Awareness is growing that osteoporosis, long considered a women's health issue, significantly affects men. Gaining a fuller understanding of the epidemiology, pathogenesis, diagnosis, and treatment of osteoporosis in men and how it relates to comorbidities, such as hypogonadism, is increasingly important. It is imperative for clinicians to recognize male osteoporosis as a serious health concern and develop a protocol for how to best manage it. This issue examines the relationship between bone health and hypogonadism. The feature article by Adrian S. Dobs, MD, MHS, describes our current understanding of osteoporosis and examines how treating hypogonadism may improve both conditions and lead to better overall health. In the interview, John E. Morley, MB, BCh, explains how he manages concomitant osteoporosis and hypogonadism for his patients.