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Yuck it up with funny guys and gals from around the nation during Theatre 99’s 10th annual festival of improv, stand-up, and sketch comedy. Choose from some 35 shows, including headliner Wyatt Cenac’s on January 16 and a finale extravaganza on the 19th. Locations, times, & prices vary. (843) 853-6687, www.charlestoncomedyfestival.com