Cairo Genizah: Thirty-five thousand fragments containing invaluable information pertaining to the social, cultural, religious and economic life of Mediterranean Jewry from the ninth through the nineteenth centuries. All the fragments have been digitized and are available online through The Friedberg Genizah Project.

History: More than 400 pinkassim (record books) from Jewish communities and organizations throughout Europe, Africa, Asia, and North America, dating from the sixteenth to the twentieth centuries.

History of Science and Medicine: Two hundred fifty manuscripts dealing with the topics of medicine, math, astronomy, and astrology.

Kabbalah and Mysticism: Seven hundred manuscripts of both "practical" and "theoretical" Kabbalah.