The story concerns an unhinged US Air Force general who orders a first strike nuclear attack on the Soviet Union, and follows the President of the United States, his advisors, the Joint Chiefs of Staff and a Royal Air Force (RAF) officer as they try to recall the bombers to prevent a nuclear apocalypse, as well as the crew of one B-52 as they attempt to deliver their payload.

In 1989, the United States Library of Congress deemed the film "culturally significant" and selected it for preservation in the National Film Registry. It was listed as number three on AFI's 100 Years... 100 Laughs.