Target

RelevanceThe CD10 antigen (Mw = 100kDa) or "Common Acute Lymphoblastic Leukaemia Antigen" (CALLA) is expressed on the majority of B lymphoid leukaemias. It is also present on a wide variety of normal and neoplastic cell types including renal epithelium, fibroblasts, granulocytes, pre B and pre T cells, and some neural cells and neoplastic cell types including lymphomas and melanomas. It is a cell surface enzyme with endopeptidase activity.
CD19 antigen (MW = 95kDa) is present on 10-15% of human peripheral blood lymphocytes and approximately 60% of splenic lymphocytes. It is not expressed on T lymphocytes, granulocytes, activated T cells or monocytes. Moreover, CD19 is present on principal acute and chronic B cell leukemias and lymphomas.