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This greek myth may have been one of the first demonstrations of the existence of stem cells in adults. According to the story, P was punished for giving fire back to the humans by being chained to a rock and having a bird eat his liver each day. P was able to survive this punishment because the bird left at dusk and P liver grew back duriing the night. This myth points out the ability of the liver to regenerate a process that depends on the presence of liver stem cells.

The existence and importance of stem cells was also demonstrated in WWII. A nuclear bomb was dropped on Hiroshima. It immediately caused widespread destruction and the deaths of 70K people. Many additional deaths followed in the next months and year as a result of radiation exposure. Many of the deaths resulted from the radiation killing stem cells in the body. Normally these stem cells divide and differentiate to replace lost cells. They are present in organs such as the liver, gut, skin, etc.

This slide shows the function of stem cells in the skin. Normally,……

This slide shows the function of stem cells in the skin. High radiation kills diff cells progenitors and stem cells…so skin cannot be repaired…

A third well known example of the existence and importance of stem cells was first demonstrated in the 1960s. It was shown that bone marrow could be transplanted to treat certain blood disorders. This depended on the presence of blood stem cells in the bone marrow.

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Course ObjectivesBy the end of this class you should be able to...Describe the sources, isolation, and characteristics of stem cells.Compare and contrast totipotent, pluripotent, multipotent, and unipotent stem cells.Compare and contrast embryonic and tissue-specific (adult) stem cells.Evaluate uses of stem cells for studying and treating human disease.Interpret, evaluate, discuss, and present papers from the primary literature.

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Giving a Presentation• Start slowly to give the audience time to settle down and focus on you• Speak up!• Talk to the audience not the screen• Convey your excitement about your proposal• Remember you are telling a story• Sometimes less is more Donovan

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Frame Your Talk• Tell people what you are going to tell them• Tell it to them• Tell them what you just told them Donovan

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Too much text can be distractingThe problem with putting too much text on the slide is that people feelobligated to try and read what you have written. Consequently, they tryand read and then don’t pay full attention to what you are actuallysaying. In other words it is distracting. Often that means that no-onemanages to actually finish reading what you have written before you areready to move on to the next slide. Then you move on to the next slideand they are left sitting there thinking “Oh, I must have missedsomething, maybe I should have listened instead of reading. But now itis too late. Oh my god what am I going to do!”But don’t worry there are solutions to this problem. Better to put bulletsof what you want to talk about and have the audience listen to you thanforce them to have to read several entire paragraphs of writing in a smallfont that they can hardly see from the back of the room.Anyway, those are my thoughts on the matter. I don’t know what do youthink? You’re sitting there at the back of the room squinting and trying toread all this crap. Do you have an opinion? Donovan

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Ancient Greeks The first stem cell biologists?According to Greek myth:To punish Prometheus for giving fire back to the humans, Zeus chained Prometheus to a boulder and had a giant bird eat his liver.At dusk each day, the bird flew away, Prometheus’ liver grew back, the bird returned the following day to feast again.

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The Dawn of the Nuclear AgeOn August 6, 1945, the nuclear By the end of the year,weapon, Little Boy, was dropped injury and radiation broughton Hiroshima directly killing an total casualties toestimated 70,000 people. 90,000-140,000 people.