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Abstract:

Open-access datasets for cardiac remodelling after myocardial infarction in any species have not been reported, and this limits the development of systems approaches in medicine. In this paper, we present a dataset from echocardio­graphic assessment of male C57BL mice that were subjected to acute myocar­dial infarction. We present measurements that show the deterioration of global left ventricular (LV) function, regional function, development of LV dila­tion and hypertrophy. At the same time, we present measurements showing the degree of cardiac injury as well as the development of pulmonary conges­tion. Importantly, LV dilation—a hallmark of cardiac remodelling—does not develop in all subjects, and this is only partly explained by the degree of car­diac injury.