The data presented here support the conclusion that rare genetic variants in MAT2A predispose individuals to thoracic aortic disease.

Results suggest that MAT2A is downregulated in cancer tissues of renal cell carcinomas patients and has function of tumor suppressor though repressing the expression of heme oxygenase-1 (show HMOX1 ELISA Kits).

Differential gene expression of BACE1 (show BACE ELISA Kits) and PSEN1 (show PSEN1 ELISA Kits) in the knockdown cells, which is possibly a consequence of MAT2A deregulation and may indicate a self regulatory mechanism.