Levonor General Information

The active sympathomimetic hormone from the adrenal medulla in most species. It stimulates both the alpha- and beta- adrenergic systems, causes systemic vasoconstriction and gastrointestinal relaxation, stimulates the heart, and dilates bronchi and cerebral vessels. It is used in asthma and cardiac failure and to delay absorption of local anesthetics. .[PubChem].

Medicinal name:

Levonor - Pharmacology:

Levonor works via the stimulation of alpha and beta-1 adrenergic receptors, and a moderate activity at beta-2 adrenergic receptors.

Levonor Interactions

Levonor should be used cautiously in patients with hyperthyroidism, hypertension and cardiac arrhythmias. All
vasopressors should be used cautiously in patients taking monoamine oxidase (MAO) inhibitors.

Levonor should not be administered concomitantly with other sympathomimetic drugs (such as isoproterenol)
because of possible additive effects and increased toxicity.

Combined effects may induce serious cardiac arrhythmias. They may be administered alternately when the preceding
effect of other such drug has subsided.

Administration of epinephrine to patients receiving cyclopropane or halogenated hydrocarbon general anesthetics
such as halothane which sensitize the myocardium, may induce cardiac arrhythmia.. When encountered, such arrhythmias
may respond to administration of a beta-adrenergic blocking drug. Levonor also should be used cautiously with
other drugs (e.g., digitalis, glycosides) that sensitize the myocardium to the actions of sympathomimetic drugs.

Diuretic agents may decrease vascular response to pressor drugs such as epinephrine.

Levonor may antagonize the neuron blockade produced by guanethidine resulting in decreased antihypertensive
effect and requiring increased dosage of the latter.

Levonor Contraindications

Levonor is contraindicated in patients with known hypersensitivity to sympathomimetic amines, in patients with
angle closure glaucoma, and patients in shock (nonanaphylactic). It should not be used in patients anesthetized with
agents such as cyclopropane or halothane as these may sensitize the heart to arrhythmic action of sympathomimetic
drugs.

Levonor should not ordinarily be used in those cases where vasopressor drugs may be contraindicated, e.g., in
thyrotoxicosis, diabetes, in obstetrics when maternal blood pressure is in excess of 130/80 and in hypertension and
other cardiovascular disorders.