This paper describes a significant biotechnological advancement by creating a minimalist serum-free defined system to co-culture rat mammalian nerve and muscle cells in order to form functional… (More)

BACKGROUND
Soluble oligomers of amyloid beta (Abeta) are considered to be one of the major contributing factors to the development of Alzheimer's disease. Most therapeutic development studies have… (More)

This paper presents an efficient method for updating echo canceller (EC) coefficients in ADSL transceivers during transmission that removes the dependency of updates on the far end signal. The new… (More)

This work documents the development of an in vitro cell culture model consisting of a novel serum-free medium and a non-biological growth substrate, N-1[3 (trimethoxysilyl) propyl] diethylenetriamine… (More)

Stack allocation of objects reduces the cost of object allocation and garbage collection and can thus lead to large reductions in runtime. Escape analysis can statically determine which objects are… (More)

Although the majority of human illnesses occur during adulthood, most of the available in vitro disease models are based upon cells obtained from embryonic/fetal tissues because of the difficulties… (More)

Cardiac side effects are one of the major causes of drug candidate failures in preclinical drug development or in clinical trials and are responsible for the retraction of several already marketed… (More)