IV: Omeprazole 40mg vial (powder) plus 10ml of specialised solvent Use only solvent provided for reconstitution as follows: 1. draw up 10ml of solvent from the ampoule 2. slowly add approximately 5ml of solvent to the vial 3. withdraw as much air as possible from the vial to reduce positive pressure 4. transfer the remaining solvent in to the vial 5. rotate and shake the vial to dissolve the powder

Inject solution over at least two and a half minutes at a rate not exceeding 4ml per minute Note: the omeprazole formulation available in the ICU cannot be given by infusion (see DOSAGE for recommendations) Store at room temperature Protect from light Prepare immediately before use. Reconstituted solution is stable at room temperature for four hours.

Omeprazole is a specific inhibition of the H+/K+ ATPase enzyme system at the secretory surface of the gastric parietal cell. Because this enzyme system is regarded as the acid (proton) pump within the gastric mucosa, omeprazole has been characterized as a gastric acid-pump inhibitor, in that it blocks the final step of acid production.

Omeprazole can prolong the elimination of diazepam, warfarin and phenytoin, drugs that are metabolized by oxidation in the liver. There have been reports of increased INR and prothrombin time in patients receiving proton pump inhibitors, including omeprazole, and warfarin concomitantly.