Full Title

Purpose

This phase I study will evaluate the safety and effectiveness of different doses of a patient’s own immune cells (T cells) which have been changed to help recognize and destroy his prostate cancer cells by targeting a protein called prostate-specific membrane antigen. The T cells are removed from the patient’s blood, modified with a gene in the laboratory so they are better able to recognize and kill prostate cancer cells, and then returned to the patient’s body. This gene is inserted into the T cells using a weakened virus. /

It is hoped that this approach will help each patient’s own T cells recognize his prostate cancer cells and possibly kill them.

Eligibility

To be eligible for this study, patients must meet several criteria, including but not limited to the following:

Patients must have metastatic prostate cancer that has not yet been treated with chemotherapy. Patients may have had hormonal therapy.

Patients must have rising PSA levels and a serum testosterone level under 50 ng/mL.