Official Title

Summary:

Brachytherapy treatment in gynecological cancers is an essential component to delivering
adequate doses of radiation to a tumour while sparing normal tissue. Interstitial and
intracavitary brachytherapy is often needed in advanced or recurrent disease, in cases where
intrauterine brachytherapy may not deliver the optimal outcome. Interstitial brachytherapy is
based on a defined template-and-needle system, and the procedure relies on clinical
examination and pre-treatment imaging to guide needle insertion. There is currently no
standard image-guided process to help direct needles in the pelvis. The investigators propose
a 3D ultrasound device that will provide real-time imaging for the brachytherapy procedure
which will aid in avoiding needle insertion into pelvic organs and result in optimal dose
coverage to the tumour.

Trial Description

Primary Outcome:

Efficacy of the 3DUS device to visualize applicators

Secondary Outcome:

3DUS to CT Fusion

This is an efficacy study to optimize the use of three-dimensional ultrasound imaging for
interstitial and intracavitary brachytherapy. In this study, 3DUS images will be acquired
during the regular clinical procedure to assess the quality of the images, anatomical detail
and location of needles. The acquired images will be analyzed post-treatment and fused with
pre-treatment MRI, and post-treatment CT scans to develop a virtual simulated radiation
treatment plan, and to verify the applicator positions.