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Magnus remained on the station, replacing Expedition 17/18 Flight Engineer Gregory E. Chamitoff, who returned to Earth with the STS-126 crew. Magnus will serve as a flight engineer and NASA science officer for Expedition 18. Magnus will return to Earth on shuttle mission STS-119.

Endeavour carried a reusable logistics module that held supplies and equipment, including additional crew quarters, additional exercise equipment, equipment for the regenerative life support system and spare hardware.

STS-126 was the 27th shuttle mission to the International Space Station.