Jianyong Chen, Ph.D.
Research Assistant Professor

Biography

I was trained as an organic chemist and in medicinal chemistry. My major research interest is the design, synthesis, discovery and development of novel small-molecule inhibitors for the treatment of human cancer and other diseases. I have been working in Professor Shaomeng Wang’s laboratory in the Molecular Therapeutics Program at the University of Michigan Comprehensive Cancer Center since 2001. Through my research, I have collaborated extensively with computational chemists, biochemists, structural biologists, cell biologists and pharmacologists and have accumulated extensive research expertise in the design and discovery of novel small-molecule drugs. One of my small-molecule inhibitors I have discovered at the University of Michigan is now in Phase II clinical trials for the treatment of human cancer and additional compounds are in advanced preclinical development. I have served as co-investigators on several NIH R01 grants.

Research Interests

Design, synthesis and biological evaluation of dopamine 3 agonists, partial agonists, and antagonists for the treatment of a variety of conditions, including drug abuse, restless legs syndrome, schizophrenia, and Parkinson’s disease.

Design, synthesis and biological evaluation of STAT3 inhibitors for the treatment of cancers.

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