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SUMMARY:Reflections on the Complex Molecular and Clinical Nature of Li-Fra
umeni Syndrome - Prof David Malkin (University of Toronto)
DTSTART;VALUE=DATE-TIME:20170525T100000Z
DTEND;VALUE=DATE-TIME:20170525T110000Z
UID:https://talks.ox.ac.uk/talks/id/1909e37d-b0b8-4939-9a55-9a05ef066c27/
DESCRIPTION:The causal association of germline TP53 mutations with develop
ment of cancer in individuals with the Li-Fraumeni Syndrome (LFS) cancer p
redisposition phenotype was initially described in 1990. Since then\, tech
nical advances in genetic and genomic sequencing\, enhanced understanding
of the biology of p53\, creation and study of mouse models of p53 deficien
cy and mutant p53\, and extensive annotation of the evolving clinical phen
otype has improved our knowledge of this relatively rare syndrome. Several
challenges remain to be overcome\; these include 1) the molecular landsca
pe of cancers associated with germline TP53 mutations is poorly understood
\; 2) effective means of tumor prevention and treatment are lacking\; and
3) prediction of tumor type or age of onset are difficult. This lecture wi
ll examine the progress made to date in understanding the molecular and cl
inical aspects of the p53-LFS relationship and will explore early clues th
at will help address the remaining challenges.\nSpeakers:\nProf David Malk
in (University of Toronto)
LOCATION:NDM Building (TDI\, Basement Seminar Room)\, Headington OX3 7FZ
URL:https://talks.ox.ac.uk/talks/id/1909e37d-b0b8-4939-9a55-9a05ef066c27/
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DESCRIPTION:Talk:Reflections on the Complex Molecular and Clinical Nature
of Li-Fraumeni Syndrome - Prof David Malkin (University of Toronto)
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