Was detached to Twelfth Air Force in Algeria in May 1943 to provide air resupply and transport during the North African Campaign in Algeria and Tunisia. Also performed combat casualty evacuation of wounded personnel to rear areas. Remained under jurisdiction of VIII ASC while in North Africa, providing transport between England and North Africa from its base in Algeria. Returned to England in early 1944 to participate in the buildup of forces prior to the Allied landings in France during D–Day in June 1944.

After the Normandy invasion the squadron ferried supplies in the United Kingdom. The squadron also hauled food, clothing, medicine, gasoline, ordnance equipment, and other supplies to the front lines and evacuated patients to rear zone hospitals. It dropped paratroops near Nijmegen and towed gliders carrying reinforcements during the airborne attack on the Netherlands. In December, it participated in the Battle of the Bulge by releasing gliders with supplies for the 101st Airborne Division near Bastogne.

Moved to Belgium in early 1945, and participated in the Western Allied invasion of Germany, participating in the air assault across the Rhine River in March 1945, each aircraft towed two gliders with troops of the 17th Airborne Division and released them near Wesel.

In late May 1945, after V-E Day, the squadron was moved to Waller Field, Trinidad and attached to Air Transport Command. From Trinidad, the squadron ferried returning military personnel to Morrison Field, Florida, where they were sent on to other bases or prepared for separation after the war. Inactivated at the end of July 1945.

Apparently not manned, 1947–1948. Activated by Far East Air Force in 1952 as a combat resupply and transport squadron, based in Japan. Provided aerial transportation between Japan and Korea during the Korean War with C-46 Commandos. Inactivated in 1955 in Japan.

Combat Operations. Included airborne assaults on Normandy, the Netherlands, and Germany, as well as aerial transportation in ETO and MTO, during World War II. Apparently not manned, 1947–1948. Aerial transportation between Japan and Korea during Korean War.