《LEWIN’S GENES XII》目录一览

Contents

前言

原文摘录:

Of the diverse ways to study the living world, molecular biology has
been most remarkable in the speed and breadth of its expansion.
New data are acquired daily, and new insights into well-studied
processes come on a scale measured in weeks or months rather
than years. It’s difficult to believe that the first complete organismal
genome sequence was obtained a little over 20 years ago. The
structure and function of genes and genomes and their associated
cellular processes are sometimes elegantly and deceptively simple
but frequently amazingly complex, and no single book can do
justice to the realities and diversities of natural genetic systems.

This book is aimed at advanced students in molecular genetics and
molecular biology. In order to provide the most current
understanding of the rapidly changing subjects in molecular biology,
we have enlisted leading scientists to provide revisions and content
updates in their individual fields of expertise. Their expert
knowledge has been incorporated throughout the text. Much of the
revision and reorganization of this edition follows that of the third
edition of Lewin’s Essential GENES, but there are many updates
and features that are new to this book. This edition follows a logical
flow of topics; in particular, discussion of chromatin organization
and nucleosome structure precedes the discussion of eukaryotic
transcription, because chromosome organization is critical to all
DNA transactions in the cell, and current research in the field of
transcriptional regulation is heavily biased toward the study of the
role of chromatin in this process. Many new figures are included in
this book, some reflecting new developments in the field,
particularly in the topics of chromatin structure and function,
epigenetics, and regulation by noncoding RNA and microRNAs in
eukaryotes.

This book is organized into four parts. Part I (Genes and
Chromosomes) comprises Chapters 1 through 8. Chapter 1
serves as an introduction to the structure and function of DNA and
contains basic coverage of DNA replication and gene expression.
Chapter 2 provides information on molecular laboratory
techniques. Chapter 3 introduces the interrupted structures of
eukaryotic genes, and Chapters 4 through 6 discuss genome
structure and evolution. Chapters 7 and 8 discuss the structure of
eukaryotic chromosomes.

Part II (DNA Replication, Repair, and Recombination) comprises
Chapters 9 through 16. Chapters 9 through 12 provide detailed
discussions of DNA replication in plasmids, viruses, and prokaryotic
and eukaryotic cells. Chapters 13 through 16 cover recombination
and its roles in DNA repair and the human immune system, with
Chapter 14 discussing DNA repair pathways in detail and Chapter
15 focusing on different types of transposable elements.

Part III (Transcription and Posttranscriptional Mechanisms)
includes Chapters 17 through 23. Chapters 17 and 18 provide
more in-depth coverage of bacterial and eukaryotic transcription.
Chapters 19 through 21 are concerned with RNA, discussing
messenger RNA, RNA stability and localization, RNA processing,
and the catalytic roles of RNA. Chapters 22 and 23 discuss
translation and the genetic code.

Part IV (Gene Regulation) comprises Chapters 24 through 30. In
Chapter 24, the regulation of bacterial gene expression via
operons is discussed. Chapter 25 covers the regulation of
expression of genes during phage development as they infect
bacterial cells. Chapters 26 through 28 cover eukaryotic gene
regulation, including epigenetic modifications. Finally, Chapters 29
and 30 cover RNA-based control of gene expression in prokaryotes
and eukaryotes.