Published in:American Journal of TransplantationPublication date:2006-07-01

In renal transplant patients randomized to tacrolimus and mycophenolate versus tacrolimus and sirolimus, kidney loss in the tacrolimus/sirolimus group was significantly greater and GFR was worse, indicating a survival and function disadvantage in the tacrolimus/sirolimus treatment compared to tacrolimus/mycophenolate. See also editorial by Bruce Kaplan in this issue on page 1501.