A quarter of the world population still smokes and at least one out of every two smokers will die due to smoking. Primary care physicians are the most important care providers for smoking cessation treatment in many countries in the world. Yet, there many reasons why primary care physicians are hesitant or even reluctant to deliver this care, such as time constraints or a perception of lack of competence. This position statement gives practical guidance to the primary care physician to overcome these constraints. A very brief advice hardly costs any time and saves many lives worldwide when given by a primary care provider.