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This isn't something I've seen before, very strange. Mouse input to ArtRage is pretty standard so it's unlikely that you'll be able to change anything in ArtRage which would help. This could be caused by another application running in the background interacting with mouse input somehow.

Try closing down other programs and utilities ( check your taskbar at the bottom right ) before launching ArtRage to see if this makes any difference.

What sort of mouse are you using? Have you tried launching ArtRage without using the stylus at all, then using the mouse and does this change the behavior?