Has anyone tried cytotoxic drugs for rheumatoid arthritis? How did you find them?

I have rheumatoid arthritis & have been on celebrex,daypro,mobic,naproxen,relafen &voltaren I had no relief w/any of these,so he wants me to start a regimen of cytotxic drugs;what i would like to know is, does anyone have personal experience w/ these & what they consider the safest?