Washington DC to Orlando is an approximately 14-hour car ride. You can also take a train; or take a bus. Expect a bit warmer temperatures when traveling from Washington DC in April; daily highs in Orlando reach 84°F and lows reach 65°F. Cap off your sightseeing on the 16th (Mon) early enough to go by car to Key West.

Traveling by car from Orlando to Key West takes 7.5 hours. Alternatively, you can take a bus; or do a combination of train and bus. Traveling from Orlando in April, you can expect nighttime temperatures to be a bit warmer in Key West, with lows of 74°F. Cap off your sightseeing on the 17th (Tue) early enough to travel back home.