Avoid diving a Poppy due to her passive making her deceptively tanky.
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334

Only the target selected by Poppy's ultimate can damage/CC her during the duration. You need to choose quickly if you're going to stay and fight her, or if you're going to run away from her.
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326

Don't be next to a wall when targetted by a Poppy as her Heroic Charge will stun you.Report

27

Try to pick a support with a shield or heal against Poppy. By shielding the target you delay her assassination attempt while her ultimate is active. If her target survives the duration of her ultimate, Poppy becomes useless as she can be focused easily.Report

Any damage dealt to Poppy that exceeds 10% of her current health is reduced by 50%. This does not reduce damage from structures.

Devastating Blow

Q

Active: Poppy enhances her next auto attack so that it deals bonus flat amount and an additional 8% of the targets max health as magic damage. The damage based on 8% of the targets max health cannot exceed a threshold.Cost: 55 mana

Passive: Upon being hit or attacking an enemy, Poppys armor and damage are increased for 5 seconds. This effect can stack 10 times. Active: Poppy gains max stacks of Paragon of Demacia and her movement speed is increased for 5 seconds.Cooldown: 12 seconds

Active: Poppy charges at an enemy and carries them further. The initial impact deals a small amount of magic damage, and if they collide with terrain, her target will take a high amount of magic damage and be stunned for 1.5 seconds.Range: 525Carry distance: approx 300

Active: Poppy focuses intensely on a single enemy champion, dealing increased damage to them, and becoming immune to any damage, disruptions, or abilities from any enemies other than her target (including tower damage). Damage increase applies to summoner spells and items used by Poppy. The effect will end prematurely if her target dies.Cost: 100 manaRange: 900