"Shopping cart" software?

How do I go about getting a shopping cart/purchasing system set up on a website? My uncle wants to expand his business to the internet, and he wants people to be able to buy stuff with paypal/credit cards.

Zencart/oscommerce is ugly no matter how you slice it; You can skin it till you're blue in the face but it'll always look like zencart/oscommerce and it'll always be ugly.

You can make it less ugly, but it'll never look particularly good. That being said, it's easy to navigate for the user because it is so cookie-cutter.

And don't get me wrong..... I actually recommend zencart to most people. And I think it is a great thing to start with. A custom webapp can be expensive, and should be considered down the line.... But to start-up, zen cart is great. And if you don't get a miva plan through dreamhost, you still get the one-click zencart install that's free. verfy easy.