The position offers an exciting opportunity to engage in the discovery and preclinical development of protein therapeutics for unmet medical needs. You will be the key player of research and development group and perform hands-on protein/antibody engineering activities to support discovery and development of therapeutic proteins, monoclonal antibodies and bispecifics. The primary responsibilities include obtaining in-depth knowledge of the therapeutic proteins of interest and using this information for protein generation and technology development. This includes protein/antibody engineering, expression and purification and subsequent antibody generation. He/she will be responsible for designing and cloning various antibody formats (scFvs, Fabs, full length and bi-specific IgGs) into mammalian expression vector systems. He/she will need to work closely with the others to evaluate and characterize these proteins in a variety of in vitro and in vivo models and use these results to further engineer the antibodies to maximize their therapeutic potential.

Job Duties: To develop and generate cell lines and animal models with precise genome modifications using genome editing methods and tools. This is a hands-on lab-based role at the forefront of the Genome Editing technology and/or induced pluripotent stem cells (iPSCs) technology with a focus on effective delivery, troubleshooting and putting ideas into action. Provides support, supervision and coaching to scientists, ensuring that methods run efficiently and correctly, developing and guiding the set-up of new methodologies.

Extensive hands-on animal model/iPS cell line generation experience using a variety of methods, including genome editing tools (ZFN, TALEN and CRISPR /CAS9) on a variety of cell types or animals.

Innovative publications and excellent oral and written communication skills and organizational skills

Accountabilities

To have strong collaboration skills

To work independently to contribute to the design and analysis of experimental procedures by incorporating the views of others

To interpret experimental data and play a significant role in the planning of further experiments.

To maintain an awareness of current developments in the literature.

To identify and solve problems associated with their experiments.

To conduct where appropriate in parallel more than one agreed area of work to agreed timelines.

Requirements:

Ideally should have a M.S. or Ph. D. degree or corresponding experience in a relevant scientific discipline with several years of relevant experience in genetic modification for hiPS cells, primary cells and transgenic animals

Microinjection specialist

Job Location: Milpitas, CA and Mountain View, CA

The incumbent will play a key role in our animal science group. Responsibilities include but not limited to 1) oversee mouse and rat transgenic model projects; 2) conduct microinjection of DNA and embryonic stem cells; 3) manage 10 to 20 service projects; 4) in charge of administrative duties, such as interacting with facility management, ordering animal and scheduling injection; 4) in charge or assist other animal handling procedures, such as surgery, drug administration, tissue sample collection, animal shipping, etc.. The incumbent may be involved in regular lab duties when necessary.

Qualifications:

Master's degree in biological sciences with a minimum of three year of microinjection experience.

Job Location: Milpitas, CA The candidate will use state-of-the-art equipment to identify transgenic animals and optimize the current technique in detecting transgene, design and prepare the materials for experiment, conduct scientific equipment to identify the transgene mice using molecular knowledge, record results from experiment, modify, test, verify and analyze data to determine next steps, compile research data, discuss with manager about completed projects and revise and develop the protocols in order to complete a research project.

The incumbent will work in our animal science group. Responsibilities include but not limited to 1) order animal according to scheduled microinjections; 2) conduct routine procedures for animal preparation before and after microinjections, such as hormone injections and animal suture; 3) collect tissue samples for service and R&D projects; 4) manage mouse and rat cages for service and R&D projects; 5) maintain lab supplies and prepare routinely used reagents; 6) in charge of animal transfer domestically and internationally; 7) participate in project management under senior group members’ supervision.