8.A.77.1.2Disintegrin, a metaloprotease (sheddase) of 824 aas and 2 TMSs near the protein's N- and C-termini. Sheds many membrane-bound proteins, especially receptors, with a preference for acidic amino acids at the P1' position. Cleaves membrane proteins and modifies their activities while releasing the proteotytic products into the external medium (Pupovac and Sluyter 2016).