•Related Small Molecules:

Biological Activity

Technical Information

Purity & Documentation

References

Description

Macozinone is a new drug candicate that inhibits decaprenylphosphoryl-β-d-ribose 2′-oxidase (DprE1), more efficiently than BTZ043
target: DprE1
In vitro: PBTZ169, inhibit decaprenylphosphoryl-β-d-ribose 2′-oxidase (DprE1) and display nanomolar bactericidal activity against Mycobacterium tuberculosis in vitro. [1]
In vivo: PBTZ169 can be suspend in 0.25% hydroxy-propylmethyl-cellulose. The administertration for PBTZ169 is 100 mg/kg by gavage. The MIC50 and MIC90 values were 0.0075 and 0.030 μg/mL, respectively. The MIC for PBTZ169 for N. brasiliensis HUJEG-1 was 0.0037 μg/mL.[2] PBTZ169 has improved potency, safety and efficacy in zebrafish and mouse models of tuberculosis (TB). [3]

Clinical Trial

Solvent & Solubility

In Vitro:

DMSO : 6.4 mg/mL (14.02 mM; Need ultrasonic)

Preparing Stock Solutions

ConcentrationSolventMass

1 mg

5 mg

10 mg

1 mM

2.1907 mL

10.9534 mL

21.9068 mL

5 mM

0.4381 mL

2.1907 mL

4.3814 mL

10 mM

0.2191 mL

1.0953 mL

2.1907 mL

*Please refer to the solubility information to select the appropriate solvent.