Abstract

For the whole of the 20th century it was believed that the Black Death and all the plagues of Europe (1347–1670) were epidemics
of bubonic plague. This review presents evidence that this view is incorrect and that the disease was a viral haemorrhagic
fever, characterised by a long incubation period of 32 days, which allowed it to be spread widely even with the limited transport
of the Middle Ages. It is suggested that haemorrhagic plague emerged from its animal host in Ethiopia and struck repeatedly
at European/Asian civilisations, before appearing as the Black Death. The CCR5-Δ32 mutation confers protection against HIV-1 in an average of 10% of the people of European origin today. It is suggested that
all the Δccr5 alleles originated from a single mutation event that occurred before 1000 bc and the subsequent epidemics of haemorrhagic plague gently forced up its frequency to 5×10−5 at the time of the Black Death. Epidemics of haemorrhagic plague over the next three centuries then steadily raised the frequency
in Europe (but not elsewhere) to present day values.