Proper Use

Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance of side effects.

This medicine comes with a Medication Guide. Read and follow the instructions carefully. Ask your doctor if you have any questions.

It is important that you or your child follow any special diet instructions from your doctor, such as using a low-protein diet. If you have any questions about this, check with your doctor.

Use an oral syringe or dosing cup to measure your dose. You may also give this medicine with a nasogastric tube or gastrostomy tube (g-tube).

To use the oral liquid with a nasogastric tube or g-tube:

Use an oral syringe to measure your dose and place it on the tip of the nasogastric tube or g-tube.

Inject the medicine into the tube.

Flush the tube with 30 mL of water to rinse all of the medicine into the stomach.

Rinse the tube again with additional 30 mL of water to clear the tube.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral dosage form (liquid):

For treatment of urea cycle disorders:

For patients not on phenylbutyrate treatment:

Adults, teenagers, and children 2 years of age and older—Dose is based on body size and must be determined by your doctor. The dose is 4.5 to 11.2 milliliters (mL) per square meter (m[2]) per day and divided into 3 equal doses. Your doctor may adjust your dose as needed. However, the dose is usually not more than 17.5 mL per day.

Children 2 months up to 2 years of age—Use and dose must be determined by your doctor.

Children younger than 2 months of age—Use is not indicated.

For patients switching from sodium phenylbutyrate to Ravicti™:

Adults, teenagers, and children 2 years of age and older—The dose is the total daily dose of sodium phenylbutyrate that you are already taking multiplied by 0.8 and divided into 3 equal doses. Your doctor may adjust your dose as needed. However, the dose is usually not more than 17.5 milliliters (mL) per day.

Children 2 months up to 2 years of age—Use and dose must be determined by your doctor.

Children younger than 2 months of age—Use is not indicated.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.