The couple -- whose quest to start a family was first chronicled on their reality show, Giuliana & Bill, during Season 2 -- fought back tears as they discussed the miscarriage Giuliana suffered while undergoing IVF treatments six months ago.

"About eight weeks in we went for a routine ultrasound and the nurse looked very concerned," Giuliana, 36, recalled. "She brought in the doctor and he looked concerned."

The Rancics were the instructed to wait in the doctor's office while he reviewed their case more thoroughly.

"When we were in there he came in, and we just knew that something wrong. And I broke down and I couldn't believe it," Giuliana said. "Our pregnancy was going beautifully. We had told our family. We had confided in people and told them, and we were just thrilled."

"It was several months of guilt and sadness," Giuliana said. "And finally, I think we just came together and we said, 'There's got to be a bigger plan here, right? There has got to be a reason.'"

Giuliana and Bill just launched a national iPSA campaign with RESOLVE: The National Infertility Association, and EMD Serono to get the word out that if couples are having trouble getting pregnant, they should see a fertility specialist as soon as possible to get evaluated and learn about fertility.