Author

Jin, Zhichao

Yang, Ruojie

Du, Yu

Tiwari, Bhoopendra

Ganguly, Rakesh

Chi, Robin Yonggui

Date of Issue

2012

School

School of Physical and Mathematical Sciences

Abstract

The first chiral phosphine-catalyzed activation of acrylates for intramolecular formal [2 + 4] reactions with unsaturated imines is described. The catalytic reactions afford N-heterocycles with exceptionally high diastereo- and enantioselectivities. The [2 + 4] products are amenable for further transformations to useful molecules such as chiral piperidines and multicyclic structures.