In this sequel, vampire death dealer Selene (Kate Beckinsale) must fend off brutal attacks from both the Lycan clan and the Vampire faction that betrayed her since they are trying to use the blood of her and her daughter to become Vampire-Corvinus hybrids.

At a private clinic, a comatose patient (Jackson Gallagher), the subject of a scientist's (Charles Dance) cruel experiments, uses his psychic powers to bring an innocent nurse (Sharni Vinson) under his control.