About this collection

We are pleased to present our Chemical Society Reviews themed issue on Chemical signaling at the eukaryotic/prokaryotic interface, guest edited by Pieter Dorrestein (University of California, San Diego, USA) and Emily Balskus (Harvard University, USA). Organisms do not live in isolation and have co-evolved to interact. One of the main modes of interactions is through chemical signals. Such signals initiate how insects are attracted to crops, how corals are attracted to microbes to colonize and even define who we are as a human where signals from gut microbes affect our neuro-circuitry. There are many success stories but also technological advancements. The aim of this special issue is not only to describe the chemistries that have been described in the literature but also emerging advances as well as lay out a vision for the future in chemical analysis applicable to the investigations chemical signaling. In this special issue we highlight not only the state-of-the-art knowledge about signaling but also highlight the emerging advances.