We elucidate differences in language network function
and intrinsic connectivity in infants, as measured by BOLD fMRI and
independent component analysis (ICA), when sedated under two common clinical
protocols; one using Nembutal and the other Propofol. BOLD response was
measured for passive story-listening stimulation using an intermittent
event-related imaging protocol with which temporal evolution of language
processing was explored. Propofol and Nembutal were found to have distinct
and complementary responses to story-listening with corroborative differences
in auditory/language network connectivity by ICA. These may suggest a
breakdown of top-down feedback for Propofol vs. the lack of bottom-up
processing for Nembutal.