The four first-round quarterbacks in the 2012 NFL draft class—Andrew Luck (Indianapolis Colts), Robert Griffin III (Washington Redskins), Ryan Tannehill (Miami Dolphins) and Brandon Weeden (Cleveland Browns)—are about to take their talents to their first NFL training camps.

The rookies have a long road ahead of them as they try to put their arm, athleticism, accuracy and other individual attributes together in a successful package. But in the short term, whose development will benefit most from his supporting cast? When comparing him to the others, Luck isn't as fortunate with surrounding factors for his inaugural season:

Best coaching: Griffin/Redskins. Coach Mike Shanahan has a great track record when it comes to turning mobile quarterbacks into efficient passers. Having won two Super Bowls with Hall of Famer John Elway—an idol of Griffin's—Shanahan already has won over his latest prized pupil. Griffin is smart enough to quickly pick up the nuances of Shanahan's spin on the rhythmic West Coast offense, and he'll be in position to get the ball out quickly and accurately.

Best receiving corps: Griffin/Redskins. Pierre Garcon was signed away from Luck's Colts and joins fellow speedy wideout Santana Moss in Washington. Both are known for their burst after the catch, giving Griffin a chance to make big plays on both intermediate and deep routes. With Garcon and Moss stretching the field, Griffin will benefit from tight end Fred Davis' fine pass-catching skills on shorter routes. In addition, second-year running back Roy Helu already has proved to be an effective receiver.

Best go-to option: Luck/Colts. Griffin, Tannehill and Weeden don’t have a receiver with the credentials of Reggie Wayne. The same could be said for many of the veteran QBs in the league. While Wayne works to develop a rapport with Luck after years of being Peyton Manning's favorite target, another pass catcher will be a big help. The Colts' decision to draft Coby Fleener—Luck's tight end at Stanford—will ease the transition. Fleener, as a fellow rookie also trying to grasp NFL offense, may be more of a security blanket than a playmaker early. But there's no doubt having a college teammate to target will add greatly to Luck's comfort level.

Best running game: Weeden/Browns. While the Redskins and Colts sort out their backfield mixes, there's no doubt who will be carrying a full load for the Browns. And with all due respect to the erstwhile Heisman winner who will flank Tannehill in the Miami Dolphins’ backfield, Reggie Bush isn't quite the all-around back Trent Richardson is.

The Browns have been able to patch together above-average rushing attacks with Peyton Hillis and Chris Ogbonnaya the past two seasons. Richardson brings a much better combination of power and explosiveness and will take the burden of headlining Cleveland's offense away from Weeden. Weeden's strong, accurate arm will be in the best position to exploit matchups downfield thanks to the attention Richardson will draw upfield.

Best offensive line: Weeden/Browns. Joe Thomas gets the edge over Miami's Jake Long as the best left tackle—and therefore top blindside pass protector—who will stand in front of a rookie quarterback in '12. The Browns also have one of the game's best young centers, Alex Mack, to snap to Weeden.

The Colts' line woes were exposed without Manning in '12, and Luck will endure some of the same problems. The Redskins will be happy for how well Griffin can move as they iron out injury issues up front.

Most favorable division: Luck/Colts. In the NFC East, Griffin not only must duel Eli Manning, Tony Romo and Michael Vick, but he also faces improved defenses of the Giants, Cowboys and Eagles. Matt Schaub and the Texans' 3-4 defense present a pair of challenges in the AFC South, but overall Luck has it better than the rest. Consider that the Tennessee Titans (Jake Locker) and Jacksonville Jaguars (Blaine Gabbert) may end up starting second-year first-rounders who aren't as polished as Luck.

Least favorable division: Weeden/Browns. Every other team in the AFC North—Pittsburgh, Baltimore and Cincinnati—made the playoffs last season. Those teams also happened to rank No. 1, No. 3 and No. 7, respectively, in total defense. Weeden's game of catchup with Ben Roethlisberger, Joe Flacco and Andy Dalton will have a most difficult start.

Most familiarity: Tannehill/Dolphins. It's pretty rare for a rookie to reunite with his college mentor immediately in the NFL. Before drafting Tannehill, the Dolphins hired his former Texas A&M coach—Mike Sherman—as offensive coordinator. While Tannehill is stuck in a battle with veterans Matt Moore and David Garrard just to get on the field in '12, his connection with Sherman is his sole edge in experience.

Least pressure: Tannehill/Dolphins. He is likely to sit behind Garrard or Moore for a long stretch, and there are no expectations for Miami to do anything big in a division with reigning AFC champion New England. There's already sky-high hype surrounding Griffin in Washington, and Luck is following a legend in Indianapolis. Weeden easily comes in second here.

Most pressure: Luck/Colts. The Colts decided to reboot their franchise, and Luck has the unenviable task of replacing Peyton Manning as the face of it. Several other familiar veterans, such as Dallas Clark and Joseph Addai, are gone, and they have a new head coach (Chuck Pagano) installing a new defense (3-4). As much pressure as Griffin faces, anything he does will be better than what the Redskins have gotten from their quarterback in a while.

Luck has been tabbed as a can't-miss prospect for a few years, and as the first overall pick, he is expected to deliver. Given Luck’s rookie situation, however, Colts fans need to be patient because the results—like with Manning before him—may not be seen until his second full season.

Most likely to succeed as a rookie: Griffin. While he settles in as a passer, there will be plenty of flash. If the Redskins let him loose to let the ball fly, he’ll reward them with plenty of highlight-reel throws. He will have his fair share of mistakes, of course, but the added dimension of his dynamic running ability will add up to the most memorable first season of this skilled quarterback quartet.