Plus d’anticorps contre CD56 partenaires d’interaction

Human Neural Cell Adhesion Molecule 1 (NCAM1) interaction partners

Findings provide evidence that NCAM/CD56 is a pathogen recognition receptor and plays a functional role for the NK cell cytotoxicity in the innate immune response. NK cells directly interact with A. fumigatus via CD56 and that CD56 is re-organized and accumulated at this interaction site time-dependently.

Large cell transformation and aberrant CD56 expression were more frequent in patients with Mycosis fungoides (MF) in Taiwan compared to those in the West.

CD56 is a potentially good immunohistochemical marker for differentiating papillary thyroid carcinoma from other benign follicular lesions of the thyroid

TROP-2, SLP-2 and CD56 were effective diagnostic markers for PTC, especially when they were combined to use.

evaluation of the diagnostic value of emerin and CD56 in papillary thyroid carcinoma, using immunohistochemistry

Plasma levels of NCAM-1 were found to be lower in coronary artery disease patients compared to controls.

The expression of CD56 was analyzed in 74 samples of primary MM cells collected from patients before they received bortezomib plus dexamethasone therapy. Expression of NCAM was lower among patients who responded poorly. In vitro expression of NCAM induced by transfection of MM cells enhanced their sensitivity to Btz treatment by causing accumulation of polyubiquitinated proteins.

Results show that the conjugate selectively depleted the CSC population of the tumors and effectively inhibited tumor growth without causing toxicity. We propose that the NCAM-targeted conjugate could be an effective therapeutic for Wilms tumor.

CD200 and/or CD56 positive expression in B-ALL at diagnosis suggest a poor prognosis and may be associated with biological aggressiveness.

This study concludes that the cytotoxic action of CD56+ fraction of cytokine-induced killer cells against a K562 cell line is mainly due to the natural killer cells.

NCAM1 was up-regulated in the malignant Middle Cerebral Artery Infarction.

This supports the conclusion that a lower proportion of CD56(bright) natural killer regulatory cells results in the high rate of chronic graft-versus-host disease seen in filgrastim-stimulated apheresis peripheral blood.

inhibiting NCAM1 would be cardioprotective, counteract the pathological action of TGFbeta1 and reduce heart failure severity.

Increased polysialylation of the NCAM has been found in a transgenic mouse model of sialuria.

study delineates a mechanism in which NCAM promotes ephrin-A5-dependent clustering of EphA3 through interaction of the NCAM Ig2 domain and the EphA3 CRD, stimulating EphA3 autophosphorylation and RhoA signaling necessary for growth cone repulsion in GABAergic interneurons in vitro, which may extend to remodeling of axonal terminals of interneurons in vivo.

data provided molecular details about the interaction between HuPrP and the NCAM fibronectin domain, and revealed a new role of PrP(C) N terminus as a dynamic and functional element responsible for protein-protein interaction.

Results demonstrate that the early development of calbindin-positive periglomerular interneurons depends on the presentation of polysialic acid on NCAM and requires the activity of both St8sia2 and St8sia4

NCAM plays significant roles in the adult visual system in establishing normal retinal anatomy, physiology and function, and in maintaining vision during aging.

induced expression of L1CAM or PSA-NCAM in the iPSC-derived DA neurons cannot completely restore the neurite outgrowth potential that was reduced in these DA neurons as a consequence of epigenetic aberrations resulting from the iPSC reprogramming process.

The data of this study demonstrated the importance of NCAM for the development and functional activity of the BDNF signaling and serotonergic neurotransmission

PrP-deficient cells fail to undergo NCAM1 polysialylation during EMT.

NCAM-140 significantly promoted cell proliferation, motility and migration, while polysialylation of NCAM-140 catalyzed by STX, but not by PST, enhanced NCAM-mediated cell migration, but not cell proliferation or motility.

changes of NCAM expression in the late postnatal and mature forebrain determine avoidance behaviour and serotonin (5-HT)1A receptor signalling.

PrP plays a critical role in neuronal differentiation of neuralprecursor cells and suggest that this function is, at least in part, NCAM-dependent.

This study propose that presynaptic NCAM bridges a critical link between the SV cycle and the functional expansion of synaptic territory through the regulation of L-VDCCs.

findings suggest that NCAM-mediated processes are involved in both novelty/stress-related emotional behavior and in cognitive function during spatial learning

CD56 (NCAM1) profil antigène

Profil protéine

This gene encodes a cell adhesion protein which is a member of the immunoglobulin superfamily. The encoded protein is involved in cell-to-cell interactions as well as cell-matrix interactions during development and differentiation. The encoded protein has been shown to be involved in development of the nervous system, and for cells involved in the expansion of T cells and dendritic cells which play an important role in immune surveillance. Alternative splicing results in multiple transcript variants.