LCHF

Topics

NCBI 2016: Antibiotics in the first year of life and subsequent neurocognitive outcomes. Those who had received antibiotics had more behavioural difficulties and more symptoms of depression at follow up.

Because of the rapid rate of growth and metabolic rate during the first two years of life, nutrient needs per unit body weight of infants and young children are very high. Given the relatively small amounts of foods that are consumed at 6-24 months, the nutrient density (amount of each nutrient per 100 kcal of food) of the diet needs to be very high. ... The results indicated that a diet based predominantly on unfortified plant-based foods cannot meet the needs for certain micronutrients at this age, particularly iron, zinc,calcium and vitamin B12. Therefore, it is advisable to include milk products, as well as meat, poultry, fish or eggs, as often as possible.

Redox Biology Apr. 2015: We have provided data on NLRP3, as a critical regulator, involved in the pathogenesis of obesity, type 2 diabetes and cardiovascular diseases.

Eur J Intern Med Apr 2011: Nutrition and Alzheimer's disease: the detrimental role of a high carbohydrate diet.

In this paper, we highlight how an excess of dietary carbohydrates, particularly fructose, alongside a relative deficiency in dietary fats and cholesterol, may lead to the development of Alzheimer's disease. A first step in the pathophysiology of the disease is represented by advanced glycation end-products in crucial plasma proteins concerned with fat, cholesterol, and oxygen transport. This leads to cholesterol deficiency in neurons, which significantly impairs their ability to function. Over time, a cascade response leads to impaired glutamate signaling, increased oxidative damage, mitochondrial and lysosomal dysfunction, increased risk to microbial infection, and, ultimately, apoptosis. Other neurodegenerative diseases share many properties with Alzheimer's disease, and may also be due in large part to this same underlying cause.

Currently, there is a rapid growth in the literature pointing toward insulin deficiency and insulin resistance as mediators of AD-type neurodegeneration, but this surge of new information is riddled with conflicting and unresolved concepts regarding the potential contributions of type 2 diabetes mellitus (T2DM), metabolic syndrome, and obesity to AD pathogenesis. Herein, we review the evidence [... ] We conclude that the term “type 3 diabetes” accurately reflects the fact that AD represents a form of diabetes that selectively involves the brain and has molecular and biochemical features that overlap with both type 1 diabetes mellitus and T2DM.

Even more concerning is that evidence for the benefit in the advocated target levels of salt intake is virtually absent; there are no RCTs measuring health outcomes when sodium intake is less than 2·3 g (5 g of salt).