Tools

"... 8 ABSTRACT: Accurate determination of protein−ligand bind-9 ing affinity is a fundamental problem in biochemistry useful for 10 many applications including drug design and protein−ligand 11 docking. A number of scoring functions have been proposed 12 for the prediction of protein−ligand binding affi ..."

integrates two physico-18 chemical properties for protein−ligandbindingaffinity 19 prediction. One is the property of β contacts. A β contact 20 between two atoms requires no other atoms to interrupt the 21 atomic contact and assumes that the two atoms should have enough direct contact area. The other

"... The paper deals with the identification of binding sites and concentrates on interactions involving small interfaces. In particular we focus our attention on two major interface types, namely protein-ligand and protein-peptide interfaces. As concerns protein-ligand binding site prediction, we classi ..."

surface. Methods falling into class (b) address the prediction problem as an alignment problem, i.e. finding protein-ligand atom pairs that occupy spatially equivalent positions. Graph theoretic approaches, class (c), are mainly based on the definition of a particular graph, known as the proteincontact

"... Complex networks describe a wide range of systems in nature and society, much quoted examples including the cell, a network of chemicals linked by chemical reactions, or the Internet, a network of routers and computers connected by physical links. While traditionally these systems were modeled as ra ..."

Complex networks describe a wide range of systems in nature and society, much quoted examples including the cell, a network of chemicals linked by chemical reactions, or the Internet, a network of routers and computers connected by physical links. While traditionally these systems were modeled

"... Schultz, Wolfram. Predictive reward signal of dopamine neurons. is called rewards, which elicit and reinforce approach behav-J. Neurophysiol. 80: 1–27, 1998. The effects of lesions, receptor ior. The functions of rewards were developed further during blocking, electrical self-stimulation, and drugs ..."

Schultz, Wolfram. Predictive reward signal of dopamine neurons. is called rewards, which elicit and reinforce approach behav-J. Neurophysiol. 80: 1–27, 1998. The effects of lesions, receptor ior. The functions of rewards were developed further during blocking, electrical self-stimulation, and drugs

"... The actin cytoskeleton mediates a variety of essential biological functions in all eukaryotic cells. In addition to providing a structural framework around which cell shape and polarity are defined, its dynamic properties provide the driving force for cells to move and to divide. Understanding the b ..."

). In Swiss 3T3 fibroblasts, it was shown that Rho can be activated by the addition of extracellular ligands [for example, lysophos-phatidic acid] and that Rho activation leads to the assembly of contractile actin-myosin filaments (stress fibers) and of associated focal adhesion complexes (Fig. 1, C and D) (1

"... The availability of massive amounts of DNA sequence information has begun to revolutionize the practice of biology. As a result, current large-scale sequencing output, while impressive, is not adequate to keep pace with growing demand and, in particular, is far short of what will be required to obta ..."

to obtain the 3-billion-base human genome sequence by the target date of 2005. To reach this goal, improved automation will be essential, and it is particularly important that human involvement in sequence data processing be significantly reduced or eliminated. Progress in this respect will require both

"... This paper describes the Structure-Mapping Engine (SME), a program for studying analogical processing. SME has been built to explore Gentner's Structure-mapping theory of analogy, and provides a "tool kit" for constructing matching algorithms consistent with this theory. Its flexibili ..."

flexibility enhances cognitive simulation studies by simplifying experimentation. Furthermore, SME is very efficient, making it a useful component in machine learning systems as well. We review the Structure-mapping theory and describe the design of the engine. We analyze the complexity of the algorithm

"... This book presents a unified treatment of many different kinds of planning algorithms. The subject lies at the crossroads between robotics, control theory, artificial intelligence, algorithms, and computer graphics. The particular subjects covered include motion planning, discrete planning, planning ..."

"... Abstruct- A method for rapid visual recognition of personal identity is described, based on the failure of a statistical test of independence. The most unique phenotypic feature visible in a person’s face is the detailed texture of each eye’s iris: An estimate of its statistical complexity in a samp ..."

Abstruct- A method for rapid visual recognition of personal identity is described, based on the failure of a statistical test of independence. The most unique phenotypic feature visible in a person’s face is the detailed texture of each eye’s iris: An estimate of its statistical complexity in a