City, who are favourites to win this season's competition with some bookmakers, fell further behind before half-time - Lyon captain Fekir finding the net from 25 yards after Fernandinho gave the ball away inside his own half.

Bernardo Silva gave the hosts a lifeline after being picked out by Leroy Sane, but City - lacklustre for long spells - were unable to avoid a first defeat of the season.

With Group F rivals Shakhtar Donetsk and Hoffenheim drawing 2-2 in Ukraine earlier on Wednesday, City are bottom of the group.

They also became the first English side in Champions League history to lose four consecutive matches in the competition having also been beaten in last season's last-16 second leg by Basel, as well as both legs of the quarter-final against Liverpool.

City miss Guardiola's presence

City, looking to replicate their domestic dominance in Europe, were a shadow of the side that swept to 100 points in the Premier League last season.

French defender Aymeric Laporte headed against the outside of the post from Ilkay Gundogan's cross, while Gabriel Jesus and Sergio Aguero were denied by excellent saves from Anthony Lopes.

City, however, appeared to miss Pep Guardiola's direction from the sidelines.

The City boss watched his side's wretched performance from a seat high in the stand as he served a touchline ban following his sending-off in last season's Champions League quarter-final defeat against Liverpool.

Manchester City won all three Champions League group home games last season

Assistant coach Mikel Arteta took over duties in the dugout but the former Arsenal midfielder oversaw a disjointed performance which was as flat as the atmosphere inside the ground.

Silva's goal, after Sane had glided past ex-Manchester United defender Rafael midway in the second half, reinvigorated his side.

However, City now find themselves playing catch up in a group they were expected to dominate.

Guardiola's side made it to the last eight of the Champions League last season and have never gone beyond the semi-finals.

Fekir inspires razor-sharp Lyon

Lyon could have been forgiven for fearing their visit to the Etihad.

Lying seventh in Ligue 1, they already trail leaders Paris St-Germain by eight points just five games into the season.

Yet they were effective at both ends of the pitch as they executed the perfect gameplan to stun the champions of England.

Jason Denayer, who left City for Lyon in August without making a first-team appearance, was impressive at the back while ex-Manchester United forward Memphis Depay hit the post at 2-0 from another sweeping counter-attack.

Fekir led by example. The Lyon skipper, heavily linked with a move to Liverpool in the summer, made one goal and scored the other.

Lyon finished third in Ligue 1 last season and are currently seventh in the table after five games

Portuguese keeper Lopes also inspired his side, the save from substitute Aguero in the dying moments a pivotal moment.

Lyon lost at Reims in their first domestic away game this season and drew at Caen in the other.

Yet their Champions League campaign is off to a flying start following a night which will live long in the memory of their travelling fans.

Man of the match - Nabil Fekir (Lyon)

Outstanding performance by the Lyon captain. Since last season, the French forward has been directly involved in 34 goals for Lyon in all competitions. Only Memphis Depay (42) has had a hand in more for the club

Unwanted history

City have become only the second English side to lose three consecutive home Champions League matches. Tottenham Hotspur lost three in a row between April 2011 and November 2016.

French clubs have now won four of their last nine visits to English sides in the Champions League (D2, L3), as many as the previous 27 such matches combined.

City found themselves two or more goals down in a match at the Etihad for the first time since they lost 3-1 to Chelsea in December 2016.

Six of the past eight instances of Manchester City conceding twice in the first half of a match at the Etihad have been in the Champions League.

Only Sergio Aguero (20) has scored more goals in all competitions for Man City during 2018 than Bernardo Silva (9).

What's next?

City's next European test is in Germany on 2 October when they meet Julian Nagelsmann's Hoffenheim (17:55 BST). On the same evening, Lyon host Shakhtar Donetsk (20:00 BST).