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Suggested withdrawal times and threshold concentrations of therapeutic medications

Detection of a therapeutic substance at concentrations higher than the reported threshold will result in sanctions, according to the Mid-Atlantic Uniform Medication and Testing Program. (LOD = level of detection.)

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Drug

Dose/Route

Withdrawal (no pre-race treatment within)

Threshold

Acepromazine

0.05 mg/kg IV (single dose)

48 hours

10 ng/ml HEPS (applicable metabolite) in urine

Betamethasone

9 mg IA only—1 joint

7 days

10 pg/ml of plasma or serum

Butorphanol

0.1 mg/kg IV (single dose)

48 hours

300 ng/ml of total butorphanol in urine, or 2 ng/ml of free butorphanol in plasma

Clenbuterol

0.8 µg/kg PO twice daily

14 days

140 pg/ml of urine or LOD in plasma or serum

Dantrolene

500 mg PO

48 hours

100 pg/ml 5-hydroxydantrolene in plasma or serum

Detomidine

40 µg/kg single sublingual dose

72 hours

LOD in plasma or 1 ng/ml of carboxydetomidine in urine

Dexamethasone

0.05 mg/kg IV, IM, PO

72 hours

5 pg/ml of plasma or serum

Diclofenac (topical)

5-in ribbon topically

48 hours

5 ng/ml of plasma or serum

DMSO

PO, IV

48 hours

10 µg/ml of plasma or serum

Firocoxib

0.1 mg/kg PO daily for four days

14 days

20 ng/ml of plasma or serum

Flunixin

1.1 mg/kg IV single dose

24 hours

20 ng/ml of plasma or serum

Furosemide

Maximum 500 mg IV single dose

4 hours

100 ng/ml of plasma or serum

Glycopyrrolate

1 mg IV single dose

48 hours

3 pg/ml of plasma or serum

Ketoprofen

2.2 mg/kg IV single dose

24 hours

10 ng/ml of plasma or serum

Lidocaine

200 mg SC

72 hours

20 pg/ml of total 30H-lidocaine in plasma

Mepivacaine

0.07 mg/kg SC single dose

72 hours

10 ng/ml of total hydroymepivacaine in urine or LOD in plasma

Methocarbamol

0.15 mg/kg single dose IV or 5 g orally

48 hours

1 ng/ml of plasma or serum

Methylprednisolone* (IA only)

100 mg—1 joint

21 days*

100 pg/ml in plasma or serum

Omeprazole

3.9 mg/kg PO single dose

24 hours

1 ng/ml of urine

Phenylbutazone (IV only)

2.2 mg/kg IV single dose

24 hours

2 µg/ml of plasma or serum

Prednisolone

1 mg/kg PO

48 hours

1 ng/ml plasma or serum

Procaine penicillin**

IM

Entry**

25 ng/ml of plasma

Triamcinolone acetonide

9 mg IA—1 joint

7 days

100 pg/ml of plasma or serum

Xylazine

IV

48 hours

0.01 ng/mg of plasma or serum

*Methylprednisolone following intraarticular administration of 100 mg can be detected at 100 pg/ml for up to 21 days. Its use is therefore problematic.