You can sustain off his minions. Wait for his ult to go off. Kill. He is oppressive, but if you farm you will be stronger after level 9.

3

Galio

You probably can't kill Galio, but neither can he, without help. Be out of taunt range and save your W for it just in case. Farm up.

4

Dr. Mundo

Try to kill him pre-six, if you can you will crush. If not, bully and farm, but he's too tanky after 6.

4

Garen

His silence and ult are troublesome, but overall you can poke him down and win. Make sure to throw an AA or Q so his passive doesn't heal him.

4

Nasus

Be aggressive and don't let him stack, call for some ganks or kill him yourself once your health is higher then his in lane by a decent margin.

4

Riven

Her cc is hard to deal with, but you can kill her in an extended fight. Just save your W for her ult. Skill matchup.

4

Teemo

You will out scale, just survive laning phase. Start ruby crystal until you see if it is AP/AD, and be extra careful if he has ignite. Overall though it is easy kills after level 9. Grab a pink ward to avoid embarrassment.

4

Tryndamere

Ult after he ults. Do normal lane things and you will win.

4

Yasuo

Yasuo's wind wall does not block ult or Q, but does block E. He can get to you quick and a very very aggressive Yas will be very challenging. Otherwise poke and farm, and you may even kill him. His danger ranges from a 3 to a 9 based on skill, and is the most unpredictable matchup here.

5

Fizz

Can't catch this annoying champ, and he will bait you then burst you down. Play safe and farm.

5

Gangplank

Kill his barrels. Kill his barrels. Farm and kill. Skill Matchup.

5

Jax

Jax can jump and cc, but isn't that bad overall. Farm up and get some tankiness, and try to get a gank.

5

Maokai

He won't kill you, but you can't kill him. Deal with it and outfarm.

5

Rumble

Skill matchup. A good Rumble will have the advantage, so it is usually best to play it safe and farm up. Don't underestimate ultimate.

5

Shen

You can't kill him easily if he builds right. Just try to push lane hard when he ults away and ping when he is missing. Nothing worse than being flamed.

5

Singed

Skill matchup. His flip and poison will kill you, eventually, and he is very tanky. Farm it out.

5

Volibear

Don't try to kill. His passive will be the literal death of you. His cc and surprising damage will kill you, so play very safe. Not to bad if you play it right though.

5

Kled

Haven't actually played it, but be wary of his health reset. He is AD and good early, so best play it safe.

6

Olaf

Olaf can get to you fast and has poke that goes through minions. Skill matchup.

6

Poppy

Skill matchup. Don't let her stun you into walls, and outfarm. Be very sure if you are going for a kill, because she can turn it around on you quickly.

7

Ekko

Ekko's cc, poke and ult make him difficult to fight and kill. He can dash to you as well, so be safe and avoid in teamfights. Remember to W if he tries to Ult on top of you.

7

Nautilus

Nautilus has a damaging sheild, a root, a hook, and a stunning ult. Be very careful. You'll be fine past level 9 but he has potential to dominate early game, and may even try diving before level 6 so be careful early and have a lot of health.

7

Camille

Similar to Fiora, but not quite as bad. Avoid the stuns and farm up.

8

Darius

Farm it out. Poke if you can and try to keep the minions towards your side.

8

Renekton

Rene can get to you and get out with his combo while having okay sustain from his q, and great sustain with his ult. You can't fight him with his stun, so farm up and call for ganks.

8

Swain

Another hard matchup. Ban in ranked if you are playing Vlad, since it is a good ban right now anyway. He out sustains you with ult and has cc. His nerf to his R cooldown will make things easier on 6.13 and beyond.

8

Trundle

Trundle can get to you and out sustain. Plus he steals your health on a tanky Vald build. Play safe and farm it out.

8

Wukong

For some reason, Wukong always seems to cause problems. His clone can block your E damage too. Grab a pink ward and play safe, and gauge how skilled he is.

9

Fiora

Vlad has trouble vs AD, and Fiora is too good at bursting down. Be safe and farm at tower.

9

Irelia

Irelia can cc, dash, and does true damage, very difficult match-up. You can out skill, but be wary. Best bet is too farm up. Now with Trinity Force buff she is even more deadly.

9

Pantheon

If you find yourself against him, try to farm under tower. Panth is very punishing and is a difficult matchup, just cs. In addition Panth can gank other lanes while you are oppressed.

Top Vladimir Build

I have been playing since Season 3 and found that Vladimir was my main from Season 4 on. I play a lot of different positions and champs frequently but can never let go of Vlad as my true main. After Season 6 Mid-season Vlad got some buffs and nerfs, but as Season 7 goes on he is more or less in the same place but with better items than before. I am currently Gold this season and think this guide will aid any inspiring Vlad Main.

Farming and Auto-attacking

The difference between a good and amazing Vlad player is how you cs and how much you get. This is even more obvious since the Season 6 mid-season rework, with E now actually damaging you in a significant way. Get good at basic attacking minions for CS. It is a pain with Vlad, but the rework did add some AD to your basic attack to make it easier (unless you had it memorized before XD) The new changes to Doran's Sheild will help if you get that first buy. Your E will eventually one shot back line minions if you are pushing, and make sure you position yourself with your E to hit all minions. Vlad's E is now like Ashe's W, and doesn't hit everything in the range. You should always aim to have the most cs in the game as Vlad, through laning phase, available jungle camps, pushing out lanes, and defending.

Runes

After recently switching to building 30CDR again, I want to make sure I don't cap out cooldown so I have 6 scaling cooldown gylphs and 3 AP ones. I prefer scaling health for seals, and the quints (3AP) and marks (9 MP) are pretty standard.

Masteries

For Masteries I typically run 18-0-12 with Deathfire. Storm Raider's is another option, but Vlad benefits far more from the Ferocity page than the Cunning page. I personally take Battle Trance but taking Bounty Hunter will just make a slight difference. Finally I take Insight for more flash plays and since Perseverance isn't all that great.

Items

I have always been a fan of Doran's sheild and pot start, and now with its recent buffs it is a good start again. Another option is boots, if you are worried about early ganks. For trinket always start Warding Totem, gotta spot those incoming ganks.
I typically back when the other laner leaves or I reach around 1300 gold. There is no reason to back first with your sustain unless you know you'll die. If you are ahead and feeling good your first item should be Protobelt, so build a Hextech Revolver. Otherwise start building Spectre's Cowl for Spirit Visage if your vs. AP and if you're vs. AD grab a Seeker's Armguard to build into Zhoyna's. If you want to build SV or PB and want early cooldown, or only have 800 gold, Kindlegem isn't bad either. Honestly I have found that either Protobelt or Visage first item works versus AP champs, so go with your gut and gauge whether you are winning lane or not. In addition try to get Boots of speed if you haven't.
Spirit Visage is a must unless they have absolutely no AP damage. Zhoyna's is a great way to get extra damage and wait for cooldowns, and heal of your ultimate so unless they have no AD it should be picked up as well.
Protobelt adds some movement utility and gives Vlad an extra pop when bursting champs initially, along with health, AP, and CD. Right now I like Merc Treads for that Tenacity, and even with Ninja Tabi being nerfed it is stilla great buy against comps with more AD. I like Swifty Boots for that extra movement speed, but I rarely ever need it or buy it anymore, I would rather have Mercs. I used to always go Sorcerer's, but it just isn't necessary for Vlad to do damage.
For my fourth item I usually go Void Staff since they have accumulated enough MR at this point. The MP is very useful and you should be durable enough already. For the final item I have been between Ryali's and Liandry's, but I have found that Rylai's is only really good if you are really ahead early and falls off quick since your E is already a slow, so I have been picking up Liandry's. Liandry's is another great AP/Health item that also gives 15MP.
End game for trinkets I still prefer to keep the basic wards, since it it nice to have some stealthy wards with Mid and ADC typically getting blue trinket. In addition it helps set up teleports. Get Oracle Lens for specific champs like Vayne, Teemo, Akali, etc. For consumable you can either go Sorcery or Iron. Sorcery is nice for extra AP and turret damage, but the mana regeneration is wasted. Iron is great giving Vlad health, size increase, and tenacity which is stellar. In addition it increases ally movement speed, so I typically chose Iron. But again, game dependent.
Banshee's new change seems great for Vlad, but you usually don't need anymore MR after Spirit Visage, and now that SV's passive gives #0% increased healing it is definitely a better option. Same could be argued for Abyssal Mask, so these two items are good pickups if you have a Heavy AP enemy team and they could replace Zhoyna's or Liandry's. Rylai's is good early as a first item when majorly ahead or mid game to catch up to mobile ADCs so it is situational. Deathcap is an alternative for your last item as well, or instead of Void Staff if they don't have much MR. For heavy enemy AD teams I have found that Randuin's Omen is a good buy, assuming they have Crit Chance. If not you can go Deadman's for some extra move-speed if you don't AA during fights. Thornmail's update is beneficial for Vlad due to the added health, and in addition adds grievous wounds. Would get this for a second armor item if they have lifesteal.

Skill Sequence

In every game I always max Q first, as its a great last hit tool, it provides sustain, and what's the point of being a vampire if you don't take the enemies blood! Be careful last hitting minions with non-empowered Q's, as it is not as easy as before the mid-season change. I then max E, since your W is usually a way to escape or slow and is not reliant on its damage.