The names Gidzenko, Krikalyov, and Shepherd were names seen on a mission insignia in the 602 Club. They were the first inhabitants of the space station on Expedition 1. Their mission patch, seen in the 602 Club, showed the space station on a blue background and the names of the Russian astronauts were written in their native Cyrillic alphabet.

E. Michael Fincke, who appeared, along with fellow NASA astronaut Terry Virts in ENT: "These Are the Voyages...", has spent a year, total, aboard the ISS, from April to October 2004 (speaking with Scott Bakula while in space) and again from October 2008 to April 2009 - Virts himself piloted the shuttle Endeavour on a mission to the station in February 2010. He later returned to the station in November 2014 as Flight Engineer of Expedition 42/43.

According to the reference work Ships of the Line (p. 8), in the 2150s, the ISS has remained in Low Earth Orbit and hasn't been destroyed by a controlled re-entry. (In the real world, the ISS is planned for controlled re-entry in 2024/2028, a similar fate to MIR)

From the Encyclopedia (4th ed., vol. 1, p. 372), "The International Space Station (ISS) was featured in the main title sequence of Star Trek: Enterprise, beginning with the first episode, "Broken Bow". The decision to add the ISS to the Enterprise titles was a last-minute decision on the part of the producers. Because there was so little time to obtain accurate reference information for the construction of a digital model for visual effects, NASA engineer (and Star Trek fan) Brian J. Young, who at the time was a technician working for the United Space Alliance at NASA's Kennedy Space Center in Florida, went back to work on a Friday night and faxed us the plans for the station!"