SAN FRANCISCO — One person was killed and six others were injured Wednesday night in a massive four-alarm blaze that heavily damaged a building in the city’s Mission District.

The fire broke out around 6:50 p.m. at 22nd and Mission streets, according to firefighters. Flames engulfed several parts of the building’s top floor and roof, including a Popeyes Louisiana Kitchen.

The cause of the fire was still undetermined. Several people were displaced, and the American Red Cross has set up shop for those affected by the fire at San Francisco City College at 22nd and Bartlett streets, in room 109.

The large building that caught on fire held retail businesses on the first floor and offices and apartments on higher floors.

Fire officials said the person killed was an adult male, but he was not identified. The conditions of the six people injured was not immediately released. One firefigher was also evaluated at the scene.

Around 50 displaced residents gathered at an evacuation center set up at a City College building at 22nd and Valencia streets, American Red Cross spokesman Woody Baker-Cohn said.

“It’s certain nobody is going back in there, everybody there is displaced,” Baker-Cohn said of the damaged building.

In September, three people, including a firefighter, were hospitalized with smoke inhalation as a result of a five-alarm fire that destroyed a building on the same block. In March, another five-alarm fire destroyed a $227 million housing development still under construction in the Mission Bay neighborhood.

Check back for updates.

Bay City News Service contributed to this report. Contact Katie Nelson at 408-920-5006 and follow her at Twitter.com/katienelson210.