The ready-to-use lentiviral particles of Lenti-FRα (Folate receptor-alpha)(Folate receptor-alpha) CAR (scFv-ζ, MOv19)-VP is packaged using 3rd generation of lentiviral packaging system, in which the gene of CAR will be driven by a CMV promotor. The target gene of scFv (MOv19)-CD3ζ packaged in lentiviral particles could be used for high efficency tranduction of T cells and stably integrated expression.

Specifications

Type of Therapeutics

Chimeric Antigen Receptor

Target

FRα (Folate receptor-alpha)

Expression Cassette

scFv (MOv19)-CD3ζ

Clone

MOv19

Promotor

CMV

Packaging System

Lentivirus

Packaging Cell

293T

Targeting Diseases

FRα (Folate receptor-alpha)positive human cancers

Target

Introduction

The protein encoded by this gene is a member of the folate receptor family. Members of this gene family bind folic acid and its reduced derivatives, and transport 5-methyltetrahydrofolate into cells. This gene product is a secreted protein that either anchors to membranes via a glycosyl-phosphatidylinositol linkage or exists in a soluble form. Mutations in this gene have been associated with neurodegeneration due to cerebral folate transport deficiency. Due to the presence of two promoters, multiple transcription start sites, and alternative splicing, multiple transcript variants encoding the same protein have been found for this gene.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.