PharmPK Discussion - PK studies in FVB mice

On 16 Jan 2007 at 21:00:15, Raysofsun (sunandshine.at.gmail.com) sent the message

Hi,I have been looking at the transport characteristics of a P-gpsubstrate drug. However, most of the in vivo studies call for the useof a particular strain of mouse, 'FVB (wild type)'. Apart from thefact that, these mice are P-gp intact and can mimic human conditionsclosely. I do not find much info about them. As in why these mice areused particulary for in vivo disposition studies. Any info/paperregarding this strain would be highly appreciated.Thanks!1Regards,Kavita