Interpretive Summary: Haemophilus parasuis is a significant infectious disease problem in swine. This pathogen causes pneumonia as well as Glässer’s disease, a syndrome that includes polyserositis, arthritis and meningitis. We report here the nearly complete genome sequences of ten H. parasuis isolates from around the world that collectively represent the full spectum of virulence, from avirulent to highly invasive. Examination of this genomic information will greatly facilitate our understanding of the genetic basis for virulence and guide the identification of novel protective immunogens and bacterial products useful for diagnosis of infection.

Technical Abstract:
Haemophilus parasuis is a swine pathogen that causes pneumonia and Glässer’s disease, a systemic syndrome of polyserositis, arthritis, and meningitis. We report here the draft genomes of ten geographically diverse isolates collectively representing the full virulence spectrum of H. parasuis. These data will greatly enable the study of virulence mechanisms.