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This document presents the blueprint of renewed and revitalised commitment to gender and human rights mainstreaming within the National Multisectoral Strategic HIV and AIDS framework of 2009 to 2014. It is about moving from the rhetoric on gender, human rights and HIV and AIDS to operationalising gender mainstreaming in all the sectors. As such this handbook should be read together with the National Multisectoral Strategic Framework for HIV and AIDS. It addresses the interconnectedness of HIV and AIDS response and addresses gender inequalities. …