Description

The phosphorylation of myelin basic protein (MBP) has been shown to decrease the ability of MBP to aggregate lipid vesicles and consequently destabilising the compact structure of myelin, a destruction that has been observed in demyelinating diseases such as Multiple Sclerosis. (Yon, M et al. 1995) Clone 98/P12 is a useful detector of phosphorylated MBP by binding to Thr98 of human MBP in the phosphorylated state.

Debruin, Lillian S., Jeffery D. Haines, Dorothee Bienzle, and George Harauz. “Partitioning of Myelin Basic Protein into Membrane Microdomains in a Spontaneously Demyelinating Mouse Model for Multiple SclerosisThis Paper Is One of a Selection of Papers Published in This Special Issue, Entitled CSBMCB Membrane Proteins in Health and Disease.” Biochemistry and Cell Biology 84.6 (2006): 993-1005. WB, Dilution used 1:1000