The Colorectal Cancer Family Registry (Colon CFR) Cohort is an international consortium of six institutes in North America and Australia formed as a resource to support studies on the etiology, prevention, and clinical management of colorectal cancer.

The resource comprises data and biospecimens from over 40,000 participants from 14,000 families that have been recruited from 1998 to 2011.

Standardized protocols have been used to collect information regarding family cancer history and colorectal cancer risk factors, and biospecimens have been obtained to assess microsatellite instability (MSI) status, expression of mismatch repair proteins, and other molecular and genetic processes.