For the last quarter century, researchers have been asking whether genomic information might have negative psychosocial effects. Anxiety, depression, disrupted relationships, and heightened stigmatization have all been posited as possible outcomes—but not consistently found. At this conference, we will ask what accounts for the discrepancy between these hypothesized outcomes and the effects that have been documented in empirical studies. Are we asking the right questions? Using the right tools? Looking in the right places? Or was the expectation of large, negative psychosocial impacts of genomic information overblown to begin with? Either way, where does research into the ethical and psychosocial implications of genomic medicine go from here?