The article's lead author, Prof. Robbert J. de Winter, worked in conjunction with the European Cardiovascular Research Institute (ECRI) along with Professors Patrick Serruys and William Wijns. Professors Serruys, de Winter, and Wijns together comprised the steering committee that oversaw the DESSOLVE III study design and conduct.

DESSOLVE III is a prospective, balanced, randomized, controlled, single-blind, multi-center all-comers study comprising ~1,400 patients. The primary non-inferiority endpoint of the trial was target lesion failure (TLF) at 12 months. MiStent met the endpoint, showing numerically lower TLF (p=0.0001 for non-inferiority) and target lesion revascularization (TLR) rates. TLR rates for MiStent were numerically lower at all time points following the procedure, and at one year the difference increased to 1.2%. In addition, MiStent maintained numerically lower rates of definite or probable stent thrombosis (ST) at 12 months.

Patients in this trial suffered from symptomatic coronary artery disease, including those with chronic stable angina, silent ischemia, or acute coronary syndrome (including non-ST-elevation myocardial infarction and ST-elevation myocardial infarction), and qualified for percutaneous coronary interventions. The primary endpoint for this trial was a non-inferiority comparison of TLF for the MiStent group versus the Xience group at 12 months post-procedure.

Dennis Donohoe, M.D., chief medical advisor to Micell, added, "It is an honor to have the DESSOLVE III data published by a prestigious peer-reviewed medical journal such as The Lancet. This adds to the growing body of evidence in support of the clinical and health economic benefits of Micell's supercritical fluid technology."

About MiStent®

MiStent is designed to optimize clinical performance and healing in patients with coronary artery disease. The rapidly absorbable coating of MiStent, which contains crystalline drug (sirolimus) and an absorbable polymer, is intended to precisely and consistently provide for extended local drug delivery and limit the duration of polymer exposure. These characteristics potentially reduce the safety risks associated with currently commercially available drug-eluting stents and improve long-term clinical outcomes.

MiStent has received CE marking, but is not approved for sale in the United States.

About The Lancet

The Lancet is committed to applying scientific knowledge to improve health and advance human progress. It is currently ranked second out of 151 journals in the Medicine, General & Internal subject category (2016 Journal Citation Reports®, Clarivate Analytics 2017). For more information see www.thelancet.com.

Caution Regarding Forward-Looking Statements

This press release contains forward-looking statements that can be identified by the fact that they do not relate strictly to historical or current facts. Forward-looking statements include words such as "anticipates," "estimates," "expects," "projects," "intends," "plans," "believes" and words and terms of similar substance in connection with the results of a post-marketing clinical program and the commercialization and sale of MiStent in Europe and other markets. We caution readers that the forward-looking statements contained in this press release are predictions based on our current analysis of, and expectations about, future events and speak only as of the date of this press release. These forward-looking statements are not guarantees of future performance and are subject to risks and uncertainties, including, but not limited to, the following: the results of any further clinical trials and studies; our ability to obtain regulatory approval of the MiStent in other jurisdictions; the successful development and commercialization of MiStent in Europe and other markets; the ability of MiStent to effectively and successfully compete with current commercially available drug-eluting stent technologies in Europe and other markets; and our ability to maintain and protect our proprietary stent coating technology. Actual results, performance or achievements could differ materially and adversely from those expressed or implied by any forward-looking statement contained in this press release.

Micell, Micell Technologies, the Micell Logo, and MiStent are among the trademarks of Micell Technologies, Inc.