– New framework simplifies and accelerates access to CRISPR intellectual property for research

Merck , a leading science and technology company, and the Broad Institute of MIT and Harvard (Boston, Massachusetts) today announced an agreement to offer non-exclusive licenses to CRISPR intellectual property (IP) under their respective control for use in commercial research and product development.

“Together with the Broad Institute, we are simplifying the path to licensing CRISPR technology, which will make it more widely available to the global research and discovery community,” said Udit Batra, member of the Merck Executive Board and CEO, Life Science. “Through this agreement, we will make it easier for our customers to be successful in their research that shortens drug development timelines for previously untreatable diseases.”

Broad Institute and Merck share the goal of enabling all entities to apply the technology with a wider range of CRISPR tools. To streamline access for scientists, Broad Institute will offer licenses to Merck’s and Broad Institute’s CRISPR IP portfolios to potential licensees for internal research use and for commercial research tools and kits. Under the agreement, companies applying CRISPR in their research and development activities can license both sets of IP through Broad Institute. The framework is designed to allow other key patent holders to participate in the future — either through this framework or via a third-party patent pool or collaboration — to further streamline non-exclusive access to key CRISPR technology.

“We believe that key CRISPR patent holders should come together to simplify and open up access, and this agreement is another example of a partnership that helps maximize and streamline access to these important scientific tools,” said Issi Rozen, chief business officer of the Broad Institute. “Broad Institute already licenses CRISPR non-exclusively for all applications, with the exception of human therapeutics. We are actively working to ensure the widest and simplest possible access to key CRISPR intellectual property.”

The institutions worked together to develop a framework that (i) continues to provide non-exclusive access to Broad-controlled IP co-owned with its collaborators (including Harvard University, the Massachusetts Institute of Technology, New York Genome Center, New York University, The Rockefeller University, the University of Iowa Research Foundation, The University of Tokyo, the Whitehead Institute for Biomedical Research and others) and (ii) provides non-exclusive access to IP from Merck, with certain limitations specific to the Merck IP for creation of rodent models.

Features of the licensing framework:

— Merck’s IP for CRISPR technology, offered under the Sigma-Aldrich

portfolio brand, will become available royalty-free to non-profit

academic institutions, non-profit business communities and

governmental agencies for their internal research, consistent with

the Broad Institute’s long-standing practice and requirements.

— Licenses follow Broad Institute’s and Merck’s ethical licensing

considerations, which exclude certain CRISPR technology applications,

such as any for clinical human germline editing.

— Each organization can continue offering licenses independently,

outside of this framework.

— In addition to IP from Broad Institute and Merck, this licensing

framework includes certain Broad IP co-owned with multiple other

institutions: Harvard University, the Massachusetts Institute of

Technology, The Rockefeller University, the University of Iowa

Research Foundation, the University of Tokyo, the Whitehead Institute

for Biomedical Research and others.

Broad Institute and Merck have each developed guidelines that support research with genome editing under careful consideration of ethical and legal standards. The Broad Institute outlines “institutional policies on IP licensing” on its website. Merck has established an independent, external Bioethics Advisory Panel to provide guidance for research in which its businesses are involved, including research on or using genome editing, and has defined a clear operational position taking into account scientific and societal issues to inform promising therapeutic approaches for use in research and applications.

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