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Plus, if you plan to stay in academia remember this is one of the few papers on your CV. While having a single-author paper may be appealing to you, it could appear as a red-flag to certain people/departments.

It's also difficult because the end are still uncertain. The argument in the second paper says that the animal research isn't needed for the scientific ends. If the ethical argument ends in a harm benefit analysis, then scientific intuition and expertise still makes it debatable whether we should do this research and to what extent.

Yeah,
Strikes me as ablist, to say those with a disease should have to make that sacrifice. If a human dies under the knife from a mistake that could've been solved on a nhp that strikes me as a tragedy.

:(. I'm the slower metabolizer but I love coffee. Will need to keep it in check I guess, especially once I reach the age that heart attack risk is significant.

Sorry to hear your last comment. Have dealt with that shit as well. Actually that's what stops me from taking melatonin anymore.

https://www.reddit.com/r/SuicideWatch/ If there's someone you trust reach out to them. You may feel afraid of burdening others, but when you feel depressed you imagine every situation as worse than it is. You may be surprised how much people are willing and able to help. Ultimately though seeing a psychiatrist and therapist are the best.