John, you are not providing enough information for anyone to help you.

Apparently there's not going to be a "Make the Apps Work Again" application tailored for your system.

You'll need to learn a few things and dig a little deeper. Look in your event logs for messages that describe what went wrong at the time you tried and failed to run an app. Post the information here. Someone here may be
able to use that information to describe in much greater detail what you can do to get things working again.

It thinks that it fixed something. Did it? What specifically did it change (or try to) and how long does it persist? FWIW I would run ProcMon to try to capture supplementary details to help explain whatever those other diagnostics
are saying (or think they are saying). Since it is looking like some kind of permissions problem have you tried creating another account and seeing if it can act as a workaround?

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