"1) After binding to a surface protein and being transported into cholinergic neurons by endocytosis, the light chain of the toxin exhibits protease activity.

(Miochol)"

Cholinergic agonists (quaternary compounds)

IV exhibits mainly muscarinic effects; nicotnic actions are only seen after muscarinic receptors have been blocked by atropine (ie. Increases BP and heart rate by stimulating N1-cholinergic receptors at sympathetic ganglia)

(Provocholine)"

Muscarinic receptor agonist

(Carbamylcholine)"

Nicotinic and muscarinic agonist

(Urecholine)"

Muscarinic agonist with a selective effect on the GI and GU tracts

Succinylcholine

Specificity for N2-cholinergic receptors found at the neuromuscular junction of skeletal muscle; depolarizes the motor endplate of skeletal muscle by mimicing the agonist action of Ach --> flaccid paralysis of skeletal muscle (noncompetitive blockade)

(Pilocar, Isopto Carpine)"

"Tertiary amine

(Evoxac)"

Synthetic muscarinic agonist

Pilocarpine

Treatment of glaucoma

"Increase aqueous outlfow: contraction of the meridional fibers of the ciliary muscle increases the iridiocorneal angle and/or the tone and alignment of the trabeculae allowing aqueous humor to flow more easily into the Canal of Schlemm

"1) After binding to a surface protein and being transported into cholinergic neurons by endocytosis, the light chain of the toxin exhibits protease activity.

(Miochol)"

Cholinergic agonists (quaternary compounds)

IV exhibits mainly muscarinic effects; nicotnic actions are only seen after muscarinic receptors have been blocked by atropine (ie. Increases BP and heart rate by stimulating N1-cholinergic receptors at sympathetic ganglia)

(Provocholine)"

Muscarinic receptor agonist

(Carbamylcholine)"

Nicotinic and muscarinic agonist

(Urecholine)"

Muscarinic agonist with a selective effect on the GI and GU tracts

Succinylcholine

Specificity for N2-cholinergic receptors found at the neuromuscular junction of skeletal muscle; depolarizes the motor endplate of skeletal muscle by mimicing the agonist action of Ach --> flaccid paralysis of skeletal muscle (noncompetitive blockade)

(Pilocar, Isopto Carpine)"

"Tertiary amine

(Evoxac)"

Synthetic muscarinic agonist

Pilocarpine

Treatment of glaucoma

"Increase aqueous outlfow: contraction of the meridional fibers of the ciliary muscle increases the iridiocorneal angle and/or the tone and alignment of the trabeculae allowing aqueous humor to flow more easily into the Canal of Schlemm