Speed up and simplify online sample clean-up, high performance chromatographic separation and mass spectrometric analysis of complex samples with the Thermo Scientific Prelude SPLC Sample Preparation and Liquid Chromatography System. The Prelude SPLC system has two separate LC channels that can be operated in parallel or serial modes and channeled serially into a single mass spectrometer, such as the Thermo Scientific TSQ Triple Quadrupole Endura.