Launching in Release mode may also start Apple’s simulator on the networked Mac.

Closing the remoted iOS Simulator on Windows will not immediately stop debugging in Visual Studio. Stop debugging manually from the menu or the red button.

Opening too many different simulators simultaneously will produce unexpected results.

Exception of type Foundation.NSErrorException may be thrown while launching Simulators. Workaround is to kill csproxy (server process) on the Mac host and re-deploy to the simulator.

Microsoft also announced that Xamarin would be free to all Visual Studio users at the same event. In fact, the recent release of Visual Studio 2015 Update 3 introduces Xamarin 4.1, which includes support for building tvOS apps.