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Air Corps 112 was sent out to the incident to airlift one woman to hospital.

It is understood one of the women involved is pregnant.

An onlooker said two of those involved were travelling in one car.

The road was closed this morning and afternoon in both directions and local diversions were in place.

N20 crash (Image: David O'Toole)

A Garda spokesperson told the Irish Mirror: “Gardai are currently at the scene of a two vehicle road traffic collision, which occurred on the 29th Dec 2016 on the N20, 1 km north of Buttevant, Co Cork (Charleville side).

“A female was airlifted to hospital (unknown at present) with injuries unknown. The road remains closed for technical examination. Investigations are ongoing.”

This is the second major crash to take place on the N20 this month after a tragedy earlier this month.

Cork crash (Image: David O'Toole)

Mandy O'Leary, 29, was travelling on the N20 Cork-Limerick road when her car left the road at Clogheenmilcon on December 2.