Florida's 2nd congressional district is a congressional district in the U.S. state of Florida. The district consists of the eastern part of the Florida Panhandle along with much of the Big Bend region along the Emerald Coast. It straddles both the Eastern and Central time zones. It is anchored in Panama City and includes many of the suburbs of Tallahassee, the state capital. With 49% of its residents living in rural areas, it is the least urbanized district in the state, and voters are generally conservative.

This changed as a result of a court-ordered redistricting that took effect for the 2016 election, following a lawsuit that challenged the district as gerrymandered, preventing African Americans from being able to elect representatives of their choice although they comprised a significant part of the population in the state. Under the new definition, most of Tallahassee, along with nearly all of the 2nd's black residents, were drawn into the 5th District.

To make up for the loss in population, the 2nd was shifted slightly to the south to take in territory previously in the nearby 3rd and 11th districts.

On paper, the redrawn 2nd (as it appeared in 2016) would have given Mitt Romney 64 percent of the vote in 2012, making it on paper the third-most Republican district in the state.[7] But the new 2nd was more than 12 points more Republican than its predecessor. Romney had carried the old 2nd in 2012 although he received only 52 percent of the vote.[8]