Room Requests – Wolstein WRB1223A

Wolstein WRB1223A is a small conference room located on the ground floor of the Wolstein Research Building. A diagram of the room layout is located below. The room is equipped with these technological features:

Many clinical trials entail multiple endpoints, reflecting diverse aspects of treatment
effects, and yielding challenging research topics. Traditional approaches analyze
endpoints individually, leading to increased type I error or larger required sample sizes if
adjustment is made for multiple testing. In addition, small-to-mid-size trials are often
underpowered on clinical outcomes when the event rate is low. Multivariate hierarchical
global rank test, a nonparametric approach that incorporates same or different types of
endpoints into a hierarchical composite endpoint based on relative clinical importance and
tests research hypotheses using ranking strategies, has been proposed as a plausible
alternative adding to traditional approaches. Various global rank test approaches, with
nice applications in the clinical setting, have been published. However, there is still room
to improve the precision of global ranking test. In this research we will (1) compare the
performance of global rank tests, in a variety of aspects such as Type-I error, statistical
power, bias of test statistic estimates, and coverage probabilities of confidence intervals;
(2) develop a stratified global rank test strategy; (3) apply the global rank test methods to
the AQUARIUS trial data set; and (4) optionally, compare the power of the nonparametric
global rank test to a test based on parametric joint modeling.