GeneCards Summary for PUM3 Gene

UniProtKB/Swiss-Prot for PUM3 Gene

Inhibits the poly(ADP-ribosyl)ation activity of PARP1 and the degradation of PARP1 by CASP3 following genotoxic stress (PubMed:21266351). Binds to double-stranded RNA or DNA without sequence specificity (PubMed:25512524). Involved in development of the eye and of primordial germ cells (By similarity).

Function for PUM3 Gene

Products:

Molecular function for PUM3 Gene

UniProtKB/Swiss-Prot Function:

Inhibits the poly(ADP-ribosyl)ation activity of PARP1 and the degradation of PARP1 by CASP3 following genotoxic stress (PubMed:21266351). Binds to double-stranded RNA or DNA without sequence specificity (PubMed:25512524). Involved in development of the eye and of primordial germ cells (By similarity).

No data available for
Paralogs
for PUM3 Gene

Variants for PUM3 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for PUM3 Gene

The following alleles of HA-8 are known: HA-8R, HA-8P, HA-8PL, of which only HA-8R leads to specific cytotoxic T lymphocyte (CTL) recognition. The lack of CTL recognition of cells expressing HA-8P may be due to impaired transport associated with antigen processing. The sequence shown is that of HA-8R.