Individuals with a history of an allergic reaction to the
penicillins. It is also contraindicated in patients with a history
of amoxicillin associated hepatic dysfunction of jaundice.

Adverse Effects:

Sensitivity reactions are more likely to occur in individuals who
have previously demonstrated hypersensitivity to penicillins and in
those with a history of allergy, asthma, hay fever or urticaria.
The hypersensitivity reactions are Erythematous maculopapular
rashes, urticaria, fever and joint pains. Anaphylactic shock may
occur. Gastrointestinal :diarrhoea, nausea, vomiting, heartburn,
pseudomembranous colitis Liver: A moderate rise in serum glutamic
oxalacetic transaminase has been noted, but the significance of
this finding is unknown. Haemic and Lymphatic Systems: Anemia,
thrombocytopenia, thrombocytopenic purpura, eosinophilia,
leukopenia and granulocytopenia have been reported during therapy
with penicillins. These reactions are usually reversible on
discontinuation of therapy and are believed to be hypersensitivity
phenomena. Central Nervous System: Reversible hyperactivity,
agitation, anxiety, confusion, behavioural changes and/or
dizziness.

Drug Interactions:

This product is synergistically active with aminoglycoside with
balanced dosages and it also shows a good synergistic effect with
TMP. If employed together with benemid, tubular secretion will be
decreased, serum concentration of amoxicillin will go up and half
life extend. Chloromycetin, macrolides, sulfa and tetracycline will
interfere the product’s antibacterial activity. Amoxicillin must
not be employed together with vitamin C and sodium bicarbonate.

Precautions & Warning:

Hypersensitivity reactions: Erythrematous maculopapular rashes,
urticaria, erythema multiforme and exfoliative dermatitis. Whenever
such reactions occur, Amoxicillin should be discontinued. Hepatic:
A moderate rise in AST has been noted, but the significance of this
finding is unknown. Haematologic: Reactions such as anaemia,
thrombocytopenia, thrombocytopenic purpura, eosinophilia,
leucopenia and agranulocytosis have been reported during therapy
with other penicillins. These reactions are usually reversible on
discontinuation of therapy and are believed to be hypersensitivity
phenomena.

Use in Pregnancy and Nursing Mothers:

Animal reproduction test shows, 10 times of the human dose of
amoxicillin don’t damage the fertility and fetal of rats and mice.
But it is still lack of adequate study for human. As animal
reproduction test can not fully predict the human response,
pregnant women will not use it except necessary. As breast milk can
secrete little amoxicillin, so it may cause infant allergies .

Treatment/antidote in The Event of Overdose:

There is a forward-looking studies which involved in 51 pediatric
patients shows that when The amoxicillin dosage does not exceed
250mg/kg, it will not cause significant clinical symptoms. It’s
reported that minority patients have renal insufficiency, oliguria
after overdose, but renal dysfunction is reversible when stop to
use it.

Storage instructions:

Store below 25℃. Protect from moisture. Keep out of reach of
children.