Reports of Practical Oncology and Radiotherapy

Reports of Practical Oncology and Radiotherapy

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If you believe that your paper was mistakenly rejected by other leading journals and you do not agree with final decision, the editors of Reports of Practical Oncology and Radiotherapy offer new fast track review. You may submit your manuscript to Reports of Practical Oncology and Radiotherapy together with all prior peer-reviews obtained from the other journal and your rebuttal letter. We guarantee review based decision within 72 hours from the time we will receive your manuscript.

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Summary:

Background Adenoid cystic carcinoma (ACC) is an uncommon form of malignant epithelial
neoplasm. It arises within major and minor salivary glands as well as mucous glands of the upper respiratory tract. It is characterized by high clinical malignancy, with unclear prognosis and unstable clinical course.
In histological examination of the tumour fi brillar structures are found in the extracellular matrix, containing fibronectin, type IV collagen and laminin.Aim The aim of the present study was to assess the protein components of the extracellular
matrix – laminin and fibronectin.Materials/Methods The study group included 30 patients with ACC of major salivary glands. The expression of immunohistochemical reaction for laminin and fi bronectin was assessed
using computerized analysis of obtained images.Results The analysis showed no signifi cant differences in mean laminin and fi bronectin
positive reaction areas. Analysis of the proteins depending on histological ACC subtype showed that fibronectin expression was signifi cantly lower in tubular cancer compared to other types. For laminin no significant expression difference was found.Conclusions In the future the immunochemistry of laminin and fi bronectin may become a
useful element of prognosis assessment in patients with adenoid cystic carcinoma.