These results indicate that ApoB (zeige APOB Antikörper) after lipidation is dislocated from the ER lumen to the LD surface for proteasomal degradation and that Derlin-1 (zeige DERL1 Antikörper) and UBXD8 are engaged in the predislocation and postdislocation steps, respectively.

These results suggest that Ubxd8 acts as a brake that limits triglyceride synthesis, and this brake is released when its structure is altered by exposure to unsaturated fatty acids.

The results indicate that although UBXD8 functionality can be largely compensated in the normal setting, it is crucial to sustain VLDL secretion when exposed to a dietary challenge of high fat.

Depletion of UBXD8 in hepatocytes suppresses VLDL secretion, and could lead to periportal steatosis when mice are fed a high-fat diet.

Fas Associated Factor Family Member 2 (FAF2) Antigen-Profil

Protein Überblick

The protein encoded by this gene is highly expressed in peripheral blood of patients with atopic dermatitis (AD), compared to normal individuals. It may play a role in regulating the resistance to apoptosis that is observed in T cells and eosinophils of AD patients.