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FAK2 is a cytoplasmic tyrosine kinase involved in calcium-induced regulation of ion channels and activation of the MAP kinase signaling pathway. It regulates reorganization of the actin cytoskeleton, cell polarization, cell migration, adhesion, spreading and bone remodeling. The protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity