The purpose of this study is to determine whether the administration of hyaluronic acid or corticosteroid during arthrocentesis of the temporomandibular joint provides additional pain relief and improved function.

The overall hypothesis for the study is that hyalgan will result in a 30% reduction in the mean visual analogue scale (VAS) at one month when compared to celestone and placebo.

This study will enroll patients with temporomandibular joint dysfunction who are deemed appropriate candidates for irrigation of their jaw joints secondary to pain or limited opening. At the completion of the joint irrigation subjects will be injected by one of three different products to determine if the additional injection results in a further decrease in jaw joint pain and improved opening. Subjects will be followed for 3 months. Those who do not show improvement may be candidates for additional treatment.

Eligibility

Ages Eligible for Study:

18 Years to 90 Years

Genders Eligible for Study:

Both

Accepts Healthy Volunteers:

No

Criteria

Inclusion Criteria:

age greater than 18 years

arthralgia of one or both temporomandibular joints

Wilkes II to IV internal derangement of the symptomatic joint OR

limited opening of <35 mm

Exclusion Criteria:

myofascial pain as the primary source of pain

cervical pain as the primary source of pain

systemic arthropathy

fibromyalgia

use of NSAIDS within 48 hours

allergy to study medications

edentulous subjects

pregnancy or breast feeding

current physical therapy, muscle relaxants or antiseizure medications

current use of a splint issued within last 12 weeks

Contacts and Locations

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study.
To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below.
For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01524913

Locations

United States, California

University California Los Angeles

Los Angeles, California, United States, 90024

United States, Georgia

Emory University

Atlanta, Georgia, United States, 30322

United States, Ohio

University of Cinncinati

Cinncinati, Ohio, United States, 45219

United States, Oregon

Oregon Health Sciences University

Portland, Oregon, United States, 97239

United States, Pennsylvania

University of Pennsylvania

Philadelphia, Pennsylvania, United States, 19104

Sponsors and Collaborators

Emory University

University of California, Los Angeles

Oregon Health and Science University

University of Minnesota - Clinical and Translational Science Institute