flame sensor technology and Inline
Matrix Elimination has become
the method of choice for these
determinations.

Another CIC application
cited by Metrohm combines
pyrohydrolytic sample combustion
and absorption of the evolving combustion
gases in an oxidizing aqueous solution
that is then fed into an IC for analysis
of halides and sulfur (as sulfates).
The combustion and analysis of certified reference materials (CRMs) proves the reliability of the CIC methodologies.

HPIC systems

A little over a year ago at Pittcon 2012, researchers
at Thermo Fisher Scientific introduced the Thermo
Scientific Dionex (TSD) ICS-4000 and ICS-5000
instruments, claimed as the world's first commercially available integrated capillary high-pressure ion
chromatography (HPIC) systems. One of these instru-ments' main features was the integration of multiple
detector options in one unit, which included a conductivity detector, an electrochemical detector and a
Dionex charge detector.

Those releases were followed up in October 2012
with the release of the TSD ICS-5000+, a new HPIC
system with increased resolution and speed. When used with
unique 4 µm particle-size IC columns, the system is ideally suited for high-resolution and high-throughput separations. The ICS-5000+ HPIC system
enables users to discover peaks that may have been missing with lower-pressure systems. As with previous Dionex IC systems, the ICS-5000+ is a
reagent-free instrument that uses deionized water to electrolytically generate
high-purity eluents, with its Eluent Generator module (EG). This module,
RFIC-EG, is available in a number of capillary and analytical cartridges
versions. The EG module can help save time and operating costs, enhance
reproducibility, minimize labor and limit contamination.

The ICS-5000+ system is designed for a broad range of applications in
environmental, chemical, food safety, pharmaceutical, biopharmaceutical

ABOVE: Combustion IC is ideal for routineanalysis in a variety of fields, including envi-ronmental, petrochemical, pharmaceu-tical and more. FAR LEFT: The DionexERS 500 Electrolytically RegeneratedSuppressor serves virtually all ana-lytical-scale IC applications for bothanions and cations. LEFT: Developedwith flexibility, modularity and ease-of-use in mind, the Dionex ICS-5000+HPIC system combines high sensitiv-ity with convenience.

and other life science industries. The
ICS-5000+ also supports a wide range
of detectors, including suppressed and
non-suppressed conductivity, electrochemical, UV-Vis and mass spectrometry. For simultaneous analyses of two
samples or two-dimensional analyses
of a single sample, the system includes
two channels that can be configured in
a variety of ways, including standard
bore/microbore, capillary/capillary and
standard bore/capillary formats.

Electrolytically Regenerated Suppressor, which replaces the SRS 300 Self-Regenerating Suppressor. The Dionex SRS 500 minimizes dispersion to deliver
higher resolution separations, especially when coupled with 4 µm-based
IC columns. The suppressor permits improved compatibility with a wider
range of detection techniques including MS, ICP and ICP-MS because of its
improved backpressure resilience. Additionally, the new suppressor precludes
the need for periodic chemical regeneration, allowing for greater ease-of-use
and reproducibility. The ERS 500 also has a new hardware design that allows
the suppressor to be more pressure tolerant than previous generation suppressor devices. The suppressor flow path has been redesigned to optimize band
dispersion and improve the flow and sealing properties.