In Melty Blood Act Cadenza, almost all events that occur in the story-modes of the characters in this game are set in events based on alternate realities and different timelines that are totally out of current chronological timeline of Tsukihime/Melty Blood series (except certain story-modes of some characters).

The story-modes of the characters in this game are basically events that occurred as if certain characters act as if they appeared for the first time in Misaki Town (Arcueid Brunestud, Ciel, Sion Eltnam Atlasia, Sion TATARI, Nrvnqsr Chaos and Night of Wallachia) and knew the inhabitants of this city in their story-modes, while other characters act as if they knew certain characters for the first time or to solve a mystery that is causing a supernatural disturbance which is disturbing the people of Misaki town (Shiki Tohno, Akiha Tohno, Hisui, Kohaku, Hisui & Kohaku, Aoko Aozaki, Satsuki Yumizuka and Len).

There are those that are causing problems, and these enemies were generated and materialized by TATARI phenomenon caused by Wallachia, like if the first time they appeared in Misaki Town to terrorize the population (Shiki Nanaya, Red Arcueid and Kouma Kishima), and there are also those that appear during the confusion caused by TATARI phenomenon this same alternate reality, only to pursue their own personal goals (Akiha Vermilion and Mech-Hisui).

And finally have certain characters whose events occurred within of the official chronological timeline of Tsukihime/Melty Blood series, where these small events occurred some time after the events in Melty Blood Re-ACT (Miyako Arima, Neco-Arc, White Len and Neco-Arc Chaos), then follow later on in the future when the events of Melty Blood Actress Again/Melty Blood Actress Again Current Code would occur soon.

In short, the game is just a short sequence of events in alternate realities and different timelines with characters from Tsukihime and Melty Blood Series, with numerous possibilities of events that have occurred out of official chronological timeline of Tsukihime/Melty Blood series (except some exceptions), to give time to Kinoko Nasu finished writing the script and the story mode of the true continuation of Melty Blood and Melty Blood Re-ACT, which is the Melty Blood Actress Again/Melty Blood Actress Again Current Code.

As the game was produced by Sega and Ecole to give time to Kinoko Nasu finished the script for the true continuation of Melty Blood Re-ACT, was the Ecole which organized the script and the story-modes of Melty Blood Act Cadenza.