She is probably best known for her recurring role as Jackie Taylor in Beverly Hills, 90210, whom Gillespie played throughout the series' ten year run. Her career on 90210 had her working alongside Michael Durrell, Stanley Kamel, Kerrie Keane, Dina Meyer and Noley Thornton. In 2008, Gillespie reprised her role as Jackie Taylor in an episode of its successor 90210.