The 11 papers in this collection review the TNF-cascade signaling system, the effect of TNF-alpha in isolated limb perfusion treatment of cancers, and TNF-alpha neutralizing therapies for Crohn's disease.

In the one-quarter of patients who have a recurrence of melanoma after primary treatment, a variety of treatment options are used, including wide local excision, therapeutic lymph node dissection, isolated limb perfusion, radiation therapy, and various systemic therapies.

Although the standard of practice in most institutions is to assess limb perfusion through physical examination and clinical judgment, development of quantitative measurements of perfusion remains a desirable objective because perfusion determines the degree and progression of the pathological process that can lead to amputation.

As she was suffering from recurring melanomas, Mrs Ogden faced the choice of travelling to Glasgow for isolated limb perfusion - or becoming the first to try a new technique brought from Australia to Britain.

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