Nucleic Acids 2016

ConferenceSeries Ltd invites all the participants from all over the world to attend the “Global Congress on Nucleic Acids: Biology, Health and Diseases” on August 04-05, 2016 New Orleans, USA which includes prompt keynote presentations, Oral talks, Poster presentations and Exhibitions.

Nucleic acids, which include DNA (deoxyribonucleic acid) and RNA (ribonucleic acid), are made from monomers known as nucleotides. Each nucleotide has three components: a 5-carbon sugar, a phosphate group, and a nitrogenous base. If the sugar is deoxyribose, the polymer is DNA. If the sugar is ribose, the polymer is RNA. Different phenomenon occurs like DNA replication and genome integrity is maintained. Change in cell function occurs due to DNA structure and dynamics. Sometime DNA damage occurs while different process of replication and transcriptions which can be studied through DNA Repair which provide insight from molecular mechanism to novel cancer treatments. Various structures of DNA exist among which the unique one is the Quadruplex structures which is the rarest of them all. Today, with all the latest innovation in the field of genetic engineering we can know more Application in DNA technology.

There are various enzyme used for DNA replication, transcription and translation. For replication DNA and RNA polymerases are used. To stop the chain reaction DNA and RNA methyl transferases are used. Ribozymes (ribonucleic acid enzymes), also termed catalytic RNA, are RNA molecules that are capable of catalysing specific biochemical reactions, similar to the action of protein enzymes. Various researches are made to study the Scope of Ribozyme Catalytic Activities. While transcription, enzyme uses to ligate the nicks are RNA ligases.

Nucleic acids Therapeutics encompass a vast array of approaches with a set of key considerations based on their size and mechanism of action like aptamers, antisense, small interfering RNA (siRNA), exon skipping, RNA editing. Medicinal promise of pre transcription & post- transcriptional gene silencing (PPTGS) using oligodeoxynucleotides, small interfering RNA, microRNA and other nucleic acid based molecules can be developed into effective drugs for the treatment of many common diseases that are generally responsible for a great deal of human suffering. Numerous types of cancer are known to have abnormal genes that are useful in disease states. These genes are attractive targets to approach for treatment of wide range of cancers. In different experimental systems nucleic-acid-based molecules have been shown to be very effective tools for adjusting gene expression in a sequence specific manner. Thereby they appear to be one of the most promising cancer therapeutics. They are more specialized and low toxic than conventional chemotherapy.

Chemical biology is a scientific discipline spanning the fields of chemistry, biology, and physics. It involves the application of chemical techniques, tools, and analyses, and often compounds produced through synthetic chemistry, to the study and manipulation of biological systems. Together with proteins, nucleic acids are the most important biological macromolecules; each are found in abundance in all living things, where they function in encoding, transmitting and expressing genetic information. In other words, information is conveyed through the nucleic acid sequence, or the order of nucleotides within a DNA or RNA molecule. There are Novel methods of delivery of nucleic acids. Strings of nucleotides strung together in a specific sequence are the mechanism for storing and transmitting hereditary or genetic information via protein synthesis. With the help of Cellular and in vivo targeting applications of nucleic acids we can get the insight of the molecules. Techniques for Novel synthesis or modifications of nucleic acids are being developed through which we can selection nucleic acids for its function. With the latest inventions, Nanotechnology and nanomaterial development using nucleic acid, are in great practice.

RNA molecules inhibit gene expression, typically by causing the destruction of specific mRNA molecules. Two types of small ribonucleic acid (RNA) molecules – microRNA (miRNA) and small interfering RNA (siRNA) – are central to RNA interference. RNAs are the direct products of genes, and these small RNAs can bind to other specific messenger RNA (mRNA) molecules and either increase or decrease their activity, for example by preventing an mRNA from producing a protein. RNA interference has an important role in defending cells against parasitic nucleotide sequencing – viruses and transposons.

One of these active processes is protein synthesis, a universal function whereby mRNA molecules direct the assembly of proteins on ribosomes. To discuss the problems like How RNA molecules behave and misbehave, this process uses transfer RNA (tRNA) molecules to deliver amino acids to the ribosome, where ribosomal RNA (rRNA) links amino acids together to form proteins. Making and using RNA in the nucleus is the process which initiates translation. Fate of RNA in the cytoplasm and further process like translation and degradation are some of the major steps in protein expression. Different variants of RNA like Non Coding mRNA are also produced.

Sequencing is the process of determining the order of nucleotide bases (A,C,T and G) within the stretch of DNA. The sequence of DNA encodes the necessary information for living things to survive and reproduce. Determining the sequence is therefore useful in fundamental research into why and how organisms live, as well as in applied subjects. Because of the key importance DNA has to living things, knowledge of DNA sequencing are useful in practically any area of biological research. For example, in medicine it can be used to identify, diagnose, and potentially develop treatments for genetic diseases. Similarly, research intopathogens may lead to treatments for contagious diseases. Biotechnology is a burgeoning discipline, with the potential for many useful products and services.

Signal transduction occurs when an extracellular signalling molecule activates Protein phosphorylation networks located on the cell surface or inside the cell. In turn, this receptor triggers a biochemical chain of events like G-proteins in cellular regulation inside the cell, creating a response. Depending on the cell, the response alters the cell's metabolism and Mechanisms of signalling specificity in cell fate, shape, gene expression, or ability to divide. The signal can be amplified at any step. Thus, one signalling molecule can cause many responses like control of dna replication initiation and genomic stability.

Regulation of gene expression includes a wide range of mechanisms that are used by cells to increase or decrease the production of specific gene products (protein or RNA), and is informally termed gene regulation. Sophisticated programs of gene expression are widely observed in biology, for example to trigger developmental pathways, respond to environmental stimuli, or adapt to new food sources. Virtually any step of gene expression can be modulated, from transcriptional initiation, to RNA processing, and to the post-translational modification of a protein.

Gene regulation is essential for viruses, prokaryotes and eukaryotes as it increases the versatility and adaptability of an organism by allowing the cell to express protein when needed. Histone, DNA modifying enzymes and chromatin remodelling factors are major area to concentrate.

Protein modifications by formaldehyde treatment and histological processing have frustrated attempts to use FFPE tissues for proteomic analyses due to the difficulty in extracting representative proteins. Ubiquitin and Ubiquitin-like modifications are some of the examples. This limitation has restricted studies of diseases that evolve slowly or for those where the time between treatment and recurrence is long, such as prostate cancer and breast cancer. The Multivescular body and endocytosis are being studied for investigating these diseases. Coupling the medical history and pathology information from FFPE tissues with proteomic investigations would produce a wealth of practical information on important human diseases and will also unveil the Mechanisms of bacterial pathogenesis. Major change in the structure can be caused by Regulatory thiol modifications.

DNA repair is a collection of processes by which a cell identifies and corrects damage to the DNA molecules that encode its genome. In human cells, both normal metabolic activities and environmental factors such as UV light and radiation can cause DNA damage, resulting in as many as 1 million individual molecular lesions per cell per day. Many of these lesions cause structural damage to the DNA molecule and can alter or eliminate the cell's ability to transcribe the gene that the affected DNA encodes. Other lesions induce potentially harmful mutations in the cell's genome, which affect the survival of its daughter cells after it undergoes mitosis. As a consequence, the DNA repair process is constantly active as it responds to damage in the DNA structure. When normal repair processes fail, and when cellular apoptosis does not occur, irreparable DNA damage may occur, including double-strand breaks and DNA cross linkages .The rate of DNA repair is dependent on many factors, including the cell type, the age of the cell, and the extracellular environment. A cell that has accumulated a large amount of DNA damage, or one that no longer effectively repairs damage incurred to its DNA, can enter one of three possible states.

ConferenceSeries Ltd is pleased to invite the contributors across the globe on its "Global Congress on Nucleic Acids: Biology, Health and Diseases" which is slated at New Orleans, USA. during Aug 04-05, 2016.

International Conference on Nucleic Acids: Biology, Human health and Diseases (Nucleic Acid-2016) provides a premier platform to present and discuss fundamental discoveries in nucleic acids biology, which have impacted nearly every facet of biology with wide ranging implications for human health. The overarching long-term goal of this conference is to create a scientific environment conducive to cross-disciplinary discussion and exchange of new ideas by bringing together the world’s leading researchers with junior scientists, to enhance our understanding of the role of nucleic acids in biology, human health and disease. Specific topics will include: Chemical Biology and Nucleic Acid Chemistry, DNA Replication and Genome Integrity; RNA/DNA Structure and Dynamics; Chromatin and Transcription; RNA/DNA in Cellular Defense; Computational Biology; RNA/DNA Conflicts; Non-Coding RNAs; and Mechanisms of Signal Transduction. The Nucleic Acids Conference is unique in bringing the RNA and DNA fields together.

Our Conference will provide a perfect platform addressing:

· Laudable talks by the top-notch of the global scientific community

· Sterling workshop sessions

· Remarkable Awards and Global Recognition to meritorious Researchers

· Global Networking with 50+ Countries

· Novel Techniques to Benefit Your Research

· Global Business and Networking Opportunities

· Exquisite Platform for showcasing your products and International Sponsorship

ConferenceSeries Ltd is glad to invite you to the “ Global Congress on Nucleic Acids: Biology,Health and Diseases” to be held during August 04-05, 2016 at New Orleans, USA. The conference emphasizes the theme “Recent advances in applications of Nucleic acid” focusing on the latest ideas and advances for nucleic acid isolation and purification. The conference Nucleic Acids 2016 welcomes the innovative strategies in the area of nucleic acid research and also proposes a unique opportunity for the explorers from all over the world to gather, share and perceive new scientific interactions upon the various perceptions of Nucleic Acid.

ConferenceSeries Ltd organizes 300+ Conferences Every Year across USA, Europe & Asia with support from 1000 more scientific societies and Publishes 400+ Open access journals which contains over 30000 eminent personalities, reputed scientists as editorial board members.

Nucleic acid isolation and purification is often the first step in most molecular biology techniques like cloning, sequencing, polymerase chain reaction (PCR), and others. These techniques find applications in fields like life science research, genetic engineering, molecular diagnostics, and forensics.The DNA is the biological molecule that stores all the genetic information of the cell. Everything that the cells has to do, at what time in its life cycle, and how it has to do it is determined by the information contained in the DNA molecule. In addition, DNA functions as the molecule that carries on the genetic information from parent to offspring.

RNA is made when the complex biochemical decodification machinery of the cell acts on the DNA to extract the information needed for a particular function. RNA is a key factor for protein synthesis. RNA is responsible for transferring the information contained in the DNA to make a particular protein needed in a specific process for a specific function. Nucleic Acids 2016 is an international platform for presenting research about Nucleic Acid and related concepts, sharing alternative ideas about the mechanism and functions of DNA & RNA, thus contributing to the dissemination of information about the biological molecule that stores all the genetic information of the cell.

Why New Orleans?

New Orleans is a major United States port and the largest city and metropolitan area in the state of Louisiana and is located in the southeast part of the state, between the Mississippi River and Lake Ponchartrain. Its name comes from Orleans, a city on the Loire River in France. Known for its French Creole architecture and multilingual and cultural heritage, New Orleans is often called the most unique city in the United States. The population of the city was 378,715 as of the 2013 U.S. Census Bureau. In 2012, 24/7 Wall St. identified the 10 largest cities with the fastest growing populations in the US based on Census Bureau data. New Orleans ranked #1, with 4.9% growth from 2010 to 2011.

New Orleans has one of the world's greatest international ports and it is a major focus of the city's economy. New Orleans is home to the corporate offices of oil companies with major offshore operations in the Gulf of Mexico, as well as the distribution and service centres of offshore equipment suppliers and fabricators. The manufacturing industry is a significant part of the economy, with petroleum, petrochemical, shipbuilding, and aerospace industries all playing a role. The New Orleans region also functions as a mining, processing, and transportation centre for other minerals, principally sulphur. Service industries are playing a larger role, with health care and telecommunications leading the way. The New Orleans region is widely regarded as a leading centre of medicine and health care in the South.

Committed to learn about nucleic acid isolation and purification. This is the best opportunity to outreach the largest gathering of participants from around the world. Conduct presentations, distribute and update knowledge about the current situation of nucleic acid research and receive name recognition at this 2-day event. World-eminent speakers, most recent researches, latest purification techniques and the advanced updates in nucleic acid isolation and purification technique are the principal features of this conference.

Nucleic Acids Associations and Societies

· International society of Nucleosides ,Nucleotides, Nucleic Acids

· Royal society of Chemistry

· Biochemical society

· Federation of European Biochemical societies

· The Moroccan society of Biochemistry and Molecular Biology

· The Oligonucleotide Therapeutic society

· American Chemical Society

· Chemical society of Japan

· The American Society of Gene & Cell Therapy

Universities involved in Nucleic Acids research across the world:

· University of Southampton, UK

· Cambridge University, UK

· Cranfeild University, UK

· De Montfort University, UK

· University of Alberta, Canada

· University of British Columbia, Canada

· University of Hamburg, Germany

· Max Planck Institute for molecular Genetics, Germany

Universities in USA involved in Nucleic Acids Research:

· University of colorado, USA

· Stanford University, USA

· Boston University, USA

· University of California, USA

· Purdue University, USA

· Rutgers University, USA

· Rockefeller University, USA

· Massachusetts Institute of Technology, USA.

Universities in New Orleans involved in Nucleic Acids Research:

· The University of New Orleans, USA

· Tulane University,New Orleans, USA

· Louisiana State University,New Orleans, USA

· Alton Oschner Medical Foundation,New Orleans, USA

Market Analysis

The global market is expected to grow at a CAGR of close to 8.11% between 2013 and 2018, to reach $3,106.28 million by 2018. The global market is dominated by North America, followed by Europe, Asia, and the Rest of the World . North America accounted for a 38.3% share of this market in 2013.

The global isothermal nucleic acid technology (INAAT) market is estimated to reach $1,651 million by 2018 at a CAGR of 13.5% during the forecast period. The market growth is primarily attributed to increasing demand for advanced isothermal based molecular testing over conventional thermal polymerase chain reaction (PCR) technology.

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