Isothiocyanate

Posted December 19, 2018byundertow

The byproduct of a reaction between two compounds (glucosinolates and myrosinase) found in the leaves and stems of cruciferous vegetables. Isothiocyanates inhibit phase 1 biotransformation enzymes (enzymes that transform procarcinogens into carcinogens) and activate phase 2 detoxification enzymes (enzymes that protect cells and DNA from free radicals and carcinogens). Examples of phase II enzymes include UDP-glucuronosyltransferases, sulfotransferases, N-acetyltransferases, glutathione S-transferases, and methyltransferases.