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Figure 5

(A) Representative FACS plots of IFN-γ production in indicated cell subsets isolated from pancreatic islets of NOD mice treated with control mAb or ChMBC7 from 3–10 weeks of age (n = 7 in each group). (B and C) The percentages (B) and total numbers (C) of IFN-γ+ cells in indicated cell subsets prepared as in A. (D) The expression of T-bet in in vitro activated CD4+ and CD8+ T cells (by anti-CD3/CD28 and IL-2) with or without ChMBC7. Data are representative of 3 (A–C) or 2 (D) independent experiments. Statistical data are mean ± SEM. P values are calculated using Student’s t test. **P < 0.01; ***P < 0.001.