In this work, five formulations of
L-alanyl-L-glutamine (glutamine dipeptide) containing pellets with different drug concentration were developed
and evaluated: F1 (9.07%); F2 (17.70%); F3 (27.98%); F4 (37.74%) e F5 (47.53%). Pellets were prepared by extrusion-
spheronization method and, further, dried in fluidized bad equipment. The following assays were carried
out with the batches obtained: granulometry, friability, true density and morphologic analysis. Between the five
formulations evaluated, pellets obtained from F3 present best yield (75.80%), most uniform particle size distribution
(89.67% of pellets with size in the range of 0.80 to 1.18), most high true density (2.1634 g/ml) and best aspect
(1.0795 ± 0.0410). Due to these features, pellets obtained from F3 were considered adequate to further polymeric
coating process in order to produce a multiparticulate system to prolong L-alanyl-L-glutamine release.