Andrew Stone was born in a farming commune in Iowa on 18 January2025, isolated from industrial life. The appalling storm conditions of 2040 forced the commune to adapt their way of life and develop revolutionary ways of growing food in bad weather. In 2045, Andy left the commune to bring this knowledge to the rest of the world, which was racked by climate change. His research on crop growth in hostile environments was picked up by Mia Bennett and her father, and he joined their research team. Andy was encouraged by Mia's father to join NASA, despite his lack of formal qualifications.

In 2059, he was the first of the Bowie Base One colonists to be infected by the Flood, through consuming a carrot washed with the base's contaminated water supply. He infected Maggie Cain and Tarak Ital. When the Tenth Doctor and Adelaide Brooke reviewed the maintenance log reports, they discovered an entry by Andy stating that the water filter had broken and that the replacements wouldn't fit, allowing the infection to spread through the base's water supply. The infected form of Andy was destroyed when Adelaide Brooke activated Action Five, blowing up the base. (TV: The Waters of Mars)