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This is the 17th year Fortune has ranked the Most Powerful Women in business outside the U.S. Banco Santander group executive chairman Ana Botín repeats again as No. 1 in 2017, though she is joined on this year’s list by 11 newcomers. The 50 global businesswomen here represent 17 countries and many industries. By Christina Austin, Laura Entis, Erika Fry, Polina Marinova, and Claire Zillman. Click here for our methodology.

Nancy McKinstry

Chairman and CEO, Wolters Kluwer, 58

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Courtesy of Wolters Kluwer

McKinstry has a habit of making history. She’s the first female, and the first American CEO of Wolters Kluwer, the $5.1 billion global information services company she has helmed for 14 years. She’s long been the only woman to run a large publicly listed company in the Netherlands, and she’s also currently the longest-sitting CEO in the country. Wolters Kluwer, which operates in 40 countries and employs 19,000, counts as customers 90% of U.S. academic medical centers, 80% of Fortune 500 companies, and all 100 of the U.S.’s top accounting firms. The company had a solid 2016: In local currency, sales edged up 2%, and profits jumped 15%. McKinstry—who serves on the boards of Abbott, Russell Reynolds Associates, and Columbia Business School—also joined as a director at Accenture last year.