“To regulate Commerce with foreign Nations, and among the several States, and with the Indian Tribes”

Congress was never delegated “police powers” to prohibit a use that causes substantuial injury to general public health and safety; as well as to “permit” that use with conditions to avoid, minimize and mitigate damage. The “police powers” of regulation belong to the state and local governments.

“Regulate” in the Commerce Clause means “to make regular.” This is to ensure that a metric system is a common unit of measurement among the states (mph, gallon, acre,); that interstate banking rules are uniform; that rules of navigation among the states are in common.

It is to ratify treaties with foreign nations to extend mutual rights of persons and property and protection of same. It is to ensure that settlers don’t make private treaties with Indian nations to settle territory beyond boundaries, such as the Stanwix Line, causing bloody Indian Wars.

It was never intended to create a regulatory power that reaches into any and every activity in the stream of Commerce. It was never intended to allow regulation of endangered foxes because tourists might cross the state line to see them.