The two saddest tear jerking moments from two arguably one of the bittersweet series. Open the spoilers at your own risk, since it contains one of the biggest spoilers for the series. I have included a youtube link of the scene if you wanted as well.

Honey & Clover - Hanamoto and Rika

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This is after when Hanamoto and Rika have lost Harada, their best friend (husband as well for latter) after a car crash. As Hanamoto tries to stop Rika from committing suicide after losing her husband, as well as being permanently crippled, when he sees her in perpetual pain on top of a building, he decides to end it all. As his hands were about to push her, she notices him, and he realizes what he was about to do. Despite being only a flashback, this is arguably one of the saddest scene in any anime.

This is as Tomoya and Ushio come back home by train, as he tries to describe Nagisa, his late wife, to his daughter. As he tries to reminisce about her, his grievance towards her causes tears to fall abruptly, unable to stop. The scene is powerful enough to make you feel sympathetic for him, even if you haven't watched the series yet.

well they r alot actually ....hard 2 specify some of em but i remember yuki from gravitation omg he didnt cry for damn six years and that was A LOT TIME AGO...........and then naruto in gaarais death was like a crying baby ,his tears lukt sincere