In terms of volume, I'm thinking you're gonna have to rub a lot of ethanol-laden DMSO into your skin to absorb an intoxicating amount of ethanol. Is that so? or is intoxication a function of concentration AND rate, i.e. will the faster uptake of alcohol allow a smaller amount to achieve intoxication?

Also, what about THC. Does the THC actually need to combust before it's active, or can it be transdermally applied as well?

Alcohol is a TOXIN.As a fire-breathing bartender, we sometimes used to use Stroh 80 for the afore-mentioned fire-breathing - blisters all over the mouth the next day were the inevitable result...Trust me, EtOH + DMSO through the skin in enough quantities to get you drunk is going to require hospitalisation to replace the skin....

Do not ever use DMSO to absorb things like GBL or EtOH. Also, do not ever attempt to shoot either chemicals by IV, unless you're able to setup a sterile IV saline drip and keep the concentrations very low (ie similar to blood alcohol/gbl levels found in intoxicated people).