Drug Interactions With Diclofenac/Misoprostol

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Diclofenac/misoprostol can decrease the effectiveness of diuretics. Talk to your healthcare provider before taking these drugs together.

Lithium

Taking diclofenac/misoprostol and lithium together may increase the levels of lithium in your blood. Your healthcare provider may need to monitor you more closely and adjust your lithium dosage if you take these medicines together.

"Blood Thinners" and Other Similar Drugs

Combining diclofenac/misoprostol with anticoagulants, antiplatelet drugs, or other medications that increase the risk for bleeding may lead to serious bleeding problems, including dangerous internal bleeding. Do not take these medicines together without first talking to your healthcare provider.

Methotrexate

Diclofenac sodium may increase the risk of methotrexate toxicity. Do not combine these medications without your healthcare provider's supervision and approval.

Oxytocin

Oxytocin is a medication used to stimulate labor by causing contractions. Diclofenac/misoprostol contains misoprostol (Cytotec®), a medicine that can also cause uterine contractions. Taking these drugs together may increase the effects of oxytocin on the uterus.

Pemetrexed

Diclofenac/misoprostol may increase pemetrexed blood levels, which could increase your risk for side effects. Your healthcare provider will monitor you more closely if you take these medicines together. If you have kidney disease, your healthcare provider may recommend you avoid taking diclofenac/misoprostol two to five days before, the day of, and two days after you receive pemetrexed.

SSRIs or SNRIs

Combining a selective serotonin reuptake inhibitor (SSRI) or a serotonin-norepinephrine reuptake inhibitor (SNRI) with diclofenac/misoprostol may increase the risk of GI bleeding. Check with your healthcare provider before taking diclofenac/misoprostol with one of these drugs.

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