Dr. Paul Clapham is collaborating with Dr. David Russell (Cornell, Ithaca) to investigate the effect of HIV infection on the antibacterial properties of the macrophage. Contact: Paul.clapham@umassmed.edu

2.HIV/TB Researchers:

Hardy Kornfeld: Antimycobacterial Mechanisms of Apoptosis in the Lung, Impact of Diabetes and Hyperlipidemia on Host Defense, Heterologous Immunity between Viruses and Mycobacteria hardy.kornfeld@umassmed.edu

The Virology Core facility functions as a resource for Virus, Cells, and Molecular Virology Assays. It will provide Phenotyping service, Screening service and Qualitative/Quantitative Detection service to the participating CFAR investigators. The facility will have standardized and centralized routine research techniques and reagents available for the investigators.

BSL3 flow cytometer. The BSL3 FACS Aria is configured with 5 parameters on the 488nm laser, 3 parameters on the 633nm laser, 3 parameters on the 405nm laser, and 3 parameters on the 350nm laser. This machine is housed in a BSL3 facility allowing sorting unscreened human and/or infectious samples up to biosafety level 3.

Humanized mouse models. Dr. Robert Woodland has generated human/mouse chimeras in which the development of the human lymphocyte compartment is promoted by the addition of species-restricted cytokines. This mouse model is currently in use to test HIV vaccine candidates and may be useful as a coninfection model.