Modeling of the different conformations of PRKACA (show PRKACA Antibodies)-DNAJB1 Chimeric Kinase revealed no obvious steric interactions of the J-domain with the rest of the RIIbeta (show PRKAR2B Antibodies) holoenzyme.

Data show that DnaJ (Hsp40) homolog (show DNAJB4 Antibodies), subfamily B (show CYP Antibodies), member 1 (DNAJB1) is a transcriptional target of forkhead box protein E3 (FOXE3 (show FOXE3 Antibodies)) in a pathway that is crucial for the development of the anterior segment of the eye.

These studies demonstrate an important role for cellular chaperone Hsp40/DnaJB1 in influenza A virus life cycle by assisting nuclear trafficking of viral ribonucleoproteins.

DNAJB1-PRKACA (show PRKACA Antibodies) was evaluated as a key driver of fibrolamellar carcinoma and as a candidate therapeutic target

siRNA experiments confirmed that a reduction in Hsp27 (show HSPB1 Antibodies) or Hsp40 rescued CFTR (show CFTR Antibodies) in the DeltaF508 mutant, but the rescue was not additive or synergistic with C4 + 18 treatment, indicating these correctors shared a common pathway for rescue

study provides a new molecular mechanism to regulate EGFR (show EGFR Antibodies) signaling through modulation of MIG6 (show ERRFI1 Antibodies) by DNAJB1 as a negative regulator.

Additional studies established that the increased toxicity upon mutating UbS2 stems from disrupting the autoprotective role that pathogenic ataxin-3 (show ATXN3 Antibodies) has against itself, which depends on the co-chaperone, DnaJ-1. Our data reveal a previously unrecognized balance between pathogenic and potentially therapeutic properties of the ataxin-3 (show ATXN3 Antibodies)-Rad23 interaction; they highlight this interaction as critical for the toxicity of the S

Generation of the Dnajb1-Prkaca (show PRKACA Antibodies) fusion gene in wild-type mice to be sufficient to initiate formation of tumors that have many features of human fibrolamellar hepatocellular carcinonma.

a biochemical link between Hsp40 expression and Abeta (show APP Antibodies)(42) proteostasis that is cell specific

Hsc70, Hdj1 and Hdj2 interact with soluble and fibrillar alpha-synuclein

Hsp40, which was constitutively expressed in postmeiotic spermatogenic cells in testis, was integrated into spermatozoa as two components, that is, sperm head and tail of rodent spermatozoa.

HSP-40 expression was detected after 2 h of heat stress

a role for Hsp40 crosstalk with CSPalpha in neuroprotection.

This is a paper that uses purification techiques to find the following: Hsc40 (show DNAJB5 Antibodies), a new member of the hsp40 family, exhibits similar expression profile to that of hsc70 (show HSPA8 Antibodies) in mammalian cells.

DnaJ (Hsp40) Homolog, Subfamily B, Member 1 (DNAJB1) Antigen Profile

Protein Summary

Probably involved in mitochondrial protein import. Is also required for efficient translocation of pre-pro-alpha-factor. Involved in heme regulation of HAP1, as a component of the high- molecular-weight (HMC) complex.