The possibility of allergic sensitivity including an anaphylactoid reaction, should be kept in mind.

Infrequently, usually after repeated injection, erythematous, indurated, pruritic plaques have occurred; rarely, these have progressed to scleroderma-like lesions that have persisted for long periods. In other cases, these lesions have resembled erythema perstans.

Hyperbilirubinemia has been observed in the newborn following administration
of phytonadione. This has occurred rarely and primarily with doses above those
recommended. (See PRECAUTIONS, Pediatric Use.)

DRUG INTERACTIONS

Temporary resistance to prothrombin-depressing anticoagulants may result, especially when larger doses of phytonadione are used. If relatively large doses have been employed, it may be necessary when reinstituting anticoagulanttherapy to use somewhat larger doses of the prothrombin- depressing anticoagulant, or to use one which acts on a different principle, such as heparinsodium.