Cholangiocarcinoma

Cholangiocarcinoma is the most common tumor of bile duct. Cholangiocarcinoma may involve the bile duct at liver hilum, lower CBD or intrahepaticbiliary system. Hilar is the most common type of cholnagiocarcinoma

Rick factors are

Choledochal cyst

Clonorchis sinensis

Hepaticolithiasis

Primary sclerosingcholangitis

Biliary-enteric drainage procedures

Symptoms

Painless jaundice

Itching

Weight loss and anorexia

Fever and pain abdomen in the case of cholangitis

Diagnosis

Diagnosis is suspected when USG/CT/MRCP reveals obstruction of biliary system, and a mass around the CBD

For tissue diagnosis, EUS – FNA, ERCP-brushings, and spyglass with biopsy are available options

Treatment

Surgery is the best option for resectable tumors

For unresectablehilarcholangiocarcinoma, chemo-radiotherapy followed by liver transplantation is the new treatment strategy.

For advanced tumors, ERCP and stenting can be done for palliation of jaundice/itching and fever