1993: Apple introduces the Newton handheld computer. The company reports quarterly loss of $188 million in July, and Sculley is replaced by Apple President Michael Spindler. Apple restructures and Sculley resigns as chairman. At NeXT, Jobs decides to focus on software.

1994: Apple introduces Power Macintosh computers based on the PowerPC chip it developed with IBM and Motorola. Apple decides to license its operating software, allowing other companies to clone the Mac.

1995: The first Mac clones go on sale. Microsoft releases Windows 95, which is easier to use and more like the Macintosh. Apple struggles with competition, parts shortages and mistakes predicting customer demand. "Toy Story," the first commercial computer-animated feature, hits theaters and Pixar goes to Wall Street with an IPO that raises $140 million.

2008: Speculation mounts that Jobs is ill, given his weight loss. In September he kicks off an Apple event and says, "The reports of my death are greatly exaggerated."

2009: On Jan. 5, Jobs explains weight loss by saying he has a treatable hormone imbalance and that he will continue to run Apple. Days later he backtracks and announces he will be on medical leave. He returns to work in June. Later it is learned that he received a liver transplant.

2010: Apple sells 15 million iPads in nine months, giving rise to a new category of touch-screen tablet computers.

Jan. 17: In an Apple memo, Jobs announces a second medical leave. Chief Operating Officer Tim Cook fills in to run day-to-day operations. Jobs says he will be involved in major decisions.

Aug. 24: Apple announces Jobs is resigning as CEO. The company says he will be replaced by Cook and that Jobs will stay on as chairman.