A typical dietary supplement dosage of genistein for adults ranges from 8mg to 250mg twice daily. No established recommended supplement dosage exists. In several clinical trials up to 600mg were safely used in human test subjects, displaying no toxic side effects.

Metabolism

Interaction with Psychedelic Compounds

Some anecdotal reports indicate that whole kudzu extracts reduce the effects of psychedelics. Unlike whole kudzu which contains puerarin, a compound that interacts with 5-HT2C[15] and also may interact with either 5-HT1A or 5-HT2A receptors[14], genistein has not been shown to be active at 5-HT1A, 5-HT2A, or 5-HT2C receptors.