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Doctor's Best Fully Active Folate is a dietary supplement in capsules with the most bioactive, stable form of folate as the glucosamine salt of (6S)-5-methyltetrahydrofolic acid (5-MTHF). Folates are involved in the regulation of growth and cell function and division, influence beneficially the nervous system and the brain, prevent neural tube defecits in the foetus, have a positive impact on the development of newborns and contribute to normal blood production.

Folic acid and folatesFolic acid (vitamin B9), contrary to the common view, is not the same as folate. Folates are the general name for its natural derivatives with similar properties whereas folic acid is a synthetic form of vitamin B9. Unlike folates, folic acid is not converted into the bioactive vitamin B9 in the digestive system but mainly in the liver, which is less efficient and much slower. The body needs more time to produce an active form of vitamin B9. In some cases, it may have a problem with metabolising fully even small doses of the compound.

The formulation contains the most bioactive form of folate as the glucosamine salt of (6S)-5-methyltetrahydrofolic acid (5-MTHF).

Natural and the most richest dietary sources of folates are: green vegetables, legumes, yeast, yolks, liver and citruses. It is worth noting that natural folates are not stable because they are sensitive to among others, light, temperature, oxygen and thermal processing.

Maintaining normal and stable folate levels prevents impaired DNA methylation, abnormalities in the synthesis of purines and pyrimidines and hyperhomocysteinemia. Folate metabolism is also associated with the methylation of neurotransmitters and phospholipids which are a major constituent of cell membranes, histones, myelin and hormones. Adequate folate intake is critical to normal metabolism of amino acids, including cysteine, glycine, serine and methionine. Folates are involves in many biological processes inside a cell and their normal levels reduce the risk of cardiovascular diseases and neurological and haematopoietic disorders.

L-5-methyltetrahydrofolate (5-MTHF) is an important element in the production of methionine from homocysteine. Impaired homocysteine metabolism results in its accumulation in a cell and consequently its transfer to the blood. Depending on the severity of disorders, serum homocysteine levels may increase differently.Its overaccumulation is called hyperhomocysteinaemia, which is believed to be one of the high-risk factors for cardiovascular and neurodegenerative diseases, birth defects and cancer.

A particularly important group in terms of folate supplementation are women who are planning to have a baby and pregnant and breastfeeding women. Proper folate intake by pregnant women may reduce the risk of numerous complications, including: miscarriage, stillbirth, foetal growth restriction and birth defects. The next interesting aspect of adequate folate supply by mothers during the prenatal period is a reduction in the risk of impaired mental development in children. Folates affect the growth and division of glial cells, neurons and are also involved in the production of neurotransmitters, i.e. serotonin, noradrenaline, adrenaline and dopamine, which promote the development of their nervous system even after the closure of the neural tube.

Inadequate folate intake is not the only reason why their supplementation is recommended. Many modern scientific studies provide evidence that a large part of the population suffers from genetic deficiencies of enzymes which enable the body to metabolise the frequently supplemented folic acid into active coenzymes. These deficiencies are mainly associated with a mutation of the MTHFR gene.

Unlike folic acid, 5-MTHFR in this formulation is an active form of folate and may get directly into a cell, passing over many enzymatic transformations which may reduce its effectiveness

To sum up, Doctor's Best Fully Active Folate is a dietary supplement which enriches your diet with folates that are extremly vital to normal functioning of the body. Folate supplementation is recommended especially to all individuals who are at risk of deficiency, in particular: pregnant women, newborns and the elderly.

Adequate folate intake may promote healthy brain development of the foetus and its function in adults. It has also a major role in maintaining mental and emotional health.

Doctor's Best Fully Active Folate is a dietary supplement in capsules with the most bioactive, stable form of folate as the glucosamine salt of (6S)-5-methyltetrahydrofolic acid (5-MTHF). Folates are involved in the regulation of growth and cell function and division, influence beneficially the nervous system and the brain, prevent neural tube defecits in the foetus, have a positive impact on the development of newborns and contribute to normal blood production.

Folic acid and folatesFolic acid (vitamin B9), contrary to the common view, is not the same as folate. Folates are the general name for its natural derivatives with similar properties whereas folic acid is a synthetic form of vitamin B9. Unlike folates, folic acid is not converted into the bioactive vitamin B9 in the digestive system but mainly in the liver, which is less efficient and much slower. The body needs more time to produce an active form of vitamin B9. In some cases, it may have a problem with metabolising fully even small doses of the compound.

The formulation contains the most bioactive form of folate as the glucosamine salt of (6S)-5-methyltetrahydrofolic acid (5-MTHF).

Natural and the most richest dietary sources of folates are: green vegetables, legumes, yeast, yolks, liver and citruses. It is worth noting that natural folates are not stable because they are sensitive to among others, light, temperature, oxygen and thermal processing.

Maintaining normal and stable folate levels prevents impaired DNA methylation, abnormalities in the synthesis of purines and pyrimidines and hyperhomocysteinemia. Folate metabolism is also associated with the methylation of neurotransmitters and phospholipids which are a major constituent of cell membranes, histones, myelin and hormones. Adequate folate intake is critical to normal metabolism of amino acids, including cysteine, glycine, serine and methionine. Folates are involves in many biological processes inside a cell and their normal levels reduce the risk of cardiovascular diseases and neurological and haematopoietic disorders.

L-5-methyltetrahydrofolate (5-MTHF) is an important element in the production of methionine from homocysteine. Impaired homocysteine metabolism results in its accumulation in a cell and consequently its transfer to the blood. Depending on the severity of disorders, serum homocysteine levels may increase differently.Its overaccumulation is called hyperhomocysteinaemia, which is believed to be one of the high-risk factors for cardiovascular and neurodegenerative diseases, birth defects and cancer.

A particularly important group in terms of folate supplementation are women who are planning to have a baby and pregnant and breastfeeding women. Proper folate intake by pregnant women may reduce the risk of numerous complications, including: miscarriage, stillbirth, foetal growth restriction and birth defects. The next interesting aspect of adequate folate supply by mothers during the prenatal period is a reduction in the risk of impaired mental development in children. Folates affect the growth and division of glial cells, neurons and are also involved in the production of neurotransmitters, i.e. serotonin, noradrenaline, adrenaline and dopamine, which promote the development of their nervous system even after the closure of the neural tube.

Inadequate folate intake is not the only reason why their supplementation is recommended. Many modern scientific studies provide evidence that a large part of the population suffers from genetic deficiencies of enzymes which enable the body to metabolise the frequently supplemented folic acid into active coenzymes. These deficiencies are mainly associated with a mutation of the MTHFR gene.

Unlike folic acid, 5-MTHFR in this formulation is an active form of folate and may get directly into a cell, passing over many enzymatic transformations which may reduce its effectiveness

To sum up, Doctor's Best Fully Active Folate is a dietary supplement which enriches your diet with folates that are extremly vital to normal functioning of the body. Folate supplementation is recommended especially to all individuals who are at risk of deficiency, in particular: pregnant women, newborns and the elderly.

Adequate folate intake may promote healthy brain development of the foetus and its function in adults. It has also a major role in maintaining mental and emotional health.

Directions for use

Dosage

Take 1 capsule daily, preferably between meals, or as recommended by a nutritionally-informed physician.

RECOMMENDATIONS OF MUSCLE-ZONE EXPERTJakub kola

The supplement may contribute significantly to reducing the risk of having a child with a brain or spinal cord defect, promotes normal blood production, supports a healthy immune system and helps reduce fatigue.

It is recommended especially to women planning pregnancy or who are pregnant or breast-feeding and individuals with a mutation of the MTHFR gene. It is said that even one in two individuals may have a deficiency of the enzyme responsible for converting folic acid into an active form.

Manufacturer

Physician-founded in 1990, Doctor’s Best is a science-based nutritional supplement company, offering more than 200 products, made primarily with branded ingredients that are thoroughly researched, manufactured to the highest quality standards, and rigorously tested every step of the way—from raw materials to finished product. We use only cGMP-certified manufacturing facilities. Doctor’s Best is committed to transparency through education and communication and strives to be crystal clear in what we offer, why and how we offer it.

Vitamin B9 (Folic acid)

Information

Vitamin B9 (folic acid, folacin, vitamin M) is part of a complex of B vitamins soluble in water. It takes part in the production of red blood cells, in cooperation with vitamin B12, preventing anaemia progression, its molecules are involved in catalysis of hematopoietic processes. Together with vitamins B6 and B12 it helps in the treatment of hyperhomocysteinemia. It eliminates disturbances in the gastrointestinal tract. It affects the proper functioning of the immune system. Necessary during pregnancy, because its deficiency causes neural tube defects in the fetus. The natural ingredient of yeast, eggs, liver, green vegetables and it is synthesized in the gastrointestinal tract by intestinal bacteria.
Dosage: The daily requirement is 0.1-0.2 mg.

Quatrefolic

Information

Quatrefolic is the glucosamine salt of (6S)-5-methyltetrahydrofolate and also an active form of folic acid. It is an innovative nutrient (fourth generation folate) which is well soluble in water and thus absorbed effectively by the body. As an organic compound ranked among B vitamins, it is necessary for normal functioning at the cellular level.

Adding folates to a diet is recommended especially to pregnant and lactating women. These compounds may contribute to healthy foetal development. According to studies, their intake may reduce the incidence of pregnancy complications.

Quatrefolic may affect the metabolism of homocysteine whose levels increase in the body over time. Adding it to a diet may thus prevent the development of dementia and maintain healthy cognitive functions which is vital to adults, especially the elderly.

5-methyltetrahydrofolate (5-MTHF)

Information

What is 5-methyltetrahydrofolate (5-MTHF)?

5-methyltetrahydrofolate (5-MTHF) is a methylated, biologically active form of folate. It is especially willingly used by people with folic acid metabolism disorders, especially by polymorphisms of the gene coding the production of methyltetrahydrofolate reductase. Using this form allows to skip narrow gorge created by this polymorphism and enjoy all effects induced by folates. It is also a good substitute for synthetic folic acid (pteroylmonoglutamic acid), which in clinical trials demonstrates the ability to increase the frequency of developing cancers.

Folates, also called vitamin B9 have a wide contribution to the development of the nervous system. They contribute to converting homocysteine to methionine and then to s-Adenosyl methionine, which is the main donor of methyl groups. Thanks to this, the condition of the circulatory system is increased, as the amount of pro-inflammatory homocysteine is decreased and the intensity of the production processes of creatine and neurotransmitter synthesis is higher, which is reflected in the reduction of fatigue and better psychological condition.

5-MTHF in mono-supplements and complex vitamin preparations may be found in the offer of muscle-zone.pl.

Salt

Information

Salt (sodium chloride, or table salt), natural source of electrolytes (chlorine and potassium), regulating water and electrolyte and acid-base balance of the body, affecting the nervous system and blood pressure. Sodium is an essential element for the proper growth. The proper dose of salt prevents overheating of the body and solar stroke. It provides the proper functioning of muscles and nerves the body. Chlorine in combination with sodium, is involved in the digestive process and maintains acid-base balance in the body, as antitoxin removes toxic products of metabolism in the liver. Salt is a flavour component and preservative of many foods, nutritional supplements and mixtures of electrolytes, available at www.muscle-zone.pl

Dosage: no specific standards of consumption, used so as to provide sufficient amount of electrolytes to the body (sodium and chloride).