Apply for a Grant

If you are a researcher investigating on Down syndrome and other intellectual disabilities from genetic origin appearing in early childhood, the Scientific Advisory Board of the Jerome Lejeune Foundation invites you to submit research projects on patients with Down syndrome (Research on Down syndrome should globally represent more than 50% of the overall annual amount) or more basic research on human chromosome 21; or research on patients with rare intellectual deficit from genetic origin.

The calls for proposals have been changed!!

•Autumn calls for proposals will be exclusively dedicated to Down syndrome research;

•Spring calls for proposals will be dedicated to both Down syndrome and other rare intellectual disabilities from genetic origin such as Fragile X, cri du chat, Rett, Williams-Beuren, Prader-Willi, Angelman, Smith-Magenis and other syndromes, will not exceed 50% of the total amount of the annual global grant. Autism not linked to above diseases is out of this call for grants.

Both calls applications could cover fundamental, translational, epidemiological, clinical research, neurobiology, and pharmacology including animal pharmacology, genetic, genomic, iPSCs, and neuropsychology techniques or data analysis. Priority will be given to clinical research projects.

Two types of research projects may be submitted and will be separately evaluated by the scientific board experts or external reviewers if needed for each call:

• Pilot or exploratory grants will be dedicated to initial early stage experiments built on preliminary data, or to ancillary projects to primary larger projects. The maximum funding will be 40,000.00 € for a maximum of two years (i.e. 20,000.00 € per year for a maximum of two years. The number of funded projects will depend of the annual global budget allocated by the Jerome Lejeune Foundation to the calls. Clinical projects could benefit from more funding.

• Advanced grants will be dedicated to larger breakthrough projects with preliminary data. The maximum funding will be 80,000.00 € for a maximum of two years (i.e. 40,000.00 € per year for a maximum of two years. Two to four projects could be funded per call.

• Through this call the Jerome Lejeune Foundation will also support the organization of conferences, workshops and courses. Such projects will also be reviewed by the Scientific Advisory Board.

For further details, please click on SAMPLE below.

PRACTICAL INFORMATION

Autumn call: please fill in the online application form “JLF Call for grants”from 18 June to 6 August 2018 end of business day.

• Dr. Sandra GuidiPrenatal treatment with a BDNF mimetic: a potential strategy for improving brain development in the Ts65Dn mouse model of Down syndromeUniversity of BolognaDepartment of Biomedical and Neuromotor Sciences (DIBINEM) Italy

• Dr. Fernando MoldenhauerStudy of the renin-angiotensin-aldosterone system and its relation to the absence of atherosclerosis in adults with Down syndromeFundación de Investigació Biomédica Hospital de La PrincesaUnidad de Atención a Adultos con Sindrome de Down (MIH-UPDOWN) Madrid, Spain

• Prof. Mary RutherfordSerial MRI to assess early structural and functional brain development in Down syndromeCentre for Developing Brain Department of Perinatal Imaging and HealthKings’ College London, United-Kingdom