Skin care practices play an important role in the health of well newborns and hospitalized neonates. Fortunately, for many aspects of neonatal skin care, there exist evidence- or consensus-based recommendations to guide best practices. Based on our review of the recent medical literature, we include in this manuscript the current recommendations regarding neonatal skin cleansing and antisepsis; umbilical cord care; use of emollients; and prevention of diaper dermatitis. In addition, we review the recommended practices for preventing and treating pressure ulcers, wounds, and other skin injuries in hospitalized neonates.