"The Democrats are the party of Lisa Simpson," Cruz said of the character who is portrayed on the show as being a bit of a know-it-all. "And Republicans are happily the party of Homer, Bart, Maggie and Marge."

Al Jean, showrunner for the long-running animated Fox series, struck back on Twitter saying Cruz needed the character of baby Maggie's pacifier.

"Ted Cruz says Maggie Simpson would vote for him," Jean tweeted. "I think Ted's the one who could use a pacifier in his mouth."

Jean also joked that with the "way things are going even Mr. Burns (the show's billionaire character) is thinking of becoming a Democrat."

"The Simpsons" is known for getting political and even had an episode in 2000 that predicted Donald Trump would become President (with Lisa Simpson being elected after him and inheriting his budget crisis).