The above ligands show the molecular electrostatic
potentials (MEPs)(negative regions are colored red and positive regions are
colored blue) of the ligands 5-HT (serotonin), BUFO (bufotenin) and TRYP
(tryptamine) molecules not docked into the 5HT2A receptor. The molecules below
are the MEPs of these ligands docked with the 5HT2A receptor in the acid (SH)
state (see this link for the receptor
model and this link for the paper):

5-HTBUFOTRYP

The same ligands as above, but docked with the 5HT2A
receptor in the base (S-) state: