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It comes as a major blow to Chris Coleman who is already without talisman Gareth Bale through suspension and Liverpool youngster Ben Woodburn who pulled out of the squad having suffered a calf injury.

Hal Robson-Kanu in action for Wales in the reverse fixture against Serbia

It means Burnley hitman Sam Vokes is almost certain to lead the line for Coleman's side at the weekend, with the 27-year-old set to make his 50th appearance for the national side.

Robson-Kanu has been replaced in the squad by Swansea City youngster Daniel James who was one of the stars in Wales' recent debut in the Toulon Tournament.

James scored a late winner as Robert Page's side beat Bahrain 1-0 in their second group match of the tournament, with Wales going on to finish second in their group behind the Ivory Coast.

They missed out on a place in the semi-finals as a best runner-up, with Scotland's 2-1 victory over Indonesia ending Wales' fine run in their first ever appearance in the competition in which they went unbeaten.

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James was also one of the stars of Swansea City Under-23's magnificent campaign, with the young Swans winning the Premier League 2 Division 2 title as well as tasting glory in the Premier League Cup.

Wales - who are also without suspended Neil Taylor and injured trio Andy King, James Collins and Jonny Williams for the game in Belgrade - currently trail Serbia and Republic of Ireland by four points in Group D at the midway stage of their qualifying campaign.