DESCRIPTION (provided by applicant): The investigators propose to accelerate fine-mapping and identification of causal mutations for four traits (portosystemic vascular anomalies, owner-directed aggression, orthopedic traits and lymphoma) by whole genome sequencing, one affected and one unaffected dog for each trait (eight dogs total). Discovery of new sequence variations at loci associated with the traits will enable follow-up mutation detection and deliver trait-associated variants that will be included in a future improved canine genotyping array.