Hours after Fittler put the pen through Luke Keary and Mitchell Pearce as halves options because of concussion and a groin injury respectively, the coach sat in his lounge room on the northern beaches and watched Reynolds last just 33 minutes for the Rabbitohs at ANZ Stadium.

Reynolds looked ready to claim the No.7 jersey for the Blues after showing a wonderful turn of foot to race away for a try against the Wests Tigers.

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The heavily inked father of four played two Origin games in 2016 and was looming as the best option on Wednesday week alongside Souths teammate Cody Walker.

But Reynolds reeled in pain as Mark Nicholls rushed over to complete a tackle on Tigers' livewire Corey Thompson.

Only a few tackles earlier Reynolds had taken his time to get back into the defensive line as he clutched his jaw and appeared to wipe blood from his mouth.

Reynolds will head for X-rays on Sunday morning, but the look on his face as he sat in the stands with an ice-pack on his leg told the story.

"It's a lower leg injury, they're not sure what it is at the moment; it's somewhere around the calf area, there could be a fracture,'' Souths coach Wayne Bennett said.

Another Blues casualty: Adam Reynolds receives attention from a trainer before hobbling from the field.Credit:AAP

"Who was to know if he was going to be picked or not [for NSW]. I'm feeling for South Sydney. We need him to play if we can, if he can't we'll get it done until he's back.

"He was playing great tonight and he's been very good every week. He's had injuries before in football. He's fine.''

The injury to Reynolds will virtually cost Walker his Origin dream given the pair were seen as a package deal.

Penrith's Nathan Cleary and James Maloney are the incumbents and now seemingly ready to retain their all-important gig by default.

Happy days: Cameron Murray celebrates with Junior Tatola after scoring against the Tigers.Credit:AAP

Bennett would have been bracing for Reynolds, Walker, Damien Cook and Cameron Murray, as well as Queensland outside back Dane Gagai, to be dragged away for Origin duty and unavailable for Friday's road trip to Parramatta.

The Rabbits sit on top of the ladder with 10 wins from 11 starts after their 32-16 win over the Wests Tigers. It is their best start to a year since 1989 when they won the minor premiership.

But Bennett will struggle to field a side against the Eels, especially given the club could not find 21 fit players to put on the official team sheet at the start of the week.

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Cook and Gagai will definitely take part in Wednesday week's state-versus-state opener, while Murray, who bagged two tries against the Tigers, is at skinny odds to make his debut off the bench for the Blues.

Murray is an absolute gun who will relish the challenge of taking the fight to the Maroons.

"He's been good every week and he hasn't had a bad game,'' Bennett said of the young lock forward.

"It's quite remarkable the size of him and the work he gets through and the way he carries the ball and things he does. He's always around the ball. He'd be close to Origin selection, I've got no doubt about that.''

Murray was put across the line by Cook after 15 minutes of play against the Tigers. His offload a few moments earlier had the Tigers on the back foot and allowed Reynolds to slot an easy penalty goal.

When Reynolds raced a short distance to score a try and make it 14-0, the Tigers looked headed for a heavy defeat.

Even though they had little possession, and were on the end of a 7-2 first-half penalty count, the Tigers refused to give up.

Loose carry: Sam Burgess coughs up the ball at ANZ Stadium.Credit:AAP

Luke Brooks forced a dropout, then the Tigers registered points on the next set as Benji Marshall threw a lovely inside ball for a fleet-footed Corey Thompson.

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Thompson filled in at fullback for the injured Moses Mbye and was causing all sorts of drama.

Tigers coach Michael Maguire said Mbye had only tweaked his groin and would be fine if picked for Queensland.

As for persevering with Thompson long-term in the No.1 – which would require the skipper to play elsewhere –Maguire said: "Moses has been doing some good things out the back for us, and a lot of people don't understand the fullback position as a defender.

"They're corralling and telling people where to go.

"Moses has a great ability to do that, and his attack the last few weeks has started to rise. I'll have a look at it and assess which way we want to go.''