To the Editor: In their study of very high-intensity statin therapy, Dr Nissen and colleagues1 found that use of a high-dose statin may be able to reverse atherosclerosis. However, I am concerned about statements in the article such as “regression was achieved by reducing LDL-C” that imply that it was changes in low-density lipoprotein cholesterol (LDL-C) or high-density lipoprotein cholesterol (HDL-C) that were responsible for the observed plaque regressions.