HONG, HAO

Professor HONG’s research focuses on the molecular targets of Alzheimer's disease and related diseases (such as depression and diabetes) using the methods of molecular biology and genetic.Recently, he found that cysteinyl leukotriene receptor 1 (CysLT1R) is involved in Aβ-inducedneurotoxicity and CysLT1R antagonist ameliorates Aβ-induced impairment of hippocampus plasticity and neuroinflammatory and apoptotic responses. He also found that abnormal transport of Aβacross the BBB is an important initiating factor in diabetes-associated cognitive decline, and rectifying the abnormalAβ transport across the BBB is an important strategy for prevention and treatment of diabetes-associated cognitive decline. His latest research shows that Hippocampal PPARδ regulates stress-induced depressive behaviors and neurogenesis arrest.

Current Grants

The role of Cysteinyl Leukotriene Receptor 1 in Alzheimer’s Disease and Underlying Mechanisms

Principal Investigator: HONG HAO

Agency: NSF C, No. 81573413

Dates: 01/2016-12/2019

The role of abnormal transport of β amyloid protein across the blood-brain barrier in cognitive dysfunction of diabetes mellitus

Principal Investigator: HONG HAO

Agency: NSF C, No. 81273497

Dates: 01/2013-12/2016

3. PPARδ as a potential antidepressant target and its underlying mechanism

Principal Investigator: HONG HAO

Agency: NSFJS, No. BK20131307

Dates: 06/ 2013-06/2016

Education

2005-2006Visiting Scholar in Pathological Physiology, Kinki

University (Japan)

2001-2004Ph.D. in Pharmacology, China Pharmaceutical

University

1998-2001M.S. in Medicine, Anhui University of Traditional Chinese Medicine