靶标

功能

Plays a role in replication-dependent histone mRNA degradation at the end of phase S. Part of a post-splicing multiprotein complex. Involved in nonsense-mediated decay (NMD) as part of the SMG1C complex, a mRNA surveillance complex that recognizes and degrades mRNAs containing premature translation termination codons (PTCs). The complex probably acts by associating with ribosomes during tranlation termination on mRNPs. If an exon junction complex (EJC) is located 50-55 or more nucleotides downstream from the termination codon, RENT1 is phosphorylated by SMG1, triggering nonsense-mediated decay (NMD). Essential for embryonic viability.

Thank you for contacting us.
While we do carry a number of anti-hUPF1 antibodies which have been generated using immunogens near the C-terminus, the epitope for ab109363 is generated from a region near the N-terminus.
A number of our other anti-...

Thank you for contacting Abcam about ab109363, ab92655 and ab10534.
Unfortunately the immunogen sequences for these three antibodies is proprietary information and I do not have access to that information.
Please except my apologies for n...