Degenerative exhaustion condition

My life story:
- had bad migraines as a teen, but that's it. Healthy kid.
- at 19 years old moved to Canada: started smoking pot every day, terrible diet and a nose piercing (skin got infected for months). Fatigue condition started 6 months after this episode, felt like huge jetlag and never looked back, only got worse over time progressively.

I'm sorry to hear that you are experiencing all these horrible symptoms.
There is a lot of information here that could be of help to you.

I have not had the opportunity to try many pharmaceutical treatments but have found some improvement with supplements and some other simple treatments.

The first recommendation is always rest. Don't overexert.
I have found that Vitamin D3 helped my brain fog which has become quite severe. If you moved to Canada that could be an issue.
I also changed my diet. This is a complicated issue and there are many threads that discuss various diets. Everyone is different and responds to different dietary changes.

Also, if there are endocrine issues you might want to consider trying an electrolyte solution.

You might also want to check out the Methylation Protocol threads. That can be complicated too but there are plenty of people here who will help you if you need it.