Other events potentially associated with drug hypersensitivity, such as hypotension, urticaria, and dyspnea, each occurred in less than 0.9 percent of patients treated with ORENCIA and generally occurred within 24 hours of infusion.

In a retrospective study by Rabkin and associates, the most frequently occurring adverse effects included hypertensive reactions (some of these were due to inadvertent consumption of foods containing tyramine or concurrent use of catecholamine-containing drugs), orthostatic hypotension, hypomania, weight gain and sexual dysfunction. 2 In most cases adverse effects were controlled with dosage adjustments.