The mutli-disciplinary Bioconversion-Chemistry-Engineering Interface
(BiCE) programme brings together academics from three UCL faculties
interested in the synthesis of the next generation of complex chiral
pharmaceuticals. The BiCE programme has two strategic goals:

The acceleration of biocatalytic process creation and optimisation

The integration of biocatalysis within atom efficient multi-step chemical syntheses

Key
research areas designed to meet these goals are listed below.
Collaborative doctoral and post-doctoral projects are currently
underway in each of these areas funded by a combination of BBSRC, EPSRC
and Technology Strategy Board awards.

Chemistry studies for the better integration of chemical and biocatalytic routes to single isomer chiral synthons

New microfluidic and microwell technologies for evaluation of multistep chemoenzymatic process options

Modelling tools to set biocatalyst engineering targets and to predict large scale process performance

The
BiCE programme focuses on the linkage of novel chemistries with
advanced bioconversions capable of stereoselective carbon-carbon bond
formation, amine group addition and selective hydroxylation and
oxidation.

Selected BiCE Publications

The UCL team have a proven track record of multidisciplinary
collaboration and co-publication. Listed below are selected recent
publications that contribute to delivery of the BiCE goals. Authors
indicated in bold represent members of the staff team.