Research Interests

Research summarySmall for gestational age (SGA) infants are at increased risk of a number of adverse outcomes, including stillbirth, neonatal death, sudden infant death syndrome, cerebral palsy, having a record of special educational needs, and a range of diseases in later life. Some of these adverse outcomes are potentially amenable to intervention. Although a number of serum biomarkers for SGA infants have been identified, the associations are generally too weak to be clinically useful as screening tests in isolation. We aim to study the placenta as a means of identifying novel markers for pathological SGA by comparing transcript profiles in placental samples from SGA infants and matched controls born at term and validating key differentially expressed genes in a separate series of cases and matched controls using qRT-PCR, Western blot and immunohistochemistry.

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