Description:
D-Mannose is a naturally occurring simple sugar that
ismetabolized only in small amounts by the body, withthe remainder being rapidly excreted with the urine.In the urinary tract, D-Mannose interferes with particleattachment and allows everything to be flushed out inthe urine ...

Description:
Curcumin from turmeric supports healthy inflammatory response through
an array of complex biochemical mechanisms. Because curcumin is difficult to absorb, Turmeric With Meriva® uses a specialized extract combined with phosphatidylcholine to help generate greater cucumin bioavailability than common turmeric ...

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This scientific independent research is provided by Aisle7 and is for informational use only. GNC provides this information as a service but does not endorse it. Likewise, Aisle7 does not recommend or endorse any specific products.

For an herb, supported by traditional use but minimal or no scientific evidence. For a supplement, little scientific support.

Our proprietary "Star-Rating" system was developed to help you easily understand the amount of scientific support behind each supplement in relation to a specific health condition. While there is no way to predict whether a vitamin, mineral, or herb will successfully treat or prevent associated health conditions, our unique ratings tell you how well these supplements are understood by the medical community, and whether studies have found them to be effective for other people.

For over a decade, our team has combed through thousands of research articles published in reputable journals. To help you make educated decisions, and to better understand controversial or confusing supplements, our medical experts have digested the science into these three easy-to-follow ratings. We hope this provides you with a helpful resource to make informed decisions towards your health and well-being.

This supplement has been used in connection with the following health conditions:

Dose: 80 mg anthocyanins, the equivalent of approximately 100-120 cherries, 16-24 ounces tart cherry juice blend, 1 ounce of liquid concentrate, or 400 mg of concentrate in tablets or capsules
In a preliminary trial, people with osteoarthritis who took tart cherry extract for three months reported reduced joint tenderness and less joint pain and disability.
(more)

Dose: 8-12 ounces twice daily of a tart cherry juice product equivalent to at least 80 mg per day of anthocyanins or 100-120 cherries daily
Anthocyanins in tart cherry may support faster muscle recovery in athletes.
(more)

Dose: 8-12 ounces twice daily of a tart cherry juice product equivalent to at least 80 mg per day of anthocyanins or 100-120 cherries daily
Anthocyanins in tart cherry may support faster muscle recovery in athletes.
(more)

Dose: 1-8 ounces up to twice daily for seven days
Tart cherries contain a small amount of the sleep-regulating hormone melatonin.1 In a double-blind trial, healthy young people took one ounce daily of a tart cherry juice concentrate, estimated to contain the equivalent of 90-100 tart cherries, for seven days, which resulted in increased urine levels of melatonin and improvement in several measures of sleep quality.2 In a double-blind study of older people with insomnia, drinking eight ounces twice daily of a cherry-apple juice blend [note: ratio not given], estimated to be equivalent to 100 cherries per day, for seven days resulted in small improvements in some measures of sleep quality.3

Dose: 80 mg anthocyanins, the equivalent of approximately 100-120 cherries, 16-24 ounces tart cherry juice blend, 1 ounce of liquid concentrate, or 400 mg of concentrate in tablets or capsules
Tart cherries contain anthocyanins and other flavonoids that have anti-inflammatory effects according to test tube and animal studies.1, 2, 3 In a preliminary human trial, people with osteoarthritis who took 400 mg per day of tart cherry extract (supplying 100 mg per day of anthocyanins) for three months had reduced joint tenderness and reported less joint pain and disability.4 Double-blind research is needed to confirm these promising results.

Dose: Refer to label instructionsIn 1950, a doctor reported that daily consumption of one-half pound of black, sweet yellow, or red sour cherries (or an equivalent amount of cherry juice) seemed to prevent recurrences of gout attacks in patients with gout.1 More recently, a group of doctors reviewed the records of 24 gout patients who had taken 1 tablespoon of tart cherry juice concentrate twice a day for at least 4 months. Among those patients, the average number of gout attacks fell by 71%.2, 3 It is not known how cherries work against gout, but thought to be due to an anti-inflammatory effect.

Dose: 80 mg anthocyanins, the equivalent of approximately 100-120 cherries, 16-24 ounces tart cherry juice blend, 1 ounce of liquid concentrate, or 400 mg of concentrate in tablets or capsules
An animal study found reduced blood measures of muscle damage after strenuous exercise when the animals were fed tart cherry juice prior to exercise.1 In a small, double-blind study, young men drank 12 ounces twice daily of tart cherry juice blended with apple juice, [note: ratio not given] equivalent to 80 mg per day of anthocyanins or 100-120 cherries per day. After eight days the men performed intense elbow flexion exercises, and after drinking tart cherry juice this exercise resulted in less muscle pain and loss of strength compared to after drinking a placebo juice.2 In a small double-blind study, trained athletes took about one ounce twice daily of a tart cherry juice concentrate, containing about 550 mg per day of anthocyanin, for ten days beginning seven days before an intense session of weight-training leg exercises. Compared to when they took a placebo concentrate, taking tart cherry concentrate resulted in faster recovery of leg muscle strength after the exercise.3 Two double-blind trials investigated the effects of tart cherry juice in long distance runners. In one small double-blind trial,4 drinking eight ounces twice daily of tart cherry juice blended with apple juice, [note: ratio not given] equivalent to 80 mg per day of anthocyanins or 100-120 cherries per day, for eight days beginning five days before a marathon resulted in faster recovery of leg muscle strength and smaller elevations in post-race blood measures of inflammation. However, there was no difference in muscle soreness or in post-race blood measures of muscle damage. In another, larger double-blind trial,5 long distance runners who drank 10.5 ounces twice daily of tart cherry juice blended with apple juice, [note: ratio not given] equivalent to 80 mg per day of anthocyanins or 100-120 cherries per day, for eight days beginning one week before the race reported only one-third as much post-race muscle pain compared to those who used a placebo juice.

Dose: 80 mg anthocyanins, the equivalent of approximately 100-120 cherries, 16-24 ounces tart cherry juice blend, 1 ounce of liquid concentrate, or 400 mg of concentrate in tablets or capsules
Tart cherries contain antioxidants and anti-inflammatory substances that may reduce muscle pain,1, 2 and double-blind research in athletes has shown pain-reducing properties of tart cherry preparations.3, 4 In a small double-blind study, women with fibromyalgia drank 10.5 ounces twice daily of either tart cherry juice (equivalent to 100 to 120 cherries or 80 mg of anthocyanins per day) or a placebo juice for ten days prior to performing a session of intense elbow flexion exercise. While about one-third of the women reported significantly less elbow muscle pain when using tart cherry juice before exercise, the average effect in the overall group was no better than with the placebo.5

Dose: 8-12 ounces twice daily of a tart cherry juice product equivalent to at least 80 mg per day of anthocyanins or 100-120 cherries daily
An animal study found reduced blood measures of muscle damage after strenuous exercise when the animals were fed tart cherry juice prior to exercise.1 In a small, double-blind study, young men drank 12 ounces twice daily of tart cherry juice blended with apple juice [note: ratio not given in study], equivalent to 80 mg per day of anthocyanins or 100 to 120 cherries per day. After eight days the men performed intense elbow flexion exercises, and after drinking tart cherry juice this exercise resulted in less muscle pain and loss of strength compared to after drinking a placebo juice.2 In a small double-blind study, trained athletes took about one ounce twice daily of a tart cherry juice concentrate, containing about 550 mg per day of anthocyanin, for ten days beginning seven days before an intense session of weight-training leg exercises. Compared to when they took a placebo concentrate, taking tart cherry concentrate resulted in faster recovery of leg muscle strength after the exercise.3 Two double-blind trials investigated the effects of tart cherry juice in long distance runners. In one small double-blind trial,4 drinking eight ounces twice daily of tart cherry juice blended with apple juice, [note: ratio not given] equivalent to 80 mg per day of anthocyanins or 100 to 120 cherries per day, for eight days beginning five days before a marathon resulted in faster recovery of leg muscle strength and smaller elevations in post-race blood measures of inflammation. However, there was no difference in muscle soreness or in post-race blood measures of muscle damage. In another, larger double-blind trial,5 long distance runners who drank 10.5 ounces twice daily of tart cherry juice blended with apple juice, [note: ratio not given] equivalent to 80 mg per day of anthocyanins or 100 to 120 cherries per day, for eight days beginning one week before the race reported only one-third as much post-race muscle pain compared to those who used a placebo juice.

Dose: 8-12 ounces twice daily of a tart cherry juice product equivalent to at least 80 mg per day of anthocyanins or 100-120 cherries daily
An animal study found reduced blood measures of muscle damage after strenuous exercise when the animals were fed tart cherry juice prior to exercise.1 In a small, double-blind study, young men drank 12 ounces twice daily of tart cherry juice blended with apple juice [note: ratio not given in study], equivalent to 80 mg per day of anthocyanins or 100 to 120 cherries per day. After eight days the men performed intense elbow flexion exercises, and after drinking tart cherry juice this exercise resulted in less muscle pain and loss of strength compared to after drinking a placebo juice.2 In a small double-blind study, trained athletes took about one ounce twice daily of a tart cherry juice concentrate, containing about 550 mg per day of anthocyanin, for ten days beginning seven days before an intense session of weight-training leg exercises. Compared to when they took a placebo concentrate, taking tart cherry concentrate resulted in faster recovery of leg muscle strength after the exercise.3 Two double-blind trials investigated the effects of tart cherry juice in long distance runners. In one small double-blind trial,4 drinking eight ounces twice daily of tart cherry juice blended with apple juice, [note: ratio not given] equivalent to 80 mg per day of anthocyanins or 100 to 120 cherries per day, for eight days beginning five days before a marathon resulted in faster recovery of leg muscle strength and smaller elevations in post-race blood measures of inflammation. However, there was no difference in muscle soreness or in post-race blood measures of muscle damage. In another, larger double-blind trial,5 long distance runners who drank 10.5 ounces twice daily of tart cherry juice blended with apple juice, [note: ratio not given] equivalent to 80 mg per day of anthocyanins or 100 to 120 cherries per day, for eight days beginning one week before the race reported only one-third as much post-race muscle pain compared to those who used a placebo juice.

Tart or sour cherry is a variety of cherry grown worldwide that is often used in cooking and in making fruit syrups and other concentrates.1, 2 Tart cherries are especially high in anthocyanins, a type of flavonoid with strong antioxidant activity demonstrated in both test tube and double-blind human studies.3, 4 These and other flavonoids found in tart cherries have also been shown to have anti-inflammatory effects in test tube and animal studies.

Tart cherries are most popular as a food in Europe and Russia. Tart cherry juice and concentrate are available as supplements in North America.5, 6

Parts Used & Where Grown

Tart or sour cherry is a variety of cherry grown worldwide that is often used in cooking and in making fruit syrups and other concentrates.7, 8 Tart cherry juice and concentrate are available as supplements in North America.

The information presented by Healthnotes is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. Self-treatment is not recommended for life-threatening conditions that require medical treatment under a doctor's care. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires June 2017.