Initial characterization of human ALDH3B1 suggests a potential physiological role of this protein in oxidative stress processes.

These findings provided convincing evidence that epistasis between the catechol-O-methyltransferase (show COMT ELISA Kits) and aldehyde dehydrogenase 3B1 genes plays an important role in the pathogenesis of schizophrenia

ALDH3B1 Antigen Profile

Antigen Summary

This protein belongs to the aldehyde dehydrogenase family of proteins. This enzyme is a mitochondrial matrix NAD-dependent dehydrogenase which catalyzes the second step of the proline degradation pathway, converting pyrroline-5-carboxylate to glutamate. Deficiency of this enzyme is associated with type II hyperprolinemia, an autosomal recessive disorder characterized by accumulation of delta-1-pyrroline-5-carboxylate (P5C) and proline. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.