Chart

In the following sample, all the weekends (Saturday and Sunday) of a month are
disabled, and these dates are restricted to set or select in the DateTimePicker.

DEMO

SOURCE

Disabled Dates sample demonstrates how to disable specific dates in the Calendar by using renderDayCell event. This event gets triggered on each day cell element creation, that allows you to customize, or disable specific
dates in the Calendar. Here the weekend dates are disabled by using renderDayCell.