Sympathetic control of bone mass regulated by osteopontin.

JUMP TO:

The sympathetic nervous system suppresses bone mass by incompletely understood mechanisms. These authors demonstrate that stimulation of sympathetic tone with isoproterenol increased osteopontin (OPN) and that mice lacking OPN had a decreased responses of bone to isoproterenol. They also show that intracellular OPN modulated the capacity of the β2-adrenergic receptor to generate cAMP with a corresponding modulation of cAMP-response element binding (CREB) phosphorylation and associated transcriptional events.