Variation in susceptibility to infectious disease often has a substantial genetic component in animal and plant populations. We have used genome-wide association studies (GWAS) in Drosophila melanogaster to identify the genetic basis of variation in susceptibility to viral infection. We found that there is substantially more genetic variation in… (More)

To understand the molecular basis of how hosts evolve resistance to their parasites, we have investigated the genes that cause variation in the susceptibility of Drosophila melanogaster to viral infection. Using a host-specific pathogen of D. melanogaster called the sigma virus (Rhabdoviridae), we mapped a major-effect polymorphism to a region containing… (More)

The authors would like to correct four errors in the manuscript: 1. In Fig 5C, the relative viral titre bars are at the wrong height. In the figure, the Ge-1(S) ctrl (grey bar) and Ge-1(H) ctrl (grey bar) have higher relative viral titre than Ge-1(S) DCP1 KD (red bar) and Ge-1(H) DCP1 KD (blue bar). However, the DCP1 KD should have higher viral titres than… (More)

Hosts encounter an ever-changing array of pathogens, so there is continual selection for novel ways to resist infection. A powerful way to understand how hosts evolve resistance is to identify the genes that cause variation in susceptibility to infection. Using high-resolution genetic mapping we have identified a naturally occurring polymorphism in a gene… (More)