Manny Pacquiao's promoter, Bob Arum, expects the Filipino to fight Juan Manuel Marquez for a fifth - and possibly final - time in 2013, but concedes Pacquiao is unlikely to ever face Floyd Mayweather Jr.

Pacquiao was knocked out by Marquez in the fourth meeting between the two men at the start of December, a bout that finally brought a decisive conclusion to a series of meetings that had seen Pacquiao edge narrow, and hugely controversial, points victories.

But the overhand right from Marquez that floored Pacquiao might not be the last punch thrown between the pair, with Arum admitting that a fifth contest is likely for 2013 - after the fourth meeting proved so popular with fans.

"We're gonna, I think, do another fight with Juan Manuel Marquez," Arum said, in an interview with TMZ. "That was a great fight.

"He [Pacquiao] ran into a really good right hand, and we'll see what happens next time."

The defeat for Pacquiao - his second in succession, after a hugely-disputed points loss to Timothy Bradley earlier in the year - further diminished the anticipation for a blockbuster meeting with Floyd Mayweather, while also giving the American the upper hand in negotiations that have previously proven unable to conclude.

And Arum conceded that a meeting between the pair now appears unlikely.

When asked if Pacquiao will face Mayweather before he retires, Arum added: "Probably not, but life goes on."