Frequent overexpression of SMYD2 mRNA and protein was observed in KYSE150 cells with remarkable amplification at 1q32-q41.1 and other ESCC cell lines (11/43 lines, 25.6%). Overexpression of SMYD2 protein was frequently detected in primary tumor samples of ESCC (117/153 cases, 76.5%) as well and significantly correlated with gender, venous invasion, the pT category in the tumor-lymph node-metastasis classification and status of recurrence. Patients with SMYD2-overexpressing tumors had a worse overall rate of survival than those with non-expressing tumors. Knockdown of SMYD2 expression inhibited and ectopic overexpression of SMYD2 promoted the proliferation of ESCC cells in a TP53 mutation-independent but SMYD2 expression dependent manner (Komatsu et al., 2009).

Entity

Thyroid carcinoma and benign thyroid nodule

Note

Using differential display-polymerase chain reaction method, the gene expression differences between benign thyroid nodules (BTNs) and follicular and classic variants of papillary thyroid carcinoma (PTC) were evaluated in a group of 42 patients (15 BTNs, 14 follicular variant of PTC and 13 classic variant of PTC). SMYD2 had lower expression in both carcinoma groups than in BTNs (Igci et al., 2011).

Expression of a group of three genes (MTSS1, RPL37, and SMYD2) evaluated by real-time PCR was shown to be a potential candidate to predict response to neoadjuvant chemotherapy (4 cycles of doxorubicin and cyclophosphamide) in breast cancer patients (Barros Filho et al., 2010).

Bibliography

The tale of two domains: proteomics and genomics analysis of SMYD2, a new histone methyltransferase.