A Multicenter, Double-Blind, Randomized, Placebo Controlled Comparison of the Effects on Sexual Functioning of Extended-Release Bupropion Hydrochloride (300-450mg) and Escitalopram (10-20mg) in Outpatients With Moderate to Severe Major Depression Over an Eight-Week Treatment Period

Primary diagnosis of Major Depressive Disorder (MDD) with current duration lasting 12 weeks but no greater than 2 years.

Subjects must engage in sexual activity that leads to orgasm at least once every two weeks.

Subject must have normal orgasmic function and be willing to discuss with investigator.

Exclusion Criteria:

Subjects that have arousal or orgasm dysfunction.

Has previously failed to respond to two adequate trials of antidepressants in past 2 years.

Subject has other unstable medical disorders.

Subject has a positive urine test for illicit drug use at screening.

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Please refer to this study by its ClinicalTrials.gov identifier: NCT00051259