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Concerns about the vitality of faculty careers at U.S. medical schools have been well documented, as medical school leaders and researchers have raised awareness about overall career satisfaction, faculty stress and burnout, and struggles with recruitment and retention. Previous research has demonstrated an empirical link between job satisfaction and retention as well as job dissatisfaction and intent to leave an organization. This Analysis in Brief examines key areas of medical faculty job satisfaction and dissatisfaction and the disconnect for some faculty members between what they value in the workplace and actual workplace opportunities.