In 1772, she was twenty-eight when she married the slightly older newcomer and possible widower Gerrit Heyer. By 1787, their six children had been christened in Albany.

These Heyers raised their family in the Court Street home where Gerrit lived for many years. However, Jannet Van Slyck Heyer seems to have passed on by 1800, when the first ward census showed no adult women living in the Heyer household that included four now adolescent children. Gerrit Heyer died in 1821.