Layzie Bone, Krayzie Bone, Wish Bone, Bizzy Bone and Flesh-N-Bone have not shared a stage together in their hometown of Cleveland in years. They were set to perform at the Ohio Homecoming concert here last summer, but the outdoor show was called off because of stormy weather.

The rap group won a Grammy Award for its chart-topping 1996 breakthrough single “Tha Crossroads.”

Lately, however, Bone Thugs-N-Harmony’s career has hit a few sour notes.

During a 2010 concert at Cleveland’s House of Blues (where Bizzy was MIA), Flesh-N-Bone was arrested on an assault charge stemming from a 1998 incident in Solon, where he allegedly struck his mother with a gun. After his mother denied the attack, prosecutors dropped the charge. Flesh-N-Bone pleaded guilty to disorderly conduct and was ordered to pay a $250 fine.

Last year, Krayzie announced that he was leaving the group.

Nonetheless, all members will be back onboard for the Agora show, Layzie said.

They’re also on the Rock the Bells Tour, with stops in California and New Jersey in August and September.

“I anticipate smooth sailing,” Layzie said.

“We’ve been friends for the majority of our lives. We have different ambitions sometimes. But Bone Thugs-N-Harmony is the most significant thing we’ve built.”

The Agora looms large in their history. In the early 1990s, they auditioned backstage there for N.W.A.’s Eazy-E, who offered them a record deal soon afterwards.

The Bone Thugs-N-Harmony show is one of several engagements that Agora operator Hank LoConti has lined up in advance of a planned 2013 centennial celebration of the venue, originally known as the Metropolitan Theater when it opened in 1913. It went through various other incarnations until 1985, when the Agora moved in following a previous run on East 24th Street.

“This is a landmark building,” LoConti said. “It has a long history of entertainment.”

Todd Rundgren is booked Friday and Saturday, Oct. 12-13, at the Agora, and Mushroomhead is set to play there Saturday, Oct. 27.

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