Chemistry Terms

Abstract

The synthesis of glycidic esters from the condensation between aldehydes or ketones and esters of α-halo-carboxylic acids is known as Darzens condensation. This type of condensation has also been extended to α-halogenated nitriles, sulfoxides, sulfones, sulfoximines, carboxylic amides, etc. The reaction between carbonyl compounds and α-halogenated ketimine is also referred to as the aza-Darzens reaction. This reaction has been modified to occur in the solid-liquid two-phase system using a solid base and catalyst at temperatures higher than 100°C.