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Re: New downer? Just wondering if this new drug has any recreational value.

Well thanks for clarifying this, swim thanks you. However I dont think it is being advertised as a sleeping pill. It is for "restless leg syndrome" and/or parkinsons disease. But that is neither here nor there, you answered my question and therefore I have concluded this drug has no recreational value at all. Thanks again

Re: New downer? Just wondering if this new drug has any recreational value.

thanks for that. I know i sound stupid, but I am a newbie. I am not a newbie in the sense that he is not an experienced drug user. I am very experienced. My only question was if this had recreational value, not if the pill was a sleeping pill. Thanks for the input anyways

Re: New downer? Just wondering if this new drug has any recreational value.

It's too new for many reports regards it's abuse-potential, but the drug company would likely keep such quiet if possible. They're spending millions on TV ads. If a monkey were to find out, give it a banana to write a report.

Re: New downer? Just wondering if this new drug has any recreational value.

Dopamine agonists do have potential recreational uses (and it also has opiate receptor affinity, very interesting), but until someone experiments it's only a theory. If it's unscheduled, chances are whatever recreational value it has will not be terribly high.

An acute dystonic reaction consists of sustained, often painful muscular spasms, producing twisting abnormal postures. 50% occur within 48 hours of initiation of the neuroleptic. 90% occur within 5* days. These reactions are more common with parental then oral medications. They're more common in the younger patients, and more common in males than females in the young age group.

Approximately 3 to 10% of patients exposed to neuroleptics will experience an acute dystonic reaction. Haldol and the long acting. injected fluphenazines have the highest incidence of these reactions.* The risk is higher in patients with a prior history of a similar reaction or a family history of dystonia. The order of the most frequent types include neck dystonia 30%, tongue dystonia 17%, jaw dystonia 15%,* oculorgyric crisis (eyes rolling back, and neck arching) 6%, and opisthotonus (body arching) 3.5%. The movements than may fluctuate over hours and temporarily abate in response to reassurance. This can* cause an inappropriate diagnosis of hysteria. They typically last minutes to hours without treatment. Occasionally the movements are more choreiform. They are more typically generalized in young patients* and more focal in the older patients.

Pathophysiology

The pathophysiology of acute dystonic reaction secondary to* neuroleptics remains unknown. The movements typically occur at a time when the blood level of medication is dropping.* Patients with liver dysfunction are more prone to these reactions. There is a higher* incidence in patients with a prior history of a similar reaction or family history of dystonia.

Treatment

The treatment is to discontinue the offending agent. Intr-muscular anticholinergics (e.g. Benztropine 2 mg IV) should be used and should be continued orally for 24 - 48 hours depending on the ½ life of the* neuroleptic used. If the neuroleptic treatment is to be continued, usually the anticholinergic can be safely tapered over 2 - 3 weeks. Some evidence suggests that long-term concomitant anticholinergics may* predispose to tardive dyskinesia.

Amantadine is a preferred treatment option by some due to a better side effect profile. Routine prophylaxis with these medications would* be appropriate in patients with a previous proven risk for dystonic reactions.

Re: New downer? Just wondering if this new drug has any recreational value.

I always found it amusing methylphenidate has "may cause drowsiness" as a warning label.

Having never tried it I always assumed it was stimulating( Da Reuptake I). Anyone know if it is certain Dopamine receptors which (can) cause drowsiness or a general affect that sometimes occurs with Dopaminergics?

I always found it amusing methylphenidate has "may cause drowsiness" as a warning label.

Having never tried it I always assumed it was stimulating( Da Reuptake I). Anyone know if it is certain Dopamine receptors which (can) cause drowsiness or a general affect that sometimes occurs with Dopaminergics?

Re: New downer? Just wondering if this new drug has any recreational value.

Ritalin and amphetamines are SUPPOSED to make people with ADD & ADHD calm and mellow. "Normal" people are the ones it gives a boost in energy levels to. Kid I knew was given Seconal to wake him up, and Ritalin to knock him out in school. Instead it just fucked him up so badly that he never learned how to read or write. When his mother complained to the school-board, they threatened to have the kid committed to a state mental hospital if she didn't shut up about their utter failure.

Ritalin and amphetamines are SUPPOSED to make people with ADD & ADHD calm and mellow. "Normal" people are the ones it gives a boost in energy levels to. Kid I knew was given Seconal to wake him up, and Ritalin to knock him out in school. Instead it just fucked him up so badly that he never learned how to read or write. When his mother complained to the school-board, they threatened to have the kid committed to a state mental hospital if she didn't shut up about their utter failure.

Click to expand...

Do kids/adults with ADD find benzos/barbs wake them up?(in general) ^Its very sad when psychoactivedrugs mess a child up.

Interesting to say the least... Baboon could only feel his core beginning from the abdomen up.
Not necessarily in a good way, however. At times, Baboon indicated that it felt like his limbs had completely disappeared.

Baboon just now upon me finding the above picture realized it was prescribed in quite a higher dose than he had thought. .5 mg insufflated had a pretty pronounced effect. He says he can't even imagine insufflating 3, let alone 5 mgs!

I don't give a fuck what anyone says, but that stuff is like 5 drugs in one. The main actions are dopamine and opioid agonist. It also has SOME (notice it says negligible, not none) affinity for a shitload of other receptors that get you high, including 5-HT2 (acid anyone?). Just try a few of those man.

This drug directly affects the dopamine system. And it may trigger the opioid receptors. The real question is, considering the beauty of it on paper, is why the hell aren't people scrambling to try this thing out? Could be the sleepiness (requip doesn't affect D1 receptors, the stimulating ones) that deters people from it, or it could just be a general lack of euphoric properties.

SwiPA has ready access to these and will start trying them in oral and insufflated doses. A thread with his reports will be made as soon as the first trial is completed.

EDIT: This drug may benefit from combination with another substance that has effects on the D1 receptors. That combo also might be very bad for an unfortunate lab rat's health. There could be an alcohol/benzo type reaction here, in that small doses of both synergize nicely, but anything over the threshold dose is hazardous.