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They are a humanoid species with large amounts of yellow to reddish-brown spotting on their heads, arms and bodies. They have pale skin and a plume of ginger hair across the top of their heads. Adult males also have ginger whiskers growing on either side of their face, which, when tugged induce sexual arousal.

By the 2340s, the Talaxians were involved in a lengthy war with the Haakonian Order. The war was so costly to both sides that many Talaxians fled to other regions of the Delta Quadrant, one group even managed to settle on an asteroid on the Delta/Beta Quadrant border by 2377. The war between the Talaxians and the Haakonian's ended in 2355 when the Metreon Cascade weapon was deployed on the Talaxian moon of Rinax, killing millions instantly. As a result the Talaxians declared an unconditional surrender. (VOYepisodes: "Jetrel", "Homestead")