Bernard J Poiesz Michael J Poiesz and David Choi

and monoclonal T-cell lymphocytoses with HTLV-1 being skewed toward CD4+ lymphocytoses and HTLV-2 toward CD8+ lymphocytoses. HTLV-1 has been clearly established as the etiologic agent of intermediate to high-grade CD4+ T-cell non-Hodgkin's lymphoma and leukemia, whereas HTLV-2 has been increasingly associated with rare CD8+ T-lymphocytic malignancies. The discovery of HTLV-1 fulfilled the long search for a pathogenic human retrovirus and the understanding of its mechanisms of pathogenesis serves as a model for understanding human neoplasia.

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