The HuC6280 has a 64 KB logical address space and a 2 MB physical address space. To access this entire memory space, the HuC6280 uses an MMU (Memory Management Unit) that splits the memory space into segments of 8 KB. The logical address space is split as follows:

Each logical 8 KB segment (or page) is associated with an 8-bit register (MPR0-7) that contains the index of the 8 KB segment (or bank) in physical memory to map in this page. Two special instructions are used to access these registers:

TAMi, transfer the content of the accumulator (A) into an MPR register (0-7).

Waveform playback is the most common and allows a 32 byte, 5 bit unsigned linear sample to be played back at selected frequencies. Frequency modulation takes this one step further, allowing the playback frequency to be dynamically adjusted according to a specified pattern. White noise is used to simulate percussion instruments and effects, such as explosions, by means of a pseudo-random square wave.

Alternatively, each channel can be individually switched to "Direct D/A" mode in which the programmer can send data directly to the sound mixer, allowing more complex sound patterns to be generated, such as speech. Inevitably, this requires more programming effort and CPU time.