We suggest that the COMT*H/*H genotype is a marker of increased risk for schizophrenia (OR=2.56, 95%CI 1.60-4.12), both out-directed (OR=1.84, 95%CI 1.08-3.16) and in-directed aggressive behavior (OR=2.28, 95%CI 1.39-3.77). So, catecholaminergic alterations may contribute to these behaviors independently from such psychiatric disorder as schizophrenia.