Research Disciplines

Research Interests

Structure and assembly of HIV, virus/host interactions, structural biology of the innate immune system

Research Description

Our long-term goals are to understand how proteins interact with each other and how these interactions underlie biological processes. We are particularly interested in molecular and structural switches that control how proteins form high-order quaternary interactions, or macromolecular assemblies. We use X-ray crystallography and cryoEM to determine the structures of individual proteins, protein-protein complexes, and assemblies. To test mechanistic models that arise from these structures, we use biochemical approaches to reconstitute viral and cellular assembly pathways in vitro.