data suggest a physiological role for MNK1a-Ser (zeige SIGLEC1 Antikörper)(353) phosphorylation in regulation of the MNK1a kinase, which correlates with increased eIF4E (zeige EIF4E Antikörper) phosphorylation in vitro and in vivo.

Data show that interferon-gamma (zeige IFNG Antikörper) regulated the metabolism and mRNA translation of macrophages by targeting the kinases mTORC1 and MNK1/2, both of which converge on the selective regulator of translation initiation eukaryotic initiation factor-4E (eIF4E (zeige EIF4E Antikörper)).

MKNK1 Antigen-Profil

Beschreibung des Gens

This gene encodes a Ser/Thr protein kinase that interacts with, and is activated by ERK1 and p38 mitogen-activated protein kinases, and thus may play a role in the response to environmental stress and cytokines. This kinase may also regulate transcription by phosphorylating eIF4E via interaction with the C-terminal region of eIF4G. Alternatively spliced transcript variants have been noted for this gene.