Intracerebral hemorrhage (ICH) is a devastating subtype of stroke but the role of increased intracranial pressure (ICP) in ICH is unclear - especially since most studies measure ICP in rodents tethered or under anesthesia or restraint. Thus, ICP was measured using telemetry in untethered, awake rats after ICH for 4 days. In PART 1, no pressure differences were found between the site of injury and epidural space. In PART 2, a severe ICH increased ICP for 4 days with modest reductions in cerebral perfusion pressure. In PART 3, moderate to severe ICHs were compared in different models of ICH. When ICH was induced by a collagenase infusion, ICP was increased for 2 days. However, ICP did not increase when the ICH was induced by a whole blood infusion. Lastly, increases in edema correlated with increases in ICP. These findings demonstrate ICH model differences that must be considered when evaluating therapies.

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