Hollegaard et al. have demonstrated in the past that DNA extracted from a fraction (2 × 3.2 mm discs) of an archived Dried blood spot sample (DBSS) can be whole genome amplified (wgaDNA) and used for accurate array genotyping. In this study, they compared whole-blood DNA next-generation sequencing (NGS) results to results from DBSS and concluded that DBSS can be used for NGS. The overall performance of the archived DBSS was reported to be similar to the whole blood reference sample. According to Hollegaard et al. two 3.2 mm disks from a DBSS is sufficient for WGA, and subsequently Whole Exome/Genome Sequencing.