239764
Cycloheximide, High Purity - CAS 66-81-9 - Calbiochem

Cycloheximide, High Purity, CAS 66-81-9, is an antifungal antibiotic that inhibits protein synthesis in eukaryotes. Interacts directly with a translocase and interferes with the translocation step.

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MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Cycloheximide, High Purity, CAS 66-81-9, is an antifungal antibiotic that inhibits protein synthesis in eukaryotes. Interacts directly with a translocase and interferes with the translocation step.

Biological Information

Primary Target

hFKBP12

Primary Target K<sub>i</sub>

3.4 µM

Purity

≥98% by HPLC

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

RTECS

MA4375000

Safety Information

R Phrase

R: 28-40-51/53-61

Very toxic if swallowed.Limited evidence of a carcinogenic effect.Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.May cause harm to the unborn child.

S Phrase

S: 45-53-61

In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).Avoid exposure - obtain special instructions before use.Avoid release to the environment. Refer to special instructions/safety data sheet.

Product Usage Statements

Storage and Shipping Information

Ship Code

Ambient Temperature Only

Toxicity

Highly Toxic & Carcinogenic / Teratogenic

Hazardous Materials Attention:

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Storage

+15°C to +30°C

Do not freeze

Ok to freeze

Special Instructions

Following reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. Stock solutions are stable for up to 6 weeks at 4°C, pH 3-5.

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision

29-April-2008 RFH

Description

Antifungal antibiotic that does not inhibit several species of pathogenic bacteria at 100 µg/ml. Inhibits protein synthesis in eukaryotes but not in prokaryotes. Interacts directly with the translocase enzyme, interfering with the translocation step. Inhibits cell-free protein synthesis in eukaryotes. Competitively inhibits hFkBP12 (Ki = 3.4 µM). Triggers apoptosis in HL-60 cells, T-cell hybridomas, Burkitt's lymphoma cells, and a variety of other cell types, including rodent macrophages. Inhibits DNA cleavage in rat thymocytes treated with thapsigargin, methylprednisolone, and ionomycin. Rapidly destroyed in alkaline solutions.

Form

White solid

CAS number

66-81-9

RTECS

MA4375000

Chemical formula

C₁₅H₂₃NO₄

Structure formula

Purity

≥98% by HPLC

Solubility

Chloroform, Ethanol, and Methanol

Storage

+15°C to +30°C

Do Not Freeze

Ok to freeze

Special Instructions

Following reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. Stock solutions are stable for up to 6 weeks at 4°C, pH 3-5.