CCL20

CCL20

A gene on chromosome 2q33-q37 that encodes a chemotactic factor that attracts lymphocytes and neutrophils, but not monocytes. CCL20 inhibits proliferation of myeloid stem cells in colony formation assays, and may be involved in proliferation and activity of mucosal lymphoid tissues (e.g., BALT, MALT, SALT) by attracting lymphocytes and dendritic cells towards epithelial cells.

In vitro stimulation of Th17 or Tc17 cells in the presence of Lycera's RORgamma agonists increased the expression of costimulatory molecules and production of immune-enhancing cytokines, such as IL-17A, IL-17F, GM-CSF and CCL20, maintained IFNgamma production, and decreased expression of coinhibitory molecules, including PD-1, and the development of regulatory immune cells.

The study, performed in mouse models for asthma research, showed that the synthetic sulfate monosaccharide blocks the interaction between chemokine CCL20-a T-cell signaling protein and heparin sulfate, a molecule that protects and immobilizes CCL20 on epithelial cells in the lung.

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