Six Senses hotels has set sail from Asia and arrived on European shores. Its destination: Portugal's Douro Valley. New York-based Clodagh Design has transformed a 19th-century manor house, set among vineyards on the banks of the famous river, into a smart retreat. Six Senses is known for its sensational spas, and treatments here draw on local ingredients: lemons, oranges, olive oil, wine-grape pulp and pips. The new hotel even has two wine directors: Francisca van Zeller, whose family have been making wine here for more than 200 years, and Sandra Tavares da Silva, whose Wine & Soul vineyard is defining the new Douro generation (young vintners focusing on fine, unfortified reds). Together they have crafted a 700-bottle-strong list - about 85 per cent of which are ports or wines from the Douro - organised geographically up the river from the Atlantic to its source.