Tapentadol ER Effective for Diabetic Peripheral Neuropathy Pain

the MPR take:

Tapentadol extended-release (ER), an opioid analgesic, is an effective treatment for patients who have chronic pain due to diabetic peripheral neuropathy (DPN), says a new study published in the journal Diabetes Care. In the study, 318 patients were randomized to receive either tapentadol ER or placebo after an initial titration period where patients received tapentadol ER 100–250mg twice daily for 3 weeks; the primary endpoint was mean change in average pain intensity from the beginning of the double-blind period to week 12. For the tapentadol ER group, mean change in pain intensity was 0.28; for the placebo group, mean change was 1.30. Researchers conclude that tapentadol ER at a dose of 100–250mg twice daily is an effective treatment for managing DPN patients with moderate to severe chronic pain.

Tapentadol ER Effective for Chronic Pain in DPN

OBJECTIVE: This study evaluated the efficacy and tolerability of tapentadol extended release (ER) for the management of chronic pain associated with diabetic peripheral neuropathy (DPN). RESEARCH DESIGN AND METHODS: Adults with moderate to severe DPN pain were titrated to tapentadol ER 100-250 mg ...