Use this section to discuss your experiences with prescription drugs, iron injections, and other medical interventions that involve the introduction of a drug or medicine into the body. Discuss side effects, successes, failures, published research, information about drug trials, and information about new medications being developed.

Important: Posts and information in this section are based on personal experiences and recommendations; they should not be considered a substitute for the advice of a healthcare provider.

I've been on bupropion for about 10 years. Occasionally I'll miss a dose or two and not really notice any decline in mood so I thought I'd try to get off it. I didn't take it for a few days (yes I know, not advisable w/o doctor supervision) and my mood pretty much stayed the same. However, my RLS symptoms really took off and it happened much earlier in the day. You know what's it like.

I didn't increase my pramipexole because I don't want to take more than 1mg at bedtime so the RLS was excruciating for a few days. I wondered if stopping the bupropion had anything to do with what was happening so I started taking it again. The RLS stopped quite dramatically (I'm still taking the pramipexole) with hardly any symptoms the last couple of days. I don't think the two events (stopping the bupropion then starting again with resulting RLS effects) are coincidental but I could be wrong. I'm very skeptical of some RLS solutions I've read about and somewhat so with what happened to me but gotta say something made a huge difference.

I've searched this board and found a few references to bupropion being helpful but also not helpful for RLS. Not consistent at all. I suppose the response to bupropion is an individual thing.

It is the first AD that the experts recommend because it can be helpful for some, neutral for most, and only very rarely causes RLS/WED to worsen. it isn't usually prescribed specifically for RLS/WED as it doesn't seem to be that effective for most people alone. But, as I understand it, it is the best first drug to try for depression if you have RLS.

It is mentioned on Buchfuhrer's website & in the little green book (2nd edition is blue) as possibly helping, because of its mild dopaminergic properties. The converse is mentioned too - that dopamine agonists can be effective against depression.