Anyone else experienced this? This is on Synthetic Supplements' Forskolin-95. I did read other less reputable brands had this side effect. I'm on 100mg daily (x2 morning, x2 pre-workout), only been on it a week, and it's not pleasant, proper Hershey Squirts lol. Should I dial back dosage, or am I just a bad responder to this stuff? Anything else I could take to alleviate this problem?

I have rank gas when I take foreskolin but I've never been a fire hydrant of Hershey squirts

Well I read somewhere that due to the way Forskolin works, it reacts in such a way in the small intestine that means this side effect can be quite common (something to do with membrane permanent cAMP I think), so it's not a negative as much as a normal reaction, and you're lucky if you DON'T get it. Not sure if this is true or not though.

Well I read somewhere that due to the way Forskolin works, it reacts in such a way in the small intestine that means this side effect can be quite common (something to do with membrane permanent cAMP I think), so it's not a negative as much as a normal reaction, and you're lucky if you DON'T get it. Not sure if this is true or not though.

GI issues and Forsk have long been common, it isn't really a new supplement that no one has had trouble running. 95% is supposed to be nicer on the GI sides than the lower extract versions, but I have limited experience with taking a bunch of different extract amounts. Like anything else it's very user dependent.

Completely false. The higher % forskolin, the more likely GI effects will occur.

If a 95% forskolin extract does not cause increased motility/diarrhea, then it is bunk.

Hey I don't make the supplement nor the claims. As I said it's supposed (as in it's marketed) to be less than other extracts, but I put in my post I had limited experience with forsk and various extracts. I was only posting what is said about it, not my experience. I don't have enough personal experience with other extract percentages to say this is what I've noticed. AS 95% is pretty much all I've personally used.

We know exactly how forskolin produces diarrhea in the GI tract: it binds to adenylyl cyclase and dumps chloride ions into the lumen. The ions draw water producing an ismotic effect in the same way as Cholera.

Ironfist is quite right about the MOA by which forskolin can induce diarrhea. Anecdotally speaking, I think most would agree that an equivalent dose of forskolin, ingested as a low % extract vs a high % extract, produces different degrees of GI distress. This would most plausibly be due to other components found within the plant...the root is usually the specific site of extraction:

Ironfist is quite right about the MOA by which forskolin can induce diarrhea. Anecdotally speaking, I think most would agree that an equivalent dose of forskolin, ingested as a low % extract vs a high % extract, produces different degrees of GI distress. This would most plausibly be due to other components found within the plant...the root is usually the specific site of extraction:

Forksolin possesses the inherent capability to cause GI issues. The extract % is irrelevant here; the dose is what counts. However, exactly as the writeup says, people generally notice more GI issues with lower % extracts at equivalent forskolin doses. Since the only variation between a high and low % extract is the extra constituents of a lower % extract, the issue likely lies there (do some research on the compounds in the paper I posted).

Forksolin possesses the inherent capability to cause GI issues. The extract % is irrelevant here; the dose is what counts. However, exactly as the writeup says, people generally notice more GI issues with lower % extracts at equivalent forskolin doses. Since the only variation between a high and low % extract is the extra constituents of a lower % extract, the issue likely lies there (do some research on the compounds in the paper I posted).

Isn't IronFist saying exactly that? He was responding to my original post of the higher extract should see less GI distress.

Originally Posted by lronFist

Completely false. The higher % forskolin, the more likely GI effects will occur.

If a 95% forskolin extract does not cause increased motility/diarrhea, then it is bunk.

Isn't IronFist saying exactly that? He was responding to my original post of the higher extract should see less GI distress.

I know what he's trying to say, and that is that more forskolin = more GI issues. It is dose-dependent, not extract %-dependent, and I'm fairly certain he's just saying that a higher extract % will yield a higher dose of forskolin at an equivalent extract dose. In essence, he is saying that if you take equivalent doses of forskolin extracts, the one with the higher % forskolin will elicit more GI issues. Aka 500mg of 95% extract will cause more GI issues than 500mg of 20% extract. These are equivalent extract doses.

I am saying that based on the experiences of most forskolin users, 50mg of forskolin from 95% extract will yield less GI issues than 50mg of forskolin from a 20% extract. These are equivalent forskolin doses. I hope that's clear enough

Neither theory fits my own exp. ha When I use lower % I tend to have bad cramps the first and sometimes second days(stomach feels like its in knots),however with higher % I just have general diarrhea for several week - not terrible , but consistant loose stools for the run

Ironfist is quite right about the MOA by which forskolin can induce diarrhea. Anecdotally speaking, I think most would agree that an equivalent dose of forskolin, ingested as a low % extract vs a high % extract, produces different degrees of GI distress. This would most plausibly be due to other components found within the plant...the root is usually the specific site of extraction: