by phil @ Elixa

Tue Jan 30 10:20:35 PST 2018

Check out Elixa’s Facebook page for the occasional, usually enlightening post about ways you can keep yourself optimally healthy, happy, and long-lived without pharmaceuticals and bad advice from uninformed medical professionals. Some topics we have covered and more to come. Please like and follow us! Methylene blue for fungus, dementia, depression, and more. Hydrogen peroxide (H2O2) […]

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by @ Articles - Articles

The oldest human recorded in modernity was Jeanne Louise Calment, she died
in the age of 122 years and 164 days
[1]
.

There are rumors that the oldest tortoise called Adwaita (Aldabra giant
tortoise) died in the age of about 250 years
[2]
or that it was 188-year-old radiated tortoise named Tui Malila
[3]
, or that the highest verified age of 177 years had Galapagos giant
tortoise Harriet
[4]
. The oldest currently living turtle is considered to be Jonathan
(Seychelles giant tortoise), estimated to be over 180 years old these days
[5]
. Although all aforementioned numbers are estimations, it seems these
turtles were older than human supercentenarians.

All previously mentioned species are terrestrial tortoises, a group with
longest lifespans among turtles. The most famous of them, well-researched
Galapagos giant tortoise, was observed by Charles Darwin when he was
forming his well-known theory of evolution by natural selection
[6]
. There is only one freshwater turtle known to be able to outlive human, it
is the common snapping turtle estimated to live up to more than hundred
years
[7]
. While being considerably less researched, recorded maximal lifespan of
sea turtles is usually shorter, not exceeding 80 years, however, it is
believed that the green sea turtle can live up to 100 years.
[8]

It is a difficult question to answer why these reptiles can outlive us
because even to determine the actual age of animals with a long lifespan is
complicated – partially due to the fact that it takes such a long time to
study. Furthermore, many turtles are endangered species
[9]
so there may not be as many organisms to hand as needed for proper
statistics. Nonetheless, we can still claim that turtles are among the most
long-living vertebrates on earth
[10]
. Why?

Firstly, turtles, like all reptiles, benefit from being ectothermic
organisms. They do not maintain body temperature and thus save a lot of
energy. But that also means they are less flexible: it is crucial for their
lifespan to be in natural temperature environment of daily cycles with
night-time temperature drop
[11]
. If they do not live under these conditions in captivity, metabolic
pathways change and turtles die much sooner.
[12]

Turtles are well-adapted in other ways: their famous shell – the carapace
–is good protection against natural predators. Most of hatchling turtles
with a soft shell do not survive the first year
[13]
. A research of natural populations of freshwater turtles showed that only
one per cent of them can celebrate the twentieth birthdays, but once the
adulthood is reached, mortality rate drops and remains constant throughout
the rest of life
[14]
.

Some turtles can survive under extreme environmental conditions, such as
freezing
[15]
or lack of oxygen for months
[16]
. They can even undergo hibernation and anaerobic metabolism and therefore
deal with hypoxia and anoxia, it was also proposed that the same genes can
play a role in longevity itself
[17]
and also in oxidative stress resistance
[18]
that further promotes longer life
[19]
.

Turtle’s bones and shell are used as lactate buffer lowering metabolic
acidosis caused by anaerobic glycolysis during the period of lack of oxygen
[20]
;
[21]
Their organism is protected by strong innate immunity compensating slow
acquired immune reactions
[22]
.

Because turtles have very slow metabolism as well as growth, their bodies
do not need to deal with excessive metabolic heat and byproducts as mammals
[23]
. Their natural diet is very simple but also necessary for their longevity.
[24]

According to the evolutionary theories, staying alive is less important
after menopause. Galapagos giant tortoises achieve sexual maturity late
(around the age of up to forty years in the wild, and between twenty and
twenty-five years of life in captivity
[25]
), then staying fertile until death
[26]
.

The Hayflick limit is said to determine how many times a cell can divide
[27]
. The Hayflick limit of Galapagos giant tortoise was said to be about 110
divisions
[28]
, approximately twice as many as 50 of human cells
[29]
. Studies in this context have highlighted the importance of telomeres, the
protective end sequences of chromosomes, that get shorter with each cell
division
[30]
, can play at least a partially role in life expectancy. It was observed
that telomeres in European freshwater turtle’s cells are of the same length
in both embryo and adult organism
[31]
.

Thus, it was believed that turtles are negligibly senescent organisms
[32]
. In other words, the cells do not age and no age-related diseases appear,
which is very different cell behavior than in human bodies
[33]
and probably the key to any natural longevity. However, evidence now
suggests that turtles may not be really negligibly senescent because of
observations of survival and reproductive senescence in late age in the
painted turtle population
[34]

As we can see, turtles have some advantages in the lifespan field. Some of
these might inspire researchers to increase lifespans in humans.

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Colloidal silver acts as a powerful, natural antimicrobial that kills most bacteria, viruses, and fungi. Used regularly, it helps prevent infections and lessens their severity and duration. Research at Rice University shows that ions of silver (not uncharged particles) suffocate pathogenic organisms by disabling the enzyme needed to use oxygen. Fortunately, silver ions have no negative effects on …

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by @ Articles - Articles

Tue Feb 21 13:06:47 PST 2012

The following is a quick overview on Cryonics.

NB: The information below is periodically reviewed for accuracy, but LongeCity makes no representations or gives any warranties whatsoever that the following information is accurate and complete at any point in time. LongeCity accepts no responsibility or liability for information contained on this page. The discussion of cryonics service providers and services in no way entails any endorsement on part of LongeCity. The lead author of this page, its editors and other contributors from time to time may be affiliated with one of the service providers mentioned below. Without qualification to the foregoing disclaimers, LongeCity strives to present the following information in an objective and balanced manner. If you feel that information on this page is inaccurate or imbalanced please contact the LongeCity Support Email.

Cryonics is based on the idea that future medicine will have capabilities well beyond those of current medicine, including the ability to cure all diseases, rejuvenate and repair damage incurred in the cryopreservation process — through the use of nanotechnology and other technologies. Cryonics can be an ambulance or time capsule to future medicine which can allow us to live many thousands of years or longer in youth and good health. Stored at very low temperatures there will be very little molecular motion in cryonics patients for tens of thousands of years, although most of us do not believe that we will have to wait anywhere near so long for future medicine.

Although cryonics patients must be legally dead before cryonics procedures to reduce or eliminate ischemic damage and ice formation can be applied, cryonicists do not believe that cryonics patients are dead in an ultimate sense. Nearly all the cells of the body are alive for quite some time after the heart stops — including neurons. A standby team can be used to minimize the time between pronouncement of death and cooling, cardiopulmonary support, etc. Cryonicists believe that the anatomical basis of mind can survive much longer than six minutes after stoppage of the heart in the absence of cooling — despite the inability of current medicine to revive patients without neurological damage after more than six minutes of cardiac arrest. (See Quantifying Ischemic Damage for Cryonics Rescue for more details.)

Existing Cryonics Organizations

For most of cryonics history (which began in the mid-1960s), all of the cryonics organizations offering cryonics services have been in the United States. In 2005 a cryonics organization was created in Russia (just northwest of Moscow) and there are plans for another cryonics organization in Australia to offer perfusion and storage of cryonics patients within a few years. LongeCity does not endorse any particular cryonics organization. The data below is taken from the cryonics organizations without LongeCity attempting to verify the accuracy of their claims or the extent of the services they claim to provide. If you are considering utilizing any of these organizations, you should conduct your own investigation.

Oregon Cryonics was incorporated in 2005, but accepted its first patient (a pet patient) in May, 2014. Jordan Sparks is the owner/operator, but he has plans for a Board of Directors or other mechanism to out-live him (to allow for the organization to continue).

Cryonics Services Offered

Not all cryonics services are offered by all cryonics organizations. Patient administration service is offered by cryonics organizations that sign-up Members who are to be cryopreserved upon legal death and maintain responsibility for those Members while they are Patient's in cryopreservation storage. Perfusion is the replacement of normal body fluid with cryoprotective solutions to reduce or prevent ice formation at cryogenic temperatures. Storage is the storage of a cryonics patient in liquid nitrogen. Standby/Stabilization/Transport (SST) involves standing by the bedside of a medically terminal patient destined to be cryopreserved, the application of a heart-lung resuscitator and ice-water cooling as soon as possible after declaration of death,and transport to a perfusion facility while tissues are still being stabilized at low temperature.

The following table represents the services which cryonics organizations say they provide.

NAME

PATIENT ADMINISTRATION

PERFUSION

STORAGE

SST

Alcor

Yes

Yes

Yes

Yes

ACS

Yes

Yes*

No*

Yes*

CI

Yes

Yes

Yes

No*

KrioRus

Yes

Yes

Yes

No

Oregon Cryonics

Yes

Yes

Yes

No

SA

No*

No

No

Yes

Trans Time

Yes

No

Yes

No

*=simplification, see explanation

All standby cases done for Alcor Foundation outside of Arizona, but inside the continental United States are handled by Suspended Animation, Inc (SA). Alcor does standby for Alcor Members who are terminal in Arizona, Hawaii, and Alaska as well as in Canada. SA does not provide SST services outside the continental United States for any organization.

The American Cryonics Society (ACS) states that it mainly contracts with Suspended Animation,Inc. (SA) for perfusion and standby/transport, and contracts with the Cryonics Institute (CI) for storage. ACS also states that it has equipment, contractors and volunteers which are available for use in perfusion and standby in California should the need arise, although this is far less sophisticated and formal than what SA provides. ACS creates and manages individual charitable trusts for its patients. ACS regards these trusts as an important feature of the benefit gained by being an ACS Member.

Cryonics Institute (CI) Members who reside in the continental United States have the option of contracting directly with SA if they desire professional SST.In some cases volunteers or paid funeral directors have provided these services to CI Members. SA will keep records of CI Members who have arranged to have SA SST, but does not continue any administrative responsibility after the patient has been cryopreserved.

Trans Time is currently storing patients, but (despite what their website says) is not currently seeking new Members or Patients.

Sizes of the Organizations

There are various ways by which organization size could be measured, but for the purposes of this section size is represented by the number of Members in the organization, the number of patients currently being stored in liquid nitrogen and the number of full-time paid staff in the organization. The figures below are for April 2017, and are based on the statements of the organization in question.

NAME

MEMBERS

FUNDED MEMBERS

PATIENTS

STAFF

Alcor

1,639*

1,132*

150

9*

ACS

?*

?*

20*

1*

CI

1,384*

?*

151*

3*

KrioRus

N/A

N/A

52

7*

Oregon Cryonics

8*

N/A

6

5*

SA

N/A

N/A

N/A

3*

Trans Time

?

?

3

1?

*=simplification, see explanation

The Membership statistics reported above are for living Members only. Both Alcor and CI patients are Members (except for the ACS patients at CI). The American Cryonics Society (ACS) has an organizational policy against publishing the number of Members it has in its organization. As of April 2017 the 20 ACS patients were all in storage at the Cryonics Institute (CI). ACS has had one part-time clerk to do office work and has otherwise relied on volunteers. Alcor has 9 full-time staff, 1 consultant, and 1 regular volunteer. The 151 patients in storage at CI includes 20 ACS patients. KrioRus has no Membership program, and the method of counting patients is odd — a few are not stored by KrioRus. KrioRus has 4 full-time and 3 part-time employees as well as numerous volunteers.

CI is a subcontractor for storage of 20 ACS patients. CI has three paid staff (two full-time and one part-time), a few contractors and many volunteers. Accounting is done by CI Treasurer Pat Heller (a CPA) with auditing by another CI Director. Trans Time does not report its Membership numbers. Suspended Animation (SA) is a subcontractor which provides Standby/Stabilization/Transport (SST) only to other cryonics organizations (ACS, Alcor and CI), so it has no Members or Patients — so the reporting of Members or Patients for SA is "Not Applicable" (N/A). SA makes extensive use of subcontractors when needed.

Alcor and CI member numbers are not directly comparable because the word "Member" has different meanings for the two organizations. Membership in CI provides the privilege of obtaining cryopreservation services: pet, DNA or human cryopreservation. Many join CI only to store DNA or pets or to support CI, including some Alcor Members. Some Alcor Members have even made arrangements to use CI as a "back-up". Alcor does not allow its Members to have Alcor as a "back-up". Prior to April, 2012, all Alcor Members had made arrangements (ie, funding and contracts in place) for human cryopreservation and SST, but in April 2012 the Associate Alcor Member program was introduced. Associate Alcor Members do not have any cryopreservation arrangements with Alcor.

ForApril 2017, Alcor reported 1,639 living Members, 1,132 of whom had made arrangements for human cryopreservation, and 357 of whom were Associate Members. Of the 1,384 CI Members in April 2017, 212 of those had made arrangements for both human cryopreservation and standby/stabilization/transport (all with SA). In September 2015, CI ceased reporting how many of it Members have funding and contracts for cryopreservation. Historically, less than half of CI Members have been funded (prior CI statistics). Since 2006, CI offers a 'partnership' arrangement for CI Members for SA SST.

As noted in the previous section, Trans Time is currently storing patients, but (despite what their website says) is not currently seeking new Members or Patients.

In 2011 and 2012 SA reorganized its staff to have more part-time employees and contractors, and for much of 2012 and 2013 SA was re-organizing to have facilities in both California and Florida.

Oregon Cryonics has an owner (Jordan Sparks) and four other full-time employees. OC has 9 Members, but is no longer accepting new Members..

The term neuropreservation (or "neuro") generally refers to the practice of cryopreserving only the head rather than the whole body. A "neuro" is usually a whole head, not just the brain, but sometimes only the brain is cryopreserved. Keeping the whole head to preserve the brain is convenient for both perfusion and storage (the skull protects the brain). In some cases, however, "neuros" are brain-only. The following represent options various organizations say that they offer.

NAME

WHOLE BODY

NEURO

Alcor

Yes

Yes

ACS

Yes

No*

CI

Yes

No

KrioRus

Yes

Yes

Oregon Cryonics

No

Yes

SA

N/A

N/A

Trans Time

Yes

Yes

*=simplification, see explanation

Alcor states that its Members have the option of having their whole body cryopreserved or only their head ("neuro") — with different fees applicable to each choice. In April 2017, Alcor reported having 93 neuro, 54 whole body, and 4 neuro+whole bodypatients, whereas KrioRus reported 25 neuro and 27 whole-body patients. Trans Time has one whole body and two brains.

All CI Members with human cryopreservation arrangments are "whole body". ACS states that it does not have a policy against neuropreservation, but as long as it only uses CI as its subcontract or for storage it cannot offer neuro-cryopreservation as an option. Suspended Animation (SA) is a subcontractor which provides Standby/Stabilization/Transport only to other cryonics organizations, not storage, so the question of storage options with SA is "Not Applicable" (N/A).

Oregon Cryonics only stores heads and brains. As of February, 2016 Oregon Cryonics was chemically preserving three human brains, and cryopreserving one dog brain.

Cryopreservation and Yearly Fees

Comparing fees for human cryopreservation and yearly Membership or Emergency Responsibility is difficult to summarize in table form because the policies, procedures and options between the cryonics organization are so different. A great deal of explanation is required. Note that the high prices for human cryopreservation are generally covered by life insurance policies. The following represent the fees that the following organizations state that they charge.

NAME

WHOLE BODY

NEURO

YEARLY FEES

Alcor

$200,000*

$80,000*

$620*

ACS

$155,000*

N/A

$376*

CI

$28,000*

N/A

$120*

KrioRus

$36,000*

$12,000

None

Oregon Cryonics

N/A

$25,000*

None

SA

N/A

N/A

None

Trans Time

$150,000

$50,000

$96*

*=simplification,see explanation

To Alcor's yearly fee of $620 annual dues, those living in the United States and Canada must add $180 yearly SST fees for a total of $800 per year. A lifetime payment plan is also available. SST service is not available to Alcor Members outside of the US and Canada, but a $15,000 surcharge is added to whole body and neuro prices in the United Kingdom, and a $25,000 surcharge is added to the prices paid by those living in other countries. For details on Alcor pricing, see Schedule A: Required Costs and Suspension Funding Minimums.

The prices given for the American Cryonics Society (ACS) are intended to reflect comparable service to what Alcor provides. In fact, ACS has a very wide menu of options and prices available, including reference to a "California Procedure" which is intended to be distinguished from the"Michigan Procedure" offered by the Cryonics Institute. The yearly fee for an ACS Member is $376 for the first four years and $300 per year thereafter. For details on ACS options and fees, see:www.americancryonics.org.

The Cryonics Institute (CI) charges $28,000 for perfusion and storage of a Lifetime Member and $35,000 for a Yearly Member. These prices do not include funeral director costs or shipment to CI for non-local cases. (When CI was begun it was imagined that every state would have at least one cryonics service provider.) The Lifetime CI Member has paid a one-time $1,250 fee and the Yearly CI Member has paid a $75 initiation fee and is paying a $120 yearly fee. Discounts for additional family members and underage family members apply only to Lifetime Memberships. For service more comparable to what Alcor provides — including Standby/Stabilization/Transport (SST) — a Lifetime Member pays $88,000 and a Yearly Member pays $95,000. For details on CI pricing see Membership andDetails Concerning SA Standby and Transport for CI Members.

For $49,000 KrioRus states that it offers Russians (Europeans?) the option of shipment and storage at the Cryonics Institute in the USA.

Oregon Cryonics charges $25,000 to cryopreserve a whole head, $18,000 for a brain with braincase, and $14,000 for a brain without the braincase. Oregon Cryonics will chemically preserve a brain for as little as $1,000 (see Oregon Cryonics Service Fees for details).

As noted in previous sections, Trans Time is currently storing patients, but (despite what their website says) is not currently seeking new Members or Patients.

Suspended Animation (SA) is a subcontractor which provides SST only to other cryonics organizations, not Membership or storage, so the question of these options with SA is "Not Applicable" (N/A).

Human Cryopreservation Procedures

Human cryopreservation procedures are much too complex to be summarized effectively here.

Alcor's procedures are summarized on a page of the Alcor website called Alcor Procedures. But is it also very helpful to read actual case reports of Alcor patients in the Cryopreservation Case Reports section of the Alcor website library.

CI has a summary of its procedures on its website calledGuide to Cryonics Procedures. CI procedures do not include Standby/Stabilization/Transport (SST), though CI will advise Members on obtaining assistance through local funeral directors. CI Members residing in the continental United States who wish to obtain SST can do so by subcontracting with Suspended Animation, Inc. (SA).

Although the American Cryonics Society (ACS) has equipment and volunteers which could be used if necessary, ACS basically relies on SA for Standby/Transport and CI for Perfusion/Storage.The human cryopreservation procedures of Trans Time and KrioRus are not documented on their websites.

Funding Cryonics by Insurance
The cost of cryonics is many thousands of dollars, but most cryonicists cover these costs with life insurance policies that name a cryonics organization as beneficiary. Premiums of life insurance policies are most affordable for those who are young and healthy. It is not prudent to seek life insurance in old age or after a terminal illness (when life insurance may be unobtainable). Nor is it prudent to believe that cryonics arrangements can be made efficiently or successfully when in a terminal condition.

Rudi Hoffman sells the great majority of cryonics life insurance policies. It makes good sense to take advantage of Rudi's considerable expertise in matters of cryonics and life insurance. (A sincere and unpaid plug for Rudi.)

by @ ImmInst Active Topics

Sun Feb 11 17:35:26 PST 2018

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by phil @ Elixa

Mon Oct 03 13:31:40 PDT 2016

http://www.absoluteastronomy.com/topics/Colloidal_silver The medical uses of silver include its incorporation into wound dressings to treat external infections, and its use as anantiseptic and disinfectant in medical appliances. Silver is also promoted within alternative medicine in the form of colloidal silver, although it has not been proven to be safe or effective. The silver ion (Ag+) is bioactive and in sufficient concentration readily kills […]

by @ Articles

The oldest human recorded in modernity was Jeanne Louise Calment, she died
in the age of 122 years and 164 days
[1]
.

There are rumors that the oldest tortoise called Adwaita (Aldabra giant
tortoise) died in the age of about 250 years
[2]
or that it was 188-year-old radiated tortoise named Tui Malila
[3]
, or that the highest verified age of 177 years had Galapagos giant
tortoise Harriet
[4]
. The oldest currently living turtle is considered to be Jonathan
(Seychelles giant tortoise), estimated to be over 180 years old these days
[5]
. Although all aforementioned numbers are estimations, it seems these
turtles were older than human supercentenarians.

All previously mentioned species are terrestrial tortoises, a group with
longest lifespans among turtles. The most famous of them, well-researched
Galapagos giant tortoise, was observed by Charles Darwin when he was
forming his well-known theory of evolution by natural selection
[6]
. There is only one freshwater turtle known to be able to outlive human, it
is the common snapping turtle estimated to live up to more than hundred
years
[7]
. While being considerably less researched, recorded maximal lifespan of
sea turtles is usually shorter, not exceeding 80 years, however, it is
believed that the green sea turtle can live up to 100 years.
[8]

It is a difficult question to answer why these reptiles can outlive us
because even to determine the actual age of animals with a long lifespan is
complicated – partially due to the fact that it takes such a long time to
study. Furthermore, many turtles are endangered species
[9]
so there may not be as many organisms to hand as needed for proper
statistics. Nonetheless, we can still claim that turtles are among the most
long-living vertebrates on earth
[10]
. Why?

Firstly, turtles, like all reptiles, benefit from being ectothermic
organisms. They do not maintain body temperature and thus save a lot of
energy. But that also means they are less flexible: it is crucial for their
lifespan to be in natural temperature environment of daily cycles with
night-time temperature drop
[11]
. If they do not live under these conditions in captivity, metabolic
pathways change and turtles die much sooner.
[12]

Turtles are well-adapted in other ways: their famous shell – the carapace
–is good protection against natural predators. Most of hatchling turtles
with a soft shell do not survive the first year
[13]
. A research of natural populations of freshwater turtles showed that only
one per cent of them can celebrate the twentieth birthdays, but once the
adulthood is reached, mortality rate drops and remains constant throughout
the rest of life
[14]
.

Some turtles can survive under extreme environmental conditions, such as
freezing
[15]
or lack of oxygen for months
[16]
. They can even undergo hibernation and anaerobic metabolism and therefore
deal with hypoxia and anoxia, it was also proposed that the same genes can
play a role in longevity itself
[17]
and also in oxidative stress resistance
[18]
that further promotes longer life
[19]
.

Turtle’s bones and shell are used as lactate buffer lowering metabolic
acidosis caused by anaerobic glycolysis during the period of lack of oxygen
[20]
;
[21]
Their organism is protected by strong innate immunity compensating slow
acquired immune reactions
[22]
.

Because turtles have very slow metabolism as well as growth, their bodies
do not need to deal with excessive metabolic heat and byproducts as mammals
[23]
. Their natural diet is very simple but also necessary for their longevity.
[24]

According to the evolutionary theories, staying alive is less important
after menopause. Galapagos giant tortoises achieve sexual maturity late
(around the age of up to forty years in the wild, and between twenty and
twenty-five years of life in captivity
[25]
), then staying fertile until death
[26]
.

The Hayflick limit is said to determine how many times a cell can divide
[27]
. The Hayflick limit of Galapagos giant tortoise was said to be about 110
divisions
[28]
, approximately twice as many as 50 of human cells
[29]
. Studies in this context have highlighted the importance of telomeres, the
protective end sequences of chromosomes, that get shorter with each cell
division
[30]
, can play at least a partially role in life expectancy. It was observed
that telomeres in European freshwater turtle’s cells are of the same length
in both embryo and adult organism
[31]
.

Thus, it was believed that turtles are negligibly senescent organisms
[32]
. In other words, the cells do not age and no age-related diseases appear,
which is very different cell behavior than in human bodies
[33]
and probably the key to any natural longevity. However, evidence now
suggests that turtles may not be really negligibly senescent because of
observations of survival and reproductive senescence in late age in the
painted turtle population
[34]

As we can see, turtles have some advantages in the lifespan field. Some of
these might inspire researchers to increase lifespans in humans.

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by phil @ Elixa

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