Results: α-Eudesmol did not influence MAP, CBF, blood gas or blood electrolyte parameters. Pharmacological inhibition of Cav2.1 channels led to a dose-dependent reduction in brain water content 24 hours after trauma. After i.c.v. injection of the drug in concentrations of 100 nmol, 500 nmol and 1 mmol, the brain water content was significantly lower in the traumatized as well as in the non-traumatized hemisphere compared to control animals. While α-eudesmol at 100 nmol significantly reduced ICP after 24h and tended to reduce lesion volume, no further impovement was detected at higher doses. When it was applied after trauma at a low dose (100nmol), no significant changes occurred.