PARAESTHESIA and Endocet

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PARAESTHESIA Symptoms and Causes

The brain, spinal cord, and nerves make up the nervous system. Together they control all the workings of the body. When something goes wrong with a part of your nervous system, you can have trouble moving, speaking, swallowing, breathing, or learning. You can also have problems with your memory, senses, or mood.

There are more than 600 neurologic diseases. Major types include

Diseases caused by faulty genes, such as Huntington's disease and muscular dystrophy

Problems with the way the nervous system develops, such as spina bifida

Degenerative diseases, where nerve cells are damaged or die, such as Parkinson's disease and Alzheimer's disease

PARAESTHESIA Clinical Trials and Studies

Treatments might be new drugs or new combinations of drugs, new surgical procedures or devices, or new ways to use existing treatments. The goal of clinical trials is to determine if a new test or treatment works and is safe. Clinical trials can also look at other aspects of care, such as improving the quality of life for people with chronic illnesses. People participate in clinical trials for a variety of reasons. Healthy volunteers say they participate to help others and to contribute to moving science forward. Participants with an illness or disease also participate to help others, but also to possibly receive the newest treatment and to have the additional care and attention from the clinical trial staff.

To compare the occurrence and severity of opioid-induced nausea and vomiting (OINV) associated with CL-108 to Norco.; To demonstrate the efficacy of CL-108 when compared to placebo for the relief of pain following surgical removal of impacted third molar teeth.; Reduction of the severity of nausea in patients treated with an opioid-containing pain reliever.; Reduction of vomiting in patients treated with an opioid-containing pain reliever.

Drug: Morphine PCA started at the end of surgery, 1 Percocet 1/325mg every 4 hours; may receive a second Percocet if needed.; Drug: For the 30ml ropivacaine the intervention would be the subject can request extra pain medication which would be Percocet and/or morphine PCA.

To estimate the prevalence and histologic spectrum of liver injury in an adult with Alpha-1 Antitrypsin deficiency and a genotype of ZZ.; To identify environmental and host risk factors for clinically significant liver fibrosis.; To define the diagnostic accuracy of non-invasive markers of fibrosis in AAT liver disease.; To explore epigenetic markers for the development of liver fibrosis.; To quantify liver fibrosis progression.

If you think you may have a medical emergency, call your doctor or 911 immediately.

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