Applications

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application

Abreviews

Notes

ELISA

Use at an assay dependent dilution.

RIA

Use at an assay dependent dilution.

IP

Use at an assay dependent dilution.

Target

Function

Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3.

Involvement in disease

Atrial standstill 2Atrial fibrillation, familial, 6

Sequence similarities

Belongs to the natriuretic peptide family.

Post-translationalmodifications

Cleaved by CORIN upon secretion to produce the functional hormone.Atrial natriuretic factor: Cleaved by MME. The cleavage initiates degradation of the factor and thereby regulate its activity.