The New England Patriots are the biggest favorites on the NFL schedule for a second straight week, and the Buffalo Bills are expected to have a big win, as well. With the Miami Dolphins and New York Jets playing like two of the league’s worst teams, the four biggest betting lines of Week 6 come in games involving the AFC East.

Following their 20-point win in Tom Brady’s return from his suspension, New England is an 8.5-point favorite over the visiting Cincinnati Bengals. Returning home on a three-game winning streak, the Bills are giving eight points to the San Francisco 49ers. The Jets and Dolphins are both 7.5-point underdogs.

The AFC West might be the NFL’s toughest division, and it could produce two of the best games in Week 6. The Denver Broncos are favored over the San Diego Chargers by just a field goal, and the contest between the Kansas City Chiefs and Oakland Raiders features the week’s smallest point spread.

The biggest over/under of Week 6 comes in the Pittsburgh Steelers’ visit to Miami. The game between the Los Angeles Rams and Detroit Lions is expected to be the lowest-scoring affair.

Betting odds for the game between the Carolina Panthers and New Orleans Saints might not be set until later in the week when more is known about Cam Newton’s status. The quarterback missed Carolina’s last game with a concussion, and the defending NFC champions dropped to 1-4 on the 2016 season.

The Minnesota Vikings are the only unbeaten team in the NFL, but they are off in Week 6. The Tampa Bay Buccaneers also have a bye.

Below are the complete betting lines for all the Week 6 games, including the point spreads and totals. These are the consensus odds from multiple sportsbooks in Las Vegas and online, via OddsShark.

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