The first issue of Hothead Paisan was released in 1991, published by Diane DiMassa's own imprint, Giant Ass Publishing. In later issues the subtitle "Homocidal Lesbian Terrorist" was added to the title. The comic features the character "Hothead Paisan" who wrecks violent vengence on all who cross her path, while living in a small apartment with her cat "Chicken". The title proved popular and many more issues followed throughout the 1990's and 2000's. Twenty one issues have been published, as well as a one shot issue featuring "Chicken".

The comic had been collected into several anthology books, all published by Cleis Press.