Spotlight on: Linebacker Aldon Smith. The 49ers’ first-round pick has 5 1/2 sacks in his past three games, but his hot streak will be challenged against Browns left tackle Joe Thomas, regarded as one of the NFL’s best offensive linemen. Smith will enter in passing situations and he typically has lined up at right defensive end this season, meaning he figures to see plenty of Thomas, the No. 3 pick in the 2007 draft who has earned Pro Bowl honors in each of his first four seasons.

Injury notes: 49ers – WR Braylon Edwards (knee) is expected to be a game-time decision; Ted Ginn could make his second start of the season, regardless of Edwards’ availability; backup CB Tramaine Brock (hand) is doubtful, and rookie Chris Culliver (shoulder), the No. 3 cornerback, is probable. Browns – RB Peyton Hills (hamstring) is questionable and would be replaced by Montario Hardesty (73 carries, 238 yards); WR Mohamed Massaquoi (concussion) is out and will be replaced in the starting lineup by Josh Cribbs (15 catches, 192 yards).

Keys to a 49ers victory

1. Dominate an inert offense: The Browns, coming off a 6-3 win against the Seahawks, rank 23rd in the NFL in total offense (308. 3 yards) and 27th in points per game (16.2). The 49ers have allowed 25 points in their past 10 quarters. This shouldn’t be a fair fight.

2. Contain Josh Cribbs: Cribbs, on special teams, could represent the Browns’ best offense. Cribbs, who has 10 returns for TDs in his career, ranks 12th in the NFL in both kickoff and punt returns this season.

3. Avoid the post-bye-week blues: Teams are 3-9 after their byes this season, and the 49ers are coming off an extended six-day break from practice. This is the first game in which they’ve been overwhelming favorites this season. Will they play with the same edge in their new role as one of the NFL’s early-season darlings?