Mouse (Murine) Legumain (LGMN) Interaktionspartner

This study showed that legumain may serve as a biomarker of disease, and that the occurrence of legumain-expressing macrophages in regions of acinar-to-ductal metaplasia suggests that this protease may influence reprogramming events that lead to inflammation-induced pancreatic cancer.

AEP is required for normal protein catabolism by PTCs, and its loss induces proliferative and other abnormalities in the murine kidney, at least in part through defective regulation of the EGF receptor (zeige EGFR ELISA Kits)

Cow (Bovine) Legumain (LGMN) Interaktionspartner

legumain and TIMP-2 (zeige TIMP2 ELISA Kits) mRNAs were up-regulated in the endometrium during the luteal phase of the oestrous cycle and during early pregnancy

Arabidopsis thaliana Legumain (LGMN) Interaktionspartner

at the early stage of seed development, deltaVPE is involved in cell death of limited cell layers, the purpose of which is to form a seed coat

Pig (Porcine) Legumain (LGMN) Interaktionspartner

The LGMN and CST6 (zeige CST6 ELISA Kits) system at the maternal-fetal interface may play an important role in the establishment and maintenance of pregnancy in pigs.

Legumain (LGMN) Antigen-Profil

Beschreibung des Gens

This gene encodes a cysteine protease that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types. This gene has a pseudogene on chromosome 13. Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined. These two variants encode the same isoform.