During the first part of the sixth season of Beverly Hills, 90210, Kamel appeared on several episodes as Anthony Marchette, an organized crime figure who ordered the car bombing of Jack McKay, father of Dylan McKay (Luke Perry). In Kamel's final appearance in the series, one of his hit men mistakenly killed Anthony's daughter, Antonia (Rebecca Gayheart), who had married Dylan earlier in the episode against her father's wishes. Anthony and Dylan had a final showdown at Toni's gravesite following her burial, but Dylan walked away, denying Anthony's wish that he be shot to death.

Kamel was most recently known for his role as 'Dr. Charles Kroger' in the USA Network television series Monk, playing the infinitely patient and ever supportive psychiatrist to the main character, Adrian Monk (Tony Shalhoub). Though his last appearance was in the sixth season of Monk, clips of his character were seen later in the series finale.

On April 8, 2008, Kamel was found dead in his Hollywood Hills home. Police investigators ruled that the cause of death was a heart attack. He was 65.[4][5] The Monk episode "Mr. Monk Buys a House" was dedicated to his memory. Kamel never married and did not have any children of his own. He was survived by two brothers, Dr. Stephen Kamel (a dentist) and Robert Kamel, five nieces and nephews, and six grandnieces and grandnephews. [6]

^Beale, Lewis. "BIG BOUNCE FROM 'MURDER' SHRINK ROLE", Daily News (New York), January 22, 1996. Accessed March 20, 2011. "Kamel is one of those looks-familiar-but-what's-his-name actors who work all the time but seem to miss stardom. The South River, N.J., native has had recurring roles in many TV series, but his best work has been in Hill Street Blues,L.A. Law and Murder One, all created by Stephen Bochco."