The protein encoded by SLC7A2 is a cationic amino acid transporter and a member of the APC (amino acid-polyamine-organocation) family of transporters. Additionally we are shipping SLC7A2 Proteins (5) and SLC7A2 Kits (4) and many more products for this protein.

Activation of PKCalpha (show PKCa Antibodies) by phorbol esters or thymeleatoxin causes a transient increase of arginine transport through system y(+), referable to the induction of SLC7A2 mRNAs and to the increased expression of CAT2 transporters.

In the absence of CAT2, Myeloid-derived suppressor cells display diminished capacity for controlling T cell immunity in prostate inflammation and cancer models, where the loss of CAT2 results in enhanced antitumor activity.

demonstration of how most nuclear-retained CTN (show CALCA Antibodies)-RNAs stabilize at the periphery of paraspeckles, how CTN (show CALCA Antibodies)-RNA regulates its protein-coding partner, and how the mCAT2 gene can maintain a stable expression

cationic transporter CAT2 plays an important role in controlling inflammation and IL-17 (show IL17A Antibodies) activation in an injury model of colitis

These results demonstrate that the availability of arginine, mediated by Slc7a2, controls critical aspects of macrophage activation and reveal a factor for susceptibility to Leishmania infection.

SLC7A2 Antigen Profile

Protein Summary

The protein encoded by this gene is a cationic amino acid transporter and a member of the APC (amino acid-polyamine-organocation) family of transporters. The encoded membrane protein is responsible for the cellular uptake of arginine, lysine and ornithine. Three transcript variants encoding different isoforms have been found for this gene.