Webcomics pioneer Brad Guigar started posting a daily comic strip on the Web on Feb. 14, 2000 and has been continuously publishing — on the Web and in print — ever since. His first strip, "Greystone Inn," ran six days a week from 2000-2005.

“Evil Inc,” a comic about a company run for supervillains by supervillains, started the week after "Greystone" ended. Reimagined as a graphic novel in 2016, "Evil Inc" updates in two partial-page updates each week at...