(LifeScript Health News) Some popular antidepressants, such as Prozac, Zoloft and Paxil, have been linked to bleeding in the upper gastrointestinal tract. Published in Archives of General Psychiatry, the new study found that 5.3% of 1,321 women with upper GI tract bleeding were also taking selective serotonin reuptake inhibitors (SSRIs), a popular class of antidepressants; only 3% of patients with no GI bleeding were taking SSRIs. This translates into a 60% greater risk of developing upper GI tract bleeding when taking SSRIs. The risk is even greater when a person is also taking NSAIDs (non-steroidal anti-inflammatory drugs) or corticosteroids (steroid hormones), while it increases almost tenfold when taking the antidepressants and painkillers without acid-stopping agents, according to the study, conducted by researchers at the Spanish Agency for Medicines and Healthcare Products in Madrid.