Before Using

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies on the relationship of age to the effects of cyclosporine injection have not been performed in the pediatric population. However, no pediatric-specific problems have been documented to date.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of cyclosporine injection in the elderly. However, elderly patients are more likely to have high blood pressure or age-related kidney, liver, or heart problems, which may require caution and an adjustment in the dose for patients receiving cyclosporine injection.

Pregnancy

Information about this cyclosporine-intravenous-route

Pregnancy Category

Explanation

All Trimesters

C

Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

Amifampridine

Bosentan

Colchicine

Dronedarone

Mifepristone

Pitavastatin

Simvastatin

Sitaxsentan

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Aceclofenac

Acemetacin

Adalimumab

Afatinib

Alefacept

Alfalfa

Aliskiren

Amlodipine

Amtolmetin Guacil

Apixaban

Aspirin

Atorvastatin

Bacillus of Calmette and Guerin Vaccine, Live

Black Cohosh

Blinatumomab

Bromfenac

Bufexamac

Bupropion

Carbamazepine

Caspofungin

Celecoxib

Ceritinib

Cerivastatin

Cholic Acid

Choline Salicylate

Clonixin

Cobicistat

Crizotinib

Cyclophosphamide

Dabigatran Etexilate

Dabrafenib

Dasabuvir

Dexibuprofen

Dexketoprofen

Diclofenac

Diflunisal

Diltiazem

Diphtheria Toxoid, Adsorbed

Dipyrone

Domperidone

Donepezil

Doxorubicin

Doxorubicin Hydrochloride Liposome

Droxicam

Efavirenz

Eliglustat

Eluxadoline

Enzalutamide

Etodolac

Etofenamate

Etoposide

Etoricoxib

Etravirine

Felbinac

Felodipine

Fenoprofen

Fentanyl

Fepradinol

Feprazone

Floctafenine

Fluconazole

Flufenamic Acid

Flurbiprofen

Foscarnet

Golimumab

Haemophilus B Vaccine

Hepatitis A Vaccine, Inactivated

Ibuprofen

Ibuprofen Lysine

Idelalisib

Indomethacin

Infliximab

Influenza Virus Vaccine

Isavuconazonium Sulfate

Itraconazole

Ketoprofen

Ketorolac

Lanreotide

Lornoxicam

Lovastatin

Loxoprofen

Lumacaftor

Lumiracoxib

Lyme Disease Vaccine (Recombinant OspA)

Measles Virus Vaccine, Live

Meclofenamate

Mefenamic Acid

Meloxicam

Meningococcal Vaccine

Morniflumate

Morphine

Morphine Sulfate Liposome

Mumps Virus Vaccine, Live

Mycophenolic Acid

Nabumetone

Nafcillin

Naproxen

Nepafenac

Niflumic Acid

Nimesulide

Nintedanib

Octreotide

Ombitasvir

Osimertinib

Oxaprozin

Oxyphenbutazone

Parecoxib

Paritaprevir

Pazopanib

Perindopril

Pertussis Vaccine

Phenylbutazone

Piketoprofen

Piperaquine

Piroxicam

Pixantrone

Plague Vaccine

Pneumococcal Vaccine, Diphtheria Conjugate

Pneumococcal Vaccine Polyvalent

Poliovirus Vaccine, Live

Posaconazole

Pravastatin

Proglumetacin

Propionic Acid

Propyphenazone

Proquazone

Pyrazinamide

Rabies Vaccine

Ranolazine

Red Yeast Rice

Rifabutin

Rifampin

Ritonavir

Rofecoxib

Romidepsin

Rosuvastatin

Rotavirus Vaccine, Live

Rubella Virus Vaccine, Live

Salicylic Acid

Salsalate

Secukinumab

Silodosin

Siltuximab

Simeprevir

Smallpox Vaccine

Sodium Salicylate

St John's Wort

Sulfinpyrazone

Sulindac

Tacrolimus

Telaprevir

Telithromycin

Tenoxicam

Tetanus Toxoid

Tiaprofenic Acid

Tolfenamic Acid

Tolmetin

Topotecan

Typhoid Vaccine, Live

Valdecoxib

Varicella Virus Vaccine

Vilazodone

Vincristine

Vincristine Sulfate Liposome

Voriconazole

Yellow Fever Vaccine

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Acetazolamide

Allopurinol

Ambrisentan

Amiodarone

Amphotericin B

Amphotericin B Cholesteryl Sulfate Complex

Amphotericin B Lipid Complex

Amphotericin B Liposome

Amprenavir

Boceprevir

Bromocriptine

Chloramphenicol

Chloroquine

Cimetidine

Ciprofloxacin

Cisapride

Clarithromycin

Clonidine

Colesevelam

Dalfopristin

Danazol

Desogestrel

Dienogest

Digoxin

Dirithromycin

Drospirenone

Erythromycin

Estradiol Cypionate

Estradiol Valerate

Ethinyl Estradiol

Ethynodiol Diacetate

Etonogestrel

Everolimus

Ezetimibe

Famotidine

Fenofibrate

Fluvoxamine

Fosamprenavir

Fosphenytoin

Furosemide

Glipizide

Glyburide

Imipenem

Indinavir

Josamycin

Ketoconazole

Levonorgestrel

Medroxyprogesterone Acetate

Mestranol

Methotrexate

Methylprednisolone

Metoclopramide

Metronidazole

Mibefradil

Midazolam

Miokamycin

Modafinil

Mycophenolate Mofetil

Nefazodone

Nelfinavir

Nevirapine

Nicardipine

Norelgestromin

Norethindrone

Norfloxacin

Norgestimate

Norgestrel

Oxypurinol

Phenytoin

Probucol

Propafenone

Quinine

Quinupristin

Repaglinide

Rifapentine

Saquinavir

Sulfadiazine

Sulfasalazine

Terbinafine

Tobramycin

Tolterodine

Troglitazone

Verapamil

Warfarin

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

Allergy to polyoxyethylated castor oil (Cremophor® EL)—Should not be used in patients with this condition.

Anemia or

Bleeding problems or

Brain disease (e.g., encephalopathy) or

Cancer or

Eye or visual problems (e.g., papilloedema) or

Hyperkalemia (high potassium in the blood) or

Hypertension (high blood pressure) or

Hyperuricemia (too much uric acid in the blood) or

Kidney disease or

Liver disease or

Precancerous skin changes or

Seizures, history of or

Thrombocytopenia (low number of platelets)—Use with caution. May make these conditions worse. .

Hypertension (high blood pressure) or

Hypocholesterolemia (low cholesterol in the blood) or

Hypomagnesemia (low magnesium in the blood)—May increase risk for encephalopathy.