Browse our IRAK2 Proteins (IRAK2)

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Interleukin-1 Receptor-Associated Kinase 2 Proteins (IRAK2)

On www.antibodies-online.com are 11 Interleukin-1 Receptor-Associated Kinase 2 (IRAK2) Proteins from 6 different suppliers available. Additionally we are shipping IRAK2 Antibodies (207) and IRAK2 Kits (1) and many more products for this protein. A total of 232 IRAK2 products are currently listed.

This for the first time implicates human IRAK2 in a human disease and highlights the R214G IRAK2 variant as a potential novel and broadly applicable biomarker for disease or as a therapeutic intervention point.

Human miR (show MLXIP Proteins)-373 is silenced by histone modification in lung cancer cells and is a negative regulator of the mesenchymal phenotype through downstream IRAK2 and LAMP1 (show LAMP1 Proteins) target genes.

These findings demonstrate an unexpected linkage of the innate immunity machinery to unfolded protein response signaling, revealing IRAK2 as a novel amplifier of the IRE1 (show ERN1 Proteins) pathway.

Our results establish that the IRAK2-TRAF6 (show TRAF6 Proteins) interaction is rate limiting for the late, but not the early phase of cytokine production in bone marrow-derived macrophages and plasmacytoid dendritic cells

IRAK-2 mediates pathology in a CD4 T cell specific manner by promoting Th17 cell development through enhancement of IL-1beta-induced activation of transcription factors RORgammat and BATF.

the kinase activity of IRAK2 is required for the optimal activation of mitogen-activated protein kinase (show MAPK1 Proteins) signaling, which regulates cytokine and chemokine (show CCL1 Proteins) production at posttranscriptional levels.

Alternative splicing of the Irak2 gene in mice will generate agonistic or antagonistic Irak2 isoforms, which is likely to have consequences for the regulation of Toll (show TLR4 Proteins)-like receptors signaling.

These results reveal that IRAK2 is required for LPS (show TLR4 Proteins)-mediated post-transcriptional control of cytokine and chemokine (show CCL1 Proteins) expression, which plays an essential role in TLR4 (show TLR4 Proteins)-induced septic shock.

Data demonstrate that IRAK-2 is an essential component of the early TLR response in MOLF/Ei mice and show a distinct pathway of p38 (show CRK Proteins) and NF-kappaB (show NFKB1 Proteins) activation in this model organism.

IRAK2 Protein Profile

Protein Summary

IRAK2 encodes the interleukin-1 receptor-associated kinase 2, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. IRAK2 is reported to participate in the IL1-induced upregulation of NF-kappaB.