A case of pleomorphic lipoma of the tongue in a 60-year-old woman is reported. Recently described by Enzinger (1977), pleomorphic lipoma is a rare benign tumor, occurring mostly in elderly males. The subcutaneous tissues of the neck and back are the most common sites involved. Differentiation from some histological variants of liposarcoma remains difficult. Complete surgical excision is the treatment of choice. To our knowledge, this is the first case of pleomorphic lipoma of the tongue reported in the English literature.