The dosage depends on the goal. People generally use 2 IU per day for anti aging purposes, between 4 to 6 IU for bodybuilding, weight loss and fitness, between 8 to 16 IU is used for short duration to treat severe burns or recover after injuries.

Doses below 3IU per day usually bring no side effects while people can notice the improvement of their skin, better sleep, more energy, eating junk food without gaining weight, etc.

After several weeks at 4IU and above some people will start to feel some side effects of somatropin. Slight water retention can be noticed in your fingers, toes and face (HGH makes the muscle cells hold more water and are thus temporarily inflated). Some people occasionally feel tingling sensation in their fingers and palms - this is known as carpal tunnel syndrome. It is described in detail in the "effects of HGH" section. In practice carpal tunnel syndrome is the only side effect which actually bothers the user. Most athletes simply ignore it and continue the cycle for as long as they can. If the carpal becomes unbearable, they lower the dose or discontinue use until the side effects are gone. It usually takes about 2-3 weeks for the carpal tunnel syndrome to completely disappear.

When using 4IU and above, it is good to split the dose in two daily injections. Half in the morning and the other half in late afternoon. You should avoid taking HGH before bedtime because the body releases its endogenous HGH (3rd dose) when you falls asleep. If you take the dose before bedtime it might interfere with your endogenous HGH release.

I wonder if these HGH figures are really just an indirect measure of physical activity.

On average, people become increasingly inactive as they get older, (of-course, there are exceptional individuals).

And we know that physical activity generally raises HGH levels.

The average level of HGH ranges between 800mcg at age 20 and 400mcg age 30.

It seems to me, that for most people, aged over 50,

200mcg would be sufficient to raise HGH levels to the levels of your 30s.

This is based off a simple reading of the chart presented in my earlier post (2 or 3 posts up).

The website above is suggesting 666mcg for 'anti-aging'. But that would put most people over

50 on 866mcg. That would be more than an average 20 year old gets !

Who has published these guidelines ? Could it be the manufacturers ?

i.e. The very people who are likely to benefit by the sale of this product ?

Common sense suggests to me that an average 30 year old isn't deficient

in HGH. The average HGH level for a 30 year old is 400mcg.

It seems to me that a 40 year old, with an average level of HGH of 300mcg

Only needs 100mcg to bring him/her upto the HGH level of a 30 year old.

So that would be (less than) 1/3 of 1IU.

A 50 year old only needs 200 mcg to bring his/her HGH up to 400mcg.

So that would be (less than) 2/3 of 1IU.

I wonder if the 2IU recommendation expresses a desire for profit,

rather than any concerns for the good health of customers.

But returning to this 'HGH levels are an indirect measure of physical activity' hypothesis

I would like to see studies of the HGH levels of marathon runners, iron man & triathalon participants.

I wonder if someone has already done these studies... nicely tabulated by age and sex.

IGF-1 is a peptide that mediates some of the effects of growth hormone and acts through the IGF-1 receptor to control body growth and tissue remodeling.[21] In the brain, IGF-1 functions as a neurotrophic factor that, like BDNF, plays a significant role in cognition, neurogenesis, and neuronal survival.[14][22][23] Physical activity is associated with increased levels of serum IGF-1, which is known to contribute to neuroplasticity along with locally produced IGF-1 in the brain due to its capacity to cross the blood–brain barrier in the capillary bed and blood–cerebrospinal fluid barrier;[4][14][21][22] consequently one review noted that IGF-1 is a key mediator of exercise-induced adult neurogenesis, while a second review characterized it as a factor which links "body fitness" with "brain fitness".[21][22] The amount of IGF-1 released during exercise is positively correlated with exercise intensity and duration.[24]

But I wouldn't jump to any conclusions, experience dictates monster bodybuilders aren't significantly smarter than average.

Growth hormone in the brain: characteristics of specific brain targets for the hormone and their functional significance.
During the past decade studies have shown that growth hormone (GH) may exert profound effects on the central nervous system (CNS). For instance, GH replacement therapy was found to improve the psychological capabilities in adult GH deficient (GHD) patients. Furthermore, beneficial effects of the hormone on certain functions, including memory, mental alertness, motivation, and working capacity, have been reported. Likewise, GH treatment of GHD children has been observed to produce significant improvement in many behavioral problems seen in these individuals. Studies also indicated that GH therapy affects the cerebrospinal fluid levels of various hormones and neurotransmitters. Further support that the CNS is a target for GH emerges from observations indicating that the hormone may cross the blood-brain barrier (BBB) and from studies confirming the presence of GH receptors in the brain. It was previously shown that specific binding sites for GH are present in discrete areas in the CNS of both humans and rats. Among these regions are the choroid plexus, hippocampus, hypothalamus, and spinal cord. The density of GH binding in the various brain regions was found to decline with increasing age. More recently, we were able to clone and determine the structure of several GH receptors in the rat and human brain. Although the brain receptor proteins for the hormone were shown to differ in molecular size compared to those present in peripheral tissues the corresponding transcripts did not seem to differ from their peripheral congeners. GH receptors in the hypothalamus are likely to be involved in the regulatory mechanism for hormone secretion and those located in the choroid plexus have been suggested to have a role in the receptor-mediated transport of GH across the BBB. The functions mediated by the GH receptors identified in the hippocampus are not yet known but recently it was speculated that they may be involved in the hormone's action on memory and cognitive functions.

The contents of this post and some that follow were likely the result of viral marketing. Please report viral marketing where you see it as LongeCity requires that all advertisements be paid and done in line with our sponsorship policies rather than being viral marketing or such things. The community's help in this matter is much appreciated and helps us expand our advocacy and research activities.

What about the insulin resistance caused by the massive, and I mean massive amounts of GH these guys are taking?

We are NOT talking life extension here for sure.

Now, knowing bodybuilders like I do, I'm sure they are spiking as much insulin as they can too so the argument turns "chicken or egg" pretty quickly.

I've seen plenty of former bodybuilders that STILL display signs of GH gut years after competition, but in quite a few of those cases they took so much growth hormone they became diabetic and still take insulin.

Bolstering your post, my father is a 20 plus year diabetic (no GH...lol...) and while not obese, he does have a nice little "insulin gut."

In my humble opinion, that's not a good idea. And these guys don't look better for it.

Pictures of bodybuilders from the 1970s and 1980s didn't look like this.

They looked better than these guys.

Supra-normal levels of HGH is, to my mind, not a good idea.

playground.

could this be related to the enormous amount of food those bodybuilders consume in order to get muscle growth? i mean, if simply taking HGH causes growth of certain tissues, adding ton of food to the mix is logically going to cause some combustion. for non-body builders just take it with very little food, simple. also, im speculating what would happen with HGH and growing huge guts and then pumping yourself with probiotics, you will become some kind of a health bomb.

could this be related to the enormous amount of food those bodybuilders consume in order to get muscle growth? i mean, if simply taking HGH causes growth of certain tissues, adding ton of food to the mix is logically going to cause some combustion. for non-body builders just take it with very little food, simple. also, im speculating what would happen with HGH and growing huge guts and then pumping yourself with probiotics, you will become some kind of a health bomb.

They do often 'load' tons of carbs even if 'healthy carbs' and this further augments that Insulin response we are talking about...but HGH itself certainly DOES NOT lead to the kind of 'distension' referred here.

so whats the most reliable best source for HGH in conclusion? i spent most time on this thread reading about the positive or negative impact it might have but now im just interested in finding the best reliable souce of it!

so whats the most reliable best source for HGH in conclusion? i spent most time on this thread reading about the positive or negative impact it might have but now im just interested in finding the best reliable souce of it!

I think that's your sarcasm in attempt to exploit a response out of me; ironically - this has already been mentioned earlier in the thread and in others with a relative lack of speculation.

time is money my friend. i went through this thread and got stuck on the humorous parts of it and as i realized, i had to do other stuff as time flies fast thus missing out on any vital information for my gathering. now that im back, ill go through again quick because again, no time.

just a question before that tho, as HGH is known to enhance organs, could it be a possible penis enhancer? and please dont joke around, i dont really need it for this, but its very interesting thing for people to know.

as HGH is known to enhance organs, could it be a possible penis enhancer? and please dont joke around, i dont really need it for this, but its very interesting thing for people to know.

There are some minor anecdotes but no real solid proof that it can be used for P.E - but HGH rejuvenates every cell, tissue and organ in your body and enhances pretty much every nerve impulse; so at the least - you would have increased E.Q (erection quality) , higher libido and dramatically increased endurance..which is all consistent with what bodybuilders and other enthusiasts report.

Treatment with recombinant human growth hormone in adult patients with growth hormone deficiency increases nitric oxide and cyclic guanosine monophosphate (cGMP). We examined the functional in vitro effects of recombinant human growth hormone on tissue tension and cyclic nucleotide levels of human corpus cavernosum and detected changes in growth hormone in the cavernous and peripheral blood during different phases of penile erection.

MATERIALS AND METHODS:

Relaxant responses of human corpus cavernosum were investigated using the organ bath technique. Tissue levels of cGMP were determined by a specific radioimmunoassay after dose dependent exposition of isolated human corpus cavernosum strips to recombinant human growth hormone. In 35 healthy potent volunteers blood samples were obtained simultaneously from the corpus cavernosum and cubital vein during different functional conditions of the penis, including flaccidity, tumescence, rigidity and detumescence. Penile erection was induced by audiovisual and tactile stimulation. Serum growth hormone was determined by an immunoradiometric assay.

RESULTS:

Recombinant human growth hormone elicited dose dependent relaxation of human corpus cavernosum strips in vitro. The relaxing potency of recombinant human growth hormone was paralleled by its ability to elevate intracellular levels of cGMP. In vivo the peripheral growth hormone serum profile of the respective penile conditions did not significantly differ from those of cavernous serum. The main increase in growth hormone to greater than 90% was determined during developing penile tumescence, followed by a transient decrease afterward.

CONCLUSIONS:

These results suggest that penile erection may probably be induced by growth hormone through its cGMP stimulating activity on human corpus cavernosum smooth muscle.