Despite the availability of effective preventative and therapeutic strategies, methicillin-resistant Staphylococcus aureus (MRSA) remains a major cause of health care–associated and, more recently, community-acquired infections. Since the introduction of methicillin in 1959, epidemics due to different clones of MRSA have occurred in diverse geographic regions.1 The result has been the persistence of MRSA as an important pathogen worldwide.