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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

SP and CGRP levels increased in mucosal tissue and in supernatant in response to HCl (Fig. 2 and 3) and the increases were abolished by the TRPV1 receptor antagonist 5'-iodoresinferratoxin (IRTX) or by neural block with tetrodotoxin, suggesting that TRPV1-induced production of SP and CGRP was neurally mediated.