MMP-3 produced in blood vessel endothelial cells after spinal cord injury serves as an endogenous molecule for microglial activation followed by p38MAPK (show MAPK14 ELISA Kits) activation and proNGF production

genetic inactivation of MMP-3 has profound effects on the structural integrity and plasticity response of the visual cortex of adult mice

Our findings suggest that increased numbers of CD11c (show ITGAX ELISA Kits)(+) macrophages and elevated levels of TNF-alpha (show TNF ELISA Kits) and MMP-3 in AT and ST may explain the relationship between hyperlipidaemia and OA.

These results demonstrated the role of MMP-3 in blood-spinal cord disruption after spinal cord injury for the first time

Antigen Summary

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. The enzyme is thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.