Tigers starter Anibal Sanchez gave up nine runs and 11 hits in five innings.

Castro connected for his sixth homer and Ankiel his fourth. Ankiel drove in four runs for Houston and Ronny Cedeno had three hits and scored twice.

Fielder homered off Houston starter Philip Humber, who pitched six innings and allowed four unearned runs.

The Astros will play two weekend games in Houston against the Chicago Cubs before opening their first season as a member of the American League on Sunday night against the Texas Rangers.

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