Abamune® is a potent medication used to treat HIV-1 infection in conjunction with other anti-retroviral drugs. Abamune® is not able to cure HIV-1 infection completely, it lowers the amount of virus in the infected body, and keeps it at a decreased level. Abamune® also promotes the white blood CD4 cells production, as they are important in fighting infection.

Indications:

MOA (mechanism of action):

Abacavir is a carbocyclic synthetic nucleoside analogue and an antiviral agent. Intracellularly, Abacavir is converted by cellular enzymes to the active metabolite carbovir triphosphate, an analogue of deoxyguanosine-5'-triphosphate (dGTP). Carbovir triphosphate inhibits the activity of HIV-1 reverse transcriptase (RT) both by competing with the natural substrate dGTP and by its interfering with the growth of viral DNA. Abacavir isn't active against HIV-2.

Dosage

Adults:

The recommended oral dose is 600 mg once daily (or 300 mg twice daily) in combination with other anti-retroviral agents.

Children over 3 months of age:

The recommended oral dose is 8 mg per kg twice daily or 16 mg per kg once daily (maximum 600 mg daily) in combination with other anti-retroviral agents.

Before taking Abacavir tablets, children should be assessed for the ability to swallow tablets.

Patients with mild hepatic impairment should take 200 mg twice daily.

Precautions:

Not everyone responds to treatment with Abamune® in the same way. Your doctor should monitor the effectiveness of your treatment.

HIV can be transmitted through sexual contact with HIV positive partner, blood (e.g., sharing needles, handling blood instruments, receiving blood transfusions, blood products, or organ/tissue transplants that were infected with HIV), childbirth, toiletries (razors and toothbrushes). Therefore, both HIV-positive and HIV-negative individuals are advised to have any kind of sex using a latex or polyurethane condom, avoid sharing needles or other things like toothbrushes or razors. It is important to discuss with doctor the precautions needed to avoid infecting other people as well as take precautions not to get infected.

Prior starting Abamune® tablets, review medical history for prior exposure to any abacavir-containing product (including Abacavir/Lamivudine, Abacavir/Dolutegravir/Lamivudine, and Abacavir/Lamivudine/Zidovudine) in order to avoid reintroduction in a patient with a history of allergy to Abacavir.

Prior to initiating therapy with Abacavir, screening for the HLA-B*5701 allele is recommended as this decreases the risk of allergic reaction. The carriars of the HLA-B*5701 allele are at a higher risk of a hypersensitivity reaction to Abacavir.

Never restart Abamune® or any other abacavir-containing product following allergic reaction to Abacavir, regardless of HLA-B*5701 status.

Reintroduction of Abamune® or any other abacavir-containing product, even in patients who have no identified history or unrecognized symptoms of allergy to Abacavir therapy, can result in serious or fatal hypersensitivity reactions. Such reactions can occur within hours.

Take special care if you have moderate or severe liver disease, you have ever had liver disease, including hepatitis B or C, you are seriously overweight (especially if you are a woman), you have severe kidney disease.

Consult doctor before taking if you are taking phenytoin (for treating epilepsy), methadone (as a heroin substitute). Abacavir speeds up the removal of methadone from the body. If you are taking methadone, you will be checked for any withdrawal symptoms. Your methadone dose may need to be re-elevated.

Women who are HIV-positive must not breastfeed because HIV infection can be passed on to the baby in breast milk.

Missing a dose

If you miss a dose you should take it as soon as you remember about your missing. If it is the time for the next dose you should continue your regular dosing schedule. Do not take a double dose of Abamune® to compensate the missed dose.

Overdose

If an overdose occurs and you are not feeling well, stop taking the medication immediately. You should seek emergency medical attention or contact your healthcare provider immediately.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) and away from excess moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects occurrence does not only depend on the medication you are taking, but also on your overall health and other factors.

Contraindications

Abamune® is contraindicated in patients who are allergic to Abacavir, any other medication containing Abacavir (e.g., Trizivir, Triumeq or Kivexa), or any of the other ingredients of Abamune®.

Abamune® is contraindicated in patients who carry the HLA-b*5701 allele because they are at high risk for experiencing allergy to Abacavir.

Abamune® is contraindicated in patients with heart disease, high blood pressure, liver disease, a risk factor for heart disease such as smoking, diabetes, or high cholesterol, or if you have used any other HIV medication in the past.

Never restart Abamune® or any other abacavir-containing product following allergic reaction to Abacavir, regardless of HLA-B*5701 status.

Abamune® is contraindicated in patients with moderate or severe hepatic impairment.

Do not take Abamune® if you are pregnant or plan to have a baby without prior consulting with your healthcare provider.

Women who are HIV-positive must not breastfeed because HIV infection can be passed on to the baby in breast milk.

A: Abamune® is a potent medication used to treat HIV-1 infection in conjunction with other anti-retroviral drugs. Abamune® is not able to cure HIV-1 infection completely, it lowers the amount of virus in the infected body, and keeps it at a decreased level. Abamune® also promotes the white blood CD4 cells production, as they are important in fighting infection.

Q: Is Abamune® safe?

A: Abamune® is safe if taken as prescribed by your doctor.

Q: Is Abamune® safe during pregnancy?

A: Do not take Abamune® if you are pregnant or plan to have a baby without prior consulting with your healthcare provider.

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