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I have AS. It can be difficult to diagnose for some people. HLA-B27 is a genetic test. It doesn't change over time and you cannot become positive. Several genetic markers have been associated with AS. HLA-B27 is by far the most informative. Since most people with AS have HLA-B27. Yet, being positive for that gene alone does not indicate anyone has AS. 7.5% of white people in the USA have HLA-B27, yet less than 5% of those people ever get AS. Some people definitely have AS but do not have the gene. Only a Rheumatologist should make an AS diagnosis. 10-15% of people with AS have symptomatic IBD such as Crohn's or Ulcertive Colitis. see www.spondylitis.org for more information. Best wishes,

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Celiac.com was founded in 1995 by Scott Adams, author of Cereal Killers, founder and publisher of Journal of Gluten Sensitivity, and founder of The Gluten-Free Mall, who had a single goal for the site: To help as many people as possible with celiac disease get diagnosed and living a happy, healthy gluten-free life!