Polo-like Kinases join TLR Viral Detection

Viruses signal their presence to the immune system when they activate membrane and cytosolic receptors. In this issue, Chevrier et al. (pp. 853–867) uncover 35 antiviral signaling regulators, including 19 new members, involved in Toll-like receptor (TLR) pathways. In particular, they find that Polo-like kinases (Plks) are shared components of well-established antiviral pathways. The cover image depicts these antiviral-sensing pathways as a radar system in a dendritic cell that scans for new intruders using intracellular pathways with Plks. Artwork by Sigrid Knemeyer.