Further Outpatient Care

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Provide surviving children with Patau syndrome the same care other children receive, including visual assessments, hearing evaluations by age 6-8 months, and immunizations.
[10] Treat health problems according to severity and always in the best interests of the child.

Specific growth charts are available for monitoring growth of children with Patau syndrome.

Inpatient & Outpatient Medications

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Prior to dental procedures, administer prophylactic antibiotics for children with cardiac anomalies.

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Deterrence/Prevention

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In each subsequent pregnancy, offer a prenatal diagnostic study to women who have had a pregnancy with an autosomal aneuploidy, including trisomy 13, 18, or 21. Such studies are also indicated when either parent is known to carry structural chromosome abnormalities involving chromosome 13. These recommendations are based on an empiric recurrence of about 1%.

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Prognosis

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Prognosis is generally quite poor for the neonate identified with Patau syndrome. Median survival is only 2.5 days; 82% die within 1 month, and 95% die within 6 months.

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Patient Education

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Although those who survive Patau syndrome have low educational potential, increased stimulation and interaction are appropriate to maximize developmental potential.

Disclosure: Serve(d) as a speaker or a member of a speakers bureau for: Alexion Pharmaceuticals, Ultragenyx Pharmaceutical, and Biomarin Pharmaceuticals<br/>Honoraria for: Alexion Pharmaceuticals, Biomarin Pharmaceuticals.

Elaine H Zackai, MD Professor of Pediatrics, Professor of Obstetrics and Gynecology, Professor of Pediatrics in Human Genetics, University of Pennsylvania School of Medicine; Director, Clinical Genetics Center, University of Pennsylvania; Senior Physician and Director of Clinical Genetics, The Children's Hospital of Philadelphia