WILMINGTON, MA — Below are the most-viewed stories involving local business on Wilmington Apple in 2018:BREAKING NEWS: Here Is What’s Going In At The Old Sonic Location…CONFIRMED: Casa Blanca Mexican Restaurant To Open In Wilmington At Former Chili’s LocationWHOA! Apartment Complex, 7 Retail Stores & Bank Proposed At Woburn St. & Lowell St. IntersectionNew Restaurant To Open On Concord Street This SpringSpruce Farm Condo Development Set To Add 27 55-And-Over Housing Units In WilmingtonTremezzo Owners Look To Open Italian Bakery In WilmingtonElia’s Country Store To Be Closed For Approximately One WeekKitty’s In North Reading Closed Until Further Notice After Salmonella OutbreakNew Retail/Restaurant Development, Pedestrian Improvements Coming To Ballardvale StreetCondos & Townhouses Proposed For Corner Of Main Street & Butters RowBREAKING NEWS: Rite Aid/Walgreens To Close In WilmingtonWORTH THE WAIT: Pancho’s Cantina, New Mexican Restaurant, Opens In Wilmington Near TargetPHOTO & VIDEO: Lucci’s Italian Sub Named ‘Best Italian Sub In Massachusetts’Pacific Grove Has A New Owner, Promises Not To Make Any Changes(EDITOR’S NOTE: Each of the above stories received at least 1,500 hits in 2018.)Like Wilmington Apple on Facebook. Follow Wilmington Apple on Twitter. Follow Wilmington Apple on Instagram. Subscribe to Wilmington Apple’s daily email newsletter HERE. Got a comment, question, photo, press release, or news tip? Email wilmingtonapple@gmail.com.Share this:TwitterFacebookLike this:Like Loading… RelatedWilmington’s Top Political & Government Stories Of 2018In “Government”NEW RESTAURANT ALERT: Habit Burger Grill To Open Its First New England Location Right Here In WilmingtonIn “Business”BOARD OF HEALTH: Tremezzo Pizzeria & Michael’s Place Opening Soon; Silence From Casa Blancaread more

The Welch FoundationDr. Jeffrey Rimer at work in the lab at the University of Houston.In the last 30 years, not much has changed in terms of drug treatment for kidney stones. But that could be about to change.University of Houston researcher Dr. Jeffrey Rimer and his colleagues have identified a substance that could potentially reduce kidney stone growth by 90 percent. And they’ve found some potential new molecules that could dissolve stones — or prevent them from forming altogether.The Welch FoundationDr. Jeffrey Rimer (left) works in the lab at the University of Houston.Kidney stones form when the body has trouble clearing crystal-forming substances from the kidneys, such as calcium oxalate or uric acid. Or sometimes substances that prevent crystals from sticking together are absent from the urine. Either way, once crystals form and grow larger, they can become painful obstructions of urine flow.Now, Rimer and his partners have found that the compound hydroxycitrate significantly impedes stones from growing. Hydroxycitrate is a natural component of the fruit garcinia cambogia (also known as the Malabar tamarind). If that name sounds familiar, that’s because it’s already being sold as a supplement that’s gotten a lot of press for possible weight loss benefits.Such supplements are not studied and approved by the FDA, but, because garcinia cambogia is already on shelves, that means Rimer’s partners at NYU have already been able to start some clinical trials involving it. Once ingested, they wanted to find out whether hydroxycitrate would make it to the kidneys intact. So far, the studies have shown it does.The Welch FoundationDr. Jeffrey Rimer (right) works in the lab at the University of Houston.Dr. Rimer is quick to point out that it’s still far too early for anyone to run out and start taking garcinia cambogia to prevent kidney stone growth. More clinical studies are needed to determine what the best dosage would be, potential side effects, and other factors.When it comes to developing a drug that could treat existing kidney stones — or prevent them from forming in the first place — Rimer and his associates have come across some molecules that could potentially dissolve stones or that might inhibit nucleation, which is the very first step of a crystal forming.For his work, Rimer was recently awarded The Welch Foundation’s Norman Hackerman Award in Chemical Research. Shareread more

Gerry Broome/APRick Colyer votes at the Durham County Library North Regional in Durham, N.C., Tuesday. Braun’s win might mean more for how Republicans try to win in primaries the rest of this year than Blankenship’s loss.4. Democrats aren’t facing primary headwinds yet — and might not.While there have been signs of division on the Democratic side, it hasn’t manifested very strongly.Instead, the division so far has still mostly been on one side — with Republicans unhappy with Washington. There were opportunities Tuesday night for the more progressive wing of the party to flex its muscles, but it instead chose the pragmatic route.Think: the Ohio governor’s race primary, for example, where former Rep. Dennis Kucinich was trying to paint Richard Cordray, the former head of the Consumer Financial Protection Bureau appointed by Obama, as too much of a centrist with less progressive views on guns. But Cordray, who was endorsed by Massachusetts Sen. Elizabeth Warren, trounced Kucinich by 40 points.It might be somewhat worrying for Democrats that more Republicans turned out for the open Ohio gubernatorial primary than one that got as much attention as the Cordray-Kucinich contest. And a relatively unknown progressive challenger to Manchin got 30 percent of the vote Tuesday night, which is similar to what happened in Texas two months ago when an unknown got almost a quarter of the vote against Beto O’Rourke. But those seem relatively minor, compared with the anti-Washington messages Republicans are winning with and an ousted congressman.Looking ahead over the next month, in more than a dozen states, there’s really only one Senate race where progressives are expected to mount a significant challenge to a sitting Democrat. That’s Dianne Feinstein facing off with state Sen. Kevin de León. He’s a darling of the left, but Feinstein’s team is confident, and polls have shown her with a comfortable lead so far. There’s also the May 22 runoff for the 7th Congressional District in Texas, featuring Lizzie Pannill Fletcher against Laura Moser.The Democratic Congressional Campaign Committee tried to muscle Moser out of the race, because it felt she was too liberal for the district. It’s a key race, because Hillary Clinton got more votes than Trump in the district yet it is represented by a Republican, Rep. John Culberson.But that’s it. The lack of challenges to Democrats, especially senators, means they’re able to preserve their resources to fight in the general election. The real Democratic fight that’s coming is likely in 2020 with a crowded presidential primary field and a race to the left shaping up.But, right now, there’s nothing more unifying for Democrats than Trump.Copyright 2018 NPR. To see more, visit http://www.npr.org/. Share In Indiana, Mike Braun, who runs a warehousing and shipping company, won the GOP Senate primary. He will take on another top GOP Senate target in a state Trump won — Joe Donnelly. Braun did it with a conservative outsider businessman message (heard that one before?), defeating two Republican congressmen. He ran a brutal ad that painted Reps. Todd Rokita and Luke Messer as cardboard cutouts indistinguishable from each other. Midterms, especially primaries, are won and lost by activists.And right now, if Tuesday night’s primary results are any indication, Democrats appear to be in better shape structurally than the GOP. It’s still very early in primary season to draw conclusions that are too sweeping, but here are four takeaways based on what’s known from Tuesday night’s elections in Ohio, Indiana, West Virginia and North Carolina:1. Republicans dodge a bullet. Are they learning the lesson of Alabama?Washington Republicans were holding their breath, hoping that Don Blankenship would not win the Republican Senate primary in West Virginia. Blankenship served a year in prison after 29 people were killed when one of his mines exploded and he was convicted of conspiring to undermine mine-safety regulations. Washington Republicans believed that if he won, he would lose to Democratic incumbent Sen. Joe Manchin. And Manchin should be a top GOP target in a state Trump won by one of the widest margins of any state in the country in the 2016 presidential election.Blankenship had been showing remarkable and surprising strength in the race with an anti-Washington message. He went after Republican Senate Leader Mitch McConnell and said he was “Trumpier than Trump” after Trump tweeted urging West Virginia Republicans not to vote for him. Despite internal polling released by his opponents’ campaigns showing Blankenship in the lead, he wound up finishing third. State Attorney General Patrick Morrisey won with a little more than a third of the vote.Pragmatic Republicans are exhaling Wednesday morning and hoping that the base of the party is heeding Trump’s call to “Remember Alabama” and learning that nominating fatally flawed candidates who would have trouble winning in a general election is a bad idea.Republicans over the past decade have lost roughly half a dozen Senate seats because of problematic candidates. That’s something McConnell and his team have been throwing their hands up about for years.McConnell’s team was loving this West Virginia result, though.Thanks for playing, @DonBlankenship. #WVSen pic.twitter.com/TV1ETgQdmu— Team Mitch (@Team_Mitch) May 9, 20182. McConnell isn’t entirely off the hook. Despite his team’s gloating, the Republican Senate leader has become problematic for the party in some circles.He remains the most unpopular senator in the country. And just 30 percent of even people in his home state of Kentucky approve of the job he is doing.Highlighting that point, in congratulating Morrisey, Senate Conservatives Fund President Ken Cuccinelli wrote of McConnell:“It’s important to note that Senator Mitch McConnell put this seat at greater risk by giving an unattractive candidate like Don Blankenship an even more unpopular foil to run against. McConnell has become so toxic with Republican primary voters that his support is often the kiss of death and his opposition is a powerful endorsement.”3. Republican voters continue to reject Washington.To that point, there was ample evidence Tuesday night that there is quite a bit of angst in the GOP base toward Washington Republicans:In North Carolina, the first sitting congressional representative this year lost a primary challenge — Rep. Robert Pittenger in North Carolina’s 9th Congressional District. Mark Harris, who lost to Pittenger in 2016 by 2 points, won in a rematch this time around. This seat, which leans Republican — Trump and Romney won it by 12 points — could now be competitive. The Democrat in the race, Dan McCready, had raised more money than Pittenger and has far more cash on hand than Harris, $1.2 million versus $71,000. As the Charlotte Observer notes, McCready is “one of nine Democratic challengers with a six-figure fundraising advantage over a GOP incumbent, according to the Center for Responsive Politics. Only one Democratic challenger in the country had more cash on hand at the end of the 1st quarter.” And Democrats also showed up in droves in Tuesday’s primary, far outpacing the GOP turnout.In West Virginia, Rep. Evan Jenkins, who was the early favorite in the race and looks the Washington congressman part, finished second. Instead, the winner was the state attorney general, Patrick Morrisey, who ran as an “outsider” (despite his lobbyist past) and gained attention for an ad that uprooted a West Virginia mountain and dropped it on the U.S. Capitol. I’m running for U.S. Senate not to just change Washington, but to blow it up and reinvent it. Washington is fundamentally broken. We can fix that with a West Virginia conservative fighter! #wvsen pic.twitter.com/hogbOoYnms— AG Patrick Morrisey (@MorriseyWV) April 5, 2018read more