Vizquel had over 12,000 major league plate appearances, putting him at #17 on the all-time list when he retired. Most of the players near him on the list are in the Hall of Fame.

Vizquel is a drummer who did a rendition of the Goo Goo Dolls' "Broadway" on a CD of songs performed by baseball players.

When Omar signed with the Chicago White Sox for 2010, he requested #11, which had been retired by the club in honor of Aparicio. Aparicio agreed to have it brought back into use since Vizquel would be the player wearing it. He signed with the Toronto Blue Jays for 2012 for what would be his final season and made the team out of spring training as a utility infielder. At 44 (with a birthday less than a month from Opening Day making him officially 45 for the season), he was the oldest position player in the major leagues and one of the 50 oldest players ever. The records show that Vizquel's first career appearance in left field came on April 5th, in his first game for the Blue Jays, for just one batter. This is technically correct; however, Vizquel was positioned as a fifth infielder as part of a defensive shift. On May 6th, he became the oldest player to be used at shortstop, beating out Hall of FamerBobby Wallace, who had been 44 when he last played there for the St. Louis Cardinals in 1914. It was only his 7th appearance of the season, and he was barely hitting .133 at the time; he played 10 games at short that year. In his final game, Brett Lawrie let Little O wear his old #13 - Vizquel had worn #17 all season - and he got the start at shortstop, where he hadn't played since July 27th. He singled in his final at-bat against Alex Burnett; he was pulled from the game in the 9th inning to a standing ovation.

Vizquel retired after the 2012 season and a few months later was hired by the Los Angeles Angels of Anaheim to be a roving minor league infield instructor. In 2014, he was named first base coach of the Detroit Tigers under new manager Brad Ausmus. That year, he was also inducted into the Cleveland Indians' Hall of Fame.