Summaries for ARHGEF16 Gene

Entrez Gene Summary for ARHGEF16 Gene

Although the specific function of this protein is not known yet, it is thought to be involved in protein-protein and protein-lipid interactions. [provided by RefSeq, Jul 2008]

GeneCards Summary for ARHGEF16 Gene

ARHGEF16 (Rho Guanine Nucleotide Exchange Factor 16) is a Protein Coding gene.
Diseases associated with ARHGEF16 include Frontal Sinusitis.
Among its related pathways are GPCR Pathway and Phospholipase-C Pathway.
GO annotations related to this gene include PDZ domain binding and receptor tyrosine kinase binding.
An important paralog of this gene is ARHGEF26.

UniProtKB/Swiss-Prot for ARHGEF16 Gene

Guanyl-nucleotide exchange factor of the RHOG GTPase stimulating the exchange of RHOG-associated GDP for GTP. May play a role in chemotactic cell migration by mediating the activation of RAC1 by EPHA2. May also activate CDC42 and mediate activation of CDC42 by the viral protein HPV16 E6.

Function for ARHGEF16 Gene

Products:

Molecular function for ARHGEF16 Gene

UniProtKB/Swiss-Prot Function:

Guanyl-nucleotide exchange factor of the RHOG GTPase stimulating the exchange of RHOG-associated GDP for GTP. May play a role in chemotactic cell migration by mediating the activation of RAC1 by EPHA2. May also activate CDC42 and mediate activation of CDC42 by the viral protein HPV16 E6.