Antibody Pairing Studies

Characterization SOP Files

Background

NCI Identification Number:

10280

Antigen Name:

Fatty acid-binding protein, epidermal

CPTC Name:

CPTC-FABP5

Keywords:

FABP5; E-FABP; EFABP; PA-FABP; PAFABP

Function:

This gene encodes the fatty acid binding protein found in epidermal cells, and was first identified as being upregulated in psoriasis tissue. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism.

High specificity for fatty acids. Highest affinity for C18 chain length. Decreasing the chain length or introducing double bonds reduces the affinity. May be involved in keratinocyte differentiation.