As an overseas department of the French Republic, Guadeloupe is not a member of FIFA and is therefore not eligible to enter the FIFA World Cup or any competition organized first-hand by the organization. Guadeloupeans, being French citizens, are eligible to play for the France national football team. Guadeloupe is, however, a member of CONCACAF and the CFU and is eligible for all competitions organized by both organizations. Indeed, according to the status of the FFF (article 34, paragraph 6): "[...]Under the control of related continental confederations, and with the agreement of the FFF, those leagues can organize international sport events at a regional level or set up teams in order to participate to them."'

Guadeloupe's highest honor to date was reaching the final at the 2010 Caribbean Championship where they were defeated by Jamaica on penalties. In the CONCACAF Gold Cup, Guadeloupe reached the semi-finals in 2007. The team performed well in the group stage defeating Canada and drawing with Haiti. In the knockout stage of the competition, Guadeloupe eliminated Honduras in the quarterfinals. In the semi-finals, Guadeloupe lost to Mexico 1–0. The regional team also participates in the Caribbean Cup and the Coupe de l'Outre-Mer. Guadeloupe has yet to win either competition.

Guadeloupe was a surprise qualifier for the CONCACAF Gold Cup in 2007. The regional team earned qualification to the tournament after finishing in 4th place at the 2006–07 Caribbean Nations Cup. The appearance in the Gold Cup marked Guadeloupe's first in the competition and they opened the campaign on 6 June 2007 with a 1–1 draw against Haiti. In the team's following match against Canada, Guadeloupe recorded a 2–1 victory in front of 20,000 spectators at the Orange Bowl in Miami. The team finally succumbed to defeat losing 1–0 to the reigning champions of UNCAF, Costa Rica, to close out group play.

Guadeloupe advanced to the knockout stage of the competition as a result of being the best performing third-place team in group play. In the quarterfinals, Guadeloupe were pitted against Honduras and earned an upset victory defeating the Hondurans 2–1 at the Reliant Stadium in Houston.[2] Prior to its elimination, Honduras had been equal to the task of Guadeloupe having beaten Mexico 2–1 and dominating Cuba 5–0. In the ensuing round, Guadeloupe were defeated by Mexico 1–0.[3] However, despite the loss, Guadeloupe were praised for its strong defensive performance.[4] Guadeloupe's finish in the tournament was the best finish by a Caribbean island team since Trinidad and Tobago reached the semifinals of the 2000 tournament.

In the tournament, Guadeloupe were inserted to Group C alongside Mexico, Panama, and Nicaragua. The team started off the group with two straight victories defeating Panama 2–1 at the Oakland–Alameda County Coliseum and systematically disabling the Nicaraguans 2–0 at the Reliant Stadium in Houston. In the team's final group stage match against Mexico, Guadeloupe was beaten 2–0 in Phoenix. Guadeloupe's second-place finish in the group meant another appearance in the knockout stage, where the team was pitted against Costa Rica in the quarter-finals at Cowboys Stadium in Arlington, Texas. In the match, it was Costa Rica who dominated scoring twice within the first 20 minutes of the match. Costa Rica finished the match with five goals with Guadeloupe getting a consolation goal from Alphonse in the second half.

Guadeloupe has participated in three of the fourteen CONCACAF Gold Cups contested. The team's first appearance in the competition was in 2007. The team, surprisingly, reached the semi-finals where they were defeated by Mexico. Two years later, in 2009, Guadeloupe made their second consecutive appearance in the competition and, for the second straight time, reached the knockout stage of the Gold Cup. In the quarterfinals, Guadeloupe were defeated by Costa Rica.

Guadeloupe have appeared in seven Caribbean Cups. The regional team has yet to win the competition, but has finished in third place on three occasions in 1989, 1994, and 2008. Since the 2007 competition, Guadeloupe has finished inside the top four teams in the proceeding Caribbean Cups. In 2010, the team finished runner-up to Jamaica losing 5–4 on penalties.

Guadeloupe has participated in both editions of the Coupe de l'Outre-Mer, which was established in 2008. In both editions, the team finished in third place behind Martinique and Réunion with the latter team winning the first edition and Martinique winning the second.

From 1978–1985, Guadeloupe participated in the CFU Championship, a precursor to the Caribbean Cup. Of the six championships played, Guadeloupe featured in two final rounds and departed each tournament without a single win.