Tumors (RECIST) ( 14 ). Patients were selected for MTT initiation with either everolimus or sunitinib after central assessment of cross-sectional imaging. The selection of first-line MTT therapy was based on international guidelines, but also on the

2 (HER2) negative. Presence of ≥1 measurable or evaluable lesion according to RECIST 1.1 was required. Bone metastases were allowed to be considered as target lesions in case of enhancement on scintigraphy, cytologic/histologic evidence or typical

absence of limiting toxicity, a dose escalation of etoposide could be proposed from cycle 2. Efficacy was assessed by CT scan every three cycles. Objective responses that did not meet the Response Evaluation Criteria In Solid Tumors (RECIST) criteria were

post-operative calcitonin at 3 and 6 months, and yearly after the first surgery were evaluated and used to classify patients into three groups: remission, stable disease and progressive disease. According to RECIST criteria and calcitonin doubling time