When the pets in her neighborhood suddenly go on a rampage, it's Devra Thomas who ends up in the doghouse. It seems a group of primates in a "brain enhancement" experiment have escaped from a nearby research facility. Somehow they are passing on their enhanced brains to all the other animals, and they want their revenge for all the years of humiliation at the hands of their human masters. The animals take over the town and no human is safe.
Luckily, Devra's beloved pooch would never turn on her. Or would she? It's time for a little...payback--bow wow style.