Fusion

STRING allows inspection of the interaction evidence for any given network. Choose any of the viewers above (disabled if not applicable in your network).

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:query proteins and first shell of interactors

white nodes:second shell of interactors

Node Content

empty nodes:proteins of unknown 3D structure

filled nodes:some 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

COS2

Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins (379 aa)

Predicted Functional Partners:

COS3

Protein involved in salt resistance; interacts with sodium-hydrogen antiporter Nha1p; member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins (379 aa)

0.990

COS4

Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins (379 aa)

0.980

COS1

Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins (381 aa)

0.980

COS8

Nuclear membrane protein, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins; regulation suggests a potential role in the unfolded protein response (381 aa)

0.924

COS7

Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies (383 aa)

0.874

COS5

Protein of unknown function, member the DUP380 subfamily of conserved, often subtelomerically-encoded proteins (383 aa)

0.872

YBL108W

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data (101 aa)

0.762

PAU16

Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions (123 aa)

0.527

MRPL11

Mitochondrial ribosomal protein of the large subunit (249 aa)

0.481

AAD3

Putative aryl-alcohol dehydrogenase; similar to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role (363 aa)

a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1

node2

node1 accession

node2 accession

node1 annotation

node2 annotation

score

AAD3

COS2

YCR107W

YBR302C

Putative aryl-alcohol dehydrogenase; similar to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role

Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins

0.418

COS1

COS2

YNL336W

YBR302C

Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins

Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins

0.980

COS1

COS3

YNL336W

YML132W

Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins

Protein involved in salt resistance; interacts with sodium-hydrogen antiporter Nha1p; member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins

0.949

COS1

COS4

YNL336W

YFL062W

Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins

Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins

0.990

COS1

COS5

YNL336W

YJR161C

Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins

Protein of unknown function, member the DUP380 subfamily of conserved, often subtelomerically-encoded proteins

0.842

COS1

COS7

YNL336W

YDL248W

Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins

Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies

0.912

COS1

COS8

YNL336W

YHL048W

Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins

Nuclear membrane protein, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins; regulation suggests a potential role in the unfolded protein response

0.915

COS2

AAD3

YBR302C

YCR107W

Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins

Putative aryl-alcohol dehydrogenase; similar to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role

0.418

COS2

COS1

YBR302C

YNL336W

Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins

Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins

0.980

COS2

COS3

YBR302C

YML132W

Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins

Protein involved in salt resistance; interacts with sodium-hydrogen antiporter Nha1p; member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins

0.990

COS2

COS4

YBR302C

YFL062W

Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins

Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins

0.980

COS2

COS5

YBR302C

YJR161C

Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins

Protein of unknown function, member the DUP380 subfamily of conserved, often subtelomerically-encoded proteins

0.872

COS2

COS7

YBR302C

YDL248W

Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins

Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies

0.874

COS2

COS8

YBR302C

YHL048W

Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins

Nuclear membrane protein, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins; regulation suggests a potential role in the unfolded protein response

0.924

COS2

MRPL11

YBR302C

YDL202W

Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins

Mitochondrial ribosomal protein of the large subunit

0.481

COS2

PAU16

YBR302C

YKL224C

Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins

Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions

0.527

COS2

YBL108W

YBR302C

YBL108W

Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data

0.762

COS3

COS1

YML132W

YNL336W

Protein involved in salt resistance; interacts with sodium-hydrogen antiporter Nha1p; member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins

Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins

0.949

COS3

COS2

YML132W

YBR302C

Protein involved in salt resistance; interacts with sodium-hydrogen antiporter Nha1p; member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins

Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins

0.990

COS3

COS4

YML132W

YFL062W

Protein involved in salt resistance; interacts with sodium-hydrogen antiporter Nha1p; member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins

Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins

0.953

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Network Stats

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Functional enrichments in your networkNote: some enrichments may be expected here (why?)

Enrichment analysis is still ongoing, please wait ...

Statistical background

For the above enrichment analysis, the following statistical background is assumed: