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A police officer and the owner of a run-down Park Slope brownstone were injured after the landmarked building partially collapsed Friday morning, neighbors and authorities said.

The interior of the four-story row house caved in just before noon Friday, causing a responding police officer to fall through a hole in the floor and sending the injured owner into a frenzy, according to neighbors, who say the owner was led out in handcuffs after refusing to leave.

“She was resisting help,” said a neighbor, who asked not to be named.

Both the officer and the owner were taken to New York Methodist Hospital with minor injuries, a fire department spokesman said. Neighbors say the woman lives alone and has an open case with Adult Protective Services, a state agency serving physically and mentally impaired adults who are at risk of harm.

The residence was roped off with caution tape as of Friday night, according to neighbors. The Department of Buildings is investigating the structure. The fine has not yet been paid, according to the building department’s website.