The Real Bioinformatics Revolution - Proteins and Nucleic Acids Singing to One Another?

Desk Top Drug Discovery

Letters to the Editor

Technology Watch

Yeasts Targeted for High Ethanol Production

GM Grapevines & Toxic Wines

From the Editors

Science and the Precautionary Principle in UK Government

Everyone
accepts that science and scientific evidence play a major role in deciding
whether the precautionary principle should be invoked and applied. Five years
ago, the UK government seemed to think so too. Its Interdepartmental Liaison
Group on Risk Assessment (ILGRA) produced a report recommending that the
precautionary principle should be invoked “when there is good reason to believe
that harmful effects may occur to human, animal or plant health or to the
environment; and the level of scientific uncertainty about the consequences or
likelihood of the risk is such that the best available scientific advice cannot
assess the risk with sufficient confidence to inform decision-making.”

In
practice, no UK government departments and agencies have made use of the
precautionary principle. And this is particularly the case in dealing with
genetically modified (GM) food and feed, as documented in the report on p. 32,
prepared for the Franco-British Council (FBC) Conference on Risk Management and
Government Policy held in Paris in February 2007 (see opposite).

Our report shows how the regulatory agencies (in UK, Europe and
USA) ignore the precautionary principle, manipulate scientific evidence,
corrupt science and sidestep the law to help promote GM food and feed in the
face of damning evidence piling up.

The abuse of science by the regulatory agencies is particularly
blatant. Scientific evidence is manipulated by a biased and selective review of
the scientific literature and uncritical acceptance of research claiming “no
effect”, including those submitted by the biotech industry that are flawed at
every stage, from experimental design to data collection, analysis, reporting
and interpretation. Science is used not only to exclude counter scientific
findings, but also to exclude key evidence from the real world where GM crops
are grown and farm workers and crop handlers fall ill, and livestock die from
the new GM feed. The result is to prevent
the precautionary principle from being invoked, let alone applied.

Scientists have been drawn into a tightly closed loop of
self-reinforcing “advocacy science” to smooth the passage of GM produce into
the market, without regard for safety, or moral, ethical concerns.

At the FBC conference in Paris, it was eerie to hear David Gee,
Project Manager of the European Environment Agency (EEA) talk about some of the
case histories documented in the excellent EEA Report, Late Lessons
from Early Warnings, which covers fisheries, radiation, benzene,
asbestos, polychlorinated biphenyls (PCBs), halocarbons, diethylstilboestrol
(DES), antibiotics as growth promoters, sulphur dioxide, chemical contamination
in the Great Lakes, tributyltin (TCB) antifoulants, hormones as growth
promoters and BSE. GM food/feed looks so much like a replay of these cases in
the “misplaced science, and the wrong kind of science” dominating
decision-making, with devastating consequences.

ILGRA’s report five years ago also stated
that when the precautionary principle has been invoked, the burden of proof shifts away from the regulator
and it is for the proponents of the activity in question to demonstrate an
acceptable level of safety.

Ministers had accepted the report, and a paper issued
jointly by the Treasury and the Cabinet Office stated clearly that the
government would apply the precautionary principle where there is good reason
to believe that irreversible harm may occur and where it is impossible to
assess the risk with confidence.

Unfortunately, almost as soon as the ink was dry on the
documents that stressed the importance of the precautionary principle, new ones
appeared that did not.

The 2005 Treasury document, Managing risks to the public, appraisal guidance, mentioned
the precautionary principle, but only as an afterthought. The contrast with the
earlier position is so great that Lord Broers, the President of the Royal
Academy of Engineering, asked in the House of Lords why the new document made
no reference to the guidance contained in the ILGRA report and whether the
government planned to strengthen what it says about the precautionary
principle. The answer was no.

In the summer of 2006, the House of Commons Select
Committee on Science and Technology produced a report on the use of scientific
advice, and in the course of this they came out against the precautionary principle. It is not clear why
they object to it, because on the one hand they thought it was so strong that
it would hinder progress, and on the other, they agreed with the government’s
Chief Scientific Adviser that it says nothing more than that one should be
cautious.

In fact, neither criticism is valid. The
precautionary principle is a useful tool in risk management but it does not
make decisions for us. And while there are different formulations, the basic
idea is the same.

What the precautionary principle tells us
is that we don’t have to wait until we are certain about the hazard before we
can take measures to mitigate or avoid it. To act or not depends on the nature
of the hazard and the strength of the evidence that we have in front of us. And
we have to make sure that the science is not abused to exclude key evidence and
to misinform ministers and the public.

At
this point, it is still open to the innovator to supply further evidence, and
if that is sufficient to reassure us, then the restriction could be lifted. The
burden of proof is on the innovator; it is for those who want to change the
decision to supply further evidence.

Opponents of the precautionary principle
often claim that it will bring a halt to progress and innovation. They forget
that while in the criminal courts the burden of proof is on the prosecution,
many defendants are convicted. What is required is not proof in the sense of a
mathematical theorem, but proof “beyond reasonable doubt”. Every year,
thousands of ordinary people serve on juries and are perfectly capable of
understanding what this means and reaching verdicts on the basis of the
evidence presented to them.

ILGRA is the only UK government body that has looked
in detail at the precautionary principle. On the basis of their recommendation,
the government accepted that the principle should be part of risk management.
That was the right decision, and they should stick with it. And they should
start to apply it, too.