MicroRNAs and epigenetic mechanisms of rhabdomyosarcoma development
M Cieśla, J Dulak, A Józkowicz - The International Journal of Biochemistry & Cell …, 2014
Abstract Rhabdomyosarcoma is the most common type of soft tissue sarcoma in children.
Two main subtypes of rhabdomyosarcoma with different molecular pattern and distinct
clinical behaviour may be identified–embryonal and alveolar rhabdomyosarcoma. All ...

Recurrent Orbital Adult-Type Fibrosarcoma in a 3-Year-Old Girl
RM Hussain, BP Erickson, AE Rosenberg, SR Dubovy… - 2014
... Adult-type fibrosarcoma most often presents in patients aged 30 to 55 years
old.1 It is important to differentiate fibrosarcoma of the orbit from rhabdomyosarcoma,
the most common primary pediat- ric orbital malignancy. The ...

The mechanistic target of rapamycin pathway in sarcomas: from biology to therapy
M Farid, L Ahn, A Brohl, A Cioffi, RG Maki - Expert Opinion on Orphan Drugs, 2014
... Rhabdomyosarcoma is an aggressive tumor of skeletal muscle affecting predominantly children
and young adults; it is treated with multimodality therapy, with prognosis dependent on
histopathological subtype, extent of surgical resection and anatomic site of origin. ...

The Role of miR-605 and its Variant in Li-Fraumeni Syndrome
I Badr - 2014
... RISC RNA-induced Silencing Complex RMS Rhabdomyosarcoma Ser Serine ... 1969 whilst studying
families of children diagnosed with a rare soft-tissue tumor called rhabdomyosarcoma 63 . Upon
retrospective analysis, they discovered that five of these families ...

There is an important kind of rhabdo clinical trial that is presently hindered by lack of bio-specimens. Specifically, the trials focus on creating individualized therapies for relapsed rhabdo patients. In ... Read More