A novel electronic halocyclization and radical haloazidation of benzene-linked 1,7-dienes for the formation of functionalized 3,1-benzoxazines has been achieved by using TMSN3 as an azido source and NBS as a...

The behavior of phosphinyl nitrosoalkenes with indole, pyrrole and 2,5-dimethylpyrrole is described. The reaction of nitrosoalkenes with indole leads to the formation of 3-substituted indoles. While a concerted asynchronous [4+2]...

The synthesis of sialic acids and their analogs was accomplished based on substrate-controlled asymmetric aldol reactions between sterically complicated aldehydes easily prepared from commercially available carbohydrates and a novel pyruvic...

A diastereoselective approach to trans-4-hydroxy-5-substituted 2-pyrrolidinones 1 (P1=TBS, P2=H) has been developed through stereoselective tandem Barbier process of (R,SRS)-8 with alkyl and aryl bromide. The stereochemistry at the C-5 stereogenic...

The proline analogue (2S,3aS,7aS)-octahydroindole-2-carboxylic acid (Oic) has been previously applied as a proline substitute in pharmocologically active peptides and as a structural component of the antihypertensive drug Perindopril. Herein, we...

A new chiral chromane receptor has been synthesized with a right-sized oxyanion hole to fix zwitterionic alanine. This associate allows the enantioselective extraction of this amino acid from water to chloroform.

Overwound and underwound paranemic crossover (PX) DNA motifs have been self-assembled to generate high uniformity lattices, by adjusting the number of base pairs in the JX region adjacent to the PX structure to relieve torsional strain.

para-Nitrophenyl α2–8-sialosides containing different sialic acid forms were chemoenzymatically synthesized and used as effective probes for high-throughput substrate specificity studies of the α2–8-sialidase activities of human and bacterial sialidases.

The typically planar amide when incorporated in bicyclic systems can undergo a significant distortion from planarity resulting in physical properties and reactivity that deviate from classical amide behaviour. Herein, we...

This review article covers the main types of gold(i) complexes used as precatalysts under homogeneous conditions in organic synthesis and discusses the different ways of catalyst activation as well as ligand, silver, and anion effects.