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Antioxidant and Antifibrotic properties of Green Tea

Tsai et alinvestigated the in vivo antioxidant and antifibrotic properties of Green Tea(Camellia sinensis) with induced oxidative stress and hepatic fibrosis in an animal model study. Green Tea extract at doses of 125, 625 and 1250mg/kg for 8weeks significantly reduced various biomarkers associated with oxidation increased the activities of catalase, glutathione peroxidase (GSH-Px) and glutathione reductase in the liver. This study found that Green Tea extract prevented induced hepatic fibrosis.

Fibrosis: developmental disorder, particularly in the liver, marked by formation of irregular broad bands of fibrous tissue containing multiple cysts and resulting in vascular constriction and portal hypertension. Antifibrotic is any agent which can stop or reverse this condition

In conclusion, these results suggest that Green Tea exhibits powerful protective effects against induced oxidative stress and hepatic fibrosis in an animal model system by inhibiting oxidative damage and increasing antioxidant enzyme activities.