we show that the non-catalytic region of tyrosine kinase adaptor (NCK) proteins 1 and 2 are distributed in the developing spinal cord

Nck proteins not only participate in thymic selection and generation of the peripheral T cell repertoire but also are involved in the differentiation and effector functions of CD4 (show CD4 Proteins)(+) T cells.

these data identify Nck as an important mediator of oxidative stress-induced (show SQSTM1 Proteins) inflammation and a potential therapeutic target for ischemia/reperfusion injury.

Nck may function as an effector of T-cell receptor conformational changes during T cell development.

Mouse embryos lacking endothelial Nck1/2 expression develop extensive angiogenic defects that result in lethality at about embryonic day 10.

that Nck recruitment to the TCR is fundamental to mount an efficient T cell response in vivo, and that the Nck-CD3epsilon (show CD3E Proteins) interaction may represent a target for pharmacological modulation of the immune response.

Cytoplasmic Protein NCK1 (NCK1) Protein Profile

Protein Summary

The protein encoded by this gene is one of the signaling and transforming proteins containing Src homology 2 and 3 (SH2 and SH3) domains. It is located in the cytoplasm and is an adaptor protein involved in transducing signals from receptor tyrosine kinases to downstream signal recipients such as RAS. Alternatively spliced transcript variants encoding different isoforms have been found.