Further study details as provided by University Hospital Case Medical Center:

Primary Outcome Measures:

modified Rush Video Rating Scale (mRVRS)

at defined points including baseline and 3 months

Secondary Outcome Measures:

tic counts (on video recording)

Yale Global Tourette Severity Scale (YGTSS)

Tourette Syndrome Symptom List (TSSL)

Quality of Life Visual Analog Scale (VAS)

SF-36

Neuropsychological battery

Estimated Enrollment:

5

Study Start Date:

June 2005

Eligibility

Ages Eligible for Study:

18 Years and older

Genders Eligible for Study:

Both

Accepts Healthy Volunteers:

No

Criteria

Inclusion Criteria:

age 18 or older

Diagnosis of Tourette Syndrome by DSM-IV

Tic frequency at least one per minute at screening

prior failure of at least two dopamine receptor or presynaptic blockers

negative impact on quality of life

Exclusion Criteria:

significant structural brain lesion (on imaging studies)

significant dementia

severe head trauma preceding onset of tics

use of dopamine receptor blockers prior to recognition of tics

prior implanted electrical device

electroconvulsive therapy (ECT) within 24 months

suicide attempt within 12 months

significant sociopathic personality

current or planned pregnancy

Contacts and Locations

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study.
To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below.
For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00311909