Rates of women who are opting for preventive mastectomies, such as Angeline Jolie, have increased by an estimated 50 percent in recent years, experts say. But many doctors are puzzled because the operation doesn't carry a 100 percent guarantee, it's major surgery -- and women have other options, from a once-a-day pill to careful monitoring.

Women who ate more than 1½ servings of red meat per day were almost twice as likely to develop hormone-related breast cancer as those who ate fewer than three portions per week, one study found.

The other — one of the longest and largest tests of whether supplements of various vitamins can prevent heart problems and strokes in high-risk women — found that the popular pills do no good, although there were hints that women with the highest risk might get some benefit from vitamin C.

The meat study was published in Monday’s Archives of Internal Medicine. The vitamin study was presented at an American Heart Association conference in Chicago. Both were led by doctors at Harvard Medical School and were aimed at two diseases women most fear and want to prevent.

Antioxidants like vitamins C and E attach to substances that can damage cells. Scientists have been testing them for preventing such diseases as Alzheimer’s and cancer.

This is the first large study to test vitamin C alone, not in combination with E or other vitamins, for heart health, said Dr. JoAnn Manson, chief of preventive medicine at Harvard-affiliated Brigham and Women’s Hospital in Boston, who led the research.

More than 8,000 women were randomly assigned to take vitamin C, E or beta carotene alone or in various combinations for nearly a decade. An additional 5,442 women took folic acid and B vitamin supplements for more than seven years.

“Overall, there was minimal evidence of any cardiovascular benefit of any of these antioxidants,” and people should not start or continue taking them for that purpose, Manson said.

Among the 3,000 women in the study who had no prior heart disease but three or more risk factors for it, those who received vitamin C alone or in combination had a 42 percent lower risk of stroke. Smokers taking C also had a 48 percent lower risk.

Vitamin E could help a little
Vitamin E may give very small benefits for some women, the study suggests. Those with prior heart disease had a 12 percent reduction in the risk of new heart problems, Manson said.

“Many of these subgroup findings are intriguing. However, they need to be confirmed in other studies,” Manson said. “We don’t want this to be interpreted as a conclusive finding.”

What does appear conclusive is that folic acid and B vitamins “are not effective as preventive agents,” said Dr. Christine Albert, who presented that portion of the study at the heart meeting on Monday. These nutrients lower homocysteine, a blood substance thought to increase heart disease risk, but many studies now call the importance of that into question.

The meat study was based on observation rather than an experiment. The Nurses’ Health Study tracked the diets and health of more than 90,000 women who were 26 to 46 years old when they enrolled roughly two decades ago.

They filled out diet questionnaires in 1991, 1995 and 1999, and were divided into five groups based on how much red meat they said they ate. Researchers checked on their health for 12 years on average and confirmed breast cancer diagnoses with medical records.

Meat consumption was linked to a risk of developing tumors whose growth was fueled by estrogen or progesterone — the most common type — but not to tumors that grow independently of these hormones.

The women who ate more red meat were more likely to smoke and be overweight, but when the researchers took those factors into account, they still saw that red meat was linked with an increased risk of breast cancer.

Red meat also raises risk of colorectal cancer
Earlier studies have found that obesity raises the risk of breast cancer and that red meat raises the risk of colorectal cancer.

However, Dr. Anne McTiernan of the Fred Hutchinson Cancer Research Center in Seattle cautioned that the findings rely on women’s recall of what they ate — an inexact way to measure diet.

“A 16-ounce steak and a three-ounce piece of meat are counted the same. People are horrible at determining what is a real serving,” said McTiernan, author of “Breast Fitness,” a book on reducing cancer risk.

It may be wise to cut down on red meat because of its fat and calorie content, McTiernan said, but “this isn’t a reason to become a vegetarian if you weren’t planning to do that already.”