During the Hydra attack,thanks to Winter Soldier help Red Skull betrayed Madame Hydra, and took over Hydra leadership from her, wanting to get her revenge on him, Madame Hydra joined the Avengers Academy. With her help, and the Academy united again after Captain America and Iron Man resolved their issues, they were able to bring the Winter Soldier to their side and defeat Red Skull, after being defeated he was imprisoned at the Academy.[1]