Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Target Data

Function

Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis. Moreover, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC); as well as in the fragmentation of the Golgi apparatus during mitosis. The substrates include transcription factors (such as ATF2, BCL6, ELK1, ERF, FOS, HSF4 or SPZ1), cytoskeletal elements (such as CANX, CTTN, GJA1, MAP2, MAPT, PXN, SORBS3 or STMN1), regulators of apoptosis (such as BAD, BTG2, CASP9, DAPK1, IER3, MCL1 or PPARG), regulators of translation (such as EIF4EBP1) and a variety of other signaling-related molecules (like ARHGEF2, FRS2 or GRB10). Protein kinases (such as RAF1, RPS6KA1/RSK1, RPS6KA3/RSK2, RPS6KA2/RSK3, RPS6KA6/RSK4, SYK, MKNK1/MNK1, MKNK2/MNK2, RPS6KA5/MSK1, RPS6KA4/MSK2, MAPKAPK3 or MAPKAPK5) and phosphatases (such as DUSP1, DUSP4, DUSP6 or DUSP16) are other substrates which enable the propagation the MAPK/ERK signal to additional cytosolic and nuclear targets, thereby extending the specificity of the cascade.

The activation of ERK1 by MEK1, subsequent slower phosphorylation of the flanking sites results in inhibition of the kinase. Because the T207 and Y210 phosphosites of ERK1 are highly conserved within the eukaryotic protein kinase family, hyperphosphorylation within the kinase activation T-loop may serve as a general mechanism for protein kinase down-regulation after initial activation by their upstream kinases. PMID: 26823016

Results show that miR-483-5p expression level is up-regulated in polycystic ovary syndrome patients and inversely correlated with notch3 and MAPk3 levels and that Notch3 and MAPK3 are the direct targets of MIR483. PMID: 25622783

Enhanced t-ERK1 expression in infiltrating lymphoid cells was significantly associated with female gender, absence of vascular and perineural invasion, lymph node metastases and early depth of invasion as well as with longer disease-free survival times PMID: 24682903

Expression of TMPRSS4 in gastric cancer is significantly associated with lymph node and distant metastasis, high Erk1 expression, and poor prognosis. PMID: 23922976

mp53 disrupts the role of ShcA in balancing the Smad-dependent and -independent signaling activity of TGF-beta and ShcA/ERK signaling is a major pathway regulating the tumor-promoting activity of TGF-beta PMID: 22039050

Imbalance in PRA/PRB ratio frequently associated with carcinogenesis might be a direct consequence of disorders in MAPK signaling. PMID: 21816898

It is suggested that since nuclear pERK1/2 can be mitogenic, it can serve as a reliable marker for the progression of ovarian cancer PMID: 21687944

the PI3K/PAK1/ERK signaling pathway has a role in LPA-stimulated breast cancer cell migration PMID: 21209852

Overall results proved downregulation of ERK1 by ubiquitin proteasomes and suppression of interaction between ERK1 and STAT1 as type I IFN antagonist function of SARS-CoV PLpro. PMID: 21270289

Study demonstrates a novel role of the ERK1/2 signaling pathway in promoting myocardium inflammation and dysfunction in coronary microembolization. PMID: 21150201

Both PAR2 and TLR4 activation on SW620 cells can trigger the phosphorylation of ERK1/2, regulate gene expression, and promote the proliferation and migration of cells. PMID: 21152870

Gene knockdown of ERK1 resulted in relocation of ATR from the nucleoplasm to the nucleolus in response to hydroxyurea, therefore making ATR unavailable to the sites of DNA damage. PMID: 20840867

Human cells from bronchus, intestine, and skin (keratinocytes)showed similar time patterns for the activation of mitogen-activated protein kinases Erk1/2 when treated with carbon nanoparticles. PMID: 20868224

Activation of the p44 MAPK pathway contributes to the underlying mechanism of IL-12 suppression by soluble CD40 ligand. PMID: 11937531

ERK1 activity ad dual-phosphorylation were undetectable in expanding and self-renewing hematopoietic progenitors (HP). Adding IL-3, inducing maturation and cell death in HP, led to sustained high levels of ERK1 activity and dual-phosphorylation. PMID: 12032872

Helicobacter pylori-induced ERK1 activation, especially by the cagA(+) strain, may play a protective role against gastric epithelial cell apoptosis partially through maintenance of bcl-2 gene expression PMID: 12540563

ERK1 is activated in a pathway that involves MKP1 and ubiquitin-proteasome PMID: 12676937

the active phosphorylated form of MAPK/ERK is aberrantly expressed in cultured and primary HD cells PMID: 12689928

Results suggest that receptor activator of NF-kappaB ligand (RANKL) induction by high extracellular calcium might not be mediated by the G protein-coupled calcium-sensing receptor, but by the p44/42 mitogen-activated protein kinase pathway. PMID: 12727216

Lipopolysaccharide-induced matrix metalloproteinase (MMP)-1 and MMP-9 production by monocytes is regulated by ERK1 through a mechanism involving the activation of additional MMP promoter sites via a PGE2-independent mechanism. PMID: 12794156