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Interstitial lung disease (ILD) is a common pulmonary manifestation of systemic rheumatic diseases, including rheumatoid arthritis, scleroderma, the inflammatory myopathies, primary Sjögren syndrome, and mixed connective tissue disease. Collectively, these conditions are called connective tissue disease–associated ILD. Symptoms are nonspecific and include cough and dyspnea. ILD can be a significant cause of morbidity and mortality in this patient population, and early diagnosis is essential to help prevent progression of symptoms and decline in pulmonary function.