Biological tissues usually contain distinct water compartments with different transverse relaxation times. In this study, two-dimensional, multi-slice, ultrashort echo time spectroscopic imaging (UTESI) was used with bi-component analysis to detect bound and free water components in musculoskeletal tissues. Feasibility studies were performed using numerical simulation. Imaging was performed on bovine cortical bone, human cadaveric menisci and the Achilles' tendons of volunteers. The simulation… CONTINUE READING

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Figure 2. Ultrashort echo time spectroscopic imaging (UTESI) of a bovine femur segment (A–F) and bi‐component fitting of the UTESI images (G). The fitting showed a short T2* of 0.35 ± 0.01ms and a long T2* of 2.25± 0.02ms with fractions of 75.7% and 24.3%, respectively.