April 4, 1997
A Postdoctoral Research Associate position is currently available
in my laboratory to participate in NIH-funded studies on mechanisms of
locus control region function and erythroid-specific gene transcription.
Questions being investigated include - how is the human b-globin lcr shared
by multiple promoters on a chromosome, what are the requirements for
long-range gene activation by lcrs, and do the protein components of the
lcr form ordered nucleoprotein complexes?
A second project focuses on the biology and regulation of
hematopoietic regulatory proteins. One focus is on the TAL1 protein, an
erythroid-specific transcription factor and crucial regulator of mammalian
development. The regulatory regions of the TAL1 gene are disrupted by a
chromosomal deletion in patients with acute T-cell lymphocytic leukemia.
This deletion results in ectopic expression of TAL1 in T-cells, and thus
may be directly involved in leukemogenesis. One aim is to delineate the
cis-acting elements and trans-acting factors which drive TAL1 transcription
in erythroid and T-cells. A second aim focuses on identifying target genes
for TAL1.
Potential applicants should submit a brief description of research
interests, a curriculum vitae, and the names of three individuals for
recommendations to:
Emery H. Bresnick, Ph.D.
University of Wisconsin-Madison
Department of Pharmacology
387 Medical Science
1300 University Avenue
Madison, WI 53706
TEL. (608) 265-6446
E-Mail - ehbresni at facstaff.wisc.edu