By 2005, he had appeared in 43 feature films such as Sommersby, Something To Talk About, Assassins, Rosewood, I Know What You Did Last Summer, From Dusk Til Dawn II, I Still Know What You Did Last Summer, Austin Powers: The Spy Who Shagged Me, and Songcatcher.

Seven of the films Muse has appeared in have together grossed over 850 million dollars by 2005. Muse has also appeared on television. Eight made for television movies including Blind Vengeance and Justice in a Small Town; and seven television series, American Gothic, The Young Indiana Jones Chronicles, Matlock, Lazarus Man, JAG, Walker, Texas Ranger, and a former regular cast member on Fox's Prison Break. Muse also gave a performance with Jennifer Love Hewitt as a special guest on Saturday Night Live. In 2005 he appeared as guest star in NCIS