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You can generally switch amongst diapers without problem, unless your baby has very sensitive skin and reacts to things easily. That said, the only issue may be is if you find a crappy diaper and don't change baby often enough... diaper rash may be more likely. So if I am using a cheap brand I've never tried before, I am more careful about checking him often since it's hard to know how much each brand can actually hold before moisture will be against baby's skin. With Pampers he can last all night and sometimes still doesn't max the thing out (although we DO change him every morning anyway!). Some cheaper brands, not so much...and he will wake up red. Aside from that tid bit... it's fine to switch. Diapers aren't like formula in that way. lol.