FREE #RenalPath Cholesterol emboli usually occur in patients older than 50 years with a predilection in men and whites. Clinical presentation includes acute kidney injury, new onset hypertension, proteinuria that may be in the nephrotic range, hematuria, and occasionally increased eosinophils. Cholesterol emboli can involve all organs downstream of atherosclerotic plaques, including the lower extremities where it manifests as livedo reticularis. The kidney is the most common site of involvement, followed by the spleen, pancreas, gastrointestinal tract, and adrenal glands. Prognosis overall is poor, related to the underlying severe vascular disease and multi-organ complications bit.ly/2AEWkvD. ... See more

Frailty, the state of increased vulnerability to physical stressors as a result of progressive and sustained degeneration in multiple physiological systems, is common in those with chronic kidney disease (CKD). In fact, the prevalence of frailty in the older adult population is reported to be 11%, w... ... See more

Cognitive and emotional dysfunctions most often co-occur with metabolic disorders and/or poor dietary habits. The latest review article in npj Science of Food discusses the extent of, and mechanisms for, diet's influence on mood and cognition during different stages of life. ... See more

FREE #Editorial Living related donation has been considered a contraindication in #aHUS because of both the high risk for recurrence and the potential risk to donors in whom aHUS can be triggered by uninephrectomy in biological relatives who may carry complement gene abnormalities. Duineveld et al report good short-term posttransplantation outcomes in the 3 recipients of kidneys from a living related donor. Known genetic abnormalities were excluded before donation in 2 of the living related donors, whereas no information was provided for the third. However, data for these living related donors should be interpreted cautiously because aHUS is a complex genetic disorder, with multiple genetic factors including pathogenic variants and risk polymorphisms and haplotypes likely combining to determine the risk for relapse in the recipient and of aHUS onset in biological relatives bit.ly/2ABY2Qf. ... See more

This randomized clinical trial compares the effects of hemodialysis using a high-cutoff dialyzer (with very large membrane pores and high permeability to immunoglobulin light chains) vs a conventional high-flux dialyzer (with small pores and lower permeability) on hemodialysis independence among... ... See more

An 8-week course of sofosbuvir/ledipasvir (Harvoni) led to a sustained response in all people with HIV and genotype 1 or 4 hepatitis C virus (HCV) in the SWIFT-C study, according to a report at the AASLD Liver Meeting last month in Washington, DC. The advent of direct-acting antivirals (DAAs) has ma... ... See more