TUSB21x has a patent-pending design which is agnostic to USB low-speed (LS) and full-speed (FS) signals. LS and FS signal characteristics are unaffected by the TUSB21x while HS signals are compensated.

Programmable signal AC boost and DC boost permits fine tuning device performance to optimize high-speed signals at the connector, this allows use in many different applications.

In addition, TUSB21x is compatible with the USB OTG and BC protocols. The TUSB214 provides BC1.2 CDP controller for applications in which USB host or hub do not have this support. The TUSB215 acts as charging downstream port (CDP) controller and handles the necessary handshakes with the downstream device.