the electrostatic regulatory interaction between the SPRY2 F loop residues (that bind to imperatoxin A) and the ASI/basic residues of RyR1 does not influence bi-directional DHPR-RyR1 signaling during skeletal EC coupling

Data show that intrauterine growth restriction increases serotonin biosynthesis in the brainstem, which is accompanied by an increase in dihydropteridine reductase activity that may be a compensatory mechanism to maintain sufficient tetrahydrobiopterin.