Editorial Comment; Non-ischemic cardiomyopathy (NICM) is characterized by myocardial dysfunction in the absence of significant coronary artery disease. Myocardial cellular replacement by scar tissue leads to further mechanical dysfunction as well as ventricular tachycardia (VT) in some of these patients. The heterogeneous and often complex substrate distribution in such cases creates unique challenges for catheter based ablation therapy. This article is protected by copyright. All rights reserved.