Yes, we know on a supernatural show, death is inevitable and not always meaningful, but Graham says this one will stick. "It's actually one of the biggest deaths since the beginning of The Vampire Diaries," Graham says. "It'll change the nature of the series; it'll change the nature of the characters going forward; it'll change the dynamic; it will completely alter everything."

Will one of the Salvatore brothers actually kill the other? Will Klaus betray his love Caroline and stake her? Will Jeremy lose a battle as the Hunter? Will Bonnie's magic once and for all be too much for her body to take? Share your theories below and vote in our poll!