GREMLIN Results:
Residue pairs sorted by strength in covariance:Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

i

j

Raw Score

Scaled Score

50_D

73_H

0.45865

3.575

45_V

77_V

0.30493

2.377

36_L

47_W

0.2644

2.061

49_V

75_L

0.24125

1.881

23_A

27_G

0.22451

1.750

36_L

77_V

0.20638

1.609

47_W

67_P

0.19228

1.499

35_V

64_F

0.19165

1.494

27_G

32_Q

0.18195

1.418

74_T

86_S

0.18014

1.404

48_F

53_P

0.17172

1.339

53_P

78_V

0.16883

1.316

20_A

27_G

0.15784

1.230

34_L

85_A

0.15342

1.196

24_L

32_Q

0.15174

1.183

17_P

20_A

0.1507

1.175

34_L

47_W

0.14497

1.130

39_A

75_L

0.14413

1.124

21_V

32_Q

0.14385

1.121

15_S

22_L

0.14333

1.117

35_V

62_Q

0.14321

1.116

14_T

74_T

0.14086

1.098

23_A

70_P

0.13917

1.085

13_I

38_A

0.13715

1.069

31_R

66_Q

0.13619

1.062

40_G

85_A

0.13612

1.061

14_T

42_R

0.13354

1.041

69_R

73_H

0.13271

1.035

80_A

83_R

0.13263

1.034

17_P

53_P

0.13222

1.031

10_P

41_G

0.13111

1.022

79_D

83_R

0.1304

1.017

48_F

76_T

0.13021

1.015

33_P

86_S

0.12954

1.010

58_Q

63_L

0.1287

1.003

33_P

76_T

0.1274

0.993

17_P

21_V

0.12647

0.986

69_R

72_E

0.12634

0.985

10_P

52_E

0.12429

0.969

51_G

74_T

0.12335

0.962

36_L

65_W

0.1231

0.960

23_A

26_P

0.12248

0.955

46_Y

53_P

0.12177

0.949

23_A

65_W

0.12139

0.946

16_P

54_L

0.12089

0.942

57_T

60_G

0.1185

0.924

22_L

34_L

0.11818

0.921

18_D

36_L

0.118

0.920

47_W

61_H

0.11694

0.912

34_L

75_L

0.1168

0.910

38_A

45_V

0.11675

0.910

10_P

15_S

0.11572

0.902

21_V

26_P

0.11559

0.901

20_A

43_G

0.11464

0.894

57_T

84_S

0.11399

0.889

64_F

73_H

0.11329

0.883

11_L

22_L

0.11318

0.882

53_P

63_L

0.11267

0.878

11_L

82_G

0.1125

0.877

78_V

82_G

0.11149

0.869

19_G

70_P

0.11137

0.868

51_G

72_E

0.11127

0.867

49_V

72_E

0.11111

0.866

14_T

78_V

0.11038

0.860

34_L

67_P

0.10996

0.857

49_V

54_L

0.10996

0.857

50_D

53_P

0.1097

0.855

39_A

57_T

0.10936

0.852

11_L

80_A

0.10926

0.852

43_G

51_G

0.10926

0.852

13_I

18_D

0.10877

0.848

56_T

74_T

0.10868

0.847

11_L

83_R

0.10751

0.838

34_L

77_V

0.10709

0.835

39_A

70_P

0.10706

0.835

31_R

77_V

0.10646

0.830

38_A

41_G

0.10571

0.824

79_D

82_G

0.10535

0.821

47_W

65_W

0.10501

0.819

46_Y

61_H

0.10471

0.816

22_L

35_V

0.10418

0.812

38_A

65_W

0.10355

0.807

33_P

37_K

0.10355

0.807

52_E

56_T

0.10303

0.803

50_D

55_G

0.1029

0.802

52_E

66_Q

0.10218

0.797

26_P

32_Q

0.10208

0.796

55_G

74_T

0.10123

0.789

37_K

80_A

0.10033

0.782

54_L

63_L

0.10022

0.781

18_D

52_E

0.1001

0.780

10_P

70_P

0.10007

0.780

36_L

67_P

0.09994

0.779

19_G

67_P

0.09978

0.778

13_I

16_P

0.09946

0.775

22_L

46_Y

0.09936

0.775

45_V

49_V

0.09908

0.772

11_L

15_S

0.09842

0.767

14_T

37_K

0.0984

0.767

52_E

58_Q

0.09811

0.765

47_W

53_P

0.09803

0.764

22_L

42_R

0.09798

0.764

37_K

66_Q

0.09792

0.763

32_Q

70_P

0.09742

0.759

11_L

53_P

0.09734

0.759

44_P

79_D

0.09682

0.755

25_D

32_Q

0.09661

0.753

10_P

50_D

0.09655

0.753

11_L

78_V

0.09625

0.750

24_L

65_W

0.09612

0.749

Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.

HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits: Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)