20090029341 - Sample support and sample store, especially for the cryopreservation of biological samples: A sample support (100, 101, 102, . . . ), in particular for cryopreservation of biological samples, is described and includes: a holder part (10) with a sample receiving chamber (11), a retaining device (12, 13) on which a sample can be disposed, and support connecting elements (14, 15) which... Agent: Caesar, Rivise, Bernstein, Cohen & Pokotilow, Ltd.

20090029344 - Compositions and assays utilizing adp or phosphate for detecting protein modulators: Described herein are methods which identify candidate agents as binding to a protein or as a modulator of the binding characteristics or biological activity of a protein. Generally, the methods involve the use of ADP or phosphate. The assays can be used in a high throughput system to obviate the... Agent: Townsend And Townsend And Crew, LLP

20090029343 - Methods for isolation and analysis of sialylated and phosphorylated peptides: Changes in sialylation of cell surface or plasma proteins are often associated with various cancers and other disease conditions Provided are methods of detecting biomarkers of conditions associated with a change of sialylation status. Sialylated peptides are first isolated from biological and other samples by loading onto titanium dioxide (TiO2)... Agent: Budde, Schou & Ostenfeld, A/s

20090029346 - Detection of human papilloma virus: An assay for detecting HPV comprising treating the viral nucleic acid with an agent that modifies cytosine to form derivative viral nucleic acid, amplifying at least a part of the derivative viral nucleic acid to form an HPV-specific nucleic acid molecule, and looking for the presence of an HPV-specific nucleic... Agent: Knobbe Martens Olson & Bear LLP

20090029348 - Kit for detecting the antibody of hcv and its preparing method: A kit and its preparing method concerning dual-antigen sandwich method are used for detecting the antibody against HCV, and its detecting mode is ‘carrier-first antigen-antibody against HCV to be detected-second antigen-marker-distinguishable signal’. The kit ant its preparing method characterize in that the second antigen is the complex of a HCV... Agent: Marshall, Gerstein & Borun LLP

20090029352 - Method for detecting the presence of a nucleic acid in a sample: An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations, or modules, in which discrete aspects of the assay are performed on fluid samples contained in reaction receptacles. The analyzer includes stations for automatically preparing a specimen sample, incubating the sample at prescribed temperatures for prescribed periods, performing... Agent: Rothwell, Figg, Ernst & Manbeck, P.c.

20090029347 - Method for identifying multiple analytes using flow cytometry: The present disclosure is directed to a method of using antibodies attached to different types of microspheres against different antigens located within a biological sample. Optical and electronic particle detection may be used to separate the microspheres via flow cytometry, allowing the subsequent measurement of multiple analytes in a single... Agent: Lanier Ford Shaver & Payne P.c.

20090029349 - Novel applications of acridinium compounds and derivatives in homogeneous assays: Chemiluminescent acridinium compounds are used in homogeneous assays to determine the concentration of an analyte in a sample without strong acid or strong base treatment. The chemiluminescent acridinium compounds include acridinium esters with electron donating functional groups at the C2 and/or C7 position on the acridinium nucleus to inhibit pseudo-base... Agent: Siemens Corporation Intellectual Property Department

20090029355 - Abnormalities of phosphatase 2a (pp2a) for diagnosis and treatment of alzheimer's disease: This invention relates to methods of diagnosing Alzheimer's disease and methods of screening for compounds for the treatment or prevention of Alzheimer's disease. The methods are based upon newly discovered differences in protein phosphatase 2A (PP2A) function and related molecular events in Alzheimer's disease cells compared to control cells. In... Agent: Milbank, Tweed, Hadley & Mccloy LLP

20090029372 - Adam12 as a biomarker for bladder cancer: Particularly ADAM12 mRNA expression was significantly upregulated in bladder cancer, as determined by microarray analysis, and the level of ADAM12 mRNA correlated with disease stage. ADAM12 protein expression correlated with tumor stage and grade. ADAM12 was present in higher levels in the urine from bladder cancer patients than in urine... Agent: Knobbe Martens Olson & Bear LLP

20090029377 - Diagnosing fetal chromosomal aneuploidy using massively parallel genomic sequencing: Embodiments of this invention provide methods, systems, and apparatus for determining whether a fetal chromosomal aneuploidy exists from a biological sample obtained from a pregnant female. Nucleic acid molecules of the biological sample are sequenced, such that a fraction of the genome is sequenced. Respective amounts of a clinically-relevant chromosome... Agent: Townsend And Townsend And Crew, LLP

20090029359 - Diagnostic methods for early cancer detection: The present disclosure is directed to compositions and methods for detecting signs of telomere dysfunction as diagnostic indicators of metastatic disease. More particularly, diagnostic reagents and procedures are provided for analyzing samples to detect elevated expression of TRK2 protein or detect the presence of telomere fusions as an early diagnostic... Agent: Barnes & Thornburg LLP

20090029362 - Gene copy number profiling: The invention relates to copy number profile analysis. Specifically, copy number profile analysis is used to determine whether two or more separate tumors in a single individual are derived from a common source.... Agent: Myriad Genetics Inc. Intellecutal Property Department

20090029375 - Genetic models for stratification of cancer risk: The present invention provides new methods for the assessment of cancer risk in the general population. These methods utilize particular alleles of in multiple selected genes to identify individuals with increased or decreased risk of breast cancer. In addition, personal history measures such as age and family history are used... Agent: Fulbright & Jaworski L.l.p.

20090029376 - High fidelity restriction endonucleases: Compositions and methods are provided for enzymes with altered properties that involve a systematic approach to mutagenesis and a screening assay that permits selection of the desired proteins. Embodiments of the method are particularly suited for modifying specific properties of restriction endonucleases such as star activity. The compositions include restriction... Agent: Harriet M. Strimpel, D. Phil.

20090029378 - High sensitivity multiparameter method for rare event analysis in a biological sample: A sample of blood containing CTCs, or other cells of interest, is stained with fluorescent markers for image analysis and scanned to identify the presence and location within the cartridge of target cells or subcellular elements. A sample containing desired target cells or subcellular elements is then further processed, in... Agent: Philip S. Johnson Johnson & Johnson

20090029380 - Human muty: A human mutY polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for preventing and/or treating diseases associated with a mutation in this gene. Diagnostic assays for identifying mutations in nucleic acid... Agent: Myriad Genetics Inc. Intellecutal Property Department

20090029371 - Method for determining vasoreactivity: The present invention is generally directed to methods and materials for determining the genotype of a patient to predict the patient's vasoreactivity. More particularly, the present invention is directed to a method of determining the vasoreactivity of a subject, comprising: obtaining from a subject a sample comprising a nucleic acid... Agent: Brinks Hofer Gilson & Lione/utah Utah Office

20090029357 - Method for diagnosing cancer using cancer-associated deletion gene marker: It is an object of the present invention to provide a novel method for diagnosing cancer by discovering a cancer-associated gene which could not be detected by a conventional technique, and detecting deletion, mutation, or an abnormal expression level of such cancer-associated gene. The present invention provides a method for... Agent: Birch Stewart Kolasch & Birch

20090029373 - Method for the quantitative detection of nucleic acids: Provided herein is a method for the quantitative detection of HHV-6 subtypes A and/or B based on the use of a calibrator, suitable primers and probes, and a nucleic acid polymerase with 5′-3′ nuclease activity.... Agent: Nixon & Vanderhye, Pc

20090029381 - Methods and compositions for analyzing ahasl genes: The invention relates to methods and compositions for analyzing plant acetohydroxy acid synthase large subunit (AHASL) genes. In particular, the invention relates to methods for the detection of wild-type AHASL alleles and mutant AHASL alleles that encode imidazolinone-tolerant AHASL proteins. The methods involve the use of PCR amplification and novel... Agent: Alston & Bird LLP Basf Corporation

20090029358 - Methods and compositions for the diagnosis and treatment of schizophrenia: Compositions and methods relating to the diagnosis and treatment of neuropsychiatric disorders, such as schizophrenia, schizoaffective disorders, and bipolar disorders are disclosed. Also provided are methods for screening therapeutic agents having efficacy for the treatment of such disorders.... Agent: Dann, Dorfman, Herrell & Skillman

20090029353 - Molecular detector: Described herein are embodiments of a method and device comprising an electronic charge detector capable of detecting the presence of small quantities of electric charge generated through a universal signal generation process that is configured to detect any biological agents and biomolecular targets of interest. Electric charge results from signal... Agent: Paul Roath

20090029385 - Molecular redundant sequencing: Methods, systems and compositions where a target nucleic acid includes a registration sequence disposed therein for identification of the number or relative position of determined sequence from the template sequence. Particularly preferred aspects include a registration sequence in a circular template nucleic acid sequence which is, in turn, used in... Agent: Pacific Biosciences Of California, Inc.

20090029360 - Nucleic acid amplification and detection of mycobacterium species: Oligonucleotides used to prime in vitro nucleic acid amplification of 16S rRNA sequences or DNA encoding 16S rRNA sequences for many species within the genus Mycobacterium are disclosed. Kits including such oligonucleotides are disclosed. Methods of detecting Mycobacterium species using the oligonucleotides in in vitro nucleic acid amplification are disclosed.... Agent: Gen Probe Incorporated

20090029383 - Polynucleotide sequencing method: The subject invention pertains to a method for determining the sequence of a polynucleotide comprising the steps of (i) contacting a polynucleotide processive enzyme immobilised in a fixed position, with a target polynucleotide under conditions sufficient to induce enzyme activity; (ii) detecting an effect consequent on the interaction of the... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20090029370 - Real time nucleic acid detection in vivo using protein complementation: The present invention relates to a method to detect nucleic acid molecules, such as RNA molecules in vivo using real time protein complementation methods. The invention further relates to methods for detecting nucleic acids, for example RNA in real-time in living cells with a high sensitivity, using a novel split... Agent: Ronald I. Eisenstein

20090029364 - Specific multiplex analysis of nucleic acids: A method of detecting the presence or absence of variant nucleotides within target nucleic acid sequences, said method comprising the use of at least one pair of target-specific amplification primers capable of hybridizing to target nucleic acid sequences, and the use of at least one set of diagnostic primers, each... Agent: Jacobson Holman Pllc

20090029374 - System and method for identifying networks of ternary relationships in complex data systems: A system and method for identifying high order associations between variables in complex systems that is particularly useful where there is no correlation or weak correlation between variables due to the influence of a third variable, a ternary relationship. The ternary relationship describes how the variation in the pattern of... Agent: John P. O'banion O'banion & Ritchey LLP

20090029384 - Techniques for recording signals: The present invention provides techniques of recording signals. In one aspect of the invention, a method of recording a signal comprises the following steps. One or more errors are selectively introduced during synthesis of a polymer in response to the signal. The one or more occurrences of the one or... Agent: Ryan, Mason & Lewis, LLP

20090029388 - Detection of antibodies: The present invention relates to a method for detecting antibodies against a target antigen in a sample which comprises contacting the sample with labelled target antigen, subjecting the sample to immunoprecipitation to precipitate antibodies in the sample and detecting the presence of antibodies against the target antigen in the sample... Agent: Rothwell, Figg, Ernst & Manbeck, P.c.

20090029394 - Novel assay for the detection of an antibody bound to a cell membrane receptor: This invention relates to the design of a novel immunoassay specific for the measurement of humanized antibody, Campath-1H, bound to the CD52 cell membrane receptor. The method can be used for pharmacokinetic studies and for monitoring purposes. The invention reveals improvements in higher specificities and sensitivities that can be obtained... Agent: Birch Stewart Kolasch & Birch

20090029395 - Methods for detection of chlamydia in samples: This invention relates to assays for Chlamydia which include the step of inactivating lipid oxidation activity in a biological sample, such as a blood or serum sample. This inactivation improves the detection of Chlamydia antigens or anti-Chlamydia antibodies. Methods and materials for the detection of Chlamydia and Chlamydial infection are... Agent: Nixon & Vanderhye, Pc

20090029392 - Magnetic-nanoparticle conjugates and methods of use: The present invention provides novel compositions of binding moiety-nanoparticle conjugates, aggregates of these conjugates, and novel methods of using these conjugates, and aggregates. The nanoparticles in these conjugates can be magnetic metal oxides, either monodisperse or polydisperse. Binding moieties can be, e.g., oligonucleotides, polypeptides, or polysaccharides. Oligonucleotide sequences are linked... Agent: Fish & Richardson Pc

20090029396 - Assay kit and antibody for human low molecular weight cd14: The present invention provides an antibody prepared using a peptide as an antigen, the peptide having 8 to 30 amino acid residues selected from an amino acid sequence at positions 1 to 68 of human high-molecular-weight CD14, or an antibody that binds to a peptide having a specific amino acid... Agent: Birch Stewart Kolasch & Birch

20090029397 - Method for monitoring tocolytic treatment: A method of monitoring tocolytic therapy in a pregnant woman. The method comprises determining a first concentration of placental protein 13 (PP13) in a bodily substance of a woman who has not received treatment with a tocolytic agent, determining a second concentration of PP13 in a bodily substance of the... Agent: The Nath Law Group

20090029398 - Microbial atp extraction and detection system: The present invention is directed to compositions and methods for single-step extraction and detection of ATP levels from microbial cells. The disclosed compositions are formulated to efficiently elicit bioluminescent detection of ATP among a broad variety of different microorganisms using a common single-step reagent composition. Additional luminescence-based methods are provided... Agent: Brinks Hofer Gilson & Lione

20090029400 - Pharmaceuticals and methods for treating hypoxia and screening methods therefor: Light-generating fusion proteins having a ligand binding site and a light-generating polypeptide moiety and their use as diagnostics, in drug screening and discovery, and as therapeutics, are disclosed. The light-generating fusion protein has a feature where the bioluminescence of the polypeptide moiety changes upon binding of a ligand at the... Agent: Fibrogen, Inc. Legal - Ip

20090029401 - Method for detecting biofuel producing microbes: A method for detecting biofuel producing microbes in a colorimetric assay by providing a microbe, a feedstock, and an assay solution. The assay solution contains an alcohol oxidase, a peroxidase, and a peroxidase co-substrate. The microbe is cultured with the feedstock as part of a culture medium that produces a... Agent: Rockey, Depke & Lyons, Llc

20090029402 - Assessment of biological or chemical samples: A method for monitoring consumption or release of a gaseous analyte such as oxygen by a liquid sample under investigation includes providing a cuvette (1) having an elongate narrow tube (12) of a material which is substantially gas impermeable and which is at least partly transparent to measurement excitation radiation... Agent: Jacobson Holman Pllc

20090029403 - Sesnsor for detecting a toxic or hazardous gas mixture and operating method: A sensor for detecting a gas mixture which substantially comprises air and contains one or a plurality of gases that exhibit a disadvantageous effect on living organisms, comprising: a sensor chip composed of silicon for reading out at least one signal which is generated at a sensitive substance given the... Agent: Staas & Halsey LLP

20090029407 - Systems and methods for analyzing and manipulating biological samples: A system for qualifying cells of a cell sample labeled with a magnetic or magnetizable moiety is provided. The system includes a cell sample holder for holding a cell of the cells and a first cell analyzer which includes a magnetic field source for applying a magnetic field to the... Agent: Martin D. Moynihan Prtsi

20090029408 - Methods for characterizing cell proximity: One aspect of the invention relates to a method of identifying cell adjacency in a coculture of cells. The method includes generating a first set of image data of the coculture of cells, the first set of image data comprising nuclear position data for each imaged cell; generating a second... Agent: Choate, Hall & Stewart LLP/wyeth

20090029409 - Method for determination of oxidative stress: Provided is a biomarker that enables easy and rapid detection of oxidative stress on a living organism and enables prevention of tissue damage or cell necrosis by drug administration, and which is a powerful marker for the study of toxicity and pharmacokinetics of various agents. Oxidative stress is determined by... Agent: Clark & Elbing LLP

20090029410 - Lipases from thermophilic anaerobes: The inventors have identified polypeptides having lipase activity in anaerobic thermo-philic bacteria. Accordingly, the invention provides a process for hydrolyzing an ester bond in a substrate, which comprises treating the substrate with a particular lipase (a polypeptide having lipase activity). The invention also provides a lipase for use in the... Agent: Novozymes North America, Inc.

20090029414 - Cell-free synthesis of membrane bound polypeptides: Methods are provided for the utilization of bacterial cell-free extracts in the synthesis of high yields of membrane- associated polypeptides.... Agent: Stanford University Office Of Technology Licensing Bozicevic, Field & Francis LLP

20090029412 - Solubility tags for the expression and purification of bioactive peptides: Peptide tags, referred to here as inclusion body tags, are disclosed useful for the generation of insoluble fusion peptides. The fusion peptides comprise at least one inclusion body tag operably linked to a peptide of interest. Expression of the fusion peptide in a host cell results in a product that... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20090029416 - Hyperthermostable protease gene: There are provided hyperthermostable proteases having an amino acid sequences represented by SEQ ID Nos. 1, 3 and 5 of the Sequence Listing or functional equivalents thereof and hyperthermostable protease genes encoding those hyperthermostable protease. There is also disclosed a process for preparation of a hyperthermostable protease by culturing a... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20090029417 - Recombinant microorganism: The object of the invention is to provide a microorganism which enhances productivity of cellulase and is useful for industrial production of cellulase, and to provide a method for producing cellulase by use of the microorganism. The present invention provides a recombinant microorganism produced by transferring a gene encoding cellulase... Agent: Sterne, Kessler, Goldstein & Fox P.l.l.c.

20090029419 - Expression of modified antibodies in avian cells: The present invention relates to construct and methods which allow the expression of immunoglobulins or functional fragments thereof which have been altered to that they are humanised. The expression of the immunoglobulins or fragments thereof takes place in avian cells, and the constructs used have been altered such that the... Agent: Drinker Biddle & Reath Attn: Intellectual Property Group

20090029420 - Acid-resistant solubility tag for the expression and purification of bioactive peptides: An acid-resistant peptide solubility tag (an “inclusion body tag”) is provided that is effective in producing peptides of interest in an insoluble form. Fusion peptide constructs comprising the inclusion body tag fused to a peptide of interest are provided. An acid cleavable peptide moiety separates the inclusion body tag from... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20090029422 - Reactor plate and reaction processing method: The reactor plate preferably includes a sealed reactor, a reactor flow channel connected to the reactor, a sample container constituted from a sealed container provided separately from the reactor, a sample container flow channel to be connected to the sample container, a syringe for sending a liquid, a switching valve... Agent: Cheng Law Group, Pllc

20090029423 - Method for separating target component: A construct in which at least a part of the magnetic material is coated with a polyhydroxyalkanoate (PHA), and a method for producing a construct by immobilizing a PHA synthesizing enzyme on the surface of the magnetic material, thereby biosynthesizing and coating a PHA.... Agent: Fitzpatrick Cella Harper & Scinto

20090029424 - Recombinant enzyme with altered feedback sensitivity: The present invention relates to the use of recombinant homoserine transsuccinylase enzymes with altered feedback sensitivity (MetA*) and possibly recombinant S-adenosyl methionine synthetase enzymes with reduced activity (MetK*) for the production of methionine, its precursors or derivatives thereof.... Agent: Ip Group Of Dla Piper Us LLP

20090029425 - Process for the production of beta-lysine: Process for the production of -lysine by constructing a recombinant microorganism which has a deregulated lysine 2,3-aminomutase gene and at least one deregulated gene selected from the group (i) which consists of aspartokinase, aspartatesemialdehyde dehydrogenase, dihydrodipicolinate synthase, dihydrodipicolinate reductase, tetrahydrodipicolinate succinylase, succinyl-amino-ketopimelate transaminase, succinyl-diamino-pimelate desuccinylase, diaminopimelate epimerase, diamino-pimelate dehydrogenase, arginyl-tRNA... Agent: Connolly Bove Lodge & Hutz, LLP

20090029427 - Increased yield in gas-to-liquids processing via conversion of carbon dioxide to diesel via microalge: The present invention is generally directed to systems and methods for integrating gas-to-liquids (GTL) processing with biofuels production. In some embodiments of the present invention, carbon dioxide (CO2) generated by GTL processing is used to support grovel (via photosynthesis) of microalgae. In some such embodiments, the microalgae can be further... Agent: Chevron Services Company Law, Intellectual Property Group

20090029428 - Novel microorganism, lipid-modifying agent, and the method of manufacturing 2-acyl lysophospholipids: The present invention provides a new supply source of phospholipase A1, which is useful for phospholipid modification and lipid biochemical research, and offers a method capable of efficiently manufacturing a large amount of high DHA content phospholipids and lysophospholipids. A novel microorganism HFKI-0020 (FERM AP-20545) of the genus Pseudomonas which... Agent: Oliff & Berridge, Plc

20090029429 - Process for producing optically active 2-substituent-oxy-3-(4-substituent-oxyphenyl) propionic acid derivative: The present invention relates to a process for producing an optically active 2-substituent-oxy-3-(4-substituent-oxyphenyl)propionic acid derivative which comprises stereoselectively reducing an 2-oxo-3-(4-substituent-oxyphenyl)propionic acid by an enzyme and subjecting the thus-obtained optically active 2-hydroxy-3-(4-substituent-oxyphenyl)propionic acid to esterification of the carboxyl group according to need, then to alkylation of the hydroxyl group and,... Agent: Connolly Bove Lodge & Hutz LLP

20090029430 - Novel carbonyl reductase, gene therefor and use thereof: The present invention is to provide a process for efficiently producing an optically active alcohol including (R)-3-hydroxy-3-phenylpropanenitrile. One of the features of the present invention is a polypeptide having an activity of asymmetrically reducing 3-oxo-3-phenylpropanenitrile isolated from a microorganism belonging to the genus Candida to produce (R)-3-hydroxy-3-phenylpropanenitrile, DNA encoding the... Agent: Sughrue Mion, Pllc

20090029432 - Dry fractionation of corn: Novel grain processing methods and the products obtained therefrom are disclosed. Methods may include separation of pericarp fractions, hydrolysis of the pericarp fractions one or more time, and fractionation of the hydrolyzed pericarp fractions. Hydrolyzed pericarp fractions have applications including fermentation media, livestock feed, and fuel feedstocks.... Agent: Buchanan Ingersoll & Rooney Pc

20090029434 - Modular membrane supported bioreactor for conversion of syngas components to liquid products: A modular membrane supported bioreactor for anaerobic conversion of gas into liquid products including membrane module(s) having a plurality of hollow fibers packed across a cross sectional area of the membrane module in a direction transverse to the axis of the membrane module; a membrane vessel for retaining the membrane... Agent: Cardinal Law Group

20090029435 - Deactivation of linking moieties in antibody-enzyme conjugates: In some embodiments, the present invention pertains to a method for conjugating a first compound to a second compound wherein the conjugation involves an electrophilic moiety. The method comprises reacting the first compound with the second compound to form a conjugate. The improvement in embodiments of the present invention comprises... Agent: Dade Behring Inc. Legal Department

20090029436 - Substantially pure reverse transcriptases and methods of production thereof: The present invention provides substantially pure reverse transcriptases, which are preferably substantially free from contamination with nucleic acids. The invention also provides methods for the production of these enzymes, and kits comprising these enzymes which may be used in synthesizing, amplifying or sequencing nucleic acid molecules, including through the use... Agent: Invitrogen Corporation C/o Intellevate

20090029438 - Composite materials comprising supported porous gels: This invention relates to a composite material that comprises a support member that has a plurality of pores extending through the support member and, located in the pores of the support member, and filling the pores of the support member, a macroporous cross-linked gel. The invention also relates to a... Agent: Foley Hoag, LLP Patent Group, World Trade Center West

20090029437 - Novel glucose dehydrogenase and method for producing the dehydrogenase: A novel glucose dehydrogenase, which is an enzyme that has high substrate specificity, can be produced at a low cost, is not affected by oxygen dissolved in a measurement sample and, in particular, has superior thermal stability is obtained by culturing a microorganism belonging to the genus Burkhorderia and having... Agent: Knobbe Martens Olson & Bear LLP

20090029439 - Regeneration: The invention relates to the filed of regeneration of cells, self-renewal of (micro-organisms), and the vegetative propagation of plant parts such as plant tissues or organs.... Agent: Hoffmann & Baron, LLP

20090029440 - Lipase variants: The invention provides variant lipases, preferably, variants with reduced tendency to odor generation obtained by introducing mutations in one or more regions identified in a parent lipase.... Agent: Novozymes North America, Inc.

20090029441 - Bionanomaterials and their synthesis: The use of biomaterials, such as viruses and virus-like particles, to form nanostructures is generally disclosed. For instance, rod-like viruses can be used to form composite nanofibers that are fixed together in a head-to-tail assembly by a polymer. Also, 2-dimensional nanostructures formed from crosslinked viruses assembled in a single, film-like... Agent: Dority & Manning, P.a.

20090029442 - Estrogenic substance degradable microorganism and use thereof: A microorganism capable of degrading an estrogenic substance contained in wastewater and the like; a method for the simple and effective degradation of an estrogenic substance contained in domestic wastewater, wastewater discharged from a livestock farm, or the like by using the microorganism; and an apparatus for achieving the degradation... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.c.

20090029443 - Compositions and methods for enhanced bacterial exopolysaccharide production: The present invention provides nucleic acid sequences and variants thereof capable of modulating exopolysaccharide production in Sphingomonas, and provides methods of using such nucleic acid sequences to generate bacteria that hyper-produce exopolysaccharide in slime form.... Agent: Seed Intellectual Property Law Group Pllc

20090029444 - Novel recombinant anticoagulant proteins: Novel recombinant anticoagulation proteins, methods of their use and methods of their production are described. In particular, recombinant fusions of annexin V (ANV) and Kunitz protease inhibitors (KPI) that possess potent anticoagulant activity are provided. The fusions, abbreviated ANV:KPI, utilize ANV having high affinity for phosphatidyl-L-serine with various KPI's to... Agent: Sonnenschein Nath & Rosenthal LLP

20090029445 - Algae growth system for oil production: A biological growth reactor vessel for the cultivation of micro-algae, diatoms or other unicellular organisms, especially for oil production, is described which incorporates a dispensing rod to which are attached a plurality of clear paddles which increase surface area for the diffusion of light and growth enhancing admixtures such as... Agent: Wesley B. Ames

20090029448 - Compost heat recovery system and method: In a composting system for outdoor operation for large-scale composting of municipal and other wastes, one or more large compost piles or windrows are supported on a pad, and covered with a removable cover. Fluid circulation pipes are embedded within the pad, to recover heat generated by aerobic decomposition of... Agent: The Webb Law Firm, P.c.

20090029446 - Integrated process for conversion of hydrocarbonaceous assets and photobiofuels production: The present invention is generally directed to processes that integrate CO2-producing conversions of hydrocarbonaceous assets with biofuels processes that utilize CO2 in photosynthesis. In some embodiments, such processes involve the absorption of CO2 in an absorption liquid. In some such embodiments, such absorption is carried out in an absorption tower.... Agent: Chevron Services Company Law, Intellectual Property Group

20090029447 - Process for removing mercury from air or water: The present invention provides for the removal of mercury utilizing Mer proteins. After the Mer proteins have been expressed and isolated, or alternatively using the native Mer protein complex, either can be used as a chelating agent to remove mercury from any aqueous mercury containing environment. The Mer protein may... Agent: West Virginia University Research Corporation

20090029450 - Incubator: An accommodating unit capable of accommodating a culture vessel, a transfer unit supporting and transferring the culture vessel, and taking in and out the culture vessel relative to the accommodating unit, and an observation unit observing a sample inside of the culture vessel via an observation optical system under a... Agent: Oliff & Berridge, Plc

20090029451 - Sterilization challenge specimen holder: A sterilization challenge specimen holder is used with a test indicator to challenge sterilization on a consistent basis. The holder includes a body having an internal chamber region. A cap is sealable on the holder. A plug is positioned in the body. The plug has a wall having a spiral... Agent: Levenfeld Pearlstein, Llc Intellectual Property Department

20090029452 - Apparatus and method for analyte detection: Disclosed is a testing device and methods for the identification of an analyte of interest in a sample. In a preferred embodiment, the testing device includes a front panel having at least one sample application aperture; a rear panel having at least one solvent application aperture; a sample collection matrix... Agent: Foley & Lardner LLP

20090029453 - Devices for the detection of multiple analytes in a sample: The present invention relates generally to an assay for detecting and differentiating multiple analytes, if present, in a single fluid sample, including devices and methods therefore.... Agent: Morrison & Foerster LLP

20090029454 - Sample block apparatus and method for maintaining a microcard on a sample block: A thermal cycling device for thermally cycling samples of biological material contained in a microcard having a top and bottom surface. The thermal cycling device can include a sample block having an upper surface configured for engaging the bottom surface of a microcard, a vacuum device, and a temperature control... Agent: Harness, Dickey & Pierce, P.L.C

20090029457 - Pharmaceutical composition for inducing an immune response in a human or animal: The present invention relates to a pharmaceutical composition for inducing an immune response in a human or animal, comprising dendritic cells loaded with at least five cancer/testis antigen and no lineage specific differentiation antigens or substantially no lineage specific differentiation antigens provided from at least one cancer cell line, as... Agent: Birch Stewart Kolasch & Birch

20090029456 - Str50 and uses thereof: The present invention relates to use of a novel gene, STR50 and to STR50 modulators in diagnostic, therapeutic and screening aspects related to neurotoxic events. More particularly, the present invention concerns diagnosing and treating neurodegenerative diseases, and screening for species which can be useful in treating the same.... Agent: Cooper & Dunham, LLP

20090029458 - Chicken leukemia inhibitory factor (lif) and gene thereof: The present invention is to provide a chicken LIF gene. Based on this genetic information, LIF protein derived from the chicken can be stably supplied and it solves the problems of the creation of transgenic chickens in the past. In addition, the present invention provides not only transgenic chickens for... Agent: Rader Fishman & Grauer Pllc

20090029460 - Neoplasm-specific polypeptides and their uses: The present invention features novel polypeptides and methods of using these polypeptides in the diagnosis detection, monitoring, and treatment of neoplasms in mammal, e.g., a human.... Agent: Clark & Elbing LLP

20090029461 - Immortalised feeder cells: The invention relates to an immortalized feeder cell line. The immortalized feeder cell line may be derived from an embryonic fibroblast, which may be a mouse embryonic fibroblast. A culture of an immortalized feeder cell line according to the invention in a suitable culture medium is also provided, as is... Agent: The Firm Of Hueschen And Sage

20090029462 - Automated method and apparatus for embryonic stem cell culture: The invention concerns methods for automated culture of embryonic stem cells (ESCs) such as human ESCs. In some aspects, methods of the invention employ optimized culture media and limited proteolytic treatment of cells to separate cell clusters for expansion. Automated systems for passage and expansion of ESCs are also provided.... Agent: Fulbright & Jaworski L.l.p.

20090029465 - Culturing human embryonic stem cells: Previous methods for culturing human embryonic stem cells have required either fibroblast feeder cells or a medium which has been exposed to fibroblast feeder cells in order to maintain the stem cells in an undifferentiated state. It has now been found that if high levels of fibroblast growth factor are... Agent: Quarles & Brady LLP

20090029464 - Feeder independent extended culture of embryonic stem cells: Previous methods for culturing human embryonic stem cells have required either fibroblast feeder cells or a medium which has been exposed to fibroblast feeder cells in order to maintain the stem cells in an undifferentiated state. It has now been found that if an antagonist of bone morphogenic protein is... Agent: Quarles & Brady LLP

20090029467 - Method for targeting lysosomal enzymes: Targeted therapeutics that localize to a specific subcellular compartment such as the lysosome are provided. The targeted therapeutics include a therapeutic agent and a targeting moiety that binds a receptor on an exterior surface of the cell, permitting proper subcellular localization of the targeted therapeutic upon internalization of the receptor.... Agent: Choate, Hall & Stewart LLP

20090029468 - Zinc finger binding domains for cnn: Polypeptides that contain zinc finger-nucleotide binding regions that bind to nucleotide sequences of the formula CNN are provided. Compositions containing a plurality of polypeptides, polynucleotides that encode such polypeptides and methods of regulating gene expression with such polypeptides, compositions and polynucleotide's are also provided.... Agent: Schwegman, Lundberg & Woessner, P.a.

20090029469 - Method for in vitro proliferation of dendritic cell precursors and their use to produce immunogens: A method for producing proliferating cultures of dendritic cell precursors is provided. Also provided is a method for producing mature dendritic cells in culture from the proliferating dendritic cell precursors. The cultures of mature dendritic cells provide an effective means of producing novel T cell dependent antigens comprised of dendritic... Agent: Merix Bioscience, Inc.

20090029470 - Process and culturing unit for culturing biological cells: A targeted cultivation phase adjustment is provided in a process for the cultivation of cells in which biological cells are cultivated on at least one boundary surface between different, non-solid cultivation phases so that pre-determined cultivation conditions are given. A cultivation apparatus (100) for biological cells is also provided that... Agent: Caesar, Rivise, Bernstein, Cohen & Pokotilow, Ltd.

20090023127 - Tissue system and methods of use: Apparatus and methods of use of a tissue system for culture and perfusion. The apparatus comprises a needle for injecting a fluid into the tissue.... Agent: Intellectual Property / Technology Law

20090023130 - Prevention of transfusion related acute lung injury using riboflavin and light: This invention is directed toward a method of preventing the formation of bioactive substances in a pathogen inactivated blood component. The steps include illuminating the blood component with light at a sufficient energy so that an alloxazine photosensitizer present in the blood component may be photolyzed to inactivate any pathogens... Agent: Caridianbct, Inc. Mail Stop: 810 1f2

20090023147 - Diagnostics and therapeutics for osteoporosis: Diagnostics and therapeutics for osteoporosis, which are bases upon the identification of a subjects IL-1 haplotype and genotype pattern are described.... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.c

20090023150 - Dna diagnostics based on mass spectrometry: Fast and highly accurate mass spectrometry-based processes for detecting a particular nucleic acid sequence in a biological sample are provided. Depending on the sequence to be detected, the processes can be used, for example, to diagnose a genetic disease or chromosomal abnormality; a predisposition to a disease or condition, infection... Agent: Grant Anderson LLP C/o Portfolioip

20090023137 - Esr1 and cervical cancer: The present invention provides methods and kits for detecting susceptibility to, or the incidence of, cervical cancer in a sample comprising determining the methylation status of the ESR1 gene, optionally as part of a panel of genes. Also provided are methods and kits which involve determining the expression levels of... Agent: Foley And Lardner LLP Suite 500

20090023144 - Method and its kit for quantitatively detecting specific analyte with single capturing agent: The invention provides a method and its kit for quantitatively detecting a specific analyte with a single capturing agent. The quantitative detection of a specific analyte with a single capturing agent comprises: firstly combining the tested analyte with a solid phase capturing agent, then labeling analyte which has been trapped... Agent: Schmeiser, Olsen & Watts

20090023141 - Method for detecting bacteria of the genus mycobacterium (acid-fast bacteria) and kit for the same: An object of the present invention is to provide an oligonucleotide for rapidly and conveniently detecting bacteria of the genus Mycobacterium (acid-fast bacteria) or for identifying the bacterial species thereof, and a method and kit for detecting bacteria of the genus Mycobacterium (acid-fast bacteria) using such oligonucleotid. The present invention... Agent: Birch Stewart Kolasch & Birch

20090023151 - Method for the labeling and detection of small polynucleotides: Methods and kits for use in isolating, labeling or detecting a small polynucleotide of interest from a sample. The method entails hybridizing the small polynucleotide to a capture probe, lengthening the small polynucleotide by primer extension and/or ligation, and degrading the capture probe to provide a single stranded extension product.... Agent: Sheldon Mak Rose & Anderson Pc

20090023142 - Methods for detecting minimum residual disease: The present invention features methods and compositions for identifying markers of minimum residual disease (MRD), as well as markers of metastatic cells. The present invention further provides methods for detecting MRD and metastatic cell in a subject.... Agent: Edwards Angell Palmer & Dodge, LLP

20090023134 - Neoplasia diagnostic compositions and methods of use: The invention generally features compositions and methods for the diagnosis and monitoring of a neoplasia (e.g., a prostatic neoplasia) in a subject, as well as methods of treatment selection.... Agent: Edwards Angell Palmer & Dodge LLP

20090023138 - Oral cancer markers and their detection: Methods of detecting progression from precancer to cancer are provided utilizing toluidine blue staining as well as detecting allelic variation at microsatellite loci. An allelic variation in one or more locus is indicative of a progression from precancer to cancer.... Agent: Jeffer, Mangels, Butler & Marmaro, LLP

20090023143 - Predicting agent for metastasis: By disclosing part of metastasis mechanisms in cancer cells, the metastatic potential of cancer cells will be determinable. Anti-galectin-9 Ab against galectin-9 is contained as an effective component with or without others, thereby enabling the evaluation or detection of galectin-9 expression levels in cancer cells wherein the metastatic potential of... Agent: Wenderoth, Lind & Ponack, L.l.p.

20090023154 - Relating to marking: The invention provides a marking system, markers and methods of use of such marking systems and markers which enable unique marking of articles and subsequent detection of that marking. In particular the invention provides a marking system, the marking system comprising a plurality of different DNA fragment types, each of... Agent: Merchant & Gould Pc

20090023148 - Sensors for biomolecular detection and cell classification: A sensor device is provided for detecting an analyte in a sample in which an analyte is bound to a detection reagent to form a bound complex. The device comprises (a) a sample (5) comprising an ionic analyte and a detection reagent in a conductive fluid, wherein the detection reagent... Agent: Richard R. Muccino

20090023153 - Targeted modification of chromatin structure: Methods and compositions for targeted modification of chromatin structure, within a region of interest in cellular chromatin, are provided. Such methods and compositions are useful for facilitating processes such as, for example, transcription and recombination, that require access of exogenous molecules to chromosomal DNA sequences.... Agent: Robins & Pasternak

20090023156 - Methods and reagents for quantifying analytes: The present invention relates to methods and reagents for quantifying analytes. More specifically, the present invention related to methods and reagents for measuring one or more analytes present in a sample.... Agent: Morgan, Lewis & Bockius, LLP.

20090023155 - Polyelectrolyte multilayer films at liquid-liquid interfaces and methods for providing and using same: The present invention is directed to methods for providing a polyelectrolyte multilayer film at a liquid-liquid interface. Such methods include steps of sequentially-depositing layers of cationic and anionic polyelectrolytes at a liquid-liquid interface that is formed between immiscible first and second liquids whereby a polyelectrolyte multilayer film is provided at... Agent: Quarles & Brady LLP

20090023157 - Proteome epitope tags and methods of use thereof in protein modification analysis: Disclosed are methods for reliably detecting the presence of proteins, especially proteins with various post-translational modifications (phosphorylation, glycosylation, methylation, acetylation, etc.) in a sample by the use of one or more capture agents that recognize and interact with recognition sequences uniquely characteristic of a set of proteins (Proteome Epitope Tags,... Agent: Goodwin Procter LLP Patent Administrator

20090023159 - Method for the in vitro diagnosis of alzheimer's disease using a monoclonal antibody: The invention relates to a method for the in vitro diagnosis of Alzheimer's disease using a monoclonal antibody. Said antibody can bind at least to amino acids 12-16 of the β-amyloid peptide, specifically detecting the neuritic plaques which are characteristic of Alzheimer's disease, without detecting diffuse plaques which are not... Agent: Ladas & Parry LLP

20090023160 - Antibodies specific for cyp1b1: Antibodies that can specially bind to cytochrome P450 CYP1B1 and methods of making them are disclosed, in particular antibodies that bind to amino acid sequence VNQWSVNHDPVKWPN or PExFDPARFLDKDGy, where x is D or N and y is L or F, or an antigenic fragment thereof. The antibodies can be used... Agent: Quine Intellectual Property Law Group, P.c.

20090023162 - Method for the identification of atypical p-anca: The invention relates to a method for the identification of atypical p-ANCA, kits suitable for the same and application of said method to the diagnosis of chronic inflammatory intestinal diseases and autoimmune liver diseases.... Agent: Joyce Von Natzmer Pequignot + Myers Llc

20090023163 - Method of measuring enzyme activity and method of evaluating compound: It is intended to provide a method of measuring an activity, which is a method of measuring an activity of an enzymatic reaction in which a lipid-soluble reaction product is formed by catalyzing an addition reaction of two or more kinds of substrates, characterized by comprising a labeling step in... Agent: Merck And Co., Inc

20090023164 - Compositions and methods for the detection of hiv-1/hiv-2 infection: This invention relates to compositions and methods or the detection of immunodeficiency virus infection, especially immunodeficiency virus-1 (HIV-1) infection. The invention particularly concerns compositions and methods that may be used in HIV vaccine recipients whose sera may contain vaccine-generated anti-HIV-1 antibodies.... Agent: Woodcock Washburn LLP

20090023167 - Method, reagent and kit for determination of cholesterol in remnant-like particles (rlp): The present invention provides a method, a reagent and a kit for simple and sensitive determination of cholesterol in remnant-like particles without separation of components of a sample. A method for quantitatively determining remnant-like particle cholesterol in a sample, which comprises: in an aqueous medium containing the sample and in... Agent: Fitzpatrick Cella Harper & Scinto

20090023169 - High throughput sarcomeric assay: The present invention provides high throughput screening systems for identifying compounds that modulate the biological activity of a biochemically functional sarcomere. The method can be performed in plurality simultaneously with fluorescence or absorbance readouts.... Agent: Townsend And Townsend And Crew, LLP

20090023172 - Gtp cyclohydrolase ii as a target for fungicides: The present invention relates to the identification of fungal GTP cyclohydrolase II as a target for fungicides, to a method for identifying antifungal agents based on fungal GTP cyclohydrolase II, and also to the use of compounds identified as fungicides via the abovementioned method.... Agent: Brinks, Hofer, Gilson & Lione

20090023171 - Method for determining specific groups constituting heparins or low molecular weight heparins: The invention provides methods for analysing heparins, low-molecular-weight heparins, ultralow-molecular-weight heparins, and oligosaccharides by high performance liquid chromatography a stationary phase dynamically coated with a quaternary ammonium salt. The methods of the invention may be used to analyse samples without pre-treatment or to analyse samples that have been partially or... Agent: Sanofi - Aventis / Finnegan Henderson LLP

20090023170 - Methods and kits for the detection of biotoxic and antibiotic residues: The invention provides a kit for the detection of antibiotic residues comprising inducible bacterial spores which produce an induced enzyme after germination and induction; a germinant that triggers rapid germination of said spores; an inducer that triggers the production of the specific enzyme of interest; a substrate upon which said... Agent: Baker Botts LLP C/o Intellectual Property Department

20090023175 - Device for sampling a fluid and detecting an analyte therein: Provided is a device for detecting an analyte in a fluid comprising a first compartment (1) having an open end (1.2) and a closed end (1.1) wherein said closed end holds a medium (1.3) comprising a substance with which said analyte can be detected and a second compartment (2) having... Agent: Nixon & Vanderhye, Pc

20090023178 - Parkin substrate and assay: The invention provides in vitro, ex vivo, and in vivo assays for Parkin activity, in which Parkin-mediated ubiquitination of a Sept4 protein is measured. The assays may be used to screen for agents that modulate Parkin protein ligase activity.... Agent: Townsend And Townsend And Crew, LLP

20090023180 - Reduction of shading in microalgae: Methods provided herein are directed to increasing the efficiency of light utilization of photosynthetic microorganisms. Also provided are screening assays, genetic constructs, and photosynthetic microorganisms for increasing light utilization efficiency and production of molecules such as ATP, oxygen, hydrogen, and recombinant proteins. Methods provided herein can be performed with any... Agent: Beyer Weaver LLP

20090023181 - Method and device for detection of erythromycin-induced clindamycin resistance: A device and method are provided for determination of erythromycin-induced clindamycin resistance. The device is preferably a test panel containing one or more wells each having a known concentration(s) of erythromycin and known concentration(s) of clindamycin. After inoculation of the wells with a sample and incubation, the wells are analyzed... Agent: Dade Behring Inc. Legal Department

20090023182 - Complementary metabolizing organisms and methods of making same: The invention provides a non-naturally occurring set of microbial organisms. The set of organisms includes: at least a first constituent complementary metabolizing organism (CMO) exhibiting the ability to metabolize a first carbon substrate and having substantially impaired metabolic capacity for a second carbon substrate, and at least a second constituent... Agent: Mcdermott, Will & Emery

20090023185 - Avidin mutants: Two circularly permuted avidin monomers are designed. The circularly permuted monomers (cpAvd5→4 and cpAvd6→5) are fused and the resulting fusion peptides (dcAvd) form a pseudo-tetrameric dual-chain avidin, which is biologically active in biotin binding and shows similar structural characteristics as wild-type avidin. The dcAvd makes the development of dual-affinity avidins... Agent: Young & Thompson

20090023186 - Use of valproic acid for enhancing production of recombinant proteins in mammalian cells: Culturing cells for the commercial production of proteins for diagnosis and therapy is a costly and time consuming process. The equipment required is expensive, and production cost are high. In order to provide commercially viable processes it is desirable to use cell lines which produce large quantities of product with... Agent: Markus Hildinger

20090023187 - Method of obtaining a product sugar stream from cellulosic biomass: A process for obtaining a product sugar stream from cellulosic biomass is disclosed. In one process, the cellulosic biomass is pretreated at a pH between about 0.4 to 2.0 by adding one or more than one acid to produce a pretreated cellulosic biomass comprising acetic acid. One or more than... Agent: Fitzpatrick Cella Harper & Scinto

20090023188 - Heparin/heparosan synthase from p. multocida and methods of making and using same: The presently claimed and disclosed invention relates, in general, to dual action heparin synthases and, more particularly, to dual action heparin synthases obtained from Pasteurella multocida. The presently claimed and disclosed invention also relates to heparosan, heparin and heparin-like molecules provided by recombinant techniques and methods of using such molecules... Agent: Dunlap Codding, P.c.

20090023189 - Apparatus and methods for preparation of subtantially uniform emulsions containing a particle: Methods and systems for forming water-in-oil emulsions are described. For example, an apparatus is described which includes: a first compartment containing a plurality of particles dispersed in an aqueous phase; a second compartment containing an oil phase; a porous layer separating the first and second compartments; and a device for... Agent: Mila Kasan, Patent Dept. Applied Biosystems

20090023190 - Sequence amplification with loopable primers: The present disclosure relates to the amplification of target nucleic acid sequences. This can be accomplished via the use of various primers. The use of these primers, as described herein, results in nucleic acid structures that can reduce the amplification of nonspecific hybridization events (such as primer dimerization) while allowing... Agent: Knobbe Martens Olson & Bear LLP

20090023191 - Gene rcs 23: The present invention relates to newly identified genes that encode proteins that are involved in the synthesis of L-ascorbic acid (hereinafter also referred to as Vitamin C). The invention also features polynucleotides comprising the full-length polynucleotide sequences of the novel genes and fragments thereof, the novel polypeptides encoded by the... Agent: Nixon & Vanderhye, Pc

20090023192 - Process for producing ethanol: A process for producing ethanol including a combination of biochemical and synthetic conversions results in high yield ethanol production with concurrent production of high value coproducts. An acetic acid intermediate is produced from carbohydrates, such as corn, using enzymatic milling and fermentation steps, followed by conversion of the acetic acid... Agent: Sheridan Ross Pc

20090023193 - Anaerobic reactor and corresponding method for digesting organic material: The present invention is an anaerobic reactor and preferably a vertically oriented plug flow anaerobic reactor for producing methane from various organic materials. The organic materials preferably have a high organic content. The reactor includes cutting members for cutting bridged or agglomerated material within the reactor. The present invention also... Agent: Carlton Fields, P.a. Attn: Ip Dept.

20090023195 - Bio-based method for making mannitol: Mannitol is produced in a highly efficient fermentative method using Lactobacillus intermedius NRRL B-30560, or in a biochemical method using mannitol dehydrogenase isolated from this strain. Fructose serves as the primary carbon substrate in both the fermentative and biochemical conversions, but important secondary carbon sources include glucose, maltose, mannose and... Agent: Usda-ars-office Of Technology Transfer National Ctr For Agricultural Utilization Research

20090023196 - Stocks of replication-deficient adenovirus: Presented are ways to address the problem of replication-competent adenovirus in adenoviral production for use with, for example, gene therapy. Packaging cells having no overlapping sequences with a selected vector are suited for large scale production of recombinant adenoviruses. A system for use with the invention produces replication-defective adenovirus. The... Agent: Trask Britt

20090023199 - Micro-organism production system and method: A micro-organism production system having at least one micro-organism growth unit for maintaining therein micro-organisms in solution. Upon the receipt of a predetermined amount of live organisms, liquid and nutrients within the at least one micro-organism growth unit and the application of radiation thereto, the system produces the rapid growth... Agent: Burns & Levinson, LLP

20090023201 - Nucleic acid detecting cassette and nucleic acid detecting apparatus: In a nucleic acid detecting cassette in which a heating treatment chamber and a liquid delivery channel are constituted of a stationary member and flexible members, the heating treatment chamber is held by convex heating sections from both sides, whereby the heat treatment chamber and the liquid delivery channel are... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.c.

20090023202 - Nucleic acid analysis device and nucleic acid analyzer using the same: The present invention relates to a nucleic acid analysis device for analysis of nucleic acid in a sample through fluorometry, in which a localized surface plasmon by light irradiation, and in which a nucleic acid probe or a nucleic acid synthase for the analysis of the nucleic acid in the... Agent: Mcdermott Will & Emery LLP

20090023203 - Sensor device for interrogation of changes in the contents of a sealed container: A device and method allowing evaluation of the contents of a sealed primary container by means of an integral sensor which is separated from the contents of the sealed primary container yet provides information on quality of the contents of the primary container without breaking the sealed system. The integral... Agent: The Webb Law Firm, P.c.

20090023204 - A device for the storage and treatment of biodegradable wet solid waste: The present invention relates to a device for the storage and treatment of biodegradable wet solid waste, especially for vegetarian household waste materials. The device consists of a bucket shaped container with a mesh bottom and a removable cover with a hole at the center. The container is provided with... Agent: Greenlee Winner And Sullivan P C

20090023205 - Method for the separation of living cells: The present in invention relates to a method for the separation of living cells from a mixture of dead and living cells which optionally can also possibly contain cell fragments.... Agent: Mcdermott Will & Emery LLP

20090023206 - Microinjection apparatus and method of injecting fluid: A microinjection apparatus allows a capillary to stick into an object. A discharge pressure is supplied to the capillary. The supplied discharge pressure allows the discharge of a first fluid from the tip end of the capillary. The first fluid is injected into the object. The remains of the object... Agent: Westerman, Hattori, Daniels & Adrian, LLP

20090023207 - Chromosome 3p21.3 genes are tumor suppressors: Tumor suppressor genes play a major role in the pathogenesis of human lung cancer and other cancers. Cytogenetic and allelotyping studies of fresh tumor and tumor-derived cell lines showed that cytogenetic changes and allele loss on the short arm of chromosome 3 (3p) are most frequently involved in about 90%... Agent: Steven L. Highlander, Fulbright & Jaworski L.l.p. Suite 2400

20090023209 - Solution for the indefinite maintenance of nucleic acids in the cell of origin thereof: The invention relates to a product having characteristics which enable a biological sample obtained from an individual to be maintained under conditions such that the quality of nucleic acids later extracted is not affected, thereby guaranteeing the integrity of the sample regardless of the time that elapses between the sample... Agent: Schiff Hardin, LLP Patent Department

20090023210 - B-cyclodextrin derivatives and their use against anthrax lethal toxin: The invention provides low molecular weight compounds that block the pore formed by protective antigen and inhibit anthrax toxin action. Structures of the compounds are derivatives of β-cyclodextrin. Per-substituted alkylamino derivatives displayed inhibitory activity, and they were protective against anthrax lethal toxin action at low micromolar concentrations. Also, the addition... Agent: Keown & Zucchero, LLP

20090023211 - Blood platelet lysate and method of producing the same: A method of preparing a blood platelet lysate starting from platelet-rich plasma from whole blood of animals, to which blood a citrate has been added to prevent coagulation, is described. The method is characterised by concentrating the platelet-rich plasma by ultrafiltration to obtain a plasma that is richer in platelets,... Agent: Buchanan, Ingersoll & Rooney Pc

20090023216 - Double-stranded oligonucleotides: Antisense sequences, including duplex RNAi compositions, which possess improved properties over those taught in the prior art are disclosed. The invention provides optimized antisense oligomer compositions and method for making and using the both in in vitro systems and therapeutically. The invention also provides methods of making and using the... Agent: Invitrogen Corporation C/o Intellevate

20090023215 - Novel reagents for transfection of eukaryotic cells: Compositions and methods for improved delivery of macromolecules into eukaryotic cells are provided. Fusogenic peptides from fusion proteins of non-enveloped viruses enhance the efficiency of transfection of eukaryotic cells mediated by transfection agents such as cationic lipids, polycationic polymers such as PEI and dendrimers. These fusogenic peptides are used as... Agent: Proskauer Rose LLP

01/15/2009 > patent applications in patent subcategories.

20090017439 - Compositions and methods for enhancing the viability of animal cells, tissues, and organ explants: Disclosed are compositions and methods for the preservation, storage, and transport of living biological tissues, organs, and populations of isolated cells. In particular, the disclosed compositions and processes permit mammalian cells, tissues, and organs to be harvested from suitable donor animals, stored for prolonged periods, and transported to the site... Agent: Medtronic Attn: Noreen Johnson -IPLegal Department

20090017437 - Fixative composition: The invention relates to a fixative composition for preservation of tissue and biological samples. Current fixative compositions have the drawback that they do not sufficiently protect against DNA/RNA degeneration. In addition their use impairs extractability and compromises amplifiability of extracted DNA. The invention solves the combined but related problems and... Agent: Ladas & Parry LLP

20090017438 - Methods and compositions for the preservation of cells and tissues: Disclosed are methods for the preservation and storage of living biological tissues, organs, and populations of isolated cells. Also disclosed are compositions and methods to permit biological samples (including e.g., cells, cell cultures, tissues, and organs) to be harvested from suitable donor animals, stored for prolonged periods under refrigerated, cryogenic,... Agent: Medtronic Attn: Noreen Johnson -IPLegal Department

20090017440 - Increasing the viability and stress tolerance of viable biological material: The present invention relates to a method for improving viability and/or stress tolerance of viable biological material and using the said material comprising applying hydrostatic pressure to said biological material; keeping the said viable biological material at the hydrostatic pressure for a predetermined time period; releasing the hydrostatic pressure; and... Agent: Hahn & Voight PLLC

20090017447 - Human endogenous retrovirus with foamy-like properties and uses thereof: The invention relates to the discovery of a human endogenous retrovirus (HERV) family, Type I HERV-K (HML-2) which appear to be active in vitro and in vivo, infectious, and which have the have the salient features and properties of foamy retroviruses. Based on its natural replication in humans, and that... Agent: Ade & Company Inc.

20090017446 - Method and set of tools for checking the crystallisation conditions of biological macromolecules: The invention relates to a method and set of tools for checking and ascertaining the crystallisation conditions of biological macromolecules using the counter-diffusion technique which employs precipitating agents, additives and buffers. The concentration of the precipitating agent(s) in the medium (solution or gel) is greater than those currently used with... Agent: Wenderoth, Lind & Ponack, L.L.P.

20090017445 - Method for detecting and removing endotoxin: The present invention relates to bacteriophage tail proteins and the derivatives and fragments thereof that are capable of binding endotoxins in the absence of bivalent positive ions, especially Ca2+ or Mg2+. Further, the present invention relates to methods for depleting endotoxins from solutions and samples using the bacteriophage tail proteins... Agent: Fulbright & Jaworski L.L.P.

20090017443 - Method for detection of hepatitus b virus: To provide a method for detection or quantification of hepatitis B virus (HBV) antigens in serum and a simple and highly user-friendly method for sample treatment for use in the detection or quantification thereof. The method for treatment of a sample containing hepatitis B virus (HBV) is characterized in that... Agent: Birch Stewart Kolasch & Birch

20090017448 - Screening tool for antiviral agents: A method is provided for screening anti-adenovirus agents. The method includes reducing the activation of the immune system of a small mammal, administering a human adenovirus vector to the small mammal, monitoring the tumor cells in the mammal, and analyzing infectious virus units within the tumor cells and the organs... Agent: Husch Blackwell Sanders LLP

20090017454 - Biosensors, method for obtaining the same and uses thereof: The invention relates to biosensors, methods for obtaining them and their use for detecting, assaying or locating, in direct immunofluorescence, a ligand such as an antigen or hapten, in a heterogeneous population. The biosensor includes (i) at least one fragment of a receptor which is protein in nature, capable of... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20090017465 - Compound screening using cardiomyocytes: This invention provides populations human cells of the cardiomyocyte lineage. The cells are obtained by causing cultures of pluripotent stem cells to differentiate in vitro, and then harvesting cells with certain phenotypic features. Differentiated cells bear cell surface and morphologic markers characteristic of cardiomyocytes, and a proportion of them undergo... Agent: Geron Corporation Attn. David J. Earp

20090017456 - Detection, identification and differentiation of eubacterial taxa using a hybridization assay: The present invention relates to a method for the specific detection and/or identification of Enterococcus species, in particular Enterococcus faecalis and/or Enterococcus faecium, using new nucleic acid sequences derived from the ITS (Internal Transcribed Spacer) region. The present invention relates also to said new nucleic acid sequences derived from the... Agent: Nixon & Vanderhye, PC

20090017459 - Measuring analytes using competitive interference and recuperation of enzyme activity: The present teaching generally discloses a method of measuring the concentration of an analyte in a solution. The method includes selecting a binding compound; selecting an analog to an analyte and conjugating the analog to a polynucleotide substrate to construct a reagent for measuring the amount of the analyte in... Agent: Tips Group C/o Intellevate LLC

20090017452 - Methods and compositions relating to the pharmacogenetics of different gene variants: The present invention is directed to methods and compositions for determining the presence or absence of polymorphisms within an ABCC2, UGT1A1, and/or SLCO1B1 gene and correlating these polymorphisms with activity levels of their gene products and making evaluations regarding the effect on their substrates, particularly those substrates that are drugs.... Agent: Fulbright & Jaworski L.L.P.

20090017455 - Methods and systems for detecting and/or sorting targets: Provided herein are methods and systems for detecting and/or sorting targets in a sample based on the combined use of polynucleotide-encoded-protein and substrate polynucleotides. The polynucleotide-encoded protein is comprised of a protein that specifically binds to a predetermined target and of an encoding polynucleotide that specifically binds to a substrate... Agent: Steinfl & Bruno

20090017464 - Methods for drug discovery, disease treatment, and diagnosis using metabolomics: The small molecule profiles of cells are compared to identify small molecules which are modulated in altered states. Cellular small molecule libraries, methods of identifying tissue sources, methods for treating genetic and non-genetic diseases, and methods for predicting the efficacy of drugs are also discussed.... Agent: Lahive & Cockfield, LLP Floor 30, Suite 3000

20090017463 - Methods for predicting prostate cancer recurrence: The present invention relates to the identification of four cytokine biomarkers in prostatic tissue that exhibit differential expression following prostatectomy that, in combination at least one other factor, are able to reliably predict the development of biochemical recurrence following surgery. This marker combination improves the risk stratification of patients after... Agent: Fulbright & Jaworski L.L.P.

20090017450 - Primer for detection of human papillomavirus: Disclosed are primers specific to the genome of HPV genotypes 11, 16, 18 and 31. Also disclosed are a kit for detecting the HPV genome comprising the primers and a method of detecting the HPV genome using the primers.... Agent: Medlen & Carroll, LLP

20090017466 - Separation-free assay method: This invention relates to a separation-free assay method employing a binding partner label and a nonspecifically binding label, wherein a signal from said binding partner label or said nonspecifically binding label is measured in a binding event, said method comprising the use of a) two or more binding partners, and... Agent: James C. Lydon

20090017471 - Soluble erbb3 method of detection: The present invention discloses a method using human soluble ErbB3, for example p85-sErbB3, as a negative regulator of heregulin-stimulated ErbB2, ErbB3, and ErbB4 activation. The present invention also discloses p85-sErbB3 binding to heregulin with an affinity comparable to that of full-length ErbB3, and competitively inhibiting high affinity heregulin binding to... Agent: Tumor Biology Investment Group, Inc.

20090017472 - Biomarkers predictive of the responsiveness to tnfalpha inhibitors in autoimmune disorders: The invention provides methods for predicting responsiveness to TNFα inhibitors in a subject suffering from an autoimmune disorder, such as rheumatoid arthritis. The methods involve assaying for expression of one or more biomarkers in the subject that are predictive of responsiveness to TNFα inhibitors. A preferred biomarker of the invention... Agent: Lahive & Cockfield, LLP Floor 30, Suite 3000

20090017474 - Systems and methods for detecting abnormal cells: Systems and methods of interrogating clusters of cells for two or more biological markers that do not, or rarely, occur in the same cell during normal cellular growth, development and function, to indicate the existence of cells that are part of a local area where a pre-neoplastic or neoplastic lesion... Agent: Hamre, Schumann, Mueller & Larson, P.C.

20090017475 - Method to determine pseudo-allergic reactions: Method and kit for determining the possible appearance of adverse reactions (such as anaphylactoid reactions) in patients in need to undergo to an administration of a pharmaceutical compound. The method for determining potential hypersensitivity in a patient to pseudo-allergic reactions comprises adding a predetermined amount of a compound with anaphylatoxic... Agent: Bracco Research Usa Inc.

20090017477 - Method for determination of concentration, charge or unit size of a substance: This invention relates to a method comprising the steps of a) contacting a sample containing a sample substance and a solid phase comprising a signal element, and optionally a substance containing a signal element, i.e. a signal element substance; wherein at least one of said sample substance, said solid phase,... Agent: James C. Lydon

20090017469 - Use of holographic sensor: The present invention relates to a process for the detection of an analyte in a sample, comprising a) bringing the sample into contact with a first ligand which binds specifically to the analyte and which is immobilised on a substrate, and b) prior to or subsequent to step (a), bringing... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20090017480 - Bioamplification for microbial sensor signal transduction: A process of detection of the causative agent of Johne's disease (Mycobacterium avium subsp. paratuberculosis) (MAP) by detecting shedding of surface protein of MAP. A preferred way is use of surface enhanced Raman Spectroscopy. The system of detecting MAP shedding of protein provides early detection and diagnosis, and therefore allows... Agent: Mckee, Voorhees & Sease, P.L.C

20090017482 - Luminogenic and nonluminogenic multiplex assay: A method to detect the presence or amount of at least one molecule for an enzyme-mediated reaction in a multiplex luminogenic/nonluminogenic assay is provided.... Agent: Schwegman, Lundberg, Woessner & Kluth, P.A.

20090017485 - Alzheimer's disease examination method: [Means for Solving Problems] A reaction liquor, which is prepared by mixing an amyloid β protein with a body fluid collected from a subject and a buffer solution is reacted. After the polymerization of the amyloid β protein comes to equilibrium, the degree of the amyloid β protein polymerization is... Agent: Kanesaka Berner And Partners LLP

20090017483 - Analytical instrument having improved arrangement of reagent section and analytical method: The present invention relates to an analytical instrument (1) which includes a flow path (5) for moving a sample containing blood cells, an introduction port (50) for introducing the sample into the flow path (5), a reagent portion (51) arranged in the flow path (5), and an electron detection medium... Agent: Hamre, Schumann, Mueller & Larson, P.C.

20090017484 - Markers for atherosclerosis: A method for the diagnosis, prognosis or identification of a predisposition towards atherosclerosis and the susceptibility to the development of atherosclerotic plaques and/or vascular obstruction is described, the method comprising analysing a sample to determine the percentage frequency of multiple sub-populations of T-lymphocytes and comparing the data obtained against comparative... Agent: Edwards Angell Palmer & Dodge LLP

20090017490 - Dna fragment method for producing transformant for protein production and utilization thereof: An expression vector is constructed by transferring recombinant tomato mosaic virus (ToMV) cDNA, in which a coat protein gene of ToMV having a suppressor against a virus resistant reaction has been substituted by a GFP gene, into the downstream of a promoter capable of inducing steroid hormone-dependent transcription. In a... Agent: Harness, Dickey & Pierce, P.L.C

20090017491 - Apparatus and method for biological sample processing: An apparatus and method are described that achieve independent and simultaneous processing of a plurality of substrate-supported biological samples. In one embodiment, substrate holders arranged in a minor arc are independently moveable between a processing position and an access position, and reagents are delivered to substrates held in the substrate... Agent: Ventana Medical Systems, Inc. Attention: Legal Department

20090017493 - Gene sms 02: The present invention relates to newly identified genes that encode proteins that are involved in the synthesis of L-ascorbic acid (hereinafter also referred to as Vitamin C). The invention also features polynucleotides comprising the full-length polynucleotide sequences of the novel genes and fragments thereof, the novel polypeptides encoded by the... Agent: Nixon & Vanderhye, PC

20090017492 - Svph1-26 dna and polypeptides: DNA encoding SVPH1-26 polypeptides and methods for using the encoded proteinase and polypeptides are disclosed. SVPH1-26 is expressed in testis.... Agent: Immunex Corporation Law Department

20090017496 - Co-expression of multiple protein chains or subunits: A recombinant genetic construct is provided that includes at least two expression cassettes. Each cassette encodes for a chain or subunit of a target protein. The genetic construct preferably targets any expressed protein to the secretory pathway of the host cell. An application of present invention is found in expressing... Agent: Duan Wu

20090017500 - Interferon-alpha polypeptides and conjugates: The present invention provides interferon-alpha polypeptides and conjugates, and nucleic acids encoding the polypeptides. The invention also includes compositions comprising these polypeptides, conjugates, and nucleic acids; cells containing or expressing the polypeptides, conjugates, and nucleic acids; methods of making the polypeptides, conjugates, and nucleic acids; and methods of using the... Agent: Maxygen, Inc. Intellectual Property Department

20090017501 - Interferon-alpha polypeptides and conjugates: The present invention provides interferon-alpha polypeptides and conjugates, and nucleic acids encoding the polypeptides. The invention also includes compositions comprising these polypeptides, conjugates, and nucleic acids; cells containing or expressing the polypeptides, conjugates, and nucleic acids; methods of making the polypeptides, conjugates, and nucleic acids; and methods of using the... Agent: Maxygen, Inc. Intellectual Property Department

20090017502 - Interferon-alpha polypeptides and conjugates: The present invention provides interferon-alpha polypeptides and conjugates, and nucleic acids encoding the polypeptides. The invention also includes compositions comprising these polypeptides, conjugates, and nucleic acids; cells containing or expressing the polypeptides, conjugates, and nucleic acids; methods of making the polypeptides, conjugates, and nucleic acids; and methods of using the... Agent: Maxygen, Inc. Intellectual Property Department

20090017499 - Rank ligand-binding polypeptides: The present invention relates to a polypeptide having an amino acid sequence that differs from and is at least 70% identical to the amino acid sequence of hRANK, and which has a binding affinity to RANKL that is at least as high as the binding affinity of hRANK to RANKL,... Agent: Maxygen, Inc. Intellectual Property Department

20090017503 - Method and apparatus for saccharide precipitation from pretreated lignocellulosic materials: A method for separating saccharide components and lignin fractions from a concentrated acid treated lignocellulosic biomass is disclosed. The method involves precipitating the saccharide components by adding an organic solvent to the biomass slurry. The acid may then be recovered, for example, by filtration or by countercurrent washing and the... Agent: Lathrop & Gage Lc

20090017505 - Process and device for mixing microdroplets: In a process for mixing microdroplets (2a, 2b, 2c), at least two carriers (3a, 3b) are provided whose surfaces (4a, 4b) are each structured in such a way that at least one hydrophilic surface domain (5a, 5b) is delimited by at least one hydrophobic surface domain (6a, 6b). A first... Agent: The Webb Law Firm, P.C.

20090017506 - Continuous fermentation process to produce bacterial cellulosic sheets: A process to obtain multiple bacterial cellulose sheets without the need to replace new fermentation medium in the tray is provided. The medium is prepared and medium components in water are dissolved. The medium is sterilized and heated to 115° C. for 20 minutes, cooled to 30° C., inoculated with... Agent: Volpe And Koenig, P.C.

20090017507 - Dry granulated product containing l-lysine as main component: Hydrochloric acid, sulfuric acid or an L-lysine solution having an equivalent ratio of anion/L-lysine higher than 0.95 is added to a raw material L-lysine solution having an equivalent ratio of anion/L-lysine lower than 0.68 to adjust the equivalent ratio of anion/L-lysine of the raw material solution to be in the... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20090017508 - Streptomyces avermitilis gene directing the ratio of b2:b1 avermectins: The present invention relates to polynucleotide molecules comprising nucleotide sequences encoding an aveC gene product, which polynucleotide molecules can be used to alter the ratio or amount of class 2:1 avermectins produced in fermentation cultures of S. avermitilis. The present invention further relates to vectors, host cells, and mutant strains... Agent: Pfizer Inc.

20090017509 - Method for the production of ramipril: An improved method for preparing ramipril is disclosed, and also an intermediate for use in the method.... Agent: Andrea Q. Ryan Sanofi-aventis U.s. LLC

20090017510 - Enzymic method for the enantioselective reduction of keto compounds: The invention relates to an enzymatic method for the enantioselective reduction of organic keto compounds to the corresponding chiral hydroxy compounds, an alcohol dehydrogenase from Lactobacillus minor and a method for the enantioselective production of (S)-hydroxy compounds from a racemate.... Agent: Propat, L.L.C.

20090017511 - Alcohol product processes: The present invention relates to processes for production of an alcohol product from granular starch comprising a pre-treatment at an elevated temperature below the initial gelatinization temperature of said granular starch followed by simultaneous saccharification and fermentation, and optionally recovery of ethanol.... Agent: Novozymes North America, Inc.

20090017512 - Apparatus and methods for the production of ethanol, hydrogen and electricity: The compositions, methods and apparatus of the present invention allow the production of electricity, ethanol and hydrogen, and combinations thereof. In some embodiments, the invention provides a process for generating electricity or hydrogen comprising supplying a microbial catalyst and a fuel source to a microbial fuel cell or a bio-electrochemically... Agent: Fulbright & Jaworski L.L.P.

20090017513 - Process for producing hydrocarbon molecules from renewable biomass: Provided is a process for producing hydrocarbon molecules from biomass utilizing microorganisms that are resistant to extreme heat and pressure, that comprise nucleic acid molecules encoding enzymes which degrade compounds selected from the group consisting of cellulose, lignin, xylan and hemicellulose, and which are capable of generating hydrocarbon molecules from... Agent: Hunton & Williams/new York Intellectual Property Dept.

20090017514 - Membrane supported bioreactor for conversion of syngas components to liquid products: Ethanol and other liquid products are produced by contacting syngas components such as CO or a mixture of CO2 and H2 with a surface of a membrane under anaerobic conditions and transferring these components in contact with a biofilm on the opposite side of the membrane. These steps provide a... Agent: Cardinal Law Group

20090017515 - Process for microbial production of a valuable compound: The present invention relates to a process for the production of a valuable compound by cultivation of a microorganism comprising cultivating the microorganism in a medium wherein all nutrients are provided in excess over the whole cultivation period and wherein a suitable amount of oxygen is fed to the culture... Agent: Nixon & Vanderhye, PC

20090017516 - Target physiological function inactivator using photosensitizer-labeled fluorescent protein: An object of the present invention is to provide a method of generating reactive oxygen species in a light irradiation-dependent manner, so as to inactivate any target physiological function. The present invention provides a target physiological function inactivator which consists of a photosensitizer-labeled fluorescent protein, wherein fluorescence resonance energy transfer... Agent: Greenblum & Bernstein, P.L.C

20090017519 - Enzyme preparations for use as biocatalysts: The invention is directed to enzyme preparations which are obtainable by enzyme immobilizates which comprise enzymes or microorganisms containing enzymes immobilized on an inert carrier being provided with a silicone coating obtained by hydrosilylation, to a process for producing such enzyme preparations and to the use of enzyme preparations as... Agent: Frommer Lawrence & Haug

20090017520 - Process and materials for production of glucosamine: The present invention relates to a method and materials for producing glucosamine by fermentation of a genetically modified microorganism. Included in the present invention are genetically modified microorganisms useful in the present method for producing glucosamine, as well as recombinant nucleic acid molecules and the proteins produces by such recombinant... Agent: Sheridan Ross PC

20090017521 - Chimaeric phages: The invention relates to the field of generating helper phages and phage display libraries for the identification of binding molecules. The invention provide chimaeric phages having a coat comprising a protein mixture. The protein mixture comprises a fusion protein having a proteinaceous molecule fused to a functional form of a... Agent: Trask Britt

20090017523 - Virus purification methods: Provided is a method for purifying a virus from a host cell, the method comprising: a) culturing host cells, b) infecting the host cells with a virus, c) treating the cell culture with nuclease, and d) lysing the host cells to provide a lysate comprising the virus. The virus may... Agent: Trask Britt

20090017524 - Product for the treatment of wastewaters and sewage: Biodegradable support carrying a mixture of non-pathogenic bacteria that synergistically cooperate in decomposing the organic pollutants present in toilet wastewaters and in sewage collection and processing tanks.... Agent: Arent Fox LLP

20090017525 - S-triazine-herbicide-degrading bacteria, product for the bioremediation and method of bioremediation: The present invention provides a bacterial strain which is able to degrade or mineralize s-triazine compounds, such as simazine, which corresponds to Pseudomonas sp. strain MHP41, deposited under the accession number NRRL B-30908. The present invention provides a product for the bioremediation of environments contaminated with s-triazine, where the product... Agent: Merchant & Gould PC

20090017526 - Method of using endophytic fungi to decontaminate and decompose human and animal wastes: A method of treating human and/or animal waste products comprising contacting the waste products with an effective amount of Fusarium culmorum and Muscodor albus, together with a buffering agent and starch. The treatment process covered by the present invention can be employed in connection with pit toilets, portal a toilets,... Agent: Antoinette M. Tease

20090017527 - Advanced genetic vaccines: Reagents useful in nucleic acid immunization techniques are described. More particularly, adjuvanted genetic vaccine compositions are described, as are methods of using those compositions for inducing an enhanced immune response against a selected antigen.... Agent: Foley And Lardner LLP Suite 500

20090017528 - Nucleic acid hybridization device: The present invention relates to a hybridization device coupled by means of vibration to shorten the time needed for hybridization. This hybridization device of the present invention comprises an oscillation generating unit; a spacer attached to the top of the oscillation generating unit, which wraps around to form a tank,... Agent: Wpat, PC Intellectual Property Attorneys

20090017529 - Scalable wall bioreactor for culture of plant and animal tissues: A flexible wall bioreactor is described that uses a small droplet size mist unit, a lower rate ambient air flow rate, and a flexible wall culture chamber to provide an environment that allows for the growth of dense root matrix, shoot cultures, and 2 and 3 dimensional animal tissues.... Agent: Burns & Levinson, LLP

20090017531 - Method for isolating plasmids from suspended bacterial or yeast cells: A method for isolating plasmids from suspended bacterial or yeast cells using a filter matrix, at least one lysing substance being added to the suspension and predamaging or completely lysing the predominant portion of the suspended cells, at least one conformation-altering substance being added to the suspension to alter the... Agent: Rankin, Hill & Clark LLP

20090017532 - Vector: A vector comprising a nucleotide sequence of interest (“NOI”) encoding a product of interest (“POI”) is described. The NOI and/or the POI is capable of recognizing a tumor, such that in use the vector is capable of delivering the NOI and/or the POI to the tumor.... Agent: Marshall, Gerstein & Borun LLP

20090017533 - Optimized messenger rna: The present invention is directed to a synthetic nucleic acid sequence which encodes a protein wherein at least one non-common codon or less-common codon is replaced by a common codon. The synthetic nucleic acid sequence can include a continuous stretch of at least 90 codons all of which are common... Agent: Lowrie, Lando & Anastasi, LLP

20090017534 - Slo2 and slo4, novel potassium channel proteins from human brain: The invention provides isolated nucleic acid and amino acid sequences of Slo2 and Slo4, members of the Slo family of potassium channel proteins, also known as “maxi” or BK potassium channel proteins. Also provided herein are antibodies to Slo2 and Slo 4, methods of detecting Slo2 and Slo 4, methods... Agent: Townsend And Townsend And Crew, LLP

20090017536 - Modified vaccinia ankara virus variant and cultivation method: The present invention provides an attenuated virus, which is derived from Modified Vaccinia Ankara virus and characterized by the loss of its capability to reproductively replicate in human cell lines. It further describes recombinant viruses derived from this virus and the use of the virus, or its recombinants, as a... Agent: Law Office Of Salvatore Arrigo

20090017537 - Ht2r54 receptor polypeptides and nucleic acid sequences: Functional assays that detect the effect of a particular compound or compounds on the activation of at least one human T2R polypeptide are provided. These assays include e.g., assays which detect the effect of said compound on intracellular calcium, second messengers such as cAMP, cGMP, current e.g., by use of... Agent: Hunton & Williams LLP Intellectual Property Department

20090017540 - Method of culturing cells under regulation in the extension direction: [Means for Solving Problems]A cell culture plate having a plural number of side walls (1) and a plural number of space structures (3) for providing cultured cells which are formed by the side walls (1), wherein the side walls (1) are provided with openings (2) so that the space structures... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20090011399 - Method and apparatus for biopsy sample processing: A container for use in processing a biopsy sample. Biopsy sample and materials are received within a sample processing area of the container. A semi-permeable barrier is positioned at a downstream portion of the sample processing area and prevents the prevent passage of the biopsy sample. A cap is positioned... Agent: Wolf Greenfield & Sacks, P.C.

20090011401 - Group of reagent carriers that is combined to form a composite: The invention concerns a group of reagent carriers that is combined to form a composite, each one of said carriers having at least one test region located in a shallow trough-like depression, where the reagent carriers in the composite are held together exclusively by interconnected protective covers for the test... Agent: Dinsmore & Shohl, LLP One Dayton Centre

20090011402 - Biosensors based on directed assembly of particles: A sensor system for detecting an effector or cofactor comprises (a) a nucleic acid enzyme; (b) a substrate for the nucleic acid enzyme, comprising a first polynucleotide; (c) a first set of particles comprising a second polynucleotide at least partially complementary to the substrate, where the polynucleotide is attached to... Agent: Evan Law Group LLC

20090011403 - Microporous materials, methods of making, using, and articles thereof: Described herein are methods for separating one or more analytes present in a fluid sample. The methods involve passing the fluid through or into a microporous material, wherein the analytes are localized near the surface of the microporous material. Additional processing steps such as hybridization and amplification can be performed... Agent: Ballard Spahr Andrews & Ingersoll, LLP

20090011409 - Antibodies against cells of fetal origin: This invention relates to antibodies that specific bind to fetal CD36+ cells in preference to binding to maternal CD36+ cells and methods for using these antibodies to detect and separate fetal cells from adult biological fluids including maternal peripheral blood.... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20090011424 - Cancer-suppressing agents: It is an object of the present invention to provide a cancer-suppressing agent comprising a novel cancer-suppressing gene based on the discovery of such cancer-suppressing gene. The present invention provides a cancer-suppressing agent which comprises NR1I2 gene or a homologous gene thereof; and a cancer-suppressing agent which comprises NR1I2 protein... Agent: Birch Stewart Kolasch & Birch

20090011418 - Functional toll-like receptors (tlr) on melanocytes and melanoma cells and uses thereof: The invention relates to a method of detecting Toll-like receptor (TLR) gene expression or protein activity in a melanocyte or melanoma cell. Also disclosed are a method of modulating TLR gene expression or protein activity in a melanocyte or melanoma cell by contacting the cell with a TLR modulating agent... Agent: Hogan & Hartson L.L.P.

20090011412 - Hip1 cancer markers: The present invention relates to compositions and methods for cancer diagnostics, including but not limited to, HIP1 cancer markers. In particular, the present invention provides compositions and methods of using HIP1 in the diagnosis and treatment of lymphoma and brain cancers.... Agent: Casimir Jones, S.c.

20090011414 - Human autism susceptibility gene encoding a kinase and uses thereof: The present invention discloses the identification of a human autism susceptibility gene, which can be used for the diagnosis, prevention and treatment of autism and related disorders, as well as for the screening of therapeutically active drugs. The invention more specifically discloses that the MARK1 gene on chromosome 1 and... Agent: Occhiuti Rohlicek & Tsao, LLP

20090011411 - Method for detecting and quantifying endogenous wheat dna sequence: It is an object of the present invention to provide partial sequences of endogenous wheat DNA (genome) which are single copies and which allow wheat to be specifically detected without cross-reacting with other plants in PCR, and to provide primers for amplifying these partial sequences, along with a good method... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20090011410 - Method for tailoring administration of drugs by quantitation of mrna: The present invention discloses a method for tailoring drug protocols to individual patients based on the levels of marker mRNA measured in leukocytes after stimulation of whole blood of the patient with candidate drugs. A method of measuring a patient's responsiveness to a drug is disclosed that includes exposing whole... Agent: Knobbe Martens Olson & Bear LLP

20090011406 - Method of judging fatigue: A method of judging fatigue, which comprises judging fatigue by using, as an index, a value obtained by quantitatively analyzing an adenine nucleotide in a sample to be measured.... Agent: Greenblum & Bernstein, P.L.C

20090011422 - Methods for cloning small rna species: This invention pertains to methods for cloning microRNA (miRNA) and other small ribonucleic acid (RNA) species from relevant cell sources.... Agent: John Petravich Integrated Dna Technologies, Inc.

20090011405 - Modulating screening thresholds for n-hybrid screening: The present invention provides improved N-hybrid assays. In particular, the present invention provides an improved reverse N-hybrid assay comprising modulating the amount of a substrate of a reporter gene and/or the amount of a reporter gene thereby enhancing cell death in the absence of a peptide inhibitor of a DNA-protein... Agent: Knobbe Martens Olson & Bear LLP

20090011407 - Polymorphic cd24 genotypes that are predictive of multiple sclerosis risk and progression: An image data correction apparatus has a motion information acquisition section, a correction section, and a composition section. The motion information acquisition section acquires motion information indicating spatial distribution of the magnitude of motion, in actual space, of a to-be-imaged portion of a subject. Based on the motion information, the... Agent: Calfee Halter & Griswold, LLP

20090011419 - Probe, probe set, probe carrier, and testing method: A probe, a set of probes, and a probe carrier on which the probe or the set of probes is immobilized, are provided for classification of fungus species. The probe or the set of probes is capable of collectively detecting fungus of the same species and distinguishingly detecting those fungus... Agent: Fitzpatrick Cella Harper & Scinto

20090011416 - Random array dna analysis by hybridization: The invention relates to methods and devices for analyzing single molecules, i.e. nucleic acids. Such single molecules may be derived from natural samples, such as cells, tissues, soil, air and water without separating or enriching individual components. In certain aspects of the invention, the methods and devices are useful in... Agent: Morgan, Lewis & Bockius, LLP

20090011420 - Sparsely cross-linked nanogels: a novel polymer structure for microchannel dna sequencing: The present invention is generally directed to novel polymeric materials for use in the electrophoretic separation of nucleic acids. In particular, the novel polymer materials are sparsely crosslinked nanogels, dissolved in an aqueous buffer to form solutions with moderate to high viscosity. The present invention further provides methods for generating... Agent: Casimir Jones, S.c.

20090011421 - Susceptibility to bone damage: In one aspect, the present invention provides methods for determining susceptibility to bone damage in a subject. In some embodiments, the methods comprise screening for polymorphisms in the MTHFR and collagen Iα1 genes that are associated with susceptibility to bone damage. In some embodiments, the methods comprise screening for elevated... Agent: Sheridan Ross PC

20090011427 - Assays for preimplantation factor and preimplantation factor peptides: The present invention relates to assay methods used for detecting the presence of PIF, and to PIF peptides identified using this assay. In particular, the present invention relates to flow cytometry assays for detecting PIF. It is based, at least in part, on the observation that flow cytometry using fluorescently... Agent: Pepper Hamilton LLP

20090011429 - Diagnosis of pre-eclampsia: The present invention relates to a method of predicting pre-eclampsia (PE). The present invention also relates to a diagnostic kit for performing a method of predicting PE. In particular, the method determining the level of two or more markers selected from placenta growth factor (P1GF), plasminogen activator inhibitor-1 (PAI-1), plasminogen... Agent: Banner & Witcoff, Ltd.

20090011428 - Fluid membrane-based ligand display system for live cell assays and disease diagnosis applications: A supported membrane based, strategy for the presentation of soluble signaling molecules to living cells is described. In this system, the fluidity of the supported membrane enables localized enrichment of ligand density in a configuration reflecting cognate receptor distribution on the cell surface. Display of a ligand in non-fluid supported... Agent: Lawrence Berkeley National Laboratory

20090011425 - Incubation device for serology and histology slides: This application relates to an incubation device for serology or histology supports. It also relates to any apparatus comprising one such device, and to the use of said apparatuses and/or devices in analysis or diagnosis methods.... Agent: Heslin Rothenberg Farley & Mesiti PC

20090011426 - Methods of diagnosis and treatment of m.tuberculosis infection and reagents therefor: The present invention provides diagnostic, prognostic and therapeutic reagents for infection of an animal subject such as a human by M. tuberculosis, and conditions associated with such infections, such as, for example, tuberculosis. More particularly, the present invention provides a recombinant protein of M. tuberculosis designated “BSX” (SEQ ID NO:... Agent: Cozen O'connor, P.C.

20090011430 - Electrical detection using confined fluids: A device having: a laminar flow channel for liquids; two or more electrodes; a confining fluid inlet; a sample inlet; and a meter for measuring the impedance of any fluid between the electrodes. The device may have one or more specific binding sites, or it may have sheathing and unsheathing... Agent: Naval Research Laboratory Associate Counsel (patents)

20090011441 - Novel methods of cancer diagnosis and therapy targeted against a cancer stem line: Improved methods for treatment of cancer which involve the targeting of slow-growing, relatively mutationally-spared cancer stem line are provided. These methods are an improvement over previous cancer therapeutic methods because they provide for very early cancer treatment and reduce the likelihood of clinical relapse after treatment.... Agent: Jones Day

20090011439 - Prognosis and therapy predictive markers and methods of use: Disclosed is a set of genes differentially expressed in chemotherapy and radiation resistant tumors useful in predicting response to therapy and assessing risk of local-regional failure, survival and metastasis in cancer patients. Also disclosed are methods for characterizing tumors according to gene expression and kits for use in the methods... Agent: Michael Best & Friedrich LLP

20090011440 - Receptor tyrosine kinase signaling pathway analysis for diagnosis and therapy: The invention provides a method for determining the activation status of receptor tyrosine kinase (RTK) pathways in either cell samples or patient samples by measuring receptor dimerization and relative amounts of protein-protein complexes or activated effector proteins that are characteristic of an RTK pathway. The invention also provides a method... Agent: Monogram/fenwick

20090011432 - Detecting and profiling molecular complexes: Methods are provided for detecting the formation of complexes of molecules, especially proteins, in a sample, such as a cell or tissue lysate. In one aspect, a cleaving probe specific for a first protein in a complex and one or more binding compounds specific for one or more second proteins... Agent: Monogram/fenwick

20090011435 - Assays for detecting antibodies to therapeutics: The disclosed invention relates to methods and devices for detecting a biologic in a test sample. In particular, the disclosed assay utilizes EPO as a target to detect endogenous anti-EPO antibodies in a sample and does not manipulate or modify the target EPO antibody.... Agent: Morrison & Foerster LLP

20090011434 - Methods and compositions for diagnosing breast cancer: Mammastatin has an approximate molecular weight of 44 kDa in its inactive, non-phosphorylated form. Normal mammary cells express functional phosphorylated forms having approximate molecular weights of 53 kDa and 49 kDa. Metastatic mammary cells either do not express Mammastatin at all, or do not express the 53 kDa or 49... Agent: Casimir Jones, S.c.

20090011444 - Detection and diagnosis of inflammatory disorders: Soluble H4 (sH4) levels have been discovered to correlate with the stage or severity of inflammatory disorders including autoimmune disorders. In particular, circulating levels of sH4 can be used as a diagnostic for determining the severity of an inflammatory disorder or the propensity for developing an inflammatory disorder. The severity... Agent: Patrea L. Pabst Pabst Patent Group LLP

20090011445 - Method and apparatus for in vivo collection of circulating biological components: The invention relates generally to in vivo collection of circulating molecules, tumor cells and other biological markers using a collecting probe. The probe is configured for placement within a living organism for an extended period of time to provide sufficient yield of biological marker for analysis. In some embodiments of... Agent: Knobbe Martens Olson & Bear LLP

20090011448 - Pretreatment agent for limulus test: A pretreatment agent for a sample to be subjected to Limulus assay comprising an alkali metal sulfate and/or an alkaline earth metal sulfate wherein the sulfate(s) has a final concentration of 20 mM or more when the sulfate(s) is allowed to contact with the sample, or an alkali metal halide... Agent: Sughrue-265550

20090011447 - Quantification of vitellogenin: The present invention is directed to a simple method for absolute quantification of plasma vitellogenin from two or more different fish species such as Rainbow trout and Atlantic salmon, or Atlantic cod and haddock. In the case of Rainbow trout and Atlantic salmon, plasma samples obtained from control and β-estradiol... Agent: The Farrell Law Firm, P.C.

20090011449 - No calibration analyte sensors and methods: A meter and sensors, for use in combination, where no calibration code has to be entered by the user or is read by the meter. The meter is configured with a predetermined slope and y-intercept built into the meter. If the slope and y-intercept of the sensor are within a... Agent: Bozicevic, Field & Francis LLP

20090011450 - Dry analytical element for lipase measurement: It is an object of the present invention to provide a dry analytical element for pancreatic lipase analysis having high selectivity with respect to pancreatic lipase, whose multianalyte correlation has been improved. The present invention provides a dry analytical element for measurement of pancreatic lipase contained in a body fluid,... Agent: Birch Stewart Kolasch & Birch

20090011455 - Disease model incorporation into an artificial immune system (ais): The present invention relates to methods of constructing an integrated artificial immune system that comprises appropriate in vitro cellular and tissue constructs or their equivalents to mimic the tissues of the immune system in mammals. The artificial immune system can be used to test the efficacy of vaccine candidates and... Agent: Merchant & Gould PC

20090011454 - Fluorescent sensors for cellular amines: The invention provides compounds of formulas I, II, and III, methods of making them, and methods of their use. The compounds of the invention can be used as fluorescent sensors, for example, to detect an amine-containing analyte in a biological sample. The compounds can be selective for one type of... Agent: Schwegman, Lundberg & Woessner, P.A.

20090011452 - Method of prognosis of mental diseases, e.g. autism and cerebral palsy: The invention provides a method of prognosis for applied behavioral analysis treatment of mental disease, in particular autism or cerebral palsy, in a human subject. The method includes analyzing a sample of body tissue or fluid from the subject for the presence or absence of a chemical marker indicative of... Agent: Knobbe Martens Olson & Bear LLP

20090011453 - Methods for producing proteins using hamster igf-1: A polypeptide selected from the group consisting of: (1) a polypeptide having the amino acid sequence of SEQ ID NO: 1, and (2) a polypeptide having an amino acid sequence in which the third amino acid of the amino acid sequence of SEQ ID NO: 1 is substituted by another... Agent: Foley And Lardner LLP Suite 500

20090011457 - Method and device for testing the bactericidal effect of substances: The method for checking the degree of microbial loading of laundry after a wash cycle is characterized in that a defined amount of living microorganisms are washed together with the laundry, in that the number of microorganisms still living after the end of the wash process is determined and in... Agent: Moetteli & Associates Sarl

20090011458 - Method for selectively staining microorganisms: A method for selectively flagging target microorganisms in a liquid sample also including background particles comprises the steps of adding a lysing agent selected to breach the background particles to the sample, adding a dye selected to flag the target microorganisms to the sample, adding a suppressing agent selected to... Agent: Jennifer L. Bales

20090011460 - Calcium-binding photoprotein, gene encoding the same, and use thereof: A protein according to the invention can be used to detect or measure calcium ions is provided. Further the protein is useful as a reporter protein or a luminescence marker. A polynucleotide according to the invention is also useful as a reporter gene.... Agent: Hogan & Hartson LLPIPGroup, Columbia Square

20090011463 - Pcka modifications and enhanced protein expression in bacillus: The present invention provides cells that have been genetically manipulated to have an altered capacity to produce expressed proteins, wherein the pckA gene has been modified or deleted. In particular, the present invention relates to Gram-positive microorganisms, such as Bacillus species having enhanced expression of a protein of interest, wherein... Agent: Genencor International, Inc. Attention: Legal Department

20090011465 - Interferon-alpha polypeptides and conjugates: The present invention provides interferon-alpha polypeptides and conjugates, and nucleic acids encoding the polypeptides. The invention also includes compositions comprising these polypeptides, conjugates, and nucleic acids; cells containing or expressing the polypeptides, conjugates, and nucleic acids; methods of making the polypeptides, conjugates, and nucleic acids; and methods of using the... Agent: Maxygen, Inc. Intellectual Property Department

20090011466 - Concatameric immunoadhesion molecule: Disclosed are concatameric proteins comprising two soluble domains, in which the C-terminus of a soluble domain of a biologically active protein is linked to the N-terminus of an identical soluble domain or a distinct soluble domain of a biologically active protein. Also, the present invention discloses dimeric proteins formed by... Agent: Greenblum & Bernstein, P.L.C

20090011468 - Method for improving protein production: The present invention relates to the production of proteins in a cell or host cell. The invention uses a TRAnscription Pause (TRAP) sequence to enhance a protein expression characteristic of a protein expression unit. The TRAP sequence is thought to prevent, at least in part, formation of antisense RNA or... Agent: Trask Britt

20090011467 - Novel fructosyl peptide oxidase: A novel fructosyl peptide oxidase having physicochemical properties useful as an enzyme for clinical diagnosis, and a method for producing a novel fructosyl peptide oxidase are provided herein, the method comprising: culturing a microorganism capable of producing the oxidase in a medium; and collecting the oxidase from the culture. Furthermore,... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20090011469 - Method and formulation for the extraction of nucleic acids from any complex starting materials: The invention relates to a universal and greatly simplified method as well as a composition for isolating nucleic acids from different starting materials containing nucleic acids. The composition contains at least one buffer solution for proteolytically solubilizing biological samples, the buffer containing no chaotropic or antichaotropic component, at least one... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20090011470 - Nucleic acid sample preparation by exclusion of dna: Devices and methods are provided for separation of nucleic acids from waste materials in a biological sample, and then reacting the separated nucleic acids. In some embodiments, the methods comprise mixing a cell lysate having nucleic acids and waste materials with a waste-binding matrix to capture the cellular waste materials... Agent: Kilyk & Bowersox, P.l.l.c.

20090011471 - Engineered plasmids and their use for in situ production of genes: Nucleic acid sequences encoding at least a portion of a polypeptide are directly incorporated into a plasmid by DNA polymerization or reverse transcription of a nucleic acid template. In particularly preferred embodiments, nucleic acid sequences encoding at least a portion of an antibody are directly incorporated into a plasmid by... Agent: Ropes & Gray LLP

20090011472 - Isothermal dna amplification: Provided herein are nucleic acid synthesis methods and agents that employ an endonuclease for example, endonuclease V, to introduce a nick into a target DNA including one or more inosine, and uses a DNA polymerase to generate amplicons of the target DNA.... Agent: General Electric Company Global Research

20090011474 - Process for producing sugars from cellulosic biomass: A process for increasing production of sugars from cellulose in a plant biomass using ammonia after swelling of the biomass with water and enzymatic hydrolysis is described. The sugars are preferably fermented to an alcohol, particularly ethanol as a fuel for vehicles.... Agent: Ian C. Mcleod, P.C.

20090011473 - Saccharifying cellulose: Dissolution, partial dissolution or softening of cellulose in an ionic liquid (IL) and its subsequent contact with anti-solvent produces regenerated cellulose more amorphous in structure than native cellulose, which can be separated from the IL/anti-solvent mixture by mechanical means such as simple filtration or centrifugation. This altered morphology of IL-treated... Agent: Emch, Schaffer, Schaub & Porcello Co

20090011404 - Methods and compositions for optical detection of single-stranded polynucleotides: The invention relates to products and methods for determining, localizing, and quantitating single-stranded polynucleotides. The methods of the invention include the use of Gp32F protein and mutant Gp32F protein to monitor polynucleotide reactions such as DNA replication, annealing, and excision and to determine single-stranded polynucleotide structures such as gaps, flaps,... Agent: Wolf Greenfield & Sacks, P.C.

20090011476 - Gene cluster and method for the biosynthesis of terrequinone a: The present invention provides a novel gene cluster containing five genes (tdiA-E) involved in indole alkaloid synthesis. Disruption of tdiB, encoding an enzyme with prenyltransferase activity, transferring dimethylallylpyrophosphate to C-2 of an indole structure, eliminated the production of the antitumor compound terrequinone A, a metabolite not known from A. nidulans.... Agent: Quarles & Brady LLP

20090011477 - Stability of secondary metabolite mass production through synchronized plant cell cultures: This invention is a method of minimizing the variation of cell growth and production through homogeneous cell line development. To be more specific, it is the method of isolating and proliferating single cell clone from the procambium to promote the stability of the plant-derived biologically active substances production by solving... Agent: Moore & Van Allen PLLC

20090011478 - Biochemical synthesis of 1,4-butanediamine: The invention relates to a process for biochemical synthesis of 1,4-butanediamine in a microorganism having an increased level of an ornithine decarboxylase activity (increased ODC activity) as compared to the native level of the ornithine decarboxylase activity, wherein in the microorganism also an increased activity of N-acetylglutamate formation is present... Agent: Nixon & Vanderhye, PC

20090011480 - Use of cellulosic materials for cultivation of microorganisms: The invention provides methods of cultivating oil-bearing microbes using cellulosic material. Also provided are microorganisms that manufacture non-alcohol-based fuels and fuel feedstocks through a process of converting cellulosic materials into oils. Also provided are compositions comprising depolymerized cellulosic materials and oil-bearing microbes. Some methods of microbial fermentation are provided that... Agent: Townsend And Townsend And Crew, LLP

20090011482 - Process for producing glycolic acid from formaldehyde and hydrogen cyanide: A process is provided for producing glycolic acid from formaldehyde and hydrogen cyanide. More specifically, heat-treated formaldehyde and hydrogen cyanide are reacted to produce glycolonitrile having low concentrations of impurities. The glycolonitrile is subsequently converted to an aqueous solution of ammonium glycolate using an enzyme catalyst having nitrilase activity derived... Agent: Woodcock Washburn LLP

20090011483 - Process for producing glycolic acid from formaldehyde and hydrogen cyanide: A process is provided for producing glycolic acid from formaldehyde and hydrogen cyanide. More specifically, heat-treated formaldehyde and hydrogen cyanide are reacted to produce glycolonitrile having low concentrations of impurities. The glycolonitrile is subsequently converted to an aqueous solution of ammonium glycolate using an enzyme catalyst having nitrilase activity derived... Agent: Woodcock Washburn LLP

20090011484 - Concurrent saccharification and fermentation of fibrous biomass: A process for simultaneous saccharification and fermentation of a cellulosic solids fraction extracted from a lignocellulosic feedstock. The viscosity of the cellulosic solids fraction is reduced by intermixing with a liquid carbohydrate stream. A suitable liquid carbohydrate stream is a de-lignified liquids fraction that was previously separated from the solids... Agent: Fasken Martineau Dumoulin, LLP

20090011485 - Method of retrovirus storage: A method of retrovirus storage, characterized in that a retrovirus is sustained in the presence of a substance with retrovirus binding activity immobilized on a solid phase. Further, there is provided a retrovirus composition characterized in that a retrovirus in the form of binding to a substance with retrovirus binding... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20090011486 - Biodegradable elastomers: The present inventions in various aspects provide elastic polymers compositions for encapsulation of cells. In various embodiments, the polymers are formed by the reaction of a multifunctional alcohol or ether and a difunctional or higher order acid to form a pre-polymer, which is cross-linked in the presence of glycerol and... Agent: Choate, Hall & Stewart LLP

20090011488 - Methods for storing compositions useful for synthesizing nucleic acid molecules: In one aspect, the present invention provides methods for storing a composition useful for synthesizing nucleic acid molecules. The methods of this aspect of the invention include the steps of: (a) freezing multiple aliquots of a liquid composition comprising from 1000 units/mL to 5000 units/mL of a reverse transcriptase, or... Agent: Christensen, O'connor, Johnson, Kindness, PLLC

20090011487 - Production of ugppase: What are disclosed are a purified novel enzyme protein, UGPPase, which naturally occurs in animal cells, its production by means of recombinant technology, an antibody to the enzyme protein, a method of carrying out ELISA for measurement of the amount of UGPPase in an analyte and a method for determination... Agent: Millen, White, Zelano & Branigan, P.C.

20090011489 - Multiply-substituted protease variants: Novel enzyme variants including protease variants derived from the DNA sequences of naturally-occurring or recombinant non-human proteases are disclosed. The variant proteases, in general are obtained by in vitro modification of a precursor DNA sequence encoding the naturally-occurring or recombinant protease to generate the substitution of a plurality of amino... Agent: Genencor International, Inc. Attention: Legal Department

20090011490 - Immunogenic minicells and methods of use: The disclosed invention relates to immunogenic minicells cells (anucleated) and their use to induce an immune response from a subject.... Agent: Knobbe Martens Olson & Bear LLP

20090011493 - Device containing cytophilic islands that adhere cells separated by cytophobic regions: The invention provides a device for adhering cells in a specific and predetermined position, and associated methods. The device includes a plate defining a surface and a plurality of cytophilic islands that adhere cells, isolated by cytophobic regions to which cells do not adhere, contiguous with the cytophilic islands. The... Agent: Wolf Greenfield & Sacks, P.C.

20090011494 - Method for controlling biological function with mechanical vibration and device therefor: Methods and apparatus for controlling biological functions with mechanical vibration are provided. Stimulation is applied to cells of one of an organism, bacteria or virus by mechanical vibration. The biological function comprises biological functions relating to cell growth. The biological functions relating to cell growth may include at least one... Agent: Lipsitz & Mcallister, LLC

20090011495 - Incubator apparatus and method: The present invention relates to a method of processing analyte using a portable incubator apparatus. The incubator apparatus 10 has a plurality of cavities 20 each configured to receive analyte to be incubated. The method comprises: receiving analyte in each of the plurality of cavities; incubating the analyte in the... Agent: Drinker Biddle & Reath Attn: Intellectual Property Group

20090011497 - Peptides and related compounds having thrombopoietic activity: The present invention relates generally to novel peptides and related compounds that have thrombopoietic activity. The compounds of the invention may be used to increase production of platelets or platelet precursors (e.g. megakaryocytes) in a mammal.... Agent: Amgen Inc.

20090011496 - Enhancement of mammalian embryo development: A method of enhancing in vitro development of a mammalian embryo is disclosed which comprises supplementing the culture medium with a prostaglandin, or a prostaglandin analog, in an amount effective to promote complete hatching of the embryo (i.e., freeing of the embryo from the zona pellucida). The quality of human... Agent: Conley Rose, P.C. David A. Rose

20090011499 - Antibodies that bind ldcam: The invention is directed to LDCAM as a purified and isolated protein, the DNA encoding the LDCAM, host cells transfected with cDNAs encoding LDCAM, processes for preparing LDCAM polypeptides and compositions and methods for treating utilizing LDCAM polypeptides.... Agent: Immunex Corporation Law Department

20090011504 - Cultured cell construct which contains spheroids of cultured animal cells and the use thereof: Parenchymal cells are cultivated on cultivated endothelial cells or cultivated fibroblasts which have been separated by a surface of a specific hydrophilic polymer, and which have been patterned. A culture which contains thus formed patterned spheroids of cultivated parenchymal cells is thereby provided by this invention. This culture maintains a... Agent: Wenderoth, Lind & Ponack, L.L.P.

20090011505 - Method and device for the cryo-conservation of samples: A method and a device for the cryo-conservation of a hydrous sample, in particular biological sample, wherein the sample is introduced into a cavity of a container, remaining free space of the cavity if any is filled with a hydrous liquid, the cavity is closed in a liquid-tight manner and... Agent: Alexander R Schlee SchleeIPInternational P.C.

20090011506 - Apparatus and process for washing tissue and/or cell: An apparatus for washing cells and/or tissue includes an outer sleeve, an inner assembly, and a filter. The outer sleeve includes a closed end and an open end. The inner assembly is axially movable in the outer sleeve. The filter is affixed to the inner assembly, wherein a chamber is... Agent: Quintero Law Office, PC

20090011507 - scaffolds for use in tissue engineering to culture cells: A method of creating a scaffold, for use in tissue engineering to culture cells, comprises the steps of providing a base substrate; and embroidering a plurality of interconnected stitches (12, 14, 32) in the base substrate, each stitch (12, 14, 32) being embroidered using a biocompatible thread (16). A method... Agent: Dann, Dorfman, Herrell & Skillman

20090011508 - Method for the production of a strain having a deleted region in chromosome: The present invention is related to a method for the production of a strain having a deleted region in chromosome using a transformant having an increased frequency of homologous recombination due to suppression of a Ku gene, which is a mitosporic filamentous fungus belonging to Trichocomaceae, comprising transforming said transformant... Agent: Birch Stewart Kolasch & Birch

20090011509 - Integrase fusion proteins and their use with integrating gene therapy: In a method of targeting intergration of a transgene comprising retrovirus-like DNA into a eukaryotic genome, the genome is cleared by an endonuclease and the transgene is introduced at the site of cleavage, wherein the endonuclease is specific to a site in an abundant rDNA locus and is fused to... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20090011510 - Device and method for biolistic transformation of cells: The present invention provides a device and method for biolistic bombardment of cells. In a preferred embodiment, the device comprises a hollow tube or cylinder that attaches to a standard biolistic transformation apparatus, and focuses the nucleic acids at cells and tissue sections. In a typical configuration, the device has... Agent: Latimer, Mayberry & MatthewsIPLaw, LLP

01/01/2009 > patent applications in patent subcategories.

20090004640 - Method of paraffin-penetration treatment for tissue preparation and apparatus for the treatment: The present invention provides a paraffin-penetration treatment method for a tissue preparation, which is capable of enabling sufficient penetration of paraffin even into a tissue preparation, into which paraffin can hardly penetrate by a conventional paraffin-penetration treatment method. When the penetration of the paraffin into the tissue preparation is performed... Agent: Birch Stewart Kolasch & Birch

20090004642 - In vitro method for the determination of glycemic index of food products: The present invention provides an in vitro method for determining the glycemic index values for various food products. The present invention provides an accurate and inexpensive in vitro method for determining the glycemic index of a wide variety of both food ingredients and finished food products.... Agent: Fitch Even Tabin & Flannery

20090004641 - Site-specific labeling of affinity peptides in fusion proteins: The present invention provides methods and fluorescent compounds that facilitate detecting and labeling of a fusion protein by being capable of selectively binding to an affinity tag. The fluorescent compounds have the general formula A(B)n, wherein A is a fluorophore, B is a binding domain that is a charged chemical... Agent: Invitrogen Corporation C/o Intellevate

20090004644 - Methods and compositions for processes of rapid selection and production of nucleic acid aptamers: Embodiments herein relate to compositions and methods for making and using aptamers, for example, DNA aptamers (DCEs) and/or RNA aptamers. In some embodiments, methods relate to making and amplifying target DCEs. In certain embodiments, methods for making capture elements or aptamers concern using a reporter moiety and signal reducing moiety... Agent: Faegre & Benson LLP Patent Docketing

20090004643 - Methods for concurrent identification and quantification of an unknown bioagent: The present invention provides methods for the quantification of an unknown bioagent in a sample by amplification of nucleic acid of the bioagent, and concurrent amplification of a known quantity of a calibration polynucleotide from which are obtained a bioagent identifying amplicon and a calibration amplicon. Upon molecular mass analysis,... Agent: Casimir Jones, S.c.

20090004657 - 7b2 knockout transgenic animals as models of endocrine disease: In general, the invention features methods and uses for transposon-mediated gene targeting which greatly enhance the insertion and detection of desired genes in genomic exons by homologous recombination. The invention also features transgenic non-human mammals, and eukaryotic cells, wherein a gene encoding 7B2 protein is modified, as well as nucleic... Agent: Ropes & Gray LLP

20090004649 - Everninomicin biosynthetic genes: This invention is directed to nucleic acids which encode the proteins that direct the synthesis of the orthosomycin everninomicin and to use of the nucleic acids and proteins to produce compounds exhibiting antibiotic activity based on the everninomycin structure. The DNA sequence for the gene clusters responsible for encoding everninomicin... Agent: Schering-plough Corporation Patent Department (k-6-1, 1990)

20090004662 - Method and compositions for nucleic acid amplification: The present teachings provide methods, compositions, and kits for nucleic acid amplification. In some embodiments of the present teachings, amplification reactions are performed with at least one high stability primer. In some embodiments, the present teachings provide a method comprising a high stability primer for amplification of a nucleic acid... Agent: Mila Kasan, Patent Dept. Applied Biosystems

20090004660 - Method for detecting neuroblastoma and its malignancy and method for suppressing the same: An object of the present invention is to provide a method for detecting cancer and a cell growth inhibitor through identification of genes exhibiting characteristic behavior in the cases of cancer such as neuroblastoma. The present invention provides a method for detecting cancer, which comprises detecting canceration including malignancy of... Agent: Birch Stewart Kolasch & Birch

20090004646 - Method for quantifying methylated dna: The inventive method makes it possible to quantify methylated DNA by combining the restricted digestion and real-time PCR. For this purpose, the inventive method consists in isolating the examined DNA from a biological sample, in reacting the isolated AND with a methylation specific restriction enzyme, in amplifying by means of... Agent: Kriegsman & Kriegsman

20090004666 - Method of detecting nucleotide sequence with an intramolecular probe: A nucleotide sequence-detecting method, including preparing a first intramolecular detecting sequence having a sequence complementary to a first sequence located at a 3′-side of the detecting site contained in the nucleotide sample and a second intramolecular detecting sequence having a sequence complementary to a second sequence located at a 5′-side... Agent: Scully Scott Murphy & Presser, PC

20090004661 - Method of growing mesenchymal stem cells from bone marrow: The present invention provides a method for culturing mesenchymal stem cells using cord blood serum, for therapeutic purposes in regenerative medicine; and in particular the present invention provides for the use of these cells in the treatment of PD, and the present invention has provided proliferation and neuronal differentiation of... Agent: Lackenbach Siegel, LLP

20090004647 - Method of judging grade of malignancy of carcinoma cell: Means for easily determining the grade of malignancy of cancer cells. The amount of ATBF1 in the whole cell structure of test cancer cells separated from a living organism is detected, and on the basis of detection results, the grade of malignancy of test cancer cells is judged. Alternatively, the... Agent: Kratz, Quintos & Hanson, LLP

20090004665 - Methods and compositions for isolating nucleic acid sequence variants: The invention is drawn to isolating sequence variants of a genetic locus of interest using a modified iterative primer extension method. The nucleic acids analyzed are generally single stranded and have a reference sequence which is used as a basis for performing iterative single nucleotide extension reactions from a hybridized... Agent: Bozicevic, Field & Francis LLP

20090004650 - Methods for detecting a cyclophilin b snp associated with herda: This invention provides compositions and methods for identification of carriers of Hereditary Equine Regional Dermal Asthenia (HERDA) in equine species. In particular, this invention identifies a single nucleotide polymorphorism (SNP) in cyclophlin B that can be used to identify carriers of HERDA and individuals affected by HERDA.... Agent: Townsend And Townsend And Crew, LLP

20090004652 - Methods for identifying and using snp panels: Described are methods for identifying single nucleotide polymorphism (SNPs) that are useful for analyzing genetic samples, and for using said SNPs to determine genetic identity of samples.... Agent: Fish & Richardson PC

20090004645 - Methods for identifying genes that mediate a response of a living cell to an agent: In one aspect, the present invention provides methods for determining whether a gene mediates the response of a living cell to an agent. In another aspect, the present invention provides methods to identify a mammalian subject responsive to a KSP inhibitor.... Agent: Christensen, O'connor, Johnson, Kindness, PLLC

20090004669 - Methods of diagnosing pre-eclampsia or eclampsia: Disclosed herein are methods for diagnosing pre-eclampsia and eclampsia. Also disclosed herein are methods for treating pre-eclampsia and eclampsia using compounds that increase VEGF or PlGF levels or compounds that decrease sFlt-1 levels. Compounds that inhibit the binding of VEGF or PlGF to sFlt1- are also disclosed herein for the... Agent: Clark & Elbing LLP

20090004648 - Novel nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis of ovarian cancer: Novel markers for ovarian cancer that are both sensitive and accurate. These markers are overexpressed and/or differentially expressed in ovarian cancer specifically, as opposed to normal ovarian tissue. The measurement of these markers, alone or in combination, in patient samples provides information that the diagnostician can correlate with a probable... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.c Attn: Patent Intake Customer No. 30623

20090004668 - Pre-mirna loop-modulated target regulation: By employing essential nucleotides from both the stem and loop of precursor-miRNA, greater specificity is achieved as to the mRNAs that are repressed. It is found that besides the seed sequence of the stem of the pre-miRNA, nucleotides in the loop affect the activity and specificity of the cursor- and... Agent: Robins & Pasternak

20090004659 - Probe, probe set, probe carrier, and testing method: A probe, a set of probes, and a probe carrier on which the probe or the set of probes is immobilized, are provided for classification of fungus species. The probe or the set of probes is capable of collectively detecting fungus of the same species and distinguishingly detecting those fungus... Agent: Fitzpatrick Cella Harper & Scinto

20090004663 - Real-time assays of neuro-humoral factors to assess cardiovascular stress: The present invention relates to rapid assays for neuro-humoral factors modulated in response to cardiovascular stress and integration of data obtained from such assays to provide profiles of response to cardiovascular stress that can guide therapy.... Agent: Baker Botts L.L.P.

20090004655 - Rna bioassay: The present invention relates to methods for evaluating the cell damaging potential of an agent by determining the ability of the agent to increase messenger RNA release in cells.... Agent: Pfizer Inc.

20090004651 - Screening methods for compounds that modulate the activity of g-protein coupled receptors: The present invention relates to a screening system for modulators of GPCRs. Further it relates to recombinant vector systems for the heterologous expression of heterodimeric g-protein coupled receptors (GPCRs) in eucaryotic host cells. Preferably the functional expression of engineered GPCRs for the perception of sweet and L-amino acid taste or... Agent: Propat, L.L.C.

20090004653 - Sulfonated [8,9]benzophenoxazine dyes and the use of their labelled conjugates: Fluorescent, sulfonated 3,7-diamino-[8,9]benzophenoxazine dyes are provided that are especially useful for labelling biopolymers and other substrates. The dye-labelled conjugates can be used in a variety of contexts, including cell surface assays employing intact, live cells and in nucleic acid detection methods. The new dyes are water soluble and can be... Agent: Brinks Hofer Gilson & Lione

20090004656 - Thermostable polymerases having altered fidelity and methods of identifying and using same: The present invention provides a method for identifying a thermostable polymerase having altered fidelity. The method consists of generating a random population of polymerase mutants by mutating at least one amino acid residue of a thermostable polymerase and screening the population for one or more active polymerase mutants by genetic... Agent: Nixon Peabody LLP - Patent Group

20090004672 - 17867, a novel human aminopeptidase: The present invention relates to a newly identified human aminopeptidase. The invention also relates to polynucleotides encoding the aminopeptidase. The invention further relates to methods using the aminopeptidase polypeptides and polynucleotides as a target for diagnosis and treatment in aminopeptidase-related disorders. The invention further relates to drug-screening methods using the... Agent: Banner & Witcoff, Ltd.

20090004671 - Marker protein for use in diagnosis of pancreatic cancer: Disclosed herein are a pancreatic carcinoma marker protein that is a blood protein having a molecular weight of 28,080±15, 17,272±9, 17,253±9, 8,766±5, or 14,779±8 (m/z) and a method for detecting pancreatic carcinoma using the marker protein as an indicator.... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20090004673 - Method for determining condition of disseminated intravascular coagulation: A method for determining a condition of disseminated intravascular coagulation (DIC), by analyzing the amount and/or enzyme activity of a von Willebrand factor (vWF)-cleaving protease (ADAMTS13) (preferably also the amount of vWF) in a patient suffering from DIC, and a kit for determining a condition of DIC, comprising an antibody... Agent: Heslin Rothenberg Farley & Mesiti PC

20090004674 - Acpl-related assays: The invention is directed to purified and isolated novel ACPL polypeptides, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, fragmented peptides derived from these polypeptides, and the uses of the above.... Agent: Immunex Corporation Law Department

20090004676 - T1r3 receptor binding assays for identification of taste modulatory compounds: Newly identified mammalian taste-cell-specific G protein-coupled receptors, and the genes and cDNA encoding said receptors are described. Specifically. T1R G protein-coupled receptors active in taste signaling, and the genes and cDNA encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors.... Agent: Hunton & Williams LLP Intellectual Property Department

20090004675 - Method of identifying compounds for bacterial growth modulation: The present invention relates to a method of identifying a candidate compound for modulating bacterial growth. This the method involves providing a β clamp peptide from a bacterial replicase, providing a second peptide that binds to at least one amino acid of SEQ ID NO:9 that is not designated X,... Agent: Nixon Peabody LLP - Patent Group

20090004677 - Quantitative determination of bcl10: Methods of and kits for quantitatively determining the concentrations of Bcl10 in a biological sample were developed that provide an accurate means of identifying therapeutic molecules with a plurality of therapeutic effects. A solid-phase sandwich enzyme-linked immunosorbent assay (ELISA) for human Bcl10 that provides reproducible, precise measurements was developed and... Agent: Akerman Senterfitt

20090004681 - Platelet aggregation measuring method and platelet aggregation measuring apparatus: A platelet aggregation measuring method comprising: preparing a measurement sample which contains a sample and a reagent which includes a platelet activator; mixing the measurement sample at a first speed; mixing the measurement sample at a second speed which is greater than the first speed after mixing the sample at... Agent: Sughrue Mion, PLLC

20090004683 - Indicator agent for noninflammatory stress response and use thereof: A system enabling the molecular biological visualization and quantitative detection of events in a stress-exposed living organism and a means enabling the management of stress are provided. An indicator agent for non-inflammatory stress responses mediated by superoxide, which comprises IL-18, a visualizing agent for non-inflammatory stress responses for detecting the... Agent: Wenderoth, Lind & Ponack, L.L.P.

20090004685 - Interface device and method for using the same: The present disclosure is related to an interface device for providing access to a network to be monitored. The interface device includes a plurality of elements, the elements being sensors and/or actuators. A selection means is provided for selecting a subset of elements among the plurality of elements, each element... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20090004686 - Measurement and uses of oxidative stress: The present invention provides a method of determining the overall oxidative status of a body fluid or a tissue of a patient by measuring the oxidation-reduction potential (ORP) of the body fluid or tissue. The method has been found to be useful in the diagnosis, evaluation and monitoring of patients... Agent: Sheridan Ross PC

20090004687 - Predictive markers for ovarian cancer: Methods are provided for predicting the presence, subtype and stage of ovarian cancer, as well as for assessing the therapeutic efficacy of a cancer treatment and determining whether a subject potentially is developing cancer. Associated test kits, computer and analytical systems as well as software and diagnostic models are also... Agent: Cooley Godward Kronish LLP Attn: Patent Group

20090004688 - Sampling system and method: A sampling system and method may use a kit that has a package enclosing a swab and a receptacle. The swab may have a shaft and a tip. The tip may be substantially made of calcium alginate. The receptacle may contain a diluent, such as sodium citrate, and glass beads.... Agent: Beem Patent Law Firm

20090004690 - Composition and methods for making 5, 10, 15, 20-tetrakis (carboxyphenyl) porphine: Presented is a method to detect precancerous states in mammalian cell and tissue samples comprising incubating a sample with solubilized 5, 10, 15, 20-tetrakis (carboxyphenyl)porphine (TCPP), measuring TCPP fluorescence in the sample, and categorizing the sample as non-cancerous, precancerous or cancerous based on TCPP fluorescence, as correlated with the respective... Agent: Peacock Myers, P.C.

20090004691 - Enhanced fluidic method and apparatus for automated rapid immunohistochemistry: A sample processing system that may be configured to achieve rapid sample processing such as rapid histochemical processing may involve a wave element that can use angular microscopic slide movements to cause repeated elimination and reapplication of a fluidic substance perhaps through the action of capillary motion in order to... Agent: Santangelo Law Offices, P.C.

20090004692 - Methods to enhance the activity of lignocellulose-degrading enzymes: Methods for hydrolyzing lignocellulose are provided, comprising contacting the lignocellulose with at least one chemical treatment. Methods for pretreating a lignocellulosic material comprising contacting the material with at least one chemical are also provided. Methods for liberating a substance such as an enzyme, a pharmaceutical, or a nutraceutical from plant... Agent: Alston & Bird LLP

20090004695 - Process for constructing strain having compactin hydroxylation ability: The present invention is directed to methods and compositions for microbial based production of pravastatin. The compositions of the invention include novel strains of microorganisms that are capable of efficiently hydroxylating compactin (ML-236 B) resulting in production of pravastatin. In particular, the microorganisms of the invention are genetically engineered to... Agent: Kenyon & Kenyon LLP

20090004693 - Production of polypeptides by improved secretion: The present invention relates to polypeptides that have an activity corresponding to at least one activity of the SEC61 polypeptide, polynucleotides encoding these polypeptides and the use thereof in the preparation of host cells suitable for production of a polypeptide of interest. Such host cells may have an increased capacity... Agent: Nixon & Vanderhye, PC

20090004697 - Generation of chemical building blocks from plant biomass by selective depolymerization: The invention concerns a method for the enzymatic treatment of raw polymeric feedstock comprising the following steps: (a) preferably separation of soluble components from the raw polymeric feedstock, (b) treating the raw polymeric feedstock with an enzyme system in order to liberate defined soluble monomeric or oligomeric building blocks from... Agent: Sterne, Kessler, Goldstein & Fox P.l.l.c.

20090004698 - Methods to enhance the activity of lignocellulose-degrading enzymes: Methods for hydrolyzing lignocellulose are provided, comprising contacting the lignocellulose with at least one chemical treatment. Methods for pretreating a lignocellulosic material comprising contacting the material with at least one chemical are also provided. Methods for liberating a substance such as an enzyme, a pharmaceutical, or a nutraceutical from plant... Agent: Alston & Bird LLP

20090004699 - Process for producing beta-chitin: The method of the present invention for producing β-chitin comprises a step of cultivating an alga capable of producing β-chitin using a medium that contains nitrogen (N), phosphorus (P), silicon (Si), and selenium (Se), wherein the weight ratio of phosphorus to nitrogen (P/N) is 0.1 or above, the weight ratio... Agent: Mcleland Patent Law Office, P.l.l.c.

20090004700 - Chemical induction in quiescence in bacteria: Quiescence is induced in cells using indole compounds. Expression continues from extra-chromosomal vectors within the cells during quiescence, while chromosomal expression is suppressed. The cells may be used as factories for the production of large amounts of polypeptides of interest, particularly polypeptides which normally have an adverse effect on cell... Agent: Klarquist Sparkman, LLP

20090004702 - Codon specific mutagenesis: Materials and Methods are provided for replacing one or more amino acids in a polypeptide with an amino acid of choice to form mutant proteins. Both naturally and non-naturally occurring amino acids can be inserted. A population of mutant proteins can be created in which an amino acid residue has... Agent: Arent Fox LLP

20090004701 - Multiplex oligonucleotide addition and target amplification: Methods for appending oligonucleotides directly to nucleic acid templates, particularly to defined sites internal to single-stranded templates, are described. Appending first and second common priming sites to each of a plurality of templates of distinct sequence allows the subsequent stoichiometric amplification of a plurality of templates of distinct sequence.... Agent: Affymetrix, Inc Attn: ChiefIPCounsel, Legal Dept.

20090004706 - Methods to enhance the activity of lignocellulose-degrading enzymes: Methods for hydrolyzing lignocellulose are provided, comprising contacting the lignocellulose with at least one chemical treatment. Methods for pretreating a lignocellulosic material comprising contacting the material with at least one chemical are also provided. Methods for liberating a substance such as an enzyme, a pharmaceutical, or a nutraceutical from plant... Agent: Alston & Bird LLP

20090004707 - Process for producing glycolic acid from formaldehyde and hydrogen cyanide: A process is provided for producing glycolic acid from formaldehyde and hydrogen cyanide. More specifically, heat-treated formaldehyde and hydrogen cyanide are reacted to produce glycolonitrile having low concentrations of impurities. The glycolonitrile is subsequently converted to an aqueous solution of ammonium glycolate using an enzyme catalyst having nitrilase activity derived... Agent: Woodcock Washburn LLP

20090004708 - Process for producing glycolic acid from formaldehyde and hydrogen cyanide: A process is provided for producing glycolic acid from formaldehyde and hydrogen cyanide. More specifically, heat-treated formaldehyde and hydrogen cyanide are reacted to produce glycolonitrile having low concentrations of impurities. The glycolonitrile is subsequently converted to an aqueous solution of ammonium glycolate using an enzyme catalyst having nitrilase activity derived... Agent: Woodcock Washburn LLP

20090004709 - Process for producing glycolic acid from formaldehyde and hydrogen cyanide: A process is provided for producing glycolic acid from formaldehyde and hydrogen cyanide. More specifically, heat-treated formaldehyde and hydrogen cyanide are reacted to produce glycolonitrile having low concentrations of impurities. The glycolonitrile is subsequently converted to an aqueous solution of ammonium glycolate using an enzyme catalyst having nitrilase activity derived... Agent: Woodcock Washburn LLP

20090004710 - Process for producing glycolic acid from formaldehyde and hydrogen cyanide: A process is provided for producing glycolic acid from formaldehyde and hydrogen cyanide. More specifically, heat-treated formaldehyde and hydrogen cyanide are reacted to produce glycolonitrile having low concentrations of impurities. The glycolonitrile is subsequently converted to an aqueous solution of ammonium glycolate using an enzyme catalyst having nitrilase activity derived... Agent: Woodcock Washburn LLP

20090004711 - Process for producing glycolic acid from formaldehyde and hydrogen cyanide: A process is provided for producing glycolic acid from formaldehyde and hydrogen cyanide. More specifically, heat-treated formaldehyde and hydrogen cyanide are reacted to produce glycolonitrile having low concentrations of impurities. The glycolonitrile is subsequently converted to an aqueous solution of ammonium glycolate using an enzyme catalyst having nitrilase activity derived... Agent: Woodcock Washburn LLP

20090004712 - Drying apparatus and methods for ethanol production: The apparatus and methods disclosed herein relate to the production of dried co-products from stillage produced by an ethanol production facility. In various aspects, the apparatus and methods disclosed herein relate to an ethanol production facility that produces ethanol and stillage from grain, and a pulse combustion dryer in communication... Agent: Cyr & Associates, P.A.

20090004714 - Non-pressurised pre-treatment, enzymatic hydrolysis and frementation of waste fractions: The present invention relates to a process for production of fermentation products, including bioethanol by non-pressurised pre-treatment, enzymatic hydrolysis and fermentation of waste fractions containing mono- and/or polysaccharides, having a relatively high dry matter content. The process in its entirety, i.e. from non-pressurised pre-treatment over enzymatic hydrolysis and fermentation to... Agent: Budde, Schou & Ostenfeld, A/s

20090004715 - Glycerol feedstock utilization for oil-based fuel manufacturing: The invention provides methods of manufacturing biodiesel and other oil-based compounds using glycerol and combinations of glycerol and other feedstocks as an energy source in fermentation of oil-bearing microorganisms. Methods disclosed herein include processes for manufacturing high nutrition edible oils from non-food feedstock materials such as waste products from industrial... Agent: Townsend And Townsend And Crew, LLP

20090004719 - Protein-protein interactions in human immunodeficiency virus: The present invention relates to protein-protein interactions involved in AIDS. More specifically, the present invention relates to complexes of polypeptides or polynucleotides encoding the polypeptides, fragments of the polypeptides, antibodies to the complexes, Selected Interacting Domains (SID®) which are identified due to the protein-protein interactions, methods for screening drugs for... Agent: Lerner, David, Littenberg, Krumholz & Mentlik

20090004720 - Smart biocatalysts for organic synthesis: The present disclosure relates to compositions, systems, and methods that include a reusable biocatalyst. A reusable biocatalytic composition may include a stimulus-responsive support operable to be soluble under at least one first condition and insoluble under at least one second condition; and a biocatalyst bound to the stimulus-responsive support complex.... Agent: Baker Botts L.L.P.

20090004721 - Dengue virus mutant strain mbu 01-2002: The invention includes a genetic construct and a mutant dengue virus, designated as strain MBU 01-2002, which is a mutant dengue virus generated by genetic modification of the 13-amino acid sequence just proximal to the pr-M junction within the prM coding region of the genome. The modification involves increasing the... Agent: Ms. Nuttina Netsuwan

20090004723 - Methods and compositions concerning poxviruses and cancer: The present invention concerns methods and compositions for the treatment of cancer and cancer cells using altered poxviruses, including a vaccinia virus that has been altered to generate a more effective therapeutic agent. Such poxviruses are engineered to be attenuated or weakened in their ability to affect normal cells. In... Agent: Fulbright & Jaworski L.L.P.

20090004724 - Method for enhancing production of isoprenoid compounds: The present invention provides methods of producing an isoprenoid or an isoprenoid precursor in a genetically modified host cell. The methods generally involve modulating the level of hydroxymethylglutaryl-CoA (HMG-CoA) in the cell, such that the level of HMG-CoA is not toxic to the cell and/or does not substantially inhibit cell... Agent: Bozicevic, Field & Francis LLP

20090004728 - Method of biotreatment for solid materials in a nonstirred surface bioreactor: A method of biotreating a solid material to remove an undesired compound using a nonstirred surface bioreactor is provided. According to the method, the surface of a plurality of coarse substrates is coated with a solid material to be biotreated to form a plurality of coated coarse substrates. The coarse... Agent: Jones Day

20090004729 - Reaction device: A reaction device including: a plurality of reaction areas; and a plurality of heating parts configured to be each provided for a respective one of the reaction areas, wherein each of the heating parts includes: a heat source; a scan line for selecting the heating part; a data line that... Agent: Bell, Boyd & Lloyd, LLP

20090004730 - Cell obsevation aiding instrument and method of cell observation therewith: A cell observation support instrument having opposed first and second surface members 115 and 117 and stoppers that are positioned between the first and second surface members 115 and 117 in order to prevent movement of cells. The first and second surface members 115 and 117 form a cell-containing space... Agent: Antonelli, Terry, Stout & Kraus, LLP

20090004731 - Cell culture apparatus and a fabricating method of the same: A cell culture apparatus and a method for fabricating the cell culture apparatus are disclosed, the method comprises forming at least one fillister on a biomaterial composite layer by photolithography, wherein the biomaterial composite layer contains two gel materials. One is a bio-compatible hydrogel composition having various weight ratio of:... Agent: Bacon & Thomas, PLLC

20090004739 - Efficient method of preparing dna inverted repeat: In this invention, a cassette construct comprising an arbitrary adaptor sequence and an inverted adaptor sequence separated by an arbitrary spacer sequence or a plasmid vector comprising such cassette construct incorporated therein is prepared, a target sequence is ligated to either or both ends of the cassette construct, or a... Agent: Greenblum & Bernstein, P.L.C

20090004741 - Biodegradable polyphosphoramidates for controlled release of bioactive substances: The present invention is directed to a series of new polycationic biodegradable polyphosphoramidates. Process for making the polymers, compositions containing these polymers and bioactive ligands to enhance the cellular uptake ad intracellular trafficking, articles and methods for delivery of drugs and genes using these polymers are described. A gene delivery... Agent: Greenberg Traurig LLP (la)

20090004740 - Primate totipotent and pluripotent stem cells produced by somatic cell nuclear transfer: Purified totipotent stem cells and pluripotent stems cells derived by somatic cell nuclear transfer are disclosed herein, as well as cell lines, multipotent cells and differentiated cells produced from these stem cells. The stem cells are produced from an enucleated host cell from a first donor and nuclear genetic material... Agent: Klarquist Sparkman, LLP

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