Stan leaves Francine at home to go out with his friends Dick, Jackson and Sanders, but guys’ night out goes from wild to reckless when Stan finds himself in one compromising situation after another. After Dick has has too much to drink and hits another car outside the Cigar Bar, Stan's friends throw the driver in the trunk. Though Stan insists that they must take the man to a hospital, his friends deem him a buzz kill and go on with their activities. Stan takes Dick's keys and tries to take the man to the hospital but is stopped by a policeman who is also thrown by Stan's friends into the trunk. Despite Stan's insistence on taking the two men to the hospital, Dick instead detours to his old house to take his dog back from his recently divorced wife. Dick discovers that his ex-wife, Sheila, was dating his barber, so the guys throw him into the trunk as well. Stan's pleas to drop the three men off at the hospital are once again sidetracked when his friends pick up hookers and take them to the CIA building. However, Dick insults one of them and compels her to steal his car.

After they track the car to a powerful crime lord, Stan finally decides to hold his friends at gunpoint to force them to aid him in a rescue mission of the three men. Though the crime lord threatens to cut off Stan's leg, Stan gets out of it and presumably rescues the men with the help of his mouse companion Cheesers. Stan then shows up at work on crutches and one-legged which shocks Dick, Jackson and Sanders. Then Stan reveals he is still two-legged which causes the co-workers to laugh that Stan has a good sense of humor. They agree Stan is indeed the best man with whom to spend a night out. At the end of the episode, Stan is back spending his nights at home with Francine, but he threatens to kill the Canadian TV show host that was seen at the beginning of the episode for giving out information which did not help Stan in his rescue mission.

Meanwhile, Roger tries acting like a beauty queen, but Hayley insists that she's more attractive. They use their charm and looks to try and attract men resulting in Roger getting a date with a frat boy. However, Roger soon finds out that the party is a pig party (where college men bring unattractive girls as their dates). Roger then leaves and apologizes to Hayley for treating her as if she was ugly. He then takes her out, supposedly to get a drink, but actually as his date to the pig party although he refers to "this hog as a blue ribbon".