Comment by Carlos Morra

ONSET OF CLINICAL ACTION OF ANTIDEPRESSANTS

Carlos Morra’s comment on Donald Klein’s comment on Martin M. Katz’s essay on the “Onset of clinical action of antidepressants”

I noted that Dr. Klein found that in his re-analysis of Dr. Katz’s data the onset of antidepressant action was not established until the second or third week of treatment. The findings in his re-analysis differ also from Professor Kasper’s, who found statistically significant change in the total score of the Hamilton Depression Scale during the first week (Kasper et a 2006) and suggested that antidepressant action can be seen during the 24 hours after the first dose.