1.
Kirstie Alley and cast in the new sitcom "Kirstie," that centers on Alley as a Broadway star and a new parent. It reunited her with former Cheers co-star Rhea Perlman and Seinfeld star Michael Richards. The series premiered on December 4, 2013.
TV Land

2.
Actress Kirstie Alley attends the "Kirstie" premiere party at Harlow on December 3, 2013 in New York.
Robin Marchant / Getty Images

3.
Kirstie Alley attends a signing for her book 'The Art of Men' at Barnes & Noble bookstore at The Grove on November 11, 2012 in Los Angeles.
Araya Diaz / FilmMagic

4.
Kirstie Alley was paired with Maksim Chmerkovskiy in season 12 of "Dancing With the Stars." The actress made it to the finals of the reality TV competition in 2011.
ABC

5.
Alley arrives at the premiere of "Pirates Of The Caribbean: On Stranger Tides" on Saturday, May 7, 2011 in Anaheim, Calif.
Jordan Strauss / Getty Images Contributor

6.
Actress Kirstie Alley has always been very public about her beliefs and her life, including her struggles with her weight. Here are highlights of her colorful career.

Starting in March 2010, the A&E reality series Kirstie Alley's Big Life follows the actress as she battles with her weight, launches her own weight-loss company, raises her two children, and looks for love.
A&E

7.
Kirstie Alley appeared on Oprah in February 2010 to talk about her battle for weight loss. She also talked about her new show, Kirstie Alley's Big Life, and admitted to a crush on Jamie Foxx.
WENN

8.
In January 2010, Kirstie Alley launched Organic Liaison, a USDA-certified organic weight-loss product. A public advocate against obesity, Alley has also appeared in ads for the Jenny Craig weight-loss program.
organicliaison.com

9.
Kirstie Alley was all smiles as she left Katsuya restaurant in Hollywood on Jan. 14, 2010 with her adopted daughter, Lillie Price, and adopted son, William True.
PacificCoastNews

10.
The headline said it all on the cover of the May 18, 2009 issue of People magazine. "I fell off the horse," the actress admitted in the cover story.
People

11.
On Nov. 6, 2006, Kirstie Alley appeared in a bikini on Oprah. She told the daytime host that she had lost 75 pounds.
WENN

12.
In January 2005, Kirstie Alley appeared during the Television Critics Winter Press Tour in Universal City, Calif., to promote Fat Actress, a mockumentary-style comedy series on Showtime in which she starred.
Frederick M. Brown / Getty Images

13.
In May 2003, Kirstie Alley led protesters in a march against the American Psychiatric Association in San Francisco. Alley is a member of Scientology, which is hostile to psychiatry.
Justin Sullivan / Getty Images

16.
In Toothless, a 1997 fantasy TV-movie, Kirstie Alley played a dentist who died but then was sent back to Earth as a tooth fairy.
Walt Disney via Everett Collection

17.
Kirstie Alley posed for this publicity still for the 1997-2000 TV sitcom Veronica's Closet. Over the show's run she earned Emmy, Golden Globe and SAG Award nominations in the title role.
Getty Images

18.
In the 1996 TV-movie Suddenly, Kirstie Alley tackled a dramatic role as s a waitress crippled in a traffic accident. Jason Beghe costarred.
Everett Collection

19.
After two previous nominations, Kirstie Alley won an Emmy in 1991 for her work on Cheers. In her acceptance speech, she famously thanked then-husband Parker Stevenson "for giving me the big one for the last eight years."
Jim Smeal / WireImage

20.
Kirstie Alley was married to actor Parker Stevenson from 1983 to 1997. During their marriage, the couple adopted two children.
Diane Freed / Getty Images

21.
Kirstie Alley appeared with a young Patrick Dempsey in the 1989 comedy film Loverboy.
Everett Collection

22.
Kirstie Alley costarred with (from left) John Travolta, Olympia Dukakis and George Segal in the 1989 comedy "Look Who's Talking." The film was a hit and spawned several sequels.
TriStar Pictures

24.
Kirstie Alley played a member of a prominent Pennsylvania family in North and South, an acclaimed 1985 TV miniseries set in the Civil War era. The cast also included (from left) Robert Guillaume and David Ogden Stiers.
Warner Bros via Everett Collection

25.
Kirstie Alley played feminist Gloria Steinem (right) in the 1985 TV-movie A Bunny's Tale, which was based on Steinem's experiences working as a Playboy Bunny.
David Bookstaver / AP

26.
In 1983, Kirstie Alley played Maggie "The Cat" in a stage production of Tennessee Williams' Cat on a Hot Tin Roof in Los Angeles.
Ron Galella / WireImage

27.
Kirstie Alley played the half-Vulcan officer Saavik in the 1982 movie Star Trek II: The Wrath of Khan. Reportedly she was chosen for the role because she resembled Trek creator Gene Roddenberry's image of what a Vulcan should look like.
Paramount Pictures