BALTIMORE – The Chicago White Sox were hoping for one last magic act from closer Addison Reed. It just didn't work out.

The end of this show left them shaking their heads once again.

Reed yielded Matt Wieters' game-ending, two-run single in the 10th inning, sending Chicago to a 4-3 loss at the Baltimore Orioles on Saturday.

It was the ninth consecutive loss for the White Sox, who grabbed a 3-2 lead on Conor Gillaspie's pinch-hit homer against Tommy Hunter (4-3) in the top half of the inning.

Baltimore was 1 for 17 with runners in scoring position before Wieters' hit.

"There was a lot of Houdini stuff going on in there," White Sox manager Robin Ventura said of his pitchers. "They'd get in trouble and work their way out of it. With the way it was going today, you almost figured Reed was going to do the same thing, but it just didn't happen."

Pinch-hitter Henry Urrutia started the winning rally with a one-out infield single against Reed (5-3). Pinch-runner Chris Dickerson then went all the way to third on Nick Markakis' base hit.

Reed bounced back with a strikeout of Nate McLouth, but Markakis stole second and both runners scored when Wieters lined a single into right field.

"I'm sure you've heard it before, I feel like we see something new every game," Reed said. "Things just aren't going our way and today it was a bad pitch by me. It happens, it's baseball. Things can happen like that and all we can do is come back tomorrow and do everything we can to get the win."

Danny Valencia had three hits and Brian Roberts homered for the Orioles, who have won three straight. They began the day two games behind Tampa Bay for the final AL wild-card slot.

"We had some chances early in the game, but they made some pitches to get out of it," Wieters said. "You always have a shot until the last out. ... We knew we were still in it all the way until the end. It was a big win for us."

The Orioles improved to 7-5 in extra-inning games while the White Sox fell to 9-14.

Dayan Viciedo also homered for last-place Chicago, and Paul Konerko had two hits.

After scoring in the third inning of Thursday's series opener, Chicago went 18 innings without a run until Konerko singled in Alexei Ramirez in the fourth.

Viciedo connected in the fifth, giving the White Sox a 2-1 lead, but Roberts went deep in the bottom half, tying the game with Baltimore's major league-leading 192nd homer.

Each team then had its chances to move in front, but couldn't come up with a clutch hit.

Baltimore left Adam Jones at third with two outs in the seventh inning. The Orioles had two runners on in the eighth, but pinch-hitter Wieters struck out and Roberts grounded out.

Hector Santiago threw five solid innings for the White Sox, allowing two runs and seven hits. The left-hander is 1-3 with a 3.80 ERA in his last 13 starts.

"I guess it seems like that kind of year, just always goes the other team's way for some reason," Santiago said. "It's a tough one."

Baltimore left-hander Wei-Yin Chen gave up two runs and six hits in six innings. He struck out eight and walked none.

The Orioles grabbed the lead when Chris Davis doubled into the gap in left-center in the first, driving in Manny Machado from first. The hit lifted Davis' total to 124 RBIs, second-most in the majors behind Detroit's Miguel Cabrera.

NOTES: White Sox pitching coach Don Cooper missed the game after a reoccurrence of diverticulitis led to him being hospitalized. Cooper also missed time in April due to the ailment. ... Chicago lost three at Boston and three at Yankee Stadium before arriving in Baltimore. ...Orioles starter Bud Norris (10-10, 4.01 ERA) opposes fellow RHP Andre Rienzo (1-1, 5.03 ERA) in Sunday's series finale.