This additional research area has been added in response to an NIDDK-sponsored workshop on this topic on February 20, 2012, see: http://www2.niddk.nih.gov/News/Calendar/Hema2012.htm. Applications that focus on leukemia and its pathogenesis will not be accepted. Research areas to be addressed include, but are not limited to:

Clarification of how the hematopoietic stem cell niche influences the epigenetic and transcriptional regulation of HSC self-renewing potential vs. lineage commitment, including signaling networks that impact the fate of HSC.