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Novel Therapeutic Use for Modafinil

University of Arkansas for Medical SciencesUnited States

Abstract ID: 07-25

New Use Modafinil...

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MECHANISM OF ACTION

New therapeutic use for an existing drug

FULL DESCRIPTION

Application: Treatment of hyper-reflexia and spasticity. New therapeutic use for an existing drug

Modafinil is a eugeroic drug generally prescribed to treat narcolepsy and is marketed by Cephalon Inc. under the brand name Provigil®. It is not a stimulant and is often described as a "wakefulness promoting agent." The drug is sometimes prescribed off-label for ADD/ADHD. The drug is also marketed for improving 'alertness' and reducing 'excessive daytime sleepiness.' Modafinil is also used to treat excessive sleepiness caused by certain sleep disorders such as obstructive sleep apnea/hypopnea syndrome, and shift work sleep disorder.

Research has revealed a new-use for Modafinil for the treatment neurological disorders resulting from various neuro-pathological states. Data reveal that this drug works to treat hyper-reflexia and spasticity, which are non-voluntary and extended muscle contractions. These conditions arise following spinal cord injury, in cerebral palsy, following stroke and in multiple sclerosis and other neurological disorders. Current studies and unpublished work document a defined mechanism for the action of Modafinil in alleviating hyper-reflexia.

I07-25

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Type of Business Relationship Sought

Seeking partner to develop and commercialize this new use for Modafinil