In cervical cancer HPV infection and disruption of mechanisms involving cell growth differentiation and apoptosis are strictly associated with tumor progression and invasion. On the other hand cell viability was almost totally recovered with dipyridamole an adenosine transporter inhibitor. Moreover ATP-induced apoptosis and signaling-p53 increase AMPK activation and PARP cleavage-as well as autophagy induction were […]

BACKGROUND Pluripotent stem cells have been derived from a variety of sources such as from the inner cell mass of preimplantation embryos from primordial germ cells from teratocarcinomas and from male germ cells. methods for the differentiation of ES cells to specific cell types. Another more stringent way to determine pluripotency of ES cells is […]

The cycling properties of mammary stem and progenitor cells is not well understood. progesterone amounts are high. The mouse mammary epithelium comprises two general lineages of cells luminal and basal that are arranged to create some ducts that drain alveoli during lactation. The type from the stem cell(s) that maintain this epithelium is normally controversial. […]

Background Subsets of cells with stem-like properties have been previously isolated from individual epithelial malignancies and their resistance to apoptosis-inducing stimuli continues to be linked to carcinoma recurrence and treatment failing. head and throat prostate and breasts individual carcinomas (n = 7) and from regular individual dental mucosa (n = 5) had been exposed to […]

Lapatinib is dynamic at the ATP-binding site of tyrosine kinases that are associated with the human epidermal growth factor receptor (EGFR Her-1 or ErbB1) and Her-2. these transporters although a small synergetic effect was observed in combining lapatinib and conventional chemotherapeutic agents in parental sensitive MCF-7 or S1 cells. Lapatinib alone however did not significantly […]

Metastatic cancer cells for many cancers are known to have modified cytoskeletal properties in particular to be more deformable and contractile. combined cell lines showing a more mesenchymal-like morphology while the fourth showing a change towards a more rounded morphology. A neural network algorithm could distinguish between samples of the less metastatic cells from your […]