Objective: To describe in a case series the chiropractic care of two children with Asperger’s Syndrome suffering from long-term nocturnal enuresis.

Clinical Features: A 10-year old male, diagnosed with Asperger’s at 6 years of age, presented for care for neck pain following a fall from a trampoline. Additionally, the patient suffered from nocturnal enuresis nightly since age 2 years. Notable examination findings from static and motion palpation revealed subluxations at the C4, T1-T4 vertebral body and the right sacro-iliac joint. The second patient was a 9-year-old male also diagnosed with Asperger’s Syndrome with nocturnal enuresis every night since age 5 years. Subluxations were detected at the C5 and T6 vertebral body with the sacrum restricted anterior.

Intervention and Outcome: The 10-year-old was cared for with Diversified Technique resulting in cessation of bedwetting following the first visit. The 9-year-old was cared for with Diversified Technique for 9 visits with minor improvements in bedwetting. On the 10th visit, Logan Basic was utilized resulting in cessation of bedwetting. On long-term follow-up, both patients continued to be free from nocturnal enuresis.

Conclusion: This case series provides supporting evidence on the effectiveness of chiropractic care in patients suffering from nocturnal enuresis.