The dosages used in Newton and colleagues' study (1)—160 mg/d of black cohosh root or 200 mg/d of black cohosh and other botanicals—are much lower than those taken by many women. Some commonly used supplements contain 500 mg or more of Cimicifuga racemosa root per capsule, and multiple capsules are taken per day. A daily dose that is 10 times larger than that used in the experiment is not unusual. Assuming that there is a dose dependency to previously demonstrated phytoestrogen properties of black cohosh, it is unfortunate that Newton and colleagues' study only looked at relatively low doses.