A patient of Acute lymphocytic leukemia with fever and neutropenia develops diarrhoea after administration of amoxicillin therapy, which of the following organism is most likely to be the causativeagent –

A

Salmonella typhi

B

Clostridium difficile

C

Clostridium perfringens

D

Shigella flexneri

Q. 7

A patient of Acute lymphocytic leukemia with fever and neutropenia develops diarrhoea after administration of amoxicillin therapy, which of the following organism is most likely to be the causativeagent –

o It is caused by alteration of normal bowel flora, which allows multiplication of clostridium difficle which releases several toxins that damage the mucosa of the bowel and promote excretion of fluid.

o It takes the form of an acute, nonspecific colitis, i.e. pseudomembranous colitis.

o Almost any antimicrobial may initiate this condition, but the drugs most commonly reported today are injectable cephalosporins and amoxi/ampicillin — Laurence 9th/e 212 o

Clindamycin, not commonly used in routine practice today, had an even greater propensity.

o Metronidazole is the DOC for pseudomembranous colitis and vancomycin is an alternative.

Q. 11

Which of the following antibiotic is used in the treatment of Clostridium difficile associated diarrhoea?

A

Ciprofloxacin

B

Metronidazole

C

Piperacillin

D

Clindamycin

Q. 11

Which of the following antibiotic is used in the treatment of Clostridium difficile associated diarrhoea?

A

Ciprofloxacin

B

Metronidazole

C

Piperacillin

D

Clindamycin

Ans.

B

Explanation:

Ans. is ‘b’ i.e. Metronidazole

o Metronidazole is the DOC for clostrdium difficle associated diarrhoea.

Clostridium difficle is typically associated with Inflammatory’ diarrhea and not ‘secretory’ diarrhea. Clostridium Difficle may rarely cause a secretory type of diarrhea, but it remains the single best answer ofexclusion.