Conclusions :
The results suggest that Compound 49b activates Epac1 to regulate VEGF signaling in REC, leading to reduced permeability and apoptosis. These data provide novel upstream pathways of VEGF that can potentially be used for novel therapies.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.