Marcus Semien's solo home run was the only Oakland Athletics run

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OAKLAND, CALIFORNIA – AUGUST 18: Starting pitcher Brett Anderson #30 of the Oakland Athletics looks at his hand as he leaves the game against the Houston Astros in the top of the sixth inning at Ring Central Coliseum on August 18, 2019 in Oakland, California. (Photo by Lachlan Cunningham/Getty Images)

Houston Astros pitcher Roberto Osuna, right, celebrates the 4-1 win over the Oakland Athletics with Robinson Chirinos at the end of a baseball game Sunday, Aug. 18, 2019, in Oakland, Calif. (AP Photo/Ben Margot)

Houston Astros’ Jose Altuve, right, is tagged out by Oakland Athletics catcher Josh Phegley in the first inning of a baseball game Sunday, Aug. 18, 2019, in Oakland, Calif. (AP Photo/Ben Margot)

Houston Astros pitcher Zack Greinke works against the Oakland Athletics in the first inning of a baseball game Sunday, Aug. 18, 2019, in Oakland, Calif. (AP Photo/Ben Margot)

OAKLAND, CALIFORNIA – AUGUST 18: Jose Altuve #27 of the Houston Astros is tagged out at home plate by catcher Josh Phegley #19 of the Oakland Athletics in the top of the first inning at Ring Central Coliseum on August 18, 2019 in Oakland, California. (Photo by Lachlan Cunningham/Getty Images)

Houston Astros pitcher Zack Greinke works against the Oakland Athletics in the first inning of a baseball game Sunday, Aug. 18, 2019, in Oakland, Calif. (AP Photo/Ben Margot)

Oakland Athletics’ Marcus Semien, right, is congratulated by third base coach Matt Williams (4) after hitting a home run off Houston Astros’ Zack Greinke in the fourth inning of a baseball game Sunday, Aug. 18, 2019, in Oakland, Calif. (AP Photo/Ben Margot)

Oakland Athletics pitcher Brett Anderson works against the Houston Astros in the first inning of a baseball game Sunday, Aug. 18, 2019, in Oakland, Calif. (AP Photo/Ben Margot)

Houston Astros’ Jose Altuve slides after being tagged out by Oakland Athletics catcher Josh Phegley in the first inning of a baseball game Sunday, Aug. 18, 2019, in Oakland, Calif. (AP Photo/Ben Margot)

Houston Astros’ Alex Bregman, right, is congratulated by Josh Reddick (22), Jose Altuve (27) and Yordan Alvarez after hitting a three run home run off Oakland Athletics’ Brett Anderson in the fifth inning of a baseball game Sunday, Aug. 18, 2019, in Oakland, Calif. (AP Photo/Ben Margot)

Houston Astros pitcher Roberto Osuna works against the Oakland Athletics in the ninth inning of a baseball game Sunday, Aug. 18, 2019, in Oakland, Calif. (AP Photo/Ben Margot)

OAKLAND, CALIFORNIA – AUGUST 18: Pitcher Brett Anderson #30 of the Oakland Athletics reacts after giving up a three-run home run to Alex Bregman of the Houston Astros in the top of the fifth inning at Ring Central Coliseum on August 18, 2019 in Oakland, California. (Photo by Lachlan Cunningham/Getty Images)

OAKLAND, CALIFORNIA – AUGUST 18: Alex Bregman #2 of the Houston Astros hits a three-run home run in the top of the fifth inning against the Houston Astros at Ring Central Coliseum on August 18, 2019 in Oakland, California. (Photo by Lachlan Cunningham/Getty Images)

OAKLAND, CALIFORNIA – AUGUST 18: Marcus Semien #10 of the Oakland Athletics celebrates in the dugout after hitting a solo home run in the bottom of the fourth inning against the Houston Astros at Ring Central Coliseum on August 18, 2019 in Oakland, California. (Photo by Lachlan Cunningham/Getty Images)

OAKLAND — The A’s couldn’t complete the four-game sweep against a tough division rival, losing 4-1 to the Houston Astros on Sunday afternoon.

Alex Bregman was churning out hard contact against Brett Anderson, first with a single and a 102 mph double. His third time up, Anderson went 0-2 early with a first-pitch fastball followed up with a slider. He’d go back to that same slider again, and Bregman met it with barrel for a three-run, go-ahead homer.

Bregman’s home run nullified Marcus Semien’s solo shot in the fourth inning. His 21st home run of the season gave the A’s a short-lived lead and dispensed of the perfect game Zack Greinke had been patching together on just 25 pitches through the first three innings.