Sestrin

Table of contents

TM1620 belongs (by sequence similarity) to carboxymuconolactone decarboxylase
(CMD) family (Pfam02627), CMD, EC:4.1.1.44 is involved in
protocatechuate catabolism. Some members of this family, such as...

Gene mlr4105 from Mesorhizobium loti translates into the putative antioxidant defense protein (NP_105057.1) that belongs to the CMD group (PF02627). ZP_01012034, annotated as alkylhydroperoxidase fam...

The gene Bxe_C0569 gene (PF02627) in Burkholderia xenovorans LB400 encodes for a putative carboxymuconolactone decarboxylase (CMD). The protein structure shows very high structure similarity to the P...

Gene TM1040_2465 from Silicibacter sp. codifies for the YP_614459 sequence that belongs to the CarboxyMuconolactone Decarboxylase, CMD, group (PF02627). It shows 90% identity with the alkylhydroperoxi...

Reut_A2532 gene translates into the YP_296737 sequence that belongs to the putative alkylhydroperoxidase AhpD core protein, characterized by the conserved motif C86--C89---H93 of the CarboxyMuconolact...

The Dgeo_1446 gene encodes the YP_604910.1 amino acid sequence which folds into a single domain 195 residues long protein showing the signature of the Carboxy-Mucono-lactone Decarboxylase (CMD) group ...

pascual (10 edits)

Summary

Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress, as well as mediate p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. Sestrin also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation. Distant homology to bacterial AhpD proteins, several of which were solved by JCSG, provides a structural template for sestrin. It also illustrates the conservation of DNA defence mechanisms between eukaryotes and bacteria.