The Analytical Microscopy Laboratory is located on the 6th Floor of the Caspary Research Building. The services offered are:

Methacrylate embedding and sectioning of calcified tissues.

Paraffin embedding and sectioning of soft tissues or decalcified tissues.

Immunocytochemistry for localization of specific proteins in cells and extracellular matrix.

Frozen sections of calcified and decalcified tissues.

Morphometric measurements of histologic structures and cellular content in order to provide quantitative analysis of tissue activities.

These services are utilized by the research and clinical staff of Hospital for Special Surgery on a "fee-for service" basis. The laboratory also provides services to users outside of HSS. Please see the fee schedule.

The laboratory has resources which have made it unique among core facilities in the New York area.

Immunocytochemistry is in great demand now that so many primary antibodies are available. We routinely apply immunostaining to rat, mouse, rabbit and human samples. In addition, if immunostaining is coupled with morphometry, we can begin to quantitate tissue and cellular activities.

We are unique in that we can provide total histological service for most calcified tissues, especially bone and cartilage. For example, sections of calcified bone embedded in methacrylate can be sectioned down to 3-5 microns thickness which can be used for morphometry or other analytical techniques. There are few laboratories in the US which can offer similar services.