Character is what she / he fights

I'm looking for manga / anime where the main character is the non-human race that she or he fights against.Preferably the characters are unaware of their circumstances.The plot must be serious, so no comedies or anything light-hearted. No typical shoujo demon king/poor human romance or anything like that.If Yaoi, mark as such.

Examples:

Spoiler (mouse over to view)

Blood+: Main character is a queen of the beings she is made to fight against.Mahou Shoujo Madoka Magica: The Witches are just "developed" Magical Girls.

Spoilers.There is some comedy being a shounen and all, but when it chooses to get serious....Either the manga or the anime is good, but I think the full blown effects of this sort of thing are better in the anime.

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Yu Yu Hakusho But it only "half" counts

What about Trinity Blood? Not the manga though...

I'll edit this post if I can think of anymore.

________________I like my men androgynous. I like my women androgynous.