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SistemKB™ : Cumulative Knowledgebase of miRNA profiles

SistemKB™ is Sistemic’s in-house knowledge-base. It is a highly curated database of the biological functions and interactions of human microRNAs. Sistemic’s scientists gather information from the literature and in-house experiments to build a detailed picture of the biology of each microRNA. When a microRNA is then identified in a new experiment, its context can quickly be derived from SistemKB™. Alongside the curated biological information, SistemKB™ also houses the gene expression profiles of all microRNAs in all experiment performed by Sistemic.

This allows Sistemic scientists to quickly compare the expression of a microRNA in the current experiment to those previously found, offering additional, valuable contextual information. All Sistemic’s projects leverage the power of SistemKB™. The SistemKB™ knowledge-base is tightly integrated with Sistemic’s in-house literature mining tool, SistemSeek™

Recent News

Glasgow, United Kingdom; 28th January 2019: Sistemic Ltd. is pleased to announce that it has received Notification of Intention to Grant by the European Patent Office for the patent application entitled “Cell Characterisation” (European Patent Application No 11760806.7).

The patent covers the use of microRNA profiles for quality assessment of stem cells and derived cell therapy products.

Glasgow, United Kingdom; 22nd October 2018: Sistemic Ltd. is pleased to announce the completion of a Global Service and License Agreement for its SistemPSCCheck™ assay with Australian stem cell and regenerative medicine company, Cynata Therapeutics Ltd. The agreement will see the use of the SistemPSCCheck™ assay for the assessment of residual pluripotent stem cells in Cynata’s current iPSC-derived MSC clinical candidate CYP-001, as well other planned iPSC-derived MSC products.

We are looking for 2 life sciences graduates to support development of our new SistemPSCCheck™ v1.0 service product. These are 12 month placements, with the potential to develop into a permanent roles. For full information, please visit Scotgrad via the links below:

Sistemic will be attending the 4th Cell Therapy Conference: Manufacturing and Testing of Pluripotent Stem Cells in June to highlight the development of SistemPSCCheck™ - the world’s first commercial assay for assessment of pluripotent stem cell contamination in derived cell therapy products

GLASGOW, SCOTLAND Sistemic will be attending Phacilitate Cell & Gene Therapy World and the World Stem Cell Summit in January to highlight the development of their assay for assessment of pluripotent stem cell contamination in derived cell therapy products

Our Products

Sistemic’s platform technology pioneering the approach and development of miRNA-based profiling tools to guide and support Cell Therapy (CT) product development and drug discovery and repositioning

Allows for robust miRNA profiling, customised multi-layered statistical analysis, and biological interpretation and identification of the key markers (KmiR’s™) of cell phenotype. Whilst also seeking to maximise the utility and value of the KmiR’s™ identified

Sistemic's methodologies can also be applied to define, qualify and validating miRNA biomarkers from biofluids and surgical samples for prediction, diagnostic, prognostic, monitoring, toxicity and end-point.

Sistemic’s highly curated knowledge from internal and external projects covering miRNA and cell therapy-based knowledge. The database includes kmiR™ lists from all analyses and high impact meta-data. The knowledgebase is fully integrated with SistemSeek™ literature database