Researchers found that while acute-on-chronic liver failure prevalence decreased over a 10-year period, overall survival of patients with grade 3 acute-on-chronic liver failure did not improve, according to data published in Journal of Hepatology.“Studies show that the number of organ failures — used to define the stage of disease — is the strongest predictor of short-term mortality in ACLF,” Ruben Hernaez, MD, MPH, PhD, from the Michael E. DeBakey Veterans Affairs Medical Center in Texas, and colleagues wrote. “Other factors, including patient demographics,