Research Interests: Ion Channel structure-function and regulation; Cellular and tissue electrophysiology of Heart Failure and Cardiac Resynchronization; Risk Prediction for Sudden Cardiac Death ...read more

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Locations

Johns Hopkins Outpatient Center
Appointment Phone: 443-997-0270

Background

Dr. Gordon Tomaselli is the chief of the Johns Hopkins Division of Cardiology and co-director of the Heart and Vascular Institute. He is an expert in the fields of sudden cardiac death and arrhythmias (abnormal heart rhythms). Specifically, Dr. Tomaselli focuses on ion channels, the movement of molecules in and out of heart cells, which generates the electrical impulses that cause the heart to beat. He holds several patents on methods to improve heart function and prevent arrhythmias, including an implantable device for the delivery of cell-derived biomolecules.

Dr. Tomaselli earned his undergraduate degree in biochemistry and chemistry in 1977 from the State University of New York at Buffalo and his medical degree in 1982 from Albert Einstein College of Medicine. He completed his medical training and residency at the University of California at San Francisco (UCSF) in 1985. He served as a research fellow at the UCSF Cardiovascular Research Institute and at the Johns Hopkins School of Medicine in before joining the faculty three years later. Since then, he has received numerous awards and served on a variety of boards and committees. Dr. Tomaselli was president of the Cardiac Electrophysiology Society from 2003 to 2005 and president of the American Heart Association from 2011 to 2012.

Dr. Tomaselli is an active researcher with more than 280 articles and book chapters.

Patents

The present invention relates to methods of customizing the biological activity (e.g. rhythmic firing rate) of cardiomyocytes derived from pluripotent or multipotent stem cells, followed by transplantation to modify cardiac functions in vivo (e.g. to augment or attenuate the heart rate by modifying the cellular excitability of recipient cells).

New methods and compositions are provided for preventing development of arrhythmias associated with ischemia and repurfusion. Preferred methods of the invention include treatment to inhibit the mitochondrial inner membrane anion channel.

A method of determining health and mortality includes obtaining a ventricular activation (RR) time series from a subject for multiple temporal intervals. The method also includes calculating a cardiac entropy in the RR time series over the temporal intervals using coefficient of sample entropy (COSEn). Additionally, the method includes comparing the cardiac entropy between the intervals to determine health and mortality. The absolute and relative changes in entropy over a patient's follow up period provide dynamic information regarding health and mortality risk. The determination of health and mortality can then be used to create a treatment plan for the subject.

System and method for risk stratification based on dynamic nonlinear analysis and comparison of cardiac repolarization with other physiological signals
Patent # WO2013170251 A2 | 05/11/2012

System and Method for Risk Stratification Based on Dynamic Nonlinear Analysis and Comparison of Cardiac Repolarization with Other Physiological Signals