Content

P02 - Proteomic analysis of the dynamics in assembly and signaling of canonical and kinase-associated TRP channels

High-resolution quantitative proteomic analyses identified native TRPC and TRP-like channels as multiprotein complexes whose properties and cellular function(s) including assembly, signaling and processing/trafficking are encoded by the respective proteomes. For a detailed understanding of the significance and the specificity of these proteomes we will perform functional investigations in distinct cell types (together with several CRC members), analyze the dynamics of subunit assemblie(s) in various membrane compartments and unravel the interactome(s) of the kinase-associated TRP M6/7 channels in native cells.