Antidiabetic effects

Diabetes mellitus is a chronic metabolic disorder which can damage many systems in the body, such as blood vessels and nerves. It is one of the world's most serious health concerns, developing increasingly with the dietary patterns and age. The control of blood glucose levels is very important in hyperglycemic patients, and a-glucosidase inhibitors are a cost-effective means to preventing the progression of diabetes. Fucodiph-loroethol G (IC50 19.52 pM), dieckol (IC50 10.79 pM), 6,6'-bieckol (IC50 22.22 pM), 7-phloreckol (IC50 49.49 pM), and phlorofucofuroeckol A (IC50 19.71 pM) from E. cava have shown significant inhibition of a-glucosidase (Lee et al., 2009). Several other studies have conducted to investigate in vivo antidiabetic effects by feeding phlorotannin extracts to diabetic mouse models. Ecklonia stolonifera extracts have shown strong inhibition of a-glucosidase in noninsulin dependent diabetic mice (Iwai, 2008). Feeding with E. cava extract (Kang et al., 2010) and I. okamurae extract (Min et al., 2011) have resulted in reduction of the plasma glucose level and improve insulin resistance in type 1 mellitus rats and C57BL/-KsJ-db/db mice, respectively. Diabetes is closely related to the diet, and incorporating these brown algae as medicinal dietary supplements would be a promising prevalence strategy of diabetes.

Diabetes is a disease that affects the way your body uses food. Normally, your body converts sugars, starches and other foods into a form of sugar called glucose. Your body uses glucose for fuel. The cells receive the glucose through the bloodstream. They then use insulin a hormone made by the pancreas to absorb the glucose, convert it into energy, and either use it or store it for later use. Learn more...