Not so much, most every woman has one breast slightly larger than the other.

In fact, taht's one way to clue on on the fake tits, is if they're too symmetrical, as sort of second base uncanny valley

It's not so much the size, but the orientation of the nipples.

Sure, much of the time it's from outer support, does't take much to shift a breast a bit(a bit of surface friction with a shirt, bra, or in this case, plaster), but it really does have that derpy appearance when they're pointing in different directions.

I blame Pareidolia, because, really, boobs can and do look like eyes/especially Garfield's