Shimano's di2 fd is adjustable for start- and end-points, so the space between the rings is a non-issue there. (Eps is not as adjustable, but it's more conventional in spacing, so...)Auto-trim will work satisfactorily at worst. I agree that the motor is very strong, but unless you often shift without pedalling, i cant see that as a problem.Im gonna go ahead and say that di2 front derailleurs are the MOST tolerant derailleurs as far as mixed setups go.

Sorry, I am speaking of the sweep of the auto-trim feature. The difference between the Campagnolo and Shimano ring spacing is very close (0.2mm wider), but I wanted to be clear that I had never tried it with Di2.

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