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Microglia are a type of cell located in the brain and spinal cord, and act as an active immune defense in the central nervous system. As researchers from the University of California wrote: “Microglia play critical roles in brain development, homeostasis, and neurological disorders”.

These scientists attempted to study their function in relationship to neurological diseases, such as Alzheimer’s, to provide important new insight into human neurological disease. Specifically, they report that microglial-like cells, iPSC-dervied microglia (iMGL), can be differentiated from induced pluripotent stem cells (iPSC).

During their studies, they used Novoprotein Recombinant Human CD200 to culture iMGLs in complete differentiation media. This was the final step in allowing differentiation of iHPCs to iMGLs, done after 25 days of microglial differentiation (35 days from iPSC)

From their studies, they were able to conclude links between genes expressed from iMGLs to Alzheimer’s Disease (AD), Amyotrophic Lateral Sclerosis (ALS), Huntington’s Disease (HD), Frontal Temporal Dementia (FTD), and Dementia with Lewy Bodies (DLB).

Perhaps information from this study will become invaluable for future studies into these neurological diseases. Novoprotein looks forward to the opportunity to assist again, and is proud of the scientific community and all its achievements; both current and future.

Recently, we provided our CK02 and CK15 products to researchers from the University of Georgia (USA) and the Huazhong Agricultural University (CHINA) who, in turn, researched a vaccine expressing CXCL13 that enhanced humoral immunity by Recruiting both T Follicular Helper and Germinal Center B Cells.

Rabies has been documented since 2000 B.C., but vaccines have only been around since 1885. Since then, many methods and vaccines have been created to treat and prevent the Rabies virus. Yet, as they wrote:

“Rabies still remains a public health threat in most parts of the world, and approximately 99% of the cases are transmitted by dogs. There is an urgent need to develop an efficacious and affordable vaccine to control canine-transmitted rabies in developing countries.”

Take a look into their published findings in the Journal of Virology from the American Society for Microbiology here:

Rabies is endemic in most parts of the world, and more effort is needed to develop affordable and effective vaccines to control or eliminate this disease. The chemokine CXCL13 recruits both Tfh and B cells, which is essential for the homing of Tfh cells and the development of B cell follicles. In this study, the effect of the overexpression of CXCL13 on the immunogenicity of the RABV was evaluated in a mouse model. We found that CXCL13 expression promoted humoral immunity by recruiting Tfh and GC B cells, facilitating the formation of GCs and increasing the number of plasma cells. As expected, the overexpression of CXCL13 resulted in enhanced virus-neutralizing antibody (VNA) production and protection against a virulent RABV challenge. These findings provide a better understanding of the role of CXCL13 in RABV-induced immune responses, which will help in designing more efficacious rabies vaccines.

Bigger…

It’s 2016, and we’ve officially outgrown our office. As we grow in customer base and product catalogue, we need to grow in facility and faculty. Our little office turned from ‘warm and cozy’ to ‘tight and cramped’ rather quickly, so we decided to expand!

We now have a larger facility at a new address! Please take note, the new address is:

Our original address at 47 Maple St. is still accessible by us for mail, but we are asking all our colleagues to update to the new address for convenience and speed in processing postal paperwork or receiving packages.

…Better…

We are in the process of implementing a quality assurance initiative which will be initiated, in part, by our customers and colleagues! Feedback is important, but often goes unsaid. We’re working on a few ways to receive your evaluations, and we plan on being more proactive in receiving such input, as opposed to the current passive model.

Also, stay on the lookout for our End-of-Fall sale! We’ve got some big items at discounted prices. And remember, we have bulk pricing all year round. Simply ask for a quote from one of our sales representatives, tell us which product, and how many milligrams you would like, and we will be happy to give a generous discount, dependant on the quantity.

You can contact sales by email (sales@novoprotein.com) or by phone (1-973-671-8010), or can even request a quote from our website! You can do that here.

…and Bigger again!

Novoprotein now has over 1920 catalogue proteins. We’ve officially hit the ‘roaring twenties’ of catalogue size. Science is seemingly infinite in scope and size, and the amount of research is exponentially increasing every year. As such, we’re dedicated to growth to meet the demands of our colleagues in the scientific community. We are committed on continued provision of quality products and services for as long as there is a demand.

Expect our new “Catalogue 5.0” to be released by November, which will include all of our products, as well as information on how to get custom ‘off menu’ proteins made to your specifications. We look forward to continued growth, as we complete more and more

A Family of Diseases:

Each year 12.7 million people discover they have cancer and 7.6 million people die from the disease, but even despite the numbers and the commonality, cancer is still not very well understood by the public, and still remains a difficult topic for scientific and medical professionals.

A common misconception by the public is that ‘cancer’ is a single, monolithic entity; that every cancer is the same. With such thinking, one would expect there be a single, one-size-fits-all cure that can be obtained. However, life is never so simple. Cancers are, in fact, a large family of diseases. These diseases affect cell growth and can spread quickly throughout the body. Not only are cell growth & division advanced by cancers, but lowers or effectively eliminates apoptosis. Apoptosis, also known as “programmed cell death”, is a normal way for your body to get rid of older or excessive cells. Average humans loose tens of billions of cells a day, which allows for maintaining balance in the body. However, the combination of rapid cell growth, and lowered cell deletion results in characteristic tumors, yet can also lead to many other (often misleading) symptoms.

Scientists have long since been working on researching cancer, and while there are now vasts quantities of knowledge on the subject due to decades of research, there is an untold amount we still do not know. The fight against cancer continues, and the first steps are taken in laboratory settings.

Laboratory Front Lines:

So many advancements are happening in the medical field, it is easy to be overwhelmed by it all. Yet understanding the methods scientists use, and the steps involved, helps structure these advancements, and frame them in an understandable concept.

Another thing to remember before continuing, especially in a sensationalist society, is to take experiments (even those published) with a grain of salt. The scientific community has a system of checks and balances; although one person may find correlations in data, there is a process the experiments and theories must go through before they are accepted as fact. That being said, these initial experiments and theories are the first steps in solving the problems they face, and if they can be recreated by others and can be verified, they are invaluable beginnings to new advancements.

That being said, let us look at some of the most recent advancements in cancer research, and those of which involved Novoprotein’s products.

Publications:

Science China Life Sciences is a peer-reviewed open access cademic journal co-sponsored by the Chinese Academy of Sciences and the National Natural Science Foundation of China. With 168 issues to date (06/08/2016) since 1997, over two thousand articles have been published. In the April 2016 edition of Life Sciences, dealt with tumors and CAR-T therapy to show that “MUC1 positive metastatic seminal vesicle cancer can be effectively eradicated”.

Food & Function provides a unique venue for physicists, chemists, biochemists, nutritionists and other food scientists to publish work at the interface of the chemistry, physics and biology of food. The February 2016 edition of Food & Function dealt with anticancer activities that stem from Trichosanthes kirilowii fruit. This has an effect on apoptosis.

Biochemical and Biophysical Research Communications, shortened as BBRC, is an international journal devoted to the very rapid dissemination of timely and significant experimental results in diverse fields of biological research. In May 2016, BBRC published anticancer effects that targeted specific signaling.

Scientific Reports, which is under The Nature journals, has thousands of peer-editors, and is a central resource for information about open access and open research at Nature Publishing Group. The April 2016 publication of Scientific Reports involved a well-known tumor-suppressive miRNA that is frequently downregulated in multiple cancers.

Spandidos Publications was founded in 1992 and has developed into a leading publishing group in the biomedical sciences field. SP currently publishes eight journals: International Journal of Molecular Medicine, International Journal of Oncology, Molecular Medicine Reports, Oncology Reports, Experimental and Therapeutic Medicine, Oncology Letters, Biomedical Reports and Molecular and Clinical Oncology. The November 2015 Molecular Medicine Reports journal also dealt with downregulated expressions.

More and more is published every month, and there are plenty of older articles as well, but Novoprotein is proud to be a part of each and every discovery that we can. We delight in the chance to provide researchers with the tools needed to reach these advancements, and look forward to continuing our service to the scientific community.

Recent Publications

Last month, the Official Journal of the American Association of Pharmaceutical Scientists published an article online on Development and Validation of ECL Assays.

The article, written by Jennifer Postelnek, Robert J. Neely,Michael D. Robbins, Carol R. Gleason, Jon E. Peterson, and Steven P. Piccoli, was copublished with The American Association of Pharmaceutical Scientists, and was written in our home state of New Jersey.

Development and Validation of Electrochemiluminescence Assays to Measure Free and Total sSLAMF7 in Human Serum in the Absence and Presence of Elotuzumab

We are proud to say these scientists were able to utilize Novoprotein’s SLAMF7 product (Catalog No. C316) to test this. We have a variety of SLAM family proteins open for all researchers to try, and if that’s not enough, we have our custom product services where we can tailor proteins to your order. Just imagine what you can do.

Come join us for the Annual Bristol-Meyers Squibb Research & Development Symposium! With over 2200 of your colleagues, let us share in a wide range of Presentations, Discussions, Posters, Poster Presentations, Awards and Networking Activities.

Doubletree Hotel and Garden State Exhibit Center

In the Doubletree Hotel and Garden State Exhibit Center, here in Somerset New Jersey, join us and 100 of our fellow exhibitors in fully and personally meeting and interacting with members from BMS; as such we invite you to personally meet our staff as well! We look forward to meeting all of you.

Sleepless in Seattle

Come join Novoprotein and the American Association of Immunologists (AAI) at the 11th Annual Meeting. This year, it will be in Seattle, WA. For those of you who went to New Orleans with us last year, or to Pittsburgh in 2014, you know the AAI Annual Meeting is a massive, global event. Members of the international scientific community join together as they have year after year.

For over 100 years, The American Association of Immunologists has provided the world’s leading forum for advancing the field of immunology, fostering the interchange of ideas and information among investigators, and addressing the potential integration of immunologic principles into clinical practice. AAI serves its nearly 8,000 members through The Journal of Immunology, the AAI annual meeting, AAI summer courses, awards/grants programs, and career development programs.

Washington State Convention Center

With over 200,000 square feet of Exhibit Hall floor and a Banquet fit for 10,000 people, come walk freely among some of the biggest names in the industry.

Come see the AAI president Dan R. Littman from the New York University School of Medicine, or see Monday’s Symposium Host Immune Responses to Viruses, featuring such guest speakers as Adolfo Garcia-Sastre and his Regulation of innate immune pathways during RNA virus infections, Akiko Iwasaki and her Antiviral immune responses at mucosal surfaces, Louis J. Picker and CD8+ T cell recognition of cytomegalovirus: who is in charge?, and E. John Wherry with Development and reversal of T cell exhaustion.

Booth 2606

Come visit us at our booth, where you can come meet some of our company representatives including our Vice President, Dr. Yufang Shao, and come join your colleagues from over 40 countries in seeing our products and services! We will be stocked with catalogues and other information for you and your companies.

If you visit our booth and have been a longtime customer, please introduce yourself! We love to meet the people we work with, so we can have a more personable relation. If you are new to Novoprotein, introduce yourself as well, and sign up for our newsletter if you haven’t already. Also, qualifying guests may even walk away with Novoprotein gear!

More than just a convention

Beyond the great science, adventure awaits you in Seattle, the uniquely cosmopolitan yet casual port city set spectacularly between Puget Sound and the Cascade Mountains. Experience the vibrant energy of the city’s Downtown—Pike Place Market, Benaroya Hall, great restaurants, and lively entertainment scene. Whether your musical taste is for Puccini or Pearl Jam, you’ll find it in Seattle. And at IMMUNOLOGY 2016, located in the beautiful Washington State Convention Center, you’ll enjoy access to it all. Join us there!

1800+ Products

Since 2004, Novoprotein production has completed over 3000 custom projects, and have completed over 1800 individual products with a 85% success rate.

With major global players for customers such as AstraZeneca, a global, science-led bio-pharmaceutical business and our innovative medicines are used by millions of patients worldwide; Novartis, a global healthcare company based in Switzerland that provides solutions to address the evolving needs of patients worldwide; Merck, which discovers, develops, manufactures and markets prescription human and veterinary medicines, and consumer healthcare products; and Bristol-Myers Squibb, a global bio-pharmaceutical company whose mission is to discover, develop and deliver innovative medicines, you can rest comfortably knowing the quality of our products and services are held to the highest of standards.

Many Opportunities

You can order our products directly from us; by phone, email, or fax. Simply go to our website to place an order, or call our sales number at 973-671-8010. If you don’t know what product you’re looking for, or what Novoprotein lists the protein as, you can search by protein name on our website’s search bar, before you place your order.

We also use distributors to help deliver around the world. In the United States of America and Canada, we have VWR, Fisher Scientific, and Cedarlane. For Europe, there is PELOBiotech, Holzel Diagnostika, CliniSciences, and Gentaur. For Australia, there is LifeResearch. Asia has Cosmo in Japan, and iCell in South Korea.

You can find listings for all of our products online, or we have a physical and digital copy of or catalogue. You can request one here, or download it as a .pdf