Translation of the abstract (English)

With a heterogeneous clinical picture it’s typical for the Crohn’s disease (CD) to lead to complications such as fistulae and stenosis which leads to the necessity of a surgical intervention. These operations don’t cure the disease and further operations are quite common. The disease of the CD is very variable and cannot be foreseen in its character and progression. Because of this it would be ...

Translation of the abstract (English)

With a heterogeneous clinical picture it’s typical for the Crohn’s disease (CD) to lead to complications such as fistulae and stenosis which leads to the necessity of a surgical intervention. These operations don’t cure the disease and further operations are quite common. The disease of the CD is very variable and cannot be foreseen in its character and progression. Because of this it would be desirable to rely on certain markers, which are able to identify patients with a high risk for complications and an accelerated progression of disease. Based on this condition it would be possible to tread patients from the first diagnosis onwards with aggressive medicine which prevents the development of fistulae and stenosis. This therapy might lead to some unwanted issues but it also might be able to prevent a patient from a life of suffering of several sever complications.
This work contributes to the development of such markers. Therefore a cohort of 363 patients identified with CD where analyzed about the presents of the anti-glycan-serum antibodies.
The results of this work demonstrate that the recently described anti-glycan-serum antibodies Anti-C and Anti-L in combination with the already described antibodies ACCA, ALCA, AMCA and gASCA are associated with a complicated Crohn’s disease behavior. The antibodies were associated with complications like fistulae and stenosis, an early disease onset, CD dependent surgery and ileum involvement. This was observed for both quantitative (titer) and qualitative (positivity) antibody responses. A strong and independent association could be found for Anti-L with complications and Anti-L and Anti-C with CD related surgery.
So it was shown, that the new anti-glycan serum antibodies Anti-C and Anti-L combined with ACCA, ALCA, AMCA and gASCA are associated with a complicated disease behavior and may be used to divided Patient with Crohn’s disease in homogeneous subgroups of disease behavior. Through adapted therapy the clinical outcome may be improved. Prior to the use of the antibodies in clinical practice prospective long-term studies are necessary.