Mechanism of the cardioprotective effect of inhibition of the renin-angiotensin system on ischemia/reperfusion-induced myocardial injury.

@article{Wang2001MechanismOT,
title={Mechanism of the cardioprotective effect of inhibition of the renin-angiotensin system on ischemia/reperfusion-induced myocardial injury.},
author={Lijie Wang and Munehito Ideishi and Eiji Yahiro and Hidenori Urata and Kikuo Arakawa and Keijiro Saku},
journal={Hypertension research : official journal of the Japanese Society of Hypertension},
year={2001},
volume={24 2},
pages={179-87}
}

Inhibition of the renin-angiotensin system (RAS) has been shown to be beneficial in providing cardioprotective effects in humans, but the mechanism of these effects is not well understood. In this study, we examined the effects and mechanism of RAS inhibitors on ischemia/reperfusion (IR)-induced myocardial injury in rats. Rats were randomly divided into five groups and treated with vehicle (C), angiotensin converting enzyme inhibitor (ACE-I), angiotensin II type 1 receptor antagonist (AT1-A… CONTINUE READING