Pretty sure that nothing in a Zelda game is ever miss-able. Except maybe meaningless dialogue from NPCs

The Light Arrows in The Minish Cap (which aren't needed to clear the game) are permanently missable if you don't get them before entering the Wind Tribe's house. This is the only thing that I can think of in a Zelda game, aside from the Deku Nut Glitch in OoT.---To err is human. To blame your computer for your mistakes is even more human.

But even if you miss them in the first quest (it IS possible to get them all in the first quest) you can just get them again in the second quest.---To err is human. To blame your computer for your mistakes is even more human.