The opening game of the series saw a battle of aces, as Oakland sent Dave Stewart to the hill against Boston's Roger Clemens. The game was a scoreless pitchers duel until the bottom of the fourth, when Red Sox third baseman Wade Boggs launched a solo home run off Stewart. Despite mounting scoring threats in each of the next two innings, the Athletics failed to deliver against the "Rocket."

In the ninth, the wheels came off for the Red Sox bullpen, as Oakland blew the game wide open by erupting for seven runs. Henderson led the way with a two-run single and a stolen base, Terry Steinbach and Willie Randolph added RBI base hits, and Canseco chipped in with a sacrifice fly. Despite the game being far from a save situation, A's closer Dennis Eckersley shut Boston down in the bottom half of the inning. giving Oakland a 9–1 victory and a 1–0 series lead.

In the sixth, Boston manager Joe Morgan pulled Kiecker in favour of the bullpen, and as they had in Game 1, the A's went to work. Mike Gallego and Rickey Henderson ripped consecutive singles, and McGee forced Henderson, moving Gallego to third. He came home on a groundout by Baines, giving the A's a 2–1 advantage. In the ninth, the Athletics extended their lead to three runs, courtesy an RBI double by Baines and a run-scoring single by McGwire. Eckersley worked a 1–2–3 ninth to secure his first save of the series, and Oakland carried a 2–0 ALCS lead back to the Coliseum.

For Game 3 in Oakland, the Red Sox threw Mike Boddicker, who had been the 1983 ALCS MVP with the Baltimore Orioles, against the Athletics' Mike Moore. In the second, the Red Sox drew first blood when Mike Greenwell walked, moved up to third on a single by Dwight Evans, and came home on a sacrifice fly by Tom Brunansky. Boston continued to lead until the bottom of the fourth, when the A's struck for two runs. Canseco and Baines both got on base and then executed a double steal, enabling Canseco to subsequently score on a Dave Henderson sacrifice fly and Baines to eventually plate on a single by Randolph.

In the sixth, Oakland added a pair of runs to their lead thanks to some shoddy fielding by the Red Sox. An error by Rivera on a ground ball allowed Baines to reach base, take second on a fly out by McGwire, then move to third when Dave Henderson was forced out by Steinbach. An RBI single by Randolph scored Baines and moved Steinbach to third. Steinbach then boldly tried to steal home and was gunned down, but an error by his Boston counterpart Tony Peña resulted in another run. In the ninth, Eckersley picked up his second save as the A's took a 3–0 stranglehold on the series.

The fourth game was a pitching rematch of Game 1, as Stewart again faced Clemens. In the bottom of the second, the "Rocket" gave up consecutive singles to Lansford and Steinbach, and both advanced one base due to a throwing error by Greenwell. McGwire then forced Steinbach, driving in Lansford with the first run of the game.

Randolph was the next batter, and when home plate umpire Terry Cooney adjudged Clemens' fifth pitch to him to be ball four, the Red Sox ace lost his composure, letting loose a stream of profanities. Although Clemens later claimed he was talking to his glove, Cooney assumed the comments were directed at him and promptly ejected Clemens from the game. Upon realizing he had been ejected, Clemens charged at the umpires, while Peña and Boston manager Joe Morgan fiercely argued the call. The Red Sox bench also exploded, with Clemens' indignant teammates hurling water coolers and litter onto the field. In the end, Clemens, Morgan, and Marty Barrett were thrown out; an angry Barrett had merited his ejection by having to be physically restrained from leaving the dugout and confronting the umpiring crew.[5]

The ejection proved to be the turning point of the game, as Gallego proceeded to belt a double to center field off Clemens' replacement, Tom Bolton, scoring both McGwire and Randolph. The Red Sox briefly mounted a last-ditch rally in the top of the ninth, scoring a single run courtesy an Ellis Burks double and a single by Jody Reed, but Athletics reliever Rick Honeycutt got Greenwell to ground out, handing Oakland its third straight American League pennant. This would be Oakland's last postseason series win until 2006.