The peripheral layer of cells merged with the stroma that stained strongly with alcian blue... What is your diagnosis? Chondroid syringoma Chondroid syringoma (CS), also called as mixed tumor of skin, is a benign cutaneous adnexal tumor composed of epithelial and stromal elements and is predominantly seen in the head and neck regions... CS are usually benign but may rarely undergo malignant transformation... The malignant forms may arise de novo or may arise from incompletely excised lesion that has recurred... Although the diameter of malignant CS is usually more than 3 cm (range, 2–8 cm; mean, 4.8 cm), giant benign facial CS have also been reported... Therefore, lesions more than 3 cm in diameter should be followed up carefully on account of malignancy... The choice of management is complete surgical excision with a cuff of normal tissue, rather than simple shelling of lesion... To conclude, CS should be considered in the differential diagnosis of a nodular lesion on the skin of head and neck regions... Due to its rarity, the diagnosis is often overlooked, especially when considered preoperatively.

Mentions:
A 34-year-old man presented with an asymptomatic nodular mass on his right cheek of two years′ duration [Figure 1]. It initially appeared as a small papule that gradually increased to its present size. Physical examination revealed a firm, nontender bilobed tumor measuring 2.5 × 2 × 1 cm in size. There was no cervical lymphadenopathy. The tumor was mobile and distinct from surrounding structures. The differential diagnosis of dermatofibroma, pilomatricoma, and sebaceous cyst were considered. Surgically excised nodule was sent for histopathological examination. The patient was advised to come for follow-up.

Mentions:
A 34-year-old man presented with an asymptomatic nodular mass on his right cheek of two years′ duration [Figure 1]. It initially appeared as a small papule that gradually increased to its present size. Physical examination revealed a firm, nontender bilobed tumor measuring 2.5 × 2 × 1 cm in size. There was no cervical lymphadenopathy. The tumor was mobile and distinct from surrounding structures. The differential diagnosis of dermatofibroma, pilomatricoma, and sebaceous cyst were considered. Surgically excised nodule was sent for histopathological examination. The patient was advised to come for follow-up.

The peripheral layer of cells merged with the stroma that stained strongly with alcian blue... What is your diagnosis? Chondroid syringoma Chondroid syringoma (CS), also called as mixed tumor of skin, is a benign cutaneous adnexal tumor composed of epithelial and stromal elements and is predominantly seen in the head and neck regions... CS are usually benign but may rarely undergo malignant transformation... The malignant forms may arise de novo or may arise from incompletely excised lesion that has recurred... Although the diameter of malignant CS is usually more than 3 cm (range, 2–8 cm; mean, 4.8 cm), giant benign facial CS have also been reported... Therefore, lesions more than 3 cm in diameter should be followed up carefully on account of malignancy... The choice of management is complete surgical excision with a cuff of normal tissue, rather than simple shelling of lesion... To conclude, CS should be considered in the differential diagnosis of a nodular lesion on the skin of head and neck regions... Due to its rarity, the diagnosis is often overlooked, especially when considered preoperatively.