RESEARCH DESCRIPTION
The work in our laboratory is
focused on the hemostasis, ultrastructure, and normal signaling within the cerebral microvasculature, and their responses to
conditions of injury, including ischemia. These studies follow
from the consequences of focal ischemia in stroke patients.
Current work examines the interactions of the cellular and matrix
components of the neurovascular unit (including the endothelium,
astrocytes, and cells of the monocytoid lineage), and their
relationships to the integrity of the blood brain barrier. This group
has had a long-term interest in clinical recanalization methods in
thrombotic-thromboembolic stroke and their consequences to hemostasis,
to the neurovascular unit, and to the evolution of brain injury and
recovery.