Anti-MFG-E8 (Mouse) mAb

Background

Apoptotic cells are rapidly removed
by phagocytosis to clear the living cells and tissues of
intracellular materials being released from dying cells.
Phagocytes recognize apoptotic cells through milk fat
globule-EGF-factor 8 (MFG-E8). MFG-E8 is a secreted
glycoprotein from thioglycollate-elicited macrophages and
bind to phosphatidylserine exposed on the cell surface of
apoptotic cells, then bind strongly to cells expressing αvβ3
integrin via its RGD (arginine-glycine-aspartate) motif.
Thus, MFG-E8 is an important protein to mediate the
engulfment of apoptotic cells by activated macrophages.