Farcotilium (domperidone) is an eUactive antiemehc ~nd Gas1roprokt\etic agent for treatment of necsee, vomItIng and other dyspeptIC symptoms ecceted WIth delayed gastnc emptyng and gaslroesophageal reflux FARCOTIUUM IS a selectIVe per1>heral dopanllne antagonist at the raceplors It stimulates copee GI motility, increases the Iowor esophageal sphincter pressure, promotes esophageal and antral ccntrectens. relaxes. pyloric sphincter and ncreases duodenal and j8J16\41 peretetsre. The over allefleclof FARCOTlUUMIS prevenllOnol gastroesophageal rel1ux, acceleration 01 gastric emptYing and reduction 01 the transit tene 01 Intestmal contants from the duodenum 10 ueccecet valve Clinically, F~RCOTllIUM therapy corrects dISturbances of GI molitity with prompt reliel of associated eructation, flatulence, heartburn and abdominal deccmtcrt fAACOTIUUM has no eflecl on
Gl secretions or colonic motiLly and does not cause diarrhea Also, FARCOTIUUM does not cross the blood-brain barrier, so its use 11 the treatment of nausea and ,vomrting does not cause .the psychotropic or
suit pahoots of all age groups underdifferoot condltlOOS

Pharmacokinetics :

Following FARCOTIUUM administratio.n, domperidone is rapidly absorbed from the GIT, Presystemic metabolism occurs in the gut wall and liver, Peak plasma ccnceotretcns are achieved within 30 minutes of oral administration and after about one hour following rectal administration Domperidone is distributed into most body tissues end Iluds but does not cross the blood-brain barrier, More than 90 % of the drug is is about 7,5 hours

A1thoug, aninal studies did not demonstrate any t8f’Zltogonie effect on the letus, domperiOOne should be used dumg pregnancy under medical supervision, Dompendone may Improve postnalallactation and its secretion In breast mdk IS very smaH and insufficient to cause hann to the baby

Drug Interactions:

Domperidone antagonizes the hypoprolactnemie effect of bromocrcune The effect 01 domperidone on GI motility may be anta~ized by antimuscarinies an~ opiOid analg~ies Domperidone may enhance the ebsorpton of concomitantly
aaninistered drugs particuiarty in patients with delayed gastric emptying