Conclusions :
In these studies, we use innovative, cellular-level resolution in vivo imaging combined with additional functional tests to characterize age-related changes in the structure and function of cells of the PRC-NVU in four cohorts of mice with the genetic defects, and in corresponding controls. Our ability to follow degeneration in vivo using imaging methods and automated image analysis allows a drastic reduction in the number of animals needed for these experiments, and permits fast analysis of correlative, local changes in structure and function.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.