The 999th episode of WWE Raw was held at the arena on July 16, 2012, the first time the WWE played at Mandalay Bay.

The first National Basketball Association game on the Las Vegas Strip since 1981 was at the Mandalay Bay Events Center on October 6, 2012, a preseason contest between the Denver Nuggets and the Los Angeles Clippers. The teams returned for preseason games in 2013 and 2014. In 2016, it hosted the NCAA Men's basketball postseason tournament Vegas 16. The NBA and WNBA officially announced on October 17, 2017 that the San Antonio Stars would relocate from San Antonio, Texas and would be playing at the Mandalay Bay Events Center starting in the 2018 season as the Las Vegas Aces. They played their first home game on May 27, 2018.[3]