This database is dedicated to categorize CREB target genes in a comprehensive and easy-to-search way. CREB database has used a multi-layered approach to predict, validate and characterize CREB target genes.

For each gene, the database tries to provide the following information:
1. CREB binding sites on the promoters
2. Promoter occupancy by CREB
3. Gene activation by cAMP in tissues
CREB seems to occupy a large number of promoters in the genome (up to ~5000 in human), and the profiles for CREB promoter occupancy are very similar in different human tissues. However, only a small proportion of CREB occupied genes is induced by cAMP in any cell type, possibly reflecting the requirement of additional regulatory partners that assist in recruitment of the transcriptional apparatus.
To use the database, choose the species, select the table your want to search, leave field as it as ('All') and type in the gene you want to search. A table listing the search results will be returned, followed by the description of the table. If no search result is returned, try use the official gene symbol or gene ID (locuslink number) from NCBI Entrez Gene.

Sponsors: This work was supported by National Institutes of Health Grants GM RO1-037828 (to M.M.) and DK068655 (to R.A.Y.).

Contributors

*Note: Neurolex imports many terms and their ids from existing community ontologies, e.g., the Gene Ontology. Neurolex, however, is a dynamic site and any content beyond the identifier should not be presumed to reflect the content or views of the source ontology. Users should consult with the authoritative source for each ontology for current information.

For each gene, the database tries to provide the following information:
1. CREB binding sites on the promoters
2. Promoter occupancy by CREB
3. Gene activation by cAMP in tissues
CREB seems to occupy a large number of promoters in the genome (up to ~5000 in human), and the profiles for CREB promoter occupancy are very similar in different human tissues. However, only a small proportion of CREB occupied genes are induced by cAMP in any cell type, possibly reflecting the requirement of additional regulatory partners that assist in recruitment of the transcriptional apparatus.
To use the database, choose the species, select the table you want to search, leave field ('All') and type in the gene you want to search. A table listing the search results will be returned, followed by the description of the table. If no search result is returned, try the official gene symbol or gene ID (locuslink number) from NCBI Entrez Gene to search.

Sponsors: This work was supported by National Institutes of Health Grants GM RO1-037828 (to M.M.) and DK068655 (to R.A.Y.). (to M.M.) and DK068655 (to R.A.Y.).