Adenosine Deaminase, RNA-Specific, B1 (ADARB1) ELISA Kits

ADARB1 encodes the enzyme responsible for pre-mRNA editing of the glutamate receptor subunit B by site-specific deamination of adenosines. Additionally we are shipping RED1 Antibodies (35) and RED1 Proteins (7) and many more products for this protein.

After fear conditioning protocol, mRNA expression of ADAR2 increased in amygdala and hippocampus, and those mice had a learning-dependent increase in the alternatively spliced inactive form of ADAR2 in the amygdala.

ADAR2 is a key factor for maintaining edited-miRNA population and balancing the expression of several essential miRNAs involved in cancer.

This study clearly demonstrates that ADAR2 influences miRNA abundance and targeting at several levels in the mouse brain.

Analysis of editing in the filamin A (show FLNA ELISA Kits) encoding mRNA shows very high editing levels outside the nervous system; further shows FLNA (show FLNA ELISA Kits) editing is mainly achieved by ADAR2 but that in some cases ADAR1 (show ADAR ELISA Kits) can efficiently compensate for ADAR2.

RED1 (ADARB1) Antigen Profile

Antigen Summary

This gene encodes the enzyme responsible for pre-mRNA editing of the glutamate receptor subunit B by site-specific deamination of adenosines. Studies in rat found that this enzyme acted on its own pre-mRNA molecules to convert an AA dinucleotide to an AI dinucleotide which resulted in a new splice site. Alternative splicing of this gene results in several transcript variants, some of which have been characterized by the presence or absence of an ALU cassette insert and a short or long C-terminal region.