In this thesis, we consider the problem of fast and e&#64259;cient indexing techniques for time sequences which evolve on manifold-valued spaces. Using manifolds is a convenient way to work with complex features that often do not live in Euclidean spaces. However, computing standard notions of geodesic distance, mean etc. can get very involved due to the underlying non-linearity associated with the space. As a result a complex task such as manifold sequence matching would require very large number of computations making it hard to use in practice. We believe that one can device smart approximation algorithms for several classes of such problems which take into account the geometry of the manifold and maintain the favorable properties of the exact approach. This problem has several applications in areas of human activity discovery and recognition, where several features and representations are naturally studied in a non-Euclidean setting. We propose a novel solution to the problem of indexing manifold-valued sequences by proposing an intrinsic approach to map sequences to a symbolic representation. This is shown to enable the deployment of fast and accurate algorithms for activity recognition, motif discovery, and anomaly detection. Toward this end, we present generalizations of key concepts of piece-wise aggregation and symbolic approximation for the case of non-Euclidean manifolds. Experiments show that one can replace expensive geodesic computations with much faster symbolic computations with little loss of accuracy in activity recognition and discovery applications. The proposed methods are ideally suited for real-time systems and resource constrained scenarios.... (more)