Discussions By Condition: I cannot get a diagnosis.

Duchenne Muscular dystrophy

can anyone tell me if my dad has been advised he does not have this x link recessive disease, does that automatically mean his daughters (ie me) can NOT carry the disease? Its just I read if you had an uncle with DMD (which I did), I too could be at risk, which is then confusing! Does anybody know the truth?

2 Replies:

can anyone tell me if my dad has been advised he does not have this x link recessive disease, does that automatically mean his daughters (ie me) can NOT carry the disease? Its just I read if you had an uncle with DMD (which I did), I too could be at risk, which is then confusing! Does anybody know the truth?If your uncle had the disease, and he was your father's brother, and your father does not have the disease, then your risk of having the disease (or carrying the mutation) is not higher than it would be in the general population.If your uncle was your mother's brother, though, there would be 50% chance that she had the mutation, and thus there would be some chance you would carry the mutation without knowing it.

can anyone tell me if my dad has been advised he does not have this x link recessive disease, does that automatically mean his daughters (ie me) can NOT carry the disease? Its just I read if you had an uncle with DMD (which I did), I too could be at risk, which is then confusing! Does anybody know the truth?You can only inherit dmd from your mother, not your father, so his diagnosis is irrelevant. The article was probably referring to a maternal uncle.Having said that it would be prudent to consult a geneticist if you are planning to have kids.Ian