Working out radiation protection measures for new nuclear physics facilities,
evaluation of their radiation environment, and development of radiation safety systems for them.

As the results:

Acquisition of new data on the regularities and mechanisms of the initiation of molecular
disorders in the DNA structure; DNA damage repair; and radiation-induced apoptosis
in human cells under radiations with different linear energy transfer (LET).

Decoding of the mechanisms underlying cell hypersensitivity and hyperresistance to low
doses of ionizing radiation.

Acquisition of comparative data on the regularities of the induction of gene and
structural mutations in mammalian and yeast cells by radiations with different LET.

Drawing up recommendations on the threshold doses of heavy charged particles able
to damage the eye lens and retina. Development of the preventive measures against
cataract in persons occupationally exposed to irradiation with heavy charged particles.

Research on the character of the heavy charged particle-induced damage of central
nervous system (CNS) cells and regularities of their death. Identification of the
heavy charged particle-induced functional disorders in the CNS.

Mathematical modeling of the mutagenic effect of ionizing radiations with different
LET on bacterial and mammalian cells.

Calculation of the radiation shielding of new nuclear physics facilities; evaluation
of the radiation environment and development of radiation safety systems.

Estimation of the galactic radiation dose received by cosmonauts in different flight
scenarios for working out the criteria and grounds of the radiation safety standards
for interplanetary flights.

Acquisition of new data on the performances of nanotechnology-based thermoluminescent
detectors.

Expected main results in 2014:

Continuation of research on the regularities of DNA damage induction and repair in
human and mammalian cells in the presence of modifiers of DNA replication and repair synthesis.

Continuation of research on the mechanisms of radiation-induced apoptosis and
different ways of DNA damage repair under ionizing radiations of different qualities.

Continuation of research on the regularities of the formation and repair of DNA double-strand breaks
and clustered damage using the method of DNA foci.

Continuation of research on the induction of gene and structural mutations in yeast cells by ionizing radiations of different LET.

Completion of the experiments on the induction of gene and structural mutations in yeast cells by ultraviolet and gamma radiation.

Performing a comparative analysis of the induction of the HPRT gene structural mutations and morphological changes in mutant
subclones of mammalian cells by radiations of different LET.

Continuation of research on the mechanisms of the action of low doses of radiations of different LET with the use of modifiers
of the intracellular cytoprotective systems.

Continuation of the acquisition of data on the regularities in the functional disorders in the rodent retina
induced by radiations of different qualities and mutagens.

Carrying out a study of the structural characteristics of the photoreceptor membrane containing the visual pigment rhodopsin – the receptor associated with the G-proteins.

Development of a model approach to the description of the functional disorders in the rodent retina induced by ionizing radiations and mutagenes.

Performing a research on the specifics of the biological effect of protons of different energies on the mouse organism.

Carrying out an evaluation of the exposure of the central nervous system to the galactic and solar cosmic rays during a two-year
interplanetary flight performed in different periods of the solar cycle.

Continuation of the development of mathematical models of the functional activity of neurons under exposure to radiations of different LET.

Development of a conceptual model of the diminution of an operator's functioning reliability associated with disorders in higher nervous activity.

Continuation of the development of mathematical models of DNA double-strand break induction and repair in human cells.

Conduction of radiobiological experiments at the Nuclotron (LHEP), U-400M (FLNR), and the medical beam of the Phasotron (DLNP).

Carrying out the molecular dynamics modeling of the structural and functional properties of the DNA photolyase protein, G-proteins,
and the protein rhodopsin surrounded by amino acid residues.