Fusion

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Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:query proteins and first shell of interactors

white nodes:second shell of interactors

Node Content

empty nodes:proteins of unknown 3D structure

filled nodes:some 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

mazG

Nucleoside-triphosphate pyrophosphatase (264 aa)

Predicted Functional Partners:

thyX

Thymidylate synthase; Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (234 aa)

0.903

nrdD

Ribonucleoside-triphosphate reductase (690 aa)

0.902

Acin_0783

Polysaccharide biosynthesis protein (517 aa)

0.868

mfd

Transcription-repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site (1093 aa)

0.868

era

GTP-binding protein era; An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (306 aa)

a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1

node2

node1 accession

node2 accession

node1 annotation

node2 annotation

score

Acin_0783

Acin_0785

Acin_0783

Acin_0785

Polysaccharide biosynthesis protein

Nucleoid DNA-binding protein; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions

0.698

Acin_0783

glpX

Acin_0783

Acin_0781

Polysaccharide biosynthesis protein

Fructose-1,6-bisphosphatase

0.558

Acin_0783

mazG

Acin_0783

Acin_0784

Polysaccharide biosynthesis protein

Nucleoside-triphosphate pyrophosphatase

0.868

Acin_0783

mfd

Acin_0783

Acin_0782

Polysaccharide biosynthesis protein

Transcription-repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site

0.864

Acin_0785

Acin_0783

Acin_0785

Acin_0783

Nucleoid DNA-binding protein; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions

Polysaccharide biosynthesis protein

0.698

Acin_0785

glpX

Acin_0785

Acin_0781

Nucleoid DNA-binding protein; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions

Fructose-1,6-bisphosphatase

0.439

Acin_0785

mazG

Acin_0785

Acin_0784

Nucleoid DNA-binding protein; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions

Nucleoside-triphosphate pyrophosphatase

0.704

Acin_0785

mfd

Acin_0785

Acin_0782

Nucleoid DNA-binding protein; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions

Transcription-repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site

0.729

Acin_1868

era

Acin_1868

Acin_0516

RNA methyltransferase

GTP-binding protein era; An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism

0.421

Acin_1868

mazG

Acin_1868

Acin_0784

RNA methyltransferase

Nucleoside-triphosphate pyrophosphatase

0.499

birA

era

Acin_0792

Acin_0516

biotin-(acetyl-CoA carboxylase) ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor

GTP-binding protein era; An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism

0.506

birA

mazG

Acin_0792

Acin_0784

biotin-(acetyl-CoA carboxylase) ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor

Nucleoside-triphosphate pyrophosphatase

0.511

era

Acin_1868

Acin_0516

Acin_1868

GTP-binding protein era; An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism

RNA methyltransferase

0.421

era

birA

Acin_0516

Acin_0792

GTP-binding protein era; An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism

biotin-(acetyl-CoA carboxylase) ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor

0.506

era

mazG

Acin_0516

Acin_0784

GTP-binding protein era; An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism

Nucleoside-triphosphate pyrophosphatase

0.857

era

nrdD

Acin_0516

Acin_0322

GTP-binding protein era; An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism

Ribonucleoside-triphosphate reductase

0.407

glpX

Acin_0783

Acin_0781

Acin_0783

Fructose-1,6-bisphosphatase

Polysaccharide biosynthesis protein

0.558

glpX

Acin_0785

Acin_0781

Acin_0785

Fructose-1,6-bisphosphatase

Nucleoid DNA-binding protein; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions

0.439

glpX

mazG

Acin_0781

Acin_0784

Fructose-1,6-bisphosphatase

Nucleoside-triphosphate pyrophosphatase

0.558

glpX

mfd

Acin_0781

Acin_0782

Fructose-1,6-bisphosphatase

Transcription-repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site

0.589

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Network Stats

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Functional enrichments in your networkNote: some enrichments may be expected here (why?)

Enrichment analysis is still ongoing, please wait ...

Statistical background

For the above enrichment analysis, the following statistical background is assumed: