Summarized below are highlights from the new Norvir Tablet package insert.

Unlike the capsule formulation, Norvir tablets must be taken with meals. As a result, Section 2 *DOSAGE AND ADMINISTRATION* contains the following information specific to the tablet formulation.

NORVIR is administered orally. NORVIR tablets should be swallowed whole, and not chewed, broken or crushed.

General Dosing Guidelines

Patients who take the 600 mg twice daily soft gel capsule NORVIR dose may experience more gastrointestinal side effects such as nausea, vomiting, abdominal pain or diarrhea when switching from the soft gel capsule to the tablet formulation because of greater maximum plasma concentration (Cmax) achieved with the tablet formulation relative to the soft gel capsule "[see Clinical Pharmacology (12.3)]". Patients should also be aware that these adverse events (gastrointestinal or paresthesias) may diminish as therapy is continued.

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