Nitric Oxide

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Nitric oxide is the popular name for AAKG (arginine alpha-ketoglutarate), a compound made from the amino acid L-arginine and alpha-ketoglutarate, a substance formed in the body’s energy-generating process. AAKG is a popular supplement among bodybuilders and other athletes because of claims that it increases production of nitric oxide in muscles. Nitric oxide is known to have blood-flow-enhancing effects,1 which could in theory increase the delivery of oxygen and nutrients to exercising muscle. While L-arginine by itself is known to increase nitric oxide production, no research has been done to show that AAKG does the same. However, double-blind trials of AAKG suggest it improves some measures of strength and power resulting from weight training.2, 3

For an herb, supported by traditional use but minimal or no scientific evidence. For a supplement, little scientific support.

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This supplement has been used in connection with the following health conditions:

Used for

Amount

Why

Athletic Performance

4 gram three times per day

[2 stars]

It has been speculated that AAKG may increase production of nitric oxide, a substance known to enhance blood flow. In one study, AAKG improved measures of strength and short-term power performance in weight lifters.

The information presented in Aisle7 is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. Self-treatment is not recommended for life-threatening conditions that require medical treatment under a doctor's care. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires June 2016.

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