There's really a big difference b/w your normal knives, versus a knife that favors the left or right hand. I generally find that it helps the handle feel more balanced in your hand. However, I have also found those same knives to lack the same overall blanace as a high quality neutral-handed knife. It comes down to how the knife feels in your hand., and the quality of the blade. If you have found those 2 things, then you have found yourself a good knife.