Diabetes, paralysis, being bed ridden and other conditions can result in chronic wounds that fail to heal, with significant personal consequences for patients and an annual cost of £4.5-5.1 billion annually (Guest et al., 2015) to the National Health Service.

Animals including humans make choices continuously based in past experience, present sensory input and internal state. A major goal in neuroscience is to identify the neural circuits underlying goal directed choices and to elucidate the neural computation driving goal orientated behaviour.

Neurons are morphologically very complex cells with large arborisations that can extend for several millimetres. Communication between neurons relies on action potential driven release of neurotransmitter at specialised sites called synapses.