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Investigators report a novel therapeutic strategy that preferentially targets tumor-initiating cells (TICs) in small cell lung cancer in which cisplatin is combined with CBL0137, an inhibitor of the histone chaperone facilitates chromatin transcription (FACT), which is highly expressed in TICs. [Cancer Res]
Abstract | Full Article

Researchers utilized a series of in vitro, in vivo and patient-derived organoid approaches to systematically investigate the chemoprotective role of OPCs in colorectal cancer. OPCs exerted anti-tumorigenic effects through inhibition of cellular proliferation, and induced apoptosis and cell cycle arrest. [Sci Rep]
Full Article

Researchers investigated the effect of hyperthermia, 6 MeV electron radiation and combination of these treatments on cancer cell line DU145 in both monolayer culture and spheroids enriched for prostate CSCs. [Radiat Environ Biophys]
Abstract

The authors describe metabolic futures of CSCs with a special focus on lipid metabolism, which until now represents an underappreciated force in maintaining CSCs and an attractive therapeutic target. [Oncogene]
Abstract

Visit our
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the cancer stem cell research field.

The University of Pittsburgh (Pitt) and University of Pittsburgh Medical Center (UPMC) announced plans to establish the new UPMC Immune Transplant and Therapy Center, with much of its activity planned within an eight-story innovation hub—all part of a concerted effort to harness the power of the human immune system to treat and cure a wide range of diseases. [The University of Pittsburgh Medical Center]
Press Release

Cancer Research UK announced that £45 million will be invested into its network of clinical trials units across the UK, one of the charity’s largest investments in clinical research to date. [Cancer Research UK]
Press Release

Tens of thousands of UK researchers are expected to walk out of their universities in a nationwide strike over pensions that is likely to disrupt scientific experiments, conferences and lectures. [Nature News]
Editorial

Fresh off a plane from the NATO meeting in Munich, where he’d conferred with world leaders on global defense, former U.S. Vice President Joe Biden issued a forceful call here last night to build on the “Cancer Moonshot” he started while in the White House and transform the way the world fights cancer. [ScienceInsider]
Editorial

A job that’s been held by some of the nation’s top scientists is now occupied by a 31-year-old politics major from Princeton University. And it’s unlikely to change soon, observers say, leaving President Trump without a science advisor as the administration wrestles with a severe outbreak of the flu, lead-poisoned drinking water and record-breaking disasters that many scientists say are sharpened by rising temperatures. [Scientific American]
Editorial