playing a potential role in the pathogenesis of rheumatoid arthritis, where its induction upon tissue injury creates a perpetual destructive cycle

role of tenascin-C as a regulator of the fibrinolytic system

potential role for this protein in vascular morphogenesis, in matrices of injured and tumor tissues

is a critical component of the bone marrow microenvironment that is required for hematopoietic regeneration

matricellular protein expressed during embryonic development, as well as in wound healing and cancer invasion in various tissues, and may regulate cell behavior and matrix organization during tissue remodeling

TNC and tenascin-R (TNR) play important roles in cell proliferation and migration, fate determination, axonal pathfinding, myelination, and synaptic plasticity

in cell interactions during development and, in the adult, in synaptic activity and plasticity, as well as regeneration after injury, TNC is conducive for regeneration and TNR is inhibitory for functional recovery

interacting with NT5E (a novel and specific receptor for tenascin C and the interaction between these proteins may influence cell adhesion and migration and also lead to decreased generation of local adenosine)

polymorphisms might play a more independent role for development of upper airway disease such as rhinoconjunctivitis, whereas for asthma, the interplay with other genes, like NPSR1, becomes more prominent