Alternatively, .NET Framework 4.5 can be used on managed computers running Windows 8 / Server 2012 or later

ControlUp requires RPC access for remote agent installation and a single configurable incoming TCP port open (40705 by default) for agent communication. In case your managed computers are inaccessible using RPC, you can deploy the ControlUp agent using an MSI package. For more details, see “Add Managed Computers”.