Objective: To introduce a new animal model of graded mechanical primary brainstem injury (BSI). Methods: Altogether 45 rabbits were subjected to BSI by type II biological impact machine designed by the Third Military Medical University. The animals were divided into 4 experimental groups (n equal to 10) and 1 control ...

Despite the fact that astronauts living in the International Space Station (ISS) conduct daily two-hour intensive exercise programs to maintain their health, many health problems persist. These problems which include adverse effects of microgravity to bone, muscle and stamina, have not completely been countered. For example, bone mass reduction (about ...

The purpose of this study was to investigate the development of the osseous acetabular index (OAI) and cartilaginous acetabular index (CAI) using MRI. The OAI and CAI were measured on the coronal MR images of the hip in 81 children with developmental dysplasia of the hip (DDH), with a mean ...

Context-Kidney transplant is usually the best treatment option for patients with end-stage renal disease; however, transplant rates remain low in the United States. More research is needed about patients' educational needs to ensure that patients are making informed decisions about their treatment options.Objective-To examine patients' perceptions of the delivery and ...

The community health center (CHC), or neighborhood health center as it was originally known, was an innovation developed under President Lyndon Johnson's War on Poverty to address the needs of poor urban and rural Americans. The ranks of CHCs have grown from 8 pilot health centers in 1965 to more ...

Epizootic ulcerative syndrome was diagnosed, and the presence of Aphanomyces invadans confirmed, from an outbreak of clinical disease in wild-caught bony bream (Nematalosa erebi) from the Darling River near Bourke, in New South Wales, Australia, during 2008. This confirms a significant extension of the agent beyond its historical range.

In this exploratory and descriptive research, we identified the meaning of religion and spirituality in the experience of patients at a public health service for treatment of HIV/AIDS in a Brazilian upcountry town. Eight participants were selected through theoretical sampling. Data were collected through semistructured interviews, and analyzed by means ...

A female patient with primary sclerosing cholangitis developed a cholangiocarcinoma (Klatskin tumor) at the age of 42 years. It was successfully resected by hemihepatectomy and hepaticojejunostomy. In the next 15 years she had recurrent episodes of bacterial cholangitis and had to be hospitalized several times a year for intravenous antibiotitics. ...

CHARGE syndrome is a condition that has historically been diagnosed on the basis of the clinical findings of coloboma, heart disease, choanal atresia, restricted growth, and/or central nervous system anomalies, genital hypoplasia, and ear anomalies and/or deafness. Recently, researchers have discovered a genetic link, specifically, a strong association between the ...

Osteoporosis is one of the main diseases of the locomotive syndrome. Exercise therapy is a basic approach for prevention and treatment of osteoporosis, and is effective for increasing bone mineral density and preventing fall. Single foothold standing with the eyes open for one minute and squatting by "rokotore" are recommended ...

In this qualitative study, we provide an in-depth understanding of the views of healthy aging among Thai elderly and explore the ways that contribute to healthy aging. Data were collected using focus groups and in-depth interviews in four selected provinces of Thailand, and were analyzed using content analysis. The results ...

Autosomal recessive hereditary spastic paraplegias (AR-HSP) constitute a heterogeneous group of neurodegenerative diseases involving pyramidal tracts dysfunction. The genes responsible for many types of AR-HSPs remain unknown. We attempted to identify the gene responsible for AR-HSP with optic atrophy and neuropathy. The present study involved two patients in a consanguineous ...

In meat samples from 2 hunted red deer (Cervus elaphus) of different origins (region Ilanz, region Filisur) large-scale greenish tissue discolorations with a gelatinous change of fascia were observed and diagnosed as eosinophilic fasciitis. Sarcocystis hjorti, a recently described Sarcocystis species in red deer and moose in Norway, was found ...

Objective: To investigate the expression of Caspase-3 and Hsp70 in rabbits after severe traumatic brain injury (TBI) and to explore the feasibility of its application in estimation of injury time in forensic medicine. Methods: A rabbit model of heavy TBI was developed by high velocity impact on the parietal bone ...

Fragility fractures are the most serious complication of osteoporosis and have been recognized as a major public health problem. It is essential to precisely quantify the stress or strength of the fragile bone in order to estimate the fracture risk and plan preventive interventions. Quantitative computed tomography-based finite element method ...

Context-Little systematic research has been conducted to understand pain among persons with end-stage liver disease, especially among liver transplant candidates. Appropriate pain assessment and management are important areas of consideration as treatment options are limited.Objective-To describe the nature of chronic pain in patients with end-stage liver disease, the extent to ...

Osteocytes sense mechanical stress. Many long cell processes of osteocytes connect with osteoblasts and osteoclasts as well as other osteocytes. Tethering elements on the cell processes amplify mechanical strain. Primary cilia of osteocytes and integrin of extracellular matrix act as mechnosensors. Osteocytes express RANKL. The disruption of osteocyte-specific RANKL leads ...

A 48-year-old man sustained a traffic accident injury to his left leg. It was an open fracture of the left tibia and fibula accompanied by a large soft tissue defect (27 cm multiply 7 cm). Doppler examination revealed the posterior tibial artery was occluded due to thrombosis. Three weeks after ...

High-velocity penetrating pelvic injury is one of the most difficult challenges to trauma surgeons. The injury sites frequently include soft tissue, pelvis, genitourinary tract, vascular structures and intraabdominal viscera. We present an unusual case of a male patient suffering a collision at night with a deformed steel bar penetrating into ...

This study aims to examine the cardiovascular responses during an indoor race walking competition over the distance of 3-km for female and 5-km for male athletes. During the Italian indoor RW Championship heart rate was monitored on eleven well trained race walkers (five men and six women) and then refereed ...

The present study compared the ratings of perceived exertion (RPE) and immune-endocrine (IgA and cortisol) responses to simulated training matches (TM) and official matches (OM) in elite young male basketball players (N.=10). Saliva samples were collected from each player before and after three TM and two OM and subsequently tested ...

Simultaneous bilateral intertrochanteric fractures are very rare. There is a paucity of data in current literature documenting patients with such kind of hip fractures. It is severe and potentially life-threatening, associated with a high morbidity. The major determinants of successful outcome are high vigilance, early single stage stabilization and mobilization ...

The aim of the Clinical Practice Guideline (CPG) on the Management of Patients with Dyspepsia is to generate recommendations on the optimal approach to dyspepsia in the primary care and specialized outpatient setting. The main objective of this CPG is to help to optimize the diagnostic process, identifying patients with ...

The aim of the study was the evaluation of the autonomic cardiac function in professional soccer players by heart rate recovery (HRR) measurement after 1' or 2' of active recovery (HRR1 or HRR2, respectively) from an exercise stress test. Ninety-two adult professional soccer players (aged 25.27 ± 4.06 years). The ...

Insulinoma are rare tumours with an incidence of 4/100'000, supposedly hypoglycaemic symptoms, however, are often attributed to people without diabetes mellitus. The many different causes of hypoglycaemic disorders are best classified in whether occurring in healthy-appearing or ill patients. Patient's history and physical examination allow to substantiate the suspected hyperinsulinaemic ...

When compared to adults, pediatric fractures unite readily and nonunion is quite rare. Nonunion is often associated with open fractures, operative interventions, infection, pediatric osteogenesis imperfecta and neurofibromatosis. There are only a few studies and reports mentioning nonunion following conservative ma- nagement of closed pediatric fractures. We report here a ...

Pharmacogenetics is the study of genetic determinants of different responses to drug therapy and deals with differences in metabolic pathways and therapeutic effects as well as adverse reactions. A common genetic defect found in veterinary medicine is the MDR1 mutation occurring in Collies and related breeds that leads to an ...

Infants born prematurely lose the protection of the uterus at a time of fetal development when the brain is growing and organizing exponentially. Environmental factors such as stress in the neonatal intensive care unit (NICU) may play a role in altered brain maturation and neurobehavioral outcomes. Strategies aimed at reducing ...

In patients with heart failure and reduced left ventricular ejection fraction (HFrEF), renin-angiotensin-aldosterone system blockade reduces morbidity and mortality, but comes at an increased risk of adverse events (AEs). We utilized the HEAAL trial data to identify predictors of the most frequent investigator-reported AEs. The HEAAL trial investigated the relationship ...

We reviewed 212 consecutive patients with adolescent idiopathic scoliosis who underwent posterior spinal arthrodesis using all pedicle screw instrumentation in terms of clinical, radiological and Scoliosis Research Society (SRS)-22 outcomes. In Group 1 (51 patients), the correction was performed over two rods using bilateral segmental pedicle screws. In Group 2 (161 ...

Intra-operative, peri-articular injection of local anaesthesia is an increasingly popular way of controlling pain following total knee replacement. At the same time, the problems associated with allogenic blood transfusion have led to interest in alternative methods for managing blood loss after total knee replacement, including the use of auto-transfusion of ...

In this study, patients' experiences of a nurse-led rheumatology clinic for those undergoing biological therapy are discussed. The study had an explorative design, based on a qualitative content analysis with an inductive approach. Strategic sampling was used in order to achieve variations in experiences of a nurse-led clinic. Interviews were ...

Many urban areas struggle with significant health disparities. In Tulsa, Oklahoma, there is a 14-year difference in life expectancy between the predominantly African American population in north Tulsa and the predominantly Caucasian population in south Tulsa. The roots of Tulsa's health disparities can be linked, in part, to a long ...

Traumatic posterior hip dislocation is an uncommon injury in children, constituting less than 5% of paediatric dislocations. In a younger child (less than 5 years), minor trauma such as a slip or fall from a low height may cause a hip dislocation, whereas in an adolescent a dislocation is usually ...

Background-Although current national data show improved graft and patient survival following lung transplant, the effects of several modifiable preexisting comorbid conditions on health-related quality of life after transplant have not been evaluated. This study examines the effects of 3 comorbid conditions present before lung transplant (reduced bone density, diabetes mellitus, ...

Primary hyperaldosteronism is a clinical syndrome characterized by an elevated aldosterone secretion by the adrenals. The present case series describes 7 cats with primary hyperaldosteronism, which were presented between 2002 and 2011. Common clinical symptoms were weakness, anorexia, cervical ventroflexion and blindness. All cats showed hypokalemia. In 6 cats, blood ...

Through exploiting temporal, spectral, time-frequency representations, and spatial properties of mismatch negativity (MMN) simultaneously, this study extracts a multi-domain feature of MMN mainly using non-negative tensor factorization. In our experiment, the peak amplitude of MMN between children with reading disability and children with attention deficit was not significantly different, whereas ...

A priority system is one in which previously registered donors receive a preference in the allocation of organs for transplant ahead of those who have not registered. Supporters justify these systems on the basis that they are fair and will encourage donor registration. This article reviews existing studies of public ...

With an increased demand in the clinical field, physicians and nursing leaders in Iran have been working on developing an advanced practice nursing role. A neonatal nurse practitioner (NNP) program was developed by Tehran Medical University with cooperation of Iran's Neonatologist Association. The first group of master's students started their ...

Blood lactate concentration (BLC) has been the basis of rational performance diagnostics for almost five decades. Aim of this study was to identify the variability of the BLC during repeated constant power tests (VC-BLC) and to quantify the corresponding variability of changes in the BLC over time (VC-BLC-Difference). Twelve healthy ...

This study evaluated whether central command plays an important role in activating muscle sympathetic nerve activity (MSNA) during short-term maximal handgrip contractions. The increase in MSNA was examined while influence of minimizing for other factors such as mechanoreflex, metaboreflex and fatigue during repetitive exercise in seven 19- to 26-year-old participants. ...

Beginning in December 2012, all UK doctors will be required to complete a periodic revalidation process conducted by the General Medical Council (GMC) to retain their licence to practise medicine. Regular appraisals, based on the GMC's core guidance for doctors, will be used by responsible officers to evaluate a doctor's ...

Whole-body cooling, or therapeutic hypothermia, is increasingly becoming the standard of treatment for moderate to severe neonatal encephalopathy because it reduces neurodevelopmental disabilities and mortality in term neonates. Subcutaneous fat necrosis (SCFN) of the newborn has been identified as a potential side effect of birth asphyxia. In recent literature, there ...

Prior to human spaceflight the potential problems related to reduced gravitational forces on the musculoskeletal system were recognized, the extent and significance of the changes, however, were not known. Loss of bone mineral density has been a consistent finding after long-duration space flight and long-term bed rest. The main pathogenesis ...