J.S. Petersenhttp://repub.eur.nl/ppl/1730/
List of Publicationsenhttp://repub.eur.nl/eur_signature.pnghttp://repub.eur.nl/
RePub, Erasmus University RepositoryProinsulin, GLP-1, and glucagon are associated with partial remission in children and adolescents with newly diagnosed type 1 diabeteshttp://repub.eur.nl/pub/38271/
Wed, 01 Feb 2012 00:00:01 GMT<div>A. Kaas</div><div>M.L. Max Andersen</div><div>S. Fredheim</div><div>P. Hougaard</div><div>K. Buschard</div><div>J.S. Petersen</div><div>C. de Beaufort</div><div>K.J. Robertson</div><div>L. Hansen</div><div>H.B. Mortensen</div><div>L.B. Nielsen</div><div>H.J. Aanstoot</div><div>F. Chiarelli</div><div>K. Dahl-Jørgensen</div><div>H.B. Göthner</div><div>T. Danne</div><div>P. Garandeau</div><div>S.A. Greene</div><div>R. Holl</div><div>M. Kocova</div><div>P. Martul</div><div>N. Matsuura</div><div>E.J. Schoenle</div><div>L.P. Swift</div><div>R.M. Tsou</div><div>M. Vanelli</div><div>J. Åman</div>
Objective: Proinsulin is a marker of beta-cell distress and dysfunction in type 2 diabetes and transplanted islets. Proinsulin levels are elevated in patients newly diagnosed with type 1 diabetes. Our aim was to assess the relationship between proinsulin, insulin dose-adjusted haemoglobin A1c (IDAA1C), glucagon-like peptide-1 (GLP-1), glucagon, and remission status the first year after diagnosis of type 1 diabetes. Methods: Juvenile patients (n = 275) were followed 1, 6, and 12 months after diagnosis. At each visit, partial remission was defined as IDAA1C ≤9%. The patients had a liquid meal test at the 1-, 6-, and 12-month visits, which included measurement of C-peptide, proinsulin, GLP-1, glucagon, and insulin antibodies (IA). Results: Patients in remission at 6 and 12 months had significantly higher levels of proinsulin compared to non-remitting patients (p < 0.0001, p = 0.0002). An inverse association between proinsulin and IDAA1C was found at 1 and 6 months (p = 0.0008, p = 0.0022). Proinsulin was positively associated with C-peptide (p < 0.0001) and IA (p = 0.0024, p = 0.0068, p < 0.0001) at 1, 6, and 12 months. Glucagon (p < 0.0001 and p < 0.02) as well as GLP-1 (p = 0.0001 and p = 0.002) were significantly lower in remitters than in non-remitters at 6 and 12 months. Proinsulin associated positively with GLP-1 at 1 month (p = 0.004) and negatively at 6 (p = 0.002) and 12 months (p = 0.0002). Conclusions: In type 1 diabetes, patients in partial remission have higher levels of proinsulin together with lower levels of GLP-1 and glucagon compared to patients not in remission. In new onset type 1 diabetes proinsulin level may be a sign of better residual beta-cell function. Low prevalence of GAD and IA2 antibodies in schoolchildren from a village in the southwestern section of The Netherlandshttp://repub.eur.nl/pub/60990/
Thu, 25 Oct 2001 00:00:01 GMT<div>M.R. Batstra</div><div>J.S. Petersen</div><div>G.J. Bruining</div><div>D.E. Grobbee</div><div>S.A. de Man</div><div>J.L. Molenaar</div><div>T. Dyrberg</div><div>H.J. Aanstoot</div>
Glutamic acid decarboxylase (GAD) and insulinoma antigen 2 (IA2) antibodies are increasingly used as a tool to predict type I diabetes in children and as a differential diagnostic tool to distinguish type I and type II diabetes in adults. However, the background frequency of these antibodies in the general population has not been extensively studied and may differ between countries. The current study aims to establish the frequency of GAD and IA2 antibodies in an unselected population of schoolchildren and confirm the previously reported low prevalence of islet cell antibodies (ICA) in the general Dutch population. The study population consisted of 1403 unselected schoolchildren. All children were tested for GAD antibodies, and 1085 children were analyzed for IA2 antibodies by radiobinding assay. Development of diabetes was recorded during a 7-year follow-up. Five children (0.4%) were positive for GAD antibodies, one child (0.1%) was positive for IA2 antibodies. Two children developed diabetes during follow-up, one was positive for GAD antibodies only, the second was positive for both GAD and IA2 antibodies. The frequency of GAD and IA2 antibodies in the southwestern part of The Netherlands is low. This observation is in concordance with earlier studies on ICA in Dutch schoolchildren. For future diabetes prediction and intervention trials it is important to establish the background frequencies and predictive power of antibody screening in different populations.Glutamic acid decarboxylase antibodies in screening for autoimmune diabetes: influence of comorbidity, age, and sex on specificity and threshold valueshttp://repub.eur.nl/pub/9205/
Fri, 01 Jan 1999 00:00:01 GMT<div>M.R. Batstra</div><div>A. van Driel</div><div>J.S. Petersen</div><div>C.A. van Donselaar</div><div>M.J. van Tol</div><div>G.J. Bruining</div><div>D.E. Grobbee</div><div>T. Dyrberg</div><div>H.J. Aanstoot</div>