Referencia bibliográfica

Resumen

A matrix dispersion type transdermal drug delivery system of domperidone was developed using different ratios of rosin with Eudragit RL and Eudragit RS. The effect of the polymers on the technological properties, i.e., drug release, water vapor transmission rate, percentage moisture loss and thickness were investigated. The patch containing Eudragit RL: Eudragit RS (8:2) showed a release of 87.10% in 12 h. Formulation D1 emerged as the most satisfactory formulation as far as the technological properties were concerned. Further skin permeation and skin irritation studies were carried out on rat skin and rabbit respectively. Therefore it can be concluded that the patch containing Eudragit RL: Eudragit RS in the ratio 8:2 achieved the desired objectives of transdermal drug delivery systems, such as overcoming of first pass effect, extended release and reduced frequency of administration.