Copyright in the material you requested is held by American College Of Physicians
(unless otherwise noted). This email ability is provided as a courtesy, and by using
it you agree that that you are requesting the material solely for personal, non-commercial
use, and that it is subject to ACP's Conditions of Use.
The information provided in order to email this topic will not be used to send unsolicited
email, nor will it be furnished to third parties. Please refer to
American College Of Physicians'sPrivacy
Policy for further information.

Disclaimer: Recommendations made by the USPSTF are independent of the U.S. government. They should not be construed as an official position of the Agency for Healthcare Research and Quality or the U.S. Department of Health and Human Services.

Financial Support: The USPSTF is an independent, voluntary body. The U.S. Congress mandates that the Agency for Healthcare Research and Quality support the operations of the USPSTF.

Abstract

This article has been corrected. For original version, click "Original Version (PDF)" in column 2.

Description:Update of the 2002 U.S. Preventive Services Task Force (USPSTF) recommendation on screening for osteoporosis.

Methods:The USPSTF evaluated evidence on the diagnostic accuracy of risk assessment instruments for osteoporosis and fractures, the performance of dual-energy x-ray absorptiometry and peripheral bone measurement tests in predicting fractures, the harms of screening for osteoporosis, and the benefits and harms of drug therapy for osteoporosis in women and men.

Recommendations:The USPSTF recommends screening for osteoporosis in women aged 65 years or older and in younger women whose fracture risk is equal to or greater than that of a 65-year-old white woman who has no additional risk factors. (Grade B recommendation)The USPSTF concludes that the current evidence is insufficient to assess the balance of benefits and harms of screening for osteoporosis in men. (I statement)

The U.S. Preventive Services Task Force (USPSTF) makes recommendations about preventive care services for patients without recognized signs or symptoms of the target condition.

It bases its recommendations on a systematic review of the evidence of the benefits and harms and an assessment of the net benefit of the service.

The USPSTF recognizes that clinical or policy decisions involve more considerations than this body of evidence alone. Clinicians and policymakers should understand the evidence but individualize decision making to the specific patient or situation.

Summary of Recommendations and Evidence

The USPSTF recommends screening for osteoporosis in women aged 65 years or older and in younger women whose fracture risk is equal to or greater than that of a 65-year-old white woman who has no additional risk factors. This is a B recommendation.

The USPSTF concludes that the current evidence is insufficient to assess the balance of benefits and harms of screening for osteoporosis in men. This is an I statement.

See the Clinical Considerations section for additional information about risk assessment for osteoporotic fractures and suggestions for practice regarding the I statement.

See the Figure for a summary of the recommendation and suggestions for clinical practice.

Rationale

Importance

By 2012, approximately 12 million Americans older than 50 years are expected to have osteoporosis. One half of all postmenopausal women will have an osteoporosis-related fracture during their lifetime; 25% of these women will develop a vertebral deformity, and 15% will experience a hip fracture. Osteoporotic fractures, particularly hip fractures, are associated with chronic pain and disability, loss of independence, decreased quality of life, and increased mortality. Although hip fractures are less common in men than in women, more than one third of men who experience a hip fracture die within 1 year.

Detection

The USPSTF found convincing evidence that bone measurement tests predict short-term risk for osteoporotic fractures in women and men. The most commonly used tests are dual-energy x-ray absorptiometry (DXA) of the hip and lumbar spine and quantitative ultrasonography of the calcaneus. Adequate evidence indicates that clinical risk assessment instruments have only modest predictive value for low bone density or fractures.

Benefits of Detection and Early Intervention

No controlled studies have evaluated the effect of screening for osteoporosis on fracture rates or fracture-related morbidity or mortality.

In postmenopausal women who have no previous osteoporotic fractures, the USPSTF found convincing evidence that drug therapies reduce the risk for fractures. In women aged 65 years or older and in younger women whose fracture risk is equal to or greater than that of a 65-year-old white woman who has no additional risk factors, the USPSTF judged that the benefit of treating screening-detected osteoporosis is at least moderate.

Because of the lack of relevant studies, the USPSTF found inadequate evidence that drug therapies reduce the risk for fractures in men who have no previous osteoporotic fractures. The USPSTF identified the absence of randomized trials of primary fracture prevention in men who have osteoporosis as a critical gap in the evidence.

Harms of Detection and Early Intervention

The USPSTF found no new studies that described harms of screening for osteoporosis in men or women. Screening with DXA is associated with opportunity costs (time and effort required by patients and the health care system). Harms of drug therapies for osteoporosis depend on the specific medication used. The USPSTF found adequate evidence that the harms of bisphosphonates, the most commonly prescribed therapies, are no greater than small. Convincing evidence indicates that the harms of estrogen and selective estrogen receptor modulators are small to moderate.

USPSTF Assessment

The USPSTF concludes that for women aged 65 years or older and younger women whose fracture risk is equal to or greater than that of a 65-year-old white woman who has no additional risk factors, there is moderate certainty that the net benefit of screening for osteoporosis by using DXA is at least moderate.

The USPSTF concludes that for men, evidence of the benefits of screening for osteoporosis is lacking and the balance of benefits and harms cannot be determined.

Clinical Considerations

Patient Population Under Consideration

This recommendation applies to older adults in the general U.S. population who do not have a history of an osteoporotic fracture, osteoporosis secondary to another condition, or other specific clinical indications for bone measurement testing. The USPSTF did not define a specific upper age limit for screening in women because the risk for fractures continues to increase with age and treatment harms remain no greater than small. Clinicians should take into account the patient's remaining lifespan when deciding whether to screen patients with significant illness. In the Fracture Intervention Trial (1), the benefit of treatment emerged 18 to 24 months after initiation of treatment.

The quantity and quality of data on osteoporotic fracture risk other than hip fracture are much lower for Asian, American Indian or Alaska Native, Hispanic, and black women than for white women. The USPSTF recommendation to screen women aged 65 years or older for osteoporosis applies to all racial and ethnic groups because the harms of the screening tests are no greater than small, the consequences of failing to identify and treat women who have low bone mineral density (BMD) are considerable, and the optimal alternative age at which to screen nonwhite women is uncertain.

Assessment of Risk

Multiple instruments to predict risk for low BMD and fractures have been developed and validated for use in postmenopausal women, but few have been validated for use in men. To predict fracture risk, the area under the receiver-operating characteristic curve ranges from 0.48 to 0.89 (2). Less complex instruments (those with fewer variables) seem to perform as well as more complex ones (3). The USPSTF found no studies that assessed the effect on patient outcomes of using risk prediction instruments alone or in combination with bone measurement tests.

The USPSTF used the FRAX (Fracture Risk Assessment) tool (World Health Organization Collaborating Centre for Metabolic Bone Diseases, Sheffield, United Kingdom; www.shef.ac.uk/FRAX/) to estimate 10-year risk for fractures because this tool relies on easily obtainable clinical information, such as age, body mass index (BMI), parental fracture history, and tobacco and alcohol use; its development was supported by a broad international collaboration and extensively validated in 2 large U.S. cohorts; and it is freely accessible to clinicians and the public. The FRAX tool includes questions about previous DXA results but does not require this information to estimate fracture risk.

On the basis of the U.S. FRAX tool, a 65-year-old white woman with no other risk factors has a 9.3% 10-year risk for any osteoporotic fracture. White women aged 50 to 64 years with equivalent or greater 10-year fracture risks based on specific risk factors include but are not limited to the following persons: 1) a 50-year-old current smoker with a BMI less than 21 kg/m2, daily alcohol use, and parental fracture history; 2) a 55-year-old woman with parental fracture history; 3) a 60-year-old woman with a BMI less than 21 kg/m2 and daily alcohol use; and 4) a 60-year-old current smoker with daily alcohol use. The FRAX tool also predicts 10-year fracture risks for black, Asian, and Hispanic women in the United States. In general, estimated fracture risks in nonwhite women are lower than those for white women of the same age.

Although the USPSTF recommends using a 10-year fracture risk threshold of 9.3% to screen women aged 50 to 64 years, clinicians also should consider each patient's values and preferences and use clinical judgment when discussing screening with women in this age group. Menopausal status is one factor that may affect a decision about screening in this age group.

Considerations for Practice Regarding the I Statement

When deciding whether to screen men for osteoporosis, clinicians should consider the following factors.

Potential Preventable Burden

Bone measurement tests may detect osteoporosis in a large number of men and prevent a substantial part of the burden of fractures and fracture-related illness in this population. The aging of the U.S. population is likely to increase this potentially preventable burden in future years.

Potential Harms

Potential harms of screening men are likely to be small and consist primarily of opportunity costs.

Current Practice

Routine screening of men currently is not a widespread practice.

Costs

Many additional DXA scanners may be required to screen sizeable populations of men for osteoporosis; the cost of DXA machines ranges from $25 000 to $85 000.

Assuming that the relative benefits and harms of therapy in men are similar to those in women, the men most likely to benefit from screening would have 10-year risks for osteoporotic fracture equal to or greater than those of 65-year-old white women who have no additional risk factors. However, current evidence is insufficient to assess the balance of benefits and harms of screening for osteoporosis in men.

Screening Tests

The most commonly used bone measurement tests used to screen for osteoporosis are DXA of the hip and lumbar spine and quantitative ultrasonography of the calcaneus. Quantitative ultrasonography is less expensive and more portable than DXA and does not expose patients to ionizing radiation. Quantitative ultrasonography of the calcaneus predicts fractures of the femoral neck, hip, and spine as effectively as DXA. However, current diagnostic and treatment criteria for osteoporosis rely on DXA measurements only, and criteria based on quantitative ultrasonography or a combination of quantitative ultrasonography and DXA have not been defined.

Screening Intervals

The potential value of rescreening women whose initial screening test did not detect osteoporosis is to improve fracture risk prediction. Evidence is lacking about optimal intervals for repeated screening and whether repeated screening is necessary in a woman with normal BMD. Because of limitations in the precision of testing, a minimum of 2 years may be needed to reliably measure a change in BMD; however, longer intervals may be necessary to improve fracture risk prediction. A prospective study of 4124 women aged 65 years or older found that neither repeated BMD measurement nor the change in BMD after 8 years was more predictive of subsequent fracture risk than the original measurement (4).

Treatment

In addition to adequate calcium and vitamin D intake and weight-bearing exercise, multiple drug therapies are approved by the U.S. Food and Drug Administration to reduce fractures, including bisphosphonates, parathyroid hormone, raloxifene, and estrogen. The choice of therapy should be an individual one based on the patient's clinical situation and the tradeoff between benefits and harms. Clinicians should educate patients on how to use drug therapies to minimize adverse effects. For example, esophageal irritation from bisphosphonate therapy can be reduced by taking the medication with a full glass of water and by not lying down for at least 30 minutes afterward.

Other Approaches to Prevention

The USPSTF has updated its evidence review on fall prevention in older adults and plans to issue an updated recommendation; in future months, the USPSTF also will issue a separate statement on the preventive effects of vitamin D and calcium supplements on osteoporotic fractures. When complete, these documents will be made available at www.uspreventiveservicestaskforce.org.

Useful Resources

The 10-year risk for osteoporotic fractures can be calculated for individuals by using the FRAX tool and could help to guide screening decisions for women younger than 65 years.

Summary guides for clinicians and patients on fracture prevention treatments for postmenopausal women who have osteoporosis are available from the Agency for Healthcare Research and Quality at http://effectivehealthcare.ahrq.gov. The recommendations in these guides may differ from those of the USPSTF because they were based on a systematic review that pooled data from trials that included women who had previous clinical fractures.

Other Considerations

Research Needs and Gaps

Given the absence of direct evidence that screening for osteoporosis reduces fracture-related morbidity or mortality, studies of long-term health outcomes of screened and nonscreened population groups are important. Research is needed to test the effectiveness of drug therapies for osteoporosis in men who do not have a history of fractures. The results of ongoing randomized trials of bisphosphonates for fracture prevention in men at high risk for fractures could help to assess whether these drugs are effective in men. Research to evaluate the outcome of screening women during periods of rapid bone loss (for example, menopause) also should be supported.

Further research that would inform clinical decisions about screening for osteoporosis include studies to establish parameters for treatment using quantitative ultrasonography as a primary screening test for osteoporosis, studies that ascertain the true incidence of major osteoporotic fractures in nonwhite ethnic groups in the United States, studies clarifying optimal screening intervals, and studies of the effect of clinical and subclinical vertebral fractures on health-related quality of life.

Discussion

Burden of Disease

Osteoporosis is characterized by low BMD and a resultant increased risk for fractures. It is estimated that as many as 1 in 2 women and 1 in 5 men are at risk for an osteoporosis-related fracture during their lifetime (5). Osteoporosis is more common in women than men and is more common in white persons than in any other racial group.

For all demographic groups, the rates of osteoporosis increase with age (2). Elderly patients have increased susceptibility to fractures because they commonly have additional risk factors for fractures, such as poor bone quality and an increased tendency to fall. Hip fractures in particular can result in significant morbidity and mortality. Fractures at other sites also can lead to significant illness, causing chronic pain or disability and negatively affecting functional ability and quality of life. Direct medical care costs of osteoporotic fractures were estimated to be $12.2 to $17.9 billion per year in 2002 U.S. dollars (5); these estimates do not include indirect costs associated with lost productivity of patients and caregivers.

The burden of osteoporosis varies according to age and other risk factors. Many different risk assessment instruments have been developed to predict risk for low BMD or fractures. Multiple studies have validated these tools; however, few of these studies have included men. Despite various risk factors and variables included in the different risk assessment tools, none of the tools has consistently superior performance (3).

The FRAX tool, developed by the World Health Organization and the National Osteoporosis Foundation, is one of the most widely used instruments to predict risk for fractures. This tool was derived from data on 9 cohorts in Europe, Canada, the United States, and Japan. Seven of these cohorts included men. The FRAX tool was validated in 11 cohorts, but only 1 of these cohorts included men (6).

Because a large and diverse sample was used to develop and validate the FRAX tool and this instrument includes a publicly available risk calculator, the USPSTF used the FRAX tool to determine which individuals would exceed the baseline risk threshold for fractures on the basis of their age or other risk factors (such as low BMI, parental history of hip fracture, smoking status, and daily alcohol use). Considering a 65-year-old white woman who has no other risk factors to be the baseline risk case (a 10-year risk for any osteoporotic fracture of 9.3%), women as young as 50 years may have a 10-year risk for any osteoporotic fracture of 9.3% or greater, depending on the type and number of risk factors present (2).

Scope of Review

This update addressed critical gaps in the evidence identified in the 2002 USPSTF recommendation and expanded the scope of the previous review by evaluating screening and treatment for osteoporosis in men as well as women. The USPSTF defined the screening population as postmenopausal women and older men who have no known previous osteoporotic fractures or secondary causes of osteoporosis. Persons who have fractures or secondary causes of osteoporosis would undergo bone density testing as diagnostic tests, not screening tests.

Key questions in this review included how screening for osteoporosis affects fracture rates and fracture-related morbidity and mortality, the harms of screening for osteoporosis, the diagnostic accuracy of risk assessment instruments for low BMD and fractures, the performance of DXA and peripheral bone measurement tests in predicting fractures, and the benefits and harms of drug therapy to reduce fractures in women and men who have no known previous fractures.

Accuracy of Screening Tests

DXA

Measurement of bone density using DXA has become the gold standard for the diagnosis of osteoporosis and for guiding decisions about which patients to treat. Although it is not a perfect predictor of fractures, DXA of the femoral neck is considered the best predictor of hip fracture and is comparable with DXA measurements of the forearm for predicting fractures at other sites (7). Previous studies evaluating the accuracy of DXA for predicting fractures have focused mainly on women; studies have only recently assessed the predictive ability of DXA in men. A large prospective cohort study in the Netherlands that included men and women older than 55 years reported the incidence of vertebral and nonvertebral fractures approximately 6 years after baseline DXA measurements of the femoral neck were obtained. For each SD reduction in BMD at the femoral neck, the hazard ratio for vertebral and nonvertebral fractures increased to a similar degree in both men and women (6–7). Other studies of the performance of DXA in men have reported similar findings (3).

Quantitative Ultrasonography

The most commonly used test in the United States after DXA is quantitative ultrasonography of the calcaneus. Quantitative ultrasonography is less expensive than DXA, does not involve radiation, and can feasibly be implemented in primary care settings. Recent studies demonstrate that quantitative ultrasonography of the calcaneus can predict fractures as effectively as DXA in postmenopausal women and in men.

Quantitative ultrasonography seems to be equivalent to DXA for predicting fractures and has other potential advantages, but also a few distinct disadvantages. The current diagnostic criteria for osteoporosis use DXA measurements as cutoffs, and the measurements obtained from quantitative ultrasonography are not interchangeable with those obtained from DXA. Also, all trials evaluating drug therapies for osteoporosis use DXA measurements as inclusion criteria. Thus, for quantitative ultrasonography to be relevant and clinically useful, a method for converting or adapting results of quantitative ultrasonography to the DXA scale will need to be developed.

One meta-analysis examined 25 studies to assess the accuracy of quantitative ultrasonography compared with DXA in identifying patients with osteoporosis. When various quantitative ultrasonography index parameter cutoffs were used, the results varied widely in sensitivity and specificity for identifying individuals with a T-score of −2.5 or less on DXA. No quantitative ultrasonography cutoff existed at which sensitivity and specificity were both high (8).

Effectiveness of Early Detection and Treatment

No controlled studies have evaluated the effect of screening for osteoporosis on rates of fractures or fracture-related morbidity or mortality.

Drug therapies for osteoporosis can be for primary prevention (prevention of an osteoporotic fracture in patients with low BMD who have no previous fractures) or secondary prevention (prevention of an osteoporotic fracture in patients who have a known previous osteoporotic fracture). Primary prevention trials are more applicable to the screening population addressed in this recommendation. For the purposes of the USPSTF evidence review, primary prevention studies were defined as trials that 1) excluded patients who had previous vertebral or other osteoporotic fractures; 2) admitted patients who had previous osteoporotic fractures, if the number of these patients constituted less than 20% of the overall sample; 3) reported results separately for patients who did and did not have previous fractures; or 4) did not report the proportion of patients who had previous osteoporotic fractures, if the trial did not select patients on the basis of whether they had a previous fracture and included patients whose mean BMD T-score was no worse than −3.0 (2).

Drug therapies include bisphosphonates, parathyroid hormone, raloxifene, estrogen, and calcitonin. For primary prevention in postmenopausal women, bisphosphonates, parathyroid hormone, raloxifene, and estrogen have been shown to reduce vertebral fractures. The evidence is strongest and most consistent for bisphosphonates and raloxifene (2).

In a meta-analysis of 7 trials, the relative risk (RR) for vertebral fractures for bisphosphonates compared with placebo was 0.66 (95% CI, 0.50 to 0.89). Two large placebo-controlled trials of raloxifene reported reduced vertebral fractures, with a combined RR for raloxifene of 0.61 compared with placebo (CI, 0.55 to 0.69) (9). A pooled analysis of 9 trials demonstrated a non–statistically significant trend toward a reduction in nonvertebral fractures with bisphosphonates compared with placebo (RR, 0.83 [CI, 0.64 to 1.08]) (3). In the largest trial of bisphosphonates, the Fracture Intervention Trial of alendronate, fractures were significantly reduced only in women with baseline femoral neck T-scores less than −2.5 (1).

Evidence of the effectiveness of treatment of osteoporosis in men is limited. There are no primary prevention trials of bisphosphonates in men and only 2 secondary prevention trials of alendronate. When the 2 trials were pooled, alendronate was associated with a reduced risk for vertebral fractures (odds ratio [OR], 0.35 [CI, 0.17 to 0.77]), and the effect on nonvertebral fractures was not statistically significant (OR, 0.73 [CI, 0.32 to 1.67]) (10). A single primary prevention trial of parathyroid hormone reported a non–statistically significant trend toward a reduction in vertebral and nonvertebral fractures (11). None of the other therapies for osteoporosis in men has been evaluated in randomized trials.

Potential Harms of Screening and Treatment

Potential harms of screening for osteoporosis include false-positive test results causing unnecessary treatment, false-negative test results, and patient anxiety about positive test results. No studies that addressed the potential harms of screening were identified during this review.

The harms of drug therapy for osteoporosis have been studied most extensively for bisphosphonates, raloxifene, and estrogen. For bisphosphonates, the evidence demonstrates no definitive increase in the risk for serious gastrointestinal adverse events (for example, perforations, ulcers, bleeding, esophagitis, or esophageal ulceration) in persons who use these medications appropriately. The evidence on the risk for atrial fibrillation with bisphosphonates is conflicting. One large case–control study in Denmark showed an increased risk for atrial fibrillation with any use of alendronate compared with no use of this agent (OR, 1.86 [CI, 1.09 to 3.15]) (12), but a smaller case–control study in Washington showed no increased risk for atrial fibrillation with any use of etidronate (RR, 0.95 [CI, 0.84 to 1.07]) or any use of alendronate (RR, 1.04 [CI, 0.90 to 1.21]) (13) compared with no use of either agent.

Osteonecrosis of the jaw has been associated with bisphosphonates in case reports, but this condition typically develops in patients with cancer who receive higher doses than those normally used for osteoporosis treatment or prevention. Case reports also have described severe musculoskeletal symptoms associated with all of the bisphosphonates (2). In October 2010, the U.S. Food and Drug Administration issued a warning about a possible elevated risk for midfemur fractures in patients receiving bisphosphonates, especially for patients who have received them for more than 5 years.

Raloxifene and estrogen are associated with higher rates of thromboembolic events than placebo. Estrogen increases the risk for stroke, and estrogen with progestin increases the risk for coronary heart disease and breast cancer (2). Evidence is limited on the harms associated with use of calcitonin and parathyroid hormone for osteoporosis.

Estimate of Magnitude of Net Benefit

The USPSTF found convincing evidence that drug therapies reduce subsequent fracture rates in postmenopausal women. For women aged 65 years or older and younger women who have similar estimates of fracture risk, the benefit of treating screening-detected osteoporosis is at least moderate. The harms of treatment were found to range from no greater than small for bisphosphonates and parathyroid hormone to small to moderate for raloxifene and estrogen. Therefore, the USPSTF concludes with moderate certainty that the net benefit of screening for osteoporosis in this group of women is at least moderate.

For men, the USPSTF concludes that evidence is inadequate to assess the effectiveness of drug therapies in reducing subsequent fracture rates in men who have no previous fractures. Treatments that have been proven effective in women cannot necessarily be presumed to have similar effectiveness in men. Thus, the USPSTF could not assess the balance of benefits and harms of screening for osteoporosis in men.

How Does Evidence Fit With Biological Understanding?

Low bone density is a risk factor for fractures, especially in elderly persons. Screening and treating low BMD detected through screening can result in increased BMD and decrease the risk for subsequent fractures and fracture-related morbidity and mortality. Most evidence supports screening and treatment of osteoporosis in postmenopausal women; the evidence for primary prevention in men is lacking, and future research is needed. It cannot be assumed that the bones of men and women are biologically the same, especially because bone density is affected by the differing levels and effects of testosterone and estrogen in men and women. Moreover, rapid bone loss occurs in women because of the loss of estrogen during menopause. Although this offers a plausible explanation for why women have a higher risk for osteoporosis at an earlier age than men, it raises the question of whether the benefits of treatment observed in trials of women can be directly extrapolated to men.

Response to Public Comments

A draft version of this recommendation statement was posted for public comment on the USPSTF Web site from 5 July through 4 August 2010. Many comments pointed out a lack of clarity about how clinicians can estimate 10-year fracture risks in women aged 50 to 64 years to determine whether they should receive screening for osteoporosis. Also, some comments requested specific recommendations about the age at which to begin screening in men and optimal intervals for screening. In response to these comments, the USPSTF clarified its approach to fracture risk assessment by revising and expanding the Clinical Considerations section. In the Research Needs and Gaps section, the USPSTF highlighted the types of studies that are needed to fill the evidence gaps about screening for osteoporosis in men and screening intervals.

Update of Previous USPSTF Recommendation

This recommendation replaces the 2002 recommendation. The major change in the current recommendation is that the USPSTF now recommends screening all women whose 10-year fracture risk is equal to or greater than that of a 65-year-old white woman who has no additional risk factors. In addition, the current recommendation addresses screening for osteoporosis in men.

Recommendations of Others

The National Osteoporosis Foundation recommends bone density testing for all women aged 65 years or older and all men aged 70 years or older. It also recommends bone density testing for postmenopausal women younger than 65 years and men aged 50 to 69 years if there is concern about osteoporosis on the basis of their risk factor profile (14). According to the World Health Organization, there is indirect evidence of the effectiveness of screening for osteoporosis in women aged 65 years or older, but no direct scientific evidence supports widespread screening for osteoporosis using BMD testing. Moreover, widespread screening programs may not be feasible or cost-effective in many countries (15).

The American College of Physicians recommends that clinicians assess older men for osteoporosis risk factors and use DXA to screen men at increased risk who are candidates for drug therapy for osteoporosis (16). Previous statements by the American Academy of Family Physicians about screening for osteoporosis have been consistent with those of the USPSTF, and it is currently updating its recommendations. Finally, the American Congress of Obstetricians and Gynecologists recommends screening all women aged 65 years or older with BMD testing and screening postmenopausal women younger than 65 years who have 1 or more risk factors for osteoporosis (17). Table 3 shows a summary of these recommendations.

U.S. Department of Health and Human Services. Bone Health and Osteoporosis: A Report of the Surgeon General. Rockville, MD: U.S. Department of Health and Human Services Office of the Surgeon General; 2004.

Kanis JA,Oden A,Johnell O,Johansson H,DeLaet C,Brown J. et al. The use of clinical risk factors enhances the performance of BMD in the prediction of hip and osteoporotic fractures in men and women. Osteoporos Int. 2007; 18:1033-46.
PubMed

Qaseem A,Snow V,Shekelle P,Hopkins R Jr,Forciea MA,Owens DK,Clinical Efficacy Assessment Subcommittee of the American College of Physicians. Screening for osteoporosis in men: a clinical practice guideline from the American College of Physicians. Ann Intern Med. 2008; 148:680-4.
PubMed

U.S. Department of Health and Human Services. Bone Health and Osteoporosis: A Report of the Surgeon General. Rockville, MD: U.S. Department of Health and Human Services Office of the Surgeon General; 2004.

Kanis JA,Oden A,Johnell O,Johansson H,DeLaet C,Brown J. et al. The use of clinical risk factors enhances the performance of BMD in the prediction of hip and osteoporotic fractures in men and women. Osteoporos Int. 2007; 18:1033-46.
PubMed

Qaseem A,Snow V,Shekelle P,Hopkins R Jr,Forciea MA,Owens DK,Clinical Efficacy Assessment Subcommittee of the American College of Physicians. Screening for osteoporosis in men: a clinical practice guideline from the American College of Physicians. Ann Intern Med. 2008; 148:680-4.
PubMed

Comments

Please read the other comments before posting. Contributors must reveal any conflict
of interest.
Comments are moderated and will appear on the site at the discretion of The American
College of Physicians editorial staff. Please be sure your email address is
updated in your account, otherwise the American College of Physicians will not be
able to contact you about your comment.

* = Required Field

Comment Author(s)* (if multiple authors,
separate names by comma)

Example: John Doe

Affiliation & Institution*

Disclosure of Any Conflicts of Interest*
(applies to the past 5 years and foreseeable future) Indicate any potential conflicts
of interest of each author below, including specific financial interests and relationships
and affiliations relevant to the subject matter or materials discussed in the manuscript
(eg, employment/affiliation, grants or funding, consultancies, honoraria, speakers
bureau, stock ownership or options, expert testimony, royalties, donation of medical
equipment, or patents filed, received, or pending). If all authors have none, check
"No potential conflicts or relevant financial interests" in the box below. Please
also indicate any funding received in support of this work. The information will
be posted with your response.

Supplements

Summary for Patients

The full report is titled “Screening for Osteoporosis: U.S. Preventive Services Task Force Recomm-endation Statement.” It is in the 1 March 2011 issue of Annals of Internal Medicine (volume 154, pages 356-364). The author is the U.S. Preventive Services Task Force.

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College
of Physicians (ACP). All text, graphics, trademarks, and other intellectual property
incorporated into the slide sets remain the sole and exclusive property of the ACP.
The slide sets may be used only by the person who downloads or purchases them and
only for the purpose of presenting them during not-for-profit educational activities.
Users may incorporate the entire slide set or selected individual slides into their
own teaching presentations but may not alter the content of the slides in any way
or remove the ACP copyright notice. Users may make print copies for use as hand-outs
for the audience the user is personally addressing but may not otherwise reproduce
or distribute the slides by any means or media, including but not limited to sending
them as e-mail attachments, posting them on Internet or Intranet sites, publishing
them in meeting proceedings, or making them available for sale or distribution in
any unauthorized form, without the express written permission of the ACP. Unauthorized
use of the In the Clinic slide sets will constitute copyright infringement.