Psychedelic use and teeth pain

For tooth pain, would it be safe to use a topical cream such as Orajel when taking LSD & 2cb?

Topical creams should not interact with psychedelics. But psychedelics can have an impact in pain and body sensations. It may diminish them, change them, increase them or give another significance. If you have ever been on psychedelics you know what I mean. I think this factor should be considered in your case. If possible, it is better to use psychedelics in the best physical state possible.