Trigeminal neuralgia or tic douloureux is severe, often debilitating, facial pain that significantly impairs the patient's quality of life and health. Stereotactic radiosurgery has been shown to provide pain relief in majority of patients treated. However, a common side effect of radiosurgery is facial numbness. Our goal is to maximize pain control while minimizing side effects. To this end, the purpose of this study is to evaluate whether adding a drug, amifostine, at the time of radiosurgery will protect patients from facial numbness.

Patients who have previously had an ablative treatment, including prior SRS.

Pediatric patients (age <18), pregnant women, and patients who are unable to give informed consent will be excluded.

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Please refer to this study by its ClinicalTrials.gov identifier: NCT01364259