Studies of the genetic basis of complex disease present statistical and methodological challenges in the discovery of reliable and high-confidence genes that reveal biological phenomena underlying the etiology of disease ...

In low-resource settings, the prioritization of clinical care funding is often determined by immediate health priorities. As a result, investment directed towards the development of standards for clinical data representation ...

Use of a complete problem list can benefit patient care, quality improvement initiatives, and research activities. However, it can be time consuming for physicians to enter the correct encoded problem from a standardized ...

Cervical cancer is the second most frequent cancer in women around the world and affects half a million women per year. The World Health Organization (WHO) estimates that 275,000 women die every year, and 80% to 85% of ...

Access to primary data and the provenance of derived data are increasingly recognized as an essential aspect of reproducibility in biomedical research. While productive data sharing has become the norm in some biomedical ...

The increasing adoption of electronic medical records is producing a massive accumulation of routinelly collected electronic clinical data (ECD). This data can be used not only for direct patient care but for secondary ...

Clinical trial protocols are important documents that guide clinical research. Modern protocol development requires collective expertise from a group of Loosely-Coupled protocol writers, who work across distances and time ...

Synthetic biology is the emerging research and engineering field concerned with the design and construction of new biological functions and systems. Synthetic biologists are engineering organisms to solve outstanding ...

Every 25 seconds someone in the US has a cardiac event and one person per minute will die from it. ST-elevated myocardial infarction (STEMI), non ST-elevated myocardial infarction and unstable angina are caused by ischemia ...

Ontologies have become increasingly important for both representation of biomedical knowledge and for using that knowledge to facilitate data integration. However, ontologies are generally not presented in ways that are ...

The structural dynamics of proteins are integral to protein function; if these structural dynamics are altered by mutation, the function of the protein can be altered as well, potentially resulting in disease. Experimental ...

The real-time documentation of medications and procedures is an essential part of managing patient care during in-hospital "code blue" cardiac arrest emergencies. Care providers have voiced dissatisfaction with the existing ...