On large angular scales (greater than about 60 degrees), the two-point angular correlation function of the temperature of the cosmic microwave background (CMB), as measured (outside of the plane of the Galaxy) by the Wilkinson Microwave Anisotropy Probe, shows significantly lower large-angle correlations than expected from the standard inflationary cosmological model. Furthermore, when derived from the full CMB sky, the two lowest cosmologically interesting multipoles, the quadrupole (l=2) and the octopole (l=3), are unexpectedly aligned with each other. Using randomly generated full-sky and cut-sky maps, we investigate whether these anomalies are correlated at a statistically significant level. We conclusively demonstrate that, assuming Gaussian random and statistically isotropic CMB anisotropies, there is no statistically significant correlation between the missing power on large angular scales in the CMB and the alignment of the l=2 and l=3 multipoles. The chance to measure the sky with both such a lack of large-angle correlation and such an alignment of the low multipoles is thus quantified to be below 10^{-6}.