Processor registers are normally at the top of the memory hierarchy, and provide the fastest way to access data. The term normally refers only to the group of registers that are directly encoded as part of an instruction, as defined by the instruction set. However, modern high-performance CPUs often have duplicates of these "architectural registers" in order to improve performance via register renaming, allowing parallel and speculative execution. Modern x86 design acquired these techniques around 1995 with the releases of Pentium Pro, Cyrix 6x86, Nx586, and AMD K5.

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Registers are normally measured by the number of bits they can hold, for example, an "8-bit register" or a "32-bit register". A processor often contains several kinds of registers, that can be classified according to their content or instructions that operate on them:

User-accessible registers – instructions that can be read or written by machine instructions. The most common division of user-accessible registers is into data registers and address registers.

Data registers can hold numeric values such as integer and, in some architectures, floating-point values, as well as characters, small bit arrays and other data. In some older and low end CPUs, a special data register, known as the accumulator, is used implicitly for many operations.

Some processors contain registers that may only be used to hold an address or only to hold numeric values (in some cases used as an index register whose value is added as an offset from some address); others allow registers to hold either kind of quantity. A wide variety of possible addressing modes, used to specify the effective address of an operand, exist.

Special purpose registers (SPRs) hold program state; they usually include the program counter, also called the instruction pointer, and the status register; the program counter and status register might be combined in a program status word (PSW) register. The aforementioned stack pointer is sometimes also included in this group. Embedded microprocessors can also have registers corresponding to specialized hardware elements.

In some architectures, model-specific registers (also called machine-specific registers) store data and settings related to the processor itself. Because their meanings are attached to the design of a specific processor, they cannot be expected to remain standard between processor generations.

In some architectures, such as SPARC and MIPS, the first or last register in the integer register file is a pseudo-register in a way that it is hardwired to always return zero when read (mostly to simplify indexing modes), and it cannot be overwritten. In Alpha this is also done for the floating-point register file. As a result of this, register files are commonly quoted as having one register more than how many of them are actually usable; for example, 32 registers are quoted when only 31 of them fit within the above definition of a register.

The table shows the number of registers of several mainstream architectures. Note that in x86-compatible processors the stack pointer (ESP) is counted as an integer register, even though there are a limited number of instructions that may be used to operate on its contents. Similar caveats apply to most architectures.

The A register is an accumulator to which all arithmetic is done; the H and L registers can be used in combination as an address register; all registers can be used as operands in load/store/move/increment/decrement instructions and as the other operand in arithmetic instructions. There is no FP unit available.

Plus a stack pointer. The A register is an accumulator to which all arithmetic is done; the register pairs B+C, D+E, and H+L, can be used as address registers in some instructions; all registers can be used as operands in load/store/move/increment/decrement instructions and as the other operand in arithmetic instructions. Some instructions only use H+L; another instruction swaps H+L and D+E. There is no FP unit available.

80386 required 80387 for floating-point. with 80-bit stack registers; later processors had built-in floating point (hence always had 8 FP registers), with 80-bit stack registers, and had additional 128-bit XMM registers with SSE in the Pentium III and later

The Emotion Engine's main core contains four 32-bit general-purpose registers for integer computation and one register for general floating-point computation. The processor is also connected via 32 128-bit built-in vector registers to a vector coprocessor based on MIPS architecture.

This applies to S/360's successors, System/370 through System/390; FP was optional in System/360, and always present in S/370 and later. In processors with the Vector Facility, there are 16 vector registers containing a machine-dependent number of 32-bit elements.[6]

65C816 is the 16-bit successor of the 6502. X,Y, D (Direct Page register) are condition register and SP register are specific index only. main accumulator extended to 16-bit (B) while keep 8-bit (A) for compatibility and main register can now address up to 24-bit (16-bit wide data instruction/24-bit memory address).

Direct successor of 6502, 65002 only content A (Accumulator) register for main purpose data store and extend data wide to 32-bit and 64-bit instruction wide, support 48-bit virtual address in software mode, X,Y are still condition register and remain 8-bit and SP register are specific index but increase to 16-bit wide.

Each instruction controls whether registers are interpreted as integers or single precision floating point. Architecture is scalable to 4096 cores with 16 and 64 core implementations currently available.

The number of registers available on a processor and the operations that can be performed using those registers has a significant impact on the efficiency of code generated by optimizing compilers. The Strahler number of an expression tree gives the minimum number of registers required to evaluate that expression tree.