Draba weberi is an apomictic species allied to D. exunguiculata, D. grayana, and D. streptobrachia. From those, it is distinguished by having ovate fruits, clawed petals, and sessile, 2-4-rayed trichomes with untwisted rays often appressed to leaf and stem surfaces. Draba weberi is known from near North Star Peak in central Colorado (Summit County).