Conventional localized 1H MRS pulse
sequences, such as PRESS and STEAM, generally suffer from J coupling modulations which can aggravate attenuation of multiplet
resonances during echo times. Here, the “perfect echo” module combined with an optimized
localization scheme is utilized for in-phase single-voxel in vivo MRS at 9.4 T.
The relative signal intensities of multiplet to singlet resonances acquired at
short and moderate echo times increase substantially in comparison with those at
PRESS spectra. Therefore, direct MRS quantification of many important
metabolites, such as glutamine, glutamate, γ-aminobutyrate, aspartate, and
myo-inositol, may be improved.

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