Local: Spironolactone is a is a synthetic 17-lactone steroid belong to a class of drugs
called potassium-sparing diuretics which inhibit the exchange of sodium for
potassium and hydrogen ions in the distal tubule. It acts as a competitive
aldosterone antagonist in the distal renal tubules. Anti-androgen effect is also
utilized as a component of hormone replacement therapy for transgender, in the
treatment of hair loss, female hirsutism and acne but it can lead to adverse
effects. Spironolactone, as a potassium-sparing diuretic, increases the
secretion of water and sodium, while decreasing the excretion of potassium.
Aldosterone synthesis is stimulated by increased plasma angiotensin II or
potassium levels, which are present in proportion to plasma sodium deficiencies.
Spironolactone is mainly used in the treatment of refractory edema in patients
with congestive heart failure, nephrotic syndrome, or hypokalemia.
Spironolactone itself is a weak diuretic, and it is used in combination with
other diuretics. Angiotensin II antagonist such as valsartan, eprosartan and
telmisartan decrease the effects of aldosterone and used as antihypertensive.
Members of aldosterone antagonists include;

Harmful. May be harmful if swallowed. This substance has caused
adverse reproductive and fetal effects in animals. May cause eye
and skin irritation. May cause respiratory and digestive tract irritation.
This substance has caused reproductive effects in humans. This product
contains spironolactone, a substance known to the state of California
to cause cancer. Target Organs:Kidney, Male reproductive system.,
Female reproductive system., Bone marrow, Skin