Previous GeneCards Identifiers for RN7SL290P Gene

Summaries for RN7SL290P Gene

GeneCards Summary for RN7SL290P Gene

RN7SL290P (RNA, 7SL, Cytoplasmic 290, Pseudogene) is a Pseudogene, and is affiliated with the SRP RNA class.

fRNAdb sequence ontologies for RN7SL290P Gene

Metazoan signal recognition particle RNA: The signal recognition particle (SRP) is a universally conserved ribonucleoprotein. It is involved in the co-translational targeting of proteins to membranes. The eukaryotic SRP consists of a 300-nucleotide 7S RNA and six proteins: SRPs 72, 68, 54, 19, 14, and 9. Archaeal SRP consists of a 7S RNA and homologues of the eukaryotic SRP19 and SRP54 proteins. Eukaryotic and archaeal 7S RNAs have very similar secondary structures, as represented by this family. Eight helical elements fold into the Alu and S domains, separated by a long linker region [1,2]. The Alu domain is thought to mediate the peptide chain elongation retardation function of the SRP [1]. The universally conserved helix which interacts with the SRP54 M domain mediates signal sequence recognition [2,3]. In eukaryotes and archaea, the SRP19-helix 6 complex is thought to be involved in SRP assembly and stabilises helix 8 for SRP54 binding [1]. The Signal Recognition Particle Database (SRPDB) [4] provides compilations of SRP components, with phylogenetic data and structural illustrations. Many sequences below the threshold for this family are clearly closely related, but are most likely to be SRP RNA derived pseudogenes. The human genome in particular is known to contain a large amount of SRP RNA related sequence, including Alu repeats. While the threshold of this family is set high so as to minimise the number of hits to such regions, it is likely that some remain.

Paralogs for RN7SL290P Gene

No data available for
Paralogs
for RN7SL290P Gene

Variants for RN7SL290P Gene

Relevant External Links for RN7SL290P Gene

No data available for
Polymorphic Variants from UniProtKB/Swiss-Prot ,
Sequence variations from dbSNP and Humsavar ,
Structural Variations from Database of Genomic Variants (DGV) and
Variation tolerance
for RN7SL290P Gene

Disorders for RN7SL290P Gene

No disorders were found for RN7SL290P Gene.

No data available for
MalaCards ,
UniProtKB/Swiss-Prot ,
Genatlas and
External Links
for RN7SL290P Gene