Lelouch Lamperouge was the main protagonist of the story. He took disguise of Zero Requeim and made himself the enemy of the world only to get himself killed by his bestfriend. The saddest part after his death was everyone celebrated without knowing the truth.

4. Nina Tucker – Fullmetal Alchemist

image source – Monsters & Creatures Wiki

Nina Tucker was the daughter of Shou Tucker. Shou Tucker was a state Alchemist. Shou conducts a chimera experiment with her dog Alexander to keep his state alchemist license. Scar kills Shou and also kills Nina to free her from her suffering in chimera form.

3. Portgas D. Ace – One Piece

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Portgas D. Ace was the son of the pirate king Gol D. Roger. When Luffy and his friends went to Marinefold to save him. Both were attacked by Akainu however when Akainu tried to attack Luffy Ace came to save him but Ace got in between them and took a magma feast through his body to save Luffy.

2. L – Death Note

image source – Death Note Wiki

L was the world’s best detective. But before his death he knew he was going to be killed by Light Yagami. But the saddes part was that L taught light was his only friend but Light killed him.

1. Maes Hughes – Fullmetal Alchemist

image source – Adagio Teas

Maes Hughes was a character in the anime Fullmetal Alchemist. He was a caring father. He was killed by Envy disguised as his own wife. His death is considered as one of saddest anime deaths.