In fact, Simon et al (8) have shown in four phase II trials that celecoxib is effective in treating the signs and symptoms of osteoarthritis and rheumatoid arthritis, as well as showing that celecoxib is statistically significantly less likely than nonselective NSAIDs to cause gastric or duodenal erosions/ulcerations, (9) without any significant effect on platelet aggregation or thromboxane B2 levels.

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