Specifications: Cardiac Troponin I antibody [MF4]

Full Name

troponin I type 3 (cardiac)

Product Description

Mouse monoclonal [MF4] to cardiac Troponin I

Background

Troponin I is part of a heteromeric complex playing an important role in the regulation of skeletal and cardiac muscle contraction. It consists of three subunits, troponin I (TnI), troponin T (TnT) and troponin C (TnC). Each subunit is responsible for part of troponin complex function. E.g. TnI inhibits ATP-ase activity of acto-myosin. TnT and TnI are presented in cardiac muscles in different forms than in skeletal muscles. Only one tissue-specific isoform of TnI is described for cardiac muscle tissue (cTnI). cTnI is expressed only in myocardium.

This antibody is reacting with free cardiac troponin I (cTnI) and cTnI forming complexes with other troponin components (In the presence of 5 mM EDTA). It is not affected by heparin, phosphorylation, oxidation and troponin complex formation.This antibody does not cross-react with skeletal muscle troponin I.

Host

Mouse

Clonality

Monoclonal

Clone Name

MF4

Target

Cardiac Troponin I

Isotype

IgG1

Immunogen

epitope:190 – 196 a.a of human cardiac Troponin I

Antigen Species

Human

Species Reactivity

Human, Dog, Pig, Rat, Cat, Goat, Bovine

Storage Conditions: Cardiac Troponin I antibody [MF4]

Storage Buffer

Preservative: 0.1% Sodium Azide; Constituents: PBS. pH 7.4

Notes

For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.