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Decreased cerebral perfusion and increased cerebral white matter changes have been found in the elderly.These age-related cerebral hypoperfusion would result in dementia, gait disturbance, and disables. However, itspathophysiologies have not elucidated yet. The internal jugular venous hemodynamic profiles in ourultrasonographic registry suggest an increase in internal jugular venous outflow impedance with aging. Weproposed the hypothesis that jugular venous reflux plays a role in age-related white matter changes. In thepresent talk, I will provide data suggesting that retrogradely-transmitted venous pressure of jugular venousreflux could reach cerebral venous system and influent cerebral blood flow in our clinical Dopplerultrasonographic studies. The results of studying the relationship between jugular venous reflux and agerelatedwhite matter changes will also be demonstrated. At last, I will talk about some preliminary data aboutour animal model of jugular venous reflux.

Dr. Chung has an animal model of jugular venous reflux? I am assuming it is the 'Doepp' version of reflux, when the valve is insufficient and does not fully close after the flow passes, letting flow back in to the jugular.

There is reflux animal research being done on marmosets, but there was nothing about that mentioned at isnvd, as far as I know.

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