Krabbe's disease is a degenerative neurological disorder with rapidly progressive demyelination of the central and peripheral nervous systems. It is a lysosomal storage disease that results from an autosomal recessive mutation in the...

As a novel therapy for neurodegenerative diseases, transplantation of multipotent mesenchymal stromal cells (MSCs) requires extensive optimization in animal models before being implemented in clinical trials. It is a goal of our laboratory to...

The twitcher mouse is an animal model of Krabbe's disease which is a neurodegenerative lysosomal storage disorder resulting from the absence of functional lysosomal enzyme galactocerebrosidase (GALC). This disease affects the central and peripheral...