PBK (Protein|Antibody|cDNA Clone|ELISA Kit)

Recombinant PBK proteins are expressed by Baculovirus-Insect Cells with fusion tags as C-His.

PBKantibodies are validated with different applications, which are ELISA(Cap), ELISA, WB, ELISA(Det).

PBKcDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each PBK of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.

PBKELISA Kit are quality controlled by 8 internation QC standard which guarantee every ELISA Kit with high quality.

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PBK related research area

PBK background

PDZ binding kinase (PBK), also known as TOPK (T-LAK cell-originated protein kinase), is a serine/threonine kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family, and has all the characteristic protein kinase subdomains and a C-terminal PDZ-binding T/SXV motif. PBK is expressed in the testis restrictedly expressed in outer cell layer of seminiferous tubules, as well as placenta. PBK may be enrolled in the activation of lymphoid cells and support testicular functions, with a suggested role in the process of spermatogenesis.This mitotic kinase phosphorylates MAP kinase p38 and seems to be active in mitosis. When phosphorylated, PBK forms a protein-protein interaction with tumor suppressor p53 (TP53), leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage. The expression level of PBK is thus upregulated in a variety of neoplasms including hematological malignancies.