NL Central

NL West

Kevin Youkilis, David Ortiz and Manny Ramirez homered one after the other in the sixth, but by then the damage was done as the Red Sox dropped their third straight in the series. Starter Tim Wakefield sailed until the fifth.

Paul Byrd put his stamp on Game 4 by keeping the Red Sox in check over five innings, and Casey Blake and Jhonny Peralta went deep to highlight a huge fifth inning as the Indians crept within one win of a spot in the World Series.