Brain circuit differences reflect divisions in social status

Sep 02, 2014

Life at opposite ends of primate social hierarchies is linked to specific brain networks, a new Oxford University study has shown.

The importance of social rank is something we all learn at an early age. In non-human primates, social dominance influences access to food and mates. In humans, social hierarchies influence our performance everywhere from school to the workplace and have a direct influence on our well-being and mental health. Life on the lowest rung can be stressful, but life at the top also requires careful acts of balancing and coalition forming. However, we know very little about the relationship between these social ranks and brain function.

The new research, conducted at the University of Oxford, reveals differences between individual primate's brains which depend on the their social status. The more dominant you are, the bigger some brain regions are. If your social position is more subordinate, other brain regions are bigger. Additionally, the way the brain regions interact with each other is also associated with social status. The pattern of results suggests that successful behaviour at each end of the social scale makes specialised demands of the brain.

The research, led by Dr MaryAnn Noonan of the Decision and Action Laboratory at the University of Oxford, determined the position of 25 macaque monkeys in their social hierarchy and then analysed non-invasive scans of their brains that had been collected as part of other ongoing University research programs. The findings, publishing September 2 in the open access journal PLOS Biology, show that brain regions in one neural circuit are larger in more dominant animals. The regions composing this circuit are the amygdala, raphe nucleus and hypothalamus. Previous research has shown that the amygdala is involved in learning, and processing social and emotional information. The raphe nucleus and hypothalamus are involved in controlling neurotransmitters and neurohormones, such as serotonin and oxytocin. The MRI scans also revealed that another circuit of brain regions, which collectively can be called the striatum, were found to be larger in more subordinate animals. The striatum is known to play a complex but important role in learning the value of our choices and actions.

The study also reports that the brain's activity, not just its structure, varies with position in the social hierarchy. The researchers found that the strength with which activity in some of these areas was coupled together was also related to social status. Collectively, these results mean that social status is not only reflected in the brain's hardware, it is also related to differences in the brain's software, or communication patterns.

Finally, the size of another set of brain regions correlated not only with social status but also with the size of the animal's social group. The macaque groups ranged in size between one and seven. The research showed that grey matter in regions involved in social cognition, such as the mid-superior temporal sulcus and rostral prefrontal cortex, correlated with both group size and social status. Previous research has shown that these regions are important for a variety of social behaviours, such as interpreting facial expressions or physical gestures, understanding the intentions of others and predicting their behaviour.

"This finding may reflect the fact that social status in macaques depends not only on the outcome of competitive social interactions but on social bonds formed that promote coalitions," says Matthew Rushworth, the head of the Decision and Action Laboratory in Oxford. "The correlation with social group size and social status suggests this set of brain regions may coordinate behaviour that bridges these two social variables".

The results suggest that just as animals assign value to environmental stimuli they may also assign values to themselves – 'self-values'. Social rank is likely to be an important determinant of such self-values. We already know that some of the brain regions identified in the current study track the value of objects in our environment and so may also play a key role in monitoring longer-term values associated with an individual's status.

The reasons behind the identified brain differences remain unclear, particularly whether they are present at birth or result from social differences. Dr Noonan said: "One possibility is that the demands of a life in a particular social position use certain brain regions more frequently and as a result those areas expand to step up to the task. Alternatively, it is possible that people born with brains organised in a particular way tend towards certain social positions. In all likelihood, both of these mechanisms will work together to produce behaviour appropriate for the social context".

Social status also changes over time and in different contexts. Dr Noonan added: "While we might be top-dog in one circle of friends, at work we might be more of a social climber. The fluidity of our social position and how our brains adapt our behavior to succeed in each context is the next exciting direction for this area of research."

Related Stories

New studies released today reveal links between social status and specific brain structures and activity, particularly in the context of social stress. The findings were presented at Neuroscience 2013, the annual meeting ...

By studying the injuries and aptitudes of Vietnam War veterans who suffered penetrating head wounds during the war, scientists are tackling—and beginning to answer—longstanding questions about how the brain works.

New research in the UK on rhesus macaque monkeys has found for the first time that if they live in larger groups they develop more gray matter in parts of the brain involved in processing information on social ...

Our own social status influences the way our brains respond to others of higher or lower rank, according to a new study reported online on April 28 in Current Biology. People of higher subjective socioeconomic status show g ...

A single dose of the hormone oxytocin, delivered via nasal spray, has been shown to enhance brain activity while processing social information in children with autism spectrum disorders, Yale School of Medicine ...

Recommended for you

While studying a ground-nesting bird population near El Reno, Okla., a University of Oklahoma-led research team found that stress during a severe weather outbreak of May 31, 2013, had manifested itself into malformations ...

(Phys.org)—A pair of researchers with Harvard University has uncovered one of the secrets behind pigeons' impressive flight abilities. In their paper published in Proceedings of the National Academy of ...

The International Society of Feline Medicine (ISFM), the veterinary division of International Cat Care, has convened an expert panel of veterinary clinicians and academics to produce practical guidance to ...

(Phys.org)—A trio of researchers has found that one species of flower is able to pick and choose when it comes to accepting pollen from a variety of pollinators. In their paper published in Proceedings of ...

"...brain regions in one neural circuit are larger in more dominant animals. The regions composing this circuit are the amygdala, raphe nucleus and hypothalamus. Previous research has shown that the amygdala is involved in learning, and processing social and emotional information. The raphe nucleus and hypothalamus are involved in controlling neurotransmitters and neurohormones, such as serotonin and oxytocin."

Does anyone else recognize that the epigenetic link to cell type differentiation in these brain cells is nutrient-dependent and controlled by nutrient stress and social stress via their effects on the gonadotropin releasing hormone (GnRH) neuronal system, which links the epigenetic landscape to the physical landscape of DNA in the organized genomes of all mammals?

Excerpt from my most recent comment: The nutrient-dependent epigenetic effects of olfactory/pheromonal input are manifested in the morphological and behavioral phenotypes of the honeybee model organisms, which links epigenetic cause and effect to hormones that alter hormone-organized and hormone-activated human behavior. How can people like Dean Whittington continue to participate here, when they know nothing about neuroscience?