Conflict of interest statement

Competing interests: Andrew Kirkpatrick is the principal investigator of the COOL trial (https://clinicaltrials.gov/ct2/show/NCT03163095), with partial unrestricted funding from Acelity. He has also consulted for Innovative Trauma Care and SAM Medical Products. Jessica McKee is the Research Director of Innovative Trauma Care and has consulted for Aceso, SAM Medical Products and Acelity. Andrew Kirkpatrick and Jessica McKee also disclose a personal relationship.