Opening in October 2006, a London production at the National Theatre on the Lyttelton stage, also directed by Wolfe, ran in repertory with Marianne Elliot's production of Thérèse Raquin to January 2007. The production did not transfer to the West End but did win the Olivier Award for Best New Musical. The opening night cast in London starred Tonya Pinkins as Caroline. Other cast members included Pippa Bennett-Warner as Emmie Thibodeaux, Anna Francolini as Rose Stopnick Gellman, Hilton McRae as Mr. Stopnick, Perry Millward, Jonny Weldon and Greg Bernstein alternating as Noah and Clive Rowe as the dryer/bus.[4]

Pinkins and Anika Noni Rose (Emmie Thibodeaux) reprised their roles in late 2004 at the Ahmanson Theatre, Los Angeles, California[5] and in early 2005 at the Curran Theatre, San Francisco, California.[6] The Chicago premiere at the Court Theatre in fall 2008 earned four Jeff awards,[7] for director Charles Newell, Musical Director Doug Peck, star E. Faye Butler, and best production of a musical at a large scale theater.

The Greater Hartford Academy of the Arts (GHAA) became the first high school to perform Caroline, Or Change. It ran in December 2011 in Hartford, CT

Caroline Thibodeaux is a black maid for a Jewish family, the Gellmans, spending her days in their dank basement doing the laundry for the pitiful sum of $30 a week. The Gellmans' young son, Noah, has a strong emotional connection to Caroline, a single parent who remains stoic amid the sweep of change she sees around her. Regardless of the circumstances, whether it is the death of a president, her daughter's growing activism and misunderstood dismissal of what she perceives to be Caroline's choice to remain a maid, her son's enlistment in Vietnam, a fight with a newly college-bound friend, or a spin with the dryer, Caroline remains unflappable. She provides stability during Noah's grief at his mother's death from cancer, and her constant anger appeals to his constant sorrow. Noah's new stepmother Rose, unable to give Caroline a raise, enlists Caroline's help in a plan to teach Noah a lesson about leaving change in his pants pocket. Rose tells Noah and Caroline that Caroline should keep the money Noah leaves in his pockets. Caroline loathes the unintended humiliation of taking money from a child—but her own children lack money for toys, sweets, dentistry, and Christmas presents, and she is late with the rent because her salary has gone toward two special meals for her children. As an experiment and while fantasizing to exchange his isolating family for the imagined compassion of hers, Noah deliberately leaves money in his pockets, dreaming that Caroline's family now talk about his generosity over dinner.

The lesson goes awry when the ownership of a $20 bill is contested in the laundry, and Caroline's relationship with eight year-old Noah is irrevocably ruptured. After a week of reflection, with deep regret for harsh words spoken in anger, Caroline decides to return to her dehumanizing work as a maid. In a furious and broken prayer to God, she acknowledges that she'll never escape her circumstances, and she vows to crush her soul so that she can resist the pride that would grant her change but cost her the money that she needs to support her family. Against a background of the death of JFK, the Vietnam war, and the non-violent direct action protests organized by Martin Luther King, the tide of change continues to define Caroline's place in history, a working mother, bearing up under a broken marriage, economic hardship, and racial inequality. Forever a maid, her tragic destiny sears the memories of the two parted principals. The tragedy is ultimately offset by an epilogue, a heroic solo sung by her daughter Emmie, laying claim to the hope and determination for a better life for Caroline's appreciative and proud children.