The National Republican Senatorial Committee took aim at Mary Landrieu (D-La.) Wednesday morning with its first ad of the 2014 election cycle, saying she has been misfiring on healthcare, energy, taxes and jobs.

According to NRSC's website, the ad, "Misfire," will first air during season premiere of Duck Dynasty Wednesday night, and will run over the next two weeks on cable.

Landrieu -- at the Baton Rouge Rotary Club Wednesday to give an overview speech on Louisiana's coastal issues, education and economic connectivity around the state -- was reluctant to comment on the ad, saying it was small.

"Clearly from the speech I gave today, clearly from the record that I have, I am in-sync with Louisiana voters and Louisiana vision on many issues from coastal, education, economic development and military expansion," Landrieu said.

The senator did not discuss health care reform during her formal remarks, saying Rotary Club-imposed time limits made it impossible to properly address the subject. She did, however, speak briefly on the issue with reporters afterwards.

"The Affordable Care Act is going to be better than the old system, which was that less and less people had insurance. Less and less people could buy insurance," Landrieu said.

"There were less and less companies offering insurance. People couldn't get insurance because they had cancer or pre-existing conditions, pregnancy was deemed a pre-existing condition, I can promise you, (when) we fully get to implement it, all of those things will be reversed."

Landrieu's campaign was quick to respond Wednesday evening.

"This ad is a total quack. It is a desperate, misleading attempt by the NRSC, which hopes it will help them duck the fact that Mary Landrieu has spent her entire time in the Senate fighting and winning for Louisiana," Adam Sullivan, Sen. Landrieu's campaign director said in an email.

"It was her bill, GOMESA, that opened up 8.3 million acres in the Gulf for domestic drilling, established evenue sharing for Louisiana to restore its coast and created good-paying energy jobs. And, unlike others in this race, Sen. Landrieu voted last January to provide permanent tax relief to Louisiana's middle class families."