In addition, the panel leveled five counts of reckless driving causing bodily injury to Harris, Marini and three other people injured in the July 11 crash.

About 20 cars were hit and 27 people injured when the 18-wheel cement truck driven by Little lost its brakes and plowed into stop-and-go traffic, District Attorney Bob Lee said. The grand jury considered only the most seriously injured victims in Wednesday's indictment, Lee said.

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"Clearly, this could have been prevented," Lee said of the crash. "It was more than a tragedy -- it was a criminal act."

The indictment charged Little with gross negligence, reckless conduct and driving with "willful or wanton disregard" for the safety of others on the road. However, the accident report compiled by the California Highway Patrol was not made public, and Lee would not discuss the evidence that led to the charges.

A $105,000 arrest warrant was issued for Little, who authorities say is expected to turn himself in. Little has been cooperating with authorities and voluntarily submitted to drug tests after the crash. No evidence of drug or alcohol use was found.