Justification:Mammillaria albiflora is listed as Critically Endangered due to its very restricted range (extent of occurrence and area of occupancy less than 5 km²), its occurrence in a single location, and a continuing population decline as a result of illegal collecting that is also reducing its range. Its population has been diminished by an estimated 50% over the past 20 years, and the decline in mature individuals is continuing. Although a portion of the site has recently been enclosed with a chain link fence to protect it, this did not prevent access to the site.

This species is threatened by illegal collecting. The habitat is now well known to both commercial and amateur collectors. A residential development is in progress in the area which represents a potential threat. However, the developers are interested in the idea of establishing a protected area.

The species is listed on CITES Appendix II, but there is a need to enforce the laws in the countries of destination for international trade. Recently a portion of the site has been enclosed with a chain link fence by El Charco del Ingenio of San Miguel de Allende with the support of the British Cactus and Succulent Society. However, this fence was quickly broken through and does not prevent access to the site. The species has long been propagated around the world.