Mr. White was previously a Section 16 filer with respect to Nanosphere Inc. in November 2007 as an indirect 10% owner with respect to his indirect beneficial ownership of shares held by Lurie Investment Fund, L.L.C. As a result of changes to the organizational documents of Lurie Investment Fund, L.L.C., Mr. White ceased to be a beneficial owner of such securities under Rule 13d-3 and subject to Section 16 reporting under Rule 16a-2. This Form 3 is being filed by Mr. White in connection with his election to the board of directors of Nanosphere Inc. on May 30, 2012.

/s/ Roger Moody, Attorney-in-Fact

06/11/2012

** Signature of Reporting Person

Date

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.

* If the form is filed by more than one reporting person,
see
Instruction
5
(b)(v).