Abstract: In the centrosymmetric tetranuclear title compound, [Cu4I4(C10H8N2S2)2], there are two different CuI atoms with tetrahedral coordination geometries. One is chelated by a pyridine N atom and an S-donor from one di-2-pyridyl disulfide ligand and coordinated by two I atoms, while the second CuI atom is coordinated by a pyridine-N and three I atoms. Iodine bridges between the CuI atoms form a tetranuclear structure.