COMPASS: Combinatorial Polyfunctionality Analysis of Single Cells

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COMPASS is a statistical framework that enables unbiased analysis
of antigen-specific T-cell subsets. COMPASS uses a Bayesian hierarchical
framework to model all observed cell-subsets and select the most likely
to be antigen-specific while regularizing the small cell counts that often
arise in multi-parameter space. The model provides a posterior probability
of specificity for each cell subset and each sample, which can be used to
profile a subject's immune response to external stimuli such as infection
or vaccination.