Does or has anyone run the Trinket M0 with with Microsoft Data Streamer? CircuitPython is installed. YouTube has many videos for Arduino, but I can’t find one for CircuitPython and/or the Trinket M0. If yes, can you share some instructions or provide guidance.

It looks like Data Streamer comes as an Arduino sketch which would replace the copy of CircuitPython installed on your Trinket M0. Depending on what pins it expects, you should be able to run the Arduino sketch that they provide on the Trinket M0, though you may have to change the code to use different pins.