After the completion of her last two painted graphic novels in 2011,[4] she began focusing primarily on large scale gallery work done in oil.[7] Her gallery work focuses on the figure with the goal being a strong emotional connection to the audience.[7] She opened her first solo exhibition in September 2013 at the R. Michelson Gallery. Her pieces have since been shown and acquired by private collectors and several museums, including the Eric Carle Museum of Picture Book Art and the Museum of American Illustration at the Society of Illustrators in New York City.[7][8]

In a crossover between her gallery work and her work in illustration, one of her pieces, The Visitor, was chosen as the cover of Spectrum 21.[9]

After the release of Onslaught (2002), it was reported on Magic the Gathering news sites that Guay had been informed that the seven works she created for the set would be her last. In what the sites reported to be her own words: "the new art director, Jeremy Cranford, thinks my work is too feminine for the vision he has for the game."[10]

Amid fan outrage, Wizards of the Coast released a statement clarifying their position — that Guay was never fired, but simply not contracted as a freelance artist for Legions (2003), and that her work would be used in future sets:

"To clear up some of the confusion, Rebecca Guay was not fired by Wizards of the Coast; she is a freelance artist who works with us from time to time. In fact, Rebecca is currently working with WotC on other projects in our Dungeons and Dragons line. In the Legions set, the creative team had to think of a way to show what happened to Otaria after Kamahl destroyed the Mirari. We decided we would show the effect of this magic by making really intense exaggerated versions of all of the creatures. We would have 'super versions' and 'hyper versions' of Soldiers, Clerics, Wizards, Zombies, Goblins, Elves, etc. Even the land would evolve over the course of Onslaught block. When selecting artists, the creative team selected artists that we felt would fit precisely within this vision of what Otaria was becoming. Even though Rebecca was not selected for work in the Legions set, Rebecca continues to be a highly valued part of our art team. Rebecca and I have discussed this and I have assured her that her art will appear in future Magic expansions." - Jeremy Cranford|Ask Wizards[11]

Wizards of the Coast used Guay's work for at least seven Magic sets and a number of other products since then. One of the commissioned works, a tribute to the controversy, appeared in the 2004 joke set Unhinged:

"Persecute Artist" (1BB Sorcery - Choose an artist other than Rebecca Guay. Target player reveals his or her hand and discards all nonland cards by the chosen artist. The torches and pitchforks were no match for Rebecca's fans.)

A card satirizing Jeremy Cranford also appeared in Unhinged:

"Fascist Art Director" (1WW Creature — Human Horror - 2/2 WW: Fascist Art Director gains protection from the artist of your choice until end of turn. Dear Mr. and Mrs. Cranford, After careful analysis of Jeremy's vocational testing, I feel that he is best suited for a career in either torture or art direction.)[12]

In 2014 Guay launched a Kickstarter project collecting her artworks from 1993 to 2014, EVOLUTION. It was successfully funded by her fans in March of the same year (reaching over three times its intended goal of $36,000 at $124,057)[13] and arrived from publication in January, 2015.[14]