CaMKII Cre line L7

eagle-i ID

Resource Type

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CaMKII-Cre (line L7ag#13) mice were a kind gift from Dr. Ioannis Dragatsis (University of Tennessee). The construct was composed of the 8.5 kb 5' flanking calcium/calmodulin-dependent protein kinase II gene (<i>CaMKII-alpha</i>) promoter fragment, a short synthetic intron, a Cre recombinase gene containing a nuclear localization sequence, and a poly(A) addition sequence. Transgenic constructs were injected into CBA X C57BL/6J fertilized eggs and founders were crossed with C57BL/6J mice.
These mice express Cre recombinase, under the control of the <i>CaMKII-alpha</i> promoter, postnatally in excitatory forebrain neurons (cortex, striatum, amygdala, Hippocampal CA1, CA3, and DG). A moderate level of Cre was also detected in testis, similar to the amount of Cre in the cerebellum, at P30 and P120.