..These studies indicate that p66Shc is not a longevity protein. However, additional studies are needed to determine the extent to which Shc proteins may influence the onset and severity of specific age-related diseases...

Mealtime, temporal, and daily variability of the human urinary and plasma metabolomes in a tightly controlled environment

Kyoungmi KimDivision of Biostatistics, Department of Public Health Sciences, University of California, Davis, Davis, California, United States of AmericaPLoS ONE 9:e86223. 2014

..In light of these findings, future metabolomics studies should consider these sources of variability to allow for appropriate metabolomics testing and reliable clinical translation of metabolomics data. ..

..Further evaluation of the global metabolomics analysis, as well as confirmation of the specific potential biomarkers using a larger sample size, will lead to new avenues of kidney cancer diagnosis and therapy...

..The results demonstrate that both male and female CGG KI mice showed a greater number of foot slips as a function of increased CGG repeat length, independent of the age of the animal or general activity level...

..Further, a combination of IR and inflammation resulted in a higher degree of CAD in both Caucasians and African Americans. The results suggest that inflammation may potentiate the cardiovascular risk factor role of IR...

Identification of positional candidate genes for body weight and adiposity in subcongenic mice