Synaffix BV

Formed in 2010, Synaffix is a Netherlands-based biotechnology company exclusively focused on continued advancement of a best-in-class antibody-drug conjugate (ADC) technology platform. As a leading innovator in the field of ADCs offering absolute versatility and state-of-the-art solutions, the vision of Synaffix is to become the preferred partner in the development of these complex biological therapeutics and realize its ambition - connect to cure.

AMSTERDAM, NETHERLANDS – December 6, 2017 – Synaffix BV, a biotechnology company that has developed a proprietary site-specific conjugation platform technology to enable differentiated antibody-drug conjugates (ADCs), today announced the launch of a new platform of highly potent cytotoxic ADC payloads that will be integrated into its existing ADC platform. With this expansion, Synaffix becomes a one-stop provider for technologies required to rapidly translate antibodies into proprietary ADC products.

Synaffix BV, a biotechnology company that has developed a proprietary site-specific platform technology to enable differentiated antibody-drug conjugates (ADCs), today announced the granting of a key patent that encompasses the entire GlycoConnect™ process.

Synaffix BV announced today that ADC
Therapeutics has triggered a second target-specific license under their Commercial License
Agreement dated October 2016, to develop an antibody-drug conjugate (ADC) using Synaffix’s
proprietary site-specific antibody-drug conjugation technology. As part of the original
agreement, ADC Therapeutics retains an option to take a limited number of additional singletarget
licenses for their potential future programs.

World ADC is pleased to announce the finalists in the 4th Annual World ADC Awards. The World ADC Awards showcase the innovation, leadership and devotion shown by the best companies, teams and individuals in the industry. Across 9 categories the Awards will recognise the extraordinary endeavours, teamwork and commercial acumen that has propelled the field to the forefront of cancer research today.

exclusively focused on the development of industry-leading antibody-drug conjugate
(ADC) technology platforms, today announced that a key patent covering its HydraSpace™
spacer technology has been granted by the United States Patent and Trademark Office
(US 9,636,421 B2).

AMSTERDAM, NETHERLANDS – February 20, 2017 – Synaffix BV, a biotechnology company exclusively focused on the development of industry-leading antibody-drug conjugate (ADC) technology, today announced a new set of head-to-head data, that demonstrates the potential of its technology to significantly expand the therapeutic index vs cysteine-engineered ADCs.

AMSTERDAM, NETHERLANDS – December 8, 2016 – Synaffix BV, a biotechnology
company exclusively focused on the development of industry-leading antibody-drug
conjugate (ADC) technology platforms, today announced that a key patent that
encompasses the entire GlycoConnect™ process used to prepare glycan-conjugated ADCs
has been granted in the US (US 9,504,758 B2), further strengthening its IP portfolio.

AMSTERDAM, NETHERLANDS – October 20, 2016 – Synaffix BV announced today it has entered
into a Commercial License Agreement with ADC Therapeutics for its proprietary GlycoConnect™
and HydraSpace™ site-specific antibody-drug conjugate technologies.
Under the terms of the agreement, ADC Therapeutics has been granted a single-target license
for one of its preclinical programs and has also been granted an option to take a limited number
of additional single-target licenses for potential future programs.

AMSTERDAM, THE NETHERLANDS — Synaffix BV, a biotechnology company exclusively focused on the development of industry-leading antibody-drug conjugate (ADC) technology platforms, today announced the completion of a new set of preclinical studies that further supports the potential for its technology to enable safer and more effective targeted cancer therapeutics. The data obtained in these studies capture the outcomes from its latest R&D efforts demonstrating that Synaffix platform technologies, GlycoConnect™ and HydraSpace™, generate ADCs with significantly improved therapeutic index when compared directly to Kadcyla® and Adcetris®, the two FDA-approved ADCs for the treatment of Her2-positive breast cancer and multiple lymphoma indications, respectively.