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Research Interests

Research in my laboratory focuses on two subtypes of high risk leukemia: MLL-rearranged (MLL-r) infantile acute lymphoblastic leukemia (ALL) and acute megakaryoblastic leukemia in non-Down syndrome patients (non-DS AMKL). These malignancies are driven by recurring chromosomal abnormalities that create the novel fusion genes MLL-AF4 (in MLL-r infant ALL) and CBFA2T3-GLIS2 (in non-DS AMKL). Our focus is on the mechanism whereby these fusions contribute to leukemogenesis with the long term goal of defining pathways and/or proteins to target therapeutically.