Figure 5.

Using Firegoose to investigate transcription response of H. salinarum to anoxic conditions. A list of genes with similar expression profiles is found by microarray analysis.
(1) We broadcast these genes to KEGG to query for known biochemical pathways, for
example, viewing the Arginine and proline metabolism pathway. (2) We broadcast the
genes to EMBL STRING, a protein interaction database, where we can (3) navigate to
functionally related genes. (4) In order to manipulate the network, we broadcast it
to Cytoscape. (5) A local database provides additional information. (6) DAVID performs
functional clustering. (7) For one cluster containing signal transduction genes, we
use String's links to protein domains.