• at approximately 3 weeks of age, analysis of basal electroencephalograph recordings indicated no differences between wild-type and heterozygous null mice: pentylenetetrazole (PTZ) induced seizures in both genotypes, resulting in several presageful sharp waves followed by an explosion of seizures

• the PTZ-induced seizure was a generalized seizure, which simultaneously occurred in all regions of the cerebrum in both wild-type and heterozygous null mice

• however, wild-type mice required a greater number of PTZ injections to induce seizures than heterozygous null mice, suggesting that young heterozygotess are hypersensitive to PTZ-induced seizures

• at approximately 3 weeks of age, analysis of basal electroencephalograph recordings indicated no differences between wild-type and heterozygous null mice: pentylenetetrazole (PTZ) induced seizures in both genotypes, resulting in several presageful sharp waves followed by an explosion of seizures

• the PTZ-induced seizure was a generalized seizure, which simultaneously occurred in all regions of the cerebrum in both wild-type and heterozygous null mice

• however, wild-type mice required a greater number of PTZ injections to induce seizures than heterozygous null mice, suggesting that young heterozygotess are hypersensitive to PTZ-induced seizures