GREMLIN Results:
Residue pairs sorted by strength in covariance:Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

i

j

Raw Score

Scaled Score

21_K

25_E

0.65651

2.681

42_A

51_R

0.65201

2.663

11_E

15_E

0.60357

2.465

9_D

48_R

0.46206

1.887

49_A

53_A

0.44686

1.825

10_L

55_L

0.42551

1.738

17_N

60_A

0.41847

1.709

44_T

47_T

0.41839

1.709

42_A

47_T

0.39746

1.623

15_E

21_K

0.38444

1.570

23_F

26_S

0.35847

1.464

23_F

27_L

0.35648

1.456

10_L

52_I

0.35284

1.441

52_I

56_I

0.34711

1.417

46_E

50_K

0.34309

1.401

10_L

14_L

0.33811

1.381

27_L

59_L

0.30836

1.259

50_K

54_K

0.30617

1.250

6_V

36_I

0.28249

1.154

12_A

49_A

0.28188

1.151

38_W

55_L

0.28114

1.148

45_E

49_A

0.27245

1.113

8_E

12_A

0.26956

1.101

34_E

37_R

0.26922

1.099

43_K

47_T

0.26919

1.099

54_K

58_M

0.26912

1.099

33_R

37_R

0.26813

1.095

23_F

31_Y

0.26107

1.066

53_A

57_E

0.2581

1.054

28_T

31_Y

0.25393

1.037

19_E

60_A

0.24657

1.007

30_S

33_R

0.24324

0.993

36_I

52_I

0.24023

0.981

13_A

16_A

0.23939

0.978

13_A

49_A

0.23888

0.975

4_V

33_R

0.23583

0.963

6_V

11_E

0.23444

0.957

22_E

26_S

0.22602

0.923

23_F

62_G

0.22187

0.906

47_T

51_R

0.22176

0.906

20_A

60_A

0.22163

0.905

37_R

41_S

0.22115

0.903

41_S

51_R

0.21512

0.878

7_P

48_R

0.21488

0.877

19_E

22_E

0.21361

0.872

12_A

19_E

0.21251

0.868

50_K

53_A

0.20933

0.855

14_L

59_L

0.2072

0.846

35_Y

40_N

0.20616

0.842

14_L

21_K

0.20119

0.822

20_A

59_L

0.20046

0.819

35_Y

55_L

0.19865

0.811

39_I

55_L

0.19796

0.808

51_R

54_K

0.19535

0.798

31_Y

35_Y

0.19495

0.796

6_V

21_K

0.1887

0.771

10_L

39_I

0.18714

0.764

3_E

28_T

0.1853

0.757

6_V

24_F

0.18478

0.755

9_D

45_E

0.18427

0.752

9_D

52_I

0.18426

0.752

58_M

63_K

0.18394

0.751

12_A

15_E

0.18392

0.751

34_E

41_S

0.18183

0.743

22_E

25_E

0.18128

0.740

24_F

35_Y

0.17937

0.732

27_L

37_R

0.17364

0.709

6_V

14_L

0.17157

0.701

37_R

55_L

0.17146

0.700

53_A

60_A

0.16996

0.694

7_P

10_L

0.16946

0.692

28_T

37_R

0.16938

0.692

14_L

17_N

0.16761

0.684

30_S

42_A

0.1676

0.684

13_A

17_N

0.16745

0.684

27_L

62_G

0.16652

0.680

29_P

32_R

0.16446

0.672

49_A

60_A

0.16446

0.672

25_E

32_R

0.16438

0.671

31_Y

34_E

0.16131

0.659

14_L

35_Y

0.16059

0.656

40_N

48_R

0.15838

0.647

29_P

54_K

0.15797

0.645

11_E

21_K

0.15786

0.645

8_E

45_E

0.15784

0.645

45_E

48_R

0.15755

0.643

33_R

38_W

0.15703

0.641

12_A

57_E

0.15682

0.640

29_P

33_R

0.15567

0.636

35_Y

38_W

0.15509

0.633

24_F

27_L

0.15505

0.633

24_F

54_K

0.15479

0.632

Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.

HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits: Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)