Tag Archives: drugs

Functional and safety assessments of biologics prior to first-in-human (FIH) is key to understand the mode-of-action and safety profile. We have made use of an ex-vivo whole blood assay for its potential in assessment of antibody-based drug

Huntington disease (HD) is an inherited disease that causes the progressive death of nerve cells in the brain structure. In mid ages this leads to several symptoms including uncontrolled twitching movements, called chorea, emotional problems, and loss

Several debilitating diseases caused by disorders in a patient’s immune system – often called ‘immune-mediated diseases’ – have become easier to treat in the last two decades following the discovery of drugs called ‘biologics’. Biologics act on

After consumption, human and veterinary drugs or their breakdown products end up in streams and rivers via wastewater effluent discharges into water bodies. Since this is a continuous process, aquatic animals are chronically (low concentration, long-term) being

The primary source of energy for nearly all living cells is glucose. This simple molecule of sugar, a so-called monosaccharide can be found not only in sweets but also from the digestion of more complex carbohydrates molecules

Misuse of psychoactive agents is one of the most serious social issues. They are often illegal but readily available on the black market. Psychoactive drugs may lead to addiction, affect human brain, human behaviour, mood or perception

Across the population, young people are at the highest risk of developing mental health disorders but are the least likely to receive the support they require. Barriers to care been attributed to a range of issues with

Electrical activity of the heart is commonly monitored by the electrocardiogram (ECG). Such electrical activity depends on certain proteins called ion channels. These channels control the timing and the flow of electrically charged particles (ions) in and

For osteoarthritis, drugs that can delay disease progression have the potential to reduce the need for additional pain medications. But be careful which drug you chose: this effect is only shown with the prescription patented crystalline glucosamine

Cytotoxics between practice and research Cytotoxics, mainly used in cancer treatment, are defined as agents that are toxic to living cells. Therefore, their handling needs to be carefully monitored in order to protect the user. The latter

The search for new medical strategies with high therapeutic efficiencies and reduced adverse side-effects remains a challenge for the scientific community. The development of new drug delivery systems (DDS) to generate new solid forms of active pharmaceutical

Modern lifestyle is highly dependent on the use of thousands of chemicals in the form of life-saving drugs as well as specialty substances like pesticides, herbicides, cosmetics, solvents, etc. Today the discovery of a new drug costs

Marfan syndrome (MFS) is a disorder that affects different organ systems, such as the heart, aorta, eyes and the skeleton. Typically MFS patients present with tall stature, hands with long fingers, chest deformity. One of its most

Pharmacogenetics testing is relatively new to the field of psychiatry having been introduced only within recent years and at an affordable cost in the clinical setting. The case history illustrated in this report describes how pharmacogenetics testing

Angiogenesis is the new blood vessels formation in adult tissues which share some similarities to growth of blood vessels during development called vasculogenesis. It is estimated that growth of any tissue to the sizes above 2-3 mm3

Cells have characteristic sizes in different tissues from big cells like muscle cells to small cells like platelets. How is the size of a cell programmed? The answer is we don’t know. But we do know something

Innovative medicines can prevent, cure, slow or alter the evolution of diseases, and bring real value to patients. Despite increased investments in research and development, fewer medicines are being brought to market due to the increasing complexity

In recent years, the development of new drugs and therapies has decelerated despite the application of combinatorial biochemistry and new therapeutic strategies, such as nanoparticle-based drug delivery systems. Although the numbers of newly developed compounds have steadily

Although chemotherapy agents are widely used in the treatment of cancer, it is not widely known that for many patients with solid tumours, only a fraction receive a survival benefit from chemotherapy. This is particularly the case