- Cutaneous dissease- Photochromogen- Natural resevoir is fresh and salt water due to infected fish or marine life- Transmission by contact with contaminated water and organism entry by trauma or small breaks in the skin

- Assessment of cell-mediated immunity- Turberculin skin test: injection of TB protein under skin, skin will react to the antigens by developing a firm red bump at the site within 2 days if positive (can't detect if latent or active)- Lepromin skin test: determines type of leprosy by injection of inactivated leprosy bacillus- QuantiFERON-TB test: detects latent TB

- Most common two drug therapy: Isoniazide (INH) and rifampin for 9 months (if pyrazinamide is added in beginning, the total time is only 6 months)- Resistance due to non-compliant patients- Multidrug resistant Mtb (resistant to at least 1 frontline drug)- Extensively multidrug resistant Mtb (more toxic to pt)- Profoundly multidrug resistant Mtb (resistant to everything in which extensive surgery is the only thing to save the pt)