“Two Machines Similarly Constructed”: Humanity Between Apes and Clones explores the development of scientific taxonomies of difference and the proliferation and evolution of the definition of the “human.” A focus on Enlightenment...

Females are more susceptible to autoimmune disease than males. In several mouse models of disease, castration of males exacerbates disease while androgen treatment ameliorates disease. These data suggest hormones can have an influence on disease...

c-Myc dysregulation is one of the most common abnormalities found in human cancer. MicroRNAs (miRNAs) are functionally intertwined with the c-Myc network as multiple miRNAs are regulated by c-Myc, while others directly suppress c-Myc expression. In...

Peer-to-peer networks have been growing in popularity over the past decade. There have been many new innovations that greatly improve access to a wide variety of content. This expanded capability combined with a strong sense of anonymity has given...

Wounds care and management is one of the most basic needs in the medical setting. Burn wounds, trauma wounds, pressure ulcers and bedsores are just some of the many types of wounds that need to be treated quickly and efficiently. Take for instance...

This work presents a novel comprehensive effort to understand the fluid dynamics within orbiting dishes and the effects of the resulting oscillating fluid flow on shear and endothelial cellular responses within the dishes. It is well documented...

Human adult olfactory epithelium contains neural progenitors (hONPs) which replace damaged cellular components throughout life. Methods to isolate and expand the hONPs have been developed in our laboratory. In response to morphogens, the hONPs...

Chronic inflammation promotes a variety of cancers but inflammation also plays an important role in immune surveillance of cancer. Chemokine decoy receptor, D6 scavenges large number of inflammatory chemokines without transducing any signals and...

Oxidative stress-induced immunosuppression could be due to a decrease in CD4 + T lymphocyte activation or proliferation. 4-Hydroxynonenal (HNE), an end product of lipid peroxidation, and its protein adducts act as markers of oxidative stress. In...

Autism Spectrum Disorders (ASD) are a group of conditions characterized by a broad spectrum of deficiencies related to social communication, both verbal and non-verbal, as well as repetitive behaviors such as rocking back and forth, or arm...

Fibroblast growth factor (FGF)-1 was found to protect the heart from oxidative damage, but clinically its long-term use was restricted for its undesirable proliferating activity on cells. Thus a cluster of amino acids responsible for the...

The following dissertation was aimed at characterizing the metabolic disruptions that occur with selenite treatment in human lung cancer. Specifically, the pathways of glycolysis, TCA cycle, nucleotide metabolism, pentose phosphate pathway,...

Non-small cell lung cancer (NSCLC) is the number one cause of cancer-related death and, like all cancers, requires metabolic reprogramming to support the energetic and biosynthetic demands of the tumor cells to proliferate and survive the tumor...

In today's market customers are increasingly demanding a greater number of options in the products they purchase. Offering products in greater variety helps industries cater to a wider range of customers. However, at the same time, this product...

Pituitary tumor transforming gene ( PTTG ), also known as securing, is a novel oncogene that is expressed at high levels in most of the tumors analyzed to date. Overexpression of PTTG in mouse fibroblast(NIH 3T3) cells increases cell proliferation,...

Vascular injury and chronic arterial diseases such as atherosclerosis and restenosis result in exposure of vascular smooth muscle cells (VSMCs) to increased concentrations of growth factors triggering a change from a contractile to a synthetic...

Chlorine is a widely used toxic chemical that is considered a chemical threat agent. Chlorine inhalation injures airway epithelium, and efficient epithelial repair is necessary to restore normal lung structure and function. Regeneration of injured...