The duo has signed on to star in National Geographic's upcoming telepic Killing Kennedy, with Lowe set to play the iconic role of President John F. Kennedy and Goodwin joining him as first lady and American royalty Jacqueline Kennedy. Rounding out the cast is Michelle Trachtenberg, in her first Russian-speaking role as Marina Oswald.

"We are thrilled to be working with Rob Lowe, Ginnifer Goodwin and Michelle Trachtenberg, three gifted artists who have responded to this timely, authentic and entertaining material,” said Howard T. Owens, president of the National Geographic Channels, in a statement announcing the news Tuesday. “With Killing Kennedy, timed to coincide with the 50th anniversary of the assassination of JFK, National Geographic Channel continues to bring daring, culturally significant television events to our growing global audience.”

The drama marks the latest adaptation from Bill O'Reilly's collection of best-sellers, and comes three months after Killing Lincoln premiered to 3.4 million viewers. Production will begin in June in Richmond, Va., when Lowe and Goodwin are on hiatus from NBC's Parks and Recreation and ABC's Once Upon a Time, respectively.

Like Killing Lincoln, Kennedy will be produced by Ridley Scott's Scott Free Productions. Nelson McCormick (The Good Wife, Southland) has been tapped to direct, with playwright and screenwriter Kelly Masterson penning the teleplay. The effort, which will tell the provocative story of Kennedy's last days, will run two hours, and is expected to premiere in 171 countries that carry NatGeo.

The move is something of a reunion for Lowe, who narrated NatGeo's April miniseries, The '80s: The Decade That Made Us. The Parks and Rec star has dabbled in other recent telepics, including HBO's Behind the Candelabra and Lifetime's Prosecuting Casey Anthony and Drew Peterson: Untouchable.

Lowe is repped by WME, Brillstein Entertainment Partners and O'Melveny & Myers; Goodwin is with WME, John Carrabino Management and Gendler & Kelly; Trachtenberg (Buffy the Vampire Slayer) is with UTA, Framework Entertainment and Schreck Rose.

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Now, these kids are not destined. In fact, loving each other was a byproduct of their destinies in the sense of their destinies brought them together, but them loving each other actually pushed against their destinies. Their destiny is the mission. Their love distracts from that. The mission wins out. This is their great tragedy. ~ anythingbutgrey, about Cangel