The game is set in the same post-apocalyptic future as its predecessor, Metro 2033. In it, mankind is struggling to survive beneath the ruins of post-apocalyptic Moscow, in the tunnels of the Metro, away from the deadly threats outside. People and animals who have been exposed to the poisonous substances filling the skies have become mutants who stalk the catacombs and hunt its inhabitants. The survivors are fighting against each other for the remaining resources instead of standing together to fight these dangerous creatures. They all covet an ultimate weapon; a powerful doomsday device from the military vaults of D6. Civil war among the survivors seems imminent and might lead to the end of humanity.

It is the year 2034. Beneath the ruins of post-apocalyptic Moscow, in the tunnels of the Metro, the remnants of mankind are besieged by deadly threats from outside – and within. Mutants stalk the catacombs beneath the desolate surface, and hunt amidst the poisoned skies above. But rather than stand united, the station-cities of the Metro are locked in a struggle for the ultimate power, a doomsday device from the military vaults of D6. A civil war is stirring that could wipe humanity from the face of the earth forever. As Artyom, burdened by guilt but driven by hope, you hold the key to our survival – the last light in our darkest hour.