TSC1 polyclonal antibody

Product Specification

Synthetic peptide corresponding to the sequence near the middle of human TSC1.

UniProt ID:

Q92574

Species reactivity:

Human, Mouse, Rat

Applications:

ICC, WB

Recommended Dilutions/Conditions:

Immunocytochemistry (2µg/ml)Western Blot (1µg/ml)Suggested dilutions/conditions may not be available for all applications.Optimal conditions must be determined individually for each application.

Purity Detail:

Peptide affinity purified.

Formulation:

Liquid. In PBS containing 0.02% sodium azide.

Shipping:

Blue Ice Not Frozen

Long Term Storage:

+4°C

Scientific Background:

Tuberous sclerosis complex (TSC) is an autosomal dominant tumor syndrome caused by mutations in either of the TSC1 (Hamartin) or TSC2 (Tuberin) tumor suppressor genes. The products of these genes form a protein complex that indirectly decreases mTOR signaling via stimulation of Rheb GTPase activity.

Immunocytochemistry analysis of TSC1 in EL4 cells with TSC1 antibody at 2µg/ml.

Western blot analysis of TSC1 in EL4 cell lysate with TSC1 antibody at 1µg/ml in the (A) absence and (B) presence of blocking peptide.