Pooled analysis data from SUNBEAM and the Phase 3 study RADIANCE Part B (n =1320) showed ozanimod did not reach statistical significance vs IFN in the time to 3-month confirmed disability progression. There was a very low rate of disability progression observed across all treatment groups by the end of the study.

Regarding safety, treatment-emergent adverse events (TEAEs) were seen in 57.2% of patients on ozanimod 0.5mg, 59.8% of patients on ozanimod 1mg vs 75.5% of patients on IFN.

Ozanimod is a novel, oral, selective sphingosine 1-phosphate 1 (S1PR1) and 5 (S1PR5) receptor modulator under investigation for immune-inflammatory conditions. Selective binding with S1PR1 is thought to inhibit a specific subset of activated lymphocytes from migrating to sites of inflammation. Selective binding with S1PR5 is thought to activate specific cells within the CNS that can potentially enhance remyelination and prevent synaptic defects.