1836 – The Covington-Lexington Turnpike was completed and Florence became the first stagecoach stop south of Covington.

1851 – Town Hall, also used as a school, was erected on a site on Main Street (the site is now occupied by an attorney's office).

1855 – The first agricultural fair in the county was held in Florence. Closed 1881 on J. Barton land near present day Kentaboo road.

1862 – An advance guard of the Confederate Army under the command of Brig. Gen. Henry Heath, whose main force had camped at Corinth and Snow's Pond near Walton, encountered Union pickets in the area around the Christian Church. One man was killed, 18 wounded and the Yankees were routed by veteran Confederate troops who were part of a unit known as “Morgan's Raiders.”

1869 – International Order of Odd Fellows built a lodge hall on Main Street. The first floor was leased to various commercial entities over the years.

1872 – Greenwood Lake (Erlanger) got a railroad station and took some of the traffic from Florence.

1896 – Northern Agricultural Fair Association was organized to hold a four-day fair every fall in Florence. The area bounded by U.S. 42, U.S. 25, Gibbons Street and Fair Street was known as the old Fairgrounds.