Curbing Cellulitis Misdiagnosis

By staff

US Pharm. 2018;43(6):20-21.

Cellulitis—a bacterial infection of the skin—is a common medical condition, yet there is no diagnostic tool for it currently available. The only way to diagnose cellulitis is based on the appearance of the affected area and the patient’s reported symptoms. Many other medical conditions cause skin inflammation that mimics the appearance of cellulitis (known as pseudocellulitis) and are commonly misdiagnosed. A new study by researchers from Brigham and Women’s Hospital (BWH) demonstrates that early consultation by a dermatologist for patients with presumed cellulitis was a cost-effective intervention to prevent misdiagnoses and improve health-related outcomes. Their results were published in JAMA Dermatology.

“This is a big win-win for both the patients and for the hospitals,” said corresponding author Arash Mostaghimi, MD, MPA, MPH, director of inpatient dermatology. “Our findings show that early intervention by dermatologists for patients with presumptive cellulitis not only improves outcomes for the patients, but saves the hospitals on costs associated with unnecessary hospitalization and opens up beds in the emergency department.”

Previous work by Dr. Mostaghimi and his colleagues evaluated a series of patients in BWH’s emergency department with presumptive diagnoses of cellulitis and determined that a third of these patients had pseudocellulitis. Alarmed by this statistic, the dermatology consult team partnered with the inpatient group and the ED to provide dermatology consultation for 165 patients in the ED observation unit who were about to be admitted with presumptive diagnosis of cellulitis. A third of these patients were diagnosed with pseudocellulitis by dermatology consultation.

The dermatologists recommended the discontinuation of antibiotics in 82.4% of these patients and discharge from planned observation or inpatient admissions in half of the patients. None of the patients diagnosed with pseudocellulitis showed worsening of their condition after discharge.

Extrapolating from their findings, the researchers estimate that dermatology consultation for presumed cellulitis could nationally prevent between 97,000 and 256,000 hospitalization days and 34,000 and 91,000 cases of unnecessary antibiotic exposure. It could also result in net cost savings of $80 million to $210 million annually.