I have several E2E BRIDGE services which use the same SAP instance. So the connection parameters like User/PW, systemNr etc. are the same. Is there a possibility to define the values for this settings globally?

yes this is possible. If you use the notation {{mySettingValue}} in the service entry via E2E Console or in your UML-Model then this is not a value for this but a link/alias to a global setting. The value can be set at the “Setting Variables” Tab at the xUMLServices entry on the left hand side of the E2E Console navigation.

If you click at the “Plus” sign you will see all services that are using this global setting.