Fuzzy score is really an awesome implementation to calculate combined scoring for drug molecules. If possible, please share any publication reference with implementation. I am just curious , is this method same as multi-parameter optimization as mentioned in several places.

the fuzzy score is meant to combine multiple parameters into one numerical value describing a kind of summary fitness. Therefore it can be used as good basis for a multi-parameter optimization strategy. Fuzzy scores are state-of-the-art. Optibrium, a company that specializes in these matters, uses a similar approach. An alternative approach would be a Pareto-ranking, where you identify those molecules from a larger set, where no other molecule exists that have at least one better property without any property being worse.