Bottom Line:
MPS-treated subjects achieved a significant increase in the number of terminal hairs within the target area (P < 0.0001) which was significantly greater than placebo (P < 0.0001).MPS use also resulted in significantly less hair shedding (P = 0.002) and higher total Self-Assessment (P = 0.006) and Quality of Life Questionnaires scores (P = 0.035).There were no reported adverse events.

fig1: Subject 42. The number of terminal and vellus hairs at baseline (left) increased significantly after 90 days of treatment (right). The 4 cm2 target area of the scalp is shown in the middle and bottom rows.

Mentions:
Among the MPS-treated subjects, there was a significant increase in the mean number of terminal hairs from 178.3 (7.8) at baseline to 235.8 (18.4) at Visit 2 (f(1,29) = 362.0, P < 0.0001) but not among placebotreated subjects from 178.2 (9.6) to 180.9 (18.8) (f(1,29) = 1.25, P = 0.273) (Table 1). Consequently, the number of terminal hairs among MPS-treated subjects was also significantly greater than placebo-treated subjects at Visit 2 (f(1,58) = 200.4, P < 0.0001) due to the greater increase among the MPS-treated subjects (MPS: D0:178.3 ± 8; D90:235.8 ± 18; placebo: D0:178.2 ± 10, D90:180.9 ± 18). Changes in the clinical appearance of two treated subjects at baseline and after 90 days of treatment are apparent in Figures 1 and 2.

fig1: Subject 42. The number of terminal and vellus hairs at baseline (left) increased significantly after 90 days of treatment (right). The 4 cm2 target area of the scalp is shown in the middle and bottom rows.

Mentions:
Among the MPS-treated subjects, there was a significant increase in the mean number of terminal hairs from 178.3 (7.8) at baseline to 235.8 (18.4) at Visit 2 (f(1,29) = 362.0, P < 0.0001) but not among placebotreated subjects from 178.2 (9.6) to 180.9 (18.8) (f(1,29) = 1.25, P = 0.273) (Table 1). Consequently, the number of terminal hairs among MPS-treated subjects was also significantly greater than placebo-treated subjects at Visit 2 (f(1,58) = 200.4, P < 0.0001) due to the greater increase among the MPS-treated subjects (MPS: D0:178.3 ± 8; D90:235.8 ± 18; placebo: D0:178.2 ± 10, D90:180.9 ± 18). Changes in the clinical appearance of two treated subjects at baseline and after 90 days of treatment are apparent in Figures 1 and 2.

Bottom Line:
MPS-treated subjects achieved a significant increase in the number of terminal hairs within the target area (P < 0.0001) which was significantly greater than placebo (P < 0.0001).MPS use also resulted in significantly less hair shedding (P = 0.002) and higher total Self-Assessment (P = 0.006) and Quality of Life Questionnaires scores (P = 0.035).There were no reported adverse events.