Skooma is valuable and often smuggled, being used as a form of currency amongst criminals. Unlike in Morrowind, where law-abiding shopkeepers do not touch it, merchants in Cyrodiil will buy and sell skooma freely.

Skooma never appears randomly, and most skooma does not respawn. Only the locked barrel outside Myvryna Arano's shack at the Waterfront has respawning skooma, which is then transported each week by Oghash gra-Magul to a hollowed-out rock by Walker Camp. Apart from this trade, the skooma vendors below have a respawning inventory.