SANTA BARBARA, California, February 25, 2014 – Bruker recently sponsored the sixth AFM BioMed International Meeting on AFM in Life Sciences and NanoMedicine. Held last month at the Sanford Consortium for Regenerative Medicine in La Jolla, CA, the conference brought together more than 125 scientists from around the world. The technical...

SANTA BARBARA, California, February 25, 2014 – Bruker recently sponsored the sixth AFM BioMed International Meeting on AFM in Life Sciences and NanoMedicine. Held last month at the Sanford Consortium for Regenerative Medicine in La Jolla, CA, the conference brought together more than 125 scientists from around the world. The technical program featured invited talks from leading bio researchers with over 100 oral and poster presentations on topics ranging from imaging and integrative atomic force microscope (AFM) developments to biomechanics and biomedical applications. Bruker announced the release of BioScope Resolve™, a biological atomic force microscope (bioAFM) that features the highest resolution imaging and most complete cell mechanics capabilities available for use with an inverted optical microscope (IOM). Bruker also hosted two hands-on pre-conference workshops.

“AFM BioMed investigates how atomic force microscopy (AFM) solves relevant biological bottlenecks and provides innovative solutions for healthcare,” explained UC San Diego Associate Professor Adam Engler, AFM BioMed Conference Chair, “The meetings act as a forum to promote innovative cross linked research and highlight the power of integrating AFM with other optical and analytical techniques. This year’s program was a tremendous success, setting a new AFM BioMed record for geographical diversity, with presentations from 20 different countries across 4 continents.”

“I am very pleased to attend AFM BioMed,” added Dr. Martin Pesl, Masaryk University, Czech Republic. “I am from a clinical research background and I realize that AFM has become an emergent tool to cardiologists due to its biomechanical capabilities. I am excited about the new information we can learn through this, for us, new tool.”

In addition to the pre-conference workshops featuring the new BioScope Resolve and the Dimension FastScan-Bio AFMs, Bruker hosted a social event for attendees at the Stone Brewing World Bistro and presented an award for the top poster presentation. This year’s winner was Galja Pletikapić from the Ruđer Bošković Institute. Other poster award winners included Dario Ossola from ETH Zurich in Switzerland, Duckhoe Kim from Columbia University, and Alice Pyne from University College London.

The event provided the perfect venue for the introduction to BioScope Resolve. The new system incorporates Bruker’s proprietary PeakForce Tapping® technology to enable researchers to achieve both the highest resolution imaging and piconewton level force measurements on biological samples. Resolve also provides real-time correlation of atomic force microscopy and optical microscopy data sets to provide unique insights into life sciences research. Ultimately, BioScope Resolve enables imaging and mechanical property mapping of the biological detail of cells, tissues, and biomolecular structures never previously observed with a bioAFM on an IOM.

“After careful evaluation we selected BioScope Resolve due to its highest resolution capability,” said Professor Bin Li of the Shanghai Institute of Applied Physics, China, at the conference. “We believe it will serve our needs well.”

“It was previously impossible to resolve the finest structures of a live cell like microvilli,” added Hermann Schillers from the University of Munster, Germany. “But now with the improved PeakForce Tapping on BioScope Resolve, I can image them easily in one hour…actually it was about 10 minutes.”

The next AFM BioMed meeting will be held in 2016 in Portugal. Visit www.afmbiomed.org for more information on the AFM BioMed Conference.

High-Speed Instruments Combine to Cover Wide Optical Resolution Range

MIDDLETON, Wisconsin, February 10, 2015 – Bruker today announced that the Virginia Tech Carilion Research Institute has purchased both an Opterra Multipoint Scanning Confocal Microscope and a Vutara 350 Super...

MIDDLETON, Wisconsin, February 10, 2015 – Bruker today announced that the Virginia Tech Carilion Research Institute has purchased both an Opterra Multipoint Scanning Confocal Microscope and a Vutara 350 Super Resolution Microscope to further research on cardiac function. The Opterra utilizes a number of innovative features to obtain the speed of wide-field imaging and the resolution of traditional confocal systems while minimizing phototoxicity, making it an ideal solution for gentle and fast confocal imaging of live-cell preparations. The Vutara 350 can break the optical diffraction limit by an order of magnitude, opening up a myriad of research opportunities in single-molecule cellular processes.

“Our primary interests are in studying cardiomyocyte function at both the cellular and molecular level,” explained James W. Smyth. Ph.D., Assistant Professor of Biology at the Center for Heart and Regenerative Medicine Research, Virginia Tech Carilion Research Institute. “It is critical that we are able to perform experiments at both levels on live-cell preparations at the highest data acquisition rate possible. The Bruker Opterra confocal microscope system provides us a microscopy tool for our cellular studies that allows us to optimize speed, signal level and sensitivity to our preparations. The Vutara super-resolution microscope system provides us with a unique tool that will allow us to understand protein interactions at the molecular level in our preparations. Being able to obtain technology from a single manufacturer that allows us to cover such a wide range of applications will be a benefit for us in terms of applications and technical support.”

“Bruker has been investing in fluorescence microscopy for the last two years, first with the acquisition of Prairie Technologies, which formed the nucleus of Bruker Fluorescence Microscopy, and with the more recent acquisition of Vutara,” said Steve Minne, Executive Vice President and General Manager of Bruker's Flourescence Microscopy Business. “Each of our wide range of instruments is differentiated in its application space. Here our video-rate super resolution and low-toxicity, live-cell confocal systems have been combined to create a unique and enabling suite of research capabilities for this group.”

About Virginia Tech Carilion Research Institute The Virginia Tech Carilion School of Medicine and Research Institute leverages Virginia Tech’s world-class strength in basic sciences, bioinformatics, and engineering with Carilion Clinic’s highly experienced medical staff and rich history in medical education. Virginia Tech Carilion improves human health and quality of life by providing leadership in medical education and biomedical and clinical research. For more information, visit research.vtc.vt.edu/heart_center.

About Bruker Bruker Corporation is a leading provider of high-performance scientific instruments and solutions for molecular, cellular and materials research, as well as for industrial, diagnostics, clinical research and applied analysis.