Launches of Zenit-2M rockets are conducted from Baikonur CosmodromeSite 45/1. Commercial launches are conducted by Land Launch, and use the designation 2SLB, however as of 2011, no commercial launches have been ordered. Launches conducted by Roskosmos or the Russian Space Forces use the designation 2M. The designation 2SB can also be applied to the rocket when it is being used as part of a larger vehicle, such as the Zenit-3SLB.

The first launch of a Zenit-2M occurred on 29 June 2007, carrying the last Tselina-2ELINT satellite for the Russian Space Forces, Tselina-2 satellites having been previously launched by older Zenit-2 rockets. The second launch, carrying the Fobos-Grunt and Yinghuo-1 spacecraft, was conducted on 8 November 2011, using a modified configuration also designated the Zenit-2FG. This configuration incorporated the payload fairing used on the Zenit-3F rocket, and a special adaptor for the Fobos-Grunt spacecraft, which incorporated a Fregat-derived propulsion system.