Clinical Interests

Research Interests

Dr. Deborah Rubin’s laboratory focuses on understanding mechanisms that regulate gut stem and crypt epithelial cell proliferation in normal intestine and in inflammation-induced colon cancer. Our studies have relevance to human short bowel syndrome and colitis-associated colon cancer. We are studying the role of myofibroblasts in the crypt stem cell niche and in inflammation induced carcinogenesis . These cells have important effects on proliferation of the gut epithelium or cellular lining, in both the normal intestine and in the inflamed intestine. Our lab, in collaboration with Dr. Marc Levin’s laboratory, has also had a long-standing interest in studying the molecular basis for enhanced gut proliferation in response to loss of small bowel surface area in short bowel syndrome. Recent studies focus on the role of luminal contents such as diet and microbiome on the adaptive response in short bowel syndrome.

Research Interest

Dr. Deborah Rubin’s laboratory focuses on understanding mechanisms that regulate gut stem and crypt epithelial cell proliferation in normal intestine and in inflammation-induced colon cancer. Our studies have relevance to human short bowel syndrome and colitis-associated colon cancer. We are studying the role of myofibroblasts in the crypt stem cell niche and in inflammation induced carcinogenesis . These cells have important effects on proliferation of the gut epithelium or cellular lining, in both the normal intestine and in the inflamed intestine. Our lab, in collaboration with Dr. Marc Levin’s laboratory, has also had a long-standing interest in studying the molecular basis for enhanced gut proliferation in response to loss of small bowel surface area in short bowel syndrome. Recent studies focus on the role of luminal contents such as diet and microbiome on the adaptive response in short bowel syndrome.