FILE - In this Friday, Feb. 12, 2016 file photo, Lara, who is less then 3-months old and was born with microcephaly, is examined by a neurologist at the Pedro I hospital in Campina Grande, Paraiba state, Brazil. On Wednesday, April 13, 2016, the U.S. Centers for Disease Control and Prevention said there's enough evidence now to declare that the Zika virus during the mother's pregnancy causes the microcephaly birth defect and other brain abnormalities. (AP Photo/Felipe Dana, File)

NEW YORK (AP) — Confirming the worst fears of many pregnant women in the United States and Latin America, U.S. health officials said Wednesday there is no longer any doubt the Zika virus causes babies to be born with abnormally small heads and other severe brain defects.

Since last year, doctors in Brazil have been linking Zika infections in pregnant women to a rise in newborns with microcephaly, or an unusually small skull. Most experts were cautious about drawing a firm connection. But now the U.S. Centers for Disease Control and Prevention says enough evidence is in.

Among the evidence that clinched the case: Signs of the Zika virus, which is spread primarily through mosquito bites but can also be transmitted through sex, have been found in the brain tissue, spinal fluid and amniotic fluid of microcephaly babies.

The CDC and other health agencies have been operating for months on the assumption that Zika causes brain defects, and they have been warning pregnant women to use mosquito repellent, avoid travel to Zika-stricken regions and either abstain from sex or rely on condoms. Those guidelines will not change.

But the new finding should help officials make a more convincing case to the public for taking precautions. Some officials hope the Zika report will change public thinking about Zika the way the 1964 surgeon general’s report convinced many Americans that smoking causes lung cancer.

“We’ve been very careful over the last few months to say, ‘It’s linked to, it’s associated with.’ We’ve been careful to say it’s not the cause of,” said the CDC’s Dr. Sonja A. Rasmussen. “I think our messages will now be more direct.”

The CDC announced its conclusion in a report published online by the New England Journal of Medicine.

The World Health Organization has made similar statements recently. A WHO official applauded the CDC’s report.

“We feel it’s time to move from precautionary language to more forceful language to get people to take action,” said Dr. Bruce Aylward, who is leading WHO’s Zika response.

Zika has been sweeping through Latin America and the Caribbean in recent months, and the fear is that it will only get worse there and in the U.S. with the onset of mosquito season this spring and summer.

The virus causes only a mild and brief illness, at worst, in most people. But in the last year, infections in pregnant women have been strongly linked to fetal deaths and devastating birth defects, mostly in Brazil, where the Health Ministry said Tuesday that 1,113 cases of microcephaly have been confirmed since October.

So far, there have been no documented Zika infections in the U.S. caught from mosquitoes. Nearly 350 illnesses in the 50 states were reported as of last week, all linked to travel to Zika outbreak regions.

The report comes at a time when health officials have been begging Congress to approve an emergency request for $1.9 billion in supplemental funding to fight Zika internationally and prepare in case mosquitoes spread the virus here. Earlier on Wednesday, top House Republicans said they will probably grant a portion of that request, but probably not until September.

As the microcephaly cases rose in Latin America, a number of alternative theories circulated through the public. Some claimed the cause was a vaccine given to pregnant women. Some suspected a mosquito-killing larvicide, and others wondered whether genetically modified mosquitoes were to blame.

Investigators gradually cast these theories aside and found more and more circumstantial evidence implicating Zika.

CDC officials relied on a checklist developed by a retired University of Washington professor, Dr. Thomas Shepard. He listed seven criteria for establishing if something can be called a cause of birth defects.

They still don’t have some of the evidence they hope for. So far, for example, there have been no published studies demonstrating Zika causes such birth defects in animals. There’s also a scarcity of high-quality studies that have systematically examined large numbers of women and babies in a Zika outbreak area.

“The purist will say that all the evidence isn’t in yet, and they’re right but this is public health and we need to act,” the WHO’s Aylward said.

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