Sex and Weight

Alcohol is highly hydrophilic, so once it enters the systemic circulation, it is distributed evenly throughout total body water (Vd, or the volume of distribution). In general, the larger the person the larger the Vd, so that if two different sized males drink the same quantity of alcohol, a higher peak concentration will be reached in the lighter of the two because he will have a smaller Vd for the alcohol to distribute itself throughout. Similarly, because women have more body fat compared with men, and fat contains no water, higher peak alcohol levels are achieved in women than in men of the same weight. The Vd of alcohol for adult males has been shown to be approx 0.70, compared with 0.60 for adult females (129).

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