inhibitory potency for morphine uptake was affected by the OCT1 (显示 POU2F1 ELISA试剂盒)*2 allele. OCT2 showed only a limited uptake of ranitidine that was not significantly affected by the Ala270Ser polymorphism

The combination of ENT1, MATE1 and OCT2 SNPs may serve as a predictive and prognostic marker in metastatic colorectal carcinoma patients treated with TAS-102.

This study of SLC22A2 contributes in filling the gap that exists with regards to genetic information about important variations in organic cation transporter genes for the indigenous populations of South Africa.

Findings identify OCT2 as a genetic factor that directly impacts on the molecular and hormonal events taking place during acute stress, accentuating the noxious effects of repeated stress on the development of stress-related phenotypes

Molecular components of the circadian clock regulated the renal expression of Slc22a2, which resulted in rhythmic oscillations in OCT2 protein levels.

Cellular uptake of oxaliplatin increases by 16- to 35-fold in cells overexpressing Oct2, a process associated with increased DNA platination and oxaliplatin-induced cytotoxicity.

Antigen Summary

Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. It is found primarily in the kidney, where it may mediate the first step in cation reabsorption.