The purpose of this study is to examine the neuropsychological effects of transvascular aortic valve implantation (TAVI). Patients undergoing TAVI usually suffer from congestive heart failure and low cardiac output which may limit their cognitive abilities. TAVI results in significant improvements in cardiac function and therefore may improve cognitive functions. However, TAVI may also be associated with stroke and may therefore have a negative impact on cognition. Therefore, in this study the investigators wish to perform a battery of standardized neuropsychological tests before and after TAVI to test the net effects of TAVI on cognitive performance over time.

The investigators plan to include all patients planned to have TAVI in the study and to test them before, 3,7, 30 and 360 days post TAVI with a standardized battery of test.

patients with significant aortic stenosis that are candidates for transvascular aortic valve implantation

Other: Neuropsychological testing

This is an observational study

Eligibility

Ages Eligible for Study:

60 Years and older

Genders Eligible for Study:

Both

Accepts Healthy Volunteers:

No

Sampling Method:

Non-Probability Sample

Study Population

All patients with severe aortic stenosis that are candidates for TAVI

Criteria

Inclusion Criteria:

All patients with severe aortic stenosis that are candidates for TAVI

Able to perform the testing

Able to sign informed consent

Exclusion Criteria:

Language barriers precluding the administration of the testing

Existing dementia

Existing disease limiting life expectancy to less than 180 days

Contacts and Locations

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study.
To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below.
For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01648309