His first book was his autobiography, A Mother's Disgrace, which was published in 1994 by HarperCollins. Manuscripts concerning A Mother's Disgrace are in the Mitchell Library of the State Library of New South Wales. The manuscript was written in French, and the book concerns his journey to an alternative sexuality after twelve years of marriage and his meeting with his birth mother Yvonne. It was made into a screenplay by Ross Wilson in 1999. He never met his birth father, who was killed in an air crash shortly after the end of World War II.

His first fictional work, the epistolary novelNight Letters, was published in 1996. It was translated into German, French, Italian, Dutch, Finnish, Polish, and Portuguese.

His second novel was Corfu, published in 2001.

Dessaix's latest long work, Twilight of Love: Travels with Turgenev defies genre characterisation, interweaving a personal travelogue with a biography of Ivan Turgenev. It was published in 2004. It takes inspiration from his doctoral thesis on Turgenev and the Soviet Union, as well as Alain de Botton's works on travel, art and philosophy.

In March 2010 it was revealed that Dessaix had been refused a visa to attend the Shanghai International Literary Festival. He had declared his HIV-positive status on his application, and although the guidelines stated that HIV status would have no prejudicial effect, it was felt that it must have been the reason for the refusal because Dessaix had had no political involvement in matters concerning China.[1]

The State Library of NSW holds an extensive collection of material related to Dessaix including his papers concerning the writing of Night Letters.[2]