This research was supported in part by the European Community's Marie Curie Research Training Network under contract MRTN-CT-2003-505086 (CLUSTOXDNA). The support and sponsorship concerned by COST Action CM0603 on “Free Radicals in Chemical Biology (CHEMBIORADICAL)” are kindly acknowledged. We thank M. Lavalle, A. Monti, and A. Martelli for assistance with the pulse radiolysis experiments.

Abstract

Radically different: Contrary to previous proposals, the main reaction of the HO. radical with guanosine or 2′-deoxyguanosine is the hydrogen abstraction from the NH2 moiety to give a guanyl radical. This radical, characterized by a broad band in the visible region (around 610 nm), undergoes tautomerization to the most stable isomer.

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Funded by

European Community's. Grant Number: MRTN-CT-2003-505086

COST Action

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