Roeger's deep ball followed Buddy Reed and Casey McElroy hitting back-to-back home runs in the fifth as Canberra took a one-run lead.

It continued a see-sawing contest.

Adelaide reeled off three-straight doubles to take a 3-2 lead after the Cavs struck first with two first-inning runs.

But Witherspoon delivered the lead for good in his home debut.

Canberra piled on five eighth-inning runs on the back of his go-ahead shot after Brebner-Russ hit back-to-back hitters with the bases loaded and Tim Day issued a walk with runners everywhere on the basepaths.

Roeger and Bas Nooij hit late home runs for the Bite, while Jay Baum added a two-run bomb for the Cavs.

Adelaide's Rodrigo Ayarza picked up four hits - falling a home run short of the cycle - and David Kandilas went 3-for-5 for the hosts.

Grening worked seven innings, allowing five runs on eight hits and striking out five while picking up his fourth win.

Bite starter Greg Mosel allowed three earned runs on nine hits.

The series continues at 7pm on Friday with Frank Gailey set to start for Canberra against Ryo Koura.