Neils Bohr, one of the founders of Quantum Physics,[1] stated that “deep truths are negated by deep truths.” He meant that scientific paradigms held as incontrovertible truths eventually are negated or superseded by new science that then is itself held as a “deep truth” until a new scientific truth comes along to replace it. In other words, it is best to keep an open mind and view all data, especially strongly held scientific views, as mere approximations to a truth we will continue to pursue for the rest of our lives. So, we do well to maintain an open mind and to question strongly held views, particularly when they don’t seem to be serving us well, such as the pharmaceutical paradigm that reigns in our broken Health Care System.

Emulating our teenagers may not be a bad idea, according to the new science described in the October 2011 cover issue of the National Geographic journal. Even though teenagers may be a challenge to us all, particularly parents, they behave exactly as they should. Their maddening oppositional attitude is exactly what they must do as they prepare to leave the nest and forge a new world for themselves. They must question how their parents’ generation views the world. The wisest of teens will keep the good things they find in their “old foggies” and abandon the ones that they and their peers will not need as they face a fresh new world.

We are entering a time when many old “deep truths” in all walks of life, especially health care, are about to be dethroned.. for our own good. Hugo Rodier, MD

The Brain “Meta-inflamed.”

Industrialization has brought us a much better and easier lifestyle that has prolongued our lifespan. But, as it is with practically all things, we have reached a point of “diminishing returns.” This is the case in both our countries’ economies and in people’s health, which is corroborated by the fact that our children are the first generation documented to have decrease longevity than their parents’.[2] Polluted environments,[3] (especially toxins that have a neuro-endocrine function)[4] refined foods and stress have been well documented to compromise how we metabolize at the cellular level, a key issue in maintaining life and health (see “White Paper” on my website www.hugorodier.com.)

Just as our machines get “hot” when they don’t get optimal fuel and are exposed to challenging environments, our cells get inflamed (and oxidized) in the process of “metabolizing energy,”[5] a problem now referred as “meta-inflammation.”[6]Meta-inflammation occurs in all cells; it seems to be at the root of practically all our chronic health problems, which is why we see an association between meta-inflammation in the lining of arteries (the main conduit of “fuel” or energy delivery to our cells) and the brain of even adolescents and young women.[7] Think of depression as “meta-inflammation” of the brain.[8] Again, it is caused by environmental toxins, stress and, yes processed foods that Americans eat on a regular basis.[9]Of course, we may need to prescribe Prozac to some of these patients; but, most readers may opt for changing the factors that lead to meta-inflammation.

Key to lower Meta-inflammation: optimizing gut function

Eating unprocessed plant-based food, detoxifying well in the gut and heeding our “gut feelings” so that we handle stressful situations better are functions that are inextricably connected; they also have a “common denominator,” the gut. This is why having healthy gut flora goes a long way in controlling meta inflammation, even in the developing brain.[10] Here are more articles highlighting this simple concept:

“Dietary Intake and Risk of Developing Inflammatory Bowel Disease: A Systematic Review of the Literature.”[11] Some patients are told “diet has nothing to do with intestinal inflammation..”

“Enterotypes in gut: different kinds affect people differently.”[13] Each of us are colonized by different gut bacteria; this accounts for different metabolic rates and how we process the food we eat and pharmaceuticals. Each of us has different genetic interactions with the gut flora which in some cases produces more met inflammation.[14]

“Dysbiosis of the faecal microbiota in patients with Crohn’s disease and their unaffected relatives.”[15] Dysbiosis = altered intestinal flora. Relatives of patients with Inflammatory Bowel Disease seem to be affected, too, probably due to sharing the same diet and intimacy.

“Antibiotic Therapy in Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis.”[16] Poor diets, chlorinated water and antibiotics upset the balance of intestinal flora. Correcting it with selected antibiotics helps reduce inflammation in IBS, UC and Chron’s.

Some gut microbes do not recover for 6 months after antibiotics, J. PLoS Biology 2008;6:e280

Meta inflammation will also increase our risk of cancer. Dr. Virchow showed that 150 years ago, a concept that also won the Nobel Prize in Medicine in 1931 (Dr. Warburg.) Think of meta inflammation causing DNA mutations that may lead to cancer. Consequently, plant based foods lower our risk of cancer as reported ad nauseum in this newsletter. Having reviewed this simple fact you may make more sense out of these articles:

“Low Plasma Coenzyme Q10 Levels and Breast Cancer Risk in Chinese Women.”[17] We may supplement CoQ10 and eat more cashews, spinach and sardines.

“Roles of Sildenafil (Viagra) in Enhancing Drug Sensitivity in Cancer.”[21] Even if it does not, you may be getting “pleasant” side effects..”

“Studies Probe Role of Telomere Length in Predicting, Modulating Cancer Risk.”[22] The longer the tale of the chromosome the lower the risk of cancer. And what makes the telomere longer? Antioxidants: they lower meta inflammation of the DNA.

Colon cancer: higher risk when eating red meat (3.5 oz) 5-6 times a week.[23] While this may be true, I suspect that eating organic game does not have the same association. A study showed that eating kangaroo meat did not raise meta inflammation.[24]

Meta inflammation and toxemia of pregnancy

As noted above, meta inflammation is also seen in young women.[25] It also affects blood vessels, which is why some pregnant women, particularly the ones with metabolic issues such as pre diabetes, may develop preeclamsia (high blood pressure, swelling, and clotting.)[26] Now that you know whence meta inflammation, you may understand why these women are at higher risk of cardiovascular disease as they age.

New research is looking into how the environment the fetus is exposed to sets the “thermostat” that will govern baby’s metabolism as an adult. So, mothers who don’t eat good diets may be increasing the risk of metabolic diseases, meta inflammation and obesity[27] in their offspring.[28]

Information on this blog is provided for informational purposes only and is not intended as a substitute for the advice provided by your physician or other healthcare professional. You should not use the information on this blog for diagnosing or treating a health problem or disease, or prescribing any medication or other treatment. These statements have not been evaluated by the Food and Drug Administration. Please consult your health care practitioner with any questions or concerns you may have.