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Details for Patent: 5,068,440

Details for Patent: 5,068,440

Title:

Process for the manufacture of N,N-dimethyl-1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride monohydrate

Abstract:

A process for the preparation of N,N-dimethyl-1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride monohydrate, a non-hygroscopic material which can be used as a pharmaceutical in the treatment of depression.

Inventor(s):

Jeffery; James E. (Nottingham, GB2), Whybrow; Derek (Nottingham, GB2)

Assignee:

Boots Company, PLC (Nottingham, GB2)

Filing Date:

Jan 19, 1990

Application Number:

07/467,471

Claims:

1. A process for the preparation of N,N-dimethyl-1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride monohydrate comprising recrystallising N,N-dimethyl-1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride from a medium consisting of or containing water.

2. A process as claimed in claim 1 in which the medium containing water is a mixture of water and a water-immiscible solvent.

3. A process as claimed in claim 2 in which the water-immiscible solvent is toluene, xylene or cyclohexane.

4. A process as claimed in claim 1 in which the solvent containing water is a mixture of water and a water-miscible solvent.

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