Got menobrain?

Boy, oh boy, I sure do. Forgetful, unfocused, downright ditzy. Will an extra boost of estrogen help? Not according to newly published data in the Proceedings of the National Academy of Sciences. In fact, researchers are now starting to dispute the link between declining levels of estrogen and cognition. And this, my dear friends, blows the lid off the roof when it comes to HRT and its use in boosting our thinking.

In this study, researchers tested 643 women — roughly half of whom started menopause within six years and the others, who were more than ten years into menopause. They also measured hormone levels, i.e. estradiol (naturally circulating estrogen), progesterone, testosterone and a hormone that binds specifically to so-called sex hormones. And, when they conducted analyses for each hormone separately, they found no link between declines in levels of estradiol and cognition in either group. Nevertheless, levels of progesterone were associated with better verbal memory and overall cognition in the women who were six years into the ‘pause.

So, what’s it all about? First of all, years into menopause (which equates to years of estrogen decline) do not appear to make a difference in mental focus. Moreover, it appears that if you are heading toward the HRT train to improve your memory and sharpen your thinking, you may want to hop off the next stop before you run the risk of developing serious diseases; the bottom line is that HRT is not the panacea for sharpening thinking and lessening the hazy menobrain. Additionally, a topical progesterone cream might be just the ticket to a thinking cap that doesn’t slip off over time.

Mind you, this doesn’t mean that estrogen has no effect on the brain whatsoever; that information should be filed under ‘TBD.’ But, if you are thinking HRT and preservation of your precious thinking cap, you may want to think again.