Introduction: Coping ways with stress in coronary heart disease patients can lead to significant changes in levels of Cardiac Biomarker Troponin I, but researchers had not explored it empirically. So, the main objective of this study was to identify the relationship between coping ways with stress and Cardiac Biomarker Troponin I and also, finding coping ways that predict changes in the concentration of the cardiac Troponin I. Methods: All CHD patients who referred to Tehran Shahid Rajaie Heart Hospital were target population. 44 patients with CHD admitted to different parts of hospital were selected among eligible patients. In this study, Lazarus coping ways questionnaire- and Troponin I (BioMerieux, Marcy L’Etoil, France) kit was used. Results: The results showed no positive and significant correlation between Emotional Focused Coping Ways (Inefficient) and Cardiac Biomarker Troponin I and also negative and significant correlation between Problem Focused Coping Ways (Efficient) and Cardiac Biomarker Troponin I. Coefficient of positive re-evaluation coping way (β=-0.735) according to the T test indicate that among 8 of coping ways only this variable with 99% confidence can predic the changes related to Cardiac Biomarker Troponin I. Conclusion: In total, we concluded that increase of application in Emotional Focused Coping Ways (Inefficient) lead to increase in levels of Cardiac Biomarker Troponin I and increase of application in problem focused Coping Ways (Efficient) lead to decrease in levels of Cardiac Biomarker Troponin I.