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The Yale PET Center is a “state-of-the-art” research facility complete with lead-lined “hot cells” and manipulator arms used for the synthesis of PET radiopharmaceuticals.

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Yale PET Center radiochemist assembles equipment in a lead-lined “hot cell” for the production of a radiopharmaceutical tracer that will target specific tissues and regions of the body.

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Yale PET Center technologist monitors a research subject who is undergoing whole body scanning. As the subject’s body slides through the HR+ scanner, radioactive signals are detected and converted into three-dimensional images of tissue concentrations.

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Radioactive signals detected by the HRRT brain scanner are converted into three-dimensional images of organ function that are viewed and analyzed by PET researchers.

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Yale PET Center technologist demonstrates safe handling of a radiopharmaceutical used in PET research. To minimize radiation exposure to research staff members, radiopharmaceuticals are transported in lead containers.

Yale Positron Emission Tomography

In 2004, Yale University broke ground for a new, state-of-the-art Positron Emission Tomography (PET) Research Center dedicated to providing the highest quality of nuclear imaging research. Located on Howard Avenue in New Haven, with close proximity to other Yale School of Medicine departments, this impressive 22,000 sq. ft. facility has been established to advance the interests of Yale clinicians, scientists, and students in molecular imaging research.

The PET Center is comprised of a technologically advanced radiochemistry laboratory engaged in the development and use of a rich set of PET radiopharmaceuticals labeled with the most common PET isotopes (11C, 15O, 13N, and 18F); and an imaging and data analysis section that oversees scanning procedures and optimizes data acquisition and analysis. The PET center has grown over time to include approximately 55 clinician scientists, basic scientists, technicians, and students.

PET is a non-invasive diagnostic scanning technique that provides researchers and clinicians with quantitative visual images of organ function. PET scans can detect biochemical changes in body tissues before structural changes occur from disease. This information allows clinicians to be proactive in their treatments and enables researchers to develop early biomarkers of disease that can aid diagnosis and advance drug development.

The Yale University PET Center collaborates with other School of Medicine departments to provide educational opportunities for doctoral and postdoctoral trainees. Collaborations with industry partners serve to advance the use of molecular imaging in new medication discovery and the development of new PET radiopharmaceuticals. Current research interests focus on disorders of the central nervous system (CNS), oncology, cardiology, and diabetes.