This work discusses the relationship of the biological aging between mole-rats and rats through a unified approach from the perspective of thermodynamics. Taking calorimetric data from some published studies of the metabolism on mole-rats and rats, it is calculated the entropy production rate. It is observed that the entropy production rate in rats decays with chronological age, and develops a kind of first order phase transition. However, the mole-rats, showed that entropy production rate did not change significantly with age and exhibits a slightly higher value as an average compared to the rats analyzed. This result can be interpreted in terms of a mole-rats exhibit a more robustness, i.e. greater plasticity than rats. Furthermore, it is shown that the entropy production rate could be consider as a physical marker of biological age and a predictor of Lifespan.

How to cite this article:L. Triana, G. Cocho, R. Mansilla, & J.M. Nieto-Villar. Entropy production as a physical marker of biological age in mole-rats. International Journal of Aging Research, 2018, 1:22. DOI: 10.28933/ijoar-2018-11-0601