really desperate to get nsmb to work :(

please can anyone help.... i have a 4.2e softmod with all the peices from the guide on this site.i have burnt a disk using imgburn and the version of the game is qf-nsmb rar. which is patched. i ran it on neogamma r7 and tried lots of combo's of settings but still cant get past the turn remote,refer to manual section.PLEASE i really am confused about what im doing

dont think its brand new,but i have successfully dl super smash brawl,fifa 10,sqeeballs,ghostbusters and some older titles and they work fine on the neo region settings WII MORE so surely this will.Do i need to change my cios? im on the one the guide said 249