Benzo[k]fluoranthene Quickview (CASRN 207-08-9)

Health assessment information on a chemical substance is included in IRIS only after a comprehensive review of toxicity data by U.S. EPA health scientists from several Program Offices, Regional Offices, and the Office of Research and Development.

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Carcinogenicity Assessment for Lifetime Exposure

B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals)

Weight-of-Evidence Narrative:

Based on no human data and sufficient data from animal bioassays. Benzo[k]fluoranthene produced tumors after lung implantation in mice and when administered with a promoting agent in skin-painting studies. Equivocal results have been found in a lung adenoma assay in mice. Benzo[k]fluoranthene is mutagenic in bacteria.

This may be a synopsis of the full weight-of-evidence narrative. See IRIS Summary.