Which HIPS or Behavior Blocker can protect me from .SCR worms?

I use KIS for real-time protection, I know that Application Control(HIPS) can protect me from unsigned executable but what happens if a Malware with different format(.scr, .xml, .inf etc) runs and it couldn't detect by signatures or heuristic or even Behavior Blocker?

I need to know that KIS Application control can protect me or not? if not which HIPS or security program can do that and block unwanted worm like this?