As a visual impaired user, I use a screenreader (Orca), but find both AppImages to be totally inaccessible.

Hello Frans-Willem, I doubt that AppImage changes anything regarding accessibility. How accessible an application is will likely depend on which ingredients the application author has put into the AppImage. After all, an AppImage is just a self-mounting filesystem image that, when executed, mounts itself and executes the payload application.

Are you saying that the same applications, when not run as an AppImage, are more accessible?

As for KeePassXC, it is a Qt application, and the AppImage bundles a private copy of Qt (not the one in the system), which does not use the Qt plugins from the system. Possibly Qt applications need the Qt accessibility plugins to be deployed in order to be accessible? Do you know?

Etcher, on the other hand, is an Electron app. I don’t know whether there is something similar to Qt accessibility plugins for Electron.