Dario Vignali, Ph.D.
Vice Chair and Member
Department of Immunology
St. Jude Children’s Research Hospital

“Tregs, IL-35 and iTr35: A Regulatory Triad”

Regulatory T cells (Tregs) have a critical role in the maintenance of immunological self-tolerance.

We have described a novel inhibitory cytokine IL-35, that is produced by Tregs and can mediate the development of an IL-35-induced regulatory population, which we call ‘iTr35’.

I propose that Tregs, IL-35 and iTr35 form a regulatory triad that controls immune responses in tumors and during mucosal infections. I will also discuss the therapeutic implication of our recent findings.