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JCAD JOURNAL OF CLINICAL AND AESTHETIC DERMATOLOGY December 2017 • Volume 10 • Number 12
O R I G I N A L R E S E A R C H
well when applied daily according to the
schedule in Table 3. The percentage of subjects
who reported improvement in one or more
of their skin attributes ranged from 84 to
97 percent. Subjects evaluated lines and
wrinkles, softness, smoothness, radiance and
brightness, and overall improvement.
Advantages of this study include high rate
of survey completion (91%) and large number
of reporting subjects (n=222). The five
products provided a comprehensive anti-aging
treatment for the face, eye, and lip areas,
which age at different rates. Products were
applied in the morning, evening, or both. It is
important to note that 90 percent of subjects
reported each of the five products absorbed
well into their skin within three minutes of
application. This observation, along with the
continuous and progressive improvement in
most parameters in the 56-day study, show
that the early absorption of products into the
skin is genuine rather than superficial, and
that the beneficial effects of the products
continue to increase despite regular cleaning
of the face.
The likelihood of recommending one or
more of these products in the future ranged
from 57 percent (Group 4) to 91 percent (Group
1). The low percentage of Group 4 is, again,
attributed to the reduced clinical performance
of the day lip cream versus the night lip cream.
Values in the remaining groups were 87
percent (Group 5), 84 percent (Group 3), and
80 percent (Group 2), respectively.
CONCLUSIONS
Although the 56-day trial included only
five subjects for each test product, the
improvements in endpoints from baseline to
the end of the study were extremely high and
achieved 95-percent confidence levels for all
test products.
Results of this study support the effectiveness
of the facial, eye, and lip creams used in this
study as anti-aging products that reduce the
appearance of both fine and coarse lines and
wrinkles, increase the moisturization of the skin,
and, in the case of the face and eye products,
decrease transepidermal water loss. The test
products showed early positive effects on the
skin test sites, and these effects were see for at
least 56 days without significant adverse effects.
We attribute these results to the integration of
the dermal delivery technology, the cross linked
hyaluronic acid, and synthetically engineered
natural collagen utilized by the test products.
REFERENCES
1. Sercombe L, Veerati T, Moheimani F, et al.
Advances and challenges of liposome assisted
drug delivery. Front Pharmacol. 2015;6:286.
2. Agarwal S, Kumari PVK. Advances in Novasome
technology - a review. Int J Appl Pharm. 2013;5:
1–4.
3. Pinsky MA, inventor. Materials and methods for
delivering antioxidants into the skin. US Patent,
filed 2010.
4. Singh A, Malviya R, Sharma PK. Novasome - a
breakthrough in pharmaceutical technology: a
review article. Adv Biol Res. 2011; 5:184–189.
5. Fischer TW, Wigger-Alberti W, Elsner P. Direct and
non-direct measurement techniques for analysis
of skin surface topography. Skin Pharmacol Appl
Skin Physiol. 1999;12(1–2):1–11.
6. Seitz JC, Spencer TS. The use of capacitive
evaporimetry to measure the effects of topical
ingredients on transepidermal water loss (TEWL)
[Abstract]. Clin Res. 1982;30:608A.
7. Leveque JL, de Rigal J. Impedance methods for
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1983;34(8):419–428.
JCAD
FIGURE 18. Percentage of subjects with an improvement in one or more skin attributes (e.g., hydration, softness,
smoothness, radiance or brightness, lines and wrinkles, overall improvement) after using the test products for four weeks
TABLE 5. Onset and duration of continued improvement in skin evaluation parameters with 5 topical test products
PARAMETER
DAY FACIAL
CREAM
NIGHT FACIAL
CREAM
EYE CREAM DAY LIP CREAM
NIGHT LIP
CREAM
Onset
SELS 15 minutes 15 minutes 15 minutes 15 minutes 15 minutes
TEWL 28 days 15 minutes 14 days – –
EC 15 minutes 15 minutes 15 minutes 15 minutes 15 minutes
Duration
SELS 56 days 56 days 56 days 56 days 56 days
TEWL 56 days 56 days 56 days – –
EC 56 days 56 days 56 days 56 days 56 days
SELS: surface evaluation of living skin; TWEL: transepidermal water loss; EC: electroconductivity