The club's updated timeframe now rules the 31-year-old out of key Premier League fixtures against Manchester City and Chelsea, while his involvement in the derby with Arsenal on December 1 is also in doubt.

"Jan Vertonghen sustained a hamstring injury against Huddersfield Town on 29 September, which has been monitored closely over the past 12 days," read a Tottenham statement.

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"Further investigation has shown a good initial response to rehabilitation.

"The Belgium international defender will now continue his recovery with a view to returning to full training by December."

Vertonghen was an integral part of Belgium's run to the World Cup semi-finals and started each of Spurs' first seven Premier League fixtures this season.