Mechanisms of antibiotic resistance

4.11 - 1251 ratings - Source

Antibiotics represent one of the most successful forms of therapy in medicine. But the efficiency of antibiotics is compromised by the growing number of antibiotic-resistant pathogens. Antibiotic resistance, which is implicated in elevated morbidity and mortality rates as well as in the increased treatment costs, is considered to be one of the major global public health threats (www.who.int/drugresistance/en/) and the magnitude of the problem recently prompted a number of international and national bodies to take actions to protect the public (http://ec.europa.eu/dgs/health_consumer/docs/road-map-amr_en.pdf: http://www.who.int/drugresistance/amr_global_action_plan/en/; http://www.whitehouse.gov/sites/default/files/docs/carb_national_strategy.pdf). Understanding the mechanisms by which bacteria successfully defend themselves against the antibiotic assault represent the main theme of this eBook published as a Research Topic in Frontiers in Microbiology, section of Antimicrobials, Resistance, and Chemotherapy. The articles in the eBook update the reader on various aspects and mechanisms of antibiotic resistance. A better understanding of these mechanisms should facilitate the development of means to potentiate the efficacy and increase the lifespan of antibiotics while minimizing the emergence of antibiotic resistance among pathogens.Jun Lin, Kunihiko Nishino, Marilyn C. Roberts, Marcelo Tolmasky, Rustam I.
Aminov, Lixin Zhang ... Tertiarytreated is a significant point source of municipal
wastewater antibiotic resistance genes into Duluth-Superior Harbor. ... Cloning: A
Laboratory Manual. ... Tchobanoglous, G., Burton, F. L., and Stensel, H. D. (2003)
. ... This is an open-access article distributed under the terms of the Creative
Commons Attribution License, which permits use, distribution and reproduction in
otheranbsp;...