Predictors of Treatment Outcome with Cognitive Behavioral Therapy for Depression

Purpose of Study: The purpose of this research study is to learn whether specific types of brain imaging and psychological testing can predict how much benefit patients with depression will receive from a well-studied psychotherapy for depression, called cognitive behavioral therapy (CBT), and how the brain imaging and psychological tests change with treatment. We will also be comparing brain scans from this study between individuals suffering from depression and volunteers without depression.

Eligibility: Must be 18-65 years old. Recruiting for both individuals suffering from depression as well as volunteers without depression. Volunteers without depression will complete brain imaging, but will not receive psychotherapy.