To the Editor We would like to thank Dr Redberg1 for her insightful comments on the lack of comparative effectiveness evidence regarding colorectal cancer (CRC) screening methods and the need for large-scale randomized clinical trials (RCTs). We agree with the assertions by Dr Redberg that “Because colon cancer screening is recommended for all persons older than 50 years, a simple randomized trial that compared colonoscopy with fecal occult testing would accrue quickly.”1(p144) She also states that “There is no more time to lose; the time to start such a trial is now.”1(p144)