Please note you can't delete a profile if you are currently logged on as
that user, an area that the profile is in use will be displayed.

If you want to remotely delete a locally stored profile you can use the
DELPROF.EXE utility which is supplied with the Windows NT Server Resource
Kit. The tool deletes all profiles that have not been used for a given
number of days, for example

C:\>delprof /p /q /i /c:\\garfield /d:3

Would delete any profiles that have not been used for 3 days. The /p
prompts for confirmation before deleting each profile, the /q suppresses
the starting:

Delete profiles on \\garfield that have not been used in the last 1
days? (Yes /No)

prompt. The /i ignores errors, /c is the computer name and /d: is the
number of days the profile needs to be older than.