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Whenever I take 1 Vitamin B-50 complex (Twinlab brand) per day, I develop the following side effects after a couple of days of usage: anxiety; clumsiness; feeling cold; and feeling like thereís a big lump in my chest. So far I have tested taking folic acid (400 mcg) , biotin (300 mcg) and vitamin b5 (500mg) separately (at equal or larger doses than in the B-50) and these do not produce any side effects (individually or combined).

Does anyone have any suggestions as to what might cause these side effects?

The next step will be adding Vitamin B6 (5mg) and Vitamin B12 (200mg).

I should add some more information for clarification. I have previously taken 1 B-50 capsule a day for several years, it wasnít until this summer that I came to the realisation that his supplementation had led to the effects I mentioned in my first post, mainly some anxiety and feeling cold most of the time. Also since Iíve stopped with the B-50 my girlfriend has commented on how warm I feel all the time. Now I didnít experience only side effects from the B-50, it actually had quite a positive impact on my memory and clarity of thought (in my subjective opinion).

could be an allergy to one of the fillers. Have you tried any other brance of b-50...some of them contain inositol and choline as well in different forms. Also i know a few ppl who are allergic to any more than a few mcg of b-12 in a b vit.

"Absorb what is useful, reject what is useless." - Bruce Lee

"Note the emphasis on slight and initially, which is different than huge and forever." - MD

[quote name='FunkMasterFlex' date='Nov 13 2005, 03:20 PM']could be an allergy to one of the fillers. Have you tried any other brance of b-50...some of them contain inositol and choline as well in different forms. Also i know a few ppl who are allergic to any more than a few mcg of b-12 in a b vit.

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I'd suspect something along these lines. The only one of the B vitamins that really even qualifies as remotely toxic is B6 and even then it takes grams/day of it over weeks. Niacin can be hepatotoxic but would not give symptoms like you describe.

[quote name='FunkMasterFlex' date='Nov 13 2005, 12:20 PM']could be an allergy to one of the fillers. Have you tried any other brance of b-50...some of them contain inositol and choline as well in different forms. Also i know a few ppl who are allergic to any more than a few mcg of b-12 in a b vit.

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I have tried other brands, with and without inositol och choline. The effects are the same.

Clearly what Iím experiencing could be oversensitivity to one or more of the synthetic forms of B-vitamins. The page ATB linked to provide other possibilities.

As for B-12, sublingual B-12 at 500mcg per day increases my appetite to an extreme degree after a couple of days accompanied by a general feeling of weirdness.

the b-50 complex.. does it have that orange/yellow color coating? and of the individual B componemts that you have taken individually.. do they also share that same color coating.. ornageish yellow so typical of B vitamins

[quote name='triceptor' date='Nov 13 2005, 12:55 PM']the b-50 complex.. does it have that orange/yellow color coating? and of the individual B componemts that you have taken individually.. do they also share* that same color coating.. ornageish yellow so typical of B vitamins

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The B-50 I currently have is a twinlab brand which contains capsules, the contents of the capsules is yellowish (the riboflavin I assume) other brands have been tablets and they have sometimes been colored by the means of iron and titanium oxide.

the fact that you notice that lump feeling at the base of the neck area and your feelings of hypothermia make me suspicious that something in the B-complex you are taking is having some action on your thyroid. B-6 is important to thyroid function. I'm wondering if a filler or coating is having the undesired effect? Hypothyroid can cause brain-fog and effect cognition as a result of the shutting down of peripheral blood flow to the brain. Another symptom is also anxiety. How about these symptoms..

ringing in the ears

tingling in the extremeties like pinky fingers or small toes

cold feet, especialy at night

also, do your symptoms seem to be worst in the early morning and begin to normalize later in the day

[quote name='triceptor' date='Nov 13 2005, 01:02 PM']the fact that you notice that lump feeling at the base of the neck area and your feelings of hypothermia make me suspicious that something in the B-complex you are taking is having some action on your thyroid. B-6 is important to thyroid function. I'm wondering if a filler or coating is having the undesired effect? Hypothyroid can cause brain-fog and effect cognition as a result of the shutting down of peripheral blood flow to the brain. Another symptom is also anxiety. How about these symptoms..

ringing in the ears

tingling in the extremeties like pinky fingers or small toes

cold feet, especialy at night

also, do your symptoms seem to be worst in the early morning and begin to normalize later in the day

If you want to test if it is thyroid functioning you should try some kind of thyroid test. You can take 12.5mcg T3 a day for a few weeks and see if that clears up your symptoms. 12.5mcg a day isn't really enough to get major side effects in case it isn't, but it should help stabalize thyroid levels if you are low.

You should also take your temperature (preferably via the underarm) right when you wake up. If it is lower than 97.8F that also points to the idea that it could be thyroid functioning.

this article clearly implicates long term high doses of B6 to eventually impair thyroid function through a shift int he T4/T3 ratios that eventually cauee hypothyroidism.

This is very intersting and deserves additional research. This may be your issue. Your symptoms sound like they are thyroid related - hypo. And if there is a very low level of free T3, the symptoms are similar to hypothyroidism.

Vitamin B6 supplementation on a long-term basis has the potential to eventually lower thyroid functions even more, although a brief boost will

still take place every time Vitamin B6 is injected or taken orally.* In addition, Vitamin B6 will only affect T4 (thyroxine) levels, but no conversion to T3 (triiodothyronine) takes place - causing a T3 / T4 thyroid ratio conflict,

[quote name='Juche' date='Nov 13 2005, 03:23 PM']If you want to test if it is thyroid functioning you should try some kind of thyroid test. You can take 12.5mcg T3 a day for a few weeks and see if that clears up your symptoms. 12.5mcg a day isn't really enough to get major side effects in case it isn't, but it should help stabalize thyroid levels if you are low.

You should also take your temperature (preferably via the underarm) right when you wake up. If it is lower than 97.8F that also points to the idea that it could be thyroid functioning.