Adapalene is a third-generation topical retinoid primarily used in the treatment of mild-moderate acne and is also used (off-label) to treat keratosis pilaris as well as other skin conditions.It is currently marketed by Galderma under the trade names Differin in some countries, and Adaferin in India. In the United States, Adapalene is now being distributed as "Epiduo (TM) Gel." This acne treatment which is new to the market also contains benzoyl peroxide.