1) Pitch match and loudness balance tests were used for detailed measurements of tinnitus which accompanied various inner ear disease. A pure-tone audiometer was used for the measurements. Inner ear anesthesia using Iidocaine and an intratympanic infusion of dexamethasone were used to treat various types of tinnitus. Inner ear anesthesia was highly effective in treating tinnitus occurring with sudden deafness and inner ear vertigo, but not for tinnitus accompanying head trauma and streptomycin toxicity. Intratympanic dexamethasone was highly effective in treating tinnitus accompanying chronic otitis media, syphilitic labyrinthitis and Meniere's disease but not against tinnitus due to head trauma.2) Treatment of inner ear vertigo such as Meniere's disease were also examined. The effectiveness of inner ear anesthesia ear anesthesia for Meniere's disease according to the AAO-HNS criteria was complete suppression in 56%, marked effectiveness in 25%, effectiveness in 5%, ineffectiveness in
… More4% and worse in 10%. The effectiveness of intratympanic dexamethasone was complete suppression in 57%, marked effectiveness in 23%, effectiveness in 8%, ineffectiveness in 10% and worse in 2%. These results is a useful treatment for inner ear disturbances such as vertigo and tinnitus.3) Inner ear anesthesia was performed in 10 patients with unilateral peripheral vestibular disturbance due mainly Meniere's disease, and OKAN reactions were examined before and after inner ear anesthesia. Bilateral OKAN-I was suppressed after unilateral anesthesia of inner ear, followed by early appearance of bilateral OKAN-C.According to these results, the vestibular compensation from the vestibulo-cerebellum appears to act on the night and left velocity storage integrators symmetrically. The human OKAN accurately reflected vestibular compensation mediated by a velocity storage mechanism. Our results comfirm that the OKAN reaction mediated by a velocity storage mechanism reflects pathological changes in the inner ear, and suggest that electrophysiologic examinations of ocular movements such as OKAN are useful in investigating the pathology of inner ear disease.これらの鼓室内薬剤注入法は、めまいや耳鳴などの内耳障害に対する有効な局所療法であることが確認された。3)メニエール病を中心とする一側末梢前庭障害10症例に内耳麻酔を行いその前後でのOKANの反応態度を検討した。一側内耳麻酔後にはOKANのI相は両側性に抑制され、II相が両側性に早期から出現した。これらのOKANの反応は前庭代償の強い表れと考察された。また前庭小脳からの代償作用は左右の速度蓄積機構に対称性作用していた。すなわち内耳の病態の変化が速度蓄積機構を介してOKANの反応上によく反映していることが確認できた。これはOKANなどの眼球運動に関する電気生理学的検査方法が内耳疾患の病態の検索にも有用であることを示している。 Less