This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

Alternative names

c Raf

C-raf

C-Raf proto-oncogene, serine/threonine kinase

CMD1NN

cRaf

Craf 1 transforming gene

Craf1 transforming gene

EC 2.7.11.1

kinase Raf1

Murine sarcoma 3611 oncogene 1

NS5

Oncogene MIL

Oncogene RAF1

OTTHUMP00000160218

OTTHUMP00000207813

OTTHUMP00000209389

Protein kinase raf 1

Proto-oncogene c-RAF

RAF

Raf 1

Raf 1 proto oncogene serine/threonine kinase

Raf proto oncogene serine/threonine protein kinase

RAF proto-oncogene serine/threonine-protein kinase

RAF-1

RAF1

RAF1_HUMAN

Similar to murine leukemia viral (V-raf-1) oncogene homolog 1

TRANSFORMING REPLICATION-DEFECTIVE MURINE RETROVIRUS 3611-MSV

v raf 1 murine leukemia viral oncogene homolog 1

v-raf murine sarcoma viral oncogene homolog 1

v-raf-1 murine leukemia viral oncogene-like protein 1

vraf1 murine leukemia viral oncogene homolog 1

see all

Function

Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. Part of the Ras-dependent signaling pathway from receptors to the nucleus. Protects cells from apoptosis mediated by STK3.

Tissue specificity

In skeletal muscle, isoform 1 is more abundant than isoform 2.

Involvement in disease

Defects in RAF1 are the cause of Noonan syndrome type 5 (NS5) [MIM:611553]. Noonan syndrome (NS) is a disorder characterized by dysmorphic facial features, short stature, hypertelorism, cardiac anomalies, deafness, motor delay, and a bleeding diathesis. It is a genetically heterogeneous and relatively common syndrome, with an estimated incidence of 1 in 1000-2500 live births.Defects in RAF1 are the cause of LEOPARD syndrome type 2 (LEOPARD2) [MIM:611554]. LEOPARD syndrome is an autosomal dominant disorder allelic with Noonan syndrome. The acronym LEOPARD stands for lentigines, electrocardiographic conduction abnormalities, ocular hypertelorism, pulmonic stenosis, abnormalities of genitalia, retardation of growth, and deafness.