Gregg Gundersen, "LINCing the nucleus to the cytoskeleton in cell polarity, migration and disease"

Dr. Gregg Gundersen is Professor of Pathology and Cell Biology at Columbia University. Research in his laboratory is focused on the fundamental question of how cells generate cellular asymmetry to carry out their specific function. Elements of the cytoskeleton, known as microtubules, have been found to play a central role in this process. The lab works on the role of microtubules in cell polarity and migration and the crosstalk between microtubules and actin filaments, examining how microtubule dynamics are controlled by Rho GTPases. Recent work has been expanded to consider how microtubules regulate focal adhesion dynamics in migrating cells and the role of nuclear positioning in cell polarization and migration.