Polyclonal Antibody to SIRPα (CT)

PSC-1125-C020

20 µg

87.00 USD

PSC-1125-C100

100 µg

369.00 USD

Protein tyrosine phosphatases (PTPases) SHP-1 and SHP-2 are critical regulators in the intracellular signalling pathways that result in cell responses such as mitosis, differentiation, migration, survival, transformation or death. SHP-2 is a signal transducer for several receptor tyrosine kinases and cytokine receptors. A novel SHP-2 associated glycoprotein was cloned from human, rat, mouse and cattle and was designated SIRPα [1], SHPS-1 [2,3], MyD-1 [4], BIT [5,6] and p84 [7], respectively SIRPα is a new gene family containing at least fifteen members.

SIRPα is a substrate of many activated tyrosine kinases such as insulin receptor, EGF-R, PDGF-R and src [1,2,5,8]. SIRPα has regulatory effects on cellular responses induced by serum, growth factors, insulin, oncogenes, growth hormones and cell adhesion and plays a general role in different physiological and pathological processes [1,2,5,8].

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FIGURES

Figure: Western blot analysis of SIRPa in THP-1 whole cell lysate with anti-SIRPa at 1:2000 dilution.

Product Literature References

Cloning of two members of the SIRP alpha family of protein tyrosine phosphatase binding proteins in cattle that are expressed on monocytes and a subpopulation of dendritic cells and which mediate binding to CD4 T cells: G.P. Brooke, et al.; Eur. J. Immunol. 28, 1 (1998), Abstract;