Green Leafy Vegetables May Prevent Fatty Liver

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A larger portion of green leafy vegetables in the diet may reduce the risk of developing liver steatosis, or fatty liver. In a study published in PNAS researchers from Karolinska Institutet in Sweden show how a larger intake of inorganic nitrate, which occurs naturally in many types of vegetables, reduces accumulation of fat in the liver. There is currently no approved treatment for the disease, which can deteriorate into life-threatening conditions such as cirrhosis and liver cancer.

“When we supplemented with dietary nitrate to mice fed with a high-fat and sugar Western diet, we noticed a significantly lower proportion of fat in the liver,” says Mattias Carlström, Associate Professor at the Department of Physiology and Pharmacology, Karolinska Institutet.

Their results were confirmed by using two different cell culture studies in human liver cells. Apart from a lower risk of steatosis, the researchers also observed reduction of blood pressure and improved insulin/glucose homeostasis in mice with type 2 diabetes.

The research group’s focus is the prevention of cardiovascular diseases and type 2 diabetes through dietary changes and by other means. Previous studies have shown that dietary nitrate from vegetables enhances the efficiency of the mitochondria, the cell’s power-plant, which can improve physical endurance. It has also been shown that a higher intake of fruit and vegetables has a beneficial effect on cardiovascular function and on diabetes.

“We think that these diseases are connected by similar mechanisms, where oxidative stress causes compromised nitric oxide signaling, which has a detrimental impact on cardiometabolic functions,” says Dr. Carlström. “We now demonstrate an alternative way to produce nitric oxide, where more nitrate in our diet can be converted to nitric oxide and other bioactive nitrogen species in our body.”

Even though many clinical studies have been done, there is still considerable debate about what properties of vegetable make them healthy.

“It doesn’t take huge amounts to obtain the protective effects we have observed—only about 200 grams per day,” says Dr. Carlström.” Unfortunately, however, many people choose not to eat enough vegetables these days.”

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Elaine Ferguson, MD is a pioneer in the field of integrative and holistic medicine. She’s a graduate of Brown University, Duke University School of Medicine and completed her post-graduate training at the University of Chicago. During her trailblazing career she served as the founding medical director of the nation’s first Independent Practice Association (IPA) of chiropractors to provide primary care in a managed care setting, and practiced at the Cancer Treatment Centers of America. Also, Dr. Ferguson taught mind-body medicine at one of the nation’s first graduate level holistic medicine programs. She is the host of the acclaimed PBS pledge special SuperHealing Secrets currently airing nationwide, and has written several books, including the international bestseller SuperHealing: Engaging Your Mind, Body, and Spirit to Create Optimal Health and Well-Being. As a wellness consultant, and speaker, she’s lectured extensively at conferences, universities and medical schools, consulted with businesses, government agencies, not-for-profits, faith based organizations, and testified on a Congressional alternative medicine panel.

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