Anti-AURKA (YLILEYAPL) TCR, pSFG(TCR-L004)

The vector of anti-AURKA T cell receptor (TCR) is constructed for the engineering of T cell to target Human AURKA. The T cells are genetically modified through transduction with a retroviral vector expressing AURKA-specific T cell receptor. And the vector product was designed for the treatment of leukemia.

Details

Target

AURKA

Target Species

Human

Epitope

YLILEYAPL

Format

Non-modiﬁed TCR

HLA

HLA-A*0201

Targeting Diseases

Leukemia

Vector Name

pSFG

Vector Length

8200bp

Vector Type

retroviral vector

Antibody Host

Human

Target

The protein encoded by this gene is a cell cycle-regulated kinase that appears to be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation. The encoded protein is found at the centrosome in interphase cells and at the spindle poles in mitosis. This gene may play a role in tumor development and progression. A processed pseudogene of this gene has been found on chromosome 1, and an unprocessed pseudogene has been found on chromosome 10. Multiple transcript variants encoding the same protein have been found for this gene.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.