In Kyu YoonDepartment of Virology, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand University of Massachusetts Medical School, Worcester, Massachusetts Department of Medicine, University of Toronto, Toronto, Ontario, Canada Department of Entomology, University of California, Davis, Davis, California Department of Geography, University at Buffalo, Buffalo, New York Bureau of Epidemiology, Department of Medical Sciences, Ministry of Public Health, Nonthaburi, Thailand Department of Infectious Diseases, State University of New York, Syracuse, Syracuse, New York Institute for Immunology and Informatics, University of Rhode Island, Providence, Rhode Island Fogarty International Center, National Institutes of Health, Bethesda, MarylandAm J Trop Med Hyg 89:1081-7. 2013

..These results suggest that frequent viral migration into Kamphaeng Phet, coupled with population (school) subdivision, shapes the genetic diversity of DENV on a local scale, more so than in situ evolution within school catchment areas...

Department of Defense influenza and other respiratory disease surveillance during the 2009 pandemic

..Here we measure G x G interactions in a system representative of a natural situation in Thailand by challenging three isofemale families from field-derived Aedes aegypti with three contemporaneous low-passage isolates of DENV-1...

..To define the dimensions of local transmission and quantify the factors that support it, we examined relationships between infected humans and Aedes aegypti in Thai villages...

Characteristics of mild dengue virus infection in Thai children

In Kyu YoonDepartment of Virology, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand University of Massachusetts Medical School, Worcester, Massachusetts Department of Medicine, University of Toronto, Toronto, Ontario, Canada Department of Entomology, University of California, Davis, Davis, California Department of Geography, University at Buffalo, Buffalo, New York Bureau of Epidemiology, Department of Medical Sciences, Ministry of Public Health, Nonthaburi, Thailand Department of Infectious Diseases, State University of New York, Syracuse, Syracuse, New York Institute for Immunology and Informatics, University of Rhode Island, Providence, Rhode Island Fogarty International Center, National Institutes of Health, Bethesda, MarylandAm J Trop Med Hyg 89:1081-7. 2013

..Mild infections identified by cluster investigations account for a major proportion of all DENV infections. These findings are relevant for disease burden assessments, transmission modeling, and determination of vaccine impact...

..It is unclear whether dengue serotypes differ in their propensity to cause severe disease. We analyzed differences in serotype-specific disease severity in children presenting for medical attention in Bangkok, Thailand...

..Using a selection of these samples, we also found that our ability to detect virus by direct C6/36 cell culture and mosquito inoculation was enhanced by using whole blood but not to the same extent as that seen by the use of RT-PCR...

Monitoring and improving the sensitivity of dengue nested RT-PCR used in longitudinal surveillance in Thailand

..To test the hypothesis that DENV transmission is spatially and temporally focal, we compared geographic and temporal characteristics within Thai villages where DENV are and are not being actively transmitted...

Safety and immunogenicity of a tetravalent live-attenuated dengue vaccine in flavivirus-naive infants

..6% developed tetravalent neutralizing antibodies ≥ 1:10 to DENV (control group = 0%). This vaccine candidate, therefore, warrants continued development in this age group (NCT00322049; clinicaltrials.gov)...

..The results from the WHO swH1 primer and probe set exhibited diverse sensitivities for the 2009 influenza A/H1N1 strains in Southeast Asia (SEA)...

Applications of PCR (real-time and MassTag) and enzyme-linked immunosorbent assay in diagnosis of respiratory infections and diarrheal illness among deployed U.S. military personnel during exercise Balikatan 2009, Philippines

..influenzae and human parainfluenza virus 3; and 2 tested negative. Laboratory-based surveillance can be useful in determining etiologies of diarrheal and respiratory illness of deployed military personnel...

Blood group AB is associated with increased risk for severe dengue disease in secondary infections

..1% of flavivirus-primed subjects were seropositive to antibodies against all four DENV types 1 and 3 months post-TDEN dose 2. The TDEN vaccine was immunogenic with an acceptable safety profile in flavivirus-primed adults. ..

Kinetics of chikungunya infections during an outbreak in Southern Thailand, 2008-2009

..Patents were positive by PCR for a mean of 5.9 days with sustained peak viral load through Day 5. The IgM antibodies appeared on Day 4 and peaked at Day 7 and IgG antibodies first appeared at Day 5 and rose steadily through Day 24...

Hospital-based surveillance of Japanese encephalitis at a tertiary hospital in Manila

..8%, 0.5% and 11.5%, respectively. The highest seroprevalence to hepatitis A was observed in cadets from the southern region of Thailand. Seroprevalence rates to hepatitis A and B were less than in other reported studies in Thailand...

Safety and immunogenicity of a tetravalent live-attenuated dengue vaccine in flavivirus naive children