Datasheet Extract

A synthetic peptide from the n-terminal part of human Beclin-1-like protein 1 conjugated to an immunogenic carrier protein has been used as the immunogen.

Add. information

Reconstitute in 0.1 ml of sterile water. Centrifuge to remove any insoluble material. When reconstituting, glycerol (1:1) may be added for an additional stability.

Application

immunohistochemistry, Western Blot, This antibody is useful for Immunohistochemistry and Western Blot., immunohistochemistry, Western Blot 1:400-1:5000,

Background

Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. It may play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus. May play a role in autophagy.; FUNCTION: May play a role in autophagy and antiviral host defense.; SUBCELLULAR LOCATION: Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein.

Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.