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Umicore has taken out a license to use palladium precatalysts developed by Yale University chemistry professor Nilay Hazari for cross-coupling reactions. The precatalysts can be rapidly activated, Umicore says, enabling shorter reaction times and lower catalyst loadings. They also can be used with a variety of ancillary ligands, resulting in broad substrate compatibility. They are suitable for commercial-scale fine chemical manufacturing, Umicore says.