start-ver=1.4
cd-journal=joma
no-vol=101
cd-vols=
no-issue=7-8
article-no=
start-page=699
end-page=709
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1989
dt-pub=19890831
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Effects of enflurane anesthesia on circulation dynamics and blood catecholamine concentration
kn-title=エンフルレン麻酔の循環動態と血中カテコラミン濃度に関する実験的研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Effects of enflurane anesthesia were studied on the circulation dynamics and blood catecholamine (CA) concentrations during and after inhalation 2% or 3% enflurane in oxygen in 8 dogs at each concentration. During inhalation, the mean arterial pressure (MAP) and cardiac index (CI) decreased significantly. After stopping inhalation, the MAP recovered rapidly to the control values, but the CI recovered to only 65% of the control values. Immediately after starting inhalation, blood CA concentrations decreased significantly in both groups. After stopping inhalation, blood adrenaline (AD) concentration increased rapidly to 6 and 5 times as the control values in the 2% and 3% groups, respectively. Blood noradrenaline (NA) concentration increased to 3 times as the control values in both groups. One hundred and twenty min after starting inhalation, the dogs did not respond to painful stimulation even in the 2% group. In this study, it has been suggested that the circulation dynamics are suppresed when enflurane has reached more than 0.5 minimum alveolar concentration (MAC) and that the centripetal impulse is thoroughly blocked and CA secretion from the adrenal grand is inhabited at 0.7 MAC of enflurane.
en-copyright=
kn-copyright=
en-aut-name=KajikiHideki
en-aut-sei=Kajiki
en-aut-mei=Hideki
kn-aut-name=梶木秀樹
kn-aut-sei=梶木
kn-aut-mei=秀樹
aut-affil-num=1
ORCID=
affil-num=1
en-affil=
kn-affil=岡山大学医学部麻酔・蘇生学教室
en-keyword=血中エンフルレン濃度
kn-keyword=血中エンフルレン濃度
en-keyword=血中アドレナリン濃度
kn-keyword=血中アドレナリン濃度
en-keyword=血中ノルアドレナリン濃度
kn-keyword=血中ノルアドレナリン濃度
en-keyword=循環動態
kn-keyword=循環動態
END