Certain antidepressants can help reduce pain caused by a damaged nerve.

Anticonvulsants, such as gabapentin, manage nerve pain.

Corticosteroids, for example prednisone, may reduce inflammation.

Bone-loss prevention medications such as alendronate (Fosamax) and calcitonin (Miacalcin) may be prescribed.

Sympathetic nerve-blocking drugs, such as an anesthetic, may be injected to block the nerve fibers in the affected nerves.

Opioid medications, or opiates are strong painkillers that include morphine, codeine, oxycodone, and methadone. Codeine and diamorphine offer short-term pain relief for severe CRPS, but due to the risk of addiction and other side effects, they should be used with caution and only in the short term.