Once aboard, Sloane was treated for severe radiation poisoning, but was revived by the medical staff when the Borg overran the Enterprisesickbay. Retreating to a Jefferies tube, Sloane slipped away from Doctor Crusher and her team, eventually coming across Picard. She held the Captain hostage until he was able to convince her that she was not in Montana anymore. Relinquishing the phaser to Picard, Sloane accompanied the captain in his effort to retake the ship.

Finally returning to the bridge of the Enterprise, Sloane was present for a heated exchange between Picard and one of his officers, Lieutenant Commander Worf. Following the captain into the adjacent observation lounge, Sloane chastised Picard for his actions, comparing him to Captain Ahab of Herman Melville's Moby Dick, despite the fact that she had never read it. Sparring verbally with the captain, Sloane was able to convince Picard to relent and follow Worf's recommendation to engage the ship's auto-destruct system.

Sloane departed the Enterprise along with the remainder of its crew in an escape pod bound for Gravett Island. She later reunited with Picard and his command crew, as well as Zefram Cochrane, back in Montana on the night of April 5, 2063. There she witnessed Cochrane make his historic First Contact with a group of Vulcans. (Star Trek: First Contact)

In early drafts of the film, her character was called Ruby, a photographer and X-ray technician who was instrumental in helping Jean-Luc Picard repair the damaged Phoenix. The name was instead used for one of the Dixon Hill characters seen in the film.