The result of therapy for youth acute myelogenous leukemia (AML) have better significantly over the last ten years. This growth used to be verified via the 2 consecutive multicenter reviews, AML-BFM-78 and -83, during which virtually exact prolonged multi drug regimes of che­ motherapy have been administered for 8 weeks and up via years upkeep. the most distinction within the moment learn was once the addition of an eight-day in depth in­ duction direction. because of this new point, the relapse expense used to be decreased considerably. one other results of the BFM-83 examine was once the definition of 2 hazard teams at the foundation of standardized therapy, which has bring about a risk-adapted remedy procedure within the 3rd ongoing trial, AML-BFM- 87. This development was once simply attainable due to the coop­ eration of pediatricians, physicians, radiotherapists, statisti­ cians, and particularly the employees on the hospitals and reference laboratories. therefore, we wish to thank every person who has been fascinated about those stories and wish that they're going to be additional inspired to enhance remedy innovations for AML in young children. The coordination, enforcement, and analyses of the stud­ ies do not need been attainable with no the monetary sup­ port of the Federal Ministry for study and expertise of the FRG. we're thankful for the beneficiant contributions aiding this publication from Lederle and Farmitalia. Munster, April 1990 Ursula Creutzig Jorg Ritter Gunther Schellong Contents 1 creation . . . . .. . . . . . . . . . . . . . . .. . . . 1 .

R 0 2 3 - - AML-BFM 78 ( N ........... AML-BFM 83 ( N - 4 5 29 31 6 7 B 9 10 YEARS 15 IN CCR ) 23 IN CCR ) Fig. 14. a Probability of EFS duration in patients with FAB Ml in AML-BFM-78 vs. AML-BFM-83. b Same for EFI duration FAB M3. Out of a total of 11 patients with acute promyelocytic leuke- mia, two suffered ED from intracranial hemorrhage, one from ulcer bleeding and one from sepsis. Of the two children who died in CCR, one died after six weeks from the sequelae of anthracycline-induced cardiotoxicity, the other from undetected tuberculosis after eight months.

0.. 2 2 3 - - AML-BFM 78 ( N ........... B .... --~~~,-~~~~,-~~-r 0 2 3 - - AML-BFM 78 ( N ........... AML-BFM 83 ( N - 4 5 29 31 6 7 B 9 10 YEARS 15 IN CCR ) 23 IN CCR ) Fig. 14. a Probability of EFS duration in patients with FAB Ml in AML-BFM-78 vs. AML-BFM-83. b Same for EFI duration FAB M3. Out of a total of 11 patients with acute promyelocytic leuke- mia, two suffered ED from intracranial hemorrhage, one from ulcer bleeding and one from sepsis. Of the two children who died in CCR, one died after six weeks from the sequelae of anthracycline-induced cardiotoxicity, the other from undetected tuberculosis after eight months.