Prostate Cancer Cell Line (22Rv1-undup1)

Human prostate cancer cell line, 22Rv1-undup1 is one of the clones isolated from 22Rv1 that is genetically corrected using TAL effector nuclease to delete the tandem duplication of 2b-exon3-CE1-3 of androgen receptor genome in 22Rv1 cell that drives the expression of androgen receptor variant 7 (ARv7).

Highlights:

Expresses ARv7

ARvs level is significantly reduced by this AR genomic correction

Prostate cancer is the development of cancer in the prostate, a gland in the male reproductive system. The androgen receptor (AR) helps prostate cancer cells to survive and is a target for many anti cancer research studies by looking at inhibition.