A smirking O.J. Simpson was handcuffed and hauled off to jail last night to face multiple felony charges for allegedly busting into a Vegas hotel room with five other men and snagging sports memorabilia he claims belonged to him.

Simpson, 60, wearing a golf shirt and jeans, his hands cuffed, was put in a Mitsubishi SUV with tinted windows for the drive from a police station to the Clark County Detention Center.

The disgraced football great was busted a day after the arrest of golfing buddy Walter Alexander, 46, of Mesa, Ariz., who police say was armed when he accompanied Simpson in the Thursday-night holdup.

Simpson was booked on two counts of robbery with a deadly weapon, two counts of assault with a deadly weapon, conspiracy to commit burglary and burglary with a firearm. The district attorney, meanwhile, said he expected Simpson to ultimately be charged with seven felonies and one gross misdemeanor.

“He’s facing a lot of time,” said DA David Roger, noting the top charge alone carries a sentence of up to 35 years in prison.

Simpson was being held without bail.

He is accused of busting into a room at the Palace Station hotel at around 7:15 p.m. on Thursday with his five alleged accomplices and taking items of sports memorabilia and cellphones from the men inside.

He was named a suspect the next day and finally arrested yesterday after cops searched two area homes and found two guns they believe were used that night.

Simpson was picked up at around 11 a.m. in his room at the Palms Hotel, where security guards and cops whisked him out a side door.

He is likely to be arraigned today, and a preliminary hearing has been scheduled for tomorrow.

“We believe it is an extremely defensible case based on conflicting witness statements, flip-flopping by witnesses and witnesses making deals with the government to flip,” he said.

Information from Alexander, who was released without bail, led to Simpson’s arrest, cops said.

Alexander’s lawyer, Robert Rentzer, said his client “cooperated with police with the understanding that nothing he said would be used against him.”

Police are seeking four other suspects: Thomas Scotto, 45, of Miami, Clarence Stewart, 53, of Las Vegas, Michael McClinton, 49, also of Vegas, and an unidentified person.

Simpson’s latest legal fiasco began as a plan to recover what he called “stolen” memorabilia, including the suit he wore when he was found not guilty of murder, numerous photos – one with late FBI chief J. Edgar Hoover – and signed items.

In what Simpson described as a “sting operation,” he recruited the other men Thursday night at a Palms Hotel cocktail party ahead of Scotto’s Saturday-night wedding.

He said he didn’t seek cops’ help because they haven’t been responsive to his needs since the 1994 slayings of his ex-wife Nicole Brown Simpson and her pal Ron Goldman. “The police, since my trouble, have not worked out for me,” he said.

There have been conflicting accounts about what transpired in the room, where memorabilia collectors Alfred Beardsley, Thomas Riccio and Bruce Fromong – all O.J. associates – were meeting to discuss the sale of Simpson-related merchandise.

In a 6-minute audio tape recorded by Riccio, Simpson is heard several times shouting, “You think you can steal my s- – – and sell it?” according to TMZ.com.

“These guys came in military style,” Beardsley told The Post yesterday. “I felt they were either FBI or law enforcement.”

Police did not charge Simpson with having a gun in the incident.

Beardsley, a longtime Simpson business associate, said one of the men yelled, “Police!”

“I was shoved and frisked,” he said.

Fromong told The Post his cellphone was taken because Simpson was looking for a phone number.

Beardsley has said he and Simpson have since made up, but he has agreed to cooperate with investigators.

“I am not going to disrespect an extensive investigation,” he said. “They know better than I. It’s a big mess.”