α-Synuclein is a major component of Lewy bodies in the affected neurons in Parkinsonís disease. This protein has a mass of 14.5 kDa (140 amino acids long) and consists of a conserved degenerative amino-terminal domain and an acidic carboxyl-terminal with higher sequence divergence. α-Synuclein is predominantly expressed in brain, specifically in cerebellum, thalamus, neocortex, hippocampus, and striatum regions. Other tissues express α-Synuclein at very low levels. The physiological role of α-synuclein is not yet well understood. However, the presence of imperfect KTKEGV lipid interacting repeats suggests that it may be involved in synaptic vesicle homeostasis. AnaSpecís EndoFree α-Synuclein has very low endotoxin content and every lot is checked for fibrillation capability. Related Product:SensoLyteģAnti-alpha-Synuclein (Human, Mouse, Rat) ELISA Kit.