With the common efforts of its scientists, Creative Biolabs successfully released Immune Antibody Library Construction System by Phage Display Technology.

Based on years of experience in phage display technology, Creative Biolabs now is able to provide services for the construction and screening of immune antibody library.

With years of research and development in the past decades, phage display has been a powerful technology to display millions or even billions of different peptides or proteins. It is now a common choice for the studies of protein-protein, protein-peptide and protein-DNA interactions. Among all the applications of phage display technology, one of the most successful ones is the isolation of monoclonal antibodies utilizing large capacity phage antibody libraries.

Thanks to the rapid development of this technology, it has become a reliable tool for the production of monoclonal antibody with high specificity and affinity.

“Compared with conventional hybridoma technology, the generation of immune antibody libraries is not limited by the requirement of fusion partners. This expands the possibility to develop monoclonal antibodies from a much broader range of species”, said Dr. Monika Müller, Scientific Officer of Creative Biolabs.

Generally, the phage-displayed immune antibody libraries are constructed in scFv and Fab format, and the antibody gene repertoire is created from the immunoglobulin gene of either spleen B cells for immunized animals or peripheral blood B cells for immunized donors. Theoretically, on the basis of appropriate genome information, phage display technology has the potential to construct antibody libraries for every species and develop the corresponding monoclonal antibodies.

Scientists from Creative Biolabs are confident in generating antibody libraries with a diversity of 108 to1010, which can meet the needs of the vast majority of research. Except for the regular antibody libraries of experimental animals, Creative Biolabs is also able to generate a series of antibody libraries from other species, such as human, guinea pig, shark and alligator.