People like this bother me. While Glocks ARE good guns, IMHO they are far from being the best. There are many gun that are just as good and better than Glocks and 1911's. Don't get me wrong, The 1911 is as good as it gets, tried and true, war proven for almost 100 years. Just not for me.
Of the guns listed I would chooes the Ruger, but I'm waiting for the reviews of the Sig 250. I personally have a Witness P Compact .45. Grip was a little thin so I made 1/4" thick mahogany panels to attach and now it fits quite well and looks good too! No malfunctions and the CZ design is infallable.

Don't knock florida1098 for preferring Glock. He never said it was best for everyone, just that it is what he prefers and what he will buy.

The only service pistols I'll carry are also Glocks, because in my opinion they are the best design on the current market. I acknowledge that there are many other good guns on the market, but I will only buy Glocks (in service-type pistols).

And CZs are hardly infallible. My experience is that they are very reliable pistols, but not quite as reliable as Glock.

My Aunt just got a Compact HK USP and It is very bulky but it really does shoot very well. I was also able to shoot a Sig p226 in 45 and thats also very nice fire arm.

the USP had a large grip that's for sure. Try the HK45 and HK45c. They have user replaceable back strap that you can try out and make the gun fit your hand comfortably. Much improved over the USP, combine that with the reliability that a USP enjoys as well as HK's fit and finish and you have a great gun.

Sig has 3 handguns avaliable in .45acp that are not 1911's. The p220 series, p245, and p250. I would have to say I would take a CZ97b over anything on the list but since it wasn't included I'll have to go with the HK (I am just not a fan of striker fire actions).