MCMASTER UNIVERSITY

MCMASTER UNIVERSITY Patent applications

Patent application number

Title

Published

20160106820

VACCINE COMPOSITION - There is described a kit for use in inducing an immune response in a mammal, the kit includes: a first virus that expresses MAGEA3, Human Papilloma Virus E6/E7 fusion protein, human Six-Transmembrane Epithelial Antigen of the Prostate protein, or Cancer Testis Antigen 1, or a variant thereof as an antigenic protein and that is formulated to generate an immunity to the protein or variant thereof in the mammal. The kit also includes a Maraba MG1 virus encoding the same antigen, or a variant of the same antigen. The Maraba MG1 virus is formulated to induce the immune response in the mammal. The first virus is immunologically distinct from the Maraba MG1 virus.

04-21-2016

20160102453

SELF-REINFORCED MASONRY BLOCKS, WALLS MADE FROM SELF-REINFORCED MASONRY BLOCKS, AND METHOD FOR MAKING SELF-REINFORCED MASONRY BLOCKS - A self-reinforced masonry block comprises a main body having opposed substantially parallel stacking surfaces and at least one tubular cell defined therethrough from one stacking surface to the other. At least one confining reinforcement is embedded in the main body to surrounding a corresponding cell. Each confining reinforcement extends substantially entirely along the longitudinal length of its corresponding cell and terminates inwardly of the stacking surfaces. The self-reinforced masonry blocks may be used in construction of a grout-filled, vertically reinforced masonry block wall, with the self-reinforced masonry blocks being used for those portions of the wall where the grouted cells are prone to crushing due to high levels of compressive stress, and conventional unreinforced masonry blocks being used for other portions of the wall. A method for making the self-reinforced masonry blocks is also described.

04-14-2016

20160054310

BIOSENSORS UTILIZING INK JET-PRINTED BIOMOLECULE COMPATIBLE SOL GEL INKS AND USES THEREOF - Novel solid-phase biosensors that utilize ink jet printing of biocompatible sol-gel based inks to create sensor strips are reported herein. Biomolecules and other reagents useful in bioassays to detect, for example, pathogenic microorganisms or toxic substances, are immobilized on a substrate, which can be paper based, by layering these substances between two layers of biomolecule compatible sol gel. The sol gel precursor solutions and solutions of the assay reagents are printed from separate nozzles in a layered approach which avoids clogging of the nozzles by the pre-mature gelling of the sol gel precursor solution. In certain embodiments of the application, a capture agent is used to concentrate a compound to be detected in specific areas on the substrate to facilitate detection.

02-25-2016

20160047826

COMPOSITIONS AND METHODS FOR DETECTION OF A TARGET IN A MOLECULAR ASSAY USING PH CHANGES - The disclosure provides a sensor for detecting a target comprising a probe that is able to recognize the presence of the target; a pH-changing enzyme conjugated to an oligonucleotide that senses the recognition of the presence of the target by the probe; and a solid support linked or linkable to the probe; wherein the presence of the target causes the sensor to be either captured to the solid support or released into solution for detection of pH changes. Also provided are methods for using the sensor and kits.

02-18-2016

20160047773

SENSORS AND METHODS FOR DETECTINGAN OXIDANT - The present application relates to sensors and methods for detecting and/or quantifying an oxidant such as free chlorine in a liquid sample such as drinking water. The sensors comprise a first electrode, a second electrode and a composite material between and connecting the first electrode and the second electrode, the composite material comprising a semiconductor and a redox-switchable organic compound associated therewith. The methods comprise exposing the liquid sample to the sensor under conditions to oxide the redox-switchable organic compound and analyzing a resulting change in current.

02-18-2016

20160036366

TORQUE RIPPLE AND RADIAL FORCE REDUCTION IN DOUBLE-ROTOR SWITCHED RELUCTANCE MACHINES - A double-rotor switched reluctance machine includes a stator, a first rotor, and a second rotor. The stator and the first rotor operate as a first electric machine and the stator and the second rotor operate as a second electric machine. Each electric machine has an output torque profile that fluctuates periodically between a maximum and a minimum instantaneous torque. The double-rotor switched reluctance machine is configured so that when the first and second electric machines are operated at a common electrical frequency, the first and second maximum instantaneous torques are temporally offset, thereby reducing the overall torque ripple of the switched reluctance machine. Additionally, or alternatively, a double-rotor switched reluctance machine is configured so that the first and second rotors are radially offset from each other to reduce a net radial force imposed on the stator by the operation of the first and second electric machines.

02-04-2016

20150368367

SURFACE MODIFICATION OF CELLULOSE NANOCRYSTALS - Hydrophobic CNCs were successfully prepared by grafting amine- and thiol terminated hydrocarbons to CNCs that have been previously coated with plant polyphenols. Hydrocarbons of various chain lengths can be used to tune the hydrophobicity of the modified CNCs. After the surface modification process, CNCs can be easily redispersed in nonpolar solvents highlighting the potential of the hydrophobic CNCs in, for example, CNC reinforced nanocomposites and non-aqueous formulations.

12-24-2015

20150354024

METHODS FOR BINDING AND PRECIPITATING GOLD USING MICROBIAL-DERIVED METALLOPHORES AND THEIR USES - The present application discloses metallophores that complex soluble gold and generate solid gold forms, including gold nanoparticles. In an embodiment, the metallophores are microbial metabolites isolated from organisms that are resistant to gold, or are analogs thereof. Methods of using the metallophores to extract and detect gold, along with detectors comprising the metallophores are disclosed.

12-10-2015

20150263190

INTEGRATED THERMAL STABILIZATION OF A MICRORING RESONATR - Embodiments of the present disclosure provide devices and methods involving the thermal stabilization of microring resonators, such as microring modulators. Power is measured via an on-chip photodetector integrated with a drop port of the microring resonator, providing a local measurement of average power. This average power is employed as a feedback measure to actively control a heater that is integrated with the microring resonator, in order to stabilize the resonant wavelength of the microring resonator in the presence of thermal fluctuations. Employing such a system, a microring modulator can maintain error-free performance under thermal fluctuations that would normally render it inoperable.

09-17-2015

20150148242

SCREENING METHOD AND SYSTEMS UTILIZING MASS SPECTRAL FRAGMENTATION PATTERNS - The present application is directed to methods and systems for identifying small molecule compounds in mixtures using a library comprising calculated structures and corresponding calculated mass spectral fragmentation patterns of known and/or hypothetical small molecule compounds that may be in the mixture and screening of a mass spectrum of the mixture using the library to identify matching fragmentation patterns. If a mass spectral fragmentation pattern present in the mass spectrum of the mixture matches a calculated fragmentation pattern of one of the known or hypothetical compounds this confirms the identity of a compound in the mixture as the known or hypothetical compound. The method represents a platform method that can be used for a multitude of purposes related to the screening and identification of compounds in mixtures. Therefore the methods and systems of the present application represent an approach that is uniquely capable of navigating chemical space and providing a understanding of desired families and pharmacophores.

IMMUNOCOMPATIBLE POLYMERS - A polymer matrix is provided comprising an amine-containing polyampholyte covalently crosslinked with an electrophilic polymer to yield an immunocompatible polymer matrix. A hydrogel system incorporating the polymer matrix is also provided.

10-16-2014

20140249233

METHOD FOR ENHANCING FOLDING AND TRANSPORT OF MISFOLDED GLUCOCEREBROSIDASE - Therapeutic compositions and methods for treatment of late-onset Gaucher disease are described herein. The compositions comprise compounds having activity as pharmacological chaperones for mutant forms of the beta-glucocerebrosidase. Methods of treatment involve providing therapeutically effective amounts of such compositions to subjects in need thereof.

METHOD OF TREATING LYSOSOMAL STORAGE DISORDERS - Therapeutic compositions and methods for treatment of late-onset Gaucher disease are described herein. The compositions comprise compounds having activity as pharmacological chaperones for mutant forms of the beta-glucocerebrosidase. Methods of treatment involve providing therapeutically effective amounts of such compositions to subjects in need thereof.

08-21-2014

20140159529

SWITCHED RELUCTANCE MACHINE WITH ROTOR EXCITATION USING PERMANENT MAGNETS - Various embodiments are described herein for a switched reluctance machine having a rotor excitation. In one example embodiment, the switched reluctance machine comprises a stator and a rotor. The rotor may be disposed inside or outside the stator. The rotor is spaced from the stator, and the rotor and the stator are concentrically disposed. The rotor has a plurality of rotor poles having an excitation source, where the excitation source comprises at least one adjustable parameter. The excitation source is provided by a permanent magnet. The dimensions and various other parameters associated with the permanent magnets are adjustable.

DOUBLE-ROTOR SWITCHED RELUCTANCE MACHINE - Various embodiments are described herein for a double-rotor switched reluctance machine. In one example embodiment, the double-rotor switched reluctance machine comprises an interior rotor, an exterior rotor spaced from the interior rotor and coaxially and concentrically disposed outside the interior rotor, and at least one stator disposed concentrically with the interior rotor and the exterior rotor. The interior rotor, the exterior rotor and the at least one stator are disposed within one machine set to provide an interior switched reluctance machine and an exterior switched reluctance machine. The interior switched reluctance machine and the exterior switched reluctance machine can operate as two motors, two generators, or a motor and a generator simultaneously.

04-24-2014

20140065070

METHODS OF PREPARING TRIAZOLE-CONTAINING RADIOIODINATED COMPOUNDS - The present application relates to methods of preparing radiohalogenated compounds, to compounds useful in such methods and to radiohalogenated compounds useful for imaging and/or therapy. In particular, the present application relates to methods of preparing radiohalogenated compounds of Formula I, to compounds useful in such methods and to radiohalogenated compounds of Formula I:

03-06-2014

20140055621

OPTIMAL CAMERA SELECTION IN ARRAY OF MONITORING CAMERAS - Technologies are generally described for automatically optimizing an efficiency of camera placement, numbers, and resolution in multi-camera monitoring and surveillance applications. In some examples, a fraction of a total area may be monitored at a higher resolution than the rest. Employing techniques such as combinatorial state Viterbi technique or combinatorial state trellis technique, a minimum number of cameras that provide the coverage at the needed resolution may be selected. Similarly, a number of points may be covered with at least a predefined number of cameras. For example, a subject of interest may be tracked in a public area, where specific camera(s) may be used to image the subject's face at a higher resolution than the background.

02-27-2014

20140031168

ELECTRO-MECHANICAL DOUBLE-ROTOR COMPOUND HYBRID TRANSMISSION - A hybrid vehicle transmission including a double-rotor electric machine, two planetary gear sets, an input shaft, and an output shaft, where the input shaft, the output shaft, and a first rotor of the double-rotor electric machine are each coupled to a member of the first planetary gear set, the output shaft and a second rotor of the double-rotor electric machine are each coupled to a member of the second planetary gear set, and a member of the second planetary gear set not coupled to the output shaft or the second rotor is selectively coupled to the first rotor via a first torque transfer device, and selectively coupled to a transmission housing via a second torque transfer device.

Treatment of Cancer WIth Dopamine Receptor Antagonists - Described are methods of treating a cancer comprising administering to a subject in need thereof an effective amount of a dopamine receptor (DR) antagonist. The DR antagonist may be a phenothiazine derivative, such as thioridazine or chlorpromazine. Optionally, the cancer is acute myeloid leukemia. Also described are methods for identifying subjects with cancer, methods for providing a prognosis for a subjects with cancer and/or subjects likely to be responsive to therapy with DR receptor antagonists. Methods for identifying cancer stem cells and chemotherapeutic compounds that are DR receptor antagonists as also provided.

12-12-2013

20130330754

SOL-GEL DERIVED SENSOR FOR RAPID DETERMINATION OF HEAVY METALS - The present application is directed to a novel approach for rapid, selective and sensitive detection of heavy metals using a solid-phase bioactive lab-on-paper sensor that is ink-jet printed with sol-gel entrapped reagents to allow colorimetric visualization of the enzymatic activity. The bioactive paper assay is able to detect a range of heavy metals, either alone or as mixtures, in as little as 10 min. The paper-based assay was immune to interferences from non-toxic metal ions such as Na

12-12-2013

20130296883

AUTOMATED DETECTION, DIAGNOSTIC AND THERAPEUTIC METHOD AND SYSTEM - A medical insertion device which may be used with or installed within an imaging system, such as magnetic resonance imaging (MRI). The medical insertion device can generally be used to retain, position and effect insertion of a medical instrument, for example a biopsy device or an ablation treatment device. The device can generally provide linear and/or angular degrees of freedom for positioning of the medical instrument prior to an insertion of the medical instrument. The medical insertion device includes a mounting arm, an interface connected to the mounting arm for interfacing with a medical instrument, a mechanism for movement of the medical instrument or a part of the medical instrument in an insertion direction, a carriage connected to a distal end of the mounting arm, and a pivot connection between the carriage and the distal end of the mounting arm to permit pitch or yaw of the mounting arm.

11-07-2013

20130287705

METHOD OF TREATING MUCOSAL INFLAMMATION - A method of treating mucosal inflammation associated with a pathological condition in a mammal is provided. The method comprises the step of inhibiting 5-HT signaling at a target site in order to block 5-HT7 receptor function.

10-31-2013

20130252987

METHOD OF REGULATING PLASMA LIPOPROTEINS - A method of modulating the level of lipoproteins in human cells comprising the step of inhibiting resistin in the cells or cellular environment. The method is useful to treat cardiovascular disease.

09-26-2013

20130252783

POWERTRAIN SYSTEM FOR HYBRID VEHICLES HAVING COMPOUND AND SPLIT MODES OF OPERATION - A powertrain system for a vehicle is provided, including an internal combustion engine, a drivetrain gear for connection to a drivetrain of the vehicle, a gearset connecting the internal combustion engine to the drivetrain gear, a first electric machine connected to the gearset, a second electric machine, and at least one dynamic clutch selectively coupling the second electric machine to the drivetrain gear and the gearset. In a compound mode of operation, the at least one dynamic clutch couples the second electric machine and the gearset. In a split mode of operation, the at least one dynamic clutch couples the second electric machine and the drivetrain gear.

09-26-2013

20130252774

INTEGRATED ELECTRO-MECHANICAL POWERTRAIN SYSTEM FOR HYBRID VEHICLES - A vehicle powertrain system including a differential gear set, a planetary gear set coupled to the differential gear set, an engine coupled to the planetary gear set to transfer power between the engine and the planetary gear set, a first electric machine coupled to the planetary gear set via a first clutch and selectively engagable, via actuation of the first clutch, to transfer power between the first electric machine and the planetary gear set, and a second electric machine coupled to the planetary gear set via a second clutch and selectively engagable, via actuation of the second clutch, to transfer power between the second electric machine and the planetary gear set.

09-26-2013

20130252773

POWERTRAIN SYSTEM FOR HYBRID VEHICLES HAVING MULTIPLE MODES OF OPERATION - A powertrain system for a vehicle is provided. The powertrain system includes an internal combustion engine, a first gearset connected to the internal combustion engine, a first electric machine connected to the first gearset, a drivetrain gear for connection to a drivetrain of the vehicle, a second gearset connecting the first gearset to the drivetrain gear, a second electric machine, and at least one dynamic clutch selectively coupling the second electric machine to the first electric machine, the first gearset, and the second gearset. In a first mode of operation, the at least one dynamic clutch couples the second electric machine and the first electric machine. In a second mode of operation, the at least one dynamic clutch couples the second electric machine and the first gearset. In a third mode of operation, the at least one dynamic clutch couples the second electric machine and the second gearset.

09-26-2013

20130247497

SELF-REINFORCED MASONRY BLOCKS, WALLS MADE FROM SELF-REINFORCED MASONRY BLOCKS, AND METHOD FOR MAKING SELF-REINFORCED MASONRY BLOCKS - A self-reinforced masonry block comprises a main body having opposed substantially parallel stacking surfaces and at least one tubular cell defined therethrough from one stacking surface to the other. At least one confining reinforcement is embedded in the main body to surrounding a corresponding cell. Each confining reinforcement extends substantially entirely along the longitudinal length of its corresponding cell and terminates inwardly of the stacking surfaces. The self-reinforced masonry blocks may be used in construction of a grout-filled, vertically reinforced masonry block wall, with the self-reinforced masonry blocks being used for those portions of the wall where the grouted cells are prone to crushing due to high levels of compressive stress, and conventional unreinforced masonry blocks being used for other portions of the wall. A method for making the self-reinforced masonry blocks is also described.

09-26-2013

20130184352

METHOD OF TREATING GAUCHER DISEASE - Therapeutic compositions and methods for treatment of late-onset Gaucher disease are described herein. The compositions comprise compounds having activity as pharmacological chaperones for mutant forms of the beta-glucocerebrosidase. Methods of treatment involve providing therapeutically effective amounts of such compositions to subjects in need thereof.

07-18-2013

20130158565

AUTOMATED IN-BORE MR GUIDED ROBOTIC DIAGNOSTIC AND THERAPEUTIC SYSTEM - A medical insertion device which may be used with or installed within an imaging system, such as magnetic resonance imaging (MRI). The medical insertion device can generally be used to retain, position and effect insertion of a medical instrument, for example a biopsy device or an ablation treatment device. The device can generally provide linear and/or angular degrees of freedom for positioning of the medical instrument prior to an insertion of the medical instrument. The medical insertion device includes a mounting arm, an interface connected to the mounting arm for interfacing with a medical instrument, a mechanism for movement of the medical instrument or a part of the medical instrument in an insertion direction, a carriage connected to a distal end of the mounting arm, and a pivot connection between the carriage and the distal end of the mounting arm to permit pitch or yaw of the mounting arm.

06-20-2013

20130155932

Power saving in a device compatible with cellular and WLAN networks - A mobile communication device is able to communicate with wireless local area network and with a cellular network. A communication system is able to route a communication session between the mobile communication device and another communication device either by way of the wireless local area network or the cellular network. The communication system is able to trigger the mobile communication device via the cellular network to search for and attempt to connect to the wireless local area network. The mobile communication device, in response to reception of signaling via the cellular network, is able to activate a wireless local area network interface of the mobile communication device and to establish a connection to the wireless local area network.

LIGHT EMITTING DIODES AND SUBSTRATES - A thin layer substrate has a plurality of micron sized electrically conductive whisker components which are arranged in parallel and extending from one surface of the substrate to another surface to provide electrically conductive paths though the substrate. Such a substrate may be usable for micron sized LEDs.

05-23-2013

20130119518

SEMICONDUCTOR FORMATION BY LATERAL DIFFUSION LIQUID PHASE EPITAXY - A method for growing semiconductor wafers by lateral diffusion liquid phase epitaxy is described. Also provided are a refractory device for practicing the disclosed method and semiconductor wafers prepared by the disclosed method and device. The disclosed method and device allow for significant cost and material waste savings over current semiconductor production technologies.

05-16-2013

20130090388

METHOD OF TREATING GAUCHER DISEASE - Therapeutic compositions and methods for treatment of late-onset Gaucher disease are described herein. The compositions comprise compounds having activity as pharmacological chaperones for mutant forms of the beta-glucocerebrosidase. Methods of treatment involve providing therapeutically effective amounts of such compositions to subjects in need thereof.

04-11-2013

20130003703

WLAN-To-WWAN Handover Methods And Apparatus Using A WLAN Support Node Having A WWAN Interface - A mobile device establishes and maintains a voice call via a wireless local area network (WLAN). During voice call handover, the mobile device receives, from the cellular network, voice data of the voice call which is routed via a network support node. The network support node is connected to the WLAN and has a wireless link with a base station of the cellular network, for sending the voice data to the mobile device. The mobile device also sends, to the cellular network, voice data of the voice call which is communicated to the network support node over the wireless link with the base station.

01-03-2013

20130001137

NANOPARTICLE FLOTATION COLLECTORS - The present disclosure relates to a process for collecting a particulate material from a mixture comprising treating the mixture with hydrophobic nanoparticles under conditions to adsorb the hydrophobic nanoparticles to the particulate material and collecting the particulate material by flotation.

01-03-2013

20120300678

Conferencing PSTN Gateway Methods And Apparatus To Facilitate Heterogeneous Wireless Network Handovers For Mobile Communication Devices - For initially establishing a voice call, a first connection leg for the voice call is established between a mobile device operating in a wireless network and a conference room of a conferencing gateway. A second connection leg is established via the conferencing gateway between a processor and a communication device connected in a telephone network. Subsequently, the processor sends a message to the conferencing gateway for transferring the second connection leg from between the processor and the communication device to the conference room and the communication device, for initially establishing the voice call. The conference gateway is configured to combine media streams of connection legs of the voice call.

TRANSFORMED HUMAN PLURIPOTENT STEM CELLS AND ASSOCIATED METHODS - The present disclosure provides transformed human pluripotent stem cell (t-hPSC). t-hPSCs are not dependent on Oct4 for renewal and survival, however exhibit a sensitivity to reduced levels of the transcription factor Nanog. Also provided are methods of culturing cells for use in a cell-based screening assay comprising placing one or more transformed human pluripotent stem cells into a receptacle and culturing said stem cells in the receptacle to form a monolayer of stem cells without cell overlap. Methods of screening compounds using t-hPSCs are also described.

10-04-2012

20120236217

LIGHT EMITTING DIODE ILLUMINATION DISPLAY - A display illumination module for the illumination of a rear-projection screen is provided in which an array of light sources are positioned adjacent to an optical modulating array layer for modulating the transmission of light emitted by the light sources. The light sources emit light within a defined angular range, and the optical modulating array layer is positioned relative to the array of light sources so that light from adjacent light sources does not overlap with the optical modulating array layer. One or more display modules may be incorporated into a display system that further comprises a rear projection screen that is preferably spatially offset from the optical modulating array layer so that light from adjacent light sources of a common colour overlaps on the screen. A composite display with seamless edge blending may be obtained by tiling multiple display illumination modules behind a common rear-projection screen.

GENERATING INDUCED PLURIPOTENT STEM CELLS AND PROGENITOR CELLS FROM FIBROBLASTS - The present disclosure provides a method of generating progenitor cells, such as hematopoietic or neural progenitor cells, from fibroblasts, such as dermal fibroblasts, comprising providing fibroblasts that express or are treated with a POU domain containing gene or protein and culturing the cells under conditions that allow production of progenitor cells, without traversing the pluripotent state. Also provided is a method of isolating a subpopulation of fibroblasts with reprogramming potential comprising providing fibroblasts that express an Oct-4-reporter and isolating cells that are positive for the reporter. Further provided is a method of generating reprogrammed fibroblast-derived induced pluripotent stem cells. Also provided are uses and assays of the cells produced by the methods of the disclosure.

08-23-2012

20120213138

Wireless Access Point Methods And Apparatus Using Dynamically-Activated Service Intervals - Techniques in a mobile communication device for communicating with a wireless access point (AP) are described. The mobile device receives from the AP data which indicate a plurality of activated service intervals in the superframe that are made available to mobile devices for communication access. The mobile device attempts to access, during the indicated activated service intervals, a radio medium via the AP. The mobile device refrains from attempting to access the radio medium via the AP during each power conservation interval provided in between the indicated activated service intervals.

08-23-2012

20120208225

MODIFIED PEPTIDE SUBSTRATE - The invention provides novel reagents and methodologies for detecting free versus bound enzyme. It is particularly useful to detect thrombin when it is not bound to A2M in the presence of thrombin bound to A2M by using a modified substrate that is sterically hindered from reacting with the bound thrombin.

08-16-2012

20120135437

BIOSENSORS UTILIZING INK JET-PRINTED BIOMOLECULE COMPATIBLE SOL GEL INKS AND USES THEREOF - Novel solid-phase biosensors that utilize ink jet printing of biocompatible sol-gel based inks to create sensor strips are reported herein. Biomolecules and other reagents useful in bioassays to detect, for example, pathogenic microorganisms or toxic substances, are immobilized on a substrate, which can be paper based, by layering these substances between two layers of biomolecule compatible sol gel. The sol gel precursor solutions and solutions of the assay reagents are printed from separate nozzles in a layered approach which avoids clogging of the nozzles by the pre-mature gelling of the sol gel precursor solution. In certain embodiments of the application, a capture agent is used to concentrate a compound to be detected in specific areas on the substrate to facilitate detection.

05-31-2012

20120087343

WLAN-To-WWAN Handover Methods And Apparatus Using A WLAN Support Node Having A WWAN Interface - A network support node which includes a local area network (LAN) interface and a cellular RF interface is provided. The LAN interface is configured to connect the network support node as a LAN node in a LAN. The cellular RF interface is configured to provide wireless communications over a wireless communication link with a base station of a cellular network, such that the network support node operates as a client end station with the base station. The network support node receives, from the LAN via the LAN interface, data of a communication session between a mobile communication device and another communication device. The network support node communicates with the mobile communication device, via the cellular RF interface over the wireless communication link with the base station, the data of the communication session.

04-12-2012

20120067402

SOLAR COLLECTION AND LIGHT REGULATION APPARATUS - A solar window apparatus for collecting solar energy and regulating light transmission is provided in which the solar window comprises a plurality of transparent optical elements adhered to an internal surface of a transparent pane. The optical elements each comprise an externally facing surface and an internally facing light collecting surface with a light collecting element adhered thereto, where the externally facing surface preferably has an area that is larger than that of the light collecting surface. Each optical element further comprises two or more light directing surfaces that internally reflect and concentrate light onto the light collecting elements when light is incident over a first range of angles, and transmit light when light is incident over a second range of angles.

03-22-2012

20120023149

BIT-WIDTH ALLOCATION FOR SCIENTIFIC COMPUTATIONS - Methods and devices for automatically determining a suitable bit-width for data types to be used in computer resource intensive computations. Methods for range refinement for intermediate variables and for determining suitable bit-widths for data to be used in vector operations are also presented. The invention may be applied to various computing devices such as CPUs, GPUs, FPGAs, etc.

01-26-2012

20120021487

METHOD OF TREATING GAUCHER DISEASE - Therapeutic compositions and methods for treatment of late-onset Gaucher disease are described herein. The compositions comprise compounds having activity as pharmacological chaperones for mutant forms of the beta-glucocerebrosidase. Methods of treatment involve providing therapeutically effective amounts of such compositions to subjects in need thereof.

01-26-2012

20110313739

HYBRID MODELS OF MULTI-COMPONENT VAPOR LIQUID SEPARATION EQUIPMENT - Four different forms of hybrid models of vapor-liquid separation equipment. These are: (i) hybrid models for monitoring the equipment operation based on the plant operating data, (ii) a predictive hybrid model which computes product properties if feed properties are known (iii) a predictive hybrid model which can compute product qualities from the flows entering or leaving the tower without having to know the feed properties, and (iv) a feed properties identification hybrid model.

12-22-2011

20110294125

COLORIMETRIC BIOSENSOR WITH ALLOSTERIC DNAZYME ACTIVATION AND ROLLING CIRCLE SIGNAL AMPLIFICATION - The present disclosure includes a method of determining the presence of a target in a sample comprising an allosteric DNAzyme; rolling circle amplification dependent on the activity of the allosteric DNAzyme in the presence of target and a detection system. The methods further comprise quantifying the amount of target in the sample by comparing the detection with a control. Also included herein are kits for practicing the methods described herein and methods of designing biosensor systems.

ENDOSCOPIC DEVICE WITH END EFFECTOR MECHANISM - An endoscopic device and associated method of use. The endoscopic device includes a tubular portion and an end effector mechanism for mounting at an end of the tubular portion. The end effector mechanism includes a casing defining a cavity open to an exterior of the casing. A manipulator member is nested within the cavity of the casing and extendable to protrude to the exterior of the casing. The manipulator member includes a plurality of serially coupled manipulator segments and ending with a last manipulator segment. Each manipulator segment is pivotally connected to an adjacent manipulator segment. A surgical end effector tool such as a gripper or cutter is mounted at the last manipulator segment. A mechanical control may be located within the casing and used for mechanically controlling of the manipulator member. The endoscopic device may operate from a single port or natural orifice of a patient.

07-21-2011

20110085533

Limited-Use Data Rates in a Wireless Local Area Network - A wireless access point supports data rates and advertises an indication of a minimum data rate for advertisement. Those of the supported data rates that are less than the minimum data rate for advertisement are reserved for limited use. A mobile station that requests to communicate with the wireless access point at one of the one or more supported data rates that are reserved for limited use is informed by the wireless access point how much time communications with the wireless access point at one or more of the one or more supported data rates reserved for limited use will be permitted.

04-14-2011

20110084871

Cognitive tracking radar - Methods and systems relating to a cognitive tracking radar system. A radar system determines an immediately preceding state of a target being tracked. Based on this immediately preceding state, the system determines parameters and waveforms which may be used to better illuminate the target. These parameters and waveforms are then used when illuminating the target. The state of the target is then measured from the reflected returns of the illuminating waveform. The newly received measurements then form the basis for the new state of the target and the procedure is repeated.

04-14-2011

20110059441

METHOF OF PRODUCING BIOACTIVE PAPER - The present disclosure relates to methods for attaching bioactive agents to paper products by contacting the paper with a solution comprising colloidal support particles where said colloidal support particles are associated with bioactive agents. In specific embodiment of the disclosure, the colloidal support particles are functionalized poly(N-isopropylacrylamide) microgels. The disclosure further covers the bioactive paper produced by this method as well as uses thereof, in particular for pathogen detection.

03-10-2011

20110034205

Power Saving in a Device Compatible with Cellular and WLAN Networks - A mobile communication device is able to communicate with wireless local area network and with a cellular network. A communication system is able to route a communication session between the mobile communication device and another communication device either by way of the wireless local area network or the cellular network. The communication system is able to trigger the mobile communication device via the cellular network to search for and attempt to connect to the wireless local area network. The mobile communication device, in response to reception of signaling via the cellular network, is able to activate a wireless local area network interface of the mobile communication device and to establish a connection to the wireless local area network.

02-10-2011

20110015649

Surgical Guidance Utilizing Tissue Feedback - A surgical system is for use with a surgical tool and a tissue characteristic sensor associated with the surgical tool. The system has an expected tissue characteristic for tissue on a predefined trajectory of the tool in a patient, and a controller to receive a sensed tissue characteristic from the tissue characteristic sensor, such sensed tissue characteristic associated with an actual trajectory of the tool. The controller compares the expected tissue characteristic for the expected location with the sensed tissue characteristic for the actual trajectory. A robot can be used to carry out automated surgical tasks and make adjustments based on differences between the expected characteristic and the sensed characteristic.

01-20-2011

20100260051

Adaptive Voice Packetization - A method is presented for adapting the packet size for VoIP communications, determined on-the-fly by the total network delay inherent at the time of packet transmission. If network delays are small relative to the maximum permissible latency for VoIP communications, the payload size per packet may be increased to maximize efficiency for the transmitted call. Alternatively, if network delays are large, the payload size per packet may be decreased in order to assure that the perceived quality of the transmitted call is acceptable.

10-14-2010

20100246460

Wireless Access Point Methods And Apparatus Using Dynamically-Activated Service Intervals - Methods and apparatus for controlling a wireless access point (AP) (e.g. a battery-powered wireless AP) for reduced power consumption are provided. In one illustrative example, the AP is adapted to provide communication access for end stations in one or more activated service intervals of each superframe. During operation, the AP changes the number of activated service intervals that are available to end stations for the communication access, as well as the durations of their active subinterval durations, in accordance with a change in traffic requirements. The AP regularly broadcasts data which indicates the activated service intervals that are made available to the mobile devices. A wireless transceiver of the AP is enabled during each activated service interval made available to the mobile devices, but the AP is placed in a power conservation mode during each deactivated service interval provided in between the activated service intervals. The AP may also be placed in the power conservation mode during inactive subintervals of each activated service interval.

METHOD FOR PREDICTING CARDIOVASCULAR EVENTS - A novel method for assessing the risk of a cardiovascular event is provided. The concentration of 11-dehydro thromboxane in a urine sample is measured and compared to a set of standardized quartile concentrations. A concentration of urinary 11-dehydro thromboxane that falls within the fourth quartile is indicative of a greatly increased risk of a recurrent cardiovascular event.

02-18-2010

20100012628

ABRASION ASSISTED WIRE ELECTRICAL DISCHARGE MACHINING PROCESS - A method of wire electrical discharge machining comprising applying a pulsed voltage between a tool electrode and a workpiece which are physically separated by a working gap, the tool electrode being in the form of a wire with an electrically conductive core and an external surface embedded with an electrically non-conductive abrasive material.

01-21-2010

20090176052

COMPOSITE MATERIAL COMPRISING A NON-CROSSLINKED GEL POLYMER - Disclosed is a composite material comprising a support member that has a plurality of pores extending therethrough, which pores are durably filled or coated with a non crosslinked gel polymer. Also disclosed is a process for the preparation of the composite material, use of the composite material as a separation medium, and a filtering apparatus comprising the composite material.

07-09-2009

20090154384

Resource allocation and outage control for renewable energy WLAN infrastructure mesh node - A mesh node of an infrastructure wireless local area network ‘WLAN’ is coupled to a battery which is coupled to a device that is able to harness energy from a source of renewable energy. Energy management of the mesh node includes conducting simulations of a system comprising the mesh node, the device, and the battery in its current state of charge, determining an admissible load for the mesh node from the simulations, and withholding communication services by the mesh node for one or more periods of time a cumulative duration of which is related to power consumption of the mesh node when handling the admissible load. The simulations involve meteorological data related to the source of renewable energy in the vicinity of the mesh node.

Technetium- and rhenium-bis(heteroaryl) complexes, and methods of use thereof - One aspect of the invention relates to complexes of technetium (Tc) and rhenium (Re) with various heteroaromatic ligands, e.g., quinolinyl and isoquinolinyl ligands, and their use in fluorescence and radioimaging for a variety of clinical diagnostic applications, as well as radiopharmaceuticals for therapeutic applications. Another aspect of the invention relates to quinolinyl and isoquinolinyl ligands that form a portion of the aforementioned complexes. Methods for the preparation of the technetium and rhenium complexes are also described. Another aspect of the invention relates to quinolinyl and isoquinolinyl ligands based on derivatized lysine, alanine and bis-amino acids for conjugation to small peptides by solid phase synthetic methods. Additionally, the invention relates to methods for imaging regions of a mammal using the complexes of the invention.

06-11-2009

20090118456

CHELATING SILICON-BASED POLYMERS - The present invention relates to novel silicon-based polymers, particularly silicon-based polymers having citrate groups, and their use as chelating agents, for forming and as stabilizers.

05-07-2009

20090075960

Method of treating gaucher disease - Therapeutic compositions and methods for treatment of late-onset Gaucher disease are described herein. The compositions comprise compounds having activity as pharmacological chaperones for mutant forms of the beta-glucocerebrosidase. Methods of treatment involve providing therapeutically effective amounts of such compositions to subjects in need thereof.

03-19-2009

20080255305

Biological Molecule-Reactive Hydrophilic Silicone Surface - A silicone polymer having a modified surface is described, wherein said modification consists of a covalently attached water soluble polymer bearing an activating group, wherein said activating group reacts with reactive functionalities on one or more biological molecules so that said one or more biological molecules become covalently attached to said silicone polymer. The modified silicones are reacted with biological molecules to make them more biocompatible for use in biodiagnostic, biosensor or bioaffinity applications, or for coatings for in vivo transplantation or for liners exposed to biological broths.