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About NUI Galway

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Prof John Kelly B.Sc., Ph.D.

Contact Details

Biography:

My current position is as a Senior Lecturer in the Department of Pharmacology and Therapeutics, NUI, Galway. I have spent over 25 years involved in pharmacological and toxicological research, 8 of which have been in industry.

Research Interests

My research has centred on preclinical animal models of depression, most particularly investigating the olfactory bulbectomized and whether this myriad of changes associated with this model can be attenuated by chronic treatment with antidepressants, both established and novel treatments. This research has demonstrated how valuable the integrated approach can be in ascertaining interactions between behavioural, physiological, neurochemical and immune changes. A similar approach has been taken with other animal models under my direction, such as the Forced Swim Test and lipopolysaccharide models. This research has resulted in over 100 peer-reviewed publications. More recently, I have become interested in exploring the integrative nature of my research in the realms of antinociceptive properties of psychotropic drugs.

De Souza, I., Kelly, J.P., Harkin, A.J. and Leonard, B.E. (1997) 'An appraisal of the pharmacological and toxicological effects of a single oral administration of 3,4-methylenedioxymethamphetamine (MDMA) in the rat'. Pharmacology And Toxicology, 80 :207-210. [Details]

Kelly, JP,Leonard, BE (1999) 'An investigation of the antidepressant properties of lofepramine and its desmethylated metabolites in the forced swim and olfactory bulbectomized rat models of depression'. European Neuropsychopharmacology, 9 :101-105. [Details]

Dredge, K., Connor, T.J., Kelly, J.P. and Leonard, B.E. (1999) 'Differential effect of a single high dose of the tricyclic antidepressant imipramine on interleukin-1 and tumor necrosis factor-secretion following an in vivo lipopolysaccharide challenge in rats'. International Journal Of Immunopharmacology, 21 :663-673. [Details]

Other Journals

Redmond, A.M., Kelly, J.P. and Leonard, B.E. (1994) 'Effect of paroxetine and fluvoxamine on behavioural changes in a number of paradigms in the olfactory bulbectomized rat model of depression' Journal of Serotonin Research 3 :199-205. [Details]