Databases

Coexpression

Proteins whose genes are observed to be correlated in expression, across a large number of experiments.

STRING allows inspection of the interaction evidence for any given network. Choose any of the viewers above (disabled if not applicable in your network).

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:query proteins and first shell of interactors

white nodes:second shell of interactors

Node Content

empty nodes:proteins of unknown 3D structure

filled nodes:some 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

exeB

General secretion pathway protein B (236 aa)

Predicted Functional Partners:

exeA

General secretion pathway ATPase (472 aa)

0.887

pulN

Type II secretory pathway, component PulN (248 aa)

0.769

syd

Syd; Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (183 aa)

a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1

node2

node1 accession

node2 accession

node1 annotation

node2 annotation

score

IL1072

IL1474

IL1072

IL1474

Glycosyltransferase

Hypothetical protein

0.565

IL1072

IL1519

IL1072

IL1519

Glycosyltransferase

Hypothetical protein

0.778

IL1072

IL1711

IL1072

IL1711

Glycosyltransferase

Hypothetical protein

0.778

IL1072

IL2268

IL1072

IL2268

Glycosyltransferase

Hypothetical protein

0.603

IL1072

exeB

IL1072

IL1964

Glycosyltransferase

General secretion pathway protein B

0.737

IL1072

pulN

IL1072

IL2016

Glycosyltransferase

Type II secretory pathway, component PulN

0.691

IL1474

IL1072

IL1474

IL1072

Hypothetical protein

Glycosyltransferase

0.565

IL1474

IL1519

IL1474

IL1519

Hypothetical protein

Hypothetical protein

0.576

IL1474

IL1711

IL1474

IL1711

Hypothetical protein

Hypothetical protein

0.476

IL1474

exeB

IL1474

IL1964

Hypothetical protein

General secretion pathway protein B

0.727

IL1474

pulN

IL1474

IL2016

Hypothetical protein

Type II secretory pathway, component PulN

0.560

IL1474

syd

IL1474

IL0854

Hypothetical protein

Syd; Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function

0.707

IL1519

IL1072

IL1519

IL1072

Hypothetical protein

Glycosyltransferase

0.778

IL1519

IL1474

IL1519

IL1474

Hypothetical protein

Hypothetical protein

0.576

IL1519

IL1711

IL1519

IL1711

Hypothetical protein

Hypothetical protein

0.778

IL1519

IL2268

IL1519

IL2268

Hypothetical protein

Hypothetical protein

0.595

IL1519

exeB

IL1519

IL1964

Hypothetical protein

General secretion pathway protein B

0.725

IL1519

pulN

IL1519

IL2016

Hypothetical protein

Type II secretory pathway, component PulN

0.650

IL1519

syd

IL1519

IL0854

Hypothetical protein

Syd; Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function

0.419

IL1711

IL1072

IL1711

IL1072

Hypothetical protein

Glycosyltransferase

0.778

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Network Stats

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Functional enrichments in your networkNote: some enrichments may be expected here (why?)

Enrichment analysis is still ongoing, please wait ...

Statistical background

For the above enrichment analysis, the following statistical background is assumed: