The objective of the present research was to study the effect of interference of slender amaranth (Amaranthus viridis), American black nightshade (Bidens pilosa), purple nutsedge (Cyperus rotundus) and hairy beggarticks (Solanum americanum) on height, leaf area, chlorophyll content, dry mass and macronutrients accumulation and fruits fresh mass of processing tomato. The treatments were: (a) two tomato plants + two ones of A. viridis; (b) two tomato plants + two ones of B. pilosa; (c) two tomato plants + two ones of C. rotundus; e (d) two tomato plants + two ones of S. americanum. Moreover, a weed-free check with two tomato plants was maintained. For each weed species, the effect on tomato was the same for all evaluated characteristics, independently to distance used. A. viridis and S. americanum showed higher competitive potential than B. pilosa and C. rotundus. Chlorophyll content, plant height and leaf area of tomato was not affected by weed coexistence. B. pilosa and C. rotundus did not influenced on tomato macronutrients accumulation while A. viridis and S. americanum affected differentially it in function of distance used, and A. viridis was the most competitive species. Fresh mass of tomato fruits was not reduced due to coexistence with the four weed species.