The Telenovela actress, 41, criticized the GOP presidential nominee, 70, before welcoming New Jersey Senator Cory Booker to the stage. She first called out Trump for wanting to build a wall to keep immigrants out of the U.S. and for describing Mexicans as rapists and criminals.

Eva Longoria speaks at the Democratic National Convention in Philadelphia on Monday, July 25, 2016.Bill Clark/CQ Roll Call/Getty Images

"I'm from a small town in South Texas, and if you know your history, Texas used to be part of Mexico. I'm ninth-generation American. My family never crossed a border; the border crossed us," Longoria said. "When Donald Trump calls us criminals and rapists, he's insulting American families. My father is not a criminal or a rapist. In fact, he's a United States veteran."

Longoria also spoke about Trump's views on women. Back in 1994, the former Celebrity Apprentice host told NBC that "putting a wife to work is a very dangerous thing" and pregnancies are an "inconvenience" to businesses.

"When he said that a wife who works is a very dangerous thing, he not only insulted me, he insulted my mother who worked as a special-education teacher for 40 years and raised four children while being a wife," Longoria added.

The Desperate Housewives alumna received a round of applause for her remarks on Monday night. Most notably, she appeared to touch a nerve with the audience when she opened up about her eldest sister, Elizabeth Longoria.

"When Trump cruelly mocked a disabled reporter," she said, "he was also mocking my special-needs sister, Lisa, and many like her."

Viewers soon took to Twitter to support Longoria. "Eva Longoria gives a powerful and emotional speech about immigration, family, veterans, and special needs. #DemsInPhilly #ImWithHer," one commenter wrote. A second added: "@EvaLongoria thank you, thank you thank you!!! Preach it! My son is special needs, you just don't see it."

Longoria has been a proud Democrat for years. She previously spoke at the 2012 DNC in support of President Barack Obamaand his second term in the Oval Office.