Following their defeat at the Battle of Canary Wharf, the Cult of Skaro travelled back to 1930Manhattan. Using Mr Diagoras as their proxy, they began kidnapping humans as test subjects. Upon capture each human was given an intelligence test, humans with low intelligence became pig slaves used only for manual labour, while humans with superior intelligence were to become part of the final experiment. The study of the Final Experiment was to create a new Dalek race born from the combination of Human and Dalek DNA, a human-Dalek hybrid.

It was headed by Dalek Sec, who also served as the subject. Sec had developed a begrudging respect for humanity calling them the ultimate survivors. Dalek Sec hoped that by combining humans and Daleks, the Daleks would inherit humanity's innate talent for survival. The other members of the Cult of Skaro objected to the final experiment as it went against Dalek ideology. Sec argued that the Dalek concept of purity was flawed, as it had brought their species to the brink of extinction. He bonded with Mr Diagoras and through a "chromatid solution", the final outcome was the Human-Dalek. (TV: Daleks in Manhattan)

The Cult succeeded in transforming Dalek Sec into a Human-Dalek hybrid but with unforeseen consequences. Being part human, Sec was able to feel human emotions like sorrow and mercy. Originally Sec had intended to transform every human (with high intelligence) into a hybrid like himself, and for the Earth to become the new Skaro. The hybrids were to be made from humans with above average intelligence who had been captured and had their minds wiped, ready to be programmed with the emotionless Dalek way of thinking. The impact of these new emotions caused Sec to abandon his plan. He appealed to the Doctor for help, asking him to take the Cult of Skaro to a new world. One where they could rebuild their civilisation without the hatred and prejudice of the original Daleks. This plan would have worked by having them become like the new Dalek Sec, and have human emotions but a Dalek brain. Unfortunately, the rest of the Cult no longer saw Sec as being a true Dalek and so betrayed him. The Tenth Doctor considered the failure of the final experiment to be a tragedy. (TV: Evolution of the Daleks)