Hypomania soon after shifting from paroxetine to agomelatine in a middle-aged woman with depression.

Hypomania soon after shifting from paroxetine to agomelatine in a middle-aged woman with depression.

Clin Neuropharmacol. 2014 May-Jun;37(3):82-3

Authors: Tu KY, Lin PY

Abstract
Hypomania or mania has been reported to be induced by multiple classes of antidepressant agents. Agomelatine is a newly approved drug for treating major depression, and its antidepressant effect works through distinct pharmacodynamic mechanisms from most other commonly used antidepressants. Here, we report a middle-aged female patient who presented hypomanic symptoms shortly after shifting from paroxetine to agomelatine.