Filmed entirely on location and directed by series creator and executive producer Matthew Carnahan, the final episode, named "No Es Fácil," marks the first time an American scripted series was shot on the island since the restoration of diplomatic relations.

"House of Lies is a comedy that has frequently been ahead of the curve," Showtime Networks President and Chief Executive Officer Nevins said in a statement. "Over the course of its five seasons, it has tackled such hot-button topics as gender identity, wealth inequality, white privilege, police brutality, interracial relationships, and code-switching with honesty and a biting sense of humor. Matthew Carnahan and Don Cheadle have been dream partners and impeccable leaders. The core cast of Don, Kristen, Ben and Josh are one of the best comedy teams on television. They have brought the series to an incredibly satisfying conclusion with this historic final episode shot in Cuba."

"Creating and running House of Lies has been a true dream gig, a creative apotheosis," added Carnahan. "Working with the remarkable team that Jessika Borsiczcky, David Walpert and I were allowed to put together, along with the incredible cast and crew, coming to work every day was a joy. Getting to work with heroes like Don Cheadle, Kristen Bell and Glynn Turman, breaking out amazing performers like Dawn Olivieri and the shockingly funny Josh Lawson; seeing Ben Schwartz, already so well-known as a comedic actor doing a deep-dive into really complex work; watching great actors like Matt Damon be willing to skewer versions of themselves; and then going out on the high note that is shooting in Cuba -- these are all the kinds of reasons I got into this business in the first place."