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Genetic Engineering & Biotechnology NewsThermal self-regulating nanoparticles that seek out and destroy cancer cells may sound like something pulled from the new Blade Runner movie script, but researchers at the University of Surrey have developed the therapy for use today. The "intelligent" nanoparticle, which heats up to a temperature high enough to kill cancerous cells, self-regulate and lose heat before they get hot enough to harm healthy tissue. Findings from the new study could soon be used as part of hyperthermic thermotherapy to treat patients with cancer.READ MORE

The JAMA NetworkBefore breast augmentation or reconstruction, surgeons need to convey the risk of breast implant-associated anaplastic large cell lymphoma to patients, with particular emphasis on the established linkage to textured implants; patients must be educated on the importance of routine surveillance after implantation, and it is likely that increased follow-up will lead to a further rise in this diagnosis.READ MORE

The Medical NewsThe mechanism of how cells work is key to understanding how tumors metastasize as well as tissue regeneration and other bodily functions. The process of mechanotransduction, or how a cell converts a physical stimuli into an electrical response is fundamental to these understandings.READ MORE

MedPage TodayAfter 6 months of treatment and a grueling eight rounds of chemotherapy, Matthews's lymphoma had stopped responding to medicine's best efforts. For most patients, that's the end of the line. Matthews's doctors, however, gave him one more option. It would involve siphoning out his white blood cells and sending them on a cross-country expedition so genetic engineers in a factory outside Los Angeles could train them in the ways of cancer killing. The cells would be rewired and nurtured in an incubator, then frozen and shipped to Boston to be dripped back into his veins.READ MORE

The Medical NewsIn the body, cells move around to form organs during development; to heal wounds; and when they metastasize from cancerous tumors. A mechanical engineer at Washington University in St. Louis found that cells remember the properties they had in their first environment for several days after they move to another in a process called mechanical memory. Amit Pathak, assistant professor of mechanical engineering & materials science in the School of Engineering & Applied Science, spent three years using mechanobiology and materials science to find answers to these questions: If cells sit in one environment and move to another one, do they remember the first one, and do they inherit any of the properties of the first environment?READ MORE

Modern MedicineThe phase II SARC028 study found that the immunotherapy agent pembrolizumab has meaningful clinical activity in patients with two subtypes of advanced sarcoma. This included undifferentiated pleomorphic sarcoma and dedifferentiated liposarcoma, while other subtypes including Ewing sarcoma and leiomyosarcoma did not respond to the therapy.READ MORE

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The Medical NewsAn infusion of cells from a child's own umbilical cord blood appears to improve brain connectivity and motor function in children with spastic cerebral palsy, according to a randomized clinical trial published recently by Stem Cells Translational Medicine.
The placebo-controlled, phase two trial included 63 children with varied types and severities of spastic cerebral palsy, a condition usually caused by brain damage before or at birth. Children who received one intravenous dose of at least 25 million stem cells per kilogram of their body weight saw improvements in motor function a year later.READ MORE

University of Pennsylvania School of Medicine via ScienceDailyScreening for tumor cells in the fallopian tubes of women at high-risk for ovarian cancer may help detect the cancer years before it develops further, suggests a new study. The work traces the origins of high-grade serous ovarian carcinoma, the most frequent type of ovarian cancer that is often diagnosed at advanced stages, back to fallopian tube lesions known as 'p53 signatures' and serous tubal intraepithelial carcinomas that harbor the TP53 gene mutations.READ MORE

Genetic Engineering & Biotechnology NewsBy now, if you aren’t aware of the association between smoking and lung cancer, then it is possible you may have just awoken from some Van Winkle-esque spell, as tobacco smoking is the most well-known environmental risk factor associated with lung cancer. Now, new evidence from investigators at Dartmouth College has cemented the interactions between genes and smoking, underscoring the fundamental role smoking plays in the etiology of lung cancer.READ MORE

Laboratory EquipmentBy combining engineered polymeric materials known as hydrogels with complex intestinal tissue known as organoids – made from human pluripotent stem cells – researchers have taken an important step toward creating a new technology for controlling the growth of these organoids and using them for treating wounds in the gut that can be caused by disorders such as inflammatory bowel disease.READ MORE

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The NSH membership community is made of individuals actively engaged in all aspects of the histology field, as well as others with past or future interest in histology, such as students and retired professionals. Together, we are more than 3,000 members strong and growing, working as an organization to strengthen the histology profession through quality education and professional relationships to enrich and grow careers. To find out more on how to join NSH, click here.