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Need help with horse that is losing balance and running in circles

I am seeking any assistance if anyone has had similiar symptoms with thier horse. I have an 18 yr old quarter horse that was saved from a meat auction. He was in excellent high condition, almost appeared to be on steriods, extremely muscular etc. He eats very well, maintains a beautiful coat, he has lost some muscle but still in amazing condition. I have had several vets work on him, spend money on EPM medications and still nothing is working and no real diagnosis. He is getting worse, today he was running in circles and then fell down, when he got back up he was confused and couldn't find his way to me. I am wanting to do all I can for him and I am wondering if he was on steriods for a reason? any help would be a blessing for this guy.

it was "Marquis" paste, each tube was 300.00, we gave him two rounds. I agree as I am being very careful to be around him as he is getting much worse very quickly. I have had him for 4 years, and it I have worked on different diets, we have tried acupuncture but for some reason he has taken a severe turn for the worse just in the last few weeks and I can't figure it out. I will definitely do the right thing for him, but I wanted to make sure I haven't missed something completely obvious....

The vets are perplexed, at this time he is unable to be trailered due to the severity of his condition as the vets wanted to take him to the CU vet hospital, we are trying to get him "stable" just hoping someone out there has dealt with somthing similiar

This sounds like an extremely severe neurological problem, and a horse that needs a complete workup by a specialist. It is very unlikely that being on steroids would make him ill 4 years later.
Was this horse ever actually tested for EPM? What about other infectious diseases that can cause neuro problems? Has he had any cervical spine radiographs?

This sounds like a case that has never been properly managed. I hope you can get this horse some help, but it sounds like he is in a bad way at this point. Please be extremely careful - neuro horses are unpredictable because they don't always know where their body is in space.

I am not sure what you mean by "2 rounds of Marquis." Do you mean you gave him 2 tubes? Or was he on it for 2 months? If he has EPM, he may get worse during the treatment before he gets better. However, it does not sound good at this point. Has he had neuro issues for 4 years or have they just started?

I am seeking any assistance if anyone has had similiar symptoms with thier horse. I have an 18 yr old quarter horse that was saved from a meat auction. He was in excellent high condition, almost appeared to be on steriods, extremely muscular etc. He eats very well, maintains a beautiful coat, he has lost some muscle but still in amazing condition. I have had several vets work on him, spend money on EPM medications and still nothing is working and no real diagnosis. He is getting worse, today he was running in circles and then fell down, when he got back up he was confused and couldn't find his way to me. I am wanting to do all I can for him and I am wondering if he was on steriods for a reason? any help would be a blessing for this guy.

It sounds like when you got him he was very beefy looking, very muscled "like he was on steroids"?? My first thought was HYPP.

The vet did a complete blood work up first, then after observing him she felt confident that it was EPM, the blood work on that came back as unclear, so we decided to invest in it and worth a try if it worked.

We have had 2 other vets come out and everyone has a different opinon and direction they want us to go in, including the high protein diet, the acupuncture and that actually did make some improvements, He is under no stress, pastured with an older horse so life is very easy for him. So for the past 4 years he has been completely stable, just in the last 30 days we have seen this remarkable change and onset...very unusual so we are back to square one and will start over including a spinal tap which is what they suggest next?

yes the vet suggested we do 2 tubes each one is like 30 day treatment I believe. We saved him from a meat auction, we realize that many horses are there for a reason, so most likely his previous owner was relinquishing him for that reason. What is absolutely key here, is this horse is muscled up, appears healthy in every aspect, beautiful coat, eats well, absolutely exceptional, does not appear to be in pain or distress..that is why I am trying hard to figure out. Trial and error with vets can be very, very expensive, so I like to obtain all info I can before moving on to next step which is the spinal fluid tap....