Clarke's Disease

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Clarke's Disease (also called Clarke's Syndrome) was a progressive, degenerative disorder of the Human brain. Symptoms included hallucinations and (in the terminal stage) severe pain. The disorder was ultimately fatal, and was incurable as of the 22nd century.

In the final draft script of "Borderland", Clarke's Disease was said to be "marked with bouts of extreme pain." In the final version of the episode, though, the notion that the pain came in the form of "bouts" was omitted.