The chief river of the United States, rising in the lake region of northern Minnesota and flowing about 3,781 km (2,350 mi) generally southward to enter the Gulf of Mexico through a huge delta in southeast Louisiana. Probably discovered by Hernando de Soto in 1541, it was explored by Jacques Marquette and Louis Jolliet in 1673. La Salle claimed the entire region for France after he descended to the river's mouth in 1682.

The longest river in the United States. It has historically been a major transportation artery for goods and people. The name is Algonquin for "big river."

The largest river in North America, which runs from Northern Minnesota to the Gulf of Mexico.

or, for the pervs, the area between the breasts on a woman

1) I went rafting on the Mississippi River with my mom... ir rocked!

2) on their first date, he begged to lick her Mississippi River... but she refused (what a gaywad, that guy was)