Rotor syndrome

Common Name(s)

Rotor syndrome

Rotor syndrome is a hereditary disorder of bilirubin metabolism. In Rotor syndrome there is an increase in the amount of bilirubin in the blood (hyperbilirubinemia). Rotor syndrome is characterized by jaundice, which is a yellowing of the skin and whites of the eyes. Rotor syndrome is caused by mutations in the SLCO1B1 and SLCO1B3 genes. Mutations in both genes are required for the condition to occur. This condition is inherited in an autosomal recessive fashion.

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Advocacy and Support Organizations

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Finding the right clinical trial for Rotor syndrome can be challenging. However, with TrialsFinder (which uses the Reg4ALL database and privacy controls by Private Access), you can permit researchers to let you know opportunities to consider - all without revealing your identity.

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Rotor syndrome" returned 4 free, full-text research articles on human participants.
First 3 results:

There has been increasing recognition that organic anion transporter proteins (OATPs) play an important role in the biology of various cancers. De novo expression of OATPs has been identified in breast, colon, pancreatic, gastric and prostate cancer cells, among others. In patients ...

Bilirubin, a breakdown product of heme, is normally glucuronidated and excreted by the liver into bile. Failure of this system can lead to a buildup of conjugated bilirubin in the blood, resulting in jaundice. The mechanistic basis of bilirubin excretion and hyperbilirubinemia syndromes ...

Rotor syndrome is a rare, benign familial disorder characterized by chronic fluctuating, nonhemolytic and predominantly conjugated hyperbilirubinemia with normal hepatic histology. In contrast to Dubin-Johnson syndrome, there is no liver pigmentation in Rotor syndrome. A 36-year-old ...

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Rotor syndrome" returned 0 free, full-text review articles on human participants.

No free, full-text review articles on human participants are available at this time.
Please click this link to visit the PubMed website for results on "Rotor syndrome".

According to ClinicalTrials.gov there are currently 0 additional "open" studies for "Rotor syndrome" (open studies are recruiting volunteers) and 0 "Rotor syndrome" studies with "all" status. Visit ClinicalTrials.gov now to view them. Or alternatively, consider TrialsFinder for assistance:

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Finding the right clinical trial for Rotor syndrome can be challenging. However, with TrialsFinder (which uses the Reg4ALL database and privacy controls by Private Access), you can permit researchers to let you know opportunities to consider - all without revealing your identity.