A recently published study is presenting
some new research to confirm that e-cigarette vapour is safer than regular
cigarette smoke in a whole new way. The latest research was distributed in the
journal,
Drug and Alcohol Dependence and showed some interesting facts relating to how the body biologically
responds to e-cigarette vapour, with special attention to heart health.

The researchers’ data shows that, while
regular cigarette smoke has a significant effect on the cardiovascular
functions of the heart, the preliminary studies of e-cigarette vapor appears to
show little to no effect on a user’s immediate heart health. The researchers,
began their study knowing that e-cigarettes were safer than regular cigarette
smoke, but they just didn’t know by how much. As a result, they set out to
attempt to quantify e-cig’s relative harm. In response to the lack of
quantifiable knowledge, the researchers studied the biological response to the
e-cigarette aerosol and cigarette smoke at the cellular level. To accomplish
this, they exposed human coronary artery endothelial cells to extracts of both
e-cigarette vapor and cigarette smoke. They focused on any expression from the
cells that would be consistent with a stress response in the heart.

While cigarette smoke affected these cells
greatly, indicating stress on the cardiovascular system, e-cigarette aerosol
appeared to have no stressing effect on the cells and therefore would not cause
additional stress on the heart. In fact, if e-cigarettes replace cigarettes the
immediate stress on the heart not just diminishes, it disappears altogether.

This is encouraging news for vapers, who
have replaced the cigarettes in their lives with vaping. The study conclusion
states: “The use of e-cigarettes as a substitute for conventional cigarettes is
likely to reduce immediate tobacco-related harm, at least with respect to
cardiovascular harms.”

These results are promising, but the authors
of the study are clear that much more research needs to be done in order to
properly assess what the biological effects are of e-cigarette vapor. The
researchers explain the need for more robust and inclusive laboratory models
that can truly measure the effect, especially in comparison to regular
combustible tobacco.

The laboratory model is a big issue, as
there have been several studies that have come under fire for creating
conditions in the laboratory that simply do not mimic actual vaping. One of the
more notable examples is the continuing news headline that e-cigarette
contains formaldehyde, something that upon further inspection was
determined to only be a risk when the e-liquid was heated to a nearly
un-vapable level. The variables of battery strength, vaping temperature, and
e-liquid composition create a much larger framework for research than most
studies have ever had in place.

In addition, the authors also point out the
importance of studying the aerosol itself, rather than the composition of the
e-liquid, pointing out that if levels in the e-liquid are considered to be at a
“toxic” level, the vapor may not be.

The exciting thing about the result of this
study is that is one of the few that truly measure a biological response,
rather than just looking at what constituents exist in the vapor. Marcus Munafò, is
one of the authors of the study and be believes that, "research into these
biological effects is critical.” The biological
response gives us a far deeper look into what e-cigarette vapor can really do
to the human body, rather than just guessing.

The results of this study are, of course,
just preliminary but understanding the effects of e-cigarette aerosol,
especially in relation to cardiovascular health, is a big step in the right
direction for e-cigarette research. Addressing the laboratory model issues will
also encourage future studies to better create realistic laboratory examples,
and learn to include more variation to cover the full gamut of the e-cigarette
industry.

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