Materials & Methods: This semi-experimental study was done in 2013. Samples were 37 women and men patients with multiple sclerosis which were divided to experimental (n=19) and control (n=18) groups. The experimental group participated in combined training program for 8 weeks. Fatigue and quality of life were evaluated before and after training protocol. Data were analyzed using independent and dependent T tests and MANOVA test with LSD post hoc.

Findings: 8 weeks of combined training decreased the fatigue and increased the quality of life and its subscales (physical health composite, mental health composite) significantly (p=0.001).

Conclusion: Combined training causes decreasing of fatigue and increasing of quality of life in multiple sclerosis patients