-The
dried thyroid gland of the sheep is triturated in the usual way or an
extract may be prepared from the fresh gland.

(The following paper on the effects of Thyroid was written by
Dr. F. G. hme, Roseburg, Oregon)

The

Thyroid, especially if used continually
or in large doses, causes the following symptoms :

1

. Elevation of
the temperature.

2

. Increase of the
heart's action and of the frequency and volume of the pulse, which,
however, is more compressible. Walking, even standing, after taking a
dose is apt to cause a feeling of faintness and even complete syncope.
The heart may become so weak that it cannot endure any over-exertion
without danger, even death may result.

3

. Shortness of
breath.

4

. Increase or
decrease of appetite, sometimes nausea, less frequently vomiting still
less diarrha.

5

. Improvement in
body nutrition generally, more complete absorption of nitrogenous food.
But later on nitrogen is excreted in excess of that taken in the food.

6

. Loss of weight.

7

. Increase of
sexual desire.

8

. Menses profuse,
prolonged or more frequent, rarely amenorrha.

9

. Increased
activity of the mucous membrane, kidneys and skin, which becomes moist
and oily, sometimes exfoliation of the epidermis.

10

. Rapid growth
of the skeleton in the young with softening and bending of those bones
which have no bear weight.

11

. A disease
closely resembling exophthalmic goitre. A cataleptic improved under
large doses of Thyroid, but when the dose of 75 grs. A day was reached, symptoms like those of
exophthalmic goitre developed with a pulse of 160, but no glandular swelling. When the Thyroid was discontinued the catalepsy
grew worse, the exophthalmic goitre better ; when resumed the
catalepsy better, the exophthalmic goitre worse.

A patient, while under

Thyroid treatment for myxedema, took, through a
misunderstanding, in eleven days nearly 3 ounces of the desiccated Thyroid, whereupon
tachycardia, pyrexia, insomnia tremor of the limbs, polyuria,
albuminuria, and glycosuria, in short, a disease similar to exophthalmic
goitre developed.