IACC Autism Spectrum Disorder Research Portfolio Analysis: Project Listing
Project Id Project Number Sub Project Number Funder Principal Investigator Project Title Project Description Fiscal Year Funding Category Subcategory Strategic Plan Objective Objective Status Code Arra Funded? Federal/Private Institution State/Country Project Status Web Link 1 Web Link 2 Web Link 3 Active Current Award Period
Project Id: 3707 6251 None Autism Speaks Sourander, Andre Multi-registry analyses for iCARE - Finland This proposal builds on the Autism Speaks-Centers for Disease Control and Prevention (CDC) International Autism Epidemiology Network Registry Workgroup. The Workgroup established the International Collaboration for Autism Registry Epidemiology (iCARE) and identified relevant registry systems for the proposed investigation in Scandinavia (Denmark, Sweden, Finland and Norway), Australia and Israel. The goals of the investigation are 1) to establish the necessary infrastructure for multi-registry autism research, including establishing a multi-registry virtual data set approach to analysis and establishing written guidelines for multi-national registry-based research collaboration, and 2) demonstrate the capabilities of the multi-registry approach to elucidate etiological pathways to autism by thoroughly investigating candidate factors for perinatal adversity in relation to autism, beginning with gestational length and fetal growth. The study will consider variation in diagnostic criteria and trends over time, and based on heretofore unrivaled sample sizes that will permit examination of risk across more finely defined birth weight and gestational age categories; consider effects on risk of fetal size at a given gestational age; control for confounding; and conduct robust stratified analyses considering other important risk factors, such as gender, parental age, and birth multiplicity, and features of autism, such as diagnostic subtype. The proposed project presets a new scope in epidemiological investigation into risk factors for autism, and will provide the foundation and guidelines for future investigations. $41,910.00 Causes Environment Question 3: Short-term Objective H Yellow dot: Objective has some degree of funding, but less than the recommended amount. No Private Turku University Finland Ongoing http://www.autismspeaks.org/science/grants/multi-registry-analyses-finland?destination=science%2Fgrant-search%2Fresults%2FMulti-registry+analyses+for+iCARE No URL available. No URL available. active 2009-2012
Project Id: 3702 6246 None Autism Speaks Gross, Raz Multi-registry analyses for iCARE - Israel This proposal builds on the Autism Speaks-Centers for Disease Control and Prevention (CDC) International Autism Epidemiology Network Registry Workgroup. The Workgroup established the International Collaboration for Autism Registry Epidemiology (iCARE) and identified relevant registry systems for the proposed investigation in Scandinavia (Denmark, Sweden, Finland and Norway), Australia and Israel. The goals of the investigation are 1) to establish the necessary infrastructure for multi-registry autism research, including establishing a multi-registry virtual data set approach to analysis and establishing written guidelines for multi-national registry-based research collaboration, and 2) demonstrate the capabilities of the multi-registry approach to elucidate etiological pathways to autism by thoroughly investigating candidate factors for perinatal adversity in relation to autism, beginning with gestational length and fetal growth. The study will consider variation in diagnostic criteria and trends over time, and based on heretofore unrivaled sample sizes that will permit examination of risk across more finely defined birth weight and gestational age categories; consider effects on risk of fetal size at a given gestational age; control for confounding; and conduct robust stratified analyses considering other important risk factors, such as gender, parental age, and birth multiplicity, and features of autism, such as diagnostic subtype. The proposed project presets a new scope in epidemiological investigation into risk factors for autism, and will provide the foundation and guidelines for future investigations. $41,943.00 Causes Environment Question 3: Short-term Objective H Yellow dot: Objective has some degree of funding, but less than the recommended amount. No Private The Gertner Institute of Epidemiology and Health Policy Research Israel Ongoing http://www.autismspeaks.org/science/grants/multi-registry-analyses-israel?destination=science%2Fgrant-search%2Fresults%2FMulti-registry+analyses No URL available. No URL available. active 2009-2012
Project Id: 3710 5K08MH079176-04 None National Institutes of Health Behen, Michael Structural and functional neural correlates of early postnatal deprivation This is a Clinical Investigator Award, providing an opportunity for a medical investigator to develop into an independent researcher. Despite links between early postnatal deprivation (ESD) and neuropsychological problems, few studies have investigated whether the neural substrates thought to underlie such functions are abnormal in children with such histories. The overarching aim of the proposed studies is to probe, with imaging techniques, the structural and functional neurobiological consequences of ESD. The approach of integrating magnetic resonance imaging (MRI) and positron emission tomography (PET) methods with neuropsychological assessments is innovative and will yield new and important data on children exposed to ESD. These studies have potential translational value, as neuroimaging data can be used to monitor effects of therapeutic interventions and to assess the potential reversibility of findings, which has not been possible in the past. $150,412.00 Causes Environment Question 3: Short-term Objective H Yellow dot: Objective has some degree of funding, but less than the recommended amount. No Federal Wayne State University Michigan Ongoing http://projectreporter.nih.gov/project_info_description.cfm?aid=7891165&icde=8964882 No URL available. No URL available. active 2007-2012
Project Id: 3708 6247 None Autism Speaks Stoltenberg, Camilla Multi-registry analyses for iCARE - Norway This proposal builds on the Autism Speaks-Centers for Disease Control and Prevention (CDC) International Autism Epidemiology Network Registry Workgroup. The Workgroup established the International Collaboration for Autism Registry Epidemiology (iCARE) and identified relevant registry systems for the proposed investigation in Scandinavia (Denmark, Sweden, Finland and Norway), Australia and Israel. The goals of the investigation are 1) to establish the necessary infrastructure for multi-registry autism research, including establishing a multi-registry virtual data set approach to analysis and establishing written guidelines for multi-national registry-based research collaboration, and 2) demonstrate the capabilities of the multi-registry approach to elucidate etiological pathways to autism by thoroughly investigating candidate factors for perinatal adversity in relation to autism, beginning with gestational length and fetal growth. The study will consider variation in diagnostic criteria and trends over time, and based on heretofore unrivaled sample sizes that will permit examination of risk across more finely defined birth weight and gestational age categories; consider effects on risk of fetal size at a given gestational age; control for confounding; and conduct robust stratified analyses considering other important risk factors, such as gender, parental age, and birth multiplicity, and features of autism, such as diagnostic subtype. The proposed project presets a new scope in epidemiological investigation into risk factors for autism, and will provide the foundation and guidelines for future investigations. $39,426.00 Causes Environment Question 3: Short-term Objective H Yellow dot: Objective has some degree of funding, but less than the recommended amount. No Private Norwegian Institute of Public Health Norway Ongoing http://www.autismspeaks.org/science/grants/multi-registry-analyses-norway?destination=science%2Fgrant-search%2Fresults%2FMulti-registry+analyses+for+iCARE No URL available. No URL available. active 2009-2012
Project Id: 3706 3681 None Autism Speaks Reichenberg, Avi Assisted reproductive treatments and risk of autism In the past decade, the use of assisted reproductive treatments such as in vitro fertilization and intracytoplasmatic sperm injection has consistently increased, with approximately 1% of infants born in 2004 being conceived through such treatments. As well, there is accumulating evidence suggesting that there may be a relationship between the use of assisted reproductive treatments and autism spectrum disorders (ASD) in children born as the result of such treatments. In the present study, researchers will use population-based health records collected in Sweden for all infants born between 1982 and 2001, including those born after assisted reproduction treatments. Dr. Reichenberg and colleagues will analyze the data to determine whether diagnoses of ASD link to the use of assisted reproductive treatments as well as to other potentially relevant factors such as parental age and perinatal indices such as birth weight. $59,686.00 Causes Environment Question 3: Short-term Objective H Yellow dot: Objective has some degree of funding, but less than the recommended amount. No Private Institute of Psychiatry, King's College London United Kingdom Ongoing http://www.autismspeaks.org/science/grants/assisted-reproductive-treatments-and-risk-autism?destination=science%2Fgrant-search%2Fresults%2Freichenberg No URL available. No URL available. active 2009-2010
Project Id: 3701 2499 None Autism Speaks Ebstein, Richard Effect of oxytocin receptor inhibitor (atosiban) during the perinatal period and prevalence of autism spectrum disorders Among environmental factors that may confer risk for autism, perinatal factors are prominent. Based on multiple lines of research, it has been hypothesized that activity of the hormone oxytocin – a 'social' hormone that mediates affiliative behaviors in many species including humans – may be a perinatal factor that impacts the risk of autism spectrum disorders (ASD). This study will take an epidemiological approach to determining the roles of Pitocin and Atosiban in ASD. Dr. Ebstein and colleagues will recruit mother and child pairs from four categories: mothers having received Atosiban during pregnancy; mothers having received Nifedipine, a drug used to prevent preterm labor that does not affect oxytocin signaling; mothers that received Pitocin during labor; and a matched control group of mothers who received no drugs and delivered at term. Children of these mothers will be screened for neurodevelopmental delays, and those testing positive will undergo further evaluations for ASD. $122,950.00 Causes Environment Question 3: Short-term Objective H Yellow dot: Objective has some degree of funding, but less than the recommended amount. No Private Hebrew University Israel Ongoing http://www.autismspeaks.org/science/grants/effect-oxytocin-receptor-inhibitor-atosiban-during-perinatal-period-and-prevalence-au?destination=science%2Fgrant-search%2Fresults%2Febstein No URL available. No URL available. active 2009-2011
Project Id: 3700 6248 None Autism Speaks Bresnahan, Michaeline Multi-registry analyses for iCARE - Data Management Core This proposal builds on the Autism Speaks-Centers for Disease Control and Prevention (CDC) International Autism Epidemiology Network Registry Workgroup. The Workgroup established the International Collaboration for Autism Registry Epidemiology (iCARE) and identified relevant registry systems for the proposed investigation in Scandinavia (Denmark, Sweden, Finland and Norway), Australia and Israel. The goals of the investigation are 1) to establish the necessary infrastructure for multi-registry autism research, including establishing a multi-registry virtual data set approach to analysis and establishing written guidelines for multi-national registry-based research collaboration, and 2) demonstrate the capabilities of the multi-registry approach to elucidate etiological pathways to autism by thoroughly investigating candidate factors for perinatal adversity in relation to autism, beginning with gestational length and fetal growth. The study will consider variation in diagnostic criteria and trends over time, and based on heretofore unrivaled sample sizes that will permit examination of risk across more finely defined birth weight and gestational age categories; consider effects on risk of fetal size at a given gestational age; control for confounding; and conduct robust stratified analyses considering other important risk factors, such as gender, parental age, and birth multiplicity, and features of autism, such as diagnostic subtype. The proposed project presets a new scope in epidemiological investigation into risk factors for autism, and will provide the foundation and guidelines for future investigations. $76,219.00 Causes Environment Question 3: Short-term Objective H Yellow dot: Objective has some degree of funding, but less than the recommended amount. No Private Columbia University New York Ongoing http://www.autismspeaks.org/science/grants/multi-registry-analyses-data-mgt-core?destination=science%2Fgrant-search%2Fresults%2FMulti-registry+analyses+for+iCARE No URL available. No URL available. active 2009-2012
Project Id: 3705 6295 None Autism Speaks Parner, Eric Multi-registry analyses for iCARE - Denmark This proposal builds on the Autism Speaks-Centers for Disease Control and Prevention (CDC) International Autism Epidemiology Network Registry Workgroup. The Workgroup established the International Collaboration for Autism Registry Epidemiology (iCARE) and identified relevant registry systems for the proposed investigation in Scandinavia (Denmark, Sweden, Finland and Norway), Australia and Israel. The goals of the investigation are 1) to establish the necessary infrastructure for multi-registry autism research, including establishing a multi-registry virtual data set approach to analysis and establishing written guidelines for multi-national registry-based research collaboration, and 2) demonstrate the capabilities of the multi-registry approach to elucidate etiological pathways to autism by thoroughly investigating candidate factors for perinatal adversity in relation to autism, beginning with gestational length and fetal growth. The study will consider variation in diagnostic criteria and trends over time, and based on heretofore unrivaled sample sizes that will permit examination of risk across more finely defined birth weight and gestational age categories; consider effects on risk of fetal size at a given gestational age; control for confounding; and conduct robust stratified analyses considering other important risk factors, such as gender, parental age, and birth multiplicity, and features of autism, such as diagnostic subtype. The proposed project presets a new scope in epidemiological investigation into risk factors for autism, and will provide the foundation and guidelines for future investigations. $29,162.00 Causes Environment Question 3: Short-term Objective H Yellow dot: Objective has some degree of funding, but less than the recommended amount. No Private Aarhus University Georgia Ongoing http://www.autismspeaks.org/science/grants/multi-registry-analyses-denmark?destination=science%2Fgrant-search%2Fresults%2FMulti-registry+analyses+for+iCARE No URL available. No URL available. active 2009-2012
Project Id: 3704 6249 None Autism Speaks Leonard, Helen Multi-registry analyses for iCARE- West Australia This proposal builds on the Autism Speaks-Centers for Disease Control and Prevention (CDC) International Autism Epidemiology Network Registry Workgroup. The Workgroup established the International Collaboration for Autism Registry Epidemiology (iCARE) and identified relevant registry systems for the proposed investigation in Scandinavia (Denmark, Sweden, Finland and Norway), Australia and Israel. The goals of the investigation are 1) to establish the necessary infrastructure for multi-registry autism research, including establishing a multi-registry virtual data set approach to analysis and establishing written guidelines for multi-national registry-based research collaboration, and 2) demonstrate the capabilities of the multi-registry approach to elucidate etiological pathways to autism by thoroughly investigating candidate factors for perinatal adversity in relation to autism, beginning with gestational length and fetal growth. The study will consider variation in diagnostic criteria and trends over time, and based on heretofore unrivaled sample sizes that will permit examination of risk across more finely defined birth weight and gestational age categories; consider effects on risk of fetal size at a given gestational age; control for confounding; and conduct robust stratified analyses considering other important risk factors, such as gender, parental age, and birth multiplicity, and features of autism, such as diagnostic subtype. The proposed project presets a new scope in epidemiological investigation into risk factors for autism, and will provide the foundation and guidelines for future investigations. $84,445.00 Causes Environment Question 3: Short-term Objective H Yellow dot: Objective has some degree of funding, but less than the recommended amount. No Private The University of Western Australia Australia Ongoing http://www.autismspeaks.org/science/grants/multi-registry-analyses-western-australia?destination=science%2Fgrant-search%2Fresults%2FMulti-registry+analyses+for+iCARE No URL available. No URL available. active 2009-2012
Project Id: 3709 5U10DD000230-05 None Centers for Disease Control and Prevention Olsen, Jorn Epidemiologic studies of reproductive and developmental outcomes – Denmark The CDC-Denmark program is funded to develop and implement a United States-Denmark collaborative laboratory and epidemiologic infrastructure to examine a variety of public health issues. It augments the Centers for Disease Control and Prevention's capabilities to achieve its strategic objectives by using Denmark's unique data infrastructure to address questions for which data are not currently available in the U.S., or would be much more costly to replicate. Note: The total funding for this grant is $1,100,000, of which $400,000 is distributed to research involving autism. Thus, this latter amount was included in the 2009 Portfolio Analysis. $300,615.00 Causes Environment Question 3: Short-term Objective H Yellow dot: Objective has some degree of funding, but less than the recommended amount. No Federal Aarhus University Denmark Ongoing http://www.cdc.gov/ncbddd/autism/documents/DenmarkCADDRE.pdf http://projectreporter.nih.gov/project_info_description.cfm?aid=7763780&icde=7413352 No URL available. active 2007-2012
Project Id: 3712 5R21HD057808-02 None National Institutes of Health Rahbar, Mohammad Epidemiological research on autism in Jamaica The prevalence of autism spectrum disorders (ASD) appears to be on the rise in developed countries and has become a serious public health concern. In most developing countries, however, the nature and prevalence of factors associated with ASDs are unknown. The long term goal of this planning project is to develop capacity for conducting large scale population-based ASD studies in Jamaica. First, the diagnostic criteria used in Jamaica and the United States will be compared. Then, questionnaires regarding the demographic and socioeconomic position, occupation, and drinking habits of each child's parents will be used, and information will be gathered about family history of developmental disorders, family size, birth order of the affected child, and whether the child is taking any medications. An age and sex matched case-control study, including a dietary questionnaire, will also be conducted to investigate whether environmental exposures to mercury, lead, arsenic, and cadmium play a role in autism. Blood and saliva samples will be collected to determine if any DNA polymorphisms that might affect interactions with heavy metals are present in children with ASD. New knowledge of potential environmental risk factors for ASD may arise from this research, thereby reducing physical, psychological, and economic burdens on the child, family, and society and helping parents make decisions about avoiding exposure to environmental contaminants. $131,010.00 Causes Environment Question 3: Short-term Objective H Yellow dot: Objective has some degree of funding, but less than the recommended amount. No Federal University of Texas Health Science Center at Houston Texas Ongoing http://projectreporter.nih.gov/project_info_description.cfm?aid=7858211&icde=8942647 No URL available. No URL available. active 2009-2012
Project Id: 3711 5R01ES019004-02 None National Institutes of Health Brown, Alan Prenatal factors and risk of autism in a Finnish national birth cohort This research will investigate whether environmental factors during pregnancy are related to the likelihood that offspring will be diagnosed with autism. Environmental factors such as infections, immune abnormalities, hormones, and smoking will be assessed in pregnancies of 1,000 autism cases and 1,000 healthy children using maternal serum samples that were drawn and stored in nearly all pregnancies in Finland from 1987-2007. Children with autism and healthy children matched to the cases on sex, date of birth, birth place and residence in Finland will be identified from detailed national databases that contain diagnoses on nearly all cases of autism in Finland. Researchers will also test whether there are differences in susceptibility to these environmental factors between boys and girls with autism. This research has the potential to result in a better understanding of the different causes of autism and different developmental pathways that can lead to the illness. The discovery of these causes can lead to prevention of cases of autism by improved prenatal care and to the identification of children who are at risk of developing autism. $408,838.00 Causes Environment Question 3: Short-term Objective H Yellow dot: Objective has some degree of funding, but less than the recommended amount. Yes Federal New York State Psychiatric Institute New York Ongoing http://projectreporter.nih.gov/project_info_description.cfm?aid=7941826&icde=6668679 No URL available. No URL available. active 2009-2011
Project Id: 3703 6230 None Autism Speaks Hultman, Christina Multi-registry analyses for iCARE- Sweden This proposal builds on the Autism Speaks-Centers for Disease Control and Prevention (CDC) International Autism Epidemiology Network Registry Workgroup. The Workgroup established the International Collaboration for Autism Registry Epidemiology (iCARE) and identified relevant registry systems for the proposed investigation in Scandinavia (Denmark, Sweden, Finland and Norway), Australia and Israel. The goals of the investigation are 1) to establish the necessary infrastructure for multi-registry autism research, including establishing a multi-registry virtual data set approach to analysis and establishing written guidelines for multi-national registry-based research collaboration, and 2) demonstrate the capabilities of the multi-registry approach to elucidate etiological pathways to autism by thoroughly investigating candidate factors for perinatal adversity in relation to autism, beginning with gestational length and fetal growth. The study will consider variation in diagnostic criteria and trends over time, and based on heretofore unrivaled sample sizes that will permit examination of risk across more finely defined birth weight and gestational age categories; consider effects on risk of fetal size at a given gestational age; control for confounding; and conduct robust stratified analyses considering other important risk factors, such as gender, parental age, and birth multiplicity, and features of autism, such as diagnostic subtype. The proposed project presets a new scope in epidemiological investigation into risk factors for autism, and will provide the foundation and guidelines for future investigations. $41,250.00 Causes Environment Question 3: Short-term Objective H Yellow dot: Objective has some degree of funding, but less than the recommended amount. No Private Karolinska Institutet Sweden Ongoing http://www.autismspeaks.org/science/grants/multi-registry-analyses-sweden?destination=science%2Fgrant-search%2Fresults%2FMulti-registry+analyses+for+iCARE No URL available. No URL available. active 2009-2012
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