New stem cell treatment 'halts' effects of multiple sclerosis

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Photos:Famous people with multiple sclerosis

TV personality Jack Osbourne was diagnosed with MS in 2012, just weeks after the birth of his daughter.

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Photos:Famous people with multiple sclerosis

"Sopranos" actress Jamie-Lynn Sigler, 34, revealed that she has multiple sclerosis in People magazine. She told the magazine she was diagnosed with the disease when she was 20.

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NASCAR driver Trevor Bayne announced that he was diagnosed in 2013. The chronic disease affects the central nervous system, often causing pain, numbness in the limbs and a loss of vision.

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Actress Teri Garr was diagnosed with multiple sclerosis in 1999. Garr might be best known for her roles in the iconic 1980s films "Mr. Mom" and "Tootsie."

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It has been more than 15 years since musician Clay Walker was diagnosed with multiple sclerosis. He says he's learned to manage his condition by eating a healthy diet, exercising and taking his medication.

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Josh Harding, formerly a goaltender with the NHL's Minnesota Wild, was diagnosed with MS at the age of 28.

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Singer Alan Osmond, left, and his son David Osmond both live with multiple sclerosis.

Talk-show host Montel Williams was diagnosed with multiple sclerosis in 1999. Williams said then that he had been misdiagnosed for 10 years.

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Noah "40" Shebib, a Canadian hip-hop producer who has collaborated with artists such as Drake and Lil Wayne, was diagnosed with multiple sclerosis in his early 20s.

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Photos:Famous people with multiple sclerosis

David Lander, left, who played Squiggy on TV's "Laverne & Shirley," hid his diagnosis for 15 years "primarily because I didn't think show business would embrace the fact that I have a chronic disease known as multiple sclerosis," he said in a 2001 interview with CNN.

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Ann Romney, wife of former presidential candidate Mitt Romney, was diagnosed with MS in 1998.

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Ten years ago, singer Tamia Hill was diagnosed with multiple sclerosis. She has recorded four albums since.

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Chris Wright was the first-known NBA player with multiple sclerosis. The former Dallas Maverick now plays professionally in Israel.

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Story highlights

A trial uses an aggressive form of chemotherapy to treat multiple sclerosis

Most patients ceased development of new brain lesions, but one died from the treatment

(CNN)Chemotherapy, combined with stem cell transplants, could halt the onslaught of multiple sclerosis in people suffering from the disease, according to a new study.

The treatment involved using an aggressive form of chemotherapy to destroy the immune system and then rebuild it using stem cells taken from the patient's blood. It was carried out on 24 patients across three Canadian hospitals.

Multiple sclerosis is a chronic inflammatory disease affecting the central nervous system and is caused when the immune system attacks the body, known as autoimmunity.

The use of newly grown immune cells transplanted into patients would mean they would not have developed the defects that would cause them to attack.

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The patients -- between 18 and 50 years old -- had disabilities ranging from moderate MS symptoms to requiring a walking aid.

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In 23 of the patients, the treatment halted the development of new brain lesions, without the need for ongoing medication.

Eight of the patients also had a sustained improvement in their disabilities 7½ years after treatment, according to research published in the British medical journal The Lancet. However, one of the patients died from the effects of chemotherapy.

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Dr. Mark Freedman, who helped conduct the trial and was one of the authors of the report, admitted that the sample size of patients was very small, with no control group for comparison.

"Since this is an aggressive treatment, the potential benefits should be weighed against the risks of serious complications associated with aHSCT [autologous haematopoietic stem cell transplant]," he said in a statement.

"This treatment should only be offered in specialist centers experienced both in multiple sclerosis treatment and stem cell therapy, or as part of a clinical trial."

Dr. Emma Gray, head of clinical trials at the UK's MS Society, was cautious about the findings.

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"This treatment does offer hope, but it's also an aggressive procedure that comes with substantial risks and requires specialist aftercare," she said in a statement.

"If anyone is considering aHSCT we'd recommend they speak to their neurologist."

Professor Siddharthan Chandran, director of the Centre for Clinical Brain Sciences at Edinburgh University in Scotland, said the treatment was "effective in preventing further disabling relapses and, in a proportion, appears to render [patients] effectively disabled free."

However, he added, the treatment also carried "substantial risks and safety concerns that underlines the need for future studies."

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Dr. Paolo Muraro, clinical reader in neuroimmunology at Imperial College London, added that while the treatment had some positive results, it may not be suitable in all cases of MS.

"It is not suitable for people with progressive forms of MS who have accumulated long-standing disability," he said. "For these people, the risks outweigh any potential benefit."