Scientists at the National Institute of Neurological Disorders and Stroke (NINDS) seek persons with Tourette syndrome (TS)
for a research study of sensory symptoms such as clothing discomfort and premonitory urge.

TS is a neurological disorder that causes people to have uncontrolled movements, called “tics.” A tic can also be vocal,
like a cough or a bark, or even as severe as a string of bad words. In either case, before a person with TS actually has
a tic, they often feel the urge to tic. This is similar to feeling an urge to scratch an itch. Sometimes people with TS
experience other sensations, such as a tickling feeling on the skin or a discomfort with certain clothing items. In this
study, NINDS scientists will observe brain activity during the time of these sensations and how it may differ in people who
have TS and people who do not have TS.

Participants in the study will undergo a non-invasive procedure called a magnetoencephalogram (MEG) which records the magnetic
field changes produced by brain activity.

Eligible persons should have a diagnosis of TS and be between the ages of 14 and 65. Persons who have metal objects implanted
in their bodies or have been diagnosed with certain neuropsychiatric disorders other than TS, or who are pregnant or taking
certain medications, may not be eligible.

The one-day outpatient study will take place at the National Institutes of Health (NIH)
ClinicalCenter, and require 5.5 hours of time. There is no cost for participation or any tests associated with the research. Travel compensation
will be provided for participants.