rmM-CSF

Granulocyte/Macrophage Colony-Stimulating Factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. CSF-1 induces cells of the monocyte/macrophage lineage. It plays a role in immunological defenses, bone metabolism, lipoproteins clearance, fertility and pregnancy. Rec. mouse Macrophage Colony Stimulating Factor produced in E.coli is a disulfide linked homodimer, non-glycosylated, polypeptide chain of 2 x 156 amino acids and a total molecular mass of 36.4 KD. Synonyms: CSF-1, Lanimostim, MCSF, M-CSF.

Technical Data: Assay: >98% (by SDS and HPLC); sequence of the first five N-terminal amino acids of MCSF: Met-Lys-Glu-Val-Ser; Biological activity: The ED50, calculated by the dose-dependent stimulation of the proliferation of murine M-NFS-60 indicator cells was found 0.91ng/mL corresponding to 1,098,901 U/mg.