The Meuse is navigable over a substantial part hire hālan lengþe: In Holland and Belgium, the river is part of the major inland navigation infrastructure, connecting the Rotterdam-Amsterdam-Antwerp port areas to the industrial areas upstream: 's Hertogenbosch, Venlo, Maastricht, Liège, Namur. South of Namur, further upstream, the river can only carry more modest vessels, although a barge as long as 100 m. can still reach the French border town of Givet.

From Givet, the river is canalized over a distance of 272 kilometers. The canalized Meuse used to be called the "Canal de l'Est - Branche Nord" but was recently rebaptized into "Canal de la Meuse". The waterway can be used by the smallest barges that are still in use commercially (almost 40 meters long and just over 5 meters wide). Just upstream of the town of Commercy, the Canal de la Meuse connects with the Canal de la Marne au Rhin by means of a short diversion canal. (Source: NoorderSoft Waterways database)