The day marks the high point of the Italian summer holiday season when most cities and business are closed and Italians head to the beaches or the mountains, which means traffic was heavier than usual on the Genoa highway.

A motorway bridge collapsed on Tuesday over the northern Italian port city of Genoa, killing dozens of people according to the local ambulance service, in what the transport minister said was likely to be "an vast tragedy".

ANSA says five people have been hospitalised in life-threatening conditions. The Interior Ministry press office could not immediately confirm the fatalities.

"Firefighters are working together and teams of rescuers and police sniffer dogs have been mobilized", emergency services said on Twitter.

By early afternoon, about 200 firefighters were on the scene, and government officials were en route. Restructuring was carried out in 2016. Local police and figure brigade officials said that no injuries or deaths had been reported so far, according to news agency Reuters.

Authorities had no information regarding the number of potential victims.

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