CrAT

– English only –

The purpose of the study is to investigate the ability of the muscle to activate mitochondria during exercise by monitoring a metabolite called phosphocreatine (PCr) through a non-invasive methodology known as Magnetic Resonance Spectroscopy (MRS). We will determine whether this mitochondrial activation event is associated with a protein expressed in muscle named CrAT and the ability of the muscle tissue to obtain oxygen from the circulation. This PCr metabolite, CrAT protein, and oxygen supply to skeletal muscle are important factors for understanding exercise tolerance and muscle fatigue.