The only other mods I have installed are:
Recount
Omen
Deadly Boss Mods

It is the first time I see this, and the only thing that has changes is the download of the hotfix today. I have not manually modified anything else. Also I have no skins installed for nUI so I am not sure what it is missing.. The whole lower center part of the UI where the map and my toon/target is located is all black. It's like nbone of the frames are drawn.