My experience with the 300Wby is that its expensive even if you reload, heavish on recoil and muzzle blast and generally not needed unless you just want one. You can't go wrong with either the .270 or 30'06 anywhere in the country. I'd favor the 30'06 because of the broad options available in ammo selection, plus I'm a .284/7mm junkie and have no need for the .270.