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Abstract

Cancers of the soft tissue reign among the deadliest diseases throughout the world and effective treatments for such cancers rely on early and accurate detection of tumors within the interior of the body. One such diagnostic tool, known as elasticity imaging or elastography, uses measurements of tissue displacement to reconstruct the variable elasticity between healthy and unhealthy tissue inside the body. This gives rise to a challenging parameter identification inverse problem, that of identifying the Lamé parameter μ in a system of partial differential equations in linear elasticity. Due to the near incompressibility of human tissue, however, common techniques for solving the direct and inverse problems are rendered ineffective due to a phenomenon known as the “locking effect”. Alternative methods, such as mixed finite element methods, must be applied to overcome this complication. Using these methods, this work reposes the problem as a generalized saddle point problem along with a presentation of several optimization formulations, including the modified output least squares (MOLS), energy output least squares (EOLS), and equation error (EE) frameworks, for solving the elasticity imaging inverse problem. Subsequently, numerous iterative optimization methods, including gradient, extragradient, and proximal point methods, are explored and applied to solve the related optimization problem. Implementations of all of the iterative techniques under consideration are applied to all of the developed optimization frameworks using a representative numerical example in elasticity imaging. A thorough analysis and comparison of the methods is subsequently presented.

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