Just before the shift to the otherworld in the hospital, the nurse Lisa who appears in the first game can be seen. The purpose of including this is to show that Alessa’s influence on the otherworld grows stronger as she regains her memories. It indicates that even after the first game she continues to suffer in the otherworld. Although a nurse appears in a similar fashion in the church as well, this does not have anything to do with Lisa.
Masahiro Ito , Silent Hill 3, The Book of Lost Memories