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A group of survivors, originally trapped together in a superstore by a series of escalating disasters, has split in two -- one group heading to Denver airport on a repaired school bus, the other remaining in the Sanctuary trying to rebuild the community they lost. But the world outside is dark and filled with dangerous chemicals that turn people into bloodthirsty monsters.

The situation grows more dire in a town where poisonous chemicals have been released. Some of the kids trapped in a superstore decide to go for help, while others try to ride out the storm inside. Both face a unique set of challenges in surviving.