I reading that orsomucoid (alpha-1-acid glycoprotein) is the major carrier of positively charged (basic) drugs in the blood, while albumin carries negatively charged (acidic) and drugs with neutral ...

I have seen on the internet that prolonged steriod treatment can result in the development of steroid drug tolerance leading to decreased hormone secretion. In turn this may lead to drug dependence, ...

I have had a look at previous inhaled anesthetics and many of them appear to be fluorocarbons. What could be the mechanism behind fluorine's anesthetic properties? Is it the specific bonding pattern ...

They are nonselective cholinoblockers and antimuscarinic.
Other cholinoblockers of parasympaticus, which I know, are parasympatholytic such as atropine, butylscopolamine, trihexyphenidyl, titropium ...

Norepinephrine is less beta2 adrenomimetic than epinephrine so more selective so less bronchospasm so may be therofore better in treatment of cardiac failure and different shocks.
However, I am not ...

Assume you have a drug nebivolol.
When nebivolol is used as beta1 selective drug, beta2 is mostly for side effects, but this is not clear from PubChem.
I do not know any cases where nebivolol is used ...

I've researched quetiapine for quite some time now and I've found some references to tolerance, but nothing conclusive. My question is whether quetiapine use builds tolerance to the drug and if so, ...

I am reviewing some material on loop diuretics, and I am curious to know how these drugs are administered. Also, I am interested in knowing their time course of action once they are administered into ...

I read on a vitamin-D product (2000NE) that I should not use calcium and magnesium with it, because it can result crystal formation in the blood. I googled, but find anything about this. Is it true?
...

There's definitely something I'm missing here.
Since calories is a unit of measurement for energy, and caffeine seemingly gives you a lot, how can the labels on caffeinated products have such a low ...

Suppose there is a person that has never used nicotine in any form in his/her life. Why does the person get dizzy after a few "shots" from a cigar(nicotine)? What's the difference between using other ...

Backstory:
My girlfriend reacts heavily to chocolate and drinks containing stellar anise, in a way that seems comparable to psychedelic drugs.
After consuming it, it takes approximately five minutes ...

I was reading in my pharmacology textbook about fluorouracil, and my book mentioned that fluorouracil is an antimetabolite whose function is to inhibit pyrimidine synthesis. However, I was curious to ...

So I am taking a new class at my institution called Theoretic Nuclear Thermochemical Pharmacology, (I know big name, it's an elective from a real pioneering fronteirsman in our department :P) and I am ...

I am working in bioinformatics(part of it in Drug Designing) for years, still if I have no idea about it. As it is too hard to prove (Pass all Clinical trials) and get FDA Approvals.
So, My question ...

I'm curious to know if neurotransmitter degradation factors into drug tolerance and neural conduction and, if so, to what extent. As I recall from textbooks I read as an undergrad, one mechanism of ...

I have been reading a fascinating paper: Valproate reopens critical-period learning of absolute pitch
18 individuals were given Sodium Valproate (VPA) for a fortnight during which they trained on a ...

If this question is a little off topic for Biology, I'm sorry. I've recently read a lot about mesoporous silica nanoparticles as a promising drug delivery method. The huge range of customizability of ...