Augmentin ES

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Augmentin ES

To reduce the development of drug-resistant bacteria and maintain the effectiveness
of AUGMENTIN ES-600 (amoxicillin/clavulanate potassium) and other antibacterial
drugs, AUGMENTIN ES-600 should be used only to treat or prevent infections that
are proven or strongly suspected to be caused by bacteria.

DRUG DESCRIPTION

AUGMENTIN ES-600 is an oral antibacterial combination consisting of the semisynthetic
antibiotic amoxicillin and the β-lactamase inhibitor, clavulanate potassium
(the potassium salt of clavulanic acid). Amoxicillin is an analog of ampicillin,
derived from the basic penicillin nucleus, 6-aminopenicillanic acid. The amoxicillin
molecular formula is C16H19N3O5S•3H2O,
and the molecular weight is 419.46. Chemically, amoxicillin is (2S,5R,6R)6-[(R)-(-)-2-Amino-2-(p-hydroxyphenyl)acetamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic
acid trihydrate and may be represented structurally as:

Clavulanic acid is produced by the fermentation of Streptomyces clavuligerus.
It is a β-lactam structurally related to the penicillins and possesses
the ability to inactivate a wide variety of β-lactamases by blocking the
active sites of these enzymes. Clavulanic acid is particularly active against
the clinically important plasmid-mediated β-lactamases frequently responsible
for transferred drug resistance to penicillins and cephalosporins. The clavulanate
potassium molecular formula is C8H8KNO5 and
the molecular weight is 237.25. Chemically, clavulanate potassium is potassium
(Z)-(2R,5R)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]-heptane-2-carboxylate
and may be represented structurally as:

What are the precautions when taking amoxicillin clavulanate potassium (Augmentin ES)?

Before taking this product, tell your doctor or pharmacist if you are allergic to amoxicillin or clavulanic acid; or to penicillin or cephalosporin antibiotics; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.