Yes, the Prequel era is an excellent setting, you can play with a weakened Republic in the Phantom Menace era, or with Clone Wars for a military or roguish campaign. It would also be interesting to play a Separatist campaign, actually.

I do not play SW very often, but a few month ago I set a SWd6 game around the order 66 for my older son and my wife. They were young Jedis sent in a false mission - they survived the order and joined general Kenobi's forces. I hope we'll continue, but we have plans for family Pathfinder beginner's box for summer (playing Palace of the silver princess).