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Abstract

Polyamines are important cellular growth factors and are involved in inflammation. Both spermidine and N1-acetylspermine were identified as statistically elevated in inflammatory bowel tissue samples. Moreover, spermidine levels were also elevated in circulating mono nuclear cells of IBD patients compared to healthy controls. This observation provides the opportunity to develop an assay, which measures these polyamine markers in patient blood, patient bodily fluids, feces and/or in tissue biopsies obtained from patients. This patent claims the concept of measuring these specific markers and their use as diagnostic tools for monitoring and diagnosing disease processes such as inflammatory bowel disease and cancer.