Discontinuation of antihypertensive drugs appears to have a detrimental effect, with a recent study reporting that the risk of acute myocardial infarction (AMI) substantially increases after more than 90 days of discontinuation.

Prediagnostic statin exposure appears to be associated with a significant reduction in breast cancer-specific mortality, with the survival benefit being more pronounced in women with oestrogen receptor (ER)-positive tumours, according to a study.

Nausea at the time of dosing does not reduce the efficacy of diclofenac potassium for oral solution (DPOS) in acute migraine treatment, while prior triptan use predicted poor headache response compared with triptan-naïve patients, according to a study.

The pooled population from two double-blind trials included 1,272 patients aged 18–65 years (85 percent female) with at least a 1-year history of migraine attacks with or without aura who were randomized to receive 50 mg DPOS (n=628) or placebo (n=644). Participants were evaluated at 1, 2, and 8 hours postdosing to determine the intensity of migraine outcomes such as headache, photophobia, or phonophobia.

The similar findings suggest that DPOS was effective regardless of presence of nausea at baseline, noted the researchers. “The rapid absorption profile [of DPOS] may enhance the effectiveness in patients with nausea,” they said.

Prior triptan use did not predict relief of other measured parameters (ie, photophobia, phonophobia, or nausea) at 2 hours.

“These results suggest there may be a subset of patients who are more likely to be refractory to both triptans and diclofenac,” said the researchers, noting that this would require further investigation.

With previous evidence showing baseline nausea as a predictor of poor response to migraine treatment with triptans, it would be important to identify other migraine medications such as DPOS for effectively treating patients with poor triptan response, they added.

Discontinuation of antihypertensive drugs appears to have a detrimental effect, with a recent study reporting that the risk of acute myocardial infarction (AMI) substantially increases after more than 90 days of discontinuation.

Prediagnostic statin exposure appears to be associated with a significant reduction in breast cancer-specific mortality, with the survival benefit being more pronounced in women with oestrogen receptor (ER)-positive tumours, according to a study.