Transepithelial electrical resistance (TEER)

The TEER (transepithelial electrical resistance) Measurement is used to determine the skin barrier function.

The integrity and stability of the stratum corneum is of crucial importance for the integrity of the skin barrier. In simple terms, one can compare the structure of the skin barrier with a wall. The superimposed skin cells (corneocytes) are held together by the hard skin fats. This composition is an essential prerequisite for a healthy and resistant skin. The individual skin cells are additionally closely linked to each other by so-called "tight junctions", direct cell-cell contacts. They occlude the cell interspaces and form a paracellular barrier (diffusion barrier) that is finely regulated and extremely dynamic. This barrier restricts the free diffusion and thus regulates the transport of water and solutes. The density (tissue-specific) is usually described by transepithelial electrical resistance.