Summary: The effect of six-month treatment with
Ukrain on the level of some hormones was investigated in ovariectomized rats.
The serum levels of prolactin, adrenocorticotropic hormone (ACTH), corticosterone,
aldosterone and progesterone were measured by radioimmunoassay (RIA). Six months
after ovariectomy, a decrease in prolactin and progesterone levels was observed.
No changes were noted in the levels of ACTH, corticosterone and aldosterone
in the serum of the ovariectomized animals. On the other hand, six-month treatment
with Ukrain increased the levels of prolactin and progesterone and decreased
the levels of corticosterone and aldosterone in the ovariectomized rats. The
progesterone level in the treated group was four times higher than in the ovariectomized
group. The six-month treatment with Ukrain had no effect on the level of ACTH
of the serum of the ovariectomized rats. The present results show that prolonged
treatment with Ukrain significantly affects hormone secretion after ovariectomy.