The Dipeptidyl Peptidases 4, 8, and 9 in Mouse Monocytes and Macrophages

Date: 10 October 2015

Introduction: Manuscript accepted for publication in Inflammation.

Waumans et al. have published their new findings on DPP4, 8 and 9 in a manuscript The Dipeptidyl Peptidases 4, 8, and 9 in Mouse Monocytes and Macrophages: DPP8/9 Inhibition Attenuates M1 Macrophage Activation in Mice.

Abstract
Atherosclerosis remains the leading cause of death in Western countries. Dipeptidyl peptidase (DPP) 4 has emerged as a novel target for the prevention and treatment of atherosclerosis. Family members DPP8 and 9 are abundantly present in macrophage-rich regions of atherosclerotic plaques, and DPP9 inhibition attenuates activation of human M1 macrophages in vitro. Studying this family in a mouse model for atherosclerosis would greatly advance our knowledge regarding their potential as therapeutic targets.