Courses

Choosing a course is one of the most important decisions you'll ever make! View our courses and see what our students and lecturers have to say about the courses you are interested in at the links below.

About NUI Galway

Since 1845, NUI Galway has been sharing the highest quality teaching and research with Ireland and the world. Find out what makes our University so special – from our distinguished history to the latest news and campus developments.

Contact Details

Biography

My current position is as a Personal Professor in the Department of Pharmacology and Therapeutics, NUI, Galway. I have spent over 30 years involved in pharmacological and toxicological research, 8 of which have been in industry.

Research Interests

My research has centred on preclinical animal models of depression, most particularly investigating the olfactory bulbectomized and whether this myriad of changes associated with this model can be attenuated by chronic treatment with antidepressants, both established and novel treatments. This research has demonstrated how valuable the integrated approach can be in ascertaining interactions between behavioural, physiological, neurochemical and immune changes. A similar approach has been taken with other animal models under my direction, such as the Forced Swim Test and lipopolysaccharide models. This research has resulted in over 100 peer-reviewed publications.

'Consequences of Oral Gavage during Gestation and Lactation on Rat Dams and the Neurodevelopment and Behavior of Their Offspring'
McDonnell-Dowling, K,Kleefeld, S,Kelly, JP (2017) 'Consequences of Oral Gavage during Gestation and Lactation on Rat Dams and the Neurodevelopment and Behavior of Their Offspring'. Journal Of The American Association For Laboratory Animal Science, 56 :79-83 [Details]

'An investigation of whether there are sex differences in certain behavioural and neurochemical parameters in the rat'
Simpson, J. and Kelly, J.P. (2012) 'An investigation of whether there are sex differences in certain behavioural and neurochemical parameters in the rat'. Behavioural Brain Research, [Details]

'An investigation of the value of the Tetrahymena pyriformis as a test organism for assessing the acute toxicity of antidepressants'
Uma, S,Kelly, JP,Rajasekaran, SK (2008) 'An investigation of the value of the Tetrahymena pyriformis as a test organism for assessing the acute toxicity of antidepressants'. Biomedical Research-India, 19 :37-40 [Details]

'Effects of Gamma Irradiation and Pasteurization on the Nutritive Composition of Commercially Available Animal Diets'
Caulfield, CD,Cassidy, JP,Kelly, JP (2008) 'Effects of Gamma Irradiation and Pasteurization on the Nutritive Composition of Commercially Available Animal Diets'. Journal Of The American Association For Laboratory Animal Science, 47 :61-66 [ARAN Link] [Details]

'Development of a home cage locomotor tracking system capable of detecting the stimulant and sedative properties of drugs in rats'
Dunne, F., O'Halloran, A. and Kelly, J.P. (2007) 'Development of a home cage locomotor tracking system capable of detecting the stimulant and sedative properties of drugs in rats'. Prog. Neuropsychopharmacol. Biol. Psychiatry, 31 :1456-1463 [Details]

'A review of the relevance and validity of olfactory bulbectomy as a model of depression'
Harkin, A ., Kelly, J. P. and Leonard, B. E. (2003) 'A review of the relevance and validity of olfactory bulbectomy as a model of depression'. Clinical Neuroscience Research, 3 :253-262 [Details]

'Inhibition of constitutive nitric oxide production increases the severity of lipopolysaccharide-induced sickness behaviour: A role for TNF-alpha'
Connor, TJ,O'Sullivan, J,Nolan, Y,Kelly, JP (2002) 'Inhibition of constitutive nitric oxide production increases the severity of lipopolysaccharide-induced sickness behaviour: A role for TNF-alpha'. Neuroimmunomodulation, 10 :367-378 [DOI] [Details]

(2002)

'Reduction in preference for saccharin by repeated unpredictable stress in mice and its prevention by imipramine'
Harkin, A,Houlihan, DD,Kelly, JP (2002) 'Reduction in preference for saccharin by repeated unpredictable stress in mice and its prevention by imipramine'. Journal Of Psychopharmacology, 16 :115-123 [Details]

'The toxicity profile of a single dose of paroxetine: An alternative approach to acute toxicity testing in the rat'
Ryan, PM,Kelly, JP,Chambers, PL,Leonard, BE (2001) 'The toxicity profile of a single dose of paroxetine: An alternative approach to acute toxicity testing in the rat'. Pharmacology & Toxicology, 88 :59-66 [Details]

'An assessment of the acute effects of the serotonin releasers methylenedioxymethamphetamine, methylenedioxyamphetamine and fenfluramine on immunity in rats'
Connor, TJ,Kelly, JP,Leonard, BE (2000) 'An assessment of the acute effects of the serotonin releasers methylenedioxymethamphetamine, methylenedioxyamphetamine and fenfluramine on immunity in rats'. Immunopharmacology, 46 :223-235 [Details]

'Olfactory bulbectomy provokes a suppression of interleukin-1 beta and tumour necrosis factor-alpha production in response to an in vivo challenge with lipopolysaccharide: Effect of chronic desipramine treatment'
Connor, TJ,Harkin, A,Kelly, JP,Leonard, BE (2000) 'Olfactory bulbectomy provokes a suppression of interleukin-1 beta and tumour necrosis factor-alpha production in response to an in vivo challenge with lipopolysaccharide: Effect of chronic desipramine treatment'. Neuroimmunomodulation, 7 :27-35 [Details]

'Effects of reboxetine and sertraline treatments alone and in combination on the binding properties of cortical NMDA and beta 1-adrenergic receptors in an animal model of depression'
Harkin, A,Nally, R,Kelly, JP,Leonard, BE (2000) 'Effects of reboxetine and sertraline treatments alone and in combination on the binding properties of cortical NMDA and beta 1-adrenergic receptors in an animal model of depression'. Journal Of Neural Transmission, 107 :1213-1227 [Details]

'Differential effect of a single high dose of the tricyclic antidepressant imipramine on interleukin-1 beta and tumor necrosis factor-alpha secretion following an in vivo lipopolysaccharide challenge in rats'
Dredge, K,Connor, TJ,Kelly, JP,Leonard, BE (1999) 'Differential effect of a single high dose of the tricyclic antidepressant imipramine on interleukin-1 beta and tumor necrosis factor-alpha secretion following an in vivo lipopolysaccharide challenge in rats'. International Journal Of Immunopharmacology, 21 :663-673 [Details]

'Comparative effects of various antidepressant drugs and the immunosuppressant dexamethasone on the T-lymphocyte proliferative response in vitro'
Dredge, K,Connor, TJ,Kelly, JP,Leonard, BF (1999) 'Comparative effects of various antidepressant drugs and the immunosuppressant dexamethasone on the T-lymphocyte proliferative response in vitro'. Medical Science Research, 27 :773-774 [Details]

(1999)

'Activity and onset of action of reboxetine and effect of combination with sertraline in an animal model of depression'
Harkin, A,Kelly, JP,McNamara, M,Connor, TJ,Dredge, K,Redmond, A,Leonard, BE (1999) 'Activity and onset of action of reboxetine and effect of combination with sertraline in an animal model of depression'. European Journal Of Pharmacology, 364 :123-132 [Details]

(1999)

'An investigation of the antidepressant properties of lofepramine and its desmethylated metabolites in the forced swim and olfactory bulbectomized rat models of depression'
Kelly, JP,Leonard, BE (1999) 'An investigation of the antidepressant properties of lofepramine and its desmethylated metabolites in the forced swim and olfactory bulbectomized rat models of depression'. European Neuropsychopharmacology, 9 :101-105 [Details]

'Effect of single dose of imipramine on some immunotoxicological parameters in the rat'
Dredge, K,Kelly, JP,Leonard, BE (1998) 'Effect of single dose of imipramine on some immunotoxicological parameters in the rat'. Medical Science Research, 26 :789-792 [Details]

'The effects of the 5-HT1A agonist flesinoxan, in three paradigms for assessing antidepressant potential in the rat'
Cryan, JF,Redmond, AM,Kelly, JP,Leonard, BE (1997) 'The effects of the 5-HT1A agonist flesinoxan, in three paradigms for assessing antidepressant potential in the rat'. European Neuropsychopharmacology, 7 :109-114 [Details]

'An appraisal of the pharmacological and toxicological effects of a single oral administration of 3,4-methylenedioxymethamphetamine (MDMA) in the rat'
DeSouza, I,Kelly, JP,Harkin, AJ,Leonard, BE (1997) 'An appraisal of the pharmacological and toxicological effects of a single oral administration of 3,4-methylenedioxymethamphetamine (MDMA) in the rat'. Pharmacology & Toxicology, 80 :207-210 [Details]

'Some behavioural and neurochemical effects of ipsapirone in two rodent models of depression'
McNamara, MG,Kelly, JP,Leonard, BE (1996) 'Some behavioural and neurochemical effects of ipsapirone in two rodent models of depression'. Journal Of Psychopharmacology, 10 :126-133 [Details]

'EFFECT OF CHRONIC ANTIDEPRESSANT TREATMENT FOLLOWING ACUTE ADMINISTRATION OF THE NEUROTOXIN TRIMETHYLTIN IN THE RAT'
REDROBE, JP,KELLY, JP,CHAMBERS, PL,LEONARD, BE (1995) 'EFFECT OF CHRONIC ANTIDEPRESSANT TREATMENT FOLLOWING ACUTE ADMINISTRATION OF THE NEUROTOXIN TRIMETHYLTIN IN THE RAT'. Medical Science Research, 23 :407-408 [Details]

(1995)

'EFFECT OF CHRONIC ANTIDEPRESSANT ADMINISTRATION ON THE CONDITIONED TASTE-AVERSION TO 8-OHDPAT IN THE OLFACTORY BULBECTOMISED RAT MODEL OF DEPRESSION'
REDMOND, AM,KELLY, JP,LEONARD, BE (1995) 'EFFECT OF CHRONIC ANTIDEPRESSANT ADMINISTRATION ON THE CONDITIONED TASTE-AVERSION TO 8-OHDPAT IN THE OLFACTORY BULBECTOMISED RAT MODEL OF DEPRESSION'. Medical Science Research, 23 :487-488 [Details]

(1995)

'The influence of route of administration on the diabetogenic effects of streptozotocin in the rat'
MacSweeney, CP,Kelly, JP,Leonard, BE (1995) 'The influence of route of administration on the diabetogenic effects of streptozotocin in the rat'. Medical Science Research, 23 :811-812 [Details]

'Is the state of leucocyte adhesiveness/aggregation an immune marker of stress in the olfactory bulbectomized rat?'
Song, C., Kelly, J. and Leonard, B.E. (1993) 'Is the state of leucocyte adhesiveness/aggregation an immune marker of stress in the olfactory bulbectomized rat?'. Stress Medicine, 9 :255-258 [Details]

An investigation of the effects of 8-hydroxy-2-(di-n-propylamino)-tetrlin (8-OH-DPAT), on behavioural parameters in rats treated acutely and chronically with metyrapone
Brehony, F,Kelly, JP,Leonard, BE (1996) IRISH JOURNAL OF MEDICAL SCIENCE An investigation of the effects of 8-hydroxy-2-(di-n-propylamino)-tetrlin (8-OH-DPAT), on behavioural parameters in rats treated acutely and chronically with metyrapone , pp.311-311 [Details]

An investigation of the behavioural and physiological effects of acute and chronic administration of metyrapone, challenged with (+/-)3,4-methylene-dioxymethamphetamine
Brehony, F,Kelly, JP,Leonard, BE (1996) IRISH JOURNAL OF MEDICAL SCIENCE An investigation of the behavioural and physiological effects of acute and chronic administration of metyrapone, challenged with (+/-)3,4-methylene-dioxymethamphetamine , pp.312-312 [Details]

(1996)

An investigation of the effects of 8-hydroxy-2-(di-n-propylamino)-tetralin (8-OH-DPAT), on behavioural parameters in rats treated acutely and chronically with metyrapone
Brehony, F,Kelly, JP,Leonard, BE (1996) IRISH JOURNAL OF MEDICAL SCIENCE An investigation of the effects of 8-hydroxy-2-(di-n-propylamino)-tetralin (8-OH-DPAT), on behavioural parameters in rats treated acutely and chronically with metyrapone , pp.307-307 [Details]

Other Journals

Year

Publication

(2011)

'Cathinone derivatives: a review of their chemistry, pharmacology and toxicology'
Kelly, J.P. (2011) 'Cathinone derivatives: a review of their chemistry, pharmacology and toxicology' Drug Testing and Analysis, 3 :439-453. [Details]

(1997)

'Effect of chronic rafoxanide administration on behavioural and physiological parameters in the rat'
Nsimba, S.E.D., Kelly, J.P. and Leonard, B.E. (1997) 'Effect of chronic rafoxanide administration on behavioural and physiological parameters in the rat' Indian Journal of Pharmacology, 29 :289-295. [Details]

(1997)

'Effect of acute and chronic haloperidol administration and apomorphine challenge on the behavioural parameters in rats'
Nsimba, S.E.D., Kelly, J.P. and Leonard, B.E. (1997) 'Effect of acute and chronic haloperidol administration and apomorphine challenge on the behavioural parameters in rats' Indian Journal of Pharmacology, 29 :15-19. [Details]

(1997)

'The interaction between chlorpromazine and apomorphine on temperature in the rat'
Nsimba, S.E.D., Kelly, J.P. and Leonard, B.E. (1997) 'The interaction between chlorpromazine and apomorphine on temperature in the rat' Journal of Serotonin Research, 3 :161-167. [Details]

'Effect of paroxetine and fluvoxamine on behavioural changes in a number of paradigms in the olfactory bulbectomized rat model of depression'
Redmond, A.M., Kelly, J.P. and Leonard, B.E. (1994) 'Effect of paroxetine and fluvoxamine on behavioural changes in a number of paradigms in the olfactory bulbectomized rat model of depression' Journal of Serotonin Research, 3 :199-205. [Details]

Abstract

Year

Publication

(2012)

Exposure to open-field testing induces light-dependent reversal of the circadian rhythmicity of home cage locomotor activity in rats. Presented at the meeting of the Biomedical Sciences Section of the Royal Academy of Medicine in Ireland, Galway.
Bree D, O'Mahony C, Morris B, Broom DC, Kelly JP, Roche M, Finn DP (2012) Exposure to open-field testing induces light-dependent reversal of the circadian rhythmicity of home cage locomotor activity in rats. Presented at the meeting of the Biomedical Sciences Section of the Royal Academy of Medicine in Ireland, Galway. Abstract [Details]

(2011)

MATERNAL ANTIDEPRESSANT EXPOSURE AND CNS DEVELOPMENT IN THE RAT OFFSPRING.
Kelly, JP,O'Brien, S (2011) MATERNAL ANTIDEPRESSANT EXPOSURE AND CNS DEVELOPMENT IN THE RAT OFFSPRING. Abstract [Details]

(2011)

CONSEQUENCES OF IN UTERO EXPOSURE TO FLUOXETINE ON ADULT BEHAVIOUR IN THE RAT.
O'Brien, S,Kelly, JP (2011) CONSEQUENCES OF IN UTERO EXPOSURE TO FLUOXETINE ON ADULT BEHAVIOUR IN THE RAT. Abstract [Details]

(2011)

Consequences of in utero methamphetamine exposure on behaviour in the adult rat.
O'Brien, S,Campadieu, N,Higgins, D,Kelly, JP (2011) Consequences of in utero methamphetamine exposure on behaviour in the adult rat. Abstract [Details]

(2010)

EFFECTS OF IN UTERO ANTIDEPRESSANT ADMINISTRATION ON ADULT BEHAVIOUR IN THE RAT.
O'Brien, S,Kelly, JP (2010) EFFECTS OF IN UTERO ANTIDEPRESSANT ADMINISTRATION ON ADULT BEHAVIOUR IN THE RAT. Abstract [Details]

The role of the endocannabinoid system in the right basolateral amygdala in conditioned fear and associated analgesia in rats. Irish Neuroscience Group Meeting.
O'Connor E, Roche M, Diskin C, Kelly JP, Finn DP (2005) The role of the endocannabinoid system in the right basolateral amygdala in conditioned fear and associated analgesia in rats. Irish Neuroscience Group Meeting. Offaly, Ireland: Abstract [Details]

Evidence for a critical role of body temperature in the modulation of MDMA by drugs of abuse.
O'Loinsigh, E,Kelly, JP,O'Boyle, KM (2001) Evidence for a critical role of body temperature in the modulation of MDMA by drugs of abuse. Abstract [Details]

(2000)

Co-administration of D-amphetamine alters the acute and long-term effects of 3,4-methylene-dioxymethamphetamine in rats.
O'Loinsigh, ED,Kelly, JP,O'Boyle, KM (2000) Co-administration of D-amphetamine alters the acute and long-term effects of 3,4-methylene-dioxymethamphetamine in rats. Abstract [Details]

An investigation of the antidepressant properties of 8-OH-DPAT and ipsapirone in rats.
McNamara, MG,Kelly, JP,Leonard, BE (1996) An investigation of the antidepressant properties of 8-OH-DPAT and ipsapirone in rats. Abstract [Details]

THE EFFECT OF TIANEPTINE ON THE OLFACTORY BULBECTOMIZED (OB) RAT MODEL OF DEPRESSION.
KELLY, JP,LEONARD, BE (1990) THE EFFECT OF TIANEPTINE ON THE OLFACTORY BULBECTOMIZED (OB) RAT MODEL OF DEPRESSION. Abstract [Details]

Effect of a cyclodextrin-lofepramine complex on the motility of Tetrahymena pyriformis.
Darcy, P,Kelly, JP,Leonard, BE,Henry, JA (2002) Effect of a cyclodextrin-lofepramine complex on the motility of Tetrahymena pyriformis. Meeting [Details]

Note

Year

Publication

(1995)

N-G-NITRO-L-ARGININE METHYL-ESTER PROTECTS AGAINST LIPID-PEROXIDATION IN THE GERBIL FOLLOWING CEREBRAL-ISCHEMIA.
CALDWELL, M,ONEILL, M,EARLEY, B,KELLY, JP,LEONARD, BE (1995) N-G-NITRO-L-ARGININE METHYL-ESTER PROTECTS AGAINST LIPID-PEROXIDATION IN THE GERBIL FOLLOWING CEREBRAL-ISCHEMIA. Note [Details]

Reviews

Year

Publication

(2015)

Sources of variation in the design of preclinical studies assessing the effects of amphetamine-type stimulants in pregnancy and lactation.
McDonnell-Dowling, K,Kelly, JP (2015) Sources of variation in the design of preclinical studies assessing the effects of amphetamine-type stimulants in pregnancy and lactation. Reviews [DOI] [Details]

(2012)

An investigation of whether there are sex differences in certain behavioural and neurochemical parameters in the rat.
Simpson, J,Kelly, JP (2012) An investigation of whether there are sex differences in certain behavioural and neurochemical parameters in the rat. Reviews [DOI] [Details]

(2012)

Effect of early life housing manipulation on baseline and drug-induced behavioural responses on neurochemistry in the male rat.
Simpson, J,Bree, D,Kelly, JP (2012) Effect of early life housing manipulation on baseline and drug-induced behavioural responses on neurochemistry in the male rat. Reviews [DOI] [Details]

Development of a home cage locomotor tracking system capable of detecting the stimulant and sedative properties of drugs in rats.
Dunne, F,O'Halloran, A,Kelly, JP (2007) Development of a home cage locomotor tracking system capable of detecting the stimulant and sedative properties of drugs in rats. Reviews [DOI] [Details]

(2003)

A review of the relevance and validity of olfactory bulbectomy as a model of depression.
Harkin, A,Kelly, JP,Leonard, BE (2003) A review of the relevance and validity of olfactory bulbectomy as a model of depression. Reviews [DOI] [Details]