The aim of this non-investigational study is to determine the symptoms and disease burden at
the time point of diagnosis and in the further course of an incurable cancer disease. The
needs and preferences of patients suffering from cancer (ovarian carcinoma, breast cancer,
malignant melanoma, lung cancer, stomach cancer, oesophageal cancer, pancreatic cancer,
cancer of the hepatobiliary system, colorectal cancer, head and neck cancer) are examined by
various validated questionn...

The emergence of oral delivery in cancer therapeutics is expected to result in an increased
need for better coordination between all treatment stakeholders, mainly to ensure adequate
treatment delivery to the patient. There is significant interest in the nurse navigation
program's potential to improve transitions of care by improving communication between
treatment stakeholders and by providing personalized organizational assistance to patients.
The use of health information te...

The purpose of this study is to find out what effects, good and bad, the medication Albumin
has on subjects who have experienced a type of stroke known as an intracerebral hemorrhage
(ICH). An ICH is when spontaneous bleeding into the brain occurs due to fragile blood
vessels.
This research is being done because currently there is no effective treatment for ICH.
However, study investigators believe that Albumin, the medication being tested in this
study, is safe and may...

DASAP-HF is an observational prospective single arm study. All patients will be treated
according to the standard care followed by each center. The protocol requires enrollment of
consecutive patients from each center, according to eligibility criteria. All patients must
sign the Patient Informed Consent (PIC) before the enrollment in the study. All patients,
after the enrollment phase, will be followed for 24 months. Approximately every 12 months a
clinical follow-up procedure...

This is a Feasibility/Phase II study for patients with a diagnosis of WHO Grade I - III
Meningioma & Hemangiopericytoma brain cancer to be given standard dose Proton radiotherapy.
The study will be performed in two phases: first, feasibility with an enrollment of 12
patients and then Phase Page 8 of 20 II, with an enrollment of an additional 38 patients.
All patients will also be given quality of life (QOL) instruments pretreatment, weekly
during treatment, then q 3 months for ...

The goal of this study is to compare patient ratings of how severe their own symptoms may
be, with their caregivers' ratings of how severe they think the patients' symptoms may be.
This will be compared using a questionnaire that is given to patients with brain tumors and
their caregivers.
Researchers will also study any effects that these patients' neurocognitive function may
have on these patients' and their caregivers' ratings of how severe the brain cancer
symptoms m...

Decisions to limit and stop active therapeutics are common in the emergency unit. They are
framed by the Leonetti law of 22 April 2005 recommending the refusal of unreasonable
obstinacy and care of the patient's pain in later life. The pain assessment is an issue for
these patients whose in majority, are not communicating. Moreover, no specific tool and the
teams in charge, not knowing the patient make the recognition and treatment of pain symptoms
very complex. This is the pot...

The primary purpose of this study is to determine if it is effective to take samples of
fluid from the patient's brain tumor with a microdialysis catheter for Torisel measurement.
The investigators are also doing it to learn if it is safe to do so. The investigators will
use these samples to measure how much Torisel reaches the patient's brain tumor. The use of
the microdialysis catheter to collect brain fluid is an FDA approved method. This catheter
is already being used in pa...

This clinical trial is being done to learn more about how different types of cancer
treatments affect cancer cells when they spread to the brain. Many cancer treatments are not
able to make their way into the brain or into spinal fluid of the central nervous system.
This is because they cannot cross what is called the "blood-brain barrier" or "BBB". The BBB
is like a protective shield that only allows certain materials pass through to reach the
brain but not others. This study ...

This is a observational study in a real-world setting, not requiring determining a dosage
regimen, dose reduction criteria, rest period criteria and withdrawal criteria. The purpose
of the study is to investigate the efficacy of eribulin as the first or second line
chemotherapy to prolong overall survival and to explore factors affecting the survival in
patients with HER2-negative hormone-resistant inoperable or recurrent metastatic breast
cancer who scheduled to receive the fi...

The purpose of this epidemiologic study is to establish a population-based cohort of women
with advanced stage breast cancer which can be used to quantify the frequency and timing of
brain metastases, and other distant metastases, in this patient population.

This retrospective cohort study aims to improve our understanding of the current paradigm
for treatment of brain metastases in erbB2+ breast cancer patients in the Asia Pacific
region. We aim to identify approximately 300 erbB2+ breast cancer patients with brain
metastases diagnosed between 2006-2008 in 6 countries. Medical records will be analyzed to
determine the treatment pattern for brain metastases, including anti-erbB2 therapy.
Additional objectives are to understand the ...

This is a prospective, national, multicenter, non-interventional study designed to enroll
participants who have an initial diagnosis of unresectable LA/mBC made up to 6 months prior
to registry enrollment. These participants will be prospectively followed for at least 5
years after study enrollment to evaluate their anti-cancer treatments. Data on participants'
previous anti-cancer treatments for breast cancer will be collected retrospectively at study
entry.

The purpose of the study is to determine the safety and efficacy of an investigational
therapy called DCVax(R)-Brain in patients with newly diagnosed GBM for whom surgery is
indicated. Patient must enter screening at a participating site prior to surgical resection
of the tumor. Patients will receive standard of care, including radiation and Temodar
therapy and two out of three will additionally receive DCVax-Brain.

This study will investigate how patients are informed of their cancer diagnosis or
recurrence and will explore their experience in learning about the diagnosis. Specifically,
it will:
- Distinguish methods of telling the diagnosis and identify its relationship to the type
of cancer.
- Determine if the way a patient is informed of their diagnosis is associated with their
level of satisfaction with the method of being informed.
- Identify who inf...

The purpose of this research study is to determine the safety of combining lapatinib plus
radiation in patients with breast cancer that has spread to the brain. Depending upon the
participants cancer, they may also have stereotactic radiosurgery (SRS). Lapatinib s a
compound that may stop cancer cells from growing abnormally. It is thought that lapatinib
might also make cancer cells more sensitive to radiation. This drug has been used in other
research studies in women with...

The objective of this study is to explore the experience of informal caregivers of patients
with a primary brain tumor, identifying elements and themes of the caregiving experience
specific to this population of caregivers. The aim is to describe the experience of being
an informal caregiver for a patient with a primary brain tumor.

The investigators will focus on two cohorts of brain tumor patients aged, 4-18 years, to
answer two critical questions: 1) Can the investigators acquire high quality data relevant
to cognitive function during the peri-diagnostic period and, 2) can the investigators
develop predictive models for cognitive outcomes using serial examination of functional
imaging and cognitive function. Any patient with a newly diagnosed brain tumor aged 4-18
will be eligible for enrollment in coho...

Identifying the optimal time of extubation in a brain injured population should improve
patient outcome. Brain injured patients usually remain intubated due to concerns of airway
maintenance. Current practice argues that unconscious patients need to remain intubated to
protect their airways. More recent data however suggests that delaying extubation in this
population increases pneumonias and worsens patient outcomes.
We designed a safety and feasibility study of randomizing b...

the aim of this study is to measure brain metabolism in patients with lung cancer.FDG uptake
in the brain in patients with malignant tumors will be compared to the amount of tracer
activity found in patients who have benign pulmonary process. if differences between the
brain uptake of FDG in the two groups will be found, further assessment will be performed in
order to evaluate if such differences could be attributed and specifically localized to the
brain regions innervated by...

Stereotactic radiosurgery (SRS) is increasingly administered as the sole treatment of brain
metastases, in order to spare acute and long term side effects associated with whole brain
radiotherapy. Local control of SRS treated lesions is good, but patients tend to develop
additional brain metastases subsequently.
Nivolumab is a modulator of the immune system. Treatment with Nivolumab is associated with
an increase in local control and survival in patients with non-small cell lu...

REVOLUTION will be a US multicenter observational registry in scope and governed by a
steering committee of approximately 8 experts in NSCLC and outcomes research. The primary
goal of the registry is characterizing patterns of use for NSCLC therapy. REVOLUTION will be
a multicenter registry enrolling approximately 2,500 patients. Additional patients limited
to those with EGFR mutations may be enrolled following the initial study period as needed to
ensure adequate sample sizes ...

Patients enrolled in this study will not receive investigational therapy. Any treatments
rendered will be standard and based on appropriate medical care. Should a patient become
eligible for an experimental therapy protocol, the normal process of enrollment and informed
consent will be followed.

The current prognosis for patients with metastatic brain cancer from NSCLC is very poor.
The current standard treatment for this disease is radiation therapy to the brain. The goal
of the current study is to test whether the combination of orally administered HYCAMTIN
capsules and whole brain radiation therapy will prolong the survival time of patients with
this potentially serious condition.