Bill Cosby's sexual assault trial has ended without a verdict after jurors failed to break a deadlock.

Jurors had deliberated for more than 52 hours over six days before telling a judge they could not reach a unanimous decision on whether The Cosby Show star drugged and molested Temple University employee Andrea Constand at his suburban Philadelphia home in 2004.

The judge at Montgomery County Courthouse in Norristown, Pennsylvania, then declared a mistrial.

Cosby, 79, had been charged with three counts of aggravated indecent assault.

His lawyer said the entertainer and Constand were lovers sharing a consensual sexual encounter.

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Cosby (second left) stands as his publicist, Andrew Wyatt, addresses the media after the trial

Approximately 60 accusations of sexual assault have been made against Cosby over a number of years, but only Constand's resulted in criminal charges because the other alleged incidents were too old to prosecute.

Montgomery County District Attorney Kevin Steele vowed on Saturday to bring Cosby to justice.

Following the declaration of a mistrial, Steele said: "We have made the determination of moving forward, and it lies in the fact she deserves a verdict in this this case ... and we will push forward to try and get justice done."

"We hope that moving forward in this case sends a strong message that victims of these types of crimes can come forward and can be heard on what has happened to them."