Abstract: The easternmost sector of the Alta Floresta Gold Province, Amazon Craton, Brazil, hosts a significant number of disseminated, stockwork and vein-type gold deposits associated with paleoproterozoic plutonic-volcanic sequences, including the Luiz Au + base metals and the Paraíba and Pezão Au ± Cu vein-type deposits. Description of drill cores, petrography and U-Pb sensitive high-resolution ion microprobe (SHRIMP) IIe zircon geochronology allowed the characterization of the different geological attributes of these three deposits. At the Paraíba deposit the host lithotype is represented by biotite tonalite, whereas at the Luiz and Pezão deposits the host rocks encompass a biotite granodiorite intruded by a feldspar-porphyry and a syenogranite truncated by a quartz-porphyry, respectively. Metasomatic zones include chloritic, sericitic and potassic (biotite) alteration, and, outwards from the ore zones, carbonate infill, silicification plus quartz infill, potassic (K-feldspar) and propylitic alteration, besides post-mineralization quartz, carbonate, epidote, sericite and/or chlorite veinlets. The auriferous quartz veins in all deposits display massive texture, whereas barren quartz and/or quartz + carbonate veins at the Luiz and Pezão deposits commonly display open-space filling textures. Ore zones at Paraíba and Pezão deposits are represented by pyrite + chalcopyrite, whereas at Luiz deposit is characterized by pyrite + sphalerite + galena ± chalcopyrite. Fluid regime at the Paraíba ore zones encompasses aqueous-carbonic fluids, whereas at the Luiz and Pezão deposits are essentially characterized by low salinity two-phase aqueous fluids. U-Pb SHRIMP IIe zircon analysis of host rocks and Luiz feldspar-porphyry provided crystallization ages between 2,01 and 1,97 Ga. The evolution of the hydrothermal systems of these three deposits indicates a decrease in temperature and an increase in ¿O2 and pH of the fluid. Ore precipitation at the Paraíba deposit would be related to a combination of immiscibility process and fluid-rock interactions, while at the Luiz and Pezão deposits can be attributed to adiabatic expansion followed by boiling process. Data integration suggest that the Paraiba deposit may have originated at deeper crustal levels, whereas the Luiz and Pezão deposits would be positioned at shallower crustal levels. The close spatial relationship with granitic plutons suggests that the Paraíba, Pezão and Luiz deposits may be genetically linked to magmatic-hydrothermal systems, which developed as a result of the crystallization of sub-volcanic rocks (e.g. porphyries), considered as the possible source of fluids, heat and metals for these systems. In this context, the Paraíba deposit can be classified as an intrusion-hosted gold-quartz vein system, whereas the Luiz and Pezão deposits may represent mineralized systems similar to intermediate sulfidation polymettalic and low sulfidation gold-copper-bearing epithermal deposits, respectively. Although the mineralization ages are still unknown for these three deposits, the geological relationships between host and sub-volcanic rocks and ore zones, combined with geochronological data from this study and from literature, open the possibility that gold metallogeny within the province is not restricted to a single paleoproterozoic intrusive event (1.787 ± 3.2 to ± 1.786 1 Ma), but point to the possible existence of at least two mineralizing events (~ 1.78 and ~ 1.97 Ga). The U-Pb zircon geochronological data from this study suggest the correlation of the granitic rocks to the first magmatic event (1.98 to 1.97 Ga) in the easternmost portion of the province, or even an expansion of this age interval