Amphlett, known as much for her distinctive voice as for her sexy schoolgirl stage outfits, had been bravely battling both breast cancer and multiple sclerosis. She reportedly died at home in her sleep surrounded by loved ones.

The Australian-born singer announced in 2007 that she was suffering from MS and in 2010 confessed she’d been diagnosed with breast cancer.

“Christine Joy Amphlett succumbed to the effects of breast cancer and multiple sclerosis, diseases she vigorously fought with exceptional bravery and dignity,” Amphlett’s husband Charley Drayton said in a statement (via Fox News).

He added, “Chrissy’s light burns so very brightly. Hers was a life of passion and creativity. She always lived it to the fullest. With her force of character and vocal strength, she paved the way for strong, sexy, outspoken women.”

Our thoughts go out to Amphlett’s family, friends and fans — including actor Russell Crowe, who played her son in the Australian stage production of ‘Blood Brothers’ and tweeted his own mournful message for the songstress.

Dear Chrissie, The last time I saw you was in the Botanic Gardens, loving life and reciting verse. That’s how I’ll remember you, your boy, R

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