Month: October 2013

Protein transport and secretion is necessary for cellular function. Transport protein mediated a signal peptide located at amino terminal protein dad or hidden. The signal peptide consists of ten to twenty hydrophobic amino acids that target the nascent protein from ribosome to a particular membrane bound compartment such as the endoplasmic reticulum (ER). Protein target the ER to continue by way secretory or stay in any of the secretory organelles such as the ER, Golgi apparatus, or lysosomes. Proteins that transit through the secretory way be secreted into the extracellular space or left in the plasma membrane. Protein retained in the plasma membrane includes one or more transmembrane domains, each consisting of 20 hydrophobic amino acid residues. Secreted protein normally synthesized as inactive precursors because of the post-translation processing events during transit through the secretory way. Such events include glycosylation, proteolysis, and removal of the signal peptide with a signal peptidase. The other events that occur during the transport proteins include chaperone-dependent expression and folding of nascent proteins and protein interaction with a receptor or pore complex. Examples of secreted proteins with amino terminal signal peptide described below and include protein with an important role in cell-to-cell signaling. Such proteins include transmembrane receptor and cell surface markers, extracellular matrix molecules, cytokines, hormones, growth and diversity factor, enzyme, neuropeptides, vasomediators, cell surface markers, and antigen recognition molecules. (Reviewed in Alberts, B. et al. (1994) Molecular Biology of the Cell, garland Publishing, New York, NY, pp. 557-560, 582-592.)

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Mead Johnson Nutrition Company’s patent US 8557320 B2 deals with Nutritional composition having prebiotic.The present invention is directed to a novel method for increasing the production of acetate, reduced production of butyrate, increasing the population and species of beneficial bacteria and slowing the rate of fermentation of prebiotics within the gut a formula-fed children. method comprising administration of a therapeutically effective amount of PDX in children.

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The Citrix Systems, Inc. patent solves the following problem:

As the number of mobile employees, remote employees, guests and employees role-based employees increases, so the demand for computing systems that restrict the information contained in each type of employee, and shut personal data an employee from the work-related data. Many companies give their employees with laptops, remote access to the company Intranet, remote access to applications used by an employee, remote access to files on an employee, and access to remote desktop, virtual machine, or remote applications. In many instances, employees have access to company resources from any location, using any machine and / or network.

Citrix Systems, Inc.’s patent US 8560826 B2 deals with Secure virtualization environment bootable from an external media device.Methods and systems for creating a secure virtualization environment on a host of devices, without modification to the host device, secure virtualization environment bootable from an external media device. A host of computation load device and boots on a common operating system image stored on an external media device. A client agent stored on external media device and comply with the common operating system creates an adapted operating system image by copying the operating system of the device hosts Computing, removing all unnecessary files and data and storing the adapted operating system images on external media device. The host computing device provides a secure virtualized environment by pregnant adapted operating system images.

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The N.V. Nutricia patent solves the following problem:

The immune system has different possible ways to react to an antigen. A decisive step for the type of immune response is the stimulation of different T-cell subpopulations. So called Th1 cells typically produce cytokines, which stimulate a cellular immune response (IFN-, IL-12, IL-2). In contrast, Th2 cells typically produce IL-4, IL-5 and IL-0. These cytokines boost an IgE-mediated allergic reaction and inflammation and also thought to be involved in recruitment, growth, inequality, maintenance and survival of eosinophils (ie, leukocytes that accept an eosin stain), which can be leading to eosinophilia. Eosinophilia is a hallmark of many Th2 mediated diseases, such as asthma, allergies, and atopic dermatitis. Th1- and Th2-related cytokines act antagonistically and the Th1 / Th2 responses are under normal physiological circumstances in a well-controlled balance. Neither the Th1 nor the Th2 response prevails. If disbalance, the rule of one of Th1 or Th2 immune responses play a role in or is responsible for several pathological conditions.

N.V. Nutricia’s patent US 8557794 B2 deals with Immunemodulating oligosaccharides.The present invention relates to a method for enhancing the immune system and the treatment and / or prevention of related immune system disorder in a mammal, particularly newborns, said method comprising the administration of acid oligosaccharide and neutral oligosaccharide. Food composition suitable for use in the methods above is also given.

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Edward L. Schwarz’s patent US 8550713 B2 deals with Bag for handheld electronic device.A bag enclosing a handheld electronic device (HED) consists of a flexible sheet material such as a flexible or stretchy fabric. The material formed in a bag with a main body and a mouth. baba has a periphery smaller than the periphery of the main body. mouth become elastically stretch to allow the passage of HED. First and second loops that were included in the project from the bag next to the mouth to allow a user to support the bag with the thumb and fingers while inserting the HED. In one picture, a elastic structure covering the periphery of the mouth. The unstretched length of such an elastic structure can be adjusted to compensate for the volume of HED.

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Spleen Tyrosine Kinase (SYK) is a protein tyrosine kinase described as a key mediator of immunoreceptor signaling a host of inflammatory cells including mast cells, B-cells, macrophages and neutrophils. These immunoreceptors, including Fc receptor and the B-cell receptor, is important for allergic diseases, and antibody-mediated autoimmune diseases and thus pharmacologically interfering SYK conceivably treat these diseases.

Merck Sharp & Dohme Corp., , Merck Canada Inc.’s patent US 8551984 B2 deals with Aminopyrimidines as SYK inhibitors.The present invention provides new pyrimidine amines of formula (I), which is a strong inhibitor of spleen tyrosine kinase, and is useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD and rheumatoid arthritis.

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The Steven Todd Kron patent solves the following problem:

The things that influence fuel economy of semi-trucks, aerodynamics is the field that the greatest progress will be made soon. Two types of flying drag, friction drag and pressure drag, pressure drag has a particularly significant impact on heavy trucks, accounting for as much as 90% of the drag force. In a standard, unmodified truck and trailer, approximately a third of this pressure drag causes the vehicle undercarriage.

Steven Todd Kron’s patent US 8550541 B1 deals with Aerodynamic fittings for trailer crossmembers.The purpose of the device is to reduce the fuel consumption of heavy trucks by improving airflow along the underside of a trailer, using a series of rectangular panel to close the gap between trailer crossmembers and performance a continuous smooth surface. These panels are placed between adjacent crossmembers and strengthened their flanges with a large clamping mechanism. Each clamp consists of a U nut fitted to the edge of the panel and a half clip is locked down. With U nut clamping on the topside of the flange and half clip gripping the lower face of the crossmember, these clamps secure each panel in place. These fittings, requiring no changes to the crossmembers themselves, easily installed and easily removable.

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