..This clinical trial evaluated the long-term (1 year) safety and efficacy of duloxetine, a dual reuptake inhibitor of serotonin and norepinephrine, in patients with DSM-IV major depressive disorder...

Duloxetine in treatment of anxiety symptoms associated with depression

David L DunnerDepartment of Psychiatry and Behavioral Sciences, University of Washington Center for Anxiety and Depression, Seattle, WA, USADepress Anxiety 18:53-61. 2003

..Efficacy in these three key symptom domains may in turn explain the high probabilities of remission (43-57%) observed in these studies...

The tyramine pressor test may have limited sensitivity, especially in the presence of dual serotonin/norepinephrine uptake inhibition