I have the directdr virus and I can't get rid of it. I tried to download combofix but it wouldn't let me because McAfee thought it was a virus. I've tried Malaware Bytes, spybot, and adaware. I also have a firewall and windows defender. It also seems to have only infected on user on my computer. any help is appreciated.

yes, go in safe mode, delete processes that you suspect are malaware from autorun (they usually have strange or difficult names), and scan your system with antivirus.
Use AVZ (http://www.softpedia.com/get/Antivirus/AVZ-Antiviral-Toolkit.shtml [/url] ) to scan your system in the safe mode. It isnt required to be installed on your PC. It can scan your system from disc or USB pen drive. About month ago it helped me a lot when I caught a banner on my PC. It disconnected my antivirus and covered all my screen so I couldnt open any folder I dowloaded avz on my usb pen drive and scanned all the system in the safe mode

If your navigator is reorientated to Directdr.Com or to the sites of different races, it is présumable that the réacheminement is caused by a pirate of navigator that runs on your computer. The pirate of navigator is a persistent Trojan virus that is constructed to modify the reports of Dns and the hosts classify values to reorientate the research circulation to the alternate websites. The virus changes the register, the files of damages and installs other malware on the corrupt computer. This will result that when the users click on google, yahoo or be, the search engine links will be directed to Directdr.Com or to the various superfluous websites. The Directdr.com related malware can prevent from the software anti- virus to detect modifications did to the register and cause the speed of your system to be seriously layered. You can get detailed Directdr.com Removal Instructions from http://www.scanforfree.com/105/directdr-com-removal.html. Hope this site would help you.