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Learning About MPNs - PV, ET, PMF

Myeloproliferative neoplasms (MPNs) are a closely related group of hematological malignancies in which the bone marrow cells that produce the body's blood cells develop and function abnormally. The three main myeloproliferative neoplasms are Polycythemia Vera (PV), Essential Thrombocythemia (ET) and Primary Myelofibrosis (PMF).

The myeloproliferative neoplasms are progressive blood cancers that can strike anyone at any age, and for which there is no known cure. A gene marker, JAK2, was discovered in 2005. It is present in most PV patients and 50% of ET and PMF patients. A second gene marker, Calreticulin or CALR, was discovered in 2013. It is present in 23.5% of people with MF and ET.

Click here to learn more about PV, ET, and PMF, including symptoms, diagnosis, progression, prognosis, possible causes, available treatments and prevalence.