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Cyborg is the story of an astronaut and test pilot, Steve Austin, who experiences a catastrophic crash during a flight, leaving him with all but one limb destroyed, blind in one eye, and with other major injuries.

At the same time, a secret part of the American government, the Office of Strategic Operations (OSO) has taken an interest in the work of Dr. Rudy Wells concerning bionics - the replacement of human body parts with mechanical prosthetics that (in the context of this novel) are more powerful than the original limbs. Wells also happens to be a good friend of Austin's, so when OSO chief Oscar Goldman "invites" (or rather, orders) Wells to rebuild Austin with bionics limbs, Wells agrees.

Steve Austin is outfitted with two new legs capable of propelling him at great speed, and a bionic left arm with almost human dexterity and the strength of a battering ram. One of the fingers of the hand incorporates a poison dart gun. His left eye is replaced with a false, removable eye that is used (in this first novel) to house a miniature camera. Other physical alterations include the installation of a steel skull plate to replace bone smashed by the crash, and a radio transmitter built into a rib. This mixture of man and machine is known as a cyborg, from which the novel gets its title.

The first half of the novel details Austin's operation and both his reaction to his original injuries—- he attempts to commit suicide—- and his initially resentful reaction to being rebuilt with bionics. The operation has a price: Austin is committed to working for the OSO as a reluctant agent. The second half of the novel describes Austin being teamed with an already experienced female operative, and his mission to the Middle East as both spy and weapon. Austin, already coming to appreciate his bionic implants, relies heavily on his augmentation during the mission and by the end accepts his role.

Caidin's book was written as the first of a series, and during the next few years, he wrote three more books that were, for the most part, independent of the continuity of the television series (upon which additional novels were written by other authors):

During 1973, Cyborg was adapted as a 90-minute, made-for-television movie titled The Six Million Dollar Man. The movie begins with a computerized text scroll explaining the term "cyborg" and since the word "CYBORG" is the first word seen on screen, some sources, including the ABC network's own promotions for the movie and later Discovision home video release, give the full title as Cyborg: The Six Million Dollar Man.

The movie featured Lee Majors as Austin and Martin Balsam as Rudy Wells. For reasons unknown, it was decided to change the name of the OSO chief to Oliver Spencer (played by Darren McGavin). Real-life footage of a test-plane crash was incorporated into the movie to depict Austin's accident.

The first half of the movie follows Cyborg fairly well, including Austin's initial suicide attempt and Wells' reluctance to operate on his friend. The second half of the movie differs from the novel, with Austin dropped into a remote part of Saudi Arabia on a solo mission and ordered to rescue a prisoner from a group of extremists, a mission later revealed to be a test of Austin's abilities.

The movie was a ratings success. A second movie, Wine, Women and War was commissioned, but this was not based upon a Caidin work. For this second movie, Oscar Goldman was reinstated (with Richard Anderson playing the role), but the agency was renamed the Office of Scientific Intelligence (OSI).[1]Alan Oppenheimer replaced Martin Balsam as Dr. Wells. A third TV movie, Solid Gold Kidnapping followed, after which The Six Million Dollar Man was begun as a weekly television series during 1974, running until 1978 for a total of five seasons. The original pilot movie was re-edited with new footage to make it a "flashback episode" and syndicated as the two-part "The Moon and the Desert". Author Martin Caidin, according to The Bionic Book by Herbie Pilato, served as an uncredited consultant for the series throughout its run, and ultimately made a brief appearance in one of its final-season episodes; in addition, author Jay Barbree, who collaborated with Caidin on a number of nonfiction book projects, also wrote a novel based upon the series.

During 1976, a spin-off, The Bionic Woman, was begun, playing also until 1978, or three seasons. During 1987, 1989, and 1994, three made-for-television movies reunited the casts of both series. Due to his licensing agreement with Universal Studios, Caidin received credit on all these productions, though The Bionic Woman did not originate from his books. The Bionic Woman was remade during 2007 as Bionic Woman, although few elements from the 1976-78 series were retained; elements from Cyborg, however, were incorporated, such as the imagined Jaime Sommers possessing a bionic eye - a feature invented by Caidin for Austin - and organizational similarlities between the OSO of Caidin's novel and the movie, and the Berkut Group organization featured in the remake. Only nine episodes of the remake were produced.

A number of changes to Austin's bionic abilities and his demeanor were made as Caidin's original novel and its concepts were modified.

To increase the science-fiction appeal, Austin's bionics were made more powerful, and he had abilities his literary counterpart lacked. Most notably, the first movie revealed that Austin's replacement bionic eye had a telescopic feature (later expanded to include night vision), whereas Caidin originally had Austin's eye be little more than a minicamera (and the character was still blind in it). Although his bionic eye is shown before implantation and Austin is later shown using both of his eyes for normal vision, the movie otherwise omits any demonstration of the eye's special abilities. (The comic book adaptation of The Six Million Dollar Man added even more functions to the eye; in the first issue, Austin shoots a laser out of the eye, while in a later issue, its telescopic function is so advanced, he is able to see a man standing on a streetcorner from dozens of miles away.)

Austin was made to be less unemotional in the television series. In the novel (and those that followed), Caidin depicts Austin as being prepared to kill without pause during his missions - for example, he kills a truck driver to prevent the man from identifying Austin to the enemy. The television version, however, is shown stating outright that he has no desire to kill people (although he still does, on occasion), and tools such as the poison dart gun in the bionic arm were omitted. Also, since actor Majors was right-handed, it was decided that Austin's bionic arm would be his right, not his left as depicted in the novels (this discrepancy resulted in the cover art of some editions of the novels showing a bionics left arm and others a right; see, for example, the 1978 cover art depicted above the infobox). In Caidin's novel, the bionics arm was essentially a bludgeon and battering ram (Austin is frequently described crushing skulls with it during fight sequences); in the televised version, the arm is more sophisticated and Austin is shown bending bars and throwing objects great distances with it.

In the novel, Austin is described as having a military and astronaut background. In the movie adaptation, he is explicitly described as a civilian test pilot (although also a former astronaut). For the television series, Austin's career was changed to match that of the books, and he was given the rank of US Air Force colonel.

Despite the changes made to the character for television, when authors such as Mike Jahn and Evan Richards were commissioned to write novelizations based upon Six Million Dollar Man episodes, they chose to follow Caidin's original model of the character, which on at least one occasion (the adaptation of "Love Song For Tanya" contained within Jahn's book, International Incidents) resulted in the ending of an episode being changed (in the episode, the villain is apprehended by Austin and arrested; in the book, Austin simply fires his poison dart gun at him and kills him).

The Six Million Dollar Man produced two comic book adaptations beginning during 1976, both from Charlton Comics - a color monthly comic and a black and white illustrated magazine. Both included condensed adaptations of the Cyborg origin story in their first issues; Power Records also retold the story of Cyborg for one of its illustrated book-and-record sets also during 1976. More recently, the original novel - as well as the television series - informed a new adaptation of Cyborg, The Bionic Man, published by Dynamite Comics during 2011-2012, based upon an unproduced screenplay by Kevin Smith; during 2012, the comic began featuring original stories. During 2014, Dynamite replaced this series with The Six Million Dollar Man Season Six, a limited-run series chronicling the adventures of Steve Austin after the TV series. In 2016, this was succeeded by a miniseries (ostensibly also set after the TV series), titled Fall of Man.

During the 1990s, Caidin wrote the novel Buck Rogers: A Life in the Future based upon the Buck Rogers comic strip of the 1930s. In this book, Caidin pays tribute to Cyborg by having Buck Rogers receive bionics transplants after his 500-year coma, including several direct references to Steve Austin himself.

Cyborg was not Caidin's first reference to bionics, as the concept is also discussed in his 1968 novel, The God Machine. Caidin also revisited the concept in his 1982 novel Manfac, ISBN 0-671-65409-8, ISBN 978-0-671-65409-2, which even included dialog that derisively referred to the Six Million Dollar Man series.

^Other definitions for the acronym, such as Office of Strategic Intelligence, have also appeared, usually in spin-off media, but Office of Scientific Intelligence is the form as actually displayed on screen