The Eagles lost key defender Tom Barrass to a three-month foot setback before the round five loss to Port Adelaide, with coach Adam Simpson declaring they would have to stop holding sessions at Optus following a worrying trend of lower-leg issues.

Now Lobb is out for an extended period after reporting foot soreness following the uplifting away win over Collingwood in round 11.

Scans confirmed the 206cm giant has a fractured metatarsal and Lobb could join star full-back Alex Pearce (fractured ankle) and spearhead Matt Taberner (foot) on the sidelines for the rest of 2019.

"Given the recent lower leg and foot injuries to key talls, an assessment of training and medical assessment protocols will be conducted to ensure we are operating at best practice," football boss Peter Bell said.

Without Pearce and Lobb, Freo will have to call on their big man depth, with young ruckman Sean Darcy and forgotten defender Griffin Logue in line to return.

Darcy hasn't played since sustaining an ankle injury while playing for Peel four weeks ago, and is the next in line with veteran Aaron Sandilands (calf) sidelined indefinitely.

Scott Jones and Lloyd Meek are also available if Darcy isn't ready.

Logue's excellent pre-season was ruined by hamstring issues, but the 21-year-old is likely to come in for Pearce and play his first game since round 22, 2017 after last season was wiped out by foot problems.