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Authors' reply

Office of Public Policy and Ethics, Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland 4072, Australia

School of Public Health and Community Medicine, University of New South Wales, Sydney Hospital, PO Box 1614, Sydney, New South Wales 2001, Australia

School of Psychiatry, University of New South Wales, Randwick, New South Wales 2031, Australia

EDITOR—Our critical finding was the relation between decline in suicide rate and exposure to antidepressants across age groups in both sexes. We agree that time series data must be interpreted cautiously; that is why we considered alternative explanations.

We disagree with Moncrieff that we should have used ratios of daily dependent doses. This would have been an alternative measure of change in exposure but not of overall antidepressant exposure. We agree that the daily dependent doses will underestimate prescribing levels of tricyclic …