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Description

This is the first comprehensive review of mRNA stability and its implications for regulation of gene expression. Written by experts in the field, Control of Messenger RNA Stability serves both as a reference for specialists in regulation of mRNA stability and as a general introduction for a broader community of scientists.

Key Features

Provides perspectives from both prokaryotic and eukaryotic systems

Offers a timely, comprehensive review of mRNA degradation, its regulation, and its significance in the control of gene expression

Discusses the mechanisms, RNA structural determinants, and cellular factors that control mRNA degradation

Evaluates experimental procedures for studying mRNA degradation

Table of Contents

Prokaryotes. Mrna Degradation in Prokaryotic Cells: An Overview. The Role of the 3' End in Mrna Stability and Decay. 5'mrna Stabilizers. RNA Processing and Degradation By Rnase E and Rnase K. RNA Processing and Degradation By Rnase III. Translation and Mrna Stability in Bacteria: A Complex Relationship. Eukaryotes. Mrna Degradation in Eukaryotic Cells: An Overview. Hormonal and Developmental Regulation of Mrna Turnover. Control of the Decay of Labile Proto-Oncogene and Cytokine Mrnas. Translationally Coupled Degradation of Tubulin Mrna . Iron Regulation of Tranferrin Receptor Mrna Stability. Degradation of a Non-Polyadenylated Messenge: Histone Mrna Decay. Mrna Turnover in Saccharomyces Cerevisiae. Control of Mrna Degradation in Organelles. Control of Poly(A) Length. Mrna Decay in Cell-Free Systems. Eukaryotic Nucleases and Mrna Turnover. Experimental Approaches to the Study of Mrna Decay. Subject Index.

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