A man and his 2-year-old son were killed when their vehicle collided with a tractor-trailer on Route 222 in Manheim Township Monday night. The man’s wife and their 4-year-old daughter remain hospitalized.

Manheim Township Police will continue to investigate the circumstances behind crash, which occurred at the Landis Valley Road overpass at 6:50 p.m.

Joshua Allen West, 40, of Denver, was reportedly pronounced dead at the scene by a deputy coroner. Katie M. West, 37, and both children were transported to a hospital for treatment. The 2-year-old later died, according to a police report.

As of Wednesday morning, Katie was listed in serious condition at Lancaster General Hospital. The daughter’s condition was not available.

Police said the family’s vehicle collided with a tractor-trailer and flipped onto its roof in the northbound lanes of Route 222. The driver of the truck, Mawuyrayrassuna E. Noviho, 21, of Newport News, Va., was taken to a hospital and treated for minor injuries, police said.

Northbound Route 222 was reportedly closed from the Route 30 interchange to the Oregon Pike exit, resulting in traffic backups on Oregon and New Holland pikes.

No further information was available as of Wednesday morning. Anyone who may have witnessed the crash or has information is asked to contact the Manheim Township Police Department at 569-6401.