chelate

chelate

1. to combine with a metal in complexes in which the metal is part of a ring.

2. by extension, a chemical compound in which a metallic ion is sequestered and firmly bound into a ring within the chelating molecule. Chelates are used in chemotherapy of metal poisoning.

che·late

(kē'lāt),

1. To effect chelation.

2. Pertaining to chelation.

3. A complex formed through chelation.

chelate

/che·late/ (ke´lāt)

1. to combine with a metal in complexes in which the metal is part of a ring.

2. by extension, a chemical compound in which a metallic ion is sequestered and firmly bound into a ring within the chelating molecules. Chelates are used in chemotherapy of metal poisoning.

chelate

(kē′lāt′)

adj.Zoology

Having chelae or resembling a chela.

n.Chemistry

A chemical compound in the form of a heterocyclic ring, containing a metal ion attached by coordinate bonds to at least two nonmetal ions.

tr.v.che·lated, che·lating, che·lates

1. Chemistry To combine (a metal ion) with a chemical compound to form a ring.

2. Medicine To remove (a heavy metal, such as lead or mercury) from the bloodstream by means of a chelate, such as EDTA.

che′lat·a·ble adj.

che·la′tion n.

che′la′tor n.

chelate

[kē′lāt]

Etymology: Gk, chele, claw

1v, to form a bond, thus creating a ringlike complex. An example is the interaction of a metal ion and two or more polar groups of a single molecule.

2n, (in medicine) any coordination compound composed of a central metal ion and an organic molecule with multiple bonds arranged in ring formations, used especially in chemotherapeutic treatments for metal poisoning.

3adj, pertaining to chelation.

che·late

(kē'lāt)

1. To effect chelation.

2. Pertaining to chelation.

3. A complex formed through chelation.

chelate

possessing claws or pincer-like appendages.

to combine with a metal ion to form a stable compound.

Chelate

A chemical that binds to heavy metals in the blood, thereby helping the body to excrete them in urine.

chelate

to combine with a metal in complexes in which the metal is part of a ring; by extension, a chemical compound in which a metallic ion is sequestered and firmly bound into a ring within the chelating molecule. Chelates are used in treatment of metal poisoning.

In children being treated for Pb poisoning by EDTA chelation therapy, elevated urinary ALA was significantly associated with higher chelatable Pb and with a decrease in the chelatable Zn/Pb ratio to 18.

Regulation of expression occurs by means of an interaction between the iron regulatory protein, a molecule that senses changes in the chelatable intracellular iron pool (27-29), and iron-responsive elements located on untranslated regions of ferritin and TfR mRNAs (30, 31).

Posttranscriptional regulation occurs by means of an interaction between IRPs, proteins that sense changes in the chelatable intracellular iron pool, and iron-responsive elements located on untranslated regions of transferrin receptor mRNA and ferritin mRNA (12-14).

This regulation occurs by means of an interaction between the iron regulatory protein (IRP)', a molecule that senses changes in the chelatable intracellular iron pool X14-16], and iron-responsive elements (IREs) located on untranslated regions of ferritin and transferrin receptor mRNAs X16-18].

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