Hyperbaric treatment for children with autism has reportedly led to improvements in the condition, though previous studies were uncontrolled. Now, a new study published in the open access journal, BMC Pediatrics, is the first controlled trial to report clinical improvements.

Hyperbaric therapy traditionally involves inhaling up to 100% oxygen at a pressure greater than 1 atmosphere (atm) in a pressurized chamber. In the first randomized, controlled, double-blind multicenter trial, Dan Rossignol and colleagues, from six centers in the USA, studied 62 children, aged 2-7 years, to assess the efficacy of hyperbaric treatment in children with autism.

The children were randomly assigned to either 40 hours of hyperbaric treatment at 1.3 atm and 24% oxygen (treatment group) or slightly pressurized room air at 1.03 atm and 21% oxygen (non-treatment group). Clinical outcomes were evaluated by three different scales: the Clinical Global Impression (CGI) scale, the Aberrant Behavior Checklist (ABC), and the Autism Treatment Evaluation Checklist (ATEC).

The study found that children with autism in the treatment group had significant improvements in overall functioning, receptive language, social interaction, eye contact, and sensory/cognitive awareness compared to children in the non-treatment group.

Rossignol wrote "Hyperbaric treatment is a safe treatment modality at 1.3 atm and ... appears to be a promising treatment for children with autism".

2. BMC Pediatrics is an open access journal publishing original peer-reviewed research articles in all aspects of health care in neonates, children and adolescents, as well as related molecular genetics, pathophysiology, and epidemiology. BMC Pediatrics (ISSN 1471-2431) is indexed/tracked/covered by PubMed, MEDLINE, CAS, Scopus, EMBASE and Google Scholar.

3. BioMed Central (http://www.biomedcentral.com/) is an STM (Science, Technology and Medicine) publisher which has pioneered the open access publishing model. All peer-reviewed research articles published by BioMed Central are made immediately and freely accessible online, and are licensed to allow redistribution and reuse. BioMed Central is part of Springer Science+Business Media, a leading global publisher in the STM sector.

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