MEMRI
Study of Neonatal Hypoxic-Ischemic Injury in the Late Stage

1Laboratory of Biomedical and Signal
Processing, The University of Hong Kong, Hong Kong SAR, China; 2Department
of Electrical and Electronic Engineering, The University of Hong Kong, Hong
Kong SAR, China

In this study, in vivo MEMRI was employed to
investigate the hypoxic-ischemic injury in the late phase. Mn2+ induced signal
changes were examined using SPM coregistration and ROI analysis. T1WIs SI
increase was detected in the perilesional region 24 hours after Mn2+
administration and it colocalized with the increase in glial cell density in
GFAP staining, demonstrating the existence of reactive gliosis in the late
phase after H-I injury.