I've decided on Axiom but having a tough time between the M3 or M22. I'm going to power them with a Denon AVR 3300 and probably add the E125 sub to the bottom end. My room is 14x11 and the right side opens to a 20x11 room. The primary concern is two channel music but it will also exist as HT. Any thoughts?

Both will work well for your environment and amplification. The M22 will give you more overall output and a little more detail in the mid range. If size and cost are not a concern, I would recommend the M22s.