Neighborhood

Groups of genes that are frequently observed in each other's genomic neighborhood.

STRING allows inspection of the interaction evidence for any given network. Choose any of the viewers above (disabled if not applicable in your network).

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:query proteins and first shell of interactors

white nodes:second shell of interactors

Node Content

empty nodes:proteins of unknown 3D structure

filled nodes:some 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

EDP06643

CCAAT-binding transcription factor subunit A (107 aa)

Predicted Functional Partners:

EDP02987

Hypothetical transcription factor Hap5a-like protein (85 aa)

0.992

EDP05135

SNF2 superfamily protein (1610 aa)

0.868

SET4

Histone methyltransferase (2983 aa)

0.846

EDP09315

High mobility group protein (552 aa)

0.845

EDP03175

Histone methyltransferase (1708 aa)

0.838

EDP06201

Predicted protein (211 aa)

0.736

HTB2

Histone H2B; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (156 aa)

0.726

HTB14

Histone H2B; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (153 aa)

0.726

HTB4

Histone H2B; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (153 aa)

a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1

node2

node1 accession

node2 accession

node1 annotation

node2 annotation

score

EDP02987

EDP06643

EDP02987

EDP06643

Hypothetical transcription factor Hap5a-like protein

CCAAT-binding transcription factor subunit A

0.992

EDP03175

EDP05135

EDP03175

EDP05135

Histone methyltransferase

SNF2 superfamily protein

0.962

EDP03175

EDP06643

EDP03175

EDP06643

Histone methyltransferase

CCAAT-binding transcription factor subunit A

0.838

EDP03175

EDP08515

EDP03175

EDP08515

Histone methyltransferase

Histone H2B

0.661

EDP03175

EDP09315

EDP03175

EDP09315

Histone methyltransferase

High mobility group protein

0.893

EDP03175

HTB14

EDP03175

EDP08533

Histone methyltransferase

Histone H2B; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling

0.661

EDP03175

HTB2

EDP03175

EDP08976

Histone methyltransferase

Histone H2B; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling

0.661

EDP03175

HTB4

EDP03175

EDP08526

Histone methyltransferase

Histone H2B; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling

0.661

EDP03175

SET4

EDP03175

EDO96754

Histone methyltransferase

Histone methyltransferase

0.837

EDP05135

EDP03175

EDP05135

EDP03175

SNF2 superfamily protein

Histone methyltransferase

0.962

EDP05135

EDP06643

EDP05135

EDP06643

SNF2 superfamily protein

CCAAT-binding transcription factor subunit A

0.868

EDP05135

EDP08515

EDP05135

EDP08515

SNF2 superfamily protein

Histone H2B

0.825

EDP05135

EDP09315

EDP05135

EDP09315

SNF2 superfamily protein

High mobility group protein

0.965

EDP05135

HTB14

EDP05135

EDP08533

SNF2 superfamily protein

Histone H2B; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling

0.825

EDP05135

HTB2

EDP05135

EDP08976

SNF2 superfamily protein

Histone H2B; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling

0.825

EDP05135

HTB4

EDP05135

EDP08526

SNF2 superfamily protein

Histone H2B; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling

0.825

EDP05135

SET4

EDP05135

EDO96754

SNF2 superfamily protein

Histone methyltransferase

0.965

EDP06201

EDP06643

EDP06201

EDP06643

Predicted protein

CCAAT-binding transcription factor subunit A

0.736

EDP06643

EDP02987

EDP06643

EDP02987

CCAAT-binding transcription factor subunit A

Hypothetical transcription factor Hap5a-like protein

0.992

EDP06643

EDP03175

EDP06643

EDP03175

CCAAT-binding transcription factor subunit A

Histone methyltransferase

0.838

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Network Stats

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Functional enrichments in your networkNote: some enrichments may be expected here (why?)

Enrichment analysis is still ongoing, please wait ...

Statistical background

For the above enrichment analysis, the following statistical background is assumed: