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Alameddine was born in Amman, Jordan to Lebanese Druze[1] parents (Alameddine himself is an atheist).[2] He grew up in Kuwait and Lebanon, which he left at age 17 to live first in England and then in California. He earned a degree in engineering from the University of California at Los Angeles (UCLA) and a Master of Business in San Francisco.

Alameddine began his career as an engineer, then moved to writing and painting. The author of four novels and a collection of short stories, Alameddine was the recipient of a Guggenheim Fellowship in 2002. He lives in San Francisco and Beirut.