If a patient has HIV, consider Kaposi's sarcoma and make an urgent referral if suspected

Urgent Investigation

Urgently investigate increasing, unexplained or persistent bone pain or tenderness, particularly pain at rest (and especially if not in the joint), or an unexplained lump. In older people, metastases, myeloma or lymphoma, as well as sarcoma, should be considered. Refer under Two-Week Wait if positive