Denis Hainehttps://denishaine.ca/
Recent content on Denis HaineHugo -- gohugo.iodenis.haine@gmail.comdenis.haine@gmail.comWed, 02 Jan 2019 00:00:00 +0000Partial prediction of the duration and the clinical status of Staphylococcus aureus bovine intramammary infections based on the phenotypic and genotypic analysis of isolateshttps://denishaine.ca/publication/sa_prediction/
Wed, 02 Jan 2019 00:00:00 +0000denis.haine@gmail.comhttps://denishaine.ca/publication/sa_prediction/Staphylococcus aureus is a bacterial pathogen causing bovine intramammary infections (IMIs) often leading to chronic clinical or subclinical mastitis. Predicting the outcome of S. aureus IMIs (duration and clinical vs subclinical) based on the characterization of isolates would help to make better case management decisions. For this purpose, 583 S. aureus isolates from series of quarter milk samples were characterized by genotypic tests (detection of virulence genes seg, tst, lukM), epidemiological typing (spa type) and by a phenotypic test (biofilm production).New in episensr 0.9.3 - E-valuehttps://denishaine.ca/blog/episensr-vdw/
Sat, 22 Dec 2018 00:00:00 +0000denis.haine@gmail.comhttps://denishaine.ca/blog/episensr-vdw/New version of episensr available on CRAN! In the same vein than the other new function based on the work from Schneeweiss, this new version allows the computation of the E-value as proposed by VanderWeele and Ping, 2017.
The E-value is the minimum strength of association, on the risk ratio scale, that an unmeasured confounder would need to have with both the treatment and the outcome to fully explain away a specific exposure-outcome association, conditional on the measured covariates.New in episensr 0.9.3 - Array approach for unmeasured confoundershttps://denishaine.ca/blog/episensr-schneeweiss/
Fri, 21 Dec 2018 00:00:00 +0000denis.haine@gmail.comhttps://denishaine.ca/blog/episensr-schneeweiss/New version of episensr available on CRAN! Besides now being easier to run multiple bias analysis, this new version offers the option to check the effect of residual confounding based on the array approach (Schneeweiss, 2006).
Even after controlling for confounding (in the design or analysis of a study), some residual confounding can still be present, because:
some confounding factors were not taken into account (not looked at, not adjusted for, or no data collected about them), you only losely took into account that confounding (still presence of differences between groups after control by matching for example, or you lost precision on a confounding variable e.New in episensr 0.9.3 - Multiple bias analysishttps://denishaine.ca/blog/episensr-multi/
Fri, 21 Dec 2018 00:00:00 +0000denis.haine@gmail.comhttps://denishaine.ca/blog/episensr-multi/New version of episensr available on CRAN! Now you can more easily run multiple bias analysis. Very often, epidemiologic studies suffer from multiple biases. Up to now, it took a bit of “manipulation” to apply a sequence of bias function from episensr. So here’s the function multiple.bias that allows to pipe corrected 2-by-2 table from one bias function to an other.
Let’s take for example the study from Chien et al, 2006 looking at the association between antidepressant use (AD) and breast cancer (BC):Milk prices in Canada, U.S.A., New Zealand, and Europehttps://denishaine.ca/blog/milkprice/
Tue, 31 Jul 2018 00:00:00 +0000denis.haine@gmail.comhttps://denishaine.ca/blog/milkprice/As an exercise for Coursera Data Science Specialization I&rsquo;m presently taking, I had to develop a Shiny app with the aim to visualize data. For this, I wanted to look at milk prices, farm gate and retail, in Canada and for various countries. The Shiny app can be found at https://dhaine.shinyapps.io/milkPrice/.
I collected data from Canada, U.S.A., New Zealand, and the EU (EU 15: Belgium, France, Spain, Ireland, Portugal, Germany, Luxembourg, United Kingdom, the Netherlands, Denmark, Austria, Sweden, Italy, Finland, and Greece; EU 28: the aforementioned countries plus the Czech Republic, Estonia, Cyprus, Latvia, Lithuania, Hungary, Malta, Poland, Slovenia, Slovakia, Bulgaria, Romania, and Croatia).Selection and misclassification biases in longitudinal studieshttps://denishaine.ca/publication/bias_longitudinal/
Mon, 28 May 2018 00:00:00 +0000denis.haine@gmail.comhttps://denishaine.ca/publication/bias_longitudinal/Using imperfect tests may lead to biased estimates of disease frequency and measures of association. Many studies have looked into the effect of misclassification on statistical inferences. These evaluations were either within a cross-sectional study framework, assessing biased prevalence, or for cohort study designs, evaluating biased incidence rate or risk ratio estimates based on misclassification at one of the two time-points (initial assessment or follow-up). However, both observations at risk and incident cases can be wrongly identified in longitudinal studies, leading to selection and misclassification biases, respectively.Herd-level mastitis-associated costs on Canadian dairy farmshttps://denishaine.ca/publication/eco_mastitis/
Mon, 14 May 2018 00:00:00 +0000denis.haine@gmail.comhttps://denishaine.ca/publication/eco_mastitis/Mastitis imposes considerable and recurring economic losses on the dairy industry worldwide. The main objective of this study was to estimate herd-level costs incurred by expenditures and production losses associated with mastitis on Canadian dairy farms in 2015, based on producer reports. Previously, published mastitis economic frameworks were used to develop an economic model with the most important cost components. Components investigated were divided between clinical mastitis (CM), subclinical mastitis (SCM), and other costs components (i.Serviceshttps://denishaine.ca/services/services/
Thu, 19 Apr 2018 00:00:00 +0000denis.haine@gmail.comhttps://denishaine.ca/services/services/ Experienced professional working with public and private organisations to help improve human and animal health, for more than 10 years.
Epidemiology &amp; Biostatistics Statistical analysis Epidemiological analysis Qualitative and quantitative risk assessment Diagnostic tests evaluation Data visualisation Predictive modelling Mathematical and stochastic modelling, simulations Economic modelling Clinical and field trials (human and animal health) Systematic reviews Meta-analysis Study design Questionnaire design Sampling design Sample size and allocation Training in epidemiology and using R statistical software Workshop Learning materials Curriculum Vitaehttps://denishaine.ca/cv/denishaine_cv_en/
Tue, 17 Apr 2018 00:00:00 +0000denis.haine@gmail.comhttps://denishaine.ca/cv/denishaine_cv_en/Professional Experience Since 2010 Consultant in epidemiology and biostatistics
2017 - 2018 Post-doctoral researcher, Canadian Bovine Mastitis and Milk Quality Research Network, Faculté de médecine vétérinaire, Université de Montréal, QC, Canada
2010 - 2011 Research Associate and Scientific Assistant, Canadian Bovine Mastitis Research Network, Faculté de médecine vétérinaire, Université de Montréal, QC, Canada
2007 - 2010 Director of Biostatistics, JSS Medical Research, QC, Canada
2003 - 2006 Consultant - Epidemiologist, Épidémio-Qualité Inc.Early-lactation extended pirlimycin therapy against naturally acquired Staphylococcus aureus intramammary infections in heifers: A randomized controlled trialhttps://denishaine.ca/publication/pirly/
Tue, 16 Jan 2018 00:00:00 +0000denis.haine@gmail.comhttps://denishaine.ca/publication/pirly/The primary objective of the current study was to evaluate cure rate following an early-lactation extended intramammary pirlimycin treatment on heifers naturally infected by Staphylococcus aureus. The secondary objective was to assess Petrifilm Staph Express (3M Microbiology, St. Paul, MN) count plate characteristics when used in a protocol for early-lactation detection of infected quarters in heifers. Milk samples were collected from heifers (n = 946) in the first few days following calving (mean = 5 d).Diagnosing intramammary infection: Controlling misclassification bias in longitudinal udder health studieshttps://denishaine.ca/publication/bias_udder_health/
Mon, 25 Dec 2017 00:00:00 +0000denis.haine@gmail.comhttps://denishaine.ca/publication/bias_udder_health/Using imperfect tests may lead to biased estimates of disease frequency and of associations between risk factors and disease. For instance in longitudinal udder health studies, both quarters at risk and incident intramammary infections (IMI) can be wrongly identified, resulting in selection and misclassification bias, respectively. Diagnostic accuracy can possibly be improved by using duplicate or triplicate samples for identifying quarters at risk and, subsequently, incident IMI. The objectives of this study were to evaluate the relative impact of selection and misclassification biases resulting from IMI misclassification on measures of disease frequency (incidence) and of association with hypothetical exposures.episensr_shiny: episensr as a Shiny apphttps://denishaine.ca/software/episensr_shiny/
Fri, 17 Nov 2017 00:00:00 +0000denis.haine@gmail.comhttps://denishaine.ca/software/episensr_shiny/Based on my R package episensr, a Shiny app is available to easily assess the effect of biases on epidemiological results.
The app can be found at https://dhaine.shinyapps.io/episensr_shiny/.Popularity of statistical softwares in epidemiologyhttps://denishaine.ca/blog/popepi-rmd/
Wed, 15 Nov 2017 00:00:00 +0000denis.haine@gmail.comhttps://denishaine.ca/blog/popepi-rmd/Bob Muenchen has a series of articles on the Popularity of Data Science Software. He found that SPSS is the most used software, followed by R, SAS, Stata, GraphPad Prism, and MATLAB, by looking at scholarly articles in Google Scholar. He presents his methodology here. While he’s showing popularity (or market share) of several softwares for data science, statistical analysis, machine learning, artificial intelligence, predictive analytics, business analytics, and business intelligence, I was always wondering what the results would be like for my specific field, epidemiology.Episensr 0.9.2 now available on CRANhttps://denishaine.ca/blog/episensr-092-rmd/
Tue, 14 Nov 2017 00:00:00 +0000denis.haine@gmail.comhttps://denishaine.ca/blog/episensr-092-rmd/Bug fixes were brought to episensr R package, regarding the use of distributions and computations of odds and risk ratios in probsens.conf function for the probabilistic sensitivity analysis for unmeasured confounder. Improvement on the use of distributions was also brought to other probsens series of functions. Let’s run the example from Modern Epidemiology by Rothman, Greenland &amp; Lash, on page 365-366.
This example is taken from a paper by Greenland et al.Episensr as a Shiny app!https://denishaine.ca/blog/episensr_shiny/
Sun, 15 Oct 2017 00:00:00 +0000denis.haine@gmail.comhttps://denishaine.ca/blog/episensr_shiny/My R package episensr can now also be used through a new Shiny application, episensr_shiny, to more easily assess the effect of biases on epidemiological results.
Not all functions and options are available yet, only selection bias and misclassification of exposure or outcome can be specified. But direct consequences of modifying the bias parameters by moving the sliders can be checked on the 2-by-2 tables and measures of association.
This is therefore still in &ldquo;beta&rdquo; but more will come.Scientific collaboration patterns in cattle health research in Canadahttps://denishaine.ca/blog/dairyres-rmd/
Wed, 11 Oct 2017 00:00:00 +0000denis.haine@gmail.comhttps://denishaine.ca/blog/dairyres-rmd/I was curious to see if I could identify some patterns of collaboration and research topics in cow health research made in Canada. For this, I’m trying the R package bibliometrix. This package allows quantitative research in scientometrics and bibliometrics by providing different routines for importing bibliographic data from Scopus and ISI Web of Knowledge databases, and performing various bibliometric analyses. The Bibliometrix website provides a good tutorial that I will mainly follow, with the sole objective to satisfy my curiosity and have fun!Culling from the actors' perspectives—Decision-making criteria for culling in Québec dairy herds enrolled in a veterinary preventive medicine programhttps://denishaine.ca/publication/culling_q/
Mon, 09 Oct 2017 00:00:00 +0000denis.haine@gmail.comhttps://denishaine.ca/publication/culling_q/The series of events leading to the decision to cull a cow is complex, involving both individual-level and herd-level factors. While the decision is guided by financial returns, it is also influenced by social and psychological factors. Research studies on the motivational and behavioural aspects of farmers&rsquo; decision utility are sparse, and nonexistent regarding culling expectations and its decision process. Our goal was to identify shared criteria on culling decisions held by dairy producers and farm advisers, with the help of the Q-methodology.Culling from the herd's perspective—Exploring herd-level management factors and culling rates in Québec dairy herdshttps://denishaine.ca/publication/culling_mfa/
Fri, 22 Sep 2017 00:00:00 +0000denis.haine@gmail.comhttps://denishaine.ca/publication/culling_mfa/The relationship between cows&rsquo; health, reproductive performance or disorders and their longevity is well demonstrated in the literature. However these associations at the cow level might not hold true at the herd level, and herd-level variables can modify cow-level outcomes independently of the cows&rsquo; characteristics. The interaction between cow-level and herd-level variables is a relevant issue for understanding the culling of dairy cows. However it requires the appropriate group-level variables to assess any contextual effect.Marginal structural Cox model to estimate the causal effect of clinical mastitis on Québec dairy cow culling riskhttps://denishaine.ca/publication/culling_msm/
Wed, 20 Sep 2017 00:00:00 +0000denis.haine@gmail.comhttps://denishaine.ca/publication/culling_msm/Health disorders, such as milk fever, displaced abomasum, or retained placenta, as well as poor reproductive performance, are known risk factors for culling in dairy cows. Clinical mastitis (CM) is one of the most influential culling risk factors. However the culling decision could be based either on the disease status or on the current milk yield, milk production being a significant confounder when modelling dairy cow culling risk. But milk yield (and somatic cell count) are time-varying confounders, which are also affected by prior CM and therefore lie on the causal pathway between the exposure of interest, CM, and the outcome, culling.Contextual herd factors associated with cow culling risk in Québec dairy herds: A multilevel analysishttps://denishaine.ca/publication/culling_contextual/
Fri, 01 Sep 2017 00:00:00 +0000denis.haine@gmail.comhttps://denishaine.ca/publication/culling_contextual/Several health disorders, such as milk fever, displaced abomasum, and mastitis, as well as impaired reproductive performance, are known risk factors for the removal of affected cows from a dairy herd. While cow-level risk factors are well documented in the literature, herd-level associations have been less frequently investigated. The objective of this study was to investigate the effect of cow- and herd-level determinants on variations in culling risk in Québec dairy herds: whether herd influences a cow&rsquo;s culling risk.Episensr 0.9.0 now available on CRANhttps://denishaine.ca/blog/episensr-090-rmd/
Mon, 21 Aug 2017 00:00:00 +0000denis.haine@gmail.comhttps://denishaine.ca/blog/episensr-090-rmd/A small update for my episensr R package is now available on CRAN. The update focus on misclassification.
First, covariate misclassification is now available, via the function misclassification_cov. For example, the paper by Berry et al. looked if misclassification of the confounding variable in vitro fertilization (IVF), a confounder, resulted wrongly on an association between increase folic acid and having twins. IVF increases the risk of twins, and women undergoing IVF might be more likely to take folic acid supplements, i.Making the news!https://denishaine.ca/blog/making-the-news-md/
Thu, 29 Jun 2017 00:00:00 +0000denis.haine@gmail.comhttps://denishaine.ca/blog/making-the-news-md/We&rsquo;re making the news (Simon Dufour, Sébastien Buczinski, David Francoz, Nandini Dendukuri, and me) in the first newsletter of LCMATE, the mailing list for those interested in latent class models for the evaluation of diagnostic tests.
You can find the newsletter here.Moving!https://denishaine.ca/blog/first-one-md/
Thu, 29 Jun 2017 00:00:00 +0000denis.haine@gmail.comhttps://denishaine.ca/blog/first-one-md/Slowing moving my blog from Wordpress to here, using blogdown!episensr: Basic Sensitivity Analysis of Epidemiologic Resultshttps://denishaine.ca/software/episensr/
Tue, 13 Jun 2017 00:00:00 +0000denis.haine@gmail.comhttps://denishaine.ca/software/episensr/The R package episensr allows to do basic sensitivity analysis of epidemiological results as described in Applying Quantitative Bias Analysis to Epidemiological Data by Timothy L. Lash, Matthew P. Fox, and Aliza K. Fink (ISBN: 978-0-387-87960-4, bias.analysis).
Example We will use a case-control study by Stang et al. on the relation between mobile phone use and uveal melanoma. The observed odds ratio for the association between regular mobile phone use vs.misclass: Sampling Strategies to Control for Misclassification Biashttps://denishaine.ca/software/misclass/
Tue, 13 Jun 2017 00:00:00 +0000denis.haine@gmail.comhttps://denishaine.ca/software/misclass/R package to assess misclassification bias in hierarchical longitudinal studies and the effect of various sampling strategies to control for it. This package is part of the scientific paper &ldquo;Diagnosing intramammary infection: Controlling misclassification bias in longitudinal udder health studies&rdquo; (in press, Preventive Veterinary Medicine) and the 2017 SVEPM proceedings &ldquo;Sampling Strategies to Control Misclassification Bias in Longitudinal Udder Health Studies&rdquo; by Denis Haine, Ian Dohoo, Daniel Scholl, Henryk Stryhn, and Simon Dufour.Prediction of bulk tank somatic cell count violations based on monthly individual cow somatic cell count datahttps://denishaine.ca/publication/btscc/
Tue, 06 Jan 2015 00:00:00 +0000denis.haine@gmail.comhttps://denishaine.ca/publication/btscc/The regulatory limit in Canada for bulk tank somatic cell count (BTSCC) was recently lowered from 500,000 to 400,000 cells/mL. Herd indices based on changes in cow somatic cell count over 2 consecutive months (e.g., proportion of healthy or chronically infected cows, cows cured, and new intramammary infection rate) could be used as predictors for BTSCC violations. The objective of this study was to develop a predictive model for exceeding the limit of 400,000 cells/mL in the next month using these herd indices.Genotypic and phenotypic characterization of Staphylococcus aureus causing persistent and nonpersistent subclinical bovine intramammary infections during lactation or the dry periodhttps://denishaine.ca/publication/subclinical_saureus/
Wed, 24 Sep 2014 00:00:00 +0000denis.haine@gmail.comhttps://denishaine.ca/publication/subclinical_saureus/Staphylococcus aureus is a significant pathogen frequently causing persistent intramammary infections (IMI) in dairy cows. We compared some genotypic and phenotypic characteristics of 285 strains collected from quarter milk samples from cows with persistent and nonpersistent subclinical IMI across Canada. Variable number of tandem repeats typing was used to infer the persistence of the same S. aureus strain in 3 consecutive quarter milk samples collected at intervals of 3 wk during lactation or before and after dry-off.Zinc as an agent for the prevention of biofilm formation by pathogenic bacteriahttps://denishaine.ca/publication/zinc_biofilm/
Wed, 13 Mar 2013 00:00:00 +0000denis.haine@gmail.comhttps://denishaine.ca/publication/zinc_biofilm/AIMS: Biofilm formation is important for the persistence of bacteria in hostile environments. Bacteria in a biofilm are usually more resistant to antibiotics and disinfectants than planktonic bacteria. Our laboratory previously reported that low concentrations of zinc inhibit biofilm formation of Actinobacillus pleuropneumoniae. The aim of this study is to evaluate the effect of zinc on growth and biofilm formation of other bacterial swine pathogens. METHODS AND RESULTS: To determine the effect of zinc on biofilm formation, biofilms were grown with or without zinc in 96-well plates and stained with crystal violet.Characterization of the ability of coagulase-negative staphylococci isolated from the milk of Canadian farms to form biofilmshttps://denishaine.ca/publication/cns_biofilm/
Thu, 20 Sep 2012 00:00:00 +0000denis.haine@gmail.comhttps://denishaine.ca/publication/cns_biofilm/&ldquo;Mastitis is the most common and detrimental infection of the mammary gland in dairy cows and has a major economic impact on the production of milk and dairy products. Bacterial mastitis is caused by several pathogens, and the most frequently isolated bacterial species are coagulase-negative staphylocci (CNS). Although CNS are considered minor mastitis pathogens, the importance of CNS has increased over the years. However, the mechanism and factors involved in CNS intramammary infection are poorly studied and defined.Bayesian estimation of the diagnostic accuracy of a multiplex real-time PCR assay and bacteriological culture for 4 common bovine intramammary pathogenshttps://denishaine.ca/publication/multiplex_pcr/
Mon, 09 Jul 2012 00:00:00 +0000denis.haine@gmail.comhttps://denishaine.ca/publication/multiplex_pcr/Bacteriological culture (BC) is the traditional method for intramammary infection diagnosis but lacks sensitivity and is time consuming. Multiplex real-time PCR (mr-PCR) enables testing the presence of several bacteria and reduces diagnosis time. Our objective was to estimate bacterial species-specific sensitivity (Se) and specificity of both BC and mr-PCR tests for detecting bacteria in milk samples from clinical mastitis cases and from apparently normal quarters, using a Bayesian latent class model.Examining the effect of intramammary infections with minor mastitis pathogens on the acquisition of new intramammary infections with major mastitis pathogens - A systematic review and meta-analysishttps://denishaine.ca/publication/meta_imi/
Wed, 27 Jun 2012 00:00:00 +0000denis.haine@gmail.comhttps://denishaine.ca/publication/meta_imi/Major mastitis pathogens such as Staphylococcus aureus, Streptococcus agalactiae, Streptococcus uberis, Streptococcus dysgalactiae, and the coliforms are usually considered more virulent and damaging to the udder than minor mastitis pathogens such as Corynebacterium bovis and coagulase-negative staphylococci (CNS). The current literature contains several studies detailing analyses with conflicting results as to whether intramammary infection (IMI) with the minor pathogens decreases, increases, or has no effect on the risk of a quarter acquiring a new intramammary infection (NIMI) with a major pathogen.Identification of coagulase-negative Staphylococcus species by gas chromatographyhttps://denishaine.ca/publication/cns_chromato/
Sun, 01 Jan 2012 00:00:00 +0000denis.haine@gmail.comhttps://denishaine.ca/publication/cns_chromato/Researching the impact and epidemiology of coagulase-negative Staphylococcus species (CNS) causing intramammary infections (IMI) require their identification at the species level. Gene sequencing is the gold standard but faster and less expensive methods could be useful. The Sherlock Microbial Identification System is an automated gas chromatographic (MIS-GC) system able to speciate CNS isolates in human clinical medicine by identifying the unique cellular fatty acid patterns in bacteria cell walls. Our objective was to validate the MIS-GC method for speciating CNS responsible for IMI in dairy cows.Tolerability and effectiveness of preservative-free dorzolamide–timolol (preservative-free COSOPT®) in patients with open-angle glaucoma or ocular hypertensionhttps://denishaine.ca/publication/cosopt/
Sat, 12 Jun 2010 00:00:00 +0000denis.haine@gmail.comhttps://denishaine.ca/publication/cosopt/Purpose: To assess the effect of preservative-free dorzolamidetimolol on nonvisual symptoms and intraocular pressure (IOP) in newly diagnosed and untreated patients with open-angle glaucoma or ocular hypertension. Methods: This was a prospective, 8-week, open-label, Canadian multicenter study. All patients were treated with preservative-free dorzolamidetimolol formulation. The primary outcome was the change in the nonvisual symptom score of the Glaucoma Symptom Scale (GSS-SYMP-6) from baseline to 8 weeks. Secondary effectiveness outcome measures were absolute and percent changes in IOP from baseline to 4 and 8 weeks.Tramiprosate in mild-to-moderate Alzheimer's disease - a randomized, double-blind, placebo-controlled, multi-centre study (the Alphase Study)https://denishaine.ca/publication/tramiprosate/
Fri, 28 May 2010 00:00:00 +0000denis.haine@gmail.comhttps://denishaine.ca/publication/tramiprosate/Introduction: The aim of the study was to assess the clinical efficacy, safety, and disease-modification effects of tramiprosate (homotaurine, ALZHEMED&trade;) in mild-to-moderate Alzheimer&rsquo;s disease (AD). Material and methods: Double-blind, placebo-controlled, randomized trial in 67 clinical centres across North America. Patients aged &gt;= 50 years, with mild-to-moderate AD (Mini-Mental State Examination score between 16 and 26) and on stable doses of cholinesterase inhibitors, alone or with memantine. Intervention: 78-week treatment with placebo, tramiprosate 100 mg or tramiprosate 150 mg BID.Domain-specific cognitive effects of tramiprosate in patients with mild to moderate Alzheimer's disease: ADAS-cog subscale results from the Alphase Studyhttps://denishaine.ca/publication/adas/
Wed, 15 Jul 2009 00:00:00 +0000denis.haine@gmail.comhttps://denishaine.ca/publication/adas/OBJECTIVES: Tramiprosate (homotaurine, ALZHEMED&trade;) was recently investigated for its efficacy, safety and disease-modification effects in a Phase III clinical study in mild to moderate Alzheimer&rsquo;s disease (AD) patients (the Alphase study). The primary cognitive endpoint measure of that study was the Alzheimer&rsquo;s Disease Assessment Scale-cognitive subscale (ADAS-cog). To characterize potential cognitive benefits of tramiprosate, the present study describes exploratory analyses performed on scores obtained from the specific ADAS-cog subscales in order to determine whether specific domains of cognition may be differentially affected by tramiprosate, which would not have been evident from the measure&rsquo;s total score.Montelukast as add-on therapy to inhaled corticosteroids in the management of asthma (the SAS trial)https://denishaine.ca/publication/montelukast/
Fri, 01 May 2009 00:00:00 +0000denis.haine@gmail.comhttps://denishaine.ca/publication/montelukast/AIM: To evaluate the effectiveness of montelukast as add-on therapy for asthmatic patients who remain uncontrolled with low, moderate or high doses of inhaled corticosteroid monotherapy. DESIGN: An eight-week, multicentre, open-label, observational study. RESULTS: Of 320 patients enrolled, 288 (90.0%) completed the study. Of patients who had uncontrolled asthma symptoms (Canadian Asthma Consensus Guidelines Update, 2003) but were controlled according to the Asthma Control Questionnaire (ACQ score of less than 1.Effect of tramiprosate in patients with mild-to-moderate Alzheimer's disease: Exploratory analyses of the MRI sub-group of the Alphase studyhttps://denishaine.ca/publication/tramiprosate_mri/
Wed, 25 Mar 2009 00:00:00 +0000denis.haine@gmail.comhttps://denishaine.ca/publication/tramiprosate_mri/Objectives: The efficacy, safety and disease-modification of tramiprosate (homotaurine) were investigated in a recently completed large-scale Phase III clinical study in patients with mild to moderate Alzheimer&rsquo;s disease (AD), the Alphase study. Disease-modification was assessed using longitudinal volumetric MRI (vMRI) measurements of the hippocampus in a subgroup of patients. The present study describes the vMRI, cognitive and clinical results obtained in this subgroup. Design: Multi-center, double-blind, randomized, placebo-controlled study in a subset of the 1052 patients of the Alphase study.Lessons learned in the use of volumetric MRI in therapeutic trials in Alzheimer's disease: the ALZHEMED (Tramiprosate) experiencehttps://denishaine.ca/publication/ad_lessons/
Mon, 12 Jan 2009 00:00:00 +0000denis.haine@gmail.comhttps://denishaine.ca/publication/ad_lessons/In Journal of Nutrition, Health, and AgingHerd-level seroprevalence and risk-mapping of bovine hypodermosis in Belgian cattle herdshttps://denishaine.ca/publication/hypoderma/
Tue, 08 Jun 2004 00:00:00 +0000denis.haine@gmail.comhttps://denishaine.ca/publication/hypoderma/Our objective was to determine the seroprevalence of Hypoderma spp. and to develop a spatial model describing the risk surface of warble-fly infection in Belgian cattle herds (adjusting for herd size, herd type, local temperature, rainfall, relative air humidity and land-cover). This survey was carried out in 390 selected herds of all types (dairy, mixed and beef) from December 1997 to March 1998, which were included in a national infectious bovine rhinotracheitis and paratuberculosis (Johne&rsquo;s-disease) survey.What can I do for you?https://denishaine.ca/contact/contact/
Mon, 01 Jan 0001 00:00:00 +0000denis.haine@gmail.comhttps://denishaine.ca/contact/contact/I can help you make the most out of your data, to be collected or already in hand, through specific analyses, training or applications development.
For further information, please contact me!
denis.haine@gmail.com
+1-514-572-7174