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Miles was born in Caloocan, Philippines, to Victorino Sandel and Maria Perla Santos. She was the third child of the couple's four children.

At 16 years old, Miles starred in GMA sitcoms Beh Bote Nga and German Moreno's Best Friends. Between showbiz assignments, Miled joined beauty pageants which provided her with a steady income. She finished her secondary education at La Consolacion Caloocan.[citation needed] While a sophomore at University of Santo Tomas' Conservatory of Music, where she majored in voice and minored in piano, film producer Dondon Monteverde signed her up to an eight-film, two-year contract with Regal Films.

Her debut role was a provincial prostitute in the movie Prosti. Highly successful at the box office, the film grossed ₱29 million. To date, Prosti remains her highest grossing movie. The success in the titular role led to other movie offers, as well as product endorsement deals from companies such as Bench (a clothing company in the Philippines).

After Prosti, Miles starred in the movie Xerex (based on a tabloid sex advice column), where she played three different roles. Miles' next movie, Sanib, saw her play a character who is possessed by demons.

Targeting multi-media exposure, Miles' manager secured her a contract with the ABS-CBN television network. She appeared as co-host of the daily noontime show Masayang Tanghali Bayan, and in several ABS-CBN sitcoms. As part of a strategy to build wider appeal, Miles also began appearing in more family friendly movie roles, in films like Sanib, A Beautiful Life, and Gagamboy – Regal Film's 2003 Metro Manila Film Festival entry – as actor Vhong Navarro's love interest.

Miles has three times appeared on the cover of FHM Philippines; she was a covergirl in 2002, 2004 – depicted covered in gold-paint for the magazine's 50th issue (it was "revived" in 15th anniversary of FHM in March 2015, portrayed by Fil-Malay model Nicole Alexandria) , and in 2009.[1] Miles was also one of three FHM Calendar Girls along with Maui Taylor and Diana Zubiri for the FHM 2003 calendar.

Teaming up with real-life best friend Jacqueline Yu, Miles was a contestant in The Amazing Race Asia 1. They finished in 9th place out of the 10 teams.