The ectopic overexpression of miR-379 inhibited cell migration, invasion and EMT progress, while downregulated miR-379 reversed the effect. In addition, miR-379 regulated the focal adhesion kinase (FAK) by directly binding to its 3'-UTR, resulting in suppression of AKT signaling. In clinical samples of gastric cancer (GC), miR-379 inversely correlated with FAK, which was upregulated in GC.

evidence that despite the fact that FAK is in the active, open conformation at CAs (显示 CSE1L 抗体), its kinase activity is dispensable for ciliogenesis and ciliary function revealing that FAK plays a scaffolding role in multiciliated cells.

FAK is required for external force-induced spindle reorientation, suggesting that FAK's involvement in this process stems from a role in the transduction of external forces to the cell cortex.

FAK is required for tension-dependent organization of collective cell movements in Xenopus mesendoderm.

work identifies new roles for the FERM domain in the regulation of the dynamics of FAK on its signaling complexes in vivo and in vitro and identifies epiboly as the earliest developmental process in which FAK plays a crucial role during development

These data suggest an important role for the FERM domain in the activation of FAK.

FAK phosphorylation at Y861 is essential for lamellipodial protrusion induced by BDNF (显示 BDNF 抗体), while phosphorylation at Y925 controls the rate of point contact turnover.

Data imply that FAK plays an essential role in chamber outgrowth and looping morphogenesis.

FAK is required for proper topographic positioning of retinal axons along the anterior-posterior axis of the optic tectum in Xenopus and zebrafish, a guidance decision mediated in part by A-type ephrins.

Fak56 may play a subtle role in the negative regulation of integrin adhesion

Fak56D mutation causes severe disruption of the optic stalk structure. These phenotypes were completely rescued by Fak56D transgene expression in the SG cells but not in photoreceptor cells.

An intron loss of Dfak gene in species of the Drosophila melanogaster subgroup.

Together these findings suggest that modulation of Fak56 function is important for action potential propagation and Ca2 (显示 CA2 抗体)+-regulated neuromuscular transmission in vivo.

Data show that Fak56 is required to restrict larval neuromuscular junctions (NMJ)growth during NMJ development and mediates an extracellular signal through the integrin receptor.

FAK (PTK2) 抗原简介

Antigen Summary

This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene, but the full-length natures of only three of them have been determined.