Simeon P CairnsInstitute of Sport and Recreation Research New Zealand, Faculty of Health and Environmental Science, Auckland University of Technology, Auckland, New ZealandJ Appl Physiol (1985) 103:359-68. 2007

Protective role of extracellular chloride in fatigue of isolated mammalian skeletal muscle

Simeon P CairnsInstitute of Sport and Recreation Research New Zealand, Faculty of Health and Environmental Sciences, Auckland University of Technology, Auckland, New ZealandSports Med 36:279-91. 2006

..To reconcile the findings from isolated muscle fibres through to whole-body exercise, it is hypothesised that a severe plasma acidosis in humans might impair exercise performance by causing a reduced CNS drive to muscle...

Changes of action potentials and force at lowered [Na+]o in mouse skeletal muscle: implications for fatigue

..We hypothesize that during high-intensity exercise a rundown of the transsarcolemmal K(+) gradient is the dominant cellular process around which interactions with other ions and metabolites occur, thereby contributing to fatigue...

Simeon P CairnsInstitute of Sport and Recreation Research New Zealand, Faculty of Health and Environmental Science, Auckland University of Technology, Auckland, New ZealandJ Appl Physiol (1985) 103:359-68. 2007

..Using this new understanding, we showed that disrupted propagation of action potentials along the surface membrane is a major cause of fatigue in soleus muscle that is focally and continuously stimulated at 125 Hz...

Protective role of extracellular chloride in fatigue of isolated mammalian skeletal muscle

..These data suggest that with prolonged cycling: (1) there is considerable and a persistent form of central fatigue, (2) there is an increased level of cortical arousal, and (3) exhaustion is linked to very high subjective RPE...