Abstracts and presentations are embargoed for release at date and time of presentation or time of AHA/ASA news event. Failure to honor embargo policies (http://newsroom.heart.org/newsmedia/embargo-policy) will result in the abstract being withdrawn and barred from presentation.

Jump to

Abstract

Background: Long noncoding RNAs (lncRNA) are long transcripts of more than 200 nt of length not encoding for proteins; they represent a novel source of molecules with a regulatory function at transcriptional and epigenetic level; only few information are available on their role in cardiology. As different mechanisms and prognosis have been described between type 2 Diabetic (T2DM) vs NotDiabetics patients with NSTEMI, with sought to assess whether LncRNA are involved in the different phenotypes in patients with and without diabetes.

Conclusion: Our study suggests that LncRNA are pivotal player in NSTEMI because of the presence of an important dys-regulation at epigenetic level between patients with NSTEMI and CTRL; surprisingly, the larger differences were found between NSTEMI pts with and without diabetes, suggesting an important epigenetic affect in NSTEMI with T2DM .