http://www.tjsr.org/journal/index.php/tjsr/issue/feedTrends Journal of Sciences Research2019-08-24T11:02:03+02:00Jardae Greeneditor@tjsr.orgOpen Journal Systemshttp://www.tjsr.org/journal/index.php/tjsr/article/view/111 Perioperative Antiviral Treatment Facilitate the Postoperative Recovery for Patients with HBV Related to Hepatocellular Carcinoma2019-03-01T15:15:57+01:00Zhiping Li247546160@qq.comLiping Lei247546160@qq.comJianhua Gong247546160@qq.comJunyi Wang247546160@qq.comBo Li247546160@qq.comChunmei Zhou247546160@qq.comJingfa Li247546160@qq.com<p><strong>Objective: </strong>This study aimed to determine whether perioperative antiviral treatment is <a href="http://dict.youdao.com/w/facilitate/#keyfrom=E2Ctranslation">facilitate</a> for patients with hepatitis B (HBV)-related hepatocellular carcinoma (HCC) and Child-Pugh grade A cirrhosis in perioperative recovery of liver function and HBV activation.</p> <p><strong>Methods:</strong> The study included 115 patients with HBV-related HCC and Child-Pugh grade A cirrhosis who underwent resection. Patients were prospectively assigned to a preoperative antiviral treatment group (<em>n</em> = 51) or postoperative antiviral treatment group (<em>n</em> = 52); twelve patients who had not received antiviral treatment before and after surgery were designated a non-treatment group (<em>n</em> = 12). HBV reactivation during a month after the operation was defined as a HBV DNA value tenfold over preoperative values. Postoperative liver dysfunction was defined as prothrombin activity &lt;50% and serum bilirubin &gt;50 mmol/L on postoperative day 5.</p> <p><strong>Results:</strong> Postoperatively, liver dysfunction was present in 1 of 51 (1.96%) patients who received preoperative antiviral therapy, 1 of 52 (1.92%) who received postoperative therapy, and 3 of 12 (25%) who received no antiviral therapy. HBV reactivation postoperatively occurred at similar rates.</p> <p><strong>Conclusions:</strong> Preoperative and postoperative antiviral treatment of patients with Child-Pugh grade A cirrhosis and high levels of HBV DNA undergoing hepatic resection for HCC are both <a href="http://dict.youdao.com/w/facilitate/#keyfrom=E2Ctranslation">facilitate</a> in preventing perioperative liver dysfunction and reactivation of HBV. Thus, in this population with high levels of HBV DNA, perioperative antiviral treatment is important.</p>2019-03-01T15:15:51+01:00##submission.copyrightStatement##http://www.tjsr.org/journal/index.php/tjsr/article/view/120 Role of CTSC in Glioblastoma Based on Oncomine and TCGA Database2019-08-24T11:02:03+02:00Xinjie Ninningxinjie@163.comJuncheng Luoningxj3@mail.sysu.edu.cnGengqiang Lingningxj3@mail.sysu.edu.cnXiaochun Zhongningxj3@mail.sysu.edu.cnShoulian Zhengningxj3@mail.sysu.edu.cnJian Guoningxj3@mail.sysu.edu.cnQingchang Liuningxj3@mail.sysu.edu.cnBinchu Xuningxj3@mail.sysu.edu.cn<p><strong>Background and objective</strong> Glioblastoma (GBM) is one of the malignant tumors causing death worldwide. Most patients were found in the middle and late stages and had poor prognosis. The purpose of this study was to investigate the expression and significance of CTSC in GBM.</p> <p><strong>Methods</strong> The information about CTSC in Oncomine database was collected and analyzed twice. The role of CTSC in GBM was meta-analyzed. The expression of CTSC in glioma cell lines was retrieved by CCLE database, and the survival of patients was analyzed by TCGA database.</p> <p><strong>Results</strong> A total of 1,459 different types of CTSC were collected in Oncomine database, 134 of which had statistical differences in CTSC expression, 89 of which had increased CTSC expression and 45 of which had decreased CTSC expression. A total of 50 studies involving the expression of CTSC in GBM cancer and normal tissues included 1,189 samples.</p> <p>Compared with the control group, CTSC was highly expressed in GBM (P &lt; 0.05). Moreover, CTSC was highly expressed in glioma cell lines. There was a correlation between the expression of CTSC and the overall survival rate of GBM. The overall survival rate of patients with high expression of CTSC was worse, while the prognosis of patients with low expression of SPC24 was better (P &lt; 0.05).</p> <p><strong>Conclusion </strong>Through the in-depth mining of oncomine gene chip database, we propose that CTSC is highly expressed in GBM tissues and is related to the prognosis of GBM, which may provide an important theoretical basis for the treatment of glioma.</p>2019-08-24T11:02:00+02:00##submission.copyrightStatement##http://www.tjsr.org/journal/index.php/tjsr/article/view/119 Responses of Hydroponically Grown Sorghum (Sorghum bicolor L.M) to Zinc (Zn) Stress2019-06-24T11:37:07+02:00Hamza Badamasihamza.badamasi@fud.edu.ngMuhammad Saminu Dagaridagaribuk@gmail.com<p>Abiotic stress especially due heavy metals is one of the major environmental problems that threatens food security and pose greater risks to human health worldwide. In this research, greenhouse hydroponic experiments were carried out to study the morphological and biochemical responses of <em>Sorghum bicolor L.M </em>to different Zinc (Zn) levels. Two-week-old seedlings transplanted in hydroponic solutions were treated with different doses of Zn in the concentration ranges of 5, 25, 50, 100 and 200 mg/L supplied as ZnSO<sub>4</sub>. 5H<sub>2</sub>O. After 21 day of culture, the plants were harvested, blotted to dryness and separated into roots and shoots. The root and shoot lengths, dry weights and non-enzymatic biochemical parameters such as proline, Chlorophyll a, b, Carotenoids (pigments) were determined. The results indicate that Zn applications significantly (<em>P</em>&lt;0.05) depressed the lengths of root and shoot, dry weights and pigment contents compared to untreated plants (control). The effects were more pronounced with increased Zn dosage. The accumulation of the metal and proline contents in treated plants however, increase gradually with increasing Zn concentrations (<em>P</em>&lt;0.05). The changes in these parameters had resulted in toxicity symptoms and overall growth retardation especially at elevated concentrations and the estimated critical toxicity thresholds in both solution and tissue concentrations suggest that <em>sorghum bicolor L.M</em> should not be grown beyond Zn concentration of above 3.2 mg/L.</p> <p><em>&nbsp;</em></p>2019-06-24T11:28:15+02:00##submission.copyrightStatement##http://www.tjsr.org/journal/index.php/tjsr/article/view/110 Epstein - Barr Virus Capsid Antigen (EBV-VCA) IgM Antibodies among HIV Infected Individuals in Jos, Nigeria.2019-03-01T14:35:44+01:00Joseph Anejo-Okopijosephokopi@yahoo.comOcheme Julius Okojokwujosephokopi@yahoo.comNenkimwa Adamujosephokopi@yahoo.comJuliet Ogbonnajosephokopi@yahoo.comJoshua Adetunjijosephokopi@yahoo.comGabriel Odugbo Ikwulonojosephokopi@yahoo.com<p>Human immunodeficiency virus (HIV) infection is associated with an increased risk for Viral infections such as Epstein-Barr virus (EBV)infections also known as Human Herpes Virus Type 4 (HHV-4) and their related diseases which frequently cause malignancy related diseases resulting to poor treatment and health outcomes. In this study, we determined the seroprevalence of EBV VCA IgM antibodies among HIV patients attending Plateau Specialist Hospital, Jos, Nigeria and to evaluate their association with age, sex as well as other demographic factors. A total of 92 HIV positive patients were enrolled and serum samples were screened for antibodies using the ELISA kit. The prevalence of EBV VCA IgM was 6/92(6.53%), and mean age of 37.48 ±1.01 years. This study has contributed to baseline data, and suggest the need for larger studies and importance of screening and treatment of EBV among HIV patients.</p>2019-03-01T14:35:40+01:00##submission.copyrightStatement##http://www.tjsr.org/journal/index.php/tjsr/article/view/109 A Tool for Reporting and Evaluation of Incidents in External Beam Radiation Therapy2019-03-01T13:12:42+01:00André Luis de Carvalho Ribeiroandhreluiz@gmail.comFlavia Cristina da Silva Teixeiraflavia@cnen.gov.brEduardo De Paivaedup2112@gmail.com<p>The number of cases of cancer has significantly increased in the world and the use of ionizing radiation produced by large clinical linear accelerators plays an important role in the treatment of tumors. Although radiotherapy is considered a safe medical practice, it may bring some risks for the patient and in some extreme cases even her/his death. Over the last decades, the learning with incidents there has been a powerful way to prevent them to turn to happen. In this work a digital tool was developed for recording and evaluation of incidents in external beam radiation therapy. The tool was designed to function in an intranet environment, but it can also be used in the offline mode and is based on a set of sequential forms filled by the user (e.g. medical physicists, medical dosimetrists, radiation oncologists, radiotherapy technicians). The software was firstly applied in a radiation oncology department of a public Institution in Rio de Janeiro, Brazil. The software has proved to be an important and promising tool to improve the healthcare quality of patients undergoing radiation therapy.</p>2019-03-01T13:10:02+01:00##submission.copyrightStatement##