Abstract

The aim of this study was to investigate the effect of the Carbopol® hydrogel containing propolis (CHP) on wound healing in a rat model. CHP extracts inhibited nitric oxide production induced by lipopolysaccharide in RAW264.7 cells with a concentration-dependent manner. Wounds were prepared through excision to remove full-thickness skin of rats k]and then were covered with CHP. The covered wounds showed significantly rapid contraction and closure. Histological tissue examination indicated that CHP induced advanced granulation tissue formation and re-epithelialization in the wound. These results indicate that CHP may be helpful for the promotion of wound healing.

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Acknowledgments: This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (NRF-2015R1C1A1A02036746 and 2017M2A2A7A0304183 2).

The image from this article is used as the cover image of the Volume 26, Issue 13.