Prior to Voyager, Biller was a writer and executive story editor on the popular series Beverly Hills, 90210. During his tenure on this series, Biller, in collaboration with Chris Brancato, penned the episode "Wild Horses", which guest-starred Alice Krige. Biller also co-wrote the 1993 X-Files episode "Eve" and wrote the 1999 TV movie The Last Man on Planet Earth for director Les Landau.

After Voyager, Biller became Co-Executive Producer, Writer and Director on the television shows Dark Angel, Smallville, and North Shore. He also executive produced, wrote and directed for the NBC series E-Ring. In 2008, Biller directed an episode of Smallville that featured Voyager regular Robert Picardo.