Proceeding from natural amino acid L-asparagine
and commercially available aldehydes a stereoselective synthesis was developed
of (2S,4S)-2-alkyl(aryl)-3-(3-sulfanylpropanoyl)-6-oxohexahy- dropyrimidine-4-carboxylic
acids, potential antihypertensive drugs, inhibitors of the angiotensin converting
enzyme.