Last Episode of Toradora, I was actually pissed about to throw my computer out the window till I saw the Scene after the Credits.
Myself & yourself
High School Days - this show actually freak me out last episode I was like WHAT???????
H20 Foot prints on the sand

Just finished that anime a couple days ago, and, yeah. I've seen Clannad and Angel Beats and AnoHana, and cried watching all of those too, but episode 23 of The Pet Girl of Sakurasou was probably the most moving 20-odd minutes I've ever seen. That graduation speech was. Just. Beautiful.

I thought there was a longer thread for this somewhere, but I can't find it (went back through 35 pages).

Anyhoo, bump:

Ame Yuki: Wolf Children.

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When Ame carries Hana down off the mountain and lays her in the carpark, I was sure she was dead so I was all walled up; but then the camera turned around and she started moving and I started bawling my eyes out.

Remember that episode of Fist of the North Star where Kenshiro and the gang are out rescuing Toki, when suddenly Roah and his Armies attack the village, and start killing of random NPC's?

Oh! Fist of the North Star Spoilers ahe.....why should I even bother? Ain't none of half of you seen it, and the lot of you never will. Even if you do, this happens far enough in you'll forget about it by the time it happens.

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When the village gets attacked. Lin sacrifices herself and gets captured to make sure Airi isn't captured as well. Now, Airi is a solid 22 year old woman, while Lin is an 11-year old girl.

Lin is then bitch-slapped by some 9 foot tall giant mook, and rounds her up with the rest of the village where she's to pledge loyalty to Roah, just like the rest of the village.
Now at this point, half the village is dead, and the other half was branded with this mark. Of course, Roah doesn't want unwilling followers, you're free to choose death over marking yourself, they won't force you to follow him. He's just going to kill you if you don't.

And Lin claims that becoming enslaved to a demon is far worse than death, and gladly decides to die instead.

And then Rei comes in and starts kicking some major ass.

And like damn, made me want to Cosplay Rei like, hella bad.

No? Nobody else remembers that?

I mean sure, I like, just saw it yesterday...but now that I've seen it, I am NOT forgetting that. That was one hell of a scene!

Sword Art Online Episode 3: Red Nosed Reindeer. (AKA: The death of Sachi) ='(
This episode genuinely upsets me every time I watch it, Sachi is by far my favorite female anime character of all time and frankly I find her death to have been rather unfair..

WARNING: Spoilers below!To save space I grouped them into 3 each.Avoid the shows you don't know. Since I've made it convenient to avoid, getting spoiled is your fault.

Clannad, Anohana, and Fate/Zero

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Clannad After Story

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Nagisa and Ushio's deaths. Nagisa's in particular, even though it got spoiled for me. Also the trip to the flower field. (After Story episodes 16, 18, and 21)

AnoHana

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Last episode. My senior retreat in high school was a sob-fest like the beginning of the episode, so this one hit home. And as for a sob-fest, imagine 100 students in one room all bawling their a**es off. (episode 11)

Fate/Zero

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If you didn't shed man-tears when Rider died, I don't know what to say to you. (S2 episode 10)

Madoka, Chuunibyou, and FMA Brotherhood

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Madoka Magica

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Kyouko's death and episode 10 (the episode where it explains what Homura went through). Specifically the scene where she has to finish off a wounded Madoka. (episodes 9 and 10)

Chuunibyou

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"Goodbye, papa" (episode 12)

FMA Brotherhood

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Hohenheim's death in front of the grave and Hughes' funeral. (episodes 11 and 63)

Higurashi, Sakurasou, and TWGOK

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Higurashi

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The second arc in Kai, when everyone gets killed by Takano. (Kai episode 13)

Sakurasou

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When Aoyama loses it after bottling it up for so long. And the graduation ceremony. (S2 episodes 9 and 11)

TWGOK

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The end of the concert. Chihiro ftw! (S3 episode 12)

Death Note, SAO, and Naruto

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Death Note

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L's Death (episode 25)

Sword Art Online

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Asuna's "death", but then after I found out it was BS I got pissed off instead XD (episode 14)