Objectives: The aim of this study was to represent special clinical, epidemiological and laboratory characteristics of CCHF in our cases caused by native Hoti-Kosova virus.

Methods: There are studied 207 patients with Crimean-Congo haemorrhagic fever serologically confirmed (from totally 564 cases with clinical manifestations) which are treated at the Infectious Diseases Clinic of the University Clinical Center of Kosova during period 19892008. Diagnosis of the disease is set based on epidemiological, clinical and laboratory data and is confirmed by serological-viral tests (ELISA, RT-PCR).

Results: With viral examinations, in cooperation with Microbiological Institute of Ljubljana, is isolated a new virus, causer of CCHF in Kosova and is nominated Hoti-Kosova virus, which is different in phylogenesis from other regional types of CCHF viruses. Infection is caused after tick bit. Human transmission is found in 21.2% cases inside family, and in 2.42% of cases between health personnel. Infection is more frequent in males (57.9%) than in females. Diseases has shown severe course with intensive haemorrhagic manifestations: petechie (69.3%), bloody eyeball (49.2%), epistaxis (62.4%), haematemesis (70.5%), melena (78.2%), haematuria (29.2%), metrorrhagia (34.5%), liver disorders like hepatitis and mild renal disorders. Specific manifestations in our cases are: otorrhagia (2.03%), Herpes Febrilis (6.6%), haematoperitoneum (13.2%), pleuritis haemorrhagica (5.6%), pericarditis haemorrhagica (8.6%) and thrombocitosis during period of convalescence (1.5%). There has been high rate of Fatality (23.83%).

Conclusion: Republic of Kosova is endemic zone for CCHF. Disease is caused from native type of virus Hoti-Kosova, closely related to a CCHF virus strain Drosdov. Course of the disease has been severe with specific clinical manifestations and with high Fatality Rate.

Session Details

Date:

16/05/2009

Time:

00:00-00:00

Session name:

19th European Congress of Clinical Microbiology and Infectious Diseases