Investigation into Lupron Side Effects (Leuprolide Acetate)

Messages Sent So Far

The purpose of this petition is to warn others regarding the drug Lupron (Leupolide Acetate) mfg. by Takeda/Abbott Pharmaceuticals in the hope that further long-term safety studies are done before it disables or kills more women. This drug was originally marketed to treat prostate cancer patients but now is widely used for the treatment of endometriosis, infertility, fibroids/ovarian cysts and even precocious puberty.

Many women are continuing to suffer the side effects long after taking their last dose even though their doctor and the pharmaceutical company states that the side effects should go away within 3-6 months. Side effects include but are not limited to: hot flashes, memory loss, tachycardia, hematura, hypotension, dizziness, insomnia, anxiety, depression, Vitamin D deficiency, constant gnawing bone/joint pain, osteoarthritis, osteopenia, osteoporosis, fibromyalgia, degenerative disc disease, autoimmune diseases, blood disorders, cancer and many others including death and yet not one long term study has been conducted.

It is devastating to us that we agreed to take an FDA approved drug under the care of our physician whom we trusted only to find ourselves sicker than you could imagine ---- in pain and unable to get the proper treatment or even believed that Lupron caused our problems.

We hereby request that an investigation be undertaken into the short term and long term effects of Lupron on women. We further request that all outcomes and results of such trials be released and published so that both patients and doctors alike may have the benefit of all the information regarding this drug.

Public Comments

Feb 19th, 2017

Amtul
W.
from Avon, MA
writes:

Lupron ruined my life. I had no idea about lasting sidd effects innthe long term. I had to quit school and my job. I am disabled can no longer leave the house except for appointments, can no longer drive, amdI am in constant, debilitating pain and my endometriosis is worse than ever. I am also broke. My memory is shot. I am not the same person. My entire life is ruined. I will never has a house or a child. I am only 27.

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Feb 17th, 2017

Tonya
C.
from Patterson, LA
writes:

I took lupron for a year and I feel the side effects til this day. It has been ten years almost and I still feel even with a healthy lifestyle my body is fading away. My teeth, bones, health, hair, skin... Has never been the same.

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Feb 13th, 2017

Judith
B.
from Butler, GA
writes:

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Feb 12th, 2017

Alecia
W.
from Hamilton, OH
writes:

I took Lupron as a treatment for my endometriosis about 9 years ago. I had 9 doses given to me as monthly shots in my lower back/hip area. Since taking these shots my teeth have been badly disintegrating, I experience horrible hip pain someone's to the point that i can't walk, and my endometriosis has only gotten worse. It saddens me that a drug i took to alleviate my pain has only worsened it.

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Feb 7th, 2017

Someone
from Los Angeles, CA
signed.

Feb 7th, 2017

Becky
B.
from Butler, GA
writes:

I am a 79-year-old lady. My FIBROMYALGIA disease appeared at the age of 74, with no hope of a cure from the hospital i looked further for an alternative treatments, a friend of mine told me about Health Herbal Clinic in Johannesburg South Africa who sell herbal treatments for diseases including FIBROMYALGIA disease, I contacted the herbal clinic via their website and purchased the fibromyalgia herbal remedy. I received the herbal remedy through DHL couriers within 8 days and i immediately commenced usage as prescribed, i used the herbal remedy for about a month and 1 week, my condition has greatly improved, all my symptoms including Chronic muscle pain, Abdominal pain, nausea, I am fibromyalgia free! contact Health Herbal Clinic via their email healthherbalclinic AT gmail DOT com or visit www DOT healthherbalclinic DOT weebly DOT com PLS fibromyalgia is not a death sentence, there is a cure!

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Feb 7th, 2017

Bernadette
G.
from Baraboo, WI
writes:

I was givendors Lupron in 2007. I have had intestinal issues and chronic muscle and joint pain since. It is getting progressively worse. I also have excessive facial hair and hyperprolactinemia. It might help to obtain information to determine any relationship for treatment options.

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Feb 6th, 2017

Kara
F.
from Ashland, OH
writes:

I was on Lupron in 1999 and received 6 injections in 6 months. I have developed a severe vitamin d deficiency, fibromyalgia, osteoarthritis, AS, and thyroid goiter and nodules to name a few. It didn't not help my endometriosis or PCOS.

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Feb 4th, 2017

Someone
from Arlee, MT
signed.

Jan 31st, 2017

Someone
from Bend, OR
signed.

Jan 31st, 2017

Someone
from Portland, OR
writes:

Given series of six (6) lupron injections for fibroids & endmometriosis in 2007 at age of 44. Since that time, I have developed degenerative disk disease, osteoarthritis, osteoporosis, Vit-D deficiency, cardiac issues AND now, rheumatoid arthritis.
Lousy drug. Too bad most of the Congress Critters are paid off by drug companies to enable bad drugs like this to be pushed to market.

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Jan 31st, 2017

Someone
from Portland, OR
writes:

Given series of six (6) lupron injections for fibroids & endmometriosis in 2007 at age of 44. Since that time, I have developed degenerative disk disease, osteoarthritis, osteoporosis, Vit-D deficiency, cardiac issues AND now, rheumatoid arthritis.
Lousy drug. Too bad most of the Congress Critters are paid off by drug companies to enable bad drugs like this to be pushed to market.

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Jan 28th, 2017

Alexis
S.
from White Plains, MD
writes:

I was given 2 rounds of Lupron in January 2014 (1st shot) and April 2014 (2nd shot) for severe endometriosis. I just turned 25 when Lupron treatment began and was diagnosed with endometriosis at 23. The shots gave me severe hot flashes, fatigue, chest pain, bone pain, irritability, worsened insomnia, and memory loss where I struggle to identify and pronounce words correctly. I had no issues with speech/memory before Lupron. After 6 months of treatment, I was told by my doctor that my symptoms would disappear and I would not likely experience them again. It is January 2017 and I still have memory problems, chest pain, joint pain, occasional hot flashes, and bone pain in my hips. I'm 27 but feel a lot older. I am unable to exercise due to recurring pelvic and hip pain. My endometriosis is not better and I have experienced increased gastro problems (internal hemorrhoids related to chronic constipation due to endometriosis) since discontinuing the drug. The "best" treatment for endometriosis, according to my GYN, is Lupron, but the side effects are horrendous! It is not worth it to be relieved of severe pelvic pain for 6 months just to have lasting side effects with no possible cure. Please do more investigations!

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Jan 27th, 2017

Sandra
C.
from Oak Forest, IL
writes:

Far too many FDA approved are causing more and worse problems than the original issue they were supposed to correct, especially where reproductive health is concerned. This drug needs to be stopped until THOUROGH research has been conducted as to it's long-term side effects.

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Jan 23rd, 2017

Kristen
S.
from Chicago, IL
signed.

Jan 17th, 2017

Someone
from Nordman, ID
writes:

I was given only one injection this past October, I began experiencing hot flashes almost immediately followed by horrendous migraines, insomnia & I can't help but wonder if recent muscle weakness (past couple of months) is also a result of Lupron. I was given the shot to help shrink a large fibroid, the doctors were estimating I would need 3 of the 3 month shots. Within 2 weeks of the shot I found myself in the ER with extreme abdominal pain due to an ovary distortion..... also a side effect of the Lupron. My surgeon performed an emergency hysterectomy & removed the 10 pound fibroid however the Lupron has of course remained in my system with all of the side effects it brings to the party. I've literally been counting the days (I only have 2 left!) until this potion is out of my system & I'm wondering how long it will take the side effects to go away....

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Jan 13th, 2017

Devon
K.
from Council Bluffs, IA
writes:

A report submitted by TAP (Takeda-Abbott Pharmaceuticals) in 1998 wrote that the manufacturers of Lupron(R) were concerned with bone-density loss in women who had taken the drug as a form of treatment. Despite their "concern", they did not conduct follow-ups with those women to track their long-term symptoms, and the FDA did not require them to. This is just one of many issues regarding the drug Lupron(R) and it's harmful side effects. The manufacturers and doctors who administer this drug claim that patients should only experience adverse side effects up to six months after use, but the Endometriosis Research Center completed surveys that show that 51.67% of respondents experience side effects that lasted LONGER than 6 months, and 23% had symptoms that lasted longer than 5 years.

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Jan 9th, 2017

Samantha
D.
from Greenville, KY
writes:

I had injections when i was 15/16 yrs old after being diagnosed with endometriosis at age of 13/14. Went thru many laparoscopic surgeries anddid injections. That helped barely a year maybe 2 tjen more laparoscopic surgeries, finally at 18 i got pregnant eben though i wasnt suppose to be able to and seemed to help about year after javing son then pain was back and another laparoscopic surgery and self medication on and off i fought with it. And at 22 i had a little girl with 2nd.pregnancy. and more laparoscopic surgery by 25 iwas done hurting and lived in Ky. And the obgyn offered a hysterectomy as permanent solution. But ive jad thru and after that terrible intestinal,stomache,bowel,arthritis,fibromyalgia,depression,severe anxiety, and still low back pain and bladder or cramps.

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Jan 6th, 2017

Terri
H.
from Powersite, MO
writes:

My Nitemare since Lupron has devasted my life physically and mentally for nearly 17 yrs now I have worked and suffered thru disabling pain Knowing I had a serious problem but did not know til I was in a auto accident so severe I had to be cut out of my car MRIs X-rays CTs showed sinificant existing destruction in my neck and back I have spinal stanosis Osteoporosis fabromialgia severe emotional challenges mvr colon disease broken teeth MAJOR FATIGUE to name a few. Over a dozen Drs surgeries and financial devastation and not 1 dr ever asked me if I had been injected with this chemo drug to treat severe endometriosis I have insured shame and pain far to long with No HELP OR resources Ssd has denied me for 5 yrs 2 Attornies many Drs and ssd totally ignorant of this crisis This is more than wrong Its Cruel!!!!!

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Jan 4th, 2017

Angela
H.
from Kingsland, GA
writes:

I took Lupron treatments 4 times. Once following surgery for 6mos. Another time no surgery 1yr. Then 2x. no surgery 6mos. I have and was diagnosed osteopenia at age 33. That was post Lupron treatments. I too was diagnosed tachycardia at age 36. I continues having symptoms, lost my teeth at 40yrs, and still have pelvic pain to this day. I now 42yrs of age have fibromyalgia on top of pelvic pain.
I feel this treatment should be monitored more with endometriosis and other female patients. I have endometriosis and ovarian cysts to this day. I felt like I was treated due to both like a test patient. Too many surgeries in combo with Lupron was just too much. They still RUN to Lupron treatment too quickly. At least is the case for me. I even had one physician state to only take Lupron once in your lifetime. I feel more tests of longterm effects need to be considered. The doctors went too fast for Lupron to be a cure all while not knowing STILL a lot about endometriosis or ovarian cysts, among other female issues.

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Jan 2nd, 2017

Sandra
H.
from Spotsylvania, VA
writes:

I too have neck problems in C6 &7 I have in layman's terms a slipped disc and lower back narrowing of the spine. Speratic weight gain, hair thinning, cystic acne and low Vit. D. I thought thyroid but my tests are normal. I am glad I found this. I am going to bring it to my doctor. I am scared now. Been 5 years ago for the injections only got 2 in 6 months back then.

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Jan 2nd, 2017

Someone
from Spotsylvania, VA
writes:

This needs to be done. I had the injections 5 years ago to treat endometriosis. It was 2 shots in 6 months. I gained close to 40 pounds. One pro my hair became curly the way I always wanted. It did help my endometriosis but, that could also be to the doctor lazering the cells away. 5 years later I keep gaining wright, tired all the time. Had thyroid checked it is not that. My hair is thin and brittle. I also have spine and neck problems. All my issues started after these dhots in 2011. Today I was googling long term side effects from Lupron. Of course no information. I do not know if my problems are from tjis but, I really want to know what is happening to me. I also have cyst acne. I am falling apart. I just turned 39 but been fighting for 5 years.

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Jan 2nd, 2017

Someone
from Houston, TX
writes:

I am 32 years old. I took injections for a combined 4 years to treat endo. My treatment ended at the age of 26 and I had a partial-hysterectomy at 28. Four years ago my neck broke in 2 places without cause or incident resulting in immediate surgery and fusion of C6-C7, ongoing testing showed that I had osteopenia. I suffered from unknown auto immune disease and controlled the symptoms with a gluten free diet until a year ago. I suffered a massive eschemic stroke on August 6, 2015. I was expected to not survive but my doctor performed a new procedure to remove the clot despite my advanced stages and I had an incredible recovery. Now I continue to fight unknown auto immune issues and blood deficiencies. I was a young woman with no knowledge of the long term affects of this medication simply trusting my doctor whom was the former head of Texas Woman's Hospital. I believed he would lead me in the right direction. Now I fear for my life. I am a mother of 3 young children. He told me the goal of the injections was to make me a mother. What is the point of becoming a mother, if I'm not alive to raise my children?

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Dec 26th, 2016

Stacy
D.
from Elkton, MD
writes:

I have undert-treated chronic joint pain that limits my activity level so severely that I am less physically active than my 68-year-old mother. I am 45. I've had lupron-depot therapy twice in my life. One episode was in my late twenties for 6 months. The other was in my mind-thirties for 4 months. I could not go the full 6 months because I was experiencing extreme feelings of rage and yelling at my small children. I underwent these treatments for severe endometriosis. I have since had a hysterectomy at age 42. I don't remember what it was like to live without pain. You can see by my social security statement how severely this has affected my income over the years. I am trying once again to work a full-time job. I am hoping that now that my kids are older they can share the household duties with me so that I can save my energy for work.

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Dec 21st, 2016

Allyson
S.
from Stafford, VA
writes:

I have suffered irreversible joint damage and tooth loss since taking the injections. This will be a life long battle. I still needed surgery which resulted in an infection and two more surgeries. Everyday it seems to be something.

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Dec 21st, 2016

Someone
from Sierra Vista, AZ
writes:

Had ovarian cysts. I wanted them surgically removed but doctor said we should try birth control first. Birth control makes me horrifically depressed, so I told her I couldn't do that. So, she told me that Lupron would stop the estrogen, make me a little dry, and maybe moody for a bit while the cysts shrank due to lack of estrogen. WHY did I agree? I had the 3 month shot. I now have a pain syndrome called Fibromyalgia and neuropathy. I also have pelvic nerve damage and damage to my bladder that is so severe that I've been begging doctors to remove my bladder. My muscle pain and neuropathy in legs/feet and hands/arms is so bad that I'm now bedridden. It has been 3 years since Lupron. I used to be a teacher; now I cannot take care of my 6 year old. My big goal each day is to get out of bed and try to walk my daughter to the bus stop. I've been on so many meds since and nothing works to lower the pain; and most meds have serious side effects that I cannot tolerate. I'm on Celebrex, Gabapentin, and Buspar and it is like they are placebos. Also, I never used to have a problem with heights or light or loud sounds --- now I cannot even think of a high place without keeling over. My family cannot touch me. Anything I attempt to use my muscles for, like keeping up my back, is a futile venture. Oh, and did I mention the 2 neurofibroma tumors, the extreme bone spur growth in my mouth, and the kidney stones that formed within 3 months of taking Lupron. My life has been destroyed and the worst part is that no doctor will admit that Lupron did this to me. I'm in hell.

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Dec 8th, 2016

Someone
from Demarest, NJ
writes:

My father was administered Lupron to treat prostate cancer and he now has developed debilitating arthritis and osteoporosis. This drug needs to be investigated for severe side effects especially for patients over 70.

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Dec 8th, 2016

Someone
from Waterford, ME
writes:

I am suffering from over a week of memory loss, loss muscle tone, achy joints and food aversions. I had a great life before I received 5 injections. Now I'm disabled and can no longer work! I loved my life before and wish I never took this drug! This drug is poison!