#Postdevelopmental inactivation of 377 first-order LAG interactors in the WLN and HLN identified
#104 candidates that conferred an increase in survival, and 55 a decrease. To subject candidates
#to a more rigorous assessment of lifespan, 60 candidates (48 long-lived and 12 short-lived)
#were inactivated postdevelopmentally in an enhanced RNAi mutant, eri-1. Survival was scored
#on alternate days and significance was determined by Kaplan-Meier analysis with a threshold of
#p<0.05. Our analysis confirmed the phenotypes of 33 new regulators of longevity, 22 that
#increase longevity and 11 that shorten it, listed here with their network association (worm or
#human longevity network), gene identifications, percentage change mean lifespan in
#comparison to an empty vector RNAi control, and functional annotations. Annotations suggest
#that these genes contribute to diverse biological functions, such as translation and energy
#metabolism, disruption of which is strongly associated with longevity extension and endocytosis,
#which has been identified as a requirement for lifespan extension downstream of insulin/IGF-1
#signaling.