Mouth: mouthwashes; topical anesthetics are useful in reducing pain and allowing
the patient to take in fluids.

Management of underlying cause, including identifying and stopping any drug cause.

Treatment of secondary infection.

Some have advocated cyclophosphamide, plasmapheresis,
haemodialysis and immunoglobin therapy, but none of those should be considered
standard at this time.3
Immunoglobin therapy has shown the greatest success and is the most widely used.

The use of systemic
steroids is controversial. Some authors believe that they are contraindicated.
Treatment with systemic steroids has been associated with an increased prevalence
of complications.3

Complications

Gastrointestinal and respiratory involvement may progress to necrosis.

Skin: secondary infection and scarring.

Mucosal pseudomembrane formation may lead to mucosal scarring and loss of function
of the involved organ system.