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The study was approved by the Medical Ethics Committee of VU University Medical Center (2013/10). All patients provided written informed consent.

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Not applicable.

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HV receives grants from Roche, Vitromics Healthcare System, Novartis, Immunovo B.V., Amgen, non-financial support from Pfizer, and honoraria from Boehringer Ingelheim. These resources were all received outside the submitted work. The other authors declare no competing interests.

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