My research is focused on complement-mediated inflammatory, autoimmune and thrombotic microagiopathic disorders. By creating gene targeted mice, we establish mouse models of human diseases to understand disease pathogenesis and to test novel anti-complement therapies. We are also interested in the interaction of complement with other innate immune pathways such as the Toll-like receptors and with the adaptive immune system. Our long term goal is to advance basic complement immunology and to help develop new therapies for complement-mediated human diseases.