Please join us on Thursday, January 17th, for the next presentation in the 2018-19 Regenerative Sciences Seminar Series (RS3). Dr. Ronen Sumagin, PhD, Assistant Professor, in the Department of Pathology, Feinberg School of Medicine, Northwestern University, will present a talk entitled “Neutrophil recruitment patterns and the effector function in inflamed intestinal mucosa”. The seminar will begin at 12:30 in Lecture Hall North, 4th floor of the College of Dentistry, 801 S. Paulina St. A light lunch will be served at 12:15PM.

In the case of bacterial infection and mucosal injury neutrophil transepithelial migration is essential for host defense and tissue homeostasis, however, it may also lead to detrimental inflammation, which is a hallmark of inflammatory disorders of mucosal surfaces, particularly diseases of the gastrointestinal tract, including ulcerative colitis and Cohn’s disease. Our laboratory focuses on interactions of innate immune cells, specifically neutrophils with luminally expressed epithelial adhesive receptors, and the contribution of these interactions to regulation of epithelial barrier and mucosal wound healing, under the conditions of intestinal inflammation. A better understanding of the mechanisms regulating PMN recruitment and retention at the mucosal surfaces, and identification of specific molecules that may link PMN-epithelial cell interactions with epithelial barrier function and wound repair are imperative for the development of new and improved therapeutic approaches aiding in the resolution of mucosal inflammation, and reestablishing epithelial homeostasis.

UIC is a Leader in Regenerative Sciences Research

We are leading investigations into how materials interact with living tissues, and the building of tissue replacements for the growth of cells/tissues to replace lost tissues. The Center for Wound Healing and Tissue Regeneration (CWHTR) is a unique community of scientists and clinicians devoted to the study of injury, wound healing, and regeneration. The Laboratory of Applied Dental Biomaterials and Interfaces is a NIH funded center studying the properties of the tooth in order to develop reparative/regenerative biomaterials to replace lost tooth structure.

Research at the UIC College of Dentistry

Our investigators lead cutting-edge research to discover and translate new knowledge at the boundaries of science, transforming oral health care practice, social systems and related technologies for the benefit of individuals, families and communities.

The University of Illinois at Chicago College of Dentistry is a worldwide leader in oral health education, clinical care and research that is patient-centered and evidence-based, with a foundation in preventive and public health sciences. We are a part of UI Health.