A solid pseudopapillary tumor is a low-grade malignant cystic exocrine neoplasm of the pancreas of papillary architecture that typically afflicts young women with excellent postsurgical curative rates and rare metastasis. It may be locally aggressive. Pathological evaluation remains the gold standard in reaching a definitive diagnosis. We report a case of solid pseudopapillary neoplasm of the pancreas that was suspected on radiology and diagnosed preoperatively on biopsy guiding definitive surgery.