The first known use of clomipramine was
in 1975

Medical Definition of clomipramine

: a tricyclic antidepressant taken orally in the form of its hydrochloride C19H23ClN2·HCl to treat obsessive-compulsive disorderResearchers agree that clomipramine dramatically reduces the repetitious behaviors of many people with obsessive compulsive disorder.— Ron Cowen, Science News, 14 Oct. 1989 Clomipramine is marketed under the trademark Anafranil.