Form 8.3 - TAKEDA PHARMACEUTICAL CO LTD

A PERSON WITH INTERESTS IN RELEVANT SECURITIES REPRESENTING 1% OR MORE

Rule 8.3 of the Takeover Code (the “Code”)

1. KEY INFORMATION

(a)

Full name of discloser:

Barclays PLC.

(b)

Owner or controller of interest and short

positions disclosed, if different from 1(a):

(c)

Name of offeror/offeree in relation to whose

TAKEDA PHARMACEUTICAL CO LTD

relevant securities this form relates:

(d)

If an exempt fund manager connected with an

offeror/offeree, state this and specify identity of

offeror/offeree:

(e)

Date position held/dealing undertaken:

06 April 2018

(f)

In addition to the company in 1(c) above, is the discloser making

YES:

disclosures in respect of any other party to the offer?

SHIRE PLC

2. POSITIONS OF THE PERSON MAKING THE DISCLOSURE

If there are positions or rights to subscribe to disclose in more
than one class of relevant securities of the offeror or offeree named in
1(c), copy table 2(a) or (b) (as appropriate) for each additional class
of relevant security.

(a) Interests and short positions in the relevant securities of the
offeror or offeree to which the disclosure relates following the dealing
(if any)

Class of relevant security:

ORD

Interests

Short Positions

Number

(%)

Number

(%)

(1)

Relevant securities owned

and/or controlled:

13,961,749

1.76%

13,697,707

1.72%

(2)

Cash-settled derivatives:

13,382,193

1.68%

13,410,400

1.69%

(3)

Stock-settled derivatives (including options)

and agreements to purchase/sell:

13,357,000

1.68%

13,777,000

1.73%

(4)

TOTAL:

40,700,942

5.12%

40,885,107

5.14%

All interests and all short positions should be disclosed.

Details of any open stock-settled derivative positions (including
traded options), or agreements to purchase or sell relevant securities,
should be given on a Supplemental Form 8 (Open Positions).

(b) Rights to subscribe for new securities (including directors’ and
other employee options)

Class of relevant security in relation to which subscription right
exists:

Details, including nature of the rights concerned and relevant
percentages:

3. DEALINGS (IF ANY) BY THE PERSON MAKING THE DISCLOSURE

Where there have been dealings in more than one class of relevant
securities of the offeror or offeree named in 1(c), copy table 3(a),
(b), (c) or (d) (as appropriate) for each additional class of relevant
security dealt in.

The currency of all prices and other monetary amounts should be
stated.

(a) Purchases and sales

Class of relevant

Purchase/sale

Number of

Price per unit

security

securities

ORD

Purchase

100

5,000.0000 JPY

ORD

Purchase

200

5,079.0000 JPY

ORD

Purchase

500

4,998.3000 JPY

ORD

Purchase

1,000

5,092.5000 JPY

ORD

Purchase

1,800

5,002.6666 JPY

ORD

Purchase

3,000

5,069.4333 JPY

ORD

Purchase

3,200

5,082.2812 JPY

ORD

Purchase

3,300

5,002.0606 JPY

ORD

Purchase

4,700

5,179.7234 JPY

ORD

Purchase

5,200

5,065.2115 JPY

ORD

Purchase

5,900

5,001.2711 JPY

ORD

Purchase

6,100

5,002.6065 JPY

ORD

Purchase

6,400

5,034.1718 JPY

ORD

Purchase

13,700

5,125.0292 JPY

ORD

Purchase

14,700

5,245.0000 JPY

ORD

Purchase

16,600

5,232.1265 JPY

ORD

Purchase

84,200

5,059.0510 JPY

ORD

Purchase

169,800

5,058.8651 JPY

ORD

Purchase

224,900

5,085.1378 JPY

ORD

Purchase

395,900

5,074.4675 JPY

ORD

Sale

100

5,080.0000 JPY

ORD

Sale

500

4,998.3000 JPY

ORD

Sale

500

5,097.2000 JPY

ORD

Sale

700

5,005.0000 JPY

ORD

Sale

900

5,002.0000 JPY

ORD

Sale

900

5,112.7777 JPY

ORD

Sale

1,200

5,000.6666 JPY

ORD

Sale

1,600

5,000.0000 JPY

ORD

Sale

2,000

5,018.0000 JPY

ORD

Sale

2,500

5,060.4400 JPY

ORD

Sale

3,300

5,065.1212 JPY

ORD

Sale

4,700

5,179.1914 JPY

ORD

Sale

6,400

5,034.1718 JPY

ORD

Sale

8,000

5,082.4750 JPY

ORD

Sale

13,800

5,002.0434 JPY

ORD

Sale

18,100

5,075.9723 JPY

ORD

Sale

21,300

5,042.9906 JPY

ORD

Sale

224,900

5,084.0062 JPY

ORD

Sale

574,800

5,081.8235 JPY

(b) Cash-settled derivative transactions

Class of relevant security

Product description

e.g. CFD

Nature of dealing

e.g. opening/closing a long/short position, increasing/reducing
a long/short position

Number of reference securities

Price per unit

(c) Stock-settled derivative transactions (including options)

(i) Writing, selling, purchasing or varying

Class of relevant security

Product description e.g. call option

Writing, purchasing, selling, varying etc.

Number of securities to which option relates

Exercise price per unit

Type

e.g. American, European etc.

Expiry date

Option money paid/ received per unit

(ii) Exercise

Class of relevant security

Product description

e.g. call option

Exercising/ exercised against

Number of securities

Exercise price per unit

(d) Other dealings (including subscribing for new securities)

Class of relevant security

Nature of dealing

e.g. subscription, conversion

Details

Price per unit (if applicable)

4. OTHER INFORMATION

(a) Indemnity and other dealing arrangements

Details of any indemnity or option arrangement, or any agreement or
understanding, formal or informal, relating to relevant securities
which may be an inducement to deal or refrain from dealing entered
into by the person making the disclosure and any party to the offer
or any person acting in concert with a party to the offer:

Irrevocable commitments and letters of intent should not be
included. If there are no such agreements, arrangements or
understandings, state “none”

None

(b) Agreements, arrangements or understandings relating to options or
derivatives

Details of any agreement, arrangement or understanding, formal or
informal, between the person making the disclosure and any other
person relating to:

(i) the voting rights of any relevant securities under any option;
or

(ii) the voting rights or future acquisition or disposal of any
relevant securities to which any derivative is referenced:

If there are no such agreements, arrangements or
understandings, state “none”

None

(c) Attachments

Is a Supplemental Form 8 (Open Positions) attached?

YES

Date of disclosure:

9 Apr 2018

Contact name:

ELISE TANG

Telephone number:

0207 1163001

Public disclosures under Rule 8 of the Code must be made to a
Regulatory Information Service.

The Panel’s Market Surveillance Unit is available for consultation in
relation to the Code’s disclosure requirements on +44 (0)20 7638 0129.