Final Report - 3DGENOME (3D Genome structure and function)

Abstract

This is the final report for the 3DGENOME project, whose aim was to analyse the three-dimensional (3D) folding of the chromatin fibre inside the interphase nucleus and unveil the relationship between the now well-established one-dimensional structure of the human genome (i.e. the nucleotide sequence) with its 3D folding inside the nucleus. The report reveals how they have concentrated collective efforts on a limited number of human chromosomes.

Results of these studies have given us new insight in the spatial organisation of the human genome in the cell. Basic principles have been identified, which are independent of cell type and differentiation state and gene expression pattern.