As the incidence of renal cell carcinoma (RCC) and earlier incidental detection of small kidney masses has steadily risen over the past twenty years, minimally-invasive management of these lesions has become more common. (sages.org)

In this study, morcellated renal specimens resulting from laparoscopic nephrectomy/nephroureterectomy were evaluated retrospectively, and sampling strategy models were generated based on a statistical model that described the relationship of the fraction of specimen submitted, the tumor-to-kidney volume ratio (TKR), and the probability of identifying tumor within the sampled fraction of specimen. (cap.org)

Taking a page from breast cancer surgeons, urologist David C. Miller, M.D., of the University of Michigan and colleagues here reported that a kidney lumpectomy is an effective option for small renal masses, though it is not as commonly performed. (medpagetoday.com)

Partial nephrectomy, said Dr. Miller and colleagues, is associated with "potentially more favorable renal function and health-related quality of life among [partial nephrectomy] survivors, and our findings suggest a quality of care concern based on the possible under-use of a health service associated with favorable outcomes. (medpagetoday.com)

Percutaneous ablation also resulted in fewer complications than partial nephrectomy, though a conclusive comparison of survival outcomes was difficult since patients receiving the latter surgery were typically significantly younger and healthier on average. (ascopost.com)

As PCa death is not due to the primary tumor, but rather the formation of distinct metastasis, the ability to effectively model this progression pre-clinically is of high value. (jove.com)

At experiment termination, several distinct endpoints can be measured, such as size and molecular characterization of the primary tumor, the presence and quantification of circulating tumor cells in the blood and bone marrow, and formation of metastasis to the lung. (jove.com)

To improve post-injury survival and obtain more consistent and predictable results, we have developed two models of unilateral ischemia-reperfusion injury followed by contralateral nephrectomy. (jove.com)

The authors also compared radiologic and pathologic tumor staging for renal cell carcinoma removed by traditional nephrectomy and determined that although radiologic staging for RCC was good, overstaging and understaging can occur in five to 35 percent of cases. (cap.org)

However, conservative management with kidney-sparing endoscopic surgery is currently performed not only in those patients with imperative indications but also in those patients with low risk disease and normal, functioning contralateral kidneys, due to its similar oncological efficacy. (springer.com)

While the 4T1 breast tumor surgery model allows for the simulation of the effects of abdominal surgical stress on tumor metastases, its applicability to other tumor types needs to be tested. (jove.com)

An analysis of Surveillance, Epidemiology and End Results (SEER) registry data that Dr. Miller and colleagues reported today in the March issue of the Journal of Urology found that all-cause mortality was similar for partial nephrectomy and total nephrectomy, yet only 42% of patients with masses smaller than 2 cm received this kidney-sparing surgery. (medpagetoday.com)

The authors cautioned, however, that because their analysis does not include data from patients treated after 2001, the trend toward increased use of partial nephrectomy may make their "concerns unsubstantiated. (medpagetoday.com)

The investigators found that percutaneous ablation is associated with fewer complications and lower rates of kidney failure for older patients compared with radical nephrectomy-the procedure that is typically performed in that patient population. (ascopost.com)

Kidney tumors are often detected incidentally when doctors obtain imaging studies on patients for other medical reasons. (ascopost.com)

Older patients, who are already at increased risk for chronic renal failure, shouldn't always have to get their kidney taken out for a golf-ball or smaller sized tumor," Dr. Talenfeld said. (ascopost.com)

This study suggests that for many older patients requiring surgical treatment, percutaneous ablation should be the next choice after partial nephrectomy. (ascopost.com)

In hospitalized patients, over 50% of cases of acute kidney injury (AKI) are caused by renal ischemia 1-3 . (jove.com)

Using a protocol for prospective tissue banking and another protocol for retrospective banking, tumor and normal tissue samples from patients consented to these protocols were collected. (jove.com)

The procedure, called percutaneous ablation, involves the insertion of a needle through the skin into a kidney tumor, followed by the heating or freezing by the needle to destroy the tumor. (ascopost.com)

Percutaneous thermal ablation is an emerging treatment option for many tumors of the abdomen not amenable to conventional treatments. (jove.com)

During a thermal ablation procedure, a thin applicator is guided into the target tumor under imaging guidance. (jove.com)

Thermal tumor ablation can be performed at open surgery, laparoscopy or using a percutaneous approach. (jove.com)

The investigators, Ross J. Mason, a medical student, and Ricardo A. Rendon, MD, Associate Professor of Urology, defined a central mass as one extending into the kidney in direct contact with or invading the collecting system and/or renal sinus. (renalandurologynews.com)

Of note, Dr. Kenney co-authored the chapter on open kidney surgery for Campbell-Walsh Urology, the definitive and most widely read textbook in the field. (yale.edu)

Hi after 3 years of planning to do pd i have just had my tube fitted and had started training on the machine when i saw the surgeon about the planned removal of one or both of my huge pkd kidneys to enable me to go on the transplant list. (kidneypatientguide.org.uk)

the removal of the kidney to enable a transplant has always been known so i cant understand why they gave me a false impression of the future and let me go through the op to insert the tube with all its consequential pain, discomfort, loss of work and not least cost to the nhs only for it to have to be removed again and a fistula fitted. (kidneypatientguide.org.uk)

Ischemia-reperfusion induced acute kidney injury (IR-AKI) is widely used as a model of AKI in mice, but results are often quite variable with high, often unreported mortality rates that may confound analyses. (jove.com)

In recent years there has been substantial progress in the understanding of the mechanics of tumor invasion, and direct intracerebral inoculation of tumor provides the opportunity of observing the invasive process in a physiologically appropriate environment 2 . (jove.com)