Lenti-MART-1(DMF5) CAR (scFv-28εRIγ, Melan-A)-VP(VP-CAR-LC332)

The ready-to-use lentiviral particles of Lenti-MART-1(DMF5) CAR (scFv-28εRIγ, Melan-A)-VP is packaged using 3rd generation of lentiviral packaging system, in which the gene of CAR will be driven by a CMV promotor. The target gene of scFv (Melan-A)-CD28-FcεRIγ packaged in lentiviral particles could be used for high efficency tranduction of T cells and stably integrated expression.

Specifications

Type of Therapeutics

Chimeric Antigen Receptor

Target

MART-1(DMF5)

Expression Cassette

scFv (Melan-A)-CD28-FcεRIγ

Clone

Melan-A

Promotor

CMV

Packaging System

Lentivirus

Packaging Cell

293T

Targeting Diseases

Metastatic melanoma

Target

Introduction

Protein melan-A also known as melanoma antigen recognized by T cells 1 or MART-1 is a protein that in humans is encoded by the MLANA gene. A fragment of the protein, usually consisting of the nine amino acids 27 to 35, is bound by MHC class I complexes which present it to T cells of the immune system. These complexes can be found on the surface of melanoma cells. Decameric peptides (26-35) are being investigated as cancer vaccines.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.