Synucleinopathies such as for example Parkinson’s disease multiple system atrophy and dementia with Lewy bodies are characterized by deposition of aggregated α-synuclein. addition of iron-induced α-synuclein oligomers resulted in quantized and stepwise increases in bilayer conductance indicating insertion of distinct transmembrane pores. These pores switched between open and closed states depending on clamped voltage revealing …Read More