BACKGROUND

Therapeutic needs of migraineurs vary considerably from patient to patient and even attack to attack. Some attacks require high-end therapy, while other attacks have treatment needs that are less immediate. While triptans are considered the “gold standard” of migraine therapy, they do have limitations and many patients are seeking other therapeutic alternatives. In 2005, an open-label study of feverfew/ginger suggested efficacy for attacks of migraine treated early during the mild headache phase of the attack.*

PRIMARY OBJECTIVE

To assess the efficacy of sublingually administered preparation of feverfew/ginger in providing relief of headache and associated symptoms in acute migraine when administered early in the process of migraine.

SECONDARY OBJECTIVES

METHOD OF STUDY

The double-blind, placebo-controlled, randomized s tudy was approved by an independent investigational review board and was conducted at three headache specialty centers in the United States.

Sixty subjects,** ages 12 – 60, who met International Headache Society (IHS) diagnostic criteria (1988) for migraine without aura (IHS 1.1) or migraine with aura (IHS 1.2) were enrolled in the study. The subjects had a history of migraine for greater than 1 year with an attack frequency between 2 – 6 attacks per month over the previous 3 months. Seventy-five percent of the reported attacks began with mild headache that could be differentiated between migraine and non-migraine.

Eligible subjects were encouraged, but not required, to treat migraine at the onset of attack during the mild pain phase with LipiGesic M. One treatment consisted of two 3ml LipiGesic M doses administered sublingually 5 minutes apart. A second treatment could be taken if needed for persistent or recurrent pain between 1 and 24 hours. Subjects recorded response to treatment in diaries.

RESULTS

At 2 hours post-dose, the percentage of attacks that was rated as no pain or mild pain was 64% for sublingual feverfew/ginger compared to 39% for placebo.

At 2 hours post-dose, there was a statistically significant difference in associated migraine symptoms and headache characteristics between active and placebo groups.

This included statistical superiority for feverfew/ginger over placebo in eliminating the pulsating character of the headache (P = .007), the worsening of headache with activity (0.015), and the presence of light sensitivity (0.001), sound sensitivity (0.003), and nausea (P=.002).

Sublingual feverfew/ginger was well tolerated in this study. Adverse events were mild, similar to the placebo group with the exception of oral numbness.

CONCLUSIONS

Sublingual feverfew/ginger appears safe and effective as a first-line abortive treatment for a population of migraineurs who frequently experience mild headache prior to the onset of moderate to severe headache. It appears to be well tolerated and has no known contraindications with other acute treatments for migraine.

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Testimonials

A friend of mine shared LipiGesic with me a year ago. I was skeptical at first, after suffering from migraines my whole life, nothing had really worked. The first time I took it, I did not even experience the headache. It is the first time I have had migraine relief from any kind of ‘medication.’ After finding LipiGesic, I now no longer need to take pain or migraine medication! I always carry two, one for myself and one for a stranger in need.

~Rose K., Arizona

Jacklyn (age 15) started having intense pain between her eyes and light sensitivity. I ran and got the LipiGesic-M. It was AMAZING! The migraine was stopped DEAD in its tracks.

Marybeth of Doylestown, PA

Hi,my name is Kim and I have been getting migraines since I was 10 years old.

Nobody knew back then that it was a migraine. My parents thought that I just didn’t want to go to school cause they never had a migraine or headaches. They say it is hereditary but no one in my family had them.

As the years went by, they had started to get worse. Especially around my period. They would last 3 days. Sometimes they would last a week or even a month.

A few years back,my doctor put me on migraine medication, imitrex, relpax, midrin, sumavel dose pro, keppra and topamax to prevent them. Topamax had bad side effects that would also make me sick all over like the flu.

I am 54 now and recently I started taking Lipigesic M and was so amazed how well it works to my happy surprise:) It is very inexpensive also:) As most of all prescription migraine medication is very spendy.

This Lipigesic M is a miracle cure and is all natural with no side effects:) It is peppermint flavored also,which tastes great:) I highly recommend it to everyone.

Kim M

My father found LipiGesic in a newspaper ad last year. After not having any luck with even prescription medications, I decided to try it.

Within seconds after putting it in my mouth, the migraines dissipate. Within a few minutes, the migraines disappear completely. “Stopping dead in it’s tracks” is an understatement.

I finally have gotten some relief. As great as this works, I would pay triple for. Thank you for such an incredible product.

~Garrett D

Ever since a car accident in 2006, I have been getting migraine headaches. LipiGesic-M works like a charm to stop the migraine within 5 minutes. My wife and kids use it all the time.

S. Cronin of Rothchild, WI

I met Jim on a plane and told him about a headache I’ve had everyday for months. He gave me some samples of the LipiGesic-M migraine product… within 10 minutes my headache was gone.

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If you purchased LipiGesic M on our website and are not satisfied after trying your free box for 30-days, call Customer Service at 877-852-5295 for your return authorization number (REN). You will need to return two (2) unopened boxes of LipiGesic M to the address that the customer service representative will provide. No return products […]