Ampullary adenocarcinoma, arising at the ampulla of Vater in the duodenum, is a gastrointestinal malignancy often treated with surgical resection with curative intent. However, the histopathologic characteristics of the resected tumor that may help predict the course of the disease are unknown. This retrospective cohort study enrolled patients who underwent pancreatoduodenectomy with curative intent for […]

1. In this randomized controlled trial, patients who received a donor fecal microbiota transplant (FMT) had a higher rate of steroid-free remission at 8-weeks than those who a received autologous FMT. 2. Donor FMT was also associated with better clinical response and clinical remission. Evidence Rating Level: 1 (Excellent) Study Rundown: Ulcerative colitis (UC) is […]

1. A hybrid minimally invasive esophagectomy approach (Ivor-Lewis esophagectomy) was found to have lower rates of intraoperative and postoperative complications after 30 days as compared to an open esophagectomy approach. 2. Disease-free survival and overall survival, though not statistically significant, trended towards higher rates with the minimally invasive hybrid approach. Evidence Rating Level: 1 (Excellent) […]

1. Over one quarter of patients required revision surgery (including conversion to another procedure, corrective surgery, and reversal surgery) after initial bariatric surgery in a cohort of Swedish patients. 2. Revision surgery was much less common after gastric bypass compared with banding or vertical banded gastroplasty. Evidence Rating Level: 2 (Good). Study Rundown: Obesity is […]

Hepatocellular carcinoma (HCC) is a rapidly increasing cause of morbidity and mortality in patients affected by HIV. However, the impact of HIV infection on HCC prognosis is unclear. Previous studies have provided both null results and evidence of association between HIV and HCC prognosis, but have been characterized by a lack of geographic diversity. In […]

Non-alcoholic steatohepatitis (NASH), the most common chronic liver disease in the United States, puts patients at increased risk of developing cirrhosis and hepatocellular carcinoma. Patients with NASH are also at an increased risk of experiencing cardiovascular events and overall mortality. Pegbelfermin (BMS-986036) is a PEGylated human fibroblast growth factor 21 (FGF21) that has been previously […]

1. Among average-risk adults, negative findings of a screening colonoscopy was linked to reduced risk of colorectal cancer and colorectal cancer related-deaths compared to individuals who had never been screened. 2. The risk reduction associated with negative findings at screening was attenuated with time but was still significantly lower at the guideline-recommended 10-year follow-up. Evidence […]

1. The biosimilar to infliximab, CT-P13 was shown in this study to have equivalent efficacy to the anti tumor-necrosis factor (TNF) monoclonal antibody for Crohn’s treatment. 2. There was no significant safety differences observed in this study between the two treatments for Crohn’s disease. Evidence Rating Level: 2 (Good) Study Rundown: Crohn’s disease is managed […]