This volume is intended to collect important research results to the lectures and discussions which took Place in Rome, at the INdAM Workshop on Different Notions of Regularity for Functions of Quaternionic Variables in September 2010. This volume will collect recent and new results, which are connected to the topic covered during the workshop. The work aims at bringing together international leading specialists in the field of Quaternionic and Clifford Analysis, as well as young researchers interested in the subject, with the idea of presenting and discussing recent results, analyzing new trends and techniques in the area and, in general, of promoting scientific collaboration. Particular attention is paid to the presentation of different notions of regularity for functions of hypercomplex variables, and to the study of the main features of the theories that they originate.