Respiratory-Swallow Training in Veterans With Oropharyngeal Cancer

Trial Information

Respiratory-Swallow Training in Veterans With Oropharyngeal Cancer

Swallowing impairments (dysphagia) represent the highest functional morbidity in veteran patients treated for oropharyngeal cancers with either surgical approaches followed by radiation or with more recent organ-preservation protocols. The nature of the impairments is often resistive to treatment and results in life-long health consequences and high cost burden on the VA health system. Recent preliminary data have linked alterations in the otherwise highly stable respiratory-swallowing phase pattern relationships to the swallowing impairment and penetration/aspiration and in this patient group. The immediate goal of this clinical trial is to test the effect of a novel respiratory-swallow intervention on swallowing impairment and penetration/aspiration in a cohort of chronically dysphagic veterans following treatment for oropharyngeal cancer. Patients presenting with a "non-optimal" respiratory-swallow phase pattern during liquid swallows and measurable swallowing impairment will learn an "optimal" physiologic pattern that facilitates both airway protective and mechanical advantages during swallowing. The broad goal of this research is to develop ideal respiratory-swallowing phase training methods and regimens that alone or combined with traditional swallowing treatments improve swallowing function in the acute phases of recovery and improve long term patient outcome. Our intention is to use these preliminary data to motivate a larger clinical trial to compare the effect of respiratory-swallow phase training with other evidenced based methods of swallowing treatment and expand the approach to other patient groups that have indications of respiratory-swallow phase impairments (e.g. pulmonary disease and stroke) contributing to impaired swallowing function

Inclusion Criteria:

- at least 21 years of age

- agreed to participate in this study and signed an informed consent, either completed by the participant or designated other

- have chronic impairments in oropharyngeal swallowing function following chemotherapy, radiation, and/or surgical intervention for the treatment of first time diagnosis of squamous cell carcinoma of the head and neck

- have at least one area of impairment (initiation of pharyngeal swallow, anterior hyolaryngeal excursion, extent and duration of PES opening, tongue base retraction, pharyngeal residue) as indicated by the results of the pre-intervention MBSImP (total sum MBSImP

- have PAS scores >/= 3 on 10% of swallows on pre-intervention MBSS

- have a non-optimal (E-I, I-E, or I-I) breathing pattern on 60% of trial swallows.

Exclusion Criteria:

- known allergy or dietary restriction for food or contrast materials used during the exam

- evidence of persistent or recurrent disease on physical examination of the head and neck

- evidence of esophageal stricture noted on MBS

- recurrent oropharyngeal cancer and/or are being treated for other cancer(s) concurrently

- severe COPD (see Pulmonary Criteria below)

- nasogastric feeding tube

- recent change in swallowing status characterized by increase in perceived or observed -swallowing problems by patient, family or testing SLP

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