Description

Chemical modifications (e.g., methylation and acetylation) to the histone proteins
present in chromatin influence gene expression by changing how
accessible the chromatin is to transcription. A specific modification of
a specific histone protein is called a histone mark.
This track shows the levels of enrichment of the H3K27Ac histone mark across the genome as
determined by a ChIP-seq assay. The H3K27Ac histone mark is the acetylation of lysine 27 of the H3
histone protein, and it is thought to enhance transcription possibly by blocking the
spread of the repressive histone mark H3K27Me3. Additional histone marks and other chromatin
associated ChIP-seq data is available at the
Broad Histone page.

Display Conventions and Configuration

By default, this track uses a transparent overlay method of displaying data from a number of cell
lines in the same vertical space. Each of the cell lines in this track
is associated with a particular color, and these colors are relatively light and saturated so
as to work best with the transparent overlay. The color of these tracks
match their versions from their lifted source on the hg19 assembly. The colors are consistent with the
other hg19 lifted tracks located in the ENCODE Regulation
supertrack, with the exception being the DNase tracks, as they were not lifted from hg19 and are
colored to reflect similarity of cell types.

Credits

This track shows data from the Bernstein Lab at the Broad Institute, as part of
the ENCODE Consortium.

Data Release Policy

Primary ENCODE data produced during the 2007-2012 production phase were subject to a restriction
period. However, the data here are past those restrictions and are freely available.
The full data release policy for ENCODE is available
here.