He settled in the music scene of Sheffield, where he helped to build Fon Studios. Brydon made significant contributions producing Krush 1987 British pop hit "'s House Arrest". He continued his career with contributions to records and remixes such as "The Cowardly Worm" and the efforts of The Human League, Psychic TV, Boy George, Art of Noise and other groups. As a bassist and producer he was a member of Chakk and Cloud Nine.

His greatest contribution to the British pop art, to date, as a result of his meeting Róisín Murphy at a cocktail party, with whom he formed Moloko. The two fell off immediately and began working together for the first time as a two-disc duo, then bringing in a full line of tour and recording the last two albums of Moloko. Moloko was in indefinite hiatus, after the promotion of "statues" (2003), followed by a successful tour and the release of the video of the long-running concert "11,000 clicks" (2004), filmed in his last performance in Brixton, end of the "statues tour".

Prior to the bankruptcy of the legendary Fon Studios', Brydon had stripped his interests in him, so that he had done everything from the design of architectural studio to the equipment by hand selecting. He has followed a career side as a remixer, under the alias as DJ plankton.

During Moloko's hiatus, Brydon is focusing his energies on the design of a new studio.