MARVEL on RT mutations at position 151

Q151M causes intermediate/high-level resistance to AZT, ddI, d4T and ABC and low-level resistance to TDF, 3TC and FTC. In combination with mutations at the associated positions 62, 75, 77, and 116, Q151M confers high-level resistance to AZT, ddI, d4T and ABC and intermediate-level resistance to TDF, 3TC and FTC.

Q151M causes intermediate/high-level resistance to AZT, ddI, d4T and ABC and low-level resistance to TDF, 3TC and FTC. In combination with mutations at the associated positions 75, 77, and 116, Q151M confers high-level resistance to AZT, ddI, d4T and ABC and intermediate-level resistance to TDF, 3TC and FTC. Q151L is an extremely rare transitional mutation that may precede the emergence of the Q151M.

Mutation

3TC

FTC

ABC

AZT

D4T

DDI

TDF

Q151L

10

10

30

30

30

30

10

Q151M

15

15

60

60

60

60

15

Footnote:Mutation scores on the left are derived from published literature linking mutations and ARVs (the complete details can be found in the HIVdb Release Notes).

Genotype-treatment correlation

Mutation frequency according to subtype and drug-class experience.

The frequency of each mutation at position 151 according to subtype and drug-class experience. Data are shown for the 8 most common subtypes. The number of persons in each subtype/treatment category is shown beneath the subtype. Mutations occurring at a frequency >0.5% are shown. Each mutation is also a hyper-link to a separate web page with information on each isolate, including literature references with PubMed abstracts, the GenBank accession number, and complete sequence and treatment records.

The first row shows the frequency of the mutation in persons who are RTI-naive (indicated in green). The second row shows the frequency of the mutation in persons who have received one or more NRTIs (+/- NNRTIs). The following rows show the frequency of the mutation in persons who have received only a single NRTI. Mutation rates that differ significantly between treated and untreated isolates are indicated in yellow.

Mutation

NRTI

NNRTI

NumSeq

NumMut

% Mutant

p

Q151H

0

0

54727

6

0.00

Q151H

>=1

>=0

25938

6

0.00

0.310

Q151H

AZT

>=0

453

0

Q151H

DDI

>=0

53

0

Q151H

D4T

>=0

55

0

Q151H

ABC

>=0

47

0

Q151H

D4T+3TC

>=0

3499

2

0.00

0.129

Q151H

AZT+3TC

>=0

2667

0

Q151H

D4T+DDI

>=0

462

0

Q151H

AZT+DDI

>=0

581

0

Q151H

ABC+3TC

>=0

326

1

0.30

0.024

Q151H

TDF+3TC

>=0

379

0

Q151H

TDF+FTC

>=0

378

0

Mutation

NRTI

NNRTI

NumSeq

NumMut

% Mutant

p

Q151K

0

0

54727

8

0.00

Q151K

>=1

>=0

25938

3

0.00

0.975

Q151K

AZT

>=0

453

0

Q151K

DDI

>=0

53

0

Q151K

D4T

>=0

55

0

Q151K

ABC

>=0

47

0

Q151K

D4T+3TC

>=0

3499

5

0.10

0.000

Q151K

AZT+3TC

>=0

2667

3

0.10

0.004

Q151K

D4T+DDI

>=0

462

2

0.40

0.000

Q151K

AZT+DDI

>=0

581

0

Q151K

ABC+3TC

>=0

326

0

Q151K

TDF+3TC

>=0

379

0

Q151K

TDF+FTC

>=0

378

0

Mutation

NRTI

NNRTI

NumSeq

NumMut

% Mutant

p

Q151L

0

0

54727

2

0.00

Q151L

>=1

>=0

25938

20

0.00

0.000

Q151L

AZT

>=0

453

0

Q151L

DDI

>=0

53

0

Q151L

D4T

>=0

55

0

Q151L

ABC

>=0

47

0

Q151L

D4T+3TC

>=0

3499

5

0.10

0.000

Q151L

AZT+3TC

>=0

2667

3

0.10

0.000

Q151L

D4T+DDI

>=0

462

3

0.60

0.000

Q151L

AZT+DDI

>=0

581

0

Q151L

ABC+3TC

>=0

326

0

Q151L

TDF+3TC

>=0

379

0

Q151L

TDF+FTC

>=0

378

0

Mutation

NRTI

NNRTI

NumSeq

NumMut

% Mutant

p

Q151M

0

0

54727

0

Q151M

>=1

>=0

25938

707

2.70

0.000

Q151M

AZT

>=0

453

0

Q151M

DDI

>=0

53

0

Q151M

D4T

>=0

55

1

1.80

0.000

Q151M

ABC

>=0

47

1

2.10

0.000

Q151M

D4T+3TC

>=0

3499

117

3.30

0.000

Q151M

AZT+3TC

>=0

2667

11

0.40

0.000

Q151M

D4T+DDI

>=0

462

25

5.40

0.000

Q151M

AZT+DDI

>=0

581

16

2.70

0.000

Q151M

ABC+3TC

>=0

326

3

0.90

0.000

Q151M

TDF+3TC

>=0

379

4

1.00

0.000

Q151M

TDF+FTC

>=0

378

0

Mutation

NRTI

NNRTI

NumSeq

NumMut

% Mutant

p

Q151P

0

0

54727

10

0.00

Q151P

>=1

>=0

25938

4

0.00

1.000

Q151P

AZT

>=0

453

0

Q151P

DDI

>=0

53

0

Q151P

D4T

>=0

55

0

Q151P

ABC

>=0

47

0

Q151P

D4T+3TC

>=0

3499

0

Q151P

AZT+3TC

>=0

2667

1

0.00

1.000

Q151P

D4T+DDI

>=0

462

0

Q151P

AZT+DDI

>=0

581

1

0.10

0.256

Q151P

ABC+3TC

>=0

326

0

Q151P

TDF+3TC

>=0

379

0

Q151P

TDF+FTC

>=0

378

0

Mutation

NRTI

NNRTI

NumSeq

NumMut

% Mutant

p

Q151R

0

0

54727

20

0.00

Q151R

>=1

>=0

25938

11

0.00

0.838

Q151R

AZT

>=0

453

0

Q151R

DDI

>=0

53

0

Q151R

D4T

>=0

55

0

Q151R

ABC

>=0

47

0

Q151R

D4T+3TC

>=0

3499

1

0.00

0.827

Q151R

AZT+3TC

>=0

2667

0

Q151R

D4T+DDI

>=0

462

0

Q151R

AZT+DDI

>=0

581

0

Q151R

ABC+3TC

>=0

326

0

Q151R

TDF+3TC

>=0

379

0

Q151R

TDF+FTC

>=0

378

0

Footnote: About one-half of the untreated isolates belong to non-subtype B isolates; About 20% of the treated isolates belong to non-subtype B isolates; A page containing summaries for all of the mutations at this position can be found here.

Genotype-phenotype correlation

Phenotypes of top 10 common patterns of drug resistance mutations with mutations at position 151.

Mutation patterns are listed in the frequency with which they have been reported in the published literature. The median level of fold resistance (compared with wildtype) for viruses with the mutation pattern in the first column are indicated when available. The subscripts indicate the number of viruses that were phenotyped. The drug susceptibility assay used was the PhenoSense assay (Monogram, South San Francisco). A hyperlink for each individual pattern is provided to access a complete list of mutations and fold resistances for each sequence matching the pattern of mutation.

A complete summary of additional in vitro susceptibility data for viruses with Q151 obtained using other assays including the Antivirogram can be found here. A complete list of all mutation patterns with Q151 (not just the top 10 most frequent patterns) can be found at this page.

Footnote: Mutation patterns were defined by the presence or absence of major NRTI drug resistance mutations ; Sequences containing a mixture at a major drug resistance positions were excluded; For the cutoffs defined by PhenoSense, open the sample report form provided on this page; The full list of all mutation patterns are also available here.

Phenotypic coefficients using machine learning

Least Square Regression (LSR) was used to learn the relative contribution of each mutation to the fold decrease in susceptibility for an ARV. The figure on the left (click to enlarge the figure) shows the regression coefficients (which correlate with the contribution to resistance) for the 23 nonpolymorphic NRTI-resistance mutations shown to contribute decreased susceptibility to at least one NRTI. A complete description of the method that generates this figure can be found at Rhee et al PNAS 2006.