This is a preliminary study to determine the safety and efficacy of intravenous immune globulin in treating Spinocerebellar Ataxia. The investigators aim to assess changes in clinical measures of disease severity before and after treatment.

Stable doses of all medications for 30 days prior to study entry and for the duration of the study.

Stable doses of all antidepressants and vitamins (including internet purchased idebenone) for 30 days prior to study entry and for the duration of the study. Throughout the study, all possible efforts should be made to maintain stable doses of all other medications.

Subject permission (informed consent).

Exclusion Criteria:

Any unstable illness that in the investigator's opinion precludes participation in this study.

Use of any investigational product within the past 30 days.

Presence of clinically significant cardiac disease (as determined by the investigator based on EKG and echocardiogram results within the past 6 months). Specifically, an ejection fraction <40%, or a prolonged QT interval (>50% of cycle duration) will be excluded. If the investigator notes clinically significant abnormalities on the EKG or echocardiogram, the subject will be eligible IF they provide clearance from a cardiologist.

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study.
To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below.
For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01350440

Locations

United States, Florida

University of South Florida

Tampa, Florida, United States, 33612

Sponsors and Collaborators

University of South Florida

Baxter Healthcare Corporation

Investigators

Principal Investigator:

Theresa Zesiewicz, MD

University of South Florida

More Information

Responsible Party:

Theresa Zesiewicz, Professor of Neurology, University of South Florida