Abstract

Convection enhanced delivery (CED) is a promising alternative to systemic administration for bypassing the blood brain barrier, because of which most anticancer drugs are blocked in the blood circulatory system instead of concentrating in the targeted tumour tissue. As drugs are injected directly into the tumour extracellular space during CED treatment, fast drug eliminationdue to physical degradation and metabolism significantly hinders effective drug penetration into large tumours, which represents one of the main limitations of CED. If drugs are encapsulated within nanoparticles which are harder for the body to eliminate, drugs can be released in a more controllable manner over time, thereby improving the potential for treatment. The present study aims to examine the impact of tumour and nanoparticle transport properties on the delivery outcomes, with the aim to optimise this drug delivery system.

abstract = "Convection enhanced delivery (CED) is a promising alternative to systemic administration for bypassing the blood brain barrier, because of which most anticancer drugs are blocked in the blood circulatory system instead of concentrating in the targeted tumour tissue. As drugs are injected directly into the tumour extracellular space during CED treatment, fast drug eliminationdue to physical degradation and metabolism significantly hinders effective drug penetration into large tumours, which represents one of the main limitations of CED. If drugs are encapsulated within nanoparticles which are harder for the body to eliminate, drugs can be released in a more controllable manner over time, thereby improving the potential for treatment. The present study aims to examine the impact of tumour and nanoparticle transport properties on the delivery outcomes, with the aim to optimise this drug delivery system.",

author = "Wenbo Zhan and Baena, {Ferdinando Rodriguez y}",

note = "We are grateful to EDEN2020, a project funded by European Union’s H2020 Research and Innovation Programme under grant agreement NO. 688279.",

N1 - We are grateful to EDEN2020, a project funded by European Union’s H2020 Research and Innovation Programme under grant agreement NO. 688279.

PY - 2018

Y1 - 2018

N2 - Convection enhanced delivery (CED) is a promising alternative to systemic administration for bypassing the blood brain barrier, because of which most anticancer drugs are blocked in the blood circulatory system instead of concentrating in the targeted tumour tissue. As drugs are injected directly into the tumour extracellular space during CED treatment, fast drug eliminationdue to physical degradation and metabolism significantly hinders effective drug penetration into large tumours, which represents one of the main limitations of CED. If drugs are encapsulated within nanoparticles which are harder for the body to eliminate, drugs can be released in a more controllable manner over time, thereby improving the potential for treatment. The present study aims to examine the impact of tumour and nanoparticle transport properties on the delivery outcomes, with the aim to optimise this drug delivery system.

AB - Convection enhanced delivery (CED) is a promising alternative to systemic administration for bypassing the blood brain barrier, because of which most anticancer drugs are blocked in the blood circulatory system instead of concentrating in the targeted tumour tissue. As drugs are injected directly into the tumour extracellular space during CED treatment, fast drug eliminationdue to physical degradation and metabolism significantly hinders effective drug penetration into large tumours, which represents one of the main limitations of CED. If drugs are encapsulated within nanoparticles which are harder for the body to eliminate, drugs can be released in a more controllable manner over time, thereby improving the potential for treatment. The present study aims to examine the impact of tumour and nanoparticle transport properties on the delivery outcomes, with the aim to optimise this drug delivery system.