One of the most crowded and popular to both local people and tourists is MBK Center (also known as Mah Boon Krong). It is packed with shops offering fashion items, mobile phones and souvenirs. A covered, air-conditioned pedestrian bridge over Phaya Thai Road connects to a congested sister shopping center, the Bonanza Mall, which mostly sells inexpensive clothing and fashion accessories.

Siam Square, unlike others, is a shopping area consists of a block of buildings and lots of small roads full of shops, attracting mostly teenagers. There are two cinemas in Siam Square, built in the 1970s and run by the Apex chain: the Scala theater offer a single, big screen; the Lido is a small multi-plex with three screens. Another single big screen theater built in the same era, Siam, was destroyed during the 2010 Thai military crackdown. Besides shops, many exam preparation schools are found in Siam Square. So the area is full of students during evening and weekends.

A large portion of Pathum Wan is occupied by several organizations. Near MBK, Chulalongkorn University is the oldest university in Thailand. The main auditorium together with Faculty of Arts buildings Maha Chulalongkorn and Maha Vajiravudh are famous architectures. The Museum of Imaging Technology within the Faculty of Science houses a large collection of cameras from old to new. Next to the university are Chulalongkorn Hospital and Thai Red Cross. Inside the Red Cross there is a snake farm called Queen Saovabha Memorial Institute (or Sathan Saovabha in Thai) showing venom extraction and producing serum to treat snakebites.

One of the major tourist attractions is the Jim Thompson House. It is a complex of magnificent Thai wooden houses formerly home to James H.W. Thompson, an American who lived in Thailand, developed Thai silk industry, and brought it to fame to the western world. Now it is turned into a museum filled with lots of antique decorations.

The Erawan Shrine at the Ratchaprasong intersection is a sacred place where people come to pray and make wishes to Brahma. Wishes could include getting admitted to university, babies, jobs, and so on. Flowers, wooden elephants, or traditional Thai dances are returned when a wish is granted. The Trimurti shrine and Ganesha shrine at CentralWorld are popular places to pray as well.

Every year around Christmas and New Year, shopping centers, hotels and sidewalks in the Ratchaprasong shopping district are heavily decorated with lights celebrating the event. It was started by Peninsular Plaza and The Regent hotel, and later expanded to Sogo (now out of business), Amarin Plaza, CentralWorld, Central Chit Lom, Gaysorn and more. Bangkok Metropolitan Administration also provides lights along the BTS Skytrain pillars. During the period, it is the brightest lit area of Bangkok. The countdown is held on the ground in front of CentralWorld.