STRING allows inspection of the interaction evidence for any given network. Choose any of the viewers above (disabled if not applicable in your network).

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:query proteins and first shell of interactors

white nodes:second shell of interactors

Node Content

empty nodes:proteins of unknown 3D structure

filled nodes:some 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

SMAC_00984

Hypothetical protein (1178 aa)

Predicted Functional Partners:

SMAC_05396

Hypothetical protein (1947 aa)

0.746

SMAC_04955

Hypothetical protein; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3’-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents (1305 aa)

0.653

SMAC_01674

Hypothetical protein (507 aa)

0.575

SMAC_04895

SGS1 protein (2276 aa)

0.573

SMAC_00168

TOP3 protein; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5’-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3’-OH DNA strand (603 aa)

a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1

node2

node1 accession

node2 accession

node1 annotation

node2 annotation

score

SMAC_00168

SMAC_00984

XP_003351627.1

XP_003350094.1

TOP3 protein; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5’-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3’-OH DNA strand

Hypothetical protein

0.434

SMAC_00168

SMAC_04895

XP_003351627.1

XP_003347587.1

TOP3 protein; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5’-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3’-OH DNA strand

SGS1 protein

0.976

SMAC_00168

SMAC_04955

XP_003351627.1

XP_003352841.1

TOP3 protein; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5’-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3’-OH DNA strand

Hypothetical protein; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3’-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents

0.515

SMAC_00168

SMAC_05396

XP_003351627.1

XP_003347097.1

TOP3 protein; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5’-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3’-OH DNA strand

Hypothetical protein

0.715

SMAC_00168

SMAC_06069

XP_003351627.1

XP_003349374.1

TOP3 protein; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5’-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3’-OH DNA strand

Hypothetical protein

0.627

SMAC_00984

SMAC_00168

XP_003350094.1

XP_003351627.1

Hypothetical protein

TOP3 protein; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5’-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3’-OH DNA strand

0.434

SMAC_00984

SMAC_01674

XP_003350094.1

XP_003348650.1

Hypothetical protein

Hypothetical protein

0.575

SMAC_00984

SMAC_04895

XP_003350094.1

XP_003347587.1

Hypothetical protein

SGS1 protein

0.573

SMAC_00984

SMAC_04955

XP_003350094.1

XP_003352841.1

Hypothetical protein

Hypothetical protein; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3’-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents

0.653

SMAC_00984

SMAC_05396

XP_003350094.1

XP_003347097.1

Hypothetical protein

Hypothetical protein

0.746

SMAC_00984

SMAC_06069

XP_003350094.1

XP_003349374.1

Hypothetical protein

Hypothetical protein

0.409

SMAC_01674

SMAC_00984

XP_003348650.1

XP_003350094.1

Hypothetical protein

Hypothetical protein

0.575

SMAC_04895

SMAC_00168

XP_003347587.1

XP_003351627.1

SGS1 protein

TOP3 protein; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5’-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3’-OH DNA strand

0.976

SMAC_04895

SMAC_00984

XP_003347587.1

XP_003350094.1

SGS1 protein

Hypothetical protein

0.573

SMAC_04895

SMAC_04955

XP_003347587.1

XP_003352841.1

SGS1 protein

Hypothetical protein; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3’-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents

0.489

SMAC_04895

SMAC_05396

XP_003347587.1

XP_003347097.1

SGS1 protein

Hypothetical protein

0.733

SMAC_04895

SMAC_06069

XP_003347587.1

XP_003349374.1

SGS1 protein

Hypothetical protein

0.668

SMAC_04955

SMAC_00168

XP_003352841.1

XP_003351627.1

Hypothetical protein; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3’-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents

TOP3 protein; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5’-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3’-OH DNA strand

0.515

SMAC_04955

SMAC_00984

XP_003352841.1

XP_003350094.1

Hypothetical protein; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3’-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents

Hypothetical protein

0.653

SMAC_04955

SMAC_04895

XP_003352841.1

XP_003347587.1

Hypothetical protein; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3’-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents

SGS1 protein

0.489

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Network Stats

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Functional enrichments in your networkNote: some enrichments may be expected here (why?)

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Statistical background

For the above enrichment analysis, the following statistical background is assumed: