Before treatment:
Avril’s mother had regular antenatal examinations and all the tests showed nothing abnormal. She was delivered by caesarean section at full term. Her head was smaller than other babies when she was born. At the age of 5 months, she began to have epileptic attacks. When she had the epileptic attacks, her whole body would be stiff and spastic, she had multiple seizures, each time lasting between 10and 60 seconds. After the seizures she would sleep more. The MRI showed it was nanocephaly, the doctor prescribed Valproic Acid and Oxcarbazepine to control the epileptic seizures, but her condition did not improve. When she grew older, her motor function and cognitive function deteriorated, so she had some physical rehabilitation training.

At present, Avril’s vision is bad, she is not able to speak, turn over, sit up or stand up. She is depressed. She is on a diet of soft food. She sleeps a lot. She has difficulty urinating. She is incontinent and defecates 3-4 times per day.

Admission PE: Temperature: 35.5℃, Bp: 112/62mmHg; Hr: 93/min, Br: 18/min. Height: 118 cm, weight: 17kgs. There were no yellow stains or petechia on the skin or mucosa. The respiration in both lungs was clear; there were no dry or moist rales. The heart sounds were strong, the rhythms of the heartbeat were regular and there was no obvious pathological murmur. The abdomen was soft and flat, with no masses touched. The liver and spleen were normal.

Nervous System Examination:
Avril Buson was alert, she was speechless, she was only able to say ”ah”. She was not able to cooperate with the memory, calculation ability or orientation examinations. She had epileptic attacks 2-4 times each day, lasting for 10-60 seconds each time. Most of the attacks were during the daytime and sometimes during the nighttime. Both pupils were equal in size and round, the diameter was about 3.0mms. Both eyes had sensitive responses to light stimuli and she had ocular bobbing. She was not able to cooperate with the vision or vision field examinations. The bilateral nasolabial sulcus was equal in depth. She didn’t cooperate when the doctor asked her to open her mouth or extend her tongue out. There was hypertrophy in the gums. She was not able to move her limbs well. She was not able to cooperate with the muscle power examinations. She was able to grasp objects with both hands. She was not able to turn her body over or sit up. She was not able to stand or walk by herself. The abdominal reflex was a little weak. The tendon reflex of both upper limbs was abnormal. The tendon reflex of both lower limbs was diminished. The sucking reflex was negative. The palm jaw reflex, Hoffmann’s sign and Rossolimo’s sign were negative. The Babinski’s sign was probable positive. She was not able to cooperate with the sensation and coordinated movements during examinations. The meningeal irritation sign was negative. EEG (outer hospital): wide sharp waves. Head MRI (outer hospital): agenesis of corpus callus, abnormal posterior cranial fossa.

Treatment:
Avril Buson received a complete examination and she was diagnosed with chronic encephalopathy(secondary epilepsy). She received four neural stem cell injections and four mesenchymal stem cell injections to repair her damaged nerves, activate the new cells in her body, nourish the neurons so that her brain nerves will grow,, improve the blood circulation, regulate the immune system functioning and control the epilepsy. This was accompanied with rehabilitation training of the movements, language and cognitive function.

Post-treatment:
After 21 days of treatment, Avril gained 1 kg of weight, her mood improved and her appetite increased. The ocular bobbing improved. The number of epileptic seizures decreased and the duration of each attack was shorter. She was able to control her head and waist better. She was able to turn body over. Her hands were able to hold objects better and more powerfully. She was able to raise her legs and kick.