FBW7 (F-box and WD repeat domain-containing 7) has been characterized as an onco-suppressor protein in human cancers.

Recent studies have also shown that FBW7 exerts its anti-tumor function primarily by promoting the degradation of various oncoproteins, through which FBW7 regulates cellular proliferation, differentiation and causes genetic instability.

Fbw7-knockout mouse models support Fbw7 as a tumor suppressor gene in the development and progression of human malignancies.

FBW7 is also a tumour suppressor, the regulatory network of which is perturbed in many human malignancies.

Numerous cancer-associated mutations in FBW7 and its substrates have been identified, and loss of FBW7 function causes chromosomal instability and tumorigenesis.