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microcirculation test in healthy children and in childhood rheumatic diseases

microcirculation test in healthy children and in childhood rheumatic diseases: a prospective single blind observational study Free

Abstract

Objectives: To develop an objective method of nailfold capillaroscopy (NFC), applicable to a wide age range of paediatric patients. To compare the morphological characteristics of the nailfold capillaries in different rheumatology patient groups and controls.

Methods: A colour digital video camera attached to a stereomicroscope was used to capture nailfold capillary images. Computerised image processing was used to analyse and store data. Subsequent quantitative and qualitative morphological analysis was performed in the following paediatric patient and control groups: 18 children with connective tissue diseases (CTD: juvenile dermatomyositis, systemic sclerosis, and undifferentiated connective tissue disease), eight with systemic lupus erythematosus, nine with primary Raynaud’s disease, three with primary vasculitis, 15 with juvenile idiopathic arthritis, 17 healthy children and 20 healthy adults. Images were analysed by a single assessor who was unaware of the patient details.

Results: The NFC technique was simple to perform and gave reproducible results, although some intra- and intersubject variation was noted. Capillary density and width was age related, with younger children having fewer and wider capillaries than older children and adults. Linear capillary density was significantly higher in healthy adults (mean (SD) 8.6 (1.6) capillaries/mm) compared with healthy children (HC 6.9 (0.9) capillaries/mm). The group with CTD had the most abnormal findings, with lower linear density (4.9 (1.7) capillaries/mm) and increased capillary loop width (10.7 (7.3) mm) compared with HC (3.5 (1.7) mm). In addition, 11/18 (61%) patients in the CTD group had more than two definitely abnormal capillaries in at least two nailfolds, an abnormality not seen in other subjects. Two qualitative measures, the degree of avascularity and general disarrangement of capillary pattern, were more commonly observed in the CTD group than in HC. The proportion of tortuous capillaries did not differ significantly between study groups.

Conclusions: This study is unique in measuring objective quantitative and qualitative parameters of the nailfold vasculature across a wide spectrum of age and disease. Differences in capillary morphology and frequency in children with CTD compared with other paediatric diseases and healthy controls were demonstrated. In the clinical situation, an assessment of the general degree of disarrangement may offer a fast tool for assessment of the nailfold vasculature which correlates well with NFC data.

How to read microcirculation test’s Microcirculation?

How to read microcirculation test’s Microcirculation?

It is recommended to prepare 1 sachet OLE with 200ml cold water and mix well with shaker. Consume it within 30 mins after preparation for better outcome.
It is not recommended for pregnant women, people with hemorrhagic stroke, patient who had just undergo surgery or people with wound.

It is not recommended to store the product in humid, high temperature or sun light exposure environment.

Please refer to nutritionist for those with special conditions or chronic diseases.

The condition of erthrocyte aggregation is more severe when the grade becomes higher. In addition of white microthrombus, blood flow is gradually reduced. All of these conditions indicate increased blood viscosity and easier to get angina, antherosclerosis, coronary heart disease, myocardial infarction, diabetes millitus etc.

Who and who need the microcirculation test device?

Who and who need the microcirculation test device?

Doctors: for private practice for preventive diagnostics
Preventive and diagnostic centers: as the main health scan and diagnosis equipment
Nutritionists: alternative and preventive medicine
Food supplements companies/distributors (Heel, NSP, Tiens, Dr.Nona and others)
Manufacturers of cosmetics, foodstuffs and various kinds of drugs: for identifying of optimal ingredients and for evaluation tests of their products
Beauty salons and health centers: for adding a new high-price, in-demand service to their business
Individual entrepreneurs and investment companies: to open a recession-proof, turn-key business that can start generating you profits right away. We offer assistance to our customers in setting up their private diagnostic center
Personal use – help yourself

What is microcirculation test Features?

What is microcirculation test Features?
1 It is not a invaded method to inspect the blood micro-circulate situation for the body.
2 The blood micro-circulate inspect the health situation by view perspective.
3 It is a contact process. It can search the tip blood capillary position in 5 second. Easy operation (not traditional XY goods)
4 The micro-image is stable, clear and not move for contact process.
5 360 times, high definition lens for micro-circulate machine
6 Light frame and easy to carry
7 Portable light design(250g)
8 The lens can be exactly adjusted a focal distance to make the image clear
9 Lens with LED light, the light can throw straight on a target.
（1）Can be observed in 5 seconds microvascular circulation, simple operation, fast.
（2）Microscopic displays image stability, clear and not shake.
（3）3400 times of microcirculation for high resolution microscopy.
（4）Handheld ultra lightweight design, make observation more action.
（5）With micro focus wheel, can adjust the focal length, more convenience.
（6）Inner objective with LED cold light，can provide accurate projection illumination on the target.
（7）Using non-intrusive way, observing blood microcirculation status in a timely manner.
（8）Can observation microcirculation For any parts of body.

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