..Here we describe how researchers can determine the correlates of immune protection for an HIV/AIDS vaccine, particularly in the context of the RV144 trial, and we discuss the terminology used to describe correlates and surrogates...

Morgane RollandDepartment of Microbiology, University of Washington, Seattle, Washington, United States of AmericaPLoS ONE 6:e17969. 2011

..Furthermore, since peptides were not recognized based on their frequency in the population, it remains unclear by which mechanisms variability-inclusive antigens (i.e., constructs enriched with frequent variants) expand CTL recognition...

Genetic impact of vaccination on breakthrough HIV-1 sequences from the STEP trial

..Furthermore, the diversity of HIV strains coupled with complex and individual-specific patterns of CTL escape did not reveal shared sequence characteristics of acute infection that could be harnessed for vaccine design...