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Indications:

•For short-term management (? 7 days) of different painful conditions that requires analgesia at opioid level e.g.: Major abdominal operations-Orthopaedic operations-Dental operations -Gynecological operations; Therapy should be initiated with IV or IM and continuation of treatment with oral Ketorolac, if necessary.
•For management of severe painful conditions e.g.: Cancer pain, Renal colic,........etc.
N.B.: The total combined duration of use of Ketorolac tromethamine is not to exceed ? 7 days because of potential increase of severity of adverse reactions associated with therapeutic doses. Patients should be switched to alternative analgesics as soon as possible. - As an eye drops: indicated to patients suffering from:
The temporarily relief of ocular itching due to seasonal allergic conjunctivitis.
Postoperative inflammation due to cataract extraction.

Contraindications:

Known hypersensitivity to ketorolac or other NSAIDs, history of asthma, severe heart failure, peptic ulcer, coagulation disorders, and during pregnancy and lactation.

Ketorelac should not be used with other NSAIDs and Probenecid because of the potential for additive side-effects.
*Ketorolac reduces the diuretic response to frusemide by approximately 20%, in renal impairment.
*Caution is advised when: Methotrexate or Lithium is administered concurrently with ketorolac.

Warnings:

•In elderly: Longer dosing interval is advisable.
•History of asthma: Bronchspasm may be precipitated.
•NSAIDs can cause: GIT irritation, ulcers or bleeding with or without a history of previous symptoms.
•Renal patients: patients with moderate to severe impairment of renal function should not receive ketorolac.
•Appropriate monitoring is required for patients with history of hypertension and/or congestive heart failure.
•Caution should be used where strict haemostasis is critical, e.g. in cosmetic or day-case surgery.