A sign of things to come? Khloe Kardashian gave what may be the most telling hint yet that her marriage to Lamar Odom is in trouble when she changed her display name on Twitter from Khloe Kardashian Odom to just Khloe. (Her username, @KhloeKardashian, remains the same.)

Whether the change in name coincides with a change of heart remains to be seen, but it does coincide with something else: the estranged couple's fourth wedding anniversary. The 29-year-old reality star and the 33-year-old athlete married exactly four years ago today, Sept. 27.

Odom, for his part, has denied that he and his wife are on the outs. He even defended her and her family on Twitter this week, after his father, Joe Odom, told Radar Online that his son needed a "clean break" from the Kardashians.

"That man wasn't even invited to my wedding," the NBA player wrote. "He has never met my mother in law and some of my other family. How can a man who has NOT once called me to check on my well being have the nerve to talk so recklessly about his own 'son.' He is my downfall!"

Then, referring to his in-laws, he added: "He disrespecting the ONLY FAMILY that has loved me without expecting anything in return. They are the ONLY ones that have been here consistently 4 me during this dark time. Only person 2 blame is myself."

Kardashian, meanwhile, has yet to comment directly on her problems with the athlete but has been sharing cryptic messages on both Twitter and Instagram for weeks now.

Earlier this month, she posted a selfie captioned "see no evil, hear no evil, speak no evil." And one day later, she reposted a telling quote from actress Lauren London. "Sometimes you just gotta be your own hero and save your own little heart," the text read. "Because sometimes, the people you can't imagine living without, can actually live without you."