ADC Summit 2014

19th May to 20th May 2014,
London, United Kingdom

Antibody Drug Conjugates (ADCs) offer the promise and potential of delivering powerful tumour-killing activity with the advantage of reduced side effects for cancer patients. While one of the biggest challenges in manufacturing these powerful ADCs is controlling all the components that go into the final conjugation step, researchers do believe that further improvements and research in ADC design can and are resulting in a new generation of agents.

Following on from the success of past events,SMI are proud to present 3rd annual Antibody Drug Conjugates Summit, 19th-20th May 2014, London. Focusing on innovative manufacturing techniques, preclinical and clinical data and next generation ADCs, this important and timely meeting will bring together key industry experts from academia and large and small pharma and biotech companies.

Join us and hear case studies, presentations and round tables demonstrating how to maximise the therapeutic index of your ADC and how this form of empowered antibody is transforming next-generation antibody therapeutics. This must attend event will be delivered by true industry experts who will inform you of latest developments.

This 2 day networking event will invite in depth discussion of key drivers impacting ADCs, providing a fantastic opportunity to hear from and talk to professionals currently operating in the market. Join the event of the year to:

• Hear cutting edge presentations and key case studies from leading ADCs experts
• Network and learn from industry and academic opinion leaders
• Learn about latest developments pertaining to the components of ADCs (payload, antibody and linker)
• Discover what is happening with next generation ADCs

8:30 Registration & Coffee

9:00 Chairman's Opening Remarks

9:10 The development of nanobodies and their potential use for ADC

• An update on the nanobody platform
• Discussing the advantages for ADC

9:50 Exploring nano-delivery systems for antibody delivery

Katherine Vallis, Professor of Experimental Radiotherapeutics, University of Oxford

• Learning about the emerging applications of nanotechnologies in ADC.
• Understanding how nanotechnology is at the leading edge of cancer drug delivery due to its emerging features of:
o controlled release
o antibody-driven specificity

10:30 Morning Coffee

• Site-specific conjugation to disulfide bonds of antibodies and antibody fragments reduces ADC heterogeneity
• ThioBridge™ linkers provide stable conjugates and can be used with a variety of payloads
• ThioBridge™ technology can be used to create novel ADC formats
• In vitro and in vivo data demonstrates good efficacy for mAb and Fab conjugates with an established payload

11:30 Working in perfect harmony - selecting the right target and the right antibody

Adeela Kamal, Associate Director, Medimmune Inc

• Understanding lessons learned from target identification and validation
• Realizing the importance of target expression and internalization
• Reviewing approaches to select a lead ADC: a case study

12:10 Networking Lunch

13:10 Antibody fragment ADCs

Mahendra Deonarain, CSO, Photobiotics

• Use of engineered single-chain Fvs
• Light-activated and other payloads
• Comparison with whole antibodies

13:50 Creating effective strategies to reduce toxicity

John Flygare, Project Leader, Discovery Chemistry, Genentech Inc

• Utilizing novel linkers and payloads to improve therapeutic index
• Examining ways to overcome the resistance developed in clinical ADCs
• Using site specific antibody modifications to improve efficacy

10:30 Morning Coffee

• Cell–free protein synthesis methods have been developed for production of homogeneous therapeutic proteins, including ADCs
• Many variants can be expressed in hours and rapidly assessed for function. Within days, production of chosen variants can be scaled using the same platform to generate material for clinical studies.
• The power and utility of the platform to design and manufacture single species bispecific and multispecific antigen-targeted antibodies with conjugated combination warheads will be described

Interview with Polytherics

Interview with Photobiotics

Holiday Inn Kensington Forum

97 Cromwell Road
London SW7 4DN
United Kingdom

Holiday Inn Kensington Forum is perfectly situated in one of London’s most luxurious and beautiful areas within South Kensington.

The hotel is just 2 minutes walk from Gloucester Road tube station for convenient travel to Hyde Park, London Eye, Tower Bridge plus more of London’s top attractions. There are also easy and direct links to some major transport hubs including Victoria, Kings Cross St Pancras, Paddington and Heathrow.

This distinctive hotel in south London has so much to offer to make all guests really feel at home. The latest Holiday Inn relaunch is not just about the new look and feel for the hotel but to offer guests more benefits during their stay including a pillow menu for extra comfort during their sleep and a curved shower rail for more spacious feel.

In addition to our 906 rooms, all business guests can take advantage of our meeting and conference facilities including High Speed Internet Access and unlimited Starbucks coffee at The Academy. Our hotel’s professional event planners are on board to help take the hard work and stress away from planning your next event.

So whether you in London on business or pleasure, make the Holiday Inn London Kensington Forum your first choice of hotel and book your accommodation for our lowest internet rate guarantee.

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WHAT IS CPD?

CPD stands for Continuing Professional Development’. It is essentially a philosophy,
which maintains that in order to be effective, learning should be organised and
structured. The most common definition is:

‘A commitment to structured skills and knowledge enhancement for Personal or Professional
competence’

CPD is a common requirement of individual membership with professional bodies and
Institutes. Increasingly, employers also expect their staff to undertake regular
CPD activities.

Undertaken over a period of time, CPD ensures that educational qualifications do
not become obsolete, and allows for best practice and professional standards to
be upheld.

CPD can be undertaken through a variety of learning activities including instructor
led training courses, seminars and conferences, e:learning modules or structured
reading.

CPD AND PROFESSIONAL INSTITUTES

There are approximately 470 institutes in the UK across all industry sectors, with
a collective membership of circa 4 million professionals, and they all expect their
members to undertake CPD.

For some institutes undertaking CPD is mandatory e.g. accountancy and law, and linked
to a licence to practice, for others it’s obligatory. By ensuring that their members
undertake CPD, the professional bodies seek to ensure that professional standards,
legislative awareness and ethical practices are maintained.

CPD Schemes often run over the period of a year and the institutes generally provide
online tools for their members to record and reflect on their CPD activities.

TYPICAL CPD SCHEMES AND RECORDING OF CPD (CPD points and hours)

Professional bodies and Institutes CPD schemes are either structured as ‘Input’
or ‘Output’ based.

‘Input’ based schemes list a precise number of CPD hours that individuals must achieve
within a given time period. These schemes can also use different ‘currencies’ such
as points, merits, units or credits, where an individual must accumulate the number
required. These currencies are usually based on time i.e. 1 CPD point = 1 hour of
learning.

‘Output’ based schemes are learner centred. They require individuals to set learning
goals that align to professional competencies, or personal development objectives.
These schemes also list different ways to achieve the learning goals e.g. training
courses, seminars or e:learning, which enables an individual to complete their CPD
through their preferred mode of learning.

As a formal provider of CPD certified activities, SMI Group can provide an indication
of the learning benefit gained and the typical completion. However, it is ultimately
the responsibility of the delegate to evaluate their learning, and record it correctly
in line with their professional body’s or employers requirements.

GLOBAL CPD

Increasingly, international and emerging markets are ‘professionalising’ their workforces
and looking to the UK to benchmark educational standards. The undertaking of CPD
is now increasingly expected of any individual employed within today’s global marketplace.

CPD Certificates

We can provide a certificate for all our accredited events. To request a CPD certificate for a conference , workshop, master classes you have attended please email events@smi-online.co.uk