Immunostimulatory therapies that activate immune response pathways are of great interest for overcoming the immunosuppression present in advanced tumors. Agonistic antibodies against the co-stimulatory receptors CD40 and ...

The dissemination of lymphoma into anatomical compartments that are poorly accessible from circulation, such as lymph nodes, necessitates high doses of systemic chemotherapy. However, the potencies of many chemotherapeutic ...

Mechanical forces play an important role in cell morphology, orientation, migration, adhesion and can even induce apoptosis. The eukaryotic cell is equipped with a dynamic frame, known as the cytoskeleton, that provides ...

Surface-based sensors take advantage of the natural high surface-to-volume ratios in microfluidic devices, low reagent consumption and high potential for integration in more complex micro total analysis systems (microTAS ...

The physical properties of a cell are manifestations of its most basic molecular and metabolic processes. In particular, size has been a sought metric, which can be difficult to ascertain with great resolution or for smaller ...

Osteoarthritis is characterized by synovial joint degeneration, and its cardinal pathological feature is degeneration and loss of the articular cartilage joint surface. While the aetiology of osteoarthritis is unknown, ...

Alkyl-substituted anilines have been implicated as important etiological agents in human carcinogenesis. Specifically, 2,6-dimethylaniline (2,6-DMA), 3,5-dimethylaniline (3,5-DMA), and 3-ethylaniline (3EA) have been ...

One of the primary goals of cancer chemotherapy is the design of antitumor agents that achieve selective targeting of tumor cells while minimizing toxicity to normal tissues. We have synthesized a series of DNA damaging ...

Molecular design of novel pharmaceutical agents depends on a mechanistic paradigm. A library of compounds was designed to mimic some features of cisplatin that are believed to be in part responsible for its success as a ...

Eight distinct nuclear shapes, or morphologies, have been discovered in human proto-organs and tumors, including bell-shaped nuclei with stem-like properties. These bell-shaped, or "metakaryotic," nuclei are abundant in ...

Analysis of single cells using flow cytometry techniques has created a wealth of knowledge about cellular phenomena that could not be obtained by population average measurements. As these techniques are integrated with ...

The primary motivation for this work is the manipulation of EGFR family signaling to influence regenerative responses of mesenchymal stem cells (MSC). Underlying the potential of regenerative medicine is the need to ...

The objective of this work is to functionalize an existing polymer such that it better mimics natural tissue for tissue growth and regeneration. Numerous other processes have tried and accomplished this by non-specific ...