Dibenzyline

CLINICAL PHARMACOLOGY

Dibenzyline (phenoxybenzamine hydrochloride) is a long-acting, adrenergic,
alpha-receptor- blocking agent, which can produce and maintain "chemical
sympathectomy" by oral administration. It increases blood flow to the skin,
mucosa and abdominalviscera, and lowers both supine and erect blood pressures.
It has no effect on the parasympathetic system.

Twenty to 30 percent of orally administered phenoxybenzamine appears to be
absorbed in the active form.1

The half-life of orally administered phenoxybenzamine hydrochloride is not
known; however, the half-life of intravenously administered drug is approximately
24 hours. Demonstrable effects with intravenous administration persist for at
least 3 to 4 days, and the effects of daily administration are cumulative for
nearly a week.1