The best Franchise by far would be Archer. The 2.5D design of the show makes it comparatively easy to animate and design in game form, the show is largely driven by character interaction, and the player protagonist is unique in that the emphasis is on being a total dick to your colleagues.

There are other cool innovations you can work into a game adaptation as well - during the quick time events, instead of having instant death as a punishment for failing QTEs, you could have it so that Archer instead sustains a painful injury for each failed QTE prompt, that lasts throughout the episode. Thus letting Archer get the crap beaten out of him becomes not only a valid play decision, but also one that matches the style of the show. Another innovation would be conversations, in that the emphasis would be on smart arse comebacks or passive aggressivism - like dueling in Monkey Island - rather than simply convincing your interlocutors.

The star trek one i would pay real money for, I can't see any other game type that would work with star trek, even better if you got a crap tun of money and could do tng with the real actors voices while they are still all alive.

Hey, mine made the list. Still think they should have gone with my Dark Souls suggestion, but whatever works.

In light of Tales from the Borderlands, i feel like their games are better suited to comedy anyway, or at least more open to parody. The mock gunfight in episode 4 of Tales from the Borderlands is the best comedy shootout since Hot Fuzz.

Kingjackl:Hey, mine made the list. Still think they should have gone with my Dark Souls suggestion, but whatever works.

In light of Tales from the Borderlands, i feel like their games are better suited to comedy anyway, or at least more open to parody. The mock gunfight in episode 4 of Tales from the Borderlands is the best comedy shootout since Hot Fuzz.

I really liked the idea of comedic Dark Souls, but I know too many fans of the series who might try to hang me up by my entrails for even suggesting it.

Deus Ex:HR: Might work. Probably be better to focus one something a little less world devastating than most of DE's plots get. Something focusing on the sidestories you mentioned would probably be best.

Ocarina of Time: Don't think so. It basically sounds like The Walking Dead in Hyrule. It'd basically amount to "Survive until the great hero comes to save us", and I can't really say that sounds too much what people tend to want from Zelda games.

Space Quest: Can't deny it, I'm rather sold on this one. Though I might just be a sucker for good comedy.

Team Fortress 2: Yes. Just yes. More time with The Crew actually just interacting with one another and some time working with the game's rather extensive story? Shut up and take my money!

Ratchet and Clank: No. Just no. The biggest selling point with this series has always been running around and blowing the crap out of everything in sight with a ridiculous arsenal. An adventure game pretty much neuters this series' main selling point. (Plus, we've already got Ratchet's origin story for the most part.) That said, a game focused on the in-universe Secret Agent Clank show might actually work out. Clank's gameplay would lend itself pretty well to the Adventure genre.

Star Trek: No arguments here. Just one question. Original, Next Generation, or it's own thing?

Warcraft: Kind eh, but Lord of Clans keeps me from rejecting it outright. There's a LOT of potential if nothing else.

Fallout: Fuck. Yes. All of my fucks, and all of my yeses. Just take whatever money I have left from the Team Fortress idea while I get some loans from the bank so you can have more. This needs to be a thing.