When performing a Synchro Summon, all of the Synchro Materials used for that Synchro Summon are sent to the Graveyard by game mechanics before the Synchro Monster is Synchro Summoned. At least one of the Synchro Materials must be a Tuner monster.

Some Synchro Monsters require their Synchro Materials to have specific properties. If the Synchro Monster requires Synchro Materials of a specific Attribute (like "Hydro Genex"), a monster with multiple Attributes (such as "Elemental Mistress Doriado") can be used as such a Synchro Material.