In vitro susceptibility testing of dermatophytes with itraconazole by disk diffusion

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PV Venugopal, TV. Venugopal

ABSTRACT: In vitro susceptibility testing of 43 clinical isolates of dermatophytes was carried out against itraconazole by agar dilution and disk diffusion methods. The results were compared with that of ketoconazole. Itraconazole was more active, inhibiting 90 percent of the isolates (MIC 90) at a concentration of 0.5 ug/ml (MIC range 0.01-5 ug/ml) required 1 and 2.5 ug/ml for inhibiting 50 and 90 percent of the isolates. The MIC values and the sizes of zones of inhibition correlated well for both the drugs. Regression analysis was used to measure the degree of correlation between the MIC values and matched averaged zones of inhibition and the correlation coefficients for itraconazole and ketoconazole were - 0.4225 (P0.01) and - 0.5886 (P0.001) respectively.

ABSTRACT: Mental sweating is often associated with deep seated emotional disturbances. Three such patients having palmo-plantar hyperhidrosis who were unsatisfied after trying our most of the available modalities of treatment were teated with autohypnotherapy on a trial basis. All the three patients improved.

ABSTRACT: We report a family where 7 members in three successive generations were affected with lichen amyloidosis. Histopathology of the lesion with special stain for amyloid and polaroscopic examinations confirmed the diagnosis. Primary localized cutaneous amyloidosis is not an uncommon entity. Familial forms are however, very rare 1, and there have been only few case reports in the literature where more than one member of the family was affected 2-4.

ABSTRACT: A case of Bowen's disease of the periareolar skin causing destruction of the nipple is reported. There was no history of chronic arsenicalism and no evidence of underlying visceral malignancy.