Job Opportunities

To submit any new job opportunities for this list, please email [email protected]. List the employer, location, closing date if applicable, and a link to more information. Jobs are removed after 3 months, unless requested otherwise.

This free job bulletin board aims to help scientists identify job opportunities in the field of amyotrophic lateral sclerosis (ALS) and/or frontotemporal dementia (FTD). Positions described as broadly spanning neurodegenerative diseases (NDG) are noted as ‘NDG‘. The job listing includes research positions at all levels, as well as non-research positions for which a research background at the MS, PhD, or MD level is required.

The Department of Neurosciences, Case Western Reserve University School of Medicine invites applications for a tenure-track faculty position at the rank of Assistant or Associate Professor. We seek applicants who utilize innovative methodological approaches to investigate basic mechanisms of neural development, regeneration, or neural circuit function and how perturbation of these mechanisms contributes to neurological, neurodegenerative, and/or psychiatric diseases. The new investigator will have the opportunity to interact and collaborate with a diverse group of individuals in basic science and clinical departments within the School of Medicine, University Hospitals Cleveland Medical Center, Cleveland Clinic, Louis Stokes Cleveland VA Medical Center, and MetroHealth Medical Center. Case Western Reserve University has an outstanding infrastructure for biomedical research including recently renovated animal facilities and core facilities supporting state-of-the-art methodologies in cellular and whole animal imaging, behavioral analyses, and proteomics and genomics. Case Western Reserve University School of Medicine has committed significant resources for major expansion of neuroscience research.

Applicants for a position as Assistant Professor should have a Ph.D. and/or M.D. degree, 3 to 5 years postdoctoral experience, and a strong record of scholarly activity. Candidates for appointment as Associate Professor should have these credentials and be nationally recognized scholars with a strong, externally funded research program.

Applications should include a cover letter, curriculum vitae, statement of research interests, names of three references and be submitted electronically at http://apply.interfolio.com/57451. The Interfolio application site will open on December 1, 2018 and close on January 28, 2019. For technical questions about your application, please contact Interfolio directly at 877-997-8807 or [email protected]

We are seeking a highly motivated data scientist to help us develop new technology to monitor debilitating neurological conditions. Nerve and muscle diseases, such as motor neurone disease, cause progressive paralysis. Many of these conditions have no cure and new research is held back by the lack of a means to determine disease progression.

Electrical impedance spectroscopy (EIS) is a simple, non-invasive way of assessing muscle health in which an imperceptible electrical current is passed through the muscle. We have developed a novel approach to EIS which assesses muscle architecture in greater detail than previously possible.

The aim of this project is to identify disease and track change over time by applying advanced signal processing techniques to real patient data. Through this work you will develop a new way for clinicians to diagnose and monitor patients with nerve and muscle diseases.

This exciting PhD is a collaboration between scientists at the Sheffield Institute for Translational Neuroscience (SITraN) and the Department of Automatic Control and Systems Engineering. You will work closely with clinicians and engineers and gain experience of multi-disciplinary team science.

The project will require candidates to have excellent mathematical and/or computational skills. Prospective candidates should have a good honours degree (Class 1 or 2:1) in Control, Electrical or Mechanical Engineering, Computer Science, Mathematics, Physics or other related disciplines.

Funding

A fully funded studentship provided by the Engineering and Physical Science Research Council (EPSRC) is available. The start date can be either March or October 2019.

The funding lasts for 3.5 years and includes Home/EU fees, as well as tax-free stipend at the UK Research Council rate (£14,777 for 2018/19). UK nationals and non-UK EU students who have been resident in the UK for 3 years prior to the start of the studentship are eligible to apply.

At the Jena University Hospital (JUH), Institute of Human Genetics (Director Prof. Dr. Christian Hübner), application are invited for a Professorship (W2 with tenure track to W3) for Cell Biology of Neurodegenerative Diseases. The person to be appointed will represent the subject in research and teaching. There is also the possibility to participate in medical services. It is expected that the appointee strengthens the faculty’s research foci.

Requirements include a university degree in a life science, postdoctoral thesis (Habilitation) or equivalent scientific qualification and teaching skills. The candidate should have an outstanding track record in publications and extramurally funded research.

The successful candidate will be employed for six years first. On a successful completion of the Tenure review after six years of employment, the position will be promoted to a professorship paid on salary scale W3 without additional selection procedure.

The JUH and Friedrich Schiller University Jena are committed to increasing the number of women in research and teaching. Therefore, JUH and the University actively encourage qualified female scientists to apply. In case of equal qualifications, applicants who have a disability will be favoured over the others.

Please note the guidelines about the application documents which can be found on https://www.uniklinikum-jena.de/appointment.html. Your application is received by the Dean Prof. Dr. K. Benndorf, Faculty of Medicine of Friedrich Schiller University, Bachstr. 18, 07743 Jena until January 8, 2019.

We are seeking to recruit new Group Leaders at junior or midcareer level. We offer attractive start-up packages and state-of-the-art laboratories and infrastructures to young group leaders, typically as a first independent position specialised in non-human primate (patho)physiology of neurodegenerative diseases (e.g. Alzheimer Disease & Parkinson Disease), or in chemical biology, biosensors, structural biology, physical chemistry of molecular assemblies, cell biology and synapse physiology, modelling from molecular and cellular mechanism to neural circuits, all for neuroscience applications.

Neuroscience in Bordeaux, France, has grown over the last 10 years to become one of the largest scientific communities in the field of Neuroscience in Europe. Encompassing a total of 650 international scientists organized in 6 main independent research centers, 10 core facilities and the Bordeaux School of Neuroscience, the neuroscience in Bordeaux, France, constitutes an exciting international environment with worldwide recognition in the fields of addiction, brain imaging, synapse biology, memory and dementia, sleep, attention and cognition, movement disorders, pain and sensory functions, pathophysiology of brain development, nutrition and neuro-inflammation.

Two major site grants enable to position Bordeaux Neurocampus as a foremost center to meet the challenges of brain research. The Neurocampus project, fully supported by the University of Bordeaux, CNRS, INSERM and the Aquitaine Regional Government, consists into the extension of Neurocentre Magendie (+ 8 000 m2) and of the construction of a 12 000m2 new building which hosts laboratories, animal facilities and the Bordeaux Imaging Center. It also supports the installation of new international research teams, start-up companies and medical patients’ association.

We expect candidates to develop a competitive, independent research program in his/her respective field, local collaboration and integration into the Bordeaux neuroscience community. Applicants should hold a PhD or MD/PhD degree, with a record of outstanding training and exceptional research potential. Applications from abroad are expressly welcome. We strive to increase the proportion of female staff and expressly encourages qualified women to apply.

We are seeking a part-time Research Assistant in Motor Neuron Disease to join the Nuffield Department of Clinical Neurosciences (NDCN). The post offers the opportunity to become proficient in the culture of fibroblasts, and motor and cortical neurons from iPSCs and to gain experience in neurodegeneration research as it relates to motor neuron disease (amyotrophic lateral sclerosis). As such the post would be very suitable for a bioscience graduate who is considering going on to study for a doctorate in neuroscience.

Your key responsibilities include, but are not limited to: the provision of research support for the Motor Neuron Disease research group, contributing to: the maintenance and analysis of neuronal cultures derived from induced pluripotent stem cells (iPSCs) from patients seen in the Oxford Motor Neuron Disease clinic; the processing and biobanking of biosamples (blood, urine, cerebrospinal fluid and skin biopsies) from patients participating in a major biomarker research project entitled ‘A Multicentre Biomarker Resource Strategy in ALS’ (AMBRoSIA).

You will have experience of following and adapting laboratory protocols and selecting appropriate experimental methodologies, pursue a degree in a relevant discipline (e.g. biological sciences, including neuroscience), possess sufficient specialist knowledge in the discipline to work within the established research programmes, along with excellent communication skills, including the ability to write text that can be published, present data at conferences, and represent the research group at meetings.

The post is part-time (0.6 FTE) at 22.5 hours per week for a fixed-term of 12 months in the first instance.

Only applications received before 12.00 midday on Wednesday 4 January 2019 will be considered. Interviews will be held on 9 January 2019.

Dr. Anne Bang leads efforts at the Conrad Prebys Center for Chemical Genomics to develop patient cell specific and human induced pluripotent stem cell (hiPSC)-based disease models for drug screening and drug target identification. Her research program is primarily focused on neurological and neuromuscular disease, with the aim of designing human cell-based models and assays that reflect higher order cellular functions and recapitulate disease phenotypes, yet have the throughput and reproducibility required for drug discovery.

The successful candidate will be primarily responsible for conducting research related to developing patient specific, cell based, “disease in a dish” models for neurological disease to screen for drugs, validate new targets and chemical molecules, and probe underlying cellular and molecular processes. The project will focus on the development of models representing neurological disease phenotypes, using patient specific induced pluripotent stem cells (iPSC), and will utilize high throughput drug screening technologies.

Applications are invited for the position of Director of the Tanz Centre for Research in Neurodegenerative Diseases (Tanz Centre) in the Faculty of Medicine at the University of Toronto, CANADA.

The incoming Director will be an internationally recognized leader in neurodegeneration research with the experience to catalyze research—from fundamental neuroscience and cellular mechanisms to translation research—in all areas of neurodegenerative diseases with a commitment to open data and open science. They will have a record of successful collaborative leadership and possess outstanding relationship and business acumen to create and engage partnerships across a complex network of healthcare institutions.

The successful candidate will be deeply committed to excellence in education, demonstrate teaching excellence at both the undergraduate and graduate program levels, and have significant experience as an effective mentor/supervisor. They will be expected to pursue innovative research at the highest international level and to maintain and lead a strong, independent, externally-funded research program. Experience and/or enthusiasm in fundraising would be an asset. The successful candidate must have a clear vision and demonstrated ability to take the Tanz Centre to an even higher level of achievement and international recognition.

The successful candidate will have a PhD and/or medical degree in a related discipline. They must either hold or be eligible for a faculty appointment at a senior academic rank at the University of Toronto at a level of accomplishment for a competitive funding package. The Faculty of Medicine is currently in a campaign to raise philanthropic funds to support the incoming Director of the Tanz Centre and their priorities.

Qualified candidates are invited to apply online. Applicants should submit a single PDF that includes (in order) (1) a cover letter, (2) a curriculum vitae, (3) a statement of current and long-term research interests (three to five pages), (4) a statement of teaching philosophy (one page), and (5) three letters of reference. Submission guidelines are available for consultation.

The ALS Center for Cell Therapy and Regeneration Research at Johns Hopkins is seeking a postdoctoral fellow to participate in research utilizing human induced pluripotent stem cell models of neurodegenerative disease, with an emphasis on motor neuron diseases (ALS). The fellowship will use stem cell methodologies to both investigate disease pathogenesis as well as evaluate potential therapeutics. There is also a programmatic interest in the investigation of astrocyte-mediated contributions to the progression of disease in ALS with an emphasis on human iPSC-derived astrocyte biology and electrophysiology.

Preference will be given to candidates whose research is related to the pathogenesis of neurodegenerative disorders and/or stem cell biology.

Interested candidates should have a Ph.D. or M.D. degree, and a demonstrated capacity to perform creative and original research. Interested applicants should send their resumes by email to Dr. Nicholas J. Maragakis at [email protected]

The Department of Neuroscience in the College of Medicine at the University of Kentucky (https://neuroscience.med.uky.edu/) invites applications for a tenure-track faculty position at the rank of Assistant, Associate, or Full Professor. Applicants who study the mechanisms of central nervous system function and plasticity are encouraged to apply. The research interests of newly appointed faculty will complement those of existing collaborative teams within the Department and across the College studying neurotrauma, epilepsy, stroke, aging, neurodegenerative diseases, and motivated behaviors. New faculty will also contribute to graduate training and to the neuroscience or anatomical science teaching missions of the department. Qualified candidates should have earned a Ph.D. or equivalent degree and have at least three years of postdoctoral experience in neuroscience or a related field, with a strong record of scholarly activity and clear potential to secure extramural funding for their research program. Candidates applying for appointment at the rank of Associate or Full Professor should also be nationally or internationally recognized scholars with consistent externally funded research programs.

Application materials should be emailed to Ms. Avalon Sandoval ([email protected]) and should include: 1) a cover letter addressed to Bret N. Smith, PhD, Professor and Chair, Department of Neuroscience, University of Kentucky College of Medicine; 2) curriculum vitae; 3) a two to three page description of research plans; 4) a statement of teaching interests; 5) two recent key publications; and 6) names/contact information for at least three references. The Search Committee will begin reviewing applications on December 7, 2018; the search will remain open until the position is filled. If offered this position, you will be required to pass a pre-employment drug screen and undergo a pre-employment national background check as mandated by University of Kentucky Human Resources.

At TU Dresden the Junior Research Group of Dr. Jared Sterneckert, “iPS Cells and Neurodegenerative Disease” at the Center for Regenerative Therapies Dresden (CRTD), an Institute of the Center for Molecular and Cellular Bioengineering (CMCB), is calling for applications for a PhD scholarship. The Scholarship starts as soon as possible and is initially limited until Aug 30th 2020 with an optional extension. Dr. Sterneckert’s group uses patient specific induced pluripotent stem (iPS) cells to generate models of neurodegenerative diseases, including Parkinson’s disease and amyotrophic lateral sclerosis. Using a combination of gene editing, proteomics, and small molecules, we aim at understanding the mechanism(s) of pathogenesis and identifying novel treatments. The aim of this project is to use iPS cell-derived neurons in combination with patient biosamples to study amyotrophic lateral sclerosis, particularly the role of exosomes.

An exciting opportunity has arisen for a Technician in the Sheffield Institute for Translational Neuroscience (SITraN). SITraN is a purpose built research facility which was opened in November 2010 by Her Majesty the Queen. The Institute houses clinical and basic scientists from the Department of Neuroscience and the primary focus is research into neurodegenerative disorders such as Motor Neurone Disease (MND), Parkinson’s disease and Alzheimer’s disease.

We are seeking an enthusiastic and experienced individual to join the core technical team within SITraN and provide research technical support for an exciting new role within SITraN. You will be responsible for running high-throughput drug screenings for Pharma companies and maintaining human and mouse stem cells. You will learn how to culture Human fibroblasts and then reprogram into induced neural progenitor cells and maintain the progenitors for further differentiation into human astrocytes and neurons. You will learn a number of cutting edge techniques and your role will be embedded in a very dynamic research group.

The salary is £19,202 to £21,414 per annum. Potential to progress to £23,334 per annum through sustained exceptional contribution.

We invite applications for a tenure review eligible faculty position at the rank of Assistant, Associate or Full Professor in the Brain and Mind Research Institute and in relevant Graduate Training Programs at Weill Cornell Medicine. Primary criteria for appointment will be outstanding records of innovative research, academic performance and commitment to disease-focused neuroscience. Of particular interest are applicants who are using electrophysiology, imaging, immunology, and computational approaches to unravel mechanisms of major brain disorders such as Alzheimer’s disease and related conditions. Demonstrated ability to attract independent grant support is another selection criterion. Additional requirements include a medical or doctoral degree, and at least four years of teaching experience (during residency, fellowship, and/or in the lab) by the time the appointment becomes effective.

Women and underrepresented minorities are especially encouraged to apply. The search will continue until the position is filled. However, to ensure full consideration, applications should be received by November 15, 2018.

Please send your curriculum vitae, a description of achievements and research interests, and the names of three references to: Marcella Garvey at [email protected]

The Stefan Pulst / Daniel Scoles Neurology Laboratory group at the University of Utah, Department of Neurology, invites applications for a postdoctoral fellowship for the study of cerebellar ataxia and other neurodegenerative diseases using calcium imaging and electrophysiological recordings. The Neurology Laboratory is well-funded by NIH, and other funding sources. We seek a highly motivated PhD in a related medical science who is interested in carrying out research on how RNA granules control localized calcium abundance and neuronal function in cultured cells and acute brain slices. The research objectives include understanding mechanisms of neurodegenerative disease as well as testing novel therapeutics in disease models.

The postdoc will join a well-established research program focused on developing therapeutics for cerebellar ataxia, amyotrophic lateral sclerosis, and other neurodegenerative disorders. The cellular mechanisms underlying these neurodegenerative diseases will be evaluated using a combination of two-photon imaging to monitor calcium abundance changes, live imaging for monitoring the movement of RNA granules, and electrophysiological recordings.

The Laboratory of Molecular Biology at The Rockefeller University is seeking a highly motivated and outstanding candidate for a postdoctoral position to study the selective vulnerability and degeneration of upper motor neurons in amyotrophic lateral sclerosis (ALS). ALS presents a paradox in that most known disease-causing mutations are ubiquitously expressed, yet only discrete populations of cells degenerate. We therefore use a multidisciplinary approach, centered on advanced molecular profiling methods to elucidate cell type-specific phenotypes during disease progression in preclinical mouse models and postmortem human tissue. By contrasting vulnerable and resilient neuronal populations as well as non-neuronal cells, we hope to identify novel disease mechanisms and putative entry points for therapeutic intervention These studies are also integrated with modern anatomical and circuit-tracing methods and behavior to map the identity, connectivity, and function of neuronal cell types in cortical and motor circuits.

The ideal candidate will have a Ph.D. in neuroscience or a related field and have prior research experience in molecular or cellular biology. Preference will also be given to those with familiarity with at least one of the following: next generation sequencing, quantitative analysis of sequencing data, animal models of CNS disorders, neuroanatomy and immunohistological methods, and/or functional circuit-mapping. Candidates must also demonstrate a strong track record of research productivity, scientific rigor, excellent communication skills, and an ability to work both independently and as part of a team.

Interested applicants should send a cover letter, CV, and names and contact information of three (3) references to Dr. Eric Schmidt ([email protected]). Applications will be accepted until the position is filled.

Applications are invited for a position at the level of full professor. The Department of Neurobiology and Behavior is ranked as one of the top neuroscience departments in the country and engages in interdisciplinary approaches to the study of neurobiology. We seek outstanding candidates whose research addresses neuroimmunology with application to human neurological disease using multiple approaches including model systems. Areas may include neuroinflammatory responses due to viral infection of the CNS, the role of the immune system in demyelinating diseases such as Multiple Sclerosis, or in other neurodegenerative diseases. Applicants should hold a Ph.D., M.D., or equivalent degree and have an international reputation with an impactful, collaborative and well-funded research program. Desire to contribute to both teaching and mentorship at the undergraduate and graduate level and participate in leadership and mentoring at UCI and within their field is required. Please submit by December 15, 2018, curriculum vitae, a description of research and teaching interests, and the names and addresses of three potential referees. A separate statement that addresses past and/or potential contributions to diversity, equity and inclusion should also be included in the application materials. For application instructions, please go to the Department of Neurobiology and Behavior Professor section at https://recruit.ap.uci.edu/apply/JPF05003. Information on the department is available at http://neurobiology.uci.edu.

Applications are invited for a senior research officer post to join a cross-disciplinary drug discovery group focussed on developing new therapies for neurodegenerative disorders. Located within the School of Medicine, University of Edinburgh, the successful candidate will play a key role in a cross-institute drug discovery initiative which represents a collaboration between the Centre for Clinical Brain Sciences, the Centre for Discovery Brain Sciences and the Institute of Genetics and Molecular Medicine. They will work in a dynamic multi-disciplinary environment using state-of-the-art cell biology and imaging techniques to advance phenotypic screening and drug discovery in neurodegenerative disease.

The successful candidate will have significant laboratory experience in mammalian cell culture techniques, cellular pharmacology and chemical library screening including use of robotic liquid handling systems. Further expertise in automated high content fluorescent imaging and image-analysis are desirable.

Informal inquiries are welcomed and can be sent to Prof Neil Carragher ([email protected]).

We are seeking a motivated post-doctoral fellow who works well with others as part of a research team. The ability to design, conduct, and report on research experiments is required. Communication skills, organizational skills, and a willingness to learn new approaches are of paramount importance. The fellow will pursue the underlying causes of aging associated protein aggregation in neurodegenerative disease using genome editing approaches in C. elegans and/or mammalian model systems.

This Fellow position is in the Kraemer Group at the University of Washington in Seattle (https://depts.washington.edu/mbwc/about/profile/brian-c.-kraemer). The Kraemer Group studies proteostasis and neurodegeneration in aging related dementia disorders. We use a variety of model systems (C. elegans, cultured human cells, and mice) to model the neurodegeneration seen in Alzheimer’s disease and frontotemporal lobar degeneration/amyotrophic lateral sclerosis, and related aging associated dementia disorders.

A postdoctoral position is available to study the maintenance, degeneration and regeneration of spinal motor neurons. Of particular interest for this position is the investigation of the intrinsic regenerative capacity of motor neurons, and how this is impaired during the pathogenesis of ALS. The laboratory employs state-of-the-art cellular, molecular, biochemical, mouse transgenic and imaging approaches for the interrogation of circuit development and physiology. The laboratory environment is energetic, collegial, highly collaborative, and strives for excellence. For a detailed description of our research goals visit the laboratory website.

Please send a cover letter including a brief statement of research interests, a CV, and the names and contact information of 3 references to: Brian A. Pierchala

Brian A. Pierchala, Ph.D.

Department of Biologic and Materials Sciences

University of Michigan

1011 N. University

Ann Arbor, MI 48109 USA

Candidates should have a Ph.D. in Neuroscience or a closely related biomedical field and have a thorough background in neurobiology, cell biology, and biochemistry. Although not necessary, some familiarity with electrophysiological techniques would be of interest. Applicants must also possess excellent oral and written communication skills.

Tenure-track Assistant Professor of Biology in Neurobiology of Disease to teach courses in neuroscience, human physiology, anatomy, or cell biology; develop an active research program leading to publications and external funding; advise undergraduate and graduate students; and provide service to the institution.

Consideration may be given to: physiologists with research on nervous system disorders, including genetic and developmental neurological disorders, neurodegenerative diseases, neuroimmunological and inflammatory disorders, autoimmune diseases, or related areas; candidates who would use animal, cell/tissue, or computational model systems, and employ modern molecular, cellular, physiological, or imaging techniques to advance our understanding of neurobiological disease.

Submit cover letter, curriculum vitae, statement of research plans, and teaching philosophy to https://miamioh.hiretouch.com/job-details?jobID=6483. The department will solicit reference letters from references provided in application. For inquiries about posting, contact Thomas Crist at [email protected]. Screening of applications will begin November 9, 2018 and will continue until the position is filled.

The RIKEN Center for Brain Science (CBS) was launched in April 2018 following the strong 20-year foundation of its predecessor, the Brain Science Institute (BSI). CBS aims to meet society’s ever-growing expectations for brain research.

Now we are newly seeking outstanding neuroscientists for tenure-track Team Leader positions (equivalent to U.S. Assistant or Associate Professors). However, exceptional applications from internationally established neuroscientists may be considered for tenured Team Leader positions (equivalent to U.S. Full Professors). This is our first round of faculty recruitment at CBS, and in the coming several years CBS plans to open approximately 10 new Team Leader positions for outstanding neuroscientists.

At RIKEN CBS, Team Leaders have full intellectual independence, generous internal funds including a highly competitive start-up package and access to ample communal facilities in a collaborative environment. Successful candidates for the Team Leader position must have demonstrated the ability to develop an original, independent and internationally competitive research program.

We encourage applications from all disciplines of neuroscience at the molecular, cellular, circuit, systems and/or cognitive levels using any model animals and/or involving human subjects. Neuroscientists with research interests in psychiatric/neurological diseases or computational/theoretical approaches are also encouraged to apply.

Applications received by the end of November 2018 will be screened in the first round of review, although the call will remain open until the positions are filled.

Applicants should submit the electronic files of a cover letter with a brief summary of their research program and plan, curriculum vitae with copies of five major publications, a detailed statement of current and proposed research, and the names, affiliation and contact details (telephone no. and email address) of three referees along with the information about their relationship to the applicant, to the following address . In addition, the applicants are requested to arrange for the three reference letters to be sent directly to the same address . If possible, one of the three referees should be the current supervisor, and the letters should be signed and addressed to Dr. Yasushi Miyashita, Director of RIKEN Center for Brain Science. All files and recommendation letters should be written in English.

The Center for Computational and Integrative Biology (CCIB) at Massachusetts General Hospital and Harvard Medical School are seeking to hire a talented and enthusiastic individual as a tenure-track Assistant Professor to lead an independent research laboratory in computational biology, systems biology or a related discipline that focuses on one or more of the following areas closely linked with experimental science within the CCIB: inflammation and autoimmunity, infectious diseases and mechanisms of host pathogen interactions, metabolism, neuroscience and cancer. The successful applicant will be expected to develop a vigorous independent research program, secure and maintain extramural research funding, form collaborative projects with other faculty within the CCIB and participate in graduate and postdoctoral training.

The Department of Biological Sciences of Augusta University invites applications for a tenure-track position at the rank of Assistant Professor to begin in August 2019. The Department is composed of 22 full-time and 7 part-time faculty members with expertise across a broad spectrum of biological disciplines. We have a strong commitment to providing research opportunities and experience to our undergraduate students in addition to excellent classroom and laboratory instruction. As a thriving unit in this research university, faculty in the Department of Biological Sciences have both the opportunity and expectation to help develop new undergraduate and graduate programs in the biological sciences. Within the next academic year, we expect to launch our first master’s program in Biomolecular Sciences, and the faculty member hired for this position will be an integral part of this emerging program.

Applicant must possess a Ph.D. or equivalent terminal degree, preferably with postdoctoral experience in the area of Neurobiology, Neuroscience or a closely related field and have a strong commitment to excellence in research and teaching both graduate and undergraduate students. The successful candidate is expected to establish a vigorous externally funded research program focusing on neuroscience, including a neurodegenerative condition such as movement disorders, stroke, or dementia. Additionally, applicants must possess the credentials to teach courses such as neuroscience, cell biology, and graduate courses. The normal teaching load for this position will be approximately two courses per academic year, and applicants must have a strong commitment to excellence in teaching undergraduates.

Apply online at https://www.augusta.edu//hr/jobs/faculty/ . Scroll to the bottom of the page and click “Open Positions for External Applicants.” Then, search for the position using the Keywords: Assistant Professor of Biology. Next click on Job Opening ID number: 13820, and attach a single pdf containing 1. letter of application, 2. curriculum vitae, 3. statement of your teaching philosophy, 4. description of your current and/or proposed research project, and 5. graduate transcripts (unofficial copies are acceptable for initial applicant screening). Additionally, please arrange to have three letters of reference sent directly from each author to: Ms. Brenda Brunk ([email protected]), Administrative Assistant in the Department of Biological Sciences. Review of applications will begin December 1, 2018 and will continue until the position is filled.

The Centre for Brain Research (CBR), an autonomous centre of Indian Institute of Science, invites applications for the position of faculty. CBR is dedicated to finding early diagnoses and rational therapies for neurodegenerative diseases through better understanding of brain function. CBR fosters inter-disciplinary neuroscience research and is currently recruiting neuroscientists, clinicians, engineers and computational scientists, who would work together to reduce the burden of dementia and other neurodegenerative disorders.Candidates with experience in cognitive neuroscience, epidemiology, brain imaging, computer science and genetics are encouraged to apply.

The Department of Biology at the University of Massachusetts, Amherst invites applications for a tenure-track position at the rank of Assistant or Associate Professor. The successful candidate will also be a part of the Institute for Applied Life Sciences (see IALS), which has the goals of developing translational research programs, fostering interactions with industry, and training a translational life sciences workforce. New faculty members will be able to take full advantage of the substantial investments in campus infrastructure and core facilities made by IALS (see IALS Cores for details).

We are seeking a new faculty member who will establish a research program with high translational potential that utilizes animal models or human-derived cells to develop mechanistic insights and therapeutic approaches into neurological disorders. Areas of interest include, but are not limited to, neurodegenerative diseases such as Alzheimer’s or Parkinson’s Diseases and recovery from acute injuries such as traumatic brain injury or stroke. We are particularly interested in candidates whose research programs augment our existing strengths in neuroscience (see UMass Initiative on Neurosciences (IONS), Neuroscience and Behavior Graduate Program) and extends this expertise directly into health-related areas (IALS, Models to Medicine Center).

Review of applications will begin on November 5, 2018 and will continue until the position is filled. Online applications can be uploaded below and should include a cover letter, CV, research plan, teaching statement, contact information for three references, and a Statement of Contribution to Diversity, Equity and Inclusion.

The Department of Pathology (http://pathology.ucsd.edu) and the Department of Neurosciences (http://medschool.ucsd.edu/som/neurosciences) at the University of California San Diego is committed to academic excellence and diversity within the faculty, staff, and student body.

The neurodegenerative disease research community at UC San Diego is highly collaborative group and we are seeking exceptional scientists with neurodegeneration research programs for a tenured faculty position at the Associate or Full Professor level.

Candidates are also expected to teach as well as perform research training and university service. Considerable opportunity exists for collaboration within our robust clinical enterprise and with the UCSD Alzheimer’s Disease Research Center.

Candidates must have an M.D. and/or Ph.D. degree and must be board certified/board eligible with the ability to obtain a California Medical License. Candidates must have a demonstrated track record of scholarly achievement, research excellence, and an interest in further contributing to the exceptional programs in neurosciences at UCSD through collaboration. Candidates must have an innovative research focus in neurodegeneration. Qualified candidates must be able to develop and sustain outstanding extramurally funded research programs.

Appointment will be at the Associate or Full Professor level. Series will include 100% Ladder rank or 50% Ladder Rank and 50% In-Residence with secured extramural funding. Salary is commensurate with qualifications and based on University of California pay scales.

Industry

We are seeking an experienced and highly motivated neurobiologist to contribute to our research team at our facility in Cambridge, Massachusetts. This is an ideal position for an individual with a strong background in in vivo experimental methods and readouts, who thrives in a team-oriented, fast-paced, and cross-disciplinary start-up biotech environment. The individual will work in the laboratory and be responsible for experimental execution and data analysis for research studies supporting therapeutic programs and platform discovery research in neurodegenerative disease areas. The successful candidate will have extensive prior experience in drug discovery in neurodegenerative diseases including hands-on techniques in stereotaxic surgery, in vivo behavioral assays of rodent models, CNS tissue dissection, and tissue analysis (such as RT-qPCR, western blot and ELISA).

AveXis, Inc., a Novartis Company, is a clinical-stage gene therapy company, dedicated to developing and commercializing novel treatments for patients suffering from rare and life-threatening neurological genetic diseases. Our initial product candidate, AVXS-101, is our proprietary gene therapy product candidate currently in development for the treatment of spinal muscular atrophy, or SMA, Type 1, the leading genetic cause of infant mortality, and for the treatment of SMA Type 2. The U.S. Food and Drug Administration, or FDA, has granted AVXS-101 Orphan Drug Designation for the treatment of all types of SMA and Breakthrough Therapy Designation, as well as Fast Track Designation for the treatment of SMA Type 1. In addition to developing AVXS-101 to treat SMA Type 1 and Type 2, we also plan to develop other novel treatments for rare neurological diseases, including Rett syndrome (RTT) and a genetic form of amyotrophic lateral sclerosis (ALS) caused by mutations in the superoxide dismutase 1 (SOD1) gene.

The Associate Director will be responsible for generating reports to update senior management on all aspects of the research and development function, while maintaining appropriate documentation of all studies. The position will serve as a knowledge resource to the company on the latest gene therapy research and a subject matter expert on the biology of neuromuscular diseases. The successful candidate will take accountability to ensure all projects requiring research and development resources are adequately resourced and tracking to timelines.

AveXis, Inc., a Novartis Company, is a clinical-stage gene therapy company, dedicated to developing and commercializing novel treatments for patients suffering from rare and life-threatening neurological genetic diseases. Our initial product candidate, AVXS-101, is our proprietary gene therapy product candidate currently in development for the treatment of spinal muscular atrophy, or SMA, Type 1, the leading genetic cause of infant mortality, and for the treatment of SMA Type 2. The U.S. Food and Drug Administration, or FDA, has granted AVXS-101 Orphan Drug Designation for the treatment of all types of SMA and Breakthrough Therapy Designation, as well as Fast Track Designation for the treatment of SMA Type 1. In addition to developing AVXS-101 to treat SMA Type 1 and Type 2, we also plan to develop other novel treatments for rare neurological diseases, including Rett syndrome (RTT) and a genetic form of amyotrophic lateral sclerosis (ALS) caused by mutations in the superoxide dismutase 1 (SOD1) gene.

Scientist, Research and Development is responsible for executing in vivo experiments for AveXis programs. This individual will work in the vivarium and laboratory, responsible for execution of experiments related to existing and pipeline products. This individual will report to a Senior Scientist in Research and Development.

An opportunity exists for a leading candidate with a strong scientific background in neuroscience and a track record of success in drug discovery to contribute to Astex’s expanding drug discovery portfolio in CNS and oncology. The successful candidate will be highly-motivated with demonstrated technical ability and the capacity to think independently and creatively. They should be an excellent communicator, able to interact with both internal multi-disciplinary project teams and external experts in the field. This is an exciting opportunity to contribute your in-depth knowledge of neuroscience to drug discovery and to drive future success and innovation in neurodegeneration projects at Astex.

Voyager Therapeutics is seeking an experienced and highly motivated neurobiologist to contribute to our research team at our facility in Cambridge, Massachusetts. This is an ideal position for an individual with a strong background in in vivoexperimental methods and readouts, who thrives in a team-oriented, fast-paced, and cross-disciplinary start-up biotech environment. The individual will work in the laboratory and be responsible for experimental execution and data analysis for research studies supporting therapeutic programs and platform discovery research in neurodegenerative disease areas. The successful candidate will have extensive prior experience in drug discovery in neurodegenerative diseases including hands-on techniques in stereotaxic surgery, in vivo behavioral assays of rodent models, CNS tissue dissection, and tissue analysis (such as RT-qPCR, western blot and ELISA).

At Tiaki, we discover first-in-class small molecule therapeutics to provide disease modifying benefit to patients suffering from age-related dementias. To accomplish this we focus on discovering drugs that return chronically activated microglia, found in neurodegenerative conditions, to CNS protective microglia found in the healthy brain. Tiaki is a venture-backed start up located at Lab Central.

Tiaki is seeking a talented bench scientist to expand our biology team to four scientists. The candidate must have start-up biotech experience and be highly motivated, collaborative, and team-oriented with strong laboratory skills. The ideal candidate has experience in CNS disease drug discovery and knowledge of microglial and/or neuronal biology. The position requires knowledge of in vitro techniques, including primary cell and tissue culture, various in vitro CNS cellular assays, gene expression analysis, and protein quantification. Experience with immunohistochemistry and microscopy is a plus. Assay development experience is preferred. The scientist will work intimately with all members of the team in order to develop microglia-targeted therapeutics for dementia.

The Department of Cell Biology and Neuroscience (CBN) invites applications for a tenure-track faculty position at the Assistant Professor level to develop an innovative and interdisciplinary research program in neuroscience. Priority will be given to outstanding applicants whose research focuses on neurophysiological analysis of single cells and circuits in the mammalian brain. The successful candidate will be expected to contribute to the teaching of undergraduate and graduate level courses in her/his field of expertise, and maintain a productive extramurally funded research program.

Stanford Medicine is committed to the vision of excellence in all allied fields within the neurosciences. The Stanford Department of Pathology embraces this vision, and accordingly here we announce our intent to recruit an outstanding physician-scientist with major focus in investigative neuropathology, ideally with a strong interest and record of accomplishment in neurodegenerative diseases. Based on the applicant’s qualifications and career goals, candidates may be hired in any rank of the University Tenure Line (UTL) or Medical Center Line (MCL). The successful candidate will be appointed at the rank of Assistant, Associate or Full Professor, which will be determined based on qualifications and experience of the candidate.

We are seeking a part-time Research Assistant in Motor Neuron Disease to join the Nuffield Department of Clinical Neurosciences (NDCN). The post offers the opportunity to become proficient in the culture of fibroblasts, and motor and cortical neurons from iPSCs and to gain experience in neurodegeneration research as it relates to motor neuron disease (amyotrophic lateral sclerosis). As such the post would be very suitable for a bioscience graduate who is considering going on to study for a doctorate in neuroscience.

The Department of Neurology at the Perelman School of Medicine at the University of Pennsylvania seeks candidates for an Assistant Professor position in the non-tenure clinician-educator track. The successful applicant will have experience in the field of Neurology with a focus on Neuropsychology. Applicants must have a Ph.D. degree and have demonstrated excellent qualifications in clinical care and research. The successful applicant must have completed a two-year post-doctoral fellowship in clinical neuropsychology, and be board eligible or licensed to practice Neuropsychology.

The Department of Neurosciences, Case Western Reserve University School of Medicine invites applications for a tenure-track faculty position at the rank of Assistant or Associate Professor. We seek applicants who utilize innovative methodological approaches to investigate basic mechanisms of neural development, regeneration, or neural circuit function and how perturbation of these mechanisms contributes to neurological, neurodegenerative, and/or psychiatric diseases. The new investigator will have the opportunity to interact and collaborate with a diverse group of individuals in basic science and clinical departments within the School of Medicine, University Hospitals Cleveland Medical Center, Cleveland Clinic, Louis Stokes Cleveland VA Medical Center, and MetroHealth Medical Center. Case Western Reserve University has an outstanding infrastructure for biomedical research including recently renovated animal facilities and core facilities supporting state-of-the-art methodologies in cellular and whole animal imaging, behavioral analyses, and proteomics and genomics. Case Western Reserve University School of Medicine has committed significant resources for major expansion of neuroscience research.

We are seeking a highly motivated data scientist to help us develop new technology to monitor debilitating neurological conditions. Nerve and muscle diseases, such as motor neurone disease, cause progressive paralysis. Many of these conditions have no cure and new research is held back by the lack of a means to determine disease progression.

We are seeking to recruit new Group Leaders at junior or midcareer level. We offer attractive start-up packages and state-of-the-art laboratories and infrastructures to young group leaders, typically as a first independent position specialised in non-human primate (patho)physiology of neurodegenerative diseases (e.g. Alzheimer Disease & Parkinson Disease), or in chemical biology, biosensors, structural biology, physical chemistry of molecular assemblies, cell biology and synapse physiology, modelling from molecular and cellular mechanism to neural circuits, all for neuroscience applications.

The Department of Biology at the University of Massachusetts, Amherst invites applications for a tenure-track position at the rank of Assistant Professor. The successful candidate will be a part of the Institute for Applied Life Sciences (IALS), which has a primary goal of developing translational research programs and fostering interactions with industry.

The Center of Image Acquisition (CIA) at the USC Mark and Mary Stevens Neuroimaging and Informatics Institute seeks a qualified applicant for an Assistant Professor (tenure track) position in the USC Department of Neurology. The CIA serves as central resource for the development and application of advanced imaging for all neuroimaging research at the Keck School of Medicine of USC. The CIA will interact and collaborate with many departments at the Health Sciences Campus and the University Park Campus conducting research in methodology and its application in the study of normal, neurological and psychiatric cohorts. The ideal candidate should have a Ph.D. in Biophysics, Biomedical Engineering, or a related field, and have 2-3 years of postdoctoral training in the field of MRI physics and its applications in neuroscience. The candidate is expected to develop innovative MRI techniques, in particular noninvasive blood flow and perfusion imaging. The main duties of this position include the development of an independent and/or collaborative research program and participation in multidisciplinary research applying novel MRI imaging techniques for assessing and diagnosing neurovascular and neurodegenerative diseases. Experience on pulse sequence programming, particularly on Siemens platform is highly desirable.

The Department of Biological Sciences invites applicants for a tenure track faculty positions at the Assistant Professor level to begin September 1, 2019. We are seeking candidates with research interests directed at cellular and molecular mechanisms of aging and age-related diseases including but not limited to, neurodegenerative disorders, cancer, and diabetes. Individuals applying advanced cell biology, molecular, and genetic approaches, as well as animal models, are encouraged to apply. The successful candidate will have a Ph.D. and post-doctoral experience in an appropriate field, will develop an extramurally funded research program, will supervise Ph.D. and M.S. students and undergraduate research projects and will teach undergraduate and graduate courses in area of expertise. The candidate’s research program should augment the research directions in the Department of Biological Sciences. Information on Departmental programs can be found at http://www.du.edu/nsm/departments/biologicalsciences/

The Department of Biological Chemistry and Pharmacology, in the College of Medicine at The Ohio State University, invites applications from investigators using zebrafish as a model organism for a tenure-track faculty position at the rank of Assistant Professor. The successful candidate will join a vibrant and cohesive zebrafish community at The Ohio State University. The department has complementing strengths in motor neuron disorders, neuromuscular biology, RNA biology and epigenetics. There is also a college-wide program to enhance research in neurodegenerative diseases. Research programs that are in neurodegeneration or complement department strengths are particularly encouraged.

The Department of Biological Sciences in the School of Natural Sciences and Mathematics at the University of Texas at Dallas (http://www.utdallas.edu/biology/) invites applications for a faculty position at the rank of Assistant Professor. We seek to hire an outstanding scientist with research interests that complement and build on existing departmental strengths in biochemistry, cell and molecular biology, computational and systems biology, genomics, microbiology, and pathobiology (cancer, neurodegenerative disorders, and infectious disease). Since the department has the goal of expanding its research and teaching into new directions, we will also consider applications from excellent candidates in other areas of the biological sciences. Review of applications will begin immediately and will continue until the position is filled.

The Center for Computational and Integrative Biology (CCIB) at Massachusetts General Hospital and Harvard Medical School are seeking to hire a talented and enthusiastic individual as a tenure-track Assistant Professor to lead an independent research laboratory in computational biology, systems biology or a related discipline that focuses on one or more of the following areas closely linked with experimental science within the CCIB: inflammation and autoimmunity, infectious diseases and mechanisms of host pathogen interactions, metabolism, neuroscience and cancer. The successful applicant will be expected to develop a vigorous independent research program, secure and maintain extramural research funding, form collaborative projects with other faculty within the CCIB and participate in graduate and postdoctoral training.

The Department of Psychology at Tufts University is seeking applicants at the assistant professor level for a tenure-track position in computational clinical neuroscience to begin September 1, 2019. The successful candidate will have a Ph.D. (or be ABD) and an active research program capable of supporting extramural funding. Area of specialization is open, but candidates should use mathematical and computational modeling approaches (e.g., Bayesian, connectionist, reinforcement learning) and/or data science approaches in their research; candidates with research interests that bridge to those of other members of the department are of particular interest. Potential research areas might include, but are not limited to, characterizing core computational and/or neural network disruptions underlying psychological disorders; identifying neural markers that predict mental health problems and/or treatment response; testing predictions developed from computational models of basic perceptual, cognitive, or affective mechanisms in clinical populations; and applying advanced analytic approaches (e.g., multivariate analysis, machine learning) to complex neuroimaging datasets (including fMRI, EEG/ERP, and MEG).

The Virginia Tech Carilion Research Institute (VTCRI) has launched a new center within the institute – the Developmental and Translational Neurobiology Center (DTNC; https://wp.vtc.vt.edu/dtnc/), to expand the institute’s research programs in cellular and molecular neurobiology in healthy development, disease, and trauma. There are currently two open assistant professor faculty positions – one for a neurobiologist studying mechanisms underlying brain development or neurodevelopmental disorders and one for a neurobiologist or neuro-immunologist studying neurodegenerative disease or brain injury. Applicants should have an earned doctorate, have completed postdoctoral training and demonstrated a track record of successful research, publications and either active extramural funding (preferably from NIH) or show distinct promise to obtain such funding. The new faculty will join a collaborative and highly successful group of investigators at the VTCRI with related research interests in a variety of areas of neuroscience. Competitive salary, space and start-up packages will be provided.

The Virginia Tech Carilion Research Institute (VTCRI) has launched a new center within the institute – the Developmental and Translational Neurobiology Center (DTNC; https://wp.vtc.vt.edu/dtnc/), to expand the institute’s research programs in cellular and molecular neurobiology in healthy development, disease, and trauma. There are currently two open assistant professor faculty positions – one for a neurobiologist studying mechanisms underlying brain development or neurodevelopmental disorders and one for a neurobiologist or neuro-immunologist studying neurodegenerative disease or brain injury. Applicants should have an earned doctorate, have completed postdoctoral training and demonstrated a track record of successful research, publications and either active extramural funding (preferably from NIH) or show distinct promise to obtain such funding. The new faculty will join a collaborative and highly successful group of investigators at the VTCRI with related research interests in a variety of areas of neuroscience. Competitive salary, space and start-up packages will be provided.

The Centre for Integrative Biology of the University of Trento invites candidates active in Genetics to apply for a position at the Assistant Professor level. The position is offered for a three-year period. The annual gross salary will be about 45.000 Euros. The area of research and teaching is Genetics:

The Department of Cell Biology at Emory University School of Medicine seeks outstanding applicants to fill a tenure-path faculty position at the Assistant Professor level in the areas of Neurological Disease, including Neurodevelopmental Disorders or Neurodegeneration.

The Center for Neuroscience (CNS) and the Department of Microbiology & Molecular Genetics (MMG) in the College of Biological Sciences at the University of California, Davis invites applications for a 9-month, tenure-track position at the ASSISTANT PROFESSOR level to begin July 1, 2019 or later. Candidates must possess a PhD. or M.D. degree. Applicants using genetic and genomic approaches to understand brain function and dysfunction are encouraged to apply. Candidates combining bioinformatics with wet bench approaches in animal model and/or human studies are encouraged to apply. The appointee is expected to have an active research program, a strong commitment to high quality teaching, the potential to attract extramural funding, and excellent potential for interactions/collaborations with existing faculty at the CNS and in MMG. The applicant’s accomplishments in innovative research and commitments to teaching should demonstrate their potential to develop into the future leaders of their fields. We welcome a broad spectrum of applicants, spanning diverse systems and approaches. The successful candidate will be expected to teach in undergraduate and graduate programs, and should be committed to mentoring and fostering diversity. Candidates will be expected to develop a strong dynamic independent research program and to share our commitment to scholarly undergraduate and graduate education. We prefer applicants with postdoctoral training.

The Department of Neuroscience at the University of Texas Southwestern Medical Center, under the leadership of Dr. Joseph Takahashi, invites applications at the Assistant Professor level for a tenure-track Faculty position in the broadly defined area of molecular neuroscience.

The Departments of Molecular and Cellular Physiology and Neurobiology at Stanford University, in partnership with the new Stanford Center for Molecular Neuroscience in Health and Disease (CMNHD), invite applications for two tenure-track positions as Assistant Professors in molecular neuroscience, broadly defined.In this position, you will enjoy dynamic colleagues and mentors in your academic department and as a member of Stanford’s CMNHD. You may also join the vibrant, multidisciplinary community of neuroscience researchers comprising the Stanford Neuroscience Institute. In this context, you will develop an outstanding neuroscience research program and contribute to the education and mentoring of the next generation of scientists.

The Department of Biological Sciences at Augusta University anticipates a tenure-track position at the rank of Assistant Professor beginning in August 2018. The Department is composed of 22 full-time and 7 part-time faculty members with expertise across a broad spectrum of biological disciplines. We have a strong commitment to providing research opportunities and experience to our undergraduate students in addition to excellent classroom and laboratory instruction. As a thriving unit in this research university, faculty in the Department of Biological Sciences have both the opportunity and the expectation to help develop new undergraduate and graduate programs in the biological sciences. Within the next academic year, we expect to launch our first master’s program in Biomolecular Sciences and the faculty member hired for this position will be an integral part of this emerging program.

Applications are invited for a position at the level of tenure-track Assistant Professor. The Department of Neurobiology and Behavior is ranked as one of the top neuroscience departments in the country and engages in interdisciplinary approaches to the study of neurobiology. The Institute for Memory Impairments and Neurological Disorders is home to one of 31 Alzheimer’s Disease Research Centers funded by the National Institutes of Health. We seek outstanding candidates whose research addresses the molecular neuropathology of Alzheimer’s disease and other neurodegenerative disorders. Preference will be given to applicants whose research integrates cutting edge neuroscientific techniques using human and animal tissue.

The Department of Biological Sciences of Augusta University invites applications for a tenure-track position at the rank of Assistant Professor to begin in August 2019. The Department is composed of 22 full-time and 7 part-time faculty members with expertise across a broad spectrum of biological disciplines. We have a strong commitment to providing research opportunities and experience to our undergraduate students in addition to excellent classroom and laboratory instruction. As a thriving unit in this research university, faculty in the Department of Biological Sciences have both the opportunity and expectation to help develop new undergraduate and graduate programs in the biological sciences. Within the next academic year, we expect to launch our first master’s program in Biomolecular Sciences, and the faculty member hired for this position will be an integral part of this emerging program.

The Virginia Tech Carilion Research Institute (VTCRI) (http://research.vtc.vt.edu) is recruiting several faculty in cellular and molecular neurobiology at the assistant professor level. The faculty will be recruited into two new centers (http://research.vtc.vt.edu/centers/) within the institute – the Developmental and Translational Neurobiology Center and the Glial Biology in Health, Disease, and Cancer Center. The faculty members will have tenure track appointments in an appropriate department and college at Virginia Tech.

Tenure-track Assistant Professor of Biology in Neurobiology of Disease to teach courses in neuroscience, human physiology, anatomy, or cell biology; develop an active research program leading to publications and external funding; advise undergraduate and graduate students; and provide service to the institution.

The McDonnell Center for Cellular & Molecular Neurobiology at Washington University School of Medicine invites applications for tenure track Assistant Professor positions. We are seeking talented investigators who will develop an innovative research program in any field within the area of fundamental and translational neuroimmunology. Investigators employing novel genomics and neurological diseases including, but not limited to neurodegenerative and demyelinating disorders, are encouraged to apply. Investigators will be supported by the McDonnell Center in collaboration with two of our outstanding departments—one preclinical and one clinical—at Washington University School of Medicine. Applicants should submit a cover letter, curriculum vitae, one-page summary of research accomplishments and one-page description of future research plans online.

The McDonnell Center for Cellular & Molecular Neurobiology at Washington University School of Medicine invites applications for tenure track Assistant Professor positions. We are seeking talented investigators who will develop an innovative research program in any field within the area of fundamental and translational neuroimmunology. Investigators employing novel genomics and neurological diseases including, but not limited to neurodegenerative and demyelinating disorders, are encouraged to apply. Investigators will be supported by the McDonnell Center in collaboration with two of our outstanding departments—one preclinical and one clinical—at Washington University School of Medicine. Applicants should submit a cover letter, curriculum vitae, one-page summary of research accomplishments and one-page description of future research plans.

The BARROW NEUROLOGICAL INSTITUTE seeks an exceptionally promising or accomplished investigator to study neuroinflammation and complement other translational neuroscience research in a unique and dynamic environment within the Division of Neurobiology at the Barrow Neurological Institute (https://www.barrowneuro.org/).

To fulfill its mission, QBRI is recruiting independent, full-time Scientists (equivalent to Assistant Professor), Senior Scientists (equivalent to Associate Professor), and Principal Investigators (equivalent to Full Professor) for the Neurological Disorders Research Center, to lead and support basic, clinical and translational research on the genetics of neurodevelopmental and neurodegenerative diseases. Individuals with expertise in drug/biomarkers discovery, functional genomics, computational and systems biology, development of cellular and animal disease models, and neurodevelopment phenotyping are encouraged to apply.

The USC Stevens Neuroimaging and Informatics Institute (INI) seeks highly-qualified applicants for the position of Assistant Professor (tenure-track). The successful applicant will have a minimum 5+ years experience (post doctoral degree) in imaging in aging and neurodegenerative diseases. A particular emphasis on functional and structural connectivity in Alzheimer’s disease is desired. The candidate should have specific interest in mechanistic processes of aging include neuroinflammation, and/or genetics. A strong foundation in understanding the role of imaging, genetics, and clinical phenotypes in characterizing age- and disease-related phenomena is desired. The candidate should have a PhD in Neuroscience, Psychology, or other related disciplines; a strong foundation in neuroimaging and 5+ years post-PhD research experience with a successful publication record and teaching experience is required. The applicant must demonstrate an ability to work with a highly collaborative and multidisciplinary team. Further, the applicant must have demonstrated a strong track record of obtaining independent funding to support a research program.

As part of a multi-year initiative to enhance existing strengths and interests in Neuroscience, the Department of Psychology & Neuroscience (http://www.colorado.edu/psych-neuro/) at the University of Colorado Boulder invites applications for a tenure-track Assistant Professor position to begin Fall 2019. Candidates are expected to develop an active collaborative research program that utilizes innovative and transformative neurotechnologies (e.g., analysis of cell-specific and circuit-specific processes, high-throughput cell-type classification in the brain, pharmaco- or optogenetic methods, related novel technologies). Candidates with specific research interests in the neurobiological mechanisms associated with behavioral resilience and susceptibility relating to affective, motivational, and/or cognitive dimensions are highly encouraged to apply. This position is aimed at strengthening a world-class core of behavioral and molecular neuroscientists focused on understanding the functioning of the nervous system in health and disease. Successful applicants should have an outstanding record of research achievement and are expected to establish an extramurally funded research program and contribute to the undergraduate and graduate education mission of the Department.

In a major Neuroscience initiative, we seek to hire up to 2 tenure-track or tenured faculty members as part of a cross campus multi-disciplinary effort to study the nervous system (from development, to function, to aging, degeneration and repair). We seek researchers that collectively span multi-disciplinary levels of investigation (molecular mechanisms, circuit analysis, complex animal and human behaviors) using state of the art techniques (molecular, optogenetics, behavioral, educational, computational, imaging, EEG, genetic and research of clinical populations) applied to experimental model systems of health, injury and disease (invertebrate, vertebrate or human systems). Our goal is to recruit a team of collaborative individuals with an outstanding record, committed to excellence in research, that complement existing campus strengths. Applicants for tenured positions should also demonstrate notable scientific contributions and sustained extramural support. Successful candidates must also have clear potential or demonstrated ability to work successfully with and benefit a diverse student body.

The College of Sciences at the Georgia Institute of Technology invites applications for a tenure-track faculty position at the assistant professor level in neuroscience. This search represents a critical step in our ongoing, institute-wide initiative in expanding the neuroscience and neuroengineering community at Georgia Tech that has launched a successful undergraduate major and that is developing graduate training in neuroscience. We invite applications from outstanding researchers pursuing innovative questions and cutting edge methodologies aimed preferentially at the cellular or molecular levels, broadly interpreted within a wide range of fields and models of study in neuroscience. The successful candidate will benefit from academic interactions through membership in our interdisciplinary neuroscience community (http://neuro.gatech.edu/), which incorporates science and technology from multiple schools spanning the Colleges of Sciences, Engineering and Computing.

The Program in Neuroscience and Behavior at Mount Holyoke College invites applications for a full-time tenure-track assistant professor in systems neuroscience beginning July 1, 2019. The successful candidate will demonstrate the ability to build a rigorous program of high quality research that integrally involves the contributions of undergraduate students. Research interests across the discipline of neuroscience are welcome and may include vertebrate and invertebrate models, or computational approaches. We also seek candidates with a strong commitment to undergraduate education who will teach 4 courses per year, which may include an introductory course, the development of an intermediate neuroscience course, and upper-level laboratory and seminar courses in the candidate’s area of expertise.

Beginning immediately, we seek investigators who will develop independent and vigorous research programs in any area of pharmacology and chemical biology. Individuals with demonstrated research interests and accomplishments in chemical biology, molecular pharmacology, systems pharmacology, as well as innovative approaches for therapeutic discovery and disease biology are encouraged to apply.

The Department of Pharmacology at the Emory University School of Medicine invites applications for tenure-eligible Assistant Professor positions. Applicants for other ranks will also be considered. Beginning immediately, we seek investigators who will develop independent and vigorous research programs in any area of pharmacology and chemical biology. Individuals with demonstrated research interests and accomplishments in chemical biology, molecular pharmacology, systems pharmacology, as well as innovative approaches for therapeutic discovery and disease biology are encouraged to apply.

The Columbia Stem Cell Initiative (CSCI) at Columbia University in the City of New York is seeking candidates for several tenure track Assistant Professor positions. Applicants must have a Ph.D. and/or M.D. degree and have demonstrated excellent qualifications in research.

The Neurological Clinical Research Institute (NCRI) develops, designs, supports and manages innovative observational and interventional trials for neurological disorders. This fast paced institute has an impressive record of efficiently organizing, overseeing, coordinating, and conducting small and large multi-center, international clinical trials. The mission of the NCRI is to accelerate translational research in neurological disorders through initiating and testing novel therapies. The NCRI also serves as a Coordinating Center for the Northeast ALS Consortium (NEALS), a non-profit, research consortium committed to the cooperative implementation, timely completion, analysis, and reporting of clinical trials and other research studies aimed at improving patient care and understanding of the disease process of Amyotrophic Lateral Sclerosis (ALS).

The candidate should have areas of specialty interest that would mesh well with existing priorities that include cerebrovascular diseases, neurodegenerative diseases, movement disorders, or epilepsy, but candidates with expertise in other areas will also be considered. The ideal candidate will have finished a residency plus a Neurology fellowship. The successful candidate will receive start up funding, dedicated research time to build a world-class research program and have a strong interest in an academic career. This is a tenure track position.

The Department of Developmental Neurobiology at St. Jude Children’s Research Hospital (St. Jude) starts a new phase of hiring that will focus on exceptional and creative scientists for a FACULTY position in neuronal cell biology. We are seeking an investigator to lead a multidisciplinary research program that thematically applies cell biological paradigms and approaches to mechanistically decipher the core cellular mechanisms of neurons in the developing nervous system. Areas of interest include mechanisms underlying genome organization, neuronal motility, axon or dendrite morphogenesis, physiology of neuronal trafficking events, synaptogenesis, cell biology of synaptic transmission, and how these processes occur in live animals or are perturbed in neurodevelopmental disorders. Early career investigators interested in contributing to a culture of excellence at St. Jude are particularly encouraged to apply. This search is also open for mid-career investigators with a strong record of independent research.

The Department of Cellular Biology and Anatomy, Medical College of Georgia, at Augusta University is undergoing an expansion of its research program and is seeking tenure-track faculty at the Assistant or Associate Professor levels. Academic rank will be commensurate with experience. The department is seeking candidates with an interest and expertise in diseases associated with aging. Preferential consideration will be given to investigators with research expertise related to Bone/Musculoskeletal, Renal, Visual or Neurodegenerative diseases, which will complement existing strengths within the department. Augusta University is the home of the only research-oriented, state-supported medical school in Georgia and offers an outstanding interdisciplinary environment. The research infrastructure includes state-of-the-art core facilities for confocal, multi-photon and super-resolution imaging, small animal behavior/imaging, proteomics, genomics including high throughput Illumina sequencing, flow cytometry, and electron microscopy/histology. Candidates at the Assistant Professor level must demonstrate a strong potential for research including obtaining extramural funding. Candidates at the Associate Professor level must possess external funding at the NIH R01 level and demonstrate potential for its continuation. The successful candidate will receive a nationally competitive start-up package, be expected to establish and maintain an extramurally funded research program, and participate in teaching. Applicants should submit a curriculum vitae, a statement of research objectives, a description of teaching interests/experience, and identify at least three individuals as references.

The Department of Developmental Biology (www.devbio.pitt.edu) at the University of Pittsburgh School of Medicine is recruiting an outstanding tenure-track or tenured faculty at the Assistant to Associate Professor level. Candidates should have an innovative research program in the area of developmental neurobiology. The use of mouse, zebrafish, and/or stem cell culture or organoid models (iPSC or ES) with strong translational relevance to neurodevelopmental disorders are particularly encouraged to apply. Successful candidates must hold the PhD, MD, or MD/PhD degrees, and have a strong research program with an outstanding publication record. The successful candidate will be housed in new space at the Rangos Research Center of the Children’s Hospital of Pittsburgh with state of the art core facilities, includingFACS facility, vivarium, rodent behavioral core, small animal imaging facility, and others.

The Department of Neurology of Columbia University invites applications for a tenure-track faculty position at the rank of Assistant or Associate Professor. We seek a neurologist with specialty training in neuromuscular medicine, with particular expertise in the care of patients with amyotrophic lateral sclerosis (ALS). The successful candidate will have a primary affiliation with the Eleanor and Lou Gehrig ALS Center in the Neuromuscular Medicine Division, and will focus on the care of patients with ALS and other neuromuscular disorders, including those seen in the ALS and neuromuscular clinics. In addition to supporting the clinical activities of the ALS Center, the position will expand its basic, translational and/or clinical research program. Candidates with research interests in the genetics and basic biology of motor neuron disease, the development of novel ALS therapeutics, biomarker development or brain imaging are especially encouraged to apply. As a member of the Motor Neuron Center at Columbia, the new clinician-investigator will have the opportunity to interact and collaborate with a diverse group of individuals in basic science and clinical departments within the University. The ideal candidate will have extramural funding for research.

The Department of Pathology at Case Western Reserve University (CWRU) is recruiting a tenured/tenure track Associate or Assistant Professor to expand its vibrant research program in neurodegenerative diseases. Candidates with an established track record in prion research or protein conformational disorders are strongly preferred; the ability to engage in a broader scope of research including other neurodegenerative disorders is also preferred. The Department houses the CDC-funded National Prion Disease Pathology Surveillance Center, has an NIH T32 training grant in neurodegenerative diseases, and already has 10 faculty members engaged in neurodegenerative disease research including prion disease, Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis. The scientific environment is further supported by a strong interdepartmental Neuroscience research community. The Pathology Department is ranked in the top 10 for NIH funding. CWRU is located in Cleveland Ohio, a central Midwestern hub for art, culture, and sports that boasts a low cost of living and outstanding schools.

The Division of Neuropathology in Department of Pathology at Brigham and Women’s Hospital, a teaching affiliate of Harvard Medical School, is seeking an academically oriented, Board-certified Neuropathologist, at the Instructor, Assistant or Associate Professor level, with skills in surgical and autopsy neuropathology. Academic rank and salary will be commensurate with experience and accomplishments. Applicants should be committed to excellent patient care, as well as research, scholarship, and effective teaching. Experience or ability to participate in precision medicine and molecular pathology is preferred. Pathologists with academic focus in neurodegenerative, tumor, medical or any other areas of neuropathology expertise are encouraged to apply. The position will combine clinical duties and academic pursuits (research/teaching) and will be involved in the Longwood Neuropathology Training Program that includes the accredited fellowship program in adult and pediatric surgical and autopsy neuropathology at the Brigham and Women’s Hospital, Dana-Farber Cancer Institute and Children’s Hospital Boston. Candidates would be expected to take advantage of the extensive resources and collaborative interactions within the Brain Tumor Research Program, the Ann Romney Center for Neurologic Diseases, and the Neuroscience Programs of the Harvard Medical School, Dana-Farber Cancer Institute, Brigham and Women’s Hospital, and The Children’s Hospital Boston. Applicants should also have the ability to lead or participate in research in an environment that provides substantial opportunities for clinical/ translational or basic research.

The Albert Einstein College of Medicine (Einstein), together with the Montefiore Medical Center, has launched an ambitious Brain Sciences Initiative. As part of this large-scale expansion, the Dominick P. Purpura Department of Neuroscience has recruited a number of outstanding faculty, and will continue to recruit additional faculty in the coming years.

The Department of Anesthesiology within the Stony Brook School of Medicine seeks to recruit Two outstanding basic scientists and translational scientists at the Assistant Professor level and the Professor/Associate Professor. Current research strengths include: mode of action of anesthetic agents, molecular mechanisms of neurodegenerative disorders, acute and chronic pain, adult neurogenesis, memory and learning, brain imaging, mitochondrial dysfunction, and ciliopathies. These areas are investigated on animal models ranging from Drosophila and frogs to mice and humans. The department also includes strong clinical research. The research arm of the Department has recently undergone major growth, with an expanded focus on basic and clinical neuroscience.

The Department of Neuroscience at UConn Health invites highly motivated investigators addressing key questions in neurodevelopment, synaptic or cognitive dysfunction or neuroinflammation to apply for a tenure-track position at the Assistant or Associate Professor rank. We welcome candidates using the most advanced techniques in mouse genetics, system neurobiology, and electrophysiology. Candidates interested in deciphering disease etiology, molecular mechanisms or carrying out translational studies focused on neurodegenerative diseases, vascular dementia, neuroinflammatory disorders, or neural regeneration will complement the strengths of this department and are particularly encouraged to apply.

The RIKEN Center for Brain Science (CBS) was launched in April 2018 following the strong 20-year foundation of its predecessor, the Brain Science Institute (BSI). CBS aims to meet society’s ever-growing expectations for brain research.

The proposed position is part of a cluster that comprises multiple tenure-track faculty positions, and is designed to establish excellence in emerging interdisciplinary fields; departmental appointments may be in Physics, Biology, Chemistry, Mathematics or Biochemistry. A major goal is to strengthen Cellular and Molecular Neuroscience , as well as to link Neuroscience to the Chemical Biology of Natural Products. All candidates are expected to demonstrate the ability to develop a vigorous, competitive and well-funded research program and will be evaluated on how their research potentially contributes to the long-term goal of excellence in interdisciplinary bridge areas. Applications by investigators, both experimental and theoretical, interested in macromolecular complexes on the membranes of neurons are particularly encouraged. An undergraduate track in Neuroscience and Biophysics is being developed within the College of Science, and faculty hired through this cluster are expected to participate in the development and teaching of innovative courses related to this initiative. While the openings are at the Assistant Professor level, exceptional senior candidates will be considered.

We are seeking individuals with research interests that complement our existing programs related to biological mechanisms and modeling of neurodegenerative diseases. Of particular interest are programs with a focus on Alzheimer’s Disease, Frontotemporal Dementia, and Parkinson’s Disease. Candidates with expertise and documented productivity in research areas that include investigation of how unfolded protein responses contribute to these diseases, with particular focus on tauopathies, are preferred. Candidates must have a desire to expand the educational landscape of the Department of Neuroscience through teaching and research training program development.

The University of New Mexico School of Medicine The Department of Neurosciences invites applications for a tenure-track faculty position at the Assistant or Associate Professor level. Minimum Requirements: Applicants must have a Ph.D. or M.D. degree, or the equivalent and have postdoctoral experience.

The Department of Biology at the University of Massachusetts, Amherst invites applications for a tenure-track position at the rank of Assistant or Associate Professor. The successful candidate will also be a part of the Institute for Applied Life Sciences (see IALS), which has the goals of developing translational research programs, fostering interactions with industry, and training a translational life sciences workforce. New faculty members will be able to take full advantage of the substantial investments in campus infrastructure and core facilities made by IALS (see IALS Cores for details).

Sanford Burnham Prebys Medical Discovery Institute (SBP) is an independent non-profit biomedical research institute that blends world-class fundamental research with drug discovery to address unmet clinical needs in the areas of cancer, neuroscience, immunity, and metabolic disorders. The Institute invests in talent, technology, and partnerships to accelerate the translation of laboratory discoveries that will have the greatest impact on patients. Recognized for its world-class NCI-designated Cancer Center and the Conrad Prebys Center for Chemical Genomics, SBP employs more than 1,100 scientists and staff in La Jolla (San Diego), California, and Lake Nona (Orlando), Florida.

The Department of Neuroscience on the Jupiter, FL campus of The Scripps Research Institute (TSRI) is seeking outstanding applicants for tenure track faculty positions at all levels. We invite applications from ambitious and interactive investigators from all areas of modern neuroscience applying molecular, genetic, biochemical, biophysical, cellular anatomical, and behavioral approaches to elucidate the mechanisms underlying nervous system function and its disorders.

The UTRGV School of Medicine is seeking Faculty members at the Assistant, Associate or Professor level experienced in research in Biomedical Sciences. The background should be in all disciplines of biomedical sciences including endocrine and metabolic diseases (such as diabetes and obesity), neuroscience and neurodegenerative diseases, cancer or oncology research and research in infectious diseases. The selected individuals will carry out high quality research projects and are expected to successfully acquire extramural research support. Laboratory space, competitive salary and start-up packages are available. Postdoctoral research experience in a top-rated research program is preferred.

Indiana University School of Medicine is seeking applications for tenure-track faculty positions at the Assistant/Associate/Full Professor levels in the basic science areas of chemical biology, metabolism and neuroscience. A key part of a Program in Chemical Biology of the School’s Precision Health Initiative (PHI), this search is also aligned with the Department of Biochemistry & Molecular Biology (BIOM), Stark Neuroscience Research Institute (SNRI) and NIH-designated Center for Diabetes and Metabolic Diseases (CDMD). Applications are welcome from all areas of chemical biology, however, applications with a molecular and/or pharmacological research emphasis in areas such as metabolism\insulin resistance\islet biology and neurodegenerative disease states are highly encouraged. A primary appointment for successful applicants may be based in any of these units as appropriate to the credentials and goals of the candidate.

The Department of Medicinal Chemistry at the University of Minnesota invites applications for a tenure-track faculty position at the rank of Assistant, Associate, or Full Professor level. The Department is housed in the College of Pharmacy (CoP), which is ranked #2 in the Nation as a Top Pharmacy School and #3 in research funding among its peers. The position will be a twelve-month full-time appointment, with expectations in teaching (in the areas of Medicinal Chemistry & Neuroscience) and service to both the PharmD professional curriculum and also the Departmental graduate education programs. Candidates are expected to establish, maintain, and direct a major research program addressing chemical neuroscience from a medicinal chemistry/chemical biology perspective to interface with other activities within the University of Minnesota, the CoP, and the Institute for Translational Neuroscience (https://www.med.umn.edu/research/research-strengths-expertise/neuroscience/institute-translational-neuroscience ). Emphasis is placed on research in neurodegenerative disorders, epilepsy, psychiatric diseases, neuroaddiction, and neuroendocrinology, but all neuroscience sub-disciplines are encouraged to apply. Interested candidates are strongly encouraged to apply by December 15, 2016 for the first review; however, this position will remain open until filled.

The Department of Environmental and Occupational Health (EOH) within the Robert Stempel College of Public Health & Social Work (RSCPHSW) at Florida International University (FIU) invites applications for two tenured/tenure-track faculty member at the Assistant/Associate/Professor rank (rank and tenure commensurate with qualifications).

The Department of Molecular Pharmacology and Physiology at the University of South Florida Morsani College of Medicine invites applications for tenure-track faculty positions at the Assistant/Associate/Full Professor levels. A doctoral degree in medical or biomedical sciences is required. Applicants must demonstrate a strong record of academic accomplishments with NIH-supported research programs. Expertise in neuroscience, cardiovascular, splanchnic organ system, metabolism and inflammation/immunology research areas is preferred, with an emphasis on the study of molecular, cellular and systemic mechanisms. Applicants must also demonstrate a history of medical school teaching excellence and are expected to have outstanding verbal communication skills.

The BARROW NEUROLOGICAL INSTITUTE seeks an exceptionally promising or accomplished investigator to complement other translational neuroscience research in a unique and dynamic environment within the Division of Neurobiology at the Barrow Neurological Institute (https://www.barrowneuro.org/). Qualified applicants holding Ph.D., M.D. or equivalent degrees will be considered for appointment at assistant, associate or full professor levels. The successful candidate will be expected to direct an extramurally-funded research program in neurodegenerative disease research using interdisciplinary approaches. Institutional strategic interests for this position are in Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, and traumatic brain injury. Qualified applicants in other areas of translational neuroscience also will be considered. The successful candidate is expected to synergize/collaborate with existing research and clinical faculty, will have access to core facilities and clinical samples, and may leverage opportunities to collaborate with investigators at affiliate institutes including Phoenix Children’s Hospital, the Translational Genomics Research Institute, and the University of Arizona. The successful candidate will receive a highly competitive start-up package and salary support.

We invite applications for a tenure review eligible faculty position at the rank of Assistant, Associate or Full Professor in the Brain and Mind Research Institute and in relevant Graduate Training Programs at Weill Cornell Medicine. Primary criteria for appointment will be outstanding records of innovative research, academic performance and commitment to disease-focused neuroscience. Of particular interest are applicants who are using electrophysiology, imaging, immunology, and computational approaches to unravel mechanisms of major brain disorders such as Alzheimer’s disease and related conditions. Demonstrated ability to attract independent grant support is another selection criterion. Additional requirements include a medical or doctoral degree, and at least four years of teaching experience (during residency, fellowship, and/or in the lab) by the time the appointment becomes effective.

The University of Southern California (USC) Titus Family Department of Clinical Pharmacy invites applications for a tenured/tenure track position at the rank of Assistant, Associate or Professor. Individuals with research interests in pharmacogenomics, pharmacometrics, bioinformatics, or medication safety are encouraged to apply.

The Department of Pathology and Cell Biology at the Columbia University Medical Center seeks highly qualified individuals for faculty positions in surgical pathology, clinical pathology and research. Appointments can be at the Instructor, Assistant, Associate, Professor, or Associate Research Scientist level depending on experience and qualifications. All positions require outstanding academic credentials and a record of scholarly productivity. Clinical positions require board certification and a license in NYS. Columbia University’s Department of Pathology & Cell Biology invites applications for a junior/senior level faculty position. Candidates should have a strong record of research and teaching qualifications (distinction). Candidates will be expected to sustain an active research and publication portfolio and supervise graduate students, and fellows. Candidate will play a vital role in Departmental activities.

The Department of Neurosciences at the University of California San Diego (UCSD) (http://neurosciences.ucsd.edu/) is committed to academic excellence and diversity within the faculty, staff and student body. The Department is currently recruiting for full or part-time faculty positions for clinicians who will participate in clinical practice in an academic setting and for translational research scientists with demonstrated scientific expertise in areas such as neurobiology, epidemiology, neuroimaging, neuropathology, biomarkers, or behavioral neurology/cognitive neurosciences of neurological disorders or related fields.

Employer: Yale University School of MedicineLocation: New Haven, CTSector: AcademiaDegree Required: PhD, MD or MD/PhDConditions: NDGPosted on: August 16, 2018Description:

The Department of Genetics at Yale University School of Medicine is searching for a Professor of Genetics with an outstanding record of transformative scientific achievements in Human Genetics and Genomics. We expect that the candidate will lead a vigorous cross-disciplinary research program focused on identifying and characterizing genetic drivers of human disease. As a leader of human genetics both within the department and across the Yale School of Medicine, the successful candidate will have the opportunity to recruit other human geneticists to the Genetics Department and lead a new program in precision medicine as the Scientific Director of the Yale Center for Personalized Medicine and Genomic Health.

Employer: Voyager TherapeuticsLocation: Cambridge, MASector: IndustryDegree Required: PhD with 8+ years of industry experience in process development, or BS or MS degree with 15+ years of industry experienceConditions: NDGPosted on: September 14, 2018Description:

Voyager is seeking a highly motivated Associate Director/Director to lead Cell Culture Development and Baculovirus Vector Engineering activities for the production of rAAV. Level commensurate with experience.

In conjunction with and reporting to the Sr. Vice President of Business Development, the Senior Manager/Associate Director, Business Development and Alliance Management will focus on building value through strategic alliances and/or licensing transactions.

AveXis, Inc., a Novartis Company, is a clinical-stage gene therapy company, dedicated to developing and commercializing novel treatments for patients suffering from rare and life-threatening neurological genetic diseases. Our initial product candidate, AVXS-101, is our proprietary gene therapy product candidate currently in development for the treatment of spinal muscular atrophy, or SMA, Type 1, the leading genetic cause of infant mortality, and for the treatment of SMA Type 2. The U.S. Food and Drug Administration, or FDA, has granted AVXS-101 Orphan Drug Designation for the treatment of all types of SMA and Breakthrough Therapy Designation, as well as Fast Track Designation for the treatment of SMA Type 1. In addition to developing AVXS-101 to treat SMA Type 1 and Type 2, we also plan to develop other novel treatments for rare neurological diseases, including Rett syndrome (RTT) and a genetic form of amyotrophic lateral sclerosis (ALS) caused by mutations in the superoxide dismutase 1 (SOD1) gene.

The Department of Psychiatry & Behavioral Sciences and the Cognitive Neurology and Alzheimer’s Disease Center at the Northwestern University Feinberg School of Medicine are jointly searching for a cognitive neuroscientist. The successful candidate will have the credentials for a full-time tenure-track appointment (Investigator Track) at the level of Associate Professor. The candidate will have the capability to lead an independent laboratory on the experimental neuropsychology and multimodal imaging of neurodegenerative diseases and successful aging. Established track record of research achievements in these areas and expertise on the cognitive aspects of aging and dementia are desirable. The successful candidate will contribute to the academic mission of the Clinical Psychology Doctoral Program within the Department of Psychiatry and will lead his/her research program on dementia and aging within the Cognitive Neurology and Alzheimer’s Disease Center. The start date is negotiable and the position will remain open until filled.

Amgen is seeking an Associate Scientist to join the Neuroscience Department at our research facility in Cambridge, MA. The Associate Scientist will work independently and as part of cross-disciplinary teams. The Associate Scientist will join an energetic research team responsible for the design and execution of innovative assays and the production of high quality data with the goal of developing therapeutics for neurological disorders with an emphasis on Neurodegenerative Diseases (Parkinson’s disease, Alzheimer’s disease, and Amyotrophic Lateral Sclerosis).

The ALS Therapy Development Institute (ALS TDI) has an opening for a full-time Associate Scientist working in the Translational Research group. The Associate Scientist will be part of the team working to develop patient-derived induced pluripotent stem cell (iPSc) collection, as well as the development and implementation of cell-based high content screens for target and drug discovery.

Yumanity is seeking a talented and versatile BS/MS scientist to join our interdisciplinary team to help advance novel drug discovery programs for neurodegenerative diseases. This position will be laboratory based, and requires strong experimental skills with background in cell and molecular biology and experience in quantitative assay development. The successful candidate must be highly flexible and team-oriented. The position will report to a Principal Scientist in the Mammalian Assay Development group, and will interact across all of Yumanity’s core platforms, including yeast phenotypic screening, target identification, stem cells and chemistry.

Yumanity is seeking an associate scientist to join our interdisciplinary team to help advance our novel drug discovery programs. This position will be laboratory based and requires experimental skills in human stem cell culture, including experience differentiating patient and control-derived progenitor cells into various central nervous system cells. This position will report to a Senior Scientist in Discovery Biology and will collaborate across all of Yumanity’s core platforms, including yeast phenotypic screening, target identification and chemistry.

Yumanity is seeking an associate scientist to join our interdisciplinary team to help advance our novel drug discovery programs. This position will be laboratory based and requires experimental skills in human stem cell culture, including experience differentiating patient and control-derived progenitor cells into various central nervous system cells. This position will report to a Senior Scientist in Discovery Biology and will collaborate across all of Yumanity’s core platforms, including yeast phenotypic screening, target identification and chemistry.

The Department of Neurology Research is seeking a highly talented and enthusiastic associate to join an in vitro / in vivo target discovery and validation effort in Amyotrophic Lateral Sclerosis (ALS) aimed at bringing new targets and therapeutic strategies from discovery to development. The successful candidate will be expected to support efforts to develop and validate new in vitro ALS models for candidate identification and validate findings in primary mouse tissue.

The Neuroimmunology department at Biogen is searching for a committed, enthusiastic and dependable associate scientist to assist with the design, execution and interpretation of preclinical studies for drug discovery and development. The incumbent will be part of a multifunctional team with responsibility for target validation and evaluation of novel drug candidates for neurodegenerative/neuroinflammatory diseases. He/she should be able to plan and execute in vivo and in vitro experiments with high level of independency, organization and scientific rigor. He/she should be able to maintain an up-to-date knowledge of pertinent literature and possess excellent communication and interpersonal skills to efficiently present results to project team members.

The Department of Neurology Research is seeking a highly talented and enthusiastic associate to join an in vitro / in vivo target discovery and validation effort in Amyotrophic Lateral Sclerosis (ALS) aimed at bringing new targets and therapeutic strategies from discovery to development. The successful candidate will be expected to support efforts to develop and validate new in vitro ALS models for candidate identification and validate findings in primary mouse tissue.

The Biogen Department of Neuro/Immunology seeks a highly motivated and keen associate scientist whose primary responsibility is to advance target validation, drug discovery and development. The individual is expected to have mastered a broad range of experimental techniques, preferably having established expertise in the field of neuroimmunology. The individual will be expected to perform with significant independence with respect to designing and executing controlled experiments, analyzing and interpreting results, establishing and executing existing or new protocols/methodologies and recommending modifications. The individual is expected to read pertinent literature and exhibit knowledge of molecular and biological processes, applying their knowledge to propose new ideas and regularly make suggestions for creative solutions to technical challenges. The individual is expected to have strong written and verbal communication skills, preparing and delivering oral presentations, posters, draft research reports and contributing to manuscripts.

The Model Animal Research Center (MARC) of Nanjing University, which focuses on basic and translational medicine research with the achievement published in high profile journals such as Cell, Nature, Neuron, Nature Medicine and their sister series, invites applications for full-time faculty positions, at academic ranks of Associate or Full Professor. Individuals with demonstrated accomplishments in, but not limited to, the following areas are encouraged to apply – 1) Organogenesis and Birth Defect 2) Physiological Homeostasis Control and Metabolic Disease 3) Cancer and Stem Cell Biology 4) Neurobiology and neurodegenerative disease 5) Bioinformatics Specialists. Highly competitive research package will be provided in a stimulating and nurturing research environment: substantial start-up funds from “National Youth 1000-Talent Plan” and Nanjing University “Deng Feng Plan”; excellent laboratory space; and outstanding Vivarium Facility. For more information and to apply visit website: http://www.nicemice.cn

The Department of Pharmacology & Toxicology and the Stark Neurosciences Research Institute (SNRI) at the Indiana University of Medicine in Indianapolis invites applications from outstanding individuals for the Paul Stark Professorship at the Associate or Full Professor level.

The Molecular Imaging Innovations Institute (MI3) in the Department of Radiology at Weill Cornell Medicine is seeking highly motivated applicants to join our institute, which is located in the brand new, state-of-the-art, Belfer Research Building. MI3is committed to becoming an internationally recognized institute of excellence in the discovery and development of new molecular imaging agents, and strategies for use in basic and translational research and clinical care. Scientists will have access to on-site imaging systems for preclinical and human studies including: MRI, PET/CT, PET/MR, SPECT, CT, optical and ultrasound.

The Department of Pathology (http://pathology.ucsd.edu) and the Department of Neurosciences (http://medschool.ucsd.edu/som/neurosciences) at the University of California San Diego is committed to academic excellence and diversity within the faculty, staff, and student body.

In a major Neuroscience initiative, we seek to hire up to 2 tenure-track or tenured faculty members as part of a cross campus multi-disciplinary effort to study the nervous system (from development, to function, to aging, degeneration and repair). We seek researchers that collectively span multi-disciplinary levels of investigation (molecular mechanisms, circuit analysis, complex animal and human behaviors) using state of the art techniques (molecular, optogenetics, behavioral, educational, computational, imaging, EEG, genetic and research of clinical populations) applied to experimental model systems of health, injury and disease (invertebrate, vertebrate or human systems). Our goal is to recruit a team of collaborative individuals with an outstanding record, committed to excellence in research, that complement existing campus strengths. Applicants for tenured positions should also demonstrate notable scientific contributions and sustained extramural support. Successful candidates must also have clear potential or demonstrated ability to work successfully with and benefit a diverse student body.

The Department of Pharmacology & Toxicology and the Stark Neurosciences Research Institute (SNRI) at the Indiana University of Medicine in Indianapolis invites applications from outstanding individuals for the Stark Professorship at the Associate or Full Professor level. A Ph.D. and/or M.D. degree and tenure track faculty experience are required. Preference will be given to individuals with outstanding scholarship in the fields of neuropharmacology and neuroscience. Competitive start-up packages include ample laboratory space and access to exceptional core research facilities. The successful candidate will have a strong record of publications and peer-reviewed funding as a principal investigator in the field of neuropharmacology as it relates to neuroimmunology, translational neuroscience, and neurodegenerative disease. The scientific environment at the School of Medicine, the Department of Pharmacology and Toxicology, and the SNRI is highly interactive and productive with ties on campus to other Basic Science and Clinical Departments, as well as Research Centers and Institutes. Outstanding core facilities are also available. Interested candidates should upload a cover letter, curriculum vitae, description of research goals, with names and contact information for three references at: http://indiana.peopleadmin.com/postings/4337

The Biocuration Scientist is responsible for the ongoing curation of scientific databases and directories that serve the neurodegeneration research community. The databases reflect the breadth of AD research and include information on research models, mutations, biomarkers, therapeutics, and other aspects of research on AD and related disorders. The Biocuration Scientist collaborates with the scientific content manager and other Alzforum staff members to ensure that information is accurate, up to date, and consistent across the website.

We are seeking an interactive and self-motivated Bioinformatician / Computational Biologist to join a team of cell and molecular biologists working on brain pathophysiology. The projects will focus on interrogating and integrating existing and new genetic and epigenetic datasets generated from genetically engineered mouse models as well as primary human samples. This programme of work is based on published/unpublished work from the team. This work will be conducted by Professor Paolo Salomoni whose research interest is nuclear function in regulation of cell fate in normal brain and CNS disease.

The VIB-KU Leuven Center for Brain & Disease Research is located in Leuven, Belgium, and part of VIB and the University of Leuven (KU Leuven). With more than 300 people working in 17 labs, we study the brain in health and disease. Our research focuses on disorders such as Alzheimer’s, Parkinson’s, frontotemporal dementia and amyotrophic lateral sclerosis (ALS), but also basic research questions relating the cellular heterogeneity of the brain, brain wiring and synapse biology. These studies are integrated with immunology and studies on protein aggregation and amyloid toxicity.

A Bioinformatics Staff Scientist position is available at the DZNE in Tübingen within the scientific team “Genome Biology of Neurodegenerative Diseases” led by Prof. Peter Heutink. The research focus of our group is to identify genetic risk factors for neurodegenerative diseases such as Parkinson’s disease, Alzheimer’s disease, Frontal-Temporal Dementia/Motor Neuron Disease, Progressive Supranuclear Palsy and Ataxia in close collaboration with our clinical partners. As partners in the International Parkinson’s Disease Genomics Consortium (IPDGC) (http://pdgenetics.org/), we participate in large scale genetic and genomic studies to identify new genetic risk factors and to characterize the biological consequences of these mutations and risk factors by using automated high-throughput cellular screens combined with genomic and transcriptomic approaches. For further details on the scientific program of the group, please refer to http://www.dzne.de/en/sites/tuebingen/research-groups/heutink.html.

The VIB-KU Leuven Center for Brain & Disease Research is seeking a highly motivated Single Cell Bioinformatics Specialist. You will collaborate with the 17 research groups within the Center and provide essential input on computational biology aspects of their research projects. In this job you will be confronted with exciting research questions in neurobiology and neurodegeneration; and with a broad spectrum of computational challenges and single-cell omics data sets. You will work closely with in the Laboratory of Computational Biology (Stein Aerts Lab) and with the single cell expertise unit (Suresh Poovathingal) and you will be part of an active bioinformatics community in Leuven, allowing daily interactions with colleague bioinformaticians.

The Biotechnology Discovery Research (BioTDR) Lead Generation is looking to fill a position for an experienced researcher to lead a drug discovery group passionate about discovering and enablement of large molecule drugs to combat diseases in the immunology, diabetes, oncology, neurodegenerative and pain areas. Are you a highly skilled scientist who has demonstrated ability to facilitate communication between multidisciplinary teams, coordinating complex cross-functional teams? Are you prepared to lead productive collaborations both within BioTDR, and with therapeutic area partners as well as clinical colleagues so as to identify and develop opportunities for protein therapeutics? You will participate in ongoing research projects as well as initiate new drug discovery research efforts. You should be able to work in an interdisciplinary setting, have detailed understanding of disease pathophysiology and drug hunting experience.

Applications are invited for a motivated and self-driven individual for the position of Biostatistician with the Irish ALS Research Group, hosted in the Trinity Biomedical Sciences Institute’s Academic Unit of Neurology. This project will combine high resolution structural and dynamic imaging of the brain at 3 Tesla and spectral EEG/ EMG with clinical and genomic data to identify sub-clusters of ALS patients.

The UConn School of Medicine is seeking an outstanding neuroscientist at a rank of Associate or Full Professor to become Chair of the Department of Neuroscience. Candidates with nationally recognized accomplishments in research, sustained NIH or extramural funding, and leadership experience are encouraged to apply. Desired areas of expertise include but are not limited to cellular and molecular neuroscience, chronic and neurodegenerative diseases, brain circuitry research, and neurogenesis and regeneration. This position is ideal for an energetic individual with the leadership skills and vision required to foster the health and growth of a department that values academic excellence and collaboration. The departmental faculty excel in a variety of research areas (neuroscience.uchc.edu), lead educational programs in the graduate, medical and dental schools, and provide a stimulating environment for research trainees.

Employer: University of Connecticut School of MedicineLocation: Farmington, CTSector: AcademiaDegree Required: PhD or MD/PhDConditions: NDGPosted on: July 28, 2017Description:

The UConn School of Medicine is seeking an outstanding neuroscientist at a rank of Associate or Full Professor to become Chair of the Department of Neuroscience. Candidates with nationally recognized accomplishments in research, sustained NIH or extramural funding, and leadership experience are encouraged to apply. Desired areas of expertise include but are not limited to cellular and molecular neuroscience, chronic and neurodegenerative diseases, brain circuitry research, and neurogenesis and regeneration. This position is ideal for an energetic individual with the leadership skills and vision required to foster the health and growth of a department that values academic excellence and collaboration. The departmental faculty excel in a variety of research areas

The University of Arizona College of Medicine – Phoenix is seeking an inaugural Chair for its new Department of Translational Neurosciences (TNS). TNS will be a novel medical school department, one that actively bridges basic science and clinical medicine through innovative collaborative research programs. The Chair will have the opportunity to create the overarching vision and, through strategic leadership, to build a center of translational neuroscience excellence. The Department Chair will have resources to recruit TNS faculty who will enhance our University of Arizona Health Sciences (UAHS) scientific community. We seek a visionary leader with expertise in molecular, cellular, or genetic approaches to neuroscience whose research is motivated by the challenges of nervous system disorders and directed toward advancing clinical care and improving human health in the foreseeable future.

Employer: Florida State University College of MedicineLocation: Tallahassee, FloridaSector: AcademiaDegree Required: PhD or MDConditions: NDGPosted on: November 16, 2017Description:

The College of Medicine at Florida State University has embarked on a strategic effort to increase basic and translational research in human neuroscience. In an effort to extend our impact in neural health, we are seeking applications for the College of Medicine’s Mina Jo Powell Chair in Neurological Sciences.

VA Puget Sound Health Care System (VAPSHCS), located in Seattle, Washington, and the University of Washington (UW) are recruiting for a Physician to serve as their Chief of Staff to provide administrative, programmatic, and clinical leadership for the medical center.

The Neuropsychology Section in the Department of Neurology at the Indiana University School of Medicine and Indiana University Health Physicians has an immediate opening for an Adult Neuropsychologist at the rank of Clinical Assistant Professor. The Section of Neuropsychology is situated in new space inside a unique, integrated clinical neuroscience center of excellence, comprising neurology, psychiatry, neurosurgery, and related services. Responsibilities will include coordination and provision of clinical assessment services, participation in multidisciplinary treatment teams, supervision of pre- and postdoctoral trainees and staff, and participation in the overall academic mission (including lectures to neurology residents). Major patient populations include neurodegenerative diseases, movement disorders, epilepsy, oncology, and brain injury, as well as a broad range of complex medical disorders. Although primarily a clinical position, there are significant opportunities for participation in research, including brain imaging work in alcoholism risk, Alzheimer disease, stroke, epilepsy, etc. Requirements include post-doctoral training in clinical neuropsychology and eligibility for licensure in Indiana. Preference will be given to ABPP-eligible or already board certified clinicians experienced with the above patient populations. Applications will be considered until the position is filled. Indiana University is an EEO/AA Employer, M/F/D. Qualified candidates should submit a letter of career goals and interests and a current CV to: http://indiana.peopleadmin.com/postings/5050

Cognitive Neuroscience at the University of Nebraska Medical Center. The Department of Neurological Sciences at the University of Nebraska Medical Center invites applications for a tenure leading faculty position in Clinical Cognitive Neuroscience. This position is part of a new Neuroimaging Section within the department and aims to leverage multiple hires across the School of Medicine in human neuroscience. We welcome applications from any area of cognitive neuroscience, including memory, executive function, visual attention, perception, audition, motor control, emotion, and decision-making. Methodological specialty within neuroimaging is open, but ideally the candidate would benefit from our strong existing program in MEG imaging, and develop a translational, theory-based multimodal neuroimaging program focusing on their area of interest. The successful applicant would join a growing group of cognitive neuroscientists within the department (and across campus) using MEG, fMRI, and other modalities, and hopefully help grow other programs in parallel with building their own.

The Division of Neuromuscular Disorders is seeking a Research Support Coordinator to join a very active clinical research program with multiple ongoing research studies. The primary focus of the work will be on investigator-initiated research in the fields of amyotrophic lateral sclerosis (ALS) and myasthenia gravis (MG). The research support coordinator will work closely with clinical research coordinators, data manager, statistician, clinical staff and the principal investigator.

We are seeking a Clinical Psychologist with a strong interest in neuroscience and experience in neuropsychological assessment to join a well-established multidisciplinary neuroscience team specialising in early onset and/or rare dementias.

Cedars-Sinai Department of Neurology neuromuscular group is looking for an experienced Clinical Research Coordinator to join their research team. We are currently recruiting for over 10 protocols which include repositories, natural history studies, and interventional trials including pharmacological and surgical approaches.

The University of Miami’s Division of Neuromuscular Disorders in the Department of Neurology is seeking a full time Clinical Research Coordinator. The primary focus of the work will be on investigator-initiated research in the fields of amyotrophic lateral sclerosis (ALS) and myasthenia gravis (MG). To effectively perform in this position, the Clinical Research Coordinator will ideally have experience working on investigator-initiated clinical research projects, to be able to work independently with minimal supervision and to function effectively as part of a team.

We now offer a unique opportunity to an academic clinical neurologist to join our team as a Clinical Research Fellow in Neuromuscular Diseases. During a negotiable 1-2 year commitment based at Cytokinetics’ offices in South San Francisco, the Fellow will contribute invaluable expertise to our clinical development programs in neuromuscular diseases. The Fellow will benefit from an experience rarely available in a strictly academic position; i.e., the day-to-day leadership and management of a clinical trial aimed at the development of new therapeutics for patients. The Fellow may engage in this opportunity in the context of their academic fellowship as a means to satisfy a research requirement if agreeable to their institution. Continued involvement in the clinical management of patients during the period of this fellowship will be encouraged. The Fellow may return to his or her academic post at the conclusion of the term, enriched by this experience in addition to returning to the parent institution with a portfolio of valuable clinical research competencies.

We are looking for an enthusiastic, self-motivated, hands-on scientist who is capable of performing multiple duties inherent in clinical development and comfortable working in an open environment. The clinical scientist will be an integral member of the clinical team and support programs both in the clinic and preparing to enter the clinic. This person will provide cross-functional support to programs by working closely the Medical, Operational, Regulatory, Biomarker, and Technical groups. Successful applicants are expected to function with a high degree of independence in a fast-paced start-up environment while also working collaboratively within a multidisciplinary team that is dedicated to the development of new therapies for neurodegenerative diseases.

The Cognitive Clinical Research Nurse is responsible to promote organizational values of patient and visitor satisfaction by demonstrating courtesy and respect for families, visitors and other employees. Cares for patients in all age groups from young adult through geriatrics. Demonstrates competence in the assessment, treatment and care of patients serviced. Works in collaborative practice setting with supervising/collaborating physicians to care for patients within the Penn Frontotemporal Degeneration Center.

Verge Genomics is looking for a genomics scientist to develop algorithms, statistical methods, and software to analyze large-scale gene expression and genomic datasets. You will implement these methods to identify new disease targets and mechanisms, and drugs that target these disease gene networks. As one of the first employees at Verge, you will develop cutting-edge methods that will serve as the foundation of a revolutionary drug development model.

At Alector, we believe that neurodegeneration and dementia, are in fact immune disorders and we made it our mission to empower the immune system to cure Alzheimer’s disease, frontotemporal dementia, ALS and other degenerative brain conditions. We are supported by leading investors in healthcare including Orbimed, Polaris, Google Ventures and count some of the most innovative pharma companies as our strategic backers.

Alector is looking for exceptional scientists, senior scientists, and director-level investigators with a PhD and/or MD, an outstanding publication and track record, and a drive to innovate. The candidate must have extensive, hands-on expertise in conducting and managing disease model studies for neuro-degeneration and dementia, including Alzheimer’s disease, Parkinson’s disease, Frontotemporal dementia and ALS, in rodents. The successful candidates will play leading roles in the discovery and development of novel, disease-modifying drugs.

We are currently on the hunt for a Director of Research– Neurodegenerative to oversee all aspects of neurodegenerative gene therapy research at the GTP at PENN. In this role, you will be responsible for build a team of Senior Research Investigators (SRI) to support GTP’s Neurodegenerative research efforts; establishing processes for mentoring and leading SRIs in research projects; directly oversee and manage a team of SRIs and technicians; In consultation with the PI of the GTP, the Research Director – Neurodegenerative will assess the rare disease programs that are brought into GTP for scientific research. The individual should have in-vivo pharmacology expertise for preclinical translational programs as well as expertise in testing the efficacy of therapeutic interventions for neurodegenerative disease indications. Joining GTP offers scientific professionals the unique opportunity of seeing their research go from bench to bedside and discoveries that could one day lead to cures.

The Director/Senior Director is a recognized expert in the science and applications of gene transfer and gene therapy. The incumbent will lead the Gene Transfer Technologies research group whose mission is to:

Voyager is seeking a highly motivated scientist and leader with extensive experience in therapeutic antibody discovery and development to contribute to our research team and build the Antibody Platform at the company.

Voyager is seeking a highly motivated scientist and leader with extensive experience in therapeutic antibody discovery and development to contribute to our research team and build the Antibody Platform at the company.

The University of Maryland Department of Neurology is seeking a senior level physician scientist with expertise in dementia and neurodegeneration to serve as the Director of the Center for Neurodegenerative Disorders. Specifically, the Department is seeking an investigator with a strong history of external funding whose work focuses on the molecular and cellular pathogenesis of neurodegenerative disorders including Alzheimer’s disease (AD), Huntington’s disease (HD), Fronto-temporal dementia (FTD), or hereditary ataxias (HA).

The University of Maryland Department of Neurology is seeking a senior level physician scientist with expertise in dementia and neurodegeneration to serve as the Director of the Center for Neurodegenerative Disorders. Specifically, the Department is seeking an investigator with a strong history of external funding whose work focuses on the molecular and cellular pathogenesis of neurodegenerative disorders including Alzheimer’s disease (AD), Huntington’s disease (HD), Fronto-temporal dementia (FTD), or hereditary ataxias (HA).

Reporting to the EVP Research & Development, the Director, Clinical Pharmacology will be responsible principally for early clinical drug development activities with a strong focus on Phase I and Phase IIa clinical trials. He/She will work closely with the Clinical Research Group and other members of the R&D team to ensure a strategic view is taken for the pipeline progression of individual projects.

The National Institute of Neurological Disorders and Stroke (NINDS) seeks a Director to lead its extramural Division of Neuroscience. The Director of the Division of Neuroscience will be responsible for planning and directing a program of extramural and collaborative research in neuroscience, guiding NINDS’s largest research portfolio and charting the future of a vibrant, growing neuroscience research community https://www.ninds.nih.gov/. The Director of the Division of Neuroscience will lead a group of approximately 60 professional staff. The research portfolio of the Division of Neuroscience includes an annual budget of over $1 billion dollars in grants and over $30 million in R&D contracts.

Helsinki Institute of Life Science HiLIFE of the University of Helsinki is seeking a Director of the Institute of Biotechnology (bi.helsinki.fi). The Institute of Biotechnology (BI) is at the forefront of molecular biology research with eight current ERC grantees, and has a strong focus in biotechnology through developing new strategies e.g. to combat neurodegenerative and metabolic diseases. Current research programs at the BI are in Cell and Molecular Biology, Developmental Biology, Genome Biology, and Structural Biology and Biophysics. BI is an international, competitive and rewarding workplace, where the staff within the 25 research groups and 7 core facilities exceeds 250 and comes from 30 different countries. As of 2017 the Institute of Biotechnology is a unit of HiLIFE (www.helsinki.fi/hilife) and collaborates locally across life science units and organizations.

Verge Genomics is seeking a motivated and accomplished Director of Neurobiology with experience using in vivo pharmacology models to translate in vitro compound hits to optimized drug leads. You will lead in vivo studies to validate small molecule efficacy and minimize side effect potentials and establish proof of concept by the manipulation of gene targets to ameliorate or create disease models. The ideal candidate will apply a combination of his or her expertise in the etiology and treatment of ALS, Parkinson’s and Alzheimer’s disease, results from our cell-based screens, and animal studies you will lead to best apply gene networks to guide our drug discovery efforts. With knowledge of neuropharmacology and experience translating compound discoveries to CNS applications, this position offers the opportunity to help lead the neurobiology research program at an emerging biotech company.

The Cleveland Clinic Department of Neurosciences and Neurological Institute are actively seeking a Director to head the Cleveland Clinic Neurodegenerative Disease Research Center. The Director will have the opportunity to lead, expand, and integrate basic, translational, and clinical research programs. Senior candidates with PhD and/or MD degrees and well-established, independently-funded research programs are encouraged to apply. The Department of Neurosciences, the Lerner Research Institute, and the Neurological Institute offer excellent research and core facilities, generous start-up funds, and ongoing operational support. Candidates should submit a curriculum vitae and a brief statement of research interests and vision for the Center via e-mail to [email protected]

The Neuropharmacology Research group is seeking independent and motivated scientists to join a newly established research team focused on the rapid progression of novel therapeutics to humans for neurodegenerative, neurobehavioral and neuromuscular diseases. The Director, Neuropharmacology will be responsible for establishing and leading a research pharmacology group responsible for developing and leading innovative approaches to the treatment of neurodegenerative, neurobehavioral and neuromuscular disorders. The candidate will be expected to lead their own research project, as well as oversee other drug development programs with the goal of building a robust and sustainable portfolio of candidates for clinical development. The candidate will also oversee the efforts and be responsible for guiding the career development of 6-10 scientists.

The Neuropharmacology Research group is seeking independent and motivated scientists to join a newly established research team focused on the rapid progression of novel therapeutics to humans for neurodegenerative, neurobehavioral and neuromuscular diseases. The Director, Neuropharmacology will be responsible for establishing and leading a research pharmacology group responsible for developing and leading innovative approaches to the treatment of neurodegenerative, neurobehavioral and neuromuscular disorders. The candidate will be expected to lead their own research project, as well as oversee other drug development programs with the goal of building a robust and sustainable portfolio of candidates for clinical development. The candidate will also oversee the efforts and be responsible for guiding the career development of 6-10 scientists.

Verge Genomics is seeking a motivated and highly accomplished “drug hunter,” responsible for directing, managing, and leading basic research and drug discovery efforts for neurodegenerative diseases and leading multidisciplinary project teams. This position offers the opportunity to grow and lead a drug discovery program at an emerging biotech from the ground up, while establishing important external partnerships. As a member of the early team at Verge, you will be deeply involved in key strategic decisions and in organization of the research & discovery team, and help build the foundation of a revolutionary drug development model.

The Registry Operations Director will direct and manage operations for MDA’s large, multi-disease Neuromuscular Observational Research (MOVR) Data Hub, a key element of MDA’s mission to improve patient outcomes and help drive drug development. This position works across multiple departments within MDA and with external stakeholders including, but not limited to, industry, governmental agencies, academic institutions and other non-profit organizations to build and maintain the MOVR Data Hub. This position will report directly to the SVP, Scientific Program Director.

Amgen is a leading global biotechnology company, with a mission to serve patients around the world. As a science-based, patient-focused organization, we discover and develop innovative therapies to treat serious illnesses. Our medicines have made a dramatic difference in the lives of millions. To underpin our commitment to serve patients, Amgen is hiring a Director, Research in our Neuroscience group at our Research and Development facility in Cambridge MA (AMA).

We are currently seeking a new Medical Science Liason (Director of Therapeutic Development) to oversee the Program of Excellence focused on Lysosomal Storage, Neurodegenerative, Liver Metabolics, or Infantile Epilepsy diseases/disorders.

We are looking for a talented leader to direct preclinical research in Dementia and Memory Disorders within the new Neurodegeneration and Repair Research Unit. In close partnership with the early clinical lead for within the same unit, the successful candidate will be responsible for delivering innovative drug candidates for proof-of-concept trials in AD, FTD and other memory disorders. He/she will lead the efforts of multiple research teams from early target discovery to late preclinical development and support the clinical trial strategy. We seek a candidate with knowledge of the biology of neurodegeneration and an outstanding track record in the field of drug development. He/she will succeed by collaborating closely with other Biogen scientists and clinicians in the areas of neurodegeneration, neuroimmunology and repair, as well as experts in the multiple therapeutic modalities – small molecules, antibodies, biologics, antisense oligonucleotides and gene therapy – in the Biogen portfolio. An innovative approach to biomarker and drug delivery strategies will also be required. We particularly seek candidates who have demonstrated strong scientific rigor while exploring novel pathways and mechanisms in humans and model systems and in leading multidisciplinary research teams. Demonstrated expertise in Alzheimer’s research and experimental models would be an advantage but is not required.

We are looking for a talented leader to direct preclinical research in Dementia and Memory Disorders within the new Neurodegeneration and Repair Research Unit. In close partnership with the early clinical lead for within the same unit, the successful candidate will be responsible for delivering innovative drug candidates for proof-of-concept trials in AD, FTD and other memory disorders. He/she will lead the efforts of multiple research teams from early target discovery to late preclinical development and support the clinical trial strategy. We seek a candidate with knowledge of the biology of neurodegeneration and an outstanding track record in the field of drug development. He/she will succeed by collaborating closely with other Biogen scientists and clinicians in the areas of neurodegeneration, neuroimmunology and repair, as well as experts in the multiple therapeutic modalities – small molecules, antibodies, biologics, antisense oligonucleotides and gene therapy – in the Biogen portfolio. An innovative approach to biomarker and drug delivery strategies will also be required. We particularly seek candidates who have demonstrated strong scientific rigor while exploring novel pathways and mechanisms in humans and model systems and in leading multidisciplinary research teams. Demonstrated expertise in Alzheimer’s research and experimental models would be an advantage but is not required.

The Musculoskeletal disease area research department at the Novartis Institutes for BioMedical Research (NIBR) in Basel, Switzerland, is looking for a Scientific Associate with excellent electrophysiology skills to join a highly motivated research team that aims to identify and develop therapies for neuromuscular diseases and peripheral neuropathies like amyotrophic lateral sclerosis and sarcopenia.

The Epidemiologist I serves as the Registry Coordinator for the Massachusetts statewide registry of amyotrophic lateral sclerosis (ALS). Responsibilities include those related to the day-to-day operation of the Registry, including contact with all patient reporting sources to ensure complete case ascertainment, oversight of data abstraction and data verification activities, data entry of all clinical files received, and the oversight of all electronic and paper Registry files.

Serves as Registry Coordinator for the Massachusetts statewide registry of amyotrophic lateral sclerosis (ALS). Responsibilities include those related to the day-to-day operation of the Registry, including contact with all patient reporting sources to ensure complete case ascertainment, oversight of data abstraction and data verification activities, data entry of all clinical files received, and the management of all electronic and paper Registry files. This position is also responsible for maintaining a clean and accurate Registry database, conducting statistical analyses on program evaluation and ALS epidemiology in Massachusetts, assisting in the preparation of statistical reports, attending public meetings, and working with other technical staff on special studies. Other duties will include organizing annual advisory committee meetings and collaborating with other Bureau of Environmental Health (BEH) staff in the design and implementation of other environmentally-related chronic disease surveillance systems.

The Rare Disease Research Unit is looking for a talented senior physician scientist to join our team developing transformational new treatments in rare Neuromuscular, Neurodevelopmental and Neurodegenerative diseases using AAV gene therapy. This individual will focus on the challenging translational, clinical and regulatory problems presented by gene therapy in rare (often) pediatric indications, including natural history studies, novel endpoint development and clinical trial design. The candidate will be accountable for the delivery of translational and clinical development plans for AAV gene therapy programs in multiple rare neurological indications, and will be skilled in early clinical program design and conduct from pre-clinical stages to POC. Similar activities will be required for programs exploiting other treatment modalities. Experience and proven collaborative skills with basic and clinical scientists, investigators, regulators and safety functions are essential.

The Los Angeles Biomedical Research Institute at Harbor – UCLA Medical Center (LA BioMed) invites applications from highly accomplished individuals with an MD, PhD, or equivalent degree, at an early career stage with at least three years of postdoctoral training or, as an established mid-career level investigator.

The University of Delaware is seeking applications for several open rank tenure-track professorships as part of a multiyear hiring effort in the area of biopharmaceutical discovery. Applicants must have a doctoral or equivalent degree, documented evidence of high quality research productivity, and a strong commitment to both research and teaching. Applicants with research interests broadly relevant to biopharmaceutical discovery that span chemistry (e.g. chemoproteomics, molecular probes for biological imaging, metabolomics); biology (e.g. diseases of immune or tissue dysfunction) and engineering (e.g. synthetic biology, protein design, metabolic engineering) will be considered. Successful applicants could have faculty appointments in one or more of several departments, including Chemistry and Biochemistry, Biological Sciences, Chemical and Biomolecular Engineering, and Psychological and Brain Sciences.

Outstanding opportunities for faculty scientists at the assistant, associate and professor level exist in our new Center for Neural Science and Medicine (CNSM) at Cedars-Sinai Medical Center. Under the direction of Dr. Robert Baloh, MD, PhD, the Center brings together neuroscientists from across a range of departments and disciplines to facilitate collaborative efforts to improve our understanding of the nervous system. https://www.cedars-sinai.edu/Research/Research-Areas/Neural-Science-and-Medicine-Center/.

The Center for NeuroGenetics at the University of Florida (UF) College of Medicine invites applications for TWO tenure/tenure-track positions at the ASSISTANT, ASSOCIATE or FULL PROFESSOR level. We seek outstanding investigators in the following areas: 1) Neuroscience, neurological disease mechanisms and/or therapeutic development with an emphasis on genetic, computational or pathophysiological disease models; 2) RNA biochemistry with a current or future focus on central nervous system function and disease. The Center has active research programs in human, mouse, and Drosophila genetics together with expertise in gene discovery, RNA biochemistry, structural biology, protein biochemistry, genome editing and computational biology, and is housed in the University of Florida Genetics Institute with contemporary facilities for bioinformatics, genomics and proteomics. In addition to being an active member of the Center, the primary academic appointment will be in a relevant department (e.g., Departments of Molecular Genetics and Microbiology, Biochemistry and Molecular Biology, Neurology, Neuroscience or Pharmacology and Therapeutics).

The University of Central Florida (UCF) has established several interdisciplinary teams of faculty as part of a strategic plan that encompasses our research, academic and service missions. The Disability, Aging and Technology (DAT) cluster was created as a partnership among seven UCF colleges/units (the Colleges of Health and Public Affairs, Nursing, Sciences, Engineering and Computer Science, Hospitality Management, Medicine and the Nanoscience Technology Center). The cluster’s goal is transdisciplinary engagement in research and education to link health and wellness interventions with technology applications so that effective and feasible health, behavioral health interventions, and assistive technologies can be used with diverse populations. In support of this effort, we are recruiting a physician scientist in the Department of Internal Medicine faculty who will serve in the two roles of practicing clinical geriatrician and independent principal investigator in the broad areas of disability, aging, and technology research.

As part of its Neuroscience Initiative, WPI invites applications for an open rank tenured or tenure-track position in Neurobiology in the Department of Biology and Biotechnology to begin in the fall of 2019.

The Centre for Brain Research (CBR), an autonomous centre of Indian Institute of Science, invites applications for the position of faculty. CBR is dedicated to finding early diagnoses and rational therapies for neurodegenerative diseases through better understanding of brain function. CBR fosters inter-disciplinary neuroscience research and is currently recruiting neuroscientists, clinicians, engineers and computational scientists, who would work together to reduce the burden of dementia and other neurodegenerative disorders.Candidates with experience in cognitive neuroscience, epidemiology, brain imaging, computer science and genetics are encouraged to apply.

The Department of Pathology and Laboratory Medicine at the University of California (UC) Davis, School of Medicine is seeking a dynamic academic physician-investigator for a full-time position in the Assistant/Associate/Professor, Regular/In Residence (50%/50%) series, to provide clinical service and teaching in neuropathology, and who can develop an independent hypothesis-based research program in an area of neuroscience, such as Alzheimer’s disease or other neurodegenerative conditions, autism/neurodevelopmental disorders, neoplastic neuropathology. The expectation is that the candidate will spend approximately 30-50% clinical service and teaching and 50-70% research. Clinical duties will focus on surgical and autopsy neuropathology, though other subspecialty areas of anatomic pathology also could be considered based on the candidate’s training and interests. Teaching duties may include clinical, didactic, laboratory and small group teaching of housestaff, medical students, graduate students, and students in other health professional programs, and participation in interdisciplinary clinical conferences.

he Department of Pharmacology and Toxicology invites applications for two new tenure-track positions at the Assistant Professor to full Professor levels. Candidates must hold Ph.D. and/or M.D. degrees; will be expected to develop an extramurally funded research program; and will be expected to participate in our graduate and teaching program in the area of neuropharmacology. Preference will be given to those applicants with active extramural funding and research interests in the development of new treatments for dementia, neurodegenerative diseases and stroke. Successful candidates may qualify for space and a joint appointment in a newly formed Neuroscience Institute that occupies space in a new research building. Serious consideration will be given to outstanding applicants from other areas that are complementary to the department’s current research efforts in cardiovascular, cell signaling, renal and cancer drug development. Information about the Department of Pharmacology and Toxicology is available at http://pharmacology.umc.edu. Review of applications will begin in November 2018 and will continue until the positions are filled. Send Curriculum Vitae and contact information for three references to: Chair of the Search Committee, Department of Pharmacology, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216-4505 or email [email protected] EOE, M/F/D/V.

The Department of Cell Biology and Physiology and the Neuroscience Center at the University of North Carolina at Chapel Hill invite applications for two open-rank, tenure-track/tenure eligible faculty positions. Research areas of particular interest include Alzheimer’s disease, neurodegeneration, pain, glial biology and glial diseases, but outstanding work in any area of neuroscience will be considered.

Virginia Tech (VT) recently launched a bold and innovative Neuroscience Initiative by establishing a School of Neuroscience. Virginia Tech invites applications for tenure track faculty positions in the School of Neuroscience at the assistant-, associate- or full-professor level. We are seeking candidates that will apply innovative approaches to all aspects of cellular, molecular and computational neuroscience that will complement the expertise of the 15 primary faculty members who have joined the School of Neuroscience since 2015 (http://www.neuroscience.vt.edu). Successful candidates will establish a competitive research program that can attract extramural funding from a wide variety of funding agencies. Competitive salary, space, and start-up packages will be provided and be commensurate with experience.

The Centre de Medicina Regenerativa de Barcelona (CMRB) is seeking to recruit three new Independent Group Leaders at junior or midcareer level to complement and extend our existing programs. Areas of specific interest for the current call include, but are not limited to: cell replacement therapies for (i) heart failure, (ii) non-malignant hematological diseases, and iii) age-related macular degeneration; and iv) iPSC-based modeling of neurodegenerative diseases.

St. Joseph’s Hospital and Medical Center and the Barrow Neurological Institute® (BNI) have consistently been recognized for clinical and research excellence in an academic medical center setting and for the high quality of patient and employee experiences in the organizations. Laboratory-based research and patient-oriented clinical studies have international stature and often involve extensive collaborations with academic and industry partners regionally, nationally and globally. There are educational experiences at secondary school, undergraduate, graduate and post-graduate levels. Administrative functions ensure that there is safe, ethical and responsible conduct of research and facilitate research management and interfaces with other units in the Hospital and Institute. Opportunities exist to become part of this unique and dynamic enterprise.

The Department of Neuroscience at Mayo Clinic in Jacksonville, FL, is seeking outstanding candidates with dynamic research programs in neurobiology of disease and aging. The ideal candidate for this position will be an investigator with an innovative and dynamic research program that is directed at understanding the fundamental role of disease biology in neurodegenerative disease including Alzheimer’s disease, Parkinson’s disease, Frontotemporal dementia, and Amyotrophic Lateral Sclerosis. Specific areas of interest include cerebrovascular disease, CNS immunity, neurobiology of aging, stem cell biology, neurodegeneration and neuroregeneration across a range of neurological disorders. We are seeking a world-class researcher to participate in departmental and institutional initiatives emphasizing collaboration and team science.

The BARROW NEUROLOGICAL INSTITUTE seeks an exceptionally promising or accomplished investigator to study neuroinflammation and complement other translational neuroscience research in a unique and dynamic environment within the Division of Neurobiology at the Barrow Neurological Institute (https://www.barrowneuro.org/).

Curtin University is seeking to appoint an Associate Professor/Professor, to further strengthen Western Australia’s research on neurological disorders and neuroscience, at the soon to be completed Sarich Neuroscience Research Institute building. You will take a leadership role in fostering translational research and links with industry and community groups.

The Perelman School of Medicine at the University of Pennsylvania seeks candidates for an Assistant or Associate Professor position in the tenure track. The successful applicant will have experience in the field of Computational & Systems Biology with a focus on neurodegenerative diseases, including modeling cellular and molecular interactions and pathways, use of model organisms for generating human disease oriented leads, analysis of large genomic and phenotype data sets, and personalized medicine for central nervous system disorders.

The Department of Anatomy and Neurobiology at the University of Tennessee Health Science Center seeks an outstanding researcher in the area of neuroinflammation and neurodegeneration to fill an open rank tenure-track position. We seek candidates to complement and extend departmental and campus-wide research on the role of microglia/neuroinflammation in neurodegenerative diseases, especially, but not limited to, traumatic brain injury, chronic traumatic encephalopathy, stroke, Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis.

The Oklahoma Medical Research Foundation (OMRF) is seeking established investigators to maintain a research program that addresses issues relevant to mechanisms of sarcopenia and frailty, neuromuscular junction maintenance, aspects of age-related changes in muscle physiology, or mechanisms of age-related neurodegeneration. Candidates with significant knowledge of diseases of neuromuscular degeneration, such as ALS, are of special interest.

The University of Illinois at Chicago, College of Pharmacy, Department of Biopharmaceutical Sciences (http://go.uic.edu/BPS) invites applications for an open rank tenure-track faculty position in the field of pharmaceutics, drug delivery, or therapeutic bioengineering. Of particular interest are candidates with training and research interests in the areas of biologics, biopharmaceutical processing, formulation, and delivery. Special attention will be given to candidates whose research complements and expands our research in the areas of cancer, neurodegenerative diseases and/or the human microbiome.

Applications are invited for a position at the level of full professor. The Department of Neurobiology and Behavior is ranked as one of the top neuroscience departments in the country and engages in interdisciplinary approaches to the study of neurobiology. We seek outstanding candidates whose research addresses neuroimmunology with application to human neurological disease using multiple approaches including model systems. Areas may include neuroinflammatory responses due to viral infection of the CNS, the role of the immune system in demyelinating diseases such as Multiple Sclerosis, or in other neurodegenerative diseases. Applicants should hold a Ph.D., M.D., or equivalent degree and have an international reputation with an impactful, collaborative and well-funded research program. Desire to contribute to both teaching and mentorship at the undergraduate and graduate level and participate in leadership and mentoring at UCI and within their field is required. Please submit by December 15, 2018, curriculum vitae, a description of research and teaching interests, and the names and addresses of three potential referees. A separate statement that addresses past and/or potential contributions to diversity, equity and inclusion should also be included in the application materials. For application instructions, please go to the Department of Neurobiology and Behavior Professor section at https://recruit.ap.uci.edu/apply/JPF05003. Information on the department is available at http://neurobiology.uci.edu.

Working in the Neurological Clinical Research Institute (NCRI) at Massachusetts General Hospital (MGH) the genetic counselor will collaborate with and support the Amyotrophic Lateral Sclerosis (ALS) multidisciplinary clinical research team. The incumbent must have prior genetic counseling experience and a desire to be a key component of a team working to define the field of ALS genetics research. The majority of work will remain in the research realm; however, there will be opportunity to assist with complex ALS cases within the MGH ALS Multidisciplinary clinic or MGH Brain Health Clinic.

The laboratory is seeking a motivated Graduate Research Assistant to join our efforts in exploring disease mechanisms and developing therapeutic strategies for amyotrophic lateral sclerosis (ALS) and dementia. There is an increased focus on altered RNA processing as a central component of neurodegeneration in ALS and frontotemporal dementia. Our group explores the role of RNA alterations in neuronal death and uses splicing and expression profiles to identify therapeutic strategies that correct disease-linked gene expression events. The successful candidate will lead a research project using various cellular and animal models of ALS to explore disease mechanisms. Under the supervision of the Principal Investigator, the candidate will design and perform experiments, will participate to the scientific lab meetings and is expected to fully participate in the organization and joint upkeep of the laboratory. He/She will perform laboratory experiments which include DNA and RNA purification, quantitative PCR, gel electrophoresis, Western blots, DNA cloning, immunostaining, preparation of libraries for high throughput sequencing, and mammalian cell cultures. Experience in mouse handling and mouse histology is preferred. The individual must pay attention to details, be capable of working independently under minimal supervision, possess good verbal and written communication skills, and work well as part of a team.

The project will focus on the composition and biological impact of protein aggregates in ALS throughout the evolution of the disease and among the different types of the disease (e.g. C9ORF72-related ALS). To identify steps of different types of protein aggregate maturation human brain samples will be analyzed biochemically and neuropathologically. The biological effects (e.g. on nucleocytoplasmic transport) and toxicity of the aggregates will be tested in cell culture systems of human-derived induced pluripotent stem cells (iPSCS).

We are looking for highly motivated candidates to explore the role of C9ORF72 in neurodegeneration associated with amyotrophic lateral sclerosis (ALS). ALS is a motor neuron disease characterised by progressive injury and death motor neurons in the brain and spinal cord. Recent reports suggest that C9ORF72 hexanucleotide intronic repeat expansion cause ALS with high prevalence in both familial and sporadic cases. The C9ORF72 gene is located on chromosome 9p (9p21) and encodes twelve exons, with three transcription variants, and two possible protein isoforms, termed a and b. The normal expansion typically comprises a fewer than 30 of GGGGCC repeats. Pathogenic expansions consists of hundreds to thousands repeats. RNA foci are observed in fibroblasts and CNS of patients with C9ORF72 expansion, suggesting defects of RNA metabolism. Despite the significant progress in C9orf72 research, the exact function of the C9orf72 protein remains unclear. Thus, further research efforts aimed at better understanding the role of C9ORF72 protein are of the utmost importance to enable therapeutic development for ALS.

The major focus of the project is on extracellular vesicles and motor neuron degeneration with a particular interest on the role of RNA in the glia-motoneuronal intercellular communication. The PhD student will acquire expertise on extracellular vesicles analysis, RNA profiling in the field of neurodegeneration.

Applications are now being invited for a three-year Basic Science PhD Studentship funded by Alzheimer’s Society, starting in October 2017. The successful candidate will join an established training programme at the Sheffield Institute for Translational neuroscience (SITraN) in the group of Dr Kurt De Vos. Expansions of a noncoding GGGGCC hexanucleotide repeat in the C9ORF72 gene are the most common genetic defect found to date in frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). How the repeat expansion causes disease is not known, but appears to involve both loss-of-function (C9ORF72 haploinsufficiency), and gain-of-function (repeat-associated non-ATG (RAN) translation, RNA toxicity) mechanisms. To unravel the ways in which C9orf72 expansions cause disease it is crucial to understand the normal functions of the C9orf72 protein. In this project we will investigate how the cellular levels of C9orf72 are regulated and leverage this knowledge to devise novel therapeutic strategies. Candidates must have a first or upper second class honors degree or significant research experience.

We are looking for a highly motivated student to investigate the contribution and role of circular RNAs (circRNAs) in the development of neurodegenerative diseases. The student will join the Kadener lab in Jerusalem, a multidisciplinary team studying the role of circRNAs in physiology and disease in Drosophila. The position is part of circTrain (https://circtrain.eu/) an EU-funded International Training Network (ITN) that focuses on different aspects of circRNA biology.

Alzheimer’s disease (AD), Parkinson’s disease (PD) and Amyotrophic lateral sclerosis (ALS) areneurodegenerative disorders (NDs) with proteostasis defects. They represent an ideal set of diseases covering >70% of patients to increase our understanding of the molecular basis of NDs. The associated pathologies are difficult to truly model and compare using animals because (i) they are mainly caused by sporadic forms of the diseases, and (ii) models do not recapitulate the basic cellular changes observed in patients. Our aim is to achieve a global understanding of RNA translation and stress granules regulation across these neurodegenerative diseases using novel genetically engineered isogenic human stem cell lines. This will identify key regulatory nodes, across diseases, revealing new points for therapeutic interventions.The PhD candidate will work as part of an EU/MRC-funded trans-national consortium that has developed control fibroblasts genetically engineered into disease cell lines (project grant MR/R02426X/1), allowing studies within identical genetic backgrounds. Following training with our project partners at McGill (Canada) and QMUL (UK), the control and disease-model iPSCs will be used to differentiate neuronal cell populations including forebrain cortical-like neurons, midbrain dopamine-like and glial astrocyte-like cells. Subsequently, the candidate will be trained in confocal microscopy techniques to detect and quantity stress granules in cells, measure translational activity globally and specifically at the mRNA level using ribosomes profiling.

The aim of this project is to disentangle the converging molecular pathomechanisms in the frontotemporal dementia – amyotrophic lateral sclerosis spectrum. We will pursue this goal by investigating different mouse models using state-of-the-art proteomic and transcriptomic technologies. Using this approach, we intend to unravel the disease mechanisms already at presymptomatic stages.

At TU Dresden the Junior Research Group of Dr. Jared Sterneckert, “iPS Cells and Neurodegenerative Disease” at the Center for Regenerative Therapies Dresden (CRTD), an Institute of the Center for Molecular and Cellular Bioengineering (CMCB), is calling for applications for a PhD scholarship. The Scholarship starts as soon as possible and is initially limited until Aug 30th 2020 with an optional extension. Dr. Sterneckert’s group uses patient specific induced pluripotent stem (iPS) cells to generate models of neurodegenerative diseases, including Parkinson’s disease and amyotrophic lateral sclerosis. Using a combination of gene editing, proteomics, and small molecules, we aim at understanding the mechanism(s) of pathogenesis and identifying novel treatments. The aim of this project is to use iPS cell-derived neurons in combination with patient biosamples to study amyotrophic lateral sclerosis, particularly the role of exosomes.

Dr. Christine Vande Velde is looking to recruit a graduate student to her laboratory located at the CRCHUM facility, a research center affiliated with the Université de Montréal and located in Downtown Montreal.

The Neurobiology Division of the Medical Research Councils Laboratory of Molecular Biology (MRC LMB) invites applications for a Programme Leader-Track position. We seek a scientist with a focus on the elucidation of fundamental molecular mechanisms that determine the structure and function of the neuronal synapse, in health and disease. An emphasis on the development and application of molecular neurobiological approaches is essential, and the application of cutting-edge light and/or electron microscopic imaging is encouraged. The primary selection criteria are scientific excellence and potential for synergy with our existing research programmes, both within the Division (encompassing neuronal molecular cell biology, neural circuits and simple behaviours, and the molecular/ cell biological basis of neurodegeneration) and across the wider LMB. You should hold a PhD and have an excellent publication record, be internationally recognised for your work and have outstanding potential for independent research.

Denali Therapeutics is seeking to recruit a Group Leader to lead the company’s translational biomarker efforts. S/he will be responsible for leading translational biomarker strategies and developing and implementing biomarker assays to assess the target engagement and PK/PD/response relationships of drug candidates in both preclinical models and clinical trials.

The University of Texas Southwestern Medical Center, Center for Alzheimer’s and Neurodegenerative Diseases (CAND), is seeking applications for a faculty position as Head of Translational Science. Responsibilities include supporting the translation of novel targets and inventions into viable drug development and/or patient care solutions, engaging with Principal Investigators (PI’s), postdocs, and students to advance inventions from CAND laboratories, advancing high-throughput screening (HTS) hits into lead series, optimizing lead series to IND-ready clinical candidates, connecting entrepreneurs, bankers, and venture funds with CAND science, and utilizing Contract Research Organization (CRO) network to rapidly and cost-effectively advance CAND programs. Appointment rank will be commensurate with academic accomplishments and experience.Candidates must have a Ph.D. in chemistry, life sciences or a related discipline, practical experience in advancing drug programs into the clinic and validation of novel targets with in vivo proof of concept experiments.Desired skills include medicinal chemistry and DMPK expertise, hit and lead series evaluation, competitive analysis of programs, intellectual property path advisement, ability to connect CAND PI’s with resources such as CRO’s for chemistry and pharmacology, on-campus capabilities and UT System resources, grant writing, and design and interpretation of clinically relevant PI/PD experiments.

The Grenoble Institute of Neurosciences (GIN), an outstanding research center devoted to understanding brain functions and the development of innovative clinical therapies for neurological, neuromuscular and psychiatric disorders, is welcoming applications for positions as junior and senior group leaders in basic and/or clinical research.

The position is for a Lab Manager to help facilitate all daily lab operations. The individual will report to a Principal Investigator (PI) in neuropathology research that investigates the pathogenesis of Alzheimer’s disease, frontotemporal dementia, and related disorders. A successful candidate will have excellent communication skills, highly confident decision making ability, experience managing multiple projects and life sciences lab management, and embrace the highly dynamic environment.

The position is responsible for, and critically important to Neurosciences Clinical Research Unit (NCRU), and Memory and Aging Center (MAC) investigators for the overall operational management of clinical research activities for the biospecimens processing lab. The Lab Manager has direct responsibility for implementing a diverse portfolio of processing protocols which include multicenter clinical trials (both NIH and industry-sponsored), local investigator-initiated clinical trials, and clinical research activities, including a clinical database and biorepository LIMS system.

The position is for a part time Lab Technician / Staff Research Associate I (SRA I) to assist the Principal Investigator (PI) in neuropathology research that investigates the pathogenesis of Alzheimer’s disease, frontotemporal dementia, and related disorders at UCSF Mission bay campus ( see http://grinberglab.ucsf.edu). The candidate is expected to be open to learning new methods.

Denali Therapeutics is dedicated to developing breakthrough therapies for neurodegenerative diseases through our deep commitment to the genetics and biology of neurodegeneration and the principles of translational medicine. In anticipation of the Company’s growth plans, Denali Therapeutics is seeking to recruit a Medical Director. The Medical Director will be responsible for design, implementation, monitoring, analysis, and reporting of clinical trials and will provide strategic leadership for development programs.

The position of Associate Medical Director/Medical Director, Clinical Development sits within Pain, Neuromuscular and Rare Disease of Late Stage Clinical Development. The new Medical Director will support neuromuscular indications including Spinal Muscular Atrophy (SMA) and Amyotrophic Lateral Sclerosis (ALS). The successful candidate will demonstrate the flexibility and capability to function at a high level across multiple studies. Activities include direct responsibility for advancing high priority clinical programs through clinical study design and execution, development of biomarker strategies, as well as interpretation of data from key clinical studies. The individual who assumes this position will interact with multiple levels of management within Biogen, external stakeholders in the medical community as well with global regulatory authorities.

Verge Genomics is seeking a Neurobiology Research Associate II to join the Drug Discovery team. This candidate will gain pharmaceutical industry experience in a cutting-edge academic lab in the SF Bay Area and at Verge Genomics headquarters in SF. The candidate will be part of a multifunctional team with responsibility for target validation and evaluation of novel drug candidates for neurodegenerative diseases. The candidate will conduct in vivo studies in mice, including neonatal intracerebroventricular injections, and drug administration by oral routes. Experience with stereotaxic surgery, gene therapy (AAV9 or ASO), behavioral observations, gait analysis, rotarod and grip strength, and genotyping are a plus. The ideal candidate will have excellent problem-solving skills and familiarity with statistical analysis. This position reports to a PhD Scientist. The candidate will also culture motor neurons differentiated from induced pluripotent human stem cells and aid in the design and development of cellular assays to identify genes and compounds for treating neurodegenerative diseases including amyotrophic lateral sclerosis (ALS). The candidate will have extensive experience with sterile in vitro laboratory tasks, including harvesting, storing, growing, and expanding neuronal cultures, formulating and adding compounds and molecular probes, measuring cell numbers with light microscopy and properties based on immunohistochemical markers, and writing SOPs and detailed records of all work.

The Center for Alzheimer’s and Neurodegenerative Diseases at UT Southwestern Medical Center is accepting applications for a Board eligible/certified neurologist with an interest in cognitive and memory disorders. Research areas could include: 1) Running clinical trials; and 2) Studying clinical/pathological correlations of imaging and blood/CSF biomarkers. This faculty position will have a joint appointment in the Department of Neurology and Neurotherapeutics and the work will involve the interface of clinical and basic research.

The Peripheral Nervous System, Muscle and ALS Department, Pasteur 2 new Hospital, CHU de Nice (France) is actually seeking a Neurologist with immediate availability for a Clinical and Research position. This department is certified as Neuromuscular Diseases Reference Center and ALS Reference Center. These Centers are affiliated to French rare diseases Healthcare Network (FILNEMUS) and French rare diseases Healthcare Network: Amyotrophic lateral sclerosis and rare motor neuron diseases (FILSLAN). The Department has also been labeled as being part of the European Reference Networks-NeuroMuscular Diseases (ERN-NMD) as Center of Excellence.

As a neurologist on the Neurology and Rehabilitation Service at the Oklahoma City Veterans Affairs Health Care System,who subspecializes in rehabilitation. The duties of this position include: supervise residents and students and attend on the neurology inpatient service 2-3 months annually; attend on the rehabilitation inpatient service2-3 months annually; direct the power-mobility clinic; direct the spinal cord injury, spinal cord diseases, multiple sclerosis, and amyotrophic lateral sclerosis clinic; direct the stroke-care program. The applicant must be able toprovidecare and rehabilitation tothe following populations ofveterans: acute neurology patients in all outpatient and outpatient settings including intensive care units and emergency room; spinal cord injury, spinal cord disease, ALS and MS in the Hub and Spoke system of care; disabled patients due to neurological or orthopedic impairments for rehabilitation care on outpatient and inpatient settings. The applicant must be able to provide acute stroke and post-stroke care and supervise neurology stroke fellows who rotate at the VA. The applicant must participate in ongoing CARF accreditations activities for a Comprehensive Integrated Inpatient Rehabilitation Program, and assist in meeting standards forspecial accreditation in Stroke Rehabilitation. The applicant must be able to supervise neurology stroke fellows, neurology residents, other trainees and students who rotate on the Neurology Inpatient and Outpatient Service, and therefore must meet criteria for faculty appointment in Neurology at the University of Oklahoma Health Science Center.

The Department of Pathology at Northwestern University Feinberg School of Medicine seeks a full-time Assistant Professor, Associate Professor or Professor on the tenure track. Qualified candidates will be physician-scientists MD or MD, PhD, and be Board-certified in Neuropathology. They are expected to develop a federally funded, independent research program in the area of neurodegeneration and engage in collaborations with other researchers who study neurodegenerative diseases throughout Northwestern University.

SOUTHERN RESEARCH is seeking an outstanding scientist to join the faculty of the Chemistry Department in the Drug Discovery Division. We are particularly interested in attracting a scientist with an established research program with excellent translational potential toward the identification of novel therapeutic agents. Chemists with a strong desire to collaborate with biochemists, microbiologists, and our high-throughput screening center, especially in the areas of oncology, anti-infectives, or CNS and neurodegenerative diseases, are particularly encouraged to apply.

An exciting opportunity has arisen for a PhD project in the field of neuroimaging in motor neuron disease (MND). MND is a devastating, fatal, incurable neurodegenerative condition that typically results in death within 2-3 years. Therapeutic efforts have been limited by an incomplete understanding of disease pathophysiology, and because an available biomarker is lacking with which to track therapeutic effects over short timescales; for this reason, many potential agents never make it to clinical trial. There is increasing evidence for abnormal energy metabolism in MND, both a hypermetabolic early phase characterised clinically by weight loss and, later, mitochondrial failure, which may contribute to motor neuronal cell death.

The Center for Translational Medicine (CTM) at the Lewis Katz School of Medicine at Temple University is seeking qualified candidates and candidate nominations for a Tenure Track Faculty Physician-Scientist dedicated to neurodegeneration research. This position will also have clinical responsibilities and a joint appointment in the Department of Neurology.

West Virginia University School of Medicine, Department of Pathology, Anatomy and Laboratory Medicine seeks an academically oriented, Board Certified/eligible Neuropathologist qualified for appointment at either the Assistant Professor, Associate Professor, or Professor rank with skills in surgical and autopsy neuropathology. Experience and ability to participate in other pathology specialty functions is desirable but not required. Pathologists with an academic focus in the neurosciences (eg, neurodegenerative disorders, tumor, stroke, etc) are encouraged to apply. Other service responsibilities and the effort levels designated in support of our academic and clinical service missions will be based on a candidate s training, skills and passions, as well as departmental and institutional needs. In addition to providing patient care, the successful candidate will be involved in the teaching of medical students and residents. For appointment at the Associate Professor or Professor rank, it is expected that candidates sustain an outstanding, extramurally supported research program.

The Center for Translational Medicine (CTM) at the Lewis Katz School of Medicine at Temple University is seeking qualified candidates and candidate nominations for a Tenure Track Faculty Physician-Scientist dedicated to neurodegeneration research. This position will also have clinical responsibilities and a joint appointment in the Department of Neurology.

General Summary: The Single Motor Unit Laboratory (SMPP) strives to understand how the nervous system controls individual motor units within a muscle so as to enable the generation of muscle force. Seeks to investigate the role of intrinsic properties of motoneurons that innervate relevant muscle fiber populations in providing such control under normal conditions and following such illnesses as stroke, spinal cord injury (SCI) and amyotrophic lateral sclerosis (ALS).

Sanofi’s Neuroscience Research Therapeutic Area based in Framingham, MA is looking for a highly qualified and motivated Postdoctoral Scientist to investigate the underlying disease biology of amyotrophic lateral sclerosis (ALS). The successful candidate will implement manifold in vitro and in vivo experimental approaches to help identify and validate innovative therapeutic targets for the treatment of ALS. These techniques include molecular biology, biochemistry, cell culture, immunoblotting, immunohistochemistry, microscopy, laser capture microdissection and the use of transgenic mouse models.

The PostDoc Fellow will participate in the discovery and evaluation of candidate targets affecting motor unit function and subsequent sensory motor performance following stroke, SCI, and/or ALS. The PostDoc Fellow may also be expected to study the effects of various clinical interventions in order to aid the design of rehabilitation strategies targeting specific motor unit properties.

The international “Regulatory T cell responses at the crossroads of immune homeostasis and inflammation in the context of barrier diseases” (TregBar) project is an international research project funded by the Luxembourg National Research Fund`s (FNR) bilateral AFR funding instrument. The program will initiate long-term collaborations between the biomedical initiatives of the Luxembourg Institute of Health (Esch-sur-Alzette, Luxembourg) and the Luxembourg Centre for Systems Biomedicine of the University of Luxembourg with the RIKEN Center for Integrative Medical Sciences (IMS) in Yokohama, Japan.

The lab for microRNA Models of Neurodegenerative Disease at the Institute of Molecular and Cell Biology is seeking to recruit a highly motivated Research Fellow to investigate pathogenic pathways underlying neurodegeneration linked to loss of microRNA function.

The successful candidate will participate in federal and private-funded projects aiming to understand the role and molecular mechanism of autophagy (an essential lysosomal degradation pathway) in the regulation of metabolism and animal behavior, using knockout, knockin and transgenic mice, cell biology, biochemistry, imaging and state-of-the-art behavioral techniques.

We are seeking a highly motivated postdoctoral associate interested in proteinopathy research in the context of neurodegenerative diseases. The successful candidate will be responsible for developing in vitro models to understand underlying mechanisms of pathogenic protein inclusion formation in the brain. The ideal candidate should have excellent communication and writing skills and the ability to work well in a multidisciplinary team. The candidate will periodically present his/her results and will prepare manuscripts for publication of findings in a peer-reviewed journal.

Sanofi’s Neuroscience Research Therapeutic Area based in Framingham, MA is looking for a highly qualified and motivated Postdoctoral Scientist to investigate the underlying disease biology of amyotrophic lateral sclerosis (ALS). The successful candidate will establish in vitro human glial and neuronal models to identify and validate innovative therapeutic targets for the treatment of ALS. The candidate will also evaluate the impact of engaging these novel targets in ALS transgenic mouse models.

Dr. Anne Bang leads efforts at the Conrad Prebys Center for Chemical Genomics to develop patient cell specific and human induced pluripotent stem cell (hiPSC)-based disease models for drug screening and drug target identification. Her research program is primarily focused on neurological and neuromuscular disease, with the aim of designing human cell-based models and assays that reflect higher order cellular functions and recapitulate disease phenotypes, yet have the throughput and reproducibility required for drug discovery.

We are looking to hire a postdoctoral fellow holding a PhD in Bioinformatics or Genetics/Epigenetics with strong expertise in next-generation sequencing (NGS) data analysis to lead the bioinformatic component of our research program. That person will be proficient in C++, Java, Python, R and unix environments, including supercomputing applications. Optimally, the recruited person will also have expertise in conducting statistical analyses and algorithm development. The individual needs to be independent and motivated to perform genomic, epigenomic and transcriptomic analyses — the primary mentor will be Dr. Veronique Belzil and a bioinformatics professor will be available for guidance.

There is a post doc position available to work within the Group of Dr Anne Bertolotti at the Laboratory of Molecular Biology (LMB), within a programme aimed at capitalizing on our pioneering discoveries on phosphatases. The work aims at elucidating phosphatases structure and function reconstituting phosphatase inhibition using purified components. This research programme will bring fundamental discoveries with a translational potential relevant to a group of devastating and so far incurable diseases.

The Department of Neuroscience has an opening for a qualified and highly motivated Postdoctoral Research Associate. The successful candidate will join Dr. Martha Bhattacharya’s laboratory which is focused on the molecular and cellular study of nerve damage responses in both mice and Drosophila (fruit flies). The long-term goal of our research is to identify ways to delay or prevent the degeneration of axons in neurodegenerative diseases, thus preserving nerve function. Candidates who are eligible to compete for postdoctoral funding, such as the NIH Ruth L Kirschstein Institutional National Service Awards (NRSA), are strongly preferred.

The Boulis laboratory in the department of Neurosurgery at Emory University in Atlanta, GA, is seeking a capable and self-motivated individual to oversee projects involving the transplantation of iPS cells for the treatment of motor neuron diseases and nerve damage.

A position is available in the Buchan lab to study cytoplasmic mRNA biology. We are particularly interested in the assembly, disassembly and function of stress granules and P-bodies, which are cytoplasmic mRNA-protein (mRNP) assemblies that are implicated in regulation of mRNA translation, storage and decay. Recent evidence also suggests important roles for these mRNP bodies in viral defense, cancer and neurodegenerative diseases. A related focus is on the role of vesicular trafficking pathways in mediating clearance of P-bodies, stress granules and aggregates of proteins implicated in neurodegenerative disease such as Amyotrophic Lateral Sclerosis (ALS).

The Department of Cell Biology and Neuroscience at Rutgers University is currently accepting applications for a postdoctoral position to study (1) the cellular mechanisms regulating autophagy-lysosomal function; (2) how altered axonal transport impacts the autophagy-lysosomal system, leading to axonal degeneration; (3) how deficits in the endolysosomal pathway contribute to the dysregulation of neuronal signaling. Given that defective axonal transport has been implicated in the pathogenesis of major neurodegenerative diseases, our studies will yield fundamental information to advance our understanding of human neurodegenerative diseases. Candidates for this position should hold a PhD with a strong research background in neurobiology or cell biology, at least in one of these areas: membrane trafficking, organelle transport, mitochondrial quality control, neuronal signaling, and neurodegenerative mouse models. Interested individuals should send CV, a personal statement describing research interests, and names and details of 3 references to [email protected]. Att: Qian Cai, M.D., Ph.D. Department of Cell Biology and Neuroscience, Rutgers, The State University of New Jersey, Nelson Biological Laboratories, Busch Campus, 604 Allison Road, Piscataway, NJ 08854. Lab Webpage: https://cbn.rutgers.edu/cb-profile/userprofile/qc29 Application review will begin immediately and will continue until a suitable candidate is selected.

The University of Florida, Department of Pediatrics, Vijay Chandran Research Laboratory seeks a highly motivated Postdoctoral Research Associate to join a team studying the molecular mechanisms of neurodegeneration (Elife, PMID: 29257745) and axon regeneration (Neuron, PMID: 26898779; Cell Report, PMID: 29386116) after CNS injury and neurological diseases, using various in vitro and in vivo model systems. The Vijay Chandran Laboratory accomplishes this by integrating various omics techniques (genomics, proteomics, and metabolomics) with basic neurobiology and systems analyses (Cell, PMID: 24267887; Genome Biology, PMID: 18402659; PNAS, PMID: 29946024) to develop a more systematic understanding of nerve injury and neurodegenerative conditions.

A Postdoctoral Research Fellowship is available in the Laboratory of Synaptic plasticity and Repair of Imperial College London, starting immediately. The aim of this project is to gain new and fundamental insights into the cellular and molecular mechanisms that regulate the regeneration of adult neocortical circuits. We have previously demonstrated that certain populations of cortical neurons exhibit enhanced spontaneous regenerative capacity compared to others, and we are now interested in understanding the mechanisms responsible for this differential response to injury. Our goal is to develop effective strategies to enhance functional axon and synaptic regeneration (Holtmaat et al Nature protocols 2009; Canty et al Nature Communications 2013; Grillo et al Nature Neuroscience 2015).

A position for a talented and highly motivated Postdoctoral Researcher is available within the scientific team “Mitochondria and Inflammation in Neurodegeneration” led by Michela Deleidi in Tübingen. The research focus of our group is on the molecular mechanisms of neurodegeneration, with a special emphasis on the role of inflammation in neurodegenerative diseases. Neuroinflammatory genes have been associated with several neurodegenerative diseases, including Parkinson’s disease. Our aim is to understand, at the molecular level, how immune responses within or outside the brain contribute to neurodegeneration. Our final goal is to translate fundamental discoveries to better preventive and therapeutic approaches for neurodegenerative diseases. Please see our website for more information about our research: https://www.dzne.de/en/research/research-areas/fundamental-research/research-groups/deleidi/research-areasfocus/.

A postdoctoral position in ALS research is available in the laboratory of Dr. Heather Durham in the Rare Neurological Diseases Group at the Montreal Neurological Institute, McGill University, Montreal QC Canada. The project involves investigating the role of chromatin remodeling as a convergent mechanism in ALS and in neuronal stress responses (see https://www.ncbi.nlm.nih.gov/pubmed/28973294). The work would include investigation of epigenetic mechanisms in primary culture models, mouse models and post-mortem tissue as well as participation in a drug study in mouse and tissue culture models of ALS. This multidisciplinary project is funded by MDA and by an ALS Canada-Brain Canada Hudson Translational Team Grant involving collaborators with complementary expertise at other Canadian universities.

We have a postdoctoral position available in the laboratory of HHMI Investigator, Tobias Walther, Ph.D., and Robert V. Farese, Jr, M.D., who jointly run a highly collaborative group at the Harvard School of Public Health. The lab is located in the Boston Longwood medical campus and is affiliated with the Department of Genetics and Complex Disease (HSPH), the Department of Cell Biology (Harvard Medical School), the Broad Institute of MIT and Harvard, and the Howard Hughes Medical Institute.

The Fitzpatrick lab, a member of the Mortimer B. Zuckerman Mind Brain Behavior Institute at Columbia University in the City of New York (https://zuckermaninstitute.columbia.edu/), has openings for four postdoctoral scientists opportunities.

Are you an expert in neurodegeneration, with a passion for research that will have an impact on curing disease? We seek a talented post-doc to participate in an unprecedented study of the neurodegenerative disease ALS. Working with researchers at clinical and academic institutions across the United States, we are gathering data on approximately 1,000 ALS patients and controls. Induced pluripotent stem cell (iPSC) lines are being derived from each individual and these are being used to generate motor neurons for a wide range of omic studies. Our collaboration seeks to identify different subtypes of the disease, identify correlations between molecular pathways and clinical symptoms and propose therapeutic strategies.

Motivated PhD graduates seeking research training in the cell biology of neurodegenerative disease are invited to apply to postdoctoral research position(s) in the Department of Pathology at Yale University. Successful candidates will utilize live cell and super-resolution imaging techniques, mass spectroscopy/CyTOF and biochemistry in primary neurons and mouse models, iPSC-derived neurons, and/or patient tissue samples to define the molecular mechanisms driving assembly, transport, and cellular functions of neuronal ribonucleoprotein (RNP) complexes under physiologic conditions and in neurodegenerative disease.

Postdoctoral positions are available in Dr. Junjie Guo’s lab in the Department of Neuroscience at Yale School of Medicine. The Guo lab studies questions at the intersection between RNA biology and neuroscience. Currently, we are interested in the roles of mRNA and noncoding RNA structures in neurodevelopment and neurodegenerative diseases, taking a combination of computational, biochemical, genetic, and genomic approaches. Our lab is situated within the dynamic and collaborative RNA biology and neuroscience communities at Yale that includes the Yale Center for RNA Science and Medicine, the Program in Cellular Neuroscience, Neurodegeneration and Repair (CNNR), and the Kavli Institute for Neuroscience at Yale.

This post doctoral research opportunity focuses combining microfabrication and cell culture to construct in vitro models of the human body or “Body-on-a-Chip” for use in drug development. Multiple organs and their physiological interactions are represented on a single device; these interactions are based on physiologically based pharmacokinetic models. Of particular interest will be to combine metabolically active tissue, such as from the liver, with electrically active tissues such as cardiac myocytes or neuronal cells and then conduct pharmacological studies in this system.

A postdoctoral position is available at Cornell University to study lysosomal dysfunction and neurodegeneration in ALS and FTLD. Highly motivated individuals with a strong background in cell biology or mouse genetics and an interest in neurodegenerative diseases are encouraged to apply. Please visit http://hu.wicmb.cornell.edu/ for more details and send your CV and 3 letters of references.

A postdoctoral position is presently available in the laboratory. The focus of the laboratory is Molecular Neuropharmacology/Neurodegeneration. Oxidative stress is believed to be a principal factor in the development of many chronic neurodegenerative diseases such as Alzheimer’s, Parkinson’s, Huntington’s and Amyotrophic Lateral Sclerosis. My laboratories goal is to discover ways to increase the defense mechanisms in brain by activating multiple antioxidant defense genes simultaneously through activation of the Nrf2-ARE pathway. Present work in the laboratory is focused on: 1) signaling mechanisms responsible for Nrf2-mediated neuroprotection using proteomics and RNAseq; 2) role of astrocytes in Nrf2-mediated neuroprotection; 3) the role of Nrf2 in microglial activation; and 4) viral-mediated delivery of Nrf2 and/or transplantation of Nrf2 into animal models of Alzheimer’s and Parkinson’s Disease.

Postdoctoral positions are available in the ALS Neuroimaging Research Unit at the University of Alberta. The mission of the lab is to further our understanding of the biology of amyotrophic lateral sclerosis (ALS) using advanced MRI methods. The lab is directed by Dr. Sanjay Kalra, a neurologist and researcher, and the director of the Canadian ALS Neuroimaging Consortium (CALSNIC).

Applications are invited for a Postdoctoral Research Associate (PDRA) to work on the development and applications of a microfluidic platform for analysing of Fused in Sarcoma (FUS) protein assembly, with a focus on liquid-liquid phase transitions using recombinant protein, cellular and cultured neuron systems, a project funded by the Wellcome Trust. The PDRA will work in the group of Professor Knowles in the Department of Chemistry.

We are seeking a motivated post-doctoral fellow who works well with others as part of a research team. The ability to design, conduct, and report on research experiments is required. Communication skills, organizational skills, and a willingness to learn new approaches are of paramount importance. The fellow will pursue the underlying causes of aging associated protein aggregation in neurodegenerative disease using genome editing approaches in C. elegans and/or mammalian model systems.

Under the supervision of the Principal Investigator John Landers, the Postdoctoral Associate would be investigating the pathogenesis of ALS caused by mutant genes through a combination of live cell imaging techniques and next-generation sequencing approaches.

A postdoctoral research position is available in the Liachko lab located at the Veterans Affairs hospital in Seattle, and affiliated with the University of Washington (http://depts.washington.edu/geront/directory/bios/liachko.html). We use model systems including mouse primary neurons, cultured human cells and C. elegans, to study the neurodegeneration seen in amyotrophic lateral sclerosis, Alzheimer’s disease, and other aging related disorders.

Postdoctoral positions are available at Johns Hopkins University School of Medicine to study cellular mechanisms underlying degenerative diseases of the neuromuscular system such as Inclusion Body Myositis (IBM) and Amyotrophic Lateral Sclerosis (ALS) in the laboratory of Thomas E. Lloyd, MD PhD. We are actively recruiting for a postdoctoral fellow to work on a mouse model of myosits in which human muscle biopsies are xenografted into immunodeficient mice. This exciting precision medicine initiatve will explore the interaction between the immune system and regenerating muscle in autoimmune and degenerative muscle and motor neuron diseases. Expertise in immunology, muscle, or mouse models of neuromuscular disease is preferred. The Lloyd laboratory uses a combination of genetic, molecular, cellular, physiologic, and imaging approaches in Drosophila, mouse, and iPS models in addition to human brain and muscle tissue to study the cell biology of degenerative diseases affecting the neuromuscular system.

The ALS Center for Cell Therapy and Regeneration Research at Johns Hopkins is seeking a postdoctoral fellow to participate in research utilizing human induced pluripotent stem cell models of neurodegenerative disease, with an emphasis on motor neuron diseases (ALS). The fellowship will use stem cell methodologies to both investigate disease pathogenesis as well as evaluate potential therapeutics. There is also a programmatic interest in the investigation of astrocyte-mediated contributions to the progression of disease in ALS with an emphasis on human iPSC-derived astrocyte biology and electrophysiology.

The Meyer laboratory is focusing on research in life-threatening Neurodegenerative and Neurological Disorders such as Amyotrophic Lateral Sclerosis and Spinal Muscular Atrophy, Rett Syndrome and Batten Disease. We investigate disease mechanisms using state-of-the-art in vitro models and reprogramming techniques. Our efforts are motivated by finding a treatment that can be translated to the clinic. Using gene therapy, we have successfully translated several of our approaches to the clinic and continue to work hand-in-hand with clinicians at the hospital to move additional programs forward.

The Meyer laboratory is focusing on research in life-threatening Neurodegenerative and Neurological Disorders such as Amyotrophic Lateral Sclerosis and Spinal Muscular Atrophy, Rett Syndrome and Batten Disease. We investigate disease mechanisms using state-of-the-art in vitro models and reprogramming techniques. Our efforts are motivated by finding a treatment that can be translated to the clinic. Using gene therapy, we have successfully translated several of our approaches to the clinic and continue to work hand-in-hand with clinicians at the hospital to move additional programs forward.

The collaborative and interactive Arizona postdoctoral fellowship program in Neurobiology of Aging and Neurodegenerative Disease is seeking highly qualified applicants for positions supported by a National Institutes of Health training grant. Institutions included in the research consortium include the University of Arizona, Arizona State University, Barrow Neurological Institute, The Translational Genomics Research Institute, Banner Alzheimer’s Institute, Banner Sun Health Research Institute, and Mayo Clinic. All institutions are participants in the state wide Arizona Alzheimer’s Consortium. Training programs afford the opportunity to study neurodegenerative disorders such as Alzheimer’s disease, Parkinson’s disease, and Amyotrophic Lateral Sclerosis, Traumatic Brain Injury, other related disorders, as well as non-pathological brain aging. Areas of interest include behavioral, systems and clinical neurosciences, molecular neurobiology and epigenetics, brain imaging, genomics, computational and statistical analysis of complex data sets, experimental therapeutics, and clinical neuropathological research. Research resources include human longitudinal cohorts and data sets, a brain and body research donation program, PET and MRI research programs, wild type and transgenic rodent, non-human primate and human behavioral testing facilities, and cutting-edge cellular and molecular biological research methods with emphasis within each of the noted disciplines. Trainees will benefit from a Professional Development Committee to foster career development from an omnibus perspective, and the training experience will be enriched via opportunities to work, learn, and produce across institutions, driven by a collaborative experimental training plan. This is a U.S. Government funded training grant and is only available to U.S. citizens or Permanent Residents. All institutions involved in this training program value our inclusive climate because we know that diversity in experiences and perspectives is vital to advancing innovation, critical thinking, solving complex problems, and creating an inclusive academic community. Because, we seek a workforce with a wide range of perspectives and experiences, we encourage diverse candidates to apply, including people of color, women, veterans, and individuals with disabilities.

As postdoc you will be working on data from Project MinE (www.projectmine.com). This is unique genomic dataset in the field of Amyotrophic Lateral Sclerosis (ALS), a rapidly progressive, invariably fatal neurological disease that attacks the nerve cells responsible for controlling voluntary muscles, which include epigenetic, whole genome sequencing and clinical data of several thousand of ALS patients and matched controls. We have recently published the first results of this dataset (Van Rheenen et al. Nat Genet. 2016 (PMID: 27455348), and Kenna et al. Nat. Genet. 2016 (PMID: 27455347)). Your focus will be on exploring adding external controls and cases to this dataset while preserving type I error in case-control comparisons, annotating the non-coding genome by integrating our data with other publicly available omics datalayers, including RNAseq, Hi-C and Chip-seq and relating this to case-control status. Another type of genomic variation potentially related to ALS we are interested in, is structural variation. This means you need to have experience in working with raw sequencing data on a large number of samples and be able to apply complex genetic statistics in this context. There is a suitable ICT setup available for you to achieve this. We expect you to be able to use various bioinformatic tools on next-generation sequencing data and combine these to identify possible novel ALS risk genes, and pathological pathways. Also, we would like you to integrate these genetic data with drug databases in order to prioritize potential new drug targets for ALS and repurposing of existing drugs for ALS. This part of the work will be done in collaboration with a biotech company. You will also be expected to participate in writing scientific papers and grant applications, provide methodological advice to other members of the team (bioinformaticians, PhD students, postdocs, technicians), and participate in educating bachelor and master students.

This position is funded by ForeFront, an NHMRC Program grant, that brings together a multidisciplinary research team to address the diagnosis, management and treatment of frontotemporal dementia and related disorders. A junior postdoctoral researcher is required to contribute to projects exploring the pathogenesis of neurodegeneration with a particular focus on immune-mediated mechanisms. This is a valuable opportunity to expand your research skills.

The Patsopoulos Laboratory at the Ann Romney Center of Neurological Diseases (ARCND), Brigham & Women’s Hospital and Harvard Medical School is seeking a highly-motivated post-doctoral fellow to be part of a leading team that aims to unravel the mechanisms of neurodegenerative and autoimmune diseases.

A postdoctoral position is available to study the maintenance, degeneration and regeneration of spinal motor neurons. Of particular interest for this position is the investigation of the intrinsic regenerative capacity of motor neurons, and how this is impaired during the pathogenesis of ALS. The laboratory employs state-of-the-art cellular, molecular, biochemical, mouse transgenic and imaging approaches for the interrogation of circuit development and physiology. The laboratory environment is energetic, collegial, highly collaborative, and strives for excellence. For a detailed description of our research goals visit the laboratory website.

The Department of Speech, Language, and Hearing Sciences at the University of Florida has a funded post-doctoral associate position available to work in the Swallowing Systems Core under the direct mentorship of Dr. Emily Plowman. This line is funded by an R01 grant from the National Institute of Neurological Disorders and Stroke (N.I.N.D.S) in the area of bulbar dysfunction in individuals with Amyotrophic Lateral Sclerosis. The successful post-doctoral associate would have the opportunity to work in the Swallowing Systems Core (SSC) that combines the expertise of both Dr. Plowman and Dr. Ianessa Humbert. The Swallowing Systems Core (SSC) is housed within the Dental Tower of Shands Hospital in the University of Florida Health Science Center and is equipped with its own research dedicated C-arm to perform high-resolution videofluoroscopy, fiberoptic endoscopic evaluation of swallowing workstation and high resolution manometry set up. The SSC currently comprises two Co-directors (Plowman and Humbert), two full time clinical coordinators, a biomedical engineer, four doctoral students, seven masters’ thesis students and five undergraduate honors students. The successful applicant would be expected to work cohesively with the entire SSC team.

The Stefan Pulst / Daniel Scoles Neurology Laboratory group at the University of Utah, Department of Neurology, invites applications for a postdoctoral fellowship for the study of cerebellar ataxia and other neurodegenerative diseases using calcium imaging and electrophysiological recordings. The Neurology Laboratory is well-funded by NIH, and other funding sources. We seek a highly motivated PhD in a related medical science who is interested in carrying out research on how RNA granules control localized calcium abundance and neuronal function in cultured cells and acute brain slices. The research objectives include understanding mechanisms of neurodegenerative disease as well as testing novel therapeutics in disease models.

Applications are being solicited for two NIH post-doctoral fellowships in respiratory neurobiology at the University of Wisconsin-Madison. The first position will investigate cellular mechanisms and physiological significance of neuroplasticity in the control of breathing, with an emphasis on sleep apnea. The second position will investigate functional outcomes of ex vivocell therapy (stem cell-based trophic factor delivery) to preserve respiratory motor neuron and diaphragm function in rodent models of Amyotrophic Lateral Sclerosis (ALS).

The Department of Neurology at the University of California, Irvine, invites applications for a post-doctoral fellow position in the laboratory of Dr. S. Ahmad Sajjadi MD, PhD beginning early 2017. The appointment is for 1 year with the possibility of extension upon satisfactory performance. We are seeking a highly motivated investigator with previous experience in neuropsychological assessments. Priority will be given to candidates with a recent PhD in neuroscience, psychology, or related fields and strong organizational and communication skills. The main purpose of this appointment is to establish a cohort of atypical dementia syndromes (mainly frontotemporal dementia) at the University of California, Irvine who will undergo regular clinical and neuropsychological assessments. Assessment of language and spontaneous speech will be a focus of the research and therefore, background in disorder of language will be desirable as is previous experience in neuro-imaging acquisition/analysis since the project will include structural MRI and PET scans. The position requires an individual who is an effective team player, highly organized, and innovative.

Dr, Dhruv Sareen’s independent research laboratory at the Cedars-Sinai Medical Center, Regenerative Medicine Institute focuses on using human iPSC technology to understand the molecular mechanisms underlying neurodevelopmental/degenerative diseases and how obesity is linked to the brain. His laboratory is particularly interested ‘disease-in-a-dish’ modeling for neuromuscular, neurodegenrative and motor neuron diseases including, amyotrophic lateral sclerosis (ALS). They are particularly interested in C9orF72 and other genetic forms of ALS and what are the common elements with sporadic forms of ALS. Using the iPSC platform his lab has developed novel methods for drug screening on patient motoneurons and dissecting mechanisms for motoneuron degeneration. In the context of stem cell modeling of neurodevelopmental (SMA) and neurodegenerative diseases (ALS) Dr. Sareen’s group is particularly interested in the mechanistic insights how specific neural cell types degenerate during the disease processes. They are using OMICS (proteome, transciptome, metabolome) and imaging methodologies to gain mechanistic insights into the mitochondrial and endorplasmic reticulum stress involvement. In addition, by understanding how the cells of the nervous system develop and differentiate we will be able to develop better and safer cells for transplantation and regenerative therapies. Dr. Sareen’s group has extensive experience in pluripotent and neural stem cell research. He has developed and directed a well-renowned human iPS cell core. He has published high-profile manuscripts on human iPSC-based disease modeling in SMA and ALS.

Dr. Dhruv Sareen’s independent research laboratory at the Cedars-Sinai Medical Center, Regenerative Medicine Institute focuses on using human iPSC technology to understand the molecular mechanisms underlying neurodevelopmental/degenerative diseases and how obesity is linked to the brain. His laboratory is particularly interested ‘disease-in-a-dish’ modeling for neuromuscular, neurodegenrative and motor neuron diseases including, amyotrophic lateral sclerosis (ALS). They are particularly interested in C9orF72 and other genetic forms of ALS and what are the common elements with sporadic forms of ALS. Using the iPSC platform his lab has developed novel methods for drug screening on patient motoneurons and dissecting mechanisms for motoneuron degeneration. In the context of stem cell modeling of neurodevelopmental (SMA) and neurodegenerative diseases (ALS) Dr. Sareen’s group is particularly interested in the mechanistic insights how specific neural cell types degenerate during the disease processes. They are using OMICS (proteome, transciptome, metabolome) and imaging methodologies to gain mechanistic insights into the mitochondrial and endorplasmic reticulum stress involvement. In addition, by understanding how the cells of the nervous system develop and differentiate we will be able to develop better and safer cells for transplantation and regenerative therapies. Dr. Sareen’s group has extensive experience in pluripotent and neural stem cell research. He has developed and directed a well-renowned human iPS cell core. He has published high-profile manuscripts on human iPSC-based disease modeling in SMA and ALS.

The Laboratory of Molecular Biology at The Rockefeller University is seeking a highly motivated and outstanding candidate for a postdoctoral position to study the selective vulnerability and degeneration of upper motor neurons in amyotrophic lateral sclerosis (ALS). ALS presents a paradox in that most known disease-causing mutations are ubiquitously expressed, yet only discrete populations of cells degenerate. We therefore use a multidisciplinary approach, centered on advanced molecular profiling methods to elucidate cell type-specific phenotypes during disease progression in preclinical mouse models and postmortem human tissue. By contrasting vulnerable and resilient neuronal populations as well as non-neuronal cells, we hope to identify novel disease mechanisms and putative entry points for therapeutic intervention These studies are also integrated with modern anatomical and circuit-tracing methods and behavior to map the identity, connectivity, and function of neuronal cell types in cortical and motor circuits.

The Single Motor Unit Laboratory (SMPP) strives to understand how the nervous system controls individual motor units within a muscle so as to enable the generation of muscle force. Seeks to investigate the role of intrinsic properties of motoneurons that innervate relevant muscle fiber populations in providing such control under normal conditions and following such illnesses as stroke, spinal cord injury (SCI) and amyotrophic lateral sclerosis (ALS).

Postdoctoral opportunities are available in Dr. Shuying Sun’s laboratory at Johns Hopkins University School of Medicine. The lab will explore the fascinating frontiers of RNA metabolism dysfunction and RNA-targeting therapy in neurodegenerative diseases by combining molecular and cellular approaches, genome editing, proteomic, genomic and screening platforms.

A postdoctoral position to study the molecular and cellular mechanisms of neurodegenerative disease, including amyotrophic lateral sclerosis and frontotemporal dementia, is available at the St. Jude Children’s Research Hospital in Memphis, TN, USA. We identified that many of neurodegenerative diseases are caused by defects in the assembly, disassembly, or clearance of cellular packages of RNA and proteins known as RNA granules. Our research focus is to investigate the role of RNA granules in regulating gene activity, explore how granules are assembled and disassembled, and investigate how these types of defects in RNA metabolism can cause neurodegenerative diseases.

The Laboratory of Neurobiology is part of the research group Experimental Neurology (Neuroscience Department) at KU Leuven. The group has a close collaboration with the Neurology Department of the University Hospitals Leuven with about 50 researchers in different domains.

Dr. Christine Vande Velde is looking to recruit a PostDoc to her laboratory located at the CRCHUM facility, a research center affiliated with the Université de Montréal and located in Downtown Montreal.

A postdoctoral research position is available immediately in the laboratory of Dr. Catherine Verfaillie, Stem Cell Institute, KU Leuven (https://www.kuleuven.be/scil/aboutusN/catherineverfaillie). The aim is to develop high-throughput functional screens of iPSC derived models. The Verfaillie lab created homogeneous populations of highly functional hepatocytes (that are gluconeogenic, with hepatocyte-like mitochondrial function, and CYP450 metabolisation, all similar to primary hepatocytes) as well as different neural progeny (cortical, motor, dopaminergic and sensory neurons; oligodendrocytes, astrocytes, microglia) from normal as well as patient derived and isogenic iPSCs, cultures which were down-scaled to 384 well format plates. In addition, using CRISPR/Cas technology, models that allow lineage tracing and toxicity/phenotypic readouts have been (can be created). Finally, complex 2D and 3D organoid culture models have (are) been developed to better model liver disease and / or neurodegeneration.

The lab of Dr. Verfaillie at the Stem Cell Institute Leuven is looking for a postdoctoral fellow with expertise in: The lab of Dr. Verfaillie at the Stem Cell Institute at KU Leuven is recruiting an outstanding postdoctoral fellow highly versed in pluripotent stem cell biology techniques, including multicellular organoid cultures either in 2.5D and in 3D in suspension or in hydrogel based static or bioreactor cultures. The goal is to create lifelike small brain tissues, including the blood brain barrier or the cortex, that can be used as disease models in a dish, to study, Alzheimer’s, Parkinson, frontotemporal dementia or ALS available from teams at KU Leuven and the Flemish Institute of Technology (VIB), using patient iPSC and their isogenic counterparts. The technology should enable gaining superior insights in mature brain features such as defined connectivity and neuron-glia interactions, neurodegeneration phenotypes, and identification of druggable phenotypes.

Adam Walker is seeking a postdoctoral fellow to join his laboratory at the University of Queensland in Brisbane, Australia. The lab focuses on molecular, cellular and mouse model studies of the causes and potential treatments for motor neuron disease (MND) and frontotemporal dementia. We are an enthusiastic, cooperative, dedicated and ambitious group working towards finding cures for disease. For more information please visit qbi.uq.edu.au/walkergroup and walkerneurolab.org.

A postdoctoral position in cell biology and neurodegenerative diseases is available in the lab of Dr. Michael Ward, National Institute of Neurological Disorders and Stroke (NINDS), Neurogenetics Branch, in Bethesda MD. The Ward lab utilizes human iPSC-derived neurons to study basic mechanisms of neurodegeneration. By combining forward-genetics, proteomics, and molecular/biochemical techniques, we seek to identify converging disease pathways that underlie inherited neurodegenerative diseases. In parallel, we pursue complimentary drug discovery approaches using ultra high-content small molecule screens with colleagues in the National Center for Advancing Translational Sciences (NCATS).

A NIH funded postdoctoral position is available in the laboratory of Benjamin Wolozin to study the role of RNA binding proteins, RNA metabolism and RNA granules in the pathophysiology of neurodegenerative diseases. The postdoctoral fellow will investigate how these processes are regulated, and how dysfunction contributes to disease. The studies will use phase separation biology, cell biology, imaging, optogenetics, proteomics, systems biology and RNAseq. The studies will take advantage of our finding that reducing the RNA binding protein TIA1 delays progression in a mouse model of tauopathy (Apicco, et al, Nature Neuro., 21(1):72-80, PMID: 29273772.)

A research lab at the University of Central Florida Medical College invites you to apply for post-doctoral associate position. Research in the lab is focused on the genetic and molecular mechanisms of neurodegeneration in amyotrophic lateral sclerosis and Parkinson’s disease. Our team has published our findings in Acta Neuropath, EMBO J, the Journal of Clinical Investigation, PLoS Genetics, and PNAS. Post-doctors being recruited will help validate the pathogenic role of genetic mutations newly discovered in the lab using cell culture and animal models. The research lab is located at the UCF Burnett School of Biomedical Sciences at the Lake Nona campus. Researchers who have recently obtained their PhD degrees and seek to further develop their academic career are encouraged to apply for the positions. Please email your CV to Dr. Xugang Xia at [email protected]

The Yang lab also studies pathogenic roles of astrocyte dysfunction in neurological diseases/disorders, such as fragile x syndrome (FXS) and amyotrophic lateral sclerosis (ALS). The lab employs novel genetically modified mouse tools, in combination with primary astrocyte and neuronal cultures, imaging, electrophysiological and biochemical/molecular techniques. The candidate must be able to handle rodents and are familiar with biochemical techniques and prior knowledge of neurodegenerative diseases is desirable. It is expected that the candidate should have a recent PhD (less than 2 years) in Neuroscience/Genetics/Cell Biology/Biochemistry or equivalent and is able to communicate well with others. To apply, please send your CV (via e-mail) including all past education and training, a brief description of research interests, list of publications and other scientific activities as well as names and e-mail addresses of three references to Dr. Yongjie Yang at: [email protected].

A postdoctoral position is available at Cornell University to study lysosomal dysfunction and neurodegeneration in ALS and FTLD. Highly motivated individuals with a strong background in cell biology or mouse genetics and an interest in neurodegenerative diseases are encouraged to apply. Please visit http://hu.wicmb.cornell.edu/ for more details and send your CV and 3 letters of references.

The Cedars-Sinai Regenerative Medicine Institute has a Research Postdoctoral position available to study the molecular mechanisms of neurodegeneration, with particular focus on axon degeneration in inherited peripheral nerve diseases, including demyelinating peripheral nerve disease. Candidate must be experienced with performing techniques ranging from neuronal and stem cell culture, molecular biology and bioinformatics (RNA-seq, exome seq), biochemistry and cell biology.

The Postdoctoral Scholar position in the laboratory of Steven Finkbeiner involves a collaboration between Verily Life Sciences and will focus on developing models and assays for investigating mechanisms of neurodegeneration. The ideal candidate will have experience in human iPSC culture and neuron differentiation, a strong molecular biology background and analytic skills with experience of imaging analysis software and statistical analysis programs.

The focus of the laboratory is to study gene therapy approaches for the treatment of neurodegenerative diseases such as lysosomal storage diseases (GM1-gangliosidosis and Tay-Sachs disease), amyotrophic lateral sclerosis (ALS), Huntington’s disease, and brain tumors. The position requires attention to detail, good communication, strong skills in experimental design and troubleshooting, an ability to work independently. The focus of this position is to investigate systemic AAV gene therapy approaches for Tay-Sachs disease using novel AAV capsids and vector designs.

The primary responsibility of the post-doctoral fellow will be to conceive, design, and analyze studies pertaining to the effect of neurodegenerative disease on structural (e.g., volumetric imaging and diffusion tensor imaging [DTI]) and functional (e.g., blood oxygen level dependent [BOLD] imaging and arterial spin labeling [ASL]) brain organization. Anticipated activities entail development and implementation of new analytic strategies to facilitate understanding of disease in the human brain, integration of large multi-modal imaging datasets, and analysis of the relationship between brain imaging markers and cognition or clinical status. Strong written communication skills are required. Attention to detail, organizational capability, and the ability to handle multiple concurrent tasks are essential. The post-doctoral fellow is expected to be able to work independently as well as part of a team in a fast paced environment.

The Single Motor Unit Laboratory (SMPP) strives to understand how the nervous system controls individual motor units within a muscle so as to enable the generation of muscle force. Seeks to investigate the role of intrinsic properties of motoneurons that innervate relevant muscle fiber populations in providing such control under normal conditions and following such illnesses as stroke, spinal cord injury (SCI) and amyotrophic lateral sclerosis (ALS). The PostDoc Fellow will be responsible for the design, execution and interpretation of experiments within a laboratory team environment and a larger laboratory research program of engineers, physical therapists and neuroscientists focused on sensory motor performance and rehabilitation within a major, nationally leading Academic Rehabilitation Hospital.

A postdoctoral position is available at Cornell University to study lysosomal dysfunction and neurodegeneration in ALS and FTLD. Highly motivated individuals with a strong background in cell biology or mouse genetics and an interest in neurodegenerative diseases are encouraged to apply.

The Single Motor Unit Laboratory (SMPP) at the Rehabilitation Institute of Chicago (RIC) seeks to investigate the role of intrinsic properties of motor neurons that innervate relevant muscle fiber populations in providing such control under normal conditions and following such illnesses as stroke, spinal cord injury (SCI) and amyotrophic lateral sclerosis (ALS). The PostDoc Fellow will be responsible for the design, execution and interpretation of experiments within a laboratory team environment and a larger laboratory research program of engineers, physical therapists and neuroscientists focused on sensory motor performance and rehabilitation within a major, nationally leading Academic Rehabilitation Hospital.

The Cedars-Sinai Regenerative Medicine Institute has a Research Postdoctoral position available to study the molecular mechanisms of neurodegeneration, with particular focus on axon degeneration in inherited peripheral nerve diseases. The primary focus of the candidate will be working with patient derived iPS cell lines, genetically engineering them using CRISPR technology, molecular and genomic characterization including exome sequencing, and differentiating them into motor neurons and Schwann cells to investigate cell replacement therapies for patients.

Postdoctoral opportunities are available in Dr. Shuying Sun’s laboratory at Johns Hopkins University School of Medicine. The Sun lab is interested in deciphering the RNA processing pathways altered by the ALS-causative mutants, identifying inhibitors of neuron toxic factors using various high-throughput screening platforms, and developing novelCRISPR technique-based therapeutic strategies.

A Post-Doctoral Research Associate position is available immediately to study the mechanisms underlying the abnormal amyloid beta-peptide formation and neuronal cells death observed in the central nervous system (CNS) of Alzheimer’s disease and amyotrophic lateral sclerosis (ALS) patients using both animal models and cultured cell systems.

A Postdoctoral Researcher position is available immediately at the Children’s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, to study the molecular mechanisms of human neurodegenerative diseases such as ALS and polyglutamine expansion diseases. The candidate will work with mammalian neuronal culture and drosophila models of ALS and other related human neurodegenerative diseases.

Various postdoc opportunities in ALS, FTD, and neurodegeneration research are available through several labs at University of Florida’s Center for Translational Research in Neurodegenerative Disease, including:

The VIB-KU Leuven Center for Brain and Disease Research (Belgium) is searching for a Principal Investigator with research goals in neuroscience, neuronal disease and/or technology related to seuroscience to join their faculty. The center currently hosts 17 groups, addressing a broad set of questions in central and peripheral nervous system development and function, neuronal and neurodegenerative disease. Approaches range from protein biochemistry, single cell analysis, genetics, computational biology, neuronal cell biology, to neural circuit function and plasticity, while models include fly, zebrafish, mouse and pluripotent human cell systems. This position comes with full salary and core funding (internationally competitive > 1 million EUR package depending on experience) that is renewable for multiple additional 5-year periods. Research groups in the center also have access to state-of-the-art research and top-notch support core facilities, and attract talented PhD students and postdocs from across the world.

We are seeking a motivated Principal Research Associate to join a team of neuroscientists dedicated to developing novel therapies for diseases of the nervous system. The primary responsibility of this individual will be to validate new therapeutic targets for the treatment of amyotrophic lateral sclerosis (ALS) and additional CNS indications under consideration. The successful candidate will have experience with a variety of in vivo and in vitro experimental techniques.

We are seeking an experienced scientist to join Biogen’s Biologics Drug Discovery Team, and contribute to our mission to design, optimize, and develop important protein therapeutics to improve the lives of patients with neurodegenerative disease. In this role, you will jointly lead a cross-functional effort to identify and validate novel methods for enhancing delivery of protein biologics to the central nervous system (CNS).

We are seeking a Research Principal Scientist to join a vibrant and growing group currently focusing on developing new and effective therapeutics for neurodegenerative diseases, migraine and neuropathic pain. This position is within the Neuroscience Therapeutic Area, a key component of the Discovery Research unit at Amgen’s site in Cambridge, MA. The Principal Scientist will focus on in vivo model test systems and the development and validation of mechanism based pharmacodynamic measures supporting characterization and pipeline advancement of novel CNS therapeutics.

The successful candidate will be a member of the West Point Pharmacology Department, a department that provides in vitro and in vivo pharmacology solutions to support a wide variety of neuroscience, infectious disease, and cardio-metabolic programs.

The Department of Cell Biology and Physiology and the Neuroscience Center at the University of North Carolina at Chapel Hill invite applications for an open-rank, tenure-track/tenure eligible faculty position. Research areas of particular interest include Alzheimer’s disease, neurodegeneration, pain, glial biology and glial diseases, but outstanding work in any area of neuroscience will be considered.

At the Jena University Hospital (JUH), Institute of Human Genetics (Director Prof. Dr. Christian Hübner), application are invited for a Professorship (W2 with tenure track to W3) for Cell Biology of Neurodegenerative Diseases. The person to be appointed will represent the subject in research and teaching. There is also the possibility to participate in medical services. It is expected that the appointee strengthens the faculty’s research foci.

The Département de neurosciences at the Université de Montréal invites applications for a faculty position at the assistant or associate level, in Systems/Computational Neuroscience. We are seeking candidates who use experimental and/or computational approaches to study how large-scale distributed brain networks implement behavioural-level phenomena such as sensorimotor control and decision-making, with a particular emphasis on system-level learning mechanisms. Ideal candidates will either combine multi-electrode, multi-area neurophysiological studies in behaving animals (in particular non-human primates) with sophisticated computational modeling of brain function, or alternatively, will use predominantly computational approaches to study how biologically realistic large-scale and recurrent network models simulate behavioral-level phenomena. The Département de neurosciences offers state of the art laboratory space and animal facilities for rodent and non-human primates research.

California Institute for Regenerative Medicine (CIRM) is looking to hire a talented individual to join the Therapeutics Team as a Project Manager. The mission of the CIRM Therapeutics Team is to recruit and enable the development of innovative clinical stage regenerative medicine / cell therapy programs to address the unmet medical needs of patients. The Project Manager reports to the VP of Therapeutics and will coordinate operations of the Therapeutics Team in order to accomplish this mission. The Project Manager will manage the development and execution of project team strategy and will optimize the team’s effectiveness in achieving project objectives in alignment with the stated quarterly and annual goals of that team.

The Rockefeller University seeks a Research Assistant to join Laboratory of Molecular Biology. The Research Assistant will contribute to a project examining the molecular mechanisms of neurodegenerative and psychiatric disorders. The Research Assistant will be responsible for performing molecular techniques, including TRAP, RNA-seq, in situ hybridization, and immunohistochemistry, to examine cell type specific gene expression profiles in the mouse brain. Will complete rodent surgeries, behavioral assays, and functional imaging of brain immunohistochemistry. Will be responsible for maintaining genetically altered mouse lines and completing other routine laboratory duties as needed.

This is an Exciting opportunity at Boston Children’s Hospital to support a cutting edge developmental neuroscience laboratory using emerging techniques in single cell RNA sequencing (scRNAseq) to understand the molecular mechanisms of motor neuron diseases, including eye movement disorders and amyotrophic lateral sclerosis (ALS). (http://www.childrenshospital.org/research-and-innovation/research/labs/engle-laboratory).

We are seeking a research assistant, ideally already skilled in the molecular cloning techniques required for gene targeting in the mouse. The post-holder will support a new group at MRC Harwell and the Senior Investigator Scientist who will run this group, in collaboration with Professor Elizabeth Fisher at UCL, to make gene targeted mouse models for studying neurodegeneration.

The Jackrel Lab is interested in hiring a research specialist. We are looking for recent graduates in Chemistry, Biochemistry, Biophysics, Cell Biology, Genetics, Neuroscience, and related areas. Applicants with more senior experience will also be considered. Responsibilities will include driving an independent research project and assisting in the general organization and running of the lab. We study protein folding and misfolding, and how protein misfolding can lead to neurodegenerative disease. For more information about our research interests, please visit: https://sites.wustl.edu/jackrel/

As a research assistant, the successful candidate will work with protein analysis (Western blot), histological analysis (immunofluorescence, in situ hybridization), analysis of data from in vivo neurotransmitter recordings (glutamate, dopamine recordings) and cytological analysis (immunofluorescence). The source of these samples will be from cell lines, animal models and human samples. The applicant will work close with patients and perform skin biopsies, blood sampling and lumbar punctures to obtain working material. The applicant will be responsible for analyzing these samples according to their respective protocols and the analyses are documented and stored in structured and easy to follow way.

Applications are invited for a Research Assistant role to work on a collaborative project between the groups of Professor David Klenerman and Professor Maria Grazia Spillantini to study the molecular basis of neurodegenerative disease.

BlueRock Therapeutics is a next-generation regenerative medicine company focused on breakthrough treatments and new horizons in medicine. BlueRock Therapeutics’ platform is based on state of the art pluripotent stem cell engineering tools and expansion technology. The company represents a strategic partnership between Bayer and Versant Ventures, and has been granted access to one of the largest-ever Series A financings in biotech.

Nuredis, Inc. discovers and develops small molecule therapies for a group of inherited neurodegenerative and neuromuscular diseases, aiming to treat the cause of disease rather than just managing symptoms. Nuredis was founded in 2016 based on technology licensed from Stanford, with facilities in Menlo Park. We are currently seeking self-driven, intelligent individuals to add their complementary talents to our highly-motivated team.

The Center for Genomics of Neurodegenerative Disease at the New York Genome Center is looking for a well-organized, methodical, and highly motivated Research Associate. This is an exciting opportunity to become part of a dynamic group that is investigating the interactions between motor neurons and glial cells in ALS pathology using hiPSC cell-based models combined with next generation sequencing and CRISPR technology. Our particular focus is to examine the transcriptional, translational, and functional impact of causative ALS mutations in a cell type specific manner. The individual will interface with the Director and key scientific staff to assume responsibility for hiPSC culture, differentiation, functional assays, and RNA harvesting for NGS. The Research Associate will be part of an interdisciplinary team working in a fast-paced environment.

The position is for a full time Staff Research Associate to assist the PI in neuropathology research that investigates the pathogenesis of Alzheimer’s disease, frontotemporal dementia, and related disorders at UCSF Mission bay campus. The Staff Research Associate is expected to be open to learning new methods. One year of relevant laboratory experience including laboratory histology (embedding, cutting, immunohistochemistry, and coverslipping).The position represents an excellent opportunity to further basic laboratory and research skills in a dynamic clinical neuroscience environment. The successful individual will be an energetic, team player, self-directed learner with a keen interest in research.

Under the supervision of the Principal Investigator, the Staff Research Associate II (SRA II) will assist in the performance of behavioral testing and in the analysis of behavioral and neuroimaging data to support research on the neural bases of decision-making in healthy individuals with a family history of frontotemporal dementia. Specific techniques utilized in these studies will include online computer-based testing, task-based functional MRI, psychophysiology, voxel-based morphometry, functional connectivity, and computational modeling of behavior.

We are currently recruiting for a Research Associate I with some basic computational skills and/ or cell culture experience with the desire to learn and work on a multi-faceted project with diverse roles. The person in this position will work with iPSC from patients with Amyotrophic Lateral Sclerosis with the goal to elucidate molecular mechanisms of ALS and to help devlop platforms for drug discovery.

We are looking to recruit a talented and motivated Research Associate to join our highly dynamic neuroscience team. The successful candidate would work on the understanding of neurodegenerative diseases and the discovery of novel therapeutic targets and neuroprotection strategies. In addition to our commitment to multidisciplinary, cutting-edge research, we are committed to mentoring, supporting, and encouraging our team members to grow scientifically, take initiatives, bring new ideas, and play a leading role in our research, which is an important part of our culture and the secret to our success. Candidates who aspire to become part of an innovative and scientifically inspiring environment, with unlimited resources and state-of-the-art facilities and technologies, who enjoy collaborating within and outside of a team, have a passion for scientific discovery, face challenges with a positive attitude, can multitask and work independently, and are dedicated to high quality research, are encouraged to apply. The ideal candidate will be able to fulfill the following key responsibilities and will meet the following requirements:

The Howard Hughes Medical Institute is seeking a highly motivated Research Specialist to join Dr. J. Paul Taylor’s group at St. Jude Children’s Research Hospital. The primary focus of this position will be the use of Drosophila melanogaster as a tool to investigate the molecular genetics of neurological diseases.

Incumbent will assist with new metabolic targets to treat neurodegenerative disease. Under general supervision, assist the principal investigator and laboratory members in developing novel techniques and models to study the intersection between mitochondrial metabolism and neural physiology. Research duties will include assisting with animal handling, tissue harvest, dissections, and primary neural cell preparations. Additional responsibilities will include biochemical assays (immunoblot analysis ,subcellular fractionation), molecular biology (qRT-PCR and genetic manipulation of cells with siRNA, viral vectors, or CRISPR technology), and specialized metabolic assays (Seahorse XF analysis, plate-based enzymatic assays). Preparation of samples for high-content imaging or mass spectrometry analysis will also be required. Further duties will include general lab maintenance responsibilities, such as organization and management of supplies, chemical reagents, and animals.

The Svendsen Laboratory at Cedars-Sinai Medical Center, Regenerative Medicine Institute is looking for personnel to join our dynamic group. The ideal incumbent should have experience in managing and analysis of large datasets using programming languages such as Python and R, and an interest in working hands on with stem cells and organ-on-chip technology with a focus on research in neurodegenerative diseases (Brain-on-Chip). Ideal candidate will also have experience in machine learning approaches for use in automation of laboratory equipment and analysis of complex bioinformatic datasets. Working with the P1 and scientists, the Research Associate II (RA11) performs a variety of routine experimental protocols and procedures to support the objectives of one or more laboratory research projects in a specific area of research, including the Brain-on-Chip program. RAII is responsible for the generation and curation of acquired data, implementation of analysis programs, and generation of scripts to assists in laboratory activities and research aims. RAH is responsible for general laboratory activities including maintenance of reagents, ordering and stocking of supplies. RA11 keeps accurate and detailed records of experiments and results. RAH assists in the operation of specialized equipment and machinery, including the culture of human stem cell derived tissues. Observes safety standards and procedures. This position may include supervisory responsibilities. Daily Duties will include the following: – Performs a variety of routine laboratory tasks and procedures. – Works with laboratory staff to develop and implement analysis frameworks for use in biomarker and therapeutic target discovery – Keeps accurate and detailed project records of experiments and results. – Maintains lab equipment and related records. – Transports, processes and logs samples. – Maintains computer database with relevant information – implements scripts for the analysis of complex imaging and multi-omic analysis datasets. – Performs lab maintenance duties, including glassware cleaning and sterilization, – Maintains stocks of general lab materials, and places orders for lab equipment and supplies. – Assists new students and fellows at the laboratory. – Assists in the operation of specialized equipment and machinery. – Observes and complies with safety standards arid procedures. – Histology and Microscopy – Sectioning of tissue specimens – Staining of tissue specimens to include special stains and INC. Additional Information: Scheduling flexibility including evening, weekend and holiday rotation commitment is required. Travel may be required.

Under the direction of the PI or research staff, the Research Associate will help us achieve our research goals by performing and managing tissue culture projects in the lab. The primary focus will be human fibroblasts and stem cell culture, but primary neuron culture from animal models will also be performed.

The research group of Professor Ernest Fraenkel seeks a talented scientist to participate in an unprecedented study of the neurodegenerative disease ALS. Working with researchers at clinical and academic institutions across the United States, we are gathering data on approximately 1,000 ALS patients and controls. Induced pluripotent stem cell (iPSC) lines are being derived from each individual and these are being used to generate motor neurons for a wide range of omic studies. Our collaboration seeks to identify different subtypes of the disease, identify correlations between molecular pathways and clinical symptoms, and propose therapeutic strategies.

A Research Associate position in the laboratory of Dr. Fen-Biao Gao at the Department of Neurology is available to help study frontotemporal dementia using induced pluripotent stem cells (iPSCs). Candidates with substantial research experiences in molecular biology (such as western blot, cloning etc.) and cell biology (such as stem cell culture and differentiation, or mammalian cell cultures in general) are encouraged to apply. Candidates with PhD or MD degrees will be considered as well.

The Staff Research Associate II (SRA II) position is for a full time lab technician (Research Assistant) to assist the Principal Investigator (PI) in neuropathology research that investigates the pathogenesis of Alzheimer’s disease, frontotemporal dementia, and related disorders at UCSF Mission bay campus (see http://grinberglab.ucsf.edu).

Cytokinetics is a late-stage biopharmaceutical company focused on discovering, developing and commercializing first-in-class muscle activators as potential treatments for debilitating diseases in which muscle performance is compromised and/or deteriorating. With an unmatched understanding of muscle biology and mechanics of muscle performance, the company is developing small molecule drug candidates specifically engineered to increase muscle function and contractility. Working collaboratively, Cytokinetics’ dedicated employees are focused on advancing novel mechanism therapeutics to dramatically improve the lives of patients. With purpose and passion, we have committed to make an important impact on serious medical illnesses.

They Meyer laboratory is focusing on research in life-threatening Neurodegenerative and Neurological Disorders such as Amyotrophic Lateral Sclerosis and Spinal Muscular Atrophy, Rett Syndrome and Batten Disease. We investigate disease mechanisms using state-of-the-art in vitro models and reprogramming techniques. Our efforts are motivated by finding a treatment that can be translated to the clinic. Using gene therapy, we have successfully translated several of our approaches to the clinic and continue to work hand-in-hand with clinicians at the hospital. Our laboratory is looking for a highly motivated, Research Associate with minimum 2 years of experience to join our young and energetic team. The position does not require a background in gene therapy, but experience in performance of ELISAs and ELISpots, or previous experience working in a clinical laboratory, would be of advantage. The candidate will perform research experiments using patient samples, document and maintain exact records of experiments, prepare laboratory reports and assist with analyzing data.

We are seeking a Research Associate to join the Neuro-Muscular group at CRISPR Therapeutics, an exciting, fast growing and well-financed company. The successful candidate will be an integral part of a team whose aim is to discover the next generation of genetic therapies for serious neurodegenerative diseases. The position requires enthusiasm, passion, attention to detail and a desire to create new medicines for patients.

One Research Associate position is currently available at the Laboratory of Neuro Imaging in the area of neuroimaging genetics, involving the development of algorithms for the identification of novel multimodal (imaging and genetic) feature combinations and models that explain such imaging-genetic interactions and facilitate diagnoses and prognoses in neuropsychiatric, neurodegenerative, and neurodevelopmental brain disorders. Additional responsibilities will be to train student researchers and interact with other laboratory assistants on common projects. Other key responsibilities will be documentation of procedures using word processing, data base and web-based applications, and supervised statistical analyses, figure and table preparation for various manuscripts and scientific presentations. The successful candidate will have a strong background in multimodal brain image analysis, large-scale genetic association study and statistical modeling. Knowledge of neuroanatomy and basic neuroscience, computer programming experience (working knowledge of Linux, Matlab, R, Python, C/C++, etc.) and excellent communication and writing skills are desired. Experience on database, bioinformatics, graphical models, dimensionality reduction, and machine learning is desirable.

Voyager Therapeutics is a gene therapy company developing life-changing treatments for severe neurological diseases. Voyager is committed to advancing the field of AAV (adeno-associated virus) gene therapy through innovation and investment in vector optimization and engineering, dosing techniques, as well as process development and production. The company’s pipeline is focused on severe neurological diseases in need of effective new therapies, including advanced Parkinson’s disease, a monogenic form of amyotrophic lateral sclerosis (ALS), Friedreich’s ataxia, Huntington’s disease, spinal muscular atrophy (SMA), frontotemporal dementia and Alzheimer’s disease and severe chronic pain.

The Svendsen Laboratory at Cedars-Sinai Medical Center, Regenerative Medicine Institute is looking personnel to join our dynamic group. The ideal incumbent should have experience in managing and analysis of large datasets using programming languages such as Python and R, and an interest in working hands on with stem cells and organ-on-chip technology with a focus on research in neurodegenerative diseases (Brain-on-Chip). Ideal candidate will also have experience in machine learning approaches for use in automation of laboratory equipment and analysis of complex bioinformatic datasets. Working with the PI and scientists, the Research Associate I (RA I) performs a variety of routine experimental protocols and procedures to support the objectives of one or more laboratory research projects in a specific area of research, including the Brain-on-Chip program. RA I is responsible for the generation and curation of acquired data, implementation of analysis programs, and generation of scripts to assists in laboratory activities and research aims. RA I is responsible for general laboratory activities including maintenance of reagents, ordering and stocking of supplies. RA I keeps accurate and detailed records of experiments and results. RAH assists in the operation of specialized equipment and machinery, including the culture of human stem cell derived tissues. Observes safety standards and procedures. This position may include supervisory responsibilities. Daily Duties will include the following: – Performs a variety of routine laboratory tasks and procedures. – Works with laboratory staff to develop and implement analysis frameworks for use in biomarker and therapeutic target discovery – Keeps accurate and detailed project records of experiments and results. – Maintains lab equipment and related records. – Transports, processes and logs samples. – Maintains computer database with relevant information – implements scripts for the analysis of complex imaging and multi-omic analysis datasets. – Performs lab maintenance duties, including glassware cleaning and sterilization, – Maintains stocks of general lab materials, and places orders for lab equipment and supplies. – Assists new students and fellows at the laboratory. – Assists in the operation of specialized equipment and machinery. – Observes and complies with safety standards arid procedures. – Histology and Microscopy – Sectioning of tissue specimens – Staining of tissue specimens to include special stains and INC. Additional Information: Scheduling flexibility including evening, weekend and holiday rotation commitment is required. Travel may be required.

The Svendsen Laboratory at the Cedars-Sinai Regenerative Medicine Institute is looking 1hr personnel to join our dynamic group. The incumbent should have an interest in the basic science of stem cells and neuroscience. By understanding how the cells grow and differentiate we will be able to produce a better cell for transplantation and develop techniques for disease modeling. The laboratory technician will, under the direction of the P1, lab manager and project scientist, assist in the conduct of research in Amyotrophic Lateral Sclerosis (ALS).

Dr. Gretchen Thomsen’s Laboratory at the Cedars-Sinai Regenerative Medicine Institute is looking for personnel to join our dynamic group. The incumbent should have an interest in the basic science of stem cells and animal research. The laboratory technician will, under the direction of the PI and lab manager, assist in the conduct of research in amyotrophic lateral sclerosis (ALS) and traumatic brain injury (TBI).

The postholder will join the ViTAL consortium of researchers working on Amyotrophic Lateral Sclerosis (ALS), funded by the charity TARGET-ALS. They will identify toxic elements that are secreted through exosomes in ALS, and determine their role in ALS. (Fixed-term until 30 June 2018)

This Research Associate position will be at Dr. Jun Wang’s Speech Disorders & Technology Lab. The focus will be, but not limited to, dysarthric speech recognition and analysis, and automatic speech recognition for clinical purpose. Under the supervision of Dr. Wang, the successful candidate will work in a collaborative environment for speech recognition and signal processing experiments and writing for publication. Expected focus will be on speech data that are collected from patients with amyotrophic lateral sclerosis (ALS) or after laryngectomy. Participation in grant writing, conference presentations, guest lecture, and student training in the lab are encouraged.

Under the supervision of a Clinical Research Supervisor or Principal Investigator (PI) at the UCSF Memory and Aging Center, the Research Coordinator will act as a study coordinator for clinical studies of normal aging, Alzheimer’s disease, Frontotemporal dementia and other forms of neurodegenerative disease, and may receive training and development to prepare and advance for journey-level work at the next level within the series.

We are seeking a coordinator for a multi-site consortium using a novel approach to neuroimaging of neurodegenerative diseases. The lead site is Penn, and participating sites include Mayo Clinic, UCSF, MGH and Northwestern. All sites have specialized neuroimaging equipment, and we will be using advanced neuroimaging tools developed locally and in collaboration with the Human Connnectome Project (HCP) to analyze the acquired data. The successful candidate also will be responsible for managing the Penn site.

The Research Programs Specialist at the Weston Brain Institute will be responsible for developing the initiative’s scientific knowledge, running granting programs, and managing a portion of the Institute’s grant portfolio. Candidate should have research experience in one or more neurodegenerative diseases of aging, including ALS and FTD with a relevant PhD or MD. This position is located in London, UK and reports into the global operations in Toronto, Canada.

At Tiaki, we discover first-in-class small molecule therapeutics to provide disease modifying benefit to patients suffering from age-related dementias. To accomplish this we focus on discovering drugs that return chronically activated microglia, found in neurodegenerative conditions, to CNS protective microglia found in the healthy brain. Tiaki is a venture-backed start up located at Lab Central.

AveXis, Inc., a Novartis Company, is a clinical-stage gene therapy company, dedicated to developing and commercializing novel treatments for patients suffering from rare and life-threatening neurological genetic diseases. Our initial product candidate, AVXS-101, is our proprietary gene therapy product candidate currently in development for the treatment of spinal muscular atrophy, or SMA, Type 1, the leading genetic cause of infant mortality, and for the treatment of SMA Type 2. The U.S. Food and Drug Administration, or FDA, has granted AVXS-101 Orphan Drug Designation for the treatment of all types of SMA and Breakthrough Therapy Designation, as well as Fast Track Designation for the treatment of SMA Type 1. In addition to developing AVXS-101 to treat SMA Type 1 and Type 2, we also plan to develop other novel treatments for rare neurological diseases, including Rett syndrome (RTT) and a genetic form of amyotrophic lateral sclerosis (ALS) caused by mutations in the superoxide dismutase 1 (SOD1) gene.

Inscopix is looking for a talented neuroscientist with a strong background working with rodent models of neurodegenerative disease who is interested in pursuing groundbreaking brain science in a highly-motivating and fast-paced entrepreneurial environment. You will have unique opportunities to work in close collaboration with an interdisciplinary team of driven neuroscientists, physicists, engineers, and data scientists. If you are looking for an opportunity that immerses you in 21st century neuroscience, we want to hear from you!

Ready to join a team committed to moving gene therapies into the clinical and commercial settings for patients and families devastated by rare neurological genetic diseases? AveXis is advancing cutting-edge science to treat rare and life-threatening genetic diseases starting with our clinical-stage, proprietary gene therapy candidate, AVXS-101. We are in the midst of an incredible journey, and are looking for passionate individuals to join us on this important mission.

The Institute for Neurodegenerative Diseases (IND) at the University of California, San Francisco (UCSF) is seeking a molecular/cell biologist to design, develop and validate novel tools for the study of neurodegenerative diseases. The director of the IND is Nobel Laureate Dr. Stanley Prusiner.

The researcher will be devoted to the development of advanced techniques of in vivo Clinical Biochemistry, in particular metabolic (MR spectroscopy), microstructural and molecular (diffusion tensor imaging) and functional (fMRI) imaging, for the study of the central nervous system and neuromuscular system. The research activity will be applied to inflammatory, neurometabolic, neurodegenerative and neoplastic disorders, aimed to a) the identification of early diagnostic and prognostic markers and surrogate markers of treatment; b) the characterization of brain activations patterns; c) optimization of structural and functional connectivity analysis.

This scientist will lead an early-stage, hit-to-lead drug development project for Amyotrophic Lateral Sclerosis (ALS). Initially, he or she will conduct in-house experiments and work with external collaborators and CROs to establish a structure-activity relationship and guide the associated medicinal chemistry work. This individual will advance the project into the lead optimization phase, including ADME and in vivo efficacy. The requirements include a PhD in the biomedical sciences, competency in mammalian cell culture and assay development, background in neuroscience research, and industry experience in CNS drug development. Salary will be commensurate with experience; BrainXell offers full health and dental benefits.

We are currently seeking a highly motivated, experienced scientist to join the stem cell group in the Neuroscience department to aid in target discovery and validation in the areas of psychiatry and neurodegeneration.

We are looking for an experienced BS or MS degreed research scientist to join the Neuroscience department. The candidate will play a hands-on role in a highly collaborative team responsible for research on neurodegenerative diseases. You will conceive, conduct, and analyze experiments to identify and evaluate compounds or biologics in various assays and cellular models. These include but are not limited to bioanalytical and biochemical assays, human ES/iPS derived neuronal models, and analysis of tissue samples.

We are looking for an experienced research scientist to join the Neuroscience department. The scientist will assume a hands-on role in a team responsible for an early drug discovery project for a neurodegenerative disorder. The scientist will conceive, conduct, and analyze experiments to identify and validate novel targets and low molecular weight modulators. In vitro and ex vivo models, including hPSC-derived neuronal platforms, and other molecular and cell biology techniques, will be heavily utilized within projects. Excellent communication and teamwork will be critical.

We are seeking an experienced and highly motivated neurobiologist to contribute to our research team at our facility in Cambridge, Massachusetts. This is an ideal position for an individual with a strong background in in vivo experimental methods and readouts, who thrives in a team-oriented, fast-paced, and cross-disciplinary start-up biotech environment. The individual will work in the laboratory and be responsible for experimental execution and data analysis for research studies supporting therapeutic programs and platform discovery research in neurodegenerative disease areas. The successful candidate will have extensive prior experience in drug discovery in neurodegenerative diseases including hands-on techniques in stereotaxic surgery, in vivo behavioral assays of rodent models, CNS tissue dissection, and tissue analysis (such as RT-qPCR, western blot and ELISA).

We are seeking highly motivated individuals with BS/MS degrees to join a dynamic research group in the Neurosciences Division at Novartis Institutes for Biomedical Research in Cambridge, MA. The individual will conduct hands-on research directed towards understanding the molecular mechanisms underlying neurodegenerative disorders, and identify and evaluate small molecule compounds or biologics that target key pathogenic events in these diseases. Proficiency in the use of current molecular biology and biochemical techniques is expected. Extensive experience in mammalian cell culture, viral transduction techniques as well as gene knockdown technology and stable cell line generation are preferred. Candidates should have strong data analysis and communication skills. In addition to the above expertise candidates are expected to gain new skills based on evolving project needs and demands.

We seek a talented and highly collaborative computational biologist that has extensive experience with 1) RNA Sequencing for transcriptome analysis, and 2) applying short and long read DNA-Seq methods for mutation mapping and viral genome characterization, and a keen interest in applying these methods to the discovery and development of novel therapeutics for the treatment of neurodegenerative diseases.

AC Immune is seeking a highly qualified Research Scientist. The candidate must possess scientific background in structural biophysics and protein dynamics in neurodegenerative diseases and a clear record of accomplishment in an academic or a commercial setting. S/he will work on the discovery and characterization of PET radiotracers for the diagnosis of neurodegenerative disorders. Previous experience in neuroscience and neurodegenerative disorders, notably ALS and FTD along with TDP-43, is an advantage. S/he must have demonstrated their ability to make significant discoveries in an academic setting or bring a research product to a clinical stage.

Proneurotech, Inc. is a new, privately-held biopharmaceutical company focused on the discovery and development of novel neuroprotective drugs that prevent axon degeneration for the treatment of neurologic and ocular diseases.

Amgen Neuroscience is looking for a motivated cell and molecular biologist to be a driver of our efforts to develop therapies for neurodegenerative disease. As the field of neuroimmunology holds great potential for neurodegenerative disease treatments, the candidate will bring a perspective on the innate immune system to construct assays and uncover decision-driving human biology. This position is for the dedicated experimentalist who will work in a multidisciplinary team as part of our pre-clinical research. Core areas of focus will be translating genetics and human biology observations into both in vitro and in vivo systems to understand modifiers of neurodegenerative pathology. Also, this position will be charged with exploring the emerging target space of the immune system in the brain via functional genomics (siRNA, shRNA, CRISPR/Cas9, and chemogenomic screens), proteomics, and transcriptomics.

Voyager Therapeutics is seeking an experienced and highly motivated neurobiologist to contribute to our research team at our facility in Cambridge, Massachusetts. This is an ideal position for an individual with a strong background in in vivoexperimental methods and readouts, who thrives in a team-oriented, fast-paced, and cross-disciplinary start-up biotech environment. The individual will work in the laboratory and be responsible for experimental execution and data analysis for research studies supporting therapeutic programs and platform discovery research in neurodegenerative disease areas. The successful candidate will have extensive prior experience in drug discovery in neurodegenerative diseases including hands-on techniques in stereotaxic surgery, in vivo behavioral assays of rodent models, CNS tissue dissection, and tissue analysis (such as RT-qPCR, western blot and ELISA).

The Krembil Research Institute at the University Health Network in Toronto Canada is seeking an early to mid career basic scientist in the area of neuroinflammation. Preference will be given to individuals with a research focus on the involvement of innate immunity, including the roles of immune mediators such as microglia and astrocytes, and their expressed cytokines and chemokines, in neurodegenerative diseases affecting the human CNS. The successful candidate will have a PhD or MD/PhD, postdoctoral experience and demonstrated research excellence. The successful candidate will be expected to qualify for an appointment at the Assistant or Associate Professor level (status only) in the appropriate department at the University of Toronto.

The Department of Pathology currently has an outstanding opportunity for a Research Scientist/Engineer 2. Under the general direction of the PI, this position provides comprehensive research to develop biomarkers for the diagnosis and staging of neurodegenerative diseases, and for the evaluation of potential disease modifying agents.

Prevail Therapeutics is a venture capital-backed, New York City-based biotechnology company, with a mission to cure Parkinson’s disease and other neurodegenerative diseases using gene therapy approaches. The primary responsibility is to perform bioanalytical and cell-based assays and to assist our efforts to identify and advance the development of novel targets for neurodegenerative disorders. We are looking for an enthusiastic, self-motivated, hands-on, scientist with excellent interpersonal skills who is comfortable working in an open environment spanning multiple functions. As an early hire at a new company, you will have exposure to senior management, to all activities at Prevail, and you will be influential in championing and developing Prevail’s culture.

Denali Therapeutics is seeking to recruit a Research Scientist/Senior Research Scientist in support of the company’s growing translational biology and biomarker needs. This individual will work in close collaboration with colleagues in the In Vivo group, Research, Development Sciences, and Clinical Development to implement biomarker assays in support of preclinical target engagement studies. S/He would also contribute towards discovery/development of novel biomarkers for target engagement assessment and disease biology.

A Lead Research Specialist position is available in the Center for Neurodegenerative Disease to join a dynamic research environment that uses a wide range of techniques and technologies to study neurodegenerative disease (e.g., Alzheimer’s disease, amyotrophic lateral sclerosis) pathogenesis. The successful applicant will be self-motivated and capable of working both independently and as a member of a team. Responsibilities will include assisting with the procurement and banking of human autopsy brain specimens and with distribution of tissue and biospecimens to investigators. He/she will also share responsibility for histological and immunohistochemical staining of human and rodent tissues. The successful applicant will be familiar with and train users in the proper use of shared laboratory equipment, and will share responsibility for maintaining the laboratory, including monitoring the storage and disposal of hazardous substances, ordering supplies, calibrating and performing routine repair and maintenance of equipment, interfacing with service personnel for equipment repairs, and maintaining and documenting laboratory safety standards. Upon hiring, the employee must complete the Laboratory Safety Training class and undergo immunization against potentially hazardous agents, as required by Emory University policy. Basic computer experience (Microsoft Word, Excel, etc.) and strong organizational and record-keeping skills are essential. Experience with Western blotting, confocal microscopy, tissue sectioning, histology and/or immunohistochemistry is highly desirable.

A full-time position is available in the laboratory of Dr. Corey McMillan in the Department of Neurology at the University of Pennsylvania. This laboratory focuses on translational neuroscience questions related to improving the diagnostic and prognostic biomarkers of related neurodegenerative diseases including amyotrophic lateral sclerosis (ALS) and frontotemporal degeneration (FTD). We also explore genotype and phenotype relationships using a multimodal approach that integrates clinical, imaging, genetic, and biofluid datasets. Applicant responsibilities will include collection of psychometric and imaging data from patients with ALS and/or FTD, preliminary statistical analyses, database management, processing biofluid samples, and administrative coordination with consortia collaborators.

The Howard Hughes Medical Institute is seeking a highly motivated Research Specialist to join Dr. J. Paul Taylor’s group at St. Jude Children’s Research Hospital. The primary focus of this position will be the use of Drosophila melanogaster as a tool to investigate the molecular genetics of neurological diseases.

Calico is inviting applications from biochemists/neurobiologists who are excited to work as part of a research team focused on identifying and targeting pathways involved in neurological diseases and aging. We are looking for a highly motivated and creative person who will focus on studying the underlying biology of protein aggregation and clearance in neurodegeneration and aging. This position will require independent work and the ability to develop and implement biochemical assays and cell-based assays in CNS cell types as well as deploy functional genomic platforms.

A full-time position is available in the laboratory of Dr. Murray Grossman in the Department of Neurology at the University of Pennsylvania. This lab focuses on cognitive neuroscience and clinical questions relating to language, memory, and neurodegenerative disease (e.g., primary progressive aphasia, behavioral variant frontotemporal degeneration, Alzheimer’s). Applicant responsibilities will include the collection and analysis of PET scan data, and the collection and analysis of structural MRI data. This position will provide a strong foundation for individuals interested in continuing their education in graduate or medical school.

A full-time position is available in the lab of Alice Chen-Plotkin in the Department of Neurology at the University of Pennsylvania. Our lab researches neurodegenerative disease, with a particular focus on frontotemporal dementia and Parkinson’s disease. Projects range from studying the basic mechanisms of disease to finding and developing clinically useful tools such as biomarkers. Responsibilities for this position will include assistance with biochemical, molecular biological, and cell biological assays as needed to meet scientific goals. In addition, familiarity with analysis of large genetic datasets is preferred, including knowledge of statistical and computational methods (i.e. familiarity with linear/logistic regression, ability to use R or other statistical tools). All members of the lab are also expected to attend weekly lab meetings and to participate in the educational activities (e.g. journal club) of the lab.

The Institute for Neurodegenerative Diseases (IND) at UCSF, Mission Bay Campus is seeking a Specialist for full-time work to perform and manage research activities in biochemistry and structural biology. The position is in the laboratory of Dr. Daniel Southworth and will support research efforts using cryo-electron microscopy to determine 3D structures of important biological macromolecules associated with human neurodegenerative diseases. Highly motivated candidates capable of independent problem solving and teamwork are encouraged to apply. This position will be part of a collaborative environment with access to state-of-the-art facilities in the Sandler Neurosciences Building on the UCSF Mission Bay campus. A successful candidate will be hired at the Junior, Assistant, or Associate Specialist rank commensurate with experience and qualifications.

The Division of Neuromuscular Disorders is seeking a Research Support Coordinator to join a very active clinical research program with multiple ongoing research studies. The primary focus of the work will be on investigator-initiated research in the fields of amyotrophic lateral sclerosis (ALS) and myasthenia gravis (MG). The research support coordinator will work closely with clinical research coordinators, data manager, statistician, clinical staff and the Principal Investigator.

The laboratory is seeking a motivated and enthusiastic candidate with experience in stem cell culture and molecular biology to support preclinical studies related to Amyotrophic Lateral Sclerosis (Lou Gehrig’s Disease) and pain. Working independently under the direction of the Principal Investigator, the research technician will assist in ongoing translational studies. The major responsibilities will include stem cell culture and differentiation, as well as general molecular biology techniques such as immunohistochemistry, RNA isolation and PCR to analyze the cells of interest. Additional work will include assistance with ordering, laboratory maintenance and animal husbandry.

The laboratory is seeking a motivated individual to join our efforts in exploring disease mechanisms and developing therapeutic strategies for amyotrophic lateral sclerosis and dementia. Under the direction of the Principal Investigator, the research technician will perform laboratory experiments which include DNA and RNA purification, quantitative PCR, gel electrophoresis, Western blots, DNA cloning, immunostaining and preparation of libraries for high throughput sequencing. The incumbent will also be responsible for handling patient samples and genetic testing of neurodegenerative conditions as part of a research project in collaboration with the ALS multidisciplinary clinic. Additional skills include maintenance of cell cultures, ordering necessary reagents to conduct experiments, and participation in joint upkeep of the lab. Experience in mouse handling and surgical procedures is preferred. The candidate will participate to the research activity of the lab and is expected to be fully engaged in the scientific projects, as well as participate to the scientific lab meetings. The individual must pay attention to details, can work independently under minimal supervision, possess good verbal and written communication skills, and work well as part of a team.

Our lab aims at developing and testing a novel pharmacological platform, based on MRI/PET traceable nanoparticles targeted to activated microglia, as a therapeutic approach to track and modulate neuroinflammation in Amyotrophic Lateral Sclerosis. This position will assist scientists in performing scientific research, development and/or clinical tasks of varying complexity. In general, this position will assist in the set up, operation and maintenance of laboratory instruments and equipment, monitoring experiments, making observations and calculating and recording results.

The Maniatis lab iat CUMC is seeking a highly motivated Technician B to work on a project focusing on the role of innate immunity and autophagy pathways on the progression of the neurodegenerative disease Amyotrophic Lateral Sclerosis (ALS). The technician will work closely with colleagues using techniques such as gene expression profiling, in vitro cell culture assays, and in vivo mouse genetics.

A Research Technologist to work in the laboratories of Drs. Brett Morrison and Jeffrey Rothstein in the Department of Neurology. Our laboratories study the pathogenesis of the devastating motor neuron disease, amyotrophic lateral sclerosis (ALS; commonly referred to as Lou Gehrig’s disease). A particular focus is on the role played by oligodendrocytes, a key support cell in the brain that is dysfunctional and degenerates in ALS.

Prize4Life, a non-profit focused exclusively on accelerating the development of treatments for ALS, recipient of the 2011 Prime Minister Award for entrepreneurship and innovation, is looking for a Scientific Officer. We believe that biologists, chemists, engineers, clinicians, software developers and many others can all bring meaningful change to the field of ALS research, and victory over ALS can be, and should be, everyone’s.

VIB and UAntwerp are in search for a dynamic, internationally recognized leader in genetics and genomics to inspire and lead the VIB research centre at the University of Antwerp. The selected candidate will be appointed as scientific director at VIB and will have a research professor appointment (ZAPBOF) as (full) professor at the University of Antwerp.

As Scientist and critical member of the committed Neuro-Immunology team, you’ll help Alector discover and develop novel drugs targeting dementia and other neurological disorders. You will design and prioritize your own experiments and research endeavors to further Alector’s collective scientific understanding. In doing so you’ll apply your scientific insights to grow the company and guide its direction. Your work will be both inside and outside of the lab, and both strategic and hands-on. As an early hire, you’ll be influential in championing and developing Alector’s culture.

Lilly Neuroscience is seeking an associate-level scientist (Bachelors or Masters) to join the Neurodegeneration Team to facilitate its mission of discovering novel medicines for the treatment of Alzheimer’s disease, Parkinson’s disease, and other related neurodegenerative conditions. The individual must possess a keen interest to understand the pathophysiological processes that underlie neurodegenerative conditions such as Alzheimer disease and have an exceptional attention to scientific detail.

The Discovery Research team has an opening for a neuropharmacologist at the Scientist 1 level. The qualified individual should have experience with the use and development of in vitro, ex vivo and in vivo approaches for CNS disorders including multiple sclerosis, neuroinflammation and neurodegeneration. Experience with iPSC models, primary cell screening concepts and/or drug repositioning will be an advantage.

Voyager is seeking a highly motivated neurobiologist to contribute to our research team. This is an ideal position for an individual with a strong background in in vivo experimental methods and readouts, who thrives in a team-oriented, fast-paced, and cross-disciplinary start-up biotech environment. The individual will work in the laboratory and be responsible for experimental execution and data analysis for research studies supporting cutting edge therapeutic programs and platform discovery research in neurodegenerative disease areas. The successful candidate will have extensive prior experience in drug discovery in neurodegenerative diseases and with hands-on techniques in stereotaxic surgery, in vivo behavioral assays of rodent models, CNS tissue dissection, and downstream analysis (RT-qPCR, western blot and ELISA).

Neurology Research at Biogen seeks a highly motivated and experienced associate scientist to join the new initiative on ALS (amyotrophic lateral sclerosis). The Neurology department is responsible for discovery research on pathogenic mechanisms of neurodegenerative disorders and translating these findings into novel strategies for therapeutic intervention. The successful candidate will execute in vivo experiments to support the validation of novel drug targets and the development of small- and large-molecule drugs for the treatment of ALS. A major component of this work will be the assessment of drug candidates in a multiple rodent models, using a wide variety of morphological and functional endpoints, working closely with members of the ALS team as well as multiple internal and external collaborators. You will work in a fast paced, highly collaborative team environment at an exciting period for ALS research.

Neurology Research at Biogen seeks a highly motivated and experienced associate scientist to join the new initiative on ALS (amyotrophic lateral sclerosis). The Neurology department is responsible for discovery research on pathogenic mechanisms of neurodegenerative disorders and translating these findings into novel strategies for therapeutic intervention. The successful candidate will execute in vivo experiments to support the validation of novel drug targets and the development of small- and large-molecule drugs for the treatment of ALS. A major component of this work will be the assessment of drug candidates in a multiple rodent models, using a wide variety of morphological and functional endpoints, working closely with members of the ALS team as well as multiple internal and external collaborators. You will work in a fast paced, highly collaborative team environment at an exciting period for ALS research.

The individual will develop, implement, and qualify innovative analytical solutions for the characterization and testing of ASOs and pharmaceuticals (both off-line and on-line). This work will support process and formulation development and will drive the control strategy. Key areas of focus will be in enhanced impurity monitoring, simple and specific identity testing, and evaluating novel formulations. The primary methods are HPLC/UPLC, MS, and spectroscopy, but the use of other methods is required and should be explored.

The Discovery and Early Development Biomarkers group, part of Biogen’s Research and Early Development department is seeking a highly motivated scientist to join a dynamic team engaged in the discovery and progression of novel biomarkers for neurodegenerative diseases.

We seek an independent neuroscientist focused on identification of new targets for promoting axon regeneration, axon integrity and synapsis. The candidate will (1) be expected with the goal of delivering new targets to the clinic, focusing on multiple sclerosis and other neurodegenerative diseases, (2) apply in vitro and in vivo models to study the underlying mechanisms of degeneration and dysfunction in neurodegenerative diseases, (3) be familiar with cellular and animal models to study the effects of small molecules, antisense oligonucleotides, and antibodies for their roles in regeneration and repair, (4) enjoy membership amongst a highly productive and dynamic research team with many possibilities to collaborate internally and with external academic leaders, and (5) be expected to lead the project, present and publish their findings.

Perform Drosophila neurobiological research to study neuronal function including electrophysiology and imaging. Design and execute experiments that test disease biology and investigate neuronal function in genetic models of neurodegenerative disease in the fly. Conduct hands-on research and interact with other members of the Department of Neurology Research engaged in biomedical and behavioral studies. Perform research involving electrophysiological and imaging techniques in Drosophila.

Neurology Research at Biogen seeks a highly motivated and experienced associate scientist to join the new initiative on ALS (amyotrophic lateral sclerosis). The Neurology department is responsible for discovery research on pathogenic mechanisms of neurodegenerative disorders and translating these findings into novel strategies for therapeutic intervention.

The Biogen Department of NeuroImmunology seeks a highly motivated and keen experimentalist whose primary responsibility is to advance drug discovery and development by performing bench research. The individual will be expected to design studies and execute research aimed at target discovery as well as the development of therapeutic approaches to treat acute neurological indications and chronic neurodegenerative diseases. The individual is expected to function independently and creatively within the context of project teams, drawing on pertinent literature, and to foster collaborations to maximize synergies and cross disciplinary approaches to advance the studies. The work will involve a wide array of in vitro and in vivo techniques and is expected to yield high quality publications.

The Biogen Epigenetics group seeks a highly motivated, creative scientist who will expand capabilities in epigenomic engineering within our Epigenetics and Cell & Gene Therapy groups, in consultation with colleagues in Neurology and Rare Disease groups. This scientist will have interests in the discovery and validation of mechanisms, pathways and potential drug targets for the treatment of neurodegenerative and rare diseases. S/he will create the means for the validation and modulation of targets of interest through the development of epigenomic engineering approaches for the modulation of disease-relevant target genes.

The Biogen Epigenetics group seeks a highly motivated, creative scientist who will expand capabilities in epigenomic engineering within our Epigenetics and Cell & Gene Therapy groups, in consultation with colleagues in Neurology and Rare Disease groups. This scientist will have interests in the discovery and validation of mechanisms, pathways and potential drug targets for the treatment of neurodegenerative and rare diseases. S/he will create the means for the validation and modulation of targets of interest through the development of epigenomic engineering approaches for the modulation of disease-relevant target genes.

The Biogen Department of Neuro/Immunology seeks a highly motivated and keen associate scientist whose primary responsibility is to advance target validation, drug discovery and development. The individual is expected to have mastered a broad range of experimental techniques, preferably having established expertise in the field of neuroimmunology. The individual will be expected to perform with significant independence with respect to designing and executing controlled experiments, analyzing and interpreting results, establishing and executing existing or new protocols/methodologies and recommending modifications. The individual is expected to read pertinent literature and exhibit knowledge of molecular and biological processes, applying their knowledge to propose new ideas and regularly make suggestions for creative solutions to technical challenges. The individual is expected to have strong written and verbal communication skills, preparing and delivering oral presentations, posters, draft research reports and contributing to manuscripts.

Biogen is seeking an independent and highly motivated scientist to join the Chemical Biology group at the Scientist I/II level. Our group is responsible for identifying novel drug targets from phenotypic screens using cutting edge chemical biology and functional genomic techniques. The primary responsibilities for this position include the application of pooled CRISPR approaches to small molecule target identification in neurodegenerative diseases.

The Neuroimmunology Research at Biogen is seeking a highly motivated scientist with a demonstrated track record of publications and presentations to drive independent basic exploratory research programs and lead cross-functional drug development team. The successful research scientist should possess a strong understanding of the mechanistic basis of neuroinflammation/neurodegeneration, as well as cutting edge knowledge on microglia and astrocyte biology, including familiarity with in vitro and in vivo models of neuroinflammation and neurodegenerative diseases. The scientist will be expected to apply a deep and broad knowledge of experimental neuroinflammation to creatively explore new biology and develop novel therapeutics. While prior drug development experience is preferred but not required, the candidate must have demonstrated the ability to work closely with research scientists in a team environment. Flawless oral and written communication skills are essential.

We seek a talented and highly collaborative computational biologist that has extensive experience with 1) RNA Sequencing for transcriptome analysis, and 2) applying short and long read DNA-Seq methods for mutation mapping and viral genome characterization, and a keen interest in applying these methods to the discovery and development of novel therapeutics for the treatment of neurodegenerative diseases.

Verge Genomics is seeking a Scientist or Senior Scientist to join the Neurobiology Research and Drug Discovery team. This candidate will bring significant academic and preferably pharmaceutical industry experience to conduct in vivo and in vitro research in our SF Bay Area laboratories and join team meetings at Verge Genomics headquarters in SF. The candidate will be responsible for the design and execution of target validation and evaluation of novel drug candidates for neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) and Parkinson’s disease. The candidate will conduct in vivo studies in mice, including injections of gene modifying agents and drug candidates to neonatal and adult rodents using intracranial, oral, or intravenous administration routes. Experience with stereotaxic surgery, gene therapy (AAV9 or ASO), behavioral observations, gait analysis, rotarod and grip strength, and genotyping are a plus. The candidate will have extensive knowledge of CNS disease mechanisms, existing therapies, and experimental therapeutic approaches. The candidate will also culture motor neurons differentiated from induced pluripotent human stem cells and design and develop cellular assays to identify genes and compounds for treating neurodegenerative diseases including ALS and PD. The candidate will have extensive experience and leadership skills with sterile in vitro methods, including harvesting, storing, growing, and expanding neuronal cultures, formulating and adding compounds and molecular probes, measuring cells numbers and properties with immunohistochemical markers, and evaluating gene transfection. A keen ability to identify efficient solutions to laboratory problems and expertise with statistical analysis are essential. This position reports to the Director of Drug Discovery.

Prevail Therapeutics, Inc is a new biotech company based in New York City. Prevail is developing novel treatments for neurodegenerative disorders using gene and protein therapeutic modalities. Prevail is backed by a top-tier healthcare focused investment firm.

Teva Pharmaceuticals has an opening for a Scientist 1 in vivo biologist. The individual should have substantial experience with the use and development of in vivo rat and/or mouse models for CNS disorders including neurodegeneration, including rodent behavior, surgical approaches, and genetic and/or viral vector modeling approaches. Knowledge of pharmacology and pharmacokinetics as they relate to CNS drug discovery is preferred.

This lab-based chemist will be a key part of an interdisciplinary team of scientists and will be involved in the design, synthesis, purification, and characterization of novel drugs in the areas of neurodegenerative disease. In this dynamic team focused role, the qualified candidate will also be expected to manage and run the chemistry laboratory, and act as a mentor for junior chemists as needed.

Sanofi’s Neuroscience Research Therapeutic Area based in Framingham, MA is looking for a highly qualified and motivated Scientist to develop therapies for rare neurologic and neurodegenerative diseases. This laboratory based position will include the opportunity to lead project teams and interact with internal and external functions to initiate new drug discovery programs and advance ongoing projects. The candidate will use epigenetics tools, genome editing technologies, –omics, bioinformatics and other approaches to identify and validate new targets. The candidate will also advance understanding of the role of the non-coding genome to identify and validate innovative and transformative therapies for rare neurologic diseases.

Genentech is inviting applications for a Scientist position (rank equivalent to assistant professor in academia) in the Department of Neuroscience. We are seeking an exceptional, highly motivated and creative scientist to lead innovative research efforts focused on unraveling the mechanisms of neurodevelopment and/or brain function in the context of nervous system diseases. He/she will also be expected to participate in inter-disciplinary teams to identify novel drug targets and discover new drugs to treat nervous system disorders. The ideal candidate will have significant experience in molecular and cellular biology using both in vitro and in vivo model systems, and possess a deep mechanistic understanding of the cellular pathways that contribute to diseases of the nervous system (e.g. neurodegenerative diseases). A solid track record of publications in top tier journals is required as is exceptional communication skills. The position will involve close collaboration with other research labs in Neuroscience as well as investigators in areas such as human genetics, bioinformatics, proteomics, imaging, and small molecule and large molecule drug discovery. The successful candidate will be expected to publish their research in high quality journals.

We are seeking a Research Senior Associate Scientist to join a vibrant and growing group currently focusing on Neurodegenerative diseases within the Neuroscience Therapeutic Area, a key component of the Discovery Research unit at Amgen’s site in Cambridge, MA (Amgen MAssachusetts-AMA). The successful candidate must be highly motivated with a deep interest in developing new and effective therapeutics for Parkinson’s disease (PD)/ALS.

We are seeking a Research Senior Associate Scientist to join a vibrant and growing group currently focusing on Neurodegenerative diseases within the Neuroscience Therapeutic Area, a key component of the Discovery Research unit at Amgen’s site in Cambridge, MA (Amgen MAssachusetts-AMA). The successful candidate must be highly motivated with a deep interest in developing new and effective therapeutics for Parkinson’s disease (PD)/ALS.

The Neuroimmunology department at Biogen is searching for a committed, enthusiastic and dependable associate scientist to assist with the design, execution and interpretation of preclinical studies for drug discovery and development. The incumbent will be part of a multifunctional team with responsibility for target validation and evaluation of novel drug candidates for neurodegenerative/neuroinflammatory diseases. He/she should be able to plan and execute in vivo and in vitro experiments with high level of independency, organization and scientific rigor. He/she should be able to maintain an up-to-date knowledge of pertinent literature and possess excellent communication and interpersonal skills to efficiently present results to project team members.

We are currently seeking a Senior Clinical Trials Manager to join our Clinical Operations group to provide key clinical support for the management, operation, and execution of multiple clinical trials (including global international trials) for Cytokinetics clinical programs.

The Neuroscience Translational Medicine group at Roche is recruiting a Translational Medicine Leader to lead early development projects, chiefly in the areas of neurodegenerative and neuro-immunologic disorders. The position reports directly to the Section Head of Translational Medicine Neuroscience/Neurology. In this role you will lead early stage clinical projects through proof of mechanism and proof of concept to transform molecules into new medicines in area with high unmet medical need.

The Pharmacometrician is responsible for the construction, validation, and implementation of disease, placebo, exposure-response, and mechanistic PKPD models to evaluate risk/benefit and facilitate drug development decisions, in close collaboration with Clinical Pharmacologists and other R and D partners.

Cytokinetics is a late-stage biopharmaceutical company focused on discovering, developing and commercializing first-in-class muscle activators as potential treatments for debilitating diseases in which muscle performance is compromised and/or deteriorating. With an unmatched understanding of muscle biology and mechanics of muscle performance, the company is developing small molecule drug candidates specifically engineered to increase muscle function and contractility. Working collaboratively, Cytokinetics’ dedicated employees are focused on advancing novel mechanism therapeutics to dramatically improve the lives of patients. With purpose and passion, we have committed to make an important impact on serious medical illnesses.

Verge Genomics is seeking a Research Associate or Sr. Research Associate to join the Neurobiology Research and Drug Discovery team and contribute to innovative research in finding therapies to treat CNS diseases. This candidate will bring pharmaceutical industry experience to conduct in vivo and in vitro research in our SF Bay Area laboratories and join team meetings at Verge Genomics headquarters in SF. The qualified candidate will be highly motivated, interactive and creative with ability to work across functions and projects. The candidate is responsible for contributing to the execution of target validation and evaluation of novel drug candidates for neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) and Parkinson’s disease. The ideal candidate will have working knowledge of CNS disease and or mechanisms with existing and experimental therapeutic approaches. A keen ability to identify efficient solutions to laboratory problems and working knowledge with statistical analysis are essential. This position reports to the Director of Drug Discovery.

Voyager is seeking a highly motivated biologist to contribute to our research team at our facility in Cambridge, Massachusetts. This is an ideal position for an individual with a strong background in in vitro and in vivoexperimental methods, who thrives in a team-oriented, fast-paced, and cross-disciplinary start-up biotech environment. The individual will work in the laboratory and be responsible for experimental execution, and data analysis for research studies supporting cutting edge therapeutic programs and platform discovery research in neurodegenerative disease areas. We are looking for extensive prior hands-on in with techniques such as cell culture, in vitro assay development and execution, CNS tissue preparation, qRT-PCR, western, and ELISA.

The Gene Therapy Program (GTP) and Orphan Disease Center (ODC) are entering a new era of unprecedented opportunity with great potential to reshape the face of medicine as we know it. Our discoveries have set the stage for successful treatments and possibly even cures for devastating genetic diseases. Our R&D organization has a translational infrastructure that includes: technology discovery, specialized immunology assays operating under GLP, a Vector Core/Manufacturing unit that conducts GMP comparable work, and a large non-clinical program for animal testing under GLP including large NHP and rodent vivaria.

The IGM is seeking a Senior Research Project Manager interested in joining a group of Investigators using cutting edge genomic technology to study genetics with a primary focus on identifying and biologically characterizing genetic variation underlying human disease.

Applications are invited for a senior research officer post to join a cross-disciplinary drug discovery group focussed on developing new therapies for neurodegenerative disorders. Located within the School of Medicine, University of Edinburgh, the successful candidate will play a key role in a cross-institute drug discovery initiative which represents a collaboration between the Centre for Clinical Brain Sciences, the Centre for Discovery Brain Sciences and the Institute of Genetics and Molecular Medicine. They will work in a dynamic multi-disciplinary environment using state-of-the-art cell biology and imaging techniques to advance phenotypic screening and drug discovery in neurodegenerative disease.

AveXis is seeking an experienced Sr. Lab Scientist to join the dynamic and growing analytical team to help establish analytical methods for process characterization and lot release of the clinical or commercial materials. The individual will collaborate closely with the internal R&D team to develop and optimize meaningful, next-generation cell-based potency and other functional assays in support of development and commercialization of new gene therapy medicines. The individual will be responsible for assay optimization and troubleshooting as well as for ensuring consistency of assay performance and cell culture work. The individual will play an important role in method qualification/validation and method transfer to internal and/or external QC laboratories. Responsibilities will also include execution of routine assays and supporting lab operation. Successful candidate will have extensive experiences in tissue culture work and will be a fast-learner with passion for innovative technology and science.

Evotec’s headquarters in Hamburg (Germany) is seeking a highly motivated and creative Senior Scientist (f/m) Biomarker in Neurodegeneration Research full-time and permanent to join our Neurobiology Department and help drive projects in the research area of Huntington’s Disease and other neurodegenerative disorders.

Sage Bionetworks is recruiting a scientist with bioinformatics or computational biology experience to lead integrative genomic analysis within multiple consortia of biologists and computational biologists studying neurodegenerative and neuropsychiatric diseases.

Voyager Therapeutics is developing recombinant adeno-associated virus (rAAV) vectors for treating neurological diseases. Developing robust and reliable vector production processes is central for establishing successful gene therapy applications. Voyager is seeking a highly motivated Senior Scientist and/or Engineer to join the Process Development Group with a focus on upstream production. The qualified candidate will be a leader within the group with a strong background and expertise in cell culture manufacturing of biologics. Primary responsibilities will include carrying out upstream process development activities for the manufacture of pre-clinical and cGMP grade rAAV products, participating in and leading internal productions, writing appropriate documents and carrying out technology transfer to assorted CMOs, and finally participating in cGMP manufacture person in plant activities. The ability to independently organize and design experiments, analyze data and report the results of their and other’s work in a concise and well documented manner, and to take the initiative to successfully drive Voyager’s projects and manufacturing process are all important aspects of the position.

We seek a highly motivated, productive, and creative Senior Scientific Researcher to join our endeavor in basic neuroscience research and pursuit of innovative treatments for CNS diseases. The individual will use a variety of neurophysiological and molecular/cellular techniques to investigate basic mechanisms of neurological disease and identify new therapeutic targets. Areas of interest include understanding the roles of neural circuit dysfunction and neuroinflammation in neurodegenerative conditions. He/she will be expected to independently design, execute and analyze experiments, as well as frequently interact and communicate with other groups as part of a diverse and multidisciplinary team. This is a hands-on laboratory position with abundant opportunity for collaboration with other researchers in a highly dynamic and fast-paced environment.

Yumanity is seeking a creative, experienced, talented and versatile scientist to join our interdisciplinary team and advance novel drug discovery programs. The position will be laboratory based, and requires strong experimental skills in neurobiology, preferably with experience in assay development. The position reports to the director of discovery biology and will collaborate across all of Yumanity’s core discovery platforms, including chemistry, yeast screening and target identification.

Yumanity is seeking a creative, talented and versatile Ph.D scientist to join our interdisciplinary team to help advance our novel drug discovery programs. This position will be laboratory based, and requires strong experimental skills in neurobiology and assay development. The scientist in this position will collaborate across all Yumanity’s core platforms, including yeast phenotypic screening, target identification and chemistry.

Sanofi’s Neuroscience Research Therapeutic Area based in Framingham, MA is looking for a highly motivated Sr. Scientist to help identify innovative therapies for amyotrophic lateral sclerosis (ALS). The successful candidate will implement manifold in vitro experimental approaches to investigate the underlying disease biology of ALS and to validate novel therapeutic targets for the treatment of ALS. These techniques include cell culture, molecular biology, biochemistry, immunoblotting, immunohistochemistry, and microscopy. The successful candidate will also use transgenic mouse models to support the in vivo investigation of potential therapeutic approaches.

Voyager is seeking a highly motivated scientist to contribute to the Analytical Development group. The qualified candidate will participate in development, qualification, and transfer of new state-of-the-art analytical methods to be used for characterization and release of Voyager’s products. This role is currently an individual contributor but may expand to having direct reports in the future. This position is located in Cambridge, MA. Primary responsibilities include, but are not limited to, the following:

The Merck Early Discovery Neuroscience team is seeking a highly motivated and technically skilled neuroscientist with a strong background in neuroimmunology to join our Boston-based early drug discovery team. Position is for a lab-based biologist who will generally be responsible for supporting the identification and validation of novel targets. The primary responsibilies will include the design and execution of both in vitro experiments and in vivo studies – applying biochemical, cellular/molecular, histological and imaging techniques – to drive toward a deeper understanding of disease pathogenesis, establish novel models thereof, and enable mechanism of action assessments for candidate therapeutics. The Senior Scientist will be an active participant in the critical scientific dialogue that supports our mission of early discovery in support of the Merck Neuroscience pipeline.

We are currently seeking an experienced and highly motivated Neuroscientist who shares our passion for the promise of RNAi therapeutics to join us at the Scientist/Senior Scientist level. The successful candidate will work with our multidisciplinary CNS team to advance our CNS platform. They will have a strong background in neuroscience with a focus on cell biology as well as biomarker discovery and development.

An opportunity exists for a leading candidate with a strong scientific background in neuroscience and a track record of success in drug discovery to contribute to Astex’s expanding drug discovery portfolio in CNS and oncology. The successful candidate will be highly-motivated with demonstrated technical ability and the capacity to think independently and creatively. They should be an excellent communicator, able to interact with both internal multi-disciplinary project teams and external experts in the field. This is an exciting opportunity to contribute your in-depth knowledge of neuroscience to drug discovery and to drive future success and innovation in neurodegeneration projects at Astex.

As a Senior Scientist in Merck’s Neuroscience Department you will engage in exciting drug discovery research targeting the treatment of Neurodegenerative diseases. An expert in cellular and molecular biology, you will have the opportunity to work as part of a high profile team applying cutting edge cell biology techniques to identify, validate and progress innovative novel drug targets. You will design, implement and run biochemical and cell based assays to support our drug discovery efforts.

The Merck Early Discovery Neuroscience team is seeking a passionate, research focused and technically skilled in-vitro scientist with strong molecular, cellular and biochemistry expertise in neurodegenerative diseases to join our Boston-based research community. The high-level goal of the group is to effectively advance de novo discoveries from within the laboratory toward medicines to treat neurodegenerative diseases. The concentration of the group is centered on understanding the key determinants of microglia that impact their functional responses to neurodegenerative disease states. Mainly, how do genetic mutations in selected neuroimmune genes confer neurodegenerative susceptibility and by what common or unique mechanisms? By generating and characterizing transgenic models and developing cell-based systems, the team aims to gain insights into causal disease pathophysiology informed by human genetics using combinations of molecular and functional profiling technologies. Target, pathway and functional insights are pressure-tested with pharmacological, biologic and genetic experimental tools to validate insights and mechanistic hypotheses. A core part of the group mission and responsibility of the Senior Scientist is to establish, optimize and transfer insights and assays to enable target and pathway screening. To that goal, candidates with extensive expertise in cellular and molecular neuroscience with de novo assay development experience are encouraged to apply.

The Neuroscience Exploratory Biology Lead at Celgene will have the responsibility for testing novel concepts in cell based drug discovery and target validation for neurodegenerative diseases. The two foundational activities of this group will be to evaluate and implement new cell based screening approaches and, secondly, to develop and support internal collaborations that exploit Celgene expertise in target and lead discovery. The position will have an outward facing role as well, utilizing and leading collaborations with contract research organizations, academic labs, and other drug discovery companies to fulfill the mission of developing new therapeutics for neurodegenerative diseases. The candidate should have demonstrated expertise in applying a variety of genetic and compound based screening approaches in a relevant field of biology. The candidate should be equally adept contributing to our science directly and through leading and guiding others.

Verge Genomics is seeking a highly motivated individual to spearhead pre-clinical development of disease modifying treatments for neurodegenerative diseases. You will be responsible for advancing our current and emerging lead candidate pipeline through all stages of pre-clinical development, acting as a leader of multidisciplinary project teams. You will oversee important external collaborations with contract research organizations (CROs), leading academic groups, non-profits, and pharmaceutical partners. As one of the first employees at Verge, you will develop help build the foundation of a revolutionary drug development model.

An exciting opportunity for a motivated Senior Technician to join our new Project ALS Preclinical Core Facility at Columbia University Medical Center. The facility tests new treatment strategies and research drugs in mouse models of amyotrophic lateral sclerosis.

An exciting opportunity for a motivated Senior Technician to join our new Project ALS Preclinical Core Facility at Columbia University Medical Center. The facility tests new treatment strategies and research drugs in mouse models of amyotrophic lateral sclerosis.

The Neurodegeneration and Repair Research Unit is seeking a motivated and experienced scientist to join a group a cutting edge research group focused on the rapid progression of novel therapeutics for neurodegeneration. The successful candidate will join a highly productive team that has established robust in vivo and in vitro assays, in support of project and company drug discovery and development goals.

The Sr. Clinical Scientist will work with the Medical Director functions of Early Clinical Development teams and provide scientific and clinical input into early stage clinical development programs. This role will work on cross-functional study teams for the design, execution, and monitoring of clinical trials, early clinical research studies, and/or external research projects, as well as assist with data interpretation and communication.. This individual will report directly into a Sr. Medical Director of Clinical Development or a Therapeutic Area VP and will interface directly with other functions including Clinical Development, Clinical Pharmacology, and Biomarkers.

Cytokinetics is a late-stage biopharmaceutical company focused on discovering, developing and commercializing first-in-class muscle activators as potential treatments for debilitating diseases in which muscle performance is compromised and/or deteriorating. We seek a highly motivated and experienced Senior Research Associate/ Scientist I to join our Discovery Biology group. This individual will play a key role in designing, optimizing, and implementing a wide-range of biochemical and cell-based assays, as well as in assessing biochemical and cellular activity of candidate compounds. As a member of a multidisciplinary team, you will work closely with team members to identify, characterize and advance compounds through research and preclinical development.

The Neuroscience Exploratory Biology Lead will have the responsibility for testing novel concepts in cell based drug discovery and target validation for neurodegenerative diseases. The two foundational activities of this group will be to evaluate and implement new cell based screening approaches and, secondly, to develop and support internal collaborations that exploit Celgene expertise in target and lead discovery. The position will have an outward facing role as well, utilizing and leading collaborations with contract research organizations, academic labs, and other drug discovery companies to fulfill the mission of developing new therapeutics for neurodegenerative diseases. The candidate should have demonstrated expertise in applying a variety of genetic and compound based screening approaches in a relevant field of biology. The candidate should be equally adept contributing to our science directly and through leading and guiding others.

Columbia University’s Department of Pathology and Cell Biology has an immediate opening for a Staff Associate/Sr. Staff Associate position in Dr. Livio Pellizzoni’s lab.The incumbent will be responsible for carrying out fully planned experiments, in liaison with Postdoctoral Research Scientists/Fellows as well as PhD students, to study the molecular and cellular mechanisms of neurodegenerative disease in mouse models. The incumbent will use conventional biochemical, cellular, molecular, immuonohistochemical and behavioral assays. He/She will also maintain the mouse colonies, daily behavioral monitoring of mice, genotyping, ICV/IP injections, tissue dissection and immunohistochemistry. The incumbent will also be responsible for confocal microscopy, image analysis, statistical evaluation of results, as well as preparing solutions and performing other laboratory related duties necessary to the functioning of the research projects.

This lab-based chemist will be a key part of an interdisciplinary team of scientists and will be involved in the design, synthesis, purification, and characterization of novel drugs in the areas of neurodegenerative disease. In this dynamic team focused role, the qualified candidate will also be expected to manage and run the chemistry laboratory, and act as a mentor for junior chemists as needed.

The Neuromuscular Program in the Department of Neurology at the University of Miami has an exciting opportunity for a full-time or part-time Statistical Programmer to join an active clinical and translational research group focused on therapy development for Lou Gehrig’s disease (Amyotrophic Lateral Sclerosis, or ALS). The statistical programmer will be an integral member of the research team and provide programming support for the cleaning, summarizing/reporting, and analysis of research data. The statistical programmer will work most closely with the biostatistician and the data manager. The appropriate title for the position will be contingent upon the selected candidate’s education and years of experience. Candidates with additional experience could be considered for a Sr. Statistical Programmer position.

The Neuromuscular Program in the Department of Neurology at the University of Miami has an exciting opportunity for a full-time or part-time Statistical Programmer to join an active clinical and translational research group focused on therapy development for Lou Gehrig’s disease (Amyotrophic Lateral Sclerosis, or ALS). The statistical programmer will be an integral member of the research team and provide programming support for the cleaning, summarizing/reporting, and analysis of research data. The statistical programmer will work most closely with the biostatistician and the data manager. The appropriate title for the position will be contingent upon the selected candidate’s education and years of experience. Candidates with additional experience could be considered for a Sr. Statistical Programmer position. The primary responsibilities are: Develop and implement strategies for real-time data QC. Conduct routine data checks to ensure data integrity. Write SAS macros and programs for data cleaning, reporting (e.g. tables, listings, figures), and the creation of analysis datasets. Construct view tables from a MySQL database. Perform statistical analyses defined in statistical analysis plans, as needed. Perform other related duties and responsibilities, as assigned.

The Maniatis lab is seeking a highly motivated Technician B to work on a project focusing on the progression of the neurodegenerative disease Amyotrophic Lateral Sclerosis (ALS). The technician will work closely with colleagues using techniques such as in vivo mouse genetics, gene expression profiling and in vitro cell culture assays. Comfortability with dissections preferred.

We sincerely invite applications from outstanding translational scientists who aim to conduct cutting-edge and innovative research. Successful applicants will be offered generous start-up packages and internationally competitive benefits. Positions will remain open until filled.

The National Institutes of Health, the U.S. government’s premier biomedical and behavioral research enterprise and a component of the Department of Health and Human Services, is pleased to announce its tenth annual call for researchers who want to be “NIH Earl Stadtman Investigators”. These are tenure-track positions (assistant professor equivalent) within the NIH Intramural Research Program (IRP).