The series: The Giants lead the series 9-6 but the Seahawks won the most recent meeting in 2011, 36-25, in New Jersey.

The early line: Seahawks by 7.

Key players: Quarterback Eli Manning is having one of his worst seasons, with 20 interceptions, tied with the Jets’ Geno Smith for most in the NFL. He threw two in Sunday’s disaster at San Diego that ended the Giants’ playoff hopes. WR Victor Cruz remains one of the top receivers in the game with 71 receptions, tied for 13th in the NFL. Safety Antrell Rolle is tied for second in the NFL with five interceptions and end Justin Tuck has 8.5 sacks to rank 18th. Tuck has six sacks in the past two games.

New York’s keys to success: One number best illustrates New York’s struggles this season — a minus-13 turnover differential that is third-worst in the NFL (Jets are minus-18 and Houston minus-14). The Giants had three turnovers Sunday and the Chargers scored touchdowns after the first two to take a 24-0 lead. Turnovers helped lead to the Giants’ 0-6 start to the season. They then won five of six as the defense allowed just 14 points per game. But they have lost their past two games. The Giants, long known for their powerful running attack, are one of the worst running teams in the NFL, ranking 26th at 88 yards per game. That has put additional pressure on Manning, whose current passer rating of 74.2 would be his worst for a season since 2007. New York’s struggles have led to speculation about the future of 67-year-old coach Tom Coughlin, who is 88-67 in 10 seasons with the Giants.