The U.S. government has given Pakistan a Friday deadline to strip its United Nations ambassador’s diplomatic immunity so he can face domestic-violence charges in Manhattan.

The Manhattan’s district attorney’s office said it would seek misdemeanor assault charges against Ambassador Munir Akram if his government waives his diplomatic immunity.

The case stems from a police call at 1:36 a.m. Dec. 10 from a woman who said a man she identified as her husband had smashed her head into a wall, and she asked that officers come to a townhouse on East 92nd Street.

She said he was a diplomat and had hit her before, a police spokeswoman said.

When officers arrived, Marijana Mihic, 35, gave a different version of events, saying she had fallen after the man, now referred to as her “boyfriend,” had grabbed her in an argument, the spokeswoman said.

U.S. and Pakistani officials said the request leaves Pakistan with three options: lifting Akram’s immunity and allowing him to be prosecuted, sending him home and naming a replacement, or refusing the State Department request.

“We have asked them to waive immunity. That’s what we normally do in cases like this,” department spokesman Richard Boucher told a daily briefing.

“We are prepared to prosecute him on a misdemeanor assault charge” should immunity be waived, said Barbara Thompson, spokeswoman for Manhattan District Attorney Robert Morgenthau.

The ambassador could face up to one year in jail if convicted.

Mihic has refused to press charges.

Akram denied any wrongdoing and told CNN, “My government is handling this. I prefer to leave it at that.”

Pakistan has agreed to respond to Washington’s request by tomorrow.

Mansoor Suhail, spokesman for the Pakistan mission to the United Nations, told The Post the charges are “unfounded” and that the woman remains a “friend” of the ambassador.