Who Are the Frontrunners to Win Big at the Golden Globe Awards?

GoldDerby.com's Tom O'Neil gave ET the ultimate cheat sheet for the Golden Globe Awards, complete with the odds-on favorites in the major categories.

Best Performance by an Actor in a Motion Picture, Drama: Leonardo DiCaprio already has two Golden Globe Awards, but fellow nominees Bryan Cranston and Will Smith could ruin his chances at a third. "If either one of them pulls off an upset that could trip up Leo winning the Oscar," O'Neil said. "The Globes predict the Oscars about 75 percent of the time. That means Leo absolutely needs to win at the Globes if he's finally going to catch up with Oscar."

Best Motion Picture, Drama: Spotlight seems to be ahead of the pack, but it's not a shoo-in. "Mad Max or The Revenant could pull off an upset, because voters often like to go for the big picture in terms of epic."

Best Performance by an Actress in a Motion Picture, Musical or Comedy: This is by far the most entertaining race to watch, as BFFs Amy Schumer and Jennifer Lawrence go toe-to-toe for the gold. "The comedy actress race pits the coolest cat in Hollywood against the biggest movie star in the world," O'Neil said. "We bet on Amy to win because even Jennifer is rooting for her."

Best Performance by an Actress in a Motion Picture, Drama: O'Neil puts Brie Larson at the front of this race for her performance in Room and her work ethic. "It's a good thing that Brie also appears in Trainwreck, because the more movies you appear in in one year, the better it is for your award chances."

Best Performance by an Actress in a Motion Picture, Musical or Comedy:The Martian has faced backlash for being nominated in the comedy category, but O'Neil says a bet on Matt Damon is close to a sure thing, regardless. "Matt Damon has never won a major Hollywood award for acting. He's won for writing, but he's overdue finally to be recognized as a performer, and it will happen at the Globes,” he explained.

The 2016 Golden Globes, hosted by Ricky Gervais, will air live on Sunday, Jan. 10, at 8 p.m. ET/ 5 p.m. PT on NBC.