Disease: Pneumococcus

This article, published in Pediatric Drugs, reviews the use of the 13-valent pneumococcal conjugate vaccine (PCV13) in infants, children, and adolescents. The author states the safety and reactogenicity of PCV13 to be generally similar to that of …

This report, published in the Weekly Epidemiological Record, provides essential background information on pneumococcal disease and gives the current World Health Organization position concerning the use of the 23-valent …

This online library gathers resources specifically related to adult immunization, providing healthcare providers and the general public with access to relevant resources that can be used in a clinic setting or for individual education. It includes …

Published in the journal Infection and Immunity, this article shows that C-Ps given intranasally with mucosal adjuvant increased the resistance of mice to experimental nasopharyngeal colonization by capsulated S. pneumoniae of serotype 6B.

Published in The Lancet Infectious Diseases, this article provides an overview of the diagnostic challenges of bacterial pneumonia and highlight the need for refining the current diagnostic approach to ensure adequate epidemiological surveillance of …

Pneumococcus, meningococcus and Haemophilus influenzae cause a similar spectrum of infections in the ear, lung, blood, and brain. They share cross-reactive antigens that bind to the laminin receptor of the blood-brain barrier as a molecular basis …

This article, published in The Lancet, releases new global burden of disease data for Streptococcus pneumoniae (pneumococcus), a leading cause of bacterial pneumonia, meningitis, and sepsis in children worldwide. The results also include data at the …

This article, published in the Pan American Journal of Public Health, estimates the annual burden of pneumonia, meningitis, and acute otitis media caused by pneumococcus in children less than five years of age in Latin America and the …

This report estimates the burden and costs of pneumococcal disease in Latin America and the Caribbean in order to inform national health authorities about disease burden and the economic value of implementing a pneumococcal …

This report reviews the successes and challenges of current global immunization programs, with a particular focus on: pneumonia, diarrheal disease, polio, measles, and rubella. It argues that while there is much to be applauded, there is a funding …

This article, published in Nature Medicine, reviews current successful vaccines and identifies their mechanisms of protection in the hopes of tackling the challenges posed by those infectious targets that have thus far escaped successful …

This report provides policy recommendations to help Tanzania reduce the impacts of pneumonia and diarrhea, including the use of available vaccines, to ensure all children have the chance to lead healthy lives.

This article, published in Vaccine, reviews recent developments in the area of using colonization as an endpoint for evaluating vaccine efficacy against Streptococcus pneumoniae. The authors also provide practical guidelines for estimation methods …

This article, published in Tropical Medicine & International Health, asserts that surveillance systems and techniques for diagnosing bacterial meningitis and pneumococcal disease in the African meningitis belt have improved greatly over the …

This review, published in Expert Review of Vaccines, looks at what has been learned from developing conjugate vaccines against Haemophilus influenzae type b, Streptococcus pneumoniae, and group C Neisseria meningitidis that could be useful for the …

To assess whether certain serogroups of Streptococcus pneumoniae are preferentially associated with specific disease manifestations, we analyzed all recent pneumococcal disease studies and assessed the relative frequency of isolation of each …

This supplemental issue of Clinical Infectious Diseases provides numerous articles on the surveillance and detection of pneumococcal and Haemophilus influenzae type b disease in developing countries. Topics include progress and challenges in disease …

This article, published in Current Opinion in Infectious Diseases, reviews new insights into the pathogenesis of pneumococcal disease. The authors discuss new mechanisms by which microbial factors govern the ability of pneumococcus to progress from …

Published in the New England Journal of Medicine, this study examined population-based data from the Active Bacterial Core Surveillance of the Centers for Disease Control and Prevention to evaluate changes in the burden of invasive disease, defined …

Published in The Lancet, this article assesses the effect of routine infant immunization with seven-valent pneumococcal conjugate vaccine (PCV7) on rates of all-cause and pneumococcal pneumonia admissions. ABSTRACT ONLY. (Learn how users in …

This fact sheet, issued by PATH, outlines PATH's pneumococcal vaccine project from a technical perspective, including an overview of PATH's vaccine development portfolio, research activities, and partners to support the development of vaccines …

This article, published in the Annals of the New York Academy of Sciences, discusses the development, clinical evaluation, and postlicensure impact of the 13-valent pneumococcal CRM(197) protein conjugate vaccine, PCV13, (Prevnar 13®). ABSTRACT …

This article, published in PLoS Medicine, provides an overview of the development and implementation of a national program for the management of severe and very severe childhood pneumonia in Malawi. Based on a successful delivery model used by the …

Published in FEMS Immunology and Medical Microbiology, this article examines serum anti-pneumococcal proteinase maturation protein A antibodies at 6, 12, 18 and 24 months of age, and showed that the age-related development of antipneumococcal …

Published in the journal Vaccine, this article reports on the development of a novel protein-based nasal vaccine against Streptococcus pneumoniae, in which three pneumococcal proteins were displayed on the surface of a non-recombinant, killed …

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