Low Density Lipoprotein Receptor (LDLR) ELISA Kits

The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Additionally we are shipping LDLR Antibodies (224) and LDLR Proteins (27) and many more products for this protein.

The absence of PCSK9 (show PCSK9 ELISA Kits) results in a sex- and tissue-specific subcellular distribution of the LDLR and VLDLR (show VLDLR ELISA Kits), which is determined by estradiol levels.

In the present study, we examined the effects of H2 on atherosclerotic plaque stability and the underlying mechanisms in low-density lipoprotein receptor-knockout (LDLR-/-) mice and macrophage-derived foam cell models.

found association between genotypes for LDLR and APOB (show APOB ELISA Kits) polymorphisms and serum lipid levels, but none of them seem to be the causal mutation but probably represent closely linked polymorphisms

LDLR Antigen Profile

Antigen Summary

The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.