Specifications: Glutamate Transporter 1 antibody

Glutamate transporters (GluT) function to remove L-glutamate (Glu), the primary excitatory neurotransmitter in the mammalian central nervous system (CNS), from the synaptic cleft. By clearing the synapse in this manner, Glu can be recycled for later use, the proper diffusion gradient can be maintained and excitotoxicity can be prevented. There have been reports of at least three different members of a GluT multigene family; GLT-1, GLAST and EAAC1. mRNA has been identified in brain for each of these proteins, while EAAC1 mRNA has also been shown to be transcribed in other tissues. GLT-1 is translated in numerous CNS regions including cerebellum, thalamus, hippocampus, midbrain and spinal cord. Unmodified GLT-1 has a calculated mass of 62 kDa protein (~75 kDa after post-translational modifications) in rat brain homogenates. A 51 kDa species resulting from an alternate translation initiation site has also been detected in rat brain homogenates.