How is Risedronate superior to Alendronate?

Answered by: Dr Chandra M Gulhati | Editor, MIMS, New Delhi

Q:It is known that Alendronate is second generation bisphosphate and Risedronate is third generation. Its also said that Risedronate is superior to Alendronate in terms of its mode of action and it acts faster. How is Risedronate sodium superior to Alendronate sodium in terms of its mode of action?

A:Alendronate, etidronate, pamidronate, risedronate etc. all belong to the same class of drugs and very similar efficacy and safety. There is no significant difference. They are indicated for use in women with post-menopausal osteoporosis.