RESEARCH -
Since 1999, we have been uncovering new modes of reactivity and applying these discoveries in chemistry to the development of fundamentally new concepts in enantioselective catalysis and basic reaction development. Complex natural product total synthesis is the beginning and end of the project development cycle, and we have more recently succeeded in applying our discoveries to the de novo synthesis of therapeutics. These pages summarize some accomplishments across the areas of target synthesis, therapeutic development, and enantioselective catalysis. With several colleagues in biochemistry, cancer biology, and drug development, we collaboratively advance the discipline of chemical biology to leverage the power of chemical synthesis, thereby clarifying our basic understanding of the pathology and treatment of disease.