“There’s a new era underway and I can tell because it’s been years since a white man was this nervous in Hollywood," he quipped.

For several minutes, Meyers tackled the subject with a wry sense of humor, taking care not to overstep the boundaries of taste.

“They tried to get a woman to host this show. They said, ‘Hey, how would you like to come and be judged by some of the most powerful people in Hollywood?’ And women were like, ‘Well, where is it?’ And they said it’s at a hotel, and long story short I’m your host tonight,” he said.

A couple of Meyers’ jokes came at the expense of Kevin Spacey, one of the several high-profile actors accused of sexual misconduct, but he reserved his most stinging barbs for Harvey Weinstein, the man whose alleged actions inspired the #MeToo movement.

“I think it’s time to address the elephant not in the room ... Harvey Weinstein isn’t here tonight because I’ve heard rumors he’s crazy and difficult to work with,” he said. “But don’t worry — he’ll be back in 20 years when he becomes the first person ever booed during the in memoriam.”

When the audience reacted with audible gasps, Meyers added, “It will sound like that.”