Growth Hormone Overrated in Athletic Gains: Study

NEW YORK (AP) - Athletes who take human growth hormone may not
be getting the boost they expected.

While growth hormone adds some muscle, it doesn't appear to
improve strength or exercise capacity, according to a review of
studies that tested the hormone in mostly athletic young men.

"It doesn't look like it helps and there's a hint of evidence
it may worsen athletic performance," said Dr. Hau Liu, of Santa
Clara Valley Medical Center in San Jose, Calif., who was lead
author of the review.

Growth hormone, or HGH, is among the performance enhancers
baseball stars Roger Clemens and Andy Pettitte were accused of
taking in the blockbuster Mitchell Report. Clemens denies using the
hormone, while Pettitte admits using it.

But the new research has some limitations and sheds no light on
long-term use of HGH. The scientists note their analysis included
few studies that measured performance. The tests also probably
don't reflect the dose and frequency practiced by athletes
illegally using the hormone. Experiments like that aren't likely to
be conducted.

"It's dangerous, unethical and it's never going to be done,"
said Dr. Gary I. Wadler, a member of the World Anti-Doping Agency
and a spokesman for the American College of Sports Medicine.

Consequently, those in the field have to depend on such reviews
or "what we hear on the ground," he added.

Human growth hormone is made by the pituitary gland and promotes
growth. A synthetic version has been available since the 1980s and
its use is restricted for certain conditions in children and
adults, including short stature, growth hormone deficiency and
wasting from AIDS.

Although banned for other uses, growth hormone has been used by
a variety of athletes and was cited along with steroids as one of
the performance-enhancing drugs abused by baseball players in the
report in December by former Senate majority leader George
Mitchell. Several athletes, including Pettitte, have said they used
HGH while recovering from an injury, an issue not covered in the
review.

"There are a lot of claims that it's this wonder drug," said
Liu.

Wadler said one of the appeals of growth hormone for athletes is
that it can't be detected in a urine test. A blood test will be
available soon, and another is in development, he said.

"They think they are getting a free ride - they aren't getting
a drug test," he said. "They believe they are stronger and
bigger."

Liu and his colleagues at Stanford University sought to find out
if growth hormone really could improve performance. They looked for
the best published tests, those comparing participants who got the
hormone to those who didn't get the treatment.

They analyzed 27 studies involving 440 participants. The results
were released Monday by the Annals of Internal Medicine.

Researchers found that those who got the hormone put on about 5
pounds more of muscle, and lost about 2 pounds more of fat,
although the fat loss wasn't statistically different. The
researchers said some of the extra body mass could just be fluid
buildup.

There was no difference found in strength or exercise stamina
between the two groups, but there were only two strength studies
and eight that measured exercise. Those who got the hormone had
more side effects including swelling and fatigue.

The review couldn't consider long-term effects, since the
longest study was three months, and most were much shorter.

The researchers also said the doses used in the research may be
lower than those used by athletes, who may be combining growth
hormone with other performance-enhancing drugs.

Dr. Alan Rogol of the University of Virginia and the Indiana
University School of Medicine, said the work was a good review but
had to rely on inadequate research.

"There are just tons of things we don't know," said Rogol.

The California researchers had support from Stanford, government
agencies and Genentech Inc., which makes growth hormone; none of
the groups had a role in the study. Two researchers also have been
consultants or received grants from Genentech and other drugmakers.