A Texas judge’s stunning declaration that Obamacare is unconstitutional not only kneecaps the health care law, it would also cripple President Donald Trump’s entire health care agenda.

Trump wants lower drug prices, drastic action on the opioid crisis and protection for people with pre-existing conditions. Those are the parts of the law many Republicans do want to keep, but with the entire law invalidated — pending appeal — Trump and Republicans are trying to figure out how to live with a judicial ruling they kind of wanted, but didn’t want in such a big way.

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The blunt force of the Texas ruling, without consideration for the dozens of popular provisions sprinkled throughout the law, shows just how intertwined the Affordable Care Act has become as part of the American health care system.

And nobody on the Republican side has a clear plan on what to do now.

Nothing is changing yet. But if the ruling does stand following appeals, or if the Trump administration reverses course and refuses to enforce more parts of the law, because of the Texas case, seniors would immediately be on the hook for thousands of dollars in additional drug spending. Millions of Americans would lose Medicaid coverage — the largest payer of addiction treatment in the country.

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Meanwhile, the administration would also lose access to a powerful weapon for reforming the U.S. health system — the CMS Innovation Center. Created by the health law, it gives the government broad powers to test new health policies, whether it be doctor payment models or new cancer drug pricing ideas, and scale them up nationally without congressional approval.

But without Obama’s signature law, the Trump administration would be left scrambling to achieve its health care goals, while simultaneously dealing with a system thrust into chaos.

Trump’s health department has identified four main priorities: lowering the cost of prescription drugs, ending the opioid crisis, improving health insurance’s availability and affordability, and moving the health system to one that pays for the quality of services offered, not the quantity. And even as the Trump administration bashes the ACA, it’s leaning hard on it to accomplish these goals.

The court’s decision “is a cloud over the efforts to keep moving forward on health reforms and it’s going to create confusion and probably delay,” said John Rother, president and CEO of the National Coalition on Health Care, adding, “Now I wonder how we’re going to be able to keep up the momentum” on issues such as drug pricing and payment reform.

“The breadth of the act is extraordinarily sweeping, and it will affect every aspect of the health system if it’s struck down, including many things this administration has publicly championed or made priorities,” said Rachel Sachs, a health policy expert and law professor at Washington University in St. Louis.

Without Obamacare, Americans would see drug spending go up with seniors and state governments taking the brunt of the blow.

It’s the exact opposite of Trump’s extensive blueprint on lowering drug prices. The goal, the president said in May, is to take “the most sweeping action in history to lower the price of prescription drugs for the American people.”

Without Obamacare, many seniors would likely spend around $2,000 or more in out-of-pocket drug costs each year, said Juliette Cubanski, associate director of Medicare policy at the Kaiser Family Foundation. That’s because the ACA required drugmakers to provide big discounts to seniors in the coverage gap phase of their Medicare Part D benefit. In 2016, more than 5 million Medicare recipients reached the coverage gap, with drugmakers providing $5.7 billion in discounts to offset the costs of their medicines, Cubanski said.

States’ Medicaid programs, which are a big part of state budgets, would also take a hit because drug companies could go back to giving them the smaller pre-Obamacare discounts on medications, and these discounts wouldn’t apply to Medicaid managed care programs.

Meanwhile, the biosimilar market, which Trump’s FDA chief, Scott Gottlieb, has spent months trying to invigorate and improve, would collapse as Obamacare established the pathway to bring cheaper versions of biologic medicines to patients. Those drugs are often the most expensive medicines in the U.S.

“As if it’s not challenging enough already for biosimilars to get approved and actually come to market in this country, this would make it even more challenging,” Cubanski said.

At the same time, Trump’s HHS would have a much more difficult time implementing its new ideas to lower the cost of medicines, like an October plan to tie the cost of physician-administered drugs — things like chemotherapy or other infused medications — in Medicare to the lower prices paid by other developed countries.

Without Obamacare’s Innovation Center, Trump would likely need congressional approval to implement such a sweeping national test on drug prices — a long shot given recent skepticism from his own party, the drug industry, and patient and doctor groups.

The Innovation Center is also a key component of the Trump administration’s plan to move the health system away from paying for the sheer number of services provided, and instead incentivize good care — and it could unveil new projects as soon as the first three months of 2019.

HHS Secretary Alex Azar teased their release, saying on Wednesday that “the biggest things that we’re going to be launching, coming soon, are going to be these demonstrations that Adam Boehler — our head of the Center for Medicare and Medicaid Innovation — has been working on.”

“There’s a lot of basic payment plumbing in the ACA. Ripping it out would be enormously disruptive,” Nicholas Bagley, a professor of law at the University of Michigan Law School, wrote in an email.

Doctors and hospitals are still committed to the payment reform effort, several sources told POLITICO, as they’ve already devoted ample time, money and resources into moving toward value-based care. CMMI projects have been underway for years, so eliminating the center would, as Bagley put it, still be an “enormous procedural headache.”

There is a possibility that a higher court could keep parts of the health law, such as CMMI, but rule otherparts of Obamacare invalid, like the popular protections for pre-existing conditions. While the Trump administration has committed to ensuring those people would still have health coverage, it hasn’t offered any suggestions on how to preserve those protections in a concrete waywithout Obamacare — which Democrats capitalized on during the midterm elections.

On the opioid front,Trump has repeatedly promised to end the scourge of addiction. But experts say any rollback in Medicaid coverage, the biggest payer of behavioral health care, would almost certainly set back his efforts to address the crisis killing 115 Americans every day.

The administration and Congress have invested billions to expand access to treatment, but work funded by those grants would likely be dwarfed by coverage losses if Medicaid expansion goes away under Friday’s ruling. Roughly 1.2. million people with addiction and mental health issues are covered under Medicaid expansion.

Medicaid is the “bedrock” of addiction treatment, said Andrew Kessler, founder of Slingshot Solutions, a consulting firm specializing in behavioral health. “You can’t do a single thing to inhibit Medicaid If you say you want to see improvement in substance use disorder treatment. The two don’t go together.”

Advocates say scrapping the law would also be harmful to the tens of thousands of people in the private insurance market seeking help for drug addiction, since Obamacare requires insurers to cover treatment as part of 10 essential health benefits.

“Any backtracking on this would be a significant blow to patients,” said Mark Covall, president and CEO of the National Association for Behavioral Healthcare.

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