It will raise the threshold for entry for many small businesses. Either they are accountants themselves or they will need to hire the services of an accountant, just to track the multi-state sales tax liabilities.

Another option which will (IMO) get a boost from this is businesses like Amazon, Etsy and other national consignment sales stores. They will pay the taxes and they are already set up to do this, for a cut of the sales pie.

How long before we get the "Government Store" which will do all sales...

Prepping is a necessary mindset, particularly Before we reach a crisis...
PS: Just say No to social media.