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Madrid on a Sunday?..Wineries in Seville and Barcelona ; Nerja?

22 days in Spain - first 3. In Madrid - but we heard that most tourist places are closed both Sunday and Monday . We are hoping to visit Toledo and Segovia before heading to Seville . Please tell us what to see first. We are also going to be in Seville for three days and Barcelona for five so we are looking for culture and wineries in both places. As an aside we will be in Nerja too any sites to visit there.