Didrex

INDICATIONS

DIDREX (benzphetamine) Tablets are indicated in the management of exogenous obesity as a short
term (a few weeks) adjunct in a regimen of weight reduction based on caloric
restriction in patients with an initial body mass index (BMI) of 30 kg/m²
or higher who have not responded to appropriate weight reducing regimen (diet
and/or exercise) alone. Below is a chart of Body Mass Index (BMI) based on various
heights and weights. BMI is calculated by taking the patient's weight, in kilograms
(kg), divided by the patient's height, in meters (m), squared. Metric conversions
are as follows: pounds ÷ 2.2 = kg; inches × 0.0254 = meters. The limited usefulness
of agents of this class (See CLINICAL PHARMACOLOGY) should be weighed
against possible risks inherent in their use such as those described below.

BODY MASS INDEX (BMI), kg/m²

Weight (pounds)

Height (feet, inches)

5'0”

5'3”

5'6”

5'9”

6'0”

6'3”

140

27

25

23

21

19

18

150

29

27

24

22

20

19

160

31

28

26

24

22

20

170

33

30

28

25

23

21

180

35

32

29

27

25

23

190

37

34

31

28

26

24

200

39

36

32

30

27

25

210

41

37

34

31

29

26

220

43

39

36

33

30

28

230

45

41

37

34

31

29

240

47

43

39

36

33

30

250

49

44

40

37

34

31

DIDREX (benzphetamine) Tablets are indicated for use as monotherapy only.

DOSAGE AND ADMINISTRATION

Dosage should be individualized according to the response of the patient. The
suggested dosage ranges from 25 to 50 mg one to three times daily. Treatment
should begin with 25 to 50 mg once daily with subsequent increase in individual
dose or frequency according to response. A single daily dose is preferably given
in mid-morning or mid-afternoon, according to the patient's eating habits. In
an occasional patient it may be desirable to avoid late afternoon administration.
Use of benzphetamine hydrochloride is not recommended in individuals under 12
years of age.