bid

BID

A gene on chromosome 22q11.1, which encodes a member of the BCL-2 family of cell death regulators. BID heterodimerises with either agonist BAX or antagonist BCL2. Caspase-8 cleaves BID, mediating mitochondrial damage when the COOH-terminal part translocates to mitochondria, triggering cytochrome c release.

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