Excreted by tubular secretion and can be blocked by probenecid
Dosage adjustment for renal insufficiency [exceptions?]
Generally well-tolerated
GI [diarrhea], rash
Can give rise to allergic reactions - immediate, accelerated and late
Most important adverse effect – hypersensitivity

Fluoroquinolones

Side effects: GI, CNS [dizziness, seizures], Achilles tendon rupture
Severe cases of hyperglycemia with gatifloxacin [Tequin] – no longer manufactured
Drug interactions: CYP450 inhibitor [cipro to greatest extent], antacids, iron
Not to be used in children < 18 yo
Have been used in patients with cystic fibrosis without sequelae