Tweaking Keyboard shortcuts

Emacs' shortcuts were designed for an old keyboard, where the alt and ctrl keys were at a different place from today ! My advice is you should take some time to modify the most used to your liking.

Make Caps Lock another Ctrl

that can be done with your desktop manager and it will save your left little finger.

Tweaking default functions' behaviour

Some actions triggered by a key may be incomplete. For example, when I press Enter, I'd like it to go to the next line AND to indent (that saves me a TAB press, and a lot each day). Do you like to type C-a C-k C-k to erase a line ?

Extensions

Keychord mode

Keychord gives the ability to map pairs of simultaneously pressed keys to commands. So you can define some keyboard shortcuts that do not involve Ctrl or Meta.
(In this package, a "key chord" is two keys pressed simultaneously, or a single key quickly pressed twice (excluding Ctrl, Shift or Meta)).

Be careful, do not map two keys that usely go together, or it will be very inconvenient.

Installation

In Emacs 24, it is included in ELPA (or Marmelade repo ?), so :

M-x list-packages

then search for keychord, press 'i' to mark for installation and then 'x' to execute chosen actions.

Choosing an appropriate keyboard

TypeMatrix

The TypeMatrx keyboard is thin, small, has its keys disposed as a matrix and, most of all, it has the Enter and the Backspace keys on the middle, so that you access them with your «second finger» of both hands. As a result, you stop moving your right wrist on a «big» distance to the right. This is known to be life saving (and my experience said that I can't work without a TypeMatrix).

Choosing a different keyboard layout

The Dvorak layout or the french version bépo are good choices. Take some weeks to learn them. You can use two configurations at the same time, it is like learning languages. I love bépo.