A thermal cycler (also called thermocycler) is an instrument that employs precise temperature control and rapid temperature changes to conduct the polymerase chain reaction (PCR). PCR is used to create billions of copies of a DNA sequence for use in a wide array of downstream procedures including cloning, sequencing, expression analysis, and genotyping. Our engineers have been designing and manufacturing high-quality Applied Biosystems® thermal cyclers since 1987; these instruments are renowned for their reliability, accuracy, and user-friendly interfaces.