Deletions of the 22q11.2 have been associated with a wide range of developmental defects (notably DiGeorge syndrome velocardiofacial syndrome conotruncal anomaly face syndrome and isolated conotruncal cardiac defects) classified under the acronym CATCH 22. The DGCR2 gene encodes a novel putative adhesion receptor protein which could play a role in neural crest cells migration a process which has been proposed to be altered in DiGeorge syndrome. Alternative splicing results in multiple transcript variants.[provided by RefSeq May 2010]