Lipitor, the world's top-selling drug until U.S. generic competition hit two years ago, now faces cheaper copycats in Europe and Australia, too. Those smaller revenues were shifted to the established products unit, where sales edged up 2 percent to $2.42 billion.

But Pfizer's new clot-preventing drug Eliquis, a potential blockbuster that's lagged behind two competitors, brought in only $71 million in the quarter. Pfizer shares that with partner Bristol-Myers Squibb Co.

Pfizer forecast 2014 adjusted profit of $2.20 to $2.30 per share and revenue of about $50.2 billion, despite expecting another $3 billion in revenue losses due to generic competition.

"We start 2014 with a sound strategy and a strong business," CEO Ian Read told analysts on a conference call.

He noted Pfizer will report midstage test results this year for palbociclib for advanced breast cancer, plus some other drugs and vaccines. Analysts are closely watching heavily touted palbociclib, which also is being tested against melanoma, lung and other cancer types.