Matrix Metalloproteinases and TIMPs

J. Frederick Woessner and Hideaki Nagase

Matrix Metalloproteinases and TIMPs

J. Frederick Woessner and Hideaki Nagase

Description

The matrix metalloproteinases (MMPs) are a large family of enzymes that breakdown different components of the extracellular matrix. Their catalytic activity is dependent a metal ion, usually zinc. This issue of the Protein Profiles covers the sequence information, three-dimensional structures, activation, protein substrates, specificity requirements, inhibition, and biological roles of all the currently identified MMPs. The action of these enzymes must be carefully regulated. One way the cell does this, is by releasing inhibitory molecules known as tissue inhibitors of metalloproteinases (TIMPs). This volume contains information on the sequences, three-dimensional structures, and biological roles of the 4 known classes of TIMP. Matrix metalloproteinases will
therefore be an invaluable source of data for all researchers interested in MMPs and TIMPs.

Matrix Metalloproteinases and TIMPs

J. Frederick Woessner and Hideaki Nagase

Table of Contents

Abbreviations; Introduction; MMP sequences; TIMP sequences; Three dimensional structures of the MMPs and TIMPs; Activation of the zymogen forms of MMPs; Protein substrates of the MMPs; Specificity requirements of the MMPs; Inhibition of the MMPs; Biological roles of the MMPs; Biological roles of the TIMPs; Bibliography; Protein sequence alignments