C-H Bond Catalytic Oxidation at Low Temperature

The Carbon-Hydrogen (C-H) Bond is a generally unreactive connection found in many widely used chemicals. Being able to split or activate these bonds, connecting them with other functional groups, has practical applications in chemical synthesis of pharmaceuticals, and could replace petrochemicals with less expensive alkanes. Most of these activation processes require extreme conditions, like high temperatures, strong oxidants, or high acidity, which limit their application.

Researchers at Purdue University have developed a new methodology for efficiently catalytic oxidation of C-H bonds at low temperatures. Using Chromium catalysts, oxidation of C-H bonds in hydrocarbons and ethers at -40 degrees C. is possible with minimal waste, even in industrial applications. Oxidation can also be achieved in the presence of olefins without affecting these materials. The yields for this reaction are also higher than existing techniques resulting in reactions that are more selective, milder, and produce more of the desired chemical.