EXACT Sciences (EXAS)

Extensions to other cancers.DNA Integrity Assay, or DIA®, is an epigenetic marker for the presence
of cancer, as indicated by longer, less degraded strands of DNA. The presence
of these longer strands of DNA is believed to be associated with escape from
apoptosis (natural cell death), which itself is a hallmark of cancer. We have
validated the DIA theory through collaboration with a bioinformatics company
using a virtual model of cancer. In addition, several independent papers have
been published that support our observations around DIA. We believe our
proprietary DIA may potentially be applicable to the detection of other cancers
in addition to colorectal cancer.