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But perceptions of a rebound in growth since then were tempered by a fall in the May Chicago regional business activity index, into negative territory, and a sharp fall in the University of Michigan's consumer confidence index to 90.7 from 95.9 in April.

The market was also being cautious going into the weekend with no deal in sight in Greece's crunch bailout talks with official creditors.

"The consumer confidence and the Chicago PMI plunged a bit, and I think this is about Greece," said Peter Cardillo of Rockwell Global Capital.

"The fact that (IMF chief Christine) Lagarde yesterday indicated that there is the potential for Greece leaving the eurozone, that's on the mind on investors and ahead of the weekend, this is causing this decline." Market action focused on Intel and Altera after a media report said Intel's bid for its chip-making rival is still alive.

In April it was believed Altera rejected an offer reported as just above US$50 a share.

Altera shares surged 4.0 per cent to US$48.85, while Intel was up 1.5 per cent at US$34.51.

Speculation on that deal came after Thursday's announcement that telecommunications chip specialist Broadcom would be acquired by Singapore-based Avago Technologies for US$37 billion.

Otherwise losses came across the board, with Alibaba falling 1.8 per cent, and AB InBev and Novartis both falling 1.5 per cent.

Drug producer Merck bucked the trend with a 2.0 per cent gain, after it announced it would partner with Amgen in work on developing two cancer drugs. Amgen shares lost 0.7 per cent.

Bond prices rose. The yield on the 10-year US Treasury fell to 2.10 per cent from 2.13 per cent Thursday, while the 30-year dropped to 2.85 per cent from 2.89 per cent. Bond prices and yields move inversely.