The largest collection of Madonna memorabilia ever will be auctioned Nov. 7 — including “the latex mask, waspie, gloves, bra and panties worn with Katy Perry for a 2014 V Magazine cover photo shoot (Estimate: $1,000-$4,000),” according to the catalog.

When I asked Madonna’s publicist Liz Rosenberg if it was creepy that someone would soon own her client’s panties, Liz replied, “If the shoe fits, then wear them in good health.”

She added that Madonna is currently in Europe and unaware that the auction is taking place.

Julien’s Auctions of Beverly Hills also has on the block negatives and prints of the nudes Bill Stone shot of Madonna in 1979, before she hit it big. Some of those images later appeared in Penthouse magazine.

Plus, there is the Marilyn Monroe-inspired scarlet dress, stole and jewelry worn in her “Material Girl” video (dress and stole estimate: $20,000 to $40,000) and costumes from “A League of Their Own,” “Evita” and “The Next Best Thing.”

Madonna, who is said to be worth $1 billion, isn’t hard up for cash and isn’t profiting from the auction.

“I do not believe any of what is being auctioned off was in Madonna’s possession,” Rosenberg said. “Designers often supply clothes for shoots that are then returned to the designers.”

Other lots have a more mysterious provenance, such as Madonna’s day planner/diary from 1988, including a handwritten appointment to appear on “Late Night With David Letterman,” and dates with then-husband Sean Penn (estimate: $2,000 to $4,000).

Maybe Penn himself would like to bid on a signed document relating to his separation from Madge (estimate: $1,000 to $2,000.) I wonder where that came from.