This paper discusses the interoperability of e-business processes by using an ontology approach with description logic and agent systems to achieve e-business automation. An innovative e-business process modeling framework is proposed that outlines the building blocks required for Internet-based e-business in order to enable e-business process automation. The framework helps in understanding the role of many proposed standards with respect to the building blocks and in identifying both overlaps and gaps among them. The domain knowledge of e-business processes is conceptualised as an e-business process ontology that enables agents’ communication in e-business application sharing and reusing. Several agent-based automation mechanisms are discussed based on the ontology that provides implementation guidelines to e-business process automation.