Target details

Target details

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Alternative Name

UCHL1

Background

UCHL1 is a member of a gene family whose products hydrolyze small C-terminal adducts of ubiquitin to generate the ubiquitin monomer. Expression of UCHL1 is highly specific to neurons and to cells of the diffuse neuroendocrine system and their tumors. It is present in all neurons (Doran et al., 1983 [PubMed 6343558]).Synonyms: Ubiquitin carboxyl-terminal hydrolase isozyme L1, UCH-L1, Ubiquitin thiolesterase L1, Neuron cytoplasmic protein 9.5, PGP 9.5, PGP9.5Pathways: Parkinson's disease