Just got the latest build, SVN 4727. It fixed my sound and cutscenes but still stuttering game play it even crashed. Game play is especially slow in the beginning sequence and is better once in the little planets.

Well from my settings originally posted above, I just disabled panic handlers, disable progressive scan, disable EurGB60 Mode and disable overlay fps. Also enabled lock threads to core. And what really helped was using the frame skip option under the emulation tab. I set it to 9. Also let me remind you i put the resolution on 1920x1080. Depending on how you want to play you might want to put it to a lower resolution for a fps boost. make sure to turn down af and aa all the way down since i noticed that takes up a lot of resources.