Sulfonamides and trimethoprim (a derivative of diaminopyrimidine) block enzymes in two consecutive stages of the biosynthesis of folic acid in a bacterial cell, which leads to suppression of bacterial growth, cessation of their reproduction and death. The combination of active ingredients in the preparation reduces the likelihood of the emergence of resistant forms of pathogenic microflora.

Sulfanilamides are quickly distributed throughout the body, their therapeutic concentration is maintained in serum for 25 hours. Their concentration in kidneys is higher, and in skin, liver and lungs is lower than in blood plasma.

Trimethoprim is rapidly distributed throughout the body, its maximum concentration is reached 4 hours after injection. Concentration in lungs, liver and kidneys is higher than in blood plasma.

Sulfonamides and trimethoprim are excreted by kidneys through glomerular filtration and tubular secretion. A small amount is metabolized in liver and is excreted with bile.

Hypersensitivity to the drug. Do not administer to animals with impaired renal function and liver, ruminant animals with functionally formed proventriculus.

Do not administer to laying hens, eggs of which are used as food.

Administration and dosage

Orally with drinking water or feed in a dose — 0.3-0.35 g of drug per 10 kg of body weight one or two times a day.

For poultry and rabbits the dose is 1 g per 3 l of water, the course of treatment — 4-6 days. Veterinarian, depending on the intensity of the disease and the clinical condition of the animals, may increase the dose of the first administration for 30-50% and extend the course of treatment for 2-3 days.

Animal species

Body weight, kg

Age, week

Daily dose, g

per 100 l of water

per 100 kg of feed

Sucking piglets

under 10

35-50

120-150

Weaned piglets

11-25

25-35

65-80

Breeding pigs

26-100

35-45

80-110

Sows

over 150

–

150-180

Chickens, turkeys, geese, ducks (young poultry)

under 1

13-15

–

1-8

17

34

9-18

25

50

Broiler chickens

1-4

15-18

30-33

5-8

25

42

Warning

Slaughter of calves, sheep, pigs, rabbits for meat is allowed in 4 days, of poultry — in 2 days.

Packaging

Polymer packages of 5, 25 g, 1 kg.

Storage

Store in a dark place, out of children reach at the temperature from +8 °C to +25 °C.

Prepared solution should be used within 1 day. If it’s stored in the fridge — within 3 days.

News

For 25 years BROVAPHARMA company is the leader among manufacturers of veterinary medicinal products in Ukraine. Increasing the volume and range of veterinary products produced in accordance with European standards, BROVAPHARMA confidently looks to
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