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Abstract

The actin cytoskeleton is a structure found in all eukarytes, known to be essential for a wide range of cellular processes. Cytoskeletal dynamics is regulated by a large number of proteins, commonly known as actin-binding proteins. Althgouh the role of actin-binding proteins in somatic cells has been well studied, their function in germ cells remains unclear. The goal of this thesis is therefore to shed some light on the function of the actin cytoskeleton in sperm development, by investigating the possible funtion of the actin monomer binding protein profilin, and the actin-depolymerising factors.