Savino is one of the few upper-tier members of the Barksdale Organization to not be targeted by Omar Little, as he was not actively involved in the murder of Omar's boyfriend Brandon Wright. However, he is soon caught up in the covert investigation into the crew by the Major Case Unit when he is involved in the shooting of Detective Greggs and Orlando.

After the Barksdale crew realizes Orlando is cooperating with the police, Savino meets with Orlando and has him drive, with Greggs in the car posing as a dancer from his club. During the car ride, Savino, suspicious of the presence of Greggs, cleverly turned the volume of the music up in the car so as to hinder any potential listening in from an outside source. Savino stops them at a secluded location and left the car, and enforcers Wee-Bey Brice and Little Man kill Orlando and injure Greggs, not knowing that she was a police officer. (Savino tried to signal them about her presence but they were unable to see him because it was night and very dark out.) Warrants are written up for Savino because he had been identified in the operation, and he turns himself in.

Attorney Maurice Levy makes the argument that Savino was intending to provide Orlando with baking soda instead of cocaine, and that he was unconnected to the shooting, and Savino is expected to receive only a three year sentence. Savino is sentenced to three years for possession of a controlled dangerous substance with intent to distribute it as a CDS in violation of Article 27, section 286B of the Maryland Annotated Code.

Savino involves himself in the Stanfield crew's hunt for Omar after the latter returned, looking for vengeance for the death of Butchie and narrowly escaped an ambush attempt by Chris Partlow, Snoop, O-Dog and Michael Lee.

Savino was shot in the head by Omar Little in retaliation for the torture and murder of Butchie by Chris Partlow and Felicia "Snoop" Pearson. Omar refuses to accept Savino's explanation that he was not present at the incident, reasoning that if Savino had been there he would have joined in with the others.

After Omar's death, the police find his "hit-list" and discover all the upper-tier members of the Stanfield Organization he planned to kill. Savino's name was the only one crossed out, which means he was ultimately the only casualty of Omar's gang war.