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A race of giants that were enslaved by the Church of the Deep, these mighty creatures now guard their darkest secrets from intruders. Most of them are several stories tall but the ones guarding the path to Anor Londo are significantly shorter, although still tower over the player. They are usually found sleeping peacefully but will retaliate with crushing blows when disturbed. All giants, barring the smaller variants, do not respawn.

The first giant is found sleeping in the main hall of the cathedral. When approached, he will wake up and attack. He can be killed either on the second floor, where he is first encountered, or at ground level.

The second giant is also in the main hall, although opposite to the other giant. He dwells sleeping in a pool of sludge infested with Writhing Rotten Flesh and can only be attacked from ground level.

A single, but much more resilient, slave dwells sleeping in the central chamber of the second building. He can be attacked either from the second floor or at ground level. Many Hound Rats spawn around him, although not infinitely.

Whilst sleeping, Giant Slaves take very little damage, so it is recommended to wake them up if the player wishes to fight them. Their attacks are very slow but deal tremendous damage and even the aftershock can cause injury. The easiest way to slay them is to wear them down with ranged weapons from under cover, although they will need to be aggroed to prevent them losing interest and falling asleep. This method can be used to defeat the first Giant Slave in the Cathedral of the Deep and the one in the basement of Irithyll Dungeon.

The two giants in the Cathedral reside in a pool of sludge that heavily restricts movement. If the player wishes to fight them conventionally, then they should stay behind the giant and attack its feet, this will avoid their arm swipes but they should still be mindful of their stomps. If engaging them at a distance, they can throw sludge at the player, so they should stay mobile.

The smaller giants in Irithyll are much weaker than the other versions and have a moveset very similar to the Giants of Dark Souls. They are most vulnerable after performing their frenzy combo, although it is recommended to eliminate the Deacons patrolling the area before engaging them, as they will periodically cast fireball spells which do a surprising amount of damage.