Gene Detail

Gene Symbol

CD274

Synonyms

B7-H | B7H1 | hPD-L1 | PD-L1 | PDCD1L1 | PDCD1LG1 | PDL1

Gene Description

CD274, CD274 molecule, encodes for an immunomodulatory ligand (PD-L1), which once bound to its receptor, PD-1, results in inhibition of T-cell activation (PMID: 24551119). CD274 overexpression has been observed across multiple tumor types, which has been associated with CD274 amplification, specifically in Hodgkin's lymphoma (PMID: 20628145).