Development of a Multi-Residue Method for Monitoring 44 Pharmaceuticals in Slovene Surface Water by SPE-LC-MS/MS

Development of a Multi-Residue Method for Monitoring 44 Pharmaceuticals in Slovene Surface Water...
Klančar, Anita; Trontelj, Jurij; Roškar, Robert
2018-05-31 00:00:00
The article describes a novel analytical method based on solid-phase extraction and LC-MS/MS for detection of a high number (n = 44) of selected pharmaceuticals in surface waters. The validated method showed suitable accuracy, precision, and linearity. The extraction efficiency for pharmaceuticals was mostly above 90% and the determined LOQs were generally below 5 ng/L and even down to 0.03 ng/L. The matrix effect was successfully minimized with isotopically labeled internal standards. Six river and lake samples from Slovene regions were afterwards analyzed. Forty-two of the 44 target pharmaceuticals were detected in at least two water samples; 66% of them were detected in all samples. Three analytes were present above the LOQ in all samples: caffeine (1.1–3.1 ng/L), irbesartan (0.2–9.3 ng/L), and valsartan (0.8–47 ng/L). The highest concentration was measured for valsartan. Comprehensive comparison with the literature data showed that the found concentrations of pharmaceuticals were notably lower in our study and that a number of the pharmaceuticals had not been reported previously. Comparison of the measured and predicted (calculated) environmental concentrations of pharmaceuticals in surface waters showed high discrepancy between the two approaches, clearly indicating the need for comprehensive analytical methods for routine monitoring of these newly emerging pollutants. In conclusion, our method was proven to be adequately sensitive to reliably quantify the majority of pharmaceutical contaminants even though they were found in notably lower concentrations in Slovenian surface waters than it was predicted from their consumption and from the literature.
http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.pngWater, Air, & Soil PollutionSpringer Journalshttp://www.deepdyve.com/lp/springer-journals/development-of-a-multi-residue-method-for-monitoring-44-Kzr4yweNjg

Development of a Multi-Residue Method for Monitoring 44 Pharmaceuticals in Slovene Surface Water by SPE-LC-MS/MS

Abstract

The article describes a novel analytical method based on solid-phase extraction and LC-MS/MS for detection of a high number (n = 44) of selected pharmaceuticals in surface waters. The validated method showed suitable accuracy, precision, and linearity. The extraction efficiency for pharmaceuticals was mostly above 90% and the determined LOQs were generally below 5 ng/L and even down to 0.03 ng/L. The matrix effect was successfully minimized with isotopically labeled internal standards. Six river and lake samples from Slovene regions were afterwards analyzed. Forty-two of the 44 target pharmaceuticals were detected in at least two water samples; 66% of them were detected in all samples. Three analytes were present above the LOQ in all samples: caffeine (1.1–3.1 ng/L), irbesartan (0.2–9.3 ng/L), and valsartan (0.8–47 ng/L). The highest concentration was measured for valsartan. Comprehensive comparison with the literature data showed that the found concentrations of pharmaceuticals were notably lower in our study and that a number of the pharmaceuticals had not been reported previously. Comparison of the measured and predicted (calculated) environmental concentrations of pharmaceuticals in surface waters showed high discrepancy between the two approaches, clearly indicating the need for comprehensive analytical methods for routine monitoring of these newly emerging pollutants. In conclusion, our method was proven to be adequately sensitive to reliably quantify the majority of pharmaceutical contaminants even though they were found in notably lower concentrations in Slovenian surface waters than it was predicted from their consumption and from the literature.

Journal

Water, Air, & Soil Pollution
– Springer Journals

Published: May 31, 2018

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References

Pharmaceuticals in STP effluents and their solar photodegradation in aquatic environment

Andreozzi, R; Raffaele, M; Nicklas, P

Screening of pharmaceuticals and illicit drugs in wastewater and surface waters of Spain and Italy by high resolution mass spectrometry using UHPLC-QTOF MS and LC-LTQ-Orbitrap MS

Development of a multi-residue analytical methodology based on liquid chromatography-tandem mass spectrometry (LC-MS/MS) for screening and trace level determination of pharmaceuticals in surface and wastewaters

Gros, M; Petrović, M; Barceló, D

Multi-residue analytical methods using LC-tandem MS for the determination of pharmaceuticals in environmental and wastewater samples: a review

Gros, M; Petrović, M; Barceló, D

Occurrence and fate of antibiotic, analgesic/anti-inflammatory, and antifungal compounds in five wastewater treatment processes

Guerra, P; Kim, M; Shah, A; Alaee, M; Smyth, SA

Occurrence and removal of frequently prescribed pharmaceuticals and corresponding metabolites in wastewater of a sewage treatment plant

Gurke, R; Rossler, M; Marx, C; Diamond, S; Schubert, S; Oertel, R

Net changes in antibiotic concentrations downstream from an effluent discharge

Haggard, BE; Bartsch, LD

Environmental hazard assessment of pharmaceuticals

Henschel, KP; Wenzel, A; Diedrich, M; Fliedner, A

Microbial atrazine breakdown in a karst groundwater system and its effect on ecosystem energetics

Development of a fast instrumental method for the analysis of pharmaceuticals in environmental and wastewaters based on ultra high performance liquid chromatography (UHPLC)–tandem mass spectrometry (MS/MS)

López-Serna, R; Petrović, M; Barceló, D

Occurrence of 95 pharmaceuticals and transformation products in urban groundwaters underlying the metropolis of Barcelona, Spain