These results revealed a novel role of DDB in H3K56Ac deacetylation during early step of NER (show NR1H2 ELISA Kits) and the existence of active functional cross-talk between DDB-mediated damage recognition and H3K56Ac deacetylation.

The identification of Vpr mutants which associate with DCAF1 but only poorly with DDB1 suggests that DCAF1 is necessary but is not sufficient for the Vpr association with DDB1-containing E3 ligase complex.

Caenorhabditis elegans DDB-1 is required for the degradation of CDT-1 (show CDT1 ELISA Kits) during S phase. DDB-1 interacts specifically with CUL-4 but not with other C. elegans cullins.

Data show that SKN-1 protein levels, nuclear accumulation, and activity are repressed by the WD40 repeat protein WDR-23, which interacts with the CUL-4/DDB-1ubiquitin ligase to presumably target the transcription factor for proteasomal degradation.

DDB1 Antigen Profile

Antigen Summary

The protein encoded by this gene is the large subunit (p127) of the heterodimeric DNA damage-binding (DDB) complex while another protein (p48) forms the small subunit. This protein complex functions in nucleotide-excision repair and binds to DNA following UV damage. Defective activity of this complex causes the repair defect in patients with xeroderma pigmentosum complementation group E (XPE) - an autosomal recessive disorder characterized by photosensitivity and early onset of carcinomas. However, it remains for mutation analysis to demonstrate whether the defect in XPE patients is in this gene or the gene encoding the small subunit. In addition, Best vitelliform mascular dystrophy is mapped to the same region as this gene on 11q, but no sequence alternations of this gene are demonstrated in Best disease patients. The protein encoded by this gene also functions as an adaptor molecule for the cullin 4 (CUL4) ubiquitin E3 ligase complex by facilitating the binding of substrates to this complex and the ubiquitination of proteins.