Kate Spade had a vision of a stylish new kind of handbag. Her husband, Andy, helped make it a reality. From 1993, the couple grew Kate Spade LLC into a household name—Ms. Spade took care of the designs, and Mr. Spade managed branding and advertising. In 1998, the couple sold 56% of the company to Neiman Marcus Group Inc., but stayed on to creatively direct it. They sold the rest of the company, and gave up directing the line, in 2007.

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Rachel and Andy Berliner
Redux

Andy and Rachel Berliner Founders of Amy's Kitchen Inc.

Andy and Rachel Berliner, who named Amy's Kitchen Inc. after their baby daughter, found a rewarding niche in creating healthy frozen meals. The couple work together closely as a team, saying they make all major decisions together. Beyond that, they have distinct roles at Amy's Kitchen: Mr. Berliner runs the company and directs its sales strategy, while Ms. Berliner heads up the art direction and serves as official taster for new products.

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Stewart and Lynda Resnick
Associated Press

Lynda and Stewart Resnick Owners of Fiji Water

Lynda and Stewart Resnick have steered some big brands, including Teleflora LLC and PomWonderful LLC (which has run into legal troubles with the Federal Trade Commission, a situation the company says is "unwarranted"). When they bought Fiji Water in 2004, it was sold mostly at hotels and high-end restaurants. Mr. Resnick took hold of manufacturing and operations; Ms. Resnick, marketing and advertising. Now Fiji is sold far and wide.

Linda Bloodworth-Thomason and Harry Thomason have made a name for themselves in Democratic Party circles, but the couple is probably best known for their string of popular television series, such as "Designing Women" and "Evening Shade." At Mozark Productions, Ms. Bloodworth-Thomason creates and writes the shows, while Mr. Thomason produces and directs.

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