Kommentare 1

Several meta-analyses have been published on the efficacy of -receptor antagonists in terms of fragment elimination after SWL. For further information and comparison the reader is referred to a recent article on the same subject [1]. Most reports have had the focus on results following treatment of ureteral stones. The advantage of this study, and in that referred to above,is that in addition to patients with ureteral stones, also those with renal stones [1] and steinstrasse were included in the evaluation. Altogether the authors succeeded to get almost 1000 patients in the treated as well as in the control groups.

Improved fragment elimination was recorded and there was also a shorter time to fragment/stone expulsion. It is of interest to note that expulsion rate expressed as risk ratio was higher for large than small stones. The recorded increased expulsion rate for renal stones is particularly interesting and valuable information. The analysis of reported data confirmed previously reported observations on reduced pain experience and also that the side effects of this pharmacological treatment usually were mild. Most studies were carried out with daily doses of 0.4 mg of tamsulosin, but if this dose is superior to 0.2 mg is only vaguely suggested in this report.

Several meta-analyses have been published on the efficacy of -receptor antagonists in terms of fragment elimination after SWL. For further information and comparison the reader is referred to a recent article on the same subject [1]. Most reports have had the focus on results following treatment of ureteral stones. The advantage of this study, and in that referred to above,is that in addition to patients with ureteral stones, also those with renal stones [1] and steinstrasse were included in the evaluation. Altogether the authors succeeded to get almost 1000 patients in the treated as well as in the control groups.
Improved fragment elimination was recorded and there was also a shorter time to fragment/stone expulsion. It is of interest to note that expulsion rate expressed as risk ratio was higher for large than small stones. The recorded increased expulsion rate for renal stones is particularly interesting and valuable information. The analysis of reported data confirmed previously reported observations on reduced pain experience and also that the side effects of this pharmacological treatment usually were mild. Most studies were carried out with daily doses of 0.4 mg of tamsulosin, but if this dose is superior to 0.2 mg is only vaguely suggested in this report.
Reference
1. Chen K, Mi H, Xu G, Liu L, Sun X, Wang S, Meng Q, Lv T.The Efficacy and Safety of Tamsulosin Combined with Extracorporeal Shockwave Lithotripsy for Urolithiasis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.J Endourol. 2015 Jun 17. [Epub ahead of print]