An actress and former model, Rene Russo is famous for her appearance in a string of popular movies during the 1990's. These include In the Line of Fire, Outbreak, Ransom, Lethal Weapon 3 and The Thomas Crown Affair. She attained a certain degree of cult status for her performance in Freejack, alongside of Emilio Estevez, Mick Jagger, and Anthony Hopkins.

Rene made her film debut in the 1989 picture Major League, acting as the girlfriend of Tom Berenger's character. Her breakthrough role is generally considered to be her part as internal affairs detective Lorna Cole in Lethal Weapon 3 (and again in Lethal Weapon 4) opposite Mel Gibson.

In 2011, after six years away from acting, Rene Russo signed on for the superhero film Thor. She plays the character of Frigga, the mother of the titular hero.