1. DOCID:27123 SCORE: 0.0020029033437485DOCNO: 11551135OWNER: NLMSTATUS: MEDLINEDESCRIPTOR: LaparoscopyQUALIFIER: surgeryAUTHOR: D F Dargent DFAFFILIATION: Department of Gynecologic Oncology, Hospital Edouard Herriot, Lyon, France.PUBTYPE: Journal ArticlePUBTYPE: ReviewJOURNALTITLE: The Surgical clinics of North America. COUNTRY: United StatesTITLE: Laparoscopic surgery in gynecologic oncology.PUBDATE: 20010801
Laparoscopy found its first application in the field of gynecology. Today, laparoscopy benefits the general gynecologist because of its minimally invasive nature. Benign procedures, such as oophorectomies and hysterectomies, have become practically outpatient procedures. The learning curve for laparoscopy in gynecologic cancer operations is obviously steeper, more time consuming, and training-dependent. With increased operative time, cost, and the questions of safety in malignant conditions, laparoscopy has quite a burden of proof before it becomes widely accepted. This article reviews the current applications of laparoscopy in gynecologic oncology with available data and offers future directions best suited for laparoscopy in this subspecialty.

4. DOCID:27913 SCORE: 0.00188062358781652DOCNO: 11014091OWNER: NLMSTATUS: MEDLINEQUALIFIER: surgeryAUTHOR: M Matter MAUTHOR: M Dusmet MAUTHOR: F Chevalley FAFFILIATION: Service de chirurgie, Centre Hospitalier Universitaire Vaudois, Lausanne. Maurice.Matter@chuv.hospvd.chPUBTYPE: Journal ArticleJOURNALTITLE: Revue médicale de la Suisse romande. COUNTRY: SWITZERLANDTITLE: [The place of surgery in the treatment of advanced localized, recurrent and metastatic breast cancer]PUBDATE: 20000601
In the multidisciplinary treatment of locally advanced and metastatic breast cancer, aggressive surgical options can be chosen in selected cases. They may allow: survival to be prolonged by the resection of metastases (liver, ovary, lung), symptomatic treatment (bone pain, local recurrence, infiltration of the chest wall), prevention of potentially disabling complications (pathologic fractures, medullary compression), exclusion of another tumoural or non tumoural diseases. The decision to perform surgery has to be discussed between the surgeon and the oncologist so as to optimise its timing. Surgical treatment can follow induction therapy or can precede chemo- or hormonotherapy.

5. DOCID:27664 SCORE: 0.00184492598489288DOCNO: 11218389OWNER: NLMSTATUS: MEDLINEQUALIFIER: geneticsAUTHOR: T Nakazawa TAFFILIATION: Yamaguchi University School of Medicine.PUBTYPE: Journal ArticlePUBTYPE: ReviewJOURNALTITLE: Nippon rinsho. Japanese journal of clinical medicine. COUNTRY: JapanTITLE: [Progress of molecular bacteriological studies on Helicobacter pylori]PUBDATE: 20010201
To understand pathogenesis of H. pylori in stomach diseases including gastric cancer, molecular bacteriological studies are important. The studies are greatly advanced by information of the whole genome sequence of this bacterium in 1997. Various methods of gene manipulation to identify the genes involved in pathogenesis are now available such as transformation followed by construction of knockout mutants, complementation using H. pylori-E. coli shuttle vectors, random insertion mutagenesis, and RT-PCR or proteome analysis of in vivo-expressed genes. The molecular mechanism of persistent infection of H. pylori is discussed in light of recent findings on molecular mechanisms of bacterial attachment and colonization as well as on gastric physiology.

6. DOCID:31693 SCORE: 0.00177229367105133DOCNO: 12470982OWNER: NLMSTATUS: MEDLINEDESCRIPTOR: ClimactericDESCRIPTOR: NeoplasmsQUALIFIER: drug therapyAUTHOR: Mark Clemons MAUTHOR: Andrew Clamp AAUTHOR: Beverley Anderson BAFFILIATION: Division of Medical Oncology, Toronto-Sunnybrook Regional Cancer Centre, Ont., Canada. mark.clemons@tsrcc.on.caPUBTYPE: Journal ArticlePUBTYPE: ReviewJOURNALTITLE: Cancer treatment reviews. COUNTRY: EnglandTITLE: Management of the menopause in cancer survivors.PUBDATE: 20021201
The consequences of premature menopause are of great importance to cancer survivors. Oestrogen replacement therapy (with and without added progestins) is the most extensively researched agent for the treatment and prevention of menopausal problems. While this may be appropriate for symptom control in patients with tumours that are not hormone responsive, patients with hormone dependent tumours will require safe and effective alternative treatments for menopausal symptoms. This paper will discuss both the short-term and long-term consequences of the menopause in cancer survivors and will also offer various management strategies.

7. DOCID:31574 SCORE: 0.00177168047648427DOCNO: 12324259OWNER: NLMSTATUS: MEDLINEQUALIFIER: physiologyQUALIFIER: methodsQUALIFIER: trendsAUTHOR: Sanjay Tickoo SAUTHOR: Steven Russell SAFFILIATION: Department of Genetics, University of Cambridge, UK. s.tickoo@gen.cam.ac.ukPUBTYPE: Journal ArticlePUBTYPE: ReviewJOURNALTITLE: Current opinion in pharmacology. COUNTRY: EnglandTITLE: Drosophila melanogaster as a model system for drug discovery and pathway screening.PUBDATE: 20021001
Although the freakish nightmare world of Mr Samsa may seem completely divorced from our view of the real world, the comparisons between the Drosophila and human genomes indicate that we are a lot closer to insects than we like to think. The use of sophisticated genetic approaches combined with emerging genomics technologies suggest that the fly has much to offer as a tool for understanding basic cellular processes and provides an attractive and complex model system for exploring the molecular basis of human diseases such as cancer, Alzheimer's disease and Huntington's disease.

8. DOCID:30872 SCORE: 0.00176617674793824DOCNO: 12087588OWNER: NLMSTATUS: MEDLINEQUALIFIER: adverse effectsQUALIFIER: therapeutic useQUALIFIER: drug therapyQUALIFIER: drug effectsAUTHOR: Les Lockridge LAUTHOR: Rose J Papac RJAUTHOR: Mark A Perazella MAAFFILIATION: Department of Medicine, Section of Oncology and Section of Nephrology, Yale University, New Haven, CT 06529-8029, USA.PUBTYPE: Case ReportsPUBTYPE: Journal ArticleJOURNALTITLE: American journal of kidney diseases : the official journal of the National Kidney Foundation. COUNTRY: United StatesTITLE: Pamidronate-associated nephrotoxicity in a patient with Langerhans's histiocytosis.PUBDATE: 20020701
Pamidronate is used frequently to treat malignancy-associated hypercalcemia and osteolytic lesions. This widely used bisphosphonate has been noted to cause nephrotoxicity in patients with multiple myeloma and metastatic breast cancer. We encountered a patient with Langerhans's histiocytosis who developed nephrotic syndrome and renal failure after pamidronate therapy. We describe the clinical and renal biopsy findings in this patient.

9. DOCID:27905 SCORE: 0.00176512137442102DOCNO: 11192793OWNER: NLMSTATUS: MEDLINEQUALIFIER: pathologyQUALIFIER: pathologyQUALIFIER: pathologyAUTHOR: M Hut'an MAUTHOR: M Salapa MAUTHOR: J Bandzák JAUTHOR: P Baláz PAFFILIATION: Chirurgické oddelenie NsP Ruzinov, Bratislava, Slovenská republika.PUBTYPE: Journal ArticleJOURNALTITLE: Rozhledy v chirurgii : měsíčník Československé chirurgické společnosti. COUNTRY: Czech RepublicTITLE: [The current method of staging gastrointestinal (GIT) tumors]PUBDATE: 20001001
The authors analyzed in a retrospective study the stage of carcinomas of the stomach and colorectum in their material. In 1996-1998 they operated 35 patients with gastric tumours and 77 patients with colorectal cancer. In both groups they operated more than 50% of the patients in the IIIrd or more advanced stage of the disease. 22.8% gastric tumours and 19.5% colorectal tumours were operated in the acute stage. The situation in the group is alarming, it is essential to improve the early diagnosis and thus also treatment in all links of the chain: patient--attending physician--surgeon--society.

11. DOCID:27765 SCORE: 0.00174235400645359DOCNO: 12066020OWNER: NLMSTATUS: MEDLINEQUALIFIER: diagnosisQUALIFIER: nursingQUALIFIER: complicationsQUALIFIER: methodsAUTHOR: S Brown SAUTHOR: L F Degner LFAFFILIATION: Faculty of Nursing, University of Manitoba, Winnipeg, Canada.PUBTYPE: Journal ArticlePUBTYPE: ReviewJOURNALTITLE: International journal of palliative nursing. COUNTRY: EnglandTITLE: Delirium in the terminally-ill cancer patient: aetiology, symptoms and management.PUBDATE: 20010601
Delirium is a frequent and serious clinical problem in the terminally ill cancer patient. Multiple dimensions of delirium make definition, measurement, and assessment of it challenging in clinical nursing practice. Assessment and management of delirium requires knowledge of the diagnostic criteria for it, aetiology, signs and symptoms, and nursing interventions. Four delirium assessment scales determined to be useful in assessing patients with terminal illness are reviewed. The use of a delirium assessment instrument in routine nursing assessments would be important for the nurse's early detection of delirium so that interventions to reverse the causes of delirium could immediately be implemented.

12. DOCID:26607 SCORE: 0.00173622557584259DOCNO: 9989206OWNER: NLMSTATUS: MEDLINEQUALIFIER: geneticsAUTHOR: S Narod SAFFILIATION: Department of Medicine, Women's College Hospital, Toronto, Ont., Canada. narod@ftn.netPUBTYPE: Journal ArticlePUBTYPE: ReviewJOURNALTITLE: Biochimica et biophysica acta. COUNTRY: NETHERLANDSTITLE: Genetic epidemiology of prostate cancer.PUBDATE: 19990101
A family history of prostate cancer is a consistent risk factor for prostate cancer, and can also be used to predict the presence of prostate cancer among asymptomatic men who undergo PSA screening. Approximately 5% of cases of prostate cancer have a familial component. The genetic epidemiology of prostate cancer is complex, and genes on chromosome 1 and X chromosome contribute to familial aggregation. Neither of these prostate cancer susceptibility genes have been identified, but are the subject of an active search. Hereditary prostate cancer resembles non-hereditary cancer in terms of age of onset, pathologic appearance and grade.

14. DOCID:26365 SCORE: 0.00172745604538964DOCNO: 11797393OWNER: NLMSTATUS: MEDLINEQUALIFIER: diagnosisQUALIFIER: geneticsAUTHOR: R Kushima RAFFILIATION: Department of Clinical Laboratory Medicine, (Central Clinical Laboratory), Shiga University of Medical Science, Ohtsu 520-2192.PUBTYPE: Journal ArticlePUBTYPE: ReviewJOURNALTITLE: Rinsho byori. The Japanese journal of clinical pathology. COUNTRY: JapanTITLE: [Relationship and role of morphological diagnosis and gene diagnosis of cancer (1) tumors in the gastrointestinal tract]PUBDATE: 20011201
At present histopathological examination based on clinical findings is the most important and definitive method of diagnosing gastrointestinal tumors. In this field, gene analysis is sometimes used as a supplemental diagnosis. However, fruitful analyses of gene abnormalities in gastrointestinal tumors have facilitated thoughtful morphological diagnosis. Gene diagnosis is expected to play an important role in the grading of malignancy, examining sensitivity for chemotherapy and discovering micrometastases, in cases of cancers definitively diagnosed by histopathology.