All diseases have perturbation of the physiological redox status to some degree, which is described as oxidative stress – very redox-active metal complexes are best suited to restore physiological redox status;

Among metal complexes metalloporphyrin-based redox modulators, known as SOD-mimics, appeared to be the best suited to reduce oxidative stress injuries;

Different metalloporphyrins (metal = Mn, Fe, Zn, Co etc) have been designed, synthesized, and characterized, originally as SOD mimics;

Ability of Mn porphyrins to act as SOD mimics parallels their ability to rescue numerous diseases;