Methemoglobinemia is associated with a dark brown or chocolate appearance of the blood, particularly venous blood. Cherry red spots are associated with carboxyhemoglobinemia. High fever is associated with sepsis, or much less commonly, neuroleptic malignant syndrome. Pale nailbeds are associated with decreased perfusion or any shock-like state. Rotary nystagmus is associated with phencyclidine intoxication.

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