Bio-Rad® InPlace™ Columns

Overview

Bio-Rad InPlace process-scale chromatography columns are designed for industrial applications and allow contained filling, packing, unpacking, and cleaning in place for safe and hygienic column operation. To learn more about Bio-Rad InPlace columns, click on the video.

Slurry transfer methods. A, pump-mediated transfer using diaphragm pumps of the Bio-Rad media transfer device; B, vacuum-mediated transfer uses the motorized piston as a large syringe to move slurry from the tank to the column by suction.

For more information about the Bio-Rad InPlace column, request or download bulletin 6091.

Process chromatography columns must provide a very high level of cleanability to meet the requirements of various regulatory agencies. The efficiency of the column cleaning process must satisfy regulations, norms, and standards, such as cGMP, Norm ISO 13408, FDA 21-211.67, or USP 32 NF27.

Bio-Rad InPlace column and control console.

For more information about sanitization of the Bio-Rad InPlace column, request or download bulletin 6061.

Bio-Rad InPlace columns are designed so that the packing, unpacking, and cleaning-in-place features do not interfere with the bed support, distribution system, and column tube, allowing optimum performance during any operation. These columns are directly scalable and retain the same general design from pilot to manufacturing scale.

Key Features

Closed system design

Ideal for dense media

Adjustable height adaptor for axial compression

Designed for multiple packing methods

No resin loss during packing

Low mechanical shear during media transfer

Chromatography tubes available in glass, acrylic, and stainless steel

Hoist-free operation with the Bio-Rad® MainFrame™ lifting accessory

Complete documentation for regulatory submissions

18 cm–2 m size range

Bio-Rad InPlace Control Console

The Bio-Rad InPlace control console provides automation features for stand-alone InPlace process chromatography columns ranging in diameters from 18 cm to 2 m using conventional skids and media transfer. Existing InPlace columns can be upgraded to the automated InPlace control console.

Each item is delivered with CE certification and is manufactured in our facility, which is certified according to ISO 9001:2000 standards. In Bio-Rad's manufacturing procedures, all steps and components are fully documented. The qualification documentation package ensures production in compliance with U.S. and European regulations.

What is the education discount policy?

For more than 15 years, Bio-Rad has made science education a major priority. To support this effort, the company has implemented a discount policy that allows high school and college teaching laboratories to purchase kits, instruments, reagents, and other equipment at preferred prices.

How do I apply for the education discount?

If you are an educator at the high school or college level, visit our Education Discount Policy page to establish an education account number.