Abstract

Extracted from text ... SA Pharmaceutical Journal - May 2006 36
CLINICAL
Reprinted with permission from CME April 2005 Vol. 23 No. 4
Oestrogens and continence
Oestrogen-sensitive tissues of the
bladder, urethra and pelvic floor all
play an important role in the continence
mechanism. Oestrogens increase
urethral closure pressure and improve
abdominal pressure transmission to the
proximal urethra. The sensory
threshold of the bladder to irritative
symptoms may be raised, and over 60
years ago physicians reported the
successful use of oestrogens to treat
urinary incontinence. Further studies
showed impressive subjective improvements
of up to 70%, but initial trials took
place before the widespread ..