Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))* All genome coordinats were lifted-over on hg19.* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Endoplasmic reticulum chaperone that plays a key role inprotein folding and quality control in the endoplasmic reticulumlumen (PubMed:2294010, PubMed:23769672, PubMed:23990668,PubMed:28332555). Involved in the correct folding of proteins anddegradation of misfolded proteins via its interaction withDNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5from its substrate (By similarity). Acts as a key repressor of theERN1/IRE1-mediated unfolded protein response (UPR)(PubMed:1550958, PubMed:19538957). In the unstressed endoplasmicreticulum, recruited by DNAJB9/ERdj4 to the luminal region ofERN1/IRE1, leading to disrupt the dimerization of ERN1/IRE1,thereby inactivating ERN1/IRE1 (By similarity). Accumulation ofmisfolded protein in the endoplasmic reticulum causes release ofHSPA5/BiP from ERN1/IRE1, allowing homodimerization and subsequentactivation of ERN1/IRE1 (By similarity).{ECO:0000250|UniProtKB:G3I8R9, ECO:0000250|UniProtKB:P20029,ECO:0000269|PubMed:1550958, ECO:0000269|PubMed:19538957,ECO:0000269|PubMed:2294010, ECO:0000269|PubMed:23769672,ECO:0000269|PubMed:23990668, ECO:0000269|PubMed:28332555}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at