The group uses cryo-electron microscopy to determine the structure of amyloid proteins
and is developing computational methods for modeling and refinement of
protein structures using low resolution or sparse experimental data. The focus
is on the integration of structure prediction approaches with experimental data
from different sources such as single particle cryo-EM, X-ray crystallography and NMR.
We are working on the prediction of local structural details using molecular dynamics
simulation techniques to improve low-resolution model building and homology modeling.
The goal is to reliably describe the structure and conformational dynamics
of proteins from low or intermediate resolution data.