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Titles should be concise, specific, and informative and should contain the key points of the work. For scientific manuscripts, overly general titles are not desirable (but see also , Names of Cities, Counties, States, Provinces, and Countries). (Note: The shorter, more general title might be appropriate for an editorial or an opinion piece.) Similarly, although the subtitle is frequently useful in expanding on the title, it should not contain key elements of the study as a supplement to an overly general title. However, too much detail also should be avoided. Subtitles should complement the title by providing supplementary information that

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