Armstrong admitted off the bat that he had doped during all seven of his Tour de France victories, and Twitter users let loose on the cyclist (and Oprah) for the following 90 minutes.

The second part of the interview is set to air Friday, but we've collected the best reaction to hit the web in 140-character bursts.

Check out the highlights here:

Cyclist and former Armstrong teammate Jonathan Vaughters @Vaughters: "A good first step. I need to sleep."

Author of Lance Armstrong book "Seven Deadly Sins" David Walsh @DavidWalshST: "First reaction is Oprah began the interview brilliantly with her series of 'yes or no' questions. It felt good to hear him admit to doping."

U.S. Women's Soccer Team forward Alex Morgan @alexmorgan13: "Just wasted an hour and half of my life doing what probably half of Americans just did #annoyed"

IndyCar driver Rahal Graham @GrahamRahal: "Watching Lance's interview. Man, like so many this guy was a hero. Guess I can take his signed TDF worn jersey off my wall."

Television host Piers Morgan @piersmorgan: "What a snivelling, lying, cheating little wretch @lancearmstrong revealed himself to be tonight. I hope he now just disappears. #LiveWrong"

Sports On Earth writer Joe Posnanski: "Lance: 'So, be honest with me, how am I doing?' Twitter: 'Um, well, I'd have to say not super great.'"

Comedian Rob Delaney @robdelaney: "Perhaps most devastating is that Lance Armstrong's subscription to 'O' will be revoked."

Track runner, Olympian Nick Symmonds @NickSymmonds: "Yeah that's probably enough of Lance for one night. Some of us will actually get up early and put in the hard, honest work. #CleanSport"

Los Angeles Daily News columnist Jill Painter @jillpainter: "Been watching the @lancearmstrong interview with #oprah, and in the first 17 minutes, he said sorry once, and it was in passing. #hardtosay"

Filmmaker/actor/author Albert Brooks @albertbrooks: "When I rode tandem with Lance Armstrong I was on nothing."