no periods or a lack of menstrual periods not due to pregnancy (amenorrhoea)

as part of combination hormone replacement therapy with oestrogens to reduce menopause symptoms (e.g., hot flushes). Medroxyprogesterone is added to estrogen replacement therapy to reduce the risk of cancer of the uterus.

Medroxyprogesterone is available as tablets.

It is also available as a long-acting injection, called Depo-Provera which is used as a contraception.

Dose

The dose of medroxyprogesterone will be different for different people. Your dose will depend on what you are being treated for.

You may be asked to take the tablets every day, or only on certain days of your period.

Always take your medroxyprogesterone exactly as your doctor has told you. The pharmacy label on your medicine will tell you how much medroxyprogesterone to take, how often to take it, and any special instructions.

How to take medroxyprogesterone tablets

Swallow the tablets whole with a full glass of water.

Try to take medroxyprogesterone at the same time each day, as this will help you to remember to take them.

You can take medroxyprogesterone with or without food.

If you forget to take your dose, take it as soon as you remember that day.

But, if it is nearly time for your next dose, just take the next dose at the right time. Do not take double the dose.

Possible side effects

Like all medicines, medroxyprogesterone can cause unwanted side effects, although not everyone gets them.

Side effects

What should I do?

Feeling sick (nausea)

Headache

Mood changes

These are quite common when you first start taking medroxyprogesterone and usually go away with time

Tell your doctor if troublesome

Changes in weight

Difficulty sleeping

Bloating

Swollen feet and ankles (fluid retention)

Breast tenderness

Changes in sexual desire

Tell your doctor if troublesome

Allergic reaction including any skin rashes, itching, blisters, peeling skin, swelling of the face, lips, mouth or have problems breathing

Tell your doctor immediately or ring HealthLine 0800 611 116

Interactions

Medroxyprogesterone may interacts with a number of important medications and herbal supplements so check with your doctor or pharmacist.

Learn more

The following is further reading that gives you more information on medroxyprogesterone.

Information for clinicians

Medsafe Data Sheets

Drug Formulary NZ

Best Practice Update (BPAC)

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