About the Journal

This journal covers the formation, growth and differentiation of the human embryo. It is intended to bring to public attention new research on biological and clinical research on human reproduction and the human embryo including relevant studies on animals. It is published by a group of scientists and clinicians working in these fields of study, in partnership with Elsevier. Its audience comprises researchers, clinicians, practitioners, academics and patients.

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The Chief Editor and Editors of RBMO are pleased to announce the results of this year's

A report of a Summit convened to critically review the literature on progesterone supplementation in assisted reproductive transfer cycles in general, and after frozen-thawed embryo transfer, and to provide guidance on the most clinically relevant issues.FREE ACCESS // CME activity

x: Is formulated and lyophilized, recombinant human Müllerian inhibiting substance, also known as anti-Müllerian hormone (AMH), suitable for the preparation of a WHO international standard to calibrate AMH immunoassays?

Patentability of time-lapse monitoring has nothing to do with human dignity: A response to Alain Pottage

xIn December 2017, Alain Pottage published an article denying the patentability of a technique called Time-Lapse Monitoring (TLM). His argument was that this procedure, like all other embryo selection procedures, fails to respect human dignity. Here, we argue that this statement is mistaken because assisted reproductive technologies (ART) require a scarce resource, namely a woman’s uterus in the right physiological condition. Therefore, embryo selection using TLM is entirely appropriate, as it is not possible to guarantee that all of them will have access to the environment they need to develop.

Is blastomere multinucleation a safeguard against embryo aneuploidy? Back to the future

xI read with great interest the study by Seikkula et al. (2018) showing that transfer of binucleated and multinucleated frozen-thawed human embryos, though resulting in lower pregnancy and implantation rates as compared with the transfer of single-nucleated embryos, does not increase the occurrence of congenital anomalies and chromosomal defects among newborns. These findings are in agreement with those of previous studies showing that, in spite of increased prevalence of chromosomal errors at early cleavage stages in multinucleated embryos (Kligman et al., 1996; Staessen and Van Steirteghem, 1998; Ambroggio et al., 2011), blastocysts developing from such embryos have similar aneuploidy rates as those resulting from non-multinucleated embryos, suggesting the action of a self-correction mechanism during early cleavage divisions (Balakier et al., 2016).

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