For exact search enclose your search term with "quotation marks". Enter an "AND" between multiple search terms. Add an " * " behind your search term for full wildcard search.

Get in touch!

Our local employees are always happy to answer your questions. Highly trained and experienced teams in your country can provide quick, helpful, and comprehensive support.

Miltenyi Biotec distribution:

As a global market leader with numerous subsidiaries and distributors, Miltenyi Biotec is
committed to providing our customers around the world with the highest quality products.
In addition to direct selling in more than 20 countries in North America, Europe and
Asia/Pacific, Miltenyi Biotec also provides support for our customers through an
extensive distributor network covering dozens of additional countries.

As a global market leader with numerous subsidiaries and distributors, Miltenyi Biotec is
committed to providing our customers around the world with the highest quality products.
In addition to direct selling in more than 20 countries in North America, Europe and
Asia/Pacific, Miltenyi Biotec also provides support for our customers through an
extensive distributor network covering dozens of additional countries.

Cookie Settings

We use cookies in order to provide the best possible website experience for you.
This includes cookies that are technically required to ensure a proper functioning of the website,
as well as cookies which are used solely for anonymous statistical purposes,
for more comfortable website settings, or for displaying personalized content.
You are free to choose the categories you would like to permit. Please note that depending on your settings,
the full functionality of the website may no longer be available. Further information can be found in our Privacy Statement.

ODN 2006 is a B-class ODN for activation of B cells , induction of Il-6 secretion and activation of NF-kB-signalling pathways.

Detailed product information

Background information

TLR9 is a prominent member of the toll-like-receptor (TLR) family recognizing pathogen-associated molecular patterns. TLR9 recognizes specifically unmethylated CpG motifs in bacterial DNA leading to activation of immune cells

1

,

2

. These effects can be mimicked by short synthetical oligodeoxyribonucleotides (ODNs) containing unmethylated CpG motifs

3

.

Several classes of CpG ODN have been identified and can be distinguished by their effects on certain cell types. A-class ODNs containing 5’ and 3’ G-rich stretches induce high levels of type I IFN but show low activation of B cell proliferation. B-class ODNs activate B cells and TLR9-dependent NFkB signalling in recombinant cell lines but show low induction of IFN-α. C-class ODN induce high amounts of IFN-α and activate B cells. The recently discovered new P-Class ODNs show similar but superior properties to C-class ODNs.

Applications

B-class ODN for activation of B cells , induction of Il-6 secretion from human PBMCs, and activation of NF-kB-signalling pathways.

ODN 2006 is a B-class ODN for activation of B cells , induction of Il-6 secretion and activation of NF-kB-signalling pathways.

Detailed product information

Background information

TLR9 is a prominent member of the toll-like-receptor (TLR) family recognizing pathogen-associated molecular patterns. TLR9 recognizes specifically unmethylated CpG motifs in bacterial DNA leading to activation of immune cells

1

,

2

. These effects can be mimicked by short synthetical oligodeoxyribonucleotides (ODNs) containing unmethylated CpG motifs

3

.

Several classes of CpG ODN have been identified and can be distinguished by their effects on certain cell types. A-class ODNs containing 5’ and 3’ G-rich stretches induce high levels of type I IFN but show low activation of B cell proliferation. B-class ODNs activate B cells and TLR9-dependent NFkB signalling in recombinant cell lines but show low induction of IFN-α. C-class ODN induce high amounts of IFN-α and activate B cells. The recently discovered new P-Class ODNs show similar but superior properties to C-class ODNs.

Applications

B-class ODN for activation of B cells , induction of Il-6 secretion from human PBMCs, and activation of NF-kB-signalling pathways.