Six athletes (one female, five male) represented the United States in wheelchair fencing at the London 2012 Paralympic Games. Of the U.S. athletes who competed in the sport, only one had a military background: Mario Rodriguez, who is retired U.S. Air Force.

The 2016 U.S. Paralympic Wheelchair Fencing Team will be announced in 2016. The team will be determined based on selection procedures developed by U.S. Fencing, the National Governing Body for the sport of wheelchair fencing in the United States, and approved by the United States Olympic Committee.