... A mild and efficient visible-light-induced atom transfer radical addition and cyclization of 1,n-enynes (n = 6, 7) with perfluoroalkyl halides, leading to halo-perfluorinated N-heterocycles, has been developed. This protocol offers a mild, completely atom-economic, and general access to perfluorinated 2,4-dihydronquinolin-2(1H)-ones and pyrrolidines from corresponding benzene and N-tethered 1,n-en ...

... A newly developed CF₃SO₂Na-based trifluoromethylation of secondary amines has been disclosed, and the method has been successfully extended to the configuration of perfluoroalkyl amines using RfSO₂Na, complementing the established synthesis strategy of trifluoromethyl amines. Advantages of the method include good functional group tolerance, mild conditions, and inexpensive or easy-to-handle materi ...

... The assembly of organized colonies is the earliest manifestation in the derivation or induction of pluripotency in vitro. However, the necessity and origin of this assemblance is unknown. Here, we identify human pluripotent founder cells (hPFCs) that initiate, as well as preserve and establish, pluripotent stem cell (PSC) cultures. PFCs are marked by N-cadherin expression (NCAD+) and reside exclus ...

... X-Shaped bolapolyphiles, comprising a linear polyaromatic core with glycerol groups at each end and two chemically different and incompatible chains, fixed to it at opposite sides, were synthesized and found to self-assemble into honeycomb-type liquid crystalline phases with square symmetry. The polyaromatic π-conjugated rods form the cell walls and the resulting prismatic cells of sub-5 nm size a ...

... The increasingly stringent restrictions on legacy per- and polyfluoroalkyl substances (PFASs) have led to the compensatory use of new fluorinated replacements. These new compounds, hereafter referred to as emerging PFASs, continue to be discovered and are now showing ubiquity in abiotic and biotic environments. Thus, there is an urgent need for robust, yet sensitive analytical methods to determine ...

... Catheter-based intra-arterial drug therapies have proven effective for a range of oncologic, neurologic, and cardiovascular applications. However, these procedures are limited by their invasiveness and relatively broad drug spatial distribution. The ideal technique for local pharmacotherapy would be noninvasive and would flexibly deliver a given drug to any region of the body with high spatial and ...

... A visible-light-promoted electron-donor–acceptor (EDA) complex-initiated [5 + 1] annulation between biguanides and perfluoroalkyl halides for the construction of perfluoroalkyl-s-triazines has been developed. It was found that both visible light and dioxygen in the air are favorable for the reaction. A radical–polar crossover mechanism was proposed, in which sequential SET, radical combination, HF ...

... Gas-phase techniques were used to examine the halogenation of deprotonated heterocycles by perfluoroaryl and perfluoroalkyl halides. The results indicate that SN2@Br and SN2@I reactions can be very facile and are effective means of halogenating heterocycles. 2-Iodoheptafluoropropane is exceptionally selective for SN2@I reactions with yields upward of 90%. The results also provide evidence counter ...

... Low-temperature processing in perovskite films always results in the formation of submicrometer scale grains and consequent abundant defects that lead to carrier recombination, hysteresis and moisture degradation. Passivation of defects at either surface or grain boundaries (GBs) thus promises great advances for developing high performance perovskite solar cells (PSCs). By taking the co-passivatio ...

... The aim of this study was to calibrate and apply polar organic chemical integrative samplers (POCIS) to examine 26 per- and polyfluoroalkyl substances (PFASs) in a drinking water treatment plant (DWTP). As a first step, the sampling rates (Rs) of 14 PFASs were determined in a laboratory calibration study for POCIS-WAX (weak-anion exchange) and POCIS-HLB (hydrophilic-lipophilic balance) (each with ...

... Perfluoroalkyl and polyfluoroalkyl substances (PFASs) represent a group of anthropogenic chemicals that were produced since the 1950s, however, voluntary and legal actions against the use of legacy PFASs were only implemented in recent years. These actions are aimed to trigger certain trends in PFAS chemistry, leading to the introduction of novel PFASs or the fortified use of short-chain derivativ ...

... This work aims to study changes in the electrochemical and transport properties of bilayered and multilayered ion-exchange membranes based on a Ralex AMH heterogeneous ion-exchange membrane. The composites studied are: a bilayer membrane consisting of a thin layer of perfluorocarbon cation-exchanger deposited on the surface of the Ralex membrane (Ralex/MF 4SK) as well as a composite with polyanili ...

... Bed sediments and a dated sediment core were collected upstream and downstream from the city of Lyon (France) to assess the spatial and temporal trends of contamination by per- and polyfluoroalkyl substances (PFASs) in this section of the Rhône River. Upstream from Lyon, concentrations of total PFASs (ΣPFASs) in sediments are low (between 0.19 and 2.6 ng g−1 dry weight - dw), being characterized b ...

... Several country–wide bans have recently been implemented for microbeads, which are a form of microplastics that are found in our oceans. The effect of the ban on reducing the overall quantity of microplastics in our oceans, however, may not be significant. This paper explores the scientific data related to microbeads to evaluate whether an underlying risk or combination of risks led to the ban, wh ...

... Contrast-enhanced ultrasound (CEUS) offers the exciting prospect of retaining the ease of ultrasound imaging while enhancing imaging clarity, diagnostic specificity, and theranostic capability. To advance the capabilities of CEUS, the synthesis and understanding of new ultrasound contrast agents (UCAs) is a necessity. Many UCAs are nano- or micro-scale materials composed of a perfluorocarbon (PFC) ...

... A site in northeastern Michigan, Oscoda Township, has some of the highest recorded exposure in birds to perfluorinated substances (PFASs) in the United States. Some egg and plasma concentrations at that location exceeded the lowest reproductive effect threshold established for two avian laboratory species. The objectives of this study were to determine whether there were reproductive effects or ph ...

... Solubility and diffusivity measurements of chlorodifluoromethane (HCFC-22) in four ionic liquids (ILs)—[emim][Tf₂N], [bmim][BF₄], [bmim][PF₆], and [emim][TFES]—were conducted using an IGA gravimetric microbalance at temperatures between 283.2 and 348.2 K. The solubility results were modeled using the NRTL activity coefficient method and were also used to calculate Henry’s law constants (kH) at inf ...