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CCL19 IL2/PHA The majority of the genes near integration sites in all in vitro conditions were involved in cellular housekeeping activities and cell signaling pathways. Unactivate CCL19 No differences in expression of genes near integration sites in different in vitro conditions Gene expression (heat map)

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Conclusions and implications Sites of integration of HIV-1 might be determined by activation state of the cell at the time of infection. Differing sites of integration may have implications for designing strategies to reverse latency.