The NFL odds opened up with the Buccaneers as 3.5-point favorites at home against their NFC South rivals, and the line has stayed there. It could move more towards Tampa Bay, who have won three of their last four and QB Jameis Winston led a late comeback in a 23-19 over Atlanta. A run on a third-down-and-19 play highlights Winston's leadership and willingness to do whatever it takes to get his team to the playoffs, and his teammates are following him. Meanwhile, the Saints lost 41-38 to Carolina at home, and they've given up 40 points or more in three of their last four games. QB Drew Brees is doing all he can to pace the offense, which is ninth in points scored and fourth in yards for, but there isn't much you can do when your defense is allowing almost 32 points a game. The Bucs won the first meeting of the season by a score of 26-19 at home in Week 2.

Injuries
The Saints were hit hard with injuries this week as they sent RB Mark Ingram to the injured reserve. On top of that, top wideout Brandin Cooks suffered a concussion in practice and is very likely to miss Sunday's game. CB Delvin Breaux, CB Brian Dixon, DT John Jenkins, T Terron Armstead, TE Michael Hoomanawanui and WR Marques Colston were all not at practice on Wednesday. Breaux is the only one with a known injury as his hamstring is bothering him and he didn't play last week, while Colston usually gets a veteran's day.

For the Buccaneers, LB Kwon Alexander is gone for the next four games because of a drug suspension. DE Jacquies Smith has a hamstring injury and is working to get back into the lineup for Sunday's huge game.

Trends
The Saints are 5-6-1 ATS this season, going 2-4 ATS on the road, while the Bucs are 7-5 ATS overeall and 3-3 ATS at home. The total comes in at 51, and the Buccaneers have gone over six times. The Saints have gone over seven times, along with a push.

The Bucs are 3-7 SU (their Week 2 win snapped a seven-game skid) and 6-4 ATS in their last 10 meetings with the Saints. New Orleans are 6-4 SU and 5-5 ATS in their last 10 in Tampa Bay.