Revised text about a study of 670 survivors of Hodgkin lymphoma who have lived 10 or more years that found myocardial infarction and structural heart defects were the major contributors to the excess grade 3 to grade 5 cumulative burden in survivors.

Added text about the results of a study of 3,172 5-year survivors of childhood cancer who received 10 Gy or higher to the Circle of Willis and at age 45 years the cumulative incidence of stroke was 11.3% (cited El-Fayech et al. as reference 51).

Added text to state that the prefrail phenotype is characterized by having two of five characteristics (low muscle mass, self-reported exhaustion, low energy expenditure, slow walking speed, and weakness) and the frail phenotype is characterized by having three or more of these characteristics.

Added text about a Childhood Cancer Survivor Study that compared self-reported pulmonary outcomes and their impact on daily activities among 5-year cancer survivors and a sibling cohort noting that by age 45 years, the cumulative incidence of any pulmonary condition was 29.6% for survivors (cited Dietz et al. as reference 4).