ABSTRACT:The scientific basis for the statement that plants and their active constituents play an important role in the prevention diseases is continuously advancing. In fact the origin of many therapeutic substances from the genus Wedelia. It is an interesting source of potential bioactive molecules, as iridoids compounds, flavonoids, diterpenoids derivatives, phytosteroids, with antioxidant, anti-inflammatory, antimicrobial, Hepatoprotective activity, analgesic and antihistamine ,Anti-implantation, antiasthmatic activities and anticancer activity. This work reviews the pharmacological evidence of extracts of plants from the genus Wedelia, giving an overview of the most studied biological effects and the known phytochemical composition. Although more studies are necessary, Wedelia exhibits proven potential to become of important pharmacological interest.