http://www.derekclarke.com/http://www.derekclarke.com/
Welcome to http://www.derekclarke.com/ feed pageen-usinfo@derekclarke.comCopyright 2019Healthcare Products Onlinehttp://www.derekclarke.com/services/healthcare-products-online/3
http://www.derekclarke.com/services/healthcare-products-online/3<p>Derek Clarke provides for all your mobility/homecare needs from walking sticks through to wheelchairs, walkers and beyond.</p>
<p><br />
We offer competitive low-priced medical products in the UK as well as to other countries. Our healthcare products are also available online. Our dedicated in-house team can assist you on product selection across our wide range, whether it be bedding/continence products or portable nebulisers. In short, we can provide anything required to improve the quality of your health at home.</p>Dispensing Serviceshttp://www.derekclarke.com/services/dispensing-services/4
http://www.derekclarke.com/services/dispensing-services/4<p>Derek Clarke Pharmacy dispenses both NHS and private prescriptions, using an advanced database that records all dispensed items. For each new medicine you have been prescribed, we will know instantly whether it is compatible with those you may already be taking.</p>
<p><br />
Our labels will automatically provide warnings about alcohol, drowsiness, operating machinery and driving. We also ensure that we are fully stocked and have up-to-date information on the latest medicines available.&nbsp;</p>Customer Servicehttp://www.derekclarke.com/services/customer-service/5
http://www.derekclarke.com/services/customer-service/5<p>At Derek Clarke Pharmacy we aim to give the best possible service and quality assured medical products.</p>
<p><br />
Please speak to the pharmacists in charge if you have any further questions or would like further information about our services and we will answer them as soon as possible. Your queries will be handled in line with the NHS national procedure. If we cannot resolve the problem or you do not want to raise it directly with us, you may contact your local health authority.</p>Pharmaceutical Home Deliveryhttp://www.derekclarke.com/services/pharmaceutical-home-delivery/6
http://www.derekclarke.com/services/pharmaceutical-home-delivery/6<p>Derek Clarke offers a prescription collection and delivery service. With our Home Delivery program, we make sure that the clients receive their deliveries on time. For further information please call us or speak to one of our Pharmacists.</p>
<p>&nbsp;</p>
<p><a href="mailto:Paresh@derekclarke.com">Paresh@derekclarke.com</a><br />
+44 (0) 208 952 2061</p>Emergency Dispensinghttp://www.derekclarke.com/services/emergency-dispensing/7
http://www.derekclarke.com/services/emergency-dispensing/7<p>Derek Clarke Pharmacy is instrumental in providing you with <a href="http://www.derekclarke.com/services_details-medical_supplies_online-24.htm">Online Medical Supplies</a> in UK. If you require Emergency Medicines when we are not on duty, please contact your local NHS Direct 0845 4647. Our <strong>Emergency Medical Dispensing</strong> is a sigh of relief for all the crucial conditions.</p>Unwanted Medicineshttp://www.derekclarke.com/services/unwanted-medicines/8
http://www.derekclarke.com/services/unwanted-medicines/8<p>You should always complete the full course of any medicines prescribed to you. If you still have any medicines from old prescriptions DO NOT KEEP THEM as they may no longer be safe to take.</p>
<p><br />
Please bring them in to us and we can dispose of your unwanted medicines in an appropriate and environmentally safe manner.</p>Repeat Prescriptionshttp://www.derekclarke.com/services/repeat-prescriptions/9
http://www.derekclarke.com/services/repeat-prescriptions/9<p>Derek Clarke Pharmacy makes it easier for you to have your prescriptions and medication as and when you need them.</p>
<p><br />
We can collect prescriptions on your behalf from the following surgeries:</p>
<p>&nbsp;</p>
<ul>
<li>Lane End Medical Group, 2 Penshurst Garden, Edgware</li>
<li>Penshurst Doctors Surgery, 39 Penshurst Gardens, Edgware</li>
<li>Dr Hommel &amp; Partners, 11 Bacon Lane, Edgware</li>
<li>Oak Lodge Medical Centre, 234 Burnt Oak Broadway, Edgware</li>
<li>Jai Medical Centre, 114 Edgwarebury Lane, Edgware</li>
<li>The Surgery, 3 Sefton Avenue, Mill Hill</li>
<li>Stanmore Medical Centre, 85 Crowshott Avenue, Stanmore</li>
<li>Watling Medical Centre, 42 London Road, Stanmore</li>
<li>Woodcroft Medical Centre, Gervase Road, Burnt Oak, Edgware</li>
<li>Watling Medical Centre, 108 Watling Avenue, Burnt Oak</li>
<li>Millway Medical Practice, Hartley Avenue, Mill Hill</li>
<li>The Phoenix Surgery, Clare House, Manor Park Crescent, Edgware</li>
<li>Park View Surgery, Cresingham Road, Edgware.</li>
</ul>
<p><br />
If you are unable to collect your prescription from your doctor due to work commitments, we may also be able to help.</p>
<p><br />
Please contact the duty pharmacist for details on the collection of prescriptions from other surgeries.</p>
<p><br />
<a href="mailto:Paresh@derekclarke.com">Paresh@derekclarke.com</a><br />
+44 (0) 208 952 2061</p>UK & EU Prescription Servicehttp://www.derekclarke.com/services/uk-eu-prescription-service/16
http://www.derekclarke.com/services/uk-eu-prescription-service/16The Online Medical Consultations of &lt;b&gt;&lt;a href=&quot;http://www.derekclarke.com/contactus.html&quot;&gt;Derek Clarke Pharmacy &lt;/a&gt;&lt;/b&gt; are trusted upon all over the world. Get effective health benefits with our reliable Medical Prescriptions. We specialise in offering our services to not only national but also international patients/clients. All that we need prior to shipment is a faxed, emailed or by filling in the enquiry form within your login portal, a copy of the prescription with the delivery address (if the prescription is not going to your hospital) and credit card information; once this has all been received, the package(s) will be dispatched without delay. Delivery addresses in the third countries can also be targeted, should your patients be in the process of moving to or from another overseas location.Medication Verificationhttp://www.derekclarke.com/services/medication-verification/17
http://www.derekclarke.com/services/medication-verification/17<p>Counterfeit medicines are a real concern that can greatly endanger human health. At Derek Clarke, we take counterfeit drugs extremely seriously. On the extremely rare occasion that we may have been sold a counterfeit drug, we will take all necessary means to safeguard patients&rsquo; health and alert the relevant health authorities.</p>Generic Drug Exportershttp://www.derekclarke.com/services/generic-drug-exporters/33
http://www.derekclarke.com/services/generic-drug-exporters/33<p>Derek Clarke is one of the UK&rsquo;s leading generic drug exporters. As a generic drug exporter, we specialise in:</p>
<p>&nbsp;</p>
<ul>
<li>The global supply of orphan drugs</li>
<li>Provision of drugs in short supply</li>
<li>Innovator samples</li>
<li>Generic drug samples for clinic trials or research</li>
</ul>
<p><br />
We offer a wide range of generic as well as branded drugs, over-the-counter products and other pharmacy goods to healthcare professionals outside the UK across a range of therapeutic categories.</p>
<p><br />
At Derek Clarke, we ensure our generic drug exports are of the highest quality, manufactured to the same standards of safety, quality and efficacy as original branded drugs, and demonstrating bioequivalence to the original product.</p>
<p><br />
In addition, we have an extensive inventory of branded drugs including antiviral medicine exports, Tysabri, Tracleer, Tecfidera, Opdivo, PLEGRIDY Injection, Oncaspar, Jafaki, Keytruda Injection, Promacta tablet, Imbruvica capsules and Avonex injection.</p>
<p><br />
With more than 30 years of experience as a generic drug exporter we have developed a strong global network of retail pharmacies. Through these relationships we can obtain and export most specialties - often unavailable through regular sources - quickly and efficiently. These pharmacies are based in London, Brussels, Madrid, New York, Paris, Singapore and Sydney.</p>
<p><br />
We export across Europe, the Middle East and Africa. With our unparalleled customer service and extensive stock of both generic and branded products we are confident that we will be able to fulfil your requirements. For more details about our generic drug exports and other services, please contact us on +44 (0) 208 952 2061.&nbsp;</p>The Flying Pharmacyhttp://www.derekclarke.com/services/the-flying-pharmacy/22
http://www.derekclarke.com/services/the-flying-pharmacy/22<p>As a long-established UK-registered pharmacy, Derek Clarke prides itself in delivering genuine medicines to you, no matter where you may be in the world.</p>
<p>&nbsp;</p>
<p>One of the greatest concerns for international travellers and tourists is being stranded a long way from home without medical help. Since its formation over 20 years ago the Flying Pharmacy service has proved invaluable to a great number of British, American and other nationals working or on holiday overseas. We send express, overseas deliveries of urgently needed, high quality medicines that are often unavailable in a foreign country.</p>
<p>&nbsp;</p>
<p>Whether you find yourself working abroad, or are simply on vacation, you and your loved ones can relax in the knowledge that the Flying Pharmacy is right around the corner and ready to help.</p>
<p>&nbsp;</p>
<p>Our medicines and medical products are manufactured in Western Europe by the world&rsquo;s leading pharmaceutical companies and are delivered anywhere and everywhere by express shippers within five working days.</p>
<p>&nbsp;</p>
<p>We complete local customs&rsquo; clearance on your behalf, as long as the medicine you have been prescribed is:</p>
<p>&nbsp;</p>
<ul>
<li>Not a prohibited or restricted substance</li>
<li>Covered by a valid prescription</li>
<li>For your own personal use or that of a dependant</li>
<li>Not for delivery within the UK</li>
</ul>
<p><br />
We can ship up to three months' supply of the medication within a matter of days. We simply require:</p>
<p>&nbsp;</p>
<ul>
<li>A faxed or emailed copy of your prescription</li>
</ul>
<p><br />
If this is not immediately available, kindly provide us with the names and quantities of the medicines you require and the name and address of your doctor or practitioner</p>
<p>&nbsp;</p>
<ul>
<li>We will then fax or email you a personalised order form including the price of your prescription</li>
<li>Please include your name, address and credit card information and fax or email us back a completed order-form</li>
</ul>
<p><br />
Once payment has been processed your medicine will be dispatched by express door-to-door courier.</p>
<p>Please note we CANNOT ship any medication without a clear copy of a valid prescription.</p>
<p>Special Items</p>
<p>PROGESTERONE IN OIL 50mg/1ml<br />
IN A HYPO-ALLERGENIC BASE<br />
US$ 150.00 per 10 x 1ml</p>
<p>Products Available</p>
<p>&nbsp;</p>
<p>PERGONAL 75iu<br />
BRAVELLE<br />
ANTAGON 0.25mg<br />
GONAL-F PEN 450IU<br />
GONAL-F PEN 900IU<br />
GONAL-F 75iu<br />
SYNAREL 60 dose<br />
MENOPUR 75iu Pack of 10</p>
<p>&nbsp;</p>
<p>Please note that trade names can vary from market to market; for more precise specifications, please contact our pharmacy team.</p>
<p><a href="http://derekclarke.com/pages/contactus">http://derekclarke.com/pages/contactus</a></p>
<p><br />
Contact details</p>
<p>Our skilled team of pharmacy professionals can be contacted 24/7 on:</p>
<p>+ 44 20 8952 2061, + 44 20 8951 4546</p>
<p>Fax: +44 20 8952 2995</p>
<p>&nbsp;</p>
<p>email: <a href="mailto:dcpharma@btconnect.com">dcpharma@btconnect.com</a></p>
<p>&nbsp;</p>
<p>Instant Contact Quick Query:<br />
<a href="http://derekclarke.com/pages/contactus">http://derekclarke.com/pages/contactus</a></p>Antiviral Medicine Exporterhttp://www.derekclarke.com/services/antiviral-medicine-exporter/34
http://www.derekclarke.com/services/antiviral-medicine-exporter/34<p>Derek Clarke is a long-established UK antiviral medicine exporter. With more than 30 years of experience as a generic and branded drug exporter, we have developed a large supply of antiviral medicines against a range of indications including pneumonia, influenza etc .</p>
<p><br />
Through our global network of retail pharmacies, we are able to obtain and export most antiviral medicines and vaccines&nbsp; - often unavailable through regular sources - quickly and efficiently. These pharmacies are based in London, Brussels, Madrid, New York, Paris, Singapore and Sydney.</p>
<p><br />
We export across Europe, the Middle East and Africa. With our unparalleled customer service and extensive stock of products we are committed to fulfilling your requirements, no matter how large or small or how specific they may be. For more details about our antiviral medicine exports and our full list of products, please contact us on xxxx.&nbsp;<br />
&nbsp;</p>British Expats WorldWide!http://www.derekclarke.com/services/british-expats-worldwide/23
http://www.derekclarke.com/services/british-expats-worldwide/23<p>Derek Clarke Pharmacy provides British expats around the world with specialist vaccines and medication quickly and efficiently. We understand how difficult it can be living or working in a foreign country and are on hand to cater for your needs.</p>
<p><br />
We work in conjunction with expat hospitals and surgeries, making us a universal pharmacy to help expats whenever they need us.</p>
<p><br />
Our expat services include:</p>
<p>&nbsp;</p>
<ul>
<li>Specialist healthcare</li>
<li>Specialist vaccines and medication</li>
<li>Prescriptions</li>
<li>Emergency medication and vaccines</li>
<li>Online dispensing services</li>
</ul>
<p><br />
We deliver around the world within five days. Please contact us to see how we can help.</p>
<p><br />
<a href="mailto:Paresh@derekclarke.com">Paresh@derekclarke.com</a></p>
<p>+44 (0) 208 952 2061</p>Medical Supplies Onlinehttp://www.derekclarke.com/services/medical-supplies-online/24
http://www.derekclarke.com/services/medical-supplies-online/24<p><a href="http://www.derekclarke.com/">Derek Clarke pharmacy</a> are suppliers of medicine and already are supplying Cadila Zydus, Wockhardt with all their batch control innovator samples( Clinical Trials )for their R&amp;D and bio-study activities, we are capable of sending large scale samples temperature controlled across the world, our temperature controlled system is traceable and lets us know if the temperature has breach its limits, everywhere the package moves. Apart from this, we also specialise in offering Clinical Trials Supplies and Innovator Samples.<br />
<br />
We are a registered pharmacy and also have WLD license (copy attached )so we are able to obtain most of the medicine that is registered in UK &amp; EU &amp; rest of the world. Email us or call us direct !</p>Innovator Samples Supplyhttp://www.derekclarke.com/services/innovator-samples-supply/25
http://www.derekclarke.com/services/innovator-samples-supply/25<p>We source and supply branded products across the EU for clinical use. These products are imported into the UK, from where we regularly pack and send them around the world.</p>
<p>&nbsp;</p>
<p>Products can be sourced from single or multiple batches to meet national requirements:</p>
<p>&nbsp;</p>
<p>ITALY: Product X &ndash; 20 packs from batch 1, 15 packs from batch 2, 12 packs from batch 3</p>
<p>&nbsp;</p>
<p>SPAIN: Product Y &ndash; 30 packs from 1 batch</p>
<p>&nbsp;</p>
<p>UK: Product Z &ndash; 10 packs from batch 1, 10 packs from batch 2, 10 packs from batch 3</p>
<p>&nbsp;</p>
<p>We use dedicated transport companies specialising in cold, ambient and everyday storage and specific delivery requirements.</p>
<p>&nbsp;</p>
<p>Our team regularly updates and advises on product shortages or manufacturer delays, enabling clients to plan and monitor their studies accordingly.</p>Emergency Response Center, Assistance Serviceshttp://www.derekclarke.com/services/emergency-response-center-assistance-services/28
http://www.derekclarke.com/services/emergency-response-center-assistance-services/28<p><a href="http://www.derekclarke.com/images/3497313Jan2014080149Derek_Clarke.pdf" target="_blank"><span style="color:rgb(0,176,240);"><strong>Emergency Response Center, Assistance Services</strong></span><br />
Ring <span style="color:#ff0000"><strong>+44 (0) 2089522061</strong></span> ask for the Pharmacist on Duty.<br />
Try out our new <strong><span style="color:#3366ff"><u>Private Prescription Service.</u></span></strong></a></p>London Travel Clinichttp://www.derekclarke.com/services/london-travel-clinic/32
http://www.derekclarke.com/services/london-travel-clinic/32<p>Our&nbsp;team at Derek Clarke Pharmacy provide a comprehensive range of travel healthcare advice, vaccines and anti-malarials&nbsp;to travellers,&nbsp;families and corporates. We pride ourselves on our deep, specialist knowledge and the quality of the care that we provide to each and every customer.</p>
<p>&nbsp;</p>
<p>Our London Travel Clinic now operate within north west London and have a&nbsp;well-equipped clinic for London, and employs a professional and experienced team of workers. At out London Travel Clinic we stock a comprehensive range of vaccines, anti-malarials and travel health accessories, and provide the latest healthcare advice to help you stay fit and healthy when travelling overseas.</p>
<p>&nbsp;</p>
<p>Our skilled team are highly trained and well travelled, and they use this insight to help better prepare and protect every individual we see wherever in the world they jet off.</p>
<p>&nbsp;</p>
<p>Yellow Fever<br />
Rabies<br />
Hepatitis A<br />
Hepatitis B<br />
Typhoid<br />
Diphtheria/tetanus and polio<br />
Malaria tablets</p>
<p>&nbsp;</p>
<p>Please download the&nbsp;<a href="http://derekclarke.com/uploaded_files/userfiles/files/DC World Travel Clinic Leaflet A5.pdf"><span style="color:rgb(255, 0, 0)">BROCHURE</span></a> for further information</p>
<p>&nbsp;</p>Generic Medicine Exportershttp://www.derekclarke.com/services/generic-medicine-exporters/35
http://www.derekclarke.com/services/generic-medicine-exporters/35<p>Derek Clarke is one of the UK&rsquo;s leading generic medicine exporters. As a generic medicine exporter, we specialise in:</p>
<p>&nbsp;</p>
<ul>
<li>The global supply of orphan drugs</li>
<li>Provision of drugs in short supply</li>
<li>Innovator samples</li>
<li>Generic drug samples for clinic trials or research&nbsp;</li>
</ul>
<p><br />
We offer a wide range of generic as well as branded medicines, over-the-counter products and other pharmacy goods to healthcare professionals outside the UK across a range of therapeutic categories.</p>
<p><br />
At Derek Clarke, we ensure our generic medicine exports are of the highest quality, manufactured to the same standards of safety, quality and efficacy as original branded drugs, and demonstrating bioequivalence to the original product.</p>
<p><br />
In addition, we have an extensive inventory of branded medicines including antiviral medicine exports, Tysabri, Tracleer, Tecfidera, Opdivo, PLEGRIDY Injection, Oncaspar, Jafaki, Keytruda Injection, Promacta tablet, Imbruvica capsules and Avonex injection.&nbsp;&nbsp;<br />
With more than 30 years of experience as a generic medicine exporter we have developed a strong global network of retail pharmacies. Through these relationships we can obtain and export most specialties, often unavailable through regular sources, quickly and efficiently. These pharmacies are based in London, Brussels, Madrid, New York, Paris, Singapore and Sydney.</p>
<p><br />
We export across Europe, the Middle East and Africa. With our unparalleled customer service and extensive stock of products we are confident that we will be able to fulfil your requirements. For more details about our generic medicines exports and other services, please contact us on</p>
<p><br />
+44 (0) 208 952 2061&nbsp;</p>Tysabri Drug Supplierhttp://www.derekclarke.com/services/tysabri-drug-supplier/36
http://www.derekclarke.com/services/tysabri-drug-supplier/36<p>Derek Clarke is a reputable Tysabri drug supplier.</p>
<p><br />
Tsyabri (natalizumab, Biogen Idec) is indicated for adults with relapsing forms of multiple sclerosis (MS). It is administered by a healthcare professional as a monthly infusion.</p>
<p><br />
Tysabri is available for:</p>
<p>&nbsp;</p>
<ul>
<li>&lsquo;aggressive multiple sclerosis&rsquo; &ndash; people who have had two or more disabling relapses in one year, and an increase in lesions as shown on an MRI scan</li>
<li>people who have had an increase in the number or severity of relapses while taking another drug</li>
</ul>
<p><br />
Tysabri is an antibody that prevents certain immune cells from leaving the blood stream and entering the brain and spinal cord which, in MS, causes inflammation and damage.</p>
<p><br />
A two-year study showed that people on Tysabri had a 67% reduction in the number of relapses, compared to what would be expected if no treatment had been taken.</p>
<p><br />
Tysabri also slowed the accumulation of disability over two years. Only 17% of people taking the drug had worse disability, compared with 29% of people on placebo.</p>
<p><br />
The drug is generally well tolerated but can cause side-effects, including progressive multifocal leukoencephalopathy (PML), a rare but potentially fatal infection.</p>
<p><br />
PML (progressive multifocal leukoencephalopathy) is caused by a viral infection in the brain and can lead to death or disability. Several people treated with Tysabri have died because of PML. Analysis of the number of cases of PML suggests that about 1 in every 500 people treated with Tysabri are at risk of developing the infection.</p>
<p><br />
It is important that professionals and patients are aware of the risks of PML, recognise the early signs and know what to do if they notice these signs.</p>
<p><br />
Longer-term benefits of Tysabri are unknown.</p>
<p><br />
Derek Clarke, with more than 30 years as experience as an exporter of both branded and generics drugs, is able to source and supply products, often unavailable through other sources, quickly and efficiently.&nbsp;&nbsp;</p>
<p><br />
For more information on our Tysabri drug supplies please contact us on</p>
<p>+44 (0) 208 952 2061</p>Tracleer Drug Exportershttp://www.derekclarke.com/services/tracleer-drug-exporters/37
http://www.derekclarke.com/services/tracleer-drug-exporters/37<p>Derek Clarke is a trusted Tracleer drug exporter.</p>
<p><br />
Tracleer (bosetan, Actelion) is indicated for the treatment of pulmonary arterial hypertension (PAH) (WHO Group 1) to improve exercise ability and to decrease clinical worsening. PAH is high blood pressure in the vessels of the lung.</p>
<p><br />
Tracleer has been shown to improve patients&rsquo; ability to exercise as measured by a 6-minute walk test and can slow the worsening of physical condition and symptoms.</p>
<p><br />
Some improvements have also been shown in reducing the worsening of PAH in patients with Functional Class II symptoms.&nbsp;</p>
<p><br />
In Europe, Tracleer is approved for reducing the number of new digital ulcers in patients with systemic sclerosis and ongoing digital ulcer disease.</p>
<p><br />
It is important to note that Tracleer can cause side-effects including liver damage.</p>
<p><br />
Derek Clarke, with more than 30 years as experience as an exporter of both branded and generics drugs, is able to source and supply products, often unavailable through other sources, quickly and efficiently.&nbsp;&nbsp;</p>
<p><br />
For more details on our Tracleer drug exports, please contact us on</p>
<p>+44 (0) 208 952 2061</p>Tecfidera Medicine Exportershttp://www.derekclarke.com/services/tecfidera-medicine-exporters/38
http://www.derekclarke.com/services/tecfidera-medicine-exporters/38<p>Derek Clarke is a leading UK-based Tecfidera medicine exporter.</p>
<p><br />
Tecfidera (dimethyl fumarate, Biogen Idec) is an oral treatment approved for the treatment of relapsing forms of multiple sclerosis (MS), the most common form of MS.</p>
<p><br />
In two phase 3 clinical trials, Tecfidera was shown to significantly reduce relapse rates and disability progression compared to both placebo and the comparator Copaxone (glatiramer acetate).</p>
<p><br />
In the first trial, DEFINE, Tecfidera was shown to reduce relapse rates by between 48% and 53%, and disability progression by between 34% and 38% compared to placebo.</p>
<p><br />
The second trial, CONFIRM, showed that Tecfidera reduced relapse rates by between 44% and 51%, compared to a 29% reduction in those taking Copaxone. It also reduced disability progression by between 21% and 24%, compared to 7% for Copaxone.</p>
<p><br />
MRI scans in both trials also showed a significant reduction in new or newly enlarging brain lesions, the damage caused by MS, after two years in those treated with Tecfidera compared with those treated with either placebo or Copaxone.</p>
<p><br />
It is important to note that Tecfidera can cause side-effects and these should be discussed with healthcare professionals.</p>
<p><br />
Derek Clarke, with more than 30 years as experience as an exporter of both branded and generics drugs, is able to source and supply products, often unavailable through other sources, quickly and efficiently.&nbsp;&nbsp;</p>
<p><br />
For more information on our Tecfidera medicine exports, please contact us on</p>
<p><br />
+44 (0) 208 952 2061</p>Tecfidera Pill Supplierhttp://www.derekclarke.com/services/tecfidera-pill-supplier/39
http://www.derekclarke.com/services/tecfidera-pill-supplier/39<p>Derek Clarke is a leading UK-based Tecfidera pill supplier to healthcare professionals worldwide.</p>
<p><br />
Tecfidera (dimethyl fumarate, Biogen Idec) is an oral therapy approved for the treatment of relapsing forms of multiple sclerosis (MS), the most common form of MS.</p>
<p><br />
In two phase 3 clinical trials, Tecfidera was shown to significantly reduce relapse rates and disability progression compared to both placebo and the comparator Copaxone (glatiramer acetate).</p>
<p><br />
In the first trial, DEFINE, Tecfidera was shown to reduce relapse rates by between 48% and 53%, and disability progression by between 34% and 38% compared to placebo.</p>
<p><br />
The second trial, CONFIRM, showed that Tecfidera reduced relapse rates by between 44% and 51%, compared to a 29% reduction in those taking Copaxone. It also reduced disability progression by between 21% and 24%, compared to 7% for Copaxone.</p>
<p><br />
MRI scans in both trials also showed a significant reduction in new or newly enlarging brain lesions, the damage caused by MS, after two years in those treated with Tecfidera compared with those treated with either placebo or Copaxone.</p>
<p><br />
It is important to note that Tecfidera can cause side-effects and these should be discussed with healthcare professionals.</p>
<p><br />
Derek Clarke, with more than 30 years as experience as an exporter of both branded and generics medicines, is able to source and supply products, often unavailable through other sources, quickly and efficiently.&nbsp;&nbsp;</p>
<p><br />
For more information on our Tecfidera medicine exports, please contact us on</p>
<p><br />
+44 (0) 208 952 2061</p>Opdivo Capsules Onlinehttp://www.derekclarke.com/services/opdivo-capsules-online/40
http://www.derekclarke.com/services/opdivo-capsules-online/40<p>Derek Clarke is one of the few UK-based suppliers of Opdivo capsules online.</p>
<p><br />
Opdivo (nivolumab, Bristol-Myers Squibb), is a human programmed death receptor-1 (PD-1) blocking antibody indicated for the treatment of patients with unresectable or metastatic melanoma and disease progression following Yervoy&reg; (ipilimumab) and, if BRAF V600 mutation positive, a BRAF inhibitor. It is administered intravenously.</p>
<p><br />
Metastatic melanoma is the deadliest form of skin cancer.</p>
<p><br />
This indication for Opdivo is approved by the Food and Drug Administration under its accelerated approval based on tumour response rate and durability of response. Continued approval for this indication may be contingent upon verification and description of clinical benefit in the confirmatory trials.</p>
<p><br />
Derek Clarke, with more than 30 years as experience as an exporter of both branded and generics medicines, is able to source and supply products, often unavailable through other sources, quickly and efficiently.</p>
<p><br />
As part of our service we offer an authorised and fully compliant online pharmacy. Our online medical prescription services are particularly beneficial to foreign healthcare professionals who can order what they require safely at the touch of a button.</p>
<p><br />
Please contact us to find out more about obtaining Opdivo capsules online</p>
<p>&nbsp;</p>
<p>+44 (0) 208 952 2061</p>Export of Plegridy Injectionhttp://www.derekclarke.com/services/export-of-plegridy-injection/41
http://www.derekclarke.com/services/export-of-plegridy-injection/41<p>Derek Clarke is an established exporter of PLEGRIDY Injection to healthcare professionals around the world.&nbsp;</p>
<p><br />
PLEGRIDY injection (peginterferon beta-1a, Biogen Idec) is a subcutaneous injectable therapy for relapsing forms of multiple sclerosis (RMS). PLEGRIDY injection is the only pegylated interferon approved for the treatment of RMS and is administered every two weeks.<br />
MS is an auto-immune disease of the central nervous system, whereby the immune system attacks nerve cells and causes scars or lesions within the CNS. Common symptoms of MS include:</p>
<p>&nbsp;</p>
<p>&nbsp;</p>
<ul>
<li>Fatigue</li>
<li>Optic Neuritis (Loss of vision in one eye, blurred or double vision)</li>
<li>Weakness of limbs</li>
<li>Reduced co-ordination</li>
<li>Balance problems</li>
<li>Numbness</li>
<li>Pins &amp; needles</li>
</ul>
<p><br />
Derek Clarke, with more than 30 years as experience as an exporter of both branded and generics medicines, is able to source and supply products, often unavailable through other sources, quickly and efficiently.</p>
<p><br />
For more information on the export of PLEGRIDY injection, please contact us on</p>
<p><br />
+44 (0) 208 952 2061</p>Oncaspar Supplierhttp://www.derekclarke.com/services/oncaspar-supplier/42
http://www.derekclarke.com/services/oncaspar-supplier/42<p>Derek Clarke is a supplier of Oncaspar to healthcare professionals around the world.</p>
<p><br />
Oncaspar (pegaspargase, Sigma Tau) is indicated as a component of a multi-agent chemotherapeutic regimen for the first line treatment of patients with acute lymphoblastic leukemia (ALL) and for the treatment of patients with ALL and hypersensitivity to native forms of L-asparaginase.</p>
<p><br />
Oncaspar is the only approved pegylated formulation approved by the US Food and Drug Administration (FDA) of L-asparaginase, the enzyme that depletes the amino acid asparagine. While normal cells can produce asparagine, leukemic cells are unable to produce enough asparagine to survive on their own.</p>
<p><br />
L-asparaginase is given to ALL patients to ensure depletion of asparagine that is circulating in the blood. Depletion (starving the leukemic cells) of asparagine ultimately results in leukemic cell death.</p>
<p><br />
Oncaspar is administered through intramuscular (IM) injection or intravenous (IV) infusion.</p>
<p><br />
Derek Clarke, with more than 30 years as experience as an exporter of both branded and generics medicines, is able to source and supply products, often unavailable through other sources, quickly and efficiently.</p>
<p><br />
Please contact us for more information on our Oncaspar supplies.</p>
<p><br />
+44 (0) 208 952 2061</p>Jakafi Exporters Onlinehttp://www.derekclarke.com/services/jakafi-exporters-online/43
http://www.derekclarke.com/services/jakafi-exporters-online/43<p>We source and provide Jakafi exports online.</p>
<p><br />
Jakafi (ruxolitinib, Incyte/Novartis) is a first-in-class JAK1/JAK2 inhibitor approved by the US Food and Drug Administration for treatment of people with polycythemia vera, a chronic type of bone marrow disease, who have had an inadequate response to or are intolerant of hydroxyurea.</p>
<p><br />
Polycythemia vera is characterised by too many blood cells in the bone marrow which can cause the spleen to swell, bleeding problems and blood clots in the veins near the skin surface (phlebitis). In addition, it can increase the risk of stroke or heart attack.<br />
Jakafi is the first treatment approved by the US Food and Drug Administration (FDA) for this condition. It is expected that the drug will reduce the occurrence of an enlarged spleen (splenomegaly) and the need for phlebotomy, a procedure to remove excess blood from the body.</p>
<p><br />
The most common side effects in patients with polycythemia vera were low red blood cell counts (anemia) and low blood platelet counts (thrombocytopenia). The most common non-blood related side effects were dizziness, constipation and shingles.</p>
<p><br />
The drug is also indicated for treatment of people with intermediate or high-risk myelofibrosis (MF), including primary MF, post&ndash;polycythemia vera MF, and post-essential thrombocythemia MF.</p>
<p><br />
Derek Clarke, with more than 30 years as experience as an exporter of both branded and generics medicines, is able to source and supply products, often unavailable through other sources, quickly and efficiently.</p>
<p><br />
As part of our service we offer an authorised and fully compliant online pharmacy. Our online medical prescription services are particularly beneficial to foreign healthcare professionals who can order what they require safely at the touch of a button.</p>
<p><br />
As a recommended Jakafi exporter online, please contact us for more information.</p>
<p><br />
+44 (0) 208 952 2061</p>Keytruda Injection Supplierhttp://www.derekclarke.com/services/keytruda-injection-supplier/44
http://www.derekclarke.com/services/keytruda-injection-supplier/44<p>Derek Clarke is recognised as a Keytruda Injection supplier.</p>
<p><br />
Keytruda (prembolizumab, Merck) is a human programmed death receptor-1 (PD-1)-blocking antibody indicated for the treatment of patients with unresectable or metastatic melanoma and disease progression following ipilimumab and, if BRAF V600 mutation positive, a BRAF inhibitor.</p>
<p><br />
Keytruda is the first approved drug that blocks the PD-1 cellular pathway, which restricts the body&rsquo;s immune system from attacking melanoma cells. The drug is administered as an intravenous infusion every three weeks.</p>
<p><br />
The US Food and Drug Administration (FDA) granted Keytruda breakthrough therapy designation on the basis of demonstrating preliminary clinical evidence that the drug may offer a substantial improvement over available therapies. Keytruda was also granted priority review and orphan product designation.</p>
<p><br />
Keytruda&rsquo;s efficacy was established in 173 clinical trial participants with advanced melanoma whose disease progressed after prior treatment. If half of the clinical trial participants given the recommended dose of 2mg/kg, tumours shrank in 24% of people. This effect lasted for at least 1.4 to 8.5 months and continued beyond this period in most patients. The tumours shrank in a similar percentage of patients given the 10 mg/kg dose.</p>
<p><br />
Keytruda&rsquo;s safety was established in the trial population of 411 participants with advanced melanoma. The most common side effects of Keytruda were fatigue, cough, nausea, itchy skin (pruritus), rash, decreased appetite, constipation, joint pain (arthralgia) and diarrhea. Keytruda also has the potential for severe immune-mediated side effects.</p>
<p><br />
Derek Clarke, with more than 30 years as experience as an exporter of both branded and generics medicines, is able to source and supply products, often unavailable through other sources, quickly and efficiently.</p>
<p><br />
Please contact us for more information on our Keytruda injection supplies.</p>
<p><br />
+44 (0) 208 952 2061</p>Promacta Tablet Supplierhttp://www.derekclarke.com/services/promacta-tablet-supplier/45
http://www.derekclarke.com/services/promacta-tablet-supplier/45<p>Derek Clarke is a trusted Promacta tablet supplier.</p>
<p>&nbsp;</p>
<p>Promacta (eltrombopag, GlaxoSmithKline) is indicated for:</p>
<p>&nbsp;</p>
<ul>
<li>Treatment of low blood platelet counts in people with chronic immune (Idiopathic) thrombocytopenia, when either corticosteroids, immunoglobulins or surgery to remove the spleen have not worked well enough.</li>
<li>Treatment of low blood platelet counts in people with chronic hepatitis C virus (HCV) infection before and during treatment with interferon.</li>
</ul>
<p><br />
In 2014, Promacta was also approved for use in patients with severe aplastic anaemia (SAA) who have had an insufficient response to immunosuppressive therapy. SAA is a blood disorder where the bone marrow fails to make enough red blood cells, white blood cells, and platelets. The drug helps to increase the production of blood cells by inducing proliferation and differentiation of bone marrow stem cells.</p>
<p><br />
Please contact the manufacturer for safety information about Promacta.</p>
<p><br />
Derek Clarke, with more than 30 years as experience as an exporter of both branded and generics medicines, is able to source and supply products, often unavailable through other sources, quickly and efficiently.</p>
<p><br />
For more information about Derek Clarke as a Promacta tablet supplier please contact us on</p>
<p><br />
+44 (0) 208 952 2061</p>Imbruvica Capsules Exporterhttp://www.derekclarke.com/services/imbruvica-capsules-exporter/46
http://www.derekclarke.com/services/imbruvica-capsules-exporter/46<p>Derek Clarke is a reputable Imbruvica capsules exporter.</p>
<p><br />
Imbuvica (ibrutinib, Pharmacyclics/Janssen Biotech) is indicated to treat the following conditions:</p>
<p>&nbsp;</p>
<p>&nbsp;</p>
<ul>
<li>Chronic lymphocytic leukemia (CLL) who have received at least one prior treatment</li>
<li>Chronic lymphocytic leukemia (CLL) with 17p deletion</li>
<li>Waldenstr&ouml;m's macroglobulinemia (WM)</li>
<li>Mantle cell lymphoma (MCL) who have received at least one prior treatment</li>
</ul>
<p><br />
The US Food and Drug Administration (FDA) granted Imbruvica accelerated approval for CLL. CLL is a progressive rare blood and bone marrow disease that causes a gradual increase in white blood cells called B lymphocytes, or B cells.</p>
<p><br />
The FDA&rsquo;s accelerated approval of Imbruvica for CLL is based on a clinical study of 48 previously treated participants. On average, participants were diagnosed with CLL 6.7 years prior to the study and had received four previous therapies.</p>
<p>&nbsp;</p>
<ul>
<li>Results showed that after treatment (overall response rate) with Imbruvica, the cancer shrank in nearly 58% of participants. At the time of the study, the duration of response ranged from 5.6 to 24.2 months. An improvement in survival or disease-related symptoms has not been established.</li>
</ul>
<p><br />
The most common side effects observed in the clinical study include low levels of platelets in the blood (thrombocytopenia), diarrhea, bruising, a decrease in infection-fighting white blood cells (neutropenia), low red blood cells (anemia), upper respiratory tract infection, fatigue, pain in the muscles and bones (musculoskeletal pain), rash, fever (pyrexia), constipation, swelling of tissues (peripheral edema), joint pain (arthralgia), nausea, mouth sores (stomatitis), sinus infection (sinusitis) and dizziness.</p>
<p><br />
Derek Clarke, with more than 30 years as experience as an exporter of both branded and generics medicines, is able to source and supply products, often unavailable through other sources, quickly and efficiently.</p>
<p><br />
For more information on our supplies and exports of Imbruvica capsules please contact us on</p>
<p>&nbsp;</p>
<p>+44 (0) 208 952 2061</p>Supplier of Avonex Injectionhttp://www.derekclarke.com/services/supplier-of-avonex-injection/47
http://www.derekclarke.com/services/supplier-of-avonex-injection/47<p>Derek Clarke is a well-established supplier of Avonex injection.</p>
<p><br />
Avonex (interferon beta-1a, Biogen Idec) is approved by the US Food and Drug Administration (FDA) for the treatment of relapsing forms of multiple sclerosis (MS) to decrease the number of flare-ups and to slow the occurrence of some of the physical disability that is common in people with MS. Avonex injection is approved for use in people who have experienced a first attack and have lesions consistent with MS on their MRI scans.</p>
<p><br />
In clinical trials in relapsing MS, Avonex was shown to have the following benefits:</p>
<p>&nbsp;</p>
<ul>
<li>Reduced risk of disability progression</li>
<li>Fewer exacerbations</li>
<li>Reduction in the number and size of active lesions in the brain (as shown on MRI) compared with placebo</li>
</ul>
<p><br />
In a subsequent study of patients who had experienced a single demyelinating event in the optic nerve, spinal cord, or brainstem, and had lesions typical of MS on brain MRI, Avonex was shown to significantly delay the time to a second exacerbation, and thus to a clinically definite diagnosis of MS.</p>
<p><br />
In 2012, the FDA approved the AVONEX PEN single-use prefilled autoinjector. It contains the same dose of medication (30 micrograms) as the prefilled syringe and the powder vial.</p>
<p><br />
Avonex is given once a week as an intramuscular injection.</p>
<p><br />
During the initial weeks of starting treatment with Avonex injection, flu-like symptoms are common side-effects. The FDA has added warnings and precautions to the prescribing information following post-marketing findings.</p>
<p><br />
Derek Clarke, with more than 30 years experience as an exporter of both branded and generics medicines, is able to source and supply products, often unavailable through other sources, quickly and efficiently.</p>
<p><br />
For more information on our supplies of Avonex injection please contact us on<br />
&nbsp;</p>
<p>+44 (0) 208 952 2061</p>KUVAN Tablets Supplierhttp://www.derekclarke.com/services/kuvan-tablets-supplier/48
http://www.derekclarke.com/services/kuvan-tablets-supplier/48<p>Derek Clarke is a leading UK-based KUVAN Tablets Supplier</p>
<p>&nbsp;</p>
<p>KUVAN (sapropterin dihydrochloride) Tablets for Oral Use and Powder for Oral Solution are approved to reduce blood Phe levels in people with a certain type of Phenylketonuria (PKU). KUVAN is to be used with a Phe-restricted diet.</p>
<p>&nbsp;</p>
<p>Important Safety Information</p>
<p>&nbsp;</p>
<p>It is not possible to know if KUVAN will work for you without a trial of the medicine. Your doctor will check your blood Phe levels when you start taking KUVAN to see if the medicine is working.</p>
<p>&nbsp;</p>
<p>Starting KUVAN does not eliminate the need for ongoing dietary management. Any change to your diet may impact your blood Phe level. Follow your doctor's instructions carefully. Your doctor and dietitian will continue to monitor your diet and blood Phe levels throughout your treatment with KUVAN <strong>to make sure your blood Phe levels are not too high or too low</strong>. If you have a fever, or if you are sick, your Phe level may go up. Tell your doctor and dietitian as soon as possible so they can make any necessary changes to your treatment.</p>
<p>&nbsp;</p>
<p>Children younger than 7 years old treated with KUVAN doses of 20 mg/kg per day are at an increased risk for low levels of blood Phe compared with children 7 years and older. Frequent blood monitoring is recommended in this population to ensure that blood Phe levels do not fall too low.</p>
<p>&nbsp;</p>
<p>Tell your doctor if you have ever had liver or kidney problems, have poor nutrition or have a loss of appetite, are pregnant or plan to become pregnant, or are breastfeeding or plan to breastfeed.</p>
<p>&nbsp;</p>
<p>KUVAN is a prescription medicine and should not be taken by people who are allergic to any of its ingredients. KUVAN and other medicines may interact with each other. Tell your doctor about <strong>all the medicines you take</strong>, including prescription and over-the-counter medicines, vitamins, herbal and dietary supplements.</p>
<p>&nbsp;</p>
<p>If you forget to take your dose of KUVAN, take it as soon as you remember that day. Do not take 2 doses in a day. If you take too much KUVAN, call your doctor for advice.</p>
<p>&nbsp;</p>
<p>The most common side effects reported when using KUVAN are headache, runny nose and nasal congestion, sore throat, diarrhea, vomiting, and cough. Additional adverse reactions reported in connection with worldwide marketing include sore throat, heartburn or pain in the esophagus, inflammation of the lining of the stomach, indigestion, stomach pain, and nausea. These are not all the possible side effects seen with KUVAN. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.</p>
<p>&nbsp;</p>
<p>It is important to note that KUVAN can cause side-effects and these should be discussed with healthcare professionals.</p>
<p>&nbsp;</p>
<p>Derek Clarke, with more than 30 years as experience as an exporter of both branded and generics drugs, is able to source and supply products, often unavailable through other sources, quickly and efficiently.&nbsp;&nbsp;</p>Aubagio Tablethttp://www.derekclarke.com/services/aubagio-tablet/49
http://www.derekclarke.com/services/aubagio-tablet/49<p>Derek Clarke is a well-established supplier of Aubagio.</p>
<p>&nbsp;</p>
<p>Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.</p>
<p>&nbsp;</p>
<p>Stop using teriflunomide and call your doctor at once if you have:<br />
fever, chills, body aches, flu symptoms, sores in your mouth and throat;<br />
nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);<br />
fast or racing heartbeats;</p>
<p>&nbsp;</p>
<p><br />
numbness or tingling in your hands or feet that feels different from your regular MS symptoms;<br />
pain in your side or lower back, confusion, little or no urinating;<br />
chest pain, dry cough, wheezing, feeling short of breath;<br />
skin redness or peeling;<br />
swelling, rapid weight gain; or<br />
severe skin reaction -- fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.</p>
<p>Common side effects may include:</p>
<p><br />
diarrhea;<br />
thinning hair; or<br />
burning or prickly feeing in your skin.</p>
<p>It is important to note that Aubagio can cause side-effects and these should be discussed with healthcare professionals.</p>
<p><br />
Derek Clarke, with more than 30 years as experience as an exporter of both branded and generics drugs, is able to source and supply products, often unavailable through other sources, quickly and efficiently.&nbsp;</p>ZYDELIG Tablethttp://www.derekclarke.com/services/zydelig-tablet/50
http://www.derekclarke.com/services/zydelig-tablet/50<p>Derek Clarke is a well-established supplier of ZYDELIG 100mg or 150mg.</p>
<p>&nbsp;</p>
<p><strong>What this drug is used for:</strong></p>
<p>&nbsp;</p>
<p>Chronic lymphocytic leukemia:&nbsp; Treatment of relapsed chronic lymphocytic leukemia (CLL) (in combination with rituximab) when rituximab alone is appropriate therapy due to other comorbidities.</p>
<p>&nbsp;</p>
<p>Follicular B-cell non-Hodgkin lymphoma:&nbsp; Treatment of relapsed follicular B-cell non-Hodgkin lymphoma after at least 2 prior systemic therapies.</p>
<p>&nbsp;</p>
<p>Small lymphocytic lymphoma: Treatment of relapsed small lymphocytic lymphoma (SLL) after at least 2 prior systemic therapies.</p>
<p>&nbsp;</p>
<p>Note: If a drug has been approved for one use, physicians may elect to use this same drug for other problems if they believe it may be helpful.</p>
<p>&nbsp;</p>
<p><strong>How this drug is given:</strong></p>
<p><br />
&bull;Zydelig&reg; is a tablet, taken by mouth: the recommended maximum starting dose is 150mg administered orally twice daily. It can be taken with or without food.</p>
<p><br />
&bull;Dosage may be adjusted based on side effects.<br />
&bull;Take Zydelig&reg; exactly as prescribed.<br />
&bull;Swallow Zydelig&reg; tablets whole. Do not crush or dissolve tablets.<br />
&bull;Do not change your dose or stop Zydelig&reg;. If you miss a dose of Zydelig&reg; by less than 6 hours, take the missed dose right away. Then take your next dose as usual. If you miss a dose of Zydelig&reg; by more than 6 hours, wait and take the next dose of Zydelig&reg; at your usual time.<br />
&bull;Do not take more than 1 dose of Zydelig&reg; at one time. Call your health care provider right away if you take too much.<br />
&bull;The amount of Zydelig&reg; that you will receive depends on many factors, your general health or other health problems, and the type of cancer or condition being treated.</p>
<p><strong>Side effects:</strong></p>
<p><br />
&nbsp;Important things to remember about the side effects of Zydelig&reg;:<br />
&bull;Most people do not experience all of the side effects listed.<br />
&bull;Side effects are often predictable in terms of their onset and duration.<br />
&bull;Side effects are almost always reversible and will go away after treatment is complete.<br />
&bull;There are many options to help minimize or prevent side effects.<br />
&bull;There is no relationship between the presence or severity of side effects and the effectiveness of the medication.</p>
<p><strong>Side effects in patients with CLL taking Zydelig&reg; monotherapy:</strong></p>
<p>&nbsp;</p>
<p>The following side effects are common (occurring in greater than 30%) for patients taking&nbsp; Zydelig&reg; &amp; Rituxin:<br />
&bull; Neutrophil count decreased<br />
&bull; Hypertriglyceridemia<br />
&bull; Hyperglycemia<br />
&bull; ALT increased<br />
&bull; Fever</p>
<p>These side effects are less common side effects (occurring in about 10-29%) of patients receiving&nbsp; Zydelig&reg; &amp; Rituxin:<br />
&bull; GGT increased<br />
&bull; Nausea<br />
&bull; Lymphocyte count increased<br />
&bull; AST increased<br />
&bull; Pneumonia<br />
&bull; Chills<br />
&bull; Diarrhea<br />
&bull; Lymphocyte count decreased<br />
&bull; Hyponatremia<br />
&bull; Rash<br />
&bull; Vomiting<br />
&bull; Hypoglycemia<br />
&bull; Headache</p>
<p>Side effects in patients with indolent non-Hodgkin lymphoma taking only Zydelig&reg;</p>
<p>The following side effects are common (occurring in greater than 30%) for patients taking&nbsp; Zydelig&reg; monotherapy:<br />
&bull; Neutrophils decreased<br />
&bull; ALT increased<br />
&bull; Diarrhea<br />
&bull; AST increased<br />
&bull; Fatigue<br />
&bull; Cough<br />
&bull; Nausea<br />
&bull; Fever<br />
&bull; Hemaglobin decreased<br />
&bull; Platelets decreased<br />
&bull; Abdominal pain<br />
&bull; Pneumonia<br />
&bull; Rash</p>
<p>These side effects are less common side effects (occurring in about 10-29%) of patients receiving&nbsp; Zydelig&reg; monotherapy:<br />
&bull; Shortness of breath<br />
&bull; Decreased appetite<br />
&bull; Vomiting<br />
&bull; Upper respiratory tract infection<br />
&bull;Night sweats<br />
&bull; Asthenia<br />
&bull; Insomnia<br />
&bull; Headache<br />
&bull; Swelling</p>
<p>Some more uncommon, but very serious side effects of Zydelig&reg; are:</p>
<p>Liver problems . Your provider will do blood tests before and during your treatment with Zydelig&reg; to check for liver problems. Contact your provider right away if you get any of the following symptoms of liver problems:</p>
<p>&middot; Yellowing of your skin or the white part of your eye (jaundice)<br />
&bull;Dark or brown urine</p>
<p>&middot; Pain in the upper right side of your stomach area</p>
<p>&middot; Bleeding or bruising more easily than normal</p>
<p>Severe diarrhea or colitis. Diarrhea is common with Zydelig&reg; and can sometimes be severe. Tell your provider right away if the number of bowel movements you have in a day increases up to 4-6 or more.</p>
<p>Lung or breathing problems (pneumonitis). Tell your provider right away if you develop a new or worsening cough, shortness of breath, difficulty breathing or wheezing.</p>
<p>Tear in the intestinal wall (perforation). Tell your provider and seek help right away if you develop new or worsening stomach pain, chills, fever, nausea, or vomiting.</p>
<p>&nbsp;</p>
<p>Not all side effects are listed above. Some that are rare (occurring in less than 10% of patients) are not listed here. However, you should always inform your health care provider if you experience any unusual symptoms.&nbsp;</p>
<p>&nbsp;</p>
<p>&nbsp;</p>
<p>When to contact your doctor or health care provider:</p>
<p>Contact your health care provider immediately, day or night, if you should experience any of the following symptoms:&nbsp;<br />
&bull;Fever of 100.4&deg; F (38&deg; or higher, chills)<br />
&bull;Sudden onset of shortness of breath, cough, shortness of breath, difficulty breathing or wheezing&nbsp;<br />
&bull;New or worsening stomach pain, chills, fever, nausea, or vomiting</p>
<p>The following symptoms require medical attention, but are not an emergency. Contact your health care provider within 24 hours of noticing any of the following:&nbsp;<br />
&bull;Diarrhea (4-6 episodes in a 24-hour period)<br />
&bull;Nausea (interferes with ability to eat and unrelieved with prescribed medication).<br />
&bull;Unable to eat or drink for 24 hours or have signs of dehydration: tiredness, thirst, dry mouth, dark and decrease amount of urine, or dizziness<br />
&bull;Skin or the whites of your eyes turn yellow<br />
&bull;Itchy skin<br />
&bull;Urine turns dark or brown (tea color)<br />
&bull;Decreased appetite<br />
&bull;Signs of an infection (cough with or without mucus, nasal drainage, burning with urination, redness or swelling, pus formation at the site of an injury or incision)<br />
&bull;Fatigue that interfere with activities of daily living (showering, bathing, making meals, etc.)<br />
&bull;Painful sores or ulcers on your skin, lips or in your mouth<br />
&bull;Rash, blisters, or peeling skin</p>
<p>Always inform your health care provider if you experience any unusual symptoms.</p>
<p>Precautions:<br />
&bull;Before starting Zydelig&reg; treatment, make sure you tell your doctor about any other medications you are taking (including prescription, over-the-counter, vitamins, herbal remedies, etc.).<br />
&bull;Do not receive any kind of immunization or vaccination without your doctor's approval while taking Zydelig&reg;<br />
&bull;Inform your health care professional if you are pregnant or may be pregnant prior to starting this treatment. Pregnancy category D (Zydelig&reg; may be hazardous to the fetus. Women who are pregnant or become pregnant must be advised of the potential hazard to the fetus).<br />
&bull;For both men and women: Do not conceive a child (get pregnant) while taking Zydelig&reg;. Barrier methods of contraception, such as condoms, are recommended during treatment and for at least 1 month after completing therapy. Discuss with your doctor when you may safely become pregnant or conceive a child after therapy.<br />
&bull;Do not breast feed while taking this medication.</p>
<p>Self-care tips:<br />
&bull;Drink at least two to three quarts of fluid every 24 hours, unless you are instructed otherwise.<br />
&bull;If you should experience nausea, take anti-nausea medications as prescribed by your doctor, and eat small frequent meals. Sucking on lozenges and chewing gum may also help.<br />
&bull;Avoid sun exposure. Wear SPF 15 (or higher) sun block and protective clothing.<br />
&bull;In general, drinking alcoholic beverages should be kept to a minimum or avoided completely. You should discuss this with your doctor.<br />
&bull;Get plenty of rest.<br />
&bull;Maintain good nutrition.</p>
<p>&middot; You may be at risk of infection so try to avoid crowds or people with colds, and report fever or any other signs of infection immediately to your healthcare provider.</p>
<p>&middot; Wash your hands often. Do not touch your eyes or the inside of your nose unless you have just washed your hands and have not touched anything else in the meantime.</p>
<p>&middot; Ask your doctor or nurse before scheduling dental appointments or procedures.</p>
<p>&middot; Use an electric razor to minimize bleeding.</p>
<p>&middot; If you experience symptoms or side effects, be sure to discuss them with your health care team. They can prescribe medications and/or offer other suggestions that are effective in managing such problems.</p>
<p>Monitoring and testing:</p>
<p>You will be checked regularly by your health care professional while you are taking Zydelig&reg; to monitor side effects and check your response to therapy.</p>
<p>How this drug works:</p>
<p>Targeted therapy is the result of about 100 years of research dedicated to understanding the differences between cancer cells and normal cells. To date, cancer treatment has focused primarily on killing rapidly dividing cells because one feature of cancer cells is that they divide rapidly. Unfortunately, some of our normal cells divide rapidly too, causing multiple side effects.</p>
<p>Targeted therapy is about identifying other features of cancer cells. Scientists look for specific differences in the cancer cells and the normal cells. This information is used to create a targeted therapy to attack the cancer cells without damaging the normal cells, thus leading to fewer side effects. Each type of targeted therapy works a little bit differently but all interfere with the ability of the cancer cell to grow, divide, repair and/or communicate with other cells.</p>
<p>There are different types of targeted therapies, defined in three broad categories. Some targeted therapies focus on the internal components and function of the cancer cell. The targeted therapies use small molecules that can get into the cell and disrupt the function of the cells, causing them to die. There are several types of targeted therapy that focus on the inner parts of the cells. Other targeted therapies target receptors that are on the outside of the cell. Therapies that target receptors are also known as monoclonal antibodies. Antiangiogenesis inhibitors target the blood vessels that supply oxygen to the cells, ultimately causing the cells to starve.</p>
<p>Zydelig&reg; is a targeted therapy. Zydelig&reg; is an oral inhibitor of phosphoinositide 3-kinase (PI3K) delta, a protein that plays a role in the activation, proliferation and viability of B cells, a critical component of the immune system. PI3K delta signaling is active in many B-cell leukemias and lymphomas, and by inhibiting the protein, Zydelig&reg; blocks several cellular signaling pathways that drive B-cell viability. By binding to these receptors Zydelig&reg; blocks an important pathway that promotes cell division.</p>
<p>Research continues to identify which cancers may be best treated with targeted therapies and to identify additional targets for more types of cancer.</p>
<p>Note: We strongly encourage you to talk with your health care professional about your specific medical condition and treatments. The information contained in this website is meant to be helpful and educational, but is not a substitute for medical advice.</p>
<p>It is important to note that ZYDELIG can cause side-effects and these should be discussed with healthcare professionals.</p>
<p><br />
Derek Clarke, with more than 30 years as experience as an exporter of both branded and generics drugs, is able to source and supply products, often unavailable through other sources, quickly and efficiently.&nbsp;</p>Orfadinhttp://www.derekclarke.com/services/orfadin/51
http://www.derekclarke.com/services/orfadin/51<p>Derek Clarke is a leading UK-based supplier of <span style="font-family:calibri,sans-serif; font-size:11pt">ORFADIN 5MG CAP &amp; &nbsp;10MG </span></p>
<p>&nbsp;</p>
<p><span style="font-family:calibri,sans-serif; font-size:11pt">WE CAN SUPPLY TO HOSPITALS ON SPECIAL ORDER,&nbsp; COOL STORAGE LINE.&nbsp; (2-8) C </span></p>
<p>&nbsp;</p>
<p>Nitisinone is used to treat a certain inherited disorder (hereditary tyrosinemia type 1, also known as HT-1). HT-1 is usually discovered in infants and needs lifelong treatment. This condition is caused by a shortage of a certain natural substance that is needed to break down a nutrient (tyrosine) found in food. This effect causes a build-up of too much tyrosine and related substances in the liver. Nitisinone works by helping to prevent the formation and build-up of several toxic substances that cause damage to the liver, kidneys, and nervous system. This drug must be used along with a diet low in protein, tyrosine, and phenylalanine.</p>
<p>&nbsp;</p>Guaiacol CAS 90-05-1http://www.derekclarke.com/services/guaiacol-cas-90-05-1/52
http://www.derekclarke.com/services/guaiacol-cas-90-05-1/52<p>Derek Clarke is a leading UK-based Supplier of Guaiacol CAS 90-05-1</p>
<p>&nbsp;</p>
<p>Overview:</p>
<p>Product Name: Guaiacol<br />
Synonyms: 2-Methoxyphenol/Guaiacol; GAIACOL; 0-Methoxyphenol; 0-Hydroxyanisole; 2-Methoxyphenol; Catechol monomethyl ether; Guaiaco; 1-Hydroxy-2-methoxybenzene; a-methoxyphenolsalicyl methyl ether<br />
Assay: 99.5 Percent<br />
CAS No.: 90-05-1<br />
EINECS No.: 201-964-7<br />
Molecular Formula: C7H8O2<br />
Molecular Weight: 124.14<br />
Density: 1.129 g/mL at 25 Deg(lit.)<br />
Melting point: 26-29 Deg(lit.)<br />
Boiling point: 205 DEG(lit.)<br />
Flashing point: 82DEG<br />
Water Solubillity: 17 g/L (15 DEG)<br />
Appearance: Pale yellow transparent oily liquid<br />
Packing: 25kg/drum<br />
Application: Used in Pharmaceuticals, dye and spices intermediates</p>
<p><br />
Application:</p>
<p>Guaiacol is a naturally occurring organic compound with the formula C6H4(OH)(OCH3), discovered by Ascanio Sobrero[citation needed]. Although it is biosynthesized by a variety of organisms, this yellowish aromatic oil is usually derived from guaiacum or wood creosote. Samples darken upon exposure to air and light. Guaiacol is present in wood smoke, resulting from the pyrolysis of lignin. The compound contributes to the flavor of many compounds, e.g., roasted coffee.</p>
<p>Guaiacol is a precursor to various flavorants, such as eugenol and vanillin. Its derivatives are used medicinally as an expectorant, antiseptic, and local anesthetic. It also can be used as an indicator in chemical reactions that produce oxygen. When oxygen binds to it, the complex turns yellowish brown and absorbs light maximally at about 470 nm.</p>Hydroxyapatitehttp://www.derekclarke.com/services/hydroxyapatite/53
http://www.derekclarke.com/services/hydroxyapatite/53<p>Derek Clarke is a leading UK-based Supplier of Hydroxyapatite</p>
<p>&nbsp;</p>
<p>Hydroxyapatite: A major component and an essential ingredient of normal bone and teeth. Hydroxyapatite makes up bone mineral and the matrix of teeth. It is hydroxyapatite that gives bones and teeth their rigidity.</p>
<p>&nbsp;</p>
<p>Hydroxyapatite molecules can group together (crystalize) to form microscopic clumps. If these tiny crystals of hydroxyapatite are deposited by mistake in or around joints, they may cause inflammation of the joints and nearby tissues, such as tendons and ligaments, particularly causing rotator cuff problems in the shoulder. The inflammation caused by hydroxyapatite crystals has been referred to as hydroxyapatite crystal disease.</p>Vyndaqel 20 mg (tafamidis) soft capsuleshttp://www.derekclarke.com/services/vyndaqel-20-mg-tafamidis-soft-capsules/54
http://www.derekclarke.com/services/vyndaqel-20-mg-tafamidis-soft-capsules/54<p>Derek Clarke is a well-established supplier of <span style="font-family:calibri,sans-serif; font-size:11pt">Vyndaqel 20 mg (tafamidis) soft capsules</span></p>
<p>&nbsp;</p>
<p><strong>What Vyndaqel is and what it is used for</strong></p>
<p><br />
Vyndaqel contains the active substance tafamidis.<br />
Vyndaqel is a medicine which treats a disease called Transthyretin (TTR) amyloid polyneuropathy,<br />
also known as TTR familial amyloid polyneuropathy (TTR-FAP). TTR amyloid polyneuropathy is<br />
caused by a protein called TTR that does not work properly. TTR is an important protein that carries<br />
other substances, such as hormones, through the body.</p>
<p><br />
In patients with this disease, TTR breaks up and may form fibres called amyloid. Amyloid can build<br />
up around your nerves and in other places in your body, preventing them from working normally.<br />
Eventually, the amyloid causes the symptoms of this disease.</p>
<p><br />
Vyndaqel, can prevent TTR from breaking up and forming amyloid deposits. This medicine is used to<br />
treat adult patients with this disease whose nerves have been affected (people with symptomatic<br />
polyneuropathy).</p>
<p>&nbsp;</p>
<p><strong>What you need to know before you take Vyndaqel</strong></p>
<p>&nbsp;</p>
<p><strong>Do not take Vyndaqel:</strong></p>
<p>&nbsp;</p>
<p>If you are allergic to tafamidis or any of the other ingredients of this medicine( listed in section 6).</p>
<p>&nbsp;</p>
<p><strong>Warnings and precautions</strong></p>
<p>&nbsp;</p>
<p>Talk to your doctor, pharmacist or nurse before taking Vyndaqel</p>
<p>Women that can become pregnant should use birth control while taking Vyndaqel and should continue using birth control for one month after stopping treatment with Vyndaqel.</p>
<p>&nbsp;</p>
<p><strong>Children and adolescents</strong></p>
<p>&nbsp;</p>
<p>Children and adolescents do not have the symptoms of TTR amyloid polyneuropathy. Vyndaqel is<br />
therefore not used for children and adolescents.</p>
<p>&nbsp;</p>
<p><strong>Other medicines and Vyndaqel</strong></p>
<p>&nbsp;</p>
<p>Tell your doctor or pharmacist if you are taking, have recently taken or might take any other<br />
medicines..</p>
<p>&nbsp;</p>
<p><strong>Pregnancy and breast-feeding and fertility</strong></p>
<p><br />
&bull; You should not take Vyndaqel if you are pregnant or breast-feeding. Talk to your doctor or<br />
pharmacist if you are pregnant, think you may be pregnant, or plan to become pregnant.<br />
&bull; If you are able to become pregnant, you should use birth control during treatment and for<br />
one month after stopping treatment.</p>
<p>&nbsp;</p>
<p><strong>Driving and using machines</strong></p>
<p>&nbsp;</p>
<p>No studies on the effects of Vyndaqel on the ability to drive or use machines have been performed.</p>
<p>&nbsp;</p>
<p><strong>Vyndaqel contains sorbitol</strong></p>
<p>&nbsp;</p>
<p>If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicine.</p>
<p>&nbsp;</p>
<p>Derek Clarke, with more than 30 years experience as an exporter of both branded and generics medicines, is able to source and supply products, often unavailable through other sources, quickly and efficiently.</p>
<p><br />
For more information on our supplies of Avonex injection please contact us on</p>
<p><span style="color:black; font-family:open sans; font-size:10pt">e-mail : <a href="mailto:paresh@derekclarke.com">paresh@derekclarke.com</a></span></p>LYNPARZA 50mghttp://www.derekclarke.com/services/lynparza-50mg/55
http://www.derekclarke.com/services/lynparza-50mg/55<p>Derek Clarke is a well-established supplier of LYNPARZA 50mg</p>
<p><br />
Each hard capsule contains 50 mg of olaparib.</p>
<p>For the full list of excipients, see section 6.1.</p>
<p><br />
Lynparza is indicated as monotherapy for the maintenance treatment of adult patients with platinum-sensitive relapsed BRCA-mutated (germline and/or somatic) high grade serous epithelial ovarian, fallopian tube, or primary peritoneal cancer who are in response (complete response or partial response) to platinum-based chemotherapy.</p>
<p>&nbsp;</p>
<p>Treatment with Lynparza should be initiated and supervised by a physician experienced in the use of anticancer medicinal products.</p>
<p>&nbsp;</p>
<p>Patients must have confirmation of a breast cancer susceptibility gene (BRCA) mutation (either germline or tumour) before Lynparza treatment is initiated. BRCA mutation status should be determined by an experienced laboratory using a validated test method (see section 5.1).</p>
<p>There are limited data in patients with somatic BRCA-mutated tumours (see section 5.1).</p>
<p>Genetic counselling for patients with BRCA mutations should be performed according to local regulations</p>
<p><br />
Posology</p>
<p><br />
The recommended dose of Lynparza is 400 mg (eight capsules) taken twice daily, equivalent to a total daily dose of 800 mg.</p>
<p>Patients should start treatment with Lynparza no later than 8 weeks after completion of their final dose of the platinum-containing regimen.</p>
<p>It is recommended that treatment be continued until progression of the underlying disease. There are no data on retreatment with Lynparza following subsequent relapse (see section 5.1).</p>
<p><br />
Method of administration</p>
<p><br />
Lynparza is for oral use.</p>
<p>Due to the effect of food on olaparib absorption, patients should take Lynparza at least one hour after food, and refrain from eating preferably for up to 2 hours afterwards</p>
<p>&nbsp;</p>
<p>Derek Clarke, with more than 30 years experience as an exporter of both branded and generics medicines, is able to source and supply products, often unavailable through other sources, quickly and efficiently.</p>
<p><br />
For more information on our supplies of Avonex injection please contact us on</p>
<p>e-mail : <a href="mailto:paresh@derekclarke.com">paresh@derekclarke.com</a></p>27 sleep tips that will make you fall asleep in 7 minutes or lesshttp://www.derekclarke.com/services/27-sleep-tips-that-will-make-you-fall-asleep-in-7-minutes-or-less/56
http://www.derekclarke.com/services/27-sleep-tips-that-will-make-you-fall-asleep-in-7-minutes-or-less/56<p>Do you struggle to get to sleep at night? Or do you find yourself dropping off around midnight only to be wide awake at 2 or 3am? If this sounds all too familiar to you then you could be searching for tips to help you sleep better.</p>
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<p>Even if you usually sleep well, if you are a first time parent you might be struggling to get your baby to sleep through and need some tips for helping baby sleep through the night. As someone who can&rsquo;t function without a solid 7-8 hours of sleep every night, a new baby completely changes your life and finding a way to get them to sleep through feels like the holy grail!</p>
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<p>Lack of sleep can totally change your life and you could find yourself losing concentration at work, becoming short tempered and picking up every cough and cold that is going around the office. There&rsquo;s a reason sleep disturbance was<a href="https://www.psychologytoday.com/blog/dreaming-in-the-digital-age/201412/why-sleep-deprivation-is-torture" target="_blank"> used as torture</a>!</p>
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<p>We&rsquo;ve put together a list of tips to improve sleep &ndash; everything from getting your bedroom&rsquo;s temperature right to little tricks to help you stay asleep until morning. So if you&rsquo;re struggling with insomnia or struggling to get into a pattern while working night shifts, read on for some helpful advice and tips to sleep better.</p>
<p>to read the full artical please click <strong><a rel="nofollow" href="https://www.thesleepjudge.com/27-sleep-tips-that-will-make-you-fall-asleep-in-7-minutes-or-less/"><span style="color:#FF0000">HERE</span></a></strong></p>
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</div>
</div>What To Do If You Have Bed Bugshttp://www.derekclarke.com/services/what-to-do-if-you-have-bed-bugs/57
http://www.derekclarke.com/services/what-to-do-if-you-have-bed-bugs/57<p>&nbsp;</p>
<p>Protecting your home is the only thing you need to do if you have bed bugs. Bed bugs are known for their stubbornness. Once they latch onto a furniture or bed, they are soon to be found in other kinds of bedding, sofas, boxes, and clothing.</p>
<p><br />
Bed bugs can live for months without feeding, but research suggests they feed on human blood for up to 10 days at a stretch. This makes them extremely dormant. It&rsquo;s important to stay vigilant when dealing with bed bugs. They are known for their resilience when hiding in corners or under furniture.</p>
<p><br />
More importantly, avoid taking old furniture into your home without having cleaned it of dust and debris. This is one of the major causes of a bed bug infestation. Old mattresses, moist and damp bedspreads and furniture are breeding grounds for bed bugs. So if you visually inspect even a single bed bug in your room, it&rsquo;s time to take action.&nbsp;&nbsp;</p>
<p>&nbsp;</p>
<p>Check out the rest of th eartical <a rel="nofollow" href="https://www.jenreviews.com/bed-bugs/"><u><span style="color:#FF0000"><strong>HERE</strong></span></u></a></p>
<p>&nbsp;</p>