Awakening in a top-secret Umbrella operations facility as the T-virus threatens to wipe out the last vestige of humanity, Alice (Milla Jovovich) embarks on a quest to uncover the truth about her mysterious past, and seek out the source of the apocalyptic plague. The deeper Alice ventures into the complex, the more she begins to learn about her origins. Later, after escaping to the outside world, she embarks on an epic adventure that takes her to the furthest corners of the globe while fighting the forces of darkness alongside allies both old and new. Sienna Guillory, Michelle Rodriguez, and Kevin Durand co-star.