An experiment was conducted on newly weaned rabbits for eight weeks by fattening them on diets supplemented with corn steep liquor (CSL) replaced 0, 10, 20, and 30% of crude protein and energy of barley and soybean meal of the diets. The obtained results refer to increased feed intake (thus, worst the feed conversion and economic efficiency); serum cholesterol, triglycerides, and low density lipoproteins (referring to somewhat negative effect on liver function, where the serum alanine aminotransferase activity was decreased too); as well as hemoglobin concentration and red blood cells count (as good indicators). Otherwise, there were no significant effects on growth performance, water intake, edible parts, digestibility, and muscular composition. So, it could be concluded that dietary inclusion of CSL (up to 30%) for rabbits is possible without adverse effects on performance and health state.