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• Currently, no consensually agreed-upon definition of “severe depression” exists • HAMD-17 and MADRS scores of 28–30 and 30+, respectively, are the most often utilized definitions of severe depression • The appellation “severe depression” is often employed imprecisely and interchangeably with treatment-resistant and chronic depression • Essential features of the definition of severe depression have included: symptom severity, severity dimensions (e.g., melancholia) and symptom status.

• Currently, no consensually agreed-upon definition of “severe depression” exists • HAMD-17 and MADRS scores of 28–30 and 30+, respectively, are the most often utilized definitions of severe depression • The appellation “severe depression” is often employed imprecisely and interchangeably with treatment-resistant and chronic depression • Essential features of the definition of severe depression have included: symptom severity, severity dimensions (e.g., melancholia) and symptom status.