Current Medical MycologyCurrent Medical MycologyCurr Med MycolMedical Scienceshttp://cmm.mazums.ac.ir1admin2423-34392423-342010.29252/cmmenjalali139791gregorian201812144online1fulltextenPrevalence of specific immunoglobulin E and G against Aspergillus fumigatus in patients with asthmaقارچ شناسی پزشکیMedical MycologyپژوهشيOriginal Articles<strong>Background and Purpose:</strong> Aspergillus fumigatus as a ubiquitous fungus can be found in the respiratory tract of the asthmatic and healthy people. The inhalation of Aspergillus spores leads to an immune response in individuals with asthma and results in the aggravation of the clinical symptoms. The present study aimed to investigate the prevalence of specific immunoglobulin E and G (IgE and IgG) against A.fumigatus in asthmatic patients.<br>
<strong>Materials and Methods:</strong> This study was conducted on 200 consecutive patients with moderate to severe asthma referring to Masih Daneshvari hospital Tehran, Iran, from January 2016 to February 2018. Skin prick test (SPT) was performed in all subjects with Aspergillus allergens. Moreover, all patients underwent specific IgE testing for Aspergillus using Hycor method. Enzyme immune assay was applied to measure total IgE and Aspergillus-specific IgG. <strong>Results:</strong> According to the results, the mean age of the patients was 45.8 years (age range: 18-78 years). The mean levels of total IgE and Aspergillus specific IgE in asthmatic patients were obtained as 316.3 (range: 6-1300 IU/ml) and 1.5 (range: 0.1- 61.3 IU/ml), respectively. Out of 200 patients, 27 (13.5%), 65 (32.5%), 22 (11.0%), and 86 (43.0%) cases had positive Aspergillus SPT, total IgE of > 417 IU/ml, Aspergillus-specific IgE, and IgG, respectively. The level of these variables in patients with severe asthma were 16 (16.5%), 36 (37.1%), 15 (15.5%), and 46 (47.4%), respectively. <strong>Conclusion:</strong> As the findings indicated, reactivity to Aspergillus is a remarkable phenomenon in asthmatic patients. It is also emphasised that the climatic condition may affect the positive rate of hypersensitivity to Aspergillus.&nbsp; Aspergillus fumigatus, Asthmatic patients, Specific IgE, Specific IgG711http://cmm.mazums.ac.ir/browse.php?a_code=A-10-27-4&slc_lang=en&sid=1NewshaHedayatihedayati.newsha@gmail.com1003194753284600540210031947532846005402NoStudent Research Committee, Mazandaran University of Medical Sciences, Sari, IranVidaMortezaeeVidamortezaee@gmail.com1003194753284600540310031947532846005403NoStudent Research Committee, Invasive Fungi Research Center, Mazandaran University of Medical Sciences, Sari, Iran.Seyed AlirezaMahdavianimahdavini@yahoo.com1003194753284600540410031947532846005404NoPediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, IranMaryam SadatMirenayatmirenayat_m@yahoo.com1003194753284600540510031947532846005405NoChronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NIRTLD), Shahid Beheshti University of Medical Sciences, Tehran, IranMaryamHassanzadmar_hassanzad@yahoo.com1003194753284600540610031947532846005406NoPediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, IranMihanPourabdollahmihan_p@yahoo.com1003194753284600540710031947532846005407NoPediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, IranJalalHeshmatniajalalheshmatnia@gmail.com1003194753284600540810031947532846005408NoChronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NIRTLD), Shahid Beheshti University of Medical Sciences, Tehran, IranAtefehFakharianfakharian_2005@yahoo.com1003194753284600540910031947532846005409NoChronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NIRTLD), Shahid Beheshti University of Medical Sciences, Tehran, IranGuittiPourdolatpurdowlat_g@yahoo.com1003194753284600541010031947532846005410NoChronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NIRTLD), Shahid Beheshti University of Medical Sciences, Tehran, IranSomayehSharifyniasharifynias@gmail.com1003194753284600541110031947532846005411NoClinical Tuberculosis and Epidemiology Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, IranMahshidVakilimahshid.vakili2011@gmail.com1003194753284600541210031947532846005412NoStudent Research Committee, Mazandaran University of Medical Sciences, Sari, Iran.MahdiAbastabarmabastabar@gmail.com1003194753284600541310031947532846005413NoInvasive fungi research center, Mazandaran University of Medical Sciences, Sari, IranImanHaghani1003194753284600541410031947532846005414NoMasoudAliyali1003194753284600541510031947532846005415NoHosseinAsgarian-OmranAsgarian@gmail.com1003194753284600541610031947532846005416NoDepartment of Immunology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.Mohammad T.Hedayatihedayatimt@gmail.com1003194753284600541710031947532846005417Yes
Invasive fungi research center, Mazandaran University of Medical Sciences, Sari, Iran