For known VIMPAT AEs (oral hypoesthesia, dizziness, abnormal dreams, and euphoria), incidences were comparable or lower for 600 mg ADS-4101 versus 400 mg VIMPAT, and the number of subjects with these AEs were small ( Syndigate.

The predominant manifestation of trigeminal nerve affection were mainly sensory manifestations in the form of hypoesthesia of face in 3 patients, anaesthesia of face in 3 patients, and loss of corneal reflexes in 6 patients.

Hypoesthesia or hypoalgesia in the affected trigeminal region always indicates axonal damage and therefore trigeminal neuropathy, while hyperalgesia in the painful region should not immediately lead to the diagnosis of trigeminal neuropathy because it may reflect increased attention to the painful side (4).

He also had mid-systolic click murmur through heart auscultation, bilateral clear breathing sounds, and diminished pulse of the bilateral femoral artery, hypoesthesia below the T3 dermatome, poor joint position but no rigidity or spasticity.

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