Make sure the system volume on your computer is turned up and not muted at all.

In DesktopChat SE, click on Edit and make sure Speech Off is unchecked.

Click on Edit->General Settings and then click on the Microsoft SAPI tab. Make sure the volume slider is set to Loud and the Pitch is set midway. Note: For Windows Vista and Windows 7 installations, the only voice that will speak in DesktopChat SE is Microsoft Anna.

If LH Michael or LH Michelle are available for a voice do not select them because DesktopChat SE will crash after a few clicks.