A study of hantavirus

Sequence of the amplified RNA indicated that the mouse was infected with Monongahela hantavirus identical to virus identified in rodents collected from the location where patient B was presumed to have been infected.

Her research interests are the diagnosis and pathophysiology of arboviruses, with special interest in hantavirus circulation in French Guiana. Rapidly progressive acute pulmonary edema developed in 15 of the 17 patients 88 percentand 13 patients, all of whom had profound hypotension, died case fatality rate, 76 percent.

Surveillance was initiated for an influenza-like illness followed by the rapid onset of unexplained respiratory failure. First, however, we introduce the basic biology of the virus.

The estimated sample size to document the overall prevalence in the total population was approximately persons. A repeat CBC revealed bands granulocytes: The positive criteria were similar to those described by MacNeil et al.

Twelve patients 67 percent resided in New Mexico, five 28 percent in Arizona, and one 6 percent in Colorado. The first HPS cases in Jujuy Province were confirmed inand since then, their number has been progressively increasing. He became progressively hypoxic, requiring supplemental oxygen, bilevel positive airway pressure, and eventually intubation with mechanical ventilation.

Although the diagnosis at the time of admission was pneumonia in 7 patients 41 percent10 patients 59 percent had other diagnoses: According to interviews with his coworkers, the patient had spent the previous month trapping small mammals for study and handling mice Peromyscus spp.

Three HPS-endemic areas have been recognized in Argentina: Repeated radiographs revealed bilateral pulmonary edema. The physical examination was normal.

In addition, persons who have occupational exposure to rodents and their excreta should be trained in proper animal handling and use of personal protective equipment. The National Academies Press.

In all, rodents were trapped by the investigating team during August from three rural sites in Randolph County: Subsequently, metamyelocytes were noted in 11 of 16 patients 69 percentand atypical lymphocytes in 6 of 16 38 percent. Increases in the hematocrit and partial-thromboplastin time were predictive of death.

Am J Trop Med Hyg.

In Asia hantaviruses are associated with hemorrhagic fever and renal disease. Clinical manifestations of New World hantaviruses. Two patients 12 percent were cigarette smokers, and one had a history of excessive alcohol use. In early July, a Randolph County resident, a man aged 41 years, spent a weekend at a log cabin with his family.

Cases have been reported in 36 states. A spleen biopsy was also positive by immunohistochemistry for hantavirus antigens. References Hantavirus pulmonary syndrome.We initiated a study to elucidate the ecology and epidemiology of hantavirus infections in northern Argentina.

Two Cases of Hantavirus Pulmonary Syndrome Randolph County, West Virginia, July Hantavirus pulmonary syndrome (HPS) is a rare cardiopulmonary disease caused by viruses of the genus Hantavirus, for which rodents are the natural reservoir (1,2). Learn hantavirus with free interactive flashcards.

Choose from different sets of hantavirus flashcards on Quizlet. Hantavirus-infected deer mice (Peromyscus maniculatus) can excrete the virus in their urine, saliva, and droppings. Infected deer mice live throughout the state and people are.

A previous study reported that the presence of hantavirus IgG during the first week of infection might be a predictor of survival, but we found no evidence supporting this view.

To determine the viral RNA load in each serum sample, we performed real-time PCR.