This trial is active, not recruiting.

Summary

This research study is looking at a small device that measures white blood cell (WBC) counts
by being placed against the finger nail for participants who are undergoing stem cell
transplantation at Massachusetts General Hospital or have a hematologic malignancy and are
being seen as an outpatient.

Study Design

Commercial portable optical microscope (AM4113-N5UT Dino-Lite ) which will be employed during the study for a pre determined time of non-invasive imaging of the nailfold capillaries in ASCT patients.
For Autologous Stem Cell Transplant (ASCT) participants, the imaging will be performed once prior to ASCT upon admission to the hospital, and then daily after ASCT (starting on day +7) until count recovery

am4113-n5ut dino-lite

Primary Outcomes

Measure

Video of nail-fold imaging captured by capillaroscope

time frame:
4 weeks

Eligibility Criteria

Male or female participants at least 18 years old.

Inclusion Criteria:
- Patients with lymphoid malignancies or plasma cell dyscrasias who are admitted to the
Massachusetts General Hospital to undergo autologous stem cell transplantation or are
seen in the outpatient clinic
- Age ≥ 18 years
- Ability to understand and the willingness to sign a written informed consent
document.
- Patients must have WBC ≥ 3000 / µl and ANC ≥ 1500 / µl at admission or their last
clinical visit to be enrolled.
Exclusion Criteria:
- History of allergic reactions attributed to compounds of similar chemical or biologic
composition of baby oil.
- Myelodysplasia
- Skin photoype < 4 in the Fitzpatrick scale.

Additional Information

Official title

Non Invasive Optical Imaging of Capillaries Through the Nailfold for White Blood Cell Enumeration in Patients With Hematologic Malignancies

Principal investigator

Yi-Bin A Chen, MD

Description

The objective of this study is to obtain data that would support the use of a method to
obtain WBC counts from images of small blood vessels called capillaries. These would be
obtained by pressing a small device on the surface of participants' finger nails to look
through the nail. These images will be obtained using a portable microscope called the
Dino-Lite Digital Microscope.
Having a non-invasive way to quickly measure WBC counts could be useful for a variety of
healthcare applications.

Trial information was received from ClinicalTrials.gov and was last updated in October 2016.

Information provided to ClinicalTrials.gov by Massachusetts General Hospital.