Phentermine is an appetite suppressant used along with diet, exercise, and behavior therapy for the short-term management of obesity. Some medicines or medical conditions may interact with this medicine. INFORM YOUR DOCTOR OR PHARMACIST of all prescription and over-the-counter medicine that you are taking. DO NOT USE THIS MEDICINE if you are also taking guanadrel, guanethidine, furazolidone, fenfluramine, dexfenfluramine, or monoamine oxidase inhibitors (MAOIs).

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Phentermine is an amine anorectic agent, which was initially introduced in the year 1959, as part of anti-obesity combination medicine. It is chemically associated to amphetamine and is commonly known as atypical amphetamine. The medicine has actually not been accounted for addictive potential that allows this drug to be categorized under Schedule IV medications (low abuse potential).

It has been approved by the U.S. Food and Drug Administration (FDA) for short term management and control of excess weight. It became extensively used in the year 1960. This initial combination drug, formed by dexfenfluramine and fenfluramine was discontinued after many reports of abnormal or unusual valves in about 30 percent of the customers. Afterwards, phentermine was approved solely and in effective combination with topiramate in the year 2012 as a new option, which required lower phentermine doses to obtain the sought-after effect.

Indication:

The medicine is indicated, in combination or alone with topiramate, as short term auxiliary, not exceed a few weeks, in regime of weight reduction established on caloric restriction, behavioral modifications and exercise in management of exogenic obesity for people with initial body mass index higher than 27 kg/m2 or higher than 30 kg/m2 in presence of risk factors like hyperlipidemia, diabetes, or controller hypertension.

Exogenous obesity is believed when overweight is actually caused by eating more food than an individual activity level warrants. Commonly, this condition causes increase in overall fat storage. In the U.S., obesity is considered to be an epidemic condition, where more than two-thirds of people are in fact obese or overweight, and 1 in 3 Americans is obese. Moreover, the relative incidence of obesity has almost doubled in the world.

Pharmacodynamics:

It has been reported that the primary mechanism of phentermine is appetite suppression, perhaps due to increase in leptin; however it is thought that other mechanisms must be involved. Some medical reports have pointed that weight loss effect is primarily due to an augmentation in resting energy usage.

In clinical examinations where phentermine was utilized as a combination therapy or monotherapy, this medicine has demonstrated a mean weight loss of 3.5kg when equated with placebo in 3-24 weeks. Individuals treated with this medication also exhibited increased weight maintenance even after discontinuation of treatment. Though, this drug is derivative of amphetamines, it does not produce effects of amphetamine like QTc prolongation, tachyphylaxis, increased blood pressure or central nervous system stimulus.

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