To reach Charleston (municipal), Sc in this distance one would set out from Warrenton, Mo bearing 121.2° or ESE and follow the great circles arc to approach Charleston (municipal), Sc bearing 127.6&deg or SE .

Both have a humid subtropical climate (Cfa).

Charleston (municipal), Sc is in or near the subtropical dry forest biome whereas Warrenton, Mo is in or near the cool temperate moist forest biome.

The mean annual temperature is 6.8 °C (12.2°F) warmer.

Average monthly temperatures vary by 9.2 °C (16.6°F) less in Charleston (municipal), Sc. The continentality subtype is semicontinental as opposed to subcontinental.

Total annual precipitation averages 338.5 mm (13.3 in) more which is equivalent to 338.5 l/m² (8.31 US gal/ft²) or 3,385,000 l/ha (361,879 US gal/ac) more. About 1 1/3 as much.

The altitude of the sun at midday is overall 6.1° higher in Charleston (municipal), Sc than in Warrenton, Mo.