Introduction

Uses for Chlorzoxazone

Muscular Conditions

Adjunct to rest, physical therapy, analgesics, and other measures for the relief of discomfort associated with acute, painful musculoskeletal conditions.ai

If pharmacologic therapy is required for acute low back pain (usually a benign and self-limiting condition105106108 ), an analgesic (e.g., acetaminophen, NSAIA) generally is recommended.104105106108117 Skeletal muscle relaxants may be used alone or in combination with analgesics for short-term relief; however, consider high incidence of adverse effects (e.g., CNS effects).104106107108 Use skeletal muscle relaxants with caution and weigh risks against benefits.104106107108

Various skeletal muscle relaxants appear to have comparable efficacy for low back pain relief.103104106108

Chlorzoxazone is ineffective in the treatment of skeletal muscle hyperactivity secondary to chronic neurologic disorders (e.g., cerebral palsy) and other dyskinesias.b

CNS Effects

Performance of activities requiring mental alertness or physical coordination may be impaired.ai

Concurrent use of other CNS depressants may potentiate CNS depression.ai (See Specific Drugs under Interactions.)

Sensitivity Reactions

Sensitivity reactions (e.g., urticaria, redness, petechiae, pruritus) reported rarely; angioedema and anaphylactic reactions are extremely rare.ai Use with caution in patients with allergies or with a history of allergic drug reactions.abi

Half-life

Stability

Storage

Oral

Tablets

Actions

Inhibits multisynaptic reflex arcs at the level of the spinal cord and subcortical areas of the brain; results in reduction of skeletal muscle spasm with relief of pain and increased mobility of involved muscles.ai