Born in Cape Town, South Africa in 1972, Prangley grew up on a small farm tending horses, sheep, and chickens with his mother, father, brother, and sister. When Trevor was only 4 years old, his father asked him if he wanted to sign-up for wrestling classes at a local club. He didn't know it then, but that was the beginning of a long career in wrestling.

Trevor wrestled throughout his youth in South Africa. He won numerous regional and provincial titles and at age 23 captured the national title. This brought him close to his goal of making the South African Olympic team, but he lost the qualifying match in overtime and had to settle for alternate status. Disappointed and dissatisfied with the level of training he was receiving, Trevor decided to go to the United States to further his Olympic dreams.

He left his family behind and headed to Coeur d'Alene, Idaho. His hope was to make the lineup and secure a scholarship at North Idaho College (NIC), a local community college. This gamble paid off. Trevor received All-American status both years at NIC. Unfortunately, during the final match of his second year while ahead on points, Trevor tore his ACL and placed runner up. Frustrated that his eligibility was gone and he had not reached his goal of becoming a national champion, Trevor considered returning home to South Africa. Those thoughts soon disappeared as he began to receive numerous scholarship offers to continue wrestling at four-year schools. He was now motivated to begin aggressive rehab.

Despite doctor's predictions that it would be nine months before being able to wrestle again, Trevor found a local Jiu-Jitsu school and began to train. Jiu-Jitsu enabled him to stay in shape and still have something to compete in while recovering. Just six months later, in 1998, he had his first amateur mixed martial arts fight. Even though he lost this fight to decision, he realized that mixed martial arts was the sport for him. He canceled his plans to resume college wrestling and went on a 19 fight winning streak before turning pro in 2001.

His pro-career started as a Light Heavyweight at 205 pounds. He achieved six straight wins before fighting Renato Sobral, his toughest fight to date. It was losing this fight that made Trevor decided to move to middleweight 185 lbs. He decided to drop to a middleweight where he could feel more comfortable and strong. This proved to be a good decision. Trevor won his first fight at 185 pounds over Andrei Semenov of Russia and secured a fight in the UFC.

He made his debut in the UFC at UFC 48, defeating Curtis Stout by submission. He is currently 2-2 in the organization, including a close decision loss to Jeremy Horn at UFC 56. Prangley then went on to lose to Chael Sonnen at Ultimate Fight Night 4.

Leaving the UFC, Prangley then fought for several organizations, including Bodog Fight, where he qualified for the USA vs. Russia card on the reality show, and defeated Andrei Seminov for a second time at the event.

Prangley fought Tony Lopez for the vacant KOTC Light Heavyweight Championship at KOTC: Vigilante. The fight was stopped in the fourth round after Lopez landed an illegal knee to Prangley's head and Prangley could not continue even after the 5 minutes allowed to recover. The bout then went to a technical decision where the judges scored a Majority Decision victory for Prangley.[6]

Prangley made his fourth title defense when he faced Jared Torgeson at KOTC: Double Impact on 4 October 2013. He won the fight via unanimous decision.[7]

In his fifth title defense, Prangley faced Jared Torgeson in a rematch at KOTC: Steadfast on 14 August 2014. Prangley won via KO in the first round.[8]

In his sixth title defense, Prangley faced Richard Blake at KOTC: Tactical Strike on 13 November 2014. He successfully defended his title, winning by submission early in the first round.[citation needed]