Paine/Speakman, 1832>Ross Co.-Madison Co

Looking for William Paine, married Margaret Speakman in 1832, Ross County.They later moved to Madison County, Ohio.Margaret was born in Maryland, 1811, and the 1880 Madison County census says her parents were from South Carolina.William disappears after the 1850 census for Madison County,but so far I have not found a death anywhere.Any help appreciated!