While picking games against the spread is a tough challenge, the rewards can be incredible and it’s always fun to place a couple friendly wagers on the games. Week 6 is no different, so let’s take a look at the current lines and predict some winners.

*Point spreads via ScoresAndOdds.com

TENNESSEE TITANS (+5.5) over Pittsburgh Steelers

While the Titans have been a punching bag this season, they’ll come to play against a Steelers team that is overrated by the public.

The reality is both teams have just one win against the spread so far in 2012, which makes taking the points with the home team the safest play in this one.

Cincinnati Bengals (-2.5) at CLEVELAND BROWNS

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Cincy isn’t the greatest team, but they are a much more reliable play than the 0-5 Browns. After suffering a let down in Week 5 against the Miami Dolphins, they’ll beat up on a divisional rival and cover this spread.

Watch out if this line moves to three or above, as it becomes a much more risky proposition.

Indianapolis Colts at NEW YORK JETS

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Kansas City Chiefs at TAMPA BAY BUCCANEERS

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ATLANTA FALCONS (-9) over Oakland Raiders

The Falcons have been a revelation through five games, going undefeated and absolutely destroying some of their weaker foes.

Considering how anemic the Raiders offense is and the travel they will have to undergo in order to play in this 1:00 p.m. EST game on the East Coast, it’s safe to lay nine points and watch the Dirty Birds pull away with a huge win.

BALTIMORE RAVENS (-3.5) over Dallas Cowboys

Baltimore has yet to lose at home, although it has been involved in a number of close games so far.

The main reason to choose them and lay the points against the Cowboys is Tony Romo’s poor play against the top secondary units he has faced. The Ravens possess some solid corners and an elite safety in Ed Reed, which should help swing this game and allow Baltimore to win by at least a TD.

Detroit Lions (+5) over PHILADELPHIA EAGLES

While the Eagles offensive woes are well publicized, they’ve managed to win three close games.

However, against the spread, Philly just isn’t worth trusting in this contest. They have a combined margin of victory of four points in those three games, less than they are laying against Detroit.

The Lions are a far cry from a good team this year, but they’ll make this one close and cover.

MIAMI DOLPHINS (-3.5) over St. Louis Rams

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Both of these squads are unpredictable, but we have to take the Dolphins at home here.

The Rams aren’t the same team away from the Edward Jones Dome, and the ‘Phins have been surprisingly competitive in their two Sun Life Stadium games on the way to a 2-3 record.

St. Louis has yet to cover a spread at +3.5 or higher on the road, so lean towards Miami.

New England Patriots (-4) at SEATTLE SEAHAWKS

It’s extremely hard to lay four points with an East coast team travelling all the way to Seattle (where the Seahawks are 2-0 ATS and SU), but the Patriots are simply a more dominant squad.

Bill Belichick has his roster coached up and will have them prepared to play on Sunday, despite the jet lag and raucous home crowd. They win this by at least one touchdown.

Buffalo Bills (+5) at ARIZONA CARDINALS

Arizona was the surprise team of the season until collapsing against the Rams on Thursday Night Football during Week 5.

Now they get to stay home in the desert and host the lowly Bills. Buffalo will take advantage of the major flaws that St. Louis revealed on the Cards’ offensive line and make this a tightly contested game that gets decided by a field goal or less.

Minnesota Vikings at WASHINGTON REDSKINS

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SAN FRANCISCO 49ers (-5.5) over New York Giants

The rematch of 2011’s NFC Championship will go in the Niners favor. They are fortunate enough to host the banged-up Giants in San Francisco and will come out ahead by pounding the rock and blanketing the G-Men receivers.

It should be close for most of the contest, but San Fran pulls ahead with a late TD and keeps Eli Manning from engineering another fourth quarter comeback.

Green Bay Packers (+5) over HOUSTON TEXANS

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It’s tough to bet against Houston, but they failed to cover the spread on Monday Night Football vs. the lowly New York Jets and are facing a reeling Green Bay team with its back against the wall.

Expect Aaron Rodgers to come out firing, avoiding the pass rush and making things happen for a surprise, upset victory.

Denver Broncos (+2) over SAN DIEGO CHARGERS

Peyton Manning suffered a loss to Tom Brady and the New England Patriots this past Sunday, but will get his revenge against a new divisional rival this coming Monday.

Take the points or play the Broncos ML, because they are winning this straight up in a blowout. Never bet against Peyton in a primetime game.