Bottom Line:
Instead, we found that the ECM regulated GPx activity, a known H2O2 scavenger.Thus, our results unraveled a new mechanism by which the ECM regulates endothelial cell function by altering redox balance.These results pinpoint the ECM as an important component of redox-signaling.

Bottom Line:
Instead, we found that the ECM regulated GPx activity, a known H2O2 scavenger.Thus, our results unraveled a new mechanism by which the ECM regulates endothelial cell function by altering redox balance.These results pinpoint the ECM as an important component of redox-signaling.