Target

Function

E3 ubiquitin ligase. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striated muscle atrophy and hypertrophy by regulating an anti-hypertrophic PKC-mediated signaling pathway. May regulate the organization of myofibrils through TTN in muscle cells.

Tissue specificity

Muscle specific. Selectively expressed in heart and skeletal muscle. Also expressed in the iris.

Immunohistochemical analysis of paraffin-embedded Human esophagus cancer tissue labeling MURF1 using ab183094 at a 1/60 dilution, Image on the right is treated with the synthetic peptide (original magnification: ×200).