A cross-disease meta-GWAS identifies four new susceptibility loci shared between systemic sclerosis (SSc) and Crohn's disease (CD).
Through the first cross-disease meta-analysis of SSc and CD, we identified genetic variants with pleiotropic effects on two clinically distinct immune-mediated disorders. PubMed, Sci Rep. 2020 Feb 5;10(1):1862. (Also see Inflammatory Bowel Disease)
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Association of Psoriasis With Inflammatory Bowel Disease: A Systematic Review and Meta–analysis.
These findings suggest that psoriasis is significantly associated with IBD and gastroenterology consultation may be indicated when patients with psoriasis present with bowel symptoms. PubMed, JAMA Dermatol, 10/24/2018. (Also see Psoriasis and Psoriatic Arthritis and Inflammatory Bowel Disease)
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Risk of uveitis and inflammatory bowel disease in people with psoriatic arthritis (PsA): a population–based cohort study.
In a primary care–based incidence cohort of patients with PsA, there were substantial risks of developing uveitis and/or Crohn's disease, but not ulcerative colitis, when compared with the general population and psoriasis controls. PubMed, Ann rheumatologist Dis, 11/01/2017. (Also see Psoriasis and Psoriatic Arthritis and Inflammatory Bowel Disease)
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The current therapeutic options for Crohn's disease (CD): from medical therapy to intestinal transplantation.
CD treatment is mainly medical, leaving endoscopy and surgery for a complex course. PubMed, Expert Rev Gastroenterol Hepatol, 08/14/2017. (Also see Inflammatory Bowel Disease)
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