Authorities have lead the man from an Epping house in handcuffs.

Victoria Police have arrested a man who was armed with a handgun and refused to exit a house in Melbourne's North on Friday.

Authorities were negotiating with the 26-year-old man, who is believed to have exited a house on Wedge Street, Epping before returning inside. The police operation came as part of an ongoing investigation by the Darebin Crime Investigation Unit, according to a statement.