Could not load file or assembly 'App_Web_xxxxxxxx, Version=0.0.0.0, Culture=neutral, PublicKeyToken=null' or one of its dependencies. The system cannot find the file specified.

Solution :-

Both errors appear in ASP.NET application from time to time. There are some info about master pages, nested user controls related to this stuff. And hotfix from MS, usually. Not sure that hotifx helps, but you can try. Anyway, this error last till application automatic rebuild. So, you can just reupload/change some files of your project, and force rebuild. There are some notices that this error can occur weekly or even daily. Restart app every day is not looks good. Bad news. Avoid of master pages and user controls usage - is a bad idea.

But immediate cause of this - incorrect automatic compiler work. So, to correct this error on production hosting, you can use precompiling.

Let's start. First of all, locate this utility C:\WINDOWS\Microsoft.NET\Framework\v2.0.50727\aspnet_compiler.exe (your path can be different because of windows directory). After that create a cmd-file with following content:

Some descriptions regarding this line: -p sets physical path to your web site source -v sets virtual directory where you want to publish your site ( / set the root of virtual directory, 99% that you don't need to change this ) -fixednames binaries will be given fixed names

I'm suggest that this should be used only for production hosting, because in case of frequent updates... not very comfortable to work through build.