Louisville running back Brandon Radcliff (23) attempts to break a tackle by Wake Forest safety Anthony Wooding, Jr. (11) but continues to complete a 29-yard scoring play in the first half of their NCAA college football game in Louisville, Ky., Saturday, Sept. 27, 2014. (AP Photo/Garry Jones)
(The Associated Press)

Louisville running back Michael Dyer (5) runs through a big hole in the Wake Forest defensive line in the first half of their NCAA college football game in Louisville, Ky., Saturday, Sept. 27, 2014. (AP Photo/Garry Jones)
(The Associated Press)

Louisville quarterback Reggie Bonnafon (7) attempts to break a tackle by Wake Forest linebacker Marquel Lee (8) on a run in the first half of their NCAA college football game in Louisville, Ky., Saturday, Sept. 27, 2014. (AP Photo/Garry Jones)
(The Associated Press)

Brandon Radcliff ran for two touchdowns and 129 yards and the Louisville defense held firm in Saturday's ugly 20-10 win over Wake Forest.

Listed fourth on the depth chart, Radcliff's first career 100-yard effort on 17 carries was much needed as Louisville (4-1, 2-1 ACC) overcame three lost fumbles and 11 penalties. The Cardinals defense kept Wake Forest (2-3, 0-1) to minus-22 yards rushing and had three takeaways, both setting up touchdowns. Louisville also had eight sacks.

Wake Forest scored first on Mike Weaver's 43-yard field goal late in the first quarter and retook the lead at 10-7 with 8:32 remaining in the third quarter following nose tackle Tylor Harris's fumble recovery in the Louisville end zone for a touchdown.

Radcliff's 16-yard score with less than 12 minutes left followed his 29-yard second-quarter touchdown.