This baseline study was commissioned by CARE International under the CARE Rwanda Patsy Collins Trust Fund Initiative (PCTFI) Cohort 3 Safe School for Girls and A Better Environment for Girls (BEE) Projects. Cohort 3 of the PCTFI started in 2015 and is expected to end in 2020. This initiative is designed to take an innovative and multi-faceted approach to understanding barriers to acquiring the skills and knowledge necessary for survival and continued human development faced by adolescent boys in girls during and beyond their formative years. This study provides and in-depth perspective on the demographics, living conditions, gender beliefs, sexual reproductive health beliefs and practices, and financial literacy of adolescent boys and girls in selected areas Rwanda, as well as information on household attitudes and beliefs, teaching attitudes, and the school environment in general. This study is based on information gathered from 1,291 adolescents, triangulated with data obtained from 1,192 adolescent heads of households, and 134 teachers from adolescent’s schools. The analyses in this study establish a baseline by which to benchmark the success of the PCTFI over the study period.