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MI

MI 18SC:The Coming Influenza Pandemic

Examines the H1N1 influenza virus from molecular, clinical, societal, historical, demographic, economic, and political perspectives. Examines the unique genetic, epidemiological, virologic, and pathogenic features of the influenza virus that allow it to continue to reinvent itself and re-emerge on an annual basis. Discusses past successes and failures, the current status of influenza, and the critical factors to consider to avert the coming influenza pandemic. Explores whether or not the lessons learned from influenza can be applied to other diseases. Includes guest lectures, field trips, student presentations.

Terms: not given this year
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Units: 2
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Grading: Satisfactory/No Credit

MI 19SC:Measles and Sneezles and Things That Go Mumps in the Night

A study of measles (until recently one of the leading causes of death in the world and the most contagious disease agent ever studied) and its relatives in the paramyxovirus family, including mumps, respiratory syncytial virus, hendra, and nipah, as well as a number of important animal pathogens. Investigates the nature of viruses using the paramyxoviruses as a paradigm. Topics include: the history of this devastating group of pathogens; basic aspects of paramyxovirus taxonomy and molecular virology; viral epidemiology, emergence, and eradication, including the pioneering studies of Peter Panum; the use, misuse, and abuse of science; the interactions between pathogen and host and how this interplay leads to disease, including the appearance of a bizarre brain complication with 100% mortality; the politics and economics of infection; how a putative link between the measles vaccine and autism entered the public eye, and how it refuses to disappear despite overwhelming evidence to the contrary. Field trips, guest speakers, student presentations. No science background necessary.

Terms: not given this year
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Units: 2
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Grading: Satisfactory/No Credit

MI 70Q:Photographing Nature

Utilizes the idiom of photography to learn about nature, enhance observation, and explore scientific concepts. Builds upon the pioneering photographic work of Eadweard J. Muybridge on human and animal locomotion. A secondary goal is to learn the grammar, syntax, composition, and style of nature photography to enhance the use of this medium as a form of scientific communication and also to explore the themes of change across time and space. Scientific themes to be explored include: taxonomy, habitat preservation, climate change; species diversity; survival and reproductive strategies; ecological niches and coevolution, carrying capacity and sustainability, population densities, predation, and predator-prey relationships, open-space management, the physics of photography. Extensive use of field trips and class critque.

MI 104:Innate Immunology (IMMUNOL 204, MI 204)

Innate immune mechanisms as the only defenses used by the majority of multicellular organisms. Topics include Toll signaling, NK cells, complement, antimicrobial peptides, phagocytes, neuroimmunity, community responses to infection, and the role of native flora in immunity. How microbes induce and defeat innate immune reactions, including examples from vertebrates, invertebrates, and plants.

Terms: not given this year
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Units: 3
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Grading: Medical Option (Med-Ltr-CR/NC)

MI 115B:The Vaccine Revolution (HUMBIO 155B)

Advanced seminar. Human aspects of viral disease, focusing on recent discoveries in vaccine development and emerging infections. Journal club format: students choose articles from primary scientific literature, write formal summaries, and synthesize them into a literature review. Emphasis is on analysis, experimental design, and interpretation of data. Oral presentations. Enrollment limited to 8. Prerequisite: prior enrollment in
HumBio 155H Humans and Viruses or
MI 116, The Human Virosphere

Terms: not given this year
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Units: 6
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Grading: Letter (ABCD/NP)

MI 115C:Human Virology Inquiry Project

Advanced topics in human virology focusing on current issues in the field. Topics will include: clinical features of infection, epidemiology, molecular virology, drug development and policy, vaccinology, pathogenesis, host modulation, emerging infection, and media representations of viral infection. Student presentations and discussion in a small group setting. Prerequisite: prior consent of instructor.

MI 116:The Human Virosphere (MI 216)

Focus on interaction of humans and viruses from a number of perspectives: historical, cultural, political, and demographic. Organismal, molecular biological, biochemical, human and viral interactions; clinical aspects of viral disease, epidemiology and risk factors, public and international health, aspects of virology including emerging viruses and biological weapons. Case studies involving particular viruses: human herpes viruses, retroviruses, oncogenic viruses; vaccination and disease eradication, evolution of viruses as tools for research and therapy. Emphasis on general principles of biology and matters of decision making policy. Prerequisite: Biology core, Human Biology core, or consent of instructor.

Terms: not given this year
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Units: 5
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Grading: Medical Option (Med-Ltr-CR/NC)

MI 120:Bacteria in Health and Disease (BIO 120)

Enrollment limited to junior and senior undergraduates, graduate students and medical students. Introduces students to the bacteria that live in and on humans and, in some cases, can cause disease and sometimes death. Topics include the biology of the interaction of the simple microbe with complex human biology and the factors that determine whether or not we coexist relatively peacefully, suffer from overt disease, or succumb to the bacterial onslaught.

Terms: not given this year
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Units: 3
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Grading: Letter or Credit/No Credit