They will do fine in there, they can handle higher volumes pretty well, although they aren't as powerful as compression driver speakers like Klipsch Reference, and the treble won't be as hot. They would be better for large rooms than typical dome tweeter on a flat baffle, like Polk, Energy, and so on. A Hsu caliber sub is definitely going to be needed in that space.

The sub is probably fine but for close to $1000 with shipping for the other 5 I am sure that you can do better than 5 bookshelf speakers. Dont care if they are Hsu or not. Especially for a room that size. Bics are fine speakers and use horn tweeters. Many people say that they sound very similar to the Klipsch that your friend has. Get you a couple of towers for around $500 and spend the rest on a nice center and a couple of decent surround speakers.
What kind of Yamaha receiver do you have? I have the RX-V671 and I love it.

The sub is probably fine but for close to $1000 with shipping for the other 5 I am sure that you can do better than 5 bookshelf speakers. Dont care if they are Hsu or not. Especially for a room that size. Bics are fine speakers and use horn tweeters. Many people say that they sound very similar to the Klipsch that your friend has. Get you a couple of towers for around $500 and spend the rest on a nice center and a couple of decent surround speakers.
What kind of Yamaha receiver do you have? I have the RX-V671 and I love it.

Thanks for the replies,

I have an older HTR-6030, I will check out the RX. I have a new mitsubishi 82 inch dlp and it has 3 hdmi inputs, just enough for my dbs, xbox and blu ray player. My receiver also has just enough audio inputs (1 coax, 2 optical) so it works for now, but I know I need to upgrade.

Thanks for the replies,
I have an older HTR-6030, I will check out the RX. I have a new mitsubishi 82 inch dlp and it has 3 hdmi inputs, just enough for my dbs, xbox and blu ray player. My receiver also has just enough audio inputs (1 coax, 2 optical) so it works for now, but I know I need to upgrade.

If you are patient and diligent you can probably find the 671 for around $300 for Christmas. Amazon just had it for $299. MSRP is $599 but it usually sells for around $450. I paid $385 and have no regrets.