Description: GenWay Biotech, Inc.'s Rabbit Anti-Chicken Lysozyme Polyclonal Antibody, Unconjugated is a Rabbit Polyclonal antibody. The Rabbit Anti-Chicken Lysozyme Polyclonal Antibody, Unconjugated was generated using LYSOZYME as the antigen and it reacts with Chicken/Bird. This antibody has been shown to work in applications such as: Functional Assay, Other, Immunoprecipitation, ELISA, Western Blot.
Background: A general anti-lysozyme antibody for use in a wide variety of applications requiring high titer and specificity.Function: Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents.Catalytic Activity: Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.Subunit: Monomer.Disease: Defects in LYZ are a cause of amyloidosis type 8 (AMYL8) [MIM:105200]; also known as systemic non-neuropathic amyloidosis or Ostertag-type amyloidosis. AMYL8 is a hereditary generalized amyloidosis due to deposition of apolipoprotein A1, fibrinogen and lysozyme amyloids. Viscera are particularly affected. There is no involvement of the nervous system. Clinical features include renal amyloidosis resulting in nephrotic syndrome, arterial hypertension, hepatosplenomegaly, cholestasis, petechial skin rash.Miscellaneous: Lysozyme C is capable of both hydrolysis and transglycosylation; it shows also a slight esterase activity. It acts rapidly on both peptide-substituted and unsubstituted peptidoglycan, and slowly on chitin oligosaccharides.Similarity: Belongs to the glycosyl hydrolase 22 family [view classification].Products ID: 196847Accession Number: NP_000230.1SP Accession Number: P61626NCBI Name: Lysozyme COMIM: 105200, 153450Molecular Weight: 16537Cross-Reactivity: Cross-reacts with Chicken. Not yet tested in other species.Interaction: P50053, EBI-355360,EBI-1053974, Q38SD2, EBI-355360,EBI-1050422, P22392, EBI-355360,EBI-713693, Q15654, EBI-355360,EBI-742327, Q9P2S5, EBI-355360,EBI-1054904Storage: Keep as concentrated solution. Store at 4C short term. For extended storage aliquot and store at -20C or below. Avoid freeze-thaw cycles.Isotype: IgGImmunogen: Lysozyme from Hen Egg WhiteAntigen Species: ChickenSpecificity: Assay by immunoelectrophoresis resulted in a single precipitin arc against purified and partially purified Lysozyme from hen egg white.Positive Control: Assayed against 1.0 µg of Lysozyme from hen egg white in a standard sandwich ELISA using Peroxidase conjugated Affinity Purified anti-Rabbit IgG [H&L] (Goat) and (ABTS (2,2-azino-bis-[3-ethylbenthiazoline-6-sulfonic acid]) as a substrate for 30 minutes at room temperature. Target: LysozymeLocalization: SecretedConcentration: 10 mg/mlPurification Note: From polyclonal serum.Storage Buffer: 0.02M Potassium phosphate, 0.15M sodium chloride, pH7.2, containing 0.01% sodium azideApplication Note: A working dilution of 1:4,000 to 1:10,000 in immunoblot and immunoprecipitation is recommended. Not tested in other applications. Optimal titers for other applications should be determined by the researcher.Cellular Localization: Secreted collapse