A unique Star Trek game for handheld systems by the creatores of Starfleet Command, Star Trek: Tactical Assault takes place entirely in the original Star Trek universe and gives players total control over authentic Star Trek ships and weaponry in tense battle encounters. Both the Federation and Klingon campaign modes feature real-time combat with branching missions and multiple outcomes. Wireless multiplayer mode allows you to test your skills and tactical maneuvers against those of your friends. Successful gameplay relies on strategic movement and effective use of a ship's weapons and shields.

On the DS edition, the game can be played entirely with the touchscreen, with a graphic digital dial arranged just like that of the show.