Schedule

Audience/Benefits

The audience for this workshop is faculty and graduate students in the feedback control systems area. Persons interested in development of new theory, driven by new application areas, or in expansion of the application areas themselves will benefit from exposure to this new area of research for control systems.

Reference

Of particular relevance to this workshop is
Kevin M Passino, “Humanitarian Engineering: Creating Technologies That Help People,” Edition 2, Bede Pub., OH, 2015.
Free download, 735 pages, with Matlab code: https://hebook.engineering.osu.edu
For more information on project activities in the area of this workshop, see: http://www.ece.osu.edu/~passino/
Activities of the IEEE Control Systems Society (CSS); was an elected member of the IEEE Control Systems Society Board of Governors; was the Program Chair of the 2001 IEEE Conf. on Decision and Control; was a Distinguished Lecturer for the IEEE CSS, and is currently a Distinguished Lecturer for the IEEE Society on Social Implications of Technology. He is the Program Chair for the IEEE CSS MSC’16 conference, for the Intelligent Control part. He is a Distinguished Member of the IEEE CSS. He is a Fellow of the IEEE.
He is co-editor (with P.J. Antsaklis) of the book "An Introduction to Intelligent and Autonomous Control," Kluwer Academic Press, 1993; co-author (with S. Yurkovich) of the book "Fuzzy Control," Addison Wesley Longman Pub., 1998; co-author (with K.L. Burgess) of the book "Stability Analysis of Discrete Event Systems," John Wiley and Sons, NY, 1998; co-author (with V. Gazi, M.L. Moore, W. Shackleford, F. Proctor, and J.S. Albus) of the book "The RCS Handbook: Tools for Real Time Control Systems Software Development", John Wiley and Sons, NY, 2001; co-author (with J.T. Spooner, M. Maggiore, R. Ordonez) of the book "Stable Adaptive Control and Estimation for Nonlinear Systems: Neural and Fuzzy Approximator Techniques," John Wiley and Sons, NY, 2002; author of "Biomimicry for Optimization, Control, and Automation," Springer-Verlag, London, UK, 2005; co-author (with V. Gazi) of the book "Swarm Stability and Optimization", Springer-Verlag, Heidelberg, Germany, 2011; and author of “Humanitarian Engineering: Creating Technologies That Help People,” 2nd Edition, Bede Pub., OH, 2015.-->

Abstract

Type 1 Diabetes (T1D) is an autoimmune disease leading to the destruction of the insulin-producing β- cells of the pancreas and metabolic imbalanced, characterized by the lack of capacity of the body to regulate blood glucose concentration. Therefore, patients suffering for such condition present chronic hyperglycemia that leads to a number of critical health complications including micro and macro vasculature such as limb loss, blindness and ischemic heart disease, just to cite a few. In addition periods of hypoglycemia, moderate and severe, can occur that can lead to coma, and even dead. Until now, the traditional approach for the management of diabetes, based on multiple daily subcutaneous insulin injections, has shown to be deficient in preventing short and long term complication associated with the disease. Based on the aforementioned, research efforts have been devoted in recent years to overcome the limitations of the traditional medical practice. Although the idea of a closed-loop control system (CLC), can be traced back to more than forty years ago, technological advances in the last decade such as subcutaneous continue glucose sensor (CGM) and programmable insulin pump have enable practical CLC approaches and lead to clinical validation of more efficient insulin therapies. CLC systems, also known as artificial pancreas (AP), are based on a feedback control designs for computing in real-time optimal insulin doses, based on mathematical models of diabetic metabolism.

Workshop objectives

The workshop objectives are (i) to provide to the control community a tutorial overview of the recent advances in the field of signals, modeling and control for diabetes care and (ii) to stimulate interaction
between the control community and the medical/biomedical industry community on the subject of diabetes care. In order to meet such objectives, the workshop organizers have brought together speakers taken among the most renowned leading experts in the areas of modeling and control for diabetes care. The proposed lectures will span, in a didactic way, some of the most significant aspects of the problem ranging from modeling of the diabetic patient dynamics to closed-loop control and continuous glucose monitoring sensor design. Open problems representing challenging opportunity for the control/system identification research community will also be discussed.
By bringing together leading researchers in the fields of signals, modeling and control for diabetes care, including medical industry and medical academia speakers, the organizers propose a set of tutorial lessons aimed at: (i) review the fundamental aspects and difficulties related to the problem of signal, modeling and control for blood glucose regulation in patients affected by Type 1 diabetes; (ii) provide a report on the recent advances obtained in this field highlighting the crucial role played by control theory; (iii) provide to the control community a list of challenging open problems that still need to be solved in order to realize an effective artificial pancreas systems; (iv) where the field is right now in order to bring this technology to commercialization.

Workshop structure and contents

The workshop consists of two parts. The first part encompasses a set of tutorial lectures aimed at presenting the fundamental concepts and some recent results about signal, modeling and control for diabetes care developed by leading researcher in the field of control and biomedical engineering.The second part is explicitly devoted to show the point of view of the industrial and medical community on the subject.
The distribution of the lectures and time allocated will be as follow.

PART I: Signals, Modeling and Control for Diabetes Care: review of fundamental concepts and recent advances.
The first part consists of the 4 talks, 60 minutes each (45 minutes talk, 15 minutes discussion) listed below.

PART II: Signals, Modeling and Control for Diabetes Care: recent advances in the medical and industrial community.
The second part consists of the 4 talks, 60 minutes each (45 minutes talk, 15 minutes discussion), listed below.

Title: Auxiliary signals for the control of glycemia during and after exercise (M.Breton)
Title: Closed-Loop control for type 1 Diabetes (T1D): Overview of clinical studies in T1D pediatric population (D. Cherñavvsky)

( II.4) 4:45-5:45 Speaker: Apurv Kamath, MS.-Current state of AP commercializationTitle: Impact of Industry-Academia Collaboration in the Development and Commercialization of AP
Systems (Dexcom Perspective)

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