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It took a lot of research and experimentation before I could formulate my own nootropic stack. The Neurohacker Collective team took a similar scientific approach in creating Qualia Mind, a blend that supports mental performance and brain health. In this post, I review the science of its 28 ingredients and how they work to support brain function.

Qualia Science

Neurohacker Collective rigorously reviewed the scientific literature to formulate Qualia. And that’s exactly the approach I took to create my own stack a while back.

The brain is an extremely complex organ with many unique networks and connections. Cognition does not arise from just one part of the brain or biochemical reaction. It takes reading and analyzing many scientific studies (on humans whenever available, other times in animals), understanding how the brain works, and addressing the mechanisms.

It’s equally important to look at all the data together and understand how one thing affects another. Nothing in the brain happens in isolation. I realized several natural substances should be combined to affect most of the important pathways and processes in the brain. Any single substance, lifestyle, or dietary intervention won’t do the trick [R].

All the ingredients in Qualia have been individually researched and are safe. As long as each ingredient that goes into a supplement is generally safe, you don’t really need a clinical study to confirm the combined effects. This can be useful to understand synergies, but in the end it often depends on how each person will react.

Many SelfHacked readers struggle with brain fog and fatigue, problems originating in several areas and pathways in the brain. It takes many interventions to resolve them, including advanced supplements that target the underlying issues in the brain.

That’s why I was so curious about Qualia, which contains 28 ingredients that support brain health and cognition. I decided to review all of them, the research behind each ingredient and their synergies.

What is Qualia?

Qualia is a natural nootropic stack formulated by Neurohacker Collective, a San Diego-based company with a mission to create products that improve human performance by supporting our natural complex physiology rather than overriding it.

The mitochondria also initiate the production of steroid hormones, including cortisol and all sex hormones. That’s why malfunctioning mitochondria can cause hormone imbalances [R].

Another key function of the mitochondria is to commit cellular suicide — known as apoptosis — in response to excess stress, damage, or mutations. Evolutionarily, it is better for the damaged cells to commit suicide than to spread more oxidative stress, go on to damage other cells, or develop into cancers [R].

However, if too many cells commit suicide faster than the body can replace them, important tissues can start losing function. This is the case in Alzheimer’s disease, when brain cells commit suicide faster than the brain can compensate, which triggers and worsens symptoms [R].

Qualia contains several ingredients that work together to improve mitochondrial function. These include PQQ and ALCAR (Acetyl-L-carnitine). It has several other ingredients that also support the mitochondria by reducing inflammation and oxidative stress in the brain.

2) Reducing Brain Inflammation and Oxidative Stress

Excessive oxidative stress damages the mitochondria. Likewise, poor mitochondrial function increases oxidative stress, which can further damage the mitochondria and cells if left uncontrolled. However, controlled oxidative stress is sometimes beneficial — it’s needed for reactions that help immune cells kill off pathogens. Therefore, balance is key.

I believe that inflammation and oxidative stress, especially in the brain, are the most common causes of brain fog (cognitive dysfunction) and fatigue. Inflammation in the brain can shut down wakefulness-promoting orexins [R, R], while the oxidative stress can hamper and damage the mitochondria [R].

3) Enhancing Neuroplasticity and Learning

Neuroplasticity is your brain’s ability to change and adapt to various circumstances. This mental flexibility allows for new experiences and learning, while also compensating for traumatic experiences and injuries.

The main factors that increase neuroplasticity include Brain Derived Neurotrophic Factor (BDNF) and Nerve Growth Factor (NGF) [R, R]. Called neurotrophins, these growth factors help make new brain cells and connections. They help the brain better adapt to new challenges, reduce age-related cognitive decline, and prevent neurodegenerative diseases and depression [R].

Several Qualia ingredients work together boost the levels of these growth factors. These include PQQ, ALCAR, huperzine-A, Ginkgo biloba, curcumin, and rhodiola [R, R,R, R, R, R].

Energy production in the mitochondria requires sufficient oxygen to function well. As an organ that greatly depends on the mitochondria, the brain is exceptionally sensitive to oxygen levels. The blood that reaches the brain also brings glucose as its main fuel and removes waste.

The body has several sensors and mechanisms to maintain balance and ensure enough blood is pumped to the brain [R]. But poor circulation, high or low blood pressure, stress, oxidative damage, and lack of sunlight can all reduce brain blood flow [R, R, R, R].

Living at a high altitude, toxic mold syndrome, obstructed breathing, and anemia can reduce the amount of oxygen available to the brain. While this sub-clinically poor brain circulation and oxygen availability may not be life threatening, it can reduce cognitive function and contribute to the development of mental and neurological disorders [R, R].

To optimize your cognitive and mental capacity, the brain needs to be well-nourished. Several Qualia ingredients act together to improve blood flow to the brain. These include vinpocetine, Ginkgo biloba, citrulline, carnitine, ginseng, and bacopa.

Nerve communication uses electrical signals that resemble waves. Positively or negatively charged particles (ions) travel through the cell membranes either to enter or exit the cell, creating a current. Healthy cell membranes help properly pass signals, which is why they are critical for your nervous system to function optimally.

Myelin sheaths are insulating fat layers that wrap around the nerve endings and allow the nerve signals to jump rather than walk. As myelin sheaths speed up signal transmission, having more myelin makes you smarter and more agile.

6) Optimizing your Neurochemistry

Qualia helps optimize your neurochemistry by providing the essential building blocks, vital minerals and vitamins your body needs to produce all neurotransmitters and their levels balanced. These include DL-phenylalanine, choline, phosphatidylserine, and vitamins in this formulation.

Why the Qualia Formulation is More Effective?

1) Targeting Multiple Processes that Affect Brain Function

Your brain health depends on numerous factors, which is why improving cognitive function should involve a well-rounded approach. The scientists at Qualia mapped out all the factors that affect brain function to ensure that the formulation addresses them all.

2) Synergistic Ingredients

Synergy is when a combination of ingredients produce an effect greater than the sum of its parts. Most natural nootropics have more than a single positive effect and when you stack them together, some effects become stronger than if you had taken either one alone. Some well-known synergies include:

Caffeine and theanine, which together improve focus, visual attention, reaction time, alertness, simple and numeric working memory [R]

Uridine, choline, and DHA, which work together to improve synapse formation [R]

Forskolin and luteolin both increase cAMP, which enhances wakefulness, and boost the strength of cellular signaling within neurons [R, R]

Adaptogens, which help counter the harmful effects of stress and maintain performance during periods of increased stress. Qualia contains both stimulating and calming adaptogens, so it’s balancing and will not cause you to crash.

Qualia Ingredients

The current formulation of Qualia boasts 28 Ingredients, all in reasonably high dose. They transparently list all the ingredients. Here is a rundown of all the ingredients and how they work.

1) Alpha-GPC

Alpha-GPC is a natural cholinergic substance that can readily reach the brain to increase choline. acetylcholine, and to protect the neurons [R]. Alpha-GPC may even help with cognitive symptoms in people with stroke, senile dementia, and Alzheimer’s based on clinical studies [R, R].

Benfotiamine is a synthetic, more fat-soluble, and more potent version of vitamin B1 (thiamine). It is also a potent antioxidant and anti-inflammatory that protects the brain [R, R]. In a small clinical study, benfotiamine helped improve cognitive function in 5 Alzheimer’s patients [R].

Carnitine is a amino acid that boosts energy production. It helps turn fatty acids into energy using the mitochondria. Acetyl-L-Carnitine is particularly good for improving brain and cognitive function, since he acetyl group added to carnitine also increases acetylcholine in the brain [R, R].

6) Celastrus paniculatus Seed Extract

Celastrus is also known as the “intellect plant”. It improves cognitive function by increasing acetylcholine [R]. It also protects the neurons from oxidative damage and toxins. In rat studies, it reduced depression, anxiety, pain, and inflammation [R, R, R]. Plus, it might also support myelination [R].

7) Coffee Fruit Extract

Coffee fruit extracts contains a lot of antioxidant polyphenols, especially chlorogenic acid [R]. It contains much less caffeine than coffee beans. In a small pilot study, whole coffee fruit extract increased BDNF by 143%, suggesting that it can enhance cognition [R].

Chlorogenic acid also activates GABA-a receptors, which can reduce anxiety and increase acetylcholine levels by blocking the enzyme that breaks it down (acetylcholinesterase) [R, R].

8) Cognizin Citicoline

Citicoline, or CDP-Choline is made of choline and cytidine. Once CDP-Choline is broken down into choline and cytidine, the cytidine is converted into uridine [R]. Choline provides both the backbone of the neurotransmitter acetylcholine and also support myelination, along with uridine [R].

Although widely known as a weight loss supplement, forskolin is also a cognitive enhancer. It stimulates energy use by increasing cAMP, which increases energy production in every cell, including those in the brain [R]. In addition, it lowers inflammation and supports blood sugar control [R].

DHA is an important component of the myelin sheath and cell membranes in the brain. It’s used as an important building block for the nervous system and is also a strong anti-inflammatory [R]. DHA supplementation improves memory and attention, mood, and blood flow to the brain [R, R, R].

DL-phenylalanine is a mix of two forms of phenylalanine that are mirror images of each other. L-phenylalanine provides the chemical backbone for making dopamine, norepinephrine, and epinephrine. D-phenylalanine activates the opioid system by inhibiting enzymes that break down opioids [R]. D-phenylalanine also reduces stress and improves symptoms of depression [R, R]. The DL-phenylalanine mix enhances the communication between neurons by activating the AMPA receptors, which are important for learning and memory [R].

PQQ is a potent antioxidant and a coenzyme for the mitochondria. It increases the number of mitochondria, which is linked to longevity, improved energy use, and better antioxidant defense [R]. It also supports brain health by increasing NGF [R].

Phosphatidylserine is made by adding a phosphate group to the amino acid serine. It is an important component of the brain cell membranes, improves the communication between brain cells. It increases NGF activity while reducing cortisol in response to acute physical stress [R, R].

L-theanine is a calming amino acid commonly found in green tea. It increases alpha brain waves, which promotes attention and relaxation without causing the jitters or drowsiness [R]. It acts in synergy with caffeine to increase concentration, motivation and memory. Importantly, it can reduce the side effects of caffeine [R].

Theobromine is a caffeine-like substance from the cacao beans. It works similarly to caffeine, blocking the adenosine receptor, but is more gentle and lasts longer than caffeine [R]. It boosts cAMP, which increases cellular energy [R].

21) N-Acetyl-L-Tyrosine

N-acetyl-L-tyrosine is the amino acid tyrosine with an added acetyl group, which increases its ability to cross into the brain [R]. It’s used to make dopamine and noradrenaline, which helps us better deal with stress [R].

Uridine is a naturally occurring nucleic acid that has nootropic effects. It supports phospholipid synthesis, thus supporting myelination [R]. It functions as a neurotransmitter and also increases NGF and dopamine levels [R, R, R]. Uridine synergizes with choline, DHA, and other phospholipids, which are also present in this formula [R].

23) Vitamins B3, B5, B6, B12, C, and D3

Nicotinamide (vitamin B3) is part of the key energy production coenzymes called NAD+ and NADP+. It has anxiolytic and neuroprotective effects [R, R].

Calcium Pantothenate (synthetic vitamin B5) can improve concentration, memory, and learning [R]. It has a key role in using energy, making choline, and other cholinergic substances [R, R].

Pyridoxal-5-Phosphate (active vitamin B6) is essential for cellular energy production [R]. It improves the health of brain cells and aids the production of key neurotransmitters, such as acetylcholine, dopamine, serotonin, noradrenaline, and melatonin [R, R].

Methylcobalamin (vitamin B12) is an important cofactor for several enzymes. It helps provide the methyl group to homocysteine in the brain and turn it to SAMe [R]. It also improves memory and executive function [R] and the regeneration of neurons and their impulse-conducting endings (axons) [R, R, R].

Ascorbic Acid (vitamin C) is a natural neuroprotective antioxidant. It can help with fatigue and the production of hormones and neurotransmitters [R, R].

Cholecalciferol (vitamin D3) is converted to the active form, calcitriol, by the liver. Calcitriol then activates the vitamin D receptors, which are found in several regions of the brain [R]. It enhances brain communication and synaptic plasticity, and increases glutathione [R, R].

Potential Qualia Side Effects

Qualia has a caffeine-free formula (Qualia Mind Caffeine Free) for those who cannot handle caffeine. However, given the long list of ingredients, it is possible that some people will experience side effects.

Good Side Effects

While we didn’t mention throughout this post, the ingredients in Qualia have several positive side effects. Qualia can reduce heart disease risk and improve overall health due to the antioxidant effects components. Some other ingredients, such as forskolin and caffeine, may boost fat burning, while chlorogenic acid from coffee fruit extracts increases insulin sensitivity. Several ingredients, such as DLPA, curcumin, and rhodiola may even reduce pain.

Bad Side Effects

Common negative side effects include:

Headaches

Sleep disturbance, especially if it’s taken late in the day

Muscle tightness

Upset stomach

Fatigue

If you know that you react negatively to one of the ingredients in Qualia, then this product is not for you.

For example, one of our team members experiences negative mood changes in response to forskolin. She also experienced the same side effect with Qualia.

Who is Qualia For?

Qualia is created for hard-charging professionals who need to maximize cognitive function and do not have a lot of time to spend on improving brain health. It’s also formulated to help with brain fog or mild mood issues due to stress. Several of its ingredients can help with chronic pain, improve cardiovascular and overall health.

If you’re interested in improving your cognition and brain health, I highly recommend you try it. In addition, eating a healthy diet, good sleep, sufficient sun exposure, and regular exercise will synergize with Qualia and give you even better results.

Buy Qualia

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JOE COHEN

CEO, SelfHacked

About Joe

Growing up, Joe was plagued with a myriad of health issues such as gut problems, autoimmune issues, chronic fatigue, brain fog, insomnia, and general inflammation. Both conventional and alternative doctors weren’t able to help him, so he decided to fix himself. With lots of health questions and few satisfying answers, Joe decided to read every research paper he could get his hands on and conduct thousands of experiments on his own body in order to fix his health issues. Joe started SelfHacked in late 2013 when he successfully fixed all of his issues, and now it gets millions of readers a month looking to educate themselves about how they can improve their health. Joe is now a thriving author, speaker, and serial entrepreneur, founding SelfDecode & LabTestAnalyzer.

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