The joint US/UK study on vitamin D and dementia (Littlejohns et al, 2014) is
interesting and has already propagated through popular web news channels.
However, it needs to be interpreted very conservatively for at least two reasons.
One reason is that APOE genotype of the subjects has not been considered. This
is important because APOE gene polymorphisms are the major known risk factors
for Alzheimer's and APOE expression appears to be regulated by vitamin D
analogues (Wu-Wong et al., 2007). The second reason is a lack of any
intervention. &quot;Further studies are necessary&quot; sounds self-serving and is not the
conclusion that justifies the expense..

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