For multipathing to work properly, each LUN must present the same LUN ID number to all ESXi hosts.

Make sure the storage device driver specifies a large enough queue. You can set the queue depth for the physical HBA during system setup. For information on changing queue depth for HBAs and virtual machines, see the vSphere Troubleshooting documentation.

On virtual machines running Microsoft Windows, increase the value of the SCSI TimeoutValue parameter to 60. This increase allows Windows to better tolerate delayed I/O resulting from path failover. For information, see Set Timeout on Windows Guest OS.