Antidiabetic Herbs

Anti-Diabetic Herbs in Siddha system of Medicine International Journal of Pharmaceutical Archive-3(3), 2014, 338-345 Available online through www.ijpaonline.info ISSN 2319-7226 REVIEW ARTICLE A REVIEW ON ANTI-DIABETIC HERBS IN SIDDHA MEDICINE Parthiban.P1*, Thillaivanan.S2, Kanakavalli.K3, Deporal.P4, Chilambu selvi.P4, and Kalpana.A4 1HOD, Department of Pothu Maruthuvam - PG, GSMC, Chennai, India. 2AssistantMedical officer, GPHC, Jamunamarathur, TamilNadu, India. 3HOD, Department of Pothu Maruthuvam - UG, GSMC, Chennai, India. 4PG scholar, Department of Pothu Maruthuvam, GSMC, Chennai, India. (Received on: 06-03-14; Revised & Accepted on: 13-03-14) ABSTRACTDiabetes mellitus is a metabolic disorder in which a person has high blood sugar, either because the pancreas doesnot produce enough insulin or because cell does not respond to the insulin that is produced. The symptoms related withdiabetes are polyuria [frequent urination], polydipsia [increased thirst], polyphagia [increased hunger] and loss ofweight. IDDM treated with a combination of regular and NPH insulin or synthetic insulin. The oral hypoglycemicagents [OHAs] like Metformin used for NIDDM all around world widely. In present days worlds focus turns to theherbal medicine because of the side effect of modern drugs. Many herbs have anti-diabetic, anti- hyperglycemicactivity. Siddha medical system is very powerful system of Indian system of medicine. It is treating the diseases usingherbs, inorganic substances and animal products. Many of the siddha medicinal plants possess the anti- diabeticproperty. Siddha medicine has better remedies for treatment and management of diabetes. This article reviews the anti-diabetic activity of the most common herbs in siddha medicine. This review may be supportive for the resear
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Development Of New Anti-diabetic Drug From Medicinal Plant-genomic Research

Commentary - Journal of Diabetology (2018) Volume 2, Issue 1 Development of new anti-diabetic drug from medicinal plant-genomic research Kalpana Chawla Center for Space and Nano Science, Indian Institute of Chemical Biology, India Kalpana Chawla Center for Space and Nano Science Citation: Chakraborty P. Development of new anti-diabetic drug from medicinal plant-genomic research. J Diabetol. 2018;2(1):6-7 Visit for more related articles at Journal of Diabetology Diabetes mellitus is considered as one of the five leading causes of death in the world. The global prevalence of diabetes was 3-4% in 2000, and expected to increase to 4.5-5.5% by 2030, and WHO has predicted that the major burden will go to developing countries. Nearly 60-80% of the worlds population uses traditional medicines derived from medicinal plants for various diseases including diabetes. Since time immemorial traditional plants have played a very crucial role in treatment, prevention, mitigation and cure of the different diseases. There are huge numbers of plants that are having anti-diabetic properties. Some plants like O sanctum possess antidiabetic, anti-cancer, anti-fertility, analgesic properties. Many pre-clinical studies have been documented that shows anti-diabetic and hypoglycemic effects of O sanctum through various postulated mechanisms. A huge number of medicinal plants with potential antidiabetic activity have been listed which may include: Azadirachta indica its leaves, stem bark and seeds possess hypoglycemic activity via increasing insulin secretion from pancreatic beta-cells similarly, Grewia asiatica has antioxidant and radical scavenging activity. But in spite of having huge number of medicinal plants worldwide, there are not many biologically active antidiabetic molecules/drugs in o
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Seven Herbs And Supplements For Type 2 Diabetes

Diabetes is a widespread disorder affecting the blood sugar and insulin levels in the body. Managing the long-term consequences and complications of diabetes are as much of a challenge as the disease itself. There are two main types of diabetes. Type 1 diabetes is where the pancreas produces no insulin. Type 2 diabetes is more common. With type 2, the body either does not produce enough insulin or produces insulin that the body does not use properly. There are many treatment options for people with type 2 diabetes. Growing research suggests that some herbs and supplements may help with the condition. Useful herbs may be great to combine with more traditional methods to find relief from many type 2 diabetes symptoms. Seven herbs and supplements Here are seven herbs and supplements that may be of benefit to people with type 2 diabetes. Aloe vera Aloe vera is a common plant with many different uses. Most people are aware of the plant being used to coat the skin and protect it from damage caused by too much sun exposure. However, the plant has many lesser-known benefits as well. These range from helping digestive issues to possibly even relieving type 2 diabetes symptoms. One review analyzed many studies using aloe vera to treat symptoms of diabetes. Their results strongly suggested an antidiabetic potential for aloe. Subjects given aloe showed lower blood sugar levels and higher insulin levels. Further tests showed that aloe helps to increase how much insulin is produced by the pancreas. This could mean that aloe helps to restore bodies with type 2 diabetes or protect them from further damage. The researchers called for more studies to be done on aloe and its extracts to be certain of these effects. There are many ways to take aloe. Juiced pulp is sold in many markets and
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Promising Antidiabetic Drugs, Medicinal Plants and Herbs: An Update Mohd Iqbal Yatoo , Archana Saxena , Arumugam Gopalakrishnan , Mahmoud Alagawany and Kuldeep Dhama Diabetes is a chronic endocrine disease with global prevalence and rising incidence. Diabetes represents a major health issue in all age groups in the present times owing to its multisystem involvement and serious complications. Despite drug development and therapeutic interventions, successful treatment of diabetes still remains a challenge and worldwide research is focused on these aspects. Conventional antidiabetic medicines include injectable insulins, sulfonylureas, biguanides, glucosidase inhibitors and glinides. New class include inhalable insulins, incretin mimetics, amylin analogues, gastric inhibitory polypeptide analogues, peroxisome proliferator activated receptors and dipeptidyl peptidase-4 inhibitors. From effectiveness of synthetic drugs, chemicals or hormones to issues of cost, availability and side effects, novelty in preparations to methods of administration, all fields are explored for better management of the disease. Medicinal plants with antidiabetic potential have been recent areas of research. Asteraceae, Araliaceae, Cucurbitaceae, Lamiaceae, Leguminoseae, Liliaceae, Moraceae and Rosaceae are the major antidiabetic plant families. The most active plants are Allium sativum, Gymnema sylvestre, Citrullus colocynthis, Trigonella foenum greacum, Momordica charantia and Ficus bengalensis. Their phytoconstituents have shown promising results in diabetes management; but need to be properly evaluated at molecular, physiological, pharmacological and toxicological levels for various prophylactic and therapeutic attributes, mechanisms of action, efficacy and safety before application in diabete
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A comprehensive review on ethno pharmacological antidiabetic potential of traditional ayurvedic plants of Bangladesh Author: Abu Zaffar Shibly, Fatama Tous Zohora, Md. Shariful Islam, Md. Rafiad Islam Abstract: Diabetes mellitus (DM) is a common and metabolic disorder throughout the world. In recent years, there have been various types of research and survey works are studied. Bangladesh is the land of beauty whereas the natural plants have exclusive medicinal ayurvedic activity against Insulin Dependent Diabetic Mellitus (IDDM) and Non-Insulin Dependent Diabetic Mellitus (NIDDM). Among many medications and other alternative medicines, several herbs have been known to cure and control diabetes; additionally they have no side effects. In the last few years, there has been an exponential growth in the field of herbal medicine and gaining popularity both in developing and developed countries because of their natural origin and less side effects. In this review work, we just figure out some potential herbal plants (25) antidiabetic activity in Bangladesh. A comprehensive review of the present paper is an attempt to list of the plants with anti-diabetic and related beneficial effects originating from different parts of world. History showed that medicinal plants have been used in traditional healing around the world for a long time to treat diabetes; this is because such herbal plants have hypoglycemic properties and other beneficial properties, as reported in scientific literature. This work enhanced the future researchers for further research on the potential use of medicinal plants having antidiabetic potential including hypoglycemic activity, insulin mimetic activity and antioxidant activity.
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Antidiabetic Medicinal Plants And Their Mechanisms Of Action

Antidiabetic Medicinal Plants and Their Mechanisms of Action Diabetes is one of the prominent metabolic disorders nowadays. It is associated with many complications, including polyuria, weight loss, polydipsia, polyphagia, blurred vision, retinopathy, neuropathy, and nephropathy. Ongoing research has advanced on the mechanisms accompanying the prevention and treatment of diabetes, and the vast majority of research papers in the field of drug design and pharmacokinetics concentrate on the mechanisms through which the homeostasis of serum glucose is achieved. Several organs are fundamental in the process of regulating blood glucose levels, namely, the pancreas, liver, muscles, and adipose tissues. On the one hand, pancreatic -islets are responsible for insulin production. As such, some drugs are focused to augment the islet size, cell size and number, or insulin secretion levels. On the other hand, the liver is the most crucial organ to sense fluctuations in blood glucose concentration and respond via buffering mechanisms accordingly. Furthermore, muscle and adipose tissues play concomitant roles to withdraw extra glucose from the bloodstream. Several key enzymes (e.g., phosphofructokinase, phosphorylase, glucose-6-phosphatase, etc.), transporters (GLUT2, GLUT4, etc.), as well as cell surface receptors (IRS, TM7, and others) in the hepatic, muscular, and adipose tissues are major targets for antidiabetic drugs. Global control of blood glucose levels can be via insulin-dependent protein kinase B (PKB) or insulin-independent AMP-activated protein kinase (AMPK) signaling cascades. Additionally, several drugs target to soothe the cell damage associated with hyperglycemia. In this respect, antioxidants have invaluable effects that should not be ignored. Moreover, the simple r
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A Review On Herbs Which Are Used In Diabetes Mellitus

A Review on Herbs which are Used in Diabetes Mellitus Debashish Paramanick 1 * and Neeraj Sharma 2 1 Columbia Institute of Pharmacy, Tekari, Raipur, India 2 College of Pharmacy, IPS Academy, Indore, India Received date: June 03, 2017; Accepted date: July 07, 2017; Published date: July 07, 2017 Citation: Paramanick D, Sharma N (2017) A Review on Herbs which are Used in Diabetes Mellitus. Int J Drug Dev & Res 9:12-17 Visit for more related articles at International Journal of Drug Development and Research A metabolic disarray typified through the prevalence of unceasing hyperglycemia is referred to as diabetes which is immune-mediated (Type 1 diabetes), insulin resistance (Type 2), gestational or others (surroundings, hereditary defect, infection and assured drugs). A lot of chemical agents are available to manage and to treat hyperglycemic patients, but entire revitalization from diabetes has not been accounted up to this date. The recent oral hypoglycemic agents generate unwanted consequences. A plant by virtue of its symphony of having numerous components urbanized throughout its development beneath diverse ecological strains presents a superfluity of compound families amid therapeutic usefulness. Due to lesser side effect and low cost the herbal formulations are becoming popular now days particularly in curing the disease. This review spotlights on the probability of diverse polyherbal formulation in the management of hyperglycemia along with their pharmacological exploration. Diabetes mellitus; Hyperglycemia; Metabolic disarray;Hypoglycemic agents; Herbal formulations A group of metabolic ailments exemplified through hyperglycemia termed as diabetes mellitus fallouts from deficiency in insulin discharge, insulin attainment, or equally [ 1 ]. Pancreas, positioned aft
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Interactions Between Antidiabetic Drugs And Herbs: An Overview Of Mechanisms Of Action And Clinical Implications

Abstract Diabetes is a complex condition with a variety of causes and pathophysiologies. The current single target approach has not provided ideal clinical outcomes for the treatment of the disease and its complications. Herbal medicine has been used for the management of various diseases such as diabetes over centuries. Many diabetic patients are known to use herbal medicines with antidiabetic properties in addition to their mainstream treatments, which may present both a benefit as well as potential risk to effective management of their disease. In this review we evaluate the clinical and experimental literature on herb–drug interactions in the treatment of diabetes. Pharmacokinetic and pharmacodynamic interactions between drugs and herbs are discussed, and some commonly used herbs which can interact with antidiabetic drugs summarised. Herb–drug interactions can be a double-edged sword presenting both risks (adverse drug events) and benefits (through enhancement). There is a general lack of data on herb–drug interactions. As such, more rigorous scientific research is urgently needed to guide clinical practice as well as to safeguard the wellbeing of diabetes patients. Keywords Herb–drug interactionsAntidiabetic drugsAntidiabetic herbsPharmacokinetic interactionPharmacodynamics interactionSynergism Background Diabetes mellitus refers to a group of chronic metabolic diseases which are generally characterised by hyperglycaemia, which eventually leads to damage of multiple body systems. There are two types of diabetes, type 1 (T1DM) and type 2 (T2DM) diabetes mellitus. T1DM is referred as insulin-dependent diabetes mellitus (IDDM) and is caused by the impaired production of insulin. T2DM, however, is commonly associated with the inability of cells to respond to in
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Traditional Indian Medicines Used For The Management Of Diabetes Mellitus

Traditional Indian Medicines Used for the Management of Diabetes Mellitus 1Department of Biochemistry, University of Allahabad, Allahabad 211002, India 2Centre of Food Technology, University of Allahabad, Allahabad 211002, India Received 7 April 2013; Accepted 16 May 2013 Copyright 2013 Syed Ibrahim Rizvi and Neetu Mishra. This is an open access article distributed under the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Plants have always been a source of drugs for humans since time immemorial. The Indian traditional system of medicine is replete with the use of plants for the management of diabetic conditions. According to the World Health Organization, up to 90% of population in developing countries use plants and its products as traditional medicine for primary health care. There are about 800 plants which have been reported to show antidiabetic potential. The present review is aimed at providing in-depth information about the antidiabetic potential and bioactive compounds present in Ficus religiosa, Pterocarpus marsupium, Gymnema sylvestre, Allium sativum, Eugenia jambolana, Momordica charantia, and Trigonella foenum-graecum. The review provides a starting point for future studies aimed at isolation, purification, and characterization of bioactive antidiabetic compounds present in these plants. Diabetes mellitus is a growing problem worldwide entailing enormous financial burden and medical care policy issues [ 1 ]. According to International Diabetes Federation (IDF), the number of individuals with diabetes in 2011 crossed 366 million, with an estimated 4.6 million deaths each year [ 2 ]. The Indian subcontinent has emerged as the capital of this dia
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Indian Herbs And Herbal Drugs Used For The Treatment Of Diabetes

Go to: Diabetes and Significance Diabetes is a chronic disorder of carbohydrate, fat and protein metabolism characterized by increased fasting and post prandial blood sugar levels. The global prevalence of diabetes is estimated to increase, from 4% in 1995 to 5.4% by the year 2025. WHO has predicted that the major burden will occur in developing countries. Studies conducted in India in the last decade have highlighted that not only is the prevalence of diabetes high but also that it is increasing rapidly in the urban population [4]. It is estimated that there are approximately 33 million adults with diabetes in India. This number is likely to increase to 57.2 million by the year 2025. Diabetes mellitus is a complex metabolic disorder resulting from either insulin insufficiency or insulin dysfunction. Type I diabetes (insulin dependent) is caused due to insulin insufficiency because of lack of functional beta cells. Patients suffering from this are therefore totally dependent on exogenous source of insulin while patients suffering from Type II diabetes (insulin independent) are unable to respond to insulin and can be treated with dietary changes, exercise and medication. Type II diabetes is the more common form of diabetes constituting 90% of the diabetic population. Symptoms for both diabetic conditions may include: (i) high levels of sugar in the blood; (ii) unusual thirst; (iii) frequent urination; (iv) extreme hunger and loss of weight; (v) blurred vision; (vi) nausea and vomiting; (vii) extreme weakness and tiredness; (viii) irritability, mood changes etc. Though pathophysiology of diabetes remains to be fully understood, experimental evidences suggest the involvement of free radicals in the pathogenesis of diabetes [5] and more importantly in the development of dia
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Anti Diabetic Medicinal Plants

Diabetes is a world leading disease, 7th leading cause of death, percentage of people suffering from diabetes throughout the world was 9.3% which may increase by the end of 2020. Diabetes is a long-term condition that causes high blood sugar levels over a prolonged period. Diabetes is due to either the pancreas not producing enough insulin or the cells of the body not responding properly to the insulin produced.[ 1 - 4 ] Genetic makeup, Family history, Ethnicity, Health, Life style and Environmental factors, during pregnancy Diabetic dermadromes, Polyuria, Polydipsia, Polyphagia, Fatigue, causing problems in the Eyes, Kidneys, Feet and Nerves , Macrovascular and Microvascular complications Type 1 Diabetes- Insulin-dependent diabetes, juvenile diabetes, or early-onset diabetes. Type 2 Diabetes- Non insulin-dependent diabetes Gestational Diabetes - Affects females during pregnancy Life style modification: Diet, Exercise, Stress management, Increased social support Synthetic Drugs: By using Synthetic Drugs people will suffer from serious side effects Few examples of Synthetic Drugs: Sulfonylureas , Biguanides/Metformin, Alpha-glucosidase inhibitors, Thiazolidinediones , Meglitinides Homeopathy: Homeopathy have a long history of chronic ailments, and hence the treatment takes time. homeopathy is slow acting Herbal medicines: The natural medications with antidiabetic activity are widely formulated because they are better compatibility with human body, easily available and less side effects when compared with the synthetic antidiabetic medications. Antidiabetic herbal formulations are considered to be more effective for treatment of diabetes. More number of plant and plant products have been scientifically tested and reported to posses anti diabetic activity [ 26 - 35 ] Exam
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A Review On: Potential Antidiabetic Herbal Medicines | International Journal Of Pharmaceutical Sciences And Research

Home A REVIEW ON: POTENTIAL ANTIDIABETIC HERBAL MEDICINES A REVIEW ON: POTENTIAL ANTIDIABETIC HERBAL MEDICINES Received on 05 September, 2013; received in revised form, 30 October, 2013; accepted,04 January, 2014; published01 February, 2014 A REVIEW ON: POTENTIAL ANTIDIABETIC HERBAL MEDICINES Praful A. Talaviya*1, Shaival K. Rao 2, Bhavesh M. Vyas 3, Shashipal P. Indoria 4, Rakesh K. Suman 4 and Vishal P. Suvagiya 5 Faculty of Pharmaceutical Sciences, Pacific University 1, Udaipur, Rajasthan, India Department of Pharmacognosy, C.U. Shah College of Pharmacy & Research 2, Surendranagar, Gujarat, India Department of Pharmacology, AMC-MET Medical College 3, Ahmedabad, Gujarat, India Department of Pharmaceutics, RKDF College of Pharmacy 4, Bhopal, Madhya Pradesh, India Department of Pharmacology, Gyanvihar University 5, Jaipur, Rajasthan, India Diabetes mellitus (DM) is a metabolic disorder of the endocrine system. This frightful disease is found in all parts of the world and is becoming a serious threat to healthcare providers. Nowadays DM is a most spreading disease in the world. In rapidly growing world a number of treatment options are available for treatment of DM. Long term use of allopathic medicinal agents may cause unwanted side effects, resulting uncontrolled blood sugar as well as complications of DM, also DM is highly prone to different types of microorganism and it will affect immune system of body. The use of herbal medicine for the prevention and treatment of DM has been in practice since ancient time. Medicinal plants as a traditional medicine is being used by about 60% of the worlds population and India is major contributor to produced herbal medicines. Generally it is believed that the risk associated with herbal medicine is very less, but reports on serio
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Antidiabetic Herbal Drugs A Review

Traditional medicines derived from medicinal plants are used by about 60% of the world's population. This review focuses on Indian herbal drugs and plants used in the treatment of diabetes, especially in India. Diabetes is an important human ailment afflicting many from various walks of life in different countries. In India it is proving to be a major health problem, especially in the urban areas. Though there are various approaches to reduce the ill effects of diabetes and its secondary complications, herbal formulations are preferred due to lesser side effects and low cost. A list of medicinal plants with proven antidiabetic and related beneficial effects and of herbal drugs used in treatment of diabetes is compiled. These include Allium sativum, Eugenia jambolana, Momordica charantia, Ocimum sanctum, Phyllanthus amarus, Pterocarpus marsupium, Tinospora cordifolia, C. indica, Helicteres isora, Stevia rebaudiana, Gymnema sylvestre, Enicostemma littorale Blume. Do you want to read the rest of this article? ... This connotes that SE extract may be capable of providing some degree of delay in the onset of diabetes. Improved glucose tolerance is associated with the availability and functionality of plasma insulin . This is evident in the present study in which treatment of rats with the extract significantly improved the level of insulin both in the serum and pancreas. ...
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Indian Herbs And Herbal Drugs Used For The Treatment Of Diabetes

Biology and Health Sciences Division, Bhabha Atomic Research Centre, Mumbai 400085, India Received 19 September, 2006; Accepted 6 December, 2006 Summary Traditional Medicines derived from medicinal plants are used by about 60% of the worlds population. This review focuses on Indian Herbal drugs and plants used in the treatment of diabetes, especially in India. Diabetes is an important human ailment afflicting many from various walks of life in different countries. In India it is proving to be a major health problem, especially in the urban areas. Though there are various approaches to reduce the ill effects of diabetes and its secondary complications, herbal formulations are preferred due to lesser side effects and low cost. A list of medicinal plants with proven antidiabetic and related beneficial effects and of herbal drugs used in treatment of diabetes is compiled. These include, Allium sativum, Eugenia jambolana, Momordica charantia Ocimum sanctum, Phyllanthus amarus, One of the etiologic factors implicated in the development of diabetes and its complications is the damage induced by free radicals and hence an antidiabetic compound with antioxidant properties would be more beneficial. Therefore information on antioxidant effects of these Key Words: medicinal plant, India, antidiabetic, antioxidant, diabetes In the last few years there has been an exponential growth in the field of herbal medicine and these drugs are gaining popularity both in developing and developed countries because of their natural origin and less side effects. Many traditional medicines in use are derived from medicinal plants, traditionally used for over 1000 years named rasayana are present in herbal preparations of Indian traditional health care systems [2]. In Indian systems of medicine mos
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