first direct evidence in humans that alprazolam (Xanax) acutely increases perfusion in the nucleus accumbens, a key reward-processing region linked to addiction.

As a whole, the nucleus accumbens has a significant role in the cognitive processing of motivation, aversion, reward (i.e., incentive salience, pleasure, and positive reinforcement), and reinforcement learning

Benzodiazepines’ newly discovered mechanism for producing reward is comparable to those of opiates, cannabinoids, and GHB.

The road to addiction deals with structural changes in the brain as the continued use of benzos start to change the structure of the brain to respond more strongly to future

These receptors render the cell more susceptible to stimulation by the excitatory neurotransmitter glutamate, and as a result, the cells respond to future drug exposures with larger dopamine surges that produce even more intense pleasure.

Furthermore...their assessment after watching structural changes in the dopamine neurons:

Even if you clear the drug from the body, there are long-lasting changes in brain architecture.”

Xanax causes addiction in much the same way that other drugs, including opiates like oxycodone, cause addiction

It's half-life is roughly 6-29 hours. Peak levels are usually in 1-2 hours and it's cleared primarily by the kidney.

Xanax has one of the shortest durations of any of the benzos and has no metabolites so lessen the drop off.

This might be why it has a street value and a slew of nicknames on the streets.

There's even a rapper called Lil Xan and it punctuates a great deal of the soundcloud rap scene despite being involved in the death of many prominent entertainers.

Last we check, there was no rapper called Lil Oxy.

CBD's peak level is from 4-6 hours and generally lasts about 24 hours in the body.

More importantly, CBD doesn't cause the rush of dopamine associated with Xanax.

Studies have shown that it not habit forming or hedonic.

Hedonic is the key there.

It's a scientific word that means pleasure causing. Remember the dopamine rush centers were tied to pleasure and behavior reinforcement for Xanax and other benzos.

CBD studies have shown it to be:

Non-hedonic

Non habit forming

Not subject to normalization (need more and more for same effect)

Not psychoactive

These are the key differences between CBD and Xanax.

In 2013…

national ED visit data and national prescription data show that alprazolam is related to more ED visits related to drug misuse per prescription (1 in 311) than the next 3 most commonly prescribed benzodiazepines—lorazepam (1 in 540), diazepam (1 in 517), and clonazepam (1 in 321)

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