Methods and results: The impact of recent and long-term fish consumption and EPA+DHA intake on (sudden) coronary death was investigated in the Zutphen Study, a cohort of 1373 men born between 1900 and 1920, and examined repeatedly between 1960 and 2000. Hazard ratios were obtained from time-dependent Cox regression models. The associations between long-term fish consumption, EPA+DHA intake, and (sudden) coronary death were stronger than those of recent consumption. Long-term fish consumption was inversely associated (borderline significant) with coronary heart disease (CHD) death; however, the strength of the association decreased from age 50 [HR: 0.32 (95% CI: 0.13–0.80)] until age 80 [HR: 1.34 (0.58–3.12)]. For men with a daily EPA+DHA intake from fish below 250 mg compared with no intake, CHD death risk was reduced to the same extent as for men with a daily intake above 250 mg (P-value for trend: 0.27). Moreover, long-term fatty-fish consumption lowered the risk of sudden coronary death [HR: 0.46 (0.27–0.78)].

Conclusion: The strength of the association between long-term fish consumption and CHD death decreased with increasing age. Fatty-fish consumption lowered sudden coronary death risk. There was no clear dose–response relationship between EPA+DHA intake and (sudden) coronary death.

Methods and results: The impact of recent and long-term fish consumption and EPA+DHA intake on (sudden) coronary death was investigated in the Zutphen Study, a cohort of 1373 men born between 1900 and 1920, and examined repeatedly between 1960 and 2000. Hazard ratios were obtained from time-dependent Cox regression models. The associations between long-term fish consumption, EPA+DHA intake, and (sudden) coronary death were stronger than those of recent consumption. Long-term fish consumption was inversely associated (borderline significant) with coronary heart disease (CHD) death; however, the strength of the association decreased from age 50 [HR: 0.32 (95% CI: 0.13–0.80)] until age 80 [HR: 1.34 (0.58–3.12)]. For men with a daily EPA+DHA intake from fish below 250 mg compared with no intake, CHD death risk was reduced to the same extent as for men with a daily intake above 250 mg (P-value for trend: 0.27). Moreover, long-term fatty-fish consumption lowered the risk of sudden coronary death [HR: 0.46 (0.27–0.78)]. 方法和结果：在Zutphen研究中，调查了近期和长期食用鱼类和摄入EPA+DHA对（突发性）冠心病的作用。调查了1373位出生自1900-1920年的男性，在1960-2000年间，对他们进行重复的体检。风险比从时间依赖的Cox回归模型中得出。长期使用鱼类，摄入EPA+DHA与（突发性）心脏病的相关性强于近期食用者。长期食用鱼类与冠心病（CHD）死亡负相关（基线时具有显著性）；但是，相关性的强度从50岁[HR: 0.32 (95% CI: 0.13–0.80)]开始下降，直到800岁降至最低值[HR: 1.34 (0.58–3.12)]。与未摄入者相比，每日摄入来自鱼类的EPA+DHA小于250mg的男性其CHD死亡风险下降程度和每日摄入250mg以上的男性是一样的。而且，长期食用高油脂鱼可降低突发性冠心病的风险。[HR: 0.46 (0.27–0.78)].

Conclusion: The strength of the association between long-term fish consumption and CHD death decreased with increasing age. Fatty-fish consumption lowered sudden coronary death risk. There was no clear dose–response relationship between EPA+DHA intake and (sudden) coronary death.结论： 长期使用鱼类和CHD死亡之间的关联强度随年龄的增长而下降。食用高油脂鱼类可降低突发性冠心病的风险。EPA+DHA摄入量和（突发性）冠心病死亡之间的关系没有明显的剂量依赖性。
长期食用鱼类及摄入n-3脂肪酸与（突发性）冠心病的关系： Zutphen研究