During its 25 years’ history, ChemDiv has developed an arsenal of proprietary approaches towards fast, tractable and, even more importantly, novel chemistries. Examples include cascade addition-cyclization, multi-component reactions, one-pot syntheses, assemblies of macrolide-mimetics, spiro– medium- and large(macro) heterocyclic systems, isosteric replacements of aminoacids, di-/tri-peptides and many other unique protocols. Our teams of highly skilled scientists have formidable experience in addressing your synthetic, medicinal, building blocks, medicinal chemistry and compound optimization needs. It is this combination of a robust science, drug discovery expertise and transparent business/financial models that allowed us to offer Chemistry Systems on Demand™ approach. Specifically, we provide you with a set of our validated chemistries and respective scaffolds for your assessment followed by synthesis of large or small (target/purpose-focused) custom compound selections. Alternatively, we are happy to accommodate your chemical development ideas in order to convert them into libraries that uniquely suit your project needs.

CUSTOM SYNTHESIS

Several notable advantages offered by our synthetic team include:

Fast turn-around time in assessing project feasibility, cost and timing;

Management of a project by both science and business-focused professionals;

Development of your proprietary chemistries or library design based on our proprietary templates;

Estimated 10,000 scaffolds to choose from

Synthetic, scale-up or medicinal chemistry and target considerations for design

Computational and modeling assessment of target relevance, drug-/lead-like character

SYNTHETIC PATHWAYS DESIGN

Multiple considerations go into the design of templates, libraries and unique molecules. Naturally, ChemDiv takes into consideration and implements every specific consideration of our Clients. Additionally, key guidelines of modern drug-discovery including both chemical and biological aspects are involved:

At ChemDiv, we are always ready to incorporate your specific needs into every step of the design process.

SYNTHETIC PATHWAYS VALIDATION

Every chemical procedure is as good as its validation. At ChemDiv, we pay specific attention to this crucial step of chemical discovery. Once the protocol is suggested and adopted, our team of chemists evaluates reagents, conditions, feasibility, scaleability and safety in a multi-parameter validation matrix. If desired, our clients may be closely involved in either contributing to or monitoring of this process. In general, validation takes 2-4 weeks in order to gain information with regard to:

The general utility of the protocol or synthetic access to the molecule of interest

Tentative yield(s)

Feasible synthetic route(s) and potential for further detailed optimization(s)

As a rule of thumb, during the validation stage of larger compound sets corresponding to a specific template (>50-100 compounds), our team validates at least 10-20% of the chemical space to make our partners confident with regard to the anticipated outcome of larger studies.