Description

The NHLBI is currently coordinating a multi-center, longitudinal epidemiologic study to explore the associations between risk factors relevant to Hispanic health (e.g. acculturation) and several chronic diseases to include a large focus on CVD. This project is called the Hispanic Communities Health Study – Study of Latinos (HCHS-SOL) and will study Hispanics of Cuban American, Mexican American, Puerto Rican American and Central/South American ethnicity between the ages of 18 and 74 years. The current application proposes an ancillary study to the HCHS-SOL to compare estimates of total energy derived from the 24 hr dietary recall and physical activity energy expenditure derived from accelerometer data compared to the gold standard biomarkers (Doubly Labeled Water [DLW] and indirect calorimetry data) in a subset of participants in the HCHS-SOL study.

This is an application for the University of North Carolina at Chapel Hill (UNC) to serve as the coordinating center for the SOLNAS Study. Approximately 476 participants (at the four study sites) will be selected with equal representation by gender, age (20-37 yrs, 38-55 yrs, 56-74 yrs), body mass index (BMI), and Hispanic sub-groups. Biomarkers will be measured for total and resting energy expenditure and total physical activity energy expenditure using the DLW method, indirect calorimetry, and accelerometry, as well as protein, sodium, sucrose, fructose and potassium expenditure from urinary recovery. Blood and urine specimens will be stored for biomarker studies to validate usual intake measures. Study data will be analyzed, and manuscripts will be prepared presenting the study results.

The SOLNAS coordinating center will provide operational and scientific coordination for the field centers to ensure that the research objectives of the study are met. Specific services provided by the coordinating center will include study design, statistical analysis, data management, quality control of SOLNAS data collected, in addition to assistance with reporting of findings.