The other changes are in the tight five with Jack McGrath starting at loose-head and Cian Healy dropping to the bench. Devin Toner returns to the second-row in the plack of James Ryan, who doesn't feature in the match day squad.

Best will draw level with Paul O'Connell as Ireland's third-most capped player of all time, on 108 Test appearances.

Peter O'Mahony joins Leavy and Conan to make up the back-row.

Schmidt has gone with the same back-line that started in Paris last weekend meaning Conor Murray and Johnny Sexton continue as half-backs.

Bundee Aki and Robbie Henshaw continue their partnership in the centre with Jacob Stockdale, Kieth Earls and Rob Kearney making up the back three.

Quinn Roux has been called up to the bench to cover second-row joining the uncapped Larmour. The rest of the replacements are made up of Sean Cronin, Cian Healy, Andrew Porter, CJ Stander, Kieran Marmion and Joey Carbery.

Jordan Larmour

Ireland boss Schmidt insisted potential debutant Larmour will not need his hand held if he joins the fray.

"I expect Jordan to provide what he's been providing in the provincial matches so far, that raw acceleration and the ability to beat players," said Schmidt, of Larmour.

"And without the ball he wants to make a big contribution too. It's a good situation that he could potentially slot in around experienced players, but at the same time, you don't place a player and expect them to be looked after.

"He has an expectation that he'll look after himself and look after what he needs to do and bring those exciting elements I talked about to the game."

Leinster have brought the curtain down on the Heineken Champions Cup pool stages with the easiest of victories away to Wasps on Sunday afternoon that confirms for them an all-Irish home quarter-final against Ulster at the end of March.