Summary: The JetStream Navitus (JS) atherectomy device is a rotational cutter with aspiration capability designed to treat infrainguinal arterial obstructive disease. JS XC can be operated with blades down (BD) (2.1 or 2.4 mm perimeter) or blades up (BU) (3.0 or 3.4 mm perimeter) to treat femoropopliteal obstructive disease. It is unclear whether an orbital effect is present while operating the JS leading to a larger minimal luminal area (MLA) than predicted based on device size. Also, the minimum MLA and plaque surface area (PSA) needed in a typical size femoral artery (5-6 mm) for the device to be effective has not been defined. Using an in-stent restenosis (ISR) porcine model and intravascular ultrasound (IVUS) assessment of lesions these questions were addressed.