It is true! look at Miguel Cotto, Ricky Hatton, ODLH. What do those guys have in common? They are left hookers. Oscar and Cotto are lefty's with orthodox stance. Those kind of boxers are allergic to soutpaws . The left hook is easily neutralized by a good southpaw by having their lead foot outside of the orthodox fighter. To be truly effective against a southpaw you need that right cross or the right hook. On top of that, Manny had a clear speed advantage. Miguel Cotto was damaged goods after the Margarito fight had to make 145 cathweight limit. ODLH was shot and hadn't made the 147lb limit in 7 years and the fight was a 145lb cathweight. Also he never could handle southpaws. Ricky Hatton was to slow and his main weapon is that left hook, easily neutralized. Also Floyd Mayweather had knocked him out and Manny have far more power than PBF. Margarito was completely drained making the 150lb catchweight and a slow crude brawler that was made to make Manny look good.