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Hello, this is swims first post. She was wondering if anyone remembers on Rhodium.ws in the pharmacology section, where info about meth usage was, where it listed a couple of amino acids that were very good in restoring the bodies dopamine levels, et al... Swim remembers one of them to be L-Tyrosine but can't remember the other. She can state personally that working progressively up to a high dosage of L-Arginine, Ornithine daily on an empty stomach before bed does absolute wonders in terms of 'spring out of bed in the morning' type energy. Who else has some info on helpful amino's etc... ??? Swim met a health supplement store owner once who talked about the intense need for a meth abuser to detoxify their body and listed a whole bunch of specific supplements, swim has lost that list and the contact with the person, anyone know whatzzup?

From memory I remember that phenylalanine was recommended (as dopamine precursor).

But from own experience and from what I have seen I would very much recommend antidepressiva for meth-withdrawal to avoid the traumatisation. The "all the world is grey" symptom is not to beat by supplements only.

SWIM has found that amino acids greatly reduce tolerance speed up the recovery process after using dopaminergic stimulants. Because l-tyrosine and l-tryptophan were too expensive in SWIM's area he decided to use amino acids used by body builders in their diet. They surely helped him. SWIM recommends them while doing binges, too. They give the body the suppliesss of Amino acids it needs for metabolism thus preventing the break down of its own proteins. SWIM has found that using a carbohydrate and protein supplement in combination with speed has somewhat of anabolic effect for him. He doesn't get fat but his body builds muscles.

SWIM has found that amino acids greatly reduce tolerance speed up the recovery process after using dopaminergic stimulants. Because l-tyrosine and l-tryptophan were too expensive in SWIM's area he decided to use amino acids used by body builders in their diet. They surely helped him. SWIM recommends them while doing binges, too.

Good recco... in a pinch, deli lunch meats or anything else high in protein are very helpful as well.

This nutrient is part of the raw material used by the brain to create and replenish the neurotransmitters noradrenaline (which is the brain's version of adrenaline), and dopamine. These are "excitatory" neurotransmitters which your brain uses to feel happy and alert. Stimulants, like caffeine, serve to release but not replenish neurotransmitters like these.
It's an amino acid; one of 22 known amino acids. Amino acids are something you eat every day, in the form of protein. The word protein just refers to amino acids that come in a group. When you eat a steak, for instance, you're not just eating phenylalanine, you're also eating leutine, lysine, glutamine, etc. You're eating a whole bunch of amino acids. You actually get totally different effects by taking this amino acid alone than when you get it in food, precisely because the amino acids in food come in a whole bunch.

You see, your blood stream has little 'amino acid transport molecules'. These transport amino acids across and through a barrier between your body's bloodstream and that of your brain. In this way, everything that goes from your primary bloodstream into the bloodstream of your brain is filtered. Your body is probably designed like this because it is just so darn important to your general functioning, it's important to be picky about who gets in there. Now, this filtering type phenomenon I've just described presents a problem. There are only so many of these transport molecules -- these little amino acid ships, if you prefer-- to take amino acids to your brain... so all of the amino acids in your bloodstream compete for the limited number of ships. It's like people pining for a ship to a better country - only so few can get through.

You need to take this amino acid on an empty stomach. That way, there's no competition for these amino acid ships. It's easy to be the life of the party when you're the only one that shows up! As much phenylalanine as there are ships 'jump aboard' and go directly to your brain.... and you feel good.
To get the full effects I've listed above, you should also take vitamins B-6 and C with the phenylalanine. Vitamin B-6 is kind of like a 'trigger' or 'command' nutrient. It tells your brain to start converting other nutrients -- like phenylalanine -- into neurotransmitters. Your body uses vitamin C as a building block for certain chemicals. In fact, it's also used in part to make the neurotransmitters noradrenaline and dopamine. So you should be sure to take plenty of Vitamin C with your phenylalanine, as well.

One of the combinations you can try is this: 500 mg phenylalanine
25 or 50mg Vitamin B-6
1000 mg Vitamin C

Get them in capsules, if you can. Tablets are rarely fully digested.
Take this mixture on an empty stomach.Take no more than two and a half grams of phenylalanine a day.
The best time to take this nutrient is right in the morning, shortly after you wake up and before eating anything. After ingesting, wait about an hour to eat, to ensure that the amino acid and other nutrients have had plenty of time to work their magic.

It is recommended that you donít consume phenylalanine while on methamphetamine because it regulates body temperature so it fights with the meth and can have unpleasant side effects. If anyone has more information on how these 2 chemicals interact SWIM would be very interested to learn more.

Taurine is an amino acid which plays a major role in the brain as an "inhibitory" neurotransmitter & neuromodulator. It is similiar in structure to the amino acids GABA & L-Glycine, which are also neuroinhibitory. This means it helps to calm or stabilize an excited brain.

Taurine acts by regulating the sodium & potassium concentration in the cells & the magnesium level between the cells. This has everything to do with the electrical activity of the cells & subsequent communication between cells.

By this mechanism, it has anti-anxiety & anti-convulsant activity. It has also been found useful in some cases of migraine, insomnia, agitation, restlessness, irritability, alcoholism, obsessions, depression, hypomania/mania.

Dosage is from 500 mg twice daily to a total of 5000 mg daily in 3-4 divided doses, though I rarely recommend that high a dose. The total ideal body pool of taurine for adults is 12,000- 18,000 mg.

Since taurine also affects the hypothalamus to help regulate body temperature, a higher dose can decrease your temperature & give chilliness, so be aware of that.

Taurine also plays a role in memory & increases the level of a memory neurotransmitter, acetylcholine, in the brain (in animal studies).

HOW DO YOU GET TAURINE?

Taurine is highly concentrated in animal & fish protein or organ meats. Strict vegetarians can be at risk for taurine deficiency. Your body can make taurine in the liver & brain from the amino acids, L-Cysteine, & L-Methionine. Three enzymes are involved in the conversion, all requiring the pyridoxal-5-phosphate form of Vitamin B6 for this conversion. A B6 deficiency can thus cause a taurine deficiency.

Some studies suggest humans are dependent upon dietary taurine to maintain "adequate" taurine reserves. Females tend toward lower taurine levels than males as their production pathways don't work as efficiently.

Taurine is closely bound to zinc & manganese so deficiencies of either of these can interfere with its' utilization. Likewise, zinc & manganese enhance the effects of taurine.

Taurine is the amino acid present in highest concentration of all amino acids in the fetal & newborn brain, which is the most dependent upon taurine & the least able to synthesize it.. The developing infant must derive taurine from the placenta, the newborn, from breast milk or taurine fortified formula. It is low in cow's milk. Taurine is essential for proper development of the central nervous system & the eyes. Nursing mothers especially need taurine as it stimulates prolactin to promote lactation, which is an interesting twist of nature, since infants need it so much. ( We could speculate that a mother unable to lactate may be taurine deficient, among other possibilites, & the infant is thus protected from receiving taurine deficient breast milk) Premature infants are especially prone to taurine deficiency.

WHAT ELSE INFLUENCES TAURINE LEVELS?

MSG can decrease taurine. Trauma, surgery, radiation therapy, burns, muscle diseases, steroid use, intestinal dysfunction with bacterial overgrowth of the small bowel can all lead to excess loss of taurine in the urine & subsequent deficiency.

EYES: It is in high concentration in the eyes where it has multiple functions to maintain normal retinal structure & function. Depletion leads to degeneration of the photoreceptor cells. Degenerative changes in the retinas of taurine deficient cats & dogs resemble retinitis pigmentosa. Taurine may be helpful in preventing cataracts. Age related macular degeneration has responded favorably to "injected" taurine as reported by American Biologics Mexico Hospital.

CARDIOVASCULAR: Taurine is the most abundant amino acid in the heart, a particularly electrically excitable tissue, as are the brain & eye. Since taurine participates in electrical stabilization of the cell membranes & the normal regulation of nerve-muscle interaction, it is useful in heart irregularities & mitral valve prolapse, acting similarly to a calcium channel blocker (a class of drugs used in CV Disease) Taurine also helps control high blood pressure & is useful in congestive heart failure.

FAT METABOLISM: Taurine reduces cholesterol by forming bile acids which are the end products of cholesterol breakdown & are the only route for eliminating cholesterol from the body. This action requires a functioning gall bladder. Taurine has an inhibitory effect on the formation of cholesterol gall stones. It is required for efficient fat absorption & solubilization. It is helpful in states of fat malabsorption such as with cystic fibrosis & other pancreatic deficiency syndromes.

Didn't want to double post, so heres the link to SWIMS post in the thread "Anxiety - methamphetamine withdrawal" which has a list of supplements SWIM has started taking plus a bit on her experiences so far with Taurine.

SWIM has been taking both Phenylalanine and Taurine daily for a couple of weeks now, and although it is really hard trying to figure out what is doing what to her, overall she has not found Phenylalanine to be very effective, it seems to decrease SWIMS mania a little bit but no real energy kick. She thinks Taurine has helped to lessen anxiety, without causing the drowsiness experienced when taking prescription antianxiety medication.

Have you heard of the Prometa treatment? I have heard good and bad opinions of the programs long term effectiveness, but a big part of their treatment is administration of numerous vitamins and supplements.
Unfortunately, they keep the names of the exact compounds out of public view (mine anyway!) but maybe someone else here knows more about it.

Saw an article that said if taken regularly tyrosine causes the brain to build more dopamine receptor sites.This was in the context of treating reward defict syndrone,but personally I found it a positve aid to recovery.

There is something to be said for turning to the world of physical fitness when one's mind is falling apart.

Also, yes, L-tyrosine is very good. A site about the Biochemistry of Parkinson's Disease (as lack of dopamine has been related to parkinson's disease) notes how L-tyrosine --> L-dopa --> dopamine. Without L-tyrosine, there can be no dopamine.
Hope this helps.

Last edited by up.and.running06; 29-04-2013 at 23:45.
Reason: Automerged Doublepost

This nutrient is part of the raw material used by the brain to create and replenish the neurotransmitters noradrenaline (which is the brain's version of adrenaline), and dopamine. These are "excitatory" neurotransmitters which your brain uses to feel happy and alert. Stimulants, like caffeine, serve to release but not replenish neurotransmitters like these.
It's an amino acid; one of 22 known amino acids. Amino acids are something you eat every day, in the form of protein. The word protein just refers to amino acids that come in a group. When you eat a steak, for instance, you're not just eating phenylalanine, you're also eating leutine, lysine, glutamine, etc. You're eating a whole bunch of amino acids. You actually get totally different effects by taking this amino acid alone than when you get it in food, precisely because the amino acids in food come in a whole bunch.

You see, your blood stream has little 'amino acid transport molecules'. These transport amino acids across and through a barrier between your body's bloodstream and that of your brain. In this way, everything that goes from your primary bloodstream into the bloodstream of your brain is filtered. Your body is probably designed like this because it is just so darn important to your general functioning, it's important to be picky about who gets in there. Now, this filtering type phenomenon I've just described presents a problem. There are only so many of these transport molecules -- these little amino acid ships, if you prefer-- to take amino acids to your brain... so all of the amino acids in your bloodstream compete for the limited number of ships. It's like people pining for a ship to a better country - only so few can get through.

You need to take this amino acid on an empty stomach. That way, there's no competition for these amino acid ships. It's easy to be the life of the party when you're the only one that shows up! As much phenylalanine as there are ships 'jump aboard' and go directly to your brain.... and you feel good.
To get the full effects I've listed above, you should also take vitamins B-6 and C with the phenylalanine. Vitamin B-6 is kind of like a 'trigger' or 'command' nutrient. It tells your brain to start converting other nutrients -- like phenylalanine -- into neurotransmitters. Your body uses vitamin C as a building block for certain chemicals. In fact, it's also used in part to make the neurotransmitters noradrenaline and dopamine. So you should be sure to take plenty of Vitamin C with your phenylalanine, as well.

One of the combinations you can try is this: 500 mg phenylalanine
25 or 50mg Vitamin B-6
1000 mg Vitamin C

Get them in capsules, if you can. Tablets are rarely fully digested.
Take this mixture on an empty stomach.Take no more than two and a half grams of phenylalanine a day.
The best time to take this nutrient is right in the morning, shortly after you wake up and before eating anything. After ingesting, wait about an hour to eat, to ensure that the amino acid and other nutrients have had plenty of time to work their magic.

It is recommended that you donít consume phenylalanine while on methamphetamine because it regulates body temperature so it fights with the meth and can have unpleasant side effects. If anyone has more information on how these 2 chemicals interact SWIM would be very interested to learn more.

Really great post.

But may I please ask about the need to take a certain amino acid (tryptophan or tyrosine) on a empty belly because they won't compete with other amino acids..... but, if you take lets say 2 pills of tryptophan = 1000mg with food, then would tryptophan have the main lead??.

And or, could one take like 1500mg of tyrosine and 2500mg of tryptophan at the same time?. for example to trick around with the brain maybe? what would it produce?.

Hey this is my first post. SWIM works at GNC and knows a lot about supplements and an adder all user him/herself and borderline almost becoming an addict. "mucuna pruriens" I'm surprised no one has talked about because it has 20% L-Dopa in it which transforms into dopamine in the brain. Alpha-GPC will help with increased cognitive function and damage to membrane in brain. B-Complex vitamins are essential for healthy nervous system function. Taurine is also huge for healthy nervous system. L-Tyrosine also precursor for many neurotransmitters. Alpha-Linoic-Acid is a powerful antioxidant that is both water and fat soluble so its great for going into the brain to prevent more oxidative damage. GNC has a supplement called "Preventative Nutrition Brain Health Formula"

That has a lot of the ingredients already in there. Magnesium is also important because it supports many neurological functions. Take an amino acid blend such as "Optimum Nutrition Superior Amino 2222 tabs"
Before bed because your brain creates neurotransmitters while you sleep so if you have them ready to go they'll replace them faster. Hope this helps! Any questions do not hesitate to ask I love researching!!!

SINCE THIS IS MY FIRST POST MESSAGE ME FOR TIPS AND ADVICE OR ANY QUESTIONS. I HAVE A LOT OF KNOWLEDGE ABOUT THIS STUFF AND WANT TO SHARE IT!!!

Post Quality Evaluations:

Please do not use SWIM https://www.drugs-forum.com/forum/showthread.php?t=197306

Excellent info!

This is really great info from a very reliable source. If not already mentioned, perhaps this should be added to meth medicine cabinet post?