RoLi Lab: Microscope Design and Optogenetics

RoLi Lab: Systems and Behavioral Neuroscience

RJF Jennifer Li

Dr. Edwin Land founded the Rowland Institute to foster high-risk creative research. The Rowland Junior Fellowship Program was established to fund young scholars with the potential to establish a ground-breaking research program in their chosen field. Rowland Junior Fellows are selected to perform independent experimental research for five years, with full institutional support and access to the Institute's outstanding technical and scientific resources. We appoint on average two new Rowland Junior Fellows per year. We seek the best young experimentalists in all areas of science and engineering. This year research projects in energy science and neuroscience, broadly defined, are of particular interest. To learn more about applying see: Rowland Junior Fellowship Program

Spotlight on RJF SJ Claire Hur

Combination therapy has become one of the leading approaches for treating complex diseases because it coadministers clinically proven drugs to concurrently target multiple signaling pathways of diseased cells. Identification of synergic drug combinations at their respective effective doses without unwanted accumulative side effects is the key to success for such therapy. In this work, we demonstrate the feasibility of the vortex-assisted microfluidic electroporation system for direct drug cocktail analyses where drug substances were individually delivered into cytosols in a sequential and dosage-controlled manner. Through quantitative analyses, the synergic combinational dosage ratios of the chemotherapeutic drug and the anticancer flavonoid were identified. When integrated with high-throughput label-free rare cell purification techniques, the presented system has the potential for development of personalized medicines as the system would be capable of comprehensively assessing drug combinations directly on patients’ cellular samples.