Spiraling toward success

Adina Mangubat (UW BS in psychology, 2009), CEO of Spiral Genetics, has “change the world” in her DNA, and the world is taking notice. In the past two years, Mangubat has been interviewed by news outlets like Xconomy and GeekWire, and featured on Forbes’ list of the top 30 under 30 in science and technology. Why all the attention? Spiral Genetics is using sophisticated algorithms, distributed computing, and a cloud-based framework to change the way DNA is analyzed.

In the most basic terms, there are two parts to processing DNA. First, DNA is extracted from blood or tissue and put into a sequencer that chops up and reads the DNA, resulting in millions of raw reads, “essentially text files of As, Cs, Gs, and Ts,” explains Mangubat. Next, these millions of text files are organized, analyzed, and compared to a normal DNA sequence to find unexpected variants. Researchers use these variants to identify gene mutations that are the cause of everything from color blindness to cancer.

Mangubat and her cofounders, CSO Becky Drees (UC Berkeley PhD in Molecular & Cellular Biology, 1995 and UW Certificate in Biotechnology Project Management, 2008) and CTO Jeremy Bruestle, have developed a platform that significantly speeds up the analysis process. Spiral Genetics can analyze in hours what has previously taken biologists days to complete using complicated open source software. “As far as I know,” Mangubat says, “we’re the fastest in the world. We can process raw reads down to a list of annotated DNA variants in three hours for a human genome.” This is especially significant as DNA sequencing gets faster and faster, and biologists are unable to keep up with the resulting mountains of analysis-ready data. Spiral Genetics is also highly accurate and scalable, able to detect genetic variations that most analyses might miss. “We’ve far ahead of the curve in our ability to handle datasets,” states Mangubat.

Another thing that sets Spiral Genetics apart is that its software is designed to analyze DNA for multiple species. As Xconomy recently pointed out, while similar companies are focused specifically on the human genome, SpiralGenetics also analyzes genomes for animals and plants, which could have implications in agricultural research and development.

Mangubat didn’t set out to become a leader in DNA analysis. Just four years ago, she was a senior who simply knew that she liked being an entrepreneur (she had been involved in two startups by that time), so she registered for Professor Alan Leong’s Technology Entrepreneurship class. There she met Drees, who was interested in starting a genetic analysis company.

Drees and Mangubat joined forces and pitched Spiral Genetics as a consumer-genetics service in the 2009 Business Plan Competition, but soon realized they were late to that party and needed a new model. Mangubat took the pivot in stride. In a moment of inspiration, the team (including Bruestle) decided to bet on the fact that the research community would soon need software that could keep up with the increased speed of DNA sequencing, and Spiral Genetics was reborn.

Three years later, their bet is paying off. In early March, Spiral Genetics announced $3 million in financing from venture firm DFJ, have begun to scale significantly. “We’re in the process of essentially doubling the size of our team,” says Mangubat. The company currently has eight employees, but plans to double in size in the near future, adding more developers and a sales team, as demand increases. “The explosive growth of the market is driving our business,” she explains. “We’re about to get much bigger very quickly, which is exciting.”

As for changing the world, Mangubat is confident. “Long term,” she says, “my goal is to make the process of figuring out what raw sequence data means as easy and as fast as possible, and we are seriously getting there.” In the meantime, Spiral Genetics is already making its mark. “We’re working with groups that are doing pediatric cancer diagnosis – you can’t get much more meaningful than that.”