The initial codebase originated from IBM VisualAge. It is written mostly in Java. It can be used to develop applications in Java and, by means of various plug-ins, other programming languages including Ada, C, C++, COBOL, Fortran, Haskell, JavaScript, Perl, PHP, Python, R, Ruby (including Ruby on Rails framework), Scala, Clojure, Groovy, Scheme, and Erlang.

Eclipse can also be used to develop packages for the software Mathematica. Development environments include the Eclipse Java development tools (JDT) for Java and Scala, Eclipse CDT for C/C++ and Eclipse PDT for PHP, among others.