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Chapter Six: What Makes a Prion: Infectious Proteins From Animals to Yeast

Abstract

1 Introduction

2 Pathogens and the Emergence of the Prion Hypothesis

3 Evidence Found: Identification of Animal, Yeast, and Other Prions

4 What Makes a Prion: Features That Define Prions

5 The Enlarging Prion Concept in Disease and Beyond

6 Concluding Remarks

Chapter Seven: The Structure of Mammalian Prions and Their Aggregates

Abstract

1 Introduction

2 Amorphous Aggregates and Oligomers

3 Two-Dimensional Crystals

4 Amyloid Fibrils

5 Outlook on the Future Structural Biology of Prions

6 Concluding Remarks

Acknowledgments

Index

Description

Early Stage Protein Misfolding and Amyloid Aggregation, Volume 329, the latest in the International Review of Cell and Molecular Biology series presents comprehensive reviews and current advances in cell and molecular biology, including articles that address the structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth.

The series has a worldwide readership and maintains a high standard by publishing invited articles on important and timely topics as authored by prominent cell and molecular biologists.

Key Features

Provides comprehensive reviews and current advances

Presents a wide range of perspectives on specific subjects

Includes valuable reference material for advanced undergraduates, graduate students, and professional scientists

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About the Serial Volume Editor

Massimo Sandal

MMassimo Sandal received his doctorate qualification from the University of Bologna in 2008 for his research on active conformers of proteins. He has gone on to conduct research on proteins in departements of Biochemistry and Biotechnology across Europe. Following on from the University of Bologna, he was a post-doctoral FEBS Fellow at the University of Cambridge and a post-doctoral associate at the University of Verona in 2012. From 2013 to 2016 he was associated to the German Research School for Simulation Sciences in Jülich, Germany.

Affiliations and Expertise

German Research School for Simulation Sciences, Aachen, Germany

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