Cellular and humoral immunity in HIV vaccines: Can we have it all?

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Nicole Frahm, Ph.D., is the Associate Director for Laboratory Science of the HIV Vaccine Trials Network and holds an Assistant Member appointment at the Fred Hutchinson Cancer Research Center as well as an Assistant Professor appointment at the University of Washington. She received her PhD in Immunology at the University of Hamburg, Germany, and completed her post-graduate work with a joint appointment at Massachusetts General Hospital and Harvard Medical School in Boston, Massachusetts. During her career, Dr. Frahm studied the influence of HIV sequence diversity on its recognition by cytotoxic T lymphocytes, as well as the factors governing the recognition of sequence variants both in HIV-infected subjects and in vaccine trial participants. In her role as the Associate Director for Laboratory Science she provides leadership and scientific support for the HVTN Laboratories. This includes oversight of the Endpoints Laboratory, which is responsible for the generation of validated cellular immunogenicity data for all HVTN trials, and of the R&D Laboratory, which provides ancillary and exploratory data leading to a more complete view of the immune responses generated by HIV vaccines. Dr. Frahm has published more than 50 peer-reviewed manuscripts.