In my work as a technical support engineer I have come across many different problems caused by faulty Interrupt Remapping, with varying symptoms.
Depending on which device is affected, a system may lose network connectivity, access to storage devices, or experience a panic.
This can result in unmanageable hosts, unresponsive or failed virtual machines, system hangs or unexpected reboots.

On linux hosts, Interrupt Remapping can be disabled by booting the system with intremap=off.
On VMware ESX/ESXi hosts, the same result can be achieved by setting the iovDisableIR kernel parameter to TRUE.

Over the course of the past two years, a few hardware and software vendors I have worked with have published articles describing this issue.
Some of these are relatively new, others have been recently updated and improved.
I have referenced them below, in alphabetical order.

Additional note on linux:
Earlier this year, a patch was introduced in the Linux kernel to warn system administrator that their system is affected by this problem.
To my knowledge, this patch is included in recent kernel updates for the OpenSuSE, SLES, Fedora and RHEL linux distributions.