Cordis to Present Data Supporting Cypher at TCT 2007

October 18, 2007 - Cordis Corp. will present clinical data backing the CYPHER Sirolimus-eluting coronary stent at the annual Transcatheter Cardiovascular Therapeutics 2007 meeting (TCT 2007), which will take place in Washington, D.C. from October 20-25. Data from several studies will highlight the CYPHER Sirolimus-eluting Coronary Stent, as well as other products from the company’s peripheral vascular group.

“The studies that will be presented at this year's meeting will continue to add to the significant body of scientific evidence for the CYPHER Stent and our diverse portfolio of current and future products, which range from a carotid artery stent system to a wound closure device," said David E. Kandzari, M.D., F.A.C.C., F.S.C.A.I., Chief Medical Officer, Cordis Corporation. "The studies and presentations will further validate the clinical advantages of drug-eluting stents compared with bare metal stents, highlight economic data of stenting versus surgery, and feature the clinical benefits of the CYPHER Stent versus the Taxus Stent."

Barry T. Katzen, M.D. of the Baptist Cardiac and Vascular Institute in Miami, Florida will present a pooled analysis of three carotid artery stenting trials to assess 30-day major adverse events rates, comprising death, all stroke and/or heart attack (myocardial infarction), in high-risk patients based on anatomic versus physiological risk factors. The analysis was pooled from the pivotal SAPPHIRE randomized and registry stent cohorts and the CASES-PMS study, which involved the PRECISE Stent and ANGIOGUARD Emboli Capture Guidewire.

No previous analysis has been reported regarding whether patients undergoing carotid artery stenting with emboli protection, who are at high-risk for carotid endarterectomy, have a higher risk for major adverse events based on anatomic versus co-existing physiological risk factors prior to carotid stenting. Additional analysis assessing one-year outcomes of these subgroups will also be presented.

3:32 p.m. ET

Oral Presentation - ECLIPSE Trial

Room 202B

S. Chiu Wong, M.D. of New York-Presbyterian Hospital/Weill Cornell Medical Center will present perspectives on extravascular sealing devices and a first report of the ECLIPSE Trial, a multicenter, non-blinded, randomized study designed to measure the safety and efficacy of the EXOSEAL(TM) Vascular Closure Device versus manual compression to close vascular access sites in patients having undergone diagnostic or interventional procedures.

The EXOSEAL(TM) Vascular Closure Device features a synthetic bioabsorbable polymer and is being studied to determine whether it can enable expedited hemostasis (the cessation of bleeding), faster patient ambulation (ability to walk) and reduced bed-stay after a catheterization procedure. Nearly eight million patients undergo cardiac catheterization procedures annually.

SUNDAY, OCTOBER 21

12:51 p.m. ET

Oral Presentation - ACROSS and PRISON II Trials

Ballroom C, Level 3

Dr. Kandzari will present six-month data results of the ACROSS Registry and PRISON II randomized clinical trial designed to evaluate the CYPHER Stent used in patients with chronic total occlusions.

MONDAY, OCTOBER 22

7:00 p.m. ET

Symposium - "New Evidence in DES Outcomes: The Road Traveled Since the World Congress of cardiology 2006"

Grand Hyatt Constitution Ballroom

A panel of distinguished speakers that includes Christian M. Spaulding, M.D., PhD of Cochin Hospital in France; Stephan Windecker, M.D. of Swiss Cardiovascular Center Bern in Switzerland; Jeffrey W. Moses, M.D., of Columbia University Medical Center in New York; and Lowell F. Satler, M.D. of Washington Hospital Center will discuss the drug-eluting stent landscape and how to apply current evidence to clinical practice. Topics of discussion will include the impact of media headlines on clinical practice, the latest data set on percutaneous coronary interventions, applying the evidence of drug-eluting stents to clinical practice and the future of sirolimus-eluting stents.

Jason W. Ryan, M.D., M.P.H. of Beth Israel Deaconess Medical Center in Boston, Massachusetts will present a comparison of pre-drug-eluting stent implantation in 2001 to post-drug-eluting stent implantation in 2004; Dr. Ryan will provide an update on temporal trends, outcomes and costs from this time period associated with coronary revascularization procedures, including percutaneous interventions and bypass surgery, from the Medicare program in the United States.

WEDNESDAY, OCTOBER 24

1:45 p.m. ET

Oral Presentation - ARTS II

Coronary Theatre - Lower Level

Bernard De Bruyne, M.D., Ph.D. of Cardiovascular Center, OLV Hospital, Aalst, Belgium will present two-year data results from the ARTS-II Trial, which compared the safety and efficacy of the CYPHER Stent versus BMS and CABG. Dr. Bruyne will present data from the study assessing the impact of gender following multivessel drug-eluting stent implantation.