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Abstract

Dietary lipids are reported to affect the blood pressure in both humans and experimental animal models with
hypertension. In the present study, 2-kidney, 1-clip (2K1C) hypertensive rats were treated with the modified fatty acid
tetradecylthioacetic acid (TTA) from the time of clipping or after hypertension was established. TTA treatment
attenuated the development of hypertension and reduced established 2K1C hypertension. The mRNA level of renin in
the clipped kidney and the plasma renin activity were markedly reduced, and the plasma angiotensin II level tended to
decrease after TTA treatment. In addition, TTA reduced the mRNA level of angiotensinogen in white adipose tissue.
Prevention of organ damage was demonstrated by normal urinary excretion of protein, maintained serum albumin, lower
heart weight, and clearly reduced vascular, glomerular, and tubulointerstitial damage in the nonclipped kidney. Renal
function was not affected as estimated by unchanged plasma creatinine. Furthermore, the serum levels of triacylglycerol
and cholesterol were reduced by TTA. The serum fatty acid composition was changed, resulting in a favorable increase
of oleic acid. However, the levels of all of the omega-3 fatty acids and of linoleic acid were reduced, and no change
was seen in the level of arachidonic acid, but the urinary excretion of 8-iso-prostaglandin F2 was declined. In
conclusion, TTA attenuated the development of hypertension, reduced established hypertension, and prevented the
development of organ damage in 2K1C rats, possibly by reducing the amounts of the vasoconstrictors angiotensin II and
8-iso-prostaglandin F2 and by inducing a favorable increase of oleic acid in serum.