MITRAL VALVE INCOMPETENCE Clinical Trials and Studies

Treatments might be new drugs or new combinations of drugs, new surgical procedures or devices, or new ways to use existing treatments. The goal of clinical trials is to determine if a new test or treatment works and is safe. Clinical trials can also look at other aspects of care, such as improving the quality of life for people with chronic illnesses. People participate in clinical trials for a variety of reasons. Healthy volunteers say they participate to help others and to contribute to moving science forward. Participants with an illness or disease also participate to help others, but also to possibly receive the newest treatment and to have the additional care and attention from the clinical trial staff.

Number of patients recommended for sinus surgery after 3 weeks of antibiotic therapy; Number of patients recommended for sinus surgery after 6 weeks of antibiotic therapy; Change in Quality of Life after 3 weeks of antibiotics; Change in Quality of Life after 6 weeks of antibiotics; Change in Nasal endoscopy scores after 3 weeks of antibiotics; Change in Nasal Endoscopy Score following 6 weeks of antibiotics; Change in CT Score after 3 weeks of antibiotics; Change in CT Score after 6 weeks of antibiotics; Number of patients with antibiotic side effects after a 3 week course of antibiotics; Number of subjects with antibiotic side effects after a 6 week course of antibiotics

Duration of continuous daily symptoms of the acute respiratory infection diagnosed at the study entry.; duration (days)and severity (grade mild, severe) of different symptoms (clear nasal discharge, coloured nasal discharge, nasal obstruction, cough, throat pain, ear ache, fever, headache, diarrhea); number of days the child is using the following symptomatic drugs (pain killers, nasal vasoconstrictors, nasal corticosteroids, asthma drugs, antihistamines); number of days the child is not at school and that the parents are not at work

Number of participants receiving a prophylactic dosage with amoxicillin-clavulanate i.v. with bacteremia following dental extractions; Number of participants receiving a prophylactic dosage with amoxicillin i.v. (following the American Heart Association´s guidelines) with bacteremia after dental extractions

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