NIH Rare Diseases:41 Wolff-parkinson-white syndrome is a condition that disrupts the heart's normal rhythm (arrhythmia). people with wolff-parkinson-white syndrome are born with a heart abnormality that affects the coordinated movement of electrical signals through the heart. this abnormality leads to an abnormally fast heartbeat (tachycardia) and other arrhythmias. in most cases, the cause of wolff-parkinson-white syndrome is unknown. a small percentage of cases are caused by mutations in the prkag2 gene. these cases appear to be inherited in an autosomal dominant manner.
last updated: 12/31/2012

MalaCards based summary: Wolff-Parkinson-White Syndrome, also known as anomalous atrioventricular excitation, is related to hypertrophic cardiomyopathy and tuberous sclerosis, and has symptoms including stroke, cardiomyopathy and sudden cardiac death. An important gene associated with Wolff-Parkinson-White Syndrome is PRKAG2 (protein kinase, AMP-activated, gamma 2 non-catalytic subunit), and among its related pathways are Heart Development and Regulation of autophagy. The drugs adenosine and adenosine monophosphate and the compounds a 769662 and dorsomorphin dihydrochloride have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and spinal cord, and related mouse phenotypes are muscle and no phenotypic analysis.

Genetics Home Reference:21 Wolff-Parkinson-White syndrome is a condition characterized by abnormal electrical pathways in the heart that cause a disruption of the heart's normal rhythm (arrhythmia).

Wikipedia:63 Wolff?Parkinson?White syndrome (WPW) is one of several disorders of the conduction system of the heart... more...

Body surface distribution of abnormally low QRST areas in patients with Wolff-Parkinson-White syndrome. Evidence for continuation of repolarization abnormalities before and after catheter ablation. (8252678)

Hirai M.... Kondo T.

1993

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Effects of flecainide on atrial electrophysiology in the Wolff-Parkinson-White syndrome. (1509996)