Abstract

Acquired Immunodeficiency Syndrome (AIDS) is one of the most critically acclaimed
endemic diseases, caused by two lentiviruses HIV-1 and 2. HIV-2 displays intimate
serological and antigenic resemblance to Simian Immunodeficiency Virus (SIV) along
with less pathogenicity, lower infectivity and appreciable cross reactivity with HIV-1
antigens. The present era is confronted with the challenge to fabricate a vaccine
effective against all clades of both the species of HIV. But vaccine development against
HIV-1 has proven highly intricate, moreover the laborious and deficient conventional
approaches has slackened the pace regarding the development of new vaccines. These
concerns may be tackled with the development of HIV-2 vaccine as a natural control
of HIV-1 that has been found in ancestors of HIV-2 i.e. African monkeys, mangabeys
and macaques. Thereby, suggesting the notion of cross protection among HIV-2 and HIV-1.
Assistance of bioinformatics along with vaccinomics strategy can bring about a quantum
leap in this direction for surpassing the bottleneck in conventional approaches. These
specifics together can add to our conception that HIV-2 vaccine design by in silico strategy will surely be a constructive approach for HIV-1 targeting.