The work presents first results of radiation therapy with using Tomotherapy TomoHD. For the high quality of patients’ treatment, modern methods of radiotherapy, such as IGRT, IMRT and adaptive radiotherapy are used. Regular performing of machine quality assurance procedures are done according to the local program of QA. A good stability of different machine parameters provides a high quality of patients’ treatment. After the end of the treatment, the partial resorption of targeted lesions and the absence or minimization of early reactions are observed. Tomotherapy provides a fundamentally new and effective treatment for all cancer locations.