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One of my main concerns, is weather or not the CMD / Run does anything.

Probably not as much as you might at first think. What you have done is removed the immediate acess to a utility for a particular user or user group. The utility is still there, and they could probably (?) still run it using a different route.

I may well be wrong, but I would normally associate what you have done with limiting users at the physical access level................ at least with NT 4.0 and Windows 2000 Pro. I am not so sure about XP, and haven't even tried with Vista, W7 or W8.

A few more random thoughts:

1. Rename the administrator account.............. it's hard to find something you don't know the name of?

3. Create a backup image and keep it up to date. It's a lot easier to wipe and re-image if the worst happens

4. Possibly total overkill, but you might look at "Deep Freeze" or similar utility? I know there is a free one out there, but I cannot remember its name.

It holds an image of the "clean" system, and re-installs it on reboot. It is used a lot in schools, public libraries and the like, as it automatically kills keyloggers, sniffers and other malware. This works particularly well if you have stroked your hard drive.

If you cannot do someone any good: don't do them any harm....
As long as you did this to one of these, the least of my little ones............you did it unto Me.
What profiteth a man if he gains the entire World at the expense of his immortal soul?