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Abstract

The most important problem in the analysis of time-sequences is the
compensation for artefactual motion. Due to motion, medical images of
the abdominal region do not represent organs with fixed configuration.
Analysis of organ function with dynamic contrast media studies using
regions of interest (ROI) is thus not readily accomplished. Images of
the organ of interest need to be registered and corrected prior to a
detailed local analysis.
We have developed an image analysis scheme which allows the automatic
detection of the organ contours, the extraction of the motion
parameters per frame and the registration of images. The complete
procedure requires only minimal user interaction and results in a
readjusted image sequence, where organs of interest remain fixed.
Both, a visual analysis of the dynamic behavior of functional
properties, such as a quantitative statistical analysis of signal
intensity versus time within local regions-of-interest, is
considerably facilitated using the corrected series.