The LowCell# ChIP kit protein A is one of Diagenode old generation ChIP kits, still present in the catalogue. At present we highly recommend our new generation True MicroChIP kit with optimized reagents and protocol to enable successful ChIP/ChIP-seq on as few as 10 000 cells. Read more about our True MicroChIP kit.

The LowCell# ChIP kit has been validated using chromatin sheared by sonication using the Bioruptor®. The Kit includes a DNA purifying slurry for a fast method to purify your IP’d material (for qPCR analysis).

A LINE1-Nucleolin Partnership Regulates Early Development and ESC Identity.Percharde M, Lin CJ, Yin Y, Guan J, Peixoto GA, Bulut-Karslioglu A, Biechele S, Huang B, Shen X, Ramalho-Santos MTransposable elements represent nearly half of mammalian genomes and are generally described as parasites, or "junk DNA." The LINE1 retrotransposon is the most abundant class and is thought to be deleterious for cells, yet it is paradoxically highly expressed during early development. Here, we report that LINE1 play...

Epigenome profiling and editing of neocortical progenitor cells during developmentAlbert M. et al.The generation of neocortical neurons from neural progenitor cells (NPCs) is primarily controlled by transcription factors binding to DNA in the context of chromatin. To understand the complex layer of regulation that orchestrates different NPC types from the same DNA sequence, epigenome maps with cell type resoluti...

Genomic Characterization of Metformin Hepatic ResponseLuizon M.R. et al.Metformin is used as a first-line therapy for type 2 diabetes (T2D) and prescribed for numerous other diseases. However, its mechanism of action in the liver has yet to be characterized in a systematic manner. To comprehensively identify genes and regulatory elements associated with metformin treatment, we carried o...

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