Call it a Holiday Hangover, maybe a little too much holiday good cheer, or just plain euphoria that the sun is out after almost two weeks of gloom. But it simply didn’t seem right to blog about the lethal side of ANYTHING this week.

Some time ago I happened uponan interesting article about the benefits of psychedelic drugs—WHAT?? And, being a child of the 60s, it peaked my interest.

Not that I dabbled in recreational drugs back in college when it was all the rage. I really didn’t! I’ve always had an innate fear that a little of a good thing may be fine, but too much could be injurious or even lethal.

That mindset is what interested me about this article. It focused on “a little of a good thing” and suggested that, since the late 1990s, there’s been a resurgence of medical research on the benefits of psychedelic drugs. This viewpoint particularly caught my attention since I’ve written blogs in the past about the detrimental, and even lethal, effects regarding the recreational (and sinister) use of certain chemicals.

More than 50 years ago, the US government funded labs to study psychedelic drugs like lysergic acid diethylamide (LSD) and other psychedelics as promising, powerful new drugs. Unfortunately, recreational use of these drugs evolved (think Woodstock, etc) and that caused the US government to ban further testing of many hallucinogenics/psychedelics as dangerous and to classify them as having no accepted medical use.

Officially, these drugs are categorized as Schedule I drugs, meaning they are illegal in the US for any use (medical or otherwise), and the government’s more recent war on drugs has severely limited research opportunities on psychedelics.

However, some research continues—much of it outside of the United States—and the benefits of several psychedelic drugs are beginning to be appreciated once again. One overwhelming truth seems to emerge from these studies. It’s the fact that the fears that psychedelic drugs cause an increased risk of mental illnesses are unfounded. In reality, these studies are taking a fresh, objective new look at the potential use of psychedelics to TREAT mental illnesses.

LSD is one of those drugs being studied with renewed interest. In research that goes back 40 years, LSD was shown to significantly reduce anxiety in patients facing end of life issues. A more recent Swiss controlled study involving terminally ill cancer patients revealed a 20% reduction in associated anxiety and depression regarding their impending demise when using LSD.

Other studies indicate that long-term use of LSD resulted in a considerable reduction in outpatient mental health treatments and lowered the use of powerful psychiatric medications. Like LSD, other psychedelics are being studied and interesting benefits are being revealed.

Psilocybin—more commonly known as the hallucinogenic component of “magic mushrooms”—has been studied for its calming effects on certain brain functions. Psilocybin is said to eliminate confusing/overwhelming thoughts and leads to increased cognition and memory.

Patients treated with psilocybin recall memories more vividly and accurately, and this effect has been confirmed on a neurobiological level with MRI scanning of the brain.

Psilocybin has also been shown to have significant benefits in treating alcoholism and smoking addiction. In fact, one study followed five patients who were given this drug to kick their smoking habit and all five completely quit smoking after one treatment. With follow-up visits of up to one year after treatment, four of the five were biologically confirmed to have continually abstained from cigarettes.

In the past I’ve blogged about a couple of interesting recreational drugs that can be deadly if used indiscriminately: MDMA (commonly called Molly) and DMT (dimethyltryptamine). Both seem to also have beneficial effects when used properly.

MDMA, the psychoactive chemical in the recreational drug ecstasy, has been shown to successfully treat post-traumatic stress disorder (PTSD) in military veterans and to decrease the anxiety associated with cancer treatments.

Interestingly, a slight chemical modification of MDMA has been studied at the University of Birmingham and it’s been shown to have aggressive anti-cancer potential. The study is preliminary and further studies are being conducted regarding this intriguing effect.

Other studies on MDMA support beneficial effects for treating the social anxiety in autistic adults, with a fascinating 77% increase in both ease in social settings and the ability to communicate more effectively with others.

DMT is the psychoactive compound found in a Peruvian Amazon rainforest vine that is used to make a brew called ayahuasca. Ayahuasca is utilized for spiritual and healing purposes in that area of the world, and in recent years DMT is appearing as a recreational street drug for its hallucinogenic effects.

From a medical treatment standpoint, DMT seems to “untangle” complex and unconscious psychological stresses and is of benefit in treating various depressions, cancer treatment anxiety, and increasing the hopefulness and quality of life for multiple sclerosis patients.

So the silver lining is that these potentially dangerous drugs that are often abused and lead to detrimental, or even lethal outcomes, can have a more benevolent quality to them when channeled properly.

As with most things, both good and bad can result from the decisions we make and the actions we take as humans. What path results from those decisions and actions often make for great story telling.

Thoughts? Comments? I’d love to hear them!

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About James J. Murray, Fiction Writer

With experience in both pharmaceutical manufacturing and clinical patient management, medications and their impact on one’s quality of life have been my expertise. My secret passion of murder and mayhem, however, is a whole other matter. I’ve always loved reading murder mysteries and thrillers, and longed to weave such tales of my own. Drawing on my clinical expertise as a pharmacist and my infatuation with the lethal effects of drugs, my tales of murder, mayhem and medicine will have you looking over your shoulder and suspicious of anything in your medicine cabinet.

3 Responses to A Psychedelic Silver Lining!

You never cease to amaze me with the gems that emerge from that fertile mind of yours! The mindless banning of those drugs/chemicals you mention seems to be the US government’s way of abdicating any commitment to research them and their potential benefits. Fortunately, as you point out, other countries are not as myopic. Researchers elsewhere are finding benefits that may very well offer stunning breakthroughs in dealing with ailments such as dementia and autism, among others, for which there appear to be no effective treatments. Thanks again for continuing to enlighten.

Regarding drugs used for recreation available on the street the biggest danger is the lack of control, the dangerous additives, and the questionable nature of what one is actually getting. I do think more research is needed regarding many of the “mind expanding” drugs as well as other drugs that could have potential recreational use that might not be as bad as some might think.

LSD might be especially valuable in many realms including treatment of mental illness and enhancing creative thought. I say research every aspect of the drug and allow it for controlled recreational use being sure that users are getting a pure unadulterated substance and perhaps controlling who is using it. I don’t think it should be available just for willy-nilly wild usage, but for certain consumers there might be a legitimate argument as to it’s availability to them.