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After four seasons, “Nurse Jackie” creators-executive producers Linda Wallem and Liz Brixius are checking out of the Showtime dark comedy starring Edie Falco as a prescription-drug addicted New York nurse, Deadline reports.

The news comes after the critical hit premiered in early April to 653,000 total viewers, up 7 percent from the show’s third-season debut a year earlier.

Wallem and Brixius – out lesbians who were once a couple – cite traveling between their homes in Los Angeles to New York, where the show is filmed, as part of the reasoning behind moving on from the critically-acclaimed show, according to the article.

A TV veteran, Wallem was a writer on “Cybill,” executive producer on “That ’70s Show” and a co-executive producer on Lisa Kudrow’s short-lived “The Comeback.” Away from TV, Wallem is busy dating Melissa Etheridge and mom to four step-kids.

Though filming is complete, the series is only a third of the way into the fourth season. “Nurse Jackie”‘s ratings are holding up and Showtime is looking for a new showrunner, a good signal a fifth season might be on the horizon.

(Writer Linda Wallem, left, and writer Liz Brixius speak during the ‘America in Primetime’ panel during the PBS portion of the 2011 Summer TCA Tour held at the Beverly Hilton Hotel on July 30, 2011. Photo by Frederick M. Brown/Getty Images)

It has been reported that Wallem was the “best man” at Etheridge’s 2003 wedding to Tammy Lynn Michaels, who has said she knew Etheridge and Wallem were an item while Michaels was living with Etheridge.

Several patients of “Nurse Jackie” think Dr. Eleanor O’Hara, right, is one of the best doses of medicine on the Showtime drama, which was renewed last month by the network for a fourth season.

Venice magazine interviewed Eve Best, who plays the bisexual doctor, though she doesn’t discuss any storyline developments for O’Hara.

This season, however, O’Hara’s love life has been flatlined, and the show’s other female-loving females also have been absent or romantically sterile: Dr. Cooper’s two moms (Swoosie Kurtz and Judith Light, who replaced Blythe Danner), appeared only briefly to tell Coop they were divorcing.