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Unformatted text preview: current as of February 12, 2010. Online article and related content http://jama.ama-assn.org/cgi/content/full/289/23/3106 . 2003;289(23):3106-3116 (doi:10.1001/jama.289.23.3106) JAMA Writing Committee for the ENRICHD Investigators Disease Patients (ENRICHD) Randomized Trial Infarction: The Enhancing Recovery in Coronary Heart Social Support on Clinical Events After Myocardial Effects of Treating Depression and Low Perceived Correction Contact me if this article is corrected. Citations Contact me when this article is cited. This article has been cited 88 times. Topic collections Contact me when new articles are published in these topic areas. Disease/ Myocardial Infarction Psychotherapy; Cardiovascular System; Prognosis/ Outcomes; Cardiovascular Patient-Physician Relationship/ Care; Psychosocial Issues; Psychiatry; Depression; the same issue Related Articles published in . 2003;289(23):3171. JAMA Nancy Frasure-Smith et al. Depression—A Cardiac Risk Factor in Search of a Treatment http://pubs.ama-assn.org/misc/permissions.dtl [email protected] Permissions http://jama.com/subscribe Subscribe [email protected] Reprints/E-prints http://jamaarchives.com/alerts Email Alerts at Princeton University on February 12, 2010 www.jama.com Downloaded from ORIGINAL CONTRIBUTION Effects of Treating Depression and Low Perceived Social Support on Clinical Events After Myocardial Infarction The Enhancing Recovery in Coronary Heart Disease Patients (ENRICHD) Randomized Trial Writing Committee for the ENRICHD Investigators C ARDIOVASCULAR DISEASE IS THE leading cause of death and a major cause of morbidity and disability in the United States, with an estimated 6 million people hav- ing symptomatic coronary heart dis- ease (CHD). 1 Recent studies 2-7 have shown that depression and low per- ceived social support (LPSS) are asso- ciated with increased cardiac morbid- ity and mortality in CHD patients. In patients with CHD, the preva- lence of major depression is nearly 20% and the prevalence of minor depres- sion is approximately 27%. 8-10 After an acute myocardial infarction (MI), de- pression is a risk factor for mortality in- dependent of cardiac disease sever- ity. 4,6 A recent randomized clinical trial found that the antidepressant sertra- line hydrochloride was effective in treat- ing recurrent depression in patients with either an acute MI or an episode of unstable angina. 11 However, no clini- cal trial has examined whether treat- ing depression with counseling or an- tidepressantsafteranacuteMIimproves survival or reduces cardiac risk. The absence of social support is also a risk factor for cardiac morbidity and mortality in patients with CHD. 2,3,5,7 No clinical trial has tested the effects of in- creasing social support on clinical end points following acute MI, although Author Affiliations: The list of Writing Committee members appears at the end of this article....
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