The Sceptile amiibo, like all other amiibo, is compatible with Hyrule Warriors II. Like most other amiibo, the Sceptile amiibo does not have unique content attached to it, instead just granting a random award when used. Scanning the Sceptile amiibo will grant the player a random material, a random weapon rated three stars or lower, a single Rupee, or a random amount of Rupees between 100 and 2500.

Scanning the Pokkén Tournament 2 amiibo card of Sceptile will grant a small bonus to Sceptile's stats for local play. In addition, it will unlock Sceptile's alternate palette swap for use in single player local play, instead of being exclusive to "mirror matches" (matches where both fighters are the same character). After its initial use, Sceptile's amiibo card will act as any other amiibo, unlocking a random title or customization option for the player's avatar character.