Previous HGNC Symbols for GRIK5 Gene

Previous GeneCards Identifiers for GRIK5 Gene

Summaries for GRIK5 Gene

Entrez Gene Summary for GRIK5 Gene

This gene encodes a protein that belongs to the glutamate-gated ionic channel family. Glutamate functions as the major excitatory neurotransmitter in the central nervous system through activation of ligand-gated ion channels and G protein-coupled membrane receptors. The protein encoded by this gene forms functional heteromeric kainate-preferring ionic channels with the subunits encoded by related gene family members. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

UniProtKB/Swiss-Prot for GRIK5 Gene

Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds kainate > quisqualate > domoate > L-glutamate >> AMPA >> NMDA = 1S,3R-ACPD.

Tocris Summary for GRIK5 Gene

Kainate receptors are members of the ionotropic class of glutamate receptors, which also includes NMDA and AMPA receptors. Kainate receptors have been identified both pre- and post-synaptically. They contribute to excitatory postsynaptic currents in many regions of the CNS.

Protein details for GRIK5 Gene (UniProtKB/Swiss-Prot)

Protein attributes for GRIK5 Gene

Size:

980 amino acids

Molecular mass:

109265 Da

Quaternary structure:

Tetramer of two or more different subunits. Associates with GRIK1 (both edited and unedited versions), GRIK2, or GRIK3 to form functional channels. Homomeric associations do not produce any channel activity (By similarity).

Molecular function for GRIK5 Gene

Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds kainate > quisqualate > domoate > L-glutamate >> AMPA >> NMDA = 1S,3R-ACPD.

Primer Products

No data available for
Protein differential expression in normal tissues ,
mRNA Expression by UniProt/SwissProt and
Phenotype-based relationships between genes and organs from Gene ORGANizer
for GRIK5 Gene

No data available for
UniProtKB/Swiss-Prot and
Genatlas
for GRIK5 Gene

Publications for GRIK5 Gene

Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.(PMID: 19086053)Gratacòs M … Psychiatric Genetics Network Group(American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2009)3224560

The genes encoding the glutamate receptor subunits KA1 and KA2 (GRIK4 and GRIK5) are located on separate chromosomes in human, mouse, and rat.(PMID: 7527545)Szpirer C … Copeland NG(Proceedings of the National Academy of Sciences of the United States of America 1994)232260