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Novel Therapeutics for Thrombosis and Hemostasis

Dr. Jeffrey Weitz of McMaster University discusses the utility, efficacy of novel oral anticoagulants (NOACs) in reducing risk for VTE and preventing stroke in AF patients.The relative efficacy and safety of the NOACs in reducing intracranial hemorrhage compared to warfarin is considered. He then discusses new clinical trials with these agents designed around morbidity and mortality endpoints that are expected to lead to new indications for the NOACs. Finally, Dr. Weitz considers new,emerging targets in the coagulation cascade, such as F11 and F12, that are upstream of FXa and are viable targets for development of novel anticoagulants.

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