Evidence-based practice (EBP) is an orientation to practice that values evidence as a resource for clinical decision making while recognizing that evidence alone is never sufficient to make a clinical decision. Critics of EBP typically ignore, negate, or misrepresent the role of practitioner thinking processes and expertise in clinical settings. The authors believe that, far from being a mechanistic process that ignores practitioner expertise, reflection and critical thinking are essential to implementing EBP in real-world clinical practice. The purpose of this article is to provide guidance for how practitioners bring their expertise to bear when engaging in the process of EBP. The authors use a social work practice scenario to illustrate the application of practitioner expertise in each of the five steps of EBP.