..These findings contrast with those of others who have established the G20210A variant as a thrombophilic risk factor; and emphasize the complex nature of the multigenic pathogenesis of thrombophilia...

Heritability of plasma concentrations of clotting factors and measures of a prethrombotic state in a protein C-deficient family

..Identification of the unknown mutation(s) promises to reveal a new genetic risk factor for thrombophilia, contribute to our understanding of the blood clotting mechanism, and expand our knowledge of the diversity of oligogenic disease...

A genome search for genetic determinants of markers of protein C activation