5. "Men in Black 3"

U.S. opening: May 25Comparables: "Men in Black" (1997) - $250 million, "Men in Black (2002) $190.4 millionPrediction: $210 million
Lowdown: It's been 10 years since Will Smith and Tommy Lee Jones put on their "Men in Black" shades and Smith hasn't appeared on screen in almost four years. That's a lot of time off in both cases, but Hollywood still backed off from challenging Sony when they slotted "Men in Black 3" on the lucrative Memorial Day weekend. With audiences showing little interest in "Battleship" the weekend before antsy moviegoers may flock to the familiar comfort food of Will Smith getting jiggy with it one more time. Considering how the fourth "Mission Impossible" did after a five year break for that franchise ($75 million more domestically) no one is discounting "Men in Black 3's" chances at success. Still, it's one of the biggest question marks of the summer and all of Hollywood will be curious about those daily grosses.