A panel is an individual frame, or single drawing, in the multiple-panel sequence of a comic strip or comic book. A panel consists of a single drawing depicting a frozen moment.

Comic strips in daily newspapers typically consist of either four panels (Doonesbury, For Better or For Worse) or three panels (Garfield, Dilbert), all of the same size. In Asia, a vertical four-panel arrangement (yonkoma) is common in newspapers, such as with Azumanga Daioh. In a comic book or graphic novel, the shapes of panels and the number of panels on a page may vary widely.

The word panel may also refer to a cartoon consisting of a single drawing; the usage is a shortened form of "single-panel comic". In contrast to multi-panel strips, which may involve extended dialogue in speech balloons, a typical panel comic has only one spoken line, printed in a caption beneath the panel itself. Many panel comics are syndicated and published daily, on a newspaper page with other syndicated cartoons that are collectively known as comic strips. Major comic strips in panel format include The Far Side, Dennis the Menace, The Family Circus, Ziggy, Herman, and Ripley's Believe It or Not. In this context, panels are contrasted with the more common comic strip format, which consists of an actual "strip" of multiple drawings that tell a story in sequence.