As a continuation to the last post: after Seroquel's former UK medical adviser John Blenkinsopp wouldn't play hide the results hardball or sign onto the Seroquel fudging the data promotional marketing tour "link here" ; AstraZeneca brought on board someone that would....that was that man about town playboy and ghost writing connoisseur Wayne MacFadden. __________________________________

Now Furious Seasons blogger Philip Dawdy revealed a dynamite legal filing describing how Dr. Wayne MacFadden, AZ’s former US medical director for Seroquel and director clinical research in CNS had affairs with a clinical researcher who authored publications favorable to Seroquel, and a medical marketer who promoted Seroquel through medical publications and other means.
The plaintiffs claim the affairs may have biased the science. AZ is seeking to exclude the evidence. AZ made this statement to FS:

“AstraZeneca had no knowledge of these relationships at the time,” says Laura Woodin, an AstraZeneca spokeswoman in an email. Macfadden’s relationships with the women ran from 2002 to 2006, according to court records. “Dr. MacFadden is no longer employed with the Company.” Woodin added, “AstraZeneca has audited and stands behind the integrity of its Seroquel trial data.”

You can download the filing for yourself here. But if you can’t be bothered to read it, here’s a digest:

MacFadden became involved in a sexual relationship with an (Institute of Psychiatry) researcher who, as well as being involved in other Seroquel-related projects, participated in the clinical research and abstract preparation relating to the effectiveness of Seroquel for use in the treatment of schizophrenia. Their affair lasted from 2002 to 2006.
Sometime during 2004, while collaborating with Parexel and while still involved in a sexual relationship with the IOP researcher, MacFadden became involved in a sexual relationship with the Parexel Program Manager responsible for AstraZeneca.
The nature of their communications suggest a level of control and dependence between Macfadden and these women.

The IOP researcher suggested that Macfadden would ‘punish’ her if she even looked at studies that were favorable to Seroquel’s competitors. He actively encouraged her to conduct research the results of which would be favorable to Seroquel and AstraZeneca, and promised sexual favors in exchange for intelligence on Astrazeneca’s competitiors.
In addition to his sexual involvement with the Parexel program manager, it appears he [Macfadden] also provided her with prescription painkillers.

Macfadden agreed that sexual relationships between clinical researchers and management members of pharmaceutical companies can create bias which can affect the integrity of the science. Macfadden also acknowledged that sexual relationships can affect a person’s judgment. Although Macfadden denies that his multiple sexual relationships with these women created a conflict of interest, he in fact teased the IOP researcher about the obvious conflict of interest as he reviewed drafts of her papers on Seroquel.”
Macfadden has admitted to additional sexual affairs with a clinical researcher assistant at AstraZeneca and a clinical researcher in California also involved in the Seroquel clinical trials.

_________________________________

picture via the world renowned PharmaGiles

So you might want to ask yourself?....what's so damned important, relevant, and embarrassing that AstraZeneca has their lawyers clamoring to stop these swore depositions from getting out in the public domain...I have an inkling that AstraZeneca is hoping that by working out this low ball settlement & cover up; the public will never see or hear the truth about Seroquel....think about the public safety & health issues/ramifications hiding this information may cause or will cause in the future when this drug goes generic, and is passed out like some candy after dinner mints...

On a side note...Wayne MacFadden has somehow kept his picture/photo under a mysterious veil of secrecy for many years now...if anyone has a photo of this Amorous Man about Town & former AstraZeneca Medical Director; please pass it along through email....

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