After 10 years in the research and federal drug approval pipeline, Wixom-based Rockwell Medical Inc. has received the green light to market its Triferic drug, a medication for kidney disease patients who need iron replacement therapy.

Federally qualified health centers in Michigan are concerned about a potential setback on Sept. 30, as $11 billion in financial support to them that was part of a trust fund set up under Obamacare is scheduled to run out.

Eric Williams wears many hats at Wayne State Law School, and now he's added a new one, forming Wayne Alumni Law Group, a new law firm dedicated to assisting Detroit startups. In turn, it gives fresh law grads a chance to gain valuable experience helping these new companies while working with more seasoned law professionals.

U.S. State Department's Charles Rivkin, the assistant secretary of state for economic and business affairs, arrived in Detroit on Wednesday to pitch the White House's key trade initiatives in conjunction with the trip.

Southfield-based Chemico Group of Cos. acquired the shares previously held by Indianapolis-based Mays Chemical Co. of joint venture ChemicoMays LLC, the companies announced. Terms of the deal were not disclosed.

Think your job is a bear? Try selling tickets on a Great Lakes cruise ship in March. That's the task awaiting the recipient of the short straw at Great Lakes Cruise Co., whose land-based headquarters is in Ann Arbor. Other statewide news: Social Kitchen to open in Grand Rapids Downtown Market; Holland table maker's expansion promises to create 200-plus jobs

Over the past several years, Michigan has increased Medicaid waivers for home- and community-based care, enabling low-income seniors to receive health care at home instead of having to move to a nursing facility.

This year, when it came to top honors for those who made headlines, it was important to recognize Kevyn Orr and now-retired U.S. Bankruptcy Judge Steven Rhodes, both of whom were part of the team responsible for managing the Detroit bankruptcy.

Northland Center's closure, approved by an Oakland County judge last week, has been a long time coming. But 50 years ago, with a Hudson's store as an anchor for 110 other retailers, Northland was a global wonder.

This year, when it came to top honors for those who made headlines, it was important to recognize Kevyn Orr and now-retired U.S. Bankruptcy Judge Steven Rhodes, both of whom were part of the team responsible for managing the Detroit bankruptcy.

Owner and chef Nikita Sanches will compete on Tuesday's episode of CNBC's "Restaurant Startup" for the opportunity to open a pop-up restaurant in Los Angeles and, ultimately, win the financial backing of wealthy investors.

This list of Southeast Michigan employers encompasses companies with headquarters in Livingston, Oakland, Wayne, Washtenaw or Macomb counties. Number of full-time employees may include full-time equivalents. It is not a complete listing but the most comprehensive available.