Evaluation of serum neuon-specific enolase and its half-life analysis in diagnosis and follow-up of small cell lung cancer

ObjectiveTo evaluate the clinical value of detection of serum neuron specific enolase (S NSE) level and its half life in differential diagnosis, monitoring of chemotherapy and prediction of relapse of small cell lung cancer(SCLC).MethodsThe double mAb sandwich ELISA was used.ResultsUsing 20ng/ml of the cut off value for SCLC,the sensitivity, specificity, acuracy of the ELISA for detection of serum NSE were 81.8%, 91.6% and 89 5%, respectively. The positive rates of serum NSE detected in limited disease (LD) and extensive disease(ED) patients with SCLC were 72 7% and 90 9%. The patients whose serum NSE halflife were more than 20ds, the relapse would be found from 43～193d since they had been found to be SCLC, the sensitivity of prediction of relapse by half life of NSE was 83 3%.ConclusionDetection of serum NSE level is of significance in differentiation between SCLC and NSCLC. The half life of serum NSE predicted the relapse of SCLC were better than the detection of serum NSE. [