Project description

Objectives

TAXINOMISIS has 6 main objectives:

Investigation of the causal relationship of the major pathways and factors identified in symptomatic carotid artery disease

Networks, pathways and factors identified in the various cohorts’ studies (available to TAXINOMISIS Consortium) will be explored to study disease phenotypes and disintegrate them into endotypes according to specific pathobiological mechanisms

The risk stratification tool will be developed through the integration of a computational model of plaque progression, and an agent based model of plaque progression, that encompasses also machine learning and data mining techniques

A test for determining the presence of single Nucleotide Polymorphisms (SNPs) and predicting drug response according to the individual’s own genotype, and supporting personalized (precision) medical treatment

The new risk model of carotid artery disease stratification will be evaluated in an observational multicentre clinical study involving 270 asymptomatic and 30 symptomatic patients from 6 major clinical centres of vascular surgery

A thorough cost-effectiveness analysis will be performed to compare the costs and outcomes of the application of the new risk stratification model, and the lab-on-chip device for pharmacogenetics, with the current clinical practice and recommendations

This project has received funding from theEuropean Union’s Horizon 2020 Research andInnovation Programme under grant agreement No755320