Academic Course List

ClassID

Name

Description

Credits

PHRM 1000

Human Anatomy Physiology

This course is an integrated, in-depth study of the anatomy and physiology of the human body, including cells, tissues, integument, skeletal, muscular, and nervous systems and sense organs. There is also emphasis on cardiovascular, lymphatic, respiratory, digestive, endocrine, excretory, and reproductive systems and human development. Prerequisite BIOL 1101 General Biology I

3

PHRM 4100

Immunology Virology

This course is an introduction to Immunology and Virology. Topics will include the basic concepts of immunity, including molecular and cellular composition of the immune system and immune processes that are responsible for defense against pathogens and tumors, as well as allergic and autoimmune reactions. Structure and function of viruses, viral diseases, vaccines, cancer, immunological techniques used in industry, use of viruses in the biotechnology industry will all be included within this course. The course will also include theoretical discussion of therapeutic and diagnostic uses of antibodies, sterile technique, hybridoma production, selection and cell cloning. Prerequisite BIOL 3330 Molecular Cell Biology, or with the consent of the instructor

3

PHRM 4110

Bioprocess Cell Culture

This course teaches the skills needed to work as a scientist in biotechnology production. Students will grow and monitor bacterial and mammalian cells on a laboratory scale that emulates the large scale production used in industry. Students will become familiar with the cleaning, sterilization, aseptic inoculation, operation and monitoring of fermenters and bioreactors. Students then recover and purify proteins produced by those cell cultures. They recover and purify proteins using centrifugation, ultrafiltration and chromatography techniques. The course emphasizes the use of current Good Manufacturing Practices (cGMP), and students gain experience following Standard Operating Procedures (SOP).Prerequisite BIOL 3330 Molecular Cell Biology, or with the consent of the instructor

3

PHRM 4111

Bioprocess Cell Culture Lab

This course teaches the skills needed to work as a scientist in biotechnology production. Students will grow and monitor bacterial and mammalian cells on a laboratory scale that emulates the large scale production used in industry. Students will become familiar with the cleaning, sterilization, aseptic inoculation, operation and monitoring of fermenters and bioreactors. Students then recover and purify proteins produced by those cell cultures. They recover and purify proteins using centrifugation, ultrafiltration and chromatography techniques. The course emphasizes the use of current Good Manufacturing Practices (cGMP), and students gain experience following Standard Operating Procedures (SOP).Prerequisite BIOL 3330 Molecular Cell Biology, or with the consent of the instructor

2

PHRM 4120

Assay Design

This course teaches the skills needed for employment in a research and development entity in the pharmaceutical and biotechnology industries. There will be an overview of the drug discovery process followed by detailed review of assay methods applicable to early phase small molecule discovery and upstream biologics development. Students will become familiar with different assays employed in the industries as screening tools and learn how to choose relevant assays to determine desired endpoints. Detailed review of protocols to enable, develop, and validate robust assays for target screening, potency and efficacy determinations, selectivity and specificity will be presented.Prerequisite CHEM 45004520 Biochemistry Lab, or with the consent of the instructor

4

PHRM 4130

Bioanalytical Chemistry

Interdisciplinary knowledge is becoming more and more important to the modern scientist. Bioanalytical chemistry is an interdisciplinary field in which analytical methods and instruments are used to solve problems of interest in biology or biochemistry. The goal of this course is to educate students in analytical methodologies used to separate and characterize compounds resulting from biotechnology and pharmaceutical companies. This course will provide students the opportunity to learn mass spectrometry of small molecules and biomolecules, LCMS, separation techniques (Gel filtration chromatography, High performance liquid chromatography (HPLC), spectroscopic techniques UVvis adsorption, luminescence and fluorescence and Capillary Electrophoresis (CE) and biosensor technology.Prerequisites CHEM 2020 Quantitative Analysis, CHEM 45004520 Biochemistry and lab, or with the consent of the instructor

3

PHRM 4131

Bioanalytical Chemistry Lab

Interdisciplinary knowledge is becoming more and more important to the modern scientist. Bioanalytical chemistry is an interdisciplinary field in which analytical methods and instruments are used to solve problems of interest in biology or biochemistry. The goal of this course is to educate students in analytical methodologies used to separate and characterize compounds resulting from biotechnology and pharmaceutical companies. This course will provide students the opportunity to learn mass spectrometry of small molecules and biomolecules, LCMS, separation techniques (Gel filtration chromatography, High performance liquid chromatography (HPLC), spectroscopic techniques UVvis adsorption, luminescence and fluorescence and Capillary Electrophoresis (CE) and biosensor technology.Prerequisites CHEM 2020 Quantitative Analysis, CHEM 45004520 Biochemistry and lab, or with the consent of the instructor

1

PHRM 5120

Advanced Biochemistry Lab

This course will expand on the basic concepts covered in CHEM4520. Students will deepen their knowledge of and handson experience with cloning, bacterial expression, enzyme purification and assay development. Students will perform a semesterlong project that involves amplification of a gene using PCR, cloning the PCR product, expressing the protein in E. coli, purifying the protein, and developing and optimizing an assay to measure enzyme activity. The purification will employ the AKTA System, a stateoftheart purification system from GE Healthcare that is specifically designed for protein purification. Handson practical experience will be gained in molecular biology, general biochemical techniques, and fundamental enzymology. Time 3 lab hours twice a week. Prerequisite CHEM 31203320 Organic Chemistry and lab, CHEM45004520 Biochemistry and Lab, or with the consent of the instructor