lesion begins at bite site, then invades nearby mucocutaneous areas; may lead to destruction of mucous membrane of nose, mouth, throat

Geographic distribution of Cutaneous Leishmaniasis

Mediterranian, Equitorial Africa, Middle East, India, China

CM of cutaneous leishmaniasis

Small papule at bite site, will progress to a large ulcer, upon healing leaves a large scar

Pathogenesis of Leishmania

sandfly injects promastigote into skin, then these are phagocytized by macrophages, and tranformed into amastogotes in the phagolysosome(these are resistant to lysosomal enzyme, and grows in macrophage, then infected cell dies releases amastigote which infects other macrophages

Diagnosis of Leishmania

Serology, ID amastigote forms in tissue

Treatment of Leishmania

Antimony compounds(from the CDC)

Another parasitic flagellate that is found worldwide, causes diarrhea and malabosorption

Giardia lamblia

another parasitic flagellate that is found worldwide, is spread sexually and causes genital infections

Trichomonas vaginalis

another parasitic flagellate that is a blood parasite that causes African sleeping sickness

Trypanosoma brucei

What kind of organism are Schistosomes

Parasitic Trematode, aka..Fluke, 1cm, complex lifecycle

How may an adult be infected with Schistosomes?

What kind of diseases are associated with schistosomes

What is the intermediate host of schistosomes/

snails(freshwater usually)

Fasciola hepatica

liver fluke

CM of fasciola hepatica

chronic intermittent biliary obstruction and inflammation

Schistosoma sp.

blood fluke

CM of schistosoma sp.

abdominal pain, hepatosplenomegaly, bloody diarrhea

Paragonimus westerinani

oriental lung fluke

CM of Paragonimus westerinani

chronic cough, hemoptysis

S. haematobium

visible spine, urinary schistosomiasis

S. mansoni

visible spine, intestinal

S. japonicum

spine not visible, Asian intestinal schistosomiasis

Acute CM of Schistosomiasis

flu-like illness due to immune response bc of egg production

Chronic CM of Schistosomiasis

due to immune response to eggs, walling off lesion interferes with organ function