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ABSTRACT: Although anal cancer is rare, incidence rates are rising in the United States. Recognizing and screening high-risk patients can improve management. Vaccination may also play a role in the prevention of HPV-related anal cancer, but more research is needed.

Erich Grant is an instructor in the PA program at Wake Forest School of Medicine in Winston-Salem, North Carolina. Jimzon Javier, Phillip Kelley, Tia L. Oliveri, and Lucia Lopez are recent graduates of the PA program at Wake Forest School of Medicine. The authors have indicated no relationships to disclose relating to the content of this article.