This series presents an overview of different mechanisms, and symptoms, that will benefit from the new and different psychosocial interventions that are currently being developed and used. There is a need to give different answers to the various questions that are currently being asked in the field of psychosomatic and behavioral medicine. The targets of these interventions are limiting progression to the disease state, symptom reduction, and improving the quality of life. In addition to the importance of RCT´s, we need many phase 2 studies that show both the effectiveness and efficacy of psychosocial intervention.