Browse Databases and Tools

About this Resource

The Cochrane Database of Systematic Reviews is considered the gold standard for
evidence-based medicine. Essential Evidence Plus includes the latest and most
up-to-date summaries of systematic reviews from the Cochrane Library, which are
the most rigorous and reliable evaluations of medical therapies available. You’ll
find summarized evaluations of the world’s best literature on the effectiveness of
therapy for 3,300+ clinical problems.

Operative caries management in adults and childrenCochrane Systematic Reviews, 25-Feb-2013The management of dental caries has traditionally involved removal of all soft demineralised dentine before a filling is placed. However, the benefits of complete caries removal have been questioned because of concerns about the possible adverse effects o

Operative procedures for fissure in anoCochrane Systematic Reviews, 28-Sep-2011Reports of direct comparisons between operative techniques for anal fissure are variable in their results. These reports are either subject to selection bias (in non-randomized studies) or observer bias (in all studies) or have inadequate numbers of patie

Operative versus conservative management for 'fetal distress' in labourCochrane Systematic Reviews, 9-May-2012Suspected fetal distress usually results in expedited delivery of a baby (often operatively). The potential harm to a mother and baby from operative delivery may not always be justified especially when fetal distress may be misdiagnosed. Even with a corre

Opioid agonist treatment for pharmaceutical opioid dependent peopleCochrane Systematic Reviews, 4-May-2016There are increasing concerns regarding pharmaceutical opioid harms including overdose and dependence, with an associated increase in treatment demand. People dependent on pharmaceutical opioids appear to differ in important ways from people who use heroi

Opioid antagonists for alcohol dependenceCochrane Systematic Reviews, 17-Oct-2010Alcohol dependence belongs to the globally leading health risk factors. Therapeutic success of psychosocial programs for relapse prevention is moderate and could be increased by an adjuvant treatment with the opioid antagonists naltrexone and nalmefene.

Opioid antagonists for smoking cessationCochrane Systematic Reviews, 23-May-2013The reinforcing properties of nicotine may be mediated through release of various neurotransmitters both centrally and systemically. People who smoke report positive effects such as pleasure, arousal, and relaxation as well as relief of negative affect, t

Opioids compared to placebo or other treatments for chronic low-back painCochrane Systematic Reviews, 21-Aug-2013The use of opioids in the long-term management of chronic low-back pain (CLBP) has increased dramatically. Despite this trend, the benefits and risks of these medications remain unclear. This review is an update of a Cochrane review first published in 200

Opioids for acute pancreatitis painCochrane Systematic Reviews, 25-Jul-2013Acute pancreatitis is an acute inflammatory process of the pancreas that may also involve adjacent tissues and/or remote organ systems. Abdominal pain is the main symptom and is usually accompanied by nausea, vomiting and fever. Opoids are commonly used t

Opioids for agitation in dementiaCochrane Systematic Reviews, 7-May-2015Agitation is a common experience for people living with dementia, particularly as day-to-day function and cognition start to decline more. At the present time there are limited pharmacological options for relieving agitation and little is known about the

Opioids for cancer pain - an overview of Cochrane reviewsCochrane Systematic Reviews, 7-Jul-2017Pain is a common symptom with cancer, and 30% to 50% of all people with cancer will experience moderate to severe pain that can have a major negative impact on their quality of life. Opioid (morphine-like) drugs are commonly used to treat moderate or seve

Opioids for cancer-related pain in children and adolescentsCochrane Systematic Reviews, 14-Aug-2017Pain is a common feature of childhood and adolescence around the world, and for many young people, that pain is chronic. The World Health Organization (WHO) guidelines for pharmacological treatments for children's persisting pain acknowledge that pain in

Opioids for chronic non-cancer pain in children and adolescentsCochrane Systematic Reviews, 14-Aug-2017Pain is a common feature of childhood and adolescence around the world, and for many young people, that pain is chronic. The World Health Organization guidelines for pharmacological treatments for children's persisting pain acknowledge that pain in childr