Placebo (mimic of cholecalciferol) in the same amount and same time frame as Cholecalciferol for 12 months

Primary Outcomes

Measure

MRSA

time frame:
Baseline, 3, 6, 9 and 12 months

Secondary Outcomes

Measure

Vitamin D levels in serum

time frame:
baseline, 3, 6, 9, 12, 18 and 24 months

Eligibility Criteria

Male or female participants from 18 years up to 75 years old.

Inclusion Criteria:
1. Persistent MRSA-carriers as defined as 2 MRSA-positive bacterial cultures from at
least one location, at least 3 months apart and during 3 years prior to inclusion.
2. Men and women aged ≥18-75
3. Signed 'informed consent'
4. Negative pregnancy test (U-hcg) and have to accept the use of adequate
anti-conceptive method (contraceptives, hormone/copper-spiral).
Exclusion Criteria:
1. Should not be on vitamin D supplementation at least 6 months prior to inclusion.
2. Serum level of 25-hydroxy vitamin D3 >75 nmol/L
3. Ongoing and continuous antibiotic treatment. The patient should be off antibiotics at
least 30 days prior to inclusion
4. Known sarcoidosis
5. Primary or secondary hyperparathyroidism
6. Kidney failure as defined as a normal age-adjusted creatinin.
7. Long term systemic treatment with corticosteroids or other immunosuppressive
medication
8. Taking thiazides
9. Hypercalcaemia (verified by a laboratory result younger than 2 month)
10. Ongoing malignancy disorder
11. If plans to leave the Stockholm county within 12 months of inclusion
12. History of kidney stones
13. Pregnancy (ongoing or planned)
14. Breastfeeding women
15. Taking part of another clinical study involving drugs
16. Hypersensitivity to cholecalciferol and/or any of the excipients
17. Other criteria that could jeopardize the study or its intention as judged by the
investigator