Provigan
msds (material safety sheet)

Provigan
Synthesis Reference

Provigan
Molecular Weight

Provigan
Melting Point

Provigan
H2O Solubility

Provigan
State

Solid

Provigan
LogP

4.946

Provigan
Dosage Forms

Tablet; Suppository; Opthalmic drops; Syrup

Provigan
Indication

For the treatment of allergic disorders, itching, nausea and vomiting.

Provigan
Pharmacology

Promethazine, a phenothiazine, is an H1-antagonist with anticholinergic, sedative, and antiemetic effects and some local anesthetic properties. Promethazine is used as an antiemetic or to prevent motion sickness.

Provigan
Absorption

On average, 88% of a promethazine dose is absorbed after oral administration; however, the absolute bioavailability is only 25% because of first-pass clearance.

Provigan
side effects and Toxicity

Symptoms of overdose include mild depression of the central nervous system and cardiovascular system to profound hypotension, respiratory depression, unconsciousness, and sudden death. Other reported reactions include hyperreflexia, hypertonia, ataxia, athetosis, and extensor-plantar reflexes (Babinski reflex). LD50=55mg/kg (I.V. in mice)