In 2006, Salvador made her film debut as one of the supporting characters in the horror movie Sukob[7] wherein she portrayed the role of a clairvoyant young girl. This earned her several accolades including the Star Award for Movies for New Movie Actress of the Year and the Golden Screen Award for Breakthrough Performance by an Actress, as well as a nomination at the FAMAS Awards for Best Supporting Actress. That same year, she also starred as a social climber teenage girl in the film First Day High[8] and was also critically acclaimed for her portrayal as a teenager suffering from cerebral palsy in the "Regalo" episode of Maalaala Mo Kaya.[9] For the latter, Salvador earned a nomination for Best Single Performance by an Actress at the Star Awards for Television[10] but lost to co-star Vilma Santos, who played as her mother in the said episode.[11]

Salvador, in 2011, was cast as one of the main characters in the critically acclaimed family-military drama series Minsan Lang Kita Iibigin.[19] That same year, she also co-produced the independent film Thelma,[20] with which she also starred in the title role. Her performance in the film was praised by Philippine Entertainment Portal's Bong Godinez, stating in his review that Salvador gives an "impressive performance" and that she "brandished her depth as an actress without going overboard".[21] He also added that she "[dishes] out the emotions in an understated manner". However, Tessa Guazon of the Young Critics Circle - Film Desk criticized Salvador's performance by saying that there are failures in "conflict and depth".[22] Furthermore, she mentioned that Salvador was out of track in the movie and that she "missed [the] subtle leap". Despite mixed reviews on the film, Salvador went on and bagged the Gawad Urian Award for Best Actress as well as the Film Academy of the Philippines Award for Best Actress.[3][4]

As of 2014, Salvador starred as Nicole Esquivel in the highly controversial teleserye, The Legal Wife, alongside Angel Locsin, Jericho Rosales, and JC De Vera. After The Legal Wife, Salvador is set to do another teleserye, confirmed by ABS-CBN and Salvador herself.

On December 2013, it was announced that Salvador had signed a recording contract with Ivory Music & Video. While recording the album, Salvador worked with award-winning arranger and producer, Jonathan Ong. By March 2014, she revealed through her Instagram account that the title will be Believe along with its track listing which contains mainly original composition and two cover songs.[26] The carrier single, "Dahan-Dahan", was released on March 6 while the album was released nationwide on March 25. The album also features collaborations with rapper Abra and Project Pinas. Salvador also co-wrote a song titled "Buong Gabi".[27] She released her firsl single from the said album titled "Dahan Dahan".

On June 8, 2014, the album was eventually certified gold for selling over 7,500 copies nationwide and Salvador appeared on ASAP to receive a Gold Record award. She also staged her first major sold out concert entitled "MAJ: The Legal Performer" on July 12 at the Music Museum.[28]

In September 14, 2014 she released her second single called "Halikan Na" featuring Abra. The same month the music reached at no. 7 in the top 10 Philippine pop music.

In 2013 Salvador joined the PETA campaign to Free Mali from captivity in Manila zoo and have her transferred to Boon Lott's Elephant Sanctuary where she can be given proper treatment and care. Mali is the only captive elephant in the Philippines and the zoo does not have adequate knowledge or resources to properly care for her. [29]