The team settled in its current location in the State College area in 2006 and became known as the "State College Spikes". After one season with the Cardinals in State College, the Spikes ended their affiliation and became the new Class A-Short Season affiliate of the Pittsburgh Pirates, starting in 2007 and ending in 2012. The Spikes will once again switch affiliations back to the Cardinals for the 2013 season.

The State College Spikes were founded in 1958 in Auburn, New York as the Auburn Yankees. The team played its home games at Falcon Park in Auburn from 1958–1980. For two decades, affiliated baseball was a mainstay in Auburn. After the Yankees, the Mets, Twins and Phillies all had affiliation agreements with the team. In 1978, however, the team did not have an agreement in place. Auburn fielded an independent team known as the Auburn Sunsets. Unaffiliated baseball remained in Auburn for the following two seasons, as well. The team changed its name to the Auburn Red Stars in 1979 and Auburn Americans in 1980. Erie-area businessmen Dave Masi and Joe Castelli propped up the Americans, then reached an affiliation agreement with the St. Louis Cardinals during baseball's winter meetings. They moved the team to Erie for the 1981 season.

The team was purchased by Albany businessman Joe Vellano and the team relocated to Bernie Arbour Memorial Stadium in Hamilton, Ontario, to become the Hamilton Redbirds. The team maintained its affiliation with the Cardinals and played in Hamilton from 1988 to 1992. In 1991, Vellano sold the Redbirds to a limited partnership headed by Barry Gordon and Marc Klee. Gordon and Klee planned to relocate the team to New Jersey where partner Rob Hillard was heading up management of a new stadium. The team spent a lame duck 1991 season in Hamilton, but in 1992, the team set the all-time record for winning percentage by a St. Louis Cardinals minor league team at .651, with a record of 56–20.

The team's relocation to Glens Falls welcomed back professional baseball in five years. The team that previously played in Glens Falls before the Redbirds was the Eastern League's Glens Falls Tigers which relocated to London, Ontario and are now based in Trenton, New Jersey as the Trenton Thunder. Former owner Jack Tracz managed the interim operation and the manager for the 1993 season was Steve Turco after a season in which they had. Despite only agreeing to play in Glens Falls for one season, the team led the league in attendance with 78,725 and the team went 37–40, third in the 4-team McNamara Division, but just 4 games behind the Pittsfield Mets.

The team completed its relocation to Augusta, New Jersey, which is located in Sussex County to become the New Jersey Cardinals despite having construction delays on the stadium and the apparent mismanagement by the stadium group which filed for Chapter 11 bankruptcy 120 days before the start of the season. The team still maintained its affiliation with the Cardinals. The new stadium opened on schedule in large part due to the ownership and management of the Cardinals which was headed by Gordon and Klee's general manager Tony Torre. The team played their home games at Skylands Park from 1994–2005. The team put together a 43–32 regular-season mark, and then defeated the Jamestown Jammers, 2 games to 1, and the Auburn Astros, 2 games to 0, to win the league title.

Over the next nine seasons, the team experienced only one more winning season, going 39–37 in 2002. While the team suffered through several losing seasons, they quietly established new standards for Minor League Baseball attendance. With the arrival of additional teams in the New York metropolitan area and further stadium mismanagement attendance, began to slip. The Cardinals drew a league-leading 142,417 fans in their inaugural season, following that up with 157,557 in 1995, but 115,342 in 2004. The team relocated again after the 2005 season and were replaced by Sussex Skyhawks of the independent Canadian-American Association of Professional Baseball. This team folded after the 2010 season, leaving Skylands Park vacant for the first time in the stadium's history.

In October 2005, the owners agreed to sell the New Jersey Cardinals to a group headed by the principal partners of the Class Double-A Altoona Curve of the Eastern League. This allowed for a professional team to share Medlar Field at Lubrano Park with the host Penn State Nittany Lions baseball team, on whose campus the park stands. After the sale of the team was complete, the New Jersey Cardinals were then relocated to State College to become the State College Spikes. The team's new logo was then unveiled as an young white-tailed deer. The team's new colors became Penn State navy blue, cardinal, old gold, and moonlight yellow. The team still maintained their affiliation with the Cardinals in its first season in State College, but on On September 21, 2006, the Spikes ended their affiliation with the Cardinals and became the new Class A-Short Season affiliate of the Pittsburgh Pirates, starting in 2007.[1]. In September 2012, the Spikes switched their affiliation from the Pirates back to the Cardinals.[1]

2013 was the first of 2-year deal with the St. Louis Cardinals. This would be the best year in the State College Spikes History to date with a winning season of 48–27 season. They were successful at home, with a strong 30-8 record. on the road was not so nice to them with a record of 18–19. If they were to make it to playoffs. They needed the home field advantage. They locked up the Pinckney Division over Jamestown Jammers who would make it to playoffs under the wildcard and what was very important Home field advantage. The Spikes would face the Jamestown Jammers for a 3-game Series for the right to play in the Championship game. They would lose the first game of the series and would win the next 2 that were at home and move into championship series against the Tri-City Valley Cats. Where they would win game 1 and return home only to lose and tie the series up, 1–1. The final game would see the Spikes jump out to a 1-run lead and have Tri-City answer that call with 4 runs. An amazing try in the bottom of the ninth with Mason Katz hitting a 2 run Home run to bring the score to 4–3 Tri-City but the State College Spikes would go 3 out with Cesar Valera going down swinging for the third and final out. Records were shattered with Jimmy Bosco outfielder hitting for the cycle, David Washington setting the single season record for home runs of 10 and 50 RBIs. Steven Ramos would win the Batting avg. race in the New York Penn League with a .341. This season would also see the Bull Penn have the lowest ERA in all of American Baseball Major League and Minor League. Thanks to the help of great pitchers of Mitch Harris, Kevin Herget, and Jacob Booden. The Spike would have multiple walk-off wins giving this team the nickname "cardiac kids" and a long list of multiple hit games and turning double plays. The State College Spikes hope to continue this winning ways in 2014

2014 Proved to be the start of a winning season. Most of 2013 Players moved up and a new Roster entered. One new player named Rowan Wick would belt a record 14 home runs out over the fences, breaking David Washington's record of 12 before being moved up to Single A Advanced. Jake Stone would wear the #32 and fallow David Washington's run of Grand Slams Belting one out of the park on July 4, the same day David Washington did. Alex Deloan would also join in the home run race hitting, 6 home runs. The State College Spikes team would s put Auburn Dubbledays down on July 25, by setting a new Single game run record with a score of 17–3 with the bottom third scoring 9 runs. The Team is currently chasing the Playoffs again with a 7-game lead over Williamsport Crosscutters as of July 25.

"We're not one of these ownership groups that demands a winner every single year, but we haven't even put playoff tickets on sale," Spikes general manager Jason Dambach said in June 2012. "We've never really even come close to the playoffs. "So the mandate has been put out there. We didn't have a good team last year, and so it really doesn't make any sense to re-sign with the Pirates until September, if we are to do that."[2] "We weren't mad about J.D.'s comments," Pirates president Frank Coonelly said.[3] State College executives say some phone calls, texts and emails were never returned.[4] Greenberg said the affiliation decision from the Spikes' standpoint had "zero" to do with winning and losing.[3] In September 2012, the Pirates offered State College a player development contract extension.[4] Spikes owner Chuck Greenberg and Coonelly appeared to reach an agreement.[4] However, Greenberg never received a return phone call from anyone with the Pirates—not owner Bob Nutting, nor Coonelly, nor GM Neal Huntington.[4] Huntington said that "relationship endings are not always pretty," and this one appears to fall somewhere in that category.[3]

The team name "Spikes" has a threefold meaning. The club's official logo depicts a young white-tailed deer, for whom a "spike" is an undeveloped antler, symbolic of a young team member who may develop into a Major League Baseball player. The name also refers to a railroad spike, similar to the way the name "Altoona Curve" commemorates the famous Horseshoe Curve on the Pennsylvania Railroad. Finally, baseball players have long worn shoes with spikes. The team's official colors are Penn State navy blue, cardinal, old gold, and moonlight yellow.