Radiation: Whole brain radiotherapy with reduced dose to the hippocampi

Interventional

Sheba Medical Center

Other

Intervention Model: Single Group Assignment

Masking: None (Open Label)

Primary Purpose: Prevention

Number of patients that complete a year of imaging, neuro-cognitive and clinical follow up after WBRT with HC sparing as a measure of feasibility to conduct a randomized study in this patient population.

Number of patients with no changes in the neurocognitive tests score and QOL as a measure for the correlation between NCT and HC sparing.

Number of patients with no changes in serum markers for neuronal damage and as a measure for reduced damage due to hippocampal sparing

Number of patients with changes in imaging biomarkers (TRAM) and neurocognitive tests score decline as a measure for a potential correlation between the two.

Allow sample acquisition for use in the study of thoracic malignancies except mesothelioma.

Follow the natural history of patients with thoracic malignancies.

Conduct genomic, proteomic and immunological analyses on blood, tumor, body fluid and normal tissue in support of NIH translational trials to develop new therapeutic agents and novel treatment approaches as well as new prognostic and diagnostic ...

2000

All

18 Years to 100 Years (Adult, Senior)

NCT02146170

14010514-C-0105

May 8, 2014

April 30, 2024

April 30, 2025

May 23, 2014

February 14, 2018

National Institutes of Health Clinical Center, 9000 Rockville PikeBethesda, Maryland, United States