The P2X7 receptor is an ATP-gated ion channel primarily expressed on cells of the immune system and is thought to play an important role in inflammatory processes through the regulation of a number of proinflammatory cytokines. P2X7 receptor antagonism may provide a novel approach to the treatment of rheumatoid arthritis and other inflammatory conditions, which affect millions of individuals.

The first Phase I study is a double-blind and placebo-controlled single ascending dose study in healthy male volunteers to evaluate the compound’s safety, tolerability, pharmacokinetic profile and pharmacodynamic effects after oral administration.

Michael G Kelly, Ph.D., President, Renovis, Inc., Evotec’s US subsidiary, commented: “We are extremely pleased to announce today the achievement of this second important clinical milestone at our US site following its integration into Evotec earlier this year. The initiation of Phase I studies with our P2X7 receptor antagonist is the culmination of the efforts of many of our dedicated R&D staff over the past few years and we have high expectations as we progress further into development.”

Forward-Looking Statements
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