Dianemycin (Nanchangmycin) can be used as a growth promotant in poultry and to cure coccidiosis in chickens. Dianemycin is active against drug resistant strains of malaria[1].
Dianemycin (Nanchangmycin) as a potent inhibitor of Zika virus (ZIKV) entry across all cell types tested including physiologically relevant primary cells. Dianemycin potently reduces infection of all three strains of ZIKV across all three cell types. The IC50s for infection are between 0.1 and 0.4 μM while Dianemycin has low toxicity in these ranges. In addition, DENV is inhibited by Dianemycin across cell types[2].

Solvent & Solubility

In Vitro:

DMSO : 155 mg/mL (178.75 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing Stock Solutions

ConcentrationSolventMass

1 mg

5 mg

10 mg

1 mM

1.1533 mL

5.7663 mL

11.5326 mL

5 mM

0.2307 mL

1.1533 mL

2.3065 mL

10 mM

0.1153 mL

0.5766 mL

1.1533 mL

*Please refer to the solubility information to select the appropriate solvent.