Climate change and extreme events are already endangering the well-being of a wide range of wildlife, fish, and plants, which are intimately tied to tribal subsistence culture and popular outdoor recreation activities. Climate change is projected to continue to have adverse impacts on the regional environment, with implications for the values, identity, heritage, cultures, and quality of life of the region’s diverse population. Adaptation and informed management, especially culturally appropriate strategies, will likely increase the resilience of the region’s natural capital.