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Following the murder of a physicist, Father Silvano Bentivoglio, a symbolist, Robert Langdon, and a scientist, Vittoria Vetra, are on an adventure involving a secret brotherhood, the Illuminati. Clues lead them all around the Vatican, including the four altars of science, Earth, Air, Fire and Water. An assassin, working for the Illuminati, has captured four cardinals, and murders each, painfully. Robert and Vittoria also are searching for a new very destructive weapon that could kill millions.

Despite his notorious relationship with the Roman Catholic church, Harvard symbologist Robert Langdon is once again called upon to decipher the clues to a catastrophic conspiracy. The Pope has died, and before a conclave can begin to determine his successor, the four preferitti (primary hopefuls for the papacy) are kidnapped. An ominous threat of their hourly demise, along with the complete annihilation of Vatican City, is issued as an elaborate revenge scheme by a persecuted group known as the Illuminati. With their meager time limit steadily counting down, Langdon, accompanied by beautiful physicist Vittoria Vetra, must travel throughout Rome to unravel the carefully hidden signs that will lead them to a terrifying adversary, a harrowing discovery, and the shocking truth.

The Pope has died and the conclave has been called. Four candidates have been chosen. However, before the voting, the four candidates are killed one by one. The killer leaves clues that seem to say that he or she is a member of the Illuminati. Strangely though, the Illuminati was long thought to be eradicated. Who is the mastermind? Who revived the Illuminati? What do they want?

After the death of the Pope, the conclave has gathered in a locked room to choose his successor among four cardinals designated "preferitti". However the quartet is abducted by the Illuminati, a secret brotherhood that was supposed eradicated. The symbologist Robert Langdon and the scientist Vittoria Vetra, who had her powerful and dangerous prototype of antimatter research stolen, are invited by the Vatican police to help them in their investigations. They are received by the receptive Camerlengo, Patrick McKenna, and by the reluctant Commander Richter. They are informed that the Illuminati have promised to kill each cardinal every hour from 8:00 PM and then blow up Vatican City with the antimatter. Robert and Vittoria have a few hours to unravel the clues and discover where the lethal weapon might be hidden.

Synopsis

Under the watchful eyes of Father Silvano Bentivoglio and Dr. Vittoria Vetra, the European Organization for Nuclear Research (CERN) initiates the Large Hadron Collider and captures three vials of antimatter...