In February 1712, his wife contracted measles and died on the 12th of that month.

The Duke of Burgundy, who dearly loved his wife and who had stayed by her side throughout the fatal illness, contracted the disease and died on 18 February, six days after her at the Château de Marly. Both of his sons also became infected, the eldest, Louis, Duke of Brittany, the latest in a series of Dauphins, succumbed to it on 8 March. The only one to survive was the two-year old Duke of Anjou, the future King Louis XV of France.