P01-012 – Evaluation of autonomic function in FMF

Introduction

Familial Mediterranean fever (FMF) is characterized by acute and recurrent attacks of fever and polyserositis. It is associated with conduction disturbances and rhythm abnormalities. Heart rate variability (HRV) is the term used to indicate the fluctuation in cardiac frequency over time. HRV analysis is used to evaluate the condition of the autonomous nervous system, which regulates general cardiac condition and cardiac activity. Significant correlations between cardiovascular mortality and the autonomous nervous system have been evidenced in the last twenty years. In adult FMF patients abnormal heart rate variability (HRV) parameters were found, suggesting to autonomic dysfunction.

Objectives

Methods

A prospective randomized clinical trial was performed by a tertiary referral pediatric cardiology and a pediatric rheumatology center. The study group consisted of 53 patients with FMF (28 female, 25 male) that were followed-up by the pediatric rheumatology out-patient clinic. They were all under colchicine treatment. The control group was chosen from age and sex matched 44 healthy children (21 female, 23 male). All participants underwent 24-hour Holter rhythm monitoring (CardioNavigator Plus Impresario Medical Spider view, 3.07.0158, Delmar Reynolds; Paris, France). The HRV parameters were evaluated in both groups.

Conclusion

Autonomic nervous system has an important role in the supervision of cardiac functions. In adult patients with uncomplicated FMF there are two published studies about the autonomic dysfunction, one revealing autonomic indices abnormalities and the other with similar normal autonomic function compared to healthy subjects. As being the first study concerning the autonomic function in children with FMF, we had found no significant differrences between both groups. This may be atrributed to the shorter duration and uncomplicated course of disease in children with FMF.

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Corresponding author

Correspondence to
N Aktay Ayaz.

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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.