Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )

Length:

97

Sequences:

8338

Seq/Len:

85.96

HH_delta:

-0.049 (20Jul13)

GREMLIN Results:
Residue pairs sorted by strength in covariance:Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

i

j

Raw Score

Scaled Score

36_E

78_Y

2.47615

3.166

3_D

10_S

2.07491

2.653

52_S

77_G

1.94179

2.483

5_N

47_Y

1.94168

2.483

78_Y

82_Q

1.85583

2.373

7_S

54_R

1.71845

2.198

50_E

54_R

1.69942

2.173

60_K

75_V

1.65848

2.121

4_P

42_T

1.61617

2.067

18_D

66_N

1.61575

2.066

49_Q

53_Q

1.60129

2.048

87_N

92_G

1.56763

2.005

85_A

92_G

1.51698

1.940

53_Q

57_E

1.47644

1.888

18_D

62_Y

1.44914

1.853

42_T

93_R

1.42847

1.827

17_L

62_Y

1.28447

1.643

85_A

95_R

1.278

1.634

38_H

82_Q

1.15838

1.481

45_A

80_E

1.14316

1.462

60_K

64_V

1.10747

1.416

34_E

74_S

1.09362

1.398

62_Y

66_N

1.08236

1.384

86_S

92_G

1.07383

1.373

49_Q

81_S

1.06353

1.360

45_A

81_S

1.06046

1.356

57_E

60_K

1.04976

1.342

34_E

76_V

1.02243

1.307

9_L

62_Y

0.9903

1.266

64_V

70_P

0.93816

1.200

40_D

48_N

0.92616

1.184

16_Q

19_E

0.92369

1.181

69_P

72_R

0.92307

1.180

43_G

48_N

0.92182

1.179

60_K

73_I

0.9153

1.170

89_T

92_G

0.88887

1.137

9_L

13_S

0.88268

1.129

32_Q

74_S

0.87987

1.125

14_Q

62_Y

0.8787

1.124

35_I

60_K

0.84003

1.074

21_A

66_N

0.83837

1.072

3_D

6_S

0.83506

1.068

57_E

61_Q

0.82682

1.057

35_I

56_A

0.82624

1.057

11_P

14_Q

0.82282

1.052

13_S

16_Q

0.81614

1.044

62_Y

65_E

0.81393

1.041

61_Q

65_E

0.81369

1.041

4_P

40_D

0.80465

1.029

60_K

70_P

0.80339

1.027

57_E

75_V

0.79245

1.013

33_I

73_I

0.79207

1.013

36_E

76_V

0.79126

1.012

88_D

92_G

0.78175

1.000

41_S

93_R

0.77968

0.997

64_V

73_I

0.77394

0.990

1_Y

13_S

0.76865

0.983

47_Y

50_E

0.76617

0.980

54_R

57_E

0.73625

0.941

87_N

93_R

0.72801

0.931

20_L

24_L

0.72543

0.928

38_H

83_P

0.69597

0.890

17_L

59_V

0.69586

0.890

36_E

82_Q

0.68988

0.882

4_P

47_Y

0.68351

0.874

53_Q

77_G

0.65557

0.838

22_K

25_K

0.65393

0.836

41_S

87_N

0.6462

0.826

21_A

25_K

0.64611

0.826

56_A

77_G

0.64092

0.820

14_Q

18_D

0.63955

0.818

4_P

48_N

0.63845

0.816

7_S

58_A

0.63758

0.815

91_E

95_R

0.63207

0.808

56_A

75_V

0.63125

0.807

2_F

37_G

0.6229

0.797

18_D

22_K

0.61608

0.788

15_E

18_D

0.61303

0.784

19_E

22_K

0.60627

0.775

61_Q

64_V

0.60247

0.770

23_I

29_N

0.60014

0.767

7_S

51_L

0.59879

0.766

53_Q

75_V

0.58592

0.749

10_S

13_S

0.58049

0.742

21_A

63_L

0.57825

0.739

68_I

73_I

0.5741

0.734

84_L

95_R

0.57113

0.730

58_A

61_Q

0.54787

0.701

89_T

93_R

0.53957

0.690

68_I

72_R

0.53721

0.687

47_Y

51_L

0.53474

0.684

9_L

58_A

0.53328

0.682

39_T

48_N

0.52805

0.675

47_Y

80_E

0.52162

0.667

2_F

59_V

0.52117

0.666

50_E

53_Q

0.51777

0.662

25_K

69_P

0.51213

0.655

37_G

59_V

0.51151

0.654

41_S

83_P

0.51087

0.653

37_G

52_S

0.51016

0.652

1_Y

84_L

0.50273

0.643

86_S

89_T

0.49339

0.631

42_T

90_E

0.48724

0.623

85_A

93_R

0.48443

0.619

38_H

78_Y

0.48364

0.618

44_S

47_Y

0.48317

0.618

21_A

68_I

0.47854

0.612

21_A

62_Y

0.47637

0.609

4_P

43_G

0.47163

0.603

88_D

93_R

0.45767

0.585

48_N

80_E

0.45522

0.582

46_E

50_E

0.45068

0.576

90_E

93_R

0.44398

0.568

25_K

68_I

0.44048

0.563

30_K

72_R

0.44017

0.563

37_G

55_R

0.4374

0.559

20_L

23_I

0.43699

0.559

3_D

8_E

0.43017

0.550

16_Q

20_L

0.42983

0.550

53_Q

76_V

0.42578

0.544

19_E

23_I

0.42239

0.540

22_K

28_G

0.41283

0.528

7_S

50_E

0.40461

0.517

67_G

73_I

0.40201

0.514

41_S

88_D

0.40032

0.512

89_T

94_A

0.39773

0.509

5_N

43_G

0.39516

0.505

49_Q

79_G

0.39082

0.500

52_S

79_G

0.38851

0.497

15_E

19_E

0.38455

0.492

49_Q

52_S

0.38358

0.491

25_K

66_N

0.38077

0.487

64_V

67_G

0.3692

0.472

90_E

94_A

0.36363

0.465

24_L

72_R

0.36233

0.463

85_A

89_T

0.36217

0.463

12_E

15_E

0.36182

0.463

41_S

80_E

0.36053

0.461

Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.

HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits: Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)