"That makes life difficult for opponents and opens up space for team-mates. Pato is an ideal choice to play alongside both of those players. Every time he is on the pitch with one of those two, we score goals."

Group Two rivals Corinthians and San Lorenzo are not in action during the week.

Brazilian Serie A champions and last season's quarter-finalists Cruzeiro kick-off their Group Three campaign in Bolivia on Wednesday.

Cruzeiro, who were eliminated by San Lorenzo last season, take on Club Universitario at Estadio Olimpico Patria.

Copa Argentina winners Huracan and Venezuelan outfit Mineros de Guayana also take to the field for the first time in Group Three on Tuesday, with the two teams meeting in Buenos Aires.

Former Porto and Lyon striker Lisandro Lopez could make his bow for Internacional against Universidad Chile in Group Four on Tuesday after signing a pre-contract.

Internacional will be hoping Lopez faces the Chileans following last week's 3-1 loss to The Strongest.

Emelec and The Strongest go head-to-head in Ecuador on Tuesday.

In Group Five, Boca Juniors host Wanderers on Thursday after both teams won their opening matches.

Zamora and Palestino are in action on the same day.

There is only one match in Group Seven, with Barcelona opening their campaign at home to Estudiantes.

Group Eight leaders Racing Club are at home to Guarani on Tuesday, while Deportivo Tachira travel to Sporting Cristal on Thursday.

Colo Colo and Santa Fe, who were both victorious last week, will clash in Group One on Thursday.

Atletico Mineiro - aiming to bounce back from their 2-0 loss against Colo Colo - entertain Atlas on Wednesday.