San Antonio raced out to a 17-point lead in the first quarter, then came up with a response when Memphis rallied to get within six in the second half. Both teams pulled their starters with over five minutes left and the Spurs leading by 21.

“I can promise you this: Nobody’s happy in our locker room, because we were up 2-0 (in the West finals) last year and we lost,” Parker said. “It’s just one game. It means nothing. We still have a long way to go.”

The Spurs avoided a repeat of their Game 1 loss when the teams met two years ago in the first round. The Grizzlies went on to knock San Antonio out of the playoffs as the top seed that time.

Memphis has lost its opener in each round of this year’s playoffs, recovering from an 0-2 hole in the first round against the Los Angeles Clippers and an 0-1 deficit against Oklahoma City in the West semifinals.

Game 2 is Tuesday night in San Antonio.

“We just didn’t play well. It’s not anything specific,” Grizzlies coach Lionel Hollins said. “It’s just that we were running too fast. We missed some layups. We were taking bad shots and our defense was really awful. And the Spurs played well.”

The NBA’s stingiest defense wasn’t up to its usual standards, allowing the Spurs to hit 53 percent of their shots and a franchise-postseason-record 14 three-pointers while All-Star power forward Zach Randolph struggled. Randolph had just two points, getting his only basket with 9:26 left in the game.

He had a playoff-best 28 points and 14 rebounds in his last game, as Memphis eliminated defending West champ Oklahoma City in Game 5 on Wednesday.

“Obviously, he’s their best scorer. He’s a beast inside,” Parker said. “We know he’s not going to play like that every game. It’s just sometimes it happens.”

Former Huskies star Quincy Pondexter led Memphis with 17 points, including five 3-pointers. Marc Gasol scored 15 and Mike Conley had 14 points and eight assists.

The Grizzlies’ second-half rally started when Pondexter made a baseline cut for a layup off Darrell Arthur’s pass, then hit back-to-back three-pointers during a 10-0 burst. Memphis cut its deficit to 62-56 before Manu Ginobili sparked an 11-1 response that immediately restored the Spurs’ lead to 16.