CDC - Isocyanates - NIOSH Workplace Safety and Health Topic

Isocyanates are a unit of highly reactive, low molecular exercising weight chemicals. They are wide second hand in the construct of flexible and rigid foams, fibers, coatings so much as paints and varnishes, and elastomers, and are more and more used in the automobile industry, autobody repair, and building insulation materials. Spray-on polymer products containing isocyanates get been formulated for a wide range of retail, commercial, and industrial uses to protect cement, wood, fiberglass, steel and aluminum, including protective coatings for truck beds, trailers, boats, foundations, and decks.

Development of a respiratory sensitization/elicitation protocol of toluene diisocyanate (TDI) in Brown Norway rats to derive an elicitation-based occupational exposure level - ScienceDirect

)-response relation on elicitation-based endpoints. The major goal of scrutiny was to choose the stimulant inhalation threshold dose in sensitized, re-challenged brownish Norway rats, including the related to variables affecting the dosimetry of indrawn TDI-vapor in rats and as to how these differences can be translated to humans. Attempts were made to double at least both traits of human asthma by victimization skin-sensitized rats which were subjected to single or multiple inhalation-escalation questioning exposures. Two types of dose-escalation protocols were used to find the elicitation-threshold was supported an auxiliary pre-studies.