Alan pleads before the Massachusetts Supreme Court to allow his best friend Denny (who learns some disturbing news about the progression of his Alzheimer disease) have access to an experimental drug which could slow the progression of his Alzheimer's disease is available but not FDA approved.
Meanwhile, Jerry and Katie take on a case of a woman who used a brain-enhancing drug while taking her SATs and was disqualified from Harvard. The murderous Catherine Piper returns.

Recap

The ring-tone we hear on Catherine Piper's phone is the theme song from The Practice, the show that Boston Legal spun-off from.

Carl Sack: The only show that is brave enough to have its stars over fifty is "Bo -- ". Gee, I can't say it. It'd break the wall.

This is a reference to both Boston Legal, which is the main focus of the course case (although never explicitly stated), and the use of the show's frequent use of breaking the fourth wall.

Carl Sack: We should be able to turn on our damn TV and not have to watch scripted shows with dimwitted twentysomethings running around in suits and doctors scrubs.

This is a reference to when Boston Legal was put on hiatus to air Grey's Anatomy midseason.

Alan Shore: Next week - the Supreme Court.Denny Crane: There's a finale, Alan. They should put it on television. I'd get ratings.Alan Shore: If they promoted it. Of course, I think there's a law against promoting us.

This portrays how ABC does not advertise Boston Legal as much as their other scripted shows, and has consistently done this since the show's inception.