The NFL entered its second week on Sunday and it was all about settling scores on the gridiron. In the heavily anticipated divisional grudge-match, the Seahawks’ running back Marshawn Lynch led his team with three touchdowns in a devastating rout over Seattle’s fiercest rival, the San Francisco 49ers, in front of a record-setting crowd at Century Link Field on Sunday night. The 2012 NFC Champions never quite gained their footing offensively as the Seahawks held the 49ers to only one field goal depiste their explosive debut against the Packers last week.

Earlier in the day, Peyton Manning maintained his perfect record against his younger sibling Eli with a 41-23 win in East Rutherford. Peyton’s Broncos chalked up an easy victory over Eli’s Giants, after the younger Manning threw four interceptions in New York’s second straight loss this season. This is the third time the brothers have met on the field, with all three victories going to the elder.

In Green Bay on Sunday, Aaron Rodgers rallied the Packers in a record setting win after last week’s disappointing season opener. Rodgers threw a career high 480 yards, while James Stark added 132 yards on the ground in a 38-20 win over the struggling Washington Redskins.

In Buffalo, rookie EJ Manuel sealed a victory for the Bills after connecting with wide receiver Stevie Johnson with six seconds left on the clock, while in Chicago Jay Culter also took to the air during the final ticks of the game to lead the Bears in their second-straight comeback win of the season.

Correction: A previous version of this story referred to Buffalo’s rookie quarterback as EJ Sanders, instead of the correct name, EJ Manuel.