Application Information: Ankyrin 1 / ANK1 antibody, C-term

0.5
mg/ml
(Please refer to the vial label for the specific concentration)

Purification

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.

Specifications: Ankyrin 1 / ANK1 antibody, C-term

Full Name

ankyrin 1, erythrocytic

Product Description

Goat polyclonal antibody to Ankyrin 1 / ANK1

Background

Attaches integral membrane proteins to cytoskeletal elements; binds to the erythrocyte membrane protein band 4.2, to Na-K ATPase, to the lymphocyte membrane protein GP85, and to the cytoskeletal proteins fodrin, tubulin, vimentin and desmin. Erythrocyte ankyrins also link spectrin (beta chain) to the cytoplasmic domain of the erythrocytes anion exchange protein; they retain most or all of these binding functions. Isoform Mu17 together with obscurin in skeletal muscle may provide a molecular link between the sarcoplasmic reticulum and myofibrils.

Probably the other erythrocyte (Er) isoforms, are located near the surface of erythrocytic plasma membrane. Colocalizes with OBSCN isoform 3/obscurin at the M line in differentiated skeletal muscle cells.