Ghost in the Shell 2: Man/Machine Interface (攻殻機動隊2 MANMACHINE INTERFACE, Kōkaku Kidōtai 2: Manmachine Interface?) is an eleven chapter manga written and drawn by the mangaka Masamune Shirow (士郎 正宗 Shirō Masamune). It was first released in Japan in a serialized format in Young Magazine by Kodansha. The same publisher later collected these works with significant changes into the limited SOLID BOX hardcover in 2000. In 2001, the mainstream softcover was released with more changes. It was first released in the US in 2003 by Dark Horse Comics.

The sequel to the original Ghost in the Shell manga series, GITS2 explores a wide range of philosophical issues regarding the nature of human identity and the boundaries of human consciousness. However, the action of the series is largely tangential to the plot of the original work and its various cinematic and televisual offspring (Ghost in the Shell: Stand Alone Complex, Ghost in the Shell: S.A.C. 2nd GIG, and the film Ghost in the Shell 2: Innocence directed by famed Japanese auteur Mamoru Oshii).

GITS2 owes much to the conventions of cyberpunk and readers familiar with that genre may immediately recognize the questions raised by Shirow. As such, the overall philosophical terrain is not entirely new; rather, the work might instead be considered an extended rumination, punctuated by complex action sequences, upon many of the same issues brought up in the original Ghost in The Shell manga.