Abstract: DC-SIGN (dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin) belongs to the major members of C-type lectin family， which is a PRR (pattern recognition receptor) and can mediate cell adhesion. DC-SIGN can specifically recognize glycoconjugates containing mannose or fucose in various exogenous antigen of pathogens， endogenous self-antigen and intercellular adhesion molecule 2，3 (ICAM-2， 3) by its lectin carbohydrate recognition domain. Moreover， it is also involved in immune escape of tumor cell or pathogens mediated by dendritic cells (DCs) through cross-talking with Toll like receptors. In the initial response of inflammation， DC-SIGN modulates the adhesion and migration of DCs to activate naive T-cell. Therefore， as an innate immune molecule， DC-SIGN plays an crucial role in infectious and inflammatory diseases through its positive and negative immunoregulatory effects on DCs. However， the immunoregulation mechanisms of DC-SIGN including signal transduction and expression regulation have not been fully elucidated. We have reviewed some progress in this field here.