MicroRNAs (miRNAs) are a group of small, noncoding RNAs that modulate the translation of genes into proteins by binding to specific target sites in messenger RNAs. This study investigated the biological function and molecular mechanism of...

MiR-17-92 is an oncogenic miRNA cluster implicated in the development of several human cancers; however, it remains unknown whether miR-17-92 cluster is able to regulate hepatobiliary carcinogenesis. This study was designed to investigate the...

Ethylene dichloride (EDC) is a chemical of substantial economic importance and environmental concern. It has produced injury in both man and animal following its acute administration. Mutagenic and carcinogenic potentials have also been...

This thesis deals with the potential role of the carbohydrate of human fibrinogen in its hepatic catabolism. First, the primary structure of carbohydrate in human fibrinogen was studied. The structural information was used to investigate the...

Glucan, a beta-1,3-linked polyglucopyranose isolated from yeast cell walls, is a potent tumor inhibitory and macrophage activating agent. Evidence suggests that macrophages play an important role in glucan-enhanced antitumor activity. The present...