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When the young Iris Murdoch meets fellow student John Bayley at Somerville College, Oxford, he is a naive virgin easily flummoxed by her libertine spirit, arch personality, and obvious artistic talent. Decades later, little has changed and the couple keeps house, with John doting on his more famous wife. When Iris begins experiencing forgetfulness and dementia, however, the devoted John struggles with hopelessness and frustration, and becomes her caretaker, as his wife's mind deteriorates from the ravages of Alzheimer's disease.