Her mentor and favorite teacher is Tweety. Sweetie's pink coloring, devious grin, and somewhat mean-spirited personality seem to be a throwback to Tweety's early appearances.

Sweetie's personality tended toward behaving in an amiable manner, but was prone to a mischievous streak when dealing with her main enemy and longtime pursuer, Furrball the cat.

Sweetie is voiced similarly to comedianJudy Tenuta---speaking in a liquid trill followed by a throaty screech (when excited).

In one short, Sweetie is seen to be owned by Elmyra Duff, who also owns Furrball, setting up the familiar scenario seen in earlier Sylvester and Tweety cartoons. Sweetie constantly outsmarts the predatory Furrball by making him look bad in front of his usually sweet-tempered owner, to the point of his eviction from the apartment.

In the episode "Go Sweetie Hyde", she accidentally transforms into a giant, grotesque bird-like monster and wants to chase and eat Furrball. In her monster form, she is voiced by Rob Paulsen and has a British accent.

In the episode segment from 'New Class Day', titled 'Just-Us League of Supertoons', Sweetie was a member of the mighty superhero team, the Just-Us League of Supertoons. She was Pink Canary, a parody of Black Canary.

Occasionally, Sweetie is shown to be running after Bookworm, in which case she is constantly outsmarted, or simply has bad luck.