This is Steven Salzberg's blog on genomics, pseudoscience, medical breakthroughs, higher education, and other topics, including skepticism about unscientific medical practices. Here's where I can say what I really think about abuses and distortions of science, wherever I see them.

Pseudoscience continued to thrive in 2011, making my choice for the worst quackery of the year a difficult one. So much nonsense! Promoters of both new age and old-time hocus pocus continued to sell their unscientific therapies, as they have for decades (or centuries), including homeopathy, Ayurveda, acupuncture, qigong, reiki, magnet therapy, and a cornucopia of special "super foods", all guaranteed to cure whatever ails you. These various alternatives to medicine are just as ridiculous today as when they were invented, decades or centuries ago.

How can anyone choose the worst practice among so many false claims? Well, those that cause real harm to patients are worse than those that are merely useless. I also decided to give extra weight to newer forms of mumbo jumbo. But I could have chosen differently, and I encourage readers to nominate their own favorites in the Comments section.

And the 2011 winner of the worst quackery award is: battlefield acupuncture. This particular bizarre medical practice offers a trifecta of ills:

It offers no medical benefit and carries a real risk of harm for some patients.

The U.S. government is wasting tens of millions of dollars per year on it, and plans to increase its spending next year.

The patients are wounded combat veterans who have no choice about where to get treatment.

Battlefield acupuncture has a growing number of supporters in the U.S. Defense Department (especially Richard Niemtzow, its proud inventor), who are determined to see it delivered to as many troops as possible. I've written about this before, but it's in the news again this month, in Wired magazine. In battlefield acupuncture, the "doctor" (no competent doctor would do this) sticks needles into the patient's ear to relieve pain. Yes, that's right: needles in the ear.

Battlefield acupuncture was invented out of whole cloth by military doctor Richard Niemtzow, who runs an acupuncture clinic out of Andrews Air Force Base in Maryland. Niemtzow appears to be the leading advocate for the use of acupuncture on wounded soldiers, and he has been disturbingly effective. The military publication Stars and Stripesreported in August that the Air Force has

"launched a program to train more than 30 military doctors to use acupuncture in the war zone and at their base clinics. The program will be expanded next year with the Air Force, Army and Navy combining funds for two courses to certify 60 active-duty physicians as medical acupuncturists."

Multiple scientific studies have shown clearly that acupuncture doesn't work. The benefit is the same no matter where you place the needles, or even if you use toothpicks that don't pierce the skin. (See a summary here, with multiple references.) Acupuncture points and "meridians" - the pathways that acupuncturists claim to manipulate with their needles - don't even exist.

Acupuncture carries a real risk of harm, too, primarily from infection. Acupuncturists don't practice sterile procedure, as I've pointed out before. They claim that they do, because they think that using sterilized needles is sufficient. Wrong again. Sterile procedure requires that every site of needle insertion be properly sterilized, because most infections are caused by bacteria already present on the skin. As reported last year in BMJ:

"Although most patients recovered, 5-10% died of the infections and at least another 10% had serious consequences such as joint destruction, paraplegia, necrotising fasciitis, and multiorgan failure."

Pretty serious harm from a procedure with no real benefit.

The evidence for "auricular acupuncture" - sticking needles in the ear - is less than zero. This shouldn't be surprising, since Neimtzow just pulled this wacky theory out of thin air - but he and his converts have repeatedly asserted that it works, although they offer nothing more than anecdotes. Niemtzow has even claimed that 18th-century pirates pierced their ears to improve their night vision. Yes, really. Now he's piercing the ears of wounded soldiers.

But the real harm is in treating wounded soldiers by sticking needles in their ears, instead of offering real treatments. To their credit, some soldiers are not fooled by Niemtzow's claims. As a veteran over at Military.com said,

"In civilian medicine, this [battlefield acupuncture] would be called malpractice. This smacks of using military personnel in the field as guinea pigs. That's a dangerous game. If the pain of severe trauma isn't treated effectively in a timely manner, shock and even death can follow."

That discussion appeared in 2008, but three years later, Andrews Air Force Base has a full-time acupuncture clinic, and the military is training more doctors in this dangerous, ineffective, and highly unethical practice. For this, battlefield acupuncture gets my award for the worst quackery of 2011.

Some readers of this blog may be surprised to learn that I'm very optimistic about the future of science and medicine. Over the past few years, I've criticized many different frauds, fakes, bad scientists, bogus claims, quack medical practices, and scam artists. I will continue to do so.

But deep down, I'm an optimist. Science has transformed our lives over the past century, thanks to a list of discoveries far too long to write down, including cures and vaccines for many childhood diseases, better ways to heat and light our homes, and faster ways to travel and communicate. I'm confident science will continue to make progress on all sorts of problems affecting our species. One reason I focus my criticism on pseudoscience is that every minute spent on bad science is a minute that could have been spent on real science, moving us closer to genuine treatments or real scientific discoveries.

But I'm a skeptical optimist. All real scientists must be skeptics: we know that initially exciting results often turn out to be statistical flukes, experimental errors, or just plain randomness. We have to check and double-check our results before publishing, and even then we sometimes make mistakes. Our training makes us skeptical whenever we hear about some amazing new breakthrough, even when we are hopeful that the results are true.

But we can't let pseudoscience take precious resources away from real work. So it's back to the front lines in the ongoing battle against the anti-science forces: watch this space tomorrow for my choice for the worst quackery of 2011.

Here's a choice: save the last remaining tigers on the planet, or kill them, chop them into pieces, and eat them in the mistaken belief that tiger parts can be used as medicine.

Sounds like an easy choice, no? Unfortunately, humans have already decided to kill the tigers rather than saving them. Fewer than 4,000 wild tigers survive on the planet. As journalist Caroline Alexander wrote in a compelling article in the December issue of National Geographic, "tigers in the wild face the black abyss of annihilation." And their greatest threat, she writes, is "the brutal Chinese black market for tiger parts."

Traditional Chinese Medicine (TCM) practitioners claim that tiger parts can be used to treat a wide variety of ailments, including malaria, bacterial infections, bad skin, ulcers, leprosy, and impotence. There is not a whit of scientific evidence to support any of these claims; they are nothing more than folk medicine, based on primitive beliefs dating from a pre-scientific era, when it was believed you could acquire the properties of an animal by eating it. Unfortunately, these beliefs have driven the mightiest of the big cats to the brink of extinction.

Proponents of Traditional Chinese Medicine claim that it is beneficial, but they have no science to back them up. NIH's National Center for Complementary and Alternative Medicine (NCCAM), an apologist for all sorts of quack medical practices, explains that

"In the TCM view, a vital energy or life force called qi circulates in the body through a system of pathways called meridians. Health is an ongoing process of maintaining balance and harmony in the circulation of qi."

This is little more than fantasy. Too bad NCCAM's leaders seem to have forgotten whatever they knew about human physiology. They might just as well explain that midi-chlorians circulating in the blood are the source of the Force. (Actually, there are midichlorians in nature now, in a species of tick. Really.)

Some forms of "alternative medicine" are ineffective but mostly harmless (think homeopathy, which is just water and sugar pills), while others can be harmful to the patients who use them (think acupuncture, with its risk of infection, or ayurveda, which uses toxic chemicals). TCM is doubly harmful: it doesn't benefit patients, and it is the single greatest threat to the world's tigers. I hope people come to their senses before the last tiger is gone.

As the holiday season begins, I decided to discuss some good news about real science.

The promise of stem cell research just got a lot brighter.

There was some very good news from the world of medicine just a couple of weeks ago. For the first time, stem cells were injected into the hearts of humans who had suffered serious heart damage, and patients improved dramatically. It appears that, as everyone hoped, the stem cells grew into new heart cells to replaced the damaged tissue. This is the promise of all stem cell research: to repair or replace damaged organs that otherwise would never recover. In principle, we can someday use the same technique to replace damaged livers, kidneys, spinal cords, cartilege, and virtually all other tissues in the human body.

In the new study, just published in The Lancet, a group of researchers led by Robert Bolli grew stem cells from patients' own hearts, after the patients had suffered serious heart attacks, leaving their hearts permanently damaged. Bolli explained to CNN reporter Caleb Hellerman:

"Once you reach this stage of heart disease, you don't get better. You can go down slowly, or go down quickly, but you're going to go down."

In an effort to repair the patients' hearts, Bolli and colleagues collected a small amount of tissue from each patient's own heart, and purified stem cells from that tissue. By using the patient's own cells, there is no danger of rejection as there would be with cells from an unrelated donor.

They measured the patients' heart function by how much blood was being pumpled through the left ventricle. The patients had an average Left Ventricular Ejection Fraction (LVEF) of 30.3% at the beginning of the study, an indication of very severe heart disease. Four months later, the 16 patients who received the stem cells had an average LVEF of 38.5%, while patients in the control group (who didn't get the stem cells) showed no change. Even more dramatically, after one year the patients LVEF had improved further, to 42.5%.

Thus, remarkably, the cardiac stem cells seem to have "taken" in these patients, growing back into healthy cardiac cells in these severely ill patients. The researchers used MRI to measure the damaged heart tissue in 7 of their patients, and found that it had actually decreased by 30% after one year. In a companion trial at Cedars-Sinai Heart Institute in Los Angeles, Dr. Eduardo Marbán reported similarly positive results. Marbán told CNN that the patients grew approximately 600 million new heart cells after the procedure, comparable to the number of cells that die in a serious heart attack.

One reason these findings are especially dramatic is that they show convincingly that the human heart contains stem cells that can re-grow into new heart cells. It is entirely possible that heart damage that has always been thought to be irreversible can be completely repaired - someday.

The results are very preliminary, and only a few patients have been treated so far, but this is a major triumph for stem cell research. The research in question used adult stem cells, but embryonic stem cells may prove even more effective, and may be easier to obtain because they don't have to come directly from someone's heart.* Heart disease is the leading cause of death in the U.S., and we need to pursue every possibility for new treatments. Those who oppose stem cell research - including embryonic stem cell research - should wake up and take notice: many lives are at stake.

*Disclaimer: Until June 2011, I was a member of the Maryland Stem Cell Research Commission, a state commission established by the legislature and the governor to promote human stem cell research through state-funded grants. The views expressed here, as always, are my own, and do not represent the Commission.