Early stage investigators
of exceptional creativity proposing research of uncommonly high potential
impact

Individuals or teams
proposing transformative research that requires very large budgets

Outstanding junior
scientists wishing to 'skip the postdoc' and move directly to independent
research

Investigators with
extraordinary records of cancer research productivity proposing exceptional
research

Year introduced

2004

2007

2007

2011

2014

Eligibility

Open to all career stages.
Early and middle career researchers particularly encouraged to apply. Must
currently be engaged in research

Receipt
of most recent doctoral degree or completion of medical internship and
residency no more than 10 years prior to application receipt date. Must be a 'new
investigator' who has never been awarded an R01 or equivalent NIH grant

Open to all career stages

Candidate must receive
doctoral degree or complete medical residency within
12 months before or after application submission date

Candidate must have
received an NCI grant for the last five consecutive years

Research proposal
requirements

Three- to five-page essay
to address the challenge, potential impact and suitability for the Pioneer
Award program and how the proposed studies qualify as new research direction.
Preliminary data not required but may be included

Ten-page essay to address
significance and potential impact and innovativeness of proposed approach,
how risks and challenges will be addressed, and how investigator
qualifications meet 'exceptional creativity' criteria. Preliminary data not
required but may be included

Twelve-page essay to
address the challenge, potential impact and appropriateness for the
Transformative Research Awards program. Preliminary data not required but may
be included

Twelve-page component to
address matters of candidate suitability and research vision. Host
institution must provide details of commitment. Preliminary data not required
but may be included

Twelve
pages describing the investigator's seminal programmatic contributions to
their own or related fields of cancer research and how they have influenced
current thinking and will continue to do so. They will address a major
biomedical or behavioral problem or challenge in cancer research, the
importance of this problem or challenge and the researcher's qualifications
to engage in groundbreaking cancer research. Research strategy is expected to
evolve during tenure of the grant

Budget

No detailed budget
information needs to be submitted. Awards will be for up to $500,000 in
direct costs each year, plus standard indirect costs

No detailed budget
information needs to be submitted. Awards will be for up to $300,000 in
direct costs each year, plus standard indirect costs

No limits to maximum funds
available for the program as a whole. No prior approvals required for budgets
over $500,000 in direct costs each year

Up to $250,000 in direct
costs for each year granted, plus standard indirect costs

Up to $600,000 in direct
costs for each year granted

Award duration

5 years

5 years

Up to 5 years

Up to 5 years

Up to 7 years

Review format

Multiphased review, with an
interview of finalists by external peers

Multiphased review,
including review by external editorial board

Multiphased review,
including review by external editorial board

Multiphased
review, including review by external editorial board and an interview of
finalists

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