… We found that analgesic tolerance to morphine developed with significant delay in mice lacking vasopressin V1b receptors (V1bRs) and in mice administered with a V1bR antagonist, but not in V1a-deficient mice. …

Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 1-S15-4, 2020

… <p>In the paraventricular (PVN) and supraoptic nuclei (SON) of the hypothalamus, oxytocin and arginine-vasopressin (AVP) are synthesized to cause the lactation and reabsorption of water in the kidney, respectively. …

Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 1-P-010, 2020

… Oxytocin and vasopressin, neuropeptides mainly generated in hypothalamus, have emerged as key molecules in prosocial signaling. … However, how oxytocin and vasopressin work in the brain during the prosocial activities remains elusive, due to the lack of the method that allows the real-time monitoring of oxytocin and vasopressin in behaving animals. …

Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 1-P-005, 2020