Justification:Brachycereus nesioticus is found on several islands of the Galápagos archipelago, it is known from at least 11 subpopulations and it is thought to be widespread on recent lava flows, but individuals are dispersed and the area of occupancy is small. There are no major threats to the species and it is therefore listed as Least Concern.

Brachycereus nesioticus is endemic to the Galápagos Islands (Ecuador), where it is found on the islands of Bartolomé, Fernandina, Genovesa, Isabela, Pinta and San Salvador (Hunt et al. 2006). The area of occupancy is probably less than 100 km2.

This succulent shrub forms dense clumps which grow on lava flows in the arid parts of the islands and is generally found amongst open vegetation. It is one of the first species to colonize fresh lava flows.

The whole range of the species is protected by the Galápagos National Park and Natural World Heritage Site. The species is listed on CITES Appendix II and collecting is prohibited by the Government of Ecuador.