The drug, from a company called Rigel, is R788 or fostamatinib disodium. The oral drug targets an enzyme called Syk. Nobody is exactly sure of the role Syk plays in rheumatoid arthritis. But there's an overabundance of Syk in the fluid of arthritic joints, and the enzyme is part of the runaway immune machinery that increases joint inflammation.

Experimental Drug Fights RA

In a pilot study, the drug appeared to reduce symptoms of rheumatoid arthritis. Now Harvard researcher Michael E. Weinblatt, MD, reports results from a phase II clinical trial in which 457 patients with active rheumatoid arthritis despite methotrexate treatment received R788 or placebo for six months.

For patients treated with the more active twice-daily dose of 100 milligrams of R788:

67% had at least 20% fewer arthritis symptoms, compared to 35% of patients getting a placebo.

It's not clear whether long-term use of R788 will increase cancer risk; longer-term clinical trials will have to evaluate this risk.

For now, R788 looks very promising, the researchers report.

"Inhibition of the Syk pathway offers a new drug target for rheumatoid arthritis," Weinblatt and colleagues conclude.

The Weinblatt study and an editorial by NIH researchers Juan Rivera, PhD, and Robert A. Colbert, MD, PhD, appear in the Sept. 30 issue of the New England Journal of Medicine. Rigel funded the study, and three of the study's six authors are Rigel employees. Weinblatt reports receiving grants, fees, or honoraria from a number of drug and biomedical companies, including Rigel.