The Bills vs Patriots odds is a matchup of contenders and pretenders in the NFC East. While the Bills are hoping to be a factor, another subpar season is closer to their reality. As for the Patriots, they won 11 games last year without Tom Brady and with him back in the lineup, online betting cappers will expect him to pick apart the feeble Bills defense.

Bills vs Patriots odds: Patriots 10.5

WHAT: NFL betting

WHEN: Monday, September 14 – 7:00 PM ET

WHERE: Gillette Stadium – Foxboro, MA

PICK: Patriots -10.5

Bills vs Patriots odds maker breakdown: The Storyline
The Bills will unveil Terrell Owens and their new no-huddle offense for the first time in the regular season. Owens has been a non-factor in the preseason after succumbing to a toe injury so his impact could be decent, but not huge.

The Patriots are the Super Bowl favorites and all eyes will be on Brady, who missed all of last season with a knee injury. Their offense looks like it hasn’t skipped a beat and on Monday Night Football, we’ll get to see just how good they really are.

Betting Edge: Even

Bills vs Patriots odds maker breakdown: Offense
The Bills offense has been inconsistent through the preseason for a number of reasons. The offensive line has been brutal, which is – and likely will be – their biggest issue all season long. There is plenty of skill, though, which means the Bills will be capable when they get protection. Quarterback Trent Edwards is still a question mark. Few people are fully certain that he’s a franchise starter at the position. Keep in mind that running back Marshawn Lynch is suspended for this game.

For the Patriots, there are no issues. NFL betting fans know that with Brady, Randy Moss, Wes Welker and now Joey Galloway, New England is going to be putting up the points in bunches. The Bills defense isn’t much of a match for this unit and look for the Pats to score as much as they want.

Betting Edge: Patriots

Bills vs Patriots odds maker breakdown: Defense
The Bills defense is a work in progress and they have felt the ripple effects of the no-huddle offense. With the Bills offense spending less time on the field, the defense has had to get on the field more often. This is a unit that has some good, young parts but has failed to come together as a competent unit.

Meanwhile, the Patriots defense is the opposite. They are a veteran, coherent unit that had a foundation heading into the offseason and has now been supplemented with quality young parts. They run complex schemes, which always make it tough for a young quarterback like Edwards. Look for them to force a couple of turnovers as they win the battle along the line of scrimmage.

Betting Edge: Patriots

Bills vs Patriots odds maker breakdown: Special Teams
The Bills special teams is one area where they can get a boost. Whether it’s Roscoe Parrish, Terrence McGee or Leodis McKelvin returning, they are all near Pro Bowl caliber.

Betting Edge: Bills

Bills vs Patriots odds maker breakdown: Notable Injuries
Both teams are healthy heading into this game but keep in mind that the Bills will be without Lynch, who is beginning his three-game suspension.

Betting Edge: Patriots

Bills vs Patriots betting breakdown: Outlook and Pick
The Patriots are a big favorite in the sportsbook, but that’s going to be the norm all year long. They are much better than the Bills in every facet of this game and shouldn’t have an issue covering. The Bills are very weak on the line of scrimmage, which has to be a concern. A teaser might be a good idea as a backdoor cover by the Bills is always possible.

STAN’S PICK: Patriots -10.5

For more daily sports betting analysis, check out the betonline.com Betting Edge daily and for more on the Bills vs Patriots matchup, check out our stats center.

Stan Simmons first tasted football through the college game, but his football handicapping has strictly focused on the professional sport. Not many people devote as much time to the NFL as Simmons. For six days a week he works, labors and handicaps the sport, and on the seventh he rests as the games play out. Thoughts or questions?

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