Summariesfor PTGS2 gene

Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin

biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive

PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene

encodes the inducible isozyme. It is regulated by specific stimulatory events, suggesting that it is responsible

for the prostanoid biosynthesis involved in inflammation and mitogenesis. (provided by RefSeq, Feb 2009)

GeneCards Summary for PTGS2 Gene:

PTGS2 (prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)) is a protein-coding gene. Diseases associated with PTGS2 include bile duct cysts, and protoplasmic astrocytoma. GO annotations related to this gene include protein homodimerization activity and heme binding. An important paralog of this gene is PTGS1.