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Pharmacogenetics Flashcards Preview

Pharmacogenetic vs. pharmacogenomics

Genetic basis for variation in drug response include genomics which surveys the genome entirely to asses genetic diversity

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6-mercaptopurine example

Treats childhood acute lymphoblastic leukemia. 1 in 100 children have a variant thiopurine methyltransferase, which prevents 6-MP metabolism drug accumulates to fatal result. Now all children are screened before 6-MP administration