Interpretive Summary: Chemical extracts of equatorial rain forest tree, Macaranga monandra, of Cameroon showed antifungal activity to several Colletotrichum spp. using a simple bioautographic screening technique. Two clerodane-type diterpenes were separated, identified, and shown to possess antifungal activity to Phomposis viticola and Botrytis cinerea in a 96-well plate assay. However, because of their low antifungal activity we believe these compounds do not play a direct role in defense against fungal pathogenesis.