This study initially investigate the correlation of
increased brain iron accumulation with the severity of cognitive impairment
in patients with Alzheimers disease using advanced quantitative R2' mapping.
The results revealed that R2' is a reliable parameter in measuring brain iron
deposition in AD patients; Furthermore, regional R2' and brain iron
concentration, especially which of bilateral hippocampus and parietal cortex,
were significantly positive correlated with the severity of cognitive
impairment, indicating that R2' can be used as an imaging marker to evaluate
disease progression. R2' technique might provide exciting potential
applications to the diagnosis, longitudinal monitoring, and therapeutic
development for AD.