The active ingredient triclosan helps prevent gingivitis; it is effective in preventing bacterial infections. However, according to the Mayo Clinic, there are studies indicating triclosan as hazardous to human health. This ingredient can have the potential to alter hormone regulation, contribute to the growth of antibiotic resistant germs and can harm the immune system.

Colgate-Palmolive halted the use of triclosan in their antibacterial dish liquid and hand soap, but still continue to use this ingredient in all their toothpaste, as of 2015. Sodium laurel sulfate is a chemical of concern with multiple studies indicating it as a potential hormone disrupter, organ system toxin and an irritant, among other concerns listed by the Environmental Working Group and Dr. Joseph Mercola.