Endoscopy capsule that emits a remotely variable, magnetic field, and examination apparatus with such an endoscopy capsule

Title: Endoscopy capsule that emits a remotely variable, magnetic field, and examination apparatus with such an endoscopy capsule.Abstract: An endoscopy capsule for examination and/or treatment in a hollow organ of a body has at least one magnetic element that interacts with an external magnetic field for externally controlled movement and/or rotation of the endoscopy capsule, and the magnetic field of the magnetic element can be varied by external control. ...

BACKGROUND OF THE INVENTION

The invention concerns an endoscopy capsule for examination and/or treatment in a hollow organ of a body, of the type having at least one magnetic element that interacts with an externally applied magnetic field for externally controlled movement and/or rotation of the endoscopy capsule, as well as an examination and/or treatment device embodying at least one such endoscopy capsule and a magnetic field generation device to generate the external magnetic field.

2. Description of the Prior Art

Endoscopy capsules for examination and/or treatment of a hollow organ, in particular the gastrointestinal tract, are known that can be administered to a patient and that then move through the body by means of natural peristalsis. With such endoscopy capsules, however, there are only a few possibilities to align the field of view of an image acquisition device provided at the endoscopy capsule on a desired target, or even to suitably position instruments. Also, there must be a waiting time for natural transport through the patient to occur.

Endoscopy capsules have consequently been designed that have a permanent magnetic element that interacts with an externally applied magnetic field so as to enable an externally controlled rotation and/or translation movement of the endoscopy capsule within the hollow organ by appropriate variation of the external magnetic field.

For example, an imaging method for an endoscopy unit of the capsule type is described in U.S. Pat. No. 7,343,036. A tube is used that has field coils for generation of a static magnetic field and field gradient coils with associated gradient amplifiers to generate gradients of the external magnetic field. One field coil and one field gradient coil for each of the three Cartesian spatial coordinates are respectively provided, so that a local change of the magnetic field in all spatial directions is possible. In this way an active control to wirelessly move the endoscopy unit is achieved by the externally variable magnetic field interacting with a permanent magnet of the endoscopy unit, for example in order to guide the endoscopy unit through the gastrointestinal tract of a patient. A display device is used in order to display the images that are transmitted wirelessly by the capsule-type endoscopy unit.

A system with a magnetically guided endoscopy capsule (MGCE) has been jointly developed by Siemens AG with Olympus Medical Systems Cooperation, that allows stomach examinations to be implemented simply and comfortably, because the patient must merely swallow the endoscopy capsule. The patient then lies inside the magnetic guidance system where a magnetic field generation unit is designed to generate a variable external magnetic field. The physician uses an operating device—in particular a joystick—in order to navigate the endoscopy capsule to the regions of interest. From there the endoscopy capsule can show high-resolution images of the inside of the body in real time at a display device in the examination room.

The design of a magnetic field generation device that can be used to move a magnetic object (for example a permanent magnet of an endoscopy capsule) in an operating region is disclosed in U.S. Pat. No. 7,173,507, for example. A magnetic coil system is described therein that can generate three magnetic field components Bx, By and Bz and five magnetic field gradients. These are used in order to navigate (meaning to rotate and/or to tilt and/or to move) a magnetic object without contact. A video endoscopy capsule that is provided with a permanent magnet thus can be navigated. The magnetic endoscopy capsule tends to orient parallel to the static direction of the external magnetic field. The field gradients produce a force on the permanent magnet of the capsule, which can be described as a magnetic dipole (in this regard see also the article by David C. Meeker et al., “Optimal realization of arbitrary forces in a magnetic stereotaxis system”, IEEE Transactions on Magnetics, Vol. 32, No. 2, March 1996, Pages 320-328). Through targeted activation of the individual coils, it is possible to vary the external magnetic field and thus to orient the endoscopy capsule arbitrarily in the operating region, and moreover to exert a predefined force on it in all directions, which means that the endoscopy capsule can be rotated and moved linearly.

In WO 2009/016207 A1 a magnetic coil system is described for generation of a force on an endoscopy capsule. The magnetically directed endoscopy capsule of the system is supplemented with an imaging device (preferably a magnetic resonance device), and the magnetic field generation device is expanded so that it allows low-quality (“low end”) magnetic resonance imaging and additionally drives the endoscopy capsule with a static magnetic dipole. The magnetic field generation device should simultaneously be able to generate a stable and homogeneous magnetic field for magnetic resonance imaging, wherein the gradient coils that are used for force generation on the endoscopy capsule are also used for the magnetic resonance.

However, this known system has a number of disadvantages. The strong external basic magnetic field that is required for magnetic resonance imaging will basically flip the endoscopy capsule in the direction of the field and can thus make the endoscopy capsule navigation impossible. The positioning of the endoscopy capsule is even further complicated as soon as it is located outside of the homogeneity volume of the non-uniform basic magnetic field. An additional problem is that the strong and rapidly changing gradient fields that are used for magnetic resonance imaging alter the position of the endoscopy capsule in an unforeseeable manner. Furthermore, it applies that the permanent magnet dipole in the endoscopy capsule locally interferes with the homogeneity of the external basic magnetic field (and thus the magnetic resonance images).

The combined magnetic resonance/magnetically guided endoscopy capsule system described in WO 2009/016207 A1 consequently does not enable a navigation and magnetic resonance imaging to be allowed simultaneously. This means that the navigation of the endoscopy capsule is deactivated if magnetic resonance imaging is specifically required, and the basic magnetic field is deactivated during the navigation of the endoscopy capsule. Alternatively, it has been proposed to connect the capsule with a catheter-like tube that leads out of the hollow organ, such that the permanently magnetic dipole of the endoscopy capsule can be removed from said endoscopy capsule in order to enable magnetic resonance imaging.

Consequently, no solution has been known as of yet to reasonably integrate a magnetically navigable endoscopy capsule into magnetic resonance systems, since the basic compatibility has been in question. It would also be generally desirable to reduce the costs and the spatial requirements for a system with a magnetically guided endoscopy capsule.

SUMMARY

An object of the invention is to provide an endoscopy capsule and an examination and/or treatment system with such an endoscopy capsule so that the design requirements are reduced (in particular in the region of the magnetic field generation device) and magnetic resonance compatibility is provided.

To achieve this object, an endoscopy capsule of the aforementioned type according to the invention has a magnetic field of the magnetic element that can be varied with external control.

In accordance with the present invention, the navigation (thus the translation movement and/or rotation of the endoscopy capsule) is not implemented by varying an external magnetic field (in particular with regard to its direction and/or its gradient), which has a significant effort associated therewith. Instead, at least one magnetic element of the endoscopy capsule is designed so that it can itself be adjusted, such that the local magnetic field in the endoscopy capsule is varied and navigation is thereby enabled. The magnetic element is preferably realized as a coil having at least one winding, which coil can be fed with current depending on an external signal. Such a coil can develop its magnetic field depending on the current and can even be switched to be field-free without an applied current. For three orthogonal spatial directions, it is also advantageous for at least one such magnetic element (in particular thus at least one coil) to be provided to generate a magnetic field in each spatial direction.

The present invention thus enables the use of “inflexible” external magnetic fields (in particular static magnetic fields or magnetic fields having a fixed direction) in order to assist navigation of the endoscopy capsule. In particular, the external magnetic field can consequently be the basic magnetic field of a magnetic resonance device so that not only is an endoscopy capsule compatible with a magnetic resonance device achieved (which is discussed in further detail in the following), but also it is no longer necessary to provide an additional magnetic field generation device, much less one that is compatible with magnetic resonance devices, in particular if the local magnetic field of the magnetic elements can be deactivated entirely (as with a coil). A better acceptance and faster spread of such endoscopy capsules is promoted in this way. However, the costs and the spatial requirements for the examination and treatment device according to the invention are reduced overall, in particular given integration into an existing magnetic resonance device. Even if a dedicated magnetic field generation device is used, this can be designed more simply and cost-effectively because (as will be described in more detail in the following) a fixed, static magnetic field is already sufficient in order to enable a navigation of the endoscopy capsule.

The present invention is thereby based on the following considerations. The force F that is exerted on a magnetic dipole m in an external magnetic field B is

{right arrow over (F)}=grad({right arrow over (m)}·{right arrow over (B)}).

Bx=By=0 applies in a homogeneous and uniform magnetic field, such that only the component Bz along the z-axis is not equal to 0. It follows that:

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