Slovenija (Eurovetgene)
The product of MDR1 gene is a protein responsible for transport of different substances across cell membrane. It is found in membranes of intestinal epithelial cells, proximal kidney tubules and liver hepatocytes. The action of this protein is connected to removal of certain molecules out of an
organism through urine and bile. The protein is also found on a blood-brain boundary and is responsible for restriction of entry of such molecules into central nervous system. A mutation in MDR1 gene causes the production of non-functional protein which in turn causes sensitivity on certain drugs,
especially ivermectin.

Mutation et classification / Mutation and classification

(+/+)

Non carrier

Normal

Normal/Normal

(+/-)

Carrier

Carrier

Normal/Mutant

(-/-)

Affected

Affected

Mutant/Mutant

Total MDR1: 7236

MDR1 (+/+): 2096 (29%)

MDR1 (+/-): 3496 (48.3%)

MDR1 (-/-): 1644 (22.7%)

DM: Degenerative Myelopathy / Myélopathie Dégénérative du chien âgé.

USA: (OFFA)
Mutation in a gene which is associated with development of degenerative myelopathy (DM). In that gene, the DNA occurs in two possible forms (or alleles).
The G allele is the predominant form in dogs that seldom or never develop DM; you can think of it as the Good allele.
The A allele is more frequent in dogs exhibiting clinical signs of DM; you can think of it as the Affected allele.

USA (Optigen)
Collies share Collie Eye Anomaly (CEA) with several other breeds  its not just a problem for collies. CEA is more technically known as Choroidal Hypoplasia (CH). It is a recessively inherited eye disorder that causes abnormal development of the choroid - an important layer of tissue under the retina of the eye. This disease is seen most frequently in U.S. collies, but
also worldwide in Rough and Smooth Collies, Border Collies, Australian Shepherds, Lancashire Heelers, and Shetland Sheepdogs. Since the choroid layer does not develop normally from the start, the primary abnormality can be diagnosed at a very young age. Regrettably, there is no treatment or cure for CEA.

Czech Rep (Genomia)
This specific form of PRA-rcd2 (rod-cone dysplasia) affects collies (long-haired and short-haired). If the dog is affected by rcd2 disease, abnormal development (dysplasia) of rods and cones (photoreceptors) occurs. The development of photoreceptors is stopped and is followed by their fast degeneration.
Both types of photoreceptors degenerate, while the rod degeneration is much faster than the cone degeneration and therefore, the night blindness occurs as first. Dysplasia results in night blindness by 6-week-old puppies. In affected puppies, the rod and cone cells gradually lose their normal function
in outer segments of the affected retina (Santos-Anderson et al. 1980).

USA (dogenes)
Renal dysplasia (RD) is an important category of kidney diseases in canines. Dysplasia is defined as abnormal growth or development of cells or organs. In the case of RD the kidney fails to develop properly during embryogenesis in the womb. At birth immature structures consisting of undifferentiated fetal cells or tissue types are found in the kidney, and are persistent
throughout the life of the animal.
More: http://www.vetprof.com/clientinfo/juvenilerenal.html