..Taken together, microRNA activity may be controlling many of the cellular mechanisms already known to be involved in the development of alcoholism, and suggests potential targets for the development of novel therapeutic interventions...

..In the present study, we tested the hypothesis that these phenotypes are represented by differential production of the inducible transcription factor, ΔFosB, in reward, aversion, and stress related brain regions...

..These results suggest that D2R-induced up-regulation of DAT activity occurs via a voltage-independent mechanism that depends on G(i/o) activation and a rapid increase in expression of functional DAT molecules at the cell surface...

Ethanol potentiates the function of the human dopamine transporter expressed in Xenopus oocytes

..Heavy alcohol use results in brain damage that is generally more severe in cirrhotic compared with noncirrhotic alcoholics. We examined, at the cellular level, gene expression in the frontal cortex of cirrhotic alcoholics...

..The finding that the expression level of differentially expressed proteins is preponderantly lower in the alcoholic brain is supported by recent results from parallel studies using microarray mRNA transcript...

Research Grants6

..Third, the DAT proteome has not been studied, and defining this important complex will be an innovative accomplishment which should have wide ranging significance for other areas of neurobiology and addiction research. ..

..Third, the DAT proteome has not been studied, and defining this important complex will be an innovative accomplishment which should have wide ranging significance for other areas of neurobiology and addiction research. ..

..Third, the DAT proteome has not been studied, and defining this important complex will be an innovative accomplishment which should have wide ranging significance for other areas of neurobiology and addiction research. ..