Re: Serzone and...- grapefruit/ anxiety/ + 2D6/3A4

Posted by Mendel on May 8, 1999, at 1:20:17

In reply to Serzone and...., posted by Elizabeth on May 5, 1999, at 23:47:43

Don't mean to sound like a dr. Preskorn wanna-be but it would make sense that the small % of people who get severe anxiety with nefazodone alone are probably genetically "poor 2D6 metabolizers." One way to possibly deal with this would be to systematically administer a glass of grapefruit juice prior to each dose of serzone as by inhibiting 3A4 you could theoretically block the conversion of nefazodone to MCPP.Elizabeth, how does smoking increase MCPP and are you a psychiatrist?