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Integrated Circuits in space suffer from reliability problems due to the radiative surroundings. High energy particles can ionize the semiconductor and lead to single event effects. For digital systems, the transients can upset the logic values in the storage cells which are called single event upsets, or in the combinational logic circuits which are called single event transients. While for analog systems, the transient will introduce noises and change the operating point. The influence becomes more notable in advanced technologies, where devices are more susceptive to the perturbations due to the compact layout. Recently radiation-hardened-by-design has become an effective approach compared to that of modifying semiconductor processes. Hence it is used in this thesis project. Firstly, three elaborately designed radiation-tolerant registers are implemented. Then, two built-in testing circuits are introduced. They are used to detect and count the single event upsets in the registers during high-energy particle tests. The third part is the pulse width measurement circuit, which is designed for measuring the single event transient pulse width in combinational logic circuits. According to the simulations, transient pulse width ranging from 90.6ps to 2.53ns can be effectively measured. Finally, two frequently used cross-coupled LC tank voltage-controlled oscillators are studied to compare their radiation tolerances. Simulation results show that the direct power connection and transistors working in the deep saturation mode have positive influence toward the radiation tolerance. All of the circuit designs, simulations and analyses are based on STMicroelectronics CMOS 90 nm 7M2T General Process.