Quantitation of estrogen receptor has been performed in cytosol prepared from 75 specimens of breast cancer tissue from patients who had not received hormonal therapy. The study was performed in order to compare an immunoassay (Abbott Laboratories, North Chicago, IL) with our currently used method for estrogen receptor analysis based on isoelectric focusing of (/sup 3/H)estradiol-receptor complex in polyacrylamide gels. Using linear regression analysis, a regression coefficient (slope) of 1.30 and a correlation coefficient of 0.75 were calculated. The differences in results between the two methods are probably partly explained by the fact that the ligand-based method only measures unoccupiedmore » receptor, whereas the immunoassay detects the total amount of receptor, resulting in generally slightly higher concentrations with the latter method. However, in five of 75 specimens the ligand-based method gave a considerably higher concentration of estrogen receptor. This was most probably explained by partial proteolysis resulting in the formation of receptor fragment(s), which was undetectable with the immunoassay but detectable with the ligand-based method. These observations underline the importance of careful handling of specimens during the whole immunoassay procedure.« less

In order to further develop understanding of the observable changes in sterane isomer ratios, Abbott et al. (1990) conducted a series of hydrous pyrolysis experiments on mineral-free vitrinite kerogen. Using a deuterated model compound, they found that direct chiral isomerization appears to be relatively unimportant. They derived a kinetic model comprising consecutive release and degradation processes for both isomers and, using a bi-exponential concentration-time function, they were able to determine Arrhenius parameters for four individual reactions. Abbott et al. (1990) claimed that these four reactions account for the change in sterane diastereomer ratios in hydrous pyrolysis experiments. Since it hasmore » been observed by a number of people that the so-called steraine isomerization is not a unidirectional reaction, an alternative reaction scheme would be most welcome. Although Abbott and coworkers do not claim that the published kinetic data hold true in the natural environments, the question arises as to whether the kinetic data obtained from these hydrous pyrolysis experiments are applicable to sedimentary processes which occur over geological time.« less

The anomalous moments of the {ital W} boson are calculated in the composite model of Abbott and Farhi. We find that the estimates obtained are 2 to 3 orders of magnitude larger than those due to radiative corrections in the standard model.

We use a simple model to estimate the contribution to g-2 for the muon in the composite model of Abbott and Farhi. Dimension-5 operators must be introduced to describe the effective coupling of the composite left-handed muon to its constituents. We find an interesting suppression, which operates in the region of low scalar preon mass, of the leading-order term for g-2. The contribution of compositeness to g-2 is thus smaller than might naively be expected and is within experimental limits.