About:Children’s Hospitals and Clinics of Minnesota, working with CareFusion and Cerner, became the first hospital system to achieve interoperability between smart intravenous (IV) infusion pumps and an electronic health record (EHR) system for both large volume and syringe IV infusions. IV infusion errors are the medication errors with the greatest potential for harm. Barcode medication administration systems that help safeguard a single dose provide only limited safety value for high-risk IV infusions. Now smart pump-EHR interoperability makes it possible to pre-populate the pump with the ordered infusion parameters transmitted directly from the EHR, opening “a new era in IV medication safety.”