Adults: ≥18yrs: Give consistently with regard to meals and time of day. 1.25mg/kg twice daily; may increase by 0.5−0.75mg/kg/day after 8wks and again after 12wks; max 4mg/kg/day Concomitant MTX: may treat with 3mg/kg/day or less. Reduce dose by 25−50% if adverse events (eg, hypertension or SCr increases ≥30% above baseline) occur. Children: <18yrs: not established.

Adults: 7.5mg once weekly using oral or SC form. Use of alternative MTX forms: see full labeling. Children: <2yrs: not established. 2–16yrs: Initially 10mg/m² once weekly. Use of alternative MTX forms: see full labeling.

Adults: Initially 7.5mg once weekly as a single dose, or a course of three 2.5mg doses at 12‑hr intervals once weekly; max 20mg/wk. Children: <2yrs: not recommended. ≥2yrs: Initially 10mg/m² once weekly; max 20mg/m²/wk.

Adults: Take after meals. Initially 500mg in the PM for 1wk, then 500mg in the AM & PM for 1wk, then 500mg in the AM and 1g in the PM for 1wk, then 1g in the AM & PM in 2 evenly divided doses. Children: <6yrs: not recommended. ≥6yrs: Initially ¼ to ⅓ of maintenance dose; increase weekly. Maintenance: 30−50mg/kg/day in 2 evenly divided doses; max 2g/day.

Adults: ≥18yrs: 40mg every other week. RA (without MTX): may increase frequency to once weekly. Children: <2yrs or <10kg: not recommended. 2−17yrs: (10kg−<15kg): 10mg every other week (10mg prefilled syringe should be used); (15−<30kg): 20mg every other week (20mg prefilled syringe should be used); (≥30kg): 40mg every other week.

Adults:RA, psoriatic arthritis: 400mg (two 200mg inj at separate sites) SC on Day 1, then at Weeks 2 and 4, followed by 200mg every other week. Maintenance: may consider 400mg every 4wks. Ankylosing spondylitis: 400mg on Day 1, then at Weeks 2 and 4, followed by 200mg every 2wks or 400mg every 4wks. Children: Not established.

Adults: Infuse over 30min. 2mg/kg IV at Weeks 0 and 4, then every 8wks thereafter. May continue to use corticosteroids, non-biologic DMARDs, and/or NSAIDs during treatment. RA: give with MTX. Psoriatic arthritis, ankylosing spondylitis: may give with or without MTX or other non-biologic DMARDs. Children: <18yrs: not established.

Adults: ≥18yrs: 45mg SC once then 4wks later, followed by 45mg every 12wks. Co‑existent moderate-to-severe plaque psoriasis weighing >100kg: 90mg once then 4wks later, followed by 90mg every 12wks. Children: <18yrs: not established.

Adults:Active psoriatic arthritis: Day 1: 10mg in AM. Day 2: 10mg in AM and 10mg in PM. Day 3: 10mg in AM and 20mg in PM. Day 4: 20mg in AM and 20mg in PM. Day 5: 20mg in AM and 30mg in PM. Following on Day 6 and thereafter: 30mg twice daily (AM & PM). Children: <18yrs: not established.

Adults: Give glucocorticoids 30mins prior to each infusion. First infusion: initially at a rate of 50mg/hr; may increase by 50mg/hr increments every 30mins. Subsequent infusions: initially at a rate of 100mg/hr; may increase by 100mg/hr increments every 30mins. Both: max 400mg/hr if infusion reactions do not occur. In combination with MTX: two 1000mg separated by 2wks. Subsequent courses should be given every 24wks or based on response, but not sooner than every 16wks. Children: Not established.