Results :
In eyes with nAMD, the mean deviation (mean ± SD) was -7.7 ± 5.5 dB for mesopic, -9.8 ± 5.0dB for DA cyan and -7.9 ± 4.9dB for DA red testing. For mesopic testing, RF regression could explain without LOO-CV 50.5 % and with LOO-CV 24.1 % of the variability in point-wise sensitivity. Hereby, the ONL (19.1 %IncMSE) and OS thicknesses (16.9 %IncMSE) were the most important predictive features. For DA cyan and red testing, the R2 values were without LOO-CV 40.8 % and 51.5 % or with LOO-CV 22.5 % and 30.6 %. Again, the ONL (18.3 and 14.5 %IncMSE) and OS thicknesses (13.7 and 15.6 %IncMSE) were the most important predictive features.

Conclusions :
The larger deviation for DA cyan testing as compared to DA red testing is indicative of a more severely impaired rod than cone function in nAMD. Volumetric SD-OCT data may explain a significant proportion of the variability of mesopic and scotopic dysfunction. Besides layer thicknesses, SD-OCT reflectivity profiles and fundus autofluorescence data may provide even more accurate prediction of retinal sensitivity impairment.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.