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The arcana domain, or magic domain as it was sometimes called, (not to be confused with the spell domain) was a deity domain that granted divine spellcasters like clerics with prayers connected to the power of the arcane. They may, as part of their training, gained the ability to use wizardlyimplements such as scrolls, wands, and rods.

After the Spellplague, Corellon, Selûne, and Sseth connected themselves to the governance of the arcane, splitting the domain between themselves. None of the three possess the same degree of control over magic that Mystryl, Mystra, or Midnight did, but their influence was far from negligible and each has a unique approach that defines, to an extent, their worshipers' connection to the arcane. Corellon, who supports the efforts of Elven high mages, favors the use of arcane magic in the creation of beautiful art and his eladrin followers approach magic through an almost aesthetic frame of mind. Conversely, Selûne and her worshipers prefer magic that changes with the ebb and flow of the world, with many of their spells or prayers overlapping to some degree with the enchantment school or moon domain. Sseth, the sole evil god of the three, was a secretive deity who fosters illusion, secrecy, and darkness. Worshipers of Sseth, along with the deity himself, often fuel their magic with the pain and suffering of others, drawing on others' life force.