Yet Another Antidepressant May Help Treat Anxiety

June 5, 2000 -- Effexor is a relative newcomer to the ever-growing ranks of
antidepressant drugs. Now, researchers have discovered that, like many of the
newer antidepressants, it also may be effective for treating people with
anxiety disorders.

A recent study found that Effexor, in its extended-release form, could help
people with generalized anxiety disorder, one of the most common anxiety
disorders. GAD is a disabling disorder characterized by excessive worry about
many aspects of life. Patients have trouble sleeping, poor concentration, and
experience bodily symptoms like tremors, sweating, and stomach upsets.

Although talking therapies are available, patients who seek help from
doctors are usually treated with either BuSpar (buspirone) or one of the
benzodiazepines, such as Valium and Ativan. While these medications are usually
effective, BuSpar can take a long time to start working, and benzodiazepines
can be unsafe and addictive, so the researchers felt there was a need to find
suitable alternatives.

"The benzodiazepines are better for the very short term -- two to three
weeks -- but many anxious patients need to be treated for longer," study
author Karl Rickels, MD, tells WebMD. "The problem with benzodiazepines is
that they produce dependency in long-term use. So far, we only have buspirone
for the longer term, so it would be good to have another drug that we can
use." Rickels is a professor of psychiatry and chief of the mood and
anxieties disorders section at the University of Pennsylvania.

Effexor, whose generic name is venlafaxine, is among a new class of
antidepressants that act via two different pathways in the brain to counteract
depression. Several studies have shown that an older drug, which acts in a
similar way to Effexor in the body, is effective in treating generalized
anxiety disorder, so the researchers wanted to see if Effexor also would
work.

The study, which was published in the American Journal of Psychiatry,
included 377 participants from across the U.S. For eight weeks, they received
either a placebo or varying doses of Effexor XR. Effexor was found to be
effective in reducing anxiety, and patients taking a dose of 225 mg showed the
most improvement.