Previous HGNC Symbols for IFT81 Gene

Previous GeneCards Identifiers for IFT81 Gene

Summaries for IFT81 Gene

Entrez Gene Summary for IFT81 Gene

The protein encoded by this gene, together with IFT74, forms a tubulin-binding module of intraflagellar transport complex B. This module is involved in transport of tubulin within the cilium, and the encoded protein is required for ciliogenesis. Mutations in this gene are a cause of short-rib polydactyly syndromes. [provided by RefSeq, Dec 2016]

UniProtKB/Swiss-Prot for IFT81 Gene

Component of the intraflagellar transport (IFT) complex B: together with IFT74, forms a tubulin-binding module that specifically mediates transport of tubulin within the cilium. Binds tubulin via its CH (calponin-homology)-like region. Required for ciliogenesis.

Protein details for IFT81 Gene (UniProtKB/Swiss-Prot)

Protein attributes for IFT81 Gene

Size:

676 amino acids

Molecular mass:

79746 Da

Quaternary structure:

Component of the IFT complex B, at least composed of IFT20, IFT22, HSPB11/IFT25, IFT27, IFT46, IFT52, TRAF3IP1/IFT54, IFT57, IFT74, IFT80, IFT81, and IFT88. Interacts with IFT74; the interaction is direct: within the IFT complex B, IFT74 and IFT81 mediate the transport of tubulin within the cilium. Interacts with tubulin; the interaction is direct. Interacts with RABL2/RABL2A; binding is equal in the presence of GTP or GDP. Interacts with IFT88.

Function for IFT81 Gene

Products:

Molecular function for IFT81 Gene

UniProtKB/Swiss-Prot Function:

Component of the intraflagellar transport (IFT) complex B: together with IFT74, forms a tubulin-binding module that specifically mediates transport of tubulin within the cilium. Binds tubulin via its CH (calponin-homology)-like region. Required for ciliogenesis.

No data available for
mRNA differential expression in normal tissues ,
Protein tissue co-expression partners and
Phenotype-based relationships between genes and organs from Gene ORGANizer
for IFT81 Gene