Anxiety/OCD:

Indications for EFFEXOR XR:

Adult:

Take with food. Swallow whole or sprinkle contents on spoonful of applesauce; do not chew. GAD: Initially 75mg once daily; may start at 37.5mg once daily for 4–7 days before increasing to 75mg/day; may increase by increments of up to 75mg/day at intervals of at least 4 days. SAD: 75mg once daily. PD: Initially 37.5mg once daily for 7 days, then may increase to 75mg/day; then may increase in increments of up to 75mg/day at intervals of at least 7 days. For GAD or PD: usual max 225mg/day. Mild-to-moderate hepatic impairment: reduce by 50%. Renal impairment: reduce by 25–50%; reduce dose by 50% in hemodialysis (hold dose until end of treatment). Withdraw gradually (reduce by 75mg/day at 1-week intervals).

Children:

Not established.

Contraindications:

During or within 14 days of MAOIs (see Interactions). Concomitant linezolid or IV methylene blue.

Metabolism:

Elimination:

Generic Availability:

How Supplied:

Pricing for EFFEXOR XR

Mood disorders:

Indications for EFFEXOR XR:

Major depressive disorder.

Adult:

Take with food. Swallow whole or sprinkle contents on spoonful of applesauce; do not chew. Transferring from immediate-release: give total daily dose on once-daily basis. Initially 75mg once daily; may start at 37.5mg once daily for 4–7 days before increasing to 75mg/day; may increase by increments of up to 75mg/day at intervals of at least 4 days; usual max 225mg/day. Mild-to-moderate hepatic impairment: reduce by 50%. Renal impairment: reduce by 25–50%; reduce dose by 50% in hemodialysis (hold dose until end of treatment). Withdraw gradually (reduce by 75mg/day at 1-week intervals).

Children:

Not established.

Contraindications:

During or within 14 days of MAOIs (see Interactions). Concomitant linezolid or IV methylene blue.