Robert A KlonerDepartment of Medicine, Division of Cardiovascular Medicine of Keck School of Medicine and Good Samaritan Hospital, University of Southern California, Los Angeles, CA, USAAm J Cardiol 111:1671-6. 2013

Robert A KlonerDivision of Cardiovascular Medicine, Keck School of Medicine of the University of Southern California, Heart Institute, Good Samaritan Hospital, Los Angeles, California 90017, USAClin Cardiol 27:I20-5. 2004

..Mitochondria-produced reactive oxygen species are believed to be centrally involved in each of these aspects of reperfusion injury, although currently no therapies reduce reperfusion injury by targeting mitochondria specifically...

Erectile dysfunction and heart failure: the role of phosphodiesterase type 5 inhibitors

..Overall, ranolazine (in doses of 500 mg and 1000 mg, twice daily) is a safe and effective option for monotherapy or add-on therapy to reduce anginal symptoms in patients with CSA. ..

Sexual function in patients with chronic angina pectoris

Robert A KlonerDepartment of Medicine, Division of Cardiovascular Medicine of Keck School of Medicine and Good Samaritan Hospital, University of Southern California, Los Angeles, CA, USAAm J Cardiol 111:1671-6. 2013

..PDE5Is might also benefit patients with treatment-resistant hypertension, preeclampsia, or peripheral arterial disease. This review presents the pathophysiology and trial data with regard to the use of PDE5Is for cardiac diseases...

Uncertainty on the use of aldosterone antagonists for primary therapy for sudden cardiac death in the setting of implanted devices

Robert A KlonerDivision of Cardiovascular Medicine, Keck School of Medicine of the University of Southern California, Heart Institute, Good Samaritan Hospital, Los Angeles, California 90017, USAClin Cardiol 27:I20-5. 2004

..Sildenafil has an alpha-blocker precaution; tadalafil is contraindicated with alpha blockers except for 0.4 mg tamsulosin; vardenafil is contraindicated with alpha blockers...

Cardiovascular effects of the 3 phosphodiesterase-5 inhibitors approved for the treatment of erectile dysfunction

Robert A KlonerHeart Institute, Good Samaritan Hospital, and the Division of Cardiovascular Medicine, Keck School of Medicine, University of Southern California, Los Angeles 90017, USACirculation 110:3149-55. 2004

Interaction between the phosphodiesterase 5 inhibitor, tadalafil and 2 alpha-blockers, doxazosin and tamsulosin in healthy normotensive men

..We examined the hemodynamic interactions of tadalafil with the alpha-blockers doxazosin and tamsulosin...

A case of erectile dysfunction and risk factors for coronary artery disease

R A KlonerHeart Institute, Good Samaritan Hospital and Division of Cardiovascular Medicine, Keck School of Medicine at the University of Southern California, Los Angeles, 90017, USAInt J Impot Res 17:S7-S11. 2005

..Methods to optimize efficacy of the phosphodiesterase inhibitors are described. The overall cardiovascular safety of the phosphodiesterase inhibitors and their interaction with organic nitrates and alpha blockers are discussed...

..In contrast, recent studies have shown that PDE5 inhibitors may have therapeutic potential for a host of cardiovascular diseases. In general, these agents, when used appropriately, are highly safe and effective...

..Some have estimated that nearly one half of all causes of ED in men over 50 years of age are vascular in nature. This article reviews cardiovascular risk factors of ED...

Preconditioning, postconditioning and their application to clinical cardiology

Robert A KlonerHeart Institute, Good Samaritan Hospital, Division of Cardiovascular Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90017, United StatesCardiovasc Res 70:297-307. 2006

..In this clinical trial population of men with erectile dysfunction, tadalafil was not associated with an increased risk for serious cardiovascular adverse events...

Impact of time to therapy and reperfusion modality on the efficacy of adenosine in acute myocardial infarction: the AMISTAD-2 trial

Robert A KlonerHeart Institute, Good Samaritan Hospital, Cardiovascular Division of the Keck School of Medicine at University of Southern California, Los Angeles, CA 90017, USAEur Heart J 27:2400-5. 2006

..The purpose of this analysis was to determine whether the efficacy of adenosine vs. placebo was dependent on the timing of reperfusion therapy in the second Acute Myocardial Infarction Study of Adenosine (AMISTAD-II)...

..Endothelial dysfunction and atherosclerosis of blood vessels that supply the penis are associated with the same cardiovascular risk factors that affect the coronary arteries: smoking, lipid abnormalities, hypertension, and diabetes...

Population-based analysis of the effect of the Northridge Earthquake on cardiac death in Los Angeles County, California

..More importantly, the responses to tadalafil were similar regardless of concomitant thiazide use. Additionally, responses to tadalafil were comparable between thiazide and nonthiazide users regardless of baseline ED severity (P>0.05)...

Comparison of acute myocardial infarct size in patients > or =65 years versus < 65 years in the prethrombolytic period versus the thrombolytic period

..Total and cardiac mortality rates in Los Angeles County, California, increased after the 1980 Super Bowl loss (SBL), but there was an overall reduction in total mortality after the 1984 Super Bowl win (SBW)...

First direct comparison of the late sodium current blocker ranolazine to established antiarrhythmic agents in an ischemia/reperfusion model

..If cardiovascular risk factors are identified, they should be worked up and aggressively treated--as treatment of these risk factors may be life-saving...

Blood pressure control with amlodipine add-on therapy in patients with hypertension and diabetes: results of the Amlodipine Diabetic Hypertension Efficacy Response Evaluation Trial

Robert A KlonerHeart Institute, Good Samaritan Hospital Professor of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90017, USAAnn Pharmacother 42:1552-62. 2008

..While therapeutic guidelines advise initial therapy with an angiotensin-converting enzyme inhibitor or angiotensin receptor blocker, monotherapy with these agents may not be sufficient to attain target BP...

Comparison of total and cardiovascular death rates in the same city during a losing versus winning super bowl championship

..3205 for control days, p = 0.0302). In conclusion, the emotional stress of loss and/or the intensity of a game played by a sports team in a highly publicized rivalry such as the Super Bowl can trigger total and cardiovascular deaths...

..However, most cardiologists do not routinely ask about ED and patients often are reluctant or embarrassed to discuss it. We determined how common ED was in a group of patients with chronic stable coronary artery disease...

..PoC did not reduce infarct size in this model, nor did it reduce the extent of the anatomic zone of no reflow, suggesting that this intervention may not impact postreperfusion microvascular damage due to ischemia...

..Thus microvascular reperfusion injury led to a striking decrease in RMBF within the first 2 h of reperfusion, with infarct size as the major determinant of reflow at a given time point of reperfusion...

..Ranolazine treatment reduced myocardial stunning following brief ischemia/reperfusion suggesting that inhibiting the late sodium channel current may be a novel approach to treating stunning independent of effects on hemodynamics...

A 4-year update on the safety of sildenafil citrate (Viagra)

Harin Padma-NathanThe Male Clinic, Keck School of Medicine at the University of Southern California School of Medicine, Beverly Hills, California, USAUrology 60:67-90. 2002

..Lastly, we review the specific effects on the visual system based on findings from studies conducted during drug development and post marketing...

The antianginal agent, ranolazine, reduces myocardial infarct size but does not alter anatomic no-reflow or regional myocardial blood flow in ischemia/reperfusion in the rabbit

..7% in SHR versus WKY ( P < .05). The results of this study suggest that although UFP depress myocardial contractile response and coronary flow in both SHR and WKY the underlying hypertension does not necessarily worsen the response...

Is microvascular protection by cariporide and ischemic preconditioning causally linked to myocardial salvage?

..Because size and spatial distribution of no reflow and myocardial necrosis remained closely coupled with independent cardioprotective interventions, a potential causal connection between microvascular and myocardial salvage is discussed...

Microvascular reperfusion injury: rapid expansion of anatomic no reflow during reperfusion in the rabbit

..No-reflow after reperfusion therapy for myocardial infarction is a strong predictor of clinical outcome. But its fate on a long-term basis and potential significance for infarct healing are not yet known...

..However, MSC may not remain in the heart, but instead relocate to other areas. We investigated quantitatively the distribution of labeled rat MSC, given by two routes after coronary artery occlusion/reperfusion in rats...

..The purpose of this research was to determine the effect of intravenous adenosine on clinical outcomes and infarct size in ST-segment elevation myocardial infarction (STEMI) patients undergoing reperfusion therapy...

The "Merry Christmas Coronary" and "Happy New Year Heart Attack" phenomenon

Robert A KlonerCirculation 110:3744-5. 2004

The second Princeton consensus on sexual dysfunction and cardiac risk: new guidelines for sexual medicine

..brief PC ischemia was not associated with activation/translocation of PKC-epsilon. Thus the mechanisms responsible for PC are age related in the rabbit heart, with no apparent, requisite role of PKC-epsilon in aging animals...

Research Grants3

..Identification and characterization of transplants will be carried out with PCR analysis of the Y chromosome (male cells into female host), detailed histologic analysis and immunostaining for muscle cell markers. ..