Application Note: Comprehensive LC/MS Analysis of Illicit and Pain Management Drugs, Including their Metabolites, in Urine

11 February 2013

This application note demonstrates that the Agilent 6420 Triple Quadrupole LC/MS system can be used to detect a wide variety of analgesic and pain management analytes in urine samples with minimal sample preparation while providing sufficient sensitivity, quantitative linearity, and accuracy. This method routinely surpasses forensic toxicology and clinical research sensitivity requirements, often down to 10 % of the desired lower limit of quantification (LLOQ), while displaying excellent linearity and reproducibility.