The story focuses on an elite unit of 5 UBCS members, sent into Raccoon City to try and rescue Dr. Cameron. An Umbrella scientist lost in all the confusion. The UBCS team, consisting of members Rodrigo, Roger, Klaus, Ed and Norman, have a GPS device used to track down Dr. Cameron's last known location, which is near a large food factory.

Upon entering the factory they are attacked by a large creature, a sort of hybrid between a Tyrant and the more evolved forms of Nemesis.