If a game has no multi-player modes, does this ever turn you away from purchasing specific games?

I Know for me, if there is no multi-player modes available, after I finish the game I'll most likely never play it again. So I tend to hesitate when contemplating on purchasing a game with no multi-player options.

Game like Prototype, was a fun game (for a while), but no multi-player modes. As soon as I got to the point where my character was pretty much upgraded to where almost nothing hurt him, I got bored.

Hmmm good question, I used to hate games with multiplayer, I always liked to play by myself (i.e. RPGs). However, now that I have experienced next gen gaming, multiplayer is almost a must have. I will buy single player games if they are awesome (i.e. Valkyria Chronicles, Fallout 3, etc.) But nowadays, I find myself searching for multiplayer games first, then single player second.