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ACUTE EXPOSURE INFORMATION

Phosgene oxime is classified as a vesicant, an agent which causes a corrosive type of skin and tissue lesion. It is not a true vesicant since it does not cause blisters; therefore, it is best described as a uriticant or nettle agent. It is characterized by immediate pain and tissue damage within seconds. Extreme pain may last for several days. Damage to the eyes, skin, and airways is similar to that caused by mustard gas. The crystalline solid form will produce enough vapor to cause symptoms.

INHALATION - Severe respiratory irritant in low concentrations. Irritation begins at 0.2 mg/min/m(3) and becomes unbearable at 3 mg/min/m(3). Respiratory effects include pulmonary edema and death due to respiratory arrest.

SKIN - High concentrations cause severe skin irritation with rapidly developing necrotizing wounds. Immediate pain is followed by blanching with an erythematous ring in 30 seconds, a wheal in 30 minutes, and necrosis in 24 hours or later.