dactinomycin

Oncology An antitumor antibiotic member of a class of drugs first isolated from Streptomyces, and used to treat Wilms' tumor, Ewing sarcoma, embryonal rhabdomyosarcoma, choriocarcinoma, seminoma, KS, lymphoma

dac·ti·no·my·cin

(dak'ti-nō-mī'sin)

An antineoplastic antibiotic produced by several species of Streptomyces (e.g., S. parvulus).

dactinomycin

A cytotoxic drug used to treat cancers mainly of children. Dactinomycin is an antibiotic derived from Streptomyces pavullus which causes breaks in DNA. This side effect renders it unsuitable as an antibacterial drug, but makes it useful as an anti-cancer drug. A brand name is Cosmegen Lyovac. There are other actinomycins in the group produced by Streptomyces chrysomallas .

dac·ti·no·my·cin

(dak'ti-nō-mī'sin)

An antineoplastic antibiotic produced by several species of Streptomyces (e.g., S. parvulus).

dactinomycin

an antibiotic of the actinomycin complex (actinomycin D), produced by several species of Streptomyces; used as an antineoplastic agent.

Preliminary results of the study indicate that actinomycin-D is not effective in preventing restenosis and patients treated with actinomycin-D eluting stents have an unacceptably high target lesion revascularization rate.

This collaboration, coupled with the rapid progress we have made on our internal PHARMA-LINK(TM) Drug Coated Stent Program utilizing Actinomycin-D, demonstrates our commitment to bring this promising therapy to patients as quickly as possible.

As we rapidly advance in the clinical evaluation phase in both the paclitaxel-coated stent provided through our agreement with Cook, and our internal PHARMA-LINK(TM) Drug Eluting Stent Program utilizing Actinomycin-D, we are well on our way toward providing our customers with the broadest and deepest drug-coated stent product line in the industry.

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