Anissa Abi-DarghamDepartment of Psychiatry, Columbia University, and New York State Psychiatric Institute, New York, 10032, USABiol Psychiatry 55:1001-6. 2004

..Schizotypal personality disorder (SPD) is a schizophrenia spectrum disorder, genetically related to schizophrenia. The goal of this study was to investigate striatal DA function in patients with SPD...

Quantitative analysis of (-)-N-(11)C-propyl-norapomorphine in vivo binding in nonhuman primates

Dah Ren HwangDepartment of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USAJ Nucl Med 45:338-46. 2004

..The goal of this study was to develop and evaluate analytic strategies to derive in vivo (11)C-NPA binding parameters...

Measurement of the serotonin 1A receptor availability in patients with schizophrenia during treatment with the antipsychotic medication ziprasidone

W Gordon FrankleDepartment of Psychiatry, Columbia University College of Physicians and Surgeons, New York, USAJ Psychopharmacol 25:734-43. 2011

..The finding of a relationship between 5-HT(1A) binding and the degree of improvement in negative symptoms provides further support for the role of the 5-HT(1A) receptor in the pathophysiology and treatment of this symptom domain...

Positron emission tomography of regional brain metabolic responses to a serotonergic challenge and lethality of suicide attempts in major depression

..Alterations in mood, cognition, and impulse control associated with these changes might contribute to sustain MDMA use. The reversibility of these changes upon abstinence remains to be firmly established...

Nina B L UrbanDepartment of Psychiatry at New York State Psychiatric Institute and Columbia University, New York, New York 10032, USABiol Psychiatry 68:689-96. 2010

..We used a positron emission tomography paradigm with the D2/3 radiotracer [¹¹C]raclopride and an alcohol challenge to examine the magnitude of alcohol-induced dopamine release and compare it between young men and women...

..These results suggest caution in interpreting data from studies using this tracer to measure cortical D(1) receptors as well as the need for more selective radioligands to assess cortical D(1) receptors...

Dopamine mediation of positive reinforcing effects of amphetamine in stimulant naïve healthy volunteers: results from a large cohort

Sanjay J MathewDepartment of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York, USABiol Psychiatry 54:727-35. 2003

..Long-term behavioral, immunologic, and neurochemical alterations have been found in primates exposed to adverse early rearing...

Glutamate, dopamine, and schizophrenia: from pathophysiology to treatment

Marc LaruelleDepartment of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York 10032, USAAnn N Y Acad Sci 1003:138-58. 2003

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Effects of davunetide on N-acetylaspartate and choline in dorsolateral prefrontal cortex in patients with schizophrenia

L Fredrik JarskogDepartment of Psychiatry, University of North Carolina Chapel Hill School of Medicine, Chapel Hill, NC, USANeuropsychopharmacology 38:1245-52. 2013

..Future clinical and preclinical studies are needed to fully define the mechanism of action and cognitive effects of davunetide in schizophrenia...

Prefrontal dopamine D1 receptors and working memory in schizotypal personality disorder: a PET study with [¹¹C]NNC112

Judy L ThompsonDepartment of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, 10032, USAPsychopharmacology (Berl) 231:4231-40. 2014

..Imaging studies have suggested that schizophrenia is associated with alterations in dopamine D1 receptor availability in the prefrontal cortex (PFC) that may be related to the WM impairments that characterize this disorder...

Helen Blair SimpsonDepartment of Psychiatry at Columbia University Medical Center, College of Physicians and Surgeons, Columbia University, New York, NY, United States Division of Clinical Therapeutics at the New York State Psychiatric Institute, New York, NY, United States Electronic addressPsychiatry Res 232:65-70. 2015

..Further studies are warranted to assess whether these discrepant MRS findings are due to differences in subject age or MRS methodology, or potentially are associated with glutamatergic gene variants implicated in OCD. ..

Synthesis and pharmacological characterization of a new PET ligand for the serotonin transporter: [11C]5-bromo-2-[2-(dimethylaminomethylphenylsulfanyl)]phenylamine ([11C]DAPA)

Yiyun HuangDepartment of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY 10032, USANucl Med Biol 29:741-51. 2002

..In summary, [11C]DAPA appears to be a promising radioligand suitable for the visualization of SERT in vivo using PET...

Synthesis and in vivo evaluation of [11C]zolpidem, an imidazopyridine with agonist properties at central benzodiazepine receptors

..A PET brain imaging study in one baboon confirmed the results obtained in rats. Therefore, it can be concluded that [(11)C]zolpidem is not a suitable tracer for in vivo visualization of central benzodiazepine receptors...

Carolyn I Rodriguez1 New York State Psychiatric Institute, New York, NY, USA 2 Department of Psychiatry, Columbia University, College of Physicians and Surgeons, New York, NY, USANeuropsychopharmacology 38:2475-83. 2013

..This is the first randomized, controlled trial to demonstrate that a drug affecting glutamate neurotransmission can reduce OCD symptoms without the presence of an SRI and is consistent with a glutamatergic hypothesis of OCD...

Diana MartinezDepartment of Psychiatry, Columbia University College of Physicians and Surgeons and the New York State Psychiatric Institute, New York, New York Electronic addressBiol Psychiatry 75:165-71. 2014

..The goal of this study was to use imaging of the human brain to investigate alterations in the glutamate signaling in cocaine addiction...

Yolanda Zea-PonceDepartments of Psychiatry and Radiology, Columbia University College of Physicians and Surgeons, New York, New York, USANucl Med Biol 29:575-83. 2002

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Glutamatergic abnormalities in schizophrenia: a review of proton MRS findings

Eline M P PoelsDepartment of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA New York State Psychiatric Institute, New York, NY, USASchizophr Res 152:325-32. 2014

..We will review the contribution of (1)H-MRS studies to our knowledge about glutamatergic abnormalities in the brains of individuals with SCZ and discuss the implications for future research and clinical care. ..