PRECAUTIONS

Cerebrovascular adverse events

An increased risk of cerebrovascular adverse events has been seen in the dementia population with some atypical antipsychotics. The mechanism for this increased risk is not known. An increased risk cannot be excluded for other antipsychotics or other patient populations. Clozaril should be used with caution in patients with risk factors for stroke.

ADVERSE REACTIONS

Postmarketing Clinical Experience

Central Nervous System: obsessive compulsive symptoms

Metabolic and Nutritional Disorders: new onset diabetes

Respiratory System: pneumonia and lower respiratory tract infection which may be fatal

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