3 Answers
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There are a number of options for this that tweak basic hidden preferences and have several small UI tweaks built in. None of them have very substantial UI tweakery though.

Most of these have the same basic tweaks because they are simply enabling/disabling hidden preferences.

Cocktail - Has a number of hidden tweaks (including UI) in a simple application.Secrets - Has TONS of hidden preferences which include some UI tweaks.MacPilot - Has a number of hidden preferences with some UI.

If you are looking for something more similar to a styling application, there are a number of themed programs which will completely change the look.

If you don't know about it already, you should look at CandyBar which makes basic dock changes and icon styling dead simple. MacThemes has a number of excellent posts and threads on UI tweaks and themes that you might be interested in.

As a general all-round customisation tool, my vote goes to MacPilot, as menitioned by @bjtitus. The most common UI tweaks (displaying hidden files etc) are available, along with a load of other good stuff.

There is an article on MacWorld magazine here that has some other good info and recommendations that might help.

Of course, the CLI defaults command is where the real power lies, but it's pretty hardcore. Some good starter info here.