Bottom Line:
Inhaled gene therapy has presented safety and effectiveness previously in cystic fibrosis.During the last decade, numerous new nanocomplexes have been created and investigated as a safe gene delivery nano-vehicle.These formulations are multifunctional; they can be used as either local therapy or carrier for an effective inhaled gene therapy for lung cancer.

ABSTRACTNovel aerosol therapeutic modalities have been investigated for lung cancer. Inhaled gene therapy has presented safety and effectiveness previously in cystic fibrosis. However, safety concerns have been raised regarding the safety of non-viral vectors for inhaled gene therapy in lung cancer, and therefore small steps have been made towards this multifunctional treatment modality. During the last decade, numerous new nanocomplexes have been created and investigated as a safe gene delivery nano-vehicle. These formulations are multifunctional; they can be used as either local therapy or carrier for an effective inhaled gene therapy for lung cancer. Herein, we present current and future perspectives of nanocomplexes for inhaled gene therapy treatment in lung cancer.

Mentions:
In this section, all previous delivered nanocomplexes are presented with an emphasis on safety. Inhaled therapy safety concerns can be divided in two parts. The first consists of the drug formulation interaction with the medical personal administering the aerosol compound, and the second part, the drug formulation interaction with the patients or animal. Previous studies indicated that chemotherapeutic nanocomplexes induce bronchospasm, edema, hemoptysis and fibrotic lesions to the lungs [30,31] (Table 1, Figure 3).

Mentions:
In this section, all previous delivered nanocomplexes are presented with an emphasis on safety. Inhaled therapy safety concerns can be divided in two parts. The first consists of the drug formulation interaction with the medical personal administering the aerosol compound, and the second part, the drug formulation interaction with the patients or animal. Previous studies indicated that chemotherapeutic nanocomplexes induce bronchospasm, edema, hemoptysis and fibrotic lesions to the lungs [30,31] (Table 1, Figure 3).

Bottom Line:
Inhaled gene therapy has presented safety and effectiveness previously in cystic fibrosis.During the last decade, numerous new nanocomplexes have been created and investigated as a safe gene delivery nano-vehicle.These formulations are multifunctional; they can be used as either local therapy or carrier for an effective inhaled gene therapy for lung cancer.

ABSTRACTNovel aerosol therapeutic modalities have been investigated for lung cancer. Inhaled gene therapy has presented safety and effectiveness previously in cystic fibrosis. However, safety concerns have been raised regarding the safety of non-viral vectors for inhaled gene therapy in lung cancer, and therefore small steps have been made towards this multifunctional treatment modality. During the last decade, numerous new nanocomplexes have been created and investigated as a safe gene delivery nano-vehicle. These formulations are multifunctional; they can be used as either local therapy or carrier for an effective inhaled gene therapy for lung cancer. Herein, we present current and future perspectives of nanocomplexes for inhaled gene therapy treatment in lung cancer.