68 sequences have encircled the globe as of 2010-01-18 * with high fidelity carrying a cross-segmentpaired set of background markers matching and potentially contributing to the Ukraine fatal cases. Kyiv377 from early November in the Ukraine demonstrates a level of hyper-morphic behaviour at amino acid 225 that is previously undocumented in ΣPF11, but is the natural progression of the genetic acquisition trend line on this pandemic reservoir. Two sequences now additionally demonstrate the TamiFlu Resistant 275Y on NA, one from Spain in late November 2009 and one from the US with details stored in a private database.

Moldova, a neighbor of the Ukraine, demonstrates extensive NAsyn407V, but is missing the HA area for the syn413K on most sequences. 5 of 7 from Moldova with complete HA sequences display the cross segment linkage.

Expect to see many sequences from the Ukraine on this particular background when HA and NA are deposited for review as most of the recent published Hemagglutinins do carry the syn413K and the published Neuraminidase match the syn407V. Chernihiv452 from the Ukraine with a mixture of 225D, 225G, 225N and 225S carries the syn413K, but has no NA published. A more comprehensive deposit of these two antigenic gene segments (HA and NA) from the Ukraine would allow a definitive conclusion.

Publication of the remaining Neuraminidase segments for the 33 Norwegian and Japanese specimens bearing HAsyn413K would allow a more precise review. Although 9 of the recent sequences from Norway carry syn413K, none of the 225E strains from Norway have the syn413K. The patterns are highly suggestive that all of the Norse 225G strains do. The 2009-12-29 release of the NA for Norway2924 confirmed that previous suggestion.

The Orenburg2974 sequence from Russia also carries 225N on this background. Bryansk2971, also from Russia with presumably fatal 225G from the lung, demonstrates the syn413K but has no entry for the Neuraminidase to confirm this cross segment linkage.

If RBS revisions at amino acid 225 are, in fact, instructive of high pathogenicity, then Russia is in the FlightPath for a more virulent winter and the Ukraine has presently built a fog of miasma that appears to be capable of spreading across the globe.

Please visit GeneWurx.com for insight into the latest published studies.

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The information in this column is intended for educational purposes only and does not constitute medical advice or individual recommendations by the author. Please work in conjunction with a team of trusted and informed health professionals before making health or lifestyle modifications.

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The information in this column is intended for educational purposes only and does not constitute medical advice or individual recommendations by the author. Please work in conjunction with a team of trusted and informed health professionals before making health or lifestyle modifications.
NS1 studies zoonotic viral genetics.