Ignition Coil Blown Out on 2001 Honda Civic

Check engine light came on a week ago and the codes were for multiple misfires. The first suspect was trash in gas because my wife had just gotten gas when it started. Today I'm driving to work and it begins missing and stuttering bad, it was a God awful noise. Open the hood and the ignition coil is broken and the part of it that goes down to spark plug(tube part) is literally hanging by two wires. It was like it was literally blown out. What could possibly cause this?

If you are talking about the actual spark plug wire that goes down the hole in the valve cover to the spark plug, it is most likely caused by a loose / stripped out spark plug itself. If the spark plug came loose, it will allow compression from the cylinder out and it will make the spark plug end pop off of the spark plug.