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39 •• when the prolactin concentration is normalized and clinical symptoms of hyperprolactinemia have resolved, monitor prolactin concentration every 6 to 12 months. 40 •• if the prolactin concentration is well controlled with dopamine agonist therapy for 2 years with significant tumor reduction, gradually taper therapy to the lowest effective dose or consider discontinuing therapy. 39 check prolactin concentration after each dose reduction. •• if the prolactin concentrations remain unchanged for 1 year at the reduced dose, dopamine agonist therapy may be discontinued. •• it is essential to monitor prolactin concentration every 6 months or annually to detect the possibility of permanent remission of pituitary disease.