In a comment to my post on putting out fires last week, one commenter mentioned the utility of the good old sand bucket, and wondered if there was anything that would go on to set the sand on fire.

I still work in the lab myself, although for obvious reasons I’ve never been in a position to blog about my day-to-day activities.

When we speak of the Hobbit, let us not forget her tools.

Although I write about a range of scientific topics (with a special focus on chemistry),drug discovery is its heart.

It’s a really interesting field, and a bizarrely difficult one: for example, I have never once worked on any compound that has made it all the way to the market, not in 26 years and counting.

And even once the antiquity of the remains was established, many scientists refused to accept that Neandertals could be closely related to modern humans, depicting them instead as brutish and apelike.

This interpretation reflected the prevailing prejudices about human ancestry, and was supported by misinterpretation of the remains of the "Old Man of La Chapelle", whose skeleton was warped by arthritis.

Virchow described it as the skeleton of a diseased Cossack cavalryman.

If you want to know how come your prescriptions cost so much, it’s me.

So you’ll hear a lot about the successes and the failure of this business, where it’s come from and speculations on where it might be going.

Over that time, I’ve worked on projects directed against schizophrenia, Alzheimer’s, diabetes, osteoporosis, many types of cancer, resistant gram-negative bacteria, and several nasty viruses (among others).

You may notice that we still have all these diseases with us, and that might be the best single reason for this blog’s existence.

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