Crystal structure of JNK3 in complex with an imidazole-pyrimidine inhibitor

The structure was published by Scapin, G., Patel, S.B., Lisnock, J., Becker, J.W., and LoGrasso, P.V., in 2003 in a paper entitled "The structure of JNK3 in complex with small molecule inhibitors: structural basis for potency and selectivity" (abstract).

This crystal structure
was determined using
X-ray diffraction
at a resolution of 2.2 Å and deposited in 2003.

The PDB entry contains the structure of Mitogen-activated protein kinase 10.
This molecule has the UniProt identifier P53779 (MK10_HUMAN). The sample contained 364 residues which is < 90% of the natural sequence. Out of 364 residues 341 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):