The UT Knoxville Office of Research & Engagement drives the campus research enterprise by providing technical expertise in proposal development, sponsored programs administration and compliance requirements. The office assists with identifying external funding opportunities and administering internal funding programs. It is also responsible for developing and maintaining Coeus, the electronic research administration system.

The Office of Research & Engagement also sponsors the Quest Scholar of the Week. This program weekly honors the work of a faculty member at UT Knoxville who is doing outstanding work regardless of the field. Significant activities include publication of a book or an important article in a prestigious journal, a conference presentation, a show in an art gallery, a research breakthrough, an award, or an appointment in recognition for a body of work.