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High Triglycerides (Holistic)

About This Condition

Too many of the fatty compounds known as triglycerides can compromise your health. According to research or other evidence, the following self-care steps may be helpful.

Don't forget the fish

Eat more fatty fish and take a daily fish oil supplement providing 3,000 mg of the triglyceride-lowering omega-3 fatty acids EPA and DHA

Get the niacin you need

Under your doctor’s supervision, take niacin (vitamin B3) in amounts large enough to reduce triglyceride levels

Slim down

Normalize triglyceride levels by losing excess weight through a long-term program of exercise and healthier eating

Diet right

Eat less sugar and other refined carbohydrates, and limit alcohol and caffeine

Focus on fitness

Begin a regular exercise program to lower triglyceride levels

About

About This Condition

Triglycerides (TGs) are a group of fatty compounds that circulate in the bloodstream and are stored in the
fat tissue. Individuals who have elevated blood levels of TGs (known as hypertriglyceridemia) appear to be at
increased risk of developing heart disease.

People with diabetes often have elevated TG levels. Successfully
controlling diabetes will, in some cases, lead to normalization of TG levels.

Symptoms

Very high triglycerides can cause pancreatitis, an enlarged liver and spleen, and fatty deposits in the skin called xanthomas. Otherwise, high triglycerides may not cause symptoms until and unless heart disease or other diseases of blood vessels develop.

Healthy Lifestyle Tips

Exercise lowers TG levels.1 People who have diabetes, heart disease, or are over the age of 40, should talk with a doctor before beginning an exercise program.

Smoking has been linked to elevated TG levels.2 As always, it makes sense for smokers to quit.

Obesity increases TG levels.3 Maintaining ideal body weight helps protect against elevated TG levels. Many doctors encourage people who have elevated TGs and who are overweight to lose the extra weight.

Eating Right

The right diet is the key to managing many diseases and to improving general quality of life. For this condition, scientific research has found benefit in the following healthy eating tips.

Recommendation

Why

Choose good fats

Many doctors recommend a diet higher in unsaturated fats, such as olive oil, over a diet high in saturated fat to reduce triglycerides and heart disease risk. In other words, choose fish, soy, and nonfat dairy, and avoid meats and fatty dairy.

The blood level of TGs following a meal may be a more important indicator of coronary heart disease risk than the fasting level.4, 5 However, a low-fat diet (55% carbohydrates, 23% fats, 22% proteins) that succeeded in normalizing other blood lipids, including fasting TG levels, failed to normalize post-meal TG levels in a group of people with hypertriglyceridemia.6 These results suggest that dietary reduction of fasting TGs, even if the diet controls other blood lipids, may not be enough to provide optimal protection against coronary heart disease. Many doctors recommend a diet low in saturated fat (meaning avoidance of red meat and all dairy except nonfat dairy) to reduce TGs and the risk of heart disease.7

Eat more fish

Triglyceride-lowering omega-3s are found in fatty fish such as herring, mackerel, sardines, anchovies, albacore tuna, and black cod.

Some,8, 9 but not all,10 studies have found that increasing consumption of fish is associated with a lower risk of heart disease. Significant amounts of TG-lowering omega-3 fatty acids (EPA and DHA) can be found in the fish oil of salmon, herring, mackerel, sardines, anchovies, albacore tuna, and black cod. Many doctors recommend that people with elevated TGs increase their intake of these fatty fish.

Focus on fiber

Diets high in fiber have reduced triglyceride levels in some studies. Water-soluble fibers, such as those found in fruit, beans, and oats, may be particularly helpful.

Diets high in fiber have reduced TG levels in several clinical trials,11 but have had no effect in other clinical trials.12 Water-soluble fibers, such as pectin found in fruit, guar gum and other gums found in beans, and beta-glucan found in oats, may be particularly helpful in lowering triglycerides.

Don’t drink to excess

While drinking moderate amounts of alcohol does not appear to affect triglyceride, heavy drinking is believed to increase levels.

While consuming moderate amounts of alcohol does not appear to affect TG levels, heavy drinking is believed to be an important cause of hypertriglyceridemia.13 Alcoholics with elevated TG levels should deal with the disease of alcoholism first.

Limit sugar

People with elevated triglycerides should replace sugary foods and beverages with natural, unsweetened options, as refined sugar increases triglyceride levels.

Ingesting refined sugar increases TG levels, as well.14, 15 People with elevated TGs should therefore reduce their intake of sugar, sweets, and other sugar-containing foods. There is also evidence that ingesting fructose in amounts that are found in a typical Western diet can raise TG levels, although not all studies agree on that point.16 It should be noted that most studies of fructose investigated the refined form, not the fructose that occurs naturally in some fruits.

Try a low-fat, high-complex-carb diet

In one study, a low-fat diet high in unrefined carbohydrates reduced triglycerides.

Consumption of a low-fat, high-carbohydrate diet reduced TGs in one study.17 However, in another study, populations that consumed a low-fat, high-carbohydrate diet had higher TG levels, compared with populations that consumed lower amounts of carbohydrates.18 Suddenly switching to a high-carbohydrate, low-fat diet will generally increase TGs temporarily, but making the switch gradually protects against this short-term problem.19

Cut the caffeine

In a study of heavy caffeine users, changing to decaffeinated coffee and eliminating all other caffeinated products reduced triglyceride levels by 25%.

In a study of heavy caffeine users (individuals who were consuming an average of 560 mg of caffeine per day from coffee and tea), changing to decaffeinated coffee and eliminating all other caffeinated products for two weeks resulted in a statistically significant 25% reduction in TG levels.20

Supplements

Our proprietary “Star-Rating” system was developed to help you easily understand the amount of scientific support behind each supplement in relation to a specific health condition. While there is no way to predict whether a vitamin, mineral, or herb will successfully treat or prevent associated health conditions, our unique ratings tell you how well these supplements are understood by some in the medical community, and whether studies have found them to be effective for other people.

For over a decade, our team has combed through thousands of research articles published in reputable journals. To help you make educated decisions, and to better understand controversial or confusing supplements, our medical experts have digested the science into these three easy-to-follow ratings. We hope this provides you with a helpful resource to make informed decisions towards your health and well-being.

Many double-blind trials have demonstrated that fish oils (also called fish-oil concentrates) containing EPA and DHA (mentioned above) lower TG levels.21 The amount of fish oil used in much of the research was an amount that provided 3,000 mg per day of omega-3 fatty acids. To calculate how much omega-3 fatty acid is contained in a fish oil supplement, add together the amounts of EPA and DHA. For example, a typical 1,000-mg capsule of fish oil provides 180 mg of EPA and 120 mg of DHA (total omega-3 fatty acids equals 300 mg). Ten of these capsules would contain 3,000 mg of omega-3 fatty acids. Other sources of omega-3 fatty acids, such as flaxseed oil, do not lower TGs. While flaxseed oil has other benefits, it should not be used for the purpose of reducing TGs.

Cod liver oil, another source of omega-3 fatty acids, has also been found to lower TGs.22 Cod liver oil is less expensive than the fish oil concentrates discussed previously. However, cod liver oil also contains relatively large amounts of vitamin A and vitamin D; too much of either can cause side effects. In contrast, fish oil concentrates have little or none of these vitamins. Individuals wishing to use cod liver oil as a substitute for a fish-oil concentrate should consult a doctor.

Omega-3 fatty acids from fish oil and cod liver oil have been reported to affect blood in many other ways that might lower the risk of heart disease.23 However, these supplements sometimes increase LDL cholesterol—the bad form of cholesterol. A doctor can check to see if fish oil has this effect on an individual. Research shows that when 900 mg of garlic extract is added to fish oil, the combination still dramatically lowers TG levels but no longer increases LDL cholesterol.24 Therefore, it appears that taking garlic supplements may be a way to avoid the increase in LDL cholesterol sometimes associated with taking fish oil. People who take fish oil may also need to take vitamin E to prevent the oil from undergoing potentially damaging oxidation in the body.25 It is not known how much vitamin E is needed to prevent such oxidation. The amount required would presumably depend on the amount of fish oil used. In one clinical trial, 300 IU of vitamin E per day prevented oxidation damage in individuals taking 6 grams of fish oil per day.26

3 Stars

Guggul

25 mg guggulsterones three times per day

Clinical trials indicate that guggul is effective in treating high triglycerides, in one trial, serum triglycerides fell by 30.3%.

Guggul, a mixture of ketonic steroids from the gum oleoresin of Commiphora mukul, is an approved treatment of hyperlipidemia in India and has been a mainstay of Ayurvedic herbal approaches to preventing atherosclerosis. Clinical trials indicate that guggul is effective in the treatment of high TGs; in one trial, serum TGs fell by 30.3%.27

However, these results have not been confirmed by large, controlled trials. The recommended daily intake of guggul is typically based on the amount of guggulsterones in the extract. The recommended amount of guggulsterones is 25 mg three times per day. Most extracts contain 5–10% guggulsterones. Guggul’s effect on TGs should be monitored for three to four months, and guggul may be taken long term if successful in lowering TGs.

3 Stars

Pantothenic Acid

300 mg pantethine three times per day

Pantethine, a byproduct of pantothenic acid (vitamin B5), has been shown to lower triglyceride levels in several clinical trials.

Pantethine is a byproduct of pantothenic acid (vitamin B5). Several clinical trials have shown that 300 mg of pantethine taken three times per day will lower TG levels.28, 29, 30 Pantothenic acid, which is found in most B vitamins, does not have this effect.

3 Stars

Vitamin B3 (Niacin)

500 mg three times per day

The niacin form of vitamin B3 is used by some doctors to lower triglycerides, however, the quantity needed to achieve reductions may cause side effects. Ask your doctor is niacin is right for you.

The niacin form of vitamin B3 is used by doctors to lower cholesterol levels, but niacin also lowers TG levels.31 The amount of niacin needed to achieve worthwhile reductions in cholesterol and TG levels is several grams per day. Such quantities can cause side effects, including potential damage to the liver, and should not be taken without the supervision of a doctor. Some doctors recommend inositol hexaniacinate (a special form of vitamin B3) as an alternative to niacin. A typical amount recommended is 500 mg three times per day.32, 33 This form of vitamin B3 does not typically cause a skin flush and is said to be safer for the liver than niacin. However, the alleged safety advantage of inositol hexaniacinate needs to be confirmed by additional clinical trials. Moreover, it is not clear whether inositol hexaniacinate is as effective as niacin at lowering cholesterol and TG levels.

2 Stars

Astaxanthin

4 to 12 mg daily

Astaxanthin has antioxidant and other properties that might support proper regulation of blood lipids.

Astaxanthin is a member of the carotenoid family that has antioxidant and other properties that might support proper regulation of blood lipids.34, 35 One double-blind trial in normal weight people with high blood triglycerides found astaxanthin, taken in amounts of either 12 mg or 18 mg per day, lowered blood triglycerides.36 However, in another double-blind trial in overweight people with normal triglycerides, 20 mg per day of astaxanthin had no significant effect on blood triglycerides.37

2 Stars

Asteraceae

15 to 20 drops of tincture twice per day

Achillea wilhelmsii, an herb used in traditional Persian medicine, has been shown to significantly lower triglycerides in one trial.

In a double-blind trial, people with moderately high triglycerides took a tincture of Achillea wilhelmsii, an herb used in traditional Persian medicine.38 Participants in the trial used 15–20 drops of the tincture twice daily for six months. At the end of the trial, participants experienced significant reductions in triglycerides compared to those who took placebo. No adverse effects were reported.

2 Stars

Calcium

800 mg daily

Calcium supplementation has been shown to reduce triglyceride levels.

Caution: Calcium supplements should be avoided by prostate cancer patients.

In a preliminary trial, supplementation with 800 mg of calcium per day for one year resulted in a statistically significant 35% reduction in the average TG level among people with elevated cholesterol and triglycerides.39 However, in another trial, calcium supplementation had no effect on TG levels.40 One of the differences between these two trials was that more people in the former trial had initially elevated TG levels.

2 Stars

Chromium

200 mg daily

Studies have shown that chromium supplementation may reduce triglycerides in people with type 2 diabetes.

In a double-blind trial, 30 people with type 2 (non-insulin-dependent) diabetes received 200 mcg of chromium per day (as chromium picolinate) for two months and a placebo for an additional two months. The average TG level was significantly lower (by an average of 17.4%) during chromium supplementation than during the placebo period.41Some,42, 43 but not all, trials44, 45 support these findings. It is not clear whether chromium supplementation affects TG levels in non-diabetics, but some evidence suggests that it does not.46, 47, 48, 49, 50

2 Stars

Fenugreek

100 grams seed daily or 25 to 50 grams defatted seed powder daily

Fenugreek has been shown to lower total and LDL cholesterol and triglyceride levels in people with high lipid levels in preliminary trials..

Fenugreek has been shown to lower total and LDL cholesterol and triglyceride levels in people with high lipid levels in preliminary trials.51 Bread made with 50 grams defatted fenugreek powder was used twice daily in the trial. Similar results have been seen at half that amount in people with diabetes and elevated blood levels of various lipids.52 A small randomized trial found similar results using 100 grams fenugreek seeds daily.53 One small clinical trial found that either 25 grams or 50 grams per day of defatted fenugreek seed powder were effective in reducing triglycerides over a 20-day period.54 Mild diarrhea and gas can accompany the first few days of fenugreek use, though it almost always fades as the person taking it adapts.

2 Stars

Fructo-oligosaccharides

8 to 20 grams daily

Several trials have shown that FOS supplementation lowers triglycerides in people with elevated levels.

Several double-blind trials have evaluated the efficacy of fructo-oligosaccharides (FOS) or inulin (a related compound) for lowering blood cholesterol and triglyceride levels. These trials have shown that in individuals with elevated total cholesterol or triglyceride levels, including people with type 2 diabetes, FOS or inulin (in amounts ranging from 8 to 20 grams daily) produced significant reductions in triglyceride levels; however, the effect on cholesterol levels was inconsistent.55, 56, 57, 58 In people with normal or low cholesterol or triglyceride levels, FOS or inulin produced little effect.59, 60, 61

2 Stars

Garlic

600 to 900 mg daily of a concentrate standardized for 5,000 to 6,000 mcg of allicin

Supplementing with garlic may help keep triglyceride levels in check.

Reports on many clinical trials of garlic performed until 1998 suggested that triglycerides were lowered by an average of 8–27% and cholesterol by 9–12% over a one- to four-month period.62, 63, 64 Most of these trials used 600–900 mg per day of a garlic supplement standardized to alliin content and allicin potential. More recently, however, three double-blind clinical trials have found garlic to have minimal success in lowering triglycerides and cholesterol.65, 66, 67 One negative trial has been criticized for using a steam distilled garlic “oil” that has no track record for this purpose,68 while the others used the same standardized garlic products as the previous positive clinical trials. Based on these findings, the use of garlic should not be considered a primary approach to lowering high triglycerides and cholesterol.69

Odor-controlled, enteric-coated garlic tablets standardized for allicin content can be taken in the amount of 900 mg daily (providing 5,000–6,000 mcg of allicin), divided into two or three daily portions.

2 Stars

Inositol Hexaniacinate (Vitamin B3)

500 mg three times per day

Some doctors recommend inositol hexaniacinate (a special form of vitamin B3) as an alternative to niacin, which can have negative side effects.

The niacin form of vitamin B3 is used by doctors to lower cholesterol levels, but niacin also lowers TG levels. The amount of niacin needed to achieve worthwhile reductions in cholesterol and TG levels70 is several grams per day. Such quantities can cause side effects, including potential damage to the liver, and should not be taken without supervision of a doctor. Some doctors recommend inositol hexaniacinate (a special for of vitamin B3) as an alternative to niacin. A typical amount recommended is 500 mg three times per day.71, 72 This form of vitamin B3 does not typically cause a skin flush and is said to be safer for the liver than niacin. However, the alleged safety advantage of inositol hexaniacinate needs to be confirmed by addition clinical trials. Moreover, it is not clear whether inositol hexaniacinate is as effective as niacin at lowering cholesterol and TG levels.

2 Stars

Krill Oil

2 to 3 grams per day

Supplementing with krill oil may decrease triglycerides in people with elevated levels.

In a double-blind study of people with elevated blood levels of cholesterol and triglycerides, supplementation with 2 to 3 grams per day of krill oil from Antarctic krill (a zooplankton crustacean) for three months decreased levels of triglycerides. However, 1 to 1.5 grams per day was not effective. Krill oil was significantly more effective than either a placebo or small amounts of regular fish oil containing 900 mg per day of omega-3 fatty acids.73

2 Stars

L-Carnitine

1 to 3 grams daily

Supplementing with L-carnitine may help normalize triglyceride levels.

L-carnitine is another supplement that has lowered TGs in several clinical trials.74, 75 However, the effect of carnitine is unpredictable, and some individuals have experienced an increase in triglyceride levels after receiving this supplement.76 Some doctors recommend 1–3 grams of carnitine per day, in the form known as L-carnitine.

2 Stars

Policosanol

10 to 20 mg daily

Policosanol may be helpful in normalizing triglyceride levels.

The effect of policosanol on serum triglycerides has been inconsistent, ranging from no effect up to as much as a 19% reduction.77, 78, 79, 80, 81, 82, 83, 84, 85, 86 Several controlled studies have compared policosanol with cholesterol-lowering medications, such as statins, and have found policosanol similarly effective.87, 88, 89, 90, 91, 92, 93 Policosanol extracted from beeswax or other sources differs from the sugar-cane-derived preparation in the proportions of long-chain alcohols, and whether these types of policosanol are as effective as sugar-cane-derived policosanol is unknown.

2 Stars

Psyllium

15 grams daily

Psyllium seeds and husks have shown a modest ability to lower blood triglyceride levels in some clinical trials.

Psyllium seeds and husks have shown a modest ability to lower blood triglyceride levels in some,94, 95 but not all,96 clinical trials. Further research is needed to assess the effect of psyllium on triglyceride levels more closely, as much of the study so far has focused on lowering cholesterol levels.

2 Stars

Red Yeast Rice

13.5 mg total monacolins daily

Although primarily used to lower high serum cholesterol, red yeast rice extract, high in monacolins, has been found to significantly lower serum triglyceride levels.

Although primarily used to lower high serum cholesterol, red yeast rice extract, high in monacolins, has been found to significantly lower serum triglyceride levels.97 People in the trial took 1.2 grams (approximately 13.5 mg total monacolins) of a concentrated red yeast rice extract per day for two months. The sale of Cholestin has been banned in the United States, as a result of a lawsuit alleging patent infringement. Other red yeast rice products currently on the market differ from Cholestin in their chemical makeup. None contain the full complement of 10 monacolin compounds that are present in Cholestin, and some contain a potentially toxic fermentation product called citrinin. 98 Until further information is available, red yeast rice products other than Cholestin cannot be recommended.

1 Star

Creatine Monohydrate

Refer to label instructions

One trial found that supplementing with significantly lowered serum total triglycerides in both men and women.

A double-blind trial found that a supplement of 5 grams of creatine plus 1 gram of glucose taken four times per day for five days followed by twice a day for 51 days significantly lowered serum total triglycerides in both men and women.99However, another double-blind trial found no change in any of these blood levels in trained athletes using creatine during a 12-week strength training program.100 Creatine supplementation in this negative trial was lower—only five grams per day was taken for the last 11 weeks of the study.

1 Star

Green Tea

Refer to label instructions

Drinking green tea may have a positive effect on triglyceride levels.

Intake of three cups or less of green tea daily has been shown not to affect blood triglyceride levels.101 Intake of four or more cups per day has been correlated with lower triglyceride levels.102 Overall, the evidence is unclear on how much of an effect high levels of intake of green tea has on triglyceride levels.

1 Star

Maitake

Refer to label instructions

Studies suggest that the mushroom maitake may lower fat levels in the blood.

Animal studies suggest the mushroom maitake may lower fat levels in the blood.103 However, this research is still preliminary and requires confirmation by controlled human trials.

The information presented in Aisle7 is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. Self-treatment is not recommended for life-threatening conditions that require medical treatment under a doctor's care. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires June 2015.

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