This study examined concurrent associations and predictors at first indication of nonadherence to antipsychotic medication four years after a first episode of psychosis.; A prospective cohort of 171 patients in urban Ireland with a first episode of psychosis was followed up four years after inception (follow-up primary analysis, N=84; secondary analysis, N=104).; At the four-year follow-up 76% were adherent and 24% were not. Nonadherence was concurrently associated with substance misuse (p<.01), increased symptomatology (p<.01), less insight (p=.01), lower global functioning (p<.01), and negative attitudes toward medication (p<.01). Compared with other patients, those who were nonadherent had more readmissions (p=.01). Predictors of future nonadherence were substance misuse (p=.02) and duration of untreated psychosis (p=.04).; This prospective investigation confirms previous cross-sectional studies. The association between longer duration of untreated psychosis and nonadherence warrants further research because it could be interpreted as further evidence of the importance of early intervention.

Nonadherence to medication four years after a first episode of psychosis and associated risk factors. 2010, 61 (2):189-92 Psychiatr Serv

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dc.identifier.issn

1557-9700

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dc.identifier.pmid

20123826

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dc.identifier.doi

10.1176/appi.ps.61.2.189

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dc.identifier.uri

http://hdl.handle.net/10147/221216

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dc.description.abstract

This study examined concurrent associations and predictors at first indication of nonadherence to antipsychotic medication four years after a first episode of psychosis.

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dc.description.abstract

A prospective cohort of 171 patients in urban Ireland with a first episode of psychosis was followed up four years after inception (follow-up primary analysis, N=84; secondary analysis, N=104).

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dc.description.abstract

At the four-year follow-up 76% were adherent and 24% were not. Nonadherence was concurrently associated with substance misuse (p<.01), increased symptomatology (p<.01), less insight (p=.01), lower global functioning (p<.01), and negative attitudes toward medication (p<.01). Compared with other patients, those who were nonadherent had more readmissions (p=.01). Predictors of future nonadherence were substance misuse (p=.02) and duration of untreated psychosis (p=.04).

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dc.description.abstract

This prospective investigation confirms previous cross-sectional studies. The association between longer duration of untreated psychosis and nonadherence warrants further research because it could be interpreted as further evidence of the importance of early intervention.

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dc.language.iso

en

en

dc.rights

Archived with thanks to Psychiatric services (Washington, D.C.)

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dc.subject.mesh

Adult

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dc.subject.mesh

Antipsychotic Agents

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dc.subject.mesh

Cohort Studies

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dc.subject.mesh

Comorbidity

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dc.subject.mesh

Female

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dc.subject.mesh

Follow-Up Studies

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dc.subject.mesh

Humans

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dc.subject.mesh

Ireland

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dc.subject.mesh

Male

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dc.subject.mesh

Medication Adherence

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dc.subject.mesh

Middle Aged

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dc.subject.mesh

Outcome Assessment (Health Care)

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dc.subject.mesh

Patient Readmission

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dc.subject.mesh

Prospective Studies

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dc.subject.mesh

Psychiatric Status Rating Scales

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dc.subject.mesh

Psychotic Disorders

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dc.subject.mesh

Social Adjustment

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dc.subject.mesh

Substance-Related Disorders

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dc.subject.mesh

Urban Population

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dc.subject.mesh

Young Adult

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dc.title

Nonadherence to medication four years after a first episode of psychosis and associated risk factors.

en_GB

dc.type

Article

en

dc.contributor.department

St. John of God Adult Psychiatric Service, Cluain Mhuire Family Centre, Dublin, Ireland.