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The missile launcher is a very powerful weapon, able to kill groups of weaker enemies or take down a strong enemy with one shot. The missile launcher, like the Fat Man, is considered both a heavy weapon and an explosive weapon, so the related perks and bobblehead perk will stack. If the player has maxed both the Heavy Gunner and Demolition Expert perks, along with having obtained the Explosives bobblehead, the missile launcher can deal up to 651 damage per shot.

When the weapon is equipped with the targeting computer modification, a red diamond will appear above the target when it is locked onto a target within its range.

When fully modified, its weight can exceed 45 pounds making it one of the heaviest weapons in the game (even exceeding the Fat Man).

Oddly, a missile fired from a missile launcher only inflicts as much damage as a simple frag grenade unless both the Heavy Gunner and Demolition Expert are invested in.

One can be found near Diamond City, in the back of a truck as a trap, next to Back Street Apparel, close to the location of the chem ambush part of the quest Diamond City Blues. This missile launcher will respawn every 24 hours until Back Street Apparel is cleared. This trap also has the potential to spawn a launcher with various attachments/mods to include all three of the highest level upgrades.

Further down the same road between Back Street Apparel and Charles View Amphitheater, a lone super mutant will be patrolling a pedestrian overpass with three meat bags suspended from it. This super mutant will always have a missile launcher.

The Castle (it can be picked up by a Minuteman if the Sole Survivor doesn't get there fast enough during related quests).

Critical hits only affect the direct-hit damage of the weapon, not the explosive component, making them significantly weaker than one would expect. The same goes for many legendary effects.

VATS mode does not take the targeting computer mod into account when calculating the accuracy of aimed shots. Regardless of the numbers, a VATS shot on a target you have locked on will have 100% accuracy unless there is intervening terrain.

So far it is one of the only incarnations of the missile launcher across the entire Fallout franchise that can actively utilize a functional missile guidance system outside of V.A.T.S., provided the targeting computer mod is installed.

This incarnation is notably simpler and less bulky than in previous installments.

The triple barrel modification doesn't actually add extra barrels to the weapon but gives the missile launcher a 3 round detachable magazine and also improves the weapon's reload speed but at the cost of substantially increasing its weight.

In the loading screen that features the missile launcher it is shown with both a telescopic sight and a targeting computer. However, this is a configuration that is currently impossible to implement in the game due to the fact that the targeting computer is considered a sight modification and since both modifications are considered sights either one or the other can be installed but not both.