Trained technicians or medical doctors usually use
visual determinations to place magnetic resonance
spectroscopy (MRS) voxels over multiple scan sessions in
longitudinal studies. However, manual voxel prescription
extends the scan time and causes variability of voxel
placement. In this study, a vendor-provided automatic
voxel positioning technique was for the first time
applied to prescribe MRS voxels for longitudinal studies
at 7T. Through prescribing voxels on two regions of ten
subjects, accurate voxel prescription (mean voxel
overlap ratio 0.910.06 across scans and regions over
subjects) and high reproducibility with intraclass-correlation-coefficient
0.88 between regions across scans and subjects validate
this technique.

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