No. 8 Ohio State Stunned; U.S.C. Nips Stanford

Michael Brewer passed for two touchdowns, and Virginia Tech’s defense stood tough at the end as the visiting Hokies upset No. 8 Ohio State, 35-21, on Saturday night.

Keyshoen Jarrett had two interceptions, and Donovan Riley returned another 63 yards for a touchdown in the final minute before a record crowd announced at 107,517 at enlarged Ohio Stadium.

Brewer led the Hokies (2-0) to a 21-7 lead at halftime. After his fumble led to the Buckeyes (1-1) pulling even on Ezekiel Elliott’s 15-yard run early in the fourth quarter, Brewer led a 65-yard march capped by his 10-yard scoring pass to Bucky Hodges with 8 minutes 44 seconds left.

The defense then stymied Ohio State quarterback J. T. Barrett.

U.S.C. 13, STANFORD 10 Andre Heidari kicked a career-long 53-yard field goal with 2:30 remaining, and J. R. Tavai forced a fumble to end host Stanford’s comeback bid as No. 14 Southern California (2-0) held off the No. 13 Cardinal, earning its first win at Stanford Stadium since 2008.

With Stanford (1-1), the defending Pacific-12 Conference champion, threatening to tie or take the lead, Tavai charged toward quarterback Kevin Hogan’s blind side to jar the ball loose. Scott Felix recovered at the Trojans’ 26 with 19 seconds to play, sealing Coach Steve Sarkisian’s first major victory at U.S.C.

Stanford’s 17-game home winning streak, the longest in the country, also ended.

NEBRASKA 31, MCNEESE ST. 24 A spectacular 58-yard touchdown by Ameer Abdullah after a short pass from Tommy Armstrong Jr. broke a tie with 20 seconds left and allowed No. 19 Nebraska (2-0) to beat visiting McNeese State (0-1), a Football Championship Subdivision team.

FLORIDA STATE 37, CITADEL 12 Florida State quarterback Jameis Winston threw for 256 yards and two touchdowns, and the top-ranked host Seminoles (2-0) cakewalked to a victory over the Citadel (0-2). F.S.U.’s 18th consecutive win set a program record.

ALABAMA 41, FLA. ATLANTIC 0 Blake Sims had 214 passing yards and Jake Coker threw for 202 to lead second-ranked Alabama (2-0) to a win over visiting Florida Atlantic (0-2) in a game cut short by lightning. It was the first time that two Crimson Tide quarterbacks had thrown for 200 yards in the same game. Alabama also amassed the second-most passing yards in program history, behind Scott Hunter’s 484 against Auburn in 1969.

CLEMSON 73, S. CAROLINA ST. 7 Cole Stoudt completed 22 of 31 passes for 302 yards, and No. 23 Clemson (1-1) had its highest point total in 33 years in a win over host South Carolina State (1-1). The 73 points were the most scored by the Tigers since an 82-24 win over Wake Forest in 1981, and it was their biggest margin since beating Presbyterian, 67-0, in 1957. OKLAHOMA 52, TULSA 7 No. 4 Oklahoma got 177 yards receiving from Sterling Shepard as it trounced host Tulsa (1-1).

Trevor Knight passed for 299 yards and two touchdowns and ran for another score for the Sooners (2-0). AUBURN 59, SAN JOSE STATE 13 Cameron Artis-Payne ran for three touchdowns, all in the first half, and No. 5 Auburn (2-0) used a dominant ground game to beat visiting San Jose State (1-1).

BAYLOR 70, N’WESTERN ST. 6 The Baylor backup quarterback Seth Russell threw for 438 yards and five touchdowns while playing only the first half, and the freshman K. D. Cannon caught three of those scores as No. 10 Baylor (2-0) overwhelmed visiting Northwestern State (0-2).

Cannon finished with six catches for 223 yards, the second most in program history, even without playing after halftime.

S. CAROLINA 33, E. CAROLINA 23 Mike Davis ran for 101 yards and two touchdowns as No. 21 South Carolina (1-1) bounced back from an embarrassing opening-week loss to Texas A&M to hold off visiting East Carolina (1-1).

The victory was Steve Spurrier’s 200th as a Southeastern Conference coach at Florida and with the Gamecocks. Only Bear Bryant, with 292, and Vince Dooley, with 201, have more.

Waters threw for 239 yards and ran for a career-high 138 yards for the Wildcats (2-0) in the Big 12 opener for both teams.

MISSOURI 49, TOLEDO 24 Maty Mauk threw for 325 yards and five touchdowns, and No. 24 Missouri (2-0) gave Coach Gary Pinkel a win against Toledo (1-1), his former program.

Pinkel is the winningest coach at both universities. MISSISSIPPI 41, VANDERBILT 3 Bo Wallace threw for 320 yards and a touchdown, and 15th-ranked Mississippi (2-0) routed Vanderbilt (0-2) in the Southeastern Conference opener for both teams.

ARIZONA ST. 58, NEW MEXICO 23 Taylor Kelly threw for two touchdowns and ran for another, and D. J. Foster rushed for a career-high 216 yards as No. 17 Arizona State (2-0) beat host New Mexico (0-2).

WISCONSIN 37, W. ILLINOIS 3 Tanner McEvoy overcame a slow start to throw for three touchdowns and run for another, and No. 18 Wisconsin (1-1) pulled away from Western Illinois (1-1) in its home opener.

U.N.C. 31, SAN DIEGO ST. 27 Tim Scott’s interception in the end zone with 14 seconds left preserved a victory for No. 21 North Carolina (2-0) over visiting San Diego State (1-1).

LOUISVILLE 66, MURRAY STATE 21 The Louisville backup quarterback Reggie Bonnafon ran for two touchdowns and passed for another, and the No. 25 Cardinals (2-0) defeated visiting Murray State (1-1).

A version of this article appears in print on , on Page SP9 of the New York edition with the headline: No. 8 Ohio State Stunned; U.S.C. Nips Stanford. Order Reprints | Today’s Paper | Subscribe