The three-part story begins as a mother in Miami Horatio (David Caruso) enters her daughter missing. A search in the Everglades makes a severed arm and leg. The arm appears to be the starting model, but not the leg. Trace this point toward Las Vegas. Langston (Laurence Fishburne) recognizes the tattoo there on the leg, which was also a lost girl looking for work as a model. Langston leaves for Miami for further investigation and may appoint two suspects. But there are many more people involved, which can not be overtaken.

Meanwhile in New York caused a truck accident. When police arrived, the driver disappeared. Mac (Gary Sinise) takes it to a barrel containing the body of a girl from the liver is cut. It also shows the truck a little prison house but the prisoner is also untraceable. Fingerprints in the mobile cell expression of a missing girl recently in Miami and some young women have disappeared. Langston continues on his quest in The Big Apple and encounters a nationwide transport for human? Vrachtjes?: A ruthless gang kidnaps young women in various states to exploit them as sex slaves or? Slaughter? and selling their organs. The girl from the truck is probably still alive because they live longer worth the gang. But her time is ticking away. The trail leads Langston back to Las Vegas?