Benadryl is not a tricyclic antidepressant and not close to it. This would be a false-positive result. Fyi, benadryl does not easily cause a positive drug screen. If you haven't taken something else, it means you're taking way too much benadryl, practically toxic, to be causing a false positive. I suggest you lay off using it for sleep assistance - that's not healthy and not Benadryl's purpose.

People don't usually consider Benadryl a cough medicine. Compound wise, yes it counts as one, but most people associate it with allergies- runny nose, sinus pressure, itching, swelling, flushing, coughing, etc- rather than colds.

The fact that doctors do promote the use of Benadryl as both an anti-anxiety medication and as a sleep aid doesn't exactly help clear things up any.

Benadryl is not a tricyclic antidepressant and not close to it. This would be a false-positive result. Fyi, benadryl does not easily cause a positive drug screen. If you haven't taken something else, it means you're taking way too much benadryl, practically toxic, to be causing a false positive. I suggest you lay off using it for sleep assistance - that's not healthy and not Benadryl's purpose.

While Benadryl (Diphenhydramine) is not a tricyclic antidepressant, as mentioned already (thanks CRC_101), certain assays such as the enzyme immunoassay may show false positivity with Benadryl, especially at higher dosages, but usually not with a single pill ...