I have a series of users that selected to only run Safe Macros when they opened up one of our dashboards. This is preventing one of the buttons in the dashboard from working. How can the user change their macro preference to run all macros and not just the safe ones?

Not quite sure if the plugin uses the settings.ini file too. Check if there's such a file in the users AppData folder (C:\Users\MyUserHere\AppData\Roaming\QlikTech\Qlikview) and set the values for the security override parameters to 1: