A research on Pubmed, covering a 12-month time period, from January 12, 2008 to November 30, 2009, using the keywords EUS, echo-endoscopy, and endoscopic ultrasound retrieved 684 articles. Restricting to the English and French literatures, selecting only clinical trials performed in humans allowed to lower the number to 108 articles. Selecting a Top 5 is though a cruel task because of several leftover good quality articles. However, five subjects are covered based on the quality and originality of the work and the notoriety of the journal. They are described and commented in this article.