In this study,
we used diffusion tensor imaging and graph theoretical approaches to
investigate the whole-brain white-matter connectional architecture in ADHD
patients. We found disrupted topological organization of whiteCmatter
structural networks in ADHD patients. Both decreased and increased
connections in the patients were mainly located in the frontal regions,
insula and striatum structures, providing evidence for the hypothesis of
abnormal fronto-striatal-insular circuitry in ADHD. Specifically, the
disrupted connections in the fronto-insular component were associated with
the inattention performances in patients, improving our understanding of the
potential mechanisms underlying the behavior deficits in patients with ADHD.