You are here

P&T TV

Eric Van Cutsem, MD, discusses a subgroup analysis involving patients 75 years of age and older in the Consign study of regorafenib for treatment-refractory metastatic colorectal cancer. The analysis found no major differences in safety compared with younger patients as long as the patients were fit enough to be eligible for treatment—so age itself is no reason to withhold regorafenib.

Nicola Gökbuget, MD, of Goethe University in Frankfurt, Germany, discusses “very positive” results from trials of the bispecific T-cell engager blinatumomab in treating acute lymphocytic leukemia. Among 116 patients with high levels of minimal residual disease (MRD), 80% were found to be MRD-negative after just one cycle of treatment. Survival results were best if patients were treated in their first remission.

Robert A. Hromas, MD, Chair of the Department of Internal Medicine at the University of Florida College of Medicine, describes “very exciting” findings about venetoclax in treating chronic lymphocytic leukemia (CLL). The drug was very effective among hard-to-treat patients with the 17p deletion, and he believes it may hold promise for a range of other CLL patients as well.