My Research Interests:

My research focuses on using network and pathway-based analysis to generate biologically relevant hypothesis based on high-throughput studies: sequencing data, gene expression, shRNA screen, and proteomics data. I’m looking for regions of highly-interconnected proteins that can serve as prognostic and predictive signatures to use in cancer patient management.

I am interested in the prediction of biologically relevant protein interactions and reconstruction of the comprehensive protein-protein interaction network based on biological pathways from expert curation and from integration of the high-throughput datasets and databases.

Some of my projects are dedicated to chemotherapy resistance which remains a major challenge in the treatment of cancer. Unfortunately, resistance exists against EVERY effective anticancer drug. I am interested in developing biomakers that will predict how sensitive this particular tumor to the treatment what will allow us to choose the best combination of the drugs.