Link Between Inflammation, Depression and Combining A Statin With A SSRI

Medscape (8/8, Brooks) reports that a study published in the August issue of the American Journal of Psychiatry, a publication of the American Psychiatric Association, “supports a link between inflammation and depression and the antidepressant potential of combining a statin with a selective serotonin reuptake inhibitor (SSRI).”

The 872,216-patient study revealed that patients “with depression who took both an SSRI and a statin were far less likely to contact a psychiatric hospital, both in general and for treatment of depression, than their peers who took an SSRI alone.” An accompanying editorial observes the findings warrant “further investigation of the antidepressant potential of the combined treatment in larger randomized trials.”