Medicni perspektivi (Medical perspectives)http://journals.uran.ua/index.php/2307-0404
<p><span><strong>Journal "<strong>Medicni perspektivi" (Medical perspectives) </strong></strong></span><span>has been published since the year 1996, since the year 1999 has been attested by Higher Attestation Committee (HAC) of Ukraine as special edition (</span><span>N 261 from 06.03.2015)</span>, ISSN 2307-0404.</p><p>Founder: SE "Dnipropetrovsk medical academy of Health Ministry of Ukraine".</p><p>Certificate on registration: series KV№1721 from 24.10.1995 given on behalf of decision of editorial board, editorial councel of SI "Dnipropetrovsk medical academy of Health Ministry of Ukraine".</p><p>Journal has been registered in International databases: Russian Science Citation Index (RSCI), "RISTI" (Russia, Moscow), Ulrich's Periodicals Directory, journal "Dzherelo" of institute of problems of information registration of NAS of Ukraine, National Library named after V.I. Vernadsky, EBSCO, ProQuest (<span lang="RU">Health &amp; Medical Collection</span>), DOAJ and others.</p><p>Frequency – 4 times per year.</p><p><a href="http://medpers.dsma.dp.ua/" target="_blank">http://medpers.dsma.dp.ua/</a></p><p>Editorial stuff: </p><p>Editor-in-chief of "Medicni perspektivi" journal - Tetiana Pertseva</p><p>Scientific editor - Vitaly Mamchur</p><p>Editor - Eleonora Biletska</p><p>Literary editors: M.Yu. Sydora, I.M. Klymenko<br /> Design and model: L.M. Hryhorchuk<br /> Bibliographer: R.M. Hodlevska<br /> Secretary: V.V. <span>Kalinicheva</span></p><p>Subscription index: 40512</p><p>Contacts: Editors office "Medicni perspektivi" <br /> 9, <span>Vernadsky </span>str., <br /> Dnipro, 49044 Ukraine<br /> ph. 38(0562)31-22-78<br /> E-mail: <a href="mailto:medpers@dma.dp.ua"><strong>medpers@dma.dp.ua</strong></a></p>en-US<p><span>Submitting manuscript to the journal "Medicni perspektivi" the author(s) agree with transferring copyright from the author(s) to publisher (including photos, figures, tables, etc.) editor, reproducing materials of the manuscript in the journal, Internet, translation into other languages, export and import of the issue with the author’s article, spreading without limitation of their period of validity both on the territory of Ukraine and other countries. This and other mutual duties of the author and all co-authors separately and editorial board are secured by written agreement by special form to use the article, the sample of which is presented on the site.</span><span><br /></span></p><p><span>Author signs a written agreement and sends it to Editorial Board simultaneously with submission of the manuscript.</span></p><p> </p>medpers@dma.dp.ua (Eleonora Biletska)medpers@dma.dp.ua (Eleonora Biletska)Thu, 04 May 2017 13:59:58 +0300OJS 2.4.4.1http://blogs.law.harvard.edu/tech/rss60Main theoretical, pathophysiological and practical aspects of neuroplasticity.http://journals.uran.ua/index.php/2307-0404/article/view/100856
Results of the state-of-the-art review of the "neuroplasticity" term development and new data about the sanogenetic, pathophysiological, neurophysiological, bio - and neurochemical bases of the nervous system recovery processes are given in this article. Key mechanisms of adaptive, desadaptive, responsive and cross modal forms of neuroplasticity within primary and secondary neuroplasticity are distinguished. The specific character of neurogenesis and functional reorganization of neuronets in specific regulatory structures of the brain in the norm and pathogenesis are outlined. Controversies about functional and morphological aspects of neuroplastic processes are presented. Application-oriented methods of neuroplasticity study are considered and systemically classified. Clinical diagnostics with the specified neu­rovisualization, neurochemical, neurophysiological criteria and coefficients is considered also. Specific methods of neurorehabilitation and perspective urgent directions of neuro- sanogenesis are designated using physical, reflex, neuropsychological, behavioural brain stimulation methods and pharmacological therapy.А. V. Pogorelov, Yu. V. Bukreyeva, О. А. Gavva, V. І. Pashkovsky, О. М. Tolubayev, Е. К. Dukhovenkohttp://journals.uran.ua/index.php/2307-0404/article/view/100856Tue, 04 Apr 2017 00:00:00 +0300Phytotherapeutic drugs with nephroprotective activity (review).http://journals.uran.ua/index.php/2307-0404/article/view/100866
<p class="1">The article analyzes characteristics of chemical composition and pharmacodynamics of phytotherapeutic agents (<span class="alt-edited"><span lang="EN">monopreparations</span></span> and complexes), used in the treatment of kidney and urinary tract diseases.<span lang="EN-US"> A</span>nalysis of main pharmacological effects of medicinal plants and their complexes<span lang="EN-US"> was made</span>, comparative characteristics of herbal remedies by indications for use in acute and chronic diseases of the kidneys and urinary tract (pyelonephritis, cystitis, urethritis, glomerulonephritis, nephrolithiasis) and edematous syndrome of various etiologies was carried out. Pharmacological characteristics of diuretic, nephroprotective and<span class="alt-edited"><span lang="EN"> nephrolitholytic</span></span> action <span class="alt-edited"><span lang="EN">of </span></span>watermelon <span class="alt-edited"><span lang="EN">lyophilized powder</span></span> according to its composition (flavonoids, macro- and micronutrients, vitamins and so on.) was analyzed. On the basis of data on a wide range of biological activity, sufficient clinical efficacy as adjuvant therapy drugs, as well as good tolerability of herbal remedies, <span class="alt-edited"><span lang="EN">appropriateness and</span></span> prospects of <span class="alt-edited"><span lang="EN">search for new</span></span> plant nephroprotective drugs<span class="alt-edited"><span lang="EN"> was concluded</span></span>.</p>E. A. Podpletnyaia, N. V. Khomiak, E. V. Sokolova, S. P. Kaydash, E. V. Khomiakhttp://journals.uran.ua/index.php/2307-0404/article/view/100866Tue, 04 Apr 2017 00:00:00 +0300Practice of implementation of innovative means of teaching in forming of preventive thinking in students of higher medical educational establisments.http://journals.uran.ua/index.php/2307-0404/article/view/100868
The problem of construction of a holistic methodological system of training future doctors considered in the article, is impossible outside the context of integration processes taking place in modern education and needs a careful study of international experience. The research aim is to develop a system of innovative means of education for the formation of preventive thinking in students of higher medical educational establishment, concerning professionally oriented undergraduate preparation of doctors. Analysis of the results allowed to determine the characteristic features of innovative means, forms and teaching methods, specificity of their use in interactive educational environment, this against the background of meticulous work of the teaching staff of the department of general hygiene of Dnepropetrovsk Medical Academy provides the efficiency of educational process which integrates personal, creative, social and educational purposes. The suggested innovative methods are involved in the general system of modern education in higher school being effectively used for providing a high level of professional training in teaching of academic subject area "Hygiene and Ecology".E. M. Biletska, T. A. Holovkova, O. V. Antonovahttp://journals.uran.ua/index.php/2307-0404/article/view/100868Tue, 04 Apr 2017 00:00:00 +0300A comparative evaluation of the antimicrobial activity of local antiseptics in revision hip arthroplasty.http://journals.uran.ua/index.php/2307-0404/article/view/100870
<p class="1">In our study <span lang="EN-US">there </span>is presented information <span lang="EN-US">on</span> the research <span lang="EN-US">of</span> antagonistic activity of medications octenidine, decamethoxine, dioxydine, myramistin, povidone-iodine, chlorhexidine in standard dosage form and in dilution (1:1 and 1:5) on microorganisms: S. aureus, S. epidermidis, S. haemolitycus, P. aeruginоsa, E. agglomerans, E. coli <span lang="EN-US">isolated</span> from patients <span lang="EN-US">in</span> revision hip arthroplasty. <span lang="EN-US">A</span> considerable bacrteriostatic and bacreticidal activity of investigated medications <span lang="EN-US">on</span> microorganisms was shown. The investigation <span lang="EN-US">of </span>antagonistic activity of medications was conducted by the “well” method according to methodological guidelines <span lang="EN-US">for</span> experimental (pre-clinical) investigation of medic<span lang="EN-US">inal</span> product<span lang="EN-US">s</span>for local treatment of purulent wounds. As<span lang="EN-US"> </span>a solid nutrient solution <span lang="EN-US">there </span>was used Mueller-Hinton agar, <span lang="EN-US">in</span> which we made cavities <span lang="EN-US">with </span>diameter <span lang="EN-US">of </span>8 mm <span lang="EN-US">where</span> experimental medications (0,01 ml) were put<span lang="EN-US">.</span> As experimental test-cultures <span lang="EN-US">there </span>were used main clinical strains of microorganisms (S. aureus, S. epidermidis, S. haemolitycus, P. aeruginоsa, E. agglomerans, E. coli) <span lang="EN-US">isolated</span> from patients, receiving treatment in the department of orthopaedics <span lang="EN-US">N </span>2, I.I. Mechnikov regional clinical hospital. 0.9% physiologic saline was used <span lang="EN-US">a</span>s a control. <span lang="EN-US">C</span>hlorhexidine, octenidine, dioxydine, decamethoxine and povidone-iodine undiluted and in dilution 1:1, <span lang="EN-US">cause</span><span lang="EN-US">b</span>actericidal effect on staphylococcus<span lang="EN-US">,</span> in dilution 1:5 <span lang="EN-US">–</span> bacteriostatic effect. Myramistin has practically no effect on staphylococcus. Dioxydine and octenidine in initial dilution have a steady bactericidal effect on E. coli and P. aeruginosa and in dilution 1:1 only dioxydine has bactericidal effect. Chlorhexidine and povidone-iodine have bacteriostatic effect on E.coli and P. aeruginosa. In dilution 1:5 only dioxydine has <span lang="EN-US">a </span>bactericidal effect on E. coli and P. aeruginosa. For E. agglomerans only dioxydine in standard dosage form and in dilution 1:1 and 1:5 has bactericidal effect 36mm, 33mm and 25 mm accordingly. But octenidine in <span lang="EN-US">a </span>standard dosage form has bactericidal effect on E. agglomerans and in dilution 1:1 – bacteriostatic. Other medications have no effect on E. agglomerans. Antimicrobal effect in <span lang="EN-US">a </span>standard dosage form on the greatest amount of experimental microorganisms strains <span lang="EN-US">was</span><span lang="EN-US">in </span>octenidine and dioxydine; in dilution 1:1 – <span lang="EN-US">in </span>octenidine and dioxydine on enterobacteria, on staphylococc<span lang="EN-US">i</span> – chlorhexidine, octenidine and dioxydine; in dilution 1:5 – the maximal effect on enterobacteria <span lang="EN-US">was in</span> dioxydine and on staphylococc<span lang="EN-US">i in</span> chlorhexidine.</p>A. E. Loskutov, A. V. Digtiar, D. A. Stepanskiyhttp://journals.uran.ua/index.php/2307-0404/article/view/100870Tue, 04 Apr 2017 00:00:00 +0300A comparative characteristics of patients with acute coronary syndrome according to data of Ukrainian and European registers 2009-2015.http://journals.uran.ua/index.php/2307-0404/article/view/100871
<p class="1">The aim of this work was to compare basic anamnestic and demographic data in Ukrainian and European groups included in <span lang="EN-US">the </span>register SNAPSHOT 2009 and local group <span lang="EN-US">of</span><span lang="EN-US">the </span>year2015. <span lang="EN-US">It was</span><span lang="EN-US">established that by the year</span>2015 patients<span lang="EN-US">’</span> age advanced (from 65±13 <span lang="EN-US">to </span>68.6±11.2 y<span lang="EN-US">ea</span>rs), <span lang="EN-US">as well as </span>part of women (from 30% t<span lang="EN-US">o</span> 47.5%), previous myocardial infarction frequency (from 22% t<span lang="EN-US">o</span> 34.7%), heart failure (from 10% t<span lang="EN-US">o</span> 42.6%), and chronic kidney disease (from 2% t<span lang="EN-US">o</span> 14.9%). The increase of prevalence of arterial hypertension (88.1%) in local group was founded. The average body mass index had tendency to increasing (28.6±4.4 kg/m<sup>2</sup>); the part of patients with increase<span lang="EN-US">d</span> body mass index was equal among men and women. Simultaneous increase of such comorbidities as arterial hypertension, chronic kidney disease and complications <span lang="EN-US">of</span> previous myocardial infarction and heart failure in the local register with a lower prevalence of such risk factors as smoking (13.9%), dyslipidemia (10.9%), and frequency of diabetes (10.9%) were founded. The prevalence of peripheral atherosclerosis was lower in <span lang="EN-US">the </span>year 2015 research group than in European one (1% vs 6%). The prevalence of percutaneous coronary intervention (3.1%) and CABG (1.1%) for diagnostic and treatment of ischemic heart disease was extremely low in 2015 year group. The prevalence of previous stroke and chronic obstructive pulmonary disease remained approximately <span lang="EN-US">the same</span><span lang="EN-US">in</span> all registers groups. The tendency of increase of malignancy prevalence in anamnesis was founded (5.9%), and probably <span lang="EN-US">it </span>was associated with increas<span lang="EN-US">e</span> of average patients’ age.</p>O. S. Shchukina, O. A. Kovalhttp://journals.uran.ua/index.php/2307-0404/article/view/100871Tue, 04 Apr 2017 00:00:00 +0300Modeling systemic autoimmune rheumatic disease in rats under the adverse weather conditions.http://journals.uran.ua/index.php/2307-0404/article/view/100896
<p class="1">Changes in the lungs, heart and kidneys are found in all animals with experimental systemic autoimmune rheumatic disease and respectively <span lang="EN-US">in </span>47%, 47% and 40% of cases of intact rats in a hostile environment with xenobiotics air pollution (ammonia + benzene + formalin), <span lang="EN-US">herewith</span> in every third or fourth individual lesions of visceral vessels developed. The negative environmental situation increases the frequency of morphological signs of the disease, <span lang="EN-US">such </span>as proliferation of endothelial vessels of the heart by 68% and renal arterioles by 52%, in addition, there are direct correlations <span lang="EN-US">of </span>angiopathy degree in individual organs<span lang="EN-US">;</span><span lang="EN-US">t</span>h<span lang="EN-US">is</span> depend<span lang="EN-US">s</span> on the nature of pathological process modeling and demonstrates air pollution as a risk factor <span lang="EN-US">of</span> disease in humans. <span lang="EN-US">T</span>he impact of pulmonary vessels sclerosis on the development of bronhosclerosis, perivascular infiltration of the heart muscle on the lymphocyte-macrophage infiltration of the stroma of the myocardium and sclerosis of renal arterioles on the degree of nephroslerosis of stroma<span lang="EN-US"> is</span><span lang="EN-US">d</span>irectly associated, with the model of systemic autoimmune rheumatic diseases whereas air pollution by xenobiotics determines dependence<span lang="EN-US">s</span> of the degree <span lang="EN-US">of </span>cellular infiltration of alveolar septa <span lang="EN-US">from</span> perivascular pulmonary infiltration, the development of cardiomyocytes hypertrophy <span lang="EN-US">from</span> proliferation of the heart endothelial vessels, increase <span lang="EN-US">of</span> kidney mesangial matrix <span lang="EN-US">from </span>the proliferation of endothelial glomerular capillaries.</p>Ye. D. Yegudina, О. V. Synyachenko, О. О. Khanyukov, V. І. Suiarko, G. S. Тaktashovhttp://journals.uran.ua/index.php/2307-0404/article/view/100896Tue, 04 Apr 2017 00:00:00 +0300The comparative characteristic of extra- and intracranial hemodynamics in patients with traumatic brain injury in the long-term period.http://journals.uran.ua/index.php/2307-0404/article/view/100898
<p class="1">Traumatic brain injury (TBI) remains an actual problem of modern medicine, as well as <span lang="EN-US">of</span> economic and social sectors. Vascular factor plays a leading role in forming of the clinical presentation of the disease in the long-term period of TBI. The aim of the study was to clarify the characteristics of hemodynamic changes at different levels of cerebral blood supply (main extra- and intracranial arteries and level of cerebral vessels) depending on the severity of TBI. We examined 100 patients in the long-term period of mild, moderate and severe TBI. All patients underwent rheoencephalography, ultrasound duplex scanning of the main arteries of the head and neck with transcranial dopplerography and functional test with visual load. Extracranial vascular changes in the long-term period of TBI are characterized by significant increase of carotid intima-media thickness and the diameters of right internal carotid artery and left internal carotid artery <span lang="EN-US">together </span>with the severity of TBI. The qualitative analysis of linear blood flow velocity reveals the decrease in the number of patients with a compensatory reaction in the form of <span lang="EN-US">its</span> acceleration in the middle cerebral artery with increasing TBI severity <span lang="EN-US">but</span> the number of patients with reduced linear blood flow velocity<span lang="EN-US"> increases</span>. Abnormal autoregulation of the cerebral circulation and reduction of vascular reactivity was established <span lang="EN-US">in</span> the <span lang="EN-US">majority</span><span lang="EN-US">of </span>patients of all groups. In addition, the incidence of vascular disturbances increased from 1<sup>st</sup> to 3<sup>rd</sup> group. According to the results of rheoencephalography, we detected prevailing spastic changes of the curve in all groups of patients. The degree of disturbances manifestations increase<span lang="EN-US">s</span> with the severity of TBI.</p>V. M. Shkolnyk, H. D. Fesenko, O. V. Soyahttp://journals.uran.ua/index.php/2307-0404/article/view/100898Tue, 04 Apr 2017 00:00:00 +0300Medicaments administration into the subtenon eye space in treatment of anterior ischemic neuropathy.http://journals.uran.ua/index.php/2307-0404/article/view/100899
<p class="1"><span>In spite of treatment provided </span><span lang="EN-US">in</span>anterior<span class="apple-converted-space"><span lang="EN-US"> </span></span><span>ischemic</span><span class="apple-converted-space"><span lang="EN-US"> </span></span><span>neuropathy, a prognosis for visual</span><span class="apple-converted-space"><span lang="EN-US"> </span></span><span>functions is poor and depends on severity </span><span lang="EN-US">of </span><span>affect</span><span lang="EN-US">ion of</span><span>vascular system of </span><span lang="EN-US">the </span><span>body. We have studied the exposure to cortexin</span><span class="apple-converted-space"><span lang="EN-US"> </span></span><span>and</span><span class="apple-converted-space"><span lang="EN-US"> </span></span><span>diprospan </span><span lang="EN-US">in</span><span> subtenon </span><span lang="EN-US">administration</span><span> on the eye hemodynamics in 18 patients experiencing </span>anterior<span> ischemic neuropathy(18</span><span class="apple-converted-space"><span lang="EN-US"> </span></span><span>eyes) </span><span lang="EN-US">who </span><span>have been treated operatively (</span><span lang="EN-US">administration</span><span> of </span><span class="apple-converted-space"><span lang="EN-US">cortexin </span></span><span>and</span><span class="apple-converted-space"><span lang="EN-US"> </span></span><span>diprospan into the subtenon space of the </span><span lang="EN-US">affected</span><span> eye) against the background of complex conservative prevention. The control group was constituted of 16 patients (16 eyes) </span><span lang="EN-US">who </span><span>have not been treated operatively. As a result of provided treatment the patients of the basic group showed </span><span lang="EN-US">increase </span><span>of vision</span><span lang="EN-US"> acuity</span><span>, </span><a href="http://www.multitran.ru/c/m.exe?t=5621923_1_2&amp;s1=%E3%F0%E0%ED%E8%F6%FB%20%EF%EE%EB%FF%20%E7%F0%E5%ED%E8%FF"><span>field of view limits</span></a><span> and eye ground </span><span lang="EN-US">state</span><span>. </span></p>V. N. Sakovich, E. M. Grechka, M. E. Stepakhina, Е. А. Derbina, N. V. Guzenkohttp://journals.uran.ua/index.php/2307-0404/article/view/100899Tue, 04 Apr 2017 00:00:00 +0300Dynamics of parameters of ultrasonic, microbiological and cytological investigations in the treatment of postoperative wound complications using magnesium containing minerals in the elderly patients.http://journals.uran.ua/index.php/2307-0404/article/view/100902
<p class="1">57 patients aged over 60 years with various types of wound complications after surgery for abdominal and anterior abdominal wall<span lang="EN-US"> were treated</span>. Treatment of wound complications included both traditional methods and the use of packs of bishofit. О<span lang="EN">n the third day after the start of treatment there was a significant decrease in almost all computing performance indices as compared with treatment using bishofit. On the day 7 a noticeable difference of wound cavity width by 62.88%, the volume of the wound cavity by 85.76% in patients of the second group as compared with patients of the first was noted. </span>So<span lang="EN-US">,</span><span lang="EN">bishofit use in the form of compresses in the treatment of postoperative wound complications such as hematoma, seroma and infiltration leads to a significant reduction in wound exudation, rapid decline in the concentration of microorganisms in the wound; this reduces time of wounds healing and patients’ recovery.</span></p>S. O. Muntyan, A. Y. Nosov, V. V. Getman, K. P. Balash, S. P. Chernyak, N. L. Kruglyakhttp://journals.uran.ua/index.php/2307-0404/article/view/100902Tue, 04 Apr 2017 00:00:00 +0300Histomorphological features of combined forms of tuberculosis and lung cancer.http://journals.uran.ua/index.php/2307-0404/article/view/100904
<p class="1"><span lang="EN-US">The were s</span>tudied pathological features <span lang="EN-US">of </span>combined forms of tuberculosis and non-small cell lung cancer in 72 patients who underwent radical surgical resection intervention<span lang="EN-US">s</span><span lang="EN-US">from </span>transsternal access with mediastinal lymph node dissection, <span lang="EN-US">with pre</span>domina<span lang="EN-US">nce</span><span lang="EN-US">of</span> pneumonectomy - 63.9%. <span lang="EN-US">There were</span> identified three main categories of pathological changes: cancer on the background of post-tuberculosis changes<span lang="EN-US">,</span> cancer <span lang="EN-US">in </span>tuberculoma, cancer in the wall of the active cavity. Post-tuberculosis changes were presented <span lang="EN-US">by </span>dense centers, fibrosis, cirrhosis areas, sanitized cavities with histological predominance of coarse fiber connective tissue with giant<span lang="EN-US"> cell</span>granulomas, with areas characterized by the appearance of the lung tissue with atypical proliferation and metaplasia <span lang="EN-US">of </span>bronchopulmonary epithelium, which is a precancerous condition. This malignant tumor process was <span lang="EN-US">presented</span> mainly <span lang="EN-US">by </span>adenocarcinomas and squamous cell cancer and <span lang="EN-US">differred by</span> polymorphic macro- and microscopic picture. Cancer<span lang="EN-US"> in</span>tuberculoma and fibrous wall cavity differed <span lang="EN-US">by </span>pronounced activity of tuberculosis process in the form <span lang="EN-US">of </span>lymphohistiocytic infiltration<span lang="EN-US">,</span> foci of caseous necrosis and presence of expressed granulation layer of Pirogov<span lang="EN-US">-</span>Langhans<span lang="EN-US">’</span>cells. The basic morphological causes of carcinogenesis due to secondary changes of lung tissue in patients with tuberculosis<span lang="EN-US"> were determined</span>. The features of metastasis of malignant tumors on the background of specific tubercul<span lang="EN-US">ous</span> and post-tuberculosis changes in regional lymph nodes and the interrelation between the frequency of metastatic lesions with severity <span lang="EN-US">of </span>tuberculosis and post-tuberculosis changes <span lang="EN-US">in</span> them <span lang="EN-US">were studied; this</span> ha<span lang="EN-US">s</span> clinical significance in the surgical treatment of patients with concomitant forms of tuberculosis and lung cancer.</p>Y. F. Savenkov, Y. F. Koshak, I. A. Malcev, I. V. Korpusenko, P. E. Bakulinhttp://journals.uran.ua/index.php/2307-0404/article/view/100904Tue, 04 Apr 2017 00:00:00 +0300Features of the mental status of patients with community-acquired pneumonia, combined with a chronic pathology of the hepatobiliary system of non-viral genesis.http://journals.uran.ua/index.php/2307-0404/article/view/100906
<p class="1">The aim was <span lang="EN-US">to</span> study the characteristics of mental status of patients with community-acquired pneumonia (CAP), combined with a chronic pathology of the hepatobiliary system of non-viral genesis. We observed 165 patients with CAP in the age of 25-57 years. All patients were divided into two representative groups: I group (68 patients) <span lang="EN-US">– </span>CAP was comorbid with hepatic steatosis (HS), II group (96 patients) with absence of chronic liver disease. To evaluate the psychological profile of patients<span lang="EN-US">’ personality</span> we used a standardized multivariate method of personality research and to evaluate the level of anxiety and depression the scale of Spielberger-Hanin test and Beck’s questionnaire were used. Results of the study revealed that 66.2% of patients with CAP, comorbid with HS<span lang="EN-US">,</span> declared the formation of psycho-emotional disorders <span lang="EN-US">in the form of</span> neurotic reactions to the disease with prevalence of hypochondria, depression, hysterical manifestations with high psychasthenia, trait anxiety and somatic reactions with prevalence of anxiety and emotional instability, lots of somatic complaints, fixation on their own condition with formation of distinctive thinking mode and behavior <span lang="EN-US">by</span> the type of "f<span lang="EN-US">l</span>ight into disease". <span lang="EN-US">After completion of the standard treatment of patients with CAP, combined with HS, 42</span>,<span lang="EN-US">7% of patients had psycho-emotional disorders, which were moderately expressed. Thus, in the complex of treatment and rehabilitative measures in patients with CAP, combined with HS some characteristics of the psychological profile, in the form of psycho-neurotic reaction to the disease should be considered to take optimal corrective actions.</span></p>R. V. Razumnyi, I. D. Spirinahttp://journals.uran.ua/index.php/2307-0404/article/view/100906Tue, 04 Apr 2017 00:00:00 +0300Muscle dysfunction in tension-type headache in adolescents and methods of its correction.http://journals.uran.ua/index.php/2307-0404/article/view/101420
The aim of our study was to investigate the value of myofascial disorders in adolescents with tension-type headaches and evaluation of effectiveness of their treatment using non-drug therapies. A total of 320 adolescents with tension-type headache have been under study. Research of intensity of headache and pain muscle dysfunction was performed. The treatment period was 1 month. We compared treatment by individual adaptive biofeedback based on heart rate variability and pharmacotherapy. Also patients performed the complex of techniques of isometric muscle autocorrection. It was established that with the increase of incidence of headache episodes, the intensity of the local muscle tenderness and the number of muscles, involved in the formation of a painful syndrome increases. Usage of individual adaptive biofeedback was more effective in reducing the severity of muscle dysfunction, than usage of pharmacotherapy, especially in patients with chronic tension-type headache.K. A. Stepanchenkohttp://journals.uran.ua/index.php/2307-0404/article/view/101420Tue, 04 Apr 2017 00:00:00 +0300Clinical-anamnestic features and quality of life in women with endometrial pathology on the background of uterine myoma.http://journals.uran.ua/index.php/2307-0404/article/view/101424
<p class="1">A total of 325 women 35-55 years old suffering from various forms of endometrial pathology<span lang="EN-US"> were examined</span>. It was found that 110 (33.8%) patients ha<span lang="EN-US">d</span> combination of endometrial pathology and uterine myoma. They <span lang="EN-US">made up</span> the main group (group MM)<span lang="EN-US">,</span> the reference group consisted of 215 women without uterine myoma (group K). It <span lang="EN-US">was</span> established that group <span lang="EN-US">with</span> uterine myoma is characterized by increased extragenital <span lang="EN-US">morbidity</span>: cardiomyopathy (p&lt;0.009), hypertension (p&lt;0.03), obesity stage III-IV (p&lt;0.006), iron-deficiency anemia (p&lt;0,02), vegetative-vascular dystonia (p&lt;0,03) and nervous system diseases (p&lt;0,01) <span lang="EN-US">were</span> significantly more common<span lang="EN-US">.</span> The presence of uterine myoma is associated with increased risk of recurrence of endometrial hyperplasia and polyps. These data suggest that <span lang="EN-US">in </span>the pathophysiology of uterine myoma in women of late reproductive and premenopausal age with endometrial pathology somatic and somatoform disorders play a more significant role than concomitant or previous genital pathology. <span lang="EN-US">In late reproductive age and menopause period e</span>ndometrial lesions <span lang="EN-US">are </span>combined with uterine myoma <span lang="EN-US">in </span>every third patient. <span lang="EN-US">S</span>omatic factors have a greater impact <span lang="EN-US">on t</span>he development of uterine myoma than reproductive. The presence of uterine myoma is an additional criterion of reduc<span lang="EN-US">e</span><span lang="EN-US">of</span> quality of life and burdens the prognosis of treatment of endometrial pathology in late reproductive age and premenopausal<span lang="EN-US"> period</span>.</p>V. L. Dronova, S. M. Kornienkohttp://journals.uran.ua/index.php/2307-0404/article/view/101424Tue, 04 Apr 2017 00:00:00 +0300Evaluation of clinical efficacy of a combined analgetic drug "Fanigan" for symptomatic treatment of patients with pain syndrome of various genesis.http://journals.uran.ua/index.php/2307-0404/article/view/101433
<p class="1">The authors studied the efficacy of combined drug <span lang="EN-US">Fanigan</span> (paracetamol 500 mg and diclofenac sodium 50 mg) (production of "Kusum Pharm" (Ukraine) or "Kusum <span lang="EN-US">Heltker</span> PVT. LTD" (India) <span lang="EN-US">in </span>tablets for symptomatic treatment of patients with pain syndrome. <span lang="EN-US">A </span>pronounced clinical efficiency of its application in patients with pain syndrome of various <span lang="EN-US">g</span>enesis in a daily dose from 2 to 3 tablets for 3 to 7 days <span lang="EN-US">was e</span>stablished. The obtained data on the clinical <span lang="EN-US">efficacy </span>of the drug<span lang="EN-US">.</span> Fanigan in the treatment of patients with pain syndrome of various <span lang="EN-US">g</span>enesis allow to recommend it for application in wide clinical practice.</p>V. Y. Mamchur, S. V. Nalotov, D. S. Nosivets, V. I. Palamarchuk, V. G. Guryanov, A. J. Ogolhttp://journals.uran.ua/index.php/2307-0404/article/view/101433Tue, 04 Apr 2017 00:00:00 +0300Assessment of social losses of pollution's health caused by man-made pollution of atmospheric air with emissions of particulate matters (PM10).http://journals.uran.ua/index.php/2307-0404/article/view/101436
According to available estimates, about 3% of lethal outcomes from cardiac-pulmonary pathology and 5% from lung cancer are related to the impact of patriculate matters (PM). In the course of the study there were assessed social losses of population’s health (additional death cases) caused by risk conditions of atmospheric air pollution with PM of various air-dynamic diameter (PM<sub>10</sub>), proper to emissions of various industrial enterprises. It was established that 90% of population of cities under study live under high exposures (≥50 µg/m<sup>3</sup>) health and risks for population (IRM=10<sup>-3</sup>÷10<sup>-4</sup>), caused by PM<sub>10</sub>emissions. Results showed that metallurgical industry is responsible for 7,2 to 2193 additional mortality cases. The impact of machine building enterprises – from 0.06 to 21 cases; coke and chemical – from 1.5 to 36 cases; mining – from 1.1 to 14,6 cases. The findings revealed 0.6 % increase in lifetime mortality for each 10 µg/m<sup>3</sup> in 24-hour average PM<sub>10</sub> concentration. Based on research outcomes, a set of instruments was developed for implementation of air pollution risk management programs aimed at mitigation of health risks from (PM<sub>10</sub>) in highly exposed groups.Ye. I. Turos, A. A. Petrosian, A. N. Davidenkohttp://journals.uran.ua/index.php/2307-0404/article/view/101436Tue, 04 Apr 2017 00:00:00 +0300Study of embryotoxic effects of intranasally administred desloratadine on laboratory animals.http://journals.uran.ua/index.php/2307-0404/article/view/101437
<p class="1"><span lang="EN-US">The</span> study was conducted to detect possible changes in embryogenesis and negative effects of third generation antihistamine – desloratadine – after intranasal administration of 1.3 mg/m<sup>3</sup> and 13.0 mg/m<sup>3</sup> of the substance to laboratory animals during their prenatal period. In these circumstances, desloratadine does not cause any significant changes of embryogenesis<span lang="EN-US"> parameters</span>. Macroscopic examination of the fetus and placenta in animals of experimental groups did not reveal any pathology or physiological deviations from the norm. 13.0 mg/m<sup>3</sup> concentration of the drug caused a decrease in the weight of embryos in comparison with control group of animals and physiological data<span lang="EN-US">,</span> despite a well developed, without <span lang="EN-US">visible</span> pat<span lang="EN-US">h</span>ology, placenta. This neces<span lang="EN-US">­</span>sitates a<span lang="EN-US">n</span> in-depth study o<span lang="EN-US">f</span> possible teratogenic effects of intranasally administred desloratadine to laboratory animals.<strong></strong></p>Т. А. Alekhina, V. А. Turkina, О. І. Grushkahttp://journals.uran.ua/index.php/2307-0404/article/view/101437Tue, 04 Apr 2017 00:00:00 +0300Socio-economic status and antisocial behavior of children and teenagers.http://journals.uran.ua/index.php/2307-0404/article/view/101439
<p class="1">National Insti<span lang="EN-GB">­</span>tute for Health and Clinical Excellence (NICE) and <span lang="EN-US">a number</span> of conducted aim analyses, confirmed the presence of intercommunications between socio-economic status of children and teenagers and the<span lang="EN-US">ir </span>antisocial behavior and distinguished the role of such factors, as the<span lang="EN-US">ir</span> psychological features, age and sex. The clinical and psychological inspection of teenagers <span lang="EN-US">enabled to distinguish</span><span lang="EN-US">in </span>them such types of personality forming <span lang="EN-US">as</span>: aggressive, <span lang="EN-US">labial states, instable</span>, with "absence of brake", sexually-fixed, <span lang="EN-US">hysteroid</span>, apathetical, <span lang="EN-US">schizoid</span>, <span lang="EN-US">paranoidal</span>. <span lang="EN-US">P</span>rocesses of socialization, absence<span lang="EN-US"> or presence of </span>paternal attention to education<span lang="EN-US">,</span> capacity for co-operation between parents and teenagers, depression <span lang="EN-US">in</span> a mother or father, genetic and phenotype (external) factors cause antisocial behavior <span lang="EN-US">of</span> teenagers. It is shown<span lang="EN-US">,</span> that genetic factors that <span lang="EN-US">affect</span> antisocial behavior of teenagers were more expressive in rich families, while phenotype (external) <span lang="EN-US">–</span> in poor families. A review <span lang="EN-US">of </span>undertaken studies showed, that <span lang="EN-US">there is the</span> necessity of deep research of <span lang="EN-US">interaction</span> of social and biological factors for understanding of <span lang="EN-US">the </span>role of socio-economic factors in forming of antisocial behavior of children and teenagers.</p>S. A. Schudrohttp://journals.uran.ua/index.php/2307-0404/article/view/101439Tue, 04 Apr 2017 00:00:00 +0300Primary toxicological evaluation of nitroxoline on laboratory animals.http://journals.uran.ua/index.php/2307-0404/article/view/101440
Nitroxoline is an effective antibacterial agent that is industrially produced by chemical and pharmaceutical enterprises in Ukraine. Parameters of its toxicity are determined under conditions of acute and subchronic toxicological experiments on 3 kinds of laboratory animals, by administering the drug orally and by application onto the skin and mucous membranes. The duration of acute experiment was 14 days, subchronical - 24 days. It was found that median lethal dose (DL<sub>50</sub>) for white female rats is 980 (852:1127) mg/kg, of white male rats – 835 mg/kg, white male mice– 660 mg/kg, by this parameter the drug can be attributed to 3 class of hazard – moderately hazardous substance. Average effective time of death (ET<sub>50</sub>) for albino rats is 28 hours. Species sensitivity of laboratory animals to nitroxoline is slightly expressed. The death of the animals starts on the first day after the injection and is recorded during three days of the experiment. In application on intact skin, locally-irritant and skin-resorptive effects are absent. After contact with the mucous membrane of the eye the drug causes weak irritant effect. Nitroxoline has a moderate cumulative activity.G. I. Yaskivhttp://journals.uran.ua/index.php/2307-0404/article/view/101440Tue, 04 Apr 2017 00:00:00 +0300The influence of studies in Cognitive Wellness University for the elderly people on maintaining their cognitive functions.http://journals.uran.ua/index.php/2307-0404/article/view/101441
<p class="1"><span>Progressive aging of the population is accompanied by age-related changes in the body, primarily from the central nervous system, which causes a decline in the cognitive health of man and society as a whole. The emergence of cognitive deficits leads to a decrease in a person's ability to think, learn, actively perceive information, make decisions, worsen other psycho-physiological functions.</span><span>The </span><span lang="EN-US">aim</span><span> of our study </span>was<span> to assess the state of cognitive functions of the elderly people, the dynamics of their changes, depending on the age stage of life, as well as under the influence of program exercises and specially designed trainings aimed </span><span lang="EN-US">at</span><span> activating mental and physical activity. 165 students of the university aged 55-85 years took part in the study. Two groups of subjects were identified. The first </span><span lang="EN-US">one</span><span> number</span><span lang="EN-US">ing</span><span> 100 people we divided into 3 subgroups in order to identify phased age-related changes in cognitive functions and, depending on this definition, the need for preventive or corrective measures: 1 subgroup - 55-65 years, 2 subgroup - 66-75 years and 3 subgroup - 76 years and older. The study of their cognitive functions was determined upon admission to the university. The second group consisted of 65 people, whose indicators of cognitive functions were determined in dynamics: at admission to the university and at the completion of training. To assess the level of cognitive functions, we used a formalized screening technique - the Montreal Scale</span><span class="apple-converted-space"><span lang="EN-US">. </span></span><span>The established dynamics of the components of cognitive functions, depending on age, makes it possible to differentially approach the choice of preventive or corrective measures aimed at activating cognitive functions, in each age group with an emphasis on those of them that have been changed to a greater extent. The effectiveness of the proposed structure of studies at the university for the elderly was shown.</span></p>L. V. Usenko, G. S. Kanyuka, D. V. Oleniuk, O. O. Usenko, J. V. Silkinahttp://journals.uran.ua/index.php/2307-0404/article/view/101441Tue, 04 Apr 2017 00:00:00 +0300Memorable Dates. Minister-reformer of Public Health of Ukraine, scientisi, surgeon.http://journals.uran.ua/index.php/2307-0404/article/view/101442
<span>Memorable Dates. Minister-reformer of Public Health<br />of Ukraine, scientisi, surgeon.<br /></span>П. Фомін, Я. Березницький, Є. Шепетькоhttp://journals.uran.ua/index.php/2307-0404/article/view/101442Tue, 04 Apr 2017 00:00:00 +0300He lived for the sake of people. To the 180th anniversary of the Yekaterinoslav zemstvo doctor V.T. Skrylnikov (1837-1898).http://journals.uran.ua/index.php/2307-0404/article/view/101443
<p class="1"><span lang="EN-US">F</span>or the first time <span lang="EN-US">the a</span>rticle introduces <span lang="EN-US">to </span>the reader biography of one of the founders of the <span lang="EN-US">Ye</span>katerinoslav Medical Society, a local doctor, author of numerous scientific papers on medicine and hygiene Vasili<span lang="EN-US">y</span>Timofeevich Skrylnikov. The first part provides previously unknown details about <span lang="EN-US">his</span> origin, the work as the head of the free <span lang="EN-US">zemstvo</span> clinic, highlights his proposals in the field of sanitary service of the city <span lang="EN-US">Ye</span>katerinoslav, wide publishing activities. The aspects of V.T. Skrylnikov<span lang="EN-US">’s</span> service on guardianship of orphans, and the initiative to create <span lang="EN-US">Ye</span>katerinoslav <span lang="EN-US">Department of </span>Russian society of public health are <span lang="EN-US">touched upon</span>.</p>Yu. G. Pisarenkohttp://journals.uran.ua/index.php/2307-0404/article/view/101443Tue, 04 Apr 2017 00:00:00 +0300Importance of studying I.V. Leshko-Popel’s activities for the medical students’ moral education.http://journals.uran.ua/index.php/2307-0404/article/view/101445
<p class="1">This article is about I. V. Leshko-Popel who was a well-known doctor of Yeukaterinoslav in the late XIX century. He was called “the friend of the poor”, “People’s doctor”, “outstanding doctor-man”. He was always and everywhere ready to help selflessly the patient where poor people were waiting for him. Author of this article pro<span lang="EN-US">­</span>pose<span lang="EN-US">c</span> methods to study I. V. Leshko-Popel’s activities for moral education <span lang="EN-US">of </span>medical students.</p>L. S. Semenovahttp://journals.uran.ua/index.php/2307-0404/article/view/101445Tue, 04 Apr 2017 00:00:00 +0300The historical essay of the department of Pathological Physiology of Dnepropetrovsk Medical Academy.http://journals.uran.ua/index.php/2307-0404/article/view/101446
<p class="1">The article presents historical information about the deve<span lang="EN-US">­</span>lopment of the department of Pathological Physiology of Dnepropetrovsk medical academy, <span lang="EN-GB">about</span> chiefs <span lang="EN-US">of the depart­ment </span>and their contribution to the development of the department from its foundation (1918) <span lang="EN-US">up </span>to the present (2016). The areas of scientific research, the most significant achievements as well as changes in the <span lang="EN-US">provision</span> of educational process <span lang="EN-US">are</span> described.</p>Yu. V. Kozlova, M. A. Dovgal, V. V. Koldunov, Yu. V. Silkina, G. A. Klopotskiy, A. E. Khudyakov, S. I. Khmel, V. N. Bibikova, N. S. Tryasak, O. V. Anisimovahttp://journals.uran.ua/index.php/2307-0404/article/view/101446Tue, 04 Apr 2017 00:00:00 +0300Review of monograph of Doctor of Medicine, Professor Prokopov V.O. «Drinking water of Ukraine: medical-ecologic and sanitary-hygiene aspects» edited by Doctor of Medicine, Academician of NAMS of Ukraine A.M. Serdiuk. – K.: Academic Press «Medicine», 2016.http://journals.uran.ua/index.php/2307-0404/article/view/101447
<span>Review of monograph of Doctor of<br /><span>Medicine, Professor Prokopov V.O. «Drinking water of<br /><span>Ukraine: medical-ecologic and sanitary-hygiene aspects»<br /><span>edited by Doctor of Medicine, Academician of NAMS of<br /><span>Ukraine A.M. Serdiuk. – K.: Academic Press «Medicine»,<br /><span>2016. – 400 p.</span></span></span></span></span><br /></span>O. A. Shevchenkohttp://journals.uran.ua/index.php/2307-0404/article/view/101447Tue, 04 Apr 2017 00:00:00 +0300