Hycamtin Capsules

"Tobacco control efforts are having a major impact on Americans' health, a new analysis of
lung-cancer data suggests. The rate of new lung cancer cases decreased among men and women in
the United States from 2005 to 2009, according to a re"...

DRUG DESCRIPTION

Topotecan hydrochloride is a semi-synthetic derivative of
camptothecin and is an anti-tumor drug with topoisomerase I-inhibitory
activity.

The chemical name for topotecan hydrochloride is
(S)-10-[(dimethylamino)methyl]-4-ethyl-4,9- dihydroxy-1#-pyrano[3',4': 6,7]
indolizino [1,2-6]quinoline-3,14-(4#,12#)-dione monohydrochloride. It has the
molecular formula C23H23N3O5•HCl
and a molecular weight of 457.9. It is soluble in water and melts with
decomposition at 213° to 218°C.

Topotecan hydrochloride has the following structural
formula:

HYCAMTIN capsules for oral use contain topotecan
hydrochloride, the content of which is expressed as topotecan free base. The
excipients are gelatin, glyceryl monostearate, hydrogenated vegetable oil, and
titanium dioxide. The capsules are imprinted with edible black ink. The 1-mg
capsules also contain red iron oxide.

What are the possible side effects of topotecan (Hycamtin)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.