Fractional anisotropy (FA) in the diffusion tensor
imaging (DTI) is commonly used as a measure of white matter (WM) integrity.
However, FA is also highly sensitive to such factors as non-Gaussian diffusion,
crossing fibers and imaging noise, which may degrade its specificity. It has
recently been proposed that the radial diffusivity is highly related to WM
myelination. Alternatively, PDF measures in the diffusion spectrum imaging
(DSI), e.g. Po and MSD, may provide additional information about WM
microstructure. In this longitudinal study, the dysmyelinating shaking pup
model was studied using both the DTI and DSI acquired from a hybrid diffusion
imaging.