Fusion

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Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:query proteins and first shell of interactors

white nodes:second shell of interactors

Node Content

empty nodes:proteins of unknown 3D structure

filled nodes:some 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

PP1S114_86V6.1

Predicted protein (741 aa)

Predicted Functional Partners:

PP1S58_120V6.1

Predicted protein (122 aa)

0.999

PP1S144_14V6.1

Predicted protein (735 aa)

0.999

PP1S56_227V6.2

Predicted protein (296 aa)

0.999

PP1S78_28V6.2

Predicted protein (288 aa)

0.995

PP1S142_26V6.1

Predicted protein (491 aa)

0.994

CTU1

Cytoplasmic tRNA 2-thiolation protein 1; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position (348 aa)

0.991

PP1S302_56V6.1

annotation not available (1177 aa)

0.991

PP1S34_86V6.1

Cytoplasmic tRNA 2-thiolation protein 2; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6/CTU1 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position (492 aa)

0.976

PP1S183_117V6.1

Predicted protein (383 aa)

0.974

PP1S99_92V6.1

Ubiquitin-related modifier 1 homolog; Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2- thiolation reaction by being thiocarboxylated (-COSH) at its C- terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins. The thiocarboxylated form serves as substrate for conjugation and oxidative stress sp [...] (99 aa)

a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1

node2

node1 accession

node2 accession

node1 annotation

node2 annotation

score

CTU1

PP1S114_86V6.1

PP1S54_267V6.1

PP1S114_86V6.1

Cytoplasmic tRNA 2-thiolation protein 1; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position

Predicted protein

0.991

CTU1

PP1S302_56V6.1

PP1S54_267V6.1

PP1S302_56V6.1

Cytoplasmic tRNA 2-thiolation protein 1; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position

annotation not available

0.557

CTU1

PP1S34_86V6.1

PP1S54_267V6.1

PP1S34_86V6.1

Cytoplasmic tRNA 2-thiolation protein 1; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position

Cytoplasmic tRNA 2-thiolation protein 2; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6/CTU1 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position

0.999

CTU1

PP1S58_120V6.1

PP1S54_267V6.1

PP1S58_120V6.1

Cytoplasmic tRNA 2-thiolation protein 1; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position

Predicted protein

0.788

CTU1

PP1S99_92V6.1

PP1S54_267V6.1

PP1S99_92V6.1

Cytoplasmic tRNA 2-thiolation protein 1; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position

Ubiquitin-related modifier 1 homolog; Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2- thiolation reaction by being thiocarboxylated (-COSH) at its C- terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins. The thiocarboxylated form serves as substrate for conjugation and oxidative stress sp [...]

0.905

PP1S114_86V6.1

CTU1

PP1S114_86V6.1

PP1S54_267V6.1

Predicted protein

Cytoplasmic tRNA 2-thiolation protein 1; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position

0.991

PP1S114_86V6.1

PP1S142_26V6.1

PP1S114_86V6.1

PP1S142_26V6.1

Predicted protein

Predicted protein

0.994

PP1S114_86V6.1

PP1S144_14V6.1

PP1S114_86V6.1

PP1S144_14V6.1

Predicted protein

Predicted protein

0.999

PP1S114_86V6.1

PP1S183_117V6.1

PP1S114_86V6.1

PP1S183_117V6.1

Predicted protein

Predicted protein

0.974

PP1S114_86V6.1

PP1S302_56V6.1

PP1S114_86V6.1

PP1S302_56V6.1

Predicted protein

annotation not available

0.991

PP1S114_86V6.1

PP1S34_86V6.1

PP1S114_86V6.1

PP1S34_86V6.1

Predicted protein

Cytoplasmic tRNA 2-thiolation protein 2; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6/CTU1 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position

0.976

PP1S114_86V6.1

PP1S56_227V6.2

PP1S114_86V6.1

PP1S56_227V6.2

Predicted protein

Predicted protein

0.999

PP1S114_86V6.1

PP1S58_120V6.1

PP1S114_86V6.1

PP1S58_120V6.1

Predicted protein

Predicted protein

0.999

PP1S114_86V6.1

PP1S78_28V6.2

PP1S114_86V6.1

PP1S78_28V6.2

Predicted protein

Predicted protein

0.995

PP1S114_86V6.1

PP1S99_92V6.1

PP1S114_86V6.1

PP1S99_92V6.1

Predicted protein

Ubiquitin-related modifier 1 homolog; Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2- thiolation reaction by being thiocarboxylated (-COSH) at its C- terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins. The thiocarboxylated form serves as substrate for conjugation and oxidative stress sp [...]

0.956

PP1S142_26V6.1

PP1S114_86V6.1

PP1S142_26V6.1

PP1S114_86V6.1

Predicted protein

Predicted protein

0.994

PP1S142_26V6.1

PP1S144_14V6.1

PP1S142_26V6.1

PP1S144_14V6.1

Predicted protein

Predicted protein

0.536

PP1S142_26V6.1

PP1S302_56V6.1

PP1S142_26V6.1

PP1S302_56V6.1

Predicted protein

annotation not available

0.934

PP1S142_26V6.1

PP1S56_227V6.2

PP1S142_26V6.1

PP1S56_227V6.2

Predicted protein

Predicted protein

0.892

PP1S142_26V6.1

PP1S58_120V6.1

PP1S142_26V6.1

PP1S58_120V6.1

Predicted protein

Predicted protein

0.982

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Functional enrichments in your networkNote: some enrichments may be expected here (why?)

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Statistical background

For the above enrichment analysis, the following statistical background is assumed: