Home Again started as an updated version of Mr Green's Reception, and was written during the late summer of 1914 by the brothers's famous uncle Al Shean. It so happened that uncle Al gave Harpo only a couple of lines, which is why Harpo from now on became a mute on stage. It was also the show the Marxes stuck with the longest. It opened in September 1914 and they were still performing it four years later. During the run of the show Herbert replaced Milton when the latter joined the army.

This song is mentioned on the sheet music of "Do not say goodbye", but it may not have been especially written for "Home Again". The composer Harry de Costa worked with Chico on other numbers of the show.