Oh! Edo Rocket is a wild comedy series set in the Edo period of Japan. There is a harsh new law against the creation and display of fireworks, but Seikichi, a young fireworks maker, is asked by a mysterious girl to make one powerful enough to reach the moon.

This takes place in a world where alchemy is possible and performed by people, known as alchemists, manipulating things by willing it. Edward and Alphonse Elric go on a search for the legendary Philosopher's Stone to restore their bodies after an alchemy accident destroyed them.