Clinical Question: Does the “metabolic cocktail” improve 28 day mortality in patients with sepsis and septic shock in comparison to placebo?

Author Conclusion: “Among patients with sepsis or septic shock, the combination of hydrocortisone, vitamin C, and thiamine did not reduce mortality compared with placebo.”

Clinical Take Home Point: This single center, small study doesn’t really add much to our knowledge of the metabolic cocktail in sepsis. The 28-mortality difference goal of 30% was too large and most likely confirms the methodologically flawed before and after Marik study results were overstated."