2. Shared genes

All animals sit on the same branch of the evolutionary tree and share thousands of genes. Many of these ancient genes are unchanged at the DNA level despite a billion years of evolution.

3. Single gene diseases

Single gene diseases are caused by a spectrum of mutations and result in cellular defects. Missense mutations prevent proteins from folding correctly, which causes partial loss of gene function. Nonsense mutations prevent protein production, which a causes complete loss of gene function.

4. Gene editing

5. Automated drug screening

The resulting disease models manifest cellular defects that can be reversed by novel chemical entities in drug screens. The first version of the PerlArk™ Platform leverages multi-well plate technology and automation.