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Paget's Disease of the Breast

National Organization for Rare Disorders, Inc.

ImportantIt is possible that the main title of the report Paget's Disease of the Breast is not the name you expected.

Disorder Subdivisions

None

General Discussion

Summary

Paget's disease of the breast is a rare form of breast cancer that almost exclusively occurs in women. However, rare cases have been reported in men. Paget's disease of the breast is characterized by inflammatory, "eczema-like" changes of the nipple that may extend to involve the areola, which is the circular, darkened (pigmented) region of skin surrounding the nipple. Initial findings often include itching (pruritus), scaling, and crusting of and/or discharge from the nipple. In individuals with Paget's disease of the breast, distinctive tumor cells (known as Paget cells) are present within the outermost layer of skin (epidermis) of the nipple, when viewed under a microscope. Most women with this disorder have an underlying cancer (malignancy) affecting the milk ducts (ductal carcinoma). The milk ducts are the channels that carry milk secreted by lobes of the breast to the nipple. The exact cause of Paget's disease of the breast is not fully understood.

Introduction

Paget's disease of the breast was originally reported in 1874 by Sir James Paget, an English surgeon, who also described an unrelated skeletal condition known as Paget's disease of the bone. It is essential to note that these disorders are distinct entities that are medically unrelated.

Supporting Organizations

American Cancer Society, Inc.

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Tel: (404)320-3333

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Breast Cancer Society of Canada

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Canada

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Email: bcsc@bcsc.ca

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Canadian Breast Cancer Network

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Genetic and Rare Diseases (GARD) Information Center

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National Cancer Institute

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Website: http://www.cancer.gov/cancertopics/pdq/cancerdatabase

National Women's Health Network

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Fax: (202)682-2648

Email: healthquestions@nwhn.org

Website: https://nwhn.org/

OncoLink: The University of Pennsylvania Cancer Center Resource

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2 Donner

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USA

Tel: (215)349-8895

Fax: (215)349-5445

Email: hampshire@uphs.upenn.edu

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Rare Cancer Alliance

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USA

Website: http://www.rare-cancer.org

Rose Kushner 's Women's Breast Cancer Advisory Center

P.O. Box 757

Malaga Cove, CA 90274

Email: lkkushner@yahoo.com

Website: http://www.rkbcac.org/

SHARE - Self-Help For Women With Breast or Ovarian Cancer

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New York, NY 10036

Tel: (212)719-0364

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Tel: (866)891-2392

Email: info@sharecancersupport.org

Website: http://www.sharecancersupport.org/

Skin Cancer Foundation

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Tel: (212)725-5176

Fax: (212)725-5751

Tel: (800)754-6490

Email: info@skincancer.org

Website: http://www.skincancer.org

For a Complete Report

This is an abstract of a report from the National Organization for Rare Disorders (NORD). For a full-text version of this report, go to www.rarediseases.org and click on Rare Disease Database under "Rare Disease Information".

The information provided in this report is not intended for diagnostic purposes. It is provided for informational purposes only.

It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report.

This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.

Last Updated: 3/27/2012Copyright 2012 National Organization for Rare Disorders, Inc.

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