We believe that Dr. Brown has overinterpreted the purpose, methodology, and conclusions of our review. We evaluated the narrow question of whether comparative observational study data are sufficient to support (or refute) any putative associations between silicone gel implants and long-term adverse health outcomes. Future reviews would need to assess the evidence on associations between environmental silicone exposure and health outcomes. If we assess the totality of evidence on breast implants, the answer is, in brief, no—the examined evidence is inadequate to make conclusions about the long-term safety of silicone gel implants. This conclusion in no way supports any pro- or antisurgery, implant, or silicone agenda.