MARK-AGE biomarkers of ageing.

Bürkle, Alexander and Moreno-Villanueva, María and Bernhard, Jürgen and Blasco, María and Zondag, Gerben and Hoeijmakers, Jan H. J. and Toussaint, Olivier and Grubeck-Loebenstein, Beatrix and Mocchegiani, Eugenio and Collino, Sebastiano and Gonos, Efstathios S. and Sikora, Ewa and Gradinaru, Daniela and Dollé, Martijn and Salmon, Michel and Kristensen, Peter and Griffiths, Helen R. and Libert, Claude and Grune, Tilman and Breusing, Nicolle and Simm, Andreas and Franceschi, Claudio and Capri, Miriam and Talbot, Duncan and Caiafa, Paola and Friguet, Bertrand and Slagboom, P. Eline and Hervonen, Antti and Hurme, Mikko and Aspinall, Richard
(2015)
MARK-AGE biomarkers of ageing.
Mechanisms of ageing and development.

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Abstract

Many candidate biomarkers of human ageing have been proposed in the scientific literature but in all cases their variability in cross-sectional studies is considerable, and therefore no single measurement has proven to serve a useful marker to determine, on its own, biological age. A plausible reason for this is the intrinsic multi-causal and multi-system nature of the ageing process. The recently completed MARK-AGE study was a large-scale integrated project supported by the European Commission. The major aim of this project was to conduct a population study comprising about 3200 subjects in order to identify a set of biomarkers of ageing which, as a combination of parameters with appropriate weighting, would measure biological age better than any marker in isolation.