Coriander improves circulation to the brain and improves memory and concentration, and has been studied as a means to control blood sugar.

For a free nutritional consultation and/or AgePrint quiz, and for all of your supplement needs, call THN today—and don’t forget to ask about the 50% discount on the new edition of the PATH Wellness Manual.

APOE ε4 Gene—Predictor of Cognitive Performance in Parkinson DiseaseAmong PD patients without dementia, the APOE ε4 allele was only associated with lower performance on word list learning and semantic verbal fluency, a pattern more typical of the cognitive deficits seen in early Alzheimer disease than PD. – JAMA, September 2014​The Preclinical Alzheimer Cognitive Composite Measuring Amyloid-Related DeclineAnalyses of at-risk cognitively-normal populations suggest that we can reliably measure the first signs of cognitive decline with the ADCS Preclinical Alzheimer Cognitive Composite (ADCS-PACC). The ADCS-PACC combines tests that assess episodic memory, timed executive function, and global cognition. – JAMA, September 2014

Obsessive-Compulsive Disorder as a Risk Factor for SchizophreniaIn a national cohort study, an elevated risk of schizophrenia and schizophrenia spectrum disorders was observed in association with a prior diagnosis of OCD in the patients and the parents. The observed increase in risk suggests that OCD, schizophrenia, and schizophrenia spectrum disorders probably lay on a common etiological pathway. – JAMA, September 2014

Brain Morphometric Biomarkers Distinguishing Unipolar and Bipolar DepressionA cross-sectional study has shown that individuals with Unipolar Depression and those with Bipolar Depression are differentiated by structural abnormalities in neural regions supporting emotion processing, based on neuroimaging and multivariate pattern classification techniques. – JAMA, September 2014Apolipoprotein E Genotype and the Diagnostic Accuracy of Cerebrospinal Fluid Biomarkers for Alzheimer DiseaseSeveral studies suggest that cerebrospinal fluid levels of Aβ42 are strongly associated with the diagnosis of Alzheimer’s disease and cortical Aβ accumulation independent of APOE genotype. – JAMA, August 2014

High-Frequency Deep Brain Stimulation for Treatment of Parkinson DiseaseHigh-frequency stimulation of the subthalamic nucleus improves motor function and quality of life, and provides better results than the best medical therapy for advanced Parkinson’s disease. – JAMA, September 2014

Higher Working Memory Predicts Slower Functional Decline in ADPreservation of working memory, but not episodic memory, in the mild cognitive impairment and early dementia stages of Alzheimer’s disease relates to slower rate of functional decline. – Dementia and Geriatric Cognitive Disorders, August 2014

Association of Poor Subjective Sleep Quality With Risk for Death by Suicide During a 10-Year PeriodA longitudinal case-control cohort study of late-life suicide indicates that poor subjective sleep quality is associated with increased risk for death by suicide 10 years later, even after adjustment for depressive symptoms. – JAMA, September 2014

Glucose Levels and Risk of DementiaStudies from the National Institutes of Health suggest that higher glucose levels may be a risk factor for dementia, even among persons without diabetes. – NEJM, September 2014

Half of Dementia Patients Prescribed Medications of Questionable BenefitPharmacy records revealed that 54% of elderly nursing home patients received at least one of what the researchers called “medications of questionable benefit”: more than a third were given a cholinesterase inhibitor (Aricept), a quarter received memantine (Namenda), more than 20% were on statins to lower cholesterol, and 7% were on blood thinners. All of these drugs were deemed “never appropriate” for palliative care patients with advanced dementia, in a list developed by a panel of geriatricians and published in the Journal of the American Geriatrics Society. – JAMA, September 2014

Weight Loss DrugsBoth lorcaserin (Belviq) and the phentermine/topiramate ER combination (Qsymia) taken as adjuncts to diet and exercise may be effective in increasing weight loss in the first year of use, but much less so in the second year. Qsymia appears to be more effective than locaserin, but may cause more troublesome adverse effects. – JAMA, September 2014

Statins and Cognitive FunctionDespite the FDA warning regarding cognitive impairment, published data do not suggest an adverse effect of statins on cognition; however, the strength of available evidence is limited, particularly with regard to high-dose statins. – Anals of Internal Medicine, August 2014

Self-reported Head Injury Linked to Early DementiaSelf-reported head injury is associated with earlier onset and increased risk of cognitive impairment and dementia, increased risk of mortality, and Alzheimer’s disease-type pathological changes. – Dementia and Geriatric Cognitive Disorders, August 2014

Effect of Physical Exercise on Cognitive Performance in Older Adults with Mild Cognitive Impairment or DementiaNumerous studies have shown that physical exercise has positive effects on cognition in healthy adults, and randomized controlled studies on older subjects with MCI reported some positive effects on cognition, mainly on global function, attention, and delayed recall. However, most studies performed on older subjects with dementia showed no effect of exercise on cognition. – Dementia and Geriatric Cognitive Disorders, August 2014

Association of Lifetime Intellectual Enrichment with Delayed Cognitive Decline in the Older PopulationLifetime intellectual enrichment might delay the onset of cognitive impairment and be used as a successful preventive intervention to reduce the impending dementia epidemic. Higher education/occupation scores were associated with higher levels of cognition. Higher levels of mid/late-life cognitive activity were also associated with higher levels of cognition, but the slope of this association slightly increased over time. – JAMA, August 2014

Eric R. Braverman, M.D.

Dr. Braverman is a Summa Cum Laude and Phi Beta Kappa graduate of Brandeis University and NYU Medical School, did brain research at Harvard Medical School, and trained at an affiliate of Yale Medical School. He is acknowledged worldwide as an expert in brain-based diagnosis and treatment, and he lectures to and trains doctors in anti-aging medicine.

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