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School of Pharmacy

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Core Facilities

The research laboratories and core facilities (10,200 sq.ft) are located on the 2nd floor of 9501 Jeronimo Road in Irvine. The facilities include space for dedicated tissue culture, NMR, autoclave, and procedure and environmental rooms.

A 4,000 sq. ft. vivarium is planned for the first floor of the 9401 building. A second Core Lab Facility was completed in August 2015. Formal courses for students on laboratory instrumentation and techniques will be taught by the Core Facility Manager. Both basic and advanced analytical instrumentation required for biomedical, pharmaceutical, and biotechnological research are available for shared usage. Facility services are available to private companies on a fee-for-service basis.

The UHPLC is an analytical instrument used to identify and characterize the compounds in a mixture under a very high pressure (19,000 psi.) and to provide fast and higher resolution. Different detectors were included in the upgrade.

The Nikon Ti-E is a fully motorized for automated multi-mode image techniques and acquisition. The Ti offers improved system speed, increased flexibility and efficient multi-mode microscopy as part of a fully-integrated microscope system that is ideal for high-end research and live cell imaging.

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Spectrofluorophotometers

RF-5301PC SpectrofluorophotometerCompared to absorbance methods, fluorescence sensitivity is tens to thousands times better - this means that you can analyze nanogram to picogram samples with great results. Fluorescence can be used also to identify a specific molecule in a complex background. When the compound of interest does not exhibit natural fluorescence, functional group-specific probes may be used to label the compound.

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Spectrometers

ALPHA FT-IR Spectrometer/Platinum ATR

Bruker Alpha FTIR interferometer with platinum ATR is based on Bruker Optics` patented RockSolid™ design. It offers full FT-IR sampling flexibility. ALPHA's Platinum ATR single reflection diamond ATR module is easy to use for routine analysis. A variety of sampling options for temperature controlled measurements and liquid flow through analysis complete the versatility of the Platinum ATR.

Shimadzu BioSpec-nano is a micro-volume UV/VIS spectrophotometer. It offers superior detection limits, making it the perfect instrument for quantitation of DNA, RNA, protein analysis, and photometric measurements. Quantitation can be rapidly and simply carried out with very small samples ranging from 1µL-2µL And, with dedicated functions, such as automated sample mounting and wiping.

Shimadzu UV-2600 is a compact universal, research-grade UV/VIS spectrophotometer that can be used in a wide range of fields, and easily expanded to suit the measurement objective. By using the optional integrating sphere, the measurement wavelength range of the UV-2600 can be extended to the near-infrared region of 1400 nm.

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Mass Spectrometers

Autoflex Speed MALDI-TOF Mass Spectrometer

Bruker Autoflex Speed MALDI-TOF and TOF/TOF technology is easy-to-use; robust systems for both traditional MALDI applications (reliable and detailed protein/peptide characterization, and polymer analysis) as well as cutting edge work (high resolution MALDI Tissue Imaging, glycan analysis. Further improved smartbeam™-II laser technology with up to 2,000 Hz repetition rate is a must for MALDI Tissue Imaging and delivers superior performance for any Proteomics project.

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X-ray Crystallography

Bruker D8 Venture Gallium Liquid Metal Jet Single Crystal Diffraction

The METALJET for X-ray diffraction delivers the smallest and most intensive X-ray beam of any home lab X-ray source to meet the ever increasing demands of modern structural biology including protein crystallography and Small Angle X-ray Scattering.