At least 453 people have been killed and nearly 720 others injured in a crush during Hajj pilgrimage rituals outside Mecca.

According to Saudi disaster officials, the incident occurred in Mina, near Mecca, at 9 am local time (0600 GMT) after two large masses of pilgrims coming down streets 204 and 223 fused together.

The incident took place as people were heading to participate in the symbolic stoning of Satan.

Over 220 ambulances and 4,000 rescue workers have reportedly been sent to the location.

“Work is underway to separate large groups of people and direct pilgrims to alternative routes,” the Saudi Civil Defense said.

‘Iranians among the dead’

Meanwhile, Sa’eed Ohadi, the head of Iran’s Hajj and Pilgrimage Organization, has said that at least 43 Iranians have been killed and 60 others wounded in the crush, according to ISNA.

Separately, an Iranian deputy foreign minister has announced that a special commission has been set up by the Islamic Republic to follow up on the case of the Iranian pilgrims in Mina.

‘Saudi authorities responsible’

Hossein Amir-Abdollahian, Iran’s deputy foreign minister for Arab and African affairs, said the Iranian Embassy in Saudi Arabia, the Consulate and all other relevant organizations are actively working to determine the fate of the Iranian victims of the Thursday incident.

Amir-Abdollahian held the Saudi authorities responsible for the deadly incident, and said they should promptly act to manage the crisis.

“The imprudence on the part of relevant Saudi authorities to provide security for the pilgrims cannot be ignored,” he said.

Some two million people are currently in Mecca for this year’s Hajj pilgrimage.

Some 360 pilgrims lost their lives during the same ritual in Mina back in January 2006

This comes days after a massive construction crane collapsed into Mecca’s Grand Mosque, killing more than 100 people and leaving over 200 others wounded.

Separately, on September 21, a fire at a 15-story hotel in Mecca forced the evacuation of some 1,500 people. A fire also broke out at another hotel in the city days earlier, which left a number of foreigners injured.