Researchers from Boston University School of Medicine (BUSM) found that among all hospitalizations that were due to firearm injury, patients who underwent surgical repair of their major blood vessels had the highest injury severity score (predictor of in-hospital death). One out of 10 patients hospitalized with a firearm injury will need to undergo vascular surgery […]

When DNA in the cell nucleus gets damaged, our cells can resort to a variety of repair mechanisms. A recent study published in ‘Nature Cell Biology‘, to which scientists from Helmholtz Zentrum Muenchen made major contributions, elucidates the molecular basis by which a cell makes the choice between these repair mechanisms. The trick the scientists […]

The placenta offers an abundant source of placenta-derived mesenchymal stem cells (pMSCs), which a new study has shown can readily form cell sheets that could be implanted in children with congenital heart defects and offer benefits for heart repair and regeneration compared to commonly used synthetic material-based scaffolds. Congenital heart disease is the leading cause […]

A team of researchers led by Jonathan Stamler, MD, of Case Western Reserve University School of Medicine and University Hospitals Cleveland Medical Center, has discovered a pathway for enhancing the self-repair efforts of injured kidneys. The finding may pave the way for new drugs to stop or even reverse the progression of serious kidney disease […]

Houston Methodist researchers have discovered a repair defect in nerve cells that send messages to the brain, opening the door to a possible therapy for preventing or slowing down ALS. Also known as Lou Gehrig’s disease, ALS is a terminal illness marked by rapidly progressive muscle weakness that ultimately affects a person’s ability to swallow […]

According to data from the Centers for Disease Control and Prevention, nearly half of U.S. adults have gum disease. Harmful plaque bacteria can hide in crevices below the gum line. When left untreated, the plaque bacteria can break down enamel and cause permanent damage. New Crest Gum & Enamel Repair™, a specially designed paste, focuses […]

Researchers from Tokyo Metropolitan University and the FIRC Institute of Molecular Oncology (IFOM) in Italy have uncovered a previously unknown function of the DDX11 helicase enzyme. Mutations in the gene which codes for DDX11 are known to be implicated in Warsaw Breakage Syndrome. They showed that DDX11 plays an important role in DNA repair, and […]

In a new study, researchers from the University of Copenhagen have identified one of the main mechanisms behind the repair of serious damage to the human DNA. A ‘scanner’ inside the cells decides whether or not so-called flawless DNA repair, which protects against cancer, is launched. Damage to the human DNA can cause unstable genetic […]

A team of researchers led by Jonathan Stamler, MD, of Case Western Reserve University School of Medicine and University Hospitals Cleveland Medical Center, has discovered a pathway for enhancing the self-repair efforts of injured kidneys. The finding may pave the way for new drugs to stop or even reverse the progression of serious kidney disease […]

From January 1, 2019, the German Research Foundation (DFG) will be funding the new Collaborative Research Center (CRC) 1361 on Regulation of DNA Repair & Genome Stability. Professor Helle Ulrich of Johannes Gutenberg University Mainz (JGU) will assume the role of spokesperson of the group, which will also include the Institute of Molecular Biology gGmbH […]

Researchers at the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) have established the trigger for catastrophic events that occur within the chromosomes of cancer cells. Novikov Aleksey | Shutterstock They found that failure of DNA repair systems promotes fragmentation and disrupted assembly of chromosomes. However, the researchers say these DNA repair defects could potentially be […]

THURSDAY, Sept. 20, 2018 — Preoperative statin therapy is associated with higher long-term survival following abdominal aortic aneurysm (AAA) repair, according to a study published in the August issue of the Journal of Vascular Surgery. Thomas F.X. O’Donnell, M.D., from the Beth Israel Deaconess Medical Center in Boston, and colleagues used data from the Vascular […]

Lack of dysferlin is associated with increased lipid mobility in the limb girdle muscular dystrophy type 2B (LGMD2B) cell membrane, which is further increased by injury and prednisolone treatment, causing failure of these cells to undergo repair. By contrast, vamorolone treatment stabilizes the LGMD2B muscle cell membrane to near healthy cell level, enabling repair of […]

Aug 24 2018 Through a study of roundworm nerve cells with severed axons, researchers at Nagoya University showed that a signaling cascade that normally functions in promoting the phagocytosis of apoptotic cells also acts in inducing axon regeneration. The findings shed light on a fundamental feature of nerve repair, which is limited in the central […]