Compare the frequencies of the diagnoses of clinically significant lesions [ Time Frame: at the end of video-capsule exploration ] [ Designated as safety issue: No ]

Compare the frequencies of the diagnoses of clinically significant lesions (P1 or P2)obtained with and without polyethylene glycol preparation for patients investigated by video-capsule endoscopy who have an unexplained digestive bleeding.

Compare the frequencies of the diagnoses of clinically significant lesions (P1 or P2)obtained with and without polyethylene glycol preparation for patients investigated by video capsule endoscopy (VCE) who have an unexplained digestive bleeding.

Compare gastric emptying time, the bowel transit time and the percentage complete medical exploration of small bowel for every group of patients (ileo caecal valve exceeded).

Current Other Outcome Measures ICMJE

Not Provided

Original Other Outcome Measures ICMJE

Not Provided

Descriptive Information

Brief Title ICMJE

Efficacy of Small Bowel Preparation in Capsule Endoscopy

Official Title ICMJE

Impact of Small Bowel Preparation Using Polyethylene Glycol for Endoscopic Video-capsule (EVC)Exploration in Unexplained Gastrointestinal Bleedings

Brief Summary

The best preparation of small bowel is still unknown. The primary aim of this study is to evaluate the polyethylene glycol (PEG) impact of small bowel preparation for unexplained gastrointestinal bleeding exploration. Three different preparations are evaluated in this study.

Detailed Description

Now days, the endoscopic video-capsule is the more appropriate exam for unexplained gastrointestinal bleeding exploration. The responsible damage of this unexplained bleeding are frequently small vascular damages, hard to be detected in the bowel or ulcerations or tumors. The exam quality can be limited by food residues, bubbles or bile.

30% of damage are probably undetectable because of a lack of visibility. An efficient preparation will probably increased the quality of the video-capsule exploration.

The bowel exploration by endoscopy video-capsule will be realized in the usual condition. The study included 4 steps:

Inclusion

Randomization

Video-capsule exploration

Reading of the video-capsule exam by endoscopist doctors who are in blind.

apply the standard diet and drink 2 liters of polyethylene glycol between 19h and 21h the day before exploration. Then drink 500 ml of polyethylene glycol 30 minutes after the endoscopy video-capsule ingestion.

Study Arm (s)

Placebo Comparator: Preparation 1

Standard diet: the day before video-capsule exploration : Drink only clears liquids after the lunch, fasting from 22 hours except usual drugs with a mouthful water.

Intervention: Drug: Standard diet

Active Comparator: Preparation 2

Standard diet : the day before video-capsule exploration : Drink only clears liquids after the lunch, fasting from 22 hours except usual drugs with a mouthful water.

500 ml of polyethylene glycol 30 minutes after the ingestion of video-capsule endoscopy.

Intervention: Drug: Standard Diet + 500 ml of polyethyleneglycol

Active Comparator: Preparation 3

Standard diet : the day before video-capsule exploration : Drink only clears liquids after the lunch, fasting from 22 hours except usual drugs with a mouthful water.

2 liters of polyethylene glycol between 7 pm and 9 pm.

500 ml of polyethylene glycol, 30 minutes after the ingestion of video-capsule endoscopy.