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Cardiomyopathy

1.
• Cardiomyopathies
• Definition
“A primary disorder of the heart muscle that causes abnormal myocardial performance and is not
the result of disease or dysfunction of other cardiac structures … myocardial infarction, systemic
hypertension, valvular stenosis or regurgitation”
Causes
 Ischemic
 Valvular
 Hypertensive
 Inflammatory
 Metabolic
 Inherited
 Toxic reactions
 Peripartum
Dilated Cardiomyopathy
The cause of dilated cardiomyopathy often isn't known. As many as one-third of the people who have
dilated cardiomyopathy inherit it from their parents.
Certain diseases, conditions, and substances also can cause the disease, such as:
 Coronary heart disease, heart attack, high blood pressure, diabetes, thyroid disease, viral hepatitis,
and HIV
 Infections, especially viral infections that inflame the heart muscle
 Alcohol, especially if you also have a poor diet
 Complications during the last month of pregnancy or within 5 months of birth
 Certain toxins, such as cobalt
 Certain drugs (such as cocaine and amphetamines) and two medicines used to treat cancer
(doxorubicin and daunorubicin)
Hypertrophic Cardiomyopathy
Hypertrophic cardiomyopathy (HCM) usually is inherited. It's caused by a mutation (change) in some of
the genes in heart muscle proteins. HCM also can develop over time because of high blood pressure or
aging.
Other diseases, such as diabetes or thyroid disease, also can cause HCM. Sometimes the cause of the
disease isn't known.

2.
Restrictive Cardiomyopathy
Certain diseases, conditions, and factors can cause restrictive cardiomyopathy, including:
 Hemochromatosis . This is a disease in which too much iron builds up in your body. The extra
iron is toxic to the body and can damage the organs, including the heart.
 Sarcoidosis . This disease causes inflammation and can affect various organs in the body. an
abnormal immune response may cause sarcoidosis.
 Amyloidosis. This is a disease in which abnormal proteins build up in the body's organs,
including the heart.
 Connective tissue disorders.
 Some cancer treatments, such as radiation and chemotherapy.
Major Risk Factors
Certain diseases, conditions, or factors can raise your risk for cardiomyopathy. Major risk factors include:
 A family history of cardiomyopathy, heart failure, or sudden cardiac arrest (SCA)
 A disease or condition that can lead to cardiomyopathy, such as coronary heart disease, heart
attack, or a viral infection that inflames the heart muscle
 Diabetes or other metabolic diseases, or severe obesity
 Diseases that can damage the heart, such as hemochromatosis, sarcoidosis, or amyloidosis
 Long-term alcoholism
 Long-term high blood pressure
• WHO Classification
• Unknown cause
(primary)
– Dilated
– Hypertrophic
– Restrictive
– unclassified
• Specific heart muscle disease (secondary)
– Infective
– Metabolic
– Systemic disease
– Heredofamilial
– Sensitivity

5.
• anticoagulation for EF <30%, history of thromboemoli, presence of mural thrombi
• intravenous dopamine, dobutamine and/or phosphodiesterase inhibitors
• cardiac transplantation
• Hypertrophic Cardiomyopathy
• Hypertrophic Cardiomyopathy
• Hypertrophic cardiomyopathy (HCM) is very common and can affect people of any age. About 1
out of every 500 people has HCM. It affects men and women equally.
• HCM is a common cause of sudden cardiac arrest (SCA) in young people, including young
athletes.
• HCM occurs if heart muscle cells enlarge and cause the walls of the ventricles (usually the left
ventricle) to thicken. Despite this thickening, the ventricle size often remains normal. However,
the thickening may block blood flow out of the ventricle. If this happens, the condition is called
obstructive hypertrophic cardiomyopathy.
• Sometimes, the septum thickens and bulges into the left ventricle. This also can block blood flow
out of the left ventricle. (The septum is the wall that divides the left and right sides of the heart.)
• If a blockage occurs, the ventricle must work hard to pump blood to the body. Symptoms can
include chest pain, dizziness, shortness of breath, or fainting.
• HCM also can affect the heart's mitral (MI-trul) valve, causing blood to leak backward through
the valve.
• Sometimes the thickened heart muscle doesn't block blood flow out of the left ventricle. This is
called nonobstructive hypertrophic cardiomyopathy. The entire ventricle may thicken, or the
thickening may happen only at the bottom of the heart. The right ventricle also may be affected.
• In both types of HCM (obstructive and nonobstructive), the thickened muscle makes the inside of
the left ventricle smaller, so it holds less blood. The walls of the ventricle also may stiffen. As a
result, the ventricle is less able to relax and fill with blood.
• These changes can raise blood pressure in the ventricles and the blood vessels of the lungs.
Changes also occur to the cells in the damaged heart muscle. This may disrupt the heart's
electrical signals and lead to arrhythmias.
• Some people who have HCM have no signs or symptoms. The disease doesn't affect their lives.
Others have severe symptoms and complications. For example, they may have shortness of
breath, serious arrhythmias, or an inability to exercise.
• Rarely, people who have HCM can have SCA during very vigorous physical activity. The
physical activity can trigger dangerous arrhythmias. If you have HCM, ask your doctor what
types and amounts of physical activity are safe for you.
• Restrictive Cardiomyopathy
• Restrictive cardiomyopathy tends to mostly affect older adults. With this disease, the ventricles
become stiff and rigid. This happens because abnormal tissue, such as scar tissue, replaces the
normal heart muscle.
• As a result, the ventricles can't relax normally and fill with blood, and the atria become enlarged.
Over time, blood flow in the heart is reduced. This can lead to problems such as heart failure or
arrhythmias.
•
• First described by the French and Germans around 1900
• uncommon with occurrence of 0.02 to 0.2%

9.
Your doctor may suggest lifestyle changes to manage a condition that's causing your cardiomyopathy.
These changes can help reduce symptoms.
Healthy Diet and Physical Activity
A healthy diet and physical activity are part of a healthy lifestyle. A healthy diet includes a variety of
fruits, vegetables, and grains; half of your grains should come from whole-grain products.
Choose foods that are low in saturated fat, trans fat, and cholesterol. Healthy choices include lean meats,
poultry without skin, fish, beans, and fat-free or low-fat milk and milk products.
Choose and prepare foods with little sodium (salt). Too much salt can raise your risk of high blood
pressure. Recent studies show that following the Dietary Approaches to Stop Hypertension (DASH)
eating plan can lower blood pressure.
Choose foods and beverages that are low in added sugar. If you drink alcoholic beverages, do so in
moderation.
Aim for a healthy weight by staying within your daily calorie needs. Balance the calories you take in with
the calories you use during physical activity. Be as physically active as you can.
Some people should get medical advice before starting or increasing physical activity. For example, talk
with your doctor if you have a chronic (ongoing) health problem, are on medicine, or have symptoms
such as chest pain, shortness of breath, or dizziness. Your doctor can suggest types and amounts of
physical activity that are safe for you
 Quitting smoking
 Losing excess weight
 Avoiding the use of alcohol and illegal drugs
 Getting enough sleep and rest
 Reducing stress
 Treating underlying conditions, such as diabetes and high blood pressure