BCL6 Protein (Autostainer/Autostainer Plus)

Clone PG-B6p

The BCL6 gene encodes a 706 amino acid nuclear protein of the Kruppel-type zinc finger protein. It is rearranged in about 30% of diffuse large B-cell lymphomas, and is expressed predominantly in normal germinal centre B cells and related lymphomas . The antibody is a useful aid for classification of follicular lymphomas, diffuse large B-cell lymphomas, Burkitt's lymphomas, and nodular, lymphocyte-predominance Hodgkin's lymphoma. The BCL6 antibody, together with BCL2 antibody, is also a useful aid in classification of mantle cell lymphomas, and nodular, lymphocyte-predominance Hodgkin's lymphoma. BCL6 protein is not expressed in B-CLL, hairy cell leukemia, mantle cell and marginal-zone derived lymphomas (1, 2).

The staining performance of all antibodies has been defined, tested and approved through collaboration with leading international pathologists. Check the Atlas of Stains - a guide to diagnostic accuracy.

In Western blotting of total lysates of Bjab cells and BCL6 transfected EB3 cells, or control transfected EB3 cells, the antibody did not label any bands, suggesting lack of reactivity with denatured BCL6 protein (1). SDS-PAGE analysis of immunoprecipitates formed between total lysates of Bjab cells (BCL6+) and BCL6 transfected EB3 cells and the antibody, shows reaction with a ~95 kDa fragment corresponding to BCL6. No reaction is observed with Rd cells (BCL6-) and EB3 cells transfected with a control plasmid (1). See package insert for reference(s).

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