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Figure 1: Structures of UNI, Abz-E2B and novel CYP707A inhibitors. Full size image Despite the potential value of Abz-E2B for imparting drought-stress resistance to plants, the synthetic yield of 1 is too low for practical uses in agriculture and horticulture. Here, we describe the design and preparation of the Abz-T compounds, and their effects on CYP707A and CYP701A both in vitro and in vivo. Results Design and synthesis of novel CYP707A inhibitors: Abz-T compounds The 1,2,4-triazolyl ring and the long ethylene glycol chain of Abz-E2B are critical for the effective inhibition of CYP707A.

To function as a specific inhibitor of CYP707A, previous studies indicated that an enlarged analogue of UNI requires a longer alkyl chain to increase the selectivity for CYP707A over CYP701A 22.