When, usualy a joke or another comment (but could also apply to a film or play etc), is either not appreciated, said when not appropriate or just plain not funny and get's either a cold response or no response at all. Similar to a lead balloon. It can be described as "Going down like a cup of cold sick".

When George told his joke, about The Englishman, the Irishman and the Scotsman, in which the Irishman appears stupid, at an Irish social club, it went down like a cup of cold sick.