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occurs when a normal protein that has a certain number of glutamines in a chain is mutated, so that the number of glutamines in the chain increases, it is an expanded chain. For example in Huntington’s Disease, a normal polyglutamine chain in the huntingtin protein would have from 10 to 35 glutamines, but an expanded polyglutamine chain would have more than 40 glutamines in a row.