Engagement of the IFN-alphabeta receptor initiates multiple signaling cascades, including activation of the STAT. In this study, we demonstrate that IFN-alphabeta, although antiproliferative in… (More)

Type I interferon (IFN)-alpha/beta and type II IFN-gamma induce the expression of early response genes through activation of the Janus tyrosine kinase/signal transducer and activator of transcription… (More)

STAT1 is an essential part of interferon signaling, and STAT1-deficiency results in heightened susceptibility to infections or autoimmunity in both mice and humans. Here we report that mice lacking… (More)

The growth-inhibitory effects of type 1 interferons (IFNs) (IFNalpha/beta) are complex, and the role of apoptosis in their antigrowth effects is variable and not well understood. We have examined… (More)

Engagement of the IFNreceptor initiates multiple signaling cascades, including activation of the STAT. In this study, we demonstrate that IFN, although antiproliferative in wild-type CD4 or CD8 T… (More)

Based on the hypothesis that 26 kD membrane-bound rumor necrosis factor precursor (proTNF) may act as a principle regulator to maintain homeostasis in an adult, we tried to examine whether proTNF… (More)

Eosinophilic bronchitis is an essential component of bronchial asthma, and eosinophils play an important role. We studied the effect of eosinophils on cell surface plasmin generation by bronchial… (More)