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Figures

Transverse abdominal MRI scans (L4 vertebral level; fat appears white with T1 weighting) and 1H-MRS soleus muscle spectra from a control subject (A and A′) and a lipodystrophic subject (B and B′). Both subjects have equivalent amounts of central abdominal fat (by DEXA) and TAT (by MRI). There is less subcutaneous abdominal fat and more visceral abdominal fat in the lipodystrophic subject (B) compared with the control subject (A). Muscle lipid partitioning also differs substantially with increased IMCH2 and reduced EMCH2 in the lipodystrophic subject (B′) compared with the control subject (A′). (Chemical shift indicated in parts per million.) Cn, carnitine; Cr, creatine.

Relationships between IMCL and insulin-stimulated glucose disposal (A) and between IMCL and visceral fat (B) in lipodystrophic subjects (▪) and control subjects (○). Simple regression coefficients (r) and the relevant P values are presented for analyses with both groups combined as there was no difference in relationships between the two groups as assessed by ANCOVA.