Anti-Quadruplex DNA [4E11]

Clone Number: 4E11Description: Recombinant monoclonal antibody to Quadruplex DNA. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma 4E11. Alternative Name(s) of Target: G4 DNA Immunogen: Oxy-2 or d(TTTTGGGG)2.Specificity: The antibody binds to quadruplex DNA with a Kd of 2.64 nM. Binds specifically to only one type of quadruplex DNA, Oxy-2 (d(TTTTGGGG)2).Application Notes: This antibody binds to quadruplex DNA, which is generated through the association of four guanines bound through Hoogsteen base pairing. G4-forming sequences are associated with immunoglobulin switch regions, promoter sequences, rDNA and telomeric repeats.Antibody First Published in: Henderson et al. Detection of G-quadruplex DNA in mammalian cells. Nucleid Acids 2014; 42(2):860-869 PMID:24163102Note on publication: Describes the generation of several G4-DNA-specific monoclonal antibodies and how these can be used for nuclear staining. Reviews: No reviews available for this antibody yet. Be the first to submit a review at pAbmAbs and enter into their monthly prize draw.