Stanford Neurosurgery Research

The Department of Neurosurgery is a world leader in the fast-paced environment of innovative research translation. The rich intellectual environment at Stanford, paired with our accessibility to the most advanced technology, is unmatched and ensures the rapid translation of pioneering laboratory research into life-saving clinical therapies for our patients.

From anti-cancer therapies and stem cell transplantation therapies for spinal cord injury to the elucidation of retinal neural circuitry and gene-environment interactions in fetal development, our research scientists are making quick progress tackling some of the most complex neurological disease questions in the neurodegenerative and neuroregenerative fields today.

Our Department supports over 30 active labs investigating everything from brain injury, deep brain stimulation, brain tumors, epilepsy, pathophysiology and treatment of acute stroke, to the effects of stress and aging on the nervous system. And, although our research themes vary from lab to lab, they are all focused on aspects of disease and injury that can be investigated at the bench – and they all have clear implications for practices in the clinic and operating room.

Research Highlights

The efficacy of mild hypothermia in treating stroke is a vivid example of a laboratory-clinic connectionthat Stanford Neurosurgery faculty and collaborators find mutually beneficial. Hypothermia gained increasing acceptance in the 1990's when it was discovered that reducing body temperature by only a few degrees protected the brain from damage and improved treatment outcomes. Laboratory models of stroke may be used to determine the conditions that maximize the beneficial effects of hypothermia, and provide a window into the intra- and inter-cellular mechanisms underlying stroke damage. Promising therapies are suggested by and explored with laboratory research, and some of these therapies, such as mild hypothermia, are then tested in the clinic. It is fundamental to our mission to maintain and strengthen the laboratory-clinic connection.

Much of the damage to the brain caused by stroke is due to the generation of “radical oxygen species” which initiate processes leading to neuron damage and death. In a massive collaborative effort by Neurosurgery scientists and researchers in Biological Sciences, Neurology, and Anesthesiology, we have found that endogenous antioxidants can counteract much of this oxidative damage. This research program has succeeded in part because a number of powerful neurobiological methods have been brought to bear on the problem. Mice and rats that over- or under-express antioxidant proteins (methods pioneered by our Director of Neurosurgical Research, Dr. Pak H. Chan), gene therapy designed to enhance antioxidant function of neurons (in collaboration with Dr. Robert Sapolsky in Biological Sciences), and a combination of whole-animal and cell-culture techniques (the latter aided by our collaboration with Dr. Rona Giffard in Anesthesiology) have allowed our Cerebrovascular Disease Research Group to greatly extend the science of stroke.

Our laboratories conduct laboratory and clinical research to determine whether stem cells isolated from human brain tissue can survive and become functional parts of a damaged brain, and ultimately lead to improved clinical outcomes.

“Stem Cell Research” is a far broader field than suggested by news reports that focus on ethical considerations involved in the use of stem cells derived from human embryos and fetuses. We study the process of “neurogenesis,” or the brain's ability to grow new neurons. Such a process was long thought to be absent in the brain, but research in the last decade, much of it by Stanford Neurosurgery researchers, has shown neurogenesis to be robust and important to brain function and perhaps to the repair of the brain after injury.

Featured Publications

A team of Stanford researchers, including Lu Chen, PhD, Professor of Neurosurgery, published a new study suggesting that reactivation of retinoic acid signaling might be a beneficial therapeutic strategy for fragile X syndrome.

This computational study compares acute effects and long-lasting effects of six different spatio-temporally patterned stimulation protocols, including three variants of CR, using a no-stimulation condition as additional control.

Stanford Neurosurgeons have identified a signature pattern of electrical activity in a small, deep-brain region just a second or two before a burst of impulsive behavior. The findings could lead to less invasive methods of countering obesity, substance-abuse disorders, pathological gambling, sexual addiction or intermittent explosive disorder.

Parkinson's Disease Seed Grant

The Departments of Neurosurgery and Pathology are requesting applications for a Seed Grant Program to foster novel research in the area of basic, translational or clinical research related to Parkinson’s Disease. Funding will be up to $200,000 over 2 years. Open to Stanford faculty with UTL, MCL, NTLR and CE faculty appointments.