Are smart people really miserable?

Last night, I was watching television; House M.D. to be specific. The storyline was that really smart guy had been miserable when he was functioning on all mental cylinders, and much happier being dumber.
And it made me wonder how much truth there was to the idea.
Both House and the patient seemed pretty miserable. Then again, House always seems miserable. But to lay it on the doorstep of being geniuses, I am not sure if I like that at all.
Now, I am not a genius myself...I just stroll past the neighborhood (a couple of IQ points short)...but I am not miserable. None of the genius level people I know are miserable. Or at least, not to the best of my knowledge. Then again, none of them are nearly as intelligent as the two characters in this espisode.
So is there a connection between happiness (or misery) and intelligence?