HIV-associated nephropathy is rare in children. Proteinuria can be its first sign. In the black child, it often presents as focal and segmental glomerulosclerosis. White children are mostly affected with mesangial hyperplasia, rarely with IgA nephropathy. Its etiology is probably multifactorial: presence of the virus itself in the glomeruli, hemodynamic alterations and drug toxicity. There is no specific treatment at the moment.