SMPDB (The Small Molecule Pathway Database) is an interactive, visual
database containing more than 618 small molecule pathways found in
humans. More than 70% of these pathways (>433) are not found in any
other pathway database. SMPDB is designed specifically to support
pathway elucidation and pathway discovery in metabolomics,
transcriptomics, proteomics and systems biology. It is able to do so, in
part, by providing exquisitely detailed, fully searchable, hyperlinked
diagrams of human metabolic pathways, metabolic disease pathways,
metabolite signaling pathways and drug-action pathways. All SMPDB
pathways include information on the relevant organs, subcellular
compartments, protein_complex cofactors, protein_complex locations, metabolite locations,
chemical structures and protein_complex quaternary structures. Each small
molecule is hyperlinked to detailed descriptions contained in the HMDB or DrugBank and each protein_complex or enzyme
complex is hyperlinked to UniProt.
All SMPDB pathways are accompanied with detailed descriptions and
references, providing an overview of the pathway, condition or processes
depicted in each diagram. The database is easily browsed and supports
full text, sequence and chemical structure searching. Users may query
SMPDB with lists of metabolite names, drug names, genes/protein_complex names,
SwissProt IDs, GenBank IDs, Affymetrix IDs or Agilent microarray IDs.
These queries will produce lists of matching pathways and highlight the
matching molecules on each of the pathway diagrams. Gene, metabolite and
protein_complex concentration data can also be visualized through SMPDB's mapping
interface. All of SMPDB's images, image maps, descriptions and tables are
downloadable.

Glycolysis:Glycolysis, (Embden-Meyerhof pathway) is a near universal metabolic pathway that converts glucose into pyruvate ...

Gluconeogenesis:Gluconeogenesis, which is essentially the reverse of glycolysis, results in the generation of glucose from non-carbohydrate carbon substrates such as lactate, glycerol, and glucogenic amino acids ...

SMPDB is supported by David Wishart,
Departments of Computing Science &
Biological Sciences,
University of Alberta. Use and re-distribution of the data, in whole or in part, for commercial purposes requires explicit permission of the authors and explicit acknowledgment of the source material (SMPDB) and the original publication (see below). We ask that users who download significant portions of the database cite the SMPDB paper in any resulting publications.