The Fenton Works Lab, located in the basement, contains the Fentons' ghost portal, which provides Danny and his friends with access to the Ghost Zone.

In "The Million Dollar Ghost," it's revealed that Fenton Works has a weapons vault (with no handle on the inside), which Maddie and Jazz get trapped in. In "Kindred Spirits" there is a pool that opens when the Specter Speeder comes through.

The entire building is fitted with hidden turrets and other ghost defenses that when activated, will pop out of the walls and ceiling and automatically attack anything using ectoplasmic energy. However, these defenses can be a double-edged sword, since it will target humans using ecto-weapons as well as ghosts.