ABSTRACT:Background: polycystic ovarian syndrome (PCOS) is a common endocrine disorder among women in reproductive age group, in which hormones are out of balance. It can cause problems with periods and make it difficult to get pregnant. If it is not treated, it can lead to serious health problems over a period of time. Early diagnosis and treatment can help to control the symptoms and prevent long term problems1. So, nurses are in a position to provide comprehensive care to adolescents affected with PCOS. The aim of the study was to assess the knowledge of nursing college students regarding PCOS and to associate the level of knowledge with their demographic variables. Methodology: Quantitative approach and descriptive design was used to assess the knowledge regarding PCOS, in a selected College of nursing in April 2018. Totally ninety two male and female students from III and IV year B. Sc (N) were selected by using convenient sampling technique. A structured knowledge questionnaire was used to collect data. Results: Among 92 nursing college students, 86 (93.47%) students had inadequate knowledge regarding PCOS and significant association was found between the knowledge of PCOS with their demographic variables like previous knowledge about PCOS (?2=472.08) and family history with PCOS (?2=12.53) at 0.05 level of significance. Conclusions: Majority of the nursing college students had inadequate knowledge with regard to polycystic ovarian syndrome. Significant association is there between the knowledge of nursing college students on PCOS and their previous knowledge about PCOS and family history of PCOS.