SATURN - 2nd line chemo combo for pain paliation - augment registration strategy. got protocol change, "will carefully monitor" its effect on previous pt accrual problems (this is very different from saying we already see an uptick)new emphasis on the fact that OS is main trial and pain is supportive in the wake of EXEL disaster this week

NSCLC - we and teva continue to revise development plan for this indication. we will provide guidance on timing on initiation when available [so no progress since 2q11 cc]

OGX-427

randomized IST in chemo naive CRPC, started 9/2011, PSA progression is primary endpoint ("imperfect" metric, but useful PD tool for certain drug candidates, such as 427 based on its MOA

preliminary data has been submitted to 2012 ASCO-GU symposium february 2-4, 2012

this drug's action on AR signaling is still relvant despite other advances (abiraterone and mdv-3100) being avail to pts, because reactivation of AR represents possible contribution to disease progression - ratioanle for combo with these AR inhibitors

MDVN news - if they get approval, how would that impact 2nd line strategy? clearly that data was very positive for prostate cancer patients, congratulations to them. We see direct impact and benefits for OGXI programs:**Custisen - preclincal data presented this year showed synergy w/ MDV-3100, presents opportunity "should ogxi and teva decide to go down that path"**OGX-427 - shares biologic impact on androgen receptor (AR) itself, but interacts with AR differently HSP27 chaperone escorts AR into nucleus.

plans for other combos? zytiga? It would take time to get 3100 thru regulatory process. hard for us to discuss re custirsen without teva, so we can't speak to that with talking to them. OGX-427 randomized data in prechemo space will be presented soon, hope we see intro of AR-targeting agents like abiraterone and MDV-3100 so we can target that pathway too. These are now being used later in disease progression, makes it easier to do those studies. But it will be awhile before MDV-3100 is available for other clinical studies.

recent EXEL experience in pain...i know you have SPA...how is FDA looking at your compound differently? We certainly had many questions after that incident, and it is important to draw differences. We have two tirals we presented to FDA, one for OS, second for durable pain palliation. Consistent with our comments, if you're going to demonstrate pain paliation as primary effect, you have to also show anticancer activity (and for prostate cancer this tpyically requires surivial endpoints). It is not a big surpirse that FDA would want to combine pain with another endpoint. We happen to be doing it thru 2 separate trials. FDA response is consitent with and reflected in our development program with an SPA granted from FDA for both trials.