Novi Sad is connected to the region with road and railway routes as well as waterways. It is in the centre of a highway network connecting Northeastern and Eastern Europe to the Middle and Far East, as well as Central and Northern Europe to the ports of the Adriatic Sea.

The city lies on the European Corridor 10 which connects eight countries on its main route from Salzburg to Thessaloniki, and another six countries with its side routes. The European Corridor 7, or the Danube River waterway, connects Western European countries to the Black Sea. Novi Sad is also connected with the Danube – Tisa – Danube canal system, which enables navigation from the Central Europe to the Black Sea. Novi Sad is located on 1,225th kilometre of the Danube flow. The river is wide here and it forms numerous islands, inlets and sandbanks.