VMware ESX supports boot from SAN. Booting from SAN requires one dedicated LUN per server.

VMware ESXi may be booted from SAN. This is supported for Fibre Channel SAN, as well as iSCSI and FCoE for certain storage adapters that have been qualified for this capability. Please check the Hardware Compatibility List for supported storage adapters.

I've not done any boot from SAN installation for quite some time, due to the cost of Fibre Channel and SAN storage, in favour of installing ESXi on USB and SD cards in supported servers.

Setup guides take you through installation on different storage platforms.

If your SAN happens to be on the HCL then I guess you could, but usually they are just used as shared storage between a number of Virtual host servers which have the computing power to run a number of virtual machines.

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