Knight originally self-published The Taqwacores in DIYzine format, giving copies away for free until finding distribution with Alternative Tentacles, the punk record label founded by Jello Biafra. After receiving an endorsement from Peter Lamborn Wilson (aka Hakim Bey), the novel was published by radical press Autonomedia. A UK version is published by Telegram Books. In its Italian translation, the novel is retitled Islampunk.

The narrator of The Taqwacores, Yusuf Ali, is a Pakistani American engineering student from Syracuse, New York, who lives off campus with a diverse group of Muslims in their house in Buffalo. Besides being their home, the house serves as a place to have punk parties and a place for Muslims not comfortable with the Muslim Student Association or local mosques to have Friday prayer.

The book also inspired a documentary entitled Taqwacore: The Birth of Punk Islam, directed by Omar Majeed, which follows author Michael Muhammad Knight and several Taqwacore bands across the United States. It was released in Montreal, Canada, at the Cinéma du Parc on October 19, 2009.

Soft Skull Press is publishing the revised edition, which became available in December 2008.