Abstract

Objective: To report selected dietary intake and vitamin status at baseline of volunteers participating in the ZENITH study and the correlation of vitamin status with zinc. Design: A multicentre prospective intervention study employing a randomised double-blind design. Setting: Clermont-Ferrand, Theix (France), Coleraine (Northern Ireland), Grenoble (France), Rome (Italy). Participants: In total, 387 healthy middle-aged (55-70 y) and older (70-87 y) men and women participated in the study. Methods: Dietary intake was assessed by means of a validated 4-d recall record. Fasting blood samples were simultaneously analysed for retinol and alpha-tocopherol by the HLPC method. Erythrocyte folates were measured by a competitive immunoassay with direct chemiluminescence detection on an automatised immunoanalyser. Results: In all centres, men had a significantly (P<0.0001) higher mean nutrient intake than women. Comparison between age-groups showed that older individuals had significantly lower intakes of macro- and selected micronutrients than middle-aged subjects (P<0.0001). A high fat intake (from 36 to 40% of total energy) was observed in all examined groups. In relation to biochemical measures of vitamin status, all parameters were above their respective cut-off values for normality and, thus, none of the subjects had biochemical evidence of deficiency of these selected vitamins. A moderate correlation was found with plasma vitamin A and serum zinc (r=0.12, P<0.05) or red blood cell zinc (r= 0.12, P<0.01) and with erythrocyte folates and red blood cell zinc (r=0.11, P<0.05). Conclusions: There were only moderate differences in the nutrient intake of the ZENITH study volunteers among the four European centres. Their biochemical status for retinol, a-tocopherol and folate appeared adequate.

title = "Estimation of intake and status of vitamin A, vitamin E and folate in older European adults: the ZENITH",

abstract = "Objective: To report selected dietary intake and vitamin status at baseline of volunteers participating in the ZENITH study and the correlation of vitamin status with zinc. Design: A multicentre prospective intervention study employing a randomised double-blind design. Setting: Clermont-Ferrand, Theix (France), Coleraine (Northern Ireland), Grenoble (France), Rome (Italy). Participants: In total, 387 healthy middle-aged (55-70 y) and older (70-87 y) men and women participated in the study. Methods: Dietary intake was assessed by means of a validated 4-d recall record. Fasting blood samples were simultaneously analysed for retinol and alpha-tocopherol by the HLPC method. Erythrocyte folates were measured by a competitive immunoassay with direct chemiluminescence detection on an automatised immunoanalyser. Results: In all centres, men had a significantly (P<0.0001) higher mean nutrient intake than women. Comparison between age-groups showed that older individuals had significantly lower intakes of macro- and selected micronutrients than middle-aged subjects (P<0.0001). A high fat intake (from 36 to 40{\%} of total energy) was observed in all examined groups. In relation to biochemical measures of vitamin status, all parameters were above their respective cut-off values for normality and, thus, none of the subjects had biochemical evidence of deficiency of these selected vitamins. A moderate correlation was found with plasma vitamin A and serum zinc (r=0.12, P<0.05) or red blood cell zinc (r= 0.12, P<0.01) and with erythrocyte folates and red blood cell zinc (r=0.11, P<0.05). Conclusions: There were only moderate differences in the nutrient intake of the ZENITH study volunteers among the four European centres. Their biochemical status for retinol, a-tocopherol and folate appeared adequate.",

author = "A Polito and F Intorre and M Andriollo-Sanchez and E Azzini and A Raguzzini and N Meunier and V Ducros and JM O'Connor and C Coudray and AM Roussel and G Maiani",

T1 - Estimation of intake and status of vitamin A, vitamin E and folate in older European adults: the ZENITH

AU - Polito, A

AU - Intorre, F

AU - Andriollo-Sanchez, M

AU - Azzini, E

AU - Raguzzini, A

AU - Meunier, N

AU - Ducros, V

AU - O'Connor, JM

AU - Coudray, C

AU - Roussel, AM

AU - Maiani, G

PY - 2005/11

Y1 - 2005/11

N2 - Objective: To report selected dietary intake and vitamin status at baseline of volunteers participating in the ZENITH study and the correlation of vitamin status with zinc. Design: A multicentre prospective intervention study employing a randomised double-blind design. Setting: Clermont-Ferrand, Theix (France), Coleraine (Northern Ireland), Grenoble (France), Rome (Italy). Participants: In total, 387 healthy middle-aged (55-70 y) and older (70-87 y) men and women participated in the study. Methods: Dietary intake was assessed by means of a validated 4-d recall record. Fasting blood samples were simultaneously analysed for retinol and alpha-tocopherol by the HLPC method. Erythrocyte folates were measured by a competitive immunoassay with direct chemiluminescence detection on an automatised immunoanalyser. Results: In all centres, men had a significantly (P<0.0001) higher mean nutrient intake than women. Comparison between age-groups showed that older individuals had significantly lower intakes of macro- and selected micronutrients than middle-aged subjects (P<0.0001). A high fat intake (from 36 to 40% of total energy) was observed in all examined groups. In relation to biochemical measures of vitamin status, all parameters were above their respective cut-off values for normality and, thus, none of the subjects had biochemical evidence of deficiency of these selected vitamins. A moderate correlation was found with plasma vitamin A and serum zinc (r=0.12, P<0.05) or red blood cell zinc (r= 0.12, P<0.01) and with erythrocyte folates and red blood cell zinc (r=0.11, P<0.05). Conclusions: There were only moderate differences in the nutrient intake of the ZENITH study volunteers among the four European centres. Their biochemical status for retinol, a-tocopherol and folate appeared adequate.

AB - Objective: To report selected dietary intake and vitamin status at baseline of volunteers participating in the ZENITH study and the correlation of vitamin status with zinc. Design: A multicentre prospective intervention study employing a randomised double-blind design. Setting: Clermont-Ferrand, Theix (France), Coleraine (Northern Ireland), Grenoble (France), Rome (Italy). Participants: In total, 387 healthy middle-aged (55-70 y) and older (70-87 y) men and women participated in the study. Methods: Dietary intake was assessed by means of a validated 4-d recall record. Fasting blood samples were simultaneously analysed for retinol and alpha-tocopherol by the HLPC method. Erythrocyte folates were measured by a competitive immunoassay with direct chemiluminescence detection on an automatised immunoanalyser. Results: In all centres, men had a significantly (P<0.0001) higher mean nutrient intake than women. Comparison between age-groups showed that older individuals had significantly lower intakes of macro- and selected micronutrients than middle-aged subjects (P<0.0001). A high fat intake (from 36 to 40% of total energy) was observed in all examined groups. In relation to biochemical measures of vitamin status, all parameters were above their respective cut-off values for normality and, thus, none of the subjects had biochemical evidence of deficiency of these selected vitamins. A moderate correlation was found with plasma vitamin A and serum zinc (r=0.12, P<0.05) or red blood cell zinc (r= 0.12, P<0.01) and with erythrocyte folates and red blood cell zinc (r=0.11, P<0.05). Conclusions: There were only moderate differences in the nutrient intake of the ZENITH study volunteers among the four European centres. Their biochemical status for retinol, a-tocopherol and folate appeared adequate.