Majel and Gene had been lovers for years when he decided it was time to marry her and asked her to join him -- although he happened to be visiting Japan at the time. Gene did not adhere to any particular religion and since they were in Japan they chose to have a Shinto-Buddhist wedding on 6 August 1969. They regarded this as their real wedding, but his divorce was not yet final and they made it legal with a civil ceremony on 29 December 1969.

Is one of only 32 actors or actresses to have starred in both the original "Star Trek" (1966) (up to and including Star Trek VI: The Undiscovered Country (1991)) and then in one of the spin-offs.

She is the only actor to appear in all five live-action "Star Trek" series ("Star Trek" (1966), "Star Trek: The Next Generation" (1987), "Star Trek: Deep Space Nine" (1993), "Star Trek: Voyager" (1995) and "Enterprise" (2001)). In addition to this, she supplied various voices in "Star Trek" (1973).

Shortly before her death, she completed voiceover work as the voice of the Enterprise's main computer for J.J. Abrams's upcoming Star Trek (2009).

In addition to her voiceover work, she also provided the voice of automated railroad-defect detectors for the Union Pacific and other railroads. Her voice can be heard on railroad radio channels throughout the nation.