Brothers Lincoln Burrows (Dominic Purcell) and Michael Scofield (Wentworth Miller) are on the loose again, after breaking out of a dangerous Panamanian prison, but the shadowy agents who framed Burrows for murder are on their trail, in the fourth season of this popular TV series. And unlike their last breakout, from a U.S. prison, when they were hoping to quietly disappear, the brothers now want revenge for the death of Scofield`s girlfriend.