......In the opposite direction, patients with obesity/diabetes who have high blood glucose and insulin display higher than normal levels of asprosin. Using this information, the researchers determined that they could develop an antibody against it, and use that antibody to neutralize asprosin, a process called immunologic sequestration. This way they could potentially reduce the amount of glucose released by the liver, resulting in the pancreatic cells needing to release less insulin.......

.....To test this concept, they treated diabetic mice with this antibody and found that even a single dose of the antibody worked well to reduce their insulin levels back toward the normal range. When such mice were treated for a longer period of time, their insulin resistance completely normalized.

I just wonders why after all good food.. and good habits ...still HDL level is not going up....

here we have few members who are with excellent HDL level.. one among them is shrisamarth ..and ShooterGeorge ....it will be wonderful to observe what they eat and what are habits followed by them....may be that will give us some clues...

Moderate use of alcohol has been linked with higher levels of HDL cholesterol. For healthy adults, that means up to one drink a day for women of all ages and men older than age 65, and up to two drinks a day for men age 65 and younger. Too much alcohol can cause weight gain, and may increase your blood pressure and triglyceride levels.

HMMM i think vinegar should help us.... let us ask MikePollard after one month or so....how much increase in his HDL level..after starting ACV.....

Accumulating evidence suggests that HDL or a specific apolipoprotein associated with HDL, such as apoA-I, is involved in the innate and adaptive immune responses primarily through the modulation of lipid raft components in monocytes/macrophages, dendritic cells, and T and B lymphocytes. Plasma HDL-C is usually reduced in chronic inflammation. These findings suggest that HDL protect against inflammation. However, chronic inflammation modifies HDL from a molecule with anti-inflammatory properties to one with proinflammatory properties, which leads to complex interpretation of plasma HDL-C levels. Although recent genetic and proteomic studies have unveiled important molecular players in HDL metabolism and immune activity, the mechanism for HDL regulation by these molecules remains unclear. Additional studies are required to answer several questions about HDL-C and inflammatory disease with regard to reduced plasma HDL-C levels as potential pathogenic cause of inflammatory diseases; HDL-C consumption and its consequences versus benefits for protection against these diseases; and altered HDL function in these diseases.

This study was supported in part by Grants-in-Aid from the Ministry of Education, Culture, Sports, Science, and Technology, Japan.

HDL levels are sometimes improved by drugs used to lower LDL and triglyceride levels — such as prescription niacin; fibrates such as gemfibrozil (Lopid); and certain statins, particularly simvastatin (Zocor) and rosuvastatin (Crestor).

But clinical trials for several drugs specifically designed to increase HDL levels were halted early, because they didn't reduce the risk of heart attacks.

For American populations in NHANES III, African-Americans averaged 53 mg/dl and white Americans averaged 49 mg/dl. This is a good comparison because Americans of different races eat similar diets.

In the Beijing Eye Study, Chinese were found to average 62.3 mg/dl, with one Beijing resident having an HDL over 270 mg/dl! [7] In the InterASIA study, however, Chinese averaged only 51.7 mg/dl. [8]

It’s difficult to infer much from this data, since diet and infectious burden affect HDL levels. The lower HDL in Kitava could be due to their higher carbohydrate intake. But overall, it is consistent with my evolutionary hypothesis. Kitavans have the lowest HDL levels, Americans of European descent are intermediate, and African-Americans and Chinese have the highest HDL levels.

cure Monounsaturated fats lower LDL and TGs, sat fats raise HDL and LDL; having 50:50 similar to body fat will improve TG:HDL ratio, as will limiting carbs of course, particularly fructose and high-glycaemic.

As for vitamin D, it is often not an issue of insufficiency. Ron Rosedale believes it is the hormonal messengers that are being misread, due to insulin resistance for example. Now, while even Caucasians may find the northern climate sparse in sunshine, the picture is much improved by having fats as above because they too can provide some vitamin D, enzymes to facilitate its function, plus enable storage since vitamin D is a fat soluble vitamin. The return of rickets in Wales for instance may not be due to children not receiving enough sunlight, but attributable to a natural fat deficient diet.