OSHA does not have a PEL for propylene glycol monomethylether acetate (PGMEA).

Because of the rapid hydrolysis of PGMEA by blood and liver esterases, it has been suggested that the toxicology of PGME can serve as a surrogate for PGMEA, except for possible additional upper respiratory irritation by acetic acid resulting from the hydrolysis of PGMEA.

14C-labeled PGMEA given to rats by either the oral or inhalational routes was metabolized >50% to carbon dioxide. About 25% of the dose was excreted in the urine as both free and conjugated 1-methoxy-2-propanol, and as the O-demethylated metabolite, 1,2-propanediol.