Antiproliferative potencies of cannabinoids during a 3-d treatment of MDA-MB231 and MDA-MB436 breast cancer cells

Compound

MDA-MB231

MDA-MB436

Δ9-THC

1.2 (1.0–1.4)

2.5 (1.8–3.4)

CBN

1.2 (0.9–1.5)

2.6 (1.8–3.7)

WIN55,212-2

1.7 (1.5–2.2)

2.4 (1.6–3.4)

CP55,940

2.5 (1.5–4.1)

1.3 (0.7–1.6)

CBD

1.3 (1.0–1.9)

1.6 (1.1–2.2)

CBG

2.3 (2.1–2.5)

2.1 (1.5–3.0)

NOTE: Cells were treated with cannabinoid compounds for 3 d and the IC50 values for the antiproliferative effects of the compounds were calculated. Data are the means and corresponding 95% confidence limits of at least three experiments. IC50 values are reported in μmol/L.