Ostbeta (show OSTBETA Antibodies) is required for both proper trafficking of Ostalpha and formation of the functional transport unit, and identify specific residues of Ostbeta (show OSTBETA Antibodies) critical for these processes.

The present report summarizes the evidence for a pleiotropic role of Ostalpha-Ostbeta (show OSTBETA Antibodies) in different tissues.

OSTalpha has roles in biological transport and is widely expressed in human tissues

the selective localization of OSTalpha and OSTbeta (show OSTBETA Antibodies) to the basolateral plasma membrane of epithelial cells responsible for bile acid and sterol reabsorption.

These results indicate that expression of Ostalpha and Ostbeta (show OSTBETA Antibodies) are highly regulated in response to cholestasis and that this response is dependent on the FXR bile acid receptor (show NR1H4 Antibodies).

OSTalpha is localized to steroidogenic cells of the brain and adrenal gland, and it modulates DHEA/DHEAS (show SULT2A1 Antibodies) homeostasis

These findings indicate that loss of Ostalpha provides protection from liver injury in obstructive cholestasis through adaptive responses in both the kidney and liver that enhance clearance of bile acids into urine.

Co-expression of mouse Ostalpha-Ostbeta (show OSTBETA Antibodies), but not the individual subunits, stimulated Na(+)-independent bile acid uptake and the apical-to-basolateral transport of taurocholate

the selective localization of OSTalpha and OSTbeta (show OSTBETA Antibodies) to the basolateral plasma membrane of epithelial cells responsible for bile acid and sterol reabsorption.

Organic Solute Transporter alpha (OSTALPHA) Antigen Profile

Protein Summary

Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood. Efficiently transports the major species of bile acids (By similarity).