In the data manipulation realms – like big data / machine learning, or in the genetic realm’s FASTA files – huge files can be used.

For example: In genetic FASTA files, this site from 7 years ago indicates that the number of bytes of the FASTA file are roughly the same as the number of base pairs; genome.gov says that the human genome is about 3 billion base pairs (so about 3Gb). Per Science magazine, there’s a flower than has 149 billion base pairs, which would be on the order of 150GB in the FASTA text format.

but vim 8.x will take a very, very, very long time, if you try to open a 12gb (12288mb) file on any platform (mac, ubuntu and windows) as it will try to load the entire document first, and only stop when a certain memory limit is reached.
(8.1.1 will crash on occasions on huge files)