The Permeability of Boronophenylalanine

Summary

The integrity of the blood-brain barrier may severely restrict the passage of drugs intended for cells within the central nervous system. These experiments were designed to show whether one particular drug used for the treatment of gliomas, boronophenylalanine (BPA), is affected by the state of the BBB.

The results show that the degree of BBB disruption does not influence the amount of BPA accumulating in normal brain tissue.