In order to improve the accuracy of prediction of water inflow in mines in the Binchang mining area, the Luohe formation can be divided into the upper and lower aquifers based on hydrogeological supplementary exploration. A hydrogeological conceptual model of drainage to a river considering the vertical seepage for prediction of stratified water inflow of a giant thick aquifer, called “the model of aquifer water inflow to the working face”, is established. The prediction method combining the mine excavation plan and considering the release of the static reserves, the dynamic recharge and the vertical seepage of the aquifer, called “the prediction method of water inflow combining dynamic recharge and release of static reserves”, is given. As an examples, the maximum water inflow of the 101 working face of the Gaojiabu coal mine is predicted to be 1 222.11 m3/h, and the stable inflow in the early post-harvest period is 950.07 m3/h. The maximum water inflow of the 201 working face of the Gaojiabu coal mine is predicted to be 610.93 m3/h, and the stable inflow in the early post-harvest period is 536.73 m3/h. Compared with the real inflow, the accuracy of inflow prediction results are greatly improved, with the absolute error of inflow predicted of -130.49~20.64 m3/h and the error rate of -21.05%~8.39%.