People with multiple sclerosis (MS) are associated with an increased risk of cardiovascular disease and mortality; however, evidence from population-based studies is sparse. The objective of this study was to assess whether the risk of macrovascular events and mortality differs among people with MS compared with a matched population without MS in England. A total of 12 251 people with MS were matched with 72 572 people without MS. As compared with people without MS, people with MS were associated with a 28% increased hazard of acute coronary syndrome, 59% increased hazard of cerebrovascular disease, 32% increased hazard of any macrovascular disease, 3.5-fold increased hazard of all-cause mortality, and 1.5-fold increased hazard in cardiovascular disease mortality. Differences in macrovascular events were more pronounced among women than men. Mortality risk was also higher for women than men. Treatment with lipid-lowering medications (mainly statins) was associated with lower mortality rates among people with MS.Conclusivey, This study suggests that MS is associated with an increased risk of cardiovascular and cerebrovascular disease that is not completely accounted for by traditional vascular risk factors. Given the adverse effects of these comorbidities on outcomes in patients with MS, further investigation is needed.Source: https://jamanetwork.com/journals/jamaneurology/article-abstract/2765472