1530s (earlier lepruse, mid-15c.), from leprous; see leper. First used in Coverdale Bible, where it renders Hebrew cara'ath, which apparently was a comprehensive term for skin diseases. Because of pejorative associations, the use of the word in medical context has been banned by the World Health Organization and replaced by Hansen's disease, named for Norwegian physician Armauer Hansen (1841-1912) who in 1871 discovered the bacillus that causes it.