Oxycodone

oxycodone

Basic Information

Summary

A semisynthetic opioid analgesic developed in 1917, prescribed primarily for pain management. It has become extremely popular as a recreational drug in some areas, and carries a high potential for addiction. Reported as being a little more 'stimulating' than other opioids.

Common drugs are those which are well known and widely used among the drug community. This doesn't necessarily mean they are safe, but it usually comes with a longer relative history of use in humans with which to establish a safety profile.

Dose

Oral

Light

2.5-10mg

Common

10-25mg

Strong

25-40mg

Insufflated

Light

2.5-7.5mg

Common

7.5-15mg

Strong

15-25mg

Duration

Oral_IR

Onset

20 minutes

Duration

4-6 hours

After-effects

1-24 hours

Oral_ER

Onset

40 minutes

Duration

6-8 hours

After-effects

1-24 hours

Insufflated

Onset

2-5 minutes

Duration

3-5 hours

After-effects

1-24 hours

IV

Onset

0-1 minutes

Duration

3-5 hours

After-effects

1-24 hours

Potentiators

Avoid grapefruit juice, alcohol, and diphenhydramine. These products may react negatively and cause an overdose. Also do not consume more than 4g APAP (acetaminophen) in a day.

Interactions

Dangerous

Both substances bring a risk of vomiting and unconsciousness. If the user falls unconscious while under the influence there is a severe risk of vomit aspiration if they are not placed in the recovery position.

Both substances potentiate the ataxia and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. Place affected patients in the recovery position to prevent vomit aspiration from excess. Memory blackouts are likely

Concomitant use of tramadol increases the seizure risk in patients taking other opioids. These agents are often individually epileptogenic and may have additive effects on seizure threshold during coadministration. Central nervous system- and/or respiratory-depressant effects may be additively or synergistically present

Central nervous system and/or respiratory-depressant effects may be additively or synergistically present. The two substances potentiate each other strongly and unpredictably, very rapidly leading to unconsciousness. While unconscious, vomit aspiration is a risk if not placed in the recovery position Blackouts/memory loss likely

Caution

Both substances potentiate the ataxia and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. While unconscious, vomit aspiration is a risk if not placed in the recovery position. Memory blackouts are likely.

Coadministration of monoamine oxidase inhibitors (MAOIs) with certain opioids has been associated with rare reports of severe and fatal adverse reactions. There appear to be two types of interaction, an excitatory and a depressive one. Symptoms of the excitatory reaction may include agitation, headache, diaphoresis, hyperpyrexia, flushing, shivering, myoclonus, rigidity, tremor, diarrhea, hypertension, tachycardia, seizures, and coma. Death has occurred in some cases.