In the rabbits immunized with hourse serum and
ingested with small or large dcses of antituberculous
agents (SM., PAS. and INH,) Concurrently, the
appearence of pyroninophilic cells in the lyrnphnodes
and spleen was studied, and the following results were
obtained.
1) The lymphnodes and the spleen of the immunized
and concurrently ingested rabbits with small doses
of antituberculous drug revealed more pronounced
rise in the number of pyroninophilic cells than
simply immunized. This changes would be indicated
small doses of antituberculous drug ingestion enhancing
antibody formation.
2) The spleen and the lymphncdes of immunized and
concurrently ingested rabbits with large doses of
antituberculous drug showed decrease in the number
of pyroninophilic cells than the simply immunized.
This changes indicates large doses of antituberculous
drug ingestion impair antibody formation conclusively.
3) The spleen and lymphncdes of the rabbits which
are immunized and mean while injected with the
serum from rabbits which were ingested small doses
of .antituberculous drug showed more promoting
rising in number of pyroninophilic cells than the
simply immunized rabbits.
4) The spleen and lyrnphncdes of the rabbits which
were immunized and mean while injected with the
serum from rabbits which were ingested large doses
of antituberculous drug showed inhibiting decrease in
number of pyroninophilic cells than the simply
immunized rabbits.
5) According to previous studies it is seen that the
serum of small doses ingested antituberculous drug
rabbits contain on active producing factor which
promotes the appearence of pyroninophilic cells in the
spleen and lymphncdes of the immunized rabbits, and
that the serum of large doses ingested antitulerculous
drug rabbits contain on active producing factor
which inhibits the appearenes of the pyroninophilic
cells.