Target

Gene ID

Gene Symbol

Molecular Weight

106.6 kDa

Database Links

Alternative Names

DDX58Probable ATP-dependent RNA helicase DDX58 DDX58

Function

Innate immune receptor which acts as a cytoplasmic sensor of viral nucleic acids and plays a major role in sensing viral infection and in the activation of a cascade of antiviral responses including the induction of type I interferons and proinflammatory cytokines, Its ligands include: 5'-triphosphorylated ssRNA and dsRNA and short dsRNA (<1 kb in length), In addition to the 5'-triphosphate moiety, blunt-end base pairing at the 5'-end of the RNA is very essential, Overhangs at the non-triphosphorylated end of the dsRNA RNA have no major impact on its activity, A 3'overhang at the 5'triphosphate end decreases and any 5'overhang at the 5' triphosphate end abolishes its activity, Upon ligand binding it associates with mitochondria antiviral signaling protein (MAVS/IPS1) which activates the IKK-related kinases: TBK1 and IKBKE which phosphorylate interferon regulatory factors: IRF3 and IRF7 which in turn activate transcription of antiviral immunological genes, including interferons (IFNs)