RNA Processing & Modification Antibodies

RNA processing and modifications to RNA are crucial to numerous cell functions and give insight into a multitude of biological processes that are influenced by RNA activities, such as RNA interference. RNA interference (RNAi) is a gene-regulating process in which genes are silenced by RNA molecules such as shRNA, siRNA, and miRNA, usually destroying mRNA molecules and lowering protein expression. RNAi and gene silencing antibodies target the proteins involved in the various steps of gene silencing as part of the RNA interface. Once RNA is transcribed from DNA, it can undergo a number of processing events, including splicing, capping and additional modifications before it carries out its final function in the cell. Various RNA modifications such as N6-methyladenosine (m6A), the most abundant mRNA modification, are of interest to researchers investigating the epigenetic modifications’ consequences and especially how they contribute to the development of diseases such as cancer.