Bottom Line:
Good correlation was found between the Abbot vs.This relationship between levels of HBsAg and HBV DNA seemed to depend on genotypes.While HBsAg quantitation is not affected by HBV genotype, the observed association between levels of HBsAg and HBV DNA seems genotype dependent.

Background: The decline in hepatitis B virus surface antigen (HBsAg) may be an early predictor of the viral efficacy of Hepatitis B virus (HBV) therapy. The HBsAg levels obtained by different immunoassays now need comparing and the relationships between levels of HBsAg and HBV DNA alongside HBsAg and genotype must be evaluated.

Conclusion/significance: The quantitation of HBsAg in routine clinical samples is comparable between the reference assay and the adapted assays with acceptable accuracy limits, low levels of variability and minimum discrepancy. While HBsAg quantitation is not affected by HBV genotype, the observed association between levels of HBsAg and HBV DNA seems genotype dependent.

Mentions:
Overall, levels of HBsAg and HBV DNA were weakly correlated, whatever the HBsAg assay used (Fig. 2). Taking into account the HBeAg status (+/−), the correlations between HBsAg and HBV DNA levels remained weak, with an identical correlation for HBeAg-negative patients and HBeAg positive patients of 0.33 using the Abbott assay (data not shown).

Mentions:
Overall, levels of HBsAg and HBV DNA were weakly correlated, whatever the HBsAg assay used (Fig. 2). Taking into account the HBeAg status (+/−), the correlations between HBsAg and HBV DNA levels remained weak, with an identical correlation for HBeAg-negative patients and HBeAg positive patients of 0.33 using the Abbott assay (data not shown).

Bottom Line:
Good correlation was found between the Abbot vs.This relationship between levels of HBsAg and HBV DNA seemed to depend on genotypes.While HBsAg quantitation is not affected by HBV genotype, the observed association between levels of HBsAg and HBV DNA seems genotype dependent.

Background: The decline in hepatitis B virus surface antigen (HBsAg) may be an early predictor of the viral efficacy of Hepatitis B virus (HBV) therapy. The HBsAg levels obtained by different immunoassays now need comparing and the relationships between levels of HBsAg and HBV DNA alongside HBsAg and genotype must be evaluated.

Conclusion/significance: The quantitation of HBsAg in routine clinical samples is comparable between the reference assay and the adapted assays with acceptable accuracy limits, low levels of variability and minimum discrepancy. While HBsAg quantitation is not affected by HBV genotype, the observed association between levels of HBsAg and HBV DNA seems genotype dependent.