CAR-T Pharmacological Study

Chimeric antigen receptor T (CAR-T) cell is one of the current leading immuno-therapy in cancer treatments. Increasing number of CAR-T involved clinical trials against CD19+ B cell lymphoblast leukemia have been conducted across multiple institutions and the outcomes are encouraging. With more CAR-T involved clinical trials in planning, preclinical pharmacological study of CAR-T cells will provide valuable information for the subsequent clinical studies and future therapies.

Creative Animodel offers comprehensive pharmacological study of CAR-T cell therapy using human tumor xenograft mouse or rat models. We provide customized services to help you design the experiments that best suite your study. With our experiences in animal model construction and preclinical studies, we will provide you with cost-effective services and quality data.

CAR-T preclinical studies we offer:

Pharmacokinetic study:
Pharmacokinetic study of CAR-T cells monitor the level and duration of CAR-T cells circulating in the blood stream. The longer CAR-T cells stays in blood circulation, the more effective each dose of CAR-T cells would be. In some cases, CAR-T cells were cleared out of the blood stream even before they could take effects, which leads to a failed treatment.