Video from the scene of the plane crash shows chaos on the 405 Freeway immediately after impact.

The captain said two people aboard the plane, a man and woman in their 50s and early 60s, suffered traumatic injuries and were transported by helicopter to a hospital. The Orange County Global Medical Center confirmed it was expecting to receive multiple trauma patients. The plane is designed to hold six people, but only two were aboard.

The plane had departed from John Wayne Airport in the morning, but shortly after takeoff, the pilot declared an emergency and was trying to return to the airport when the crash occurred, according to the FAA.

A driver described the moment a small plane clipped his car before the aircraft crashed on the 405 Freeway near John Wayne Airport on Friday.

ABC7 viewer Jose Quinteros captured the crash on video. He told ABC7 that he was driving on the northbound side of the freeway heading home to Santa Ana when he noticed a plane that appeared out of control, and that's when he started recording.

Witness Cassie Corsaro said immediately after the crash, she saw bystanders rush to the scene.

"Most of the people were getting out of their cars, running to the scene. I know one guy ran back to his car to grab a bottle of water. Someone needed water. They were doing everything that they could to help the people that were hurt," Corsaro said.

A witness shared video of the fiery aftermath of a plane crash on the 405 Freeway near the John Wayne Airport in Santa Ana on Friday.

The freeway was shut down in both directions at MacArthur due to crash debris. The northbound side was reopened around 10 a.m., the airport confirmed on Twitter.

The carpool lanes on the southbound side reopened just before 4 p.m. as authorities worked to load the wreckage onto a tow truck.

The full freeway was reopened around 4:45 p.m.

The plane involved in the 405 Freeway crash is seen on FlightAware.com.

The California Highway Patrol said a total of three vehicles on the southbound lanes and one vehicle on the northbound lanes struck components of the plane following the wreck.

The extent of the injuries were not known. No fatalities were reported.

According to records, the last time this plane was in the air was Thursday when it flew from John Wayne to Ontario, then back to John Wayne. The National Transportation Safety Board will be investigating the crash.