Summary: The effect of the antitumor agent Ukrain
on the growth kinetics of the experimental tumor sarcoma-45 was studied by correlation
analysis. Sarcoma-45 was implanted into 28 Wistar rats in the subcutaneous layer
of a lateral site of the trunk. Fourteen animals received i.v. Ukrain every
other day in a dose of 30 mg/kg (0.1 LD50). The other 14 rats served
as controls. Macromorphometry of the tumor nodes of sarcoma-45 was carried out
every day in both groups. Statistical analysis of morphometric data and plotting
of histograms were performed. Regression equations were selected and their parameters
determined. A mathematical model was assessed. The effectiveness of Ukrain treatment
was analyzed using the equivalent exponent method. Ukrain was proved to be an
effective antitumor agent on biological and mathematical models in accordance
with standardized instructions for screening.