Trafficking of Systemic Fluorescent Gentamicin into the Cochlea and Hair Cells

@article{Wang2009TraffickingOS,
title={Trafficking of Systemic Fluorescent Gentamicin into the Cochlea and Hair Cells},
author={Qi Wang and Peter S Steyger},
journal={Journal of the Association for Research in Otolaryngology},
year={2009},
volume={10},
pages={205-219}
}

Aminoglycosides enter inner ear hair cells across their apical membranes via endocytosis, or through the mechanoelectrical transduction channels in vitro, suggesting that these drugs enter cochlear hair cells from endolymph to exert their cytotoxic effect. We used zebrafish to determine if fluorescently tagged gentamicin (GTTR) also enters hair cells via apically located calcium-sensitive cation channels and the cytotoxicity of GTTR to hair cells. We then examined the serum kinetics of GTTR… CONTINUE READING