A few days ago, a Master of Arts, who is still a young man, and therefore the recipient of a modern education, stated to me that until he had reached the age of twenty he had never been taught anything whatever regarding natural phenomena, or natural law. Twelve years of his life previously had been spent exclusively amongst the ancients. The case, I regret to say, is typical. Now we cannot, without prejudice to humanity, separate the present from the past.

'On the Study of Physics', From a Lecture delivered in the Royal Institution of Great Britain in the Spring of 1854. Fragments of Science for Unscientific People: A Series of Detached Essays, Lectures, and Reviews (1892), Vol. 1, 284-5.

All government, in its essence, is organized exploitation, and in virtually all its existing forms it is the implacable enemy of every industrious and well-disposed man ... The typical politician is not only a rascal but also a jackass, so he greatly values the puerile notoriety and adulation that sensible men try to avoid.

But it is precisely mathematics, and the pure science generally, from which the general educated public and independent students have been debarred, and into which they have only rarely attained more than a very meagre insight. The reason of this is twofold. In the first place, the ascendant and consecutive character of mathematical knowledge renders its results absolutely insusceptible of presentation to persons who are unacquainted with what has gone before, and so necessitates on the part of its devotees a thorough and patient exploration of the field from the very beginning, as distinguished from those sciences which may, so to speak, be begun at the end, and which are consequently cultivated with the greatest zeal. The second reason is that, partly through the exigencies of academic instruction, but mainly through the martinet traditions of antiquity and the influence of mediaeval logic-mongers, the great bulk of the elementary text-books of mathematics have unconsciously assumed a very repellant form,—something similar to what is termed in the theory of protective mimicry in biology “the terrifying form.” And it is mainly to this formidableness and touch-me-not character of exterior, concealing withal a harmless body, that the undue neglect of typical mathematical studies is to be attributed.

I definitely deny that any pathological process, i.e. any life-process taking place under unfavourable circumstances, is able to call forth qualitatively new formations lying beyond the customary range of forms characteristic of the species. All pathological formations are either degenerations, transformations, or repetitions of typical physiological structures.

I will ask you to mark again that rather typical feature of the development of our subject; how so much progress depends on the interplay of techniques, discoveries and new ideas, probably in that order of decreasing importance.

This is the original quote, which gave rise to the commonly seen misstated shortened quote as: “Progress in science depends on new techniques, new discoveries and new ideas, probably in that order”—with the qualifying words “interplay” and “decreasing importance” omitted. From Brenner’s own handwritten notes of a Speech (20 Mar 1980), 'Biology in the 1980s', at the Friedrich Miescher Institute in Basel, Switzerland. Reproduced in his article 'Life sentences: Detective Rummage investigates', The Scientist (19 Aug 2002), 16, No. 16, 15. He reflects on the original wording of the quote, from his notes that he “came across”, while rummaging through “the piles of papers that I have accumulated,” (hence “Detective Rummage” in the title). See more on the commonly seen misstated shortened quote also on the Sydney Brenner Quotes web page of this site, beginning, “Progress in science…”.

It seems to me that the evidence ... is opposed to the view that the spirals are individual galaxies comparable with our own. In fact, there appears as yet no reason for modifying the tentative hypothesis that the spirals are not composed of typical stars at all, but are truly nebulous objects.[Contradicting the view of Heber Curtis during the Shapley-Curtis debate on 26 Apr 1920 to the National Academy of Sciences.]

Sir Hiram Maxim is a genuine and typical example of the man of science, romantic, excitable, full of real but somewhat obvious poetry, a little hazy in logic and philosophy, but full of hearty enthusiasm and an honorable simplicity. He is, as he expresses it, “an old and trained engineer,” and is like all of the old and trained engineers I have happened to come across, a man who indemnifies himself for the superhuman or inhuman concentration required for physical science by a vague and dangerous romanticism about everything else.

The maintenance of biological diversity requires special measures that extend far beyond the establishment of nature reserves. Several reasons for this stand out. Existing reserves have been selected according to a number of criteria, including the desire to protect nature, scenery, and watersheds, and to promote cultural values and recreational opportunities. The actual requirements of individual species, populations, and communities have seldom been known, nor has the available information always been employed in site selection and planning for nature reserves. The use of lands surrounding nature reserves has typically been inimical to conservation, since it has usually involved heavy use of pesticides, industrial development, and the presence of human settlements in which fire, hunting, and firewood gathering feature as elements of the local economy.

The propositions of mathematics have, therefore, the same unquestionable certainty which is typical of such propositions as “All bachelors are unmarried,” but they also share the complete lack of empirical content which is associated with that certainty: The propositions of mathematics are devoid of all factual content; they convey no information whatever on any empirical subject matter.

The theory here developed is that mega-evolution normally occurs among small populations that become preadaptive and evolve continuously (without saltation, but at exceptionally rapid rates) to radically different ecological positions. The typical pattern involved is probably this: A large population is fragmented into numerous small isolated lines of descent. Within these, inadaptive differentiation and random fixation of mutations occur. Among many such inadaptive lines one or a few are preadaptive, i.e., some of their characters tend to fit them for available ecological stations quite different from those occupied by their immediate ancestors. Such groups are subjected to strong selection pressure and evolve rapidly in the further direction of adaptation to the new status. The very few lines that successfully achieve this perfected adaptation then become abundant and expand widely, at the same time becoming differentiated and specialized on lower levels within the broad new ecological zone.

Typical of the fundamental scientific problems whose solution should lead to important industrial consequences are, for example, the release of atomic energy, which experiment has shown to exist in quantities millions of times greater than is liberated by combustion.

An early speculation on using the amount of energy that could be released from uranium atoms. In a letter to Henry Ford (18 May 1931). He recorded earlier thoughts on the subject in his Research Notebook, entry for 23 Jul 1930, in Arthur H. Compton Notebooks, Washington University, St. Louis, and AIP. Cited by Stanley Coben, in 'The Scientific Establishment and the Transmission of Quantum Mechanics to the United States, 1919-32', The American Historical Review (Apr 1971), 76, No. 2, 466.

In science it often happens that scientists say, 'You know that's a really good argument; my position is mistaken,' and then they would actually change their minds and you never hear that old view from them again. They really do it. It doesn't happen as often as it should, because scientists are human and change is sometimes painful. But it happens every day. I cannot recall the last time something like that happened in politics or religion.
(1987) -- Carl Sagan