From Garristown, County Dublin, Lisa had already ridden a winner in Britain when she landed her first Irish success in the Thalgo Ladies Derby on the Pat Flynn-trained Mon Champion at the Curragh in July, 2010. Closely associated with the Gordon Elliott stable for many years, the County Meath trainer provided Lisa with her biggest success when Wrath Of Titans won the Guinness Kerry National Handicap Chase at Listowel on September 14th, 2016. It was her first winner over fences and her 15th success under rules. At the time, she has six point-to-point winners to her name. A daughter of trainer and former jockey Tommy O'Neill, Lisa became the second female rider to win the Guinness Kerry National. Katie Walsh won the race on the James Nash-trained Your Busy in 2014.

Lisa enjoyed a winner on the biggest stage of them all when landing the JT McNamara National Hunt Chase at the Cheltenham Festival on the Gordon Elliott-trained Tiger Roll on March 14th, 2017 and remarkably added a second Guinness Kerry National when successful on Potters Point, another trained by Gordon Elliott, at Listowel in September, 2018. With 20 winners, Lisa was crowned leading lady rider for the 2017/18 season on the final day of the Punchestown festival on April 28, 2018.

She rode out her claim with a double at Laytown in September, 2018 where she partnered two winners for British trainer Jamie Osborne and the Melbourne 10 Racing syndicate, Waqaas and Florencio.