This chapter will discuss none-invasive techniques that are widely used to study protein-protein interactions. As an example,
their application in exploring interactions between proteins involved in bacterial cell division will be evaluated. First,
bacterial morphology and cell division of the rod-shaped bacterium Escherichia coli will be introduced. Next, three bacterial
two-hybrid methods and three Förster resonance energy transfer detection methods that are frequently applied to detect interactions
between proteins will be described and discussed in detail. The chapter concludes with a discussion about the application
and results of the techniques when studying proteins involved in cell division.

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