Latifah performed some of her new rock-tinged hip-hop from her upcoming album, Persona, due out in July. Surprise musical guests included Dancing With the Stars contestant Lil' Kim, Missy Elliott, MC Lyte, Lady Rage and Yo-Yo.

"I just want everyone to know that I've been in the game since '89," Yo-Yo said. "Queen Latifah has never ever, ever, ever changed!"

Latifah's family—including her mom, stepdad, brother and aunt—cheered from the sidelines as a three-tier cake was rolled onto the stage by her dad.

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