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Obesity, by far the most prevalent trigger of IR, is accompanied by a low-grade, chronic inflammatory response in the circulation and inside of metabolic organs. Proinflammatory cytokines secreted by recruited and resident macrophages in adipose t read more...

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In this kind of a scenario, muscle and adipose tissue uptake less glucose in the blood just after a meal, and hepatocytes inappropriately generate glucose through gluconeogenesis and glycogenolysis. This manifests as postprandial and fasting hyper read more...