This study will treat approximately 24 participants who experience cold sores. Patches will be applied to the cold sore for up to ten days, and the symptoms will be measured during daily clinic visits using non-invasive measurement techniques.

Mean Change From Baseline in Blood Flow [ Time Frame: Baseline to Day 10 ] [ Designated as safety issue: No ]

Measurement of blood flow was performed using Field Laser Perfusion Imaging (FLPI) technique.

Total episode value (TEV) was calculated as the summation of (test region response minus control region response) across all days. Maximum episode value (MEV) was calculated as the maximum of (test region response minus control region response) across all days.

Mean Change From Baseline in Temperature [ Time Frame: Baseline to Day 10 ] [ Designated as safety issue: No ]

Lesion thermographic parameters for TEV and MEV were analysed.

Mean Change From Baseline in Color Intensity of Lesions [ Time Frame: Baseline to Day 10 ] [ Designated as safety issue: No ]

The redness of the cold sores to be measured and quantified using sophisticated, standardized and reproducible color photography. Parameter represents distance between test and control values according to a* axis and b* axis colour intensity values. The values on the scale ranged from -100 (green, lowest intensity) to +100 (red, highest intensity).

Secondary Outcome Measures:

Participant Assessment of Patch Comfort and Noticeability at Day 5 [ Time Frame: Day 5 ] [ Designated as safety issue: No ]

Participants who are susceptible to cold sores that reactivate when exposed to ultraviolet (UV) light

Contacts and Locations

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To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below.
For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01653509