Detailed molecular knowledge of the complex dynamics of biological processes such as folding and the interaction with cellular membranes may greatly advance the treatment of human disease. The Neuropeptide Y family of ...

Gamma Hydroxybutyrate (GHB) is an endogenous metabolite of gamma-aminobutyric acid (GABA) and a putative neurotransmitter found in mammalian brain. The illicit use of GHB is a growing health care concern in the U.S. Low ...

Blood monocytes from SLE patients display DC function, as they are able to induce the proliferation of allogeneic T cells. Furthermore, sera from SLE patients induce healthy monocytes to differentiate into DCs. This ...

Critical to the development of human vaccines is the availability of in vivo models of the human immune system that permit testing of vaccine efficacy. Here,we used NOD-SCID-β²m-/- immunodeficient mice which, when engrafted ...

Inhibitors of β-lactamases are important to the treatment of infectious diseases when used in conjunction with a β-lactam antibiotic. Current inhibitors of β-lactamase such as clavulanic acid, sulbactam, and tazobactam ...

Contaminants of emerging concern (CEC) are classes of compounds with relatively limited information available on environmental exposure, fate, and effects. The purpose of this research was to develop and test approaches ...

The amygdala has been shown to be involved in both epilepsy and emotional disturbances such as in mood and anxiety disorders. It is suggested that anxiety and mood disorders may be the result of sub-seizure hyperexcitability ...

Colorectal cancer (CRC) is the second leading cause of cancer-related deaths in
the United States. An estimated over 140,000 people will be diagnosed with CRC and
over 50,000 people will die in 2013. CRC tumors develop ...

Allergic disease causes much distress within industrialized areas of the world, affecting approximately a quarter of the population in such areas. Current immunotherapy involves the administration of increasing concentrations ...

Cyclin B1 is a cell cycle regulatory protein aberrantly overexpressed in a number of cancers, including breast cancer. While the current standards of care for breast cancer are sometimes curative, many patients suffer ...

Breast cancer is the most common cancer among American women. The current therapies are not curative for some forms of breast cancer, especially breast cancers that do not express the growth factor and hormone receptors ...

Dendritic cells have the ability to control the balance between immunity and tolerance. Upon viral exposure, Dendritic Cells (DCs) steadily detect pathogens and exert their antigen presentation function to induce adaptive ...

The intercellular and intracellular signaling pathways elucidated through research on the nematode C. elegans provide valuable information on the communication systems throughout all organisms. Through the use of RNA ...

We present a study of structural analysis and reorientational dynamics of the angiotensin family of peptides. AngI is a decapeptide that acts as a precursor to the octapeptide, AngII in the Renin Angiotensin Aldosterone ...

In tumor microenvironment, the crosstalk between infiltrating inflammatory cells and tumor cells creates a cytokine milieu which can promote both oncogenesis and tumor rejection. We have found an IL-13 dominant cytokine ...

The β-amino acid taurine, whose primary physiological roles involve osmoregulation and calcium modulation, exists as one of the most concentrated amino acids in the mammalian brain. As a neuroinhibitor and neuromodulator, ...