The Holiday Inn Express Hotel & Suites in O'Fallon, MO is located just west of St. Louis. Our hotel is convenient to Interstate 40 and I-64 and is near several local attractions and businesses, making it the perfect hotel for travelers looking for lodging in O'Fallon.

Conveniently located near major companies such as Citi Corporation, General Motors, Mastercard, APC, Nordyne, the Missouri Research Park and Progress West
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Our new O'Fallon, Missouri hotel offers comfort and convenience.

The Holiday Inn Express Hotel & Suites in O'Fallon, MO is located just west of St. Louis. Our hotel is convenient to Interstate 40 and I-64 and is near several local attractions and businesses, making it the perfect hotel for travelers looking for lodging in O'Fallon.

Conveniently located near major companies such as Citi Corporation, General Motors, Mastercard, APC, Nordyne, the Missouri Research Park and Progress West Hospital, our O'Fallon, MO hotel is ideal for area business travelers. You can take advantage of our meeting room and 24-hour business center, enjoy the convenience of a free local shuttle and stay connected with free high-speed Internet access.

Leisure travelers in O'Fallon will enjoy staying at our hotel as they explore everything the St. Louis area has to offer. We are just minutes from historic St. Charles, Six Flags Over Mid-America and the Augusta vineyards. The St. Louis Arch, Anheuser-Busch, Laclede's Landing and the stadiums of the Cardinals and the Rams are just a short drive into St. Louis from our hotel in O'Fallon.

Guest Reviews

Rated 5.0 out of 5.0 by wheez74 great stop
The newly remodeled rooms were very nice and comfortable. The staff was very helpful and very polite. Will stay here again when passing thru.
March 1, 2015

Rated 5.0 out of 5.0 by shorty63 great service
nice enjoyed my stay. Only problem is bathroom mirror is to high for wheelchair people. would like one the door to see better.
February 28, 2015

Rated 3.0 out of 5.0 by thunder14 Staff helpful
was a little disappointed upon learning they were under construction we were on the 3rd floor and had the only ice machine in use. Staff was nice and helpful. The breakfast was good though.
February 22, 2015

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