Antibodies to Cyclin Family - Product Review 16

Introduction

Oscillations in the activity of the Cdk family of protein kinases drive the eukaryotic cell cycle. These enzymes consist of a catalytic (Cdk) and a regulatory subunit (Cyclin).

Their activity is regulated by phosphorylation of Cdks, binding of stoichiometric kinase inhibitors and regulated proteolysis of the cyclins.The Cdk/cyclin family contains five Cdks (Cdk1, 2, 3, 4 and 6) and four cyclin classes (cyclin A, B, D and E, see table below.) that regulate the cell cycle; three Cdks (Cdk7, 8 and 9) and three cyclin classes (cyclin C, H and T) that regulate transcription. Activating the cell-cycle Cdks requires phosphorylation of a conserved threonine as well as binding of cyclin.

Antibody Tools for Detection of Cyclin Proteins

OriGene Technologies offers a broad panel of monoclonal and polyclonal antibodies for the immunological detection of members of the Cyclin protein family.