Prenatal testing for infectious disease: TORCH revisited

Summary: Prenatal testing for infectious disease commonly involves screening the mother for infections associated with failed fetal development or congenital abnormalities that may manifest at birth or later in life. Screening often includes testing for the major components of the TORCH complex, along with organisms such as hepatitis B and HIV. Timing of the infection is critical as fetal damage often depends on the gestational age at which infection takes place. Maternal serologic tests can often identify infections that pose a risk to the fetus. Effective treatment can both reduce risk of transmission to the newborn as well as improve management of the mother’s health.

Objectives:

List the common infectious organisms associated with the TORCH complex

Describe common abnormalities resulting from the vertical transmission of infection

Understand the risk associated with the stage of infection

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