WACO, Texas (AP) - Trevone Boykin threw for 261 yards and four touchdowns, all those scores coming on third-down plays, and TCU won 49-21 at Baylor on Saturday night to end the Bears' nine-game home winning streak.

Boykin, the redshirt freshman who completed 22 of 30 passes without a turnover, added 56 yards rushing with a late 3-yard TD for the Horned Frogs (5-1, 2-1 Big 12) in his second start.

The Horned Frogs took advantage of six turnovers by Baylor (3-2, 0-2). That included four interceptions by Nick Florence, who had TD passes of 74 and 77 yards to Terrance Williams.

Baylor's home winning streak had included a wild season-opening 50-48 victory over the Frogs last year, months before TCU joined the Bears in the Big 12. This was the first game between the teams only about 100 miles apart since 1995, the last year of the Southwest Conference.

Boykin had a full week to prepare to start this game. He threw three interceptions in his first start, a loss at Iowa State a week earlier when he had been working at tailback before Casey Pachall's arrest on suspicion of drunken driving only two days before the game.

Pachall, the second-year starting quarterback, has since withdrawn from school and entered an inpatient treatment program.

Florence succeeded Heisman Trophy winner Robert Griffin III and entered the game leading the nation in total offense (435 yards a game). He threw his 74-yard pass to Williams on the second play of the game, but the next two possessions ended with interceptions.

The first a nifty pick by Jason Verrett that set up Boykin's tying 18-yard TD pass to Cam White.

Verrett made a two-handed grab, snagging the ball only inches off the ground - so close that officials looked at replays to confirm the interception. TCU then went 55 yards in eight plays, including Boykin's scrambling 25-yard run on third-and-15, for a 7-7 tie.

Chris Hackett had the other interception, and also recovered a fumble at the TCU 25, setting up a 15-play drive that ended with White's 15-yard touchdown catch for a 14-7 halftime lead.

Florence was 12 of 19 passing for 289 yards. He was sacked three times, and finished with minus-5 yards rushing on eight carries.

Boykin had three interceptions in the 37-23 loss to Iowa State, a game in which freshman running back B.J. Catalon fumbled twice. Catalon ran 17 times for 79 yards against Baylor.

TCU was good on 14 of 19 third-down conversions, and even was good on a fourth-and-4 on the go-ahead drive in the second quarter.

The Horned Frogs had the ball for nearly 42 minutes, and had scoring drives of 15 and 16 plays.

Right after Joyce Boyce's 2-yard touchdown run for TCU late in the third quarter, Baylor got within 28-21 on the next play when Florence hit Williams in stride for a 77-yard score late in the third quarter. The quarterback took a hard hit as he let the ball go, and never saw Williams catch the ball.

But the Horned Frogs scored three touchdowns in the fourth quarter. That included a 15-yard catch by Josh Boyce, who earlier ran 2 yards for a score.