GenAge entry for FOXO4 (Homo sapiens)

Gene name (HAGRID: 183)

Potential relevance to the human ageing process

Main reason for selection

Entry selected based on evidence directly linking the gene product to ageing in a non-mammalian animal model

Description

A member of the forkhead family, FOXO4 plays a role in development [802] and in insulin (INS) signalling. In roundworms, a homologue of FOXO4, daf-16, has been associated with ageing [628], and overexpression of another homologue, dFOXO, in adult fat body of fruit flies increased longevity in females [1238]. FOXO4's role in human ageing has not been determined.