Arylsulfatase A (ASA) is a lysosomal enzyme whose primary physiological function is desulfation of cerebroside sulfate. Deficiency of ASA leads to metachromatic leukodystrophy (MLD) with different ages of onset. Some healthy individuals also show...

Let $(X,\chi)$ be a measurable space, let $M = M(X,\chi)$ be the space of nonnegative, bounded measures on $(X,\chi),$ let N be the subset of M with integer values, let ${\cal M}$ be the smallest $\sigma$-algebra on M with respect to which the...

A7r5 cells were employed to delineate the relationship between cell proliferation and voltage-gated Ca$\sp{2+}$ entry in vascular smooth muscle cells of the noncontractile, synthetic phenotype. The main hypothesis tested was that Ca$\sp{2+}$ entry...

A site-specific mutant of P450 BM-3 (P450 102) from Bacillus megaterium with the Phe87 residue replaced by gly (F87G) has been expressed in E. coli and found capable of catalyzing the oxidative cleavage of the naphthylmethyl group of...

Deterministic Numerical Optimization methods that are used in Science and Engineering have several short-comings that limit their applicability. If the phenomena that cause a deterministic Numerical Optimization method to fail are known, then it...