Posts Tagged ‘influenza’

Whether infection with CR59 virus by any of the measures included in our analysis would correlate with protection from subsequent wild-type virus challenge at least in the first few months following vaccination in this population was not determined in this study. However, stimulation of mucosal immunity with CR viruses has in other studies and populations […]

The patient population which received CR59 virus in the current study had more severe obstruction to airflow than that which received the CR37 virus (no history of clinical COPD) and the CR48 virus (mean FEVi/FVC, 61.6 percent). The MRC study used CR48 virus, did not measure serum ELISA antibody or nasal wash antibody responses to […]

The rates of seroresponse to inactivated virus vaccine in our study are similar to those reported in other studies of older adults.*** Our results suggest that administration of CR virus at least six months prior to parenteral inactivated virus vaccine did not enhance the seroresponse rate to the H3 HA component of the inactivated virus […]

The CR59 virus recipients tolerated intranasal live virus infection without significant change in obstruction to airflow measured by spirometry. Previous literature suggests that significant changes in pulmonary function following wild-type influenza A virus acute infection can be detectable for up to three months in patients with COPD. The high percentage of volunteers manifesting infection with […]

The rates in fourfold changes in nasal wash IgA antibody titer to H3 HA were higher in the CR59 virus vaccinees younger than age 65 years compared with the trivalent inactivated virus vaccinees younger than age 65 years to H3 HA (20 [63 percent] vs three te percent], p<0.05) and to HI HA (20 [63 […]

Comparison of Antibody Responses to the Live Attenuated (CR59) and Inactivated Influenza A Virus Vaccines The proportions of volunteers who developed fourfold nasal wash antibody titer rises to H3 HA after CR59 virus vaccination were higher than those following inactivated virus vaccine to either HI or H3 HA. These differences achieved statistical significance when the […]