Avoid letting her harass you for free, as it will lower her Mantra's cooldown.
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340

Try your best to escape from her Focused Resolve when she casts it on you, as it will root you after a short while.Report

331

Leave the circle from her Mantra Inner Flame as it will deal bonus damage in the circle after a short duration.
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37

Most effective poke for Karma is her Q. Esp. when she has Inner Flame on. I personally only use that to poke to save mana. Bait that poke early game before you dive. It does serious dmg and can slow you for lots of AA cooldownReport