The aim of this article was to assess the associations of serum 25-hydroxyvitamin D [25(OH)D] and daily sun exposure time with myopia in Korean adults.

This study is based on the Korea National Health and Nutrition Examination Survey (KNHANES) of Korean adults in 2010&ndash;2012; multiple logistic regression analyses were performed to examine the associations of serum 25(OH)D levels and daily sun exposure time with myopia, defined as spherical equivalent &le;&ndash;0.5D, after adjustment for age, sex, household income, body mass index (BMI), exercise, intraocular pressure (IOP), and education level. Also, multiple linear regression analyses were performed to examine the relationship between serum 25(OH)D levels with spherical equivalent after adjustment for daily sun exposure time in addition to the confounding factors above.

Between the nonmyopic and myopic groups, spherical equivalent, age, IOP, BMI, waist circumference, education level, household income, and area of residence differed significantly (all P&#8202;&lt;&#8202;0.05). Compared with subjects with daily sun exposure time &lt;2 hour, subjects with sun exposure time &ge;2 to &lt;5 hour, and those with sun exposure time &ge;5 hour had significantly less myopia (P&#8202;&lt;&#8202;0.001). In addition, compared with subjects were categorized into quartiles of serum 25(OH)D, the higher quartiles had gradually lower prevalences of myopia after adjustment for confounding factors (P&#8202;&lt;&#8202;0.001). In multiple linear regression analyses, spherical equivalent was significantly associated with serum 25(OH)D concentration after adjustment for confounding factors (P&#8202;=&#8202;0.002).

Low serum 25(OH)D levels and shorter daily sun exposure time may be independently associated with a high prevalence of myopia in Korean adults. These data suggest a direct role for vitamin D in the development of myopia.

Figure 2: The box and whisker plots of level of serum 25-hydroxyvitamin D [25(OH)D] according to the severity of myopia. The “box” is the interquartile range (IQR, 25th and 75th percentiles) with a notch to show the median. The whiskers show the 10th and 90th percentiles. Serum 25(OH) levels are shown according to the severity of myopia after adjustment for surveyed year, age, sex, household income, body mass index (BMI), exercise, education level, intraocular pressure (IOP), and daily sun exposure time (P for trend <0.001). D, diopter.

Mentions:
Serum 25(OH)D levels according to the severity of myopia are shown in Figure 2. The serum 25(OH) levels decreased significantly according to the severity of myopia after adjustment for survey year, age, sex, household income, BMI, exercise, education level, and daily sun exposure time (P for trend <0.001).

Figure 2: The box and whisker plots of level of serum 25-hydroxyvitamin D [25(OH)D] according to the severity of myopia. The “box” is the interquartile range (IQR, 25th and 75th percentiles) with a notch to show the median. The whiskers show the 10th and 90th percentiles. Serum 25(OH) levels are shown according to the severity of myopia after adjustment for surveyed year, age, sex, household income, body mass index (BMI), exercise, education level, intraocular pressure (IOP), and daily sun exposure time (P for trend <0.001). D, diopter.

Mentions:
Serum 25(OH)D levels according to the severity of myopia are shown in Figure 2. The serum 25(OH) levels decreased significantly according to the severity of myopia after adjustment for survey year, age, sex, household income, BMI, exercise, education level, and daily sun exposure time (P for trend <0.001).

The aim of this article was to assess the associations of serum 25-hydroxyvitamin D [25(OH)D] and daily sun exposure time with myopia in Korean adults.

This study is based on the Korea National Health and Nutrition Examination Survey (KNHANES) of Korean adults in 2010&ndash;2012; multiple logistic regression analyses were performed to examine the associations of serum 25(OH)D levels and daily sun exposure time with myopia, defined as spherical equivalent &le;&ndash;0.5D, after adjustment for age, sex, household income, body mass index (BMI), exercise, intraocular pressure (IOP), and education level. Also, multiple linear regression analyses were performed to examine the relationship between serum 25(OH)D levels with spherical equivalent after adjustment for daily sun exposure time in addition to the confounding factors above.

Between the nonmyopic and myopic groups, spherical equivalent, age, IOP, BMI, waist circumference, education level, household income, and area of residence differed significantly (all P&#8202;&lt;&#8202;0.05). Compared with subjects with daily sun exposure time &lt;2 hour, subjects with sun exposure time &ge;2 to &lt;5 hour, and those with sun exposure time &ge;5 hour had significantly less myopia (P&#8202;&lt;&#8202;0.001). In addition, compared with subjects were categorized into quartiles of serum 25(OH)D, the higher quartiles had gradually lower prevalences of myopia after adjustment for confounding factors (P&#8202;&lt;&#8202;0.001). In multiple linear regression analyses, spherical equivalent was significantly associated with serum 25(OH)D concentration after adjustment for confounding factors (P&#8202;=&#8202;0.002).

Low serum 25(OH)D levels and shorter daily sun exposure time may be independently associated with a high prevalence of myopia in Korean adults. These data suggest a direct role for vitamin D in the development of myopia.