Triprolidine HCL
Synthesis Reference

Triprolidine HCL
Molecular Weight

Triprolidine HCL
Melting Point

Triprolidine HCL
H2O Solubility

Triprolidine HCL
State

Triprolidine HCL
LogP

3.729

Triprolidine HCL
Dosage Forms

Syrup; Tablet

Triprolidine HCL
Indication

For the treatment of hay fever, urticaria (hives), and other allergic systems.

Triprolidine HCL
Pharmacology

In allergic reactions an allergen interacts with and cross-links surface IgE antibodies on mast cells and basophils. Once the mast cell-antibody-antigen complex is formed, a complex series of events occurs that eventually leads to cell-degranulation and the release of histamine (and other chemical mediators) from the mast cell or basophil. Once released, histamine can react with local or widespread tissues through histamine receptors. Histamine, acting on H1-receptors, produces pruritis, vasodilatation, hypotension, flushing, headache, tachycardia, and bronchoconstriction. Histamine also increases vascular permeability and potentiates pain. Triprolidine, is a histamine H1 antagonist that competes with histamine for the normal H1-receptor sites on effector cells of the gastrointestinal tract, blood vessels and respiratory tract. It provides effective, temporary relief of sneezing, watery and itchy eyes, and runny nose due to hay fever and other upper respiratory allergies.

Triprolidine HCL
Patient Information

Stop taking triprolidine 4 days before you have an allergy skin test.
Drink water frequently or use ice chips, sugarless candy, or sugarless gum if dry mouth occurs. Coffee or tea may
reduce the common side effect of drowsiness.