This is a 30-year-old woman G3, P2. She had no relevant past medical or obstetric history or no exposure to any medicines. The gestational age had been previously confirmed during the first trimester by crown rump length measurement at 12 weeks of gestation. The nuchal translucency was measured (1 mm) and the maternal risk for trisomy 21 was normal.

Subsequent sonogram at 20 weeks of gestation showed an abnormal fetus. Biometry was found to be abnormal and there were brain and limb malformations. The following anomalies were noted:

Equine position of the right feet with tibial agenesis

Clubbed position of the right hand and wrist contraction

Bilateral plexus choroid cyst

Hypoplasia of the vermis

Cholecystomegaly

The pregnancy was terminated and all the anomalies were confirmed on the fetus.