drug-drug interaction

drug-drug interaction

a modification of the effect of a drug when administered with another drug. The effect may be an increase or a decrease in the action of either substance, or it may be an adverse effect that is not normally associated with either drug. The particular interaction may be the result of a chemical-physical incompatibility of the two drugs or a change in the rate of absorption or the quantity absorbed in the body, the binding ability of either drug, or an alteration in the ability of receptor sites and cell membranes to bind either drug. Most adverse drug-drug interactions are either pharmacodynamic or pharmacokinetic in nature.

interaction

(int?er-ak'shon) [ inter- + action]

Alternating, reciprocating, or mutual influence or effect.

dielectric interaction

Determination of the quantity of the electrical polarity or dipole moment of a molecule.

drug interaction

, drug-drug interaction

The combined effect of drugs taken concurrently. The result may be antagonism or synergism and may be lethal in some cases. It is important for the patient, pharmacist, physician, and nurse to be aware of the potential interaction of drugs that are prescribed as well as those that the patient may be self-administering.

Many patients, esp. the elderly, may take several medicines each day. The chances of developing an undesired drug interaction increase rapidly with the number of drugs used.

food and drug interactions

The effect of nutrients on the absorption, distribution, metabolism or excretion of medications. For example, alkaloids in potatoes may influence the effects of anesthetics; excess intake of vegetables rich in vitamin K may interfere with the action of anticoagulants; prolonged use of antacids may cause phosphate depletion; consumption of grapefruits or grapefruit juice may influence the half-life of some antiretroviral drugs.

patient-ventilator interaction

The complex link between a patient's neurologically mediated control of breathing (and the elasticity and resistance of his or her airways) and the pressures and volumes of gases injected into the patient by a mechanical ventilator.

photoelectric interaction

The absorption of a photon by matter from its source of emission, producing a photoelectron and a K shell vacancy. The K shell vacancy is then filled by a cascade of electrons, each of which produces a characteristic photon. In clinical radiology, photoelectric absorption causes image contrast and increases the patient's exposure to scattered radiation.

drug interaction

, drug-drug interaction

The combined effect of drugs taken concurrently. The result may be antagonism or synergism and may be lethal in some cases. It is important for the patient, pharmacist, physician, and nurse to be aware of the potential interaction of drugs that are prescribed as well as those that the patient may be self-administering.

Many patients, esp. the elderly, may take several medicines each day. The chances of developing an undesired drug interaction increase rapidly with the number of drugs used.

An important finding is that people starting treatment with the integrase inhibitor Isentress ran a much lower risk of drug-drug interactions than did people starting treatment with a PI (such as Reyataz or Prezista) or an NNRTI (such as Sustiva or Viramune).

Biliary secretion from the liver is of particular interest to researchers who seek to understand how drugs will affect each other because it is an important first-pass and systemic clearance route for many drugs and the basis for many drug-drug interactions.

In an effort to save effort, time, money and lives, these ten articles address the science, practice and regulatory agency positions on drug-drug interactions during the evaluation phase of the drug discovery process.

in 1992, the newsletter has an international audience of psychiatrists, psychologists, and psychiatric nurses "who rely on the montly publication to alert them to new medications, potential side effects and drug-drug interactions," said publisher Betty Rawls Lang.

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