We report a case of bowenoid papulosis in a patient with acquired immunodeficiency syndrome that was successfully treated with local applications of cidofovir in Beeler base. This treatment should be confirmed as a valuable nonagressive therapy for such potentially invasive viral-induced cell proliferation.

A 38-year-old homosexual man with a 10-year history of human immunodeficiency virus and an 8-month history of acquired immunodeficiency syndrome presented with a fibrotic lesion of the penis in June 1996. His medical history revealed that he had been diagnosed as having herpes zoster in 1992. He was also known to be positive for hepatitis B antigen. In 1995, he was treated for clinical Pneumocystis carinii pneumonia. In October 1995, treatment with zidovudine and zalcitabine was initiated (CD4 cell count, 22/µL), followed by zidovudine and lamivudine (CD4 cell count, 49/µL) in April 1996 and by zidovudine, lamivudine, and stavudine (CD4 cell count, 17/µL) in June 1996 (Figure 1). At that time, he presented with a fibrotic lesion of the penis and was treated with acyclovir (800 mg 5 times per day) for possible herpes simplex and with ceftriaxone sodium (4 g/d) for possible syphilis. Serologic tests for Treponema pallidum hemagglutination, the results of which were previously negative, revealed a titer of 1:80.