Efforts to characterize the process of apoptosis, or programmed cell death, are probably one of the clearest examples to represent the inherent complexity of regulatory mechanisms and interactions between enzymes, signals and various growth factors in a cell. Among these mechanisms, the role played by the kinase p38aMAP object of interest is the group of the Faculty of Pharmacy of the Universidad Complutense de Madrid, coordinated by Almudena Porras. In a paper published in the online edition of Cell Signal, this team has characterized cell lines derived from cardiomyocytes and mouse embryonic fibroblasts deficient in p38aMAP normal, with the aim to detect different responses to the process of apoptosis. Read the rest of this entry »