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Table 1

Cases of invasive pneumococcal disease, underreporting rates, and numbers adjusted for underreporting among children <15 years of age, 4 European countries, 1996–2006*

Country/epidemiologic year

Total typed

Underreporting, %†

Total adjusted‡

Serotype

PCV7 types

NVT

1

7F

19A

Spain

1996–97

155

18

869

544

325

62

0

28

1997–98

179

19

919

590

329

41

15

5

1998–99

191

26

740

415

326

81

16

31

1999–00

211

30

713

463

250

88

7

20

2000–01

252

28

901

580

322

107

11

54

2001–02

301

30

1,014

613

401

91

3

44

2002–03

426

39

1,092

528

564

131

31

97

2003–04

434

45

959

433

526

106

22

128

2004–05

528

43

1,228

367

860

207

70

198

2005–06

493

42

1,185

288

896

312

74

168

Belgium

1996–97

160

44

363

225

138

34

7

11

1997–98

202

46

436

272

165

32

9

32

1998–99

185

55

339

179

159

31

7

29

1999–00

197

55

356

218

138

40

5

23

2000–01

256

56

455

293

162

52

11

32

2001–02

295

65

454

268

186

48

11

32

2002–03

370

75

497

283

214

66

15

42

2003–04

382

73

521

270

251

91

20

42

2004–05

437

76

578

315

263

103

22

45

2005–06

378

75

506

190

316

102

37

58

France

1996–97

258

33

773

547

226

52

0

40

1997–98

NA

NA

NA

NA

NA

NA

NA

NA

1998–99

NA

NA

NA

NA

NA

NA

NA

NA

1999–00

NA

NA

NA

NA

NA

NA

NA

NA

2000–01

NA

NA

NA

NA

NA

NA

NA

NA

2001–02

320

41

775

497

278

64

15

53

2002–03

399

46

864

531

333

92

32

87

2003–04

384

47

811

424

387

119

23

90

2004–05

438

54

806

359

447

159

41

71

2005–06

389

50

774

277

497

157

62

93

England and Wales

1996–97

378

60

630

315

315

45

13

13

1997–98

429

62

689

462

226

43

14

26

1998–99

438

67

654

473

181

24

10

16

1999–00

429

64

666

453

213

36

8

37

2000–01

518

71

735

562

173

37

23

21

2001–02

557

72

770

549

221

37

14

28

2002–03

541

67

804

579

224

37

24

30

2003–04

627

71

889

628

261

67

16

37

2004–05

672

74

914

590

324

114

20

39

2005–06

775

76

1,014

640

374

139

38

38

*PCV7, heptavalent pneumococcal conjugate vaccine; PCV7 types, serotypes 4, 6B, 9V, 14, 18C, 19F, and 23F; NVT, non-PCV7 vaccine serotypes, i.e., serotypes not included in the PCV7 vaccine; NA, not available.†Underreporting rate = number of cases for which an isolate was typed at the national reference laboratory on the total number of laboratory-confirmed invasive pneumococcal cases estimated in the country (by capture–recapture or other methods) in children <15 years of age.‡The sum of PCV7 types and NVT cases may slightly differ from the total adjusted because of rounding.§Data have been adjusted for ascertainment and for the distribution of blood/cerebrospinal fluid isolates.

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