Originally there was only one moonstone but Karla Sofen got a second moonstone from her's predecessor Lloyd Bloch's Counter Earth counterpart Phantom Eagle after he went insane. Counter Earth and it's inhabitants were created by Franklin Richards. Having two gems greatly amplified Karla Sofen's power. When she was put into a coma Helmut Zemo seizes the stones. Some time later one of the stones was destroyed by Songbird which resulted in Helmut Zemo being hurled backwards in time to relive his family's history.

The Moonstone was once a part of a larger whole called the Lifestone Tree. The Lifestone Tree was an ancient collaborative effort by various alien races to create a team of champions to safeguard the galaxy. The tree was composed of relics various alien cultures had accumulated and were believed to be remnants from the Big Bang.[1] The team was named the Choses Eight of Fate. Ajes'ha a Kree warrior that was a member of the group possessed the moonstone and her memories are archived within the stone. Karla Sofen eventually began unwittingly tapping into those memories after she fell for Hawkeye which drove her somewhat insane until ISAAC the supercomputer of the Titanian Eternals cured her.