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When his Final Smash activates, Snake will say "It's showtime!" (ショータイム！, Showtime!) as he leaps off the stage and grabs onto a rope ladder of a helicopter. The camera becomes an over-the-shoulder view and the player can aim with a crosshair, much like the Dragoonitem, to make Snake shoot grenades at his opponents by pressing an attack button. Each grenade does approximately 18% damage. Snake can fire up to two clips with six grenades; after firing six shots, he loads a new clip. If no rounds are fired within a few seconds, the Grenade Launcher begins to fire automatically. The Final Smash ends when Snake runs out of time or uses all twelve grenades.

Solid Snake is able to use a Grenade Launcher in various Metal Gear games. Snake first used a grenade launcher in the original Metal Gear for MSX and then in Metal Gear Solid 2: Sons of Liberty. However, it is only a modification for the M4 carbine assault rifle. This particular weapon is taken from Metal Gear Solid 2. The model of Snake's grenade launcher is based on the "RGB6" (based on the real-life Milkor MGL). However, in Metal Gear Solid 2, Snake's grenade launcher was mounted on a rifle. The overall concept of the attack is derived from an event in the same game - at one point during the story, Snake shoots grenades at a Harrier jet controlled by Solidus Snake and Vamp from the passenger area of a Kasatka helicopter. It is thought that the person flying the helicopter Snake rides on is Otacon, as he did in the game.

Snake's Final Smash. He grabs a ladder hanging from a helicopter and appears in the foreground, then fires a grenade launcher at foes. The grenades explode on impact and damage anyone in the vicinity. Each clip holds six grenades--empty one, and Snake reloads. He can fire a total of twelve shots, but with such limited time, it's better to shoot 'em all.

The line Snake delivers when he performs the Final Smash is the same one he gave when he first revealed himself as a newcomer in the E3 trailer (although, in the trailer, Snake only speaks in Japanese).

On the trophy of the Final Smash, the grenades are bigger than the barrel, and there is no hole for them to be shot out of.

When Snake has a Smoke Ball emitting smoke on him when using his Final Smash, the entire screen will be covered with smoke, making it one of the two "Smoking" Final Smashes, the other one being Volt Tackle.

If one pauses the game while Snake uses Grenade Launcher and moves the camera in any way, Snake will vanish from the screen. This is similar to Peach Blossom.

If the Ultimate Chimera appears while the Final Smash is active, the background will be dark instead of blue-toned.

The number of shots capable of being fired might be a reference to Revolver Ocelot's Colt Single Action Army Revolver, his signature weapon, which usually holds 6 bullets, the amount that Snake's launcher can fire before reloading. The maximum number of shells allowed during this Final Smash is a reference to the boss battle against Ocelot in Snake Eater wherein he has two revolvers and thus, "12 shots".