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Chemsex is identified in the film as the habit of engaging in weekend-long parties fuelled by sexually disinhibiting drugs, such as crystal meth, GHB, GBL and mephedrone. These parties involve multiple people and are mostly facilitated online. The testimonies in the film from people involved in the subculture directly link chemsex to alarming rates of HIV infection. In London four new positive diagnoses are currently made daily. There is candid talk on film about “pozzing up”, the practise of knowingly becoming infected with the virus. Meth, meph and G create a potent cocktail enabling extremes of behaviour, which carries significant risks for the sexual and mental health of habitual users.

U.K. media and government officials are sounding the alarm over something called "chemsex," which involves—are you ready for this newfangled idea?—taking mind-altering substances and then having sex. Oblivious that they're describing something that has happened for literally all of time, British officials warn that "taking recreational drugs during sex can lead to a number of potentially harmful side effects including facilitating the spread of common STIs and HIV, but also serious mental health problems, such as anxiety, psychoses and suicidal tendencies."