Mood Disorder, or Mad Disorder?

June 15, 2007

ESSAY by JAMES POTASH, M.D.

The elderly woman with depression is convinced God is punishing her for having sinned in her youth through sexual improprieties. The middle-aged depressed man believes he deserves to die because he (inaccurately) thinks he has mismanaged his family's finances and will leave them destitute. The young woman with depression hears voices telling her she is no good and should kill herself.

Depression is officially classified as a mood disorder, and, indeed, people with depression typically experience major changes in their mood, often feeling sad, down, numb, empty or hopeless.

But sometimes people with depression go mad, as in crazy, or to use the technical lingo, psychotic.

At one level, this underscores that clinical depression is not the same thing as merely feeling down in response to having had a bad day or a bad week. Rather than merely being the blues that we all have from time to time, depression can involve a break with reality, as when someone experiences hallucinations, such as hearing voices when no one is around or seeing things when nothing is there, or delusions, irrational beliefs of the kind noted above.

These symptoms of madness, these psychotic symptoms, are common in the mood state we call mania, which is the high pole of bipolar disorder, occurring in more than half of this type of disordered mood. But they also occur in a smaller proportion of depressive mood episodes: Most studies say about 15 percent of them.

Singling Out Psychotic Depression

How are these psychotic depressions different from other depressions?
As you may guess, adding psychosis to the picture means even more difficulties for people who are already battling depression; as confirmed by William Coryell, at the University of Iowa, and his colleagues when they studied people with psychotic depression over a period of 10 years.

In a study here at John Hopkins that will soon be published in the journal Bipolar Disorders, my colleagues and I studied 4,724 people with mood disorders to see whether psychotic depression was more common in people with bipolar disorder than in those with depression only.

The depression-only group never had the mild highs or hypomanias characteristic of bipolar disorder, type 2, or the severe highs characteristic of bipolar disorder, type 1.

We observed that people with bipolar disorder, type 1 had about a five times higher rate of psychotic symptoms in their depressions than did the other two groups; more than 25 percent of their depressions were psychotic compared with 6 percent for bipolar disorder type 2 and for depression only.

What this means is that the more severe form of depression is strongly associated with the most severe type of mood disorder.

Seeking Help

What about the implications for treatment?

Psychotic depression is often treated with both an antidepressant medication and also an antipsychotic medication. The research to date shows that this combination is more effective than using an antipsychotic medication alone -- and although it is probably more effective than an antidepressant alone, this has not been conclusively proved.

Electroconvulsive treatment, sometimes called "shock therapy," is often an effective alternative to medication for these very ill patients. Consideration should also be given to whether the patient has bipolar disorder and might need mood stabilizer medication.