Monday, 10 May 2010

Now the Pentagon’s rolling out a revolutionary initiative to treat the condition: brain implants that one researcher likens to “replacement parts” for damaged gray matter.

“When something happens to the brain right now, there’s so little that the medical community can do,” Krishna Shenoy, associate professor of electrical engineering and bioengineering at Stanford University, told Danger Room. “Our goal is to understand — and then be able to change — how a brain responds to trauma.”

No surprise that military extreme science agency DARPA (Defence Advanced Research Projects Agency) is behind the project, which is called REPAIR, or Reorganization and Plasticity to Accelerate Injury Recovery. Yesterday, they announced an initial two-year round of $14.9 million in funding for four institutions, led by Stanford and Brown universities, that will collaborate on the brain-chip project. All in, it’ll involve 10 professors and their research teams, working in neuroscience, psychiatry, brain modeling and even semiconductors.

Significant progress has already been made in understanding brain injury. Scientists can create conceptual, mathematical models of brain activity, and are also able to record the electrical pulses emitted by individual neurons in the brain, which offers insight into how those neurons communicate. That knowledge has spurred rapid progress in neural-assisted prosthetic devices, a program that Shenoy collaborated on with Geoffrey Ling, the same Darpa program manager behind REPAIR.

The difficult thing is going to be decoding the sensory data from parts of the body below the break. But simple control of a prosthetic, that is at worst only a decade away.

Looks like in this one area, they've cracked it. Again, from Wired:

But what experts can’t yet do, Shenoy said, is alter those electrical pulses to turn brain circuits on or off. His team will use optogenetics, an emerging technique that involves emitting light pulses to precisely trigger neural activity, to develop an implanted TBI treatment device.

“Before this, emitting light into the brain would be like hitting it with a hammer,” Shenoy said. “What we’re doing now is pin-pointing a single neuron, and that neuron will naturally change its activity depending on the cue.”

The implants developed by the project will likely be composed of electrodes or optical fibers, and will sit on the surface of the brain. They’ll read electrical signals from neurons, and deliver appropriate light pulses to stimulate other brain regions in response. The implants would allow the brain to operate normally, by acting as substitutes for areas that were damaged or “unavailable.”

First up for Shenoy and company are optogenetic tests on mice, rats and eventually monkeys, to better understand how different regions of the brain interact. For example, how one area of the brain knows which signals to send to other parts. Once they’ve got that down, the researchers hope to develop chips that essentially mimic those interactions, so that an implant can “read a signal from region A, bypass damaged area B, and get that signal to C,” Shenoy said....If all goes according to plan, Shenoy expects implants for lab animals within four years

And ready for prime time a few years after that. About a decade all told. And some time after that, things rather more ambitious.

Some of possible pitfalls we'll have to look after are in this article here. Wherein I wrote:

Many brain injuries will now be, if not curable, treatable with "prosthetic brain segments" that will restore the cognitive deficits. Blindness may become extinct as artificial eyes coupled with artificial visual cortices will give sight to even the worst cases.

About Me

Actually, I am a Rocket Scientist.
Also hormonally odd (my blood has 46xy chromosomes anyway) and for most of my life, I looked male, and lived as one, trying to be the best Man a Gal could be. Anyway, in May 2005 that started changing naturally for reasons still unclear, and I'm now Zoe, not Alan : happier and more relaxed not to have to pretend any more.
UPDATE - reason now identified as the 3BHSD form of CAH.

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