Featured Research

from universities, journals, and other organizations

Decades on, bacterium's discovery feted as paragon of basic science

Date:

September 12, 2013

Source:

University of Wisconsin-Madison

Summary:

Over time, the esoteric and sometimes downright strange quests of science have proven easy targets for politicians and others looking for perceived examples of waste in government — and a cheap headline.

Share This

Lower geyser basin, Yellowstone national park. In 1966, microbiologist Tom Brock's National Science Foundation-supported treks to Yellowstone National Park to study life in the park's thermal springs might easily have been singled out as a feckless science project, deserving of a "Golden Fleece Award."

Over time, the esoteric and sometimes downright strange quests of science have proven easy targets for politicians and others looking for perceived examples of waste in government -- and a cheap headline.

Related Articles

In 1966, microbiologist Tom Brock's National Science Foundation-supported treks to Yellowstone National Park to study life in the park's thermal springs might easily have been singled out as yet another feckless science project, deserving of a "Golden Fleece Award."

But Brock, then a professor at Indiana University, and Hudson Freeze, an undergraduate student working with Brock at Mushroom Spring in the Lower Geyser Basin of Yellowstone, found something that by any measure validates investments in basic science, the undirected search for new knowledge.

At the time, Brock was simply interested in studying the microbial ecology of the thermal springs that make Yellowstone famous. It was a frontier of knowledge as scientific dogma held that life, or at least photosynthetic life, could not occur at temperatures above 160 degrees Fahrenheit.

But to their astonishment, Brock and Freeze found a bacterium, later dubbed Thermus aquaticus, that made its entire living in the scalding waters of Mushroom Spring. The discovery set the stage for the branch of science that studies life in extreme environments and, most tangibly, yielded an enzyme, Taq polymerase, that is central to the technology for amplifying DNA -- revolutionizing everything from medical diagnostics to criminal forensics.

"We were looking for a simple system where one could do basic research in microbial ecology. Everything fell out of that," recalls Brock, now an emeritus professor of bacteriology at the University of Wisconsin-Madison. "We didn't know there were these organisms that could live in boiling water."

Now, almost 40 years after discovering and describing the organism, Brock and Freeze are being recognized with the Golden Goose Award, an award aimed at celebrating "seemingly obscure studies that have led to major breakthroughs and resulted in significant societal impact."

Conferred by a gaggle of organizations -- the American Association for the Advancement of Science, the Association of American Universities, the Association of Public and Land-grant Universities, the Breakthrough Institute, the Progressive Policy Institute, the Science Coalition, the Task Force on American Innovation, and United for Medical Research -- the Golden Goose Award is given for federally-funded research that has led to "demonstrable, significant human and economic benefits."

The enzyme derived from the Thermus aquaticus bacterium powers polymerase chain reaction, or PCR. It is a technique used routinely to take trace amounts of DNA and amplify it for identification or study. The Taq polymerase is useful because it is stable at the high temperatures PCR requires to denature DNA and exponentially replicate target strands. The technology -- for which its inventor, Kary Mullis, was awarded the Nobel Prize -- is widely used in molecular biology, criminal forensics and medical diagnostics.

The Golden Goose Award was originally conceived by Congressman Jim Cooper of Tennessee to help educate members of Congress and the public about the value of basic scientific research. The name is a play on the Golden Fleece Awards, given by the late Wisconsin Sen. William Proxmire between 1975 and 1988, targeting specific federally funded research grants as examples of government waste.

"We've all read stories about the study with the wacky title, the research project from left field," Cooper says. "But off-the-wall science yields medical miracles. We can't abandon research funding only because we can't predict how the next miracle will happen."

Taq polymerase has gone on to be a workhorse molecule of science in good measure because Brock and Freeze deposited samples of the organism in the American Type Culture Collection, a repository where others can freely obtain cultures of the organism for little or no cost. It was there that Mullis and his collaborators found Thermus aquaticus and its enzyme when they were looking to replace an E. coli enzyme that did not survive the high temperatures of PCR.

Although Brock began his career at the Upjohn Co. looking for new antibiotics, after a few years he turned to the professor business and basic research: "Everything I ever did was basic," says Brock. "It's great that this discovery happened, but I wouldn't have predicted it."

Brock and Freeze will receive their award at a Capitol Hill ceremony on Sept. 19.

Mar. 31, 2015 — Using the assessment tool ForWarn, US Forest Service researchers can monitor the growth and development of vegetation that signals winter's end and the awakening of a new growing season. Now these ... full story

Mar. 31, 2015 — Until now electric fences and trenches have proved to be the most effective way of protecting farms and villages from night time raids by hungry elephants. But researchers think they may have come up ... full story

Mar. 31, 2015 — Researchers have detected a human fingerprint deep in the Borneo rainforest in Southeast Asia. Cold winds blowing from the north carry industrial pollutants from East Asia to the equator, with ... full story

Mar. 31, 2015 — A team of engineers and biologists reports new progress in using computer modeling and 3D shape analysis to understand how the unique grasping tails of seahorses evolved. These prehensile tails ... full story

Mar. 31, 2015 — As the five-year anniversary of the explosion of the Deepwater Horizon oil rig approaches, a new report looks at how twenty species of wildlife are faring in the aftermath of the ... full story

Mar. 31, 2015 — Scientists have uncovered the earliest fossilized evidence of an insect caring for its young. The findings push back the earliest direct evidence of insect brood care by more than 50 million years, ... full story

Mar. 31, 2015 — New research has scientists re-thinking how a lethal fungus grows and kills immune cells. The study hints at a new approach to therapy for Candida albicans, one of the most common causes of ... full story

Mar. 31, 2015 — The most virulent strains of Streptococcus suis, the leading cause of bacterial meningitis in adult humans in parts of southeast Asia and in pigs around the world, are likely to have evolved and ... full story

Mar. 31, 2015 — Darwin's evolutionary theory predicts survival of the fittest. So why do different survival tactics co-exist, if evolution should always favor the winning strategy? To answer that question scientists ... full story

Bionic Ants Could Be Tomorrow's Factory Workers

Reuters - Innovations Video Online (Mar. 30, 2015) — Industrious 3D printed bionic ants working together could toil in the factories of the future, says German technology company Festo. The robotic insects cooperate and coordinate their actions and movements to achieve a common aim. Amy Pollock reports.
Video provided by Reuters

Lions Make Surprise Comeback in Gabon

AFP (Mar. 30, 2015) — Lions have made a comeback in southeast Gabon, after disappearing for years, according to live footage from US wildlife organisation Panthera. Duration: 00:32
Video provided by AFP

May 22, 2013 — The discovery of potential environmental and human health effects from disposal of millions of rechargeable lithium-ion batteries each year has led scientists to recommend stronger government ... full story

July 10, 2012 — A new biofuel production process produces energy more than 20 times higher than existing methods. The results showcase a novel way to use microbes to produce biofuel and hydrogen, all while consuming ... full story

May 13, 2011 — Politicians should be careful when they rail against mainstream news media. A new study shows that perceived bias of media outlets can lead to increased political engagement -- but only on specific ... full story

Aug. 12, 2010 — According to 16 social science researchers from across the country, a renewed federal effort to fix the nation's stalled nuclear waste program is focusing so much on technological issues that it ... full story

ScienceDaily features breaking news and videos about the latest discoveries in health, technology, the environment, and more -- from major news services and leading universities, scientific journals, and research organizations.