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Evening primrose oil (E.P.O) is cold-pressed and produced without the use of any solvents. Used for centuries as nutritional support for a wide range of physiological functions, several studies have indicated that EPO may help support the look and feel of healthy skin. A clinical trial reported that EPO supported healthy skin through a modulation of IFN-gamma. Another study revealed that EPO promoted skin health and led to a more favorable shift in eicosanoid metabolism. Other studies suggest that EPO may support healthy lipid metabolism and may provide oxidative protection by promoting glutathione reductase and transferase activities. A clinical trial reported that GLA in combination with EPA/DHA significantly promoted healthy cardiovascular function in women. Additionally, EPO may potentially be supportive of premenstrual comfort.