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I want to give you both an overview of the antiphospholipid antibody syndrome and update the audience on things that happened at the recent meeting in Tours, France, which gave some of the most current and up-to-date information on the syndrome. (hss.edu)

According to Harrogate and District, NHS Foundation Trust, Anti-Phospholipid Syndrome (APS), which is an acquired thrombophilic state, causes three or more unexplained consecutive miscarriages before 12 weeks of gestation. (onlymyhealth.com)

They looked at antibodies to anticardiolipin , antiphosphoserine, and anti-β2-glycoprotein 1 across each of the groups and further whether levels of these APLAs correlated with specific behaviours or impairments in behaviours. (blogspot.com)

There is a good paper by him in the recent Journal of Autoimmunity that describes the differences between the two types of livedo that occur, the one with antiphospholipid antibody and the one with vasculitis. (hss.edu)

A further addition to the area of autoimmunity and autism is that of the paper by Careaga and colleagues * who quite recently reported on the presence of increased anti-phospholipid antibodies ** in a cohort of children diagnosed with an autism spectrum condition as part of the CHARGE study . (blogspot.com)

This study provides the first evidence for elevated production of anti-phospholipid antibodies in young children with ASD and provides a unique avenue for future research into determining possible pathogenic mechanisms that may underlie some cases of ASD. (hindawi.com)

In the current study, we investigated whether there were elevated levels of anti-phospholipid antibodies in a cross-sectional analysis of plasma of young children with ASD compared to age-matched typically developing (TD) controls and children with developmental delays (DD) other than ASD. (hindawi.com)

The yellow bars are women who have had prior losses, and you can see that in this group of patients the history of a prior fetal loss and a high titer antibody gave an over 80% probability of losing the current pregnancy. (hss.edu)

There was stepwise increment from negative titers but it was also true that the history of a prior loss even in women who had negative antibody titers also predicted loss at about a 2:1 ratio, that is, a prior loss plus the high titer antibody. (hss.edu)

Although the underlying mechanisms are still largely unraveled, several pathogenic pathways are identified, such as antibody-mediated neurotoxicity, vasculopathy due to anti-phospholipid antibodies and other mechanisms, and cytokine-induced neurotoxicity. (springer.com)