Big Madam was a powerful and influential Ghoul, with an extensive black market network. In the past, Big Madam raised Juuzou Suzuya as a human "pet" and subjected him to extensive abuse. Nutcracker was believed to be one of their employees, and was considered a major target by CCG.

Big Madam was severely wounded by Juuzou's "Jason", and begged for mercy. Juuzou said he never hated Big Madam, but merely had to kill her because that was his "job". Infuriated, Big Madam said she had never loved Juuzou but was immediately killed by the Squad members. As Big Madam was killed, Hanbee covered the saddened Juuzou's eyes and ears, as he said his final farewell and addressed her as "father".