There's also a lot to do during the first run between a trillion cookies (+1 heavenly chip) and a quintillion (+100). For example, the bingo center costs a quadrillion cookies.

This brings up an interesting thought though: I wonder how many people never look at the forum, the wiki, the subreddit, the source code, or any other way to find spoilers. You'd never find this out in the forum, but I bet some people consider any of that to be cheating and just play based on the game itself. It would be a different way to play, less efficient but maybe more exciting.