Cholinergic modulation of spontaneous contractions in the pig bladder: The role of the mucosa in the different bladder regions

Abstract

The structural and functional differences between the two main regions of the bladder, the dome and trigone, are well documented. The trigone musculature has been shown to exhibit greater spontaneous activity than the dome (1) and it has been suggested that this may aid contraction of the bladder neck during the storage phase. The mechanisms involved in generation andmodulation of these phasic contractions (PCs) are however still not clear. It has been suggested that they may originate in the mucosal layer and may be modulated by release of transmitters such as acetylcholine from the urothelium.Recent studies have shown structuralheterogeneity of the urothelium and suburothelium between the trigone, dome and lateral body (2) and functionally we have shown differences in the influence of the mucosa on basal SCs developed in isolate strips from these regions of the pig bladder (3)

title = "Cholinergic modulation of spontaneous contractions in the pig bladder: The role of the mucosa in the different bladder regions",

abstract = "The structural and functional differences between the two main regions of the bladder, the dome and trigone, are well documented. The trigone musculature has been shown to exhibit greater spontaneous activity than the dome (1) and it has been suggested that this may aid contraction of the bladder neck during the storage phase. The mechanisms involved in generation andmodulation of these phasic contractions (PCs) are however still not clear. It has been suggested that they may originate in the mucosal layer and may be modulated by release of transmitters such as acetylcholine from the urothelium.Recent studies have shown structuralheterogeneity of the urothelium and suburothelium between the trigone, dome and lateral body (2) and functionally we have shown differences in the influence of the mucosa on basal SCs developed in isolate strips from these regions of the pig bladder (3)",

T1 - Cholinergic modulation of spontaneous contractions in the pig bladder: The role of the mucosa in the different bladder regions

AU - Nyamwaro, Helen

AU - Lawson, Kim

AU - Sellers, Donna J

AU - Chapple, Christopher

AU - McKay, Neil G.

PY - 2011

Y1 - 2011

N2 - The structural and functional differences between the two main regions of the bladder, the dome and trigone, are well documented. The trigone musculature has been shown to exhibit greater spontaneous activity than the dome (1) and it has been suggested that this may aid contraction of the bladder neck during the storage phase. The mechanisms involved in generation andmodulation of these phasic contractions (PCs) are however still not clear. It has been suggested that they may originate in the mucosal layer and may be modulated by release of transmitters such as acetylcholine from the urothelium.Recent studies have shown structuralheterogeneity of the urothelium and suburothelium between the trigone, dome and lateral body (2) and functionally we have shown differences in the influence of the mucosa on basal SCs developed in isolate strips from these regions of the pig bladder (3)

AB - The structural and functional differences between the two main regions of the bladder, the dome and trigone, are well documented. The trigone musculature has been shown to exhibit greater spontaneous activity than the dome (1) and it has been suggested that this may aid contraction of the bladder neck during the storage phase. The mechanisms involved in generation andmodulation of these phasic contractions (PCs) are however still not clear. It has been suggested that they may originate in the mucosal layer and may be modulated by release of transmitters such as acetylcholine from the urothelium.Recent studies have shown structuralheterogeneity of the urothelium and suburothelium between the trigone, dome and lateral body (2) and functionally we have shown differences in the influence of the mucosa on basal SCs developed in isolate strips from these regions of the pig bladder (3)