During the day we will introduce the CRM design, run a CRM trial, provide training on the features in designing a CRM, move onto ideas for making a grant application, then consider planning in the set-up and running of a CRM trial.

Sessions will be led by trial statisticians and trial managers with experience in designing, conducting and analysing dose-finding trials, mainly but not exclusively in oncology settings.

Target audience: This course is designed for anyone running a phase I dose finding trial who wants to learn more about the CRM. The course focuses on the CRM concept and practicalities, rather than the pure associated statistical methodology, and is aimed at clinicians, data managers, trial managers and statisticians, in both academic and pharmaceutical institutions.

Course requirements: Knowledge of phase I trials would be beneficial. Algorithm based designs (e.g. 3+3) will be compared to but not covered in detail.