King of Cable Management

I use that layout currently but if you get a much longer riser cable (300mm) and route it under the motherboard (so GPU is on right side of board) then you can have both CPU and GPU oriented up and do not need high case feet.

Shrink Way Wielder

The advantage is having vents only on one side of the case, so in a horizontal position you wouldn't need case feet to prevent one side of the case from not getting any fresh air. This is also similar to the S3 mini layout except their GPU is on the other side of the motherboard.

You bring up a good point about m.2 hard drives beneath the motherboard. I don't know how hot the fastest drives would get but it's a good idea to test. I have a Sandisk X110 SATA drive beneath the motherboard, no venting at the bottom. It's usually about 45C to 50C warm.

Airflow Optimizer

I finally made an account here just so I could vote in this poll. I'm loving the idea/design of this case. It reminds me a lot of the S4 Mini but I would be super excited to see the cpu and gpu face up to show off all my tech goodness (and hide the ugly bare PCB). Looking forward to the renders this week and pricing in the future.