Moore, PA

Beverley Moore, North Wales, PA US

Patent application number

Description

Published

20130040994

Methods of Treatment Using Allosteric Processing Inhibitors for Matrix Metalloproteinases - The present invention includes a crystal comprising a complex of the pro form of a matrix metalloprotease (proMMP) and a small-molecule allosteric processing inhibitor that inhibits that activation of the proMMP, methods for identifying small-molecule allosteric processing inhibitors that inhibit the activation of a proMMP, and methods of treatment using small-molecule allosteric processing inhibitors that inhibit the activation of a proMMP. The present invention relates to the crystal structure of a complex of proMMP9 bound to a small-molecule allosteric processing inhibitor that inhibits activation of proMMP9. The invention further relates to the use of the methods and the crystal and related structural information for designing, selecting and/or optimizing small-molecule allosteric processing inhibitors that inhibit activation of proMMP9 and proMMP9 homologues. The present invention also relates to the use of small-molecule allosteric processing inhibitors for the treatment of diseases mediated by inappropriate matrix metalloproteinase (MMP) activity.

Caleb Moore, Indianhead, PA US

Patent application number

Description

Published

20140208633

OVER-CENTER TRIGGER MECHANISM FOR ANIMAL CAGE TRAPS AND CONVERSION KIT - A trigger mechanism for an animal cage having a door that can be closed by linking to hanging bait comprises a frame for mounting to that cage. The frame includes a first support pivotally mounted at its base end, a second support fixedly mounted substantially perpendicular to the frame; and a door actuation bar pivotally mounted to the frame at one end. That actuation bar connects to a latch on the cage door and pulls on that latch to close the door when an animal inside the cage engages bait hanging from a strike arm pivotally mounted at one end to the second frame support. A link arm pivotally mounted at one end to the first frame support connects at its opposite end to an intermediate point along the strike arm with varying levels of tension. A kit for converting animal cages from floor pedal actuation to this hanging bait improvement is also disclosed.

07-31-2014

Charles C. Moore, Hibbs, PA US

Patent application number

Description

Published

20090194346

Automated Remote Carriage for Tightening Generator Wedges - A remote-controlled dynamoelectric machine maintenance vehicle that can fit and travel within the air gap between a stator and rotor of a dynamoelectric machine. The maintenance vehicle has an effectuator that can remotely attach to an adjustable wedge within a coil slot of the stator and tighten the wedge in position and then move on to repeat the process until all the wedges on the stator are secured.

08-06-2009

20090301168

Apparatus For Impact Testing For Electric Generator Stator Wedge Tightness - A remote-controlled dynamoelectric machine inspection vehicle that can fit and travel within a narrow air gap between a stator and rotor of a dynamoelectric machine. The inspection vehicle has an effectuator that can remotely activate a hammer driven by a high pressure pneumatic three-stage miniature piston that propels the hammer against a stator slot wedge creating an impact force that causes the wedge to vibrate. The vibrations are sensed to determine the tightness of the wedge.

12-10-2009

20130283583

TURBINE EXTENSION NUT SUPPORT TOOL - A nut support tool for assembly and disassembly of a nut on a vertically extending bolt assembly located on a casing. The bolt assembly including a lower nut engaged on a lower end of a threaded shaft. The nut support tool includes a vertical span assembly having an upper support member located at an upper end thereof for engagement on an upper end of the bolt assembly, whereby the nut support tool is supported from the bolt assembly upper end with the vertical span structure extending parallel to the bolt assembly. An arm assembly extends from a lower end of the vertical span assembly and includes a lower guide pin for engagement with an access opening formed in a lower surface of the lower nut. The arm assembly is configured to support the lower nut, and to swivel relative to the casing.

Charles S. Moore, Langhorne, PA US

Patent application number

Description

Published

20080200129

Method and apparatus for determining modulation levels that are supported on a channel - A logical channel is configured to match a modulation profile of an active channel. A network element is assigned to the logical channel and a ping request is sent to the network element. A response from the network element is measured, such as measuring the MER. The modulation profile is increased in the logical channel and another ping request is sent to the network element. The response is measured again, and the process is repeated until a non-linearity is detected in the response. The acceptable modulation profiles are indicated before the non-linearity is detected in the response.

08-21-2008

20100157824

Methods and System for Determining a Dominant Impairment of an Impaired Communication Channel - Methods are described for identifying a dominant impairment on a communication channel impaired by an interference issue. The methods include systematic examination of total power loading, systematic examination of signal power reduction, statistical examination of communication channel noise power, and systematic examination of interleaver effectiveness. Each relates to automatically diagnosing and characterizing distortion-based interference issues by monitoring the performance of a communication channel during a testing procedure. These methods enable a technician or engineer to remotely diagnose distortion-based interference issues relatively quickly without having to use external test equipment and without having to deploy technicians to various locations within the cable plant. A system by which these methods can be implemented is also disclosed.

06-24-2010

20100158093

Methods and System for Determining a Dominant Impairment of an Impaired Communication Channel - Methods are described for identifying a dominant impairment on a communication channel impaired by an interference issue. The methods include systematic examination of total power loading, systematic examination of signal power reduction, statistical examination of communication channel noise power, and systematic examination of interleaver effectiveness. Each relates to automatically diagnosing and characterizing distortion-based interference issues by monitoring the performance of a communication channel during a testing procedure. These methods enable a technician or engineer to remotely diagnose distortion-based interference issues relatively quickly without having to use external test equipment and without having to deploy technicians to various locations within the cable plant. A system by which these methods can be implemented is also disclosed.

METHOD AND APPARATUS FOR UPDATING EQUALIZATION COEFFICIENTS OF ADAPTIVE PRE-EQUALIZERS - A method and apparatus for updating equalization coefficients of an adaptive pre-equalizer of a network element are provided. The method includes monitoring a communications channel to measure distortion of a communications signal received from the network element and detecting whether a transient impairment is present in the communication signal. When a transient impairment is not detected to be present, a pre-equalization coefficient update is transmitted to the network element. However, when a transient impairment is detected to be present, at least selected ones of the pre-equalization coefficients are scaled before the update is transmitted to the network element or the update is withheld from being transmitted to the network element. An apparatus is also disclosed.

02-28-2013

20140029654

METHOD AND APPARATUS FOR CHARACTERIZING IMPULSE NOISEAND OPTIMIZING DATA LINK EFFICIENCY - Method and apparatus for characterizing an impulse noise impairment impacting communications over data links of a network are provided. A test signal comprising a bit stream of a predetermined bit sequence and packet size is configured and transmitted over the data links. The test signal is received, and the bit stream of the test signal as transmitted is compared to a bit stream of the test signal as received to identify differences in bit sequence. Thereafter, characteristics of the impulse noise impairment impacting communications between the data links are estimated based on the detected differences in bit sequence.

01-30-2014

20140029655

METHOD OF CHARACTERIZING IMPAIRMENTS DETECTED BY EQUALIZATION ON A CHANNEL OF A NETWORK - An automated method of characterizing distortion detected by equalization on a channel of a network is provided. Equalization stress of an observed channel equalization response of an end device of the network is estimated, and equalization stress is calculated for a theoretical channel equalization response of the end device mathematically based on the observed channel equalization response and a theoretical removal of a suspected impairment from the network. The above referenced calculating step is separately repeated for each of a plurality of suspected impairments stored in a database of suspected impairments. A highest ranking suspected dominant impairment is determined from the database of suspected impairments such that removal of the highest ranking suspected dominant impairment from the network would provide a greatest reduction of equalization stress of a channel equalization response of the end device.

Donald E. Moore, Morrisville, PA US

Patent application number

Description

Published

20100243979

Animal Proof Hooded Barrier, Related Enclosure Systems and Method of Maintaining an Animal Proof Domain - The invention encompasses a substantially animal-proof barrier (“APB”) that includes (a) two supports that are laterally spaced apart to define a substantially vertical plane there between; (b) fencing material that is attached to each of the supports and spans the defined substantially vertical plane to form a simple barrier that has a top edge, a bottom edge, a front surface and a back surface, wherein the simple barrier divides a domain into a first area and a second area; and (c) a hood having an inner surface, the hood originating from the top edge of the simple barrier. An angle formed by the inner surface of the hood and the front surface of the simple barrier measures about 10 degrees to about 80 degrees, such that a channel having a substantially V-shaped cross section is formed.

09-30-2010

20140345537

ANIMAL PROOF HOODED BARRIER, RELATED ENCLOSURE SYSTEMS AND METHOD OF MAINTAINING AN ANIMAL PROOF DOMAIN - The invention encompasses a substantially animal-proof barrier that includes (a) two supports that are laterally spaced apart to define a substantially vertical plane there between; (b) fencing material that is attached to each of the supports and spans the defined substantially vertical plane to form a simple barrier that has a top edge, a bottom edge, a front surface and a back surface, wherein the simple barrier divides a domain into a first area and a second area; and (c) a hood having an inner surface, the hood originating from the top edge of the simple barrier. An angle formed by the inner surface of the hood and the front surface of the simple barrier measures about 10 degrees to about 80 degrees, such that a channel having a substantially V-shaped cross section is formed.

11-27-2014

D. Suzanne Moore, Kennett Square, PA US

Patent application number

Description

Published

20100287246

SYSTEM FOR PROCESSING ELECTRONIC MAIL MESSAGES WITH SPECIALLY ENCODED ADDRESSES - A method for processing an electronic mail message is disclosed comprising the steps of: accepting a request for e-mail server address information for an electronic message having an address, the address having an electronic mail receiving system domain with a recipient name encoded therein; providing an e-mail server address for the recipient name in response to the request; accepting the electronic message at the e-mail server address.

Gordon Moore, Wayne, PA US

Materials and methods to increase peptide chain expression - DNA sequences that increase peptide chain expression when operably linked to a gene encoding the peptide chain and methods of generating a peptide chain expression host cell using the foregoing are disclosed. Peptide chain expression host cells are also disclosed.

09-04-2008

James A. Moore, Beaver, PA US

Patent application number

Description

Published

20120207664

SYSTEMS AND METHODS FOR RECOVERING NITRIC ACID FROM PICKLING SOLUTIONS - An embodiment of a method for recovering nitric acid from acid pickling solution includes introducing a treating material comprising at least one chemical into a pickling solution comprising free nitric acid. The treating material reacts with at least a portion of the free nitric acid in the pickling solution and produces NO

SYSTEM FOR TREATING NOx-CONTAINING GAS STREAMS - In one embodiment, a system for treating a gas stream comprising NOx generated from an acid pickling solution includes a first chamber and a second chamber. The first chamber includes a first inlet communicating with a source of a gas comprising NOx, a second inlet communicating with a source of ozone, and an interior volume adapted to contact the gas comprising NOx introduced through the first inlet with the ozone introduced through the second inlet. The second chamber directly fluidly communicates with the first chamber and receives gaseous effluent comprising nitric acid from the first chamber. The second chamber includes a third inlet communicating with a source of water vapor, an interior volume adapted to contact the gaseous effluent from the first chamber with the water vapor, thereby solubilizing nitric acid in the gaseous effluent with the water vapor to provide a solubilized nitric acid, and an outlet for collecting solubilized nitric acid from the interior volume of the second chamber.

James R. Moore, Milton, PA US

Patent application number

Description

Published

20130318736

Decorating Tip Cleaning Apparatus - A decorating tip cleaning apparatus includes a first frame member having opposed front and rear edges and a second frame member having opposed front and rear edges. The rear edges of the frame members are pivotally coupled together such that the first and the second frame members are movable between a closed configuration at which the front edges, respectively, are generally adjacent one another and an open configuration at which the front edges, respectively, are separated from one another. The first and second frame members include a mesh material extending between respective front and rear edges. The mesh material of the first frame member defines a plurality of apertures spaced apart from one another, each aperture being configured to receive a decorating tip partially therethrough. Each aperture is configured to receive only a portion of a respective decorating tip.

12-05-2013

John R. Moore, Lansdale, PA US

Patent application number

Description

Published

20090130317

HOT AIR DRIER ASSEMBLY FOR A WATERBORNE PAINT SPRAY BOOTH - The disclosure relates to a hot air drier assembly for a solvent and waterborne paint spray booth for drying a substrate coated with liquid waterborne basecoat located inside the spray booth, comprising: a free-standing portable heat exchange device with a hot air outlet directed towards the substrate and a heat exchange fluid heating device located remotely from the paint spray booth and in fluid communication with the heat exchange device via heat exchange fluid conduits which are in fluid communication with heat exchange fluid conducting tubes for heating spray booth air directed from the spray booth air intake to the heat is exchange chamber and out the hot air outlet. The disclosure additionally relates to a paint spray booth incorporating the hot air drier assembly and methods for drying a substrate using the hot air drier assembly.

05-21-2009

20100032872

SOLUTION SPUN FIBER PROCESS - The invention relates to a process for forming fibers from a spinning solution utilizing a high speed rotary sprayer. The fibers can be collected into a uniform web for selective barrier end uses. Fibers with an average fiber diameter of less that 1,000 nm can be produced.

02-11-2010

20130112689

CAPPING DEVICE FOR CONTAINERS - The present disclosure is directed to a capping device for containers. The capping device can comprise a cap member and a cylindrical base body and can comprise two engagement pairs having two different engagement mechanisms for engaging the cap member and the cylindrical base body. The capping device can be used for containers for liquid material, powder material, particulate material, or a combination thereof.

05-09-2013

20140199484

PROCESS AND SYSTEM FOR PRODUCING WATERBORNE COATING LAYER IN HIGH TEMPERATURE AND LOW HUMIDITY CLIMATE - The present disclosure is directed to a process for applying a waterborne coating composition in a spray booth and a system thereof. The disclosure is particularly directed a process for introducing water into incoming air for the spray booth to produce a conditioned spray booth having appropriate humidity levels. The process of this disclosure is particularly useful for applying waterborne coating composition having effect pigments in a low humidity and high temperature climate.

07-17-2014

Patent applications by John R. Moore, Lansdale, PA US

Jonathan Moore, Philadephia, PA US

Patent application number

Description

Published

20140281854

HYPERMEDIA REPRESENTATION OF AN OBJECT MODEL - A method and system may allow for converting an object model. For example, a computing device may receive an object model to be converted to a document that represents the object model. The computing device may be configured to traverse the object model and build a document (e.g., an XHTML document, XML document, etc.) that represents the object model. The document may comprise a series of tags that represent objects in the object model. The computing device may then provide the document as a part of a hypermedia API.

09-18-2014

Jonathan Moore, Philadelphia, PA US

Patent application number

Description

Published

20140053166

Adaptable Application Programming Interfaces and Specification Of Same - Aspects of the disclosure relate to defining and/or specifying an application programming interface (API) between a client and a computing device (such as a server) in a manner that the client, the computing device, or both, can evolve independently while preserving inter-operability.

02-20-2014

20140095712

In-Memory Personalized Content Delivery Architecture - A content network is presented where at least one of non-personalized data commonly applicable to a user base and personalized data is maintained. In an aspect, each element of the personalized data may be applicable to at least one, but less than all, of users within the user base. The non-personalized data may be stored across a plurality of servers included in a group, and the personalized data is stored across at least one, but less than all, of the plurality of computing devices included in the group. An update to data stored may be received and a determination made as to whether the update to data is to the non-personalized data or the personalized data. Then, one of the non-personalized data or the personalized data set stored in the server may be updated.

04-03-2014

20140101722

Secure Content Access Authorization - A secure content delivery or access method may include coordination among three devices such as servers—a content management server, a delivery server, and an authorization server. A request for content may originate from an authorization server application, and may involve the application obtaining two digitally signed tokens for the request. The first token may be from the authorization server, and may include a content management server identifier for the requested content. The second token may include two identifiers for the content: the first identifier being the content management server identifier, and the second being a delivery server identifier. The first and second tokens may be signed by the authorization server and content management server, respectively, and may be delivered to the delivery server for validation. Successful validation may result in the delivery server providing a content decryption key for the requested content to a device requesting the content.

04-10-2014

20140249657

Systems And Methods For Controlling Devices - Systems and methods for managing device controls are disclosed. One method can comprise determining an orientation of a controller and comparing the orientation of the controller and an activation orientation. If the orientation of the controller substantially matches the activation orientation, a control relationship between the controller and the user device may be automatically activated, and if the orientation of the controller does not substantially match the activation orientation, control options to a user of the controller.

09-04-2014

20150039668

Adaptable Application Programming Interfaces And Specification Of Same - Aspects of the disclosure relate to defining and/or specifying an application programming interface (API) between a client and a computing device (such as a server) in a manner that the client, the computing device, or both, can evolve independently while preserving inter-operability.

02-05-2015

20150134967

Trusted Communication Session And Content Delivery - Methods and systems for configuring a network are disclosed. An example method can comprise receiving a first token and an encryption key from a first device. A second token can be received from a second device. A determination can be made as to whether the first token matches the second token. Configuration information can be provided to the second device if the second token matches the first token. The configuration information can comprise information for connecting to a proxy configured on the first device. A request for content can be received from the proxy on behalf of the second device. The request for content can comprise the encryption key.

05-14-2015

Jonathan T. Moore, Philadelphia, PA US

Patent application number

Description

Published

20090313295

System and Process for Connecting Media Content - A system for correlating a user's interests to media content, said system comprising: (a) at least one data store comprising media content data relating to people, works, and tags; (b) a relationship generator configured to generate direct relationships among said people, works and tags; (c) a connection module to generate connections between a primary person, work or tag and a first set of said people, works, and tags, wherein each person, work and tag of said first set has a direct relationship with said primary person, work or tag; and (d) a display module for causing the display of at least a portion of said first set of said people, works and tags.

12-17-2009

20100299437

Web Service System and Method - A system for providing a web service on a network of addressable nodes, said web service comprising a plurality of discrete, individually-addressable microservices, said system comprising: (a) at least one load balancer configured for routing a request from a node for a microservice to one of a plurality of virtual addresses, each virtual address corresponding to a unique microservice, and (b) one or more physical nodes associated with each virtual address, each physical node comprising one or more microservices, each microservice comprising a microservice-specific module for executing a particular function, said microservice-specific module linked to an interface for communicating over said network, each microservice being one of a plurality of individually-addressable microservices constituting a web service.

11-25-2010

20110126296

Method For Scalable Access Control Decisions - Content access may be provided and processed by assigning responsibility for obtaining entitlement data to the client's browser. Thus, in one example, the client may be configured to synchronize and coordinate data lookups associated with a content request, rather than relying on the server to do so. The network architecture may use a mediator design pattern, in which the client's browser acts as the mediator (i.e., middleman) between a content server and an entitlement data server. Accordingly, synchronous calls between server-side services might not be required. Instead, data necessary for the content server to process a client request for access to protected content may be received in the incoming request from the client's browser.

05-26-2011

20130138677

System and Process for Connecting Media Content - A system for correlating a user's interests to media content, said system comprising: (a) at least one data store comprising media content data relating to people, works, and tags; (b) a relationship generator configured to generate direct relationships among said people, works and tags; (c) a connection module to generate connections between a primary person, work or tag and a first set of said people, works, and tags, wherein each person, work and tag of said first set has a direct relationship with said primary person, work or tag; and (d) a display module for causing the display of at least a portion of said first set of said people, works and tags.

05-30-2013

20140373179

Method for Scalable Access Control Decisions - Content access may be provided and processed by assigning responsibility for obtaining entitlement data to the client's browser. Thus, in one example, the client may be configured to synchronize and coordinate data lookups associated with a content request, rather than relying on the server to do so. The network architecture may use a mediator design pattern, in which the client's browser acts as the mediator (i.e., middleman) between a content server and an entitlement data server. Accordingly, synchronous calls between server-side services might not be required. Instead, data necessary for the content server to process a client request for access to protected content may be received in the incoming request from the client's browser.

12-18-2014

Patent applications by Jonathan T. Moore, Philadelphia, PA US

Jonni S. Moore, Philadelphia, PA US

Patent application number

Description

Published

20140357505

System And Method Of Cytomic Vascular Health Profiling - The present invention relates to a method of determining vascular health in a subject. The method includes the steps of obtaining a biological sample from the subject, obtaining microparticle data based on the level of at least one set of microparticles in the biological sample, obtaining progenitor cell data based on the level of at least one set of progenitor cells in the biological sample, generating a cytometric fingerprint of the biological sample based on the microparticle and progenitor cell data, and determining the vascular health of the subject based on the generated cytometric fingerprint.

Keith P. Moore, Bensalem, PA US

Patent application number

Description

Published

20130018048

OXAZOLE DERIVATIVES USEFUL AS MODULATORS OF FAAH - The present invention is directed to certain Oxazole derivatives which are useful as modulators of Fatty Acid Amide Hydrolase (FAAH) and as FAAH imaging agents. The invention is also concerned with pharmaceutical formulations comprising these compounds as active ingredients and the use of the compounds and their formulations in the treatment of certain disorders, including osteoarthritis, rheumatoid arthritis, diabetic neuropathy, postherpetic neuralgia, skeletomuscular pain, and fibromyalgia, as well as acute pain, migraine, sleep disorder, Alzheimer Disease, and Parkinson's Disease.

01-17-2013

20130059850

AZA-INDOLE DERIVATIVES USEFUL AS MODULATORS OF FAAH - The present invention is directed to certain Aza-Indole derivatives which are useful as modulators of Fatty Acid Amide Hydrolase (FAAH) and as FAAH imaging agents. The invention is also concerned with pharmaceutical formulations comprising these compounds as active ingredients and the use of the compounds and their formulations in the treatment of certain disorders, including osteoarthritis, rheumatoid arthritis, diabetic neuropathy, postherpetic neuralgia, skeletomuscular pain, and fibromyalgia, as well as acute pain, migraine, sleep disorder, Alzheimer Disease, and Parkinson's Disease.

METHOD OF MAKING A BICYCLIC GUANIDINE-CURED ACRYLIC COATING - Disclosed are electrodepositable coating compositions that include a cationic amine salt group-containing (meth)acrylic polymer in which the (meth)acrylic polymer is prepared by polymerizing a mixture of ethylenically unsaturated monomers comprising at least 10% by weight of a (meth)acrylic monomer containing hydroxy ester groups, the % by weight being based on total weight of ethylenically unsaturated monomers, and an acid salt of a guanidine or a guanidine reaction product. Associated methods of preparing an amine salt group containing composition and for coating a substrate are also disclosed. Substrates coated with the electrodepositable coating composition are also disclosed.

04-30-2015

Patent applications by Kelly Moore, Dunbar, PA US

Kelly L. Moore, Dunbar, PA US

Patent application number

Description

Published

20090236231

ELECTRODEPOSITION OF DIELECTRIC COATINGS ON SEMICONDUCTIVE SUBSTRATES - A method includes: immersing a semiconductive substrate in an electrodeposition composition, wherein at least 20 percent by weight of resin solids in the composition is a highly cross-linked microgel component, and applying a voltage between the substrate and the composition to form a dielectric coating on the substrate. A composition for use in electrodeposition includes a resin blend, a coalescing solvent, a catalyst, water, and a highly cross-linked migrogel, wherein at least 20 percent by weight of resin solids in the composition is the highly cross-linked microgel. Another composition for use in electrodeposition includes a surfactant blend, a low ion polyol, phenoxypropanol, a catalyst, water, a flexibilizer, and a highly cross-linked migrogel, wherein at least 20 percent by weight of resin solids in the composition is the highly cross-linked microgel.

ELECTRODEPOSITION OF DIELECTRIC COATINGS ON SEMICONDUCTIVE SUBSTRATES - A composition for use in electrodeposition includes a resin blend, a coalescing solvent, a catalyst, water, and a highly cross-linked migrogel, wherein at least 20 percent by weight of resin solids in the composition is the highly cross-linked microgel. Another composition for use in electrodeposition includes a surfactant blend, a low ion polyol, phenoxypropanol, a catalyst, water, a flexibilizer, and a highly cross-linked migrogel, wherein at least 20 percent by weight of resin solids in the composition is the highly cross-linked microgel.

01-12-2012

Patent applications by Kelly L. Moore, Dunbar, PA US

Mack Thomas Moore, Ephrata, PA US

Patent application number

Description

Published

20120138882

In-line strainer with tension control mechanisms for use on high tensile wire - An in-line strainer for placement within a span of wire fence to apply tension thereto is provided. The in-line strainer includes a reel having a hollow central hub for receiving a torque limiting mechanism. The torque limiting mechanism includes a central axle and a spring mechanism. As the axle is manually rotated, the reel is also rotated through its engagement with the torque limiting mechanism until a target tension on the wire is reached. Once the target tension has been reached, the torque limiting mechanism disengages, allowing the axle to “slip” relative to the reel, preventing further rotation of the reel and, consequently, further tensioning of the wire. In addition, the in-line strainer includes a failure mechanism which ensures that, when the load threshold on the fence is exceeded, the in-line strainer will automatically release tension on the wire wound thereon in a predictable and safe manner.

06-07-2012

Matthew Moore, Ephrata, PA US

Patent application number

Description

Published

20140200554

SUCTION CATHETER DEVICE AND METHOD - A device and method for removing material from inside a tube is provided, comprising a catheter having a tubular body and defining an inner lumen, the distal end portion of the tubular body defining a distal opening and apertures on a sidewall. An expandable member is attached to the distal end portion of the catheter tubular body distal to the one or more apertures. The expandable member is capable of having a first unexpanded condition such that the distal opening is open to allow fluid communication with the inner lumen of the catheter through said distal opening, and a second expanded condition such that the distal opening is occluded to prevent fluid communication with the inner lumen of the catheter through said distal opening, the second expanded condition of the expandable member having a maximum transverse diameter larger than a diameter of the tubular body proximal to the expandable member.

Michael Moore, Clarks Summit, PA US

Patent application number

Description

Published

20080228123

BANDAGE WITH A HYDROPHILIC FOAM CONTAINING SILVER AND A HEMASTATIC AGENT - A compression stretch bandage formed from a hydrophillic foam having at least one layer of a stretchable, textile material attached to one side of the foam and a hemastasis agent attached to another side of the foam for activating the intrinsic arm of the hemostatic cascade of the healing process. The bandage may also include a silver material contained within the foam for reducing risk of infection. The bandage may be a flexible, stretchable, hydrophilic bandage that reduces the risk of infection at a wound by providing a moist environment that will aid in optimum release of silver ions into the wound.

Michael F. Moore, Dunmore, PA US

Patent application number

Description

Published

20110091571

METHOD OF CONTROLLING THE PROPAGATION OF MRSA, STAPH AND OTHER INFECTIONS THAT COLONIZE IN THE NOSE - A method or protocol for reducing the spread of bacterial infections such as MRSA among a population includes identifying a group of individuals at risk of carrying or becoming carriers of a bacterial infection that colonizes in the nose, determining whether any individuals can be excluded from treatment due to reasons relating to the individual's other activities or precautions taken, designating an individual or group of individuals who will receive treatment, providing a strip, the strip having an effective amount of antimicrobial agent capable of being delivered transdermally, the strip is exteriorly applied to the nose of the designated individual or group of individuals so to allow the antimicrobial agent to pass through the nose to interact with the colony to suppress the colonization, or altogether eradicate the colony.

04-21-2011

20120067346

METHOD OF CONTROLLING THE PROPAGATION OF MRSA, STAPH AND OTHER INFECTIONS THAT COLONIZE IN THE NOSE - A method for reducing the spread of bacterial infections includes identifying a group of individuals at risk of an infection that colonizes in the nose, determining whether any individuals can be exclude, designating an individual or group of individuals who will receive treatment, providing a strip, the strip having an effective amount of antimicrobial agent capable of being delivered to the colony of bacteria in, on, and around the nose, the strip is applied to the nose of the individual or group so to allow the agent to migrate to eradicate the colony; in an embodiment, a surgical mask, or a similar mask that covers the nose and mouth, is provided, said mask having a portion of the mask that contacts the nose, and said portion containing an antimicrobial agent capable of being delivered to eradicate the colonization of bacteria within the nose.

03-22-2012

20120215204

METHOD OF CONTROLLING THE PROPAGATION OF MRSA, STAPH AND OTHER INFECTIONS THAT COLONIZE IN THE NOSE - A method for reducing the spread of bacterial infections includes identifying a group of individuals at risk of an infection that colonizes in the nose, determining whether any individuals can be exclude, designating an individual or group of individuals who will receive treatment, providing a strip, mask, and/or clip, the strip, mask, and/or clip having an effective amount of antimicrobial agent capable of being delivered to the colony of bacteria in, on, and around the nose, the strip, mask, and/or clip is applied to the nose of the individual or group so to allow the agent to migrate to eradicate the colony.

CHEMICAL COMPOUNDS - The invention is directed to pyrido[4,3-d]pyrimidin-5(6H)-one derivatives. Specifically, the invention is directed to compounds according to Formula I:

06-09-2011

20120208827

BENZIMIDAZOLES AS FATTY ACID SYNTHASE INHIBITORS - This invention relates to the use of benzimidazole derivatives for the modulation, notably the inhibition of the activity or function of fatty acid synthase (FAS). Suitably, the present invention relates to the use of benzimidazoles in the treatment of cancer.

FATTY ACID SYNTHASE INHIBITORS - This invention relates to spirocyclic piperidines according to Formula (I) and the use of spirocyclic piperidines for the modulation, notably the inhibition of the activity or function of fatty acid synthase (FAS). Suitably, the present invention relates to the use of spirocyclic piperidines in the treatment of cancer.

07-10-2014

Patent applications by Michael Lee Moore, Collegeville, PA US

M. Thomas Moore, Ephrata, PA US

Patent application number

Description

Published

20110078940

Single use hermetically sealing mousetrap with internal carbon dioxide killing mechanism - A single use, hermetically sealing mousetrap has a housing defining an enclosure that contains a killing mechanism which is accessible through a rotatably mounted door controlled by a spring-loaded door opening gear mechanism. Mounted to the bottom of the housing inside the enclosure is a spring-actuated setting axle and setting bar combination that is movable between a tripped position and a set position by manipulation of a setting handle positioned outside the enclosure. When the setting axle is moved to the set position, the door opening gear mechanism causes the door to open while tensioning a torsional door spring. A trip latch and bait pedal are configured to operate together to secure the setting bar in the set position, with subsequent movement of the bait pedal by a mouse serving to release the trip latch. When the trap is thereby triggered, the setting bar moves to the tripped position where it both activates the killing mechanism and releases the door opening gear mechanism. The tensioned door spring then closes the door and the killing mechanism kills the mouse. With the door closed, the enclosure is hermetically sealed with the dead mouse inside and the trap can be disposed of without any contact between the user and the carcass along with any parasites and pathogens associated therewith.

04-07-2011

Patrick M. Moore, Pittsburgh, PA US

Patent application number

Description

Published

20110135598

METHODS TO DIAGNOSE AND IMMUNIZE AGAINST THE VIRUS CAUSING HUMAN MERKEL CELL CARCINOMA - The present invention provides isolated or substantially purified polypeptides, nucleic acids, and virus-like particles (VLPs) derived from a Merkel cell carcinoma virus (MCV), which is a newly-discovered virus. The invention further provides monoclonal antibody molecules that bind to MCV polypeptides. The invention further provides diagnostic, prophylactic, and therapeutic methods relating to the identification, prevention, and treatment of MCV-related diseases.

06-09-2011

Patrick S. Moore, Pittsburgh, PA US

Patent application number

Description

Published

20090068211

IMMUNOGENICALLY-ENHANCED POLYPEPTIDES AND RELATED METHODS - Described herein are immunogenically-enhanced polypeptides, such as KSHV LANA1 polypeptides, related methods of eliciting an immune response to the polypeptides and related nucleotide sequences. Also described herein are novel polypeptides capable of inhibiting degradation and/or retarding synthesis of a protein when attached to or incorporated within that protein along with related methods and nucleotide sequences.

03-12-2009

20110311567

Immunogenically-Enhanced Polypeptides and Related Methods - Described herein are immunogenically-enhanced polypeptides, such as KSHV LANA1 polypeptides, related methods of eliciting an immune response to the polypeptides and related nucleotide sequences. Also described herein are novel polypeptides capable of inhibiting degradation and/or retarding synthesis of a protein when attached to or incorporated within that protein along with related methods and nucleotide sequences.

12-22-2011

20120269854

Method of Enhancing KSHV LANA1 Immunogenicity - An immunogenically-enhanced Kaposi sarcoma-associated herpesvirus latency-associated nuclear antigen 1 (“KSHV LANA1”) polypeptide and related methods of eliciting an immune response to KSHV LANA1 are provided. Also described herein is a novel polypeptide capable of inhibiting degradation of a protein or retarding synthesis of a protein when attached to or incorporated within that protein.

10-25-2012

20140037581

METHODS TO DIAGNOSE AND IMMUNIZE AGAINST THE VIRUS CAUSING HUMAN MERKEL CELL CARCINOMA - The present invention provides isolated or substantially purified polypeptides, nucleic acids, and virus-like particles (VLPs) derived from a Merkel cell carcinoma virus (MCV), which is a newly-discovered virus. The invention further provides monoclonal antibody molecules that bind to MCV polypeptides. The invention further provides diagnostic, prophylactic, and therapeutic methods relating to the identification, prevention, and treatment of MCV-related diseases.

02-06-2014

20150086535

Use of Survivin Antagonists in Polyomavirus-Related Disease - A method of treating a polyomavirus (+) cancer in which survivin is upregulated in a patient is provided, comprising administering to the patient a therapeutically effective amount of a composition that downregulates survivin expression or function in cells of the polyomavirus (+) cancer. A method of reducing growth of polyomavirus (+) cancer cells in which survivin is up-regulated is provided, comprising contacting the cells with an amount of a composition that downregulates survivin expression or function effective to reduce growth of the cells. Also provided is sepantronium salt, for use in treating a polyomavirus (+) cancer in which survivin is up-regulated.

03-26-2015

Patent applications by Patrick S. Moore, Pittsburgh, PA US

Peter Moore, Philadelphia, PA US

Patent application number

Description

Published

20090048406

PROCESS FOR PREPARING CONTINUOUSLY VARIABLE-COMPOSITION COPOLYMERS - A continuously variable composition copolymer is prepared in a reaction system, by (a) providing a reaction vessel comprising a first monomer composition; (b) providing a feed vessel comprising a second monomer composition; (c) initiating a polymerization reaction in the reaction vessel; (d) continuing the polymerization reaction during the gradual addition of the second monomer composition from the feed vessel to the reaction vessel, wherein the gradual addition of the second monomer composition is performed such that the continuously variable composition copolymer is obtained; (e) maintaining the polymerization until at least 90% of the total monomer composition has been converted to the copolymer; wherein the copolymer has a weight average molecular weight from 10,000 to 1,000,000; wherein the copolymer is soluble in lubricating oil, wherein the monomers of the first monomer composition provided in the reaction vessel comprise at least 50% by weight of all the monomers used to prepare the copolymer.

02-19-2009

Peter Moore, Glenside, PA US

Patent application number

Description

Published

20120302477

POLYMER USEFUL AS VISCOSITY INDEX IMPROVER - The present invention describes a polymer useful as viscosity index improver comprising units derived from one or more ethylenically unsaturated ester compounds of formula (I), where R is hydrogen or methyl, R

11-29-2012

20130199482

MOTOR HAVING IMPROVED PROPERTIES - The present invention describes a motor designed for Fuel compatibility comprising a lubricant composition comprises at least one ester group containing polymer having a high polarity.

08-08-2013

Richard I. Moore, Blue Bell, PA US

Patent application number

Description

Published

20150197261

MOBILE CART FOR SPRAY DISPENSING - A mobile cart includes a cart frame, wheels rotatably attached to the frame and feet projecting from the frame to an underlying support surface. A carrier tray is fixedly secured atop the cart frame, having a generally planar tray base, a front wall extending upwardly from the front end of the tray base and a cavity. A first container, containing a first material, and a second container, containing a second material, are positioned in the cavity. A combination mixer and dispenser is releasably secured to the frame and releasably fluidly coupled to the first and second containers. The cart is tiltable between a generally horizontal position and a generally vertical position. The front wall of the tray is angled from the tray base such that the front wall lies against the support surface in the generally vertical position, stabilizing the cart for container loading and unloading.

DIAGNOSIS OF SEPSIS - Methods and apparatus for predicting the development of sepsis in a subject at risk for developing sepsis are provided. Features in a biomarker profile of the subject are evaluated. The subject is likely to develop sepsis if these features satisfy a particular value set. Methods and apparatus for predicting the development of a stage of sepsis in a subject at risk for developing a stage of sepsis are provided. A plurality of features in a biomarker profile of the subject is evaluated. The subject is likely to have the stage of sepsis if these feature values satisfy a particular value set. Methods and apparatus for diagnosing sepsis in a subject are provided. A plurality of features in a biomarker profile of the subject is evaluated. The subject is likely to develop sepsis when the plurality of features satisfies a particular value set.

04-23-2009

20110105350

DIAGNOSIS OF SEPSIS - Methods for predicting the development of sepsis in a subject at risk for developing sepsis are provided. In one method, features in a biomarker profile of the subject are evaluated. The subject is likely to develop sepsis if these features satisfy a particular value set. Methods for predicting the development of a stage of sepsis in a subject at risk for developing a stage of sepsis are provided. In one method, a plurality of features in a biomarker profile of the subject is evaluated. The subject is likely to have the stage of sepsis if these feature values satisfy a particular value set. Methods of diagnosing sepsis in a subject are provided. In one such method, a plurality of features in a biomarker profile of the subject is evaluated. The subject is likely to develop sepsis when the plurality of features satisfies a particular value set.

05-05-2011

20110118569

Advanced Detection of Sepsis - The present invention relates to methods, monitors and systems measuring lysophosphatidylcholine, its derivatives and/or procalcitonin as well as at least one clinical marker (e.g. temperature or respiration rate) and/or at least one biomarker for the early detection of sepsis in a subject.

05-19-2011

20140141435

DIAGNOSIS OF SEPSIS - Methods for predicting the development of sepsis in a subject at risk for developing sepsis are provided. In one method, features in a biomarker profile of the subject are evaluated. The subject is likely to develop sepsis if these features satisfy a particular value set. Methods for predicting the development of a stage of sepsis in a subject at risk for developing a stage of sepsis are provided. In one method, a plurality of features in a biomarker profile of the subject is evaluated. The subject is likely to have the stage of sepsis if these feature values satisfy a particular value set. Methods of diagnosing sepsis in a subject are provided. In one such method, a plurality of features in a biomarker profile of the subject is evaluated. The subject is likely to develop sepsis when the plurality of features satisfies a particular value set.

05-22-2014

20140302533

ADVANCED DETECTION OF SEPSIS - The present invention relates to methods, monitors and systems, useful, for example, for advanced detection of sepsis in a subject.

10-09-2014

Patent applications by Richard L. Moore, Glenville, PA US

Robert Hunter Moore, Pittsburgh, PA US

Patent application number

Description

Published

20080264184

Wireless Sensors in Roll Covers - An industrial roll includes: a substantially cylindrical shell having an outer surface; a polymeric cover circumferentially overlying the shell outer surface; and a sensing system. The sensing system includes: a plurality of sensors embedded in the cover, each sensor configured to sense a data parameter; and a plurality of wireless transceivers, each transceiver connected to a respective sensor and embedded in the cover adjacent thereto. Each wireless transceiver is configured to transmit data signals from the respective sensor. Related methods and systems are also discussed.

10-30-2008

20090320612

Wireless Sensors in Roll Covers - An industrial roll includes: a substantially cylindrical shell having an outer surface; a polymeric cover circumferentially overlying the shell outer surface; and a sensing system. The sensing system includes: a plurality of sensors embedded in the cover, each sensor configured to sense a data parameter; and a plurality of wireless transceivers, each transceiver connected to a respective sensor and embedded in the cover adjacent thereto. Each wireless transceiver is configured to transmit data signals from the respective sensor. Related methods and systems are also discussed.

12-31-2009

20100125428

System and Method for Detecting and Measuring Vibration in an Industrial Roll - A system for determining the source of vibration of a nipped roll assembly includes: a first substantially cylindrical roll; a mating structure positioned relative to the first roll to form a nip therewith; a plurality of annular nip condition sensor units mounted on the first roll; each of the annular nip condition sensor units being positioned at different axial locations along the first roll and configured to provide nip condition signals from the nip, the signals indicating a nip condition at multiple circumferential locations; and a processor associated with the sensor units that receives signals from the sensor units. The processor is configured to convert the signals from the sensor units into nip condition readings for the multiple circumferential locations at each axial location. Such a system can detect irregularities in a roll or the mating structure that can cause undesired vibration.

05-20-2010

Patent applications by Robert Hunter Moore, Pittsburgh, PA US

Robin D. Moore, Yardley, PA US

Patent application number

Description

Published

20080262228

Metabolites of 5-fluoro-8- quinoline and methods of preparation and uses thereof - The present invention relates to novel metabolites of 5-Fluoro-8-{4-[4-(6-methoxyquinolin-8-yl)piperazin-1-yl]piperidin-1-yl}quinoline, which can be useful in treating CNS disorders. The present invention further relates to processes for their preparation, to pharmaceutical compositions comprising them, and to methods of using them.

10-23-2008

Rocky A. Moore, Dravosburg, PA US

Patent application number

Description

Published

20140141697

TOOL AND METHOD FOR MACHINING A DOVETAIL - Tools and methods for machining a dovetail are disclosed. The dovetail includes a plurality of tangs. In one embodiment, the tool includes a body and a plurality of mount brackets, each of the plurality of mount brackets connected to the body and positionable in contact with a crush surface of the dovetail. The tool further includes an engagement member connected to the body and adjustable such that contact by the engagement member with the dovetail forces each of the plurality of mount brackets against the associated crush surface. The tool further includes a machining assembly for machining one of the plurality of tangs of the dovetail, the machining assembly connected to the body.