OriGene Data

Full length human recombinant protein of human NKX2-1 ( NP_003308) produced in E.coli.

Clone Name

Clone UMAB162

Isotype

IgG1

Species Reactivity

Human

Concentration

0.5~1.0 mg/ml (Lot Dependent)

Guaranteed Application *

IHC

Suggested Dilutions

IHC 1:200,

Buffer

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Purification

Purified from cell culture supernatant by affinity chromatography

Reference Data

Target Name

Homo sapiens NK2 homeobox 1 (NKX2-1), transcript variant 2

Alternative Name

BCH; BHC; NK-2; NKX2.1; NKX2A; NMTC1; T/EBP; TEBP; TITF1; TTF-1; TTF1

Database Link

NP_003308

Function

This gene encodes a protein initially identified as a thyroid-specific transcription factor. The encoded protein binds to the thyroglobulin promoter and regulates the expression of thyroid-specific genes but has also been shown to regulate the expression of genes involved in morphogenesis. Mutations and deletions in this gene are associated with benign hereditary chorea, choreoathetosis, congenital hypothyroidism, and neonatal respiratory distress, and may be associated with thyroid cancer. Multiple transcript variants encoding different isoforms have been found for this gene. This gene shares the symbol/alias 'TTF1' with another gene, transcription termination factor 1, which plays a role in ribosomal gene transcription. [provided by RefSeq, Feb