5
Slide 5 USTUR: Learning from Plutonium and Uranium Workers USTUR’s Voluntary Tissue Donors To date, 327 previous workers with actinides (plutonium, americium and/or uranium) have voluntarily donated their tissues for scientific research – including 36 whole-body donors – from various weapons or other sites (not just Hanford). These donors, and a further 93 living Registrants with documented accidental exposures to actinide elements, voluntarily released their employment, occupational exposure histories and medical records. Each individual donor’s autopsy examination results, together with USTUR’s subsequent measurements of the actinide contents of tissues and major organs provide a unique collection of scientific data which encompasses all types of accidental exposure to actinides over the history of U.S. nuclear materials production and handling. The privacy of each donor is rigorously protected – and USTUR’s research protocols must be approved annually by WSU’s independent Institutional Review Board (IRB).

31
Slide 31 USTUR: Learning from Plutonium and Uranium Workers Application of USTUR 40-y Follow-up of U.S. Actinide Workers to Ensure Safe DOE/EM Site Clean-up Tony, Welcome home and thank you for keeping me well-informed regarding your activities. I wanted to let you know that [DOE is actively concerned with the] potential for [worker] radiological exposures in combination with silica, asbestos, and beryllium in the course of the D and D activities spurred by the 6 billion in stimulus funding. We have drafted a memo specifying continued compliance with DOE's health and safety requirements ………………………………. I will take every opportunity to suggest that USTUR is helping us understand more clearly the lessons of the past and supporting the development of hazard controls which may offset the exposures associated with the anticipated increase in activity by EM in particular. Thank you again, Mike April 16 th, 2009 Message to USTUR from Dr. Michael Ardaiz, DOE’s Chief Medical Officer

36
Slide 36 USTUR: Learning from Plutonium and Uranium Workers In Summary: U.S. Pu Workers c.f., MAYAK USTUR provides individual life-time follow-up of “at risk” – i.e., known actinide-exposed – U.S. workers. With relatively few exceptions, USTUR’s “at risk” cohort of Pu workers were exposed well below the contemporary “dose limits” – i.e., at levels that are RELEVANT to occupational exposure in a REGULATED workplace (and HIGHER than MIGHT conceivably be received by a member of the U.S. public). To find the health outcomes (effects on tissues) – OR LACK THEREOF – AND LONGEVITY at these (relevant) levels of exposure we need to work with a well-characterized “at risk” cohort, i.e., USTUR Registrants. Health outcomes that “jump out” of USTUR study are INDUSTRIAL RELATED – NOT Pu-related!!

37
Slide 37 CCHPS MAYAK Symposium, Apr 17 th, James Disclaimer: “This presentation was prepared as an account of work sponsored by an agency of the United States Government. Neither the United States Government nor any agency thereof, nor any of their employees, makes any warranty, expressed or implied, or assumes any legal liability or responsibility for the accuracy, completeness, or usefulness of any information, apparatus, product, or process disclosed, or represents that its use would not infringe privately owned rights. Reference herein to any specific commercial product, process, or service by trade name, trademark, manufacturer, or otherwise does not necessarily constitute or imply its endorsement, recommendation, or favoring by the United States Government or any agency thereof. The views and opinions of authors expressed herein do not necessarily state or reflect those of the United States Government or any agency thereof.”