Harrisburg Supercharger to Wexford, PA

I'm making the trek from Philadelphia to Wexford, Pa. The nav is telling me that I need to make two stops, one in Harrisburg and one in Somerset. Has anyone made this trip? I would love to do a straight shot from Harrisburg to Wexford as we will be traveling late and I want a minimum number of stops.

I know there is a decent altitude change but wanted to hear if anyone had done this before or if it was too risky.