Vilazodone for major depressive disorder: a systematic review of the efficacy and safety profile for this newly approved antidepressant - what is the number needed to treat, number needed to harm and likelihood to be helped or harmed?

..We also discuss the utility of depot antipsychotic formulations for improving the chances of attaining long-term therapeutic results...

Vilazodone for major depressive disorder: a systematic review of the efficacy and safety profile for this newly approved antidepressant - what is the number needed to treat, number needed to harm and likelihood to be helped or harmed?

..The product label is commonly used as an authoritative source for drug information, especially for new medications that have a limited published evidence base. Key elements of the product label are descriptions of safety and tolerability...

A systematic review of meta-analyses of the efficacy of oral atypical antipsychotics for the treatment of adult patients with schizophrenia

..It is also approved for the treatment of adults with schizoaffective disorder, both as a monotherapy and as adjunctive therapy to mood stabilizers and/or antidepressants. Paliperidone is the active metabolite of risperidone...

Long-term safety and tolerability of lurasidone in schizophrenia: a 12-month, double-blind, active-controlled study

..All-cause discontinuation rates were higher for lurasidone versus risperidone. Long-term treatment with lurasidone was generally well tolerated in this study, with minimal effects on weight and metabolic outcomes...

L CitromeDepartment of Psychiatry, New York University School of Medicine, New York, NY, USAInt J Clin Pract 65:330-40. 2011

..To describe the efficacy and safety of inhaled loxapine, a new formulation of an older antipsychotic being developed for the treatment of agitation associated with schizophrenia or bipolar disorder...

Lurasidone for schizophrenia: a brief review of a new second-generation antipsychotic

Leslie CitromeDepartment of Psychiatry, New York University School of Medicine, New York, NY, USAClin Schizophr Relat Psychoses 4:251-7. 2011

..Lurasidone is associated with minimal weight gain and no clinically meaningful alterations in glucose, lipids, or the ECG QT interval...

Olanzapine-fluoxetine combination for the treatment of bipolar depression

..Mood stabilizers such as valproate may be helpful in instances of poor impulsivity and personality disorders. Other agents that have been successfully used include β-adrenoceptor antagonists (β-blockers) and antidepressants...

Atypical antipsychotics in the treatment of the persistently aggressive psychotic patient: methodological concerns

..g. randomization) used in typical designs of psychopharmacological clinical trials. Current research methods should be modified and new ones developed in order to progress in assessing the antiaggressive effects of treatments...

Iloperidone redux: a dissection of the Drug Approval Package for this newly commercialised second-generation antipsychotic

L CitromeDepartment of Psychiatry, New York University School of Medicine and the Nathan S Kline Institute for Psychiatric Research, Orangeburg, NY, USAInt J Clin Pract 64:707-18. 2010

..To describe the contents of a Drug Approval Package and to describe the efficacy and safety of iloperidone for the treatment of schizophrenia...

Compelling or irrelevant? Using number needed to treat can help decide

L CitromeDepartment of Psychiatry, New York University School of Medicine, The Nathan S Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USAActa Psychiatr Scand 117:412-9. 2008

....

Iloperidone for schizophrenia: a review of the efficacy and safety profile for this newly commercialised second-generation antipsychotic

..The aim of the study was to describe the efficacy and safety of iloperidone for the treatment of schizophrenia...

Heterogeneity of violence in schizophrenia and implications for long-term treatment

J VolavkaDepartment of Psychiatry, New York University School of Medicine, New York, NY, USAInt J Clin Pract 62:1237-45. 2008

..The aim of this review is to address the subtyping of violent behaviour in schizophrenia, and to relate the subtypes to treatment...

Treatments for bipolar disorder: can number needed to treat/harm help inform clinical decisions?

T A KetterDepartment of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, USAActa Psychiatr Scand 123:175-89. 2011

..To compare bipolar treatment interventions, using number needed to treat (NNT) and number needed to harm (NNH)...

Paliperidone: quo vadis?

L CitromeDepartment of Psychiatry, New York University School of Medicine, and the Nathan S Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USAInt J Clin Pract 61:653-62. 2007

..With the impending availability of oral risperidone as a generic medication, cost of oral paliperidone will likely become a significant obstacle to its use...

Asenapine for schizophrenia and bipolar disorder: a review of the efficacy and safety profile for this newly approved sublingually absorbed second-generation antipsychotic

L CitromeDepartment of Psychiatry, New York University School of Medicine, New York, NY, USAInt J Clin Pract 63:1762-84. 2009

..To describe the efficacy and safety of asenapine for the treatment of schizophrenia and bipolar disorder...

Violent patients in the emergency setting

L CitromeDepartment of Psychiatry, New York University, New York, USAPsychiatr Clin North Am 22:789-801. 1999

..The use of typical neuroleptics may lead to side effects, such as akathisia, which may in turn precipitate additional agitation. This may be obviated with the introduction of IM preparations of atypical antipsychotics...

Interpreting and applying the EUFEST results using number needed to treat: antipsychotic effectiveness in first-episode schizophrenia

..07% of injections, requiring patients to be observed for 3 h after injection. At present, there are no studies available that directly compare olanzapine pamoate with other antipsychotics other than oral olanzapine...

Paliperidone palmitate - review of the efficacy, safety and cost of a new second-generation depot antipsychotic medication

L CitromeDepartment of Psychiatry, New York University School of Medicine, New York, NY, USAInt J Clin Pract 64:216-39. 2010

..To describe the efficacy, safety and cost of paliperidone palmitate, a depot antipsychotic medication recently approved for the treatment of schizophrenia...

Levomilnacipran for major depressive disorder: a systematic review of the efficacy and safety profile for this newly approved antidepressant--what is the number needed to treat, number needed to harm and likelihood to be helped or harmed?

..Additional considerations in interpreting NNT are discussed, including the importance of defining acceptable response, adverse outcomes of interest, the effect of time, and the importance of individual baseline characteristics...

Schizophrenia, Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) and number needed to treat: how can CATIE inform clinicians?

L CitromeDepartment of Psychiatry, New York University School of Medicine, New York, NY, USAInt J Clin Pract 60:933-40. 2006

..NNT and NNH can help place the wide array of CATIE results into clinical context, and permits quantification of the differences observed between the antipsychotics that were tested...

L CitromeDepartment of Psychiatry, New York University School of Medicine, New York and Nathan S Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USAActa Psychiatr Scand 121:94-102. 2010

..When appraising evidence clinicians are confronted with two types of comparisons: ratios, such as relative risk, and absolute differences, such as number needed to treat (NNT) or number needed to harm (NNH)...