Looking narrowly at markets and the central-bank-fueled recovery we've seen in the developed world since the 2008 global financial crisis, the UK's vote Thursday to exit the EU ushers in an era in which the belief that what ought to happen will happen has gone out the window.

Animal spirits, or a market-based enthusiasm for buying risky assets on any signs of trouble with the belief that policymakers will correct course quickly, are no more.

In a note to clients on Friday morning, Deutsche Bank strategist George Saravelos said simply, "Goodbye animal spirits."

He added:

"Beyond the UK and Europe, the impact of tonight runs beyond the geopolitical implications: yesterday the market was pricing a 90% probability of remain. The surprise of the result and the unpredictability of the political process will impose a big cost on the market's self-confidence, ability and willingness to take risk. In a world already pre-disposed to secular stagnation, the hit to animal spirits and the market's risk-taking capacity will be big."

But Saravelos' commentary is emphasizing that while there will be some shocking dislocations in markets on Friday, and most likely in the days and weeks to come, the long-run impact of this vote is only just beginning.

The world has changed, the market will need to readjust, and everything we thought we knew now needs to be reexamined.

In September, I wrote that with the Federal Reserve looking to begin raising interest rates, the party, at least for US stocks, was over. And sure, Fed policy has ushered in a more unsettled era for markets.

But calling an end to parties is merely a market-speak way to say things are changing. It's a familiar turn of phrase, though of course not all parties are created equal.

And after the UK's world-order-shattering vote to leave the EU, this earlier call now seems quaint.