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The current study examined the individual and joint effects of the Big Five personality traits and acculturation on coping styles. Using the proposed framework of McCrae (2001), the relations among these variables were evaluated at the intracultural level to exploit previously unexplored within‐culture variability for an unstudied Asian American group (Korean Americans). This approach emphasizes the unique expression of specific personality traits in a single culture. A community sample of Korean Americans completed measures of the Five‐Factor Model of Personality (NEO‐PI‐R; Costa & McCrae, 1992), coping (Brief COPE; Carver, 1997), and acculturation (SL‐ASIA; Suinn, Ahuna, & Khoo, 1992). The results primarily showed statistically significant relations between the Big Five personality traits and coping. Neuroticism was positively related to indices of emotion‐focused coping (emotional support) and avoidance (substance abuse, behavioural disengagement, venting, self‐blame); Extraversion, Conscientiousness, and Openness were positively related to indices of problem‐focused (active coping, planning) and emotion‐focused coping (positive reframing, humour, acceptance); and Agreeableness was positively associated with active coping and humour. Acculturation was only significantly (and positively) associated with venting. Significant Acculturation×Big Five personality traits interactions were found, however. For individuals high in acculturation, both Neuroticism and Openness were positively related to indices of avoidance coping. Moreover, for individuals low in acculturation, a negative relationship was found between Conscientiousness and venting. These results show that there is considerable within‐culture variation for the dimensions of the Five‐Factor Model of Personality, coping styles, and acculturation in this largely bicultural sample. Moreover, the amount of variation and its directionality among the target study variables is similar to that typically found in Caucasian American samples. Finally, the stronger relations found between the dimensions of personality and coping styles (relative to the relations found between acculturation and coping styles) suggests that personality traits rather than acculturation may be more important clinically when profiling patients and developing treatment plans.