22. Unlike her character Lexie Grey, who graduated from Harvard Medical School, Chyler Leigh dropped out of high school.

23. Jessica Capshaw auditioned for three roles on the show: first, Derek’s love interest Nurse Rose (Lauren Stamile), then Meredith’s crazy friend Sadie (Melissa George), and finally, she won the part of Arizona Robbins.

24. Arizona was originally just going to have a three-episode arc.

25. Bailey’s infamous vagina euphemism “vajayjay” was actually coined by an assistant on set. When Rhimes heard it, she wrote it into the script.

26. Brooke Smith, who played Dr. Erica Hahn (a love interest for Sara Ramirez’s Dr. Callie Torres), was let go from the show. She was told the writers could no longer “write for her character.”

27. In order to make sure that the check Denny (Jeffrey Dean Morgan) left Izzie was readable after weeks of wear-and-tear — and food spills — Grey’s propmaster Angela Whiting suggested just increasing the dollar amount.

28. When Derek writes his and Meredith’s wedding vows on a Post-it note, Dempsey was actually writing down the things they were saying in that moment.

29. Pompeo got pregnant while filming Season 6, but instead of making Meredith pregnant as well, the writers had the character give part of her liver to her estranged father, Thatcher (Jeff Perry), so that Pompeo could be confined to bed rest to hide her pregnant belly under sheets.