The results show that NUCKS1 is a chromatin-associated protein with a role in the DNA damage response and in homologous recombination, a DNA repair pathway critical for tumor suppression.

NUCKS is a physiological regulator of energy homeostasis and glucose metabolism that works by regulating chromatin accessibility and RNA polymerase II recruitment to the promoters of IR and other insulin (show INS ELISA Kits) pathway modulators.

NUCKS1 overexpression may be associated with tumour progression and recurrence in cervical squamous cell carcinoma

NUCKS-1 overexpression is associated with obesity and with breast cancer.

We would like to emphasize that NUCKS abundance in malignant skin tumors is higher than that of the well-known proliferation marker Ki67 (show MKI67 ELISA Kits), thus allowing more precise assessment of tumor proliferation potential.

The expression of Nucks in both proliferating and quiescent cells and its correlation with Bax (show BAX ELISA Kits) levels and apoptosis strongly suggest that Nucks plays complex roles in cell homeostasis.

Through a combination of gene expression and copy number analysis, NUCKS1 was identified as a candidate gene involved in the distant metastasis of colorectal cancer.

NUCKS is a physiological regulator of energy homeostasis and glucose metabolism that works by regulating chromatin accessibility and RNA polymerase II recruitment to the promoters of IR and other insulin (show INS ELISA Kits) pathway modulators.

The expression of Nucks in both proliferating and quiescent cells and its correlation with Bax (show BAX ELISA Kits) levels and apoptosis strongly suggest that Nucks plays complex roles in cell homeostasis.

Antigen Summary

This gene encodes a nuclear protein that is highly conserved in vertebrates. The conserved regions of the protein contain several consensus phosphorylation sites for casein kinase II and cyclin-dependent kinases, two putative nuclear localization signals, and a basic DNA-binding domain. It is phosphorylated in vivo by Cdk1 during mitosis of the cell cycle.