RT Journal
A1 Teitelbaum JE, Bird B, Weiss A, Gould L
T1 LOw-dose hydrocortisone for chronic fatigue syndrome
JF JAMA
JO JAMA
YR 1999
FD May 26
VO 281
IS 20
SP 1887
OP 1889
DO 10-1001/pubs.JAMA-ISSN-0098-7484-281-20-jbk0526
UL http://dx.doi.org/10-1001/pubs.JAMA-ISSN-0098-7484-281-20-jbk0526
AB
Our previously published pilot study2 and the work of
Jefferies3,4 suggests that using low-dose hydrocortisone (4
mg of hydrocortisone ≈ 1 mg of prednisone) in CFS at dosages of 7.5
to 20 mg/d is safe and effective. These low dosages have not caused the
adrenal suppression3,4 seen with the higher dosages (25-35
mg/d) used by McKenzie et al. They are also less likely to aggravate
the already severe disruption of deep sleep present in CFS patients, as
was seen in the study by McKenzie et al (P=.02
vs placebo).