Credit

Ming-Hu Han, Ph.D., Mount Sinai School of Medicine

Description

Fiber optic stimulation mimicking high firing rates (vertical apparatus) of a key reward circuit hub (VTA) instantly converted genetically modified mice resilient to severe social stress into vulnerable animals. High firing rates in the circuit projection from VTA to NAc (and not from VTA to PFC) was found to be the main culprit in triggering depression related behaviors. Blocking the circuit in vulnerable mice instantly made them resilient.