The Marvel sequel took $26.6 million to cross the $200 million mark in the US alone, while world-wide it has now raked in $586.6 million.

Depp’s big-budget sci-fic epic, however, could only muster $11.5 million, marking the actor’s third box office disappointment in a row after The Lone Ranger and Dark Shadows. Transcendence even came in lower than The Tourist, which debuted to $16.5 million in 2010.

The film’s distributors will, however, look to overseas markets, where Depp’s more recent films have fared better of late. In China, for instance, Transcendence opened to a solid $11.4 million, for an international total so far of $17.4 million.

Transcendence opened in fourth spot in the US, beaten by holdover animation Rio 2 which grossed $22.5, and new Christian film Heaven Is For Real, which took a mighty $21.5 million despite its low budget.

That movie is based on the real-life story of Nebraska pastor Todd Burpo, whose young son said he found himself in heaven during emergency surgery. The film is adapted from the pastor’s book of the same name, co-written by Lynn Vincent.

Rounding out the top five, was another new opening, the comedy horror sequel A Haunted House 2.