Shut Up, Lady

From Homestar Runner Wiki

After a voiceover comment by a soft-voiced woman, Strong Bad will sometimes exclaim, "Shut up, lady!" Her most common comment is "that looks sinful", referring to food or food-like substances that seem bad for your health.

Email dictionary — An off-screen woman comments on a dictionary covered in butterscotch sauce. In this instance, Strong Bad says "Shut up, Shut Up Lady", possibly addressing the character as the "Shut Up Lady".

@StrongBadActual — Strong Bad has twice responded to a comment with "Shut up, lady!". The first time was when a user named @Paunchberry posted a picture of a dessert, commenting that "that looks sinful". The second time was when a user named @CamTroid replied to a Tweet with the Shut Up Lady's line from licensed.