3Gladstone Institute for Cardiovascular Disease, 4Department of Medicine, and 5Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 941583Gladstone Institute for Cardiovascular Disease, 4Department of Medicine, and 5Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 941583Gladstone Institute for Cardiovascular Disease, 4Department of Medicine, and 5Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158