Any sugesstions how to pressurize carb.?

I have a chevy Malibu 1978 twin turbo engine 327 ,with holley 750 doble pump mechanical secondary. but I'm having trouble when its running and when it receives boost it starts to have problems.I've tryed increasing and decreasing gas but no results.Is their a trick for the holley to get it running well:confused: .Please help Thanks