Does anyone know why the parts sometimes turns black when creating e-drawing mark-ups? I always show the part in red, somestimes it will be red in the e-drawing but as soon as I add a mark-up it turns black. Saving out the mark-ups and inserting them in a new e-drawing doesn't help. Once the part it black, it is always black.

It's possible - inverted face normals is fairly common thing that affects imported geometry. One way to eliminate the graphics card / driver as a culprit is to turn on Software OpenGL and try the same file - if the errors go away, then it's definitely graphics card / driver related. If they don't go away, then it could be bad data.

Note that Software OpenGL will slow down your frame rate significantly, so it's not recommended to leave it on.