is $0 ($0 – December 31, 2011). SHARE CAPITAL (a) Commonshares Authorized: (i) On April 5, 2012 ... 05 per Unit. Each Unit is comprised of one commonshare and one non-transferable warrant, a whole warrant entitling the holder thereof to purchase an additional commonshare ...Shares Value Issued and outstanding: # Balance, December 31, 2010 Changes in the year Balance, December 31, 2011 Issued on private placement Balance, June 30, 2012 — — During the six month period ended June 30, 2012:

of CommonStock subject to stock options that are exercisable or will be exercisable ... Includes 498, 047 shares of CommonStock subject to stock options that are exercisable or will be exercisable as of or within 60 days after March 15, 2013. Includes 40, 403 shares of Common

with respect to all commonstock shown as beneficially owned by them. Consists of 5, 943, 097 sharescommonstock issuable upon conversion of Series A Preferred Stock, 276, 548 sharescommonstock issuable upon conversion of Series B Preferred Stock and 350 ... Number of Shares Beneficially Owned Prior to this Offering Percentage of Shares Beneficially Owned Prior to this After this Offering Offering Name and address of beneficial owner(1) 5% Stockholders Third Rock Ventures, L

The following table summarizes the potential shares of commonstock ... in the computation of diluted loss per share as their effect would have been anti-dilutive. June 30, December 31, # # Class 3 Preference Shares Class 4 Preference SharesStock

on the number of shares of commonstock, shares of each class of preferred stock ... Yen U.S. dollars As of or for the Fiscal Years ended March 31, Net Assets per Share of CommonStock Net Income per Share of CommonStock Diluted Net Income per Share of CommonStock ¥ ¥ ... to allot shares or fractions of a share without consideration to all the shareholders or the holders of fractional shares, pursuant to the provisions of Article 88 of the “Law