When a guy gets hurt in a relationship and he aggressively tries to bang as many girls (typically bar skanks) as he can in an attempt to move on and hide from the pain/humiliation of the breakup. It is often paired with excessive alcohol/drug abuse in a dangerous combination of self-destructive behaviour. The term comes from various shooter games where a player comes out much more reckless than usual after being killed in embarrassing fashion.

"Man, Steve hasn't been to class in 2 weeks and he never returns anyone's texts anymore"
"Yeah, after Chelsea broke up with him, all he does is go to the bar and try to wheel the dustiest chicks"
"Yeah dude, he's on a total killing spree"