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Definitely coloboma - although I never heard of it being conditional with light. When her eye is dilated it must just not be as noticeable. Since the sphincter pupillae muscle is interrupted it may only be noticeable during contraction / bright lighting.

Maybe not damaging, but her eyes could be more sensitive to light. More of an annoyance I guess. Sort of like using too large of an aperture on a camera. Although it wouldn't be that bad because it's just left open near the bottom. I think ~90% of coloboma cases involve the defect in that location. Very rarely are they more lateral/sideways or superior/on top.

Yup, basically what has happened is that her choroidal fissure did not fuse properly during development so there is a large hole right into the retina. Like having a massively dilated eye all the time, too much light will damage the photoreceptor cells in the retina.

Or is it just not noticeable in low lit environments? It would make sense if it were less noticeable when her pupil was dilated. Such is the case with coloboma (in theory... I'm an anatomist, not a doctor)

It's definitely a coloboma, I'm a medical student and have worked the past two months in ophthalmology and have seen this a couple of times, its quite rare. The position of where the gap in the pupil is what makes it identifiable as such, described as "keyhole", a very apt choice. To explain, when the eye is forming, it starts at the top and encircles around to the bottom (it's hard to explain without a picture. Sometimes it doesnt quite meet at the bottom and it can affect the retina and other things depending on the severity. here's some more information in case your friend is interested.
http://www.rnib.org.uk/eyehealth/eyeconditions/conditionsac/Pages/coloboma.aspx

I'm under the impression that any other co-morbidities associated with the disease will manifest themselves quite early, CHARGE being the main example of syndrome that is not limited to one system, however coloboma can be part of a spectrum disease called the microphthalmia-anophthalmia-coloboma spectrum which can lead to optic cysts. If they haven't already, I'd pencil in an appointment with an ophthalmologist (or eye doctor as you yanks say) to ensure there's no background pathology at the back of the eye. Genetic testing is sometime advised for future genetic counselling (for more severe cases really) and sometimes an MRI scan and an ultrasound scan may be needed to exclude neurological defects and determine prognosis, however the physician can decide and advise as to what is required. If the person in question is not symptomatic then there is probably less too worry about, but it's best to check. I hope that helps :)

It's cheaper because it goes at Sorcery speed, rather than the others being Instant speed. If it had the 1B mana cost, it would be strictly worse than cards like Terror or Doom Blade, even if it became an instant.

This is not an example of imbalance, as others have said it is a sorcery rather than instant, but even if it was an instant, it would not be overpowered.

Some colours (black and red) get cheaper costed removal spells because that is traditionally that is one of their strengths. The other colours would get discounts on other types of spell (blue with it's counters, white with lifegain etc).

Also, below you mention the Vampire Nighthawk as unbalanced, but really it is pretty mediocre in constructed play. Lifegain is fairly irrelevant unless, as gaining life doesn't win you the game, and still you are paying 3 mana for 2 power, when you could be paying one mana.

In limited play which is a very popular way to play, it would be a much better card, due to the style of play of most limited decks. When WOC design a set of cards, they do not intend to balance them all to be equal to each other for all instances, but rather they design for both limited and constructed play, competitive and casual.

Also, Magic is a pay to win game as much as golf is a pay to win game, you pay for better equipment (cards/clubs), but this doesn't mean that money is the deciding factor. Just like spending a ton of money on fancy clubs wont let you beat Tiger Woods (even though he is using some random no name scrub clubs), having tons of money to buy cards doesn't give you that much of an advantage against a good player.

There's actually a condition for this. I remember another thread where someone posted a similar picture and a bunch more people posted their own iris's that were weird. I'm too lazy to find it though, I'm sure someone out there knows what I'm talking about.

Alas, I do not wear hats. Again, there is absolutely nothing wrong with the subject material and I think the picture is really cool, but if it was clear it would be absolutely stunning. I am not sure how I am not conveying this clearly enough. I really, really, like the picture. In fact, I was one of the 73%.

I meant that in an endearing yet reserved fatherly manner like when you win the little league championship and your grizzled father hides a tear and when you ask him if you did good he replies, "you did alright, son. You did alright."

So I saw in another comment you already said you took it with your phone, so I won't bitch too much about the clarity of the picture, however I will say this: learn what macro is. Even most phone cameras have that in the options. It tells the camera you're going to take a close up picture and to make the focus point as close as you can. If its not built into your default app, there are some free ones out there that have it you can get from the app store.

Ya it's a coloboma. More prominently visible when there is bright light causing the iris to constrict. Usually they are random but they can be associated with some genetic syndromes. You can also get colobomas of the retina, eyelids, or optic disc, basically it just means the absence of a normal part of ocular anatomy.

I'm not saying the title isn't possible, but couldn't an explanation of this "running pupil" also be that the supposed pupil is just a reflection of the person taking the picture? That's what it looks like to me anyway; or maybe her pupil "runs" when it's too bright.

True enough. And it does reflect a sort of quiet chuckle that many people do at the end of a spoken sentence - so it may be warranted, in a sense. But I can't help feeling that some part of me will always cringe a little when I see 'lol' anywhere outside of a text message.

Furthermore, who is to say that earlier change-resisters were so wrong? Reading Shakespeare, for instance, it's hard not to feel that there was maybe some latent beauty in Early Modern English that we've lost today.

Yes, Shakespeare was writing for the stage, which certainly would not be quite how people would speak in practical circumstances. And yes, very pretty writing can be seen in some contemporary writing as well; but that sort of eloquence isn't seen in every-day speaking or writing today either.

I guess my point (if I even have one - this is more just thinking aloud) is that language is inherently flexible; interesting, eloquent, evocative, just downright good writing is possible in any language, and I wish more people (myself included!) cared more about the way they speak and write, and tried to make more use of everything language has to offer.

my girlfriend always told me i have a lollipop eye... this makes soooo much sense now... mine is not as extreme as these though. Although the eye i have it in is like 40/60 i think. Which im pretty sure is bad???

OMG I knew this condition exists. I told my pharmacist and doctor friends about this and they all said that nothing like this exists but I knew someone with this. I knew I'm not crazy. IT EXISTS IT EXISTS

I have this too except mine is visible at all times. It used to be larger when I was younger and my parents took me to a bunch of different optometrists to try to find out what it was. I remember quite a few doctors asking me if I was blind in that one spot in my eye and that it would be ok to tell them the truth if I really were blind. Uh, no. Not blind, sirs. We got no answer and to this day I still don't know what it's called - I just go with a "deformity of the pupil". It's cool to see someone else with this too!

I haven't read all of the comments and this may have already been addressed, but I thought I should pass along some information. The pupil is actually a HOLE behind the lens of the eye. If it is misshapen, there is a problem that should be checked out by an eye doctor.