Multidrug resistance-associated protein 9 is a protein that in humans is encoded by the ABCC12 gene. This gene is a member of the superfamily of ATP-binding cassette (ABC) transporters and the encoded protein contains two ATP-binding domains and 12 transmembrane regions. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies: ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White. This gene is a member of the MRP subfamily which is involved in multi-drug resistance. This gene and another subfamily member are arranged head-to-tail on chromosome 16q12.1. Increased expression of this gene is associated with breast cancer.

Catalog #

M4688-39A

Applications

Suitable for use in Western Blot, Immunohistochemistry and Immunocytochemistry. Other applications not tested.

Recommended Dilutions

Western Blot: 1:20-1:50

Immunohistochemistry (Acetone fixed frozen): 1:20, followed by incubation with RbxRt IgG and a monoclonal rat APAAP complex. Alternatively after incubation with M4688-39A and washing, slides can be incubated with RbxRt IgG (Biotin) and streptavidin conjugated to HRP.

May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Clone Type

Monoclonal

Isotype

IgG

Clone No

M9II-3

Host

Rat

Source

Human

Concentration

Not determined

Form

Supplied as a liquid in 0.7% BSA, 0.1% sodium azide.

Purity

Supernatant

Immunogen

Bacterial fusion protein of human MRP9 corresponding to aa690-734.

Specificity

Recognizes an internal epitope of human MRP9 at ~150kD.

Important Note

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.