Structure of an unliganded simian immunodeficiency virus gp120 core.

This article reports an unliganded simian immunodeficiency virus (SIV) gp120 structure that reveals, by comparing to the previously known liganded homologous HIV gp120 structure, a dramatic refolding of the molecule upon binding to cellular receptors.

The structure unravels the distinct antigenic surface of this unliganded gp120 and a binding pocket for recently discovered viral-entry inhibitors.

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