W2 domain (IPR003307)

Domain relationships

Description

Translation initiation is a sophisticated, well regulated and highly
coordinated cellular process in eukaryotes, in which at least 11 eukayrotic
initiation factors (eIFs) are included. The W2 domain (two invariant
tryptophans) is a region of ~165 amino acids which is found in the C terminus
of the following eIFs [PMID: 8520487, PMID: 10958635, PMID: 14681227, PMID: 16616930, PMID: 16781736]:

The W2 domain has a globular fold and is exclusively composed out of alpha-
helices [PMID: 14681227, PMID: 16616930, PMID: 16781736]. The structure can be divided into a structural
C-terminal core onto which the two N-terminal helices are attached. The core
contains two aromatic/acidic residue-rich regions (AA boxes), which are
important for mediating protein-protein interactions.