Growth Hormone Fails to Slow Alzheimer’s

A new study shows that a drug that increases the release of growth hormone failed to slow the rate of progression of Alzheimer’s disease in humans.

Growth hormone is naturally produced in the body and stimulates the release of another hormone called insulin-like growth factor-1 (IGF-1). Studies on mice have suggested that IGF-1 helps reduce beta-amyloid, which is a form of plaque, from the brain.

The accumulation of beta-amyloid is a core feature of Alzheimer’s disease and is thought to be an important cause of the memory and behavioral symptoms of the disease.

In the study, scientists used the investigational compound MK-677 to boost the blood levels of the hormone. MK-677 stimulates the release of natural growth hormone from the pituitary gland. The growth hormone then stimulates the release of IGF-1 in other parts of the body.

The study involved 416 people who had mild to moderate Alzheimer’s disease who underwent brain scans. Half of the group took MK-677 and the other half took a placebo for one year.

The study found that MK-677 did not slow the symptoms of Alzheimer’s disease even though MK-677 was effective in increasing levels of IGF-1.

“This work suggests that targeting this hormone system may not be an effective approach to slowing the rate of Alzheimer’s disease progression,” says study author J.J. Sevigny, MD, of Merck Research Laboratories in North Wales, PA.

“Importantly it challenges the common theory that hormones may attack beta-amyloid plaque in the brain and builds on the body of clinical evidence for Alzheimer’s disease as we seek to develop more effective treatments.”

It is estimated that every 70 seconds, someone in the United States develops Alzheimer’s disease. There are only five drugs that are FDA approved to treat the symptoms of the disease.

The study was supported by Merck Research Laboratories and is published in the November 18 print issue of Neurology®, the medical journal of the American Academy of Neurology.

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About Rick Nauert PhD

Dr. Rick Nauert has over 25 years experience in clinical, administrative and academic healthcare. He is currently an associate professor for Rocky Mountain University of Health Professionals doctoral program in health promotion and wellness. Dr. Nauert began his career as a clinical physical therapist and served as a regional manager for a publicly traded multidisciplinary rehabilitation agency for 12 years. He has masters degrees in health-fitness management and healthcare administration and a doctoral degree from The University of Texas at Austin focused on health care informatics, health administration, health education and health policy. His research efforts included the area of telehealth with a specialty in disease management.