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Simone is a young woman who has been bitten by the zombies after losing her family and boyfriend to them. Frank finds her in a music store and tries to convince her to come back to the Security Room with him, promising that a helicopter is coming to rescue them.

She is initially skeptical and will only come back with Frank if there is a medical technician who can help her. After Frank learns that Isabela is a medical technician and she has been brought back to the security room, he will assure her there is someone at the security room who can help. She will agree to follow Frank and she can be escorted back to the security room. If not, then Simone will refuse to come and eventually die on her own.

Fearing that her eventual zombification will pose a problem for the other survivors, Simone requests Frank to bring her a handgun. If Frank accepts her wishes, she promises not to use it unless it is inevitable.

If you take a picture of her wound, the target markers will register as the Horror genre.

Simone sometimes disappears after Kent Swanson is defeated in Photographer's Pride, due to a possible glitch. Also, if Frank has 8 survivors with him, including Tad, she will not appear, despite Tad not counting towards the 8-survivor limit. [Verification needed]

It is unknown whether or not she became a zombie after she escaped from Willamette, although it is possible that she procured Zombrex, or that Isabela managed to treat the wound in time. Other possibilities include receiving medical care or she may have been forced to shoot herself before she became a zombie.