Anterior Cingulate Cortex and Hippocampal Volumes in Depressed Youths

By AnalyzeDirect Staff, last updated March 17, 2016

Major depression disorder is a mental health condition in which unrelenting feelings such as sadness, hopelessness, anger, or frustration persist for prolonged periods of time and interfere with a person’s daily life. Although major depression arises most commonly in early adulthood, anyone can develop major depression disorder, including children and teenagers.

While depression has been intensively studied in adults, the nature and the effects of this condition in younger subjects have been under-explored. In fact, whether youths with depression exhibit similar regional brain structural changes as those reported in adults is a question that remains to be addressed.

From brain MRI scans, Analyze software was used to measure left and right hippocampal volumes and subgenual anterior cingulate cortex volumes. These brain regions have been shown to play an essential role in the limbic system and in modulating aspects of emotional processing, respectively. Reductions in their volumes have been observed in depressed adults.

The team found that young participants with depression had smaller hippocampal volumes compared to matched healthy controls. Interestingly, older depressed subjects showed smaller volumes than younger patients. Inconsistent with the adult literature, they found that young depressed participants presented no difference in subgenual anterior cingulate cortex volumes compared to controls. However, the findings showed, for the first time, smaller subgenual anterior cingulate cortex volumes in depressed youths with a comorbid anxiety disorder.

Results from this study provide us with novel, valuable information regarding depression in youths and highlight the crucial role of altered neurodevelopment in the onset of this disorder.