{"gene_symbol":"ACACA","mgp_id":"MGP000016","gene_id":"31","gene_name":"acetyl-CoA carboxylase alpha","gene_synonyms":"ACC; ACAC; ACC1; ACCA; ACACAD;","alt_names":"acetyl-CoA carboxylase 1; ACC-alpha; acetyl-Coenzyme A carboxylase alpha;","chromosome":"17","map_location":"17q21","summary":"Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation\/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]","taxid":"9606","species":"Human","species_long":"Homo sapiens"}