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TCRsafe™: Find the detailed structures in T-cell repertoires

TCRsafe™: Get the overview, get the right perspective

TCRsafe™: Get to the sequence space of TCRs, base by base

HS Diagnomics

is a Berlin based company founded in 2012. We are specialists in T-cell beta receptor (TCRbeta / CDR3) profiling by ultra-deep sequencing. With our proprietary technology, tested and optimized in hundreds of samples, we can display the T-cell beta repertoire in blood and tissue samples in maximal resolution, up to the single cell level and up to every single nucleotide and translated peptide of the TCR. Within days our customers will receive an atomic view on TCRbeta profiles, a key to understanding of the adaptive immune system. Moreover, our TCRsafe procedure allows the simultaneous analysis of cohorts of samples, with detailed overlap analysis – a cutting-edge tool for systematic studies of the adaptive immune system.

Our mission

and our offer to the market is a robust and integrated service to explore TCRbeta profiles in yet unprecedented resolution. Our customers send us the samples, the rest of the procedure is with us. Our experienced team of molecular biologists, technicians and bioinformaticians will deliver TCRbeta-profiles comprising thousands of clonotypes, which are characterized base by base of their CDR3 regions. All results are displayed in compact tables which can be easily managed by customers locally, detailed reports will document every relevant result of our analysis. We believe that our T-cell profiling technology will open a new field of diagnostics and medicine, with key features of individual immune systems being uncovered.

Our technology

is based on a multistep PCR-amplification with proprietary primer systems, which amplify TCRbeta specific regions directly from genomic DNA. With an inbuilt 2-fold contamination protection our TCRsafe protocol is superior to other technologies, since it eliminates spurious intake of alien samples very efficiently. Following state of the art deep-sequencing HSDiagnomics uses in-house developed bioinformatics tools to condense million of raw sequence reads into clusters (clonotypes).