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Joyce Clemons, 53, who lives near the accident scene, heard a "horrendous crash" and rushed outside.

The woods on the side of the road appeared to be on fire, she said. She did not see the Pontiac. It was too badly burned to make out that it was a car, she said.

Clemons saw bodies in the road, including the driver of the bus. She asked the driver how many kids were onboard and then ran over to check them out.

"There was a little girl hanging out the back window," she said. "I told her to just be still. Help was on the way. She was in a daze."

Eddie Jackson, 41, a truck driver from Lake City, said he came upon the accident right after it happened. He said he saw injured children in the road, including one girl with bone exposed on a knee.

Dozens of FHP troopers, sheriff's deputies and emergency workers descended on the scene. The road, a main artery through sparsely population Union County, remained closed Wednesday night.

The FHP identified the dead as two sisters, Ashley Keen, 14, and Miranda Finn, 10; and five other children who are believed to be related, Cynthia Nicole Mann, 15, Elizabeth Mann, 15, Heaven Mann, 13, Johnny Mann, 13, and Anthony Lamb, 20 months.

The FHP said the mother of the Mann children is Barbara Mann, and that all seven children live in the same house.

A preliminary investigation did not find skid marks or any indication that the truck driver tried to stop before hitting the Pontiac, Burroughs said.

"We can't speculate on anything at this point," Burroughs said. Troopers will look into whether speed or any truck malfunction contributed to the crash.

Ralph Ives, a Shands at the University of Florida hospital spokesman, said eight patients were transported to the hospitals after the accident.

Seven of the eight were children, ages 5 to 16. Five were at Shands on Wednesday evening. Two of those were in critical condition and three were in serious condition, he said.

Officials said the bus driver, Lillie Mae Perry, was thrown from the vehicle and was taken to a hospital with non-life-threatening injuries.

Burroughs said the truck was owned by the Crete Carrier Corp. Troopers were trying to contact the business.

The National Transportation Safety Board said it was sending a team of investigators.

About 10 people a year die as a result of crashes while riding on school buses, making school buses one of the safest forms of transportation, according to a U.S. Department of Transportation's National Highway Traffic Safety Administration study in 2002.

Times new researchers Caryn Baird and Angie Drobnic Holan contributed to this report, which used information from the Associated Press and the Gainesville Sun.