(BETHESDA, MD) -- Polycystic ovary syndrome (PCOS) occurs when ovarian cysts block a woman's normal ovulation and menstrual cycle. While the problem sounds straightforward, the disease is complex, born from both multiple genetic components and environmental factors. PCOS affects up to five percent of the female population, and those diagnosed with the disease have a 2- to 7-fold risk of developing type 2 diabetes mellitus (T2DM). For this reason researchers believe a gene related to diabetes may also play a role in the onset of PCOS. A new study of 146 PCOS patients has found that the "diabetes gene" (calpain-10 (CAPN10)) is in fact an interesting candidate for explaining the syndrome.

Their study appears in the online edition of the American Journal of Physiology-Endocrinology and Metabolism (http://ajpendo.physiology.org). The journal is one of the 14 scientific publications published by the American Physiological Society (APS) (www.The-APS.org) each month.

Methodology

The study comprised 752 females. Of the total, 146 were diagnosed with PCOS and 606 were unrel'"/>

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