In 1983, Waltraud Wagner recruited Leidolf, Stephanija Meyer and Maria Gruber to murder patients that were under their care. The murder series is thought to have begun in 1983, when Leidolf was 21 years old. The women would cause their patients to die from an overdose of morphine, insulin, Rohypnol or would drown them.

Not only did Wagner teach Leidolf how to murder her victims, but would also help any of the women who wanted to drown their patients. The women claimed that at first they murdered their patients because they wanted to ease their suffering. Many believe that this eventually changed because they began to murder patients who they found annoying. The remains of the patients were left at the scenes of the crimes. There was not any suspicion as to why the patients were dying.

In 1989, Leidolf went to a local bar with her accomplices and began to discuss how they murdered patients and why they deserved it. They did not realize that there was a doctor sitting at a nearby table who overheard them and promptly went to the police station to report what he had heard. All of the women were arrested 6 weeks later. Leidolf was found guilty of murdering 5 people and was sentenced to life in prison. Wagner was found guilty of 15 murders, 17 attempted murders and 2 assaults, Meyer and Gruber were found guilty of manslaughter and attempted murder charges. It is believed that the women were responsible for the murders of between 48 and 200 people.

In 2008, Leidolf was released on conditional parole and was given a new identity.

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Irene Leidolf was found guilty of murdering five people. Leidolf and her accomplices Stephanija Meyer, Maria Gruber and Waltraud Wagner are thought to have murdered between forty-eight and two-hundred people. We do not currently have information on any of her victims.