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It was already one of the most tumultuous days in Grand Slam tennis history, with seven players forced out by injuries, two of the top-3 seeded women eliminated and six former No. 1-ranked players leaving early.

So what else could happen to make this a day like no other at Wimbledon?

Here's what: the world's greatest grass-court player losing on his favourite Centre Court — the most famous stage in tennis — to a 116th-ranked opponent who had never beaten a top-10 player in his life.

Seven-time champion Roger Federer was stunned by Sergiy Stakhovsky in the second round at the All England Club on Wednesday, his earliest loss in a Grand Slam tournament in 10 years.

The 27-year-old Ukrainian outplayed Federer, serving and volleying his way to a 6-7 (5), 7-6 (5), 7-5, 7-6 (5) victory that stands out as one of the sport's biggest upsets.

"Magic," Stakhovsky said. "I couldn't play any better today."

Federer's loss ended his record streak of reaching at least the quarterfinals at 36 consecutive Grand Slam tournaments, a run that began at Wimbledon in 2004, shortly after a third-round exit at that year's French Open.

"It's always a disappointment losing any match around the world, and particularly here," Federer said. "I've had some great moments here, but also some tougher ones. Can't have 'em all. It was a tough loss today."

The result capped a chaotic day of injuries, walkovers, retirements and shock results.

'It's always a disappointment losing any match around the world, and particularly here. I've had some great moments here, but also some tougher ones. Can't have 'em all. It was a tough loss today.'—Roger Federer

Third-seeded Maria Sharapova, the 2004 champion, fell to a 131st-ranked qualifier. No. 2 Victoria Azerenka was among the seven injury withdrawals — believed to be a Grand Slam single-day record in the Open era. Federer became the seventh former No. 1 player to exit the championships on this one day.

Only two days ago, two-time champion Rafael Nadal was bounced in the first round by 135th-ranked Steve Darcis.

After only three days of play, five of the top-10 seeded women and four of the top 10 men are already out of the draw.

The owner of a record 17 major titles and the defending champion here, Federer hadn't been beaten in the second round or earlier at a Slam since a first-round defeat at the 2003 French Open.

The 31-year-old Federer said he won't "panic" and will work hard to come back stronger.

"I'm looking forward to what's to come," he said. "Looking forward to next year, that I can do better next year. "

Federer said the end of his quarter-final run does not represent the end of an era.

"I still have plans to play for many more years to come," he said. " It's normal that after all of a sudden losing early after being in the quarters 36 times, people feel it's different. "

Earliest defeat

Federer's defeat was his earliest at the All England Club since a first-round loss in 2002 to No. 154-ranked Mario Ancic. Stakhovsky is the lowest-ranked player to beat Federer at any event since then.

Most shocking: Wednesday's defeat came on the same grass court Federer has made his own for nearly a decade.

It ended with Stakhovsky converting on his second match point, a 13-stroke rally that finished with Federer hitting a backhand wide.

Stakhovsky fell onto his back in celebration. He later bowed to the crowd as Federer walked off the court with a quick wave.

Federer converted only one of eight break points against Stakhovsky, who broke the Swiss star twice. The Ukrainian piled up 72 winners against 17 unforced errors, while Federer had 56 winners and 13 errors.

While few play serve-and-volley these days, Stakhovsky used the tactic with great success throughout the match to keep Federer off balance. He won 61 out of 96 points at the net.

"I'm still in disbelief," Stakhovsky said. "When you play Roger Federer at Wimbledon it's like you are playing two persons. First you play Roger Federer, then you play his ego, and on the Centre Court of Wimbledon, where he is historical. So that's like playing two against one."

Federer's defeat was the biggest shock on a day full of shocks.

Earlier, third-seeded Sharapova, the 2004 Wimbledon champion, was stunned 6-3, 6-4 by 131st-ranked Michelle Larcher de Brito of Portugal in the second round.

Sharapova slipped and fell several times on the grass on Court 2 and received medical treatment from the trainer in the second set.

It wasn't serious enough to force Sharapova to quit, as so many others did Wednesday either by walkover or mid-match retirements.

In another women's match, Canadian teenager Eugenie Bouchard picked up the biggest victory of her career, beating 12th-seeded Ana Ivanovic, the 2008 French Open champion, 6-3, 6-3 to reach the third round.

Among the casualties: Azarenka (walkover, right knee), men's No. 6 Jo-Wilfried Tsonga (retirement, left knee), John Isner (retirement, left knee) and Darcis (walkover, right shoulder).

In another women's match, Canadian teenager Eugenie Bouchard picked up the biggest victory of her career, beating 12th-seeded Ana Ivanovic, the 2008 French Open champion, 6-3, 6-3 to reach the third round.

The International Tennis Federation said the seven players forced out is believed to be the most in one day at any Grand Slam event in the 45 years of the Open era.

"Very black day," Cilic said of the spate of injury withdrawals. "The other days, other weeks, there were no pullouts. Everything just happened today."

If that wasn't enough, the tournament lost all those former No. 1 players: Sharapova, Azarenka, Caroline Wozniacki, Ana Ivanovic and Jelena Jankovic among the women, and Federer and Lleyton Hewitt among the men.

With Azarenka and Sharapova gone, the prospect of Serena Williams lifting the women's trophy for a sixth time look even stronger. Williams, who is riding a 32-match winning streak, had already been considered the overwhelming title favourite.

There were a few moments of normality on this crazy day at the All England Club.

Andy Murray advances easily

Second-seeded Andy Murray advanced easily to the third round with a 6-3, 6-3, 7-5 victory over Yen-hsun Lu of Taiwan on Court 1.

Murray served 11 aces and had 41 winners against only 14 unforced errors for his second consecutive straight-set win. With Nadal and Federer now out of his half of the draw, the U.S. Open champion remains on course in his bid to become the first British man to win Wimbledon in 77 years.

The 20-year-old Larcher de Brito played the match of her life against Sharapova on Court 2 to reach the third round of a Grand Slam for only the second time.

"I can't believe it," Larcher de Brito said. "I just tried to stay calm. I just played so well. I just hung in there. In the last couple of points or games I just gave it my all and went for it."

Sharapova tumbled several times on the grass. Trailing 3-2 in the second set, her right leg gave way behind the baseline and she did the splits.

Sharapova took a medical timeout and complained to the umpire about the grass conditions. She said later she believed she strained a hip muscle.

"I don't think I've ever fallen three times in a match before in my career, so that was a little strange," Sharapova said. "But that's certainly not an excuse."

The All England Club said it has "no reason to think" the court surface was to blame for the spate of injuries.

"The court preparation has been to exactly the same meticulous standard as in previous years and it is well known that grass surfaces tend to be more lush at the start of an event," the club said in a statement. "The factual evidence, which is independently checked, is that the courts are almost identical to last year, as dry and firm as they should be, and we expect them to continue to play to their usual high quality."

Azarenka, the two-time Australian Open champion, pulled out after hurting her right knee in her opening-round win against Maria Joao Koehler. She withdrew minutes before her second-round match against Flavia Pennetta.

It's only the second time in the Open era that a women's player seeded in the top 2 has conceded a match by walkover at any Grand Slam. The last time it happened was in 1974 at the French Open when second-seeded Nancy Richey pulled out before a match.

Murray's victory came not long after his potential quarter-final opponent, Tsonga, retired with a left knee injury while trailing Ernests Gulbis 3-6, 6-3, 6-3.

Darcis withdrew a few hours before his scheduled match against Lukasz Kubot of Poland. He said he hurt his right shoulder while diving for a shot in the first set of his win against Nadal.

"Not to go on the court today, it's maybe the biggest disappointing thing I have to do," Darcis said.

The tournament also lost 2002 champion Hewitt, who was ousted by 189th-ranked German qualifier Dustin Brown, 6-4, 6-4, 6-7 (3), 6-2.

The dreadlocked Brown, who switched nationality from Jamaica in 2010, was in tears after beating the Australian.

"I cried like a little girl," said Brown, who has played mainly on the lower-tier challenger circuit in 2013 and had never won a match at Wimbledon until this year.

Isner, the 18th-seeded American, retired during his second-round match against Adrian Mannarino of France after only two games.

The retirement came three years after Isner beat Nicolas Mahut 70-68 in the fifth set at Wimbledon in the longest match in tennis history. Now, Isner is out after one of the shortest matches at Wimbledon.

"I always serve and land on my left leg, like I have done 20 million times playing this game, and this is the first time I just felt this sharp pain," he said.