Description

Associated products

Specifications

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Applications

Blocking

FormLiquid

Additional notes

This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and AIB 1, catalog ab2831. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~ 70-fold) for competitive inhibition of antibody-protein binding reactions.

Concentration information loading...

Preparation and Storage

Stability and Storage

Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

General Info

Alternative names

ACTR

AIB 1

AIB-1

AIB1

Amplified in breast cancer 1

Amplified in breast cancer 1 protein

bHLHe42

CAGH 16

CAGH16

CBP interacting protein

CBP-interacting protein

Class E basic helix-loop-helix protein 42

CTG 26

CTG26

KAT13B / AIB1

MGC141848

NCOA 3

NCoA-3

Ncoa3

NCOA3_HUMAN

Nuclear receptor coactivator 3

pCIP

RAC 3

RAC-3

RAC3

Receptor associated coactivator 3

Receptor-associated coactivator 3

SRC 3

SRC-3

SRC3

Steroid receptor coactivator protein 3

Thyroid hormone receptor activator molecule 1

TNRC14

TNRC16

TRAM 1

TRAM-1

TRAM1

see all

FunctionNuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit. Interacts with PSMB9.

Tissue specificityWidely expressed. High expression in heart, skeletal muscle, pancreas and placenta. Low expression in brain, and very low in lung, liver and kidney.

DomainContains three Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. Motifs 1 and 2 are essential for the association with nuclear receptors, and constitute the RID domain (Receptor-interacting domain).

Post-translationalmodificationsAcetylated by CREBBP. Acetylation occurs in the RID domain, and disrupts the interaction with nuclear receptors and regulates its function.Methylated by CARM1.Phosphorylated by IKK complex. Regulated its function.

Cellular localizationCytoplasm. Nucleus. Mainly cytoplasmic and weakly nuclear. Upon TNF activation and subsequent phosphorylation, it translocates from the cytoplasm to the nucleus.