I use WiiFlow 2.1 and USB Loader GX 2.0 and both seem to give me the same results: I can run Super Mario Galaxy 2 up until it asks me which savestate to load (the three planets which become a mii character's head) where suddenly, though my cursor is visible, I cannot select anything, nor can I return to the wii system menu (the light on my wiimote remains on, but no buttons seem to work). My system is NTSC and my ISO is PAL. Some of the cIOS files result in the remote turning off before I can press A+B to start the game.

Maybe it's my cIOS files?

Also, I was told that I don't need to block disc updates if running the file from a USB loader. Is this true in regards to SMG2?