Experimental evidence indicates that the kinin peptide binds to bradykinin B2 receptor (B2R) to trigger various beneficial effects on the cardiovascular system. However, the effects and underlying mechanisms of B2R in cardiac aging remain unknown. A significant age-dependent decrease in B2R expression in the myocardium was observed in C57BL/6J mice. ...

Cardiovascular disease is the most prevalent and influential comorbidity affecting outcomes in geriatric surgical patients. The unique physiology of the aging cardiovascular system and the impact of these changes during the stress of surgery is presented in this article. The necessary response to these changes is discussed with attention to ...

While males and females are equally at risk of sudden cardiac arrest (SCA), females are less likely to be resuscitated. Cardiopulmonary Resuscitation (CPR) may be inhibited by socio-cultural norms about exposing female victims' chests. Empirically confirming this hypothesis is limited by lack of patient simulators modeling realistic female physiques. A ...

Whether internalizing symptoms increase or remain at similar levels throughout childhood is currently not well understood. Moreover, the association between vagal regulation of cardiac activity and internalizing symptoms across childhood needs to be clarified. We used a multilevel conceptual framework to examine how children's vagal regulation of cardiac activity and ...

Aminoguanidine (AG), a well known inhibitor of advanced glycation end products, has been reported to attenuate cardiac hypertrophy and fibrosis. However, the underlying mechanism by which AG exerts its anti-fibrotic activity is not well understood. Reactive oxygen species (ROS) and matrix metalloproteinases (MMPs) are implicated as playing a major role ...

Escobales Nelson N Department of Physiology, School of Medicine, University of Puerto Rico, San Juan, Puerto - - 2014

Mitochondria-generated reactive oxygen species (ROS) play a crucial role in the pathogenesis of aging and age-associated diseases. In this study, we evaluated the effects of XJB-5-131 (XJB), a mitochondria-targeted ROS and electron scavenger, on cardiac resistance to ischemia-reperfusion (IR)-induced oxidative stress in aged rats. Male adult (5-month old, n=17) and ...

Cardiac tissue from female rainbow trout demonstrates a sex-specific preference for exogenous glucose and glycolysis, impaired Ca(2+) handling, and a greater tolerance for hypoxia and reoxygenation than males. We tested the hypothesis that dichloroacetate (DCA), an activator of pyruvate dehydrogenase (PDH), will enhance cardiac energy metabolism and Ca(2+)-handling in female ...

Regular assessment of psycho-physiological parameters in aged subjects helps to clarify physical and mental conditions which are important in the prevention of health-endangering events to assure a healthy aging. Thirty older care female residents consented voluntarily to participate in the study. The somatic and psycho-physiological parameters recorded were handgrip force, ...

Kapidžić Ana A Institute of Biophysics, Faculty of Medicine, University of Belgrade, Belgrade, - - 2014

We examined the effects of gender and age in young and middle-aged subjects on the level of cardio-respiratory interaction by analyzing properties of cardiac, respiratory and cardiac-respiratory regulatory mechanisms under paced breathing. In 56 healthy subjects, ECG (RR interval) and respiratory signal were simultaneously acquired in supine position at paced ...

Periostin, as an extracellular matrix (ECM) proterin, plays a critical role in myocardial fibrosis and also might be involved in the heart inflammatory process since it is a downstream molecule of IL4 and IL13. Considering the possible important role of periostin in heart aging, this study explored periostin expression pattern ...

To demonstrated the combined effects of aging and carcinogen treatment on cancer stem/stem-like cells (CSCs) of gastric mucosa in an animal model. In this study we investigated the effects of aging and Helicobacter pylori (H. pylori) inflammation as a model for inflammation induced carcinogenesis in human and rat gastric mucosa ...

This study measured and analyzed the position and dimension of genial tubercle (GT) and mental foramen (MF) STUDY DESIGN: Retrospective chart review study. Tertiary care teaching hospital. Two hundred ten subjects were included who received 3-dimensional (3D) facial computed tomography (CT), and the GT and MF were evaluated. Subjects were ...

Objective. To investigate copeptin as a biomarker for small-for-gestational-age. Methods. We conducted a nested case-control study on maternal copeptin levels measured in gestational week 12 and 19 and risk of small-for-gestational age. Cases were defined as pregnant women who delivered a small-for-gestational-age infant. Small-for-gestational age was defined as a birth ...

Tadjibaev Pulod P Department of Family Medicine, The North-Western State Medical University named after I.I. Mechnikov, St. Petersburg, Russian - - 2014

This study aims to determine the cardiac dysfunction prevalence, to investigate the relationship between the Short Physical Performance Battery (SPPB) test and structural and functional echocardiographic parameters and to determine whether SPPB scores and cardiac dysfunction are independent mortality predictors in an elderly Russian population. A random sample of 284 ...

The life cycle and occurrence of Haemaphysalis concinna were investigated under field conditions from April 2012 to March 2013 in Eerguna National Natural Reserve Area situated on the China-Russia border in Inner Mongolia, China. Under natural conditions, the whole life cycle of H. concinna was allowed to complete in a ...

Abstract We assessed the impact of land use, demographic factors, and season on the prevalence and intensity of Baylisascaris procyonis infections in raccoons (Procyon lotor) in Ontario, Canada. From March to October, 2012, we recorded the number of B. procyonis individuals in the intestinal tracts of raccoons submitted to the ...

Bio-load and bio-profile of Mycobacterium avium subspecies paratuberculosis was studied in the domestic livestock population of the country. Of the 23 429 farm and farmer's animals screened, average bio-load was 23.3% (Period of study; 28 years for goats; 13 years for sheep, cattle and buffaloes). Species-wise, bio-load was 20.1, 32.7, 39.3 and 28.3% in goats, sheep, cattle and buffaloes, respectively. Bio-load was ...

The aim of the study was to investigate the influence of radiotherapy on IL-2 and IL-6 secretions of mucous epithelial cells of small intestine and the inhibition effect of deproteinized calf blood extractive (DCBE, also known as Actovegin in trade name) on apoptosis of mucous epithelial cells of small intestine. ...

Objective:Mother's own milk and donor human milk use is increasing as a means of necrotizing enterocolitis (NEC) prevention. Early onset of enteral feeding has been associated with improvement of many outcomes but has not been shown to reduce the incidence of NEC. Better definition of the window of risk for ...

Irregularities in cardiac repolarization are known to predispose for arrhythmias and sudden cardiac death in humans. The QT interval is a quantitative measurement of repolarization, and clinically, the QTc (QT interval corrected for heart rate) and Tpeak to Tend intervals (TpTe) are used as repolarization markers. To support the use ...

Plasma variables may be affected by breed or body weight (BW). Small-sized dogs are very common, but no specific reference intervals (RI) are used. The primary objective of this prospective study was to assess the potential effect of breed, BW, age, and sex on routine plasma analytes and packed cell ...

Campylobacter jejuni is usually recovered from chickens in commercial broiler farms after 2 to 3 weeks of age. This study was conducted to clarify whether fecal excretion is associated with the age of exposure to this bacterium. Day-of-hatch broiler chickens were separated from a flock in a local commercial farm, ...

Microbial contact begins prior to birth and continues rapidly thereafter. Few long term follow-up studies have been reported and we therefore characterized the development of intestinal microbiota of ten subjects from the 2(nd) week of life to 13 years of age. PCR-denaturing gradient gel electrophoresis combined with several bacterial group ...

Abstract Macuahuitloides inexpectans n. gen., n. sp., (Molineidae: Anoplostrongylinae) is herein described. The description is based on specimens removed from the small intestine of ghost-faced bats, Mormoops megallophylla, from central Mexico. The monotypic genus is unique in featuring sexual dimorphism on the cuticular ornamentation, which consists on the presence of ...

The aim was to analyze the socio-environmental variables associated with malnutrition and intestinal parasitoses in children from Aristóbulo del Valle, Province of Misiones (Argentina). A cross-sectional study was performed in 2,291 schoolchildren (age, 4-14 years). Body weight and height were measured and body mass index was calculated. NHANES III reference ...

Forty wild canids including 31 golden jackals (Canis aureus Linné, 1758) and 9 red foxes (Vulpes vulpes Linné, 1758) collected between 2008 and 2011 in the northeast, northwest and center of Tunisia were necropsied and examined for intestinal helminth parasites. All jackals and foxes were found infected with a prevalence ...

The aim of this study was to analyze the association of intestinal parasitic diseases with age and gender in patients with diarrhea attending a rural hospital in southern Ethiopia in the period 2007-2012. A total of 32,191 stool examination was performed in patients who presented with diarrhea. The overall prevalence ...

A gradual shift of colorectal adenoma and carcinoma location toward the proximal colon has been recently observed both in the United States and Europe. We aimed to study the polyp and adenoma detection rate in a major endoscopy center of northwestern Romania over a 16-year period, and to characterize the ...

The esophageal submucosal glands (SMG) protect the squamous epithelium from insults such as gastroesophageal reflux disease by secreting mucins and bicarbonate. We have observed metaplastic changes within the SMG acini that we have termed oncocytic glandular metaplasia (OGM), and necrotizing sialometaplasia-like change (NSMLC). The aim of this study is to ...

Ageing of the population is an imminent global problem. Lactobacillus casei Zhang (LcZ) was isolated from Inner Mongolian fermented milk, koumiss. LcZ possesses numerous probiotic properties in in vitro tests and in animal models. However, it has never been tested in any human trial. In the current study, the impact ...

To Evaluate the length of small bowel (SB) in Thai patients. The present prospective study included Thai adults who underwent elective open laparotomy at the Department of Surgery, Faculty of Medicine Siriraj Hospital between August 2011 and May 2012. Patients who had previous laparotomy, intra-abdominal adhesions, or gross abnormality of ...

Abstract Epidemiological studies indicate that certain aspects of lifestyle and genetics act as risk factors for a variety of cardiovascular disorders, including coronary disease, hypertension, heart failure and stroke. Aging, however, appears to be the major contributor for morbidity and mortality of the impaired cardiovascular system. Growth hormone (GH) and ...

Management of irritable bowel syndrome (IBS) imposes a heavy economic burden. This study was to estimate the epidemio-logic features of IBS and to report the IBS burden for the first time in the Korean population. A cross-sectional study was conducted using the National Health Insurance (NHI) system database, which covers ...

This review updates the current views on aging gastric mucosa and the mechanisms of its increased susceptibility to injury. Experimental and clinical studies indicate that gastric mucosa of aging individuals-"aging gastropathy"-has prominent structural and functional abnormalities vs young gastric mucosa. Some of these abnormalities include a partial atrophy of gastric ...

The Operative Link for Gastritis Assessment (OLGA) and the Operative Link on Gastric Intestinal Metaplasia Assessment (OLGIM) staging systems have been suggested to provide risk assessment for gastric cancer. This study aimed to evaluate the distribution of OLGA and OLGIM staging by age and Helicobacter pylori status. We studied 632 ...

As the "baby boomers" age, the percentage of the population over sixty-five years of age is increasing rapidly. Chronic disease management is an important component in the care of the elderly. The effects of aging on different organ systems are also pertinent; such as the weakening homeostatic response to injury ...

The palatal masticatory mucosa is widely used as donor material for periodontal plastic surgery. The thickness of graft tissue is important for graft survival. We investigated the thickness of palatal mucosa using a bone sounding technique. We also examined the relation of age and gender to the thickness of palatal ...

We investigated the reproductive biology of Knodus moenkhausii, an abundant small-sized characin fish with broad occurrence in the Paraná River basin, Brazil. Specimens were collected monthly to determine fecundity, length at first maturity, reproductive period and spawning type. Gonads were macroscopically classified according to their form, size and texture in ...

MicroRNA (miR)-320a, miR-145, and miR-192 have been shown to play a role in colorectal carcinogenesis and metastasis. We examined if there is a difference in expression during the histologic progression from normal mucosa (NM) to high-grade dysplastic adenomas (HG). Genome-wide miRNA expression profiling was performed on 113 colon adenomas. Information ...

Methane which can sometimes be found in exhaled breath of humans is known to reflect in situ intestinal methanogenic activity. In recent years, several factors have been studied in order to understand their relevance to methane production in the intestinal tract. However, the relationship between age and methane producing status ...

Perinatal mortality is high among small-for-gestational age (SGA) piglets and continues to be an economic burden and threat to animal welfare. As the physiological role of serotonin (5-hydroxytryptamine, 5-HT) in perinatal development and gastrointestinal function in the pig remains unknown, the aim of this study was to assess the enteric ...

In primate populations, endoparasite species richness and prevalence are associated with host traits such as reproductive and social status, age, sex, host population density, and environmental factors such as humidity. We analyzed the species richness and prevalence of intestinal parasites in two sympatric primate populations, one of Alouatta palliata and one of ...

Aim: Atrophic gastritis (AG), first step in the cascade leading to gastric adenocarcinoma, is related to Helicobacter pylori (H. pylori) infection. Currently, the gold standard for the diagnosis of AG is esophagogastroduodenoscopy (EGD) with histological examination of the biopsy specimens. However, since the latter are taken in random order and ...