The effect of different adrenergic blockers on pulmonary edema induced by trauma to skull have been studied in mice. Propranolol (beta blocker) prevented pulmonary edema induced by trauma to skull whereas tolazoline (alpha blocker) as well as guanathedine (adrenergic neuron blocker) did not prevent pulmonary edema. Since propanolol is not having the property to prevent the increase of pulmonary capillary pressure induced by sympatho-adrenal storm due to trauma to skull. possibly It might have prevented the Pulmonary edema by blocking the primary increase of capillary permeability.