neurons

The neurovasculaire unit (NVU) is composed of brain microvascular endothelial cells (BMECs) that form the Blood-Brain-Barrier (BBB), pericytes, neurons and glial cells. It regulates substance transport between blood and brain. BBB and NVU dysfonctions are associated with numerous neurological pathologies. Animal models are traditionally used in medical research but the Read more…

The first version of BIOMIMESYS Brain allows to form neurospheres. We now developped a new version of BIOMIMESYS Brain, which allows to form neuronal networks. This version have a higher porosity than BIOMIMESYS Brain (Neurosphere), that allows to better disperse the cells and thus to form cell network instead of Read more…

HCS Pharma is one of the winner of the Lab’StartUp village, organized by Forum Labo! As such, we have won a stand in the heart of the forum (March 26-28, 2019)… Thanks a lot to the committee for evaluating our application to this prize, and for selecting our new product Read more…

Sood et al. published in 2016 an interesting article about the effect of extracellular matrix (ECM) on in vitro neuronal cells culture: “Fetal brain extracellular matrix boosts neuronal network formation in 3D bioengineered model of cortical brain tissue “. The aim of the study was to study the effects of Read more…

We are developing a new BIOMIMESYS® hydroscaffold for neuronal cells. First results are very promising because neurons grow and form neurites. Moreover cells lived longer than in monolayer culture. We are currently finalizing this new hydroscaffold to find the best conditions of 3D neuron culture, but BIOMIMESYS® Brain will be soon Read more…

One third of the safety failures is linked to CNS toxicity during the clinical trials of drugs. In order to develop a more predictable in vitro human model for neurotoxicity testing, we have compared the sensibility of iPSC-derived neuronal cells and SH-SY5Y cell line (neuroblastoma-derived cell line) to a panel Read more…