Highlights The mode of HIV-1 spread determines the outcome form of cell death Cell-to-cell spread is required to deplete non-permissive CD4 T cells via pyroptosis Free HIV-1 particles, even in large quantities, are unable to trigger pyroptosis The fundamental “killing units” of CD4 T cells are infected cells, not the virus Summary The progressive depletion of CD4…

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Supported by the National Institute Of Allergy And Infectious Diseases of the National Institutes of Health under Award Number U19AI096109. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

About NAPWHA

Founded in 1989, The National Association of People with HIV Australia (NAPWHA) is Australia’s peak non-government organisation representing community-based groups of people living with HIV (PLHIV).