PURPOSE The purposes of this study were to evaluate the effectiveness of a 12-week virtual reality exercise program designed around the Nintendo Wii(Wii), in improving Alzheimer’s dementia patients’ memories. METHODS 30 Alzheimer dementia patients were randomly assigned in to the experimental group(n=15) and control group(n=15). All subjects performed a routine cognitive therapy and, besides, experimental group performed three 40-minute Wii-exercise intervention sessions per week, for 12 weeks. Before and after the Wii intervention, subjects’ cognitive functions were evaluated using the Cognitive Assessment Reference Diagnosis System (CARDS) and Mini-Mental State Examination-Korea (MMSE-K) test. Statistical significance was tested within and between each group before and after treatment by Wilcoxon signed rank test and Mann-Whitney U test. RESULTS Among the CARDS scores of the subjects who received Wii-exercise, the scores of the delayed 10-word list, delayed 10-object list, recognition 10-object, and recent memory significantly increased after intervention compared to those before intervention(pCONCLUSIONS These suggest that a virtual reality exercise program using the Wii-game, is effective in delaying memory deterioration and improving cognitive function of elderly people with Alzheimer dementia.