Cardiovascular Disease

As the nation’s leading cause of death,
cardiovascular disease is the subject of important research at
UB’s New York State Center of Excellence in Bioinformatics
& Life Sciences (CBLS).

Research related to heart failure and sudden death
is conducted here, as is work focused on a range of leading-edge
therapies and technologies, including:

Cardiovascular tissue engineering

Adult stem cells for tissue engineering

Wound healing

Biomaterials and gene delivery for tissue
regeneration

Gene modified skin for protein delivery

Functional genomics in tissue engineering

Faculty and members of the Division of
Cardiovascular Medicine are actively involved in advanced
investigation funded through National Institutes of Health (NIH),
the U.S. Department of Veterans Affairs (VA), and medical
foundations and industry. They have led major multicenter clinical
trials, as well as single-center patient-oriented
investigation.

Preclinical research areas of focus include:

Investigation in chronic adaptations of the heart to ischemia,
heart failure, angiogenesis and sudden cardiac death using
molecular imaging and high-throughput molecular biology

Development of novel approaches to improved heart function with
the aid of therapeutic interventions, like in vivo gene transfer
and cell based therapy, that can ultimately be used in a clinical
setting

The division’s facilities include
state-of-the-art laboratories for preclinical investigation, and
are located in UB’s Clinical and Translational Research
Center (CTRC), which sits above Kaleida Health’s Gates
Vascular Institute (GVI). This proximity will allow for the
delivery of collaborative clinical care, including patient
evaluation and follow-up for clinical trials, and advanced clinical
cardiovascular imaging.