Major operators who operate buses from Bangalore to Mangalore are Durgamba Motors, Sugama Tourist Bangalore, VRL Travels having the maximum number of services. The first busis around 07:30 PM and last bus is at 10:50 PM. The lowest Bangalore to Mangalore bus fare being Rs.550 and the highest being Rs.1550 depending on the type of bus. Non A/C Sleeper (2+1), Volvo A/C Multi-Axle, Volvo A/C Multi-Axle Semisleeper, A/C Sleeper, Non A/C Seater buses are available.

All vehicles, other than heavy goods and multi-axle vehicles from Mangalore to Hassan and Bangalore, can take the Charmadi Ghat route to reach Mudigere and reach Hassan either via Belur or via Jannapura, Hanabal, Anemahal and Sakleshpur. These routes would be longer by 10 km and 12 km, respectively.

Heavy goods and multi-axle vehicles have to take the State Highway 88 from Mani and pass through Madikeri to reach either Hassan or Bangalore. Vehicles have to operate via Madikeri, Hunsur, K.R. Nagar and Holenarasipur to reach Hassan (309 km). Those bound for Bangalore can directly proceed to Ilavala and join Mysore-Bangalore State Highway near Srirangapatna (390 km). Heavy goods and multi-axle vehicles could take the Balebare Ghat, that is, the Haladi/Kundapura, Hosangadi, Mastikatte, Hosanagar and Shimoga route to reach Bangalore (469 km).

Light motor vehicles and commercial vehicles from Udupi have two more options to reach Bangalore. They can take the Agumbe Ghat route and proceed via Thirthahalli and Shimoga (424 km) or the Mala Ghat (after Karkala) and reach Bangalore via Kudremukh, Kalasa, Mudigere and Hassan (420 km).

The Shiradi Ghat stretch on the Mangalore-Bangalore National Highway is blocked for all vehicles for about six months from December 1, 2014. The 47-km road will be upgraded for Rs 155.18 crore. The other routes are NH275, Mani-Puttur-Sullia, Madikeri-Mysore (turn near Ilawala), Srirangapatna, Bangalore, and NH 234 Charmadi-Chikmagalur-Hassan-Bangalore. One more route suggested is NH206 via Udupi-Kundapur-Hulikal Ghat-Shimoga-Tumkur Road.