Core Members

Dr. Chiou-Hwa

喻秋華博士／國家衛生研究院分子與基因醫學研究所研究員

Dr. Chiou-Hwa (Cathy) Yuh is currently an Investigator at National Health Research Institutes and Associate Professor at National Tsing-Hua University and National Chiao Tung University. Dr. Yuh received her B.A. from Biology Division at Fu-Jen Catholic University, Taiwan in 1987, and received her Ph.D. from Institute of Microbiology and Immunology at National Yang-Ming Medical College, Taiwan in 1992. Dr. Yuh received the postdoc training at Biology Division in California Institutes of Technology starting 1992, under the direction of Dr. Eric Davidson. She decoded the regulatory circuit of endoderm specific gene in sea urchin, Endo16 and published the paper in Science on 1998, using computational algorisms to explain the transcription regulation. Dr. Yuh gained tremendous experience on the systematic approached of embryonic development and GRNs. Seventeen scientific high impact papers and three book chapters were published before she joined NHRI.

Dr. Yuh was recruited as an Associate Investigator by the DMGM of NHRI at December 31 of 2004, and started using zebrafish as model organism to decode the embryonic gene regulatory networks. Using a web-enabled GRN modeling tool (BioTapestry) to build an integrated model of the Endomesoderm Gene Regulatory Network in zebrafish, functional dissecting the important subcircuits in the endoderm networks by systematically approaches, she identified several interesting functional motifs that are important building blocks in zebrafish developmental GRNs, and published six papers on international well known journals such as Developmental Biology, BMC Developmental Biology and Birth Defects Research Part C. For the translational research, Dr. Yuh had found the genes and pathways in development were dysregulated in cancer. She initiated the systematic analysis of hepatocellular carcinoma (HCC) in mouse model, and established transgenic zebrafish model. Dr. Yuh has identified five critical oncogenes from mouse model, verified using human HCC specimens, and confirmed in transgenic zebrafish. For application, Dr. Yuh’s further develops the drug screening platform to identified novel small molecules which are effective in treatment HCC and lower toxicity compared to Sorafenib. Dr. Yuh has authored over 43 research and review papers in peer-reviewed professional journals including Science, PNAS, Development, Carcinogenesis and International Journal of Cancer, and contributed to 3 book chapters.

Dr. May-Su You

游美淑博士／國家衛生研究院分子與基因醫學研究所高級技術師

Dr. May-Su You is currently a Senior Specialist in The Institute of Molecular and Genomic Medicine of National Health Research Institutes. She received her BSc in Human Nutrition from Taipei Medical University, Taiwan and her Ph.D. from Institut fur Biologische Chemie und Ernahrungswissenschaft (Institute of Biological Chemistry and Nutrition Sciences), Universitat Hohenheim, Stuttgart, Germany. After one year postdoc training in the Lab of Fish Developmental Biology in the Institute of Molecular and Cell Biology, Singapore, Dr, You became the manager of Zebrafish Core Facility in IMCB in 2003. She established an 8000 tanks containing zebrafish facility from scratch and managed the facility with bio-coding system and SOPs. She initiated the zebrafish IACUC form in IMCB and provided services to all scientists within Biopolis, Singapore. Dr. You was recruited by the IMGM of NHRI as a Senior Specialist in 2008 to establish a zebrafish core facility for NHRI and NTHU. This joint core facility has become a National Zebrafish Core Facility from 2010 with NSC (National Science Council) grant support.

Under the management of Dr. You, the zebrafish facility of NHRI becomes an AAALAC International accredited facility in March 2015. Dr You’s expertise is in zebrafish husbandry, facility set-up and management. She is also actively involved in establishing platforms for biomedical research using zebrafish as a disease model, for example, toxicity test and behavior analysis.

Dr. Yun-Jin Jiang

江運金博士／國家衛生研究院分子與基因醫學研究所副研究員

Dr. Yun-Jin Jiang is currently an Associate Investigator in the Institute of Molecular and Genomic Medicine (IMGM), National Health Research Institutes (NHRI), Taiwan and an Adjunct Associate Professor in the National Taiwan University, Taipei and a Joint Associate Professor in the National Chung Hsing University, Taichung. Dr. Jiang received his BSc from the Department of Agricultural Chemistry, National Taiwan University in 1986 and MSc from the Institute of Biochemical Sciences, National Taiwan University in 1988. After two years’ military service as an Armor Second Lieutenant in the Taiwanese Army and two years employment as a Research Assistant in the Institute of Molecular Biology, Academia Sinica, Taipei, he went to Germany and earned his PhD from the Fakultat fur Biologie of Eberhard-Karls Universitat (Tubingen University) and worked in the laboratory of Frau Professor Dr. Christiane Nusslein-Volhard, in the Max-Planck-Institut fur Entwicklungsbiologie, Abteilung Genetik, Tubingen, Germany in 1997. He worked with other scientists in the first large-scale zebrafish screen during his PhD study. He carried out his postdoctoral training in the Laboratory of Dr. Julian Lewis in the Imperial Cancer Research Fund, London, UK, where he characterized the somite mutants and demonstrated that Notch signaling is essential for somite segmentation. In 2001, Dr. Jiang assumed his duty as a Senior Scientist in the Institute of Molecular and Cell, A*STAR, Singapore and further explored the functions of Notch signaling in zebrafish development. At the same time, he was an Adjunct Assistant Professor in the Department of Biochemistry, National University of Singapore, Singapore from 2003 and became an Adjunct Associate Professor in 2008. Dr. Jiang was recruited to IMGM/NHRI in 2009 and continued his work in studying signal transduction and vertebrate development by using zebrafish as a model. His recent interest is to use zebrafish model to explore human diseases, e.g. cancer and Alzheimer’s disease.

Dr. Jiang has authored more that 62 original research and review papers on topics including large-scale zebrafish genetic screen, zebrafish development, Notch signaling, somitogenesis, neurogenesis, hematopoiesis and functions of novel genes in relation to Notch signaling and DNA replication. These papers were published in journals including Nature, Developmental Cell, Trends in Cell Biology, Blood, Current Biology, Circulation Research, Oncogene, PLoS Genetics, Development, Molecular Biology of the Cell, BMC Genomics. In addition, he has written 4 book chapters. The h-index of his published work is 37.