Ranitidine (Includes Zantac 25 mg EFFERdose) ↔ Liver Disease

Moderate Potential Hazard, Low plausibility

Applies to: Liver Disease

Ranitidine is partially metabolized by the liver. Although dosage reductions are generally not necessary, therapy with ranitidine should be administered cautiously in patients with liver disease. Elevated ALT (SGPT) has been observed in patients receiving ranitidine intravenously at dosages greater than those normally recommended for 5 days or more.

Ranitidine (Includes Zantac 25 mg EFFERdose) ↔ Pku

Moderate Potential Hazard, High plausibility

Applies to: Phenylketonuria

Zantac (brand of ranitidine) 150 EFFERdose tablets and granules both contain 16.84 mg of phenylalanine per each 150 mg of ranitidine. The phenylalanine content should be considered when these products are used in patients who must restrict their intake of phenylalanine (i.e. phenylketonurics).

References

Ranitidine (Includes Zantac 25 mg EFFERdose) ↔ Renal Dysfunction

Moderate Potential Hazard, High plausibility

Applies to: Renal Dysfunction

Ranitidine is primarily eliminated by the kidney. Although the drug is generally well-tolerated, the daily dosage should initially be reduced in patients with moderate to severe renal impairment (CrCl < 50 mL/min). If necessary, the daily dosage may be increased with caution.

Do not stop taking any medications without consulting your healthcare provider.

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