She appeared in 46 silent films and 11 talkies, including hits such as Mantrap (1926), It(1927) and Wings(1927). At the high point of her career, she received more than 45,000 fan letters during the month of January 1929.

Bow retired from acting and became a rancher in Nevada. Her final film, Hoop-La, was released in 1933. In September 1965, Bow died of a heart attack at the age of 60.