Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

Details

Applications

Approved:

ELISA

Specificity and Use

Immunogen:

OS9 antibody was raised against a C-terminal synthetic peptide made to isoform 1 of the human OS9 protein sequence (between residues 600-667). There are 3 isoforms of this protein. The immunogen used for both of these antibodies is conserved in isoforms 1, 2, and 3 of the human OS9 protein.

Epitope:

C-Terminus

Specificity:

The specificity of this antibody is unknown. Species cross-reactivity: Species reactivity of this antibody has not been determined. There is 100% identity/homology of the immunogen with the human OS9 protein. There is 94% homology of the immunogen with the mouse and rat OS9 proteins.

Description: Lectin which functions in endoplasmic reticulum (ER) quality control and ER-associated degradation (ERAD). May bind terminally misfolded non-glycosylated proteins as well as improperly folded glycoproteins, retain them in the ER, and possibly transfer them to the ubiquitination machinery and promote their degradation. Possible targets include TRPV4.