The festival will feature Ono with the Plastic Ono Band, Patti Smith, Savages, Iggy and the Stooges, Deerhoof, Boy George, Marianne Faithfull, Immortal Technique, Ryuichi Sakamoto with Alva Noto, Sean Lennon with Cibo Matto, and Siouxsie Sioux's first show in five years. It will also include separate sets from Kim Gordon and Thurston Moore, who released a collaborative record with Ono last year.

On the final night, a group of "very special guests" will perform Ono and John Lennon's final record, 1980's Double Fantasy, which was released three weeks before Lennon's death.

Along with music, Peaches will perform one of Ono's most widely regarded performance art pieces, 1964's "Cut Piece". There will be the first screening of Sergei Eisenstein's 1925 film Battleship Potemkin accompanied by the Pet Shop Boys' 2004 score. And the festival will also include comedian Reggie Watts, a silent disco, and political speakers. (Ono told The Guardian, "There will definitely be an element of feminism and the plight of women.")