{"id":18173,"version":3,"created":1555009204000,"modified":1555009349000,"deprecated":false,"name":"5-hydroxytryptamine receptor 1D","accession":"P28221","gene":"HTR1D","description":"G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Regulates the release of 5-hydroxytryptamine in the brain, and thereby affects neural activity. May also play a role in regulating the release of other neurotransmitters. May play a role in vasoconstriction.","idgFamily":"GPCR","idgTDL":"Tclin","novelty":-2.543278780305916,"antibodyCount":140,"monoclonalCount":3,"pubmedCount":null,"jensenScore":350.777201,"patentCount":8267,"grantCount":null,"grantTotalCost":null,"r01Count":null,"ppiCount":null,"knowledgeAvailability":30.578146957802126,"pubTatorScore":2.2670756213124132,"kind":"ix.idg.models.Target","self":"https://pharos.nih.gov/idg/api/v1/targets(18173)?view=full","_organism":null,"_synonyms":{"count":118,"href":"https://pharos.nih.gov/idg/api/v1/targets(18173)/synonyms"},"_publications":{"count":53,"href":"https://pharos.nih.gov/idg/api/v1/targets(18173)/publications"},"_properties":{"count":288,"href":"https://pharos.nih.gov/idg/api/v1/targets(18173)/properties"},"_links":{"count":1548,"href":"https://pharos.nih.gov/idg/api/v1/targets(18173)/links"},"_namespace":null}