Levatol

OVERDOSE

There is no actual experience with levatol® overdose. The signs and symptoms that would be expected with overdosage of β-adrenergic receptor antagonists are symptomatic bradycardia, hypotension, bronchospasm, and acute cardiac failure. In addition to discontinuation of levatol®, gastric emptying, and close observation of the patient, the following measures might be considered as appropriate:

Excessive Bradycardia

Administer atropine sulfate to induce
vagal blockade. If bradycardia persists, intravenous isoproterenol hydrochloride
may be administered cautiously; larger than usual doses may be needed. In refractory
cases, the use of a trans venous cardiac pacemaker may be necessary.

Hypotension

Sympathomimetic drug therapy, such as dopamine,
dobutamine, or levarterenol, may be considered if hypotension persists despite
correction of bradycardia. In refractory cases, administration of glucagon hydrochloride
has been reported to be useful.

Bronchospasm

A β-2-agonist or isoproterenol hydrochloride may
be administered. Additional therapy with aminophylline may be considered.

Acute Cardiac Failure

Institute conventional therapy immediately.
Intravenous administration of dobutamine and glucagon hydrochloride has been
reported to be useful.

Heart Block (Second or Third Degree)

Isoproterenol hydrochloride
or a transvenous cardiac pacemaker may be used.