That would suggest that /usr/local/cpanel/3rdparty/etc/php.ini in not on an ext2/ext3 file system. Looks like cPanel is forcing a chattr on the file, which fails because chattr may not work on non-ext2/ext3 file systems.

I would suggest that you log this as an urgent problem on bugzilla as it looks like a serious bug to me:http://bugzilla.cpanel.net

The CPanel is baed on a VPS. All works fine untill some days before ... when an update of the CPanel ... makes this proplem.. and for 5 days all the time the panel crash.
I will refer the possible bug.
Thank you .