Table 1: PI3Kgamma and PI3Kdelta inhibitor pipeline

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Table 1. PI3Kγ and PI3Kδ inhibitor pipeline.
There are at least six companies developing inhibitors that are selective for
phosphoinositide 3-kinase-d (PI3Kd) or
selective for both PI3Kg
and PI3Kd. Hematological malignancies and inflammation are
the main indications being pursued. The IC50 value indicates the
concentration of compound needed to inhibit PI3K signaling by
50% and serves as a rough measure of the relative selectivity of an inhibitor
for one isoform over another. Lower IC50 values generally indicate
greater potency.

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