“In the spring of 2016, the sufferer pete took a big risk by reinstating a low dose of SSRI. While this seems like it could only make matters worse, there have been anecdotal reports from researchers noting that low doses of SSRIs have reversed persistent sexual dysfunction in adult rodents previously treated with SSRIs at a young age.”

To double check, I couldn’t find any studies about low dose ssri reversing sexual deficits from a young age on the Internet (hence it being anecdotal reports as mentioned above by Ghost) but my question is if somebody could explain why this could help? Something about stimulating neurosteroid production? I thought normal dose SSRI already stimulated more allopregnenalone neurosteroid production?

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My theory is if PSSD is a form of permanent or a protracted SRI withdrawal syndrome, then a low dose would stop the withdrawal state.

I've talked to people suffering from a semi-permanent, protracted DAWS (dopamine agonist withdrawal syndrome) whom a very low dose of Pramipexole helped stop the severe intolerable withdrawal. Doses as low as 0.0125 mg.

I'm not sure.

Like a robot attempting to fix its own faulty programming1. Fix the gut/hormones.2. Find a symptomatic relief not counteracted by homeostasis.3. Work on permanent solution through TrkB, BDNF, and NGF.4. Decrease microglia activation.

Im too lazy atm to track it down but the study on rats is linked somewhere here in the forums. When it first surfaced I had moonwife give it a good combing thru. In her medical opinion the study does not relate to our situation so it is a good chance that it is a dead end. Reasoning has to do with the SSRI being administered during a developmental state on the young rats, but same result not seen in adult rats given dose for the first time.

The why it may work in humans is up in the air.... too many what-ifs going on till we have figured out the true cause.

"healthy sexual function" depends on several neurotransmitters' working together.

SSRIs target all those systems; with highly serotonergic types having the worse effect on sexual function. At first it sounds simple... counteract each of those effects... boom we are cured. Obviously it hasn't been that simple.

Studies have shown lowering doses and adding things like yohimbine, ropinirole or amantadine, as well as different classes of antidepressants... mirtazapine, nefazodone, and bupropion can help in both rats and humans. That is for a person still taking the SSRI. So far using same approach on those of us that are off the SSRI is not showing same response.

Theoretically going back on a low doses and trying one those treatments could kick start things I guess. Then again.. theoretically we don't exist.

Comes down to this.... how bad has PSSD effected your sex life. If the answer is already destroyed it... not really a risk of making it worse huh?

Forget about serotonin ,ssri inhibits 3β-HSD at the same extent finasteride inhibits 5-alpha reductase both are key enzymes ,it's all about endocrine destruction...So a temporary inhibitions lead to a temporary remission of our symptomatology