Abstract

The proteins of flotillin-1 and flotillin-2 were originally discovered in axon regeneration
of goldfish retinal ganglion cells. They are generally used as marker proteins of
lipid rafts and considered to be scaffolding proteins of lipid microdomains. Although
they are ubiquitously expressed and well-conserved from fly to man, their exact functions
remain controversial. In this review, we summarize the structure of flotillins and
some functions of them, such as regulating axon regeneration, endocytosis, T cell
activation, insulin signaling, membrane protein recruitment, roles in the progression
of some diseases and so on.