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Glyco-oxidative stress modulates diabetes severity

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"Diabetes is at epidemic proportions in Native American communities, and to a lesser extent in the general population. Understanding the role of environmental stressors on disease outcome holds the promise of improving patient management and potentially identifying new treatment targets.” - Serrine Lau

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Relevance to SWEHSC:

Diabetes is at epidemic proportions in Native American communities, and to a lesser extent in the general population. Understanding the role of environmental stressors on disease outcome holds the promise of improving patient management and potentially identifying new treatment targets.

Drs. Lau and Stump have collected blood and urine samples from >100 subjects, predominantly of Hispanic ethnicity. Quantification of free MG and MG-adducts in urine is in progress.

MS-based proteomics approaches to differentially profile and quantitate serum protein modification by MG in normal subjects and T2D patients, revealed several novel potential biomarkers. One of these, MG-modified fibrinogen is now being validated. This biomarker appears to offer superior discrimination of diabetic complications than conventional biomarkers that capture glucose binding only as glycated hemoglobin (HbA1C)

Urinary arsenic metabolites (As)/24 hrs were also measured (Gandolfi, RFG1) in 14 subjects without diabetes and 19 subjects with diabetes. Total urinary As was significantly elevated in diabetes (p

The Southwest Environmental Health Sciences Center (P30 ES006694) is a Unit of the Center for Toxicology, at the College of Pharmacy, funded by the National Institute of Environmental Health Sciences. We also acknowledge the people – past, present, and future – of the Tohono O'odham Nation, on whose traditional lands we study and work.