The Chemistry Department has three types of courses available
for students starting out toward careers in any of the sciences, engineering, or medicine. Students are placed into these courses
according to the results of the tests in chemistry and mathematics that they take during orientation.

For students interested in the sciences, engineering or medicine, either Chem. 130 or Chem. 210/211 can be their starting point.
Students who have had a strong course in high school (which may
include AP credit in chemistry) are advised to start in Chem.
210 and 211, the laboratory course that accompanies it. Chem.
130 is recommended for all other students. Section 400 of Chem.
130 is reserved for students who would benefit from a smaller
lecture section and more frequent contact with both senior faculty
and teaching assistants.

Students who have had little or no laboratory work in high
school should plan to elect Chem. 125 with Chem. 130. Other students
electing Chem. 130 may postpone laboratory to a subsequent term.

Laboratory Check-in

Check into labs on the first day they are scheduled. You must
take a print-out of your class schedule to Lab Check-in. If you
fail to appear, your space may be given to a waitlisted student
2 hours after the lab begins. You are at risk of having to waitlist
for another lab.

Chem 125, 211 and 216 Laboratory Waitlist

Prior to the first day of class, check for openings at CRISP
first. Fill out Waitlist Form in 1500 Chemistry. Go to Room 1706
Chemistry to get into labs 2 hours after desired lab begins. Sections
will be assigned there; student will take override to Chem Lab
to check in immediately. You will be registered automatically
into the section(s) shown on the override.

105/AOSS 105. Our Changing
Atmosphere. (3). (NS). (BS).
This course considers the science needed to understand human-induced threats to the atmospheric environment, with special emphasis
on the global changes that are taking place, or are anticipated.
We will discuss the greenhouse effect (and its impact on climate), ozone depletion, the polar ozone holes, and urban air pollution.
Some basic meteorology will be presented, including how climate
changes might affect the frequency and severity of hurricanes
and tornadoes. Students will have access to real-time weather
information via computer. This lecture course is intended for
non-science concentrators, and there are no prerequisites. Grades
will be based on three one-hour exams (no final exam) and homework.
Cost:1WL:1
(Samson/Wu)Check
Times, Location, and Availability

125. General and Inorganic
Chemistry: Laboratory. To be elected by students
who are eligible for (or enrolled in) Chem. 130. No credit granted
to those who have completed Chem. 211. (2). (NS). (BS). Laboratory
fee ($60) required.
This laboratory course can be elected with, or following, Chem.
130. It is intended that students planning to enroll in Chem.
130 that have had little or no previous chemistry laboratory enroll
concurrently in Chem. 125. The focus of this guided inquiry laboratory
is to foster critical thinking that allows students to design, perform, and interpret experiments. In addition, the student acquires
technical skills that are required for further advancement in
experimental sciences. Although an ability to collect and analyze
data in a quantitative manner is developed, the emphasis of the
course is to provide a qualitative understanding of the basic
concepts of chemistry. This is accomplished by demonstrating that
chemical principles are derived from experimental data. The goal
is to provide students both with a more accurate picture of the
scientific process and also with skills that are relevant to solving
real life problems. Much of the course work is done as a member
of a team. Student groups each explore the same problem with each
group using different reagents and/or conditions. A networked
computer system is used to collect, pool, and summarize the largely qualitative class data. Student groups address questions
which require them to organize the class data using commercial
graphing software. Group answers are presented in discussion.

The format of the course is organized into three sections.
Pre-laboratory reading and questions are completed prior to each
multi-period project laboratory. A one-hour lecture provides support
for the topics and problems that will be investigated in the laboratory.
The second component is performance in the laboratory where team
data are shared, analyzed, and evaluated. The third begins in the first hour following completion of each multi-period project
lab where groups communicate their findings during a student-led
discussion. There are two one-hour written examinations, scheduled
for Tuesday evenings, that constitute 30% of the grade. The remaining
70% of the grade is based on the points acquired in laboratory.
Refer to the Time Schedule for examination dates and times. Cost:2WL:2 (Kerner)Check
Times, Location, and Availability

130. General Chemistry:
Macroscopic Investigations and Reaction Principles. Three
years of high school math or Math. 105; one year of high school
chemistry recommended. Placement by testing, or permission of
Chemistry department. Intended for students without AP credit
in chemistry. (3). (NS). (BS). (QR/2).
This General Chemistry course is intended to satisfy the one-term
chemistry requirement for students interested in science, or as
a natural science elective for non-science concentrators. This
course may also be used as the first term in a four or more term
chemistry sequence (probably 130, 210/211, 215/216, 260/241/242, etc.) for science concentrators and pre-professional
students.

Chemistry 130 provides an introduction to the major concepts
of chemistry, including the microscopic picture of atomic and molecular structure, periodic trends in the chemical reactivity, the energetics of chemical reactions, and the nature of chemical
equilibria. Students will be introduced to the fundamental principles
of modern chemistry, the descriptive chemistry of the elements, and to the underlying theories that account for observed macroscopic
behavior. In Chem 130, students will learn to think critically, examine experimental data, and form generalizations about data
as chemists do. Chem 130 will meet three times each week in lecture
sections with senior faculty (the intensive section will have
four lectures a week), and once a week in small group discussion
classes led by graduate student instructors. Lecturers and graduate
student instructors will have scheduled office hours for after-class
help, and computerized study aids will be available to all students.
Course grades will be determined from discussion class evaluation, three one-hour examinations (Tuesday nights), and a final examination.
See Time Schedule for examination times and dates.

The intensive lecture section (Section 400) is intended for those students who would benefit from a smaller lecture section
(maximum 100 students) and more lectures so that the pace is slower
and there is more feedback. Placement by LS&A testing or permission
of the Chemistry Department (1500 Chemistry) is needed for enrollment
in this section. Cost:4WL:2 (Section
100: Kopelman;
Sections 200, 500: Lohr;
Section 300, 400: Weathers;
Section 600: Staff)Check
Times, Location, and Availability

210. Structure and Reactivity
I. High school chemistry. Placement by examination
during Orientation. To be taken with Chem. 211. (4). (NS). (BS).
Chemistry 210 is the first course in a two-term sequence in which the major concepts of chemistry are introduced in the context
of organic chemistry. Emphasis is on the development of the capacity
of students to think about the relationship between structure
and reactivity and to solve problems in a qualitatively analytical
way. This course is a particularly good first course for students
with AP credit in chemistry, Honors students, and other students
with a strong interest in chemistry and biology. The course has three lectures with the professor and one hour of discussion with
a graduate student instructor per week. There are three hour examinations
(Tuesday nights) and a final examination. See Time Schedule
for examination times and dates.

NOTE: This course is linked to Chemistry 211. The recitation
sections for Chemistry 210 and the corresponding laboratory sections
for Chemistry 211 are listed together in the Time Schedule
under Chemistry 210. Students must elect both Chemistry 210 (for
4 credits) and Chemistry 211 (for 1 credit). Cost:3WL:2 (Section
100: Lawton;
Section 200: Roush;
Section 300: Ashe)Check
Times, Location, and Availability

211. Investigations in
Chemistry. To be taken with Chem. 210. (1). (NS).
(BS). Laboratory fee ($67.50) required.
Chemistry 211 is a laboratory introduction to methods of investigation
in inorganic and organic chemistry. Students solve individual
problems using microscale equipment and a variety of techniques
such as thin layer chromatography, titrations, and spectroscopy.
The course consists of a four-hour laboratory period with a graduate
student instructor under the supervision of the professor. Students
keep laboratory notebooks, which also serve as laboratory reports.
Grades are based on performance in the laboratory and the laboratory
notebooks.

NOTE: This course is linked to Chemistry 210. The recitation
sections for Chemistry 210 and the corresponding laboratory sections
for Chemistry 211 are listed together in the Time Schedule
under Chemistry 210. Students must elect both Chemistry 210 (for
4 credits) and Chemistry 211 (for 1 credit). Cost:1WL:2 (Wiseman)Check
Times, Location, and Availability

215. Structure and Reactivity
II. Chem. 210/211. To be taken with Chem. 216. (3).
(NS). (BS).
The emphasis on thinking about structure and reactivity of organic
molecules started in Chemistry 210 is continued in Chemistry 215.
A major part of the course deals with carbonyl compounds (aldehydes, ketones, and carboxylic acid derivatives) and aromatic compounds.
Emphasis is placed on functional-group transformations, mechanism
and synthesis. If time permits, large molecules of biological
importance such as carbohydrates and proteins will be covered.
The course has three examinations and a final examination.

NOTE: This course is linked to Chemistry 216. The laboratory
sections for Chemistry 216 are listed in the Time Schedule
under Chemistry 215. Students must elect both Chemistry 215 (for
3 credits) and Chemistry 216 (for 2 credits). Cost:1WL:2 (Section
100: Staff; Section 200: Gung)Check
Times, Location, and Availability

216. Synthesis and Characterization
of Organic Compounds. Chem. 210/211. Must be taken
with Chem. 215. (2). (NS). (BS). Laboratory fee ($62.50) required.
Chemistry 216 builds on the experimental approach started in Chemistry
211. Students participate in planning exactly what they are going
to do in the laboratory by being given general goals and directions that have to be adapted to fit the specific project they will
be working on. They use microscale equipment, which requires them
to develop manual dexterity and care in working in the laboratory.
They also evaluate the results of their experiments by checking
for identity and purity using various chromatographic and spectroscopic
methods. Students will be expected to keep a laboratory notebook that will serve as the basis for their laboratory reports.

NOTE: This course is linked to Chemistry 215. The laboratory
sections for Chemistry 216 are listed in the Time Schedule
under Chemistry 215. Students must elect both Chemistry 215 (for
3 credits) and Chemistry 216 (for 2 credits). Cost:2WL:2 (Koreeda)Check
Times, Location, and Availability

218. Independent Study
in Biochemistry. Permission of instructor. For students
with less than junior standing. (1). (Excl). (INDEPENDENT). May
be repeated for a total of four credits.
This course provides an introduction to independent biochemistry
research under the direction of a faculty member whose project
is in the biochemistry area. The Chemistry Department encourages
students to get involved with undergraduate research as early
as possible. The Chemistry Advising Office, 1500 Chemistry, provides
information to help students in meeting with faculty members to
discuss research opportunities. Chemistry 218 is for biochemistry
concentrators, and research projects must be approved by a biochemistry
advisor. Exact details such as nature of research, level of involvement
of the student, and criteria for grading are individually determined
in consultation with the faculty member. The student is expected
to put in a minimum of three hours per week of actual work for
a 14-week term for each credit elected. At the end of each term, three copies of a written report are submitted – one for the Advising
Office, one for the student, and one for the faculty supervisor.

For a student to receive biochemistry credit for Chem 218, the student must work on a research project supervised by a member
of the biochemistry concentration research faculty, and the project
must be approved by a biochemistry advisor. Final evaluation of the research effort and the report, as well as the grade for the
course, rests with the biochemistry research faculty member. Cost:1WL:3Check
Times, Location, and Availability

219. Independent Study
in Chemistry. Permission of instructor. For students
with less than junior standing. (1). (Excl). (INDEPENDENT). May
be repeated for a total of four credits.
Research in an area of interest to, and supervised by, a Chemistry
faculty member. The Chemistry Department encourages students to
get involved with undergraduate research as early as possible.
The Chemistry Advising Office, 1500 Chemistry, provides information
and help to students in meeting with faculty members to discuss
research opportunities. Exact details such as nature of the research, level of involvement of the student, credits awarded, and criteria
for grading are individually determined in consultation with the
faculty member. The student is expected to put in at least three
hours a week of actual work for a 14-week term for each credit
elected. At the end of each term, three copies of a written report
are submitted – one for the Advising Office, one for the student, and one for the faculty supervisor.

For a student to receive Chemistry credit for Chemistry 219, the student must work on a research project supervised by a faculty
member of the Chemistry Department, either alone, or in collaboration
with a colleague within the department, from another department, or from another school. This collaboration must be an ongoing
one, and the student must receive direct supervision by all of the faculty who have agreed to sponsor the project. Final evaluation
of the research effort and the report, as well as the grade for the course, rests with the faculty member from the Chemistry Department.
Cost:1WL:3Check
Times, Location, and Availability

230. Physical Chemical
Principles and Applications. Chem. 215/216. No credit
granted to those who have completed or are enrolled in Chem. 260.
No credit granted to those who have completed Chem 340. (3). (NS).
(BS).
This Chemistry course is intended as a fourth term in chemistry
for science concentrators and pre-professional students, completing the two-year chemistry sequence required by, for example, the
medical, dental, and engineering programs. Students who plan to
continue beyond a fourth term in chemistry would typically enroll
in Chemistry 260/241/242 instead of Chemistry 230; credit will
not be given for both of these courses. In Chemistry 230, students
will be introduced to the physical principles underlying some
of the major topics of inorganic and analytical chemistry. We
will study the liquid and solid states of matter, phase transitions, solutions, electrochemistry, coordination complexes, spectroscopy, and the principles of thermodynamics that explain observed chemical
behavior. These topics will be treated from the viewpiont of the
experimental scientist, with an emphasis on the application of
physical chemical principles to chemical behavior in a broad spectrum
of settings. Chemistry 230 will meet three times each week in
lecture sections with senior faculty and once a week in small
group discussion classes led by graduate student instructors.
Lecturers and GSIs will have scheduled office hours for after
class help, and computerized study aids will be available to all
students. Course grades will be determined from three one-hour
examinations. See Time Schedule for examination times
and dates. Cost:2WL:2 (Sharp)Check
Times, Location, and Availability

241. Introduction to
Chemical Analysis. Prior or concurrent enrollment
in Chem. 260. No credit granted to those who have completed Chem.
340. (2). (NS). (BS).
Chemistry 241 is a continuation of Chemistry 130, 210/211, and 215/216, and is designed primarily for students in the biological
and chemical sciences. The course introduces students to the chemical
basis of both classical wet analysis methods and modern instrumental
analysis methods. The emphasis is on statistical methods and the
analytical applications of equilibria, electrochemistry, spectroscopy, and radioactivity. Analytical applications are further developed through the laboratory (Chemistry 242). Grading is based on hour
exams, problem sets, and a final examination. (Gordus)

242. Introduction to
Chemical Analysis Laboratory. Prior or concurrent
enrollment in Chem. 260. No credit granted to those who have completed
Chem. 340. (2). (NS). (BS). Laboratory fee ($50) required.
Chemistry 242 is the laboratory component of the Chemistry 241/242
course sequence. Experiments include studies of equilibria (titration, potentiometry), separations (gas and liquid chromatography), electrochemistry, and spectroscopy (atomic and molecular absorption and emission).
Grading is based on laboratory reports and a final examination.

260. Chemical Principles.
Chem. 215/216, Math. 115, and prior or concurrent
enrollment in Phys. 140. No credit granted to those who have completed
Chem. 340. (3). (NS). (BS).
Chemistry 260 is a continuation of Chemistry 130, 210/211, 215/216, and is designed primarily for students in the biological and chemical
sciences. The course introduces students to the quantal nature
of matter (the Schrödinger equation and the mathematical
machinery of quantum mechanics), the basic principles of chemical thermodynamics (1st and 2nd laws of thermodynamics) and kinetics
(empirical rate laws). In addition, this course introduces students
to the fundamental principles necessary to understand spectroscopy
(electronic, vibrational, and rotational) and electrochemistry
(free energy, Nernst and Faraday's laws). Grading is based on
hour exams, problem sets, and a final examination. Section 100:
Cordes;
Section 200: Sension)Check
Times, Location, and Availability

261. Introduction to
Quantum Chemistry. Chem. 215/216, Math. 115, and prior or concurrent enrollment in Phys. 140. Chem. 261 is intended
primarily for Chemical Engineering students. No credit granted
for students that have completed or are enrolled in Chem. 260.
No credit granted to students who have completed Chem. 340. (1).
(Excl). (BS).
Chemistry 261 is an introduction to the quantal nature of matter
(the Schrödinger equation and the mathematical machinery
of quantum mechanics) and the fundamental principles necessary
to understand spectroscopy (electronic, vibrational, and rotational).
Chemistry 261 is intended for Chemical Engineering students. This
course, together with Chem Engin 330, provides the prerequisites
necessary for enrollment in Chemistry 302. Grading is based on
problem sets and one hour exam. Chemistry 261 meets only for the
first third of the term. (Cordes,Sension)Check
Times, Location, and Availability

302. Inorganic Chemistry:
Principles of Structure, Reactivity, and Function. Chem.
260 (or Chem. 261 and ChemE 330; or Chem. 340). (3). (NS). (BS).
This course in Inorganic Chemistry is intended to introduce students
to the properties of the elements and the compounds that they
form. The course should be elected by students concentrating in
chemistry, chemical engineering, or cellular and molecular biology.
Section 100 will have a biological flavor and Section 200 will
have a materials flavor.

This course will provide an introduction to the structure and properties of those elements other than carbon. Topics that will
be included are the electronic structure of atoms, molecules and extended solids, bonding, periodicity, main group and transition
element chemistry, catalysis and bioinorganic chemistry. Several
lectures in the materials-oriented section will be devoted to
novel and emergent concepts and phenomena, such as, for example, ceramic superconductors, fundamental and applied chemistry of
organometallics, inorganic polymers, and materials chemistry.
The biological section will include examples of metals in proteins
and nucleic acids and how these metals are involved in biological
catalysis. Chemistry 302 will meet for one hour, three times each
week with a senior faculty member and once a week with a graduate
student instructor in groups of approximately 25. Lecturers and GSIs will have scheduled office hours. Course grades will be determined
from weekly problem sets, three one-hour in class exams, and a
final examination. See Time Schedule for examination
times and dates. Cost:3WL:2 (Section
100: Pecoraro;
Section 200: B. Evans)Check
Times, Location, and Availability

312. Synthesis and Characterization.
Chem. 215/216. Prior or concurrent enrollment in
Chem. 302. (2). (Excl). (BS). Laboratory fee ($70) required.
Chemistry 312 introduces students to advanced techniques used
in the synthesis, purification, and characterization of inorganic
and organic compounds. The course emphasizes methods for handling
air-sensitive material such as organo-metallic compounds, and includes syringe techniques, working under vacuum or inert gas
atmospheres, vacuum distillations as well as various chromatographic
and spectroscopic techniques. The course meets in two 4-hour laboratory
periods. Some of that time may be used for discussion of techniques
and principles. Grades are based on laboratory performance, written
reports, and examinations. Cost:2WL:2 (Coucouvamis)Check
Times, Location, and Availability

398. Undergraduate Research
in Biochemistry. Junior standing, and permission
of a biochemistry concentration advisor and the professor who
will supervise the research. (1-4). (Excl). (INDEPENDENT). May
be repeated for a total of four credits during junior or senior
year.
Elected starting in the junior or senior year, this course is
an optional requirement for Biochemistry students and a requirement
for Honors Biochemistry students, who must elect it for a total
of four credits spread out over two or more terms. The student
is expected to put in a minimum of three hours a week of actual
work for each credit elected. At the end of each term, a written
report evaluating the progress of the project is submitted; one
copy to the faculty member, one copy for the Chemistry Advising
Office (1500 Chemistry), and one copy for the student. Interim
reports need not be lengthy, but the final report for Chemistry
398 is expected to be more detailed and longer than the reports
in 218.

For a student to receive biochemistry credit for Chem 398, the student must work on a research project supervised by a member
of the biochemistry concentration research faculty and the project
must be approved by a biochemistry advisor. Final evaluation of the research effort and the report, as well as the grade for the
course, rests with the biochemistry research faculty member. Cost:1WL:3Check
Times, Location, and Availability

399. Undergraduate Research.
Junior standing, and permission of a chemistry concentration
advisor and the professor who will supervise the research. (1-4).
(Excl). (INDEPENDENT). May be repeated for a total of four credits
during junior or senior year.
Elected starting in the junior or senior year, this course is
a requirement for B.S. Chemistry students, who must elect it for
a total of four credits spread out over two or more terms. The
student is expected to put in at least three hours a week of actual
work for each credit elected. At the end of each term, a written
report evaluating the progress of the project is submitted; one
copy to the faculty member, one copy for the Chemistry Advising
Office, and one copy for the student. Interim reports need not
be lengthy, but the final report for Chemistry 399 is expected
to be more detailed and longer than the reports in 219.

For a student to receive Chemistry credit for Chemistry 399, the student must work on a research project supervised by a faculty
member of the Chemistry Department, either alone, or in collaboration
with a colleague within the department, from another department, or from another school. This collaboration must be an ongoing
one, and the student must receive direct supervision by all of the faculty who have agreed to sponsor the project. Final evaluation
of the research effort and the report, as well as the grade for the course, rests with the faculty member from the Chemistry Department.
Cost:1WL:3Check
Times, Location, and Availability

402. Intermediate Inorganic
Chemistry. Chem. 302, and 461/462 (or 469). (3).
(Excl). (BS).
Chemistry 402 is a second-term course in inorganic chemistry at the undergraduate level. It has as a prerequisite Chem 302. The
goals of the course are two-fold. On the one hand, it will build
upon the concepts presented in the earlier course. Topics included
here will emphasize the interrelations of ideas presented earlier
in the curriculum. For example, discussion can include the relation
between oxidation and reduction and acidity, periodic trends in
acids and bases, the relation of hard and soft ideas to molecular
orbital theory, periodic trends in standard reduction potentials, the relation of molecular structure to conductivity and magnetism.
The key topics to be covered in this portion of the course include
acid-base chemistry, theories of bonding, periodic properties
and d- metal complexes. The course goes on to cover additional
topics selected from issues in catalysis, bioinorganic chemistry, structure-property relations, solid state chemistry, organometallic
chemistry, kinetics of organometallic reactions, f- block compounds, electron deficient clusters, and quantum models of structure and bonding. The course has three lectures per week. There will be
1-3 exams and a final. Weekly homework problems will be assigned.
(Rasmussen)Check
Times, Location, and Availability

447. Physical Methods
of Analysis. Chem. 260 and 241/242 (or 340). (3).
(Excl). (BS).
This course introduces the student to the principles and techniques
of modern analytical chemistry. Atomic and molecular spectroscopy, mass spectrometry, and chromatographic separation techniques are
stressed. Some discussion of contemporary electrochemistry is
included. The principles of data collection and the processing
and representation of analytical signals are introduced. The course
format is lectures three times per week. A textbook is required.
Readings from the review literature of analytical chemistry compensate
for the inevitable shortcomings of any text. Cost:3WL:2 (Morris)Check
Times, Location, and Availability

451/Biol. Chem. 451.
Introduction to Biochemistry I. Chem. 215, Biol.
152 or 195, and Math. 115. No credit granted to those who have
completed or are enrolled in Biol. 311 or Biol. Chem. 415. (4).
(Excl). (BS).
This course is the first in a two-term sequence designed for students
who are concentrators in biochemistry. Emphasis is on developing the capacity of the students to think about complex biological
processes in terms of the underlying chemistry. An introductory
section on proteins is followed by sections on enzymes and coenzymes.
The discussion of biochemical energetics includes sections on
glycolysis, the tricarboxylic acid cycle, electron transport, photosynthesis, and carbohydrate metabolism. The course has three
lectures and one discussion per week. There are three hour exams
and a final exam. (Yocum,Coward)Check
Times, Location, and Availability

461. Physical Chemistry
I. Chem. 260 (or 340), Phys. 240, and Math. 215.
No credit granted to those who have completed Chem. 397 or 469.
(3). (Excl). (BS).
Section 100. This is the second of the three-term physical
chemistry sequence Chemistry 260/461/463. Chemistry 461 builds
on the introduction to quantum mechanics that was given in Chemistry
260. Students will use the Schrödinger Equation in 1, 2, and 3-dimensions to solve exactly a series of important chemical
problems including the harmonic oscillator, the rigid rotor, and the hydrogen atom. Group theory is introduced as an aid for understanding
spectroscopic selection rules. Advanced spectroscopy, including
transition probabilities, normal vibrational modes, and photoelectron
spectroscopies are introduced and then used to deduce molecular
structure. The valence-bond and molecular orbital theories of
chemical bonding are discussed, and methods for performing quantum
chemical calculations, including variational and perturbation
methods, are introduced. The quantum mechanics of spin and angular
momentum are discussed and used to interpret magnetic resonance
spectra. (Griffin)

Section 200. (Honors). This section is designed to
introduce students to a more thorough, research-oriented view
of Physical Chemistry. (Lubman)

NOTE: Students are strongly encouraged to elect the Computational
Chemistry Laboratory (Chemistry 462, 1 credit) in the same term that Chemistry 461 is taken.Check
Times, Location, and Availability

462. Computational Chemistry
Laboratory. Math. 215, and prior or concurrent enrollment
in Chem. 461. (1). (Excl). (BS).
This course introduces modern computational tools for symbolic
mathematics and for graphical display (Mathematica and Maple). Examples are given of the use of these tools
for solving problems in quantum mechanics and quantum chemistry, including exploration of the functional forms of wave functions, solutions of simple differential equations, and diagonalization
of Hamiltonians. Molecular modeling software (HyperChem
and CAChe) is introduced and used to perform both ab
initio and semi-empirical quantum chemical calculations.
The examples used are taken largely from the topics discussed
in Chemistry 461. (Griffin)

NOTE: Students are strongly encouraged to elect the second
term of Physical Chemistry (Chemistry 461, 3 credits) in the same
term that Chemistry 462 is taken.Check
Times, Location, and Availability

463. Physical Chemistry
II. Chem. 461/462. No credit granted to those who
have completed Chem. 396 or 468. (3). (Excl). (BS).
This is the third of the three-term physical chemistry sequence
Chemistry 260/461/463 and builds on material presented in both
previous courses. The rigorous mathematical theory of classical thermodynamics will be developed, including applications to entropy, heat engines, solution properties, and phase and chemical equilibria.
Modern statistical thermodynamics will be introduced. Modern theories
of fundamental reaction rates will be used built on the phenomenological
kinetics introduced in Chemistry 260. Methods for determining
and understanding solid state structures will be discussed, building
on group theory introduced in Chemistry 461. (Kopelman)Check
Times, Location, and Availability

467/AOSS 467/Geol. 465.
Biogeochemical Cycles. Math. 116, Chem. 210, and Phys. 240. (3). (Excl). (BS).
Biogeochemical cycles describe how carbon, nitrogen, sulfur, and other elements cycle through not only the atmosphere, the oceans, and the landmasses of the earth. This course is useful to students
in many fields including engineering, atmospheric science, chemistry, biology, geology, natural resources, and public health. The biogeochemical
cycles of water, carbon, nitrogen, and sulfur; the atmosphere
and oceans as reservoirs and reaction media; the fate of natural
and human-made sources of carbon, nitrogen, and sulfur compounds; the interactions among major biogeochemical cycles and resultant
global change: greenhouse gases, acid rain, and ozone depletion.
(Carroll)Check
Times, Location, and Availability

480. Physical and Instrumental
Chemistry. Chem. 447 and 461/462; and concurrent
enrollment in Chem. 463. (3). (Excl). (BS). Laboratory fee ($50)
required.
This course explores methods for the measurement of the physical
and spectroscopic properties of substances and the application
of these methods in instrumental analysis. The course is focused
on essential laboratory principles and operations as they relate
to the physicochemical properties of organic, inorganic, and macromolecular
chemical species. Experiments study the areas of equilibria, chemical
structure, chemical change, and computer simulation and calculation.
Emphasis is placed on the effective design of experiments together
with synergistic coupling of modern instrumentation and computers.
The course includes literature searches for physical data. Laboratory
reports constitute an important component of the course. Ten to
twelve hours a week in the laboratory. Grading is based on laboratory
performance, laboratory records, and reports. WL:2
(Beck)Check
Times, Location, and Availability

485. Projects Laboratory.
Chem. 480. (2). (Excl). (BS). Laboratory fee ($50)
required.
A project-oriented laboratory in which students work on one or
two projects in depth during the term. The projects are suggested
by the faculty of the department and require library as well as
laboratory work. The projects may be in any area of analytical, inorganic, organic, physical, or polymer chemistry. Students interested
in projects in inorganic or organic chemistry should elect Section
100, 200, or 300. Students interested in analytical or physical
chemistry should elect Section 400 or 500. Eight hours a week
in the laboratory. Grading is based on laboratory performance
and a written report for each project undertaken. Cost:1WL:2 (Coucouvanis,
Staff)Check
Times, Location, and Availability

498. Undergraduate Honors
Thesis in Biochemistry. Chem. 398 and permission
of instructor. To be elected in the term in which an Honors student
presents a thesis on undergraduate research. (1). (Excl). (INDEPENDENT).
To be elected in the term in which an Honors biochemistry student
presents a thesis on undergraduate research. Cost:1WL:3 (Yocum)Check
Times, Location, and Availability

499. Undergraduate Thesis.
Chem. 399 and permission of instructor. To be elected
in the term in which an Honors student presents a thesis on undergraduate
research. (1). (Excl). (INDEPENDENT).
To be elected in the term in which an Honors student presents
a thesis on undergraduate research. Cost:1WL:3Check
Times, Location, and Availability

520(Biophysics 610)/Biophysics
520. Biophysical Chemistry I. Chem. 463, Biol. Chem.
415, or Chem 420; permission of course director. (3). (Excl).
(BS).
This course is the first or a two-term Biophysical Chemistry series
520/521, but it can be taken as stand-alone course as well. The
course offers an overview of protein, nucleic acid, lip and carbohydrate
structures. Intra- and inter-molecular forces, helix-coil transitions
and protein folding will be treated in a thermodynamical context.
Thermodynamics of solutions, configurational statistics, ligand interactions, multi-site interactions and cooperativity are treated
in depth. Kinetics of protein-ligand binding, including electron
transfer and ligand diffusion are discussed. Chemistry 520 will
introduce and explain the physico-chemical properties of biological
macromolecules and their complexes, mostly in solution. Currently, biophysical, biochemical and pharmaco-chemical research literature
is full with papers interpreting the properties of biological
macromolecules on the the basis of their three-dimensional structure.
This course will expand on that concept by offering a rigorous
background in energetics, folding, interactions, and dynamics.
As such the course is important to any student who has to deal
with the concepts of biomolecular function and structure such
as biochemists, biophysicists, mathematical biologists, and molecular
pharmacologists. This course will also serve as a basis for the
graduate student who will be specializing in any of these topics
for thesis research. Molecular dynamics will be introduced. Instructional
material: Cantor and Shimmel, Biophysical Chemistry, Part
I and III and Creighton, Proteins, Structures and Molecular
Properties. Evaluation: homework (50%), midterm exam (20%) and final exam (30%). (Zuiderweg)Check
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