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According to the Mayo Clinic, symptoms of PMS include pain, mood swings and acne. Although it is unclear what causes PMS, hormone changes before ovulation may play a part. Stress and exercise habits may also contribute to more severe and longer-lasting PMS symptoms. The Mayo Clinic explains that PMS is treated with over-the-counter pain medicine, oral contraceptives or an injection of Depo-Provera to stop ovulation. PMS may also be treated with anti-depressants.