Databases

Coexpression

Proteins whose genes are observed to be correlated in expression, across a large number of experiments.

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Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:query proteins and first shell of interactors

white nodes:second shell of interactors

Node Content

empty nodes:proteins of unknown 3D structure

filled nodes:some 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

hemD

Uroporphyrinogen-III synthase (251 aa)

Predicted Functional Partners:

rnpA

Protein C5 ; RNaseP catalyzes the removal of the 5’-leader sequence from pre-tRNA to produce the mature 5’-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5’-leader sequence and broadening the substrate specificity of the ribozyme (165 aa)

Methionine adenosyltransferase ; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme (430 aa)

0.852

HMPREF9018_0194

Uncharacterized protein (199 aa)

0.768

HMPREF9018_1876

Uncharacterized protein (148 aa)

0.745

tyrS

Tyrosyl-tRNA synthetase ; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction- tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (432 aa)

a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1

node2

node1 accession

node2 accession

node1 annotation

node2 annotation

score

HMPREF9018_0194

HMPREF9018_0283

HMPREF9018_0194

HMPREF9018_0283

Uncharacterized protein

Uncharacterized protein

0.742

HMPREF9018_0194

HMPREF9018_0882

HMPREF9018_0194

HMPREF9018_0882

Uncharacterized protein

Uncharacterized protein

0.737

HMPREF9018_0194

HMPREF9018_1339

HMPREF9018_0194

HMPREF9018_1339

Uncharacterized protein

Uncharacterized protein

0.683

HMPREF9018_0194

HMPREF9018_1876

HMPREF9018_0194

HMPREF9018_1876

Uncharacterized protein

Uncharacterized protein

0.659

HMPREF9018_0194

hemD

HMPREF9018_0194

HMPREF9018_1097

Uncharacterized protein

Uroporphyrinogen-III synthase

0.768

HMPREF9018_0283

HMPREF9018_0194

HMPREF9018_0283

HMPREF9018_0194

Uncharacterized protein

Uncharacterized protein

0.742

HMPREF9018_0283

HMPREF9018_0882

HMPREF9018_0283

HMPREF9018_0882

Uncharacterized protein

Uncharacterized protein

0.575

HMPREF9018_0283

HMPREF9018_1339

HMPREF9018_0283

HMPREF9018_1339

Uncharacterized protein

Uncharacterized protein

0.708

HMPREF9018_0283

HMPREF9018_1876

HMPREF9018_0283

HMPREF9018_1876

Uncharacterized protein

Uncharacterized protein

0.400

HMPREF9018_0283

hemD

HMPREF9018_0283

HMPREF9018_1097

Uncharacterized protein

Uroporphyrinogen-III synthase

0.621

HMPREF9018_0882

HMPREF9018_0194

HMPREF9018_0882

HMPREF9018_0194

Uncharacterized protein

Uncharacterized protein

0.737

HMPREF9018_0882

HMPREF9018_0283

HMPREF9018_0882

HMPREF9018_0283

Uncharacterized protein

Uncharacterized protein

0.575

HMPREF9018_0882

HMPREF9018_1339

HMPREF9018_0882

HMPREF9018_1339

Uncharacterized protein

Uncharacterized protein

0.449

HMPREF9018_0882

HMPREF9018_1876

HMPREF9018_0882

HMPREF9018_1876

Uncharacterized protein

Uncharacterized protein

0.748

HMPREF9018_0882

hemD

HMPREF9018_0882

HMPREF9018_1097

Uncharacterized protein

Uroporphyrinogen-III synthase

0.636

HMPREF9018_1095

HMPREF9018_1098

HMPREF9018_1095

HMPREF9018_1098

Putative membrane protein insertion efficiency factor ; Could be involved in insertion of integral membrane proteins into the membrane

Uncharacterized protein

0.859

HMPREF9018_1095

hemD

HMPREF9018_1095

HMPREF9018_1097

Putative membrane protein insertion efficiency factor ; Could be involved in insertion of integral membrane proteins into the membrane

Uroporphyrinogen-III synthase

0.877

HMPREF9018_1095

metK

HMPREF9018_1095

HMPREF9018_1099

Putative membrane protein insertion efficiency factor ; Could be involved in insertion of integral membrane proteins into the membrane

Methionine adenosyltransferase ; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme

0.854

HMPREF9018_1095

rnpA

HMPREF9018_1095

HMPREF9018_1096

Putative membrane protein insertion efficiency factor ; Could be involved in insertion of integral membrane proteins into the membrane

Protein C5 ; RNaseP catalyzes the removal of the 5’-leader sequence from pre-tRNA to produce the mature 5’-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5’-leader sequence and broadening the substrate specificity of the ribozyme

0.877

HMPREF9018_1095

tyrS

HMPREF9018_1095

HMPREF9018_1094

Putative membrane protein insertion efficiency factor ; Could be involved in insertion of integral membrane proteins into the membrane

Tyrosyl-tRNA synthetase ; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction- tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)

0.656

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Network Stats

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Functional enrichments in your networkNote: some enrichments may be expected here (why?)

Enrichment analysis is still ongoing, please wait ...

Statistical background

For the above enrichment analysis, the following statistical background is assumed: