ibuprofen and oxycodone

What is the most important information I should know about ibuprofen and oxycodone?

Oxycodone can slow or stop your breathing, and may be habit-forming. MISUSE OF NARCOTIC MEDICINE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH, especially in a child or other person using the medicine without a prescription.

Taking this medicine during pregnancy may cause life-threatening withdrawal symptoms in the newborn.

Fatal side effects can occur if you use this medicine with alcohol, or with other drugs that cause drowsiness or slow your breathing.

Ibuprofen can increase your risk of fatal heart attack or stroke, especially if you use it long term or take high doses, or if you have heart disease. Do not use this medicine just before or after heart bypass surgery (coronary artery bypass graft, or CABG).

Ibuprofen may also cause stomach or intestinal bleeding, which can be fatal. These conditions can occur without warning while you are using ibuprofen, especially in older adults.

What is ibuprofen and oxycodone?

Oxycodone is an opioid pain medication, sometimes called a narcotic. Ibuprofen is a nonsteroidal anti inflammatory drug (NSAID). This medicine works by reducing substances in the body that cause pain, fever, and inflammation.

Ibuprofen and oxycodone is a combination medicine used short-term to relieve severe pain. This medication is not for treating arthritis pain.

Ibuprofen and oxycodone may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking ibuprofen and oxycodone?

Ibuprofen can increase your risk of fatal heart attack or stroke, especially if you use it long term or take high doses, or if you have heart disease. Even people without heart disease or risk factors could have a stroke or heart attack while taking ibuprofen and oxycodone.

Ibuprofen may also cause stomach or intestinal bleeding, which can be fatal. These conditions can occur without warning while you are using this medicine, especially in older adults.

You should not use this medicine if you are allergic to ibuprofen (Advil, Motrin) or oxycodone, or if you have ever had an asthma attack or severe allergic reaction after taking aspirin or an NSAID. Do not use this medicine just before or after heart bypass surgery (coronary artery bypass graft, or CABG).

To make sure this medicine is safe for you, tell your doctor if you have ever had:

heart disease, high blood pressure, high cholesterol, diabetes, or if you smoke;

a heart attack, stroke, or blood clot;

a stomach ulcer or stomach bleeding;

any type of breathing problem or lung disease;

liver or kidney disease;

fluid retention;

a head injury, brain tumor, or seizures;

a thyroid or adrenal gland disorder;

urination problems; or

alcoholism, drug addiction, mental illness.

Some medicines can interact with oxycodone and cause a serious condition called serotonin syndrome. Be sure your doctor knows if you also take stimulant medicine, herbal products, or medicine for depression, mental illness, Parkinson's disease, migraine headaches, serious infections, or prevention of nausea and vomiting. Ask your doctor before making any changes in how or when you take your medications.

Taking ibuprofen during the last 3 months of pregnancy may harm the unborn baby. If you use oxycodone while you are pregnant, your baby could become dependent on the drug. This can cause life-threatening withdrawal symptoms in the baby after it is born. Babies born dependent on habit-forming medicine may need medical treatment for several weeks.

This medicine can pass into breast milk and cause drowsiness or breathing problems in a nursing baby. Tell your doctor if you are breast-feeding.

How should I take ibuprofen and oxycodone?

Follow all directions on your prescription label. Oxycodone can slow or stop your breathing. Never take ibuprofen and oxycodone in larger amounts, or for longer than prescribed. Use the lowest dose that is effective in treating your condition. Tell your doctor if the medicine seems to stop working as well in relieving your pain.

Oxycodone may be habit-forming, even at regular doses. Never share this medicine with another person, especially someone with a history of drug abuse or addiction. MISUSE OF NARCOTIC MEDICINE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH, especially in a child or other person using the medicine without a prescription. Selling or giving away ibuprofen and oxycodone is against the law.

If you need surgery, tell the surgeon ahead of time that you are using ibuprofen and oxycodone.

Store at room temperature away from moisture and heat. Keep track of your medicine. Oxycodone is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription.

Do not keep leftover opioid medication. Just one dose can cause death in someone using this medicine accidentally or improperly. Ask your pharmacist where to locate a drug take-back disposal program. If there is no take-back program, flush the unused medicine down the toilet.

What happens if I miss a dose?

Since this medicine is used for pain, you are not likely to miss a dose. Skip any missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. A oxycodone overdose can be fatal, especially in a child or other person using the medicine without a prescription. Overdose symptoms may include vomiting, black or bloody stools, coughing up blood, confusion, muscle weakness, cold and clammy skin, slow heart rate, blue lips, very slow breathing, or coma.

What should I avoid while taking ibuprofen and oxycodone?

This medication may impair your thinking or reactions. Avoid driving or operating machinery until you know how the medicine will affect you. Dizziness or severe drowsiness can cause falls or other accidents.

Do not drink alcohol. Dangerous side effects or death could occur.

Ask a doctor or pharmacist before using any cold, allergy, or pain medication. Many combination medicines contain aspirin or other medicines similar to ibuprofen. Taking certain products together can cause you to get too much of this type of medicine.

What are the possible side effects of ibuprofen and oxycodone?

Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling).

Get emergency medical help if you have signs of a heart attack or stroke: chest pain spreading to your jaw or shoulder, sudden numbness or weakness on one side of the body, slurred speech, leg, swelling, feeling short of breath.

Stop using this medicine and call your doctor at once if you have:

weak or shallow breathing, sighing, slow heartbeat;

swelling or rapid weight gain;

the first sign of any skin rash, no matter how mild;

signs of stomach bleeding --bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;

This list is not complete. Other drugs may interact with ibuprofen and oxycodone, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Where can I get more information?

Your pharmacist can provide more information about ibuprofen and oxycodone.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

This information does not replace the advice of a doctor. Healthwise, Incorporated disclaims any warranty or liability for your use of this information. Your use of this information means that you agree to the Terms of Use and Privacy Policy. Learn how we develop our content.

Healthwise, Healthwise for every health decision, and the Healthwise logo are trademarks of Healthwise, Incorporated.