Mass Spectrometry

Mass spectrometry (MS) is an analytical technique used across several different scientific disciplines to identify unknown compounds within a sample and determine the chemical structure of a substance.

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What's New

Waters Corporation recently celebrated the official opening of its new, custom-built mass spectrometry headquarters in Wilmslow, UK, confirming the company's commitment to innovation and the expanded usage of mass spectrometry.

University of Bath, UK, recently celebrated the official opening of its new Chemical Characterisation and Analysis Facility (CCAF). The facility showcased an influx of new analytical equipment in the area of Mass Spectrometry, NMR Spectroscopy and X-ray Crystallography.

Discover SelectScience Webinars

In this webinar, Terri Christison and Dr. Junhua Wang will describe ion chromatography, coupled with high resolution accurate mass spectrometry (IC-HR/AM) using orbitrap MS technology. This technology provides a solution to many of the analytical challenges associated with differentiating isobaric metabolites.

This webinar will focus on fast, accurate, and sensitive small molecule impurity and drug metabolite identification through the use of new workflows based on ultra-high resolution mass spectrometry and statistical profiling. Case studies will be presented showing rapid, high-throughput analysis relying on molecular identification; allowing for the elimination of the LC separation step in small molecule analysis.

How to Choose a Mass Spectrometer

Buying a new mass spectrometer is a huge investment, and with the variety and diversity of mass spectrometers on the market, it is important to make sure you purchase the instrument that best fits your needs and will bring a good return for your investment.

This buying guide provides you with information to help you make the right decision when choosing new mass spectrometry equipment. Learn about common mass spectrometer configurations, key applications areas, different factors to consider for purchase, as well as current and future trends in mass spectrometry. Throughout the Guide, you will find Buying Guide Tips, which are practical suggestions that might help in your pursuit for the most suitable mass spectrometer. The Guide ends with a Glossary of acronyms that are mentioned in the text and some common terms in mass spectrometry that could be useful, especially for those who are new to the technology.

What's New

Waters Corporation recently celebrated the official opening of its new, custom-built mass spectrometry headquarters in Wilmslow, UK, confirming the company's commitment to innovation and the expanded usage of mass spectrometry.

University of Bath, UK, recently celebrated the official opening of its new Chemical Characterisation and Analysis Facility (CCAF). The facility showcased an influx of new analytical equipment in the area of Mass Spectrometry, NMR Spectroscopy and X-ray Crystallography.

With the World Cup in Brazil capturing the eyes of the world and the start of the Tour de France this week, SelectScience is looking at the slightly controversial performance-enhancing effects of caffeine.

How to Choose a Mass Spectrometer

Buying a new mass spectrometer is a huge investment, and with the variety and diversity of mass spectrometers on the market, it is important to make sure you purchase the instrument that best fits your needs and will bring a good return for your investment.

This buying guide provides you with information to help you make the right decision when choosing new mass spectrometry equipment. Learn about common mass spectrometer configurations, key applications areas, different factors to consider for purchase, as well as current and future trends in mass spectrometry. Throughout the Guide, you will find Buying Guide Tips, which are practical suggestions that might help in your pursuit for the most suitable mass spectrometer. The Guide ends with a Glossary of acronyms that are mentioned in the text and some common terms in mass spectrometry that could be useful, especially for those who are new to the technology.

Mass Spectrometry Applications and Methods

This application note describes the use of the ACQUITY QDa module, a small but robust, simple-to-use mass detector, to quantitate non-chromophoric memantine HCl, a drug commonly used to treat dementia often associated with Alzheimer’s disease.

This poster describes the development of the Acrodisc MS syringe filters. The cleanliness of filter effluents using Acrodisc MS syringe filters and two commercially available alternative syringe filters are compared by evaluating the presence of extractable/leachable compounds in the filter effluents under the same filtration and LC/ESI/MS analytical test conditions.

Crude oil samples can be distinguished at the molecular level by LDI ultra-high resolution mass spectrometry. In this application note, LDI-FT-ICR measurements provide the reproducibility required for efficient PCA characterization. Crude oils are best separated in PCA scoring plots using average mass lists and logarithmic scaling.

This white paper reviews the XS Collision Cell as the latest technological advance that delivers increased sensitivity and allows the Q-Tof to match the quantitative performance of many tandem quadrupole instruments without compromising mass resolution.

Videos

Thermo Fisher Scientific showcased 3 new Class I medical devices at AACC 2014. Watch this video to learn more about the HPLC, LC-MS and LC-MS software that have been designed to be components of laboratory-developed tests for analyzing patient samples.

Prof. Nicholson describes personalized medicine and how delivering the correct treatment for the right individual, based on their genes and environment, could be the future of healthcare. The use of mass spectrometry and NMR spectroscopy enables an overview of hundreds of thousands of metabolites in a single analytical run covering a large number of physiological and metabolic processes. This gives an insight as to how one might respond to treatment. Personalized medicine has the opportunity to save lives, shorten journeys, and save money.

Dr Matthew Lewis describes how the MRC-NIHR Phenome Centre investigates what makes people metabolically different. By analyzing large cohorts of patients and performing epidemiological studies, an insight into the understanding of human metabolism can be achieved. NMR and UPLC mass spectrometry are used with a combination of different chromatography methods to gain accurate analysis of small molecules in human samples.

Watch this video to learn how mass spectrometry is used for metabolomics research. Elizabeth Want, PhD., Imperial College, explains her research involving the development and optimization of mass spectroscopy based metabolite profiling. Solutions provided by Waters have allowed for higher throughput, increased sensitivity, and less time required.

Webinars

In this webinar, Prof. L. C. Cameron will describe a novel, sportomics approach to studying exercise-induced changes in the human metabolome. Discover new solutions to analyzing small data sets, and discover how the sportomics approach can bridge the gap between bench top and clinical science, furthering our understanding of hypermetabolic disease states.

Latest Technology News

Waters® Corporation has announced that the Chinese Food and Drug Administration (CFDA) approved the registration of the ACQUITY UPLC® TQD system for legal promotion and sale in China as a medical device for routine diagnostic applications and neonatal metabolites diseases screening.

AB SCIEX, a global leader in analytical technologies, has confirmed its commitment to support the diagnostic market with the unveiling of the Triple Quad™ 4500MD and QTRAP® 4500MD LC/MS/MS systems under its SCIEX Diagnostics brand. The systems were showcased at the AACC 2014 Annual Meeting and Clinical Lab Expo last week.

Waters Corporation recently announced the acquisition of Rapid Evaporative Ionization Mass Spectrometry (REIMS) technology from MediMass Ltd. The REIMS technology represents substantially all of the assets of MediMass and includes patent applications, software, databases and REIMS expertise.

Clinical laboratories around the world are focused on reporting quality and truth in results, and LC-MS is becoming the analytical technique of choice. Accurate test results are necessary for clinical research and discovery, as well as routine diagnostic testing.