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{\*\bkmkstart filing_1}{\*\bkmkend filing_1}{\*\bkmkstart doc_1_1}{\*\bkmkend doc_1_1}\par\pard\plain\ul{\field{\*\fldinst HYPERLINK \\l "toc_11558912" }{\*\fldrslt\cf3\f52\fs16\b\ql Table of Contents}}\par\pard\plain\cf1\f51\fs20\b\qr Filed Pursuant to Rule 424(b)(5)
\par\pard\plain\fs16\pard\plain\cf1\f51\fs20\b\qr Registration No. 333-202960\par\pard\plain\cf1\f51\fs16\ql \~\par\pard\plain\cf1\f51\fs20\b\ql PROSPECTUS SUPPLEMENT\par\pard\plain\cf1\f51\fs20\ql (To Prospectus dated August\~19, 2015)\par\pard\plain\cf1\f51\fs24\ql \~\par\qc{\*\shppict{\pict\pngblip\picw307\pich66\picscalex75\picscaley75\bliptag-1081281392
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\par\pard\plain\sb264\cf1\f51\fs28\b\qc $18,000,000\par\pard\plain\cf1\f51\fs28\b\qc Common Stock\par\pard\plain\cf1\f51\fs24\ql \~\par\pard\plain\brdrb\brdrs\sa44\cf1\f51\fs20\qc \~\par\pard\plain\sb264\fi462\cf1\f51\fs20\ql We have entered into a sales agreement, or the sales agreement, with H.C. Wainwright\~& Co., LLC, or Wainwright, relating\plain\cf1\f51\fs20\ql to shares of our common stock, $0.001 par value per share, offered by this prospectus supplement and the accompanying\plain\cf1\f51\fs20\ql prospectus. In accordance with the terms of the sales agreement, we may offer and sell shares of our common stock having an\plain\cf1\f51\fs20\ql aggregate offering price of not more than $18,000,000.\par\pard\plain\sb264\fi462\cf1\f51\fs20\ql Our common stock is listed on NASDAQ Capital Market under the symbol \u8220?SVRA.\u8221? The last reported sale\plain\cf1\f51\fs20\ql price of our common stock on April\~28, 2017 was $8.76 per share.\par\pard\plain\sb264\fi462\cf1\f51\fs20\ql Upon our delivery of a placement notice and subject to the terms and conditions of the sales agreement, Wainwright may\plain\cf1\f51\fs20\ql sell shares of our common stock by methods deemed to be an \u8220?at the market offering\u8221? as defined in Rule\~415\plain\cf1\f51\fs20\ql promulgated under the Securities Act of 1933, as amended, or the Securities Act. Wainwright will act as sales agent using its\plain\cf1\f51\fs20\ql commercially reasonable efforts consistent with its normal trading and sales practices, on mutually agreed terms between\plain\cf1\f51\fs20\ql Wainwright and us. There is no arrangement for funds to be received in any escrow, trust or similar arrangement.\par\pard\plain\sb264\fi462\cf1\f51\fs20\ql Wainwright will be entitled to compensation at a fixed commission rate of 3% of the gross proceeds of each sale of shares\plain\cf1\f51\fs20\ql of our common stock. In connection with the sale of our shares of common stock on our behalf, Wainwright may be deemed to\plain\cf1\f51\fs20\ql be an \u8220?underwriter\u8221? within the meaning of the Securities Act and the compensation of Wainwright may be deemed\plain\cf1\f51\fs20\ql to be underwriting commissions or discounts. We have also agreed to provide indemnification and contribution to Wainwright\plain\cf1\f51\fs20\ql with respect to certain liabilities, including liabilities under the Securities Act.\par\pard\plain\cf1\f51\fs24\ql \~\par\pard\plain\brdrb\brdrs\sa44\cf1\f51\fs20\qc \~\par\pard\plain\sb264\fi594\cf1\f51\fs24\b\ql Investing in our securities involves a high degree of risk. See \u8220?\pard\plain\sb264\ul{\field{\*\fldinst HYPERLINK \\l "supprom357361_4_11558912" }{\*\fldrslt\cf3\f51\fs24\b\ql Risk Factors}}\plain\cf1\f51\fs24\b\ql ,\u8221? beginning on page S-5 of this prospectus supplement, as well as the documents\plain\cf1\f51\fs24\b\ql incorporated by reference in this prospectus supplement, for a discussion of the factors you should\plain\cf1\f51\fs24\b\ql carefully consider before deciding to purchase our securities.\par\pard\plain\sb264\fi462\cf1\f51\fs20\b\ql Neither the Securities and Exchange Commission nor any state securities commission has approved or disapproved of\plain\cf1\f51\fs20\b\ql these securities or determined if this prospectus supplement or the accompanying prospectus is truthful or complete. Any\plain\cf1\f51\fs20\b\ql representation to the contrary is a criminal offense.\par\pard\plain\cf1\f51\fs24\ql \~\par\pard\plain\brdrb\brdrs\sa44\cf1\f51\fs20\qc \~\par\pard\plain\sb264\cf1\f51\fs36\b\qc H.C. Wainwright\~& Co.\par\pard\plain\sb264\cf1\f51\fs20\b\qc The date of this prospectus supplement is May\~1, 2017
\page\par\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par\par\pard\plain\ul{\field{\*\fldinst HYPERLINK \\l "toc_11558912" }{\*\fldrslt\cf3\f52\fs16\b\ql Table of Contents}}{\*\bkmkstart toc_11558912}{\*\bkmkend toc_11558912}\par\pard\plain\cf1\f51\fs20\b\qc TABLE OF CONTENTS\par\pard\plain\sb264\cf1\f51\fs20\b\qc Prospectus Supplement\par\pard\plain\cf1\f51\fs24\ql \~
\par\pard\plain
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\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
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{\trowd\clvertalb\cellx9859\clvertalb\cellx10071\clvertalb\cellx10245\clvertalb\cellx10709\clvertalb\cellx10800\trrh248
\pard\plain\intbl\li176\ul{\field{\*\fldinst HYPERLINK \\l "supprom357361_6_11558912" }{\*\fldrslt\cf3\f51\fs20\ql USE OF PROCEEDS}}\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr S-7\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell{
{\trowd\clvertalb\cellx9859\clvertalb\cellx10071\clvertalb\cellx10245\clvertalb\cellx10709\clvertalb\cellx10800\trrh248\row}}}
{\trowd\clvertalc\cellx9859\clvertalc\cellx10799\trrh66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx9859\clvertalc\cellx10799\trrh66\row}}}
{\trowd\clvertalb\cellx9859\clvertalb\cellx10071\clvertalb\cellx10245\clvertalb\cellx10709\clvertalb\cellx10800\trrh248
\pard\plain\intbl\li176\ul{\field{\*\fldinst HYPERLINK \\l "supprom357361_7_11558912" }{\*\fldrslt\cf3\f51\fs20\ql DILUTION}}\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr S-7\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell{
{\trowd\clvertalb\cellx9859\clvertalb\cellx10071\clvertalb\cellx10245\clvertalb\cellx10709\clvertalb\cellx10800\trrh248\row}}}
{\trowd\clvertalc\cellx9859\clvertalc\cellx10799\trrh66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx9859\clvertalc\cellx10799\trrh66\row}}}
{\trowd\clvertalb\cellx9859\clvertalb\cellx10071\clvertalb\cellx10245\clvertalb\cellx10709\clvertalb\cellx10800\trrh248
\pard\plain\intbl\li176\ul{\field{\*\fldinst HYPERLINK \\l "supprom357361_8_11558912" }{\*\fldrslt\cf3\f51\fs20\ql PLAN OF DISTRIBUTION}}\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr S-8\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell{
{\trowd\clvertalb\cellx9859\clvertalb\cellx10071\clvertalb\cellx10245\clvertalb\cellx10709\clvertalb\cellx10800\trrh248\row}}}
{\trowd\clvertalc\cellx9859\clvertalc\cellx10799\trrh66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx9859\clvertalc\cellx10799\trrh66\row}}}
{\trowd\clvertalb\cellx9859\clvertalb\cellx10071\clvertalb\cellx10245\clvertalb\cellx10709\clvertalb\cellx10800\trrh248
\pard\plain\intbl\li176\ul{\field{\*\fldinst HYPERLINK \\l "supprom357361_9_11558912" }{\*\fldrslt\cf3\f51\fs20\ql LEGAL MATTERS}}\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr S-9\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell{
{\trowd\clvertalb\cellx9859\clvertalb\cellx10071\clvertalb\cellx10245\clvertalb\cellx10709\clvertalb\cellx10800\trrh248\row}}}
{\trowd\clvertalc\cellx9859\clvertalc\cellx10799\trrh66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx9859\clvertalc\cellx10799\trrh66\row}}}
{\trowd\clvertalb\cellx9859\clvertalb\cellx10071\clvertalb\cellx10245\clvertalb\cellx10709\clvertalb\cellx10800\trrh248
\pard\plain\intbl\li176\ul{\field{\*\fldinst HYPERLINK \\l "supprom357361_10_11558912" }{\*\fldrslt\cf3\f51\fs20\ql EXPERTS}}\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr S-9\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell{
{\trowd\clvertalb\cellx9859\clvertalb\cellx10071\clvertalb\cellx10245\clvertalb\cellx10709\clvertalb\cellx10800\trrh248\row}}}
{\trowd\clvertalc\cellx9859\clvertalc\cellx10799\trrh66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx9859\clvertalc\cellx10799\trrh66\row}}}
{\trowd\clvertalb\cellx9859\clvertalb\cellx10071\clvertalb\cellx10245\clvertalb\cellx10709\clvertalb\cellx10800\trrh248
\pard\plain\intbl\li176\ul{\field{\*\fldinst HYPERLINK \\l "supprom357361_11_11558912" }{\*\fldrslt\cf3\f51\fs20\ql WHERE YOU CAN FIND ADDITIONAL INFORMATION}}\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr S-10\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell{
{\trowd\clvertalb\cellx9859\clvertalb\cellx10071\clvertalb\cellx10245\clvertalb\cellx10709\clvertalb\cellx10800\trrh248\row}}}
{\trowd\clvertalc\cellx9859\clvertalc\cellx10799\trrh66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx9859\clvertalc\cellx10799\trrh66\row}}}
{\trowd\clvertalb\cellx9859\clvertalb\cellx10071\clvertalb\cellx10245\clvertalb\cellx10709\clvertalb\cellx10800\trrh248
\pard\plain\intbl\li176\ul{\field{\*\fldinst HYPERLINK \\l "supprom357361_12_11558912" }{\*\fldrslt\cf3\f51\fs20\ql INCORPORATION OF CERTAIN INFORMATION BY REFERENCE}}\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr S-10\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell{
{\trowd\clvertalb\cellx9859\clvertalb\cellx10071\clvertalb\cellx10245\clvertalb\cellx10709\clvertalb\cellx10800\trrh248\row}}}
{\trowd\clvertalc\cellx9859\clvertalc\cellx10799\trrh66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx9859\clvertalc\cellx10799\trrh66\row}}}
{\trowd\cellx9859\clvertalb\cellx10071\clvertalb\cellx10245\clvertalb\cellx10709\clvertalb\cellx10800\trrh248
\pard\plain\intbl\li176\ul{\field{\*\fldinst HYPERLINK \\l "toc357361_1_11558912" }{\*\fldrslt\cf3\f51\fs20\ql ABOUT THIS PROSPECTUS}}\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr ii\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell{
{\trowd\cellx9859\clvertalb\cellx10071\clvertalb\cellx10245\clvertalb\cellx10709\clvertalb\cellx10800\trrh248\row}}}
{\trowd\clvertalc\cellx9859\clvertalc\cellx10799\trrh66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx9859\clvertalc\cellx10799\trrh66\row}}}
{\trowd\cellx9859\clvertalb\cellx10071\clvertalb\cellx10245\clvertalb\cellx10709\clvertalb\cellx10800\trrh248
\pard\plain\intbl\li176\ul{\field{\*\fldinst HYPERLINK \\l "toc357361_2_11558912" }{\*\fldrslt\cf3\f51\fs20\ql SUMMARY}}\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 1\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell{
{\trowd\cellx9859\clvertalb\cellx10071\clvertalb\cellx10245\clvertalb\cellx10709\clvertalb\cellx10800\trrh248\row}}}
{\trowd\clvertalc\cellx9859\clvertalc\cellx10799\trrh66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx9859\clvertalc\cellx10799\trrh66\row}}}
{\trowd\cellx9859\clvertalb\cellx10071\clvertalb\cellx10245\clvertalb\cellx10709\clvertalb\cellx10800\trrh248
\pard\plain\intbl\li176\ul{\field{\*\fldinst HYPERLINK \\l "toc357361_3_11558912" }{\*\fldrslt\cf3\f51\fs20\ql RISK FACTORS}}\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 5\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell{
{\trowd\cellx9859\clvertalb\cellx10071\clvertalb\cellx10245\clvertalb\cellx10709\clvertalb\cellx10800\trrh248\row}}}
{\trowd\clvertalc\cellx9859\clvertalc\cellx10799\trrh66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx9859\clvertalc\cellx10799\trrh66\row}}}
{\trowd\cellx9859\clvertalb\cellx10071\clvertalb\cellx10245\clvertalb\cellx10709\clvertalb\cellx10800\trrh248
\pard\plain\intbl\li176\ul{\field{\*\fldinst HYPERLINK \\l "toc357361_4_11558912" }{\*\fldrslt\cf3\f51\fs20\ql SPECIAL NOTE REGARDING FORWARD-LOOKING STATEMENTS}}\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 5\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell{
{\trowd\cellx9859\clvertalb\cellx10071\clvertalb\cellx10245\clvertalb\cellx10709\clvertalb\cellx10800\trrh248\row}}}
{\trowd\clvertalc\cellx9859\clvertalc\cellx10799\trrh66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx9859\clvertalc\cellx10799\trrh66\row}}}
{\trowd\cellx9859\clvertalb\cellx10071\clvertalb\cellx10245\clvertalb\cellx10709\clvertalb\cellx10800\trrh248
\pard\plain\intbl\li176\ul{\field{\*\fldinst HYPERLINK \\l "toc357361_5_11558912" }{\*\fldrslt\cf3\f51\fs20\ql USE OF PROCEEDS}}\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 6\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell{
{\trowd\cellx9859\clvertalb\cellx10071\clvertalb\cellx10245\clvertalb\cellx10709\clvertalb\cellx10800\trrh248\row}}}
{\trowd\clvertalc\cellx9859\clvertalc\cellx10799\trrh66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx9859\clvertalc\cellx10799\trrh66\row}}}
{\trowd\cellx9859\clvertalb\cellx10071\clvertalb\cellx10245\clvertalb\cellx10709\clvertalb\cellx10800\trrh248
\pard\plain\intbl\li176\ul{\field{\*\fldinst HYPERLINK \\l "toc357361_6_11558912" }{\*\fldrslt\cf3\f51\fs20\ql SECURITIES WE MAY OFFER}}\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 6\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell{
{\trowd\cellx9859\clvertalb\cellx10071\clvertalb\cellx10245\clvertalb\cellx10709\clvertalb\cellx10800\trrh248\row}}}
{\trowd\clvertalc\cellx9859\clvertalc\cellx10799\trrh66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx9859\clvertalc\cellx10799\trrh66\row}}}
{\trowd\cellx9859\clvertalb\cellx10071\clvertalb\cellx10245\clvertalb\cellx10709\clvertalb\cellx10800\trrh248
\pard\plain\intbl\li176\ul{\field{\*\fldinst HYPERLINK \\l "toc357361_7_11558912" }{\*\fldrslt\cf3\f51\fs20\ql DESCRIPTION OF COMMON STOCK AND PREFERRED STOCK}}\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 6\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell{
{\trowd\cellx9859\clvertalb\cellx10071\clvertalb\cellx10245\clvertalb\cellx10709\clvertalb\cellx10800\trrh248\row}}}
{\trowd\clvertalc\cellx9859\clvertalc\cellx10799\trrh66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx9859\clvertalc\cellx10799\trrh66\row}}}
{\trowd\cellx9859\clvertalb\cellx10071\clvertalb\cellx10245\clvertalb\cellx10709\clvertalb\cellx10800\trrh248
\pard\plain\intbl\li176\ul{\field{\*\fldinst HYPERLINK \\l "toc357361_8_11558912" }{\*\fldrslt\cf3\f51\fs20\ql DESCRIPTION OF DEBT SECURITIES}}\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 10\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell{
{\trowd\cellx9859\clvertalb\cellx10071\clvertalb\cellx10245\clvertalb\cellx10709\clvertalb\cellx10800\trrh248\row}}}
{\trowd\clvertalc\cellx9859\clvertalc\cellx10799\trrh66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx9859\clvertalc\cellx10799\trrh66\row}}}
{\trowd\cellx9859\clvertalb\cellx10071\clvertalb\cellx10245\clvertalb\cellx10709\clvertalb\cellx10800\trrh248
\pard\plain\intbl\li176\ul{\field{\*\fldinst HYPERLINK \\l "toc357361_9_11558912" }{\*\fldrslt\cf3\f51\fs20\ql DESCRIPTION OF WARRANTS}}\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 18\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell{
{\trowd\cellx9859\clvertalb\cellx10071\clvertalb\cellx10245\clvertalb\cellx10709\clvertalb\cellx10800\trrh248\row}}}
{\trowd\clvertalc\cellx9859\clvertalc\cellx10799\trrh66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx9859\clvertalc\cellx10799\trrh66\row}}}
{\trowd\cellx9859\clvertalb\cellx10071\clvertalb\cellx10245\clvertalb\cellx10709\clvertalb\cellx10800\trrh248
\pard\plain\intbl\li176\ul{\field{\*\fldinst HYPERLINK \\l "toc357361_10_11558912" }{\*\fldrslt\cf3\f51\fs20\ql DESCRIPTION OF UNITS}}\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 20\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell{
{\trowd\cellx9859\clvertalb\cellx10071\clvertalb\cellx10245\clvertalb\cellx10709\clvertalb\cellx10800\trrh248\row}}}
{\trowd\clvertalc\cellx9859\clvertalc\cellx10799\trrh66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx9859\clvertalc\cellx10799\trrh66\row}}}
{\trowd\cellx9859\clvertalb\cellx10071\clvertalb\cellx10245\clvertalb\cellx10709\clvertalb\cellx10800\trrh248
\pard\plain\intbl\li176\ul{\field{\*\fldinst HYPERLINK \\l "toc357361_11_11558912" }{\*\fldrslt\cf3\f51\fs20\ql LEGAL OWNERSHIP OF SECURITIES}}\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 21\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell{
{\trowd\cellx9859\clvertalb\cellx10071\clvertalb\cellx10245\clvertalb\cellx10709\clvertalb\cellx10800\trrh248\row}}}
{\trowd\clvertalc\cellx9859\clvertalc\cellx10799\trrh66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx9859\clvertalc\cellx10799\trrh66\row}}}
{\trowd\cellx9859\clvertalb\cellx10071\clvertalb\cellx10245\clvertalb\cellx10709\clvertalb\cellx10800\trrh248
\pard\plain\intbl\li176\ul{\field{\*\fldinst HYPERLINK \\l "toc357361_12_11558912" }{\*\fldrslt\cf3\f51\fs20\ql PLAN OF DISTRIBUTION}}\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 24\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell{
{\trowd\cellx9859\clvertalb\cellx10071\clvertalb\cellx10245\clvertalb\cellx10709\clvertalb\cellx10800\trrh248\row}}}
{\trowd\clvertalc\cellx9859\clvertalc\cellx10799\trrh66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx9859\clvertalc\cellx10799\trrh66\row}}}
{\trowd\cellx9859\clvertalb\cellx10071\clvertalb\cellx10245\clvertalb\cellx10709\clvertalb\cellx10800\trrh248
\pard\plain\intbl\li176\ul{\field{\*\fldinst HYPERLINK \\l "toc357361_13_11558912" }{\*\fldrslt\cf3\f51\fs20\ql LEGAL MATTERS}}\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 26\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell{
{\trowd\cellx9859\clvertalb\cellx10071\clvertalb\cellx10245\clvertalb\cellx10709\clvertalb\cellx10800\trrh248\row}}}
{\trowd\clvertalc\cellx9859\clvertalc\cellx10799\trrh66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx9859\clvertalc\cellx10799\trrh66\row}}}
{\trowd\cellx9859\clvertalb\cellx10071\clvertalb\cellx10245\clvertalb\cellx10709\clvertalb\cellx10800\trrh248
\pard\plain\intbl\li176\ul{\field{\*\fldinst HYPERLINK \\l "toc357361_14_11558912" }{\*\fldrslt\cf3\f51\fs20\ql EXPERTS}}\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 26\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell{
{\trowd\cellx9859\clvertalb\cellx10071\clvertalb\cellx10245\clvertalb\cellx10709\clvertalb\cellx10800\trrh248\row}}}
{\trowd\clvertalc\cellx9859\clvertalc\cellx10799\trrh66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx9859\clvertalc\cellx10799\trrh66\row}}}
{\trowd\cellx9859\clvertalb\cellx10071\clvertalb\cellx10245\clvertalb\cellx10709\clvertalb\cellx10800\trrh248
\pard\plain\intbl\li176\ul{\field{\*\fldinst HYPERLINK \\l "toc357361_15_11558912" }{\*\fldrslt\cf3\f51\fs20\ql INFORMATION INCORPORATED BY REFERENCE}}\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 26\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell{
{\trowd\cellx9859\clvertalb\cellx10071\clvertalb\cellx10245\clvertalb\cellx10709\clvertalb\cellx10800\trrh248\row}}}
{\trowd\clvertalc\cellx9859\clvertalc\cellx10799\trrh66
\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\clvertalc\cellx9859\clvertalc\cellx10799\trrh66\row}}}
{\trowd\cellx9859\clvertalb\cellx10071\clvertalb\cellx10245\clvertalb\cellx10709\clvertalb\cellx10800\trrh248
\pard\plain\intbl\li176\ul{\field{\*\fldinst HYPERLINK \\l "toc357361_16_11558912" }{\*\fldrslt\cf3\f51\fs20\ql WHERE YOU CAN FIND MORE INFORMATION}}\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 27\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell{
{\trowd\cellx9859\clvertalb\cellx10071\clvertalb\cellx10245\clvertalb\cellx10709\clvertalb\cellx10800\trrh248\row}}}\pard\plain\cf1\f51\fs16\ql \~\par\pard\plain\cf1\f51\fs20\qc S-i
\page\par\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par\par\pard\plain\ul{\field{\*\fldinst HYPERLINK \\l "toc_11558912" }{\*\fldrslt\cf3\f52\fs16\b\ql Table of Contents}}{\*\bkmkstart supprom357361_1_11558912}{\*\bkmkend supprom357361_1_11558912}\par\pard\plain\cf1\f51\fs20\b\qc ABOUT THIS PROSPECTUS SUPPLEMENT\par\pard\plain\sb264\fi462\cf1\f51\fs20\ql This document is in two parts. The first part is the prospectus supplement, including the documents incorporated by\plain\cf1\f51\fs20\ql reference, which describes the specific terms of this offering. The second part, the accompanying prospectus, including the\plain\cf1\f51\fs20\ql documents incorporated by reference, provides more general information. Before you invest, you should carefully read this\plain\cf1\f51\fs20\ql prospectus supplement, the accompanying prospectus, all information incorporated by reference herein and therein, as well as the\plain\cf1\f51\fs20\ql additional information described under \u8220?Where You Can Find Additional Information\u8221? on page S-10 of this\plain\cf1\f51\fs20\ql prospectus supplement. These documents contain information you should consider when making your investment decision. This\plain\cf1\f51\fs20\ql prospectus supplement may add, update or change information contained in the accompanying prospectus. To the extent there is a\plain\cf1\f51\fs20\ql conflict between the information contained in this prospectus supplement, on the one hand, and the information contained in the\plain\cf1\f51\fs20\ql accompanying prospectus or any document incorporated by reference therein filed prior to the date of this prospectus supplement,\plain\cf1\f51\fs20\ql on the other hand, you should rely on the information in this prospectus supplement. If any statement in one of these documents\plain\cf1\f51\fs20\ql is inconsistent with a statement in another document having a later date \u8212? for example, a document filed after the date of\plain\cf1\f51\fs20\ql this prospectus supplement and incorporated by reference in this prospectus supplement and the accompanying prospectus\plain\cf1\f51\fs20\ql \u8212? the statement in the document having the later date modifies or supersedes the earlier statement.\par\pard\plain\sb264\fi462\cf1\f51\fs20\ql You should rely only on the information contained or incorporated by reference in this prospectus supplement, the\plain\cf1\f51\fs20\ql accompanying prospectus and in any free writing prospectuses we may provide to you in connection with this offering. We have\plain\cf1\f51\fs20\ql not, and Wainwright has not, authorized any other person to provide you with any information that is different. If anyone\plain\cf1\f51\fs20\ql provides you with different or inconsistent information, you should not rely on it. We are offering to sell, and seeking offers to\plain\cf1\f51\fs20\ql buy, shares of our common stock only in jurisdictions where offers and sales are permitted. The distribution of this prospectus\plain\cf1\f51\fs20\ql supplement and the offering of the common stock in certain jurisdictions may be restricted by law. Persons outside the United\plain\cf1\f51\fs20\ql States who come into possession of this prospectus supplement must inform themselves about, and observe any restrictions\plain\cf1\f51\fs20\ql relating to, the offering of the common stock and the distribution of this prospectus supplement outside the United States. This\plain\cf1\f51\fs20\ql prospectus supplement does not constitute, and may not be used in connection with, an offer to sell, or a solicitation of an offer\plain\cf1\f51\fs20\ql to buy, any securities offered by this prospectus supplement by any person in any jurisdiction in which it is unlawful for such\plain\cf1\f51\fs20\ql person to make such an offer or solicitation.\par\pard\plain\sb264\fi462\cf1\f51\fs20\ql We further note that the representations, warranties and covenants made by us in any agreement that is filed as an exhibit to\plain\cf1\f51\fs20\ql any document that is incorporated by reference in the accompanying prospectus were made solely for the benefit of the parties to\plain\cf1\f51\fs20\ql such agreement, including, in some cases, for the purpose of allocating risk among the parties to such agreements, and should not\plain\cf1\f51\fs20\ql be deemed to be a representation, warranty or covenant to you. Moreover, such representations, warranties or covenants were\plain\cf1\f51\fs20\ql accurate only as of the date when made. Accordingly, such representations, warranties and covenants should not be relied on as\plain\cf1\f51\fs20\ql accurately representing the current state of our affairs.\par\pard\plain\cf1\f51\fs16\ql \~\par\pard\plain\cf1\f51\fs20\qc S-1
\page\par\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par\par\pard\plain\ul{\field{\*\fldinst HYPERLINK \\l "toc_11558912" }{\*\fldrslt\cf3\f52\fs16\b\ql Table of Contents}}{\*\bkmkstart supprom357361_2_11558912}{\*\bkmkend supprom357361_2_11558912}\par\pard\plain\li22\ri-22\cf1\f51\fs20\b\qc PROSPECTUS SUPPLEMENT SUMMARY\par\pard\plain\li22\ri-22\sb264\fi440\cf1\f51\fs20\i\ql This summary highlights selected information about us, this offering and information appearing elsewhere in this\plain\li22\ri-22\cf1\f51\fs20\i\ql prospectus supplement and in the documents we incorporate by reference. This summary is not complete and does not\plain\li22\ri-22\cf1\f51\fs20\i\ql contain all the information you should consider before investing in our common stock pursuant to this prospectus\plain\li22\ri-22\cf1\f51\fs20\i\ql supplement and the accompanying prospectus. Before making an investment decision, to fully understand this offering and\plain\li22\ri-22\cf1\f51\fs20\i\ql its consequences to you, you should carefully read this entire prospectus supplement and the accompanying prospectus,\plain\li22\ri-22\cf1\f51\fs20\i\ql including \u8220?Risk Factors\u8221? beginning on page S-5 of this prospectus supplement and the financial statements\plain\li22\ri-22\cf1\f51\fs20\i\ql and related notes and the other information that we incorporated by reference herein, including our Annual Reports on\plain\li22\ri-22\cf1\f51\fs20\i\ql Form 10-K and Quarterly Reports on Form 10-Q that we file from time to time.\par\pard\plain\li22\ri-22\sb264\fi440\cf1\f51\fs20\i\ql Unless the context otherwise requires, all references in this prospectus to \u8220?Savara,\u8221? \u8220?we,\u8221?\plain\li22\ri-22\cf1\f51\fs20\i\ql \u8220?us,\u8221? \u8220?our,\u8221? \u8220?the Company\u8221? or similar words refer to Savara Inc., together with\plain\li22\ri-22\cf1\f51\fs20\i\ql our consolidated subsidiaries.\par\pard\plain\li22\ri-22\sb396\cf1\f51\fs20\b\ql Overview\par\pard\plain\li22\ri-22\sb132\fi440\cf1\f51\fs20\ql We are a clinical-stage specialty pharmaceutical company focused on the development and commercialization of\plain\li22\ri-22\cf1\f51\fs20\ql novel therapies for the treatment of serious or life-threatening rare respiratory diseases. Our pipeline comprises AeroVanc,\plain\li22\ri-22\cf1\f51\fs20\ql a Phase 3 ready inhaled vancomycin, Molgradex, a Phase 2/3 stage inhaled granulocyte-macrophage colony-stimulating\plain\li22\ri-22\cf1\f51\fs20\ql factor, or\~GM-CSF and Aironite, an inhaled nebulized sodium nitrate solution to treat HFpEF.\~Our strategy involves\plain\li22\ri-22\cf1\f51\fs20\ql expanding our pipeline of\~best-in-class\~products through indication expansion, strategic development partnerships and\plain\li22\ri-22\cf1\f51\fs20\ql product acquisitions, with the goal of becoming a leading company in our field. Our management team has significant\plain\li22\ri-22\cf1\f51\fs20\ql experience in orphan drug development and pulmonary medicine, in identifying unmet needs, creating and acquiring new\plain\li22\ri-22\cf1\f51\fs20\ql product candidates, and effectively advancing them to approvals and commercialization.\par\pard\plain\li22\ri-22\sb264\fi440\cf1\f51\fs20\ql AeroVanc, an inhaled formulation of vancomycin, is being developed for the treatment of persistent\plain\li22\ri-22\cf1\f51\fs20\ql methicillin-resistant\~\plain\li22\ri-22\cf1\f51\fs20\i\ql Staphylococcus aureus\plain\li22\ri-22\cf1\f51\fs20\ql , or MRSA, lung infection in cystic fibrosis, or CF, patients. CF is a genetic\plain\li22\ri-22\cf1\f51\fs20\ql disease that involves sticky mucus buildup in the lungs, persistent lung infections and permanent and progressive\plain\li22\ri-22\cf1\f51\fs20\ql respiratory disability. There are approximately 30,000 patients affected by CF in the United States, and MRSA infection\plain\li22\ri-22\cf1\f51\fs20\ql has become increasingly common in these patients, with a prevalence of approximately 26%. Persistent MRSA infection in\plain\li22\ri-22\cf1\f51\fs20\ql CF patients is associated with increased use of intravenous, or IV, antibiotics, increased hospitalizations, a faster decline of\plain\li22\ri-22\cf1\f51\fs20\ql lung function, as well as shortened life-expectancy. Due to the lung pathology associated with CF, persistent MRSA lung\plain\li22\ri-22\cf1\f51\fs20\ql infection is difficult to eradicate or manage using oral or IV antibiotics, and there is no standard of care to manage this\plain\li22\ri-22\cf1\f51\fs20\ql condition. Whereas inhaled antibiotics have become a cornerstone of treating the most prevalent chronic pathogen in CF\plain\li22\ri-22\cf1\f51\fs20\ql patients,\~\plain\li22\ri-22\cf1\f51\fs20\i\ql Pseudomonas aeruginosa\plain\li22\ri-22\cf1\f51\fs20\ql , there are no approved inhaled antibiotics addressing MRSA lung infection. In a\plain\li22\ri-22\cf1\f51\fs20\ql randomized, double-blind, placebo-controlled Phase 2 study in CF patients with persistent MRSA infection, AeroVanc met\plain\li22\ri-22\cf1\f51\fs20\ql a primary endpoint to reduce MRSA density in sputum, and showed encouraging trends of improvement in lung function,\plain\li22\ri-22\cf1\f51\fs20\ql and respiratory symptoms, as well as prolongation of the time to use of other antibiotics, with best responses in subjects\plain\li22\ri-22\cf1\f51\fs20\ql under 21 years of age. After receiving detailed guidance from the FDA, we have planned a pivotal Phase 3 study of\plain\li22\ri-22\cf1\f51\fs20\ql AeroVanc that we anticipate starting in the third quarter of 2017.\par\pard\plain\li22\ri-22\sb264\fi440\cf1\f51\fs20\ql Molgradex, an inhaled formulation of recombinant human\~GM-CSF,\~is being developed for the treatment of\plain\li22\ri-22\cf1\f51\fs20\ql autoimmune pulmonary alveolar proteinosis, or PAP, a rare lung disease characterized by the\~build-up\~of lung surfactant in\plain\li22\ri-22\cf1\f51\fs20\ql the alveoli, or air sacs, of the lungs. PAP is estimated to have a prevalence of approximately 2,500 patients in the United\plain\li22\ri-22\cf1\f51\fs20\ql States. The disease process underlying PAP involves an autoimmune response against a naturally occurring\plain\li22\ri-22\cf1\f51\fs20\ql protein,\~GM-CSF,\~suppressing the stimulating activity of\~GM-CSF\~on lung macrophages which function to clear excess\plain\li22\ri-22\cf1\f51\fs20\ql surfactant from the alveoli. The best treatment currently available for PAP is a procedure called whole lung lavage, or\plain\li22\ri-22\cf1\f51\fs20\ql WLL, which entails washing out the lungs bronchoscopically with saline,\par\pard\plain\li22\ri-22\cf1\f51\fs16\ql \~
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\par\pard\plain\fs16\par\pard\plain\brdrb\brdrs\cf1\f51\fs16\ql \~\par\pard\plain\cf1\f51\fs20\qc S-2
\page\par\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par\par\pard\plain\ul{\field{\*\fldinst HYPERLINK \\l "toc_11558912" }{\*\fldrslt\cf3\f52\fs16\b\ql Table of Contents}}\par\pard\plain\li22\ri-22\cf1\f51\fs20\ql segment by segment, under general anesthesia. By its nature, WLL is an invasive and inconvenient procedure that requires\plain\li22\ri-22\cf1\f51\fs20\ql hospitalization, and highly experienced physicians at specialist sites. Based on published investigator-sponsored treatment\plain\li22\ri-22\cf1\f51\fs20\ql experience with inhaled\~GM-CSF,\~we believe Molgradex has the potential to replace the inactivated\~GM-CSF\~in PAP\plain\li22\ri-22\cf1\f51\fs20\ql patients, and thereby to restore the surfactant clearing activity of the alveolar macrophages, and to become the treatment of\plain\li22\ri-22\cf1\f51\fs20\ql choice for PAP. We have completed a Phase 1 study in healthy volunteers, and are currently conducting a pivotal Phase\plain\li22\ri-22\cf1\f51\fs20\ql 2/3 study in Europe and Japan, with top line results expected in the first quarter of 2018.\par\pard\plain\li22\ri-22\sb264\fi440\cf1\f51\fs20\ql AIR001, a sodium nitrite solution for inhalation via nebulization, is in Phase 2 clinical development for the treatment\plain\li22\ri-22\cf1\f51\fs20\ql of heart failure with preserved ejection fraction, or HFpEF, also known as diastolic heart failure or heart failure with\plain\li22\ri-22\cf1\f51\fs20\ql preserved systolic function. Data show there are approximately 5.7\~million individuals with heart failure in the U.S. and\plain\li22\ri-22\cf1\f51\fs20\ql that approximately 50% of patients hospitalized for heart failure have HFpEF.\~Enrollment is ongoing in three\plain\li22\ri-22\cf1\f51\fs20\ql investigator-sponsored Phase 2 studies of AIR001 in patients with HFpEF being conducted at prestigious research\plain\li22\ri-22\cf1\f51\fs20\ql institutions. Positive interim results from one of those studies were published in November 2016. Additionally, positive\plain\li22\ri-22\cf1\f51\fs20\ql results from a completed Phase 2 study of AIR001 in patients with HFpEF were published in July 2016.\~We anticipate\plain\li22\ri-22\cf1\f51\fs20\ql results from one of the ongoing studies, a multicenter, randomized, double-blind, placebo-controlled crossover Phase 2\plain\li22\ri-22\cf1\f51\fs20\ql study of AIR001 in HFpEF being conducted by the Heart Failure Clinical Research Network (known as the HFN) in the\plain\li22\ri-22\cf1\f51\fs20\ql first quarter of 2018.\par\pard\plain\li22\ri-22\sb396\cf1\f51\fs20\b\ql Recent Developments; Corporate Information\par\pard\plain\li22\ri-22\sb132\fi440\cf1\f51\fs20\ql On April\~27, 2017, Savara completed its merger with Mast Therapeutics, Inc. (\u8220?Mast\u8221?) in accordance\plain\li22\ri-22\cf1\f51\fs20\ql with the terms of the Agreement and Plan of Merger and Reorganization, dated as of January\~6, 2017 (the \u8220?Merger\plain\li22\ri-22\cf1\f51\fs20\ql Agreement\u8221?). Under the Merger Agreement, Victoria Merger Corp., a wholly owned subsidiary of Mast, merged\plain\li22\ri-22\cf1\f51\fs20\ql with and into Savara, with Savara surviving as a wholly owned subsidiary of Mast. Pursuant to the terms and subject to the\plain\li22\ri-22\cf1\f51\fs20\ql conditions set forth in the Merger Agreement, Savara stockholders became the majority stockholders of the surviving\plain\li22\ri-22\cf1\f51\fs20\ql company and Mast changed its name to Savara Inc. Prior to the Mast merger, Savara acquired the assets of\plain\li22\ri-22\cf1\f51\fs20\ql Copenhagen-based Serendex Pharmaceuticals A/S (\u8220?Serendex\u8221?) on July\~15, 2016. Serendex was established in\plain\li22\ri-22\cf1\f51\fs20\ql 2008 and listed on the Oslo Stock Exchange in 2014. Serendex operated as a public company until their delisting on\plain\li22\ri-22\cf1\f51\fs20\ql May\~4, 2016, ahead of its acquisition by Savara.\par\pard\plain\li22\ri-22\sb264\fi440\cf1\f51\fs20\ql Our principal executive offices are located at 900 S. Capital of Texas Highway, Las Cimas IV, Suite 150. Austin,\plain\li22\ri-22\cf1\f51\fs20\ql Texas 78746 and our telephone number at that address is (512)\~961-1891. Our corporate website is located at\plain\li22\ri-22\cf1\f51\fs20\ql www.savarapharma.com. We make available free of charge through our website our annual report on Form 10-K, quarterly\plain\li22\ri-22\cf1\f51\fs20\ql reports on Form 10-Q, current reports on Form 8-K, and amendments to those reports filed or furnished pursuant to\plain\li22\ri-22\cf1\f51\fs20\ql Section\~13(a) or 15(d) of the Securities Exchange Act of 1934, as amended, or the Exchange Act, as soon as reasonably\plain\li22\ri-22\cf1\f51\fs20\ql practicable after we electronically file such material with, or furnish it to, the Securities Exchange Commission, or SEC.\plain\li22\ri-22\cf1\f51\fs20\ql The information contained in, or that can be accessed through, our website is not part of this prospectus supplement.\par\pard\plain\li22\ri-22\cf1\f51\fs16\ql \~
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\par\pard\plain\fs16\par\pard\plain\brdrb\brdrs\cf1\f51\fs16\ql \~\par\pard\plain\cf1\f51\fs20\qc S-3
\page\par\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par\par\pard\plain\ul{\field{\*\fldinst HYPERLINK \\l "toc_11558912" }{\*\fldrslt\cf3\f52\fs16\b\ql Table of Contents}}{\*\bkmkstart supprom357361_3_11558912}{\*\bkmkend supprom357361_3_11558912}\par\pard\plain\li22\ri-22\cf1\f51\fs20\b\qc THE OFFERING\par\pard\plain\li22\ri-22\cf1\f51\fs24\ql \~
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\pard\plain\intbl\li44\sa22\cf1\f51\fs20\ql Issuer\cell\pard\plain\intbl\cf1\f51\fs20\ql Savara Inc.\cell{
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\pard\plain\intbl\li44\sa22\cf1\f51\fs20\ql Common stock offered by us\cell\pard\plain\intbl\cf1\f51\fs20\ql Shares having an aggregate offering price of not more than $18,000,000.\cell{
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\pard\plain\intbl\li44\sa22\cf1\f51\fs20\ql Manner of offering\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8220?At the market offering\u8221? that may be made from time to time\plain\intbl\cf1\f51\fs20\ql through our sales agent, H.C. Wainwright & Co., LLC. See \u8220?Plan of\plain\intbl\cf1\f51\fs20\ql Distribution\u8221? on page S-8.\cell{
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\pard\plain\intbl\li44\sa22\cf1\f51\fs20\ql Use of proceeds\cell\pard\plain\intbl\cf1\f51\fs20\ql We intend to use the net proceeds for working capital and general corporate\plain\intbl\cf1\f51\fs20\ql purposes, which include, but are not limited to, the funding of clinical\plain\intbl\cf1\f51\fs20\ql development of and pursuing regulatory approval for our product\plain\intbl\cf1\f51\fs20\ql candidates, and general and administrative expenses. Please see \u8220?Use\plain\intbl\cf1\f51\fs20\ql of Proceeds\u8221? on page S-7.\cell{
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\pard\plain\intbl\li44\sa22\cf1\f51\fs20\ql Risk factors\cell\pard\plain\intbl\cf1\f51\fs20\ql This investment involves a high degree of risk. See \u8220?Risk\plain\intbl\cf1\f51\fs20\ql Factors\u8221? beginning on page S-5 of this prospectus supplement, as\plain\intbl\cf1\f51\fs20\ql well as the other information included in or incorporated by reference in\plain\intbl\cf1\f51\fs20\ql this prospectus supplement and the accompanying prospectus, for a\plain\intbl\cf1\f51\fs20\ql discussion of risks you should carefully consider before investing in our\plain\intbl\cf1\f51\fs20\ql securities.\cell{
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\pard\plain\intbl\li44\sa22\cf1\f51\fs20\ql NASDAQ Capital Market symbol\cell\pard\plain\intbl\cf1\f51\fs20\ql SVRA\cell{
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\par\pard\plain\fs16\par\pard\plain\brdrb\brdrs\cf1\f51\fs16\ql \~\par\pard\plain\cf1\f51\fs20\qc S-4
\page\par\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par\par\pard\plain\ul{\field{\*\fldinst HYPERLINK \\l "toc_11558912" }{\*\fldrslt\cf3\f52\fs16\b\ql Table of Contents}}{\*\bkmkstart supprom357361_4_11558912}{\*\bkmkend supprom357361_4_11558912}\par\pard\plain\cf1\f51\fs20\b\qc RISK FACTORS\par\pard\plain\sb264\fi462\cf1\f51\fs20\i\ql Investing in our securities involves a high degree of risk and uncertainty. In addition to the other information included or\plain\cf1\f51\fs20\i\ql incorporated by reference in this prospectus supplement and the accompanying prospectus, you should carefully consider the\plain\cf1\f51\fs20\i\ql risks described below, before making an investment decision with respect to the securities. We expect to update these Risk\plain\cf1\f51\fs20\i\ql Factors from time to time in the periodic and current reports that we file with the SEC after the date of this prospectus\plain\cf1\f51\fs20\i\ql supplement. These updated Risk Factors will be incorporated by reference in this prospectus supplement and the accompanying\plain\cf1\f51\fs20\i\ql prospectus. Please refer to these subsequent reports for additional information relating to the risks associated with investing in\plain\cf1\f51\fs20\i\ql our common stock. If any of such risks and uncertainties actually occurs, our business, financial condition, and results of\plain\cf1\f51\fs20\i\ql operations could be severely harmed. This could cause the trading price of our common stock to decline, and you could lose all\plain\cf1\f51\fs20\i\ql or part of your investment.\par\pard\plain\sb396\cf1\f51\fs20\b\ql Risks Related to this Offering\par\pard\plain\sb132\cf1\f51\fs20\b\i\ql Resales of our common stock in the public market by our stockholders during this offering may cause the market price of our\plain\cf1\f51\fs20\b\i\ql common stock to fall.\par\pard\plain\sb132\fi462\cf1\f51\fs20\ql We may issue common stock from time to time in connection with this offering. The issuance from time to time of these\plain\cf1\f51\fs20\ql new shares of our common stock, or our ability to issue new shares of common stock in this offering, could result in resales of\plain\cf1\f51\fs20\ql our common stock by our current stockholders concerned about the potential ownership dilution of their holdings. In turn, these\plain\cf1\f51\fs20\ql resales could have the effect of depressing the market price for our common stock.\par\pard\plain\sb264\cf1\f51\fs20\b\i\ql There may be future sales or other dilution of our equity, which may adversely affect the market price of our common stock.\par\pard\plain\sb264\fi462\cf1\f51\fs20\ql We are generally not restricted from issuing additional common stock, including any securities that are convertible into or\plain\cf1\f51\fs20\ql exchangeable for, or that represent the right to receive, common stock. The market price of our common stock could decline as a\plain\cf1\f51\fs20\ql result of sales of common stock or securities that are convertible into or exchangeable for, or that represent the right to receive,\plain\cf1\f51\fs20\ql common stock after this offering or the perception that such sales could occur.\par\pard\plain\sb264\cf1\f51\fs20\b\i\ql Our management will have broad discretion over the use of the net proceeds from this offering, you may not agree with how\plain\cf1\f51\fs20\b\i\ql we use the proceeds and the proceeds may not be invested successfully.\par\pard\plain\sb264\fi462\cf1\f51\fs20\ql We have not designated any portion of the net proceeds from this offering to be used for any particular purpose.\plain\cf1\f51\fs20\ql Accordingly, our management will have broad discretion as to the use of the net proceeds from this offering and could use them\plain\cf1\f51\fs20\ql for purposes other than those contemplated at the time of commencement of this offering. Accordingly, you will be relying on\plain\cf1\f51\fs20\ql the judgment of our management with regard to the use of these net proceeds, and you will not have the opportunity, as part of\plain\cf1\f51\fs20\ql your investment decision, to assess whether the proceeds are being used appropriately. It is possible that, pending their use, we\plain\cf1\f51\fs20\ql may invest the net proceeds in a way that does not yield a favorable, or any, return for our company.\par\pard\plain\sb264\cf1\f51\fs20\b\i\ql You may experience immediate and substantial dilution in the book value per share of the common stock you purchase.\par\pard\plain\sb264\fi462\cf1\f51\fs20\ql Because the prices per share at which shares of our common stock are sold in this offering may be substantially higher than\plain\cf1\f51\fs20\ql the book value per share of our common stock, you may suffer immediate and substantial dilution in the net tangible book value\plain\cf1\f51\fs20\ql of the common stock you purchase in this offering. The shares sold in this offering, if any, will be sold from time to time at\plain\cf1\f51\fs20\ql various prices. After giving effect to the sale of our common stock in the maximum aggregate offering amount of $18,000,000 at\plain\cf1\f51\fs20\ql an assumed offering price of\par\pard\plain\cf1\f51\fs16\ql \~\par\pard\plain\cf1\f51\fs20\qc S-5
\page\par\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par\par\pard\plain\ul{\field{\*\fldinst HYPERLINK \\l "toc_11558912" }{\*\fldrslt\cf3\f52\fs16\b\ql Table of Contents}}\par\pard\plain\cf1\f51\fs20\ql $8.76\~per share, the last reported sale price of our common stock on the NASDAQ Capital Market on April\~28, 2017 and after\plain\cf1\f51\fs20\ql deducting estimated offering commissions and expenses payable by us, our net tangible book value as of December\~31, 2016\plain\cf1\f51\fs20\ql would have been approximately $4.3 million, or $1.17 per share of common stock. This represents an immediate increase in the\plain\cf1\f51\fs20\ql net tangible book value of $2.62 per share to our existing stockholders and an immediate and substantial dilution in as-adjusted\plain\cf1\f51\fs20\ql net tangible book value of $4.97 per share to new investors who purchase our common stock in the offering. See\plain\cf1\f51\fs20\ql \u8220?Dilution\u8221? for a more detailed discussion of the dilution you may incur in connection with this offering.{\*\bkmkstart supprom357361_5_11558912}{\*\bkmkend supprom357361_5_11558912}\par\pard\plain\sb528\cf1\f51\fs20\b\qc SPECIAL NOTE REGARDING FORWARD-LOOKING STATEMENTS\par\pard\plain\sb264\fi462\cf1\f51\fs20\ql This prospectus supplement and our SEC filings that are incorporated by reference into this prospectus supplement contain\plain\cf1\f51\fs20\ql or incorporate by reference forward-looking statements within the meaning of Section\~27A of the Securities Act and Section\~21E\plain\cf1\f51\fs20\ql of the Exchange Act. All statements, other than statements of historical fact, included or incorporated by reference in this\plain\cf1\f51\fs20\ql prospectus supplement regarding our development of our products, financial position, strategy, regulatory status, clinical and\plain\cf1\f51\fs20\ql nonclinical studies, collaborations, commercial prospects, internal growth, competition, intellectual property, regulatory reforms,\plain\cf1\f51\fs20\ql products, objectives of management, and compliance with NASDAQ Capital Market listing standards are forward-looking\plain\cf1\f51\fs20\ql statements. Forward-looking statements may include, but are not limited to, statements about:\par\pard\plain\cf1\f51\fs12\ql \~
\par\pard\plain
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql the expected benefits of and potential value created by the merger between Mast and Savara;\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248\row}}}\pard\plain\cf1\f51\fs12\ql \~
\par\pard\plain
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql any statements of the plans, strategies and objectives of management for future operations;\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248\row}}}\pard\plain\cf1\f51\fs12\ql \~
\par\pard\plain
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql any statements concerning proposed new products, services or developments;\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248\row}}}\pard\plain\cf1\f51\fs12\ql \~
\par\pard\plain
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql any statements regarding future economic conditions or performance\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248\row}}}\pard\plain\cf1\f51\fs12\ql \~
\par\pard\plain
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh495
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql our ability to protect our intellectual property and operate our business without infringing upon the intellectual\plain\intbl\cf1\f51\fs20\ql property rights of others;\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh495\row}}}\pard\plain\cf1\f51\fs12\ql \~
\par\pard\plain
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql our estimates regarding the sufficiency of our cash resources and our need for additional funding; and\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248\row}}}\pard\plain\cf1\f51\fs12\ql \~
\par\pard\plain
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql our intended use of the net proceeds from offerings of our securities under this prospectus supplement.\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248\row}}}\pard\plain\sb264\fi462\cf1\f51\fs20\ql The words \u8220?believe,\u8221? \u8220?anticipate,\u8221? \u8220?estimate,\u8221? \u8220?plan,\u8221?\plain\cf1\f51\fs20\ql \u8220?expect,\u8221? \u8220?intend,\u8221? \u8220?may,\u8221? \u8220?could,\u8221? \u8220?should,\u8221?\plain\cf1\f51\fs20\ql \u8220?potential,\u8221? \u8220?likely,\u8221? \u8220?projects,\u8221? \u8220?continue,\u8221? \u8220?will,\u8221? and\plain\cf1\f51\fs20\ql \u8220?would\u8221? and similar expressions are intended to identify forward-looking statements, although not all\plain\cf1\f51\fs20\ql forward-looking statements contain these identifying words. Forward-looking statements reflect our current views with respect to\plain\cf1\f51\fs20\ql future events, are based on assumptions and are subject to risks and uncertainties. We cannot guarantee that we actually will\plain\cf1\f51\fs20\ql achieve the plans, intentions or expectations expressed in our forward-looking statements and you should not place undue\plain\cf1\f51\fs20\ql reliance on these statements. There are a number of important factors that could cause our actual results to differ materially from\plain\cf1\f51\fs20\ql those indicated or implied by forward-looking statements. These important factors include those discussed under the heading\plain\cf1\f51\fs20\ql \u8220?Risk Factors\u8221? contained or incorporated in this prospectus supplement and the accompanying prospectus and any\plain\cf1\f51\fs20\ql free writing prospectus we may authorize for use in connection with a specific offering. These factors and the other cautionary\plain\cf1\f51\fs20\ql statements made in this prospectus supplement and the accompanying prospectus should be read as being applicable to all related\plain\cf1\f51\fs20\ql forward-looking statements whenever they appear in this prospectus supplement and the accompanying prospectus. Except as\plain\cf1\f51\fs20\ql required by law, we do not assume any obligation to update any forward-looking statement. We disclaim any intention or\plain\cf1\f51\fs20\ql obligation to update or revise any forward-looking statement, whether as a result of new information, future events or otherwise.\par\pard\plain\cf1\f51\fs16\ql \~\par\pard\plain\cf1\f51\fs20\qc S-6
\page\par\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par\par\pard\plain\ul{\field{\*\fldinst HYPERLINK \\l "toc_11558912" }{\*\fldrslt\cf3\f52\fs16\b\ql Table of Contents}}{\*\bkmkstart supprom357361_6_11558912}{\*\bkmkend supprom357361_6_11558912}\par\pard\plain\cf1\f51\fs20\b\qc USE OF PROCEEDS\par\pard\plain\sb264\fi462\cf1\f51\fs20\ql We will have broad discretion in the use of the net proceeds from any sale of securities offered under this prospectus\plain\cf1\f51\fs20\ql supplement. We intend to use the net proceeds for working capital and general corporate purposes, which include, but are not\plain\cf1\f51\fs20\ql limited to, the funding of clinical development of and pursuing regulatory approval for our product candidates, and general and\plain\cf1\f51\fs20\ql administrative expenses.\par\pard\plain\sb264\fi462\cf1\f51\fs20\ql We have not determined the amount of net proceeds to be used specifically for such purposes. Pending the use of any net\plain\cf1\f51\fs20\ql proceeds, we expect to invest the net proceeds in interest-bearing, marketable securities.{\*\bkmkstart supprom357361_7_11558912}{\*\bkmkend supprom357361_7_11558912}\par\pard\plain\sb528\cf1\f51\fs20\b\qc DILUTION\par\pard\plain\sb264\fi462\cf1\f51\fs20\ql If you invest in our common stock, your interest will be diluted immediately to the extent of the difference between the\plain\cf1\f51\fs20\ql public offering price per share and the adjusted net tangible book value per share of our common stock after this offering.\par\pard\plain\sb264\fi462\cf1\f51\fs20\ql The net tangible book value of our common stock as of December\~31, 2016, was approximately $4.3\~million, or\plain\cf1\f51\fs20\ql approximately $1.17 per share, after giving effect to the reverse stock split of 70 to 1 that was effective on April\~27, 2017. Net\plain\cf1\f51\fs20\ql tangible book value per share represents the amount of our total tangible assets, excluding goodwill and intangible assets, less\plain\cf1\f51\fs20\ql total liabilities, divided by the total number of shares of our common stock outstanding. Dilution per share to new investors\plain\cf1\f51\fs20\ql represents the difference between the amount per\~share paid by purchasers for each share of common stock in this offering and\plain\cf1\f51\fs20\ql the net tangible book value per\~share of our common stock immediately following the completion of this offering.\par\pard\plain\sb264\fi462\cf1\f51\fs20\ql After giving effect to the sale of shares of our common stock in the aggregate amount of $18,000,000 at an assumed\plain\cf1\f51\fs20\ql offering price of $8.76 per share, the last reported sale price of our common stock on April\~28, 2017 on the NASDAQ Capital\plain\cf1\f51\fs20\ql Market, and after deducting estimated commissions and estimated offering expenses, our as-adjusted net tangible book value as\plain\cf1\f51\fs20\ql of December\~31, 2016 would have been approximately $21.6 million or approximately $3.79 per share. This represents an\plain\cf1\f51\fs20\ql immediate increase in net tangible book value of approximately $2.62 per share to our existing stockholders and an immediate\plain\cf1\f51\fs20\ql dilution in as-adjusted net tangible book value of approximately $4.97 per share to purchasers of our common stock in this\plain\cf1\f51\fs20\ql offering, as illustrated by the following table:\par\pard\plain\cf1\f51\fs24\ql \~
\par\pard\plain
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\pard\plain\intbl\li176\fi-176\cf1\f51\fs20\ql Assumed offering price per share\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\~\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr 8.76\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell{
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\pard\plain\intbl\li374\fi-176\cf1\f51\fs20\ql Net tangible book value per share as of December\~31, 2016\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\~\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr 1.17\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
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\pard\plain\intbl\li374\fi-176\cf1\f51\fs20\ql Increase per share attributable to this offering\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\~\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr 2.62\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{
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\pard\plain\intbl\li176\fi-176\cf1\f51\fs20\ql As-adjusted net tangible book value per share as of December\~31, 2016, after giving\plain\intbl\li176\cf1\f51\fs20\ql effect to this offering\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\~\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr 3.79\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell{
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\pard\plain\intbl\li176\fi-176\cf1\f51\fs20\ql Dilution per share to new investors participating in this offering\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\~\cell\pard\plain\intbl\cf1\f51\fs20\ql $\cell\pard\plain\intbl\cf1\f51\fs20\qr 4.97\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell{
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\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\cf1\f51\fs1\ql \~\~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\cf1\f51\fs1\ql \~\~\cell\pard\plain\intbl\cf1\f51\fs1\ql \~\cell\pard\plain\intbl\cf1\f51\fs1\ql \~\cell\pard\plain\intbl\cf1\f51\fs1\ql \~\cell{
{\trowd\trqc\clvertalb\cellx7047\clvertalb\cellx7479\clvertalb\cellx7599\clvertalb\cellx7969\clvertalb\cellx8059\clvertalb\cellx8491\clvertalb\cellx8611\clvertalb\cellx8981\clvertalc\cellx9072\trrh80\row}}}\pard\plain\sb264\fi462\cf1\f51\fs20\ql The table above assumes, for illustrative purposes only, an aggregate of 2,054,795 shares of our common stock are sold at a\plain\cf1\f51\fs20\ql price of $8.76 per share, for aggregate gross proceeds of $18,000,000. The shares, if any, sold in this offering will be sold from\plain\cf1\f51\fs20\ql time to time at various prices. An increase of $0.88 per share in the price at which the shares are sold from the assumed offering\plain\cf1\f51\fs20\ql price of $8.76 per share shown in the table above, assuming all of our common stock in the aggregate amount of $18,000,000 is\plain\cf1\f51\fs20\ql sold at that price, would increase our adjusted net tangible book value per share after the offering to $3.91 per share and increase\plain\cf1\f51\fs20\ql the dilution in net tangible book value per share to new investors in this offering to $5.72 per share, after deducting commissions\plain\cf1\f51\fs20\ql and estimated aggregate offering expenses payable by us. A decrease of $0.88 per share in the price at which the shares are sold\plain\cf1\f51\fs20\ql from the assumed offering price of $8.76 per share shown in the table above, assuming all of our common stock in the aggregate\plain\cf1\f51\fs20\ql amount of $18,000,000 is sold at that price, would decrease the adjusted net\par\pard\plain\cf1\f51\fs16\ql \~\par\pard\plain\cf1\f51\fs20\qc S-7
\page\par\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par\par\pard\plain\ul{\field{\*\fldinst HYPERLINK \\l "toc_11558912" }{\*\fldrslt\cf3\f52\fs16\b\ql Table of Contents}}\par\pard\plain\cf1\f51\fs20\ql tangible book value per share after the offering to $3.64 per share and decrease the dilution in net tangible book value per share\plain\cf1\f51\fs20\ql to new investors in this offering to $4.24 per share, after deducting commissions and estimated aggregate offering expenses\plain\cf1\f51\fs20\ql payable by us. This information is supplied for illustrative purposes only.\par\pard\plain\sb264\fi462\cf1\f51\fs20\ql The table above is based on 3,639,241 shares of our common stock outstanding as of December\~31, 2016, after giving effect\plain\cf1\f51\fs20\ql to the reverse stock split of 70 to 1 that was effective on April\~27, 2017 and excludes the following shares which have also been\plain\cf1\f51\fs20\ql updated for the reverse stock split:\par\pard\plain\cf1\f51\fs12\ql \~
\par\pard\plain
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh495
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql 1,152,231 shares of our common stock issuable upon exercise of warrants outstanding as of December\~31, 2016,\plain\intbl\cf1\f51\fs20\ql with a weighted-average exercise price of $41.03 per share;\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh495\row}}}\pard\plain\cf1\f51\fs12\ql \~
\par\pard\plain
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh495
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql 315,203 shares of our common stock issuable upon exercise of options outstanding as of December\~31, 2016,\plain\intbl\cf1\f51\fs20\ql with a weighted-average exercise price of $46.38 per share; and\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh495\row}}}\pard\plain\cf1\f51\fs12\ql \~
\par\pard\plain
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh495
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql 320,040 shares of our common stock available for future grants under our 2015 Omnibus Incentive Plan as of\plain\intbl\cf1\f51\fs20\ql December\~31, 2016.\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh495\row}}}\pard\plain\sb264\fi462\cf1\f51\fs20\ql To the extent that after December\~31, 2016 any outstanding options or warrants were or are exercised, new equity awards\plain\cf1\f51\fs20\ql were or are issued under our equity incentive plan, or we otherwise issued or issue additional shares of common stock in the\plain\cf1\f51\fs20\ql future at prices per share below the price per share for any shares sold in this offering, there will be further dilution to new\plain\cf1\f51\fs20\ql investors.{\*\bkmkstart supprom357361_8_11558912}{\*\bkmkend supprom357361_8_11558912}\par\pard\plain\sb528\cf1\f51\fs20\b\qc PLAN OF DISTRIBUTION\par\pard\plain\sb264\fi462\cf1\f51\fs20\ql We have entered into a sales agreement with H.C. Wainwright\~& Co., LLC, or Wainwright, under which we may issue and\plain\cf1\f51\fs20\ql sell from time to time shares of our common stock having an aggregate offering price of not more than $18,000,000 through\plain\cf1\f51\fs20\ql Wainwright as our sales agent. Sales of the common stock, if any, will be made by any method permitted by law deemed to be\plain\cf1\f51\fs20\ql an \u8220?at the market offering\u8221? as defined in Rule 415 promulgated under the Securities Act. Wainwright will offer our\plain\cf1\f51\fs20\ql common stock at prevailing market prices subject to the terms and conditions of the sales agreement as agreed upon by us and\plain\cf1\f51\fs20\ql Wainwright. We will designate the number of shares which we desire to sell, the time period during which sales are requested to\plain\cf1\f51\fs20\ql be made, any limitation on the number of shares that may be sold in one day and any minimum price below which sales may not\plain\cf1\f51\fs20\ql be made. Subject to the terms and conditions of the sales agreement, Wainwright will use its commercially reasonable efforts to\plain\cf1\f51\fs20\ql sell on our behalf all of the shares of common stock requested to be sold by us. We or Wainwright may suspend the offering of\plain\cf1\f51\fs20\ql the common stock being made through Wainwright under the sales agreement upon proper notice to the other party.\par\pard\plain\sb264\fi462\cf1\f51\fs20\ql Wainwright will provide written confirmation to us following the close of trading on the NASDAQ Capital Market as\plain\cf1\f51\fs20\ql applicable, each day in which common stock is sold through it as sales agent under the sales agreement. Each confirmation will\plain\cf1\f51\fs20\ql include the number of shares of common stock sold through it as sales agent on that day, the gross sales price per share, the net\plain\cf1\f51\fs20\ql proceeds to us and the compensation payable by us to Wainwright.\par\pard\plain\sb264\fi462\cf1\f51\fs20\ql Settlement for sales of common stock will occur on the third business day or such shorter settlement cycle as may be in\plain\cf1\f51\fs20\ql effect under Exchange Act Rule 15c6-1 from time to time, following the date on which any sales are made, or on some other\plain\cf1\f51\fs20\ql date that is agreed upon by us and Wainwright in connection with a particular transaction, in return for payment of the net\plain\cf1\f51\fs20\ql proceeds to us. There is no arrangement for funds to be received in an escrow, trust or similar arrangement.\par\pard\plain\sb264\fi462\cf1\f51\fs20\ql We will pay Wainwright in cash, upon each sale of our shares of common stock pursuant to the sales agreement, a\plain\cf1\f51\fs20\ql commission equal to 3.0% of the gross proceeds from each sale of shares of our common stock. Wainwright may effect sales to\plain\cf1\f51\fs20\ql or through dealers, and such dealers may receive compensation in the form of discounts, concessions or commissions from\plain\cf1\f51\fs20\ql Wainwright and/or purchasers of shares of common stock for whom\par\pard\plain\cf1\f51\fs16\ql \~\par\pard\plain\cf1\f51\fs20\qc S-8
\page\par\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par\par\pard\plain\ul{\field{\*\fldinst HYPERLINK \\l "toc_11558912" }{\*\fldrslt\cf3\f52\fs16\b\ql Table of Contents}}\par\pard\plain\cf1\f51\fs20\ql they may act as agents or to whom they may sell as principal. Because there is no minimum offering amount required as a\plain\cf1\f51\fs20\ql condition to this offering, the actual total public offering amount, commissions and proceeds to us, if any, are not determinable at\plain\cf1\f51\fs20\ql this time. Pursuant to the terms of the sales agreement, we agreed to reimburse Wainwright for the documented fees and costs of\plain\cf1\f51\fs20\ql its legal counsel up to $50,000. Additionally, pursuant to the terms of the sales agreement, at the end of each calendar quarter\plain\cf1\f51\fs20\ql during the term of the sales agreement, we have agreed to reimburse Wainwright up to $5,000 for certain documented fees and\plain\cf1\f51\fs20\ql costs of its legal counsel. We estimate that the total expenses of the offering payable by us, excluding commissions payable to\plain\cf1\f51\fs20\ql Wainwright under the sales agreement, will be approximately $160,000.\par\pard\plain\sb264\fi462\cf1\f51\fs20\ql We will report at least quarterly the number of shares of common stock sold through Wainwright under the sales agreement,\plain\cf1\f51\fs20\ql the net proceeds to us and the compensation paid by us to Wainwright in connection with the sales of common stock.\par\pard\plain\sb264\fi462\cf1\f51\fs20\ql In connection with the sales of the common stock on our behalf, Wainwright may be deemed to be an\plain\cf1\f51\fs20\ql \u8220?underwriter\u8221? within the meaning of the Securities Act, and the compensation paid to Wainwright may be deemed\plain\cf1\f51\fs20\ql to be underwriting commissions or discounts. We have agreed in the sales agreement to provide indemnification and contribution\plain\cf1\f51\fs20\ql to Wainwright against certain liabilities, including liabilities under the Securities Act.\par\pard\plain\sb264\fi462\cf1\f51\fs20\ql The offering of our shares of common stock pursuant to the sales agreement will terminate upon the earlier of the (i)\~sale of\plain\cf1\f51\fs20\ql all of our shares of common stock provided for in this prospectus supplement, or (ii)\~termination of the sales agreement as\plain\cf1\f51\fs20\ql permitted therein.\par\pard\plain\sb264\fi462\cf1\f51\fs20\ql Wainwright and its affiliates may in the future provide various investment banking and other financial services for us and\plain\cf1\f51\fs20\ql our affiliates, for which services they may in the future receive customary fees. To the extent required by Regulation M,\plain\cf1\f51\fs20\ql Wainwright will not engage in any market making activities involving our shares of common stock while the offering is ongoing\plain\cf1\f51\fs20\ql under this prospectus supplement. This summary of the material provisions of the sales agreement does not purport to be a\plain\cf1\f51\fs20\ql complete statement of its terms and conditions. We are filing a copy of the sales agreement with the SEC on a Current Report on\plain\cf1\f51\fs20\ql Form 8-K concurrently with the filing of this prospectus supplement.{\*\bkmkstart supprom357361_9_11558912}{\*\bkmkend supprom357361_9_11558912}\par\pard\plain\sb528\cf1\f51\fs20\b\qc LEGAL MATTERS\par\pard\plain\sb264\fi462\cf1\f51\fs20\ql The validity of the securities offered hereby will be passed upon for us by Wilson Sonsini Goodrich\~& Rosati Professional\plain\cf1\f51\fs20\ql Corporation, Austin, Texas. H.C. Wainwright\~& Co., LLC is being represented in connection with this offering by Duane Morris\plain\cf1\f51\fs20\ql LLP, Newark, New Jersey.{\*\bkmkstart supprom357361_10_11558912}{\*\bkmkend supprom357361_10_11558912}\par\pard\plain\sb528\cf1\f51\fs20\b\qc EXPERTS\par\pard\plain\sb264\cf1\f51\fs20\b\ql Savara Inc.\par\pard\plain\sb132\fi462\cf1\f51\fs20\ql The audited historical financial statements of Savara Inc. included on page 103 of Savara Inc.\u8217?s Current Report on\plain\cf1\f51\fs20\ql Form 8-K dated April\~27, 2017 have been so incorporated in reliance on the report (which contains an explanatory paragraph\plain\cf1\f51\fs20\ql related to Savara Inc\u8217?s liquidity position as described in Note 1 to the financial statements) of PricewaterhouseCoopers\plain\cf1\f51\fs20\ql LLP, an independent registered public accounting firm, given on the authority of said firm as experts in auditing and accounting.\par\pard\plain\sb396\cf1\f51\fs20\b\ql Mast Therapeutics Inc.\par\pard\plain\sb132\fi462\cf1\f51\fs20\ql The consolidated financial statements of Savara Inc. (f/k/a Mast Therapeutics, Inc.) as of December\~31, 2016 and for the\plain\cf1\f51\fs20\ql year ended December\~31, 2016, and management\u8217?s assessment of the effectiveness of internal\par\pard\plain\cf1\f51\fs16\ql \~\par\pard\plain\cf1\f51\fs20\qc S-9
\page\par\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par\par\pard\plain\ul{\field{\*\fldinst HYPERLINK \\l "toc_11558912" }{\*\fldrslt\cf3\f52\fs16\b\ql Table of Contents}}\par\pard\plain\cf1\f51\fs20\ql control over financial reporting (which is included in Management\u8217?s Report on Internal Control over Financial Reporting\plain\cf1\f51\fs20\ql as of December\~31, 2016), have been incorporated by reference herein in reliance on the report (which contains an explanatory\plain\cf1\f51\fs20\ql paragraph relating to the uncertainty of the company\u8217?s ability to continue as a going concern as described in Note 1 to the\plain\cf1\f51\fs20\ql financial statements) of Mayer Hoffman McCann P.C., an independent registered public accounting firm, given on the authority\plain\cf1\f51\fs20\ql of said firm as experts in auditing and accounting.\par\pard\plain\sb264\fi462\cf1\f51\fs20\ql The financial statements of Mast Therapeutics Inc. as of December\~31, 2015 and for each of the two years in the period\plain\cf1\f51\fs20\ql ended December\~31, 2015 incorporated in this Prospectus supplement by reference to the Annual Report on Form 10-K for the\plain\cf1\f51\fs20\ql year ended December\~31, 2016 have been so incorporated in reliance on the report (which contains an explanatory paragraph\plain\cf1\f51\fs20\ql relating to Mast Therapeutics, Inc.\u8217?s liquidity position as described in Note 1 to the financial statements) of\plain\cf1\f51\fs20\ql PricewaterhouseCoopers LLP, an independent registered public accounting firm, given on the authority of said firm as experts in\plain\cf1\f51\fs20\ql auditing and accounting.{\*\bkmkstart supprom357361_11_11558912}{\*\bkmkend supprom357361_11_11558912}\par\pard\plain\sb528\cf1\f51\fs20\b\qc WHERE YOU CAN FIND ADDITIONAL INFORMATION\par\pard\plain\sb264\fi462\cf1\f51\fs20\ql We file annual, quarterly and current reports, proxy statements and other information with the SEC. You may read and copy\plain\cf1\f51\fs20\ql any reports, statements and other information filed by us at the SEC\u8217?s Public Reference Room at 100 F Street, N.E.,\plain\cf1\f51\fs20\ql Washington, D.C. 20549. Please call (800)\~SEC-0330 for further information on the Public Reference Room. The SEC maintains\plain\cf1\f51\fs20\ql an Internet website that contains reports, proxy and information statements and other information regarding issuers, including us,\plain\cf1\f51\fs20\ql that file electronically with the SEC. The address for the SEC\u8217?s website is\plain\cf1\f51\fs20\i\ql http://www.sec.gov.\par\pard\plain\sb264\fi462\cf1\f51\fs20\ql We make available, free of charge, through our investor relations website, our Annual Reports on Form 10-K, Quarterly\plain\cf1\f51\fs20\ql Reports on Form 10-Q, Current Reports on Form 8-K, statements of changes in beneficial ownership of securities and\plain\cf1\f51\fs20\ql amendments to those reports and statements as soon as reasonably practicable after they are filed with the SEC. The address for\plain\cf1\f51\fs20\ql our website is\plain\cf1\f51\fs20\i\ql http://www.savarapharma.com\plain\cf1\f51\fs20\ql . The contents on our website are not part of this prospectus supplement, and the\plain\cf1\f51\fs20\ql reference to our website does not constitute incorporation by reference into this prospectus supplement of the information\plain\cf1\f51\fs20\ql contained at that site.{\*\bkmkstart supprom357361_12_11558912}{\*\bkmkend supprom357361_12_11558912}\par\pard\plain\sb528\cf1\f51\fs20\b\qc INCORPORATION OF CERTAIN INFORMATION BY REFERENCE\par\pard\plain\sb264\fi462\cf1\f51\fs20\ql The SEC allows us to \u8220?incorporate by reference\u8221? into this prospectus supplement the information we file with\plain\cf1\f51\fs20\ql the SEC. This means that we can disclose important information to you by referring you to those documents. Any statement\plain\cf1\f51\fs20\ql contained in a document incorporated by reference in this prospectus supplement shall be deemed to be modified or superseded\plain\cf1\f51\fs20\ql for purposes of this prospectus supplement to the extent that a statement contained herein, or in any subsequently filed document,\plain\cf1\f51\fs20\ql which also is incorporated by reference herein, modifies or supersedes such earlier statement. Any such statement so modified or\plain\cf1\f51\fs20\ql superseded shall not be deemed, except as so modified or superseded, to constitute a part of this prospectus supplement.\par\pard\plain\sb264\fi462\cf1\f51\fs20\ql We hereby incorporate by reference into this prospectus supplement the following documents that we have filed with the\plain\cf1\f51\fs20\ql SEC under the Exchange Act File No.\~001-32157 (other than current reports on Form 8-K, or portions thereof, furnished under\plain\cf1\f51\fs20\ql Items 2.02 or 7.01 of Form 8-K):\par\pard\plain\cf1\f51\fs12\ql \~
\par\pard\plain
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh495
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql our Annual Report on Form 10-K for the fiscal year ended December\~31, 2016, filed with the SEC\plain\intbl\cf1\f51\fs20\ql on March\~6, 2017 (the \u8220?Annual Report\u8221?);\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh495\row}}}\pard\plain\cf1\f51\fs12\ql \~
\par\pard\plain
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh990
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql our Current Reports on Form 8-K filed with the SEC on January\~9, 2017 (two filings); January\~23,\plain\intbl\cf1\f51\fs20\ql 2017;\~January\~26, 2017;\~March\~6, 2017 (two filings); March\~16, 2017;\~March\~28, 2017;\~April\~10, 2017;\~April\~11,\plain\intbl\cf1\f51\fs20\ql 2017;\~April\~17, 2017;\~April\~20, 2017;\~April\~21, 2017;\~April\~24, 2017,\~April\~25, 2017,\~April\~27, 2017 and April\~28,\plain\intbl\cf1\f51\fs20\ql 2017; and\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh990\row}}}\pard\plain\cf1\f51\fs12\ql \~
\par\pard\plain
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh742
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql the description of our common stock contained in our registration statement on Form 8-A filed with the SEC on\plain\intbl\cf1\f51\fs20\ql April\~27, 2017 (File No.\~001-32157), including any amendments thereto or reports filed for the purposes of\plain\intbl\cf1\f51\fs20\ql updating this description.\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh742\row}}}\pard\plain\cf1\f51\fs16\ql \~\par\pard\plain\cf1\f51\fs20\qc S-10
\page\par\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par\par\pard\plain\ul{\field{\*\fldinst HYPERLINK \\l "toc_11558912" }{\*\fldrslt\cf3\f52\fs16\b\ql Table of Contents}}\par\pard\plain\fi462\cf1\f51\fs20\ql All documents that we file with the SEC pursuant to Section\~13(a), 13(c), 14 or 15(d) of the Exchange Act (other than\plain\cf1\f51\fs20\ql current reports on Form 8-K, or portions thereof, furnished under Items 2.02 or 7.01 of Form 8-K) (i)\~after the initial filing date\plain\cf1\f51\fs20\ql of the registration statement of which this prospectus supplement forms a part and prior to the effectiveness of such registration\plain\cf1\f51\fs20\ql statement and (ii)\~after the date of this prospectus supplement and prior to the termination of this offering shall be deemed to be\plain\cf1\f51\fs20\ql incorporated by reference in this prospectus supplement from the date of filing of the documents, unless we specifically provide\plain\cf1\f51\fs20\ql otherwise. Information that we file with the SEC will automatically update and may replace information previously filed with the\plain\cf1\f51\fs20\ql SEC. To the extent that any information contained in any current report on Form 8-K or any exhibit thereto, was or is furnished\plain\cf1\f51\fs20\ql to, rather than filed with the SEC, such information or exhibit is specifically not incorporated by reference.\par\pard\plain\sb264\fi462\cf1\f51\fs20\ql Upon written or oral request made to us at the address or telephone number below, we will, at no cost to the requester,\plain\cf1\f51\fs20\ql provide to each person, including any beneficial owner, to whom this prospectus supplement is delivered, a copy of any or all of\plain\cf1\f51\fs20\ql the information that has been incorporated by reference in this prospectus supplement (other than an exhibit to a filing, unless\plain\cf1\f51\fs20\ql that exhibit is specifically incorporated by reference into that filing), but not delivered with this prospectus supplement. You may\plain\cf1\f51\fs20\ql also access this information on our website at www.savarapharma.com by viewing the \u8220?SEC Filings\u8221? subsection of\plain\cf1\f51\fs20\ql the \u8220?Investors\u8221? menu. No additional information on our website is deemed to be part of or incorporated by\plain\cf1\f51\fs20\ql reference into this prospectus supplement. We have included our website address in this prospectus supplement solely as an\plain\cf1\f51\fs20\ql inactive textual reference.\par\pard\plain\sb264\cf1\f51\fs20\qc Savara Inc.\par\pard\plain\cf1\f51\fs20\qc 900 S. Capital of Texas Highway\par\pard\plain\cf1\f51\fs20\qc Las Cimas IV, Suite 150\par\pard\plain\cf1\f51\fs20\qc Austin, Texas 78746\par\pard\plain\cf1\f51\fs20\qc Attn: Investor Relations\par\pard\plain\cf1\f51\fs20\qc Tel: (512)\~961-1891\par\pard\plain\cf1\f51\fs16\ql \~\par\pard\plain\cf1\f51\fs20\qc S-11
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\par\pard\plain\sb264\cf1\f51\fs32\b\qc $150,000,000\par\pard\plain\sb264\cf1\f51\fs20\b\qc Common Stock\par\pard\plain\cf1\f51\fs20\b\qc Preferred Stock\par\pard\plain\cf1\f51\fs20\b\qc Debt Securities\par\pard\plain\cf1\f51\fs20\b\qc Warrants\par\pard\plain\cf1\f51\fs20\b\qc Units\par\pard\plain\sb264\fi462\cf1\f51\fs20\ql We may, from time to time in one or more offerings, offer and sell up to $150,000,000 in the aggregate of common stock,\plain\cf1\f51\fs20\ql preferred stock, debt securities, warrants to purchase common stock, preferred stock or debt securities, or any combination of the\plain\cf1\f51\fs20\ql foregoing, either individually or as units comprised of one or more of the other securities.\par\pard\plain\sb264\fi462\cf1\f51\fs20\ql This prospectus provides a general description of the securities we may offer. We will provide the specific terms of the\plain\cf1\f51\fs20\ql securities offered in one or more supplements to this prospectus. We may also authorize one or more free writing prospectuses to\plain\cf1\f51\fs20\ql be provided to you in connection with these offerings. The prospectus supplement and any related free writing prospectus may\plain\cf1\f51\fs20\ql add, update or change information contained in this prospectus. You should read carefully this prospectus, the applicable\plain\cf1\f51\fs20\ql prospectus supplement and any related free writing prospectus, as well as the documents incorporated by reference before you\plain\cf1\f51\fs20\ql invest in any of our securities.\plain\cf1\f51\fs20\b\ql This prospectus may not be used to offer or sell any securities unless accompanied by the\plain\cf1\f51\fs20\b\ql applicable prospectus supplement.\par\pard\plain\sb264\fi462\cf1\f51\fs20\ql Our common stock is listed on the NYSE MKT under the symbol \u8220?MSTX.\u8221? On March\~23, 2015, the last\plain\cf1\f51\fs20\ql reported sale price for our common stock was $0.52 per share.\par\pard\plain\sb264\fi594\cf1\f51\fs24\b\ql Investing in our securities involves a high degree of risk. See \u8220?\pard\plain\sb264\ul{\field{\*\fldinst HYPERLINK \\l "toc893420_3_11558912" }{\*\fldrslt\cf3\f51\fs24\b\ql Risk Factors}}\plain\cf1\f51\fs24\b\ql \u8221? on page 5 of this prospectus and in the documents incorporated by reference in this\plain\cf1\f51\fs24\b\ql prospectus, as updated in the applicable prospectus supplement, any related free writing prospectus\plain\cf1\f51\fs24\b\ql and other future filings we make with the Securities and Exchange Commission that are incorporated\plain\cf1\f51\fs24\b\ql by reference into this prospectus, for a discussion of the factors you should consider carefully before\plain\cf1\f51\fs24\b\ql deciding to purchase our securities.\par\pard\plain\sb264\fi462\cf1\f51\fs20\ql We will sell these securities directly to investors, through agents designated from time to time or to or through underwriters\plain\cf1\f51\fs20\ql or dealers. For additional information on the methods of sale, you should refer to the section entitled \u8220?Plan of\plain\cf1\f51\fs20\ql Distribution\u8221? in this prospectus. If any underwriters are involved in the sale of any securities with respect to which this\plain\cf1\f51\fs20\ql prospectus is being delivered, the names of such underwriters and any applicable commissions or discounts will be set forth in a\plain\cf1\f51\fs20\ql prospectus supplement. The price to the public of such securities and the net proceeds we expect to receive from such sale will\plain\cf1\f51\fs20\ql also be set forth in a prospectus supplement.\par\pard\plain\sb264\fi462\cf1\f51\fs20\b\ql Neither the Securities and Exchange Commission nor any state securities commission has approved or disapproved of\plain\cf1\f51\fs20\b\ql these securities or determined if this prospectus is truthful or complete.\~Any representation to the contrary is a criminal\plain\cf1\f51\fs20\b\ql offense.\par\pard\plain\sb264\cf1\f51\fs20\qc The date of this prospectus is August 19, 2015
\page\par\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par\par\pard\plain\ul{\field{\*\fldinst HYPERLINK \\l "toc_11558912" }{\*\fldrslt\cf3\f52\fs16\b\ql Table of Contents}}\par\pard\plain\cf1\f51\fs20\b\qc TABLE OF CONTENTS\par\pard\plain\cf1\f51\fs24\ql \~
\par\pard\plain
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\pard\plain\intbl\li176\ul{\field{\*\fldinst HYPERLINK \\l "toc357361_1_11558912" }{\*\fldrslt\cf3\f51\fs20\ql ABOUT THIS PROSPECTUS}}\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr ii\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell{
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\pard\plain\intbl\li176\ul{\field{\*\fldinst HYPERLINK \\l "toc357361_16_11558912" }{\*\fldrslt\cf3\f51\fs20\ql WHERE YOU CAN FIND MORE INFORMATION}}\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\qr 27\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell{
{\trowd\cellx10205\clvertalb\cellx10419\clvertalb\cellx10489\clvertalb\cellx10709\clvertalb\cellx10800\trrh248\row}}}\pard\plain\cf1\f51\fs16\ql \~\par\pard\plain\cf1\f51\fs20\qc i
\page\par\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par\par\pard\plain\ul{\field{\*\fldinst HYPERLINK \\l "toc_11558912" }{\*\fldrslt\cf3\f52\fs16\b\ql Table of Contents}}{\*\bkmkstart toc357361_1_11558912}{\*\bkmkend toc357361_1_11558912}\par\pard\plain\cf1\f51\fs20\b\qc ABOUT THIS PROSPECTUS\par\pard\plain\sb264\cf1\f51\fs20\ql This prospectus is part of a registration statement that we filed with the Securities and Exchange Commission, or the SEC, under\plain\cf1\f51\fs20\ql the Securities Act of 1933, as amended, or the Securities Act, using a \u8220?shelf\u8221? registration process. Under this shelf\plain\cf1\f51\fs20\ql registration process, we may from time to time sell common stock, preferred stock, debt securities or warrants to purchase\plain\cf1\f51\fs20\ql common stock, preferred stock or debt securities, or any combination of the foregoing, either individually or as units comprised\plain\cf1\f51\fs20\ql of one or more of the other securities, in one or more offerings up to a total dollar amount of $150,000,000. We have provided\plain\cf1\f51\fs20\ql to you in this prospectus a general description of the securities we may offer. Each time we sell securities under this shelf\plain\cf1\f51\fs20\ql registration, we will, to the extent required by law, provide a prospectus supplement that will contain specific information about\plain\cf1\f51\fs20\ql the terms of that offering. We may also authorize one or more free writing prospectuses to be provided to you that may contain\plain\cf1\f51\fs20\ql material information relating to these offerings. The prospectus supplement and any related free writing prospectus that we may\plain\cf1\f51\fs20\ql authorize to be provided to you may also add, update or change information contained in this prospectus or in any documents\plain\cf1\f51\fs20\ql that we have incorporated by reference into this prospectus. To the extent there is a conflict between the information contained in\plain\cf1\f51\fs20\ql this prospectus and the prospectus supplement or any related free writing prospectus, you should rely on the information in the\plain\cf1\f51\fs20\ql prospectus supplement or the related free writing prospectus; provided that if any statement in one of these documents is\plain\cf1\f51\fs20\ql inconsistent with a statement in another document having a later date \u8212? for example, a document filed after the date of this\plain\cf1\f51\fs20\ql prospectus and incorporated by reference into this prospectus or any prospectus supplement or any related free writing perspective\plain\cf1\f51\fs20\ql \u8212? the statement in the document having the later date modifies or supersedes the earlier statement\par\pard\plain\sb264\cf1\f51\fs20\ql We have not authorized any dealer, agent or other person to give any information or to make any representation other than those\plain\cf1\f51\fs20\ql contained or incorporated by reference in this prospectus and any accompanying prospectus supplement, or any related free\plain\cf1\f51\fs20\ql writing prospectus that we may authorize to be provided to you. You must not rely upon any information or representation not\plain\cf1\f51\fs20\ql contained or incorporated by reference in this prospectus or an accompanying prospectus supplement, or any related free writing\plain\cf1\f51\fs20\ql prospectus that we may authorize to be provided to you. This prospectus and the accompanying prospectus supplement, if any, do\plain\cf1\f51\fs20\ql not constitute an offer to sell or the solicitation of an offer to buy any securities other than the registered securities to which they\plain\cf1\f51\fs20\ql relate, nor do this prospectus and the accompanying prospectus supplement constitute an offer to sell or the solicitation of an\plain\cf1\f51\fs20\ql offer to buy securities in any jurisdiction to any person to whom it is unlawful to make such offer or solicitation in such\plain\cf1\f51\fs20\ql jurisdiction. You should not assume that the information contained in this prospectus, any applicable prospectus supplement or\plain\cf1\f51\fs20\ql any related free writing prospectus is accurate on any date subsequent to the date set forth on the front of the document or that\plain\cf1\f51\fs20\ql any information we have incorporated by reference is correct on any date subsequent to the date of the document incorporated by\plain\cf1\f51\fs20\ql reference (as our business, financial condition, results of operations and prospects may have changed since that date), even\plain\cf1\f51\fs20\ql though this prospectus, any applicable prospectus supplement or any related free writing prospectus is delivered or securities are\plain\cf1\f51\fs20\ql sold on a later date.\par\pard\plain\sb264\cf1\f51\fs20\ql As permitted by SEC rules and regulations, the registration statement of which this prospectus forms a part includes additional\plain\cf1\f51\fs20\ql information not contained in this prospectus. You may read the registration statement and the other reports we file with the SEC\plain\cf1\f51\fs20\ql at its web site or at its offices described below under \u8220?Where You Can Find More Information.\u8221?\par\pard\plain\cf1\f51\fs16\ql \~\par\pard\plain\cf1\f51\fs20\qc ii
\page\par\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par\par\pard\plain\ul{\field{\*\fldinst HYPERLINK \\l "toc_11558912" }{\*\fldrslt\cf3\f52\fs16\b\ql Table of Contents}}{\*\bkmkstart toc357361_2_11558912}{\*\bkmkend toc357361_2_11558912}\par\pard\plain\li22\ri-22\cf1\f51\fs20\b\qc SUMMARY\par\pard\plain\li22\ri-22\sb264\fi440\cf1\f51\fs20\i\ql This summary highlights the information contained elsewhere in or incorporated by reference into this prospectus.\plain\li22\ri-22\cf1\f51\fs20\i\ql Because this is only a summary, it does not contain all of the information that you should consider before investing in our\plain\li22\ri-22\cf1\f51\fs20\i\ql securities. You should carefully read this entire prospectus, including the information contained under the heading\plain\li22\ri-22\cf1\f51\fs20\i\ql \u8220?Risk Factors,\u8221? and all other information included or incorporated by reference into this prospectus in their\plain\li22\ri-22\cf1\f51\fs20\i\ql entirety before you invest in our securities.\par\pard\plain\li22\ri-22\sb264\fi440\cf1\f51\fs20\i\ql Unless the context otherwise requires, all references in this prospectus to \u8220?Mast,\u8221? \u8220?we,\u8221?\plain\li22\ri-22\cf1\f51\fs20\i\ql \u8220?us,\u8221? \u8220?our,\u8221? \u8220?the Company\u8221? or similar words refer to Mast Therapeutics, Inc.,\plain\li22\ri-22\cf1\f51\fs20\i\ql together with our consolidated subsidiaries.\par\pard\plain\li22\ri-22\sb396\cf1\f51\fs20\b\ql Company Overview\par\pard\plain\li22\ri-22\sb132\fi440\cf1\f51\fs20\ql We are a clinical-stage, biopharmaceutical company developing novel therapies for serious or life-threatening\plain\li22\ri-22\cf1\f51\fs20\ql diseases with significant unmet needs. We are leveraging our Molecular Adhesion\~& Sealant Technology, or MAST,\plain\li22\ri-22\cf1\f51\fs20\ql platform, derived from over two decades of clinical, nonclinical, and manufacturing experience with purified and\plain\li22\ri-22\cf1\f51\fs20\ql non-purified poloxamers, to develop MST-188 (vepoloxamer) Injection, our lead product candidate. Vepoloxamer has\plain\li22\ri-22\cf1\f51\fs20\ql demonstrated multiple pharmacologic effects that may provide clinical benefit in a wide range of diseases and conditions\plain\li22\ri-22\cf1\f51\fs20\ql typically characterized by impaired microvascular blood flow and/or damaged cell membranes. We currently are developing\plain\li22\ri-22\cf1\f51\fs20\ql vepoloxamer for the treatment of sickle cell disease, arterial disease (in combination with thrombolytics), and heart failure.\plain\li22\ri-22\cf1\f51\fs20\ql We also are developing AIR001, a sodium nitrite solution for intermittent inhalation via nebulizer. AIR001 has\plain\li22\ri-22\cf1\f51\fs20\ql demonstrated positive hemodynamic effects in patients with pulmonary hypertension and we are developing it for the\plain\li22\ri-22\cf1\f51\fs20\ql treatment of heart failure with preserved ejection fraction, or HFpEF.\par\pard\plain\li22\ri-22\sb264\fi440\cf1\f51\fs20\ql We have devoted substantially all of our resources to research and development and to acquisition of our product\plain\li22\ri-22\cf1\f51\fs20\ql candidates. We have not yet marketed or sold any products or generated any significant revenue and we have incurred\plain\li22\ri-22\cf1\f51\fs20\ql significant annual operating losses since inception. We incurred losses from operations of $29.3 million and $21.5 million\plain\li22\ri-22\cf1\f51\fs20\ql for the years ended December\~31, 2014 and December\~31, 2013, respectively. As of December\~31, 2014, we had an\plain\li22\ri-22\cf1\f51\fs20\ql accumulated deficit of $235.1 million. Our cash, cash equivalents, and investment securities were $57.3 million as of\plain\li22\ri-22\cf1\f51\fs20\ql December\~31, 2014.\par\pard\plain\li22\ri-22\sb264\fi440\cf1\f51\fs20\ql We continue to focus our resources primarily on the development of vepoloxamer. In May 2013, we began enrolling\plain\li22\ri-22\cf1\f51\fs20\ql subjects in EPIC, a pivotal Phase 3 study of vepoloxamer in patients with sickle cell disease, and enrollment of that study\plain\li22\ri-22\cf1\f51\fs20\ql is one of our top priorities. We also are enrolling patients with acute limb ischemia in a Phase 2 study of vepoloxamer in\plain\li22\ri-22\cf1\f51\fs20\ql combination with recombinant tissue plasminogen activator to evaluate whether vepoloxamer improves effectiveness of\plain\li22\ri-22\cf1\f51\fs20\ql thrombolytic therapy. In addition, we are planning to initiate a Phase 2 study of vepoloxamer in patients with heart failure\plain\li22\ri-22\cf1\f51\fs20\ql in the third quarter of 2015. Our vepoloxamer pipeline also includes preclinical development programs in thrombotic stroke\plain\li22\ri-22\cf1\f51\fs20\ql and resuscitation following major trauma (i.e., restoration of circulating blood volume and pressure).\par\pard\plain\li22\ri-22\sb264\fi440\cf1\f51\fs20\ql Our second product candidate, AIR001, is being tested in multiple institution-sponsored Phase 2a clinical studies in\plain\li22\ri-22\cf1\f51\fs20\ql patients with HFpEF. We obtained the AIR001 program through our acquisition of Aires Pharmaceuticals, Inc. in February\plain\li22\ri-22\cf1\f51\fs20\ql 2014. Prior to the acquisition, AIR001 had been tested in more than 120 healthy volunteers and patients with various forms\plain\li22\ri-22\cf1\f51\fs20\ql of pulmonary hypertension and it demonstrated positive hemodynamic effects and was well-tolerated. If data from the\plain\li22\ri-22\cf1\f51\fs20\ql Phase 2a studies are positive, we expect to conduct a Phase 2b proof-of-concept study in HFpEF.\par\pard\plain\li22\ri-22\cf1\f51\fs16\ql \~
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\par\pard\plain\fs16\par\pard\plain\brdrb\brdrs\cf1\f51\fs16\ql \~\par\pard\plain\cf1\f51\fs20\qc 1
\page\par\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par\par\pard\plain\ul{\field{\*\fldinst HYPERLINK \\l "toc_11558912" }{\*\fldrslt\cf3\f52\fs16\b\ql Table of Contents}}\par\pard\plain\li22\ri-22\cf1\f51\fs20\b\ql Corporate Information\par\pard\plain\li22\ri-22\sb132\fi440\cf1\f51\fs20\ql In March 2013, we changed our name from \u8220?ADVENTRX Pharmaceuticals, Inc.\u8221? to \u8220?Mast\plain\li22\ri-22\cf1\f51\fs20\ql Therapeutics, Inc.\u8221?\par\pard\plain\li22\ri-22\sb264\fi440\cf1\f51\fs20\ql Our principal executive offices are located at 3611 Valley Centre Drive, Suite 500, San Diego, CA 92130 and our\plain\li22\ri-22\cf1\f51\fs20\ql telephone number at that address is (858)\~552-0866. Our corporate website is located at www.masttherapeutics.com. We\plain\li22\ri-22\cf1\f51\fs20\ql make available free of charge through our website our annual report on Form 10-K, quarterly reports on Form 10-Q,\plain\li22\ri-22\cf1\f51\fs20\ql current reports on Form 8-K, and amendments to those reports filed or furnished pursuant to Section\~13(a) or 15(d) of the\plain\li22\ri-22\cf1\f51\fs20\ql Securities Exchange Act of 1934, as amended, or the Exchange Act, as soon as reasonably practicable after we\plain\li22\ri-22\cf1\f51\fs20\ql electronically file such material with, or furnish it to, the SEC. The information contained in, or that can be accessed\plain\li22\ri-22\cf1\f51\fs20\ql through, our website is not part of this prospectus or any prospectus supplement.\par\pard\plain\li22\ri-22\sb396\cf1\f51\fs20\b\ql The Securities We May Offer\par\pard\plain\li22\ri-22\sb132\fi440\cf1\f51\fs20\ql We may offer shares of our common stock and preferred stock, various series of debt securities and warrants to\plain\li22\ri-22\cf1\f51\fs20\ql purchase any of such securities, either individually or in units, with a total value of up to $150,000,000 from time to time\plain\li22\ri-22\cf1\f51\fs20\ql under this prospectus, together with any applicable prospectus supplement and related free writing prospectus, at prices and\plain\li22\ri-22\cf1\f51\fs20\ql on terms to be determined by market conditions at the time of offering. If we issue any debt securities at a discount from\plain\li22\ri-22\cf1\f51\fs20\ql their original stated principal amount, then, for purposes of calculating the total dollar amount of all securities issued under\plain\li22\ri-22\cf1\f51\fs20\ql this prospectus, we will treat the initial offering price of the debt securities as the total original principal amount of the\plain\li22\ri-22\cf1\f51\fs20\ql debt securities. Each time we offer securities under this prospectus, we will provide offerees with a prospectus supplement\plain\li22\ri-22\cf1\f51\fs20\ql that will describe the specific amounts, prices and other important terms of the securities being offered, including, to the\plain\li22\ri-22\cf1\f51\fs20\ql extent applicable:\par\pard\plain\li22\ri-22\cf1\f51\fs12\ql \~
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{\trowd\clvertalc\cellx514\cellx1178\cellx1280\cellx10280\trrh248\row}}}\pard\plain\li22\ri-22\cf1\f51\fs12\ql \~
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{\trowd\clvertalc\cellx514\cellx1178\cellx1280\cellx10280\trrh248\row}}}\pard\plain\li22\ri-22\cf1\f51\fs12\ql \~
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\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql restrictive covenants, if any;\cell{
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\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql voting or other rights, if any; and\cell{
{\trowd\clvertalc\cellx514\cellx1178\cellx1280\cellx10280\trrh248\row}}}\pard\plain\li22\ri-22\cf1\f51\fs12\ql \~
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\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql important United States federal income tax considerations.\cell{
{\trowd\clvertalc\cellx514\cellx1178\cellx1280\cellx10280\trrh248\row}}}\pard\plain\li22\ri-22\sb264\fi440\cf1\f51\fs20\ql The prospectus supplement and any related free writing prospectus that we may authorize to be provided to you may\plain\li22\ri-22\cf1\f51\fs20\ql also add, update or change information contained in this prospectus or in documents we have incorporated by reference.\plain\li22\ri-22\cf1\f51\fs20\ql However, no prospectus supplement or free writing prospectus will offer a security that is not registered and described in\plain\li22\ri-22\cf1\f51\fs20\ql this prospectus at the time of the effectiveness of the registration statement of which this prospectus is a part.\par\pard\plain\li22\ri-22\cf1\f51\fs16\ql \~
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\par\pard\plain\fs16\par\pard\plain\brdrb\brdrs\cf1\f51\fs16\ql \~\par\pard\plain\cf1\f51\fs20\qc 2
\page\par\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par\par\pard\plain\ul{\field{\*\fldinst HYPERLINK \\l "toc_11558912" }{\*\fldrslt\cf3\f52\fs16\b\ql Table of Contents}}\par\pard\plain\li22\ri-22\fi440\cf1\f51\fs20\ql We may sell the securities to or through underwriters, dealers or agents or directly to purchasers. We, as well as any\plain\li22\ri-22\cf1\f51\fs20\ql agents acting on our behalf, reserve the sole right to accept and to reject in whole or in part any proposed purchase of\plain\li22\ri-22\cf1\f51\fs20\ql securities. Each prospectus supplement will set forth the names of any underwriters, dealers or agents involved in the sale\plain\li22\ri-22\cf1\f51\fs20\ql of securities described in that prospectus supplement and any applicable fee, commission or discount arrangements with\plain\li22\ri-22\cf1\f51\fs20\ql them, details regarding any over-allotment option granted to them, and net proceeds to us. The following is a summary of\plain\li22\ri-22\cf1\f51\fs20\ql the securities we may offer with this prospectus.\par\pard\plain\li88\ri-22\sb396\cf1\f51\fs20\b\i\ql Common Stock\par\pard\plain\li22\ri-22\sb132\fi440\cf1\f51\fs20\ql As of the date of this prospectus, our amended and restated certificate of incorporation, as amended, or our certificate\plain\li22\ri-22\cf1\f51\fs20\ql of incorporation, authorizes us to issue 500,000,000 shares of common stock, par value $0.001 per share, of which\plain\li22\ri-22\cf1\f51\fs20\ql 159,458,376 shares were issued and outstanding as of March\~20, 2015. We may offer shares of our common stock either\plain\li22\ri-22\cf1\f51\fs20\ql alone or underlying other registered securities convertible into or exercisable for our common stock. Holders of our\plain\li22\ri-22\cf1\f51\fs20\ql common stock are entitled to such dividends as our board of directors may declare from time to time out of legally\plain\li22\ri-22\cf1\f51\fs20\ql available funds, subject to the preferential rights of the holders of any shares of our preferred stock that are outstanding or\plain\li22\ri-22\cf1\f51\fs20\ql that we may issue in the future. Currently, we do not pay any dividends on our common stock. Each holder of our\plain\li22\ri-22\cf1\f51\fs20\ql common stock is entitled to one vote per share. In this prospectus, we provide a general description of, among other things,\plain\li22\ri-22\cf1\f51\fs20\ql the rights and restrictions that apply to holders of our common stock.\par\pard\plain\li88\ri-22\sb396\cf1\f51\fs20\b\i\ql Preferred Stock\par\pard\plain\li22\ri-22\sb132\fi440\cf1\f51\fs20\ql As of the date of this prospectus, our certificate of incorporation authorizes us to issue 1,000,000 shares of preferred\plain\li22\ri-22\cf1\f51\fs20\ql stock, par value $0.001 per share, none of which are outstanding. We may issue shares of our preferred stock from time to\plain\li22\ri-22\cf1\f51\fs20\ql time, in one or more series.\par\pard\plain\li22\ri-22\sb264\fi440\cf1\f51\fs20\ql Any authorized and undesignated shares of preferred stock may be issued with such rights and powers as the board of\plain\li22\ri-22\cf1\f51\fs20\ql directors may designate. Under our certificate of incorporation, our board of directors has the authority to issue shares of\plain\li22\ri-22\cf1\f51\fs20\ql our preferred stock in one or more series and to fix or alter the rights, preferences, privileges and restrictions granted to or\plain\li22\ri-22\cf1\f51\fs20\ql imposed upon any series of preferred stock. The particular terms of each class or series of preferred stock, including\plain\li22\ri-22\cf1\f51\fs20\ql redemption privileges, liquidation preferences, voting rights, dividend rights and/or conversion rights, will be more fully\plain\li22\ri-22\cf1\f51\fs20\ql described in the applicable prospectus supplement relating to the preferred stock offered thereby.\par\pard\plain\li22\ri-22\sb264\fi440\cf1\f51\fs20\ql The rights, preferences, privileges and restrictions granted to or imposed upon any series of preferred stock that we\plain\li22\ri-22\cf1\f51\fs20\ql offer and sell under this prospectus and applicable prospectus supplements will be set forth in a certificate of designation\plain\li22\ri-22\cf1\f51\fs20\ql relating to the series. We will file as an exhibit to the registration statement of which this prospectus is a part, or will\plain\li22\ri-22\cf1\f51\fs20\ql incorporate by reference from another report that we file with the SEC, the form of any certificate of designation that\plain\li22\ri-22\cf1\f51\fs20\ql describes the terms of any series of preferred stock we offer under this prospectus before the issuance of shares of that\plain\li22\ri-22\cf1\f51\fs20\ql series of preferred stock. You should read any prospectus supplement and any free writing prospectus that we may\plain\li22\ri-22\cf1\f51\fs20\ql authorize to be provided to you related to the series of preferred stock being offered, as well as the complete certificate of\plain\li22\ri-22\cf1\f51\fs20\ql designation that contains the terms of the applicable series of preferred stock.\par\pard\plain\li88\ri-22\sb396\cf1\f51\fs20\b\i\ql Debt Securities\par\pard\plain\li22\ri-22\sb132\fi440\cf1\f51\fs20\ql We may offer general debt obligations, which may be secured or unsecured, senior or subordinated and convertible\plain\li22\ri-22\cf1\f51\fs20\ql into shares of our common stock. In this prospectus, we refer to the senior debt securities and the subordinated debt\plain\li22\ri-22\cf1\f51\fs20\ql securities together as the \u8220?debt securities.\u8221? We may issue debt securities under a note purchase agreement or\plain\li22\ri-22\cf1\f51\fs20\ql under an indenture to be entered between us and a trustee; forms of the senior and subordinated\par\pard\plain\li22\ri-22\cf1\f51\fs16\ql \~
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\page\par\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par\par\pard\plain\ul{\field{\*\fldinst HYPERLINK \\l "toc_11558912" }{\*\fldrslt\cf3\f52\fs16\b\ql Table of Contents}}\par\pard\plain\li22\ri-22\cf1\f51\fs20\ql indentures are included as an exhibit to the registration statement of which this prospectus is a part. The indentures do not\plain\li22\ri-22\cf1\f51\fs20\ql limit the amount of securities that may be issued under it and provides that debt securities may be issued in one or more\plain\li22\ri-22\cf1\f51\fs20\ql series. The senior debt securities will have the same rank as all of our other indebtedness that is not subordinated. The\plain\li22\ri-22\cf1\f51\fs20\ql subordinated debt securities will be subordinated to our senior debt on terms set forth in the applicable prospectus\plain\li22\ri-22\cf1\f51\fs20\ql supplement. In addition, the subordinated debt securities will be effectively subordinated to creditors and preferred\plain\li22\ri-22\cf1\f51\fs20\ql stockholders of our subsidiaries. Our board of directors will determine the terms of each series of debt securities being\plain\li22\ri-22\cf1\f51\fs20\ql offered. This prospectus contains only general terms and provisions of the debt securities. The applicable prospectus\plain\li22\ri-22\cf1\f51\fs20\ql supplement will describe the particular terms of the debt securities offered thereby. You should read any prospectus\plain\li22\ri-22\cf1\f51\fs20\ql supplement and any free writing prospectus that we may authorize to be provided to you related to the series of debt\plain\li22\ri-22\cf1\f51\fs20\ql securities being offered, as well as the complete note agreements and/or indentures that contain the terms of the debt\plain\li22\ri-22\cf1\f51\fs20\ql securities. Forms of indentures have been filed as exhibits to the registration statement of which this prospectus is a part,\plain\li22\ri-22\cf1\f51\fs20\ql and supplemental indentures and forms of debt securities containing the terms of debt securities we offer under this\plain\li22\ri-22\cf1\f51\fs20\ql prospectus will be filed as exhibits to the registration statement of which this prospectus is a part, or will be incorporated\plain\li22\ri-22\cf1\f51\fs20\ql by reference from another report that we file with the SEC.\par\pard\plain\li88\ri-22\sb396\cf1\f51\fs20\b\i\ql Warrants\par\pard\plain\li22\ri-22\sb132\fi440\cf1\f51\fs20\ql We may offer warrants for the purchase of shares of our common stock or preferred stock or of debt securities. We\plain\li22\ri-22\cf1\f51\fs20\ql may issue the warrants by themselves or together with common stock, preferred stock or debt securities, and the warrants\plain\li22\ri-22\cf1\f51\fs20\ql may be attached to or separate from any offered securities. Our board of directors will determine the terms of the warrants.\plain\li22\ri-22\cf1\f51\fs20\ql This prospectus contains only general terms and provisions of the warrants. The applicable prospectus supplement will\plain\li22\ri-22\cf1\f51\fs20\ql describe the particular terms of the warrants being offered thereby. You should read any prospectus supplement and any\plain\li22\ri-22\cf1\f51\fs20\ql free writing prospectus that we may authorize to be provided to you related to the series of warrants being offered, as well\plain\li22\ri-22\cf1\f51\fs20\ql as the complete form of warrant and/or the warrant agreement and warrant certificate, as applicable, that contain the terms\plain\li22\ri-22\cf1\f51\fs20\ql of the warrants. We will file as an exhibit to the registration statement of which this prospectus is a part, or will\plain\li22\ri-22\cf1\f51\fs20\ql incorporate by reference from another report that we file with the SEC, the form of warrant and/or the warrant agreement\plain\li22\ri-22\cf1\f51\fs20\ql and warrant certificate, as applicable, that contain the terms of the particular series of warrants we are offering, and any\plain\li22\ri-22\cf1\f51\fs20\ql supplemental agreements, before the issuance of such warrants.\par\pard\plain\li88\ri-22\sb396\cf1\f51\fs20\b\i\ql Units\par\pard\plain\li22\ri-22\sb132\fi440\cf1\f51\fs20\ql We may offer units consisting of our common stock or preferred stock, debt securities and/or warrants to purchase\plain\li22\ri-22\cf1\f51\fs20\ql any of these securities in one or more series. We may evidence each series of units by unit certificates that we will issue\plain\li22\ri-22\cf1\f51\fs20\ql under a separate agreement. We may enter into unit agreements with a unit agent. Each unit agent will be a bank or trust\plain\li22\ri-22\cf1\f51\fs20\ql company that we select. We will indicate the name and address of the unit agent in the applicable prospectus supplement\plain\li22\ri-22\cf1\f51\fs20\ql relating to a particular series of units. This prospectus contains only a summary of certain general features of the units. The\plain\li22\ri-22\cf1\f51\fs20\ql applicable prospectus supplement will describe the particular features of the units being offered thereby. You should read\plain\li22\ri-22\cf1\f51\fs20\ql any prospectus supplement and any free writing prospectus that we may authorize to be provided to you related to the\plain\li22\ri-22\cf1\f51\fs20\ql series of units being offered, as well as the complete unit agreements that contain the terms of the units. Specific unit\plain\li22\ri-22\cf1\f51\fs20\ql agreements will contain additional important terms and provisions and we will file as an exhibit to the registration\plain\li22\ri-22\cf1\f51\fs20\ql statement of which this prospectus is a part, or will incorporate by reference from another report that we file with the SEC,\plain\li22\ri-22\cf1\f51\fs20\ql the form of each unit agreement relating to units offered under this prospectus.\par\pard\plain\li22\ri-22\cf1\f51\fs16\ql \~
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\page\par\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par\par\pard\plain\ul{\field{\*\fldinst HYPERLINK \\l "toc_11558912" }{\*\fldrslt\cf3\f52\fs16\b\ql Table of Contents}}{\*\bkmkstart toc357361_3_11558912}{\*\bkmkend toc357361_3_11558912}\par\pard\plain\cf1\f51\fs20\b\qc RISK FACTORS\par\pard\plain\sb264\fi462\cf1\f51\fs20\ql Investing in our securities involves a high degree of risk. You should carefully consider the risk factors set forth under\plain\cf1\f51\fs20\ql \u8220?Risk Factors\u8221? in Item\~1A of our annual report on Form 10-K for the year ended December\~31, 2014, which is\plain\cf1\f51\fs20\ql incorporated by reference in this prospectus, together with all other information contained or incorporated by reference in this\plain\cf1\f51\fs20\ql prospectus, as may be updated by our subsequent filings under the Exchange Act, and the risk factors and other information\plain\cf1\f51\fs20\ql contained in any applicable prospectus supplement and in any related free writing prospectus in connection with a specific\plain\cf1\f51\fs20\ql offering, before deciding whether to purchase any of the securities being registered pursuant to the registration statement of which\plain\cf1\f51\fs20\ql this prospectus is a part. Each of the risk factors could adversely affect our business, operating results and financial condition, as\plain\cf1\f51\fs20\ql well as adversely affect the value of an investment in our securities, and the occurrence of any of these risks might cause you to\plain\cf1\f51\fs20\ql lose all or part of your investment. Additional risks and uncertainties that we do not presently know about or that we currently\plain\cf1\f51\fs20\ql believe are not material may also adversely affect our business.{\*\bkmkstart toc357361_4_11558912}{\*\bkmkend toc357361_4_11558912}\par\pard\plain\sb528\cf1\f51\fs20\b\qc SPECIAL NOTE REGARDING FORWARD-LOOKING STATEMENTS\par\pard\plain\sb264\fi462\cf1\f51\fs20\ql This prospectus and our SEC filings that are incorporated by reference into this prospectus contain or incorporate by\plain\cf1\f51\fs20\ql reference forward-looking statements within the meaning of Section\~27A of the Securities Act and Section\~21E of the Exchange\plain\cf1\f51\fs20\ql Act. All statements, other than statements of historical fact, included or incorporated by reference in this prospectus regarding our\plain\cf1\f51\fs20\ql development of our products, financial position, strategy, regulatory status, clinical and nonclinical studies, collaborations,\plain\cf1\f51\fs20\ql commercial prospects, internal growth, competition, intellectual property, regulatory reforms, products, objectives of management,\plain\cf1\f51\fs20\ql and compliance with NYSE MKT listing standards are forward-looking statements. Forward-looking statements may include, but\plain\cf1\f51\fs20\ql are not limited to, statements about:\par\pard\plain\cf1\f51\fs12\ql \~
\par\pard\plain
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql the initiation, scope, rate of progress, results and timing of our clinical and nonclinical studies of\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248\row}}}\pard\plain\cf1\f51\fs12\ql \~
\par\pard\plain
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql our product candidates, including vepoloxamer;\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248\row}}}\pard\plain\cf1\f51\fs12\ql \~
\par\pard\plain
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh495
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql the successful completion of our development programs and our ability to manage costs associated with clinical\plain\intbl\cf1\f51\fs20\ql and nonclinical development of our product candidates, including vepoloxamer;\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh495\row}}}\pard\plain\cf1\f51\fs12\ql \~
\par\pard\plain
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql our ability to obtain and maintain regulatory approvals of our product candidates, including vepoloxamer;\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248\row}}}\pard\plain\cf1\f51\fs12\ql \~
\par\pard\plain
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql our ability to commercialize and achieve market acceptance of our product candidates, including vepoloxamer;\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248\row}}}\pard\plain\cf1\f51\fs12\ql \~
\par\pard\plain
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh495
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql our ability to protect our intellectual property and operate our business without infringing upon the intellectual\plain\intbl\cf1\f51\fs20\ql property rights of others;\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh495\row}}}\pard\plain\cf1\f51\fs12\ql \~
\par\pard\plain
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql our estimates regarding the sufficiency of our cash resources and our need for additional funding; and\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248\row}}}\pard\plain\cf1\f51\fs12\ql \~
\par\pard\plain
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql our intended use of the net proceeds from offerings of our securities under this prospectus.\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248\row}}}\pard\plain\sb264\cf1\f51\fs20\ql The words \u8220?believe,\u8221? \u8220?anticipate,\u8221? \u8220?estimate,\u8221? \u8220?plan,\u8221?\plain\cf1\f51\fs20\ql \u8220?expect,\u8221? \u8220?intend,\u8221? \u8220?may,\u8221? \u8220?could,\u8221? \u8220?should,\u8221?\plain\cf1\f51\fs20\ql \u8220?potential,\u8221? \u8220?likely,\u8221? \u8220?projects,\u8221? \u8220?continue,\u8221? \u8220?will,\u8221? and\plain\cf1\f51\fs20\ql \u8220?would\u8221? and similar expressions are intended to identify forward-looking statements, although not all\plain\cf1\f51\fs20\ql forward-looking statements contain these identifying words. Forward-looking statements reflect our current views with respect to\plain\cf1\f51\fs20\ql future events, are based on assumptions and are subject to risks and uncertainties. We cannot guarantee that we actually will\plain\cf1\f51\fs20\ql achieve the plans, intentions or expectations expressed in our forward-looking statements and you should not place undue\plain\cf1\f51\fs20\ql reliance on these statements. There are a number of important factors that could cause our actual results to differ materially from\plain\cf1\f51\fs20\ql those indicated or implied by forward-looking statements. These important factors include those discussed under the heading\plain\cf1\f51\fs20\ql \u8220?Risk Factors\u8221? contained or incorporated in this prospectus and in the applicable prospectus supplement and any\plain\cf1\f51\fs20\ql free writing prospectus we may authorize for use in connection with a specific offering.\par\pard\plain\cf1\f51\fs16\ql \~\par\pard\plain\cf1\f51\fs20\qc 5
\page\par\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par\par\pard\plain\ul{\field{\*\fldinst HYPERLINK \\l "toc_11558912" }{\*\fldrslt\cf3\f52\fs16\b\ql Table of Contents}}\par\pard\plain\cf1\f51\fs20\ql These factors and the other cautionary statements made in this prospectus should be read as being applicable to all related\plain\cf1\f51\fs20\ql forward-looking statements whenever they appear in this prospectus. Except as required by law, we do not assume any obligation\plain\cf1\f51\fs20\ql to update any forward-looking statement. We disclaim any intention or obligation to update or revise any forward-looking\plain\cf1\f51\fs20\ql statement, whether as a result of new information, future events or otherwise.{\*\bkmkstart toc357361_5_11558912}{\*\bkmkend toc357361_5_11558912}\par\pard\plain\sb528\cf1\f51\fs20\b\qc USE OF PROCEEDS\par\pard\plain\sb264\fi462\cf1\f51\fs20\ql Except as described in any prospectus supplement and any free writing prospectus in connection with a specific offering, we\plain\cf1\f51\fs20\ql currently intend to use the net proceeds from the sale of the securities offered under this prospectus to fund continued\plain\cf1\f51\fs20\ql development of our product candidates, including clinical studies, nonclinical testing and research-related manufacturing\plain\cf1\f51\fs20\ql activities, to pursue regulatory approval for our product candidates and, potentially, to commercialize product candidates that\plain\cf1\f51\fs20\ql receive regulatory approval, and for general corporate purposes, including working capital. We may also use a portion of the net\plain\cf1\f51\fs20\ql proceeds to acquire or invest in technologies, product candidates, products and/or businesses that we believe will enhance the\plain\cf1\f51\fs20\ql value of our company, although we have no current commitments or agreements with respect to any such transactions as of the\plain\cf1\f51\fs20\ql date of this prospectus. We have not determined the amount of net proceeds to be used specifically for the foregoing purposes.\plain\cf1\f51\fs20\ql As a result, our management will have broad discretion in the allocation of the net proceeds and investors will be relying on the\plain\cf1\f51\fs20\ql judgment of our management regarding the application of the proceeds of any sale of the securities. If a material part of the net\plain\cf1\f51\fs20\ql proceeds is to be used to repay indebtedness, we will set forth the interest rate and maturity of such indebtedness in a prospectus\plain\cf1\f51\fs20\ql supplement. Pending use of the net proceeds, we intend to invest the proceeds in interest-bearing, marketable securities.{\*\bkmkstart toc357361_6_11558912}{\*\bkmkend toc357361_6_11558912}\par\pard\plain\sb528\cf1\f51\fs20\b\qc SECURITIES WE MAY OFFER\par\pard\plain\sb264\fi462\cf1\f51\fs20\ql We may offer shares of common stock, shares of preferred stock, debt securities or warrants to purchase common stock,\plain\cf1\f51\fs20\ql preferred stock or debt securities, or any combination of the foregoing, either individually or as units comprised of one or more\plain\cf1\f51\fs20\ql of the other securities. We may offer up to $150,000,000 of securities under this prospectus. If securities are offered as units, we\plain\cf1\f51\fs20\ql will describe the terms of the units in a prospectus supplement.{\*\bkmkstart toc357361_7_11558912}{\*\bkmkend toc357361_7_11558912}\par\pard\plain\sb528\cf1\f51\fs20\b\qc DESCRIPTION OF COMMON STOCK AND PREFERRED STOCK\par\pard\plain\sb264\fi462\cf1\f51\fs20\ql The following description of our common stock and preferred stock, together with any additional information we include in\plain\cf1\f51\fs20\ql any applicable prospectus supplement or any related free writing prospectus, summarizes the material terms and provisions of our\plain\cf1\f51\fs20\ql common stock and the preferred stock that we may offer under this prospectus. While the terms we have summarized below will\plain\cf1\f51\fs20\ql apply generally to any future common stock or preferred stock that we may offer, we will describe the particular terms of any\plain\cf1\f51\fs20\ql class or series of these securities in more detail in the applicable prospectus supplement. For the complete terms of our common\plain\cf1\f51\fs20\ql stock and preferred stock, please refer to our certificate of incorporation and our bylaws, each as amended to date, that are\plain\cf1\f51\fs20\ql incorporated by reference into the registration statement of which this prospectus is a part or may be incorporated by reference in\plain\cf1\f51\fs20\ql this prospectus or any applicable prospectus supplement. The terms of these securities may also be affected by the Delaware\plain\cf1\f51\fs20\ql General Corporation Law, or the DGCL. The summary below and that contained in any applicable prospectus supplement or any\plain\cf1\f51\fs20\ql related free writing prospectus are qualified in their entirety by reference to our certificate of incorporation and bylaws, as in\plain\cf1\f51\fs20\ql effect at the time of any offering of securities under this prospectus.\par\pard\plain\cf1\f51\fs16\ql \~\par\pard\plain\cf1\f51\fs20\qc 6
\page\par\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par\par\pard\plain\ul{\field{\*\fldinst HYPERLINK \\l "toc_11558912" }{\*\fldrslt\cf3\f52\fs16\b\ql Table of Contents}}\par\pard\plain\li88\cf1\f51\fs20\b\i\ql Common Stock\par\pard\plain\sb132\fi462\cf1\f51\fs20\ql As of the date of this prospectus, our certificate of incorporation authorizes us to issue 500,000,000 shares of common\plain\cf1\f51\fs20\ql stock, par value $0.001 per share, of which 159,458,376 shares were issued and outstanding as of March\~20, 2015. Additional\plain\cf1\f51\fs20\ql shares of authorized common stock may be issued, as authorized by our board of directors from time to time, without stockholder\plain\cf1\f51\fs20\ql approval, except as may be required by applicable securities exchange requirements. The holders of common stock possess\plain\cf1\f51\fs20\ql exclusive voting rights in us, except to the extent our board of directors specifies voting power with respect to any other class of\plain\cf1\f51\fs20\ql securities issued in the future. Each holder of our common stock is entitled to one vote for each share held of record on each\plain\cf1\f51\fs20\ql matter submitted to a vote of stockholders, including the election of directors. Stockholders do not have any right to cumulate\plain\cf1\f51\fs20\ql votes in the election of directors.\par\pard\plain\sb264\fi462\cf1\f51\fs20\ql Subject to preferences that may be granted to the holders of preferred stock, each holder of our common stock is entitled to\plain\cf1\f51\fs20\ql share ratably in distributions to stockholders and to receive ratably such dividends as may be declared by our board of directors\plain\cf1\f51\fs20\ql out of funds legally available therefor. In the event of our liquidation, dissolution or winding up, the holders of our common\plain\cf1\f51\fs20\ql stock will be entitled to receive, after payment of all of our debts and liabilities and of all sums to which holders of any\plain\cf1\f51\fs20\ql preferred stock may be entitled, the distribution of any of our remaining assets. Holders of our common stock have no\plain\cf1\f51\fs20\ql conversion, exchange, sinking fund or redemption rights and have no preemptive rights to subscribe for any of our securities.\par\pard\plain\sb264\fi462\cf1\f51\fs20\ql All of the outstanding shares of our common stock are fully paid and non-assessable. The shares of common stock offered\plain\cf1\f51\fs20\ql by this prospectus or upon the conversion of any preferred stock or debt securities or exercise of any warrants offered pursuant to\plain\cf1\f51\fs20\ql this prospectus, when issued and paid for, will also be, fully paid and non-assessable.\par\pard\plain\li88\sb396\cf1\f51\fs20\b\i\ql Securities Exchange Listing\par\pard\plain\sb132\fi462\cf1\f51\fs20\ql Our common stock is listed on the NYSE MKT under the symbol \u8220?MSTX.\u8221?\par\pard\plain\li88\sb396\cf1\f51\fs20\b\i\ql Transfer Agent and Registrar\par\pard\plain\sb132\fi462\cf1\f51\fs20\ql The transfer agent and registrar for our common stock is American Stock Transfer\~& Trust Company.\par\pard\plain\li88\sb396\cf1\f51\fs20\b\i\ql Preferred Stock\par\pard\plain\sb132\fi462\cf1\f51\fs20\ql As of the date of this prospectus, our certificate of incorporation authorizes us to issue 1,000,000 shares of preferred stock,\plain\cf1\f51\fs20\ql par value $0.001 per share, none of which are outstanding. Pursuant to our certificate of incorporation, our board of directors has\plain\cf1\f51\fs20\ql the authority to provide for the issuance, in one or more series, of our authorized preferred stock and to fix or alter the rights,\plain\cf1\f51\fs20\ql preferences, privileges and restrictions granted to or imposed upon any series of our preferred stock. The rights, privileges,\plain\cf1\f51\fs20\ql preferences and restrictions of any such series of our preferred stock may be subordinated to, pari passu with (including, without\plain\cf1\f51\fs20\ql limitation, inclusion in provisions with respect to liquidation and acquisition preferences, redemption or approval of matters by\plain\cf1\f51\fs20\ql vote or written consent), or senior to any of those of any present or future class or series of preferred stock or common stock.\plain\cf1\f51\fs20\ql Our board of directors is also expressly authorized to increase or decrease the number of shares of any series prior or subsequent\plain\cf1\f51\fs20\ql to the issue of that series, but not below the number of shares of such series then outstanding. The issuance of preferred stock\plain\cf1\f51\fs20\ql may have the effect of decreasing the market price of our common stock and may adversely affect the voting power of holders of\plain\cf1\f51\fs20\ql our common stock and reduce the likelihood that holders of our common stock will receive dividend payments and payments\plain\cf1\f51\fs20\ql upon liquidation.\par\pard\plain\sb264\fi462\cf1\f51\fs20\ql The particular terms of each class or series of preferred stock that we may offer under this prospectus, including redemption\plain\cf1\f51\fs20\ql privileges, liquidation preferences, voting rights, dividend rights and/or conversion rights, will be more fully described in the\plain\cf1\f51\fs20\ql applicable prospectus supplement relating to the preferred stock offered\par\pard\plain\cf1\f51\fs16\ql \~\par\pard\plain\cf1\f51\fs20\qc 7
\page\par\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par\par\pard\plain\ul{\field{\*\fldinst HYPERLINK \\l "toc_11558912" }{\*\fldrslt\cf3\f52\fs16\b\ql Table of Contents}}\par\pard\plain\cf1\f51\fs20\ql thereby. The rights, preferences, privileges and restrictions of any series of preferred stock that we may offer under this\plain\cf1\f51\fs20\ql prospectus will be set forth in the certificate of designation relating to that series. We will file as an exhibit to the registration\plain\cf1\f51\fs20\ql statement of which this prospectus is a part, or will incorporate by reference from another report we file with the SEC, the form\plain\cf1\f51\fs20\ql of any certificate of designation that describes the terms of the series of preferred stock we may offer before the issuance of the\plain\cf1\f51\fs20\ql related series of preferred stock. The applicable prospectus supplement will specify the terms of the series of preferred stock we\plain\cf1\f51\fs20\ql may offer, including, but not limited to:\par\pard\plain\cf1\f51\fs12\ql \~
\par\pard\plain
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\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql the distinctive designation and the maximum number of shares in the series;\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248\row}}}\pard\plain\cf1\f51\fs12\ql \~
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{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql the number of shares we are offering and purchase price per share;\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248\row}}}\pard\plain\cf1\f51\fs12\ql \~
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{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql the liquidation preference, if any;\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248\row}}}\pard\plain\cf1\f51\fs12\ql \~
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{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql the terms on which dividends, if any, will be paid;\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248\row}}}\pard\plain\cf1\f51\fs12\ql \~
\par\pard\plain
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql the voting rights, if any, of the shares of the series;\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248\row}}}\pard\plain\cf1\f51\fs12\ql \~
\par\pard\plain
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh495
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql the terms and conditions, if any, on which the shares of the series shall be convertible into, or exchangeable for,\plain\intbl\cf1\f51\fs20\ql shares of any other class or classes of capital stock;\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh495\row}}}\pard\plain\cf1\f51\fs12\ql \~
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{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql the terms on which the shares may be redeemed, if at all;\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248\row}}}\pard\plain\cf1\f51\fs12\ql \~
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{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql any listing of the preferred stock on any securities exchange or market;\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248\row}}}\pard\plain\cf1\f51\fs12\ql \~
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{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh495
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql a discussion of any material or special United States federal income tax considerations applicable to the preferred\plain\intbl\cf1\f51\fs20\ql stock; and\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh495\row}}}\pard\plain\cf1\f51\fs12\ql \~
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{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh495
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql any or all other preferences, rights, restrictions, including restrictions on transferability, and qualifications of\plain\intbl\cf1\f51\fs20\ql shares of the series.\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh495\row}}}\pard\plain\sb264\fi462\cf1\f51\fs20\ql The description of preferred stock above and the description of the terms of a particular series of preferred stock in any\plain\cf1\f51\fs20\ql applicable prospectus supplement are not complete. You should refer to the applicable certificate of designation for complete\plain\cf1\f51\fs20\ql information.\par\pard\plain\sb264\fi462\cf1\f51\fs20\ql The DGCL provides that the holders of preferred stock will have the right to vote separately as a class on any proposal\plain\cf1\f51\fs20\ql involving fundamental changes in the rights of holders of that preferred stock. This right is in addition to any voting rights that\plain\cf1\f51\fs20\ql may be provided for in the applicable certificate of designation.\par\pard\plain\li88\sb396\cf1\f51\fs20\b\i\ql Anti-Takeover Effects of Provisions of our Charter Documents and Delaware Law\par\pard\plain\sb132\fi462\cf1\f51\fs20\ql Provisions of the DGCL, our certificate of incorporation and our bylaws could make it more difficult to acquire us by\plain\cf1\f51\fs20\ql means of a tender offer, a proxy contest or otherwise, or to remove incumbent officers and directors. These provisions,\plain\cf1\f51\fs20\ql summarized below, are expected to discourage certain types of coercive takeover practices and takeover bids that our board of\plain\cf1\f51\fs20\ql directors may consider inadequate and to encourage persons seeking to acquire control of us to first negotiate with our board of\plain\cf1\f51\fs20\ql directors. We believe that the benefits of increased protection of our ability to negotiate with the proponent of an unfriendly or\plain\cf1\f51\fs20\ql unsolicited proposal to acquire or restructure us outweigh the disadvantages of discouraging takeover or acquisition proposals\plain\cf1\f51\fs20\ql because, among other things, negotiation of these proposals could result in an improvement of their terms. This summary does\plain\cf1\f51\fs20\ql not purport to be complete and is qualified in its entirety by reference to the DGCL and our certificate of incorporation and\plain\cf1\f51\fs20\ql bylaws.\par\pard\plain\sb396\fi462\cf1\f51\fs20\ul\ql Certificate of Incorporation and Bylaws\par\pard\plain\sb132\fi462\cf1\f51\fs20\i\ql Preferred Stock\plain\cf1\f51\fs20\ql . Under our certificate of incorporation, our board of directors has the power to authorize the issuance of up\plain\cf1\f51\fs20\ql to 1,000,000 shares of preferred stock, all of which are currently undesignated, and to determine\par\pard\plain\cf1\f51\fs16\ql \~\par\pard\plain\cf1\f51\fs20\qc 8
\page\par\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par\par\pard\plain\ul{\field{\*\fldinst HYPERLINK \\l "toc_11558912" }{\*\fldrslt\cf3\f52\fs16\b\ql Table of Contents}}\par\pard\plain\cf1\f51\fs20\ql the price, rights, preferences, privileges and restrictions, including voting rights, of those shares without further vote or action by\plain\cf1\f51\fs20\ql our stockholders. The issuance of preferred stock may:\par\pard\plain\cf1\f51\fs12\ql \~
\par\pard\plain
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql delay, defer or prevent a change in control;\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248\row}}}\pard\plain\cf1\f51\fs12\ql \~
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{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql discourage bids for our common stock at a premium over the market price of our common stock;\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248\row}}}\pard\plain\cf1\f51\fs12\ql \~
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{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql adversely affect the voting and other rights of the holders of our common stock; and\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248\row}}}\pard\plain\cf1\f51\fs12\ql \~
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{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh495
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql discourage acquisition proposals or tender offers for our shares and, as a consequence, inhibit fluctuations in the\plain\intbl\cf1\f51\fs20\ql market price of our shares that could result from actual or rumored takeover attempts.\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh495\row}}}\pard\plain\sb264\fi462\cf1\f51\fs20\i\ql Advance Notice Requirement\plain\cf1\f51\fs20\ql . Stockholder nominations of individuals for election to our board of directors and stockholder\plain\cf1\f51\fs20\ql proposals of other matters to be brought before an annual meeting of our stockholders must comply with the advance notice\plain\cf1\f51\fs20\ql procedures set forth in our bylaws. Generally, to be timely, such notice must be received at our principal executive offices no\plain\cf1\f51\fs20\ql later than the date specified in our proxy statement released to stockholders in connection with the preceding year\u8217?s annual\plain\cf1\f51\fs20\ql meeting of stockholders, which date shall be not earlier than the 120th day, nor later than the close of business on the 90th day,\plain\cf1\f51\fs20\ql prior to the first anniversary of the date of the preceding year\u8217?s annual meeting of stockholders.\par\pard\plain\sb264\fi462\cf1\f51\fs20\i\ql Special Meeting Requirements\plain\cf1\f51\fs20\ql . Our bylaws provide that special meetings of our stockholders may be called only at the\plain\cf1\f51\fs20\ql request of our board of directors, president (unless there is a chief executive officer who is not the president, in which case a\plain\cf1\f51\fs20\ql special meeting may be called at any time by the chief executive officer and not the president) or chair of the board of directors.\plain\cf1\f51\fs20\ql Only such business shall be considered at a special meeting as shall have been stated in the notice for such meeting.\par\pard\plain\sb264\fi462\cf1\f51\fs20\i\ql No Cumulative Voting\plain\cf1\f51\fs20\ql . Our certificate of incorporation does not include a provision for cumulative voting for directors.\par\pard\plain\sb264\fi462\cf1\f51\fs20\i\ql Indemnification\plain\cf1\f51\fs20\ql . Our certificate of incorporation and bylaws provide that we will indemnify our officers and directors\plain\cf1\f51\fs20\ql against losses as they incur in investigations and legal proceedings resulting from their services to us, which may include service\plain\cf1\f51\fs20\ql in connection with takeover defense measures.\par\pard\plain\sb264\fi462\cf1\f51\fs20\i\ql Removal of Directors\plain\cf1\f51\fs20\ql . Our bylaws provide that the affirmative vote of the holders of at least 75% of our voting stock then\plain\cf1\f51\fs20\ql outstanding is required to remove our directors, either with or without cause.\par\pard\plain\sb264\fi462\cf1\f51\fs20\i\ql Authorized but Unissued Shares\plain\cf1\f51\fs20\ql . Our authorized but unissued shares of common stock and preferred stock will be available\plain\cf1\f51\fs20\ql for future issuance without stockholder approval. We may use additional shares for a variety of purposes, including future public\plain\cf1\f51\fs20\ql offerings to raise additional capital, to fund acquisitions and as employee compensation. The existence of authorized but unissued\plain\cf1\f51\fs20\ql shares of common stock and preferred stock could render more difficult or discourage an attempt to obtain control of us by\plain\cf1\f51\fs20\ql means of a proxy contest, tender offer, merger or otherwise.\par\pard\plain\sb396\fi462\cf1\f51\fs20\ul\ql Delaware Anti-Takeover Statute\par\pard\plain\sb132\fi462\cf1\f51\fs20\ql We are subject to Section\~203 of the DGCL, an anti-takeover law. In general, Section\~203 prohibits, with some exceptions,\plain\cf1\f51\fs20\ql a publicly held Delaware corporation from engaging in a \u8220?business combination\u8221? with any \u8220?interested\plain\cf1\f51\fs20\ql stockholder\u8221? for a period of three years following the date that stockholder became an interested stockholder, unless:\par\pard\plain\cf1\f51\fs12\ql \~
\par\pard\plain
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh495
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql prior to that date, the board of directors of the corporation approved either the business combination or the\plain\intbl\cf1\f51\fs20\ql transaction that resulted in the stockholder becoming an interested stockholder;\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh495\row}}}\pard\plain\cf1\f51\fs16\ql \~\par\pard\plain\cf1\f51\fs20\qc 9
\page\par\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par\par\pard\plain\ul{\field{\*\fldinst HYPERLINK \\l "toc_11558912" }{\*\fldrslt\cf3\f52\fs16\b\ql Table of Contents}}
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{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh1485
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql upon consummation of the transaction that resulted in the stockholder becoming an interested stockholder, the\plain\intbl\cf1\f51\fs20\ql interested stockholder owned at least 85% of the voting stock of the corporation outstanding at the time the\plain\intbl\cf1\f51\fs20\ql transaction commenced, excluding for purposes of determining the number of shares of voting stock outstanding\plain\intbl\cf1\f51\fs20\ql (but not the voting stock owned by the interested stockholder) those shares owned by persons who are directors\plain\intbl\cf1\f51\fs20\ql and officers and by excluding employee stock plans in which employee participants do not have the right to\plain\intbl\cf1\f51\fs20\ql determine whether shares held subject to the plan will be tendered in a tender or exchange offer; or\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh1485\row}}}\pard\plain\cf1\f51\fs12\ql \~
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{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh742
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql on or subsequent to that date, the business combination is approved by the board of directors of the corporation\plain\intbl\cf1\f51\fs20\ql and authorized at an annual or special meeting of stockholders, and not by written consent, by the affirmative\plain\intbl\cf1\f51\fs20\ql vote of at least 66-2/3% of the outstanding voting stock that is not owned by the interested stockholder.\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh742\row}}}\pard\plain\sb264\fi462\cf1\f51\fs20\ql Section\~203 defines \u8220?business combination\u8221? to include any of the following:\par\pard\plain\cf1\f51\fs12\ql \~
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{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql any merger or consolidation involving the corporation and the interested stockholder;\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248\row}}}\pard\plain\cf1\f51\fs12\ql \~
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{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh495
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql any sale, transfer, pledge or other disposition of 10% or more of the assets of the corporation involving the\plain\intbl\cf1\f51\fs20\ql interested stockholder;\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh495\row}}}\pard\plain\cf1\f51\fs12\ql \~
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\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql subject to certain exceptions, any transaction that results in the issuance or transfer by the corporation of any\plain\intbl\cf1\f51\fs20\ql stock of the corporation to the interested stockholder;\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh495\row}}}\pard\plain\cf1\f51\fs12\ql \~
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{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh495
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql any transaction involving the corporation that has the effect of increasing the proportionate share of the stock of\plain\intbl\cf1\f51\fs20\ql any class or series of the corporation beneficially owned by the interested stockholder; or\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh495\row}}}\pard\plain\cf1\f51\fs12\ql \~
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{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh495
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql the receipt by the interested stockholder of the benefit of any loans, advances, guarantees, pledges or other\plain\intbl\cf1\f51\fs20\ql financial benefits provided by or through the corporation.\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh495\row}}}\pard\plain\sb264\fi462\cf1\f51\fs20\ql In general, Section\~203 defines an \u8220?interested stockholder\u8221? as any person who, together with the\plain\cf1\f51\fs20\ql person\u8217?s affiliates and associates, beneficially owns, or within three years prior to the determination of interested\plain\cf1\f51\fs20\ql stockholder status did beneficially own, 15% or more of the outstanding voting stock of the corporation.\par\pard\plain\sb264\fi462\cf1\f51\fs20\ql The above provisions may deter a hostile takeover or delay a change in control of management or us.{\*\bkmkstart toc357361_8_11558912}{\*\bkmkend toc357361_8_11558912}\par\pard\plain\sb528\cf1\f51\fs20\b\qc DESCRIPTION OF DEBT SECURITIES\par\pard\plain\sb264\fi462\cf1\f51\fs20\ql We may issue debt securities, in one or more series, as either senior or subordinated debt or as senior or subordinated\plain\cf1\f51\fs20\ql convertible debt. The following description, together with the additional information we include in any applicable prospectus\plain\cf1\f51\fs20\ql supplements or free writing prospectuses, summarizes the material terms and provisions of the debt securities that we may offer\plain\cf1\f51\fs20\ql under this prospectus. While the terms we have summarized below will apply generally to any future debt securities we may\plain\cf1\f51\fs20\ql offer under this prospectus, we will describe the particular terms of any debt securities that we may offer in more detail in the\plain\cf1\f51\fs20\ql applicable prospectus supplement or free writing prospectus. The terms of any debt securities we offer under a prospectus\plain\cf1\f51\fs20\ql supplement may differ from the terms we describe below. However, no prospectus supplement shall fundamentally change the\plain\cf1\f51\fs20\ql terms that are set forth in this prospectus or offer a security that is not registered and described in this prospectus at the time of\plain\cf1\f51\fs20\ql its effectiveness. As of March\~24, 2015, we have no outstanding registered debt securities. Unless the context requires otherwise,\plain\cf1\f51\fs20\ql whenever we refer to the \u8220?indentures,\u8221? we also are referring to any supplemental indentures that specify the terms\plain\cf1\f51\fs20\ql of a particular series of debt securities.\par\pard\plain\sb264\fi462\cf1\f51\fs20\ql We will issue any senior debt securities under the senior indenture that we will enter into with the trustee named in the\plain\cf1\f51\fs20\ql senior indenture. We will issue any subordinated debt securities under the subordinated indenture and any supplemental\plain\cf1\f51\fs20\ql indentures that we will enter into with the trustee named in the subordinated indenture. We have filed forms of these documents\plain\cf1\f51\fs20\ql as exhibits to the registration statement, of which this prospectus is a part,\par\pard\plain\cf1\f51\fs16\ql \~\par\pard\plain\cf1\f51\fs20\qc 10
\page\par\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par\par\pard\plain\ul{\field{\*\fldinst HYPERLINK \\l "toc_11558912" }{\*\fldrslt\cf3\f52\fs16\b\ql Table of Contents}}\par\pard\plain\cf1\f51\fs20\ql and supplemental indentures and forms of debt securities containing the terms of the debt securities being offered will be filed as\plain\cf1\f51\fs20\ql exhibits to the registration statement of which this prospectus is a part or will be incorporated by reference from reports that we\plain\cf1\f51\fs20\ql file with the SEC.\par\pard\plain\sb264\fi462\cf1\f51\fs20\ql The indentures will be qualified under the Trust Indenture Act of 1939, as amended (the \u8220?Trust Indenture\plain\cf1\f51\fs20\ql Act\u8221?). We use the term \u8220?trustee\u8221? to refer to either the trustee under the senior indenture or the trustee under\plain\cf1\f51\fs20\ql the subordinated indenture, as applicable.\par\pard\plain\sb264\fi462\cf1\f51\fs20\ql The following summaries of material provisions of the senior debt securities, the subordinated debt securities and the\plain\cf1\f51\fs20\ql indentures are subject to, and qualified in their entirety by reference to, all of the provisions of the indenture and any\plain\cf1\f51\fs20\ql supplemental indentures applicable to a particular series of debt securities. We urge you to read the applicable prospectus\plain\cf1\f51\fs20\ql supplements and any related free writing prospectuses related to the debt securities that we may offer under this prospectus, as\plain\cf1\f51\fs20\ql well as the complete indentures that contains the terms of the debt securities. Except as we may otherwise indicate, the terms of\plain\cf1\f51\fs20\ql the senior indenture and the subordinated indenture are identical.\par\pard\plain\li88\sb396\cf1\f51\fs20\b\i\ql General\par\pard\plain\sb132\fi462\cf1\f51\fs20\ql The terms of each series of debt securities will be established by or pursuant to a resolution of our board of directors and\plain\cf1\f51\fs20\ql set forth or determined in the manner provided in an officers\u8217? certificate or by a supplemental indenture. Debt securities\plain\cf1\f51\fs20\ql may be issued in separate series without limitation as to aggregate principal amount. We may specify a maximum aggregate\plain\cf1\f51\fs20\ql principal amount for the debt securities of any series. We will describe in the applicable prospectus supplement the terms of the\plain\cf1\f51\fs20\ql series of debt securities being offered, including:\par\pard\plain\cf1\f51\fs12\ql \~
\par\pard\plain
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql the title;\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248\row}}}\pard\plain\cf1\f51\fs12\ql \~
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{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql the principal amount being offered, and if a series, the total amount authorized and the total amount outstanding;\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248\row}}}\pard\plain\cf1\f51\fs12\ql \~
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{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql any limit on the amount that may be issued;\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248\row}}}\pard\plain\cf1\f51\fs12\ql \~
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{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh495
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql whether or not we will issue the series of debt securities in global form, and, if so, the terms and who the\plain\intbl\cf1\f51\fs20\ql depositary will be;\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh495\row}}}\pard\plain\cf1\f51\fs12\ql \~
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\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql the maturity date;\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248\row}}}\pard\plain\cf1\f51\fs12\ql \~
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\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql whether and under what circumstances, if any, we will pay additional amounts on any debt securities held by a\plain\intbl\cf1\f51\fs20\ql person who is not a United States person for tax purposes, and whether we can redeem the debt securities if we\plain\intbl\cf1\f51\fs20\ql have to pay such additional amounts;\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh742\row}}}\pard\plain\cf1\f51\fs12\ql \~
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{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh742
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql the annual interest rate, which may be fixed or variable, or the method for determining the rate and the date\plain\intbl\cf1\f51\fs20\ql interest will begin to accrue, the dates interest will be payable and the regular record dates for interest payment\plain\intbl\cf1\f51\fs20\ql dates or the method for determining such dates;\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh742\row}}}\pard\plain\cf1\f51\fs12\ql \~
\par\pard\plain
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql whether or not the debt securities will be secured or unsecured, and the terms of any secured debt;\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248\row}}}\pard\plain\cf1\f51\fs12\ql \~
\par\pard\plain
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql the terms of the subordination of any series of subordinated debt;\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248\row}}}\pard\plain\cf1\f51\fs12\ql \~
\par\pard\plain
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql the place where payments will be made;\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248\row}}}\pard\plain\cf1\f51\fs12\ql \~
\par\pard\plain
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql restrictions on transfer, sale or other assignment, if any;\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248\row}}}\pard\plain\cf1\f51\fs12\ql \~
\par\pard\plain
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql our right, if any, to defer payment of interest and the maximum length of any such deferral period;\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248\row}}}\pard\plain\cf1\f51\fs12\ql \~
\par\pard\plain
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh495
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql the date, if any, after which, and the price at which, we may, at our option, redeem the series of debt securities\plain\intbl\cf1\f51\fs20\ql pursuant to any optional or provisional redemption provisions and the terms of those redemption provisions;\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh495\row}}}\pard\plain\cf1\f51\fs16\ql \~\par\pard\plain\cf1\f51\fs20\qc 11
\page\par\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par\par\pard\plain\ul{\field{\*\fldinst HYPERLINK \\l "toc_11558912" }{\*\fldrslt\cf3\f52\fs16\b\ql Table of Contents}}
\par\pard\plain
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh742
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql provisions for a sinking fund purchase or other analogous fund, if any, including the date, if any, on which, and\plain\intbl\cf1\f51\fs20\ql the price at which we are obligated, pursuant thereto or otherwise, to redeem, or at the holder\u8217?s option, to\plain\intbl\cf1\f51\fs20\ql purchase, the series of debt securities and the currency or currency unit in which the debt securities are payable;\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh742\row}}}\pard\plain\cf1\f51\fs12\ql \~
\par\pard\plain
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql whether the indenture will restrict our ability or the ability of our subsidiaries to:\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248\row}}}\pard\plain\cf1\f51\fs12\ql \~
\par\pard\plain
{\trowd\clvertalc\cellx972\cellx1636\cellx1744\cellx10800\trrh248
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql incur additional indebtedness;\cell{
{\trowd\clvertalc\cellx972\cellx1636\cellx1744\cellx10800\trrh248\row}}}\pard\plain\cf1\f51\fs12\ql \~
\par\pard\plain
{\trowd\clvertalc\cellx972\cellx1636\cellx1744\cellx10800\trrh248
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql issue additional securities;\cell{
{\trowd\clvertalc\cellx972\cellx1636\cellx1744\cellx10800\trrh248\row}}}\pard\plain\cf1\f51\fs12\ql \~
\par\pard\plain
{\trowd\clvertalc\cellx972\cellx1636\cellx1744\cellx10800\trrh248
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql create liens;\cell{
{\trowd\clvertalc\cellx972\cellx1636\cellx1744\cellx10800\trrh248\row}}}\pard\plain\cf1\f51\fs12\ql \~
\par\pard\plain
{\trowd\clvertalc\cellx972\cellx1636\cellx1744\cellx10800\trrh248
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql pay dividends or make distributions in respect of our capital stock or the capital stock of our subsidiaries;\cell{
{\trowd\clvertalc\cellx972\cellx1636\cellx1744\cellx10800\trrh248\row}}}\pard\plain\cf1\f51\fs12\ql \~
\par\pard\plain
{\trowd\clvertalc\cellx972\cellx1636\cellx1744\cellx10800\trrh248
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql redeem capital stock;\cell{
{\trowd\clvertalc\cellx972\cellx1636\cellx1744\cellx10800\trrh248\row}}}\pard\plain\cf1\f51\fs12\ql \~
\par\pard\plain
{\trowd\clvertalc\cellx972\cellx1636\cellx1744\cellx10800\trrh248
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql place restrictions on our subsidiaries\u8217? ability to pay dividends, make distributions or transfer assets;\cell{
{\trowd\clvertalc\cellx972\cellx1636\cellx1744\cellx10800\trrh248\row}}}\pard\plain\cf1\f51\fs12\ql \~
\par\pard\plain
{\trowd\clvertalc\cellx972\cellx1636\cellx1744\cellx10800\trrh248
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql make investments or other restricted payments;\cell{
{\trowd\clvertalc\cellx972\cellx1636\cellx1744\cellx10800\trrh248\row}}}\pard\plain\cf1\f51\fs12\ql \~
\par\pard\plain
{\trowd\clvertalc\cellx972\cellx1636\cellx1744\cellx10800\trrh248
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql sell or otherwise dispose of assets;\cell{
{\trowd\clvertalc\cellx972\cellx1636\cellx1744\cellx10800\trrh248\row}}}\pard\plain\cf1\f51\fs12\ql \~
\par\pard\plain
{\trowd\clvertalc\cellx972\cellx1636\cellx1744\cellx10800\trrh248
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql enter into sale-leaseback transactions;\cell{
{\trowd\clvertalc\cellx972\cellx1636\cellx1744\cellx10800\trrh248\row}}}\pard\plain\cf1\f51\fs12\ql \~
\par\pard\plain
{\trowd\clvertalc\cellx972\cellx1636\cellx1744\cellx10800\trrh248
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql engage in transactions with stockholders or affiliates;\cell{
{\trowd\clvertalc\cellx972\cellx1636\cellx1744\cellx10800\trrh248\row}}}\pard\plain\cf1\f51\fs12\ql \~
\par\pard\plain
{\trowd\clvertalc\cellx972\cellx1636\cellx1744\cellx10800\trrh248
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql issue or sell stock of our subsidiaries; or\cell{
{\trowd\clvertalc\cellx972\cellx1636\cellx1744\cellx10800\trrh248\row}}}\pard\plain\cf1\f51\fs12\ql \~
\par\pard\plain
{\trowd\clvertalc\cellx972\cellx1636\cellx1744\cellx10800\trrh248
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql effect a consolidation or merger;\cell{
{\trowd\clvertalc\cellx972\cellx1636\cellx1744\cellx10800\trrh248\row}}}\pard\plain\cf1\f51\fs12\ql \~
\par\pard\plain
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh495
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql whether the indenture will require us to maintain any interest coverage, fixed charge, cash flow-based,\plain\intbl\cf1\f51\fs20\ql asset-based or other financial ratios;\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh495\row}}}\pard\plain\cf1\f51\fs12\ql \~
\par\pard\plain
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh495
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql a discussion of certain material or special United States federal income tax considerations applicable to the debt\plain\intbl\cf1\f51\fs20\ql securities;\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh495\row}}}\pard\plain\cf1\f51\fs12\ql \~
\par\pard\plain
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql information describing any book-entry features;\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248\row}}}\pard\plain\cf1\f51\fs12\ql \~
\par\pard\plain
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql the applicability of the provisions in the indenture on discharge;\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248\row}}}\pard\plain\cf1\f51\fs12\ql \~
\par\pard\plain
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh742
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql whether the debt securities are to be offered at a price such that they will be deemed to be offered at an\plain\intbl\cf1\f51\fs20\ql \u8220?original issue discount\u8221? as defined in paragraph (a)\~of Section\~1273 of the Internal Revenue Code\plain\intbl\cf1\f51\fs20\ql of 1986, as amended;\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh742\row}}}\pard\plain\cf1\f51\fs12\ql \~
\par\pard\plain
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh495
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql the denominations in which we will issue the series of debt securities, if other than denominations of $1,000 and\plain\intbl\cf1\f51\fs20\ql any integral multiple thereof;\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh495\row}}}\pard\plain\cf1\f51\fs12\ql \~
\par\pard\plain
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh495
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql the currency of payment of debt securities if other than U.S. dollars and the manner of determining the equivalent\plain\intbl\cf1\f51\fs20\ql amount in U.S. dollars; and\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh495\row}}}\pard\plain\cf1\f51\fs12\ql \~
\par\pard\plain
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh0
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql any other specific terms, preferences, rights or limitations of, or restrictions on, the debt securities, including any\plain\intbl\cf1\f51\fs20\ql additional events of default or covenants provided with respect to the debt securities, and any terms that may be\plain\intbl\cf1\f51\fs20\ql required by us or advisable under applicable laws or regulations.\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh0\row}}}\pard\plain\li88\sb396\cf1\f51\fs20\b\i\ql Conversion or Exchange Rights\par\pard\plain\sb132\fi462\cf1\f51\fs20\ql We will set forth in the applicable prospectus supplement the terms under which a series of debt securities may be\plain\cf1\f51\fs20\ql convertible into or exchangeable for our common stock, our preferred stock or other securities (including securities of a third\plain\cf1\f51\fs20\ql party). We will include provisions as to whether conversion or exchange is mandatory, at the\par\pard\plain\cf1\f51\fs16\ql \~\par\pard\plain\cf1\f51\fs20\qc 12
\page\par\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par\par\pard\plain\ul{\field{\*\fldinst HYPERLINK \\l "toc_11558912" }{\*\fldrslt\cf3\f52\fs16\b\ql Table of Contents}}\par\pard\plain\cf1\f51\fs20\ql option of the holder or at our option. We may include provisions pursuant to which the number of shares of our common stock,\plain\cf1\f51\fs20\ql our preferred stock or other securities (including securities of a third party) that the holders of the series of debt securities receive\plain\cf1\f51\fs20\ql would be subject to adjustment.\par\pard\plain\li88\sb396\cf1\f51\fs20\b\i\ql Consolidation, Merger or Sale\par\pard\plain\sb132\fi462\cf1\f51\fs20\ql Unless we provide otherwise in the prospectus supplement applicable to a particular series of debt securities, the indentures\plain\cf1\f51\fs20\ql will not contain any covenant that restricts our ability to merge or consolidate, or sell, convey, transfer or otherwise dispose of all\plain\cf1\f51\fs20\ql or substantially all of our assets. However, any successor to or acquirer of such assets must assume all of our obligations under\plain\cf1\f51\fs20\ql the indentures or the debt securities, as appropriate. If the debt securities are convertible into or exchangeable for our other\plain\cf1\f51\fs20\ql securities or securities of other entities, the person with whom we consolidate or merge or to whom we sell all of our property\plain\cf1\f51\fs20\ql must make provisions for the conversion of the debt securities into securities that the holders of the debt securities would have\plain\cf1\f51\fs20\ql received if they had converted the debt securities before the consolidation, merger or sale.\par\pard\plain\li88\sb396\cf1\f51\fs20\b\i\ql Events of Default under the Indenture\par\pard\plain\sb132\fi462\cf1\f51\fs20\ql Unless we provide otherwise in the prospectus supplement applicable to a particular series of debt securities, the following\plain\cf1\f51\fs20\ql are events of default under the indentures with respect to any series of debt securities that we may issue:\par\pard\plain\cf1\f51\fs12\ql \~
\par\pard\plain
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh495
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql if we fail to pay interest when due and payable and our failure continues for 90 days and the time for payment\plain\intbl\cf1\f51\fs20\ql has not been extended;\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh495\row}}}\pard\plain\cf1\f51\fs12\ql \~
\par\pard\plain
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh495
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql if we fail to pay the principal, premium or sinking fund payment, if any, when due and payable at maturity, upon\plain\intbl\cf1\f51\fs20\ql redemption or repurchase or otherwise, and the time for payment has not been extended;\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh495\row}}}\pard\plain\cf1\f51\fs12\ql \~
\par\pard\plain
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh990
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql if we fail to observe or perform any other covenant contained in the debt securities or the indentures, other than a\plain\intbl\cf1\f51\fs20\ql covenant specifically relating to another series of debt securities, and our failure continues for 90 days after we\plain\intbl\cf1\f51\fs20\ql receive notice from the trustee or we and the trustee receive notice from the holders of at least 25% in aggregate\plain\intbl\cf1\f51\fs20\ql principal amount of the outstanding debt securities of the applicable series; and\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh990\row}}}\pard\plain\cf1\f51\fs12\ql \~
\par\pard\plain
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql if specified events of bankruptcy, insolvency or reorganization occur.\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248\row}}}\pard\plain\sb264\fi462\cf1\f51\fs20\ql We will describe in each applicable prospectus supplement any additional events of default relating to the relevant series of\plain\cf1\f51\fs20\ql debt securities.\par\pard\plain\sb264\fi462\cf1\f51\fs20\ql If an event of default with respect to debt securities of any series occurs and is continuing, other than an event of default\plain\cf1\f51\fs20\ql specified in the last bullet point above, the trustee or the holders of at least 25% in aggregate principal amount of the outstanding\plain\cf1\f51\fs20\ql debt securities of that series, by notice to us in writing, and to the trustee if notice is given by such holders, may declare the\plain\cf1\f51\fs20\ql unpaid principal, premium, if any, and accrued interest, if any, due and payable immediately. If an event of default arises due to\plain\cf1\f51\fs20\ql the occurrence of certain specified bankruptcy, insolvency or reorganization events, the unpaid principal, premium, if any, and\plain\cf1\f51\fs20\ql accrued interest, if any, of each issue of debt securities then outstanding shall be due and payable without any notice or other\plain\cf1\f51\fs20\ql action on the part of the trustee or any holder.\par\pard\plain\sb264\fi462\cf1\f51\fs20\ql The holders of a majority in principal amount of the outstanding debt securities of an affected series may waive any default\plain\cf1\f51\fs20\ql or event of default with respect to the series and its consequences, except defaults or events of default regarding payment of\plain\cf1\f51\fs20\ql principal, premium, if any, or interest, unless we have cured the default or event of default in accordance with the indenture. Any\plain\cf1\f51\fs20\ql waiver shall cure the default or event of default.\par\pard\plain\sb264\fi462\cf1\f51\fs20\ql Subject to the terms of the indentures, if an event of default under an indenture shall occur and be continuing, the trustee\plain\cf1\f51\fs20\ql will be under no obligation to exercise any of its rights or powers under such indenture at\par\pard\plain\cf1\f51\fs16\ql \~\par\pard\plain\cf1\f51\fs20\qc 13
\page\par\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par\par\pard\plain\ul{\field{\*\fldinst HYPERLINK \\l "toc_11558912" }{\*\fldrslt\cf3\f52\fs16\b\ql Table of Contents}}\par\pard\plain\cf1\f51\fs20\ql the request or direction of any of the holders of the applicable series of debt securities, unless such holders have offered the\plain\cf1\f51\fs20\ql trustee reasonable indemnity or security satisfactory to it against any loss, liability or expense. The holders of a majority in\plain\cf1\f51\fs20\ql principal amount of the outstanding debt securities of any series will have the right to direct the time, method and place of\plain\cf1\f51\fs20\ql conducting any proceeding for any remedy available to the trustee, or exercising any trust or power conferred on the trustee, with\plain\cf1\f51\fs20\ql respect to the debt securities of that series, provided that:\par\pard\plain\cf1\f51\fs12\ql \~
\par\pard\plain
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql the direction so given by the holder is not in conflict with any law or the applicable indenture; and\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248\row}}}\pard\plain\cf1\f51\fs12\ql \~
\par\pard\plain
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh495
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql subject to its duties under the Trust Indenture Act, the trustee need not take any action that might involve it in\plain\intbl\cf1\f51\fs20\ql personal liability or might be unduly prejudicial to the holders not involved in the proceeding.\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh495\row}}}\pard\plain\sb264\fi462\cf1\f51\fs20\ql The indentures provide that if an event of default has occurred and is continuing, the trustee will be required in the exercise\plain\cf1\f51\fs20\ql of its powers to use the degree of care that a prudent person would use in the conduct of its own affairs. The trustee, however,\plain\cf1\f51\fs20\ql may refuse to follow any direction that conflicts with law or the indenture, or that the trustee determines is unduly prejudicial to\plain\cf1\f51\fs20\ql the rights of any other holder of the relevant series of debt securities, or that would involve the trustee in personal liability. Prior\plain\cf1\f51\fs20\ql to taking any action under the indentures, the trustee will be entitled to indemnification against all costs, expenses and liabilities\plain\cf1\f51\fs20\ql that would be incurred by taking or not taking such action.\par\pard\plain\sb264\fi462\cf1\f51\fs20\ql A holder of the debt securities of any series will have the right to institute a proceeding under the indentures or to appoint a\plain\cf1\f51\fs20\ql receiver or trustee, or to seek other remedies only if:\par\pard\plain\cf1\f51\fs12\ql \~
\par\pard\plain
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql the holder has given written notice to the trustee of a continuing event of default with respect to that series;\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248\row}}}\pard\plain\cf1\f51\fs12\ql \~
\par\pard\plain
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh990
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql the holders of at least 25% in aggregate principal amount of the outstanding debt securities of that series have\plain\intbl\cf1\f51\fs20\ql made a written request and such holders have offered reasonable indemnity to the trustee or security satisfactory\plain\intbl\cf1\f51\fs20\ql to it against any loss, liability or expense or to be incurred in compliance with instituting the proceeding as\plain\intbl\cf1\f51\fs20\ql trustee; and\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh990\row}}}\pard\plain\cf1\f51\fs12\ql \~
\par\pard\plain
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh742
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql the trustee does not institute the proceeding, and does not receive from the holders of a majority in aggregate\plain\intbl\cf1\f51\fs20\ql principal amount of the outstanding debt securities of that series other conflicting directions within 90 days after\plain\intbl\cf1\f51\fs20\ql the notice, request and offer.\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh742\row}}}\pard\plain\sb264\fi462\cf1\f51\fs20\ql These limitations do not apply to a suit instituted by a holder of debt securities if we default in the payment of the\plain\cf1\f51\fs20\ql principal, premium, if any, or interest on, the debt securities, or other defaults that may be specified in the applicable prospectus\plain\cf1\f51\fs20\ql supplement.\par\pard\plain\sb264\fi462\cf1\f51\fs20\ql We will periodically file statements with the trustee regarding our compliance with specified covenants in the indentures.\par\pard\plain\sb264\fi462\cf1\f51\fs20\ql The indentures provide that if a default occurs and is continuing and is actually known to a responsible officer of the\plain\cf1\f51\fs20\ql trustee, the trustee must mail to each holder notice of the default within the earlier of 90 days after it occurs and 30 days after it\plain\cf1\f51\fs20\ql is known by a responsible officer of the trustee or written notice of it is received by the trustee, unless such default has been\plain\cf1\f51\fs20\ql cured or waived. Except in the case of a default in the payment of principal or premium of, or interest on, any debt security or\plain\cf1\f51\fs20\ql certain other defaults specified in an indenture, the trustee shall be protected in withholding such notice if and so long as the\plain\cf1\f51\fs20\ql board of directors, the executive committee or a trust committee of directors, or responsible officers of the trustee, in good faith\plain\cf1\f51\fs20\ql determine that withholding notice is in the best interests of holders of the relevant series of debt securities.\par\pard\plain\cf1\f51\fs16\ql \~\par\pard\plain\cf1\f51\fs20\qc 14
\page\par\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par\par\pard\plain\ul{\field{\*\fldinst HYPERLINK \\l "toc_11558912" }{\*\fldrslt\cf3\f52\fs16\b\ql Table of Contents}}\par\pard\plain\li88\cf1\f51\fs20\b\i\ql Modification of Indenture; Waiver\par\pard\plain\sb132\fi462\cf1\f51\fs20\ql Subject to the terms of the indenture for any series of debt securities that we may issue, we and the trustee may change an\plain\cf1\f51\fs20\ql indenture without the consent of any holders with respect to the following specific matters:\par\pard\plain\cf1\f51\fs12\ql \~
\par\pard\plain
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql to fix any ambiguity, defect or inconsistency in the indenture;\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248\row}}}\pard\plain\cf1\f51\fs12\ql \~
\par\pard\plain
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh495
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql to comply with the provisions described above under \u8220?Description of Debt Securities \u8212?\plain\intbl\cf1\f51\fs20\ql Consolidation, Merger or Sale;\u8221?\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh495\row}}}\pard\plain\cf1\f51\fs12\ql \~
\par\pard\plain
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh495
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql to comply with any requirements of the SEC in connection with the qualification of any indenture under the Trust\plain\intbl\cf1\f51\fs20\ql Indenture Act;\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh495\row}}}\pard\plain\cf1\f51\fs12\ql \~
\par\pard\plain
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh495
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql to add to, delete from or revise the conditions, limitations and restrictions on the authorized amount, terms or\plain\intbl\cf1\f51\fs20\ql purposes of issue, authentication and delivery of debt securities, as set forth in the indenture;\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh495\row}}}\pard\plain\cf1\f51\fs12\ql \~
\par\pard\plain
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh990
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql to provide for the issuance of, and establish the form and terms and conditions of, the debt securities of any\plain\intbl\cf1\f51\fs20\ql series as provided under \u8220?Description of Debt Securities \u8212? General,\u8221? to establish the form of\plain\intbl\cf1\f51\fs20\ql any certifications required to be furnished pursuant to the terms of the indenture or any series of debt securities,\plain\intbl\cf1\f51\fs20\ql or to add to the rights of the holders of any series of debt securities;\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh990\row}}}\pard\plain\cf1\f51\fs12\ql \~
\par\pard\plain
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql to evidence and provide for the acceptance of appointment hereunder by a successor trustee;\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248\row}}}\pard\plain\cf1\f51\fs12\ql \~
\par\pard\plain
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql to provide for uncertificated debt securities and to make all appropriate changes for such purpose;\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248\row}}}\pard\plain\cf1\f51\fs12\ql \~
\par\pard\plain
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh742
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql to add such new covenants, restrictions, conditions or provisions for the benefit of the holders, to make the\plain\intbl\cf1\f51\fs20\ql occurrence, or the occurrence and the continuance, of a default in any such additional covenants, restrictions,\plain\intbl\cf1\f51\fs20\ql conditions or provisions an event of default or to surrender any right or power conferred to us in the indenture; or\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh742\row}}}\pard\plain\cf1\f51\fs12\ql \~
\par\pard\plain
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh495
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql to change anything that does not adversely affect the interests of any holder of debt securities of any series in any\plain\intbl\cf1\f51\fs20\ql material respect.\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh495\row}}}\pard\plain\sb264\fi462\cf1\f51\fs20\ql In addition, under the indentures, the rights of holders of a series of debt securities may be changed by us and the trustee\plain\cf1\f51\fs20\ql with the written consent of the holders of at least a majority in aggregate principal amount of the outstanding debt securities of\plain\cf1\f51\fs20\ql each series that is affected. However, subject to the terms of the indenture for any series of debt securities that we may issue or\plain\cf1\f51\fs20\ql otherwise provided in the prospectus supplement applicable to a particular series of debt securities, we and the trustee may only\plain\cf1\f51\fs20\ql make the following changes with the consent of each holder of any outstanding debt securities affected:\par\pard\plain\cf1\f51\fs12\ql \~
\par\pard\plain
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql extending the stated maturity of the series of debt securities;\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248\row}}}\pard\plain\cf1\f51\fs12\ql \~
\par\pard\plain
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh495
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql reducing the principal amount, reducing the rate of or extending the time of payment of interest, or reducing any\plain\intbl\cf1\f51\fs20\ql premium payable upon the redemption or repurchase of any debt securities; or\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh495\row}}}\pard\plain\cf1\f51\fs12\ql \~
\par\pard\plain
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh495
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql reducing the percentage of debt securities, the holders of which are required to consent to any amendment,\plain\intbl\cf1\f51\fs20\ql supplement, modification or waiver.\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh495\row}}}\pard\plain\li88\sb396\cf1\f51\fs20\b\i\ql Discharge\par\pard\plain\sb132\fi462\cf1\f51\fs20\ql Each indenture provides that, subject to the terms of the indenture and any limitation otherwise provided in the prospectus\plain\cf1\f51\fs20\ql supplement applicable to a particular series of debt securities, we may elect to be discharged from our obligations with respect to\plain\cf1\f51\fs20\ql one or more series of debt securities, except for specified obligations, including obligations to:\par\pard\plain\cf1\f51\fs12\ql \~
\par\pard\plain
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql register the transfer or exchange of debt securities of the series;\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248\row}}}\pard\plain\cf1\f51\fs12\ql \~
\par\pard\plain
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql replace stolen, lost or mutilated debt securities of the series;\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248\row}}}\pard\plain\cf1\f51\fs12\ql \~
\par\pard\plain
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql maintain paying agencies;\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248\row}}}\pard\plain\cf1\f51\fs16\ql \~\par\pard\plain\cf1\f51\fs20\qc 15
\page\par\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par\par\pard\plain\ul{\field{\*\fldinst HYPERLINK \\l "toc_11558912" }{\*\fldrslt\cf3\f52\fs16\b\ql Table of Contents}}
\par\pard\plain
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql hold monies for payment in trust;\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248\row}}}\pard\plain\cf1\f51\fs12\ql \~
\par\pard\plain
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql recover excess money held by the trustee;\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248\row}}}\pard\plain\cf1\f51\fs12\ql \~
\par\pard\plain
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql compensate and indemnify the trustee; and\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248\row}}}\pard\plain\cf1\f51\fs12\ql \~
\par\pard\plain
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql appoint any successor trustee.\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248\row}}}\pard\plain\sb264\fi462\cf1\f51\fs20\ql In order to exercise our rights to be discharged, we must deposit with the trustee money or government obligations\plain\cf1\f51\fs20\ql sufficient to pay all the principal of, and any premium and interest on, the debt securities of the series on the dates payments are\plain\cf1\f51\fs20\ql due.\par\pard\plain\li88\sb396\cf1\f51\fs20\b\i\ql Form, Exchange and Transfer\par\pard\plain\sb132\fi462\cf1\f51\fs20\ql We will issue the debt securities of each series only in fully registered form without coupons and, unless we otherwise\plain\cf1\f51\fs20\ql specify in the applicable prospectus supplement, in denominations of $1,000 and any integral multiple thereof. The indentures\plain\cf1\f51\fs20\ql provide that we may issue debt securities of a series in temporary or permanent global form and as book-entry securities that\plain\cf1\f51\fs20\ql will be deposited with, or on behalf of, The Depository Trust Company or another depositary named by us and identified in a\plain\cf1\f51\fs20\ql prospectus supplement with respect to that series. See \u8220?Legal Ownership of Securities\u8221? below for a further\plain\cf1\f51\fs20\ql description of the terms relating to any book-entry securities.\par\pard\plain\sb264\fi462\cf1\f51\fs20\ql At the option of the holder, subject to the terms of the indentures and the limitations applicable to global securities\plain\cf1\f51\fs20\ql described in the applicable prospectus supplement, the holder of the debt securities of any series can exchange the debt securities\plain\cf1\f51\fs20\ql for other debt securities of the same series, in any authorized denomination and of like tenor and aggregate principal amount.\par\pard\plain\sb264\fi462\cf1\f51\fs20\ql Subject to the terms of the indentures and the limitations applicable to global securities set forth in the applicable prospectus\plain\cf1\f51\fs20\ql supplement, holders of the debt securities may present the debt securities for exchange or for registration of transfer, duly\plain\cf1\f51\fs20\ql endorsed or with the form of transfer endorsed thereon duly executed if so required by us or the security registrar, at the office of\plain\cf1\f51\fs20\ql the security registrar or at the office of any transfer agent designated by us for this purpose. Unless otherwise provided in the\plain\cf1\f51\fs20\ql debt securities that the holder presents for transfer or exchange, we will make no service charge for any registration of transfer or\plain\cf1\f51\fs20\ql exchange, but we may require payment of any taxes or other governmental charges.\par\pard\plain\sb264\fi462\cf1\f51\fs20\ql We will name in the applicable prospectus supplement the security registrar, and any transfer agent in addition to the\plain\cf1\f51\fs20\ql security registrar, that we initially designate for any debt securities. We may at any time designate additional transfer agents or\plain\cf1\f51\fs20\ql rescind the designation of any transfer agent or approve a change in the office through which any transfer agent acts, except that\plain\cf1\f51\fs20\ql we will be required to maintain a transfer agent in each place of payment for the debt securities of each series.\par\pard\plain\sb264\fi462\cf1\f51\fs20\ql If we elect to redeem the debt securities of any series, we will not be required to:\par\pard\plain\cf1\f51\fs12\ql \~
\par\pard\plain
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh742
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql issue, register the transfer of, or exchange any debt securities of that series during a period beginning at the\plain\intbl\cf1\f51\fs20\ql opening of business 15 days before the day of mailing of a notice of redemption of any debt securities that may\plain\intbl\cf1\f51\fs20\ql be selected for redemption and ending at the close of business on the day of the mailing; or\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh742\row}}}\pard\plain\cf1\f51\fs12\ql \~
\par\pard\plain
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh495
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql register the transfer of or exchange any debt securities so selected for redemption, in whole or in part, except the\plain\intbl\cf1\f51\fs20\ql unredeemed portion of any debt securities we are redeeming in part.\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh495\row}}}\pard\plain\li88\sb396\cf1\f51\fs20\b\i\ql Information Concerning the Trustee\par\pard\plain\sb132\fi462\cf1\f51\fs20\ql The trustee, other than during the occurrence and continuance of an event of default under an indenture, undertakes to\plain\cf1\f51\fs20\ql perform only those duties as are specifically set forth in the applicable indenture and is under no\par\pard\plain\cf1\f51\fs16\ql \~\par\pard\plain\cf1\f51\fs20\qc 16
\page\par\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par\par\pard\plain\ul{\field{\*\fldinst HYPERLINK \\l "toc_11558912" }{\*\fldrslt\cf3\f52\fs16\b\ql Table of Contents}}\par\pard\plain\cf1\f51\fs20\ql obligation to exercise any of the powers given it by the indentures at the request of any holder of debt securities unless it is\plain\cf1\f51\fs20\ql offered reasonable security and indemnity against the costs, expenses and liabilities that it might incur. However, upon an event\plain\cf1\f51\fs20\ql of default under an indenture, the trustee must use the same degree of care as a prudent person would exercise or use in the\plain\cf1\f51\fs20\ql conduct of his or her own affairs.\par\pard\plain\li88\sb396\cf1\f51\fs20\b\i\ql Payment and Paying Agents\par\pard\plain\sb132\fi462\cf1\f51\fs20\ql Unless we otherwise indicate in the applicable prospectus supplement, we will make payment of the interest on any debt\plain\cf1\f51\fs20\ql securities on any interest payment date to the person in whose name the debt securities, or one or more predecessor securities, are\plain\cf1\f51\fs20\ql registered at the close of business on the regular record date for the interest payment.\par\pard\plain\sb264\fi462\cf1\f51\fs20\ql We will pay principal of and any premium and interest on the debt securities of a particular series at the office of the\plain\cf1\f51\fs20\ql paying agents designated by us, except that unless we otherwise indicate in the applicable prospectus supplement, we will make\plain\cf1\f51\fs20\ql interest payments by check that we will mail to the holder or by wire transfer to certain holders. Unless we otherwise indicate in\plain\cf1\f51\fs20\ql the applicable prospectus supplement, we will designate the corporate trust office of the trustee as our sole paying agent for\plain\cf1\f51\fs20\ql payments with respect to debt securities of each series. We will name in the applicable prospectus supplement any other paying\plain\cf1\f51\fs20\ql agents that we initially designate for the debt securities of a particular series. We will maintain a paying agent in each place of\plain\cf1\f51\fs20\ql payment for the debt securities of a particular series.\par\pard\plain\sb264\fi462\cf1\f51\fs20\ql All money we pay to a paying agent or the trustee for the payment of the principal of or any premium or interest on any\plain\cf1\f51\fs20\ql debt securities that remains unclaimed at the end of two years after such principal, premium or interest has become due and\plain\cf1\f51\fs20\ql payable will be repaid to us, and the holder of the debt security thereafter may look only to us for payment thereof.\par\pard\plain\li88\sb396\cf1\f51\fs20\b\i\ql Governing Law\par\pard\plain\sb132\fi462\cf1\f51\fs20\ql The indentures and the debt securities will be governed by and construed in accordance with the laws of the State of New\plain\cf1\f51\fs20\ql York, except to the extent that the Trust Indenture Act is applicable.\par\pard\plain\li44\sb396\cf1\f51\fs20\b\i\ql Ranking Debt Securities\par\pard\plain\sb132\fi462\cf1\f51\fs20\ql The subordinated debt securities will be unsecured and will be subordinate and junior in priority of payment to certain other\plain\cf1\f51\fs20\ql indebtedness to the extent described in a prospectus supplement. The subordinated indenture does not limit the amount of\plain\cf1\f51\fs20\ql subordinated debt securities that we may issue. It also does not limit us from issuing any other secured or unsecured debt.\par\pard\plain\sb264\fi462\cf1\f51\fs20\ql The senior debt securities will be unsecured and will rank equally in right of payment to all our other senior unsecured debt.\plain\cf1\f51\fs20\ql The senior indenture does not limit the amount of senior debt securities that we may issue. It also does not limit us from issuing\plain\cf1\f51\fs20\ql any other secured or unsecured debt.\par\pard\plain\li88\sb396\cf1\f51\fs20\b\i\ql Existing Subordinated Debt\par\pard\plain\sb132\fi462\cf1\f51\fs20\ql As of December\~31, 2014, we had no existing subordinated debt.\par\pard\plain\cf1\f51\fs16\ql \~\par\pard\plain\cf1\f51\fs20\qc 17
\page\par\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par\par\pard\plain\ul{\field{\*\fldinst HYPERLINK \\l "toc_11558912" }{\*\fldrslt\cf3\f52\fs16\b\ql Table of Contents}}{\*\bkmkstart toc357361_9_11558912}{\*\bkmkend toc357361_9_11558912}\par\pard\plain\cf1\f51\fs20\b\qc DESCRIPTION OF WARRANTS\par\pard\plain\li88\sb264\cf1\f51\fs20\b\i\ql General\par\pard\plain\sb132\fi462\cf1\f51\fs20\ql We may issue warrants for the purchase of common stock, preferred stock or debt securities. Warrants may be offered\plain\cf1\f51\fs20\ql independently or together with common stock, preferred stock or debt securities offered by any prospectus supplement and may\plain\cf1\f51\fs20\ql be attached to or separate from those securities. While the terms we have summarized below will apply generally to any warrants\plain\cf1\f51\fs20\ql that we may offer under this prospectus, we will describe in particular the terms of any series of warrants that we may offer in\plain\cf1\f51\fs20\ql more detail in the applicable prospectus supplement and any applicable free writing prospectus. The terms of any warrants\plain\cf1\f51\fs20\ql offered under a prospectus supplement may differ from the terms described below.\par\pard\plain\sb264\fi462\cf1\f51\fs20\ql We will file as an exhibit to the registration statement of which this prospectus is a part, or will incorporate by reference\plain\cf1\f51\fs20\ql from another report that we file with the SEC, the form of warrant and/or warrant agreement, which may include a form of\plain\cf1\f51\fs20\ql warrant certificate, as applicable, that describes the terms of the particular series of warrants we may offer before the issuance of\plain\cf1\f51\fs20\ql the related series of warrants. We may issue the warrants under a warrant agreement that we will enter into with a warrant agent\plain\cf1\f51\fs20\ql to be selected by us. The warrant agent will act solely as our agent in connection with the warrants and will not assume any\plain\cf1\f51\fs20\ql obligation or relationship of agency or trust for or with any registered holders of warrants or beneficial owners of warrants. The\plain\cf1\f51\fs20\ql following summary of material provisions of the warrants and warrant agreements are subject to, and qualified in their entirety by\plain\cf1\f51\fs20\ql reference to, all the provisions of the form of warrant and/or warrant agreement and warrant certificate applicable to a particular\plain\cf1\f51\fs20\ql series of warrants. We urge you to read the applicable prospectus supplement and any related free writing prospectus, as well as\plain\cf1\f51\fs20\ql the complete form of warrant and/or the warrant agreement and warrant certificate, as applicable, that contain the terms of the\plain\cf1\f51\fs20\ql warrants.\par\pard\plain\sb264\fi462\cf1\f51\fs20\ql The particular terms of any issue of warrants will be described in the prospectus supplement relating to the issue. Those\plain\cf1\f51\fs20\ql terms may include:\par\pard\plain\cf1\f51\fs12\ql \~
\par\pard\plain
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql the title of such warrants;\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248\row}}}\pard\plain\cf1\f51\fs12\ql \~
\par\pard\plain
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql the aggregate number of such warrants;\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248\row}}}\pard\plain\cf1\f51\fs12\ql \~
\par\pard\plain
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql the price or prices at which such warrants will be issued;\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248\row}}}\pard\plain\cf1\f51\fs12\ql \~
\par\pard\plain
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql the currency or currencies (including composite currencies) in which the price of such warrants may be payable;\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248\row}}}\pard\plain\cf1\f51\fs12\ql \~
\par\pard\plain
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh495
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql the terms of the securities purchasable upon exercise of such warrants and the procedures and conditions relating\plain\intbl\cf1\f51\fs20\ql to the exercise of such warrants;\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh495\row}}}\pard\plain\cf1\f51\fs12\ql \~
\par\pard\plain
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql the price at which the securities purchasable upon exercise of such warrants may be purchased;\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248\row}}}\pard\plain\cf1\f51\fs12\ql \~
\par\pard\plain
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh495
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql the date on which the right to exercise such warrants will commence and the date on which such right shall\plain\intbl\cf1\f51\fs20\ql expire;\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh495\row}}}\pard\plain\cf1\f51\fs12\ql \~
\par\pard\plain
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh495
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql any provisions for adjustment of the number or amount of securities receivable upon exercise of the warrants or\plain\intbl\cf1\f51\fs20\ql the exercise price of the warrants;\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh495\row}}}\pard\plain\cf1\f51\fs12\ql \~
\par\pard\plain
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql if applicable, the minimum or maximum amount of such warrants that may be exercised at any one time;\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248\row}}}\pard\plain\cf1\f51\fs12\ql \~
\par\pard\plain
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh495
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql if applicable, the designation and terms of the securities with which such warrants are issued and the number of\plain\intbl\cf1\f51\fs20\ql such warrants issued with each such security;\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh495\row}}}\pard\plain\cf1\f51\fs12\ql \~
\par\pard\plain
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql if applicable, the date on and after which such warrants and the related securities will be separately transferable;\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248\row}}}\pard\plain\cf1\f51\fs16\ql \~\par\pard\plain\cf1\f51\fs20\qc 18
\page\par\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par\par\pard\plain\ul{\field{\*\fldinst HYPERLINK \\l "toc_11558912" }{\*\fldrslt\cf3\f52\fs16\b\ql Table of Contents}}
\par\pard\plain
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql information with respect to book-entry procedures, if any;\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248\row}}}\pard\plain\cf1\f51\fs12\ql \~
\par\pard\plain
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql the terms of any rights to redeem or call the warrants;\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248\row}}}\pard\plain\cf1\f51\fs12\ql \~
\par\pard\plain
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql United States federal income tax consequences of holding or exercising the warrants, if material; and\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248\row}}}\pard\plain\cf1\f51\fs12\ql \~
\par\pard\plain
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh495
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql any other terms of such warrants, including terms, procedures and limitations relating to the exchange or exercise\plain\intbl\cf1\f51\fs20\ql of such warrants.\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh495\row}}}\pard\plain\sb264\fi462\cf1\f51\fs20\ql Each warrant will entitle its holder to purchase the principal amount of debt securities or the number of shares of preferred\plain\cf1\f51\fs20\ql stock or common stock at the exercise price set forth in, or calculable as set forth in, the applicable prospectus supplement. The\plain\cf1\f51\fs20\ql warrants may be exercised as set forth in the prospectus supplement relating to the warrants offered. Unless we otherwise specify\plain\cf1\f51\fs20\ql in the applicable prospectus supplement, warrants may be exercised at any time up to the close of business on the expiration date\plain\cf1\f51\fs20\ql set forth in the prospectus supplement relating to the warrants offered thereby. After the close of business on the expiration date,\plain\cf1\f51\fs20\ql unexercised warrants will become void.\par\pard\plain\sb264\fi462\cf1\f51\fs20\ql We will specify the place or places where, and the manner in which, warrants may be exercised in the form of warrant,\plain\cf1\f51\fs20\ql warrant agreement or warrant certificate and applicable prospectus supplement. Upon receipt of payment and the warrant or\plain\cf1\f51\fs20\ql warrant certificate, as applicable, properly completed and duly executed at the corporate trust office of the warrant agent, if any,\plain\cf1\f51\fs20\ql or any other office, including ours, indicated in the prospectus supplement, we will, as soon as practicable, issue and deliver the\plain\cf1\f51\fs20\ql securities purchasable upon such exercise. If less than all of the warrants (or the warrants represented by such warrant certificate)\plain\cf1\f51\fs20\ql are exercised, a new warrant or a new warrant certificate, as applicable, will be issued for the remaining amount of warrants. If\plain\cf1\f51\fs20\ql we so indicate in the applicable prospectus supplement, holders of the warrants may surrender securities as all or part of the\plain\cf1\f51\fs20\ql exercise price for warrants.\par\pard\plain\sb264\fi462\cf1\f51\fs20\ql Prior to the exercise of any warrants to purchase common stock, preferred stock or debt securities, holders of the warrants\plain\cf1\f51\fs20\ql will not have any of the rights of holders of the common stock, preferred stock or debt securities purchasable upon exercise,\plain\cf1\f51\fs20\ql including (i)\~in the case of warrants for the purchase of common stock or preferred stock, the right to vote or to receive any\plain\cf1\f51\fs20\ql payments of dividends or payments upon our liquidation, dissolution or winding up on the common stock or preferred stock\plain\cf1\f51\fs20\ql purchasable upon exercise, if any; or (ii)\~in the case of warrants for the purchase of debt securities, the right to receive payments\plain\cf1\f51\fs20\ql of principal of, any premium or interest on the debt securities purchasable upon exercise or to enforce covenants in the applicable\plain\cf1\f51\fs20\ql indenture.\par\pard\plain\li88\sb396\cf1\f51\fs20\b\i\ql Outstanding Warrants\par\pard\plain\sb132\fi462\cf1\f51\fs20\ql As of March\~20, 2015, there were outstanding warrants to purchase 79,149,568 shares of our common stock, of which\plain\cf1\f51\fs20\ql warrants to purchase 409,228 shares were outstanding with an exercise price of $3.44 per share, warrants to purchase 1,062,500\plain\cf1\f51\fs20\ql shares were outstanding with an exercise price of $1.00 per share, warrants to purchase 1,816,608 shares were outstanding with\plain\cf1\f51\fs20\ql an exercise price of $3.65 per share, warrants to purchase 2,046,139 shares were outstanding with an exercise price of $2.75 per\plain\cf1\f51\fs20\ql share, warrants to purchase 10,625,000 shares were outstanding with an exercise price of $1.10 per share, warrants to purchase\plain\cf1\f51\fs20\ql 28,097,400 shares were outstanding with an exercise price of $0.65 per share, warrants to purchase 13,081,428 shares were\plain\cf1\f51\fs20\ql outstanding with an exercise price of $0.01 per share, and warrants to purchase 22,011,265 shares were outstanding with an\plain\cf1\f51\fs20\ql exercise price of $0.75 per share. The warrants may be exercised for cash or, under certain circumstances, on a cashless basis, in\plain\cf1\f51\fs20\ql which case we will deliver, upon exercise, the number of shares with respect to which the warrant is being exercised reduced by\plain\cf1\f51\fs20\ql a number of shares having a value (as determined in accordance with the terms of the applicable warrant) equal to the aggregate\plain\cf1\f51\fs20\ql exercise price of the shares with respect to which the warrant is being exercised.\par\pard\plain\cf1\f51\fs16\ql \~\par\pard\plain\cf1\f51\fs20\qc 19
\page\par\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par\par\pard\plain\ul{\field{\*\fldinst HYPERLINK \\l "toc_11558912" }{\*\fldrslt\cf3\f52\fs16\b\ql Table of Contents}}{\*\bkmkstart toc357361_10_11558912}{\*\bkmkend toc357361_10_11558912}\par\pard\plain\cf1\f51\fs20\b\qc DESCRIPTION OF UNITS\par\pard\plain\sb264\fi462\cf1\f51\fs20\ql The following description, together with the additional information we may include in any applicable prospectus supplement,\plain\cf1\f51\fs20\ql summarizes the material terms and provisions of the units that we may offer under this prospectus. While the terms we have\plain\cf1\f51\fs20\ql summarized below will apply generally to any units that we may offer under this prospectus, we will describe the particular\plain\cf1\f51\fs20\ql terms of any series of units in more detail in the applicable prospectus supplement and any related free writing prospectus. The\plain\cf1\f51\fs20\ql terms of any units offered under a prospectus supplement may differ from the terms described below. However, no prospectus\plain\cf1\f51\fs20\ql supplement will fundamentally change the terms that are set forth in this prospectus or offer a security that is not registered and\plain\cf1\f51\fs20\ql described in this prospectus at the time of its effectiveness.\par\pard\plain\sb264\fi462\cf1\f51\fs20\ql We will file as an exhibit to the registration statement of which this prospectus is a part, or will incorporate by reference\plain\cf1\f51\fs20\ql from another report we file with the SEC, the form of unit agreement that describes the terms of the series of units we may offer\plain\cf1\f51\fs20\ql under this prospectus, and any supplemental agreements, before the issuance of the related series of units. The following\plain\cf1\f51\fs20\ql summaries of material terms and provisions of the units are subject to, and qualified in their entirety by reference to, all the\plain\cf1\f51\fs20\ql provisions of the unit agreement and any supplemental agreements applicable to a particular series of units. We urge you to read\plain\cf1\f51\fs20\ql the applicable prospectus supplement and any related free writing prospectus, as well as the complete unit agreement and any\plain\cf1\f51\fs20\ql supplemental agreements that contain the terms of the units.\par\pard\plain\li88\sb396\cf1\f51\fs20\b\i\ql General\par\pard\plain\sb132\fi462\cf1\f51\fs20\ql We may issue units comprised of one or more debt securities, shares of common stock, shares of preferred stock and\plain\cf1\f51\fs20\ql warrants in any combination. Each unit will be issued so that the holder of the unit is also the holder of each security included in\plain\cf1\f51\fs20\ql the unit. Thus, the holder of a unit will have the rights and obligations of a holder of each included security. The unit agreement\plain\cf1\f51\fs20\ql under which a unit is issued may provide that the securities included in the unit may not be held or transferred separately, at any\plain\cf1\f51\fs20\ql time or at any time before a specified date.\par\pard\plain\sb264\fi462\cf1\f51\fs20\ql We will describe in the applicable prospectus supplement the terms of the series of units, including, but not limited to:\par\pard\plain\cf1\f51\fs12\ql \~
\par\pard\plain
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh495
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql the designation and terms of the units and of the securities comprising the units, including whether and under\plain\intbl\cf1\f51\fs20\ql what circumstances those securities may be held or transferred separately;\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh495\row}}}\pard\plain\cf1\f51\fs12\ql \~
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\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql any provisions of the governing unit agreement that differ from those described below; and\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248\row}}}\pard\plain\cf1\f51\fs12\ql \~
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{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh495
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql any provisions for the issuance, payment, settlement, transfer or exchange of the units or of the securities\plain\intbl\cf1\f51\fs20\ql comprising the units.\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh495\row}}}\pard\plain\sb264\fi462\cf1\f51\fs20\ql The provisions described in this section, as well as those described under \u8220?Description of Common Stock and\plain\cf1\f51\fs20\ql Preferred Stock,\u8221? \u8220?Description of Debt Securities\u8221? and \u8220?Description of Warrants\u8221? will apply to\plain\cf1\f51\fs20\ql each unit and to any common stock, preferred stock, debt security or warrant included in each unit, respectively.\par\pard\plain\li88\sb396\cf1\f51\fs20\b\i\ql Issuance in Series\par\pard\plain\sb132\fi462\cf1\f51\fs20\ql We may issue units in such amounts and in numerous distinct series as we determine.\par\pard\plain\li88\sb396\cf1\f51\fs20\b\i\ql Enforceability of Rights by Holders of Units\par\pard\plain\sb132\fi462\cf1\f51\fs20\ql Each unit agent will act solely as our agent under the applicable unit agreement and will not assume any obligation or\plain\cf1\f51\fs20\ql relationship of agency or trust with any holder of any unit. A single bank or trust company may act as unit agent for more than\plain\cf1\f51\fs20\ql one series of units. A unit agent will have no duty or responsibility in case of any default by us under the applicable unit\plain\cf1\f51\fs20\ql agreement or unit, including any duty or responsibility to initiate any\par\pard\plain\cf1\f51\fs16\ql \~\par\pard\plain\cf1\f51\fs20\qc 20
\page\par\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par\par\pard\plain\ul{\field{\*\fldinst HYPERLINK \\l "toc_11558912" }{\*\fldrslt\cf3\f52\fs16\b\ql Table of Contents}}\par\pard\plain\cf1\f51\fs20\ql proceedings at law or otherwise, or to make any demand upon us. Any holder of a unit may, without the consent of the related\plain\cf1\f51\fs20\ql unit agent or the holder of any other unit, enforce by appropriate legal action its rights as holder under any security included in\plain\cf1\f51\fs20\ql the unit.\par\pard\plain\sb264\fi462\cf1\f51\fs20\ql We, the unit agents and any of their agents may treat the registered holder of any unit certificate as an absolute owner of\plain\cf1\f51\fs20\ql the units evidenced by that certificate for any purpose and as the person entitled to exercise the rights attaching to the units so\plain\cf1\f51\fs20\ql requested, despite any notice to the contrary.{\*\bkmkstart toc357361_11_11558912}{\*\bkmkend toc357361_11_11558912}\par\pard\plain\sb528\cf1\f51\fs20\b\qc LEGAL OWNERSHIP OF SECURITIES\par\pard\plain\sb264\fi462\cf1\f51\fs20\ql We can issue securities in registered form or in the form of one or more global securities. We describe global securities in\plain\cf1\f51\fs20\ql greater detail below. We refer to those persons who have securities registered in their own names on the books that we or any\plain\cf1\f51\fs20\ql applicable trustee or depositary or warrant agent maintain for this purpose as the \u8220?holders\u8221? of those securities. These\plain\cf1\f51\fs20\ql persons are the legal holders of the securities. We refer to those persons who, indirectly through others, own beneficial interests\plain\cf1\f51\fs20\ql in securities that are not registered in their own names, as \u8220?indirect holders\u8221? of those securities. As we discuss\plain\cf1\f51\fs20\ql below, indirect holders are not legal holders, and investors in securities issued in book-entry form or in \u8220?street\plain\cf1\f51\fs20\ql name\u8221? will be indirect holders.\par\pard\plain\li88\sb396\cf1\f51\fs20\b\i\ql Book-Entry Holders\par\pard\plain\sb132\fi462\cf1\f51\fs20\ql We may issue securities in book-entry form only, as we will specify in the applicable prospectus supplement. This means\plain\cf1\f51\fs20\ql securities may be represented by one or more global securities registered in the name of a financial institution that holds them as\plain\cf1\f51\fs20\ql depositary on behalf of other financial institutions that participate in the depositary\u8217?s book-entry system. These\plain\cf1\f51\fs20\ql participating institutions, which are referred to as participants, in turn, hold beneficial interests in the securities on behalf of\plain\cf1\f51\fs20\ql themselves or their customers.\par\pard\plain\sb264\fi462\cf1\f51\fs20\ql Only the person in whose name a security is registered is recognized as the holder of that security. Global securities will be\plain\cf1\f51\fs20\ql registered in the name of the depositary. Consequently, for global securities, we will recognize only the depositary as the holder\plain\cf1\f51\fs20\ql of the securities, and we will make all payments on the securities to the depositary. The depositary passes along the payments it\plain\cf1\f51\fs20\ql receives to its participants, which in turn pass the payments along to their customers who are the beneficial owners. The\plain\cf1\f51\fs20\ql depositary and its participants do so under agreements they have made with one another or with their customers; they are not\plain\cf1\f51\fs20\ql obligated to do so under the terms of the securities.\par\pard\plain\sb264\fi462\cf1\f51\fs20\ql As a result, investors in a global security will not own securities directly. Instead, they will own beneficial interests in a\plain\cf1\f51\fs20\ql global security, through a bank, broker or other financial institution that participates in the depositary\u8217?s book-entry system\plain\cf1\f51\fs20\ql or holds an interest through a participant. As long as the securities are issued in global form, investors will be indirect holders,\plain\cf1\f51\fs20\ql and not legal holders, of the securities.\par\pard\plain\li88\sb396\cf1\f51\fs20\b\i\ql Street Name Holders\par\pard\plain\sb132\fi462\cf1\f51\fs20\ql We may terminate a global security or issue securities that are not issued in global form. In these cases, investors may\plain\cf1\f51\fs20\ql choose to hold their securities in their own names or in \u8220?street name.\u8221? Securities held by an investor in street name\plain\cf1\f51\fs20\ql would be registered in the name of a bank, broker or other financial institution that the investor chooses, and the investor would\plain\cf1\f51\fs20\ql hold only a beneficial interest in those securities through an account he or she maintains at that institution.\par\pard\plain\sb264\fi462\cf1\f51\fs20\ql For securities held in street name, we or any applicable trustee or depositary will recognize only the intermediary banks,\plain\cf1\f51\fs20\ql brokers and other financial institutions in whose names the securities are registered as the holders of those securities, and we or\plain\cf1\f51\fs20\ql any such trustee or depositary will make all payments on those securities to them. These institutions pass along the payments\plain\cf1\f51\fs20\ql they receive to their customers who are the beneficial owners,\par\pard\plain\cf1\f51\fs16\ql \~\par\pard\plain\cf1\f51\fs20\qc 21
\page\par\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par\par\pard\plain\ul{\field{\*\fldinst HYPERLINK \\l "toc_11558912" }{\*\fldrslt\cf3\f52\fs16\b\ql Table of Contents}}\par\pard\plain\cf1\f51\fs20\ql but only because they agree to do so in their customer agreements or because they are legally required to do so. Investors who\plain\cf1\f51\fs20\ql hold securities in street name will be indirect holders, not legal holders, of those securities.\par\pard\plain\li88\sb396\cf1\f51\fs20\b\i\ql Legal Holders\par\pard\plain\sb132\fi462\cf1\f51\fs20\ql Our obligations, as well as the obligations of any applicable trustee or third party employed by us or a trustee, run only to\plain\cf1\f51\fs20\ql the legal holders of the securities. We do not have obligations to investors who hold beneficial interests in global securities, in\plain\cf1\f51\fs20\ql street name or by any other indirect means. This will be the case whether an investor chooses to be an indirect holder of a\plain\cf1\f51\fs20\ql security or has no choice because we are issuing the securities only in global form.\par\pard\plain\sb264\fi462\cf1\f51\fs20\ql For example, once we make a payment or give a notice to the legal holder, we have no further responsibility for the\plain\cf1\f51\fs20\ql payment or notice even if that holder is required, under agreements with its participants or customers or by law, to pass it along\plain\cf1\f51\fs20\ql to the indirect holders but does not do so. Similarly, we may want to obtain the approval of the legal holders to amend an\plain\cf1\f51\fs20\ql indenture, to relieve us of the consequences of a default or of our obligation to comply with a particular provision of an\plain\cf1\f51\fs20\ql indenture, or for other purposes. In such an event, we would seek approval only from the legal holders, and not the indirect\plain\cf1\f51\fs20\ql holders, of the securities. Whether and how the legal holders contact the indirect holders is up to the legal holders.\par\pard\plain\li88\sb396\cf1\f51\fs20\b\i\ql Special Considerations for Indirect Holders\par\pard\plain\sb132\fi462\cf1\f51\fs20\ql If you hold securities through a bank, broker or other financial institution, either in book-entry form because the securities\plain\cf1\f51\fs20\ql are represented by one or more global securities or in street name, you should check with your own institution to find out:\par\pard\plain\cf1\f51\fs12\ql \~
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\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql how it handles securities payments and notices;\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248\row}}}\pard\plain\cf1\f51\fs12\ql \~
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\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql whether it imposes fees or charges;\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248\row}}}\pard\plain\cf1\f51\fs12\ql \~
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{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql how it would handle a request for the legal holders\u8217? consent, if ever required;\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248\row}}}\pard\plain\cf1\f51\fs12\ql \~
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\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql whether and how you can instruct it to send you securities registered in your own name so you can be a legal\plain\intbl\cf1\f51\fs20\ql holder, if that is permitted in the future;\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh495\row}}}\pard\plain\cf1\f51\fs12\ql \~
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{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh495
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql how it would exercise rights under the securities if there were a default or other event triggering the need for\plain\intbl\cf1\f51\fs20\ql legal holders to act to protect their interests; and\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh495\row}}}\pard\plain\cf1\f51\fs12\ql \~
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{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh495
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql if the securities are in book-entry form, how the depositary\u8217?s rules and procedures will affect these\plain\intbl\cf1\f51\fs20\ql matters.\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh495\row}}}\pard\plain\li88\sb396\cf1\f51\fs20\b\i\ql Global Securities\par\pard\plain\sb132\fi462\cf1\f51\fs20\ql A global security is a security that represents one or any other number of individual securities held by a depositary.\plain\cf1\f51\fs20\ql Generally, all securities represented by the same global securities will have the same terms.\par\pard\plain\sb264\fi462\cf1\f51\fs20\ql Each security issued in book-entry form will be represented by a global security that we issue to, deposit with and register\plain\cf1\f51\fs20\ql in the name of a financial institution or its nominee that we select. The financial institution that we select for this purpose is\plain\cf1\f51\fs20\ql called the depositary. Unless we specify otherwise in the applicable prospectus supplement, The Depository Trust Company, New\plain\cf1\f51\fs20\ql York, New York, known as DTC, will be the depositary for all securities issued in book-entry form.\par\pard\plain\sb264\fi462\cf1\f51\fs20\ql A global security may not be transferred to or registered in the name of anyone other than the depositary, its nominee or a\plain\cf1\f51\fs20\ql successor depositary, unless special termination situations arise. We describe those situations below under \u8220?\u8212?Special\plain\cf1\f51\fs20\ql Situations When A Global Security Will Be Terminated.\u8221? As a result of these arrangements, the depositary, or its nominee,\plain\cf1\f51\fs20\ql will be the sole registered owner and legal holder of all securities represented by a\par\pard\plain\cf1\f51\fs16\ql \~\par\pard\plain\cf1\f51\fs20\qc 22
\page\par\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par\par\pard\plain\ul{\field{\*\fldinst HYPERLINK \\l "toc_11558912" }{\*\fldrslt\cf3\f52\fs16\b\ql Table of Contents}}\par\pard\plain\cf1\f51\fs20\ql global security, and investors will be permitted to own only beneficial interests in a global security. Beneficial interests must be\plain\cf1\f51\fs20\ql held by means of an account with a broker, bank or other financial institution that in turn has an account with the depositary or\plain\cf1\f51\fs20\ql with another institution that does. Thus, an investor whose security is represented by a global security will not be a legal holder\plain\cf1\f51\fs20\ql of the security, but only an indirect holder of a beneficial interest in the global security.\par\pard\plain\sb264\fi462\cf1\f51\fs20\ql If the prospectus supplement for a particular security indicates that the security will be issued as a global security, then the\plain\cf1\f51\fs20\ql security will be represented by a global security at all times unless and until the global security is terminated. If termination\plain\cf1\f51\fs20\ql occurs, we may issue the securities through another book-entry clearing system or decide that the securities may no longer be\plain\cf1\f51\fs20\ql held through any book-entry clearing system.\par\pard\plain\li88\sb396\cf1\f51\fs20\b\i\ql Special Considerations For Global Securities\par\pard\plain\sb132\fi462\cf1\f51\fs20\ql As an indirect holder, an investor\u8217?s rights relating to a global security will be governed by the account rules of the\plain\cf1\f51\fs20\ql investor\u8217?s financial institution and of the depositary, as well as general laws relating to securities transfers. We do not\plain\cf1\f51\fs20\ql recognize an indirect holder as a holder of securities and instead deal only with the depositary that holds the global security.\par\pard\plain\sb264\fi462\cf1\f51\fs20\ql If securities are issued only as global securities, an investor should be aware of the following:\par\pard\plain\cf1\f51\fs12\ql \~
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{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh495
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql an investor cannot cause the securities to be registered in his or her name, and cannot obtain non-global\plain\intbl\cf1\f51\fs20\ql certificates for his or her interest in the securities, except in the special situations we describe below;\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh495\row}}}\pard\plain\cf1\f51\fs12\ql \~
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{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh495
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql an investor will be an indirect holder and must look to his or her own bank or broker for payments on the\plain\intbl\cf1\f51\fs20\ql securities and protection of his or her legal rights relating to the securities, as we describe above;\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh495\row}}}\pard\plain\cf1\f51\fs12\ql \~
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{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh495
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql an investor may not be able to sell interests in the securities to some insurance companies and to other\plain\intbl\cf1\f51\fs20\ql institutions that are required by law to own their securities in non-book-entry form;\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh495\row}}}\pard\plain\cf1\f51\fs12\ql \~
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{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh742
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql an investor may not be able to pledge his or her interest in the global security in circumstances where certificates\plain\intbl\cf1\f51\fs20\ql representing the securities must be delivered to the lender or other beneficiary of the pledge in order for the\plain\intbl\cf1\f51\fs20\ql pledge to be effective;\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh742\row}}}\pard\plain\cf1\f51\fs12\ql \~
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{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh990
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql the depositary\u8217?s policies, which may change from time to time, will govern payments, transfers, exchanges\plain\intbl\cf1\f51\fs20\ql and other matters relating to an investor\u8217?s interest in the global security. We and any applicable trustee\plain\intbl\cf1\f51\fs20\ql have no responsibility for any aspect of the depositary\u8217?s actions or for its records of ownership interests in\plain\intbl\cf1\f51\fs20\ql the global security. We and the trustee also do not supervise the depositary in any way;\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh990\row}}}\pard\plain\cf1\f51\fs12\ql \~
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{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh742
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql the depositary may, and we understand that DTC will, require that those who purchase and sell interests in the\plain\intbl\cf1\f51\fs20\ql global security within its book-entry system use immediately available funds, and your broker or bank may\plain\intbl\cf1\f51\fs20\ql require you to do so as well; and\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh742\row}}}\pard\plain\cf1\f51\fs12\ql \~
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{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh990
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql financial institutions that participate in the depositary\u8217?s book-entry system, and through which an investor\plain\intbl\cf1\f51\fs20\ql holds its interest in the global security, may also have their own policies affecting payments, notices and other\plain\intbl\cf1\f51\fs20\ql matters relating to the securities. There may be more than one financial intermediary in the chain of ownership\plain\intbl\cf1\f51\fs20\ql for an investor. We do not monitor and are not responsible for the actions of any of those intermediaries.\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh990\row}}}\pard\plain\li88\sb396\cf1\f51\fs20\b\i\ql Special Situations When a Global Security Will Be Terminated\par\pard\plain\sb132\fi462\cf1\f51\fs20\ql In a few special situations described below, a global security will terminate and interests in it will be exchanged for\plain\cf1\f51\fs20\ql physical certificates representing those interests. After that exchange, the choice of whether to hold securities directly or in street\plain\cf1\f51\fs20\ql name will be up to the investor. Investors must consult their own banks or brokers to find out how to have their interests in\plain\cf1\f51\fs20\ql securities transferred to their own names, so that they will be direct holders. We have described the rights of holders and street\plain\cf1\f51\fs20\ql name investors above.\par\pard\plain\cf1\f51\fs16\ql \~\par\pard\plain\cf1\f51\fs20\qc 23
\page\par\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par\par\pard\plain\ul{\field{\*\fldinst HYPERLINK \\l "toc_11558912" }{\*\fldrslt\cf3\f52\fs16\b\ql Table of Contents}}\par\pard\plain\fi462\cf1\f51\fs20\ql A global security will terminate when the following special situations occur:\par\pard\plain\cf1\f51\fs12\ql \~
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{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh495
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql if the depositary notifies us that it is unwilling, unable or no longer qualified to continue as depositary for that\plain\intbl\cf1\f51\fs20\ql global security and we do not appoint another institution to act as depositary within 90 days;\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh495\row}}}\pard\plain\cf1\f51\fs12\ql \~
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{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql if we notify any applicable trustee that we wish to terminate that global security; or\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248\row}}}\pard\plain\cf1\f51\fs12\ql \~
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{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh495
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql if an event of default has occurred with regard to securities represented by that global security and has not been\plain\intbl\cf1\f51\fs20\ql cured or waived.\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh495\row}}}\pard\plain\sb264\fi462\cf1\f51\fs20\ql The applicable prospectus supplement may also list additional situations for terminating a global security that would apply\plain\cf1\f51\fs20\ql only to the particular series of securities covered by the prospectus supplement. When a global security terminates, the depositary,\plain\cf1\f51\fs20\ql and neither we nor any applicable trustee, is responsible for deciding the names of the institutions that will be the initial direct\plain\cf1\f51\fs20\ql holders.{\*\bkmkstart toc357361_12_11558912}{\*\bkmkend toc357361_12_11558912}\par\pard\plain\sb528\cf1\f51\fs20\b\qc PLAN OF DISTRIBUTION\par\pard\plain\sb264\fi462\cf1\f51\fs20\ql We may sell the securities to or through underwriters or dealers, through agents, or directly to one or more purchasers. A\plain\cf1\f51\fs20\ql prospectus supplement or supplements (and any related free writing prospectus that we may authorize to be provided to you) will\plain\cf1\f51\fs20\ql describe the terms of the offering of the securities, including, to the extent applicable:\par\pard\plain\cf1\f51\fs12\ql \~
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{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql the name or names of any agents or underwriters;\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248\row}}}\pard\plain\cf1\f51\fs12\ql \~
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{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql the purchase price of the securities being offered and the proceeds we will receive from the sale;\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248\row}}}\pard\plain\cf1\f51\fs12\ql \~
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{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql any over-allotment options under which underwriters may purchase additional securities from us;\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248\row}}}\pard\plain\cf1\f51\fs12\ql \~
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{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh495
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql any agency fees or underwriting discounts and other items constituting agents\u8217? or underwriters\u8217?\plain\intbl\cf1\f51\fs20\ql compensation;\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh495\row}}}\pard\plain\cf1\f51\fs12\ql \~
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{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql any public offering price;\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248\row}}}\pard\plain\cf1\f51\fs12\ql \~
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{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql any discounts or concessions allowed or reallowed or paid to dealers; and\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248\row}}}\pard\plain\cf1\f51\fs12\ql \~
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{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql any securities exchanges or markets on which such securities may be listed.\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248\row}}}\pard\plain\sb264\fi462\cf1\f51\fs20\ql We may distribute the securities from time to time in one or more transactions at:\par\pard\plain\cf1\f51\fs12\ql \~
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{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql fixed price or prices, which may be changed from time to time;\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248\row}}}\pard\plain\cf1\f51\fs12\ql \~
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{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql market prices prevailing at the time of sale;\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248\row}}}\pard\plain\cf1\f51\fs12\ql \~
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{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql prices related to such prevailing market prices; or\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248\row}}}\pard\plain\cf1\f51\fs12\ql \~
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{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql negotiated prices.\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh248\row}}}\pard\plain\li88\sb396\cf1\f51\fs20\b\i\ql Agents\par\pard\plain\sb132\fi462\cf1\f51\fs20\ql We may designate agents who agree to use their reasonable efforts to solicit purchases of our securities for the period of\plain\cf1\f51\fs20\ql their appointment or to sell our securities on a continuing basis. We will name any agent involved in the offering and sale of\plain\cf1\f51\fs20\ql securities and we will describe any fees or commissions we will pay the agent in the applicable prospectus supplement.\par\pard\plain\li88\sb396\cf1\f51\fs20\b\i\ql Underwriters\par\pard\plain\sb132\fi462\cf1\f51\fs20\ql If we use underwriters for a sale of securities, the underwriters will acquire the securities for their own account. The\plain\cf1\f51\fs20\ql underwriters may resell the securities in one or more transactions, including negotiated transactions,\par\pard\plain\cf1\f51\fs16\ql \~\par\pard\plain\cf1\f51\fs20\qc 24
\page\par\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par\par\pard\plain\ul{\field{\*\fldinst HYPERLINK \\l "toc_11558912" }{\*\fldrslt\cf3\f52\fs16\b\ql Table of Contents}}\par\pard\plain\cf1\f51\fs20\ql at a fixed public offering price or at varying prices determined at the time of sale. The obligations of the underwriters to\plain\cf1\f51\fs20\ql purchase the securities will be subject to the conditions set forth in the applicable underwriting agreement. Subject to certain\plain\cf1\f51\fs20\ql conditions, the underwriters will be obligated to purchase all the securities of the series offered if they purchase any of the\plain\cf1\f51\fs20\ql securities of that series. We may change from time to time any public offering price and any discounts or concessions the\plain\cf1\f51\fs20\ql underwriters allow or reallow or pay to dealers. We may use underwriters with whom we have a material relationship. We will\plain\cf1\f51\fs20\ql describe the nature of any such relationship in any applicable prospectus supplement naming any such underwriter. Only\plain\cf1\f51\fs20\ql underwriters we name in the prospectus supplement are underwriters of the securities offered by the prospectus supplement.\par\pard\plain\sb264\fi462\cf1\f51\fs20\ql We may provide agents and underwriters with indemnification against civil liabilities related to offerings under this\plain\cf1\f51\fs20\ql prospectus, including liabilities under the Securities Act, or contribution with respect to payments that the agents or underwriters\plain\cf1\f51\fs20\ql may make with respect to these liabilities.\par\pard\plain\li88\sb396\cf1\f51\fs20\b\i\ql Direct Sales\par\pard\plain\sb132\fi462\cf1\f51\fs20\ql We may also sell securities directly to one or more purchasers without using underwriters or agents. Underwriters, dealers\plain\cf1\f51\fs20\ql and agents that participate in the distribution of the securities may be underwriters as defined in the Securities Act, and any\plain\cf1\f51\fs20\ql discounts or commissions they receive from us and any profit on their resale of the securities may be treated as underwriting\plain\cf1\f51\fs20\ql discounts and commissions under the Securities Act. We will identify in the applicable prospectus supplement any underwriters,\plain\cf1\f51\fs20\ql dealers or agents and will describe their compensation. We may have agreements with the underwriters, dealers and agents to\plain\cf1\f51\fs20\ql indemnify them against specified civil liabilities, including liabilities under the Securities Act. Underwriters, dealers and agents\plain\cf1\f51\fs20\ql may engage in transactions with or perform services for us in the ordinary course of their businesses.\par\pard\plain\li88\sb396\cf1\f51\fs20\b\i\ql Trading Markets and Listing of Securities\par\pard\plain\sb132\fi462\cf1\f51\fs20\ql Unless otherwise specified in the applicable prospectus supplement, each class or series of securities will be a new issue\plain\cf1\f51\fs20\ql with no established trading market, other than our common stock, which is currently listed on the NYSE MKT. We may elect to\plain\cf1\f51\fs20\ql list any other class or series of securities on any exchange or market, but we are not obligated to do so. It is possible that one or\plain\cf1\f51\fs20\ql more underwriters may make a market in a class or series of securities, but the underwriters will not be obligated to do so and\plain\cf1\f51\fs20\ql may discontinue any market making at any time without notice. We cannot give any assurance as to the liquidity of the trading\plain\cf1\f51\fs20\ql market for any of the securities.\par\pard\plain\li88\sb396\cf1\f51\fs20\b\i\ql Stabilization Activities\par\pard\plain\sb132\fi462\cf1\f51\fs20\ql Any underwriter may engage in overallotment, stabilizing transactions, short covering transactions and penalty bids in\plain\cf1\f51\fs20\ql accordance with Regulation M under the Exchange Act. Overallotment involves sales in excess of the offering size, which create\plain\cf1\f51\fs20\ql a short position. Stabilizing transactions permit bids to purchase the underlying security so long as the stabilizing bids do not\plain\cf1\f51\fs20\ql exceed a specified maximum. Short covering transactions involve purchases of the securities in the open market after the\plain\cf1\f51\fs20\ql distribution is completed to cover short positions. Penalty bids permit the underwriters to reclaim a selling concession from a\plain\cf1\f51\fs20\ql dealer when the securities originally sold by the dealer are purchased in a covering transaction to cover short positions. Those\plain\cf1\f51\fs20\ql activities may cause the price of the securities to be higher than it would otherwise be. If commenced, the underwriters may\plain\cf1\f51\fs20\ql discontinue any of these activities at any time.\par\pard\plain\li88\sb396\cf1\f51\fs20\b\i\ql Passive Market Making\par\pard\plain\sb132\fi462\cf1\f51\fs20\ql Any underwriters who are qualified market makers on the NYSE MKT may engage in passive market making transactions\plain\cf1\f51\fs20\ql in the securities on the NYSE MKT in accordance with Rule 103 of Regulation M, during the business day prior to the pricing\plain\cf1\f51\fs20\ql of the offering, before the commencement of offers or sales of the securities. Passive market makers must comply with applicable\plain\cf1\f51\fs20\ql volume and price limitations and must be identified as passive market makers. In general, a passive market maker must display\plain\cf1\f51\fs20\ql its bid at a price not in excess of the\par\pard\plain\cf1\f51\fs16\ql \~\par\pard\plain\cf1\f51\fs20\qc 25
\page\par\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par\par\pard\plain\ul{\field{\*\fldinst HYPERLINK \\l "toc_11558912" }{\*\fldrslt\cf3\f52\fs16\b\ql Table of Contents}}\par\pard\plain\cf1\f51\fs20\ql highest independent bid for such security. If all independent bids are lowered below the passive market maker\u8217?s bid,\plain\cf1\f51\fs20\ql however, the passive market maker\u8217?s bid must then be lowered when certain purchase limits are exceeded.{\*\bkmkstart toc357361_13_11558912}{\*\bkmkend toc357361_13_11558912}\par\pard\plain\sb528\cf1\f51\fs20\b\qc LEGAL MATTERS\par\pard\plain\sb264\fi462\cf1\f51\fs20\ql The validity of the securities being offered by this prospectus will be passed upon for us by DLA Piper LLP (US), San\plain\cf1\f51\fs20\ql Diego, California. If the validity of any securities is also passed upon by counsel any underwriters, dealers or agents, that counsel\plain\cf1\f51\fs20\ql will be named in the prospectus supplement relating to that specific offering.{\*\bkmkstart toc357361_14_11558912}{\*\bkmkend toc357361_14_11558912}\par\pard\plain\sb528\cf1\f51\fs20\b\qc EXPERTS\par\pard\plain\sb264\fi462\cf1\f51\fs20\ql The consolidated financial statements incorporated in this prospectus by reference to the Annual Report on Form 10-K for\plain\cf1\f51\fs20\ql the year ended December\~31, 2014 have been so incorporated in reliance on the report of PricewaterhouseCoopers LLP, an\plain\cf1\f51\fs20\ql independent registered public accounting firm, given on the authority of such firm as experts in auditing and accounting.{\*\bkmkstart toc357361_15_11558912}{\*\bkmkend toc357361_15_11558912}\par\pard\plain\sb528\cf1\f51\fs20\b\qc INFORMATION INCORPORATED BY REFERENCE\par\pard\plain\sb264\fi462\cf1\f51\fs20\ql The SEC allows us to \u8220?incorporate by reference\u8221? into this prospectus the information we file with the SEC.\plain\cf1\f51\fs20\ql This means that we can disclose important information to you by referring you to those documents. Any statement contained in a\plain\cf1\f51\fs20\ql document incorporated by reference in this prospectus shall be deemed to be modified or superseded for purposes of this\plain\cf1\f51\fs20\ql prospectus to the extent that a statement contained herein, or in any subsequently filed document, which also is incorporated by\plain\cf1\f51\fs20\ql reference herein, modifies or supersedes such earlier statement. Any such statement so modified or superseded shall not be\plain\cf1\f51\fs20\ql deemed, except as so modified or superseded, to constitute a part of this prospectus.\par\pard\plain\sb264\fi462\cf1\f51\fs20\ql We hereby incorporate by reference into this prospectus the following documents that we have filed with the SEC under the\plain\cf1\f51\fs20\ql Exchange Act File No.\~001-32157 (other than current reports on Form 8-K, or portions thereof, furnished under Items\~2.02 or\plain\cf1\f51\fs20\ql 7.01 of Form\~8-K):\par\pard\plain\cf1\f51\fs12\ql \~
\par\pard\plain
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\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql our Annual Report on Form 10-K for the fiscal year ended December\~31, 2014, filed with the SEC on March\~24,\plain\intbl\cf1\f51\fs20\ql 2015;\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh495\row}}}\pard\plain\cf1\f51\fs12\ql \~
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{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh495
\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql our Current Reports on Form 8-K filed with the SEC on January\~6, 2015,\~January\~7, 2015,\~January\~12,\plain\intbl\cf1\f51\fs20\ql 2015,\~January\~27, 2015,\~February\~3, 2015,\~February\~9, 2015, and March\~2, 2015; and\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh495\row}}}\pard\plain\cf1\f51\fs12\ql \~
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\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \u8226?\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql the description of our common stock contained in our registration statement on Form 8-A filed with the SEC on\plain\intbl\cf1\f51\fs20\ql April\~27, 2004 (File No.\~001-32157-04755401).\cell{
{\trowd\clvertalc\cellx540\cellx1204\cellx1311\cellx10800\trrh495\row}}}\pard\plain\sb264\fi462\cf1\f51\fs20\ql All documents that we file with the SEC pursuant to Section\~13(a), 13(c), 14 or 15(d) of the Exchange Act (other than\plain\cf1\f51\fs20\ql current reports on Form 8-K, or portions thereof, furnished under Items 2.02 or 7.01 of Form 8-K) (i)\~after the initial filing date\plain\cf1\f51\fs20\ql of the registration statement of which this prospectus forms a part and prior to the effectiveness of such registration statement and\plain\cf1\f51\fs20\ql (ii)\~after the date of this prospectus and prior to the termination of the offering shall be deemed to be incorporated by reference\plain\cf1\f51\fs20\ql in this prospectus from the date of filing of the documents, unless we specifically provide otherwise. Information that we file\plain\cf1\f51\fs20\ql with the SEC will automatically update and may replace information previously filed with the SEC. To the extent that any\plain\cf1\f51\fs20\ql information contained in any current report on Form 8-K or any exhibit thereto, was or is furnished to, rather than filed with the\plain\cf1\f51\fs20\ql SEC, such information or exhibit is specifically not incorporated by reference.\par\pard\plain\cf1\f51\fs16\ql \~\par\pard\plain\cf1\f51\fs20\qc 26
\page\par\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par\par\pard\plain\ul{\field{\*\fldinst HYPERLINK \\l "toc_11558912" }{\*\fldrslt\cf3\f52\fs16\b\ql Table of Contents}}\par\pard\plain\fi462\cf1\f51\fs20\ql Upon written or oral request made to us at the address or telephone number below, we will, at no cost to the requester,\plain\cf1\f51\fs20\ql provide to each person, including any beneficial owner, to whom this prospectus is delivered, a copy of any or all of the\plain\cf1\f51\fs20\ql information that has been incorporated by reference in this prospectus (other than an exhibit to a filing, unless that exhibit is\plain\cf1\f51\fs20\ql specifically incorporated by reference into that filing), but not delivered with this prospectus. You may also access this\plain\cf1\f51\fs20\ql information on our website at www.masttherapeutics.com by viewing the \u8220?SEC Filings\u8221? subsection of the\plain\cf1\f51\fs20\ql \u8220?Investors\u8221? menu. No additional information on our website is deemed to be part of or incorporated by reference\plain\cf1\f51\fs20\ql into this prospectus. We have included our website address in this prospectus solely as an inactive textual reference.\par\pard\plain\sb264\cf1\f51\fs20\qc Mast Therapeutics, Inc.\par\pard\plain\cf1\f51\fs20\qc 3611 Valley Centre Drive, Suite 500\par\pard\plain\cf1\f51\fs20\qc San Diego, CA 92130 Attn: Investor Relations\par\pard\plain\cf1\f51\fs20\qc (858) 552-0866{\*\bkmkstart toc357361_16_11558912}{\*\bkmkend toc357361_16_11558912}\par\pard\plain\sb528\cf1\f51\fs20\b\qc WHERE YOU CAN FIND MORE INFORMATION\par\pard\plain\sb264\fi462\cf1\f51\fs20\ql As permitted by SEC rules, this prospectus omits certain information that is included in the registration statement of which\plain\cf1\f51\fs20\ql this prospectus forms a part and its exhibits. Since this prospectus may not contain all of the information that you may find\plain\cf1\f51\fs20\ql important, you should review the full text of these documents. If we have filed a contract, agreement or other document as an\plain\cf1\f51\fs20\ql exhibit to the registration statement of which this prospectus forms a part, you should read the exhibit for a more complete\plain\cf1\f51\fs20\ql understanding of the document or matter involved. Each statement in this prospectus, including statements incorporated by\plain\cf1\f51\fs20\ql reference as discussed above, regarding a contract, agreement or other document is qualified in its entirety by reference to the\plain\cf1\f51\fs20\ql actual document.\par\pard\plain\sb264\fi462\cf1\f51\fs20\ql We are subject to the information reporting requirements of the Exchange Act, and, in accordance with these requirements,\plain\cf1\f51\fs20\ql we file annual, quarterly and current reports, proxy statements, and other information with the SEC. You may inspect, read and\plain\cf1\f51\fs20\ql copy the reports and other information we file with the SEC at the SEC\u8217?s Public Reference Room located at 100 F Street,\plain\cf1\f51\fs20\ql N.E., Washington, D.C. You may obtain information on the operation of the Public Reference Room by calling the SEC at\plain\cf1\f51\fs20\ql 1-800-SEC-0330. The SEC also maintains an internet website at http://www.sec.gov that contains our filed reports, proxy and\plain\cf1\f51\fs20\ql information statements, and other information that we file electronically with the SEC. Additionally, we make these filings\plain\cf1\f51\fs20\ql available, free of charge, on our website at www.masttherapeutics.com in the \u8220?SEC Filings\u8221? subsection of the\plain\cf1\f51\fs20\ql \u8220?Investors\u8221? menu as soon as reasonably practicable after we electronically file such materials with, or furnish them\plain\cf1\f51\fs20\ql to, the SEC. The information on our website, other than these filings, is not, and should not be, considered part of this\plain\cf1\f51\fs20\ql prospectus, is not incorporated by reference into this prospectus, and should not be relied upon in connection with making any\plain\cf1\f51\fs20\ql investment decision with respect to our securities.\par\pard\plain\cf1\f51\fs16\ql \~\par\pard\plain\cf1\f51\fs20\qc 27
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\par\pard\plain\sb396\cf1\f51\fs32\b\qc $18,000,000\par\pard\plain\sb396\cf1\f51\fs28\b\qc Common Stock\par\pard\plain\cf1\f51\fs24\ql \~\par\pard\plain\brdrb\brdrs\sa44\cf1\f51\fs20\qc \~\par\pard\plain\sb264\cf1\f51\fs24\b\qc PROSPECTUS SUPPLEMENT\par\pard\plain\cf1\f51\fs24\ql \~\par\pard\plain\brdrb\brdrs\sa44\cf1\f51\fs20\qc \~\par\pard\plain\sb264\cf1\f51\fs36\b\qc H.C. Wainwright\~& Co.\par\pard\plain\cf1\f51\fs24\ql \~\par\pard\plain\brdrb\brdrs\sa44\cf1\f51\fs20\qc \~\par\pard\plain\sb264\cf1\f51\fs20\b\qc May\~1, 2017\par\pard\plain\cf1\f51\fs144\ql \~\par\pard\plain\cf1\f51\fs144\ql \~\par\pard\plain\brdrb\brdrs\cf1\f51\fs20\ql \~\par\pard\plain\brdrb\brdrs\sa44\cf1\f51\fs20\ql \~}