12h à 13h30

Abstract: Cerebellar ataxias are not well treated. Here we identify enhanced mGluR1 signalling at cerebellar synapses in the early, pre-symptomatic stages of SCA1 using Purkinje neuron specific and inducible overexpression of ataxin-1 CAG repeats. Mild pharmacological moderation of mGluR1 restored motor learning in SCA1 mice and could provide a potential lead for treatment of the early stages of ataxia.