Abstract：In view of the relatively poor ability to detect shellfish toxins in China, shellfish poisoning has become a very serious food safety problem. In this article, we show how microfluidic immune chip technology and chemiluminescence analysis can be combined to detect shellfish toxins, giving a fast, efficient, low-power and sensitive detection method superior to conventional methods. The most widely studied paralytic shellfish toxin-Saxitoxin (STX) was selected as the research object. Experiments were carried out on a microfluidic chemiluminescence detection platform by using a kit for the detection of STX. Then the standard curve was plotted and the detection limit was calculated. In the early stages of the experiment, the antibodies were coated on carboxyl polystyrene microspheres and analyzed qualitatively. The optimization of flow rate and dilution ratio of the substrate solution was subsequently carried out. Finally, the shellfish in the market were studied. By plotting the standard curve, the detection limit of STX was found to be 0.005675ng/mL, proving that sensitivity in food safety testing can be greatly improved by the use of microfluidic chip technology.