IgA, IgA nephropathy, and IgA proteases

IgA nephropathy is a kidney disease that begins in early life and can cause progressive kidney damage. IgA are a form of antibodies that are present in healthy people but in patients with IgA
nephropathy they become “sticky” and therefore deposit in the kidneys. Over time, the kidneys become inflamed and scarred leading to kidney failure in some patients.