Lo studio aveva arruolato 41.654 donne negli Stati Uniti e in Puerto Rico, di età compresa tra i 35 e i 74 anni che avevano una sorella o sorellastra con diagnosi di cancro del seno, e aveva chiesto loro informazioni sull’uso del talco nei 12 mesi precedenti. Over the course of the study, no association was found between perineal talc use and subsequent diagnosis of ovarian cancer.7 While douching was more common among talc users, it was found that douching, but not talc, was associated with the increased risk of ovarian cancer during the Sister Study.7