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EFFECT OF CYCLOOXYGENASE INHIBITORS ON RAT ROOT
RESORPTION AND TOOTH MOVEMENT
by
Timothy D. Brunson, DDS
____________________________________________________________________
A Thesis Presented to the
FACULTY OF THE GRADUATE SCHOOL
UNIVERSITY OF SOUTHERN CALIFORNIA
In Partial Fulfillment of the
Requirements for the Degree
MASTER OF SCIENCE
(CRANIOFACIAL BIOLOGY)
May 2008
Copyright 2008 Timothy D. Brunson, DDS

Purpose: The purpose of this study was to compare the effects of ibuprofen, a conventional NSAID, and celebrex, a COX-2 specific inhibitor, on tooth movement and root resorption. Methods: 49 female wistar rats were placed into 5 groups: (1) control (no dosage), (2) high dose celebrex (80mg/kg body weight), (3) high dose ibuprofen (50 mg/kg), (4) low dose celebrex (40 mg/kg), and (5) low dose ibuprofen (25 mg/kg). Rats were anesthetized by IP injection of Phenobarbital (0.1 mg/gm body weight), and a force of 80 grams was applied to the maxillary left first molars using a nickel titanium closed-coil spring. Tissue samples analyzed by light microscopy, and areas of resorption were quantified. Results: Ibuprofen and celebrex reduced resorption compared to control. High dose celebrex caused a reduction of tooth movement. Conclusions: There is minimal advantage in using selective COX-2 inhibitors to limit resorption; however, treatment time may be lengthened.

EFFECT OF CYCLOOXYGENASE INHIBITORS ON RAT ROOT
RESORPTION AND TOOTH MOVEMENT
by
Timothy D. Brunson, DDS
____________________________________________________________________
A Thesis Presented to the
FACULTY OF THE GRADUATE SCHOOL
UNIVERSITY OF SOUTHERN CALIFORNIA
In Partial Fulfillment of the
Requirements for the Degree
MASTER OF SCIENCE
(CRANIOFACIAL BIOLOGY)
May 2008
Copyright 2008 Timothy D. Brunson, DDS