The Monster Book of Monsters, by Edwardus Lima, is a particularly vicious textbook that is used in Care of Magical Creatures while Rubeus Hagrid (who thought the book's aggressive nature was funny) was the teacher. The book will attack anyone who attempts to open it. The only way to subdue the book is to stroke its spine, upon which the book opens placidly.

In the film, the Monster Book of Monsters seemed to have a belt given along with it, rather than the students all finding different methods to restrain it.

In the handheld versions of LEGO Harry Potter: Years 1-4, during Year 1, a group of Monster Books attack Flourish and Blotts, and Harry must help assist in restoring some of the other damaged books with the Mending Charm before he can purchase his first year textbooks. Upon leaving the shop, Harry finds that they have escaped out into the main part of the alley, and must destroy them with the Reductor Curse.