..We conclude that the actions of activin, inhibin, and follistatin are consistent with LH/FSH secretion patterns, and likely complement other factors in the production of the characteristic secretion patterns in female rats...

..Finally, we use the model to address the recent finding that the activity of islets from some mice is uniformly fast, whereas that from islets of other mice is slow. We propose a mechanism for this dichotomy...

..The initial effect is stimulatory, followed later by inhibition that persists long after the agonist has been removed. Recent research has uncovered several G protein pathways that mediate these effects...

Filtering of calcium transients by the endoplasmic reticulum in pancreatic beta-cells

..The initial effect is stimulatory, followed later by inhibition that persists long after the agonist has been removed. Recent research has uncovered several G protein pathways that mediate these effects...

A minimal model for G protein-mediated synaptic facilitation and depression

..In fact, OT injection failed to induce a PRL secretory rhythm in pelvic-neurectomized animals, suggesting that the integrity of the pelvic nerve is necessary for the systemic OT induction of the PRL secretory rhythm in OVX rats...

A mathematical model for the mating-induced prolactin rhythm of female rats

..Finally, we consider potential targets for a rhythm-terminating factor and make predictions that may be used to determine which mechanism is operational in terminating the OT- or mating-induced PRL rhythm...

The rhythmic secretion of mating-induced prolactin secretion is controlled by prolactin acting centrally

..These results demonstrate that PRL acts centrally to induce the PRL rhythm and that PRL in the brain is essential for the maintenance but not for the initiation of the CS-induced rhythmic PRL surges...

Prolactin secretory rhythm of mated rats induced by a single injection of oxytocin

..Mathematical modeling was used to illustrate the proposed network function. The experimental results further suggest an additional feedback mechanism in which certain hypothalamic OTergic neurons are influenced by PRL...

Oxytocin action at the lactotroph is required for prolactin surges in cervically stimulated ovariectomized rats

..However, only the subtractive process plays a major role in setting the duration of the silent phase. This computational method can be used to analyze the role of negative feedback processes in a wide range of biological rhythms...

..This work further shows that networks with widely different architectures, different cell types, and different functions all operate according to the same general mechanism early in their development...

..We show that the combined model can reproduce several complex bursting patterns from mouse islets published in the literature, and we illustrate how these complex oscillations are produced through the use of a fast/slow analysis...

Dual pre-motor contribution to songbird syllable variation

John A ThompsonProgram in Neuroscience and Department of Psychology, Florida State University, Tallahassee, Florida 32306 4301, USAJ Neurosci 31:322-30. 2011

....

Models of electrical activity: calibration and prediction testing on the same cell

..This analysis shows that the observed phase relation between citrate and NAD(P) places strict limits on the potential mechanism for the metabolic oscillations in isolated mitochondria that were observed by MacDonald and co-workers...

Determining the contributions of divisive and subtractive feedback in the Hodgkin-Huxley model

Patrick A FletcherDepartment of Mathematics, Florida State University, Tallahasee, Florida, United States of AmericaPLoS ONE 9:e95613. 2014

..The findings have implications for experiments aimed at studying the frequency response to pulsatile inputs, as well as for understanding how pulsatile patterns drive biological responses via feedforward signaling pathways. ..

..We then apply the standard information-theoretic quantity K-L distance to measure dissimilarity in phonology across days of singing. A variant of this procedure can also be used to analyze differences in syllable syntax...

Auditory-dependent vocal recovery in adult male zebra finches is facilitated by lesion of a forebrain pathway that includes the basal ganglia

..These findings highlight common misconceptions about hydrogen bonding in proteins, and provide explanations for why the explicit hydrogen bonding terms of some popular force field sets are often best switched off...

..We conclude that Ca(2+) binding processes with slow unbinding times (tens to hundreds of milliseconds) constitute a viable mechanism of synaptic facilitation at some synapses and discuss the experimental evidence for such a mechanism...