Duetact

OVERDOSE

Pioglitazone

During controlled clinical trials, one case of overdose
with pioglitazone was reported. A male patient took 120 mg per day for four
days, then 180 mg per day for seven days. The patient denied any clinical
symptoms during this period.

In the event of overdosage, appropriate supportive
treatment should be initiated according to the patient's clinical signs and
symptoms.

Glimepiride

An overdosage of glimepiride, as with other
sulfonylureas, can produce severe hypoglycemia. Mild episodes of hypoglycemia
can be treated with oral glucose. Severe hypoglycemic reactions constitute
medical emergencies requiring immediate treatment. Severe hypoglycemia with
coma, seizure, or neurological impairment can be treated with glucagon or
intravenous glucose. Continued observation and additional carbohydrate intake
may be necessary because hypoglycemia may recur after apparent clinical
recovery [see WARNINGS AND PRECAUTIONS].