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SPLUNC1 is an endogenous inhibitor of the epithelial sodium channel (ENaC) which is responsible for Na⁺ and fluid absorption across colon, kidney, and airway epithelia. The partial sequence GGLPVPLDQTLPLNVNPA (SPLUNC1 22-39) corresponds to the ENaC inhibitory domain of SPLUNC1. As ENaC hyperactivity contributes to the development of cystic fibrosis in the lungs, the fragment could help to develop new strategies for the treatment of this genetic disorder.