He has posted a team-leading 108 special teams tackles since joining the Eagles, including a career-high 35 in 2006. As such, Mikell has been voted by his teammates as the Eagles special teamsMVP in 2005 and 2006.

On defense, Mikell replaced the injured Sean Considine as the starting strong safety in 2007 and remained in that role through 2010.

On November 28, 2004, Mikell notched his first career interception, outjumping tight endJeremy Shockey in the end zone for a pass thrown by quarterbackEli Manning late in the first half vs. the New York Giants. The play helped the Eagles preserve a 7-6 lead at halftime, and Philadelphia went on win, 27-6, to clinch their fourth consecutive NFC East title.

His most significant contribution on special teams came on October 23, 2005, when, with the Eagles trailing the San Diego Chargers, 17-13, late in the fourth quarter, he blocked a field goal attempt by placekickerNate Kaeding (who to that point had not missed a field goal all season), which teammate Matt Ware returned 65 yards for a touchdown to secure a 20-17 win. It was the first time in Eagles history that a blocked field goal was returned for a touchdown.

Mikell was signed by the Carolina Panthers on September 2, 2013 to a one-year contract. Safety Haruki Nakamura was placed on injured reserve to open up spot on the 53-man roster. Mikell is expected to compete for the starting job at strong safety.[2]