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OJBTM

Online Journal of Bioinformatics

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Volume 19 (2):181-188, 2018.

In silico prediction of antigenic
epitope of coat protein from soybean dwarf virus.

Gomase VS, Chikhale NJ., In silico prediction
of antigenic epitope of coat protein from soybean dwarf virus, Onl J Bioinform., 19(2):181-188,
2018.Soybean
dwarf virus susceptible host plant show systemic puckering, rugosity
and yellowing of leaves, stunting (Glycine max), systemic leaf reddening
(Trifoliumincarnatum,
T. subterraneum), systemic chlorosis and
yellowing (Viciafaba),
systemic leaf yellowing or reddening (Astragalussinicus). Soybean dwarf virus (SbDV) infection of plant cells causes various diseases. SbDV infection of host cells produces structural and
nonstructural proteins. One of these, the coat protein, is the major protein of
the virion. This protein is believed to play an
important role in a number of processes, including viral attachment, membrane
fusion, and entry into the host cell. Antigenic epitopes on Coat protein
[Soybean dwarf virus] are important determinants of protection against virus
infection to the various plants. As our knowledge of the immune responses to a
protein antigen progressed, it became clear that the whole protein is not
necessary for raising the immune response, but small segments RAPRVQLMAVPTVTS;
SDGILKAYHEYKITSILLQFIT, 20-34; 93-114 of coat protein called the antigenic
determinants or the epitopes are sufficient for eliciting the desired immune
response. In response to soybean dwarf virus infection, the host produces virus
neutralizing antibodies and cytotoxic T cells (CTLs). The principal target for
the neutralizing antibodies is the coat protein. It has been shown that
protection against soybean dwarf virus infection is mainly antibody dependent,
and virus-neutralizing antibodies alone are sufficient to impart. Peptide(s)
from soybean dwarf virus protein that forms the virus-neutralizing epitope(s)
could, therefore, be used for inducing soybean dwarf virus -neutralizing
antibodies.