Background: Angioimmunoblastic T-cell lymphoma (AITL) is a common type of peripheral T-cell lymphoma. AITL can be missed until lymphadenopathy develops in patients initially presenting with skin lesions, as skin biopsy may lack conclusive findings. The expression of follicular helper T-cell (THF) markers in the skin can be an important diagnostic clue. We present a case of AITL with skin lesions positive for CD10 and dim PD1 T-cells, with the purpose of highlighting the potential for diagnosing cutaneous AITL via skin biopsy.

Discussion:Our case highlights the extranodal presentation of AITL with cutaneous lesions displaying the TFH phenotype. Although AITL and the presence of TFH markers is generally studied via lymph node biopsy, the disease often presents with prominent skin findings that can be diagnosed via biopsy. Further insight into markers specific for cutaneous AITL may lead to advances in diagnostic strategies and clinical outcomes of AITL.

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