Drew Barrymore wants her friends to tell her like it is -- even when the truth hurts.

Drew, 41 -- who confirmed earlier this month that she and third husband Will Kopelman are divorcing -- spoke about how her best friend and film business partner of 21 years, Nancy Juvonen (who's married to late-night host Jimmy Fallon), always keeps it real.

"I'd go to her about relationship advice and I'd be like, 'I just don't understand why this keeps happening! ... I mean, this is exactly what happened last time. It's just like every single time,'" Drew said during a Q&A with Good Housekeeping's editor-in-chief Jane Francisco in New York City on April 19, as reported by Us Weekly.

"She's like, 'I did notice that there's a common denominator problem in all of your relationships and I'd like to identify it right now,'" Drew added. "And I'm like, 'What!? I've been waiting! Show me the light!'"

"She's like, 'It's you.'"

Drew stayed mum on other details and didn't reveal if Nancy told her this in reference to her latest failed relationship or another one. (Drew was famously married to bar owner Jeremy Thomas in 1994, comedian Tom Green in 2001, and enjoyed high-profile romances with The Strokes drummer Fabrizio Moretti and actor Justin Long before saying "I do" with Will in 2012.)

Drew and Will announced the end of their nearly four-year marriage, which produced two daughters -- Olive, 3, and Frankie, 2 -- after days of speculation by multiple media outlets earlier this month.

A source told Page Six, "There was no cheating involved. Drew gave that relationship everything. She is all about family . . . She would do anything to maintain and fight for it because she wanted [a husband and kids] so badly. She did everything for that."

The source added, "[Will] always wanted things his way. They're complete opposites. She's more of a free spirit and he's more buttoned-up."

As the keynote speaker at a luncheon for the New York Society for the Prevention of Cruelty to Children, the actress and producer read from her 2015 memoir, "Wildflower," which details her experience building a school in Kenya.

Although Will, an art consultant, features prominently in the 17-page chapter from which she read, Drew opted to skip over those sections, perhaps in an effort to keep the audience focused on the charity organization's goals rather than on her split.

According to Page Six, Drew began her speech by saying, "As you women know, laughter and crying are twins," before joking, "you men are still struggling with that."