Take 1 tablet as needed. Do not exceed 3 tablets daily. Do no take within 5 hours of bedtime.

Warnings:

THIS PRODUCT IS ONLY INTENDED FOR HEALTHY ADULTS, 18 YEARS OF AGE OR OLDER. Do not use if pregnant, nursing, prone to dehydration or exposed to excessive heat. Before using this product, consult a licensed, qualified health care professional if you are unaware of your current health condition, or if you have been treated for, diagnosed with or have a family history of any medical condition, including but not limited to: high or low blood pressure, diabetes, anxiety, cardiovascular, psychiatric or seizure disorders, cardiac arrhythmia, stroke, heart, liver, kidney or thyroid disease, or difficulty urinating duet to prostate enlargement, or if you are taking any other prescription or over-the-counter medication. This product should not be used in combination with caffeine or stimulants from other sources, including but not limited to: coffee, tea, soda, other dietary supplements and medications. Too much caffeine may cause nervousness, irritability, sleeplessness, and rapid heart rate. Immediately discontinue use and consult a licensed qualified health care professional if you experience any adverse reaction to this product. Discontinue use 2 weeks prior to surgery. Do not exceed recommendations for use. use only as directed. Do not use if safety seal is broken or missing. Store in a cool, dry place. KEEP OUT OF REACH OF CHILDREN.

Caffeine

Caffeine is trimethylxanthine stimulant compound that produces effects in the CNS (stimulation/increased focus) and also on the metabolism; there is also evidence that caffeine may inhibit AChE, while increasing noradrenaline and adrenaline levels. Caffeine is both water- and lipid-soluble, and can penetrate the BBB, and readily antagonizes adenosine receptors (especially A₁ and A₂ᴬ). By antagonizing A₁ (which mediates the flow of calcium into the neuron) and A₂ᴬ (which regulate adenylate cyclase activity), caffeine can influence the dopaminergic system and also the sleep/wake cycle. Adenosine binding also appears to suppress tyrosine hydroxylase, which is needed to convert tyrosine into L-Dopa, which is a major step in catecholamine production. Caffeine can elevate energy expenditure (EE) for up to several hours after ingestion (Bukoweicki et al. 1983); studies by Astrup et al. (1990) and Haldi et al. (1941) found that caffeine ingestion can alter EE for up to 24 hours in a dosage-dependent manner. Dulloo et al. (1989) documented increases in thermogenesis after caffeine ingestion, as well as an increase in the thermic effect from food after caffeine ingestion; caffeine has also been shown to increase lipid metabolism and decrease adipocyte number in animal studies.

Multiple studies have confirmed that caffeine does have a lipolytic effect in humans, via measuring plasma free fatty acids and/or glycerol; positive alterations in human studies involving the effects of caffeine on plasma FFA were documented by Daubresse et al. (1973), Arciero et al. (1995), and Ryu et al. (2001). Evidence exists that there are differential effects from caffeine in obese vs. non-obese individuals regarding the ability of the compound to increase thermogenesis, fat oxidation, and lipolysis; Research by Acheson et al. (1980) found that caffeine increases thermogenesis more in nonobese than in obese subjects, and caffeine induced greater increases in lipolysis in nonobese than in obese subjects. Acheson also hypothesized that obese subjects tended to have a lower threshold of tolerance to lipolytic stimulii than nonobese, which may account for the differences encountered between groups. Thong et al. discovered that the increases in plasma FFA and glycerol related to caffeine could be abolished by administration of the β-adrenergic receptor antagonist propranolol; Research by Keijzers et al found that caffeine elevated both epinephrine and plasma FFA in human subjects.

Since the beginning, Applied Nutriceuticals has prided itself with giving our consumers the most cutting-edge and efficacious supplements possible. With this is mind, Applied Nutriceuticals has developed both the Innovation Series and Pure Series, two unique lines of supplements that are not a mere product evolution, but a REVOLUTION in the industry. The Innovation Series utilizes a new and novel approach to delivering our most potent supplements to date, by combining cutting-edge ingredients with unique delivery systems; the Pure Series is comprised of many of the best single-item ingredients on the market, giving customers a great low-cost alternative to other brands- why settle for ordinary when you can have extraordinary? Choose the path not taken, choose the next level, choose the Innovation Series and Pure Series from AN.