Urotensin II (U-II) is a cyclic heptapeptide that functions both as a potent vasoconstrictor and a neurotransmitter/neuromodulator. U-II circulates in the plasma as a zymogen, and is activated by the urotensin converting enzyme. U-II is the endogenous ligand for the G-protein coupled receptor 14 (GPR14), recently renamed the UT receptor.

Catalog #

U2800-01G

Changes in the expression of U-II and its receptor have been associated with cardiovascular and renal diseases, including atherosclerosis, myocardial infarction, and diabetic nephropathy.

Applications

Suitable for use in ELISA and Immunoassays. Other applications not tested.

Recommended Dilution

Optimal dilutions to be determined by the researcher.

Hybridoma

Sp2/0 myeloma cells with spleen cells from Balb/c mice.

Storage and Stability

May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Clone Type

Monoclonal

Isotype

IgG1

Clone No

10F579

Host

Mouse

Source

Human

Concentration

~1mg/ml

Form

Supplied as a liquid in PBS, pH 7.4, 0.09% sodium azide.

Purity

Purified by Protein A affinity chromatography.

Immunogen

Human Urotensin II.

Specificity

Recognizes human Uroensin II.

Important Note

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.