<p>An evidence describes the source of an annotation, e.g. an experiment that has been published in the scientific literature, an orthologous protein, a record from another database, etc.</p>
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Proteomes - Mycobacterium sp. (strain KMS)

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Overview

Gene counti
<p>This is the total number of unique genes found in the proteome set, algorithmically computed. For each gene, a single representative protein sequence is chosen from the proteome. Where possible, reviewed (Swiss-Prot) protein sequences are chosen as the representatives.</p>

Proteome IDi
<p>The proteome identifier (UPID) is the unique identifier assigned to the set of proteins that constitute the <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a>. It consists of the characters ‘UP’ followed by 9 digits, is stable across releases and can therefore be used to cite a UniProt proteome.<p><a href='/help/proteome_id' target='_top'>More...</a></p>

Pan proteomei
<p>A pan proteome is the full set of proteins thought to be expressed by a group of highly related organisms (e.g. multiple strains of the same bacterial species).<p><a href='/help/pan_proteomes' target='_top'>More...</a></p>

Mycobacteria belong to the order Actinomycetales that are Gram-positive, acid-fast, pleomorphic, non-motile rods characterized by distinctive cell surface mycolic acid derivatives. They are obligate aerobes. This isolate belongs to a fast-growing group and actually has a coccus morphology, whereas members of the slow-growing group of Mycobacteria are notorious for causing human and animal diseases.

Mycobacterium KMS was isolated from soil in Libby, Montana, USA, the site of a former lumber and plywood mill. The soil is contaminated by polycyclic aromatic hydrocarbons (PAH), and KMS is one of several indigenous mycobacteria isolated from this site that are able to degrade high molecular weight PAH including pyrene, however this isolate cannot degrade benzo(a)pyrene. Other Mycobacteria from this site include strain MCS (MYCSS) and strain JLS (MYCSJ). Strain KMS mineralizes small- and large-ring PAHs, in contrast to other PAH-degrading microbes and thus offers possibilities for bioremediation of PAHs. The genome sequence of the Mycobacterium isolate KMS will permit comparisons with the genomes of pathogenic isolates, as well as an understanding of the pathway for PAH degradation and survival mechanisms in polluted conditions (adapted from genome.jgi-psf.org/myc_k/myc_k.home.html).

Mycobacteria have an unusual outer membrane approximately 8nm thick, despite being considered Gram-positive. The outer membrane and the mycolic acid-arabinoglactan-peptidoglycan polymer form the cell wall, which constitutes an efficient permeability barrier in conjunction with the cell inner membrane.