ABSTRACT: One hundred leprosy cases of different types have been studied for detection of rheumatoid factor, ASO antibodies and C-RP compared to 50 normal individuals in the same age range residing in the same locality. The test cases consisted of tuberculoid type-50, indeterminate type-15, border line tuberculoid-20, borderline lepromatous -6 and lepromatous types-9 only. Sex distribution was male-75 and female-25. Age range varied from 15 to 45 yrs. Incidence of positivity for rheumatoid factor, ASO antibody and C-reactive protein was 11 percent 4 percent and 5 percent respectively in leprosy whereas the control standard individuals showed presence of rheumatoid factor and C-RP lepromatous only in 2 percent each. Of different forms of leprosy, cases showed the highest incidence as 33 percent, 11 percent and 44 percent respectively of rheumatoid factor, ASO antibody and C-RP.