More ELISA Kits for APOL1 Interaction Partners

Human Apolipoprotein L, 1 (APOL1) interaction partners

Plasma concentrations of TNFR1, TNFR2, and KIM1 are independently associated with renal outcome and improve discrimination or reclassification of African ancestry individuals with a high-risk APOL1 genotype and preserve renal function.

APOL1 risk variants did not associate with subclinical markers of atherosclerosis or left ventricular hypertrophy in middle-aged black adults with preserved kidney function.

Review of the role of APOL1 in kidney disease in children and young adults of African ancestry. APOL1 explains almost 70% of the excess risk of kidney disease in those of African descent, and is common in children with glomerular disease.

Association of chronic kidney disease with APOL1 risk alleles was not identified in Aboriginal people in remote areas of Australia.

APOL1, alpha-thalassemia, and BCL11A variants as a genetic risk profile for progression of chronic kidney disease in sickle cell anemia.

Among blacks with established moderate CKD, the APOL1 high-risk variants are associated with greater risk of incident proteinuria. After proteinuria onset, kidney function declines more rapidly but does not differ by APOL1 risk status.

In individuals at risk for nondiabetic kidney disease based on African ancestry, the majority of that risk can be explained by two variants in the APOL1 gene.

Considering APOL1 evolution also may help us understand how APOL1 risk variants cause kidney disease in modern humans.

APOL1 variants are associated with HIV-associated nephropathy(HIVAN), a podocyte disease,but not with HIV-immune complex disease, primarily a disease of the mesangium.

the associations of the APOL1 risk variants with microalbuminuria, incident CKD, and subsequent kidney function decline implicate a potential role in both the development and progression of CKD. Unlike the consistent association with CKD, the association of the APOL1 risk variants with cardiovascular disease is less clear.

The presence of two APOL1 renal risk variants in deceased donors shortens survival of their renal allografts. No study has examined the potential interaction of APOL1 genotype of the donors, deceased or living, and recipients.

expression of G1 or G2 APOL1 results in significantly more cell death compared with wild-type APOL1 (G0) in various human cells in culture

Genetic variant in apolipoprotein L1 is not associated with preterm birth in African American population.

This is the first report of a specific association of APOL1 with small vessel disease (SVD) ischemic stroke.

study found strong evidence for no association with Trypanosoma brucei rhodesiense Human African trypanosomiasis and APOL1 G2 in two Ugandan populations

APOL1 variants are not associated with longitudinal blood pressure in blacks.

Novel relationships were identified between higher plasma FGF23 concentrations and absence of APOL1 renal-risk genotypes with higher mortality in African Americans with diabetes.

Letter: no APOL1 risk allele variants in Indian patients with chronic kidney disease.

APOL1 copy number variations may be not associated with susceptibility to focal segmental glomerulosclerosis in Chinese population.

Zebrafish Apolipoprotein L, 1 (APOL1) interaction partners

zApoL1 is essential for proper blood filtration in the zebrafish glomerulus and that zApoL1 affects the expression of nephrin

APOL1 Antigen Profile

Antigen Summary

This gene encodes a secreted high density lipoprotein which binds to apolipoprotein A-I. Apolipoprotein A-I is a relatively abundant plasma protein and is the major apoprotein of HDL. It is involved in the formation of most cholesteryl esters in plasma and also promotes efflux of cholesterol from cells. This apolipoprotein L family member may play a role in lipid exchange and transport throughout the body, as well as in reverse cholesterol transport from peripheral cells to the liver. Several different transcript variants encoding different isoforms have been found for this gene.