Greetings to all! I have a question that perhaps someone out
there can answer. I am proposing as a possible Pre-lim topic the
study of the role of B cells in IBD (inflammatory bowel disease).
An advantage, which is also a disadvantage, is the lack of
information on this topic in the literature. I was curious if
anyone knew of pertinent data relating to this subject that might
not be easily obtained or hasn't been published. I have performed
multiple Medline searches and scanned issues of Gastroenterology
and Digestive diseases and Science for articles but haven't found
too many. I am also aware of the mouse models that have been
generated (i.e. IL-2 -/-, IL-10 -/-, TCR Mutant, C3H/HejBir) and
some of their possible uses.
My concerns are these: 1) someone has published beautiful
articles concerning this topic which I have missed 2) This topic has shown
to be a complete dead-end as they haven't any role whatsoever, according
to data by XXX et. al. (if you get my drift).... Opinions on the merit of
this topic as a pre-lim topic (which consists of a grant proposal) are
also welcome (of course, I've got to design all of my own experiments....)
Any thoughts are welcome. Thank-you for your time. My email
address is: friedr at med.unc.edu
-Randy
friedr at med.unc.edu