Browse our PDGFRA Proteins (PDGFRA)

On www.antibodies-online.com are 38 Platelet-Derived Growth Factor Receptor, alpha Polypeptide (PDGFRA) Proteins from 11 different suppliers available. Additionally we are shipping PDGFRA Antibodies (576) and PDGFRA Kits (60) and many more products for this protein. A total of 703 PDGFRA products are currently listed.

More Proteins for PDGFRA Interaction Partners

The diabetes-induced increase in PDGFRalpha+ cells may be mediated by FOXO3 up-regulation via the inhibition of the PI3K/Akt signaling pathway in STZ-induced diabetic mice.

Constitutive activation of PDGFRalpha leads to expansion of cartilage underlying the coronal sutures, which contribute to suture closure through endochondral ossification, in a process regulated in part by PI3K/AKT (show AKT1 Proteins) signaling.

Conditional knockout of Pdgfra in Pdgfra-expressing tissues in mouse embryos at different embryonic days (E9.5 and E10.5) resulted in multiple developmental anomalies of the frontonasal region, the cranium and the abdominal wall musculature. Furthermore, the day at which the Pdgfra is deleted influences the repertoire of the anomalies of the conditional knockout embryos.

FOXA3 (show FOXA3 Proteins) is a marker of the Sertoli cell lineage and of the adult Leydig cell population, and is a regulator of Pdgfra transcription in Leydig cells.

PDGFRalpha and PDGFRbeta are coexpressed in the craniofacial mesenchyme of mid-gestation mouse embryos and that ablation of Pdgfrb (show PDGFRB Proteins) in the neural crest lineage results in increased nasal septum width, delayed palatal shelf development, and subepidermal blebbing.

The results from this study indicate that PDGF (show PDGFA Proteins) signaling is required for fiber hypertrophy, extracellular matrix production, and angiogenesis that occur during muscle growth.

transient middle cerebral-arterial occlusion (MCAO) was introduced into the mice with conditional Pdgfrb (show PDGFRB Proteins)-gene inactivation, including N-PRbeta-KO mice where the Pdgfrb (show PDGFRB Proteins)-gene was mostly inactivated in the brain except that in vascular pericytes

PDGFR alpha has an important role in cranial neural crest cell mitosis within the mandibular processes

PDGF (show PDGFA Proteins) signalling in the dermis and in dermal condensates is dispensable for hair follicle induction and formation.

The PDGFRA kinase domain structure we report in this study has potential to facilitate development of new agents which can inhibit this kinase, including both its activating and drug-resistant mutations.

There are two platelet-derived growth factor receptor (PDGFR (show PDGFRB Proteins)) genes (PDGFRA and PDGFRB (show PDGFRB Proteins)), and they reside on chromosome 4 and 5.

PDGFRA Protein Profile

Protein Summary

This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies suggest that this gene plays a role in organ development, wound healing, and tumor progression. Mutations in this gene have been associated with idiopathic hypereosinophilic syndrome, somatic and familial gastrointestinal stromal tumors, and a variety of other cancers.