Yeah, I have a temporary workaround, because I have two monitors, so I just sortof try to get the Windows cursor over onto the other monitor. Every once in a while I have to hit tab and swipe to the right a couple times, then continue :)

and also to strafe clockwise around people instead of counterclockwise :X

Nexus Mods has a fix for this in their "Utilities" section, but I think it doesn't work since Skyrim's latest patch.

It is an annoying problem.

One thing I use is "Game Companion" to put Skyrim in Fake Fullscreen mode. I can alt-tab without the mouse pointer glitch, and I can switch from game to desktop and back again, instantly. Plus, the fake fullscreen mode doubles as a stutter remover, working around the 64 hz glitch. =)

Head over to NEW VEGAS nexus (works on just about any game) and search for "Game Companion", unzip to whatever permanent directory you want it in. (When you run it the first time it puts a registry entry in your win reg so it starts when you boot up) Then set up Skyrim to run in windowed mode and set the resolution to the same as your desktop. You may need to add the filename of the Skyrim executable into the Game Companion .ini file too. Instructions come with it, it's really easy to set up and works wonders.