a good quick read on Agmatine

Agmatine [4-(aminobutyl)guanidine], an endogenous neurotransmitter [1], is decarboxylated L-arginine and is a metabolic product of mammalian cells. Agmatine binds to α2-adrenergic receptor, it induces the release of some peptide hormones, and was reported to inhibit nitric oxide synthase (nitric oxide synthases are responsible for the production of nitric oxide from L-arginine) [1,2].Agmatine benefits for exercise

There are many claimed benefits of agmatine and a lot of disinformation is circling all over internet. Some even claim that agmatine increases nitric oxide production via inhibition of nitric oxide synthase enzyme, which is nonsense. A study by Elena Galea and others [2] reported that agmatine is a competitive inhibitor of all nitric oxide synthase isoenzymes. However, it seems that agmatine stimulates some types of nitric oxide synthase while inhibiting others. Morrissey and Klahr [3] reported that agmatine caused activation of nitric oxide synthase in endothelial cells (layer of cells on inner surface of blood vessels). Agmatine appears to act directly on endothelial cells to increase the synthesis of nitric oxide, which induces them to cause vasodilatation [3].
Agmatine has potential to treat chronic pain, addictive states and brain injury due to its ability to inhibit hyperalgesia (increased sensitivity to pain) and its neuroprotective activity [4]. Therefore it may potentiate the effects of analgesics used during recovery from injury. Feyza Aricioglu and Hale Altunbas [5] reported modulatory effect of agmatine on anxiety and depression. Accumulating evidence suggests that agmatine possesses nootropic effects and that is a novel neurotransmitter [6]. More and more evidence is accumulating on the involvement of agmatine in the processes of learning and memory, however, direct evidence of its involvement is currently lacking [6].In vitro studies are also showing insulin-like effect [7]. Sener A. et al. [8] have shown that agmatine causes stimulation of insulin secretion but fails to affect insulin release in the absence of glucose.

Agmatine [4-(aminobutyl)guanidine], an endogenous neurotransmitter [1], is decarboxylated L-arginine and is a metabolic product of mammalian cells. Agmatine binds to α2-adrenergic receptor, it induces the release of some peptide hormones, and was reported to inhibit nitric oxide synthase (nitric oxide synthases are responsible for the production of nitric oxide from L-arginine) [1,2].Agmatine benefits for exercise

There are many claimed benefits of agmatine and a lot of disinformation is circling all over internet. Some even claim that agmatine increases nitric oxide production via inhibition of nitric oxide synthase enzyme, which is nonsense. A study by Elena Galea and others [2] reported that agmatine is a competitive inhibitor of all nitric oxide synthase isoenzymes. However, it seems that agmatine stimulates some types of nitric oxide synthase while inhibiting others. Morrissey and Klahr [3] reported that agmatine caused activation of nitric oxide synthase in endothelial cells (layer of cells on inner surface of blood vessels). Agmatine appears to act directly on endothelial cells to increase the synthesis of nitric oxide, which induces them to cause vasodilatation [3].
Agmatine has potential to treat chronic pain, addictive states and brain injury due to its ability to inhibit hyperalgesia (increased sensitivity to pain) and its neuroprotective activity [4]. Therefore it may potentiate the effects of analgesics used during recovery from injury. Feyza Aricioglu and Hale Altunbas [5] reported modulatory effect of agmatine on anxiety and depression. Accumulating evidence suggests that agmatine possesses nootropic effects and that is a novel neurotransmitter [6]. More and more evidence is accumulating on the involvement of agmatine in the processes of learning and memory, however, direct evidence of its involvement is currently lacking [6].In vitro studies are also showing insulin-like effect [7]. Sener A. et al. [8] have shown that agmatine causes stimulation of insulin secretion but fails to affect insulin release in the absence of glucose.

In my research last evening (on the web, lol) I came across a site that gave a lot of pro's and con's on Agmatine. It was a very positive article with links to a lot of research that has been done in different studies, etc. However, one con they mentioned twice was that Agmatine has the capability to negate the blocking properties of Yohimbe.

Is this something that is well known or not a major deal. I'm going to continue using the Agmatine but I just had that question. Thanks,

In my research last evening (on the web, lol) I came across a site that gave a lot of pro's and con's on Agmatine. It was a very positive article with links to a lot of research that has been done in different studies, etc. However, one con they mentioned twice was that Agmatine has the capability to negate the blocking properties of Yohimbe.

Is this something that is well known or not a major deal. I'm going to continue using the Agmatine but I just had that question. Thanks,

I've never heard of this and I happen to be using Agmatine and Yohimbine HCL at the moment... In for more info

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