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Mephedrone is often consumed with alcohol . A study in mice investigated the interrelation between these two substances, focusing on the psychostimulant and rewarding properties of mephedrone. It found that at low (non stimulant) doses alcohol significantly enhanced the psychostimulant effects of mephedrone. This effect was mediated by an increase in synaptic dopamine , as haloperidol , but not ketanserin , was able to block the potentiation by alcohol . Similarly, the rewarding properties of mephedrone were enhanced by a low non-rewarding dose of alcohol . [39]