Infectious diseases are an increasing threat to shrimp farming industries worldwide and account for nearly $3 billion of annual economic loss. The need to devise novel approaches against these infectious agents is pressing, ...

Learning deficits in children following arsenic (As) exposure via drinking water have been epidemiologically described in the last decade. Arsenic is a persistent environmental toxin and exposure has been shown to perturb ...

The genus Flavivirus comprises viral species with positive sense, single stranded RNA genomes, most of which are transmitted by mosquitoes and ticks. During replication, RNA viruses have higher mutation rates than DNA ...

Children with Fetal Alcohol Spectrum Disorder exhibit long lasting behavioral impairments, such as learning disabilities, problems in executive functioning and memory deficits. Currently, there are no rationally designed, ...

Moderate prenatal alcohol exposure (PAE) in humans leads to learning and memory impairments later in life. The range of physical, behavioral, emotional, and social dysfunctions that are associated with PAE are collectively ...

Sleep apnea (SA) affects as many as 20% of the adult population in the United States. It elicits intermittent hypoxia (IH) and causes pulmonary hypertension (PH), however the mechanisms of this PH have not been well ...

The behavior of breast epithelial cells is influenced by their microenvironment, which includes stromal cells and extracellular matrix. During breast cancer progression, the tissue microenvironment fails to control ...

This work focuses on how arrestin regulates trafficking and signaling of the N-formyl peptide receptor (FPR), a G protein-coupled receptor (GPCR). GPCRs are involved in almost all physiologic processes and numerous ...

Spreading depression (SD) is a severe depolarization of both neurons and astrocytes that can propagate throughout CNS tissue. SD has long been associated with migraine, and recent work has strongly suggested that closely ...

Spreading depression (SD) is a wave of severe depolarization that spreads across brain tissue. For several decades, it has been suggested that (SD) may play a role in the expansion of brain injury following ischemic ...

Sin Nombre Virus (SNV) is a member of the hantavirus genus in the Bunyaviridae family. Hantaviruses contain a tripartite negative sense RNA genome with individual segments that form panhandle structures through intramolecular ...

The KH-type splicing regulatory protein (KSRP) promotes the decay of AU-rich element (ARE) containing mRNAs. Although KSRP is expressed in the developing and mature nervous system, very little is known about its role in ...

High blood pressure and endothelial dysfunction are two systemic abnormalities of the cardiovascular system that extensively contribute to the etiology of cardiovascular diseases, which represent the number one killer in ...

One of the components that obstruct the airway in asthma is the sudden and increased secretion of mucus from metaplastic mucous cells in small airways. Because previous studies have shown that the resolution of mucous ...

The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor involved in the metabolism of environmental pollutants including halogenated aromatic hydrocarbons, for example, 2,3,7,8-tetrachlorodibenzo-ρ-dioxin ...

The high affinity IgE receptor (FcεRI) plays a primary role in the pathogenesis of
allergic disease and shares significant similarities with the two other multichain immune
recognition receptor family members, the B-cell ...

Human papillomaviruses (HPVs) are the causative agent of cervical cancer and infect skin and mucosal membranes. Through wounding the virus establishes infection in the basal layer of human keratinocytes and requires ...

Stroke can be caused by focal ischemia due to cerebral artery occlusion or by global ischemia that occurs when global blood supply to the brain is interrupted. The acute phase of ischemic brain injury is followed by a ...

Metnase is a recently evolved human protein with methylase (SET) and nuclease domains that is widely expressed, especially in proliferating tissues. Metnase promotes plasmid and viral DNA integration, and through an ...