ABC Transporters and Cancer provides invaluable information on the exciting and fast-moving field of cancer research. Here, outstanding and original reviews are presented on a variety of topics. This volume covers ABC transporters and cancer, and is suitable for researchers and students alike.

Covers novel, state-of-the-art strategies in engineering and clinical analysis. Explores approaches for analyzing abdominal imaging, including lung, mediastinum, pleura, liver, kidney and gallbladder. Offers present and future applications as applied to the abdomen and thoracic imaging with the most world-renowned scientists in these fields.

In this book a team of leading experts come together to provide a comprehensive overview of modern imaging of the abdomen and pelvis, with detailed sections on both gastrointestinal and genitourinary imaging. Each chapter has an identical structure and focuses on a particular organ or organ system, allowing the reader to approach the field one topic at a time. Indications for a variety of imaging techniques and examination protocols are clearly described, and the imaging features of normal anatomy and pathologic entities are depicted in an abundance of high-quality images. Care is taken to consider all recent technical developments and new indications, and the diagnostic performance of different imaging modalities is carefully compared. It is anticipated that this book will come to be regarded as the standard work of reference on abdominal and pelvic radiology.

Provides transplant professionals with a step-wise approach to abdominal organ retrieval and bench surgery, illustrating complex anatomical situations and providing practice points and decision algorithms. A go-to reference for transplant surgeons, trainees and fellows, as well as for other professionals involved in abdominal organ transplantation.

Abdominal Ultrasound for Surgeons provides a comprehensive guide to the use of ultrasonography in surgical practice of abdominal diseases. The content is divided into three major sections focusing on basic principles of ultrasound, ultrasound anatomy and pathology of the abdomen, and employment of ultrasound of the abdomen in surgical practice. A final section is dedicated to the logistics of incorporating ultrasound into a surgical practice. The first section provides an introduction to the principles of ultrasonography focusing on ultrasound physics, equipment, and instrumentation. A detailed approach to the various scanning methods and image interpretation is demonstrated with illustrations, images, and video. The second section focuses on ultrasound anatomy of the abdomen. Each chapter demonstrates the normal and abnormal ultrasound anatomy of specific abdominal organ or organ systems (abdominal wall, liver, pancreas, biliary, stomach, anorectum, retroperitoneum, vascular) with illustrations and images. The current status and technique of endoscopic ultrasound of the upper and lower gastrointestinal tracks is addressed in this section. The third section provides a state-of-the-art review of the status of each major application of abdominal ultrasound in surgery. Topics range from trauma ultrasound and laparoscopic staging to techniques in ultrasound guidance and three-dimensional targeting. This section provides a comprehensive review of the employment of interventional, intraoperative, laparoscopic, transabdominal and endoscopic ultrasound. The fourth and last section addresses the practice aspects of incorporation of ultrasound into a surgical practice. Abdominal Ultrasound for Surgeons will serve as a very useful resource and guide for surgeons and students with little to some experience in ultrasound, including practicing surgeons, surgical fellows, and surgical residents.

The new edition of this leading volume in the Secrets Series® offers the very latest overview of surgical practice. A two-color page layout, question-and-answer approach, and a list of the "Top 100 Secrets" in surgery gives you the perfect concise board review or handy clinical reference, while updated coverage throughout equips you with all of the most current and essential knowledge in the field. Valuable pearls, tips, and memory aids make this the perfect resource for a fast surgical review or reference. Uses bulleted lists, tables, short answers, and a highly detailed index to expedite reference. Includes pearls, tips, and memory aids, making it perfect as a handy surgical review for board exams or clinical reference. Covers all of today's most common surgical procedures and techniques. Presents a "Controversies" section in many chapters that highlights the pros and cons of selected procedures and approaches. Features a compact trim size for enhanced portability.

Ingredients of the simplest cells (prokaryotes and the sizes of their contents) -- Bigger cells (eukaryotic cells and their contents) -- Hives of industry (a survey of intermediary metabolism) -- Delights of transport (how the cell's contents are moved around) -- As if standing still (cellular homeostasis and regulatory processes) -- Internal state and gene expression (transcription and its control) -- Sustaining and changing the internal state (the interrelationship between gene expression and the cell's current composition and functional state) -- Responding to the environment (signal processing, gene expression and internal state) -- The living state (a characterization of 'life') -- Stability and change in DNA (how genes can be altered) -- The spice of life (diversity, natural selection and symbiosis) -- Curriculum vitae (an outline history of life on Earth) -- The origin of life (some major ideas and unanswered questions) -- Other worlds (the possibility of extraterrestrial life) -- Intelligent behavior and brains (the biological meaning of "intelligence") -- Human evolution (human intelligence and the question of human uniqueness) -- Cells, brains and computers: towards a characterisation of mind.

This concise guide covers the evolution and expanding scope of hospital medicine and the variety of clinical, ethical and administrative situations a Hospitalist encounters. 500 questions on inpatient care, co-management of patients and hospital system management are provided with the goal of assessing clinical and academic competency. Questions feature actual cases with evidence-based solutions. Useful to physicians, house staff and advanced nurse practitioners, this up-to-date referenced learning text encompasses all aspects of hospital care.

Written in a succinct question and answer format, this comprehensive resource covers all areas of nephrology and common clinical scenarios. Nearly 1000 questions with detailed answers provide nephrology fellows, practicing nephrologists and clinicians a better understanding of nephrology and aid preparations for nephrology and internal medicine boards. Absolute Nephrology Review features the latest evidence and guidelines while fulfilling a critical need within the nephrology community.

Part 1. General Considerations -- 1. Global Burden of Surgical Disease and the Role of Academia -- 2. Promoting, Developing, and Sustaining Academic Global Surgery Programs.-3. Ethics in Global Surgery -- Part 2. Career -- 4. Preparing and Sustaining Your Career in Academic Global Surgery -- 5. Balancing Global Surgery with Traditional Career and Life Demands -- Part 3. Clinical -- 6. Guidelines and Parameters for Ideal Short-Term Interactions: Disaster Relief -- 7. How to Set Up for an Ideal Long Term Clinical Interaction -- Part 4. Research -- 8. Current Research Needs and Priorities -- 9. Research Methods Appropriate and Applicable to Global Surgery -- 10. Funding for Global Surgical Programs -- Part 5. Education -- 11. Developing Educational Opportunities for Trainees on Both Sides -- 12. The Role of Educational Research in the Global Setting -- Part 6. Resources -- 13. Tools Useful for the Academic Global Surgeon.

Attaining professional success and finding personal happiness in academic medicine is not an easy path, yet both are critical if the future is to be brighter through better science, better clinical care, better training, better responsiveness to communities, and better stewardship and leadership in the health professions. This concise, easy to read title consists of "mini" chapters intended as a resource to assist early- and middle-career physicians, clinicians, and scientists in understanding the unique mission of academic medicine and building creative, effective, and inspiring careers in a challenging field.

"Beyond simulation and algorithm development, many developers increasingly use MATLAB even for product deployment in computationally heavy fields. This often demands that MATLAB codes run faster by leveraging the distributed parallelism of Graphics Processing Units (GPUs). While MATLAB successfully provides high-level functions as a simulation tool for rapid prototyping, the underlying details and knowledge needed for utilizing GPUs make MATLAB users hesitate to step into it. Accelerating MATLAB with GPUs offers a primer on bridging this gap. Starting with the basics, setting up MATLAB for CUDA (in Windows, Linux and Mac OS X) and profiling, it then guides users through advanced topics such as CUDA libraries. The authors share their experience developing algorithms using MATLAB, C++ and GPUs for huge datasets, modifying MATLAB codes to better utilize the computational power of GPUs, and integrating them into commercial software products. Throughout the book, they demonstrate many example codes that can be used as templates of C-MEX and CUDA codes for readers' projects. Download example codes from the publisher's website: http://booksite.elsevier.com/9780124080805/ Shows how to accelerate MATLAB codes through the GPU for parallel processing, with minimal hardware knowledge -- Explains the related background on hardware, architecture and programming for ease of use -- Provides simple worked examples of MATLAB and CUDA C codes as well as templates that can be reused in real-world projects."--Provided by publisher.

This book is the first major work that addresses a core question in biomedical research: the question of acceptable risk. The acceptable level of risks is regulated by the requirement of proportionality in biomedical research law, which state that the risk and burden to the participant must be in proportion to potential benefits to the participant, society or science. This investigation addresses research on healthy volunteers, children, vulnerable subjects, and includes placebo controlled clinical trials.

McGraw-Hill, Users must create a personal profile in AccessMedicine using a non-mobile browser, and log into AccessMedicine with that username and password on the mobile device (optimized for): iPhone, Android, and BlackBerry Bold.

Since it was first published, Accident and Emergency Radiology: A Survival Guide has become the classic in-my-pocket-reference and an indispensable aid to all those who work in the Emergency Department. The core and substantial value lies in the step-by-step analytical approaches which help you to answer this question: "These images look normal to me, but . . . how can I be sure that I am not missing a subtle but important abnormality?" Ensure accuracy in reading and interpretation of any given image. Common sources of error and diagnostic difficulty are highlighted. Prevent mistakes. Pitfalls and associated abnormalities are emphasized throughout. Avoid misdiagnoses. Normal anatomy is outlined alongside schemes for detecting variants of the norm. Each chapter concludes with a summary of key points. Will provide a useful overview of the most important features in diagnosis and interpretation.Easily grasp difficult anatomical concepts. Radiographs accompanied by clear, explanatory line-drawings.

This book provides a state-of-the-art look at the applied biomechanics of accidental injury and prevention. The editors, Drs. Narayan Yoganandan, Alan M. Nahum and John W. Melvin are recognized international leaders and researchers in injury biomechanics, prevention and trauma medicine. They have assembled renowned researchers as authors for 29 chapters to cover individual aspects of human injury assessment and prevention. This third edition is thoroughly revised and expanded with new chapters in different fields. Topics covered address automotive, aviation, military and other environments. Field data collection; injury coding/scaling; injury epidemiology; mechanisms of injury; human tolerance to injury; simulations using experimental, complex computational models (finite element modeling) and statistical processes; anthropomorphic test device design, development and validation for crashworthiness applications in topics cited above; and current regulations are covered. Risk functions and injury criteria for various body regions are included. Adult and pediatric populations are addressed. The exhaustive list of references in many areas along with the latest developments is valuable to all those involved or intend to pursue this important topic on human injury biomechanics and prevention. The expanded edition will interest a variety of scholars and professionals including physicians, biomedical researchers in many disciplines, basic scientists, attorneys and jurists involved in accidental injury cases, and governmental bodies. It is hoped that this book will foster multidisciplinary collaborations by medical and engineering researchers, and academicians and practicing physicians for injury assessment and prevention and stimulate more applied research, education and training in the field of accidental-injury causation and prevention.

"A guide to the strange and often illogical world of neural function, 'The accidental mind' shows how the brain is not an optimized, general-purpose problem-solving machine, but rather a weird agglomeration of ad-hoc solutions that have been piled on through millions of years of evolutionary history. Moreover Linden tells us how the constraints of evolved brain design have ultimately led to almost every transcendent human foible : our long childhoods, our extensive memory capacity, our search for love and long-term relationships, our need to create compelling narrative, and ultimately, the universal cultural impulse to create both religious and scientific explanations. With forays into evolutionary biology, this analysis of mental function answers some of our most common questions about how we've come to be who we are." --book jacket.

The predisposition to many diseases is strongly influenced by the genome of an individual. However, the association between the genome and most diseases is not fully understood, so there is an ongoing effort to characterize these associations. One way to characterize disease-genome associations is by studying the familial and ancestral origin of individuals in the context of disease. This kind of study relies on the fact that individuals with shared origins tend to have genomes and phenotypes that are similar to one another. Detailed information regarding familial and ancestral origin is often unknown, however, it can be inferred computationally by examining the genome. Therefore, it is important that we have accurate methods to infer this information in order to facilitate disease-genome associations. In this dissertation, I describe the contributions I have made to accurately inferring the ancestry and relatedness of individuals based on their genomes. First, I describe my work on ALLOY, a method to infer the ancestral origin of segments of the genome based on a factorial HMM. Next, I present PARENTE, a method to infer which individuals in a group are related to one another by detecting genomic segments that are identical-by-descent (IBD) using an embedded likelihood ratio test. Finally, I present PARENTE2, an extension of PARENTE that incorporates linkage disequilibrium information and results in significantly higher accuracy.

"The primary aim of this innovative psycho-oncology educational initiative is to improve the delivery of palliative care by psychologists, social workers and spiritual care professionals through an intensive advocacy and leadership training program"--Website.

This book summarizes how the renin angiotensin system is implicated in the progression of atherosclerotic disease as well as of left ventricular dysfunction and reviews the action of angiotensin converting enzyme inhibitors and AT1 receptor antagonists on reducing morbidity and mortality in patients with left ventricular dysfunction or in those at high cardiovascular risk with preserved ventricular function. ACEi and ARBS in Hypertension and Heart Failure is a highly practical reference reviewing the evidence and providing a rationale for the appropriate use of RAS antagonists in cardiovascular diseases. It is written in an easy-to-follow format and with many illustrations to aid clarity and the assimilation of information. Each chapter is written by established authorities in their fields who are also experienced in explaining often complex concepts. The result is a unique book which is not only comprehensive but also clear and useful for the busy medical practitioner.

Nearly a million anterior cruciate ligament (ACL) injuries occur each year worldwide, causing long-term problems in the knee joint. This textbook examines the short- and long-term impacts of ACL injuries on the basis of hundreds of published studies. Risk factors for such injuries are explored using data from hypothesis-driven investigations, and possible causes of the higher risk of noncontact ACL injuries in female athletes are analyzed. Neuromuscular training programs shown to reduce the rate of these injuries in female athletes are described in step-by-step detail with the aid of numerous color photographs and video demonstrations. In addition, detailed descriptions are provided for rehabilitation programs to be used after ACL reconstruction in order to reduce the risk of a future injury.

"The ACL-Deficient Knee: A Problem Solving Approach, focuses on problem analysis and problem solving, as well as analyzing the possibility of prevention. In each chapter, the biomechanics, anatomy, etc. that are relevant to the topic are reviewed. There are chapters where highly specialized surgical techniques are presented (v. gr. double bundle reconstruction or meniscal transplant), as well as developing areas such as ACL tears in children, where we are finding a growing number of injuries due to the increase of sports at early ages."--publisher's website

Dermatologists commonly treat acne, which affects 40 to 50 million Americans each year and about 85 percent of all patients at some point in their lives. Dermatologists, primary care doctors, and pediatricians see these patients every day in practice. It is important to treat the skin effectively not only to reduce the risk of physical scarring, but also to address the negative psychosocial impact this disease carries. Improving the skin can improve self-confidence, interpersonal relationships, and performance in school or at work. Acneiform Eruptions in Dermatology is a practical, full-color guide to the differential diagnosis of acne vulgaris and the treatment of acne-like conditions. It is organized into sections by subtype of condition (e.g., infections, genetic syndromes, medication-caused) and includes a section of variants of acne that may be misdiagnosed. Within the sections, individual chapters discuss each variant of the condition and begin with a helpful bulleted summary of its defining clinical features. Extensive color clinical images appear throughout the book.

In 2014, the American Cancer Society Cancer Action Network (ACS CAN) analyzed coverage of cancer drugs in the health insurance marketplaces created by the Affordable Care Act (ACA) and found that transparency of coverage and cost-sharing requirements were insufficient to allow cancer patients to choose the best plan for their needs. In this updated analysis, we found that coverage transparency has improved somewhat since 2014, but significant barriers remain for cancer patients. To address these barriers, we provide nine recommendations to states and the U.S. Department of Health and Human Services to increase transparency of coverage and cost-sharing, ensure adequate access to medically necessary drugs via an exceptions process, make cost-sharing more predictable and affordable for patients, and monitor the marketplace for evidence of discrimination against persons with high-cost conditions such as cancer.

Emerging public health information suggests that to reach the U.S. Centers for Disease Control and Prevention's goal to improve health and fitness, prevent disease and disability, and enhance quality of life for all Americans through physical activity, we must create a culture that integrates physical activity into our daily lives. The ACSM American Fitness Index[tm] (AFI) program developed a valid and reliable measure of health and community fitness at a metropolitan level to: Provide community leaders with information to understand the personal, community, societal and environmental influences on physical activity and healthy eating; Develop strategies to promote physical activity at multiple levels of influence; and Take action through local community mobilization with the AFI Community Action Guide, health promotion partners and other best practices

Emerging public health information suggests that to reach the U.S. Centers for Disease Control and Prevention's goal to improve health and fitness, prevent disease and disability, and enhance quality of life for all Americans through physical activity, we must create a culture that integrates physical activity into our daily lives. The ACSM American Fitness Index[tm] (AFI) program developed a valid and reliable measure of health and community fitness at a metropolitan level to: Provide community leaders with information to understand the personal, community, societal and environmental influences on physical activity and healthy eating; Develop strategies to promote physical activity at multiple levels of influence; and Take action through local community mobilization with the AFI Community Action Guide, health promotion partners and other best practices

The purpose of the The Active Female: Health Issues Throughout the Lifespan, 2nd Edition is twofold: (1) to increase the awareness of wellness and fitness issues for active females and their family members; and (2) to provide an avenue for medical practitioners, allied health professionals, health educators, and certified individuals in sports medicine to gain critical, updated knowledge of a field specific to active females. Part I of the book offers a foundation to help the reader understand the interrelationship among body image concerns, the female reproductive cycle, and musculoskeletal anatomy/physiology of females that makes their health risks and concerns unique. Reproductive health is discussed by a prominent researcher in reproduction/endocrinology. An overview of the Female Athlete Triad which is a syndrome of three interrelated conditions (isordered eating, menstrual disturbances and bone loss) is presented in Part II. Physicians and certified professionals in sports medicine discuss the individual components of the triad, relating not only to the athletic female but also to the recreationally active woman throughout the lifespan. In Part III, Prevention and management of common musculoskeletal injuries is addressed by a female orthopedic surgeon who sub-specializes in treating female athletes. Finally, appropriate exercise and nutritional guidelines for active females are discussed in Parts IV-V of the book by certified professionals and licensed physicians in sports medicine. An invaluable addition to the literature, The Active Female: Health Issues Throughout the Lifespan, 2nd Edition will be of great interest to physicians, allied health care practitioners, medical/other wellness educators, and students who are interested in advancing women's health issues. Sports medicine specialists, family practitioners, gynecologists, team physicians, residents in sports medicine, athletic trainers, health educators, nurses, physicians assistants, physical therapists, sport psychologists, counselors, athletic trainers, and other members of the sports medicine team should also find this title of significant interest.

Active Shooter events are becoming increasingly more common, and while there have been recommendations on how to respond since 2008, these guidelines focused on schools, government, and business settings. In January of 2014, the HPH SCC released "Active Shooter Planning and Response in a Healthcare Setting". That draft document was the first comprehensive guidance written for healthcare facilities to prevent, respond to, and recover from an active shooter event. This updated document expands upon the initial draft document to include law enforcement tactics and integrated medical and mental health response.

"The Chinese are known to have practiced acupuncture for approximately 2,000 years. Designed specifically for health care practitioners, this book demystifies acupuncture and explains it in anatomical terms. New emphasis is made to differentiate traditional acupuncture in Oriental medicine from scientific acupuncture, which is based entirely on medical sciences. This edition is completely updated and presents the most current research. New material includes information on how to quantify pain and a new way to define acute and chronic pain"--Provided by publisher.

Acupuncture for Pain Management is intended as the premier resource for learning the fundamentals of the art of medical acupuncture. Edited by top pain medicine specialists at Harvard and UCLA, and based on their popular annual workshop at the American Society for Anesthesiologists, the book is the perfect synthesis of Western and Chinese medicine. Anesthesiologists, pain medicine specialists, primary care physicians, osteopaths, neurologists, psychiatrists, physical medicine and rehabilitation specialists, and other health professionals looking to add acupuncture to their repertoire will benefit from the concise and practical approach of the book. Features: Each individual meridian discussed in detail acupuncture for 25 clinical conditions, including headache, menstrual pain, low back pain, insomnia, and more. Aimed at acupuncturists as well as practitioners who want to add acupuncture to their clinical armamentarium.

Neglected finger injuries may lead to chronic lesions that often have detrimental consequences for the practice of a ball sport, whether at a recreational level or at the top athlete level. The initial injury management is crucial. Depending on the type and the severity of the lesions, different people may get involved: the players themselves or their entourage, physiotherapists, club doctors, emergency physicians, family doctors, sports doctors or hand surgeons. Treatment is usually conservative: the long fingers require rapid mobilization to prevent stiffness and contrary to that, the thumb requires stability. Surgery may be necessary to reach these goals especially for athletes, because of the demands of their sport. Chronic lesions are also in part related to repeated trauma, requiring specialized long-term multidisciplinary treatment. They can often lead to the end of a sporting career, but also may limit the functionality of the fingers at the time of conversion.

This pocket guide is a single-volume source of the most common and important formulas and laboratory values used in the daily practice of acute care and critical care medicine. Information is presented in outline format and as tables, graphics, and algorithms to facilitate quick look up. Acute and Critical Care Formulas and Laboratory Values is designed to help clinicians interpret clinical data, apply formulas, understand laboratory values, and integrate this information with their knowledge of pathophysiology to promote the delivery of evidence-based care. Essential formulas and laboratory values. Multiple ways to derive a value, where appropriate. Non-clinical formulas useful for understanding physiologic concepts or that underlie diagnostic tests or clinical measurement.

"Describes the use of hemodiafiltration to inhibit the cytokine storms which cause serious organ damage in patients with septic shock. Moreover, the technical construction of the blood purification system, which includes various machines, devices, membranes, fluids, etc., is explained in detail. Finally, leading experts discuss the concept of continuous renal replacement therapy as the standard care in critically ill patients with severe acute kidney injury."--Website.

Acute Coronary Syndromes-a Companion to Braunwald₂s Heart Disease-covers the state-of-the-art scientific and clinical information you need to rapidly evaluate and manage acute coronary syndromes. Dr. Pierre Theroux and his team of expert contributors present advances in diagnostic and imaging techniques such as biomarkers, nuclear cardiology, echocardiography, and multislice CT; secondary prevention; and new antiplatelet, anti-ischemic, and gene therapies. Tap into the most definitive knowledge available from one of the leading experts in the field and a stellar cast of contributors. Understand the special considerations for the care of acute coronary syndromes in the emergency department and the coronary care unit. Effectively handle the treatment of special populations and chronic patients thanks to coverage of these challenges.

This practical guide provides the reader with answers to important clinically relevant questions regarding the evaluation and management of acute kidney injury (AKI). All aspects of critical care nephrology are covered, from pathophysiology and diagnosis to prevention and treatment. The questions considered relate to a wide range of issues, such as: How do I diagnose AKI? How can I protect the kidney in clinical practice? How do I manage patients with AKI? When should I initiate and how do I perform renal replacement therapy (RTT)? Which type of RTT is most appropriate for my patient? Should I give specific nutrients? In addition to providing practical guidelines and treatment algorithms, the book includes calculators for continuous RRT and anticoagulant dosing. The authors are internationally renowned experts in the fields of Intensive Care Medicine and Nephrology, and all contributions are written in a clear and concise style and have been peer reviewed. Acute Nephrology for the Critical Care Physician will serve as a very useful source for intensivists, internists, anesthesiologists, and nephrologists involved in the management and treatment of critically ill patients at risk of or affected by AKI.

This book provides recommendations for evaluation and therapy in the area of acute pediatric neurology; these are presented didactically with frequent use of illustrations and algorithms. Chapters in the first part of the book discuss presenting symptoms of acute neurological conditions. The second part of the book covers major areas of acute pediatric neurology and each of these chapters has three key elements: description of presenting symptoms; recommended assessments; and recommended interventions. Acute Pediatric Neurology provides an accessible, clinically focused guide to assist physicians in the emergency ward or intensive care unit in decisions on diagnosis and therapeutic interventions in all major acute pediatric neurological diseases.

Neural plasticity is high during developmental critical periods, then declines by adulthood. Here by acutely disrupting PirB function at different ages, we show that Paired immunoglobulin like receptor B (PirB) actively restricts plasticity both during and after the critical periopd. Chapter 1 introduces ocular dominance (OD) plasticity as a model of circuit and synaptic change, and presents a review of the literature on the study of mechanisms of OD plasticity, critical period timing, and manipulations that can alter plasticity later in life. Chapter 2 presents an overview of the methodological approaches used. PirB function was disrupted with temporal precision via either a conditional PirB allele or by minipump infusion of a soluble PirB ectodomain into mouse visual cortex. Chapter 3 details the effects of disrupting PirB function on plasticity in healthy animals. OD plasticity is enhanced not only during the critical period, but also when PirB function is disrupted in adulthood. The effects of adult deletion can occur even when PirB is only lost in excitatory neurons of the forebrain. Acute blockade of PirB for 10 days after the close of the critical period increases spine density on apical and basolateral dendrites of Layer 5 pyramidal neurons. Chapter 4 presents a proof of concept for therapeutic disruption of PirB function in cases of neurological dysfunction and disease. Long term monocular deprivation (LTMD) during the critical period leads to a lasting loss of vision in the deprived eye and to a decrease in dendritic spine density that does not recover even with subsequent binocular vision. However, acute blockade of PirB following LTMD allows for full recovery of spine density. MeCP2308/y mice, a mouse model of Rett Syndrome (a syndromic autism), were found to have increased MHC Class I expression and a concurrent loss of OD plasticity during the critical period, which can be rescued by acute blockade of PirB. Taken together, these results imply that mechanisms for enhanced structural and functional plasticity are present in adult visual cortex but are actively repressed by PirB. By removing negative regulators such as PirB, we show that it is possible to engage these endogenous mechanisms to facilitate recovery from otherwise irreversible effects of dysfunctional development. Our observations suggest that similar manipulations may be useful in other situations where restoring synaptic plasticity and increasing spine density have therapeutic value.

Approach to the patient with neurologic disease -- Special techniques for neurologic diagnosis -- Motor paralysis -- Abnormalities of movement and posture caused by disease of the basal ganglia -- Incoordination and other disorders of cerebellar function -- Tremor, myoclonus, focal dystonias, and tics -- Disorders of stance and gait -- Pain -- Other somatic sensation -- Headache and other craniofacial pains -- Pain in the back, neck, and extremities -- Disorders of smell and taste -- Disturbances of vision -- Disorders of ocular movement and pupillary function -- Deafness, dizziness, and disorders of equilibrium -- Epilepsy and other seizure disorders -- Coma and related disorders of consciousness -- Faintness and syncope -- Sleep and its abnormalities -- Delirium and other acute confusional states -- Dementia and the amnesic (korsakoff) syndorme with comments on the neurology of intelligence and memory -- Neurologic disorders caused by lesions in specific parts of the cerebrum -- Disorders of speech and language -- Fatigue, asthenia, anxiety, and depressive reactions -- The limbic lobes and the neurology of emotion -- Disorders of the autonomic nervous system, respiration, and swallowing -- The hypothalamus and neuroendocrine disorders -- Normal development and deviations in development of the nervous system -- The neurology of aging -- Disturbances of cerebrospinal fluid and its circulation, including hydrocephalus, pseudotumor cerebri, and low-pressure syndromes -- Intracranial neoplasms and paraneoplastic disorders -- Infections of the nervous system (bacterial, fungal, spirochetal, parasitic) and sarcoidosis -- Viral infections of the nervous system chronic meningitis, and prion diseases -- Cerebrovascular diseases -- Craniocerebral trauma -- Multiple sclerosis and allied demyelinating diseases -- Inherited metabolic diseases of the nervous system -- Developmental diseases of the nervous system -- Degenerative diseases of the nervous system -- The acquired metabolic disorders of the nervous system caused by nutritional deficiency -- Alcohol and alcoholism -- Disorders of the nervous sytem caused by drugs, toxins, and other chemical agents -- Diseases of the spinal cord -- Electrophysiologic and laboratory aids in the diagnosis of neuromuscular disease -- Diseases of the peripheral nerves -- Diseases of the cranial nerves -- Principles of clinical myology: diagnosis and classification of disease of muscle and neuromuscular junction -- The infectious and inflammatory myopathies -- The muscular dystrophies -- The metabolic and toxic myopathies -- The congenital neuromuscular disorders -- Myasthenia gravis and related disorders of the neuromuscular junction -- Ion channel disorders: the periodic paralyses and hereditary nondystrophic myotonias (channelopathies) -- Disorders of muscle characterized by cramp, spasm, pain, and localized masses -- The anxiety neuroses, hysteria, and personality disorders -- Depression and bipolar disease -- The schizophrenias and paranoid states.

Organismic evolution involves both selective and neutral forces, although their relative contributions are often unknown. This thesis proposes novel statistical methods for analyzing genetic data from a variety of organisms, including yeast, Mycobacterium tuberculosis, and humans. The chapters of this thesis provide complimentary perspectives on the relative roles of selection and neutrality, from the molecular to the population level, and present various statistical tools for genetic data analysis. Chapter 2 proposes a maximum-likelihood based method with which to classify and identify interactions, or epistasis, between pairs of genes. Chapter 3 details a study of genetic data from Mycobacterium tuberculosis isolated from human Aboriginal Canadian communities; our analyses suggest that the bacterium spread to these communities via the Canadian fur trade in the 18th and 19th centuries. Chapter 4 discusses the detection of signatures of natural selection in the genomes of 12 diverse African human populations, and proposes novel considerations for identifying biological functions under selection and for comparing signals of selection between populations. Finally, Chapter 5 details the inference of the genetic basis and evolutionary history of light skin pigmentation and short stature in the genetically diverse [not equal to sign] Khomani Bushmen of the Kalahari Desert of South Africa, believed to be one of the world's most ancient human populations. These chapters emphasize that a more complete understanding of the evolutionary history of humans and other organisms requires not only the consideration of neutral and selective processes, but also both phenotypic and genetic information. The statistical methods and approaches presented in the following chapters have the potential to improve inferences of natural selection and demography from genetic data, as well as provide insight into the relative roles of both.

When developing new drugs, Phase I and II trials are commonly conducted to determine the dose of the new treatment in preparation for the subsequent confirmatory Phase III trial. However, because these early-phase trials usually do not have large enough sample sizes to decide which dosage level or treatment regimen is the best, several of them may arise as candidates for the confirmatory Phase III trial. Conventional fixed sample size designs that carry out all the treatment arms of interest are obviously expensive. Therefore, the pharmaceutical industry is increasingly interested in adaptive designs that can use information acquired during the course of the trial to update certain of the design features. In this thesis we explore several existing designs and discuss their pros and cons. We then propose one that shares the flexibility of Bayesian adaptive designs, while still being able to maintain the frequentist type I error probability. We develop an asymptotic theory for efficient outcome-adaptive randomization schemes and optimal stopping rules. Our approach consists of developing asymptotic lower bounds for the expected sample sizes from the treatment arms and the control arm, and using generalized sequential likelihood ratio procedures to achieve these bounds. These allow us to allocate patients and study resources efficiently by using outcome-adaptive randomization schemes, or by arm suspension/selection if fixed randomization is used. We also derive an adaptive test with a p-value that can be evaluated by Monte Carlo simulation based on an ordering scheme of the sample space. We then show that the approach can also be applied to the closely related problem of multi-stage testing of multiple hypotheses.

"Preface External-beam radiotherapy has long been vexed by the simple fact that patients can (and do) move during the delivery of radiation. The most elegant and forward-looking solution to this reality is to actively adapt the radiation delivery process to the patient's natural movements. Recent advances in imaging and beam delivery technologies have now made this solution a practical reality. The purpose of this book is to present to researchers and clinical practitioners in radiation therapy an overview of the current and prospective state of the art in motion-adaptive radiation therapy. It presents technical reviews of each of the contributing elements of a motion-adaptive system (including target detection and tracking, beam adaptation, and patient realignment), discusses treatment planning issues that arise when the patient and internal target are mobile, describes several integrated motion-adaptive systems that are in clinical use or at advanced stages of development, and concludes with a review of the system control functions that must be an essential part of any therapy device that operates in a near-autonomous manner with limited human interaction. From these chapters, the reader will hopefully gain not only an understanding of the technical aspects and capabilities of motion adaptation but also practical clinical insights into planning and carrying out various types of motion-adaptive radiotherapy treatment"--Provided by publisher.

Adaptive Optics for Biological Imaging brings together groundbreaking research on the use of adaptive optics for biological imaging. The book builds on prior work in astronomy and vision science. Featuring contributions by leaders in this emerging field, it takes an interdisciplinary approach that makes the subject accessible to nonspecialists who want to use adaptive optics techniques in their own work in biology and bioengineering.Organized into three parts, the book covers principles, methods, and applications of adaptive optics for biological imaging.

This book attempts to "bridge the gap between the explosion of neuroscientific and behavioral knowledge in the past three decades and treatment delivery in clinical practice. As such, it should fulfill the role of a comprehensive textbook that integrates addiction medicine from its scientific underpinnings to the treatment of patients in clinical settings"--Preface, p. vii.

What is addiction neuroethics and why does it matter? -- Brain Imaging in Addiction -- Molecular Neuroscience and Genetics -- Treating Opioid Dependence with Opioids: Exploring the Ethics -- Addiction Neuroscience and Tobacco Control -- Emerging Neurobiological Treatments of Addiction: Ethical and Public Policy Considerations -- Technical, Ethical and Social Issues in the Bioprediction of Addiction Liability and Treatment Response -- Autonomy, Responsibility and the Oscillation of Preference -- Consent and Coercion in Addiction Treatment -- Toward a Lay Descriptive Account of Identity in Addiction Neuroethics -- The Impact of Changes in Neuroscience and Research Ethics on the Intellectual History of Addiction Research -- The Diction of Addiction at the Intersection of Law and Neuroscience -- Social Epistemology: Communicating Neuroscience -- Population Approaches to Alcohol, Tobacco and Drugs: Effectiveness, Ethics and Interplay with Addiction Neuroscience -- Legal Regulation of Addictive Substances and Addiction -- Investment and Vested Interests in Neuroscience Research of Addiction: Ethical Research Requires More than Informed Consent -- Private and Public Approaches to Addiction Treatment: Evidence and Beliefs.

Addiction Recovery Management: Theory, Research, and Practice is the first book on the recovery management approach to addiction treatment and post-treatment support services. Distinctive in combining theory, research, and practice within the same text, this ground-breaking title includes authors who are the major theoreticians, researchers, systems administrators, clinicians and recovery advocates who have developed the model. State-of-the art and the definitive text on the topic, Addiction Recovery Management: Theory, Research, and Practice is mandatory reading for clinicians and all professionals who work with patients in recovery or who are interested in the field.

This brief offers strategies for service providers in public or assisted housing communities to develop strong home visiting services for highly distressed families battling challenges such as depression, substance abuse, or domestic violence. It also provides information on one strategy in particular--the SCRIPT model--that gives concrete instructions for better serving families' mental health and other needs in home visiting programs. The brief also offers insights into how the model's framework could be adapted to allow local communities to respond to their community's particular needs, challenges, and contexts.

"While there is a wealth of published information on addiction medicine, the psychological aspects of alcohol abuse, and behavioral medicine with regard to addiction, virtually none of the existing resources were written with the primary care provider in mind. Addressing Unhealthy Alcohol Use in Primary Care is a handy reference for primary care clinicians who are confronted by patients with these problems daily, and who wish to successfully address these issues in their practice. Focusing on the literature and science relevant to practicing providers, this book covers the range of interventions appropriate for this setting. Topics include assessment, brief counseling interventions, pharmacotherapy, referrals to both specialty care and Alcoholics Anonymous (and other self-help programs), psychiatric comorbidity and other drug use, and other information specific to the needs of the primary care clinician. The vast majority of people with health risks and consequences related to alcohol use receive little to no attention from healthcare, despite the fact that alcohol is a leading cause of early preventable death. This book is a guide to identifying and addressing unhealthy alcohol use in hopes of improving the lives of patients."--publisher's website

ADHD in Adults: A Practical Guide to Evaluation and Management is the product of a unique collaboration of international specialists. This volume offers easy-to-read guidance, and includes checklists, rating scales and treatment planning tools. It was designed for a broad audience of caregivers working in diverse settings, including psychiatrists, social workers, primary care physicians, nurse specialists and psychologists. The authors are highly acclaimed clinicians, investigators and educators. They offer step-by-step guidance for implementation of best practices, drawing from clinical research and their experience treating thousands of patients. They cover diagnosis, treatment planning, and state-of-the-art application of pharmacology, psychotherapy, skill-building, family system and environmental interventions - for both simple and complex cases. The scales and worksheets in this Guide were developed to efficiently facilitate assessment and management. The Editor is an international leader in the field from the Clinical and Research Program in Adult ADHD at Massachusetts General Hospital (MGH) and Harvard Medical School, which has made pioneering and highly cited contributions to the understanding of ADHD. This Guide is a definitive, indispensable resource for all health providers who wish to optimize their approach to adult patients with ADHD.

Poor adherence to therapy is one of the main obstacles to treatment effectiveness in schizophrenia. It is the main determinant of relapse, hospitalization, symptom persistence, and poor psychosocial functioning and outcome. Adherence to treatment is affected by various factors related to the disease characteristics, to the patient him- or herself, to the treatment, and to the therapeutic relationship. Some of these factors are modifiable, and both pharmacological and non-pharmacological strategies have been developed for this purpose.This book addresses the different aspects of adherence to treatment in schizophrenia and related disorders in a systematic but easy-to-use manual format. Chapters focus on a full range of issues, including pharmacological and non-pharmacological strategies to enhance adherence and continuity of care, relevant psychological factors, the importance of the patient-doctor relationship, and the need for an alliance with other care-givers. Adherence to Antipsychotics in Schizophrenia will be an invaluable asset for all who are involved in the care of patients with schizophrenia.

Adhesion molecules are a family of proteins located on the cell surface and are involved in cell-to-cell or cell-extracellular matrix binding. They have a role in maintaining the cellular integrity of tissues and the functional viability of organs. In many diseases the normative features of adhesion molecules are perturbed. Thus, understanding how adhesion molecules behave in health and disease is a key step in the advancement of science and health in general. In the first part of the hook, chapters cover the structure and classification of adhesion molecules, immunohistochemical localization, junctional and inflammatory adhesion molecules and molecular imaging. The other four parts of the book cover adhesion molecules in relation to signalling pathways, gene expression, arginine, stem cells, neutrophil migration, leukocytes, decompression sickness, ischemia reperfusion injury, diabetes, obesity, metabolic syndrome, weight loss, hypoxia, kidney disease, smoking, osteoprotegerin, tumors, biointormatics, high-throughput technologies, chemotherapy, hematopoiesis, lipoproteins, fatty acids, atrial fibrillation and heart disease, brain and dementia. The book is an essential book for research scientists, pathologists, molecular biologists, biochemists or cellular biochemists, clinicians, health care professionals, general practitioners as well as those interested in disease in general.

Adipocytokines provide the circuitry by which adipose tissue communicates among its component cells which include adipocytes, stromal cells, immune cells and vascular elements, with adipose tissue depots in other locations throughout the body and with other tissues in order to regulate physiologic processes of energy intake, utilization, and distribution. Since disturbances, both qualitative and quantitative, in adipocytokine function contribute significantly to many of the comorbidities associated with obesity, including diabetes, cardiovascular disease and cancer, this volume, which discusses most of the major adipocytokines independently and collectively and their roles in normal and pathologic processes, should be useful to all individuals seeking a deeper understanding of these processes. Moreover, it provides a valuable complement to the series on Energy Balance and Cancer, in which each volume is focused on a specific aspect of this process, which now constitutes an expanding problem as the obesity pandemic continues and more of the population reaches the age where cancer is most prevalent. This volume should provide a valuable resource to all clinicians and scientists engaged in caring for susceptible patients and in exploring the relation between energy balance and cancer as well as an important platform to providing the background for research development.

The field of adipose tissue biology has been expanding at a very rapid pace in the last few years. Numerous advances have been made since publication of the first edition of this book, in terms of basic adipocyte biology, understanding of the determinants of obesity, distribution of body fat and weight loss, as well as the mechanisms linking excess adiposity to various co-morbidities. Adipose Tissue and Adipokines in Health and Disease, Second Edition contains updated chapters from the previous volume but as the field has evolved, some areas covered in the first edition have been refocused to address the new knowledge. The volume is divided in four sections: the first two deal with basic adipose tissue and adipokine biology, while the last two address the problem of obesity and alterations in adipose tissue function from an epidemiological and clinical standpoint. The chapters are written by experts in their fields and include the most up to date scientific information. Adipose Tissue and Adipokines in Health and Disease, Second Edition is a useful resource for physicians interested in adipose tissue biology and basic scientists who want to know more about applied aspects of the field. The book targets endocrinologists, residents and fellows, internists, nutritionists and general practitioners who are exposed to an ever-expanding obese population.

Drs. Paul L. Kaufman, Albert Alm, Leonard A Levin, Siv F.E. Nilsson, James Ver Hoeve, and Samuel Wu present the 11th Edition of the classic text Adler's Physiology of the Eye, updated to enhance your understanding of ocular function. This full-color, user-friendly edition captures the latest molecular, genetic, and biochemical discoveries and offers you unparalleled knowledge and insight into the physiology of the eye and its structures. A new organization by function, rather than anatomy, helps you make a stronger connection between physiological principles and clinical practice; and more than 1,000 great new full-color illustrations help clarify complex concepts. You can also access the complete contents online at www.expertconsult.com. Deepen your grasp of the physiological principles that underlie visual acuity, color vision, ocular circulation, the extraocular muscle, and much more.

This concise, evidence-based resource covers all of today₂s need-to-know information to quickly and effectively diagnose and manage common adolescent conditions ... in an exceptionally user-friendly format. Because it's so compact, clinically oriented, and easy to read, Adolescent Medicine: The Requisites in Pediatrics is an ideal study tool as well as a convenient reference for practice. Includes detailed discussions on special health issues, common medical problems, sexual and reproductive health, behavioral problems, and the transition to adult health care to help you gain a better understanding of the unique needs of the adolescent patient. Features a logical, consistent chapter format that helps you find the guidance you need quickly. Presents abundant tables, differential diagnoses, lab values/radiologic studies, treatment/therapy recommendations, and guidance on when to refer to a specialist equipping you for every clinical challenge. Discusses controversies concerning the standard of care with the aid of thought-provoking clinical scenarios to help you to determine the best course of action in difficult situations. Provides highlighted boxes that emphasize relevant case studies, key points of each section, and other important information making you aware of considerations that impact today's practice. Uses a wealth of illustrations so you can see details more clearly.

"This first edition of the textbook “Adrenocortical Carcinoma: Basic Sciences and Clinical Concepts” provides a concise compilation of relevant data advancing our current understanding of this rare cancer. Chapters are dedicated to various aspects of both the basic biology and the clinical science relating to adrenocortical carcinoma (ACC). Expert clinicians introduce the reader to current state-of-the-art clinical care of patients with ACC. As a considerable body of knowledge on ACC has accumulated over the last decades, expert scientists have authored additional sections that serve as a reference source for the experienced researcher as well as an introduction for the trainee in the laboratory or clinic. Clinical topics span the epidemiology, diagnosis and therapy of ACC. Scientific topics areas span the pathology and pathophysiology of ACC with a special focus on experimental models of adrenocortical tumors and recent advances in the genetic aspects and signaling pathways in ACC. The content of this book was compiled and edited with the intent of facilitating the translation of knowledge into future diagnostic and therapeutic tools that will ultimately improve patient care."--Publisher's website.

This volume gives an overview on the currently debated ethical issues regarding advance directives from an international perspective. It focuses on a wider understanding of the known and widely accepted concept of patient self-determination for future situations. Although advance directives have been widely discussed since the 1980s, the ethical bases of advance directives still remain a matter of heated debates. The book aims to contribute to these controversial debates by integrating fundamental ethical issues on advance directives with practical matters of their implementation. Cultural, national and professional differences in how advance directives are understood by health care professions and by patients, as well as in laws and regulations, are pinpointed.

This text examines in detail mathematical and physical modeling, computational methods and systems for obtaining and analyzing biological structures, using pioneering research cases as examples. As such, it emphasizes programming and problem-solving skills. It provides information on structure bioinformatics at various levels, with individual chapters covering introductory to advanced aspects, from fundamental methods and guidelines on acquiring and analyzing genomics and proteomics sequences, the structures of protein, DNA and RNA, to the basics of physical simulations and methods for conformation searches. This book will be of immense value to researchers and students in the fields of bioinformatics, computational biology and chemistry. Dr. Dongqing Wei is a Professor at the Department of Bioinformatics and Biostatistics, College of Life Science and Biotechnology, Shanghai Jiaotong University, Shanghai, China. His research interest is in the general area of structural bioinformatics.

"The probability for exposure to damaging radiation, toxic chemicals in the environment and adverse biological agents has increased exponentially today. The more frequent and faster travel that we experience today also escalates the risk of contraction and transmission of potentially deadly infections. This has created a very real and escalating risk for injuries and deaths. This is accentuated in the military and medical staff that is more frequently exposed to radiological, chemical, and biological agents in their normal working environment. Understanding the mechanisms whereby these toxic agents inflict damage to our bodies is essential to prepare us for these challenges. Much of the damage is inflicted through the generation of free radicals and non-radical oxidants which then act through oxidative mechanisms to injury the body. This volume will discuss the damage caused by these radiological, chemical, and biological environmental stressors, the mechanisms through which the damage can occur and the novel strategies that can be used to reduce the injury inflicted by these toxic compounds. Using basic and clinical research approaches, the contents of this book discuss new ideas for the development of bioactive products and environmental approaches to lessen or negate the biological damage inflicted by these noxious compounds."--Publisher's website.

"Advances in Cardiac Imaging presents the latest information on heart disease and heart failure, major causes of death among western populations. In addition, the text explores the financial burden to public healthcare trusts and the vast amount of research and funding being channeled into programs not only to prevent such diseases, but also to diagnose them in early stages. This book provides readers with a thorough overview of many advances in cardiac imaging. Chapters include technological developments in cardiac imaging and imaging applications in a clinical setting with regard to detecting various types of heart disease"--Provided by publisher.

In this book, leading international specialists in the field join forces to discuss topics, issues, and approaches that are of key importance in the optimal treatment of lumbar degenerative disk disease. The coverage is wide ranging, from current understanding of physiopathology and genetics and modern imaging techniques through to the diverse minimally invasive, non-fusion, and fusion surgical techniques. Detailed attention is drawn to the most important aspects to be considered when approaching the patient and making treatment decisions. The role of conservative management is appraised, and surgical techniques and their indications are carefully described. Emphasis is placed on the importance of sagittal balance for treatment success. Among the various other subjects covered are psychosocial issues, legal aspects, outcome evaluation, and the relative merits of evidence-based medicine and individual experience. In the concluding section, some of the top specialists from across the world reflect on the lessons that they have learned during lifetimes in spinal surgery. Advanced Concepts in Lumbar Degenerative Disk Disease is intended as the definitive book on this important subject. It will be an instructive and fascinating source of information for all spine surgeons and other spine care providers.

In this book, international experts present up-to-date techniques of otoplasty in which they have extensive personal experience. Both new and modified procedures are described with the aid of a wealth of high-quality illustrations. In addition to these detailed descriptions, ear embryology and anatomy, psychological issues, postoperative care, possible risks and complications, and outcomes are extensively covered in order to provide the reader with a state of the art account of all aspects of cosmetic otoplasty.

"A reflection of the intense study of the effects of electromagnetic fields on living tissues that has taken place during the last several decades, this book discusses the theoretical and experimental evidence and considerations the effects of strong electromagnetic fields and/or electric pulses and their importance in medicine and biology. The authors present the basic techniques applied in electroporation and the advanced methods for creation of nanopores, highlighting their basic science and clinical applications. Topics include nano electroporation, classic electroporation, experimental evidence for electroporation of living cells, and electroporation for cancer and wound healing"--Provided by publisher.

"Advanced Healthcare Nanomaterials summarises the current status of knowledge in the fields of advanced materials for functional therapeutics, point-of-care diagnostics, translational materials, up and coming bio-engineering devices"-- Provided by publisher.

Since the publication of the first edition of Urethral Reconstructive Surgery, important refinements have been added to the urologic surgical armamentarium. Extensively revised and updated, Advanced Male Urethral and Genital Reconstructive Surgery, Second Edition guides urologists in a practical manner on how to evaluate and manage complex urethral and male genital reconstructive challenges. Chapters have been added on wound healing, synchronous urethral strictures, non-transecting anastomotic urethroplasty (including muscle and vessel sparing), overlapping buccal grafts, male urethral slings, genital skin grafting, Peyronies surgery, priapism, pediatric strictures, and prosthetics. Such chapters greatly strengthen the overall appeal of the book. The volume closes with a new comprehensive appendix of preferred instruments. With broad contributions by international authorities in reconstructiveurologic surgery, Advanced Male Urethral and Genital Reconstructive Surgery, Second Edition is a valuable resource for all urologists, from residents to reconstructive surgeons.

This text presents state-of-the-art techniques for surgery of the craniovertebral junction and cervical spine. It provides concise explanations of the underlying principles of each technique and insights into the unique issues in pediatric surgery.

This unique reference fulfills the unmet need of a textbook that addresses the scope of practice for surgeons practicing in rural regions. The text provides up-to-date content covering a wide breadth of topics relevant to surgical care in rural areas, with focus on the surgical diseases that are often treated by surgical subspecialists in the urban setting. Written by experts in each subspecialty, the text focuses on procedural aspects of surgical patient care. The first section discusses practice issues unique to rural surgery and provides an overview of applying principles of quality improvement to surgical practice. Subsequent chapters cover specific surgical procedures. Each chapter includes a brief discussion of indications and contraindications for surgery. The surgical technique is described with attention to important anatomic details. Key portions of the procedure are highlighted including potential complications and how to avoid them. Procedure specific perioperative care is also discussed. Supported with ample illustrations and images, Advanced Surgical Techniques for Rural Surgeons is a valuable resource for surgeons currently in practice or preparing to practice in a rural area, as well as surgical technicians, surgical nurse practitioners, and physician's assistants.

As a result of recent advances in surgical techniques and implant technology it is now possible to perform limb reconstruction in patients with a range of congenital, posttraumatic, and postinfection pathologies. This book is a clear, practical guide to the state-of-the-art surgical procedures employed in limb reconstruction for diverse conditions. It includes precise descriptions of the techniques themselves, accompanied by numerous helpful drawings and photographs. Pearls and pitfalls are highlighted, and thorough advice is also provided on indications, preoperative planning, and postoperative follow-up. The editors have carefully selected the contributors based on their expertise, and many of the authors were themselves responsible for developing the techniques that they describe.

This book bridges gap between the practicing community of surgeons and the surgical innovators, and it provides a foundation for all classic and new techniques in minimally invasive colorectal surgery. It provides tips and tricks that allow the user to move up the learning curve, manage difficult scenarios, overcome challenges, increase the utilization of minimal invasive techniques and decrease the conversion to open surgery. By enhancing the surgical tool box, the surgeon will be able to progress from the novice to the master. Rather than describing operative procedures, which may be very biased by an individual author, the guide provides alternative building blocks of various difficulty for different procedures, thereby allowing the surgeon to tailored surgery to patient and surgeon's own comfort level and experience. Advanced Techniques in Minimally Invasive and Robotic Colorectal Surgery is an inspirational guide for the innovator of the future. This text allows surgeons of all levels to better adapt to inevitable changes in future techniques. Advanced Techniques in Minimally Invasive and Robotic Colorectal Surgery is of great value to general surgeons, colon and rectal surgeons, minimally invasive surgeons as well as residents and fellows.

Intended as a companion to the Fundamentals of Forensic DNA Typing volume published in 2009, Advanced Topics in Forensic DNA Typing: Methodology contains 18 chapters with 4 appendices providing up-to-date coverage of essential topics in this important field and citation to more than 2800 articles and internet resources. The book builds upon the previous two editions of John Butler's internationally acclaimed Forensic DNA Typing textbook with forensic DNA analysts as its primary audience. This book provides the most detailed information written to-date on DNA databases, low-level DNA, validation, and numerous other topics including a new chapter on legal aspects of DNA testing to prepare scientists for expert witness testimony. Over half of the content is new compared to previous editions. A forthcoming companion volume will cover interpretation issues. Contains the latest information - hot-topics and new technologies Well edited, attractively laid out, and makes productive use of its four-color format Author John Butler is ranked as the number one "high-impact author in legal medicine and forensic science, 2001 to 2011" by ScienceWatch.com.

"This volume explores the use of mass spectrometry for biomedical applications. Chapters focus on specific therapeutic areas such as oncology, infectious disease and psychiatry. Additional chapters focus on methodology as well as new technologies and instrumentation. This volume provides readers with a comprehensive and informative manual that will allow them to appreciate mass spectrometry and proteomic research but also to initiate and improve their own work. Thus the book acts as a technical guide but also a conceptual guide to the newest information in this exciting field. Mass spectrometry is the central tool used in proteomic research today and is rapidly becoming indispensable to the biomedical scientist. With the completion of the human genome project and the genomic revolution, the proteomic revolution has followed closely behind. Understanding the human proteome has become critical to basic and clinical biomedical research and holds the promise of providing comprehensive understanding of human physiological processes. In addition, proteomics and mass spectrometry are bringing unprecedented biomarker discovery and are helping to personalize medicine"--Publisher's description.

Magnetic resonance imaging (MRI) is a versatile imaging tool that can be used to detect changes in brain hemodynamics that accompany neuronal activity. This ability to observe both anatomy and the structures that participate in specific functions is often referred to as functional magnetic resonance imaging (fMRI). Echo planar imaging (EPI) is the most widely used data acquisition method for fMRI. Functional images are often distorted because EPI is highly sensitive to field inhomogeneities, eddy currents, and gradient delays. These distortions often lead to image misregistration, and this is an impediment to correctly interpreting functional studies, and to neurosurgical planning. Many methods have been developed to address this. However, none yields anatomical and functional images that may be directly overlaid onto each other with no post-processing. This dissertation demonstrates that automatic, inherent self co-registration is achieved when optimized flyback EPI with echo time shifting (ETS) is used for both functional and anatomical images. fMRI experiments validate the proposed method, and the result is high-quality functional and high-resolution anatomical images that are inherently self co-registered. EPI acquisitions are also prone to timing and phase errors that give rise to image ghosting. ETS is an effective ghost correction method in EPI. Although ETS corrects for ghosting in a robust, non-iterative, and automatic manner, it does so at the expense of increasing total scan time. This dissertation proposes a simple, yet effective scheme to increase the efficiency of ETS by acquiring partial echoes during the idle wait times present in ETS. Using the proposed technique, higher resolution images are acquired when total scan time is fixed. Alternately, shorter scan times are possible when the in-plane resolution is fixed. Equations that predict the expected improvement in resolution are derived and shown to be accurate through simulations and experiments. In vivo images obtained using conventional ETS and the proposed method show that the time savings obtained with the proposed method do not result in any visible degradation in image quality. Signal changes caused by cardiac pulsation and respiratory fluctuation are also a major confound in fMRI. These time-locked signal changes, also referred to as "physiological noise, " decrease the sensitivity of fMRI to neuronally-induced signal fluctuations. To date, no method exists that compensates for these detrimental effects in 3D fMRI acquisitions. This dissertation presents a novel algorithm that compensates for physiological noise in 3D echo-planar fMRI. The proposed method utilizes composite property mapping and efficient root-solving to estimate physiologically-induced signal fluctuations in 3D k-space data. These signal fluctuations are subsequently regressed from k-space data. Results show that the estimated signal fluctuations have significant power in the cardiac and respiratory frequency bands. Further, resting-state fMRI experiments show an increase in the number of activated voxels when the proposed compensation algorithm is employed. This is accompanied by an increase in the average z-score of activated voxels, and a more Gaussian distributed voxel time-course. In conclusion, this dissertation describes advances in data acquisition and post- processing in 3D fMRI that are easy to implement. Further, promising experimental results suggest the efficacy of all the proposed methods.

The subject matter of the ADPD conferences is unique in that it deals not only with issues related individually to Alzheimer's disease and Parkinson's disease, but also with the integration of these and other related diseases. The most up-to-date techniques and research findings are illustrated in this volume.

Despite the advances in conventional, and novel agent and high dose chemotherapy, multiple myeloma remains incurable. In order to overcome resistance to current therapies and improve patient outcome, novel biologically-based treatment approaches are being developed. Current translational research in multiple myeloma focusing on the development of molecularly-based novel targeted single-agent and combination therapies has great promise to achieve high frequency and durable responses in the majority of patients. This volume will focus on biology of multiple myeloma, especially on oncogenomic changes, cell signaling pathways and intermediate molecules that are being investigated for development of novel therapies. The book will present newer developments, providing an emphasis on basic science, as well as its significant clinical impact.

Despite the advances in conventional, and novel agent and high dose chemotherapy, multiple myeloma remains incurable. In order to overcome resistance to current therapies and improve patient outcome, novel biologically-based treatment approaches are being developed. Current translational research in multiple myeloma focusing on the development of molecularly-based novel targeted single-agent and combination therapies has great promise to achieve high frequency and durable responses in the majority of patients. This volume will focus on biology of multiple myeloma, especially on oncogenomic changes, cell signaling pathways and intermediate molecules that are being investigated for development of novel therapies. The book will present newer developments, providing an emphasis on basic science, as well as its significant clinical impact.

Breast magnetic resonance imaging (MRI) is becoming an increasingly valuable technology for breast cancer detection, especially for women at high risk for the disease. Stanford Hospital alone performed approximately 1,000 breast MRIs last year. This demand and need to increase specificity of breast MRI motivates improving current breast MR protocols, as well as exploring new applications of MR technology to breast imaging. Most clinical breast MR exams are performed at a 1.5T field strength. 3T scanners, however, are becoming more prevalent in the clinical setting and thus the breast MR protocol needs to be tuned accordingly. The first project includes measurements of T1 and T2 of breast fat and glandular tissue at 1.5T and 3T and the corresponding recommendation for altering the TR and TE for 3T breast imaging. The beating heart posterior to the breast often produces artifacts in breast MR images. The second project is a cylindrical saturation method that reduces unwanted signal from the heart while avoiding signal loss from the breast tissue of interest. Detecting tumor oxygenation non-invasively may give insight on tumor differentiation, predict susceptibility to antiangiogenic therapeutics, and monitor chemotherapeutics. The third project introduces the application of BOLD contrast imaging, a technique usually applied in functional brain MR imaging for characterizing tumor oxygenation in the breast.

"At present there are a growing number of biomolecules under investigation to understand their potential role as cancer biomarker for diagnostic, prognostic and therapeutic purposes. Intriguingly, the state of art on cancer biomarkers research shows interesting and promising results together to clamorous failures. Also from a clinical point of view, there are contradictory results on routine clinical use of the present cancer biomarkers. Some patients may be simply monitored in their course by a periodic blood sample, but sometimes this monitoring shows dramatic limits. A lot of patients show serious and extensive relapses without significant change in serum concentrations of biomarkers tested. Often the physician who should utilize these biomarker does not entirely know their limits and the total potential applications as well and sometimes this knowledge is influenced by economical and marketing strategies. This limited and "polluted" knowledge may have dramatic consequences for patient. The aim of this book is to diffuse all aspects of cancer biomarkers, from their biochemical peculiarities to all clinical implications by passing through their physiology and pathophysiology. This critical approach towards old and new cancer biomarkers should foster a deepened and useful understanding of the diagnostic and prognostic index of these fundamental parameters of laboratory medicine and in the same time facilitating the research of new and more sensitive-specific signals of the cancer cell proliferation"--Back cover.

This volume presents the MD Anderson experience in providing care and services to the rapidly growing population of cancer survivors, which is currently estimated to be 12 million in the United States and more than 25 million worldwide. As cancer survival rates have increased, it has slowly become clear that the challenges faced by people with cancer do not end with treatment but simply change. This book aims to assist community oncologists, physicians, and their staff, who care for the vast majority of cancer survivors, by disseminating models of surveillance for disease recurrence, screening for second primary cancers, education regarding potential late effects of treatment, and psychosocial counseling. These models have proven valuable to cancer survivors who receive care at MD Anderson.

Chronic lymphocytic leukemia (CLL) is the most common leukemia in the Western world. CLL has a highly varied clinical course. While advances in CLL therapy are noted, many patients still succumb to this illness. Like most progress in medicine, solid advances in the diagnosis, prognosis and treatment of CLL are rooted in an in-depth understanding of the basic and translational biology of CLL. In this book, CLL experts have contributed state-of-the-art summaries of various important aspects of CLL biology and have discussed the translational implication of such findings. This book, which is directed at physicians and researchers alike, aims to educate broadly and deeply. Intentionally, the many aspects and nuances of CLL clinical care that can only really be appreciated through direct patient care are not covered here, but instead, the book presents basic aspects of CLL that underlie many of the contemporary decisions that are made in CLL research and clinical settings. We hope that this book will critically inform the community and stimulate interest in CLL, which will ultimately translate into better CLL research, prognostication and therapy, with the end goal of providing a better outlook for patients afflicted with this common leukemia.

Prevalence of olfactory impairment in granulomatosis with polyangiitis -- Biochemistry of oxidative stress -- Usage of over-the-counter and herbal products in common cold in Poland: findings from consumer survey -- RARβ promoter methylation as an epigenetic mechanism of gene silencing in non-small cell lung cancer -- Cardiovascular risk factors in obese children and adolescents -- Nutrition and immune system in children with simple obesity -- The influence of shockwave therapy on orthodontic tooth movement induced in the rat -- Thyroid hormone levels and TSH activity in patients with obstructive sleep apnea syndrome -- Age and gender-related changes in biogenic amine metabolites in cerebrospinal fluid in children -- The influence of primary cytomegalovirus or Epstein-Barr virus infection on the course of idiopathic thrombocytopenic purpura -- Index.

"Preface This book brings together a wide-ranging set of contributed articles that address emerging practices and future trends in cognitive engineering and neuroergonomics. Both aim to harmoniously integrate human operator and computational system, the former through a tighter cognitive fit and the latter a more effective neural fit with the system. The chapters in this book uncover novel discoveries and communicate new understanding and the most recent advances in the areas of workload and stress, activity theory, human error and risk, and neuroergonomic measures, as well as associated applications.-- Provided by publisher.

Within our knowledge, the series of the International Conference on Cognitive Neurodynamics (ICCN) is the only conference series dedicating to cognitive neurodynamics. This volume is the proceedings of the 2nd International Conference on Cognitive Neurodynamics held in 2009, which reviews the progress in this field since the 1st ICCN -2007. The topics include: Neural coding and realistic neural network dynamics, Neural population dynamics, Firing Oscillations and Patterns in Neuronal Networks, Brain imaging, EEG, MEG, Sensory and Motor Dynamics, Global cognitive function, Multi-scalar Neurodyn

This book contains the Proceedings of the 3rd International Conference on Cognitive Neurodynamics held in Japan, June 9-13, 2011. It reviews the progress in this field since the first ICCN in 2007. The participants were treated to an exciting and stimulating conference that left everyone with an enthusiastic vision for the future. The discussed topics in this book include: Neural coding and realistic neural network dynamics, Neural population dynamics, Firing Oscillations and Patterns in Neuronal Networks, Brain imaging, EEG, MEG, Sensory and Motor Dynamics, Global cognitive function, Multi-scalar Neurodynamics - from Physiology to Systems Theory, Neural computing, Emerging Technologies for Brain Computer Interfaces, Neural dynamics of brain disorders.

Overview, The IOM Report, and Integrated Marketing Communications -- Introduction: Childhood Obesity: Media, Advertising, Community, and Advocacy -- Progress on Public Policy: The Aftermath of the 2005 Institute of Medicine Report on Food Marketing and the Diets of Children and Youth -- Integrated Marketing Communications and Power Imbalance: The Strategic Nature of Marketing to Children and Adolescents by Food and Beverage Companies -- Legal, Ethical, and Policy Implications of Advertising -- The Role of Ethics in Food and Beverage Marketing to Children -- The New First Amendment and Its Implications for Combating Obesity Through Regulation of Advertising -- Self-regulation as a Tool for Promoting Healthier Children's Diets: Can CARU and the CFBAI Do More? -- Monitoring Food Company Marketing to Children to Spotlight Best and Worst Practices -- Measuring the Impact of Advertising Effects -- Children's Exposure to Food and Beverage Advertising on Television: Tracking Calories and Nutritional Content by Company Membership in Self-regulation -- The Role of Advertising on Attitudes and Consumption of Food and Beverage Products -- The Digital Food Marketing Landscape: Challenges for Researchers -- A Multi-Method Study to Understand How Youth Perceive and Evaluate Food and Beverage Advertisements -- A Global Perspective of Food Marketing and the Role of Place -- Adolescents' Response to Food Marketing in Delhi, India -- The Role of Schools in Food and Beverage Marketing: Significance, Challenges, Next Steps -- Outdoor Food and Beverage Advertising: A Saturated Environment -- Exploring Marketing Targeted at Youth in Food Stores -- Racial/Ethnic Minorities and Community Empowerment -- Understanding Community Perspectives: A Step Towards Achieving Food Marketing Equity -- Latino Youth and Obesity: Communication/Media Influence on Marketing -- Targeted Marketing of Junk Food to Ethnic Minority Youth: Fighting Back with Legal Advocacy and Community Engagement -- Communicating About Physical Activity -- Physical Activity, Media, and Marketing: Advances in Communications and Media Marketing -- Communities Leveraging the Assets of a National Social Marketing Campaign: Experiences with VERB[TM]. It's What You Do! -- Development and Release of the 2008 Physical Activity Guidelines for Americans: Children and Adolescents -- Thinking Outside the Box: Finding Solutions to Reverse Childhood Obesity -- Voluntary Health Organizations and Nonprofit Advocacy Organizations Play Critical Roles in Making Community Norms More Supportive of Healthier Eating and Increased Physical Activity -- Childhood Obesity and Exergames: Assessments and Experiences from Singapore -- Leveraging Industry Efforts to Fight Childhood Obesity: A Multi-Sectored Approach to Communications.

This volume is an up-to-date resource on the international state-of-the-art in the diagnosis and management of ovarian cancer. While this devastating disease has been considered mainly a disease of the Western hemisphere, the book moves beyond our conventional understanding and embraces knowledge from around the world. It focuses on recent advances in diagnosis, including genetic screening; improvements and expanded choices in management, such as gene therapy and the optimization of chemotherapeutic agents; and the latest laparoscopic and robotic surgical techniques. Further chapters address histopathologic features of this disease, and related psychosocial and quality of-life-issues. The book is aimed at the wide range of practitioners who care for patients with ovarian cancer and researchers who study the disease: general surgeons, surgical oncologists, gynecological oncologists, medical oncologists, pediatric oncologists, gynecological pathologists, gynecologists, gynecological cancer epidemiologists, gynecological onco-psychologist, genetic counselors, geneticists, and cancer research scientists.

In recent years there has been significant attention paid on the endophytic research by various groups working within this domain. Mutualistic endophytic microbes with an emphasis on the relatively understudied fungal endophytes are the focus of this special book. Plants are associated with micro-organisms: endophytic bacteria and fungi, which live inter- and intra-cellularly without inducing pathogenic symptoms, but have active biochemical and genetic interactions with their host. Endophytes play vital roles as plant growth promoters, biocontrol agents, biosurfactant producers, enzymes and secondary metabolite producers, as well as providing a new hidden repertoire of bioactive natural products with uses in pharmaceutical, agrochemical and other biotechnological applications. The increasing interest in endophytic research generates significant progress in our understanding of the host-endophyte relationship at molecular and genetic level. The bio-prospection of microbial endophytes has led to exciting possibilities for their biotechnological application as biocontrol agent, bioactive metabolites, and other useful traits. Apart from these virtues, the microbial endophytes may be adapted to the complex metabolism of many desired molecules that can be of significant industrial applications. These microbes can be a useful alternative for sustainable solutions for ecological control of pests and diseases, and can reduce the burden of excess of chemical fertilizers for this purpose. This book is an attempt to review the recent development in the understanding of microbial endophytes and their potential biotechnological applications. This is a collection of literature authored by noted researchers having signatory status in endophytic research and summarizes the development achieved so far, and future prospects for further research in this fascinating area of research.

"To celebrate the Center for Perinatal Biology's 40th Anniversary, an illustrious group gathered at Loma Linda University in February 2013. That gathering of experts and this volume of the proceedings are a tribute to the founder of the Center, Lawrence D. Longo, M.D. These chapters present contributions from individuals who in some way or another were influenced by Dr. Longo. Covering a wide range of topics, and illustrating the diversity of thinking and scientific interests, these proceedings address basic science through to clinical problems in the developmental programming of health and disease"--Publisher's description.

This concise, easy-to-read book summarizes the current clinical evidence and basic science relating to aging and the skin, assisting the clinician in addressing skin problems in older dermatologic patients. Each chapter focuses on a particular area in which new knowledge has rapidly emerged over the past 5 years, ensuring that the book is completely up-to-date. Recent insights into aging skin from basic and translational science are first discussed, covering the underlying genetics and the potential role of topical agents and procedures in reversing the aging process. Evidence-based prescribing in older patients is then explained, and the evidence relating to treatments for psoriasis, reviewed. Further chapters in Geriatric Dermatology address non-surgical treatment options for basal cell carcinoma, the increase in and management of sexually transmitted diseases in older dermatology patients, and cutaneous signs of elder mistreatment. Case vignettes and informative illustrations assist the reader in quickly grasping the connection between an age-related process and its clinical impact. Geriatric Dermatology is written for dermatologists, research scientists with translational interest, geriatricians, and gerontologists.

Over the past decade, enormous progress has been made in understanding the late events in the HIV replication cycle. This has been made possible by major advances in cell biology, virology, and structural biology. The field continues to move forward rapidly, with important new discoveries being reported on a regular basis. The impact of this progress across a broad spectrum of biomedical research has been substantial. The increase in basic knowledge in the areas of HIV assembly, release, and maturation has been accompanied by new possibilities for therapeutic intervention.The work includes topics relating to basic molecular biology, cell biology, and structural biology of HIV assembly, coupled with more applied ideas of how this basic information can inform the field of antiretroviral research. The book covers all major topics pertaining to the late stages of HIV replication, with leaders in each area recruited to contribute chapters in their areas of expertise . The topics will be sufficiently focused to allow authors the opportunity to cover the latest developments in detail.

"This book discusses how human factors and ergonomics principles can be applied to improve quality, safety, efficiency, and effectiveness in patient care. The topics will include the design of work environments to improve satisfaction and well-being of patients, healthcare providers, and professionals. The utility of this area of research is to aid the design of systems and devices for effective and safe healthcare delivery"-- Provided by publisher.

"Based on recent research, this book discusses how to improve quality, safety, efficiency, and effectiveness in patient care through the application of human factors and ergonomics principles. It provides guidance for those involved with the design and application of systems and devices for effective and safe healthcare delivery from both a patient and staff perspective. Its huge range of chapters covers everything from the proper design of bed rails to the most efficient design of operating rooms, from the development of quality products to the rating of staff patient interaction. It considers ways to prevent elderly patient falls and ways to make best use of electronic health records. It covers staff interactions with patients as well as staff interaction with computers and medical devices. It also provides way to improve organizational aspects in a healthcare setting, and approaches to modeling and analysis specifically targeting those work aspects unique to healthcare. Explicitly, the book contains the following subject areas: I. Healthcare and Service Delivery. II. Patient Safety. III. Modeling and Analytical Approaches. IV. Human-System Interface: Computers & Medical Devices. V. Organizational Aspects"--Provided by publisher.

This book provides an overview of the current state-of-art in combining advances in biomedical imaging with intraoperative navigation and preoperative planning for urologic surgery. These advances hold great promise in improving diagnostic and therapeutic urologic interventions to improve patient outcomes. Leading experts in this exciting emerging field covers early clinical and pre-clinical applications of optical, ultrasound, cross-sectional, and computer-assisted imaging in urologic surgery. Advances in Image-Guided Urologic Surgery provides a unique and valuable resource for audience with clinical and research interest in minimally invasive surgery, endourology, urologic oncology, imaging, and biomedical engineering.

With an increase in the use of laparoscopic techniques for the treatment of abdominal wall hernias, this comprehensive book provides a detailed description of the most up-to-date techniques used in the laparoscopic repair of inguinal and ventral incisional hernias. Advances in Laparoscopy of the Abdominal Wall Hernia takes the reader step-by-step through two laparoscopic techniques used in inguinal hernia correction: Extraperitoneal (TEP) and Transabdominal (TAPP), and guides the reader through the fundamentals of ventral hernia repair. The authors aim to show methods of dealing with rarer hernias and those of atypical location. This book will also inform the reader of the various kinds of meshes used and provides knowledge on how to fix them, as well as the advantages, disadvantages and indications of this type of prosthesis. Written by experts in the field, Advances in Laparoscopy of the Abdominal Wall Hernia is a valuable reference tool to surgeons and medical practitioners working in this field.

This book presents up-to-date information on the diagnosis and management of the spectrum of medical and surgical corneal diseases, with a special focus on new technology. The latest tools for diagnosing ocular surface disease, infectious keratitis, and ocular allergies are discussed, along with novel treatment options for these entities. The impact of progress in imaging and contact lens technology on the management of corneal conditions is fully described, and the efficacy of corneal collagen crosslinking for keratoconus and corneal ectasia is evaluated. Detailed attention is devoted to the latest surgical techniques, including lamellar keratoplasty, endothelial keratoplasty, keratoprosthesis, and laser-assisted penetrating keratoplasty. In addition, the role of the eye bank in facilitating corneal procedures is explained. Advances in Medical and Surgical Cornea is written by leading authorities who share a passion for effective, cutting-edge care. It will be invaluable for both experienced ophthalmologists and trainees.

Beyond Stanford

Continuously expanding, all databases in the repository
contain the latest editions of selected medical titles.

MicroMedex: Premier pharmaceutical
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tools. Of particular value is DRUGDEX Evaluations, one of the most
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are updated daily as new evidence becomes available.Scopus is the largest abstract and citation
database of peer-reviewed literature: scientific journals, books and
conference proceedings.A drug
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(AHFS), drug formulary for Lucile Packard Children's Hospital (LPCH)
and Stanford Hospital & Clinics (SHC), Lexi-Drugs (adverse
reactions, dosage and administration, mechanism of action, storage,
use, and administration information), Lexi-Calc, Lexi-ID, Lexi-I.V.
Compatibility (King Guide), Lexi-Interact, and Lexi-PALS.Cumulative Index to Nursing and Allied
Health Literature (CINAHL) contains coverage of nursing and allied
health literature.A knowledge
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regularly, provides the latest practice guidelines in 59 medical
specialtiesProvides critical
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Multidisciplinary
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proceedings coverage for over 120,000 conferences.

Includes cited reference searching, citation maps, and an
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makes a determination whether the intervention is efficacious or
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Cochrane reviews are created through a strict process of
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Provides systematic coverage of the
psychological literature from the 1800s to the present through
articles, book chapters and dissertations.BMJ
Clinical Evidence. A clinical information tool built around
systematic reviews summarizing the current state of knowledge about
prevention and treatment of clinical conditions.PIER (Physicians' Information and Education
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point-of-care delivery of up-to-date, evidence-based guidance for
primary care physicians.Cochrane
Central Register of Controlled Trials (CENTRAL) provides access to
300,000 controlled trials that have been identified the Cochrane
Collaboration.Provides drug
information targeted for patients.A
continually updating drug monograph.The National Guideline
Clearinghouse (NGC): A comprehensive database of evidence-based
clinical practice guidelines and related documents.MedlinePlus: A repository of health
information from the National Library of Medicine. Links are from
trusted sites. No advertising, no endorsement of commercial companies
or productsLPCH
CareNotes via MicroMedex: Patient education handouts customized by
LPCH clinical staffMicromedex
Lab Advisor: Evidence based laboratory test informationA drug database organized by generic
name, trade name and drug class.LPCH /
Stanford Hospital Formulary.A
goldmine of trusted consumer health information from the world's
largest medical library.A trusted
source of expert advice for and about kids, providing the information
necessary to help patients and parents understand their unique needs.Provides patient handouts from the
American Academy of Family Physician.Access
to the Stanford Health Library for patients.Lane
provides access to over 5,000 eBooks many of which provide helpful
background material that will prepare you to better tackle primary
literature.

Largest,
broadest eBook package; covers all sciences, as well as technology
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In addition to covering Wiley and Springer, MyiLibrary is also
the only provider for Oxford and Cambridge University Press titles.
No seat restrictions.

A
collection of biomedical books that can be searched directly by
concept, and linked to terms in PubMed abstracts.

Over 10,000 notes outline the status of specific infections
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Large number of high quality software
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science and biomedical engineering.Over
4,000 full-text e-books covering scientific and technical information
from CRC Press and others. Many handbooks and single volume reference
sources.Includes
peer-reviewed life science and biomedical research protocols compiled
from Methods in Molecular Biology, Methods in Molecular Medicine,
Methods in Biotechnology, Methods in Pharmacology and Toxicology,
Neuromethods, the Biomethods Handbook, the Proteomics Handbook, and
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Provides online, full-text
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Collection of
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