OBJECTIVES: To evaluate the effect of bio-oxidative ozone application at the points of greatest pain in patients with chronic masticatory muscle pain.

METHODS: A total number of 40 (40 women, with a mean age of 31.7) were selected after the diagnosis of myofacial pain dysfunction syndrome according to the Research Diagnostic Criteria for Temporomandibular Disorder (RDC/TMD). The patients were randomly divided into two groups; patients received the ozone therapy at the point of greatest pain, ozone group (n = 20); patients received the sham ozone therapy at the point of greatest pain, placebo group (n = 20). Ozone and placebo were applied three times per week, for a total of 6 sessions. Mandibular movements were examined, masticator muscles tenderness were assessed and Pressure Pain Threshold (PPT) values were obtained. Subjective pain levels were evaluated using Visual Analogue Scale (VAS). These assessments were performed at baseline, 1 month and 3 months.

CONCLUSION: Although ozone therapy can be accepted as an alternative treatment modality in the management of masticatory muscle pain, sham ozone therapy (placebo) showed significant improvements in the tested parameters. This article is protected by copyright. All rights reserved.