Herbert Waldmann and co-workers at Max-Planck-InstitutfurMolekularePhysiologie have reported in ACIE on the target of englerin A. This report is very interesting. When I think of TRPC channels (Transient receptor potential canonical channels), I usually think of our taste buds and how the different electrophiles activate different tastes (bitterness, etc). I guess this calcium influx kills the cancer cells according to the authors. And some how this is all happening selectively for renal cancer cells and not the other kind of cancer cells.