STRING allows inspection of the interaction evidence for any given network. Choose any of the viewers above (disabled if not applicable in your network).

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:query proteins and first shell of interactors

white nodes:second shell of interactors

Node Content

empty nodes:proteins of unknown 3D structure

filled nodes:some 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

Slin_1368

Lipid A biosynthesis acyltransferase (290 aa)

Predicted Functional Partners:

Slin_5831

3-deoxy-D-manno-octulosonic-acid transferase (416 aa)

0.987

Slin_5962

KpsF/GutQ family protein (322 aa)

0.877

Slin_3449

lipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (377 aa)

0.873

Slin_6494

3-hydroxyacyl-ACP dehydratase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis (464 aa)

0.870

lpxD

UDP-3-O-(3-hydroxymyristoyl) glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (342 aa)

0.867

lpxK

Tetraacyldisaccharide 4’-kinase; Transfers the gamma-phosphate of ATP to the 4’-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4’-bis-phosphate (lipid IVA) (355 aa)

acyl-ACP--UDP-N- acetylglucosamine O-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (265 aa)

a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1

node2

node1 accession

node2 accession

node1 annotation

node2 annotation

score

Slin_1368

Slin_1369

Slin_1368

Slin_1369

Lipid A biosynthesis acyltransferase

WbqC-like family protein

0.646

Slin_1368

Slin_2802

Slin_1368

Slin_2802

Lipid A biosynthesis acyltransferase

2-dehydro-3-deoxyphosphooctonate aldolase

0.763

Slin_1368

Slin_3449

Slin_1368

Slin_3449

Lipid A biosynthesis acyltransferase

lipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

0.873

Slin_1368

Slin_5831

Slin_1368

Slin_5831

Lipid A biosynthesis acyltransferase

3-deoxy-D-manno-octulosonic-acid transferase

0.987

Slin_1368

Slin_5962

Slin_1368

Slin_5962

Lipid A biosynthesis acyltransferase

KpsF/GutQ family protein

0.877

Slin_1368

Slin_6494

Slin_1368

Slin_6494

Lipid A biosynthesis acyltransferase

3-hydroxyacyl-ACP dehydratase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis

0.870

Slin_1368

Slin_6495

Slin_1368

Slin_6495

Lipid A biosynthesis acyltransferase

acyl-ACP--UDP-N- acetylglucosamine O-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

UDP-3-O-(3-hydroxymyristoyl) glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

0.867

Slin_1368

lpxK

Slin_1368

Slin_2019

Lipid A biosynthesis acyltransferase

Tetraacyldisaccharide 4’-kinase; Transfers the gamma-phosphate of ATP to the 4’-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4’-bis-phosphate (lipid IVA)

0.858

Slin_1369

Slin_1368

Slin_1369

Slin_1368

WbqC-like family protein

Lipid A biosynthesis acyltransferase

0.646

Slin_2802

Slin_1368

Slin_2802

Slin_1368

2-dehydro-3-deoxyphosphooctonate aldolase

Lipid A biosynthesis acyltransferase

0.763

Slin_2802

Slin_3449

Slin_2802

Slin_3449

2-dehydro-3-deoxyphosphooctonate aldolase

lipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

0.906

Slin_2802

Slin_5831

Slin_2802

Slin_5831

2-dehydro-3-deoxyphosphooctonate aldolase

3-deoxy-D-manno-octulosonic-acid transferase

0.907

Slin_2802

Slin_5962

Slin_2802

Slin_5962

2-dehydro-3-deoxyphosphooctonate aldolase

KpsF/GutQ family protein

0.993

Slin_2802

Slin_6494

Slin_2802

Slin_6494

2-dehydro-3-deoxyphosphooctonate aldolase

3-hydroxyacyl-ACP dehydratase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis

0.790

Slin_2802

Slin_6495

Slin_2802

Slin_6495

2-dehydro-3-deoxyphosphooctonate aldolase

acyl-ACP--UDP-N- acetylglucosamine O-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

UDP-3-O-(3-hydroxymyristoyl) glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

0.906

Slin_2802

lpxK

Slin_2802

Slin_2019

2-dehydro-3-deoxyphosphooctonate aldolase

Tetraacyldisaccharide 4’-kinase; Transfers the gamma-phosphate of ATP to the 4’-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4’-bis-phosphate (lipid IVA)

0.879

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Network Stats

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Functional enrichments in your networkNote: some enrichments may be expected here (why?)

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Statistical background

For the above enrichment analysis, the following statistical background is assumed: