Membrane type (MT) matrix metalloproteinases (MMPs) are recently recognized members of the family of Zn(2+)- and Ca(2+)-dependent MMPs. MMP-17 is, therefore, a competent Zn(2+)-dependent MMP with unique specificity among synthetic substrates and the capability to both degrade gelatin and activate progelatinase A (1). (MMP-17) is expressed mainly in the brain, leukocytes, the colon, the ovary, and the testis. The expression of MMP-17 in leukocytes together with its putative membrane localization suggest that this enzyme could be involved in the activation of membrane-bound precursors of growth factors or inflammatory mediators such as tumor necrosis factor-alpha (2). glycosylphospha-tidylinositol (GPI) anchoring of MT4-MMP on the cell surface indicates a unique biological function and character for this proteinase (3).

General Readings

Puente XS, et al. Cancer Res. 56(5):944-9, 1996.

Wang Y, et al. J Biol Chem. 274(46):33043-9, 1999.

Itoh Y, et al. J Biol Chem 274(48):34260-6, 1999.

Storage

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Format

Buffer System:

0.01% Sodium Azide

State:

Aff - Purified

Specificity

Specificity:

A synthetic peptide corresponding to residues on human MMP-17 was used as an immunogen.