I created 100 CDs, each with one setup.exe file that automatically runs upon insertion.

With some of the CDs, when I explore the contents of the CD, the icon of the setup.exe file becomes that of the command prompt and running it gives me the following error:

The program is too big to fit in memory

This problem appears to be random: if I take an "afflicted" CD out of the first computer and put it into another, it autoruns as expected. If I then reset the first computer, it too works properly. But, putting it into yet another computer results in the same issue.

I am certain that malware is not causing this, as I am checking with different PCs and with fully updated definitions.