I have been using the quad mix very successfully but was advised to use it only three times weekly. I must admit I have tended to use it more often. has anyone had experience using this or the trimix at a more frequent rate. If so how often. I have been using it for about 4 months. how many years has anyone been using it. any advice would help but I think it is a wonderful thing. no problems once I got the technique down

If I'm not mistaken - the reason to NOT over use the product is to avoid scar tissue that could lead the the "what ya call" it disease where your penis can be crooked/bent and maybe unusable for intercourse.

It would be best if you start a new thread, and give us your PCa background, so that guys with similar experience can chime in to help.

I would say that going from 20 to 30 in one step could be very risky. My uro advises steps of no more than 10%. For me, a change from .10 to .13 was enough to generate a departure for the emergency room.

Did your Uro work with you on the first injection, and coach you on method & amounts?Moderator - Prostate Cancer(Not a medical professional)

I am not at all sure of the exact mix. I just picked up the Rx. I use the quad mix at the same time cialis daily and viagra. It seems to work just fine. I get an erection that last 2 hours minimum. The question is is the cialis and viagra interfering with the function of the quadmix and causing it to become less available. if I did not use the viagra/cialis would the erection last longer. I am not sure as I know one of the ingredients of the quad mix is closely related to the ingredients in viagra and cialis. I guess the proof is that it works fine. I have discussed frequency of usage with the ED specialist at my urologists office and she says that she has patients that use it daily. My hope would be to use it as often as I wish. which I intend to do.

Thanks for the reply. In answer to your question, I think almost all ED experts, doctors and experienced users would say to not use an injectable with the pills. Given that you are doing so, I will have to guess you have been very fortunate that you haven't gone over 4 hrs, and had to got to the ER for a reduction. Since you don't know the ingredients of the quad mix, it's impossible to say if the drugs are like or similar. I'd suggest first to ask your prescribing doctor about using the pills with the injections. Second, I'd ask the doctor or the compounding pharmacist to write down for you the exact chemical names and the amount per ml of each of the 4 drugs. Then you should be able to tell about like drugs and such.

I believe the pill increase the blood flow to the penis and thus might decrease the duration of the erection by increasing the washout of the med. the proof is in the facts. I wil try to use it without the drugs and see what happens. it may actually increase the erection time. but we will see

Actually, all the drugs we are talking about here do more or less the same thing.* They all work to relax the smooth muscles in the arteries in the corpus cavernosum. The injectable drugs do so directly. They act on the arterial walls to make them relax which lets your blood pressure make the arteries inflate. The pills suppress an enzyme called Phosphodiesterase 5 that destroys cGMP which is the substance that your body releases when you are sexually excited... to relax those same smooth muscles in the arteries in your Johnson.

You might ask your urologist if combining the quad mix with the Viagra is really doing much for you. You might be able to get the same bang (so to speak) for fewer bucks if you skipped the Viagra on quad mix days and adjusted the dose to compensate.

Of the three drugs used in Trimix -- Papavarine, Phentolamine, Alprostadil (aka Prostaglandin) -- the best one is the Alprostadil. It gives the strongest effect with the smallest dosage and has the fewest side-effects overall. Unfortunately, it does have one problematic side-effect for some men: it hurts.

If you are one of the one men in three for whom prostaglandin causes a pain response you won't be able to use it as a single ED drug (Caverject and MUSE will be a problem) and the relatively smaller amount in Trimix may still give you an ache. If it does you can try Bi-mix (w/o the Alprostadil) but it doesn't work as well and, at an effective dose, tends to have more of the other side-effects.

Another option is to add a dab of anesthetic to the mix (I think it is usually Lidocaine). This numbs the nerves to the corpus cavernosa but doesn't tend to affect the penile sensory nerves as much. My urologist gave me a scrip for some but I haven't filled it yet since I still have a few weeks of my previous Trimix formula on hand and I am too cheap to throw it away -- I'll just play through the ache until the vial is gone.59gradual PSA rise 2007-2012 from 1.4 to 8four biopsies 2010-2012:1)negative (inflammation observed),2)negative,3)positive in one of 14 cores GS6(3+3) 3-4%, 2nd opinion gs7(3+4)4)negative.DaVinci RRP 6/14/2012positive margins in apex and 1mm margin in base. GS9(4+5)Started 24 mo ADT (Triple w/ Lupron) 7/26/12sched for adjuvant radiation therapy

Great answer and good reasoning on the medical aspect. Be sure to let us know when you do try it, I'd be interested in knowing if the ache is gone and how you feel and respond to a little numbing.. James C, 65, A Better Man/Injections? Read This4/07: PSA 7.6, 3/16 PCa, 5% inv, lf. lobe, GS69/07: open RP, Path: pT2c, 110 gms., Prob. micro.inv.-left apical margin -GS65 Yrs: .04 'til 4/10-.06, 12/10-.09, 5/11-.08, 9/11-.14, 2/12-.10, 7/12-.13

lidocaine would be the best choice since it is also a vasodilator, another possible ingredient to add would be duraclon which is injectable clonidine. Phentolamine and clonidine are specifically alpha blocker drugs which means more arterial rather than venous dilation. Phentolamine is more medically limited in use compared to old days when we used it to improve blood flow to distal limbs that were ischemic. Clonidine is costly but used in Europe. Lidocaine makes total sense to include in any injection. Prior to prosthesis placement but under anesthesia (my occupation), I have watched urologists inject 20-30 mls of normal saline to determine erection size and then chosen the appropriate prosthetic appropriately. Dorsal penile nerve blocks are done to provide pain relief, but they do also augment blood flow by blocking sympathetic nerve fibers. The anti-dotes for priapism are drugs that increase sympathetic tone such as cough meds. Lidocaine and alpha blockers are mainstays from my perspective of injectables, not sure about the atropine.

Welcome to the forum, Finish Strong, and thanks for the interesting observations.

What brings you to our forum? We focus primarily on prostate cancer but we will frequently have discussions on topics (such as this thread on intercavernous injections for ED) that deal with side effects of PCa treatments that are also of general interest to people outside our usual pool of participants. In any event, welcome, and if the reason you found yourself here is something you'd like to talk about feel free to say so, either by commenting further on this thread, starting a new thread or sending me an email (click the envelope icon under my name on the left).

Since you are a medical professional, you should remember that you are not participating in this forum in that capacity. It's not that we don't value your knowledge, its just that we don't want to find ourselves up to our keisters in lawyers.60 Slow PSA rise 2007-2012: 1.4=>84 bxs 2010-2012:1)neg (some inflammation),2)neg,3)positive 1 of 14 GS6(3+3) 3-4%, 2nd opinion GS7(3+4)4)neg.Mild Pre-op EDDaVinci RRP 6/14/12. left nerve sparedPath: pT3a pN0 R1 GS9(4+5) Pos margins on rtStart 24 mo ADT3 7/26/12Adjuvant IMRT 66.6 Gy 10/17/12 - 12/13/12Leaky but better, Trimix, VEDForum Moderator - Not a Medical Professional

Husband (age 62): Da Vinci on May 9, 2013Gleason: 3+314 core biopsy: 1 small spot of cancer found on one core.Pathology good: cancer contained in the prostate, Gleason did not change.3 month PSA: njw_753@yahoo.com

I am not a member of the medical industry and anything I say is not intended or implied to be a substitute for professional medical advice, diagnosis or treatment.

I see that now. It was FinishStrong's post that made me think it was a new thread.Husband (age 62): Da Vinci on May 9, 2013Gleason: 3+314 core biopsy: 1 small spot of cancer found on one core.Pathology good: cancer contained in the prostate, Gleason did not change.3 month PSA: I am not a member of the medical industry and anything I say is not intended or implied to be a substitute for professional medical advice, diagnosis or treatment.