The article presents an overview of Langerhans cell histiocytosis, which is a non-neoplastic disease of unknown etiology that is characterized by a clonal proliferation of Langerhans histiocytes. The case of a ten year old boy who presented to doctors with symptoms of neck pain associated with slight restriction of head rotation and who was diagnosed with and treated for Langerhans cell histiocytosis of the atlas in his spine, is presented.

ACCESSION #

34230460

Related Articles

Epidermal Langerhans cells (LC) are related to certain cells of the monocyte-macrophage lineage and to other dendritic cells. While epidermal LC and macrophage bear receptors for the Fc portion of IgG, other dendritic cells do not. However, unlike human dendritic cells from peripheral blood, LC...

Many details of the pathogenesis of the human immunodeficiency virus type 1 remain to be elucidated. Details of how the virus gains entry via the mucosal surface upon sexual contact or during breast feeding remain obscure. The means by which the infection travels throughout the body as well as...

Ex vivo foreskin models have demonstrated that inner foreskin is more susceptible to HIV-1 infection than outer foreskin. In the present study we characterized the compartition of HIV-1 target cells and quantified these cells in the epidermis and dermis of inner and outer foreskins using...

Langerhans' cell histiocytosis (LCH) describes a group of conditions affecting the reticuloendothelial system. It includes the subtypes of Letterer-Siwe disease, Hand-Schuller-Christian disease and eosinophilic granuloma and most often presents in childhood. Intracranial involvement in LCH is...

Abstract: We describe the case of a 55-year-old man who presented with parasternal swelling. The chest CT scan showed a large tumor of the chest wall infiltrating the subcutaneous tissue. To assume histologic diagnosis an open biopsy was performed. Between the myofibrils a coarse, white tumor...

Langerhans cell histiocytosis (LCH), mainly affects the skull, vertebrae, ribs and mandible in children and the long bones of adults. Symptoms range from none to pain, swelling and tenderness over the site of the lesion. This disease presents oral manifestations which can sometimes be the first...

The distribution of Langerhans cells in normal and carcinogen-treated mucosa of buccal pouches of hamsters was studied. Decrease in density and in focal aggregates of Langerhans cells and loss of their complex dentritic networks were found in carcinogen-treated mucosa.

Epidermal Langerhans cell (ELC) densities are markedly reduced in a number of clinical situations including anergic sarcoidosis patients. To help determine whether this reduction is related to the anergic or nutritional status of the patient, we examined the non-sun-exposed epidermis of 23...