What molecule recognizes pathogen in the lectin complement pw?

While MBL binds mannose, ficolins bind ___________.

Oligosaccharides

What 2 serine proteases are MBL associated w/?What classical pw complement molecules are they similar in function to?

MASP 1 and MASP 2- Similar to C1r and C1s

10

How are MASP 1/2 activated?How does this differ from the classical complement pw?

Activated upon MBL binding to Ag surface- Bind directly to pathogen surface, not to AB

11

Upon initial activation of C1s in the classical complement cascade, what important convertase is first created? (name and function)

C4b2a, a C3-convertase

12

Once C4b2a (C3-convertase) is created in the classical complement pw, what convertase is created next? (name and function)

C4b2a3b, a C5-convertase

13

Upon initial activation of MASP-2 in the lectin complement cascade, what important convertase is first created? (name and function)

C4b2a, a C3-convertase

14

Once C4b2a (C3-convertase) is created in the lectin complement pw, what convertase is created next? (name and function)

C4b2a3b, a C5-convertase

15

What is MAC?Does it mostly kill gram - or + ? (give e.g.)How is it created?

Membrane Attack Complex: creates a pore in a pathogen to lyse it (many viruses)- Gram-negative (Neisseria spp.)- Once a C5-convertase is formed, C5 -> C5b. Then C6, C7, C8, and up to 16 C9's join to form the MAC

16

How does the alternative complement pw get started?

- Hydrolysis of C3 (slowly occurs spontaneously in plasma)

17

How is the C3-convertase formed in the alternative pw? (name it as well)