Development of tooth extraction wound infection 3 to 7 days after extraction

Estimated Enrollment:

120

Study Start Date:

February 2008

Estimated Study Completion Date:

December 2011

Estimated Primary Completion Date:

July 2011 (Final data collection date for primary outcome measure)

Intervention Details:

Other: Colgate Total Toothpaste

Toothbrushing with Colgate Total Toothpaste

Other Names:

triclosan

dentifrice

Other: Colgate Regular Toothpaste

Toothbrushing with Colgate regular toothpaste

Other Names:

fluoride

dentifrice

Detailed Description:

This study may provide evidence on the effect of triclosan containing dentifrice on oral bacteria and oral inflammation prior to third molar surgery, and on the incidence of inflammatory complications after the surgery. If proven effective, dentifrice containing triclosan may be recommended prior to tooth extractions and replace antibiotics and other antimicrobial products as a prophylactic procedure before oral surgery procedures.

Eligibility

Ages Eligible for Study:

18 Years to 35 Years

Genders Eligible for Study:

Both

Accepts Healthy Volunteers:

Yes

Criteria

Inclusion Criteria:

must include at least one mandibular third molar with partial or full bony impaction

no sign of active pericoronal (around the crown) infections

must have not taken antibiotics for any reason in the past 30 days

must be healthy and between 18 and 35 years of age

must be able to read and sign an informed consent

Exclusion Criteria:

Subjects with systemic diseases and pregnant or lactating women

Subjects with advanced periodontal diseases or having two or more untreated caries lesions

Subjects who cannot read and sign an informed consent

Subjects with signs of pericoronal infections

Contacts and Locations

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study.
To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below.
For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01292343