(Nov. 5, 2018) -- To expand the understanding and explanation of Alzheimer’s disease, Austin-based business leader James Truchard, retired president and CEO of National Instruments, has given a $5 million gift to the UTSA College of Sciences to establish the Oskar Fischer Project. The initiative will engage the world’s brightest minds in a comprehensive literature review with the goal of synthesizing that information into one simple explanation for the cause of Alzheimer’s disease. The challenge was announced today during the Society for Neuroscience’s annual meeting, an international gathering of nearly 30,000 scientists taking place through Nov. 7 in San Diego.

The Oskar Fischer Prizes will include a grand prize of $2 million, two second place prizes of $500,000 each and four third place prizes of $250,000 each. Collectively, the monetary awards are the world’s largest prizes of their kind.

Oskar Fischer

Through personal research, Truchard, 75, was introduced to the work of Oskar Fischer (1876-1942), a Jewish pioneer in neuroscience who studied dementia at the same time as Alois Alzheimer. In 1900, Fischer began working at Charles University’s German University, based in Prague. His research led to the identification of senile plaques (then called neuritic plaques), the signature lesions of Alzheimer’s disease.

Fischer hypothesized that the plaques were associated with presbyophrenia, then characterized as a form of senile dementia marked by memory loss, memory distortions and disorientation. He published on 12 patients with plaques and tangles, protein strands that appear during Alzheimer’s disease, in 1907, the same year that Alzheimer published on one patient with early onset Alzheimer’s.

Fischer remained at the German University until he was removed in 1939. Two years later, he was sent to Theresienstadt in Terezín, a way station for Auschwitz and Treblinka. He died in 1942, unable to survive the harsh conditions of the concentration camp.

“A century has passed since Oskar Fischer’s seminal work, and tens of billions have been spent around the world on research and potential cures. Over 130,000 research papers have been published and yet no definitive explanation and cure for Alzheimer’s has been found,” said Truchard. “We need to look at Alzheimer’s as a big complex puzzle with a missing piece. We need a brilliant individual who can take all of the pieces and consider what each offers, and then develop one explanation that fits because it pulls all of the pieces together and makes the puzzle whole.”

According to the World Alzheimer Report 2018 by Alzheimer’s Disease International (ADI), an estimated 50 million people worldwide are living with dementia at a cost of $1 trillion to the global economy. That population is expected to more than triple by the year 2050, according to ADI, which also reports that the global ratio of publications on neurodegenerative disorders versus cancer is just one to 12.

George Perry is the Chief Scientist of the UTSA Brain Health Consortium and an internationally recognized Alzheimer’s disease researcher.

“The Oskar Fischer Project will take a new systems approach to the research on Alzheimer’s, building on the work Oskar Fischer started over a century ago,” said George Perry, chief scientist of the UTSA Brain Health Consortium. “Jim Truchard’s generous gift will create an international forum to assess that work and bring forward an explanation that will advance society’s understanding of the disease.”

UTSA, a world leader in brain health research, will incubate the two-year challenge. In the UTSA Brain Health Consortium, 38 of the nation’s brightest scientists are engaged in research on brain mechanisms and therapeutics. UTSA researchers have expertise in neurodegenerative disease, brain circuits and electrical signaling, traumatic brain injury, regenerative medicine and stem cell therapies, medicinal chemistry and drug design, neuroinflammation, and psychology.

“Through Jim Truchard’s support, the Oskar Fischer Project will accelerate our shared mission of unraveling the mysteries of neurodegeneration through engagement with the smartest thinkers around the world,” said UTSA President Taylor Eighmy.

Truchard added, “I truly believe that Alzheimer’s disease is multifaceted; it’s about lifestyle, heredity and brain regression. It’s important to look at all possible solutions. This contest will bring together the world’s best minds to consider the entire story.”

UTSA will work closely with an interdisciplinary committee of outstanding scientists from Texas to award the Oskar Fischer Prizes. The call for proposals will open in February 2019 and will continue through the two-year term of the project.

Winterlude Concert Series 2018: Ensemble Performances

The second of three in the annual holiday concert series which will feature the Chamber Singers (Santa Baby), Saxophone Ensemble (Sleigh Ride), Jazz Ensemble (Sugar Rum Cherry), Flute Ensemble and more performing holiday favorites. Admission $10.

UTSA Football vs. North Texas

College of Engineering Tech Symposium

This event showcases innovative student projects and research performed across multiple disciplines. The symposium is designed to provide a public venue where UTSA senior engineering students to present advances achieved in their design projects.

OIT Digital Experience (DEx) Lab Grand Opening

Join the Office of Information Technology for the grand opening of the Digital Experience Lab (DEx Lab). The DEx Lab is open to the entire UTSA community and contains innovative learning tools and serves as a virtual reality lab.

UTSA Mexican American Studies program to celebrate 25 years

The College of Education and Human Development’s Mexican American Studies (MAS) program will celebrate its 25thanniversary with a special celebration on Thursday, Nov. 29 at 6 p.m. at the UTSA Downtown Campus. The event is free and open to the public.

UTSA Dance Showcase: Taking Flight

The students will perform in a showcase of modern, jazz, and ballet dances choreographed by Megan Rulewicz, Randi Miles and Michelle Pietri. Tickets are $10. Parking is free in the Cattleman's Square Lot.

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The University of Texas at San Antonio is dedicated to the advancement of knowledge through research and discovery, teaching and learning, community engagement and public service. As an institution of access and excellence, UTSA embraces multicultural traditions and serves as a center for intellectual and creative resources as well as a catalyst for socioeconomic development and the commercialization of intellectual property - for Texas, the nation and the world.

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