Large gene clusters in filamentous fungi are regulated by the underlying chromatin structure, a combination of DNA, proteins and RNA. We wish to determine how genes within secondary metabolite clusters are silenced or expressed as a consequence of posttranslational modifications on histone proteins. To this end we generate mutants, make gene deletion constructs and carry out protein complex isolations. The long-term goal is to generate a regulatory network that explains how large chromatin regions are coordinately silenced or expressed.