Block programming involves scheduling a series of related shows which are likely to attract and hold a given audience for a long period of time.[2] Notable examples of overt block programming were NBC's Thursday evening "Must See TV" lineup, which included two hours of sitcoms and one hour of ER, and Channel 4's "T4" program which often ran sitcoms like Friends back-to-back for an hour or more. Reruns on cable television are often assembled into similar blocks to fill several hours of generally little-watched daytime periods. A particularly long program block, especially one that does not air on a regular schedule, is known as a marathon.

Block programming in radio also refers to programming content that appeals to various demographics in time blocks, usually corresponding to the top or bottom of the hour or the quarter-hour periods. For example, various musical genres might be featured, such as a country music hour, a three-hour afternoon block of jazz, or a four-hour Saturday night '70s disco show.

Generally speaking, block programming is anathema to modern competitive commercial radio, which traditionally uses uniform formats, other than a handful of speciality shows in off-peak hours such as weekends (for instance, the infamous beaver hours in Canadian radio). The general rationale for not using block programming is that listeners expect a certain type of music when they tune into a radio station and breaking from that format will turn those listeners away from the station; likewise, a station that airs its programming in hodgepodge blocks will have difficulty building listener loyalty, as listeners' music will only be on for a few hours of the day. This argument for homogenized radio was also a driving force behind the effective death of freeform radio in the late 20th century. The case of talk radio is indicative of the decline of block programming: prior to the 1980s, it was not uncommon to mix various blocks of talk programming together on one station, but this has declined dramatically in the late 1990s and beyond. A listener to a conservative talk radio station will have little interest in a progressive talk radio, sports radio or hot talk block, which reaches a different demographic; stations that have attempted the block strategy have historically been unsuccessful. Block programming of this nature is alive and well on outlets like public radio (such as NPR, BBC, or the CBC) and in multicultural radio serving broad ethnic and cultural audiences, although even in this realm the idea of block programming is declining due to competition for donations.

Some programming blocks have become so popular that they have been transformed to full-fledged 24-hour channels. Current channels which started as program blocks include TeenNick (originally a program block on Nickelodeon);[3]Disney Junior (which is still a program block on the Disney Channel); Nick Jr. (which still airs on Nickelodeon); Boomerang (which was once a program block on Cartoon Network); and PBS Kids, a 24/7 channel, which PBS member stations are able to provide in addition to their current children's programming on the primary PBS channel.[4] In addition, TV Land airs older shows that were once aired on sister channel Nickelodeon's Nick at Nite program block.[5]