This Program Announcement expires on October 5, 2004, unless renewed.
ADVANCEMENT OF BEHAVIORAL THERAPIES FOR ALCOHOLISM TREATMENT
Release Date: October 11, 2001
PA NUMBER: PA-02-012
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
(http://www.niaaa.nih.gov/)
THIS PA USES "MODULAR GRANT" AND "JUST-IN-TIME" CONCEPTS. MODULAR
INSTRUCTIONS MUST BE USED FOR RESEARCH GRANT APPLICATIONS UP TO $250,000 PER
YEAR. MODULAR BUDGET INSTRUCTIONS ARE PROVIDED IN SECTION C OF THE PHS 398
(REVISION 5/2001) AVAILABLE AT
http://grants.nih.gov/grants/funding/phs398/phs398.html.
PURPOSE
The National Institute on Alcohol Abuse and Alcoholism (NIAAA) is seeking
research grant applications on the clinical use of behavioral therapies for
alcoholism treatment. The term “behavioral therapy” is used broadly to
include a range of nonpharmacological therapies including cognitive-behavioral
therapy, motivational enhancement therapy, twelve-step facilitation, marital
and family therapy, community-reinforcement approach, contingency management,
and brief intervention. To further advance the field of behavioral therapies,
several research areas have been identified and include developing new
innovative therapies; creating or refining behavioral techniques for the
engagement, retention, and adherence of patients in treatment; developing
therapies to manage precipitants of relapse; investigating the effectiveness
of behavioral therapies in group settings; and combining and sequencing of
behavioral and pharmacological treatments. It is recommended that the
development and formulation of new therapies or the refinement of existing
therapies be first tested as small-scale pilot studies prior to conducting
clinical efficacy trials. All applications submitted in response to this
program announcement should be conducted in humans.
HEALTHY PEOPLE 2010
The Public Health Service (PHS) is committed to achieving the health promotion
and disease prevention objectives of "Healthy People 2010," a PHS led national
activity for setting priority areas. This Program Announcement (PA) is
related to one or more of the priority areas. Potential applicants may obtain
a copy of "Healthy People 2010" at http://www.health.gov/healthypeople/.
ELIGIBILITY REQUIREMENTS
Applications may be submitted by domestic and foreign, for-profit and non-
profit organizations, public and private, such as universities, colleges,
hospitals, laboratories, units of State and local governments, and eligible
agencies of the Federal government. Faith-based organizations are eligible to
apply for these grants. Racial/ethnic minority individuals, women, and
persons with disabilities are encouraged to apply as principal investigators.
MECHANISM OF SUPPORT
This PA will use the National Institutes of Health (NIH) research project
grant (R01), exploratory/developmental grant (R21), and small grant (R03)award
mechanisms. Responsibility for the planning, direction, and execution of the
proposed project will be solely that of the applicant. The total project
period for an application submitted in response to this PA may not exceed five
(5) years. Facilities and Administrative (F&A) costs will be awarded based on
the negotiated rate at the time of the award. More detailed information on
the R21 mechanism can be found at
http://grants.nih.gov/grants/guide/pa-files/PA-99-131.html.
Applications requesting direct costs of $500,000 or more in any one year must
obtain written agreement from the NIAAA that the application will be accepted
for consideration of award, in accordance with NIH policy, which is available
at http://grants.nih.gov/grants/guide/notice-files/not98-030.html. Currently,
small grants (R03) are limited to 2 years for up to $50,000 per year for
direct costs, and exploratory/developmental grants (R21) are limited to
$100,000 per year for direct costs for up to 3 years.
Exploratory/developmental grants cannot be renewed: however, a no-cost
extension of up to one year may be granted prior to expiration of the project
period. Investigators are encouraged to seek continued support after
completing an exploratory/developmental grant project through a research
project grant (R01).
Specific application instructions have been modified to reflect "MODULAR
GRANT" and "JUST-IN-TIME" streamlining efforts being examined by the NIH.
Complete and detailed instructions and information on Modular Grant
applications can be found at
http://grants.nih.gov/grants/funding/modular/modular.htm.
RESEARCH OBJECTIVES
Background
Most of the treatments available in the U.S. for alcoholism have been
behavioral in nature. A large number of clinical trials conducted over the
past 15 years have demonstrated effectiveness for several types of behavioral
therapies, including cognitive behavioral therapy, motivation enhancement
therapy, marital family therapy, brief interventions, and community-
reinforcement approach (Hester and Miller, 1995; Fuller and Hiller-Sturmhofel,
1999; National Institute on Alcohol Abuse and Alcoholism, 2000).
Cognitive behavioral coping-skills therapy which aims to improve the patient’s
skills for changing their problematic drinking behavior, has been successful
in improving treatment outcome in alcoholic patients (Longabaugh and
Morgenstern, 1999). Nonetheless, it has been suggested that its effectiveness
can be increased by integrating it with components of other treatment
approaches, such as motivational interviewing (Longabaugh and Morgenstern,
1999). This strategy is currently being implemented and tested by COMBINE, an
ongoing 11-site randomized clinical trial, conducted as a cooperative
agreement by NIAAA.
Motivational enhancement therapy was developed in Project MATCH and involves
strategies to motivate patients to stop or reduce their drinking.
Surprisingly, motivational enhancement therapy proved nearly as effective as
the more intensive cognitive behavioral and twelve-step facilitation therapies
in reducing the frequency and amount of drinking in alcohol dependent patients
(Project MATCH Research Group, 1998). Motivational interviewing, a component
of the motivational enhancement therapy, also appears to aid engagement and
retention of patients in treatment (DiClemente et al., 1999; Miller, 1995).
Twelve-step facilitation interventions have been demonstrated to be effective
in promoting abstinence and in increasing patient’s involvement in Alcoholics
Anonymous (AA) programs (Humphreys, 1999). Results from Project MATCH showed
that AA attendance was associated with more favorable treatment outcomes in
all three therapies (Project MATCH Research Group, 1998).
Brief interventions have been successful in reducing drinking levels in
patients at risk for or experiencing alcohol-related problems (Fleming and
Manwell, 1999; Wilk et al., 1997; Bien et al., 1993). The therapy consists of
providing brief counseling to patients by a physician or nursing staff in five
or less office visits.
Marital family therapy appears helpful in enhancing treatment retention and
improving drinking outcome. For example, behavioral couple therapy which
employs a “sobriety contract” with the spouse, teaches marital communication,
and emphasizes shared activities and positive feelings, increased abstinence
and reduced couple separations and domestic violence (O’Farrell and Fals-
Stewart, 2000).
The community reinforcement approach provides positive reinforcement for
sobriety, eliminates reinforcers for drinking, and teaches new coping
behavior. Studies have demonstrated that the community reinforcement approach
is more successful in reducing drinking than traditional outpatient treatments
(Miller et al., 1999). Integrating the community reinforcement approach with
family therapy also appears promising (Smith et al., 2001).
Contingency management encourages behavioral change in drinking by either
presenting patients with positive reinforcements (e.g., money, vouchers, and
prizes) for meeting treatment goals or employing adverse consequences when
patients relapse to drinking (e.g., withholding of vouchers and writing an
unfavorable report to a parole officer). Although contingency management has
been successfully used to reduce illicit drug use, researchers have only
recently applied this technique to alcoholism. So far, results have been
positive in retaining alcohol dependent patients in treatment and in reducing
their drinking behavior (Higgins and Petry, 1999).
Finally, cue-exposure therapy involves exposing a patient to alcohol-related
cues during therapy. Although few studies have investigated its effectiveness
for alcoholism treatment, the results, so far, have been promising (Monti and
Rohsenow, 1999).
Thus, progress has been made in a broad range of behavioral interventions to
treat alcohol abuse and dependence. Still, many alcoholics do not respond
adequately to currently available behavioral therapies. The purpose of this
program announcement is to improve the overall effectiveness of behavioral
interventions in the engagement, retention, adherence, and outcome of
alcoholism treatment across various populations of alcohol dependent and abuse
subjects.
Specific Areas of Interest
Examples of research opportunities exist in the following areas:
- New and innovative therapies. Since current alcoholism treatments have
modest effects, new therapies and enhancement of existing therapies are
needed. New therapies can be based on promising findings from basic
behavioral and cognitive research, interventions found effective in changing
other problematic behaviors, and theory-driven models of behavioral sciences.
- Engagement and retention of patients in treatment. Treatment providers
consistently state that, from their perspective, research improving retention
should be the number one priority. A beginning has been made to develop
promising behavioral techniques to engage reluctant/ambivalent patients in
treatment using a motivational interviewing model. A behavioral technique that
has shown promise in improving retention is contingency management. But
further research is needed in this important area.
- Patient compliance. Compliance has been shown to be a key determinant of
outcome with medications, with relapse rates lower in those who comply with
the prescribed regimen. At the same time, medical studies often report
noncompliance to medication as a major problem, with as many as 50% of
patients failing to take the medication as prescribed within the first few
weeks of treatment. There is a critical need to develop practical, effective
means to improve patient compliance.
- Precipitants of relapse. Relapse to drinking is common after treatment.
Patients have identified multiple precipitants of relapse including stress,
social pressure, insomnia, anger, depression, anxiety, and environmental cues
associated with prior drinking experiences. Better behavioral techniques to
enable patients to manage these precipitants without resorting to drinking are
needed to improve the long-term treatment of alcoholism.
- Behavioral therapies in group settings. Group therapies are the most
commonly used approach in the treatment of alcoholism. Little research,
however, exists in this area, particularly on how group therapy compares with
individual counseling. Behavioral dynamics and modeling of group sessions and
evaluation of its effectiveness with subtypes of alcoholics in diverse
treatment settings need to be investigated. Research from social psychology
would be informative for studying group therapy.
- Combinations and sequences of treatment. Current alcoholism treatments
yield modest effects. By combining or sequencing treatments, it may be
possible to enhance outcomes, particularly for nonresponders. Combined
interventions can include behavioral therapies as broadly defined in this
program announcement and pharmacotherapies. They might also be focused as
tailored interventions for special populations (see below).
- Natural resolution of alcohol problems. Many problem drinkers,
particularly, those with mild to moderate severity, recover outside of the
formal alcohol treatment system. Identifying the factors involved in natural
resolutions might provide insight into structuring new effective behavioral
interventions.
- Special populations. In this program announcement, special populations
refer to important, often understudied populations with special treatment
needs, such as minorities, the elderly, and women, especially those who are
pregnant. The following are examples of research topics relevant to four
additional special populations:
-- Alcohol abusing and dependent patients with co-occurring psychiatric
disorders. Individuals with alcohol use disorders have high rates of co-
occurring psychiatric comorbidity. Interestingly, this population is more
likely to seek alcoholism treatment than noncomorbid alcoholics are but also
more likely to drop out of treatment. In addition, the prognosis is generally
poorer. Limited research has been conducted in the treatment of this
population. In particular, research is needed to develop specialized
behavioral therapies for comorbid patients. The effects of treating the
concurrent disorders on alcoholism treatment outcomes also needs to be
determined. The intervention strategy to address both the alcoholism and the
psychiatric condition might depend on the kind of comorbidity and perhaps, the
subtype of comorbid alcoholic patient.
-- Develop effective interventions for adolescents with alcohol problems.
Drinking as well as adverse alcohol-related consequences increase year by year
as adolescents approach adulthood. Critical consequences of adolescent
alcohol abuse include impaired social and academic functioning, psychiatric
problems, and high-risk problem behaviors that include polydrug use and
smoking. There is a clear need for behavioral interventions that specifically
focus on the issues and problems of adolescence. Examples of behavioral
therapies that may hold promise but require further research include cognitive
behavioral therapy, motivation enhancement therapy, and family therapy.
Optimal combinations and sequencing of behavioral and pharmacological
interventions need to be investigated for the treatment of the more severely
affected adolescents.
-- Individuals with alcohol use disorders in the criminal justice system.
Approximately 80 percent of the prison and jail inmates are involved in
alcohol and drug use. Limited research, however, exists on understanding
their behavioral complexities and appropriate treatment.
-- Professional health care personnel suffering from alcohol use disorder.
Little research currently exists on treating physicians, nurses, and other
professional health care personnel who have a problem with alcohol.
INCLUSION OF WOMEN AND MINORITIES IN RESEARCH INVOLVING HUMAN SUBJECTS
It is the policy of the NIH that women and members of minority groups and
their sub-populations must be included in all NIH-supported biomedical and
behavioral research projects involving human subjects, unless a clear and
compelling rationale and justification are provided indicating that inclusion
is inappropriate with respect to the health of the subjects or the purpose of
the research. This policy results from the NIH Revitalization Act of 1993
(Section 492B of Public Law 103-43).
All investigators proposing research involving human subjects should read the
UPDATED "NIH Guidelines for Inclusion of Women and Minorities as Subjects in
Clinical Research," published in the NIH Guide for Grants and Contracts on
August 2, 2000
(http://grants.nih.gov/grants/guide/notice-files/NOT-OD-00-048.html);
a complete copy of the updated Guidelines are available at
http://grants.nih.gov/grants/funding/women_min/guidelines_update.htm: The
revisions relate to NIH defined Phase III clinical trials and require: a) all
applications or proposals and/or protocols to provide a description of plans
to conduct analyses, as appropriate, to address differences by sex/gender
and/or racial/ethnic groups, including subgroups if applicable; and b) all
investigators to report accrual, and to conduct and report analyses, as
appropriate, by sex/gender and/or racial/ethnic group differences.
INCLUSION OF CHILDREN AS PARTICIPANTS IN RESEARCH INVOLVING HUMAN SUBJECTS
It is the policy of NIH that children (i.e., individuals under the age of 21)
must be included in all human subjects research, conducted or supported by the
NIH, unless there are scientific and ethical reasons not to include them.
This policy applies to all initial (Type 1) applications submitted for receipt
dates after October 1, 1998.
All investigators proposing research involving human subjects should read the
"NIH Policy and Guidelines on the Inclusion of Children as Participants in
Research Involving Human Subjects" that was published in the NIH Guide for
Grants and Contracts, March 6, 1998, and is available at the following URL
address: http://grants.nih.gov/grants/guide/notice-files/not98-024.html.
Investigators also may obtain copies of these policies from the program staff
listed under INQUIRIES. Program staff may also provide additional relevant
information concerning the policy.
REQUIRED EDUCATION ON THE PROTECTION OF HUMAN SUBJECT PARTICIPANTS
NIH policy requires education on the protection of human subject participants
for all investigators submitting NIH proposals for research involving human
subjects. This policy announcement is found in the NIH Guide for Grants and
Contracts Announcement dated June 5, 2000, at the following website:
http://grants.nih.gov/grants/guide/notice-files/NOT-OD-00-039.html.
DATA AND SAFETY MONITORING PLAN
As of the October 2000 receipt date, applicants must supply a general
description of the Data and Safety Monitoring Plan for ALL clinical trials;
this must be included in the application
(http://grants.nih.gov/grants/guide/notice-files/NOT-OD-00-038.html). The
degree of monitoring should be commensurate with risk. NIH Policy for Data and
Safety Monitoring requires establishment of formal Data and Safety Monitoring
Boards for multi-site clinical trials involving interventions that entail
potential risk to the participants. The absence of this information will
negatively affect your priority score.
URLS IN NIH GRANT APPLICATIONS OR APPENDICES
All applications and proposals for NIH funding must be self-contained within
specified page limitations. Unless otherwise specified in an NIH
solicitation, internet addresses (URLs) should not be used to provide
information necessary to the review because reviewers are under no obligation
to view the Internet sites. Reviewers are cautioned that their anonymity may
be compromised when they directly access an Internet site.
PUBLIC ACCESS TO RESEARCH DATA THROUGH THE FREEDOM OF INFORMATION ACT
The Office of Management and Budget (OMB) Circular A-110 has been revised to
provide public access to research data through the Freedom of Information Act
(FOIA) under some circumstances. Data that are (1) first produced in a
project that is supported in whole or in part with Federal funds and (2) cited
publicly and officially by a Federal agency in support of an action that has
the force and effect of law (i.e., a regulation) may be accessed through FOIA.
It is important for applicants to understand the basic scope of this
amendment. NIH has provided guidance at:
http://grants.nih.gov/grants/policy/a110/a110_guidance_dec1999.htm.
Applicants may wish to place data collected under this PA in a public archive,
which can provide protections for the data and manage the distribution for an
indefinite period of time. If so, the application should include a
description of the archiving plan in the study design and include information
about this in the budget justification section of the application. In
addition, applicants should think about how to structure informed consent
statements and other human subjects procedures given the potential for wider
use of data collected under this award.
APPLICATION PROCEDURES
The PHS 398 research grant application instructions and forms (rev. 5/2001) at
http://grants.nih.gov/grants/funding/phs398/phs398.html must be used in
applying for these grants and will be accepted at the standard application
deadlines (http://grants.nih.gov/grants/dates.htm) as indicated in the
application kit. This version of the PHS 398 is available in an interactive,
searchable format. Although applicants are encouraged to begin using the
5/2001 revision of the PHS 398 as soon as possible, the NIH will continue to
accept applications prepared using the 4/1998 revision until January 9, 2002.
Beginning January 10, 2002, however, the NIH will return applications that are
not submitted on the 5/2001 version. For further assistance contact
GrantsInfo, Telephone 301/435-0714, Email: GrantsInfo@nih.gov.
Applicants planning to submit an investigator-initiated new (type 1),
competing continuation (type 2), competing supplement, or any amended/revised
version of the preceding grant application types requesting $500,000 or more
in direct costs for any year are advised that he or she must contact the
Institute or Center (IC) program staff before submitting the application,
i.e., as plans for the study are being developed. Furthermore, the
application must obtain agreement from the IC staff that the IC will accept
the application for consideration for award. Finally, the applicant must
identify, in a cover letter sent with the application, the staff member and
Institute or Center who agreed to accept assignment of the application.
This policy requires an applicant to obtain agreement for acceptance of the
original application as well as any subsequent revisions. Refer to the NIH
Guide for Grants and Contracts, March 20, 1998 at
http://grants.nih.gov/grants/guide/notice-files/not98-030.html.
SPECIFIC INSTRUCTIONS FOR MODULAR GRANT APPLICATIONS
The modular grant concept establishes specific modules in which direct costs
may be requested as well as a maximum level for requested budgets. Only
limited budgetary information is required under this approach. The
just-in-time concept allows applicants to submit certain information only when
there is a possibility for an award. It is anticipated that these changes will
reduce the administrative burden for the applicants, reviewers and NIH staff.
The research grant application form PHS 398 (rev. 5/2001) at
http://grants.nih.gov/grants/funding/phs398/phs398.html is to be used in
applying for these grants, with modular budget instructions provided in
Section C of the application instructions. Applicants are permitted, however,
to use the 4/1998 revision of the PHS 398 for scheduled application receipt
dates until January 9, 2002. If you are preparing an application using the
4/1998 version, please refer to the step-by-step instructions for Modular
Grants available at http://grants.nih.gov/grants/funding/modular/modular.htm.
Additional information about Modular Grants is also available on this site.
Specific application instructions have been modified to reflect "MODULAR
GRANT" and "JUST-IN-TIME" streamlining efforts that have been adopted by the
NIH. Complete and detailed instructions and information on Modular Grant
applications have been incorporated into the PHS 398 (rev. 5/2001).
Additional information on Modular Grants can be found at
http://grants.nih.gov/grants/funding/modular/modular.htm.
The title and number of the program announcement must be typed on line 2 of
the face page of the application form and the YES box must be marked.
Submit a signed, typewritten original of the application, including the
Checklist, and five signed photocopies in one package to:
CENTER FOR SCIENTIFIC REVIEW
NATIONAL INSTITUTES OF HEALTH
6701 ROCKLEDGE DRIVE, ROOM 1040, MSC 7710
BETHESDA, MD 20892-7710
BETHESDA, MD 20817 (for express/courier service)
REVIEW CONSIDERATIONS
Applications will be assigned on the basis of established PHS referral
guidelines. Applications will be evaluated for scientific and technical merit
by an appropriate scientific review group convened in accordance with the
standard NIH peer review procedures. As part of the initial merit review, all
applications will receive a written critique and undergo a process in which
only those applications deemed to have the highest scientific merit, generally
the top half of applications under review, will be discussed, assigned a
priority score, and receive a second level review by the appropriate national
advisory council or board.
Review Criteria
The goals of NIH-supported research are to advance our understanding of
biological systems, improve the control of disease, and enhance health. In
the written comments reviewers will be asked to discuss the following aspects
of the application in order to judge the likelihood that the proposed research
will have a substantial impact on the pursuit of these goals. Each of these
criteria will be addressed and considered in assigning the overall score,
weighting them as appropriate for each application. Note that the application
does not need to be strong in all categories to be judged likely to have major
scientific impact and thus deserve a high priority score. For example, an
investigator may propose to carry out important work that by its nature is not
innovative but is essential to move a field forward.
(1) Significance: Does this study address an important problem? If the aims
of the application are achieved, how will scientific knowledge be advanced?
What will be the effect of these studies on the concepts or methods that drive
this field?
(2) Approach: Are the conceptual framework, design, methods, and analyses
adequately developed, well-integrated, and appropriate to the aims of the
project? Does the applicant acknowledge potential problem areas and consider
alternative tactics?
(3) Innovation: Does the project employ novel concepts, approaches or method?
Are the aims original and innovative? Does the project challenge existing
paradigms or develop new methodologies or technologies?
(4) Investigator: Is the investigator appropriately trained and well suited
to carry out this work? Is the work proposed appropriate to the experience
level of the principal investigator and other researchers (if any)?
(5) Environment: Does the scientific environment in which the work will be
done contribute to the probability of success? Do the proposed experiments
take advantage of unique features of the scientific environment or employ
useful collaborative arrangements? Is there evidence of institutional
support?
In addition to the above criteria, in accordance with NIH policy, all
applications will also be reviewed with respect to the following:
o The adequacy of plans to include both genders, minorities and their
subgroups, and children as appropriate for the scientific goals of the
research. Plans for the recruitment and retention of subjects will also be
evaluated.
o The reasonableness of the proposed budget and duration in relation to the
proposed research
o The adequacy of the proposed protection for humans, animals or the
environment, to the extent they may be adversely affected by the project
proposed in the application.
o The adequacy of the proposed plan to share data, if appropriate.
AWARD CRITERIA
Award criteria that will be used to make award decisions include:
o scientific merit (as determined by peer review)
o availability of funds
o programmatic priorities.
INQUIRIES
Inquiries are encouraged. The opportunity to clarify any issues or questions
from potential applicants is welcome.
Direct inquiries regarding programmatic issues to:
Cherry Lowman, Ph.D.
Division of Clinical and Prevention Research
National Institute on Alcohol Abuse and Alcoholism
Willco Building, Suite 505
6000 executive Blvd. (MSC-7003)
Bethesda, MD 20892-7003
(For express mail use:
Rockville, MD 20852)
Telephone: (301) 443-0637
FAX: (301)443-8774
Email: clowman@willco.niaaa.nih.gov
Direct inquiries regarding fiscal matters to:
Judy Fox Simons
Grants Management Branch
National Institute on Alcohol Abuse and Alcoholism
Willco Building, Suite 505
6000 executive Blvd. (MSC-7003)
Bethesda, MD 20892-7003
(For express mail use:
Rockville, MD 20852)
Telephone: (301) 443-2434
Email: jsimons@willco.niaaa.nih.gov
AUTHORITY AND REGULATIONS
This program is described in the Catalog of Federal Domestic Assistance No.
93.273. Awards are made under authorization of sections 301 and 405 of the
Public Health Service Act as amended (42 USC 241 and 284) and administered
under NIH grants policies and Federal Regulations 42 CFR 52 and 45 CFR Parts
74 and 92. This program is not subject to the intergovernmental review
requirements of Executive Order 12372 or Health Systems Agency review.
The PHS strongly encourages all grant and contract recipients to provide a
smoke-free workplace and promote the non-use of all tobacco products. In
addition, Public Law 103-227, the Pro-Children Act of 1994, prohibits smoking
in certain facilities (or in some cases, and portion of a facility) in which
regular or routine education, library, day care, health care or early
childhood development services are provided to children. This is consistent
with the PHS mission to protect and advance the physical and mental health of
the American people.
REFERENCES
Bien, T.H., Miller, W.R., & Tonigan, J.S. (1993) Brief interventions for
alcohol problems: A review. Addiction 88:315-336
DiClemente, C.C., Bellino, L.E., & Neavins, T.M. (1999) Motivation for change
and alcoholism treatment. Alcohol Research & Health 23:86-92.
Fleming, M., & Manwell, J.B. (1999) Brief intervention in primary care
settings. Alcohol Research & Health 23:128-137.
Fuller, R.K., & Hiller-Sturmhofel, S. (1999) Alcoholism treatment in the
United States: An overview. Alcohol Research & Health 23:69-77.
Hester, R.K. and Miller, W.R. (1995) Handbook of Alcoholism Treatment
Approaches, Second Edition, Boston: Allyn and Bacon.
Higgins, S.T. and Petry, N.P. (1999) Contingency management: Incentives for
sobriety. Alcohol Research & Health 23:122-127.
Humphreys, K. (1999) Professional interventions that facilitate 12-step self-
help group involvement. Alcohol Research & Health 23:93-98.
Longabaugh, R., & Morgenstern, J. (1999) Current status and future
directions. Alcohol Research & Health 23:79-85.
Miller, W.R. (1995) Increasing motivation for change. In R.K. Hester & W.R.
Miller (editors), Handbook of Alcoholism Treatment Approaches: Effective
Alternatives, 2nd Edition, Needham Hights, Massachusetts: Allyn & Bacon, pp.
89-104.
Miller, W.R., Meyers, R.J., & Hiller-Sturmhofel, S. (1999) The community-
reinforcement approach. Alcohol Research & Health 23:116-127.
Monti, P.M. & Rohsenow, D.J. (1999) Coping-skills training and cue-exposure
therapy in the treatment of alcoholism. Alcohol Research & Health 23: 107-
115.
National Institute on Alcohol Abuse and Alcoholism (2000) New Advances in
Alcoholism Treatment. Alcohol Alert 49:1-4.
O’Farrell, T.J., & Fals-Stewart, W. (2000) Behavioral couples therapy for
alcoholism and drug abuse. Journal of Substance Abuse Treatment 18:51-54.
Project MATCH Research Group (1998) Matching patients with alcohol disorders
to treatments: Clinical implications from Project MATCH. Journal of Mental
Health 7:589-602.
Smith, J.E., Meyers, R.J., & Miller, W.R. (2001) The Community reinforcement
approach to the treatment of substance use disorders. The American Journal on
Addictions 10(Supplement): 51-59.
Wilk, A.I., Jensen, N.M., & Havighurst, T.C. (1997) Meta-analysis of
randomized control trials addressing brief interventions in heavy alcohol
drinkers. Journal of General Internal Medicine 12:274-283.