Significance of CNVRs by GWAS of ASDs in European-derived or African-derived populations.

The Manhattan plots show the −log10 transformed P-value of association for each CNVR along the genome. Adjacent chromosomes are shown in alternating red and blue colours. The regions discovered in Europeans (P≤0.0001) that replicated in Africans (P≤0.001) are highlighted with black arrows labelled by chromosome band. GWAS of 4,634 cases versus 4,726 controls in Europeans is shown on top and GWAS of 312 cases versus 4,173 controls in Africans is shown below.

Nodes of the network are labelled with their gene names, with red and green representing deletions and duplications, respectively, while grey nodes lack CNV data. Dark and light colours represent enrichment in cases and controls, respectively. The genes defining the network are shown as diamonds, while all other genes are shown as circles. Blue lines indicate evidence of interaction.