There was no evidence of compensatory upregulation of other DPP4 (show DPP4 Antibodies) family members in influenza-infected FAP-deficient mice. FAP appears to be dispensable in anti-influenza adaptive immunity.

FAP-STAT3 (show STAT3 Antibodies)-CCL2 (show CCL2 Antibodies) signaling in Cancer-associated fibroblasts (CAF (show LAMA2 Antibodies)) was sufficient to program an inflammatory component of the tumor microenvironment, which may have particular significance in desmoplasia-associated cancers.

Taken together, our study suggested that high FAP expression in CAFs (show TBX1 Antibodies) is one reason leading to immune checkpoint blockades resistance in CRC (show SCRIB Antibodies) patients and FAP is an optional target for reversing immune checkpoint blockades resistance.

FAP-vaccinated mice also treated with Cyclophosphamide chemotherapy showed a marked suppression of tumor growth (inhibition ratio =80%) and a prolongation of survival time.

In two different models of pulmonary fibrosis, intratracheal bleomycin instillation and thoracic irradiation, the study finds increased mortality and increased lung fibrosis in FAP-deficient mice compared with wild-type mice.

Mouse FGF-21 (show FGF21 Antibodies), however, lacks the FAP cleavage site and is not cleaved by FAP.

A transgenic mouse model for pulmonary fibrosis was generated. After bleomycin induction, luciferase cDNA under the control of the FAPa promoter presents strong luminescence in the lungs especially; the expression level reflects the degree of the disease.

The FAP(+) stromal cell may have roles in two adverse consequences of cancer.

In NIH 3T3 cells overexpressing recombinant mouse FAP, FAP enzymatic activity during matrix production is important for the topographical organization of the ECM (show MMRN1 Antibodies) fibers.

Fibroblast Activation Protein (FAP) Antigen Profile

Protein Summary

This gene belongs to the serine protease family. The encoded protein is an inducible cell-surface bound glycoprotein specifically expressed in tumor-associated fibroblasts and pericytes of epithelial tumors and has protease and gelatinase activity. The protein plays a role in remodeling of the extracellular matrix (ECM) and may affect tumorigenesis and tissue repair. Alternately spliced transcript variants of this gene are described in the literature (PMID 9139873), but the full-length sequence of these variants is not available.