Synopsis:This project aims to elucidate the molecular mechanisms responsible for an inherited form of mental retardation known as Fragile X syndrome, for which there is currently no cure. It is proposed that the regulation of the cytoskeleton of the neuron may be altered in these individuals, thus interfering with synaptic plasticity processes and causing disturbances in the cognitive function. For this project a multidisciplinary approach is being used that includes molecular biology, electrophysiology, fluorescence microscopy and analysis of behaviour in mouse models. It is believed that this research project will contribute to the elucidation of the physiological processes that control cognitive function, and in particular to the understanding of the pathological changes that result in the mental retardation associated with Fragile X syndrome.

SCIENTIFIC PRODUCTION

1 paper at international conferences
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RESEARCH EXPERIENCE
Dr. Esteban's research team has extensive experience in molecular and cellular studies of the synaptic function. In particular, it has been a pioneer in the characterisation of the intracellular machinery regulating neurotransmitter receptor transport in synapses. The importance of this work to human health problems is evidenced by the funding obtained in the last five years from many international agencies related to biomedicine, such as the National Institutes of Health (NIH), Alzheimer's Association, National Alliance for Research on Schizophrenia and Depression (NARSAD) and the Dana Foundation.