cancer. Specifically, individuals with a primary thyroidcancer have a high incidence of second primary cancers even after adjusting for surveillance bias. One study of a cohort of 39 002 research participants suggested that when compared to the general

. 2013 , Pyne & Pyne 2013 , Takabe & Spiegel 2014 ).
The importance of sphingolipids in thyroidcancer has not been studied in great detail. We have shown that S1P is without an effect on the proliferation and invasion of normal thyroid cells but

Weijun Wei, Heather Hardin and Quan-Yong Luo

Introduction
Thyroidcancer is the fifth most common cancer in women in the United States and is the most commonly diagnosed cancer before the age of 30 years among women in China ( Chen et al. 2016 ). Although thyroidcancer is generally

Carles Zafon, Joan Gil, Beatriz Pérez-González and Mireia Jordà

Introduction
Thyroidcancer, the most prevalent endocrine malignancy, covers the full range of phenotypes from indolent to the worst forms of human cancer. It is categorized into differentiated thyroidcancer (DTC), poorly differentiated

M Xing

Introduction
Thyroidcancer is the most common endocrine malignancy. It can be classified histologically into follicular epithelial cell-derived papillary thyroidcancer (PTC), follicular thyroidcancer (FTC), anaplastic thyroid

Zhenying Guo, Heather Hardin and Ricardo V Lloyd

Introduction Thyroidcancer is one of the most rapidly increasing malignancies in the USA ( Siegel et al . 2013 ). Although most well-differentiated thyroidcancers have a good prognosis, a small percentage of these tumors are associated with

Hao Fu, Lin Cheng, Yuchen Jin and Libo Chen

thyroid carcinoma. With globally rising incidence, thyroid carcinoma has attracted much more concern than before.
In theory, thyrotoxicosis with suppressed TSH should lead to a lower incidence of thyroidcancer than that observed in euthyroid patients