Inspired by nature

Innovative pest control derived from nature for gentle usage

The creation of flupyradifurone was inspired by the natural compound stemofoline – an isolate from Stemona japonica, a medicinal plant that grows mainly in South-East Asia. Stemofoline is an alkaloid with exciting insecticidal properties. For decades, scientists around the world have tried using this knowledge to develop a commercial crop protection but have failed in their attempts.

Bayer's research scientists have now succeeded in identifying which part of this complex natural product is responsible for its insecticidal action: the butenolide pharmacophore system addressing the nicotinic acetylcholine receptor (nAChR) in targeted pests. By combining it with two other chemical fragments, the scientists discovered that the efficacy and selectivity of the active ingredient could be significantly improved.

Registration Status

SIVANTO® prime has obtained its first approvals in Guatemala and Honduras. After this first important step further registrations are expected in 2014 and 2015.

Stemona japonica

Spectrum of SIVANTO® prime

Reaching a large spectrum of sucking pest and a diverse range of crops

SIVANTO® prime is a systemic insecticide that is flexible in application and offers excellent control of key adult and immature sucking pests.