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Life-Threatening Skin RashesRashes are very common conditions and can have many causes. Most rashes are not dangerous but rather are merely nuisance illnesses. Life-threatening skin rashes are rare. Five potentially life-threatening disorders that have skin rash as the primary symptom are pemphigus vulgaris (PV), Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), toxic shock syndrome (TSS), and staphylococcal scalded skin syndrome (SSSS).