Charlie Sheen -- I've Never Done Heroin

4/30/2011 11:29 AM PDT BY TMZ STAFF

Chuck Lorre must have the wrong monkey (*wink wink, nudge nudge) because Charlie Sheen tells us in no uncertain terms ... he's never done heroin!

Lorre took a not-so-veiled shot at Sheen on his vanity card at the end of "The Big Bang Theory" earlier this week. Lorre made reference to a monkey on the show behaving "increasingly erratic" and being "a heroin addict" -- but we all know who he was really referring to.

But Sheen tells TMZ point blank, "I have never done or tried heroin in my life."