The early promise of boron neutron capture therapy as a method for the treatment of brain cancer has been mainly inhibited by the inherent toxicity associated with 10B-containing pharmacophores and the need for the ability to cross biological membranes.

Atropisomers are stereoisomers that occur because of hindered rotation about a single bond, and this leads to two or more conformers that interconvert slowly enough to be isolated as single components.