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Research Interests

My research has been focused on the basic biology of adeno-associated virus (AAV) and its application as a gene transfer vector for basic research and human gene therapy.

On AAV vector biology, my lab is working on two issues that are critical for the gene therapy field. One is AAV integration frequency, which has implications for AAV vector safety and its feasibility as a vector for stem cells. The other project is to understand AAV transduction mechanisms through tracking the status of AAV DNA genomes.

In addition, my lab is developing new strategies to engineer and deliver coagulation factors using AAV vectors for gene therapy of hemophilia A. Further applications of AAV vectors are also being explored

Education, Training & Credentials

Educational Background

PhD, Genetics and Molecular Biology, University of North Carolina, 1996