Clinical Trials for Omnipaque 350

Patients who are scheduled by their health care provider for routine computed tomography
(CT) scan will be asked to participate in this study. The primary purpose is to determine if
there is a difference in patient preference for Omnipaque versus Gastroview as oral contrast
for abdominal pelvic CT. A secondary objective is to evaluate if there is significant
difference in bowel opacification for the two agents.

Patients who are scheduled by their health care provider for routine computed tomography
(CT) scan will be asked to participate in this study. The primary purpose is to determine if
there is a difference in patient preference for Omnipaque versus Gastroview as oral contrast
for abdominal pelvic CT. A secondary objective is to evaluate if there is significant
difference in bowel opacification for the two agents.

The investigators goals are:
1. to develop software for quantitative volumetric analysis of myocardial perfusion from
MDCT images
2. to test its ability to accurately determine the presence, location, extend and severity
of perfusion abnormalities in agreement with conventional diagnostic techniques (ICA
and MPI) in patients with normal and abnormal coronary arteries and/or perfusion
patterns
3. to test this approach in patients undergoing vasodilator stress tests with MDCT imaging
in combination with the new vasodilator stress agent Regadenoson.

The investigators goals are:
1. to develop software for quantitative volumetric analysis of myocardial perfusion from
MDCT images
2. to test its ability to accurately determine the presence, location, extend and severity
of perfusion abnormalities in agreement with conventional diagnostic techniques (ICA
and MPI) in patients with normal and abnormal coronary arteries and/or perfusion
patterns
3. to test this approach in patients undergoing vasodilator stress tests with MDCT imaging
in combination with the new vasodilator stress agent Regadenoson.

Glomerular filtration rate (GFR) is widely accepted as the best index of kidney function in
health and disease, and accurate values are required for optimal clinical decision making
and in large-scale epidemiologic studies and clinical trials. Current recommended methods
for measuring GFR are expensive, cumbersome to administer and assay and requires urine
collection and administration of radioactive materials. The purpose of this study is to
evaluate two non-radioactive markers (iohexol and gadolinium) compared to urinary clearance
of inulin and iothalamate. The investigators hypothesize that plasma clearance of
non-radioactive markers will be unbiased compared to a gold standard and more precise than
currently used urinary clearance methods.

Trial ID

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Summary

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