M. Jackson Stutts, PhD

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M. Jackson Stutts, PhD, Professor of Medicine

We have long known that ENaC mediated Na+ absorption by airway epithelia of CF patients is elevated. Our lab and colleagues recently documented that the absence of functional CFTR causes abnormal stimulation of ENaC by cAMP and excessive proteolytic activation of ENaC. Presently, we are designing experiments to test the possibility that these deranged ENaC regulatory pathways are connected.