ENZYME entry: EC 3.4.21.108

Accepted Name

HtrA2 peptidase.

Alternative Name(s)

High temperature requirement protein A2.

HtrA2 protease.

Omi stress-regulated endoprotease.

Serine proteinase OMI.

Reaction catalysed

Cleavage of non-polar aliphatic amino-acids at the P1 position, with a preference for Val, Ile and Met. At the P2 and P3 positions, Arg is selected most strongly with a secondary preference for other hydrophilic residues

Comment(s)

Up-regulated in mammalian cells in response to stress induced by both
heat shock and tunicamycin treatment.

Can induce apoptosis in a caspase-independent manner through its
peptidase activity and in a caspase-dependent manner by disrupting
the interaction between caspase and the inhibitor of apoptosis (IAP).