Members of relevant
gene families implicated in schizophrenia, in relation to the major processes
disrupted in the disease: (glutamatergic signaling,
dopamine, serotonin and GABA systems, oligodendrocyte function, growth-related
processes, and oxidative stress). For references see Schizophrenia
susceptibility genes

The genes implicated
in viral and pathogen life cycles are also illustrated. For references
see Schizophrenia
microbes

As a rough comparison,
the number of genes involved in each process is illustrated and also shown
as a percentage of schizophrenia-related genes to date (currently N= 245)

SLC6A4, MAOA, TPH1, YWHAH

16 =6.5%

Growth factor signaling:
Tyrosine kinases activate a phosphoinositide
kinase-signaling network culminating in the
activation of protein kinase B (AKT1).
These kinases and their diverse
phosphatidyl-phosphate
products are multifunctional and
play important roles in cellular signaling
and transport pathways.

Oxidative stress: Glutathione: Plays an important
role in the detoxification of dopamine/catecholamine derived quinones:
These are formed spontaneously and their formation can be limited by speeding
the metabolism of dopamine through enyme-mediated metabolism (monoamine
oxidase (MAOA, catechol-O-methyltransferase COMT).

CLOCK,
PER3, TIMELESS

3=1%

DISC1 :
Disrupted in schizophrenia 1 and binding partners

Important “Hub gene” at the centre of multiple processes;
Product binds to glutamate receptor scaffolds, the cytoskelatal and
microtubule network, proteins involved in growth development
and protein synthesis as well as to transcription factors involved in
oligodendrocyte development
and the control of stress pathways.

Binds to ATF4, DPYSL2, FEZ1, GABBR1, MLC1, NDE1, PDE4B

8=3.2%

Cytoskeletal components and transport

Tubulin related (MAP6, TUBA2)

BLOC-1 complex (Dysbindin (DTNBP1) Muted and
BLOC1S3.

Involved in endosome to lysosome transport

Kinesin KIF2A

PIK3C3, PI4KA, PIP5K2A

9=3.7%

Nuclear importins/karyopherins:
Transport cargoes from
the cytoplasm to the nucleus via nuclear pores.