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Objectives: To determine if the structure and centrality of the religious/spiritual construct system are associated with personality dimensions and psychopathological symptoms and to make clear any differences between addiction patients, general psychiatric patients and healthy controls? Methods: In total 420 people of both sexes were included in the study. Religiosity and spirituality were investigated in clinically characterised detoxified addicts (N=120), depressive in-patients (N=100), and persons with no psychiatric diagnosis or treatment in their history (N=200) using the Multidimensional Inventory for Religious/Spiritual Well-Being (MI-RSWB 48) in combination with the Centrality Scale (C-Scale) and the Structure of Religiosity Test (SRT). Personality dimensions were investigated using the Six Factors of Personality Test (6F Test). For psychiatric patients, the psychopathological dimensions were assessed using the Brief Symptom Inventory (BSI), the Beck Depression Inventory (BDI), the Brief Psychiatric Rating Scale (BPRS) and the Montgomery Asberg Depression Rating Scale (MADR-S). Data were evaluated with χ2 Test and correlation/regression analysis. General linear model multivariate (parametric) was conducted for multiple group comparisons. Results: Women were shown to be more religious/spiritual than men and there was a positive association between religiosity/spirituality and age. Depressive patients turned out to be the most religious-spiritual and addicts the least. The personality dimensions piety, extraversion and openness showed to be positive predictors of religiosity/spirituality whereas neuroticism and aggressiveness were found to be negative predictors. Psychopathological symptoms were the strongest negative predictors of hope and forgiveness as religious/spiritual dimensions. The more central the individual religious/spiritual construct system is, the more powerful are its effects. Conclusion: There is a relevant mutual association between religiosity/spirituality, personality, and psychopathological symptoms dependent on the centrality of the individual religious/spiritual construct system. The integration of religious/spiritual issues could open up new strategies in diagnosis, prevention, and treatment of psychiatric diseases.