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According to estimates by the Maine Cancer Registry and the National Cancer Institute there are more than 700 new leukemia and lymphoma cases, and over 220 leukemia or lymphoma-related deaths, yearly in Maine. Chromosome abnormalities – such as broken chromosomes, rearrangements, and exchanges of material between different chromosomes – are hallmarks of leukemia and lymphoma. This project aims to identify and investigate the cellular processes that normally protect against cancer-related chromosome rearrangements. This work will be essential to 1) understanding the origins of chromosome abnormalities and how they may lead to cancer; and 2) developing better diagnosis and/or treatment strategies.