Mimi is Mr. Bell's (and then later, Mr. Wick's) assistant/secretary and the main antagonist of the series. She is an overweight woman, who wears a lot of make-up, yet has very high but unstable self-esteem. (As an in-joke, Mimi's mother, Mother Bobeck, was played by Tammy Faye Bakker.) Mimi is Drew's arch-nemesis; she vowed to make Drew's life a living hell after Drew denied her a job based on her makeup. Mimi's pranks have included gluing Drew's hand to a pornographic magazine, covering Drew's desk with garbage, and eventually sending Drew to China while he is unconscious. She is also known for calling him "Pig" and "Doughboy."

Her character can be seen as an attack on societal norms of beauty. Mimi's past has a lot of connections to the world of music; she often talks about being a roadie for Foghat and was married to Eddie Money for two weeks after appearing at his first concert. Additionally, she admits to sleeping with both Joe Walsh and Peter Frampton. Frampton still carries a torch for Mimi; he has a tattoo of her likeness on his chest. Later on, Mimi becomes more of a friend to Drew, after they agree to put their feud on hold while Mimi dates/marries Steve (John Carroll Lynch) and a good, if unconventional, mother to Gus. Early in the series, it was revealed that Mimi was of Polish ancestry, and inherited the title of Duchess of Kraków after her aunt died. However, the episode with this content received plenty of complaint from the Polish community, and all mention of Mimi's heritage has been removed from the show (with alternative footage placed over these bits in syndication).