03 October 2003: During a performance of Siegfried & Roy's ongoing show at the Mirage Casino, the white tiger Mantecore attacked Roy, latching onto his neck, putting him in hospital where he coded 3 times and needed 25% of his skull removed. In 2013, he remained "a little bit handicapped" by the incident. Mantecore died in 2014 after a short illness.

Obviously, with an animal act, there is always a danger, even/especially after so many years was always a possibility (although not guaranteed), however the coincidence remains. Whether the joke on The Simpsons is now no longer funny - or is even funnier - is left up to the reader.