Recently I've read a number of studies that discuss Ki-67 as an independent variable with prognosis and direction of tx. I don't see many people that include that information in their signature line. Donna, I know that you do.

Mine was pretty high 85%. I was just curious if anyone else was willing to share that info.

bjoangtx,As you can see from my signature line, my KI-67 at the time of biopsy was 86% and 3 weeks later the results from the bi-lateral mastectomy showed a KI-67 of 99%. It will be 3 years in March since my diagnosis and so far I show NED (no evidence of disease). I feel very blessed!

My path report showed >20% then in the body of the report it said "Since more than 20% of tumor cells are actively cycling (in the G1, S, G2 and M phases of the cell cycle), this tumor is considered to have a HIGH PROLIFERATION RATE."

I believe the higher the number the faster the cells are dividing, ie, Grade 3. For what it's worth, mine was 48% and I had a recurrence. I've seen other women with KI-67 in the 90's that are NED many years later.

Tags:

PURPOSE: Recently, Ki67 index (cell proliferation marker) has been attracting a considerable attention as a prognostic factor in breast cancer but the prognostic significance of Ki67 after neoadjuvant chemotherapy (NAC) has rarely been examined. EXPERIMENTAL DESIGN: Primary breast cancer patients (n = 102) treated with NAC (sequential paclitaxel 12 cycles (q1w) and 5-FU/epirubicin/cyclophosphamide 4 cycles (q3w)) were recruited in the study. Ki67, estrogen receptor (ER) and progesterone receptor (PR) and breast cancer resistant protein (BCRP) and P-glycoprotein were determined by immunohistochemistry and HER2 was determined by FISH in tumor tissues obtained before and after NAC, and their association with patient prognosis (relapse-free survival) was examined. RESULTS: Of the 102 patients, pCR was achieved in 30 (29.4%). In the 72 non-pCR patients, Ki67 index significantly (P < 0.001) decreased after NAC. Ki67 index after NAC, but not Ki67 index before NAC, was significantly associated with a patient prognosis (P = 0.022). Multivariate analysis has shown that Ki67 index after NAC is a marginally significant (P = 0.05) prognostic factor and that other biomarkers including ER, PR, BCRP, and P-glycoprotein before and after NAC are not significant. CONCLUSIONS: Ki67 after NAC, but not before NAC, is prognostic in breast cancer patients, and might be clinically useful in the prognosis prediction of patients who do not achieve pCR after NAC. On the other hand, BCRP and P-glycoprotein before and after NAC are unlikely to be useful as prognostic factors in these patients.

I can't get my hands on the original biopsy report at the moment, but my recollection is that prior to chemo, it was around 90%. After chemo at the time of surgery, it was 13% (the path report says "borderline").

Actually from what I've read if there is a drop in the Ki-67 in response to treatment that's a good sign. Mine didn't change. It was 85% at biopsy and 85% after chemo. The fact that yours went down to 13% is a positive sign.

I was told this test could only be done when the original tumor was removed, biopsied or surgery. As it tells the speed the tumor is dividing. My Onc told me he cannot run the test after the tumor has been removed. Of course, new tumors or mets would allow for the test to be redone. Not the same as the cancer marker blood tests

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