Set in Springfield, the average American town, the show focuses on the antics and everyday adventures of the Simpson family; Homer, Marge, Bart, Lisa and Maggie, as well as a virtual cast of thousands. Since the beginning, the series has been a pop culture icon, attracting hundreds of celebrities to guest star. The show has also made name for itself in its fearless satirical take on politics, media and American life in general.

When Bart commits an extremely destructive prank, he is given Focusyn, a pill to help him concentrate in school. At first the results are impressive, and then Bart starts believing in a conspiracy involving spy satellites and major league baseball.

With Lisa's help, Homer uses his vast knowledge of food to become the town's leading restaurant critic. But when he gets petty and vindictive in his criticisms, all the other chefs in town try to kill him.

In "I Know What You Diddily-Iddly-Did" the SImpsons fear they have killed Ned Flanders. "Desperately Xeeking Xena" satirizes superheroes of yore with "Stretch Dude" Bart and "Clobber Girl" Lisa. And "Life's A Glitch, Then You Die" depicts the upcoming horror of Y2K.

Fleeing from a duel, Homer takes his family to live on a farm. There he discovers that by mixing tomatoes, tobacco and radioactivity from the nuclear plant, he can create a dangerously delicious new substance.

Due to overuse of fertility medication, Apu and wife Manjula give birth to octuplets. Desperate for money, Apu loans the babies to an unscrupulous carny promoter, then needs Homer's help to get them back.

In this Christmas-themed episode, the students of Springfield Elementary are unwittingly used as a focus group to test new toys. The product of their labors, a cuddly doll named Funzo, is a lot more sinister than he appears.

Homer gets a bucket stuck on his head, and when it is removed the town is convinced that Bart has the powers of a faith healer. Then mobster Fat Tony tries to turn the boy's spiritual abilities into more sinister directions.

When Homer fails to give money he promised over the phone, he is forced by PBS stars to flee the country. He becomes a missionary on a small tropical island, where he introduces the natives to casino gambling.