Deconstructing the cadherin-catenin-actin complex.

This study, along with a companion paper from the same labs {1}, calls into question the standard textbook view of how the cadherin-catenin complex (CCC) links to the actin cytoskeleton.

The standard view, in which cadherin binds to beta catenin, which binds to alpha catenin, which in turn binds to actin, predicts a quaternary complex of these four proteins.

Yamada et al. show that a complex of all four proteins cannot be isolated...

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