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Symptoms vary depending on the severity and location of the trauma; however, common symptoms include wrist drop (the inability to extend the wrist upward when the hand is palm down); numbness of the back of the hand and wrist; and inability to voluntarily straighten the fingers.

The term Saturday Night Palsy refers to nerve damage that can occur if a drunk person falls asleep with the back of their arms compressed by a bar edge, bench back, or like object. Radial neuropathy is also called honeymooners palsy, since it can be acquired by sitting with an arm draped over the back of a neighboring chair (or movie-theater seat) for a long time.

Both Saturday night palsy and honeymooners palsy refer to the fact that the nerve damage is generally forewarned by arm pain to a degree that only excessive love or liquor would drive a person to keep their arm in such an uncomfortable position.

Breaking the humerus and deep puncture wounds can also cause the condition.

Improperly sitting in a chair for several hours such that the armrest compresses the underside of the forearm is another potential cause.