For thousands of years shamanic cultures have worked with plant entheogens to activate psychic capabilities. These sacred archaic traditions have consistently used psychoactive compounds for the diagnosis and treatment of illness, prediction of future events, clairvoyance, communication with other intelligences, and the integrationof magic with reality. Harmine, the first psychoactive principle isolated from ayahuasca decoctions, was initially called “telepathine” by Zerda Bayon in 1912, because of its apparently psychical properties.