I don't think VtM: Bloodlines is such a solid game that it could stand on its own in a fantasy setting, that's all i'm saying. Planescape in a fantasy setting, that's not too difficult to translate (Baldur's Gate). KOTOR = Jade Empire, similar enough. The core mechanics and design is so good that it doesnt matter that BG is typical fantasy, it still works great. Same with Jade Empire (not typical fantasy, but different enough from Star Wars).

People seems to be extremely forgiving to all of VtM: Bloodlines shortcomings because it happens to be a rare vampire RPG with a great script and great characters. I guess for some people that is enough, for me it isnt.