The Assessment of Oxidative Stress Intensity in Adolescents with Obesity by the Integral Index

International Journal of Biomedicine. 2018;8(1):37-41.
DOI: 10.21103/Article8(1)_OA5
Originally published March 15, 2018

Abstract:

The aim of this research was to assess lipid peroxidation (LPO) and antioxidative defense (AOD) changes in adolescent boys with obesity using the integral index.Materials and Methods: We examined 19 adolescent boys (mean age of 4.41±0.45 years) with obesity of the first degree (the study group). The control group included 23 healthy boys (mean age of 15.12±0.32 years). The study included the collection of anamnestic data, physical examination, and anthropometric data analysis (body weight (BW), height, waist circumference (WC), hip circumference (HC), and body mass index (BMI)). Laboratory analysis included an assessment of the levels of total cholesterol, triglycerides, HDL, LDL, and blood glucose, as well as the intensity of LPO and AOD in blood plasma and primary and secondary products of LPO. To measure the intensity of OS, the oxidative stress index (OSi) was calculated (the ratio of the LPO-AOD system indicators in the study group to average indicators in the control group).Results: We found a statistically significant increase in BW, BMI, SDS BMI, WC, and HC in the study group compared to the control group. The obese patients had higher values of blood glucose, total cholesterol, triglycerides and LDL compared to the control group. In the study group, we found a significant decrease in the concentration of diene conjugates and an increase in the level of ketodienes and conjugated trienes. The values of α-tocopherol and retinol, and SOD activity were significantly decreased in the study group compared to the control group. There were no statistically significant changes in total antioxidant activity and glutathione status components. According to the data received, the OSi level in the group of obese patients increased approximately 7 times, which confirms the results on the development of antioxidant insufficiency in this pathology.

Zhang Y, Wang S. Differences in development and the prevalence of obesity among children and adolescents in different socioeconomic status districts in Shandong, China. Ann Hum Biol. 2012;39(4):290-6. doi: 10.3109/03014460.2012.690888. PubMed

Kuleshova K, Davydov VV. Some peculiarities in the manifestation of oxidative stress and current status of antioxidant system in adolescents of different age groups with obesity, complicated by insulin resistance and without it. Biomeditsinskaya Khimiya . 2014;60(2):264-274. [Article in Russian].

Kolesnikova LI, Dolgikh VV, Prokhorova ZV, Grebenkina LA, Vlasov BY, Ilyin VP. Peculiarities of the state of the system of lipid peroxidation of antioxidant protection" and exchange of calcium in children of adolescent age in essential arterial hypertension. Journal “Pediatria” named after G.N. Speransky. 2010;83(3):10-14. [Article in Russian].

IMRDC

International Journal of Biomedicine is published four times a year by International Medical Research and Development Corporation

About Us

International Journal of Biomedicine (IJBM) publishes peer-reviewed articles on the topics of basic, applied, and translational research in biology and medicine. Original research studies, reviews, hypotheses, editorial commentary, and special reports spanning the spectrum of human and experimental and tissue research will be considered.