Weekend in Medellin

Hi All,I'm looking for some helpful tips on places to stay and things to do over a weekend visit to Medellin. The idea is to get a real feel for the city.We will be two girls, so safety is important in terms of location, and El Poblado was recommended, is this a good idea?Also any other useful information will be appreciatedThanks for any help and if anyone is willing to play tour guide that is also welcome :)