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In response to SPRINT (Systolic Blood Pressure Intervention Trial), Hypertension Canada–Canadian Hypertension Education Program guidelines recommend that all patients with hypertension and high cardiovascular risk keep their systolic blood pressure (SBP) at 120 mm Hg or lower (1, 2). As more guidelines are updated, other organizations likely will advocate for more-intensive SBP targets in selected, high-risk patients. Given that the current SBP treatment goal of less than 140 mm Hg is already inadequately met, many clinicians will struggle with how to achieve the newer, more-intensive target in appropriate patients.