Although most efforts in cancer prevention and treatment strategies have largely focused on pharmacologic therapies, these are costly and can result in long-term morbidity and even mortality. Therefore, novel methods to improve outcomes, especially those that can improve quality of life and offer other health benefits, are an area of continued investigation.

In this topic, we will review the evidence that links diet, physical activity, and body weight to cancer-related outcomes and will provide an overview of the many studies that have looked at the feasibility and potential benefits of energy balance interventions in cancer survivors. In addition, we provide consensus-based recommendations for cancer survivors.

Topics addressing diet, physical activity, and weight in patients without a history of cancer are discussed separately:

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