On 23 January 2016, at the 2016 Tour de San Luis, Malori suffered a severe crash as he was leading the peloton. His front wheel was caught in a crack on the road and he flew over his bike, crashing head-first. He was put in an induced coma.[4] Three days later, he was moved to a special clinic in Buenos Aires. Reports suggested that doctors had found the head trauma not to be a result, but rather the cause of the crash, citing a possible aneurysm.[5] However, the team discredited them soon afterward, saying a road defect was the cause of the crash.[6] In August, Malori announced that he would make his return to racing the following month at the Grand Prix Cycliste de Québec and Grand Prix Cycliste de Montréal.[7]

Malori announced his retirement from professional cycling on 10th July 2017, as a result of the injury.[8]