Bivariate and multivariable analysis of 30-day mortality after start of systemic treatment in patients with lung cancer

Subjects

30-day mortality#

p-value

OR (95% CI)

Age years

18–59

7420 (28)

4.6

<0.001

1

60–69

10 555 (40)

6.0

1.3 (1.2–1.5)

70–79

7163 (27)

7.5

1.7 (1.5–2.0)

≥80

1139 (4)

9.8

2.3 (1.8–2.9)

Year of diagnosis

2010

4253 (16)

6.4

0.15

2011

4254 (16)

7.0

2012

4389 (17)

6.2

2013

4364 (17)

6.1

2014

4475 (17)

5.6

2015

4542 (17)

6.0

Sex

Male

14 719 (56)

6.5

0.03

Female

11 558 (44)

5.8

Stage

IIIA

4515 (17)

2.5

<0.001

¶

IIIB

4330 (16)

3.6

IV

17 432 (66)

7.8

Histology

Adenocarcinoma

10 883 (41)

5.3

<0.001

1

Squamous

4414 (17)

4.4

1.1 (0.9–1.3)

Other NSCLC

3770 (14)

6.5

1.4 (1.2–1.6)

SCLC

7210 (27)

8.5

1.7 (1.5–1.9)

Metastatic sites involved n

0

8841 (34)

3.0

<0.001

1

1

9182 (35)

6.0

2.1 (1.8–2.4)

2

4865 (19)

8.6

3.0 (2.6–3.5)

≥3

3389 (13)

11.5

4.3 (3.7–5.1)

Type of treatment

Chemotherapy

25 010 (95)

6.1

<0.001

1

Targeted

1267 (5)

8.6

1.3 (1.1–1.6)

Data are presented as n (%) or %, unless otherwise stated. NSCLC: non-small cell lung cancer; SCLC: small cell lung cancer. #: as percentage of the population within this group; ¶: not included in multivariable analysis to avoid collinearity.