When running nghttpx as a front end proxy and OCSP Stapling is attempted, an error "ocsp query command for /../../cert.pem failed: error=0, rstatus=100, status=1" This happens because a Python script, /usr/local/share/nghttpx/fetch-ocsp-response, is executed to check ssl certificates.
The problem: the script is missing the #!/usr/bin/env on the first line of the file.
The fix: I do not know how to create a portable version but inserting '#!/usr/bin/env python2.7' on the first line removed the erros and OCSP stapling is working for me now.