Patients' mean (standard deviation [sd]; range) age was 29 (3; 22–37) years. Infertility was the most common reason (64%) for seeking treatment. The mean (sd) duration of CC treatment was 19 (14) months.

At the last evaluation, 70% of men were using 25 mg CC every other day, and the remainder were using 50 mg every other day.

All mean testosterone and gonadotropin measurements significantly increased during treatment.

Subjectively, there was an improvement in all questions (except loss of height) on the ADAM questionnaire. More than half the patients had an improvement in at least three symptoms.

There were no major side effects recorded and the presence of a varicocele did not have an impact on the response to CC.

CONCLUSION

Long-term follow-up of CC treatment for HG shows that it appears to be an effective and safe alternative to testosterone supplementation in men wishing to preserve their fertility.