"Enhancer occlusion transcripts regulate the activity of human
enhancer domains via transcriptional interference: a computational
perspective" by Pande et al. has been published by Nucleic Acid
Research

Congratulations Matias for the "Best Poster" award at the X
International Conference on Bioinformatics - Celebrating the 10th
Anniversary of SoIBio and 10th Anniversary of the Master in
Bioinformatics Uruguay.

2019-10-03

"Statins: Complex outcomes but increasingly helpful treatment options for patients"
by Mohammadkhani, Korsching et al. has been published by European Journal of Pharmacology.

Pre-mRNA splicing in eukaryotes is a fundamental step in gene
expression and represents an important level at which the
expression of protein-coding genes can be regulated . In higher
eukaryotes, there are two classes of nuclear pre-mRNA introns. The
most abundant class consists of U2-dependent introns (U2 introns),
whereas the second rarer class (<0.4% of introns) consists of
U12-dependent introns (U12 introns). U12 introns have been found
in the nuclear genomes of vertebrates, plants, and
insects. Introns belonging to these two distinct classes are
spliced by two different spliceosomes: the major U2-type
spliceosome and the less abundant U12-type spliceosome. Although
the first U12 introns to be described had AT-AC terminal
dinucleotides, the majority of U12-type introns contain GT-AG, and
a small number contain other noncanonical terminal
dinucleotides. We use statistical methods to discriminate the two
classes of introns and investigate U12-introns evolutionaty
distribution.