Skype provides a great interface to chat with friends (Voice chat & Video Chat), and make cheap phone calls as well. The application needs to be installed in your desktop computer or laptop. That means you can access Skype account only from your computer. But now, you can use it on the go or from wherever you are. You can actually make Skype portable by running it from your USB Flash Drive.

Mark from MakeUseOf, explains it with very simple instructions. Skype doesn't officially offer a portable version of their app, but by moving the application to your flash drive/thumb drive and creating a data folder for Skype on that drive with a few simple tweaks, Skype runs smoothly and in portable style.