Cerebral vascular control and muscle pH in CFS

Apologies if this has been posted before, but I couldn't find it here, and have only just seen the paper myself. It's by Julia Newton and colleagues and was submitted by them in 2012. There was no control group and they used the Fukuda case definition criteria. Interesting though.

Cerebral vascular control is associated with skeletal muscle pH in chronic fatigue syndrome patients both at rest and during dynamic stimulation ☆

b Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, United Kingdom

Abstract
Cerebral blood flow (CBF) is maintained despite changing systemic blood pressure through cerebral vascular control, with such tight regulation believed to be under local tissue control. Chronic fatigue syndrome (CFS) associates with a wide range of symptoms, including orthostatic intolerance, skeletal muscle pH abnormalities and cognitive impairment. CFS patients are known to have reduced CBF and orthostatic intolerance associates with abnormal vascular regulation, while skeletal muscle pH abnormalities associate with autonomic dysfunction. These findings point to autonomic dysfunction as the central feature of CFS, and cerebral vascular control being influenced by factors outside of the brain, a macroscopic force affecting the stability of regional regulation. We therefore explored whether there was a physiological link between cerebral vascular control and skeletal muscle pH management in CFS.

To examine dynamic control, brain functional MRI was performed concurrently with Valsalva manoeuvre (VM), a standard autonomic function challenge, while 31P-MRS was performed during plantar flexion exercise.

Apologies if this has been posted before, but I couldn't find it here, and have only just seen the paper myself. It's by Julia Newton and colleagues and was submitted by them in 2012. There was no control group and they used the Fukuda case definition criteria. Interesting though.