EpiNet is the response arm of the network. It consists of multi-disciplinary national/territorial outbreak response teams. These teams were formed by Pacific Island health authorities in every Pacific Island country and territory in 2001 (see the list of National/Territorial EpiNet teams).

Besides coordinated surveillance and response field activities, the role of EpiNet is also to establish and maintain relevant PPHSN target-diseases surveillance and response protocols, including all technical and resource-related aspects of all operations.