Hyper-IGE Syndrome, also known as job-Buckley Syndrome is an immunodeficiency syndrome, characterized by recurred staphylococcus bacterium infections and too high IGE antibodies levels. The infections can involve joints, lungs, skin and other organs. Many individuals with hyper-IGE Syndrome experience weak bones and suffer with repeated fractures.

Some people have allergy signs such as asthma, nasal stuffinnes, and eczema. The treatment of Hyper-IGE Syndrome consists of using antibiotics intermittenly or continually for the staphylococcal infection. Such antibiotics as trimethoprim-sulfamethoxazole are frequently taken as a preventive measure.