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Hyperthermia

It is well established that heat can damage healthy tissue, but lower temperature heat, ranging from 37oC to 42oC (98.6oF to 108oF), can weaken and kill cancer cells while minimizing the impact on healthy tissue. This basic concept of treating cancer with low-temperature heat is called ‘hyperthermia’.

Endomag is developing therapeutic hyperthermia systems as an adjuvant to chemo- and radiotherapy using magnetic nanoparticles and external field generators. While adjuvant heating is applicable to many cancer types, the first indication under development is the treatment of non-muscle invasive bladder cancer.

Prototype systems have been validated by two pre-clinical in vivo studies, including Duke University Medical Centre and an independent contract research facility. The studies successfully demonstrated that the systems are able to achieve well-defined therapeutic temperatures in the bladder using a catheter-introduced magnetic nanoparticles and a safe, external magnetic field.