failure

acute kidney failure

acute liver failure

The development of severe liver damage with encephalopathy and jaundice within eight weeks of the onset of liver disease. Coagulopathy, electrolyte imbalance, and cerebral edema are common. Death is likely without liver transplantation. Synonym: fulminant hepatic failure; fulminant hepatitis

Etiology

Symptoms

Early symptoms are often nonspecific and mFay include nausea, vomiting, dizziness, lightheadedness, or drowsiness. As liver injury becomes more obvious, bile permeates the skin, producing jaundice. Alterations in mental status (lethargy or coma) and bleeding caused by coagulopathy may develop.

Diagnosis

The diagnosis is suggested by jaundice and altered mental status in addition to elevations in liver function tests and prolongation of the protime and international normalized ratio (INR).

Patient care

Affected patients should be hospitalized, usually in intensive care under very close monitoring. General patient care concerns apply. Airway support and mechanical ventilation are often needed. Fluids and/or pressors, such as dopamine, may be needed to maintain blood pressure and cardiac output. Nutritional support with a low salt, protein-restricted diet, and most calories supplied by carbohydrates, blood product infusions (fresh frozen plasma and platelets), and lactulose are usually administered. Potassium supplements help to reverse the affects of high aldosterone levels; potassium-sparing diuretics increase urine volume. Ascitic fluid is removed by paracentesis or shunt placement to relieve abdominal discomfort and aid respiratory effort. Portal hypertension requires shunt placement to divert blood flow, and variceal bleeding is treated with vasoconstrictor drugs, balloon tamponade, vitamin K administration, and perhaps surgery (to ligate bleeding portal vein collateral vessels).

Medications that are normally metabolized by the liver and medications that may injure the liver further should be avoided. Patients who have overdosed on acetaminophen may benefit from the administration of acetylcysteine if it can be administered within 12 hr of a single ingestion.

Liver transplantation is the definitive treatment for acute liver failure. Early transplant evaluation should be carried out for every patient for whom there is a donated organ available. Without transplantation, the mortality from acute liver injury may reach 80%.

The patient’s level of consciousness should be assessed frequently, with ongoing orientation to time and place. Girth should be measured daily. Signs of anemia, infection, alkalosis, and GI bleeding should be documented and reported immediately. A quiet atmosphere is provided. Physical restraints are applied as minimally as possible, with chemical restraint prohibited. If the patient is comatose, the eyes are protected from corneal injury using artificial tears and/or eye patches.

The prognosis for the illness should be discussed in a sensitive but forthright fashion and emotional support provided to family members. Agency social workers, the hospital chaplain, and other support personnel should be involved in the patient’s care as appropriate to individual needs.

acute renal failure

Abbreviation: ARF

A sudden, significant decrease in the filtration capabilities of the kidneys and, within hours or days, an increase in the levels of creatinine and other waste products in the systemic circulation. ARF occurs in approximately 5% of all patients admitted to hospitals. It often results from accidents, e.g., severe burns and trauma, that cause large losses in body fluid. A number of drugs can cause ARF. Hospital procedures can also cause ARF, and ARF affects more than 25% of surgical patients who require cardiopulmonary bypass and almost 30% of patients in ICU. When ARF is the result of a decrease in blood volume without kidney damage, the condition can often be quickly and completely reversed. When the kidneys have been injured, however, they must heal if the ARF is to resolve. Synonym: acute kidney failure; acute kidney injurydialysis; table;

Intrarenal: A less common ARF is caused from direct damage to the kidneys. Ninety percent of these cases are caused either by ischemia (from prolonged prerenal ARF or from diseases of blood vessel walls, glomerulonephritis, hyperviscosity syndromes, malignant hypertension, thrombotic microangiopathies, or vasculitis) or by nephrotoxins.

Postrenal: The least common ARF (less than 5% of cases) is caused by urinary obstruction that leads to increased back-pressure in the kidney tubules, which, in turn, decreases the glomerular filtration rate (GFR). Urinary obstruction most often occurs at the bladder neck due to anticholinergic drug therapy, neurogenic bladder, or prostatic disease.

Treatment

Acute renal failure caused by urinary outlet obstruction (postrenal failure) often completely resolves when urinary flow is restored, i.e., after a urinary catheter is placed or a prostatectomy performed. Renal failure caused by prerenal conditions, i.e., from reduced blood flow to the kidneys (as in dehydration or shock), sometimes improves with fluid and pressor support but may require other therapies, including dialysis. The resolution of ARF caused by intrarenal diseases (as in acute tubular necrosis) and kidney toxins depends on the underlying cause and the duration of the exposure. For example, immunosuppressant drugs may reverse ARF due to glomerulonephritis or renal vasculitis whereas forced diuresis is the treatment for those whose disease is caused by rhabdomyolysis.

Patient care

Patients with ARF may stop making urine, have a sudden rise in BUN and creatinine levels, and develop metabolic acidosis and electrolyte imbalances, esp. hyperkalemia. Other complications may follow as uremia develops, e.g., altered mental status, anorexia, arrhythmias, and fluid overload. The specific cause is identified and removed if possible. The nurse instructs the patient about dietary and fluid restrictions and implements these restrictions, promotes infection prevention, and advises the patient about activity restrictions due to metabolic alterations.

Neurological status is assessed, and safety measures are instituted. Intake and output and daily weights (measures of fluid status) are monitored. Daily blood tests determine acid-base and electrolyte balance. Hyperkalemia is treated with dialysis, intravenous hypertonic glucose solutions, insulin infusion, sodium bicarbonate, or potassium exchange resins administered orally or by enema, depending on its severity. The nurse should assess the patient for edema in the legs and feet, hands and sacrum, and around the eyes. It is also usual to record urine color and clarity. The patient is assessed for gastrointestinal (GI) and cutaneous bleeding and anemia; blood components are replaced, or erythropoietin therapy is administered as prescribed. Blood pressure, pulse, respiratory rate, and heart and lung sounds are regularly assessed for evidence of pericarditis or fluid overload. Cardiac monitoring is used to detect changes in cardiac conduction related to hyperkalemia. Anorexia, nausea, and vomiting result from uremia and lead to poor nutrition with loss of body muscle and mass. Nutritional support is critical to combat malnutrition, infection, and to limit electrolyte imbalances. Protein calorie malnutrition is prevalent in ARF. Renal failure diet requires careful management of total calories, protein, electrolytes, minerals, vitamins, and fluid volume. It should provide enough calories (30–35 kcal/kg) through fats and carbohydrates to limit muscle breakdown. At the same time, protein intake should be restricted to about 1.2 to 1.3 g/kg to minimize azotemia. Sodium intake should be limited to 2 to 4 g a day to limit water retention and hypertension. Potassium intake is restricted because, in renal failure, potassium is not excreted by the kidneys, and hyperkalemia may produce muscle weakness and cardiac rhythm disturbances. Oral intake of phosphorus must also be limited as prescribed; alternately, phosphorus-binding medications are taken with meals to prevent hyperphosphatemia. Oral calcium supplements are often used for this purpose. Vitamins B, C, and folate supplements are often given. Fluids are usually limited to the amount of the patient's urine output plus 500 to 700 ml for metabolic needs. Oral hygiene and misting provide relief for dry mucous membranes and help to prevent inflammation and infection. All stools are tested to monitor for GI bleeding. Aseptic technique is used in caring for this patient, who is extremely susceptible to infection. Other therapies include incentive spirometry, coughing, passive range-of-motion exercises, antiembolism stockings or pneumatic leg dressings, and ambulation. Acute renal failure often results in a protracted illness. Many patients with ARF requiring intensive care will die. As a result, the patient and family require continuous emotional support, and education about the treatment regimen (including dialysis if it is employed), nutritional restrictions, and the use of medications. Because some patients will eventually need to have arteriovenous fistula constructed for dialysis, intravenous access should be limited to the dorsal aspects of the hands whenever possible.

If ARF is not reversed but progresses to chronic (end-stage) renal failure, follow-up care with a nephrologist is arranged, and evaluation and teaching are provided for maintenance dialysis and/or possible kidney transplant. Referral is made for vocational or other counseling as needed.

acute respiratory failure

Treatment

In most cases the patient will need supplemental oxygen therapy. Intubation and mechanical ventilation may be needed if the patient cannot oxygenate and ventilate adequately, i.e., if carbon dioxide retention occurs. Treatment depends on the underlying cause of the respiratory failure, e.g., bronchodilators for asthma, antibiotics for pneumonia, diuretics or vasodilators for congestive heart failure.

Patient care

Patients with acute respiratory failure are usually admitted to an acute care unit. The patient is positioned for optimal gas exchange, as well as for comfort. Supplemental oxygen is provided, but patients with chronic obstructive lung disease who retain carbon dioxide are closely monitored for adverse effects. A normothermic state is maintained to reduce the patient's oxygen demand. The patient is monitored closely for signs of respiratory arrest; lung sounds are auscultated and any deterioration in oxygen saturation immediately reported. The patient is also watched for adverse drug effects and treatment complications such as oxygen toxicity and acute respiratory distress syndrome. Vital signs are assessed frequently, and fever, tachycardia, tachypnea or bradypnea, and hypotension are reported. The electrocardiogram is monitored for arrhythmias. Serum electrolyte levels and fluid balance are monitored and steps are taken to correct and prevent imbalances. If mechanical ventilation or noninvasive support is needed, ventilator settings and inspired oxygen concentrations are adjusted based on arterial blood gas results. See: ventilation To maintain a patent airway, the trachea is suctioned after oxygenation as necessary, and humidification is provided to help loosen and liquefy secretions. Secretions are collected as needed for culture and sensitivity testing. Sterile technique during suctioning and change of ventilator tubing helps to prevent infection. Use of the minimal leak technique for endotracheal tube cuff inflation helps prevent tracheal erosion. Positioning the nasoendotracheal tube midline within the nostril, avoiding excessive tube movement, and providing adequate support for ventilator tubing all help to prevent nasal and endotracheal tissue necrosis. Periodically loosening the securing tapes and supports prevents skin irritation and breakdown. The patient is assessed for complications of mechanical ventilation, including reduced cardiac output, pneumothorax or other barotrauma, increased pulmonary vascular resistance, diminished urine output, increased intracranial pressure, and gastrointestinal bleeding.

All tests, procedures, and treatments should be explained to the patient and family to improve understanding and help reduce anxiety. Rationales for such measures should be presented, and concerns elicited and answered. If the patient is intubated (or has had a tracheostomy), the patient should be told why speech is not possible and should be taught how to use alternative methods to communicate needs, wishes, and concerns to health care staff and family members.

adult failure to thrive

A progressive functional deterioration of a physical and cognitive nature. The individual's ability to live with multisystem diseases, cope with ensuing problems, and care for himself are markedly diminished.

failure of artificial pacemaker

A defect in a pacemaker device caused by either a failure to sense the patient's intrinsic beat or a failure to pace. Failure to pace can be caused by a worn-out battery, fracture or displacement of the electrode, or pulse generator defect.

backward heart failure

Heart failure in which blood congests the lungs, and often the right ventricle, liver, and lower extremities.

cardiac failure

chronic respiratory failure

Chronic inability of the respiratory system to maintain the function of oxygenating blood and remove carbon dioxide from the lungs. Many diseases can cause chronic pulmonary insufficiency, including asthmatic airway obstruction, emphysema, chronic bronchitis, and cystic fibrosis; and chronic pulmonary interstitial tissue diseases such as sarcoidosis, pneumoconiosis, idiopathic pulmonary fibrosis, disseminated carcinoma, radiation injury, and leukemia.

Patient care

The focus of patient care is to relieve respiratory symptoms, manage hypoxia, conserve energy, and avoid respiratory irritants and infections. The nurse, respiratory therapist, primary care physician, and pulmonologist carry out the prescribed treatment regimen and teach the patient and family to manage care at home.

Patients may require supplemental oxygen. The patient is taught how to use the equipment and the importance of maintaining an appropriate flow rate. Low flow rates (1–2 L/min) are often best for patients with chronic obstructive lung disease. Drug therapy can include inhaled bronchodilators (if bronchospasm is reversible), oral or inhaled corticosteroids, oral or inhaled sympathomimetics, inhaled mucolytic therapy, and prompt use of oral antibiotics in the presence of respiratory infection. The patient and family are taught the order and spacing for administering these drugs, as well as how to use a metered-dose inhaler (with spacer if necessary). They are taught the desired effects, serious adverse reactions to report, and minor adverse effects and how to deal with them. Patients are taught care of inhalers and other respiratory equipment and are advised to rinse the mouth after using these devices to help limit bad tastes, dryness, and Candida infections.

Unless otherwise restricted, the patient will benefit from increased fluid intake (to 3 L/day) to help liquefy secretions and aid in their expectoration. Deep-breathing and coughing techniques are taught to promote ventilation and remove secretions. The patient also may be taught postural drainage and chest physiotherapy to help mobilize secretions and clear airways. Such therapy is to be carried out at least 1 hr before or after meals. Incentive spirometry may help to promote optimal lung expansion. A high-calorie, high-protein diet, offered as small, frequent meals, helps the patient maintain needed nutrition, while conserving energy and reducing fatigue.

Daily activity is encouraged, alternating with rest to prevent fatigue. Patients may benefit from a planned respiratory rehabilitation program to teach breathing techniques, provide conditioning, and help increase exercise tolerance. Diversional activities also should be provided, based on the patient's interests.

The patient is assessed for changes in baseline respiratory function; restlessness, changes in breath sounds, and tachypnea may signal an exacerbation. Any changes in sputum quality or quantity are noted. The patient is taught to be aware of these changes.

Patients need help in adjusting to lifestyle changes necessitated by this chronic illness. Patients and their families are encouraged to ask questions and voice concerns; answers are provided when possible, and support is given throughout. The patient and family should be included in all care planning and related decisions. The patient also is taught to avoid air pollutants such as automobile exhaust fumes and aerosol sprays, as well as crowds and people with respiratory infections. Patients should obtain influenza immunization annually and pneumonia immunization every 6 years. The patient also may benefit from avoiding exposure to cold air and covering the nose and mouth with a scarf or mask when outdoors in cold, windy weather. Patients who smoke tobacco are advised to abstain, using nicotine replacement therapy, hypnotism, support groups, or other methods.

circulatory failure

Failure of the cardiovascular system to provide body tissues with enough blood for proper functioning. It may be caused by cardiac failure or peripheral circulatory failure, as occurs in shock, in which there is general peripheral vasodilation with pooling of blood in the expanded vascular space, resulting in decreased venous return.

failure of compensation

The inability of the heart muscle or other diseased organs to meet the body's needs. In cardiac failure, this results in pulmonary congestion, difficult breathing, and sometimes hypotension or lower extremity swelling. Causes of cardiac compensatory failure may occur in patients with ischemic heart disease, valvular heart disease, or cardiomyopathies.

congestive heart failure

extubation failure

Respiratory failure after discontinuation of mechanical ventilation, accompanied by the need to reintubate the patient.

forward heart failure

Heart failure in which forward flow of blood to the tissues is inadequate because the left ventricle is unable to pump blood with enough force to the systemic circulation (such as a result of cardiomyopathy, muscular stunning, or infarction) or because outflow from the left ventricle is obstructed as in aortic stenosis).

fulminant hepatic failure

heart failure

Inability of the heart to circulate blood effectively enough to meet the body's metabolic needs. Heart failure may affect the left ventricle, right ventricle, or both. It may result from impaired ejection of blood from the heart during systole or from impaired relaxation of the heart during diastole. In the U.S., about 400,000 people are diagnosed with heart failure each year, and about 10% to 20% of affected persons die of the disease annually. Heart failure is one of the most common causes of hospitalization and rehospitalization in the U.S. The prognosis for patients with heart failure depends on the ejection fraction, that is, the proportion of blood in the ventricle that is propelled from the heart during each contraction. In healthy patients, the ejection fraction equals about 55% to 78%. Synonym: cardiac failure; congestive heart failure See: ejection fraction; pulmonary edema

Diagnosis

Heart failure is easily diagnosed in a patient with typical symptoms and signs, esp. when these findings are accompanied by a chest x-ray that shows an enlarged heart and pulmonary edema. In patients with an uncertain presentation, elevated levels of B-type natriuretic peptide (BNP) may aid in the diagnosis.

Symptoms

Difficulty breathing is the predominant symptom of heart failure. In patients with mild impairments of ejection fraction (45% to 50%), breathing is normal at rest but labored after climbing a flight of stairs or lifting lightweight objects. Patients with advanced heart failure (ejection fraction 20%) may have such difficulty breathing that getting out of bed or taking a few steps is very tiring.

Difficulty breathing while lying flat (orthopnea) or awakening at night with shortness of breath (paroxysmal nocturnal dyspnea) are also hallmarks of heart failure, as are exertional fatigue and lower extremity swelling (edema).

Etiology

Heart failure may result from myocardial infarction, myocardial ischemia, arrhythmias, heart valve lesions, congenital malformation of the heart or great vessels, constrictive pericarditis, cardiomyopathies, or conditions that affect the heart indirectly, including renal failure, fluid overload, thyrotoxicosis, severe anemia, and sepsis. Of the many causes of heart failure, ischemia and infarction are the most common.

Treatment

Diuretics (including furosemide and bumetanide), neurohormonal agents (such as angiotensin-converting enzyme inhibitors or angiotension receptor blockers), beta blockers (such as carvedilol or bisoprolol) are often combined in the acute and chronic treatment of heart failure. Other drugs that have been shown to be effective are nitrates with hydralazine, and aldosterone (a potassium-sparing diuretic). All of these medications must be monitored closely for side effects. In patients with heart failure caused by valvular heart disease, valve replacement surgery may be effective. Cardiac transplantation can be used in advanced heart failure when donor organs are available.

Patient care

In the patient who presents for medical attention in heart failure, signs and symptoms are assessed, and vital signs, cardiac rhythm, and neurological status are closely monitored. A 12-lead ECG is examined for evidence of acute coronary syndromes and cardiac monitoring is instituted. Hemodynamic monitoring is initiated based on the severity of patient symptoms. The chest is auscultated for abnormal heart sounds and for lung crackles or gurgles. Daily weights are obtained to detect fluid retention, and the extremities are inspected for evidence of peripheral edema. If the patient is confined to a bed, the sacral area of the spine is assessed for edema. Fluid intake and output are monitored esp. if the patient is receiving diuretics. Blood urea nitrogen and serum creatinine, potassium, sodium, chloride, and bicarbonate levels are monitored frequently. The complete blood count, liver function tests, thyroid function tests, and kidney functions should be evaluated to determine whether any comorbid conditions such as anemia, nephrotic syndrome, cirrhosis, or hyperthyroidism are contributing to or worsening heart failure. Echocardiography helps measure ejection fraction, a key component in distinguishing between systolic heart failure and diastolic dysfunction. It is also used to estimate ventricular dysfunction, measure intracardiac pressures and wall motion, assess ventricular relaxation and compliance, and demonstrate abnormal chamber sizes, valve deformities, pericardial effusions, and ventricular thrombi. Multiple gated acquisition (MUGA) scans may be used as an alternative. Cardiac catheterization, recommended for patients with angina or large ischemic areas, can exclude coronary artery disease as a cause of HF. Cardiopulmonary exercise testing, employing computers and gas analyzers to determine maximal oxygen consumption, evaluates ventricular performance during exercise. Acceptable total oxygen uptake is 20 ml/kg/m or higher. A result of less than 12 indicates severe HF. Continuous ECG monitoring is provided during acute and advanced disease stages to identify and manage dysrhythmias promptly. The patient's blood pressure and pulse are assessed while the patient is supine, sitting, and standing to detect orthostasis, esp. during diuretic therapy. The legs are assessed for symmetrical pitting edema, a common finding. The patient is placed in high Fowler's position and on prescribed bedrest, and high concentration oxygen is administered as prescribed to ease the patient's breathing. Prescribed medications, such as carvedilol, candesartan, digoxin, furosemide, lisinopril, spironolactone, and potassium, are administered and evaluated for desired responses and any adverse reactions. All patient activities are organized to maximize rest periods. To prevent deep venous thrombosis due to vascular congestion, the caregiver assists with range-of-motion exercises and applies antiembolism stockings or uses heparins or warfarin. Any deterioration in the patient's condition is documented and reported immediately. To help curb fluid overload, the patient should avoid foods high in sodium content, such as canned and commercially prepared foods and dairy products, restricting dietary sodium to 2 to 3 grams a day and fluid intake to 2 liters a day. The importance of regular medical checkups is emphasized, and the patient is advised to notify the health care practitioner if the pulse rate is unusually irregular, falls below 60, or increases above 120, or if the patient experiences palpitations, dizziness, blurred vision, shortness of breath, persistent dry cough, increased fatigue, paroxysmal nocturnal dyspnea, swollen ankles, decreased urine output, or a weight gain of 3 to 5 lb (1.4 to 2.3 kg) in 1 week. Patients and their families and other care givers must understand the action of each of the medications prescribed, along with their possible adverse reactions and actions to be taken if a dose is missed. The importance of renewing prescriptions in a timely manner so that doses are available when needed should be stressed.

Patient activity as tolerated is encouraged with tasks divided into small segments to avoid shortness of breath.

Annual influenza vaccines and a pneumococcal vaccine (repeated every 5 years) help patients minimize the risk of systemic infections. Smokers are encouraged to quit. Frequent rehospitalizations are the rule rather than the exception in heart failure. Effective treatment may depend on a multidisciplinary approach that includes active participation by the patient, the primary care provider and nurse educator, case managers, pharmacists, dietitians, and social workers, among others. Evidence-based clinical pathways for managing heart failure are available from the American Heart Association and other agencies.

high output heart failure

Heart failure that occurs in spite of high cardiac output, for example, in severe anemia, thyrotoxicosis, arteriovenous fistulae, or other diseases.

intestinal failure

An inability to meet the nutritional requirements of the body for growth, development, and homeostasis that results from either a poorly functioning or a surgically-resected intestine. People with intestinal failure require parenteral or enteral nutritional support.

metabolic failure

multiple systems organ failure

multisystem organ failure

organ failure

Inability of one or more of the body's organ systems to perform the tasks of preserving health or homeostasis. The failure may be acute or chronic. Examples include blindness, chronic kidney disease, cirrhosis, dementia, fulminant hepatic failure, hearing loss, heart failure, hypothyroidism, menopause, respiratory failure, and shock.

ovarian failure

Cessation of normal ovarian function, the ability to produce fertilizable eggs when stimulated by gonadotropins.

pump failure

A colloquial term for cardiac failure.

See: cardiac failure

renal failure

Inability of the kidneys to function adequately. It may be partial, temporary, chronic, acute, or complete. Synonym: kidney failure See: end-stage renal disease

respiratory failure

right ventricular heart failure

Failure of the heart to maintain right ventricular output.

failure to thrive

Abbreviation: FTT

A condition in which infants and children not only fail to gain weight but also may lose it, or in which older persons lose the physiological or psychosocial reserves needed to care for themselves. The causes include almost any chronic and debilitating condition.

The retrospective analysis of all patients who were referred to Oregon Health and Science University with a diagnosis of fulminant hepatic failure (FHF) over a 22-month period revealed that 8 of the 20 patients had no apparent explanation for their FHF other than the use of over-the-counter dietary or herbal supplements.

The ELAD(TM) Artificial Liver is designed to provide temporary hepatic replacement therapy for patients with fulminant hepatic failure until their own liver can regenerate or sustain patients until a suitable organ becomes available for transplant.

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