Pain is the most popular stress that human face with. This study aimed to determine the fitness of emotion regulation model of generalized anxiety disorder to explain the perception of pain in patients with chronic pain. This study was conducted in the context of a correlation research the type of structural equation. The sample were consisted of 210 patients referred to a specialized pain clinics Rasht city that based on clinical interviews had generalized anxiety disorder symptom, were selected by available sampling and were completed perception of pain, emotion dysregulation, alexithymia, emotional expressivity, meta- mood and affect control questionnaires. Data were analyzed by using descriptive measures of frequency, percentage, mean, standard deviation and Pearson's correlation coefficient and structural equation model. Results showed that emotion regulation has a direct effect on pain. The expressivity, meta-mood, affect control and alexithymia have a direct effect on emotional regulation and indirect effect on pain perception. According to results, Targeting emotion regulation can be effective in reduce the perception of pain in patients with chronic pain.