I get events from all of these (emails/chats/FB notifications/posts) that I want to monitor and sometimes respond to. This is becoming exhausting - I need to check five or more different sites just to clear my "incoming" box (G+ has notification inside Gmail, thank god).

Is there a website to manage these "incoming events"? I want one place where I can consume these events easily.

Features of these services must be supported, or it's not good - I should be able to Vote on Reddit/StackExchange, Like and tag on social networks, mark as unread from Google Reader.

Everything must be synched to the web - I have two desktop computers and one Android device, and I don't want to miss notifications or get double notifications because of sync problems between these devices.

Replying inline inside the application is required. I'd hate to have to jump into the different websites, I want to do all this interaction from inside the app.

Good UI/UX is a must - if the font is too small, layout is butt ugly, or it just has a bad UX, I won't like it and won't use it. Good keyboard shortcuts are also indispensable to help me manage this information quickly (Think Gmail/Google Reader shortcuts).

Good login mechanism with OpenID / Facebook - I don't want to remember yet another super secure password like my Gmail pass - but this site will have access to all my stuff, so I can't use my default easy pass. KeePass is no good because I'll be logging into this site a lot. So the conclusion is that it has to support either Facebook or Open ID login (and have a decent easy to use implementation of it).

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Have you looked at Nimble? I hesitate to suggest it as an answer as I don't think it does everything you want.
–
ChrisF♦Jan 18 '12 at 12:21

@ChrisF - Thanks, it's an interesting app (just subscribed to their blog). Not quite an answer yet though. I would guess this fully featured tool I describe does not yet exist, only steps towards that.
–
ripper234Jan 18 '12 at 12:35