Opt-out profiles are automatically excluded during the delivery analysis in order to speed up deliveries (the error rate has a significant effect on delivery speed).

Note:

Opt-out applies to Profiles, as opposed to quarantine which is linked to an email address or phone number. Opting out a profile will therefore exclude from deliveries all the addresses linked to it.
If a user has two profiles in the database, he will still be targeted by deliveries as only one of his profiles is opt-out. To make sure all his adresses are excluded, add them to the quarantines addresses. For more on this, refer to
this page.