Target Details MAPT

Tau is a heterogeneous group of proteins that range in molecular weight from 50-67 kDal. They are instrumental in the assembly of microtubules and have been associated with some disease states. In normal brain, tau is localized in the axons of the neurons, but in some neuropathological lesions, it accumulates with in the body of the neuron. Tau proteins are thought to be abnormally phosphorylated in certain disease states and are found associated with the deposits with the neuron. Tau has been immunohistochemically localized to neurofibrillary tangles of Alzheimer's disease (AD).