Protecting Patients

Medication Interactions & Precautions:

Protecting Patients

Arizona and Boston have now had legal cases protecting a patient's right to use Cannabis products. March 2019 in Arizona a lawsuit was brought against Walmart for an employee who tested positive for THC. It is currently in favor of the patient!

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Pancreatic Cancer

Cancer & Chemo Related Side Effects Treatment

Pancreatic Cancer

Summary: Cannabinol receptors have been identified in pancreatic cancer with several studies showing in vitro antiproliferative and proapoptotic effects. Their effects are predominately mediated through, CBR-1, CBR-2, and PR55 pathways. In vitro studies consistently demonstrated tumor growth-inhibiting effects with CBD, THC, and synthetic derivatives. Synergistic treatment effects have been shown in two studies with the combination of CBD/synthetic cannabinoid receptor ligands and chemotherapy in xenograft and genetically modified spontaneous pancreatic cancer models. There are no clinical studies showing treatment benefits in patients with pancreatic cancer.

If you have pancreatic CA and are treating with cannabis - a new research project with Dr. Ana Jewitt at UCLA may be linked to a cure!

Glioblastoma

Cancer & Chemo Related Side Effects Treatment

Pancreatic Cancer

This data suggests that CBD may, via modulation of EVs and PHB, act as an adjunct to enhance treatment efficacy in GBM, supporting evidence for efficacy of cannabinoids in GBM.

Cancer & Chemo Related Side Effects Treatment

Cancer & Chemo Related Side Effects Treatment

Cancer & Chemo Related Side Effects Treatment

C Diff?

Can I fly with cannabis/hemp?

Cancer & Chemo Related Side Effects Treatment

Cannabidiol improved Clostridium difficile toxin A-induced damage in Caco-2 cells, by inhibiting the apoptotic process and restoring the intestinal barrier integrity, through the involvement of the CB1 receptor.

Can I fly with cannabis/hemp?

Can I fly with cannabis/hemp?

Can I fly with cannabis/hemp?

Many of my patients ask if they can fly with Cannabis/Hemp products. As a reminder, Cannabis is still federally ILLEGAL. Airlines are governed by federal rules, so therefore, flying with cannabis products is illegal. BUT in a huge turn of events this weekend, due to the new Federal Farm Bill which allows for Hemp derived CBD, the TSA is allowing for HEMP CBD on airlines.

This article does a very nice job describing the details of the change

Anesthesia

Can I fly with cannabis/hemp?

Can I fly with cannabis/hemp?

The client should notify their doctor and/or anesthesiologist that they are taking CBD.

At the Dravet.org Conference this past weekend, one of the doctors researching mitochondrial disorders mentioned a case study of a Dravet Syndrome child on CBD who went in for routine surgery. After extreme difficulty waking her up post surgery (hours – not just a little difficulty), it was realized that the CBD acts on the same Complex 1 enzyme in the electron transport chain in the mitochondria that the anesthesia does, and thus the child was given roughly 5 times the proper amount of anesthesia. Complex 1 shuttles electrons from the bottom of the primary chain to the “top” of the secondary chain, and as the electrons “fall” down the chain, energy (ATP) is generated for the cell. If this process is interrupted, the cells are devoid of energy and cannot function. I just wanted to make sure parents whose kids are on CBD are aware of this interaction should any surgeries (planned or emergency) come up. Had there also been a mitochondrial disorder with Complex 1, this could have been even more serious than it was. Before this doctor’s presentation, I had no idea this was a potential issue. It just underscores the importance of all of the medical professionals who come into contact with our kids being aware of the alternative therapies we’re using, even if they’re not overseeing them.

They used less anesthesia and monitored his sedation level with a BIS monitor