The GATA zinc-finger transcription factor GATA4 is important for endoderm and cardiac development. Anna-Katerina Hadjantonakis and colleagues have generated a novel nuclear localized fluorescent reporter that labels nuclei of Gata4 expressing cells and is suitable for time-lapse imaging and single cell analyses in the mouse.

PEPCK1 is ubiquitinated by E3 ubiquitin ligase UBR5, which was thought to be facilitated by the acetylation of Lys70, Lys71 and Lys594 in PEPCK1. By assaying UBR5 HECT domain truncation variants Zongchao Jia and team showed this is not the case, the N-terminal lobe of the UBR5 HECT domain is largely responsible for interacting with PEPCK1. They then identified PEPCK1 ubiquitination sites.

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Recent experimental biology highlights in BiO – Mark I. McCormick and colleagues show that fish exhibit water flow-induced changes in their fast-start escape performance, likely due to an in situ training effect and/or selection for faster performance phenotypes in areas with high flow speed.

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Pavithran Ravindrandiscusses the preprint from Leor Weinberger and colleagues, who created a new anti-viral drug modality that uses a 28 base pair piece of DNA to have a virus reduce its own progression without any sign of resistance.