Main Interests:

Our research relies in the hypothesis that brain dysmetabolism is an underlying cause of neurodegenerative diseases such as Parkinson’s or Alzheimer’s.
Epidemiological findings suggest that dysmetabolism such as in Diabetes is an important risk factors for neurodegenerative diseases. Importantly, we identified that protein glycation, a major consequence of hyperglycemia, is a molecular link between these disorders. Therefore, we are focused in understanding how sugar stress potentiates neurodegeneration. This will ultimately allow to identify novel therapeutic targets for brain diseases.

Research Areas:

Our primary questions are:
1. What is the impact of diabetes (hyperglycemia) in brain diseases?
2. What are the effects of dysbiosis in Parkinson’s disease?
3. Are glycation defenses putative therapeutic agents for Parkinson’s disease?
4. What are the major proteome response mechanisms to glycation in models of brain diseases?