Pyruvate Side Effects, Interactions and Warnings

The mechanism of action is unclear, but available data suggest that the increase in performance following pyruvate-dihydroxyacetone supplementation may be a result of an increased reliance on blood glucose, thus sparing muscle glycogen. In summary, chronic supplementation of pyruvate-dihydroxyacetone may be beneficial from a preventive medicine prospective as well as for certain athletic endeavors.- Med Sci Sports Exerc 1998 Jun;30(6):837-43 -- Effect of pyruvate and dihydroxyacetone on metabolism and aerobic endurance capacity. -- Ivy JL.

Supplements such as pyruvate have been shown to be effective at high dosages, but there is little mechanistic information to explain its purported effect or data to indicate its effectiveness at lower dosages. Pyruvate hasn't been tested for their effectiveness or safety over prolonged periods of time.- Can J Appl Physiol 2000 Dec;25(6):495-523 -- Dietary fat intake, supplements, and weight loss. -- Dyck DJ.