Zhang and colleagues (1) reported that C-reactive protein levels were not significantly associated with increased risk for colorectal cancer in women. However, they did not consider diabetic status in the studied population. A growing body of evidence indicates that type 2 diabetes mellitus is associated with increased risk for colorectal cancer (2-4). Furthermore, elevated glycated hemoglobin concentrations, even at levels below those used for diagnosis of diabetes, have been shown to be associated with increased colorectal cancer risk (5). Thus, abnormal glucose metabolism might have been a confounder in this study (1).