Taking M1D in conjunction with creatine will have no adverse affects on your body. They don't really interact as both are working through different pathways in your body. Creatine converts to ATP for added fuel in your muscles, where as M1D is a prohormone. If you plan to run M1D understand that it is a prohormone and therefore I'd recommend at a minimum that you run some form of post cycle therapy. LG's Formadrol Xtreme is a solid choice, but there are plenty of choices out there.