USDA Chief Veterinary Officer John Clifford, CDC Medical Officer Dr. Alicia Fry and USDA Southeast Poultry Research Director David Swayne will provide an update on the recent outbreaks, current U.S. and State government response efforts, and research efforts underway for a vaccine.

Wednesday, April 22, 201511:00 a.m. – 11:45 a.m. EDT

WHAT: USDA and CDC will provide an update on current HPAI H5N2 response.

Clade 2.3.4.43 viruses were detected in birds in Canada, Germany, Italy, Japan, Netherlands, Republic ofKorea, Russian Federation, United Kingdom, USA and Viet Nam, and in birds, environmental samplesand two humans in China. There was considerable diversity in the HA genes of these clade 2.3.4.4 virusesand in the subtype of neuraminidase (NA) with which they were paired (Figure 2). The A(H5N6/N8)viruses isolated in China, the A(H5N6) viruses from Viet Nam and previously characterized A(H5N6)viruses from Lao People’s Democratic Republic were antigenically diverse although ferret antisera raisedagainst viruses similar to A/Sichuan/26221/2014 (H5N6), from which a CVV is in development, reactedwith most viruses across this group (Table 3). The HA gene sequences of viruses isolated in Canada,Germany, Italy, Japan, Netherlands, Republic of Korea, Russian Federation, United Kingdom, USA andsome of the viruses from China clustered together, although there was considerable diversity in thesequences of the other viral genes. This diversity was highlighted by the introduction of the A(H5N8)virus into North America and by subsequent reassortment with North American lineage avian virusesgenerating novel A(H5N1) and A(H5N2) viruses. The antiserum raised against anA/Sichuan/26221/2014-like virus did not react well with A(H5N2/N8) viruses isolated in the USA (Table4). Conversely, ferret antisera raised against A/gyrfalcon/Washington/41088-6/2014 (H5N8) andA/chicken/Kumamoto/1-7/2014 (H5N8) did not react well with the A/Sichuan/26221/2014 (H5N6)-likevirus. A new CVV based on an A/gyrfalcon/Washington/41088-6/2014-like virus is proposed.

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