Eukaryotic RNA recognition motif profile

Many eukaryotic proteins that are known or supposed to bind single-stranded
RNA contain one or more copies of a putative RNA-binding domain of about 90
amino acids [1,2]. This domain is known as the RNA recognition motif (RRM).

Inside the RRM there are two regions which are highly conserved. The first one
is a hydrophobic segment of six residues (which is called the RNP-2 motif),
the second one is an octapeptide motif (which is called RNP-1 or RNP-CS). The
position of both motifs in the domain is shown in the following schematic
representation:

PROSITE is copyright. It is produced by the SIB Swiss Institute
Bioinformatics. There are no restrictions on its use by non-profit
institutions as long as its content is in no way modified. Usage by and
for commercial entities requires a license agreement. For information
about the licensing scheme send an email to
Prosite License
or see: prosite_license.html.