1. This exercise and this sale were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on 11/12/2012.

2. The price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $17.45 to $17.91. The reporting person undertakes to provide to Santarus, Inc., any security holder of Santarus, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within this range.

3. 1/60 vest monthly from 5/22/2003.

4. Not applicable to this transaction.

Remarks:

/s/ Debra P. Crawford
Attorney-in-fact

04/02/2013

** Signature of Reporting Person

Date

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.

* If the form is filed by more than one reporting person,
see
Instruction
4
(b)(v).