A new endocrinology investigation suggests childhood abuse or neglect can lead to long-term hormone impairment that raises the risk of developing obesity, diabetes, or other metabolic disorders in adulthood.

The study is published in the Endocrine Society’s Journal of Clinical Endocrinology & Metabolism (JCEM).

For the study, researchers examined levels of the weight-regulating hormones leptin, adiponectin, and irisin in the blood of adults who endured physical, emotional, or sexual abuse or neglect as children.

Leptin is involved in regulating appetite and is linked to body-mass index (BMI) and fat mass. The hormone irisin is involved in energy metabolism. Adiponectin reduces inflammation in the body, and obese people tend to have lower levels of the hormone.

Researchers found that these important hormones were out of balance in people who had been abused or neglected as children.

“The data suggest that childhood adversity places stress on the endocrine system, leading to impairment of important hormones that can contribute to abdominal obesity well into adulthood.”

The cross-sectional study examined hormone levels in the blood of 95 adults ages 35 to 65. Using questionnaires and interviews, each participant was assigned a score based on the severity of the abuse or neglect experienced during childhood.

Researchers divided the participants into three groups and compared hormone levels in people with the highest adversity scores to the other two-thirds of the participants.

Participants with the highest adversity scores tended to have higher levels of leptin, irisin, and the inflammatory marker C-reactive protein in their blood. All of these markers are linked to obesity.

In addition, the group of people who suffered the most adversity tended to have lower levels of adiponectin, another risk factor for obesity.

Even after researchers adjusted for differences in diet, exercise, and demographic variables among the participants, high levels of leptin and irisin continued to be associated with childhood adversity.

“What we are seeing is a direct correlation between childhood adversity and hormone impairment, over and above the impact abuse or neglect may have on lifestyle factors such as diet and education,” Mantzoros said.

“Understanding these mechanisms could help health care providers develop new and better interventions to address this population’s elevated risk of abdominal obesity and cardiometabolic risk later in life.”