The monoclonal antibody is directed against the CD63-antigen, a 53 kD glycoprotein, which is expressed in platelet lysosomes, that are located to the platelet surface upon activation with strong agonists. The antigen is also present in most peripheral blood cells (not in erythrocytes cells) and in many tissues; both surface and cytoplasmic locations are reported.

Form:

Liquid

Isotype:

IgG1

Recommend Usage:

The optimal working dilution should be determined by the end user.

Storage Buffer:

In 20 mM Tris, 150 mM NaCl, pH 8.0 (10 mg BSA, 0.001% thimerosal)

Storage Instruction:

Store at 4°C.

Note:

This product contains thimerosal: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. It may function as a blood platelet activation marker. Deficiency of this protein is associated with Hermansky-Pudlak syndrome. Also this gene has been associated with tumor progression. The use of alternate polyadenylation sites has been found for this gene. Alternative splicing results in multiple transcript variants encoding different proteins. [provided by RefSeq