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Lung Cancer Metastasis

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This image shows how lung cancer cells invade surrounding tissues and start to spread (metastasis). These lung cancer cells have a mutation of a gene called LKB1 (in green) that promotes invasion. Actin, a cytoskeletal protein, is in red, and the cell nucleus is blue. These H157 lung cancer cells are expressing a GFP-tagged piece of LKB1 to disrupt its normal function. Spheroids of these cells were embedded in a 3-D collagen matrix with cells invading for 24 hours.

This image was originally submitted as part of the 2016 NCI Cancer Close Up project.