Journal of the American College of Cardiology

RISK RECLASSIFICATION WITH ABSENCE OF CORONARY ARTERY CALCIUM AMONG STATIN CANDIDATES ACCORDING TO AMERICAN COLLEGE OF CARDIOLOGY/AMERICAN HEART ASSOCIATION (ACC/AHA) GUIDELINES: SYSTEMATIC REVIEW AND META-ANALYSIS

Author Information

Gowtham Grandhi,

Anshul Saxena,

Tanuja Rajan,

Emir Veledar,

Amit Khera,

Ron Blankstein,

Roger Blumenthal,

Leslee Shaw,

Michael Blaha and

Khurram Nasir

Baptist Health South Florida, Miami, FL, USA

Background

Recent studies have strongly eluded to the importance of absent coronary artery calcium (CAC) in risk reclassification of statin eligible (10-years atherosclerotic cardiovascular disease (ASCVD) risk ≥7.5%) individuals according to the ACC/AHA cholesterol management guidelines. In this systematic review, we aim to summarize the impact of absence of CAC in the reclassification of these individuals to statin non-eligible.

Methods

We included prospective cohort studies with a follow-up of at least 10 years, which have reported data on statin eligibility according to the 2013 AHA/ACC guidelines, with additional data on CAC distribution and ASCVD events.

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RISK RECLASSIFICATION WITH ABSENCE OF CORONARY ARTERY CALCIUM AMONG STATIN CANDIDATES ACCORDING TO AMERICAN COLLEGE OF CARDIOLOGY/AMERICAN HEART ASSOCIATION (ACC/AHA) GUIDELINES: SYSTEMATIC REVIEW AND META-ANALYSIS

RISK RECLASSIFICATION WITH ABSENCE OF CORONARY ARTERY CALCIUM AMONG STATIN CANDIDATES ACCORDING TO AMERICAN COLLEGE OF CARDIOLOGY/AMERICAN HEART ASSOCIATION (ACC/AHA) GUIDELINES: SYSTEMATIC REVIEW AND META-ANALYSIS