AFPplus Test (Triple Test)

What Is An AFP Test? (January 2019).

What is the AFP Test?

The AFP test (triple test) determines the risk of a chromosomal disorder, such as Down syndrome (trisomy 21). Unlike amniocentesis or chorion biopsy, this test can be performed without invasive surgery between the 14th and 17th week of gestation.

The AFP test only examines the mother's blood for alfafetoprotein, beta-HCG and estriol. From the values, the risk for the presence of trisomy 21 is then calculated, with a result of 1: 380 and higher than conspicuous.

How does the AFP test work?

In the AFPplus test, your blood is tested between the 14th and 17th week of gestation, usually at the 16th week of pregnancy, using the values ​​of alpha-fetoprotein (AFP). If the value is very low, this may indicate an increased risk of a chromosome disorder.

In addition, your blood is also being tested for the hormones estriol and HCG (human chorionic gonadotropins). Finally, your age is included in a calculation model - and thus the level of risk is determined. The AFP test is thus not a diagnosis, but only reflects the probability.

The AFP test detects 60-70% of fetuses with trisomy 21. This is less than the first trimester test ETT.

What happens if the result is conspicuous?

The AFP test does not say anything about whether your child really has Trisomy 21 or not. He can only measure the risk or the amount of opportunity. Basically, a value of 1: 380 and higher is considered conspicuous. But even a score of 1:10 does not mean that your child has a chromosome disorder, as 9 out of 10 children are healthy with this constellation. Conversely, however, also includes a very low risk such. For example, 1: 1200 is not anomaly.

At increased risk, amniocentesis (amniocentesis) is recommended.

Should I do an AFPplus test?

An AFPplus test only makes sense if you have not previously performed a nuchal translucency measurement with or without a blood test (first trimester screening ETT), chorion biopsy, or amniocentesis.

In multiple pregnancies, vaginal bleeding or if you already have a child with chomosome disorders, the test can not help.

Who pays the AFPplus test?

In Germany, the health insurance funds are not obliged to pay the test, ask for. In Austria, the cash registers do not cover the costs. In Switzerland, the AFPplus test is paid by the health insurance companies.

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