Objective: To determine the seroprevalence of anticardiolipin antibodies (aCL) in primipararous women, whether aCL are associated with abnormal pregnancy outcome and if treatment with aspirin had any effect on pregnancy outcome in aCL positive primiparae. Design and Method: A prevalence survey of a CL was don among 924 primiparae, a sub-sample of 6275 primiparae, who were enrolled in the Jamaica low dose aspirin trial. Anticardiolipin antibodies were measured in serum samples by the standardized anticardiolipin enzyme linked immunosorbent assays (ELISA). Samples were assayed for both b2 glycoprotein 1 dependent and b2 glycoprotein 1 independent aCL. (AU)....read more