Clay Buchholz pitched seven shutout innings to earn his major league-leading sixth win, Mike Napoli hit two of Boston's five home runs and the Red Sox routed the Toronto Blue Jays 10-1 on Wednesday night.

Stephen Drew hit a two-run shot in the second inning and Napoli went back-to-back with Daniel Nava in the fourth as the Red Sox won their majors-best 19th game and improved to 8-3 away from home, the best road record in the big leagues.

Napoli hit a solo shot into the second deck in center in the fourth and followed up with a three-run shot into the third deck in the seventh. Napoli, who also doubled in the ninth, has six home runs this season and leads the majors with 21 extra-base hits.

Buchholz (6-0) allowed two hits, walked three and struck out eight, improving to 7-0 in his past eight starts at Toronto. The right-hander lowered his ERA to an AL-best 1.01. Only St. Louis Cardinals right-hander Jake Westbrook (0.98) is better.

For Buchholz, it's the best beginning to a season by a Red Sox pitcher since Josh Beckett opened 7-0 in his first seven starts of 2007.

Alex Wilson got two outs in the eighth and Clayton Mortensen worked the final 1 1-3 innings for Boston.

The Blue Jays didn't get a runner past first base until Adam Lind walked and went to third on Melky Cabrera's single in the seventh. But Cabrera was thrown out trying to stretch his hit into a double before J.P. Arencibia struck out to end the inning.

After rallying to beat the Red Sox 9-7 in Tuesday's series opener, the last-place Blue Jays couldn't maintain any momentum, losing for the seventh time in nine games. Toronto has won consecutive games just once this season, April 12 and 13 at Kansas City.Blue Jays left-hander Mark Buehrle (1-2) surrendered three home runs for the second straight start and has allowed nine home runs in six starts this season. Buehrle gave up five runs and seven hits in 6 2-3 innings. He walked a season-high three and struck out one.

Three of Boston's first five outs were fly balls to the warning track. After Middlebrooks was hit by a pitch in the second, Drew made sure he cleared the wall by homering into the second deck in right, his first.

Napoli led off the fourth with a drive to center, his fifth, and Nava followed with a shot to left, his fifth. It was the fourth time this season the Red Sox have hit consecutive homers, and the second time they've done it against Toronto.

Boston chased Buehrle and broke the game open with a four-run seventh, doing all its damage with two outs. Esmil Rogers came on after a two-out walk to Jonny Gomes, who went to third on Dustin Pedroia's single and scored on a wild pitch. Ortiz was intentionally walked before Napoli clubbed his second home run of the night. For Napoli, it was the 11th multihomer game of his career and his first this season.

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Ortiz went 1 for 3 and has hit safely in all 10 games since coming off the disabled list.

Pinch hitting for Ortiz, Mike Carp hit a solo drive off Justin Germano in the ninth, his second. Napoli followed with a double and scored on Nava's single to center.

Brett Lawrie drove in Toronto's only run with an RBI triple off Wilson in the eighth.

NOTES: Blue Jays RHP R.A. Dickey has been diagnosed with mild inflammation in his neck and back following an MRI, and will get an extra day of rest before his next start, Saturday against Seattle. RHP Josh Johnson, who was scratched from his start last Friday with tightness in his right triceps, will return to the rotation Friday. ... Boston OF Shane Victorino (back) swung the bat for a second straight day and remains on track to take full batting practice Thursday. Victorino, who has not played since Apr. 24, hopes to return for Friday's game at Texas. Victorino has missed six straight games.