She is best known for appearing on the E! reality TV show Keeping Up with the Kardashians that she shares with her family members. She has appeared as herself on a number of television shows and award ceremonies, and in 2012 acted in an episode of Hawaii Five-0. With her sister, Kylie, she designs a clothing line called "Kendall & Kylie." Jenner is also a runway model and appears at public events.

She is best known for starring in Alondra (1995), Mujeres Engañadas (1999), Primer Amor (2000), Clase 406(2003), Rebelde (2004) and Dos Hogares (2011).She was a member of RBD, who were nominated twice for a Latin Grammy and sold over 20 million records. Before RBD, Anahí released four albums. The success of them was more limited, none of them officially charted. In 2009 she released the album Mi Delirio. The album had a moderate success selling 1.000.000 copies worldwide. She has sold 5 million albums as a solo artist.