It is estimated that nearly half of our world population has what is known as the MTHFR gene mutation. Researchers and physicians alike are beginning to recognize the gene’s complexity and how that complexity is capable of impacting every facet of our health—as well as how we can use methylated vitamins to improve our health.

Listen to our methylation expert, Kendal Stewart, MD, on why methylation issues are so common and what you can do.

What are MTHFR mutations?

An MTHFR mutation refers to an anomalous variant of the gene methylenetetrahydrofolate reductase (shortened to MTHFR), which is responsible for production of a crucial enzyme of the same name. This enzyme acts as a catalyst to a bodily process known as methylation, the addition of a methyl group to a source substance, such as a toxin or unrefined nutrient, in order to produce a new chemical. Methylation, then, is a process which is imperative to proper function all throughout our bodies. It is involved in the production of neurotransmitters, generation of energy, regulation of hormones, transformation of nutrients, and detoxification. When a mutation in the MTHFR gene manifests itself, it results in less efficient methylation, which is suspected to be a potential root for an extensive list of health issues, both physical and mental.

How Can We Stimulate Methylation?

Specifically, MTHFR activates the folic acid we intake through our diet, converting it into a form usable by our cells (5-MTHF). That activated substance, methylfolate, then goes on to stimulate the process of methylation. Those affected by the MTHFR mutation are unable to process folic acid in a healthy manner, and as such, they are encouraged to incorporate supplements of active folate into their dietary habits. Stimulating methylation can alleviate a great number of stubborn, otherwise unexplained symptoms, such as lack of energy, mood issues, sleep pattern instability, among many other near-immune issues. Adding methylfolate supplements to a nutritional regimen may help. Call
866-500-5388 or view our podcasts section for more educational information from our experts and to learn more about our genetic mutation supplements.

L-5-MTHF (5-Methyltetrahydrofolate) is the most common biologically active form of the water soluble B vitamin, folate. Folate must be converted to its active forms to be used by the body. This is a multi-step biochemical process that occurs in the intestines and liver. In the presence of intestinal or liver dysfunction this conversion may not occur sufficiently enough to meet the body's needs.

Folate deficiencies are common as many individuals do not consume enough folate-rich foods and dietary folates are readily destroyed by cooking or processing. Although typically included in multivitamins, some individuals do not effectively methylate and convert folic acid, the form of folate commonly found in fortified foods and supplements, into its active form thus are still at risk of deficiency. Metafolin® L-5-MTHF, an active, methylated form of folate, requires no additional metabolic steps to be used by the body, thus it is often the preferred choice for those with absorption or metabolic defects. L-MethylFolate efficiently supports methylation, DNA biosynthesis, homocysteine metabolism, and nervous system function. Supplies 1 mg (1,000 mcg) folate per capsule.

It is estimated that up to 60-percent of the U.S. population may have a genetic enzyme defect that makes it difficult for them to convert folic acid into active 5-MTHF. For these individuals and many others, 5-MTHF supplementation may be a more effective method of folate repletion.

Methylation Support - Step One

Supreme bioactive fast-dissolving tablets.

For those who may be sensitive to supplementation but are looking for methylation support, this is considered Methylation Support: STEP 1. Once this is tolerated well then you may consider moving to Methylation Support: STEP 2 with our Methylation Complete Fast Dissolves.

Methylation Support - Step One® combines the active coenzyme form of vitamin B12, methylcobalamin, with an active form of folate, Metafolin®* L-5-methyltetrahydrofolate. This bioactive formula was created to bypass normal absorptive mechanisms for vitamin B12 and folate which may be lacking due to aging, diet, or gastrointestinal issues.

Fast-dissolving tablets allow for quick release into the bloodstream. Vitamin B12 and folate play an integral role in DNA synthesis and thus are essential to cell division and proper functioning of virtually all tissues in the body.

Vitamin B12 and folate also participate in methylation and proper metabolism of homocysteine, a potentially toxic metabolite of methionine. Dietary B12 can be reliably obtained only from animal products and is a singularly difficult vitamin to absorb. Active B12-Folate may be especially beneficial for vegetarians and persons with impaired stomach absorption issues.

For those who may be sensitive to supplementation but are looking for methylation support, this may be considered Methylation Support: STEP 1. Once this is tolerated well then you may consider moving to Methylation Support: STEP 2 with our Methylation Complete Fast Dissolves.

BioActive B12 Folate® combines the active coenzyme form of vitamin B12, methylcobalamin, with an active form of folate, Metafolin®* L-5-methyltetrahydrofolate. This bioactive formula was created to bypass normal absorptive mechanisms for vitamin B12 and folate which may be lacking due to aging, diet, or gastrointestinal issues.

Fast-dissolving tablets allow for quick release into the bloodstream. Vitamin B12 and folate play an integral role in DNA synthesis and are essential to cell division and proper functioning of virtually all tissues in the body.

Vitamin B12 and folate also participate in methylation and proper metabolism of homocysteine, a potentially toxic metabolite of methionine. Dietary B12 can be reliably obtained only from animal products and is a singularly difficult vitamin to absorb. Active B12-Folate may be especially beneficial for vegetarians and persons with impaired stomach absorption issues.

Optimal Methylation Support Formula Recommended for Neurological, Psychological and Nervous System Disorders.Methyl Excel™ features five key nutrients involved in homocysteine metabolism. Provided in therapeutic levels and activated forms, Methyl Xcel supports enhanced methylation of vitamins to the nervous system.

These fast-dissolving tablets contain a high concentration of vitamin B12 to bypass normal absorptive mechanisms that rely on intrinsic factor. Studies show that B12 can be absorbed by passive diffusion across intestinal membranes when intake is greatly increased. Methyl-B12 Lozenge is a good choice for those with difficulty absorbing vitamin B12.

Tablets may be dissolved in the mouth or swallowed whole. Scored tablets contain natural cherry flavor and xylitol and mannitol as natural sweetening agents.

Why is Vitamin B12 necessary?

Knowing the facts about vitamin B12 is vital to your health. This essential micronutrient affects the development and maintenance of red blood cells, nerve cells, and normal myelination (covering) of nerve cells. It also aids in the production of DNA and RNA and the production of neurotransmitters.

What CogniQ includes?

Pyrroloquinoline Quinone 20 mg (PQQ)

Co-Enzyme Q-10 – 300 mg

As the primary engines of almost all bioenergy production, the mitochondria rank among the structures most vulnerable to destruction from oxidative stress and damage. PQQ’s formidable free radical–scavenging capacity helps the mitochondria with superior antioxidant protection along with other cognitive support.*

As a bioactive coenzyme, PQQ actively participates in the energy transfer within the mitochondria that supplies the body with most of its bioenergy (like CoQ10).

Pyrroloquinoline Quinone and Co- Enzyme Q-10 are the two major ingredients which form this powerful supplement. The combination of these ingredients is developed to support memory recall , mitochondrial energy and to show positive results. CogniQ has antioxidant properties that may protect oxidation of cells.*

What may be its benefits?

100% natural ingredients

Increase memory and focus*

Increase memory functions*

Provide nutrients to brain needed for optimal function*

Increase cognitive health*

Provide the necessary energy to mitochondria*

Increase energy and clean mental view*

NEW Exclusive formula created by leading Neurotologist, Kendal Stewart, MD, that is safe and effective for people of all ages. This product was designed and may assist with:

Full Focus+™ consists of 10 ingredients carefully formulated by our advising physicians to work together to maximize each ingredients's full potential and improve vitamin delivery. This processing support formula consists of very integrated ingredients such as Green Coffee Bean extract, SAMe, L-Taurine, L-Methionine and other important ingredients for improved brain performance, mood and memory.

Our unique delivery system assures that our pharmaceutical grade Methylation Complete™ promotes and enhances the methylation processes needed to improve the production of glutathione, and allow maximum B12, B6 and 5-MTHF (bioactive and methylated form of folate) delivery to the nervous and immune systems.

Fast-dissolving tablets allow for quick release into the bloodstream. Vitamin B12 and folate play an integral role in DNA synthesis and thus are essential to cell division and proper functioning of virtually all tissues in the body. Active B12 and Folate may be especially beneficial for persons who are vegetarian or with impaired gastrointestinal absorption due to aging, illness, surgery or a methylation deficiency.This fast dissolving tablet may help maximize and aid in:

Mood Improvement & Stabilization

Mental Focus & Concentration

Organization Skills

MTHFR / MTRR Mutations

Short Term Memory

Sleep Patterns

Immune Health

Topical Cream for Methylation, Neurological, Nervous & Immune System Support

As a solution, our unique topical delivery system, assures that our pharmaceutical grade Neuro-Immune Stabilizer Cream promotes and enhances the methylation processes needed to improve the production of glutathione, increase Vitamin D levels and allow maximum B12, B6 and vitamin delivery to the nervous and immune systems. This potent nutrient-rich cream may help maximize and aid in:

Mood Improvement & Stabilization

Mental Focus & Concentration

Organization Skills

MTHFR mutations

Short Term Memory

Cerebral Folate Deficiency

Hormonal Regulation

Support a health sleep cycle

Immune Function

Such nutrients as Pyridoxal 5-Phosphate (B6) and Vitamin B12 in a methylated form called methylcobalamin (Methyl B12) and hydroxycobalamin (Hydroxy B12) and natural Vitamin D assist the body neurologically and physically.

It is estimated that roughly one in three Americans have genetically inefficient enzymes that help create 5-MTHF (folinic acid) so this cream will assist with supplying the 5-MTHF for optimal help.

The addition of Vitamin K in this methylation suppport cream is recommended for those who are hindered by a methylation deficiency and/or a VDR Taq genetic polymorphism which inhibits the person's ability to absorb vitamin D at the cellular level without the cofactor Vitamin K. Impaired vitamin D function due to this polymorphism can result in significant immune weakness, early bone loss and increased risk of cognitive decline and mood issues.*

As a solution, our unique topical delivery system, assures that our pharmaceutical grade Methylation Pro promotes and enhances the methylation processes needed to improve the production of glutathione, increase Vitamin D levels and allow maximum B12, B6 and vitamin delivery to the nervous and immune systems. This potent nutrient-rich cream may help maximize and aid in:

Mood Improvement & Stabilization

Mental Focus & Concentration

Organization Skills

MTHFR Mutations

Short Term Memory Loss

Supporting a healthy sleep cycle

Immune Function and well-being

Such nutrients as Pyridoxal 5-Phosphate (B6) and Vitamin B12 in a methylated form called methylcobalamin (Methyl B12) and hydroxycobalamin (Hydroxy B12), natural Vitamin D and K assist the body neurologically and physically.

Created by Dr. Kendal Stewart, M.D., this kit combines all the necessary supplements to improve your sensory system, boost your immune system and diminish the issues and negative effects on the body and mind that may be caused by Neuro-Immune Syndromes and methylation issues.

This kit includes our powerful Methylation Pro Topical Cream that not only improves immune function, but will also enhance mental focus and concentration. The kit features our Mito Cell PQQFormula designed to restore proper mitochondrial function as well. In addition, we have also incorporated our Full Focus+ supplement to aid in dopamine level support. Last, but certainly not least, the kit includes our exclusive Neuro-Immune Infection Control formula to combat the activation and overgrowth of yeast, bacteria and other viral agents that can negatively affect a patientÕs health, healing, well-being and cognitive functions. This powerful combination may be used by adults and children of all ages.