As a luminescence host material, Zn2SiO4 can produce several colors. In this research, Zn2SiO4 has been synthetized by means of sonochemical method for the first time. Through ultrasonic waves, the reaction produced a nano-sized crystal at room condition (25

oC, 1 atm). Sonication time, base concentration, and aging time are 6 hours, 5,38 M, and 48 hours respectively as the optimal condition for the reaction. After drying at 100 oC, the crystal structure was found to be a willemite structure that shown by peaks of at (003), (401), (521), and (042) of hkl reflecting using X-ray diffraction (XRD). The crystal also has been observed by scanning electrone microscope (SEM). By calculating the Full Width of Half Maximum (FWHM), the size of the crystal was found to be 10,3 nm. Meanwhile, the band gap energy was around 3,27 eV obtained from the UV-Visual reflectance spectrum calculation. The sonochemical synthesized Zn2SiO4 has as similar properties as the other crystal by different methods.