TCR Annual Report (2017)

Greetings from Editors-in-Chief and Editorial Office of TCR!We are pleased to share the 2017 Annual Report of Translational Cancer Research here. We would especially like to express our sincere gratitude to the editorial board members, guest editors, reviewers, authors and readers for all your support and contributions to TCR. We wish you a happy, healthy and prosperous 2018!For detailed information, please find attached the Annual Report below.

This focused issue of Translational Imaging in Cancer Patient Care highlights current topics in the field of imaging addressing many common and debilitating oncological conditions. The authors have succeeded in covering a wide range of quantitative morphometric and compositional methods, particularly DW-MRI and ultrasound (US) imaging. Among the various functional imaging techniques, diffusion weighted imaging has the particular appeal that this method is widely available and completely non-invasive (without the injection of a contrast agent or a radioisotope).

This focused issue of Translational Imaging in Cancer Patient Care highlights current topics in the field of imaging addressing many common and debilitating oncological conditions. The authors have succeeded in covering a wide range of quantitative morphometric and compositional methods, particularly DW-MRI and ultrasound (US) imaging. Among the various functional imaging techniques, diffusion weighted imaging has the particular appeal that this method is widely available and completely non-invasive (without the injection of a contrast agent or a radioisotope).

Welcome to Pancreas 2018 Innovations in the Care of Pancreatic Cancer and Call for Papers

I am delighted welcome you to participate in Pancreas 2018, Innovations in the Care of Pancreatic Cancer. This international conference will take place at the Johns Hopkins Medical Campus Baltimore, Maryland, April 26-29, 2018.Pancreas 2018 follows on from the successful meetings in Glasgow (2016), Verona (2014) and Kyoto (2012) and is a major event in the calendar, providing a unique opportunity for all those working in the diagnosis and treatment of pancreatic cancer, to learn of the latest developments in this rapidly changing and expanding field.We hope you share our enthusiasm for the Conference and forward to seeing you in Baltimore in 2018.

This issue of Translational Cancer Research addresses the current state of knowledge regarding exosomes in body fluids and cancer. Exosomes are produced in increased numbers in cancer compared to normal cells. Exosomes are made by almost all cells, with the possible exception of red blood cells and are secreted into the tumor or normal cell adjacent body fluid. Cancer cell derived exosomes influence tumor growth, metastasis, evasion of the immune system and resistance to therapy.

This special issue will give the readers an insight on worldwide research on this topic. Different fields of interest are explored, describing the role of cancer stem cells, hypoxia, angiogenesis, immune system activation, DNA repair system, etc. in driving the biological effects induced by different types of treatment modalities and beams. Different experimental approaches are used, which cover the necessity of investigating basic medical physic and biological mechanisms, towards translational applications on preclinical and human models. The necessity to introduce biomarkers of normal tissues and tumor radiosensitivity into treatment planning is also discussed.

The current focused issue will be a stepping stone for many bladder cancer researchers to properly understand the latest trends in bladder cancer research and to lead to practical application in clinical practice. Finally, we would like to express our gratitude to renowned bladder cancer researchers from all over the world who participated in the development of this focused issue...

Vol 5, No 6 (Dec 2016) Focused Issue: p53 Biology and Cancer

In this volume, the reader can find papers describing mechanisms of post-transcriptional and post-translational control of p53 and its regulators MDM2 and MDMX, its interaction with other pathways, like the mTORC1 pathway, and its role not only in cancer but also in aging and inflammation...

Intra molecular interactions in the regulation of p53 pathway

Diagrams of MDM2 (A) and MDMX domains (B) and the intrinsically disordered regions identified by PONDR analysis (Predictors of Natural Disordered Regions). Short vertical lines indicate the location of phosphorylation sites and the corresponding kinases. Atomic structures for individual domains are shown under each diagram. The p53-binding domains of MDM2 and MDMX are shown as complexes with p53 N terminal peptide. The RING domains of MDM2 and MDMX are shown as part of a heterodimer.

Regulation of cytotoxic T-cell responses by p53 in cancer

Increasing evidence indicates that p53 also plays crucial roles in the regulation of immune responses, specifically in several aspects of the cytotoxic T-lymphocyte (CTL)-tumor cell interaction (5-8). Indeed, p53 responsive elements have been found in genes which impact the CTL response including the transporter associated with antigen processing 1 (TAP1) and endoplasmic reticulum amino peptidase 1 (ERAP1), through which p53 is directly involved in the upregulation of antigen presentation via the major histocompatibility complex (MHC) I pathway (5,7).

Linkage disequilibrium plots for the SNPs in the top eQTL list. (A) Four ROBO1 SNPs with significant ESR1-ROBO1 eQTL results; (B) three MMP16 SNPs with the significant MMP16-MMP16 eQTL results; (C) ten ROBO1 SNPs with the significant CSR1-ROBO1 eQTL results. The values in the triangles are r2. The strong LD is defined based on r2>0.8. SNP, single nucleotide polymorphism; eQTL, expression quantitative trait loci.

A systematic review and meta-analysis of the efficacy and safety of long-acting release somatostatin analogs in patients with advanced neuroendocrine neoplasms

Sugar intake from sugar-sweetened beverage among cancer and non-cancer individuals: the NHANES study

It has been estimated that there are approximately 14.5 million cancer survivors in the United States. One out of every six people over 65 is a cancer survivor. Recently growing evidence suggests a link between sugar-sweetened beverage (SSB) consumption and risk of pancreatic and endometrial cancer, and risk of colon cancer recurrence and mortality among cancer survivors. The objective of this study is to closely evaluate the impact of cancer status and other risk factors on sugar intake from SSBs.

Tanning bed use, risk of melanoma and opportunity for prevention with sulforaphane

The use of indoor tanning beds for cosmetic purposes has been very popular among the Caucasian population in the US. It is estimated that almost one in three Caucasian women aged 16 to 25 years use indoor tanning devices each year. Indoor tanning beds produce concentrated UV-A and UV-B rays and can be more harmful than the natural rays of the sun. The International Agency for Research on Cancer classified UV-emitting tanning devices as group 1 carcinogens in 2009. UV exposure from sunlight and indoor tanning bed has been linked to the risk of melanoma and non-melanoma skin cancers.

Studies have shown that there are many possible risk factors for cancer initiation or cancer prognosis. The complexity of cancer has led to the general recognition that identifying or targeting single risk factor is not sufficient for understanding cancer etiology or developing a comprehensive treatment strategy. Cancer may be influenced by a combination of genetic, lifestyle, social behavior, and environmental determinants of health. These risk factors may often coexist and interact with one another. Therefore, a better understanding of the genetic and social behavioral risk factors; such as tobacco use, unhealthy eating, physical inactivity and inherited genetic changes could contribute to improved strategies for primary, secondary, and tertiary cancer prevention and control.

Testimonials from prestigious Editorial Board Members

Prestigious editorial board members of Translational Cancer Research (TCR) recommend the journal according to their knowledge to TCR and their personal interaction with it. The editorial team appreciate supports from the Editorial Board Members.