Redesigned for 2011, the Chrysler 300 undergoes further changes for 2012, including the reintroduction of the high-performance SRT8 that was temporarily discontinued last year (it returns with a 6.4-litre V8 instead of a 6.1-litre V8). An eight-speed automatic transmission is available on V6 models, and it includes a sport shift mode and paddle shifters on some models. There are new trim lines, and all-wheel drive is available on V6 models. The Beats by Dr. Dre audio technology is standard on the 300S model and available on the Limited and Luxury trim lines.

Three engines are available. The 300 uses a 3.6-litre V6; the 300C uses a 5.7-litre V8; and the SRT8 uses a 6.4-litre V8. The V6 uses a five-speed automatic transmission in the 300 Touring; it can be optioned to an eight-speed automatic that is standard on other 300 models. The V8 engines use a five-speed automatic. The 300 Limited, 300S and 300C can be optioned with all-wheel drive.