Lyrica Side Effects: Is It Bad For You?

Short and long-term symptoms you shouldn’t ignore if you’ve taken Lyrica recently

Written by: Enjuris Editors

Lyrica is a popular anticonvulsant used to treat neuropathic pain, fibromyalgia, post-herpetic peripheral neuropathy, and other conditions. It has also been known to cause serious and long-term side effects. Read on to see if your symptoms merit a visit to your doctor’s office or a law firm.

Lyrica, the brand name for pregabalin, is an antiepileptic drug (also known as “anticonvulsant”) intended to help treat peripheral neuropathy caused by diabetes or other types of nerve pain like shingles, spinal cord injury, nerve pain, postherpetic neuralgia, partial onset seizures in epileptic adults, and fibromyalgia.

Why is Lyrica prescribed for so many conditions?

Gabapentinoids, the class of medication to which Lyrica belongs, are increasingly being prescribed for conditions that they’re not approved to treat. This is thought to be a reflex to the growing opioid epidemic; doctors avoid prescribing opioids by offering gabapentinoids, instead. Lyrica and other gabapentinoids are offered as a first-line treatment when lesser interventions don’t work.

Enjuris tip: If your doctor recommends a gabapentinoid regimen, make sure to do your research and find out if the pros outweigh the cons.

Sadly, this doesn’t reduce the potential for abuse, as discovered in random urine tests.

One in five patients found to be taking Gabapentin, a similar medication to Lyrica, were doing so without a prescription. Pfizer, which manufactures both Neurontin (the brand name for gabapentin) and Lyrica, has paid billions of dollars in fines to the FDA for illegal marketing activities. According to the U.S. Justice Department, a case over four Pfizer drugs for illegal marketing led to the biggest fine in American history‚ for any legal matter, not just drug violations. In the end, the pharmaceutical giant was forced to pay $2.3 billion.

Using Lyrica without a prescription can lead to psychedelic highs. The U.S. Drug Enforcement Agency classifies it as Schedule V, so it’s easier to obtain a prescription because it’s considered to have a lower potential for abuse. It operates on both the gamma-aminobutyric acid (GABA) and dopaminergic reward systems in the body, which can create euphoria, sedation, marijuana-like highs, and dissociative effects.

Physicians have lowered their thresholds for prescribing drugs like these because more patients are experiencing non-cancer pain that would otherwise be treated with opioids. In today’s medical climate, doctors are wary of prescribing too many opioids, which has led to an increase in gabapentinoid prescriptions. There are few other options, and when NSAIDs or acetaminophen don’t achieve the desired results, gabapentinoids are typically the next step.

Marketing practices don’t help this situation either, as manufacturers conduct massive campaigns to reach the ears and eyes of patients and their doctors. As of 2016, pregabalin was the 10th most prescribed medication in the United States, which translated to 64 million prescriptions. That was an increase of 39 million from 2012.

How many off-label uses does Lyrica have? Way too many, according to researchers.Tweet this

Some physicians are concerned with this development for the following reasons:

While scientific evidence supports the efficacy of some drugs for off-label uses, this hasn’t been the case for gabapentinoids. Researchers found that clinical studies of gabapentinoids for pain control only examined the mitigation of postoperative pain, which isn’t pain that the general population experiences. Lyrica is most often prescribed for common, everyday pain, which hasn’t been fully studied. For instance, a placebo-controlled trial showed that pregabalin was ineffective for sciatica patients. There were also limited evidence in studies of its efficacy for chronic low back pain.

Pregabalin has nontrivial side effects, such as dizziness and sedation. Up to 40% of patients taking this drug reported dizziness, compared to 13% on a placebo regimen. Since gabapentinoids are often prescribed with other medications that affect the central nervous system, these side effects can be intensified.

Patients misuse and abuse pregabalin and gabapentin. Withdrawal often occurs after doses are stopped.

Indiscriminate off-label use reinforces the viewing of pain as something that can be solved by medication when patients should focus on other interventions.

Since gabapentinoids are touted as the “safer” alternative to opioids, this trend is likely to continue. Additionally, the American Pain Society recommended that gabapentin be considered for post-operative pain relief, which doesn’t help the majority of patients. This was endorsed by the American Society for Regional Anaesthesia.

What to do if you think Lyrica is causing side effects

If you’ve been affected by Lyrica and are suffering side effects, you should first speak to your doctor. Then, talk to an attorney who handles bad drug lawsuits. He or she can advise you as to possible courses of legal action and determine whether you can recover damages.

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