Objective:

The Health Effects Institute (HEI) is an independent, nonprofit corporation
chartered in 1980 to provide high-quality, impartial, and relevant science on
the health effects of pollutants from motor vehicles and from other sources in
the environment. Supported jointly by the U.S. Environmental Protection Agency
(EPA) and industry (manufacturers and marketers of motor vehicles or engines),
HEI has funded over 170 studies and published over 100 Research Reports, and
several Special Reports, producing important research findings on the health
effects of a variety of pollutants, including carbon monoxide, methanol and
aldehydes, nitrogen oxides, diesel exhaust, ozone, and most recently,
particulate air pollution.

HEI has also been called upon periodically to produce special reports
reviewing an entire area of scientific literature on topics such as the health
effects of asbestos, diesel exhaust, and oxygenates in fuel.

To accomplish its mission, HEI:- Identifies the highest priority areas
for health effects research;- Funds and oversees the conduct of high-quality
research in these priority areas;- Provides intensive, independent review of
HEI-supported and related research;- Integrates HEI's research results with
those of other institutions into coherent, broader evaluations of health
effects; and Communicates the results of HEI researchand analyses to public
and private decision makers.

The HEI research program has addressed questions about the health effects
associated with exposure to both regulated pollutants such as carbon monoxide,
ozone, and nitrogen dioxide, and unregulated pollutants such as diesel exhaust,
aldehydes, and methanol. HEI has also funded studies to understand the
mechanisms of diseases, to develop better methods to assess health effects and
determine dose response relationships. The program has included theoretical, in
vitro, animal, controlled human exposure, and epidemiological studies.

The center has conducted research in several areas, including:Mobile
Source Air toxics - which includes research on benzene and 1,3-butadiene,
mechanisms of carcinogenicity and biomarkers of dose and effect, and the health
effects of aldehydes; Oxygenated Fuels - the comparative metabolism and health
effects of ethers used to increase gasoline oxygen content (MTBE); and
Particulates - health effects of particulate air pollution and potential
relationship to increased daily mortality.

HEI's Board of Directors, chaired by Richard Celeste, consists of public
figures in science and policy who are committed to the public-private
partnership that is central to the HEI approach. The Institute's scientific work
is overseen by two independent scientific committees. The Health Research
Committee works with the Institute's scientific staff to develop and manage
HEI's research program. The Health Review Committee which has no role in
selecting or overseeing studies, works with the Institute's scientific staff to
evaluate and interpret the results of HEI studies and related research. HEI's
priorities for research and special reviews are guided by the five-year HEI
Strategic Plan , which is reviewed and updated annually after consultations with
HEI sponsors and other interested parties.

Progress and Final Reports:

Subprojects under this Center:(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).R828112C042 Does Inhalation of Methanol Vapor Affect Human Neurobehavior?R828112C043 Human Responses to Nitrogen DioxideR828112C044 The Role of Inflammation in Ozone-Induced Lung InjuryR828112C045 How Does Exercise Affect the Dose of Inhaled Air Pollutants?R828112C046 How Do Chemicals in Diesel Engine Exhaust Damage DNA?R828112C047 Effect of Nitrogen Dioxide on Bacterial Respiratory infection
in MiceR828112C048 Effects of Ozone Exposure on Airway EpitheliumR828112C049 Inhalation of Aldehydes and Effects on BreathingR828112C050 Does Ozone Cause Precancerous Changes in Cells?R828112C051 Effects of Formaldehyde on Human Airway Epithelial Cells Exposed in a Novel Culture SystemR828112C052 Carbon Monoxide and Cardiac ArrhythmiasR828112C053 Effects of Formaldehyde and Particle-Bound Formaldehyde on Lung Macrophage FunctionsR828112C054 Mechanisms for Protecting Lung Epithelial Cells Against Oxidant InjuryR828112C055 Relationship of Nitropyrene-Derived DNA Adducts to CarcinogenesisR828112C056 Particle Trap Effects on Heavy-Duty Diesel Engine EmissionsR828112C057 Carbon Monoxide and AtherosclerosisR828112C058 Nitrogen Dioxide and Respiratory Illness in ChildrenR828112C059 Noninvasive Methods for Measuring Ventilation in Mobile SubjectsR828112C060 Oxidant Air Pollutants and Lung Cancer: An Animal ModelR828112C061 Detection of Carcinogen-DNA Adducts: Development of New MethodsR828112C062 Effects of Carbon Monoxide on Heart Muscle CellsR828112C063 Development of Personal Ozone Samplers: Three ApproachesR828112C064 Development of Biomarkers to Monitor Carcinogen ExposureR828112C065 Effects of Prolonged Ozone Inhalation on Collagen Structure and Content in Rat LungsR828112C065II Prolonged Ozone Exposure and the Contractile Properties of Isolated Rat AirwaysR828112C065III Changes in Complex Carbohydrate Content and Structure in Rat Lungs Caused by Prolonged Ozone InhalationR828112C065IV Genetic Control of Connective Tissue Protein Synthesis After Prolonged Ozone InhalationR828112C065V Pulmonary Function Alterations in Rats After Chronic Ozone InhalationR828112C065VII Prolonged Ozone Exposure Leads to Functional and Structural Changes in the Rat NoseR828112C065VIII - IX Studies of Changes in Lung Structure and Enzyme Activitiesin Rats After Prolonged Exposure to OzoneR828112C065X An Innovative Approach to Analyzing Multiple Experimental Outcomes: A Case Study of Rats Exposed to OzoneR828112C065XI The Consequences of Prolonged Inhalation of Ozone on Rats:
An Integrative Summary of the Results of Eight Collaborative StudiesR828112C066 Interactive Effects of Nitropyrenes in Diesel ExhaustR828112C067 Detection of FormaldehydeDNA Adducts: Development of New MethodsR828112C068I Comparison of the Carcinogenicity of Diesel Exhaust and Carbon Black in Rat LungsR828112C068II An Investigation of DNA Damage in the Lungs of Rats Exposed to Diesel ExhaustR828112C068III No Evidence For Genetic Mutations Found In Lung Tumors From Rats Exposed To Diesel Exhaust or Carbon BlackR828112C069 Noninvasive Determination of Respiratory Ozone Absorption: The Bolus-Response MethodR828112C070 The Effects of Inhaled Oxidants and Acid Aerosols on Pulmonary FunctionR828112C071 Biochemical Consequences of Ozone Reacting with Membrane Fatty AcidsR828112C072 DNA Mutations in Rats Treated with a Carcinogen Present in Diesel ExhaustR828112C073 Developmental Neurotoxicity of Inhaled Methanol in RatsR828112C074 Methanol Distribution in Non Pregnant and Pregnant RodentsR828112C075 Is Increased Mortality Associated with Ozone Exposure in Mexico City?R828112C076 Effects of Fuel Modification and Emission Control Devices on Heavy-Duty Diesel Engine EmissionsR828112C077 Metabolic Studies in Monkeys Exposed to Methanol VaporsR828112C078 Effects of Ozone on Pulmonary Function and Airway Inflammation in Normal and Potentially Sensitive Human SubjectsR828112C079 Improvement of a Respiratory Ozone AnalyzerR828112C080 Mechanism of Oxidative Stress from Low Levels of Carbon MonoxideR828112C081 Long-Term Exposure to Ozone: Development of Methods to Estimate Past Exposures and Health OutcomesR828112C082 Effects of Ambient Ozone on Healthy, Wheezy, and Asthmatic ChildrenR828112C083 Daily Changes in Oxygen Saturation and Pulse Rate Associated with Particulate Air Pollution and Barometric PressureR828112C084 Evaluation of The Potential Health Effects of the Atmospheric Reaction Products of Polycyclic Aromatic HydrocarbonsR828112C085 Mechanisms of Response to Ozone Exposure: The Role of Mast Cells in MiceR828112C086 Statistical Methods for Epidemiologic Studies of the Health Effects of Air PollutionR828112C087 Development of New Methods to Measure Benzene BiomarkersR828112C088 Alveolar Changes in Rat Lungs After Long-Term Exposure to Nitric OxideR828112C089 Effects of Prenatal Exposure to Inhaled Methanol on Nonhuman Primates and Their Infant OffspringR828112C090 A Pilot Study of Potential Biomarkers of Ozone ExposureR828112C091 Effects of Concentrated Ambient Particles on the Cardiac and Pulmonary Systems of DogsR828112C092 Cancer, Mutations, and Adducts in Rats and Mice Exposed to Butadiene and Its MetabolitesR828112C093 Effects of Concentrated Ambient Particles in Rats and Hamsters: An Exploratory StudyR828112C094I The National Morbidity, Mortality, and Air Pollution Study: Methods and Methodologic IssuesR828112C094II The National Morbidity, Mortality, and Air Pollution Study: Morbidity and Mortality from Air Pollution in the United StatesR828112C095 Association of Particulate Matter Components with Daily Mortality and Morbidity in Urban PopulationsR828112C096 Acute Pulmonary Effects of Ultrafine Particles in Rats and MiceR828112C097 Identifying Subgroups of the General Population That May Be Susceptible to Short-Term Increases in Particulate Air PollutionR828112C098 Daily Mortality and Fine and Ultrafine Particles in Erfurt, GermanyR828112C099 A Case-Crossover Analysis of Fine Particulate Matter Air Pollution and Out-of-Hospital Sudden Cardiac ArrestR828112C100 Effects of Mexico City Air on Rat NoseR828112C101 Penetration of Lung Lining and Clearance of Particles Containing Benzo[a]pyreneR828112C102 Metabolism of Ether Oxygenates Added to GasolineR828112C103 Characterization and Mechanisms of Chromosomal Alterations Induced by Benzene in Mice and HumansR828112C104 Acute Cardiovascular Effects in Rats from Exposure to Urban Ambient ParticlesR828112C105 Genetic Differences in Induction of Acute Lung Injury and Inflammation in MiceR828112C106 Effects on Mice of Exposure to Ozone and Ambient Particle PollutionR828112C107 Emissions from Diesel and Gasoline Engines Measured in Highway TunnelsR828112C108 Case-Cohort Study of Styrene Exposure and Ischemic Heart Disease InvestigatorsR828112C110 Effects of Metals Bound to Particulate Matter on Human Lung Epithelial CellsR828112C111 Effect of Concentrated Ambient Particulate Matter on Blood Coagulation Parameters in RatsR828112C112 Health Effects of Acute Exposure to Air PollutionR828112C113 Benzene Metabolism in Rodents at Doses Relevant to Human Exposure from Urban AirR828112C114 A Personal Particle Speciation SamplerR828112C115 Validation and Evaluation of Biomarkers in Workers Exposed to Benzene in ChinaR828112C116 Biomarkers in Czech Workers Exposed to 1,3-Butadiene: A Transitional Epidemiologic StudyR828112C117 Peroxides and Macrophages in the Toxicity of Fine Particulate Matter in RatsR828112C118 Controlled Exposures of Healthy and Asthmatic Volunteers to Concentrated Ambient Particles in Metropolitan Los AngelesR828112C119 Manganese Toxicokinetics at the Blood-Brain BarrierR828112C120 Effects of Exposure to Concentrated Ambient Particles from Detroit Air on Healthy Rats and Rats with Features of Asthma or Mild BronchitisR828112C121 Field Evaluation of Nanofilm Detectors for Measuring Acidic Particles in Indoor and Outdoor AirR828112C123 Time-Series Analysis of Air Pollution and Mortality: A Statistical ReviewR828112C126 Effects of Exposure to Ultrafine Carbon Particles in Healthy Subjects and Subjects with AsthmaR828112C128 Neurogenic Responses of Rat Lung to Diesel ExhaustR828112C130-I Relationships of Indoor, Outdoor, and Personal Air (RIOPA). Part I. Collection Methods and Descriptive AnalysesR828112C132 An Updated Study of Mortality Among North American Synthetic Rubber Industry Workers

The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.