About three years ago we commenced using carbohydrate tolerance tests as a routine procedure in all cases in which there might exist a functional disturbance of any of the ductless glands. At that time we thought that if the test were carefully worked out in a large enough series of cases, some diagnostic importance might be attached to it. From a knowledge of the work of previous investigators, we realized that sugar tolerance could never be a specific test, for at least in the metabolism of glucose many organs play a rôle. Von Noorden's1 conception of the liver as the central figure in a circle of pressor and depressor influences seemed a logical working basis — hypophysis, thyroid and adrenal being pressors, and pancreas the depressor of carbohydrate metabolism. Clinical evidence was forthcoming to show that states of hyperacidity of the pressor organs and hypo-activity of the