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WASHINGTON (AP) — The U.S. and Russia will drastically reduce their nuclear arsenals under a historic treaty to be signed next month.

After long and trying negotiations, President Barack Obama and Russian President Dmitry Medvedev are to sign the treaty in two weeks in Prague, once final technical details are worked out, officials in Washington and Moscow said Wednesday. The accord is expected to cut the number of long-range nuclear weapons held by each side to about 1,500, and it raises hopes for further disarmament in the years ahead.

The deal is seen as sealing an increased level of trust and cooperation between the U.S. and Russia, who possess the vast majority of the world’s nuclear arms and have labored under strained relations in recent years.

Obama and Medvedev are expected to seal the deal when they talk by telephone this week, setting the stage for a White House campaign to win Senate ratification. The treaty also must win approval by the Russian Duma, and the two legislative processes are likely to take months.

Robert S. Norris, a longtime analyst of U.S. and Russian nuclear arsenals, said Senate ratification would not be easy.

“Hard negotiations with the Russians will now be followed by hard negotiations with Republican senators to achieve ratification,” Norris said.

Though the State Department said the two countries were still working out unspecified final technical details, spokesman Mark Toner said there had been discussions with the Czech government about holding a signing ceremony in Prague — where Obama last April declared his vision of a nuclear-free world.

In fact, Czech officials announced that Prague would host the signing. They did not give a date, but Russian and U.S. officials said it was expected to be April 8.

The new agreement to reduce long-range nuclear weapons would replace the 1991 Strategic Arms Reduction Treaty, which expired in December. An important feature of the new deal is that it includes a legal mechanism for verifying that each side complies — an element that was absent from a 2002 deal, known as the Moscow Treaty, that accelerated the weapons reductions laid out in the 1991 treaty.

The Moscow Treaty set limits on both sides’ strategic nuclear warheads at between 1,700 and 2,200. The new deal, whose provisions have not been made public, is expected to lower that to about 1,500. It also would reduce the permissible number of strategic launchers — the missiles and bombs that deliver warheads to their targets.

Obama spent an hour Wednesday in the White House briefing Democratic Sen. John Kerry, chairman of the Senate Foreign Relations Committee, and Sen. Richard Lugar, the committee’s ranking Republican. Both would play major roles in ratification of the emerging treaty.

Kerry said he and Lugar would hold hearings to examine the details.

“A well-designed treaty will send an important message to the rest of the world that America is prepared to lead efforts with key stakeholders to reduce the threat of nuclear weapons,” Kerry said.

Two senior U.S. officials in Washington said the technical issues still to be resolved were in an “annex” to the main treaty, and they foresaw no hurdles to completing the entire deal within days. They spoke on condition of anonymity due to the sensitive discussions. One official said an announcement that the treaty is complete is expected by Friday.

A Kremlin source, speaking by telephone to The Associated Press, said all the documents, including the treaty, had been agreed upon. Russian Foreign Minister Sergey Lavrov said last week that the treaty was 20 pages long, with an extensive protocol attached.

Negotiations, which have been under way in Geneva since last spring, became bogged down in recent months on disputes over verification measures and Russia’s objection to U.S. missile defense plans for Europe.

Russian negotiators have balked at including some intrusive weapons verification measures in the new treaty. The Obama administration has warned that without these, Senate ratification could prove difficult.

The agreement would still leave each country with a large number of nuclear weapons, both deployed and stockpiled.

Norris, the nuclear weapons expert, and Hans M. Kristensen of the Federation of American Scientists estimate that the U.S. has 2,150 deployed strategic nuclear weapons and the Russians have about 2,600. The U.S. has another 2,600 warheads held in reserve, plus 500 non-strategic nuclear weapons, by the two experts’ estimate. Another 4,200 retired U.S. strategic warheads are awaiting dismantlement.