That middle panel where Twilight and Pinkie are, for once, sharing the same thought.

I can almost hear the dialogue: "Pinkie! Are you pondering what I'm pondering? "I think so, Twilight. But how are we going to get a cat to wear toast?" "That is where you come in, my silly, reality-warping friend."

They're Pinkie and the brain. They're Pinkie and the brain. One is a genius, the other's insane. They're psychotic ponies, they're genes have been spliced. They're Pinkie, they're Pinkie and the brain brain brain brain brain brain brain brain BRIAN.

Before the night is done, their plane will be unfurled. By the dawning of the sun, they'll take over Equestria! They're Pinkie, yes, Pinkie and the brain. With Twilight's campaign, she easily explains. To prove their pony work, they'll overthrow Celestia. They're Pinkie, they're Pinkie and the brain brain brain brain brain brain brain brain