(Upper) Wild type. The portal tract demonstrates a protal vein and two small duct structures. No portal or lobular inflammation or lobular fatty change is seen. Hematoxylin and eosin x148. (Lower) Mat1atm1Jmm/Mat1atm1Jmm mouse. The portal tract at the left of the field (arrow) shows mild portal lymphocytic infiltrates with an unremarkable bile diet. The hepatocytes adjacent to the portal tract show macrovesicular fatty change. In addition, focal areas of inflammation are also seen involving the liver cells that contain fat (steatohepatitis); the inflammatory component is chiefly lymphocytic. Hematoxylin and eosin x148.