Form 8.3 - SHIRE PLC

A PERSON WITH INTERESTS IN RELEVANT SECURITIES REPRESENTING 1% OR MORE

Rule 8.3 of the Takeover Code (the “Code”)

1. KEY INFORMATION

(a)

Full name of discloser:

Barclays PLC.

(b)

Owner or controller of interest and short

positions disclosed, if different from 1(a):

(c)

Name of offeror/offeree in relation to whose

SHIRE PLC

relevant securities this form relates:

(d)

If an exempt fund manager connected with an

offeror/offeree, state this and specify identity of

offeror/offeree:

(e)

Date position held/dealing undertaken:

14 May 2018

(f)

In addition to the company in 1(c) above, is the discloser making

YES:

disclosures in respect of any other party to the offer?

TAKEDA PHARMACEUTICAL CO LTD

2. POSITIONS OF THE PERSON MAKING THE DISCLOSURE

If there are positions or rights to subscribe to disclose in more
than one class of relevant securities of the offeror or offeree named in
1(c), copy table 2(a) or (b) (as appropriate) for each additional class
of relevant security.

(a) Interests and short positions in the relevant securities of the
offeror or offeree to which the disclosure relates following the dealing
(if any)

Class of relevant security:

5p ordinary

Interests

Short Positions

Number

(%)

Number

(%)

(1)

Relevant securities owned

and/or controlled:

8,196,731

0.86%

2,822,717

0.31%

(2)

Cash-settled derivatives:

298,099

0.03%

4,119,013

0.45%

(3)

Stock-settled derivatives (including options)

and agreements to purchase/sell:

356,400

0.04%

665,800

0.07%

TOTAL:

8,851,230

1.93%

7,607,530

0.83%

All interests and all short positions should be disclosed.

Details of any open stock-settled derivative positions (including
traded options), or agreements to purchase or sell relevant securities,
should be given on a Supplemental Form 8 (Open Positions).

(b) Rights to subscribe for new securities (including directors’ and
other employee options)

Class of relevant security in relation to which subscription right
exists:

Details, including nature of the rights concerned and relevant
percentages:

3. DEALINGS (IF ANY) BY THE PERSON MAKING THE DISCLOSURE

Where there have been dealings in more than one class of relevant
securities of the offeror or offeree named in 1(c), copy table 3(a),
(b), (c) or (d) (as appropriate) for each additional class of relevant
security dealt in.

The currency of all prices and other monetary amounts should be
stated.

(a) Purchases and sales

Class of relevant

Purchase/sale

Number of

Price per unit

security

securities

ADR

Purchase

74

169.4400 USD

ADR

Purchase

100

168.6900 USD

ADR

Purchase

100

168.6300 USD

ADR

Purchase

100

168.6800 USD

ADR

Purchase

140

168.4971 USD

ADR

Purchase

144

168.8586 USD

ADR

Purchase

200

168.9900 USD

ADR

Purchase

200

168.9300 USD

ADR

Purchase

200

168.9875 USD

5p ordinary

Purchase

223

41.1977 GBP

5p ordinary

Purchase

228

41.4300 GBP

5p ordinary

Purchase

235

41.2723 GBP

ADR

Purchase

283

168.2395 USD

ADR

Purchase

300

168.4241 USD

5p ordinary

Purchase

397

41.0138 GBP

ADR

Purchase

400

168.8900 USD

ADR

Purchase

400

168.8175 USD

5p ordinary

Purchase

418

41.0691 GBP

ADR

Purchase

476

168.6788 USD

5p ordinary

Purchase

595

41.0632 GBP

5p ordinary

Purchase

768

41.1299 GBP

5p ordinary

Purchase

777

41.4025 GBP

ADR

Purchase

800

168.6425 USD

5p ordinary

Purchase

823

41.1459 GBP

5p ordinary

Purchase

947

41.1492 GBP

ADR

Purchase

1,000

168.5310 USD

5p ordinary

Purchase

1,091

41.0874 GBP

ADR

Purchase

1,372

168.8451 USD

5p ordinary

Purchase

1,575

40.8134 GBP

5p ordinary

Purchase

1,684

40.9852 GBP

ADR

Purchase

2,075

168.5200 USD

5p ordinary

Purchase

2,193

40.7687 GBP

5p ordinary

Purchase

2,229

41.0367 GBP

ADR

Purchase

2,300

168.7571 USD

ADR

Purchase

2,522

168.6282 USD

5p ordinary

Purchase

3,088

41.0687 GBP

ADR

Purchase

3,230

168.6594 USD

5p ordinary

Purchase

3,751

41.0273 GBP

ADR

Purchase

3,755

168.8691 USD

5p ordinary

Purchase

3,855

40.9544 GBP

ADR

Purchase

3,944

168.5793 USD

5p ordinary

Purchase

4,509

41.0395 GBP

ADR

Purchase

4,700

168.6673 USD

ADR

Purchase

6,500

168.9262 USD

5p ordinary

Purchase

7,228

41.0230 GBP

5p ordinary

Purchase

7,912

41.3700 GBP

ADR

Purchase

9,000

168.9462 USD

ADR

Purchase

11,100

168.8233 USD

5p ordinary

Purchase

12,476

40.7919 GBP

5p ordinary

Purchase

12,500

41.3347 GBP

ADR

Purchase

13,886

168.7226 USD

5p ordinary

Purchase

13,958

41.0749 GBP

5p ordinary

Purchase

14,900

41.2600 GBP

5p ordinary

Purchase

15,000

40.9227 GBP

ADR

Purchase

15,742

168.5176 USD

5p ordinary

Purchase

21,037

41.0432 GBP

5p ordinary

Purchase

34,128

40.8017 GBP

ADR

Purchase

42,339

168.7046 USD

5p ordinary

Purchase

72,053

41.3049 GBP

5p ordinary

Purchase

74,268

41.0978 GBP

5p ordinary

Purchase

218,554

41.1676 GBP

ADR

Sale

44

169.3101 USD

5p ordinary

Sale

51

40.8050 GBP

ADR

Sale

74

169.4400 USD

ADR

Sale

78

168.3858 USD

ADR

Sale

100

167.2100 USD

ADR

Sale

100

168.5700 USD

ADR

Sale

100

168.7500 USD

ADR

Sale

100

168.8400 USD

ADR

Sale

100

168.8500 USD

ADR

Sale

100

169.0100 USD

ADR

Sale

100

170.1100 USD

5p ordinary

Sale

160

40.8550 GBP

5p ordinary

Sale

170

40.9444 GBP

ADR

Sale

200

168.9500 USD

ADR

Sale

200

168.5900 USD

ADR

Sale

283

168.2395 USD

ADR

Sale

300

169.2650 USD

ADR

Sale

300

168.9366 USD

5p ordinary

Sale

376

40.9721 GBP

ADR

Sale

400

168.7731 USD

ADR

Sale

400

168.9900 USD

ADR

Sale

400

168.9087 USD

5p ordinary

Sale

465

41.2092 GBP

5p ordinary

Sale

516

40.8006 GBP

5p ordinary

Sale

583

41.1642 GBP

ADR

Sale

700

168.9471 USD

ADR

Sale

700

168.9571 USD

5p ordinary

Sale

717

41.4244 GBP

ADR

Sale

800

169.0075 USD

ADR

Sale

1,018

168.9417 USD

5p ordinary

Sale

1,099

40.7995 GBP

ADR

Sale

1,182

168.9300 USD

ADR

Sale

1,200

169.4866 USD

5p ordinary

Sale

1,332

41.0952 GBP

5p ordinary

Sale

1,377

41.0750 GBP

ADR

Sale

1,446

168.5200 USD

5p ordinary

Sale

1,473

40.8108 GBP

ADR

Sale

1,500

168.8076 USD

ADR

Sale

2,022

168.7682 USD

ADR

Sale

2,115

168.6864 USD

5p ordinary

Sale

3,009

41.0833 GBP

ADR

Sale

3,500

168.6208 USD

5p ordinary

Sale

3,656

41.3700 GBP

ADR

Sale

3,871

168.4785 USD

ADR

Sale

4,500

168.9462 USD

5p ordinary

Sale

4,800

41.0507 GBP

5p ordinary

Sale

5,000

40.7949 GBP

ADR

Sale

5,800

168.7886 USD

ADR

Sale

5,800

168.8597 USD

ADR

Sale

6,000

168.9125 USD

5p ordinary

Sale

7,149

41.2760 GBP

5p ordinary

Sale

7,500

41.3811 GBP

ADR

Sale

7,583

168.6446 USD

ADR

Sale

10,547

168.4749 USD

5p ordinary

Sale

12,332

41.0994 GBP

5p ordinary

Sale

14,138

41.0756 GBP

5p ordinary

Sale

25,809

41.3493 GBP

5p ordinary

Sale

30,049

41.3073 GBP

ADR

Sale

31,011

168.6778 USD

5p ordinary

Sale

32,462

40.8018 GBP

ADR

Sale

32,708

168.7205 USD

5p ordinary

Sale

32,998

40.9100 GBP

5p ordinary

Sale

47,733

41.1645 GBP

5p ordinary

Sale

51,615

41.1439 GBP

5p ordinary

Sale

53,959

41.0234 GBP

5p ordinary

Sale

57,533

41.3718 GBP

(b) Cash-settled derivative transactions

Class of

Product

Nature of dealing

Number of

Price per

relevant

description

reference

unit

security

securities

5p ordinary

SWAP

Long

17

41.3682 GBP

5p ordinary

SWAP

Long

361

41.3700 GBP

5p ordinary

CFD

Long

376

40.9721 GBP

5p ordinary

SWAP

Long

1,332

41.0951 GBP

5p ordinary

SWAP

Long

1,711

40.9707 GBP

5p ordinary

CFD

Long

2,664

40.9973 GBP

5p ordinary

SWAP

Long

2,681

41.3514 GBP

5p ordinary

SWAP

Long

4,246

41.0511 GBP

5p ordinary

SWAP

Long

5,130

41.0849 GBP

5p ordinary

SWAP

Long

5,453

41.0236 GBP

5p ordinary

CFD

Long

7,500

41.3811 GBP

5p ordinary

CFD

Long

25,809

41.3493 GBP

5p ordinary

SWAP

Long

44,457

41.1859 GBP

5p ordinary

SWAP

Short

299

41.1816 GBP

5p ordinary

SWAP

Short

596

41.2622 GBP

5p ordinary

CFD

Short

601

41.1522 GBP

5p ordinary

CFD

Short

1,091

41.0874 GBP

5p ordinary

SWAP

Short

1,778

41.0757 GBP

5p ordinary

CFD

Short

2,193

40.7687 GBP

5p ordinary

SWAP

Short

2,588

41.3700 GBP

5p ordinary

SWAP

Short

3,027

41.0317 GBP

5p ordinary

SWAP

Short

5,132

40.9068 GBP

5p ordinary

CFD

Short

7,228

41.0230 GBP

5p ordinary

CFD

Short

16,338

41.3733 GBP

5p ordinary

SWAP

Short

25,442

41.1535 GBP

5p ordinary

CFD

Short

74,109

41.3637 GBP

5p ordinary

CFD

Short

74,726

40.9760 GBP

(c) Stock-settled derivative transactions (including options)

(i) Writing, selling, purchasing or varying

Class

Product

Writing,

Number

Exercise

Type

Expiry

Option

of

description

purchasing,

of

price

date

money

relevant

selling,

securities

per unit

paid/

security

varying etc

to which

received

option

per unit

relates

ADR

Call Options

Purchasing

1,800

165 USD

American

20 Jul 2018

9.4000 USD

ADR

Call Options

Purchasing

1,000

170 USD

American

18 May 2018

1.1000 USD

ADR

Put Options

Selling

500

95 USD

American

20 Jul 2018

0.1000 USD

ADR

Put Options

Selling

2,400

158 USD

American

18 May 2018

0.0900 USD

(ii) Exercise

Class of relevant security

Product description

e.g. call option

Exercising/ exercised against

Number of securities

Exercise price per unit

(d) Other dealings (including subscribing for new securities)

Class of relevant security

Nature of dealing

e.g. subscription, conversion

Details

Price per unit (if applicable)

4. OTHER INFORMATION

(a) Indemnity and other dealing arrangements

Details of any indemnity or option arrangement, or any agreement or
understanding, formal or informal, relating to relevant securities
which may be an inducement to deal or refrain from dealing entered
into by the person making the disclosure and any party to the offer
or any person acting in concert with a party to the offer:

Irrevocable commitments and letters of intent should not be
included. If there are no such agreements, arrangements or
understandings, state “none”

None

(b) Agreements, arrangements or understandings relating to options or
derivatives

Details of any agreement, arrangement or understanding, formal or
informal, between the person making the disclosure and any other
person relating to:

(i) the voting rights of any relevant securities under any option;
or

(ii) the voting rights or future acquisition or disposal of any
relevant securities to which any derivative is referenced:

If there are no such agreements, arrangements or
understandings, state “none”

None

(c) Attachments

Is a Supplemental Form 8 (Open Positions) attached?

YES

Date of disclosure:

15 May 2018

Contact name:

Jay Supaya

Telephone number:

020 7773 0635

Public disclosures under Rule 8 of the Code must be made to a
Regulatory Information Service.

The Panel’s Market Surveillance Unit is available for consultation in
relation to the Code’s disclosure requirements on +44 (0)20 7638 0129.