Genome Property Definition Page

Accession

GenProp0148

Name

release factor 2 programmed frameshift

Type

SYSTEM

Description

Peptide chain release factor 2, product of the prfB gene (RF2, or PrfB), often has a programmed frameshift. When enough RF2 is present, translation ends at a UGA (amber) stop codon soon after the start. Without sufficient RF2, a translational frameshift occurs, allowing RF2 to be made. UGA codons also play a role in selenocysteine incorporation, but the programmed frameshift in the prfB gene appears much more widespread than selenocysteine incorporation.