In one study restrictive cardiomyopathy induced by chloroquine was diagnosed by non-invasive methods jugular venous pulse and cross-sectional echocardiography and skeletal muscle biopsy, revealing curvilinear and myelinoid bodies.2 Five weeks after discontinuation of chloroquine, the patient expired and post-mortem EM of the cardiac tissue revealed myelinoid and curvilinear bodies. Chloroquine-induced itching is very common among black Africans 70%, but much less common in other races. It increases with age, and is so severe as to stop compliance with drug therapy. It is increased during malaria fever; its severity is correlated to the malaria parasite load in blood. Apr 09, 1977 1. Br Med J. 1977 Apr 9;16066945-6. Chloroquine induced involuntary movements. Umez-Eronini EM, Eronini EA. PMCID PMC1605758 PMID 851793

Ry Rs are especially important in neurons and muscle cells. It has been shown that calcium release from a number of ryanodine receptors in a ryanodine receptor cluster results in a spatiotemporally restricted rise in cytosolic calcium that can be visualised as a calcium spark.

Chloroquine-induced em

Chloroquine-induced pruritus has been described as a ‘biting’ or stinging sensation which occurs after some hours of chloroquine administration irrespective of the route of administration.

Chloroquine-induced pruritus.

Chloroquine induced involuntary movements..

Chloroquine activates the p53 pathway and induces apoptosis..

While chloroquine induced very little apoptosis alone or in combination with the AKT inhibitors, when combined with gefitinib, apoptosis levels were increased in PC-9 cells Fig. Fig.6A. 6A. Notably, when chloroquine, gefitinib, and an AKT inhibitor were all combined, apoptosis was further enhanced. Ryanodine receptors RyRs form a class of intracellular calcium channels in various forms of excitable animal tissue like muscles and neurons. There are three major isoforms of the ryanodine receptor, which are found in different tissues and participate in different signaling pathways involving calcium release from intracellular organelles. Characterization of a chloroquine‐induced canine model of pruritus and skin inflammation Amanda Blubaugh Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, 2200 College Station Road, Athens, GA, 30602 USA

Applies to hydroxychloroquine: oral tablet Along with its needed effects, hydroxychloroquine may cause some unwanted effects. Hydroxychloroquine Side Effects Common, Severe, Long Term. Plaquenil - FDA prescribing information, side effects and uses Plaquenil Side Effects on Your Eyes and Vision

Chloroquine has long been used in the treatment or prevention of malaria from Plasmodium vivax, P. malariae, excluding the malaria parasite Plasmodium falciparum, for it started to develop widespread resistance to it. Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance.

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Chloroquine - LiverTox - NCBI Bookshelf Chloroquine is an aminoquinoline used for the prevention and therapy of malaria. It is also effective in extraintestinal amebiasis and as an antiinflammatory agent for therapy of rheumatoid arthritis and lupus erythematosus.