After a bomb explosion devastates a residential apartment building, special agents Maggie Bell and Omar Adom “OA” Zidan of the New York office of the Federal Bureau of Investigation investigate a possible war between rival gangs – that is, until their prime suspects are discovered brutally murdered.

After eight people are fatally poisoned at a deli in New York City, special agents Maggie Bell and OA Zidan trace the crime to an unlikely culprit and conduct a sting operation to prevent further attacks.

After a senator’s daughter is kidnapped and held for ransom, the FBI is called in to assist with finding the child before their time limit expires. However, in order to do so, they must dig into the senator’s past for clues to who did this to his family.

When an alt-right provocateur is murdered after giving a speech at a university in New York City, Maggie and OA investigate the school’s more extreme political groups and rely on OA’s sister, Amira, a student, for help.

When a judge and her daughter are murdered after she sentenced a man to life in prison, Maggie and OA search for the killer behind a possible retaliation. Dana has a vested interest in this case as she has a history with the victim.

When an alt-right provocateur is murdered after giving a speech at a university in New York City, Maggie and OA investigate the school's more extreme political groups and rely on OA's sister, Amira, a student, for help.

After an investigative journalist is murdered, the team uncovers information linking the suspect to past cases. The victim’s death also strikes a chord with Maggie, leaving her desperate for answers in regard to a traumatic event in her personal life.

A serial bomber appears to be targeting Wall Street’s elite. Maggie and OA search for a suspect who seems dead-set on revenge, while Dana deals with Spencer Briggs, a cocky profiler brought in to consult on the case.