If the filing person has previously filed a statement on Schedule 13G to report the acquisition that is the subject of this Schedule 13D, and is filing this schedule because of ss.240.13d-1(e), 240.13d-1(f) or 240.13d-1(g), check the following box [_].

_______________

*

The remainder of this cover page shall be filled out for a reporting person's initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter disclosures provided in a prior cover page.

CUSIP No

31447P100

1.

NAME OF REPORTING PERSONS

I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

Manchester Management PR, LLC

2.

CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS)

(a) [_]

(b) [X]

3.

SEC USE ONLY

4.

SOURCE OF FUNDS

AF

5.

CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e)

This Schedule 13D is an initial filing with
respect to Manchester Management PR, LLC.

Item 1.

Security and Issuer.

The name of the issuer is Fennec Pharmaceuticals Inc. (formerly known as Adherex Technologies Inc.), a Canadian corporation (the "Issuer"). The address of the Issuer's principal executive offices is P.O. Box 13628, 68 TW Alexander Drive, Research Triangle Park, North Carolina 27709. This Schedule 13D relates to the Issuer's Common Stock, no par value (the "Shares").

Manchester Management provides investment management services to private individuals and institutions, including Manchester Explorer and JEB Partners. Manchester Company is the general partner of Manchester Explorer and JEB Partners. Mr. Besser serves as the Managing Member of Manchester Management. Mr. Besser and Donald Besser serve as the Managing Members of Manchester Company. Mr. Frank serves as a portfolio manager and a consultant of Manchester Company.

(d)

None of the Reporting Persons have, during the last five years, been convicted in a criminal proceeding (excluding traffic violations or similar misdemeanors).

(e)

None of the Reporting Persons have, during the last five years, been a party to a civil proceeding of a judicial or administrative body of competent jurisdiction and as a result of such proceeding was or is subject to a judgment, decree or final order enjoining future violations of, or prohibiting or mandating activities subject to, federal or state securities laws or finding any violation with respect to such laws.

Item 3.

Source and Amount of Funds or Other Consideration.

The funds for the purchase of the 1,666,666
Shares beneficially owned by Manchester Management and Manchester Company came from the working capital of Manchester Explorer
and JEB Partners. No borrowed funds were used to purchase the Shares, other than any borrowed funds used for working capital purposes
in the ordinary course of business.

The funds for the purchase of the 1,250,000
Shares directly owned by Manchester Explorer came from the working capital of Manchester Explorer. The net investment costs (including
commissions, if any) of the Shares directly owned by Manchester Explorer is approximately $750,000. No borrowed funds were used
to purchase the Shares, other than any borrowed funds used for working capital purposes in the ordinary course of business.

The funds for the purchase of the 416,666 Shares
directly owned by JEB Partners came from the working capital of JEB Partners. The net investment costs (including commissions,
if any) of the Shares directly owned by JEB Partners is approximately $250,000. No borrowed funds were used to purchase the Shares,
other than any borrowed funds used for working capital purposes in the ordinary course of business.

The funds for the purchase of the 166,666 Shares
directly owned by Mr. Besser came from Mr. Besser's personal funds. The net investment costs (including commissions, if any) of
the Shares directly owned by Mr. Besser is approximately $100,000. No borrowed funds were used to purchase the Shares.

The funds for the purchase of the
166,666 Shares directly owned by Mr. Frank came from Mr. Frank's personal funds. The net investment costs (including commissions,
if any) of the Shares directly owned by Mr. Frank is approximately $100,000. No borrowed funds were used to purchase the Shares.

Item 4.

Purpose of Transaction.

The Reporting Persons are filing this Schedule
13D/A to report a change in their beneficial ownership percentage of the Shares, as indicated in Item 5 below.

Except as otherwise set forth herein,
the Reporting Persons do not have any present plans or proposals which would relate to, or result in, the matters set forth in
subparagraphs (a) – (j) of Item 4 of Schedule 13D. However, subject to market conditions and in compliance with applicable
securities laws, the Reporting Persons reserve the right, at a later date, to effect one or more of such changes or transactions
in the number of Shares they may be deemed to beneficially own in open-market transactions or privately negotiated transactions.
The Reporting Persons may also communicate with the Issuer’s management, the Board and other holders of Shares from time
to time.

Item 5.

Interest in Securities of the Issuer.

(a) - (e)

As of the date hereof, Manchester Management
and Manchester Company may be deemed to be the beneficial owner of 1,666,666 Shares (including warrants), constituting 8.7% of
the Shares, based on 19,109,036 Shares outstanding (assuming closing of the public offering, as reported in the Issuer’s
prospectus supplement filed with the Securities and Exchange Commission pursuant to Rule 424(b) of the Securities Act of 1933,
as amended, on December 11, 2017) as adjusted for warrants beneficially owned by Manchester Management. Manchester Management and
Manchester Company has the sole power to vote or direct the vote of 0 Shares and the shared power to vote or direct the vote of
1,666,666 Shares. Manchester Management and Manchester Company has the sole power to dispose or direct the disposition of 0 Shares
and the shared power to dispose or direct the disposition of 1,666,666 Shares.

As of the date hereof, Manchester Explorer
may be deemed to be the beneficial owner of 1,250,000 Shares (including warrants), constituting 6.6% of the Shares, based on 18,900,703
Shares outstanding (assuming closing of the public offering, as reported in the Issuer’s prospectus supplement filed with
the Securities and Exchange Commission pursuant to Rule 424(b) of the Securities Act of 1933, as amended, on December 11, 2017)
as adjusted for warrants beneficially owned by Manchester Explorer. Manchester Explorer has the sole power to vote or direct the
vote of 0 Shares and the shared power to vote or direct the vote of 1,250,000 Shares. Manchester Explorer has the sole power to
dispose or direct the disposition of 0 Shares and the shared power to dispose or direct the disposition of 1,250,000 Shares.

As of the date hereof, JEB Partners may be
deemed to be the beneficial owner of 416,666 Shares (including warrants), constituting 2.3% of the Shares, based on 18,484,036
Shares outstanding (assuming closing of the public offering, as reported in the Issuer’s prospectus supplement filed with
the Securities and Exchange Commission pursuant to Rule 424(b) of the Securities Act of 1933, as amended, on December 11, 2017)
as adjusted for warrants beneficially owned by JEB Partners. JEB Partners has the sole power to vote or direct the vote of 0 Shares
and the shared power to vote or direct the vote of 416,666 Shares. JEB Partners has the sole power to dispose or direct the disposition
of 0 Shares and the shared power to dispose or direct the disposition of 416,666 Shares.

As of the date hereof, Mr. Besser may be deemed
to be the beneficial owner of 1,833,332 Shares (including warrants), constituting 9.6% of the Shares, based on 19,192,369 Shares
outstanding (assuming closing of the public offering, as reported in the Issuer’s prospectus supplement filed with the Securities
and Exchange Commission pursuant to Rule 424(b) of the Securities Act of 1933, as amended, on December 11, 2017) as adjusted for
warrants beneficially owned by Mr. Besser. Mr. Besser has the sole power to vote or direct the vote of 166,666 Shares and the shared
power to vote or direct the vote of 1,666,666 Shares. Mr. Besser has the sole power to dispose or direct the disposition of 166,666
Shares and the shared power to dispose or direct the disposition of 1,666,666 Shares.

As of the date hereof, Mr. Frank may be deemed
to be the beneficial owner of 1,833,332 Shares (including warrants), constituting 9.6% of the Shares, based on 19,192,369 Shares
outstanding (assuming closing of the public offering, as reported in the Issuer’s prospectus supplement filed with the Securities
and Exchange Commission pursuant to Rule 424(b) of the Securities Act of 1933, as amended, on December 11, 2017) as adjusted for
warrants beneficially owned by Mr. Frank. Mr. Frank has the sole power to vote or direct the vote of 166,666 Shares and the shared
power to vote or direct the vote of 1,666,666 Shares. Mr. Frank has the sole power to dispose or direct the disposition of 166,666
Shares and the shared power to dispose or direct the disposition of 1,666,666 Shares.

The transactions by the Reporting Persons in
the securities of the Issuer since the last Schedule 13D filing filed on November 26, 2013 are set forth in Exhibit B.

Item 6.

Contracts, Arrangements, Understandings or Relationships with Respect to Securities of the Issuer.

The Reporting Persons do not have any contract, arrangement, understanding or relationship with any person with respect to securities of the Issuer.

Item 7.

Material to be Filed as Exhibits.

Exhibit A: Joint Filing Agreement

Exhibit B: Schedule of Transactions in Shares

SIGNATURE

After reasonable inquiry and to the best of
my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

March 29, 2018

(Date)

Manchester Management PR, LLC

By: /s/
James E. Besser

Name: James E. Besser

Title: Managing Member

Manchester Management Company, LLC

By: /s/ James E. Besser

Name: James E. Besser

Title: Managing Member

Manchester Explorer, L.P.

By: /s/ James E. Besser

Name: James E. Besser

Title: Managing Member of the General Partner

JEB Partners, L.P.

By: /s/ James E. Besser

Name: James E. Besser

Title: Managing Member of the General Partner

James E. Besser

/s/ James E. Besser

Morgan C. Frank

/s/ Morgan C. Frank

* Each of the Reporting Persons disclaims beneficial
ownership of the reported securities except to the extent of their pecuniary interest therein.