Guanidine HCl - GMP Denaturant

BIO PHARMA GRADE | GH4220 | CAS# 50-01-1

INTENDED FOR USE IN PHARMACEUTICAL GMP PROCESSES

BIO PHARMA GRADE / GH4220

CAS #: 50-01-1

Molecular Formula:

CH5N3 • HCl

Solubility in Water (g/L): 573

F.W.: 95.53 g/mol

pH @ 20°C: 4.5 - 6.0

Guanidine Hydrochloride is a strong protein denaturant that functions as a chaotropic agent. As a denaturant, it acts to unfold proteins and turn them into their original polypeptide chains. As a chaotropic agent, it breaks down the structure of proteins. Guanidine Hydrochloride is commonly used in the purification of RNA by dissociating the RNA into its nucleic acids and protein forms. At higher concentrations, Guanidine Hydrochloride decreases enzyme activity. It is also used to increase the solubility of hydrophobic molecules.

These are general specifications. BioSpectra will customize our products to meet your quality based requirements.

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General Product Description:

The manufacturing of Bio Pharma Grade GuanidineHydrochloride GH4220 is performed at BioSpectra’sStroudsburg, PA facility and is conducted in a dedicatedprocessing area using only dedicated equipment.• Guanidine HCl is a White Crystalline product.• Molecular Formula: NH2C(NH)NH2HCl.• Molecular Weight: 95.53 g/mol.• CAS Number: 50-01-1.• There are no known major food allergens (as definedby FDA and WHO) in the manufacture of this product.• BioSpectra certifies that all Guanidine HydrochlorideGH4220 at BioSpectra and its raw materials are notderived from or come in contact with animal parts,products, and/or byproducts.• Guanidine Hydrochloride manufactured at BioSpectraand any raw materials used in the manufacture ofGuanidine Hydrochloride at BioSpectra are not subjectto genetic modification.• Synonyms: Guanidine Monohydrochloride, GuanidiniumChloride, Guanidinium Hydrochloride.

GMP Compliance:

Bio Pharma Grade Guanidine Hydrochloride GH4220is manufactured in accordance with GMP guidelinesand is suitable to be used only as the following: IPECCompliant GMP Manufactured Chemical, for use infurther Manufacturing or as a Reagent for Laboratoryand Research. The material represented by this gradeis not intended to be used as an Active PharmaceuticalIngredient, Drug, Drug Product or Household Item.

Expiration/Retest Date:

The recommended retest period for GuanidineHydrochloride is two years from the date of manufacture.