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Abstract

To the editor: Recent studies (1-3) have indicated that levels of factor VIII are increased in chronic renal disease. One study (3) in which patients were seen over a period of 4 years showed that increased factor VIII levels at the time of diagnosis were associated with deteriorating renal functions, progressive renal disease, and poor prognosis. To explore these prognostic implications, we measured factor VIII levels in 32 patients (mostly children) who underwent percutaneous renal biopsies for nephrosis, disseminated lupus erythematosus with renal involvement, and vasculitis (anaphylactoid purpura) with renal involvement. The investigation of each child included factor VIII procoagulant