1The Russell H. Morgan Department of Radiology & Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 2Graduate School of Biomedical Sciences, University of Texas Southwestern Medical Center, Dallas, TX, United States, 3Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 4Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 5Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 6Physical Medicine and Rehabilitation, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 7Cognitive Science, Johns Hopkins University, Baltimore, MD, United States

Perfusion
imaging plays an important role in management decisions for a variety of
cerebrovascular diseases. Most clinical perfusion MRI of stroke requires the
use of contrast agent. However, contrast-agent perfusion cannot be used or
fails to be used in 10-20% of patients. Therefore, an alternative technique to
Gd-perfusion will benefit a substantial number of patients in clinical
practice. Recently, a MR-Fingerprinting (MRF) ASL was developed for
simultaneous estimations of CBF and bolus timing. In this study, we demonstrated
the clinical utility of MRF-ASL in two types of cerebrovascular diseases,
ischemic stroke and Moyamoya disease.

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