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Abstract

Three dimensional rapid large depth range imaging of the anterior segments of the human eye by an optical frequency domain imaging system is presented. The tunable source spans from 1217 to 1356 nm with an average output power of 60 mW providing a measured axial resolution of 10 μm in air based on the coherence envelope. The effective depth range is 4 mm, defined as the distance over which the sensitivity drops by 6 dB, achieved by frequency shifting the optical signal using acousto-optic modulators. The measured maximum sensitivity is 109 dB at a sample arm power of 14.7mW and A-lines rate of 43,900 per second. Images consisting of 512 depth profiles are acquired at an acquisition rate of 85 frames per second. We demonstrate an optical frequency domain imaging system capable of mapping in vivo the entire area of the human anterior segment (13.4 × 12 × 4.2 mm) in 1.4 seconds.

Axial point spread function of a partial reflector placed in the sample arm at different depth locations. An intensity drop of 6dB at ~2mm (dashed line) is measured on each side of the coherence function (in air).

(3.58 MB) Sequence of 120 images of the cornea anterior segments of the right eye of a healthy volunteer. Each image frame consists of 490 depth profiles and spans a horizontal range of 13.4mm along horizontal (x-axis) and 4.15mm in depth along a vertical scan of 12mm. Total of 120 frames were acquired in 1.4 seconds. [Media 1]

(1.81 MB) Sequence of 60 images of the (a) cornea [Media 3] and (b) angle structures of the right eye of a human volunteer [Media 4]. Each image consists of 1024 depth profiles acquired at a frame rate of 43 frames per second.

(8.49 MB) Three dimensional tomography of the angle section of the right eye of a human volunteer. The movie is constructed from 60 frames each consist of 1024 depth profiles. The movie consists of 848×704×60 pixels and spans a volume (5×3.6×5) mm3 of the angle. [Media 5]