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We want control if mitochondrial respiration is reduced in patients with heart failure compared to non-heart failure, and if the ischemic period during surgery reduces respiration. Another aspect is to reveal if exercise training and remote ischemic preconditioning give protection to the heart during surgery. For patients with a transplanted heart it is a goal to investigate whether exercise training improves myocardial mitochondrial respiration.

Study of Gaining Further Understanding of the Underlying Mechanisms of Myocardial Function

Brief Summary

The main focus of the project is to determine to what degree myocardial energy metabolism is linked to impaired function in human cardiomyocytes, whether exercise training and remote ischemic preconditioning can restore cardiomyocyte function and whether this is linked to improved mitochondrial and cell function.