Sertraline hydrochloride form II

Abstract: A second polymorph of sertraline hydrochloride {systematic name: [(1S-cis)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthy]methylammonium chloride}, a potent antidepressant drug, C17H18Cl2N+·Cl-, crystallizes in the same orthorhombic space group as form I. The molecules in both forms exhibit nearly identical bond distances and angles, but some aspects of the molecular conformation are significantly different. Hydrogen bonds involving N atoms and Cl- anions form chains in both forms.