Target details

Target details

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Alternative Name

WHSC1

Background

WHSC1 encodes a protein that contains four domains present in other developmental proteins: a PWWP domain, an HMG box, a SET domain, and a PHD-type zinc finger. It is expressed ubiquitously in early development. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4.Synonyms: KIAA1090, MMSET, Multiple myeloma SET domain-containing protein, NSD2, Nuclear SET domain-containing protein 2, Probable histone-lysine N-methyltransferase NSD2, TRX5, Trithorax-5, Wolf-Hirschhorn syndrome candidate 1 protein