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The authors acknowledge the support of the Chao Family Comprehensive Cancer Center Transgenic Mouse Facility Shared Resource, supported by the National Cancer Institute of the National Institutes of Health under award number P30CA062203. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

The UC Irvine Transgenic Mouse Facility (TMF) is a core facility that provides services on a recharge basis for making, breeding, genotyping, importing, and preserving genetically-modified mice and embryonic stem cells. In addition to academic clients at UCI, we also service academic investigators at several other sister UC-campuses and numerous other universities throughout the USA as well as providing these services to commercial clients. The TMF's research associates have a combined 130 years of experience in generation of genetically engineered mice. Our experience can be your advantage.

"CRISPR" Cas9/gRNA genome editing services

In certain cases CRISPR Cas9/gRNA mediated gene editing can accelerate projects to modify the mouse genome. As of March 2019, the TMF has successfully conducted 72 independent projects to modify the mouse genome via use of Cas9/gRNA, many of which involved use of IDT's ssODN or MegaMers, with 37 more currently in progress. See the Cas9/gRNA Mediated Genome Engineering Services page for details.