Total intravenous anesthesia (propofol and remifentanil) is provided using the close-loop system. A muscle relaxant is used to facilitate tracheal intubation; its administration is continued throughout anesthesia.

Drug: muscle relaxant

muscle relaxant administration throughout anesthesia

Experimental: 2

Total intravenous anesthesia (propofol and remifentanil) is provided using the close-loop system. No muscle relaxant is used and a placebo is infused throughout anesthesia.

Drug: normal saline

no muscle relaxant throughout anesthesia (normal saline infused as a placebo)

Eligibility

Ages Eligible for Study:

18 Years and older

Genders Eligible for Study:

Both

Accepts Healthy Volunteers:

No

Criteria

Inclusion Criteria:

patients scheduled for a surgical procedure which not require a myorelaxation

Exclusion Criteria:

age less than 18 years,

ASA III and above,

pregnant woman

combined general and regional anesthesia,

history of prolonged myorelaxation due to a decrease in cholinesterase,

patient with a known lack in cholinesterase,

history of cerebral or psychiatric central,

allergy to latex, propofol, remifentanil, morphine, muscle relaxant or any of the excipients,

known hypersensitivity to remifentanil or to an other derivative of fentanyl,

presence of a pacemaker,

psychotropic or agonist-antagonist morphine treatment,

planned post-operative sedation.

Contacts and Locations

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study.
To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below.
For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00886418