The SHM33 monoclonal antibody reacts with human CD323, which is also known as Junctional Adhesion Molecule (JAM) 3. A member of the Ig superfamily of transmembrane proteins, CD323 is expressed on endothelial and epithelial cells, smooth muscle cells, peripheral nerves, platelets, and some B cells. In addition, this receptor is expressed on VEGF and histamine-stimulated endothelial cells, as well as on activated T cells. CD323 is involved in neutrophil transmigration during inflammation, angiogenesis, cell polarity, and nerve conduction. CD323 interacts homo- and heterotypically with beta2 and beta3 integrins, JAM2, and the viral receptor CAR.