Abstract

The main objectives of this study were (1) investigation of the temporal variations of ambient fine particulate matter (PM; 2.5; ) and ground level ozone (O; 3; ) concentrations in Tehran megacity, the capital and most populous city in Iran, over a 10-year period from 2006 to 2015, and (2) estimation of their long-term health effects including all-cause and cause-specific mortality. For the first goal, the data of PM; 2.5; and O; 3; concentrations, measured at 21 regulatory monitoring network stations in Tehran, were obtained and the temporal trends were investigated. The health impact assessment of PM; 2.5; and O; 3; was performed using the World Health Organization (WHO) AirQ+ software updated in 2016 by WHO European Centre for Environment and Health. Local baseline incidences in Tehran level were used to better reveal the health effects associated with PM; 2.5; and O; 3; . Our study showed that over 2006-2015, annual mean concentrations of PM; 2.5; and O; 3; varied from 24.7 to 38.8 μg m; -3; and 35.4 to 76.0 μg m; -3; , respectively, and were significantly declining in the recent 6 years (2010-2015) for PM; 2.5; and 8 years (2008-2015) for O; 3; . However, Tehran citizens were exposed to concentrations of annual PM; 2.5; exceeding the WHO air quality guideline (WHO AQG) (10 μg m; -3; ), U.S. EPA and Iranian standard levels (12 μg m; -3; ) during entire study period. We estimated that long-term exposure to ambient PM; 2.5; contributed to between 24.5% and 36.2% of mortality from cerebrovascular disease (stroke), 19.8% and 24.1% from ischemic heart disease (IHD), 13.6% and 19.2% from lung cancer (LC), 10.7% and 15.3% from chronic obstructive pulmonary disease (COPD), 15.0% and 25.2% from acute lower respiratory infection (ALRI), and 7.6% and 11.3% from all-cause annual mortality in the time period. We further estimated that deaths from IHD accounted for most of mortality attributable to long-term exposure to PM; 2.5; . The years of life lost (YLL) attributable to PM; 2.5; was estimated to vary from 67,970 to 106,706 during the study period. In addition, long-term exposure to O; 3; was estimated to be responsible for 0.9% to 2.3% of mortality from respiratory diseases. Overall, long-term exposure to ambient PM; 2.5; and O; 3; contributed substantially to mortality in Tehran megacity. Air pollution is a modifiable risk factor. Appropriate sustainable control policies are recommended to protect public health.