Use of PET and fMRI to demonstrate the differential pattern of dopaminergic activity, dopamine receptor binding in the putamen and caudate and correlation these findings to MADRS in MDD subjects treated with escitalopram and aripiprazole.

Correlation of D2binding before and after adjunctive aripiprazole with emergence of extrapyramidal symptoms and akathisia.

55

All

18 Years to 55 Years (Adult)

NCT00953745

2009-0419

May 2009

February 2012

February 2012

August 6, 2009

August 10, 2011

Washington University in St. Louis, School of MedicineSt. Louis, Missouri, United States