The findings suggest that the oncogenic activity of hepsin (show HPN Antibodies) arises not only from elevated expression level but also from depletion of HAI-1, events which together trigger gain-of-function activity impacting HGF (show HGF Antibodies)/MET signalling and epithelial cohesion

the anti-migratory effects seen via gamma-catenin were driven by the expression of hepatocyte growth factor activator inhibitor Type I (HAI-1 or SPINT-1), an upstream inhibitor of the c-MET signaling pathway.

Data suggest HAI1 exhibits structural features consistent with classification in MANEC subclass of PAN (show SUPT6H Antibodies)/apple domain family with unifying features such as two additional disulfide bonds, two extended loop regions, and additional alpha-helical elements.

Matriptase (show ST14 Antibodies) activity was suppressed by the expression of HAI-1.

The results of the present study identified HAI-1 as a favorable prognostic marker for prostate cancer and may indicate that HAI-1 could be a therapeutic target for the treatment of this malignancy.

HAI-1 expression correlates with the differentiation status of colorectal epithelia and could serve as a differentiation marker.

HAI-1 and HAI-2 influence proliferation and cell fate of NPCs and their expression levels are linked to BMP sign

HAI-1 has a crucial suppressive role in oral squamous cell carcinoma cells' invasiveness.

HAI-1 and -2 are overexpressed in the liver in cholangiopathies with ductular reactions and are possibly involved in liver fibrosis and hepatic differentiation.

HAI-1/SPINT1 plays an important role in maintaining colonic epithelium integrity.

HAI-1 is required for branching morphogenesis in the chorioallantoic placenta.

Hepatocyte growth factor activator inhibitor-1 (HAI-1) is essential for the integrity of basement membranes in the developing placental labyrinth.

serine Peptidase Inhibitor, Kunitz Type 1 (SPINT1) Antigen Profile

Protein Summary

The protein encoded by this gene is a member of the Kunitz family of serine protease inhibitors. The protein is a potent inhibitor specific for HGF activator and is thought to be involved in the regulation of the proteolytic activation of HGF in injured tissues. Alternative splicing results in multiple variants encoding different isoforms.