Ageless Forever Anti-Aging News Blog

If you are following the anti-aging news, you’ve heard about the supposed benefits of chronic calorie restriction for increasing longevity. These claims are based on research done in various species such as flies, worms and mice.

Here I will explain that chronic calorie restriction makes it impossible to implement and reap the health benefits of an active lifestyle with regular exercise, and causes severe health consequences for humans.

While animal studies can and do shed light on what’s going on at mechanistic level, we have to be very careful and resist the temptation to extrapolate results from animal experiments to humans.

Here I will make the case that chronic calorie restriction actually counteracts the prospects of a healthy vital long life.

The science of aging is moving forward as scientists are elucidating the biology of aging. The ultimate goal is to develop treatments that delay aging, and in so doing, delay the development of aging-related diseases.[1]

Aging is the greatest risk factor for the majority of chronic diseases that are driving morbidity and health costs [2], but the aging process can be delayed with lifestyle (exercise and nutrition), genetics, and pharmacologic approaches.[3-8]

The so called “geroscience hypothesis” (“gero” is short for gerontology, which is the scientific study of the process of aging and its consequences) holds that treatments that are targeting fundamental processes of aging may delay, prevent, alleviate, or reverse a wide range of diseases and conditions for which age is the primary non-modifiable risk factor.[1] Interventions that target fundamental aging processes have the potential to transform human health and health care.[9]

Excitement is now high because time has come for the first study to test the effect of metformin on aging-related outcomes in humans and see if it qualifies as an "anti-aging pill"...