I have not heard of that particular model and I would be doubtful of its
utility. You must be more precise in your model than asking for global brain
ischemia. For example, if you are studying stroke, then the Pulsinelli model
of 4 vessel occlusion is the best (or at least the most widely used). If on
the other hand you are studying cardiac arrest models, then you must produce a
cardaic arrest. The difference between the two models is what is going on
with the rest of the body. Serum from cardiac arrested rats causes several
toxic effects when administered to a normal rat. There is some type of
synergism between different areas of the body during ischemia so that the two
models produce different results. Good luck
Gary
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Gary Krause (gkrause at cms.cc.wayne.edu)
Department of Emergency Medicine
Wayne State University, Detroit, MI USA