MECHANISM OF ACTION

PROTECTION OF CARTILAGE

Intra-articularly injected NOLTREX™ covers the entire joint surfaces and the synovial lining with a uniform layer of lubricating gel. The hydrogel layer creates a shock-absorbing effect, cushions the mechanical load on the joint, which helps to preserve the integrity of cartilage/stop further destruction of the cartilage.

PHYSICAL SEPARATION OF FRICTIONING SURFACES

Due to synovial viscosupplementation the joint space widens, i.e. the contacting and frictioning surfaces of the affected joint are physically separated. Thus, due to the reduced friction a mechanical protection of articular cartilages is achieved; the irritant constantly present in the joint, typically leading to pain and inflammation, is eliminated.

SYNOVIAL VISCOSUPPLEMENTATION OF JOINTS

When injected in the joint affected by osteoarthritis, NOLTREX™ substitutes for compromised synovial fluid. This does not lead to the formation of any new chemical molecules, does not alter the biologic interaction of the synovial fluid or mediate a bodily response. Reduction of pain and inflammation are secondary effects resulting from improved joint lubrication.