Sisomicin sulfate

Sisomicin sulfate is a soluble broad-spectrum aminoglycoside antibiotic, and a dihydro analog of gentamicin C1a sulfate, Evopure. Sisomicin was first isolated in 1970 from Micromonopora inyoensis, a novel strain at the time, that was obtained from soil samples collected in the Inyo National Forest in California.

Sisomicin sulfate is a bacterial protein synthesis inhibitor that binds to the 30s ribosomal subunit, causing misreading of the mRNA sequence and inhibiting translocation. It is effective against most strains of Klebsiellk spp., Escherichia coli, P. aeruginosa, Enterobacter and Proteus spp.. It is a potential treatment for conjunctiva. Sisomicin has been used in disk and tube dilution sensitivity tests.

Sisomicin is generally more potent than gentamicin, and has show effective antibacterial synergy with beta-lactam antibiotics against a large range of bacteria.