Hi there, I wanna ask something..We know that in the intracellular destruction of fagolysosom, there are 2 ways which is dependent oxygen reaction and independent oxygen reaction.
What I wanna ask is about the NO which is prodeuced as a microbisidal agent.
In the book, I found that NO is produced by independent oxygen reaction by some reaction of the arginine-basic rich protein but, NO is also produced by the INOS (inducible nitric-acid synthase) reaction. So, what point is the correct one?? or two of them are correct??

Q: Why are chemists great for solving problems?
A: They have all the solutions.

Nitric oxide (NO) is an inorganic, gaseous free radical that carries a variety of messages between cells. Vasorelaxation, neurotransmission and cytotoxicity can all be potentiated through cellular response to NO.

NO production is generated by lysosomal NADPH oxidases and mediated by members of the nitric oxide synthase (NOS) family, one of them is iNOS, in a process known as the respiratory burst, as it is accompanied by a transient increase in oxygene consumption.

iNOS is found in a variety of cell types including macrophages, hepatocytes, synoviocytes, and smooth muscle cells. Cytokines such as interferon-gamma (IFN), tumor necrosis factor (TNF), interleukin-1 and -2, and lipopolysaccarides (LPS) cause an increase in iNOS mRNA, protein, and activity levels. Protein kinase C-stimulating agents exhibit the same effect on iNOS activity. After cytokine induction, iNOS exhibits a delayed activity response which is then followed by a significant increase in NO production over a long period of time.

victor: In a short way I can say that both processes you mentioned is a single idea: iNOS works in arginine-contained protein to produce NO by the presence of oxygene

Hey, does anyone want to answer my question???
I have a question...do you think that antibiotics beside make us cured from pathogenic bacterias, they also reduce our immune system???
If yes, can you give me some references for that?

Q: Why are chemists great for solving problems?
A: They have all the solutions.

Ozge is absolutely right. That is why most antibiotics say on the box: "Only to be used under recommandation of the physician"
This reminds me of a funny story..
I went to the pharmacy a while back to get something called codein for my cauthing(i have a very mild case of asthma, or so they think, do not need an inhailer)and the lady there said i need a perscription because they are narcotics almost as strong as morphein. I had been using them for a long time and i still use them... My doctor said that they are perfectly Ok... Still, strange thing to happen

"As a biologist, I firmly believe that when you're dead, you're dead. Except for what you live behind in history. That's the only afterlife" - J. Craig Venter

Yeah, that's true. It is normal that we use morphine, codeine, amphetamine and all kinda things in medical purpose. They are analgesia or transquilizers or things we need to anethetize patients. Of course we calculate the dose very well not to result in adverse effect e.g. addiction. But, my doctor once made a mistake on giving me the dose. I gor over-dosed on amphetamine grrr and I need to do rehabilitation or detoxication for a while But, it was a good experience, I know how to be a jonkey