Green fluorescent protein (hGFP-S65T) was expressed in transgenic mice under the control
of the astrocyte-specific glial fibrillary acidic protein (GFAP) promoter. Tissues from
two independent transgenic Lines were ...

Hippocampal tissue from embryonic day 15-17 fetal mice, euploid or trisomic for
chromosome 16, was transplanted into the striatum or the lateral ventricle of 6-8 week
old female C57B1/6 mice. After 6-14 months of survival, ...

In the course of characterizing the distribution of putative catecholaminergic neurons
in the brain of the common marmoset, we encountered a population of such cells in the
basal forebrain. Tyrosine hydroxylase-immunoreactive ...

The expression mechanism of long-term potentiation (LTP) remains controversial. Here we
combine electrophysiology and Ca2+ imaging to examine the role of silent synapses in LTP
expression. Induction of LTP fails to change ...

The importance of several factors influencing the survival of cholinergic-rich embryonic
tissue transplanted to the adult rat forebrain and the extent of
acetylcholinesterase-positive fibre innervation of the host brain ...

The cholinergic projection from the nucleus basalis magnocellularis to the neocortex has
been implicated in normal memory function and in the dementia of Alzheimer's
disease. In order to investigate functions of this ...

It has been known for several years that stimulus-evoked metabolic activity is reduced
in the somatosensory cortex of animals with basal forebrain lesions that deplete the
neocortex of acetylcholine (ACh). During ...

Consideration of the ethical, social, and policy implications of research has become
increasingly important to scientists and scholars whose work focuses on brain and mind,
but limited empirical data exist on the education ...

The distribution of neurones that could be stained immunohistochemically with antibody
to the p75 neurotrophin protein was studied in the forebrain of the common marmoset, The
p75-immunoreactive forebrain cells appear ...

The induction of long-term potentiation (LTP) in the dentate gyrus of the hippocampus is
associated with a rapid and robust transcription of the immediate early gene Zif268. We
used a mutant mouse with a targeted disruption ...

Electron microscopic immunocytochemical methods were used to determine the localization,
subcellular distribution and expression of activity-regulated cytoskeletal protein
(Arc/Arg3.1) in dentate gyrus after unilateral ...

Monkeys with bilateral transections of the fornix were severely but selectively impaired
at learning visuospatial conditional tasks presented in a Wisconsin General Test
Apparatus. Bilateral transplantation of cholinergic-rich ...

Synaptic plasticity is an underlying mechanism of learning and memory in neural systems,
but it is controversial whether synaptic efficacy is modulated in a graded or binary
manner. It has been argued that binary synaptic ...