Method and Apparatus of Automatically Isolating and Purifying Nucleic Acid - A method of automatically isolating and purifying nucleic acid from a nucleic acid-containing specimen is provided, the method comprising: injecting a liquid into a cartridge for isolation and purification of a nucleic acid including at least two openings from one opening of the at least two openings, in which the cartridge includes a container having the at least two openings and containing a nucleic acid-adsorbent solid phase; passing the liquid through the nucleic acid-adsorbent solid phase by a pressure difference generated by a pressure generation means for generating a pressure difference between the inside and outside of the container; and discharging the liquid from the other opening of the container to the outside of the container by a pressure difference generated by the pressure generation means, wherein a pressure generated in the inside of the container by the pressure generation means is measured, a pressure change velocity and a pressure change acceleration are calculated on the basis of the value of the measured pressure, and the timing of completion of discharge of the liquid from the container is determined by use of a temporal change pattern of at least one of the measured pressure, the pressure change velocity and the pressure change acceleration.

2008-11-06

20080275229

Method for increasing the speed of nucleic acid amplification reactions - The speed of a nucleic acid amplification reaction, such as the Polymerase Chain Reaction (PCR), can be increased by setting the temperature of heat sources above and below the desired denaturation, annealing, and extension temperatures. The reaction mixture is only contacted with the heat sources long enough for the desired temperatures to be reached.

2008-11-06

20080275230

POLYMERS HAVING COVALENTLY BOUND ANTIBIOTIC AGENTS - An antimicrobial composition comprising: a complex of a polysaccharide covalently bonded with an antibiotic. A medical device having an antimicrobial composition comprising: a complex of an oxidized regenerated cellulose covalently bonded with gentamicin.

2008-11-06

20080275231

Method for Preparing Regenerated Cellulose Fiber by Two-Step Coagulating Bath Process - The present invention relates to a non-toxic process and system for pilot-scale production of cellulose products, and particularly to a process and system for pilot-scale production of cellulose products by using aqueous sodium hydroxide/urea solution pre-colled to lower than −8° C., in which cellulose could dissolved rapidly. The said process and system can be used to produce fibers, films, chromatographic packings, or nonwovens of regenerated cellulose, as well as to produce a variety of high added-value products by adding other materials such as functional materials, nano-materials, etc.

2008-11-06

20080275232

CHLORINS POSSESSING FUSED RING SYSTEMS USEFUL AS PHOTOSELECTIVE COMPOUNDS FOR PHOTODYNAMIC THERAPY - The present invention provides a process of preparation of naphthochlorins and other chlorins with annelated ring systems useful for photodynamic therapy and the compounds themselves. The method for producing naphthochlorin compounds include contacting compounds such as meso-(2′-hydroxymethyl)phenyl porphyrin or meso-(2′-N,N,N-trialkylaminomethyl)phenyl porphyrin precursors with at least one acid catalyst at sufficient temperature for a sufficient time to yield the desired conversion. In a similar manner chlorins possessing annelated ring systems may be made from compounds such as meso-(2′-hydroxymethyl)aryl porphyrins or meso-(2′-N,N,N-trialkylaminomethyl)phenyl porphyrin. The procedures described herein provide new routes for synthesizing naphthochlorins and chlorins with annelated ring systems.

Method for Producing Pure Melamin - The invention relates to a method for producing pure melamine by preparing a melamine melt, which is obtained in a high pressure process and from which the reaction gases are removed. Said method is characterized in that the melamine melt is quenched by water with a purity in excess of 95 wt. %, that NH

Method for Obtaining Pure Tetrahydrocannabinol - The invention relates to a method for obtaining pure tetrahydrocannabinol from reaction mixtures containing tetrahydrocannabinol compounds or from raw products containing tetrahydrocannabinol compounds. According to said method, the tetrahydrocannabinol compounds in the reaction mixture or in the raw product are converted into crystallisable derivatives, preferably using a suitable solvent, said derivatives are then crystallised and isolated, and the pure tetrahydrocannabinol compounds are then obtained from the crystallised derivatives. The invention also related to the use of compounds produced in this way for the production of a medicament for human therapy, and to the medicaments thus produced.

Metallic Compound and Organic Electroluminescence Device Comprising the Same - The present invention relates to a light emitting transition metal compound represented by the Chemical Formula 1 and Chemical Formula 2 and an organic electroluminescence device including the same. In the above Chemical Formulae 1 and 2, M is Ir, Pt, Rh, Re, Os, or the like, m is 2 or 3 and n is 0 or 1, where the sum of m and n is 3, provided that the sum of m and n is 2 when M is Pt, X and Z are the same or different and may be N or P, and Y is O, S, or Se.

Polymorphic Forms of Dolasetron Base and Processes of Preparing Dolasetron Base, Its Polymorphic Forms and Salt Thereof - The present disclosure relates to a process for the preparation of endo-hexahydro-8-(3-indolylcarbonyloxy)-2,6-methano-2H-quinolizin-3(4H)-one or Dolasetron base. It also discloses a process for the preparation of endo-hexahydro-8-(3-indolylcarbonyloxy)-2,6-methano-2H-quinolizin-3(4H)-one mesylate or Dolasetron mesylate. Further, the present disclosure relates to a process for producing Form I of Dolasetron base, and to the novel crystalline polymorphs, Form II, III, IV and V of Dolasetron base and industrial processes for producing them.

2008-11-06

20080275242

3-(Dihydro(Tetrahydro)Isoquinolin-1-Yl)Quinoline Compound - The invention provides compounds which exert excellent fungicidal activities against various plant diseases and are useful as active ingredients of pesticides permitting the control of rice blast and so on even in low dosages. Compounds represented by the general formulae (1a) to (1d) or salts thereof: (1a) (1b) (1c) (or) (1d) wherein R

2008-11-06

20080275243

Process for the Preparation of Polymorphs, Solvates of Aripiprazole Using Aripiprazole Acid Salts - The present invention relates to the novel compounds Methyl 2-[(3S)-[3-[(2E)(7-chloro quinolin-2-yl)ethenyl]phenyl]-3-halopropyl]benzoates (IV) wherein the halo is chloro, bromo, iodo, starting from the known compound Methyl 2-[(3S)-[3-[(2E)-(7-chloroquinolin-2-yl)ethenyl]phenyl]-3-hydroxypropyl]benzoate (1). Reaction of Methyl 2-[(3S)-[3-[(2E)-(7-chloroquinolin-2-yl)ethenyl]phenyl]-3-hydroxypropyl]benzoate (1) with thionyl chloride or with methane sulfonyl chloride—lithium bromide or with trimethyl chlorosilane—sodium iodide in presence or absence of base gives Methyl 2-[(3S)-[3-[(2E)-(7-chloro quinolin-2-yl)ethenyl]phenyl]-3-halopropyl]benzoates.

Processes for the Preparation of Substituted Sulfoxides - The present invention relates to a process for enantioselective synthesis of substituted pyridinylmethyl sulfinyl-benzimidazole of compound of Formula (I). The process includes enantioselective catalytic oxidation of a substituted pyridinylmethyl prochiral sulfide derivative of compound of Formula (II) with an oxidizing agent in the presence of a chiral transition metal complex and a base in the absence of an organic solvent.

2008-11-06

20080275246

PROCESS FOR HALOMETHYL ETHERS OF HYDROXYIMINOMETHYL QUATERNARY PYRIDINIUM SALTS - A halide salt of a 1-(hydroxyiminomethyl-1-pyridino)-3-(halomethyl)-2-oxapropane is prepared by adding a pyridinealdoxime to a bis-halomethylether in such a manner that the bis-halomethylether is maintained in excess throughout the addition. This procedure produces the halide salt of a 1-(hydroxyiminomethyl-1-pyridino)-3-(halomethyl)-2-oxapropane in high yield and purity, which facilitates its use as an intermediate in the manufacture of an asymmetrically substituted 1,3-di(1-pyridino)-2-oxapropane, a class of compounds that are generally useful antidotes to various toxic agents. A prominent member of the class is the dimethylsulfonate salt of 1-(2-hydroxyiminomethyl-1-pyridino)-3-(4-carbamoyl-1-pyridino)-2-oxapropane. The use of mercaptoalkyl-functionalized polymers is disclosed as a preferred metal ion scavenger for a final purification step in the manufacture of these compounds.

Factor Viia Inhibitor - The present invention relates to novel inhibitors or Factors VIIa, IXa, Xa, XIa, in particular Factor VIIa, pharmaceutical compositions comprising these inhibitors, and methods for using these inhibitors for treating or preventing thromboembolic disorders, cancer or rheumatoid arthritis. Processes for preparing these inhibitors are also disclosed.

2008-11-06

20080275251

Novel Intermediates and Their Use - The invention is directed to novel acyloxy imidazole intermediates useful for making certain C-14 oxycarbonyl carbamate pleuromutilin derivatives. The invention is further directed to a process for making such acyloxy imidazole intermediates and to a process for making C-14 oxycarbonyl carbamate pleuromutilin derivatives using such acyloxy imidazole intermediates.

LEWIS ACID CATALYZED HALOGENATION OF ACTIVATED CARBON ATOMS - A practical and efficient method for halogenation of activated carbon atoms using readily available N-haloimides and a Lewis acid catalyst has been disclosed. This methodology is applicable to a range of compounds and any halogen atom can be directly introduced to the substrate. The mild reaction conditions, easy workup procedure and simple operation make this method valuable from both an environmental and preparative point of view.

Stabilized Borane-Tetrahydrofuran Complex - A stabilized borane-tetrahydrofuran complex is disclosed. Also disclosed are processes for the preparation of the borane-tetrahydrofuran complex and methods of storing and transporting the prepared complex. The borane-tetrahydrofuran complexes exhibit enhanced shelf life and increased self-accelerated decomposition temperatures.

2008-11-06

20080275256

Cyclopropanation Process - A process for the cyclopropanation of a substituted alkene, comprising the reaction of the alkene with a carbenoide, generated from dibromomethane and a tri-(C

Epigallocatechin Dimers or Trimers Having Lipase Inhibitory Activity and/or Antioxidant Activity - It is intended to provide a lipase activity inhibitor which shows a high inhibitory activity on pancreatic lipase, regulates the absorption of fat from meals and/or contributes to the regulation or prevention of obesity, a food and a drink containing the same, and a tea-origin lipase inhibitor being highly preferable and not worsening taste. It is also intended to provide a method of producing the lipase inhibitor. It is further intended to provide antioxidative agent. To overcome these problems, an epigallocatechin dimer (oolong homo bis flavans) or trimer is added to foods or drinks. Thus, the absorption of fat from meals can be regulated and an antioxidative effect can be obtained. The above compounds can be produced by reacting epigallocatechin gallate with formaldehyde in the presence of an acid.

METHODS OF MAKING ALKYL ESTERS - A method comprising contacting an alcohol, a feed comprising one or more glycerides and equal to or greater than 2 wt % of one or more free fatty acids, and a solid acid catalyst, a nanostructured polymer catalyst, or a sulfated zirconia catalyst in one or more reactors, and recovering from the one or more reactors an effluent comprising equal to or greater than about 75 wt % alkyl ester and equal to or less than about 5 wt % glyceride.

Process for Production of Alkyltin Alkoxides - A process for the production of alkyltin alkoxides which comprises subjecting at least one alkyltin compound selected from among organotin compounds having tin-oxygen-tin linkages as the starting compound and a hydroxyl compound as the reactant to dehydration to obtain an alkyltin alkoxide corresponding to the starting compound and the reactant, characterized by continuously feeding the starting compound and the reactant into a reactor, discharging a water-containing low boiling point component from the reactor, and continuously withdrawing a reaction fluid containing an alkyltin alkoxide as the bottom from the reactor.

2008-11-06

20080275263

METHOD OF PREPARING ORGANO DIALKYLALKOXYSILANE - The invention relates to the preparation of organodialkylalkoxysilane using a continuous method consisting in bringing an alkanol into continuous contact with an omega-haloalkyl dialkylhalosilane in a countercurrent reactor, such as a plate column or a packed column. The reaction is performed in the aforementioned countercurrent reactor in the presence or absence of a non-reactive solvent with scavenging of the hydrochloric acid formed. The omega-haloalkyl dialkylalkoxysilane thus formed is particularly suitable for use as a starting material for the preparation of organosilicon compounds containing sulphur having general formula (I) by means of sulphidisation reaction on an alkaline metal polysulphide.

2008-11-06

20080275264

PROCESS FOR THE PREPARATION OF HALOGENOALKYLDIALKYL CHLOROSILANE - The present invention relates to a process for the preparation of 3-chloropropyldimethylchlorosilane by hydrosilylation reaction in a reaction medium comprising dimethylhydrochlorosilane and allyl chloride, in the presence of a catalytically effective amount of di-μ-chlorobis(η-1,5-cyclooctadiene)diiridium, the said process being characterized in that at least one auxiliary in the free or supported state selected from the group of compounds consisting of:

2008-11-06

20080275265

Process for the Preparation of (Aminoalkylamino)Alkyl Halides and Conversion to Amifostine - The present invention relates to processes for the preparation of (ω-aminoalkylamino)alkyl halides, their conversion to S-ω-(ω-aminoalkylamino)alkyl phosphothioates, and purification of the crystalline products of the reaction. The preparation process for the (ω-aminoalkylamino)alkyl halides comprises contacting an appropriate alcohol with a brominating agent in the presence of a sulfone solvent under temperature and pressure conditions suitable to effect salt formation without subsequent premature precipitation. The process is especially useful for converting (ω-aminoalkylamino)ethyl alcohol to amifostine.

2008-11-06

20080275266

Method for the Production of Pentene Nitriles From N-Butane - A process is described for hydrocyanating 1,3-butadiene over at least one nickel(0) complex having phosphorus ligands as a catalyst, wherein the 1,3-butadiene is used in a mixture with n-butane and the mixture contains from 60 to 90% by volume of 1,3-butadiene and from 40 to 10% by volume of n-butane.

2008-11-06

20080275267

Plasticiser Esters - Esters produced by the catalyzed reaction of alcohols and acids or anhydrides are neutralized by treatment with an aqueous alkaline alkali metal salt solution in an amount that provides less than a stoichiometric amount of alkali metal salt in relation to the acidity of the crude ester and the amount of water present during the treatment is from 0.8 to 1.4 wt % of water based on the weight of crude ester. When using titanium as the esterification catalyst, the ester resulting from this process contains less than 0.01 ppm by weight of titanium residue, so that it is storage stable when stored in the presence of an antioxidant.

2008-11-06

20080275268

Processes for Producing 3-Methyl-2-Butenyl Acetate - The present invention relates to a method for producing 3-methyl-2-butenyl acetate which comprises reacting 3-methyl-2-buten-1-ol with acetic anhydride in the presence of an inorganic base catalyst and a method for producing purified 3-methyl-2-butenyl acetate which comprises subjecting crude 3-methyl-2-butenyl acetate to a step (A) of contacting it with an aqueous solution of an alkali metal hydrogen sulfite, or a step (B) of contacting it with an aqueous solution of a base, or both steps (A) and (B).

Process for Preparing Purified Terephthalic Acid - The present invention relates to a process for preparing purified terephthalic acid [PTA,], comprising the steps: dissolving crude terephthalic acid [CTA] in an aqueous medium in a reactor; hydrogenating CTA at a temperature of about 260-320° C. and a pressure of about 1100-1300 psig using a hydrogenation catalyst; crystallizing terephthalic acid in the reactor by lowering the temperature of the solution to about 160° C. without evaporation cooling; transferring the content of the reactor to a filtration unit; filtrating the content at a temperature of about 140-160° C. and a pressure of about 40-100 psig, preferably 80-100 psig to obtain a filter cake, washing the filter cake obtained with water having a temperature of about 140-160° C. in the filtration unit; and drying the filter cake.

Method for Synthesizing Long-Chain Phosphonic Acid Derivatives and Thiol Derivatives - A process for synthesizing long-chain phosphonic acid derivatives and thiol derivative is disclosed. One embodiment provides organic compounds which can form a self-assembled monolayer and are obtained by reaction of an olefin with a thiocarboxylic acid and subsequent hydrogenation to give the thiol, or with a phosphite and subsequent hydrolysis to give the phosphonic acid.

Process for the Preparation of Ubihydroquinones and Ubiquinones - A process for the preparation of ubihydroquinones and ubiquinones by condensation of a prenol or isoprenol with a hydroquinone or derivative thereof in the presence of 0.005-1.0 mol % of a catalyst which is a Broensted-acid, a Lewis-acid from the group consisting of a derivative of Bi or In or an element of group 3 of the periodic table of the elements, a heteropolyacid, an NH- or a CH-acidic compound, and optionally oxidizing the ubihydroquinone obtained.

Reduced-Emission Gasification and Oxidation of Hydrocarbon Materials for Liquid Fuel Production - A system and process are disclosed for the controlled combustion of a wide variety of hydrocarbon feedstocks to produce thermal energy, liquid fuels, and other valuable products with little or no emissions. The hydrocarbon feeds, such as coal and biomass, are first gasified and then oxidized in a two-chamber system/process using pure oxygen rather than ambient air. A portion of the intermediate gases generated in the system/process are sent to a Fischer-Tropsch synthesis process for conversion into diesel fuel and other desired liquid hydrocarbons. The remaining intermediate gases are circulated and recycled through each of the gasification/oxidation chambers in order to maximize energy production. The energy produced through the system/process is used to generate steam and produce power through conventional steam turbine technology. In addition to the release of heat energy, the hydrocarbon fuels are oxidized to the pure product compounds of water and carbon dioxide, which are subsequently purified and marketed. The system/process minimizes environmental emissions.

Method of Preparing an Alkyl Aromatic Product with Phosphorus-Treated Zeolite Catalyst - A zeolite catalyst is prepared by treating a zeolite with a phosphorus compound to form a phosphorus-treated zeolite. The phosphorus-treated zeolite is heated to a temperature of about 300° C. or higher and combined with an inorganic oxide binder material to form a zeolite-binder mixture. The zeolite-binder mixture is heated to a temperature of about 400° C. or higher to form a bound zeolite catalyst. The bound zeolite may exhibit at least two

Monitoring and control of processes for making 1-hexene - Processes, methods and apparatus relating to olefin oligomerization include the use of Raman spectrometry to monitor the concentration of reactants, products or other chemical components. One or more oligomerization conditions are adjusted in response to those monitored concentrations. The present processes, methods and apparatus are capable of monitoring olefin oligomerization with the use of low resolution Raman spectrometry equipment, even where there is some degree of overlap between Raman spectral peaks. Apparatus for olefin oligomerization reactions have at least one Raman probe located in the oligomerization equipment, the Raman probe providing an output signal, and Raman spectrometry equipment located outside the oligomerization equipment and operatively connected to at least one Raman probe.

2008-11-06

20080275283

Reactive Distillation for the Dehydration of Mixed Alcohols - The present invention relates to a process for the production of alkene(s) from a feedstock comprising of at least one monohydric aliphatic paraffinic alcohol by using a reactive distillation reactor for the dehydration of mixed alcohols.

2008-11-06

20080275284

PROCESS FOR CONVERTING GASEOUS ALKANES TO LIQUID HYDROCARBONS - Embodiments disclose a process for converting gaseous alkanes to higher molecular weight hydrocarbons, olefins or mixtures thereofs wherein a gaseous feed containing alkanes may be reacted with a dry bromine vapor to form alkyl bromides and hydrobromic acid vapor. The mixture of alkyl bromides and hydrobromic acid then may be reacted over a synthetic crystalline alumino-silicate catalyst, such as a ZSM-5 or an X or Y type zeolite, at a temperature of from about 250° C. to about 500° C. so as to form hydrobromic acid vapor and higher molecular weight hydrocarbons, olefins or mixtures thereof. Various methods are disclosed to remove the hydrobromic acid vapor from the higher molecular weight hydrocarbons, olefins or mixtures thereof and to generate bromine from the hydrobromic acid for use in the process.

Freeze Dry Process for the Preparation of a High Surface Area and High Pore Volume Catalyst - The present invention provides a process for the preparation of a catalyst having a high surface area and pore volume. The process includes freeze drying an intermediary of the catalyst. The present invention further includes a catalyst prepared by a process that includes the freeze drying step. The present invention also includes a catalyst having a high acidity, as indicated by having an ammonium desorption peak at greater than about 500° C. The prevent invention further includes a method of manufacturing isomerized organic compounds using the catalyst.

2008-11-06

20080275287

RF-ENABLEMENT OF AUDITABLE STORAGE FOR HAZARDOUS MATERIALS - A cementitious container that has a low-frequency radio tag containing the container's pedigree and history. The container is used for storage of hazardous waste are disclosed having an inner layer of substantially unhydrated cement in contact with the hazardous waste and an outer layer of hydrated cement. Cementitious hazardous waste containers may be prepared by compressing powdered hydraulic cement around solid hazardous waste materials as well as the encapsulated radio tag that uses low frequency communication. This makes it possible to read and write information though the wall of the container as during transportation to a storage site. Once placed at the storage site, the pedigree, (history contents, Chain of Possession, Proof of delivery, weight), may be checked and verified by reading the tag on a regular basis, (once an hour), to confirm the vessel is intact and has not been moved. Sensors may also be placed on the radio tag to monitor critical parameters like temperature, light levels, movement detectors, and radioactive levels. These may be reported back via the data-link on a regular basis and may also be used as alarms if one moves outside of a specified range.

2008-11-06

20080275288

Encapsulated Reactant and Process - An encapsulated reactant(s) having at least one encapsulant and at least one reactant. An outermost encapsulant is substantially nonreacting, impermeable and nondissolving with water. The reactant(s) contribute to at least one reaction with contaminants in environmental media rendering the environmental media less harmless. Processes for using the encapsulated reactant in environmental media is also hereby claimed.

2008-11-06

20080275289

COIL OPTIMIZATION FOR MAGNETIC STIMULATION - A method of determining an optimal coil shape for use in magnetic stimulation includes identifying a stimulation location and a constraint at the stimulation location. A first electromagnetic effect at the stimulation location is determined. The first electromagnetic effect is induced by a first electrical quantity assigned to a first current element at a first current element location with a first orientation. A second electromagnetic effect at the stimulation location is also determined. The second electromagnetic effect is induced by a second electrical quantity assigned to a second current element at the first current element location with a second orientation. Based on the first electromagnetic effect and the second electromagnetic effect, an optimal orientation of a current element at the first current element location is determined. The optimal orientation is such that the constraint is satisfied. Repeating the process at a plurality of locations yields the optimal coil shape.

2008-11-06

20080275290

Implantable heart assist system and method of applying same - An extracardiac pumping for supplementing the circulation of blood, including the cardiac output, in a patient without any component thereof being connected to the patient's heart, and methods of using same. One embodiment of the intravascular extracardiac system comprises a pump with inflow and outflow conduits that are sized and configured to be implantable intravascularly through a non-primary vessel, whereby it may positioned where desired within the patient's vasculature. The system comprises a subcardiac pump that may be driven directly or electromagnetically from within or without the patient. The pump is configured to be operated continuously or in a pulsatile fashion, synchronous with the patient's heart, thereby potentially reducing the afterload of the heart. In another embodiment, the system is positioned extracorporeally, with the inflow conduit and outflow conduit applied percutaneously to a non-primary vessel for circulating blood to and from the non-primary vessel or between the non-primary vessel and another blood vessel within the patient's vasculature.

2008-11-06

20080275291

Acceleration Protection Suit - An acceleration protection suit having a sparingly extensible outer layer with veins running essentially along a bodily axis of a wearer which deforms when pressurized in such a way as to generate a tension in the sparingly extensible outer layer, with which pressure can be exerted on the wearer to offset G-forces. Means are provided for tightening and adjusting the protective suit to the wearer. At least part of the veins are permeable to gas at least in spots on a side facing the wearer so that the wearer can be air-conditioned by exiting gas when the veins are pressurized.

2008-11-06

20080275292

Vestibular Stimulation System and Method - An apparatus and method in which the portions of the labyrinth associated with the labyrinthine sense and/or the nerves associated therewith are stimulated to perform at least one of the following functions: augment or control a patient's respiratory function, open the patient's airway, induce sleep, and/or counteract vertigo. In one embodiment, the vestibular stimulating system of the present invention includes 1) a stimulation element that performs the actual stimulation of the tissue, 2) a sensor to detect a physiological condition of the patient, and 3) a power/control unit that receives the signals provided by the sensor and causes stimulation energy to be provided to the stimulation element at an appropriate timing, level, pattern, and/or frequency to achieve the desired function. However, the present invention also contemplates eliminating the sensor in favor of applying a predetermined pattern of stimulation to the patient.

2008-11-06

20080275293

Vestibular Stimulation System and Method - An apparatus and method in which the portions of the labyrinth associated with the labyrinthine sense and/or the nerves associated therewith are stimulated to perform at least one of the following functions: augment or control a patient's respiratory function, open the patient's airway, induce sleep, and/or counteract vertigo. In one embodiment, the vestibular stimulating system of the present invention includes 1) a stimulation element that performs the actual stimulation of the tissue, 2) a sensor to detect a physiological condition of the patient, and 3) a power/control unit that receives the signals provided by the sensor and causes stimulation energy to be provided to the stimulation element at an appropriate timing, level, pattern, and/or frequency to achieve the desired function. However, the present invention also contemplates eliminating the sensor in favor of applying a predetermined pattern of stimulation to the patient.

2008-11-06

20080275294

PERICARDIAL INSERTS - Devices, systems and methods are provided which are capable of applying pressure and constraint to the heart and use the pericardium to assist in the application of the pressure and force to the heart.

2008-11-06

20080275295

METHODS OF USING PERICARDIAL INSERTS - Devices, systems and methods are provided which are capable of applying pressure and constraint to the heart and use the pericardium to assist in the application of the pressure and force to the heart.

2008-11-06

20080275297

ENDOSCOPIC GUIDE DEVICE - Various exemplary methods and devices are provided for manipulating and/or anchoring devices and body parts during surgical procedures. In one embodiment, an anchor member is provided for anchoring a device or body part to tissue, such as an internal wall of a body cavity. The device can be, for example, an endoscopic device, an accessory channel coupled to an endoscopic device, or a support member adapted to support or manipulate an organ. The anchor member can include or form an opening through which the device can be inserted. The anchor member or device can thus be manipulated relative to the tissue to control movement of and/or provide support to the device, tools inserted through the device, and/or organs grasped by the device or tools.

2008-11-06

20080275298

Dual View Endoscope - The present invention relates to endoscope system having means to provide simultaneous forward and rear views of a hollow organ. It comprises of first image assembly comprising of forward image lens and forward illumination source disposed at distal end of the endoscope and; second image assembly comprising of rear image lens and rear illumination source disposed on rear view module operatively engaged with the endoscope. Upon deployment of rear view module, rear image lens and rear illumination source face backwards with respect to the endoscope; and in some embodiments of the invention; face towards forward image lens and illumination source disposed at the distal end of the endoscope. According one aspect of the invention, means is provided to prevent interference between the forward image lens of the endoscope and rear illumination source of the rear view module; and between rear image lens of the rear view module and forward illumination source of the endoscope.

2008-11-06

20080275299

ACTUATION DEVICE - An inflatable actuation device that advantageously utilizes fluid pressure to actuate a portion of the shaft of a flexible elongated instrument for performing medical and industrial procedure in a tortuous passage and method of use are described herein. The inflatable actuation device allows an operator to actively manipulate a portion of the elongated instrument shaft within the passage, which facilitate the insertion of the instrument, for example, a medical endoscope into the passage. The present inflatable actuation device comprises an annular bladder, which can be expanded and collapsed, with a lumen to receive the elongated instrument. The inflatable actuation device is activated by inflating the annular bladder with pressurizing fluid supplied from a pressurizing fluid supply controller outside the passage.

2008-11-06

20080275300

COMPLEX SHAPE STEERABLE TISSUE VISUALIZATION AND MANIPULATION CATHETER - Complex shape steerable tissue visualization and manipulation catheters and their methods of use of disclosed herein. The deployment catheter may be articulated utilizing various steering mechanisms to adjust a position of a visualization hood or membrane through which underlying tissue may be visualized.

ENDOSCOPE - An endoscope includes an endoscope insertion portion having a bendable bending portion and a bending mechanism configured to bend the bending portion. The bending mechanism includes a pulley, at least one annular member, a pulling member, and a pulling operation member. The pulley is rotatably driven. The annular member is formed into a C-shape with a cut-out, and can be elastically deformed. The annular member is externally fitted to the pulley with a gap. The pulling member has an intermediate portion wound around the annular member. The distal end portion of the pulling member is connected to the bending portion, and the proximal end portion of the pulling member is connected to the pulling operation member which pulls the pulling member. The width direction position at the winding start position of the pulling member wound around the annular member is made different from the width direction position at the winding end position of the pulling member.

2008-11-06

20080275303

OPERATION DEVICE AND BENDING OPERATION DEVICE OF ENDOSCOPE - In the present invention, there are provided a movement member which includes an engaging section, which is engaged with an intermediate part of an operation shaft of a joystick device, and operates as one body with the operation shaft at a time of performing an inclining operation of the operation shaft, and a damper case in which the movement member is movably inserted, and which holds a viscous fluid which increases a sliding resistance of the movement member when the movement member is moved. Thereby, a desired operational sensation can be always obtained, and a stable bending operation can be performed.

2008-11-06

20080275304

Systems And Methods For Dynamic Optical Imaging - A medical system includes a catheter having an elongated tubular member and an inner core slideably received within the elongated member. The inner core includes an imager on a distal end and is coupled with a control system and an imaging system. The inner core is configured to scan the interior of a lumen by radially rotating around a center axis and axially translating along the center axis while within the elongated member. The medical system is configured to dynamically image a body lumen at a high speed in order to allow for optical imaging in a safe manner without long durations of blood sequestration and displacement. The medical system is configured to obtain three dimensional images of the body lumen with as little as one dimensional scanning of the lumen. Images of the lumen can be stored and viewed at a desired rate after scanning.

2008-11-06

20080275305

Medical scanned beam imager and components associated therewith - A first expression of a first apparatus includes a medical scanned beam imager including an optical dome and a scanner, wherein the optical dome has a variable optical power distribution. A first expression of a second apparatus includes a sleeve assembly which is attachable to a medical scanned beam imager and which includes an objective element which covers an optical dome of the imager when the sleeve assembly is attached to the imager. A second expression of a second apparatus includes a sleeve assembly and a medical scanned beam imager wherein the sleeve assembly is attached to the imager and an objective element of the sleeve assembly covers an optical dome of the imager. A first expression of a third apparatus includes an objective element and a medical scanned beam imager having an optical dome wherein the objective element covers the optical dome and is attached to the imager.

Telemetry System With out of Range Notification Features - An apparatus and method for notifying users of a telemetry device as they move out of the coverage area are provided. As the user of the telemetry device has moved out of the coverage area, the device notifies the user after attempting to establish a connection with the network for a predetermined time period, by transmitting an audio signal and/or displaying a visual signal.

INPUT OUTPUT DEVICE FOR USE WITH BODY MONITOR - A monitoring apparatus that includes a sensor device and an I/O device in communication with the sensor device that generates derived data using the data from the sensor device. The derived data cannot be directly detected by the associated sensors. Alternatively, an apparatus that includes a wearable sensor device and an I/O device in communication with the sensor device that includes means for displaying information and a dial for entering information. Alternatively, an apparatus for tracking caloric consumption and caloric expenditure data that includes a sensor device and an I/O device in communication with the sensor device. The sensor device includes a processor programmed to generate data relating to caloric expenditure from sensor data. Alternatively, an apparatus for tracking caloric information for an individual that utilizes a plurality of classification identifiers for classifying meals consumed by the individual, each of the classification identifiers having a corresponding caloric amount.

2008-11-06

20080275310

Apparatus for Monitoring Sweating State by Adjusting Temperature - Disclosed is an apparatus for monitoring a sweating state by adjusting skin and core temperatures, in which infrared ray heating means for raising the body temperature and cameras for photographing the sweating states of the upper and the lower part of the body of a person to be diagnosed are provided in a chamber so that the sweating states of the respective parts in accordance with the increase in the body temperature are photographed and are stored in a database and the sweating patterns are analyzed to simply and correctly diagnose the focus and the aching part of the person to be diagnosed. The apparatus includes a chamber in which a person to be diagnosed lies to be diagnosed, a temperature controller provided in the chamber to maintain the temperature of the chamber, body heating means provided in the chamber to emit infrared rays to the body and to raise the body temperature, body temperature sensors for detecting the core and the skin temperature of the body, cameras provided in the chamber to photograph the sweating pattern caused by an increase in the body temperature, a controller for sensing the body temperature of the person to be diagnosed and the temperature of the previously set temperature, and a computer for receiving the sweating pattern of the person to be diagnosed that is transmitted from the cameras to store, mange, and monitor the sweating pattern and for analyzing data on the body temperature of the person to be diagnosed and on the environments of the chamber that are received from the controller to control the controller to maintain the optimal environments. chamber to control the body heating means at a previously set temperature, and a computer for receiving the sweating pattern of the person to be diagnosed that is transmitted from the cameras to store, mange, and monitor the sweating pattern and for analyzing data on the body temperature of the person to be diagnosed and on the environments of the chamber that are received from the controller to control the controller to maintain the optimal environments.

2008-11-06

20080275311

Virtual Clinic For Medical Practice - A method is provided for a virtual clinic to establish communications between a user (e.g., a patient) and a specialist (e.g., a physician) in order to facilitate a diagnosis. In various embodiments, a user provides a request for the specialist to a virtual clinic. The request may be a request for medical services identifying medical needs. The user may then receive specialist information from the virtual clinic. The virtual clinic may establish real-time communication between the user and a specialist. The user may receive instructions from the specialist via the virtual clinic to perform a test. The user may then report a test result from the test to the specialist via the virtual clinic. The virtual clinic may receive and store a diagnosis from the specialist.

2008-11-06

20080275312

Cross-Band Communications in an Implantable Device - An ambulatory monitoring device includes a sensor to monitor a physiological signal and a battery power source. The device also includes a wireless receiver adapted to monitor a first frequency band having frequencies below 1 MHz and configured to detect and receive, using less than 10 micro-amps of current from the battery power source when operating, wireless communications within the first frequency band from a remote device at least one meter away. The device further includes a wireless transmitter adapted to transmit—after receipt from the remote device of a first wireless communication within the first frequency band that includes an invitation for further communication—a second wireless communication in a second frequency band having frequencies above 10 MHz, the second wireless communication comprising data indicative of the physiological signal as sensed by the sensor.

2008-11-06

20080275313

TRANSCUTANEOUS ANALYTE SENSOR - The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.

2008-11-06

20080275314

System and Process for Non-Invasive Collection and Analysis of Physiological Signals - A system and method for detecting, monitoring and analyzing physiological characteristics. Signals from a subject are acquired from a suite of sensors, such as temperature, carbon dioxide, humidity, light, movement, electromagnetic and vibration sensors, in a passive, non-invasive manner. The signals are processed and physiological characteristics are isolated for analysis. The system and method are to analyze sleep patterns, as well as to prevent bed sores or detect conditions such as illness, restless leg syndrome, periodic leg movement, sleep walking, or sleep apnea. However, numerous other applications of the invention are also disclosed.

2008-11-06

20080275315

Pigmentary Deposition Portion Remote Diagnosis System - A major object of this invention is to provide a remote diagnosis apparatus, a remote diagnosis system, a user terminal, a program, a diagnosis program, and a storage for easily diagnosing a pigmentary deposition portion. A user of the system picks up the skin having benign nevus pigmentosus that might be melanoma through a dermoscope using a portable telephone with a camera to which the dermoscope is attached by means of an adapter, accesses to the Internet using an Internet connection function of the portable telephone, and sends the picked up skin image to the remote diagnosis apparatus. After receiving the skin image, the remote diagnosis apparatus uses the melanoma diagnosis program to examine the skin image for melanoma and a disease stage of melanoma if there is melanoma and then sends a result to the user.

2008-11-06

20080275316

SKIN IMPEDANCE MATCHING SYSTEM AND METHOD FOR SKIN/ELECTRODE INTERFACE - The present invention relates to a system for measuring the input impedance of a skin/electrode interface and selectively modifying the input impedance of the monitoring circuit to match the measured input impedance. More particularly, a simplified method for correcting for input impedance mismatch between electronic monitoring circuitry and the skin/electrode interface. In accordance with one embodiment of the invention, an input impedance measuring circuit will interface with a microprocessor and a reconfigurable switch network to select the input impedance of the electronic monitoring circuitry, thus eliminating the impedance sensitivity of EMG or EKG instruments.

METHOD AND DEVICE FOR MEASUREMENTS IN BLOOD - We present an optical probe arrangement that surrounds blood in a receptacle. It comprises LED's and light detector arranged to overcome the variations when the receptacle is translucent medical tubing and the like. Also, a signal processing algorithm is used to average signals from a plurality of light detectors, to further enhance results when measuring hematocrit. The invention makes it possible to add the feature of hematocrit measurement into dialysis system without major alterations to the dialysis machine or transport tubing.

Optical sensor biosignal measurement apparatus and method of controlling optical sensor of the apparatus - An optical sensor biosignal measurement apparatus including an optical sensor having a luminous element to emit light towards the skin of a user and a photo detector to detect light from the skin of the user; a light quantity adjustment member to adjust an optical transmission area of the photo detector; and a light quantity controller to detect the quantity of light detected by the photo detector, and control the light quantity adjustment member to adjust the optical transmission area of the photo detector according to the quantity of light is provided.

2008-11-06

20080275323

METHOD OF MAKING AN ELECTROCHEMICAL SENSOR - A process for the manufacture of small sensors with reproducible surfaces, including electrochemical sensors. One process includes forming channels in the surface of a substrate and disposing a conductive material in the channels to form an electrode. The conductive material can also be formed on the substrate by other impact and non-impact methods. In a preferred embodiment, the method includes cutting the substrate to form a sensor having a connector portion and a transcutaneous portion, the two portions having edges that define one continuous straight line.

2008-11-06

20080275324

Fluid Access Interface - The present invention relates generally to systems, apparatuses, and methods for obtaining a fluid sample from a patient. In particular, the present invention relates to a various types of fluid access interfaces for enabling contact between a patient blood sample and blood parameter sensors for the measurement of physiological parameters and blood constituents.

2008-11-06

20080275325

Evanescent Catheter System - An evanescent catheter system is provided as a system having a structure of a tip portion of an optical fiber capable of securely measuring a fluorescence intensity or fluorescence spectrum of a substance around a catheter tip, without being hindered by optical absorption of hemoglobin in erythrocytes in blood, and being capable of calculating an existing amount of a fluorescence-emitting substance existing in an evanescent light generating part. A protecting layer

2008-11-06

20080275326

SENSOR FOR MONITORING A CONDITION OF A PATIENT - A sensor may include a substrate having a sensing portion defining a sensor thereon and a circuit mounting portion defining at least one electrically conductive pad that is electrically connected to the sensor. The sensor may be configured to produce a signal indicative of a condition of the patient. An anisotropic medium may be disposed on the circuit mounting portion and may be electrically conductive in a direction through the medium and electrically insulating in directions along the medium. An electrical circuit may be mechanically mounted to the circuit mounting portion of the first substrate via the anisotropic medium with at least one electrically conductive terminal juxtaposed over the at least one electrically conductive pad. The anisotropic medium may establish local electrical contact between the at least one electrically conductive terminal and the at least one electrically conductive pad.