Second-quarter results included an adjusted gross margin ratio of 63.3 percent, an increase of 310 basis points over 2011, driven by improved efficiencies across a number of operating divisions, favorable product mix and the effect of foreign exchange. The gross margin ratio under GAAP was 62.9 percent.

Abbott is confirming its ongoing earnings-per-share guidance for 2012 of $5.00 to $5.10, reflecting another year of expected strong performance.Including specified items, projected earnings per share under GAAP would be $4.29 to $4.39 for the full-year 2012.

"Abbott continues to deliver strong results as we remain on track to separate into two leading health care companies," said Miles D. White, chairman and chief executive officer, Abbott. "During the second quarter, we launched and advanced numerous projects in our promising, broad-based pipeline and achieved key milestones in the separation process."

The following is a summary of second-quarter 2012 sales by major business category.

% Change vs. 2Q11

Sales ($ in millions)

Int'l

Total

U.S.

Int'l

Total

U.S.

Operational

Reported

Operational

Reported

Total Sales

4,178

5,629

9,807

6.1

7.0

(0.9)

6.7

2.0

Proprietary Pharmaceuticals

2,485

1,895

4,380

7.9

10.9

1.2

9.3

4.9

Nutritionals

741

843

1,584

13.1

4.5

1.0

8.3

6.3

Established Pharmaceuticals

--

1,246

1,246

n/a

3.8

(6.0)

3.8

(6.0)

Core Laboratory Diagnostics

175

709

884

15.3

7.2

0.7

8.6

3.3

Molecular Diagnostics

48

58

106

7.3

4.1

(3.8)

5.5

1.0

Point of Care Diagnostics

70

18

88

16.9

4.7

1.3

14.3

13.5

Vascular(a)

307

459

766

(22.2)a

11.1

4.3

(4.7)a

(8.3)a

Diabetes Care

144

186

330

8.6

(0.3)

(7.7)

3.3

(1.2)

Medical Optics

103

180

283

1.0

1.0

(3.9)

1.0

(2.1)

Other Sales

105

35

140

10.9

9.8

2.4

10.6

8.6

The following is a summary of six-month 2012 sales by major business category.

% Change vs. 1H11

Sales ($ in millions)

Int'l

Total

U.S.

Int'l

Total

U.S.

Operational

Reported

Operational

Reported

Total Sales

7,901

11,363

19,264

6.0

6.5

1.4

6.3

3.3

Proprietary Pharmaceuticals

4,538

3,914

8,452

7.3

10.6

4.5

8.9

6.0

Nutritionals

1,448

1,702

3,150

12.0

7.1

5.0

9.3

8.1

Established Pharmaceuticals

--

2,503

2,503

n/a

2.8

(3.9)

2.8

(3.9)

Core Laboratory Diagnostics

349

1,388

1,737

14.1

6.1

1.9

7.6

4.1

Molecular Diagnostics

95

116

211

5.2

7.6

1.9

6.6

3.4

Point of Care Diagnostics

134

38

172

16.8

15.9

14.3

16.7

16.3

Vascular(b)

649

920

1,569

(17.2)b

6.5

2.7

(4.6)b

(6.6)b

Diabetes Care

283

365

648

8.0

(3.6)

(8.2)

1.0

(1.8)

Medical Optics

203

352

555

1.3

1.6

(1.3)

1.4

(0.4)

Other Sales

202

65

267

14.1

(4.3)

(8.5)

8.8

7.6

Notes:

1)See "Consolidated Statement of Earnings" for more information.

2) "Operational" growth reflects percentage change over the prior year excluding the impact of exchange rates.

The following is a summary of second-quarter 2012 sales for select products.

% Change vs. 2Q11

Sales ($ in millions)

Int'l

Total

U.S.

Int'l

Total

U.S.

Operational

Reported

Operational

Reported

HUMIRA

1,056

1,270

2,326

27.9

19.5

8.4

23.0

16.5

TRILIPIX/TriCor (fenofibrate)

311

77

388

(5.2)

(2.3)

(12.2)

(4.5)

(6.6)

AndroGel

276

8

284

26.1

(5.7)

(10.2)

24.9

24.7

Kaletra

70

205

275

(12.5)

(13.4)

(20.1)

(13.2)

(18.3)

Lupron

140

60

200

3.9

(7.0)

(14.1)

0.2

(2.2)

Niaspan

211

--

211

(14.7)

n/a

n/a

(14.7)

(14.7)

Synthroid

122

27

149

(13.0)

19.8

6.5

(8.0)

(10.0)

Creon

88

74

162

12.1

16.9

4.8

14.4

8.7

Pediatric Nutritionals

374

489

863

25.3

4.5

1.8

12.5

10.8

Adult Nutritionals

362

354

716

3.0

4.3

(0.3)

3.7

1.4

Xience Drug-Eluting Stents

140

260

400

(2.6)

10.4

4.7

5.6

2.0

Other Coronary Products(c)

49

98

147

(5.6)

(0.6)

(7.3)

(2.3)

(6.8)

Endovascular(d)

60

55

115

(4.6)

9.7

0.8

2.0

(2.1)

The following is a summary of six-month 2012 sales for select products.

% Change vs. 1H11

Sales ($ in millions)

Int'l

Total

U.S.

Int'l

Total

U.S.

Operational

Reported

Operational

Reported

HUMIRA

1,828

2,431

4,259

25.6

18.5

11.1

21.3

16.9

TRILIPIX/TriCor (fenofibrate)

565

152

717

(8.4)

(2.1)

(8.9)

(7.1)

(8.5)

AndroGel

508

16

524

24.9

9.8

6.1

24.3

24.2

Kaletra

125

371

496

(13.6)

(10.6)

(15.8)

(11.3)

(15.2)

Lupron

282

118

400

10.6

(7.7)

(12.3)

4.2

2.6

Niaspan

402

--

402

(15.0)

n/a

n/a

(15.0)

(15.0)

Synthroid

252

52

304

(2.3)

13.5

4.5

0.3

(1.2)

Creon

156

152

308

9.2

17.3

9.4

13.2

9.3

Pediatric Nutritionals

731

992

1,723

20.2

8.6

7.1

13.2

12.3

Adult Nutritionals

710

710

1,420

5.0

5.1

2.2

5.1

3.6

Xience Drug-Eluting Stents

290

514

804

7.6

5.6

2.6

6.2

4.3

Other Coronary Products(c)

101

201

302

(1.9)

2.2

(2.0)

0.8

(2.0)

Endovascular(d)

122

106

228

(0.2)

8.6

3.0

3.8

1.2

Notes:

1)See "Consolidated Statement of Earnings" for more information.

2) "Operational" growth reflects percentage change over the prior year excluding the impact of exchange rates.

(c)

Includes guide wires, balloon catheters and other coronary products.

(d)

Includes vessel closure, carotid stents and other peripheral products.

n/a = Not applicable

Business Highlights

Received Approval for Next-Generation XIENCE PRIME Drug Eluting Stent in Japan
Announced approval in Japan for the next-generation XIENCE PRIME™ drug eluting stent for the treatment of coronary artery disease. XIENCE PRIME features an enhanced delivery system designed for greater flexibility, ideal radial strength, excellent longitudinal strength and more accurate placement.

Received Positive Opinion for HUMIRA in Axial Spondyloarthritis
Received Positive Opinion in Europe for HUMIRA® in patients with non-radiographic axial spondyloarthritis (axSpA). Also presented new data including Phase 3 results in axSpA, Phase 3 results in peripheral spondyloarthritis, and 10-year data in patients with long-standing rheumatoid arthritis.

Announced Opening of First Nutrition R&D Center in India
Established a nutrition R&D center in India in collaboration with Syngene, India's leading contract research organization. The center will focus on the development of science-based, affordable nutrition products and enable the expansion of Abbott's nutrition product portfolio in India.

Acquired Investigational Compound for Prevention of Acute Kidney Injury
Enhanced Abbott's pipeline in renal care with the acquisition of AP214 from Action Pharma A/S. AP214 is in development to prevent acute kidney injury associated with major cardiac surgery in patients at increased risk and has further potential in adjacent indications. AP214 is now known as ABT-719.

Launched Three New Medical Optics Technologies
Received U.S. approval for iFS Advanced Femtosecond Laser in cataract surgery and Healon EndoCoat OVD for use as a surgical aid in cataract extraction and intraocular lens implantation. Additionally, Abbott launched in Europe and Japan the iDesign Advanced WaveScan Studio aberrometer for mapping and analyzing corneal aberrations in the eye.

Initiated Phase 3 Study of Elagolix in Patients with Endometriosis
Announced the initiation of a pivotal Phase 3 clinical trial designed to evaluate the safety and efficacy of elagolix in female patients with endometriosis. Elagolix is an oral gonadotropin-releasing hormone (GnRH) antagonist, and is also being studied for the treatment of uterine fibroids.

Received XIENCE Indication in Europe for Three-Month Dual Anti-Platelet Therapy
Announced that XIENCE PRIME and XIENCE V®have received CE Mark in Europe for the use of dual anti-platelet therapy (DAPT) for at least three months after stent implantation in patients with coronary artery disease. This is the shortest duration of DAPT for any major drug eluting stent in Europe.

Introduced New Nutritional Products in the United States
Announced the launch of several new nutritional products, including PediaSure SideKicks® Clear for picky eaters, Ensure Clear™ fruit-flavored beverages, ZonePerfect Perfectly Simple™ limited-ingredient nutrition bars, and a new line of EAS® performance nutrition products for athletes.

Presented Strong Phase 2 Results from Abbott's Advancing Hepatitis C Program
Presented clinical trial results from two interferon-free, Phase 2 studies for the treatment of hepatitis C, PILOT and CO-PILOT. Additional data from Abbott's advancing hepatitis C program will be presented later this year at the American Association for the Study of Liver Diseases (AASLD) meeting.

Introduced New Laboratory Solutions and Diagnostic Assays
Launched key laboratory solutions, including OneLab, a novel, integrated Web-based software platform to help customers manage laboratory information, as well as important diagnostic tests in the areas of metabolics and infectious disease.

Abbott confirms ongoing earnings-per-share outlook for 2012

Abbott is confirming its ongoing earnings-per-share guidance for the full-year 2012 of $5.00 to $5.10, reflecting another year of expected strong performance.

Abbott forecasts specified items for the full-year 2012 of approximately $0.71 per share, primarily associated with in-process R&D, separation costs, acquisition integration and cost-reduction initiatives. Including these specified items, projected earnings per share under Generally Accepted Accounting Principles (GAAP) would be $4.29 to $4.39 for the full-year 2012. Our full-year forecast of specified items has increased from our previous guidance as it now includes expected 2012 one-time separation costs related to the planned separation of Abbott into two companies. The forecast of specified items does not include bond refinancing costs related to the planned separation, which will be quantified at a later date.

Abbott declares 354th quarterly dividend

On June 8, 2012, the board of directors of Abbott declared the company's quarterly common dividend of 51 cents per share. The cash dividend is payable Aug. 15, 2012, to shareholders of record at the close of business on July 13, 2012. This marks the 354th consecutive dividend paid by Abbott since 1924. Abbott is a member of the S&P 500 Dividend Aristocrats Index, which tracks companies that have annually increased their dividends for 25 consecutive years.

About Abbott

Abbott is a global, broad-based health care company devoted to the discovery, development, manufacture and marketing of pharmaceuticals and medical products, including nutritionals, devices and diagnostics. The company employs approximately 91,000 people and markets its products in more than 130 countries.

Abbott's news releases and other information are available on the company's Web site at www.abbott.com. Abbott will webcast its live second-quarter earnings conference call through its Investor Relations Web site at www.abbottinvestor.com at 8 a.m. Central time today. An archived edition of the call will be available after 11 a.m. Central time.

—Private Securities Litigation Reform Act of 1995 —

A Caution Concerning Forward-Looking Statements

Some statements in this news release may be forward-looking statements for purposes of the Private Securities Litigation Reform Act of 1995, including the planned separation of the research-based pharmaceutical company from the diversified medical products company and the expected financial results of the two companies after the separation. Abbott cautions that these forward-looking statements are subject to risks and uncertainties that may cause actual results to differ materially from those indicated in the forward-looking statements. Economic, competitive, governmental, technological and other factors that may affect Abbott's operations are discussed in Item 1A, "Risk Factors," to our Annual Report on Securities and Exchange Commission Form 10-K for the year ended Dec. 31, 2011, and are incorporated by reference. Abbott undertakes no obligation to release publicly any revisions to forward-looking statements as a result of subsequent events or developments.

Abbott Laboratories and Subsidiaries

Consolidated Statement of Earnings

Second Quarter Ended June 30, 2012 and 2011

(in millions, except per share data)

(unaudited)

2012

2011

% Change

Net Sales

$ 9,807

$ 9,616

2.0

Cost of products sold

3,637

3,870

(6.0)

Research and development

1,011

1,038

(2.6)

Acquired in-process and collaborations research and development

110

173

n/m

Selling, general and administrative

2,945

2,762

6.6

Total Operating Cost and Expenses

7,703

7,843

(1.8)

Operating earnings

2,104

1,773

18.7

Net interest expense

107

115

(7.4)

Net foreign exchange (gain) loss

(14)

(11)

n/m

Other (income) expense, net

8

(6)

n/m

Earnings before taxes

2,003

1,675

19.6

Taxes on earnings

278

(268)

n/m

1)

Net Earnings

$ 1,725

$ 1,943

(11.2)

Net Earnings Excluding Specified Items, as described below

$ 1,966

$ 1,768

11.2

2)

Diluted Earnings per Common Share

$ 1.08

$ 1.23

(12.2)

Diluted Earnings Per Common Share, Excluding Specified Items,

as described below

$ 1.23

$ 1.12

9.8

2)

Average Number of Common Shares Outstanding Plus Dilutive

Common Stock Options and Awards

1,589

1,566

1)

2011 Taxes on earnings includes a favorable adjustment to tax expense of $519 million, or $0.33 per share, as a result of the resolution of various prior years' international and U.S. tax positions. This favorable item is classified as a specified item and excluded from ongoing results, as discussed below.

2)

2012 Net Earnings Excluding Specified Items excludes after-tax charges of $64 million, or $0.04 per share, related to expenses associated with the separation transaction, $71 million, or $0.05 per share, for acquired in-process research and development related to the Action Pharma asset acquisition, and $106 million, or $0.06 per share, related primarily to restructuring and integration charges.

2011 Net Earnings Excluding Specified Items excludes after-tax charges of $60 million, or $0.04 per share, associated with the acquisition of Solvay Pharmaceuticals, $35 million, or $0.02 per share, for cost reduction initiatives and other, $76 million, or $0.05 per share, for the impairment of an R&D intangible asset, and $173 million, or $0.11 per share, relating to acquired in-process research and development related to the Reata and Biotest collaborations. These items were offset by a favorable adjustment from the resolution of prior years' international and U.S. tax positions for $519 million, or $0.33 per share.

NOTE: See attached questions and answers section for further explanation of Consolidated Statement of Earnings line items.

n/m = Percent change is not meaningful.

Abbott Laboratories and Subsidiaries

Consolidated Statement of Earnings

First Half Ended June 30, 2012 and 2011

(in millions, except per share data)

(unaudited)

2012

2011

% Change

Net Sales

$ 19,264

$ 18,657

3.3

Cost of products sold

7,362

7,729

(4.8)

Research and development

2,017

1,968

2.5

Acquired in-process and collaborations research and development

260

273

n/m

Selling, general and administrative

5,945

5,613

5.9

Total Operating Cost and Expenses

15,584

15,583

--

Operating earnings

3,680

3,074

19.7

Net interest expense

216

239

(9.6)

Net foreign exchange (gain) loss

11

(43)

n/m

Other (income) expense, net

(63)

135

n/m

1)

Earnings before taxes

3,516

2,743

28.2

Taxes on earnings

549

(63)

n/m

2)

Net Earnings

$ 2,967

$ 2,806

5.7

Net Earnings Excluding Specified Items, as described below

$ 3,614

$ 3,186

13.4

3)

Diluted Earnings per Common Share

$ 1.85

$ 1.79

3.9

Diluted Earnings Per Common Share, Excluding Specified Items,

as described below

$ 2.26

$ 2.03

11.8

3)

Average Number of Common Shares Outstanding Plus Dilutive

Common Stock Options and Awards

1,589

1,562

1)

Other (income) expense, net for 2011 includes a charge of $137 million for the impact of Abbott's change to a calendar year end for the international operations that were previously reported on a November 30 year-end. This is treated as a specified item as noted below.

2)

2011 Taxes on earnings includes a favorable adjustment to tax expense of $519 million, or $0.33 per share, as a result of the resolution of various prior years' international and U.S. tax positions. This favorable item is classified as a specified item and excluded from ongoing results, as discussed below.

3)

2012 Net Earnings Excluding Specified Items excludes after-tax charges of $98 million, or $0.06 per share, related to expenses associated with the separation transaction, $222 million, or $0.14 per share, for acquired in-process research and development related to the Galapagos collaboration and the Action Pharma asset acquisition, $50 million, or $0.03 per share, for a milestone payment related to the Reata collaboration, $111 million, or $0.07 per share for litigation and $166 million, or $0.11 per share, related primarily to restructuring and integration charges.

2011 Net Earnings Excluding Specified Items excludes after-tax charges of $142 million, or $0.09 per share, associated with the acquisition of Solvay Pharmaceuticals, $107 million, or $0.07 per share, for restructuring in the pharmaceutical business, $88 million, or $0.05 per share, for previously announced cost reduction initiatives and other, $137 million, or $0.09 per share, for the 2009 and 2010 impact of the change to a calendar year end for international operations, $273 million, or $0.17 per share, relating to acquired in-process research and development related to the Reata and Biotest collaborations, $76 million, or $0.05 per share, for the impairment of an R&D intangible asset, and $76 million, or $0.05 per share, for litigation. These items were offset by a favorable adjustment from the resolution of prior years' international and U.S. tax positions for $519 million, or $0.33 per share.

Worldwide Nutritionals sales increased 8.3 percent in the quarter, excluding an unfavorable 2.0 percent effect of foreign exchange. U.S. Nutritionals increased 13.1 percent, with U.S. Pediatric Nutritionals sales growth of 25.3 percent on continued share gains of our infant formula, Similac®, and continued double-digit growth of PediaSure®. U.S. Adult Nutritionals grew 3.0 percent, driven by strong growth of Ensure® and Glucerna®. Several new pediatric and adult nutritional products were launched in the second quarter. International Nutritionals increased 4.5 percent, excluding an unfavorable 3.5 percent effect of foreign exchange, driven by continued growth of both the pediatric and adult segments, partially offset by the transition to a direct distribution model in certain markets.

Global sales of Core Laboratory Diagnostics increased 8.6 percent, excluding an unfavorable 5.3 percent effect of foreign exchange, driven by 15.3 percent growth in the U.S. due to continued growth of ARCHITECT and PRISM, and 7.2 percent international growth, excluding an unfavorable 6.5 percent effect of foreign exchange. Point of Care Diagnostics also drove global Diagnostics sales growth in the quarter.

Q2) What is the update on Abbott's planned separation into two leading health care companies?

A2) In October 2011, Abbott announced plans to separate into two publicly traded companies, one in diversified medical products and the other in research-based pharmaceuticals. The diversified medical products company will consist of Abbott's branded generic pharmaceuticals, devices, diagnostics and nutritionals businesses, and will retain the Abbott name. The research-based pharmaceutical company, named AbbVie, will include Abbott's current portfolio of proprietary pharmaceuticals and biologics.

The transaction is intended to take the form of a tax-free distribution to Abbott shareholders of a new publicly traded stock for the new pharmaceutical company. The stock distribution ratio will be determined at a future date. It is expected that the two companies will each pay a dividend that, when combined, will at least equal the current Abbott dividend at the time of separation.

In June, Abbott filed the initial Form 10 for AbbVie, which provided historical results for AbbVie on a GAAP basis for the past three years, and for the first quarters of 2012 and 2011. These historical results included an allocation of certain costs, previously held at the corporate level, to the business. In addition, senior management assignments for AbbVie were identified. We expect to file amendments to the Form 10 as more information becomes available.

We continue to expect the separation to be completed at the end of this year.

Q3) What was the gross margin ratio in the quarter?

A3) The gross margin ratio before and after specified items is shown below (dollars in millions):

2Q12

Cost of

Products

Sold

Gross

Margin

Gross

Margin

%

As reported (GAAP)

$3,637

$6,170

62.9%

Adjusted for specified items:

Restructuring/integration/other

($42)

$42

0.4%

As adjusted

$3,595

$6,212

63.3%

The adjusted gross margin ratio was 63.3 percent in the second quarter, an increase of 310 basis points from the prior year quarter, driven by improved efficiencies across a number of operating divisions, favorable product mix and the effect of foreign exchange.

Q4) What drove ongoing SG&A and R&D investment?

A4) Both ongoing SG&A and R&D investment reflect Abbott's continued investment in programs to drive future growth. Ongoing R&D expense as a percentage of sales was 9.8 percent, or 10.3 percent on a GAAP basis, reflecting continued investment in Abbott's pipeline, including programs in vascular devices, diagnostics, nutritionals, immunology, neuroscience, chronic kidney disease and hepatitis C.

Q5) What was the tax rate?

A5) The ongoing tax rate this quarter was 15.0 percent, in line with expectations.

2Q12

Pre-Tax

Taxes on

Tax

Income

Earnings

Rate

As reported (GAAP)

$2,003

$278

13.9%

Specified items

$309

$68

22.0%

Excluding specified items

$2,312

$346

15.0%

Q6) How did specified items affect reported results?

A6) Specified items impacted second-quarter results as follows:

2Q12

(dollars in millions, except earnings-per-share)

Earnings

Pre-tax

After-tax

EPS

As reported (GAAP)

$2,003

$1,725

$1.08

Adjusted for specified items:

Acquired in-process research and development

$110

$71

$0.05

Separation costs

$78

$64

$0.04

Restructuring/integration/other

$121

$106

$0.06

As adjusted

$2,312

$1,966

$1.23

Acquired in-process research and development is related to the acquisition of AP214 from Action Pharma A/S. Separation costs are expenses related to the planned separation of Abbott into two leading health care companies. Restructuring/integration/other is associated with previously announced restructuring actions and acquisition-related integration costs.

The impact of specified items by Consolidated Statement of Earnings line item is as follows (dollars in millions):

2Q12

Cost of Products

Sold

R&D

Acquired

in-process R&D

SG&A

Other (Income)/

Expense

As reported (GAAP)

$3,637

$1,011

$110

$2,945

$8

Adjusted for specified items:

Acquired in-process research and development

--

--

($110)

--

--

Separation costs

($1)

--

--

($77)

--

Restructuring/integration/other

($41)

($46)

--

($17)

($17)

As adjusted

$3,595

$965

--

$2,851

($9)

Q7) What are the key areas of focus in Abbott's pipeline?

A7) In the first half of 2012, we made significant progress in advancing both our pharmaceutical pipeline, which currently includes more than 20 compounds or new indications in Phase 2 or Phase 3 development, as well as our diversified medical products pipeline. Following are highlights:

Hepatitis C

Abbott's antiviral program is focused on developing treatments for hepatitis C (HCV), a disease that affects more than 170 million people worldwide, with approximately 3 to 4 million people newly infected each year. Abbott's broad-based HCV program includes three mechanisms of action in Phase 2b clinical trials, including protease, polymerase and NS5A inhibitors. Abbott is evaluating combinations of these compounds, both with and without the current standard of care, a strategy that has the potential to markedly transform current treatment practices by shortening therapy duration, improving tolerability and increasing cure rates.

Earlier this year, we released positive Phase 2 results from two interferon-free studies for the treatment of HCV. In the study known as CO-PILOT, ABT-450/r, plus ABT-333 and ribavirin administered for 12 weeks showed sustained virological response at 12 weeks post treatment (SVR12) in 93 percent and 95 percent of treatment-naive genotype 1 (GT1) patients. In a separate study, known as PILOT, 91 percent of GT1 infected, treatment-naive patients taking ABT-450/r and ABT-072 combined with ribavirin administered for 12 weeks, achieved sustained viral response at 24 weeks (SVR24). Larger Phase 2 clinical trials are ongoing, and we expect to present additional data later this year.

Chronic Kidney Disease

In May, Abbott enhanced its pipeline in renal care with the acquisition of AP214, an investigational compound in development to prevent acute kidney injury (AKI) associated with major cardiac surgery in patients at increased risk. The compound also has further potential in adjacent indications. AP214 is a hormone analogue that targets both systemic inflammation and cellular death (apoptosis) caused by hypoxia (lack of blood flow) that can occur during surgery. In September 2011, Action Pharma announced positive Phase 2b top-line results evaluating the efficacy, safety and tolerability of AP214. Abbott plans to conduct another Phase 2b study, which is expected to begin later this year.

Bardoxolone, an investigational treatment for chronic kidney disease (CKD), is a first-in-class antioxidant inflammation modulator that activates Nrf2, a pathway involved in the progression of CKD. A global Phase 3 trial is currently underway. Abbott's agreement with Reata Pharmaceuticals includes international rights to bardoxolone, excluding the U.S. and certain Asian markets.

Also in development for the treatment of CKD is atrasentan, a compound discovered by Abbott scientists. A Phase 2b study in patients with diabetic kidney disease is ongoing with results expected later this year.

Immunology

Abbott's scientific experience with HUMIRA serves as a strong foundation for its continuing research in immunology. We are developing several additional indications for HUMIRA and have a number of next-generation programs underway to address various immune-mediated conditions, including five programs in development for rheumatoid arthritis (RA) alone.

Abbott recently received approval in Europe for HUMIRA for the treatment of ulcerative colitis, and in June, we received Positive Opinion in Europe for HUMIRA in patients with non-radiographic axial spondyloarthritis. We also initiated two Phase 3 clinical trials to evaluate HUMIRA in patients with hidradenitis suppurativa, a dermatologic condition for which there are currently no approved treatments.

Earlier this year, we announced a global collaboration to develop and commercialize an oral, next-generation JAK1 inhibitor in Phase 2 development with the potential to treat RA and other autoimmune diseases. We are also evaluating a number of other oral programs including an internal JAK1 candidate and a SYK inhibitor. Additionally, in late 2011 we announced plans to jointly develop and commercialize Reata's portfolio of second-generation oral antioxidant inflammation modulators, with potential in RA and other conditions.

Abbott's proprietary DVD-Ig technology represents an innovative approach that can target multiple disease-causing antigens with a single biologic agent. This technology could lead to next-generation biologic treatments for complex conditions such as cancer or RA, where multiple pathways are involved in the disease. In 2011, we advanced two DVD-Ig molecules into Phase 1 clinical trials.

Abbott's anti-CD4 biologic, BT-061, in development with a partner company, is currently in Phase 2 clinical trials for RA and psoriasis.

Oncology

Abbott's oncology pipeline includes therapies that represent promising, unique scientific approaches to treating cancer. Abbott is focused on the development of targeted treatments that inhibit tumor growth and improve response to common cancer therapies.

Elotuzumab, an anti-CD37 antibody, is currently in Phase 3 development with a partner company for multiple myeloma. Abbott is evaluating a number of promising mechanisms, including work on EGFR, Bcl2, PARP, aurora kinase and cMET, among others.

Neuroscience / Pain

Abbott is conducting innovative research in neuroscience, where it has developed compounds that target receptors in the brain that help regulate mood, memory and other neurological functions. Abbott has a number of compounds in human studies for conditions such as schizophrenia, pain, Alzheimer's disease, Parkinson's disease and multiple sclerosis (MS).

Abbott is partnering on the development of a novel, next-generation antibody, daclizumab, which is currently in Phase 3 clinical trials for MS.

Additionally, Abbott recently announced positive results from a Phase 3 trial evaluating levodopa-carbidopa intestinal gel (LCIG) for advanced Parkinson's disease. We expect to submit a U.S. regulatory application for LCIG this year.

Women's Health

Elagolix, a novel, first-in-class oral gonadotropin-releasing hormone (GnRH), is in development for the treatment of endometriosis-related pain and fibroids. Abbott and its partner recently initiated a Phase 3 study in endometriosis and a Phase 2 study in uterine fibroids is underway.

Vision Care

Abbott expects numerous new products and technology advancements over the next five years from its cataract, refractive and corneal business units. In its market-leading LASIK business, Abbott is expanding its proprietary laser platform into new vision correction applications, including cataract surgery. Abbott also continues to expand its portfolio of cataract technologies which includes intraocular lenses (IOLs), phacoemulsification systems and viscoelastics.

Abbott recently received U.S. FDA clearance to use Abbott's iFS Advanced Femtosecond Laser in cataract surgery, giving surgeons the ability to make precise, bladeless incisions during surgery and customize for each individual patient. Abbott also expanded its Healon® family of ophthalmic viscosurgical devices (OVDs) with the FDA approval of Healon EndoCoat OVD, a device intended for use as a surgical aid in cataract extraction and IOL implantation. Additionally, Abbott launched in Europe and Japan the iDesign Advanced WaveScan Studio aberrometer, a next-generation diagnostic tool for mapping and analyzing corneal aberrations in the eye.

Vascular Devices

Abbott has one of the industry's most robust vascular pipelines and is working on well-staged incremental advances and truly game-changing technologies that have the ability to restate the market.

Drug Eluting Stents (DES) – Abbott has several next-generation DES platforms on the market and in development. Earlier this year, XIENCE PRIME received approval in Japan, and is now available in all of the major markets worldwide. Also in development is XIENCE Xpedition®, our next-generation DES that offers a new catheter for enhanced deliverability, as well as a broader size matrix. We expect Xpedition to launch in Europe this year and in the United States in 2013.

Core Coronary products – Abbott is continuing to expand its position in the more-than-$2 billion core coronary market. Abbott's next-generation balloon dilatation catheter, TREK®, is available in the United States, Europe and Japan, and we plan to introduce additional balloon catheters and next-generation guide wires over the next few years.

Bioresorbable Vascular Scaffold (BVS) – Abbott has the most advanced BVS clinical program in the industry. Absorb™, the world's first drug-eluting BVS for the treatment of coronary artery disease, restores blood flow to the heart by opening a clogged vessel and providing support to the vessel until the device dissolves, leaving patients with a treated vessel free of a permanent metallic cage. Absorb is authorized for sale in Europe and is an investigational device in a number of countries around the world. We recently presented two-year data demonstrating impressive efficacy and safety results for Absorb for the treatment of coronary and peripheral artery disease.

MitraClip – MitraClip® is a minimally invasive device for the treatment of select patients with mitral regurgitation (MR), the most common valve disease in the world. Significant MR affects more than 8 million people in the United States and Europe, and is four times more prevalent than aortic stenosis. Abbott's MitraClip system is on the market in Europe and a number of other countries and is currently under U.S. FDA review.

Endovascular products – Abbott's endovascular business is led by recent launches of key products including the Armada peripheral balloon line and the RX Herculink Elite® Renal Stent System, and R&D investments in peripheral artery disease and vessel closure. Earlier this year, we announced U.S. FDA approval of the Absolute Pro® Vascular Self-Expanding Stent System for the treatment of iliac artery disease, a form of peripheral artery disease that affects the lower extremities.

Molecular Diagnostics

Earlier this year, Abbott obtained CE Mark in Europe for its rapid, high-throughput PLEX-ID instrument, along with three assays for use on the system. PLEX-ID addresses a significant unmet need for rapid detection and identification of a broad range of microbes that cause infections in patients. Abbott expects to launch more than 15 new molecular diagnostic products over the next few years, including several novel oncology, infectious disease and companion diagnostic assays.

Core Laboratory Diagnostics

Abbott is focusing on near-term launches of important automation and informatics solutions to help improve efficiencies in the laboratory. These important innovations will play a critical role in reducing the time it takes for a test result to be delivered to the physician to aid in patient diagnosis. Earlier this month, Abbott announced CE Marking for the ARCHITECT HbA1c Assay, which detects glycated hemoglobin, used primarily to monitor long-term diabetes control. Additionally, Abbott expects to launch assays in the areas of cardiac care, fertility, metabolics and infectious disease, which will broaden and differentiate its industry-leading menu.

Future growth for the Core Laboratory Diagnostics business will be driven by its next-generation blood screening, hematology, and immunochemistry analyzers, as well as advanced automation and informatics solutions to provide high-quality results and information, while enhancing laboratory productivity and reducing costs.

Nutrition

Abbott is focused on improving six areas through nutrition: immunity, cognition, lean body mass, inflammation, metabolism and tolerance. In the first half of 2012, Abbott launched more than 40 new innovations in key markets around the world, including Similac Stage 1 in India, Similac Total Comfort in Brazil and Hong Kong, Similac Mom in Taiwan, Glucerna Triple Care in Vietnam, and Ensure Clear, PediaSure SideKicks Clear and ZonePerfect Perfectly Simple in the United States. We expect to continue to launch a number of new products and formulations this year and have more than 30 clinical studies underway to demonstrate proven outcomes with our nutrition innovation.

Established Pharmaceuticals

Abbott's large and growing portfolio of more than 500 established pharmaceuticals consists of trusted, well-known brands that have broad use throughout the world. Over the next several years, we expect to bring these medicines to broader patient populations through registrations across multiple geographies, as well as launches of improved formulations to enhance efficacy and improve convenience. We continue to expand our presence and launch new brands, packaging enhancements and formulations.

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