The proliferating cell nuclear antigen, PCNA, is a highly conserved protein that performs essential functions in DNA replication and DNA repair. PCNA encircles DNA by forming a homo-trimer and interacts with a variety of proteins involved in DNA...

The ability of HIV-1 Tat to stimulate transcription initiation from the HIV LTR suggests that the basal transcriptional machinery may be targeted by Tat. Results from the study presented herein demonstrate that HIV-1 Tat binds human TBP in vitro....