Of a noble family of Toulouse, Saisset became an Augustinian canon and in 1267 was elected abbot of Saint-Antonin at Pamiers. A first dispute, with the count of Foix over the control of the city, was settled once Saisset had become bishop in 1295. But soon afterward he was denounced to Philip IV, probably by the bishop of Toulouse, from whose lands Pope Boniface VIII had carved the diocese of Pamiers for Saisset, his protégé; and in October 1301 he was charged with treason, simony, heresy, and blasphemy. Philip, faced with the prospect of executing a bishop, communicated the charges to the Pope. Boniface ordered that Philip release Saisset’s possessions and set him free to be judged by the church. Expelled from the kingdom (February 1302), Saisset went to Rome but was apparently back in Pamiers late in 1305.