Invega

Invega is an antipsychotic medication very similar to Risperdal, another atypical antipsychotic marketed by Johnson & Johnson. Both drugs have been linked to a number of serious side effects, including gynecomastia in men and boys.

What is Invega Used For?

Invega (paliperidone) is an extended-release tablet approved to treat schizophrenia in adults and teenagers who are at least 12 years old. However, the medication is sometimes used “off-label” to treat other conditions, including ADHD, depression, and anxiety.

How Does Invega Work?

Invega affects various neurotransmitters in the brain, including dopamine and serotonin. Both are known to play a role in regulating mood and behavior. Schizophrenia is associated with the over-activity of dopamine. By blocking the brain’s dopamine receptors, Invega helps control schizophrenia.

Invega Side Effects

Patients treated with Invega should check with their doctor if they experience:

Chest pain

Cold sweats

Confusion

Cough

Difficulty with speaking

Difficulty with swallowing

Dizziness

Drooling

Excessive muscle tone

Fainting

Fast, pounding, or irregular heartbeat or pulse

Increase in body movements

Inability to move the eyes

Increased blinking or spasms of the eyelid

Increased blood pressure

Loss of balance control

Mask-like face

Muscle tension or tightness

Muscle trembling, jerking, or stiffness

Pain in the arms or legs

Restlessness

Shuffling walk

Slow heartbeat

Slowed movements

Slurred speech

Sticking out tongue when not meaning to

Stiffness of the limbs

Twisting movements of the body

Tic-like (jerky) movements of the head, face, mouth, and neck

Trembling and shaking of the fingers and hands

Tremors

Trouble with breathing, speaking, or swallowing

Uncontrolled movements, especially of the face, neck, and back

Uncontrolled twisting movements of the neck, trunk, arms, or legs

Unusual facial expressions

Unusual tiredness or weakness

Invega and Gynecomastia

Invega is an active metabolite of Risperdal. As such, it is associated with many of the same side effects, including gynecomastia (excessive male breast growth). It is thought that both Risperdal and Invega cause the pituitary gland to produce excessive levels of a hormone called prolactin. Prolactin is associated with breast development and milk production in females. High levels of prolactin can cause spontaneous lactation in women and can lead to gynecomastia, or excessive male breast growth, in men.

While gynecomastia is not life-threatening, it can be very embarrassing for it victims. In extreme cases, liposuction or even mastectomy may be required to remove excessive breast tissue caused by the condition.

Invega Black Box Warning

The Invega label includes a Black Box Warning that, among other things, cautions against its use in elderly dementia patients. The medication has never been approved to treat dementia-related psychosis, and may cause heart failure, sudden death, or pneumonia in this patient population.

Invega Settlement

In 2012, Johnson & Johnson struck an agreement with the U.S. Department of Justice to resolve illegal marketing charges involving Invega and other medications. Federal prosecutors alleged, among other things, that the company had marketed Invega for unapproved indications. The $2.2 billion agreement was one of the largest healthcare settlements in U.S. history.