Natural killer (NK) cells are lymphocytes that mediate cytotoxicity and secrete cytokines after immune stimulation. Additionally we are shipping KLRB1 Proteins (14) and many more products for this protein.

CD161 expression levels were reduced in some NK and T cell subpopulations of systemic lupus erythematosus (SLE) patients, suggesting possible important role of CD161 and CD161-expressing immune cells in the SLE pathogenesis.

A novel population of highly functional, memory CD8+ T cells enriched within the gut expresses CD161.

Our results reveal that in combination with IGRAs, CD161-based indices provide a novel, fast diagnostic solution addressing the limitation of current tuberculosis diagnostics.

these data suggest that LLT1 (show CLEC2D Antibodies)-CD161 interactions play a novel and important role in B cell maturation (show TNFRSF17 Antibodies) within the Germinal center in humans.

The regulation of NK cell homeostasis and activation apparently differs between carriers of the CC and TT variant of CD161.

We suggest modulation of human Th17 responsiveness by CD39 and CD161 and describe novel molecular mechanisms integrating elements of both extracellular nucleotide and sphingolipid homeostasis--{REVIEW}

these results suggest that the CD8(+) subset of CD161(+) T cells may have regulatory effects and that they provide a basis for predicting the occurrence of aGVHD after allogeneic SCT.

CD161-expressing Th17 cells are enriched at sites of autoinflammation, are highly proinflammatory and resistant to Treg-mediated suppression suggesting their important pathogenic role in rheumatoid arthritis.

KLRB1 Antigen Profile

Protein Summary

Natural killer (NK) cells are lymphocytes that mediate cytotoxicity and secrete cytokines after immune stimulation. Several genes of the C-type lectin superfamily, including the rodent NKRP1 family of glycoproteins, are expressed by NK cells and may be involved in the regulation of NK cell function. The KLRB1 protein contains an extracellular domain with several motifs characteristic of C-type lectins, a transmembrane domain, and a cytoplasmic domain. The KLRB1 protein is classified as a type II membrane protein because it has an external C terminus.