Example of several unipolar neurons from a nerve ganglion of a velvet worm (a primitive arthropod). The neurons were stained for serotonin immunoreactivity, and photographed using a confocal microscope, with multiple images overlaid and color-coded according to depth. Arrows mark the peripherally located cell bodies of several neurons, whose neurites extend into the central neuropil (np), where they ramify in a way too complex to be discernable. Scale bar: 50 micrometres.[1]

Unipolar neurons are common in insects, where the cell body is often located at the periphery of the brain and is electrically inactive. These cell bodies often send a single neurite into the brain; however, this neurite may ramify into a large number of branches making a very complex set of connections with other neurites, in regions of neuropil.

In all species, including vertebrates and invertebrates, many types of primary sensory neurons are unipolar. Typically these have special structures for transducing some type of physical stimulus (light, sound, temperature, etc.) into electrical activity, no dendrites, and a single axon that conveys the resulting signals into the spinal cord or brain.