In the sixties and seventies, a TV series based on Radioactive Man was shown, notable for being more camp than previous portrayals. It also starred Dirk Richter. One of the villains in this series was The Scoutmaster. A film based on it was released in 1967.

In the 1980s, Troy McClure starred as Radioactive Man in a film trilogy, consisting of:

A Hollywood studio attempted to film a Radioactive Man movie in Springfield. The movie starred Rainier Wolfcastle as Radioactive Man. The role of Fallout Boy was cast from local children. It went to Milhouse Van Houten. Krusty the Clown was cast as villains Dr. Clownius and Silly Sailor. Wolfcastle was incapable of saying the "Up and Atom!" catchphrase correctly, pronouncing it "Up and at zem," on account of his German accent. The movie was never completed due to budget overruns caused by constant price-gouging by Springfield vendors, and Milhouse snapping from the pressure of the role, and refusing to continue to portray Fallout Boy - former child actor Mickey Rooney attempted to take over the role, but the film was shelved.[3]

Although it varies slightly in different comics, when millionaire layabout playboy Claude Kane III was caught up in a nuclear explosion, he gained super powers and became Radioactive Man. The explosion lodged a lightning bolt-shaped piece of metal in his head, which helped him survive.

In Radioactive Man #72, he marries one of his enemies, Larva Girl. However, this story is just an imaginary tale.
Radioactive Man died at the hands of The Fossil Fuel Four, but got rebooted in a new issue.