Measures of tissue coherency in T2-weighted MRI for myelin and axonal pathology: A MRI-histology correlative study in multiple sclerosis

Shrushrita Sharma1 and Yunyan Zhang2

1Biomedical Engineering Program, University of Calgary, Calgary, AB, Canada, 2Departments of Neurology and Clinical Neurosciences, University of Calgary, AB, Canada

Measurement of tissue
coherency has been largely relying on advanced MRI. Here we presented a
coherency-assessing method based on standard T2-weighted MRI. Postmortem
brain samples from multiple sclerosis (MS) patients were used to validate our
method. It was based on Fourier transform power spectrum, from which dominant tissue-aligning
directions and angular entropy were calculated. Tissue coherency in histology
was quantified using structure tensor analysis. We found that both MRI and
histology coherency differentiated MS lesions from NAWM, and that MRI coherency
correlated significantly with histological results. These findings suggest the
potential of T2-weighted MRI in characterizing advanced tissue
pathology

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