Available hosts

Available applications

Background of INPP5B / 5PTase 2 antibody

Cellular calcium sigling is controlled by the production of inositol phosphates (IPs) by phospholipase C in response to extracellular sigls. The IP sigling molecules are ictivated by a family of inositol polyphosphate-5-phosphatases (5-phosphatases). INPP5B is the type II 5-phosphatase. The protein is localized to the cytosol and mitochondria, and associates with membranes through an isoprenyl modification near the C-terminus.Cellular calcium sigling is controlled by the production of inositol phosphates (IPs) by phospholipase C in response to extracellular sigls. The IP sigling molecules are ictivated by a family of inositol polyphosphate-5-phosphatases (5-phosphatases). This gene encodes the type II 5-phosphatase. The protein is localized to the cytosol and mitochondria, and associates with membranes through an isoprenyl modification near the C-terminus. Several altertively spliced transcript variants of this gene have been described, but the full-length ture of some of these variants has not been determined.