Brief description of study

The aim of this study is to describe the natural history of patients with alpha-1
antitrypsin associated emphysema and to figure out associated prognostic factors.

Detailed Study Description

All patients who suffer from this disease are followed every 6 months during a 5 years
period. FEV1 decline is the primary endpoint. Quality of life assessed using the Saint
George's Respiratory Questionary is recorded too.