Paramedics were told to “f*** off” by a Black Mamba user whose life they had saved after he overdosed on the drug.

Two deaths have been linked to the synthetic high this year and emergency services are dealing with incidents related to the substance on a daily basis - but many patients are shunning their help.

The substance has been dubbed a “plague” on the city centre’s streets with a call not to give to beggars who are using money to buy the drug and similar varieties known as ‘fake weed’. Paramedic Sam Grimson revealed details on Twitter of one user who verbally abused a crew who saved his life on Friday.

He wrote: “Forty year-old-male Mamba OD unconscious. Life saving treatment given and the first thing he says is F*** off. Lovely.”

The same night Rob Moore, another paramedic with West Midlands Ambulance Service, also used Twitter to highlight the widespread use of the substance.

He wrote: “No fewer than 75 per cent of my calls tonight have involved ‘Mamba’ use – the last was unresponsive for a while before waking and walking off.”

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Collapses known as ‘Mamba attacks’ are placing a strain on the emergency services, with West Midlands Police dealing with incidents on a daily basis.

Mr Poole, speaking at a police awareness drive last month, said: “The ambulance will turn out and they refuse to go in the ambulance.”

Beggars have been filmed rolling and smoking joints laced with mamba which they say are a suppressant to cope with life on the streets.

Former user David McCaffrey filmed one incident of a man who is thought to have collapsed after a ‘mamba attack’ triggered when he smoked a joint laced with the drug. A homeless man named by friends as Damien Deenan, said to have been in his 40s, died after smoking mamba in the city centre last month.

Later another man, who has not been named, died outside Lloyds Bank’s New Street branch having reportedly also used the substance.

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A leaflet launched by West Midlands Police warns that the ingredients are “toxic and cause a zombie-like state or death”.The force hit the city centre last month to hand out the flyer as part of an awareness campaign.

Varieties of former legal highs were reclassified as Class B drugs earlier this year. Before the change, only the production and supply of the drugs was illegal, but possession was not.