Abstract

The apparatus, designed for solid-phase peptide synthesis, consists of a round-bottom flask, rocked on a wrist-shaker, and fitted with a special dropping funnel and a fritted filter disc embedded within the flask. The dropping funnel is designed to wash down the polymer adhering to the neck of the flask. Solvents are removed through the fritted disc. Entire synthesis, and the removal of peptide from the polymer, are carried out without opening or removing the vessel from the shaker.