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the present invention relates to modified tetracycline repressor proteins that exhibit a “reverse” phenotype in prokaryotic organisms, nucleic acids encoding these repressor proteins, methods for identifying and preparing these proteins, and methods for using these proteins for regulating gene expression in prokaryotic organisms, in drug screening assays and for identifying non-antibiotic compounds that are specific inducers of these modified repressor proteins. On examination his temperature is 38.9°C (102.0°F), and he is awake, interactive, and consolable, with obvious otitis media of the left ear.

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