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Online Cover This week features a pair of Research Articles that characterize how diacylglycerol kinases (DGKs), enzymes that metabolize the second messenger diacylglycerol (DAG) to inhibit its signaling, regulate T cell receptor (TCR) responses in thymocytes. Schmidt et al. showed that loss of the ζ isoform of DGK from thymocytes resulted in enhanced TCR-dependent ERK signaling and an increase in the numbers of natural regulatory T cells generated in mice. Joshi et al. showed that although the DGKα isoform was more abundant than the DGKζ isoform in thymocytes, DGKζ appeared to be more catalytically efficient and exerted a predominant role in inhibiting TCR-dependent signaling in T cells. The image shows an artist's rendition of T cells. [Image: Chris Bickel, AAAS]