MHC-Less cells - The present disclosure relates to compositions, methods, systems, computer-implemented methods, and computer program products thereof that relate to biological cells for delivery of at least one therapeutic agent to a biological tissue or subject.

01-26-2012

20120020938

MHC- less cells - The present disclosure relates to compositions, methods, systems, computer-implemented methods, and computer program products thereof that relate to biological cells for delivery of at least one therapeutic agent to a biological tissue or subject.

01-26-2012

20120020939

MHC-less cells - The present disclosure relates to compositions, methods, systems, computer-implemented methods, and computer program products thereof that relate to biological cells for delivery of at least one therapeutic agent to a biological tissue or subject.

01-26-2012

20120020949

MHC-LESS cells - The present disclosure relates to compositions, methods, systems, computer-implemented methods, and computer program products thereof that relate to biological cells for delivery of at least one therapeutic agent to a biological tissue or subject.

01-26-2012

20120020987

MHC-Less cells - The present disclosure relates to compositions, methods, systems, computer-implemented methods, and computer program products thereof that relate to biological cells for delivery of at least one therapeutic agent to a biological tissue or subject.

01-26-2012

20120022337

MHC-less cells - The present disclosure relates to compositions, methods, systems, computer-implemented methods, and computer program products thereof that relate to biological cells for delivery of at least one therapeutic agent to a biological tissue or subject.

Blood Pressure Cuff - A device can include a vibration sensor configured to sense blood flow in a lumen of a person; a cuff coupled to the vibration sensor and configured to contact a limb of the person; a mechanical cuff tensioner coupled to the cuff, the mechanical cuff tensioner configured to adjust a compressive force of the cuff on the lumen; a tension sensor operably coupled to the mechanical cuff tensioner, the tension sensor configured to measure a first tension value of the cuff during a first sense by the vibration sensor and to measure a second tension value of the cuff during a second sense by the vibration sensor; and a recorder mechanism configured to record the first tension value, the first measurement by the vibration sensor, the second tension value, and the second measurement by the vibration sensor.

09-19-2013

20130245391

Blood Pressure Cuff - A device may include a vibration sensor configured to sense blood flow in a lumen of a person; a cuff coupled to the vibration sensor and configured to contact a limb of the person; a cuff pressurizer coupled to the cuff, the cuff pressurizer configured to adjust a compressive force of the cuff on the lumen; and an energy-generating apparatus coupled to the cuff, the energy-generating apparatus configured to generate energy from a depressurization of the cuff.

09-19-2013

20130261372

Device, System, and Method for Delivery of Sugar Glass Stabilized Compositions - Devices, methods, and compositions are described that includes an implantable device including one or more compartments. One or more pharmaceutically effective compounds stabilized in a sugar glass composition, at least one of the one or more stabilized pharmaceutically effective compounds in the sugar glass composition enclosed within the one or more compartments; and one or more reservoirs configured to provide access for one or more release agents to an interior of the sugar glass composition, wherein the one or more reservoirs are configured to controllably dispense the one or more release agents to disrupt the sugar glass composition from the interior of the sugar glass composition.

10-03-2013

20130261593

Device, System, and Method for Delivery of Sugar Glass Stabilized Compositions - Devices, methods, and compositions are described that includes an implantable device including one or more compartments. One or more pharmaceutically effective compounds stabilized in a sugar glass composition, at least one of the one or more stabilized pharmaceutically effective compounds in the sugar glass composition enclosed within the one or more compartments; and one or more reservoirs configured to provide access for one or more release agents to an interior of the sugar glass composition, wherein the one or more reservoirs are configured to controllably dispense the one or more release agents to disrupt the sugar glass composition from the interior of the sugar glass composition.

10-03-2013

20140271579

Compositions, Methods, and Computer Systems Related to Making and Administering Modified T Cells - Embodiments described herein relate to methods, devices, and computer systems thereof for the derivation of T CAR libraries (Universal Subject or Individual Subject) for personalized treatment of disease in a subject. In certain embodiments, differential screening of normal and diseased tissue expression data is utilized to determine disease-specific antigens and thereby generate T CAR cells reactive to such antigens to form a disease-specific library. In certain embodiments, determination of the most effective T CAR clones from the disease-specific library is based on the subject's own disease-specific antigens. In certain embodiments, a subject is treated with a therapeutically effective amount of T CAR clones.

09-18-2014

20140271581

COMPOSITIONS, METHODS, AND COMPUTER SYSTEMS RELATED TO MAKING AND ADMINISTERING MODIFIED T CELLS - Embodiments described herein relate to methods, devices, and computer systems thereof for the derivation of T CAR libraries (Universal Subject or Individual Subject) for personalized treatment of disease in a subject. In certain embodiments, differential screening of normal and diseased tissue expression data is utilized to determine disease-specific antigens and thereby generate T CAR cells reactive to such antigens to form a disease-specific library. In certain embodiments, determination of the most effective T CAR clones from the disease-specific library is based on the subject's own disease-specific antigens. In certain embodiments, a subject is treated with a therapeutically effective amount of T CAR clones.

09-18-2014

20140274801

COMPOSITIONS, METHODS, AND COMPUTER SYSTEMS RELATED TO MAKING AND ADMINISTERING MODIFIED T CELLS - Embodiments described herein relate to methods, devices, and computer systems thereof for the derivation of T CAR libraries (Universal Subject or Individual Subject) for personalized treatment of disease in a subject. In certain embodiments, differential screening of normal and diseased tissue expression data is utilized to determine disease-specific antigens and thereby generate T CAR cells reactive to such antigens to form a disease-specific library. In certain embodiments, determination of the most effective T CAR clones from the disease-specific library is based on the subject's own disease-specific antigens. In certain embodiments, a subject is treated with a therapeutically effective amount of T CAR clones.

09-18-2014

20140323819

MULTI-PARAMETER TEST UNITS FOR INITIAL INDICATION OF MEDICAL SYMPTOMS - Disposable test units to assist medical personnel are described. In some embodiments, a test unit includes: a solid support; a cavity in the solid support; a reaction chamber internal to the solid support, including a plurality of biochemical reagents; a first internal channel in the solid support, connected at a first end to the cavity, connected at a second end to the reaction chamber; at least one pathogen detection region internal to the solid support; a second internal channel in the solid support, connected at a first end to the reaction chamber, connected at a second end to the at least one pathogen detection region; a temperature detector; and a persistent visible temperature indicator attached to the temperature detector.

10-30-2014

20150054930

SYSTEMS, METHODS, AND DEVICES FOR ASSESSING MICROBIOTA OF SKIN - Devices, systems, and methods for assessing microbiota of skin are described which include: a skin-covering material with an inner surface conforming in shape to a topography of a skin surface and including a microbe-capture region; an image-capture device to capture a least one image of the inner surface of the skin-covering material and to transform the captured at least one image into a digital output including information associated with at least one property and a spatial distribution of at least one type of microbe bound to the microbe-capture region; and a computing device including circuitry configured to receive the digital output from the image-capture device, compare the at least one property of the at least one type of microbe with a database of reference microbe properties, and generate a digital profile including the at least one property and the spatial distribution of the at least one type of microbe bound to the microbe-capture region of the skin-covering material.

02-26-2015

20150054944

SYSTEMS, METHODS, AND DEVICES FOR ASSESSING MICROBIOTA OF SKIN - Devices, systems, and methods for assessing microbiota of skin are described which include: a skin-covering material with an inner surface conforming in shape to a topography of a skin surface and including a plurality of specific microbe-binding elements; an image capture device to capture an image of the inner surface of the skin-covering material and to transform the image into a digital output including information associated with at least one property and a spatial distribution of at least one type of microbe bound to the specific microbe-binding elements; and a computing device including circuitry configured to receive the digital output from the image-capture device, compare the at least one property of the at least one type of microbe bound to the specific microbe-binding elements with a database of reference microbe properties, and generate a digital profile including the at least one property and the spatial distribution of the at least one type of microbe bound to the specific microbe-binding elements.

02-26-2015

20150054945

SYSTEMS, METHODS, AND DEVICES FOR ASSESSING MICROBIOTA OF SKIN - Devices, systems, and methods for assessing microbiota of skin are described, including: a skin-covering material including an inner surface and an outer surface, the inner surface substantially conforming to a topography of a skin surface of an individual and including a plurality of signal-generating complexes, one or more of the plurality of signal-generating complexes configured to emit one or more signals in response to at least one type of microbe; an image capture device to capture an image of the inner surface of the skin-covering material, the image including one or more signals emitted from the plurality of signal-generating complexes, and to transform the image into a digital output; and a computing device including circuitry configured to receive the digital output, compare the properties of the imaged one or more signals with a database of reference signal-generating complexes, and generate a digital spatial profile of microbes on the skin-covering material.

02-26-2015

20150057574

Selecting and Delivering Treatment Agents based on a Microbe Profile - Kits, devices, methods, and systems for assessing microbiota of a body surface and selecting treatment agents to apply to the body surface to modulate one or more types of microbes are described which include a kit including a plurality of treatment agents, a microbe sampling unit including a microbe-capture region, and an analyzer including a user interface, at least one sensor component, and a computing component with a processor and circuitry.

02-26-2015

20150057622

Systems, Methods, and Devices for Delivering Treatment to a Skin Surface - Systems, methods, and devices are described for delivering treatment to a skin surface of an individual based on a microbe profile, which include a skin-treatment delivery device including at least one treatment agent reservoir with at least one port with a controllable valve, at least one conduit, a location-capture component, a data storage component to store information associated with the microbe profile, and a computing component including a processor and circuitry to receive information associated with a measured feature of a location on the skin surface, correlate the received information associated with the measured feature of the location on the skin surface with the stored information associated with the microbe profile, select one or more treatment agents for application to the location on the skin surface from a database of treatment agents, and actuate the controllable valve of the at least one treatment agent reservoir to modulate release of the selected one or more treatment agents.

02-26-2015

20150057623

Systems, Methods, and Devices for Delivering Treatment to a Skin Surface - Systems, methods, and devices are described for delivering treatment to a skin surface of an individual based on a treatment map, which include a skin-treatment delivery device including at least one treatment agent reservoir with at least one port with a controllable valve, at least one conduit, a location-capture component, a data storage component to store information associated with the treatment map, and a computing component including a processor and circuitry to receive information associated with a measured feature of a location on the skin surface, correlate the received information associated with the measured feature of the location on the skin surface with the stored information associated with the treatment map to select one or more treatment agents for application to the location on the skin surface, and actuate the controllable valve of the at least one treatment agent reservoir to modulate release of the selected one or more treatment agents.

02-26-2015

20150057939

MODIFYING A COSMETIC PRODUCT BASED ON A MICROBE PROFILE - Systems and methods are described for modifying a cosmetic product based on a microbe profile including an ingredient-microbe interaction dataset including information associated with interactions between reference cosmetic ingredients and types of reference microbes; and a computing device including circuitry configured to receive information associated with the microbe profile of an individual, receive information associated with an ingredient list of the cosmetic product, compare the microbe profile of the individual and the ingredient list of the cosmetic product to the ingredient-microbe interaction dataset, identify an interaction between at least one cosmetic ingredient in the ingredient list of the cosmetic product and at least one of the one or more types of microbes in the microbe profile of the individual, recommend a modification to the ingredient list in response to an identified interaction, and report to a user the recommended modification.

02-26-2015

20150057940

MODIFYING A COSMETIC PRODUCT BASED ON A MICROBE PROFILE - Systems and methods are described for modifying a cosmetic product based on a microbe profile including an ingredient-microbe interaction dataset including information associated with interactions between reference cosmetic ingredients and types of reference microbes; and a computing device including circuitry configured to receive information associated with the microbe profile of an individual, receive information associated with an ingredient list of the cosmetic product, compare the microbe profile of the individual and the ingredient list of the cosmetic product to the ingredient-microbe interaction dataset, identify an interaction between at least one cosmetic ingredient in the ingredient list of the cosmetic product and at least one of the one or more types of microbes in the microbe profile of the individual, recommend a modification to the ingredient list in response to an identified interaction, and report to a user the recommended modification.

02-26-2015

20150058368

Systems and Methods for Generating a Treatment Map - Systems and methods are described for generating a treatment map based on a microbe profile, which include receiving a two-dimensional microbe profile of a skin surface of an individual, selecting one or more treatment agents from a database of treatment agents, generating the treatment map by mapping the selected one or more treatment agents to each of one or more corresponding locations on the two-dimensional microbe profile of the skin surface of the individual, and reporting the treatment map to a user.