Current guidelines from the American Heart Association (AHA) and other groups for adults recommend a minimum of at least 150 minutes of moderate-intensity aerobic physical activity (PA) per week. Despite this recommendation, some studies have suggested that even more PA can better protect patients from adverse cardiac events. Prior studies have shown that there appears to be an inverse association between PA and risk of heart failure (HF). “The role of PA in coronary heart disease has been studied comprehensively, but few analyses have focused exclusively on the quantitative relationship between the amount—or specific dose—of regular PA and the risk of HF,” says Ambarish Pandey, MD. In a study published in Circulation, Dr. Pandey and colleagues pooled data from 12 studies from United States and Europe. The analysis collectively included 370,460 patients with varying levels of PA at baseline and 20,203 HF events over an average of follow-up about of 15 years. PA was measured by self-reported levels of activity using standard questionnaires. According to the research team, this approach provided an opportunity to assess the dose-response relationship between PA and HF risk in the general population. More Is Better “Our findings suggest a dose-dependent inverse association between PA levels and risk for HF such that patients who had the highest levels of PA had a significantly lower risk of developing HF than those with the lowest levels of PA,” says Dr. Pandey. This relationship was consistent across all age, sex, race, and geographic location based subgroups studied. Participants who engaged in guideline recommended minimum levels of PA—150 minutes of moderate intensity PA per week—had modest reductions in...