GPP Web Portal - Welcome

The Genetic Perturbation Platform, formerly known as the RNA interference (RNAi) Platform, supports functional investigations of the mammalian genome that can reveal how genetic alterations lead to changes in phenotype.

GPP develops technologies for perturbing genes and assists collaborators in experimental planning and execution by helping choose the best
model system and experimental readout to assess the effects of genetic perturbation. Technologies include libraries of short hairpin RNAs
(shRNAs), CRISPR/Cas9 constructs, and open reading frames (ORFs) to knock down or overexpress genes, in addition to other techniques such as
TALEN and CRISPR/Cas9 for genome editing and "tough decoy" constructs to inhibit microRNAs.