In the premiere episode, a female jogger is found floating in the Schuylkill River. Dr. Megan Hunt teams up with her partner, medical investigator and former cop Peter Dunlop, under the watchful eye of their boss, Chief Medical Examiner Dr. Kate Murphey, who is very aware of Megan's gifted but polarizing work style. Megan's colleagues, Dr. Ethan Gross and Deputy Chief Medical Examiner Dr. Curtis Brumfield, must find their own way to work alongside the new medical examiner. Megan's investigation takes her out in the field where she meets old-school cop Detective Bud Morris, who is exasperated by Megan's tenacity and bull-headedness. But his partner, Detective Samantha Baker, possesses a quiet respect for Megan's input, even if Morris doesn't. Meanwhile, as she's is trying to solve the female jogger's death, Megan has to solve a personal puzzle of her own- what is the perfect present for her daughter's 12th birthday?

When a young, interracial couple is found shot and killed inside their car in Fairmont Park, Dr. Megan Hunt promises the grieving parents that their daughter's killer will be found. Detectives Bud Morris and Samantha Baker are ready to chalk the case up to a murder-suicide, but Megan and her team find evidence on the bodies that sends the case in an entirely different and shocking direction. Meanwhile, Peter advises Megan not to push too hard when it comes to reconnecting with her daughter, Lacey.

During the autopsy of a young woman murdered in a seedy hotel room, Megan is shocked to discover her own special connection to the victim. Meanwhile, after learning to her surprise of some personal challenges her colleagues are dealing with, Megan realizes how much goes on around her that she's been missing, and takes a sudden interest, much to her colleagues' amusement.

When a severed hand and foot turn up in a back alley, Megan and her team must literally piece the victim back together. Meanwhile, Megan's daughter, Lacey, gets her mother's reluctant permission to visit her at the office and film her at work as part of a video essay for Social Studies class. What Lacey learns in the process profoundly changes her view of her mother.

Curtis questions Ethan's interest in the investigation of the mysterious death of a beautiful twin; Megan runs into resistance while investigating the death of a patient at the hospital where she used to work.

Megan re-enters the high society world to which she once belonged when a top magazine editor is found dead at her Chestnut Hill mansion. Megan accepts her mother's invitation to a social event with the ulterior motive of confronting a prime suspect, appalling her mother in the process. When Kate asks Ethan to investigate the only trace evidence found at the murder scene, he's surprised by her uncharacteristically upbeat and supportive attitude.

A perfect neighborhood in the Philadelphia suburbs is shaken when a stay-at-home dad is found stabbed to death in his home. As Megan unravels the mystery of his death and who killed him, she recalls how she learned of her own father's death. Meanwhile, Peter helps Megan juggle her biggest challenge yet, taking charge of the Saturday carpool with her hard-to-impress daughter, Lacey, and her girlfriends.

The high-profile, hit-and-run death of a Philadelphia homicide detective hits close to home with Detective Samantha "Sam" Baker. As Megan and the team dig deeper to avenge the death of one of their own, Megan realizes how important the bond between a parent and daughter is and misses her own close relationship with her daughter. Meanwhile, Megan must go to her mother, Judge Joan Hunt, with whom she has a strained relationship, to ask for her help in the investigation.

When Nikki Parkson, a philanthropic young socialite, dies, Megan suspects foul play, despite the fact that Nikki suffered from a terminal illness. Nikki's grieving mother, and brother are devastated that their attempts for a dignified funeral are halted by Megan's investigation. Further frustrating Megan's team is the fact that Nikki's body holds few clues, since she was embalmed before the autopsy. Meanwhile Kate's personal life interrupts the investigation and Lacey suspects that her parents are getting back together.