nonetheless, a 80% five yr survival may be associated with this anomaly

Cytogenetics

additional anomalies are most often found

Hybrid/Mutated Gene

5' NPM1-3' ALK on der(5)

Abnormal Protein

680 amino acids, 80 kDa; N-term 116 amino acids from NPM1 fused to the 563 C-term aminoacids of ALK (i.e. composed of the oligomerization domain and the metal binding site of NPM1 ,and the entire cytoplasmic portion of ALK); no apparent expression of the ALK/NPM1 counterpart; Characteristic localisation both in the cytoplasm and in the nucleus, due to heterooligomerization of NPM-ALK and normal NPM whereas the normal NPM protein is confined to the nucleus; constitutive activation of the catalytic domain of ALK.

Oncogenesis

via the kinase function activated by oligomerization of NPM1-ALK mediated by the NPM1 part