Human Apolipoprotein C-II (APOC2) Interaktionspartner

The results demonstrate the important role of both intra- and inter-subunit charge interactions in stabilizing apoC-II amyloid fibrils, a process that may be a key factor in determining the general ability of proteins to form amyloid fibrils.

The results highlight the importance of charge-pair interactions within the apoC-II fibril core

Mutations in GPIHBP1 (zeige GPIHBP1 Antikörper) are rare but the associated clinical phenotype of hypertriglyceridaemia is severe

These results support a predictive change in the ratio of plasma ApoCIII (zeige APOC3 Antikörper) to ApoCII in pregnancies complicated by severe preeclampsia.

Mouse (Murine) Apolipoprotein C-II (APOC2) Interaktionspartner

A novel mouse model of apoC-II deficiency was created with an apoC-II peptide that reverses the hypertriglyceridemia.

Data show that apoC-II and LPL (zeige LPL Antikörper) mRNAs correlate temporally and geographically with surfactant lipid synthesis in preparation for birth and suggest that fatty acid recruitment from the circulation by apoC-II-activated LPL (zeige LPL Antikörper) is modulated by apoC-II secretion.

Apolipoprotein C-II (APOC2) Antigen-Profil

Protein Überblick

This gene encodes a lipid-binding protein belonging to the apolipoprotein gene family. The protein is secreted in plasma where it is a component of very low density lipoprotein. This protein activates the enzyme lipoprotein lipase, which hydrolyzes triglycerides and thus provides free fatty acids for cells. Mutations in this gene cause hyperlipoproteinemia type IB, characterized by hypertriglyceridemia, xanthomas, and increased risk of pancreatitis and early atherosclerosis. This gene is present in a cluster with other related apolipoprotein genes on chromosome 19. Naturally occurring read-through transcription exists between this gene and the neighboring upstream apolipoprotein C-IV (APOC4) gene.