Laboratory Study of Cannabidiol on the Effects of Smoked Marijuana

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The objective of this study is to assess the effects of oral cannabidiol (CBD; 0, 200, 400, 800 mg) on smoked marijuana's (0, 5.6% THC) subjective, reinforcing, cognitive, and cardiovascular effects. This experiment is expected to reveal CBD's intrinsic effects when combined with placebo marijuana, as well as its ability to modulate the behavioral effects of active marijuana.

Condition or disease

Intervention/treatment

Phase

Smoking, Marijuana

Drug: CBD

Phase 2

Detailed Description:

Marijuana contains many chemicals called cannabinoids. The ingredient mainly responsible for marijuana's psychoactive effects is called THC (delta-9-tetrahydrocannabinol. Another cannabinoid in marijuana is cannabidiol. It is found in smaller quantities than THC. Cannabidiol is thought to interfere with the effects of THC. Therefore, synthetically produced cannabidiol is given to healthy marijuana users in this study to test its capability to reduce the high of THC and, thereby, help to relieve addiction to marijuana.

Each subject in the study was tested on eight days, each day receiving a different combination of active/inactive cannabis cigarettes plus 0, 200, 400 or 800 mg of CBD in random order. Cigarettes contained either 0.01 or 5.30% THC. At each visit, participants were given four gelatin capsules containing lactose and 0 or 200 mg of CBD in combinations to achieve scheduled dose level.

Other Name: cannabidiol is abbreviated CBD

Active MJ with 200 mg CBD

Active MJ cigarettes contain 5.30% THC

Drug: CBD

Each subject in the study was tested on eight days, each day receiving a different combination of active/inactive cannabis cigarettes plus 0, 200, 400 or 800 mg of CBD in random order. Cigarettes contained either 0.01 or 5.30% THC. At each visit, participants were given four gelatin capsules containing lactose and 0 or 200 mg of CBD in combinations to achieve scheduled dose level.

Other Name: cannabidiol is abbreviated CBD

Active MJ with 400 mg CBD

Active MJ cigarettes contain 5.30% THC

Drug: CBD

Each subject in the study was tested on eight days, each day receiving a different combination of active/inactive cannabis cigarettes plus 0, 200, 400 or 800 mg of CBD in random order. Cigarettes contained either 0.01 or 5.30% THC. At each visit, participants were given four gelatin capsules containing lactose and 0 or 200 mg of CBD in combinations to achieve scheduled dose level.

Other Name: cannabidiol is abbreviated CBD

Active MJ with 800 mg CBD

Active MJ cigarettes contain 5.30% THC

Drug: CBD

Each subject in the study was tested on eight days, each day receiving a different combination of active/inactive cannabis cigarettes plus 0, 200, 400 or 800 mg of CBD in random order. Cigarettes contained either 0.01 or 5.30% THC. At each visit, participants were given four gelatin capsules containing lactose and 0 or 200 mg of CBD in combinations to achieve scheduled dose level.

Other Name: cannabidiol is abbreviated CBD

Inactive MJ with 0 mg CBD

Inactive MJ cigarettes contain 0.01% THC

Drug: CBD

Each subject in the study was tested on eight days, each day receiving a different combination of active/inactive cannabis cigarettes plus 0, 200, 400 or 800 mg of CBD in random order. Cigarettes contained either 0.01 or 5.30% THC. At each visit, participants were given four gelatin capsules containing lactose and 0 or 200 mg of CBD in combinations to achieve scheduled dose level.

Other Name: cannabidiol is abbreviated CBD

Inactive MJ with 200 mg CBD

Inactive MJ cigarettes contain 0.01% THC

Drug: CBD

Each subject in the study was tested on eight days, each day receiving a different combination of active/inactive cannabis cigarettes plus 0, 200, 400 or 800 mg of CBD in random order. Cigarettes contained either 0.01 or 5.30% THC. At each visit, participants were given four gelatin capsules containing lactose and 0 or 200 mg of CBD in combinations to achieve scheduled dose level.

Other Name: cannabidiol is abbreviated CBD

Inactive MJ with 400 mg CBD

Inactive MJ cigarettes contain 0.01% THC

Drug: CBD

Each subject in the study was tested on eight days, each day receiving a different combination of active/inactive cannabis cigarettes plus 0, 200, 400 or 800 mg of CBD in random order. Cigarettes contained either 0.01 or 5.30% THC. At each visit, participants were given four gelatin capsules containing lactose and 0 or 200 mg of CBD in combinations to achieve scheduled dose level.

Other Name: cannabidiol is abbreviated CBD

Inactive MJ with 800 mg CBD

Inactive MJ cigarettes contain 0.01% THC

Drug: CBD

Each subject in the study was tested on eight days, each day receiving a different combination of active/inactive cannabis cigarettes plus 0, 200, 400 or 800 mg of CBD in random order. Cigarettes contained either 0.01 or 5.30% THC. At each visit, participants were given four gelatin capsules containing lactose and 0 or 200 mg of CBD in combinations to achieve scheduled dose level.

Subjects rated how strong the effects of the cannabis were using a visual analog scale.

Optional Additional Puffs of MJ Cigarette [ Time Frame: 150 to 250 minutes after first marijuana cigarette was smoked earlier in the day ]

Participants were allowed to choose to take or reject additional puffs of the same type of MJ cigarette they smoked earlier in the day. Counts of participants choosing to take additional puffs are reported.

Number of Optional Puffs of MJ Cigarette Taken [ Time Frame: 150 to 160 minutes after first marijuana cigarette was smoked earlier in the day ]

Mean number of puffs taken by those participants who chose to take additional puffs.

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Layout table for eligibility information

Ages Eligible for Study:

18 Years to 50 Years (Adult)

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

No

Criteria

Inclusion Criteria:

Adults between the ages of 18 and 50.

Current marijuana use: Minimum of four times per week, 0.5 joints per occasion during the preceding 4 weeks.