The character of Mysterio, aka Quentin Beck, was introduced into the comics by Stan Lee and Steve Ditko in 1964.

Anyone who's seen "Avengers: Infinity War" knows (spoiler alert!) that several of Earth's mightiest heroes were turned to dust when Thanos (Josh Brolin) finally completed his gauntlet and snapped his fingers, effectively killing half of the inhabitants of the galaxy, including Spider-Man (Tom Holland).