Abstract: The United States, Japan and Germany are the world's scientific and technological powers and economic powers. Their governments have long paid attention to the cooperation of industry, university and research institute to promote the transformation of scientific and technological achievements into real productivity. After several years of practicing, each of the three countries gradually formed its own unique cooperative model that suits its own national conditions. Based on the analysis of the main models of the three countries, some suggestions on promoting the development of our country's industry-university-research institute cooperations are given.