Alachlor is an herbicide from the chloroacetanilide family. It is an odorless, white solid. The greatest use of alachlor is for control of annual grasses and broadleaf weeds in crops. It is the second most widely used herbicide in the United States.[1] Use of alachlor as a herbicide is banned in the European Union.[2]

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The largest use of alachlor is as a herbicide for control of annual grasses and broadleaf weeds in crops, primarily on corn, sorghum, and soybeans.[4] It is the second most widely used herbicide in the United States, with particularly heavy use on corn and soybeans in Illinois, Indiana, Iowa, Minnesota, Nebraska, Ohio and Wisconsin.[1]

It is most commonly available as microgranules containing 15% active ingredients (AI), or emulsifiable concentrate containing 480 g/ litre of AI. Homologuation in Europe requires a maximum dose of 2,400 g per hectare of AI, or 5 litres/hectare of emulsifiable concentrate or 17 kg/ha of microgranules. The products are applied as either pre-drilling, soil incorporated or pre-emergence.[7]

The EPA cited the following long-term effects for exposures at levels above the MCL in drinking water exposed to runoff from herbicide used on row crops: slight skin and eye irritation; at lifetime exposure to levels above the MCL: potential damage to liver, kidney, spleen; lining of nose and eyelids; cancer. The major source of environmental release of alachlor is through its manufacture and use as a herbicide. Alachlor was detected in rural domestic well water by EPA's National Survey of Pesticides in Drinking Water Wells. EPA's Pesticides in Ground Water Database reports detections of alachlor in ground water at concentrations above the MCL in at least 15 U.S. states.[1]

Alachlor is a controlled substance under Australian law and is listed as a Schedule 7 (Dangerous Poison) substance. Access, use and storage are strictly controlled under state and territory law.[9] Since 2006, use of alachlor as a herbicide has been banned in the European Union.[2]

In "a judgment that could lend weight to other health claims against pesticides," in January, 2012 a French court found Monsanto, which manufactures Lasso, liable for chemical poisoning of a French farmer in 2004.[10] In 2015 a French appeals court upheld the ruling and ordered the company to "fully compensate" the grower.[11]

Alachlor exhibits moderate sorption in soil, ranging from 43-209 mL/g. Photodegradation is a minor contributor to alachlor fate. Degradation in soil appears to be largely biologically mediated, and produces multiple metabolites. The half life in aerobic soil ranges from about 6 to 15 days and is considerably shorter under anaerobic conditions.[12] One possible explanation for the short anaerobic half life is the observation that alachlor is rapidly transformed under anoxia to up to 14 degradation products in the presence of iron-bearing ferruginous smectites. The iron in such minerals can be used by certain soil bacteria as an electron acceptor when soils are flooded, thus the process of herbicide transformation by reduced clay is thought to be microbially mediated.[13] Similar observations have been reported for the herbicides trifluralin and atrazine.

Alachlor is often used in high school chemistry classrooms as a reactant in demonstrations such as the combustion of magnesium. Alachlor can be used as a substitution for methane gas in such an experiment when gas is not available.[14]