That’s not to
say that it doesn’t have its unnerving moments. The hangar where
you first find the Crozier shuttle (with all the exploders) is
rather scary, but only because the creepy string music doesn’t ever
end while you’re in the room. So is the first time you encounter
Feeders, but you soon learn they aren’t really anything to fear if
you can find a choke point and have an automatic weapon.

The Regenerators
are always frightening, but they are only scary because they are
un-killable. And with the weapons you can make now days…more on
that later

The Creeper
(divider head) and Swarm deaths end in Isaac becoming a Necro, and
are genuinely disturbing.