INFLUENCE OF EARLY APPLICATION OF TRIMETAZIDINE ON TUMOR NECROSIS FACTOR ALPHA CONCENTRATION IN BLOOD SERUM OF RATS WITH DIFFERENT RESISTANCE TO HYPOXIA AT MODELLING OF DIFFUSE CARDIOSCLEROSISSaturska H.S.

UDC: 616.12-004-097-02:616.152.21]-085.27-092.9

Abstract: The article presents the results of an experimental study of changes of tumor necrosis factor alpha (TNFα) concentration in blood serum at the development of diffuse cardiosclerosis (DCS) in rats with different resistance to hypoxia at early application of trimetazidine. Experiments were done on 192 experimental white male rats which were divided into groups according to their different resistance to exogenous hypobaric hypoxia. Experiments proved that early correction of DCS with 10 mg/kg trimetazidine, when administered per os to rats daily from the first day of disease, has an inhibitory effect on the content of TNFα in blood serum of animals. TNFα concentration in the blood serum of animals is significantly increased after 7 days of modelling of DCS and trimetazidine correction followed by a reduction in the activity of inflammatory changes. Normalization of TNFα concentration in serum of animals with higher resistance to hypoxia at 30-day stage of observation of DCS against the trimetazidine background indicates less intense inflammatory changes in this group of animals. Given the impact of the drug on intensity of inflammatory changes in the pathogenesis of the studied pathology, the research extends the substantiation of therapeutic use of agents stimulating endogenous cardioprotection. The features discovered were analyzed using the latest scientific achievements in the field.

Abstract: This paper is a review on modern scientific investigations concerning the role of reactive oxygen species (ROS) in cellular physiology and pathophysiology. Key issues of ROS generation, their function in signaling pathways and role in cellular pathology as well as functioning of the antioxidant system are discussed in the paper. The paper also summarizes literature data on potentials of pharmacological regulation of the activity of free radical oxidation reactions having practical significance for efficient pharmacotherapy of diseases involving destructive action of reactive oxygen species.

GENDER AND AGE ASPECTS OF THE PREVALENCE OF DRUG ABUSE IN THE REPUBLIC OF BELARUSLelevich V.V., Vinitskaya A.G., Lelevich S.V., Tishchenko Ye.M., Konorazov I.I.

UDC: 613.81/.84(486)

Abstract: Gender and age differences in incidences of drug abuse have been investigated on the basis of official data of the Narcological Service of the Ministry of Health of the Republic of Belarus. The study involved patients with addictions syndrome to narcotic drugs and nonnarcotic psychoactive substances, registered in drug abuse reports of the Ministry of Health. Analysis of patients abused to psychoactive substances was performed on the basis of social and epidemiologic parameters given in registration charts of firstly diagnosed patients and taken off the National Narcological Register. Dependence on certain drugs (opioids, cannabinoides, inhalants, tranquillizers, and sedatives) was been shown to correlate with gender and age of registered drug abusers. The data obtained confirm the necessity of gender and age-related studies on drug abuse prevalence. They can be of practical use for development of preventive activities to combat the spread of drug addiction.

Abstract: Role of interferons in allergic diseases is complex and not clear enough. The aim of the study was to evaluate a-interferon production in patients with pollinosis during certain periods of the disease and following various types of therapy. A total of 75 patients with pollinosis and 45 healthy controls were enrolled in the study. We assessed the level of α-interferon production by activated leukocytes in vitro. Interferon level was measured with the cytopatic effect reduction assay. Interferon induction was performed in whole blood cells with Newcastle virus for 24 hours at 37 C with 5% CO Interferon level in supernatant was measured with the cytopathic effect reduction assay using encephalomyocarditis virus and human M19 fibroblast cells cultured in Eagle medium with 10% fetal bovine serum (10 cell/ml). We concluded that there can be a-interferon deficiency in patients with pollinosis. In allergen specific immunotherapy there was a significant stable increase in α-interferon production. We have not identified any significant change in α-interferon production following any medical therapy. Suppression of α-interferon production by leucocytes in vitro confirms inhibitory effect of IgE onto interferon synthesis.

STANDARDIZATION OF QUALITY EVALUATION OF DOPPLER ULTRASONOGRAPHY OF THE KIDNEYS IN CHILDREN WITH OBESITY AND METABOLIC SYNDROMEBorsukov A.V., Bekezin V.V., Kozlova E.U.

UDC: 616-072.7

Abstract: Diagnostic value of qualitative assessment of renal blood flow intensity with a standardized procedure in adolescents with obesity and metabolic syndrome is discussed in the paper. The study involved 41 patients investigated with a Doppler ultrasound technique. Ultrasonography was performed with a digital portable ultrasound system ANGIODIN-Sono/P-Ultra ("BIOSS", Russian). Children with obesity and metabolic syndrome have been found to have high frequency of registration 2, 3, and 4 types of renal blood flow, witnessing the decline in its intensity. Power Doppler technique with a standardized evaluation scheme is able to determine the intensity of renal blood flow in children with obesity and metabolic syndrome rather accurately due to the high reproducibility of the technique.

Abstract: Modern pharmaceutical market requires certain changes in traditional understanding of human resources management. The number of the social and psychological studies devoted to the problems affecting various aspects of pharmaceutical specialists work has increased. Results of the studies are actively implemented into practice of pharmaceutical companies. Professionally significant features representing a set of personal qualities contributing to professional success are analyzed. Pharmaceutical business is sure to require specific qualities of a personality: motivation for communication, working capacity, patience and attentiveness in a high level of psychological readiness. Interpersonal relations of the staff have a significant influence on efficiency of teem-work. Taking social and psychological features into account allows improving the efficiency of the pharmaceutical business. Study of psychological characteristics of four small groups, the technique of diagnostics of the interpersonal relations is presented in the paper. The study involved Timothy Leary's test. It demonstrated an opportunity to use successfully the technique in staff management in pharmaceutical business.

Abstract: The article describes a clinical case of a patient with undifferentiated connective tissue disease. The disease had a great variety of clinical manifestation, so diagnostics was a challenge for doctors of different specialties, both at outpatient and inpatient departments. Analysis of differential diagnostics has been carried to exclude pneumonia, extrinsic allergic alveolitis, infectious diseases, coronary heart disease, hypothyroidism, dissecting aortic aneurysm, myocarditis, pericarditis, severe sepsis, mixed and undifferentiated connective tissue disease.

Abstract: This article is devoted to potentials of immunoprophylaxis of infectious diseases which is considered to be a topical field of practical immunology. This review is on recent advances in the development of new generation vaccines. New approaches to development of prophylactic agents and their advantages in comparison with traditional drugs are analyzed in the paper. New and promising generation of vaccines is characterized in detail and examples of developed vaccine are also given. The mechanisms of action of post-vaccination immunity and factors influencing its formation are described.

TREATMENT OF CHRONIC WOUNDSPleshkov V.G., Privolnev V.V., Golub A.V.

UDC: 616.91-003.9

Abstract: The article discusses in detail factors leading to formation of chronic wounds, as well as diagnostic criteria and algorithms of evaluation of chronic wounds. We have analyzed existing approaches to the treatment of chronic wounds and given certain recommendations on surgical treatment, application of local antimicrobial agents and subsidiary aids in the treatment of chronic wounds. The article describes the most common errors in curative tactics in chronic wounds.

CONCEPTUAL APPROACH TO ORGANIZATION OF PRACTICAL TRAINING IN THE SYSTEM OF HIGHER SCHOOLSKonyshko N.A., Matuskov M.A.

UDC: 614.23

Abstract: Experts’ opinions on organization of practical training of future medical doctors are given in the paper. The study performed confirms that this sector of health service is characterized by a number of stages with a high degree of regulation and control, close integration and clear hierarchical levels. Effectiveness of the strategy to organize and control the students’ practical training is due to both professional and personal qualities of consumers and providers in the educational sector and paternalistic position of the Heads in combination with a focus on rational organization of management.

IN COMMEMORATION OF PROF. L.S.STRACHOUNSKYKozlov S.N.

Abstract: Experts’ opinions on organization of practical training of future medical doctors are given in the paper. The study performed confirms that this sector of health service is characterized by a number of stages with a high degree of regulation and control, close integration and clear hierarchical levels. Effectiveness of the strategy to organize and control the students’ practical training is due to both professional and personal qualities of consumers and providers in the educational sector and paternalistic position of the Heads in combination with a focus on rational organization of management.

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