The phenomenon of no- and low-responsiveness has been described after applications of different vaccines (e.g. hepatitis B, TBE) and is concerning about 2-10% of the vaccinees.

The aim of this project is to investigate the humoral and cellular immune responses of low-responders after TBE vaccination in order to find parameters regarding immunoregulation against TBE. It is of interest if non-responsiveness is a general immunological deficit of a distinct patient group or if it is a antigen-specific phenomenon.

Administration of immunoglobulins 6 weeks prior to any vaccination or blood donation during the entire study period

Specific Immune Therapy (Hypo-/Desensibilization) within 14 days before and after the 2 study vaccination doses.

History of any malignant disease 5 years prior to the study entry

Any contraindication for the administration of the TBE- or influenza vaccine according to the manufactures information.

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Please refer to this study by its ClinicalTrials.gov identifier: NCT00804219