3

And with that......:
It's difficult to become toxic on a water soluble vitamin when your body can flush out the excess easily in the urine. If someone is genuinely b6 toxic, the solution is to stop taking massive doses of b6 before the problem becomes permanent.
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4

Depends:
Vitamin b6, when taken usual therapeutic dose, is not toxic. It can cause significant adverse effects, however, if you take too much of it for a prolonged period. Depending upon the amount of vitamin B6 ingestion, toxicity ranges from nausea to dependence or permanent peripheral neuropathy.
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6

B6 toxicity is well recognized:
There are a few questions that need to be asked in this case. Exactly how much B6 was the patient taking? According to recommended standards 200mg daily is the limit. Toxicity is thought to occur at levels of 1000mg. daily and above though much lower have been reported on rare occasions(100-300mg). Secondly, what exactly was the quality of her pain? Described symptoms of neural toxicity involves sensory neuropathy described mainly as burning dysesthesias and numbness. The case talks about a RADICULOPATHY. That is typically not the same type of pain as we find in chemical toxicities. Pain in the feet could very well be dysesthesias but the history could be a bit more specific there in order to attach more positive points for B6 sequelae.
http://www.ncbi.nlm.nih.gov/pubmed/16320662
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8

B6:
For adults with B6 deficiency, start with 2.5mg. to 25mg. daily for 3 weeks, then maintenance dose of 1.5-2.5 mg. per day. For women on Birth control pills, use 25mg. per day. For PMS , use 50-100mg. per day.
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9

From excessive doses:
In general, vitamin b6 is extremely safe and well-tolerated, though it may cause stomach upset in some (esp. If taken without food.However, taking high doses of b6 daily for months (usually at least 1000 mg but in some as low as 200 mg) can cause toxicity symptoms, most commonly peripheral neuropathy (tingling & numbness) also headaches, fatigue & irritability, which will dissipate upon stopping b6.
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