anti-Serine/threonine-Protein Kinase PRP4 Homolog (PRPF4B) Antibodies

Pre-mRNA splicing occurs in two sequential transesterification steps, and the protein encoded by PRPF4B is thought to be involved in pre-mRNA splicing and in signal transduction. Additionally we are shipping Serine/threonine-Protein Kinase PRP4 Homolog Proteins (6) and many more products for this protein.

PRP4K is novel estrogen regulated kinase, and its levels can be reduced by 4-OHT in ER+ breast cancer cells altering their response to taxanes

PRP4K functions as a HER2 (show ERBB2 Antibodies)-regulated modifier of taxane sensitivity and is a prognostic biomarker for better survival in taxane-treated ovarian cancer patients. PRP4K knock-down results in "mitotic slippage" in response to taxanes, and reduced PRP4K expression is associated with both intrinsic and acquired resistance of ovarian and breast cancers to taxanes.

The p.R192H variant of PRPF4 (show PRPF4 Antibodies) represents a functional null allele which compromises the function of the tri (show VANGL2 Antibodies)-snRNP (show LSM2 Antibodies), reinforcing the notion that this spliceosomal particle is of crucial importance in the physiology of the retina.

Serine/threonine-Protein Kinase PRP4 Homolog (PRPF4B) Antigen Profile

Protein Summary

Pre-mRNA splicing occurs in two sequential transesterification steps, and the protein encoded by this gene is thought to be involved in pre-mRNA splicing and in signal transduction. This protein belongs to a kinase family that includes serine/arginine-rich protein-specific kinases and cyclin-dependent kinases (CDKs). This protein is regarded as a CDK-like kinase (Clk) with homology to mitogen-activated protein kinases (MAPKs).