A theoretical framework is proposed to explain how chronic circadian misalignment (CCM) may contribute to adverse birth outcomes. CCM refers to abnormal neuroendocrine activity resulting from chronic sleep disruption. Peripheral circadian clocks exist in reproductive and immune tissues and coordinate ovulation, implantation, and pregnancy maintenance. Peripheral circadian clocks are controlled by the master circadian pacemaker in the hypothalamus. Research indicates shift work may lead to CCM thereby influencing pregnancy outcomes.

Methods:

A narrative review identified relationships between circadian rhythms, shiftwork, and birth outcomes. Findings were compared, themes synthesized, and limitations reviewed. The Bollinger sleep- immune model was used in conjunction with the reproductive circadian literature to explore associations between sleep, immunity, and reproduction.

Results:

Narrative review identified knowledge deficits and advances in the study of CCM in relation to birth outcomes. Altered sleep and abnormal exposure to light were found to affect synchronization of the master circadian pacemaker with peripheral sites. From this, CCM may develop and contribute to immune dysregulation and reproductive consequences including altered fertility, menstrual irregularities, and decreased term pregnancy.

Conclusions: This theory provides a framework for how inflammation may develop from CCM and influence birth outcomes. Further clarification of theoretical linkage between CCM and reproductive outcomes will shed light on how the environment impacts health, fertility, and reproduction.

42nd Biennial Convention 2013 Theme: Give Back to Move Forward. Held at the JW Marriott

Note:

This is an abstract-only submission. If the author has submitted a full-text item based on this abstract, you may find it by browsing the Virginia Henderson Global Nursing e-Repository by author. If author contact information is available in this abstract, please feel free to contact him or her with your queries regarding this submission.

Full metadata record

DC Field

Value

Language

dc.language.iso

en_US

en_GB

dc.type.category

Abstract

en_GB

dc.type

Presentation

en_GB

dc.title

The Biological Implications of Chronic Circadian Misalignment in Pregnancy: Is there a Link to Poor Birth Outcomes?

<p>Poster presented on: Saturday, November 16, 2013, Sunday, November 17, 2013</p><b>Purpose </b><p>A theoretical framework is proposed to explain how chronic circadian misalignment (CCM) may contribute to adverse birth outcomes. CCM refers to abnormal neuroendocrine activity resulting from chronic sleep disruption. Peripheral circadian clocks exist in reproductive and immune tissues and coordinate ovulation, implantation, and pregnancy maintenance. Peripheral circadian clocks are controlled by the master circadian pacemaker in the hypothalamus. Research indicates shift work may lead to CCM thereby influencing pregnancy outcomes. <p><b>Methods: </b><p>A narrative review identified relationships between circadian rhythms, shiftwork, and birth outcomes. Findings were compared, themes synthesized, and limitations reviewed. The Bollinger sleep- immune model was used in conjunction with the reproductive circadian literature to explore associations between sleep, immunity, and reproduction. <p><b>Results: </b><p>Narrative review identified knowledge deficits and advances in the study of CCM in relation to birth outcomes. Altered sleep and abnormal exposure to light were found to affect synchronization of the master circadian pacemaker with peripheral sites. From this, CCM may develop and contribute to immune dysregulation and reproductive consequences including altered fertility, menstrual irregularities, and decreased term pregnancy. <p><b>Conclusions</b>: This theory provides a framework for how inflammation may develop from CCM and influence birth outcomes. Further clarification of theoretical linkage between CCM and reproductive outcomes will shed light on how the environment impacts health, fertility, and reproduction.

en_GB

dc.subject

preterm labor

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dc.subject

shiftwork

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dc.subject

circadian clock

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dc.date.available

2013-12-19T17:30:32Z

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dc.date.issued

2013-12-19

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dc.date.accessioned

2013-12-19T17:30:32Z

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dc.conference.date

2013

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dc.conference.name

42nd Biennial Convention

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dc.conference.host

Sigma Theta Tau International, the Honor Society of Nursing

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dc.conference.location

Indianapolis, Indiana, USA

en_GB

dc.description

42nd Biennial Convention 2013 Theme: Give Back to Move Forward. Held at the JW Marriott

en_GB

dc.description.note

This is an abstract-only submission. If the author has submitted a full-text item based on this abstract, you may find it by browsing the Virginia Henderson Global Nursing e-Repository by author. If author contact information is available in this abstract, please feel free to contact him or her with your queries regarding this submission.

en_GB

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