AA and DHA are the most vulnerable targets for free radical-catalyzed lipid peroxidation. Docosanoids/neuroprostanes, are oxidation products of DHA. The compounds 4-hydroxy-2-hexenal/neuroketals, remain esterified to phospholipids, significantly inhibit proteasome, and are highly cytotoxic. This oxidative damage can lead to docosanoid-induced neurodegeneration, and is associated with neurodegenerative disease.

AA and DHA are the most vulnerable targets for free radical-catalyzed lipid peroxidation. Docosanoids/neuroprostanes, are oxidation products of DHA. The compounds 4-hydroxy-2-hexenal/neuroketals, remain esterified to phospholipids, significantly inhibit proteasome, and are highly cytotoxic. This oxidative damage can lead to docosanoid-induced neurodegeneration, and is associated with neurodegenerative disease.