The purpose of this study is to determine efficacy and safety of S-297995 for the treatment of opioid-induced constipation in subjects with non-malignant chronic pain receiving opioid therapy for ≥3 months

Average change from baseline in the number of spontaneous bowel movements (SBMs) per week when compared to the average number of SBMs per week during the last 2 weeks of treatment period [ Time Frame: From randomization to end of treatment period (4 weeks) ] [ Designated as safety issue: No ]

Secondary Outcome Measures:

Subject global satisfaction [ Time Frame: From randomization to end of treatment period (4 weeks) ] [ Designated as safety issue: No ]

History of chronic constipation prior to starting analgesic medication or any potential non-opioid cause of bowel dysfunction that may be a major contributor to the constipation

Severe constipation that has not been appropriately managed such that the subject is at immediate risk of developing serious complications of constipation

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Please refer to this study by its ClinicalTrials.gov identifier: NCT01443403