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You’re not sure how you got here, you’ll piece together the last 48 hours with Uber receipts. Oh and, naturally, you’ve spent the last few hours hugging the toilet.

Maybe you’ve been binge3ing on beer at a hen party/stag do, perhaps you’ve been chugging straight spirits from a concealed hipflask at a festival – or a bender might just be your Friday to Sunday routine.

‘In the short term, alcohol and late nights – though meant to be fun and stress relieving – are actually more likely to cause skin breakouts, anxiety and fatigue if done to excess, due to the lack of sleep.

‘Alcohol, when broken down by the body, creates toxins that although in time are excreted, create inflammatory reaction, making any sensitive areas of our body more susceptible to flare-up, especially the skin.’

Doctify gastroenterologist Dr Yiannis Kallis told Metro.co.uk: ‘A weekend of heavy drinking and drugs can take their toll on the body.

‘Common immediate effects include dehydration, salt imbalance and an erratic blood pressure, which often cause fatigue, headache, or muscle weakness.

‘Frequently, irritation to the lining of the gut can lead to nausea, heartburn, vomiting or diarrhoea. Rare but more serious consequences of an alcohol binge are an acute inflammation (swelling) of the liver or the pancreas, complications that are occasionally life-threatening.

‘In a worst-case scenario certain drugs such as cocaine and amphetamines can cause a heart attack, and others such as ecstasy can bring about a complete shutdown of vital organs such as the liver.’

Euan MacLennan, a medical herbalist who also works with the NHS, gave a more in-depth look at what alcohol consumption does to the body.

He told Metro.co.uk: ‘There is no single answer as to why a night of indulgence makes us feel so terrible the next morning.

‘Instead, it appears that a number of factors conspire to make us regret that last glass of Pinot Noir just before we left the bar.

The physiological effects of alcohol are myriad and compound.

So essentially, your hangover is a number of things ganging up on you when you’re feeling at your most pathetic. Oh good.

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MacLennan explains the contributing factors to a putrid hangover: ‘First, it acts as a diuretic by preventing us from secreting a substance called antidiuretic hormone (or vasopressin) from our posterior pituitary.

‘This means that we pass more water and become dehydrated, whilst also losing valuable electrolytes.’

So, drinking water during the night or before you go to sleep is a good idea to stave off the worst of this. Good luck and God speed.

‘Another issue is that the metabolism of alcohol by our liver produces a nasty by-product called acetaldehyde which can build up and basically acts as a toxin in our body.

‘If the liver’s detoxification pathways are overburdened, aldehydes can, instead of being converted to the next intermediate product, build up to harmful levels and cause damage as they are often more toxic than the original substances from which they are derived.’ he adds.

Essentially, bingeing is bad enough, regular binges are bad news.

Treat yo’self every now and again with a dry spell.

MacLennan also explains that hangover symptoms can differ in severity depending on what it was you drunk to get you into this mess.

He adds: ‘Alcoholic drinks also contain methanol.

The metabolism of methanol to formaldehyde and formic acid may be responsible for many hangover symptoms, such as trembling, nausea and fatigue.

‘People who are efficient ‘methanol metabolisers’ suffer more as they produce more by-products.

‘This is reinforced by the fact that certain types of drinks associated with more severe hangovers tend to contain higher levels of methanol.’

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‘Examples include cheap red wine, whiskey, brandy and other dark spirits. Whereas vodka and clear spirits are far lower in this compound.’