The relationship between body composition and knee osteoarthritis in postmenopausal women

Hakan Nur 1 ,Tiraje Tuncer 1

1 Department of Physical Medicine and Rehabilitation, Medicine Faculty of Akdeniz University, Antalya, Turkey
DOI :
10.5606/tftrd.2018.1496
Objectives: The aim of this study was to examine the relationship between the body composition measures and knee osteoarthritis (OA) in
postmenopausal women to determine whether the fat mass or the lean mass was closely associated with knee OA.

Patients and methods: This retrospective, cross-sectional study included a total of 212 postmenopausal women (mean age 59.9±6.2 years;
range, 46 to 76 years). Descriptive characteristics were recorded and height was measured using a stadiometer. Body weight, fat mass, and
lean mass were estimated using bioelectrical impedance analysis. X-rays of the knees were obtained. Knee OA was radiographically diagnosed
according to the Kellgren-Lawrence criteria. Based on the radiographic knee OA diagnosis the women were divided into two groups. Logistic
regression analyses were used to examine the associations between the body composition measures and knee OA.

Results: Knee OA was present in 117 women. Body Mass Index, body weight, fat mass, and lean mass were all significantly associated with
knee OA after adjusting for confounding factors such as age, height, and physical activity (p<0.001). When assessed together with lean
mass in a multivariate regression model, fat mass was closely and significantly found to be related to knee OA, compared to lean mass
(p<0.001, OR: 1.17). Furthermore the fat mass/lean mass ratio was positively associated with knee OA (p<0.001).

Conclusion: In postmenopausal women body weight was significantly and positively associated with knee OA and among the components
that constitute body weight, fat mass was closely and significantly associated with knee OA compared to lean mass. This result suggests that
the relationship between obesity and knee OA is mainly based on the fat mass, and supports the importance of systemic metabolic effects of
adiposity in this relationship.