..Recognizing this, we conducted a multistep process to develop ICD-10 coding algorithms to define Charlson and Elixhauser comorbidities in administrative data and assess the performance of the resulting algorithms...

Predictors of hospital mortality in the global registry of acute coronary events

..Infection is a major cause of morbidity and mortality in intensive care units (ICUs) worldwide. However, relatively little information is available about the global epidemiology of such infections...

..It is uncertain whether lower levels of staffing by nurses at hospitals are associated with an increased risk that patients will have complications or die...

Characteristics and outcomes of patients hospitalized for heart failure in the United States: rationale, design, and preliminary observations from the first 100,000 cases in the Acute Decompensated Heart Failure National Registry (ADHERE)

..Most available data on these patients are limited by patient selection criteria and study design of clinical trials and single-center studies...

Use of the SOFA score to assess the incidence of organ dysfunction/failure in intensive care units: results of a multicenter, prospective study. Working group on "sepsis-related problems" of the European Society of Intensive Care Medicine

Mohammed A MohammedUnit of Public Health, Epidemiology and Biostatistics, University of Birmingham, Birmingham B15 2TTBMJ 338:b780. 2009

..To assess the validity of case mix adjustment methods used to derive standardised mortality ratios for hospitals, by examining the consistency of relations between risk factors and mortality across hospitals...

Hospitalized patients with 2009 H1N1 influenza in the United States, April-June 2009

..Although numerous studies suggest that there is an inverse relation between hospital volume of surgical procedures and surgical mortality, the relative importance of hospital volume in various surgical procedures is disputed...

Developing a summary hospital mortality index: retrospective analysis in English hospitals over five years

..Several studies have identified higher mortality for patients admitted as emergencies at the weekend compared with emergency admissions during the week, but most have focused on specific conditions or have had a limited sample size...

A national evaluation of the effect of trauma-center care on mortality

..Accordingly, the EuroHeart Failure survey was conducted to ascertain if appropriate tests were being performed with which to confirm or refute a diagnosis of heart failure and how this influenced subsequent management...

Hospital mortality, length of stay, and preventable complications among critically ill patients before and after tele-ICU reengineering of critical care processes

The association of an adult tele-intensive care unit (ICU) intervention with hospital mortality, length of stay, best practice adherence, and preventable complications for an academic medical center has not been reported.

..ICU project, a comprehensive statewide quality improvement initiative focused on reduction of infections, was associated with reductions in hospital mortality and length of stay for adults aged 65 or more admitted to intensive care units.

The more the better?: the impact of surgeon and hospital volume on in-hospital mortality following colorectal resection

Paul J KaranicolasDepartment of Surgery, The University of Western Ontario, London, CanadaAnn Surg 249:954-9. 2009

To determine the in-hospital mortality rates for patients undergoing colorectal resection for malignant or benign conditions, and to identify risk factors for in-hospital death, particularly the relationships with surgeon and hospital ..

..renal failure is a complication in critically ill patients that has been associated with an excess risk of hospital mortality. Whether this reflects the severity of the disease or whether acute renal failure is an independent risk ..

Is worsening multiple organ failure the cause of death in patients with severe sepsis?

..We used the INDEPTH (International Integrated Database for the Evaluation of Severe Sepsis and Drotrecogin alfa activated) database to investigate the reported cause of death in patients with severe sepsis...

..AEs are unintended injuries or complications resulting in death, disability or prolonged hospital stay that arise from health care management. We estimated the incidence of AEs among patients in Canadian acute care hospitals...

Predictors of in-hospital mortality and attributable risks of death after ischemic stroke: the German Stroke Registers Study Group

..Our objective was to compare metrical and practical properties of published comorbidity scores for use in epidemiological research with administrative databases...

Variation in hospital mortality associated with inpatient surgery

Amir A GhaferiMichigan Surgical Collaborative for Outcomes Research and Evaluation, The Department of Surgery, University of Michigan, Ann Arbor 48104, USAN Engl J Med 361:1368-75. 2009

b>Hospital mortality that is associated with inpatient surgery varies widely. Reducing rates of postoperative complications, the current focus of payers and regulators, may be one approach to reducing mortality...

Effects of nurse staffing and nurse education on patient deaths in hospitals with different nurse work environments

..more educated nurses, and improved nurse work environments have been shown to be associated with lower hospital mortality. Little is known about whether and under what conditions each type of investment works better to improve ..

A validated risk score for in-hospital mortality in patients with heart failure from the American Heart Association get with the guidelines program

..However, few studies have taken age into account when examining sex differences in clinical presentation and mortality...

Severe sepsis in two Ugandan hospitals: a prospective observational study of management and outcomes in a predominantly HIV-1 infected population

Shevin T JacobDivision of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, WA, USAPLoS ONE 4:e7782. 2009

..We conducted a prospective observational study reporting the management and outcomes of severely septic patients in two Ugandan hospitals. We describe their epidemiology, management, and clinical correlates for mortality...

Female gender is an independent predictor of in-hospital mortality after STEMI in the era of primary PCI: insights from the greater Paris area PCI Registry

..However, such studies have been criticized because they have not shown a direct link between the level of staffing and individual patient experiences and have not included sufficient statistical controls...

SAPS 3--From evaluation of the patient to evaluation of the intensive care unit. Part 2: Development of a prognostic model for hospital mortality at ICU admission

..8%), methicillin-sensitive Staphylococcus aureus (13.8%), and Haemophilus influenzae (8.5%). The hospital mortality rate was statistically greater among patients with HCAP than among those with CAP (24.6% versus 9...

Trends in hospital volume and operative mortality for high-risk surgery

Jonathan F FinksCenter for Healthcare Outcomes and Policy and the Section of General Surgery, Department of Surgery, University of Michigan, Ann Arbor, USAN Engl J Med 364:2128-37. 2011

..It remains unknown whether referral patterns for high-risk surgery have changed as a result and how operative mortality has been affected...

..Previous studies have suggested that a medical emergency team responding to such patients may decrease in-hospital mortality from cardiac arrest, but the association between any abnormal clinical observation and subsequent increased ..

..We aimed to determine the incidence of critical care syndromes, organ failures, and life-support interventions in a defined US suburban community with unrestricted access to critical care services...

Representativeness of the Get With The Guidelines-Stroke Registry: comparison of patient and hospital characteristics among Medicare beneficiaries hospitalized with ischemic stroke

..We used fee-for-service Medicare claims to ascertain the representativeness of ischemic stroke admissions in GWTG-Stroke...

Trends in presenting characteristics and hospital mortality among patients with ST elevation and non-ST elevation myocardial infarction in the National Registry of Myocardial Infarction from 1990 to 2006

..Unrecognized and undertreated septic shock increases morbidity and mortality. Septic shock in children is defined as sepsis and cardiovascular organ dysfunction, not necessarily with hypotension...

Comparison of hospital risk-standardized mortality rates calculated by using in-hospital and 30-day models: an observational study with implications for hospital profiling

Elizabeth E DryeYale University School of Medicine, Yale New Haven Hospital Center for Outcomes Research and Evaluation, New Haven, Connecticut 06510, USAAnn Intern Med 156:19-26. 2012

In-hospital mortality measures, which are widely used to assess hospital quality, are not based on a standardized follow-up period and may systematically favor hospitals with shorter lengths of stay (LOSs).

Comparison of 30-day mortality models for profiling hospital performance in acute ischemic stroke with vs without adjustment for stroke severity

To evaluate the in-hospital outcome of STEMI (ST elevation myocardial infarction) patients admitted to Swiss hospitals between 2000 and December 2007, and to identify the predictors of in-hospital mortality and major cardiac events.

Effect of hospital volume on clinical outcome in patients with acute pancreatitis, based on a national administrative database

Atsuhiko MurataDepartment of Preventive Medicine and Community Health, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, JapanPancreas 40:1018-23. 2011

..This study aimed to investigate the relationship between hospital volume and clinical outcome in patients with acute pancreatitis, using a Japanese national administrative database...

Using hospital standardised mortality ratios to assess quality of care--proceed with extreme caution

Research Grants63

..time, 2) recent fluoroquinolone exposure will be a significant risk factor for CDI in SCI/D veterans, 3) in-hospital mortality will be higher for SCI/D veterans with CDI diagnosis compared to those without such a diagnosis, 4) length ..

..Reducing the preterm birth rate to 7% in the United States is a goal of the Healthy People 2010 initiative, and it is only by reducing the incidence of preterm birth that infant mortality in the United States can be addressed. ..

..rates than equally matched men in low-risk and medium-risk groups and significant differences in in-hospital mortality for women persist despite the fact that women have better cardiac function pre-operatively and fewer bypass ..

..Increasing in both incidence and severity, sepsis is also associated with extremely high in-hospital mortality rates, increased risks of death among survivors, and considerable use of healthcare resources...

..MT), defined as 10 or more units within 24 hours, consume 71% of all RBC transfusions with a 40% risk of in-hospital mortality. Plasma and platelets (separate components) are given to 90% and 71% of MT patients, respectively...

..with these methods (censored at initiation of dialysis or development of severe disarray) on predicting in-hospital mortality. Aim 2: Assess the impact of renal replacement therapy (RRT) initiated during moderate metabolic disarray on ..

..testing (EKG, chest x-ray, cardiac enzyme), medication usage, admission patterns, discharge diagnoses and in-hospital mortality. This will be accomplished by conducting a secondary data analysis of the ED portion of the National ..

..a RRS to reduce cardiac arrests on hospital medical or surgical floors, un-anticipated ICU transfers and all hospital mortality rates remains inconclusive, partly because of weak study designs and partly due to a failure of published ..

..These two knowledge gaps are significant, as public reporting of other patient outcomes (e.g., hospital mortality) has demonstrated that evaluating and reporting outcome data is complicated, and can have both intended and ..

..significantly related to the probability of a coronary artery bypass graft (CABG) patient experiencing an in-hospital mortality or perioperative complication, and (b) to use this information to assess the relative quality of care ..

..scores in predicting adverse outcomes in patients with established ARF, including dialysis requirement and hospital mortality. We will test these hypotheses in a large cohort of 300 hospitalized patients with ARF, of which over 200 ..

..outcomes (specifically increase the number of ventilator-free days to day 28 and decrease the 60-day, hospital mortality) in patients with ALI or ARDS by reducing systemic inflammation and the number of feeding complications as ..

..concentrations can risk-statify patients with AKI in terms of the need for renal replacement therapy and in-hospital mortality. The results from this study will help later guide a definitive large multicenter study by developing the ..

..in study duration) 2) time required for mechanical ventilatory support, time in the ICU, and both ICU and hospital mortality. 3) mortality as a function of initial EVLW measurement, or as a function of change in the EVLW measurement ..

This project describes Dr. Stukenborg's plan to develop improved public domain hospital mortality prediction methods for use with administrative data, in collaboration with faculty sponsors who have substantial expertise in health care ..

..consultation or closed ICU where intensivists see all patients) is associated with a 29 percent reduction in hospital mortality and a 49 percent reduction in ICU mortality. However, only 10-15 percent of U.S...

..outcomes (specifically increase the number of ventilator-free days to day 28 and decrease the 60-day, hospital mortality) in patients with ALI or ARDS by reducing systemic inflammation and the number of feeding complications as ..

..outcomes (specifically increase the number of ventilator-free days to day 28 and decrease the 60-day, hospital mortality) in patients with ALI or ARDS by reducing systemic inflammation and the number of feeding complications as ..

..outcomes (specifically increase the number of ventilator-free days to day 28 and decrease the 60-day, hospital mortality) in patients with ALI or ARDS by reducing systemic inflammation and the number of feeding complications as ..

..outcomes (specifically increase the number of ventilator-free days to day 28 and decrease the 60-day, hospital mortality) in patients with ALI or ARDS by reducing systemic inflammation and the number of feeding complications as ..