"It's been an ongoing investigation into drug trafficking guns and gang activity in the Avondale neighborhood," Assistant Cincinnati Police Chief James Whalen said.

The plan was for an undercover officer to make a buy and for uniformed police to swoop in and make an arrest.

"The suspect vehicle backed, up rammed into a plainclothes Cincinnati police car," Whalen said. "The suspects emerged from the car -- at least one armed suspect, we have a weapon. We're following up on two suspects with guns."

Investigators said an officer fired shots and hit two of the subjects.

One died a short time later at an area hospital. The other was treated for non-life-threatening injuries at University Hospital.

The third subject ran off and forced police to block off streets and escort people back to their homes while search crews looked for the missing subject.

"We never want to use this kind of force to keep the community safe but police are trained to action," Mayor Mark Mallory said.

Many Avondale residents have been asking for police help to help clean up the community.

"Those of us who live here are not sitting on the sidelines, we're actively involved," Avondale Communicty Council member Ozie Davis said.

Davis said he's reminded of previous successful collaboration between police and the community and also of the work yet to be done.

"What's unfortunate on Thanksgiving eve we have the first homicide of the year in this neighborhood, it happens to be a police-involved shooting (and) that's unfortunate," Davis said.

By late Wednesday, police said the third person was still at large. They were last seen running toward the 1000 block of Burton Avenue.

The subject was described as a black man in his 20s wearing a black skull cap and black jacket.

Anyone with information on the whereabouts of the third man is asked to call police.

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