The National Institute of Neurological Disorders and Stroke (NINDS), the National Institute on Aging (NIA), and the National
Institute of Nursing Research (NINR) invite grant applications for research on the cognitive sequelae of Parkinson’s disease
(PD). This announcement is supported by 3 grant funding mechanisms: R01, R03, and R21.*

PD is commonly viewed as a movement disorder. However, it is more than a movement disease; it also affects thinking, reasoning,
learning, processing speed, and other cognitive abilities. The cognitive changes seen in people with PD are less understood
and studied than parkinsonian movement symptoms.

Areas of research interest include, but are not limited to: basic molecular or cellular studies of potential drugs or other
treatments that could address cognitive impairments in PD; behavioral and physiological characterization of models based on
the new molecular understanding of synuclein, parkin, and other proteins involved in the pathogenic processes of neurodegenerative
disorders; the neurobiological basis of cognitive impairments in PD; the association between clinical disease onset, neuropathology
in PD, and the development and severity of cognitive impairments; best outcome measures in PD patients with cognitive impairments,
or co-morbid with dementia, depression, or other non-motor manifestations, including development and validation of specific
assessment tools for PD patients with cognitive impairment; the relationship between age of onset of PD and PD-related cognitive
changes; neuroanatomical circuits and neurochemical processes mediating cognitive states and cognition-based individual differences
in PD; and the specific consequences of deep brain stimulation or other surgical interventions on the cognitive aspects of
PD.