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As a global market leader with numerous subsidiaries and distributors, Miltenyi Biotec is
committed to providing our customers around the world with the highest quality products.
In addition to direct selling in more than 20 countries in North America, Europe and
Asia/Pacific, Miltenyi Biotec also provides support for our customers through an
extensive distributor network covering dozens of additional countries.

As a global market leader with numerous subsidiaries and distributors, Miltenyi Biotec is
committed to providing our customers around the world with the highest quality products.
In addition to direct selling in more than 20 countries in North America, Europe and
Asia/Pacific, Miltenyi Biotec also provides support for our customers through an
extensive distributor network covering dozens of additional countries.

Basic principle of MACS® MicroBead Technology

Flexible and gentle cell isolation with MACS MicroBeads

Benefit from our column-based cell isolation technology using nano-sized beads for positive cell selection or cell depletion of virtually any cell type from any cell source.

Minimal labeling

Flexible and gentle cell isolation methodMACS Column-based technology owes its longstanding success to the combination of superparamagnetic nano-sized beads and a very high magnetic gradient in our MACS Columns. This combination allows for minimal labeling of target cells and therefore preservation of cell integrity and characteristics. MACS MicroBeads are biodegradable and compatible with all downstream applications, including cell sorting, flow analysis, cell culture, functional assays and molecular analysis.

Minimal labeling preserves cellular integrity and characteristics.

Human PBMCs were labeled with MACS MicroBeads for the isolation of monocytes with a MACS Column (A) or with other nano-sized beads for column-free isolation of the same cell type (B). Scanning electron microscopy showed no visible labeling on cells or alteration of the cells‘ appearance when the cells were isolated with MACS MicroBeads. In contrast, cells isolated column-free with other nano-sized beads showed massive labeling (indicated by arrows) and an altered visual appearance.

No epitope blocking or cell activation

Positive selection with MACS Technology minimizes unwanted effects on target cellsThe high magnetic gradient generated by the matrix in the MACS Column allows for minimal labeling of target cells with nano-sized MicroBeads. This ensures that plenty of surface epitopes remain free for subsequent fluorescent staining and flow cytometry analysis.

MACS Technology minimizes epitope blocking and cell activation.

CD138+ cells were isolated from 4 mL of whole blood with CD138 Whole Blood MicroBeads and a MACS Column (upper right) or other nano-sized beads and a column-free method (lower right) according to the manufacturers’ instructions. The original whole blood sample (left) and isolated cells (right) were stained for CD45, CD19, and CD138 and analyzed by flow cytometry. Only the cells isolated with MACS MicroBeads could be analyzed reliably for CD138.