As indicated in the foreword by Dr. W. Allen Daley, this was the last manuscript completed by Dr. Burke before his death. In such a small volume it is almost impossible to do more than touch the most salient points in the treatment of syphilis. In fact the author constantly refers the reader to his larger volume "Venereal Diseases" (London, H. K. Lewis & Co., Ltd., 1940). He still believes in the use of Zittmann's decoction in certain cases of malignant syphilis "in refractory, relapsing and drug inert patients." He thinks the effects are due to the presence of two saponins in the sarsaparilla root in the compound. He prefers liposoluble bismuth and likes no oral bismuth compounds. He thinks there is a place for acetarsol (acetarsone) for adults (sailors and travelers, long distance lorry drivers and others). He considers mapharside (mapharsen) inferior and "causative of disquietingly high incidence of