Introduction:The downstream effects of adipokine activity such as pathogenesis of inflammation which contribute to pain are well established but exact mechanisms are unclear. Previous studies have shown altered expression of pro-inflammatory adipokines in spinal cord from obese rats,1leading to the hypothesis that adipokines may play a role in pathogenesis of pain with obesity and diabetes.

Conclusion:RAGE is known to contribute to the development of diabetic vascular complications2and altered expression observed in this study matched to thermal hypersensitivity with diabetes suggests a role in pain modulation.