"I don’t usually wish ex-girlfriends Happy Birthday. But Betty’s special. Happy Birthday to the one and only, Betty White," followed by a birthday cake emoji.

The duo are both renowned for their quick wit, and have known each other since she portrayed his grandmother in the 2009 rom-com, The Proposal, alongside Sandra Bullock.

Sandra Bullock, Reynolds and White filmed a GAS Funny or Die promotional video for the film, and it seems they've been best friends ever since.

After Deadpool premiered in 2016, White made her own review for the flick; "Hello, I just saw the most anticipated movie of the year," White said about the Reynolds-made movie, while lounging in a red velvet chair.

"It was glorious. Once in a generation, a movie comes along that your whole family will love. If your family is a f*cking group of ass-kissing inbreds," she jokingly dead-panned. "Plus, Ryan Reynolds looks so f*cking handsome in his red leather suit."

Reynolds wished White a happy birthday back in 2018 with an amusing photo of himself wearing his Deadpool costume on Instagram, holding a martini and hot dog.