It can't work as it's missing the bus arbitration pins (needed for DMA and Blitter) as well as the 6800 family interface (ACIA).
Also the MC68SZ328 (aka DragonBall VZ) is going to be EOL soon (the NXP page says "No longer recommended for new designs" (aka no longer manufactured).
Add to this that it's only available in BGA package (MC68SZ328 for the 66MHz) .. the MC68VZ328 come in a TQFP144
So even if it's close to a 68000 it unfortunately can't be use in place of a 68000.