B0041.7 Aff_B0041.7 PWAll gene names:slr-8; xnp-1; B0041.7; 1F234; CE17314;
NM_059022; WBGene00006961; WP:CE17314
WormBase description:xnp-1 encodes an ATP-dependentDNA helicase of the SNF2 family that is orthologous to
human XNP/ATR-X, which is associated with a number of
X-linked mental retardation syndromes; in C. elegans,
xnp-1 activity is required at high temperatures for
embryogenesis, somatic gonad development, fertility,
and vulval morphogenesis; in addition, animals doubly
mutant for xnp-1 and lin-35/Rb, hpl-2/HP1, or
nucleosome remodelling and histone deacetylase (NuRD)
complex members such as lin-53 and let-418, display
larval arrest with growth cessation but continued cell
proliferation; xnp-1 is also required, with lin-35/Rb
and hpl-2/HP1, for proper regulation of transgene
expression; xnp-1 mRNA, detectable in embryos and the
germline by in situ hybridization, is expressed at
highest levels in embryos with decreasing levels seen
in successive larval stages; xnp-1 transcriptional
reporter fusions exhibit strong expression beginning at
mid-embryogenesis but fading by embryonic
morphogenesis; at hatching, expression is observed in
all dividing cells including the P lineage, and at
later larval stages expression is observed in the
vulval precursor cells.
WormBase CDS description: helicase

B0304.1 Aff_B0304.1 PWAll gene names:hlh-1; B0304.1; 2E811; CE02423;
CE30067; CE31766; MyoD1; WBGene00001948; WP:CE02423;
WP:CE30067; WP:CE31766
WormBase description:hlh-1 encodes a basic
helix-loop-helix (bHLH) transcription factor that is
the sole C. elegans member of the myogenic regulatory
factor (MRF) subgroup of bHLH proteins; in C. elegans,
HLH-1 activity is required during embryonic development
for the proper differentiation and function of body
wall muscle cells, indicating that unlike its
vertebrate counterparts, hlh-1 is not absolutely
required for body wall muscle specification; however,
ectopic expression of hlh-1 in the embryo is sufficient
to convert nearly all embryonic cell types to a
muscle-like fate; in regulating body wall muscle cell
development in some cell lineages, hlh-1 likely lies
downstream of the PAL-1 homeodomain protein that is
required for specification of the C and D founder cell
fates; HLH-1 is expressed in nuclei and first appears
in body wall muscle precursors beginning at the
~80-cell stage of embryogenesis; expression then
continues in these cells and their differentiated
descendants throughout embryonic, larval, and adult
stages of development.
WormBase CDS description: helix-loop-helix
transcription factor

B0511.1 Aff_B0511.1 PWAll gene names:fkb-7; B0511.1; 1L245; CE26851;
NM_060391; WBGene00001432; WP:CE26851
WormBase description:fkb-7 encodes a peptidylprolyl
cis/trans isomerase homologous to mammalian
FK506-binding proteins; by homology, FKB-7 could
function in a number of different processes including
protein folding, signal transduction, and regulation of
muscle contraction; however, as loss of fkb-7 function
via RNA-mediated interference (RNAi) does not result in
any obvious abnormalities, the precise role of FKB-7 in
C. elegans development and/or behavior is not yet
known.

C02B8.2 Aff_C02B8.2 PWAll gene names:C02B8.2; CE03891; WBGene00015321;
WP:CE03891; XI761C02F5.1 Aff_C02F5.1 PWAll gene names:knl-1; C02F5.1; 3J343; CE02450;
NM_066410; WBGene00002231; WP:CE02450
WormBase description:knl-1 encodes a novel acidic
protein with a coiled-coil region at its C-terminus;
KNL-1 is an essential kinetochore component that is
required for proper spindle elongation and chromosome
separation, and in the kinetochore assembly pathway,
plays a key role in linking the initiation of
kinetochore formation with the construction of a
functional microtubule-binding interface; in the
assembly pathway, KNL-1 functions downstream of the
DNA-proximal kinetochore components CeCENP-A/HCP-3 and
CeCENP-B/HCP-4 and upstream of the outer kinetochore
components HIM-10/Nuf2p, NDC-80/HEC1, CeBUB-1, HCP-1,
and CeCLASP2/CLS-2; in expression studies in the
one-cell embryo, KNL-1 localizes to kinetochores
throughout mitosis.

C03B1.12 Aff_C03B1.12 PWAll gene names:lmp-1; C03B1.12; C03B1.12.1;
C03B1.12.2; CE03912; NM_076671; WBGene00003053;
WP:CE03912; XG996WormBase description:lmp-1 encodes a protein with
similarity to vertebrate lysosome-associated membrane
proteins CD68, and appears to be the only protein in C.
elegans that has a GYXX (phi) vertebrate lysosomal
targeting sequence at its carboxy terminus; localized
to the periphery of a large population of membrane
bound organelles (granules) seen throughout the early
embryos and restricted to the cells of the intestine
during later stages.

C04F6.3 Aff_C04F6.3 PWAll gene names:cht-1; C04F6.3; C04F6.3.1; C04F6.3.2;
CE03923; CHT1; NM_076187; WBGene00000503; WP:CE03923;
XE16WormBase description:cht-1 encodes a chitinase
orthologous to human chitinase-1 (OMIM:600031,
mutations are associated with chitotriosidase
deficiency); CHT-1 is predicted to function as an
extracellular O-glycosyl hydrolase that hydrolyzes the
glycosidic bond between two or more carbohydrates; in
C. elegans, CHT-1 may play a role in embryogenesis, and
may also be required for cuticle degradation during
molting and degradation of chitin-containing pathogens
as part of a host defense mechanism.
WormBase CDS description: glycosyl hydrolase (family
18)

C05E4.1 Aff_C05E4.1 PWAll gene names:pes-21; C05E4.1; 5B243; CE07935;
NM_070917; WBGene00005643; WP:CE07935
WormBase description:srp-2 encodes an ovalbumin-like
serpin (ov-serpin) member of the serine protease
inhibitor superfamily that is orthologous to human
NEUROSERPIN (OMIM:602445, mutated in familial
encephalopathy with neuroserpin inclusion bodies);
SRP-2 is predicted to function as a suicide substrate
that inhibits the proteolytic activity of serine
proteases, and in vitro, recombinant SRP-2 is able to
inhibit granzyme B activity; however, as loss of srp-2
function via RNA-mediated interference (RNAi) does not
result in any obvious abnormalities, the precise role
of SRP-2 in C. elegans development and/or behavior is
not yet known; srp-2 expression is detected in
hypodermal cells, particularly in the lateral seam
cells.
WormBase CDS description: serine protease inhibitor

C06G4.2 Aff_C06G4.2 PWAll gene names:clp-1; C06G4.2; C06G4.2a.1; C06G4.2a.2;
C06G4.2b.1; C06G4.2b.2; C06G4.2b.3; 3J75; CE00517;
CE30486; CE37743; CE37744; NM_066339; NM_066340;
NM_171201; NM_171886; WBGene00000542; WP:CE00517;
WP:CE30486; WP:CE37743; WP:CE37744
WormBase description:clp-1 encodes a calpain homolog
that has significant identity to mammalian calpains
over its whole length and that contains motifs typical
of calpains, including a thiol (cysteine) protease
active site and a Ca[2+]-binding domain; CLP-1 is
required, in parallel with TRA-3 but in series with
ASP-3 and ASP-3, for degenerative (necrotic-like) cell
death in neurons induced by mutations such as mec-4(d),
deg-3(d), or gsa-1(gf).

C32F10.2 Aff_C32F10.2 PWAll gene names:lin-35; C32F10.2; 1G391; CE24823;
NM_059285; WBGene00003020; WP:CE24823
WormBase description:lin-35 encodes the C. elegans
retinoblastoma protein (Rb) ortholog; lin-35 was first
identified in screens for synthetic multivulva (synMuv)
genes and as a class B synMuv gene, functions
redundantly with class A genes to antagonize Ras
signaling and negatively regulate vulval development;
in addition, lin-35 activity is required redundantly
with: 1) pha-1 and ubc-18 for early steps in pharyngeal
morphogenesis, 2) fzr-1 for normal patterns of
postembryonic proliferation, 3) xnp-1 for somatic gonad
development, and 4) psa-1 for fertility and embryonic
and larval development; on its own, lin-35 is also
required for wild-type levels of fertility; LIN-35 is
expressed broadly in embryos and L1 larvae, but in
later larvae and adults is detected in vulval precursor
cells and their descendants as well as a subset of head
and tail cells.

C34E10.7 Aff_C34E10.7 PWAll gene names:cnd-1; hlh-5; C34E10.7; 3G328; CE01187;
NM_065714; WBGene00000561; WP:CE01187
WormBase description:cnd-1 is orthologous to the human
gene NEUROGENICDIFFERENTIATION 1 (NEUROD1;
OMIM:601724), which when mutated leads to disease.
C34F11.4 Aff_C34F11.4 PWAll gene names:msp-50; C34F11.4; 2F491; NM_062571;
WBGene00003443WormBase description:msp-50 encodes a protein that
belongs to a family of proteins called the Major Sperm
Proteins (MSPs) that is conserved in nematodes; this
family consists of closely related, small, basic
proteins that make up 15% of sperm protein; this
multigene family consists of over fifty genes,
including many pseudogenes; MSPs are involved in both
extracellular signaling and cytoskeletal functions
during reproduction-MSP antagonizes Eph/ephrin
signaling, in part, by binding VAB-1 Eph receptor
tyrosine kinase on oocytes and sheath cells to promote
oocyte maturation and MAPK activation; MSPs assemble
into fibrous networks that drive movement of the C.
elegans sperm; msp genes are expressed only in late
primary spermatocytes.
WormBase CDS description: major sperm protein

C38C10.4 Aff_C38C10.4 PWAll gene names: ags-3.3; gpr-2; C38C10.4; 3K482;
CE00107; NM_066665; WBGene00001689; WP:CE00107
WormBase description:gpr-2 encodes a protein
containing a GPR (G Protein Regulator)/GoLoco motif
characteristic of guanine nucleotide exchange factors
specific for G-alpha GTPases; GPR-2 appears to function
redundantly during early embryogenesis and germ-line
development to regulate chromosome and spindle
movements during cell division; GPR-2 likely acts as a
positive regulator of G protein signaling and
specifically, may regulate GOA-1 signaling in the
embryo; GPR-2 forms a protein complex with the nearly
identical GPR-1 and with LIN-5, a coiled-coil protein
that is required for proper localization of GPR-2 to
the cell cortex and spindle asters of the early embryo;
in addition, proper GPR-2/GPR-1/LIN-5 localization
between the P2 and EMS blastomeres at the four-cell
stage, which may contribute to spindle positioning in
EMS, requires the MES-1/SRC-1 tyrosine kinase signaling
pathway; GPR-2 is believed to act downstream of, or in
parallel to, PAR-3, a PDZ domain-containing protein, in
mitotic spindle positioning in the early embryo.

C43D7.8 Aff_Y116F11.I PWAll gene names:C43D7.8; 5T784; CE18552;
WBGene00008070; WP:CE18552
WormBase description: This gene encodes a protein
containing an F-box, a motif predicted to mediate
protein-protein interactions either with homologs of
yeast Skp-1p or with other proteins.

Member of lists (Publications lists):

ViswanathanM et al 2005 S2 daf-16
Resveratrol

C43E11.10 Aff_C43E11.10 PWAll gene names:cdc-6; C43E11.10; 1E838; CE08688;
NM_058942; WBGene00000382; WP:CE08688
WormBase description:cdc-6 encodes a homolog of an
origin complex component (CDC6) which in yeast controls
the start of DNA replication, and also has a distant
paralog (Y39A1A.12) within the C. elegans genome; CDC-6
is superficially dispensable for embryonic viability,
perhaps because of redundancy with Y39A1A.12.

C45G3.1 Aff_C45G3.1 PWAll gene names:tag-255; C45G3.1; 1J798; CE15710;
WBGene00008107; WP:CE15710
WormBase description: The C45G3.1 gene encodes a
protein, with one N-terminal calponin-like
actin-binding domain and two IQ calmodulin-binding
domains, that is likely to be required for spindle
structure and function, and (indirectly) for neural
function, based on its orthology to Drosophila ABNORMALSPINDLE and on its joint sterile and uncoordinated RNAi
phenotypes; C45G3.1 is also orthologous to human ASPM
(OMIM:605481), which when mutated leads to primary
microcephaly; C45G3.1 is required for embryonic and
larval viability, germline maintenance, vulval
morphogenesis, meiosis, and locomotion.
WormBase CDS description:Actinin-type actin-binding
domain containing proteins

C52E2.1 Aff_C52E2.I PWAll gene names:fbxb-95; C52E2.1; C52E2.I; 2C127;
CE25826; WBGene00016880; WP:CE25826
WormBase description: This gene encodes a protein
containing an F-box, a motif predicted to mediate
protein-protein interactions either with homologs of
yeast Skp-1p or with other proteins; this gene's
encoded protein also contains an FTH/DUF38 motif, which
may also mediate protein-protein interaction.

D1081.2 Aff_D1081.2 PWAll gene names:unc-120; D1081.2; 1J37; CE05534;
NM_059895; WBGene00006844; WP:CE05534
WormBase description:unc-120 encodes a member of the
MADS-box family of transcription factors that contains
human and Drosophila serum response factor (SRF) and
Saccharomyces cerevisiae MCM1 and ARG80; UNC-120 is
required for locomotion and muscle development and for
formation of the normal number of muscle A and I bands;
UNC-120 is also required for maintaining wild-type
expression levels of the muscle components actin and
myosin; UNC-120 is first expressed in the early embryo
in body wall muscle precursors and later is expressed
in both body wall and vulval muscles.
WormBase CDS description:MADS domain

F10E9.8 Aff_F10E9.8 PWAll gene names:dcd-1; sas-4; F10E9.8; 3J404; CE29756;
NM_066427; WBGene00004726; WP:CE29756
WormBase description:sas-4 encodes a predicted
coiled-coil protein and centriole component recruited
to the centrosome once per cell cycle at the time of
organelle duplication and is required for centriole
duplication and spindle assembly, levels dictate
centrosome size, and also affects germ cell
proliferation and locomotion; colocalizes with
gamma-tubulin to centrosomes both in sperm and in the
syncitial part of the gonad.

F25E2.5 Aff_F25E2.5 PWAll gene names:daf-3; F25E2.5; CE26364; CE28002;
CE30963; NM_075760; WBGene00000899; WP:CE26364;
WP:CE28002; WP:CE30963; XB438WormBase description:daf-3 encodes a Smad protein;
DAF-3 functions as a transcriptional regulator that is
required for formation of the alternative dauer larval
stage; DAF-3 activity is antagonized by signaling
through the DAF-7/TGF-beta pathway which promotes
reproductive growth; in yeast two-hybrid studies, DAF-3
interacts with SMA-3, another Smad protein that does
not appear to have a role in dauer formation; a
DAF-3::GFP fusion protein is expressed in many tissues
that undergo remodeling during dauer development; DAF-3
localizes predominantly to the cytoplasm, but is also
found associated with chromosomes in mitotic cells.

F26F12.7 Aff_F26F12.7 PWAll gene names:chd-4; evl-11; let-418; F26F12.7;
5G311; CE17716; NM_072122; WBGene00002637; WP:CE17716
WormBase description: The let-418 gene encodes a
homolog of Mi-2/CHD3, a component of the nucleosome
remodeling and histone deacetylase (NURD) complex;
LET-418 is similar to DNA helicases, homologous to
human AIRE (OMIM:607358, mutated in autoimmune
polyendocrinopathy syndrome), and paralogous to CHD-3;
with MEP-1, LET-418 is required to repress
germline-specific genes in somatic cells, and also
negatively regulates RAS-dependent postembryonic vulval
development (via the synMuvB pathway); LET-418 and
CHD-3 are redundantly required for specification of
secondary cell fates in vulval development; LET-418 is
expressed in all interphase nuclei throughout
development; LET-418 is bound by MEP-1, and also
interacts with HDA-1 and PIE-1; these interactions
probably reflect repression of LET-418 by PIE-1 in the
germline.
WormBase CDS description:DNA helicase

F40H6.4 Aff_F40H6.4 PWAll gene names: CE-TBX-11; tbx-11; F40H6.4; 3H134;
CE01281; NM_065916; WBGene00006547; WP:CE01281
WormBase description:tbx-11 encodes a T-box
transcription factor that is orthologous to members of
the Tbx2 subfamily of T-box transcription factors; by
homology, TBX-11 is predicted to function in
transcriptional regulation during cellular
differentiation, potentially as both an activator and a
repressor; however, as loss of tbx-11 function via
large-scale RNAi screens does not result in any obvious
abnormalities, the precise role of tbx-11 in C. elegans
development and/or behavior is not yet known.

Member of lists (Publications lists):

Reinke et al 2004, list of genes in
cluster order

F41C6.1 Aff_F41C6.1 PWAll gene names:unc-106; unc-6; F41C6.1; F41C6.1.1;
F41C6.1.2; CE04538; NM_076764; WBGene00006746;
WP:CE04538; XH515WormBase description:unc-6 encodes a netrin
orthologous to the human and mouse netrin-1 precursor
proteins; UNC-6 functions as a guidance molecule that
regulates the migrations of pioneer axons and
mesodermal cells, such as the gonadal distal tip cell,
along the dorsoventral axis; a secreted molecule, UNC-6
is expressed during embryogenesis by epidermoblasts and
neurons; UNC-6 is involved in both attractive and
repulsive interactions that are mediated by the UNC-40
and UNC-5 netrin receptors, respectively.

F53B2.6 Aff_F53B2.6 PWAll gene names:ham-1; F53B2.6; 4N309; CE17851;
NM_070000; WBGene00001820; WP:CE17851
WormBase description:ham-1 encodes a novel protein
with a winged helix DNA-binding motif; ham-1 is
required for the asymmetric divisions of several
neuroblasts in the developing embryo and may influence
their spindle position; ham-1 mutations also exhibit
HSN motor neuron migration defects; HAM-1 interacts
with itself in a yeast two-hybrid screen and
observations suggest that its multimerization is
required for its proper localization; HAM-1 is
cytoplasmic and is asymmetrically distributed to the
posterior of the HSNPHB neuroblast.

F56A12.1 Aff_F56A12.1 PWAll gene names:mig-3; unc-39; F56A12.1; 5O855;
CE37921; NM_074162; WBGene00006775; WP:CE37921
WormBase description:unc-39 encodes a homeodomain
transcription factor that belongs to the Six4/5 family
of homeodomain proteins that includes human Six5;
UNC-39 is required for axonal pathfinding in
anterior-derived neurons and for specification of most
mesodermal cell types and may regulate a developmental
decision between migration and differentiation; UNC-39
is expressed in the embryo in anterior neurons,
posteriorly derived mesoderm (somatic gonad, M
mesoblast, and possibly the coelomocytes and muIntR),
the CAN neurons, and body wall muscle.
WormBase CDS description: so class homeobox protein

F57F5.4 Aff_F57F5.4 PWAll gene names:add-2; F57F5.4; F57F5.4.1; F57F5.4.2;
5M490; CE06002; NM_073612; WBGene00000073; WP:CE06002
WormBase description:add-2 encodes a protein
containing an alpha-adducin-like head domain that while
highly similar in sequence to the head domain of
vertebrate and Drosophila adducins, atypically resides
at the C-, rather than N-, terminus of the protein; by
homology, ADD-2 is predicted to be a cell
membrane-associated cytoskeletal protein that mediates
cytoskeletal rearrangements in response to activation
of signal transduction cascades; as loss of add-2
activity via large-scale RNAi screens does not result
in any obvious abnormalities, the precise role of ADD-2
in C. elegans development and/or behavior is not yet
known.

K03A1.6 Aff_K03A1.6 PWAll gene names:his-38; K03A1.6; NM_076830;
WBGene00001912; XH928WormBase description:his-38 encodes an H4 histone; by
homology, HIS-38 is predicted to function as a
nucleosome component required for packaging of DNA into
chromatin; his-38 is a replication-dependent histone
locus that does not reside in a cluster, but exists as
a single histone locus on the X chromosome.
WormBase CDS description:histone-H4

K07F5.1 Aff_K07F5.1 PWAll gene names:msp-81; K07F5.1; 4K600; NM_069358;
WBGene00003467WormBase description:msp-81 encodes a member of the
major sperm protein family.
WormBase CDS description: major sperm protein
K07F5.2 Aff_K07F5.2 PWAll gene names:msp-10; K07F5.2; 4K603; CE03853;
NM_069359; WBGene00003425; WP:CE03853
WormBase description:msp-10 encodes a protein that
belongs to a family of proteins called the Major Sperm
Proteins (MSPs) that is conserved in nematodes; this
family consists of closely related, small, basic
proteins that make up 15% of sperm protein; this
multigene family consists of over fifty genes,
including many pseudogenes; MSPs are involved in both
extracellular signaling and cytoskeletal functions
during reproduction-MSP antagonizes Eph/ephrin
signaling, in part, by binding VAB-1 Eph receptor
tyrosine kinase on oocytes and sheath cells to promote
oocyte maturation and MAPK activation; MSPs assemble
into fibrous networks that drive movement of the C.
elegans sperm; msp genes are expressed only in late
primary spermatocytes.
WormBase CDS description: major sperm protein

K08D10.8 Aff_K08D10.8 PWAll gene names:K08D10.8; K08D10.8.1; K08D10.8.2;
4E929; CE07360; WBGene00019531; WP:CE07360
WormBase description:K08D10.7 encodes a homolog of
human scramblase (PLSCR1; OMIM:604170), which is
activated by a rise of intracellular calcium, and which
promotes the exposure of phosphatidylserine on the
surface of cells undergoing activation, injury, or
apoptosis; a close paralog of K08D10.8 is K08D10.7, and
other paralogs include F46A8.9, F46A8.10, and Y50E8A.9>
Exposure of phosphatidylserine on the surface of
apoptotic cells occurs because of a phospholipid
scramblase and inactivation of an aminophospolipid
translocase that would normally keep the PS on the
interior of the cell; by virtue of its similarity to
mammalian scramblase, K08D10.8 may promote clearage of
apoptotic cells by phagocytosis.

K10B4.6 Aff_K10B4.6 PWAll gene names:Wnt-1; cwn-1; K10B4.6; 2A422; CE12072;
CE33421; WBGene00000857; WP:CE12072; WP:CE33421
WormBase description:cwn-1 encodes one of five C.
elegans Wnt signaling ligands; although the precise
developmental role of cwn-1 is not yet known, during
embryogenesis cwn-1 likely functions as a downstream
target of the PAL-1 homeodomain protein in the
regulatory network that specifies cell fates in the C
lineage that gives rise to ectodermal and muscle
tissue; consistent with this role, loss of cwn-1
activity via RNAi results in rare larval tail defects
that may result, in part, from abnormal morphogenesis
of C lineage descendants; a cwn-1 reporter is expressed
in C and D muscle cells, as well as in two posterior C
ectodermal cells; cwn-1 mRNA is detectable at all
developmental stages, with highest levels of expression
seen in embryonic stages.

M05B5.5 Aff_M05B5.5 PWAll gene names:hlh-2; M05B5.5; M05B5.5a.1; M05B5.5a.2;
1H768; CE06191; NM_059633; WBGene00001949; WP:CE06191
WormBase description:hlh-2 encodes a Class I basic
helix-loop-helix (bHLH) transcription factor that is
the C. elegans ortholog of the mammalian E and
Drosophila Daughterless transcriptional activators;
HLH-2 activity is required for cell fate specifications
occuring during embryonic and larval development that
affect such processes as gonadogenesis, male tail
formation, and programmed cell death; HLH-2 has been
shown to dimerize with at least two C. elegans
Acheate-scute homologs, LIN-32, a neural-specific
protein with which it functions in male tail
development and HLH-3, with which it is coexpressed in
the nuclei of embryonic neuronal prescursors and with
which it regulates the transcription of the EGL-1 cell
death activator in the NSM sister cells; in
gonadogenesis, HLH-2 is required for bestowing proAC
competence on the cells that undergo the AC/VU (anchor
cell/ventral uterine precursor) cell fate decision, for
specification, differentiation, and function of the
distal tip cell (DTC) and AC, including transcriptional
regulation of the LAG-2Delta-like ligand in the
latter, and for formation of the uterine seam cell
(utse); genetic analysis also suggests that HLH-2
functions with HLH-14, an additional Acaete-scute
homolog, to specify the PVQ/HSN/PHB neuroblast cell
lineage; HLH-2 is expressed in all nuclei of early
embryos until the ~200-cell stage, when expression
becomes increasingly restricted to neuronal cells and
their immediate precursors; later expression is
detected in, but not limited to, pharyngeal cells,
anterior neurons, vulval and uterine muscles, the DTCs,
the presumptive and mature AC, the Q neuroblast, and
enteric muscles; comparative analysis of
transcriptional and translational reporters indicates
that hlh-2 is expressed in both the anchor cell and the
ventral uterine (VU) precursor, but that expression in
the latter is subject to post-transcriptional
down-regulation; HLH-2 accumulation in the presumptive
AC is the first detectable difference between the AC
and VU precursors during the lateral specification
event that distinguishes these two cell fates.
WormBase CDS description: transcription factor E2-A
like