Previous GeneCards Identifiers for CCNA1 Gene

Summaries for CCNA1 Gene

Entrez Gene Summary for CCNA1 Gene

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. The cyclin encoded by this gene was shown to be expressed in testis and brain, as well as in several leukemic cell lines, and is thought to primarily function in the control of the germline meiotic cell cycle. This cyclin binds both CDK2 and CDC2 kinases, which give two distinct kinase activities, one appearing in S phase, the other in G2, and thus regulate separate functions in cell cycle. This cyclin was found to bind to important cell cycle regulators, such as Rb family proteins, transcription factor E2F-1, and the p21 family proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for CCNA1 Gene

CCNA1 (Cyclin A1) is a Protein Coding gene.
Among its related pathways are Pathways in cancer and GPCR Pathway.
GO annotations related to this gene include protein kinase binding.
An important paralog of this gene is CCND2.

UniProtKB/Swiss-Prot for CCNA1 Gene

May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells.

Protein details for CCNA1 Gene (UniProtKB/Swiss-Prot)

Protein attributes for CCNA1 Gene

Size:

465 amino acids

Molecular mass:

52358 Da

Quaternary structure:

Interacts with the CDK2 and the CDC2 protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Does not bind CDK4 and CDK5 (in vitro). The cyclin A1-CDK2 complex interacts with transcription factor E2F-1 and RB proteins. Found in a complex with CDK2, CABLES1 and CCNE1 (By similarity). Interacts with INCA1 and KLHDC9.

neXtProt entry for CCNA1 Gene

Proteomics data for CCNA1 Gene at MOPED

Protein Expression for CCNA1 Gene

Post-translational modifications for CCNA1 Gene

Polyubiquitinated via Lys-11-linked ubiquitin by the anaphase-promoting complex (APC/C), leading to its degradation by the proteasome. Deubiquitinated and stabilized by USP37 enables entry into S phase.

Molecular function for CCNA1 Gene

UniProtKB/Swiss-Prot Function: May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells.