GenDR Dietary Restriction Gene Manipulation: Ghr

Gene Information (Entrez Gene ID: 14600)

Potential relevance to dietary restriction and ageing

Observations

Ghr knockout mice (GHRKO) are dwarfs with significantly extended lifespan by up to 40% [3]. DR (30%) fails to affect overall survival, average or median long-lifespan of GHRKO mice and increased maximal lifespan only in females. Insulin sensitivity in GHRKO mutants is greater than in wild-type and is not further increased by DR [1773]. Intermittent fasting also fails to extend the long lifespan of GHRKO mice [2583]. GHR-knockout mice live longer than wild-type mice when their diet contains 0.43% or 1.3% methionine. Contrastly, there is a minimal difference in lifespan on a diet of 0.16% methionine, wild-type mice being under these conditions long-lived as well [3476].