Targeting ‘Achilles’ heel’ could supercharge breast cancer treatment

(Walter and Eliza Hall Institute) A new class of anti-cancer agents targeting cancer cells' 'Achilles' heel' could help to supercharge breast cancer treatment, improving outcomes for the most aggressive types of breast cancer.Combining anti-cancer compound S63845 with currently used cancer drugs was more effective in killing triple negative breast cancers and HER2-positive breast cancers.This is the first time the S63845 compound has been shown to be effective in breast cancer, suggesting it should be investigated in clinical trials.