Born in the Bronx, New York City, to Russian Jewish immigrants, Berns contracted rheumatic fever as a child, an illness that damaged his heart and would mark the rest of his life, resulting in his early death. Turning to music, he found enjoyment in the sounds of his African American and Latino neighbors. As a young man, Berns danced in mambo nightclubs, and made his way to Havana before the Cuban Revolution.[1]:23

Shortly after his return from Cuba, Berns began a seven-year run from an obscure Brill Building songwriter to owner of his own record labels. He signed as a $50/week songwriter with Robert Mellin Music at 1650 Broadway in 1960. His first hit record was "A Little Bit of Soap", performed by the Jarmels on Laurie Records in 1961. Berns himself had a short-lived career as a recording artist, and in 1961, under the name "Russell Byrd", Berns scored his only Billboard Hot 100 appearance with his own composition, "You'd Better Come Home", which peaked at Number 50. That song would later be recorded by the Isley Brothers, and featured as the B-side of their 1962 single "Twistin' With Linda". Also in 1962, the Isley Brothers recorded "Twist and Shout" on Wand Records, written by Berns and Phil Medley. Berns also hit the charts in late 1962 with the Exciters' "Tell Him" on United Artists, and with Solomon Burke's "Cry to Me" on Atlantic Records. As an independent producer working with myriad record labels, Berns also made important records with Garnet Mimms ("Cry Baby") and Gene Pitney ("If I Didn't Have a Dime (to Play the Jukebox)").

Berns, who had a history of cardiac trouble, as a result of his heart being damaged from rheumatic fever contracted during childhood, died in his New York apartment of heart failure on December 30, 1967, aged 38. He was buried two days later, following a funeral service at Riverside Memorial Chapel on New York's 180 West 76th Street in Manhattan. His widow Ilene outlived her husband by nearly 50 years, passing away at the age of 73 on February 20, 2017.