Verknüpfte Pathways mit ITK Proteine

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Mouse (Murine) IL2-Inducible T-Cell Kinase (ITK) Interaktionspartner

Our results provide new insight into the effect of ITK and suboptimal T-cell receptor signaling on CD8 (zeige CD8A Proteine)(+) T cell function, and how these may contribute to phenotypes associated with ITK deficiency

Human IL2-Inducible T-Cell Kinase (ITK) Interaktionspartner

Our results provide new insight into the effect of ITK and suboptimal T-cell receptor signaling on CD8 (zeige CD8A Proteine)(+) T cell function, and how these may contribute to phenotypes associated with ITK deficiency

The data indicate that increased ITK expression could act as a disease activity marker and as a risk factor for involvement in SLE, but it still needs further study to confirm.

We conclude that ITK, formerly considered an immune cell-specific protein, is aberrantly expressed in melanoma and promotes tumor development and progression

The kinase Itk and the adaptor TSAd (zeige SH2D2A Proteine) change the specificity of the kinase Lck (zeige LCK Proteine) in T cells by promoting the phosphorylation of Tyr192.

Found that 38% and 14% of the Angioimmunoblastic T-cell lymphoma cases exhibited gains of ITK and SYK (zeige SYK Proteine) genes, respectively.

These data indicate that PRN694 is a highly selective and potent covalent inhibitor of ITK and RLK (zeige TXK Proteine), and its extended target residence time enables durable attenuation of effector cells in vitro and in vivo.

ITK Protein Überblick

Protein Überblick

This gene encodes an intracellular tyrosine kinase expressed in T-cells. The protein contains both SH2 and SH3 domains which are often found in intracellular kinases. It is thought to play a role in T-cell proliferation and differentiation.