Rabbit Sphingosine Kinase 1 (SPHK1) interaction partners

Melatonin administration significantly inhibited those changes and induced a decreased immunoreactivity for rabbit hemorrhagic disease virus VP60 antigen in the liver. Results obtained indicate that the SphK1/S1P (show MBTPS1 Proteins) system activates in parallel to viral replication and the inflammatory process induced by the virus.

Human Sphingosine Kinase 1 (SPHK1) interaction partners

siRNA-mediated knockdown of Sphk2 (show SPHK2 Proteins) but not SphK1 resulted in a reduction of cargo content in purified exosomes

These findings suggested that miR125b may regulate Alzheimer's disease (AD), and neuronal cell growth and apoptosis, via the regulation of inflammatory factors and oxidative stress by SphK1; therefore, miR125b may be involved in the development of AD.

these findings suggest that SphK1 may play a pivotal role in HER2 (show ERBB2 Proteins)-positive breast carcinogenesis

Immunohistochemistry of xenograft tumors showed significant enhancement of caspase-3 (show CASP3 Proteins) cleavage and suppression of Ki67 (show MKI67 Proteins) and phospho-EGFR (show EGFR Proteins) by the drug combination, but SphK1 downregulation occurred only in MDA-MB-468 tumors, so is unlikely to be integral to treatment efficacy

SphK1 expression regulates the early stage of colon carcinogenesis and tumor growth, thus inhibition of SphK1 may be an effective strategy for colon cancer chemoprevention.

the blockage of SPHK1 activity to attenuate autophagy may be a promising strategy for the prevention and treatment of patocellular carcinoma

Mouse (Murine) Sphingosine Kinase 1 (SPHK1) interaction partners

vascular transcriptome analysis shows that S1P (show S1PR1 Proteins) pathway is critical in the regulation of vascular function in AngII-induced hypertension, although Sphk1 may have opposing roles in the regulation of vasoconstriction and endothelium-dependent vasorelaxation.

these findings suggest that SphK1 may play a pivotal role in HER2 (show ERBB2 Proteins)-positive breast carcinogenesis

SphK1 is involved in maladaptive hypertrophy and we propose that heart failure might be an additional direct target for therapeutic intervention with SphK1 inhibitors.

These results suggest that SphK1 expression plays a pivotal role in the early stages of colon carcinogenesis

the recruitment of Sphk1 to sphingosine-enriched endocytic vesicles and the generation of sphingosine-1-phosphate facilitate membrane trafficking along the endosomal pathway.

SK1 activation is renoprotective via induction of autophagy in the fibrotic process

donor islets from mice deficient in Sphk1 KO contain a reduced number of resident intraislet vascular endothelial cells. The main product of Sphk1, sphingosine-1-phosphate, controls the migration of intraislet endothelial cells in vitro. In vivo, Sphk1 knockout islets have an impaired ability to cure diabetes compared with wild-type controls.

Sphingosine Kinase 1 (SPHK1) Protein Profile

Protein Summary

The protein encoded by this gene catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P), a lipid mediator with both intra- and extracellular functions. Intracellularly, S1P regulates proliferation and survival, and extracellularly, it is a ligand for cell surface G protein-coupled receptors. This protein, and its product S1P, play a key role in TNF-alpha signaling and the NF-kappa-B activation pathway important in inflammatory, antiapoptotic, and immune processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.