Elucidating the Contribution and Therapeutic Potential of NLRX1 Signaling in Histiocytic Sarcoma
Pilot Grant, (PI: Allen; Co-I: Dervisis; Co-I: Coutermarsh-Ott), 07/01/15 – 06/30/16
VT-MD Regional College of Veterinary Medicine - IRC
This proposal seeks to evaluate the contribution of NLRX1 in the development of the rare cancer histiocytic
sarcoma in mouse and canine models. Specifically, this proposal will elucidate the role of NLRX1 in
modulating AKT and NF-kB signaling in disease.

Novel vaccine system against viral infections
Seed Grant, (Co-PI: Allen; Co-PI: Zhang), 07/01/15 – 06/30/17
Virginia Tech and the University of Maryland CVM Joint Seed Grant
The objective of this study is to explore the vp13 enhancer in Hepatitis E virus for vaccine development based on a partial product of the viral ORF2 and the FcRn-mediated IgG transfer pathway.

NLR Regulation of Gastrointestinal Inflammation and Tumorigenesis
4-K01-DK092355, (PI: Allen), 07/01/11 – 06/30/16
National Institutes of Health - NIDDK
This proposal aims to study the contribution of the NLRP1 and NLRP3 inflammasomes and the anti-inflammatory NLR NLRP12 in colitis and colitis associated tumorigenesis.