With the shifting demographics towards older age, there is a major concern for age-related disorders. 90% of individuals dying each year are due to age-related causes. Understanding the genome, epigenome and proteome between healthy and diseased state of these individuals pave a way for unravelling bio-markers for early diagnosis and/or therapeutics for various diseases. Our goal is to find these underlying players that change the micro-environmental niche differently in a diseased state during the developmental process of aging and hence are responsible for these age related-disorders. We are currently focusing on understanding the pathomechanism of two neurodegenerative eye disorders (Glaucoma, the leading cause of irreversible World Blindness and Corneal Endothelial Dystrophies) as well as Cancer using a pleothora of cellular, biochemical, genetics, genomics and molecular biology techniques involving human samples, Drosophila models as well as in vitro cell lines.