School of Medicine

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Current Research and Scholarly Interests
My interest is in the care and evaluation of newborns. In particular, I have been focusing on improving the educational experience for our residents and students in the nursery regarding the examination and management of term or near-term infants.

Bio
Maya Adam MD has been teaching at Stanford University since 2009. She received her BA in Human Biology from Stanford before studying medicine at the University of British Columbia in Vancouver, Canada. Prior to her post-secondary studies, she spent 10 years as a professional ballet dancer with the State Theater of Saxony in Germany. At the Stanford School of Medicine, Adam creates online educational content for the Re-imagining Medical Education Project, led by Charles Prober MD, Senior Associate Dean for Medical Education. In the Program in Human Biology, Adam teaches courses on child health and nutrition. In 2013, Adam created the free, massive open online course Stanford Child Nutrition and Cooking, a public health education outreach effort that has reached more than 300,000 international students. She is also the founder of a non-profit organization called Just Cook for Kids. In 2014, Adam started applying the new teaching technologies being developed at Stanford to the creation of digital teaching tools designed to support the work of international community health workers. The resulting Stanford Health Outreach App is now being used by community health organizations in South Africa and Guatemala and the teaching videos associated with the app have been translated into Xhosa, Spanish and Hindi. In 2015 Adam created the online CME course Food and Medicine and the parallel open online course, Food and Health. She is the author of Food Love Family: A Practical Guide to Child Nutrition.

Current Research and Scholarly Interests
I am interested in the prevention and management of infectious complication in pediatric oncology patients. I am also interested in developing a protocol for the management of low risk patients with fever and neutropenia.

Current Research and Scholarly Interests
Hematopoietic Stem cell biology-created a SCID mouse model to study engraftment of cord blood derived hematopoietic cells and use of this model to develop gene transfer technology for Fanconi anemia.Clinical research interests are to develop new protocols to reduce toxicity from high doses of chemotherapy and radiation therapy and development of a comprehensive late effects clinic for the long term follow up of transplant patients.

Current Research and Scholarly Interests
The overall objective of the Alvira Laboratory is to elucidate the mechanisms that promote postnatal lung development and repair, by focusing on three main scientific goals: (i) identification of the signaling pathways that direct the transition between the saccular and alveolar stages of lung development; (ii) exploration of the interplay between postnatal vascular and alveolar development; and (iii) determination of developmentally regulated pathways that mediate lung repair after injury.

Current Research and Scholarly Interests
My laboratory studies the strategies pathogens utilize to colonize and subvert the epithelial barrier. We have focused on the epithelial junctions as a target for bacterial pathogens, since the cell-cell junctions serve as both a barrier to infection and also a major control site for epithelial function. In particular, we are interested in how the gastric pathogen Helicobater pylori may cause cancer by interfering with cell signaling at the epithelial junctions. We are also studying how various bacteria cross and invade the epithelium. For example, we recently found that Listeria monocytogenes targets a specialized subset of cell-cell junctions at the tip of the intestinal villi to find its receptor for invasion. We are interested in determining whether this mode of gastrointestinal invasion of the epithelium is also used by other gastrointestinal pathogens.

Current Research and Scholarly Interests
Bone marrow transplantation (BMT) is a treatment modality which is being broadly applied to a growing number of disorders. Increasing success with BMT is offering improved survival to pediatric and adult patients with acute leukemia, chronic leukemia, lymphomas, and a variety of solid tumors as well as severe aplastic anemia.

The first 28 years of my career were spent in clinical practice combining both DBP and primary care (the latter focused on serving CSHCN). During those years I was involved in numerous divide-bridging efforts - including programs to coordinate inpatient & outpatient medicine, connect tertiary & primary care, and promote teamwork between pediatricians, psychologists, nurse practitioners, and other community partners. I founded my own solo practice in 1989 and managed its growth to an 8-provider group over the next 25 years. Our practice was a founding member of the PPOC and I served on its board of directors for 6 years. The PPOC is one of the largest pediatric IPA’s in the country, with >200 member providers affiliated with Boston Children's Hospital. Over the years we've been involved in groundbreaking QI initiatives including those involving asthma, weight, and ADHD management; medical home; and behavioral health integration with primary care.

I’m pleased now to have an opportunity for a “second act” on the clinician-educator track here at Stanford. I hope to use my unique experience straddling primary care and sub-specialty worlds to develop programs supporting DB assessment and care inside the medical home generally, and across the Packard Children's Health Alliance primary care network in particular.

Current Research and Scholarly Interests
Developmental Physiology and Sudden Infant Death Syndrome Research Laboratory closed in 2008.

Current effort, as Chair of Task Force and neonatal consult at the FDA, is to establish through consensus a culture of investigation and collaboration for all clinical neonatology practices: academic, corporate and community based to maximize the opportunity to participate in research effort needed for the regulatory approval of neonatal therapeutics to improve the outcome of critically ill infants.

Current Research and Scholarly Interests
Our laboratory investigates the pathogenesis of varicella zoster virus (VZV) infection, focusing on the functional roles of particular viral gene products in pathogenesis and virus-cell interactions in differentiated human cells in humans and in Scid-hu mouse models of VZV cell tropisms in vivo, and the immunobiology of VZV infections.

Current Research and Scholarly Interests
Virtual Reality Congenital Heart Disease experience: The Stanford Virtual Heart. Diagnosis and treatment of acute kidney injury (AKI) in children with cardiac disease, especially after surgical repair with cardiopulmonary bypass. Published our findings on prophylactic aminophylline use in children who undergo surgery with bypass; the "KID PRO-AM" (KIDney PROtection with AMinophyllline) study.

Current Research and Scholarly Interests
In the coming years, I plan to further determine the genetic and immunological basis of diseases with autoimmunity or immune dysregulation in children. I believe that much can still be learned from the in depth mechanistic studies of pediatric autoimmune diseases. Genomic analysis of the patients' samples has become possible which may provide a rapid indication of altered target molecules. I plan to implement robust functional studies to define the consequences of these genetic abnormalities and bridge them to the patient's clinical phenotype.

Understanding functional consequences of gene mutations in single case/family first and then validating the molecular and cellular defects in other patients with similar phenotypes, will anticipate and complement cellular and gene therapy strategies.

Current Research and Scholarly Interests
Prevention of osteoporosis begins in childhood and adolescence by measures that maximize acquistion of bone mineral during the critical adolescent years. Body mass, calcium nutriture, physical activity, growth and sex steroid hormones, and genetic factors are all thought to be important determinants of bone mass although the relative contribution of each remains controversial.

Current Research and Scholarly Interests
Dr. Banda’s research aims to design, test, and disseminate creative solutions to prevent and treat childhood obesity. His research focuses on two areas: 1) developing, evaluating, and disseminating community-based interventions to decrease sedentary behavior, increase physical activity, and prevent and treat obesity in children and 2) using accelerometers and innovative data analysis strategies to improve measures of sleep, sedentary behavior, and physical activity.

Current Research and Scholarly Interests
My goal during my postdoc training is to develop a state-of-the-art CRISPR-Cas9-based genetic approach to explore the host’s contribution to the intra-erythrocytic cell cycle of P. falciparum malaria parasites. I hypothesize that there are multiple host genes that influence the ability of parasites to grow and develop within RBCs, the discovery of which could lead to the development of host-directed therapeutics for malaria.

Current Research and Scholarly Interests
Dr. Bejerano, co-discoverer of ultraconserved elements, studies the Human Genome. His research focuses on genome sequence and function in both humans and related primate, mammalian and vertebrate species. He is deeply interested in mapping both coding and non-coding genome sequence variation to phenotype differences, and in extracting specific genetic insights from high throughput sequencing measurements, in the contexts of development and developmental abnormalities.

Current Research and Scholarly Interests
My research focuses on improving health care delivery systems for children, adolescents and young adults with chronic illness. I have a particular interest on the transition from pediatric to adult-oriented health care, development of chronic disease self-management skills, and assessment of patient reported outcomes.

Current Research and Scholarly Interests
My research has involved the use of new technologies to create different types of patient-doctor transactions. I am also interested in how these new transactions impact clinical care processes. Current work includes the evaluation of a patient portal for children with cystic fibrosis, the use of telemedicine to bring asthma experts into the schools and the attitudes of teens and parents about the use of a secure patient portal for teens.

Current Research and Scholarly Interests
1. Role of the G protein coupled receptors in regulating mitochondrial structure and function.2. Differences between R and L ventricular responses to stress, including gene expression and miR regulation.3. Using iPSC-derived myocytes to understand heart failure and congenital heart disease.4. Tools for evaluation of cardiac physiology in transgenic mice and isolated cardiomyocytes.5. Anti-body mediated rejection.6. Biomarkers for post-transplant lymphoproliferative disorder.

Current Research and Scholarly Interests
My interests include the genetics of autism and other developmental disorders. In collaboration with colleagues at Stanford, I am working to develop induced pluripotent stem cell (iPSC) models of genetic disorders associated with developmental disability. I am also engaged in the application of new technologies (Whole genome sequencing, Multi-omics profiling) for the diagnosis of developmental disorders.

Current Research and Scholarly Interests
Our research focuses on the pathogenesis and treatment of acute and chronic neonatal lung injury and the mechanisms that regulate lung fluid balance and alveolar & pulmonary vascular development after premature birth.

Current Research and Scholarly Interests
I am interested in graduate medical education -- particularly in understanding how learners learn best and how to optimize graduate medical education given recent work hours changes, increasing patient safety standards which have led to increased supervision, and limited longitudinal exposure with faculty. My current studies include: (1) Coaching Initiative; (2) Improving Family-Centered Rounds to Improve Safety and Communication, (3) Shared Decision-Making, and (4) Scholarly Concentrations.

Current Role at Stanford
Program Director, Pediatric Advocacy Program, Stanford School of MedicineCo-Director for the Scholarly Concentration in Community Engagement and Advocacy, Stanford Pediatric Residency ProgramInstructor for graduate level qualitative methods and community engagement courses, Stanford University

Current Research and Scholarly Interests
My major interest is in type 1 diabetes mellitus, continuous glucose sensor, and the development of an artificial pancreas. Other research interests include using continuous glucose monitoring and algorithms to control blood glucose levels in intensive care units.

Current Research and Scholarly Interests
Our laboratory's goal is to address fundamental and therapeutic questions in immunology using innovative nanotechnological and biophysical approaches to visualize and manipulate cells. Our primary focus is on understanding the molecular controls that balance T cell activation versus tolerance. The ultimate aim of our work is to manipulate T cell signaling pathways to control immunologically-mediated diseases.

Current Research and Scholarly Interests
I am studying health inequalities and disparities experienced by children with special health care needs. My past work was focused on pediatric health needs in a Vietnamese-American community. My current research investigates the determinants of differential health outcomes of in patients with cystic fibrosis, specifically looking at ethnicity/race, health care utilization, and genetics.

Current Research and Scholarly Interests
Our research focuses on epidemiologic studies related to maternal and child health. Current projects address congenital anomalies of craniofacial, urogenital, musculoskeletal and central nervous system structures and how they relate to genetics, nutrition, stress, and environmental contaminants. Physiologic pathways encompassed by these studies include one-carbon metabolism, oxidative stress, HPA axis activation, and sex steroid metabolism. In particular, we are interested in discovering how environmental factors and genetic susceptibility may interact to affect these pathways and impact risks of these outcomes. Other active projects include investigations into the etiology of preterm delivery and stillbirth, and factors affecting the care and outcomes of infants with birth defects.

Bio
Christina Chan was an undergraduate of Stanford University ('01). Her research focus and publications have focused on neonatal immune biomarker investigation and human nutrition, and she has also been involved in point-of-care ultrasound use in the NICU, neonatal resuscitation quality improvement, and PICC line management as part of a multidisciplinary team. In addition to her academic interests, she has spent time working in resource limited settings providing critical care for newborns in Kampala, Uganda and providing mobile health clinics in Cuc Phuong, Vietnam. She is particularly interested in continuing to investigate the use of human milk and its role in neonatal immune protection as well as continuing to promote the education of our NICU families and all the staff participating in neonatal care.

Current Research and Scholarly Interests
My research interest is in viral infections commonly affecting immunocompromised patients, investigating viral pathogenesis and anti-viral immunity. As Co-director of the Pediatric Infectious Diseases Program in Immunocompromised Hosts, I develop and conduct clinical studies to establish best practices. I am also the Co-Chair for a multi-institution microbiology and immunology curriculum development project (with the Robert Wood Johnson Foundation) that aims to re-imagine how medical students.

Current Research and Scholarly Interests
Active Wnt signaling maintains somatic stem cells in many organ systems. Using Wnt target genes as markers, we have characterized distinct cell populations with stem cell behavior in the inner ear, an organ thought to be terminally differentiated. Ongoing work focuses on delineating the developing significance of these putative stem/progenitor cells and their behavior after damage.