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By the time firefighters got to the scene three minutes after the initial call, the fire had become so intense that the third floor collapsed.

A firefighter was also injured, officials said.

"With the collapse," Clark said, "it's going to make this a very labor intense-type situation at this time, in terms of trying to search for any additional victims that may be inside the home."

U.S. Rep. Elijah Cummings office identified the woman injured in the fire as one of his staff members.

In a statement, Cummings' office said:

“I am asking that our entire community pray for my staff member, Katie Malone, and her young family. Katie has worked as a Special Assistant in my Catonsville office for nearly 11 years where she dutifully serves my constituents in the areas of immigration, postal services, and the military, including Service Academy nominations. I am grateful to the Baltimore City Fire Department and all those who responded quickly to the devastating fire. My staff is a family and this unimaginable tragedy is shocking and heartbreaking to us all. I again ask for your prayers.”

An excavator arrived to pull debris from fire scene.

A GoFundMe page has been set up to help the family with expenses. You can donate here.