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Several leaders emerged: the princess Anacaona, the chief Hatuey, and the rebel leader Enriquillo. In 1503 a Taino princess named Anacaona reigned in the western region of Hispaniola, where she sought shelter after her husband was kidnapped by Columbus in 1492 and perished en route to Spain. Eager to end Anacaona’s rule, Spanish governor Nicolás de Ovando tricked her into meeting him in September 1503. The princess arranged a banquet to welcome her guests, but Ovando ambushed her unarmed warriors and captured the princess.

In 1479, Columbus married a woman of noble descent with connections to the Portuguese royal court. In 1484, he obtained an audience with King John II, but the king declined to offer Columbus his patronage; he was more interested in reaching India by circumnavigating Africa than in exploring other routes. The royal documents of that period called the sailor by the name Christovao Colom, a Portuguese translation of the Italian original. When Columbus was widowed in 1485, he and his son Diego moved to Spain.

Captured Havana and burned it to the ground. In 1573, Francis Drake (1540–96) raided Panama, and in 1585–86 he looted Santo Domingo. King Philip II of Spain (r. 1556–98) and the colonial governors undertook the task of building fortresses to protect the cities. In 1586, an Italian engineer named Juan Bautista Antonelli (1550–1616), known as the “architect of the King’s defense,” drew up plans for the fortresses El Morro of Havana, El Morro of San Juan, and several other forts and garrisons throughout the Caribbean.