Michael R RickelsDivision of Endocrinology, Diabetes and Metabolism, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PennsylvaniaAm J Physiol Endocrinol Metab 306:E1217-24. 2014

Improvement in β-cell secretory capacity after human islet transplantation according to the CIT07 protocol

Michael R RickelsDivision of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USADiabetes 62:2890-7. 2013

Michael R RickelsDivision of Endocrinology, Diabetes and Metabolism, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PennsylvaniaAm J Physiol Endocrinol Metab 306:E1217-24. 2014

..That the minimal model SIC is highly correlated to the clamp-derived measures indicates that the FSIGT is an appropriate methodology for the determination of insulin sensitivity in T1D and following islet transplantation. ..

Improvement in β-cell secretory capacity after human islet transplantation according to the CIT07 protocol

Michael R RickelsDivision of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USADiabetes 62:2890-7. 2013

..Islet transplantation results in impaired insulin secretion, but whether defects in insulin sensitivity contribute to impaired glucose disposal after islet transplantation under modern immunosuppression is not known...

..01). These results suggest that after islet transplantation and in response to insulin-induced hypoglycemia, endogenous insulin secretion is appropriately suppressed and glucagon secretion may be partially restored...

Evidence for allograft rejection in an islet transplant recipient and effect on beta-cell secretory capacity

..02). Also, the measures of beta-cell secretory capacity were highly correlated (n=7, r2=0.98, P<0.0001). These results support the use of AIR(arg) as a surrogate indicator of beta-cell secretory capacity in islet transplantation...

..The objective of this pilot study was to evaluate possible differences in insulin sensitivity, food intake, and cravings between the follicular and luteal phases of the menstrual cycle in women with premenstrual syndrome (PMS)...

Total pancreatectomy with islet autotransplantation: summary of an NIDDK workshop

Melena D BellinDepartments of Pediatrics and Surgery, University of Minnesota Medical School, Minneapolis, MN Department of Medicine, Pritzker School of Medicine, Center for Endoscopic Research and Therapeutics CERT, Chicago, IL Division of Diabetes, Endocrinology, and Metabolism and Division of Digestive Diseases and Nutrition, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA Department of Surgery, Medical University of South Carolina, Charleston, SC Baylor Simmons Transplant Institute, Dallas, TX Department of Surgery, University of Texas Medical Branch, Galveston, TX and Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PAAnn Surg 261:21-9. 2015

..The need for a multicenter patient registry that specifically addresses the complexities of chronic pancreatitis and total pancreatectomy outcomes and postsurgical diabetes outcomes was repeatedly emphasized. ..

Chengyang LiuDivision of Transplantation, Department of Surgery, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania 19104 5160, USAEndocrinology 153:1673-83. 2012

..Because AR(max) provides an estimate of the functional beta-cell mass, these results suggest that a low engrafted beta-cell mass may account for the functional defects observed after islet transplantation...

Effects of metformin and leuprolide acetate on insulin resistance and testosterone levels in nondiabetic postmenopausal women: a randomized, placebo-controlled trial

Effect of exenatide, sitagliptin, or glimepiride on β-cell secretory capacity in early type 2 diabetes

Lalitha GudipatyDivision of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PADiabetes Care 37:2451-8. 2014

..The purpose of this study was to evaluate GLP-1 effects on β-cell secretory capacity, an in vivo measure of functional β-cell mass, early in the course of T2D...

..This review discusses the various bariatric procedures and how they alter the enteroinsular axis. Familiarity with these effects can help physicians decide among the different surgical procedures and avoid postoperative hypoglycemia...

..Chronic inflammation converges in type 2 diabetes and atherosclerosis. Modulation of adipokine signaling by innate immunity in humans is of considerable interest given the role of adipokines in insulin resistance and atherosclerosis...

RS rearrangement frequency as a marker of receptor editing in lupus and type 1 diabetes

..Low RS rearrangement levels are also observed in human subjects with SLE or T1D...

Total pancreatectomy with islet autotransplantation: summary of a National Institute of Diabetes and Digestive and Kidney diseases workshop

Melena D BellinFrom the Departments of Pediatrics and Surgery, University of Minnesota Medical School, Minneapolis, MN The Department of Medicine, Pritzker School of Medicine, Center for Endoscopic Research and Therapeutics, University of Chicago, Chicago, IL The Divisions of Diabetes, Endocrinology and Metabolism and of Digestive Diseases and Nutrition, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD The Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA The Department of Surgery, Medical University of South Carolina, Charleston, SC Baylor Simmons Transplant Institute, Dallas, TX The Department of Surgery, University of Texas Medical Branch, Galveston, TX and the Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PAPancreas 43:1163-71. 2014

..The need for a multicenter patient registry that specifically addresses the complexities of CP and total pancreatectomy outcomes as well as postsurgical diabetes outcomes was repeatedly emphasized. ..

GLP-1 plays a limited role in improved glycemia shortly after Roux-en-Y gastric bypass: a comparison with intensive lifestyle modification

Marion L VetterDepartment of Medicine, Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA Department of Psychiatry, Center for Weight and Eating Disorders, University of Pennsylvania Perelman School of Medicine, Philadelphia, PADiabetes 64:434-46. 2015

..Instead, enhanced hepatic metabolism, independent of GLP-1 receptor activation, may be more important for early postsurgical glycemic improvements. ..

Loss-of-function mutations in ABCA1 and enhanced β-cell secretory capacity in young adults

Michael R RickelsDivision of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PADiabetes 64:193-9. 2015