Doty is perhaps best known for having invented the University of Pennsylvania Smell Identification Test or UPSIT[2] (commercially known as the Smell Identification Test), the first widely used standardized olfactory test. The UPSIT has been administered to an estimated half million persons since its introduction in the 1980s and has been translated into 13 different languages. This test has been heralded as the olfactory equivalent to the eye chart.