History: A 76 y/o man presented with spontaneous bleeding from left eye for 3 days.
A black mass was present on the surface of the left eye for an unknown duration of time. He had a foreign body sensation but no pain.
His right eye was enucleated in 1970 following an automobile accident.
His left eye was severely injured in a fight in 1979 leaving him with no perception of light. There was no recent history of ocular or facial trauma.

Findings: CT Scan:
- The CT scan revealed an absent right eye.
- On the left side there was reasonably normal-sized eye and on the surface of the eye there was an irregular soft tissue prominence.
- The globe itself contained calcification (bone) and soft tissue.
Histopathology:
- There was intraocular & extraocular tumor.
- The tumor was composed of small and large, bizarre tumor cells which had epithelioid cell features.
- Many of the cells were pigmented and stained for melanin. There were areas containing many balloon cells.
- The eviscerated intraocular contents also showed large areas of small and large epithelioid melanoma cells.
- Fragments of bone and degenerated uveal tissue were present.
Immunopathology:
- The following stains were positive: HMB-45, MEL IP and XIAP.
- Stains for a variety of cytokeratins and EMA were negative.
Final Diagnosis:Melanoma , epithelioid cell type arising in the uveal tract.

Dxhow: histology

Exam: The man was in good health and took no medications.
Ocular Examination:
- He was status post enucleation, right eye.
- The left eye was blind and “phthisical”.
- There was a large, black and bloody mass measuring 15x15x5mm extending from the surface of the globe.
- He was placed on antibiotics and given a tetanus booster and sent for a CT scan.

History: A 76 y/o man presented with spontaneous bleeding from left eye for 3 days.
A black mass was present on the surface of the left eye for an unknown duration of time. He had a foreign body sensation but no pain.
His right eye was enucleated in 1970 following an automobile accident.
His left eye was severely injured in a fight in 1979 leaving him with no perception of light. There was no recent history of ocular or facial trauma.

Findings: CT Scan:
- The CT scan revealed an absent right eye.
- On the left side there was reasonably normal-sized eye and on the surface of the eye there was an irregular soft tissue prominence.
- The globe itself contained calcification (bone) and soft tissue.
Histopathology:
- There was intraocular & extraocular tumor.
- The tumor was composed of small and large, bizarre tumor cells which had epithelioid cell features.
- Many of the cells were pigmented and stained for melanin. There were areas containing many balloon cells.
- The eviscerated intraocular contents also showed large areas of small and large epithelioid melanoma cells.
- Fragments of bone and degenerated uveal tissue were present.
Immunopathology:
- The following stains were positive: HMB-45, MEL IP and XIAP.
- Stains for a variety of cytokeratins and EMA were negative.
Final Diagnosis:Melanoma , epithelioid cell type arising in the uveal tract.

Dxhow: histology

Exam: The man was in good health and took no medications.
Ocular Examination:
- He was status post enucleation, right eye.
- The left eye was blind and “phthisical”.
- There was a large, black and bloody mass measuring 15x15x5mm extending from the surface of the globe.
- He was placed on antibiotics and given a tetanus booster and sent for a CT scan.