so a drug-dispersing suppository can protect against transmission of ...As part of the research Zaveri who earned her doctorate in biomedica...The initial evaluations all were done only in the hand as part of this...Zaveri also studied the release of Tenofovir from the suppositories in... Many people work on drug delivery and use different methods to create...

so a drug-dispersing suppository can protect against transmission of HIV and other sexually transmitted infections during heterosexual intercourse with a partner whose infection status may or may not be known to the woman."

As part of the research, Zaveri, who earned her doctorate in biomedical engineering at the University of Florida, conducted extensive sensory-perception testing to assess acceptability of the suppositories among women. Women participating in the study at the Sensory Evaluation Center in Penn State's Department of Food Science were presented with suppositories -- without the drug -- in a variety of sizes, shapes and textures. They indicated their preferences and rated the suppositories for willingness to try and imagined ease of insertion.

The initial evaluations all were done only in the hand as part of this preclinical development effort. Many factors go into making choices, Zaveri explained, such as vaginal products women may have used previously, as well as their sexual and cultural practices. Understanding women's perception of the suppository and reasons behind their choices is a critical step in the development of the suppository as a vaginal drug-delivery system.

Zaveri also studied the release of Tenofovir from the suppositories in a simulated vaginal environment to ensure that the drug will be released once inserted in the body, even in the presence of semen.

"Many people work on drug delivery and use different methods to create drug-delivery products, but not many focus on the end-user aspect of this," she said. "Obviously, the product can be effective only if it is acceptable to women and they use it. We have gone a step farther with this study to validate the acceptability of our suppositories among women -- and that's critical. We are not just trying to make our product better, we also are trying to understand the reasoning behind the choices women make regarding vaginal drug delivery in general."

(Date:2/24/2015)... Research and Markets ( http://www.researchandmarkets.com/research/sxwl43/global_2d_gesture ... "Global 2D Gesture Recognition Market 2015-2019" report ... forecast the Global 2D Gesture Recognition market to ... period 2014-2019 The increased demand for ... of the major trends in the market. The ...

... interested in natural history but it also challenges those people ... life on Earth. Thats the view of Dr Robert Lambert, ... of Nottingham, who has just returned from the Antarctic in ... Antarctica Tour Operators (IAATO). Dr Lambert, who is a ...

... University of Missouri scientist Ray Semlitsch studies creatures most ... at night and thrive in the shallow, cool, wet ... A collaborative study, with MU graduate student Bill Peterman, ... biomass (total mass of an organism in an area) ...

(Date:3/3/2015)... 3, 2015 Synthetic Biologics, Inc. (NYSE MKT: SYN), a ... a focus on protecting the microbiome, announced today that ... at the 27th Annual ROTH Conference being held on March ... in Dana Point, CA. Mr. ... at 1:00 p.m. (Pacific Time). A live webcast ...

(Date:3/3/2015)... , March 2, 2015 Phillip Sharp, Institute Professor at ... of the Department of Biology and the Koch Institute for Integrative ... at Heritage Day , May 14, at the ... the Othmer Gold Medal since it was first awarded ... "In 1977 Phil Sharp gave the scientific world ...

... Bay, Wis. - Whenever the title executive vice president ... an established part of management. So it is with Judy ... National following a career that she thought was winding ... Green Bay-based provider of global transportation, logistics, and intermodal services, ...

... students are no longer interested in technology careers? , ... Area Technical College has won first place in ... beating four teams from Minnesota, and later advanced to ... third place. , ,The competitions were open to students ...

... a series of articles on raising capital from investors. This installment ... the time when raising equity capital, the offering terms are summarized ... When dealing with angel investors , it is typical ... prospective angel investors will want to negotiate the initial term sheet, ...