WASHINGTON (AP) — Donald Trump captured a crucial victory over Hillary Clinton Tuesday night in Ohio, a Midwestern battleground drawn to his searing strain of economic populism. Clinton carried Virginia and Colorado, but other key battleground states remained exceptionally tight as an ugly and unpredictable presidential election lurched to an uncertain finish.

For Trump, victory in Ohio was vital to his hopes of winning the White House. Clinton’s campaign had expected easy victories in Virginia and Colorado, but those states took on new urgency as Trump showed surprising strength elsewhere in the country.

The uncertainty sent Dow futures and Asian markets tumbling, reflecting investor concern over what a Trump presidency might mean for the economy and trade.

As Clinton’s team anxiously waited for results to roll in, the candidate tweeted to supporters, “Whatever happens tonight, thank you for everything.”

Clinton, a fixture in American politics for decades, was hoping to become the first woman to serve as commander in chief. She faced stiff competition from Trump, the billionaire businessman who tapped into a searing strain of economic populism.

Trump picked up a number of reliably Republican states, while Clinton won in Democratic territory. But the race was to be determined by fewer than a dozen competitive states where the candidates spent millions of dollars and much of the fall wooing voters.

Exit polls underscored the deep divisions that have defined the 2016 contest. Women nationwide supported Clinton by a double-digit margin, while men were significantly more likely to back Trump. More than half of white voters backed the Republican, while nearly 9 in 10 blacks and two-thirds of Hispanics voted for the Democrat.

Control of the Senate was also at stake, with Democrats needing to net four states if Clinton wins the White House. Republicans held their ground in North Carolina and in Indiana, where GOP Rep. Todd Young defeated former Sen. Evan Bayh.

The 45th president will inherit an anxious nation, deeply divided by economic and educational opportunities, race and culture. The economy has rebounded from the depths of recession, though many Americans have yet to benefit. New terror threats from home and abroad have raised security fears.

Clinton asked voters to keep the White House in her party’s hands for a third straight term. She cast herself as heir to President Barack Obama’s legacy and pledged to make good on his unfinished agenda, including passing immigration legislation, tightening restrictions on guns and tweaking his signature health care law.

“I know how much responsibility goes with this,” Clinton said after voting Tuesday at her local polling station in Chappaqua, New York, with her husband, former President Bill Clinton, at her side. “So many people are counting on the outcome of this election, what it means for our country, and I will do the very best I can if I’m fortunate enough to win today.”

Trump, the New York real estate developer who lives in a gold-plated Manhattan penthouse, forged a striking connection with white, working-class Americans who feel left behind in the changing economy and diversifying country. He cast immigration, both from Latin America and the Middle East, as the root of many problems plaguing the nation and called for building a wall along the U.S.-Mexico border.

“I see so many hopes and so many dreams out there that didn’t happen, that could have happened, with leadership, with proper leadership,” he said by telephone on Fox News before casting his own ballot in Manhattan. “And people are hurt so badly.”

Seven in 10 Americans who went to the polls Tuesday said immigrants now in the country illegally should be allowed to stay, while just a quarter said they should be deported. More than half oppose building a border wall, according to the exit polls, which were conducted for The Associated Press and television networks by Edison Research.

The Republican Party’s tortured relationship with its nominee was evident right up to the end. Former President George W. Bush and wife Laura Bush declined to back Trump, instead selecting “none of the above” when they voted for president, according to spokesman Freddy Ford.

Trump set both parties on edge when he refused to say in the third and final debate whether he would accept the election’s results, citing with no evidence the possibility of a rigged outcome. His statement threatened to undermine a fundamental pillar of American democracy and raised the prospect that his fervent supporters would not view Clinton as a legitimate president if she won.

Asked Tuesday in an interview with Fox News if he would accept the election results, Trump continued to demur, saying “We’re going to see how things play out.”

Most problems that did pop up at polling places Tuesday appeared to be routine — the kinds of snags that come every four years, including long lines, machines not working properly and issues with ballots or voter rolls.

Even before Tuesday, almost 45 million people had cast ballots for president. Many expressed relief the end was in sight after an election season in which personal attacks often drowned out the issues.

Clinton has denounced Trump for calling Mexican immigrants “rapists” and promoting a ban on Muslims entering the U.S., and for his long line of remarks about women that culminated in an audio in which he bragged about grabbing their genitals. Her campaign was hoping high turnout among Hispanics push her over the top in states like Florida and Nevada.

“I grew up in a Hispanic family, and the way that Donald Trump has referred to illegal immigrants — being from illegal immigrants, I took that to heart,” said Angel Salazar, a 22-year-old sanitation associate from Oklahoma City. “I don’t like anything that he said. I don’t like his views. So I voted for Hillary Clinton because she supports us.”

Trump called his opponent “Crooked Hillary” for her use of a private email server as secretary of state and her complicated ties to the family’s Clinton Foundation.

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