exchange 2003 mailbox maintenance never ran should I run

I have an exchange 2003 mailbox store. On the limits tab of the store properties the box for "do not permanently delete mailboxes or item until the store has been backed up" is checked. My store is approximately 125 GB.

If I uncheck this box do you think it will cause any issues with the store running ok? It has not been unchecked in five years. I don't want to take off line if I don't have to. I backup the database with symantec backup exec and I am getting errors. I figured this would reduce my mailbox store size and help on backups. I don't want the maintenance process to cause any problems due to the fact that it probably has so much to do. I hate for my mail store to quit in the middle of the day. Thank you for any help you might give.

Thank you very much. I am looking more for a recommendation of the maintenance running after "not" running after five years and possibly freezing up the mailbox store. Has anyone ever unchecked this box and five years works of files and mailboxes been deleted during the maintenance process and had any trouble with the mailbox store freezing up. Thank you !!

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