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“If it is thought that my statements about the effect of this treatment are too definite, considering that I have only studied 11 cases, my comment would be that this would be quite right had a medicine given internally been studied, an injection or similar, where a systemic effect is expected. But here the treatment is purely local, spot by spot is treated and, for example, in one and the same patient one can observe the same effect ten times or more. In (assessing) systemic treatments, each patient can contribute only once (to an evaluation).”