We have mapped chlorpropamide to SUR1 (ABCC8) as this is the drug's likely molecular target, based on the observations that the pancreatic β-cell ATP-sensitive K+ channel is hetero-octomer of 4 SUR1 subunits and 4 Kir6.2 subunits [1], and that chlorpropamide is a sulfonylurea family drug. We have however, been unable to find affinity data to confirm this proposed interaction.