Before Using

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of clozapine in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of clozapine in the elderly. However, elderly patients are more likely to have constipation, trouble passing urine, uncontrolled movements, or age-related liver, kidney, or heart problems, which may require caution in patients receiving clozapine. This medicine should not be used for behavioral problems in older adults with dementia.

Pregnancy

Information about this clozapine-oral-route

Pregnancy Category

Explanation

All Trimesters

B

Animal studies have revealed no evidence of harm to the fetus, however, there are no adequate studies in pregnant women OR animal studies have shown an adverse effect, but adequate studies in pregnant women have failed to demonstrate a risk to the fetus.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

Amifampridine

Cisapride

Dronedarone

Droperidol

Fluconazole

Ketoconazole

Mesoridazine

Metoclopramide

Nelfinavir

Pimozide

Piperaquine

Posaconazole

Saquinavir

Sparfloxacin

Terfenadine

Thioridazine

Ziprasidone

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Abiraterone Acetate

Alfuzosin

Amiodarone

Amoxapine

Amprenavir

Anagrelide

Apomorphine

Aprepitant

Aripiprazole

Armodafinil

Arsenic Trioxide

Asenapine

Astemizole

Atazanavir

Azithromycin

Balofloxacin

Bedaquiline

Bepridil

Besifloxacin

Boceprevir

Bosentan

Bupropion

Buserelin

Buspirone

Caffeine

Carbamazepine

Ceritinib

Chloroquine

Chlorpromazine

Cimetidine

Cinacalcet

Cinoxacin

Ciprofloxacin

Citalopram

Clarithromycin

Clobazam

Cobicistat

Conivaptan

Crizotinib

Cyclobenzaprine

Dabrafenib

Darunavir

Dasatinib

Deferasirox

Delamanid

Deslorelin

Dexamethasone

Diltiazem

Disopyramide

Disulfiram

Dofetilide

Dolasetron

Domperidone

Doxorubicin

Doxorubicin Hydrochloride Liposome

Efavirenz

Enoxacin

Enzalutamide

Erythromycin

Escitalopram

Eslicarbazepine Acetate

Ethinyl Estradiol

Etravirine

Famotidine

Fentanyl

Fingolimod

Flecainide

Flumequine

Fluoxetine

Fluvoxamine

Fosamprenavir

Fosphenytoin

Gatifloxacin

Gemifloxacin

Gonadorelin

Goserelin

Granisetron

Halofantrine

Histrelin

Hydromorphone

Hydroquinidine

Ibutilide

Idelalisib

Iloperidone

Imatinib

Indinavir

Itraconazole

Ivabradine

Lapatinib

Leuprolide

Levofloxacin

Lithium

Lomefloxacin

Lomitapide

Lopinavir

Lumefantrine

Mate

Mefloquine

Methadone

Methoxsalen

Metronidazole

Mexiletine

Mibefradil

Miconazole

Mifepristone

Milnacipran

Mitotane

Mizolastine

Modafinil

Montelukast

Moricizine

Morphine

Morphine Sulfate Liposome

Moxifloxacin

Nadifloxacin

Nafarelin

Nafcillin

Nalidixic Acid

Nefazodone

Nevirapine

Nilotinib

Norfloxacin

Octreotide

Ofloxacin

Omeprazole

Oxcarbazepine

Oxolinic Acid

Oxycodone

Oxymorphone

Paliperidone

Pasireotide

Pazopanib

Pazufloxacin

Pefloxacin

Peginterferon Alfa-2b

Pentamidine

Perflutren Lipid Microsphere

Perphenazine

Phenobarbital

Phenylpropanolamine

Phenytoin

Pipemidic Acid

Pixantrone

Prednisone

Procainamide

Prochlorperazine

Promethazine

Propranolol

Protriptyline

Prulifloxacin

Quetiapine

Quinidine

Quinine

Ranolazine

Regorafenib

Rifabutin

Rifampin

Rifapentine

Rosoxacin

Rufinamide

Rufloxacin

Salmeterol

Sertindole

Sertraline

Sevoflurane

Siltuximab

Sodium Phosphate

Sodium Phosphate, Dibasic

Sodium Phosphate, Monobasic

Solifenacin

Sorafenib

Sotalol

St John's Wort

Sunitinib

Suvorexant

Tacrolimus

Tapentadol

Tegafur

Telaprevir

Telavancin

Telithromycin

Terbinafine

Teriflunomide

Tetrabenazine

Thiabendazole

Ticagrelor

Ticlopidine

Tipranavir

Topiramate

Toremifene

Trazodone

Trifluoperazine

Trimipramine

Triptorelin

Umeclidinium

Vandetanib

Vardenafil

Vemurafenib

Verapamil

Vinflunine

Voriconazole

Zileuton

Zotepine

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

Grapefruit Juice

Tobacco

Using this medicine with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

Caffeine

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially: