Usually the immune system is able to discriminate between foreign substances ("non-self") and the body’s own cells ("self"). It produces antibodies only when it perceives that it has been exposed to a threat ("non-self"), such as bacteria or viruses. However, when the immune system ceases to recognize one or more of the body's normal constituents as "self," it may produce autoantibodies that react with its own cells, tissues, and/or organs. This may cause inflammation, damage, and/or dysfunction of organs or systems, leading to signs and symptoms of autoimmune disorders.

Synonyms (Also knowns as)

ENA profile.

ANA profile.

Specimen Type and Minimal Volume

Human serum or EDTA, heparin or citrate plasma.

Forms

Not required

Test Equipment

Manual method

Test Method

Manual method

Reference Range

Qualitative results with ( 1 + to 3+ )

Include Test

N/A

Reporting Time (Turn Around Time; TAT)

1 day

Clinical Information

Human autoantibodies of the immunoglobulin class IgG to the 15 different antigens in serum or plasma to support the diagnosis of sharp syndrome(MCTD),systemic lupus erythematous (SLE), sjogren syndrome, progressive systemic sclerosis, poly-dermatomyositis ,overlap syndromes, limited form of CREST syndrome, primary biliary cholangitis.