In 2001, she began garnering attention from popular fashion magazines such as Vogue.[1] By May 2002, Ronson had opened her flagship store on Elizabeth Street in New York.[1] The Charlotte Ronson brand is partnered with Japanese apparel company, The Wall.

Ronson was born the daughter of writer and socialite Ann Dexter-Jones and real estate mogul Laurence Ronson.[4] She has said that her mother was strict when she was growing up and would not let her attend concerts.[5]

She has two siblings, twin sister Samantha Ronson, who is a DJ, and older brother Mark Ronson, who is a music producer, singer/songwriter, and DJ as well.[9] Ann Dexter-Jones and Laurence Ronson divorced. Ronson's mother remarried, to Mick Jones of Foreigner, and the family relocated to New York. Ronson has five half-siblings by her parents' remarriages.