4-8-8-4 Big Boys were only produced for the Union Pacific Railroad. Twenty-five such engines were built between 1941 and 1944, numbered 4000 to 4024. Eight of these locomotives survive, seven of which are on static public display at various sites in the United States. Union Pacific announced plans in August 2013[1] to restore No. 4014 to operation for use in mainline excursion service. No. 4014 is currently undergoing restoration, and is expected to be operational by 2019.[2]

The UP Big Boys were an expansion of the 4-6-6-4 "Challenger" type articulated locomotive. Although their wheels were an inch (25 mm) smaller than those of the Challengers, they were still able to sustain high speeds. Adding four driving wheels increased the pulling power of the locomotive and reduced the need for helper locomotives over steep grades.

Other American railroads considered buying 4-8-8-4s, including the Western Pacific Railroad, which already rostered large 2-8-8-2s and 4-6-6-4s, but diesel locomotives were gaining popularity and soon were able to displace these Big Boy locomotives.