I’m not sure how I feel about this. All the disturbing practices he details are, well, disturbing. And not very scientific. However, he implies in his last sentence that the end goal to having well-structured data and documentation and source code in a version control tool is “reproducibility.” But there’s no offered definition of what “reproducibility” is.

This topic seems to come up a lot in the Open Science and Science 2.0 discussions. And the entry-level definition of “reproducibility” seems to be that another scientist or group will take your data and your tools and verify your result.

Sorry, but that’s not reproducibility. As the climate folks say, that’s replication. If you take all the same data and all the same tools, one of two things can happen:

You get a different result. That only shows that one of us is sloppy and shouldn’t be doing science.

You get the same result. That’s like plotting the same data point in two different colours and saying you’ve learned something.

There’s value in the first outcome, especially if you show I’m the sloppy one. I’m just not sure how much value there is. It’s going to be hard to convince some young researcher to take a year or five to figure out that maybe some other dude might be wrong. It’s just not that appealing. I’d rather work on my own ideas.

The real problem is that reproducibility or verification or whatever you want to call it is a lot harder than just running someone else’s code. It probably means designing a different experimental setup. Controlling for different biases. Getting a statistically independent data set. These things cost time and money, both of which are in short supply. But all these things are critical to say that a result has been reproduced.

A short example from my previous life. My thesis was about CP violation in the neutral kaon sector. We measured a parameter called Epsilon-prime. It doesn’t really matter what it is or what it describes. What mattered at the time was whether or not it had a value of zero. The Fermilab results said yes, consistent with zero, and the CERN results said no, it’s non-zero. A real “irreproducible” disagreement. And dammit, both groups had pride on the line and needed to be right.

So, both groups built new experiments. Both groups looked at each others techniques, and cherry-picked the best ideas. We went back for more funding. The second round of experiments got different results: now the Fermilab result was farther from zero than the CERN result. But by now, the two results were consistent within their respective uncertainties, and also consistent with a non-zero interpretation. That’s a win and reproducibility.

A similar thing is being reported in the New York Times from the DZero collaboration. No one is interested in looking at DZero’s data or their software. They are interested if the CDF collaboration has a similar, independent result that verifies what DZero is reporting.

This is going to be a bigger problem in the future, not just in physics, but also in bioinformatics. The scale of the data and the experiments is so large that no one will be able to mount a complementary experiment to confirm the results. Once the LHC produces peta- or yotta-bytes of data, that’s it. It’s all we got.

So in that respect, Brown’s points are good. You have to have decent data management plans. Scientists owe it to the people who will come later, and to the people (i.e. the taxpayer) who paid for the research. For some of these experiments will only be run once, and future scientists may have ideas to find stuff that we haven’t thought of yet. However, I’m not sure if he’s claiming it’s sufficient for reproducibility. I don’t think it is.

Now, none of this discussion is new; new to me maybe, but the climate folks have been alloverthis for a while. And it’s a really tough problem. I don’t have any answers, but the first step that the community is having is at least trying to figure out what the terms mean.

So, if you got this far, here’s the summary:

By all means, please make your data available after you publish your paper. In certain cases (LHC, bioinformatics) it’s all we got and we may need to look back at it for other stuff. Plus, since I paid for it with my taxes, I kinda feel I own a chunk of it anyway.

Make sure you write clean, tight code. Use version control and tests. Make your code available; not necessarily because I want to run it, but because it indicates to me that you’re confident in the code, and that I should be confident in your result.

But let’s drop the idea that I’m going to take your data and your code and “reproduce” your result. I’m not. First, I’ve got my own work to do. More importantly, the odds are that nobody will be any wiser when I’m done.