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In a not-too-distant future, a lethal virus sweeps across Europe, prompting the creation of quarantine refugee camps in the United States. Police officers Delon (Natasha Henstridge) and Lemieux (Christopher Lambert) learn of a grisly murder in the Boston camp and team up to investigate. Suspecting the ruthless killer is infected with the virus, the pair have just hours to stop him before he becomes contagious and infects the entire population.