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Most dogs infected with heartworms do not show any signs for a long time. Eventually, as the disease progresses, the animal may exhibit such signs as coughing, weakness, shortness of breath, and exercise intolerance. The signs depend on the number of adult heartworms present, the location of the worms, and the length of time the worms have been present. Infected cats may be asymptomatic or may exhibit signs of respiratory distress, such as coughing or wheezing.