Viewscream 2nd Edition Kickstarter – unique because it’s a LARP using a platform like Google Hangouts. Three to five players assume the roles of desperate people trapped in a world of high-tech horror: crew members going insane aboard a damaged starship; scientists in research labs, hunted by their own creations; or futuristic data-thieves on the run from soulless security drones. https://www.kickstarter.com/projects/rafaelchandler/viewscream-2nd-edition

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You can leave the out right horror out of any of the Gumshoe horror games. I suggest grabbing Night’s Black Agent’s conspiramid, and using Fear itself, Esoterrorists, or Night’s Black Agents rules without the supernatural parts depending on the level of competence you want the players to have (Fear itself for normals, Esoterrorists for competent, NBA for special forces)
Also if you look at real world history, the last two or 3 hunddred years are full of crazy adventures and bizzare and dangerous cults, all without any real supernatural stuff. A group of crowleyites who are willing to kidnap and drug or murder their opposition aren;’t less crazy or dangerous than a cult with actual magic.

Leverage is another game that lets you do all of that stuff. In a leverage campaign with the party fighting mobsters, most episodes aren’t about the mob, but they all help build up the ability for a group of 5 people to face off against organized crime that will just shoot them in the head if they go head on.