PREDICELLTM kits enable interaction studies with drug uptake transporters. The kits contain transfected as well as parental control cells on tissue culture plates. Transporter interactions are detected through changes in accumulation inside the cells.

The assays are available as:

96-well kit for inhibition studies

24-well kit for direct uptake studies (substrate assessment)

Benefits

With the PREDICELLTM Kits SOLVO aims to provide access to uptake transporters

if you prefer in-house studies

if you do not have cell culturing capacities

if you do not plan to acquire or develop cell lines

In the box

Plates with cells

User’s Manual with sample transport assay protocol

Product data sheet

Optional reagents

Thermal and mechanical insulation

Additional reagents to conduct a study straight out of the box can be included upon request..

Technical aspects

Standard timeline comprises seeding on Monday, Kit assembly and dispatch on Tuesday and delivery on Wednesday or Thursday (depending on your location). Studies may be conducted within 24 hours upon delivery. Alternative schedules are possible upon request.

One 30x30x40 cm box contains up to five plates, documentation and optional reagents.

During shipment, the activity of uptake transporters in the PREDICELLTM Kit remains stable during shipment for 48 hours, as shown in Figure 1.

Figure 1.: Testing insulation capabilities of the packaging in a 4°C refrigerator. Estrone-3-sulfate uptake activity of OATP1B1 trasfected cells and TEA uptake activity of OCT1 cells were tested on packaged cells put into the refrigerator as well as control cells kept in incubator.