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1 Title: Post Exposure Prophylaxis Page 1 of 8 OBJECTIVE To standardize medical care following a Blood or Bodily Fluid Exposure (BBFE). SCOPE All Exposed Individuals (as defined below) who present for post-exposure management of BBFEs. DEFINITIONS Exposed Individual - for the purpose of this policy, an exposed individual shall refer to any individual occupationally exposed to blood or bodily fluid of another individual. BBFE (Blood or Bodily Fluid Exposure) - Any percutaneous (puncture or cut through skin), mucosal (e.g. eyes or mouth) or non-intact dermal (e.g. abraded skin, chapped skin or dermatitis) exposure to blood or a potentially infectious bodily fluid of another individual ( source ). HBV Hepatitis B Virus HCV Hepatitis C Virus HIV Human Immunodeficiency Virus Potentially Infectious Material - Blood, tissue, visibly bloody fluids, semen, vaginal secretions, cerebrospinal fluid, synovial fluid, pleural fluid, peritoneal fluid, pericardial fluid, amniotic fluid and inflammatory exudates are considered potentially infectious materials for HIV, HBV and HCV. Materials which are not considered potentially infectious for HIV, HBV and HCV include feces, urine, nasal secretions, saliva, sputum, sweat, tears and vomitus, unless these materials are visibly bloody. POLICY 1. Upon presentation for post-exposure management of a BBFE, the risk of exposure will be assessed considering the nature and severity of the exposure and the risk level of the source of the blood or bodily fluid. The exposed individual will be appropriately counseled, with care provided according to CDC guidelines and current medical practices, and shall be offered post-exposure prophylaxis if clinically indicated. 2. Attempts will be made to rapidly identify and test the source patient for HIV, HBV and HCV. If HIV positive, attempts will be made to determine the history of antiretroviral drug treatment and/or prior genotypic antiretroviral resistance testing (GART). 3. Baseline testing of the exposed individual will be performed for HIV, HBV and HCV. DMC healthcare workers found to be infected with any of these agents will be subject to the DMC HIV/HBV/HCV Infected Healthcare Worker Policy (1 CLN 023). Those found to be infected on baseline will be referred to their personal physician for management. 4. Informed consent will be obtained prior to testing or treatment. Written consent on a separate consent form is no longer required. The DMC General Consent for Admission and Treatment forms for both inpatient and outpatient have been adapted at the DMC to include consent for HIV testing language. The provider must document in the patient s medical record both the provision of required pretest information and whether the patient declined or agreed to HIV testing. 5. An infectious disease consultation and/or second level counseling by an infectious disease expert shall be arranged whenever indicated. PROVISIONS

2 Title: Post Exposure Prophylaxis Page 2 of 8 1. All DMC employees with BBFEs must complete an incident report and report to their designated DMC OHS clinic (or clinic/emergency department providing back up coverage for DMC OHS after hours) for post-exposure management. 2. Exposed individuals whose initial visit was not at their designated DMC OHS clinic must report to the DMC OHS clinic within 72 hours following the incident. 3. Infectious Disease Specialist consultation may be obtained when clinically indicated by paging the on-call BBFE consultant at DMC phone number Post-Exposure Management for HIV: A. Risk Assessment: Risk for transmission of HIV shall be assessed based upon the exposure material (type of potentially infectious material), the type and severity of sharp or splash exposure, and the source status. The following provide general guidelines for categorizing risk, recognizing that some situations may fall between categories and will require clinical judgment. Consultation with an infectious disease expert shall be sought whenever the clinician is in doubt. 1. Sharp (e.g. needlestick or other sharp object) percutaneous exposures are considered less severe when the puncture is superficial or results from a solid needle. Exposures are considered more severe when the exposure involves a large bore needle, a deep puncture wound, the needle has been in an artery or vein of the source patient, or there is visible blood on the device. 2. Source status shall be classified as follows: a) Class 1 HIV positive - source individual is asymptomatic and/or has a known viral load less than 1500 RNA copies per ml. b) Class 2 HIV positive - source individual is symptomatic, has AIDS, is acutely seroconverting, or is known to have a viral load exceeding 1500 RNA copies per ml. c) Known source; status unknown; no known HIV risk factors d) Known source; status unknown; known HIV risk factors e) Unknown source; not a setting in which exposure to HIV infected persons is likely f) Unknown source; setting in which exposure to HIV infected persons is likely B. Source Testing Following a BBFE, source patient testing shall include a rapid HIV test in order to facilitate decision-making regarding ART. C. Counseling of the individual potentially exposed to HIV shall include: 1. Risk of occupational exposure based on up to date epidemiologic information from the CDC. Currently, the risk of HIV transmission following a typical percutaneous needlestick exposure is believed to be approximately 0.3% (3 per 1,000). The risk for a typical mucosal exposure is believed to be approximately 0.09% (9 per 10,000), and the risk for a typical exposure to non-intact skin is believed to be less. 2. Prevention of secondary transmission to others shall be discussed, including safer sex practices, and the need to avoid blood donation, pregnancy and breast feeding, especially during the first 6 to 12 weeks following exposure. No modifications to an exposed individual s patient-care responsibilities are necessary solely based upon the exposure incident. 3. Safe work practices and prevention of future exposure. 4. The benefits and side effects or risks of antiretroviral therapy (ART) for the prevention of HIV transmission based upon up to date information from the CDC. The counseling should include the following:

3 Title: Post Exposure Prophylaxis Page 3 of 8 a) Current studies suggest that ART may reduce risk of HIV transmission by as much as 80%. As of the publication of the September 20, 2005 MMWR, while many persons have taken ART following BBFE, there have only been 6 cases worldwide of individuals who developed HIV infection despite taking ART. b) Known side effects, risks and potential drug (and herbal agent) interactions with ART. This consideration is especially important for individuals who will be placed on a drug such as Kaletra (lopinavir/ritonavir) which contains a protease inhibitor. Such drug interactions may be serious or even life-threatening in some cases. The provider should refer to Appendix 2 and drug packet inserts or consult with a pharmacist when indicated. The individual receiving ART should be advised that evaluation of certain new, severe symptoms should not be delayed. c) Individuals taking Kaletra who rely upon oral contraceptives must be advised to use supplemental contraception, as Kaletra may impair the effectiveness of oral contraceptives. d) There may be yet unknown side effects of these medications. Data regarding the long-term effects in otherwise healthy persons, including mutagenesis, carcinogenesis, teratogenesis, and fertility are lacking or inadequate. D. Consultation with and/or counseling by an Infectious Disease Expert 1 (DMC phone number ) shall be arranged when: 1. Individual is pregnant or breastfeeding 2. Source is known positive and is or has been on ART, or has had genotypic antiretroviral resistance testing (GART) performed. 3. Individual has a pre-existing medical condition which may increase the risks associated with ART (e.g. renal or hepatic disease, bone marrow suppression or disorder). 4. Individual is taking a drug or herbal remedy (such as St. John s Wort) that may interact with ART 5. Individual has previously been treated with ART 6. HIV seroconversion is suspected in the source 7. Initial presentation is delayed (Over hours from time of BBFE) 8. Side effects of ART might require altering the ART regimen 9. Either the treating clinician or the patient have questions which would be best answered by such a consultation. E. Treatment with ART 1. When ART is offered, treatment must begin as soon as possible (preferably within 4 hours of exposure). The ART regimen may be subsequently discontinued or changed to a different regimen if additional data collected changes the recommendation. If the exposure is of high severity and the source is either known HIV positive or known to be at high risk, the patient should be offered the option to begin the first doses of Truvada and Kaletra even while pending the results of source testing. 2. ART will be recommended and/or offered to the exposed individual for Post-Exposure Prophylaxis (PEP) according to the following guidelines. ART is to be provided for 28 days. It is recognized that clinically justified deviations may occur. a) No ART will be provided without counseling and informed consent. The individual must agree to compliance with treatment monitoring and the HIV testing protocol. 1 An additional 24/7 resource is the National Clinicians Post Exposure Prophylaxis Hotline (PEPline) at , which is staffed by physicians and pharmacists trained in BBFE management.

4 Title: Post Exposure Prophylaxis Page 4 of 8 b) All females of reproductive capacity will undergo a rapid pregnancy test, and if pregnant, the case will be discussed with an infectious disease expert prior to beginning ART. Breastfeeding women will be counseled to discontinue breastfeeding for at least 6 weeks. c) If the individual is either known to be positive for HIV or tests positive for HIV on baseline testing, then he or she will be referred to his or her personal physician, and will not be treated with ART. d) Drugs taken by the exposed individual, including over the counter and herbal remedies, and drug allergies will be documented, and consideration be given to known drug interactions prior to beginning ART. e) Sharps Exposures shall be managed based upon the following 4 categories of recommendation: (1) ART not indicated - ART will not be offered by the provider. Circumstances in which ART is not indicated include: (a) HIV negative source (b) No exposure (e.g. intact skin, needle not contaminated with blood or potentially infectious material) (2) ART is Optional, but Recommended Against ART may be elected at the option of the exposed individual. Circumstances include: (a) Known source; Status unknown; No known risk factors (b) Unknown source; Setting not likely for HIV infected individuals (3) ART is Optional with no recommendation for or against - ART may be elected at the option of the exposed individual. Circumstances include: (a) Known source; Status unknown; Risk factors for HIV present (b) Unknown source; Setting is likely for HIV infected individuals (4) ART is recommended: HIV positive source (class 1 or 2) f) Splash Exposures shall be managed based upon the following 4 categories of recommendation: (1) ART not indicated - ART will not be offered by the provider if the source is known to be HIV negative. (2) ART is Optional, but Recommended Against - ART may be elected at the option of the exposed individual. Circumstances include: (a) Small volume; Known source; Status unknown (b) Large volume; Known source; Status unknown, but no known risk factors (c) Small volume; Unknown source (d) Large volume; Unknown source; Setting not likely for HIV infected individuals (3) ART is Optional with no recommendation for or against - ART may be elected at the option of the exposed individual. Circumstances include: (a) Large volume; Known source; Status unknown; Risk factors for HIV present (b) Large volume; Unknown source; Setting is likely for HIV infected individuals (c) Small volume; Class 1 HIV positive source (4) ART is recommended: (a) Large volume; Class 1 HIV positive source (b) Class 2 HIV positive source (regardless of volume)

5 Title: Post Exposure Prophylaxis Page 5 of 8 F. Selection of ART agents 1. When there is no clinical reason for a different selection of agents (e.g. source history of ART treatment, genotypic antiretroviral resistance testing [GART], drug allergies), then the exposed individual will be started on the following standard preferred regimen: Truvada (tenofovir 300mg + emtricitabine 200mg) 1 tablet daily plus Kaletra (lopinavir 200mg + ritonavir 100mg) 2 tablets twice daily. Alternative: Combivir (zidovudine 300mg + lamivudine 150mg) 1 tablet twice daily plus Kaletra 2 tablets twice daily. 2. When there are clinical indications for using another regimen, an infectious disease expert shall be consulted. G. Monitoring ART toxicity Upon beginning ART, baseline tests shall include a CBC, a blood chemistry panel which includes hepatic and renal function tests, a urinalysis, and a blood glucose. Testing shall be repeated and reviewed by the physician every two weeks until two weeks following the completion of ART. Symptoms will be reported to the physician, who will provide treatment as clinically indicated. Blood glucose will be monitored weekly for women who are pregnant and receiving ART. H. Medication intolerance If the exposed individual is experiencing medication intolerance to the extent that compliance may be compromised, an infectious disease expert shall be consulted to consider modifications to the ART regimen. I. Follow up HIV Testing In addition to the baseline HIV test, the exposed individual will be tested for HIV at 6 weeks, 12 weeks and 6 months. If the source was positive for both HCV and HIV, and the exposed individual becomes HCV positive but not HIV positive, then HIV testing will also be performed at 12 months. If the exposed individual should develop an illness compatible with acute retroviral syndrome, then HIV testing will be repeated regardless of the interval since exposure. J. Any exposed individual who is confirmed positive for HIV infection on baseline testing will be referred to his or her personal physician. Any individual who is confirmed positive for HIV infection on follow up testing will be referred to a specialist knowledgeable in the management of HIV infection. K. Testing of the source patient: OHS/ED will alert Administrative Manager/Supervisor of unit to contact attending physician to initiate testing (order as HCW exposure). Attending physician is responsible for counseling the patient. Assistance of Epidemiology with post-test counseling may be requested. 5. Post-Exposure Management for Hepatitis B (HBV): A. Risk Assessment: Risk for transmission of HBV shall be assessed based upon the exposure material (type of potentially infectious material), the type and severity of sharp or splash exposure, and the source status. B. Source Testing When source testing reveals a positive Hepatitis B surface antigen (HBsAg), additional testing for Hepatitis B e antigen (HBeAg) shall be performed to better inform the risk assessment. C. Counseling of the individual potentially exposed to HBV shall include: 1. Risk of occupational exposure based on up to date epidemiologic information from the CDC. The risk for HBV in the exposed individual who has immunity is negligible, and no treatment or special precautions are necessary. The risk for the exposed individual who does not have immunity to HBV of developing clinical hepatitis following a needlestick injury with an HBV positive source can range from approximately 1% to 30%, depending on whether or not the source carries the Hepatitis B e-antigen. This risk can be significantly reduced through post-exposure prophylactic treatment. 2. Prevention of secondary transmission (if exposed to HBV and not immune) to others. The exposed individual should avoid blood, plasma, semen, tissue and organ donation. The CDC does not recommend changes in sexual practices for long-term monogamous partners. Those with multiple sexual partners or in more casual relationships, however, should be counseled to employ safer sex practices (e.g. condoms). The CDC has no recommendations against becoming pregnant or

6 Title: Post Exposure Prophylaxis Page 6 of 8 breastfeeding. No modifications to an exposed individual s patient-care responsibilities are necessary solely based upon the exposure incident. 3. Safe work practices and prevention of future exposure. 4. The benefits and side effects of treatment for individuals who do not have HBV immunity. a) Multiple doses of Hepatitis B Immunoglobulin (HBIg) vaccine alone initiated within one week following percutaneous exposure will reduce the transmission risk by approximately 75%. b) The addition of the Hepatitis B vaccine series following exposure is believed to further reduce transmission risk and will provide the additional protection from future exposures. c) Safety of the vaccines. Common side effects include local soreness at the injection site and sometimes mild to moderate fever. These vaccines are safe for use in pregnancy. d) A Michigan Vaccine Information Sheet (VIS) shall be provided prior to vaccination. D. Management of the HBV exposed (source positive for HBV antigen) individual shall include: 1. Determination of immunity through review of documentation and/or testing for Hepatitis B surface antibody (HBsAb) and surface antigen (HBsAg) if documentation of immunity does not exist. 2. If the exposed individual is known to be immune to HBV, then no further treatment or testing for HBV is required. 3. All exposed individuals who have not been vaccinated for HBV will be offered and strongly encouraged to undergo vaccination, regardless of the exposure risk or source status. 4. If the exposed individual s immune status is negative or unknown, then treatment shall proceed according to current CDC guidelines (MMWR June 29, 2001 if not superceded by more current guidelines; see page 22, table 3). Treatment shall be based upon consideration of both the exposed individual and source status and shall include HBIG and the Hepatitis B vaccine series as clinically indicated. Treatment should be initiated as soon as possible (preferably at the initial patient presentation). When HBIG and/or the Hepatitis B vaccine series are indicated, they should be administered as soon as possible (preferably within 24 hours). If the exposed individual presents late, HBIG may be given up to 7 days following exposure. HBIG and the HBV vaccine may be administered simultaneously in different sites (the HBV vaccine should be administered in the deltoid muscle). E. Follow up shall include: 1. For those who are offered and decline vaccination, follow up testing shall be performed for HBsAg and HBsAb at three months post exposure. For those receiving vaccination, follow up testing shall be performed at 1-2 months after the last dose of vaccine, but not prior to 4 months following HBIG administration. If follow up testing fails to demonstrate immunity, then consideration should be given to additional vaccination in accordance with CDC guidelines. 2. Those initiating the HBV vaccine series will receive their 2 nd and 3 rd doses of vaccine at 1 and 6 months after the first dose. 3. Those who require a 2 nd dose of HBIG shall receive it 1 month after the first dose. 4. Exposed individuals shall report symptoms which may indicate the development of hepatitis (e.g. jaundice, dark urine, nausea, vomiting, right upper quadrant pain, etc.), and present to OHS as soon as possible for follow up evaluation. 5. Any exposed individual who is confirmed positive for HBV infection on baseline testing will be referred to his or her personal physician. Any exposed individual who is confirmed positive for HBV infection on follow up testing will be referred to a specialist knowledgeable in the management of HBV infection.

7 Title: Post Exposure Prophylaxis Page 7 of 8 6. Post-Exposure Management for Hepatitis C (HCV): A. Risk Assessment: Risk for transmission of HCV shall be assessed based upon the exposure material (type of potentially infectious material), the type and severity of sharp or splash exposure, and the source status. B. Counseling of the individual potentially exposed to HCV shall include: 1. Risk of occupational exposure based on up to date epidemiologic information from the CDC. The risk to the individual for acquiring HCV infection following a needlestick injury with an HCV positive source is estimated to be approximately 1.8%. 2. There is no known effective post-exposure prophylaxis for HCV, but follow up testing will be provided. 3. The exposed individual should avoid blood, plasma, semen, tissue and organ donation. The CDC does not recommend changes in sexual practices for long-term monogamous partners. Those with multiple sexual partners or in more casual relationships, however, should be counseled to employ safer sex practices (e.g. condoms). The CDC has no recommendations against becoming pregnant or breastfeeding. No modifications to an exposed individual s patient-care responsibilities are necessary solely based upon the exposure incident. 4. Safe work practices and prevention of future exposure. C. Management and Follow Up of the HCV exposed (source confirmed positive for HCV antigen) individual shall include: 1. If the source was determined positive on an immunoassay test, source status shall be confirmed with qualitative polymerase chain reaction (PCR) testing. 2. Baseline testing of the exposed individual for HCV antibody and ALT. 3. Follow up testing of the exposed individual for HCV antibody and ALT at 3 and 6 months post exposure. 4. Positive HCV immunoassay screening tests will be followed by confirmation testing such as recombinant immunoblot assay (RIBA) or qualitative PCR testing. 5. Any individual who is confirmed positive for HCV on baseline testing will be referred to his or her personal physician. Any individual who is confirmed positive for HCV on follow up testing will be referred to a specialist knowledgeable in the management of HCV infection. 6. Exposed individuals shall report symptoms which may indicate the development of hepatitis (e.g. jaundice, dark urine, nausea, vomiting, right upper quadrant pain, etc.), and present to OHS as soon as possible for follow up evaluation. Questions regarding this policy should be referred to the Chief, Division of Infectious Diseases, Hospital Epidemiologist, Occupational Health Services or (for administrative purposes) or for administrative purposes the SVP, Human Resources. REFERENCES Updated U.S. Public Health Service Guidelines for the Management of Occupational Exposures to HIV and Recommendations for Postexposure Prophylaxis. MMWR September 30, 2005 Vol. 54/No RR-9 Updated U.S. Public Health Service Guidelines for the Management of Occupational Exposures to HBV, HCV, and HIV and Recommendations for Postexposure Prophylaxis. MMWR June 29, 2001 Vol. 50/No RR-11 ADMINISTRATIVE RESPONSIBILITY

8 Title: Post Exposure Prophylaxis Page 8 of 8 The DMC Executive Vice President/COO has overall administrative responsibility for this policy. The DMC Executive Vice President Chief Medical Officer has day to day operational responsibility for this policy. APPROVAL This policy has been approved and is duly authorized by DMC management. The posting of the policy on the DMC intranet signifies that it is in full force and effect. REVIEW DATE 04/2014 SUPERSEDES 08/00, 08/01, 02/05, 01/08 Please check one: This policy is: New Reviewed xrevised Deleted Policy(ies)

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