ab172730 - Rabbit monoclonal IgG, is suitable for use as an isotype control with this antibody.

IHC-P

1/250 - 1/500.

追加情報Is unsuitable for ICC or IP.

ターゲット情報

機能Plays a role in the translocation of transport vesicles from the cytoplasm to the plasma membrane. Inhibits the translocation of SLC2A4 from intracellular vesicles to the plasma membrane by STX4A binding and preventing the interaction between STX4A and VAMP2. Stimulation with insulin disrupts the interaction with STX4A, leading to increased levels of SLC2A4 at the plasma membrane. May also play a role in the regulation of insulin release by pancreatic beta cells after stimulation by glucose.

配列類似性Contains 1 PDZ (DHR) domain.Contains 1 WW domain.

翻訳後修飾Phosphorylated on Ser-99 by PKB/AKT2 after insulin treatment. Phosphorylation on Ser-99 abolishes the interaction with STX4A (By similarity). Phosphorylated upon DNA damage, probably by ATM or ATR.