TY - THES
T1 - 3,4-Methylenedioxymethamphetamine (MDMA, "Ecstasy") : studies on MDMA metabolism and pharmacokinetics in humans and squirrel monkeys
A1 - Müller,Melanie
Y1 - 2009/07/09
N2 - In the presented studies, the pharmacokinetic profile and metabolic pattern of MDMA in different species were determined. Furthermore species-specific differences on conjugate cleavage of the phase II metabolites were investigated in human, squirrel monkey, and rat. After optimization of cleavage conditions respectively for each species, liquid chromatography-mass spectrometry (LC-MS)-based assay procedures were developed and focused on determination of the parent compound and its corresponding major metabolites in plasma of different species. After administration of different oral MDMA doses pharmacokinetics for MDMA and its metabolites (MDA, HHMA, and HMMA) were determined in squirrel monkey and human. In both species nonlinear pharmacokinetics were firmly established with nonlinear MDMA accumulation occurring at plasma MDMA levels that develop in humans after typical doses. Comparison of pharmacokinetics of MDMA and its metabolites between humans and squirrel monkeys revealed the squirrel monkey as appropriate model for predicting outcomes of MDMA exposure in humans depending upon the pharmacokinetic parameter of MDMA or its metabolites that mostly influences the outcome of interest.
KW - Metabolismus
KW - Ecstasy
KW - Pharmakokinetik
CY - Saarbrücken
PB - Saarländische Universitäts- und Landesbibliothek
AD - Postfach 151141, 66041 Saarbrücken
UR - http://scidok.sulb.uni-saarland.de/volltexte/2009/2285
ER -