I tried Retin A, Differin, and Tazorac. None of them were effective for me and I found them inconvenient. I eventually went with Accutane and it worked. It didn't provide me with a "cure" but it was definitely the most effective thing and aside from the dryness it was convenient and easy to deal with. The results were really good while I was on the drug and lasted for several months afterward. I'm once again on Accutane for sebaceous hyperplasia (large clogged pores) and it's working well. This is just my personal experience. Some people get good results from topical treatments.