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Unknown Spyware/malware....?

Hey, got this virus, no idea what it is called. Tried removing it the standard ways, but without knowing what it is, it's a little hard.

Have run Trend micro house call and McAfee stinger, along with spybot. Which removed some problems, but not the main one.The virus is causing a pop up to occur randomly, also when using My Documents/My Computer. It has also hijacked IE.

The message that pops up is; Attention, *****! Some dangerous viruses detected in your system. Microsoft Windows XP files corrupted. This may lead to the destruction of important files in C.\Windows. Download protection software now! Click OK to download the antispyware (Recommended).

There is no OK button, only yes or no. No matter which is pressed it takes it to a hijacked website.