Eicosapentaenoic acid (EPA), a neuroactive omega-3 fatty acid, has been demonstrated to exert neuroprotective effects in experimental models of Parkinson's disease (PD), but the cellular mechanisms of protection are unknown. Here, we studied the effects of EPA in fully differentiated human SH-SY5Y c...

Background: In Alzheimer's disease, stroke and brain injuries, activated microglia can release proinflammatory cytokines, such as interleukin (IL)-1β. These cytokines may change astrocyte and neurotrophin functions, which influences neuronal survival and induces apoptosis. However, the interaction ...

Background In the last two decades, many studies have found that neuroinflammation is causally related to the onset [...]
Background In Alzheimer?s disease, stroke and brain injuries, activated microglia can release proinflammatory cytokines, such as interleukin (IL)-1[beta]. These cytokines may cha...

Eicosapentaenoic acid (EPA), a neuroactive omega-3 fatty acid, has been demonstrated to exert neuroprotective effects in experimental models of Parkinson's disease (PD), but the cellular mechanisms of protection are unknown. Here, we studied the effects of EPA in fully differentiated human SH-SY5Y c...

Preliminary evidence shows that ethyl-eicosapentaenoate (E-EPA) has a marked clinical effect when used as an adjunct in therapy-refractory depression. EPA belongs to the class of polyunsaturated omega-3 fatty acids. The mechanism of its action in depression is not fully understood. There are two rel...

Proinflammatory cytokine interleukin (IL)-1beta can cause cognitive impairment, activate the hypothalamic-pituitary-adrenal axis and impair monoaminergic neurotransmission in the rat. IL-1beta has also been shown to increase the concentration of the inflammatory mediator prostaglandin E2 (PGE2) in t...

Our previous study has pointed that arginine vasopressin (AVP) and norepinephrine (NA) are two most important bioactive substances that play a role in hypothalamic paraventricular nucleus (PVN) regulating pain process. The communication was designed to investigate the interaction between AVP and NA ...

Determined leucocyte adhesiveness/aggregation (LAA) during stress in 44 rats following sham operation or olfactory bulbectomy. The effects of chronic treatment with the antidepressant desipramine and calf thymopeptides on the LAA state and differential white cell count were also assessed. In the olf...

BACKGROUND: An increase in inflammatory response and an imbalance between T-helper (Th) 1 and 2 functions have been implicated in major depression. The aims of the present study were to 1) study the relationship between pro- and anti-inflammatory cytokines and between Th1 and Th2 produced cytokines ...

Background The n-3 polyunsaturated fatty acid, eicosapentaenoic acid (EPA) has been found to process neuroprotective effects. However, the exact cellular mechanisms are not well understood. Brain-derived neurotrophic factor (BDNF) is one of neurotrophins, which is involved in neuron differentiation,...

Examined the effects of chronic treatment with non-sedative histamine H-sub-1 receptor antagonist terfenadine on the behavioral and immunological parameters in the olfactory bulbectomized (OB) rat model of depression. OB Sprague-Dawley rats were injected with saline or terfenadine for 16 days after ...

Examined the effect of 2 neurogenic stressors (air puff and restraint) and a metabolic stressor (lipopolysaccharide; 100 ?g/kg) on accumbal serotonergic neurotransmission in the olfactory bulbectomized (OB) rat model of depression. Male Sprague-Dawley rats were used in 2 studies. Both puff and restr...

Investigated the effects of chronic treatment with serotonin (5-hydroxytryptamine [5-HT]) reuptake inhibitors, fluvoxamine (FL) and sertraline (SE) for 20 days on the behavior, neurotransmitter concentrations, and immune functions in the olfactory bulbectomized rat model of depression. Ss were adult...

Assessed the effect of chronic (3 mmol/kg for 15 days) lithium chloride (Li) on open field activity and immune function in bilaterally olfactory bulbectomized and sham-operated male rats. Li did not reverse the hyperactivity of the bulbectomized rats (BRs) and did not affect growth rate significantl...