Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain linked by a disulfide bond. Alpha-V (ITGAV) associates with either beta-1 (ITGB1), beta-3 (ITGB3), beta-5 (ITGB5), beta-6 (ITGB6) or beta-8 (ITGB8). Interacts with RAB25. Interacts with CIB1. Integrins ITGAV:ITGB3 and ITGAV:ITGB5 interact with FBLN5 (via N-terminus) (By similarity). Alpha-V/beta-6 and alpha-V/beta-3 bind to foot-and-mouth disease virus (FMDV) VP1 protein and acts as a receptor for this virus (PubMed:10906183, PubMed:12551988). ITGAV:ITGB3 and ITGAV:ITGB5 interact with NOV.
UniProt

Sequence Mismatches It is now possible to see information about expression tags, cloning artifacts, and many other details related to sequence mismatches.
Icons represent a number of different sequence modifications that can be observed in PDB files. For example the 'T' icon
T
represents expression tags that have been added to the sequence.
The 'E' icon
E
represents an engineered mutation. However, besides these two, there are many other icons. For more information about the meaning and exact position of a sequence modification, move the cursor over the icon.
Validation Track