Asia Pacific & Middle East

Cannabis 2018

Sessions/Tracks

Track: 1- Cannabis

Marijuana is a plant whose scientific name is Cannabis sativa. Its leaves, seeds, stems, and/or roots are consumed by marijuana users for the purpose of feeling intoxicated ("high"). Although the plant contains hundreds of compounds, the one that has major intoxicating effects is called tetrahydrocannibinol (THC). Although medical marijuana is legal in a few states of the United States, it is one of many illegal drugs in most jurisdictions. Marijuana is the most commonly abused illegal substance worldwide. While the number of people who use marijuana at any one time does not seem to have increased in the past decade, the number of people who have a marijuana-related disorder has increased significantly. This seems to be particularly true for elderly individuals as well as for young Hispanic and African-American adults. In teens, boys remain more likely than girls to smoke or otherwise use marijuana

Cannabis belongs to the genus Cannabis in the family Cannabaceae and may include three species, C. sativa, C. indica, and C. ruderalis, (APG II system) or one variable species. It is typically a dioecious (each individual is either male or female) annual plant. C. sativa and C. indica generally grow tall, with some varieties reaching 4 meters, or 13 feet. Female plants produce tetrahydrocannibinol (THC) (up to 29% by weight) as the season changes from summer to autumn. C. ruderalis is very short, produces only trace amounts of THC, but is very rich in cannabidiol (CBD), which may be 40% of the cannabinoids in a plant and is an antagonist to THC, and it flowers independently of the photoperiod and according to age. However, commercial cross-bredhybrids containing both ruderalis, indica and/or sativa genes exist (usually called auto flowering)

Increasing legitimacy and legality of medicinal plants nationwide has created great demand for qualified technical personnel and great opportunity for the skilled entrepreneur in the cannabis, herbal extract, and natural product industries. Medicinal Plant Chemistry at Northern Michigan University is the only 4-year undergraduate degree program of its kind designed to prepare students for success in the emerging industries relating to medicinal plant production, analysis, and distribution. The required coursework provides a foundation in chemistry and plant biology, with a capstone research experience involving experimental horticulture and instrumental analysis of natural products, while focus tracks allow students to explore their interests in the relevant areas of business and accounting (Entrepreneurial Track) or advanced topics in chemistry and biology (Bio-analytical Track).

Extraction of cannabis is a simple process, which people have used for centuries. There are many records of people using cannabis tea, hash or tinctures in ancient times. The first mention of hash dates back to the year 900 in Arabia, where people used to eat it rather than smoke it. At the beginning of the second millennium, hash was spread all over the Middle East. It is likely that Napoleon and his troops brought hash to Europe from Egypt around the 1800s. A French doctor, Louis Albert-Roche, recommended the use of hashish in the 1840s. Later in Paris, there was a Club des established, where famous writers like Balzac, Baudelaire and Hugo enjoyed the exotic hashish which may have inspired some of their great masterpieces. People used cannabis tinctures up until 1942 in the USA and up until 1970 in the UK. Nowadays, the science behind cannabis extraction has matured significantly, with more technologically demanding methods being used. The reason people carry out extractions is simple, and remains the same after centuries of practice — the final product is much more potent than the fresh herb, and there are more of the desired compounds present. Therefore it is easier to know the dosage. For example, fresh herb usually contains up to 30 % of THC and 24 % CBD, compared to concentrates which can be up to 99 % pure.

Derived from the hemp plant, Cannabis sativa – marijuana – is a psychoactive sedative drug. Its leaves and buds can be smoked, taken in food, brewed in tea or taken in concentrated liquid form. The resins from the marijuana plant can be used to make a form of the drug called hashish. As illegal use of marijuana becomes increasingly widespread, addiction experts are concerned about the drug’s long-term effects on mental function and emotional health.

Cannabis is the world’s most widely used illicit drug with about 10% of young adults in developed countries being regular users. Behavioral and pharmacological studies indicate that both acute and chronic exposure to cannabinoids is associated with impairments in a range of cognitive processes. Neuroimaging methods have provided powerful tools to study the in vivo effects of cannabis on brain function. While there are brain functional differences, such as reduced resting-state, prefrontal and anterior cingulate cortex blood flow, between cannabis users and controls in healthy populations, brain structural abnormalities related to cannabis use have been reported inconsistently . In contrast, a neurotoxic effect (e.g. shrinkage of neuronal cell bodies and nuclei) of cannabis in animals has been confirmed in many cases. It is assumed, that tetrahydrocannibinol (THC), the main psychoactive substance in cannabis, is the neurotoxic substance. The effects of cannabis on brain structure and function are of particular interest in psychosis patients, as cannabis is known to be a risk factor for psychosis and is widely used in patients with psychosis [17]. There is evidence from structural imaging studies showing robust volume reductions in front-temporal cortices and in the anterior cingulate in patients with schizophrenia suggesting that these changes are underlying pathophysiological processes of this disorder. Cannabis use may therefore be a moderating or causal factor contributing to grey matter alterations in schizophrenia and the development of psychotic symptoms.

Psychiatrists and other behavioral health professionals need to better understand the relationship between cannabis and mental disorders so that they can respond to increasing medical and recreational marijuana use among their patients. More than half of states now allow for medical use, and 8 states and the District of Columbia have legalized adult personal or recreational use. Knowledge about herbal cannabis, the endow cannabinoid system, and cannabinoid pharmacology is rapidly expanding. However, compared with the literature on non-medical cannabis use, the scientific literature on therapeutic use of cannabis is underdeveloped, as noted in a recent systematic review of medical cannabis and mental health. Although herbal cannabis has a long history of medicinal use, its federal prohibition under the Controlled Substances Act of 1970 with Drug Enforcement Administration Schedule I status has focused the federally supported cannabis research agenda for half a century on the potential harms rather than on the historically acknowledged therapeutic benefits of this complex plant.

The use of alcohol and drugs can negatively affect all aspects of a person’s life, impact their family, friends and community, and place an enormous burden on American society. One of the most significant areas of risk with the use of alcohol and drugs is the connection between alcohol, drugs and crime. Alcohol and drugs are implicated in an estimated 80% of offenses leading to incarceration in the United States such as domestic violence, driving while intoxicated, property offenses, drug offenses, and public-order offenses. Our nation’s prison population has exploded beyond capacity and most inmates are in prison, in large part, because of substance abuse:80% of offenders abuse drugs or alcohol. Nearly 50% of jail and prison inmates are clinically addicted. Approximately 60% of individuals arrested for most types of crimes test positive for illegal drugs at arrest.

Research has shown that marijuana’s negative effects on attention, memory, and learning can last for days or weeks after the acute effects of the drug wear off, depending on the person’s history with the drug.53Consequently, someone who smokes marijuana daily may be functioning at a reduced intellectual level most or all of the time. Considerable evidence suggests that students who smoke marijuana have poorer educational outcomes than their nonsmoking peers. For example, a review of relevant studies found marijuana use to be associated with reduced educational attainment (i.e., reduced chances of graduating).54 A recent analysis using data from three large studies in Australia and New Zealand found that adolescents who used marijuana regularly were significantly less likely than their non-using peers to finish high school or obtain a degree. They also had a much higher chance of developing dependence, using other drugs, and attempting suicide.55 Several studies have also linked heavy marijuana use to lower income, greater welfare dependence, unemployment, criminal behavior, and lower life satisfaction.

There are more than 60 systematic reviews and meta-analyses discussing the safety, toxicology, potency, and therapeutic potential of exogenous cannabinoids. However, the general consensus of these reports is largely mixed and inconclusive. The uncertainty surrounding safety and efficacy of exogenous cannabinoids is not a product of the lack of research, but rather a product of the extreme variability in study methodology and quality. This review provides a summary of the current research on the safety and efficacy of exogenous cannabinoids, including a brief description of the chemical constituents of cannabis and how it interacts with the endo cannabinoid system; a summary of what is known about the acute and long-term effects of cannabis; and a discussion of the therapeutic potential. Conclusions on safety and efficacy will then be compared with the current social and political climate in order to highlight the need for policy changes and general guidelines.

Cannabis is currently used as a therapeutic product throughout the world.

The following benefits of cannabis have been documented around the world by various medical and government bodies. Feeling of well-being, Increased sociability, Muscle relaxant, Analgesic effect, Appetite stimulation, Antiemetic effect, Anticonvulsant effect, Lower intraocular pressure In Canada, section 56 of the Controlled Drugs and Substances Act gives Health Canada the discretionary power to grant an exemption for medical reasons to persons who consider that the use of cannabis is beneficial to their health.

Hence, many sick people in Canada have obtained Health Canada approval to smoke cannabis for therapeutic reasons: however, it is still illegal to grow cannabis. Health Canada has awarded funds for clinical trials to assess the effectiveness of marijuana. Community Research Initiative of Toronto (CRIT): usefulness of cannabis among individuals with HIV/AIDS. McMaster University, Hamilton: usefulness of cannabis among patients with epilepsy. Multiple Sclerosis Clinic, Saskatoon: evaluation of the effects of cannabis on muscle spasticity among sufferers of multiple sclerosis and. G.F. Strong Rehabilitation Centre, Vancouver: evaluation of the effects of cannabis on spasticity of limbs among individuals with spinal cord injuries

Marijuana utilize can prompt the improvement of issue utilize, known as a marijuana use disorder, which appears as addiction in serious cases Marijuana use disorders are regularly associated with dependence—in which a person feels withdrawal symptoms when not taking the drug. Individuals who utilize marijuana every now and again frequently report crabbiness, state of mind and rest troubles, diminished hunger, yearnings, anxiety, and additionally different types of physical uneasiness that crest inside the primary a great many quitting and last up to 2 weeks.

Opioid use disorder is a restorative condition described by a tricky example of opioid utilizes that causes clinically huge weakness or misery. It frequently incorporates a powerful urge to utilize opioids, increased tolerance to opioids, and withdrawal syndrome when opioids are abruptly discontinued. . Opioid dependence can show as physical reliance, mental reliance, or both.

Like tobacco smoke, marijuana smoke is an irritant to the throat and lungs and can cause a heavy cough during use. It also contains levels of volatile chemicals and tar that are similar to tobacco smoke, raising concerns about risk for cancer and lung disease. Marijuana smoking is associated with large airway inflammation, increased airway resistance, and lung hyperinflation, and those who smoke marijuana regularly report more symptoms of chronic bronchitis than those who do not smoke. One study found that people who frequently smoke marijuana had more outpatient medical visits for respiratory problems than those who do not case studies have suggested that, because of THC’s immune-suppressing effects, smoking marijuana might increase susceptibility to lung infections, such as pneumonia, in people with immune deficiencies: however, a large AIDS cohort study did not confirm such an association. Animal and human studies have not found that marijuana increases risk for emphysema.

Neuroimaging has helped to elucidate that substance-use disorders are associated with changes in brain structure, function, and neurochemistry. Neuroimaging studies have improved our understanding of the neural correlates of addiction and how these relate to addictive behavior. Nevertheless, the potential impact of neuroimaging on treatment development for addictions has yet to be fully realized. Despite substantial advances, treatments are often not fully effective, and addiction continues to be a major public health burden . Neuroimaging has contributed to our appreciation of the complexity of addiction, highlighting the need for measurable indices, or biomarkers, of addiction to improve treatment outcomes. A “biomarker” typically refers to a measurable indicator of normal or abnormal biological processes or response to treatment . In substance-abuse research, biomarkers are needed to clarify how or why a treatment has an effect, on whom and under what circumstances.

Recent advances in neuroimaging are affording greater opportunities to identify brain biomarkers that might be used to improve outcomes of treatment for substance-use disorders. Neuroimaging is a critical tool in biomarker development because it relates neural circuits to both molecular mechanisms and behavior or clinical variation. In particular, neuroimaging studies are central to an emerging research effort to identify cross-diagnostic processes in substance-use and related disorders based on both behavior and neural circuits . In this work, alterations in brain activation patterns related to dimensions of functioning in individuals with addictions may be considered to represent abnormal processing associated with addictive behavior. Such research holds significant potential for identifying targets for treatment, detecting subgroups for treatment selection, and/or predicting treatment response . As disorder heterogeneity and individual variation pose significant challenges for delivering effective treatment, considering addictions in terms of dimensions of functioning may help to elucidate factors relevant to treatment response and lead to more specific, more effective treatments . This paper reviews neuroimaging research seeking to identify potential biomarkers of treatment response from several dimensions of functioning relevant to addiction:, impulsivity, and cognitive control.

Marijuana use disorders appear to be very similar to other substance use disorders, although the long-term clinical outcomes may be less severe. On average, adults seeking treatment for marijuana use disorders have used marijuana nearly every day for more than 10 years and have attempted to quit more than six times.117 People with marijuana use disorders, especially adolescents, often also suffer from other psychiatric disorders (comorbidity). They may also use or be addicted to other substances, such as cocaine or alcohol. Available studies indicate that effectively treating the mental health disorder with standard treatments involving

medications and behavioral therapies may help reduce marijuana use, particularly among those involved with heavy use and those with more chronic mental disorders. The following behavioral treatments have shown promise:

Cannabis research is challenging since the plant is illegal in most countries. Research-grade samples of the drug are difficult to obtain for research purposes, unless granted under authority of national governments.

There are also other difficulties in researching the effects of cannabis. Many people who smoke cannabis also smoke tobacco. This causes confounding factors, where questions arise as to whether the tobacco, the cannabis, or both that have caused a cancer. Another difficulty researchers have is in recruiting people who smoke cannabis into studies. Because cannabis is an illegal drug in many countries, people may be reluctant to take part in research, and if they do agree to take part, they may not say how much cannabis they actually smoke.

found that the use of high CBD-to-THC strains of cannabis showed significantly fewer positive symptoms such as delusions and hallucinations, better cognitive function and both lower risk for developing psychosis, as well as a later age of onset of the illness, compared to cannabis with low CBD-to-THC ratios. Cochrane found that research was insufficient to determine the safety and efficacy to using cannabis to treat schizophrenia or psychosis

January proved a volatile month for cannabis stocks across the sector, with U.S. Attorney General Jeff Sessions rescinding federal protections for state-level legalization and a crypto currency crash that led FOMO investors to rattle the marijuana markets. Still, despite mad money men and their cries of market speculation The North American Marijuana Index reported an 18 percent increase in January.

Sessions’ announcement sent the market into a slight panic in early January, but investors quickly bounced back as industry insiders took to the press to bring a sense of calm to their shareholders. Meanwhile, the opening of California’s adult-use market never really had a chance to take a foothold in the market, stymied by the Sessions’ announcement only four days into the new year. A quick bounce led to a rocky few weeks that many attributed to a pot stock correction.

The United States Marijuana Index followed this same pattern, gaining 13 percent on January 2, losing 21 percent following Sessions’ announcement, and climbing 11 percent again the following day. Wall Street had a relatively prosperous month, unaware of the storm to hit in February.

Meanwhile, the Canadian Marijuana Index rallied 22 percent in January as the country prepared for full adult-use legalization this summer - that market too, unaware at the time that those plans would later be impeded. Alcan Global Corporation (TSXV: ABCN), News trike Resources Ltd.(TSXV:HIP), and THC Biomed Intl Ltd. (CSE:THC) each gained more than 90 percent for the month. Misty at University of California, Irvine

Prior Cannabis Use Is Associated with Outcome after Intracerebral Hemorrhage:

An analysis of an international, multicenter, observational database of consecutive patients with spontaneous ICH was conducted. We extracted the following characteristics on presentation: demographics, risk factors, antiplatelet or anticoagulant use, Glasgow Coma Scale, ICH score, neuroimaging parameters, and urine toxicology screen (UTS) results. Modified Rankin Scale (MRS) score was utilized for determination of outcome at discharge. Adjusted logistic ordinal regression was used as shift analysis to assess the impact of cannabis use on MRS score at discharge. The adjusted common OR measured the likelihood that cannabis use would lead to lower MRS scores. Within a cohort of 725 spontaneous ICH patients, UTS was positive for cannabinoids in 8.6%. Cannabinoids-positive (CB+) patients were more frequently Caucasian (p < 0.001), younger (p < 0.001), and had lower median ICH scores on admission (p = 0.017) than those who were cannabinoids-negative. CB+ patients also showed a shift toward better outcome in the distribution of MRS categories, with an adjusted common OR of 0.544 (95% CI 0.330-0.895, p = 0.017).In this multinational cohort, cannabis use was discovered in nearly 10% of patients with spontaneous ICH. Although there was no relationship between cannabis use and specific ICH characteristics, CB+ patients had milder ICH presentation and less disability at discharge.

In preclinical animal studies, evidence links cannabis with hyperplasia, obesity, and insulin resistance. Epidemiologic data, however, suggest an inverse cannabis smoking-diabetes mellitus association. Here, we offer epidemiologic estimates from eight independent replications from (1) the National Health and Nutrition Examination Surveys, and (2) the National Surveys on Drug Use and Health (2005-2012).
For each national survey participant, computer-assisted self-interviews assess cannabis smoking and physician-diagnosed diabetes mellitus; the National Health and Nutrition Examination Surveys provide additional biomarker values and a composite diabetes diagnosis. Regression analyses produce estimates of cannabis smoking-diabetes associations. Meta-analyses summarize the replication estimates. Recently active cannabis smoking and diabetes mellitus are inversely associated. The meta-analytic summary odds ratio is 0.7 (95% confidence interval = 0.6, 0.8).Current evidence is too weak for causal inference, but there now is a more stable evidence base for new lines of clinical translational research on a possibly protective (or spurious) cannabis smoking-diabetes mellitus association suggested in prior research.

Special Reports, Substance Use Disorder

It is vital that physicians—particularly psychiatrists who are on the frontlines with patients who struggle with cannabis use—are able to identify and characterize cannabis use disorders; provide education; and offer effective, evidence-based treatments. This article provides a brief overview of each of these topics by walking through clinical decision-making with a case vignette that touches on common experiences in treating a patient with cannabis use disorder.

A separate and important issue is screening for emerging drugs of abuse, including synthetic “marijuana” products such as K2 and spice. Although these products are chemically distinct from the psychoactive compounds in the traditional cannabis plant, some cannabis users have tried synthetic “marijuana” products because of their gross physical similarity to cannabis plant matter.

About Conference

International Conference on cannabis, which is scheduled during November 15-16, 2018at Osaka, Japan. The main theme of the conference is “Challenges and Barriers in Agronomy, Medicinal & upshot of Cannabis " which covers wide range of critically important sessions. It’s a platform to bring all the cannabis scientists together to share their experiences. it’s the amalgam of scientific research as well as innovative ideas.

Addictive disorders, for example, substance abuse and dependence are regular issue that include the abuse of alcohol or drugs. Addiction creates after some time and is an incessant and backsliding ailment.
There are three different terms used to define substance-related addictive disorders:

Substance abuse, as a disorder, alludes to the mishandle of illicit substances or the abusive utilization of lawful substances. Liquor is the most well-known legitimate drug to be abused

Substance dependence is an addictive disorder that describes continued use of drugs or alcohol, even when significant problems related to their use have developed.

Chemical dependence is additionally an addictive disorder that portrays the urgent utilization of chemicals (typically drugs or alcohol) and the failure to quit utilizing them in spite of the considerable number of issues caused.

Meet and exchange knowledge with true pioneers from all over the world

Demonstrate your company’s leadership in the Cannabis field

Reach out to key leaders, academic and industry researchers and clinicians

Raise your company’s visibility in the field.

The main aim of the Conference is to bring the latest information and best practices on the introduction of medical cannabis into modern evidence-based medicine and to help to establish the use of medical cannabis as a standard medical procedure. To achieve its aim, the ​International Conference on Medical Cannabis is designed as an open forum for scientists and other experts, for practitioners in the field such as medical doctors, pharmacists, medical nurses and other paramedical staff, for patient activists, for decision makers and business persons, for the general public and, last but not least, for the media.

Benefits of attending:

A general overview of the state and scope of the cannabis industry today

Current hiring trends including which positions are currently in greatest demand

Gain an understanding of how these companies operate and prefer to be approached

How to stand out as a desirable candidate to a cannabis industry employer

An opportunity to have your questions answered

An option to upgrade to the conference floor, to take advantage of a complimentary resume review by Viridian Staffing as well as on-site career counseling in the Juana Career Lounge. If any of CCC’s exhibitors express they are hiring for a role you appear to be a likely fit for, Viridian will direct you accordingly.

Who should sponsor/exhibit:

Pharmaceuticals

Drug Manufacturers

Hospitals

Educational Institutes

Research Centers

Market Analysis:

Debate about medical marijuana is challenging the basic foundations of the accepted practice in the medical, legal and ethical communities. However, the purpose of this position statement paper has been to frame the debate, with the latest evidence-based researches and practice, and to support the treatment of medical conditions and alleviating symptoms by using the medical marijuana.

Proponents in the medical field argue for medical use of marijuana based on its effectiveness in managing debilitating diseases. The current another is supporting the use of medical marijuana cautiously and compassionately with patients who have debilitating symptoms and medical condition. In order to achieve that several recommendations were synthesized based on the reviewed literature

Importance and Scope:

Marijuana is the most commonly used illicit drug (22.2 million people have used it in the past month) according to the 2015 National Survey on Drug Use and Health.3 Its use is more prevalent among men than women—a gender gap that widened in the years 2007 to 2014

Marijuana use is widespread among adolescents and young adults. According to the Monitoring the Future survey —an annual survey of drug use and attitudes among the Nation’s middle and high school students—most measures of marijuana use by 8th, 10th, and 12th graders peaked in the mid-to-late 1990s and then began a period of gradual decline through the mid-2000s before levelling off. Most measures showed some decline again in the past 5 years.In 2016, 9.4 percent of 8th graders reported marijuana use in the past year and 5.4 percent in the past month (current use). Among 10th graders, 23.9 percent had used marijuana in the past year and 14.0 percent in the past month. Rates of use among 12th graders were higher still: 35.6 percent had used marijuana during the year prior to the survey and 22.5 percent used in the past month; 6.0 percent said they used marijuana daily or near-daily 5.

Medical emergencies possibly related to marijuana use have also increased. The Drug Abuse Warning Network (DAWN), a system for monitoring the health impact of drugs, estimated that in 2011, there were nearly 456,000 drug-related emergency department visits in the United States in which marijuana use was mentioned in the medical record (a 21 percent increase over 2009). About two-thirds of patients were male and 13 percent were between the ages of 12 and 17.6 It is unknown whether this increase is due to increased use, increased potency of marijuana (amount of THC it contains), or other factors. It should be noted, however, that mentions of marijuana in medical records do not necessarily indicate that these emergencies were directly related to marijuana intoxication.

There are many reasons to attend a cannabis related conference, we’re highlighting just a few to get started:

Learn and Prepare: A focus of many cannabis focused conferences is to help and prepare cannabis business for success in the industry. You will get to learn from experienced cannabis professionals in one place over a day or two. At many conferences there is going to be numerous sessions and table discussions where you will get to learn about the latest trends and technologies in the industry.

Connect: Meet and exchange knowledge with true pioneers from all over the world. Can you imagine how many people you’ll meet; mentors, peers, contacts, customers, and partners. Conferences are the perfect meet up.

Be inspired: A marijuana conference allows you to network with like-minded people who are going in the same direction. The conferences tend to bring together several leaders and pioneers in the industry. Going to a marijuana conference will help you to put your ‘eggs in a row,’ setting your priorities and goals so that you can benefit.

Share: You will also have various opportunities to talk about your company and ideas. Share your success stories and any hurdles you’ve had to jump over.

Some products manufactured by the industry related Neuroscience Research:

Printabowl

The grass is green for careers in cannabis research

Novus Acquisition & Development

Abattis Bioceuticals Corp

Ratan Tata, Rajan Anandan back cannabis research firm

WeedTraQR

PreciseCannabis

New Frontier

Gateway

About City:

Japan is prosperous organizations in the nation Furthermore need the mossy cup oak different economy for Asia. The welcome spring may be gentle also acquires out Japan’s acclaimed cherry blossoms. The middle of the year begins with the blustery season to late June alternately promptly July. Osaka castle will be Japanese manor in Japan. The palace will be a standout amongst Japan's practically celebrated point of interest Also it assumed a major part in the unification from claiming japan.

Osaka is a large port city and commercial center on the Japanese island of Honshu. It's known for its modern architecture, nightlife and hearty street food. The 16th-century shogunate Osaka Castle, which has undergone several restorations, is its main historical landmark. It's surrounded by a moat and park with plum, peach and cherry-blossom trees. Sumiyoshi-taisha is among Japan’s oldest Shinto shrines.

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