Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.

Preservative

No Preservative

Concentration

LYOPH

Purity

Immunogen affinity purified

Reconstitution Instructions

Reconstitute at 0.2 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for WASF1/WAVE1 Antibody

KIAA0269WAVEhomology of dictyostelium scar 1

Protein WAVE-1

SCAR1

SCAR1WASP family protein member 1

Verprolin homology domain-containing protein 1

WAS protein family, member 1

WASF1

WASP1

WAVE1

WAVE1FLJ31482

wisk

Background

WASF1/WAVE1 (Wiscott-Aldrich syndrome protein family Verprolin-homologous protein 1) is an 80‑85 kDa member of the SCAR/WAVE family of proteins. It is expressed in diverse cell types such as neurons, fibroblasts, macrophages, platelets, oligodendroglia and breast epithelium. WASF1/WAVE1 is normally inactive, being phosphorylated at Ser310 and complexed with HSPC300, PIR121 and Nap125. Upon activation, it is dephosphorylated and decoupled, heterodimerizes with WASP, and initiates actin polymerization. Human WASF1/WAVE1 is 559 amino acids (aa) in length. It contains five sequential poly-Pro regions (aa 278‑435) and one VPH domain (aa 497‑514) that binds to actin and Arp2/3. There is one isoform that shows a 23 aa N-terminal extension. In mouse, a 60 kDa proteolytic cleavage form is reported. Over aa 1‑250, human WASF1/WAVE1 shares 99% aa identity with mouse WASF1/WAVE1.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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