..This review describes the distribution of BDNF and trkB expressing cells in the forebrain, and the roles of estrogen and the BDNF-trkB neurotrophin system in Parkinson's disease, Alzheimer's disease and multiple sclerosis...

Guarding the blood-brain barrier: a role for estrogen in the etiology of neurodegenerative disease

..This article considers the disruption of the blood-brain barrier in Alzheimer's disease and forwards the hypothesis that estrogen may preserve neural health by maintaining the integrity of the blood-brain barrier...

Neurotrophin expression in the reproductively senescent forebrain is refractory to estrogen stimulation

..Since the two estrogen receptors have been shown to stimulate different signaling pathways, we hypothesize that estrogen acting through specific receptors may differentially influence the extent and direction of neurotrophin expression...

Differential effects of estrogen in the injured forebrain of young adult and reproductive senescent animals

..The paper will also review aging and reproductive age-related changes in the estrogen receptor (ER) systems, specifically ER-alpha, as a potential mechanism for estrogen's deleterious effects in the reproductive senescent animal...

Adverse effects of incorporating ketoprofen into established rodent studies

..These data suggest that the central inflammatory response to a systemic insult can be modulated by estrogen although the mechanism underlying the initiation of this response varies with reproductive age...

Estrogen's effects on central and circulating immune cells vary with reproductive age

..These results support the hypothesis that the hormonal decline that marks reproductive senescence leads to increased permeability of the blood-brain barrier, which is further exacerbated by estrogen treatment in specific regions...

The neurotoxic effects of estrogen on ischemic stroke in older female rats is associated with age-dependent loss of insulin-like growth factor-1

..These data support the hypothesis that stroke severity in older females is associated with decreased IGF-1 and further indicate that short-term postischemic IGF-1 therapy may be beneficial for stroke...

M K JezierskiDepartment of Human Anatomy and Medical Neurobiology, The Texas A and M University System Health Science Center, College Station 77843-1114, USAEndocrinology 142:2401. 2001

..In view of the disparate roles assigned to JNK, this latter finding suggests that estrogen pretreatment may preferentially direct neurotrophin-dependent JNK activation toward regeneration and plasticity rather than cell death...

Neurodegeneration in women

Farida SohrabjiDepartment of Human Anatomy and Medical Neurobiology, College of Medicine, Texas A and M University System Health Science Center, College Station, Texas, USAAlcohol Res Health 26:316-8. 2002

..Collectively, these data support the hypothesis that constitutive loss of barrier integrity in the forebrain during reproductive senescence may be due, in part, to the selective loss of tight junction proteins in endothelial junctions...

A high cholesterol diet elevates hippocampal cytokine expression in an age and estrogen-dependent manner in female rats

..The present data also support the hypothesis that 17beta-estradiol treatment to an ERalpha overexpressing system, such as the senescent brain, could reverse the normally observed beneficial effect of estrogen...