Activated T-cell therapy

We at DiponEd isolate and expand the T cells from peripheral blood. The T cells are then reengineered in our laboratory to produce genetically engineered chimeric antigen receptors (CARs) on their surface, which allow the T cells to recognize an antigen on targeted tumor cells. These genetically modified T cells are grown in our facility for its ‘expansion’ until hundreds of millions of the modified T cells are available.

Through an intravenous infusion, patients receive these T cells, which possess the ability to attack and kill the cancerous cells. These cells may remain in the body long post infusion and may continue to guard against cancer recurrence. There is generally little or no risk of toxicity as the active ingredient is patient’s own white blood cells.

Adoptive T-cell therapy

At DiponEd, we follow novel methods for the isolation and ex-vivo enrichment and expansion of tumor-specific T cells from tumor biopsy samples. The tumor-specific T cells are then infused in to cancer patients with a goal to give their immune system the ability to overwhelm remaining tumors via T cells which can attack and kill cancer.

NK cell therapy

Natural Killer (NK) cells are cells of lymphoid origin that play key roles in eliminating host viral infections as well as the development of tumor cells. NK cells are especially important because cancer cells with missing MHC I markers can be detected and destroyed by NK cells.

Our activated and engineered Natural Killer (NK) platform has the ability to destroy cancer and virally infected cells from the body. Using our proprietary manufacturing and distribution processes, NK cells are grown uniquely that selectively target and kill the diseased cells.

DC therapy

Adult Stem Cell Transplantations

Cellular/Tissue Transplantation

Mesenchymal stem cells

Normal Human Bone Marrow-Derived Mesenchymal Stem Cells (hMSC) have been reported to differentiate down to many different lineages including chondrogenic, osteogenic, adipogenic and neural precursor cells. Many clinical trials have demonstrated the efficacy of MSC infusion for diseases including acute myocardial ischemia (AMI), stroke, liver cirrhosis, amyotrophic lateral sclerosis (ALS) and GVHD.

DiponEd BioIntelligence offers a large scale expansion of allogeneic mesenchymal stem cells from cord blood or bone marrow. Our mesenchymal stem cells are derived from human umbilical cord tissue/bone marrow aspirates from qualified, donors. The isolated cells are cultured and expanded in compliance with GMP manufacturing standards in our cell culture lab. We follow all the safety procedures and guidelines in handling all the cell lineages from tissue isolation to preservation and culturing. Human Mesenchymal Stem Cells (hMSC) are isolated and cryopreserved in the second passage to ensure the highest viability and plating efficiency.

Melanocyte culture

At DiponEd, we isolate the primary human epidermal melanocytes from lightly pigmented tissue, culture in GLP/GMP compliant cell culture lab and are cryopreserved. Upon thawing, our cultured cells are guaranteed to be of >70% viability. Melanocyte cell cultures are optimized to synthesize melanocyte cells which can be used for the treatment of vitiligo. No risk of side effects is associated with it as the epidermal grafts are obtained from patient’s own skin.

Hair Follicular Stem Cell Culture for Hair Transplant

Hair loss is a common problem, especially at an early age that not only results into most frequent visits to dermatologists but also profoundly affects one’s quality of life. Stem cell therapy is one such efficient treatment that has unleashed an altogether different approach to stimulating hair growth. The hair follicle has stem cells at the center of the follicle that ensure the continuous supply of cells, thereby helping in multiplication of hair cells on a fast pace treating hair loss or baldness.

We at DiponEd focus on the collection of stem cells from the patient’s own hair follicles, where the follicles are processed and cultured hair follicular stem cells are delivered to medical facility for use in transplantation therapy for the patient.

Cryopreservation

Predictive and Prognostic Systems

Genetic predispositions

CAN-DETECTTM – Genetic Predisposition Cancer Screening

DiponEd’s genetic analysis wing offers a simple solution for taking proactive measures to better understand the personal risk of developing cancer. Estimates suggest that 10-15% of most cancers in women and men are due to inherited genetic mutations. A mutation can greatly increase your risk for developing cancer. For example, a BRCA1 mutation can increase a woman’s chance of developing breast cancer up to 81% by age 80. Knowing that you have a mutation in one of these genes, BRCA1 and BRCA2, which increases your risk of developing cancer, enables you and your healthcare provider to create a personalized screening plan that increases the chance of early detection. Scientists at DiponEd stay alongside of changes in the field of cancer and genetics so that nothing goes undetected and all types of cancer can be treated at an early stage. The CAN-DETECTTM analyzes your genes to help you understand the probable risk for the most common cancers.

Diagnostic Health Tests includes

Heavy Metals & Plasticizers Poisoning Detection Test:

Determines if metal toxicity or mineral deficiency.

Monitor the effects of chelation (elimination of heavy metals from the body).

Identify if supplementation of important minerals may bring about significant improvements.