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Special Issue Information

Dear Colleagues,

This issue focuses on the design, synthesis and/or evaluation of bone substitute materials. Appropriate submissions use information about the nanoscale structure of natural bone in a way that allows the synthetic material to duplicate biomechanical and/or cellular behavior of the natural system. Submissions describing attempts to duplicate collagen structures, mineral apatites, ground substance and their hierarchical juxstapositions as found in bone are welcome. All submissions must clearly connect material composition and/or structure with the desired mechanical and/or biological function of the biomaterial. Authors are encouraged to include a section in each manuscript devoted to explaining how the materials science and engineering aspects of the work are related to solving an outstanding clinical problem.

It is my pleasure to invite you to submit a manuscript for this Special Issue. Full papers, communications, and reviews are all welcome.

Assoc. Prof. Steven J. EppellGuest Editor

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Titanium metal (Ti) and its alloys are widely used in orthopedic and dental fields. We have previously shown that acid and heat treatment was effective to introduce bone bonding, osteoconduction and osteoinduction on pure Ti. In the present study, acid and heat treatment

Titanium metal (Ti) and its alloys are widely used in orthopedic and dental fields. We have previously shown that acid and heat treatment was effective to introduce bone bonding, osteoconduction and osteoinduction on pure Ti. In the present study, acid and heat treatment with or without initial NaOH treatment was performed on typical Ti-based alloys used in orthopedic and dental fields. Dynamic movements of alloying elements were developed, which depended on the kind of treatment and type of alloy. It was found that the simple acid and heat treatment enriched/remained the alloying elements on Ti–6Al–4V, Ti–15Mo–5Zr–3Al and Ti–15Zr–4Nb–4Ta, resulting in neutral surface charges. Thus, the treated alloys did not form apatite in a simulated body fluid (SBF) within 3 days. In contrast, when the alloys were subjected to a NaOH treatment prior to an acid and heat treatment, alloying elements were selectively removed from the alloy surfaces. As a result, the treated alloys became positively charged, and formed apatite in SBF within 3 days. Thus, the treated alloys would be useful in orthopedic and dental fields since they form apatite even in a living body and bond to bone.
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