MEXICO CITY—Thousands of protesters took to Mexico City’s central thoroughfare Sunday to protest U.S. President
Donald Trump
and his plans to build a 2,000-mile border wall, while also blasting Mexican President
Enrique Peña Nieto
and the ruling PRI party.

Marchers carried signs criticizing both the U.S. and Mexican leaders along the capital city’s Paseo de La Reforma boulevard to the Angel of Independence monument.

Mexico City’s police department said there were no injuries or incidents at the demonstration. Police estimated the crowd at 20,000 people, with 3,000 police officers on hand to keep order.

Protesters from Vibra Mexico, a coalition of nonprofits, media outlets and university groups that organized anti-Trump protests Sunday in 19 cities across the country, erected a wall made of cardboard blocks at the foot of the monument spray-painted with the words “Xenophobia,” “Discrimination,” “Exclusion” and “Racism.”

While some marchers carried effigies of the U.S. president and chanted anti-Trump slogans, equal numbers of protesters called for Mr. Peña Nieto to resign and held signs denouncing what they described as corruption in Mexico’s government.

“This march is about removing Peña,” said Mauricio Hernández, a 55-year-old waiter and Mexico City resident. “The people who are yelling about Trump are just a distraction…There’s no leadership in this country.”

Also unpopular in Mexico is Mr. Trump, who has riled Mexicans with his plans to expel illegal immigrants from the U.S., renegotiate the North American Free Trade Agreement under better terms for the U.S., and his assertions that he can make Mexico pay for the border wall.

“I’m here because I’m Mexican and I’m angry because of Trump’s threats and insults,” said Nelia Someillan, a 65-year-old teacher from Mexico City. “And why is Trump able to threaten and insult us? Because our government is a total pushover.”

Yolanda Castillo, a 48-year-old insurance agent from Mexico City, carried a sign criticizing all of Mexico’s major political parties as well as Mr. Trump, and said Mexico is vulnerable to attacks from the U.S. president because of its weak leadership.

“If our economy were stronger, we wouldn’t have any problems with our neighbors,” she said.

Write to Robbie Whelan at robbie.whelan@wsj.com<mailto:robbie.whelan@wsj.com>