Abstract : In this paper a sensitivity analysis of trajectories w.r.t. wind effects is proposed. This analysis will allow to specify wind estimates properties as well as control reactiveness characteristics to ensure accurate guidance in real atmosphere. The mathematic model developed for flight dynamics is intended to take into account wind gust effects on AoA, sideslip angle and airspeed. A two layer Nonlinear Dynamic Inversion (NDI) structure has been considered to control fast and slow dynamics. In order to test the proposed approach, a full six degrees of freedom Matlab model with trained Neural Networks to emulate a Boeing 737-200 was developed.