The investigators found that younger men with an MMSE score of 29 had a lower risk for 3-year progression to AD dementia compared with older women with a 24 MMSE score (26% [95% CI, 19%-34%] vs 76% [95% CI, 65%-84%], respectively).

The average follow-up in this study was 2.4 years, which may be too short to provide insight into longer-term progression to disease risks in this cohort. In addition, the investigators note that the generalizability of the findings remains a current challenge.

Despite these limitations, the prognostic models used in this study “show how biomarker research can be translated into clinical practice in a tractable manner” and may “help determine AD dementia and any type of dementia in patients with mild cognitive impairment at the individual level.”