1Biophysics, Medical College
of Wisconsin, Milwaukee, WI, United States; 2Pathology, Medical
College of Wisconsin, Milwaukee, WI, United States; 3Radiology,
Medical College of Wisconsin, Milwaukee, WI, United States; 4Neurology,
Medical College of Wisconsin, Milwaukee, WI, United States; 5Neurosurgery,
Medical College of Wisconsin, Milwaukee, WI, United States

The detection of invading brain tumor cells, beyond
the traditional contrast-enhancing regions, continues to be a challenge for
the treatment of brain tumors.Decreases in apparent diffusion coefficient (ADC) have been shown to
correlate with an increase in tumor cellularity.Graded functional diffusion maps (gfDM)
result from the subtraction and thresholding of ADC maps from multiple time
points. In this study of invasive glioblastoma, we correlate in-vivo
biomarkers for blood volume, and increased cellularity with ex-vivo brain
tissue.