This study is being done to find out if breast cancer detection will be improved using a short MRI (magnetic resonance imaging) scan, in addition to mammography, in patients who are at an increased risk of developing breast cancer.

The primary aim of the study is to estimate the negative predictive value (NPV) of the abbreviated exam for screening purposes, using a full length diagnostic study for confirmation and one year follow-up exams. [ Time Frame: 2 years ]

Secondary Outcome Measures:

Secondary aim is to estimate the proportion of patients who go on to have a more comprehensive exam based on the results of the short exam. [ Time Frame: 2 years ]

High risk for the development of breast cancer. For the purposes of this study high risk women will be defined as those having one of the following:

One or more first degree blood relative(s), maternal or paternal, with known primary breast cancer, PLUS a Gail model calculated 5 year risk of greater than or equal to 1.67%

First, and/or second degree blood relative(s) with a family history suggestive of a BRCA mutation (those families having a member(s) with primary breast cancer diagnosed at or before the age of 40, primary breast cancer and ovarian cancer within the same family or family member, male relative with primary breast cancer, a relative with bilateral breast cancer, or multiple generations of family members with primary breast and/or ovarian cancer)

A known BRCA mutation

A family member carrying a known BRCA mutation

A personal history of a high risk breast lesion, including lobular carcinoma in situ and atypical hyperplasia

A personal history of primary breast cancer (invasive or in-situ) treated with unilateral mastectomy

Patients must have a mammogram performed within the last 6 months, and the mammography images must be available for review at the time of the MR interpretation.

Age 25-75

Female

Exclusion Criteria:

They are unable to return in one year for follow-up exam

Medical history includes:

Previous breast cancer treated with breast conservation

History of benign excisional biopsy in the previous 24 months

History of a benign core needle biopsy or FNA in the previous 12 months

History of metastatic cancer

45 minute prone scan cannot be tolerated

Pregnant, as a mammogram for correlation with MR is required

History of breast MR in the last 6 months

Contacts and Locations

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study.
To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below.
For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00588614