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A ghoul is a monster or evil spirit in Arabic mythology, associated with graveyards and consuming human flesh. The term was first used in English literature in 1786, in William Beckford's novel Vathek, which describes the ghūl of Arabic folklore. In modern fiction, the term has often been used for a certain kind of undead monster. By extension, the word "ghoul" is also used in a derogatory sense to refer to a person who delights in the macabre, or whose profession is linked directly to death, such as a gravedigger or graverobber.

Originating around the eighth century AD, a ghoul is a mythical creature often described as hideous human-like monster that dwelt in the desert or other secluded locations in order to lure travelers astray. It was not until Antoine Galland translated Arabian Nights into French that the western idea of ghoul was introduced. Galland depicted the ghoul as a monstrous creature that dwelled in cemeteries, feasting upon corpses.

Ghouls are human-like creatures who feed off of corpses. In some games, these are undead beings risen from the grave. In others, such as those in Castlevania: Lords of Shadow, they are living beings, descended from humans who have turned into monsters after generations of living off of rotten flesh. In others, they are even referred to as being spirits.

They are similar to Zombies and often appear as more powerful versions of these.

Ghouls, like their Zombie counterparts, come in groups. There is an opportunity to steal from them when they raise their arms. They can grab the player in place and bite them several times, although they can easily break free from them.

In this game, Ghouls act and behave just like Zombies. However, they are stronger and have more health, so when first encountered, Soma will usually have to land several hits to kill them. As their weaker counterparts, they keep rising in endless hordes from the ground to march against him. They have no offensive attacks.

On the "Hard" difficulty setting, ghouls move faster and will poison Soma upon contact.