D800 Difference in 8x10 prints

With a D800/D800E will I see the difference in 8x10 and 16x20prints, after some/modest amounts of cropping. I am presently using 20mp Samsung NX cameras with high quality lens (including Contax/Zeiss). I print on an Epson 3880 in high gloss for my 8x10 inch and special matte for 16x20.

The size I print almost always is 8x10 inches with an occasional 16x20 inch. So the question is mostly focused on 8x10 but comments on 16x20 will also be appreciated. From a cropping standpoint, the most I crop is to take a 10 height x 8 width portrait crop out of the image.

Will the D800 standout like a "3D" look or something that is noticeable at close distant on a print or is the printer going to be the limiting factor. Are there other considerations I am missing.

I am really trying to decide if I want to bulk up again to full frame DLSR gear for prosumer level stuff. I had a Canon 5dm2 full kit but sold it all off in December.