Winthrop M. Crane (April 23, 1853 - October 2, 1920) was a U.S. political figure. He served as governor of Massachusetts between 1900 and 1903. He also served as a United States Senator from Massachusetts from 1904 until 1913. He was a Republican.

Son of Zenas Marshall Crane and Louise Fanny Laflin, Winthrop was a leading member of the Crane family of Dalton, Massachusetts, owners of the privately held Crane Paper Company, sole suppliers of the paper for the Federal Reserve Notes, the currency of the United States.

In In 1880, he married Mary Benner, who died in 1884 giving birth to their only child, Winthrop Murray Crane II. In 1906, Crane married Josephine Porter Boardman and they had three children: Stephen, Bruce, and poet Louise Crane.

He was hosting President Theodore Roosevelt in Pittsfield, Massachusetts on September 3, 1902 when a speeding trolley car rammed into the open-air horse carriage carrying Roosevelt. The accident killed the president's Secret Service agent, William Craig.

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