Diamond Blackfan anemia is rare congenital anemia that belongs to the inherited BM failure syndromes, generally presenting the first years of life. The onset mechanisms of the disease are widely unknown, even though progresses have been made by the analyses using various analytical methods such as gene manipulating technologies. Recently, the technology to prepare iPS cells from blood of patients has been established. These cells have the same genetic background with the patients. In this study, 4 strains of DBA-derived iPS cells were established from Japanese patients. Also, I found that the down-regulation of erythroid specific cell surface maker is closely related to the activation of intracellular metabolism including autophagy.