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Dose and side effects of sublingual misoprostol for treatment of postpartum hemorrhage: What difference do they make?

This article reports on a study to assess whether a 600 mcg sublingual dose of misoprostol would reduce the incidence of shivering and high fever seen in a previous study that used an 800 mcg sublingual regimen to treat postpartum hemorrhage in Ecuador. While the rate of both shivering and fever remained the same, the incidence of high fever was 55% lower than in the previous study. However, without substantial evidence regarding efficacy of the lower dose, the 800 mcg regimen is still recommended.