Related Links:

Caplacizumab-yhdp (Cablivi) is the first drug specifically indicated for acquired thrombotic thrombocytopenic purpura, a rare and potentially life-threatening blood clotting disorder. It is prescribed in combination with plasmapheresis and immunosuppressive therapy.The drug carries a warning that severe bleeding can occur with use, although the most common adverse effects are headache and minor bleeding from the nose or gums.Caplacizumab-yhdp is given initially as an iv bolus and then as a subcutaneous injection along with plasmapheresis.

AbstractTo investigate the clinical manifestation, disease course, and prognosis of migraine patients with or without personality disorders. This cross-sectional study evaluated 61 patients with migraine diagnosed according to the criteria of the International Headache Society (IHS). Personality disorders were assessed with the Structured Clinical Interview for DSM-IV (SCID-II). Migraine severity was assessed with the Headache Impact Test-6 (HIT-6). We also used a structured clinical interview to diagnose comorbid mood disorders. Of the 61 patients, 20 (32.8%) had personality disorders. Personality disorders included obses...

People with obsessive-compulsive disorder (OCD) who don ’t achieve adequate relief from medication and cognitive-behavioral therapy may benefit from deep transcranial magnetic stimulation (dTMS), astudy inAJP in Advancesuggests.During dTMS treatment, a cap containing coils delivers magnetic pulses to stimulate nerve cells in the brain. The study compared active dTMS treatment with sham (inactive) treatment in 87 people with OCD, with participants in the active treatment group experiencing greater improvement in symptoms at the end of treatment and at a follow-up assessment four weeks later.The study, led by Lior Carm...

FRIDAY, May 24, 2019 -- Migraines in pregnant women are associated with an increased risk for pregnancy-associated hypertension disorders as well as an increased risk for a variety of adverse outcomes in the newborn, according to a study published...

This study investigates whether METH induces autophagy in the human dopaminergic neuroblastoma cell line SH-SY5Y, then examines the neuroprotective effects of gastrodin against autophagy in METH-treated SH-SY5Y cells. The effects of METH on the protein expressions of autophagy-related genes (LC3B and Beclin-1) were evaluated with and without gastrodin. The presence of autophagosomes in the METH-induced treatment with and without gastrodin is revealed through transmission electron microscopy. Pharmacological intervention was employed to study the role of the AKT/mTOR signaling pathway in the gastrodin-mediated neuroprotecti...