By the time of the Battle of Stalingrad, the 2nd Guards Army had become one of the most powerful units in the Red Army. The 2nd Guards Army appeared on the scene after the SovietOperation Uranus had successfully encircled the German Sixth Army at Stalingrad in November 1942. In December 1942, as preparations started for Operation Saturn, the 2nd Guards Army was ordered by Joseph Stalin to prepare for an attack on Rostov. The assault and capture of Rostov was the ultimate goal of the Red Army for Operation Saturn.

After Operation Wintergewitter had ended, Soviet forces in the South-West Front led by the First Guards Army successfully launched Operation Little Saturn against the Italian Eighth Army. Following this, the 2nd Guards Army and the 51st Army launched another counter-offensive, this time against Army Group Hoth, in the days before Christmas 1942. Not only had Operation Wintergewitter been halted, the Red Army had made substantial gains against Army Group Hoth, Army Group Don, and also Army Group A in the Caucasus region that month.

The 2nd Guards Army made a very significant contribution to the Soviet halt of Operation Wintergewitter and the successful counter-attacks that followed.

In February 1944, the Army relocated to the area of the Perekop Isthmus. The Crimean Offensive was launched across the Perekop Isthmus on 8 April 1944 by elements of the 2nd Guards Army and 51st Army, under the 4th Ukrainian Front.[2] In cooperation with other troops of the 4th Ukrainian Front and the Black Sea Fleet, Sevastopol was liberated on May 9, 1944. In May and June the 2nd Guards Army was relocated to the area of the cities Dorogobuzh Elnya. On May 20, was moved to the Reserve of the Supreme High Command and on July 8 the unit was a part of the 1st Baltic Front. By that time, it consisted of the 11th and the 13th and 54th Guards Rifle Corps. In this structure, on 5–20 July 1944 took part in the Vilnius Offensive/operation at the end of July, and in the Siauliai offensive reflect enemy counterattacks west and north-west of Siauliai. In October, the 2nd Guards Army participated in the Memel offensive. On December 20 it was reassigned to the 3rd Belorussian Front.

During the East Prussian Offensive in January–April 1945, the army broke through long-term German strategic defenses, eliminated in conjunction with other troops surrounded the front of its group (south-west of Königsberg and Samland group).