Not a complete list, just the first ten to come to mind. I tried to stick to movies where the majority of the story takes place of the vehicle, which ruled out options like United 93, Wild Boys of the Road, Jaws, and Fitzcarraldo (Two-Lane Blacktop might be a stretch in that regard). I left off a couple more that I need to revisit (Stagecoach, The Hunt for Red October, Speed, etc.). Ships/submarines could probably be a completely separate list, as with spaceships.

edit:Knife in the Water probably belongs on there somewhere, possibly along with Death Proof, Night Train to Munich, The Train, and Gravity.

1. United 932. Pirates of the Caribbean: The Curse of the Black Pearl3. Airplane!4. Crimson Tide5. Operation Petticoat 6. Captains Courageous7. The Road Warrior8. Knife in the Water 9. Snowpiercer10. Dead Calm

That last slot could just as easily be Speed.

Other Honorable Mentions: Sherlock Holmes and the Terror by Night: one of the best of the Basil Rathbone/Sherlock Holmes seriesMurder on the Orient Express: obviously I haven't seen the new one. The 1974 film was my entry into Agatha Christie, but I also like the interesting direction taken by the Poirot TV show, which is much more train-centric

Stretching the scope a bit more:The Blues BrothersThelma & Louise

Not to be overlooked:All Is Lost Moana TenThe River WildTitanicTop GunYellow Submarine

I see pixote listed Sunshine, which is interesting to consider. It means I could include Alien and others could list 2001, but something about Spaceships make it too big of an eco system to be considered. If you're going to go there, you might as well say Earth is a vehicle on a massive scale.