Experiments on animals demonstrated that a 3,6 and 9 month long administration of haloperidol evokes in the somatosensor zone of the cortex and subcortical nodes of rats some morphofunctional changes of the cytoplasma, nucleus, nucleoli, neurons and glial cells which are interpreted as functional-adaptive, dystrophical and compensatory. A use of haloperidol… (More)

Experiments on white mice demonstrated that the appearance of extrapyramidal disturbances depends upon the scheme of haloperidol administration. A long-term use of the preparation leads to development of habituation, while its cessation--to symptoms similar to withdrawal. The development of extrapyramidal disturbances does not increase the antagonism of… (More)