The Journal of the American Veterinary Medical Association has published a report in its April 1, 2008 issue, Vol. 232, No. 7, entitled: Postmarketing Surveillance of Rabies Vaccines for Dogs to Evaluate Safety and Efficacy."

Despite the extreme under-reporting of vaccinal adverse reactions, this report states on the second page that between April 1, 2004 and March 31, 2007, the Center for Veterinary Biologics, "nearly 10,000 adverse event reports (all animal species) were received by manufacturers of rabies vaccines..........Approximately 65% of the manufacturer's reports involved dogs."

The report further states on the second page that: "Rabies vaccines are the most common group of biological products identified in adverse event reports received by the CVB," and they give the following description of the adverse reaction followed by the % of dogs affected: Vomiting-28.1%, Facial Swelling-26.3%, Injection Site Swelling or Lump-19.4%, Lethargy-12%, Urticaria-10.1%, Circulatory shock-8.3%, Injection site pain-7.4%, Pruritus-7.4%, Injection site alopecia or hair loss-6.9%, Death-5.5%, Lack of Consciousness-5.5, Diarrhea-4.6%, Hypersensitivity (not specified)-4.6%, Fever-4.1%, Anaphylaxis-2.8%, Ataxia-2.8%, Lameness-2.8%, General signs of pain-2.3%, Hyperactivity-2.3%, Injection site scab or crust-2.3%, Muscle tremor-2.3%, Tachycardia-2.3%, and Thrombocytopenia-2.3%.

Veterinarians are not required by law to report adverse reactions to vaccines, to which the World Small Animal Veterinary Association stated in their 2007 Vaccine Guidelines that there is: "gross under-reporting of vaccine-associated adverse events which impedes knowledge of the ongoing safety of these products," and in an article entitled, A New Approach to Reporting Medication and Device Adverse Effects and Product Problems, (JAMA - June 2, 1993. Vol.269, No.21. p.2785) Dr. David Kessler, former head of the Food & Drug Administration, reported that "only about 1% of serious events are reported to the FDA."

In light of the 10,000 adverse reactions to the rabies vaccine in the JAVMA report, 65% of which were in dogs, the estimated 1% reporting of "serious" events by the former head of the FDA means that the actual number of dogs that had adverse reactions to the vaccine would be more like 650,000!!!!!

No one is suggesting that people should not vaccinate their dogs against rabies. The point here is that dog owners should be aware that there are potential adverse reactions associated with the rabies vaccine and states/communities should not require that dogs be vaccinated any more often than is necessary to maintain adequate immunity to rabies.

The following quote is from the Center for Disease Control's MMWR Recommendations and Reports March 22, 1991/40(RR03);1-19 Rabies Prevention-- United States, 1991 Recommendations of the Immunization Practices Advisory Committee http://www.cdc.gov/mmwr/preview/mmwrhtml/00041987.htm

"A fully vaccinated dog or cat is unlikely to become infected with rabies, although rare cases have been reported (48). In a nationwide study of rabies among dogs and cats in 1988, only one dog and two cats that were vaccinated contracted rabies (49). All three of these animals had received only single doses of vaccine; no documented vaccine failures occurred among dogs or cats that had received two vaccinations. " .

Personally, I believe the adjuvants and preservatives in the rabies vaccine are a problem. Rabies, Leptospira, Lyme, are killed, adjuvanted vaccines. Adjuvants are vaccine components (such as aluminum hydroxide, aluminum phosphate) used to enhance the immunological response.
"The World Health Organization (WHO) in 1999 classified veterinary vaccine adjuvants as Class III/IV carcinogens with Class IV being the highest risk," IARC Monographs on the Evaluation of Carcinogenic Risks to Humans: Volume 74, World Health Organization, International Agency for Research on Cancer, Feb. 23-Mar. 2, 1999, p. 24, 305, 310.)

According to the 2003 American Animal Hospital Association's Canine Vaccine Guidelines http://www.leerburg.com/special_report.htm (Page 16), "...killed vaccines are much more likely to cause hypersensitivity reactions (e.g., immune-mediated disease)." Could this be due to the combination of mercury (thimersol) and aluminum additives in the same vaccine?

Mercury (Thimersol) is commonly found as a preservative in killed, adjuvanted veterinary vaccines. The combination of the mercury (thimersol) and adjuvant components (aluminum hydroxide, aluminum phosphate) in the same vaccine are of considerable concern because of the reactive properties of aluminum, especially when in contact with mercury (thimsersol).

Please see the information below, as well as a Congressional petition to remove aluminum additives in human vaccines. Remember, mercury (thimersol) is still used in veterinary vaccines along with aluminium.

Aluminum amalgam http://en.wikipedia.org/wiki/Mercury-aluminum_amalgam"Due to the reactivity of aluminium amalgam, restrictions are placed on the use and handling of mercury in proximity with aluminium. In particular, mercury is not allowed aboard aircraft under most circumstances because of the risk of it forming amalgam with exposed aluminium parts in the aircraft. In the Second World War, mercury was used to sabotage aircraft."

Petition to Congress "Removal of Aluminum Additive in Vaccines Resolution and Petition" www.petitiononline.com/NoMadVac/petition.html"The combination of mercury plus aluminum is far worse than the sum of the two toxicities added together. The synergistic toxicity could be increased to unknown levels."_________________Kris L. Christine
Founder, Co-Trustee
THE RABIES CHALLENGE FUND
www.RabiesChallengeFund.org

There are adverse reactions to ALL medicines/vaccination. It is just the chance you take.

It matters not the number of times a dog/cat has to be vaccinated. If the animal has developed an allergic reaction to the vaccine, then the owner needs to find an alternative vaccine/treatment......or risk being in violation of the local animal health codes.

To not vaccinated because there is a miniscule chance of an allergic reaction is irresponsible. These are dogs/cats....animals.

"It would be wonderful to be able to offer a Titer to see if an animal is in fact immune to the rabies virus, however at this time there is not enough information for Titer testing to be an accurate determinant of immunity to the virus," Rule said.

Vets agree more research needs to be done to see if dogs are over-vaccinated against rabies.

Recommendations for maintaining adequate pre-exposure immunization status: A routine booster every two years is NOT recommended since the newer cell culture vaccines often confer adequate antibody levels for 5 to 8 years and risk of adverse reactions is increased by frequent boosters. The standard pre-exposure recommendation for veterinarians practicing in an area with enzootic rabies is serologic testing every two years with booster vaccination when the antibody titer falls below the acceptable level, i.e. 1:5 by RFFIT._________________Kris L. Christine
Founder, Co-Trustee
THE RABIES CHALLENGE FUND
www.RabiesChallengeFund.org

Adverse reactions have also become a major concern in small animal medicine. .... These fall into two general categories. The first is immediate hypersensitivity. This may be a local or systemic response, and is due to pre-existing antibody to the agent. This is the classic "allergic reaction" to the vaccine and can be life-threatening. The second is a delayed response, requiring days of longer to develop. The vaccine, seen as foreign, elicits a significant inflammatory response and is especially true for adjuvanted vaccines. This response can manifest as a granuloma, or more seriously, a fibrosarcoma .

Further, she reports that The likelihood of adverse reactions in dogs has been found to correlate with the size of the dog and the number of inoculations given, with higher risk associated with small size and multiple inoculations.

Rabies Prevention -- United States, 1991 Recommendations of the Immunization Practices Advisory Committee (ACIP), Center for Disease Control's Morbidity and Mortality Weekly March 22, 1991 / 40(RR03);1-19 http://www.cdc.gov/mmwr/preview/mmwrhtml/00041987.htm"A fully vaccinated dog or cat is unlikely to become infected with rabies, although rare cases have been reported (48). In a nationwide study of rabies among dogs and cats in 1988, only one dog and two cats that were vaccinated contracted rabies (49). All three of these animals had received only single doses of vaccine; no documented vaccine failures occurred among dogs or cats that had received two vaccinations. "_________________Kris L. Christine
Founder, Co-Trustee
THE RABIES CHALLENGE FUND
www.RabiesChallengeFund.org

Judy Schor's agility champion, Peaches, suffered a significant adverse reaction to a rabies booster. Judy has posted photos of Peaches and a letter from the vaccine manufacturer, Fort Dodge, offering a settlement to pay for medical treatment if they not disclose information about the claim. You can read the letter and see photos of Peaches at this link: http://www.facebook.com/album.php?aid=2042916&id=1447415540&ref=mf ._________________Kris L. Christine
Founder, Co-Trustee
THE RABIES CHALLENGE FUND
www.RabiesChallengeFund.org