Italian Family Feels No Pain

Scientists have identified a mysterious genetic mutation that effectively negates the sensation of pain, enabling people with the rare anomaly to persevere effortlessly through extreme physical discomfort.

The gene variant – identified in an Italian family who feels almost no pain even when seriously injured…

[ references at end of post ]

Unfortunately a lot of individuals feel no pain when God attempts to bless them with repentance.1When God raised up his servant, he sent him first to you to bless you by turning each of you from your wicked ways.” (Acts 3:26)

Ah, sinful nation, a people loaded with guilt, a brood of evildoers, children given to corruption!

They have forsaken the Lord ; they have spurned the Holy One of Israel and turned their backs on him. Why should you be beaten anymore?

Why do you persist in rebellion? Your whole head is injured, your whole heart afflicted. From the sole of your foot to the top of your head there is no soundness- only wounds and welts and open sores, not cleansed or bandaged or soothed with oil. (Isaiah 1:4-6)

Bonus:

Of course many feel the pain of God’s disciple but fail to be trainedby it.

In short, their discipline was waste of time and resulted in ever deeper, though often masked, sins.

No discipline seems pleasant at the time, but painful. Later on, however, it produces a harvest of righteousness and peace for those who have been trained by it. (Hebrews 12:11)

Article Reference

(sciencealert.com)—That family, the Marsilis, go about their daily lives with something much like a real-life superpower, thanks to a rare genetic point mutation spanning at least three generations.

The mutation means they feel little or no pain from things like burns or broken bones, to the point where they don’t always actually realise when they’ve been hurt.

“Sometimes they feel pain in the initial break but it goes away very quickly,” Cox told New Scientist.

“For example, [52-year-old] Letizia broke her shoulder while skiing, but then kept skiing for the rest of the day and drove home. She didn’t get it checked out until the next day.”

The variant shared by the family was isolated in the Marsilis’ DNA from blood samples, and is located in a gene called ZFHX2.

While it’s not entirely clear how the mutation works, the team hypothesises that the variant disrupts how ZFHX2 regulates other genes that have been linked to pain signalling.

That disruption gives the Marsilis what’s known as congenital insensitivity to pain, but their phenotype is so remarkable the researchers have named a whole sub-type of the condition, ‘Marsili syndrome’, after the family.

In the Marsilis’ case, the blessing can also be a curse, as the failure to accurately interpret what pain represents can mean they’re not aware of serious injuries that might need medical attention.

“He rarely stays on the ground, even when he is knocked down. However, he has fragility at the ankles and he often suffers distortions, which are micro fractures,” Letizia Marsili told the BBC.

“In fact, recently X-rays have shown that he has lots of micro fractures in both ankles.”

Other family members have experienced similar problems, with Letizia’s 78-year-old mother experiencing fractures that are only much later diagnosed, meaning they harden naturally but do not heal properly.

The mutation also affects their ability to detect extreme temperatures, putting them at greater risk of burning themselves, or failing to register things like ice water.

Despite the risks inherent in feeling no pain, the family seems grateful to be missing out on what is a source of misery for so many others.

“From day to day we live a very normal life, perhaps better than the rest of the population, because we very rarely get unwell and we hardly feel any pain,” Letizia told the BBC.

“However, in truth, we do feel pain, the perception of pain, but this only lasts for a few seconds.”

Once the researchers isolated the ZFHX2 mutation by way of exome sequencing, the team used animal experiments to see how the variant affects pain processing in mice.

Animals bred to not have the gene at all showed reduced pain sensitivity when pressure was applied to their tails, but were still receptive to high heat.

When other mice were bred to possess the ZFHX2 mutation, they exhibited the same low sensitivity to high heat that the Marsilis have – something the team is hopeful may provide new directions into treatments for millions who live with chronic pain daily.

“By identifying this mutation and clarifying that it contributes to the family’s pain insensitivity, we have opened up a whole new route to drug discovery for pain relief,” says one of the researchers, Anna Maria Aloisi from the University of Siena in Italy.

Your rights? A footnote for now - but slowly being trampled underfoot.

And I should know.

Note the footnote - the warning that the Seattle Police will come after churches, groups anything that is "collective" against their beliefs.

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Governor Jay Inslee Beating Up Those Who Oppose His Belief About Sex

Governor Jay Inslee corrupts the courts by walking Judge Mary Yu up the State of Washington courthouse steps.

Such lawless abuse of the legal system to bully one's beliefs is the hallmark of corruption. Think putting blacks in jail in the deep down south of the United States and you will understand clearly what Governor Jay Inslee has done to the justice system.

Later Governor Jay Inslee would declare an embargo, an act of war, against the State of Indinia for their beliefs.

: a way of organizing a society in which a government ruled by a dictator controls the lives of the people and in which people are not allowed to disagree with the government

: gay agenda, environmental wacko, family destruction

: very harsh control or authority

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King County Court Corruption and Hate Crime Endorsement

www.hardtruth.us

Hate Crime Endorsement

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Note the right way to holiness.

Set up road signs; put up guideposts. Take note of the highway, the road that you take. (Jeremiah 31:21)

Note those who are on the right road of holiness.

Join with others in following my example, brothers, and take note of those who live according to the pattern we gave you. (Philippians 3:17)

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Since you ignored all my advice and would not accept my rebuke, I in turn will laugh at your disaster; I will mock when calamity overtakes you- ~God, (Proverbs 1:25-26)

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I applied my heart to what I observed and learned a lesson from what I saw: (Proverbs 24:32)

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The words of the wise are like goads, their collected sayings like firmly embedded nails-given by one Shepherd. Be warned, my son, of anything in addition to them. Of making many books there is no end, and much study wearies the body. (Ecclesiastes 12:11-12)

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If you want to keep reading the reference article is on enumclaw.com - opinion unto righteousness.

Instruct a wise man and he will be wiser still; teach a righteous man and he will add to his learning.

(Proverbs 9:9)

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Since they hated knowledge and did not choose to fear the Lord , since they would not accept my advice and spurned my rebuke, they will eat the fruit of their ways and be filled with the fruit of their schemes. For the waywardness of the simple will kill them, and the complacency of fools will destroy them; but whoever listens to me will live in safety and be at ease, without fear of harm. (Proverbs 1:29-33)

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To whom can I speak and give warning? Who will listen to me? Their ears are closed so they cannot hear. The word of the Lord is offensive to them; they find no pleasure in it. (Jeremiah 6:10)

n 1998, Dr. Phillip Esplin, a forensic psychologist for the National Institutes of Health's Child Witness Project said that "Wenatchee may be the worst example ever of mental health services being abused by a state.

The man who loves his life will lose it, while the man who hates his life in this world will keep it for eternal life. (John 12:25)

So Jesus said, "When you have lifted up the Son of Man, then you will know that I am the one I claim to be and that I do nothing on my own but speak just what the Father has taught me." (John 8:28)

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Shamefully Treated By Authorities

On the contrary, after we had previously suffered and been outrageously treated in Enumclaw... (1 Thessalonians 2:2)

Sound Doctrine Church is no longer.

The preacher was Timothy Williams who formally was allowed to live in Enumclaw Washington until authorities ran him out.

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I can’t believe …still being told that being gay is wrong. so says Jeremy Jordan and begins to incite hatred towards those who oppose his idea of sex.Really, it is kinda surprising that Jeremy Jordon is still in favor of black individuals being slaves today. Clearly, according to Mr. Jordon since the Supreme Court has ruled that same-sex individuals may marry, and since the Supreme Court ruled that a black man was property, such is truth. Mr. Jordon confuses the opinion of judges with truth – and seldom do the two meet.

Prosecutor David Seaver told the Court to keep secret the activities of Enumclaw Detective Grant McCall.

Naturally the court was eager to keep things in the darkness.

Or, the lawless excuse that the right to confront an accuser could not happen, according to Judge Lori K. Smith's order, because "no adult could be found."

Judge Lori K. Smith not only helped King County Prosecutors, but such Prosecutors knew they could ignore, rebel and reject her court orders because Prosecutor Dan Satterberg has flourished lawlessness in the name of The Law.

http://hardtruth.us/seaver-police-secrets/

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Prosecutor Mark Larson, of King County Washington produced not 1-single-piece of evidence a crime had been committed, yet, had the ridiculous gall to tell a jury just to say "So what" to evidence - Honorable Judge Lori K. Smith sitting by. The video proof can be found at www.hardtruth.us

Cultural Christianity is a form of religion that simply believes Jesus died to maintain one's county, lifestyle and culture.

Cross-carrying Christians hate their own will, denying self while picking up a cross in order to follow Jesus.

They are the only honest Christians.

The man who loves his life will lose it, while the man who hates his life in this world will keep it for eternal life. (John 12:25)

(enumclaw.com)

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The gatekeepers shouted the news, and it was reported within the palace. (2 Kings 7:11)

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Have complaint, Governor says file it with the WSBA. Have a court complaint the Supreme Court says file it with the WSBA ...get it?

Washington State Bar Association in complete corruption of conflict of interest has designed bureaucracy to block any attempts at reform. The Washington State Supreme Court, the Governor's Office, Prosecutors and Judges all have tie-ins and systems in place to protect their power base. This is why Governor Jay Inslee will tell you to file complaints with Washington State Bar Association and the Washington Supreme Courts has "instructed" the WSBA to police the Washington State Courts. This is exactly way the corruption continues to increase.

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"It takes only passing familiarity with recent news..." King County Prosecutor David Seaver, Washington State before Appeals Judges.

Those who were standing near Paul said, "You dare to insult God's high priest?" Paul replied, "Brothers, I did not realize that he was the high priest; for it is written: 'Do not speak evil about the ruler of your people.' " (Acts 23:4-5)