Preacher was published by DC under their Vertigo imprint. It's as far from an indie comic as you can get.

Anyway. I'm a huge fan of the comic. I don't believe a TV series could capture the spirit of the comic, and having watched the first episode, nothing has changed. The show seems to be on a path to make some huge departures from the comic, and I don't think it will remain true to the story: A man who gains power to rival God's own sets out to make God, who has fled Heaven, take responsibility for the suffering He has caused.

Without picking nits, the fact that the first episode opened with a card saying OUTER SPACE and Genesis flying through space instead of having broken out of its prison in Heaven does not bode well.