From Minsk you should keep the road P1, then take the highway M1/E30 until Brest; after you enter the city of Brest you should go all the time straight along Moskovskaya St, further Masherov Av till the crossroads with Lenin St, where you should turn to the right and go till Gogol St where you should turn to the left and go till the sign "Hotel" Vesta ".

Location map:

If you take public transportyou should get off at the stop "Lenin Square" or "Drama and Music Theatre"