Inheritance

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How is hereditary diffuse leukoencephalopathy with spheroids (HDLS) inherited?

HDLS is inherited in an autosomal dominant pattern, which means one copy of the altered gene in each cell is sufficient to cause the disorder. In most cases, an affected person inherits the mutation from one affected parent. Other cases result from new mutations in the gene and occur in people with no history of the disorder in their family.[1]