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Program Snapshot

The Common Fund’s Library of Integrated Network-based Cellular Signatures (LINCS) program aims to develop a “library” of molecular signatures that describes how different types of cells respond to a variety of perturbing agents. The pilot phase of the program was completed in fiscal year 2013 and focused on the following activities:

Large-scale production of perturbation-induced molecular and cellular signatures

Creation of a database, common data standards and public user interface for accessing the data

Computational tool development and integrative data analyses

Development of new cost-effective, molecular and cellular phenotypic assays

Integration of existing datasets into LINCS

Furthermore, as of October 2013 (fiscal year 2014), continuation of the program was implemented to capitalize on the pilot phase. This new focused stage of the program supports LINCS Data and Signature Analysis Centers and coordinates with the NIH Big Data to Knowledge (BD2K) program.

Program Highlights

LINCS Data Science Research Webinars. Want to learn more about the LINCS data and how you can use them in your research? Join the LINCS Data Science Research Webinars held on select Tuesdays at 3:00 PM Eastern Time. See upcoming webinars and view archived webinars.

Request for Applications: BD2K-LINCS Data Coordination and Integration Center External Data Science Research Projects. The BD2K-LINCS Data Coordination and Integration Center (DCIC) is soliciting applications from the scientific community for data science research collaborations with the DCIC that focus on mining and integrating data generated by the LINCS program for new scientific discovery. The overarching goal of this solicitation is to maximize the value of LINCS data and transform it into new knowledge. The DCIC, via a subcontract, will support collaboration projects with a budget limit of $130K in total costs per year for up to two years. Applications are Due September 1, 2015.Learn how to apply.

Grants for Second Phase of LINCS Program Awarded. After a successful 3-year pilot project, the NIH announces $64 million in awards to establish 6 LINCS Data and Signature Generating Centers. Read the press release.

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ACCESS THE LINCS PORTAL The LINCS portal is a source of information for the research community and general public about the LINCS project. The portal contains details about the assays, cell types, and perturbagens currently part of the library, as well as links to participating sites, the data releases from the sites, and software that can be used for analyzing the data. Click on the image below to get started.