EXP-1: ROS1 TKI-naïve ROS1+ NSCLC. Up to one prior line of chemotherapy OR immunotherapy
is allowed

EXP-2: 1 Prior ROS1 TKI ROS1+ NSCLC. Disease progression, unresponsive, or intolerant to
one prior line of a ROS1 TKI. Up to one prior line of chemotherapy OR immunotherapy
before or after a ROS1 TKI is allowed

EXP-3: 2 Prior ROS1 TKIs ROS1+ NSCLC. Disease progression, unresponsive, or intolerant
to 2 prior lines of a ROS1 TKI treatment. Up to one prior line of chemotherapy OR
immunotherapy pre-TKI or post-TKI is allowed

EXP-4: ROS1 or ALK TKI-naïve ROS1+ or ALK+ solid tumours (non-NSCLC). No prior ROS1 or
ALK TKIs allowed. Up to 2 prior lines of chemo or immunotherapy are allowed

EXP-5: TRK TKI-naïve NTRK+ solid tumours. Any number of prior lines of chemo or
immunotherapy is allowed.

EXP-6: TRK TKI-pretreated NTRK+ solid tumours. Disease progression, unresponsive, or
intolerant to 1 or 2 prior TRK TKIs. Any number of prior lines of chemo- or
immunotherapy are allowed.