Two more New Yorkers who contracted swine flu have died — bringing the number of city deaths from the virus to four, officials said yesterday.

The Department of Health would identify the latest fatalities only as a 41-year-old woman from Queens and a 34-year-old man from Brooklyn who both died Friday.

The department said autopsies would be conducted by early next week, but that the H1N1 virus was confirmed late Monday in both victims.

Neither of them had been hospitalized prior to their deaths and neither worked at a school, officials added.

As of yesterday, the flu had generated 2,000 hospital visits per day, hospitalized more than 130 people and shuttered 47 public schools citywide, officials said.

There have been 330 confirmed cases of swine flu in the city, officials said.

City Health Commissioner Dr. Thomas Frieden stressed that underlying medical conditions — such as asthma, diabetes, heart and lung disease, or weakened immune systems — amplified the dangers of what was generally as mild as seasonal flu.

“Every death we’ve had in New York City — and ’til now, every case of severe illness that we’ve documented — has been in someone with an underlying condition,” he said.

The city has refused to specify the underlying conditions of the latest victims.

On Sunday, the city’s second swine flu death was made public — a 55-year-old Queens woman whom sources identified yesterday as Danita Lee. She died Saturday.

Workers at the nonprofit FEGS Health and Human Services System in The Bronx — where Lee and her twin sister took classes for adults with disabilities, according to sources — said they were upset about the handling of the incident.

“The building should have been closed down and cleaned thoroughly,” said one staffer, who asked not to be identified by name. “If a parent isn’t asking any questions, they’re not telling them.”

Administrators at the program declined to comment, citing confidentiality.

City officials also announced five new school closures beginning today — which will join eight other schools set to remain closed for at least one more day.

Nine other schools previously closed are scheduled to reopen today. They will join 20 other schools that reopened yesterday — including IS 238 in Queens, from where assistant principal Mitchell Wiener on May 17 became the city’s first swine flu fatality.

Citywide school attendance was 82 percent yesterday, compared with 87.1 percent on the first Tuesday of the month, Department of Education officials said.

Attendance was 82.6 percent in Queens, the borough that’s been hardest hit with swine flu thus far — about 6 percent less than the first Tuesday in May.

Meanwhile, a fifth Brooklyn yeshiva will close today because of flu fears.