HICA

I have been doing some reading on this and I get a lot of mixed reviews. I have read back a few years and noticed Coop has been hot and cold. I understand that has a lot to do with what was available and when, data wise. I bought a bunch of Amino IV's as the price was too good, and I have some alpamine I have not started. Do I get a sufficient dose running these products? and do we know of any advantages over Leucine? as that seems to be the question going back and fourth.

Superior for retaining muscle while dieting. Proven effective in clinical trials unlike its less reliable cousin HMB. This is the metabolite of leucine that will give you the most bang for your buck, without the insulin spike you would get from an equivalent (5g + recommended) dose of leucine.

Most effective in a caloric deficit or while fasted.

I retain muscle better using Alphamine over other fat burners I have tried, which is quite a few, so I am a responder/believer in the effects of HICA.

Love its inclusion in AminoIV.

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I have been doing some reading on this and I get a lot of mixed reviews. I have read back a few years and noticed Coop has been hot and cold. I understand that has a lot to do with what was available and when, data wise. I bought a bunch of Amino IV's as the price was too good, and I have some alpamine I have not started. Do I get a sufficient dose running these products? and do we know of any advantages over Leucine? as that seems to be the question going back and fourth.

Hica is an metabolite of leucine. When leucine is ingested - leucine -> KIC -> HICA

The idea of why leucine is more effective is because when leucine is ingested you get KIC and KIC increased BCAA oxidation via BCKDH enzyme. It is believed that by supplementing with just HICA you can circumvent the interaction with BCKDH and thus result in more available BCAA for more anabolism.

We need a study that investigates the interaction between the BCKDH enzyme and HICA in order to have a better understanding of what's going on. Or a study that compared HICA supplementation vs leucine supplementation in resistance trained athletes in order to determine superiority.

Superior for retaining muscle while dieting. Proven effective in clinical trials unlike its less reliable cousin HMB. This is the metabolite of leucine that will give you the most bang for your buck, without the insulin spike you would get from an equivalent (5g + recommended) dose of leucine.

Most effective in a caloric deficit or while fasted.

I retain muscle better using Alphamine over other fat burners I have tried, which is quite a few, so I am a responder/believer in the effects of HICA.

That is a big stretch to say that leucine increases insulin same as carbs. Absolutely not. The insulin spike is significant but not near as much as an equal carb dose. Additionally, carbohydrate induced insulin response is biphasic, with the stored insulin in the pancreas being released immediately and sometime after that, insulin is produced by the pancreas and keeps being produced until the glucose clears. This secondary release of insulin is actually the comparatively larger release. Amino acids like Leucine only cause the initial release of stored insulin, but there is no biphasic response, no sustained release. So in all actuality, insulin release in response to leucine is very different from carbohydrate. As far as glutamine & glycine restoring glycogen; they can through gluconeogenesis‚?¶ but not as well as carbohydrate. Carbohydrates from diet can get into the bloodstream at a rate of about 50g/hour I believe whereas the maxed out rate of gluconeogenesis is about 5g/hour. So no‚?¶ they don‚??t restore glycogen as fast

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Superior for retaining muscle while dieting. Proven effective in clinical trials unlike its less reliable cousin HMB. This is the metabolite of leucine that will give you the most bang for your buck, without the insulin spike you would get from an equivalent (5g + recommended) dose of leucine.

Most effective in a caloric deficit or while fasted.

I retain muscle better using Alphamine over other fat burners I have tried, which is quite a few, so I am a responder/believer in the effects of HICA.

Love its inclusion in AminoIV.

Absolutely agreed, HICA is on my short list of very worthwhile ingredients.

No thats not what he says. What he says is we really dont have enough information currently in order to determine superiority. HICA may be superior or it may not be.

Yes, it is inconclusive as whether or not hica is superior. So based on that, and also that there are only a few hica supplements available at a steep price, it would be wise to stick with leucine until more conclusive evidence presents itself.