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I had it happen to me once...and the problem stemmed on the vehicle not being able to handle the heat..meaning the engine cooling system...Mine was a faulty thermostat it was not properly opening and closing at the right temperature anymore.. Have your engine cooling system checked.

Sounds like possible electronic fuel pump failure. when fuel pump gets weaker as the fuel level gets lower . Some folks have a tendency to run their vehicle low on fuel which will eventually shorten the life of the fuel pump.
In some cases you can fill the car up with fuel and the problem will go away in the early stages of the fuel pump problem. The problem comes back as the fuel supply in the tank gets lower. This is one sign.

look i think you maybe have a problem in the fuel tank or fuel lines because you do change the ECU and all the sensors still work if you looking for a broken hose inside the tank that produce a lost fuel pressure only when the engine is work a while or looking for stuck fuel filter o dirty injectors o vaccum hose broken o manifold vaccum leak