DYSPEPSIA and MEPROBAMATE

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DYSPEPSIA Symptoms and Causes

Nearly everyone has had indigestion at one time. It's a feeling of discomfort or a burning feeling in your upper abdomen. You may have heartburn or belch and feel bloated. You may also feel nauseated, or even throw up.

You might get indigestion from eating too much or too fast, eating high-fat foods, or eating when you're stressed. Smoking, drinking too much alcohol, using some medicines, being tired, and having ongoing stress can also cause indigestion or make it worse. Sometimes the cause is a problem with the digestive tract, like an ulcer or GERD.

Avoiding foods and situations that seem to cause it may help. Because indigestion can be a sign of a more serious problem, see your health care provider if it lasts for more than two weeks or if you have severe pain or other symptoms. Your health care provider may use x-rays, lab tests, and an upper endoscopy to diagnose the cause. You may need medicines to treat the symptoms.

DYSPEPSIA Clinical Trials and Studies

Treatments might be new drugs or new combinations of drugs, new surgical procedures or devices, or new ways to use existing treatments. The goal of clinical trials is to determine if a new test or treatment works and is safe. Clinical trials can also look at other aspects of care, such as improving the quality of life for people with chronic illnesses. People participate in clinical trials for a variety of reasons. Healthy volunteers say they participate to help others and to contribute to moving science forward. Participants with an illness or disease also participate to help others, but also to possibly receive the newest treatment and to have the additional care and attention from the clinical trial staff.

Treatment success : The HKDI is less than 16. Treatment was considered to have failed if a patient had taken medication for Dyspepsia (other than antacids) during the study period; Treatment success: no significant Dyspepsia defined by the Global Dyspepsia Score

To assess the effect of Itopride on Gastric Emptying,accommodation and capacity of tolerating a nutrient drink in patients with Functional Dyspepsia; To assess the effect of Itopride on symptom improvement in patient with Functional Dyspepsia

Children with FD: exploration of relationships between ghrelin concentration, liquid gastric emptying, and Dyspepsia subtype; Children with FD: SUBJECTIVE SYMPTOM SEVERITY and correlations between plasma ghrelin concentrations (acyl and desacyl) and gastric emptying.

The primary outcome will be the adequacy of symptom control during the last week of the study.; Secondary outcomes equate Dyspepsia symptoms with quality of life. The Nepean Dyspepsia Index scores patients on five categories while the Global Overall Symptom Scale measures the severity of Dyspepsia on a 1-7 scale.

The primary outcome measure is the proportion of patients who report positive response to adequate relief of dyspeptic symptoms at week 8.; The secondary outcome measures include dyspeptic symptom scores, symptom association probability of dyspeptic symptoms in relation to esophageal pH of less than 4 as measured at 1 cm above SCJ.

To evaluate the change of serotonin and ghrelin level in blood plasma before and after treatment; To measure expression of serotonin and ghrelin blood plasma, the rate of adequate relief using global symptom assessment, symptom scores and the fullness rating of the Fullness Rating Scale (FRS) during satiety test

If you think you may have a medical emergency, call your doctor or 911 immediately.

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