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Epidemiology

The septum pellucidum is partly or entirely absent in 2 or 3 individuals per 100,000 in the general population.

Pathology

An absent septum pellucidum may be developmental or acquired secondary to another pathological process 1,2.

Cavum septum pellucidum is always visualized between 18 and 37 weeks and within a biparietal diameter of 44 to 88 mm. Failure to detect the cavum septum pellucidum within this time interval requires further investigation. However, the absence of cavum septum pellucidum on the ultrasound exam prior to 18 weeks or later than 37 weeks is considered a normal finding.