Publication Venue

Atrial natriuretic peptide (ANP), via its cGMP-forming guanylyl cyclase-A (GC-A) receptor, is critically involved in the regulation of arterial blood pressure and intravascu-lar volume. To elucidate the role of the endothelial effects of ANP, we generated mice with conditional, endothelium (EC)-restricted ablation of the GC-A gene. Our observations in these… (More)