The findings of a new observational study supports a link between long-term dutasteride (5 alpha reductase inhibitor or 5-ARI) use and adverse sexual side effects, including worsening ED and reduced testosterone levels.

According to the author Abdulmaged M. Traish, MBA, PhD, of Boston University School of Medicine told Renal & Urology News. “The increase in blood glucose and A1C may predispose men to diabetes and the increase in lipids may predispose them to NAFLD [non-alcoholic fatty liver disease]. Most importantly, this agent worsens sexual function and reduces quality of life.”

Based on collected data, Dr. Traish and his colleagues found that dutasteride significantly improved LUTS over 36 to 42 months, according to results published in Hormones Molecular Biology and Clinical Investigations. It reduced prostate volume, International Prostate Symptom Score, and PSA. However, its use was also associated with increased blood glucose, hemoglobin A1c, triglycerides, and low-density lipoprotein levels over the long term. In addition, dutasteride appeared to increase liver transaminase activity and Aging Male Symptom score, which indicates inflammation and reduced quality of life.