Roethlisberger and the Steelers take on the Redskins in what could be a very favorable matchup. The Redskins give up the most passing yards per game in the league, giving up 328 yards a week. In fact, the lowest number of passing yards the Skins have given up in a game is 299, to Josh Freeman.

The Redskins passing defense, obviously, can be exploited. Big Ben is chomping at the bit at this matchup. Look for the Steelers to try to go deep early and often. Mike Wallace and Antonio Brown will be the beneficiaries. Roethlisberger will have a huge game on Sunday.

If the Redskins have the worst passing defense, then the New Orleans Saints are not far behind. They give up an average of 304 passing yards per game, good for 30th in the league.

This all leads to a very nice matchup for Peyton Manning and the Broncos. Manning is a must-start this week. Josh Freeman, Philip Rivers and Aaron Rodgers have averaged about 365 yards and three touchdowns in their matchups against the Saints.

Manning could even top that. He's having a tremendous season, as he's thrown for 1,808 yards, 14 touchdowns and only four interceptions through six games. He's poised for a big game Sunday.

Rivers has had an undoubtedly erratic season. But he could be due for a nice performance this week. The Chargers are going up against the Browns, who give up almost 277 passing yards per game, which is 26th-best in the league. Cleveland has allowed multiple touchdowns in every game they've played so far.

Rivers has six touchdowns in his last three games. With Antonio Gates slated to come back, look for Rivers to have a big week.

Andrew Luck

Andrew Luck is certainly going through the requisite rookie struggles, but he's shown enough flashes to justify his selection as the first overall pick. Luck is going up against the Titans, who have allowed multiple passing touchdowns in all but one game this season. They give up 281 passing yards per game.

Luck is poised for a big game. He had a solid week last week, and going up against Tennessee's porous pass defense could lead to a breakthrough. The Titans have given up the third-most fantasy points this season, depending on the scoring system, and have given up at least 15 points in every game to quarterbacks. Luck is a solid play.

Brandon Weeden

Looking for a sleeper pick, especially in two-quarterback leagues? Look no further. Despite his early-season struggles, Weeden is an improving player who is trending upward. In his last three starts, Weeden has scored more than 15 points.

The Chargers do not have a good pass defense. They give up 268 passing yards a game. In their last two games, the Chargers have given up a combined 679 passing yards and seven touchdowns. As Weeden continues to improve, look for him to have a big week against a bad San Diego pass defense.