Cardiovascular Gene Annotation

February Cardiovascular Newsletter

20-21 April Bioinformatics & Gene Ontology Workshop

We organise an annual bioinformatics workshop to provide information about GO and other bioinformatic resources to research scientists throughout UCL and to encourage their participation in the process of gene annotation.

This collaboration builds on our previous 5 year annotation initiative which led to the associated over 16,000 GO terms to 1919 human proteins, for an example, see the annotation record of the fully annotated APOA4 protein. In addition. during these 5 years we contributed to the creation of over 1100 GO terms; over 500 of these terms were developed following ontology discussions with experts in heart development and cardiac conduction.

These new BHF-funded GO terms facilitated the detailed and high-quality annotation of cardiovascular-relevant genes. The impact of which is demonstrated in Alam-Faruque, 2011.

In the current project we will be dividing our time equally between the GO annotation of microRNAs, proteins and the capture of protein-protein
interactions.
Annotations
contributed by this project to the GO consortium dataset and the IMeX dataset are attributed to BHF-UCL.

We have prioritised 4,000 cardiovascular-associated proteins for annotation:

However, we are still looking at which microRNAs to include in our cardiovascular priority list.

We welcome feedback from cardiovascular scientists and encourage researchers to review the annotation of their 'favourite' gene and suggest information that may be missing, inaccurate or incomplete in these annotations.

Comments and suggestions of papers or genes to be annotated can be sent via

The work of the Cardiovascular Gene Annotation group is supported by British Heart Foundation grant RG/13/5/30112. The work of the Neurological Gene Annotation group is supported by Parkinson's UK grant G-1307.