ST. LOUIS – Motorists traveling into downtown St. Louis should be aware of some overnight lane closures into the weekend. Two lanes will be closed westbound I-44 from Washington to Lafayette from 7:30 p.m. to 5 a.m. nightly starting Thursday, September 21 until Sunday, September 24. In addition, one lane will be closed on the westbound I-64 ramp to westbound I-44/southbound I-55.