East of Lyons is an intersection with SR 86. Just past SR 86, the route crosses the Ohoopee River, where it enters Tattnall County. Farther to the southeast, in the city of Collins, is an intersection with SR 23/SR 57/SR 121. The route continues east through Manassas and enters the city of Bellville. There, it intersects SR 169. Just east of Bellville, SR 292 meets its eastern terminus, an intersection with US 280/SR 30.