The Cytoskeleton

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The cytoskeleton is one of a few biological areas with broad potential for drug discovery and development and has been scientifically and commercially validated in a wide variety of human diseases.

In heart failure the cytoskeleton plays a fundamental role in cardiac muscle contraction and has been linked to the origins of heart failure, a disease of impaired cardiac function. Certain commonly used heart failure drugs that work by indirectly modulating cytoskeletal function have limited therapeutic value due to their clinical side effects.

Our understanding of the cytoskeleton allows us to develop potentially safer and more effective drugs for heart failure and other diseases.