Necrosis of pancreatic tissue affecting acinar and ductal tissues as well as the islets of Langerhans; vascular damage causes hemorrhage into the parenchyma.Macroscopically, the pancreas exhibits red-black hemorrhage interspersed with foci of yellow-white, chalky fat necrosis.

Solitary, 2-30 cm lesions of the pancreas, formed by walling-off of areas with hemorrhagic fat necrosis.Composed of necrotic debris encased by fibrous walls of granulation tissue, and lacks epithelial lining.

This condition is characterized by parenchymal fibrosis, reduced number and size of acini with relative sparing of the islets of Langerhans, and variable dilation of the pancreatic ducts.

Chronic Pancreatitis(TOPNOTCH)

22

What is the most constant morphological feature of Chronic Pancreatitis?

Acinar Loss(TOPNOTCH)

23

60% of cancers of the pancreas arise in what area?

Head > Body > Tail(TOPNOTCH)

24

What is the most frequently altered oncogene in pancreatic cancer?

K-RAS (TOPNOTCH)

25

What is the most frequently inactivated tumor suppressor gene in pancreatic cancer?

p16(TOPNOTCH)

26

What is the strongest environmental risk factor for developing Pancreatic Cancer?

Smoking(TOPNOTCH)

27

What are the two characteristic features of Pancreatic Cancer?

Highly invasive and it elicits an intense non neoplastic host reaction called a desmoplastic response(TOPNOTCH)

28

Where do Pancreatic cancers usually metastasize?

Lungs and bones(TOPNOTCH)

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This variant of Pancreatic cancer is characterized by formation of zymogen granules and the production of exocrine enzymes including trypsin and lipase`

Acinar cell carcinoma(TOPNOTCH)

30

What is the first symptom of pancreatic cancer?

Pain(TOPNOTCH)

31

These structures are formed by the walling off of areas of peripancreatic hemorrhagic fat necrosis with fibrous tissue and are usually composed of central necrotic hemorrhagic material rich in pancreatic enzymes surrounded by non epithelial lined fbrous walls of granulation tissue

Pseudocyts(TOPNOTCH)

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These kinds of cyst account for 75% of cysts seen in the pancreas

pseudocyts(TOPNOTCH)

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Gross morphology: extensive parenchymal necrosis accompanied by diffuse hemorrhage within the substance of the gland