BLOOD VESSEL OR GRAFT PREPARATION

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600036000

BLOOD VESSEL OR GRAFT PREPARATION

56

20100191043

METHODS AND DEVICES FOR ISOLATING A VESSEL - A method of harvesting a target vessel includes creating a first incision, inserting a light source into a vessel through the first incision, the vessel located next to the target vessel, using the light source to illuminate a portion of the vessel, locating the target vessel from outside the vessel using the illuminated portion of the vessel, and dissecting at least a portion of the target vessel from surrounding tissue. A method that involves a target vessel includes inserting a light source into a vessel that is located next to the target vessel, providing light inside the vessel using the light source, and using light transmitted through a wall of the vessel to illuminate the target vessel or tissue next to the target vessel.

07-29-2010

20130197299

Unitary Endoscopic Vessel Harvesting Devices - Unitary surgical devices for tissue harvesting are disclosed. Such devices may include an elongated body extending between a proximal end and a distal end, and having one or more lumens extending through the elongated body and a tip disposed at the distal end of the elongated body. The harvesting device may further include a first gripping element disposed about the dissection tip and a second gripping element disposed about the dissection tip distally of the first gripping member. The second gripping member may be moveable with respect to the first gripping member for capturing a blood vessel between the first gripping member and the second gripping member. The blood vessel captured between first gripping member and the second gripping member may then be sealed and, subsequently, severed by a cauterizing element disposed between the first gripping member and the second gripping member.

08-01-2013

20160120173

Vessel Treatment Systems, Methods, and Kits - One aspect of the invention provides a vessel treatment system including: a housing defining at least one opening adapted and configured to receive an anatomical vessel; and a humidifier in communication with the housing, the humidifier adapted and configured to introduce humidity into the housing to prevent desiccation of the anatomical vessel. Another aspect of the invention provides a kit including: the vessel treatment system as described herein; and a passivation agent. Another aspect of the invention provides a method for preparing a vein graft. The method includes: applying a tissue passivation agent to a resected anatomical vessel; and placing the resected anatomical vessel in a humidified chamber while the tissue passivation agent cures.

05-05-2016

20120004499

Surgical Method for Performing a Coronary Blood Vessel Bypass - In accordance with one embodiment of the present disclosure, a surgical method may include making a first incision in a patient. The surgical method may also include receiving a gas from a source and humidifying and warming the gas received from the source. The surgical method may further include delivering the humidified and warmed gas into the first incision. The surgical method may further include separating one or more blood vessel branches from a blood vessel using at least one surgical instrument inserted through a second incision in the patient. The surgical method may further include removing a blood vessel segment from the patient through a third incision in the patient, wherein the blood vessel segment was in contact with the humidified and warmed gas delivered into the first incision prior to the removal.

Unitary Endoscopic Vessel Harvesting Devices - Unitary surgical devices are disclosed. Such devices may include an elongated body extending between a proximal end and a distal end, and having one or more lumens extending through the elongated body and a tip disposed at the distal end of the elongated body. The harvesting device may further include a first gripping element disposed about the dissection tip and a second gripping element disposed about the dissection tip distally of the first gripping member. The second gripping member may be moveable with respect to the first gripping member for capturing a blood vessel between the first gripping member and the second gripping member. The blood vessel captured between first gripping member and the second gripping member may then be sealed and, subsequently, severed by a cauterizing element disposed between the first gripping member and the second gripping member.

06-27-2013

20100168506

Method For Preparing Drug-Eluting Stent Having Nano-Structured Pattern - This invention relates to a method for preparing a drug-eluting stent using a chemical vapor deposition, the method comprising modifying the surface of a biodegradable polymer with nanostructures through a plasma-assisted chemical vapor deposition so as to improve drug-loading capability and drug elution rate.

07-01-2010

20100234678

BIOMIMETIC VASCULAR NETWORK AND DEVICES USING THE SAME - The invention provides method of fabricating a scaffold comprising a fluidic network, including the steps of: (a) generating an initial vascular layer for enclosing the chamber and providing fluid to the cells, the initial vascular layer having a network of channels for fluid; (b) translating the initial vascular layer into a model for fluid dynamics analysis; (c) analyzing the initial vascular layer based on desired parameters selected from the group consisting of a characteristic of a specific fluid, an input pressure, an output pressure, an overall flow rate and combinations thereof to determine sheer stress and velocity within the network of channels; (d) measuring the sheer stress and the velocity and comparing the obtained values to predetermined values; (e) determining if either of the shear stress or the velocity are greater than or less than the predetermined values, and (f) optionally modifying the initial vascular layer and repeating steps (b)-(e). The invention also provides compositions comprising a vascular layer for use in tissue lamina as well as a medical devices having a vascular layer and kits.

09-16-2010

20130345498

IMPLANTABLE PROSTHESIS WITH RADIOPAQUE PARTICLES AND METHOD OF MAKING SAME - An implantable prosthesis can comprise a strut having a lumen, radiopaque particles within the lumen, and a polymer binder. The polymer binder retains the radiopaque particles within the lumen. The strut may have side holes through which a therapeutic agent may pass and through which the radiopaque particles are incapable of passing. The polymer binder may be absent or optional. The radiopaque particles can have sizes that prevent them from escaping out of the lumen through the side holes. The radiopaque particles placed within the lumen can improve visualization of the prosthesis during an implantation procedure.

12-26-2013

20110190572

Methods and Compositions for Vein Harvest and Autografting - The leading cause of graft failure is the subsequent development of intimal hyperplasia, which represents a response to injury that is thought to involve smooth muscle proliferation, migration, phenotypic modulation, and extracellular matrix (ECM) deposition. Surgical techniques typically employed for vein harvest—stretching the vein, placing the vein in low pH, solutions, and the use of toxic surgical skin markers—are shown here to cause injury. The invention therefore provides for non-toxic surgical markers than also protect against stretch-induced loss of functional viability, along with other additives. Devices and compositions for reducing physical stress or protecting from the effects flowing therefrom, also are provided.

08-04-2011

20130338432

Fabric Cutting System and Method - A fabric cutting system and/or method can include a mandrel having a body and first and second legs, a centered chuck, and an offset chuck, each chuck configured to receive either one of the legs or body to rotatingly support the mandrel between the chucks. When one of the legs is inserted into the centered chuck and the mandrel body is inserted into the offset chuck, the mandrel can be rotated and the fabric mounted on the mandrel can be cut about the leg at a location beyond the end of the other leg. One of the legs can include a leg extension removable from a leg base that when removed allows the other leg to be cut beyond the end of the leg base. The fabric can be cut with a cutting laser, which may be a multi-axis laser, and/or have low power.

12-19-2013

20120310041

Percutaneously Implantable Replacement Heart Valve Device and Method of Making Same - A method of making a replacement heart valve device whereby a fragment of biocompatible tissue material is treated and soaked in one or more alcohol solutions and a solution of glutaraldehyde. The dried biocompatible tissue material is folded and rehydrated in such a way that forms a two- or three-leaflet/cusp valve without affixing of separate cusps or leaflets or cutting slits into the biocompatible tissue material to form the cusps or leaflets. After the biocompatible tissue material is folded, it is affixed at one or more points on the outer surface to the inner cavity or a stent.

12-06-2012

20130345499

SIDE TO SIDE ANASTOMOSIS - The invention relates to an assembly comprising on the one hand a graft vessel and on the other hand an anastomosis has connector. The connector comprises a ring and two pins. Each pin has a free end and a fixed end connected to the ring. The pins extend, viewed from the fixed end towards the free end, next to and set apart from each other. Each pin has an overlap section where the pin, viewed in axial direction of the ring, overlaps the plane bounded by the outer contour of the ring. The axial axis of the ring extends transverse to the wall of the graft vessel. The connector is attached to the graft vessel and the ring lies, with its full circumference, against the wall of the graft vessel. The invention further relates to a method of providing such an assembly and a method of attaching such an assembly to a recipient vessel.

12-26-2013

20110124958

DEVICE AND METHOD FOR EXTRACTING TUBULAR STRUCTURES - A device and method for extracting tubular structures are provided. An incision is made at a proximate and at a distal end of a tubular structure. An extracting device is inserted into and passed through a tubular structure until the operational head of the device extends past the distal incision. An actuator on the handle of the device is actuated, longitudinally extending the operational head of the device. The edge of a tubular structure is positioned axially in the mouth of a hook wire on the operational head. The actuator on the handle is released and the hook wire engages and captures the tubular structure. The user manually pulls the tubular structure, invaginating and removing it.

05-26-2011

20100160718

Apparatus and Method for Mounting an External Scaffold to a Vascular Graft - A method for securing a compliant scaffold to an outer surface of a vascular graft includes positioning the scaffold radially about an elongated support tube which includes first and second radially outwardly flared end portions respectively defining first and second open ends of the support tube. The method further includes pulling the vascular graft through a lumen of the support tube, and axially deploying the scaffold over the first end portion of the support tube and into compliant contact with the outer surface of the vascular graft.

06-24-2010

20140323800

VESSEL DISSECTION AND HARVESTING APPARATUS, SYSTEMS AND METHODS - Apparatus, systems, and methods for endoscopic dissection of blood vessels and control over cavity pressure within an endoscopic procedure are described herein. Apparatus, systems, and methods for harvesting of blood vessels are also described herein.

10-30-2014

20140296622

Blood Vessel Marking System - Apparatus for marking a blood vessel for use as a bypass graft in a patient includes a preparation plate for supporting an isolated blood vessel that is in a state for anastomosing to the patient. A stencil plate is configured for overlying the blood vessel and preparation plate, wherein the stencil plate has an opening adapted to expose a portion of the blood vessel to a dye applied through the opening. The stencil plate around the opening is adapted to shield the blood vessel from the dye. A dye applicator is configured to direct a metered amount of the dye through the opening and onto the exposed portion of the blood vessel, preferably as a mist. Preferably, the opening is a lineal slot for creating a guide line extending longitudinally along an outer wall of the blood vessel.

10-02-2014

20150342604

SOFT TISSUE GRAFT PREPARATION DEVICES AND METHODS - A soft tissue graft preparation device includes a handle portion, a body portion extending distally from the handle portion, and an end effector operatively connected to a distal end of the body portion. The end effector includes first and second members. The soft tissue graft preparation device also includes a filamentous material attachment structure that includes at least one filamentous material attached thereto, wherein the filamentous material attachment structure is placed in longitudinal juxtaposition to a tissue contacting surface of the first member and/or a tissue contacting surface of the second member.

VEIN HARVESTING SYSTEM AND METHOD - A tissue illumination system and a method for harvesting a section of a blood vessel from a patient's body for further use. The tissue illumination system includes a light catheter inserted into a lumen of the blood vessel section to illuminate the vessel section and vessel side branches with an intensity which is visible to the physician from an exterior of the vessel section and also includes a viewing element insertable into the lumen and capable of viewing the illuminated vessel section. The tissue illumination system also includes at least one tool insertable into the lumen and used to harvest the vessel section.

12-18-2014

20150073207

SINGLE-PASS ENDOSCOPIC VESSEL HARVESTING - An endoscopic harvesting device removes a vessel from a body. The vessel has an anterior side closest to the skin. A sheath extends in a longitudinal direction with a dissector tip for advancing along the vessel substantially along the anterior side to create a flanking tunnel spaced away from the vessel. A ring-shaped blade is mounted to the sheath and is disposed in a plane substantially perpendicular to the longitudinal direction and proximal of the dissector tip. The blade forms a lateral loop to encircle the vessel from the flanking tunnel and to make a vasiform cut including a pedicle around the vessel as the sheath advances.

03-12-2015

20130317285

Apparatus for Creating Graft Devices - An apparatus is provided for applying a restrictive fiber matrix to a conduit to create a graft device. A rotating assembly rotates the conduit, and a polymer delivery assembly delivers the restrictive fiber matrix. A controller controls the polymer deliver assembly and the rotating assembly.

11-28-2013

20130102839

Methods for Making a Supported Graft - A method for preparing a stent-graft for intraluminal delivery, including positioning an expanded polytetrafluoroethylene (ePTFE) substrate over a support mandrel, coupling a shape memory member to a polymer cladding to form a polymer clad member, winding the polymer clad member in an overlapping helical manner onto a surface of the ePTFE substrate, joining and sealing adjacent overlapping regions of the polymer clad member together and to the surface of the ePTFE substrate to form a stent-graft, manipulating the stent-graft from a larger first diameter to a smaller second diameter, and loading the stent-graft into a restraining sheath at the smaller second diameter.

04-25-2013

20130012767

SYSTEMS, DIES, AND METHODS FOR PROCESSING PERICARDIAL TISSUE - Systems, dies, and methods are provided for processing pericardial tissue. The method includes positioning a die-cut assembly over the pericardial tissue, the die-cut assembly including a die having a plate, a die pattern, and an opening, the die pattern attached to the plate, the opening formed in the plate to provide access to the pericardial tissue, and measuring a thickness of the tissue through the opening. The die-cut assembly may be mounted for automated vertical movement, and a platen on which the tissue is placed is capable of automated horizontal movement. Different target areas on the tissue can be assessed by measuring the thickness through the die, and when an area is deemed suitable the die pattern cuts a shape therefrom. The system is useful for cutting uniform thickness heart valve leaflets, and can be automated to speed up the process.

01-10-2013

20150351902

PERCUTANEOUSLY IMPLANTABLE REPLACEMENT HEART VALVE DEVICE AND METHOD OF MAKING SAME - A method of making a replacement heart valve device whereby a fragment of biocompatible tissue material is treated and soaked in one or more alcohol solutions and a solution of glutaraldehyde. The dried biocompatible tissue material is folded and rehydrated in such a way that forms a two- or three-leaflet/cusp valve without affixing of separate cusps or leaflets or cutting slits into the biocompatible tissue material to form the cusps or leaflets. After the biocompatible tissue material is folded, it is affixed at one or more points on the outer surface to the inner cavity or a stent.

12-10-2015

20130018220

METHOD FOR ELECTROSPINNING A GRAFT LAYER - A method for making a graft layer is provided. The graft layer has at least two layers with different porosities. The two layers are applied by electrospinning. The parameters of the electrospinning may be varied when applying the first and second layers in order to achieve different porosities of the first and second layers.

01-17-2013

20120078037

VESSEL HARVESTER - Apparatus and method for harvesting selected vessels in the body of a patient include manual manipulation of a rigid dissecting endoscope and the reconfiguration thereof to facilitate tissue dissection and tissue dilation in the formation of an anatomical space about the vessel within which side-branch vessels may be manipulated in preparation for severance and removal of the vessel from the anatomical space.

Bypass Configuration and Method of Construction - A method for constructing a vascular connector configured to bypass an occluded vessel which comprises a primary graft stem and a venous outflow stem. In general, the primary graft stem accepts a blood flow from an occluded vessel to bypass the occlusion. The venous outflow stem may extend from a wall of the primary graft stem and divert a portion of the blood flow to a native vein or other vessel of the vascular system. This configuration is beneficial in ensuring adequate blood flow at the vascular connector to inhibit the formation of clots and to extend the patency of the vascular connector.

BLOOD VESSEL GRAFTS FOR REPAIR, RECONSTRUCTION AND FILLER MATERIALS - Compositions comprising aortic material and methods for using harvested blood vessels (e.g., arteries or veins e.g., aortae) graft procedures, e.g., for restoring and repairing luminal structures (e.g., in the aerodigestive tract, such as the larynx, pharynx, and esophagus); as tissue fillers (e.g., injectable morselized blood vessel tissues, for use in cosmetic applications and functional sphincter enhancement); and as biological structural supports (e.g., intact portions of aortae, for use in repairing abdominal wounds, anastomoses, bony repairs, and the heart).

11-14-2013

20120108891

VEIN HARVESTING SYSTEM AND METHOD - A tissue illumination system and a method for harvesting a section of a blood vessel from a patient's body for further use. The tissue illumination system includes a light catheter inserted into a lumen of the blood vessel section to illuminate the vessel section and vessel side branches with an intensity which is visible to the physician from an exterior of the vessel section and also includes a viewing element insertable into the lumen and capable of viewing the illuminated vessel section. The tissue illumination system also includes at least one tool insertable into the lumen and used to harvest the vessel section.

05-03-2012

20130158342

PHOTOCHEMICAL TISSUE BONDING - Photochemical tissue boding methods for bonding neural tissues include the application of a photosensitizer to a tissue and/or tissue graft, followed by irradiation with electromagnetic energy to produce a tissue seal. The methods are useful for tissue adhesion, such as in wound closure, tissue grafting, skin grafting, musculoskeletal tissue repair, ligament or tendon repair, neural repair, blood vessel repair and corneal repair.

06-20-2013

20150359630

SYSTEMS AND METHODS FOR ENDOLUMINAL VALVE CREATION - Medical systems, devices and methods for creation of autologous tissue valves within a mammalian body are disclosed. One example of a device for creating a valve flap from a vessel wall includes an elongate tubular structure having a proximal portion and a distal portion and a longitudinal axis; a first lumen having a first exit port located on the distal portion of the elongate tubular structure; a second lumen having a second exit port located on the distal portion of the elongate tubular structure; a recessed distal surface on the distal portion of the elongate tubular structure, wherein the recessed distal surface is located distally to the first exit port; and an open trough on the recessed distal surface extending longitudinally from the first exit port.

12-17-2015

20140058194

System and Mandrel for Creating Graft Devices - A system for applying a fiber matrix on a tubular member is provided. A mandrel, configured for atraumatic placement within the tubular member, is included. Methods for atraumatic placement of a mandrel into a tubular member are also provided.

METHOD FOR MAKING A FLEXIBLE STENT-GRAFT - A method of making a stent-graft is provided. The method includes mounting a stent on a mandrel so that the stent is stretched when it is on the mandrel. A graft layer is then adhered to the stent while it is mounted on the mandrel. When the stent-graft is removed from the mandrel, the stent contracts and the graft layer becomes partially wrinkled when the stent is in its expanded relaxed state.

10-11-2012

20110224483

VEIN HARVESTING SYSTEM AND METHOD - A tissue illumination system and a method for harvesting a section of a blood vessel from a patient's body for further use. The tissue illumination system includes a light catheter inserted into a lumen of the blood vessel section to illuminate the vessel section and vessel side branches with an intensity which is visible to the physician from an exterior of the vessel section and also includes a viewing element insertable into the lumen and capable of viewing the illuminated vessel section. The tissue illumination system also includes at least one tool insertable into the lumen and used to harvest the vessel section.

09-15-2011

20110130624

SYSTEM AND METHOD FOR ATTACHING A VESSEL IN A VASCULAR ENVIRONMENT - An apparatus is provided in one example embodiment and includes a body section having an upper surface, a lower surface, and an inner edge circumferentially arranged around at least a portion of an open area. The apparatus also includes a tool extending from the body section into the open area for holding a graft vessel. The lower surface of the body section opposes a receiving vessel when the tool is positioned to transfer the graft vessel to the receiving vessel, such that the graft vessel is axially accessible through the open area to be attached to the receiving vessel. In more specific embodiments, the body section has first and second opposing ends defining a gap sized to permit the vessel to pass through.

06-02-2011

20110288369

SURGICAL INSTRUMENT AND METHOD - An actuator for use in a surgical instrument, the actuator includes an upper portion configured to be actuated by one or more fingers, wherein the upper portion has an upper distal portion for operating the surgical instrument in a first mode of operation, and an upper proximal portion for operating the surgical instrument in a second mode of operation, and wherein the upper distal portion and the upper proximal portion have different respective tactile configurations for informing the user of the first and second modes of operation, respectively.

11-24-2011

20090023981

VEIN HARVESTING SYSTEM AND METHOD - A tissue illumination system and a method for harvesting a section of a blood vessel from a patient's body for further use. The tissue illumination system includes a light catheter inserted into a lumen of the blood vessel section to illuminate the vessel section and vessel side branches with an intensity which is visible to the physician from an exterior of the vessel section.

01-22-2009

20080228028

WOVEN FABRIC WITH SHAPE MEMORY ELEMENT STRANDS - The disclosure relates to a woven fabric for use in an implantable medical device. The woven fabric comprises shape memory element strands woven with textile strands. At least one of the shape memory element strands has at least one float of at least five textile strands between binding points.

09-18-2008

20090030269

CELL-FREE TISSUE REPLACEMENT FOR TISSUE ENGINEERING - The present invention is a natural, cell-free tissue replacement that does not require difficult or extensive preparation made by washing tissue replacement in a solution including one or more sulfobetaines and an anionic surface-active detergent and washing the tissue replacement in serial solutions of the buffered salt to remove excess detergent. The natural, cell-free tissue replacement may be a nerve graft that supports axonal regeneration, guides the axons toward the distal nerve end and/or is immunologically tolerated. Other forms of the invention are a composition and kit prepared by the method of making a native, cell-free tissue replacement. The present invention may be modified for use in diagnostic, therapeutic, and prophylactic applications.

01-29-2009

20090112053

Blood Vessel Preparation and Preservation Kit - A vessel preparation and preservation kit supports a blood vessel during processing for use in bypass graft surgery. The device comprises a clamshell base having first and second trays latchable in a closed condition and pivotable to an open condition. The first tray has a series of open slots on an interior surface, wherein each slot extends substantially transverse to the longitudinal axis of the clamshell base. A first fixture has a first plate positionable in any selected one of the slots, a first fitting for holding a first end of the blood vessel, and a fluid supply needle for inserting into the first end of the blood vessel. A second fixture has a second plate positionable in any selected one of the slots a predetermined distance from the first fixture and having a second fitting for holding a second end of the blood vessel. A liquid-retaining foam is mounted in the second tray to immerse the prepared blood vessel in liquid to preserve it by putting the trays in the closed condition.

04-30-2009

20090018386

Seeding Implantable Medical Devices with Cells - The invention is directed to apparatus and methods for seeding an implantable medical device, such as a vascular prosthesis, with cells, such as endothelial cells. The invention supports techniques for seeding a luminal surface of the device with axial centrifugation. Cells are introduced in suspension into the lumen of the device, and the device is subjected to centrifugation around a longitudinal axis defined by the lumen. Axial centrifugation causes the cells to concentrate toward the luminal surface. Shortly after axial centrifugation, the seeded device can be presented for implantation in a patient.

01-15-2009

20080255408

SYSTEMS AND METHODS OF PROMOTING ENDOTHELIALIZATION OF A HYBRID LOWER LIMB ARTERY BYPASS VASCULAR GRAFT IN A MAMMAL - Hybrid synthetic grafts and embodiments of systems and methods for producing hybrid vascular grafts that can yield implantable grafts that combine synthetic grafts with living cells. Embodiments of systems can include a pressure/flow loop subsystem having an external flow loop system coupled to a specimen holder, where the pressure/flow loop subsystem is capable of adjusting at least two dynamic conditions in the specimen holder or a diameter of a specimen in the specimen holder. Embodiments of methods can promote endothelialization of a hybrid lower limb artery bypass vascular graft by placing the hybrid lower limb artery bypass vascular graft in a system embodiment according to the invention under conditions effective to promote stem cells to form a confluent monolayer on the hybrid vascular graft.

HYBRID CAROTID BYPASS GRAFTS AND SYSTEMS AND METHODS FOR PRODUCING OR MODIFYING THE SAME - Hybrid synthetic grafts and embodiments of systems and methods for producing hybrid vascular grafts that can yield implantable grafts that combine synthetic grafts with living cells. Embodiments of systems include a pressure/flow system having an external flow loop system for generating a flow loop, a specimen having a region arranged in the flow loop, and a controller, where the pressure/flow system is capable of adjusting at least two dynamic conditions at the region or a diameter of the specimen. Embodiments of methods can prepare a hybrid carotid bypass graft intended for implantation into a mammal by placing the hybrid carotid bypass graft in a system embodiment according to the invention prior to implantation of the hybrid carotid bypass graft into the mammal.

10-09-2008

20080242922

HYBRID HEMODIALYSIS ACCESS GRAFTS OR A HYBRID FEMORAL ARTERY BYPASS GRAFT AND SYSTEMS AND METHODS FOR PRODUCING OR MODIFYING THE SAME - Hybrid synthetic grafts and embodiments of systems and methods for producing hybrid vascular grafts that can yield implantable grafts that combine synthetic grafts with living cells. Embodiments of systems can include a pressure/flow loop subsystem having an external flow loop system coupled to a specimen holder, where the pressure/flow loop subsystem is capable of adjusting at least two dynamic conditions in the specimen holder or a diameter of a specimen in the specimen holder. Embodiments of methods can prepare a hybrid hemodialysis access graft or a hybrid femoral artery bypass graft intended for implantation into a mammal by placing the hybrid graft in a system embodiment according to the invention prior to implantation of the hybrid graft into the mammal.

10-02-2008

20080242923

SYSTEMS AND METHODS OF COATING A HYBRID HEMODIALYSIS ACCESS GRAFT OR A HYBRID FEMORAL ARTERY BYPASS GRAFT IN A MAMMAL - Hybrid synthetic grafts and embodiments of systems and methods for producing hybrid vascular grafts that can yield implantable grafts that combine synthetic grafts with living cells. Embodiments of systems can include a pressure/flow loop subsystem having an external flow loop system coupled to a specimen holder, where the pressure/flow loop subsystem is capable of adjusting at least two dynamic conditions in the specimen holder or a diameter of a specimen in the specimen holder. Embodiments of methods can coat a hybrid hemodialysis access graft or a hybrid femoral artery bypass graft with a confluent monolayer of endothelial cells by immobilizing a plurality of endothelial cells on the hybrid hemodialysis access graft or the hybrid femoral artery bypass graft and placing the hybrid graft in a system embodiment according to the invention under conditions effective to promote the endothelial cells to form a confluent monolayer on the hybrid graft.

10-02-2008

20080242920

Method of conditioning a hybrid synthetic tubular structure to yield a functional human hybrid coronary bypass graft - A method of yielding a functional human hybrid coronary bypass graft is provided. The method includes conditioning a hybrid synthetic tubular structure having stem cells and/or endothelial cells on at least one surface to yield the functional human hybrid coronary bypass graft. Specifically, the method includes placing the hybrid synthetic tubular structure in a system capable of producing three dimensional dynamic conditions for a sufficient time to yield said functional human hybrid coronary bypass graft.

10-02-2008

20080242921

SYSTEMS AND METHODS OF PROMOTING ENGRAFTMENT OF A HYBRID HEMODIALYSIS ACCESS GRAFT OR A HYBRID FEMORAL ARTERY BYPASS GRAFT IN A MAMMAL - Hybrid synthetic grafts and embodiments of systems and methods for producing hybrid vascular grafts that can yield implantable grafts that combine synthetic grafts with living cells. Embodiments of systems can include a pressure/flow loop subsystem having an external flow loop system coupled to a specimen holder, where the pressure/flow loop subsystem is capable of adjusting at least two dynamic conditions in the specimen holder or a diameter of a specimen in the specimen holder. Embodiments of methods can promote engraftment of a hybrid hemodialysis access graft or a hybrid femoral artery bypass graft following implantation into a mammal's body by placing the hybrid hemodialysis access graft or the hybrid femoral artery bypass graft in a system embodiment according to the invention prior to implantation of the hybrid graft into the mammal's body.

10-02-2008

20080234540

Osteochondral Implant Procedure - A surgical procedure according to which a moldable material is positioned over a defect and over an area of the anatomy surrounding the defect so that the moldable material takes the shape of the area. After the moldable material forms a mold, a graft is placed on the mold; and cut to conform to a dimension of the defect.

09-25-2008

20080234542

SYSTEMS AND METHODS OF COATING A HYBRID LOWER LIMB ARTERY BYPASS VASCULAR GRAFT IN A MAMMAL - Hybrid synthetic grafts and embodiments of systems and methods for producing hybrid vascular grafts that can yield implantable grafts that combine synthetic grafts with living cells. Embodiments of systems can include a pressure/flow loop subsystem having an external flow loop system coupled to a specimen holder, where the pressure/flow loop subsystem is capable of adjusting at least two dynamic conditions in the specimen holder or a diameter of a specimen in the specimen holder. Embodiments of methods can coat a hybrid graft with a confluent monolayer of endothelial cells by immobilizing stem cells on a hybrid lower limb artery bypass vascular graft, placing the hybrid graft in a system embodiment according to the invention under conditions effective to promote the stem cells to form a confluent monolayer on the surface of the hybrid vascular graft and in an environment to promote the stem cells to differentiate into endothelial cells.

09-25-2008

20080234541

SYSTEMS AND METHODS OF PROMOTING ENDOTHELIALIZATION OF A HYBRID CAROTID BYPASS VASCULAR GRAFT IN A MAMMAL - Hybrid synthetic grafts and embodiments of systems and methods for producing hybrid vascular grafts that can yield implantable grafts that combine synthetic grafts with living cells. Embodiments of systems can include a pressure/flow loop subsystem having an external flow loop system coupled to a specimen holder, where the pressure/flow loop subsystem is capable of adjusting at least two dynamic conditions in the specimen holder or a diameter of a specimen in die specimen holder. Embodiments of methods can promote endothelialization of a hybrid carotid bypass vascular graft by placing the hybrid carotid bypass vascular graft in a system embodiment according to the invention under conditions effective to promote endothelial cells to form a confluent monolayer on the surface of the hybrid vascular graft.