Find Clinical Trials

Utility Actions

Major Depression

Major depression, also known as clinical depression or unipolar depression, is classified as a type of affective disorder or mood disorder that goes beyond the day's ordinary ups and downs, becoming a serious medical condition and important health concern in this country.

Health Care Professionals:

Treatments

Currently Browsing:Obstetrics & Gynecology

The Midlife Women’s Health Center at Massachusetts General Hospital brings together experts from more than 15 specialties to improve, promote and advance healthcare for women at menopause and beyond through research, collaboration and education.

Currently Browsing:Pain Medicine

The Behavioral Medicine Services at the Pain Management Center at Massachusetts General Hospital offer comprehensive assessment and behavioral treatments to patients dealing with chronic pain and related conditions.

Currently Browsing:Pediatrics

The Division of Child and Adolescent Psychiatry at MassGeneral Hospital for Children provides comprehensive evaluation and treatment of children and adolescents with the full spectrum of psychiatric conditions and behavioral or emotional difficulties in both inpatient and outpatient settings.

The pediatric neuropsychology specialists at Massachusetts General Hospital’s Psychology Assessment Center provide neuropsychological assessments to aid in the diagnosis and treatment of neurological, medical, genetic and developmental disorders.

Currently Browsing:Psychiatry

The Division of Child and Adolescent Psychiatry at MassGeneral Hospital for Children provides comprehensive evaluation and treatment of children and adolescents with the full spectrum of psychiatric conditions and behavioral or emotional difficulties in both inpatient and outpatient settings.

About This Condition

Major Depression

What is depression?

Depression is a serious mood disorder that affects your whole body including your mood and thoughts. It touches every part of your life. It’s important to know that depression is not a weakness or character flaw. It’s a chemical imbalance in your brain that needs to be treated.

If you have one episode of depression, you are at risk of having more throughout life. If you don’t get treatment, depression can happen more often and be more serious.

What causes depression?

Depression is caused by an imbalance of brain chemicals. Other factors also play a role. It also tends to run in families. Depression can be triggered by life events or certain illnesses. It can also develop without a clear trigger.

What are the symptoms of depression?

While each person may experience symptoms differently, these are the most common symptoms of depression:

Lasting sad, anxious, or “empty” mood

Loss of interest in almost all activities

Appetite and weight changes

Changes in sleep patterns, such as inability to sleep or sleeping too much

Slowing of physical activity, speech, and thinking OR agitation, increased restlessness, and irritability

Decreased energy, feeling tired or "slowed down" almost every day

Ongoing feelings of worthlessness and/or feelings of undue guilt

Trouble concentrating or making decisions

Repeating thoughts of death or suicide, wishing to die, or attempting suicide (Note: This needs emergency treatment )

If you have 5 or more of these symptoms for at least 2 weeks, you may be diagnosed with depression. These feelings are a noticeable change from what’s “normal” for you.

The symptoms of depression may look like other mental health conditions. Always see a healthcare provider for a diagnosis.

How is depression diagnosed?

Depression can happen along with other medical conditions. These include heart disease, or cancer, as well as other mental health conditions. Early diagnosis and treatment is key to recovery.

A diagnosis is made after a careful mental health exam and medical history done. This is usually done by a mental health professional.

How is depression treated?

Treatment for depression may include one or a combination of the following:

Medicine. Antidepressants work by affecting the brain chemicals. Know that it takes 4 to 6 weeks for these medicines to have a full effect. Keep taking the medicine, even if it doesn’t seem to be working at first. Never stop taking your medicine without first talking to your healthcare provider. Some people have to switch medicines or add medicines to get results. Work closely with your healthcare provider to find treatment that works for you.

Therapy. This is most often cognitive behavioral and/or interpersonal therapy. It focuses on changing the distorted views you have of yourself and your situation. It also works to improve relationships, and identify and manage stressors in your life.

Electroconvulsive therapy (ECT). This treatment may be used to treat severe, life-threatening depression that has not responded to medicines. A mild electrical current is passed through the brain. This triggers a brief seizure. For unknown reasons, the seizures help restore the normal balance of chemicals in the brain and ease symptoms.

With treatment, you should feel better within a few weeks. Without treatment, symptoms can last for weeks, months, or even years. Continued treatment may help to prevent depression from appearing again.

Depression can make you feel exhausted, worthless, helpless, and hopeless. It’s important to realize that these negative views are part of the depression and do not reflect reality. Negative thinking fades as treatment begins to take effect. Meanwhile, consider the following:

Get help. If you think you may be depressed, see a healthcare provider as soon as possible.

Set realistic goals in light of the depression and don’t take on too much.

Break large tasks into small ones. Set priorities, and do what you can as you can.

Try to be with other people and confide in someone. It’s usually better than being alone and secretive.

Do things that make you feel better. Going to a movie, gardening, or taking part in religious, social, or other activities may help. Doing something nice for someone else can also help you feel better.

It is best to delay important decisions until the depression has lifted. Before deciding to make a big change --change jobs, get married or divorced -- discuss it with others who know you well and have a more objective view of your situation.

Remember: People don’t "snap out of" a depression. But they can feel a little better day-by-day.

Try to be patient and focus on the positives. This may help replace the negative thinking that is part of the depression. The negative thoughts will fade as your depression responds to treatment.

Let your family and friends help you.

When to call your healthcare provider

If you have 5 or more of these symptoms for at least 2 weeks, call your healthcare provider:

Lasting sad, anxious, or “empty” mood

Loss of interest in almost all activities

Appetite and weight changes

Changes in sleep patterns, such as inability to sleep or sleeping too much

Slowing of physical activity, speech, and thinking OR agitation, increased restlessness, and irritability

Decreased energy, feeling tired or "slowed down" almost every day

Ongoing feelings of worthlessness and/or feelings of undue guilt

Trouble concentrating or making decisions

Repeating thoughts of death or suicide, wishing to die, or attempting suicide (Note: This needs emergency treatment )

Key points about depression

Depression is a serious mood disorder that affects your whole body including your mood and thoughts.

It’s caused by a chemical imbalance in the brain. Some types of depression seem to run in families.

Depression causes ongoing, extreme feelings of sadness, helplessness, hopeless, and irritability. These feelings are usually a noticeable change from what’s “normal” for you, and they last for more than two weeks.

Depression may be diagnosed after a careful psychiatric exam and medical history done by a mental health professional.

Depression is most often treated with medicine or therapy, or a combination of both.

Next steps

Tips to help you get the most from a visit to your healthcare provider:

Know the reason for your visit and what you want to happen.

Before your visit, write down questions you want answered.

Bring someone with you to help you ask questions and remember what your provider tells you.

At the visit, write down the name of a new diagnosis, and any new medicines, treatments, or tests. Also write down any new instructions your provider gives you.

Know why a new medicine or treatment is prescribed, and how it will help you. Also know what the side effects are.

Ask if your condition can be treated in other ways.

Know why a test or procedure is recommended and what the results could mean.

Know what to expect if you do not take the medicine or have the test or procedure.

If you have a follow-up appointment, write down the date, time, and purpose for that visit.

News

Becoming a mom can be overwhelming. Sleepless night, developing a new routine and learning an infant’s queues can lead to anxiety and stress. For infants with unexpected health complications, their parents worry only multiplies. That was case for Memmolo family.

Drs. Warren Zapol and Ryan Carroll of the Anesthesiology Center for Critical Care Research and are currently leading a phase II clinical trial in the safety and efficacy of inhaled nitric oxide as an adjunctive treatment for pediatric patients with cerebral malaria in Uganda (ClinicalTrial.gov: NCT01388842).