Why is this medication prescribed?Clozapine is used to treat schizophrenia in patients where other medicine has not worked. Clozapine is in a class of medications called antipsychotics. It works by decreasing abnormal excitement in the brain.

How should this medicine be used?Clozapine comes as a tablet to take by mouth. It usually is taken one to three times a day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take clozapine exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

The amount of clozapine you take may need to be adjusted, especially during the first few weeks. You will have weekly blood tests while taking clozapine and for 4 weeks after stopping it. Initially, you will receive only a 1-week supply of this medication at a time.

Continue to take clozapine even if you feel well. Do not stop taking clozapine without talking to your doctor, especially if you have taken large doses for a long time. Your doctor probably will want to decrease your dose gradually. This drug must be taken regularly for a few weeks before its full effect is felt.

Other uses for this medicineThis medication should not be prescribed for other uses; ask your doctor or pharmacist for more information.

What special precautions should I follow?Before taking clozapine,

tell your doctor and pharmacist if you are allergic to clozapine or any other drugs.

in addition to the condition listed in the IMPORTANT WARNING section, tell your doctor if you have or have ever had blood disorders; heart, kidney, or liver disease; depression; epilepsy; problems with your urinary system or prostate; glaucoma; irregular heartbeat; problems with your blood pressure; or blood problems caused by clozapine.

tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking clozapine, call your doctor.

if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking clozapine.

you should know that this drug may make you drowsy.

remember that alcohol can add to the drowsiness caused by this drug.

tell your doctor if you use tobacco products. Cigarette smoking may decrease the effectiveness of this drug.

What should I do if I forget a dose?If you take clozapine several times a day, take the missed dose as soon as you remember it and take any remaining doses for that day at evenly spaced intervals. However, if you remember a missed dose when it is almost time for your next scheduled dose, skip the missed dose.

If you take clozapine once a day at bedtime and do not remember it until the next morning, skip the missed dose. Do not take a double dose to make up for a missed one.

What side effects can this medication cause?Although side effects from clozapine are not common, they can occur. Tell your doctor if any of these symptoms are severe or do not go away:

drowsiness

dry mouth

diarrhea

constipation

restlessness

headache

If you experience any of the following symptoms or those listed in the IMPORTANT WARNINGS section, call your doctor immediately:

tremor

seizures or convulsions

difficulty urinating or loss of bladder control

confusion

eye pain

shakiness

chest pain

severe muscle stiffness

sore throat

unusual bleeding or bruising

upset stomach

vomiting

loss of appetite

yellowness of the skin or eyes

Clozapine can cause high blood sugar (hyperglycemia). If you experience any of the following symptoms, call your doctor immediately:

thirst

dry mouth

tiredness

flushing

dry skin

frequent urination

loss of appetite

trouble breathing

What storage conditions are needed for this medicine?Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.

In case of emergency/overdoseIn case of overdose, call your local poison controlcenter at 1-800-222-1222. If the victim has collapsedor is not breathing, call local emergency services at911.

What other information should I know?Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.