Loot Crate's themes change monthly and can be anything from 'Invasion' to 'Anti-Hero' to 'Future'. Loot Crate teams up with companies such as DC, Marvel, and Nintendo to create a large array of merchandise in every crate.

Loot Crate also operates a Loot Anime box with anime-related items.[7] In January 2016 Loot Crate announced a Loot Gaming subscription option with boxes containing video game-related content.[8] The company says that the gaming themed boxes will likely lead to more game-specific cases like the ones for Mass Effect and Fallout 4.[7]

Loot Crate also operated a Loot Pets box that followed the same monthly themes as the regular Loot Crate, but all the items were intended for cats, dogs or other pets. The concept ended on September 2017.