The purpose of this concept note is to lay the foundations for the second phase of the United Nations Indigenous Peoples’ Partnership (UNIPP). UNIPP is acknowledged as an important mechanism to promote indigenous peoples’ rights in the outcome document of the World Conference on Indigenous Peoples as well as the System-Wide Action Plan on the Rights of Indigenous Peoples (SWAP), which specifically emphasizes UNIPP’s potential to advance UN system-wide coherence on indigenous issues at the country level. In order to identify the conditions required to maximize UNIPP’s transformational potential, this concept note looks back to the UNIPP experience to date (outlining relevant results and lessons learned) but also forward, to the measures that will be required for the Partnership to operate effectively in a new development landscape. Particular attention is paid to linkages with Agenda 2030 and the Paris Agreement under the UN Framework Convention on Climate Change.