She appeared when a young Bart was staying at the Flanders house while Marge was giving birth to Lisa. He was walking down a hallway at night when he ran into Grandma Flanders, who scared him by saying "Can you help me with my psalms?". When Ned walked in, she referred to him as "Joe".[2]

Some years later, she was responsible for babysitting Bart and Lisa along with Rod and Todd while their parents went to brunch together. She appeared to die, leaving the children unsupervised, but Dr. Hibbert later informed the Flanders family that she just barely survived. However, she was so weak that just hearing Ned's songs of praise was enough to actually kill her, according to Homer.[1]