First post, seems only right it should be here, as I am an amp settings addict!!!!
Here is how I dial up my Blockletter 5150 for rehearsal...keep in mind I tweak for shows depending on venue etc.
ENJOY!

Here's a very saturated tone for a Mesa Dual rectifier 3channel head. Set the power switch to Spongy and use the tube rectifier.

It does seem over saturated but I used my EMG 81-7 equipped guitar and I find that they are a bit dry and sterile so that's why the gain is up there close to 3o'clock.

Even though this seems ultra saturated and maybe muddy, it is in fact very articulate because of the mids. I even sometimes use my Boss MT-2 (distortion 0, level a little less than half way) to push it over the edge and it sounds even more saturated but maintains a very articulate sound.

I use a Mesa 4x12 Recto cab. V30's.
Works great for most places, adjust carefully for different environments.
Run the tubes warmer, while keeping the gain low and the master high, with a strong pick attack will keep it rather big sounding whilst keeping clear from the low preamp gain.
Doing this also keeps the fizz low.

Savage 120 through an OS Mesa 4x12
I use a Maxon OD9, ISP Decimator, Boss NS-2, and Boss tuner. I sometimes run a Line 6 Echo Park and Boss Super Chorus in the loop but not much though. The type of tone im looking for is something like The End of Heartache album by Killswitch Engage, This Is Exile by Whitechapel and Jeff' Loomis' Zero Order Phase. Chunky and saggy, but tight, clear, and smooth.

The guitars i use are a Parker Fly Deluxe with stock pups, Alder-bodied Jackson Dinky with 18 volt modded EMG 85 in the bridge and 60 in the neck, and an Ibanez S7420FM with Dimarzio D-Activators.

Im also open as to what tubes i should equip the Savage with since imma change them soon.

FX Loop
-Allums Mod GE-7
(Adjust slightly to add back bass that was removed before the preamp with the MT-2)

-BBE Sonic Stomp
Lo: 6.5ish
Pro: 6.5ish

You need the post up for this to sound right. I think 2.75 ~ 3 is a sweet spot. It's way too loud so I attenuate with a THD Hotplate 4ohm. The cab is a Marshall 1960A, and my guitar is a RG7321 w/ Invader or Jackson KV-2 tuned to C-std. I'm also using a Boss NS-2 in the infamous x-configuration.