In the movie, his character is shown to be doing lines of cocaine, which the actor admits were difficult and weird to shoot. At the premiere, he talks about his experience of shooting the film, saying “I'm sober 24 years now, so dong those hardcore drugs in the movie and we shot it as the sun was coming up, it was like, ‘Wait a minute, this seems vaguely familiar to me—all we need are the birds."

In the upcoming comedy, directed by Jake Kasdan, about a suburban couple played by Cameron Diaz and Jason Segel, who accidentally upload their three-hour sex tape to friends and family members' iPads , Lowe plays Diaz's very conservative prospective employer who also has a naughty side filled with cocaine, booze and more.