Dr. Busque

Researcher

Determinants of oncogenic penetrance of TET2 mutations in aging individuals

The incidence of blood cancers greatly increases with age. However, there is no test to identify individuals at risk. We have documented mutation in a gene called TET2 in a small proportion of aging individuals. Since this gene is frequently mutated in blood cancers of older people, we think that it may be a predisposing factor. To prove our hypothesis, we need to study a larger number of individuals and see if they develop such cancers with time. Fortunately, we have started our study 10-15 years ago with several thousand subjects. Therefore, we will be able to answer this question in a short lapse of time. If our hypothesis holds true, we will be able to identify individuals at risk of blood cancer as it is done for other cancers such as prostate, colon or breast.

Follow us

Newsletter subscription

This field is requiredEmail address

The Leukemia & Lymphoma Society of Canada (LLSC) is a voluntary health agency dedicated to blood cancers. We provide free information and support services to patients and caregivers. The LLSC mission: Cure leukemia, lymphoma, Hodgkin's disease and myeloma, and improve the quality of life of patients and their families.