Melbourne's "sophisticated, stylish, and free-spirited" vibes gave it the edge on Sydney, which was placed at No.6 on the list - and left some of the world's most travelled destinations lagging behind.

"Melbourne has all of the traits you'd want in a friend - and an incredible arts scene," the listing gushes.

And it's not just the CBD laneways and regular tourist haunts that get the nod, with Conde Nast Traveler directing visitors to the lesser-known areas of Preston (of Courtney Barnett "Depreston" fame) and the quiet northeastern suburb of Bulleen.