UB, I had a recto-vag fistula & used suppositories for proctitis, wasn't an issue for me. It's been many years since then, so ask your gi to make sure, or run the question by your pharmacist. Since it's topical & should dissolve I don't see how it could be an issue, but I'm not a dr, just patient.

I saw your post in the UC forum about ports & I responded, although it was a few days later, check it out when you have time. I have horrible veins & the port was wonderful for me.SusieModerator in Chronic Pain & Psoriasis Forums

Foam enemas would go through tract & burn my lady bits...that was 3 years ago. I’m thinking there’s some correlation between suppositories & my butt pressure pain that makes me think of an abscess. My last EUA in June had no drainage but the CRS unroofed a chronic abscess. At the time I was using suppositories & wondered if that was the thick fluid rather than a bacterial pus...

But as you say they should dissolve. IDK. I could use a suppositories but I’m rather afraid.UC/Crohns - tested positive for MAP antibodies & mycobacterium PG- remissionchronic fistulas. Failed setons...it was pure torture. started Stelara May 24, 2017. Remission since! 150mg imuran

UB, when I had my perianal fistula for 3 years, I used to take both pentasa and steroid suppositories for proctitis and they didn't cause any issues. Enemas, on the other hand, were a real pain in the neck and I couldn't retain them and thus had a number of accidents.GERD, perianal fistula, CD, IBS, persistent mouth ulcers & fissures___________________Meds: Remicade, Cortiment, Nexium, bi-weekly B12 inj., vitamin D, calcium & magnesium suppl. Pred 40 mg from Oct. 2010 till Jan. 2012Previous: Mesalamine tablets & supp.Failed:Azathioprine (generic), Methotrexate