Report on the establishment of an engineered CHOS cell line that has been engineered to express both XBP-1S) and ERO1-Lalpha and has been named CHOS-XE. CHOS-XE cells produced increased antibody (MAb) yields (5.3- 6.2 fold) in comparison to CHOS cells.

ER stress induced by misfolded proinsulin (show INS Proteins) was limited by increased expression of Ero1alpha, suggesting that enhancing the oxidative folding of proinsulin (show INS Proteins) may be a viable therapeutic strategy in the treatment of type 2 diabetes.

These results suggest that overexpression of ERO1-alpha in the tumor inhibits the T cell response by recruiting polymorphonuclear myeloid-derived suppressor cells

ER stress induced by misfolded proinsulin (show INS Proteins) was limited by increased expression of Ero1alpha, suggesting that enhancing the oxidative folding of proinsulin (show INS Proteins) may be a viable therapeutic strategy in the treatment of type 2 diabetes.

Oxygen regulation of ERO1-Lalpha expression likely maintains the transfer rate of oxidizing equivalents to PDI (show PDIA3 Proteins) in situations of an altered cellular redox state induced by changes in the cellular oxygen tension

Data suggest that ERp44 (show ERP44 Proteins) and Ero1-lalpha play a major role in the assembly of higher-order adiponectin (show ADIPOQ Proteins) complexes, and highlight the importance of posttranslational events controlling adiponectin (show ADIPOQ Proteins) levels and the release of adiponectin (show ADIPOQ Proteins) from adipocytes.

These data shed new light on how the CHOP (show DDIT3 Proteins) pathway of apoptosis triggers calcium-dependent apoptosis through an ERO1-alpha-IP3R (show ITPR1 Proteins) pathway.

Pig (Porcine) ERO1-Like (S. Cerevisiae) (ERO1L) interaction partners

Tissue distribution analysis of Ero1L and ERp44 (show ERP44 Proteins) genes revealed extremely high expression in adipose tissue, and the topology of their phylogenic tree indicates a high degree of conservation among different species.

ERO1-Like (S. Cerevisiae) (ERO1L) Protein Profile

Protein Summary

This gene encodes a member of the endoplasmic reticulum oxidoreductin family. The encoded protein is localized to the endoplasmic reticulum and promotes the formation of disulfide bonds by oxidizing protein disulfide isomerase. This gene may play a role in endoplasmic reticulum stress-induced apoptosis and the cellular response to hypoxia.