It's a bit tongue in cheek but it should work most of the time. A medusa would be a snake-headed woman with paralyzing rays in, say, Gamma World, while a hoop would have either a disenchanting or rusting touch in AD&D. A GURPS Eye of Death would shoot laser beams or super-science death rays in a Thundarr inspired setting. A dragon in fantasy is basically Godzilla in post-apoc. You can pretty much grab any monster book and convert quickly back and forth. You don't need a whole lot of rule work, either - a 5d burning attack from eye beams can be 5d electrical breath. Or keep the damage, etc. the same and just change the special effects.

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I was really interested in the Mutants and Magic article in the Dungeon Masters Guide on page 113. Have you ever considered mixing both high tech post apocalypse with fantasy? Maybe the nuclear war opened some portal to the fairy realm and released giants, dragons, elves and so on along with the standard mutant guys. Sort of of like Thundarr with both magic and psionics.

Well, in GURPS it's trivial to do - just add blasters and mutants to your fantasy game or spells to your post-apoc game. I happen to know at least one of my players wouldn't like me adding blasters to my DF game, so it's not going to happen. But I've obliquely pitched the idea that "we should do a DF guys in post-apoc land adventure" and that didn't get booed, so I might do that with different PCs.