SBP0254 - Prolactin Releasing Peptide-31 (PrRP-31), bovine

SBP0254 - Prolactin Releasing Peptide-31 (PrRP-31),
bovine
MW: 3576.5
H-Ser-Arg-Ala-His-Gln-His-Ser-Met-Glu-Ile-Arg-Thr-Pro-Asp-Ile-Asn-Pro-Ala-Trp-Tyr-Ala-Gly-Arg-Gly-Ile-Arg-Pro-Val-Gly-Arg-Phe-NH2
PrRP-31 and PrRP-20 are the first reported hypothalamic peptides that
exclusively stimulate the release of prolactin from the pituitary without
affecting that of other known hypophyseal hormones. Interestingly, the discovery
of these peptides is an example of an orphan peptide receptor being used to
identify its own ligand. Working backwards from the human orphan receptor, hGR3,
Hinuma et al. (1998) identified a peptide ligand in bovine hypothalamic
extracts. After isolation of the respective cDNA in bovine brain, they were able
to identify the 31-amino acid peptide (PrRP-31) and 20-amino acid fragment
(PrRP-20) corresponding to this sequence. The peptide sequences are reported to
be highly conserved in other species (human, rat). PrRP-31 has been shown to
stimulate prolactin release from a rat pituitary RC-4B/C adenoma cells, from
anterior pituitary cells from lactating rats, and from rat pituitary cells in a
perfusion assay.
Hinuma, S. et al. (1998) Nature 393, 272.
500µg
1mg