Role of Epicardial Adipose Tissue in Coronary Artery Disease

Summary

We sight to evaluate whether patients with coronary artery disease (CAD) have more
epicardial fat than patients without CAD, which would suggest that epicardial fat may be
more than an “innocent bystander” and be actively involved in the disease process. Its role
as a modulator of vascular response and myocardial function could potentially lead to new
areas of cardiac research. We also sight to evaluate whether epicardial fat from patients
with CAD releases more adipokines than subcutaneous fat from these patients which could
prompt studies into the differential regulation of adipokine secretion in this tissue. Thus
for e.g., the use of thiazolidinediones (glitazones), statins, ARBs or other compounds that
can specifically modulate adipokine secretion could be explored to determine their benefit
in ameliorating the effects attributable to increased epicardial fat.

Coronary artery anomalies are often discovered incidentally during cardiac catheterization or computed tomography coronary angiography and may involve the affected coronary artery origin and its cours...

Left main coronary artery disease is found in 4-6% of patients undergoing diagnostic coronary angiography. Coronary artery bypass graft is the gold standard. However, percutaneous coronary interventio...

Sudden cardiac death is a major public health issue, with high incidence and disappointing survival. Therefore, prevention of sudden death and identification of high-risk patients are essential tools,...

To evaluate the relationship between an incremental model including cardiovascular risk factors, carotid disease, and inflammatory biomarkers to predict the presence of obstructive coronary artery dis...

Medical and Biotech [MESH] Definitions

Coronary Artery Bypass

Surgical therapy of ischemic coronary artery disease achieved by grafting a section of saphenous vein, internal mammary artery, or other substitute between the aorta and the obstructed coronary artery distal to the obstructive lesion.

Internal Mammary-coronary Artery Anastomosis

Direct myocardial revascularization in which the internal mammary artery is anastomosed to the right coronary artery, circumflex artery, or anterior descending coronary artery. The internal mammary artery is the most frequent choice, especially for a single graft, for coronary artery bypass surgery.

Coronary-subclavian Steal Syndrome

A complication of INTERNAL MAMMARY-CORONARY ARTERY ANASTOMOSIS whereby an occlusion or stenosis of the proximal SUBCLAVIAN ARTERY causes a reversal of the blood flow away from the CORONARY CIRCULATION, through the grafted INTERNAL MAMMARY ARTERY (internal thoracic artery), and back to the distal subclavian distribution.

Coronary Artery Disease

Pathological processes of CORONARY ARTERIES that may derive from a congenital abnormality, atherosclerotic, or non-atherosclerotic cause.

Gastroepiploic Artery

Abdominal artery that follows the curvature of the stomach. The right gastroepiploic artery is frequently used in CORONARY ARTERY BYPASS GRAFTING; MYOCARDIAL REVASCULARIZATION, and other vascular reconstruction.

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