David
A Geier, Mark R Geier
MD PhD. Chronic
adverse reactions associated with hepatitis B vaccinationThe Annals of Pharmacotherapy 2002: Vol. 36,
No. 12, pp. 1970–1971.In conclusion, our study demonstrates that
adult HBV is statistically associated not only
with acute neuropathy, neuritis, myelitis, vasculitis, thrombocytopenia,
gastrointestinal disease, multiple sclerosis, and arthritis, but some of these
patients go on to develop chronic adverse reactions that persist for at least 1
year following HBV. These types of chronic adverse reactions following
adult HBV should be discussed with patients contemplating being immunized with
HBV and should be included in the differential diagnosis of those who develop
them following adult HBV.

Powell
HC, Mizisin AP, Wiley CA, Morey MK, Hughes RA. Relationship of
adjuvants and swine influenza vaccine to experimental neuropathy in rabbits.Acta Neuropathol (Berl). 1987;73(1):12-8.PMID: 3037840 [PubMed - indexed for
MEDLINE]
Experimental neuropathy, characterized by endoneurial edema and demyelination, was induced
by inoculating rabbits with a combination of Freund's complete adjuvant (FCA),
gangliosides, lecithin and cholesterol. A less severe demyelinating neuropathy could be
induced by treatment with FCA alone but no significant change could be elicited by
injection of swine influenza vaccine (SFV) alone. When FCA was combined with gangliosides,
lecithins, cholesterol and SFV, neuropathy occurred, but the changes were less severe than
if these agents were used without SFV. Sera were tested for myelin basic protein (MBP) and
galactocerebroside (GC) antibodies in each experimental group. Neither SFV alone nor SFV
combined with Freund's complete adjuvant, gangliosides, cholesterol and lecithin evoked
significant antibody titers to MBP or GC. However, rabbits inoculated with FCA,
gangliosides, lecithin and cholesterol had rising titers of antibody to both MBP and GC
over the 3-month experimental period. One rabbit inoculated with FCA alone had significant
antibody to MBP. The findings suggest that Freund's complete adjuvant alone can induce
demyelination in the peripheral nerves of rabbits and that SFV may modulate the immune
response acting either as an adjuvant or suppressant in the experimental demyelinating
disease.