It depends if you want to do it in 3D or 2D. In 3D you have 3D models and just set the camera at a specific angle.For 2D you would draw your sprites in a isometric perspective and set your camera to orthographic.I've never done a pure isometric game but I'd like to give it a try someday, should be interesting to try to translate grid pathfinding into a 2D isometric grid. Cheers!