VISOMITIN (Skulachev Ions | SKQ1 eye drops)

Customer Reviews

Dosage and administration Dosage is 1-2 drops 3 times a day. Duration of treatment determines Ophthalmologist individually, depending on the severity of symptoms and the dynamics of the pathological process in the eyes, it is generally a period of time from several months to six months. During complex treatment of senile cataract held periodic medical examination ophthalmologist to appoint a possible surgical intervention on the lens of the eye. Side effects As a side effect after application and can develop local reactions in the eye in the form of a burning sensation, cramps, redness of the conjunctiva. Rarely can appear systemic allergic reactions such as skin rashes, itching it, urticaria (a characteristic rash and swelling, which in appearance resemble the sting). Cases of severe allergic reactions in the form of angioedema angioedema, or anaphylactic shock (a progressive decrease in systemic blood pressure and organ failure) were not observed.OverdoseData on overdose with topical application as well as information about the accidental or intentional ingestion of the drug there.

Contraindications

Using eye drops Vizomitin contraindicated in case of individual intolerance or hypersensitivity to the active ingredient and auxiliary ingredients. Also, the drug does not apply to children under 18 years.

A few years ago a small molecule SkQ1 was synthesized by the group of professor Vladimir P. Skulachev in the Moscow State University. One part of SkQ1 functions as a molecular “tow truck” carrying the other part of the molecule – an extremely active antioxidant plastoquinone – into mitochondria. Both theoretical calculations and experimental results showed that SkQ1 was delivered into the mitochondria in an extremely targeted and efficient manner. The physics of the mitochondrial membrane and the unique properties of SkQ1 direct it into the inner leaflet of the inner mitochondrial membrane with high precision.

The presence of SkQ1 in mitochondrial membrane enables mitochondria to protect itself from reactive oxygen species (ROS) by breaking the chain reaction of lipid destruction. This ability of the lead molecule to protect cells against oxidative stress is the key in treating patients suffering from various age-related disorders such as cardiovascular diseases, neurodegenerative disorders and ophthalmic conditions.

It has been hypothesized that age-dependent accumulation of oxidative damages in living organisms may be the main cause of ageing process. It might be possible to control this damage accumulation through controlling the level of ROS production in mitochondria. It is important to stress that ROS production should be controlled, not stopped, so that ROS can still fulfill a number of crucial biological functions. For instance they fight bacteria and viruses, both directly – via elimination of pathogens, – and indirectly – via regulation of the immunological response to infection through triggering apoptosis (cell death).

Antioxidants are a well−developed pharmacological approach to fight against ROS. A possible role of antioxidants in controlling ageing process has widely and for a long time been discussed with ambiguous conclusions, ranging from the statement of the American biochemist Prof. Bruce Ames and colleagues on finding a new anti−ageing therapy with a 100% positive result to D. Howes’s implication of the utter barrenness of this method, and, therefore, of total failure of Harman’s “free radical” hypothesis. According to Dr. Skulachev the antioxidant−based ageing control approach has some significant flaws.

The “ideal” antioxidant should be specifically targeted to mitochondria where ROS are produced and it should effectively remove not all the ROS but just their excess. It is also important for an antioxidant not to be toxic and not to be recognized and eliminated by cell enzymes.

With these criteria fulfilled, a successful anti-oxidant compound should be able to prevent/repair oxidative damage in organism and prevent/treat many age-related disorders across various therapeutic areas.

The mechanism of action of SkQ1 involves at least two extremely complex and novel concepts: delivering a compound inside mitochondria and reducing ROS production inside mitochondria in a controlled and sustainable manner. SkQ1 molecule successfully addresses these two aspects as our experimental work has shown.

More than a dozen studies have been conducted and showed SkQ1 effectiveness in such critical therapeutic areas as the following:

ACTOVEGIN ®

$27.00

Many decades ago shepherds in Switzerland noticed that young calves are able to heal their injuries and regenerate their tissue much faster than older calves. However, it was only in 1957, when Swiss scientists obtained a highly purified extract from blood of young calves and developed the drug.Actovegin enhances aerobic oxidation, absorption of glucose and oxygen uptake in tissue. For this reason Actovegin has been used by athletes who wanted to speed up the recovery process and enhance physical performance and stamina. It is also a great drug to treat various sport injuries.

Aralia Tincture

$10.00

Aralia is a well-known gentle adaptogenic tonic herb popular for its wide range of pharmacological properties. It is used to treat physical and mental fatigue, asthenic syndrome, arterial hypotension, decreased sex drive, mental breakdown, depression, enuresis, radiation sickness and metabolic disorders. This herbal remedy can also help to recover from craniocerebral injury, contusion, meningitis, post-infectious arachnoiditis and ARVI (in the complex therapy).

BEMITIL [Metaprot]

$9.00$15.00

Developed in the Soviet Union for the needs of the military, Bemitil (also known as Metaprot and AntiHot) has a long history of usage in clinical practice and in sport. It was developed in the 1970s and was successfully used during Afghanistan war, Chernobyl catastrophe and Olympic games in Moscow.

The drug has nootropic, regenerative, antihypoxic, antioxidant and immunomodulatory action.