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Anti-Human CD141 (1A4)-173Yb—100 Tests

CD141, also known as thrombomodulin, is a 75 kDa, single-chain, type I membrane glycoprotein that binds to and allosterically activates thrombin. After binding to thrombin, this complex cleaves protein C and the thrombin activatable fibrinolysis inhibitor (TAFI), initiating an important anticoagulant and antifibrinolytic pathway. CD141 is expressed on macrophages, monocytes, a subpopulation of myeloid dendritic cells, vascular endothelial cells, and keratinocytes. Soluble CD141 is constitutively present in the serum at a very low level and can be up-regulated during inflammation.