George comforts Izzie as she faces her painful past; Derek questions his relationship with Meredith while she must decide what sort of relationship she'll have with her stepmother (Mare Winningham); and Cristina decides to fight for her relationship with B (more…)George comforts Izzie as she faces her painful past; Derek questions his relationship with Meredith while she must decide what sort of relationship she'll have with her stepmother (Mare Winningham); and Cristina decides to fight for her relationship with Burke, despite her history with Colin Marlow (Roger Rees). Meanwhile, Alex grows more attached to Jane Doe (Elizabeth Reaser). Joan Waring: Dee Wallace.