Turn printer on but LCD is not working at all. Plugging in additional EXT1 cable results in loud beeping sounds, for now I just completely disconnected this and hope to address this later.

Using the touch screen I can go to home and home X, Y axis although positions are wrong. The Y and X can move too far to end where there are no end stops resulting me having to turn printer off. It doesn’t know it’s original position. The end stop switches at other ends do work.

The Z axis motor plugged into the E1 is not moving.

When I go to other menu to simply ‘move’ axis this function is not working on any axis. I find this strange as the home x y and z do result in movement.

2208 drivers step *the opposite direction* of the 4988's you replaced. There are defines in configuration.h to tell Marlin to invert the axis, alternatively you can make your step rate negative for any axis you have 2208s on, some people even resort to re-arranging the pins in the connectors. Just uncommenting the 'invert_x_axis' or whatever define is the simplest way to deal with it IMHO.

Did you remove the MS3 jumpers when you installed the 2208 boards? I missed this step the first time I used this setup (MKS+2208), couldn't move the motors. Removing the jumper cleared that up.

I have no idea what screen comes with the 10s, but I have a 'reprap discount full graphics controller' that will only work with my MKS GEN L board if *both* cables are plugged in backwards. One appears to power the display, the other carries the encoder.