Public Health Event Reporting: Lecture Template

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1 Public Health Event Reporting: Lecture TemplateNotes:This lecture is intended to be used to provide an introduction or reinforce previous training on public health event reporting.The target audience for this presentation is clinicians and other frontline healthcare workers responsible for disease reporting.The slides were prepared by the REACT Work Package 6 Project Team.These slides are templates that should be adapted, removed or supplemented by the presenter. The notes are provided as a suggestion only.The slide set can be combined with the Discussion Workshop templates as part of a full training package.Where possible, references to the information presented on the slide are provided.1

2 ObjectivesTo provide an overview of public health event reporting globally and in this countryTo briefly outline the surveillance obligations of the International Health Regulations 2005To discuss the role of clinicians/laboratories in the public health event reporting chainTo present examples of ‘unusual events’ recognised at the local levelNotes:The material included in this presentation attempt to fulfil the objectives stated on this slide.Objectives may need to be modified to meet the audience’s needs. The presenter may wish to focus on fewer objectives.

3 Two objectives of surveillanceMeasuring distribution of cases of disease by time, place, and personEmphasis on medium and long term changesDetecting unusual events (outbreaks)A) Detecting sudden changes in numbersB) Detecting events (event surveillance)This is part of epidemic intelligenceNotes:Surveillance can serve a number of purposes, such as estimating disease occurrence, monitoring trends, evaluating control measures, detecting individual cases or epidemics, tracking contacts or facilitating planning of public health interventions.Most public health surveillance systems consist of several main branches, which are: a) the systematic collection of relevant data, b) analyses of these data and c) the timely dissemination of results to guide control and prevention activities.Two main objectives of surveillance: 1) measuring distribution of cases of diseases by time, place and person, and 2) detecting unusual events (outbreaks).References:M'ikanatha N, Lynfield R, Julian K, Van Beneden C, de Valk H. Infectious disease surveillance: a coernerstone for prevention and control. In: M'ikanatha N, Lynfield R, Van Beneden C, de Valk H, editors. Infectious Disease Surveillance. 1 ed. Oxford: Blackwell Publishing LTD.; p

4 Epidemic IntelligenceDefinition: All the activities related to early identification of potential health threats, their verification, assessment and investigation as a basis for recommending control measures.That is: detecting and investigating events (outbreaks and others)Notes:The European Centre for Disease Prevention and Control (ECDC) proposed the Epidemic Intelligence framework as a way for countries to view national public health surveillance.Definition: “All activities related to early identification of potential health hazards, their verification, assessment and investigation in order to recommend public health control measures”.Recent international health events such as the 2003 Severe Acute Respiratory Syndrome (SARS) outbreak and the 2009 H1N1 Pandemic have highlighted the need for new, faster methods of detection and reporting.References:Kaiser R, Coulombier D, Baldari M, Morgan M, Paquet C. What is epidemic intelligence, and how is it being improved in Europe? Eurosurveillance 2006;11(2).Paquet C, Coulombier D, Kaiser R, Coulombier D, Ciotti M. Epidemic intelligence: a new framework for strengthening disease surveillance in Europe. Eurosurveillance 2006;11(12).

5 Indicator-based component: Event-based component:Epidemic Intelligence FrameworkIndicator-based component:surveillance systemsEvent-based component:event monitoringDataEventsSignalNotes:Event-based surveillance: the organized and rapid capture of information about events that are a potential risk to public health.Traditionally, communicable disease surveillance has relied on indicator-based methods. Indicator-based surveillance activities are generally based on routine reporting of cases of disease.Unlike indicator-based surveillance, event-based surveillance is not based on the routine collection of data and automated thresholds for action but rather on unstructured descriptions and reports.Traditional “surveillance” systems make up the indicator-based portion while event-monitoring systems compose the event-based portion.Because of the broad definition, event-based surveillance can involve partners other than health care professionals, such as the agriculture, environment, industry, and education sectors to make reports.References:Paquet C, Coulombier D, Kaiser R, Coulombier D, Ciotti M. Epidemic intelligence: a new framework for strengthening disease surveillance in Europe. Eurosurveillance 2006;11(12).World Health Organization Western Pacific Region. A Guide to Establishing Event-based Surveillance. Geneva: World Health Organization; 2008.Reportto WHOPublic health alertControl measures

6 Notifiable disease reportingIn this country, X number of diseases are reportableDiffering reporting timeframes for different diseasesClinicians and laboratories are legally obligated to reportNotes:Notifiable disease surveillance is considered a passive surveillance system, as it relies on physicians or other health care professionals to report cases of specific diseases to public health authorities.Notifiable disease reporting systems are typically health-care-facility-based and, depending on the disease, reports tend to be required daily, weekly or monthly.The slide should be changed to include brief information regarding the status of notifiable diseases in the country/region. Additional slides regarding notifiable diseases may be added as required (for example different reporting time frames for different categories of diseases).State which individuals in the country are legally responsible for disease reporting.The focus of the lecture is event reporting – these slides are intended to briefly describe the notifiable diseases reporting system in order to clarify the relationship between event reporting and notifiable reporting.References:Morgan O, Pinner R. Surveillance of Infectious Diseases. In: Moselio Schaechter, editor. Encyclopedia of Microbiology. 3 ed. Oxford: Elseveier; p

7 From infection to detectionspecificityREPORTPOS. SPECIMENCLINICAL SPECIMENSEEK MEDICAL ATTENTIONSYMPTOMSNotes:Notifiable diseases are typically reported by the clinician or the laboratory following positive laboratory confirmationReporting on suspicion of a notifiable disease may occur when a patient seeks medical attentionThe reports only represent the tip of the icebergFor example, from 1000 Shigella infections, on 50 cases might be notified (5%)INFECTEDEXPOSEDsensitivity

8 Limitations of notifiable disease reportingNotifiable diseases are underreportedEmerging diseases not on notifiable disease listDelay between reporting and responseLack of knowledge: reporting requirements and proceduresNotes:Underreporting of notifiable diseases is extensively documented.Some countries include “any outbreak” or “any event deemed unusual by the clinician” on the notifiable list while others do not legally address public health events in their notifiable disease lists.Delays related to waiting for laboratory confirmation or aggregation of reported data can lead to delays in public health action.One of the most frequently stated reasons among physicians for not reporting is a lack of knowledge of the reporting process, including not knowing how to report and not knowing what diseases are reportable.Confusion (for example between the laboratory and the clinician) over who will report has also been identified as a common reason for reporting incompleteness in studies from several countriesReferences:Doyle T, Glynn M, Groseclose S. Completeness of Notifiable Infectious Disease Reporting in the United States: An Analytical Literature Review. American Journal of Epidemiology 2002;155:866-74Konowitz P, PetrossIan G, Rose D. The Underreporting of Disease and Physicians' Knowledge of Reporting Requirements. Public Health Reports 1984;99:31-5.Silk B, Berkelman R. A Review of Strategies for Enhancing the Completeness of Notifiable Disease Reporting. J Public Health Management Practice 2005;11:

9 What is a public health event?The definition is intentionally vagueA cluster of casesAn outbreak or epidemicA single caseContamination of foodChemical, nuclear or radiological releasesEvent reporting is done in addition to notifiable disease reportingNotes:The definition of an event is not limited to infectious diseaseWhether or not an event is of public health significance is dependant on the context. For example, one case of cholera in Stockholm may be of significance on the local or even national level, but perhaps not on the international level. However, one case of a novel disease might be a public health event of international significance.Event reporting compliments notifiable disease reporting. Event reporting serves a different purpose than notifiable reporting and is particularly important when timely reporting can lead to a faster, more successful response.References:Aavitsland P. International Surveillance with the New International Health Regulations. EpiNorth 2008.World Health Organization Western Pacific Region. A Guide to Establishing Event-based Surveillance. Geneva: World Health Organization; 2008.

10 Selected emerging and re-emerging infectious diseases, 1996 - 2004Notes:An emerging/re-emerging infection is a public health event. Perhaps the most well known example = SARSEmerging infections are defined as “infections that have newly appeared in a population or have existed but are rapidly increasing in incidence or geographic range” while re-emerging diseases are those that were decreasing but have started increasing again, like TB.Emergence can result due to a number of factors, including ecological changes, human demographics and behaviour, international travel and commerce, technology and industry, microbial adaptation and change, and breakdown in public health measures.Challenge is how to ensure a novel public health event is detected, assessed, reported and controlled when no specific criteria, case definitions or reporting guidelines exist.References:Morens DM, Folkers GK, Fauci AS. The challenge of emerging and re-emerging infectious diseases. Nature. 2004; 430:Heymann DL. SARS and Emerging Infectious Diseases: A Challenge to Place Global Solidarity above National Sovereignty. Ann Acad Med Singapore 2006; 35: 350-3Morse S. Factors in the Emergence of Infectious Diseases. Emerging Infectious Diseases 1995;1: 7-15World Health Organization. The World Health Report 2007: A Safer Future: Global public health security in the 21st century. Geneva: World Health Organization; 2007.Source: World Health Report 2007

11 The International Health Regulations 2005Came into force in 2007Require countries to notify the WHO of any events of potential international public health significancePHEICIHR 2005 provides an algorithm to assist national-level public health authorities determine whether an event is reportableNotes:The IHR 2005 came into force in June 2007.The IHR 2005 was revised to address many shortcomings of the previous IHR, including limited coverage, dependence on country notification, lack of incentives, lack of mechanisms of cooperation and lack of risk-specific measures.The IHR 2005 obligates State Parties to maintain the capacity to detect, assess, report and notify all public health emergencies of international concern (PHEIC) to the World Health Organization (WHO).One of the most significant changes is the expansion of the scope from previous versions to require the notification of any event “that may constitute an emergency of international concern”.The IHR 2005 requires that every member state establish a National Focal Point (NFP), or a “national centre, designated by each State Party, which shall be accessible at all times for communications with WHO IHR Contact Points”. The NFP is responsible for all communication with the WHO regarding event notification.References:Baker M, Fidler D. Global Public Health Surveillance under New International Health Regulations.Emerging Infectious Diseases 2006; 12:Cash R, Narasimhan V. Impediments to global surveillance of infectious diseases: consequences of open reporting in a global economy. Bulletin of the World Health Organization 2000;78:Katz R, Allen H. Domestic Understanding of the Revised International Health Regulations. Public Health Reports 2009;124:Rodier G, Hardiman M, Plotkin B, Ganter B. Implementing the International Health Regulations (2005) in Europe. Eurosurveillance 2006;11(12).World Health Organization International Health Regulations Revision Project. Global Crises - Global Solutions: Managing public health emergencies of international concern through the revised International Health Regulations. Geneva: World Health Organization; 2002

12 Annex 2 of the IHR 2005 3 categories of diseases Must always reportMust always lead to use of algorithm4 questions in the algorithmNotes:IHR 2005 provides some guidance on how to evaluate public health events of potential international concern in Annex 2.The algorithm lists several diseases for which the occurrence of one case is considered “unusual or unexpected” and can have a serious public health impact, and therefore must be reported to the WHO under any circumstances. These diseases are smallpox, poliomyelitis due to wild-type poliovirus, human influenza caused by new subtypes and SARS.A second list of diseases is also provided, for which a single case always requires the use of the algorithm to determine whether it merits reporting. These diseases include cholera, pneumonic plague, yellow fever, viral hemorrhagic fevers, West Nile fever and other diseases of regional concern such as dengue fever, Rift Valley fever and meningococcal disease.Any event of potential international public health concern, including those involving other events or diseases than those in either list provided shall lead to the utilization of the algorithm. The algorithm uses four questions to determine whether an event is notifiable.References:Gostin L. International Infectious Disease Law: Revision of the World Health Organization's International Health Regulations. JAMA 2004;291:Heymann D. SARS and Emerging Infectious Diseases: A Challenge to Place Global Solidarity above National Sovereignty. Ann Acad Med Singapore 2006;35:350-3World Health Organization. International Health Regulations d Ed. Geneva: World Health Organization; 2008.

13 Annex 2 Criteria 4 risk assessment questions:Is the public health impact of the event serious?Is the event unusual or unexpected?Is there a significant risk of international spread?Is there a significant risk of international trade or travel restrictions?Events that meet 2 or more of the criteria must be reported to the WHO within 24 hoursNotes:A country’s NFP can use the algorithm to assess whether any other event meets the following four criteria:Is the public health impact of the event serious?Is the event unusual or unexpected?Is there a significant risk of international spread?Is there a significant risk of international trade or travel restrictions?If an event meets two or more of the four defined criteria, the NFP must notify the event to the WHO within 24 hoursReferences:Rodier G, Hardiman M, Plotkin B, Ganter B. Implementing the International Health Regulations (2005) in Europe. Eurosurveillance 2006;11(12).World Health Organization. International Health Regulations d Ed. Geneva: World Health Organization; 2008.

14 Reporting is the start of a dialogueClinicians,laboratoriesand other sourcesHigh sensitivity,Low positivepredictive valueLocal/regionalpublic healthauthoritiesNotes:The success of the IHR 2005 is entirely dependant on national and sub-national surveillance.For events to be reported to the WHO, the designated National Focal Point (NFP) must receive complete and timely information from local, regional and national health authorities that detect potential events.Clinicians do not need to worry about the IHR reporting criteria. The overview of Annex 2 was provided as context/background. Area that is of primary concern in this lecture is the orange dotted box = the reporting relationship between clinicians/laboratories/other sources and the local public health authority.IHR 2005 is NOT the only reason public health event reporting is important! The intrinsic public health benefits are reason alone.Expected that not all reports will be of public health significance, and the number of reports of interest to the next level of public health authority will decrease significantly. This, however, relies on assessment on each level.References:Armstrong et al. Capacity of Public Health Surveillance to Comply with Revised International Health Regulations, USA. Emerging Infectious Diseases 2010; 16:NationalIHR Focal PointWorld HealthOrganization

15 Role of the Clinician Point of entry into the reporting chainThe clinician’s professional judgment is an important resourceIs this unusual in my practice?Not responsible for determining whether an event is of “international public health significance” or reporting to IHRNotes:Hospital- and community-based physicians are important partners in the initial recognition and reporting of public health events.Primary care is a “key frontline ‘window’ to indentify public health threats (e.g. disease outbreaks, environmental health exposures), enabling the initiation of public health strategies (e.g. tracing contacts of patients with communicable disease, environmental investigations)”The clinician bears the primary responsibility for the first steps in disease reporting: consideration of a disease of potential public health significance.Community-based physicians that “know” their practice populations are better positioned to notice unusual or unexpected events.Although treatment of the patient is of the utmost importance, prevention of future illness in the community is also vital.In many jurisdictions, a medical officer or other public health authority will complete the additional tasks required after a report has been received.References:Sikora C, Johnson D. The family physician and the public health perspective: Opportunities for improved health of family practice patient populations. Canadian Family Physician. 2009; 55:Hagan JE, Whitney C. First Line of Defense: The Clinician’s Role in Detecting Respiratory Disease Outbreaks in the Era of Avian Influenza. Ed. Infectious Diseases in Clinical Practice. 2006: 14; 1-5

16 Role of the LaboratoryMicrobiologists positioned at public health microbiology disciplines are expected to identify, characterise and report on both common and uncommon microbiological findings.Public health authorities and clinicians rely on microbiologistsNotes:Microbiologists positioned at public health microbiology disciplines (e.g. diagnostics, clinical, veterinary, and environmental laboratories) are expected to identify, characterise and report on both common and uncommon microbiological findings.Public health authorities and clinicians rely on microbiologists in order to detect, assess and respond to events of public health concern.Microbiologists positioned within different laboratories, or disciplines, may observe events with multiple sources. In order to easily identify public health threats and provide a coordinated and timely response, compiled reports from microbiologists working at different sites are essential.

17 A public health event that could be detected by a clinician:Any outbreak of diseaseAny uncommon illness of potential public health significanceAny infectious or infectious-like syndrome considered unusual by the clinician, based onfrequencycircumstances of occurrenceclinical presentationseverityNotes:Determining whether an event is of public health significance is dependant on context and scale. An event may be of public health significance at the local level but not at the national level. Clinicians are not responsible for assessing whether events are of national or international public health significance.Clinicians are responsible for assessing whether an event is of public health significance in their own community. These are examples of what might constitute an event of public health significance at the local level (but not necessarily an exhaustive list).frequency (e.g., a sudden, unexplained, significant increase in the number of patients, especially when it occurs outside the normal season)circumstances of occurrence (e.g., many patients coming from the same location or participating in similar activitiesclinical presentation (e.g., a patient’s health rapidly deteriorating out of proportion to the presenting symptoms and diagnosis)severity (e.g., a number of patients failing to respond to treatments)References:Hagan JE, Whitney C. First Line of Defense: The Clinician’s Role in Detecting Respiratory Disease Outbreaks in the Era of Avian Influenza. Ed. Infectious Diseases in Clinical Practice. 2006: 14; 1-5Lee B. The Role of Internists During Epidemic, Outbreaks and Bioterrorist Attacks. J Gen Intern Med 2007; 22:

18 A public health event could be detected by a lab through:Received samplesFrequencyCircumstances of occurrenceClinical descriptionTest resultsUnexpected number of the same:Species/subspeciesStrain type/subtypeAntimicrobial resistance patternFailure or uncertainty in diagnosticsUnexpected failure in antimicrobial susceptibility testingNotes:A laboratory reportable unusual event could be any infectious or infectious-like complications considered unusual by the microbiologist and be related to:Received samples:frequency (e.g., unexpected, unexplained, increase in the number of samples; for instance, many stool samples received with similar analytical request)circumstances of occurrence (e.g., similar requests for analysis of samples from patients coming from various geographical locations within a limited time frame)clinical description (e.g., samples from several patients with unclear but similar clinical picture within a limited time frame)Test results:unexpected number of the same:Species/subspeciesStrain type/subtypeAntimicrobial resistance patternfailure or uncertainty in diagnosticsUnexpected failure in antimicrobial susceptibility testing

19 Why report an unusual event?First step in the reporting chainReporting early = minimize impact of a public health event?Delays related to confirmation of diagnosis/laboratory testingPH authorities do not have regular contact with patients – dependant on the clinicianNotes:Reporting on suspicion may result in early detection of an event of public health significance.Clinicians have contact with patients and are therefore better positioned to indentify an unusual event.Several examples from the last decade exist of infectious respiratory disease outbreaks that were detected and ultimately controlled because of timely reporting by astute practicing clinicians who knew that the patients they were seeing had unusual illnesses:SARSHantavirus pulmonary syndromeInhalational anthraxReferences:Hagan JE, Whitney C. First Line of Defense: The Clinician’s Role in Detecting Respiratory Disease Outbreaks in the Era of Avian Influenza. Ed. Infectious Diseases in Clinical Practice. 2006: 14; 1-5World Health Organization. The World Health Report 2003: Shaping the Future. Geneva: World Health Organization; Available at:Duchin JS, Koster FT, Peters CJ, Tempest B et al. Hantavirus pulmonary syndrome: a clinical description of 17 patients with a newly recognized disease. The Hantavirus Study Group. N Engl J Med. 1994; 330:Bush LM, Abrams BH, Beall A, Johnson CC. Index case of fatal inhalational anthrax due to bioterrorism in the United States. N Engl J Med. 2001; 345:

20 What happens after you report…Mutual exchange of information between the clinician and public health authority is crucialAssessment of the public health event:The nature of the eventThe nature of the diseaseThe impact of the eventPotential for spreadPreventabilityOther factors?Notes:The success of event reporting is directly linked to good communication between stakeholders in the reporting system.Additional slides detailing local practices or specific roles/responsibilities of clinicians, laboratory staff and public health authorities may enhance this sectionReferences:Perrett K, al-Wali W, Read C, Redgrave P, Trend U. Outbreak of meningococcal disease in Rotherham illustrates the value of coordination, communication, and collaboration in management. Communicable disease and public health. 2000; 3:

21 Risk assessment and public health actionNot all public health event reports will results in public health actionResults of the risk assessment:Clinical case management without public health actionInvestigation (clinical, epidemiological, microbiological and/or environmental) that may or may not result in a public health interventionNotes:Include specific risk assessment criteria if they have been developed for your area.

22 How to report an unusual eventInsert LOCAL REPORTING INFORMATIONImmediate reports vs. Aggregate reportsPhone numbersWebsitesElectronic formsPaperFaxEtc.Notes:Include local reporting information in this slide, such as contact information and expected timeframes.Clarify the type of events that require immediate notification versus those that can be managed using standard disease reporting measures.

23 Additional informationNo consequences for over-reporting!When in doubt, report.PH authorities must be prepared to respond to public health event reportsNotes:Emphasize that over-reporting will not result in negative consequences

24 ConfidentialityDoctor-patient confidentiality laws do not prevent clinicians from reporting public health eventsDescribe any country-specific confidentiality lawsNotes:Use this slide to clarify any confidentiality laws/procedures that may exist in the country.

25 Reporting legislation*Briefly outline of any legislation in the country related to event reportingFor example:Physicians have a duty to report certain communicable diseases to public health authorities. The duty of physicians to notify public health of contagious disease is addressed in section 83 of the Health Act.Where a physician knows or suspects that an animal or another person is suffering from or has died from a communicable disease, he shall, without delay and in accordance with section 4, make a report to the medical health officer if the disease is a) listed in Schedule A, or b) becomes epidemic or shows unusual features.Notes:Include specific legal disease reporting requirements, highlighting any portions that address public health event reporting.The content of this slide is a fictional example of legislation only.

27 Key messages Why report unusual events? What events are reportable?What happens after you report an unusual event?Examples of event reportingHow to report an unusual event?These messages are emphasized inthe “Leaflet for Clinicians” and “Leaflet for Laboratories”