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There are a number of well-read (and well published) posters here. I am wondering if any of you know what the most common cause of equivocal reactions that come upon during antibody ID? You know, the often weak reactions that are left over after all of the rule-outs are accomplished?
Some are apparently the result of HLA interactions, but are most just junk reactions with otherwise unnamed insignificant antigens? More importantly, how many are actually "developing" antibodies to significant antigens? We do see, over time, patients pop up with only a few equivocals, and after a few transfusions, develop a full response to a significant antigen. I was just wondering if there is any data on how commonly this occurs.
Thanks, Scott

We are considering using the edit function on Neo to manually review and interpret equivocal reactions on antibody screen tests performed on Neo. We have been getting many, many equivocals over the past several months and all instrument and reagent solutions are temporary. We are repeating a significant number of tests which is requiring extra resources of reagent and time, not to mention delay to patients. All of the antibody screen repeat test results are negative so we are looking into thoughtfully editing the Neo result.
Is anyone routinely using the Edit feature and what is your algorithm for interpretation?
Thanks!