From healing songs and expressions of pain to hoodoo cure-alls and feel-good elixirs, we explore the musical world of sickness and health. We talk with Mississippi-born guitarist Little Freddie King about how the blues saved many of his nine lives. New Orleans songwriter and rocker Anders Osborne tells of a journey that led to self-medicating with pain relievers that do more harm than good, and his eventual recovery. Tim Duffy of the Music Maker Relief Foundation in North Carolina explains the curative properties of music on society and his work with Taj Mahal to help deep-roots musicians in need. And clarinetist Dr. Michael White talks of jazz and its role in his and New Orleans’ recovery after Katrina. Plus, medicine show troubadours hawk their tonics, Dr. John prescribes Mama Roux’s healing potions, and Huey “Piano” Smith gives us a serious case of “Rockin’ Pneumonia and the Boogie Woogie Flu.”

We trace the musical DNA and psychic aura of the blues from its Delta roots to Chicago’s electric pioneers, across a patchwork of regional styles and modern day innovators. In an archival interview we talk with blues rockers the Black Keys of Akron, Ohio, about defying genre, eschewing nostalgia, and the blues progenitors who blurred labels like primitive and avant-garde. Age Don’t Mean a Thing for 65-year-old Louisiana bluesman Robert Finley, who caught a big break in the last couple years and is now rocking the mic and hitting the road harder than ever. From Cadillac, Michigan to the Crescent City, Luke Winslow-King recalls the bad times and breakups that gave him a deeper understanding of the blues and inspired him to make I’m Glad Trouble Don’t Last Always. Plus, we load up the jukebox with our favorites from Howlin’ Wolf and Buddy Guy, Johnny Burnette and Buddy Holly, Willie Nelson and Bonnie Raitt.

From small town Louisiana to Memphis, from hellfire to honky tonk, we trace the meteoric rise, fall and rebound of rocknroll’s most wayward son—Jerry Lee Lewis. We talk to the Killer about his hits, his misses and being the last man standing of the “Million Dollar Quartet,” which also included Elvis, Johnny Cash and Carl Perkins. Jerry Lee’s sister Frankie Jean Lewis, a.k.a. the Chiller, gives us a tour of the family’s homestead in Ferriday, LA. Natchez, MS bluesman Hezekiah Early shares memories of Haney’s Big House, the Chitlin’ Circuit nightclub where underage Jerry Lee sneaked in to hear boogie woogie. Drummer J.M. Van Eaton describes what it was like to record with the Killer during his early Memphis days. Sun Records publicist Barbara Sims recalls the scandal that derailed the pianoman’s career. And Linda Gail Lewis, nicknamed the Thriller, tells of her brother’s second act as a country star and the string of duets they recorded together, as well as her own career as a pianist and dueting with Van Morrison. Plus, we hear Jerry Lee Lewis’s collaborations with Bruce Springsteen, Eric Clapton and Gillian Welch, among others. All killer, no filler, this week on American Routes.