What key warnings should I know about before taking this medicine?

Reasons not to take this medicine

• If you have an allergy to tramadol or any other part of this medicine.

• Tell healthcare provider if you are allergic to any medicine. Make sure to tell about the allergy and how it affected you. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other symptoms involved.

• If you are addicted to drugs.

• If you are an alcohol drinker or take any alcohol-containing medicines.

How does it work?

How is it best taken?

• Take this medicine with or without food. Take with food if it causes an upset stomach.

• Ultram® ER: Always take with food or always take on an empty stomach.

• Long-acting products: Swallow whole. Do not chew, break, or crush.

•
Oral-disintegrating tablet:Do not push tablet through foil when opening. Use dry hands to remove from foil. Place on tongue and let dissolve. Water is not needed. Do not swallow whole. Do not chew, break, or crush.