Priority: Sur'Kesh

Head to the Annos Basin and cruise from the Mass Relay in the Pranas system to the small diplomatic ship fleet by the sun.

The Salarian and Krogan diplomats will argue in a cutscene, the latter of which will be Urdnot Wrex if you didn't kill him in Mass Effect. If you did kill Wrex, his brother Urdnot Wreav will appear in his stead. There is one RenegadeInterrupt moment in this conversation.

Sur'Kesh

Recommended Loadout and Squad

Mission Enemies

Deal out Power Points before starting this mission. Follow Padok Wiks to the panel at the far end of the loading bay when you start the mission.

Easter Egg: Feces Analyzer

You can activate a panel along the edge of this area a number of times to hear about a dozen unique responses from a Salarian at the controls. He eventually advises you to get your own Feces Analyzer.

Head into the green panel door after talking to Padok. You will meet with Mordin Solus here if he survived the Suicide Mission in Mass Effect 2. You can win some Paragon/Renegade points in the ensuing conversation -- up to 6.

After accessing the elevator, a bomb will detonate. Cross the room and use the other door. Once outside Cerberus will confront you. The Assault Troopers are easy targets, especially in this area with a good deal of cover. You can hang back and snipe them easily.

A Research Log along the right side of the first area with enemies discusses the Yahg as a Salarian bio weapon.

When you enter the next green panel door a Yahg will burst out of a door. The way is blocked by fire, so hop over the short wall and leap over the gap to continue.

Shotgun Spare Ammo - After the Yahg jumps out, you can pick this mod up just on the far side of the gap.

Quarantine Checkpoint 1

In the next area the Pod with the female Krogan will stop and Cerberus enemies will attack it. A Pod Integrity meter will show the damage they inflict on it in real time. You can stop the nearby Cerberus enemies form harming the pod by rushing it.

Datapad (Credits) - Across from the Pod is a Datapad.

Head to the rear of the area and take out enemies immediately threatening the pod before doing anything else. Now, clear out the remaining enemies, including a Centurian with regenerating shields. His blue health bar can be depleted with Overload among other things.

Move through the checkpoint and a dropship will appear with more Cerberus enemies. The next area contains another Centurian and many more Troopers.

At the top of the stairs you will encounter two new enemy types, Combat Engineers and their deploy-able Turrets. Overload and other Powers can reduce the blue shields, but fire-based Powers like Incinerate work best on the yellow Armor bars.

If you don't fully take out a Turret, an Engineer will repair it, so beware. The Turret's weapon fire is powerful too, so stay far away and behind cover while you attack.

Spare Parts (Credits) - Salvage a panel along the inside wall for some Credits.

The next door requires you to stand in front of it while a scanner scans you for a few seconds. Don't leave the beam or it will reset and the door won't open.

Medical Station - On the other side of the scanning door is a Medical Station.

The next room has two floors. Direct your Squad Members to stay put on the first floor while you travel to the top. Clear it out and you may be able to drop down behind a pair of Guardians that appear armed with shields.

Return to the ground floor for some very awesome loot before leaving through the door on the top floor.

Armax Asenal Greaves - In the destroyed lab with two floors and the first Guardians, this is on a lab table on the bottom floor.

Quarantine Checkpoint 2

After all the enemies are gone you can bypass the door on the second level. The next checkpoint is here. Quickly dispose of the enemies and then loot the area. You'll notice the Pod Integrity meter has returned and it is not refilled. It's very important to stop enemies from damaging it in the rear of the area.

You now need to activate a Power ;Terminal that's in a dead end past the Quarantine Checkpoint. While doing this, make a sweep for some very nice loot in the area, including two very unique weapons you don't want to miss.

M-13 Raptor - Just as you enter the area with Quarantine Checkpoint 2, turn right and you will find a balcony with this Sniper Rifle on it. This unusual Sniper Rifle can fire shots without reloading at the expense of damage.

Pistol Scope - You can pick up this Weapon Mod in the red-lit area on the inside portion of Quarantine Checkpoint 2.

A Research Terminal is nearby the Pistol Scope as well.

Medical Station - Back by the Power Terminal switch in the rear of the area is a Medical Station.

Scorpion - This incredibly useful Heavy Pistol is on the ground in the back area with the Power Relay switch you must hit. It's very easy to miss, but the cool sticky shots it fires make it a great addition to your arsenal. However, where it REALLY comes in handy is as a weapon for a Squad Member. With the Squad Member's great accuracy and essentially infinite ammo, this will make for some excellent backup.

After turning on the power another wave of enemies will attack. After this, you can activate the Quarantine Checkpoint -- and then ANOTHER wave comes.

A door adjacent to the one you used to enter the area leads to a new area. Hop over the gap and go up the stairs to the final checkpoint.

Quarantine Checkpoint 3

Two Centurians will rush you here while the other enemies take shots at the Female Krogan. Focus on the Centurians from the safety of cover above the area. Your Pod Integrity should hold out until you can get to the lesser enemies around the door. Throw everything you've got at them but SAVE YOUR GRENADES if you have them.

The Atlas Mech is a massive, dangerous enemy. A direct hit from its missile launchers will take your shields out completely.

The pod holding its driver is vulnerable, and you can actually shatter the pod and kill the occupant -- later in the game you can even hijack the mech, but you can't at this juncture. Focus on using the right powers to take out first its Shields (blue) and then its Armor (yellow).

Note that throughout the first any type of grenade you may have handy will stagger the mech and do some damage. They are very, very useful.

Use things like Overload and Disruptor Ammo to get through the Shield. After this you can turn to Incenerate, Warp, Warp Ammo, Armor Piercing Rounds and Incendiary Rounds to get through the tough Armor. As mentioned above, once you get it down to just armor, you can shatter the pod and then snipe the occupant if you wish. Deplete the yellow armor meter and the mech will fall.

Unfortunately, there are still plenty of enemies that remain for you to eliminate. They are merely Assault Troopers, but don't get cocky! The mission will end after they are all disposed of.

Post-Mission Wrap Up

After Priority: Sur'Kesh you can start a number of Side Quests among other activities.