How Do You Address Possible Red Flags On The Resume?

At a recent workshop, an attendee asked about what to do about her low GPA and her resume. For recent graduates and current students, the GPA is standard on a typical resume so it’s a question worth answering. But even for more experienced hires, where GPA matters less if at all, this question is still relevant because it speaks to what to do if you have any potential red flag on your resume that you feel obligated to disclosed (e.g., a gap in employment). How do you address possible red flags on the resume?