David Ortiz hit a game-tying grand slam in the eighth inning Sunday, and Jarrod Saltalamacchia singled home the winning run in the ninth as the Red Sox walked off with a 6-5 win over the Detroit Tigers.

The series, tied at one game apiece, heads to Detroit for the next three games.

In the ninth, Jonny Gomes reached on a single off Rick Porcello, and he moved to second on a throwing error by Jose Iglesias -- who entered as a defensive replacement. A wild pitch sent Gomes to third, and Saltalamacchia's base hit to left capped Boston's improbable comeback.

The Tigers led 5-1 with two outs in the eighth before Ortiz belted the first pitch closer Joaquin Benoit threw in the game. Will Middlebrooks, who doubled off Jose Veras; Jacoby Ellsbury, who drew a walk from Drew Smyly; and Dustin Pedroia, who singled off Al Alburquerque to load the bases, all scored ahead of Ortiz.

The Tigers wasted a gem from starter Max Scherzer, who had a no-hitter for 5 2/3 innings before a Shane Victorino single. Scherzer struck out 13 in seven innings, giving up one run on two hits, two walks and a hit batter.

Boston was held hitless through 8 1/3 innings in Game 1.

Red Sox starter Clay Buchholz went 5 2/3 innings, giving up five runs on eight hits and no walks with six strikeouts.

Through five innings, Game 2 resembled Game 1, which ended in a 1-0 Detroit victory.

Scherzer picked up where Tigers pitchers left off in the opener, and Red Sox batters remained befuddled. The Detroit right-hander recorded nine strikeouts in five hitless innings as the Tigers led 1-0.

In the first 14 innings of the ALCS, Tigers pitchers recorded 26 strikeouts and allowed one hit against the Red Sox, who possessed one of baseball's most prolific offenses in the regular season.

The Tigers jumped on top in the second inning on Alex Avila's RBI single. Victor Martinez doubled, when to third on Jhonny Peralta's single and scored on Avila's hit to center.

Detroit's Miguel Cabrera hit a solo homer in the sixth, and Martinez added an RBI double to increase the lead to 3-0.

Avila's two-run homer in the sixth gave Detroit a five-run lead before Boston recorded a hit.

The Red Sox finally broke through for a run in the bottom of the sixth. Following Victorino's two-out single, Pedroia hit an RBI double.

Boston closer Koji Uehara pitched one scoreless inning for the win.

NOTES: Boston manager John Farrell altered his lineup for Game 2. Mike Carp replaced Mike Napoli at first base, batting fifth. Gomes was in left field with Daniel Nava -- the only Red Sox batter who had a hit in Game 1 -- on the bench. Saltalamacchia was behind the plate with David Ross on the bench. ... After starting at shortstop in Game 1, Iglesias was not in the Tigers' lineup for Game 2. Manager Jim Leyland opted to go with Peralta at short and Don Kelly in left field. ... Ortiz has played in all 63 Red Sox postseason games since 2003, tying Jason Varitek's club record for postseason appearances. ... Tigers RHP Anibal Sanchez's 12 strikeouts in six hitless innings in Game 1 marked the most K's by a pitcher before he allowed a hit in a postseason game in major league history. The previous record belonged to the Los Angeles Dodgers' Sandy Koufax, who struck out 10 Yankees before Elston Howard connected for New York's first hit in Game 1 of the 1963 World Series, a two-out single in the fifth inning.