PA, has anyone ever approached you regarding making a large quantity of Methyltrienolone?

It's a bit complex, depending on the starting materials. A legal analog was proposed to me for a company, independent of Epharm of course. Initial studies show that it's too labor-intensive for someone with limited free time on his hands to do, moreover, the propensity for federal pound me in the ass prison time is too high.

Originally Posted by Patrick Arnold

ok sandusky

I laffed pretty hard at this...

E-Pharm Nutrition Representative
WARNING: I tend to speak my mind and will verbally assault you if you are a tool. My words do not necessarily represent the official opinion of E-Pharm, but most likely, they do.

It's a bit complex, depending on the starting materials. A legal analog was proposed to me for a company, independent of Epharm of course. Initial studies show that it's too labor-intensive for someone with limited free time on his hands to do, moreover, the propensity for federal pound me in the ass prison time is too high.I laffed pretty hard at this...

If you start with trenbolone its not that hard. You protect C3 as something like an oxime or semicarbazide, then oxidize C17 using oppenauer oxidation. Then methyl grignard followed by deprotection of C3

If you start with trenbolone its not that hard. You protect C3 as something like an oxime or semicarbazide, then oxidize C17 using oppenauer oxidation. Then methyl grignard followed by deprotection of C3

I was looking more into an acetal which required TMS-protected ethylene glycol (thanks to the enone) and the use of TMSOTf as a lewis acid. Never thought to look at oximes or any other functional group other than dithianes. However, using IBX, Hg amalgam, or I2 as deprotectants wasn't my idea of a fun time. Good idea is good though. I like the Barbier reaction better

E-Pharm Nutrition Representative
WARNING: I tend to speak my mind and will verbally assault you if you are a tool. My words do not necessarily represent the official opinion of E-Pharm, but most likely, they do.

I was looking more into an acetal which required TMS-protected ethylene glycol (thanks to the enone) and the use of TMSOTf as a lewis acid. Never thought to look at oximes or any other functional group other than dithianes. However, using IBX, Hg amalgam, or I2 as deprotectants wasn't my idea of a fun time. Good idea is good though. I like the Barbier reaction better