The research and development of Clostridium butyrate (Clostridium difficile) in China has just started, but it has developed rapidly, and the product of Clostridium butyrate has appeared. Since 1993, from Japan, the importation of casein a meters of bm tablets and Mijalissen love Child a granules, successively in Shanghai, Guangzhou, Harbin and other more than 10 well-known hospitals clinical application, treatment of intestinal flora disorder caused by enteritis, diarrhea, indigestion and other diseases, has achieved remarkable results. At present, the research of Clostridium butyrate in our country is mainly in clinical application, but it is seldom used as feed additive.In addition, Clostridium butyrate can also be used as veterinary drugs, because of its resistance to streptomycin and other antibiotics, and the use of these antibiotics with their biological effects, but also to strengthen the treatment effect. The resistance of Clostridium butyrate to a variety of antibiotics is of particular significance to its effectiveness in the current situation where antibiotics are commonly added to the diet.Comparison with sodium butyrateSodium butyrate, also known as butyl acid sodium salt, the product is white to class white, like fluff, hygroscopic powder, with special cheese rancid like odor, soluble in water, aqueous solution ph is alkaline. Because butyric acid has the characteristics of free and volatile, it is made into relatively stable sodium-sodium butyrate in feed production. Sodium butyrate is one of the permissible feed additive varieties in China and was included in the catalogue of feed additive varieties in 2006 by the Ministry of Agriculture. In animal production, the main application is to add sodium butyrate products in animal feed, play the role of intestinal mucosal nutrition agent, electrolyte balance regulator, gastrointestinal micro-ecological regulator, compound acidification agent, fragrance agent, attractant and so on. At present, the domestic application of sodium butyrate in animal husbandry is mostly aimed at young animals. However, it is found that the effect of sodium butyrate product is not stable, and the reasons are as follows:⑴ Feed raw material has certain buffering ability to sodium butyrate: The buffering ability of feed raw material is the main factor that affects the free acid content in stomach. The greater the buffering capacity, the more free acid can be adsorbed in the stomach, which makes the free acid in the stomach decrease and the ph value increase in the stomach, which affects the activity of the pepsin and the digestion and decomposition of the protein. In general, the higher the content of protein, calcium, phosphorus and trace minerals, the higher the buffer capacity of feed.⑵ Sodium butyrate dosage is not good: sodium butyrate as organic acid, on the one hand, its dissociation degree is small, the acidity is weak, to achieve the same ability to add more acidification than inorganic acid is much larger, the added cost is high. On the other hand, sodium butyrate, as a acidizing agent, is directly added to the feed, and the added acid is easily neutralized by alkali. Loss of acidification, or absorption in the stomach too fast, but also reflex inhibition of gastric acid secretion, affect the normal development of gastric function; If the small intestine cannot reach, it can not effectively reduce the ph value in the small intestine, inhibit the growth of harmful microorganisms and promote the growth of beneficial bacteria. In addition, the type of diet, the age of animals, weight and feeding environment will affect the use of sodium butyrate.⑶ storage and transportation conditions are limited: sodium butyrate products in the normal storage and handling conditions, in the low temperature and sealed state of stability, but can not be contrary to the nature of the material, dust, overheating items, strong oxidant mixed preservation, storage process prone to dilute caking or caused feed damp.