Yeah, given Arrow's success with adapting some outside DC characters into its show, I would expect it too. I just hope they're not TOO adapted. After the MCU showed its ability to stick pretty closely to the comic book looks for its main heroes, it would be sad if the cameos in this show were all Arrow-ized.

I will be totally shocked if we do not get a good amount of references and appearances from the larger Marvel Universe. It seems like we will be following a group of largely made up SHIELD agents, but I believe that a lot of the interactions will be with established characters. I could see Hyrda and AIM playing a large roles and my guess is we will be introduced to a fair amount of street-level superheroes.