STAT5 alpha/beta Polyclonal Antibody

STAT5 alpha/beta Antibody (PA5-17355)

Western blot analysis of Stat5 in extracts from HeLa and K562 cells using Stat5 polyclonal antibody (Product # PA5-17355).

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Product Details

Bioinformatics

Documents

Synthetic peptide corresponding to an amino-terminal region within Stat5

Conjugate

Unconjugated

Form

Liquid

Purification

Antigen affinity chromatography

Storage buffer

0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/ml BSA, 50% glycerol

Contains

no preservative

Storage Conditions

-20°C

Tested Applications

Dilution *

ChIP assay (ChIP)

1:25

Immunoprecipitation (IP)

1:25

Western Blot (WB)

1:1000

* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the
product for use in their own experiment using appropriate negative and positive controls.

Product Specific Information

It is not recommended to aliquot this antibody.

Background/Target Information

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for the tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.