[Urinary Bladder Neoplasms]Homozygotes for the C allele are thought to be slowest acetylator phenotype (altered rates of metabolism of arylamines) of the NAT2 phenotypes, though results from one study indicated requirement for an additional SNP C481T;this is the most strongly associated of the NAT2 polymorphisms with risk of bladder cancer and with adverse drug reactions.www.ncbi.nlm.nih.gov/pubmed/10667461; PubMed ID:10971207; PubMed ID:12351146; PubM