Palihapitiya said a lot about Facebook's effect on society during the interview, but here's the money quote:

"The short-term, dopamine-driven feedback loops that we have created are destroying how society works. No civil discourse. No cooperation. Misinformation. Mistruth. And it's not an American problem. This is not about Russian ads. This is a global problem. So we are in a really bad state of affairs right now in my opinion," he said.

Palihapitiya also said that people building Facebook in the early days knew in the back of their minds that the platform could be abused, but ignored their instincts.