Cadaver skin fills the gap in burn cases

Although synthetic skin has come on the market in the last 20 years, new products have not appeared as quickly as some experts had expected

?

At 5 o'clock one morning in late March, Linda Dixon stood in the stream of an open fire hydrant as emergency medical workers flushed her chest, arms and face with water.

Dixon, a 42-year-old home health aide in Queens, New York, said her estranged boyfriend, the father of her three children, had gone into her bedroom and thrown acid on her after a confrontation.

Dixon was taken to the NewYork-Presbyterian/Weill Cornell hospital, where she underwent two surgeries for the worst of her injuries, a third-degree burn across her chest. The surgical team's first priorities were to remove as much of the burned skin as possible (it can easily become infected) and to cover the wound temporarily with skin from a cadaver.

Cadaver skin is removed from donors shortly after their deaths, then processed and distributed by skin and tissue banks. It has long been the preferred option for a patient with the most severe burns until a graft of the patient's own skin can be applied. Although some synthetic skin has come on the market in the last 20 years, new products have not appeared as quickly as some experts expected.

And experts now realize that cadaver skin is unlikely to be replaced as a treatment option anytime soon.

"Cadaver skin still is probably the No. 1 substitute for the patient's own skin" in acute cases, said Roger Yurt, professor of surgery and director of the Hearst Burn Center. Yurt also oversees the hospital's dedicated skin bank, called the New York Firefighters Skin Bank.

Palmer Bessey, professor of surgery and associate director of the burn center, said cadaver skin was particularly valuable in cases like Dixon's, when the burn may penetrate deeper than is immediately apparent. Initially, it may not be clear whether the bed of the wound will be able to accept a graft, and under such circumstances, synthetics are more prone to infection than cadaver skin, Bessey said.

In Dixon's case, Bessey decided to use strips of cadaver skin, which had been frozen at the hospital's skin bank. In the operating room, these strips were thawed in a small tub of saline.

They were rolled through a meshing machine, which created a pattern of small holes, like the pattern in fishnet stockings. This allowed the cadaver skin to be stretched to cover a broader area of Dixon's chest. It also allowed for better drainage of the wound because blood clots or fluid could seep through the perforations and not get stuck under the graft.

Donated skin can help prevent infection, reduce pain and maintain body temperature. Patients with severe burns do not initially reject cadaver skin, because their immune systems are suppressed, Bessey said.

Each strip is about 0.33mm thick, roughly the thickness of sunburned skin. The strip includes the dull outer layer, or epidermis, and a small portion of the shiny inner layer, or dermis. Both are destroyed in a third-degree or full-thickness burn.

When a skin bank receives a call about a potential donor, an extensive screening process begins -- for risk factors associated with HIV, hepatitis, cancer, mad cow disease and even Chagas' disease, a parasitic infection.

"A large proportion of potential donors are rejected," said Nancy Gallo, the administrative director of the Firefighters Skin Bank and a registered nurse.

When donors are accepted and their families consent, a team from the skin bank goes to the hospital and surgically removes roughly 122 square centimeters of a cadaver's skin. The skin is taken to the skin bank, trimmed into bandage-like strips and cryogenically preserved. Cadaver skin can be stored in a freezer for up to five years, although it is invariably needed sooner.