1Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, MD 21201, USA2Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA3Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD 21201, USA4Department of Molecular Pharmacology, Beckman Research Institute, City of Hope Medical Center, Duarte, CA 91010, USA5Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA