Summariesfor NOS1 gene

The protein encoded by this gene belongs to the family of nitric oxide synthases, which synthesize nitric oxide

from L-arginine. Nitric oxide is a reactive free radical, which acts as a biologic mediator in several processes,

including neurotransmission, and antimicrobial and antitumoral activities. In the brain and peripheral nervous

system, nitric oxide displays many properties of a neurotransmitter, and has been implicated in neurotoxicity

associated with stroke and neurodegenerative diseases, neural regulation of smooth muscle, including peristalsis,

and penile erection. This protein is ubiquitously expressed, with high level of expression in skeletal muscle.

Multiple transcript variants that differ in the 5' UTR have been described for this gene but the full-length

nature of these transcripts is not known. Additionally, alternatively spliced transcript variants encoding

different isoforms (some testis-specific) have been found for this gene.(provided by RefSeq, Feb 2011)

GeneCards Summary for NOS1 Gene:

NOS1 (nitric oxide synthase 1 (neuronal)) is a protein-coding gene. Diseases associated with NOS1 include factitious disorder, and pyloric stenosis. GO annotations related to this gene include calmodulin binding and heme binding. An important paralog of this gene is NOS3.