From The Collaborative International Dictionary of English v.0.48 [gcide]:
Plague \Plague\, n. [L. plaga a blow, stroke, plague; akin to
Gr. ?, fr. ? to strike; cf. L. plangere to strike, beat. Cf.
{Plaint}.]
1. That which smites, wounds, or troubles; a blow; a
calamity; any afflictive evil or torment; a great trail or
vexation. --Shak.
[1913 Webster]
And men blasphemed God for the plague of hail.
--Wyclif.
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The different plague of each calamity. --Shak.
[1913 Webster]
2. (Med.) An acute malignant contagious fever, that often
prevails in Egypt, Syria, and Turkey, and has at times
visited the large cities of Europe with frightful
mortality; hence, any pestilence; as, the great London
plague. "A plague upon the people fell." --Tennyson.
[1913 Webster]
{Cattle plague}. See {Rinderpest}.
{Plague mark}, {Plague spot}, a spot or mark of the plague;
hence, a token of something incurable.
[1913 Webster]
From The Collaborative International Dictionary of English v.0.48 [gcide]:
Plague \Plague\, v. t. [imp. & p. p. {Plagued}; p. pr. & vb. n.
{Plaguing}.]
1. To infest or afflict with disease, calamity, or natural
evil of any kind.
[1913 Webster]
Thus were they plagued
And worn with famine. --Milton.
[1913 Webster]
2. Fig.: To vex; to tease; to harass.
[1913 Webster]
She will plague the man that loves her most.
--Spenser.
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Syn: To vex; torment; distress; afflict; harass; annoy;
tease; tantalize; trouble; molest; embarrass; perplex.
[1913 Webster]
From WordNet (r) 3.0 (2006) [wn]:
plague
n 1: a serious (sometimes fatal) infection of rodents caused by
Yersinia pestis and accidentally transmitted to humans by
the bite of a flea that has bitten an infected animal [syn:
{plague}, {pestilence}, {pest}, {pestis}]
2: any epidemic disease with a high death rate [syn: {plague},
{pestilence}, {pest}]
3: a swarm of insects that attack plants; "a plague of
grasshoppers" [syn: {infestation}, {plague}]
4: any large scale calamity (especially when thought to be sent
by God)
5: an annoyance; "those children are a damn plague"
v 1: cause to suffer a blight; "Too much rain may blight the
garden with mold" [syn: {blight}, {plague}]
2: annoy continually or chronically; "He is known to harry his
staff when he is overworked"; "This man harasses his female
co-workers" [syn: {harass}, {hassle}, {harry}, {chivy},
{chivvy}, {chevy}, {chevvy}, {beset}, {plague}, {molest},
{provoke}]

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