Mistresses: 22 Possible Subs for Alyssa Milano

Heather Locklear

Rebecca Mader

Eva Longoria

Sibel Kekilli

Charisma Carpenter

Jasika Nicole

Malin Akerman

Courteney Cox

Leighton Meester

Jamie-Lynn Sigler

Sarah Michelle Gellar

Naya Rivera

Tiffani Thiessen

Kim Cattrall

Christina Aguilera

Megan Hilty

Azita Ghanizada

Hettienne Park

Golden Brooks

AnnaLynne McCord

Michelle Money

Not technically an actress, true, but the Bachelor franchise vet has convincingly feigned interest in everyone from Brad Womack to oafish Cody (on Bachelor in Paradise). What better way to forge Monday night ABC synergy?

Penelope Ann Miller

Yes, her boozy, unhinged, murderous Mistresses character brutally tormented and threatened Yunjin Kim’s Karen, but did we mention she’s boozy, unhinged and murderous? (Great attributes in a primetime soap!) Plus, she’s prone to lines like, “Did you see [dead husband] Tom’s face when you were screwing my son?” Sign her up!