In 2018, we’ll be celebrating many significant pop culture anniversaries from “2001: A Space Odyssey” and “Grease” to the arrival of “Sex and the City” and departure of “Seinfeld.” Here’s our annual, extremely subjective list of notable anniversaries — designed, as always, to make you shout out loud, “I can’t believe it’s been that long!”

50th anniversary: On these dates in 1968

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"Rowan & Martin’s Laugh-In" premieres

JAN. 22 Fast-paced (for the time) laugh-a-minute hour that revolutionized the sketch-variety show (for the time). Some say presidential candidate Richard Nixon’s September cameo (“Sock it to me?”) helped give him the edge in his neck-and-neck race with Hubert Humphrey. Pictured: Dick Rowan, left, and Dick Martin

Otis Redding's '(Sittin' on) the Dock of the Bay' hits No. 1

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MARCH 16 This wistful posthumous hit, recorded three days before his death in a December 1967 plane crash, was the soul singer’s legacy.

'2001: A Space Odyssey' hits theaters

Photo Credit: MGM

APRIL 6 Stanley Kubrick’s film would break sci-fi barriers. How sad is it that today when we hear its majestic theme song (“Thus Spake Zarathustra”), we first think of the 1970s Elvis waddling on stage. Pictured: Keir Dullea

'60 Minutes' debuts

40th anniversary: On these dates in 1978

Photo Credit: Capitol / UMe

“Saturday Night Fever” fever

MAY 13 Yvonne Elliman’s rendition of “If I Can’t Have You,” hit No. 1. In doing so, the movie’s soundtrack album became the first soundtrack to score four No. 1 singles — a record that still stands. The others were three BeeGees’ songs: “Night Fever,” “Stayin’ Alive” and “How Deep Is Your Love.”

'Grease' hits theaters

Photo Credit: Paramount Pictures

JUNE 16 The ’50s-set movie (based on the Broadway musical) that millions are still hopelessly devoted to. Pictured: Olivia Newton-John and John Travolta

'National Lampoon’s Animal House' debuts

Photo Credit: Universal Studios Home Entertainment

JULY 28 Double secret probation . . . “Fat, drunk and stupid is no way to go through life.” . . . “Toga! Toga! Toga!” What more can we say?

20th anniversary: On these dates in 1998

MARCH 23 “Titanic” dominates the 70th Academy Awards ceremony. Director James Cameron lets everybody know that he’s “the king of the world!”

'Seinfeld' ends

Photo Credit: NBC/Chris Hastom

MAY 14 The fabled show about “nothing” went out with a one-hour episode in which the four pals end up jailed for violating a small town’s good Samaritan law. Their crime: They did “nothing” to stop a carjacking. Pictured: Michael Richards, left, Jerry Seinfeld, Julia Louis Dreyfuss, Jason Alexander

Britney Spears releases “ . . . Baby One More Time”

Photo Credit: Jive

SEPT. 30 The former Mouseketeer’s first single would go on to sell 10 million copies.

10th anniversary: On these dates in 2008

Photo Credit: AMC

“Breaking Bad" debuts

JAN. 20 Before this powerful drama debuted, we just knew Bryan Cranston as a dorky dentist (“Seinfeld”) and a dorky dad (“Malcolm in the Middle.”) Who knew that his dorky chem teacher would evolve into one of TV’s most memorable characters?

Jay-Z and Beyoncé get married

Photo Credit: AP

APRIL 4 And they said it would never last.

'The Dark Knight' debuts

Photo Credit: Warner Bros. Pictures/Stephen Vaughan

JULY 18 The darkest of all of the Caped Crusader movies, made more poignant by the Oscar-worthy performance by the late Heath Ledger (he died in January) as The Joker.