The EWI-2/alpha-actinin complex is involved in regulation of the actin cytoskeleton at T cell immune and virological synapses, providing a link between membrane microdomains and the formation of polarized membrane structures involved in T cell recognition.

analysis of interacting regions of CD81 (show CD81 Antibodies) and two of its partners, EWI-2 and EWI-2wint, and their effect on hepatitis C virus infection

This study showed that the EWI2 cytoplasmic tail actively engages with the cell membrane via phosphatidylinositol phosphate binding and palmitoylation.

Igsf8 is first expressed at E9.5 in a ventral domain of the neural tube, with dorsal expression apparent at E10.5.. From E11.5, Igsf8 occurs at the edge of the ventricular zone, in postmitotic neuroblasts, and in sensory ganglia.

Report that the expression level of EWI-2 on the Cd9 (show CD9 Antibodies)(-/-) oocyte surface is <10% of the wild-type level. Hence, the severe reduction in EWI-2 activity may be responsible for the loss of fusion ability.

IGSF8 Antigen Profile

Protein Summary

This gene encodes a member the EWI subfamily of the immunoglobulin protein superfamily. Members of this family contain a single transmembrane domain, an EWI (Glu-Trp-Ile)-motif and a variable number of immunoglobulin domains. This protein interacts with the tetraspanins CD81 and CD9 and may regulate their role in certain cellular functions including cell migration and viral infection. The encoded protein may also function as a tumor suppressor by inhibiting the proliferation of certain cancers. Alternate splicing results in multiple transcript variants that encode the same protein.