Products made from the leaves of green tea are among the most widely consumed natural products worldwide. Claims including cardioprotection, chemoprevention, and weight loss drive green tea beverage and dietary ...

The dried rhizome and root of goldenseal comprise products touted for their antimicrobial properties, gastrointestinal effects, and widely utilized to manage the common cold or other respiratory tract symptoms. Goldenseal ...

Oral cannabis products are widely used for recreational and therapeutic purposes under varying state-specific regulations. Marijuana products often are standardized in relation to psychoactive tetrahydrocannabinol (THC) or non-psychoactive cannabidiol (CBD) ...

Natural Product-Drug Interaction Research

Mission

To create a Center of Excellence that will provide leadership in the study of natural product-drug interactions, with the ultimate goal of developing a definitive approach to determine the clinical relevance of pharmacokinetic interactions between natural products (NPs) and conventional medications.

Objectives

Work collaboratively with NCCIH to identify, prioritize, and source 4-6 NPs as potential precipitants of clinically meaningful interactions with commonly used medications.

Develop a statement of work or administrative supplement for each of the selected NPs to address existing gaps in the scientific literature and provide a definitive assessment about the clinical relevance of any pharmacokinetic interaction.

Develop and maintain a repository and public access portal for the data and resources generated that will lead to improved design of future research.

Establish a set of recommended approaches to address the unique challenges related to the study of NP-drug interactions.

DISCLAIMER

Welcome to the Natural Product-Drug Interaction Research public portal designed to disseminate research findings from the interaction projects available on the publicly accessible database where researchers can access scientific results, raw data, and recommended approaches to optimally assess the clinical significance of pharmacokinetic natural product-drug interactions (PK-NPDIs). This public portal is currently under development.

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