Clinical, clinicopathological and image data from Malawian children shows that sequestration in P. falciparum cerebral malaria is visible clinically in the eye as orange retinal vessels and is strongly associated with death.

Fevers amongst African children are often assumed to be caused by a malaria infection, but here it is estimated that the majority of fevers amongst African children, including those with a patent malaria infection, are due to infections with diseases other than malaria.

Insights into the basic metabolic architecture and adaptations of malaria parasites for growth within human erythrocytes exemplify how incisive knowledge of biochemical pathways and mechanisms may be leveraged to develop new therapies.

Under sustained malaria control in PNG, the incidence of distinct blood-stage infections quantifies heterogeneity in transmission, significantly predicting risk of both P. falciparum and P. vivax malaria episodes at a population and individual scale.

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