1 R01 MH63420 (Nimgaonkar)5/1/03 – 3/31/08
NIMH Genetic Determinants of Bipolar Disorder This study aims to identify genes for bipolar disorder (BD) by testing single nucleotide polymorphisms (SNPs) across chromosomal regions previously linked to BD.
Role: Principal InvestigatorD43 TW 06167 (Nimgaonkar) 9/1/02 – 8/1/08 Training program for psychiatric genetics in India This grant will provide psychiatrists from India with genetics training at the University of Pittsburgh. Role: Principal Investigator 1 R21 MH079808-01 (Nimgaonkar)4/1/07 - 3/31/09Building Sustainable Research Capacity at Mansoura, Egypt To build research infrastructure in Mansoura, conduct a focused research project dealing with parents of patients with schizophrenia, and collect data that will enable a future R01 grant. Role: Principal Investigator 07R-1712 (Nimgaonkar)8/1/07 - 7/31/10Testing Biomarkers for Schizophrenia Based on Infectious Exposure & Host Genetic Variation To replicate and refine detected associations among individuals without schizophrenia, evaluate segregation of associated SNPs from detected associations among schizophrenia patients and their relatives. Role: Principal Investigator
(Nimgaonkar) Study of transcription patterns in blood cells from patients with Bipolar I Disorder The aim of this study is to better understand and characterize Bipolar 1 Disorder and related psychiatric diseases. We will compare changes in transcription patterns in hematological tissues obtained from a sample of cases with Bipolar 1 Disorder and a sample of unrelated controls. Role: Principal Investigator 58-3148-7-172 (Nimgaonkar)9/1/07 – 8/31/08
USDA Consanguinity and Bipolar Disorder in Egypt: Molecular Genetic Analyses This study will train junior clinical scientists and build research infrastructure at Mansoura University Hospital, Egypt, through extension of the PI’s funded work investigating consanguinity among parents of patients with Bipolar 1 Disorder and its relationship to the genetic etiology of schizophrenia. Role: Principal Investigator1 R01 MH066066-01A2 (Ganguli)5/1/04-4/30/09 A Clinical Trial of Weight Reduction in Schizophrenia This is a randomized trial of an intervention of weight reduction in schizophrenia and the effects of weight reduction on cardiovascular risk factors in this population. Role: Co-Investigator2 R01 MH60952-06 (Birmaher)7/1/06 - 6/30/11
NIMH Children of Bipolar Parents: A High Risk Follow-Up Study Aimed at investigating the early behavioral phenotypes, syndromal psychiatric disorders, circadian and sleep patterns, negative life events, psychosocial factors, and inherited traits that are associated with the development of BP in children. Role: Co-Investigator Stanley Medical Research Institute(Prasad) 3/1/06-2/28/09

A Randomized Double blind Controlled Trial of Valacyclovir Add-on Treatment of HSV Positive Early Course Schizophrenia Patients. A randomized, double blind, placebo controlled evaluation of the efficacy of Valacyclovir in treating symptoms of early course schizophrenia/schizoaffective disorder in patients positive for herpes simplex virus. Role: Co-Investigator 2 R10 MH56242 (Nimgaonkar)9/1/02 – 07/31/08*Genetic Susceptibility in Schizophrenia This study utilizes 3 independent family cohorts from the U.S., U.K., and India and a combination of affected sib-pairs analyses and family based association studies to localize genetic susceptibility for schizophrenia. Role: Principal Investigator 1 R01 MH66181 (Nimgaonkar)7/1/02 - 7/31/08* Schizophrenia Liability Genes among African-Americans. To identify genes that underlie liability to SCZ, a large and diverse sample of 1,260 African-American families all of whom have a least one member diagnosed with SCZ will be recruited at eight collaborating sites.Role: Principal Investigator Completed Research Support R03 TW06949-01 (Nimgaonkar) 11/1/04-10/31/07 Consanguinity and Risk of Bipolar Disorder I in Egypt This grant will examine rates of consanguinity among parents of a sample of patients diagnosed with Bipolar 1 Disorder. Comparison will be made to levels of consanguinity among parents of a matched sample without psychotic disorder. These studies may lay the foundation for future genetic studies among Egyptian patients. Role: Principal Investigator 5 R01 MH63480-05 (Nimgaonkar)7/24/01 - 6/30/07
NIMH A Neurobehavioral Family Study of Schizophrenia The goal of this proposal is to combine genetic and neurobiologic paradigms enabling detection and localization of genes that modulate susceptibility to schizophrenia and related phenotypes. Role: Principal Investigator 04R-771 (Nimgaonkar) 8/1/04-7/31/07
Stanley Medical Research Institute Schizophrenia Susceptibility: Joint Effect of Cytomegalovirus Exposure and Genetic Variation The objective of this project is to explore how cytomegalovirus exposure may contribute to risk for schizophrenia among individuals with defined alleles of the MICB and TNF genes. Role: Principal Investigator Contract No. N01MH80001 (Sachs)
Subcontract to University of Pittsburgh under NIMH Human Genetics Initiative Contract No. N01MH80001 to Massachusetts General Hospital A Bio-Materials Repository for STEP-BD participants This ancillary study to the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD) will support the collection of blood and other data from patients enrolled in the STEP-BD program. This effort ultimately enables a repository accessible to the scientific community. Role: Co-Investigator