England and Wales are set to contest a mammoth clash in the leafy London suburb of Twickenham on Saturday in the second round of Six Nations fixtures.

In what is being billed as a vital clash for both sides, England have most aspects in their favour – home advantage, strength in depth and the guidance of arguably the world’s greatest coach in Eddie Jones.

But if there is one thing that has proven near impossible to predict over the years, it is the result of the fixture between these two great rivals.

Wales, buoyed by their success against a Scotland side who enjoyed a good autumn, have named an unchanged starting line-up for the game.

George North replaces centre Owen Watkin on the bench in the only change to the match day 23, due to insurance needed because of a minor strain suffered by Josh Adams, according to Warren Gatland.

The supposed new style adopted by Wales certainly paid dividends against the Scots – critics might say this was more to do with the prevalence of Scarlets in the Welsh ranks than any strategy enacted by the coaching team.

Pursuing the same strategy against England might be a little risky.

With the dominance of the English pack, particularly with regards to the scrum, any handling or breakdown errors are likely to be punished.

The English XV will not experience the same good fortune against the Welsh defence, famously aggressive in its line speed, but Wales will still have to be wary of the Ford-Farrell axis and outstanding individuals such as Anthony Watson.

But this attacking threat isn’t exclusive to England’s lightning backs; forward stars such as relative newcomer Sam Simmonds could pose a danger to the Welsh try line.

Given how potent England were last Sunday, it should come as no surprise to supporters that wholesale changes in the match day 23 have not materialised.