Coq10

In a study involving human SH-SY5Y neuronal cells with 1mM para-aminobenzoic acid (PABA) which induced a 54% decrease in cellular coenzyme Q10 status, treatment with 2.5 microM coenzyme Q10 for a period of 5 days significantly decreased the level of mitochondrial superoxide in the coenzyme Q10 deficient neurons, and 5 microM of coenzyme Q10 restored mitochondrial membrane potential to 90% of the control levels, while 10 microM coQ10 was only partially effective at restoring mitochondrial electron transport chain (ETC) enzyme activities.

In a study involving a cohort of healthy, community-dwelling elderly people who were divided according to gender and fitness, people with higher levels of functional capacity were found to have lower levels of cholesterol and lipid peroxidation, accompanied with higher levels of coenzyme Q10 in plasma, and the ratio of coenzyme Q10/cholesterol and coenzyme Q10/LDL increased in these people as well.

In a study involving sickle cell patients in the Chhattisgarh tribal population between the ages of 10 and 55 years of age, supplementation with coenzyme Q10 (200 mg/d) was found to improve hematological parameters and decrease inflammation (C-reactive protein) and TBARS levels.

It’s well established that Coenzyme Q10 (CoQ10) is beneficial for maintaining a healthy heart and protecting the brain, but a new study indicates CoQ10 may be an untapped aid for those with chronic depression.

No matter whom you are, your heart beats about 100,000 times a day, fueling your entire cardiovascular system. When coenzyme Q10 (CoQ10) levels get depleted, your heart strains to get its job done and your entire body suffers. This manifests and results in what seem to be “mysterious symptoms” that most allopathic doctors just can’t put their finger on, so they put a “prescription” on it instead. Are you experiencing chronic fatigue, numbing dull pains or decreases in mental functions? This is not just about smokers and the elderly, as this addresses every human being whose heart beats one million times in ten days. It’s time to consider natural solutions to seemingly “complex problems.”

In this review, the authors analyze the effects of coenzyme Q10 supplementation on myopathy induced by the use of statin drugs. Results found a significant relationship between statin intake and decreased serum levels of coenzyme Q10, a reduction in symptoms of myalgia (in a few studies) and an improvement in serum coenzyme Q10 levels.

We’ve long known that CoenzymeQ10, also known as CoQ10, is critical for heart health, but here’s an exciting new reason to consider taking it: CoQ10 may actually help protect your brain from Alzheimer’s. The potent antioxidant attenuates the type brain damage that leads to Alzheimer’s disease, say researchers at Hanyang University College of Medicine, who tested CoQ10 on animals with Alzheimer’s-type brain damage.

High oxidative stress and chronic inflammation can contribute to the pathogenesis of coronary artery disease (CAD). Coenzyme Q10 is an endogenous lipid-soluble antioxidant. Statins therapy can reduce the biosynthesis of coenzyme Q10. The purpose of this study was to investigate the effects of a coenzyme Q10 supplement (300 mg/d; 150 mg/b.i.d) on antioxidation and anti-inflammation in patients who have CAD during statins therapy.

In a study involving four patients with fibromyalgia, all of whom were found to have a deficiency of coenzyme Q10, oral supplementation with coenzyme Q10 was found to be associated with important improvements in clinical symptoms, based on all evaluation methods used (American College of Rheumatology Diagnostic Criteria of 1990 and 2010, and the Symptom Checklist-Revised (Scl-90-R).

Although there are hundreds of naturally occurring antioxidants, five in particular work together in a unique relationship to support and strengthen the entire antioxidant system. These antioxidants, called network antioxidants, include lipoic acid, vitamins C and E, CoQ10 and, the mother of all antioxidants, glutathione.