•Related Small Molecules:

Biological Activity

Technical Information

Purity & Documentation

References

Description

Danshensu (sodium salt) is odium salt of danshensu from the widely used Chinese herb Danshen. It can inhibited phenylephrine- and CaCl2-induced vasoconstriction in Ca2+-free medium.
In vitro: Sodium danshensu showed a biphasic effects on vessel tension. While low dosage of sodium danshensu produced small contraction possibly through transient enhancement of Ca2+ influx, high dosage produced significant vasodilation mainly through promoting the opening of non-selective K+ channels and small-conductance calcium-sensitive K+ channels in the vascular smooth muscle cells.[1]In vivo: Danshensu did not change the expression of AGEs but partly blocked the increased expression of RAGE in the hippocampus of diabetic mice. Danshensu could ameliorate the cognitive decline in streptozotocin-induced diabetic mice by attenuating advanced glycation end product-mediated neuroinflammation.[2]

Solvent & Solubility

In Vitro:

H2O : ≥ 33 mg/mL (149.90 mM)

*"≥" means soluble, but saturation unknown.

Preparing Stock Solutions

ConcentrationSolventMass

1 mg

5 mg

10 mg

1 mM

4.5424 mL

22.7118 mL

45.4236 mL

5 mM

0.9085 mL

4.5424 mL

9.0847 mL

10 mM

0.4542 mL

2.2712 mL

4.5424 mL

*Please refer to the solubility information to select the appropriate solvent.