Maggot debridement therapy (MDT) is a cost-effective method for debriding chronic wounds. Though numerous studies have shown its efficacy and superiority over conventional wound care methods, its repulsiveness impedes its widespread use. Bio-SurgTX is a topical cream formulated from proteolytic enzymes expressed and purified from Lucilia sericata (green bottle fly) larvae using recombinant DNA technology. Trials show that the resulting product is comparable to MDT and highly efficacious over conventional therapy. Its very high acceptance rates make it a viable commercial treatment that could significantly reduce health care costs and replace traditional MDT and conventional therapies.