Available hosts

Available applications

Background of CABLES2 antibody

CABLES2 is a proapoptotic factor involved in both p53-mediated and p53-independent apoptotic pathways. ik3-1/CABLES1, a closely related molecule, has been identified to be a candidate tumor suppressor for colon and head/neck cancers.The exact function of this protein is unknown, but it is probably involved in G1-S cell cycle transition. CABLES2 binds to CDK3, CDK5 and ABL1.

Immunofluorescence analysis of A549 cells, using Ik3-2 Antibody. The picture on the right is treated with the synthesized peptide.