Advanced Imaging for Glaucoma (AIG) is a multi-center bioengineering partnership sponsored by the National Eye Institute, one of the National Institutes of Health (NIH).

The goal of this partnership is to develop advanced imaging technologies that can improve the detection and management of glaucoma. Currently-employed advanced imaging devices include optical coherence tomography, scanning laser polarimetry and scanning laser tomography. The imaging technologies will be evaluated in a longitudinal 5-year clinical trial. The study subjects will include patients with normal eyes, patients with glaucoma, and individuals at risk for developing glaucoma.

ANNOUNCEMENTS - AIGS comes to an end

The Advanced Imaging for Glaucoma Study officially ended on August 31, 2013. As principal investigator, Dr. Huang would like to thank the participants for their commitment to the project.

With your participation, we were able to evaluate and compare the diagnostic accuracy of the eye measurements made by various imaging technologies. We learned that diagnosis could be improved by combining measurements from different parts of the eyes that were affected by glaucoma – the optic disc, nerve fiber layer, and macular ganglion cell complex. And we found that these imaging results could help predict the development of glaucoma and its subsequent progression.

Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science and Research Lab of Electronics, Boston, Massachusetts

Resource center:

Cleveland Clinic Foundation, Cleveland, Ohio

Specific Aims

The specific aims of the AIG clinical studies are to:

1. Predict the development of visual field (VF) abnormalities in individuals at risk for developing glaucoma based on anatomic abnormalities detected by advanced imaging;

2. Predict the development of VF abnormalities in individuals at risk for developing glaucoma based on anatomic changes detected between successive advanced imaging tests; and

3. Determine the sensitivity and specificity of a glaucoma diagnosis based on advanced imaging tests.

Organization

The coordinating center for the AIG partnership is located at the Oregon Health & Science Unversity (OHSU). There are a total of four centers that will be conducting the AIG clinical study, two basic science and engineering centers that will develop the advanced imaging instruments and conduct laboratory studies on glaucoma and one resource center.