Mutation details: A targeting vector was designed to insert a T1799A mutation into exon 15 and a loxP-stop-loxP cassette containing a minigene encoding exons 15-18 of wild-type Braf with a splice acceptor sequence at the 5' end into intron 14. Upon cre expression, the loxP-stop-loxP is deleted, enabling expression of the knock-in sequence. This mutation increases the kinase activity of the protein.
(J:104375)

Phenotypes

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Disease models

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