Children will receive 0.5 mg/ml budesonide nebules every 20 minutes for 3 times and will not give after 3 doses

Drug: 0.5 mg/ml budesonide nebules

Children will receive 0.5 mg/ml budesonide nebules every 20 minutes for 3 times

Other Name: Budesonide 0.5 mg/ml nebules

Placebo Comparator: 2- 0.9% saline

Children will receive 2 ml of saline every 20 minutes for 3 times and will not give after 3 doses

Drug: Saline

Children will receive 2 ml of saline every 20 minutes for 3 times

Other Name: 0.9% Saline solution

Detailed Description:

Context: Inhaled steroids reduced admission rates in patients with acute asthma, but it is unclear if there is a benefit of inhaled corticosteroids when used in addition to systemic corticosteroids. There is insufficient evidence that inhaled corticosteroids result in clinically important changes in pulmonary function or clinical scores when used in acute asthma. Similarly, it was mentioned in the Cochrane Database of Systematic Reviews that further research is needed to clarify if there is a benefit of inhaled corticosteroids when used in addition to systemic steroids.

Objective: To determine if adding nebulized budesonide to the systemic steroid for treatment of acute wheezing in the emergency room has any benefit on, symptom score, hospitalization rate and time to discharge from emergency room.

Study Design/Setting/Participants: A double-blind, randomized, controlled trial of nebulized budesonide versus placebo for children 6 months to 6 years of age who have admitted to the emergency room for acute wheezing.

Intervention: Participants will receive standard therapy including SCS, albuterol, and ipratropium bromide and will be randomly assigned to also receive either nebulized BIS or saline.

Study Measures: Differences in asthma scores, vital signs, and the need for hospitalization will be compared between treatment groups.

Eligibility

Ages Eligible for Study:

6 Months to 6 Years

Genders Eligible for Study:

Both

Accepts Healthy Volunteers:

No

Criteria

Inclusion Criteria:

Children who have recurrent wheezing attacks and admitted to the emergency room for acute wheezing

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Please refer to this study by its ClinicalTrials.gov identifier: NCT00733317