Increase in celiac disease baffles doctors

ROCHESTER, Minn., July 1 (UPI) -- Celiac disease, an immune system reaction to gluten in the diet, is more than four times more common today than it was 50 years ago, U.S. researchers say.

Dr. Joseph Murray of Mayo Clinic in Rochester, Minn., also found that subjects who did not know they had celiac disease were nearly four times more likely than celiac-free subjects to have died during the 45 years of follow-up.

"Celiac disease has become much more common in the last 50 years, and we don't know why," Murray said in a statement. "It now affects about one in a hundred people."

In patients with celiac disease, the presence of the protein gluten from wheat, barley or rye triggers an immune system attack, damaging the villi in the small intestine. Villi are fingerlike projections that increase the intestine's surface area for nutrient absorption, Murray said.

The researchers tested blood samples gathered at Warren Air Force Base in Wyoming between 1948 and 1954 for the antibody that people with celiac disease produce in reaction to gluten. The study, published in the journal Gastroenterology, found young people today are 4.5 times more likely to have celiac disease than young people were in the 1950s.

"Something has changed in our environment to make it much more common," Murray said. "Until recently, the standard approach to finding celiac disease has been to wait for people to complain of symptoms and to come to the doctor for investigation."

United Press International is a leading provider of news, photos and information to millions of readers around the globe via UPI.com and its licensing services.

With a history of reliable reporting dating back to 1907, today's UPI is a credible source for the most important stories of the day, continually updated - a one-stop site for U.S. and world news, as well as entertainment, trends, science, health and stunning photography. UPI also provides insightful reports on key topics of geopolitical importance, including energy and security.

A Spanish version of the site reaches millions of readers in Latin America and beyond.

UPI was founded in 1907 by E.W. Scripps as the United Press (UP). It became known as UPI after a merger with the International News Service in 1958, which was founded in 1909 by William Randolph Hearst. Today, UPI is owned by News World Communications.