A condition characterized by
slight to moderate short stature, hypertelorism,
small nose with anteverted nares, broad philtrum, orthodontic problems, brachydactyly,
prominent umbilicus, and shawl scrotum. A spectrum of behavioral disorders may be part
of the AAS phenotype. May be at increased risk for mental deficiency.
The condition is transmitted by mutations
in a gene called FGDY1 in band p11.21 on the X chromosome and follows
an X-linked recessive inheritance (sex-linked)
pattern.

The body cavity
below the chest that contains the stomach, liver, intestines and other organs.

Abdominal circumference (AC)

The distance around fetal abdomen.

The abdominal circumference is measured by sonogram from outer skin surface
to outer skin surface

The appropriate transverse plane for measurement of the fetal abdominal circumference (AC) should include the umbilical vein at the level where the umbilical vein enters the liver. The ossification centers of the spine should be aligned.

UV =Umbilical
vein S= Spine

Abortion

Termination of pregnancy
before the fetus is developed enough to survive.

Related terms:

Incomplete Abortion: Passage of some but not
all fetal or placental tissue from the uterus before 20 weeks'

Threatened Abortion: Uterine bleeding at
less than 20 weeks' without opening or other change in the cervix

Abruptio placenta (Placental abruption)

Partial or complete separation of the placenta from the uterus before delivery. It
happens in 0.8-1.0% of all pregnancies and has a high recurrence
rate. Contractions are usually present. Bleeding is also present in
approximately 80% of patients.
Factors that have been associated with abruption include maternal hypertension, intrauterine growth restriction (IUGR), non-vertex presentation, polyhydramnios, advanced maternal age, maternal smoking, cocaine use, chorioamnionitis,
premature rupture of membranes, and blunt external maternal trauma

āc

Before meals

Acceleration

An acceleration is an abrupt increase in the fetal heart rate above baseline with onset to peak of
the acceleration less than 30 seconds and less than 2 minutes in duration.

Adequate accelerations are
defined as:

In a fetus less than

32 weeks' gestation an
increase in heart rate greater than or equal to 10 beats per minute
above baseline for greater than or equal to 10 seconds.

In a fetus greater than 32 weeks' gestation an increase
in heart rate greater than or equal to 15 beats per minute above
baseline for greater than or equal to 15 seconds.

Acromelia

Shortening of the hands or feet

Active Labor

The active phase (active labor) of labor begins when the cervix is opened
(dilated) to 6 cm in the presence of uterine contractions. During the
active phase uterine contractions become more frequent, the cervix dilates more
quickly, and the baby descends into the pelvis.

Acute Cervical Insufficiency

Cervical dilation of at least 2 cm with membranes visible at 16 0/7 to 22 6/7
weeks' gestation as used by Owen J et al.

Collective term for the placenta and fetal
membranes that are delivered after the infant

Agenesis of the corpus callosum (ACC)

A birth defect in which there is partial or complete absence of the corpus
callosum (the bundle of nerve fibers that connects the two hemispheres of the
brain).

ACC may occur as an isolated defect, but it is frequently associated with
other malformations, chromosomal abnormalities (trisomy 18 an trisomy 8), and genetic syndromes.
The outcome of the abnormality depends on the underlying cause and the
presence of other structural defects. Isolated ACC (in particular partial ACC) is associated with no or
mild neurologic impairment in a large proportion of cases. ACC occurring as part
of a syndrome may be associated with severe mental retardation and seizures. ACC does not cause
death in the majority of children.

Ultrasound findings include absence of the corpus callosum
and cavum septum pellucidum, 'teardrop' configuration of the lateral ventricles,
dilatation and upward displacement of the third ventricle (interhemispheric
"cyst") , and abnormal branching of the anterior cerebral artery.
Magnetic resonance imaging is sometimes useful in confirming the diagnosis.

The risk of recurrence
is ~ 1% for sporadic cases, 25% if ACC is associated with an autosomal
recessive cause, and 50% of males will be affected if inherited as an X-linked recessive disorder.

Akinesia

Absence or lack of movement

Alloimmunization (Isoimmunization)

Production of an antibody against antigens produced by members of the same species.

Alpha-fetoprotein (AFP)

A protein produced by the fetal liver and yolk sac that can be detected in
the mother's blood. Alpha-fetoprotein levels rise gradually throughout most of
pregnancy and level off near term. High levels of alpha-fetoprotein are
associated with a more advanced pregnancy than expected, multiple pregnancy,
fetal death (including a vanished twin), an opening in the spine (spina bifida),
an opening in the head (anencephaly), or an opening in the abdominal wall
(gastroschisis). Low levels may be associated with Down syndrome, trisomy
18, and some cases of Turner syndrome.

Amniocentesis

A procedure in which a needle is inserted into the uterus and a sample of the
fluid surrounding the fetus is drawn out. The procedure may be done to evaluate
the fetal chromosomes, to determine fetal lung
maturity, or to obtain fluid to culture for possible infections. The procedure
may also be performed to remove an excessive amount of amniotic fluid.

The sonographic finding of dense aggregates of particulate matter in the
amniotic fluid close to the internal cervical os. Amniotic Fluid (AF) ‘sludge’
has been associated with microbial invasion of the amniotic cavity (MIAC), and
histologic chorioamnionitis in patients with spontaneous preterm labor and
intact membranes

The membrane (amnion) that surrounds the fetus and the amniotic
fluid.

Amniotic sheet

A 'shelf' in the amniotic cavity seen during ultrasound examination. Amniotic sheets
represent chorion and amnion that has grown around uterine synechiae (
adhesions) . Incomplete amniotic sheets have a free edge. Complete
amniotic sheets have no free edge, and have been associated with increased risk
for intrauterine death.
Amniotic sheets may be mistaken for amniotic bands. However, amniotic bands more
often appear as multiple thin membranes, and are frequently attached to
the fetus. Circumvallate placenta is another cause of uterine band, sheet, or shelf.

A procedure performed (often using a plastic device that looks like a crochet
needle ) to open the amniotic sac usually for the purpose of inducing or
speeding up the progress of labor .

Anemia

Decreased amount of normal hemoglobin in blood. Hemoglobin is
the substance in red blood cells that carries oxygen.

Anencephaly

A birth defect resulting in the absence of a major portion of the skull and
brain. Anencephaly results when the upper portion of the neural tube fails to
close. The condition is not compatible with life, and infants usually die within
a few days after delivery. See picture

Anesthesia

Loss of sensation.

Angle of insonation

A

measure of deviation from
"straight on" to a reference plane measured in degrees. For example a Doppler
ultrasound beam aligned to the flow of blood in a vessel has a zero degree of
insonation to the flow. A Doppler
ultrasound beam aligned perpendicular to the flow of blood in the same vessel
has a 90 degree angle of insonation to the flow.

Angelman syndrome ("Happy Puppet Syndrome")

A disorder characterized by a large jaw and open-mouthed expression revealing
the tongue, severe speech impairment, motor and intellectual retardation,
ataxia, poor muscle tone, seizures, frequent laughing, smiling, and
excitability. The disorder is usually caused by abnormalities of chromosome 15.

A deletion of chromosome in the 15q11-q13 region accounts for up to 75% of
cases and has a less than 1% recurrence risk. Mutations in the UBE3A gene on
chromosome 15 accounts for 6 to 20% of cases and has a recurrence risk of less
than 1% unless the patient's mother carries the UBE3A mutation on her own
paternally inherited chromosome 15. In the latter case there is a 50% recurrence
risk. Angelman syndrome is less commonly caused by inheritance of two copies of
chromosome 15 from the father and no maternal copy of chromosome 15 (uniparental
disomy) , or mutations in the imprinting center of the UBE3A gene.

Aniridia

Absent or partially absent iris accompanied by macular and optic nerve
hypoplasia. Symptoms include poor vision sensitivity to light (photophobia),
and nystagmus. Frequently associated abnormalities include glaucoma
and cataracts. Mutation of the PAX 6 gene or deletion of a regulatory region controlling its expression, appears to be responsible for
aniridia occurring as an isolated ocular defect . The condition is
autosomal dominant.

Aniridia may also occur as part of the Wilms tumor-aniridia-genital anomalies-retardation (WAGR) syndrome, with a deletion of 11p13 involving the PAX6 (aniridia) locus and the adjacent WT1 (Wilms
tumor) locus.

Anomaly

Malformation or abnormality.

Antenatal

Before birth.

Antenatal steroids

Steroids (either betamethasone or dexamethasone) given to help the fetal lungs and other organs mature more rapidly.
Antenatal steroids are given when preterm delivery is anticipated between 24 and 34 weeks' gestation with intact membranes, and
at 24 to 32 weeks' with ruptured membranes.

Antepartum

Before delivery or birth.

Anterior

In front

Antibody (Immunoglobulin)

Proteins secreted by white blood cells (lymphocytes) that
bind to foreign molecules. Antibodies attach to the antigens and destroy the
invader directly , or label them for removal by your white blood cells.Antibodies (immunoglobulins) are grouped into five classes or isotypes: IgG,
IgA, IgM, IgD, and IgE.

A molecules that stimulates antibody production is called an antigen (antibody generator).

Anticardiolipin antibodies (ACA, aCL Antibody)

An antibody that attaches to cardiolipin , a fatty molecule, found
mostly in the mitochondrial inner membrane where it is synthesized from
phosphatidylglycerol . ACA may be found in several diseases including
antiphospholipid syndrome and systemic lupus erythematosus (SLE). Three classes
of cardiolipin antibodies may be present in the blood: IgG, IgM and/or IgA.

Anti-c antibody (little c antibody)

A protein made by the immune system that binds to a molecule called the c antigen found on the surface of red blood cells. The c antigen is part of the
Rhesus blood group system which consists of several antigens (D
, E
, e
, c,
C,
). The antibody hastens removal of the c antigen (and the foreign blood cells) from the body.

Anti-c antibody is capable of crossing the placenta and causing anemia in the fetus and
hemolytic disease of
the newborn. Pregnancies complicated by anti-c antibody are managed as for Rh-D sensitization .

Anti-D antibody (Rh sensitization, Rh disease)

A protein made by the immune system that binds to a molecule
called the D antigen found on the surface of red blood cells. The D antigen is
part of the Rhesus blood group system which consists of several antigens (D
, E
, e
, c,
C,
).

The antibody hastens removal of the D antigen (and the
foreign blood cells) from the body.

A protein made by the immune system that binds to a molecule called the Fya
antigen found on the surface of red blood cells. The Fya antigen is part of the Duffy blood group system
which consists of the antigens Fya and
Fyb . The antibody hastens removal of the and Fya antigen (and the foreign blood cells) from the body.

Anti-Fya antibody is capable of crossing the placenta and causing SEVERE anemia in the fetus and
hemolytic disease of
the newborn. Anti-Fyb has not been reported to cause significant hemolytic disease of
the newborn.

Anti-Kell antibody

A protein made by the immune system that binds to a molecule called the Kell antigen found on red blood cells. The Kell
antigen is part of the Kell blood group system which consists of several antigens ( Kell
or K1 , Kpa,
k
, Jsa
,Jsb ). The antibody hastens removal of the Kell antigen (and the foreign blood cells) from the body.

A protein made by the immune system that binds to molecules called the Lewis
antigens,
Le
a and Le b. Lewis antigens are not made by the red blood
cell, but are antigens present in body fluids and secretions that have been
adsorbed onto the surface of the red blood cell.
Lewis antigens are found in very low levels on the fetal red cells.

A protein made by the immune system that bind to a molecule called the S antigen found on the surface of red blood cells.
The S antigen is part of the MNS blood group system which consists of several antigens (
M,
S,s,
N)

Midline
thickening of the wall of the uterus at the uterine fundus (top of the
uterus). The thickened area results from failure to completely dissolve the
uterine septum during development. The arcuate uterus is considered to be a mild form of
bicornuate uterus.
An arcuate uterus does not appear to have an unfavorable effect on
pregnancy.

Areola

The darker colored area around the nipple of the breast

Arnold-Chiari Malformation

A group of birth defects of the cerebellum (the part of the brain that
controls balance) and base of the skull characterized by downward displacement of the cerebellum and
related structures below the level of the foramen magnum (the large hole at the
base of the skull).

The three types of Arnold-Chiari malformation are:

Type I:
The fourth ventricle (the fluid filled cavity between the cerebellum and pons of the
brainstem) remains in its normal position.
The lower most structures of the cerebellum (the cerebellar tonsils)
are displaced through the foramen magnum.

Many persons with a Type I malformation have no symptoms. However,
some persons may experience headache that is aggravated by
coughing and straining, weakness or loss of sensation of the upper arms
and hands, slurred speech,
trouble swallowing, dizziness, or trouble balancing.

Type II:

The
fourth ventricle is at the level of the foramen magnum. The cerebellar tonsils, parts of the cerebellum, pons, and medulla oblongata are displaced through the foramen magnum.
Typically accompanied by hydrocephalus
and myelomeningocele (open spina bifida).

Type III: Displacement of the fourth ventricle in addition to the the cerebellum, pons, and medulla oblongata through the foramen magnum.
Usually ccompanied by encephalocele or myelomeningocele .

Arrest of descent

Second-stage arrest may be diagnosed if there has been
"No progress (descent or rotation) for
4 hours or more in nulliparous women with an epidural
3 hours or more in nulliparous women without an epidural
3 hours or more in multiparous women with epidural
2 hours or more in multiparous women without an epidural"

For spontaneous labor:
6 cm or greater dilation with membrane rupture AND
4 hours or more of adequate contractions (e.g., > 200 Montevideo units) OR
6 hours or more if contractions inadequate with no cervical change

For induced labor:
6 cm or greater dilation with membrane rupture or 5 cm or greater without
membrane rupture AND
4 hours or more of adequate contractions (e.g., > 200 Montevideo units) OR
6 hours or more if contractions inadequate with no cervical change [4].

Stimulation the uterus to increase the frequency, duration , or strength of
contractions when spontaneous contractions have failed to cause dilation or thinning (effacement) of the cervix leading to the delivery of the infant.

"Infusion of blood or blood component to the same individual from whom it
was taken"

Autosomal dominant

A trait determined by a gene on any chromosome other than a sex chromosome
(X or Y) that requires only one gene for the trait to be expressed. The chance
of passing the trait to an offspring is at least 50% for each pregnancy.
See Diagram

Autosomal recessive

A trait determined by a gene on any chromosome other than a sex chromosome
(X or Y) that requires two genes for the trait to be expressed. A person with
only one copy of the gene is said to be a carrier for the trait.
See Diagram