Question about using MVPS Hosts for the first time.

I recently stumbled upon MVPS hosts and noticed that it's a nice alternative to the immunization of Spybot Search and Destroy's one (which I find out that it's not so up-to-date anymore to the better alternatives, like MVPS).

But my question is as follows: if I'm going to use MVPS do I need to do an undo first in Spybot S&D immunization before installing MVPS?

Like in this example picture below, so that's everything back to zero (on the 'protected' row)?: