No problems here either...
Looking at the posts (including KL forums), seems that the internal PDM/HIPS whitelist imploded for some users. MS signed applications shouldn't trigger PDM detections, nor KSN known/digitally signed programs such as Sandboxie.
Best course of action would be to log a support ticket and provide GSI and traces for the PDM detections.
Does this happen upon boot/login or regular work as well?