I have for a few games. DOA5 comes to mind while waiting for a lobby match. I also use it for cheats! Needed to find Halo 4 terminals and I looked it up on the gamepad. I feel I am always using it, even if I am not playing games.

Also helpful in PC games so you don't have to tab out. Always freezes Borderlands...---I like video games. Go ahead, hate me for it.