The logline is being kept under tight wraps, although storyline generally revolves around the ease with which men and women become sexually involved, but have a far more difficult time establishing emotional bonds.

Reitman’s directing credits include the “Ghostbuster” franchise — he’s readying “Ghostbusters 3″ for Sony Pictures — “Stripes” and “Dave.” He’s become a prolific producer via Montecito, and received his first Academy Award nomination for producing Paramount’s “Up in the Air,” directed by his son, Jason Reitman.

Portman is in theaters this fall with David Gordon Green’s adventure-comedy “Your Highness,” from Universal. She recently wrapped production on Darren Aronofsky’s “Black Swan,” and also is set to star in Kenneth Branagh’s “Thor.”

Kutcher was most recently seen in Gary Marshall’s “Valentine’s Day,” and will next be seen in Robert Luketic’s action-comedy “Killers” opposite Katherine Heigl. Lionsgate opens “Killers” June 4.