A delayed-type hypersensitivity reaction to infectious agents, medications, or malignancies, or in the setting of autoimmune disorders, presenting as a subcutaneous panniculitis

Clinical pattern of multiple, bilateral, erythematous, tender subcutaneous nodules that undergo a characteristic pattern of color changes, similar to that seen in bruises. Unlike erythema induratum, the lesions of erythema nodosum do not typically ulcerate.

Occurs most commonly on the shins, less commonly on the thighs and forearms

May be accompanied by fever and arthralgias

Often idiopathic but may be associated with a number of clinical entities

Usually remits spontaneously in weeks to months without scarring or atrophy

Synonym(s): Dermatitis contusiformis

Pregnancy Considerations

May have repeat outbreaks during pregnancy

Epidemiology

Incidence

1-5/100,000

Predominant age: 20–30 years

Predominant sex: Female > Male (3:1).

Prevalence

Varies geographically depending on the prevalence of disorders associated with erythema nodosum

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