Brood Mothers have large health pools, but low armor, making them vulnerable to most weapons. Brood Mothers have very high damage attacks that occur in pairs, one from each talon. They should be killed as quickly as possible, and from range. Nukes, OSOK, and Sonic Traps are excellent to disable or kill them.

A small swarm of Brood Mothers will attack after the Black Ops Battle during Eos's final wave. They can be fatal if players are not attentive.

Outside of Easy Company Brood Mothers are only seen on round 27 of Survival. Although, in extremely rare occurrences, Brood Mothers have been seen emerging from Spore Meteors