The Dodgers started playing in Los Angeles in 1958, after moving from Brooklyn.[5] The first Opening Day game for the Dodgers in Los Angeles was played in San Francisco against the San Francisco Giants on April 15, 1958.[3] California native Don Drysdale was the Dodgers' Opening Day starting pitcher that day, in a game the Dodgers lost 8–0.[3][6] Dodgers starting pitchers won both of their Opening Day starts in their first home ballpark in Los Angeles, Los Angeles Memorial Coliseum. Their Opening Day record in their current home park, Dodger Stadium, which opened in 1962, is ten wins, ten losses and six no decisions. That gives the Los Angeles Dodgers' Opening Day starting pitchers a total home record of twelve wins, ten losses and six no decisions. Their record in Opening Day road games is 10 wins, 14 losses and 2 no decisions.[3][4]

Drysdale would make seven Opening Day starts for the Dodgers between 1958 and 1969, a team record he shares with Don Sutton who accumulated them from 1972 through 1978.[3]Fernando Valenzuela, Ramón Martínez, Clayton Kershaw and Orel Hershiser have had at least four Opening Day starts, with six, five, five and four respectively.[3] Hall of Famer Sandy Koufax, who won three Cy Young Awards during the 1960s, only made one Opening Day start for the Dodgers, in 1964.[3][7] Drysdale also holds the Los Angeles Dodgers record for most wins as an Opening Day starter, with five wins against two losses. Sutton has four wins and two losses, and one no decision.[3]

Kershaw (2011, 2013, 2014), Koufax (1964), Chan Ho Park (2001), Brad Penny (2008) and Hiroki Kuroda (2009) are the only Los Angeles Dodgers Opening Day starting pitchers to have won all their Opening Day decisions, Martinez and Derek Lowe share the Los Angeles Dodgers record for most Opening Day losses, with three.[3] The Los Angeles Dodgers won the World Series championship in 1959, 1963, 1965, 1981 and 1988. Drysdale (1959, 1963 and 1965), and Fernando Valenzuela (1981 and 1988) were the Dodgers' Opening Day starting pitchers those years.[3] The Dodgers' starting pitcher won the Opening Day game in 1963, 1965 and 1981, but lost in 1959 and 1988.[8][9][10][11][12]