This is an Open Access article distributed under the terms of the Creative Commons Attribution License (
http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background

Mental disorders are classified by two major nosological systems, the ICD-10 and the DSM-IV-TR, consisting of different diagnostic criteria. The present study investigated the
diagnostic concordance between the two systems for anxiety disorders in childhood
and adolescence, in particular for separation anxiety disorder (SAD), specific phobia,
social phobia, and generalized anxiety disorder (GAD).

Methods

A structured clinical interview, the Kinder-DIPS, was administered to 210 children
and 258 parents. The percentage of agreement, kappa, and Yule’s Y coefficients were calculated for all diagnoses. Specific criteria causing discrepancies
between the two classification systems were identified.

Results

DSM-IV-TR consistently classified more children than ICD-10 with an anxiety disorder, with a higher concordance between DSM-IV-TR and the ICD-10 child section (F9) than with the adult section (F4) of the ICD-10. This result was found for all four investigated anxiety disorders. The results revealed
low to high levels of concordance and poor to good agreement between the classification
systems, depending on the anxiety disorder.

Conclusions

The two classification systems identify different children with an anxiety disorder.
However, it remains an open question, whether the research results can be generalized
to clinical practice since DSM-IV-TR is mainly used in research while ICD-10 is widely established in clinical practice in Europe. Therefore, the population investigated
by the DSM (research population) is not identical with the population examined using the ICD (clinical population).

Keywords:

Background

Mental disorders are classified by two major nosological systems, the International Classification of Diseases ICD,
[1] and the Diagnostic and Statistical Manual of Mental Disorders DSM,[2]. While the DSM is largely used for research purposes in Europe, European clinicians are mandated
to report ICD codes
[3]. Despite much effort to reduce the incompatibilities between the two classification
systems
[4], differences with respect to specific operationalization of many diagnoses still
exist between the current versions, the ICD-10[1], last revision in 1993, and the DSM-IV-TR[2], last revision in 2000. A main conceptual difference between the two classification
systems is how they differentiate anxiety disorders in adulthood and childhood. The
ICD-10 differentiates between anxiety disorders in childhood and in adulthood defining different
criteria, whereas for the DSM-IV-TR this separation no longer exists. The subdivision of child-specific anxiety disorders
is justified by the authors of the ICD-10 because they argue that emotional disorders in infancy (1) discontinue until adulthood,
(2) are rather reinforcements of normal developmental trends as independent, qualitatively
unique phenomena, (3) differ from those of anxiety disorders in adulthood, and (4)
cannot be clearly divided into more specific units, for instance phobic conditions
[5].

Several studies investigated the agreement (percentage of cases with the same diagnosis
on both classification systems) between various versions of the ICD and DSM as well as the concordance (percentage of cases with a positive diagnosis by both
classification systems out of all cases with a positive diagnosis by either system)
of mental disorders. The studies mainly focused on substance use e.g.,
[6-8], anxiety disorders, and affective disorders in adulthood e.g.,
[9-13]. The results of these studies show moderate to good agreements between the latest
versions of ICD and DSM. However, considerable discrepancies nevertheless exist between the two systems.

Focusing on mental disorders in children and adolescents, two studies investigated
the agreement between ICD and DSM diagnoses. Steinberger and Schuch
[14] examined the diagnostic concordance for 66 children with obsessive-compulsive disorder
(OCD) using semi-structured instruments, the International Diagnostic Checklists for
DSM-IV and ICD-10 IDCL,
[15]. They found evidence of poor agreement between the two classification systems. While
DSM-IV identified both children and adolescents with an OCD diagnosis, ICD-10 particularly diagnosed adolescents. Since the ICD-10 displayed an age-dependent concept of OCD, Steinberger and Schuch
[14] argued that the DSM-IV criteria diagnosing OCD in childhood are superior to those of the ICD-10. Sorenson, Mors, and Thomsen
[16] compared the two systems focusing on major depressive disorder, attention deficit
hyperactivity disorder, and oppositional defiant disorder in a sample of 199 child
psychiatric patients. The diagnoses were based on a semi-structured interview, the
Schedule for Affective Disorders and Schizophrenia for Children-Present and Lifetime
version [K-SADS-PL
[17]. Sorenson et al.
[16] found evidence of moderate agreement between the two systems. More children were
diagnosed with a major depressive disorder using the DSM-IV-TR than when the ICD-10 was applied. This discrepancy is mainly due to the fact that ICD-10 requires depressed mood to be largely uninfluenced by circumstances. Also more children
were diagnosed with ADHD according to the DSM-IV, because ICD-10 does not offer a diagnosis covering ADHD subtypes such as hyperactive/impulsive or
attention. The diagnosis for oppositional defiant disorder was interchangeable between
the two systems.

In summary, there is evidence that the concepts of the ICD and DSM differ, resulting in discrepancies in the classification of children. More specifically,
results of Sorenson et al.
[16] and Steinberger et al.
[14] provide preliminary evidence that the DSM diagnoses more children with a mental disorder than the ICD-10. However, to our knowledge, no study focusing on anxiety disorders, apart from OCD,
in children and adolescents has been conducted so far. The aim of the present study
was therefore to investigate the concordance of anxiety disorders in children and
adolescents established by the ICD-10 and the DSM-IV-TR. In addition, discrepancies at the diagnostic and the criterion level were determined
for separation anxiety disorder (SAD), specific phobia, social phobia, and generalized
anxiety disorder (GAD). Knowledge gained from this study may be essential for subsequent
revisions of the ICD-10 and DSM-IV-TR to reduce current differences between the two systems.

Method

Measures

Diagnoses were established with the Kinder-DIPS (Diagnostisches Interview bei Psychischen Störungen des Kindes- und Jugendalters), a structured diagnostic interview that is
designed to address both ICD-10 and DSM-IV diagnostic criteria in children and adolescents
[18]. The Kinder-DIPS consists of a child and a parent version (i.e., either the mother
or father or both together) and assesses all anxiety disorders, depression, attention-deficit
hyperactivity disorder, oppositional defiant disorder, sleep disorders, and eating
disorders. The Kinder-DIPS shows a good reliability for anxiety disorders (child version:
kappa = 0.88; parent version: kappa = 0.85) and other axis I disorders (child version,
kappa = 0.48– 0.88, parent version, kappa = 0.85–0.94)
[19].

Participants and procedure

We collected data from 468 interviews (210 child and 258 parent interviews), which
were conducted by seven psychologists (with a Master’s degree) and 28 Master’s students
of clinical psychology. All interviewers received official standardized training in
administering the Kinder-DIPS. Participants were recruited from the patient population
at child and adolescent psychiatric clinics (n = 135) and from a research study at the University of Basel (n = 164). Insufficient knowledge of the German language was an exclusion criterion.
The participating institutions recruited their patient samples. The patients at the
University of Basel took part in a research program for anxiety disorders. Therefore,
the recruitment at the University of Basel focussed on children with anxieties, especially
on children with separation anxiety disorders. This explains the high prevalence rates
of anxiety disorders as described in the result section. The interviewers administered
the Kinder-DIPS to 210 children aged 6 to 17 years (M = 10.87, SD = 2.78; 51.4% boys) and to 258 parents of children aged 4 to 17 years (M = 9.77, SD = 3.08; 51.2% boys). The variance in the number of children and parents is a result
of the fact that children can only be interviewed from the age of 6, whereas parent
interviews can be conducted already when children are 4 years of age. The interview
was part of the diagnostic assessment carried out at the participating institutions.
Prior to the interview, children and parents were informed about the interview process
and gave their written informed consent.

Statistical analyses

The data were analysed with the Statistical Package for Social Sciences (SPSS) for
Windows. We constructed 2x2 tables with the percentage of agreement for interrater
reliability and the comparison of ICD-10 (F4/F9) and DSM-IV-TR diagnoses for SAD (F93.0 vs. 309.21), specific phobia, phobic anxiety disorders of
childhood, respectively (F40.2/F93.1 vs. 300.29), social phobia (F40.1/F93.2 vs. 300.23),
and GAD (F41.1/F93.80 vs. 300.02). Kappa and Yule’s Y were calculated since kappa is not informative when base rates are low. Yule’s Y,
on the other hand, is considered more robust
[20]. Yule’s Y was calculated
[21] for base rates lower than 10%. For cases that were negative on one diagnostic system
and positive on the other, specific criteria causing the discrepancy were identified.
The level of significance was set to 5%. We omitted the sections of the interview
with missing values from further analyses. For the child interviews this resulted
in a sample size reduction from 210 to 202 for the analyses of SAD, to 198 for specific
phobia, to 186 for social phobia, and to 206 for GAD. For the parent interviews the
sample size was reduced from 258 to 257 for the analyses of SAD, to 249 for specific
phobia, to 228 for social phobia, and to 248 for GAD. The large sample size reduction
for the analyses of social phobia is due to the interview process. We established
a separate section for each diagnoses of social phobia (social phobia according to
F4 in the ICD-10, social anxiety disorder of childhood according to F9 in the ICD-10, and DSM-IV-TR criteria), since the criteria differ for these three diagnoses. The separation of the three
sections ensures an exact assessment of the criteria. If an interviewer did not go
through all three sections, because, for example, the criteria were not fulfilled
in one section, the comparison could not be made.

Results

Interrater reliability

Differences between ICD-10 and DSM-IV-TR diagnoses can be influenced by the reliability of the diagnoses. Therefore, we initially
tested interrater reliability.

Child interviews

The testing included 136 interviews for SAD, 133 interviews for specific phobia, 122
interviews for social phobia, and 138 interviews for GAD. All examined anxiety disorders
showed very good interrater reliabilities for ICD-10 as well as for DSM-IV-TR diagnoses: kappa/Yule’s Y > 0.81 for SAD, Yule’s Y > 0.86 for specific phobia/phobic anxiety disorder, Yule’s Y = 1.00 for social phobia, and Yule’s Y = 1.00 for GAD. These findings provide a sufficient basis for the research question
of this paper.

Parent interviews

We tested 169 interviews for SAD, 159 interviews for specific phobia, 142 interviews
for social phobia, and 159 interviews for GAD. All examined anxiety disorders showed
very good interrater reliabilities for ICD-10 as well as for DSM-IV-TR diagnoses: kappa > 0.83 for SAD, Yule’s Y > 0.88 for specific phobia/phobic anxiety disorder, Yule’s Y > 0.85 for social phobia/social anxiety disorder, and Yule’s Y = 1.00 for GAD. Again, these findings justify the further study of the research question
of this paper.

Comparisons between the ICD-10 and DSM-IV-TR

The following describes the ICD-10 and DSM-IV-TR point prevalence rates as well as the level of concordance for each diagnosis. Further,
we present criteria causing disagreements between the systems. A negative case (i.e.,
no diagnosis of disorders) may be identified, if several criteria are not fulfilled.
The results of the comparisons are presented in Table
1. The table shows the cases diagnosed as having no anxiety disorder by both systems
(DSM/ICD) (−/−) and those diagnosed with an anxiety disorder by either (−/+, +/−)
or both (+/+) systems. Furthermore, the percentage of agreement between the two systems
as well as the kappa and Yule’s Y coefficients of agreement are displayed.

Table 1.Cross-classification of all anxiety disorders determined by the DSM-IV-TR and ICD-10 for child and parent interviews

Separation anxiety disorder (SAD) ICD-10 F93.0 and DSM-IV-TR 300.21

Child interviews

We found 12.4% prevalence for the ICD-10 and 17.8% for the DSM-IV-TR diagnosis. Thirty-eight children met the criteria for SAD on either classification
system with a concordance of 63.9%. Two cases were positive on ICD-10 and negative on DSM-IV-TR. In one case this was due to the fact that the child did not exhibit three or more
characteristics of DSM criterion and in the other case because the child did not show clinically significant
impairment or distress (DSM criterion D). 16 children received a positive diagnosis with the DSM-IV-TR while the diagnosis based on the ICD-10 was negative: of these, 3 children lacked three or more characteristics of ICD criterion A, and in 13 children the onset of the anxiety was after the age of 6 (ICD criterion C).

Parent interviews

The prevalence for the ICD-10 was 29.2% and 36.2% for the DSM-IV-TR. Ninety-seven children were diagnosed with SAD on either classification system with
a concordance of 73.2%. Four children were positive on ICD-10 and negative on DSM-IV-TR because they did not show clinically significant impairment or distress (DSM criterion D). 24 children received a positive diagnosis with the DSM-IV-TR diagnosis while the ICD-10 diagnosis was negative. Two of the 24 children lacked three or more characteristics
of ICD criterion A while 6 children were diagnosed with a GAD (ICD criterion B). By 16 children the anxiety became evident after the age of 6 (ICD criterion C).

Specific phobia ICD-10 F40.2 and DSM-IV-TR 300.29

Child interviews

The ICD-10 prevalence was 7.1%, the DSM-IV-TR prevalence being 12.1%. Thirty-one children met the criteria for specific phobia
on either classification system with a concordance of 22.6%. Eight children received
a positive ICD-10 diagnosis while their DSM-IV-TR diagnosis was negative: of these, 2 children almost always never showed a fearful
reaction in the phobic situation (DSM criterion B), 5 children did not demonstrate clinically significant impairment or
distress (DSM criterion E), and one of the children had experienced fear for less than 6 months
(DSM criterion F). For 24 children the DSM-IV-TR diagnosis was positive and the ICD-10 was negative; 11 of the children did not fulfil the essential panic symptoms (ICD criterion B), and 13 children did not have significant emotional distress and insight
(ICD criterion C).

Parent interviews

Our analysis revealed a prevalence of 6.4% for the ICD-10 and 16.5% for the DSM-IV-TR. Forty-eight children met the criteria for specific phobia on either classification
system with a concordance of 18.7%. Seven of the children received a positive diagnosis
according to the ICD-10 while their diagnosis based on the DSM-IV-TR negative. Two of the seven children almost always never experienced a fearful reaction
in the phobic situation (DSM criterion B) and 5 children had no clinically significant impairment or distress
(DSM criterion E). The DSM-IV-TR diagnosis was positive for 43 children while they received a negative diagnosis based
on the ICD-10. 19 children of these 43 lacked the essential panic symptoms (ICD criterion B) and 24 children reported that they did not experience significant emotional
distress and insight (ICD criterion C).

Child interviews

The results showed a prevalence of 5.1% for the ICD-10 and 12.1% for the DSM-IV-TR. Twenty-eight children met the criteria for specific phobia on either classification
system with a concordance of 21.4%. Four children received a positive ICD-10 diagnosis while based on the DSM-IV-TR their diagnosis was negative. Three of these 4 children were positive on ICD-10 and negative on DSM-IV-TR since they almost always never showed a fearful reaction in the phobic situation
(DSM criterion B). For one child the duration of the fear was less than 6 months (DSM criterion F). Eighteen children were given a positive diagnosis according to the
DSM-IV-TR while their ICD-10 diagnosis was negative. Seventeen of the 18 children were not socially impaired (ICD criterion A) and 1 child was diagnosed with GAD (ICD criterion B).

Parent interviews

We found an ICD-10 prevalence of 6.0% and a DSM-IV-TR prevalence of 16.5%. Forty-two children met the criteria for specific phobia on either
classification system with a concordance of 33.3%. Only one case was positive on ICD-10 and negative on DSM-IV-TR because the child almost never showed a fearful reaction in the phobic situation
(DSM criterion B). Twenty-eight children were granted a positive DSM-IV-TR diagnosis, the ICD-10 diagnosis being negative. Twenty-six of the 28 children did not fulfil the criteria
for being socially impaired (ICD criterion A) while 2 children were diagnosed with GAD (ICD criterion B).

Social phobia ICD-10 F40.1 and DSM-IV-TR 300.23

Child interviews

Our results demonstrated an ICD-10 prevalence of 0.5% while prevalence of the DSM-IV-TR was 5.9%. Eleven children met the criteria for social phobia on either classification
system with a concordance of 9.1%. None of the children was positive on the ICD-10 and negative on the DSM-IV-TR. Thirteen children received a positive DSM-IV-TR diagnosis while being negative based on the ICD-10. Ten of the children lacked the necessary panic symptoms (ICD criterion B) while 3 children did not have significant emotional distress and insight
(ICD criterion C).

Parent interviews

The prevalence for the ICD-10 was 1.8% and 13.6% for the DSM-IV-TR. Thirty-two children met the criteria for social phobia on either classification
system with a concordance of 9.4%. One child was positive on ICD-10 and negative on DSM-IV-TR because of the lack of clinically significant impairment or distress (DSM criterion E). Positive DSM-IV-TR diagnosis and negative ICD-10 diagnosis was given to 45 children. Twenty-five of them did not demonstrate the necessary
panic symptoms (ICD criterion B) and 20 children lacked significant emotional distress and insight (ICD criterion C).

Child interviews

The prevalence for the DSM-IV-TR was 5.9%. Eleven children met the criteria for social phobia on DSM-IV-TR. None of the children received a positive diagnosis on ICD-10. Twenty-seven children received a positive DSM-IV-TR and a negative ICD-10 diagnosis. Eight children out of the 27 did not meet ICD criterion A, which requires social fear and avoidance, 2 children were not embarrassed
or worried about their behaviour toward strangers (ICD criterion B) and 11 children did not have clinically significant impairment or distress
(ICD criterion C). One child did not have satisfying relationships with family members
and friends (ICD criterion D), and for 5 children the onset of the anxiety was after the age of 6
(ICD criterion E).

Parent interviews

ICD-10 had a prevalence of 7.0% for and the DSM-IV-TR of 13.6%. Thirty-six children met the criteria for social phobia on either classification
system with a concordance of 30.6%. All five children who were positive on ICD-10 and negative on DSM-IV-TR did not display fear and humiliation (DSM criterion A). Thirty-six children received a positive DSM-IV-TR diagnosis and were diagnosed negative according to ICD-10. From the 36 children, 12 children did not display social fear and avoidance (ICD criterion A), 2 children were not embarrassed or worried about their behaviour toward
strangers (ICD criterion B), 16 children did not have clinically significant impairment or distress
(ICD criterion C), 2 children did not have satisfying relationships with family members
and friends (ICD criterion D), and for 3 children the onset of the anxiety was after the age of 6
(ICD criterion E), while 1 child was diagnosed with GAD (ICD criterion F).

Generalized anxiety disorder (GAD) ICD-10 F41.1 and DSM-IV-TR 300.02

Child interviews

The prevalence for the ICD-10 was 1.5% and for the DSM-IV-TR 4.9%. Eleven children met the criteria for GAD on either classification system with
a concordance of 18.2%. One child was positive on ICD-10 and negative on DSM-IV-TR because the child did not exhibit the required symptoms (DSM criterion C). All 8 children, who were positive on DSM-IV-TR and negative on ICD-10, did not display the required symptoms (ICD criterion B).

Parent interviews

The prevalences for the ICD-10 and for the DSM-IV-TR were 3.6% and 5.6% respectively. Nineteen children met the criteria for GAD on either
classification system with a concordance of 21.1%. Nine children were diagnosed positive
on the ICD-10 and negative on the DSM-IV-TR. Two out of the 9 children had no difficulty controlling worry (DSM criterion B), 4 children lacked the required symptoms (DSM criterion C), and 3 children did not have clinically significant impairment or distress
(DSM criterion E). All 10 children, who were positive on DSM-IV-TR and negative on ICD-10, did not demonstrate the required symptoms (ICD criterion B).

Generalized anxiety disorder (GAD) ICD-10 F93.80 and DSM-IV-TR 300.02

Child interviews

We found a prevalence of 1.0% for the ICD-10 and 4.9% for the DSM-IV-TR. Ten children met the criteria for GAD on either classification system with a concordance
of 20%. Ten children received a positive diagnosis based on the DSM-IV-TR and were diagnosed negative on the ICD-10. Eight out of these 10 children did not display the required symptoms (ICD criterion C) and 2 children did not show worry in at least two situations (ICD criterion D).

Parent interviews

The ICD-10 prevalence was 4.4% for and the prevalence for DSM-IV-TR was 5.6%. Fourteen children met the criteria for GAD on either classification system
with a concordance of 78.6%. Three children did not exhibit the required physical
symptoms (ICD criterion C), while their DSM-IV-TR diagnosis was positive and ICD-10 diagnosis was negative.

Discussion

The present study describes an investigation of concordance between ICD-10 and DSM-IV-TR diagnoses of anxiety disorders in children and adolescents, specifically for separation
anxiety disorder (SAD), specific phobia, social phobia, and generalized anxiety disorder
(GAD). The results indicated low to high levels of concordance and poor to good agreement
between the classification systems, depending on the anxiety disorder. As seen by
the high interrater reliability of the established diagnoses in the present study,
the disagreement between the two systems is unlikely to be the result of unreliable
diagnostic processes.

Regarding the child interviews, the agreement between diagnoses established with the
ICD-10 and the DSM-IV-TR was good for SAD (kappa = 0.71), unsatisfactory for specific phobia (F40.2: Yule’s
Y = 0.52) and for phobic anxiety disorder of childhood (F93.1: Yule’s Y = 0.58), and satisfactory for GAD (F41.1: Yule’s Y = 0.75). For social phobia (F40.1), social anxiety disorder of childhood (F93.2),
and GAD (F93.80) no cases were diagnosed as positive only by the ICD-10.

The results for the parent interviews show very good agreement for SAD (kappa = 0.77),
and satisfactory agreement for phobic anxiety disorder of childhood (F93.1: kappa
= 0.45) and social anxiety disorder of childhood (F93.2: kappa = 0.41). The agreement
was poor for specific phobia (F40.2: kappa = 0.25), and unsatisfactory for social
phobia (F40.1: Yule’s Y = 0.64) and GAD (F41.1: Yule’s Y = 0.62). For GAD (F93.80), no cases were diagnosed as positive only by the ICD-10.

Good agreement between the ICD-10 and DSM-IV-TR was found for all negative diagnoses. Focussing on the positive diagnoses, the DSM-IV-TR consistently classified more children with an anxiety disorder than the ICD-10 for SAD, GAD, social and specific phobia. Results are comparable to previous studies
comparing ICD-10 and DSM-IV diagnoses of mental disorders in children and adolescents
[14,16].

The concordance was higher for the DSM-IV-TR and the ICD-10 child section (F9) than for the ICD-10 adult section (F4), especially for the parent interviews. The highest level of concordance
was found for SAD (child interviews: 63.9%; parent interviews: 73.2%) and GAD (F93.80;
parent interviews: 78.6%). However, there was only a low level of concordance for
GAD (F93.80) in the child interviews (20%) and also for GAD (F41.1) in the child and
parent interviews (18.2%, 21.1%). This result is due to the stricter criterion C in
the ICD-10 than in the DSM-IV-TR requiring three symptoms to be associated with anxiety and worry (e.g., muscle tension,
sleep disturbances, restlessness, irritability). However, in DSM-IV-TR only one physical
symptom for a diagnosis of GAD in children is required. The revision of the DSM-V
(
http://www.dsm5.orgwebcite) points out that there is limited evidence for the threshold of three or more symptoms
associated with anxiety and worry. Therefore, it is proposed that, even for adults,
one or more associated symptoms should be sufficient for a diagnosis of GAD. A low
level of concordance was found for specific phobia (F40.2), phobic anxiety disorder
of childhood (F93.1), social phobia (F40.1), and social anxiety disorder of childhood
(F93.2) in the child and parent interviews.

Discrepancies on criterion level between the ICD-10 (F4) and the DSM-IV-TR

Regarding discrepancies on criterion level between the ICD-10 (F4) and the DSM-IV-TR, the low concordance for specific and social phobias was particularly due to the ICD-10 criterion requiring significant emotional distress and insight. Thereby, the demand
for insight was mainly not fulfilled. When ICD-10 positive cases were negative on the DSM-IV-TR, the main reason was that the DSM-IV-TR criterion requires clinically significant impairment or distress. Some children and
parents denied impairment or distress due to the fear or avoidance as defined in the
DSM-IV-TR, however, at the same time they indicated significant emotional distress concerning
the panic symptoms described in the ICD-10.

Discrepancies on criterion level between the ICD-10 (F9) and the DSM-IV-TR

Discrepancies in SAD diagnoses were mainly due to ICD-10 criterion B requiring the exclusion of GAD and criterion C requiring onset before
the age of 6. For SAD, DSM-IV-TR requires an onset before age 18 years. DSM-V is considering deleting the specifier “early onset before age 6 years” as there is
no evidence to justify such a specifier (
http://www.dsm5.orgwebcite). Furthermore, the retrospective NCS-R study showed a median age of onset for SAD
at 7 years of age
[22] supporting a less strict criterion for SAD in ICD-10.

When the DSM-IV-TR diagnosis was negative, this was mainly due to the criterion D requiring clinically
significant impairment or distress. With regard to specific and social phobias, discrepancies
were in particular due to the criteria defining the fear and impairment. For specific
phobia in the ICD-10, criterion A requires fear with social impairment, whereas the DSM-IV-TR criterion A requires only fear. The type of impairment is more widely defined in
the DSM-IV-TR (criterion E; e.g. impairment in social, occupational, or other important areas of
functioning). For social phobia, in the ICD-10 social fear and avoidance are required (criterion A), whereas in the DSM-IV-TR social fear and feelings of humiliation are required (criterion A). Further, the
feature of impairment is much more clearly defined in the ICD-10 (criterion C) than in the DSM-IV-TR (criterion E). The main reason for a negative DSM-IV-TR diagnosis was criterion A (marked and persistent fear of one or more social or performance
situations).

In sum, the low level of concordance is particularly due to the two systems using
different definitions of common features. More specifically, the definitions of (specific
and social) fear and impairment differ significantly.

Kendell
[23] recommends that minor points of difference between the two classification systems
should be revised to become identical, and if the differences are substantial, the
validity of each system should be assessed. The results of the present study indicate
that concordance between the child section (F9) in the ICD-10 and the DSM-IV-TR might be improved by a less strict formulation of the ICD-10 criteria. More specifically, the onset of SAD, the definition of impairment and insight
for specific and social phobia, and the required number of essential symptoms associated
with anxiety and worry for GAD should be changed in ICD-11. In addition, the conceptualization of GAD (F93.80) in the ICD-10 is an important issue to consider. According to the ICD-10, GAD is conceptualized higher in the hierarchy of anxiety disorders in childhood,
since a diagnosis of GAD is an exclusion criterion for other anxiety diagnoses in
childhood (F9). However, there are no empirical studies to show that diagnoses of
SAD, specific, and social phobia could not be comorbid with GAD. Therefore in ICD-11, it should be possible to assign comorbid anxiety disorders with GAD. However, it
has to be acknowledged that the diagnosis of GAD is considered difficult and not reliable,
due to high rates of coexisting disorders and the overlap in symptomatology, e.g.,
depression and other anxiety disorders
[24], therefore diagnostic criteria will most likely be changed again for DSM-V. How comorbidity is dealt with by the DSM-IV-TR and the ICD-10 is actually quite
similar, since both systems with their descriptive approaches allow multiple diagnoses
[2].

The results of the present study support the proposed change in DSM-V to delete the age criteria for SAD. Regarding the discussion to separate functional
impairment and diagnoses
[25], the good agreement for all negative diagnoses in this study underlines the importance
of integrating the criteria of overall impairment and distress in assigning diagnoses.

It is important to note that the ICD is used in clinical practice in Europe, whereas the DSM is the most frequently used system for research purposes
[26]. The differences between the two systems lead to different diagnoses in clinical
practice and research. Knowledge gained from research may therefore not be directly
applicable to clinical practice. If the population investigated by the DSM (research population) is not identical with the population examined by the ICD (clinical population), it is open to question whether the results from research can
be directly applicable to clinical practice. This is an important issue considering
the fact that psychotherapy and psychopharmacology treatment research is usually based
on DSM diagnoses. The ICD-10 differentiation between anxiety disorders in adulthood and childhood leads to diagnostic
problems in clinical practice; for instance it is unclear which diagnoses a 17-year
old adolescent, who fulfils criteria for both specific phobias (F4 and F9), should
receive. In addition, the argument of discontinuing disorders of ICD-10 is not empirically supported. On the contrary, several studies indicate that anxiety
disorders in childhood are a major risk factor for the development of further mental
disorders
[27-29]. Suggesting that ICD-10 classifies fewer children with anxiety disorders than DSM-IV-TR, indicates that these children are not recognized, and therefore they remain untreated
and are at risk to develop further mental disorders.

Some shortcomings of the present study have to be acknowledged. The small sample size,
with rare positive diagnoses, especially for social phobia and GAD, should be mentioned
as a limitation. The sample size may have been too small to detect rarely occurring
discrepancies. To confirm the reported results, studies with a larger sample size
including more positive diagnoses are necessary. The focus of the present study was
on concordance and discrepancies on the criterion level and no conclusions about the
validity of the diagnoses were drawn. It would be useful for future research to examine
diagnostic validity, in particular for diagnostic categories with low concordance.

In sum, the low level of concordance is due to substantial differences in criteria
for anxiety disorders between the classification systems. The two systems contain
different concepts, and therefore classify different children. This is problematic,
as children with significant problems and impairments may remain undiagnosed and therefore
untreated. Consequently, the goal for both DSM-V and ICD-11 should be to diagnose
children as adequately as possible, get them into treatment and so reduce further
distress. Therefore, each diagnostic criterion should be empirically investigated.
In addition, comparable diagnostic criteria would lead to consistent prevalence rates
regardless of the classification system used.

Competing interest

The authors declare that they have no competing interests.

Authors’ contributions

CA carried out interviews, the analyses, and drafted the manuscript. AS has made substantial
contribution to acquisition of data. TI contributed to acquisition of data, the drafting
and revising of the manuscript. MN participated in the interpretation of the data
and revising the manuscript. SS made substantial contributions to the design of the
study, the interpretation of the data, drafting and revising the manuscript. All authors
read and approved the final manuscript.

Acknowledgements

This study was funded by the Swiss National Science Foundation (SNF) (project no.
PP001-68701; 105311-116517/1). The Article processing charge (APC) of this manuscript
has been funded by the Deutsche Forschungsgemeinschaft (DFG).

Wacker HR, Müllejans R, Klein KH, Battegay R: Identification of cases of anxiety disorders and affective disorders in the community
according to ICD-10 and DSM-III-R by using the composite international diagnostic
interview (CIDI).