Introduction
Insulin resistance of skeletalmuscle represents a major defect in the maintenance of euglycemia and is often accompanied by a variety of metabolic and cardiovascular abnormalities, including glucose intolerance, hyperinsulinemia

hyperglycemia rapidly developed skeletalmuscle insulin resistance while still in utero . The insulin signaling defects persisted through postnatal life, localized to skeletalmuscle. Uteroplacental insufficiency and fetal hyperinsulinism did not have these