In 2153, Tret placed Enterprise NX-01 under quarantine when his ship detected that one of Enterprise's crewmembers, Malcolm Reed, was infected with the Loque'eque virus. Tret demanded that he be allowed to board Enterprise to eradicate the "infected organism", but Trip Tucker persuaded him to come aboard peacefully to discuss the situation.

In Enterprise's sickbay, Tret explained the virus and its origins to the crew. He then returned to his ship to deal with three more Enterprise crewmembers on the surface of the Loque'eque homeworld who had become infected during an away mission. Tret later attacked Enterprise when those infected crewmembers were returned to the ship, determined on preventing them from leaving the system. Tret ultimately relented when DoctorPhlox convinced him that he had successfully devised a cure for the virus. (ENT: "Extinction")