Holden is a town in Worcester County, Massachusetts, United States. The town was founded in 1741, and the Town Square was donated by John Hancock, former Governor of Massachusetts.

The population was 17,346 at the 2010 census.

According to the United States Census Bureau, the town has a total area of 36.2 square miles (94 km2), of which 35.0 square miles (91 km2) is land and 1.2 square miles (3.1 km2), or 3.40%, is water. The landscape is dominated by hills and rivers, including the Quinapoxet.

Holden is bounded on the west by Rutland, on the northwest by Princeton, on the east by Sterling and West Boylston, on the southeast by Worcester, and on the southwest by Paxton.

As of the census of 2000, there were 15,621 people, 5,715 households, and 4,423 families residing in the town. The population density was 446.4 inhabitants per square mile (172.4 /km2). There were 5,827 housing units at an average density of 166.5 per square mile (64.3 /km2). The racial makeup of the town was 97.39% White, 0.49% African American, 0.10% Native American, 0.99% Asian, 0.01% Pacific Islander, 0.24% from other races, and 0.79% from two or more races. Hispanic or Latino of any race were 0.96% of the population.

There were 5,715 households out of which 37.4% had children under the age of 18 living with them, 67.8% were married couples living together, 7.2% had a female householder with no husband present, and 22.6% were non-families. 19.5% of all households were made up of individuals and 9.7% had someone living alone who was 65 years of age or older. The average household size was 2.71 and the average family size was 3.13.

In the town the population was spread out with 27.0% under the age of 18, 5.1% from 18 to 24, 26.9% from 25 to 44, 26.7% from 45 to 64, and 14.2% who were 65 years of age or older. The median age was 40 years. For every 100 females there were 93.4 males. For every 100 females age 18 and over, there were 89.7 males.

The median income for a household in the town was $64,297, and the median income for a family was $73,614. Males had a median income of $52,203 versus $36,194 for females. The per capita income for the town was $27,971. About 2.0% of families and 3.1% of the population were below the poverty line, including 3.3% of those under age 18 and 4.8% of those age 65 or over.