The majority of children with genetic predisposition to idiopathic acute and acute recurrent pancreatitis have the SPINK1 mutation.

Patients with SPINK1 N34S mutations were more likely to develop a Dilated duct, Calcifications, and Diabetes as Long-term Outcome of Endoscopic Treatments in Idiopathic Chronic Pancreatitis.

Evidence suggests that SPINK1 is an important growth factor that connects chronic inflammation and cancer.

Over-expression of FOXP1 (show FOXP1 Proteins) and SPINK1 may participate in the carcinogenesis of hepatitis B virus related cirrhosis.

SPINK1 plays a role as a growth factor, signaling through the EGFR (show EGFR Proteins) pathway in pancreatic ductal adenocarcinoma and neoplasms, and that the EGFR (show EGFR Proteins) is involved in the malignant transformation of IPMN.

serine Peptidase Inhibitor, Kazal Type 1 (SPINK1) Protein Profile

Protein Summary

The protein encoded by this gene is a trypsin inhibitor, which is secreted from pancreatic acinar cells into pancreatic juice. It is thought to function in the prevention of trypsin-catalyzed premature activation of zymogens within the pancreas and the pancreatic duct. Mutations in this gene are associated with hereditary pancreatitis and tropical calcific pancreatitis.