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{\*\bkmkstart filing_1}{\*\bkmkend filing_1}{\*\bkmkstart doc_1_1}{\*\bkmkend doc_1_1}\par\pard\plain\cf1\f51\fs16\ql \~\par\pard\plain\cf1\f51\fs28\b\qc UNITED STATES
\par\pard\plain\fs16\pard\plain\cf1\f51\fs28\b\qc SECURITIES AND EXCHANGE COMMISSION\par\pard\plain\cf1\f51\fs20\b\qc Washington, D.C. 20549\par\pard\plain\cf1\f51\fs20\b\qc \~\par\pard\plain\cf1\f51\fs28\b\qc SCHEDULE 14A\par\pard\plain\cf1\f51\fs20\qc \~\par\pard\plain\cf1\f51\fs20\b\qc Proxy Statement Pursuant to Section 14(a) of
\par\pard\plain\fs16\pard\plain\cf1\f51\fs20\b\qc the Securities Exchange Act of 1934 (Amendment No. \~\~\~\~)\par\pard\plain\cf1\f51\fs16\ql \~
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\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\ql FOR IMMEDIATE RELEASE\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\qc Ironwood Pharmaceuticals Sends Letter to Shareholders\par\pard\plain\cf1\f51\fs20\b\qc Highlighting Director Nominees\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\i\qc \u8212? Urges Shareholders to Vote \u8220?FOR\u8221? the Ironwood Director Nominees
\par\pard\plain\fs16\pard\plain\cf1\f51\fs20\i\qc on the WHITE Proxy Card \u8212?\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\ql CAMBRIDGE, Mass., May\~14, 2018 \u8212? Ironwood Pharmaceuticals,\~Inc. (NASDAQ: IRWD), a commercial biotech\plain\cf1\f51\fs20\ql company, today announced that it has mailed a letter to shareholders highlighting the experience and personal perspectives of the\plain\cf1\f51\fs20\ql company\u8217?s director nominees: Lawrence Olanoff, M.D., Ph.D., Amy Schulman and Douglas Williams, Ph.D.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\ql The Ironwood Board of Directors strongly recommends that shareholders vote on the WHITE proxy card \u8220?FOR\u8221?\plain\cf1\f51\fs20\ql Ironwood\u8217?s experienced, diverse and independent nominees. Ironwood\u8217?s letter to shareholders and other materials\plain\cf1\f51\fs20\ql regarding the Board\u8217?s recommendation for the 2018 Annual Meeting can be found at www.ironwoodannualmeeting.com.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\ql The full text of the letter follows:\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\ql Dear Fellow Shareholder,\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\ql Over the past 20 years,\~Ironwood has grown into a strong commercial biotech company that is bringing important medicines to\plain\cf1\f51\fs20\ql millions of patients, advancing a robust pipeline of innovative drug candidates, and cultivating a team of talented and passionate\plain\cf1\f51\fs20\ql employees. We are taking action designed to realize the value we are generating from accelerating revenue growth and\plain\cf1\f51\fs20\ql advancement of our promising drug candidates through our recently announced intent to separate into two independent, publicly\plain\cf1\f51\fs20\ql traded companies (Ironwood and \u8220?R&D Co.\u8221?).\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\ql This is an exciting and critical period for Ironwood as we work to complete the separation, which is now underway. Importantly,\plain\cf1\f51\fs20\ql we believe we have the right Board in place to oversee that value creation opportunity and effectively execute this process with\plain\cf1\f51\fs20\ql urgency and stability. Your Board:\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\li550\fi-264\cf1\f53\fs20\ql ·\plain\li550\cf1\f51\fs6\ql \~\~\~\~\~\~\~\~\~\~\~\~\~\~\~\~\~\plain\li550\cf1\f51\fs20\b\ql Regularly explores opportunities to enhance shareholder value,\plain\li550\cf1\f51\fs20\ql demonstrated by our comprehensive review of\plain\li550\cf1\f51\fs20\ql strategic options that began last fall and which led to the decision to separate Ironwood into two independent, publicly\plain\li550\cf1\f51\fs20\ql traded companies.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par
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\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\li550\fi-264\cf1\f53\fs20\ql ·\plain\li550\cf1\f51\fs6\ql \~\~\~\~\~\~\~\~\~\~\~\~\~\~\~\~\~\plain\li550\cf1\f51\fs20\b\ql Seeks and acts on ideas from our fellow shareholders\plain\li550\cf1\f51\fs20\ql and outside advisors, helping to inform decisions as we evolve\plain\li550\cf1\f51\fs20\ql and execute against our strategy. In fact, shareholder input helped inform the decision we made to separate.\par\pard\plain\li550\fi-264\cf1\f53\fs20\ql ·\plain\li550\cf1\f51\fs6\ql \~\~\~\~\~\~\~\~\~\~\~\~\~\~\~\~\~\plain\li550\cf1\f51\fs20\b\ql Has the benefit of fresh perspectives\plain\li550\cf1\f51\fs20\ql , with a group of directors that comprise a diverse set of backgrounds, expertise,\plain\li550\cf1\f51\fs20\ql and tenure (including six new independent directors added since 2013).\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\ql At our Annual Meeting on May\~31, 2018, your Board has three highly qualified independent directors up for election: Lawrence\plain\cf1\f51\fs20\ql Olanoff, M.D., Ph.D., Amy Schulman, and Douglas Williams, Ph.D. Ironwood\u8217?s director nominees, each of whom joined\plain\cf1\f51\fs20\ql the Board within the last four years, offer an expansive skill set and are active in driving the company\u8217?s long-term\plain\cf1\f51\fs20\ql strategy. All three directors are world-renowned leaders in their chosen specialty. They have each served as C-level executives\plain\cf1\f51\fs20\ql in large global biopharmaceutical companies and as CEOs of smaller, entrepreneurial biotech companies.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\ql In this letter, we invite you to hear from Larry, Amy and Doug about their experience and why they believe Ironwood is on the\plain\cf1\f51\fs20\ql right path to deliver substantial value creation.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\ql We are excited about the opportunities ahead for Ironwood, and thank you for your continued support.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\ql Sincerely,\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\ql The Ironwood Board of Directors\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\qc To elect the Ironwood Board of Directors\u8217? nominees, we encourage you to vote today by telephone,\~Internet, or by\plain\cf1\f51\fs20\b\qc signing and dating the enclosed WHITE proxy card and returning it in the postage-paid envelope provided.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\qc 2{\*\bkmkstart pb_2_070149_3360_12252269}{\*\bkmkend pb_2_070149_3360_12252269}\par\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par
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\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\qc MEET THE IRONWOOD BOARD NOMINEES\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\ql Lawrence Olanoff, M.D., Ph.D.
\par\pard\plain\fs16\pard\plain\cf1\f51\fs20\b\ql Independent, Director since 2015\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\ql Medical University of South Carolina
\par\pard\plain\fs16\pard\plain\cf1\f51\fs20\ql Adjunct Professor and Special Advisor to President for Corporate Relations (2011 \u8211? Present)\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\ql Forest Laboratories, Inc.
\par\pard\plain\fs16\pard\plain\cf1\f51\fs20\ql COO (2006 \u8211? 2010)
\par\pard\plain\fs16\pard\plain\cf1\f51\fs20\ql EVP & Chief Scientific Officer (1995 \u8211? 2005)\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\ql Celsion Corporation
\par\pard\plain\fs16\pard\plain\cf1\f51\fs20\ql President & CEO (2005 \u8211? 2006)\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\ql Sandoz
\par\pard\plain\fs16\pard\plain\cf1\f51\fs20\ql SVP, Clinical R&D (1993 \u8211? 1995)\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\ql Professional Highlights\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\li264\cf1\f51\fs20\ql At Forest Labs, involved in negotiations of several partnerships and was integrally involved with the decision to sell to\plain\li264\cf1\f51\fs20\ql Actavis as a Forest Board member\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\li264\cf1\f51\fs20\ql Also while at Forest, led a group that obtained U.S. approval for a number of NDAs across range of therapeutic areas\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\li264\cf1\f51\fs20\ql Chairman of the Board of the Clinical Biotechnology Research Institute at Roper St. Francis Hospital\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\li264\cf1\f51\fs20\ql Board member of the Horizon Project and the Zucker Institute for Applied Neurosciences\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\li264\cf1\f51\fs20\ql Ex-officio director and former Board member of the MUSC Foundation for Research Development and former Board member\plain\li264\cf1\f51\fs20\ql of Celsion, Axovant Sciences and Forest Laboratories\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\ql Can you tell me more about the unique skillsets you bring to Ironwood?\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\ql I have led drug development for the majority of my career. On the clinical pharmacology side,\~I have a very good understanding\plain\cf1\f51\fs20\ql of the interface between drug discovery and drug development. Having led large drug development organizations in three\plain\cf1\f51\fs20\ql different companies,\~I also have a deep understanding of what makes projects successful. Getting a new drug approved is a major\plain\cf1\f51\fs20\ql endeavor, but it\u8217?s only a part of the process. You can have a great product and still fail in the commercial market, but you\plain\cf1\f51\fs20\ql can\u8217?t take a bad product and be successful in the commercial market. To achieve success, it\u8217?s critical to have the\plain\cf1\f51\fs20\ql ability to effectively manage the process between drug discovery and development and drug development and commercialization.\plain\cf1\f51\fs20\ql I also have significant experience in partnering as well as M&A. At Forest,\~I was involved in the negotiations of a number of\plain\cf1\f51\fs20\ql partnerships, and as a Forest Board member,\~I was involved in the company\u8217?s decision to sell to Actavis.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\ql I\u8217?ve always been impressed with Ironwood\u8217?s ability to achieve that critical balance. I was excited to join the\plain\cf1\f51\fs20\ql Ironwood Board in 2015, given that the directors have a unique blend of expertise and skillsets that are critical to both\plain\cf1\f51\fs20\ql commercial and R&D success. It\u8217?s an advantage we have over many other companies of Ironwood\u8217?s size.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\ql As someone with significant industry experience, could you describe why a separation is the best path forward for\plain\cf1\f51\fs20\b\ql Ironwood?\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\ql I\u8217?ve been an executive at three pharmaceutical companies over my 30-year career, and my experience has shown me that\plain\cf1\f51\fs20\ql the model for success in this industry has changed dramatically. Success in the market today requires a greater degree of focus,\plain\cf1\f51\fs20\ql and investors likewise look for companies that have a clear strategy and identifiable core competencies, whether that is in drug\plain\cf1\f51\fs20\ql discovery, development or commercialization. By separating the company into two more nimble, productive businesses with\plain\cf1\f51\fs20\ql strengthened competitive positions, we believe there is a unique opportunity to hone the models and focus on each\plain\cf1\f51\fs20\ql company\u8217?s specific attributes. The commercial company is expected to have products that provide a great deal of value for\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\qc 3{\*\bkmkstart pb_3_072653_35_12252269}{\*\bkmkend pb_3_072653_35_12252269}\par\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par
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\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\ql physicians and patients and to be well positioned for success. R&D Co. is expected to have a pipeline of innovative product\plain\cf1\f51\fs20\ql candidates in areas of significant unmet need. The strength of this pipeline is that it is not focused on developing one drug, but\plain\cf1\f51\fs20\ql on harvesting a technology platform built around a key biological mechanism, which we believe will allow it to efficiently\plain\cf1\f51\fs20\ql advance multiple drug candidates.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\ql As a member of the governance and nominating committee, how does Ironwood approach the vetting of director\plain\cf1\f51\fs20\b\ql candidates?\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\ql Out of all the companies I\u8217?ve been involved with,\~Ironwood has been the most deliberate in its assessment of Board\plain\cf1\f51\fs20\ql candidates. My own recruitment process spanned over several months, and I was interviewed by many directors. This is a very\plain\cf1\f51\fs20\ql thorough process that is both appropriate and necessary to ensure we are adding candidates that bring the right mix of\plain\cf1\f51\fs20\ql competencies and experiences, as well as the personal qualities to strengthen our collective decision-making needed for the\plain\cf1\f51\fs20\ql long-term success of the company. As a Board, we are happy to shake things up to get the best outcome for the company, and\plain\cf1\f51\fs20\ql we have proven our openness to adding several new directors that bring unique perspectives.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\ql Amy Schulman
\par\pard\plain\fs16\pard\plain\cf1\f51\fs20\b\ql Independent, Director since 2017\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\ql Lyndra
\par\pard\plain\fs16\pard\plain\cf1\f51\fs20\ql CEO\~& Co-Founder (2015 \u8211? Present)\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\ql Polaris Partners
\par\pard\plain\fs16\pard\plain\cf1\f51\fs20\ql Partner (2014 \u8211? Present)\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\ql Olivo Labs
\par\pard\plain\fs16\pard\plain\cf1\f51\fs20\ql CEO (2017 \u8211? Present)\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\ql Arsia Therapeutics
\par\pard\plain\fs16\pard\plain\cf1\f51\fs20\ql CEO (2014 \u8211? 2016)\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\ql Pfizer
\par\pard\plain\fs16\pard\plain\cf1\f51\fs20\ql EVP & GC (2008 \u8211? 2014)
\par\pard\plain\fs16\pard\plain\cf1\f51\fs20\ql Business Unit Leader for Consumer Healthcare Business (2012 \u8211? 2013)\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\ql DLA Piper
\par\pard\plain\fs16\pard\plain\cf1\f51\fs20\ql Partner (1997-2008)\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\ql Professional Highlights\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\li264\cf1\f51\fs20\ql Played instrumental role in Pfizer Nutrition\u8217?s sale to Nestle and spinning out Zoetis, as well as its acquisition of Wyeth\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\li264\cf1\f51\fs20\ql CEO of Lyndra and Olivo Labs\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\li264\cf1\f51\fs20\ql Board member of Arsanis and Alnylam Pharmaceuticals\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\li264\cf1\f51\fs20\ql Former Board member of Blue Buffalo Pet Products and BIND Therapeutics\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\ql You\u8217?ve served on the Ironwood Board for a year. What can you tell us about the Board\u8217?s priorities and how\plain\cf1\f51\fs20\b\ql strategic decisions are made?\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\ql The Board\u8217?s priorities are clear. They start with total shareholder return over the short-, medium- and long-term. We\plain\cf1\f51\fs20\ql certainly hold management accountable and spend a significant amount of time discussing management\u8217?s performance. We\plain\cf1\f51\fs20\ql look to ensure that both the management team and company are growing and developing and that the right talent is in place, both\plain\cf1\f51\fs20\ql at the Board and management level. In fact, we believe that the composition of the Board and assessing the leadership of the\plain\cf1\f51\fs20\ql company are two of the most critical decisions that a Board has to make. We continually look at ways to enhance value for\plain\cf1\f51\fs20\ql shareholders; closing the gap between what we believe the value potential of the company is relative to how the market values\plain\cf1\f51\fs20\ql Ironwood is a\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\qc 4{\*\bkmkstart pb_4_071720_1964_12252269}{\*\bkmkend pb_4_071720_1964_12252269}\par\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par
\page
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\ql top priority. The decision to embark on the separation is a prime example of this Board taking proactive action to address that\plain\cf1\f51\fs20\ql gap.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\ql While at Pfizer, you played an instrumental role in the sale of Pfizer Nutrition to Nestle, the Zoetis spin-off and the\plain\cf1\f51\fs20\b\ql acquisition of Wyeth. How did those experiences inform your decision-making process as the Board considered the intent\plain\cf1\f51\fs20\b\ql to separate Ironwood?\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\ql During my tenure at Pfizer,\~I developed broad M&A experience and skills. I also experienced firsthand the significant\plain\cf1\f51\fs20\ql opportunities that exist to unlock value, as evident from the sale of the Pfizer nutrition business to Nestle. During my time as\plain\cf1\f51\fs20\ql general counsel,\~I also was involved in the successful spin of the animal health business into Zoetis and helped in determining\plain\cf1\f51\fs20\ql whether to proceed with the spin, how to go through the transaction in a way that was tax efficient to shareholders, and how to\plain\cf1\f51\fs20\ql communicate those efforts in a compliant way. My work experience has spanned both large pharmaceutical companies as well as\plain\cf1\f51\fs20\ql small biotech companies, so I have a sense of what it takes to do a deal in a very hands-on way. Concerning Ironwood\u8217?s\plain\cf1\f51\fs20\ql planned separation, my transaction experience at Pfizer has certainly informed my thinking in terms of how to effectively\plain\cf1\f51\fs20\ql separate out pieces of a business that are part of a larger entity and how to capture the value that results from such a transaction.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\ql As a member of the compensation and HR committee, how does Ironwood use compensation to get the best out of all of\plain\cf1\f51\fs20\b\ql its people?\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\ql Ironwood has a thoughtful and engaged Board, and that\u8217?s part of what attracted me to joining the Board. I think the\plain\cf1\f51\fs20\ql Compensation and HR Committee is in sync with a thoughtfully run company that is determined to align management\u8217?s\plain\cf1\f51\fs20\ql incentives with delivering value. At Ironwood, the compensation committee is highly independent and makes its own judgments\plain\cf1\f51\fs20\ql and spends a lot of time looking at how management assesses itself and sets targets.\~ We take a very active view of\plain\cf1\f51\fs20\ql understanding how we want to fund the bonus pool. And from a Board standpoint, the vast majority of Ironwood\plain\cf1\f51\fs20\ql directors\u8217? compensation is not paid in cash. I think that reflects the company\u8217?s strong view of having\plain\cf1\f51\fs20\ql owner-oriented directors whose interests are directly aligned with shareholders.\par\pard\plain\cf1\f51\fs20\qc 5{\*\bkmkstart pb_5_071823_7056_12252269}{\*\bkmkend pb_5_071823_7056_12252269}\par\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par
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\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\ql Douglas Williams, PH.D.
\par\pard\plain\fs16\pard\plain\cf1\f51\fs20\b\ql Independent, Director since 2014\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\ql Codiak
\par\pard\plain\fs16\pard\plain\cf1\f51\fs20\ql President & CEO (2015 \u8211? Present)\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\ql Biogen
\par\pard\plain\fs16\pard\plain\cf1\f51\fs20\ql EVP, R&D (2011 \u8211? 2015)\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\ql ZymoGenetics
\par\pard\plain\fs16\pard\plain\cf1\f51\fs20\ql CEO (2009 \u8211? 2010)
\par\pard\plain\fs16\pard\plain\cf1\f51\fs20\ql President & Chief Scientific Officer (2007 \u8211? 2009)
\par\pard\plain\fs16\pard\plain\cf1\f51\fs20\ql EVP, R&D & Chief Scientific Officer (2004 \u8211? 2007)\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\ql Immunex
\par\pard\plain\fs16\pard\plain\cf1\f51\fs20\ql EVP & Chief Technology Officer, VP R&D & SVP Discovery Research (1988 \u8211? 2002)\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\ql Professional Highlights\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\li264\cf1\f51\fs20\ql Led ZymoGenetics\u8217? sale to Bristol-Myers Squibb\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\li264\cf1\f51\fs20\ql Member of Immunex Board when acquired by Amgen and part of integration team\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\li264\cf1\f51\fs20\ql Played a role in development of novel drugs including Enbrel, Tecfidera, and Spinraza\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\li264\cf1\f51\fs20\ql CEO and Board member of Codiak BioSciences, and Board member of Ovid Therapeutics and AC Immune\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\li264\cf1\f51\fs20\ql Former Board member of Immunex, ZymoGenetics, Regulus Therapeutics, and Oncothyreon\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\ql You have M&A experience as both an executive and a Board member. How did those experiences help you in the\plain\cf1\f51\fs20\b\ql Board\u8217?s review of the range of strategic options?\par\pard\plain\cf1\f51\fs20\b\ql \~\par\pard\plain\cf1\f51\fs20\ql Immunex and ZymoGenetics were publicly traded companies before being acquired by Amgen and Bristol-Myers Squibb. Each\plain\cf1\f51\fs20\ql Board had to make a decision as to what the proper course of action was given the fact that we had been approached in these\plain\cf1\f51\fs20\ql transactions, and whether the right decision was to sell or to follow another path. I have a lot of experience working with outside\plain\cf1\f51\fs20\ql financial advisors and going through the analytical process of determining the appropriate strategy. And then, ultimately, defining\plain\cf1\f51\fs20\ql what the appropriate price would be in a transaction of that sort. I also have experience in the capacity as a buyer, having been at\plain\cf1\f51\fs20\ql Biogen for a number of years. We acquired at least two companies in the time that I was there, both of which were acquired for\plain\cf1\f51\fs20\ql the purpose of adding to the existing Biogen pipeline.\par\pard\plain\cf1\f51\fs20\b\ql \~\par\pard\plain\cf1\f51\fs20\b\ql In your comprehensive review, how did the Board determine that the separation of the two businesses was the right path\plain\cf1\f51\fs20\b\ql forward for Ironwood?\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\ql As a Board, we periodically evaluate a variety of alternatives. We have been analyzing the performance of the business, progress\plain\cf1\f51\fs20\ql of the business, and debating a number of different options. Several of us had heard from investors the suggestion to split the\plain\cf1\f51\fs20\ql company. After a thorough review of the full range of strategic options, we unanimously came to the conclusion that a separation\plain\cf1\f51\fs20\ql was the right course of action designed to unlock value\u8212?and that this is the right time to do it\u8212?given the maturity of\plain\cf1\f51\fs20\ql the commercial business and the maturity of the sGC business. The breadth of opportunities that we\u8217?re seeing with the\plain\cf1\f51\fs20\ql sGC stimulators reminds me of what we saw in the early days with the TNF inhibitor class, which was a common mechanism\plain\cf1\f51\fs20\ql driving diseases in distinct tissues. That realization led to multiple, innovative and life-changing therapies. We are creating two\plain\cf1\f51\fs20\ql very distinct operating units that are both at a stage where they have the opportunity to create more value independently.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\qc 6{\*\bkmkstart pb_6_073626_9550_12252269}{\*\bkmkend pb_6_073626_9550_12252269}\par\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par
\page
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\ql How would you describe the dynamic of the Ironwood Board?\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\ql I have been on several Boards over the years and I find this one to be populated by particularly accomplished individuals in the\plain\cf1\f51\fs20\ql biotech and pharma industry. There is a great mix of skills and backgrounds among the directors. You don\u8217?t have too\plain\cf1\f51\fs20\ql many finance people or too many R&D people \u8212? just enough of each. It\u8217?s a really well-balanced mix of skillsets\plain\cf1\f51\fs20\ql that, from my perspective, cover the entirety of the kinds of issues that you are likely to face as a Board in this industry. It is a\plain\cf1\f51\fs20\ql group that is not afraid to speak up, is very engaged in Board meetings and continuously challenges management. It is also a\plain\cf1\f51\fs20\ql group that respects each other and functions at a high level. It is one of the strongest Boards that I have ever been associated\plain\cf1\f51\fs20\ql with.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\ql How did the Board evaluate Alex Denner\u8217?s candidacy?\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\ql It was a process to evaluate the existing Board\u8217?s composition and expertise in an effort to identify any gaps that could be\plain\cf1\f51\fs20\ql filled. Ultimately, we concluded that the requisite skills and experience needed to make the best decisions as we move forward\plain\cf1\f51\fs20\ql with the separation\u8212?decisions that are focused on advancing shareholder interests\u8212?were already around the table.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\qc IRONWOOD\u8217?S BOARD HAS THE RIGHT MIX OF SKILLS AND EXPERTISE\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\ql Amy, Larry and Doug \u8212? along with the entire Ironwood Board, bring together the right mix of skills and expertise to\plain\cf1\f51\fs20\ql oversee Ironwood at this important time in our transformation.\par\pard\plain\cf1\f51\fs20\ql \~
\par\pard\plain
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\pard\plain\intbl\cf1\f51\fs2\b\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs16\b\qc Broader\~Business\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs16\b\qc Healthcare\~Industry\cell{
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\pard\plain\intbl\cf1\f51\fs16\b\ql Ironwood\~Board\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs16\b\qc Capital
\par\pard\plain\intbl\fs16\pard\plain\intbl\cf1\f51\fs16\b\qc Allocation\~/
\par\pard\plain\intbl\fs16\pard\plain\intbl\cf1\f51\fs16\b\qc Finance\~/
\par\pard\plain\intbl\fs16\pard\plain\intbl\cf1\f51\fs16\b\qc Accounting\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs16\b\qc Strategic
\par\pard\plain\intbl\fs16\pard\plain\intbl\cf1\f51\fs16\b\qc Transactions\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs16\b\qc Risk
\par\pard\plain\intbl\fs16\pard\plain\intbl\cf1\f51\fs16\b\qc Management\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs16\b\qc Human
\par\pard\plain\intbl\fs16\pard\plain\intbl\cf1\f51\fs16\b\qc Capital\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs16\b\qc Public
\par\pard\plain\intbl\fs16\pard\plain\intbl\cf1\f51\fs16\b\qc Company
\par\pard\plain\intbl\fs16\pard\plain\intbl\cf1\f51\fs16\b\qc Board\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs16\b\qc Senior
\par\pard\plain\intbl\fs16\pard\plain\intbl\cf1\f51\fs16\b\qc Leadership
\par\pard\plain\intbl\fs16\pard\plain\intbl\cf1\f51\fs16\b\qc (small
\par\pard\plain\intbl\fs16\pard\plain\intbl\cf1\f51\fs16\b\qc biotech)\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs16\b\qc Senior
\par\pard\plain\intbl\fs16\pard\plain\intbl\cf1\f51\fs16\b\qc Leadership
\par\pard\plain\intbl\fs16\pard\plain\intbl\cf1\f51\fs16\b\qc (large
\par\pard\plain\intbl\fs16\pard\plain\intbl\cf1\f51\fs16\b\qc pharma)\cell\pard\plain\intbl\cf1\f51\fs2\b\qc \~\cell\pard\plain\intbl\cf1\f51\fs16\b\qc Customer\~/
\par\pard\plain\intbl\fs16\pard\plain\intbl\cf1\f51\fs16\b\qc Market\~Insights
\par\pard\plain\intbl\fs16\pard\plain\intbl\cf1\f51\fs16\b\qc (patient,\~payer,
\par\pard\plain\intbl\fs16\pard\plain\intbl\cf1\f51\fs16\b\qc physician)\cell{
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\pard\plain\intbl\cf1\f51\fs20\b\ql Terrance McGuire\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f54\fs20\b\qc ü\cell\pard\plain\intbl\cf1\f51\fs2\qc \~\cell\pard\plain\intbl\cf1\f54\fs20\b\qc ü\cell\pard\plain\intbl\cf1\f51\fs2\qc \~\cell\pard\plain\intbl\cf1\f54\fs20\b\qc ü\cell\pard\plain\intbl\cf1\f51\fs2\qc \~\cell\pard\plain\intbl\cf1\f51\fs2\qc \~\cell\pard\plain\intbl\cf1\f51\fs2\qc \~\cell\pard\plain\intbl\cf1\f54\fs20\b\qc ü\cell\pard\plain\intbl\cf1\f51\fs2\qc \~\cell\pard\plain\intbl\cf1\f51\fs2\qc \~\cell\pard\plain\intbl\cf1\f51\fs2\qc \~\cell\pard\plain\intbl\cf1\f51\fs2\qc \~\cell\pard\plain\intbl\cf1\f51\fs2\qc \~\cell\pard\plain\intbl\cf1\f51\fs2\qc \~\cell{
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\pard\plain\intbl\cf1\f51\fs20\b\ql Andrew Dreyfus\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f54\fs20\b\qc ü\cell\pard\plain\intbl\cf1\f51\fs2\qc \~\cell\pard\plain\intbl\cf1\f54\fs20\b\qc ü\cell\pard\plain\intbl\cf1\f51\fs2\qc \~\cell\pard\plain\intbl\cf1\f54\fs20\b\qc ü\cell\pard\plain\intbl\cf1\f51\fs2\qc \~\cell\pard\plain\intbl\cf1\f54\fs20\b\qc ü\cell\pard\plain\intbl\cf1\f51\fs2\qc \~\cell\pard\plain\intbl\cf1\f51\fs2\qc \~\cell\pard\plain\intbl\cf1\f51\fs2\qc \~\cell\pard\plain\intbl\cf1\f51\fs2\qc \~\cell\pard\plain\intbl\cf1\f51\fs2\qc \~\cell\pard\plain\intbl\cf1\f51\fs2\qc \~\cell\pard\plain\intbl\cf1\f51\fs2\qc \~\cell\pard\plain\intbl\cf1\f54\fs20\b\qc ü\cell{
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\pard\plain\intbl\cf1\f51\fs20\b\ql Marsha Fanucci\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f54\fs20\b\qc ü\cell\pard\plain\intbl\cf1\f51\fs2\qc \~\cell\pard\plain\intbl\cf1\f54\fs20\b\qc ü\cell\pard\plain\intbl\cf1\f51\fs2\qc \~\cell\pard\plain\intbl\cf1\f54\fs20\b\qc ü\cell\pard\plain\intbl\cf1\f51\fs2\qc \~\cell\pard\plain\intbl\cf1\f54\fs20\b\qc ü\cell\pard\plain\intbl\cf1\f51\fs2\qc \~\cell\pard\plain\intbl\cf1\f54\fs20\b\qc ü\cell\pard\plain\intbl\cf1\f51\fs2\qc \~\cell\pard\plain\intbl\cf1\f51\fs2\qc \~\cell\pard\plain\intbl\cf1\f51\fs2\qc \~\cell\pard\plain\intbl\cf1\f54\fs20\b\qc ü\cell\pard\plain\intbl\cf1\f51\fs2\qc \~\cell\pard\plain\intbl\cf1\f51\fs2\qc \~\cell{
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx1678\clshdng100\clcfpat11\clcbpat11\cellx1877\clshdng100\clcfpat11\clcbpat11\cellx2839\clshdng100\clcfpat11\clcbpat11\cellx3048\clshdng100\clcfpat11\clcbpat11\cellx4019\clshdng100\clcfpat11\clcbpat11\cellx4228\clshdng100\clcfpat11\clcbpat11\cellx5205\clshdng100\clcfpat11\clcbpat11\cellx5414\clshdng100\clcfpat11\clcbpat11\cellx6056\clshdng100\clcfpat11\clcbpat11\cellx6265\clshdng100\clcfpat11\clcbpat11\cellx7118\clshdng100\clcfpat11\clcbpat11\cellx7317\clshdng100\clcfpat11\clcbpat11\cellx8180\clshdng100\clcfpat11\clcbpat11\cellx8462\clshdng100\clcfpat11\clcbpat11\cellx9325\clshdng100\clcfpat11\clcbpat11\cellx9607\clshdng100\clcfpat11\clcbpat11\cellx10800\trrh248\row}}}
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\pard\plain\intbl\cf1\f51\fs20\b\ql Peter Hecht, Ph.D.\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f54\fs20\b\qc ü\cell\pard\plain\intbl\cf1\f51\fs2\qc \~\cell\pard\plain\intbl\cf1\f54\fs20\b\qc ü\cell\pard\plain\intbl\cf1\f51\fs2\qc \~\cell\pard\plain\intbl\cf1\f54\fs20\b\qc ü\cell\pard\plain\intbl\cf1\f51\fs2\qc \~\cell\pard\plain\intbl\cf1\f54\fs20\b\qc ü\cell\pard\plain\intbl\cf1\f51\fs2\qc \~\cell\pard\plain\intbl\cf1\f51\fs2\qc \~\cell\pard\plain\intbl\cf1\f51\fs2\qc \~\cell\pard\plain\intbl\cf1\f54\fs20\b\qc ü\cell\pard\plain\intbl\cf1\f51\fs2\qc \~\cell\pard\plain\intbl\cf1\f51\fs2\qc \~\cell\pard\plain\intbl\cf1\f51\fs2\qc \~\cell\pard\plain\intbl\cf1\f51\fs2\qc \~\cell{
{\trowd\cellx1678\cellx1877\cellx2839\cellx3048\cellx4019\cellx4228\cellx5205\cellx5414\cellx6056\cellx6265\cellx7118\cellx7317\cellx8180\cellx8462\cellx9325\cellx9607\cellx10800\trrh248\row}}}\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\qc 7{\*\bkmkstart pb_7_074410_5335_12252269}{\*\bkmkend pb_7_074410_5335_12252269}\par\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par
\page
\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\ql \~
\par\pard\plain
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\pard\plain\intbl\cf1\f51\fs20\b\ql Julie McHugh\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f54\fs20\b\qc ü\cell\pard\plain\intbl\cf1\f51\fs2\qc \~\cell\pard\plain\intbl\cf1\f54\fs20\b\qc ü\cell\pard\plain\intbl\cf1\f51\fs2\qc \~\cell\pard\plain\intbl\cf1\f51\fs2\qc \~\cell\pard\plain\intbl\cf1\f51\fs2\qc \~\cell\pard\plain\intbl\cf1\f54\fs20\b\qc ü\cell\pard\plain\intbl\cf1\f51\fs2\qc \~\cell\pard\plain\intbl\cf1\f54\fs20\b\qc ü\cell\pard\plain\intbl\cf1\f51\fs2\qc \~\cell\pard\plain\intbl\cf1\f54\fs20\b\qc ü\cell\pard\plain\intbl\cf1\f51\fs2\qc \~\cell\pard\plain\intbl\cf1\f54\fs20\b\qc ü\cell\pard\plain\intbl\cf1\f51\fs2\qc \~\cell\pard\plain\intbl\cf1\f54\fs20\b\qc ü\cell{
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\pard\plain\intbl\cf1\f51\fs20\b\ql Lawrence Olanoff,\plain\intbl\cf1\f51\fs20\b\ql M.D., Ph.D.\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\qc \~\cell\pard\plain\intbl\cf1\f51\fs2\qc \~\cell\pard\plain\intbl\cf1\f54\fs20\b\qc ü\cell\pard\plain\intbl\cf1\f51\fs2\qc \~\cell\pard\plain\intbl\cf1\f54\fs20\b\qc ü\cell\pard\plain\intbl\cf1\f51\fs2\qc \~\cell\pard\plain\intbl\cf1\f54\fs20\b\qc ü\cell\pard\plain\intbl\cf1\f51\fs2\qc \~\cell\pard\plain\intbl\cf1\f54\fs20\b\qc ü\cell\pard\plain\intbl\cf1\f51\fs2\qc \~\cell\pard\plain\intbl\cf1\f54\fs20\b\qc ü\cell\pard\plain\intbl\cf1\f51\fs2\qc \~\cell\pard\plain\intbl\cf1\f54\fs20\b\qc ü\cell\pard\plain\intbl\cf1\f51\fs2\qc \~\cell\pard\plain\intbl\cf1\f54\fs20\b\qc ü\cell{
{\trowd\cellx1728\cellx1944\cellx2916\cellx3132\cellx4104\cellx4320\cellx5291\cellx5506\cellx6153\cellx6368\cellx7232\cellx7447\cellx8311\cellx8526\cellx9390\cellx9605\cellx10800\trrh495\row}}}
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx1728\clshdng100\clcfpat11\clcbpat11\cellx1944\clshdng100\clcfpat11\clcbpat11\cellx2916\clshdng100\clcfpat11\clcbpat11\cellx3132\clshdng100\clcfpat11\clcbpat11\cellx4104\clshdng100\clcfpat11\clcbpat11\cellx4320\clshdng100\clcfpat11\clcbpat11\cellx5291\clshdng100\clcfpat11\clcbpat11\cellx5506\clshdng100\clcfpat11\clcbpat11\cellx6153\clshdng100\clcfpat11\clcbpat11\cellx6368\clshdng100\clcfpat11\clcbpat11\cellx7232\clshdng100\clcfpat11\clcbpat11\cellx7447\clshdng100\clcfpat11\clcbpat11\cellx8311\clshdng100\clcfpat11\clcbpat11\cellx8526\clshdng100\clcfpat11\clcbpat11\cellx9390\clshdng100\clcfpat11\clcbpat11\cellx9605\clshdng100\clcfpat11\clcbpat11\cellx10800\trrh248
\pard\plain\intbl\cf1\f51\fs20\b\ql Edward Owens\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f54\fs20\b\qc ü\cell\pard\plain\intbl\cf1\f51\fs2\qc \~\cell\pard\plain\intbl\cf1\f54\fs20\b\qc ü\cell\pard\plain\intbl\cf1\f51\fs2\qc \~\cell\pard\plain\intbl\cf1\f54\fs20\b\qc ü\cell\pard\plain\intbl\cf1\f51\fs2\qc \~\cell\pard\plain\intbl\cf1\f51\fs2\qc \~\cell\pard\plain\intbl\cf1\f51\fs2\qc \~\cell\pard\plain\intbl\cf1\f51\fs2\qc \~\cell\pard\plain\intbl\cf1\f51\fs2\qc \~\cell\pard\plain\intbl\cf1\f51\fs2\qc \~\cell\pard\plain\intbl\cf1\f51\fs2\qc \~\cell\pard\plain\intbl\cf1\f51\fs2\qc \~\cell\pard\plain\intbl\cf1\f51\fs2\qc \~\cell\pard\plain\intbl\cf1\f51\fs2\qc \~\cell{
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\pard\plain\intbl\cf1\f51\fs20\b\ql Amy W. Schulman\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f54\fs20\b\qc ü\cell\pard\plain\intbl\cf1\f51\fs2\qc \~\cell\pard\plain\intbl\cf1\f54\fs20\b\qc ü\cell\pard\plain\intbl\cf1\f51\fs2\qc \~\cell\pard\plain\intbl\cf1\f54\fs20\b\qc ü\cell\pard\plain\intbl\cf1\f51\fs2\qc \~\cell\pard\plain\intbl\cf1\f54\fs20\b\qc ü\cell\pard\plain\intbl\cf1\f51\fs2\qc \~\cell\pard\plain\intbl\cf1\f54\fs20\b\qc ü\cell\pard\plain\intbl\cf1\f51\fs2\qc \~\cell\pard\plain\intbl\cf1\f54\fs20\b\qc ü\cell\pard\plain\intbl\cf1\f51\fs2\qc \~\cell\pard\plain\intbl\cf1\f54\fs20\b\qc ü\cell\pard\plain\intbl\cf1\f51\fs2\qc \~\cell\pard\plain\intbl\cf1\f54\fs20\b\qc ü\cell{
{\trowd\cellx1728\cellx1944\cellx2916\cellx3132\cellx4104\cellx4320\cellx5291\cellx5506\cellx6153\cellx6368\cellx7232\cellx7447\cellx8311\cellx8526\cellx9390\cellx9605\cellx10800\trrh248\row}}}
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx1728\clshdng100\clcfpat11\clcbpat11\cellx1944\clshdng100\clcfpat11\clcbpat11\cellx2916\clshdng100\clcfpat11\clcbpat11\cellx3132\clshdng100\clcfpat11\clcbpat11\cellx4104\clshdng100\clcfpat11\clcbpat11\cellx4320\clshdng100\clcfpat11\clcbpat11\cellx5291\clshdng100\clcfpat11\clcbpat11\cellx5506\clshdng100\clcfpat11\clcbpat11\cellx6153\clshdng100\clcfpat11\clcbpat11\cellx6368\clshdng100\clcfpat11\clcbpat11\cellx7232\clshdng100\clcfpat11\clcbpat11\cellx7447\clshdng100\clcfpat11\clcbpat11\cellx8311\clshdng100\clcfpat11\clcbpat11\cellx8526\clshdng100\clcfpat11\clcbpat11\cellx9390\clshdng100\clcfpat11\clcbpat11\cellx9605\clshdng100\clcfpat11\clcbpat11\cellx10800\trrh495
\pard\plain\intbl\cf1\f51\fs20\b\ql Douglas Williams,\plain\intbl\cf1\f51\fs20\b\ql Ph.D.\cell\pard\plain\intbl\cf1\f51\fs2\ql \~\cell\pard\plain\intbl\cf1\f51\fs2\qc \~\cell\pard\plain\intbl\cf1\f51\fs2\qc \~\cell\pard\plain\intbl\cf1\f54\fs20\b\qc ü\cell\pard\plain\intbl\cf1\f51\fs2\qc \~\cell\pard\plain\intbl\cf1\f51\fs2\qc \~\cell\pard\plain\intbl\cf1\f51\fs2\qc \~\cell\pard\plain\intbl\cf1\f54\fs20\b\qc ü\cell\pard\plain\intbl\cf1\f51\fs2\qc \~\cell\pard\plain\intbl\cf1\f54\fs20\b\qc ü\cell\pard\plain\intbl\cf1\f51\fs2\qc \~\cell\pard\plain\intbl\cf1\f54\fs20\b\qc ü\cell\pard\plain\intbl\cf1\f51\fs2\qc \~\cell\pard\plain\intbl\cf1\f54\fs20\b\qc ü\cell\pard\plain\intbl\cf1\f51\fs2\qc \~\cell\pard\plain\intbl\cf1\f51\fs2\qc \~\cell{
{\trowd\clshdng100\clcfpat11\clcbpat11\cellx1728\clshdng100\clcfpat11\clcbpat11\cellx1944\clshdng100\clcfpat11\clcbpat11\cellx2916\clshdng100\clcfpat11\clcbpat11\cellx3132\clshdng100\clcfpat11\clcbpat11\cellx4104\clshdng100\clcfpat11\clcbpat11\cellx4320\clshdng100\clcfpat11\clcbpat11\cellx5291\clshdng100\clcfpat11\clcbpat11\cellx5506\clshdng100\clcfpat11\clcbpat11\cellx6153\clshdng100\clcfpat11\clcbpat11\cellx6368\clshdng100\clcfpat11\clcbpat11\cellx7232\clshdng100\clcfpat11\clcbpat11\cellx7447\clshdng100\clcfpat11\clcbpat11\cellx8311\clshdng100\clcfpat11\clcbpat11\cellx8526\clshdng100\clcfpat11\clcbpat11\cellx9390\clshdng100\clcfpat11\clcbpat11\cellx9605\clshdng100\clcfpat11\clcbpat11\cellx10800\trrh495\row}}}\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\ql Your Board uses a rigorous process to determine the appropriate Board make-up, and as a result has an excellent group of\plain\cf1\f51\fs20\ql individuals with the appropriate skills. Moreover, the Board\u8217?s annual evaluation process serves to improve the\plain\cf1\f51\fs20\ql effectiveness of all members and the Board as a whole. Ironwood strongly believes that Sarissa has not made a compelling case\plain\cf1\f51\fs20\ql for Ironwood to add Alex Denner to the Board, given the skills, experience and diversity of the existing directors who have acted\plain\cf1\f51\fs20\ql to unlock value for Ironwood shareholders.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\qc PROTECT THE VALUE OF YOUR INVESTMENT IN IRONWOOD:
\par\pard\plain\fs16\pard\plain\cf1\f51\fs20\b\qc VOTE THE WHITE PROXY CARD TODAY\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\ql Whether or not you plan to attend the Annual Meeting, you have an opportunity to protect your investment in Ironwood by\plain\cf1\f51\fs20\ql voting the\plain\cf1\f51\fs20\b\ul\ql WHITE\plain\cf1\f51\fs20\ql proxy card\plain\cf1\f51\fs20\b\ql \u8220?FOR ALL\u8221?\plain\cf1\f51\fs20\ql of our nominees.\plain\cf1\f51\fs20\b\ql YOUR VOTE IS EXTREMELY IMPORTANT!\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\ql We urge you to vote today by telephone,\~Internet, or by signing and dating the enclosed\plain\cf1\f51\fs20\b\ul\ql WHITE\plain\cf1\f51\fs20\ql proxy card and returning it in\plain\cf1\f51\fs20\ql the postage-paid envelope provided.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\ql Please disregard any gold proxy card you get from Sarissa.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\ql If you have any questions about how to vote your shares, or need additional assistance, please contact our proxy solicitor,\plain\cf1\f51\fs20\ql MacKenzie Partners,\~Inc. toll-free at (800)\~322-2885 or at (212)\~929-5500 or via email to proxy@mackenziepartners.com.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\ql About Ironwood Pharmaceuticals\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\ql Ironwood Pharmaceuticals\~(NASDAQ: IRWD) is a commercial biotechnology company focused on creating medicines that make\plain\cf1\f51\fs20\ql a difference for patients, building value for our fellow shareholders, and empowering our passionate team. We are\plain\cf1\f51\fs20\ql commercializing two innovative primary care products: linaclotide, the U.S. branded prescription market leader for adults with\plain\cf1\f51\fs20\ql irritable bowel syndrome with constipation (IBS-C) or chronic idiopathic constipation (CIC), and lesinurad, which is approved to\plain\cf1\f51\fs20\ql be taken with a xanthine oxidase inhibitor (XOI), or as a fixed-dose combination with allopurinol, for the treatment of\plain\cf1\f51\fs20\ql hyperuricemia associated with gout. We are also advancing a pipeline of innovative product candidates in areas of significant\plain\cf1\f51\fs20\ql unmet need, including uncontrolled gastroesophageal reflux disease, diabetic nephropathy, heart failure with preserved ejection\plain\cf1\f51\fs20\ql fraction, achalasia and\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\qc 8{\*\bkmkstart pb_8_075230_5796_12252269}{\*\bkmkend pb_8_075230_5796_12252269}\par\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par
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\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\ql sickle cell disease. Ironwood was founded in 1998 and is headquartered in\~Cambridge, Mass. For more information, please visit\plain\cf1\f51\fs20\ql www.ironwoodpharma.com or www.twitter.com/ironwoodpharma; information that may be important to investors will be\plain\cf1\f51\fs20\ql routinely posted in both these locations.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\ql Forward-Looking Statements\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\ql This press release contains forward-looking statements. Investors are cautioned not to place undue reliance on these\plain\cf1\f51\fs20\ql forward-looking statements, including statements about the benefits of a potential separation, including with respect to\plain\cf1\f51\fs20\ql Ironwood\u8217?s and R&D Co.\u8217?s competitive position and enhanced operational, commercial and scientific effectiveness;\plain\cf1\f51\fs20\ql the structure, including the division of assets among Ironwood and R&D Co., and impact of a separation;\~ the monetization of\plain\cf1\f51\fs20\ql drug candidates; the commercial potential, prevalence, and the growth in, and potential demand for, linaclotide, lesinurad and\plain\cf1\f51\fs20\ql other product candidates (and the drivers, timing and impact thereof), for each of Ironwood and R&D Co., as applicable;\~ and\plain\cf1\f51\fs20\ql Ironwood\u8217?s and R&D Co.\u8217?s financial performance and results and expectations related thereto (including the drivers\plain\cf1\f51\fs20\ql and timing thereof).\~ Each forward-looking statement is subject to risks and uncertainties that could cause actual results to differ\plain\cf1\f51\fs20\ql materially from those expressed or implied in such statement. Applicable risks and uncertainties include those related to the\plain\cf1\f51\fs20\ql possibility that we may not complete the separation on the terms or timeline currently contemplated if at all, achieve the expected\plain\cf1\f51\fs20\ql benefits of a separation, and that a separation could harm our business, results of operations and financial condition; the risk that\plain\cf1\f51\fs20\ql the transaction might not be tax-free; the risk that we may be unable to make, on a timely or cost-effective basis, the changes\plain\cf1\f51\fs20\ql necessary to operate as independent companies; R&D Co.\u8217?s lack of independent operating history and the risk that its\plain\cf1\f51\fs20\ql accounting and other management systems may not be prepared to meet the financial reporting and other requirements of\plain\cf1\f51\fs20\ql operating as an independent public company; the risk that a separation may adversely impact our ability to attract or retain key\plain\cf1\f51\fs20\ql personnel; the effectiveness of development and commercialization efforts by us and our partners; preclinical and clinical\plain\cf1\f51\fs20\ql development, manufacturing and formulation development; the risk that findings from our completed nonclinical and clinical\plain\cf1\f51\fs20\ql studies may not be replicated in later studies; efficacy, safety and tolerability of linaclotide, lesinurad and our product candidates;\plain\cf1\f51\fs20\ql decisions by regulatory and judicial authorities; the risk that we are unable to successfully commercialize lesinurad or realize the\plain\cf1\f51\fs20\ql anticipated benefits of the lesinurad transaction; the risk that we may never get sufficient patent protection for linaclotide,\plain\cf1\f51\fs20\ql lesinurad and our product candidates or that we are not able to successfully protect such patents; the outcomes in legal\plain\cf1\f51\fs20\ql proceedings to protect or enforce the patents relating to our products and product candidates, including ANDA litigation;\plain\cf1\f51\fs20\ql developments in the intellectual property landscape; challenges from and rights of competitors or potential competitors; the risk\plain\cf1\f51\fs20\ql that our planned investments do not have the anticipated effect on our company revenues, linaclotide, lesinurad or our product\plain\cf1\f51\fs20\ql candidates; the risk that we are unable to manage our operating expenses or cash use for operations, or are unable to\plain\cf1\f51\fs20\ql commercialize our products, within the guided ranges or otherwise as expected; and the risks listed under the heading\plain\cf1\f51\fs20\ql \u8220?Risk Factors\u8221? and elsewhere in Ironwood\u8217?s Quarterly Report on Form\~10-Q for the quarter ended March\~31,\plain\cf1\f51\fs20\ql 2018, and in our subsequent SEC filings. These forward-looking statements (except as otherwise noted) speak only as of the date\plain\cf1\f51\fs20\ql of this press release and Ironwood undertakes no obligation to update these forward-looking statements.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\qc 9{\*\bkmkstart pb_9_075244_2897_12252269}{\*\bkmkend pb_9_075244_2897_12252269}\par\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par
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\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\ql Additional Information\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\ql On May\~2, 2018,\~Ironwood filed a definitive proxy statement and WHITE proxy card with the U.S. Securities and Exchange\plain\cf1\f51\fs20\ql Commission (the \u8220?SEC\u8221?) in connection with the company\u8217?s 2018 Annual Meeting of Shareholders.\plain\cf1\f51\fs20\ql SHAREHOLDERS ARE STRONGLY ENCOURAGED TO READ SUCH DEFINITIVE PROXY STATEMENT AND\plain\cf1\f51\fs20\ql ACCOMPANYING WHITE PROXY CARD AS THEY CONTAIN IMPORTANT INFORMATION. Shareholders are able to\plain\cf1\f51\fs20\ql obtain the proxy statement, any amendments or supplements to the proxy statement and other documents filed by the company\plain\cf1\f51\fs20\ql with the SEC for no charge at the SEC\u8217?s website at www.sec.gov. Copies are also available at no charge at the\plain\cf1\f51\fs20\ql company\u8217?s website at\~\plain\cf1\f51\fs16\ql www.ironwoodpharma.com\plain\cf1\f51\fs20\ql . If you have any questions regarding this information or the proxy materials,\plain\cf1\f51\fs20\ql please contact MacKenzie Partners,\~Inc., our proxy solicitor assisting us in connection with the annual meeting, toll-free at\plain\cf1\f51\fs20\ql (800)\~322-2885 or at (212)\~929-5500 or via email to proxy@mackenziepartners.com.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\ql Any trademarks referred to in this press release are the property of their respective owners.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\ql Investors:\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\ql Meredith Kaya, 617-374-5082\par\pard\plain\cf1\f51\fs20\ql Vice President,\~Investor Relations and Corporate Communications
\par\pard\plain\fs16\pard\plain\cf1\f51\fs20\ql mkaya@ironwoodpharma.com\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\ql Media:\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\ql Andi Rose / Mahmoud Siddig\par\pard\plain\cf1\f51\fs20\ql Joele Frank, Wilkinson Brimmer Katcher\par\pard\plain\cf1\f51\fs20\ql 212-355-4449\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\qc 10{\*\bkmkstart pb_10_075305_3020_12252269}{\*\bkmkend pb_10_075305_3020_12252269}\par\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par}