Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )

Length:

103

Sequences:

635

Seq/Len:

6.17

HH_delta:

0.847 (20Jul13)

GREMLIN Results:
Residue pairs sorted by strength in covariance:Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

i

j

Raw Score

Scaled Score

23_G

72_F

0.36608

3.323

16_L

38_F

0.30525

2.771

36_I

43_I

0.26906

2.442

45_H

82_T

0.25649

2.328

55_G

58_A

0.25475

2.312

34_G

48_S

0.18904

1.716

96_R

100_E

0.17363

1.576

12_L

68_G

0.16715

1.517

34_G

58_A

0.16347

1.484

17_E

88_E

0.16049

1.457

72_F

75_D

0.15914

1.444

15_L

70_F

0.15629

1.419

45_H

55_G

0.15613

1.417

34_G

55_G

0.1468

1.332

11_D

19_S

0.14338

1.301

63_L

94_A

0.13854

1.257

92_L

99_D

0.13642

1.238

69_T

75_D

0.13584

1.233

12_L

70_F

0.13557

1.231

7_F

15_L

0.13527

1.228

25_L

72_F

0.13413

1.217

59_L

90_L

0.1332

1.209

14_Q

92_L

0.13169

1.195

65_W

93_E

0.12716

1.154

46_A

55_G

0.12696

1.152

29_S

32_G

0.12547

1.139

21_K

72_F

0.12495

1.134

6_D

101_W

0.12487

1.133

60_F

93_E

0.123

1.116

10_P

22_T

0.12271

1.114

6_D

27_V

0.1213

1.101

14_Q

53_L

0.12064

1.095

9_L

62_L

0.12053

1.094

59_L

94_A

0.12002

1.089

22_T

41_G

0.11829

1.074

14_Q

21_K

0.11789

1.070

19_S

70_F

0.11737

1.065

45_H

79_E

0.11696

1.062

12_L

72_F

0.11691

1.061

31_G

37_Y

0.11622

1.055

35_R

98_L

0.11541

1.048

52_R

85_L

0.11504

1.044

7_F

70_F

0.11343

1.030

34_G

45_H

0.11321

1.028

34_G

62_L

0.11225

1.019

55_G

85_L

0.11205

1.017

12_L

87_T

0.11063

1.004

40_D

64_S

0.1098

0.997

94_A

97_R

0.10964

0.995

34_G

82_T

0.10929

0.992

53_L

61_E

0.1077

0.978

62_L

89_E

0.10718

0.973

79_E

82_T

0.10705

0.972

23_G

38_F

0.10636

0.965

55_G

87_T

0.10267

0.932

19_S

23_G

0.10232

0.929

48_S

58_A

0.1022

0.928

17_E

87_T

0.1019

0.925

59_L

67_E

0.10137

0.920

29_S

38_F

0.10065

0.914

47_S

52_R

0.10062

0.913

89_E

93_E

0.10011

0.909

31_G

73_E

0.0998

0.906

71_E

86_S

0.09863

0.895

13_L

38_F

0.0966

0.877

31_G

67_E

0.09629

0.874

34_G

65_W

0.09582

0.870

29_S

65_W

0.09579

0.869

92_L

95_L

0.09491

0.861

92_L

100_E

0.0948

0.860

13_L

17_E

0.09475

0.860

46_A

77_P

0.0944

0.857

10_P

94_A

0.09384

0.852

53_L

71_E

0.09348

0.848

13_L

59_L

0.09304

0.844

60_F

64_S

0.09295

0.844

37_Y

45_H

0.09289

0.843

12_L

15_L

0.09244

0.839

34_G

46_A

0.09244

0.839

46_A

58_A

0.09242

0.839

10_P

35_R

0.09185

0.834

43_I

70_F

0.09169

0.832

48_S

81_R

0.09132

0.829

20_R

93_E

0.09107

0.827

47_S

71_E

0.09081

0.824

19_S

22_T

0.09071

0.823

36_I

86_S

0.09041

0.821

47_S

53_L

0.09016

0.818

63_L

91_L

0.09016

0.818

11_D

35_R

0.08995

0.816

22_T

60_F

0.0897

0.814

34_G

49_G

0.08966

0.814

33_E

56_E

0.08957

0.813

33_E

77_P

0.08953

0.813

17_E

42_R

0.08936

0.811

37_Y

95_L

0.08927

0.810

16_L

21_K

0.08924

0.810

30_G

33_E

0.08921

0.810

73_E

93_E

0.0884

0.802

63_L

66_K

0.0882

0.801

43_I

77_P

0.08817

0.800

75_D

86_S

0.08802

0.799

8_S

24_V

0.08794

0.798

12_L

28_Q

0.08781

0.797

24_V

87_T

0.08715

0.791

66_K

71_E

0.08679

0.788

33_E

67_E

0.08657

0.786

48_S

52_R

0.08653

0.785

27_V

33_E

0.08647

0.785

55_G

82_T

0.08638

0.784

66_K

80_P

0.086

0.781

39_R

56_E

0.08597

0.780

6_D

78_P

0.08565

0.777

13_L

87_T

0.08538

0.775

30_G

65_W

0.08533

0.775

47_S

56_E

0.08528

0.774

86_S

89_E

0.08512

0.773

76_P

91_L

0.08493

0.771

13_L

55_G

0.08485

0.770

14_Q

94_A

0.08474

0.769

9_L

36_I

0.08439

0.766

47_S

66_K

0.08418

0.764

43_I

76_P

0.08406

0.763

31_G

80_P

0.0839

0.762

75_D

97_R

0.0836

0.759

13_L

60_F

0.08352

0.758

61_E

101_W

0.0835

0.758

17_E

65_W

0.0834

0.757

22_T

76_P

0.08321

0.755

27_V

74_P

0.08293

0.753

57_E

64_S

0.08277

0.751

61_E

64_S

0.08255

0.749

27_V

54_Q

0.08241

0.748

36_I

91_L

0.08177

0.742

9_L

35_R

0.08149

0.740

37_Y

73_E

0.08119

0.737

58_A

61_E

0.08117

0.737

34_G

63_L

0.08114

0.736

21_K

70_F

0.08103

0.735

49_G

61_E

0.08098

0.735

23_G

87_T

0.08067

0.732

Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.

HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits: Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)