Histadur
msds (material safety sheet)

Histadur
Synthesis Reference

Histadur
Molecular Weight

Histadur
Melting Point

Histadur
H2O Solubility

Histadur
State

Histadur
LogP

3.563

Histadur
Dosage Forms

Liquid; Syrup; Tablet; Tablet (extended-release)

Histadur
Indication

For the treatment of rhinitis, urticaria, allergy, common cold, asthma and hay fever.

Histadur
Pharmacology

In allergic reactions an allergen interacts with and cross-links surface IgE antibodies on mast cells and basophils. Once the mast cell-antibody-antigen complex is formed, a complex series of events occurs that eventually leads to cell-degranulation and the release of histamine (and other chemical mediators) from the mast cell or basophil. Once released, histamine can react with local or widespread tissues through histamine receptors. Histamine, acting on H1-receptors, produces pruritis, vasodilatation, hypotension, flushing, headache, tachycardia, and bronchoconstriction. Histamine also increases vascular permeability and potentiates pain. Chlorpheniramine, is a histamine H1 antagonist (or more correctly, an inverse histamine agonist) of the alkylamine class. It competes with histamine for the normal H1-receptor sites on effector cells of the gastrointestinal tract, blood vessels and respiratory tract. It provides effective, temporary relief of sneezing, watery and itchy eyes, and runny nose due to hay fever and other upper respiratory allergies.

Histadur
Absorption

Well absorbed in the gastrointestinal tract.

Histadur
side effects and Toxicity

Histadur
Patient Information

May cause excitability especially in children. Do not take this
product unless directed by a physician, if you have a breathing problem such as emphysema or chronic bronchitis, or
if you have glaucoma or difficulty in urination due to enlargement of the prostate gland. May cause drowsiness;
alcohol, sedatives and tranquilizers may increase the drowsiness effect. Avoid alcoholic beverages, and do not take
this product if you are taking sedatives or tranquilizers without first consulting your physician. Use caution when
driving a motor vehicle or operating machinery.