A witness video shows the horrifying moment an SUV driving the wrong way on a Florida freeway crashed into another car at high-speed and killed both the unidentified driver and all four college students in the other car.

Tampa resident Jada Wright posted the video to her Facebook following the early Sunday morning crash.

Wright starts filming the SUV driver as it barrels down I-275 in the wrong direction.

'What is he doing?' she says. 'He's on the wrong side.'

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'Where is he going?': A driver filmed a Florida car crash involving a wrong-way driver that killed five on Sunday

As the SUV speeds up ahead of Wright
on the opposite of the medium, she remarks: 'See, this is the right lane
- where is he going?'

Moments later, an explosion illuminates the roadway as the SUV crashes at around 55mph into another car.