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A team from Ohio State University have created a new cell-culture system related to mechanisms which take effect in those with multiple sclerosis.

This system, which allows two types of cells to interact in the laboratory as they would in nature, will allow scientists to study how myelination is switched on and off.

Chen Gu, lead author, explained: "This channel is important because it is what leads to electrical activity and how neurons communicate with each other downstream.

"If that process is disrupted by demyelination, disease symptoms may occur."

In other news, a Scripps Research Institute study has halted multiple sclerosis in mice through the use of a compound which shuts down white blood cell TH17 which malfunctions in those with the condition.

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Disclaimer: 'MS Views and News' (MSVN), does not endorse any products or services found on this blog. It is up to you to seek advice from your healthcare provider. The intent of this blog is to provide information on various medical conditions, medications, treatments, and procedures for your personal knowledge and to keep you informed of current health-related issues. It is not intended to be complete or exhaustive, nor is it a substitute for the advice of your physician. Should you or your family members have any specific medical problem, seek medical care promptly.

Friday, July 22, 2011

THURSDAY, July 21 (HealthDay News) -- Newer "biologic" drugs for multiple sclerosis do benefit some patients, a new study finds, but they are extraordinarily expensive and may not be cost-effective when compared to more basic treatments.

That's not to say that people with MS should not be taking these so-called disease-modifying therapies (DMTs) -- such as interferon or Tysabri. Rather, moves should be made to make the drugs more affordable, the researchers said.

Although these drugs aren't a cure, "they delay disease progression [and are] the best we can do at this point," explained Katia Noyes, lead author of a paper appearing in the July 20 online issue of Neurology. And right now, she noted, "these medications are available in European countries for about one-third of the cost as in the U.S."

The authors noted, for example, that in 2010 a year's supply of one type of interferon drug would cost an estimated $12,000 in the United Kingdom, compared to $34,000 in the United States.

Lowering U.S. prices by two-thirds (67 percent) would make the drugs much more cost-effective, the authors stated. So would starting the medications earlier, so as to better stave off MS-linked disability.

"This in no way suggests that anyone appropriate for treatment should not be on it, [but] the study reminds us that costs of the therapies, particularly the out-of-pocket costs for people with MS, are an important consideration," said Nicholas LaRocca, vice president for health care delivery and policy research at the National Multiple Sclerosis Society (NMSS) in New York City.

The NMSS was one of the study's sponsors.

The drugs can typically cost about $30,000 a year, said Noyes, who is associate professor and division chief of health policy and outcomes research at the University of Rochester Medical Center.

According to the NMSS, about 400,000 people in the United States have multiple sclerosis, about 85 percent of whom have relapsing-remitting MS, for which DMTs are used.

The authors' model was based on data on 844 people with relapsing-remitting MS in the United States. It took into account not only the cost of DMTs, but also hospital and office-based care, diagnostic tests, nursing home costs and time taken off from work.

According to the investigators' calculations, DMTs represent about half of all health care costs over 10 years for a person with MS.

And overall, the health gains seen from these medications were "modest," the authors stated.

For instance, people taking interferon beta-1b experienced an average of about six years with no relapses over the course of a decade, compared to five years without relapses for those not taking DMTs.

Still, the benefits were highly variable between individuals.

"Everyone with MS is different and although some people derive modest benefit from therapy, others benefit greatly and are able to continue working and living a full and active life because of their therapy," LaRocca said.

And the study didn't look at other aspects of disease progression, such as how severe the relapses were, or the timing, which would also affect quality of life.

"We may be ready to think about some mechanisms of controlling pharmaceutical prices. Most countries have these mechanisms in place," said Noyes. "[Or] maybe there should be a push for developing more effective medications."

An accompanying editorial pointed out that costs may naturally go down with the advent of more oral DMTs (as opposed to the injectables that are primarily in use now) and as drug company patents expire and generics are introduced.

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Disclaimer: 'MS Views and News' (MSVN), does not endorse any products or services found on this blog. It is up to you to seek advice from your healthcare provider. The intent of this blog is to provide information on various medical conditions, medications, treatments, and procedures for your personal knowledge and to keep you informed of current health-related issues. It is not intended to be complete or exhaustive, nor is it a substitute for the advice of your physician. Should you or your family members have any specific medical problem, seek medical care promptly.

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Disclaimer: 'MS Views and News' (MSVN), does not endorse any products or services found on this blog. It is up to you to seek advice from your healthcare provider. The intent of this blog is to provide information on various medical conditions, medications, treatments, and procedures for your personal knowledge and to keep you informed of current health-related issues. It is not intended to be complete or exhaustive, nor is it a substitute for the advice of your physician. Should you or your family members have any specific medical problem, seek medical care promptly.

..All contributions are tax deductible to the fullest extent allowed by law

.===========================================================

Disclaimer: 'MS Views and News' (MSVN), does not endorse any products or services found on this blog. It is up to you to seek advice from your healthcare provider. The intent of this blog is to provide information on various medical conditions, medications, treatments, and procedures for your personal knowledge and to keep you informed of current health-related issues. It is not intended to be complete or exhaustive, nor is it a substitute for the advice of your physician. Should you or your family members have any specific medical problem, seek medical care promptly.

SYMPTOMS of MS

In multiple sclerosis , damage to the myelin in the central nervous system (CNS), and to the nerve fibers themselves, interferes with the transmission of nerve signals between the brain and spinal cord and other parts of the body. This disruption of nerve signals produces the primary symptoms of MS, which vary depending on where the damage has occurred.

Over the course of the disease, some symptoms will come and go, while others may be more lasting.

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