Beta-galactoside-specific lectin 1 - P81446 (ML1_VISAL)

Protein Feature View of PDB entries mapped to a UniProtKB sequence

The A chain is responsible for inhibiting protein synthesis through the catalytic inactivation of 60S ribosomal subunits by removing adenine from position 4,324 of 28S rRNA. The B chain binds to cell receptors and probably facilitates the entry into the cell of the A chain; B chains are also responsible for cell agglutination (lectin activity). Inhibits growth of the human tumor cell line Molt4.
UniProt

Catalytic Activity

Endohydrolysis of the N-glycosidic bond at one specific adenosine on the 28S rRNA.
UniProt

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Validation Track