What this means: In this systematic review of stem cell therapy for orthopedic issues, almost 1000 patients were treated with no significant adverse events with treatment. Support in the literature is strongest for the use of bone marrow aspirate concentrate (BMAC) injections for the treatment of knee pain, but also showed improved symptoms for those with hip, tendon and spinal disc pain.

What this means: Osteoarthritis has one of the highest associations for all-cause mortality, and decreased quality of life, in the United States. With advancements in Orthobiologic treatments, such as stem cell therapy, they should be considered as potential “step therapies” for patients wanting to delay joint replacement surgery.

The effectiveness of prolotherapy in treating knee osteoarthritis in adults: a systematic review.

What this means: Osteoarthritis (OA) often leads to symptoms such as pain, stiffness and decreased function. Moderate evidence suggests that prolotherapy is safe and can help achieve significant symptomatic control in individuals with OA.

What this means: Although we are not goats, animal models are used as the gold standard to test and perfect novel therapies. This study showed that intraarticular (inside the knee) injection of autologous PRP (platelet rich plasma) and BMC (bone marrow concentrate) has therapeutic efficacy in a goat osteoarthritis model, with the greater benefit in terms of cartilage protection being observed in the BMC-treated group than PRP.

What this means: This study shows that both ultrasound-guided tendon fenestration and platelet rich plasma (PRP) injection are effective for treatment of gluteal tendinosis, showing symptom improvement in both treatment groups.

What this means: Intra-articular injections of PRP resulted in no serious adverse effects and significantly reduced pain in the patients with ankle osteoarthritis( OA). Platelet Rich Plasma (PRP) treatment is a safe and effective option in the treatment of ankle OA.

What this means: In the treatment of plantar fasciitis, Platelet rich plasma (PRP) injections are associated with improved pain and function scores at three month follow-up when compared with corticosteroid injections.

OSTEOARTHRITIS | Research and Science

The effectiveness of prolotherapy in treating knee osteoarthritis in adults: a systematic review.

What this means: Osteoarthritis (OA) often leads to symptoms such as pain, stiffness and decreased function. Moderate evidence suggests that prolotherapy is safe and can help achieve significant symptomatic control in individuals with OA.

What this means: Although we are not goats, animal models are used as the gold standard to test and perfect novel therapies. This study showed that intraarticular (inside the knee) injection of autologous PRP (platelet rich plasma) and BMC (bone marrow concentrate) has therapeutic efficacy in a goat osteoarthritis model, with the greater benefit in terms of cartilage protection being observed in the BMC-treated group than PRP.

What this means: This study shows that both ultrasound-guided tendon fenestration and platelet rich plasma (PRP) injection are effective for treatment of gluteal tendinosis, showing symptom improvement in both treatment groups.

What this means: Contrary to what companies are marketing regarding umbilical cord derived stem cells (or growth factor products) being superior in the elderly population, these results suggest that it is feasible to obtain large numbers of high-quality autologous MSCs from the elderly population. Further, it would be highly beneficial for the aging patient to establish personal stem cell banks that will allow serial infusions of “rejuvenated” MSCs for treating age-related diseases.

Musculoskeletal Injuries and Regenerative Medicine in the Elderly Patient.

What this means: Over the past decade or more in the U.S., Regenerative Orthopedic procedures including stem cell therapy, platelet rich plasma (PRP), and prolotherapy have been effectively used as non-surgical interventions to treat orthopedic problems in an aging population.

What this means: In this systematic review of stem cell therapy for orthopedic issues, almost 1000 patients were treated with no significant adverse events with treatment. Support in the literature is strongest for the use of bone marrow aspirate concentrate (BMAC) injections for the treatment of knee pain, but also showed improved symptoms for those with hip, tendon and spinal disc pain.

What this means: Although we are not goats, animal models are used as the gold standard to test and perfect novel therapies. This study showed that intraarticular (inside the knee) injection of autologous PRP (platelet rich plasma) and BMC (bone marrow concentrate) has therapeutic efficacy in a goat osteoarthritis model, with the greater benefit in terms of cartilage protection being observed in the BMC-treated group than PRP.

What this means: Although we are not goats, animal models are used as the gold standard to test and perfect novel therapies. This study showed that intraarticular (inside the knee) injection of autologous PRP (platelet rich plasma) and BMC (bone marrow concentrate) has therapeutic efficacy in a goat osteoarthritis model, with the greater benefit in terms of cartilage protection being observed in the BMC-treated group than PRP.

What this means: This study shows that both ultrasound-guided tendon fenestration and platelet rich plasma (PRP) injection are effective for treatment of gluteal tendinosis, showing symptom improvement in both treatment groups.

What this means: Intra-articular injections of PRP resulted in no serious adverse effects and significantly reduced pain in the patients with ankle osteoarthritis( OA). Platelet Rich Plasma (PRP) treatment is a safe and effective option in the treatment of ankle OA.

What this means: In the treatment of plantar fasciitis, Platelet rich plasma (PRP) injections are associated with improved pain and function scores at three month follow-up when compared with corticosteroid injections.

PROLOTHERAPY | Research and Science

The effectiveness of prolotherapy in treating knee osteoarthritis in adults: a systematic review.

What this means: Osteoarthritis (OA) often leads to symptoms such as pain, stiffness and decreased function. Moderate evidence suggests that prolotherapy is safe and can help achieve significant symptomatic control in individuals with OA.

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