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"Presume that a major hurricane is going to hit right smack dab in the middle of South Carolina."

McMaster said he had asked President Donald Trump to declare a federal emergency in South Carolina in anticipation of the storm's arrival.

Residents as far north as Virginia were warned that Florence posed an increasing risk of generating a life-threatening coastal storm surge, as well as flooding from heavy rainfall should the slow-moving storm stall over the southeast.

Hurricane Florence as seen from the International Space Station (Image: GETTY)

North Carolina Governor Roy Cooper also urged his state's residents to get ready, noting the storm already was generating swelling waves and dangerous currents along the coast.

"Everyone in North Carolina needs to keep a close eye on Florence and take steps now to get ready for impacts later this week," Cooper said in a statement on Sunday.

The governors of Virginia, North Carolina and South Carolina have all declared states of emergency.