Atypical Hyperplasias

In this section three lesions are discussed:

Atypical Ductal Hyperplasia (ADH)

Columnar Cell Change with atypia

Atypical Lobular Hyperplasia (ALH)

All three conditions if identified in a core biopsy require at least follow up and usually a diagnostic excision biopsy and all three lesions
confer up to a four or five times increased risk of the long term development of cancer.

ADH (example 2)
The following sequence of four images show different views of a small focus of ADH. Note partial involvement of the duct, particularly in the top image, a monotonous population of epithelial cells showing
rigid structure across ducts and low grade cytology. Luminal microcalcifications are present.

ADH (example 3)
Further example of ADH. This focus was adjacent to a mucocele-like lesion. There is a known association between the two condidtions.