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The United States sprinter Florence Griffith-Joyner underwent a similar physical transformation before she put the 100m and 200m records beyond reach, at and respectively, in 1988. She, too, never failed a drugs test, but Carl Lewis, in his autobiography, Inside Track, described her sudden leap from also-ran to untouchable as "a change that came too quickly for the imagination." He added: "Her physical appearance alone – muscles popping everywhere – made a lot of people wonder. Then there was the voice, much deeper than it had been in the past."

Transdermal patches (adhesive patches placed on the skin) may also be used to deliver a steady dose through the skin and into the bloodstream. Testosterone-containing creams and gels that are applied daily to the skin are also available, but absorption is inefficient (roughly 10%, varying between individuals) and these treatments tend to be more expensive. Individuals who are especially physically active and/or bathe often may not be good candidates, since the medication can be washed off and may take up to six hours to be fully absorbed. There is also the risk that an intimate partner or child may come in contact with the application site and inadvertently dose himself or herself; children and women are highly sensitive to testosterone and can suffer unintended masculinization and health effects, even from small doses. Injection is the most common method used by individuals administering AAS for non-medical purposes. [45]