This new study and another by Bender et al. {1} find that deletions in mitochondrial DNA (mtDNA) accumulate with aging, and are found at very high levels in dopamine-producing neurons within the substantia nigra.

In the study by Bender et al. {1}, the authors examined mtDNA deletions in individual neurons of substantia nigra at various ages, and compared the mutational loads in the COX-positive and COX-deficient neurons.

The authors...

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