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THANK YOU FOR SUBSCRIBING TO RECEIVE ADDITIONAL INFORMATION ABOUT DUOPA.

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TERMS AND CONDITIONS

AbbVie Inc. is providing this service to help patients find a doctor in their area who has prescribed Duopa.

No fees have been received by or paid to doctors for inclusion in this specialist locator directory. Inclusion of a physician in this directory does not represent an endorsement by or a recommendation from AbbVie Inc., nor does it imply that the doctor on the list will determine that Duopa is right for you.

You are ultimately responsible for the selection of a physician and it is an important decision that you should consider carefully. This tool is just one source of information available to you.

AbbVie Inc. is the maker and marketer ofDUOPA® (carbidopa and levodopa) enteral suspension.

Exercise is an important part of treatment for people with Parkinson's disease. It can include being active, stretching, and practicing good posture. Always check with your doctor before starting an exercise program.

Here are some suggestions about how to incorporate exercise into your daily routine:

Set personal activity goals with your doctor to keep on track

Ask your healthcare team what kinds of activities could be right for you. Be sure to choose only those that you are safe doing

Start with activities you enjoy. Get some fresh air. Stay indoors and stretch, or practice yoga. You and your doctor can decide what to try

Choose the time of day when you have the most energy

Pace yourself. Know your limit and never overdo it

Change up your activities from time to time, and try new activities to avoid boredom

Include your carer as part of your exercise routine

Try a group activity to stay motivated and develop your support network

Important Safety Information

What is the most important safety information I should know about DUOPA?

Stomach and intestine (gastrointestinal) problems and problems from the procedure you will need to have to receive DUOPA (gastrointestinal procedure-related problems) may occur. Some of these problems may require surgery and may lead to death.

Your healthcare provider will talk to you about the stoma procedure.
Before the stoma procedure, tell your healthcare provider if you ever had a surgery or problems with your stomach.

Talk to your healthcare provider about what you need to do to care for your stoma.
After the procedure, you and your healthcare provider will need to regularly check the stoma for any signs of infection.

Symptoms of infection may include: drainage, redness, swelling, pain, or feeling of warmth around the small hole in your stomach wall (stoma).

Tell your healthcare provider right away if you have any of the following symptoms of stomach and intestine problems and gastrointestinal procedure-related problems: stomach (abdominal) pain; constipation that does not go away; nausea or vomiting; fever; blood in your stool; or a dark tarry stool.

Do not take DUOPA if you currently take or have recently taken (within 2 weeks) a medication for depression called a non-selective monoamine oxidase (MAO) inhibitor. Ask your healthcare provider or pharmacist if you are not sure if you take an MAO Inhibitor.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Using DUOPA with certain other medicines, including medications for high blood pressure, MAO inhibitors, antipsychotics, metoclopramide, isoniazid, and iron or vitamin supplements, may cause serious side effects. High-protein foods may affect how DUOPA works. Tell your healthcare provider if you change your diet.

DUOPA may cause serious side effects. Talk to your doctor before starting DUOPA and while on DUOPA if you have had or have any of these:

Falling asleep during normal daily activities without warning. DUOPA may cause you to fall asleep while you are doing daily activities such as driving, which may result in an accident. This can happen as late as one year after starting DUOPA.
Do not drive or operate machinery until you know how DUOPA affects you. Tell your healthcare provider if you take medicines that can make you sleepy, such as sleep medicines, antidepressants, or antipsychotics.

Low blood pressure when you stand or sit up quickly. After you have been sitting or lying down, stand up slowly to help reduce dizziness, nausea, sweating, or fainting until you know how DUOPA affects you.

Seeing, hearing, or feeling things that are not real (hallucinations).

Unusual urges. Some people taking medicines for Parkinson’s disease, including DUOPA, have reported urges such as excessive gambling, compulsive eating, compulsive shopping, and increased sex drive.

Depression and suicide. DUOPA can cause or worsen depression. Pay close attention to changes in your mood, behavior, thoughts, or feelings. Call your healthcare provider right away if you feel depressed or have thoughts of suicide.

Uncontrolled sudden movements (dyskinesia). If you have new dyskinesia or your dyskinesia gets worse, tell your healthcare provider. This may be a sign that your dose of DUOPA or other Parkinson’s medicines may need to be adjusted.

Progressive weakness or numbness or loss of sensation in the fingers or feet (neuropathy).

Heart attack or other heart problems. Tell your healthcare provider if you have experienced increased blood pressure, a fast or irregular heartbeat, or chest pain.

Parkinson’s disease patients are at an increased risk of developing
melanoma, a form of skin cancer. See your healthcare provider for regular skin examinations when taking DUOPA.

Worsening of the increased pressure in your eyes (glaucoma). The pressure in your eyes should be checked after starting DUOPA.

Do not stop using DUOPA or change your dose unless you are told to do so by your healthcare provider. Tell your healthcare provider if you develop withdrawal symptoms such as fever, confusion, or severe muscle stiffness.

The most common side effects of DUOPA include: complications of tubing placement procedure, swelling of legs and feet, nausea, high blood pressure (hypertension), depression, and mouth and throat pain.

Please see the full Prescribing Information including Medication Guide for additional information about DUOPA. Talk to your healthcare provider if you have questions.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

If you cannot afford your medication, contact www.pparx.org for assistance.

Use

DUOPA (carbidopa and levodopa) enteral suspension is a prescription medicine used for treatment of advanced Parkinson’s disease. DUOPA contains two medicines: carbidopa and levodopa.

IMPORTANT SAFETY INFORMATION

What is the most important safety information I should know about DUOPA?

Stomach and intestine (gastrointestinal) problems and problems from the procedure you will need to have to receive DUOPA (gastrointestinal procedure-related problems) may occur. Some of these problems may require surgery and may lead to death.

Your healthcare provider will talk to you about the stoma procedure.
Before the stoma procedure, tell your healthcare provider if you ever had a surgery or problems with your stomach.

Talk to your healthcare provider about what you need to do to care for your stoma.
After the procedure, you and your healthcare provider will need to regularly check the stoma for any signs of infection.

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