Summary: In this paper, operator-based reset control for a class of nonlinear systems with unknown bounded disturbance is considered using right coprime factorization approach. In detail, firstly, for dealing with the unknown bounded disturbance of the nonlinear systems, operator-based reset control framework is proposed based on right coprime factorization. By the proposed framework, robust stability of the nonlinear systems with unknown bounded disturbance is guaranteed by using the proposed reset controller. Secondly, under the reset control framework, an optimal design scheme is discussed for minimizing the error norm based on the proposed operator-based reset controller. Finally, for conforming effectiveness of the proposed design scheme, a simulation example is given.