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HighVolumeHDF as standard

With the new AutoSubplus function of the 5008 and the 5008S HighVolumeHDF becomes as simple and reliable as HD without any additional need for user interaction.

5008S CorDiax

Opening a world of possibilities

5008S CorDiax enables HighVolumeHDF as a standard in dialysis thanks to AutoSubplus for automatically maximized substitution volumes and the Venous Access Monitor (VAM) for increased probability of early detection of needle dislodgement.

5008 CorDiax

Beyond your expectations

Next to AutoSubplus and VAM the 5008 CorDiax also offers patients with challenging conditions the possibility for a high convective therapy – MIXED HDF.

HighVolumeHDF therapy

HighVolumeHDF — The standard in cardioprotective hemodialysis

In order to achieve the full benefits of HDF therapy large convective volumes in post-dilution mode are required. In the past many users were concerned that these high volumes may lead to excessive hemoconcentration and subsequently high transmembrane pressures if the treatment settings are not continuously monitored and adjusted.

The innovative AutoSubplus system is much more than just another automatic pressure control:

Very precise information on the conditions in the dialyzer is available - not just across the membrane but also along the blood flow pathway

Several checks per minute enable the continuous optimization of the substitution rates

The system is automatically activated at the start of treatment

AutoSubplus supports the nephrologist in establishing HighVolumeHDF as standard therapy.

A close up of two substitution pumps that make Mixed HDF possible.

Insight and continuity make the difference

While other systems check and adjust the transmembrane pressure (TMP) in defined time intervals, AutoSubplus measures and evaluates the conditions directly inside the filter several times per minute. The innovative technology behind it is based on a dynamic signal analysis of pressure pulses. As a result, substitution volumes can be maximized individually for every patient without any user interaction.

MIXED HDF – HDF without exceptions

Although most patients will reach sufficient substitution volumes with AutoSubplus, there might be patients with unfavorable conditions unable to reach sufficiently high convective volumes. For these patients we have intensified our research and developed the MIXED HDF option for the 5008 CorDiax.

The 5008 CorDiax enables the simultaneous delivery of post- and pre-dilution volumes — the so called MIXED HDF. With its two substitution pumps, the convective transport can be increased by adding a pre-dilution share to avoid the risk of hemoconcentration or to compensate for low blood flows.

Safety creates confidence

In particular during HighVolumeHDF where high blood flows are aspired for, monitoring of the venous access is essential as a blood loss would become critical within a very short time. The 5008 CorDiax and 5008S CorDiax offer as standard in all machines a sophisticated safety feature to minimize the risk of external blood loss:

VAM is a unique and intelligent safety feature. It enables dynamic and highly-sensitive monitoring of the venous pressure by combining arterial and venous pressure signals with an adaptive algorithm. In this way, VAM is designed to indicate sudden, small drops in venous pressure of approximately 15 mmHg, even when the venous pressure does not exceed the lower alarm limit. VAM has been developed to support the health-care professionals in early detection of venous needle dislodgement. Still, the user remains responsible for patient safety at all times during treatment. VAM also includes an alarm management system: an alarm is activated if the monitored signals show exceptional or abnormal variations to the previous pressure profile.

If an alarm is emitted, the blood pump is stopped immediately and the venous clamp is closed. This aims to give the nursing staff more time to react appropriately to critical pressure changes.

Easy handling

ONLINEplus – Reducing workload, increasing usage

Historically, the required amounts of substitution fluid had to be provided in infusion bags. This added to the workload of the nursing staff and deterred dialysis-centers from using HDF. In order to give more patients access to the benefits of HDF, we have developed a dialysis system, which prepares the substitution fluid directly at the bedside – The ONLINEplus system. Based on the highly reliable two stage filtration process ONLINEplus facilitates the online production of sterile and nonpyrogenic substitution fluid very cost-efficiently. Online hemodiafiltration was born.

Blood lines

Our innovative blood lines are developed based on the idea that HighVolumeHDF shall be as easy and safe to handle as HD. With a standard setup of a 5008 CorDiax or 5008S CorDiax you can already perform HighVolumeHDF.

Efficient and sustainable

Our innovative blood lines are developed based on the idea that HighVolumeHDF shall be as easy and safe to handle as HD. With a standard setup of a 5008 CorDiax or 5008S CorDiax you can already perform HighVolumeHDF.

It is not only the advanced treatment options that makes the 5008 series unique, but also its eco-friendliness: with the 5008 CorDiax series, Fresenius Medical Care supports the sensible and sustainable use of resources by saving dialysate, water and energy. This in turn leads to significant cost savings.

ONLINEplus technology for production of sterile, endotoxin-free and bicarbonate-buffered electrolyte solutions1

Extensive amounts of substitution fluid for HDF available

No more need for ready-made rinse solutions: priming, reinfusion and bolus with ONLINE fluid in all treatment modes (also in HD)2