A study of 84 cases of patients with Hepatitis A and E Virus has been presented with special reference to epidemiological aspects. A Prospective study was conducted in patients with acute Hepatitis in Hepatitis A and E virus. The Hepatitis A virus is found majorly in Males whereas Hepatitis E virus is found more in Females. The incidence of Hepatitis A and E Virus was progressively higher with age group 21-30 years and lowest occurring in 0-10 and 61-70 years. Patients most commonly presented with hepatomegaly, malaise, yellow discoloration of eyeballs. Enterically transmitted hepatitis A and E infections is seen in throughout the world in developed as well as developing countries. Sanitation and standard of living conditions determine its incidence. The present study aimed to find out the acute hepatitis A and hepatitis E infections in patients with acute viral hepatitis.