She grew up and lived most of her life in the family home on South Pearl Street. She apparently did not marry. She was a longtime member of St. Peter's Anglican Church. She sponsored a number of baptisms there during the 1750s and 60s.

In 1753, she was willed a share of Isaac Fryer's estate, left his "great cupboard or kas," and allowed to live in the family home until she married.

Her father died in 1755. By 1767, she was named on city assessment rolls in the first ward house headed by her mother. Over the next two decades, she would be listed on tax rolls but it is not clear whether she was living separately or with the family of her brother.

Catherine Fryer died in October 1791 at age sixty. She was buried from the Albany Dutch church. Letters of administration were issued on her estate to her brother, Isaac, in August 1792.