Cellular crosstalk contributes to asthma, pulmonary hypertension

Washington, Aug 18 (ANI): Crosstalk between cells lining the lung (epithelial cells) and airway smooth muscle cells could be linked to lung diseases, such as asthma and pulmonary hypertension.

Already, it is known that such crosstalk is important in lung development.

Researchers at the University of Pennsylvania, Philadelphia, have now molecularly characterized one crosstalk pathway in mice, which could provide potential new therapeutic targets for treating individuals with lung diseases, such as asthma and pulmonary hypertension, which are caused, at least in part, by affects on airway smooth muscle cells.

The team, led by Edward Morrisey and Ethan David Cohen, used numerous in vivo gain- and loss-of-function approaches to demonstrate that a Wnt7b/Tnc/Pdgfr crosstalk pathway was important for mouse smooth muscle development.