The main building, the Richard Hoggart Building, was originally designed as a school (opened in 1844) by the architect
John Shaw, Jr (1803–1870). The former Deptford Town Hall Building, designed by Henry Vaughan Lanchester and Edwin Alfred Rickards, acquired in 1998, is used for academic seminars and conferences. In addition to this Goldsmiths has built several more modern buildings to develop the campus, including the RIBA award-winning Rutherford Building completed in 1997, the Ben Pimlott Building designed by Will Alsop and completed in 2005, and the Professor Stuart Hall Building (formerly the New Academic Building) which was completed in 2010.

The library, or the Rutherford Building, has three floors and gives students access to an extensive range of printed and electronic resources. The third-floor library is believed to house the largest collection of audio-visual material in the UK. Goldsmiths' students, like all other students in the University of London, have full access to the collections at Senate House Library at Bloomsbury in central London.

The seven-storey Ben Pimlott Building on New Cross Road, complete with its distinctive "scribble in the sky" (made from 229 separate pieces of metal) has become a signature of modern Goldsmiths. It contains studio and teaching space for the Department of Art, as well as housing the Goldsmiths Digital Studios[6] and the Centre for Cognition, Computation and Culture.[7]

The Professor Stuart Hall Building (formerly the New Academic Building), situated next to the green, is home to the Media and Communications Department and the Institute for Creative and Cultural Entrepreneurship (ICCE).[8] Facilities include a 250-seat lecture theatre, seminar and teaching rooms, as well as a cafe with outdoor seating.