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Never made my legs hurt. You're more than likely just more sensitive to how your body feels. Psilocybin is several hundred places lower in the physical toxicity list than aspirin. There's nothing in it going to make your legs hurt.

Mine feel restless and sometimes a bit achey the next day but that probably comes from running about like a nutter. One of my mates gets pains in his calves though, he's had it a couple of times, and one time he didn't trip, he just felt the pain. It wasn't so bad that he couldn't laugh about it "I feel so good, as if my legs are about to cramp at any time!"