His history is uncertain but based on the chronicles his life can be calculated.[citation needed] He was born circa 72 and died in 114. Details are different between the two books, and the version in Kojiki is assumed to be loyal to the older form of this legend.

Prince Ōsu slew his elder brother Ōusu (大碓命, おおうすのみこと). His father, the emperor Keikō, feared his brutal temperament. To keep him at a distance, the father sent him to Izumo Province, today the eastern part of Shimane Prefecture, and then the land of Kumaso, today Kumamoto Prefecture. However, Ōsu succeeded in defeating his enemies, in the latter case by cross-dressing as a maid attendant at a drinking party (see image left). One of the enemies he defeated praised him and gave him the title Yamatotakeru, meaning The Brave of Yamato. But Emperor Keikō's mind was unchanged.

Keikō sent Yamato Takeru to the eastern land whose people disobeyed the imperial court. Yamatotakeru met his aunt Princess Yamato-hime, the highest priestess of Amaterasu at Ise Grand Shrine (in Ise Province) and grieved, "my father wishes I would die?" Princess Yamato-hime showed him compassion and lent him a holy sword named Ame no Murakumo no tsurugi (Kusanagi no tsurugi), which Susanoo, the brother god of Amaterasu, found in the body of the eight-headed great serpent, Yamata no Orochi. Yamatotakeru went to the eastern land. He lost his wife Oto tachibana-hime during a storm when she sacrificed herself to soothe the anger of the sea god. He defeated many enemies in the eastern land, and legend has it that he and a local old man composed the first sedōka in Kai Province with Mount Tsukuba (now in Ibaraki Prefecture) as its theme. On his return he blasphemed a local god of Mount Ibuki, which sits on the border of Ōmi Province and Mino Province. The god cursed him with disease and he fell ill.

The story above is found in the Kojiki. In the Nihonshoki version, the father and Yamatotakeru keep a good relation.

According to traditional sources, Yamato Takeru died in the 43rd year of Emperor Keiko's reign (景行天皇43年).[1] The possessions of the dead prince were gathered together along with the sword Kusanagi; and his widow venerated his memory in a shrine at her home. Some time later, these relics and the sacred sword were moved to the current location of Atsuta Shrine.[2]

The statue of Yamato Takeru at Kenroku-en

Yamato Takeru is believed to have died somewhere in Ise Province. According to the legend, the name of Mie Prefecture was derived from his final words. After death his soul turned into a great white bird and flew away. His tomb in Ise is known as the Mausoleum of the White Plover. A statue of Yamato Takeru stands in Kenroku-en in Kanazawa, Ishikawa.

Anthropologist C. Scott Littleton has described the Yamato Takeru legend as “Arthurian”[3] due to some structural similarities with the King Arthur legend. Common points include the use of two magic swords, of which the first validates the authority of the hero; the leadership role of a war band; the death to an enemy after giving up the sword to a female figure; a transportation to the afterworld; and others.[4] Littleton proposed that both legends descend from a common northeast Iranian ancestor.[5]

Yamato Takeru is featured as a starring character in the 1990s cult hit anime Garzey's Wing as Yamato Takeru no Mikoto. Yamato Takeru no Mikoto is a beloved hero of Chris and helps him with his Yamato Takeru no Mikoto Shrine to find Garzey's Wing.

The story of Yamato Takeru was turned into a live action movie loosely based on this prince. However, it was a fantasy/sci-fi movie about magic, monsters, love, and mecha. Just like the legend, he was famous for being a warrior and given the title "Yamatotakeru," but the main focus of the plot was to defeat the Yamata no Orochi.

Yamato Takeru was featured as an anime series about a boy living amongst human-like aliens and acquired a powerful robot with a sword.

The third volume of Osamu Tezuka's Phoenix series features a somewhat de-mythologized version of Yamato Takeru as its protagonist but, aside from his adventure in Kumaso, the book's story bears little resemblance to the original legend.

In the video game Persona 4, Naoto Shirogane's ultimate Persona is Yamato Takeru.

The second book of Noriko Ogiwara's The Jade Trilogy, "Mirror Sword and Shadow Prince," is a retelling of Yamato Takeru's legend. The novel follows Oguna, a.k.a. Prince Ousu, one of the two main protagonists.

In the anime and manga Eyeshield 21, the real Eyeshield 21 is Yamato Takeru, the running back of the Teikoku Alexanders.

In the anime Digimon Adventure, (Digimon: Digital Monsters outside of Japan) two of the main characters are originally named Yamato and Takeru, both being brothers.

In the mobile game Puzzles and Dragons, Yamato is featured as a playable god as of late 2013.

"The Assassins", the very first scenario (level) of the Yamato Campaign of the game Age of Empires is problably based in Takeru's raid against the Izumo. He is possibly represented there by the "Hero Perseus" character, an archer with Japanese-like clothes and the most powerful unit controlled by the player.

Yamato Takeru is seen in a dream in the epilogue to "The Golden Princess", one of the Novels of the Change. The sword itself is the major plot point.