..The work emphasizes that psychometric measurement continues to develop and reminds us that optimal care of children with atopic dermatitis requires considering its multidimensional effects on both the children and their families...

Association of pediatric psoriasis severity with excess and central adiposity: an international cross-sectional study

..Rarely, an individual shows skin lesions that follow the pattern of type 1 mosaicism, but the rest of the skin shows a milder form of the disorder (type 2 mosaicism). A new study provides the molecular basis for type 2 mosaicism...

..In this article we review recent studies in which differences between the skin properties of infants and young children and those of adults were compared, and we discuss the implications of these differences for sun-protection practices...

..These findings validate pathogenesis-based therapy that provides the deficient end product and prevents accumulation of toxic metabolites, an approach of potential utility for other syndromic lipid metabolic disorders...

..This article provides an overview of the gene, transcripts, and protein structures of laminin alpha3. Also discussed are the proposed functions for the alpha3 subunit-containing laminins...

The epidemiology of molluscum contagiosum in children

Magdalene A DohilDivision of Pediatric and Adolescent Dermatology, Children s Hospital, Department of Pediatrics, University of California, San Diego School of Medicine, San Diego, California, USAJ Am Acad Dermatol 54:47-54. 2006

..Limitations include that this was a retrospective study with a population limited to tertiary pediatric dermatology referral centers...

..The only adverse event reported in 6 months of observation was significant pruritus in one patient. We therefore conclude that tacrolimus ointment is an effective treatment for psoriasis on the face or intertriginous areas in children...

MAS063DP is effective monotherapy for mild to moderate atopic dermatitis in infants and children: a multicenter, randomized, vehicle-controlled study

Mark BoguniewiczDivision of Pediatric Allergy Immunology, Department of Pediatrics, National Jewish Medical and Research Center and University of Colorado School of Medicine, Denver, CO 80206, USAJ Pediatr 152:854-9. 2008

..To examine the efficacy and safety of MAS063DP (Atopiclair) cream in the management of mild to moderate atopic dermatitis in infants and children...

..These studies suggest that GM3 modulates the caveolin-1/EGFR association and is critical for the EGF-induced tyrosine phosphorylation of caveolin-1 that is associated with its inhibition of EGFR activation...

..Given the role of these membrane molecules in suppressing EGFR signaling, up-regulation of GM3, caveolin-1, and CD82 function may be an effective adjunctive therapy for treating epithelial cell malignancies...

..9% in the vehicle group. Imiquimod was well tolerated and appears to be a promising therapeutic option in the treatment of MC in children. Larger studies are needed to confirm the results of this small pilot study...

..To determine the association of changes on nailfold capillaroscopy with clinical findings and genotype in children with juvenile dermatomyositis (DM), in order to identify potential differences in disease course over 36 months...

Pityriasis lichenoides in childhood: a retrospective review of 124 patients

..Pustular psoriasis presenting in the intertriginous areas, and particularly the neck, seems specific to infants and may portend progressive extension to widespread involvement. A limitation is that this was a retrospective case series...

Phenotype of atopic dermatitis subjects with a history of eczema herpeticum

..Clinically, it appears that mutations outside exon 7 are usually associated with a slightly more severe mucocutaneous lipoid proteinosis phenotype, but neurological features do not show any specific genotype-phenotype correlation...

..Atopic dermatitis (AD) is increasingly common, with a point prevalence of more than 30% in some countries, and is characterized by visible skin lesions and intense itching...

In this issue: genotype-phenotype correlations: lessons learned from 'milder' genodermatoses

Amy S PallerJ Invest Dermatol 120:vi-vii. 2003

The economics of topical immunomodulators for the treatment of atopic dermatitis

William AbramovitsBaylor University Medical Center and University of Texas Southwestern School of Medicine, Dallas, Texas, USAPharmacoeconomics 23:543-66. 2005

..TIMs represent an exciting advance in the treatment of atopic dermatitis. Additional research will help determine the proper place of TIMs among the current array of therapeutic options for atopic dermatitis...

Compound heterozygous mutations in the hairless gene in atrichia with papular lesions

Jonathan M SpergelDivision of Allergy and Immunology, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA, USAJ Allergy Clin Immunol 112:S118-27. 2003