Seven of Nine discovered that the Borg had received a distress call from the cube, but had determined the children to be irrelevant and had not dispatched any other ships to reconnect them to the hive mind. After the children realized this, they decided to leave the cube. (VOY: "Collective") She would later recall feeling afraid and alone upon her disconnection. (VOY: "The Haunting of Deck Twelve")

After her implants were removed, Mezoti slowly regained her individuality with the help of Seven of Nine and fellow former drone children Icheb, Azan and Rebi. Freed from Borg influence, her creative, fun side came out; she enjoyed sculpting. She once offered to show Naomi Wildman how to braid her hair like hers, a conversation Seven initially considered irrelevant while engaging in an hour of "recreational activity". (VOY: "Ashes to Ashes") Mezoti also had an interest in insects. (VOY: "Child's Play")

In 2376, Mezoti disobeyed instructions to wait in the cargo bay until Seven of Nine returned, choosing instead to go to the astrometrics lab. There, she received a call from Lyndsay Ballard, a former Voyager crew member who had died and was later revived by the Kobali. In an attempt to reroute the call to Kathryn Janeway, she ended the transmission instead. When discovered by Tuvok and Seven, she tried to re-establish contact with Ballard, which temporarily distracted them from disciplining her.

Later, she completed a science project involving a Teirenian antcolony. Several days later, Mezoti was unable to regenerate as she missed Icheb, who had returned to his parents Leucon and Yifay. She then helped Seven to realize that Icheb's parents were lying about the circumstances of his assimilation and that they had ulterior motives in welcoming him home. (VOY: "Child's Play")

Voyager was unable to contact the Norcadians, but were successful in locating Azan and Rebi's people, the Wysanti, in 2377. The Wysanti agreed to give Mezoti a home with the twins. Prior to her leaving, she studied information on their culture. Upon leaving Voyager, she hugged Seven, saying she preferred the Human way of saying goodbye to Wysanti tradition, in which it was not customary to say goodbye. (VOY: "Imperfection")