@Article{Mirzaei-Alavijeh2016,
author="Mirzaei-Alavijeh, Mehdi
and Hidarnia, Alireza
and Kok, Gerjo
and Niknami, Shamsaddin
and Motlagh, Mohammad Ismail",
title="The ‘my family-study’ onset substance use prevention programme in early childhood: an introduction",
journal="Arvand Journal of Health and Medical Sciences",
year="2016",
volume="1",
number="3",
pages="-",
abstract="Prevalence rate of substance abuse is increasing in Iran (1) and there is a decrease in the age the onset of substance use (2). Therefore, it seems necessary to preventing substance abuse since early childhood. Since family play an essential role in development and growth of children among genetics, temperament and environment factors (3, 4), and studies have shown family can protect children against substance abuse behaviors (5-7), and family has been known as one of the most important preventive factors (8, 9),",
issn="2476-6275",
doi="10.22631/ajhms.2016.43197",
url="http://arvandj.abadanums.ac.ir/article_43197.html"
}
@Article{Rostami2016,
author="Rostami, Amin
and Goshadrou, Fatemeh
and Ahmadian, Gholamreza",
title="Immobilization of alpha toxin on the surface of the bacillus subtilis spores",
journal="Arvand Journal of Health and Medical Sciences",
year="2016",
volume="1",
number="3",
pages="-",
abstract="All strains of Clostridium Perfringens have gene encoding alpha toxin. Alpha toxin is important in pathogenesis of several diseases from gas gangrene to necrotic enteritis in chickens. The toxin is consists of two domains, the N-domain containing the site for phospholipid hydrolysis and the C-domain plays a role in haemolytic and sphingomyelinase activities. The presence of the C-domain is crucial for recognition of the cell membrane phospholipids by the toxin. It is shown that Immunization against the C-terminal domain of the toxin can make protection, at least partially against diseases like gas gangrene.On the other hand, Bacillus subtilis spores are known to be GRAS, highly resistant to harsh conditions and inducing protective immune response. These attributes make Bacillus subtilis spores an ideal candidate for drug and vaccine delivery.At the present study, as a preliminary step toward developing an effective vaccine against necrotic enteritis, the immunogenic region of alpha toxin is cloned, expressed and purified. The purified region was then covalently immobilized on the surface of the Bacillus subtilis spores, using non-genetically approach. The presence of alpha toxin on the spore surface is then verified by western blotting[L1] . [L1]Please add at least one line conclusion here.",
issn="2476-6275",
doi="10.22631/ajhms.2016.43198",
url="http://arvandj.abadanums.ac.ir/article_43198.html"
}
@Article{Alavian2016,
author="Alavian, Seyed Moayed
and Farahi, Rashin",
title="Arvand free zone region can be pioneer in health tourism related to liver diseases",
journal="Arvand Journal of Health and Medical Sciences",
year="2016",
volume="1",
number="3",
pages="-",
abstract="Iran has progressed significantly in control and treatment of patients with hepatitis B virus (HBV) and hepatitis C virus (HCV) infections during recent 25 years. The view of the issue in the region mandate us to work more for medical tourism. I will present the data about our opportunity to have more people from our neighbors such as Iraq and Kuwait for medical purposes in field of hepatology here.",
issn="2476-6275",
doi="10.22631/ajhms.2016.43199",
url="http://arvandj.abadanums.ac.ir/article_43199.html"
}
@Article{Ghasiyari2016,
author="Ghasiyari, Haniye
and Rostami Nejad, Mohammad
and Amani, Davar
and Amani, Davar
and Zali, Mohammad Reza
and Zali, Mohammad Reza",
title="Crucial role of innate immune system in the pathogenesis of celiac disease",
journal="Arvand Journal of Health and Medical Sciences",
year="2016",
volume="1",
number="3",
pages="-",
abstract="Celiac disease (CD) is a chronic autoimmune disorder caused by ingestion of gluten peptides in genetically predisposed individuals. In susceptible individuals, immune response to gluten results in intestinal damage and a wide range of clinical manifestations. Although both of innate and adaptive immunity is importance for response to gluten but innate system play a critical role in initiation of this process. Thus the main objective of this review is to investigate the role of innate immune system in the pathogenesis of celiac disease.",
issn="2476-6275",
doi="10.22631/ajhms.2016.43200",
url="http://arvandj.abadanums.ac.ir/article_43200.html"
}
@Article{Azizi2016,
author="Azizi, Razieh
and Karimi-Arzenani, Mohsen
and Tabrizi, Mina
and Talebi, Saeed
and Akrami, Seyed Mohammad",
title="Aberrant methylation detection of the hMLH1 promoter and the IGF2 DMR region using methylation-sensitive high resolution melting (MS-HRM) in colorectal cancer",
journal="Arvand Journal of Health and Medical Sciences",
year="2016",
volume="1",
number="3",
pages="-",
abstract="Epigenetic alterations and gene mutations causing inactivation of tumor suppressor genes and activation of oncogenes can regulate signaling pathways contributing to colon cancer formation. Many genes have been reported to be aberrantly methylated in the CRC genome, and it is likely that only subsets of these genes are important in the pathogenesis of colorectal tumors. We applied the methylation-specific high resolution melting (MS-HRM) technique to study methylation of the IGF2 DMR and the hMLH1 gene promoter in 60 colorectal cancer and adjacent normal tissues of same patients compare to 20 normal tissue samples. In this study, 5 of the 60 colorectal cancer samples (8.3%) were found to be methylated at the hMLH1 promoter region and 32 of the 60 colorectal cancer samples (53.3%) were found to be hypomethylated at the IGF2 DMR region. Adjacent normal tissues were unmethylated for hMLH1 and 5% showed hypomethylation for IGF2 DMR. There was significant correlation between aberrant methylation of hMLH1 and IGF2 DMR with tumor location (p=0.002, p=0.026 respectively). In addition, a tendency of association between IGF2 DMR hypomethylation and age (p=0.06) was observed. We demonstrated effectiveness of the MS-HRM technique to analyze methylation of IGF2 DMR and hMLH1 promoter region and methylation significantly correlated with tumor location in colorectal cancer patients.",
issn="2476-6275",
doi="10.22631/ajhms.2016.43201",
url="http://arvandj.abadanums.ac.ir/article_43201.html"
}
@Article{Jalilian2016,
author="Jalilian, Farzad
and Mirzaei-Alavijeh, Mehdi
and Karami Matin, Behzad
and Mahboubi, Mohammad
and Firoozabadi, Abbas",
title="Understanding mammography behavior among the west of Iranian women: stage of change model testing",
journal="Arvand Journal of Health and Medical Sciences",
year="2016",
volume="1",
number="3",
pages="-",
abstract="Breast cancer is the second leading cause of death in industrial countries and the third one in developing countries. The aim of this study was determined the stages of change of mammography screening behavior among women. This cross-sectional study was conducted on 400 women aged 30 to 60 years old referred to health centers in Kermanshah County, the west of Iran, during 2016, who were randomly selected to participate in the study. Data collected by standard questioner and were analyzed by SPSS version 21. The mean age of respondents was 39.61 years [SD: 8.28]. Our findings indicated, nearly 59 % (236/400), 27.3 % (109/400), 2.5 % (10/400), 9.3 % (37/400), and 1.8 % (7/400) of the respondents reported that pre-contemplation, contemplation, preparation, action, and maintenance, respectively. Our results showed most of the women were in pre-contemplation and contemplation stages regarding doing mammography. These results can be highly useful to the researchers in designing effective interventional plans for achieving the intended objectives.",
issn="2476-6275",
doi="10.22631/ajhms.2016.43202",
url="http://arvandj.abadanums.ac.ir/article_43202.html"
}
@Article{Mansouri2016,
author="Mansouri, Vahid
and Vafaee, Reza
and Abaszadeh, Hojatollah
and Heidari, Mohammadhossein",
title="Protein-protein interaction network analysis of obesity",
journal="Arvand Journal of Health and Medical Sciences",
year="2016",
volume="1",
number="3",
pages="-",
abstract="Obesity is a multifactorial disease that its molecular bases are very complex. Due to its complexity, there is no efficient medication for obesity. In this paper, protein analysis based on protein–protein interaction (PPI) network is illustrated and discussed in details to better understand obesity-underlying mechanism. The number of 45 proteins that their expressions are changed in obesity is interacted by Cytoscape Software and the hub and bottleneck proteins are introduced. The findings showed that UBC, AKT1, and T53 are hub-bottlenecks in the obesity network as their centrality are the highest. The enrichment analysis identified biological processes that possibly are important in obesity. It can be concluded that central elements of the network may play important role in obesity mechanism; however, further researches are required.",
issn="2476-6275",
doi="10.22631/ajhms.2016.43203",
url="http://arvandj.abadanums.ac.ir/article_43203.html"
}
@Article{Jamalan2016,
author="Jamalan, Mostafa
and Zeinali, Majid
and Amin, Mansour",
title="Computational design of a new inhibitor for 6-Hydroxymethyl-7,8-dihydropteroate synthase from Mycobacterium tuberculosis",
journal="Arvand Journal of Health and Medical Sciences",
year="2016",
volume="1",
number="3",
pages="-",
abstract="Tuberculosis that is caused by Mycobacterium tuberculosis is one of the widespread infectious diseases with millions of death worldwide. Prevalence of Multi-drug-resistant (MDR) tuberculosis and emergence of extensively drug-resistant (XDR) species of M. tuberculosis have necessitated the discovery of new and potent antibiotics. Designing of specific inhibitors for 6-hydroxymethyl-7,8-dihydropteroate synthase (DHPS) has attracted a great interest because of its crucial role in de novo folate synthesis in prokaryotic but not in mammalian cells. In the current study, the ligand of DHPS, namely 6-hydroxymethylpterin monophosphate (PtP) was used as a template for structural-based inhibitor design. Virtual screening was performed between compounds with structural similarity to PtP. Between docked compounds against DHPS, 2-amino-6-(1,2,3-trihydroxybutyl)-1H-pteridin-4-one (PtP_1) showed the most negative free energy of binding. Binding of PtP and PtP_1 to DHPS was further investigated through molecular dynamic simulation. DHPS as alone or in complex with ligands was minimized, solvated in an explicit water cage, neutralized by addition of required ions and simulated for 50 ns. According to trajectories, PtP_1 shows high affinity for the active site of DHPS by H-bonds, hydrophobic forces, and cation-π interactions. Our results show that there could be a great chance for designing new inhibitors against DHPS from M. tuberculosis.",
issn="2476-6275",
doi="10.22631/ajhms.2016.43204",
url="http://arvandj.abadanums.ac.ir/article_43204.html"
}
@Article{Izadi2016,
author="Izadi, Fereshteh",
title="Identification of key regulators in non-small cell lung cancer based on network topology and modularity analysis",
journal="Arvand Journal of Health and Medical Sciences",
year="2016",
volume="1",
number="3",
pages="-",
abstract="Lung cancer predominantly non-small cell lung cancer is a worldwide leading cause of tumor killer therefore exploring underlying biological networks and modularity analysis will be possibly lead to identifying putative key genes involved in this malignancy and its sub-types. In this study using GENIE3 one of the most prominent gene regulatory network inference algorithms we reconstructed independent gene regulatory networks from normal and lung cancer data following topology analysis. Afterward we attempted to highlight the crucial genes involved adenocarcinoma and squamous sub-types of this cancer by networks modularity analysis. The results lead to detection of 19 critical genes as varied hub and bottleneck genes and further seed and crucial nodes by analysis of extracted sub-networks from first neighborhoods of hubs and bottlenecks. As a result we observed that the detected genes involved in several of biological process toward lung cancer progression. Analysis of non-small cell transcriptional networks showed a potential ability to provide useful information toward gaining more insights in this cancer also its sub-types. ",
issn="2476-6275",
doi="10.22631/ajhms.2016.43205",
url="http://arvandj.abadanums.ac.ir/article_43205.html"
}