You could try it if you want but in my experience if Symantec does not support it it is because it won't work right. If it is requiring short names support it is most likely because that is what the program uses. If you turn it off then new files will not get indexed with short names and you would start to have issues with the program.

This is just an educated guess however. For the technical answer you would want to contact Symantec support.

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