It seems there is growing evidence to support that the concurrent use of PPIs and Plavix can put patients at increased risk for a recurrent cardiac event. Most trials with omeprazole show a decrease in clopidogrel effectiveness; however, there seems to be some limited evidence that pantoprazole may not be quite as bad (but nothing too convincing!).

What are your thoughts? There may be a clear role for the hospital pharmacist. Is there a role for the community pharmacist to have an impact here??