BioCell Technology LLC owns intellectual property rights to BioCell Collagen® and is only available to partner companies via a License Agreement. Certain restrictions apply. Please contact us for more information.

Applications

BioCell Collagen® - For use in tablet, capsule and soft gel dosage form applications.

BioCell Collagen® FG - For use in chewable, gummy, and functional food dosage form applications.

Usage

BioCell Collagen® is used in dietary supplements for the promotion of skin, joint and connective tissue health. The safety and efficacy of BioCell Collagen® has been demonstrated in multiple human studies over the decade.

FAQs

BioCell Collagen is made from pure dietary chicken sternal cartilage that is free from hormones and antibiotics. Chicken sternal cartilage closely mirrors the composition of human cartilage rich in type II collagen, chondroitin sulfate, and hyaluronic acid. Cartilage is a clean and desirable source since it's free from blood vessels, lymphatics, and nerves that are known to carry diseases and impurities. Therefore extracting exclusively from cartilage eliminates the risk of potential contamination. We use a patented manufacturing procedure that subjects the chicken sternal cartilage through various processes, including filtration, purification, concentration, hydrolysis, and sterilization to ensure consistent quality and safety. It's also important to note that the synergy of biomolecules found in BioCell's unique matrix plays a significant role in its efficacy. Various studies, including seven human clinical trials, prove the safety, efficacy, bioavailability of BioCell Collagen®.

The majority of collagen ingredients in the market are derived from the entire carcasses of animals (e.g., cow, pig, and marine). These materials are usually more than 90% protein and labeled as Collagen Peptides, Hydrolyzed Collagen, Collagen Hydrolysate, Collagen Type I & III, or Gelatin (also a form of hydrolyzed collagen).

BioCell Collagen is a 100% pure hydrolyzed chicken sternal cartilage extract dietary ingredient. Independent laboratory analysis shows that BioCell Collagen is composed of ≥60 % Hydrolyzed Collagen Type II (calculated as Total Protein), ≥20% Chondroitin Sulfate, and ≥10% Hyaluronic Acid. The previously-mentioned analyte percentages do not mathematically add up to 100% since these naturally-occurring molecules in the chicken cartilage may naturally vary as indicated with a greater than equal to sign (≥) before each analyte.

Collagen is the most abundant protein found in joint cartilage and the dermis of the skin. It provides the structural framework of your connective tissues to keep your skin firm and resilient and your joints active and fluid. Chondroitin sulfate is a naturally occurring element of joint cartilage that gives cartilage it's incredible shock-absorbing properties. Hyaluronic acid (HA) is a molecule that helps provide hydration for your skin, lubrication for your joints, and is the gel-like substance that holds your cells together.

It's also important to note that the synergy of biomolecules found in BioCell's unique matrix plays a significant role in its efficacy. Various studies, including seven human clinical trials, prove the safety, efficacy, bioavailability of BioCell Collagen®.

BioCell Collagen® is not just an ordinary collagen ingredient. BioCell Collagen® is a clinically studied dietary ingredient composed of naturally-occurring hydrolyzed collagen type II peptides, chondroitin sulfate, hyaluronic acid. BioCell's unique matrix is not a blend of individual ingredients. The synergy of biomolecules found in BioCell's unique matrix plays a major role in its efficacy. Various studies, including seven human clinical trials, prove the safety, efficacy, bioavailability of BioCell Collagen®.
Many collagen supplements on the market lack human clinical studies, do not contain efficacious ingredient quantities, or make false claims. In contrast, BioCell Collagen is backed by clinical studies and an extensive body of research. Multiple human clinical studies have been conducted on BioCell Collagen®, demonstrating that 2 grams daily is effective for joint health, while 1 gram daily is effective for skin benefits. These studies provide solid evidence that BioCell Collagen® is a unique, healthy aging dietary supplement ingredient that promotes active joints and younger-looking skin. The outcome of these studies was presented in scientific conferences and also published in scientific journals.

Yes, BioCell Collagen has been safely and successfully used by millions of consumers since its introduction in the market in 1998. It was affirmed GRAS (Generally Recognized as Safe) by an independent experts safety panel following rigorous scientific reviews not only in safety and toxicology data, but on manufacturing processes according to food Good Manufacturing Practices (GMP). Various research studies, including seven human clinical trials, support the safety, efficacy, and bioavailability of BioCell Collagen®. BioCell Collagen is non-GMO and free of gluten, soy, shellfish, fish, egg, milk, peanuts and sugar.

1. Helps rebuild the dermal matrix with highly bioavailable building blocks
Collagen, hyaluronic acid (HA), and chondroitin sulfate are essential for the healthy structure and function of the skin dermis. As one ages, the amounts of these components decrease which leads to the disorganization or collapse of the dermal matrix. Clinical studies demonstrate that supplementing with BioCell Collagen promotes skin beauty from within. Collagen provides tensile strength of the dermal matrix in which ground substances such as hyaluronic acid are interweaved. Additionally, increasing the density of dermal fibroblasts, which are responsible for biosynthesis of structural components for the dermal network, can also contribute to youthful appearance of skin.

2. Enhances skin hydration, turgidity, and inhibition of hyaluronidase
Maintaining a proper amount of HA is critical for healthy skin structure and turgidity because HA is responsible for holding water in the skin dermis. HA and collagen decrease with age, resulting in dermal dehydration, skin-sagging, and wrinkle formation. BioCell Collagen supplies highly bioavailable HA to attenuate the effect of the loss caused by natural deterioration or photo-aging. Human subjects who took a daily dose of BioCell Collagen saw HA levels increase 60-fold in their blood during 28 days of the study period.

HA levels are maintained by the coordinated action of HA syntheses and hyaluronidases. Hyaluronidase degrades HA in response to a number of normal or pathological stimuli including aging and inflammation. BioCell Collagen has been shown to inhibit hyaluronidase. Thus, BioCell Collagen can tackle an important molecular player responsible for aging-associated dehydration while replenishing the loss of the various essential structural components of the skin dermis.
In 2011, BioCell Technology performed a ground-breaking human skin study and demonstrated that daily ingestion of BioCell Collagen for 12 weeks led to a significant reduction of facial lines and wrinkles together with enhancement of hydration and stimulation of collagen biosynthesis likely from dermal fibroblasts. It also led to an increase in hemoglobin in the facial skin tissue suggesting enhanced microcirculation of blood in the dermis. The majority of the study participants experienced improved skin texture as well as enhanced moisture and reduced scaling in their face. The study outcome was published in The Clinical Interventions in Aging (2012).
(http://www.ncbi.nlm.nih.gov/pubmed/22956862)

No, not all collagen is the same or equivalent. The collagen type, source, molecular size, composition, and manufacturing process differentiate the various dietary supplement collagen products in their indications and efficacy. BioCell Technology, the supplier of BioCell Collagen, has invested in almost two decades of clinical trials and research and development activities. BioCell Technology pioneered the applications of hydrolyzed collagen type II, chondroitin sulfate, and hyaluronic acid matrix compositions and was awarded several patents for its invention.

BioCell Collagen™ and Feed Your Skin & Joints™, variously in name and/or design, are trademarks of BioCell Technology, LLC, and are registered in the United States and other jurisdictions. (Pat.: https://www.biocellcollagen.com/patents)

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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BioCell Collagen® Research Data

Various research studies, including seven human clinical trials, support the safety, efficacy, and bioavailability of BioCell Collagen®.

Toxicology/Safety Studies

The in vitro, animal and human studies conducted on BioCell Collagen, as well as the extensive historical consumption of BioCell Collagen in dietary supplements since 1998, demonstrate a good safety profile. BioCell Collagen safety data was reviewed by an Expert Panel of toxicology scientists who determined through scientific procedures that the intended uses of BioCell Collagen as a dietary ingredient are Generally Recognized as Safe (GRAS).

Furthermore, a study was published in Food and Chemical Toxicology in 2007.

BioCell Collagen® Human Bioavailability Study

Hyaluronic Acid (HA) is in virtually all tissues of the body. In the joint, HA plays two essential roles. First, it acts as a key structural molecule to form healthy, functional cartilage. Second, HA is a major component of synovial fluid, the lubricant found in our joints that allows smooth and easy movement. In a 28-day bioavailability study in humans showed that ingestion of BioCell Collagen® (1500 mg/day) led to a 60 times increase in HA levels at steady state.*

Multiple Human Clinical Trials

BioCell Collagen® Joint Support Studies

In an 80 subject, randomized, double-blind, placebo-controlled trial for joint health, investigators tested the tolerability and efficacy of BioCell Collagen® supplementation. The participants were divided into two groups and administered either 2 g of BioCell Collagen or placebo for 70 days. Compared to placebo, the BioCell group had a significant reduction of joint discomfort on days 35 (p = 0.017) and 70 (p < 0.001). Furthermore, the BioCell group experienced a significant improvement in physical activities compared to the placebo group on days 35 (p = 0.007) and 70 (p < 0.001). BioCell Collagen was well tolerated and found to be effective, thereby improving mobility and quality of life. The peer-reviewed study was published in the Journal of Agriculture and Food Chemistry. (Schauss et al., 2012).

These results were similar to the results of another earlier double-blind placebo-controlled trial tested on sixteen people. (Kalman et al., 2004).*

BioCell Collagen® Skin Beauty-from-Within Studies

1. In a 12-week study, women who took 1000 mg of BioCell Collagen daily had 76% less dryness/scaling, and their fine lines and wrinkles had reduced by 13.2% when compared to baseline levels. Additionally, both collagen levels and microcirculation were significantly improved. The outcome of this study was published in the Clinical Interventions in Aging journal (Schwartz, Park J, 2012)*.

2. In one of the most substantial studies of a skin health supplement, 1000 mg of BioCell Collagen® was found to visibly reduce common signs of skin aging, including lines and wrinkles, within 12 weeks of daily use. The findings reported in this randomized, double-blind, placebo-controlled clinical trial included a measurable improvement in signs of aging in women, represented by increased skin elasticity, reduction of crow's feet, and improvement in depth and number of fine lines and wrinkles. The full findings of the peer-reviewed study are published in the journal of Alternative Therapies in Health and Medicine. (Schwartz, Hammon KA, 2019)*.