Sakurako was the object of torment of the children she went to school with because she was born "ugly". When she confessed her love to Domyouji, he traumatized her by making fun of her looks. She was friend's with Makiko when they were still in Elementary school, but moved to Germany because of her family's business. Sakurako undergoes plastic surgery and returns to Eitoku, determined to use her new beauty to take her revenge on Domyouji by making him fall in love with her. She met Tsukushi when she asked for help at Shizuka's birthday party. She acts sweet and innocent, but lets her true colors show when she thinks no one is watching. When she hears of his growing attraction to Tsukushi, she conspires with her friend Thomas to destroy her. She has Thomas drug Tsukushi at a club and then distributes photos of the two of them in bed together around the school, causing the student body to turn on her for betraying Domyouji. When Tsukushi finds out that Sakurako is behind of this, Sakurako tells Tsukushi that she only used her in order to take revenge on Tsukasa and that she doesn't need any friends and says that ugly and average people like Tsukushi shouldn't be near handsome men like those in the F4. When Domyouji eventually refuses Sakurako's advances and sees through her plans, Sakurako becomes remorseful. She is then bullied by the whole student body because of her plastic surgery, but Tsukushi defends her. Tsukushi then says that she still can't forgive her. Sakurako also takes advantage of the situation to be near with Tsukasa when Tsukasa breaks up with Tsukushi because of her romance with Rui. But Tsukasa only pretends to be close with Sakurako to make Tsukushi jealous. At first, it's unknown whether Sakurako and Tsukushi can still be friends or not, because Sakurako becomes cruel when she is with Tsukasa. But, as the story progresses, Sakurako seems to be more friendly and sometimes defends Tsukushi from other people with malicious intent.