1\f51\fs24\ql 6.1.1\cell\pard\plain\intbl\li396\fi-396\cf1\f51\fs24\ql Program management scope in BASE year is consistent with program management scope in each\plain\intbl\li396\cf1\f51\fs24\ql option year.\cell{
{\trowd\cellx720\cellx10800\trrh864\row}}}
\pard\plain
{\trowd\clvertalc\cellx371\clvertalc\cellx2483\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx371\clvertalc\cellx2483\trrh-66\row}}}
{\trowd\cellx371\cellx2483\trrh594
\pard\plain\intbl\cf1\f51\fs24\b\ql 6.2\cell\pard\plain\intbl\li88\fi-88\cf1\f51\fs24\b\qj Non-Clinical\plain\intbl\li88\cf1\f51\fs24\b\qj toxicology\cell{
{\trowd\cellx371\cellx2483\trrh594\row}}}
\pard\plain
{\trowd\clvertalc\cellx520\clvertalc\cellx1757\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx520\clvertalc\cellx1757\trrh-66\row}}}
{\trowd\cellx520\cellx1757\trrh864
\pard\plain\intbl\li396\cf1\f51\fs24\ql 6.2.3\cell\pard\plain\intbl\li396\fi-396\cf1\f51\fs24\ql N/A (no\plain\intbl\li396\cf1\f51\fs24\ql scope)\cell{
{\trowd\cellx520\cellx1757\trrh864\row}}}
\pard\plain
{\trowd\clvertalc\cellx321\clvertalc\cellx1726\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx321\clvertalc\cellx1726\trrh-66\row}}}
{\trowd\cellx321\cellx1726\trrh297
\pard\plain\intbl\cf1\f51\fs24\b\ql 6.3\cell\pard\plain\intbl\li88\fi-88\cf1\f51\fs24\b\qj Non-Clinical\cell{
{\trowd\cellx321\cellx1726\trrh297\row}}}
\pard\plain
{\trowd\clvertalc\cellx720\clvertalc\cellx10800\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx720\clvertalc\cellx10800\trrh-66\row}}}
{\trowd\cellx720\cellx10800\trrh864
\pard\plain\intbl\li396\cf1\f51\fs24\ql 6.3.4\cell\pard\plain\intbl\li396\fi-396\cf1\f51\fs24\ql [\u8230?***\u8230?] Studies. This study replicates [\u8230?***\u8230?] if a larger sample size is\plain\intbl\li396\cf1\f51\fs24\ql necessary to achieve a [\u8230?***\u8230?] result.\cell{
{\trowd\cellx720\cellx10800\trrh864\row}}}
\pard\plain
{\trowd\clvertalc\cellx321\clvertalc\cellx1162\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx321\clvertalc\cellx1162\trrh-66\row}}}
{\trowd\cellx321\cellx1162\trrh297
\pard\plain\intbl\cf1\f51\fs24\b\ql 6.4\cell\pard\plain\intbl\li88\fi-88\cf1\f51\fs24\b\qj Clinical\cell{
{\trowd\cellx321\cellx1162\trrh297\row}}}
\pard\plain
{\trowd\clvertalc\cellx720\clvertalc\cellx10800\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx720\clvertalc\cellx10800\trrh-66\row}}}
{\trowd\cellx720\cellx10800\trrh1161
\pard\plain\intbl\li396\cf1\f51\fs24\ql 6.4.4\cell\pard\plain\intbl\li396\fi-396\cf1\f51\fs24\ql Compile [\u8230?***\u8230?]. A database of [\u8230?***\u8230?] data collected from all CMX001\plain\intbl\li396\cf1\f51\fs24\ql clinical studies, irrespective of [\u8230?***\u8230?], will be populated and analyzed in order to\plain\intbl\li396\cf1\f51\fs24\ql support an NDA for smallpox.\cell{
{\trowd\cellx720\cellx10800\trrh1161\row}}}
\pard\plain
{\trowd\clvertalc\cellx321\clvertalc\cellx1509\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx321\clvertalc\cellx1509\trrh-66\row}}}
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\pard\plain\intbl\cf1\f51\fs24\b\ql 6.5\cell\pard\plain\intbl\li88\fi-88\cf1\f51\fs24\b\qj Regulatory\cell{
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\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
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\pard\plain\intbl\li396\cf1\f51\fs24\ql 6.5.2\cell\pard\plain\intbl\li396\fi-396\cf1\f51\fs24\ql Generating all necessary data and preparing documentation for NDA submissions to regulatory\plain\intbl\li396\cf1\f51\fs24\ql agencies;\cell{
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\pard\plain
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\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
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{\trowd\cellx720\cellx10800\trrh594
\pard\plain\intbl\li396\cf1\f51\fs24\ql 6.5.3\cell\pard\plain\intbl\li396\fi-396\cf1\f51\fs24\ql Submitting NDA documentation to the FDA in a timely manner, consistent with timelines set out in\plain\intbl\li396\cf1\f51\fs24\ql the contract and by the FDA.\cell{
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\pard\plain
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\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
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\pard\plain\intbl\li396\cf1\f51\fs24\ql 6.5.4\cell\pard\plain\intbl\li396\fi-396\cf1\f51\fs24\ql Preparing materials for and requesting, scheduling and participating in all meetings with the FDA,\plain\intbl\li396\cf1\f51\fs24\ql including meetings to review IND, EUA and/or all other data packages;\cell{
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\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
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{\trowd\cellx720\cellx10800\trrh864
\pard\plain\intbl\li396\cf1\f51\fs24\ql 6.5.5\cell\pard\plain\intbl\li396\fi-396\cf1\f51\fs24\ql Providing BARDA with (i) the initial draft minutes and final draft minutes of any formal meeting\plain\intbl\li396\cf1\f51\fs24\ql with the FDA; (ii) final draft minutes of any informal meeting with the FDA;\cell{
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{\trowd\cellx321\cellx894\trrh297
\pard\plain\intbl\cf1\f51\fs24\b\ql 6.6\cell\pard\plain\intbl\li88\fi-88\cf1\f51\fs24\qj CMC\cell{
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{\trowd\clvertalc\cellx720\clvertalc\cellx10800\trrh-66
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{\trowd\cellx720\cellx10800\trrh864
\pard\plain\intbl\li396\cf1\f51\fs24\ql 6.6.1\cell\pard\plain\intbl\li396\fi-396\cf1\f51\fs24\ql [\u8230?***\u8230?]. [\u8230?***\u8230?] of the process to demonstrate the [\u8230?***\u8230?] of\plain\intbl\li396\cf1\f51\fs24\ql a [\u8230?***\u8230?] will be performed.\cell{
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\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
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{\trowd\cellx210\cellx1259\trrh864
\pard\plain\intbl\cf1\f51\fs24\b\ql 7.\cell\pard\plain\intbl\cf1\f51\fs24\b\qj Other\plain\intbl\cf1\f51\fs24\b\qj Items\cell{
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\par\pard\plain\fs16\pard\plain\cf1\f51\fs24\qc 14\par\pard\plain\cf1\f51\fs16\b\qr ***Confidential Treatment Requested\par\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par
\page
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\pard\plain\intbl\cf1\f51\fs24\b\ql 7.1\cell\pard\plain\intbl\li88\fi-88\cf1\f51\fs24\b\qj Facilities, Equipment and Other Resources. (Contract:\plain\intbl\li88\cf1\f51\fs24\b\qj Section J)\cell{
{\trowd\cellx569\cellx6757\trrh594\row}}}\pard\plain\li792\cf1\f51\fs24\ql The Contractor shall provide equipment; facilities and other resources required for implementation of\plain\li792\sa264\cf1\f51\fs24\ql the SOW dated 27-OCT-14 to comply with all Federal and HHS regulations in:
\par\pard\plain
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\pard\plain\intbl\li396\cf1\f51\fs24\ql 7.1.4\cell\pard\plain\intbl\li396\fi-396\cf1\f51\fs24\ql The [\u8230?***\u8230?] and use of\plain\intbl\li396\cf1\f51\fs24\ql [\u8230?***\u8230?];\cell{
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{\trowd\clvertalc\cellx720\clvertalc\cellx10800\trrh-66
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\pard\plain\intbl\li396\cf1\f51\fs24\ql 7.1.5\cell\pard\plain\intbl\li396\fi-396\cf1\f51\fs24\ql The acquisition, handling, storage and shipment of [\u8230?***\u8230?], including\plain\intbl\li396\cf1\f51\fs24\ql [\u8230?***\u8230?] required for working with the [\u8230?***\u8230?];\cell{
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\pard\plain
{\trowd\clvertalc\cellx617\clvertalc\cellx6624\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
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\pard\plain\intbl\li396\cf1\f51\fs24\ql 7.1.6\cell\pard\plain\intbl\li396\fi-396\cf1\f51\fs24\ql The [\u8230?***\u8230?] of [\u8230?***\u8230?] under\plain\intbl\li396\cf1\f51\fs24\ql cGMP;\cell{
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\pard\plain
{\trowd\clvertalc\cellx1093\clvertalc\cellx5830\trrh-66
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\pard\plain\intbl\li792\cf1\f51\fs24\ql 7.1.6.1\cell\pard\plain\intbl\li22\fi-22\cf1\f51\fs24\ql The design and conduct of\plain\intbl\li22\cf1\f51\fs24\ql [\u8230?***\u8230?]; and\cell{
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\pard\plain
{\trowd\clvertalc\cellx1695\clvertalc\cellx10800\trrh-66
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\pard\plain\intbl\li792\cf1\f51\fs24\ql 7.1.6.2\cell\pard\plain\intbl\li22\fi-22\cf1\f51\fs24\ql The conduct of [\u8230?***\u8230?] studies to determine [\u8230?***\u8230?] of\plain\intbl\li22\cf1\f51\fs24\ql [\u8230?***\u8230?]\cell{
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\par\pard\plain\fs16
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\pard\plain\intbl\li396\cf1\f51\fs24\ql 7.1.7\cell\pard\plain\intbl\li396\fi-396\cf1\f51\fs24\ql Design and conduct of [\u8230?***\u8230?] under\plain\intbl\li396\cf1\f51\fs24\ql GCP.\cell{
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\par\pard\plain\fs16
\par\pard\plain\fs16\pard\plain\cf1\f51\fs24\qc 15\par\pard\plain\cf1\f51\fs16\b\qr ***Confidential Treatment Requested\par\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par
\page{\*\bkmkstart s8E822460E75244FAC715B43B9877C6F}{\*\bkmkend s8E822460E75244FAC715B43B9877C6F}
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\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
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\pard\plain\intbl\li22\ri22\sb132\sa132\cf1\f52\fs21\qc REVISED MILESTONES ARTICLE F.2 DELIVERABLES\cell{
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\pard\plain\intbl\li22\ri22\sb22\cf1\f52\fs17\qc Current
\par\pard\plain\intbl\fs16\pard\plain\intbl\li22\ri22\cf1\f52\fs17\qc Milestone\plain\intbl\li22\ri22\sa22\cf1\f52\fs17\qc #\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs17\qc Milestone Definition\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs17\qc Go Criteria\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs17\qc No-Go Criteria\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs17\qc Deliverable\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs17\qc WBS/SOW #\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs17\qc Segment\cell{
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\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs17\ql \u8226?\cell\pard\plain\intbl\li22\ri22\cf1\f52\fs17\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\cf1\f52\fs17\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs17\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs17\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs17\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs17\ql [\u8230?***\u8230?]\cell{
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{\trowd\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx871\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx2525\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx4179\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx5833\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx7487\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx9141\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx10795\trrh907
\pard\plain\intbl\li22\ri22\sb22\cf1\f52\fs17\qc 2.\plain\intbl\li22\ri22\sa264\cf1\f51\fs18\qc \~\~\~\~\cell\pard\plain\intbl\li22\ri22\cf1\f52\fs17\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\cf1\f52\fs17\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs17\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs17\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs17\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs17\ql [\u8230?***\u8230?]\cell{
{\trowd\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx871\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx2525\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx4179\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx5833\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx7487\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx9141\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx10795\trrh907\row}}}
{\trowd\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx871\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx2525\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx4179\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx5833\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx7487\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx9141\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx10795\trrh907
\pard\plain\intbl\li22\ri22\sb22\cf1\f52\fs17\qc 3.\plain\intbl\li22\ri22\sa264\cf1\f51\fs18\qc \~\~\~\~\cell\pard\plain\intbl\li22\ri22\cf1\f52\fs17\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs17\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs17\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs17\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs17\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs17\ql [\u8230?***\u8230?]\cell{
{\trowd\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx871\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx2525\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx4179\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx5833\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx7487\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx9141\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx10795\trrh907\row}}}
{\trowd\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx871\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx2525\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx4179\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx5833\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx7487\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx9141\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx10795\trrh907
\pard\plain\intbl\li22\ri22\sb22\cf1\f52\fs17\qc 4.\plain\intbl\li22\ri22\sa264\cf1\f51\fs18\qc \~\~\~\~\cell\pard\plain\intbl\li22\ri22\cf1\f52\fs17\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs17\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs17\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs17\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs17\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs17\ql [\u8230?***\u8230?]\cell{
{\trowd\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx871\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx2525\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx4179\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx5833\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx7487\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx9141\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx10795\trrh907\row}}}
{\trowd\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx871\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx2525\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx4179\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx5833\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx7487\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx9141\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx10795\trrh907
\pard\plain\intbl\li22\ri22\sb22\cf1\f52\fs17\qc 5.\plain\intbl\li22\ri22\sa264\cf1\f51\fs18\qc \~\~\~\~\cell\pard\plain\intbl\li22\ri66\cf1\f52\fs17\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs17\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs17\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs17\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs17\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs17\ql [\u8230?***\u8230?]\cell{
{\trowd\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx871\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx2525\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx4179\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx5833\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx7487\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx9141\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx10795\trrh907\row}}}
{\trowd\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx871\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\clvertalb\cellx2525\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\clvertalb\cellx4179\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx5833\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\clvertalb\cellx7487\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\clvertalb\cellx9141\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\clvertalb\cellx10795\trrh1797
\par\pard\plain\intbl\fs16
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs18\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs18\ql \~\cell\pard\plain\intbl\li22\ri264\sa22\cf1\f52\fs17\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs18\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs18\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs18\ql \~\cell{
{\trowd\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx871\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\clvertalb\cellx2525\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\clvertalb\cellx4179\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx5833\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\clvertalb\cellx7487\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\clvertalb\cellx9141\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\clvertalb\cellx10795\trrh1797\row}}}
{\trowd\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx871\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx2525\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx4179\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx5833\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx7487\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx9141\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx10795\trrh907
\pard\plain\intbl\li22\ri22\sb22\cf1\f52\fs17\qc 6.\plain\intbl\li22\ri22\sa264\cf1\f51\fs18\qc \~\~\~\~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs17\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs17\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs17\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs17\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs17\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs17\ql [\u8230?***\u8230?]\cell{
{\trowd\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx871\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx2525\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx4179\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx5833\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx7487\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx9141\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx10795\trrh907\row}}}
{\trowd\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx871\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx2525\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx4179\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx5833\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx7487\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx9141\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx10795\trrh907
\pard\plain\intbl\li22\ri22\sb22\cf1\f52\fs17\qc 7.\plain\intbl\li22\ri22\sa264\cf1\f51\fs18\qc \~\~\~\~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs17\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs17\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs17\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs17\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs17\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs17\ql [\u8230?***\u8230?]\cell{
{\trowd\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx871\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx2525\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx4179\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx5833\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx7487\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx9141\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx10795\trrh907\row}}}
{\trowd\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx871\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx2525\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx4179\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx5833\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx7487\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx9141\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx10795\trrh907
\pard\plain\intbl\li22\ri22\sb22\cf1\f52\fs17\qc 8.\plain\intbl\li22\ri22\sa264\cf1\f51\fs18\qc \~\~\~\~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs17\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs17\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs17\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs17\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs17\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs17\ql [\u8230?***\u8230?]\cell{
{\trowd\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx871\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx2525\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx4179\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx5833\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx7487\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx9141\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx10795\trrh907\row}}}
{\trowd\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\clvertalb\cellx871\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx2525\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx4179\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx5833\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\clvertalb\cellx7487\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\clvertalb\cellx9141\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\clvertalb\cellx10795\trrh1135
\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs18\ql \~\cell
\par\pard\plain\intbl\fs16
\par\pard\plain\intbl\fs16
\par\pard\plain\intbl\fs16
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri484\cf1\f52\fs17\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\cf1\f52\fs17\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs18\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs18\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs18\ql \~\cell{
{\trowd\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\clvertalb\cellx871\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx2525\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx4179\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx5833\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\clvertalb\cellx7487\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\clvertalb\cellx9141\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\clvertalb\cellx10795\trrh1135\row}}}
{\trowd\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx871\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx2525\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\clvertalb\cellx4179\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\clvertalb\cellx5833\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\clvertalb\cellx7487\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx9141\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx10795\trrh907
\pard\plain\intbl\li22\ri22\sb22\cf1\f52\fs17\qc 9.\plain\intbl\li22\ri22\sa264\cf1\f51\fs18\qc \~\~\~\~\cell\pard\plain\intbl\li22\ri22\cf1\f52\fs17\ql No longer in\plain\intbl\li22\ri22\cf1\f52\fs17\ql development plan.\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs18\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs18\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs18\ql \~\cell\pard\plain\intbl\li22\ri22\cf1\f52\fs17\ql N/A\cell\pard\plain\intbl\li22\ri22\cf1\f52\fs17\ql N/A\cell{
{\trowd\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx871\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx2525\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\clvertalb\cellx4179\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\clvertalb\cellx5833\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\clvertalb\cellx7487\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx9141\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx10795\trrh907\row}}}
{\trowd\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx871\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx2525\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\clvertalb\cellx4179\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\clvertalb\cellx5833\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\clvertalb\cellx7487\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx9141\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx10795\trrh907
\pard\plain\intbl\li22\ri22\sb22\cf1\f52\fs17\qc 10.\plain\intbl\li22\ri22\sa264\cf1\f51\fs18\qc \~\~\~\~\cell\pard\plain\intbl\li22\ri22\cf1\f52\fs17\ql No longer in\plain\intbl\li22\ri22\cf1\f52\fs17\ql development plan.\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs18\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs18\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs18\ql \~\cell\pard\plain\intbl\li22\ri22\cf1\f52\fs17\ql N/A\cell\pard\plain\intbl\li22\ri22\cf1\f52\fs17\ql N/A\cell{
{\trowd\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx871\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx2525\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\clvertalb\cellx4179\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\clvertalb\cellx5833\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\clvertalb\cellx7487\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx9141\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx10795\trrh907\row}}}
{\trowd\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx871\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx2525\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx4179\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx5833\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx7487\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx9141\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx10795\trrh907
\pard\plain\intbl\li22\ri22\sb22\cf1\f52\fs17\qc 11.\plain\intbl\li22\ri22\sa264\cf1\f51\fs18\qc \~\~\~\~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs17\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs17\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs17\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs17\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs17\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs17\ql [\u8230?***\u8230?]\cell{
{\trowd\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx871\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx2525\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx4179\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx5833\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx7487\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx9141\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx10795\trrh907\row}}}
{\trowd\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx871\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx2525\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\clvertalb\cellx4179\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\clvertalb\cellx5833\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\clvertalb\cellx7487\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx9141\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx10795\trrh907
\pard\plain\intbl\li22\ri22\sb22\cf1\f52\fs17\qc 12.\plain\intbl\li22\ri22\sa264\cf1\f51\fs18\qc \~\~\~\~\cell\pard\plain\intbl\li22\ri22\cf1\f52\fs17\ql No longer in\plain\intbl\li22\ri22\cf1\f52\fs17\ql development plan.\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs18\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs18\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs18\ql \~\cell\pard\plain\intbl\li22\ri22\cf1\f52\fs17\ql N/A\cell\pard\plain\intbl\li22\ri22\cf1\f52\fs17\ql N/A\cell{
{\trowd\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx871\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx2525\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\clvertalb\cellx4179\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\clvertalb\cellx5833\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\clvertalb\cellx7487\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx9141\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx10795\trrh907\row}}}
{\trowd\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx871\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx2525\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\clvertalb\cellx4179\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\clvertalb\cellx5833\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\clvertalb\cellx7487\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx9141\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx10795\trrh907
\pard\plain\intbl\li22\ri22\sb22\cf1\f52\fs17\qc 13.\plain\intbl\li22\ri22\sa264\cf1\f51\fs18\qc \~\~\~\~\cell\pard\plain\intbl\li22\ri22\cf1\f52\fs17\ql No longer in\plain\intbl\li22\ri22\cf1\f52\fs17\ql development plan.\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs18\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs18\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs18\ql \~\cell\pard\plain\intbl\li22\ri22\cf1\f52\fs17\ql N/A\cell\pard\plain\intbl\li22\ri22\cf1\f52\fs17\ql N/A\cell{
{\trowd\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx871\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx2525\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\clvertalb\cellx4179\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\clvertalb\cellx5833\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\clvertalb\cellx7487\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx9141\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx10795\trrh907\row}}}
{\trowd\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx871\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx2525\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx4179\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx5833\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx7487\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx9141\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx10795\trrh907
\pard\plain\intbl\li22\ri22\sb22\cf1\f52\fs17\qc 14.\plain\intbl\li22\ri22\sa264\cf1\f51\fs18\qc \~\~\~\~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs17\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs17\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs17\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs17\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs17\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs17\ql [\u8230?***\u8230?]\cell{
{\trowd\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx871\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx2525\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx4179\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx5833\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx7487\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx9141\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx10795\trrh907\row}}}
{\trowd\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx871\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx2525\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx4179\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx5833\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx7487\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx9141\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx10795\trrh907
\pard\plain\intbl\li22\ri22\sb22\cf1\f52\fs17\qc 15.\plain\intbl\li22\ri22\sa264\cf1\f51\fs18\qc \~\~\~\~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs17\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs17\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs17\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs17\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs17\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs17\ql [\u8230?***\u8230?]\cell{
{\trowd\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx871\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx2525\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx4179\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx5833\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx7487\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx9141\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx10795\trrh907\row}}}
{\trowd\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx871\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\clvertalb\cellx2525\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\clvertalb\cellx4179\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx5833\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\clvertalb\cellx7487\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\clvertalb\cellx9141\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\clvertalb\cellx10795\trrh1797
\par\pard\plain\intbl\fs16
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs18\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs18\ql \~\cell\pard\plain\intbl\li22\ri330\cf1\f52\fs17\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs18\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs18\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs18\ql \~\cell{
{\trowd\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx871\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\clvertalb\cellx2525\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\clvertalb\cellx4179\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx5833\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\clvertalb\cellx7487\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\clvertalb\cellx9141\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\clvertalb\cellx10795\trrh1797\row}}}
{\trowd\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx871\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx2525\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx4179\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx5833\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx7487\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx9141\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx10795\trrh907
\pard\plain\intbl\li22\ri22\sb22\cf1\f52\fs17\qc 16.\plain\intbl\li22\ri22\sa264\cf1\f51\fs18\qc \~\~\~\~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs17\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs17\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs17\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs17\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs17\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs17\ql [\u8230?***\u8230?]\cell{
{\trowd\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx871\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx2525\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx4179\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx5833\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx7487\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx9141\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx10795\trrh907\row}}}
{\trowd\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx871\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx2525\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\clvertalb\cellx4179\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\clvertalb\cellx5833\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\clvertalb\cellx7487\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx9141\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx10795\trrh907
\pard\plain\intbl\li22\ri22\sb22\cf1\f52\fs17\qc 17.\plain\intbl\li22\ri22\sa264\cf1\f51\fs18\qc \~\~\~\~\cell\pard\plain\intbl\li22\ri22\cf1\f52\fs17\ql No longer in\plain\intbl\li22\ri22\cf1\f52\fs17\ql development plan.\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs18\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs18\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs18\ql \~\cell\pard\plain\intbl\li22\ri22\cf1\f52\fs17\ql N/A\cell\pard\plain\intbl\li22\ri22\cf1\f52\fs17\ql N/A\cell{
{\trowd\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx871\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx2525\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\clvertalb\cellx4179\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\clvertalb\cellx5833\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\clvertalb\cellx7487\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx9141\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx10795\trrh907\row}}}
{\trowd\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx871\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx2525\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx4179\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx5833\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx7487\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx9141\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx10795\trrh907
\pard\plain\intbl\li22\ri22\sb22\cf1\f52\fs17\qc 18.\plain\intbl\li22\ri22\sa264\cf1\f51\fs18\qc \~\~\~\~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs17\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs17\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs17\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs17\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs17\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs17\ql [\u8230?***\u8230?]\cell{
{\trowd\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx871\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx2525\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx4179\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx5833\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx7487\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx9141\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx10795\trrh907\row}}}
{\trowd\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx871\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx2525\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx4179\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx5833\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx7487\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx9141\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx10795\trrh907
\pard\plain\intbl\li22\ri22\sb22\cf1\f52\fs17\qc 19.\plain\intbl\li22\ri22\sa264\cf1\f51\fs18\qc \~\~\~\~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs17\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs17\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs17\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs17\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs17\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs17\ql [\u8230?***\u8230?]\cell{
{\trowd\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx871\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx2525\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx4179\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx5833\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx7487\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx9141\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx10795\trrh907\row}}}
\par\pard\plain\fs16\pard\plain\cf1\f51\fs16\b\qr ***Confidential Treatment Requested
\par\pard\plain\fs16\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par
\page
\par\pard\plain\fs16
\par\pard\plain\fs16
\par\pard\plain\fs16
\par\pard\plain
{\trowd\clvertalc\cellx10800\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx10800\trrh-66\row}}}
{\trowd\clvertalc\cellx1039\clvertalc\cellx2540\clvertalc\cellx4041\clvertalc\cellx4791\clvertalc\cellx6292\clvertalc\cellx7793\clvertalc\cellx9294\clvertalc\cellx10795\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx1039\clvertalc\cellx2540\clvertalc\cellx4041\clvertalc\cellx4791\clvertalc\cellx6292\clvertalc\cellx7793\clvertalc\cellx9294\clvertalc\cellx10795\trrh-66\row}}}
{\trowd\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx1039\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\clvertalb\cellx2540\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\clvertalb\cellx4792\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx6293\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\clvertalb\cellx7794\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\clvertalb\cellx9295\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\clvertalb\cellx10796\trrh1752
\par\pard\plain\intbl\fs16
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs16\ql \~\cell\pard\plain\intbl\li22\ri330\cf1\f52\fs15\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs16\ql \~\cell{
{\trowd\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx1039\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\clvertalb\cellx2540\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\clvertalb\cellx4792\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx6293\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\clvertalb\cellx7794\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\clvertalb\cellx9295\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\clvertalb\cellx10796\trrh1752\row}}}
{\trowd\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx1039\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx2540\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx4792\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx6293\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx7794\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx9295\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx10796\trrh886
\pard\plain\intbl\li22\ri22\sb22\cf1\f52\fs15\qc 20.\plain\intbl\li22\ri22\sa264\cf1\f51\fs16\qc \~\~\~\~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs15\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs15\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs15\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs15\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs15\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs15\ql [\u8230?***\u8230?]\cell{
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{\trowd\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx1039\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx2540\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx4792\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx6293\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx7794\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx9295\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx10796\trrh886
\pard\plain\intbl\li22\ri22\sb22\cf1\f52\fs15\qc 21.\plain\intbl\li22\ri22\sa264\cf1\f51\fs16\qc \~\~\~\~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs15\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs15\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs15\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs15\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs15\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs15\ql [\u8230?***\u8230?]\cell{
{\trowd\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx1039\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx2540\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx4792\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx6293\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx7794\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx9295\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx10796\trrh886\row}}}
{\trowd\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx1039\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx2540\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx4792\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx6293\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx7794\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx9295\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx10796\trrh886
\pard\plain\intbl\li22\ri22\sb22\cf1\f52\fs15\qc 22.\plain\intbl\li22\ri22\sa264\cf1\f51\fs16\qc \~\~\~\~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs15\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs15\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs15\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs15\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs15\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs15\ql [\u8230?***\u8230?]\cell{
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{\trowd\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx1039\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx2540\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx4792\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx6293\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx7794\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx9295\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx10796\trrh886
\pard\plain\intbl\li22\ri22\sb22\cf1\f52\fs15\qc 23.\plain\intbl\li22\ri22\sa264\cf1\f51\fs16\qc \~\~\~\~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs15\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs15\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs15\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs15\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs15\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs15\ql [\u8230?***\u8230?]\cell{
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{\trowd\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx1039\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx2540\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx4792\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx6293\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx7794\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx9295\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx10796\trrh886
\pard\plain\intbl\li22\ri22\sb22\cf1\f52\fs15\qc 24.\plain\intbl\li22\ri22\sa264\cf1\f51\fs16\qc \~\~\~\~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs15\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs15\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs15\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs15\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs15\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs15\ql [\u8230?***\u8230?]\cell{
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{\trowd\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx1039\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\clvertalb\cellx2540\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx4792\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\clvertalb\cellx6293\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\clvertalb\cellx7794\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\clvertalb\cellx9295\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\clvertalb\cellx10796\trrh1752
\par\pard\plain\intbl\fs16
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs16\ql \~\cell\pard\plain\intbl\li22\ri484\cf1\f52\fs15\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs16\ql \~\cell{
{\trowd\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx1039\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\clvertalb\cellx2540\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx4792\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\clvertalb\cellx6293\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\clvertalb\cellx7794\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\clvertalb\cellx9295\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\clvertalb\cellx10796\trrh1752\row}}}
{\trowd\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx1039\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx2540\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx4792\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx6293\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx7794\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx9295\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx10796\trrh886
\pard\plain\intbl\li22\ri22\sb22\cf1\f52\fs15\qc 25.\plain\intbl\li22\ri22\sa264\cf1\f51\fs16\qc \~\~\~\~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs15\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs15\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs15\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs15\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs15\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs15\ql [\u8230?***\u8230?]\cell{
{\trowd\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx1039\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx2540\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx4792\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx6293\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx7794\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx9295\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx10796\trrh886\row}}}
{\trowd\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx1039\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx2540\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx4792\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx6293\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx7794\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx9295\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx10796\trrh886
\pard\plain\intbl\li22\ri22\sb22\cf1\f52\fs15\qc 26.\plain\intbl\li22\ri22\sa264\cf1\f51\fs16\qc \~\~\~\~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs15\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs15\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs15\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs15\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs15\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs15\ql [\u8230?***\u8230?]\cell{
{\trowd\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx1039\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx2540\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx4792\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx6293\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx7794\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx9295\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx10796\trrh886\row}}}
{\trowd\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx1039\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx2540\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx4792\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx6293\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx7794\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx9295\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx10796\trrh463
\pard\plain\intbl\li22\ri22\cf1\f52\fs15\qc BCA\plain\intbl\li22\ri22\cf1\f52\fs15\qc MILESTONE\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs15\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs15\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs15\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs15\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs15\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs15\ql [\u8230?***\u8230?]\cell{
{\trowd\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx1039\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx2540\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx4792\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx6293\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx7794\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx9295\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx10796\trrh463\row}}}
{\trowd\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx10800\trrh662
\pard\plain\intbl\li22\ri22\sb132\sa132\cf1\f52\fs15\qc NEW OPTION 1 MILESTONE TO BE ADDED TO ARTICLE F.2 DELIVERABLES OF THE CONTRACT\cell{
{\trowd\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx10800\trrh662\row}}}
{\trowd\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx1039\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx2540\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx4041\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx6293\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx7794\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx9295\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx10796\trrh927
\pard\plain\intbl\li22\ri22\sb22\cf1\f51\fs19\qc 1.\plain\intbl\li22\ri22\sa264\cf1\f51\fs16\qc \~\~\~\~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs15\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs15\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs15\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs15\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs15\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs15\ql [\u8230?***\u8230?]\cell{
{\trowd\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx1039\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx2540\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx4041\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx6293\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx7794\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx9295\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx10796\trrh927\row}}}
{\trowd\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx1039\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\clvertalb\cellx2540\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\clvertalb\cellx4041\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\clvertalb\cellx6293\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\clvertalb\cellx7794\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\clvertalb\cellx9295\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx10796\trrh1752
\par\pard\plain\intbl\fs16
\par\pard\plain\intbl\fs16\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\cf1\f52\fs15\ql [\u8230?***\u8230?]\cell{
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{\trowd\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx1039\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx2540\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx4041\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx6293\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx7794\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx9295\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx10796\trrh-66
\pard\plain\intbl\li22\ri22\sb22\cf1\f51\fs19\qc 2.\plain\intbl\li22\ri22\sa264\cf1\f51\fs16\qc \~\~\~\~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs15\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs15\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs15\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs15\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs15\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs15\ql [\u8230?***\u8230?]\cell{
{\trowd\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx1039\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx2540\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx4041\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx6293\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx7794\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx9295\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx10796\trrh-66\row}}}
{\trowd\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx1039\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx2540\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx4041\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx6293\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx7794\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx9295\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx10796\trrh927
\pard\plain\intbl\li22\ri22\sb22\cf1\f51\fs19\qc 3.\plain\intbl\li22\ri22\sa264\cf1\f51\fs16\qc \~\~\~\~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs15\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs15\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs15\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs15\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs15\ql [\u8230?***\u8230?]\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs15\ql [\u8230?***\u8230?]\cell{
{\trowd\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx1039\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx2540\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx4041\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx6293\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx7794\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx9295\clbrdrt\brdrs\brdrcf12\clbrdrl\brdrs\brdrcf12\clbrdrr\brdrs\brdrcf12\clbrdrb\brdrs\brdrcf12\cellx10796\trrh927\row}}}
\par\pard\plain\fs16
\par\pard\plain\fs16
\par\pard\plain\fs16
\par\pard\plain\fs16\pard\plain\cf1\f51\fs16\b\qr ***Confidential Treatment Requested
\par\pard\plain\fs16
\page{\*\bkmkstart doc_1_3}{\*\bkmkend doc_1_3}{\*\bkmkstart s7C50823F3BB094BC2656B45D31A30DD}{\*\bkmkend s7C50823F3BB094BC2656B45D31A30DD}\par\pard\plain\cf1\f51\fs16\b\qr ***Text Omitted and Filed Separately\par\pard\plain\cf1\f51\fs16\b\qr With Securities and Exchange Commission\par\pard\plain\cf1\f51\fs16\b\qr Confidential Treatment Requested\par\pard\plain\cf1\f51\fs16\b\qr Under 17 C.F.R. Section 200.80(b)(4)\par\pard\plain\cf1\f51\fs16\b\qr and 240.24b-2
\par\pard\plain\fs16
\par\pard\plain\fs16
\par\pard\plain
{\trowd\clvertalc\cellx10523\cellx10590\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx10523\cellx10590\trrh-66\row}}}
{\trowd\clvertalc\cellx783\clvertalc\cellx1727\clvertalc\cellx2912\clvertalc\cellx3447\clvertalc\cellx4620\clvertalc\cellx5058\clvertalc\cellx5496\clvertalc\cellx7586\clvertalc\cellx7924\clvertalc\cellx8170\clvertalc\cellx8434\clvertalc\cellx8749\clvertalc\cellx9056\clvertalc\cellx10181\clvertalc\cellx10515\cellx10582\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx783\clvertalc\cellx1727\clvertalc\cellx2912\clvertalc\cellx3447\clvertalc\cellx4620\clvertalc\cellx5058\clvertalc\cellx5496\clvertalc\cellx7586\clvertalc\cellx7924\clvertalc\cellx8170\clvertalc\cellx8434\clvertalc\cellx8749\clvertalc\cellx9056\clvertalc\cellx10181\clvertalc\cellx10515\cellx10582\trrh-66\row}}}
{\trowd\clbrdrt\brdrs\brdrcf1\clbrdrr\brdrs\brdrcf1\clvmgf\cellx5500\clbrdrt\brdrs\brdrcf1\clbrdrr\brdrs\brdrcf1\clvmgf\cellx8175\clbrdrt\brdrs\brdrcf1\cellx10522\cellx10589\trrh216
\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs16\b\ql AMENDMENT OF SOLICITATION/MODIFICATION OF CONTRACT\cell\pard\plain\intbl\li132\ri22\sb22\sa22\fi-154\cf1\f52\fs12\ql 1. CONTRACT ID CODE\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs12\ql \~PAGE OF PAGES\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clbrdrt\brdrs\brdrcf1\clbrdrr\brdrs\brdrcf1\clvmgf\cellx5500\clbrdrt\brdrs\brdrcf1\clbrdrr\brdrs\brdrcf1\clvmgf\cellx8175\clbrdrt\brdrs\brdrcf1\cellx10522\cellx10589\trrh216\row}}}
{\trowd\clbrdrt\brdrs\brdrcf1\clbrdrr\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\clvmrg\cellx5500\clbrdrt\brdrs\brdrcf1\clbrdrr\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\clvmrg\cellx8175\clbrdrr\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\clvertalc\cellx8754\clbrdrb\brdrs\brdrcf1\clvertalc\cellx10186\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10520\clvertalc\cellx10521\clvertalc\cellx10522\clvertalc\cellx10523\clvertalc\cellx10524\clvertalc\cellx10525\cellx10582\trrh248
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sa22\cf1\f51\fs14\qc 1\cell\pard\plain\intbl\li22\sb22\sa22\cf1\f51\fs14\qr 23\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clbrdrt\brdrs\brdrcf1\clbrdrr\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\clvmrg\cellx5500\clbrdrt\brdrs\brdrcf1\clbrdrr\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\clvmrg\cellx8175\clbrdrr\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\clvertalc\cellx8754\clbrdrb\brdrs\brdrcf1\clvertalc\cellx10186\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10520\clvertalc\cellx10521\clvertalc\cellx10522\clvertalc\cellx10523\clvertalc\cellx10524\clvertalc\cellx10525\cellx10582\trrh248\row}}}
{\trowd\clbrdrt\brdrs\brdrcf1\clbrdrr\brdrs\brdrcf1\cellx2914\clbrdrt\brdrs\brdrcf1\cellx4622\clbrdrt\brdrs\brdrcf1\clbrdrl\brdrs\brdrcf1\cellx7927\clbrdrt\brdrs\brdrcf1\clbrdrl\brdrs\brdrcf1\cellx10520\clvertalc\cellx10521\clvertalc\cellx10522\clvertalc\cellx10523\clvertalc\cellx10524\clvertalc\cellx10525\cellx10582\trrh216
\pard\plain\intbl\li22\ri22\sa22\cf1\f52\fs12\ql 2. AMENDMENT/MODIFICATION NO.\cell\pard\plain\intbl\li22\ri22\sa22\cf1\f52\fs12\ql 3. EFFECTIVE DATE\cell\pard\plain\intbl\li22\ri22\sa22\cf1\f52\fs12\ql 4. REQUISITION/PURCHASE REQ. NO.\cell\pard\plain\intbl\li22\ri22\sb22\cf1\f52\fs12\ql \~5. PROJECT NO.\plain\intbl\li22\ri22\sa22\cf1\f52\fs12\i\ql (if applicable)\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clbrdrt\brdrs\brdrcf1\clbrdrr\brdrs\brdrcf1\cellx2914\clbrdrt\brdrs\brdrcf1\cellx4622\clbrdrt\brdrs\brdrcf1\clbrdrl\brdrs\brdrcf1\cellx7927\clbrdrt\brdrs\brdrcf1\clbrdrl\brdrs\brdrcf1\cellx10520\clvertalc\cellx10521\clvertalc\cellx10522\clvertalc\cellx10523\clvertalc\cellx10524\clvertalc\cellx10525\cellx10582\trrh216\row}}}
{\trowd\clbrdrr\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\cellx2914\clbrdrb\brdrs\brdrcf1\cellx4622\clbrdrl\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\cellx7927\clbrdrl\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10520\clvertalc\cellx10521\clvertalc\cellx10522\clvertalc\cellx10523\clvertalc\cellx10524\clvertalc\cellx10525\cellx10582\trrh281
\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs18\ql 29\cell\pard\plain\intbl\li132\ri22\sb22\sa22\cf1\f51\fs18\ql See Block 16C\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs18\ql OS161878\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clbrdrr\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\cellx2914\clbrdrb\brdrs\brdrcf1\cellx4622\clbrdrl\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\cellx7927\clbrdrl\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10520\clvertalc\cellx10521\clvertalc\cellx10522\clvertalc\cellx10523\clvertalc\cellx10524\clvertalc\cellx10525\cellx10582\trrh281\row}}}
{\trowd\cellx1728\cellx2913\clbrdrl\brdrs\brdrcf1\clbrdrr\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\cellx4621\cellx7588\cellx8437\clbrdrl\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\cellx10519\clvertalc\cellx10520\clvertalc\cellx10521\clvertalc\cellx10522\clvertalc\cellx10523\clvertalc\cellx10524\cellx10581\trrh364
\pard\plain\intbl\li22\ri22\sa22\cf1\f52\fs12\ql 6. ISSUED BY\cell\pard\plain\intbl\li22\ri22\sa22\cf1\f52\fs12\qr CODE\cell\pard\plain\intbl\li66\ri22\sb22\sa22\cf1\f51\fs16\ql ASPR-BARDA\cell\pard\plain\intbl\li66\ri22\sb22\cf1\f52\fs12\ql 7. ADMINISTERED BY\plain\intbl\li66\ri22\sa22\cf1\f52\fs12\i\ql (If other than Item 6)
\par\pard\plain\intbl\fs16\cell\pard\plain\intbl\li22\ri22\sa22\cf1\f52\fs12\ql CODE\cell\pard\plain\intbl\li66\ri22\sb22\sa22\cf1\f51\fs16\ql ASPR-BARDA02\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\cellx1728\cellx2913\clbrdrl\brdrs\brdrcf1\clbrdrr\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\cellx4621\cellx7588\cellx8437\clbrdrl\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\cellx10519\clvertalc\cellx10520\clvertalc\cellx10521\clvertalc\cellx10522\clvertalc\cellx10523\clvertalc\cellx10524\cellx10581\trrh364\row}}}
{\trowd\clbrdrr\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\cellx4623\clbrdrb\brdrs\brdrcf1\cellx10522\clvertalc\cellx10523\clvertalc\cellx10524\clvertalc\cellx10525\clvertalc\cellx10526\clvertalc\cellx10527\cellx10584\trrh1190
\pard\plain\intbl\li22\ri22\sb88\sa22\cf1\f51\fs16\ql ASPR-BARDA\par\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs18\ql 200 Independence Ave., S.W.\par\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs18\ql Room 640-G\par\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs18\ql Washington DC 20201
\par\pard\plain\intbl\fs16\cell\pard\plain\intbl\li66\ri22\sb88\sa22\cf1\f51\fs16\ql ASPR-BARDA\par\pard\plain\intbl\li66\ri22\sb22\sa22\cf1\f51\fs18\ql 330 Independence Ave, SW, Rm G640\par\pard\plain\intbl\li66\ri22\sb22\sa22\cf1\f51\fs18\ql Washington DC 20201
\par\pard\plain\intbl\fs16\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clbrdrr\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\cellx4623\clbrdrb\brdrs\brdrcf1\cellx10522\clvertalc\cellx10523\clvertalc\cellx10524\clvertalc\cellx10525\clvertalc\cellx10526\clvertalc\cellx10527\cellx10584\trrh1190\row}}}
{\trowd\cellx4623\clbrdrl\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\cellx5500\clbrdrl\brdrs\brdrcf1\cellx10522\clvertalc\cellx10523\clvertalc\cellx10524\clvertalc\cellx10525\clvertalc\cellx10526\clvertalc\cellx10527\cellx10584\trrh348
\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs12\ql 8. NAME AND ADDRESS OF CONTRACTOR\plain\intbl\li22\ri22\cf1\f52\fs12\i\ql (No., street, county, State and ZIP\plain\intbl\li22\ri22\sa22\cf1\f52\fs12\i\ql Code)\cell\pard\plain\intbl\li22\ri22\sa22\cf1\f51\fs16\qc (x)\cell\pard\plain\intbl\li22\ri22\sa22\cf1\f52\fs12\ql 9A. AMENDMENT OF SOLICITATION NO.\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\cellx4623\clbrdrl\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\cellx5500\clbrdrl\brdrs\brdrcf1\cellx10522\clvertalc\cellx10523\clvertalc\cellx10524\clvertalc\cellx10525\clvertalc\cellx10526\clvertalc\cellx10527\cellx10584\trrh348\row}}}
{\trowd\clvmgf\cellx4623\clbrdrt\brdrs\brdrcf1\clbrdrl\brdrs\brdrcf1\clvertalb\clvmgf\cellx5500\clbrdrl\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10522\clvertalc\cellx10523\clvertalc\cellx10524\clvertalc\cellx10525\clvertalc\cellx10526\clvertalc\cellx10527\cellx10584\trrh281
\par\pard\plain\intbl\fs16\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs16\ql CHIMERIX, INC. 1377270\par\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs16\ql CHIMERIX, INC. 2505 MERIDIAN P\par\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs16\ql 2505 MERIDIAN PKWY STE 340\par\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs16\ql DURHAM NC 277135246\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvmgf\cellx4623\clbrdrt\brdrs\brdrcf1\clbrdrl\brdrs\brdrcf1\clvertalb\clvmgf\cellx5500\clbrdrl\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10522\clvertalc\cellx10523\clvertalc\cellx10524\clvertalc\cellx10525\clvertalc\cellx10526\clvertalc\cellx10527\cellx10584\trrh281\row}}}
{\trowd\clvmrg\cellx4623\clbrdrt\brdrs\brdrcf1\clbrdrl\brdrs\brdrcf1\clvertalb\clvmrg\cellx5500\clbrdrt\brdrs\brdrcf1\clbrdrl\brdrs\brdrcf1\cellx10522\clvertalc\cellx10523\clvertalc\cellx10524\clvertalc\cellx10525\clvertalc\cellx10526\clvertalc\cellx10527\clvertalc\cellx10528\clvertalc\cellx10529\clvertalc\cellx10530\clvertalc\cellx10531\clvertalc\cellx10532\clvertalc\cellx10533\clvertalc\cellx10534\cellx10577\trrh216
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\cf1\f52\fs12\ql \~9B. DATED\plain\intbl\li22\ri22\sa22\cf1\f52\fs12\i\ql (SEE ITEM 11)\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvmrg\cellx4623\clbrdrt\brdrs\brdrcf1\clbrdrl\brdrs\brdrcf1\clvertalb\clvmrg\cellx5500\clbrdrt\brdrs\brdrcf1\clbrdrl\brdrs\brdrcf1\cellx10522\clvertalc\cellx10523\clvertalc\cellx10524\clvertalc\cellx10525\clvertalc\cellx10526\clvertalc\cellx10527\clvertalc\cellx10528\clvertalc\cellx10529\clvertalc\cellx10530\clvertalc\cellx10531\clvertalc\cellx10532\clvertalc\cellx10533\clvertalc\cellx10534\cellx10577\trrh216\row}}}
{\trowd\clvmrg\cellx4623\clbrdrl\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\clvertalb\cellx5500\clbrdrl\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10522\clvertalc\cellx10523\clvertalc\cellx10524\clvertalc\cellx10525\clvertalc\cellx10526\clvertalc\cellx10527\clvertalc\cellx10528\clvertalc\cellx10529\clvertalc\cellx10530\clvertalc\cellx10531\clvertalc\cellx10532\clvertalc\cellx10533\clvertalc\cellx10534\clvertalc\cellx10535\clvertalc\cellx10536\clvertalc\cellx10537\clvertalc\cellx10538\clvertalc\cellx10539\cellx10572\trrh304
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvmrg\cellx4623\clbrdrl\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\clvertalb\cellx5500\clbrdrl\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10522\clvertalc\cellx10523\clvertalc\cellx10524\clvertalc\cellx10525\clvertalc\cellx10526\clvertalc\cellx10527\clvertalc\cellx10528\clvertalc\cellx10529\clvertalc\cellx10530\clvertalc\cellx10531\clvertalc\cellx10532\clvertalc\cellx10533\clvertalc\cellx10534\clvertalc\cellx10535\clvertalc\cellx10536\clvertalc\cellx10537\clvertalc\cellx10538\clvertalc\cellx10539\cellx10572\trrh304\row}}}
{\trowd\clvmrg\cellx4623\clbrdrt\brdrs\brdrcf1\clbrdrl\brdrs\brdrcf1\cellx5500\clbrdrt\brdrs\brdrcf1\clbrdrl\brdrs\brdrcf1\cellx10522\clvertalc\cellx10523\clvertalc\cellx10524\clvertalc\cellx10525\clvertalc\cellx10526\clvertalc\cellx10527\clvertalc\cellx10528\clvertalc\cellx10529\clvertalc\cellx10530\clvertalc\cellx10531\clvertalc\cellx10532\clvertalc\cellx10533\clvertalc\cellx10534\clvertalc\cellx10535\clvertalc\cellx10536\clvertalc\cellx10537\clvertalc\cellx10538\clvertalc\cellx10539\clvertalc\cellx10540\clvertalc\cellx10541\clvertalc\cellx10542\clvertalc\cellx10543\clvertalc\cellx10544\cellx10567\trrh431
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sa22\cf1\f51\fs16\qc x\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs12\ql \~10A. MODIFICATION OF CONTRACT/ORDER NO.\par\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs16\ql \~HHSO100201100013C\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvmrg\cellx4623\clbrdrt\brdrs\brdrcf1\clbrdrl\brdrs\brdrcf1\cellx5500\clbrdrt\brdrs\brdrcf1\clbrdrl\brdrs\brdrcf1\cellx10522\clvertalc\cellx10523\clvertalc\cellx10524\clvertalc\cellx10525\clvertalc\cellx10526\clvertalc\cellx10527\clvertalc\cellx10528\clvertalc\cellx10529\clvertalc\cellx10530\clvertalc\cellx10531\clvertalc\cellx10532\clvertalc\cellx10533\clvertalc\cellx10534\clvertalc\cellx10535\clvertalc\cellx10536\clvertalc\cellx10537\clvertalc\cellx10538\clvertalc\cellx10539\clvertalc\cellx10540\clvertalc\cellx10541\clvertalc\cellx10542\clvertalc\cellx10543\clvertalc\cellx10544\cellx10567\trrh431\row}}}
{\trowd\clvmrg\cellx4623\clbrdrl\brdrs\brdrcf1\clvertalb\clvmgf\cellx5500\clbrdrl\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10522\clvertalc\cellx10523\clvertalc\cellx10524\clvertalc\cellx10525\clvertalc\cellx10526\clvertalc\cellx10527\clvertalc\cellx10528\clvertalc\cellx10529\clvertalc\cellx10530\clvertalc\cellx10531\clvertalc\cellx10532\clvertalc\cellx10533\clvertalc\cellx10534\clvertalc\cellx10535\clvertalc\cellx10536\clvertalc\cellx10537\clvertalc\cellx10538\clvertalc\cellx10539\clvertalc\cellx10540\clvertalc\cellx10541\clvertalc\cellx10542\clvertalc\cellx10543\clvertalc\cellx10544\clvertalc\cellx10545\clvertalc\cellx10546\clvertalc\cellx10547\clvertalc\cellx10548\clvertalc\cellx10549\cellx10562\trrh281
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvmrg\cellx4623\clbrdrl\brdrs\brdrcf1\clvertalb\clvmgf\cellx5500\clbrdrl\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\clvertalb\cellx10522\clvertalc\cellx10523\clvertalc\cellx10524\clvertalc\cellx10525\clvertalc\cellx10526\clvertalc\cellx10527\clvertalc\cellx10528\clvertalc\cellx10529\clvertalc\cellx10530\clvertalc\cellx10531\clvertalc\cellx10532\clvertalc\cellx10533\clvertalc\cellx10534\clvertalc\cellx10535\clvertalc\cellx10536\clvertalc\cellx10537\clvertalc\cellx10538\clvertalc\cellx10539\clvertalc\cellx10540\clvertalc\cellx10541\clvertalc\cellx10542\clvertalc\cellx10543\clvertalc\cellx10544\clvertalc\cellx10545\clvertalc\cellx10546\clvertalc\cellx10547\clvertalc\cellx10548\clvertalc\cellx10549\cellx10562\trrh281\row}}}
{\trowd\clvmrg\cellx4623\clbrdrl\brdrs\brdrcf1\clvertalb\clvmrg\cellx5500\clbrdrt\brdrs\brdrcf1\clbrdrl\brdrs\brdrcf1\clvmgf\cellx10522\clvertalc\cellx10523\clvertalc\cellx10524\clvertalc\cellx10525\clvertalc\cellx10526\clvertalc\cellx10527\clvertalc\cellx10528\clvertalc\cellx10529\clvertalc\cellx10530\clvertalc\cellx10531\clvertalc\cellx10532\clvertalc\cellx10533\clvertalc\cellx10534\clvertalc\cellx10535\clvertalc\cellx10536\clvertalc\cellx10537\clvertalc\cellx10538\clvertalc\cellx10539\clvertalc\cellx10540\clvertalc\cellx10541\clvertalc\cellx10542\clvertalc\cellx10543\clvertalc\cellx10544\clvertalc\cellx10545\clvertalc\cellx10546\clvertalc\cellx10547\clvertalc\cellx10548\clvertalc\cellx10549\clvertalc\cellx10550\clvertalc\cellx10551\clvertalc\cellx10552\clvertalc\cellx10553\clvertalc\cellx10554\clvertalc\cellx10555\clvertalc\cellx10556\trrh-66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\li22\ri22\sb22\cf1\f52\fs12\ql \~10B. DATED\plain\intbl\li22\ri22\sa22\cf1\f52\fs12\i\ql (SEE ITEM 13)\par\pard\plain\intbl\li66\ri22\sb176\sa22\cf1\f51\fs16\ql 02/16/2011\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvmrg\cellx4623\clbrdrl\brdrs\brdrcf1\clvertalb\clvmrg\cellx5500\clbrdrt\brdrs\brdrcf1\clbrdrl\brdrs\brdrcf1\clvmgf\cellx10522\clvertalc\cellx10523\clvertalc\cellx10524\clvertalc\cellx10525\clvertalc\cellx10526\clvertalc\cellx10527\clvertalc\cellx10528\clvertalc\cellx10529\clvertalc\cellx10530\clvertalc\cellx10531\clvertalc\cellx10532\clvertalc\cellx10533\clvertalc\cellx10534\clvertalc\cellx10535\clvertalc\cellx10536\clvertalc\cellx10537\clvertalc\cellx10538\clvertalc\cellx10539\clvertalc\cellx10540\clvertalc\cellx10541\clvertalc\cellx10542\clvertalc\cellx10543\clvertalc\cellx10544\clvertalc\cellx10545\clvertalc\cellx10546\clvertalc\cellx10547\clvertalc\cellx10548\clvertalc\cellx10549\clvertalc\cellx10550\clvertalc\cellx10551\clvertalc\cellx10552\clvertalc\cellx10553\clvertalc\cellx10554\clvertalc\cellx10555\clvertalc\cellx10556\trrh-66\row}}}
{\trowd\clbrdrt\brdrs\brdrcf1\clbrdrr\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\cellx2914\clbrdrt\brdrs\brdrcf1\clbrdrr\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\cellx4622\clbrdrl\brdrs\brdrcf1\clbrdrr\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\clvertalb\cellx5499\clbrdrt\brdrs\brdrcf1\clbrdrl\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\clvmrg\cellx10521\clvertalc\cellx10522\clvertalc\cellx10523\clvertalc\cellx10524\clvertalc\cellx10525\clvertalc\cellx10526\clvertalc\cellx10527\clvertalc\cellx10528\clvertalc\cellx10529\clvertalc\cellx10530\clvertalc\cellx10531\clvertalc\cellx10532\clvertalc\cellx10533\clvertalc\cellx10534\clvertalc\cellx10535\clvertalc\cellx10536\clvertalc\cellx10537\clvertalc\cellx10538\clvertalc\cellx10539\clvertalc\cellx10540\clvertalc\cellx10541\clvertalc\cellx10542\clvertalc\cellx10543\clvertalc\cellx10544\clvertalc\cellx10545\clvertalc\cellx10546\clvertalc\cellx10547\clvertalc\cellx10548\clvertalc\cellx10549\clvertalc\cellx10550\clvertalc\cellx10551\clvertalc\cellx10552\clvertalc\cellx10553\clvertalc\cellx10554\clvertalc\cellx10555\trrh439
\pard\plain\intbl\li22\ri22\sb22\cf1\f52\fs12\ql CODE\plain\intbl\li22\ri22\sa22\cf1\f51\fs12\ql \~\par\pard\plain\intbl\li594\ri22\sb22\sa22\cf1\f51\fs18\ql 1377270\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs12\ql FACILITY CODE\cell\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clbrdrt\brdrs\brdrcf1\clbrdrr\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\cellx2914\clbrdrt\brdrs\brdrcf1\clbrdrr\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\cellx4622\clbrdrl\brdrs\brdrcf1\clbrdrr\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\clvertalb\cellx5499\clbrdrt\brdrs\brdrcf1\clbrdrl\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\clvmrg\cellx10521\clvertalc\cellx10522\clvertalc\cellx10523\clvertalc\cellx10524\clvertalc\cellx10525\clvertalc\cellx10526\clvertalc\cellx10527\clvertalc\cellx10528\clvertalc\cellx10529\clvertalc\cellx10530\clvertalc\cellx10531\clvertalc\cellx10532\clvertalc\cellx10533\clvertalc\cellx10534\clvertalc\cellx10535\clvertalc\cellx10536\clvertalc\cellx10537\clvertalc\cellx10538\clvertalc\cellx10539\clvertalc\cellx10540\clvertalc\cellx10541\clvertalc\cellx10542\clvertalc\cellx10543\clvertalc\cellx10544\clvertalc\cellx10545\clvertalc\cellx10546\clvertalc\cellx10547\clvertalc\cellx10548\clvertalc\cellx10549\clvertalc\cellx10550\clvertalc\cellx10551\clvertalc\cellx10552\clvertalc\cellx10553\clvertalc\cellx10554\clvertalc\cellx10555\trrh439\row}}}
{\trowd\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\cellx10523\clvertalc\cellx10524\clvertalc\cellx10525\clvertalc\cellx10526\clvertalc\cellx10527\clvertalc\cellx10528\clvertalc\cellx10529\clvertalc\cellx10530\clvertalc\cellx10531\clvertalc\cellx10532\clvertalc\cellx10533\clvertalc\cellx10534\clvertalc\cellx10535\clvertalc\cellx10536\clvertalc\cellx10537\clvertalc\cellx10538\clvertalc\cellx10539\clvertalc\cellx10540\clvertalc\cellx10541\clvertalc\cellx10542\clvertalc\cellx10543\clvertalc\cellx10544\clvertalc\cellx10545\clvertalc\cellx10546\clvertalc\cellx10547\clvertalc\cellx10548\clvertalc\cellx10549\clvertalc\cellx10550\clvertalc\cellx10551\clvertalc\cellx10552\clvertalc\cellx10553\clvertalc\cellx10554\clvertalc\cellx10555\clvertalc\cellx10556\clvertalc\cellx10557\trrh195
\pard\plain\intbl\li22\ri22\sa22\cf1\f52\fs13\b\qc 11. THIS ITEM ONLY APPLIES TO AMENDMENTS OF SOLICITATIONS\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\cellx10523\clvertalc\cellx10524\clvertalc\cellx10525\clvertalc\cellx10526\clvertalc\cellx10527\clvertalc\cellx10528\clvertalc\cellx10529\clvertalc\cellx10530\clvertalc\cellx10531\clvertalc\cellx10532\clvertalc\cellx10533\clvertalc\cellx10534\clvertalc\cellx10535\clvertalc\cellx10536\clvertalc\cellx10537\clvertalc\cellx10538\clvertalc\cellx10539\clvertalc\cellx10540\clvertalc\cellx10541\clvertalc\cellx10542\clvertalc\cellx10543\clvertalc\cellx10544\clvertalc\cellx10545\clvertalc\cellx10546\clvertalc\cellx10547\clvertalc\cellx10548\clvertalc\cellx10549\clvertalc\cellx10550\clvertalc\cellx10551\clvertalc\cellx10552\clvertalc\cellx10553\clvertalc\cellx10554\clvertalc\cellx10555\clvertalc\cellx10556\clvertalc\cellx10557\trrh195\row}}}
{\trowd\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\cellx10523\clvertalc\cellx10524\clvertalc\cellx10525\clvertalc\cellx10526\clvertalc\cellx10527\clvertalc\cellx10528\clvertalc\cellx10529\clvertalc\cellx10530\clvertalc\cellx10531\clvertalc\cellx10532\clvertalc\cellx10533\clvertalc\cellx10534\clvertalc\cellx10535\clvertalc\cellx10536\clvertalc\cellx10537\clvertalc\cellx10538\clvertalc\cellx10539\clvertalc\cellx10540\clvertalc\cellx10541\clvertalc\cellx10542\clvertalc\cellx10543\clvertalc\cellx10544\clvertalc\cellx10545\clvertalc\cellx10546\clvertalc\cellx10547\clvertalc\cellx10548\clvertalc\cellx10549\clvertalc\cellx10550\clvertalc\cellx10551\clvertalc\cellx10552\clvertalc\cellx10553\clvertalc\cellx10554\clvertalc\cellx10555\clvertalc\cellx10556\clvertalc\cellx10557\trrh1767
\pard\plain\intbl\li198\ri22\sb22\fi-198\cf1\f54\fs24\ql o\plain\intbl\li198\ri22\cf1\f51\fs13\ql \~\~\~\plain\intbl\li198\ri22\cf1\f52\fs13\ql The above numbered solicitation is amended as set forth in Item 14. The hour and date specified for receipt of Offers\plain\intbl\li198\ri22\cf1\f54\fs24\ql o\plain\intbl\li198\ri22\cf1\f52\fs13\ql \~\~is extended.\plain\intbl\li198\ri22\cf1\f54\fs24\ql o\plain\intbl\li198\ri22\sa22\cf1\f52\fs13\ql \~is not extended\par\pard\plain\intbl\li198\ri22\sb22\cf1\f52\fs13\ql Offers must acknowledge receipt of this amendment prior to the hour and date specified in the solicitation or as amended, by one of the following methods: (a) By\plain\intbl\li198\ri22\cf1\f52\fs13\ql completing Items 8 and 15, and returning ___________ copies of the amendment; (b) By acknowledging receipt of this amendment on each copy of the offer submitted;\plain\intbl\li198\ri22\cf1\f52\fs13\ql or (c) By separate letter or telegram which includes a reference to the solicitation and amendment numbers. FAILURE OF YOUR ACKNOWLEDGEMENT TO BE\plain\intbl\li198\ri22\cf1\f52\fs13\ql RECEIVED AT\plain\intbl\li198\ri22\cf1\f51\fs20\ql \~
\par\pard\plain\intbl\fs16\pard\plain\intbl\li198\ri22\cf1\f52\fs13\ql THE PLACE DESIGNATED FOR THE RECEIPT OF OFFERS PRIOR TO THE HOUR AND DATE SPECIFIED MAY RESULT IN REJECTION OF YOUR OFFER. If by\plain\intbl\li198\ri22\cf1\f51\fs20\ql \~
\par\pard\plain\intbl\fs16\pard\plain\intbl\li198\ri22\cf1\f52\fs13\ql virtue of this amendment you desire to change an offer already submitted, such change may be made by telegram or letter, provided each telegram or letter makes\plain\intbl\li198\ri22\cf1\f51\fs20\ql \~
\par\pard\plain\intbl\fs16\pard\plain\intbl\li198\ri22\sa22\cf1\f52\fs13\ql reference to the solicitation and this amendment, and is received prior to the opening hour and date specified.\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
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{\trowd\clbrdrt\brdrs\brdrcf1\cellx10523\clvertalc\cellx10524\clvertalc\cellx10525\clvertalc\cellx10526\clvertalc\cellx10527\clvertalc\cellx10528\clvertalc\cellx10529\clvertalc\cellx10530\clvertalc\cellx10531\clvertalc\cellx10532\clvertalc\cellx10533\clvertalc\cellx10534\clvertalc\cellx10535\clvertalc\cellx10536\clvertalc\cellx10537\clvertalc\cellx10538\clvertalc\cellx10539\clvertalc\cellx10540\clvertalc\cellx10541\clvertalc\cellx10542\clvertalc\cellx10543\clvertalc\cellx10544\clvertalc\cellx10545\clvertalc\cellx10546\clvertalc\cellx10547\clvertalc\cellx10548\clvertalc\cellx10549\clvertalc\cellx10550\clvertalc\cellx10551\clvertalc\cellx10552\clvertalc\cellx10553\clvertalc\cellx10554\clvertalc\cellx10555\clvertalc\cellx10556\clvertalc\cellx10557\trrh443
\pard\plain\intbl\li22\ri22\sb22\cf1\f52\fs13\ql 12. ACCOUNTING AND APPROPRIATION DATA\plain\intbl\li22\ri22\sa22\cf1\f52\fs13\i\ql (if required)\par\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f51\fs16\ql 2015.1992015.25103 Net Increase: $12,918,174.00\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clbrdrt\brdrs\brdrcf1\cellx10523\clvertalc\cellx10524\clvertalc\cellx10525\clvertalc\cellx10526\clvertalc\cellx10527\clvertalc\cellx10528\clvertalc\cellx10529\clvertalc\cellx10530\clvertalc\cellx10531\clvertalc\cellx10532\clvertalc\cellx10533\clvertalc\cellx10534\clvertalc\cellx10535\clvertalc\cellx10536\clvertalc\cellx10537\clvertalc\cellx10538\clvertalc\cellx10539\clvertalc\cellx10540\clvertalc\cellx10541\clvertalc\cellx10542\clvertalc\cellx10543\clvertalc\cellx10544\clvertalc\cellx10545\clvertalc\cellx10546\clvertalc\cellx10547\clvertalc\cellx10548\clvertalc\cellx10549\clvertalc\cellx10550\clvertalc\cellx10551\clvertalc\cellx10552\clvertalc\cellx10553\clvertalc\cellx10554\clvertalc\cellx10555\clvertalc\cellx10556\clvertalc\cellx10557\trrh443\row}}}
{\trowd\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\cellx10523\clvertalc\cellx10524\clvertalc\cellx10525\clvertalc\cellx10526\clvertalc\cellx10527\clvertalc\cellx10528\clvertalc\cellx10529\clvertalc\cellx10530\clvertalc\cellx10531\clvertalc\cellx10532\clvertalc\cellx10533\clvertalc\cellx10534\clvertalc\cellx10535\clvertalc\cellx10536\clvertalc\cellx10537\clvertalc\cellx10538\clvertalc\cellx10539\clvertalc\cellx10540\clvertalc\cellx10541\clvertalc\cellx10542\clvertalc\cellx10543\clvertalc\cellx10544\clvertalc\cellx10545\clvertalc\cellx10546\clvertalc\cellx10547\clvertalc\cellx10548\clvertalc\cellx10549\clvertalc\cellx10550\clvertalc\cellx10551\clvertalc\cellx10552\clvertalc\cellx10553\clvertalc\cellx10554\clvertalc\cellx10555\clvertalc\cellx10556\clvertalc\cellx10557\trrh825
\pard\plain\intbl\li22\ri22\sa264\cf1\f52\fs13\b\qc 13. THIS ITEM ONLY APPLIES TO MODIFICATION OF CONTRACTS/ORDERS. IT MODIFIES THE CONTRACT/ORDER NO. AS DESCRIBED IN ITEM 14.\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clbrdrt\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\cellx10523\clvertalc\cellx10524\clvertalc\cellx10525\clvertalc\cellx10526\clvertalc\cellx10527\clvertalc\cellx10528\clvertalc\cellx10529\clvertalc\cellx10530\clvertalc\cellx10531\clvertalc\cellx10532\clvertalc\cellx10533\clvertalc\cellx10534\clvertalc\cellx10535\clvertalc\cellx10536\clvertalc\cellx10537\clvertalc\cellx10538\clvertalc\cellx10539\clvertalc\cellx10540\clvertalc\cellx10541\clvertalc\cellx10542\clvertalc\cellx10543\clvertalc\cellx10544\clvertalc\cellx10545\clvertalc\cellx10546\clvertalc\cellx10547\clvertalc\cellx10548\clvertalc\cellx10549\clvertalc\cellx10550\clvertalc\cellx10551\clvertalc\cellx10552\clvertalc\cellx10553\clvertalc\cellx10554\clvertalc\cellx10555\clvertalc\cellx10556\clvertalc\cellx10557\trrh825\row}}}
{\trowd\clbrdrr\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\clvertalb\cellx783\clvmgf\cellx10522\clvertalc\cellx10523\clvertalc\cellx10524\clvertalc\cellx10525\clvertalc\cellx10526\clvertalc\cellx10527\clvertalc\cellx10528\clvertalc\cellx10529\clvertalc\cellx10530\clvertalc\cellx10531\clvertalc\cellx10532\clvertalc\cellx10533\clvertalc\cellx10534\clvertalc\cellx10535\clvertalc\cellx10536\clvertalc\cellx10537\clvertalc\cellx10538\clvertalc\cellx10539\clvertalc\cellx10540\clvertalc\cellx10541\clvertalc\cellx10542\clvertalc\cellx10543\clvertalc\cellx10544\clvertalc\cellx10545\clvertalc\cellx10546\clvertalc\cellx10547\clvertalc\cellx10548\clvertalc\cellx10549\clvertalc\cellx10550\clvertalc\cellx10551\clvertalc\cellx10552\clvertalc\cellx10553\clvertalc\cellx10554\clvertalc\cellx10555\clvertalc\cellx10556\trrh158
\pard\plain\intbl\li22\ri22\sb22\sa22\cf1\f52\fs10\qc CHECK ONE\cell\pard\plain\intbl\li286\ri22\sb22\fi-198\cf1\f52\fs13\ql A. THIS CHANGE ORDER IS ISSUED PURSUANT TO:\plain\intbl\li286\ri22\cf1\f52\fs13\i\ql (Specify authority)\plain\intbl\li286\ri22\cf1\f52\fs13\ql \~\~THE CHANGES SET FORTH IN ITEM 14 ARE MADE IN THE CONTRACT\plain\intbl\li286\ri22\sa22\cf1\f52\fs13\ql ORDER NO. IN ITEM 10A.\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clbrdrr\brdrs\brdrcf1\clbrdrb\brdrs\brdrcf1\clvertalb\cellx783\clvmgf\cellx10522\clvertalc\cellx10523\clvertalc\cellx10524\clvertalc\cellx10525\clvertalc\cellx10526\clvertalc\cellx10527\clvertalc\cellx10528\clvertalc\cellx10529\clvertalc\cellx10530\clvertalc\cellx10531\clvertalc\cellx10532\clvertalc\cellx10533\clvertalc\cellx10534\clvertalc\cellx10535\clvertalc\cellx10536\clvertalc\cellx10537\clvertalc\cellx10538\clvertalc\cellx10539\clvertalc\cellx10540\clvertalc\cellx10541\clvertalc\cel