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Nine people were injured in a multiple-vehicle collision that shut down Pacific Coast Highway in Malibu Wednesday afternoon.

First responders work at the site of a major crash in Malibu on Feb. 7, 2018. (Credit: KTLA)

Five to seven vehicles were involved in the crash in the 20100 block of Pacific Coast Highway around 1:30 p.m, stopping traffic on the highway in both directions from Big Rock Drive north to Topanga Canyon Boulevard, according to Caltrans and Los Angeles County fire officials.

The lanes weren't cleared until around five hours later, around 6:30 p.m., when the highway fully reopened, the California Highway Patrol said.

Two crash victims in critical condition were airlifted to the hospital via helicopter, the L.A. County Fire Department said.

Another seven patients were taken to the hospital by ambulance. Four suffered minor injuries, but it was unclear what kind of condition the others were in.

Authorities and onlookers respond to the scene of a multivehicle crash in the 20100 block of Pacific Coast Highway on Feb. 7, 2018. (Credit: KTLA)

It appeared at least two separate crashes had occurred in the same area, video from Sky5 showed.

A white SUV and grey minivan were facing each other, sitting perpendicularly across the southbound lanes. A short distance south, a black pickup was straddling the center divider facing north, a white sedan was perpendicular in northbound lanes, and a red sedan was abutting a white utility truck on the northbound shoulder.

All the vehicles had sustained what appeared to be significant damage.