FolateRSense™ targeted fluorescence imaging agent is highly specific and sensitive in its detection of Folate Receptor alpha (FRA) and can be used to closely monitor and quantitate tumor growth and metabolism. Over-expression of FRA protein is associated with tumor growth, and uptake of folic acid is a necessary part of tumor metabolism.

Brochure

Overexpression of Folate Receptor (FR) protein is associated with tumor growth, and uptake of folic acid is a necessary part of tumor metabolism. The FolateRSense imaging agent is highly specific and sensitive in its detection of FR and can be used to closely monitor and quantitate tumor growth and metabolism.

Citations Library

Poster

Folic acid (vitamin B9) is an essential nutrient required by eukaryotic cells for survival that is acquired and internalized via folate receptors (FR) on the cell surface. In particular, it is the highly metabolic cells that upregulate FR, and many different human tumor cells, including ovarian, breast, cervical, renal, colorectal and nasopharyngeal cancer cells show significant upregulation as compared to normal tissues. As such, folic acid has been successfully exploited as a cancer specific targeting moiety for the efficient delivery of chemotherapeutic agents, drug carriers, photosensitizers and diagnostic reporters. Critical to the success of such agents is the determination of the level of FR expression for a given tumor, since weak FR-expressing cancers will not respond well to folate-targeted therapies. There is therefore a need for specific and quantitative imaging agents