Effect of oral steroids on skin

In addition to the mentioned side effects several others have been
reported. In both males and females acne are frequently reported, as
well as hypertrophy of sebaceous glands, increased tallow excretion,
hair loss, and alopecia. There is some evidence that anabolic steroid
abuse may affect the immune system, leading to a decreased
effectiveness of the defense system. Steroid use decreases the
glucose tolerance, while there is an increase in insulin resistance.
These changes mimic Type II diabetes. These changes seem to be
reversible after abstention from the drugs.

As for individual use of a personal nature, outside therapeutic treatment, this is where we will find the vast majority of anabolic steroids. It is here we
will also find the biggest problems, not in terms of ill-effects of a physical or mental nature but of those surrounding legality. In places like the .
anabolic steroids are controlled substances, and here we will find the strictest of laws. This has created a new class of criminal; most commonly an adult
man with a family who is simply living an every day life like everyone else. These are issues that need to be discussed and you will find very few are
willing to touch them unlike .

Patients taking anticonvulsants such as phenobarbitone, phenytoin and carbamazepine together with their oral contraceptive steroid may suffer contraceptive failure because of the enzyme-inducing properties of these anticonvulsants. We have examined, in six women, the effect of sodium valproate, an effective broad spectrum anticonvulsant, on the area under the plasma concentration versus time profile (AUC) of ethinyloestradiol (EE2) and levonorgestrel (Ng). Prior to sodium valproate therapy the mean AUC for EE2 was 880 +/- 109 pg/ml X h (+/- .) and for levonorgestrel it was +/- ng/ml X h (n = 4). Between two and four months after sodium valproate therapy the mean AUC figures had not changed significantly, the figure for EE2 being 977 +/- 130 pg/ml X h and for levonorgestrel +/- ng/ml X h (p greater than or equal to in each case). We conclude that sodium valproate in the dose used (200 mg .) does not interact with oral contraceptive steroids.

The effect of chronic oral contraceptive (OC) usage on the disposition of theophylline was examined. Aminophylline solution (4 mg/kg) was given orally to 8 healthy female nonusers and to 8 healthy women who were chronic (6 months) OC users. The OC user group had a significantly lower total plasma clearance of theophylline than women not using OCs ( +or- vs. +or- ml/h/kg). The t1/2 was also significantly prolonged in the OC group ( +or- vs. +or- hours) while the volume of distribution was similar between the 2 groups. The serum ethinyl estradiol (EE) concentrations after oral OC administration were measured simultaneously. The apparent clearance of EE was about 30% lower in the OC users. A significant positive correlation was found between the apparent EE clearance and the plasma clearance of theophylline. The effects of OCs are predominantly due to chronic use with decreased elimination of both theophylline and EE.

Effect of oral steroids on skin

The effect of chronic oral contraceptive (OC) usage on the disposition of theophylline was examined. Aminophylline solution (4 mg/kg) was given orally to 8 healthy female nonusers and to 8 healthy women who were chronic (6 months) OC users. The OC user group had a significantly lower total plasma clearance of theophylline than women not using OCs ( +or- vs. +or- ml/h/kg). The t1/2 was also significantly prolonged in the OC group ( +or- vs. +or- hours) while the volume of distribution was similar between the 2 groups. The serum ethinyl estradiol (EE) concentrations after oral OC administration were measured simultaneously. The apparent clearance of EE was about 30% lower in the OC users. A significant positive correlation was found between the apparent EE clearance and the plasma clearance of theophylline. The effects of OCs are predominantly due to chronic use with decreased elimination of both theophylline and EE.