In the latter episode, she travels to Peru to experiment with the controversial psychedelic Ayahuasca - a plant drug found in the Amazon that is taken as a tea and supposed to induce an out-of-body experience - and promptly vomits on camera from its effects.

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Here goes nothing: Chelsea Handler is seen taking the controversial plant drug Ayahuasca for the first time in her new Netflix documentary series, Chelsea Does, which premieres this weekend

Ceremony: Ayahuasca retreats have become incredibly popular in Peru, where visitors can experience the drug in a ceremony overseen by a shaman (left)

'It’s supposed to be one of those transformative experiences; people say it changes their life,' Handler said

Unpleasant: The 40-year-old explains in the show that most people vomit straight after ingesting the tea, and she was no different

As part of the episode, Handler, 40, openly discusses her 'close relationship with drugs' and how she has 'experienced so many'.

However she had never tried Ayahuasca, and found its mysticism attractive.

'It's supposed to be like this spiritual awakening drug, transformative, transcendent in certain ways,' she said on Jimmy Fallon this week while promoting the show.

WHAT IS AYAHUASCA?

Ayahuasca, or yage, contains Dimethyltryptamine, known as DMT.

Used in South America, especially in the Amazon basin, Ayahuasca is a drink produced from the stem bark of the vines Banisteriopsis caapi and B. inebrians.

It is said to have healing properties and bring inner peace by purging toxins and can produce reactions including vomiting.

Psychedelic experiences last six to 10 hours and are guided by experienced shamans in the South American countries where ayahuasca is legal and native to consume.

'I want to show people what happens when you get f--ked up.

'We went down to Peru and we did it. You vomit out of your mouth and out of...' she trailed off, gesturing behind her, before adding: 'And Netflix paid for it, thank you guys.'

As the drug has grown in popularity, many retreats have popped up in Peru, where tourists can pay to try Ayahuasca in a 'safe environment'.

The brew - made from the Banisteriopsis vine mixed with the leaves of plants that contain dimethyltryptamine (DMT) - is typically taken in a ceremony overseen by a shaman, with users sitting on mattresses and under close watch by staff.

'It’s supposed to be one of those transformative experiences; people say it changes their life,' Handler said.

'You drink it, its like a tea, you do it with some guy who's yelling at you in Spanish. He's got trees, and if you're not focusing he'll hit you on the head.

'I'm like "I'm trying to get high too! Why are you yelling at me?"

Chelsea Handler traveled to Peru to experiment with the with the controversial psychedelic Ayahuasca

Handler further explained to The New York Post: 'I didn’t feel anything the first night … so of course I had to take [the Ayahuasca] a second night with a shaman.'

'There was a lot of chanting and vomiting on camera for me, which of course I was very excited to do.'

Also talking to Ellen about the experience this week, Handler said she did indeed have the hallucinations, or visions, many claim to when taking Ayahuasca.

'I had all these beautiful imageries of my childhood and me and my sister laughing on a kayak, and all these beautiful things with me and my sister,' she said.

'So (my experience) was very much about opening my mind to loving my sister, and not being so hard on her.'

However the drug- which is illegal in the United States, has been linked to the deaths of many tourists in South America.

There have also been reports of molestation, rape and negligence at the hands of some shamans.

Late last year, a Canadian man killed a British banker who attacked him during a bad hallucination on Ayahuasca in Peru.

Joshua Stevens, 29, from Canada, stabbed Cambridge graduate Unais Gomes after Gomes, 26, after taking the drug at a spiritual retreat in December.

British banker Unais Gomes (left) was stabbed to death at an Ayahuasca retreat in Peru in December by Canadian man Joshua Stevens (right), who said Gomes first attacked him with a knife during a hallucination

Stevens said Gomes had taken a 'double dose' of the hallucinogenic brew and attacked him with a knife.

Stevens then managed to get to the knife after a struggle.

He told Winniepeg CTV News: 'What I was saying to myself is, 'if he gets this knife back, he's either going to kill me or the other two men here. That's when I made the decision to stab him.'

'I really thought I was going to die.'

Stevens was taken into custody but later released without charge.

Local police said he acted in self defense, and that there was no evidence suggesting he had taken any drugs at the retreat.

Handler's exploration of drugs did not stop in the Amazon - she took the sleeping pill Ambien while drinking, under the supervision of doctors, to 'show people the effects'.

She also took Athe DHD medication Adderall - often called the 'smart drug' - hosted a dinner where each course was infused with marijuana, and smoked weed with Willie Nelson.

'I was so stoned': Also in the episode, Handler sits down with Willie Nelson to smoke weed and interview the country music legend about his love of pot

'Oh my God, I was high for two days! I literally couldn't open one of my eyes,' Handler told Fallon of her interview with the 82-year-old country legend.

'He has his own line of weed, for those of you who like weed. I was in a trailer with him - I think he lives in a trailer... he was so stoned he probably didn't even know I was there.'

However it wasn't all fun and games. After all, Handler was supposed to be working.

'The worst part was, as an interviewer I'm supposed to be interviewing him,' she said.

'I'm talking to him and I didn't take into account that I was going to be completely disabled,' she said.

'So as we're talking I am like "Oh my God - what am I going to say next?"

'I was like: just keep talking!... looking at him, and he's not a big talker... so I was just like "I hope he keeps talking"... I'm so stoned.

Chelsea Handler is seen out in New York on Tuesday night. The comedian is on a promotional tour for her new Netflix show

Sign here: She signed autographs for waiting fans as she made her way to a taping of Jimmy Fallon

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Handler also discussed the marriage episode of her series, explaining why she's never tied the knot.

'I've never been married and I think that's a victory,' she said.

'I feel like now that I'm 40, I can see getting married. I mean, I've no viable options at all. But now that I'm passed the hump of people saying "when are you going to get married?" - 'cause I was so rebellious I was like "I'm not gonna marry anybody!"

'And no that no one is asking me I'm like "watch me get married! I'll get married, I'll get divorced and then I'll get married again - booyah!'

Chelsea Does debuted at the Sundance Film Festival this week, and will hit Netflix January 24.

EXPERIENCING THE HIGH: TRYING AYAHUASCA

'My first time was a magical experiences. It was like being in the most exquisite, cosmic, carnival ride in the universe. I laughed with wonder, I cried with an open heart, I wanted to do more…,' author Carina Cooper writes for High50, adding that the experience turned sinister the second time

'I had a vision of a drawer opening out from under my heart. In this drawer was a heart with all its tubes etc pulsating. An angelic voice said to me in a gentle whisper, 'You are now going to feel all the pain you have shut away.'

'I sobbed for about five hours (ceremonies generally start around 8pm and can go on until dawn) deep guttural, physical sobs.'

Ted Mann wrote in a Vanity Fair article about his experience in 2011, detailing his vivid visions and experience.

'Every detail of a vast cliff face, an open-pit mine, composed of copulating salamanders, is presented and recognized and responsive to sound continuously evolving, by what seems like a logical progression, into the detailed hues of the internal organs—this makes me vomit.

'The visions resume with newcomers, self-dissecting aliens presenting themselves, and their internal anatomy, in the turning pages of an abnormal-physiology textbook, published on sheets of fundamental matter, quarks and gluons, massless constituents of the infinitesimal, actually becoming the things they appear to represent.

'My visions continue for several hours, and I await with trepidation further instruction, a formal conclusion, or some apocalyptic visionary summation. I am not disappointed when, instead, I realize it's over.'