Scientists created uniformly sized PC-3 prostate cancer spheroids using a 3D culture plate. They demonstrated that cancer cells exhibited dormancy in a cell density-dependent manner not only in spheroids but also in 2D culture. [Sci Rep]
Full Article

The authors describe the current understanding of androgen synthesis and the evidence for its role in castration resistance, and examine the evidence supporting and or rebutting the relevance of each pathway to patients with prostate cancer. [Nat Rev Urol]
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Epic Sciences announced findings demonstrating a circulating tumor cell biomarker can identify patients with metastatic castrate resistant prostate cancer who are more likely to respond to treatment with a PARP inhibitor in combination with androgen receptor signaling inhibitors (ARSi) compared to those treated with ARSi alone. [Press release from Epic Sciences discussing research presented at the 2016 American Society of Clinical Oncology (ASCO) Annual Meeting, Chicago]
Press Release

Researchers have discovered that a marker found on aggressive prostate cancer cells could also be used as a way to guide treatments to the cancer. The researchers attached the drug saporin to an antibody targeted against NAALADL2 to destroy prostate cancer cells in the lab. [Press release from Cancer Research UK discussing research presented at the Cancer Research Institute (NCRI) Cancer Conference, Liverpool]
Press Release

University of California, Irvine (UCI) health policy researchers have been awarded $1.2 million by the California Initiative to Advance Precision Medicine to develop more effective ways for prostate cancer patients and their physicians to customize treatment. [University of California, Irvine]
Press Release

George Washington University (GW) researchers received a $2.2 million grant from the National Cancer Institute to uncover why certain cancer types increase whereas others are unchanged or even decrease in those with HIV infection. [George Washington University]
Press Release

Brazil’s science budget has shrunk by more than 40% in the past three years. But researchers are now trying to escape an even worse crisis: federal science spending could be frozen at its current low level for the next two decades, under a constitutional amendment to cap public spending to only inflation-level rises. [Nature News]
Editorial

Ever since June’s Brexit referendum, scientists have fretted about the uncertainty caused for non-British EU nationals, who have been left unsure what their employment rights may be in a few years’ time. There are around 31,000 such researchers in the United Kingdom, according to a Royal Society estimate, and they make up about 15% of UK universities’ academic staff. [Nature News]
Editorial

Two major airlines have stopped transporting laboratory animals from mainland Spain to the Canary Islands, an archipelago in the Atlantic Ocean. Their move has put research projects on the islands on hold and has left scientists and politicians scrambling for solutions. The ban is particularly problematic for researchers who need transgenic mice, which are often ordered from specialized labs. [Science Insider]
Editorial

The European Medicines Agency (EMA), in cooperation with the European Commission and the EU member states, proposed revisions to its 2007 guideline on first-in-human clinical trials as part of an effort to further improve the safety of participants as trial protocols become increasingly complex. [Regulatory Affairs Professionals Society]
Editorial | Guideline

A science star–studded group that including two former directors of the National Institutes of Health (NIH) in Bethesda, Maryland, released a set of recommendations aimed at making NIH run better and offered advice on choosing an NIH director—ideally within Trump’s first 100 days in office. [Science Insider]
Editorial