Rat studies suggest
heritable epigenetic modifications induced by liver fibrosis could help
predict long-term liver damage susceptibility in offspring. In male offspring
of rats with a history of chemically induced liver damage, fewer liver
myofibroblasts were generated, liver levels of antifibrotic peroxisome proliferation-activated
receptor-g
(PPARG;
PPARg) were
increased and levels of profibrotic transforming
growth factor-b (TGFB; TGFb) were
decreased compared with what was seen in rats from parents that underwent
sham injury. In sperm from rats with liver fibrosis, epigenetic modifications
occurred that were absent in sperm from rats without fibrosis. Ongoing
studies include testing whether epigenetic mutations occur in human patients
and predicting risk of long-term liver damage.

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