Application Information: DC-SIGN antibody [MR-1] (FITC)

Flow cytometry/FACS : Use 10μl of the suggested working dilution to label 106 cells in 100μl.

Not tested in other applications. *Optimal dilutions/concentrations should be determined by the researcher.

Form Supplied

Liquid

Concentration

0.1
mg/ml
(Please refer to the vial label for the specific concentration)

Purification

Protein A purified

Purification Note

From tissue culture supernatant

Specifications: DC-SIGN antibody [MR-1] (FITC)

Full Name

CD209 molecule

Background

This gene encodes a transmembrane receptor and is often referred to as DC-SIGN because of its expression on the surface of dendritic cells and macrophages. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are rare but have a significant i