All of us in the pharmacometrics community owe a debt of gratitude to Lewis, Stuart, Alison, and the many others who were involved in the development of NONMEM. The program has proven to be of tremendous value in dealing with the challenges we encounter in pharmaceutical research and development. NONMEM has truly changed the landscape and – really – we are only at the beginning of a new era of model-driven R&D.

A historical perspective from Alison Boeckmann – One of the developers and programmers of NONMEM