To start a new thread for this (since there are four pages on the other big thread), the long awaited Instant Client 11.2 for OS X is available: https://blogs.oracle.com/opal/entry/os_x_users_11gr2_oracle

I've tried to use it to compile PHP with instantclient 11R2 (64bit) and run as an apache module in a webserver (just as I've done many times before on another mac still running OSX 10.6 and using the Oracle 10R2 64-bit instantclient). My Instantclient directory has the basic file + sqlplus + SDK

It seems to compile and install OK, But when I to start the apache webserver I get this error :

Outstanding, thanks Christopher and Oracle folks! I can now connect to Oracle via 64-bit python and the cx_Oracle module on os/x 10.8. (I haven't tried to run the "insert into select" statement below, but I'm willing to try to replicate if someone can produce a test case.)