Cruel Intentions actress Selma Blair has apologised for the bizarre mid-air outburst which led to her being hospitalised after a flight from Cancun to Los Angeles.

The 43-year-old, who was taken off the plane on a stretcher, explained her actions in a statement to Vanity Fair.

"I made a big mistake yesterday. After a lovely trip with my son and his Dad, I mixed alcohol with medication, and that caused me to black out and led me to say and do things that I deeply regret," Selma said.

"My son [five-year-old Arthur] was with his Dad asleep with his headphones on, so there is that saving grace. I take this very seriously, and I apologise to all of the passengers and crew that I disturbed and am thankful to all of the people who helped me in the aftermath.

"I am a flawed human being who makes mistakes and am filled with shame over this incident. I am truly very sorry.

Eyewitnesses told TMZ they saw Selma in first class drinking wine and putting something in the glass, before disrupting everyone with incoherent shouting.