South Park's early episodes tended to be shock value-oriented and featured more Pythonesque humor than later episodes. Although satire had been used on the show occasionally in its early and middle years, it became more evident around the eighth season. Episodes have parodied Michael Jackson (in "The Jeffersons"), Paris Hilton ("Stupid Spoiled Whore Video Playset"), The Passion of the Christ (in "The Passion of the Jew"), and American immigration policy ("Goobacks").

The pilot episode ("Cartman Gets an Anal Probe") required three months to produce using construction paper and traditional cut-out animation techniques. However the version that aired was different from the original version. Current episodes duplicate the original, amateurish look using modern computer animation tools — first PowerAnimator and then Maya, which Parker and Stone described as "building a sandcastle with a bulldozer". This allows for a shorter production schedule, enabling the creators to respond quickly to current events. The December 17, 2003 episode "It's Christmas in Canada" depicted the capture of Saddam Hussein a mere three days after the actual event, even referring to the "spider hole" in which he was found. In this instance -- as with the Elián González episode ("Quintuplets 2000") -- the creators changed the production of an episode at the last minute to focus on the new world event.