In an exclusive video interview, the star dishes to PEOPLE about all the important moments in her life this past year.

“I guess the most joyful moment was the first day I felt the show was where I wanted it to be,” Handler, 41, says about her Netflix show Chelsea. “That just kind of set the tone for the rest of the year.”

On another high note, Handler reveals when she felt most beautiful: “The other night I went to an event and I was wearing this Valentino dress. It was something I had never worn before that was beautiful,” she recalls. “I was like, ‘Oh my god, I look beautiful!’ And I never, ever think that.”

She adds, “And then the next day I looked like s— — but, you know, things happen.”

Although the currently single Handler says she doesn’t feel beautiful often, that doesn’t mean she isn’t confident or think that’s the most important quality. “I don’t feel beautiful a lot but I feel sexy a lot,” she clarifies. “I think lots of things are sexy and I think confidence is sexy and I’ve never been short on that.”

The star also offers up her most frustrating moment of the year was when she got sick and couldn’t work — proof that the comedian is a real professional. “When I get sick I get so frustrated. I got sick this year and that’s the most frustrated I get. I hate when I can’t work. If I’m holding other people up or people feel sorry for me, I hate that feeling. It, like, makes me cry,” she admits.

On the flip side, Handler shares that her “most hilarious moment was the other night at my house when I had a little mushroom pot. I was laughing so hard I peed a little bit,” the comedian reveals while adding that the thought of changing her underwear afterwards was too complicated for her at the time. “But that’s what’s fun about being an adult and having no responsibilities for children.”

For more from Chelsea Handler, pick up this week’s issue of PEOPLE, on newsstands Friday

Jana Cruder

The talk show host also reveals that her most surprising moment of the year was when she visited her newly purchased house in Spain and realized that it was even more beautiful than she remembered — a fact that she sarcastically says makes her “so relatable.” “I bought a house in Spain and I showed up after all the construction had been done and it was more beautiful than I had even imagined. I didn’t even know I had picked out all those things,” Handler says.

And the avid supporter of former presidential nominee Hillary Clinton also reminisces about getting to honor Clinton at a Glamour event. “I’m always inspired by women like that who take their own personal time. There’s so much going on in the world and it’s so nice to see people that care that much.”

Chelsea premieres new episodes every Wednesday, Thursday and Friday on Netflix.