Abstract:Two models for in-vitro avascular tumor growth are discussed which are
complementary with respect to the growth stages they model.
One of the models is a single-cell-based off-lattice model (in three dimensions),
the other is a lattice approach (in two dimensions).
The off-lattice approach operates in an early tumor growth stage where no
growth-limitation due to a lack of nutrient occurs,
whereas the lattice approach focuses on a
later stage where nutrients are already lacking inside the tumor such that a
necrotic core is formed.
Chemicals released by dying cells at the later stage induce a cell migration
toward the necrotic core which eventually is found to limit further growth.
By combining the results of both models a potential qualitative scenario of
avascular tumor growth is discussed.