DiMeth 40% question

I remember someone telling me that I can use the Dimethoxy 40% solution orally for my kids to prevent coccidiosis. I live on the rainy north coast of California where cocci is endemic (80 degrees here today-absolute heat wave for us!). Does anyone out there use it and what is the oral dosage? I have two fullblood boer bucklings that are 3 weeks old today and I hoped to start using it...I bought the bottle but that's as far as I've gotten.

joan you can start di-methox today with your kids weight them and than give 1cc per ten pound today, following four days you give 1/2 cc per ten pound.
mark your calendar and start treatment in 20 days. i would also worm with valbazen same dosage 1 cc per ten pound but only once.

yes the treatment is for five consecutive days, starting over again, and again every 20-21 days till they are around 7-8 months it is .08 - 1% of weight the first day, and days 2-5 .04 % - .05% it's easier to do the math for the 1 % and .05 % for instance if your kid weighs 20 lb. then day one 2cc's of dimethox, (and 2 cc's of valbazen wormer) day 2 1 cc of dimethox and no wormer, day 3 1 cc of dimethox repeat day 4 & 5

for 30 lbs day on 3 cc's and the wormer ; ) day 2 -5 1.5 cc's dimethox

Yes, but many goat breeders in Indiana, Mich, Ohio, and Texas use this dosage, Its a much more wildly accepted dosage. Hoeggers are a supply cataloge, doesn't mean they know the dose's I disagree with a lot of their info, such as the herbal wormers, and the dimethox dose.

She is not in a cold area like we are, I'm sure they don't have the winter kill like we do. They have much larger parasite burdens for much of the year. While our pens are frozen solid with no living worms and such.

However I run my goats as a business, I expect them to thrive, milk reproduce, and grow well. You all run your own goats as you wish.

i'm not sure if we can say that hoeggers has the dosage wrong. i did that too but this does not make it right.
first of di-methoxx is not labeld for goats. how do we know we are using the right dosage?
i think the best advice would be to make a fecal check after treatment since coccidosis shows not always diarhea.

this is the fact sheet for this drug. it definitive uses body weight for calculating the dosage.

Sulfadimethoxine is a white, almost tasteless and odorless compound. Chemically, it is N1-(2,6-dimethoxy-4-pyrimidinyl) sulfanilamide. The structural formula is:

ACTIONS: Sulfadimethoxine has been demonstrated clinically or in the laboratory to be effective against a variety of organisms, such as streptococci, klebsiella, proteus, shigella, staphylococci, escherichia, and salmonella.1,2

The systemic sulfonamides which include sulfadimethoxine are bacteriostatic agents. Sulfonamides competitively inhibit bacterial synthesis of folic acid (pteroylglutamic acid) from para-aminobenzoic acid. Mammalian cells are capable of utilizing folic acid in the presence of sulfonamides.

The tissue distribution of sulfadimethoxine, as with all sulfonamides, is a function of plasma levels, degree of plasma protein binding, and subsequent passive distribution in the tissues of the lipid-soluble un-ionized form. The relative amounts are determined by both its pKa and by the pH of each tissue. Therefore, levels tend to be higher in less acid tissue and body fluids or those diseased tissues having high concentrations of leucocytes.2

To assure successful sulfonamide therapy (1) the drug must be given early in the course of the disease, and it must produce a high sulfonamide level in the body rapidly after administration, (2) therapeutically effective sulfonamide levels must be maintained in the body throughout the treatment period, (3) treatment should continue for a short period of time after the clinical signs have disappeared, and (4) the causative organisms must be sensitive to this class of drugs.

TOXICITY AND SAFETY: Data regarding acute (LD50) and chronic toxicities of sulfadimethoxine indicate the drug is safe. The LD50 in mice is greater than 2 g/kg body weight when administered intraperitoneally and greater than 16 g/kg when administered orally. In dogs receiving massive single oral doses of 3.2 g/kg body weight, diarrhea was the only adverse effect observed. Dogs given 160 mg/kg body weight orally daily for 13 weeks showed no signs of toxicity.

In cattle sulfadimethoxine has been shown to be safe through extensive clinical use with other dosage forms. In addition, studies with intravenous administration of Sulfadimethoxine Injection 40% have demonstrated that hemolysis of erythrocytes does not occur by this route of administration. Sulfadimethoxine has a relatively high solubility at the pH normally occurring in the kidney, precluding the possibility of precipitation and crystalluria.

LIMITATIONS: Sulfadimethoxine is not effective in viral or rickettsial infections, and as with any anti-bacterial agent, occasional failures in therapy may occur due to resistant microorganisms. The usual precautions in sulfonamide therapy should be observed.

WARNING: Milk taken from animals during treatment and for 60 hours (5 milkings) after the latest treatment must not be used for food. Do not administer within 5 days of slaughter.

A withdrawal period has not been established for this product in preruminating calves.

Do Not Use in Calves to be Processed for Veal.

PRECAUTIONS: During treatment period, make certain that animals maintain adequate water intake.

If animals show no improvement within 2 or 3 days, consult your veterinarian.

Tissue damage may result from perivascular infiltration.

DOSAGE AND ADMINISTRATION: DI-METHOX (Sulfadimethoxine Injection 40%) must be administered only by the intravenous route in cattle. Cattle should receive 1 mL of DI-METHOX (Sulfadimethoxine Injection 40%) per 16 pounds of body weight (55 mg/kg) as an initial dose, followed by 0.5 mL per 16 pounds of body weight (27.5 mg/kg) every 24 hours thereafter. Sulfadimethoxine Boluses may be utilized for maintenance therapy in cattle. Representative weights and doses are indicated in the following table:

Each mL contains 400 mg sulfadimethoxine:

Animal Weight

Initial Dose

25 mg/lb (55 mg/kg)

Subsequent Daily Doses

12.5 mg/lb (27.5 mg/kg)

Length of treatment depends on the clinical response. In most cases treatment for 3 to 5 days is adequate. Treatment should be continued until the animal is asymptomatic for 48 hours.

NOTE: Store at room temperature. Should crystallization occur at cold temperatures, crystals will dissolve either by storing at room temperature for several days or by heating the vial in warm water. Crystallization and redissolution do not impair the efficacy of the product.

Thanks for the discourse! Yes, we are wet and soggy from Nov through Juneish. I am going to try them at the higher dose simply because my vet says that cocci is such an incredible problem here and I believe him! I

However I run my goats as a business, I expect them to thrive, milk reproduce, and grow well. You all run your own goats as you wish.

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That really was not called for. I also raise mine to milk, grow well, reproduce, & thrive. It was not necessary to make such a remark. Apparently you are one of the people that thinks your way is right & everyone else is wrong. One reason I don't post on this board much. I posted what I do & was under the impression that the dosage I use is the preventive dose. I have many fellow goat keepers that use the same dose. I did not mean to imply that my way was the only right way. Just stating how I do it. Do not assume that my goals are not the same as yours just because I do not do things the same. I have had goats almost 20 years.

the most important thing is to have a careful look at our goats and act accordingly. we can't have all the same management because our goats life in different conditions, have differnd diets, different clima . because my neighbor doesn't treat the goats the same as i do does not make his management bad.
wendy if you are having good results in what you are doing i don't see any problems. i'm sure you have nice goats

There are also a lot of people around who don't even treat for cocidiosis at all, in our cold area and haven't had problems with it "yet" but you know how it is with goats it always seems to be your Favorite goats that get sick.