Translocation/Dual Fusion Probe

XL PML/RARA

Translocation/Dual Fusion Probe

Description

This product has been replaced by XL t(15;17) DF. Order Number D-5086-100-OG

Clinical Details

Several recurrent balanced translocations and inversions, and their variants, are recognized in the WHO category acute myeloid leukemia (AML) with recurrent genetic abnormalities. Furthermore, several cytogenetic abnormalities are considered sufficient to establish the WHO diagnosis of AML with myelodysplasia-related features when 20% or more blood or marrow blasts are present.

AML M3 and AML M3v are characterized by a reciprocal translocation between the long arm of chromosome 15 and the long arm of chromosome 17. This translocation leads to a rearrangement of the PML-gene situated on chromosomal band 15q24 and the RARA-gene situated on band 17q21. The PML-RARA-rearrangement has gained major clinical importance as combining ´all transretinoic acid´ and conventional anthracy-cline-cytarabin based chemotherapy has improved the prognosis in this subgroup of AML dramatically.

Clinical Applications

Acute Myelogenous Leukemia (AML)

Images

XL PML/RARA was hybridized to lymphocytes. Two normal interphase cells are shown.

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Related News

Fluorescence in situ hybridization has become an essential detection assay in today´s routine diagnostics. However, long hybridization times of many hours to overnight are still a restrictive factor. We have refined the production process of our FISH probes to reduce background and artefacts and to improve the signal to noise ratio, particularly in short-time hybridization. Since mid-2015, one hour hybridization on lymphocytes is an integral part of quality control for all XCyting locus-specific probes at our manufacturing facility.

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MetaSystems Probes is proud to announce the new probes catalogue 2019/2020 with many new products, more information, and a brand new design. A PDF file of the new catalogue is available for download here on the download section of the MetaSystems Probes web site.

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