Inventor Flint Lockwood thought he saved the world when he destroyed his most infamous invention – a machine that turned water into food causing cheeseburger rain and spaghetti tornadoes. But Flint soon learns that his invention survived and is now combining food and animals to create "foodimals!" Flint and his friends embark on an adventurously mouth-watering mission to battle hungry tacodiles, shrimpanzees, hippotatomuses, cheesepiders and other foodimals to save the world – again!