Causes

Common Causes

Acetaminophen overdose, the reason is usually suicidal intent. Additionally, the toxic threshold dose of acetaminophen decreases in some cases, such as in chronic alcoholics, diabetics, and while fasting. Drug-induced acute liver failure is the most common cause in the developed world. It is responsible for more than 50% of the cases of acute liver failure in the United States.

Viral hepatitis (hepatitis A, B and hepatitis E) are the most common. The incidence of acute liver failure in post-viral hepatitis has decreased due to the vaccination and improved sanitation in the developed world. However, it is still the most common cause in the developing world.