Before taking this quest, one may be interested in talking to one of the prisoners, Manson, and asking him about Broken Hills. There may be a long dialogue option in where he responds with "what?", this gives 500 XP.

If already talked to Jacob the Chemist and said the Chosen One likes super mutants, then go to the jail and talk to Franc, in one of the dialogue options he asks if the Chosen One hates mutants, confirm and then return to Jacob the Chemist to receive the quest.

Go to the jail and wait. Eventually, the super mutant standing guard will wander towards the door. At this time, one can pick the lock of the cells and free the two convicts. One can also steal the key from the guard, or barter for it (costs 0) and use it on the door when he leaves. Either way, the player character has to wait until the guard leaves to free them, as when the nearby guard stops the player character. With a high enough Charisma and Intelligence (both need to be 7), the main guard can also be convinced to give the key and the prisoners can leave freely.

One have to take this quest before reporting about missing people in Find the missing people for Marcus quest, or the conspirators won't talk to the player character anymore.

Once receiving this quest, one can instead turn Jacob in to Marcus for 2500 XP. Alternatively, the Chosen One can perform the break, then turn them in to Marcus. Jacob and his wife will end up in prison after a fade to black screen.