E:\ is not accessible

Good day
Hope you can assist, I am running win 2000 pro, My 2nd Harddrive has been ok but started acting up recently, It is not accessible this is the error I get, E:\ is not accessible, Incorrect Function. Any ideas what might be wrong.

Some HDDs have a removable circuit board
this board (in most cases ) is connected by fingers that are kind of spring loaded.
when the board is screwed down it makes contact with these fingers.
I have fixed a few of these by cleaning the contacts
always a good practice to have the manufacturers utility program it sometimes will help find problems