The occupational classification system used during Census 2000 consists of 509 specific occupational categories for employed people arranged into 23 major occupational groups. This classification was developed based on the Standard Occupational Classification (SOC) Manual: 2000, which includes a hierarchical structure showing 23 major occupational groups divided into 96 minor groups, 449 broad groups, and 821 detailed occupations. For Census 2000, tabulations with occupation as the primary characteristic present several levels of occupational detail.

Some occupation groups are related closely to certain industries. Operators of transportation equipment, farm operators and workers, and healthcare providers account for major portions of their respective industries of transportation, agriculture, and health care. However, the industry categories include people in other occupations. For example, people employed in agriculture include truck drivers and bookkeepers; people employed in the transportation industry include mechanics, freight handlers, and payroll clerks; and people employed in the health care industry include occupations such as security guard and secretary.

The data on sex, which was asked of all people, were derived from answers to long-form questionnaire Item 3 and short-form questionnaire Item 5. Individuals were asked to mark either "male" or "female" to indicate their sex. For most cases in which sex was not reported, it was determined from the persons given (i.e., first) name and household relationship. Otherwise, sex was imputed according to the relationship to the householder and the age of the person. (For more information on imputation, see "Accuracy of the Data.")

All civilians 16 years old and over who were either (1) "at work" - those who did any work at all during the reference week as paid employees, worked in their own business or profession, worked on their own farm, or worked 15 hours or more as unpaid workers on a family farm or in a family business; or (2) were "with a job but not at work" - those who did not work during the reference week, but who had jobs or businesses from which they were temporarily absent because of illness, bad weather, industrial dispute, vacation, or other personal reasons. Excluded from the employed are people whose only activity consisted of work around their own house (painting, repairing, or own home housework) or unpaid volunteer work for religious, charitable, and similar organizations. Also excluded are all institutionalized people and people on active duty in the United States Armed Forces.