My sites getting hacked - what do I do?

My sites keep getting hacked, is there anything I can do to prevent that? I heard that I can change my adminstration url, so change the: mysite.com/adminsitrator to like something else, will that help? Can anyone please suggest something solid? Thank you!

I had a couple of sites get hacked. They were using an apache exploit to change the title page. I don't recall exactly what the hostgator support guys did to fix it, but they had everything fixed in about an hour with no problems since.

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