On Wednesday, the day before her appearance on Jimmy Kimmel Live, Oprah announced her endorsement of Hillary Clinton for president.

"Regardless of your politics, it's a seminal moment for women," Oprah told Entertainment Tonight. "What this says is, there is no ceiling, that ceiling just went boom! It says anything is possible when you can be leader of the free world."

When Clinton first ran for president in 2008, she did not receive Oprah's endorsement. Instead, it went to Barack Obama.