..The absence of exonic mutations in any of the transcripts (FLJ45803, LOC120376, C11orf53 and POU2AF1) mapping to this region makes the association likely to be a consequence of non-coding effects on gene expression...

..We aimed to assess the clinical outcomes of patients who were randomly assigned to EPP or no EPP in the context of trimodal therapy in the Mesothelioma and Radical Surgery (MARS) feasibility study...

..Genome-wide association studies have identified several common genetic variants associated with breast cancer risk. It is likely, however, that a substantial proportion of such loci have not yet been discovered...

..A risk score incorporating a suitably weighted sum of all potentially functional variants in these and a few other candidate genes may provide clinically useful identification of women at high genetic risk...

..Across the four sample sets, the association between rs4939827 and CRC was highly statistically significant (P(trend) = 1.0 x 10(-12))...

Search for low penetrance alleles for colorectal cancer through a scan of 1467 non-synonymous SNPs in 2575 cases and 2707 controls with validation by kin-cohort analysis of 14 704 first-degree relatives

Kate WalkerDepartment of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, and The Academic Department of Biochemistry, The Royal Marsden Hospital, London, UKCancer Res 69:6490-9. 2009

..Most of these hormone-density associations were attenuated with further adjustment for BMI...

Interaction between CHEK2*1100delC and other low-penetrance breast-cancer susceptibility genes: a familial study

..No biallelic mutations were detected among 354 controls. These results confirm that biallelic MYH mutations confer susceptibility to colorectal cancer but are unlikely to account for more than 3% of early-onset colorectal cancer...

Lifetime risks of common cancers among retinoblastoma survivors

Olivia FletcherDepartment of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UKJ Natl Cancer Inst 96:357-63. 2004

..However, their risks for the epithelial cancers that commonly occur after age 50 years are not known...

Low-penetrance susceptibility to breast cancer due to CHEK2(*)1100delC in noncarriers of BRCA1 or BRCA2 mutations

Polymorphisms and circulating levels in the insulin-like growth factor system and risk of breast cancer: a systematic review

Olivia FletcherDepartment of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, United KingdomCancer Epidemiol Biomarkers Prev 14:2-19. 2005

..Further large studies, or combined analysis of data from existing studies, are needed to quantify these effects more precisely...

The insulin-like growth factor system and mammographic features in premenopausal and postmenopausal women

Isabel dos Santos SilvaDepartment of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, United KingdomCancer Epidemiol Biomarkers Prev 15:449-55. 2006

..g. by forcing nearby stem cells to divide before they have repaired their own DNA damage from tobacco smoke). If so, reducing the rate of apoptosis by reducing CHEK2 activity could be protective-although not smoking would be far more so...

..Little is known of the onset of breast cancer in high-risk populations. We investigated the risk of breast cancer in twin sisters and in the contralateral breast taking family history into consideration...

Cancer survival is dependent on season of diagnosis and sunlight exposure

..Currently, there are no comparable estimates of the short-term risk of disease progression in the absence of effective antiretroviral therapy for human immunodeficiency virus (HIV)-infected adults and children...

Cervical cancer and use of hormonal contraceptives: a systematic review

..Human papillomavirus (HPV) is believed to be the most important cause of cervical cancer. Recent studies suggest that long duration use of oral contraceptives increases the risk of cervical cancer in HPV positive women...