Imaging 5Ht7 antagonist effects in bipolar disorder

We are looking for both healthy adults and people with bipolar disorder, aged 18-60, to take part in our research study.

Participants will attend a health check screening to assess eligibility and suitable participants will be invited to take part in the study, which involves a baseline assessment day and two scanning days.

Participants will take a medication called JNJ-18038683 for one week and placebo for one week before each scan visit. JNJ-18038683, blocks the 5HT7 receptor and may be a promising new treatment for cognitive impairment in people with bipolar disorder. On each scanning day, participants will then have an MRI brain scan whilst completing computer tasks, complete a variety of mood questionnaires, and have another physical exam.

Details:

We are looking for:

You may not be able to take part if you:

have a serious medical or neurological condition

are taking certain medications

have allergies to JNJ-18038683 or other medications with 5HT7 antagonist properties such as lurasidone or vortioxetine

have recreational drug use

cannot have an MRI scan

are not using an effective contraceptive method, plan to get pregnant in the next three months, or if you are currently pregnant or breast feeding.

Location:

London

Expenses:

You will be paid £200 to compensate you for your time if you complete the study. We will also reimburse reasonable travel expenses and provide you with lunch during the scanning sessions.