The 2nd CBSS Baltic Sea Science Day was an integral part of the 5th Baltic University Programme Rectors´ Conference. The overall gathering demonstrated that sustainability and prosperity of the Baltic Sea Region is being developed on the basis of an inclusive dialogue on research-intensive sectors. Baltic University Programme is committed to align such efforts with UN Sustainable Development Goals. In this regard the CBSS Baltic 2030 Action Plan comes to the fore as the key reference point in the Baltic Sea Region setting. Baltic Science Network findings testify that functional proximity requires extensive discussions among research experts on their niche profiles and potential complementarities. Be it a pocket of excellence in blue growth, circular economy, zero waste or sustainable energy, Baltic TRAM open call highlights the necessity to exploit the full transnational potential of such a hub, which requires macroregional access and well-connected knowledge dissemination points.