The Latics - who also shocked Man City in last year’s FA Cup Final with a 1-0 win at Wembley - upset their more illustrious opponents again to set up a semi-final showdown with Arsenal next month.

As well as ruining their Quadruple quest, City’s defeat also ended their hopes of becoming the first English side to complete the domestic treble of the League, FA Cup and League Cup in the same season.

Going out of two competitions in four days would be a major blow to Manuel Pellegrini's men, who also trail Premier League leaders Chelsea by nine points - albeit with three games in hand.

Although City have already lifted the Capital One Cup, a season which held such promise would be viewed as a failure if that was the only trophy secured by the big-spending and ultra-ambitious club.

Nasri, who scored the consolation goal in Sunday’s defeat to Wigan, wants Pellegrini’s side to take out their anger on Barcelona and stage an heroic display in the Nou Camp to advance against the odds.

“We have to do everything from the start,” said Nasri. “The Nou Camp is always something special.

“It’s a special feeling to play there. It’s going to be difficult, but I know if we play at our level we can do something. Let’s have high hopes, forget about the game against Wigan and we will see.

“We have nothing to lose. If you go there and you lose, it’s no more, but if you get a result it will be fantastic. We have to just attack them from the start and try to score an early goal. That would worry them, so we will see.

“We feel hung-over. It was a bad performance against Wigan and we didn’t play well. It’s the FA Cup, they gave it us on a plate [those who did the draw] and we refused to take it.

“I really don’t know. I can’t find the words because I’m really disappointed. The main disappointment is that it’s twice now that Wigan have beaten us in the FA Cup. It’s really difficult to accept.

“Thank God we play a big game on Wednesday. It’s the best way to forget this game and be focused on the next one.

“It’s going to be a big game. We’re going to think about Barcelona, we need to be positive and get a result there. A game like this, you cannot not be focused from the start. It’s an amazing game and we can do something fantastic if we change the result.