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Game over: White Sox 6, Red Sox 4: The Red Sox' five-game winning streak came to an end. Red Sox starter Jon Lester lost for the first time this season, allowing all six runs (five earned) over six innings. Adam Dunn blasted a three-run homer in the first inning to pace the White Sox attack. Jarroid Saltalamacchia belted his fifth homer, had two hits and nearly tied the game when his drive to center was caught near the wall by Alex Rios.

Mike Napoli singled to open the ninth inning off White Sox closer Addison Reed, but the Red Sox were unable to sustain a rally. Middlebrooks hit long drive to the 400 foot market in center, but it was caught.Paul Konerko made a great diving stab of Stephen Drew's hard grounder and throw to the pitcher covering to end the game. Reed earned his 15th save. The game was played in 2:52 before 21,816 at US Cellular Field.

Bottom 8th: White Sox 6, Red Sox 4 - White Sox threaten but do not score off Craig Breslow. Viciedo walked and Keppinger doubled, but Breslow got the next two batters to escape.

Injury update: Shane Victorino left the game with tightness in his left hamstring.

Top 8th: White Sox 6, Red Sox 4 - Shane Victorino walked with one out and Pedroia did his best to avoid a double-play when he beat the relay to first on his ground ball to second base. Ortiz popped out.

Top 7th: White Sox 6, Red Sox 4 - Will Middlebrooks knocked in a pair with a double to left field after Ortiz and Napoli drew walks. Line on Lester: 6 IP, 7 H, 6 R, 5 ER, 3 BB, 2 K. He threw 109 pitches.

Bottom 6th: White Sox 6, Red Sox 2 - Jon Lester retired the side.

Top 6th: White Sox 6, Red Sox 2 - Jarrod Saltalamacchia singled to lead off the inning, but Jacoby Wllsbury knocked into a double play. After Shane Victorino reached an infield hit to the pitcher, Dustin Pedroia flew out to end the ining.

Bottom 5th: White Sox 6, Red Sox 2 - Ramirez reached on an error by Will Middlebrooks, stole second. Alex Rios walked, but Konerko knocked into a double play. After Dunn walked, with runners now at the corners, Viciedo got the count to 3-2, before shooting a single up the middle to score the sixth White Sox run.

Top 4th: White Sox 5, Red Sox 2 - Dustin Pedroia reached on an infield hit to third base, but was doubled up on David Ortiz' GIDP. Mike Napoli, who entered the game hitting .214 with 19 strikeouts in 56 career at-bats at US Cellurlar, struck out.

Bottom 3rd: White Sox 5, Red Sox 2 - Lester allowed a single to Viciedo with two outs, but rebounded to get Jeff Keppinger to ground out for the third out.

Bottom 2nd: White Sox 5, Red Sox 0 - Jon Lester often talks about there are those five or starts when you have nothing. This might be one of them. Three straight doubles by Tyler Greene, Alejandro De Aza and Alexei Ramirez produce two runs,

Top 2nd: White Sox 3, Red Sox 0 - The first six Red Sox hitters have been retired by Dylan Axelrod.

Bottom 1st: White Sox 3, Red Sox 0 - Rough start for Jon Lester who gave up a three-run homer to Adam Dunn on a 2-0 pitch with Alex Rios and Paul Konerko aboard after he'd retired the first two White Sox batters.

Top 1st: Red Sox 0, White Sox 0 - The Red Sox couldn't muster a lot against Dylan Axelrod as he got outs with ground balls from Jacoby Ellsbiry and Shane Victorino and a fly ball out to right by Dustin Pedroia.