Update: I was unfortunately not aware of Shamus Young's severe criticism of Fallout 3 available here to link in the original piece and I regret that. It dovetails rather nicely with what I've written and it's much better executed than my piece. I strongly recommend anyone...

Zack & Wiki: Quest for Barbaros' Treasure Cheats

Hints

Why don't You try ...This is a greta game with lots of funny and interesting things you can do in the game. So, have you...
Fed the snake a Sleeping Mushroom?
Tried to Escape Rose's airship without opening the hanger door?
Transformed the Goon Totem you used as a bridge in Bridge of Doom?
Transformed the Goon Totem stuck in the lave spout in Dragon Scales?
Killed Rose and her Goons by dropping them onto a pit of spikes?
Tried the Goblin's soup? With a Sleeping Mushroom? With a Coconut?
Transformed a Goblin Totem as it sinks into the soup?
Dived into the Fountain Guardian's pond? Without water?
Snuck up behind the King of the Jungle with a Torch?
Tried to walk on water without freezing it first in Keeper of the Ice?
Rocked the baby dragon or rubbed his head? Roughly?
Escaped Rose's airship without the map?
Been caught by the Goblins while riding the gondola?

Pirates bones
To get one of the pirates bones first You'll have to go to the ruins and u go up and find a key to open the door and then pull something to go across and find a bone.