anti-Transcription Factor 12 (TCF12) Antibodies

The protein encoded by TCF12 is a member of the basic helix-loop-helix (bHLH) E-protein family that recognizes the consensus binding site (E-box) CANNTG. Additionally we are shipping TCF12 Proteins (7) and TCF12 Kits (2) and many more products for this protein.

haploinsufficiency of TCF12 causes coronal synostosis in humans and that severe bilateral coronal synostosis occ (show TWIST1 Antibodies)urs in mice with 50% of the wild-type dosage of both the T (show TWIST1 Antibodies)cf12 and Twist1 genes highlights the key role of TCF12 acting with TWIST1.

As a first exploitation of this unique cohort, we identify three novel candidate dyslexia genes, ZNF280D (show ZNF280D Antibodies) and TCF12 at 15q21, and PDE7B (show PDE7B Antibodies) at 6q23.3, by molecular mapping of the familial translocation with the 15q21 breakpoint.

Mouse (Murine) Transcription Factor 12 (TCF12) interaction partners

HEB (show FREM1 Antibodies) is a fundamental link between Nodal signalling, the derepression of a specific class of poised promoters during differentiation, and lineage specification in mouse embryonic stem cells

severe bilateral coronal synostosis occurs in mice with 50% of the wild-type dosage of both the Tcf12 and Twist1 (show TWIST1 Antibodies) genes highlights the key role of TCF12 acting with TWIST1 (show TWIST1 Antibodies) in the normal development of the coronal sutures

the Tcf12 gene may be involved in the control of proliferating neural stem cells and progenitor cells

TCF12 Antigen Profile

Protein Summary

The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH) E-protein family that recognizes the consensus binding site (E-box) CANNTG. This encoded protein is expressed in many tissues, among them skeletal muscle, thymus, B- and T-cells, and may participate in regulating lineage-specific gene expression through the formation of heterodimers with other bHLH E-proteins. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.