Target Details BID

Bid is a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2. Bid is a member of the BCL-2 family of cell death regulators. It is a mediator of mitochondrial damage induced by caspase-8 (CASP8), CASP8 cleaves this encoded protein, and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release.Synonyms: BH3-interacting domain death agonist, p22 BID

Mandal, Crusio, Meng, Liu, Kinsella, Clark, Takeuchi, Aifantis: "Regulation of lymphocyte progenitor survival by the proapoptotic activities of Bim and Bid." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 52, pp. 20840-5, 2008