POTENTIAL FOR ENVIRONMENTAL AND THERAPEUTIC AGENTS TO INDUCEIMMUNOTOXICITY
NIH GUIDE, Volume 23, Number 40, November 18, 1994
RFP AVAILABLE: NIH-ES-95-22
P.T. 34
Keywords:
Toxicology
Immunology
Environmental Effects
National Institute of Environmental Health Sciences
The National Institute of Environmental Health Sciences (NIEHS),
National Institutes of Health (NIH), is soliciting proposals from
offerors that have the capabilities and facilities to perform the
following tasks: Task I, demonstrate proficiency in the performance
of the Immune Testing Assays provided by the Environmental Immunology
and Neurobiology Section (EINS) to detect chemical-induced immune
alteration. The sub-task I-A Immunosuppression will involve
Immunopathology, Humoral Mediated Immunity, Cell Mediated Immunity,
Cell Quantification, Non-specific Immunity and Host Resistance Assays
and sub-task I-B Hypersensitivity Assays will involve Mouse ear
swelling test (MEST) and Local lymph node assay (LLNA). Task II-A,
upon demonstration of proficiency, the contractor will test four
xenobiotics per year using tests described in Task I-A. Task II-B,
the contractor will test two xenobiotics per year thereafter. Task
II-C the contractor will test two xenobiotics per year for their
potential to produce skin hypersensitivity in the mouse. Task II-D,
the contractor will test one xenobiotic per year for the potential to
influence autoimmune disease. Task III - Development and/or
Evaluation of New and Improved Technology will be conducted beginning
in year two of the contract, e.g., to quantitate certain biomedical
changes. The Government estimates that the project will require
approximately 1.5 professional person-years, 1.8 senior technical
person years and 1.0 technical person years per contract year. The
estimated period of performance is five years.
INQUIRIES
All responsible sources may submit a proposal that will be considered
by the Agency. Release of Request for Proposals (RFP) No. NIH-
ES-95-22 is anticipated on or about November 9, 1994 with proposals
due January 3, 1995. Requests must reference the RFP number and must
be directed to:
Howard Hill
Contracts and Procurement Management Branch
National Institute of Environmental Health Sciences
79 T.W. Alexander Drive, Building 4401 Research Commons
P.O. Box 12874
Research Triangle Park, NC 27709
Telephone: (919) 541-4971
FAX: (919) 541-2712
.