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The Leading Edge of CBD Science

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18 March 2017

The Leading Edge of CBD Science
As explained in previous articles, cannabidiol (CBD) works because it interacts with the body’s endocannabinoid system (ECS). The ECS is very important to our health and wellbeing, its main function is to maintain homeostasis, that is stability of all our body’s processes and functions.

Using Love Hemp products as a food supplement nourishes your endocannabinoid system (ECS) and can help improve and maintain health. However, scientists are currently researching CBD in much higher doses for use as a medicine and this requires more detailed understanding.

What allows CBD to effectively treat so many conditions, and maintain health and wellness in the body, is how the cannabinoids found in CBD interact with receptors throughout our body.

Cannabidiol (CBD), a non-intoxicating component of the cannabis plant, has generated significant interest among scientists and physicians in recent years—but how CBD exerts its therapeutic impact on a molecular level is still being sorted out. Cannabidiol (CBD) is a pleiotropic drug in that it produces many effects through multiple molecular pathways. The scientific literature has identified more than 65 molecular targets of CBD.

But how does CBD oil science work? How does CBD work within the body? The key to answering these questions lies within the endocannabinoid system (ECS). Is this article we will take a look at the fascinating subject of CBD oil science, gaining information from the latest research.

What is the endocannabinoid system (ECS)?
“There is so much that’s still unknown about this system. It looks to be regulating every physiological system in the body,”

The endocannabinoid system (ECS) is a wide-ranging natural network of cannabinoid receptors that affect virtually all functions throughout the body. The ECS was only discovered in the early 1990’s and it’s still rarely discussed, even in medical schools.

The endocannabinoid system (ECS), which is found in all mammals, is tasked with regulating mood, appetite, sleep, hormone production, and even stress and immune system responses. This complex system is regularly adjusting these functions in an effort to keep them in balance or homeostasis.

Ever since the first cannabinoid receptor was identified, the field has been overwhelmingly focused on the central nervous system. The main cannabinoid receptor, CB1, was first

discovered in a rat brain and is now known to be among the most abundant G protein–coupled receptors in neurons there. Plus, cannabis is well-known for its psychotropic effects.

But recent work has provided evidence that the endocannabinoid system (ECS) isn’t exclusive to the brain. It is present everywhere in the body that scientists have looked: the heart, liver, pancreas, skin, the gut, reproductive tract, you name it. And disrupted endocannabinoid signaling has been associated with many disorders, including diabetes, hypertension, infertility, liver disease, and more.

Cannabinoid receptors.
Now we have established the role of the endocannabinoid system (ECS) let’s take a more detailed look at the receptors within this system.

The ECS consists of endocannabinoids and cannabinoid receptors. Cannabinoids interact with different cannabinoid receptors in the body, sometimes in tandem and sometimes in competition.

Receptors are membranes in our body’s cells that enable signals to be passed back and forth, so CBD affects these signals either by stimulating them or blocking them.

The most well known cannabinoid receptors, CB1 and CB2, are proteins that are imbedded in the membrane of cells. These surface proteins are then attached to another protein that determines the signaling direction: activation or inhibition. The signal that goes out will depend on which molecule (THC, for example, will activate, while CBD inhibits) that binds to the receptor. There are, however, other receptors in the human body that are activated by cannabinoids.

The main difference between these two receptors is in their distribution throughout the body: CB1 is mostly found in neurons within the brain whereas CB2 is mainly expressed on immune cells, including those of the brain, with lower numbers in the central nervous system.

A more recently discovered cannabinoid receptor is GPR55. GPR55 is localised to the central nervous system, expressed in the hypothalamus, thalamus, and midbrain.

Another type of cannabinoid receptor is PPARg, which operates completely differently compared to CB1, CB2 and GPR55. It belongs to a nuclear hormone receptor family, which, when activated, makes alterations at the level of gene expression. It has been detected in many tissue types, including muscle, brain and in immune cells. The endocannabinoid anandamide has been shown to interact with PPARg.

The endocannabinoid system (ECS) really is a fascinating subject and, as more research is carried out, scientists are certain it will be established as one of the most important systems within the body.

Clinical endocannabinoid deficiency.

Interestingly, researchers believe that some illnesses may actually be caused by an underlying endocannabinoid deficiency.

The theory of clinical endocannabinoid deficiency, which was first proposed by researcher Dr. Ethan Russo, suggests that in some cases the body doesn’t produce enough endocannabinoids or enough receptors for the endocannabinoid system (ECS) to function properly. As a result, the many functions aren’t regulated properly and the body becomes unbalanced, allowing diseases to develop.

While more research needs to be done before endocannabinoid deficiency can be proven, the theory could open the door for methods to prevent and manage certain conditions. Dr. Ethan Russo believes cannabinoids from cannabis plants like hemp are essential nutrients that can minimise illness by assisting the endocannabinoid system (ECS) and ensuring that it functions properly.

Cannabinoids found in plants like cannabis and hemp, including cannabidiol (CBD), are similar to the endocannabinoids naturally produced by the body. The latest CBD oil science shows that they interact with the cannabinoid receptors of the endocannabinoid system (ECS) the same way our bodies own natural endocannabinoids do.

The very latest CBD oil science research suggests that enzymes within the ECS may be able to convert cannabinoids such as CBD into other cannabinoids which the body needs. So if your endocannabinoid system (ECS) is deficient in some way, the CBD you take as a food supplement may be converted to make up for a lack of one or more endocannabinoids.

This is the key – regular, moderate consumption of CBD works in a gentle and subtle way to enhance the body’s natural processes. Once you have found the way of consuming CBD that fits in with your lifestyle, it becomes a regular part of your health and fitness regime.

How can taking CBD oil improve health and wellbeing?Regularly supplementing your diet with CBD oil or cooking with CBD oil can be beneficial for your health in many ways.

Here are just a few of the benefits of taking CBD:
● CBD oil helps to promote homeostasis or balance.
● It can help improve mood.
● CBD can protect us from all forms of illness.
● It may improve our fitness results and aid recovery.
● CBD oil can protect us from the damaging effects of stress.
● It promotes cognitive function.
● CBD Provides a good source of essential nutrients.
● It can combat clinical endocannabinoid deficiency.

Using CBD as a food supplement is not a treatment for medical conditions but as with other supplements, its long term effect may be preventative, just as ensuring regular intake of vitamins and minerals can prevent disease and illness.

Similarly, many people find benefit from taking regular doses of vitamin C. Our body does not manufacture it internally and it has to come from food or supplements. Just like CBD, any excess passes safely through our body but regular consumption means it is always available when needed.

Love Hemp CBD products

At Love Hemp we offer a wide selection of high quality CBD products. Whether you are looking for a CBD oil, capsules, E-liquids or edibles, we have an effective option for your specific health requirements.

Remember, if you don’t like taking capsules or oil, CBD can always be incorporated into food. You can bake it in cakes or just add a few drops of oil to coffee or in a casserole. In fact, there’s very little that is better for you than a salad dressing made with hemp seed oil, crushed hemp seed and some CBD, that really is a health food packed with goodness and nourishment.

With the latest research into CBD oil science it is apparent that CBD oil it is an amazing treatment for anyone who just generally wants to achieve a healthier, more active lifestyle, and improve their quality of life and general wellbeing.

Taking CBD oil is the easiest and most effective way to help boost your body’s natural endocannabinoids and potentially correct a deficiency or imbalance. Just like a multivitamin supplement, it is recommended that you take CBD oil regularly to maximise the benefits you receive.

More than ever before, people are choosing to take CBD as a daily supplement and you should too.

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