"+" or "-" indicates if the gene sequences have been found (+) or not been found (-)
rearranged (R),
transcribed (T) and/or translated into protein
(Pr). Arbitrarily that information is shown on the first line of each gene
when the data have been confirmed by several studies.

Functionality is shown between parentheses, (F) and (P), when the accession
number refers to rearranged genomic DNA or cDNA and the corresponding germline
gene has not yet been isolated.
Functionality is shown between brackets, [F] and [P], when the accession number
refers to genomic DNA, but not known as being germline or rearranged.

Click on:

IMGT gene name to get the corresponding IMGT/GENE-DB entry,

IMGT allele name to see the corresponding Alignments of alleles,

accession number to get the corresponding IMGT/LIGM-DB entry.

All the IGHV genes are in a fully sequenced contig which comprises the following accession numbers:

IGHV genes are designated by a number for the subgroup, followed by a dash and a number for the localization from 3' to 5' in the locus.
IGHV genes which had a provisional nomenclature (number for the subgroup, followed by a dash and a small letter) [12,51] have
now all been localized in the IGH locus.
The sequences previously designated as IGHV1-e have been shown to correspond to alleles IGHV1-69*06 and IGHV1-69*07.
The sequences previously designated as IGHV3-g have been shown to correspond to allele IGHV3-71*01.
The sequences previously designated as IGHV1-c, IGHV1-f, IGHV3-d, IGHV3-h, IGHV4-b and IGHV5-a have been assigned respectively to the definitive IMGT gene names
IGHV1-38-4, IGHV1-69-2, IGHV3-38-3, IGHV3-69-1, IGHV4-38-2 and IGHV5-10-1.

(4) INSERTION and DELETION of one nucleotide in FR1-IMGT and FR2-IMGT respectively.

(5) DELETION of one nucleotide in FR2.

(6) Absence of the conventional DONOR-SPLICE site (ngc instead of ngt) at the 5' end of the L-PART1, however this V-GENE has been seen rearranged in vivo.

(7) The DELETION of nucleotides 208 to 248 in M99645 EMBL flat file is probably a typing error. This DELETION does not exist in the paper.

(8) INSERTION of 4 nucleotides (tacc) between codons 28 and 29 in the FR1 leading to a frameshift.

(9) The sequence described in the manuscript is different from the one submitted to the EMBL data library. We refer to the sequence published in the original manuscript .

(10) Unusual V-HEPTAMER sequence (cacaaag instead of cacagtg) but this V-GENE has been seen rearranged.

(11) Unusual V-HEPTAMER and V-NONAMER sequences (cacaaag and acaaaaccc instead of cacagtg and acaaaaacc). g100>del ,g107>del, g117>del may result from sequencing errors in X62108. The sequence is probably identical to allele *02 with a CDR1-IMGT of 10 aminoacids, like the other IGHV2 subgroup genes.

(12) In frame STOP-CODON and recombination signal sequences not conserved.

(13) Unusual V-HEPTAMER sequence (cacagag instead of cacagtg) but this V-GENE has been seen rearranged.

(14) DELETION of one nucleotide in FR1 and unusual V-HEPTAMER sequence (tacggta).

(15) Differs from the prototype sequence by DELETIONs.

(16) Unusual V-HEPTAMER sequence : tcctgtg instead of cacagtg.

(17) Unusual V-HEPTAMER sequence : cactgtg instead of cacagtg, ACCEPTOR-SPLICE site at the 5' side of the V-EXON and second part of the leader exon (L-PART2) are missing.

(18) V-NONAMER sequence (acacaaacg) differs from the family consensus: acacaaacc but this V-GENE has been seen rearranged.

(19) In frame STOP-CODON at position 67 in FR3-IMGT, CONSERVED-TRP (tgg) residue at the beginning of FR2 is replaced by GLY (ggg).

(21) In frame STOP-CODON, CONSERVED_TRP (tgg) residue at the beginning of FR2 is replaced by CYS (tgt).

(22) In frame STOP-CODON and unusual V-HEPTAMER and V-NONAMER sequences.

(23) The M77323 sequence (Baj clone) has 1 nt deletion compared to the one displayed in figure 3 of Olee et al., J. Clin. Invest., 88, 193-203 (1991) [27]. As the gene is described as functional in the manuscript, one missing nt has been added at position 286 (codon 96) in the IMGT/GENE-DB reference sequence and in Alignment of alleles to maintain the reading frame.

(24) In frame STOP-CODON and unusual V-HEPTAMER and V-NONAMER sequences.

(35) In frame STOP-CODON in the leader exon and frameshift after residue 11 in the FR1.

(36) In frame STOP-CODON in the FR1.

(37) In frame STOP-CODON and unusual recombination signal sequences.

(38) The sequence described in the manuscript is different from the one submitted to the EMBL data library. We refer to the sequence published in the original manuscript. Deleterious mutations throughout the V-GENE affecting translation initiation, RNA spicing, frameshifts and recombination signals.

(39) The sequence described in the manuscript is different from the one submitted to the EMBL data library. We refer to the sequence published in the original manuscript. STOP-CODON at position 66 and mutation in the V-HEPTAMER recombination signal.

(40) The sequence described in the manuscript is different from the one submitted to the EMBL data library. We refer to the sequence published in the original manuscript. STOP-CODON at position 46 and mutation in the V-HEPTAMER recombination signal.

(41) In frame STOP-CODONs and not canonical recombination signal sequences.

(42) V-NONAMER differs from the subgroup consensus: acacaaacc but this V-GENE has been seen rearranged.

(43) Frameshift at the end of FR1.

(44) Unusual V-HEPTAMER recombination signal sequence: cacagcg instead of cacagtg this V-GENE has been seen rearranged.

(45) Frameshifts in V-REGION.

(46) In frame STOP-CODON and DELETION of 2 nucleotides at the end of FR2 leading to a translational frameshift.

(47) In frame STOP-CODON in CDR2.

(48) In frame STOP-CODON in CDR1 at position 35.

(49) The sequence described in the manuscript is different from the one submitted to the EMBL data library. We refer to the sequence submitted to the EMBL data library (X56359).

(50) Germline transcript.

(51) VH251 (M18806, Shen et al.) corrected by Sanz et al (X92226). The sequence (X92226) described in the manuscript is different from the one submitted to the EMBL data library : one nucleotide (g) inserted in the file compared to the publication. Correction asked to EMBL by IMGT and the authors (Capra, D.). Corrected 6th December 1996.

(52) 25 bp DELETION in the immediate 3' flank resulting in loss of the V-HEPTAMER and part of the spacer region [J. Exp. Med., 173, 1529-1535 (1991)]In addition in X92213, but not in the other sequences, there is an incorrect translation frame due to the INSERTION of two nucleotides (a730 and a732) in L-PART2, but these insertions may represent sequencing errors.

(53) One nucleotide INSERTION in L-PART1 and two nucleotides DELETIONS in CDR2 leading to a frameshift; 25 bp DELETION resulting in loss of the V-HEPTAMER and part of the spacer region [J. Exp. Med., 173, 1529-1535 (1991)].

(54) VH32 (X92279, Humphries et al.) corrected by Sanz et al. (X92227). The absence of nt in codon 96 in the sequence X92279 (c288>del compared with X92227) is a sequencing error because of an expressed cDNA (U00543) has been described. Therefore, the functionality of IGHV5-a*02 has been changed from pseudogene (P) to functional (F).

(56) In frame STOP-CODON and 14 bp DELETION between codons 87 and 88 in the FR3.

(57) Undetermined 5' region.

(58) In frame STOP-CODON at position 27.

(59) In frame STOP-CODON in FR1, 3 nucleotides DELETION in codon 52, 53 and 61 in CDR2 and one nucleotide INSERTION leading to translational frameshifts.

(60) The INSERTION of one nucleotide between position 195 and 196 in M99646 EMBL flat file is probably a typing error. This insertion does not exist in the paper.

(61) The two substitutions c46>t (P16>S) and g308>a (C103>Y) in the X56363 EMBL flat file are probably typing errors. These substitutions do not exist in the publication (VH4.19, Figure 1, Sanz I. et al. EMBO J. 1989, 8(12): 3741-3748. PMID: 2511001. The codon R106 (aga) also missing in the flat file has been added in the Alignment of alleles.

(62) This sequence has been assigned by IMGT to a previously described gene by sequence alignment.

(63) In EMBL/GenBank flat file, intron is missing. Request has been done by IMGT/LIGM-DB annotators for sequence correction.

(64) not found by Matsuda et al. J. Exp. Med. 188, 1-15 (1998).

(65) Unusual V-HEPTAMER (caccatg instead of cacagtg).

(66) ORF because Tyrosine (tat) instead of the 2nd-CYS at position 104.

(67) Functionality is not determined because the sequence is too partial.

(68) Except for the IGHV3-30-5*01 (AC244456 and KC162925) and the IGHV3-30-5*02 (AC245243), sequences of the polymorphic IGHV3-30-5 gene cannot be differenciated from those of the IGHV3-30 gene. All sequences are described therefore as "IGHV3-30 alleles" by comparison to the allele *01 of IGHV3-30 (M83134).However, it is not excluded that some of these "alleles" belong exclusively to the IGHV3-30-5 gene.

(69) Sequences of the polymorphic IGHV4-30-1 gene cannot be differenciated from those of the IGHV4-31 gene.All sequences are described therefore as "IGHV4-31 alleles" by comparison to the allele *01 of IGHV4-31 (L10098).However, it is not excluded that some of these "alleles" belong exclusively to the IGHV4-30-1 gene.

(70) Frameshifts in FR1-IMGT and CDR1-IMGT.

(71) Missing translation initiation codon, (atg) is replaced by (aag)

(72) "IGHV3-23*04" being assigned to AJ879486 in IMGT/GENE-DB, the sequence AY757302 was assigned to IGHV3-23*05 by IMGT-NC and represents the IMGT reference sequence for the IGHV3-23*05 allele.

(73) AY757303 is a representative of IGHV4-4*07 (100% similarity in the V-REGION) and was added in "Other Sequences from the literature" in IMGT/GENE-DB for IGHV4-4*07 allele.

(74) Arbitrary limits of the DNA sequence assigned to the different IGHV genes. V-GENE positions are those in the Accession numbers AB019437, AB019438, AB019439, AB019440, AB019441.

(75) It is not possible to assign these sequences to a single allele (owing, for example, to their partiality).

(76) In frame STOP-CODON in FR3-IMGT

(77) In frame STOP-CODONs in FR2-IMGT, No CONSERVED 1st-CYS

(78) C41 instead of W.(other alleles are Pseudo owing to a codon stop in 103.In HM855898 the codon stop is replaced by a Y).

(79) ORF because first Cys is replaced by Arginine.

(80) IMGT note: The sequence HM855939 obtained by Next Generation Sequencing (NGS) has the features of a chimeric sequence between two different genes belonging to the Homo sapiens IGHV3 subgroup (IGHV3-30*02 in 5' and IGHV3-23 or IGHV3-66 in 3'). Five other sequences obtained from NGS reads, HM855685, HM855784, HM855853, HM855863 and HM855880, are most probably duplicate copies of the same unique chimeric sequence. These chimeric sequences (HM855939 and the five duplicates) need therefore to be confirmed by analysis of other genomic and mapped germline clones (M-P. Lefranc, 17/12/10).

(89) The IGHV5-10-1 (F) and IGHV3-64D (F) genes have been described as a CNV and localized as an alternative to the presence of IGHV2-10 (P), IGHV3-9 (F) and IGHV1-8 (F) in one haplotype [Watson C.T. et al., Am. J. Hum. Genet., 92, 1-17 (2013)].

(90) STOP-CODON in L-PART1 and frameshifts and STOP-CODONs in V-REGION.

(91) Frameshifts and STOP-CODONs in V-REGION.

(92) The sequences Z12320 and L10059 previously designated as IGHV7-40*03 have been shown to correspond to allele IGHV7-34-1*01 (06/03/2014).

(93) ORF because non usual V-HEPTAMER, CACCATG instead of CACAGTG.

(94) In frame STOP-CODONs in L-PART1 and V-REGION.

(95) In frame STOP-CODONs in V-EXON and no V-RS.

(96) In frame STOP-CODONs in V-REGION.

(97) In-frame STOP-CODON: one in FR1-IMGT at position 24 and two in FR2-IMGT at positions 43 and 55.

(98) In frame STOP-CODONs in V-REGION at positions AA 38, 52 and 106.

(99) In frame STOP-CODON in L-PART1, in frame STOP-CODONs in V-REGION at positions AA 43, 44 and 54

(100) Positions of V-REGION

(101) Owing to a sequence gap and an assembly error, IGHV1-38-4 and IGHV(III)-38-1D positions appear downstream of IGHV4-38-2, whereas they should be located upstream of the IGHV(II)-43-1D - IGHV3-43D - IGHV3-42D -IGHV7-40D duplication.