The ENIGMA – Addiction working group analyzes data relevant to addiction phenotypes including case-control comparisons across a variety of substances. Going beyond this, the group will also examine the influence of comorbidities, gender and stages of disorder.

The ENIGMA meta-analytic approach is used to aggregate data from case-control and developmental cohorts to examine the relative contribution of various genetic and brain correlates on risk for early onset substance misuse, transition to regular use, susceptibility to dependence, and individual differences in relapse vulnerability.