Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )

Length:

118

Sequences:

557

Seq/Len:

4.72

HH_delta:

0.905 (20Jul13)

GREMLIN Results:
Residue pairs sorted by strength in covariance:Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

i

j

Raw Score

Scaled Score

61_G

83_D

0.47163

3.882

18_E

40_E

0.34852

2.869

60_I

84_V

0.26997

2.222

62_K

82_E

0.26523

2.183

36_L

39_L

0.23757

1.956

34_V

65_I

0.22202

1.828

56_K

89_K

0.22198

1.827

69_W

72_L

0.20141

1.658

69_W

77_V

0.20037

1.649

78_V

86_L

0.19784

1.629

19_N

24_Q

0.16966

1.397

71_S

75_K

0.15501

1.276

54_E

89_K

0.15452

1.272

6_S

10_N

0.15179

1.250

18_E

44_D

0.14961

1.232

5_V

27_V

0.1489

1.226

18_E

42_K

0.14888

1.226

52_P

58_G

0.14774

1.216

20_L

32_G

0.14576

1.200

54_E

57_S

0.14268

1.175

10_N

24_Q

0.14218

1.170

35_E

62_K

0.13776

1.134

72_L

77_V

0.13667

1.125

40_E

48_N

0.13604

1.120

35_E

64_R

0.13486

1.110

13_L

24_Q

0.13196

1.086

20_L

23_D

0.13042

1.074

53_I

88_L

0.12751

1.050

30_W

77_V

0.12697

1.045

74_S

95_E

0.12683

1.044

74_S

93_Q

0.12669

1.043

24_Q

29_L

0.12664

1.043

60_I

89_K

0.12644

1.041

45_A

88_L

0.12605

1.038

41_L

60_I

0.12579

1.036

24_Q

28_S

0.12545

1.033

8_L

12_Y

0.12487

1.028

28_S

31_N

0.12457

1.025

9_L

25_L

0.12407

1.021

2_E

30_W

0.12397

1.021

3_S

18_E

0.12391

1.020

5_V

13_L

0.12158

1.001

26_S

94_D

0.12136

0.999

5_V

79_I

0.12008

0.988

13_L

36_L

0.11984

0.987

75_K

78_V

0.11863

0.977

29_L

34_V

0.11861

0.976

30_W

69_W

0.11837

0.974

16_Y

30_W

0.1181

0.972

13_L

16_Y

0.1177

0.969

51_L

76_P

0.11675

0.961

14_G

25_L

0.11635

0.958

30_W

33_E

0.11585

0.954

67_I

92_D

0.11569

0.952

33_E

54_E

0.11558

0.951

37_R

62_K

0.1142

0.940

61_G

90_P

0.11388

0.937

14_G

21_D

0.11385

0.937

27_V

31_N

0.11353

0.935

31_N

75_K

0.11338

0.933

15_R

92_D

0.11309

0.931

21_D

63_L

0.11283

0.929

17_I

39_L

0.11003

0.906

6_S

46_L

0.10992

0.905

79_I

89_K

0.10963

0.902

33_E

66_K

0.10958

0.902

63_L

74_S

0.10938

0.900

46_L

55_V

0.10898

0.897

61_G

82_E

0.10838

0.892

50_G

91_K

0.10835

0.892

2_E

20_L

0.10803

0.889

42_K

47_N

0.10794

0.889

16_Y

41_L

0.1073

0.883

4_L

8_L

0.1069

0.880

38_N

60_I

0.10608

0.873

49_L

81_I

0.10594

0.872

15_R

48_N

0.10585

0.871

14_G

17_I

0.10568

0.870

42_K

58_G

0.10557

0.869

28_S

84_V

0.10552

0.869

9_L

13_L

0.10523

0.866

2_E

61_G

0.10498

0.864

19_N

76_P

0.10489

0.863

16_Y

34_V

0.10454

0.861

7_S

27_V

0.10423

0.858

5_V

56_K

0.10373

0.854

55_V

88_L

0.1032

0.850

17_I

41_L

0.1031

0.849

7_S

18_E

0.10304

0.848

25_L

29_L

0.10231

0.842

17_I

75_K

0.10221

0.841

19_N

43_K

0.10165

0.837

8_L

47_N

0.10115

0.833

52_P

76_P

0.10108

0.832

2_E

5_V

0.10096

0.831

43_K

81_I

0.10048

0.827

68_P

87_V

0.09987

0.822

2_E

9_L

0.09885

0.814

28_S

90_P

0.09852

0.811

66_K

78_V

0.09812

0.808

67_I

71_S

0.0981

0.808

2_E

24_Q

0.09807

0.807

5_V

8_L

0.09797

0.806

17_I

29_L

0.0978

0.805

86_L

89_K

0.09763

0.804

48_N

91_K

0.09731

0.801

56_K

95_E

0.09706

0.799

41_L

88_L

0.09684

0.797

38_N

61_G

0.09677

0.797

20_L

90_P

0.09655

0.795

44_D

63_L

0.09655

0.795

75_K

91_K

0.09641

0.794

35_E

78_V

0.09631

0.793

26_S

35_E

0.09614

0.791

16_Y

28_S

0.09602

0.790

5_V

30_W

0.09471

0.780

4_L

10_N

0.09378

0.772

48_N

63_L

0.09357

0.770

15_R

71_S

0.09304

0.766

32_G

69_W

0.09284

0.764

31_N

59_S

0.09279

0.764

57_S

81_I

0.09277

0.764

16_Y

49_L

0.09272

0.763

21_D

53_I

0.09264

0.763

65_I

90_P

0.09247

0.761

51_L

81_I

0.09236

0.760

11_K

28_S

0.09221

0.759

91_K

94_D

0.092

0.757

36_L

76_P

0.09197

0.757

32_G

53_I

0.09159

0.754

64_R

80_E

0.09152

0.753

19_N

49_L

0.09126

0.751

2_E

26_S

0.09084

0.748

28_S

79_I

0.08993

0.740

14_G

31_N

0.08988

0.740

25_L

58_G

0.08984

0.740

21_D

30_W

0.08957

0.737

19_N

25_L

0.08954

0.737

43_K

73_W

0.08939

0.736

55_V

66_K

0.08932

0.735

30_W

70_T

0.08899

0.733

Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.

HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits: Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)