Miracle of Science (sci-fi with some original ideas)
Absurd Notions (realistic comic. Doesn't update often, but pretty good)
Mindmistress (superhero comic, retro style)
Ozy and Millie (fun and cute, despite tons of politics)
PvP (gaming strip)
Sluggy Freelance (can't be explained. Must be seen with your own eyes)
Fans (One of the best comics out there, but it's on Graphic Smash, meaning most of the archives can't be read without paying subscription. Worth every cent, though)
Saga of the Ram (superhero comic. Graphic Smash)
Nukees (comic about nuclear engineering students. What's not to like?)
Schlock Mercenary (Military Science Fiction)
Bruno the Bandit (sorta-fantasy. Absolutely hilarious)
CRFH (among the best and weirdest)
GPF (Geek humour, but can be enjoyed even without understanding the technical jokes)
Gaming Guardians (superheros meet RPGs)
It's Walky (one of the few that can compete with Fans or CRFH for best comic)
Aside from that...Kevin and Kell. Planet Earth and Other Tourist Traps. Faux Pas. No Need for Bushido. Under the Lemon Tree. Nip and Tuck. Tale of the Questor. User Friendly. I Drew This. As If. Penny and Aggie. Killroy and Tina. The Guardians. Aces High. Ascent. Digger. Rip & Teri. Sinfest. Sore Thumbs. Alice. Antihero for Hire. Clan of the Cats. Funny Farm. Gene Catlow. Help Desk. Melonpool.