Article Figures & Data

Figures

The figure shows two faces (inspired by the two-faced Janus god) that represent two cells. On the left is a wild-type cell with normal Bearded function, and on the right is a Bearded mutant cell. In the wild-type cell, the presence of Bearded leads to a polarized cell with normal morphology with Crb in the subapical region. Crb binds to Sdt (both the Sdt-PF and Sdt-PB isoforms), and this leads to stabilization of the Sdt protein and thus apical enrichment of Crb. In contrast, in the Bearded mutant cell (represented by the lack of a beard), neuralized is hyperactive, which in turn results in reduction of Sdt-PB and Crb from the apical membrane and thus compromises the morphology of this cell.