DepoDur(TM) is supplied in a 2 ml vial containing a 10 mg/ml suspension in sterile saline and is administered as a single dose epidural injection at the lumbar level prior to surgery (or after clamping of the umbilical cord during caesarean section).

A temperature probe was positioned on the skin of the thigh and skin temperature registered before epidural anaesthesia, every 10 minutes for the first hour after the epidural injection and every hour for the following four hours.

Since October 1995 Mr Ash, who lives at Ystrad Mynach near Caerphilly, has been attending the Pain Clinic in Cardiff, where about every six months he has been getting a pain-killing epidural injection.

In clinical practice, we and others (13-14) have observed that most patients indicate (on the first injection only) a sensation of 'cold' creeping along the back, near the epidural injection site, concurrent with the injection of local anaesthetic solution through the epidural catheter.

All of our patients are those giving insufficient response to conservative treatment, the same method was applied to all patients by the same doctor and the success rate of 62% is the one obtained following the one epidural injection (Figure 1a,b,c,d,e).

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