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In order to avoid the situation where two investigators study the same research question, please search our database to determine if your topic has already been studied. If you find that your topic or a related topic has already been submitted, you may wish to contact the investigator to inquire about his/her findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID # (e.g. DIAN-D1004), the full request has been submitted and is either approved, disapproved or in process.

Aim 3:Assess the influence of other risk factors (APOE, sex, etc.) on AD biomarkers trajectories in both populations

Investigator:Chengjie Xiong, PhD

Title:PreClinical Biomarker Signature RF1

Date of Request:11/4/2016

ID:DIAN-D1625

Aim 1:Integrate the biomarkers and clinical and cognitive databases from ACS+, AIBL, BIOCARD, and WRAP, and develop novel statistical methods for testing the ordering of all biomarkers, both cross-sectionally and longitudinally, to determine which biomarkers indicate the highest likelihood of preclinical

Aim 2:Statistically validate the preclinical stages of AD as proposed by the National Institute on Aging Alzheimer's Association (NIA-AA) Workgroup (Sperling et al. 2011) using data from ACS+, AIBL, BIOCARD, and WRAP, and quantify the amount of preclinical biomarker signature (PBS) through optimum weight

Aim 3:Optimize the design of modern randomized clinical trials (RCTs) in preclinical or early-stage AD by identifying the cognitive composite that minimizes the sample sizes required to adequately power such trials.