Rong Li, Ph.D.

The goal of our research is to understand how eukaryotic cells polarize, divide, move, and vary their genomes to adapt to the changing environment. We strive for integrated analyses on the systems level that combines whole-cell quantitative observation and mathematical modeling with cutting-edge molecular genetics approaches.

Rob Jensen, Ph.D.

Mitochondria play vital roles in the life and death of virtually all eukaryotic cells, mediating a diverse set of functions ranging from energy production to programmed cell death. Mitochondria are also incredibly dynamic, constantly moving, fusing and dividing. During cell growth, additional mitochondria are assembled from the import of proteins and lipids from the cytosol. In three very different systems we are investigating the molecular basis of these fascinating activities.

Katherine (Kathy) Wilson, Ph.D.

Within each human cell is a NUCLEUS, 'mothership' of the human genome and still the least-understood cellular structure. Chromosomes are enclosed by the nuclear envelope (NE) and communicate with the cytoplasm through Nuclear Pore Complexes (NPCs). The inner and outer membranes of the NE are mechanically connected by SUN-domain proteins and nesprins, which form LINC (links the nucleoskeleton and cytoskeleton) complexes. LINC complexes are anchored to nuclear intermediate filament (nuclear ‘lamina’) networks.