Behavioral slowing is one of the cardinal features of human aging, contributing to debilitating deterioration in posture, balance and motor functions. This program project analyzes changes in the brain underlying behavioral slowing and tests therapeutic approaches for intervention. Key studies in the program project include assessing the ability of a human growth factor, glial cell line-derived neurotrophic factor (GDNF), to improve or reverse age-associated changes in brain aging.

Behavioral slowing is one of the cardinal features of human aging, contributing to debilitating deterioration in posture, balance and motor functions. This program project analyzes changes in the brain underlying behavioral slowing and tests therapeutic approaches for intervention. Key studies in the program project include assessing the ability of a human growth factor, glial cell line-derived neurotrophic factor (GDNF), to improve or reverse age-associated changes in brain aging.