Usage & Assay Information

Determined by its ability to chemoattract rat neutrophils using a concentration range of 10.0-100.0 ng/ml.

Storage & Safety

Storage

Store at 4 deg C until reconstitution. Following reconstitution aliquot and freeze at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.

Endotoxin Levels

Endotoxin level is less than 0.1 ng per ug (1 EU/ug).

General Information

Biological Significance

All three isoforms of GRO are CXC chemokines that can signal through the CXCR1 or CXCR2 receptors. The GRO proteins chemoattract and activate neutrophils and basophils. Recombinant rat GRO/KC is a 7.8 kDa protein consisting of 72 amino acids including the 'ELR' motif common to the CXC chemokine family that bind to CXCR1 or CXCR2.