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The blower is probably running when you are accelerating, but you may not have air coming out the dash vents. If there is a vac leak in the HVAC the vent control will go back to the default setting which is defrost. You may not have enough vac to keep the blend doors on the vent setting when the engine is under load.

There's many reasons this can happen, but start simple. Fuel pump may be failing. Usually under load they can not supply the fuel the engine is demanding. (Up hill acceleration is a classic example). change the fuel filter first, if that doesn't not correct the problem, test fuel system pressure. (:

do you mean its not blowing cold air or no air.these systems when the vehicle is under a load(gas pedal pushed)they cut out the a/c compressor to supply more power and voltage to the vehicle while accelerating and then when not it actuates the compressor.

Sounds like you are losing too much vacuum under acceleration. Possibly a partially stopped up converter, or bad intake manifold gasket. Possibly a bad door actuator in the heater box also, and the loss of power would be a seperate issue.

mould in evaporator case?
some vehicles have a pollen filter(air conditioning air intake filter)not sure if your vehicle has but check if it has, may need replacing.
check plenum chamber(area under front windscreen)for leaves and debris.
then can try and spray mould killing pressure can(glen 20)air freshner in through intake air places under front windscreen with windows down air cond on full fan speed on fresh air while engine running or not depending on how long and how bad smell is.
may also pay to check for blocked air cond. drain tube, is it dripping water when running?
service centres or hire places have also got fragrance and mould killing machines you can use inside vehicle under similar conditions as above(ozoneator)

hello drk...the only time you smell this is when the engine is under a load? Does is seem to be coming from the a/c vents? Any smoke? I've never heard this complaint on the 2005 6.0 powerstroke. A strong coolant or sulphur smell is what most owners report.
Could you give a little more detail please?