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1. A family of small secreted proteins of the C-lectin type that are implicated in regeneration, proliferation, and differentiation of the pancreas, liver, and gastrointestinal mucosa. Reg1 (lithostathine, pancreatic stone protein, 166 aa) is the product of the REG1 gene (regenerating gene 1) and is a mitogen for pancreatic islet cells. Reg3β (HIP/PAP1) is a Schwann cell mitogen (175 aa) produced by motor and sensory neurons during development.