Making sense in a time when Discovery science is rushing ahead of hypothesis driven science is not easy, especially when this new science is making mega "cents" – billions of dollars. And a time when the nature of truth (from one to many), nature (seen as designable instead of God made or to live in peace with), reality (challenged by quantum and miniaturized by nano) and society (connected via new digital technologies) are all undergoing revolutions that promise to make all of us strangers in a strange land, reason is hard to come by. The dot.com boom is certainly being followed by revolutions in nano-medicine, pharmco-genomics and artificial intelligence …to mention a few of the forces changing health care. The claims are grand.