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Description

Deuterium: Discovery and Applications in Organic Chemistry provides a well-illustrated overview of the discovery of 2H or heavy hydrogen, the stable hydrogen isotope with both a proton and a neutron in its nucleus. The work introduces the isotope, its discovery, physical properties, nomenclature, and common compounds, also exploring its application in organic chemistry through classic and recent examples from literature. Finally, the book devotes one chapter to Deuterium in medicinal chemistry and the biological effects of Deuterium Oxide, better known as D2O.

Key Features

Provides unique coverage not found elsewhere that is presented in an accessible, dedicated short work

Contains practical information and examples on the use of Deuterium (D or 2H, Heavy Hydrogen) in organic synthesis

Presents a detailed description of Deuterium’s discovery and applications in the pharmaceutical industry

Readership

Organic chemistry researchers in general as well as medicinal chemists

Table of Contents

Dedication

Acknowledgments

Introduction

Hydrogen is Ubiquitous

Applications

No Single Book is Found

References

Chapter 1. Isotopes

Abstract

1.1 Definition

1.2 Isotopes of Hydrogen

1.3 Uses of Deuterium in Organic Chemistry

References

Chapter 2. Deuterium

Abstract

2.1 Discovery

2.2 Deuterium Gas (D2)

2.3 Deuterium Oxide (D2O)

References

Chapter 3. Deuterium-Labeled Compounds

Abstract

3.1 Nomenclature

3.2 Synthesis of Organic Compounds

3.3 LiAlD4 and NaBD4

References

Chapter 4. Applications in Organic Chemistry

Abstract

4.1 Background

4.2 Classic Examples

4.3 Recent Examples

References

Chapter 5. Applications in Medicinal Chemistry

Abstract

5.1 Biological Effects of D2O

5.2 Deuterium in Medicinal Chemistry

References

Conclusion

Author Index

Details

About the Author

Jaemoon Yang

Jaemoon Yang is Senior Chemist II at Cambridge Isotope Laboratories, Inc. in Andover, Massachusetts. He received his Ph.D. degree in organic chemistry in 2000 from the University of Pittsburgh under the supervision of Professor Craig Wilcox. He carried out his postdoctoral work with Professor Marisa Kozlowski at the University of Pennsylvania. He joined CIL in 2007 where he is actively involved in the synthesis of deuterium-labeled compounds and the development of better methods for efficient H/D exchange reactions. He has more than 10 publications in peer-reviewed journals from the graduate and postdoctoral research. He is the author of “Six-Membered Transition States in Organic Synthesis” published in 2008.

Affiliations and Expertise

Cambridge Isotope Laboratories, Inc., Andover, Massachusetts, USA

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