When a legendary jazz musician collapses mid-session, House and his team run into technical difficulties treating the man, who has amyotrophic lateral sclerosis but when he orders to have a DNR, House disobeys it and ends up in court.

After much convincing (drugging Mark's drink), Stacy's husband Mark is admitted to the hospital to undergo a battery of tests which come up negative even though his steadily growing symptoms indicate he is dying.

A famous cyclist is brought to House's clinic after collapsing during a race. He is surprisingly honest about several illegal medications and techniques he applied to himself, but his sickness is not caused by any of these.

A famed journalist collapses in his magazine company's office. While he acts nonchalantly after getting up, it soon becomes clear from his word salad inflected speech that he is suffering from aphasia.

House tries to treat a man who has a seizure but doesn't realize it and needs a new heart. When the transplant committee votes "no" for a new heart, House tries to get one from a dead woman whose organs were also rejected by the committee.

During a charity Casino Night, Cuddy gets a patient whom she dismisses as being dehydrated; however, House realizes that the patient is exhibiting the same symptoms as a woman who died under House's watch twelve years ago.

House is trying to cure a crooked cop who acts turbulent and laughs uncontrollably, but he and his team are unable to determine the cause. When Foreman starts showing similar symptoms, the situation gets far worse than anybody expected.

House is cut off from his supply of Vicodin completely by Cuddy, and is eventually removed from his team's case: a 15-year-old girl brought in to the hospital for treatment, suffering from a collapsed lung and anemia.

A brain-damaged music savant (Special Guest Star Dave Matthews) has seizures despite being on anti-seizure medications, while everyone is shocked to learn that House has entered himself for brain cancer treatment.

A 6-year-old girl suffers ailments expected in patients much older. Tensions between Chase and Cameron lead House to intentionally assign them to the same tasks, including investigating the young girl's home.

A 14-year-old leukemia patient's only hope of survival is a bone marrow transplant from his younger brother. But when he gets sick, the team must race against time to save both kids. Meanwhile, Foreman must deal with the consequences of the previous patient's death.

Speculation over Foreman's resignation continues, while a young girl named Addie is admitted after bleeding from the mouth during martial arts practice. House and Wilson are secretly concerned about each other.

House meets his match in the form of Nathan Harrison (guest star Nick Lane), an obnoxious 16-year-old chess prodigy with intense head pain and behavioral issues, who manages to annoy and offend every member of House's team during his course of treatment. Meanwhile, Foreman's frustration with House reaches a new level when he believes House sabotages his job interview with another hospital.

House and the team take on the case of a young woman who, along with her husband, is rescued at sea en route from Cuba in a desperate attempt to see House and get a diagnosis for her illness. During her stay in the hospital, she develops a new symptom: her heart stops - but she keeps talking... Meanwhile, Foreman prepares for his last day at Princeton Plainsboro Teaching Hospital.

When an office building collapses, House has to work fast to diagnose a young woman, Megan, who survived the disaster. Due to her injuries, Megan's only form of communication is blinking. House, without a team since Foreman and Cameron quit and he fired Chase, talks through his ideas with a janitor at the hospital. As House persists in diagnosing Megan by himself, he realizes that the case is not what it appears, and that solitude may not be the answer.

House is approached by a fighter pilot named Greta, a candidate for NASA’s astronaut training program. Greta suffers from a neurological disorder in which she is converting visual images to sound, or hearing with her eyes. Knowing that NASA would reject any possibility of her becoming an astronaut if they knew of her problem, Greta begs House to treat her in secret. Meanwhile, House is ruffled when he thinks he sees Cameron, Chase and Foreman in the hospital hallways.

The final 10 fellowship candidates compete ferociously when House splits them into two teams by gender. They are assigned to diagnose and treat a wheelchair-bound man with Spinal Muscular Atrophy who is slowly suffocating. As the two teams are trying to one-up each other, complications arise when one team treats the patient but doesn’t follow through to make sure their treatment was executed. While the students are busy with their assignment, House experiments on himself to see what happens in the moments when people hover between life and death. Meanwhile, Foreman runs his own team of fellows in his new job at another hospital, and resorts to using a very “House-like” treatment to help a patient.

While having a seizure, a funeral-home cosmetician (Azura Skye) hallucinates that she's being violently raped by one of the corpses she's working on. Later in the hospital, she acts as though her dead mother is in the room with her. Meanwhile, Cameron offers advice to one of the seven candidates for House's team; Foreman has lunch with Cuddy.

फोरमैन अस्तपताल वापस आ जाता है और उसे हाउस की टीम के लोगों को देखने का काम दिया जाता है। A man is mugged and suffers from a respiratory arrest. He has no memories of who he is, but instead reads the personality of the most dominant person in the room, applying it to himself to create a temporary identity. His accuracy of being a judge of character intrigues House, who manipulates the man to judge others and ultimately judges whether House is more dominant than Cuddy.

House is recruited by the CIA to help diagnose a deathly ill agent with an unknown illness. The agent's medical case is being spearheaded by Dr. Samira Terzi (guest star Michael Michele), who offers up very little information about the agent's history or previous assignments. With limited information to go on, House uses some unorthodox methods to try to crack the code and determine a diagnosis in time to save his mystery patient's life. Meanwhile, Foreman faces resistance from the remaining six fellowship candidates when they question his judgment and argue over the diagnosis of a female drag car racer who passed out after a race.

House and his team are followed by a documentary film crew as they treat a teenager with a major facial deformity who suffered a heart attack prior to a reconstructive procedure. As they work to diagnose the teen, House finds himself distracted by several of the candidates vying for a spot on his team, causing him to question his own motives for having chosen them.

House encounters a magician whose heart failed while performing an underwater escape act. While the remaining fellowship candidates work to diagnose the illusionist, House is determined to prove that he's a scam artist faking his ailments to cover up the fact that he nearly drowned during his act.

House assigns the candidates to a particularly challenging case involving an uncooperative, over-the-hill former rock star with a history of drug abuse and civil disobedience while Cuddy orders House to make a final decision and hire the members of his team.

House and the team treat a woman who suffers from a sudden paralysis of the hands that causes an injury to her daughter while she's spotting her at an indoor rock-climbing wall. As House probes the woman and her injured daughter for any leads as to what might be causing her condition, he is convinced that the woman is withholding information.

When Dr. Cate Milton (guest star Mira Sorvino), a psychiatrist trapped at the South Pole and the research station's only doctor, becomes ill in the middle of her assignment, she and Dr. House are thrust into a long-distance relationship of sorts. Unable to get Cate out or any additional medical supplies to the South Pole station, House and his team must resort to treating her via webcam.

House and the team encounter a woman (guest star Laura Silverman) admitted to Princeton-Plainsboro after she collapsed at her wedding. Her test results come up negative for a variety of common diseases, which leads the team to suspect foul play. When they discover the woman had been a music producer living in the fast lane until she began to practice Hasidic Judaism, House insists that people do not change, and that her seemingly rash decision may be a symptom of the underlying condition.

House suspects an emergency room patient has a bigger problem than the E.R. initially diagnosed based on the fact that the patient is too nice. A skeptical House questions the patient's sunny disposition as the team tries to get to the bottom of his illness, but disagrees with House that niceness is a symptom. Meanwhile, House and Amber are at odds about how much time they each get to spend with Wilson, and Cuddy demands House give his team performance reviews.

House is convinced one of the actors on his favorite soap opera (guest star Jason Lewis) “Prescription Passion” has a serious medical condition after observing his symptoms on television. House decides to intervene and take matters into his own hands, but both the actor and House's own team dismiss House’s assessment and do not believe there is anything wrong with him. Meanwhile, Amber and Wilson have their first argument, and Cuddy tries to keep up appearances when an inspector makes an unexpected visit to Princeton-Plainsboro.

House finds himself dazed, confused and covered in blood after surviving a bus accident that left dozens seriously injured. Unable to clearly recall the events leading up to the crash due to his head injuries, House becomes convinced through his flashbacks that a fellow bus passenger was exhibiting signs of a deadly illness prior to the crash. Much to the team's dismay, House pushes through the pain of his own injuries, desperate to piece together the fragments of his shattered memory in order to save someone who might not even know he or she could be dying.

Clues inside House's head hold the key to a patient's condition, and House's friendship with Wilson is tested beyond limits as murky memories from the bus accident the night before threaten to change their lives forever.

House's fifth season began airing on September 16, 2008. It began to air in a new timeslot from September–December: Tuesday 8/7c.[11] Starting in January 2009, House will be moved to Wednesdays at 8/7c.[12]

In the aftermath of personal tragedy, Wilson resigns from the hospital, and ends his friendship with House. Cuddy desperately tries to get the two to repair their friendship. Meanwhile, Thirteen struggles with her medical problems while helping treat an executive assistant with a similar personality to her own.

An organ donor's organs are responsible for the deaths of several patients, and the team work to save the last two recipients. Meanwhile, House hires private detective Lucas (Michael Weston) to spy on Wilson, as well as his team during the differentials.