Abstract:
The present study was designed to evaluate the potential
of five extract and three fractions of Ficus deltoidea to enhance
basal and insulin-stimulated glucose uptake into Chang liver cell line.
The results showed that all Ficus deltoidea extracts and fractions
except petroleum ether extract have the ability to enhance either basal
or insulin-stimulated glucose uptake into liver cell line. Ethanolic and
methanolic extracts as well as acidified chloroform and bacified chloroform
fractions possess insulin-mimetic activity. Of all extracts and fractions,
ethanolic extract possess the highest insulin-mimetic activity. Methanolic
extract and n-butanolic fraction possess insulin-sensitizing activity,
with the highest activity shown by methanolic extract. There is no synergistic
effect between Ficus deltoidea extracts or fractions with 100 nM
insulin. It can be suggested that antidiabetic action of Ficus deltoidea
is partly associated with glucose disposal into liver cells.