Recent research reports that tenofovir disoproxil fumarate (TDF) therapy for long periods is efficient in Chinese patients with chronic hepatitis B virus (HBV) infection that have relapsed after therapy with multiple nucleoside/nucleotide analogues (NA), such as lamivudine and adefovir, probably due to the development of resistance.

In this prospective study, the researchers evaluated the efficacy and safety of tenofovir disoproxil fumarate (TDF) in 115 chinese chronic hepatitis B (CHB) patients that failed two or more nucleoside/nucleotide analog (NA) therapies. They treated the enrolled patients with TDF 300 mg by oral administration every day for a minimum of 72 weeks. The screening of the hepatitis B virus (HBV) polymerase (P) gene mutation was conducted for each patient. Additionally, virological, biochemical responses and estimated glomerular filtration rate (eGFR) of each patient were evaluated at weeks 12, 24, 48 and 72 of TDF therapy.

Notably, the researchers found that individuals with dual resistance to lamivudine and adefovir had significantly lower complete viral response (CVR), defined as HBV DNA level below 100 IU/mL, rates after 72 weeks than patients resistant to only one of the drugs.

The researchers added in a news release that “TDF monotherapy may not be enough for patients with multiple mutations, which need further antiviral therapies.”

Moreover, the researchers stated that “TDF may serve as a promising agent against HBV infection clinically” given its potent antiviral effects and good tolerability. “Indeed, a randomized double-blind placebo-controlled multicenter clinical trial of the long-term efficacy and safety of TDF therapy in [chronic hepatitis B] patients is warranted to further investigate its application.”

Disclaimer:

Hepatitis News Today is strictly a news and information website about the disease. It does not provide medical advice, diagnosis or treatment. This content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.

Pin It on Pinterest

We use cookies to ensure that we give you the best experience on our website. If you continue to use this site we will assume that you are happy with it. We never use your cookies for creepy ad retargeting that follows you around the web. OkRead more