Research suggests that 5-HTP can improve symptoms of fibromyalgia, including pain, anxiety, morning stiffness, and fatigue. Many people with fibromyalgia have low levels of serotonin, and doctors often prescribe antidepressants. Like antidepressants, 5-HTP raises levels of serotonin in the brain.

5-HTP (5-Hydroxytryptophan) is a building block of serotonin. Serotonin is a powerful brain chemical, and serotonin levels are thought to play a significant role in fibromyalgia pain. Serotonin levels are also associated with depression and sleep.
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For those with fibromyalgia, 5-HTP may help to increase deep sleep and reduce pain. In one study published in the Alternative Medicine Review, researchers reported that supplementation with 5-HTP may improve symptoms of depression, anxiety, insomnia, and fibromyalgia pain. Unfortunately, it is a hit or miss as usual. Some do well, and some experience little relief. Nonetheless, it is worth looking into and mentioning to your primary care physician.

You can’t get 5-HTP from food. The amino acid tryptophan, which the body uses to make 5-HTP, can be found in turkey, chicken, milk, potatoes, pumpkin, sunflower seeds, turnip and collard greens, and seaweed. 5 -HTP is a dietary supplement derived from the amino acid tryptophan. It is a precursor of the neurotransmitter serotonin and the hormone melatonin. Serotonin, as a brain chemical, is associated with pain levels, sleep, and mood. Each of these things plays a factor in the fibromyalgia profile..Health care professionals generally recommend 50 mg of 5-HTP taken 1 to 3 times per day. Some studies have used higher doses, but because 5-HTP can be toxic at high doses, you should talk to your health care provider before raising the dose. Your health care provider can help determine the right dose for you.
For anxiety or depression, the dose is 150 to 300 mg daily.

Because of the potential for side effects and interactions with medications, you should take dietary supplements only under the supervision of your health care provider.