Primary culture of
airway epithelial cells is a valuable model for the study of lung disease
and has been crucial for understanding the biology and therapy of cystic fibrosis,
a major genetic lung disease of children.
Cells in these cultures are
differentiated into ciliated and secretory types, providing a vital model that can
also be used for research in asthma, respiratory virus infection, and other childhood
lung diseases.

The goal of the core is to provide primary culture airway epithelial cell preparations
from human and mouse for use by investigators studying basic epithelial cell lung
biology and therapeutic strategies for lung diseases in children.