Resumen

Tephrosia purpurea L. (Leguminosae), commonly known as Unhali in Marathi is a copiously
branched perennial herb. Traditionally the roots of this plant are used in the treatment of ulcer and colic
pain. So the present work was undertaken to validate its use in the treatment of ulcerative colitis by using
suitable scientific methods. Shade dried and coarsely powdered roots were subjected to successive extraction
with ethanol and water. The dried extracts (100 and 200 mg/kg) were screened for ulcerative colitis
using the method acetic acid induced ulcerative colitis in mice. Macroscopical study of the colon, level of
myeloperoxidase in colon and histopathology of the colon tissue were studied for the assessment of the activity.
Results showed that aqueous extract was significantly effective in the treatment of ulcerative colitis
at dose of 200 mg/kg. It can be concluded that the polar constituents of T. purpurea L. may be useful in the
treatment of ulcerative colitis.

Información general

Fecha de publicación:2011

Idioma del documento:Inglés

Revista:Latin American Journal of Pharmacy; vol. 30, no. 2

Institución de origen:Colegio de Farmacéuticos de la Provincia de Buenos Aires