When comparing Paint Shop Pro vs Pixen, the Slant community recommends Paint Shop Pro for most people. In the question“What are the best pixel art / sprite editors?”Paint Shop Pro is ranked 15th while Pixen is ranked 25th. The most important reason people chose Paint Shop Pro is:

You can work with a pre-defined number of color palettes, save and load custom palettes, and access several modes to reduce the number of colors on a picture.