..In conclusion, the concentrations of Cho, Cr and NAA are reduced in PPMS/SPMS patients, especially in GM and in WML. Despite contrary observations in previous studies, increases in the concentrations of Cr and/or Cho were not observed...

Paul E SijensDepartment of Radiology, University Medical Center Groningen and University of Groningen, The NetherlandsEur Radiol 16:898-904. 2006

..88; P<0.00001) than in GM (r=-0.69, P<0.01). The demonstrated relationship between DTI parameters and water content in multiple sclerosis patients suggests a potential for therapy monitoring in normal-appearing brain tissue...

P E SijensDepartment of Radiology, University Medical Center Groningen and University of Groningen, Groningen, The NetherlandsMol Genet Metab 88:285-9. 2006

..MR spectroscopy in two patients with glutaric aciduria type I revealed reductions in the white matter N-acetylaspartate signal, in the more severe case accompanied by a loss of glutamate and the appearance of lactate signals...

Impact of fluoxetine on the human brain in multiple sclerosis as quantified by proton magnetic resonance spectroscopy and diffusion tensor imaging

Paul E SijensDepartment of Radiology, University Hospital Groningen, and University of Groningen, The NetherlandsPsychiatry Res 164:274-82. 2008

..These preliminary results provide evidence of a neuroprotective effect of fluoxetine in MS by the observed partial normalization of the structure-related MRS parameter N-acetylaspartate in white matter lesions...

..It is concluded that the Gd-induced loss of tumor Cho signal measured after 5 min, typically required for post contrast-MRI and the positioning of the CSI volume on tumor, shows little further change with time, if any...

High cerebral guanidinoacetate and variable creatine concentrations in argininosuccinate synthetase and lyase deficiency: implications for treatment?

..It is indicated that the number of detected metastases will increase further at Gd doses beyond 0.3 mmol/kg. Post-Gd MRI contrast increases with lesion size, to an extent that can not be attributed to partial volume attenuation...

..Large reproducible differences were found in liver metabolite peak areas but not in pH, indicating that processing and peak integration methods can only explain part of the discrepancies between the results from different institutions...

..In this study long-term reproducibility of STIR image intensity was assessed under clinical conditions and the required image intensity nonuniformity correction was improved by using phantom scans obtained at multiple positions...

Quantitative multivoxel proton spectroscopy of the brain in developmental delay

..79; n=13; P=.001). It is concluded that in patients without inflammation and in patients with hematologic disease, the content of ferritin in blood is a better predictor of liver iron content than in other patient categories...

Magnetic resonance imaging and proton magnetic resonance spectroscopy of the brain in the diagnostic evaluation of developmental delay

..001). Even after correction of the algorithm, the problem remaining with the Dixon-based MRI method for the assessment of liver fat content,is that, at the lower end range, liver fat content is systematically overestimated by 4%...

..Best results were obtained at TE=135 ms, relating to the fact that at that particular TE, the visibility of a compound with a T2 of 215 ms still is good, while interfering signals from short-TE compounds are negligible...

..84 at the end of the second week (p=0.007). These findings show evidence for a reversible axonal dysfunction in patients with MS and provide a rationale for investigating whether fluoxetine has neuroprotective effects in MS...

..Compared to TSENSE, GRAPPA produced significantly better CNR on the first bolus. More consistent SNR and CNR were obtained from TSENSE images than from GRAPPA images, indicating that the diagnostic value of TSENSE may be better...

Phosphorus-31 chemical shift imaging of metastatic tumors located in the spine region

..Phosphorus-31 magnetic resonance spectroscopy was used in 14 cases to examine metastases of known malignant tumors located in the spine region. The purpose was to test the hypothesis that tumor phosphomonoester (PME) is elevated...

..Larger clinical studies are needed to confirm whether correlations of, for instance, pretreatment tumor pH with necrosis at resection and Pi decrease with tumor regression, can be used as a predictive test for clinical response...

..This suggests that the beneficial effects of rosiglitazone on liver metabolism are indirect and can be partly explained by increased suppression of nonesterified fatty acid levels, leading to reduced liver fat...