A series of waterborne polyurethane acrylatehybrid(PUA)emulsion was synthesized by seed-emulsion polymerization method from isophoronediisocyanate,polyester diol,dimethylolpropionic acid, and acrylate.The structures and properties of the emulsion were characterized by thermogravimetry(TG),Fourier transform infrared spectroscopy(FT-IR)and transmission electron microscopy(TEM).The influence of the mass fractions of polyacrylate(PA)on the PUA emulsion performance as well as the performance for the medicine packaging material with the basis of aluminum foil were investigated.Results showed that the PUA hybrid emulsion with core-shell structure of PU/PA core-shell was synthesized.PUA had better water resistance and emulsion film properties compared with waterborne polyurethane(WPU).When the mass fractions of PA was 30%,T-peelstrengths of the medicine packaging material reached 15.1 N(25 mm).The index of oxidizable substance,and organic solvent residues were in accordance with the standard of medicine packaging container.It was showed that the waterborne polyurethane adhesive was suitable for medicine packaging.