The Pipeline Tracker is getting a new look and is currently under construction. Please return back in May 2019 for updates. In the meantime, if there are any updates to the current pipeline tracker, please email Sonya Dumanis.

The mission of the Epilepsy Foundation includes accelerating new therapies for people living with epilepsy and seizures. As a reflection of our commitment and as a service to the community we are pleased to provide here the pipeline of epilepsy therapies in various stages of development. We thank all of the individuals and organizations whose efforts are reflected in these seeds of hope. The Epilepsy Foundation makes no claims of accuracy of the following data. Although every effort is made to continuously update this list, some errors are inevitable. Companies or academicians or others who are directly involved with any of the therapies listed here are strongly encouraged to keep us updated by contacting contactus@efa.org of any needed changes.

Phases

Rather than only use the traditional Phase I,II, and III (which can also be ambiguous), we have chosen more meaningful "break points" for epilepsy therapies:

Phase O

Preclinical — Not Yet In Humans

Phase I

First Clinical Use — The Therapy Has Been Tested In A Small Number of Humans (Usually Non-Patient Volunteers)

Phase IIa:

Early Patient Use — A Few Patients With Seizures Have Been Exposed To The Therapy; Small Clinical Trials Are Underway Or Completed

Phase IIb

Critical Proof of Concept — A Large Trial, Suitable As A Registration Study, Has Shown Positive Results (Devices move directly to Phase III

Phase III

Late Clinical Use — The Therapy Is In The Final Stages Of Acquiring All The Data Needed For Registration; Many Patients Have Received the Therapy

Registration (R)

The Therapy Has Been Accepted for Potential Approval by the FDA (Filing Has Been Accepted)

Approved and To The Patients (US)

The Therapy Is Available To Patients In The US

Approved and To The Patients (ex-US)

The Therapy Is Available To Patients outside of the US

When support has been provided by the Epilepsy Foundation (or the former Epilepsy Therapy Project, which is now an initiative of the Epilepsy Foundation), the therapy is listed under the "Phase" column(s) in a darker blue.

When support has been provided by other sources, the therapy is listed under the "Phase" column(s) in a lighter orange.

Sponsors

When support has been provided by the Epilepsy Foundation or its partners, the organization's abbreviated name is listed under the "Sponsors" column.

Categories

In each of the following categories the therapies are listed in alphabetical order, and when available, are linked to more information. The company name or institution associated with each therapy is also provided.