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Founded in 1944, the mission of NSF International is to protect and improve human health and the environment worldwide. Manufacturers, regulators and consumers look to NSF International to develop public health standards and certifications that help protect food, water, health and consumer products and the environment. As an independent, accredited organization, we test, audit and certify products and systems as well as provide education, training, risk management and consulting services. Operating in more than 165 countries, NSF International is a Pan American Health Organization/World Health Organization Collaborating Center on Food Safety, Water Quality and Indoor Environment.

This list of leading biotech companies is an approximate compilation of the largest companies involved in the research and development or manufacture of products designed to improve the health and well-being of humans. It is not a complete listing but the most comprehensive available. Lumigen Inc., No. 3 on last year's list, which Crain's believes would make the list, declined to provide figures, and a reliable estimate could not be made. Crain's estimates are based on industry analyses and benchmarks, news reports and a wide range of other sources. Unless otherwise noted, information was provided by the companies. Companies with headquarters elsewhere are listed with the address and top executive of their main Detroit-area office. Actual revenue figures may vary. NA = not available.1
Plans to retire as CEO this year after a replacement is found.2
Resigned in May 2017.3
Acquired by Albertsons Cos. (Boise, Idaho) in May 2017.