Why Topricin

GoBehind Topricin

GoBehindTopricin

Topricin Background

Topricin Background

Topricin topical medicines use alternative botanical and biologic formulations that are natural and safe, and have been distributed in the U.S. for 25 years. This topical medicine’s scientific mechanism of action is now postulated to include ion-channel effects, cellular signaling, and vascular tone, thereby reducing inflammation, encouraging wound-healing, and relieving neuromuscular pain.

Topricin topical medicines use alternative botanical and biologic formulations that are natural and safe, and have been distributed in the U.S. for 25 years. This topical medicine’s scientific mechanism of action is now postulated to include ion-channel effects, cellular signaling, and vascular tone, thereby reducing inflammation, encouraging wound-healing, and relieving neuromuscular pain.

The OTC topical medicine formulations in Topricin vary by product, but each contains combinations of natural botanicals and diluted natural venoms (see ingredients below). Topricin formulations are sold nationally in major and independent pharmacies, and grocery and natural stores, as well as major online marketplaces. To date, there are no reports of side effects, dependencies, toxicity, or other contraindications associated with Topricin topical medicine formulations.

The OTC topical medicine formulations in Topricin vary by product, but each contains combinations of natural botanicals and diluted natural venoms (see ingredients below). Topricin formulations are sold nationally in major and independent pharmacies, and grocery and natural stores, as well as major online marketplaces. To date, there are no reports of side effects, dependencies, toxicity, or other contraindications associated with Topricin topical medicine formulations.

Why Topricin

Why Topricin

Topricin formulations have been safely and widely used since 1994, and have received patents in the United States. Further, each Topricin product has received a unique NDC, or National Drug Code. The code is present on all nonprescription (OTC) and prescription medication packages and inserts in the U.S.

Topricin formulations have been safely and widely used since 1994, and have received patents in the United States. Further each Topricin product has received a unique NDC, or National Drug Code. The code is present on all nonprescription (OTC) and prescription medication packages and inserts in the U.S.

Clinical surveys to date of all Topricin topical formulations have demonstrated no untoward effects of the skin, circulatory system, or nervous system. Decades of actual usage further support Topricin’s safety in a broad population of pediatric and adult patients. These clinical surveys also demonstrate a statistically meaningful reduction of pain, based on questionnaires. Patients also reported their satisfaction with the topical product, because it was easy to apply, natural, odorless, non-staining, and moisturizing.

Clinical surveys to date of Topricin topical formulations have demonstrated no untoward effects of the skin, circulatory system, or nervous system. Decades of actual usage further support Topricin’s safety in a broad population of pediatric and adult patients. These clinical surveys also demonstrate a statistically meaningful reduction of pain, based on questionnaires. Patients also reported their satisfaction with the topical product, because it was easy to apply, natural, odorless, non-staining, and moisturizing.

The active ingredients, up to 17 natural bio-medicines, in Topricin are medically valuable and scientifically substantiated, with mechanisms of action that include effects upon ion-channels, coagulation, and vascular tone, thereby reducing inflammation, encouraging wound-healing, and relieving neuromuscular pain, as further discussed below.

The active ingredients, up to 17 natural bio-medicines, in Topricin are medically valuable and scientifically substantiated, with mechanisms of action that include effects upon ion-channels, coagulation, and vascular tone, thereby reducing inflammation, encouraging wound-healing, and relieving neuromuscular pain, as further discussed below.

Message From Topricin Co-Founder and Formulator Lou Paradise:

The Micro-Environment and the Skin:

Research for Topricin started by first recognizing the body’s miracle of healing. The analgesics model both taken internally and topically applied to mask symptoms never addresses the cause and effect that pain produces serious, sometimes deadly side effects, and shuts the healing process down. The body’s ability to heal itself is a beautiful, complex, elegant system, and without it, life as we know it could not exist. Many of the secrets of this vibrant mechanism are found in the micro-environment. The question when we first started developing Topricin was: could we configure a means to enhance and support the body’s intrinsic, natural ability to heal while addressing the cellular cause of joint, nerve and muscle pain?

The Skin and Homeostasis for the Entire Body:

The skin is the largest organ of the body responsible for: regulating body temperature; blood reserves; excreting toxic substances through perspiration; sensory organ for touch and emotional sensations; the production of hormones released in micro-circulation vital for important functions of the entire human organism such Vitamin D synthesis. Deeper research revealed the skin does not just have structures to store and release hormones, the chemical messenger powerhouses of the body, but more so the skin produces hormones and or hormone like compounds.

Homeopathy - the Elegant Medicine:

In the conventional approach to pain management, symptoms such as pain are perceived to be an extension of the condition. Chemical based medicines seek to inhibit, nullify or interfere with the body’s natural chemistries to reduce or eliminate the symptom. This sounds like a good idea on paper however when we do this we literally shut the healing process down, and by doing so take the body out of homeostasis. This increases the risks of medical conditions worse than the symptom while not adressing the cause of the original symptom.

Homeopathy as a practice is a comprehensive medical model, and its purpose is to help the body in an elegant gentle manner to heal and repair itself. The body’s powerful, yet subtle, molecular chemistries and Nano-currents, provide energy transfers, and optimum metabolic function, and only need subtle minor chemistry adjustments to maintain balance. The symptom from a homeopathic prospective is the guiding principle that aligns the remedy biomedicine needed to help the body restore this subtle vital balance so to naturally return to optimum healing, health, vitality and homeostasis.

How Does Topricin Work:

Topricin treats the skin to support the vital functions as mentioned above, including its regulation of all the healing chemistries the body needs and uses to set the stage for optimum healing of the cells deep in the site causing the pain. The combination of natural biomedicines (11-17) depending on the product goes down to the lymphatics to release any excess inflammatory fluid pressure restricting microcirculation. This action serves to detoxify and restore oxygen/nutrient rich blood flow to the cells effected.

Biomedicines:

Each of the biomedicines found in Topricin are molecular sized and nearly identical to the body’s own healing chemistry, so they easily pass through the skin to the pain site. The biomedicines are all safe and have a specific purpose. The specific combination of biomedicine compounds are needed to assist the body in order to balance its multiple chemistries and achieve homeostasis and optimum healing. All the biomedicines are sourced naturally: six from botanicals; one mineral that treats and optimize the skin; four biomedicines from reptile venoms. Venoms contain a host of extremely rich and complex natural sources of biologically active molecules including peptides and enzymes that have variety of molecular targets and functions. Micro-dosed homeopathically, they provide enzyme action that supports metabolic function and healing.

Message From Topricin Co-Founder and Formulator Lou Paradise:

The Micro-environment and the Skin:

Research for Topricin started by first recognizing the body’s miracle of healing. The analgesics model both taken internally and topically applied to mask symptoms never addresses the cause and effect that pain produces serious, sometimes deadly side effects, and shuts the healing process down. The body’s ability to heal itself is a beautiful, complex, elegant system, and without it, life as we know it could not exist. Many of the secrets of this vibrant mechanism are found in the micro-environment. The question when we first started developing Topricin was: could we configure a means to enhance and support the body’s intrinsic, natural ability to heal while addressing the cellular cause of joint, nerve and muscle pain?

The Micro-Environment and Microcirculation:

Research for Topricin started by first recognizing the body’s miracle of healing. The analgesics model both taken internally and topically applied to mask symptoms never addresses the cause and effect that pain produces serious, sometimes deadly side effects, and shuts the healing process down. The body’s ability to heal itself is a beautiful, complex, elegant system, and without it, life as we know it could not exist. Many of the secrets of this vibrant mechanism are found in the micro-environment. The question when we first started developing Topricin was: could we configure a means to enhance and support the body’s intrinsic, natural ability to heal while addressing the cellular cause of joint, nerve and muscle pain?

The Skin and Homeostasis for the Entire Body:

The skin is the largest organ of the body responsible for: regulating body temperature; blood reserves; excreting toxic substances through perspiration; sensory organ for touch and emotional sensations; the production of hormones released in micro-circulation vital for important functions of the entire human organism such Vitamin D synthesis. Deeper research revealed the skin does not just have structures to store and release hormones, the chemical messenger powerhouses of the body, but more so the skin produces hormones and or hormone like compounds.

Homeopathy - the Elegant Medicine:

In the conventional approach to pain management, symptoms such as pain are perceived to be an extension of the condition. Chemical based medicines seek to inhibit, nullify or interfere with the body’s natural chemistries to reduce or eliminate the symptom. This sounds like a good idea on paper however when we do this we literally shut the healing process down, and by doing so take the body out of homeostasis. This increases the risks of medical conditions worse than the symptom while not adressing the cause of the original symptom.

Homeopathy as a practice is a comprehensive medical model, and its purpose is to help the body in an elegant gentle manner to heal and repair itself. The body’s powerful, yet subtle, molecular chemistries and Nano-currents, provide energy transfers, and optimum metabolic function, and only need subtle minor chemistry adjustments to maintain balance. The symptom from a homeopathic prospective is the guiding principle that aligns the remedy biomedicine needed to help the body restore this subtle vital balance so to naturally return to optimum healing, health, vitality and homeostasis.

How Does Topricin Work:

Topricin treats the skin to support the vital functions as mentioned above, including its regulation of all the healing chemistries the body needs and uses to set the stage for optimum healing of the cells deep in the site causing the pain. The combination of natural biomedicines (11-17) depending on the product goes down to the lymphatics to release any excess inflammatory fluid pressure restricting microcirculation. This action serves to detoxify and restore oxygen/nutrient rich blood flow to the cells effected.

Biomedicines:

Each of the biomedicines found in Topricin are molecular sized and nearly identical to the body’s own healing chemistry, so they easily pass through the skin to the pain site. The biomedicines are all safe and have a specific purpose. The specific combination of biomedicine compounds are needed to assist the body in order to balance its multiple chemistries and achieve homeostasis and optimum healing. All the biomedicines are sourced naturally: six from botanicals; one mineral that treats and optimize the skin; four biomedicines from reptile venoms. Venoms contain a host of extremely rich and complex natural sources of biologically active molecules including peptides and enzymes that have variety of molecular targets and functions. Micro-dosed homeopathically, they provide enzyme action that supports metabolic function and healing.

Botanicals used in pain management

Botanicals used in pain management

Topricin topical formulations include bioactive botanicals with substantiated pain relief effects and complementary benefits, including Arnica, and Echinacea. The clinical or scientific benefits of bioactive botanicals have been shown for inflammatory skin conditions, skin care, and anti-inflammation for pain relief.

The Topricin base cream formulation (also see below), while not considered active ingredients, contains botanicals with other known benefits, such as moisturizing.

Topricin topical formulations include bioactive botanicals with substantiated pain relief effects and complementary benefits, including Arnica, and Echinacea. The clinical or scientific benefits of bioactive botanicals have been shown for inflammatory skin conditions, skin care, and anti-inflammation for pain relief.

The Topricin base cream formulation (also see below), while not considered active ingredients, contains botanicals with other known benefits, such as moisturizing.

Mechanism of Action of Venoms in Analgesia

Mechanism of Action of Venoms in Analgesia

The mechanism of action of venoms in analgesia continues to be widely studied for both neuropathic and inflammatory pain models. At present, Topricin topical formulations include four specific venoms in dilute form, with specific mechanisms postulated to include ion- and acid-sensing channel effects and other cellular signaling mechanisms, resulting in inflammatory and microcirculatory changes. These channel effects and cellular signaling mechanisms may improve vascular function and anti- inflammatory response, and have been identified for the development of pain management treatments.

The mechanism of action of venoms in analgesia continues to be widely studied for both neuropathic and inflammatory pain models. At present, Topricin topical formulations include four specific venoms in dilute form, with specific mechanisms postulated to include ion- and acid-sensing channel effects and other cellular signaling mechanisms, resulting in inflammatory and microcirculatory changes. These channel effects and cellular signaling mechanisms may improve vascular function and anti- inflammatory response, and have been identified for the development of pain management treatments.

Biologic nervous, and muscular systems venoms are aqueous solutions containing a mixture of mostly peptides and proteins (both enzymatic and non-enzymatic), and a single venom may contain several hundred biologically- active compounds. At present, some of these venom-derived medicines are commonly used, including the ACE-inhibitor Lisinopril for which approximately 104 million prescriptions in America were filled in 2014.

Biologic nervous, and muscular systems venoms are aqueous solutions containing a mixture of mostly peptides and proteins (both enzymatic and non-enzymatic), and a single venom may contain several hundred biologically- active compounds. At present, some of these venom-derived medicines are commonly used, including the ACE-inhibitor Lisinopril for which approximately 104 million prescriptions in America were filled in 2014.

Venom-based medicines have been used for therapeutic pain management, with increasing rates of publication and study for venom’s use in analgesics. This includes venom’s use in neuropathic pain management. Venoms have been used to treat pain in both dilute form as well as topical form, with clinical efficacy shown for muscle relaxant and analgesic topical properties.

Venom-based medicines have been used for therapeutic pain management, with increasing rates of publication and study for venom’s use in analgesics. This includes venom’s use in neuropathic pain management. Venoms have been used to treat pain in both dilute form as well as topical form, with clinical efficacy shown for muscle relaxant and analgesic topical properties.

Pain Management: A Growing Problem

Pain Management: A Growing Problem

Present-day treatment of pain has led to staggering morbidity and escalation of cost, economically and societally. In the U.S. alone, one hundred million Americans suffer chronic pain. Globally, body pain affects more than 88% of the population, with 65% of people experiencing body pain at least once a week, 69% of people enduring long-lasting pain, and 22% of pain sufferers reporting severe body pain. Of these sufferers, 86% admit that pain limits their general capacity and 67% feel it decreases their quality of life.

Present-day treatment of pain has led to staggering morbidity and escalation of cost, economically and societally. In the U.S. alone, one hundred million Americans suffer chronic pain. Globally, body pain affects more than 88% of the population, with 65% of people experiencing body pain at least once a week, 69% of people enduring long-lasting pain, and 22% of pain sufferers reporting severe body pain. Of these sufferers, 86% admit that pain limits their general capacity and 67% feel it decreases their quality of life.

Societal impact of pain

Societal impact of pain

Pain is a major disruptor of lives and economies. For children, there is an impact on school performance, attendance, and peer interaction. For adults, pain causes impairments in physical and psychological functioning. Often, there is a need for work modification or disability claims. As a result, people with pain have higher health care expenditures and lower socioeconomic status.

Pain is a major disruptor of lives and economies. For children, there is an impact on school performance, attendance, and peer interaction. For adults, pain causes impairments in physical and psychological functioning. Often, there is a need for work modification or disability claims. As a result, people with pain have higher health care expenditures and lower socioeconomic status.

Pain is complex, with physical, neurological, psychological, economical, and symbolic components. One out of every two people consider themselves vocal about their body pain, with 69% of people feeling their pain impacts their family, 64% of people feeling their pain impacts their love life, 72% of people feeling their pain impacts their social life, 78% of professionals feeling their pain impacts their work, and 71% of students feeling their pain impacts their studies.

Pain is complex, with physical, neurological, psychological, economical, and symbolic components. One out of every two people consider themselves vocal about their body pain, with 69% of people feeling their pain impacts their family, 64% of people feeling their pain impacts their love life, 72% of people feeling their pain impacts their social life, 78% of professionals feeling their pain impacts their work, and 71% of students feeling their pain impacts their studies.

Opioid abuse, Dependence, Impact

Opioid abuse, Dependence, Impact

The White House Council of Economic Advisors has estimated that in 2015, the economic cost of the opioid crisis was $504.0 billion, or 2.8% of GDP that year. The present opioid addiction and dependence epidemic in the United States is unique in that it is a result of medical- based prescribing, disproportionately affecting privately-insured white, middle-class individuals in non-urban settings.16 Remarkably, between 2007 and 2014, opioid dependence in privately- insured individuals rose by 3,203%. Over the same approximate timeframe, private insurance charges rose from $72 million to $722 million. Opioids killed more than 42,000 people in America in 2016, more than any previous year on record, with 40% of all opioid overdose deaths involving a prescription opioid.

The White House Council of Economic Advisors has estimated that in 2015, the economic cost of the opioid crisis was $504.0 billion, or 2.8% of GDP that year. The present opioid addiction and dependence epidemic in the United States is unique in that it is a result of medical- based prescribing, disproportionately affecting privately-insured white, middle-class individuals in non-urban settings.16 Remarkably, between 2007 and 2014, opioid dependence in privately- insured individuals rose by 3,203%. Over the same approximate timeframe, private insurance charges rose from $72 million to $722 million. Opioids killed more than 42,000 people in America in 2016, more than any previous year on record, with 40% of all opioid overdose deaths involving a prescription opioid.

Nonsteroidal and Acetaminophen Pharmacological Risks

Nonsteroidal and Acetaminophen Pharmacological Risks

Pharmacologic risks are not isolated to opioid use. The Arthritis, Rheumatism, and Aging Medical Information System (ARAMIS) has estimated that more than 100,000 hospitalizations and more than 16,000 deaths in the United States each year are due to NSAID-related complications, with costs greater than $2 billion. Concerns of hepatotoxicity risks and gastrointestinal-related events associated with NSAIDs require medical prescribers to evaluate risks and benefits for every patient. There is also significant cardiovascular risks for NSAIDs, with a Lancet meta-analysis of trials showing high doses of common NSAIDs increasing the risk of vascular events by a third.

Pharmacologic risks are not isolated to opioid use. The Arthritis, Rheumatism, and Aging Medical Information System (ARAMIS) has estimated that more than 100,000 hospitalizations and more than 16,000 deaths in the United States each year are due to NSAID-related complications, with costs greater than U.S. $2 billion. Concerns of hepatotoxicity risks and gastrointestinal-related events associated with NSAIDs require medical prescribers to evaluate risks and benefits for every patient. There is also significant cardiovascular risks for NSAIDs, with a Lancet meta-analysis of trials showing high doses of common NSAIDs increasing the risk of vascular events by a third.

Since its introduction in 1955, acetaminophen has become the most widely used analgesic in the United States. Worldwide, it is contained in hundreds of over-the-counter (OTC) and prescription medications.

Although safe at therapeutic doses, acetaminophen is the most common cause of acute liver failure in the United States, accounting for 50% of all reported cases and 20% of liver transplant cases. The American Association of Poison Control Centers (AAPCC) reports that acetaminophen is one of the most common pharmaceuticals associated with both intentional and unintentional poisoning and toxicity.

Since its introduction in 1955, acetaminophen has become the most widely used analgesic in the United States. Worldwide, it is contained in hundreds of over-the-counter (OTC) and prescription medications.

Although safe at therapeutic doses, acetaminophen is the most common cause of acute liver failure in the United States, accounting for 50% of all reported cases and 20% of liver transplant cases. The American Association of Poison Control Centers (AAPCC) reports that acetaminophen is one of the most common pharmaceuticals associated with both intentional and unintentional poisoning and toxicity.

Concerns of hepatotoxicity risks and gastrointestinal-related events associated with NSAIDs require medical prescribers to evaluate risks and benefits for every patient. There is also significant cardiovascular risks for NSAIDs, with a Lancet meta-analysis of trials showing high doses of common NSAIDs increasing the risk of vascular events by a third. Since its introduction in 1955, acetaminophen has become the most widely used analgesic in the United States. Worldwide, it is contained in hundreds of over-the-counter (OTC) and prescription medications. Although safe at therapeutic doses, acetaminophen is the most common cause of acute liver failure in the United States, accounting for 50% of all reported cases and 20% of liver transplant cases. The American Association of Poison Control Centers (AAPCC) reports that acetaminophen is one of the most common pharmaceuticals associated with both intentional and unintentional poisoning and toxicity.

Concerns of hepatotoxicity risks and gastrointestinal-related events associated with NSAIDs require medical prescribers to evaluate risks and benefits for every patient. There is also significant cardiovascular risks for NSAIDs, with a Lancet meta-analysis of trials showing high doses of common NSAIDs increasing the risk of vascular events by a third. Since its introduction in 1955, acetaminophen has become the most widely used analgesic in the United States. Worldwide, it is contained in hundreds of over-the-counter (OTC) and prescription medications. Although safe at therapeutic doses, acetaminophen is the most common cause of acute liver failure in the United States, accounting for 50% of all reported cases and 20% of liver transplant cases. The American Association of Poison Control Centers (AAPCC) reports that acetaminophen is one of the most common pharmaceuticals associated with both intentional and unintentional poisoning and toxicity.

Topricin Ingredients

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