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TNF-α Antagonist, also designated WP9QY is an exocyclic peptidomimetic that acts as a TNF-α antagonist by mimicking the most critical recognition loop on TNF receptor I, thus preventing interaction with the receptor. By blocking the TNFR ligand contact site, the peptide blocks bone resorption by interfering with recruitment and activation of osteoclasts by both RANKL and TNF. Useful for the development of small molecular inhibitors related to the prevention of systemic bone loss in rheumatoid arthritis and inflammatory bone destruction. The designation WP9QY arises from the binding to the site observed in the TNF receptor complex.

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TNFTNF- Antagonist is a peptide that has been reported to imitate the TNF-alpha recognition loop on TNF receptor I complex. This imitation causes interferences with both TNF-alpha's recruitment and activation of osteoclasts and activating receptor activator of NF-kappaB (RANK). In many studies, TNF-alpha antagonist is also known to block bone resorption in rheumatoid arthritis. -SCBT Publication Review

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