Viruses Services

GeneCust offers an improved technology to simplify and accelerate the construction of adenoviral vectors, which offer many advantages to investigators who study gene expression or gene silencing in mammalian systems. Adenoviruses have a strong safety record and recombinant adenoviral vectors have been useful tools for gene function studies as well as for human gene therapy. Recombinant adenoviruses that cannot replicate are attractive vectors for gene delivery for several reasons:

they infect many types of mammalian cells with high efficiency

they do not disrupt the genome of the host cell but remain in the nucleus as episomal DNA

they provide transient, high level gene expression

they are suitable for both in vitro and in vivo applications

GeneCust has been providing the high quality services and technical supports to researchers in academic institutes, pharmaceutical and biotech industrials since 2002. Currently, GeneCust is providing a complete line of adenoviral services.

Lentiviral and Retroviral services

Delivery of genes by lentivirus has been well established and is currently widely used due to several advantages: Lentiviruses can accommodate long sequences and seem to be non-immunogenic due to the lack of viral coding sequences transfer; the lentiviruses are able to transduce non-dividing cells; and the products can be stably expressed due to integration into the cell chromosome.

GeneCust provides the lentiviral and retroviral services for research applications.

Adeno-associated Virus Services

Adeno-associated virus (AAV) vectors are currently among the most frequently used viral vectors for gene therapy. AAV is an ideal virus to use as the vehicle for gene transfer because:

AAV is a simple, easily manipulated virus

AAV can deliver genes to both dividing and non-dividing cells

AAV can deliver genes to a wide variety of tissue types from muscle to brain

AAV has never been shown to cause disease

AAV elicits only weak immunologic responses

AAV allows expression of proteins in the host cells for long periods of time