Although ACE Inhibitors and Angiotensin Receptor Blockers are effective blood pressure lowering agents, the exact mechanisms by which these agents lower BP are still not fully understood. This study aims to compare the blood pressure and hormonal responses (plasma renin activity and aldosterone) to the ACE inhibitor enalapril and ARB candesartan in individuals with mild essential hypertension.

Further study details as provided by St George's, University of London:

Primary Outcome Measures:

Change in BP

Change in PRA and aldosterone

Estimated Enrollment:

11

Study Start Date:

April 2004

Estimated Study Completion Date:

October 2006

Eligibility

Ages Eligible for Study:

18 Years to 70 Years

Genders Eligible for Study:

Both

Accepts Healthy Volunteers:

No

Criteria

Inclusion Criteria:

Essential Hypertension

SBP 140-159 mmHg

DBP 90-99 mmHg

Exclusion Criteria:

Intolerance of or allergy to ACE Inhibitors or ARBS

Pregnant or Breastfeeding

Pre-menopausal women

Uncontrolled cardiac or renal failure

Diabetes mellitus

Contacts and Locations

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study.
To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below.
For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00141583