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Description

Overview

Irreversible inhibitor of serine proteases. Its mechanism of action is analogous to that of diisopropylfluorophosphate. PMSF causes sulfonylation of the active-site serine residues. Also reported to inhibit internucleosomal DNA fragmentation in immature thymocytes. For a related, more stable inhibitor, see AEBSF (Cat. No. 101500).

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Product Usage Statements

Storage and Shipping Information

Ship Code

Ambient Temperature Only

Toxicity

Corrosive

Hazardous Materials Attention:

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Storage

+15°C to +30°C

Protect from Moisture

Protect from moisture

Do not freeze

Ok to freeze

Special Instructions

Following reconstitution, refrigerate (4°C). Stock solutions are stable for up to 9 months at 4°C.

Citations

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision

19-August-2008 RFH

Synonyms

Benzylsulfonyl Fluoride, PMSF

Description

Irreversible inhibitor of serine proteases. Its mechanism of action is analogous to that of diisopropylfluorophosphate. PMSF causes sulfonylation of the active-site serine residues. Also reported to inhibit internucleosomal DNA fragmentation in immature thymocytes. Effective at a concentration of 50 µM.

Form

White to off-white crystalline solid

CAS number

329-98-6

RTECS

XT8040000

Chemical formula

C₇H₇FO₂S

Structure formula

Purity

≥99% by GC

Solubility

Ethanol, isopropanol, or methanol

Storage

+15°C to +30°C
Protect from moisture

Do Not Freeze

Ok to freeze

Special Instructions

Following reconstitution, refrigerate (4°C). Stock solutions are stable for up to 9 months at 4°C.