9 things to know about toxic shock syndrome, according to Mayo Clinic It's a rare, life-threatening complication of certain types of bacterial infections. TSS is often caused by toxins produced by Staphylococcus aureus (staph) bacteria, but it can also be caused by toxins produced by group A streptococcus (strep) bacteria. The condition has been associated with superabsorbent tampons, which have long been off the market. But it can affect anyone, including postmenopausal women, as well as men and children

Sixteen-year-old Canadian student Sara Manitoski died on an overnight school field trip last year due to toxic shock syndrome, the rare but life-threatening bacterial infection that has been linked to the use of “superabsorbent tampons” in the past, the Vancouver Island’s Comox Valley Record reported this week.

According to a report from coroner Courtney Cote, the high school junior had complained about having cramps and feeling unwell. After turning in early at her shared cabin on Hornby Island, she never woke up the next morning.

Manitoski’s classmates found her unresponsive and an original examination found skin redness all over her body, consistent with TSS.

American model Lauren Wasser first developed the syndrome in 2012, when she was 24 years old. That year, she had to have her right leg amputated. And in December, Wasser told the Washington Post, she expects she’ll “inevitably” need to have her other leg amputated as well.

According to the Mayo Clinic, TSS may be rare, but it’s a potentially life-threatening complication of certain types of bacterial infections, often caused by toxins produced by Staphylococcus aureus (or staph) bacteria.

The condition is primarily associated with the use of tampons, specifically super-absorbent ones that have long been off the market, but it can affect anyone, including men, children and postmenopausal women. Those with a skin or wound infection may be at risk.

TSS from staph bacteria has a mortality rate of between 5 and 15 percent. The rate jumps to 30 to 70 percent for TSS associated with strep bacteria.

Wasser wants women and young girls to know about the dangers tampons can have. Aside from the TSS fine print buried on the bottom of a tampon box, the dangers of tampons are rarely visible to consumers.

“You’ll see an ad for Advil or Viagra and hear some monotonous voice warn you about even the smaller side effects like headaches or nausea. When you see a tampon commercial, it's all happy teenage girls running along the beach in bikinis. The dangers are beyond minimized,” she wrote for InStyle.

According to Vice News, over the past 50 years, tampon composition, especially tampons from major manufacturers like Playtex, Kotex or Tampax, has changed from natural ingredients (cotton) to synthetic ingredients (rayon, plastic).

“These synthetic fibers, along with a tampon's absorbency, can form an ideal environment for staph bacteria to flourish,” Vice reported.

As aforementioned, TSS can be triggered by a bacterial infection, typically involving staph bacteria.

Wasser, for the record, was wearing Kotex Natural Balance tampons.

According to Mayo Clinic, if you use tampons, you should read the labels and use the lowest absorbency tampon possible. It’s advised that tampons are changed at least every four to eight hours and their use should be alternated with sanitary napkins. When flow is light, Mayo Clinic suggests using minipads.

For anyone that has had TSS or a prior serious staph or strep infection, tampon use is not recommended.

The longer women wear a tampon, the higher the risk for TSS. However, the condition can still occur if you change tampons frequently.

In Wasser’s case, she changed hers three times the day she began feeling sick. After attending a friend’s birthday party later that night, where she struggled to stay up and well, Wasser returned home and all she wanted to do was fall asleep.

She woke to a cop pounding on her door during a welfare check courtesy of her concerned mother, who had been worried about Wasser’s lack of communication.

“She [had] no idea how long she was in bed, and can't remember if it was day or night,” Vice reported in 2015.

Wasser was eventually rushed to a hospital with a 107-degree fever. She suffered a massive heart attack and was ten minutes from death.

“The doctors couldn't stabilize her, and nobody had any idea what was going on until they called an infectious disease specialist, who immediately asked, ‘Does she have a tampon in?’ She did, and they sent it to the lab. It came back positive for toxic shock syndrome,” Vice reported.

Her family launched a lawsuit against the company to make a point about the synthetic materials in the tampon industry and the lack of clarity about TSS risks on labels.

Most labels tell consumers to change your tampon every four to eight hours, including overnight. But Wasser and her family argued that "overnight" can mean longer than eight hours, especially when it comes to young girls, who may sleep nine or ten hours on the weekend. “[Tampon companies] should be telling you, 'Don't sleep in it. Use a pad,'" Wasser’s lawyer, Hunter Shkolnik, told Vice.

Victims, you’re not alone.

TSS is rare and most doctors are unlikely to ever see a case during their medical careers, which made Wasser feel that much more alone.

One of Wasser’s life-changing moments, she recalled in her InStyle op-ed, was when her girlfriend introduced her to the nonprofit You ARE Loved, website dedicated to raising awareness about TSS. The site is no longer active, but Wasser said connecting to other survivors helped her realize she wasn’t alone.

“It was the first thing in so long that had made me feel like I had something to live for—to make sure other women don’t have to go through what I did and to help those who have know they’re not alone,” she wrote.

While You ARE Loved is no longer up, it may be helpful for survivors to try and connect with others. There’s a TSS support group at MDJunction.com, where people share their own stories.