STRING allows inspection of the interaction evidence for any given network. Choose any of the viewers above (disabled if not applicable in your network).

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:query proteins and first shell of interactors

white nodes:second shell of interactors

Node Content

empty nodes:proteins of unknown 3D structure

filled nodes:some 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

slmA

Nucleoid occlusion protein; Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (209 aa)

Predicted Functional Partners:

UMN179_00944

Deoxyuridine 5’-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism- it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (150 aa)

0.895

UMN179_00942

Hypothetical protein (75 aa)

0.893

UMN179_00945

Decarboxylase/phosphopantothenate synthase (409 aa)

0.889

UMN179_00946

DNA repair protein RadC (221 aa)

0.676

UMN179_00941

cAMP-regulatory protein (218 aa)

0.671

UMN179_00940

Methyltransferase domain-containing protein (251 aa)

0.614

UMN179_01657

SoxR reducing system protein RseC (144 aa)

0.544

UMN179_00883

Hypothetical protein (196 aa)

0.524

UMN179_00262

Hypothetical protein (178 aa)

0.458

lexA

LexA repressor protein; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (213 aa)

a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1

node2

node1 accession

node2 accession

node1 annotation

node2 annotation

score

UMN179_00262

UMN179_00883

UMN179_00262

UMN179_00883

Hypothetical protein

Hypothetical protein

0.721

UMN179_00262

UMN179_00942

UMN179_00262

UMN179_00942

Hypothetical protein

Hypothetical protein

0.599

UMN179_00262

slmA

UMN179_00262

UMN179_00943

Hypothetical protein

Nucleoid occlusion protein; Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions

0.458

UMN179_00883

UMN179_00262

UMN179_00883

UMN179_00262

Hypothetical protein

Hypothetical protein

0.721

UMN179_00883

UMN179_00942

UMN179_00883

UMN179_00942

Hypothetical protein

Hypothetical protein

0.531

UMN179_00883

slmA

UMN179_00883

UMN179_00943

Hypothetical protein

Nucleoid occlusion protein; Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions

0.524

UMN179_00940

UMN179_00941

UMN179_00940

UMN179_00941

Methyltransferase domain-containing protein

cAMP-regulatory protein

0.807

UMN179_00940

UMN179_00942

UMN179_00940

UMN179_00942

Methyltransferase domain-containing protein

Hypothetical protein

0.612

UMN179_00940

UMN179_00944

UMN179_00940

UMN179_00944

Methyltransferase domain-containing protein

Deoxyuridine 5’-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism- it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA

0.621

UMN179_00940

UMN179_00945

UMN179_00940

UMN179_00945

Methyltransferase domain-containing protein

Decarboxylase/phosphopantothenate synthase

0.617

UMN179_00940

UMN179_00946

UMN179_00940

UMN179_00946

Methyltransferase domain-containing protein

DNA repair protein RadC

0.464

UMN179_00940

slmA

UMN179_00940

UMN179_00943

Methyltransferase domain-containing protein

Nucleoid occlusion protein; Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions

0.614

UMN179_00941

UMN179_00940

UMN179_00941

UMN179_00940

cAMP-regulatory protein

Methyltransferase domain-containing protein

0.807

UMN179_00941

UMN179_00942

UMN179_00941

UMN179_00942

cAMP-regulatory protein

Hypothetical protein

0.679

UMN179_00941

UMN179_00944

UMN179_00941

UMN179_00944

cAMP-regulatory protein

Deoxyuridine 5’-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism- it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA

0.666

UMN179_00941

UMN179_00945

UMN179_00941

UMN179_00945

cAMP-regulatory protein

Decarboxylase/phosphopantothenate synthase

0.672

UMN179_00941

UMN179_00946

UMN179_00941

UMN179_00946

cAMP-regulatory protein

DNA repair protein RadC

0.443

UMN179_00941

slmA

UMN179_00941

UMN179_00943

cAMP-regulatory protein

Nucleoid occlusion protein; Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions

0.671

UMN179_00942

UMN179_00262

UMN179_00942

UMN179_00262

Hypothetical protein

Hypothetical protein

0.599

UMN179_00942

UMN179_00883

UMN179_00942

UMN179_00883

Hypothetical protein

Hypothetical protein

0.531

page 1 of 3

Network Stats

Network Stats analysis is still ongoing, please wait ...

Functional enrichments in your networkNote: some enrichments may be expected here (why?)

Enrichment analysis is still ongoing, please wait ...

Statistical background

For the above enrichment analysis, the following statistical background is assumed: