Introduction: The study aimed to examine the effect of effectiveness of cognitive behavioral therapy on mental health in Multiple Sclerosis patients.

Material and Methods: The statistical society was all the patients with MS in Hamedan city. In a semi experimental design and using convenience sampling, 30 participants were selected among those patients and they were divided in two groups of intervention and control by random. The former and latter clusters were trained in between the one and one and half an hour of 6 sessions while the control group had no therapeutic training. The therapeutic clusters were assessed with of Lovibond depression, anxiety; stress (DASS, 1995) were completed at three stages; prior to, four weeks later and two months after the intervening sessions. Data were subjected to descriptive statistics and the analysis with a mixed ANOVA design.

Results: The results of this study showed that there were significant differences between test and control groups after intervention (p<0.001).

Conclusion: According to the results above, we can say, in the area of treatment and working with Multiple Sclerosis Patens cognitive therapy group according to its nature, seems to be very efficient and promising.