Benefits

Most importantly, this facilitates Dev/prod parity, which should be a goal of all developers.

What about a CDN?

If you have to ask that question, there's actually quite a good chance you don't. Static responses aren't very different than dynamic ones, especially when using the HTTP Cache headers that DJ-Static provides.

If you're running a top-tier application, optimizing for delivery and reducing frontend load, you will want to explore using a CDN with Django-Storages.