Sex matters: Drugs can affect sexes differently - CBS News

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"How did it happen that for 20 some years, women, millions of them, were essentially overdosing on Ambien?"

Dr. Sandra Kweder: So if I took Zolpidem, and my brother took same dose, probably the maximum level of drug in my blood would be 45 percent higher than his maximum blood level.

Lesley Stahl: Now that sounds substantial—

Dr. Sandra Kweder: It is substantial.

But we discovered that that 45 percent difference between men and women had been known to the FDA all along. In the original FDA review of Ambien back in 1992, there was a page called “Effect of Gender,” where the FDA reviewer noted that two key measures of how much drug is in the bloodstream “were approximately 45 percent higher in females than in males.”

This has been needed for a long time, also we should be dosing on size too ie a 85lb female probably shouldn't be taking the same dose as a 325lb male.

The only dosing that has historically been more specific is pediatric; which is based on the weight of the child.

There has been a little bit of interest in using Compounding Pharmacies; which make a medicine specifically for one person, but the only thing I've personally heard of it being used for the most, is Hormone Replacement Therapy, but I guess it is used for quite a bit of reasons, but does usually cost more than traditional drugs.

Compounding Pharmacies per Wikipedia

Patients with unique or unusual medication needs
Physicians may prescribe an individually compounded medication for a
patient with an unusual health need. This allows the physician to tailor
a prescription to each individual. Compounding preparations are
especially prevalent for:

Patients requiring limited dosage strengths, such as a very small dose for infants

Patients requiring a different formulation, such as turning a pill into a liquid or transdermal gel for people who cannot swallow pills due to disability

Children who want flavored additives in liquid drugs, usually so that the medication tastes like candy or fruit

Veterinary medicine, for a change in dose, change to a more
easily-administered form (such as from a pill to a liquid or transdermal
gel), or to add a flavor more palatable to the animal. In the United
States, compounded veterinary medicine must meet the standards set forth
in the Animal Medicinal Drug Use Clarification Act (AMDUCA)[4][7]