Biotechnology News

First EPA-approved outdoor field trial for genetically engineered algae

(Nanowerk News) Scientists at the University of California San Diego and Sapphire Energy have successfully completed the first outdoor field trial sanctioned by the U.S. Environmental Protection Agency for genetically engineered algae.

"Just as agricultural experts for decades have used targeted genetic engineering to produce robust food crops that provide human food security, this study is the first step to demonstrate that we can do the same with genetically engineered algae," said Stephen Mayfield, a professor of biology and an algae geneticist at UC San Diego.

Under the EPA's purview over a 50-day experiment, the scientists cultured strains of the algae species Acutodesmus dimorphus--genetically engineered with genes for fatty acid biosynthesis and green fluorescent protein expression--in parallel with non-engineered algal species. Testing both algae strains in water samples taken from five regional lakes showed strikingly similar levels of growth in the tests, and that the genetic modification did not change the impact of the cultivated strains on native algae communities.

"This study showed the framework for how this type of testing can be done in the future," said study coauthor Jonathan Shurin, an ecologist in UC San Diego's Division of Biological Sciences. "If we are going to maintain our standard of living in the future we are going to need sustainable food and energy, and ways of making those that do not disrupt the environment. Molecular biology and biotechnology are powerful tools to help us achieve that. Our experiment was a first-step towards an evidence-based evaluation of genetically engineered algae and their benefits and environmental risks."

"Progress made in the lab means little if you can't reproduce the phenotype in a production setting," said Shawn Szyjka, the study's lead author, formerly of Sapphire Energy.

Future testing will include additional gene types in experiments that run several months, allowing the researchers to further evaluate influences from weather, seasonal shifts and other environmental factors.

"Algae biomass can address many needs that are key to a sustainable future," said Mayfield, director of the California Center for Algae Biotechnology and the Food and Fuel for the 21st Century initiative. "This is the first of many studies testing this technology in field settings."