Don't forget to :
- ask zindoz to hide the taskbar
- Set your form(s) with no border

Try to make your front-end selfcontained, not depending on a precise version of wmp ( real coders use bass.dll ), or a certain OS, or a certain version of the MDAC, or whatelse. If that's not possible, allow the user to deactivate the function

There are navigation programs that runs perfectly fine on a win98se 450Mhz K6-2
Remember that win98/Me are fully capable 32bits OSes too, and much more suited for small puters than vista), try to be retrocompatible.

From an ergonomic point of view, make sure a transistion between to screens takes less than 10ms, avoid any form of user confirmation for an action while driving, avoid error messages (create logs instead)