...the debate about the clinical evidence of the so-called patient-prosthesis mismatch (PPM) arose again. In this context it was discussed which valve specific parameter has the biggest evidence for the PPM and therefore the geometric orifice area (GOA) was pointed out as an important factor...
…Methods: Commercially available surgical aortic bioprosthetic heart valves from different manufacturers were tested in a FDA / DIN conform Pulse Duplicator System (ViVitro Labs Inc., Victoria, Canada). The system …
...it was clearly demonstrated, that this GOA is a dynamic process over the whole ejection period, which significantly differed from the maximum reached GOA...

Thoracic endovascular aortic repair (TEVAR) has been introduced as a less invasive approach to the treatment of thoracic aortic aneurysm (TAA). However, the effectiveness of TEVAR in the treatment of TAA is often limited due to the complex anatomy of aortic arch...
...This study proposes a novel stent graft design with slit perforations that can positively alter the hemodynamics at the aortic arch while maintaining blood flow to supra-aortic branches...
… flow preservation at side branches. The system was driven by a pulse generator (SuperPump AR series, ViVitro Labs Inc., Victoria, BC, Canada) at a flow rate of 5 L/min and a pulse rate of 1 Hz. The reservoir level and mechanical …

Management of congenital malformations of the pulmonary artery and valve can be challenging. The severity often demands early intervention, which is rarely definitive due to the natural growth and multiple surgeries may be required...
...In this study, a simple valve design supported by an absorbable proximal stabilization ring is evaluated both in-vitro and in-vivo...
… In-vitro model and testing. All in-vitro testing was carried out in a pulsatile flow model using water as the test fluid (Fig. 2). Pulsatile flow and pressure were generated with an electromechanical piston pump (VSI Superpump, Vivitro Labs, Victoria, Canada) …

Aortic stiffness is altered by cardiovascular diseases and exacerbated in innate or pathological conditions, which might be detected by noninvasive vascular elastography....
...results suggest that the proposed model could detect and evaluate aortic aneurysm stiffness and may be useful clinically for the early and timely detection of degraded mechanical properties to impact patient outcomes....
… Hz. Normal and aneurysm aortic deformations were compared by pulsing mimicing vessels at 60 bpm, using a hydraulic pulse duplicator within a left ventricular model (Superpump system, Vivitro Inc., Victoria, BC, Canada) …

Continuous improvement in the mechanics, preservation and anticalcification treatment made bioprostheses the standard mode of valve replacement in the aging population. A novel Support System with large openings at the Commissural posts has been developed and the performance and durability of bioprostheses constructed went under evaluation.
… Heart valve pulse duplicator. A heart valve pulse duplicator Vivitro SPS3891 (Vivitro Systems Inc., Victoria, BC Canada) was used to measure
hemodynamic parameters. All tests were performed with the standard FDA waveform …

Chordae rupture is one of the main lesions observed in traumatic heart events that might lead to severe tricuspid valve (TV) regurgitation...
...we investigated the changes on TV geometry, mechanics, and function of ex-vivo porcine hearts following chordae rupture...
… The schematic of this apparatus is shown in Fig 1. In short, a positive displacement pump (SuperPump AR Series, Vivitro Labs, Inc., Victoria, BC, Canada) was utilized to induce passive beating in porcine hearts …

Studies have suggested that the anterior leaflet of the native mitral valve aid in the formation of an asymmetric vortex ring similar to that seen in healthy left ventricles...
...we seek to investigate if this physiological left ventricular vortex can be replicated solely by the inclusion of an “anterior leaflet-like” feature within a mechanical valve design and its subsequent effects on downstream turbulence....
...Situated within the working chamber was the left ventricular silicon phantom actuated by a pulsatile pump (ViVitro Labs Inc., Victoria, BC), the resulting ventricular pumping motion circulated a mixture of glycerin and water (40 …

Tissue engineered heart valves (TEHV) are being investigated to address the limitations of currently available valve prostheses...
...A bioreactor system was designed based on the Windkessel approach. Novel features including a purpose-built valve chamber and pressure feedback control were incorporated to maintain asepsis while achieving a range of hydrodynamic conditions....
… The bioreactor was used to assess the hydrodynamic performance of a bioprosthesis and the results were compared to those obtained with a ViVitro
Pulse Duplicator system (ViVitro Labs, Victoria, BC, Canada)...
...The bioreactor system was able to produce a range of pressure and flow conditions from static to resting adult left ventricular outflow tract to pathological including hypertension...

Polar strain (radial and circumferential) estimations can suffer from artifacts because the center of a nonsymmetrical carotid atherosclerotic artery, defining the coordinate system in cross-sectional view, can be misregistered...
...Two-affine model-based estimators for vascular ultrasound elastography in cross-sectional view of the artery are evaluated in a common framework of high-frame-rate imaging...
...This paper presents two affine model-based estimators, the affine phase-based estimator (APBE) developed in the framework of transverse oscillation (TO) beamforming, and the Lagrangian speckle model estimator (LSME)...

This work aims to create a dynamic, ultrasound-compatible, realistic and flexible phantom of the left and right ventricles, with application in the diagnosis, planning, treatment and training in the cardiovascular field for studies using echocardiography.
… the real tissues. Then, a commercial available computed-controlled dynamic piston pump (Vivitro Labs, Victoria, British Columbia, Canada) was used to pump water...
into the model and consequently deform it. This pump system

...This study focuses on investigating the hemodynamics inside an aneurysm for different inflow conditions and varying geometrical shapes. ...
… precisely controlled. Re and α were varied between 50-250 and 2-5, respectively. A ViVitro Labs pump system was used to pump the fluid and Particle Image Velocimetry (PIV) was used to perform velocity measurements. The flow …

Mitral subvalvular apparatus plays an important role in mitral and ventricular dynamics by preserving annuloventricular continuity, known to be fundamental for ventricular function...
...We address these issues through the design of a novel semistented and chorded mitral valve that better mimics the native mitral annulus, leaflets and chordae function and can be made from off-the-shelf biomaterials with the potential to be implanted percutaneously...
… Pulse duplicator setup We performed hydrodynamic testing in the mitral position on a hydro-mechanical pulse duplicator system (Vivitro Superpump System SP3891, Vivitro, Victoria, BC, Canada), described elsewhere [4]. We used a 25mm Sorin Bicarbon bileaflet …

After implantation of a transcatheter bioprosthetic heart valve its original circular circumference may become distorted, which can lead to changes in leaflet coaptation and leaflets that are stretched or sagging....
… Valve hydrodynamic performance data were collected using a commercially available left heart Pulse Duplicator (Vivitro Systems) at 0, 41, 80, and 123 M cycles; at these intervals, the valves mounted in the metallic adapter …

...The air volume shifts the pressure and flow rate waveforms in time and impact the physical operating conditions of the valves with constant input settings in the ViVitest software...
… Results obtained from current pulse duplicators are subject to the setup and physical testing settings. The ViVitro Pulse Duplicator from ViVitroLabs
Inc … Three different valves were tested in a ViVitro pulse duplicator where...