Covering the whole development process for the global biotechnology industry

Bioprocessing begins upstream, most often with culturing of animal or microbial cells in a range of vessel types (such as bags or stirred tanks) using different controlled feeding, aerating, and process strategies.

Beginning with harvest of material from a bioreactor, downstream processing removes or reduces contaminants to acceptable levels through several steps that typically include centrifugation, filtration, and/or chromatographic technologies.

Drug products combine active pharmaceutical ingredients with excipients in a final formulation for delivery to patients in liquid or lyophilized (freeze-dried) packaged forms — with the latter requiring reconstitution in the clinical setting.

Many technologies are used to characterize biological products, manufacturing processes, and raw materials. The number of options and applications is growing every day — with quality by design (QbD) giving impetus to this expansion.

Even as it matures, the biopharmaceutical industry is still a highly entrepreneurial one. Partnerships of many kinds — from outsourcing to licensing agreements to consultancies — help companies navigate this increasingly global business environment.

Tuesday, July 11, 2017 Daily Archives

Today, Refine Technology, most known for developing the award winning ATF™ System for cell perfusion, announced distribution arrangements with three companies to help promote and sell its new CleanLine™ 1.5” Single Use Connector on the east coast. Refine Technology has partnered with Triangle Process Equipment in Wilson, NC, Accuflow Systems in Frederick, MD and Casella Process Systems in Barrington, NH to help develop the market for improved high volume, low shear sterile fluid flow rates in single use bioprocessing. “We…