My research addresses the mechanisms underlying injury and scarring in the kidney and peritoneum, in the contexts of chronic kidney disease and peritoneal dialysis. These are examples of fibro-proliferative disorders, conditions that cause significant disease and suffering, and for which treatment options are very limited. Development and testing of novel therapies is restricted by incomplete knowledge of the biology of their progression, and lack of adequate biomarkers to serve as surrogate endpoints in clinical trials.

I am Director of Wales Kidney Research Unit, a Biomedical Research Unit funded by Health and Care Research Wales to deliver an All-Wales strategy for the study of diagnosis, prevention, treatment and social context of kidney disease. See: http://kidneyresearchunit.wales/en/

I am clinically active as a consultant nephrologist within Cardiff and Vale University Health Board, for whom I am Deputy R and D Director, and Medical Lead for the UHB's Clinical Research Facility.