Drug Ingredient Information

AMOXICILLIN-500MG+CLAVULANIC ACID-125MG

AMOXICILLIN

Information for
patients

Drug Information

Amoxicillin are antibiotics. The contain a medicine called amoxicillin. This belongs to a group of medicines called ‘penicillins’. Amoxicillin is used to treat infections in different parts of the body caused by bacteria. It is also used to stop infections when you have a tooth removed or other surgery. Amoxicillin may also be used in combination with other medicines to treat stomach ulcers

Drug Alert

Alert

•are allergic (hypersensitive) to amoxicillin, penicillin.
•have ever had an allergic (hypersensitive) reaction to any antibiotic. This can include a skin rash or swelling of the face or neck.
Do not take Amoxicillin if any of the above apply. If you are not sure, talk to your doctor or pharmacist before taking Amoxicillin.

Before Consuming
the Medicine

Avoid Drug

•are allergic (hypersensitive) to amoxicillin, penicillin.
•have ever had an allergic (hypersensitive) reaction to any antibiotic. This can include a skin rash or swelling of the face or neck.
Do not take Amoxicillin if any of the above apply. If you are not sure, talk to your doctor or pharmacist before taking Amoxicillin.

Drug Special Care

Check with your doctor or pharmacist before taking this medicine if you:
•have glandular fever
•are being treated for kidney problems
•are not passing water regularly.
If you are not sure if any of the above apply to you, talk to your doctor or pharmacist before taking Amoxicillin.
Having urine or blood tests
If you are having tests on your water (urine glucose tests) or blood tests for liver function, let the doctor or nurse know that you are on Amoxicillin. This is because Amoxicillin can affect the results of these tests.

Drug Drug Interactions

Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines. This includes medicines that can be bought without a prescription and herbal medicines. This is because Amoxicillin can affect the way some other medicines work. Also some other medicines can affect the way Amoxicillin works.
•If you are taking allopurinol (used for gout) with Amoxicillin, it may be more likely that you’ll have an allergic skin reaction.
•If you are taking probenecid (used for gout), your doctor may decide to adjust your dose of Amoxicillin.
•If medicines to help stop blood clots (such as warfarin) are taken with Amoxicillin then extra blood tests may be needed.Amoxicillin may stop the contraceptive pill working. You will need to use extra contraceptive precautions, such as using a condom. If you need any advice, talk to your doctor or pharmacist.

Drug Pregnancy Interaction

Ask your doctor or pharmacist for advice before taking any medicine if you think you might be or if you are pregnant, or if you are breast-feeding.

Drug Breast feeding Interaction

Ask your doctor or pharmacist for advice before taking any medicine if you think you might be or if you are pregnant, or if you are breast-feeding.

Drug Machinery Interaction

Drug More Information

How to take the
Medicine

Consumption Info

Drug quanitty

Children weighing less than 40 kg who are able to swallow.All doses are worked out depending on the child’s bodyweight in kilograms.
•Your doctor will advise you how much Amoxicillin you should give to your baby or child.
•Usual dose – 40mg to 90mg for each kilogram of body weight a day given in two or three divided doses
Adults, elderly patients and children weighing over 40 kg
•Standard dose: 1 x 250 mg capsule 3 times a day.
•Severe infections: 1 x 500 mg capsule 3 times a day.
•Severe or recurrent chest infection: 3 g (6 x 500 mg ) twice a day.
•Urinary tract (water) infection: 2 x 3 g doses (6 x 500 mg ) with 10 to 12 hours between each dose.
•Dental abscess (infection under the gums and teeth): 2 x 3 g doses (6 x 500 mg ) with 8 hours between each dose.
•Gonorrhoea (a sexually transmitted infection): 1 x 3 g dose (6 x 500 mg ).
•Stomach ulcers: 1 x 750 mg dose (3 x 250 mg or 1 x 500 mg capsule and 1 x 250 mg capsule) or 1 x 1 g dose (2 x 500 mg ) twice a day for 7 days with other antibiotics.
To stop infection during surgery
•The dose will vary according to the type of surgery. Other medicines may also be given at the same time.
•Your doctor, pharmacist or nurse can give you more details.
Kidney problems
If you have kidney problems the dose might be lower than the usual dose.

Drug Dose

•Swallow the whole with a glass of water at the start of a meal or slightly before
•Space the doses evenly during the day, at least 4 hours apart
•Never take 2 doses in 1 hour
•The maximum recommended dose is 6 g per day given as 2 x 3 g doses

Excess Drug Consumption

If you have too much Amoxicillin, signs might be an upset stomach (feeling sick, being sick or diarrhoea) or crystals in the urine, which may be seen as cloudy urine, or problems passing urine. Talk to your doctor as soon as possible. Take the medicine to show the doctor.

Forgot Drug Consumption

•If you forget to take a dose don’t worry, take it as soon as you remember.
•Don’t take the next dose too soon, wait about 4 hours before taking the next dose.

Stop Drug Consumption

•Keep taking Amoxicillin until the treatment is finished, even if you feel better. You need every dose to help fight the infection. If some bacteria survive they can cause the infection to come back. Treatment should be continued for 2 to 3 days after the symptoms have gone.
•Do not take Amoxicillin for more than 2 weeks. If you still feel unwell you should go back to see the doctor.
Thrush (a yeast infection of moist areas of the body) may develop if Amoxicillin is used for a long time. If this occurs and you have been taking Amoxicillin for longer than recommended, tell your doctor. If you have any further questions on the use of this product, ask your doctor or pharmacist.

•thrush (a yeast infection of the vagina, mouth or skin folds), you can get treatment for thrush from your doctor or pharmacist
•kidney problems
•fits (convulsions), seen in patients on high doses or with kidney problems
•dizziness
•hyperactivity
•crystals in the urine, which may be seen as cloudy urine, or difficulty or discomfort in passing urine. Make sure you drink plenty of fluids to reduce the chance of these symptoms
•teeth may appear stained, usually returning to normal with brushing (this has been reported in children)
•the tongue may change to yellow, brown or black and it may have a hairy appearance
•an excessive breakdown of red blood cells causing a form of anaemia. Signs include: tiredness, headaches, shortness of breath, dizziness, looking pale and yellowing of the skin and the whites of the eyes
•the blood may take longer to clot than it normally would. You may notice this if you have a nosebleed or cut yourself

Drug Side Effects Symptoms

•allergic reactions, the signs may include: skin itching or rash, swelling of the face, lips, tongue, body or breathing difficulties. These can be serious and occasionally deaths have occurred
•rash or pinpoint flat red round spots under the skin surface or bruising of the skin. This is due to inflammation of blood vessel walls due to an allergic reaction. It can be associated with joint pain (arthritis) and kidney problems
•a delayed allergic reaction can occur usually 7 to 12 days after having Amoxicillin, some signs include: rashes, fever, joint pains and enlargement of the lymph nodes especially under the arms
•a skin reaction known as ‘erythema multiforme’ where you may develop: itchy reddish purple patches on the skin especially on the palms of the hands or soles of the feet, ‘hive-like’ raised swollen areas on the skin, tender areas on the surfaces of the mouth, eyes and private parts. You may have a fever and be very tired
•other severe skin reactions can include: changes in skin colour, bumps under the skin, blistering, pustules, peeling, redness, pain, itching, scaling. These may be associated with fever, headaches and body aches
•high temperature (fever), chills, a sore throat or other signs of an infection,or if you bruise easily. These may be signs of a problem with your blood cells
•inflammation of the large bowel (colon) with diarrhoea sometimes containing blood, pain and fever
•serious liver side effects may occur which are often reversible. They are mainly associated with people having treatment over a long period, males and the elderly. You must tell your doctor urgently if you get:
-severe diarrhoea with bleeding
-blisters, redness or bruising of the skin
-darker urine or paler stools
-yellowing of the skin or the whites of the eyes (jaundice). See also anaemia below which might result in jaundice. These can happen when having the medicine or for up to several weeks after.

How to Store the
Medicine

How to Store the Medicine

•Keep out of the reach and sight of children.
•Do not use Amoxicillin after the expiry date which is stated on the carton. The expiry date refers to the last day of that month.
•Store in the original pack below 25°C.
•Do not use Amoxicillin if there are visible signs of deterioration.
•Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment

CLAVULANIC ACID

Information for
patients

Drug Information

Clavulanic acid is a ß-lactam drug that functions as a mechanism-based ß-Lactamase inhibitor. While not effective by itself as an antibiotic, when combined with penicillin-group antibiotics, it can overcome antibiotic resistance in bacteria that secrete ß-lactamase, which otherwise inactivates most penicillins.