Circulating nucleated cell populations found in whole blood, including both white blood cells (leukocytes) and endothelial cells, provide an ideal platform for studies seeking to understand the disease processes for development of drugs and...

Nanomaterials have many intriguing applications in biology and medicine. Unique properties such as enhanced electrical properties, increased chemical reactivity and resistance to degradation, novel optical properties and comparable size to that of...

Wound healing is a highly concerted cellular process that begins with inflammation and proceeds to resolution to revascularize the site of injury. Although inflammation is essential to revascularization during wound healing, it is now recognized...

AMP-activated protein kinase, AMPK, is a conserved serine/threonine kinase with a critical function in the regulation of metabolic pathways in eukaryotic cells. Recently, AMPK has been shown to play an additional role as a regulator of inflammatory...

Age-related alterations in innate immunity are poorly understood. The identification of those mechanisms, which are dysfunctional in old age, will shed light on potential therapeutic strategies for chronic inflammatory diseases prevalent in the...