EOGT functions were investigated in retinal angiogenesis that depends on Notch signaling. Global or endothelial cell-specific deletion of Eogt resulted in defective retinal angiogenesis, with a mild phenotype similar to that caused by reduced Notch signaling in retina. [Elife]
Full Article

Biglycan (BGN) has reduced expression in placentae from pregnancies complicated by fetal growth restriction (FGR). Investigators used first trimester placental samples from pregnancies with later small for gestational age infants as a surrogate for FGR. BGN reduction decreased network formation of telomerase-immortalized microvascular endothelial cells but did not affect thrombin generation or cellular proliferation. [Arterioscler Thromb Vasc Biol]
Abstract

High plasma Na+ concentrations (high Na+) have been shown to stiffen the endothelial cortex and decrease nitric oxide release, a hallmark of endothelial dysfunction. Researchers report that chronic high Na+ damaged the endothelial glycocalyx, induced release of inflammatory cytokines from the endothelium and promoted monocyte adhesion. [Sci Rep]
Full Article

Little is known about the alteration of circulating endothelial progenitor cells (CEP) counts during neoadjuvant chemotherapy. Investigators’ goal was to reveal the alteration in CEP counts in association with response to neoadjuvant chemotherapy in patients with breast cancer. CEP cell counts increased after the initiation of chemotherapy. [npj Precis Oncol]
Full Article

The authors examine potential candidate molecules that may mediate the positive effects of islet endothelial cells on beta cell survival and function under normal conditions. They explore possible mechanisms underlying the development of islet endothelial dysfunction in diabetes and review therapeutic options for ameliorating this aspect of the islet lesion in type 2 diabetes. [Diabetologia]
Abstract

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Genentech announced that the U.S. Food and Drug Administration (FDA) approved Lucentis® for the monthly treatment of all forms of diabetic retinopathy. With this approval, Lucentis becomes the first and only FDA-approved medicine to treat diabetic retinopathy in people who have been diagnosed either with or without diabetic macular edema, a complication of diabetic retinopathy that causes swelling in the back of the eye. [Genentech, Inc.]
Press Release

The University of New Mexico (UNM) is being recognized by the Angioma Alliance as a Clinical Center of Excellence in treating cavernous angioma – only the second such designation in the country. [The University of New Mexico Health Sciences Center]
Press Release

Almost every scientist agrees: Applying for research funding is a drag. Writing a good proposal can take months, and the chances of getting funded are often slim. Funding agencies, meanwhile, spend more and more time and money reviewing growing stacks of applications. That’s why two researchers are proposing a radically different system that would do away with applications and reviews; instead scientists would just give each other money. [ScienceInsider]
Editorial

When the European Union expanded in the 2000s, it had a negative impact on scientific collaborations between researchers in new member countries and elsewhere, a study has found. [Nature News]
Editorial