A "modern" disease of humans may have been what sickened ancient Nubian cultures, research on more than 200 mummies has found. The mummies were infected by a parasitic worm associated with irrigation ditches.

The disease, called schistosomiasis, is contracted through the skin when a person comes into contact with worm-infested waters. The disease infects over 200 million people worldwide a year; once contracted, the disease causes a rash, followed by fever, chills, cough and muscle aches. If infection goes untreated, it can damage the liver, intestines, lungs and bladder.

The species of Schistosoma worm, called S. mansoni, found to be prevalent in the Nubian mummies had been thought of as a more recent agent of disease, linked to urban life and stagnant water in irrigation ditches.

"It is the one most prevalent in the delta region of Egypt now, and researchers have always assumed that it was a more recent pathogen, but now we show that goes back thousands of years," said study researcher George Armelagos of Emory University in Atlanta.

CDC

This diagram shows the lifecycle of the Schistosomiasis parasite.

Although Armelagos and his colleagues weren't able to discern how bad the infections were in these Nubians, they said those who were infected would have felt run down — which would have affected their work (mostly farming).

Modern S. mansoni
Previous research showed that mummies from the Nile River region had been infected by Schistosoma worms, though new techniques are allowing researchers to determine which species.

The team tested tissue from mummies from two Nubian populations (in the area now known as Sudan), dating from 1,200 and 1,500 years ago, respectively.

The earlier population, the Kulubnarti, lived at a time when their civilization's lifeblood, the Nile River, was at a high point, and there is little evidence of irrigation. They "probably weren't practicing irrigation; they were allowing the annual floods of the Nile to fertilize the soil," Armelagos told LiveScience.

The later population, the Wadi Halfa, lived a little farther south along the river and at a time when the water levels were lower; archaeological evidence indicates canal irrigation was in use to water crops.

The researchers expected each population would have shown signs of distinct species of Schistosomiasis; for example, S. mansoni thrives in stagnant water, while Schistosoma haematobium, another species that can infect humans, lives in flowing waters. (The team specifically looked for the antigens, proteins associated with the parasite, as well as the body's response molecules, antibodies.)

Irrigation issues
Here's what they found: About 25 percent of the 46 Wadi Halfa mummies tested were infected with S. mansoni, while only 9 percent of the Kulubnarti (191 individuals tested) were.

"In the past everyone has assumed S. haematobiumwas the source of the infection, and this study shows it was S. mansoni," Armelagos said.

The two populations also probably were infected with S. haematobium, said the researchers, who didn't test for its presence.

The irrigation canals built by the Wadi Halfa are the most likely source of the S. mansoni parasite, the researchers said. The Wadi Halfa probably contracted the disease when they used the canals to wash their clothes as well as flood the fields.

The study was published in the June issue of the American Journal of Physical Anthropology.

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