NFL Media Insider Ian Rapoport reported Amendola is almost certain to be ruled out because of the groin injury he suffered during the first half of Sunday's 23-21 win over the Buffalo Bills, according to a source informed of his injury. The fifth-year pro left the field against Buffalo before returning to the lineup, but Amendola wasn't present at the Patriots' walkthrough Tuesday, per NFL Media's Albert Breer.

Until Amendola returns, it's a significant loss for the Patriots' young offense. Amendola hauled in 10 catches for 104 yards in a gutsy showing against the Bills. Fourteen of Brady's 52 pass attempts were aimed at the wideout, including a critical 10-yard completion on the game's winning drive.

Kenbrell Thompkins also got 14 targets from Brady, but the rookie hauled in just four of them. Amendola was the difference-maker Sunday.