{"symbol":"TNFRSF1B","synonyms":["TNFR1B","TNFR2","TNF-R-II","P75TNFR","TNF-R75","CD120B","TBPII","TNFR80","TNFBR"],"name":"tumor necrosis factor receptor superfamily, member 1B","description":"The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":7133,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/7133","proteins":[{"symbol":"TNR1B_HUMAN","href":"/api/1.0/protein/TNR1B_HUMAN"}],"hgncRootFamilies":[{"name":"Tumor necrosis factor receptor superfamily (TNFRSF)","href":"/api/1.0/gene_family/Tumor+necrosis+factor+receptor+superfamily+%28TNFRSF%29"},{"name":"CD molecules (CD)","href":"/api/1.0/gene_family/CD+molecules+%28CD%29"}]}