Dry conditions have caused the Aral Sea's eastern lobe to completely dry up for the first time in modern history. It was once the fourth largest lake in the world, but owing to a disastrous irrigation project, it's all but gone.

By 2001, the southern connection had been severed, and the shallower eastern part retreated rapidly over the next several years. Especially large retreats in the eastern lobe of the Southern Sea appear to have occurred between 2005 and 2009, when drought limited and then cut off the flow of the Amu Darya. Water levels then fluctuated annually between 2009 and 2014 in alternately dry and wet years. Dry conditions in 2014 caused the Southern Sea's eastern lobe to completely dry up for the first time in modern times.

As the lake dried up, fisheries and the communities that depended on them collapsed. The increasingly salty water became polluted with fertilizer and pesticides. The blowing dust from the exposed lakebed, contaminated with agricultural chemicals, became a public health hazard. The salty dust blew off the lakebed and settled onto fields, degrading the soil. Croplands had to be flushed with larger and larger volumes of river water. The loss of the moderating influence of such a large body of water made winters colder and summers hotter and drier.