Situational items:

Runes:

Masteries

Abilities

Tips

Try to avoid being in the center of Ziggs’ ultimate, as it deals more damage in the center.

Avoid stepping on Ziggs’ mines! They will deal damage as well as slow you, making it easier for him to land more skills.

Avoid Staying near of minions, so he can’t use is bomb on them and damage you at the same time.

If you’re lucky to play an assasin agaisnt him (Zed, Kha’Zix, Yasuo, Fizz…) Stay pasive at the very early game. When you have your combo dont go mad on him, let your lane push a bit, kill his front lane minions so he approaches to you and attack him.

Focus him in teamfights, because he is able to deal massive damage to multiple champions at once.