Windows 10 Fall 2018 Update:Updating to the newest Windows 10 Fall update? Wacom has identified a few issues within the latest update. Pan/Scroll is not working correctly in some applications. Also, Modifier Clicks do not work when assigned to pen buttons or ExpressKeys, see the screenshot below. The Wacom driver team has submitted a bug report with Microsoft for these issues and will continue to work with them until it is fixed. More information can be found here: here

Mac OS 10.14 Mojave:Upgrading to Mac OS 10.14 Mojave? A new Mac OSX security feature requires some additional changes to run the Wacom Driver correctly. Please see the instructions found on our support page here. Also, If you have any issues, please try a clean driver install. Follow the steps here.

Thanks a lot. The problem wasn't the rotation lock greyed out, was just the button that wasn't turning it on and off. But actually it was you reading windows key on sharp keys that got me to the solution.

I had mapped left windows key to ctrl on sharp key, to keep my shortcuts similar to what I have in mac os. It's now solved. Thanks!