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1 JNC VII criteria and non pharmacological measures Original Research Article ISSN: (P) Do joint national committee VII criteria also need to take non pharmacological measures into consideration? - Empirical evidence from slum resettlement colony from Delhi Sanjeet Panesar 1, Sanjay Chaturvedi 2, NK Saini 3, R. Avasthi 4, Abhishek Singh 5*,Pankaj Chikkara 6 1 Senior Resident, Department of Community Medicine, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India 2 Professor, Department of Community Medicine, UCMS, Delhi, India 3 Assistant Professor, Department of Community Medicine, UCMS, Delhi, India 4 Professor, Department of Medicine, UCMS, Delhi, India 5 Assistant Professor, Department of Community Medicine, SHKM Govt. Medical College, Haryana, India 6 Assistant Professor, Department of Forensic Medicine, PGIMS, Rohtak, Haryana, India *Corresponding author How to cite this article: Sanjeet Panesar, Sanjay Chaturvedi, NK Saini, R. Avasthi, Abhishek Singh, Pankaj Chikkara. Do joint national committee VII criteria also need to take non pharmacological measures into consideration? - Empirical evidence from slum resettlement colony from Delhi. IAIM, 2015; 2(1): Available online at Received on: Accepted on: Abstract Background: Currently Joint National Committee (JNC) VII criteria are used worldwide to diagnose hypertension but it does not take non pharmacological measures into consideration. Also, it does not consider Indian system of medicine. Objectives: To assess whether JNC VII in its present form is valid to diagnose hypertension correctly or revision is required especially for Indian communities where such practices are prevalent. Material and methods: The present community based cross-sectional sectional study was carried out in Nand Nagri, a slum resettlement of East Delhi which comes under field practice area of the Department of Page 15

2 Community Medicine, UCMS, Delhi from August 2010 to February Total 310 subjects aged years were selected through multistage systematic random sample. Though the blood pressure cut-offs considered in our criteria was similar to the JNC VII cut-offs (SBP 140 mmhg and or DBP 90 mmhg), the difference was in the last part of JNC VII definition of hypertension i.e. treatment by anti hypertensive medicines; our criteria comprised of this statement as any anti hypertensive measure. Chi-square (χ²) test was applied for analysis. Results: Overall 54 were found to have hypertension by JNC VII criteria whereas 61 by our criteria. Seven patients who were not hypertensive by JNC VII but hypertensive by our criteria and the difference was found to be statistically highly significant (p<0.001). Exercise was the most common non pharmacological measure adopted by male gender where as in females, salt restriction was the most common measure adopted. Conclusion: Our study emphasized inclusion of non-drug therapy measures into consideration while making diagnosis of hypertension in our setup. Key words Treatment, Control, Non pharmacological interventions, Hypertension. Introduction Non-communicable diseases especially cardiovascular diseases (CVD) are major causes of death and disability in low and middle income countries [1]. Over 80% of CVD deaths occur in such countries as their populations are more exposed to risk factors, and have less access to preventive efforts [2]. By 2020, it is expected that India will have more than 50% of the CVD cases in the world. World Health Organization (WHO) has named hypertension n as Silent Killer and it has been reported as seventh contributor to premature death in developing countries [3]. Hypertension is most commonly associated with cardiovascular diseases worldwide and is the most important modifiable risk factor for cardiovascular mortality. According to WHO, each year at least 7.1 million people die as a result of hypertension [3]. Despite the high prevalence; prevention, detection, treatment, and control of hypertension is suboptimal and unsatisfactory in developing countries like India [4]. It is established fact that non pharmacological measures also have significant role in treatment and control of hypertension. Currently JNC VII criteria are used worldwide to diagnose hypertension but it does not take non pharmacological cal measures into consideration. Also, it does not consider Indian system of medicine. Therefore it becomes essential to assess whether JNC VII in its present form is valid to diagnose hypertension correctly or revision is required especially for Indian communities where such practices are prevalent. Material and methods The present community based cross-sectional study was carried out in Nand Nagri, a slum resettlement of East Delhi which comes under field practice area of the Department of Community Medicine, University College of Medical Sciences (UCMS), Delhi from August 2010 to February It has a population of over 50,000 and mostly falling in the category of low socio-economic status. Page 16

3 The sample size was calculated with anticipated weight reduction, exercise, salt restriction, prevalence of hypertension as 27.5% [5], 5% smoking cessation, reduction in alcohol intake, Absolute precision, 95% Confidence Interval and stress management, yoga, meditation, etc. 10% non response error, as 310 adults over the age of 20 years. The study subjects were In depth enquiry was made regarding afore selected through multistage systematic random mentioned non-pharmacological anti sampling technique. One sub block was hypertensive measures taken by them. Relevant randomly selected from each of the five blocks socio-demographic data of the individuals was of the study area. Sampling unit was a also recorded. Ethical committee approved the household; a household was randomly selected study. Informed consent was obtained from the from first 20 households (sampling interval for study participants. 5%). Thereafter, starting from that household, every 20 th household was selected. All the The collected data was coded and entered in years subjects, residing in the selected Statistical Package for Social Sciences (SPSS), household for 6 months or more, were included version 20. The results were expressed as in the study. If there were no eligible subject in proportions. Chi-square (χ²) test was applied to the selected household or the house was closed test the difference across the groups and p<0.05 for 3 consecutive visits, it was replaced by a was considered statistically significant. contiguous us household without disturbing the allocation of next 20 th sampling unit. Results Blood pressure of all the subjects was measured according to JNC VII / American Heart Association (AHA) recommendations. JNC guidelines [6, 7] were followed for defining awareness, treatment and control of hypertension. Among the hypertensive s, subjects with prior diagnosis of hypertension/ high BP were considered as aware ; those with current anti hypertensive drug therapy as treated ; and subjects showing SBP <140 mmhg, DBP <90 mmhg, and taking anti hypertensive medication as controlled. Though the blood pressure cut-offs considered in our criteria was similar to the JNC VII cut-offs (SBP 140 mmhg and or DBP 90 mmhg), the difference was in the last part of JNC VII definition of hypertension i.e. treatment by anti hypertensive medicines; our criteria comprised of this statement as any anti hypertensive measure ; these measures taken include anti hypertensive drugs (which could be allopathic, ayurvedic, homeopathic, unani, siddha, dha, herbal medicine, indigenous medicines), non pharmacologic measures like The comparison made between JNC VII and our criteria to diagnose the hypertension among 310 subjects as per Table Overall 54 were found to have hypertension by JNC VII criteria whereas 61 by our criteria. Seven patients who were not hypertensive by JNC VII but hypertensive by our criteria and the difference were found to be statistically highly significant. (p<0.001) Proportion of aware subjects who controlled their blood pressure by adopting one or more non pharmacologic measure or life style was calculated. According to it, 8 subjects adopted non pharmacologic medication to control their BP of which 7 subjects were able to achieve BP control. All the 8 subjects who used non pharmacologic measures s were having Grade 1 hypertension as per Table - 2. The most common non pharmacological measure adopted by the subjects was salt restriction in diet (87.5%), among males most common measure was exercise (100%) where as Page 17

4 in females salt restriction was the most common medication to control their BP, 7 of them had measure adopted (100%). Any other system of practiced Salt restriction. Cutler, et al. [11] in medicine other than allopathic system was not their analysis of 23 randomly controlled trials used by study subjects as per Table - 3. showed that 100 mmol/day reduction in sodium intake was associated with a decline of 5.7 Discussion mmhg SBP and 2.7 mmhg DBP in hypertensive subjects and 2.2 mmhg/1.3 mmhg in The successive reports of the Joint National normotensives. Others also observed the similar Committee on prevention, detection, evaluation findings [8, 12]. and treatment of high blood pressure (HBP), non drug therapy is recommended as it has long Physical activity in the form of exercise was been considered efficacious [8]. In addition, adopted by 5 individuals in our study. Today, reports on primary prevention of HBP including physical exercise is considered as an important the primary prevention of essential component of the non drug treatment of hypertension (report of a WHO scientific group) hypertension. Physically active persons have [9] and National High Blood Pressure Education lower blood pressure, reduced risk for Program s (NHBPEP) working groups report on cardiovascular and all cause mortality and live primary prevention of hypertension [10], have longer. The benefit of physical activity to the stressed on the non drug therapy. primary prevention of hypertension has been documented by both clinical trials and The JNC VII criteria to diagnose hypertension longitudinal studies [13, 14, 15]. were put forth way back in In the present study, we observed that 54 were diagnosed to Smoking independently raises BP, although have hypertension by JNC VII criteria where as epidemiologically the relationship between 61 by our criteria in a study of mere 310 smoking and hypertension is often confounded subjects. Difference between JNC VII and our by other factors such as alcohol consumption criteria was in the last part of JNC VII definition and lower consumption of fruits and vegetables of hypertension i.e. treatment by anti (anti-oxidants) amongst smokers than non- hypertensive medicines; our criteria comprised smokers [8]. of this statement as any anti hypertensive measure. Seven patients were non JNC VI report [16] found no support for the use hypertensive by JNC VII but diagnosed to have of relaxation techniques for the prevention of hypertension by our criteria. Issue would look hypertension. Yoga, meditation (mind-body more relevant and serious when this aspect is techniques) are widely practiced for stress applied to the bigger population of our reduction in India. In our study also 3 subjects communities where they practice non adopted such techniques to reduce their blood pharmacologic measures to live healthy. It can pressure. BP lowering effect of transcendental be said that we are underestimating the actual meditation has been further supported by two burden of hypertension. How policies can be meta-analyses; analyses; each suggesting TM can reduce made to manage a public health problem both SBP and DBP. without knowing its actual magnitude! Several clinical studies Viz. Framingham off- It was observed in our study that out of 8 spring study [19], INTERSALT study [20], TOPH-I, subjects who adopted non pharmacologic II [21, 22] have shown direct benefit of weight Page 18

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