Research Labs

Ophthalmic Research

Cleveland Clinic Cole Eye Institute Department of Ophthalmic Research is chaired by Joe G. Hollyfield, PhD, and has a strong commitment to improving our understanding of the molecular and cellular basis of vision loss and the exploitation of this knowledge for the development of targeted therapeutics. The faculty in the department is involved in multi-disciplinary and highly collaborative approaches using both basic science and clinical investigation, which serves as a basis for exploring and evaluating treatment strategies to slow and prevent vision loss. Disorders currently being investigated include retinitis pigmentosa, macular degeneration (juvenile and age-related forms), diabetic retinopathy, retinopathy of prematurity, vision restoration, ciliopathies, glaucoma, corneal disorders such as transplantation, and wound healing and repair.

Laboratory Goals

Identify and characterize the growth factor-receptor systems through which the functions of corneal, immune, and other cells of the anterior segment of the eye are controlled during development, homeostasis, and wound healing; Understand at the molecular and cellular level, the factors that lead to corneal opacity, and its resolution, after injury, surgery or infection; Explore the mechanism of epithelial basement membrane regeneration after injury and the importance of the corneal epithelial basement membrane in modulating epithelial-stromal interactions in the cornea, including development of myofibroblasts associated with corneal stromal opacity.

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