South African Guidelines for the Prevention of Malaria (2017)

Travellers to, and residents in, malaria endemic areas are at risk of acquiring malaria. Stringent non-drug measures should be taken to avoid mosquito bites throughout the year, even in low malaria transmission areas.

In addition, effective chemoprophylaxis should be taken whenever and wherever the risks of acquiring malaria exceed the probability of experiencing a serious adverse reaction to the chemoprophylaxis. The risk of acquiring malaria is determined by the malaria transmission intensity in the area, season of visit, length of stay, type of accommodation, and likely activities between dusk and dawn.