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Webinar: Kappa Opioid Antagonists for Migraine and Pain

On January 31, Frank Porreca gave a talk on kappa opioid antagonists for migraine and pain. After his talk, there was a panel discussion featuring:

Jose Moron-Concepcion, Washington University, St. Louis, US

Elyssa Margolis, University of California, San Francisco, US

Michael Oshinsky, NINDS/NIH, Bethesda, US

Greg Dussor, University of Texas at Dallas, US (moderator)

Watch the webinar below.

A PAIN article from Porreca and colleagues mentioned in this webinar is freely available for a limited time. The article can be accessed here.

Here is an abstract of Porreca's talk:

Many patients suffer from chronic pain in the absence of identifiable injury. Stress is known to play an important role in promoting such functional pain disorders but the precise mechanisms and circuits involved remain unclear. This presentation will explore the role of dynorphin/kappa opioid receptor (KOR) signaling in stress-related functional pain in a preclinical, injury-free model. The presentation will discuss data on the role of a KOR-mediated descending pathway from the amygdala that may promote stress-related pain. The possible development of kappa opioid receptor antagonists for therapeutic application in functional, and other, pain conditions will also be presented.

Want some background reading? See the recent papers under Related Content in the right column of this page. And join the conversation about the webinar on Twitter @PainResForum#PRFWebinar