After pinch hitter Melky Cabrera's two-run single off Brandon Maurer gave the White Sox a 4-3 lead, Frazier tagged up on Tyler Saladino's popped-up bunt while first baseman Wil Myers held the ball in the infield with his back to home plate. When he finally caught on, Myers threw the ball to the backstop.

"It's just one of those things where you kind of read what's going on and you take a chance," Frazier said. "I thought it was a good chance to take. We scored two runs already with our closer coming in."

From San Diego's perspective, the play was emblematic of a comeback that should have been shut down before it happened.

"Those are painful losses," Green said. "Walks and defensive breakdowns. That's one of the ugliest half-innings I've ever seen in baseball; especially at the major league level. There's no excuse for so many things that happened that inning."

The collapse denied Jered Weaver his first win with the Padres after his best outing of the season.

Ryan Buchter (2-2) took the loss, walking three batters while recording only one out. Shortstop Luis Sardinas committed an error on a potential double-play ball that could have made it a scoreless inning for the Padres.

Instead, the White Sox sent 14 batters to the plate. Willy Garcia, Leury Garcia and Yolmer Sanchez each came up with big hits as the White Sox earned their second straight win after a six-game slide.

Weaver (0-4), a three-time All-Star in 11 seasons with the Angels, has struggled since signing with San Diego over the winter. But he pitched six innings of one-run ball against the White Sox.

The right-hander is 12-2 with a 1.87 ERA in 16 career starts against Chicago. His season ERA is now 6.05.

Jose Quintana was working on a shutout for the White Sox before he got into trouble in the seventh. Yangervis Solarte walked, Austin Hedges singled and Hunter Renfroe drove a high fastball just over the right-field fence for a 3-1 lead.

Quintana allowed five hits and walked four in seven innings. Michael Ynoa (1-0) earned the win with a scoreless eighth.