In the beginning, DHC's programming schedule comprised material from other Discovery Communications entities, most notably medical-based reality show programming from TLC. As the network matured, it began producing its own programming in the reality show genre, mostly dealing with babies (Babies: Special Delivery, Birth Day), bodies (Plastic Surgery: Before and After, National Body Challenge), and medicine (The Critical Hour, Dr. G: Medical Examiner). DHC also showed episodes of the CBS medical drama series Chicago Hope on a semi-regular basis. DHC also aired fitness-related programming, most of which later spun off to its sister network FitTV.

DHC won its first Daytime Emmy in 2004 for its original series about adoptive families, Adoption Stories.

In November 2009, it was announced that Discovery Health Channel would become defunct and be replaced with a new network, OWN: Oprah Winfrey Network, at 12:00 am Eastern/Pacific (11:00 pm Central) on January 1, 2011.[1][2][3]

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Discovery Health was discontinued at 11:59 pm Eastern/Pacific (10:59 pm Central) on December 31, 2010. A minute later, it was replaced by a new lifestyle network headed by television personality Oprah Winfrey, known as OWN: Oprah Winfrey Network.[1][2][3]

On January 1, 2011, most of the programming that had been airing on Discovery Health Channel moved to FitTV. A few Discovery Health Channel shows were picked up by OWN: Oprah Winfrey Network. A month later, FitTV would be rebranded as Discovery Fit & Health.