CancerWe are studying the role of bone marrow stroma in the
development and progression of hematologic malignancies and other
cancers. Recent evidences show that the bone marrow stroma through
direct cell-cell contact and/or secreted factors contribute to
cancer development, progression and chemo-resistance.

Cell
TherapyIt has been
known that adult-marrow-derived mesenchymal stem cells (MSC) has
tremendous potential to differentiate into bone, cartilage, muscle,
marrow stroma, tendon-ligament, fat and other connective tissues.
The use of stem cells has been limited due to requirement of large
number of cells for therapy as most of these cells disappear shortly
after transplantation. Therefore we are trying to understand their
in vivo survival/death mechanisms that might help to improve the
efficacy of these cells for therapy.

Stem Cells
Our lab is interested in studying
Mesenchymal Stem Cells (MSC), which are adult multipotent cells from bone marrow and
other connective tissue. MSC have got the capacity to differentiate into mesenchymal tissue cells
such as adipocytes, osteocytes, chondrocytes and muscle cells. Our
special focus is on the biology, differentiation potential, aging, cytoskeleton
and migration of MSC.