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Brooklyn federal prosecutors have built an iron-clad case against notorious Mexican drug lord Joaquín “El Chapo” Guzmán — and plan to send him to prison for the rest of his life, according to court documents unsealed Friday.

Prosecutors have arranged for dozens of cooperating witnesses who have dealt face to face with Guzmán for decades to testify about his “power, corruption and violence” within his Sinaloa Cartel — the largest drug-trafficking network in the world, court papers state.

The witnesses will include cartel leaders from Colombia.

“Spanning the entire time period of the charged conduct, these witnesses will testify to every aspect of Guzmán’s organization from its inception in the late 1980s through his building of an international empire, including his expansion into Central and South America and opening of drug distribution centers throughout the United States,” the documents say.

Guzmán will be arraigned Friday afternoon in Brooklyn federal court on a 17-count indictment charging him with money laundering and the manufacture and distribution of cocaine, heroin and other deadly drugs.

If convicted, he faces life in prison.

At the arraignment, prosecutors will argue that, if released, Guzmán poses a danger to society and is a flight risk.

Prosecutors will also make the case that Guzmán is “extremely violent” and “maintains caches of weapons to be used for protection and to punish those who act against Guzmán’s interests,” the court papers state.

“Therefore, witnesses for the government and their families, many of whom still reside in Mexico without protection, would be in grave danger of physical harm or even death as a reprisal for their cooperation with the government should Guzmán be at liberty,” the documents say.

The indictment detailed the inner workings of El Chapo’s insidious Sinaloa Cartel and how the kingpin imported over 500 tons of cocaine into the country during his reign of more than two decades

According to the indictment, Guzmán employed thousands of henchmen — some of whom were senior leaders in charge of drug-trafficking and money-laundering activities, as well as paying off law enforcement types to keep the operation running smoothly.

Other members were lower on the food chain, including security guards to protect the leadership, hit men to rub out anyone who messed with them and narcotics “transporters” who used boats, submarines, trucks and airplanes, the papers say.

The transporters would typically funnel the drugs from Colombia to Mexico and into the United States, “where the drugs were consumed,” according to the documents.

Guzmán allegedly raked in $14 billion with his US drug operation — and laundered every penny of it back to Mexico in vehicles with hidden compartments.

The 5-foot-6 ringleader, also known as “Shorty,” has been indicted in several other jurisdictions — including Miami, California, Texas and Chicago.

Over the past 13 years, he has become infamous for his Houdini escapes from Mexican prisons.

In 2001, he easily slipped out of a Mexican prison and went on the lam for 13 years before he was recaptured.

Then, in 2015, he broke out a second time — using a motorcycle to escape through a mile-long underground tunnel.

After spending six months on the run, he was recaptured in a deadly shootout with Mexican naval special forces.