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Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:query proteins and first shell of interactors

white nodes:second shell of interactors

Node Content

empty nodes:proteins of unknown 3D structure

filled nodes:some 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

RB2654_07811

Biotin carboxyl carrier protein, AccB (166 aa)

Predicted Functional Partners:

RB2654_07816

Acetyl-CoA carboxylase (448 aa)

0.999

RB2654_03049

Malonyl CoA-acyl carrier protein transacylase (297 aa)

0.998

accD

Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta ; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (333 aa)

0.987

accA

Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha ; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (321 aa)

0.984

RB2654_01380

Biotin--acetyl-CoA-carboxylase ligase (250 aa)

0.969

fabH

Beta-ketoacyl-ACP synthase III ; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and/or straight-chain of fatty acids (319 aa)

a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1

node2

node1 accession

node2 accession

node1 annotation

node2 annotation

score

RB2654_01225

RB2654_01380

RB2654_01225

RB2654_01380

Methylcrotonyl-CoA carboxylase, alpha subunit

Biotin--acetyl-CoA-carboxylase ligase

0.794

RB2654_01225

RB2654_03049

RB2654_01225

RB2654_03049

Methylcrotonyl-CoA carboxylase, alpha subunit

Malonyl CoA-acyl carrier protein transacylase

0.694

RB2654_01225

RB2654_07811

RB2654_01225

RB2654_07811

Methylcrotonyl-CoA carboxylase, alpha subunit

Biotin carboxyl carrier protein, AccB

0.922

RB2654_01225

RB2654_07816

RB2654_01225

RB2654_07816

Methylcrotonyl-CoA carboxylase, alpha subunit

Acetyl-CoA carboxylase

0.632

RB2654_01225

RB2654_08797

RB2654_01225

RB2654_08797

Methylcrotonyl-CoA carboxylase, alpha subunit

Methylmalonyl-CoA mutase

0.919

RB2654_01225

RB2654_09049

RB2654_01225

RB2654_09049

Methylcrotonyl-CoA carboxylase, alpha subunit

Methylmalonyl-CoA mutase-like protein

0.919

RB2654_01225

RB2654_17346

RB2654_01225

RB2654_17346

Methylcrotonyl-CoA carboxylase, alpha subunit

Succinyl-CoA ligase [ADP-forming] subunit alpha

0.600

RB2654_01225

accA

RB2654_01225

RB2654_16746

Methylcrotonyl-CoA carboxylase, alpha subunit

Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha ; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA

0.834

RB2654_01225

accD

RB2654_01225

RB2654_11518

Methylcrotonyl-CoA carboxylase, alpha subunit

Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta ; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA

0.828

RB2654_01225

fabH

RB2654_01225

RB2654_04884

Methylcrotonyl-CoA carboxylase, alpha subunit

Beta-ketoacyl-ACP synthase III ; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and/or straight-chain of fatty acids

0.588

RB2654_01380

RB2654_01225

RB2654_01380

RB2654_01225

Biotin--acetyl-CoA-carboxylase ligase

Methylcrotonyl-CoA carboxylase, alpha subunit

0.794

RB2654_01380

RB2654_03049

RB2654_01380

RB2654_03049

Biotin--acetyl-CoA-carboxylase ligase

Malonyl CoA-acyl carrier protein transacylase

0.796

RB2654_01380

RB2654_07811

RB2654_01380

RB2654_07811

Biotin--acetyl-CoA-carboxylase ligase

Biotin carboxyl carrier protein, AccB

0.969

RB2654_01380

RB2654_07816

RB2654_01380

RB2654_07816

Biotin--acetyl-CoA-carboxylase ligase

Acetyl-CoA carboxylase

0.876

RB2654_01380

accA

RB2654_01380

RB2654_16746

Biotin--acetyl-CoA-carboxylase ligase

Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha ; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA

0.510

RB2654_01380

accD

RB2654_01380

RB2654_11518

Biotin--acetyl-CoA-carboxylase ligase

Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta ; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA

0.525

RB2654_01380

fabH

RB2654_01380

RB2654_04884

Biotin--acetyl-CoA-carboxylase ligase

Beta-ketoacyl-ACP synthase III ; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and/or straight-chain of fatty acids

0.636

RB2654_03049

RB2654_01225

RB2654_03049

RB2654_01225

Malonyl CoA-acyl carrier protein transacylase

Methylcrotonyl-CoA carboxylase, alpha subunit

0.694

RB2654_03049

RB2654_01380

RB2654_03049

RB2654_01380

Malonyl CoA-acyl carrier protein transacylase

Biotin--acetyl-CoA-carboxylase ligase

0.796

RB2654_03049

RB2654_07811

RB2654_03049

RB2654_07811

Malonyl CoA-acyl carrier protein transacylase

Biotin carboxyl carrier protein, AccB

0.998

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Network Stats

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Functional enrichments in your networkNote: some enrichments may be expected here (why?)

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Statistical background

For the above enrichment analysis, the following statistical background is assumed: