SMYD: SET and MYND domain-containing proteins (SMYD) are a special class of protein lysine methyltransferases involved in methylation of histones and non-histone targets. To date, there are five members from the SMYD family, SMYD1-5. Each member contains a conserved SET (Suppressor of variegation, Enhancer of Zeste, Trithorax) domain that is "split" by a Myeloid-Nervy-DEAF1 (MYND) domain . The SET domain is a conserved catalytic unit for lysine methylation found in nearly all histone methyltransferases (HMT) . The MYND domain is a zinc finger motif that primarily functions as a protein-protein interaction module. (1)