Abstract

Two different type of electrodes, boron-doped diamond electrode (BDD) and boron-doped carbon nanowalls
(B:CNW) electrode, were used for the electrochemical determination of paracetamol using the cyclic voltammetry
and the differential pulse voltammetry in phosphate buffered saline, pH =7.0. The main advantage of
these electrodes is their utilization without any additional modification of the electrode surface. The peak
current was linearly related to the concentration of paracetamol in the range from 0.065 μM to 32 μM for BDD
electrode and from 0.032 μM to 32 μM for B:CNW electrode. The limit of detection was 0.430 μM and 0.281 μM
for BDD and B:CNW electrode, respectively. Additionally, we studied the effect of pH on the redox reaction of
paracetamol at the both electrodes in Britton-Robinson buffer solution in the range of pH 3.0–12.0, indicating
the pH 7.0 value as the most suitable for the current experiments. The studies also included the various scan rates
in range of 50–500 mV/s. Finally, our team selected the B:CNW electrode for the determination of paracetamol
in the artificial urine sample using differential pulse voltammetry method, obtaining the calculated limit of
detection on the level of 0.08006 μM.