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Expression of the ITCH gene, encoding the E3 ubiquitin-protein ligase ITCH, is directly stimulated by binding of the complex of RUNX1 and YAP1 to the ITCH promoter (Levy, Reuven and Shaul 2008).ITCH is an important regulator of hematopoietic stem cell (HSC) function and homeostasis. ITCH reduces the proliferation rate of HSCs by downregulating NOTCH1 (Rathinam et al. 2011).