Diseases and Conditions

Peyronie's Disease

What is Peyronie's disease?

Peyronie's disease is characterized by a plaque, or hard lump, that forms on the erection tissue of the penis. The plaque
often begins as an inflammation that may develop into a fibrous tissue.

Peyronie's disease was first described in 1743 by a French surgeon, François de la Peyronie. It was classified as a form of
impotence. However, now impotence is recognized as one factor associated with Peyronie's disease, but it is not always present.

What causes Peyronie's disease?

Some researchers believe Peyronie's disease develops following a trauma that causes bleeding inside the penis. This trauma
may explain acute cases of Peyronie's disease, but does not explain why most cases develop slowly, or what causes the disease
after no apparent traumatic event.

Generally, when the disease heals within a year or so, the plaque does not advance beyond an initial inflammatory phase. However,
when the disease lasts for years, the plaque often becomes a tough, fibrous tissue, and calcium deposits may form.

What are the symptoms of Peyronie's disease?

The plaque in Peyronie's disease is benign, or noncancerous. The following are the most common symptoms of Peyronie's disease.
However, each individual may experience symptoms differently. Symptoms may include:

Plaque on the top of the shaft, which is the most common condition, causes the penis to bend upward.

Plaque on the underside causes the penis to bend downward.

In cases where the plaque develops on both top and bottom, indentation and shortening of the penis may occur.

The symptoms of Peyronie's disease may resemble other conditions or medical problems. Always consult your doctor for a diagnosis.

How is Peyronie's disease diagnosed?

A diagnosis of Peyronie's disease is usually made when men seek medical attention for painful erections and difficulty with
intercourse. In addition to a complete medical history and physical examination, diagnostic procedures for Peyronie's disease
may include the following:

Ultrasound examination of the penis. A diagnostic technique that uses high-frequency sound waves to create an image of the internal organs.

Color Doppler examination. A type of ultrasound that uses sound waves to measure the flow of blood through a blood vessel; waveforms of the blood flow
are shown on the ultrasound screen (to evaluate erectile function, anatomy, and blood flow).

What is the treatment for Peyronie's disease?

Specific treatment for Peyronie's disease will be determined by your doctor based on:

Your age, overall health, and medical history

Extent of the disease

Your tolerance for specific medications, procedures, or therapies

Expectations for the course of the disease

Your opinion or preference

In general, the goal of treatment is to keep the patient with Peyronie's disease sexually active. Providing education about
the disease and its course is often included in the treatment plan. In some cases, treatment is not necessary, as Peyronie's
disease often occurs in a mild form that heals without treatment in six to 15 months. Treatment may include:

Prescribing or continuing palliative methods

Surgery

Vitamin E. Small studies have reported improvements with oral vitamin E prescribed by a doctor; however, larger controlled studies have
not been completed to establish the effectiveness of this treatment.

Injections of various chemical agents into the plaques. Injections of various chemical agents into the plaques have been utilized in a small number of patients, and, for this reason,
this intervention is considered unproven; unwanted side effects may occur.

Radiation therapy. With this treatment approach, radiation is aimed at the plaque to reduce pain, but does not affect the plaque itself; unwanted
side effects or worsening of the disease may occur.

Please consult your doctor with any questions or concerns you may have regarding this condition.