Since NOS isoforms are present in Leydig cells, we assumed that L-NAME, a non-selective NOS inhibitor, would block NO synthesis and, consequently, a possible basal nitrergic inhibition of purinergic currents.

The ulcer-healing activity of ECD was inhibited by pre-administration of the specific COX-1 inhibitor (SC560) and nonspecific NOS inhibitor (L-NAME), which indicates the involvement of PGE2 and NOS in ECD induced ulcer healing activity.

Each group received different combinations of the following drugs: bilberry extract, fluoxetine (Prozac), L-arginine and L-NAME which is an NOS inhibitor. Each group excluding the control group was subjected to stress for 21 days.

Although, studies using [Nk.sup.[omega]]-nitro-Larginine methyl ester (L-NAME), an NOS inhibitor to inhibit endogenous and exogenous NO production demonstrated that NO is essential for optimal meiotic maturation both in vitro and in vivo (Jablonka-Shariff et al., 1999).

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