For the first time, the 2018 NCAA Division I Baseball Tournament seeded the top 16 teams, rather than only the top 8 teams as had been the practice since 1999. This ensures that the regional featuring the top-seeded team is paired with the regional hosted by the 16th-seeded team, where in the past Super Regionals were paired generally along geographical lines.[10]

^The Big East awards a Coaching Staff of the Year award instead of a Coach of the Year award. It goes to the team instead of an individual, although the head coach is cited by name in the award announcement.

^The Big West styles its Player of the Year award as "Field Player of the Year".

^The Horizon League is the only Division I conference that presents separate season-ending awards for starting and relief pitchers. The award for starters is styled as the "Pitcher of the Year" award.

Hill resigned from Alabama A&M on June 25 after 5 seasons for the head coaching job at Martin Methodist College of the NAIA.[62] Pitching coach and recruiting coordinator Lora was promoted to head coach of the Bulldogs on August 23.[63]

Durkac was fired on May 29 after 4 seasons at Illinois State, finishing 82-134 overall and 27-55 in conference play.[68] On June 22, the Redbirds hired Purdue pitching coach Holm for the head coaching job.[69]

Brad Hill Announced that on May 8 after fifteen seasons that he will step down affective at the end of the season. He became the team's all time most successful coach and won the 2013 Big 12 Conference title and hosted a super regional that year. On June 8, the Wildcats hired former Boston College, Virginia Tech, and Oklahoma head coach Pete Hughes.[73]

Cannizaro resigned on February 22, only three games into the Bulldogs' season, after he was found to be involved in an extramarital affair with a woman working in MSU's athletic department. Former Kentucky head coach and current MSU pitching coach Henderson was named as interim replacement.[76] MSU announced the hiring of Indiana head coach Chris Lemonis on June 26.[70]

Murray State announced on May 25 that Moulder would not return next season, ending his 4-year tenure at the school.[77] On July 2, the school hired former Racer assistant coach Skirka to be the new head coach.[78]

Casey announced his retirement on September 6 after 24 seasons at Oregon State and 30 seasons overall, winning 900 games with the Beavers and 3 NCAA championships. Associate head coach Bailey will serve as the interim head coach of the team for the 2019 season.[79]

Graham, who was the oldest head coach in Division I baseball at age 82, announced on April 25 that his contract was not being renewed and that the 2018 season would be the last of his 27-year head coaching tenure at Rice.[81] The Owls hired Tennessee Tech head coach Bragga after the season.[82]

Mike Gillespie announced his retirement from the UC Irvine baseball team after eleven seasons with the school his successor Ben Orloff was named his replacement beginning in the 2019 season. He became the most successful coach in College baseball history with 1108 wins.[84]