..From the findings, electron microscopic features of accumulated BM material are very characteristic in hyalinizing trabecular adenomas and can be discernible from other histologic types of BM-producing tumors...

..In conclusion, the investigation of TTF-1 provides useful information on the functional activities and/or differentiation of thyroid tumors and may lead to an increase in our understanding of the biologic nature of thyroid tumors...

..We concluded that in addition to regulating growth and differentiation, TSH may function as a survival factor in thyroid cells by preventing anchorage-dependent apoptosis in FRTL-5 cells partly via the cAMP pathway...

..This observation is contrary to previously published results using the thyroid follicular culture system. Our results suggest that the direct effect of TSH/cAMP is to inhibit the VEGF synthesis in monolayer cells...

Increased expression of the sodium/iodide symporter in papillary thyroid carcinomas

..Although considerable patient-to-patient variation was observed, our results indicate that NIS mRNA is elevated, and its protein tends to be more abundant, in a subset of papillary thyroid carcinomas than in normal thyroid tissue...

..Overall, p16INK4a overexpression was seen in 87.5% of the cases (21/24). HPV DNA was not detected in any of the 24 LEGH cases. These results suggest that p16INK4a overexpression is independent of HPV infection in LEGH...

..The aim of this study was to investigate differences in the process of carcinogenesis between adenocarcinoma coexistent with LEGH and conventional adenocarcinoma. And we intend to describe appropriate treatment plans for LEGH in this study...

..These findings indicate that alteration of CT positioning could be related to DNA amplification and, morphologically, may explain the nuclear atypia that accompanies the abnormal chromatin feature...

Poorly differentiated thyroid carcinoma: the Turin proposal for the use of uniform diagnostic criteria and an algorithmic diagnostic approach

..Morphological abstraction by morphometry with factor analysis may provide a practical approach to the detection of the underlying characteristics of nuclear morphology in aspiration biopsy cytology...

..Thyroid transcription factor-1 expression associates with histologic types and/or differentiation of lung cancers and can be a valuable marker for the better understanding of their biological nature and pathological behavior...

Observer variation of encapsulated follicular lesions of the thyroid gland

Mitsuyoshi HirokawaDepartment of Pathology, University of Tokushima School of Medicine, JapanAm J Surg Pathol 26:1508-14. 2002

..To reduce observer variation of encapsulated follicular lesions, it will be necessary to provide more explicit criteria for diagnosis...

Shin Ichi MurataDepartment of Pathology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, JapanPathol Int 54:63-6. 2004

..These findings indicate that the TCC component had the cellular character of AC rather than that of TCC or squamous cell carcinomas. This is thought to be the first report of a MAcTcc of the uterine cervix...