High Cellularity Subvolume in Glioblastoma identified by High b-value Diffusion Weighted Images

1
Department of Radiation Oncology, University
of Michigan, Ann Arbor, MI, United States,
2
Department
of Radiology, University of Michigan, Ann Arbor, MI,
United States,
3
Department
of Neurology, University of Michigan, Ann Arbor, MI,
United States

The blood-brain(tumor)-barrier could impact therapeutic
efficacy of glioblastoma, particularly in the
non-enhanced component, which is difficult to
differentiate from edema using conventional MRI. This
study explores high b-value Diffusion Weighted Imaging (DWI)
as a means to identifying the non-enhanced solid tumor.
Our study shows that a large non-enhanced high cellular
tumor volume extracted from b=3000 s/mm^2 DWI is
associated with a higher likelihood of non-central
recurrence. High b-value DWI shows promise for aiding in
radiation therapy target volume definition.

This abstract and the presentation materials are available to members only;
a login is required.