There is increasing evidence of rapidly growing serious, pervasive, and expensive methamphetamine problem in Ïran in recent years - a malicious social phenomenon with widespread psychological, familial and economic adversities - which contributes to theft, murder, suicide, violence, and divorce. Substantial cases of acute psychiatric problems are increasingly seen following methamphetamine use in the emergency departments. Paranoid patients are more prominent. Many of these cases are characterized by anxiety, confusion, insomnia, mood disturbances, hallucinations, and out-of-control rages with extremely violent behavior and homicidal ideas. This serious tragedy which is one of the most important Ïranian society’s problems is called for effective multidimensional control policies.