Preparation and Storage

This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

Alternative names

RING finger protein 88

RNF88

TRIM5

TRIM5_HUMAN

Tripartite motif containing 5

Tripartite motif protein TRIM5

Tripartite motif-containing protein 5

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FunctionIsoform Alpha is a retrovirus restriction factor, which mediates species-specific, early block to retrovirus infection. Targets retroviral capsid soon after entry into the cell, and prevents reverse transcription of the virus RNA genome. Isoform Alpha trimers may make multiple contacts with the hexameric lattice of CA proteins which constitute the surface of retrovirion core, and somehow inactivate the virus. Restricts efficiently infection by N-MLV, but not HIV-1. May have E3 ubiquitin-protein ligase activity.