Switched to a wireless trackball several years ago because of shoulder issues. Prefer wireless because the same transmitter manages both the trackball and keyboard, so that is two less cords. Never had a problem. Turns out the repetitive motion of moving a mouse around screws up your neck and shoulder muscles, especially if the mouse pad is too high or too low. Trackball reduces a lot of arm motion. Can't recommend trackball for computer games where quick response is required. Bought one of those standing desks to try and align my arm better. Hardly use it. When I am standing, all I think about is how uncomfortable I am standing and can't focus on my work.