Eastern's main campus is located in Wilburton, Oklahoma, which is in the heart of the valley between the San Bois and Winding Stair Mountain Ranges.

The campus features multiple classroom buildings and four residential housing options, including brand new apartment-style housing completed in 2012. In addition to these buildings, the campus also houses a recently built student center, which features multiple several dining options, a ballroom and common area. The recently renovated student enrollment center in the library building is a one-stop destination for new and current students. Other renovations include the newly completed Johnnie Wray Theatre in Pratt Hall, complete renovations of Gunning and Baker Halls and a new athletic training facility dedicated to Coach Stone, which will break ground in 2013.