There are today 396 companies plus partners developing 509 TGF-beta receptor pathway targeting drugs in 1845 developmental projects in cancer. In addition, there are 2 suspended drugs and the accumulated number of ceased drugs over the last years amount to another 265 drugs. Tgf-Beta Receptor Signaling Pathway In Oncology Drug Pipeline Update lists all drugs and gives you a progress analysis on each one of them. Identified drugs are linked to 259 different targets. All included targets have been cross-referenced for the presence of mutations associated with human cancer. To date 252 out of the 255 studied drug targets so far have been recorded with somatic mutations. The software application lets you narrow in on these mutations and links out to the mutational analysis for each of the drug targets for detailed information. All drugs targets are further categorized on in the software application by 54 classifications of molecular function and with pathway referrals to BioCarta, KEGG, NCI-Nature and NetPath.

How May Drug Pipeline Update Be of Use?

Show investors/board/management that you are right on top of drug development progress in your therapeutic area. * Find competitors, collaborations partners, M&A candidates etc. * Jump start competitive drug intelligence operations * Excellent starting point for world wide benchmarking * Compare portfolio and therapy focus with your peers * Speed up pro-active in-/out licensing strategy work * Fast and easy way of tracking drugs using search engines; just one click from inside the application and you may search the World Wide Web and PubMed for any drug. Drug Pipeline Update is delivered to you as a downloadable application, which requires no installation on your computer. Please read more about application features and system requirements below.

Table of Contents

Drug Pipeline Update at a Glance

Investigators

Includes more than 396 principal companies plus their collaborators. There is direct access from inside the application to web pages of all principal companies.

Note: You are able to sort and find drugs according to companies and partners from drop-down menus in the application. You may also sort and find drugs according to country of companies.

Drug name & Synonyms

Lists commercial, generic and code names for drugs.

Developmental stage

This Drug Pipeline Update contains 509 TGF-beta receptor pathway targeting drugs in development, which have a total of 1845 developmental projects in cancer. In addition there are suspended and ceased drugs.

Pipeline Breakdown According to Number of Drugs

Marketed# 39

Registered# 1

Pre-registration# 3

Phase III# 41

Phase II# 170

Phase I# 187

Preclinical# 232

No Data# 18

Suspended# 2

Ceased# 265

Note: You are able to sort and find drugs according to developmental stage from drop-down menu in the application.

Indications

Included TGF-beta receptor pathway targeting drugs are also in development for 268 other indications, where of 159 are different cancer indications.

Note: You are able to find and sort drugs according to type of indication from drop-down menu in the application.

Targets

Mutations

All targets are cross-referenced with the Catalogue of Somatic Mutations in Cancer (COSMIC). It is designed to store and display somatic mutation information and related details and contains information relating to human cancers. To date 252 out of the 255 studied drug targets so far have been recorded with somatic mutations and the software application lets you narrow in on these mutations and links out to the mutational analysis for each of the drug targets for detailed information.

Biological Structures

The identity of available biological structures on 205 drug targets was retrieved from the RCSB Protein Databank for you to easily review the 4145 structures available today among drug targets.

Identified drugs are linked to more than 259 different targets, divided into 54 classifications of molecular function:

Antigen binding

ATPase activity

Binding

Catalytic activity

Cell adhesion molecule activity

Chaperone activity

Chromatin binding

Cysteine-type peptidase activity

Cytokine activity

Deacetylase activity

DNA binding

DNA topoisomerase activity

Extracellular matrix structural constituent

G-protein coupled receptor activity

Growth factor activity

GTPase activity

Heat shock protein activity

Isomerase activity

Kinase activity

Kinase binding

Kinase regulator activity

Ligand-dependent nuclear receptor activity

Ligase activity

Lipid kinase activity

Lipid phosphatase activity

Metallopeptidase activity

Molecular function unknown

Oxidoreductase activity

Peroxidase activity

Protease inhibitor activity

Protein binding

Protein serine/threonine kinase activity

Protein serine/threonine phosphatase activity

Protein threonine/tyrosine kinase activity

Protein tyrosine/serine/threonine phosphatase activity

Protein-tyrosine kinase activity

Receptor activity

Receptor binding

Receptor signaling complex scaffold activity

Receptor signaling protein serine/threonine kinase activity

RNA binding

RNA-directed DNA polymerase activity

Serine-type peptidase activity

Signal transducer activity

Structural constituent of cytoskeleton

Superoxide dismutase activity

Transcription factor activity

Transcription regulator activity

Transferase activity

Translation regulator activity

Transmembrane receptor activity

Transmembrane receptor protein tyrosine kinase activity

Transporter activity

Ubiquitin-specific protease activity

Sub-Cellular Localization

Identified targets are categorized into 32 different primary and alternate sub-cellular localizations:

Basolateral membrane

Cell junction

Centrosome

Chromosome

Clathrin-coated vesicle

Cytoplasm

Cytoplasmic vesicle

Cytoskeleton

Cytosol

Endoplasmic reticulum

Endosome

Extracellular

Extracellular matrix

Focal adhesion

Golgi apparatus

Integral to membrane

Kinetochore

Lysosome

Microtubule

Mitochondrial membrane

Mitochondrion

Nuclear membrane

Nucleolus

Nucleoplasm

Nucleus

Perinuclear region

Perinuclear vesicle

Peroxisome

Plasma membrane

Ribosome

Sarcoplasmic reticulum

Secreted

Note: You are able to find and sort drugs according to target gene name, protein name, molecular function of target, target localization, presence of mutations and availability of biological structures of target from drop-down menus in the application.

Target Expression Profile

Direct links are provided from inside the application to 389 protein expression profiles of 239 drug targets in various human tissues and cancer types, cell lines and primary cells, including up to:

48 different normal tissue types

20 different types of cancer

47 cell lines

12 samples of primary blood cells

Pathway Referals

Identified targets have been cross referenced against their involvement in different cellular pathways, according to BioCarta, KEGG, NCI-Nature and NetPath.

BioCarta# 241 Pathways

KEGG# 184 Pathways

NCI-Nature# 256 Pathways

NetPath# 32 Pathways

Note: You are able to find and sort drugs according to targeted pathways from drop-down menus in the application.

Mechanism

In total there are different drug mechanism of action represented in this Drug Pipeline Update.

Note: You are able to find and sort drugs according to mechanism of action from drop-down menu in the application.

Compound

Identified drug compounds are described by:

Compound type, Chemical name, CAS Number and molecular weight

Note: You are able to sort and find drugs according to compound type from drop-down menu in the application.

Drug Profile

Progress analysis and review of drug development. A typical drug profile reports on, depending on stage of development and available information:

Described target(s) is/are presented with primary and alternate localizations.

Target Expression Profiles

Links to protein expression profile(s) of target(s) in various human tissues, cell lines and primary cells, including up to:

48 different normal tissue types

20 different types of cancer

47 cell lines

12 samples of primary blood cells

Mutation

All targets are cross-referenced with the Catalogue of Somatic Mutations in Cancer (COSMIC). It is designed to store and display somatic mutation information and related details and contains information relating to human cancers.

Biological Structures

The identity of available biological structures on drug targets was retrieved from the RCSB Protein Databank for you to easily review what available structures of drug targets exist.

Targeted Pathways

Described target(s) is/are matched for the involvement in cellular pathways according to BioCarta, KEGG, NCI-Nature and NetPath.

Mechanism

Drug mechanism of action

Developmental Projects

Summary field of developmental projects for the drug, including indication, developmental stage and status.

Example:

Cancer, myeloma - Phase II Clinical Trial - Active

Cancer, prostate - Phase III Clinical Trial - Ceased

Drug Description

Short introduction to drug

Compound Data

Compound type, Chemical name, CAS Number and molecular weight

Patent Data

Available patent information related to the drug is presented here.

Fillings and Approvals

Approvals and submissions

Analyst comments

Deals & Licensing

Collaborations and deals

Availability for licensing

Phase IV Data

Available Phase IV development data, developmental history and scientific data.

Phase III Data

Available Phase III development data, developmental history and scientific data.

Phase II Data

Available Phase II development data, developmental history and scientific data.

Phase I Data

Available Phase I development data, developmental history and scientific data.

Phase 0 Data

Available Phase 0 development data, developmental history and scientific data.

Preclinical Data

Available preclinical development data, developmental history and scientific data.

Discovery Data

Available discovery development data, developmental history and scientific data.

Application Features

Search, Find and Filter Panel with Initial Result Presentation

With this panel you can define your selectivity in each drug search with up to 24 different drug specific parameters. Each parameter has multi-select options to them and can be used as either an inclusion parameter or exclusion parameter.

The initial result table is a dynamic sortable table which gives you a fast overview of found results and can be narrowed down further by your own additional keywords.

Direct linkage from inside the application to related internet resources

Our dynamic report generator lets you with ease and speed generate html reports directly in your web browser (Internet Explorer and FireFox), whether it is a single drug profile or an entire search you want have a report of.

System Requirements

Operating system: Windows (2000/XP/Vista/7/8) for Mac Users the service is only available online