Liverpool are likely to make just one change from the draw at Sunderland last weekend, with Jose Enrique returning to Brendan Rodgers’ side in place of Martin Kelly.

Fabio Borini and Raheem Sterling, both substitutes in the 5-3 win at Young Boys on Thursday, should come back into the starting line-up to provide support for Luis Suarez, who was not in the squad for their Europa League encounter.

Wayne Rooney and Ashley Young are still too unfit to feature, although Rooney may return next week, but the former Aston Villa is still three weeks away from a comeback. Robin van Persie is likely to lead the line, with support from Shinji Kagawa.

David de Gea was in goal for the Red Devils’ 1-0 win over Galatasaray in midweek and is set to keep his place between the posts, and Alexander Buttner may retain his place in the XI after a goalscoring performance against Wigan last weekend.

DID YOU KNOW?

In their last five Premier League meetings, both sides have been on the scoresheet; the last time a side kept a clean sheet in this fixture was in October 2010 when Liverpool won 2-0.

Brendan Rodgers’ side are still looking for their first clean sheet of this season, having kept 11 in the Premier League last year

Liverpool have had 75 shots so far this season – the most in the league – but only 15 of them have been on target.

Luis Suarez (pictured right) has created more goalscoring chances than anyone in the Premier League (12), but has yet to register an assist.

Nemanja Vidic and Michael Carrick are the only two players to have started all four Premier League games for Manchester United this term.

Danny Welbeck has yet to have a shot on target in the Premier League, despite 10 attempts so far this season; seven of them came in last week’s win over Wigan.

Players to watch

The 20-year-old looks to have come on leaps and bounds this season, showing real signs of maturity when filling in the void left by long-term absentee Lucas.

The midfielder bagged a brace in the Reds’ dramatic 5-3 win over Young Boys in the Europa League on Thursday, and will be keen to show he has what it takes in the big games, with Liverpool still searching for that elusive first win in the league.

Full-back Buttner enjoyed the kind of Old Trafford debut last week that is usually confined to the dreams of 8-year-olds, scoring one and setting up another in the 4-0 demolition of Wigan, while also showing an impressive calmness when required to defend.

The young Dutchman has exploded on to the scene in England and, if he gets the nod, will look to cause problems going forward.

Editor's Prediction

It has been an emotional week in the North West after the Hillsborough report's release, but both sets of fans will be desperate for a result against their fiercest rivals. United are on top form at the moment and are looking for their fourth straight Premier League win.

Brendan Rodgers’ side will be buoyed by their win in Switzerland in midweek, but United have had an extra day’s rest, having played Galatasaray on Wednesday, and they have the form and the talent to come away from Anfield with all three points.