No association has been found between the OPRM1 A118G SNP and pain perception in Chinese cancer patients.

result indicated that Caucasians carrying the G allele (AG + GG) of the A118G polymorphism in the mu-opioid receptor gene were more likely to be addicted to smoking compared with those with the AA homozygote

we have identified for the first time a potential mechanism that involves the essential splicing factor (show SLU7 Proteins) ASF/SF2 (show SRSF1 Proteins) through which morphine regulates splicing specificity of the MOR encoding gene, OPRM1.

OPRM1 A118G was not associated with nicotine craving in adolescent novice smokers.

Significant differences in mean dose consumption were seen among the genotypic groups of the OPRM1 A118G and UGT2B7 C802T variants. These variants were found to predict codeine consumption in the cohort overall and among Caucasians

Findings show that common OPRM1 intron 1 SNPs have replicable associations with heroin addiction, haplotype structure of rs3778150 and nearby SNPs may underlie the inconsistent associations between rs1799971 and heroin addiction

These investigations represent a reverse translational approach to investigating how the OPRM1 A118G polymorphism alters mesolimbic responses to opioids, which may elucidate mechanisms influencing both opioid and alcohol abuse in human populations

Study found that the OPRM1 A118G polymorphism produces significant variation in cortisol reactions to psychological stress among women

Mouse (Murine) Opioid Receptor, mu 1 (OPRM1) interaction partners

findings indicate that G9a (show EHMT2 Proteins) contributes critically to transcriptional repression of MORs in primary sensory neurons in neuropathic pain. G9a (show EHMT2 Proteins) inhibitors may be used to enhance the opioid analgesic effect in the treatment of chronic neuropathic pain.

In addition to generating a series of prototypic seven transmembrane domain G protein-coupled receptors, Oprm1 produces a set of truncated splice variants containing only six transmembrane domains through which selected opioids mediate a potent analgesia.

These investigations represent a reverse translational approach to investigating how the OPRM1 A118G polymorphism alters mesolimbic responses to opioids, which may elucidate mechanisms influencing both opioid and alcohol abuse in human populations

Results suggested that the MOPR A118G SNP results in a loss of receptor function in the mouse hippocampus

Study demonstrates a functional role for Mu Opioid Splice Variant MOR-1K in a murine model of opioid-induced hyperalgesia.

findings suggest a role for OPRM1 variation in the expression of attachment behavior, especially as a function of separation from the caregiver

Mu Opioid Receptor 1 (OPRM1) Protein Profile

Protein Summary

This gene encodes one of three opioid receptors. The mu opioid receptor is the principal target of endogenous opioid peptides and opioid analgesic agents such a s beta-endorphn and enkephalins. The NM_001008503.1:c.118A>G allele had been associated with opioid and alcohol addiction and variations in pain sensitivity but evidence is conflicting. Multiple transcript variants encoding different isoforms have been found for this gene.