Two men are found murdered at Garou's Landing, a small outpost in the snow-covered Canadian Northwest. Sergeant Renfrew, assigned to the case, journeys north to bring back the murderer, dead or alive.

Second of the eight Renfrew films, James Newill reprises his role as the stout-hearted musical Mountie. On the Great White Trail is an intriguing murder mystery. The story's whodunit angle is well handled with a surprising twist that provides the impetus for the film's climax.