In March 2010, Blue Demon Jr., the president of NWA Mexico, demanded that CMLL (a non-member of NWA Mexico) cease promoting the NWA-branded championships, declaring that all three championships had been vacated as far as the NWA was concerned.[8] NWA Mexico had already tried to reclaim CMLL's three NWA-branded titles on a previous occasion. CMLL ignored both requests; the NWA Welterweight Champion, Mephisto, commented instead that "the titles belong to CMLL", thus the NWA could not vacate them.[9] On August 12, 2010, CMLL unveiled the new NWA World Historic Middleweight Championship to replace the original championship, which it conceded to NWA Mexico.[10] The NWA has not determined a champion since.

Since 1939 45 wrestlers have shared 84 NWA Middleweight Championship reigns. René Guajardo held the championship a record six times. Tarzán López' four reigns totalled 2,948 days, the longest of any champion. The Great Sasuke had the longest single reign, at 1,548 days. Emilio Charles, Jr. had the shortest reign at 11 days.

^ abThe length of Gus Kallio's title reign is too uncertain to calculate.

^ abThe exact date on which Ray Mendoza vacated the championship is unknown, which means the title reign lasted between 7001510000000000000♠51 and 7001810000000000000♠81 days.

^ abThe exact date on which René Guajardo vacated the championship during his sixth reign is unknown, which means the title reign lasted between 7002277000000000000♠277 and 7002538000000000000♠538 days.

^ abThe exact date on which Aníbal vacated the championship during his second reign is unknown, which means the title reign lasted between 7002223000000000000♠223 and 7002253000000000000♠253 days.

^ abThe exact date on which Último Dragon vacated the championship during his first reign is unknown, which means the title reign lasted between 7003115000000000000♠1,150 and 7003151400000000000♠1,514 days.

^ abThe exact date on which Último Dragon vacated the championship during his second reign is unknown, which means the title reign lasted between 7001270000000000000♠27 and 7001570000000000000♠57 days.