Based on its similarity to other proteins Zinc finger and BTB domain-containing, the protein encoded by ZBTB7A is believed to play a key role in the instruction of early lymphoid progenitors to develop into B lineage by repressing T-cell instructive Notch signals and/or to efficiently abrogate E2F1-dependent CDKN2A transactivation/de-repression. Expressed in medullary epithelial cells and Hassle's corpuscles in WT thymus and in the squamous epithelium as well as the germinal center lymphocytes in tonsils. The product of ZBTB7A is up-regulated in a subset of lymphomas, as well as in a subset of breast, lung, colon, prostate and bladder carcinomas (at protein level). ZBTB7A has been shown to interact with BCL6.

Rabbit anti Human pokemon antibody detects a band of 75 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.

Target Species

Human

Western Blotting

Rabbit anti pokemon detects a band of approximately 75 kDa in HEK293 cell lysates

Rabbit anti pokemon detects a band of approximately 75 kDa in HEK293 cell lysates

Product Form

Purified IgG - liquid

Purified IgG - liquid

Preparation

Rabbit polyclonal antibody purified by affinity chromatography

20μl Rabbit polyclonal antibody purified by affinity chromatography

Buffer Solution

Phosphate buffered saline

Phosphate buffered saline

Preservative Stabilisers

0.09% Sodium Azide2% Sucrose

0.09% Sodium Azide2% Sucrose

Immunogen

Synthetic peptide encompassing part of the N terminal region of human pokemon

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.

Application Name

Yes

No

Min Dilution

Max Dilution

Western Blotting

1/1000

Application Name

Yes

No

Min Dilution

Max Dilution

Western Blotting

1/1000

PrecisionAb antibodies have been extensively validated for the western blot application. The antibody has been validated at the suggested dilution. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependant on sample type.