GUIDELINES FOR BRCA TESTING TO IDENTIFY HEREDITARY RISK

Traditionally, the purpose of BRCA testing in patients with breast cancer has been to evaluate hereditary risk in unaffected relatives.

The National Comprehensive Cancer Network (NCCN), European Society for Medical Oncology (ESMO) and American Society of Breast Surgeons (ASBS) are all examples of organisations that produce guidelines that describe the criteria that individuals must meet, in order to be eligible for BRCA testing to assess hereditary risk of breast cancer[1,2,3].

A young age at onset, a family history of breast or ovarian cancer, specific ethnicities associated with known founder BRCA mutations e.g. Ashkenazi Jews and cases of triple negative breast cancer are all factors that are considered in the selection of individuals for BRCA testing for hereditary risk assessment[1,2].

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