The BioLeonhardt MyoStim pump+stimulator is implanted in a patients abdomen. The micro pump is re-filled once a week with a cardio myogenic cocktail of stem cells, growth factors, micro RNAs and nutrient hydrogel. The pump contents are infused slowly into the damaged area of the heart over time via an infustion pacing lead. The bioelectric stimualtor causes controlled release of SDF-1, VEGF, Follistatin and Hepatocyte Growth Factor and controls the differention of cells into contractile muscle and mature blood vessels within heart scar tissue. The current translation studies are designed to prove out ability to fully regenerate a damaged heart over a 36 month course of treatment. SDF-1 is a stem cell homing factor, VEGF grows blood vessels, Follistatin grows muscle and Hepatocyte Growth Factor prevents arrhythmias.

Leonhardt Ventures, the parent of BioLeonhardt MyoStim, and its team of collaborating research scientists have been studying stem cell based regeneration of hearts since 1988 and has helped raise and put to work over $100 million to date for developing heart, cardiovascular and other organ regeneration and healing products.

BioLeonhardt MyoStim is being incubated in the Leonhardt Ventures’ Cal-X Stars Business Accelerator, Inc www.calxstars.com in Santa Monica and Santa Rosa, California.

Stem Cell Bra – www.stemcellbra.com – the world’s first women’s bra designed to recruit her own stem cells with a homing signal and to build new breast tissue without surgery – patent pending. Clinical safety and efficacy test results pending.

Tisugen Therapeutics – joint healing and regeneration and arthritis treatment with electric acupuncture and stem cells (this startup is in the UNIC STIC Incubator in Santa Rosa, CA see www.uncm.edu where Leonhardt serves on the board).

About The 2015 World Stem Cell Summit — (WSCS 15) – http://worldstemcellsummit.com/agenda-day/december-12/ -being held at Hyatt Regency in Atlanta, Georgia is an engine for discovery, funding and commercialization. Planned by and for the stem cell and regenerative medicine community, the Summit brings global stakeholders together to solve global challenges. The goal of the summit is to accelerate the discovery and development of lifesaving cures and therapies. The summit builds a foundation to advance cell therapies by establishing a supportive environment of regulation, legislation, financing, reimbursement and patient advocacy.

About Leonhardt Ventures: Since 1982 Leonhardt Ventures has a strong history of inventing, developing, backing and bringing to market leadership products for treating heart and cardiovascular disease. Over 240,000 patients have been treated to date with Leonhardt inventions. Leonhardt Venture’s started the Cal-X Stars Business Accelerator in 2012 to guide forward cardiovascular and social good impact innovations over a 5 year period.

About Howard Leonhardt: Inventor with over 21 patents for treating cardiovascular disease. Serial entrepreneur founding over 30 startups. 1980’s led development of turn key cardiac cath labs, cardiovascular balloon catheters, drug and radiation delivery catheters and intravascular lung. 1990’s developed and patented leading endovascular stent graft and percutaneous heart valve systems. Stent graft captured 70% world market share for repairing thoracic aortic aneurysms without surgery. Developed and patented first stem cell delivery catheter – ProCell. 2000’s – launched first clincial trials for stem cell repair of damaged hearts. Developed and patented biological pacemaker. Introduced first cardiovascular genetic test on U.S. market. 2010’s – Developed and patented full lineup of bioelectric stimulation devices for directing stem cell regeneration and repair of damaged organs and for improving blood flow and healing. Developed first implantable, programmable, re-fillable stem cell pump + electrical stimulator combination devices for organ regeneration. Developed patent pending first Stem Cell Bra. Serves as co-leader and state spokesperson for Startup California for The JOBS ACT and Crowdfunding. Chairman of The California Stock Exchange TM www.calstockexchange.com. Founder of The Kindheart Lionheart INSPIRATIONAL WORKS TV Network www.kindheartlionhearttv.com. Serves on the board of the Cell Therapy Foundation – http://www.celltherapyfoundation.org/About-Us/Advisory-Board/Howard-Leonhardt and numerous other boards including UCLA Bioengineering, USC Center for Technology & Innovation Pediatric, University of Northern California Science & Technology Innovation Center and the University of Florida Center for Entrepreneurship and Innovation since 2000. He is testing the waters for a 2018 run for the Lt. Governor’s office in California which appoints 5 of the 12 board members for the California Institute of Regenerative Medicine (CIRM). He and his son Ryan have produced Leonhardt Vineyards wines in California since 2005 www.leonhardtvineyards.com

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