GeneCards Summary for SPRR2B Gene

UniProtKB/Swiss-Prot for SPRR2B Gene

Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane.

Molecular function for SPRR2B Gene

Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane.

Structural organization and regulation of the small proline-rich family of cornified envelope precursors suggest a role in adaptive barrier function.(PMID: 11279051)Cabral A. … Backendorf C.(J. Biol. Chem. 2001)3464