The Titans didn't have much luck containing Russell Wilson in their 20-13 loss in Seattle last week. Wilson was able to scramble around and ended up with 61 yards rushing.

Colin Kaepernick will pose the same threat to extend plays and move the chains with his ability to run. The Titans have to keep him contained inside the pocket and force Kaepernick to beat the Titans' cornerbacks, who are playing exceptionally well to this point.

If guys like Jurrell Casey and RopatiPitoitua can put consistent pressure in the face of Kaepernick, that should keep him from piling up the yards.

Being the fiery competitor that Kaepernick is, don't be surprised if he lights up the scoreboard if the Titans defense come out flat.

2. AlterraunVerner (TEN) vs. Anquan Boldin (SF)

Verner is currently having a career-season with four interceptions, and he's doing a solid job matching up with No.1 targets of other teams. He'll probably have a stiff challenge this week against Anquan Boldin, who's a guy that's always capable of making catches in traffic to extend drives.

For the Titans to win this game, it can't turn into a shootout. The score has to stay well below 30 points for the Titans offense to have a shot at pulling this one out. That means Verner will have to continue his hot streak, and maybe even snatch his fifth interception of the year. He's already leading the league in pass breakups with 13, according to ESPN.com.

Who will be the game MVP?

Who will be the game MVP?

Colin Kaepernick (SF)

11.8%

Frank Gore (SF)

14.5%

Vernon Davis (SF)

6.5%

Patrick Willis (SF)

1.6%

Ryan Fitzpatrick (TEN)

2.4%

Chris Johnson (TEN)

24.7%

Someone else

38.4%

Total votes: 372

A number of different players could end up getting the tough assignment of covering Vernon Davis, but George Wilson makes the most sense. He's got all of the tools to keep Davis from catching another deep throw from Colin Kaepernick and changing the complexion of the game in a flash.

The secondary for the Titans is probably the biggest improvement on this team from last season. They're playing that style of defense that bends but doesn't break. If they keep it low scoring, then they'll give the offense a chance. That means shutting down Davis if you're Wilson, or any other Titans defender that may be lucky enough to defend him.

4. Ryan Fitzpatrick (TEN) vs. 49ers secondary

We've clearly seen why Ryan Fitzpatrick was let go by the Buffalo Bills and became the backup quarterback to Jake Locker in Tennessee. He shows quick flashes of having a strong arm, but his accuracy has been way off in two starts for the Titans.

It won't get any easier for Fitzpatrick against the 49ers secondary that is forcing plenty of turnovers right now. He has to manage this game better than he has over the last two games and use Delanie Walker against his former team.

Walker has shown that he can be a reliable receiving tight end in mid-range throws, and that's what Fitzpatrick needs to look towards to get his confidence up a little bit.

If the Titans running game could improve, then that would also do wonders for Fitzpatrick's chances of maybe putting together a decent performance.

With that said, look for Willis to be putting all types of pressure on Johnson right at the line of scrimmage. It will be Johnson's tough assignment to make the first guy miss and try to find some open space, where he is so lethal.

If Johnson can find a way to claw to 50 to 60 yards, then it may give the Titans' passing attack a chance to string together some extended drives. That will be no easy task.