Acute myocardial infarcts (AMI) are typically discriminated with T2-STIR imaging [1], albeit with limited specificity [2]. Guided by the association that T2-STIR images identify AMI territories on the basis of edema-related T2 changes, even some of the recently proposed improvements [2, 3] have relied on preferential sensitization of magnetization to T2-weighting. However, whether T2-STIR imaging itself may also be sensitive to other sources of contrast have not been fully investigated.

Affected territories were identifiable on STIR (at both TEs) and LGE images, and on T2- and T1-maps as hyperintense zones (Figure 1). Table 1 lists the source of contrast in STIR images obtained at the different TEs. STIR signal changes at TE = 7.1 ms were primarily attributable to PD. However, at TE = 64 ms, the contrast was largely based on T2 changes, along with significant contribution from PD. Mean signal intensity changes between affected and healthy territories from STIR images over all studies were: 33.4 ± 7.1% (TE = 7.1 ms) and 65.7 ± 12.9% (TE = 64 ms).

Table 1

Mean T1, T2 and PDF contributions to image contrast between affected and healthy myocardial territories assess during each study.

Source

STIR (TE = 7.1 ms)

STIR (TE = 64 ms)

T1 effects

-25.3.7 ± 12.7%

-13.0 ± 6.7%

T2 effects

15.1 ± 3.7%

86.2 ± 25.7%

PD effects

115.9 ± 15.6%

25.5 ± 17.3%

Figure 1

Representative short-axis images obtained from a dog subject to ischemia-reperfusion injury in the LAD territory. A STIR (TE = 7.1 ms); B: T2-STIR (TE = 64 ms); C: T1 map; D: T2 map; E: PSIR LGE magnitude image; F: PSIR LGE phase image. A and B were obtained with body coil, while C-F were ontained with surfance coil. Note that the LAD territory is hyperintense in A and B, indicating that even in the presence of a low T2-weighting (A), the affected region can be readily discriminated. Corresponding myocardial territories that appear hyperintese in A and B, also show elevations in T1 and T2 values (C and D, respectively). E and F confirm the presence of LAD infact.

In addition to the T2 changes, edematous territories identified on the basis of long TE STIR (T2-STIR) images, have substantial contribution from PD. Our findings suggest that methods that rely on the identification of edematous territories solely on the basis of T2 changes may compromise sensitivity. Approaches that combine PD and T2 contrast in a synergistic manner are expected to be the most sensitive for detecting myocardial edema.

At the low TE (7.1 ms), PD effect dominates, while at the higher TE, T2 contributions are dominant with a reduced, but a significant, contribution from proton density. Note that the T1-effects are always in the opposite direction to PD and T2 effects, as expected.