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High-risk patients undergoing terminated lymphadenec- tomy with spot 1 disease do not require adjuvant psychoanalysis to ensure recurrence rates of less than 10 % and an all-embracing survival higher than 80 % <>], in which case decreasing the morbidity associated with undue adjuvant diffusion and chemotherapy. Multiple Targets While single biomarkers are still currently favored about inves- tigat