UPDATED: "Guide" revolves around a family that's brought together by divorce, with Elfman playing the ex-wife opposite blind patriarch J.K. Simmons.

UPDATE: Elfman's deal is now closed for her to star.

Jenna Elfman is in talks to join NBC’s upcoming comedy The Family Guide.

She'd replaceParker Posey, who exited the single-camera project a day after it was ordered to series. Guide is about a son who idolizes his blind father (J.K. Simmons) and is bemused by the mother's newfound adolescence as he watches his family come closer together postdivorce. Elfman would play the ex-wife, oppositeSimmons.

The talks reunite Elfman with NBC’s comedy brass, who oversaw her most recent TV effort as the first lady in the network’s short-lived 1600 Penn. The new half-hour series will premiere midseason, paired with About a Boy in the coveted post-Voice hour on Tuesdays.

Guide hails from Up All Night's DJ Nash and executive producers Jason Bateman and Jim Garavente. The pilot was directed by Friends alum David Schwimmer.

Elfman, whose other TV vehicles include Accidentally on Purpose and Dharma & Greg, is repped by WME, Brillstein and O’Melveny & Myers.