An ancient humanoid race from the Andromeda Galaxy became extinct following the destruction of their homeworld when their sun went supernova. Remnants of the species survived for a time on scattered outposts but eventually died out, leaving their android populations on their own. One of these android-populated outposts was the planetMudd in the Milky Way Galaxy. (TOS: "I, Mudd")

In Star Trek Online, it is revealed in the mission "Uneasy Allies" that the Iconians have rebuilt their numbers inside a Dyson sphere in the Andromeda Galaxy in preparation for an invasion of the Milky Way.