Neurotransmitter Transporter Uptake Assay Kit, Explorer

0 Scientists have reviewed this product

No Reviews

The first live-cell kinetic assay to measure uptake of Serotonin, Norepinephrine, and Dopamine neurotransmitters

Neurotransmitter Transporter Uptake Assay Kit:

Homogeneous, live-cell fluorescent assay

Convenient, single reagent addition assay format

No use of radioactivity required

Amenable to automation and HTS

Analyze on any bottom-read fluorescent microplate instrument

Read in endpoint mode for high-throughput applications

Read in real-time kinetic mode for mechanistic studies

Neurotransmitter transporters have become important pharmaceutical targets, as they play a key role in depression and neurodegenerative diseases (NDD) such as Alzheimer’s and Parkinson’s diseases. The ability to monitor serotonin, norepinephrine and dopamine neurotransmitter uptake is key to a better understanding of these diseases. Until now, radioactively labeled compounds were used to measure serotonin, norepinephrine and dopamine transporter uptake. With the introduction of this novel assay kit, researchers will now have a tool to screen for live-cell kinetic uptake for these three key neurotransmitters in a homogeneous, fluorescence-based, high-throughput format. The assay can be performed either as a real-time kinetic assay suitable for mechanistic studies or as an HTS-amenable endpoint read.