"Recorded potentials in the extracellular space (ECS) of the brain is a
standard measure of population activity in neural
tissue. Computational models that simulate the relationship between
the ECS potential and its underlying neurophysiological processes are
commonly used in the interpretation of such measurements. Standard
methods, such as volume-conductor theory and current-source density
theory, assume that diffusion has a negligible effect on the ECS
potential, at least in the range of frequencies picked up by most
recording systems. This assumption remains to be verified. We here
present a hybrid simulation framework that accounts for diffusive
effects on the ECS potential. ..."
Reference: 1 .
Halnes G, Mäki-Marttunen T, Keller D, Pettersen KH, Andreassen OA, Einevoll GT (2016) Effect of Ionic Diffusion on Extracellular Potentials in Neural Tissue. PLoS Comput Biol12:e1005193 [PubMed]

Model Information (Click on a link to find other models with that property)