President Barack Obama and Mexico’s President Enrique Pena Nieto shake hands Thursday after offering a joint news conference in Mexico City, Mexico. Seeking to put a new spin on a long-standing partnership, Obama is promoting jobs and trade — not drug wars or border security — as the driving force behind the U.S.-Mexico relationship.

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Acknowledging uncertainty ahead, President Barack Obama said Thursday the U.S. will cooperate with Mexico in fighting drug-trafficking and organized crime in any way Mexico’s government deems appropriate. Mexican President Enrique Pena Nieto emphasized that the security relationship must be expanded to focus on trade and commerce.