Uptake, a predictive analytics startup that helps companies in industries like construction and rail operate more efficiently by using data to predict when their machines will fail, was launched in 2014 by Groupon co-founder Brad Keywell. The startup has raised more than $140 million and is valued at over $2 billion.

The startup keeps its customers close to the vest, having only publicly announced two: Caterpillar and Warren Buffett’s Berkshire Hathaway Energy. Uptake helps Caterpillar with predictive machine maintenance, and offers similar services to Berkshire subsidiaries MidAmerican Energy Company and BHE Renewables.

CNBC’s Disruptor 50, now in its 5th year, was crafted based on quantitative and qualitative metrics including VC funding and “off-the-record information on sales and user growth.”

“Uptake is leading a new category of enterprise software by delivering industry-specific predictive insights – resulting in increased uptime, improved productivity and enhanced safety – leveraging a common platform,” Keywell said in a statement. “We sell outcomes, and we do it with a speed rarely seen in the world of software.”

Jim Dallke is the associate editor of Chicago Inno. As part of the team that launched Chicago Inno in 2014, Jim covers the ins and outs of Chicago’s tech and innovation scene, and is always looking for scoops and story ideas. Get in touch: Jdallke@americaninno.com.