After the prophet Elijah defeated the priests of Baal and then fled Jezebel's wrath, The Lord came to him on Mount Horeb. He told him to anoint new kings of Syria and Israel. He also commanded Elijah to anoint "Elisha the son of Shaphat of Abel-meholah, (1 Kings 19:16)" a member of the tribe of Issachar, to replace Elijah as the prophet of God to the northern kingdom of Israel ca. 849-786 B.C.

During Elijah's final days on earth, Elisha refused to leave his mentor's side. Elisha asked Elijah to grant him a final blessing, saying, "Please let there be a double portion of your spirit on me. (2 Kings 2:9)" Once he saw the elder prophet taken up into heaven, Elisha took up Elijah's mantle and assumed the prophetic office (2 Kings 2:1-14).

Like Elijah, Elisha played an active role in political affairs. He also performed many miracles, foreshadowing the miracles of God's own son. Among these, he cured the Syrian army commander Naaman of his leprosy (2 Kings 5:1-27), fed a multitude of hungry men (2 Kings 4:42-44), and restored life to the son of a Shunammite woman (4:8-37). A vocal opponent of Baal worship, Elisha lived up to his name, which means "my God is salvation."