Venus Williams is no longer the player she once was, on account of the passage of time and the day-to-day ups and downs of an energy-sapping condition.

At age 35, 21 years removed from her first professional tournament, Williams still possesses a dangerous serve, along with the muscle memory that comes with seven Grand Slam singles titles, five at Wimbledon.

And so while it is her younger sister Serena who is ranked No. 1, has 20 major titles and owns a 23-match Grand Slam winning streak as of Wednesday, the elder Williams is still in the draw at the All England Club, too — and the siblings are closing in on what would be their 26th all-in-the-family matchup on tour.

“She probably comes back here and, you know, I think, she almost feels like this is home,” said David Witt, Venus’ coach. “When you have confidence, you have everything. That’s with any sport. And I guess when she gets here, it’s a confidence thing.”

On the hottest day on record in Wimbledon history, with the temperature topping 95 degrees (35 degrees Celsius) — and a terrific day for American women — both Williams sisters won second-round matches: 16th-seeded Venus beat 95th-ranked Yulia Putintseva of Kazakhstan 7-6 (5), 6-4, while top-seeded Serena defeated 93rd-ranked Timea Babos of Hungary 6-4, 6-1.

Two more wins, and the siblings will meet in the fourth round.

“She poses a big threat for me,” Serena said about Venus.

They pulled out of doubles on Tuesday, citing “soreness” for Serena, who wants to focus on her pursuit of a fourth consecutive Grand Slam title.

Four other women from the U.S. won Wednesday, including two real surprises: 158th-ranked qualifier Bethanie Mattek-Sands eliminated No. 7 Ana Ivanovic, the 2009 French Open champion, 6-3, 6-4; and 47th-ranked CoCo Vandeweghe, the niece of former NBA player and executive Kiki, beat No. 11 Karolina Pliskova 7-6 (5), 6-4.

Also advancing: No. 21 Madison Keys, who finished off a match suspended because of darkness at 2-all in the third set a night earlier, and Sloane Stephens.

A pair of U.S. men moved on, too: No. 17 John Isner and 105th-ranked wild-card entry Denis Kudla, who followed up his victory over No. 28 Pablo Cuevas by getting past 18-year-old Alexander Zverev.

Spectators fanned themselves in the stands and used everything from hats to umbrellas to towels for shade. A ball boy collapsed during Isner’s match and was taken away on a stretcher. One player, No. 27 Bernard Tomic of Australia, said he felt dizzy during his victory. Others, including Mattek-Sands, wrapped towels filled with ice around their necks during changeovers.

“It’s definitely hot, but nothing crazy. We have played in worse. I think it’s just surprising because it's happening in England, where it usually doesn’t,” Keys said. “We have played through much worse.”