Don's say Cock - Instead use: Penis. There are other words, but I don't really use them.

Don't say Cunt - If someone's a bitch, just call her that. But if you're referring to a specific part of the female anatomy, say Vagine (think Borat), Vajayjay, Coochie, Pocketbook (courtesy of my SIL), Monkey (Courtesy of the aforementioned neighbor)

Don't say Pussy - Unless you're talking about a Punk Bitch. If you're talking about coochie, use one of the above words.

Those are the most offensive curse words TO ME. Feel free to tell me what the most offensive curse words to you are in the comments. (57 cool points if you can cuss in a foreign language)