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an Online Community created to discuss Phalloplasty - the surgical enlargement of the penis.
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my bp is normal, i'm in the 25-35 y/o age bracket. male. spanish decent. fast metabolism. normal bmi. weekly hiking/surfing. some family hx of htn/diabetes. i still eat my bacon burgers. What i'm getting at is there are numerous variables that could influence bp. Lifestyle and stress are the main contributors to hypertension. some drugs have hypertension as a side affect.

there's a nice powerpoint presentation on blood pressure linked below. i don't see pmma as causing hypertension unless it obstructs blood vessels, if it entered the circulatory system i'd be more concerned with it causing a stroke, but since the size of each bead is unique i'm not confident it would cross the blood brain barrier. but, would the lymphatic system have access to absorbing pmma? absolutely, macrophages would migrate the foreign filler to the closest lymph node were it develops into a fbg. Inguinal lymphodenopathy would be an initial diagnosis before ruling out lymphoma. CT and a biopsy is conducted there after. I only know of the inguinal region being of concern for penile pmma patients. Casavantes has some pmma in his biceps, if he developed fbgs in his lymph nodes, it would be found in his axillary region or neck. Did you find any peer reviewed articles on the subject buttercups?

The BBB's (Blood Brain Barrier) width is 38-64 nm (Thorne RG, Nicholson C. In vivo diffusion analysis with quantum dots and dextrans predicts the width of brain extracellular space. Proc. Natl Acad. Sci. USA103(14),5567–5572 (2006)). The size of the pmma beads for metacrill/Newplastic range from 0.2-60/0.2-70 micrometers, 1 micrometer = 1,000 nm (nanometers). So based upon the particle size I feel that a stroke caused by rouge pmma beads is unlikely, but in human health and science, there are always statistical outliers. It extremely hard to rule out the impossible because there is inconsistent size of these bead particles. If 90% were 40-50 micrometters, maybe we'd be in the clear, but the manufacturing process seems to be the only flaw here. I'd really like to see how pmma beads are made and what quality control tests are conducted by the bioengineering company to ensure top product quality. I think I had these same questions when we had EP around, not much progress in these last few years.

No peer reviewed articles. However, it suddenly dawned on me that for people who already have arterial sclerosis, PMMA might aggravate/accelerate the condition if beads were to get into the blood stream and get stuck in arterial plaque. This might cause blood pressure to rise slowly over time as more beads were lodged into plaque "dams".

But I'm not a doctor and I don't have much knowledge of biology, generally. I'm more of a systems person.

Disclaimer: what worked for me may not be suitable for another person. We all have different bodies, medical history, etc. What worked for me now could change in the future.

Systems as in computer science/engineering? My genetics professor was a CS guy and he knew his shit. I'm sure you would stand well in any bio or chem class, you just have to have the patience for wet labs and maybe the redundant learning curve.

I think if PMMA was injected in the blood stream in the penis area, it will cause immediate and severe reaction locally and of course will cause more problems as it travels through the blood stream hence there will be immediate recognition of the cause of the problem...Scary stuff and I hope it never happens to any one.

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