Strategy Phase III Intergroup Study for Chemotherapy of the Metastatic or Locally Advanced Cancers of the Stomach

Trial Information

Strategy Phase III Intergroup Study for Chemotherapy of the Metastatic or Locally Advanced Cancers of the Stomach

To compare the effectiveness of two different sequences of polychemotherapy among carrying
patients of a adenocarcinoma of the stomach or cardia locally advanced or metastatic.

Inclusion Criteria:

- age = 18 years old

- patients carrying a adenocarcinoma of the stomach or cardia histologically proven

- locally advanced tumour which may not be treated surgically or metastatic tumour

- the patients having a stenosante tumour responsible for a disphagy had to have a
tumoral ablation or a prosthesis or a probe of food,

- measurable lesions according to criteria RECIST (specify measurement by spiral
scanner of largest diameter of with less the one lesion of size higher than 1 cm) or
appraisable but nonmeasurable (lesions < 1 cm, ascite, pleural effusion...)

- general state WHO < 2

- absence of insufficiency cardiac or coronary symptomatic

- absence of previous chemotherapy other that auxiliary stopped since more than 6
months

- filled questionnaires QLQ C30 and STO-22

- PNN = 1500/mm3, haemoglobin ≥ 10g/dl, plates= 100 000/mm3

- creatinin ≤ 110 micromol/l

- bilirubin ≤ 35 micromol/l

Exclusion Criteria:

- disphagy or intestinal obstruction incompatible with a treatment per os or by a probe
of food

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