Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

Suitable for use in Western Blot, Immunoprecipitation and Immunohistochemistry. Western Blot Analysis: 1:5000-1:10000 dilution of this lot detected BRCA1 in HeLa nuclear extract. Immunohistochemistry: This antibody has been reported by an independent laboratory to detect BRCA1 in breast cancer tumor sections. Immunoprecipitation: This antibody has been reported by an independent laboratory to immunoprecipitate BRCA1.

Description: E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function.