When a male has the defining traits that make him manly removed, typically via marriage or long term relationship to a much more dominant woman. These qualities usually include the ability to think or dress for himself, having his leisure time replaced with shopping or chores, and/or no longer having a spine.

The Kardashians have performed a successful manectomy on Bruce Jenner.

My friend was totally cool before he got engaged. Now he has to ask permission to leave the house. I think he has to stay close so that he doesn’t lose his penis, which is in a jar.