Biomarkers & Translational Tools

Biomarkers and Translational Tools Community (BTT)

Community Goals

Scientific Expertise:

The Biomarkers and Translational Tools (BTT) Community facilitates interactions among experts across multidisciplinary fields to foster translational science with a focus on individuals via patient care and society via healthcare. The interactions are through social media, email blasts, and teleconferences with focused scientific content.

Catalyst for Innovation:

The BTT Community is a catalyst for innovation by sponsoring a range of scientific programs at the Annual Meeting focused on biomarker and translational tools.

Influence and Impact:

The BTT Community is the lead group engaged in promoting the use of biomarkers and other translational tools for optimizing drug development and patient care.

Education and Communication:

The BTT Community offers educational opportunities via the Annual Meeting and other fora

Organizational Effectiveness:

Leadership within BTT will be expanded by establishing a Network Steering Committee.

The BTT Community has regularly scheduled teleconferences and utilizes social media to engage members throughout the year.

The BTT Community fosters the career of its members by assisting in recognizing members for individual achievements and contributions to ASCPT, sponsoring educational programs, and providing opportunities for networking activities throughout an individual’s career.

ASCPT 2018 Annual Meeting

Biologics and Biomarkers & Translational Tools (BTT) Joint Community Meeting
FRIDAY, MARCH 23, 2018, 8:00 am-9:00 am
Room: Florida 1/2
This session will include a Community business discussion and programming ideas and feature two scientific presentations, "Intra Tumor Analysis of Trastuzumab Distribution by PID Staining, Breakthrough Method with High Visuality and Single Cell Quantification" and "Improved Prediction of Infliximab Clearance Using Erythrocite Sedimentation Rate and Anti-Infliximab Antibody Levels in Pediatric Patients with Inflammatory Bowel Disease."

Upcoming Webinars

Joint Systems Pharmacology and Biomarkers & Translational Tools Community Webinar
Title: Quantitative Systems Pharmacology (QSP) Modeling of Drug-Induced Nephrotoxicity – Bridging the Link Between Drug Exposure, Urinary Biomarkers and Renal DysfunctionDate and Time: Friday, February 16, 2018, 12:00 pm ETSpeakers: Yeshitila Gebremichael, PhD, Scientist, DILIsym Services., Inc. Moderators: Richard Graham, PhD, Senior Director, Theravance Biopharma and BTT Community ChairDescription: Drug-induced nephrotoxicity is a challenging problem in both drug development and clinical treatment of critically ill patients. Detecting the potential for nephrotoxicity early in the drug development process is vital for safe development and dosing of therapies. Many novel urinary biomarkers that are injury-specific and more sensitive than traditional biomarkers have been identified recently, whereas interpretation remains challenging. Furthermore, a quantitative framework that links biomarkers signals to underlying cellular injury and renal dysfunction is lacking. Such framework plays a crucial role in safe drug development and clinical treatment. By coupling observations from preclinical urinary biomarkers and histopathology data with cell biology, renal physiology, and the physiologic processes involved in biomarker expression, we developed a multiscale quantitative systems pharmacology (QSP) model of drug-induced acute kidney injury.Registration Link: https://attendee.gotowebinar.com/register/2375674479891555073