Initially, the idea was to re-release the 2009 single "The Fields of Anfield Road" by The Liverpool Collective featuring The Kop Choir; however, this idea was rejected by Peter Hooton as only a relatively small number of people would buy it. Inspired by Everton's Hillsborough tribute on 17 September 2012, the song was played at Goodison Park prior to their match against Newcastle United. It was then decided that a re-recording of "He Ain't Heavy, He's My Brother" would be made by various artists including The Justice Tonight Band and released as the charity single.[2]

Keith Mullen of The Farm recruited Guy Chambers to produce the single and with Chambers offering free use of his Sleeper Studios to record the song. On 25 October, Steve Rotheram, Guy Chambers and Kenny Dalglish announced plans of the single to be recorded by various artists.