Volume 3.44 | Nov 25

Team Science for Turner Syndrome
Investigators found that a mutation in the UTX gene triggers a deficiency in a particular kind of immune cell that is needed to fight infections. Turner patients have such an immune cell deficiency. The discovery shows the biological mechanisms behind chronic recurrent infections and points to a potential target to alleviate them. [Press release from University of North Carolina at Chapel Hill School of Medicine discussing publication in Immunity] Press Release|Full Article|Graphical Abstract

STING: Infection, Inflammation and Cancer
The discovery of the STING (stimulator of interferon genes)-controlled innate immune pathway, which mediates cytosolic DNA-induced signaling events, has recently provided important insights into these processes, opening the way for the development of novel immunization regimes, as well as therapies to treat autoinflammatory disease and cancer. [Nat Rev Immunol] Abstract

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