this study failed to replicate a GWAS reporting an association between the 2 SNPs rs2296308 in RWDD3 and rs1829 in the intron of TECTA (显示 TECTA 抗体) and time to neuropathy in ovarian cancer patients treated with paclitaxel

a degree of redundancy of the RSUME variants on the SUMO pathway

RSUME interacts with glucocorticoid receptor and increases its SUMOylation and transcriptional activity, pointing to SUMO conjugation as the cause for transcriptional stimulation.

RSUME critically regulates HIF-1a (显示 HIF1A 抗体) and VEGF-A (显示 VEGFA 抗体) production and thus might play an important role in pituitary tumour neovascularisation

RSUME plays a central role in the regulation of sumoylation and, hence, several critical regulatory pathways in mammalian cells [RSUME].