Title,Content,"Cohort Acronym",Abstract,"Start Date","Estimated Current Sample Size",PI,Website,"Contact Email","Contact Phone Number","Contact Details",Funders,"Recruitment Period","Estimated current sample size (number value)","Age at recruitment (number value)","Last updated",Diseases,Types,"Participant Types",Countries,Genders,"Sample sizes",Ages,Cognitive,"Funtional rating",Anthropometric,Physical,"Biological samples",Genotyping,"Brain imaging","Brain banking",Lifestyle,Socio-economic,"Health service utilisation","Institute names","Current Sample Sizes"
"The Atherosclerosis Risk in Communities Study","The Atherosclerosis Risk in Communities Study (ARIC) is a prospective epidemiologic study conducted in four U.S. communities. ARIC is designed to investigate the etiology and natural history of atherosclerosis, the etiology of clinical atherosclerotic diseases, and variation in cardiovascular risk factors, medical care and disease by race, gender, location, and date. Since 2011 a large ancillary study, the ARIC Neurocognitive Study (ARIC-NCS) has been assessing neurocognitive status and adjudicating possible cases of dementia.
Four ARIC field centers each randomly selected and recruited a cohort sample of approximately 4,000 individuals aged 45-64 from a defined population in their community. A total of 15,792 participants received an extensive baseline examination (visit 1, 1987-1989), including medical, social, and demographic data collection. Subsequent examinations occurred in 1990-92 (visit 2), 1993-95 (visit 3), 1996-98 (visit 4), 2011-2013 (visit 5) and 2016-2017 (visit 6). Visit 7 (2018-2019) is currently in progress. Follow-up occurs annually (semi-annually since 2012) by telephone to maintain contact with participants and to assess health status of the cohort.",ARIC,"ARIC is designed to investigate the etiology and natural history of atherosclerosis, the etiology of clinical atherosclerotic diseases, and variation in cardiovascular risk factors, medical care and disease by race, gender, location, and date.",1987-1989,"5,000 to 9,999","Jacqueline Wright","http://www2.cscc.unc.edu/aric/","PI email: jacqueline.wright@nih.gov; Contact email: david_couper@unc.edu; kim_ring@unc.edu","919-962-3229; 919-962-3096","ARIC Study Coordinating Center:
PI: Dr. David Couper; Project Director: Ms. Kim Ring
Collaborative Studies Coordinating Center
Department of Biostatistics
University of North Carolina at Chapel Hill
123 W. Franklin Street, Suite 450
Chapel Hill, NC 27516","National Institutes of Health (NIH)",1987-1989,"7,400",45-64,,"Alzheimer's disease|Mild cognitive impairment (MCI)|Parkinson's disease|Type of dementia/ND not specified|Vascular dementia",,"No diagnosis",USA,,"10,000 to 19,999","40 to 59|60 to 100",,"Individual psychological","Blood pressure|Height|Hip circumference|Waist circumference|Weight",,"Cardiovascular|Hearing and vision|Musculoskeletal|Reproductive|Respiratory","Gene screening","Magnetic resonance imaging (MRI)|Positron emission tomography (PET) - amyloid",,"Alcohol|Dietary habits|Physical activity|Smoking","Education|Ethnic group|Family circumstances|Informal support|Martial status|Occupation and employment","Formal health and social care service utilisation including private care","University of North Carolina at Chapel Hill",
"The ZARAgoza DEMentia DEPression project","The ZARADEMP project (ZARAgoza DEMentia
DEPression project) was designed as a longitudinal,
community-based study to examine the incidence
of dementia and the risk factors in incident cases of
dementia. It was carried out in Zaragoza, a typical,
large city in Spain, with an important proportion
of inhabitants coming from surrounding rural
areas (12). A stratified random sample of individuals
55 years of age and older, with proportional
allocation by age and sex, drawn from the eligible
individuals (n = 157 787) in the Spanish official
census lists of 1991, was invited to participate in
the baseline examination.",ZARADEMP,"The ZARADEMP project (ZARAgoza DEMentia
DEPression project) was designed as a longitudinal,
community-based study to examine the incidence
of dementia and the risk factors in incident cases of
dementia.",1991,,"Professor Antonio Lobo","https://www.ncbi.nlm.nih.gov/pubmed/21848704","alobo@unizar.es",,"Facultad de Medicina, Departamento de Medicina, Psiquiatría,
C/ Domingo Miral s/n, 50009 Zaragoza, Spain","Fondo de Investigación Sanitaria, Instituto de Salud Carlos III, Spanish Ministry of Health",1991,"1,500",>55,,"Alzheimer's disease|Dementia (unclassified)|Mild cognitive impairment (MCI)|Parkinson's disease|Subjective memory complaints (SMC) or subjective cognitive decline (SCD)|Vascular dementia",,"At-risk diagnosis",Spain,,"0 to 4,999","40 to 59|60 to 100",,"Individual psychological","Blood pressure|Height|Weight",,,,"Magnetic resonance imaging (MRI)",,"Alcohol|Physical activity|Smoking","Education|Ethnic group|Family circumstances|Housing and accommodation|Informal support|Martial status|Occupation and employment",,,
"The Confucius Hometown Aging Project","The Confucius Hometown Aging Project (CHAP) is a longitudinal study of vascular risk factors, ageing, and health in people aged 60 years or older who live in a rural community near Qufu (hometown of Confucius), Shandong, China. The study was done by local hospital staff consisting of clinicians and nurses.",CHAP,"The Confucius Hometown Aging Project (CHAP) is a longitudinal study of vascular risk factors, ageing, and health in people aged 60 years or older who live in a rural community near Qufu (hometown of Confucius), Shandong, China.",2010-2011,"0 to 4,999","Chengxuan Qiu; Zhongrui Yan","https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3895010/","chengxuan.qiu@ki.se",,"Aging Research Center, Department of Neurobiology, Health Care Sciences and Society, Karolinska Institutet-Stockholm University, Stockholm, Sweden","Department of Science and Technology and the Department of Health of Shandong Province, the Natural Science Foundation of Shandong Province",2010-2011,850,>60,,,,"No diagnosis",China,,"0 to 4,999",,,"Individual physiological|Individual psychological","Blood pressure|Height|Waist circumference|Weight","Cardiovascular|Hearing and Vision|Musculoskeletal|Reproductive|Respiratory",Blood,,,,"Alcohol|Dietary habits|Physical activity|Smoking","Education|Ethnic group|Family circumstances|Housing and accommodation|Income and finances|Informal support|Martial status|Occupation and employment",,"Jining Medical University",
"The 1970 British Cohort Study","The 1970 British Cohort Study (BCS70) follows the lives of more than 17,000 people born in England, Scotland and Wales in a single week of 1970. Over the course of cohort members lives, the BCS70 has collected information on health, physical, educational and social development, and economic circumstances among other factors.",BCS70,"The 1970 British Cohort Study (BCS70) follows the lives of more than 17,000 people born in England, Scotland and Wales in a single week of 1970.",01/04/1970,"5,000 to 9,999","Alice Sullivan","http://www.cls.ioe.ac.uk/page.aspx?&sitesectionid=795&sitesectiontitle=Welcome+to+the+1970+British+Cohort+Study","clsfeedback@ioe.ac.uk; PI email: alice.sullivan@ucl.ac.uk","44 (0) 2076126875","Centre for Longitudinal Studies
UCL Institute of Education
20 Bedford Way
London
WC1H 0AL","Economic and Social Research Council.",01/04/1970,"9,841",0,,,,"No diagnosis","United Kingdom",,"15,000 to 19,999",,,"Individual psychological","Blood pressure|Height|Hip circumference|Waist circumference|Weight","Cardiovascular|Hearing and Vision|Musculoskeletal|Reproductive|Respiratory",Blood,,,,"Alcohol|Dietary habits|Physical activity|Smoking","Education|Ethnic group|Family circumstances|Housing and accommodation|Income and finances|Informal support|Martial status|Occupation and employment|Unpaid care","Formal health and social care service utilisation including private care","University College, London",
"Japanese Study of Aging and Retirement","JSTAR project researchers aimed to construct a world-class longitudinal dataset on middle-aged and elderly Japanese persons to enable researchers worldwide to perform scientific investigation on aging and retirement from an international perspective. Despite the rapid aging of the Japanese population, no statistical survey that could properly capture the diversity of the elderly population from various viewpoints had been carried out in Japan until recently. RIETI, Hitotsubashi University jointly launched a comprehensive survey of elderly people in 2007 to collect panel data on their lives and health, with the University of Tokyo joining from 2009 onward.
The 2009 JSTAR survey includes a follow-up survey of the respondents to the 2007 survey and an initial survey of elderly people in two additional municipalities, i.e., Tosu in Saga Prefecture and Naha in Okinawa Prefecture, whereas the 2011 JSTAR Survey includes follow-up surveys of the respondents to the 2007 and 2009 surveys plus an initial survey of elderly people in three additional municipalities, Tondabayashi, Chofu, and Hiroshima",JSTAR,"JSTAR project researchers aimed to construct a world-class longitudinal dataset on middle-aged and elderly Japanese persons to enable researchers worldwide to perform scientific investigation on aging and retirement from an international perspective.",2007-2017,,"Hidehiko Ichimura, Satoshi Shimizutani","http://www.rieti.go.jp/en/projects/jstar/index.html ","jstar@rieti.go.jp; ichimura@e.u-tokyo.ac.jp; sshimizutani@iips.org; hidehashimoto-circ@umin.ac.jp",,,"Research Institute of Economy, Trade and Industry (RIETI)",2007-2017,,">50 <75",,"Dementia (unclassified)",,"No diagnosis",Japan,,"5,000 to 9,999",,,"Individual physiological|Individual psychological","Blood pressure|Height|Weight","Cardiovascular|Hearing and Vision|Musculoskeletal|Reproductive|Respiratory",,,,,"Alcohol|Dietary habits|Physical activity|Smoking","Education|Family circumstances|Income and finances|Informal support|Martial status|Occupation and employment|Unpaid care","Formal health and social care service utilisation including private care","The Research Institute of Economy, Trade and Industry (RIETI), Hitotsubashi University and The University of Tokyo",
"1958 National Child Development Study","The National Child Development Study (NCDS) is a longitudinal study which follows the lives of 17,000 people born in England, Scotland and Wales in a single week of 1958. Also known as the 1958 Birth Cohort Study, it collects information on physical and educational development, economic circumstances, employment, family life, health behaviour, wellbeing, social participation and attitudes.
Since the birth survey in 1958, there have been nine further sweeps of all cohort members at ages 7, 11, 16, 23, 33, 42, 46, 50 and 55. In 2003 (at age 45), 9,000 cohort members also participated in a special bio-medical survey to learn more about how development, environments and lifestyles affect peoples health. CLS will carry out a new survey of the NCDS cohort at age 60 in 2018.
NCDS is part of CLOSER (Cohort & Longitudinal Studies Enhancement Resources) which aims to maximise the use, value and impact of the UK's longitudinal studies.",NCDS,"The National Child Development Study (NCDS) is a longitudinal study which follows the lives of 17,000 people born in England, Scotland and Wales in a single week of 1958.",1958,"5,000 to 9,999","Professor Alissa Goodman","http://www.cls.ioe.ac.uk/ncds","clsfeedback@ioe.ac.uk","+44 (0)20 7612 6875","Centre for Longitudinal Studies
Institute of Education
20 Bedford Way
London
WC1H 0AL","Economic and Social Research Council",1958,"9,790",0,,,,"No diagnosis","United Kingdom",,"15,000 to 19,999","0 to 9|10 to 19|20 to 39|40 to 59|60 to 100",,"Individual physiological|Individual psychological","Blood pressure|Height|Hip circumference|Waist circumference|Weight","Cardiovascular|Hearing and Vision|Musculoskeletal|Reproductive|Respiratory",Blood|Saliva,"Gene screening",,,"Alcohol|Dietary habits|Physical activity|Smoking","Education|Ethnic group|Family circumstances|Housing and accommodation|Income and finances|Informal support|Martial status|Occupation and employment|Unpaid care",,"Centre for Longitudinal Studies",
LifeGene,"LifeGene is a national collaborative project designed to build up a resource for research in all medical disciplines, enabling new and groundbreaking research on the relationships among heredity, environment and lifestyle. The study includes studying several hundred thousand Swedes with the aim of creating new tools to prevent, diagnose and treat our most common diseases. LifeGene constitutes a platform for a myriad of biomedical research projects. Researchers not only in biomedicine and biotechnology but also behavioral and social sciences may benefit from access to LifeGene. By combining a biological perspective with e-epidemiology, LifeGene opens up new possibilities for a greater understanding of the interplay between heredity, lifestyle and the environment as regards to our most common diseases.",LifeGene,"The study includes studying several hundred thousand Swedes with the aim of creating new tools to prevent, diagnose and treat our most common diseases.",,"50,000 to 99,999","Nancy Pedersen","https://www.lifegene.se/","nancy.pedersen@ki.se","+46-8-524 874 18","Director of LifeGene project and Professor in Genetic Epidemiology at the Department of Medical Epidemiology and Biostatistics, Karolinska Institutet","Swedish Research Council|Karolinska Institutet|AFA Försäkring|Ragnar and Torsten Söderberg's foundations",,"52,107",18-50,,,,"No diagnosis",Sweden,,"100,000 to 499,999","10 to 19|20 to 39|40 to 59",,,"Blood pressure|Height|Hip circumference|Waist circumference|Weight","Cardiovascular|Hearing and Vision|Musculoskeletal|Reproductive|Respiratory",Blood|Saliva,"Gene screening",,,"Alcohol|Dietary habits|Physical activity|Smoking","Education|Family circumstances|Housing and accommodation|Income and finances|Martial status|Occupation and employment","Formal health and social care service utilisation including private care","Karolinska Institutet",
"The Malaysian Health and Adolescents Longitudinal Research Team study","The MyHeART study is longitudinal cohort study of 1361 schoolchildren (13-years old) attending 15 public secondary schools from the central (Kuala Lumpur and Selangor) and northern (Perak) regions of Peninsular Malaysia. The study used a stratified sampling design to select the study participants. Data collected at baseline included socio-economic, lifestyle (e.g. smoking, physical activity assessment, fitness assessment, seven-day diet history), and environmental information, anthropometric measurements, blood pressure, handgrip strength and bone mineral density. Blood samples for fasting blood glucose and lipid profiles, full blood count, renal profile, as well as bone profile and serum vitamin D were taken. This study cohort will be followed up again when participants turn 15, 17 and lastly, after a period of ten years (around the age of 27).",MyHeART,"The MyHeART study is longitudinal cohort study of 1361 schoolchildren (13-years old) attending 15 public secondary schools from the central (Kuala Lumpur and Selangor) and northern (Perak) regions of Peninsular Malaysia",2012,,"Majid Abdul Hazreen","https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4251135/","Hazreen.abdulmajid@gmail.com",,"Centre for Population Health (CePH) and Department of Social & Preventive Medicine,
Faculty of Medicine,
University of Malaya,
50603 Kuala Lumpur,
Malaysia",,2012,,13,,,,"No diagnosis",Malaysia,,"0 to 4,999","10 to 19",,,"Blood pressure|Height|Hip circumference|Waist circumference|Weight",Musculoskeletal,Blood,,,,"Alcohol|Dietary habits|Physical activity|Smoking","Ethnic group|Family circumstances",,"University of Malaya",
"Next Steps","Recruitment Period: 2004
Sample size at start or planned sample size if still recruiting: 16,122 (15,770 households included at Sweep 1; 352 ethnic boost interviews added at Sweep 4)
Estimated current sample size: 15,629
Age at recruitment: 13-14
Abstract
Next Steps (previously known as the Longitudinal Study of Young People in England - LSYPE) is a major innovative cohort study of young people. The study began in 2004 and included all young people in Year 9, aged between 13 and 14, who attended state and independent schools in England.
Next Steps is one of the main information sources for the formation and appraisal of policies relating to young people and will continue to be so for at least the next 10 years. The baseline data will be used to monitor the progress of the cohort group, evaluate the success of policies aimed at this group and provide an evidence base for further policy development. The study brings together data from a wide range of sources and reflects the variety of influences on learning and progression.
Following the initial survey at age 13-14, the cohort members were visited every year until 2010, when they were age 19-20. Young people were interviewed along with their parents up to sweep 4 (age 17).
The most recent survey took place in 2015/16, when the cohort members were 25 years old. It maintained the strong focus on education, but the content was broadened to become a more multi-disciplinary research resource. Data was collected about cohort members' housing and family life, employment and economic circumstances, education and job training, physical and emotional health, and identity and participation. A wide range of administrative data linkage consents were collected in the domains of health, education, economics and criminal behaviour.","Next Steps","The study began in 2004 and included all young people in Year 9, aged between 13 and 14, who attended state and independent schools in England.",2004,"15,000 to 19,999","Dr Lisa Calderwood","http://www.cls.ioe.ac.uk/page.aspx?&sitesectionid=1246&sitesectiontitle=Welcome+to+the+Longitudinal+Study+of+Young+People+in+England+","l.calderwood@ucl.ac.uk","+44 (0)20 7612 6875","Centre for Longitudinal Studies","Department of Education|Economic and Social Research Council",2004,"15,629",13-14,,,,"No diagnosis","United Kingdom",,"15,000 to 19,999","10 to 19",,"Individual physiological|Individual psychological",Height|Weight,"Hearing and Vision|Reproductive",,,,,"Alcohol|Dietary habits|Physical activity|Smoking","Education|Ethnic group|Family circumstances|Housing and accommodation|Income and finances|Informal support|Martial status|Occupation and employment|Unpaid care",,"University College, London",
"Nurses’ Health Study (NHS) II","The Nurses' Health Study II (NHS II) was established by Dr. Walter Willett and colleagues in 1989 with funding from the National Institutes of Health to study oral contraceptives, diet, and lifestyle risk factors in a population younger than the original NHS cohort.
Why a new cohort of nurses?
This younger generation of nurses included women who started using oral contraceptives during adolescence and were thus maximally exposed during their early reproductive life. Several case-control studies suggesting such exposures might be associated with substantial increases in breast cancer risk provided a particularly strong justification for investment in this large cohort. Researchers also planned to collect detailed information on the types of oral contraceptives used, which was not obtained in the Nurses' Health Study.
In addition, NHS II obtained information on physical activity and diet in adolescence and early adult life.",NHSII,"The Nurses' Health Study II (NHS II) was established by Dr. Walter Willett and colleagues in 1989 with funding from the National Institutes of Health to study oral contraceptives, diet, and lifestyle risk factors in a population younger than the original NHS cohort.",1989,,"Heather Eliassen and Walter Willett","http://www.nurseshealthstudy.org/","nhs2@channing.harvard.edu; PI email: walter.willett@channing.harvard.edu; heather.eliassen@channing.harvard.edu",617-525-2279,"Nurses' Health Study II
Channing Division of Network Medicine
181 Longwood Avenue
Boston, MA 02115","National Institute of Health (NIH)|National Institute for Occupational Safety and Health (NIOSH)|Breast Cancer Foundation",1989,,25-42,,"Mild cognitive impairment (MCI)|Subjective memory complaints (SMC) or subjective cognitive decline (SCD)",,"No diagnosis",USA,,"100,000 to 499,999","20 to 39|40 to 59",,"Individual physiological|Individual psychological","Blood pressure|Height|Hip circumference|Waist circumference|Weight","Cardiovascular|Hearing and Vision|Musculoskeletal|Reproductive|Respiratory",Blood|Urine,"Gene screening",,,"Alcohol|Dietary habits|Physical activity|Smoking","Ethnic group|Housing and accommodation|Informal support|Martial status|Occupation and employment","Formal health and social care service utilisation including private care","Brigham and Womens Hospital and Harvard School of Public Health",
"Cardiovascular Health Study","The Cardiovascular Health Study (CHS) is an NHLBI-funded observational study of risk factors for cardiovascular disease in adults 65 years or older. Starting in 1989, and continuing through 1999, participants underwent annual extensive clinical examinations. Measurements included traditional risk factors such as blood pressure and lipids as well as measures of subclinical disease, including echocardiography of the heart, carotid ultrasound, and cranial magnetic-resonance imaging (MRI). At six month intervals between clinic visits, and once clinic visits ended, participants were contacted by phone to ascertain hospitalizations and health status.
Information on dementia comes from two Ancillary Studies. The CHS Cognition Study (Dr. Lewis Kuller, PI) included 3608 participants who had an MRI in 1992-94 and who were followed for dementia through 1999. A follow-up study was done at the Pittsburgh field center that included 532 participants followed through 2013 (Dr. Oscar Lopez,PI).",CHS,"The Cardiovascular Health Study (CHS) is an NHLBI-funded observational study of risk factors for cardiovascular disease in adults 65 years or older.",1989-2003,"0 to 4,999","Bruce Psaty","https://chs-nhlbi.org/","eenright@uw.edu","1 206-897-1922","Erika Enright
Collaborative Health Studies Coordinating Center
Building 29, Suite 210
University of Washington, Box 354922
6200 NE 74th Street
Seattle, WA 98115","National Heart, Lung and Blood Institute",1989-2003,300,>65,,"Alzheimer's disease|Dementia (unclassified)|Frontotemporal dementia|Lewy body disease|Mild cognitive impairment (MCI)|Motor neurone disease|Other NDs not listed|Parkinson's disease|Prion disease|Spinal muscular atrophy (SMA)|Spinocerebellar ataxia (SCA)|Vascular dementia",,"No diagnosis",USA,,"5,000 to 9,999","60 to 100",,"Individual physiological|Individual psychological","Blood pressure|Height|Hip circumference|Waist circumference|Weight","Cardiovascular|Hearing and Vision|Musculoskeletal|Reproductive|Respiratory",Blood|Urine,"Gene screening","Magnetic resonance imaging (MRI)",,"Alcohol|Dietary habits|Physical activity|Smoking","Education|Ethnic group|Family circumstances|Housing and accommodation|Income and finances|Informal support|Martial status|Occupation and employment","Formal health and social care service utilisation including private care","National Heart, Lung and Blood Institute",
"Quebec Longitudinal Study of Child Development","The main objective of QLSCD is to identify the precursors of childrens social adaptation, school adjustment, and well-being throughout their developmental trajectory. This study has information on young childrens (now young adults) health, behaviour and many other aspects of their life.",QLSCD,"The main objective of QLSCD is to identify the precursors of childrens social adaptation,school adjustment, and well-being throughout their developmental trajectory",1998,,"Bertrand Perron","http://www.iamillbe.stat.gouv.qc.ca/default_an.htm","bertrand.perron@stat.gouv.qc.ca; nancy.illick@stat.gouv.qc.ca","(514) 873-4749 postes 6132 / 6126","Direction des enquêtes longitudinales et sociales
Institut de la statistique du Québec
1200, ave McGill College, bureau 500
Montréal, Qc. H3B 4J8","Fondation Lucie et André Chagnon, Ministère de la Santé et des Services sociaux du Québec, Ministère de la Famille du Québec, Ministère de lÉducation et de lEnseignement supérieur du Québec, Institut de la statistique du Québec, Institut de recherche Robert-Sauvé en santé et en sécurité du travail, Centre hospitalier universitaire Sainte-Justine",1998,,"5 months",,,,"No diagnosis",Canada,,"0 to 4,999","0 to 9|10 to 19",,,"Blood pressure|Height|Hip circumference|Waist circumference|Weight",Cardiovascular,Blood|Other|Saliva,"Gene screening",,,"Alcohol|Dietary habits|Physical activity|Smoking","Education|Family circumstances|Housing and accommodation|Income and finances|Occupation and employment","Formal health and social care service utilisation including private care","Institut de la statistique du Québec",
"Shanghai Cohort Study on Mild Cognitive Impairment","The study is a prospective cohort study that included 400 subjects with MCI enrolled in at Huashan Hospital in Shanghai, China and a followed-up once annually for three years. The objectives are to identify individuals with MCI who convert to AD and to explore factors associated with the conversion. The observation time point is every 12 months and phone interview on 6th, 18th month. The primary endpoint was the time from diagnosis to the conversion from MCI to Probable AD Dementia. The secondary endpoints are the time to conversion from MCI to Possible AD Dementia or Probable AD Dementia, time to Conversion from MCI to All-cause Dementia, Overall survival, Changes in Neuropsychological examinations and Changes in MRI from baseline to the end of follow-up. The planned research duration was from Jan 2012 to Dec 2016.",,"Establish cohort of patients with mild cognitive impairment (MCI) in order to identify the risk factors and validation of neuropsychological tests for early detection of Alzheimer disease.",2012-2014,,"Professor Bin Zhou","http://www.omicsonline.org/open-access/shanghai-cohort-study-on-mild-cognitive-impairment-study-desig-nand-baseline-characteristics-2161-0460-1000224.php?aid=72294","zhoubin@tri-kobe.org",-3039090,"Bin Zhou
Translational Research Informatics Center
Foundation for Biomedical Research and Innovation
1-5-4 Minatojimaminamimachi, Chuo-ku, Kobe, Japan 650-0047","The Foundation of Biomedical Research and Innovation",2012-2014,,>18,,"Alzheimer's disease|Mild cognitive impairment (MCI)",,"Condition diagnosed",China|Japan,,"0 to 4,999","40 to 59|60 to 100",,"Individual physiological|Individual psychological",Height|Weight,"Cardiovascular|Hearing and Vision",Blood,"Gene screening","Magnetic resonance imaging (MRI)",,"Alcohol|Physical activity|Smoking","Education|Martial status","Formal health and social care service utilisation including private care","Foundation for Biomedical Research and Innovation|Fudan University",
"The Malaysian Cohort project","The Malaysian Cohort study was initiated in 2005 by the Malaysian government. The top-down approach to this population-based cohort study ensured the allocation of sufficient funding for the project which aimed to recruit 100 000 individuals aged 3570 years. Participants were recruited from rural and urban areas as well as from various socioeconomic groups. The main objectives of the study were to identify risk factors, to study gene-environment interaction and to discover biomarkers for the early detection of cancers and other diseases. At recruitment, a questionnaire-based interview was conducted, biophysical measurements were performed and biospecimens were collected, processed and stored. Baseline investigations included fasting blood sugar, fasting lipid profile, renal profile and full blood count. Active follow-up and reassessment started in 2013 and to date 35,000 participants have been reassessed including biospecimens.",TMC,"The main objectives of the study were to identify risk factors, to study gene-environment interaction and to discover biomarkers for the early detection of cancers and other diseases. 100 000 individuals aged 3570 years were recruited.",2005,,"Rahman Jamal","http://www.ukm.my/mycohort/ms/","managementcohort@gmail.com; rahmanj@ppukm.ukm.edu.my",,"UKM Medical Molecular Biology Institute,
Universiti Kebangsaan Malaysia,
Jalan Yaacob Latif,
Cheras,
56000 Kuala Lumpur,
Malaysia.","Ministry of Science, Technology and Innovation (MOSTI)|Ministry of Education",2005,,35-70,,"Alzheimer's disease",,"No diagnosis",Malaysia,,"100,000 to 499,999","40 to 59|60 to 100",,,"Blood pressure|Height|Hip circumference|Waist circumference|Weight",Cardiovascular|Reproductive|Respiratory,Blood|Urine,"Gene screening",,,"Alcohol|Dietary habits|Physical activity|Smoking","Education|Ethnic group|Family circumstances|Housing and accommodation|Income and finances|Martial status|Occupation and employment","Formal health and social care service utilisation including private care","Universiti Kebangsaan Malaysia",
"The West of Scotland Twenty-07 Study: Health in the Community","The West of Scotland Twenty-07 Study: 'Health in the community' was set up in 1986 in order to investigate the reasons for differences in health by socio-economic circumstances, gender, the place where people live, age, ethnic group and family type.
The basic design of the Study involved recruiting three cohorts (groups) of volunteers, each group born twenty years apart. Members of the oldest cohort were born around 1932, those in the middle cohort were born in 1952, and those in the youngest cohort were born in 1972. A total of 4,510 people agreed to take part, and have been followed for 20 years. The final wave of data collection was completed in 2008. This means that when the Study began (1987/8) participants were 15, 35 or 55 years old, and by the end of the Study (2007/8), participants were 35, 55 and 75 years old.
The data collected are extensive and include self-reported mental and physical health (including chronic conditions, medications, disabilities); physical measures; biomarkers; cognition; life circumstances (including employment, housing, family); health behaviours; beliefs, attitudes and values. The cohort is being followed up for mortality using linkage to national records. Any data on neurodegenerative disease are from self-reported health and / or death certificates.
A full description of the cohort profile is available in the following publication: Cohort Profile: West of Scotland 20-07 study: health in the community. International Journal of Epidemiology 2009;38:1215-23",Twenty-07,"The West of Scotland Twenty-07 Study: 'Health in the community' was set up in 1986 in order to investigate the reasons for differences in health by socio-economic circumstances, gender, the place where people live, age, ethnic group and family type.",1986-1987,"0 to 4,999","Anne Ellaway","http://2007study.sphsu.mrc.ac.uk/","sphsu-twenty07@glasgow.ac.uk; PI email: Anne.Ellaway@glasgow.ac.uk","0141 353 7500","MRC/CSO Social and Public Health Sciences Unit, University of Glasgow, Top floor, 200 Renfield Street, Glasgow, G2 3QB","Medical Research Council",1986-1987,2604,"15, 35, 55",,"Dementia (unclassified)",,"No diagnosis","United Kingdom",,"0 to 4,999","10 to 19|20 to 39|40 to 59|60 to 100",,,"Blood pressure|Height|Hip circumference|Waist circumference|Weight","Cardiovascular|Hearing and Vision|Musculoskeletal|Reproductive|Respiratory",Blood,"Gene screening",,,"Alcohol|Dietary habits|Physical activity|Smoking","Education|Ethnic group|Family circumstances|Housing and accommodation|Income and finances|Informal support|Martial status|Occupation and employment|Unpaid care","Formal health and social care service utilisation including private care","University of Glasgow",
"Uppsala Longitudinal Study of Adult Men","ULSAM is a unique, ongoing, longitudinal, epidemiologic study based on all available men, born between 1920 and 1924, in Uppsala County, Sweden. The men were investigated at the ages of 50, 60, 70, 77, 82 88 and 93 years. The reinvestigations in ULSAM were based on the previous investigations. Full screening and official registry data is available in our databases and more data is continuously added.
Health examination at 93 years of age was carried out between December 2013 and March 2015. To this examination 245 men have been invited. Totally 147 men (60%) participated in the investigation. Of these, 23 men were examined at the hospital and 102 were visited at home by a nurse. In addition, 22 men completed only a questionnaire. To this examination even spouses were invited. In the complete examination 43 spouses have participated and 11 completed only a questionnaire.",ULSAM,"ULSAM is a unique, ongoing, longitudinal, epidemiologic study based on all available men, born between 1920 and 1924, in Uppsala County, Sweden.",1970-1973,"0 to 4,999","Professor Martin Ingelsson","http://www.pubcare.uu.se/ulsam/Database","martin.ingelsson@pubcare.uu.se (Head of Geriatrics / Principal investigator for ULSAM); vilmantas.giedraitis@pubcare.uu.se (ICTUS coordinator / ULSAM data manager)","+46 18 471 41 07; +46 18 471 50 39",,"UK Medical Research Council|Swedish Research Council|Swedish Council for Working Life",1970-1973,147,>50,,"Alzheimer's disease|Frontotemporal dementia|Lewy body disease|Mild cognitive impairment (MCI)|Parkinson's disease|Vascular dementia",,"No diagnosis",Sweden,,"0 to 4,999","40 to 59|60 to 100",,,"Blood pressure|Height|Hip circumference|Waist circumference|Weight",Cardiovascular|Musculoskeletal|Respiratory,"Blood|Cerebral spinal fluid (CSF)|If CSF was collected is biomarker data available|Urine","Gene screening",,"Consent for brain donation","Alcohol|Dietary habits|Physical activity|Smoking","Education|Family circumstances|Housing and accommodation|Martial status|Occupation and employment","Formal health and social care service utilisation including private care","Uppsala University",
"The Victoria Longitudinal Study","The VLS is a long-term, large-scale, and multi-faceted longitudinal investigation of human aging. Incorporating biomedical approaches, leading-edge technologies, and epidemiological perspectives, the VLS evaluates and tracks actual cognitive, health, functional and lifestyle trajectories leading to outcomes that can be classified as normal, resilient, exceptional, impaired, or dementia. Our studies examine these differential brain and cognitive changes as a function of interactions among multiple biomarkers of both risk and protection. Among these dynamically interacting biomarkers are those representing selected aspects of biological, health, genetic, metabolic, vascular, lifestyle, physical fitness, cognitive activity, sex/gender, and demographic domains",VLS,"The VLS is a long-term, large-scale, and multi-faceted longitudinal investigation of human aging.",1986-present,"0 to 4,999","Dr. Roger A. Dixon","https://sites.ualberta.ca/~vlslab/index.html","vlslab@ualberta.ca; PI Email: rdixon@ualberta.ca",780-492-7602,"VLS Lab Edmonton
Department of Psychology
P-217 Biological Sciences Building
University of Alberta
Edmonton, Alberta
T6G 2E9, Canada","National Institutes of Health (National Institute on Aging)",1986-present,600,55-85,,"Mild cognitive impairment (MCI)|Subjective memory complaints (SMC) or subjective cognitive decline (SCD)",,"No diagnosis",Canada,,"0 to 4,999","40 to 59|60 to 100",,"Individual physiological|Individual psychological","Blood pressure|Height|Weight","Cardiovascular|Hearing and Vision|Musculoskeletal|Respiratory",Saliva,"Gene screening",,,"Alcohol|Dietary habits|Physical activity|Smoking","Education|Ethnic group|Family circumstances|Housing and accommodation|Informal support|Martial status|Occupation and employment",,"University of Alberta",
"Concord Health and Ageing in Men Project","The Concord Health and Ageing in Men Project (CHAMP) is one of the worlds largest and most comprehensive study of the health of older men ever conducted anywhere in the world. CHAMP involves 1705 men aged 70 years and older recruited from the community living near Concord Hospital in Sydneys inner west. Subjects were recruited during 2005 and 2006 and subjects were re-assessed after two, five and nine years. A 14 year follow-up assessment (wave 5) is planned for 2019. Clinical dementia assessment was done at baseline but not in waves 2, 3, and 4. Clinical dementia assessment will be included in wave 5.
The study is particularly concerned with cognitive impairment and dementia; falls, fractures and osteoporosis; and urinary problems.",CHAMP,"The Concord Health and Ageing in Men Project (CHAMP) is one of the worlds largest and most comprehensive study of the health of older men ever conducted anywhere in the world.",2005,,"Professor Robert Cumming","http://www.dementia.unsw.edu.au/prevention-risk-and-population-health/aust-cohort/champ.html","bobc@health.usyd.edu.au: PI email: Robert.cumming@sydney.edu.au",,"School of Public Health, University of Sydney, NSW, Australia.","National Health and Medical Research Council of Australia|Ageing and Alzheimer's Research Foundation",2005,,>70,,"Dementia (unclassified)|Mild cognitive impairment (MCI)",,"No diagnosis",Australia,,"0 to 4,999","60 to 100",,"Individual physiological|Individual psychological","Blood pressure|Height|Weight",Cardiovascular|Musculoskeletal|Reproductive,Blood,"Gene screening",,,"Alcohol|Dietary habits|Physical activity|Smoking","Education|Ethnic group|Housing and accommodation|Informal support|Martial status|Occupation and employment","Formal health and social care service utilisation including private care","University of Sydney",
"Korean Longitudinal Study of Ageing","Korea became an ageing society in 2000, as the proportion of those 65 or older reached 7% of the population. Thereafter, the country is expected to undergo a rapid ageing process. Korea was belated compared to other advanced countries in reaching the ageing society status, but it is expected to become a super-aged society around the same time as others.
Lacking in basic data on ageing, Korea is in need of a structured set of statistical data. - Institutional reform and policy-making in preparation against the aged society require systematic build-up of data that can track individuals' labor participation, income and asset status, spending patterns, retirement decisions, impact of social welfare, health, and intra-family transfer of income, among others.
The purpose of KLoSA is to create the basic data needed to devise and implement effective social, economic policies to address the trends that emerge in the process of population ageing.
The data will help identify and observe different dimensions of an aged society, build datasets that enable studies in different fields, and generate data comparable with similar panel studies in other countries (eg. U.S., Europe) that can provide the basis for policy-making and academic studies.",KLoSA,"The purpose of KLoSA is to create the basic data needed to devise and implement effective social, economic policies to address the trends that emerge in the process of population ageing",2006-present,"10,000 to 14,999","Eun Young Kim","https://survey.keis.or.kr/eng/klosa/index.jsp","jina07@keis.or.kr","+82 43-870-8246","Employment Statistics Survey Team, KEIS, 6, Taejeong-ro, Maengdong-myeon, Eumseong-gun, Chungcheongbuk-do, 27740, Republic of Korea","Korea Employment Information Service (KEIS)",2006-present,"10,000",>45,,,,"No diagnosis","South Korea",,"10,000 to 14,999","40 to 59|60 to 100",,,Height|Weight,Musculoskeletal,,,,,"Alcohol|Dietary habits|Physical activity|Smoking","Education|Family circumstances|Housing and accommodation|Income and finances|Informal support|Martial status|Occupation and employment|Unpaid care","Formal health and social care service utilisation including private care","Korea Employment Information Service (KEIS)",
EPIPorto,"The EPIPorto study is a landmark in epidemiological research in Portugal. It is a population-based cohort study, ongoing for over 15 years, with the main aim of assessing the determinants of health in the adult population of Porto. For this purpose we randomly selected 2485 persons, who have been repeatedly evaluated over time.
Participants were invited to visit the study centre to answer a questionnaire on social, demographic and behavioural characteristics, and their clinical history. Additionally, objective measurements were made, including blood tests, blood pressure, weight and height, electrocardiogram, evaluation of lung function and bone mineral density. The participants address was georeferenced, allowing the analysis of the spatial distribution of health states and events in the city. Subgroups of the cohort at the baseline evaluation were used as controls in case-control studies namely on myocardial infarction and gastric cancer.",EPIPorto,"It is a population-based cohort study, ongoing for over 15 years, with the main aim of assessing the determinants of health in the adult population of Porto.",1999-2003,,"Henrique Barros","http://ispup.up.pt/research/research-structures/cohorts/","hbarros@med.up.pt","+351 222 061 820","EPIUnit, Institute of Public Health, University of Porto, Porto, Portugal","Fundação para a Ciência e a Tecnologia (Foundation for Science and Technology)",1999-2003,,18-92,,,,,Portugal,,"0 to 4,999",,,"Individual psychological","Blood pressure|Height|Hip circumference|Waist circumference|Weight",Cardiovascular|Musculoskeletal|Reproductive|Respiratory,Blood,,,,"Alcohol|Dietary habits|Physical activity|Smoking","Education|Ethnic group|Family circumstances|Housing and accommodation|Income and finances|Informal support|Martial status|Occupation and employment|Unpaid care","Formal health and social care service utilisation including private care","ISPUP - Public Health Institute of the University of Porto",
"MemoVie Cohort Study","The MemoVie cohort study aims to investigate the living conditions or risk factors under which the normal cognitive capacities of the senior population in Luxembourg (? 65?year-old) evolve (1) to mild cognitive impairment (MCI) ? transitory non-clinical stage ? and (2) to AD. Identifying MCI and AD predictors undeniably constitutes a challenge in public health in that it would allow interventions which could protect or delay the occurrence of cognitive disorders in elderly people. In addition, the MemoVie study sets out to generate hitherto unavailable data, and a comprehensive view of the elderly population in the country.
A 1-year follow-up was included in the original design of the study. The enrolled participants have been followed-up.",,"The MemoVie cohort study aims to investigate the living conditions or risk factors under which the normal cognitive capacities of the senior population in Luxembourg (? 65?year-old) evolve (1) to mild cognitive impairment (MCI) ? transitory non-clinical stage ? and (2) to AD.",2008-2010,"0 to 4,999","Dr Magali Perquin","http://bmcpublichealth.biomedcentral.com/articles/10.1186/1471-2458-12-519","magali.perquin@lih.lu; michel.vaillant@lih.lu",,"LIH, EPHRU,
1A-1B rue Thomas Edison,
Strassen,
L-1445,
Luxembourg","Fonds National de la Recherche (FNR) of Luxembourg",2008-2010,438,"> 64",,"Alzheimer's disease|Dementia (unclassified)|Mild cognitive impairment (MCI)|Parkinson's disease|Subjective memory complaints (SMC) or subjective cognitive decline (SCD)|Vascular dementia",,"No diagnosis",Luxembourg,,"0 to 4,999","60 to 100",,"Caregiver|Individual physiological|Individual psychological",,Cardiovascular|Musculoskeletal,Blood,"Gene screening",,,"Alcohol|Physical activity|Smoking","Education|Family circumstances|Housing and accommodation|Martial status|Occupation and employment",,"Luxembourg Institute of Health (LIH)|The Epidemiological and Public Health Research Unit (EPHRU)",
"Andhra Pradesh Children And Parents Study","The Andhra Pradesh Children and Parent Study (APCAPS) is a large prospective, intergenerational cohort study in Southern India that began with the long-term follow-up of the Hyderabad Nutrition Trial (1987-1990). It is situated in 29 villages near the city of Hyderabad in Ranga Reddy district, Andhra Pradesh.
The Hyderabad Nutrition Trial evaluated the Integrated Child Development Services (ICDS) scheme, a national community outreach program, which provides a daily food supplement to pregnant women and children under 6 years of age. The trial used a controlled stepped wedge design, recruiting pregnant women from 29 villages (15 intervention  with program; 14 controls  awaiting implementation) and followed them through to childbirth.
In 2003-5, trial households were retraced and surveyed: families with at least one child born during the trial period and still alive in 2003-05 became the APCAPS prospective cohort (1815 families, 2601 index children). At this time, a first wave (W1) of data collection was carried out on index children and their mothers. The index children were then re-examined as young adults (aged 18-23 years) in 2009-10 (the second wave, W2) and then again in 2010-12 (the third wave, W3) when their siblings and parents were also examined. A socio-demographic household survey of all residents in all 29 villages was completed between 2012 and 2014.",APCAPS,"The Andhra Pradesh Children and Parent Study (APCAPS) is a large prospective, intergenerational cohort study in Southern India. Three waves of data collection have been performed including children, siblings and parents.",2003-2012,"5,000 to 9,999","Dr Sanjay Kinra","http://apcaps.lshtm.ac.uk/overview/","apcaps@iiphh.org; PI email: Sanjay.Kinra@lshtm.ac.uk; kammilisanthi@gmail.com",,,"Indian Council for Medical Research, United States Assistance for International Development, Wellcome Trust, European Commission Strategic Award, National Institute of Nutrition",2003-2012,"6,659",Nov-14,,,,"No diagnosis",India,,"5,000 to 9,999",,,"Individual physiological","Blood pressure|Height|Hip circumference|Waist circumference|Weight",Cardiovascular|Musculoskeletal|Reproductive|Respiratory,Blood|Saliva,,,,"Alcohol|Dietary habits|Physical activity|Smoking","Education|Ethnic group|Family circumstances|Housing and accommodation|Informal support|Martial status|Occupation and employment|Unpaid care","Formal health and social care service utilisation including private care","National Institute of Nutrition",
"Aspirin in Reducing Events in the Elderly","ASPREE is a double-blind, randomized, placebo-controlled primary prevention trial designed to assess whether daily active treatment of 100 mg enteric-coated aspirin will extend the duration of disability-free life in healthy participants aged 70 years and above except for Hispanic and African American minority groups in the U.S. where the minimum age of entry is 65 years.
The primary objective is to determine whether low-dose aspirin prolongs life, or life free of dementia, or life free of significant, persistent physical disability in the healthy elderly. Secondary objectives relate to the effects of low-dose aspirin on the key outcome areas of death, cardiovascular disease, dementia and cognitive decline, cancer, physical disability, depression and major bleeding episodes. Variables were collected annually through visits and for the purposes of retention telephone calls were scheduled at set points through the 7 years.",ASPREE,"ASPREE is a double-blind, randomized, placebo-controlled primary prevention trial. The primary objective is to determine whether low-dose aspirin prolongs life, or life free of dementia, or life free of significant, persistent physical disability in the healthy elderly. Variables will be collected annually for 7 years.",2011,,"Professor Anne Murray, Professor John McNeil and Ms Brenda Kirpach","http://www.aspree.org/","aspreegp@monash.edu; bkirpach@bermancenter.org
PI email: amurray@bermancenter.org; John.McNeil@monash.edu","Tel: 612-873-6905","USA:
ASPREE Project Manager, Brenda Kirpach
Berman Center for Outcomes & Clinical Research
701 Park Ave, Suite PPC4.440
Minneapolis, MN 55415

Australia:
ASPREE National Co-ordinating and Clinical Trial Centre,
Ground Floor, Burnet Building
89 Commercial Road, Melbourne 3004","USA and Australian Government",2011,,"> 65",,"Alzheimer's disease|Other NDs not listed|Vascular dementia",,"No diagnosis",Australia|USA,,"10,000 to 19,999","60 to 100",,"Individual physiological|Individual psychological","Blood pressure|Height|Waist circumference|Weight","Cardiovascular|Hearing and Vision",Blood|Urine,,"Magnetic resonance imaging (MRI)",,"Alcohol|Dietary habits|Physical activity|Smoking","Education|Ethnic group|Family circumstances|Housing and accommodation|Income and finances|Informal support|Martial status|Occupation and employment|Unpaid care","Formal health and social care service utilisation including private care","Monash University",
"Chinese Longitudinal Healthy Longevity Study","The Chinese Longitudinal Healthy Longevity Study (CLHLS) is a large-scale population-based study on health status and quality of life of the elderly in 23 provinces (out of 31 provinces) of China since 1998 with 8 waves so far. The study covers approximately 85% of the total population of China and was conducted to shed light on the determinants of human healthy longevity. The CLHLS tried to interview all consenting centenarians in the sampled counties and cities. For each centenarian interviewee, compatible nearby un-related elderly and younger participants were interviewed, including about one nonagenarian aged 90-99, one octogenarian aged 80-89, 1.5 young-old adult aged 65-79 and 0.7 middle-aged adult aged 40-64. Detailed longitudinal data on physical and mental health, cognitive function, social participation, etc. at old ages were collected from a total of 96,805 face-to-face interviews with 16,557 centenarians, 23,081 nonagenarians, 25,842 octogenarians, 19,650 younger elders aged 65-79, and 11,675 aged 35-64 in the completed 7 waves from 1998 to 2014. For the 26,701 participants who died between these seven waves, data on mortality and quality of life before death (i.e., degree/length of disability and suffering before death) were collected in interviews with a close family member of the deceased. The completed seven waves of CLHLS had collected DNA samples from 24,693 participants, including 4,849 centenarians, 5,190 nonagenarians, 5,274 octogenarians, 4,770 aged 65-79, and 4,609 aged 40-64. The 8th wave of CLHLS is ongoing and expected to be completed by the end of July 2018.",CLHLS,"The Chinese Longitudinal Healthy Longevity Study (CLHLS) is a large-scale population-based study on health status and quality of life of the elderly in 23 provinces (out of 31 provinces) of China since 1998 with 8 waves so far. A total of 96,805 participants were recurited to wave 1.",1998-2018,"50,000 to 99,999","Professor Yi Zeng","http://web5.pku.edu.cn/ageinghttps://www.icpsr.umich.edu/icpsrweb/ICPSR/studies/36692#bibcite","zengyi@nsd.pku.edu.cn; qwang@nsd.pku.edu.cn; huashuai.chen@duke.edu","China Tel: 86-10-62753692 USA Tel: 1-919-660-7554","China:
Ms. Qian Wang,
Center for Healthy Aging and Development Studies,
National School of Development
Peking University

USA:
Dr. Huashuai Chen,
Center for the Study of Aging and Human Development,
Duke University","National Natural Science Foundation of China, National Institutes of Health/National Institute on Aging, United States",1998-2018,"70,104","> 35",,"Alzheimer's disease|Dementia (unclassified)",,"No diagnosis",China,,"50,000 to 99,999","100+|20 to 39|40 to 59|60 to 100",,"Caregiver|Individual physiological|Individual psychological","Blood pressure|Height|Hip circumference|Waist circumference|Weight","Cardiovascular|Hearing and Vision|Respiratory",Blood|Saliva|Urine,"Gene screening",,,"Alcohol|Dietary habits|Physical activity|Smoking","Education|Ethnic group|Family circumstances|Housing and accommodation|Income and finances|Informal support|Martial status|Occupation and employment|Unpaid care","Formal health and social care service utilisation including private care","Duke University|Peking University",
"Einstein Aging Study","Since 1993 the EAS has used systematic recruiting methods to assemble a cohort of over 2,200 elderly individuals from the Bronx, 26% of whom are African American. The EAS sample is broadly representative of the elderly population in one of the poorest and most racially and ethnically diverse urban counties in the United States.
The EAS has developed, tested, and applied strategies designed to meet the recruitment and retention challenges that may arise when conducting research studies with older adults. In 2004, the EAS began using the Registered Voter Lists (RVL) for Bronx County for continuous recruitment efforts. Individuals of at least 70 years of age, Bronx residents, non-institutionalized and English speaking are randomly selected from updated RVL and sent a letter followed by a screening telephone call. Persons who complete the telephone screening battery and agree to participate in clinical follow-up are invited to enroll. Continuing enrollment has resulted in over 2200 participants by 2017.",EAS,"EAS has used systematic recruiting methods to assemble a cohort of over 2,200 elderly individuals from the Bronx, 26% of whom are African American. The EAS sample is broadly representative of the elderly population in one of the poorest and most racially and ethnically diverse urban counties in the United States.","1993 - present","0 to 4,999","Dr Richard Lipton and Dr. Martin Sliwinski","https://www.einstein.yu.edu/departments/neurology/clinical-research-program/eas/","mindy.katz@einstein.yu.edu
PI Email: richard.lipton@einstein.yu.edu","Tel: +1 718 430 3888","Albert Einstein College of Medicine,
Yeshiva University
Saul B. Korey Department of Neurology
1300 Morris Park Avenue Van Etten
Bronx, N.Y.
10461","National Institute of Aging (NIA)","1993 - present","2,000","> 70",,"Alzheimer's disease|Frontotemporal dementia|Lewy body disease|Mild cognitive impairment (MCI)|Parkinson's disease|Subjective memory complaints (SMC) or subjective cognitive decline (SCD)|Vascular dementia",,"No diagnosis",USA,,"0 to 4,999","60 to 100",,"Individual physiological|Individual psychological","Blood pressure|Height|Hip circumference|Waist circumference|Weight","Cardiovascular|Hearing and Vision|Respiratory",Blood|Saliva|Urine,"Gene screening","Magnetic resonance imaging (MRI)","Consent for brain donation","Alcohol|Physical activity|Smoking","Education|Ethnic group|Income and finances|Martial status|Occupation and employment","Formal health and social care service utilisation including private care","Albert Einstein College of Medicine",
"Erasmus Rucphen Family Study","A family-based cohort study that is embedded in the Genetic Research in Isolated Populations (GRIP) program in the South West of the Netherlands. The aim of this program was to identify genetic risk factors in the development of complex disorders. For the ERF study, 22 families that had at least five children baptized in the community church between 1850-1900 were identified with the help of genealogical records. All living descendants of these couples and their spouses were invited to take part in the study. Data collection started in June 2002 and was finished in February 2005 (n=2065).",ERF,"The aim of the Erasmus Rucphen Family (ERF) study was to identify genetic risk factors in the development of complex disorders. Data collection started in June 2002 and was finished in February 2005 (n=2065).",Jun-02,"0 to 4,999","Dr. Cornelia van Duijn and Dr Aaron Issacs","http://www.gefos.org/?q=content/erasmus-rucphen-family-study-2","c.vanduijn@erasmusmc.nl","+31 (0) 10 70 43394 or +31 (0) 10 70 38194","Department of Epidemiology
Erasmus Medical Center
PO Box 2040
3000 CA Rotterdam
the Netherlands","European Commission, European Communitys Seventh Framework Programme",Jun-02,"2,065",17-80,,"Alzheimer's disease|Dementia (unclassified)|Frontotemporal dementia|Huntington's disease|Lewy body disease|Mild cognitive impairment (MCI)|Motor neurone disease|Other NDs not listed|Parkinson's disease|Prion disease|Spinal muscular atrophy (SMA)|Spinocerebellar ataxia (SCA)|Subjective memory complaints (SMC) or subjective cognitive decline (SCD)|Vascular dementia",,"Condition diagnosed",Netherlands,,"0 to 4,999","10 to 19|20 to 39|40 to 59|60 to 100",,"Individual physiological","Blood pressure|Height|Hip circumference|Waist circumference|Weight","Cardiovascular|Hearing and Vision|Musculoskeletal|Reproductive|Respiratory",Blood,"Gene screening","Electroencephalogram (EEG)|Magnetic resonance imaging (MRI)",,"Alcohol|Physical activity|Smoking","Education|Ethnic group|Family circumstances|Income and finances|Informal support|Martial status|Occupation and employment|Unpaid care",,"Erasmus Medical Center",
"Hisayama Study","A population-based prospective study of cerebro-cardiovascular diseases was begun in 1961 in the town of Hisayama, a suburb of the Fukuoka metropolitan area of Kyushu Island in Japan. In addition, comprehensive surveys of cognitive impairment in the elderly of this town have been conducted since 1985. In 1988, a total of 1,228 residents aged ?60 years (91.1% of the total population in this age group) participated in a screening examination for the present study. After exclusion of 33 subjects who had dementia, 90 who had already had breakfast, 5 who were on insulin therapy, and 81 who could not complete the OGTT, a total of 1,019 subjects without dementia underwent the OGTT. From a total of 1,019 subjects, 2 who died before starting follow-up were excluded, and the remaining 1,017 subjects (437 men and 580 women) were enrolled in this study.
The subjects were followed up prospectively for 15 years, from December 1988 to November 2003 (mean 10.9 years; SD 4.1 years).",,"A population-based prospective study of cerebro-cardiovascular diseases was begun in 1961 in the town of Hisayama, Japan. The subjects were followed up prospectively for 15 years, from December 1988 to November 2003.",1985-2017,,"Professor Toshiharu Ninomiya","http://www.epi.umn.edu/cvdepi/study-synopsis/hisayama-study/","nino@eph.med.kyushu-u.ac.jp; ohara77@npsych.med.kyushu-u.ac.jp",,"Department of Epidemiology and Public Health,
Graduate School of Medical Sciences,
Kyushu University Fukuoka,
Japan","The Ministry of Education, Culture, Sports, Science and Technology of Japan, Ministry of Health, Labour and Welfare of Japan",1985-2017,,"> 60",,"Alzheimer's disease|Mild cognitive impairment (MCI)|Vascular dementia",,"No diagnosis",Japan,,"0 to 4,999","60 to 100",,"Individual physiological","Blood pressure|Height|Waist circumference|Weight",Cardiovascular|Respiratory,Blood,"Gene screening","Magnetic resonance imaging (MRI)","Consent for brain donation","Alcohol|Dietary habits|Physical activity|Smoking","Education|Occupation and employment",,"Kyushu University",
"Jackson Heart Study","The primary objective of the Jackson Heart Study is to investigate the causes of cardiovascular disease (CVD) in African Americans to learn how to best prevent this group of diseases in the future.
Specific objectives include:
 Identification of factors, which influence the development, and worsening of CVD in African Americans, with an emphasis on manifestations related to high blood pressure (such as remodeling of the left ventricle of the heart, coronary artery disease, heart failure, stroke, and disorders affecting the blood vessels of the kidney).
 Building research capabilities in minority institutions at the undergraduate and graduate level by developing partnerships between minority and majority institutions and enhancing participation of minority investigators in large-scale epidemiologic studies.
 Attracting minority students to and preparing them for careers in health sciences.
The Jackson Heart Study conducted three cohort examinations, an initial clinic examination from 2000 to 2004 (Exam1), followed by a second exam from 2005 to 2008 (Exam 2) and a final exam in 2009 to 2013 (Exam 3). Starting in 2001, participants have been contacted annually, and ascertainment of hospitalizations for cardiovascular events and deaths is ongoing.",JHS,"The primary objective of the Jackson Heart Study is to investigate the causes of cardiovascular disease (CVD) in African Americans to learn how to best prevent this group of diseases in the future. Starting in 2001, participants have been contacted annually.",2000-2004,"0 to 4,999","Professor Adolfo Correa","https://www.jacksonheartstudy.org/","jhsccrc@umc.edu; Acorrea@umc.edu",601-815-5775,"University of Mississippi Medical Center
Department of Medicine
Jackson
Mississippi, United States","The National Heart, Lung, and Blood Institute (NHLBI)
National Institute on Minority Health and Health Disparities (NIMHD)",2000-2004,"4,000",35-84,,,,"No diagnosis",USA,,"5,000 to 9,999","20 to 39|40 to 59|60 to 100",,,"Blood pressure|Height|Hip circumference|Waist circumference|Weight","Cardiovascular|Hearing and Vision|Reproductive|Respiratory",Blood|Urine,"Gene screening",,,"Alcohol|Dietary habits|Physical activity|Smoking","Education|Ethnic group|Family circumstances|Housing and accommodation|Income and finances|Informal support|Martial status|Occupation and employment","Formal health and social care service utilisation including private care","University of Mississippi",
"Longitudinal Study of Generations","The Longitudinal Study of Generations (LSOG), initiated in 1971, began as a survey of intergenerational relations among 300 three-generation California families with grandparents (then in their sixties), middle-aged parents (then in their early forties), and grandchildren (then aged 15 to 26). The study broadened in 1991 and now includes a fourth generation, the great-grandchildren of these same families.
The study objectives were:
 To track life-course trajectories of family intergenerational solidarity and conflict over three decades of adulthood, and across successive generations of family members;
 To identify how intergenerational solidarity and conflict influence the well-being of family members throughout the adult life-course and across successive generations;
 To chart the effects of socio-historical change on families, intergenerational relationships, and individual life-course development during the past three decades;
 To examine women's roles and relationships in multigenerational families over 30 years of rapid change in the social trajectories of women's lives.
The Longitudinal Study of Generations (LSOG), initiated in 1971, began as a survey of intergenerational relations among 300 three-generation California families with grandparents (then in their sixties), middle-aged parents (then in their early forties), and grandchildren (then aged 15 to 26). The study broadened in 1991 and now includes a fourth generation, the great-grandchildren of these same families.",LSOG,"The Longitudinal Study of Generations (LSOG), initiated in 1971, began as a survey of intergenerational relations among 300 three-generation California families with grandparents, middle-aged parents, and grandchildren.",1971,"0 to 4,999","Dr. Merril Silverstein","http://www.icpsr.umich.edu/icpsrweb/NACDA/studies/22100","merrils@syr.edu","(315) 443-3969","Syracuse University
Aging Studies Institute
Syracuse
New York
USA","United States Department of Health and Human Services
National Institutes of Health
National Institute on Aging",1971,"1,682","15 +",,"Alzheimer's disease",,"No diagnosis",USA,,"0 to 4,999","10 to 19|20 to 39|40 to 59|60 to 100",,"Individual physiological|Individual psychological",,"Hearing and Vision|Musculoskeletal",,,,,"Alcohol|Dietary habits|Physical activity|Smoking","Education|Ethnic group|Family circumstances|Housing and accommodation|Income and finances|Informal support|Martial status|Occupation and employment|Unpaid care","Formal health and social care service utilisation including private care","Syracuse University",
"The New England Centenarian Study","Convenience sample of centenarians, their siblings, offspring, spouses and a control sample consisting of people born around same time as offspring but who do not have parents surviving beyond average life expectancy for their birth cohort. Age range 40-119 years, with ~2500 centenarians in the sample including 600 semi-supercentenarians (ages 105-109) and 200 supercentenarians (ages 110+ years).
We collect the below listed data at enrolment and then collect vital status, hospitalization, changes in meds and diagnoses, cognitive function (TICS) and physical function (IADS, ADL) over the phone, annually. Local subjects are asked to undergo annual detailed cognitive function testing in person with ultimately, brain donation. Blood sample collected at enrolment for DNA, RNA and plasma for biomarkers and storage.
Study is open to collaborations. Please contact Dr. Perls",NECS,"Convenience sample of centenarians, their siblings, offspring, spouses and a control sample consisting of people born around same time as offspring but who do not have parents surviving beyond average life expectancy for their birth cohort. Age range 40-119 years, with ~2500 centenarians in the sample including 600 semi-supercentenarians (ages 105-109) and 200 supercentenarians (ages 110+ years).",1995-present,"0 to 4,999","Dr Thomas Perls","http://www.bumc.bu.edu/centenarian/","michel.vaillant@lih.lu ; PI Email: thperls@bu.edu","+1 617-638-6688 Tel US Toll-Free: 888-333-6327","New England Centenarian Study
Section of Geriatrics, Robinson 2400
Boston Medical Center
88 E. Newton Street, Robinson 2400
Boston, MA 02118","National Institute on Aging
The William M. Wood Foundation
The Martin and Paulette Samowitz Family Foundation",1995-present,"4,000",40-119,,"Alzheimer's disease|Dementia (unclassified)|Huntington's disease|Mild cognitive impairment (MCI)|Parkinson's disease|Subjective memory complaints (SMC) or subjective cognitive decline (SCD)",,"No diagnosis",USA,,,"40 to 59|60 to 100",,,"Blood pressure|Height|Weight",,Blood|Other,"Gene screening",,"Consent for brain donation","Alcohol|Dietary habits|Physical activity|Smoking","Education|Ethnic group|Family circumstances|Housing and accommodation|Income and finances|Informal support|Martial status|Occupation and employment|Unpaid care","Formal health and social care service utilisation including private care",,
"Nurses’ Health Study I","The Nurses' Health Study is a longitudinal population study aimed initially to examine the relation between the use of oral contraceptives, cigarette smoking, and risk of major illnesses in women, mainly cancer and cardiovascular diseases. Since then, the study broadened to include the evaluation of health consequences of many lifestyle practices, including diet, physical activity, and specific forms of hormone therapy.
The participants are registered nurses, aged 30 to 55 years and married at the time of recruitment in 1976, and who lived in the 11 most populous states (California, Connecticut, Florida, Maryland, Massachusetts, Michigan, New Jersey, New York, Ohio, Pennsylvania and Texas).",NHS1,"The Nurses' Health Study is a longitudinal population study aimed initially to examine the relation between the use of oral contraceptives, cigarette smoking, and risk of major illnesses in women, mainly cancer and cardiovascular diseases.",1976,"50,000 to 99,999","Francine Grodstein and Meir Stampfer","http://www.nurseshealthstudy.org/","nhs@channing.harvard.edu PI email: mstampfe@hsph.harvard.edu; Francine.Grodstein@channing.harvard.edu",617-525-2279,"Nurses' Health Study
Channing Division of Network Medicine
181 Longwood Avenue
Boston, MA 02115","National Institute of Health (NIH), National Institute for Occupational Safety and Health (NIOSH) and the Breast Cancer Foundation",1976,"70,000",30-55,,"Mild cognitive impairment (MCI)|Motor neurone disease|Parkinson's disease|Subjective memory complaints (SMC) or subjective cognitive decline (SCD)",,"No diagnosis",USA,,"100,000 to 499,999","20 to 39|40 to 59",,"Individual physiological|Individual psychological","Blood pressure|Height|Hip circumference|Waist circumference|Weight","Cardiovascular|Hearing and Vision|Musculoskeletal|Reproductive|Respiratory",Blood|Saliva|Urine,,,,"Alcohol|Dietary habits|Physical activity|Smoking","Education|Ethnic group|Family circumstances|Housing and accommodation|Income and finances|Informal support|Martial status|Occupation and employment|Unpaid care","Formal health and social care service utilisation including private care","Brigham and Womens Hospital and Harvard Medical School",
"National Longitudinal Study of Youth 1979","The NLSY 1979 Cohort is a longitudinal project that follows the lives of 12,686 American youth born between 1957 and 1964. The study was intended to be representative of United States residents, both male and female. It observes the life-course experiences of young adults who were finishing their schooling and were making decisions about education and training, entering the labour market, military service, marriage, and having families. Cohort members are now in their 50s and survey content has turned to age-appropriate topics including health and retirement expectations.
Yearly personal interviews were conducted from 1979 - 1986. In 1987, a telephone interview was conducted. Personal interviews resumed in 1988 and continued yearly until 1994. Since 1994, NLSY79 participants have been interviewed in even-numbered years.",NLSY79,"The NLSY 1979 Cohort is a longitudinal project that follows the lives of 12,686 American youth born between 1957 and 1964.",1979,,"Dr Deborah Carr","https://www.nlsinfo.org/content/cohorts/nlsy79","cooksey.1@osu.eduu; PI email: carrds@bu.edu","(614) 442-7362","CHRR at The Ohio State University
921 Chatham Ln Suite 200
Columbus, OH 43221","National Longitudinal Surveys  U.S Bureau of Labour Statistics",1979,,14-22,,,,"No diagnosis",USA,,"10,000 to 19,999","20 to 39",,"Individual psychological","Blood pressure|Height|Weight","Cardiovascular|Hearing and Vision|Reproductive|Respiratory",,,,,"Alcohol|Dietary habits|Physical activity|Smoking","Education|Ethnic group|Family circumstances|Housing and accommodation|Income and finances|Martial status|Occupation and employment",,"The Ohio State University",
"Parkinson’s Repository of Biomarkers and Networked Datasets","Tracking Parkinson's, or the PRoBaND study, is a UK-based study of Parkinson's disease funded entirely by Parkinson's UK.
There is a wide variation of symptoms and features of Parkinson's driven by both genetic and external factors. Our study aims to define and explain these variations by analysing the clinical expression of Parkinson's in relation to genotypic variation. Tracking Parkinson's is a multi-centre prospective longitudinal study, informed by epidemiological and biomarker data.
Participants were recruited into three categories:

Recent onset patients (diagnosed within the last three years) are followed up at 6-month intervals for four years, then every 18-months for a further three years.

Early onset (patients diagnosed before the age of 50) were followed up at one year.

Relatives (siblings) of the participants are followed up after three years.

Since 2012, we have been running at 70 sites across the UK. Recruitment closed in November 2017 and our cohort consists of 2,270 people with Parkinson's and 344 of their siblings.
NHS Greater Glasgow & Clyde is the study Sponsor and the coordinating study centre is based at the Institute of Neuroscience & Psychology at the University of Glasgow in Scotland.",PRoBaND,"There is a wide variation of symptoms and features of Parkinson's driven by both genetic and external factors. Our study aims to define and explain these variations by analysing the clinical expression of Parkinson's in relation to genotypic variation. Recruitment closed in November 2017 and our cohort consists of 2,270 people with Parkinson's and 344 of their siblings.",2012-2017,"2,614","Donald Grosset","www.trackingparkinsons.org.uk","tracking-parkinsons@glasgow.ac.uk","Tel: +44 0141 330 2058","Tracking Parkinson's
Institute of Neuroscience & Psychology
University of Glasgow
58 Hillhead Street, Room 702
Glasgow
G12 8QB
United Kingdom","Parkinson's Disease UK",2012-2017,"2,614",,14/05/2018,"Parkinson's disease",,"At-risk diagnosis|Condition diagnosed|No diagnosis","United Kingdom",,"0 to 4,999",,,"Caregiver|Individual physiological","Blood pressure|Height|Weight",,Blood,"Gene screening",,,"Dietary habits|Physical activity","Ethnic group|Family circumstances|Martial status","Formal health and social care service utilisation including private care","University of Glasgow",
"The Swedish National study on Aging and Care in Kungsholmen","In 1999 the Swedish Ministry for Social Affairs promoted and supported a national project aimed at monitoring and evaluating the care-of-the-elderly system in Sweden. To achieve these aims, four longitudinal individual-based data collection describing the aging process and encompassing the care system as whole, has been initiated. This project was named The Swedish National study on Aging and Care (SNAC).
SNAC-K is conducted by the Stockholm Gerontology Research Center in collaboration with Aging Research Center (ARC), Karolinska Institutet.
SNAC-K includes two studies: SNAC-K population study and SNAC-K care system study.",SNAC-K,"The Swedish Ministry for Social Affairs promoted and supported a national project aimed at monitoring and evaluating the care-of-the-elderly system in Sweden. SNAC-K includes two studies: SNAC-K population study and SNAC-K care system study.","2001-2004, 2007-2009, 2010-2012 and 2013-2015","0 to 4,999","PI Population Study: Laura FratiglioniPI Care System Study: Mårten Lagergren","http://www.snac-k.se/","PI Population Study: laura.fratiglioni@ki.seVice PI Population Study: anna-karin.welmer@ki.sePI Care System Study: marten.lagergren@aldrecentrum.se",,"Aging Research Center
Sverige, Gävlegatan 16, 113 30 Stockholm, Sweden","The Ministry of Health and Social Affairs, Sweden
The Stockholm County Council and Municipality
The Swedish Research Council (VR)
The Swedish Research Council for Health, Working life and Welfare (FORTE)","2001-2004, 2007-2009, 2010-2012 and 2013-2015","2,000","> 60",,"Alzheimer's disease|Dementia (unclassified)|Frontotemporal dementia|Lewy body disease|Mild cognitive impairment (MCI)|Other NDs not listed|Subjective memory complaints (SMC) or subjective cognitive decline (SCD)|Vascular dementia",,"No diagnosis",Sweden,,"0 to 4,999","60 to 100",,"Caregiver|Individual psychological","Blood pressure|Height|Hip circumference|Waist circumference|Weight","Cardiovascular|Hearing and Vision|Respiratory",Blood,"Gene screening","Magnetic resonance imaging (MRI)",,"Alcohol|Dietary habits|Physical activity|Smoking","Education|Family circumstances|Housing and accommodation|Informal support|Martial status|Occupation and employment|Unpaid care",,"Karolinska Institutet",
"Stockholm Birth Cohort","The Stockholm Birth Cohort Study (SBC) was created in 2004/2005 by a probability matching of two comprehensive and longitudinal datasets. The first, the Stockholm Metropolitan study 19531985, consists of all children born in 1953 and living in the Stockholm metropolitan area in 1963. The second, The Swedish Work and Mortality Database 19802009 (WMD), consists of all individuals living in Sweden in 1980 or 1990, and born before 1985. The initiative to create the database was taken by Denny Vågerö at the Centre for Health Equity Studies, CHESS, of Stockholm University/Karolinska Institute and Sten-Åke Stenberg at the Swedish Institute for Social Research, Stockholm University (SOFI). The resulting database provides a 50-year long follow-up of the original 1953 birth cohort.",,"The Stockholm Birth Cohort Study (SBC) was created in 2004/2005 by a probability matching of two comprehensive and longitudinal datasets. The resulting database provides a 50-year long follow-up of the original 1953 birth cohort.","November 1st 1963","10,000 to 19,999","Dr Ylva B. Almquist","http://www.stockholmbirthcohort.su.se/","PI e-mail: ylva.almquist@su.se","+46 8 674 79 69","Ylva B. Almquist (Principal investigator)
Department of Public Health Sciences
Stockholms Universitet
SE - 106 91 Stockholm","The Swedish Research Council (VR), The Swedish Research Council for Health, Working Life and Welfare (Forte)","November 1st 1963","13,838",10,,,,"No diagnosis",Sweden,,"10,000 to 19,999","10 to 19",,,Height|Weight,,,,,,"Alcohol|Physical activity|Smoking","Education|Family circumstances|Housing and accommodation|Income and finances|Martial status|Occupation and employment","Formal health and social care service utilisation including private care","Stockholms Universitet",
"The Kungsholmen Project","The Kungsholmen Project is a longitudinal population-based study on ageing and dementia, carried out by the Stockholm Gerontology Research Center in collaboration with Aging Research Center (ARC), Karolinska Institutet.
The project, which started in 1987, has gathered a 12-year long database and offers information on aging from a multidisciplinary perspective. All persons that were born before 1913 and lived in the Kungsholmen district of Stockholm, were invited to participate (a total of 2368 persons on October 1st, 1987, including both community-dwelling and institutionalized persons). Later, the research additionally included all 90+ old subjects living in the St. Göran parish, an adjacent geographical area. The baseline phase and four follow-ups have been completed, with the last phase concluding in the summer of 2000. Time 1 was the only measurement occasion when a two-phase study design was adopted, with an extensive clinical examination performed after a screening phase. At every other occasion, all participants were interviewed by nurses, clinically examined by physicians, and assessed by psychologists.",,"The Kungsholmen Project is a longitudinal population-based study on ageing and dementia. The project, which started in 1987, has gathered a 12-year long database and offers information on aging from a multidisciplinary perspective.","1st October 1987",,"Bengt Winblad","http://www.kungsholmenproject.se/","maria.wahlberg@ki.sePI Email: Laura.Fratiglioni@ki.se",,"Aging Research Center
Gävlegatan 16, SE-113 30 Stockholm
Sweden","Stockholm Gerontology Research Center in collaboration with Aging Research Center (ARC)","1st October 1987",,"> 75",,"Alzheimer's disease|Dementia (unclassified)|Mild cognitive impairment (MCI)|Other NDs not listed|Parkinson's disease|Subjective memory complaints (SMC) or subjective cognitive decline (SCD)|Vascular dementia",,"No diagnosis",Sweden,,"0 to 4,999","60 to 100",,"Caregiver|Individual physiological|Individual psychological","Blood pressure|Height|Weight","Cardiovascular|Hearing and Vision|Musculoskeletal|Respiratory",Blood,"Gene screening",,,"Alcohol|Dietary habits|Physical activity|Smoking","Education|Family circumstances|Housing and accommodation|Informal support|Martial status|Occupation and employment|Unpaid care","Formal health and social care service utilisation including private care","Stockholm Gerontology Research Center",
"Vellore Birth Cohort","The original study (1969-73) had five main objectives: (i) to study the relationship of birth weight (BW) and gestational age (GA) to infant mortality and the incidence of congenital defects; (ii) to study maternal blood pressure before and during pregnancy and the incidence of toxaemia; (iii) to assess the effects of parental consanguinity on reproductive outcomes; (iv) to examine the impact of family planning programmes on fertility and (v) to estimate rates of foetal loss, and neonatal, infant and early childhood mortality.1 The subsequent follow-up studies focused on the effects of prenatal factors BW and GA on physical growth and development and mortality during childhood and adolescence.
For the follow-up in young adulthood (1998-2002), the main objective was to study glucose tolerance, insulin resistance and insulin secretion and a range of cardiovascular risk factors (body composition, blood pressure and plasma lipid concentrations) in relation to parental size, neonatal size and childhood growth.",,"The follow-up in young adulthood (1998-2002), the main objective was to study glucose tolerance, insulin resistance and insulin secretion and a range of cardiovascular risk factors (body composition, blood pressure and plasma lipid concentrations) in relation to parental size, neonatal size and childhood growth.",1969-1973,"0 to 4,999","Dr Antonisamy, Dr Vasan and Professor Fall","https://academic.oup.com/ije/article/38/3/663/682164/Cohort-Profile-The-1969-73-Vellore-birth-cohort","PI email: antoni@cmcvellore.ac.in; b.antonisamy@gmail.com; senthil.vasan@ocdem.ox.ac.uk; chdf@mrc.soton.ac.ukContact Email: prasanna_samuel@hotmail.com","+91 416 2262703 (off.); +91 416 2284205","Department of Biostatistics
Christian Medical College
Vellore  632002
Tamil Nadu, India","US National Center for Health Statistics",1969-1973,"2,218","26 -32",,,,"No diagnosis",India,,"10,000 to 19,999","20 to 39",,,"Blood pressure|Height|Hip circumference|Waist circumference|Weight","Cardiovascular|Hearing and Vision|Musculoskeletal|Reproductive",Blood,"Gene screening",,,"Alcohol|Dietary habits|Physical activity|Smoking","Education|Family circumstances|Housing and accommodation|Income and finances|Occupation and employment",,"Christian Medical College, Vellore",
"The Uppsala Birth Cohort Multigeneration Study","The Uppsala Birth Cohort Multigeneration Study (UBCoS) started in 2005 when we were first able to combine existing data on a representative and well-defined cohort of 14,192 males and females born in Uppsala from 1915-1929 (the Uppsala Birth Cohort: UBCoS) with information on descendants of the original cohort members obtained from routine registers.
In 2007-2011, the study was further developed by additional data collection in school archives and records from Census 1930 and the period of follow-up was extended till end of year 2009.
The study is unique in investigating intergenerational effects as ""forward in time"" processes, starting at the beginning of the last century (i.e. well before any of the routine registers were in place). Intergenerational associations can be currently investigated in more than 140,000 study subjects from families spanning up to five generations, including the 14,192 original cohort members, their 22,559 children, 38,771 grandchildren and 25,471 great grandchildren born up to 2009.",UBCoS,"The Uppsala Birth Cohort Multigeneration Study (UBCoS) started in 2005 when we were first able to combine existing data on a representative and well-defined cohort of 14,192 males and females born in Uppsala from 1915-1929 (the Uppsala Birth Cohort: UBCoS) with information on descendants of the original cohort members obtained from routine registers.","1994, 2005","100,000 to 499,999","Professor Ilona Koupil","http://www.chess.su.se/ubcosmg/","ilona.koupil@su.se","+46 73 572 2932","Centre for Health Equity Studies (CHESS)
Dept Public Health Sciences
Stockholms universitet / Karolinska Institutet
SE - 106 91 Stockholm","Swedish Research Council, Swedish Research Council for Health, Working Life and Welfare, European Commission","1994, 2005",140000,0,,"Alzheimer's disease|Dementia (unclassified)|Frontotemporal dementia|Huntington's disease|Lewy body disease|Mild cognitive impairment (MCI)|Motor neurone disease|Other NDs not listed|Parkinson's disease|Prion disease|Spinal muscular atrophy (SMA)|Spinocerebellar ataxia (SCA)|Vascular dementia",,"No diagnosis",Sweden,,"10,000 to 19,999","0 to 9",,,Height|Weight,,,,,,,"Education|Ethnic group|Family circumstances|Income and finances|Martial status|Occupation and employment","Formal health and social care service utilisation including private care","Karolinska Institutet|Stockholms Universitet",
"Prospective Epidemiological Risk Factor Study","The Prospective Epidemiological Risk Factor (PERF) Study is an ambidirectional population-based study of postmenopausal women set up with the purpose of obtaining a better understanding of the aetiology and pathogenesis of age-related diseases. Participants were recruited from a source population of 8875 women residing in Denmark. The baseline examination (PERF I) comprised 5855 women with mean age of 70.8 years (49.7-88.8) and took place between 1999 and 2001. All subjects have been followed up with registry linkage using population-based national registries. Further, a subcohort was re-invited to attend a follow-up visit between 2013 and 2014 (PERF II). Registry data are available for all baseline participants. From the baseline population, 2103 were enrolled in PERF II.",PERF,"The Prospective Epidemiological Risk Factor (PERF) Study is an ambidirectional population-based study of postmenopausal women set up with the purpose of obtaining a better understanding of the aetiology and pathogenesis of age-related diseases.","1999-2001; 2013-2014",,"Dr Cecilie Liv Bager and Morten Karsdal","http://www.nordicbioscience.com/expertise/publications/cohort-profile-the-prospective-epidemiological-risk-factor-perf-study/","erf@nordicbio.com; PI Email: cba@nordicbio.com",,"Nordic Bioscience A/S,
Herlev Hovedgade 207,
DK-2730 Herlev,
Denmark","Danish Research Foundation","1999-2001; 2013-2014",,49-88,,"Alzheimer's disease|Dementia (unclassified)|Frontotemporal dementia|Huntington's disease|Lewy body disease|Mild cognitive impairment (MCI)|Motor neurone disease|Other NDs not listed|Parkinson's disease|Prion disease|Spinal muscular atrophy (SMA)|Spinocerebellar ataxia (SCA)|Subjective memory complaints (SMC) or subjective cognitive decline (SCD)|Vascular dementia",,"At-risk diagnosis",Denmark,,"0 to 4,999","40 to 59|60 to 100",,,"Blood pressure|Height|Hip circumference|Waist circumference|Weight",Cardiovascular|Musculoskeletal|Reproductive|Respiratory,Blood|Urine,"Gene screening",,,"Alcohol|Dietary habits|Physical activity|Smoking","Education|Ethnic group|Family circumstances|Marital status|Occupation and employment","Formal health and social care service utilisation including private care","Nordic Bioscience",
"Scottish Health Survey","The Scottish Health Survey (SHeS) provides a detailed picture of the health of the Scottish population in private households and is designed to make a major contribution to the monitoring of health in Scotland.
The series aims to:
 estimate the occurrence of particular health conditions
 estimate the prevalence of certain risk factors associated with health
 look at differences between regions and between subgroups of the population
 monitor trends in the population's health over time
 make a major contribution to monitoring progress towards health targets",SHeS,"The Scottish Health Survey (SHeS) provides a detailed picture of the health of the Scottish population in private households. SHeS has recurited 4,323 participants.",1995-2016,"0 to 4,999",,"http://www.gov.scot/Topics/Statistics/Browse/Health/scottish-health-survey","Scottish_Health_Survey@gov.scot","Julie Landsberg 0131 244 2368Andrew Paterson 0131 244 3201Scott Jackson 0131 244 4098","Analytical Services (HD)
Population Health (ASD Health)
Basement Rear, St. Andrews House
Regent Road
Edinburgh
EH1 3DG","Scottish Government",1995-2016,"4,659",>0,,,,"No diagnosis","United Kingdom",,"0 to 4,999","0 to 9|10 to 19|20 to 39|40 to 59|60 to 100",,,"Blood pressure|Height|Hip circumference|Waist circumference|Weight",Cardiovascular|Respiratory,Blood|Saliva|Urine,,,,"Alcohol|Dietary habits|Physical activity|Smoking","Education|Ethnic group|Family circumstances|Housing and accommodation|Income and finances|Informal support|Marital status|Occupation and employment|Unpaid care",,"Scottish Government",
"Scottish Longitudinal Study","The Scottish Longitudinal Study (SLS) is a large-scale linkage study created using data from administrative and statistical sources. These include: census data from 1991 onwards; vital events data (births, deaths, marriages); NHS Central Register data (gives information on migration into or out of Scotland); and education data (including Schools Census and SQA data).",SLS,"The Scottish Longitudinal Study (SLS) is a large-scale linkage study created using data from administrative and statistical sources. SLS has recurited 274,000 participants.","1991 - present",,"Professor Chris Dibben","http://sls.lscs.ac.uk/about/","sls@lscs.ac.uk; PI Email: chris.dibbens@ed.ac.uk; SLS Project Manager (NRS): Robin.Frost@nrscotland.gov.uk","Tel: 0131 314 4310","Scottish Longitudinal Study Development & Support Unit
Ladywell House
Ladywell Rd
Edinburgh
EH12 7UR","ESRC, National Records Scotland","1991 - present",,>0,,,,"No diagnosis","United Kingdom",,"100,000 to 499,999","0 to 9|10 to 19|20 to 39|40 to 59|60 to 100",,,,Reproductive,,,,,,"Education|Ethnic group|Family circumstances|Housing and accommodation|Income and finances|Informal support|Marital status|Occupation and employment|Unpaid care","Formal health and social care service utilisation including private care",,
"The Limache cohort","The Limache cohort was set up to assess the programming and life course events hypotheses in relation to cardiovascular risk factors and chronic respiratory conditions, especially asthma, in the context of an unprecedented economic growth in Chile. The cohort was a representative sample of 1,232 participants born between 1974 and 1978 in the hospital of Limache. The study includes data collected at birth, during the 1st year of life, at 22 to 28 years (collected between 2000 and 2002) and at 32 to 38 years (collected between 2010 and 2012).
This was possible because details were collected for all births in the country including duration of gestation, birthweight and birth length. Limache, a semirural agricultural area relatively near Santiago and close to Viña del Mar and Valparaíso, was chosen because: a birth register in the hospital has been kept since the 1970s; paediatric clinical records were kept in the local hospital ; and there was demographic information that emigration from this area was low so that we would be able to find most participants born in the 1970s still living in Limache and in Olmué, a neighbouring area.",,"The Limache cohort was set up to assess the programming and life course events hypotheses in relation to cardiovascular risk factors and chronic respiratory conditions, especially asthma, in the context of an unprecedented economic growth in Chile. The Limache cohort has 1,232 participants",1999,,"Hugo Amigo, Patricia Bustos","https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4121550/","PI Email (Chile): hamigo@med.uchile.cl; pbustos@med.uchile.cl; PI Email (Kings College London): roberto.rona@kcl.ac.uk","Tel: +56 2 2978 6213","Department of Nutrition,
Faculty of Medicine,
University of Chile,
Independencia 1027
Santiago
Chile","Wellcome Trust, National Research Fund of Chile",1999,,>22,,,,"No diagnosis",Chile,,"0 to 4,999","20 to 39|40 to 59|60 to 100",,,"Blood pressure|Height|Waist circumference|Weight",Cardiovascular|Respiratory,Blood,,,,"Alcohol|Dietary habits|Physical activity|Smoking","Family circumstances|Housing and accommodation|Income and finances|Informal support|Occupation and employment",,"University of Chile",
"The Maastricht Study","The Maastricht Study is an extensive phenotyping study that focuses on the etiology of type 2 diabetes, its classic complications (cardiovascular disease, nephropathy, neuropathy and retinopathy), and its emerging comorbidities, including cognitive decline, depression, and gastrointestinal, respiratory and musculoskeletal diseases. The study uses advanced state-of-the-art imaging techniques and extensive biobanking to determine health status in a population-based cohort of 10,000 individuals that is enriched with type 2 diabetes participants. The Maastricht Study is expected to become one of the most extensive phenotyping studies in both the general population and type 2 diabetes participants worldwide.
The Maastricht Study allows researchers access to data to encourage publications of high quality papers and presentations. External researchers (those without an MUMC or UM affiliation) can only submit a research proposal in cooperation with a member of the Maastricht Study Management Team and/or Maastricht Study Participating researchers.",,"The Maastricht Study is an extensive phenotyping study that focuses on the etiology of type 2 diabetes, its classic complications and its emerging comorbidities, including cognitive decline. The Maastricht Study has recruited 7,500 participants.",,"5,000 to 9,999","Miranda Schram, Coen Stehouwer","https://www.demaastrichtstudie.nl/research","demaastrichtstudie@mumc.nl; m.schram@maastrichtuniversity.nl","Tel: +31 (0) 43 - 387 66 00","Maastricht University Medical Center
Research Center Maastricht Study
Randwycksingel 35
6229 EG Maastricht","European Regional Development Fund, Stichting De Weijerhorst (Maastricht, the Netherlands), the Pearl String Initiative Diabetes (Amsterdam, the Netherlands), the Cardiovascular Center (CVC, Maastricht, the Netherlands), School for Mental Health and Neuroscience (MHeNS), Maastricht, The Netherlands), Cardiovascular Research Institute Maastricht (CARIM, Maastricht, the Netherlands), School for Public Health and Primary Care (CAPHRI, Maastricht, the Netherlands), School for Nutrition, Toxicology and Metabolism (NUTRIM, Maastricht, the Netherlands), Stichting Annadal (Maastricht, the Netherlands), Health Foundation Limburg (Maastricht, the Netherlands) and by unrestricted grants from Janssen-Cileg B.V. (Tilburg, the Netherlands), Novo Nordisk Farma B.V. (Alphen aan den Rijn, the Netherlands) and Sanofi-Aventis Netherlands B.V. (Gouda, the Netherlands).",,"7,500",40-75,,,,"Condition diagnosed",Netherlands,,"10,000 to 19,999","40 to 59|60 to 100",,"Individual physiological|Individual psychological","Blood pressure|Height|Hip circumference|Waist circumference|Weight",Cardiovascular|Musculoskeletal|Respiratory,Blood|Microbiome|Urine,"Gene screening","Magnetic resonance imaging (MRI)",,"Alcohol|Dietary habits|Physical activity|Smoking","Education|Ethnic group|Income and finances|Informal support|Marital status|Occupation and employment","Formal health and social care service utilisation including private care","Maastricht University",
"The Moli-sani Study","The Moli-sani study (www.moli-sani.org) is a cohort study aiming at evaluating the risk factors (environmental, genetics, bio-molecular) linked to chronic-degenerative disease with particular regard to cancer, cardiovascular, cerebrovascular and neurodegenerative disease.
The study has recruited, between March 2005 and April 2010, 24,325 people aged ³ 35 living in the Molise region, from city hall registries by a multistage sampling. Exclusion criteria were pregnancy at the time of recruitment, disturbances in understanding or willingness, current poly-traumas or coma, or refusal to sign the informed consent. Participation rate was 70%.
All subjects underwent electrocardiogram and spirometric tests aimed to evaluate pulmonary diffusion capacity, gas diffusion and pulmonary volumes through plethysmography.
The European Prospective Investigation into Cancer and Nutrition FFQ was used to determine daily nutritional intakes consumed in the past year.
A follow-up based on linkage with hospital discharge records (SDO) and mortality regional registry was performed at December 2011 with a median of 4.3 years and at December 2014 with a median of 9.6 years. Outcomes analysed at follow-up are: mortality for any and specific causes, hospitalization and hospital stay, coronary artery disease, stroke, atrial fibrillation, heart failure, diabetes, cancer.",,"The Moli-sani study is a cohort study aiming at evaluating the risk factors linked to chronic-degenerative disease with particular regard to cancer, cardiovascular, cerebrovascular and neurodegenerative disease. The Moli-sani study has recruited 24,325 participants",2005-2010,,"Prof. Licia Iacoviello and Prof. Giovanni de Gaetano","http://www.moli-sani.org","info@moli-sani.org; PI email: licia.iacoviello@moli-sani.org; giovanni.degaetano@moli-sani.org",,"Via dell Elettronica
86077 Pozzilli (IS).
Italy","Pfizer Italia Foundation and Italian Ministry of University and Research (MIUR)",2005-2010,"24,325",>35,,,,"No diagnosis",Italy,,"20,000 to 49,999",,,"Individual psychological","Blood pressure|Height|Hip circumference|Waist circumference|Weight",Cardiovascular|Musculoskeletal|Reproductive,Blood|Urine,"Gene screening",,,"Alcohol|Dietary habits|Physical activity|Smoking","Education|Ethnic group|Family circumstances|Housing and accommodation|Income and finances|Marital status|Occupation and employment","Formal health and social care service utilisation including private care","IRCCS Istituto Neurologico Mediterraneo - NEUROMED",
"UK Biobank","UK Biobank is a major national health resource, and a registered charity in its own right, with the aim of improving the prevention, diagnosis and treatment of a wide range of serious and life-threatening illnesses  including cancer, heart diseases, stroke, diabetes, arthritis, osteoporosis, eye disorders, depression and forms of dementia.
500,000 people aged between 40-69 years were recruited in 2006-2010 from across the country to take part in this project. They have undergone measures, provided blood, urine and saliva samples for future analysis, detailed information about themselves and agreed to have their health followed. The cohort is primarily followed through data linkage but the cohort was re-contacted in 2012-13 with a further 100,000 to be approached over the next few years.",,"UK Biobank is a major national health resource with the aim of improving the prevention, diagnosis and treatment of a wide range of serious and life-threatening illnesses. UK Biobank has recruited 500,000 participants.",2006-2010,"500,000+","Professor Sir Rory Collins, Chief Scientist, Professor Cathie Sudlow","http://www.ukbiobank.ac.uk; http://imaging.ukbiobank.ac.uk ","enquiries@ukbiobank.ac.uk Chief Scientist email: cathie.sudlow@ed.ac.uk","Telephone: 0800 0 276 276","UK Biobank
1-2 Spectrum Way
Adswood
Stockport
SK3 0SA","Medical Research Council
Wellcome Trust
Department of Health
National Institute for Health Research
British Heart Foundation
Diabetes UK
Northwest Regional Development Agency
Welsh Government
Scottish Government",2006-2010,"500,000",49-69,,"Alzheimer's disease|Dementia (unclassified)|Frontotemporal dementia|Huntington's disease|Lewy body disease|Mild cognitive impairment (MCI)|Motor neurone disease|Other NDs not listed|Parkinson's disease|Prion disease|Vascular dementia",,"No diagnosis","United Kingdom",,"500,000+","40 to 59|60 to 100",,,"Blood pressure|Height|Hip circumference|Waist circumference|Weight","Cardiovascular|Hearing and Vision|Musculoskeletal|Respiratory",Blood|Microbiome|Urine,"Gene screening","Magnetic resonance imaging (MRI)",,"Alcohol|Dietary habits|Physical activity|Smoking","Education|Ethnic group|Family circumstances|Housing and accommodation|Income and finances|Informal support|Marital status|Occupation and employment","Formal health and social care service utilisation including private care","UK Biobank",
"The Whitehall II Study","The Whitehall II Study was established in 1985 to investigate the importance of socioeconomic circumstances for health by following a cohort of working men and women aged 35-55 at enrolment. Participants have taken part in twelve data collection phases, seven of which have included a medical screening. The aim of the study is to understand the causes of age-related heterogeneity in health.
By combining the existing 30 years of data on social circumstances, risk factors and chronic disease with new clinical measures of cognitive function, mental disorders and physical functioning, Whitehall II has been transformed interdisciplinary study of ageing. In addition to providing insights into individual and social differences in the development of frailty, disability, dependence, and dementia, the study helps in the determination of optimal time windows and targets for interventions that maximise the potential for healthy-ageing and independent living.","Whitehall II","The Whitehall II Study was established to investigate the importance of socioeconomic circumstances for health by following a cohort of working men and women aged 35-55.",1985,"7,735","Professor Mika Kivimaki",http://www.ucl.ac.uk/whitehallII,"email: whitehall2@public-health.ucl.ac.uk PI email: m.kivimaki@ucl.ac.uk","Tel: 020 7679 5621","Whitehall II
Department of Epidemiology & Public Health
University College London
1-19 Torrington Place
London
WC1E 6BT","Medical Research Council
British Heart Foundation
National Institute on Aging (NIA)",1985,,35-55,10/05/2018,"Dementia (unclassified)",,"No diagnosis","United Kingdom",,"10,000 to 19,999","20 to 39|40 to 59",,"Individual psychological","Blood pressure|Height|Waist circumference|Weight",Cardiovascular|Musculoskeletal|Respiratory,Blood|Saliva|Urine,"Gene screening","Magnetic resonance imaging (MRI)",,"Alcohol|Dietary habits|Physical activity|Smoking","Education|Ethnic group|Family circumstances|Housing and accommodation|Income and finances|Informal support|Marital status|Occupation and employment|Unpaid care","Formal health and social care service utilisation including private care","University College, London",
"Aberdeen Birth Cohort 1921","On 1st June 1932, as part of the Scottish Mental Survey, 87,498 Scottish schoolchildren born in 1921 sat the same test of mental ability: the Moray House Test. In 1997, the Universities of Aberdeen and Edinburgh began to search for men and women still living in Scotland who took part in these tests.
On 1st June 1998, about 80 individuals gathered in the Aberdeen Music Hall to re-sit the test exactly 66 years later. Participants were followed-up 5 times over a 10 year period.
Aberdeen University has followed all of the children born in Aberdeen in 1921, 1936 (see Aberdeen Birth Cohort 1936) and 1950-1956 (see Aberdeen Children of the 1950s) as they grow and age.
Collectively these groups are known as the ABERDEEN BIRTH COHORTS, and have helped to advance our understanding of aging well.
Over the years, researchers have linked the results from these tests to health and social information.
The linked data has been used to answer questions like:
 Does being born very small affect mental health later in life?
 Is the risk of dementia related to childhood intelligence?
 What influences quality of life in old-age?
Participants born in 1921 and 1936 have been invited back for a wide variety of studies at the University. Similar research is being started for the Children of the 1950's group.",ABC1921,"Aberdeen University has followed all of the children born in Aberdeen in 1921, 1936 (see Aberdeen Birth Cohort 1936) and 1950-1956 (see Aberdeen Children of the 1950s) as they grow and age. ABC1921 recruited 87,498 participants.","1st June 1932","0 to 4,999","Prof Alison Murray","http://www.abdn.ac.uk/birth-cohorts/1921/","PI Email: a.d.murray@abdn.ac.uk; PI Email: c.mcneil@abdn.ac.uk","Tel: +44 (0)1224 438353","Aberdeen Birth Cohort 1921 Study
University of Aberdeen
F04
Lilian Sutton Building
University of Aberdeen
Foresterhill
Aberdeen
AB25 2ZD","University of Aberdeen","1st June 1932",80,11,,"Alzheimer's disease|Dementia (unclassified)|Frontotemporal dementia|Mild cognitive impairment (MCI)|Vascular dementia",,"No diagnosis","United Kingdom",,"50,000 to 99,999","10 to 19",,,"Blood pressure|Height|Waist circumference|Weight",,,,"Magnetic resonance imaging (MRI)",,Alcohol|Smoking,"Education|Ethnic group|Family circumstances|Housing and accommodation|Occupation and employment",,"University of Aberdeen",
"Aberdeen Birth Cohort 1936","On 4th June 1947, as part of the Scottish Mental Survey, every Scottish schoolchild born in 1936 sat the same test of mental ability: the Moray House Test. In 1997, Professor Lawrence Whalley discovered the Scottish Mental Survey test records at the Scottish Council for Research in Education in Edinburgh and began to trace people who had sat the test in Aberdeen.
Aberdeen University has followed all of the children born in Aberdeen in 1921, 1936 (see Aberdeen Birth Cohort 1936) and 1950-1956 (see Aberdeen Children of the 1950s) as they grow and age.
Collectively these groups are known as the ABERDEEN BIRTH COHORTS, and have helped to advance our understanding of aging well.
Over the years, researchers have linked the results from these tests to health and social information.
The linked data has been used to answer questions like:
 Does being born very small affect mental health later in life?
 Is the risk of dementia related to childhood intelligence?
 What influences quality of life in old-age?
Participants born in 1921 and 1936 have been invited back for a wide variety of studies at the University. Similar research is being started for the Children of the 1950's group.",ABC1936,"Aberdeen University has followed all of the children born in Aberdeen in 1936, 1921 (see Aberdeen Birth Cohort 1921) and 1950-1956 (see Aberdeen Children of the 1950s) as they grow and age. ABC1936 recruited 75,211 participants.","4th June 1947","0 to 4,999","Prof Alison Murray","https://www.abdn.ac.uk/birth-cohorts/1936/","PI Email: a.d.murray@abdn.ac.uk; c.mcneil@abdn.ac.uk","Tel: +44 (0)1224 438353","Aberdeen Birth Cohort 1936 Study
University of Aberdeen
F04
Lilian Sutton Building
University of Aberdeen
Foresterhill
Aberdeen
AB25 2ZD","University of Aberdeen","4th June 1947",497,11,,"Alzheimer's disease|Dementia (unclassified)|Frontotemporal dementia|Lewy body disease|Mild cognitive impairment (MCI)|Parkinson's disease|Vascular dementia",,"No diagnosis","United Kingdom",,"50,000 to 99,999","10 to 19",,,"Blood pressure|Height|Waist circumference|Weight",,,"Gene screening","Magnetic resonance imaging (MRI)",,"Alcohol|Dietary habits|Physical activity|Smoking","Education|Family circumstances|Housing and accommodation|Martial status|Occupation and employment",,"University of Aberdeen",
"Integrated multidisciplinary approach/ Agrica MSA IFR Public Health 99","The health of the agricultural population has been previously explored, particularly in relation to the farming exposures and among professionally active individuals. However, few studies specifically focused on health and aging among elders retired from agriculture. Yet, this population faces the long-term effects of occupational exposures and multiple difficulties related to living and aging in rural area (limited access to shops, services, and practitioners). However, these difficulties may be counter-balanced by advantages related to healthier lifestyle, richer social support and better living environment. The general aim of the AMI cohort was to study health and aging in elderly farmers living in rural area through a multidisciplinary approach, with a main focus on dementia.
The study started in 2007, with two follow-up visits over 5 years. Baseline visits were conducted at home by a neuropsychologist then by a geriatrician for all cases suspected of dementia, for all subjects suspected of being demented. The 10-year visit is currently on going.",AMI,"The aim of the AMI cohort was to study health and aging in elderly farmers living in rural area through a multidisciplinary approach, with a main focus on dementia. AMI recruited 1000 participants.",2007-present,,"Dartigues Jean-Francois","https://epidemiologie-france.aviesan.fr/en/epidemiology/records/integrated-multidisciplinary-approach-agrica-msa-ifr-public-health-99/eng-gb","PI email: jean-francois.dartigues@u-bordeaux.fr","Tel: +33 (0)5 57 57 15 96","146 rue Léo Saignat 33076 Bordeaux cedex","The Association de Gestion pour le Compte des Institutions Complémentaires Agricoles, the Caisse Mutuelle Autonome de Retraites Complémentaires Agricoles, the Caisse de Retraite Complémentaire des Cadres de lAgriculture, the Caisse Centrale de Prévoyance Mutuelle Agricole Prévoyance, the Caisse de Prévoyance des Cadres dEntreprises Agricoles, Agri Prévoyance, the Mutualité Sociale Agricole de Gironde, the Caisse Centrale de la Mutualité Sociale Agricole, and the Caisse Nationale de Solidarité et dAutonomie, Caisse Nationale de Solidarité pour lAutonomie, SCOR.",2007-present,,>65,,"Alzheimer's disease|Dementia (unclassified)|Frontotemporal dementia|Lewy body disease|Mild cognitive impairment (MCI)|Parkinson's disease|Subjective memory complaints (SMC) or subjective cognitive decline (SCD)|Vascular dementia",,"No diagnosis",France,,"0 to 4,999","60 to 100",,"Caregiver|Individual physiological|Individual psychological","Blood pressure|Height|Hip circumference|Waist circumference|Weight","Cardiovascular|Hearing and Vision|Musculoskeletal|Respiratory",Blood,"Gene screening","Magnetic resonance imaging (MRI)|Positron emission tomography (PET) - amyloid|Positron emission tomography (PET) fluorine18 flurodeoxyglucose (FDG)",,"Alcohol|Dietary habits|Physical activity|Smoking","Education|Family circumstances|Informal support|Martial status|Occupation and employment|Unpaid care","Formal health and social care service utilisation including private care","Unité INSERM U1219",
"British Women’s Heart & Health Study","The British Women's Heart and Health Study is a prospective cohort study of heart disease in over 4000 British women between the ages of 60 and 79. It is funded by the British Heart Foundation. The Study aims to provide information about existing patterns of treatment of heart disease, and further the understanding of risk factors and disease prevention. We collected our baseline data in 1999-2001, and have been tracking the cohort since. Participants have been re-contacted through questionnaires or assessment in 2003, 2007 & 2010.",BWHHS,"The British Women's Heart and Health Study is a prospective cohort study of heart disease in over 4000 British women between the ages of 60 and 79. BWHHS recruited 4,286 participants.",1991,"0 to 4,999","Professor Juan CasasProfessor Debbie Lawlor","www.ucl.ac.uk/british-womens-heart-health-study","julie.a.taylor@ucl.ac.uk PI Email: jp.casas@ucl.ac.uk; d.a.lawlor@bristol.ac.uk","Tel: +44 (0) 203 549 5064","British Women's Heart and Health Study (c/o Julie Taylor)
Institute of Health Informatics
UCL
222 Euston Road,
London
NW1 2DA","British Heart Foundation",1991,"2,949",60-79,,"Alzheimer's disease|Dementia (unclassified)|Frontotemporal dementia|Lewy body disease|Other NDs not listed|Parkinson's disease|Vascular dementia",,"No diagnosis","United Kingdom",,"0 to 4,999","60 to 100",,"Individual physiological","Blood pressure|Height|Hip circumference|Waist circumference|Weight","Cardiovascular|Hearing and Vision|Musculoskeletal|Reproductive|Respiratory",,,,,"Alcohol|Dietary habits|Physical activity|Smoking","Education|Ethnic group|Family circumstances|Housing and accommodation|Income and finances|Informal support|Marital status|Occupation and employment|Unpaid care",,"University College, London",
"Cambridge Centre for Ageing and Neuroscience","The aim of the Cambridge Centre for Ageing and Neuroscience (Cam-CAN) project is to identify the neural mechanisms underpinning successful cognitive ageing. The study recruitment participants over 18 from resident within Cambridge City and used epidemiological, behavioural, and neuroimaging data to understand how individuals can best retain cognitive abilities into old age. A major aim of the research programme is to understand the nature of brain-cognition relationships across the lifespan, and to highlight the importance of abilities that are maintained into old age.
This population study was not designed to have repeated measures for each participant, but rather as one extended and comprehensive study visit that took place over 3 stages.",CamCan,"The aim of the Cambridge Centre for Ageing and Neuroscience (Cam-CAN) project is to identify the neural mechanisms underpinning successful cognitive ageing. CamCan recruited 3000 participants.",2010,"0 to 4,999","Professor Lorraine Tyler","http://www.cam-can.com","lktyler@csl.psychol.cam.ac.uk","Tel: +44 (0) 1223766457","Professor Lorraine Tyler
Professor of Cognitive Neuroscience,
Department of Psychology,
University of Cambridge,
Cambridge
CB2 3EB,
UK",BBSRC,2010,2500,>18,,"Subjective memory complaints (SMC) or subjective cognitive decline (SCD)",,"No diagnosis","United Kingdom",,"0 to 4,999","10 to 19|20 to 39|40 to 59|60 to 100",,"Individual psychological",Height|Weight,"Cardiovascular|Hearing and Vision",Saliva,,"Magnetic resonance imaging (MRI)|Magnetoencephalography (MEG)",,"Alcohol|Dietary habits|Physical activity|Smoking","Education|Ethnic group|Family circumstances|Housing and accommodation|Income and finances|Informal support|Marital status|Occupation and employment|Unpaid care",,"University of Cambridge",
"Canberra Longitudinal Study","The Canberra Longitudinal Study is a 12 year study into the health and memory of older people which commenced in 1990, with subsequent waves in 1994, 1998 and 2002. The 2002 wave was the last time that participants were approached for interviews - the youngest participant in 2002 was 82 years of age.",,"The Canberra Longitudinal Study is a 12 year study into the health and memory of older people which commenced in 1990 with 1045 participants, with subsequent waves in 1994, 1998 and 2002.",1990,"0 to 4,999","Dr Phil Batterham","https://rsph.anu.edu.au/research/projects/canberra-longitudinal-study","philip.batterham@anu.edu.au",,"Centre for Mental Health
Research, The Australian National University, Canberra, Australian Capital
Territory, Australia",NHMRC,1990,,?70,,"Dementia (unclassified)|Parkinson's disease",,"No diagnosis",Australia,,"0 to 4,999","60 to 100",,"Individual physiological|Individual psychological",Weight,"Cardiovascular|Hearing and Vision|Musculoskeletal|Respiratory",Other,,,,"Alcohol|Dietary habits|Physical activity|Smoking","Education|Ethnic group|Family circumstances|Income and finances|Informal support|Marital status|Occupation and employment|Unpaid care","Formal health and social care service utilisation including private care","Australian National University",
"Costa Rican Longevity and Healthy Aging Study","The Costa Rican Longevity and Healthy Aging Study (CRELES) is a nationally representative longitudinal survey of health and lifecourse experiences of 2,827 Costa Ricans ages 60 and over in 2005. Baseline household interviews were conducted between November 2004 and September 2006, with 2-year follow-up interviews.
The main study objective was to determine the length and quality of life, and its contributing factors in the elderly of Costa Rica.
CRELES uses public data files containing information on a broad range of topics including self-reported physical health, psychological health, living conditions, health behaviours, health care utilization, social support, and socioeconomic status. Objective health indicators include anthropometrics, observed mobility, and biomarkers from fasting blood and overnight urine. Mortality events are tracked and conditions surrounding death are measured in a surviving family interview (longitudinal follow-up data are not yet publicly available).",CRELES,"The Costa Rican Longevity and Healthy Aging Study (CRELES) is a nationally representative longitudinal survey of health and lifecourse experiences of 2,827 Costa Ricans ages 60 and over in 2005.",2006,"0 to 4,999","Dr Luis Rosero-Bixby","http://www.creles.berkeley.edu/","creles@ccp.ucr.ac.cr PI Email: lrosero@ccp.ucr.ac.cr; wdow@berkeley.edu",,"Centro Centroamericano de Población
Universidad de Costa Rica
San José 2060, Costa Rica.","Wellcome Trust",2006,"1,550",>60,,,,"No diagnosis","Costa Rica",,"0 to 4,999","60 to 100",,"Individual physiological|Individual psychological","Blood pressure|Height|Hip circumference|Waist circumference|Weight","Cardiovascular|Hearing and Vision|Musculoskeletal|Reproductive|Respiratory",Blood|Urine,,,,"Alcohol|Dietary habits|Physical activity|Smoking","Education|Ethnic group|Family circumstances|Housing and accommodation|Income and finances|Informal support|Marital status|Occupation and employment",,"University of Costa Rica",
"Project Cygnus","This is a feasibility study which has a Longitudinal Cohort design, following up participants at selected time points over a 1 year duration. The study will recruit 2 distinct groups: (1) patients with symptoms of cognitive impairment, and (2) study partners who are cognitively normal. The patients recruited to group 1 will have been recently referred to a Memory Assessment Service by their GP with suspected Mild Cognitive Impairment (MCI) & mild dementia. All patients referred to a Memory Assessment Service for this reason will be potentially eligible for inclusion in the study. Close friends or family members involved in looking after the cognitively impaired participants will also be asked to participate as study partners to attempt to measure the impact that looking after a partner, friend or family member with memory problems can have on a carers Quality of Life and other variables such as financial burden. Both cognitively impaired participants and their study partners will be given the option of additionally participating in two sub-studies:
 Mobile data collection: Using a web/mobile app to collect self-reported data on a more regular basis from home
 Wearable device: Using a wearable device that looks like a watch to collect information on activity and sleep",CYGNUS,"To understand the patient and care-giver journeys from the initial memory assessments through the early period of treatment and care, the CYNGUS study will collect clinical data and self-reported outcomes from 500 people with memory loss and their supportive partners for one year.","1st April 2016 - 30th September 2017","0 to 4,999","Dr Iracema Leroi",http://www.ecygnus.com/,"Email: francine.jury@manchester.ac.uk
PI Email: iracema.leroi@manchester.ac.uk","Tel: +44 (0)161 275 1623","Project Cygnus
Genomics Research
Stopford Building
Oxford Road
Manchester
M13 9PT","Innovate UK","1st April 2016 - 30th September 2017",389,>18,,"Alzheimer's disease|Dementia (unclassified)|Frontotemporal dementia|Lewy body disease|Mild cognitive impairment (MCI)|Other NDs not listed|Parkinson's disease|Subjective memory complaints (SMC) or subjective cognitive decline (SCD)|Vascular dementia",,"At-risk diagnosis","United Kingdom",,"0 to 4,999","10 to 19|20 to 39|40 to 59|60 to 100",,"Caregiver|Individual physiological|Individual psychological",Height|Weight,"Cardiovascular|Hearing and Vision|Respiratory",,,,,"Alcohol|Physical activity|Smoking","Education|Ethnic group|Family circumstances|Housing and accommodation|Income and finances|Informal support|Marital status|Occupation and employment|Unpaid care","Formal health and social care service utilisation including private care","IXICO PLC., University of Manchester, Northern Health Science Alliance Network (NHSA)",
"Etude Santé Psychologique Prévalence Risques et Traitement/ The ESPRIT Project","For the Esprit study, 1863 non-institutionalized persons aged 65 years and over were randomly recruited in 1999 from the Montpellier district electoral rolls, and re-examined 6-times at 2-3 yearly intervals. Objectives:
1) To determine current and lifetime prevalence as well as incidence of psychiatric disorder in the elderly;
2) to determine the risk factors for these disorders, their relative weight and interactions;
3) to study clinical heterogeneity;
4) to estimate the probability of transition towards a subsyndromic state or a given pathology;
5) to elaborate predictive etiological models.",ESPRIT,"For the Esprit study, 1863 non-institutionalized persons aged 65 years and over were randomly recruited in 1999 from the Montpellier district electoral rolls. ESPIRIT recruited 1863 participants.",1999-2001,"0 to 4,999","Marie-Laure Ancelin and Karen Ritchie","https://hal.archives-ouvertes.fr/inserm-00138456/","PI email: marie-laure.ancelin@inserm.fr; PI email: karen.ritchie@inserm.fr","Tel: +33 4 99 61 45 62","Inserm U1061, Montpellier, France","Novartis, Agence Nationale de la Recherche, Regional government of Languedoc Roussillon, Inserm",1999-2001,926,"65 and over",,"Alzheimer's disease|Dementia (unclassified)|Mild cognitive impairment (MCI)|Parkinson's disease|Subjective memory complaints (SMC) or subjective cognitive decline (SCD)|Vascular dementia",,"No diagnosis",France,,"0 to 4,999","60 to 100",,"Individual psychological","Blood pressure|Height|Hip circumference|Waist circumference|Weight","Cardiovascular|Hearing and Vision|Reproductive|Respiratory",Blood|Other|Saliva,"Gene screening","Magnetic resonance imaging (MRI)|Magnetoencephalography (MEG)",,"Alcohol|Dietary habits|Physical activity|Smoking","Education|Ethnic group|Family circumstances|Housing and accommodation|Income and finances|Marital status|Occupation and employment","Formal health and social care service utilisation including private care","Novartis, Agence Nationale de la Recherche, Regional government of Languedoc Roussillon, Inserm",
"Evergreen Project","The purpose of this project is to describe changes in health and functioning among older people. Living conditions and life-style are studied as predictors of health, functioning, need of care and mortality. This multidisciplinary study includes several prospective arms. In 1988 a random sample of people aged 65-84 years were interviewed in their homes. Follow up interviews for them were conducted in 1996 and 2004. During the same years 65-69 year old people were interviewed to capture cohort changes in aging. In 1989 all men born before 1924 and every other woman living in nursing home were interviewed. In 1989 all 75-year-old and 1990 all 80-year-old residents of Jyväskylä were studied in the laboratory with extensive functional testing and clinical examinations. The 75-year-old people were followed up after 5, 10 and 15 years and the 80-year-olds after 5 and 10 years. In addition, register-based data on hospital and long-term care is being updated until the entire cohort becomes extinct. Altogether, 2500 have participated in these studies.",,"The purpose of this project is to describe changes in health and functioning among older residents of Jyväskylä. The Evergreen Project had 2,500 participants.",1988-1990,,"Emeritus Prof Eino HeIkkinen (1988-2004),Professor Taina Rantanen and Professor Sarianna Sipilä","http://www.gerec.fi/en/research/health-functioning-and-longevity/evergreen-project","PI Email: eino.heikkinen@jyu.fi; taina.rantanen@jyu.fi; sarianna.sipila@jyu.fi",,,"Gerontology Research Center
University of Jyväskylä
Jyväskylä
Finland",1988-1990,,65-94,,,,"No diagnosis",Finland,,"0 to 4,999","60 to 100",,"Individual physiological|Individual psychological","Blood pressure|Height|Waist circumference|Weight","Cardiovascular|Hearing and Vision|Musculoskeletal|Respiratory",Blood,,,,"Alcohol|Dietary habits|Physical activity|Smoking","Education|Ethnic group|Family circumstances|Housing and accommodation|Income and finances|Marital status","Formal health and social care service utilisation including private care","The Social Insurance Institution of Finland, The Ministry of Education, Academy of Finland, City of Jyväskylä, The Association of Finnish Lions Clubs, University of Jyväskylä",
"Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Dementia","The main objective of the FINGER study is to find out if a multi-domain intervention could prevent cognitive decline among older people. With this intervention we also aim to investigate the effect of the multidomain intervention on disability, quality of life, depressive symptoms, the use of health care services and vascular risk factors.
Participants of the FINGER study have previously taken part in population-based non-intervention studies. They have an increased risk of cognitive decline. At the beginning of the study they are 60-77 years old. The FINGER study enrols approximately 1200 participants in six centers in Finland: Helsinki, Kuopio, Oulu, Seinäjoki, Turku and Vantaa.",FINGER,"The objective of the FINGER study is to find out if a multi-domain intervention could prevent cognitive decline among older people.The study enrols approximately 1200 participants in six centers in Finland.",2009-2011,,"Professor Miia Kivipelto","https://www.thl.fi/en/web/thlfi-en/research-and-expertwork/projects-and-programmes/finger-research-project","Coordinator email: Tiia.ngandu@thl.fi; Jenni.lehtisalo@thl.fi PI email: miia.kivipelto@ki.se","Tel.: +46-73-99-409-22","National Institute for Health and Welfare (THL)
Public Health Promotion Unit
P.O. Box 30, FI-00271 Helsinki;
Alzheimers Disease Research Center,
Karolinska Institutet,
Stockholm,
Sweden","Academy of Finland
Novo Nordisk Fonden
Alzheimer's Association
Alzheimer's Research and Prevention Foundation
The Social Insurance Institution of Finland
La Carita Foundation
Juho Vainio Foundation
Swedish Research Council
The Diabetes Research Foundation
Ministry of Education and Culture
Vetenskapsrådet",2009-2011,,60-77,,"Alzheimer's disease|Dementia (unclassified)|Subjective memory complaints (SMC) or subjective cognitive decline (SCD)|Vascular dementia",,"No diagnosis",Finland,,"0 to 4,999","60 to 100",,"Individual physiological|Individual psychological","Blood pressure|Height|Hip circumference|Waist circumference|Weight",Cardiovascular,Blood,,"Magnetic resonance imaging (MRI)|Positron emission tomography (PET) - amyloid|Positron emission tomography (PET) fluorine18 flurodeoxyglucose (FDG)",,"Alcohol|Dietary habits|Physical activity|Smoking","Education|Family circumstances|Housing and accommodation|Income and finances|Informal support|Marital status|Occupation and employment|Unpaid care","Formal health and social care service utilisation including private care","National Institute for Health and Welfare, Universities of Helsinki, Eastern Finland and Oulu, Finland and Karolinska Institutet, Sweden",
"Health Study for England","The Health Survey for England series was designed to monitor trends in the nations health, to estimate the proportion of people in England who have specified health conditions, and to estimate the prevalence of risk factors associated with these conditions. The surveys provide regular information that cannot be obtained from other sources on a range of aspects concerning the publics health. The surveys have been carried out since 1994 by the Joint Health Surveys Unit of NatCen Social Research and the Research Department of Epidemiology and Public Health at UCL. Individuals are asked for written consent to link their HSE records to mortality and cancer registration data (from HSE 1994 onwards) and to Hospital Episodes Statistics (from HSE 2003 participants onwards).
Each survey in the series includes core questions and measurements (such as blood pressure, height and weight, and analysis of blood and saliva samples), as well as modules of questions on topics that vary from year to year. New topics in 2014 year included hearing and mental health. The achieved sample for the 2014 survey was 8,077 adults (aged 16 and over) and 2,003 children (aged 0-15).",HSE,"The Health Survey for England series was designed to monitor trends in the nations health.","1991 onwards",,"Professor Jennifer Mindell (UCL) and Anne Conolly (NatCen)",http://www.ucl.ac.uk/hssrg/studies/hse,"PI email: Anne.Conolly@natcen.ac.uk; j.mindell@ucl.ac.uk","Tel: +44 (0) 20 7250 1866; +44 (0) 20 7679 1269","HSSRG, Research Dept Epidemiology & Public Health
1-19 Torrington Place
London
WC1E 6BT","NHS Digital","1991 onwards",,>0,,,,"No diagnosis","United Kingdom",,"50,000 to 99,999","0 to 9|10 to 19|20 to 39|40 to 59|60 to 100",,"Individual physiological|Individual psychological","Blood pressure|Height|Hip circumference|Waist circumference|Weight","Hearing and Vision|Respiratory",Blood|Saliva|Urine,,,,"Alcohol|Dietary habits|Physical activity|Smoking","Education|Ethnic group|Family circumstances|Housing and accommodation|Income and finances|Marital status|Occupation and employment|Unpaid care","Formal health and social care service utilisation including private care","UCL (University College London) and NatCen Social Research",
"Interdisciplinary Longitudinal Study of Adult Development and Aging","ILSE is an interdisciplinary longitudinal study that offers the opportunity to analyze inter- and intra-individual differences and changes over the life-span as well as relations between environmental factors, behavioral aspects, life-events, health behaviors, mental and physical health and well-being. The bio-graphical approach pursued by the ILSE-study is based on the assumption that the quality of developmental experiences in early life-phases influence the performance and possibilities of adaptation in later life in a unique way.
At the first measurement point, the ILSE sample consisted of 1390 persons from East (re-search centres: Leipzig and Rostock) and West Germany (research centres: Heidelberg, Bonn and Erlangen-Nuremberg). Stratified by sex and cohort membership (born 1930-32 and 1950-52, respectively) the representative ILSE-sample was examined by a interdisciplinary research team. The first round of data collection was conducted between 1993 and 1996, the second round with n = 994 participants from the data collection centres Heidelberg, Leipzig und Rostock (return rate = 90%) was conducted between 1997 and 2000. The third round of data collection which started in January 2005 ended in 2007. A fourth wave was conducted and completed between 2014 and 2016",ILSE,"ILSE is an interdisciplinary longitudinal study that offers the opportunity to analyze inter- and intra-individual differences and changes over life-span. The ILSE sample consisted of 1390 persons from East and West Germany.",1993-1996,"0 to 4,999","Hans-Werner Wahl & Johannes Schröder",http://www.psychologie.uni-heidelberg.de/ae/apa/research/ilse.html,"PI email: h.w.wahl@psychologie.uni-heidelberg.de; johannes.schroeder@med.uni-heidelberg.de
Email: jelena.siebert@psychologie.uni-heidelberg.de",,"Abteilung für Psychologische Alternsforschung
Psychologisches Institut der Universität Heidelberg
Bergheimer Str. 20
69115 Heidelberg","Dietmar Hopp Foundation (since 2013)
Bundesministerium für Familie, Senioren, Frauen und Jugend (BMFSFJ)",1993-1996,560,>40,,"Alzheimer's disease|Mild cognitive impairment (MCI)",,"No diagnosis",Germany,,"0 to 4,999","40 to 59|60 to 100",,"Individual psychological",,"Hearing and Vision",,,,,,"Education|Family circumstances|Housing and accommodation|Income and finances|Informal support|Marital status|Occupation and employment",,"Universität Heidelberg",
"Internet-based Students HeAlth Research Enterprise","i-Share (Internet-based Students HeAlth Research Enterprise) is a new open and prospective cohort on university students' health. Participants are registered in the first years of study initially with the Universities of Bordeaux and Versailles-Saint-Quentin many many other French universities are now participating. Students are followed up with yearly assessments.
The study sets 2 main types of objectives:
1. Evaluate the frequency and impact of several diseases that may have immediate or short-term consequences on health and well-being (e.g. stress and depression, migraine, sexually transmitted infectious diseases, etc.).
2. Biomedical research objectives on the determinants of diseases. We have set up a cerebral MRI study and biobank on a sample of about 2000 participants including DNA and RNA.",I-Share,"I-Share is a new open and prospective cohort on university students' health. I-Share has recruited 2000 participants.",2013-2018,,"Christophe Tzourio and Didier Guillemot",http://www.i-share.fr/,"contact@i-share.fr; PI Email: christophe.tzourio@u-bordeaux.fr; didier.guillemot@pasteur.fr",,"Bordeaux Population Health research center (INSERM U1219)
University of Bordeaux
146, rue Léo Saignat
33076 Bordeaux cedex","National Research Agency for Investments for the Future
European Research Council
Ministry of Health (PHRC)",2013-2018,"18,800",>18,,,,"No diagnosis",France,,,"10 to 19|20 to 39|40 to 59|60 to 100",,"Individual psychological","Blood pressure|Height|Weight",,,,"Magnetic resonance imaging (MRI)",,"Alcohol|Dietary habits|Physical activity|Smoking",,,"University of Bordeaux",
"Longitudinal Study of Cognitive Change in Normal Healthy Old Age","The longitudinal Study of Cognitive Change in Normal Healthy Old Age (LSCC) is a population study including 6,342 healthy residence of Greater Manchester and Newcastle-upon-Tyne aged from 42 to 92 in 1983. Two different batteries of cognitive tests were alternately administered biennially with additional questionnaires and Dna sample collection until 2003. The aims of the study were to:
 to determine sources of variations in rates of cognitive change between individuals
 to identify factors that slow or accelerate cognitive ageing and that prolong mental productivity or accelerate decline
 to generate and test functional models for the processes of biological ageing, especially of ageing of the brain and the central nervous system
 to test whether the neurophysiological and consequent cognitive changes differ in idiosyncratic patterns between individuals",LSCC,"The longitudinal Study of Cognitive Change in Normal Healthy Old Age (LSCC) is a population study including 6,342 healthy residence of Greater Manchester and Newcastle-upon-Tyne aged from 42 to 92 in 1983.",1983,,"Patrick Rabbitt",http://www.tandfonline.com/doi/abs/10.1080/13825580490511116,patrick.rabbitt@psy.ox.ac.uk,,"University of Manchester
Age and Cognitive Performance Research Centre
Oxford Road
Manchester
M13 9PL
UK","U.K. Social Science Research Council (1983 to 1988), Medical Research Council (MRC), Economic and Social Research Council (ESRC)",1983,,46-92,,"Alzheimer's disease|Mild cognitive impairment (MCI)",,"No diagnosis","United Kingdom",,"5,000 to 9,999","40 to 59|60 to 100",,"Individual physiological|Individual psychological",,,Blood|Saliva|Urine,,"Magnetic resonance imaging (MRI)",,"Alcohol|Dietary habits|Physical activity|Smoking","Education|Ethnic group|Family circumstances|Housing and accommodation|Informal support|Marital status|Occupation and employment",,"University of Manchester",
"Maastricht Aging Study","The Maastricht Aging Study (MAAS) was designed to specify the usual and pathological aging of cognitive function. MAAS is devoted to the age-related decline of memory and other cognitive functions in normal people and the factors that may be involved in this process. What determines a decline in memory function? Why do some individuals show a greater decline than others? Over the past years, a host of factors, including biological, medical, psychological and social variables, have been proposed to have an impact on adult cognitive development. MAAS tries to study these factors in an integrative way. This can be achieved only by studying large numbers of normal healthy adults of all ages and by monitoring them for several years.",MAAS,"The Maastricht Aging Study (MAAS) was designed to specify the usual and pathological aging of cognitive function. MAAS has recruited 1,823 participants.",1991,"0 to 4,999","Martin van Boxtel and Sebastian Köhler",http://maastrichtagingstudy.nl,"martin.vanboxtel@maastrichtuniversity.nl; s.koehler@maastrichtuniversity.nl","Tel: 043 - 387 66 00","Department of Psychiatry & Neuropsychology
Faculty of Health, Medicine & Life Sciences
Maastricht University [DRT10]
P.O. Box 616
6200 MD Maastricht
The Netherlands","Maastricht University Medical Centre, The Netherlands Programme for Research on Aging (NESTOR)",1991,"1,823",24-81,,"Alzheimer's disease|Mild cognitive impairment (MCI)|Subjective memory complaints (SMC) or subjective cognitive decline (SCD)|Vascular dementia",,"No diagnosis",Netherlands,,"0 to 4,999","20 to 39|60 to 100",,"Individual psychological","Blood pressure|Height|Hip circumference|Waist circumference|Weight","Cardiovascular|Hearing and Vision|Musculoskeletal|Respiratory",Blood,,"Magnetic resonance imaging (MRI)",,"Alcohol|Dietary habits|Physical activity|Smoking","Education|Income and employment|Marital status|Occupation and employment","Formal health and social care service utilisation including private care","Maastricht University",
"LRRK2 Cohort Consortium","The LRRK2 Cohort Consortium (LCC) comprises three closed studies: the LRRK2 Cross-sectional Study, LRRK2 Longitudinal Study and the 23andMe Blood Collection Study. The LCC followed standardized data acquisition protocols, and clinical data and biological samples are stored in a comprehensive Parkinson's database and biorepository, respectively. A total of 1,213 Idiopathic PD subjects, 1,168 PD subjects with genetic mutations in LRRK2, 1,123 unaffected subjects with genetic mutations in LRRK2, and 779 Healthy Controls (HC) were recruited.",LCC,"The LRRK2 Cohort Consortium (LCC) comprises three closed studies: the LRRK2 Cross-sectional Study, LRRK2 Longitudinal Study and the 23andMe Blood Collection Study. 1,213 Idiopathic PD subjects, 1,168 PD subjects with genetic mutations in LRRK2, 1,123 unaffected subjects with genetic mutations in LRRK2, and 779 Healthy Controls (HC) were recruited.",2011-2015,,,https://www.michaeljfox.org/page.html?lrrk2-cohort-consortium&navid=lrrk2-cohort-consortium,resources@michaeljfox.org,212-509-0995,,"The Michael J. Fox Foundation for Parkinsons Research",2011-2015,,,,"Parkinson's disease",,"At-risk diagnosis|Condition diagnosed|No diagnosis",Canada|China|France|Germany|Israel|Norway|Spain|Tunisia|USA,,"0 to 4,999",,,"Individual physiological|Individual psychological","Blood pressure",Cardiovascular|Musculoskeletal|Reproductive|Respiratory,"Blood|Cerebral spinal fluid (CSF)|Other|Urine","Gene screening","Magnetic resonance imaging (MRI)|Positron emission tomography (PET) fluorine18 flurodeoxyglucose (FDG)|Single photon emission computerised tomography (SPECT)",,"Alcohol|Dietary habits|Physical activity|Smoking","Education|Ethnic group|Family circumstances",,"The Michael J. Fox Foundation for Parkinson's Research",
"Parkinson’s Progression Markers Initiative","The Parkinson's Progression Marker Initiative (PPMI) is an observational, international study designed to establish biomarker defined cohorts and identify clinical, imaging, genetic and biospecimen Parkinson's disease (PD) progression markers to accelerate disease modifying therapeutic trials. A total of 423 untreated PD, 196 Healthy Control (HC), 64 SWEDD (scans without evidence of dopaminergic deficit) subjects, and 65 Prodromal subjects (individuals with hyposmia or REM Sleep Behavior Disorder) were enrolled. PPMI is actively enrolling affected and unaffected individuals with genetic mutations in LRRK2, GBA, or SNCA through the end of 2018. For the most up to date enrollment numbers, please visit http://www.ppmi-info.org/study-design/study-cohorts/. To enroll PD subjects as early as possible following diagnosis, subjects were eligible with only asymmetric bradykinesia or tremor plus a dopamine transporter (DAT) binding deficit on SPECT imaging. Acquisition of data was standardized as detailed at www.ppmi-info.org.",PPMI,"The Parkinson's Progression Marker Initiative (PPMI) is an observational, international study designed to establish biomarker defined cohorts and identify clinical, imaging, genetic and biospecimen Parkinson's disease (PD) progression markers to accelerate disease modifying therapeutic trials.","2010 - present",,"Ken Marek, MD",http://www.ppmi-info.org/,ppmi@michaeljfox.org,212-509-0995,"Institute for Neurodegenerative Disorders","The Michael J. Fox Foundation for Parkinson's Research, Abbvie, Allergan, Avid Radiopharmaceuticals, Biogen, BioLegend, Bristol-Myers Squibb, GE Healthcare, Genentech, GlaxoSmithKline, Lilly, Lundbeck, Merck, Meso Scale Discovery, Pfizer, Piramal, Roche, Sanofi Genzyme, Servier, Takeda, Teva, UCB, and Golub Capital","2010 - present",,,,"Parkinson's disease",,"At-risk diagnosis|Condition diagnosed|No diagnosis","Australia|Austria|France|Germany|Greece|Israel|Italy|Norway|Spain|United Kingdom|USA",,"0 to 4,999",,,"Individual physiological|Individual psychological","Blood pressure|Height|Weight","Cardiovascular|Hearing and Vision|Musculoskeletal|Reproductive|Respiratory","Blood|Cerebral spinal fluid (CSF)|Other|Urine","Gene screening","Magnetic resonance imaging (MRI)|Single photon emission computerised tomography (SPECT)",,"Alcohol|Dietary habits|Physical activity|Smoking","Education|Ethnic group|Family circumstances",,"Institute for Neurodegenerative Disorders",
"Northern Ireland Cohort Longitudinal Study of Ageing","The Northern Ireland Cohort for the Longitudinal Study of Ageing (NICOLA) is a large-scale, public health study involving a representative sample of men and women aged 50 years and over living in Northern Ireland.
The primary objective of NICOLA is to collect longitudinal multidisciplinary data across a wide range of domains to be used for investigation and research relevant to ageing and making Northern Ireland a better place to grow old in.
NICOLA collects extensive information on all aspects of health, social and economic circumstances of ~8500 men and women as they grow older in Northern Ireland over a series of data collection waves approximately every 2-3 years.
Longer term research goals will investigate the determinants of retirement behaviour and economic wellbeing, the impact of cognitive function and sensory disability on decision making, the determinants of disability trajectories, the influence of social participation on these and the interaction of genetic, biological and psychosocial determinants on health and mortality.
There has been one sweep of data collection (2013  2016) and a second is currently underway (2017 - )",NICOLA,"The Northern Ireland Cohort for the Longitudinal Study of Ageing (NICOLA) is a large-scale, public health study involving a representative sample of men and women aged 50 years and over living in Northern Ireland. NICOLA has recruited 8, 504 participants.","2013 - present","5,000 to 9,999","Frank Kee",http://nicola.qub.ac.uk/,nicola@qub.ac.uk,2890978926,"NICOLA study
Centre for Public Health
Queens University Belfast
Institute of Clinical Sciences Block B
Grosvenor Road
Belfast, BT12 6BJ","Atlantic Philanthropies
Economic and Social Research Council
HSC R&D
OFMDFM (Northern Ireland Government)
MRC
IPH
COE, NI","2013 - present","8,504",>50,,,,"No diagnosis","United Kingdom",,"5,000 to 9,999","40 to 59|60 to 100",,"Individual psychological","Blood pressure|Height|Hip circumference|Waist circumference|Weight","Cardiovascular|Hearing and Vision|Respiratory",Blood|Urine,"Gene screening",,,"Alcohol|Dietary habits|Physical activity|Smoking","Education|Ethnic group|Family circumstances|Housing and accommodation|Income and finances|Informal support|Marital status|Occupation and employment|Unpaid care",,"Queens University Belfast",
"Northern Ireland Longitudinal Study and the Northern Ireland Mortality Study","The Northern Ireland Longitudinal Study (NILS) is a large-scale, representative data-linkage study created by linking data from the Northern Ireland Health Card Registration system to the 1981, 1991, 2001 and 2011 Census returns and to administrative data from other sources. These include vital events registered with the General Register Office for Northern Ireland (such as births, deaths and marriages) and the Health Card registration system migration events data. The result is a 30 year plus longitudinal data set which is regularly being updated. In addition to this rich resource there is also the potential to link further Heath and Social care data in our distinct linkage projects (DLPs).
Selection into the study is based on birth date (day and month): 104 dates throughout the year were selected and if an individuals date of birth coincided with one of these they were included in the sample. The sample is large - c. 28% of the Northern Ireland population (approximately 500,000 individuals and accounting for approximately 50% of households).
The Northern Ireland Mortality Study (NIMS) is a large-scale data linkage study that links the 1991, 2001 and 2011 Census returns for the whole of the enumerated population (approximately 1.6 million individuals) to subsequently registered mortality data from the General Register Office (GRO). While larger than NILS it is more limited in scope, focusing only on the linkage of mortality data. It allows researchers to focus on more detailed analyses of specific cause of death, some of which may not be possible in NILS because of small numbers in sub-populations and the analysis of less common causes of death (e.g. accidental death). The NIMS dataset is recommended to researchers whose primary interest is in mortality in Northern Ireland. These data are maintained under the same conditions as the NILS and is accessible only under the same constraints.","NILS; NIMS","The Northern Ireland Longitudinal Study (NILS) is a large-scale, representative data-linkage study created by linking data from the Northern Ireland Health Card Registration system to the Census returns. The Northern Ireland Mortality Study (NIMS) is a large-scale data linkage study that links theCensus returns for the whole of the enumerated population to subsequently registered mortality data.","1981, 1991, 2001, 2011","500,000+","Dr Ian Shuttleworth",http://www.qub.ac.uk/research-centres/NILSResearchSupportUnit/,"Email: rsu@nisra.gov.uk
PI Email: I.Shuttleworth@qub.ac.uk","Tel: +44(0) 2890 388488","Colby House
Stranmillis Court
Belfast
BT9 5RR","Northern Ireland Statistics and Research Agency (NISRA)","1981, 1991, 2001, 2011","538,600",>0,,,,"No diagnosis","United Kingdom",,"100,000 to 499,999","0 to 9|10 to 19|20 to 39|40 to 59|60 to 100",,,,,,,,,,"Education|Ethnic group|Family circumstances|Housing and accommodation|Income and finances|Marital status|Occupation and employment","Formal health and social care service utilisation including private care","Queens University Belfast",
"The Vallecas Project – Early detection of Alzheimer’s Disease","The Vallecas Project is developed in the Research Unit of the Alzheimer's Center of the Reina Sofía Foundation by researchers of the CIEN Foundation. Its main objective is to determine a probabilistic algorithm for the identification of individuals at risk of dementia type Alzheimer's disease (AD) in the course of a few years. This algorithm will be based on the combination of sociodemographic, clinical, neurological, neuropsychological, biological (from blood determinations) and neuroimaging (various 3 Tesla magnetic resonance modalities).
The recruitment phase of the Vallecas Project participants was extended from October 2011 to December 2013. Finally, a total of 1,213 volunteers aged between 70 and 85 and of both sexes were initially evaluated. Once included in the study, it is monitored annually for 5 years in order to assess the evolutionary profile of all participants, specifically identifying those who develop cognitive impairment and / or dementia. The cohort is being followed up annually for 4 years after the baseline.",VP-EDAD,"The Vallecas Project's main objective is to determine a probabilistic algorithm for the identification of individuals at risk of dementia type Alzheimer's disease (AD). VP-EDAD has recruited 1,213 participants. ",2011,1169,"Miguel Medina",http://www.fundacioncien.es/proyectos-de-investigacion/proyecto-vallecas,"Info@fundacioncien.es; gerencia@fundacioncien.es",,"Alzheimer center Queen Sofia Foundation (CIEN Foundation)
C / Valderrebollo, 5
Centro Alzheimer Reina Sofía Foundation
Spain","Queen Sofia Foundation; ISCIII",2011-2013,1169,70-85,09/04/2018,"Alzheimer's disease|Dementia (unclassified)|Mild cognitive impairment (MCI)|Subjective memory complaints (SMC) or subjective cognitive decline (SCD)|Vascular dementia",,"At-risk diagnosis",Spain,,"0 to 4,999","60 to 100","Behaviour|Cognitive function|Mental health|Neurological","Individual physiological|Individual psychological","Blood pressure|Height|Hip circumference|Waist circumference|Weight","Cardiovascular|Hearing and Vision",Blood,"Gene screening","Magnetic resonance imaging (MRI)","Consent for brain donation","Alcohol|Dietary habits|Physical activity|Smoking","Education|Ethnic group|Family circumstances|Informal support|Marital status|Occupation and employment","Formal health and social care service utilisation including private care","Alzheimer center Queen Sofia Foundation (CIEN Foundation)",
"Health 2000/2011","The Health 2000 Survey, carried out in 2000-2001 in Finland, was coordinated by the National Institute for Health and Welfare, THL (the former National Public Health Institute) in co-operation with an extensive network of organizations and experts. The aim of the survey was to provide information on major public health problems, their causes and treatment, health service needs and utilization as well as functional and working capacity. The data for the survey were collected in comprehensive health examination including blood sampling, in interviews and in self-administered questionnaires. The nationally representative sample included 8,028 persons aged 30 or over of whom 85% participated in the health examination conducted at 80 areas in the mainland Finland. In addition, 1,894 young adults (18-29 years) were invited to the health interview and fill in the questionnaire. Further, 1,278 people who had taken part in Mini-Finland Health Survey carried out in 1978-1980 were invited to the re-examination.
The follow-up of the Health 2000 Survey, the Health 2011 Survey, was carried out in 2011-2012. All members of the Health 2000 sample (n=8,135), who were living in Finland in 2011 and had not refused requests to be invited to further studies, were invited to the Health 2011 Survey. In 2011, they were at least 29 years of age. A total of 59% of them participated in the health examination conducted at 59 areas in Finland. In addition, a new random sample of young adults (aged 18-28, n=1,994) was taken. A total of 415 of them were invited to the health examination and the rest of them (1,579) received only the postal questionnaire. Further, 920 people who had previously taken part in the Mini-Finland Health Survey and invited to re-examination in 2001 were invited.
The Health 2000/2011 cohort is also continuously followed-up by linkage to Finnish nationwide registers.","Health 2000/2011","The Health 2000 Study was conducted in 2000-2001 and aimed to provide information on Health and Welfare. 9,922 participants over 18 were surveyed. A follow up was conducted in 2011-2012.",2000-2001/2011-2012,,"Professor Seppo Koskinen","https://www.thl.fi/terveys2000","Email: Seppo.Koskinen@thl.fi","Tel. (exchange) +358 29 524 6000","The National Institute for Health and Welfare
PO BOX 30,
FI-00271
HELSINKI","National Institute for Health and Welfare",2000-2001/2011-2012,,>18,,"Alzheimer's disease|Dementia (unclassified)|Parkinson's disease",,"No diagnosis",Finland,,"10,000 to 19,999","10 to 19|20 to 39|40 to 59|60 to 100","Cognitive function|Mental health|Neurological","Individual physiological|Individual psychological","Blood pressure|Height|Hip circumference|Waist circumference|Weight","Cardiovascular|Hearing and Vision|Musculoskeletal|Reproductive|Respiratory",Blood|Saliva|Urine,"Gene screening",,,"Alcohol|Dietary habits|Physical activity|Smoking","Education|Family circumstances|Housing and accommodation|Income and finances|Informal support|Marital status|Occupation and employment|Unpaid care","Formal health and social care service utilisation including private care",Multiple,
"Leiden – Alzheimer Research Nederland","This project comprises of two complementary parts. One part is aimed at the development of innovative diagnostic techniques to detect molecular signatures of AD based on disturbances of amyloid metabolism and glutamate neurotransmission. In this part, the focus is on the two most promising diagnostic approaches in AD: (molecular) imaging techniques and molecular diagnostic tests of CSF. In the second part of this study, techniques for which proof-of-concept has been found in humans are applied in a large group of AD patients. These patients are recruited in an established network of 4 collaborating memory clinics in The Netherlands, which use a standardized diagnostic protocol and share an extensive common database. Furthermore, more mature molecular, structural, and functional imaging and molecular diagnostic CSF techniques as well as the conventional diagnostic work-up will be applied from the start of the study in patients from the same network of memory clinics.",LeARN,"This LeARN project aims to develop new instruments that enable an earlier and more reliable diagnosis of Alzheimer's Disease (AD) during life. 241 participants were recruited in 2008 there were no specified age restrictions.",Oct-08,"0 to 4,999","Professor Dr. F.R.J. Verhey, Professor Dr. M.A van Buchem, Professor Dr. B. van Berckel and Dr. M. Verbeek","http://www.ctmm.nl/en/projecten/neurodegeneratief/learn?set_language=en publication of the protocol: https://bmcneurol.biomedcentral.com/articles/10.1186/1471-2377-12-72","Email: f.verhey@maastrichtuniversity.nl","Tel: +31-43-3874175","P.O. Box 616 6200 MD
Maastricht,
The Netherlands","CTMM, a Dutch public-private partnership for translational research",Oct-08,304,>18,,"Alzheimer's disease|Dementia (unclassified)|Frontotemporal dementia|Lewy body disease|Mild cognitive impairment (MCI)|Subjective memory complaints (SMC) or subjective cognitive decline (SCD)|Vascular dementia",,"Condition diagnosed",Netherlands,,"0 to 4,999","10 to 19|20 to 39|40 to 59|60 to 100","Behaviour|Cognitive function|Mental health|Neurological","Caregiver|Individual psychological","Blood pressure|Height|Weight",Cardiovascular,"Cerebral spinal fluid (CSF)|CSF biomarker data available",,"Magnetic resonance imaging (MRI)|Positron emission tomography (PET) - amyloid|Positron emission tomography (PET) fluorine18 flurodeoxyglucose (FDG)",,Alcohol|Smoking,"Education|Family circumstances|Housing and accommodation|Income and finances|Marital status|Occupation and employment|Unpaid care","Formal health and social care service utilisation including private care","Leiden University Medical Center, Maastricht University Medical Center, Radboud University Nijmegen Medical Center, VU University Medical Center",
"Leipzig Longitudinal Study of the Aged","LEILA75+ is a prospective population-based cohort study on the epidemiology of dementia and other neurodegenerative disorders. The main aims of the study included to determine a) the prevalence and incidence of dementia as well as subtypes of dementia, b) the prevalence and incidence of mild cognitive impairment (MCI) and c) the occurrence of other related conditions, such as subjective cognitive decline (SCD). Likewise, it was aimed at identifying risk factors and groups of high-risk-individuals for the development of dementia, MCI and SCD.
Overall, 1,692 individuals of at least 75 years of age (from private households as well as from institutions) were approached via random selection from the registry office of the city of Leipzig (response rate: 81%). Finally, the LEILA75+ cohort consisted of 1,265 individuals at baseline. Data collection took place at participants homes through structured interviews (incl. socio-demographic variables, a cognitive test battery/SIDAM, functional and psychosocial assessments, medical conditions). If participants were not able to complete assessments, proxy information was gathers from relatives. After baseline assessment in 1997/1998, 5 follow-up waves were conducted every 1.5 years. Additionally, a long-term follow-up was performed 15 years after baseline.
Further study details have been published in:
Riedel-Heller SG, Busse A, Aurich C, Matschinger H, Angermeyer MC. Prevalence of dementia according to DSM-III-R and ICD-10: results of the Leipzig Longitudinal Study of the Aged (LEILA75+) Part 1. British Journal of Psychiatry 2001; 179: 250-254.
Riedel-Heller SG, Busse A, Aurich C, Matschinger H, Angermeyer MC. Incidence of dementia according to DSM-III-R and ICD-10: results of the Leipzig Longitudinal Study of the Aged (LEILA75+), Part 2. British Journal of Psychiatry 2001; 179: 255-260.
Riedel-Heller S, G, Schork A, Matschinger H, Angermeyer M, C, Recruitment Procedures and Their Impact on the Prevalence of Dementia. Neuroepidemiology 2000;19:130-140.",LEILA75+,"LEILA75+ is a prospective population-based cohort study on the epidemiology of dementia and other neurodegenerative disorders. Overall, 1,692 individuals of at least 75 years of age were recruited between 1997-2013.",1997-2013,,"Prof. Steffi G. Riedel-Heller, MPH","http://isap.uniklinikum-leipzig.de","Email: susanne.roehr@medizin.uni-leipzig.de","Tel: +49 (0) 341 97 15410","Dr. Susanne Roehr, M.Sc.
Institute of Social Medicine, Occupational Health and Public Health (ISAP)
Medical Faculty, University of Leipzig
Philipp-Rosenthal-Straße 55
04103 Leipzig
Germany","Bundesministerium für Bildung und Forschung (BMBF/Federal Ministry of Education and Research)",1997-2013,,>75,,"Alzheimer's disease|Dementia (unclassified)|Mild cognitive impairment (MCI)|Parkinson's disease|Subjective memory complaints (SMC) or subjective cognitive decline (SCD)|Vascular dementia",,"No diagnosis",Germany,,"0 to 4,999","60 to 100","Cognitive function|Mental health|Neurological","Individual physiological|Individual psychological","Blood pressure","Cardiovascular|Hearing and Vision",,"Gene screening",,,Alcohol|Smoking,"Education|Ethnic group|Family circumstances|Housing and accommodation|Informal support|Marital status|Occupation and employment","Formal health and social care service utilisation including private care","Institute of Social Medicine, Occupational Medicine and Public Health (ISAP), Medical Faculty, University of Leipzig, Leipzig, Germany",
"LifeLine Children’s Cohort Study","The Lifelines Cohort Study is a large population-based cohort study and biobank that was established as a resource for research on complex interactions between environmental, phenotypic and genomic factors in the development of chronic diseases and healthy ageing. The Lifelines cohort distinguishes a children's cohort (aged 0-18), an adult cohort (aged 18-65) and the elderly cohort (aged 65+). The protocol for these three sub-cohorts is largely the same, but focuses in part on the characteristics of the specific participant groups.
Between 2006 and 2013, inhabitants of the northern part of The Netherlands and their families were invited to participate, thereby contributing to a three-generation design. Follow-up visits are scheduled every 5 years, and in between participants receive follow-up questionnaires. Linkage is being established with medical registries and environmental data. Lifelines contains information on biochemistry, medical history, psychosocial characteristics, lifestyle and more. Genomic data are available including genome-wide genetic data of 15638 participants. Fasting blood and 24-h urine samples are processed on the day of collection and stored at -80 °C in a fully automated storage facility. The aim of Lifelines is to be a resource for the national and international scientific community. Requests for data and biomaterials can be submitted to the Lifelines Research Office (research@lifelines.nl).",,"The Lifelines Cohort Study is a large population-based cohort study and biobank. Between 2006-2013, 15638 participants were recruited into 3 cohorts a children's cohort (aged 0-18), an adult cohort (aged 18-65) and the elderly cohort (aged 65+).",2006-2013,"10,000 to 19,999","Dr Aafje Dotinga","https://www.lifelines.nl/researcher/biobank-lifelines Online catalogue of available data: https://catalogue.lifelines.nl","PI Email: research@lifelines.nl or a.dotinga@lifelines.nl ",,"Lifelines Cohort Study and Biobank,
PO Box 30.001,
9713 BZ Groningen,
The Netherlands","Dutch Government, Organization of Scientific Research NWO, the Northern Netherlands Collaboration of Provinces (SNN), the European fund for regional development, Dutch Ministry of Economic Affairs, Provinces of Groningen and Drenthe, the University of Groningen, and the University Medical Center Groningen.",2006-2013,15000,<18,,,,"No diagnosis",Netherlands,,"10,000 to 19,999","0 to 9|10 to 19","Behaviour|Cognitive function","Individual psychological","Blood pressure|Height|Hip circumference|Waist circumference|Weight","Cardiovascular|Hearing and Vision|Musculoskeletal|Respiratory",Blood|Microbiome|Other|Urine,,,,"Alcohol|Dietary habits|Physical activity|Smoking","Education|Family circumstances|Housing and accommodation|Occupation and employment","Formal health and social care service utilisation including private care","Lifelines Cohort Study and Biobank",
"LifeLine Adult’s Cohort study","The Lifelines Cohort Study is a large population-based cohort study and biobank that was established as a resource for research on complex interactions between environmental, phenotypic and genomic factors in the development of chronic diseases and healthy ageing. The Lifelines cohort distinguishes a children's cohort (aged 0-18), an adult cohort (aged 18-65) and the elderly cohort (aged 65+). The protocol for these three sub-cohorts is largely the same, but focuses in part on the characteristics of the specific participant groups.
Between 2006 and 2013, inhabitants of the northern part of The Netherlands and their families were invited to participate, thereby contributing to a three-generation design. Follow-up visits are scheduled every 5 years, and in between participants receive follow-up questionnaires. Linkage is being established with medical registries and environmental data. Lifelines contains information on biochemistry, medical history, psychosocial characteristics, lifestyle and more. Genomic data are available including genome-wide genetic data of 15638 participants. Fasting blood and 24-h urine samples are processed on the day of collection and stored at -80 °C in a fully automated storage facility. The aim of Lifelines is to be a resource for the national and international scientific community. Requests for data and biomaterials can be submitted to the Lifelines Research Office (research@lifelines.nl).",,"The Lifelines Cohort Study is a large population-based cohort study and biobank. Between 2006-2013, 15638 participants were recruited into 3 cohorts a children's cohort (aged 0-18), an adult cohort (aged 18-65) and the elderly cohort (aged 65+).",2006-2013,"10,000 to 19,999","Dr Aafje Dotinga","https://www.lifelines.nl/researcher/biobank-lifelines Online catalogue of available data: https://catalogue.lifelines.nl","PI Email: research@lifelines.nl or a.dotinga@lifelines.nl",,"Lifelines Cohort Study and Biobank,
PO Box 30.001,
9713 BZ Groningen,
The Netherlands","Dutch Government, Organization of Scientific Research NWO, the Northern Netherlands Collaboration of Provinces (SNN), the European fund for regional development, Dutch Ministry of Economic Affairs, Provinces of Groningen and Drenthe, the University of Groningen, and the University Medical Center Groningen.",2006-2013,140000,18-65,,"Dementia (unclassified)|Other NDs not listed",,"No diagnosis",Netherlands,,"10,000 to 19,999","10 to 19|20 to 39|40 to 59|60 to 100","Behaviour|Cognitive function|Mental health|Neurological","Caregiver|Individual psychological","Blood pressure|Height|Hip circumference|Waist circumference|Weight","Cardiovascular|Hearing and Vision|Musculoskeletal|Reproductive|Respiratory",Blood|Microbiome|Other|Urine,"Gene screening",,,"Alcohol|Dietary habits|Physical activity|Smoking","Education|Ethnic group|Family circumstances|Housing and accommodation|Income and finances|Informal support|Marital status|Occupation and employment|Unpaid care","Formal health and social care service utilisation including private care","Lifelines Cohort Study and Biobank",
"LifeLine Elderly Cohort study","The Lifelines Cohort Study is a large population-based cohort study and biobank that was established as a resource for research on complex interactions between environmental, phenotypic and genomic factors in the development of chronic diseases and healthy ageing. The Lifelines cohort distinguishes a children's cohort (aged 0-18), an adult cohort (aged 18-65) and the elderly cohort (aged 65+). The protocol for these three sub-cohorts is largely the same, but focuses in part on the characteristics of the specific participant groups.
Between 2006 and 2013, inhabitants of the northern part of The Netherlands and their families were invited to participate, thereby contributing to a three-generation design. Follow-up visits are scheduled every 5 years, and in between participants receive follow-up questionnaires. Linkage is being established with medical registries and environmental data. Lifelines contains information on biochemistry, medical history, psychosocial characteristics, lifestyle and more. Genomic data are available including genome-wide genetic data of 15638 participants. Fasting blood and 24-h urine samples are processed on the day of collection and stored at -80 °C in a fully automated storage facility. The aim of Lifelines is to be a resource for the national and international scientific community. Requests for data and biomaterials can be submitted to the Lifelines Research Office (research@lifelines.nl).",,"The Lifelines Cohort Study is a large population-based cohort study and biobank. Between 2006-2013, 15638 participants were recruited into 3 cohorts a children's cohort (aged 0-18), an adult cohort (aged 18-65) and the elderly cohort (aged 65+).",2006-2013,"10,000 to 19,999","Dr Aafje Dotinga","https://www.lifelines.nl/researcher/biobank-lifelines Online catalogue of available data: https://catalogue.lifelines.nl","PI Email: research@lifelines.nl or a.dotinga@lifelines.nl ",,"Lifelines Cohort Study and Biobank,
PO Box 30.001,
9713 BZ Groningen,
The Netherlands","Dutch Government, Organization of Scientific Research NWO, the Northern Netherlands Collaboration of Provinces (SNN), the European fund for regional development, Dutch Ministry of Economic Affairs, Provinces of Groningen and Drenthe, the University of Groningen, and the University Medical Center Groningen.",2006-2013,12000,65-93,,"Dementia (unclassified)|Other NDs not listed",,"No diagnosis",Netherlands,,"10,000 to 19,999","60 to 100",,"Caregiver|Individual psychological","Blood pressure|Height|Hip circumference|Waist circumference|Weight","Cardiovascular|Hearing and Vision|Musculoskeletal|Reproductive|Respiratory",Blood|Microbiome|Other|Urine,"Gene screening",,"Consent for brain donation","Alcohol|Dietary habits|Physical activity|Smoking","Education|Ethnic group|Family circumstances|Housing and accommodation|Income and finances|Informal support|Marital status|Occupation and employment|Unpaid care","Formal health and social care service utilisation including private care","Lifelines Cohort Study and Biobank",
"The Mayo Clinic Study of Aging","The Mayo Clinic Study of Aging was designed to establish a prospective population-based cohort of subjects to study prevalence, incidence and risk factors for MCI and dementia. The study was conducted in Olmsted County, where several factors enhance the feasibility of population-based epidemiologic research. Most residents seek care within the community from essentially 2 providers, the Mayo Clinic and Olmsted Medical Center, along with their affiliated hospitals and medical facilities within the county. Both healthcare providers use a unit medical record which includes all outpatient and inpatient information for each patient. The study began October 1, 2004, and recruitment is ongoing to maintain a sample size of about 3,000 active participants. Participants are randomly selected from the Olmsted County population using a sex and age-stratified sampling scheme. Selected participants are invited to participate; exclusion criteria are persons who are in hospice or terminally ill or demented, but recruitment of persons with dementia began in 2015. Nearly 6,000 participants have been recruited to date. At the onset of the study, only 70-89 year olds were eligible. Recruitment of 50-69 year-olds began in 2012, and recruitment of 30-49 year olds began in 2014. Followup is performed every 15 months for 50 yrs and older; every 30 months if younger than 50 years by face-to-face visits in the Center, in-home, or by phone for a minority who decline either of the two but still would like to participate. Medical records are reviewed is used to identify prevalent and incident medical conditions (e.g. vascular diseases such as diabetes, hypertension) and incident dementia cases among persons lost to follow-up.",,"The Mayo Clinic Study of Aging was designed to establish a prospective population-based cohort of subjects to study prevalence, incidence and risk factors for MCI and dementia. It began in 2004 recruiting 2719 participants.",Oct-04,,"Dr. Ronald Petersen","https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2821441/","PI Email: peter8@mayo.edu",,"Dr. Rosebud O. Roberts The PI is Dr. Ronald Petersen, Department of Neurology,
Division of Epidemiology,
Department of Health Sciences Research,
Mayo Clinic,
200 First Street SW,
Rochester, MN 55905 (USA)","National Institute on Aging
National Institute of Mental Health
National Institute of Arthritis and Musculoskeletal and Skin Diseases, Robert H. and Clarice Smith and Abigail van Buren Alzheimer's Disease Research Program, GHR Foundation",Oct-04,,70-80,,"Alzheimer's disease|Dementia (unclassified)|Frontotemporal dementia|Lewy body disease|Mild cognitive impairment (MCI)|Parkinson's disease|Vascular dementia",,"No diagnosis",USA,,"0 to 4,999","60 to 100","Behaviour|Cognitive function|Mental health|Neurological","Individual physiological|Individual psychological","Blood pressure|Height|Weight","Cardiovascular|Hearing and Vision","Blood|Cerebral spinal fluid (CSF)","Gene screening","Magnetic resonance imaging (MRI)|Positron emission tomography (PET) - amyloid","Consent for brain donation","Alcohol|Dietary habits|Smoking","Education|Ethnic group|Family circumstances|Housing and accommodation|Marital status|Occupation and employment",,"Mayo Clinic",
"Vitality 90+ (Tervaskannot 90+)","The Vitality 90+ Study (in Finnish: Tervaskannot 90+) is a multidisciplinary project focusing on longevity and the oldest-old. The sub-projects address the biological basis of aging, predictors of health, functioning and longevity, old age as an individual experience, and the need for and use of care and services. The research is motivated by the rapid changes in the population structure and by the increase in real longevity.
Data was collected through mailed surveys with whole cohorts of people aged 90+ in Tampere, face-to-face interviews and performance tests and blood samples. The mailed surveys were conducted with all community-dwelling people in 1996 and 1998, and with both community-dwelling and institutionalized people four times since 2001.",,"The Vitality 90+ Study is a multidisciplinary project focusing on longevity and the oldest-old. A survey was sent to those over 90 in 1995 and has been repeated multiple times, the next round will be in 2018.",1995-present,"0 to 4,999","Professor Marja Jylhä","http://www.gerec.fi/en/research/health-functioning-and-longevity/vitality-90","PI email: marja.jylha@uta.fi",,"Gerontology Research Center and School of Health Sciences,
33014 University of Tampere,
Tampere,
Finland","Academy of Finland, Pirkanmaa Hospital District",1995-present,4563,>90,,"Dementia (unclassified)|Parkinson's disease|Subjective memory complaints (SMC) or subjective cognitive decline (SCD)",,"No diagnosis",Finland,,"0 to 4,999","60 to 100","Cognitive function|Mental health|Neurological","Individual physiological|Individual psychological","Height|Hip circumference|Waist circumference|Weight","Cardiovascular|Hearing and Vision|Musculoskeletal",Blood,"Gene screening",,,,"Education|Family circumstances|Housing and accommodation|Informal support|Marital status|Occupation and employment",,"Gerontology Research Center",
CARTaGENE,"The CARTaGENE (CaG) study is both a population-based biobank and the largest ongoing prospective health study of men and women in Quebec. CaG targeted the segment of the population that is most at risk of developing chronic disorders, that is 40-69 years of age, from six census metropolitan areas in Quebec. The sampling was stratified by age, sex and postal groups and is proportional to the density of the population in these areas. Over 43,000 participants consented to visiting 1 of 12 assessment sites where detailed health and socio-demographic information, physiological measures and biological samples (blood, serum and urine) were captured. Participants are followed-up based on linkage to governmental health administrative databases and direct reassessment through a web portal.
Last update 21/09/2017",CaG,"The CAG study is the largest prospective health study in Quebec. Over 43,000 participants over 40-69 were recruited between 2009-2010.",2009-2013|2013-2015,"20,000 to 49,999","Dr Anne-Monique Nuyt and Dr Sebastien Jacquemont","http://www.cartagene.qc.ca/en/home","Email: access@cartagene.qc.ca PI emails: anne-monique.nuyt@recherche-ste-justine.qc.ca and sebastien.jacquemont@umontreal.ca","Tel: 514-343-7703 ext. 6393","CHU Sainte-Justine Research Centre
3333 Queen-Mary, Office 490/493
Montreal
H3V 1A2
Qc, CA","Genome Quebec, CPAC",2009-2013|2013-2015,43000,40-69,,"Alzheimer's disease|Parkinson's disease",,"No diagnosis",Canada,,"20,000 to 49,999","40 to 59|60 to 100","Cognitive function|Mental health|Neurological",,"Blood pressure|Height|Hip circumference|Waist circumference|Weight","Cardiovascular|Hearing and Vision|Musculoskeletal|Reproductive|Respiratory",Blood|Saliva|Urine,"Gene screening","Magnetic resonance imaging (MRI)",,"Alcohol|Dietary habits|Physical activity|Smoking","Education|Ethnic group|Family circumstances|Housing and accommodation|Income and finances|Informal support|Marital status|Occupation and employment|Unpaid care","Formal health and social care service utilisation including private care","CHU Sainte-Justine Research Centre",
"Open Access Series of Imaging Studies","The Open Access Series of Imaging Studies (OASIS) is a project aimed at making MRI data sets of the brain freely available to the scientific community.
OASIS: Cross-sectional MRI Data in Young, Middle Aged, Nondemented and Demented Older Adults
This set consists of a cross-sectional collection of 416 subjects aged 18 to 96. For each subject, 3 or 4 individual T1-weighted MRI scans obtained in single scan sessions are included. The subjects are all right-handed and include both men and women. 100 of the included subjects over the age of 60 have been clinically diagnosed with very mild to moderate Alzheimer's disease (AD). Additionally, a reliability data set is included containing 20 nondemented subjects imaged on a subsequent visit within 90 days of their initial session.
OASIS: Longitudinal MRI Data in Nondemented and Demented Older Adults
This set consists of a longitudinal collection of 150 subjects aged 60 to 96. Each subject was scanned on two or more visits, separated by at least one year for a total of 373 imaging sessions. For each subject, 3 or 4 individual T1-weighted MRI scans obtained in single scan sessions are included. The subjects are all right-handed and include both men and women. 72 of the subjects were characterized as nondemented throughout the study. 64 of the included subjects were characterized as demented at the time of their initial visits and remained so for subsequent scans, including 51 individuals with mild to moderate Alzheimer's disease. Another 14 subjects were characterized as nondemented at the time of their initial visit and were subsequently characterized as demented at a later visit.
Last Update 21/09/2017",Oasis,"The Open Access Series of Imaging Studies (OASIS) is a project aimed at making MRI data sets of the brain freely available to the scientific community. 565 participants are over 18 years currently involved.",,,"Dr. Randy Buckner","http://www.oasis-brains.org/ ","Email: dmarcus@wustl.edu ",,"Dr Daniel Marcus
Washington University School of Medicine
Department of Radiology
Campus Box 8225
4525 Scott Avenue, Suite 3339
St. Louis, MO 63110",,,,>18,,"Dementia (unclassified)",,"Condition diagnosed",USA,,"0 to 4,999","10 to 19|20 to 39|40 to 59|60 to 100","Behaviour|Cognitive function|Mental health|Neurological","Individual physiological|Individual psychological",,,,,"Magnetic resonance imaging (MRI)",,,"Education|Informal support|Unpaid care",,"Washington University Alzheimer's Disease Research Center",
"The Milan Geriatrics 75+ Cohort Study","Current evidence on older adults is derived from population-based cohort studies and randomized controlled trials, which may not include frail individuals. Data are lacking on older outpatients, a potentially diverse population. To bridge the gap between current evidence and clinical practice needs, the Milan Geriatrics 75+ Cohort Study was designed as an observational hospital-based outpatient cohort study. This study included 1861 new consecutive outpatients aged ?75 years who attended a first comprehensive visit at the Geriatric Unit of 'I.R.C.C.S. Ca' Granda' in Milan, Italy, in the period between January 3, 2000 and March 25, 2004. These participants routinely underwent an extensive standardized structured medical examination and comprehensive geriatric assessment with trained physicians. At baseline, data were collected on reason for referral, demographics, physiological anamnesis, past and present medical history and medication use. Moreover, medical examination and anthropometric measurements were performed. Cognitive function was assessed using the 30-item Mini-Mental State Examination (MMSE). Functional status was evaluated using Katz' Activities of Daily Living (ADL) and Lawton' Instrumental Activities of Daily Living (IADL) questionnaires. At 10-year follow-up, all-cause mortality was assessed by collecting data from the Register Office of Milan or other town of residence.
Last Update 21/09/2017","Milan Geriatric 75+","The Milan Geriatric 75+ is an observational study which included 1861 outpatients aged ?75 years who attended the Geriatric Unit of 'I.R.C.C.S. Ca' Granda' in Milan, Italy between January 2000 and March 2004.",2000-2004,,"Professor Daniela Mari / Giulia Ogliari, MD PhD","https://openaccess.leidenuniv.nl/handle/1887/38711 ","Email: giulia.ogliari@virgilio.it ",,,"Universit' degli Studi di Milano",2000-2004,,>75,,"Alzheimer's disease|Dementia (unclassified)|Frontotemporal dementia|Lewy body disease|Mild cognitive impairment (MCI)|Parkinson's disease|Subjective memory complaints (SMC) or subjective cognitive decline (SCD)|Vascular dementia",,"No diagnosis",Italy,,"0 to 4,999","60 to 100","Cognitive function|Mental health|Neurological","Individual psychological","Blood pressure|Height|Weight","Cardiovascular|Hearing and Vision|Musculoskeletal|Respiratory",,,,,Alcohol|Smoking,"Education|Occupation and employment",,"Universit' degli Studi di Milano",
"Longitudinal Urban Cohort Ageing Study","To investigate factors that are relevant to maintain functional competence, to prevent long-term disability and to minimise unnecessary service utilisation among older people. (1) Therefore, periodic assessments are performed covering information on functional status (ROBUST, postROBUST, preFRAIL, FRAIL according tio LUCAS Functional Ability Index; Dapp U et al. BMC Geriatr 2014;14:141.), health behaviour, health care use, the need of long-term care, and survival over a period of more than 10 years. (2) Long-term effects of randomised (RCT) health promotion intervention will be evaluated (Dapp U et al. Draft for Dtsch Arztebl Int 2017; Neumann L et al. J Nutr Health Aging 2017;doi:10.1007/s12603-017-0932-1). There were two approaches (a) small group sessions ﾓActive health promotion in old ageﾔ (Dapp U et al. J Gerontol A Biol Sci Med Sci 2011;66:591-8.), and (b)
home visits (Pr'fener F Z Gerontol Geriatr 2016;49:596-605).
3,326 independently living community-dwelling elderly people (60 years and over) were recruited from 21 general practices in 2000 (baseline). They were followed up over a ten year period until 2010 resulting in multidimensional data sets for every single participant at baseline, 1 year, 7 year and 9 year follow up (Dapp U et al. BMC Geriatr 2012 Jul 9;12:35.).
Last Update 21/09/2017",LUCAS,"LUCAS is a population study focused on 3,326 independently living community-dwelling elderly people (60 years and over). It began in 2000 to investigate factors that are relevant to maintain functional competence.",2000-2001,"20,000 to 49,999","Dr. rer. nat. Ulrike Dapp","https://www.albertinen.de/krankenhaeuser/geriatrische_klinik/leistungsspektrum/lucas/teilprojekt1 ","PI Email: ulrike.dapp@albertinen.de ","(040) 5581-1871","Dr. Ulrike Dapp
Albertine-Haus Hamburg
Department of Geriatric Clinic and Research Department
Albertinen-Haus, Center for Geriatrics and Gerontology
Scientific institution at the University of Hamburg
Sellhopsweg 18-22
22459 Hamburg","German Federal Ministry of Education and Research: LUCAS I: 01ET0708 | LUCAS II: 01ET1002A | LUCAS III/PROLONG HEALTH 01EL1407)
European Commission | HORIZON 2020 | MINDMAP | Research and innovation action no 667661",2000-2001,20000,>60,,,,"No diagnosis",Germany,,"0 to 4,999","60 to 100","Behaviour|Cognitive function|Mental health","Individual physiological|Individual psychological",,,,,,,"Alcohol|Dietary habits|Physical activity|Smoking","Education|Housing and accommodation|Income and finances|Informal support|Marital status","Formal health and social care service utilisation including private care","Department of Geriatric Clinic and Research Department",
"Identifying Predictors of dementia with Lewy bodies in People with Mild Cognitive Impairment","Dementia with Lewy Bodies (DLB) is the second most common cause of neurodegenerative dementia in older people. The aim of LewyPro is to examine and characterise symptoms and brain changes during the prodromal period of LBD. Earlier diagnosis is important because it facilitates care planning, leads to earlier treatment of cognitive symptoms and enables earlier identification of other symptoms, including parkinsonism.
Lewy Pro is recruiting a group of people with mild cognitive impairment (MCI) and prodromal symptoms suggestive of Dementia with Lewy Bodies (DLB) and following them up annually to assess biomarker changes and clinical course. The initial assessment will include a detailed clinical assessment, a blood sample, a lumbar puncture for cerebrospinal fluid, and a DaTSCAN.
Last Update 21/09/2017",LewyPro,"LewyPro is a ND specific cohort which recruited 264 participants over 60 in 2005 with MCI and prodromal symptoms suggestive of Lewy Bodies Disease.",2005,"0 to 4,999","Professor Alan Thomas","https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4729131/ ","PI Email: alan.thomas@ncl.ac.uk ","+44 (0) 231912081322","Biomedical Research Building,
Newcastle University Campus for Ageing and Vitality,
Newcastle upon Tyne,
NE4 5PL","National Institute for Health Research (NIHR)|Newcastle Biomedical Research Unit|National Health Service (NHS)|Foundation Trust, Newcastle University|Alzheimer's Research UK",2005,194,>60,,"Alzheimer's disease|Lewy body disease|Mild cognitive impairment (MCI)|Subjective memory complaints (SMC) or subjective cognitive decline (SCD)",,"Condition diagnosed","United Kingdom",,"0 to 4,999","60 to 100","Behaviour|Cognitive function|Mental health","Individual physiological|Individual psychological","Blood pressure|Height|Weight","Cardiovascular|Hearing and Vision","Blood|Cerebral spinal fluid (CSF)|CSF biomarker data available","Gene screening","Single photon emission computerised tomography (SPECT)","Consent for brain donation",Alcohol|Smoking,"Education|Family circumstances|Housing and accommodation|Income and finances|Informal support|Occupation and employment",,"Newcastle University",
"Generation Scotland: Scottish Family Health Study","The aim of GS: SFHS is to establish a large, family-based intensively-phenotyped cohort recruited from the general population across Scotland, as a resource for studying the genetics of health areas of current and projected public health importance. It aims to identify genetic variants accounting for variation in levels of quantitative traits underlying the major common complex diseases (such as cardiovascular disease, cognitive decline, mental illness) in Scotland.
Baseline data was collected at a single clinic visit. Longitudinal data is available by linkage to NHS medical records. Some participants are being invited to new clinic visits in 2015-17. This profile also includes scanning information from the Stratifying Resilience and Depression Longitudinally (STRADL) study to which approximately 1500 GS participants are being invited for scanning.
Last Update 21/09/2017",GS:SFHS,"GS:SFHS is a longitudinal cohort which recruited 23960 participants over 18 between 2006-2001. It will be used as a resource for studying the genetics of health areas of current and projected public health importance.",2006-2011,,"Professor David Porteous","www.generationscotland.org","info@generationscotland.org PI Email: David.porteous@ed.ac.uk","+44 (0) 1316511040","Medical Genetics Section,
University of Edinburgh,
IGMM,
Western General Hospital,
Crewe Road South,
Edinburgh,
EH4 2XU","Scottish Government Health Directorates",2006-2011,,>18,,"Alzheimer's disease|Dementia (unclassified)|Parkinson's disease",,"No diagnosis","United Kingdom",,"20,000 to 49,999","10 to 19|20 to 39|40 to 59|60 to 100","Behaviour|Cognitive function|Mental health|Neurological",,"Blood pressure|Height|Hip circumference|Waist circumference|Weight",Cardiovascular|Musculoskeletal|Reproductive|Respiratory,Blood|Urine,"Gene screening","Magnetic resonance imaging (MRI)",,"Alcohol|Dietary habits|Physical activity|Smoking","Education|Ethnic group|Family circumstances|Housing and accommodation|Income and finances|Occupation and employment","Formal health and social care service utilisation including private care","Universities of Edinburgh, Aberdeen, Dundee and Glasgow and NHS Scotland",
"Italian Project on the Epidemiology of Alzheimer’s Disease","All people aged 65-84 listed in the population registers of the 12 Italian participating towns as resident and alive on the 31.12.2002. The community based random sample was stratified by gender and 5-year age classes following an equal allocation strategy.
The general objective of IPREA-FU is to improve the evidence base on the preclinical phase of dementia, providing a better insight into its heterogeneous evolution.
Last Update 21/09/2017",IPREA,"IPREA is a population study which began in 2003 recruiting 4,785 65-84 year olds registered in participating towns. The objective of IPREA?FU is to improve the evidence base on the preclinical phase of dementia.",2003,,"Professor Emanuele Scafato","http://www.iss.it/biobankcnesps/index.php?lang=2&id=166&tipo=25","PI email: emanuele.scafato@iss.it","+39 4990 4028","Istituto Superiore Sanit' (ISS) - National Centre for Epidemiology, Surveillance and Health Promotion (CNESPS)
Population Health and Health Determinants Unit
Viale Regina Elena, 299
Rome
00161
Italy","Italian Ministry of Health",2003,,65-84,,"Alzheimer's disease|Other NDs not listed",,"No diagnosis",Italy,,"0 to 4,999","60 to 100","Cognitive function","Individual physiological|Individual psychological","Blood pressure",Cardiovascular,Blood,,"Magnetic resonance imaging (MRI)",,,,"Formal health and social care service utilisation including private care","National Centre for Epidemiology, Surveillance and Health Promotion (CNESPS)",
"Vascular Ageing, Decline in Brain and Cognitive Functions","The EVA study was a 9-year longitudinal study with 6 waves of follow-ups. During the two-year period 1991-1993 (EVA0), 1389 men and women born between 1922 and 1932 were recruited.
The aim is to investigate vascular ageing, decline in brain and cognitive function and associated factors with a longitudinal follow-up study. The secondary objective is to determine to role of biological factors linked with oxidative stress and brain ageing.
Inclusion criteria Subjects from both genders born between 1922 and 1932 (59 to 71 years old at enrolment), included in electoral registers in Nantes, can speak French and living in Nantes.
Last Update 21/09/2017",EVA,"The EVA study was a 9-year longitudinal study with 6 waves of follow-ups. During the two-year period 1991-1993 (EVA0), 1389 men and women born between 1922 and 1932 were recruited.",1991-1993,,"Dr Claudine Berr","https://epidemiologie-france.aviesan.fr/en/content/view/full/84808#tab_1 ","PI Email: claudine.berr@inserm.fr ","+33 (0)4 99 61 45 66",,"MERCK And EISAI",1991-1993,,59-71,,,,"No diagnosis",France,,"0 to 4,999","40 to 59|60 to 100","Cognitive function|Mental health|Neurological","Individual physiological|Individual psychological","Blood pressure|Height|Weight",Cardiovascular,Blood,,,,"Alcohol|Dietary habits|Physical activity|Smoking","Education|Income and finances|Marital status|Occupation and employment","Formal health and social care service utilisation including private care","Institut National de la Sant' et de la Recherche M'dicale",
"The European Alzheimer Disease Consortium Pet Project","The EADC-PET project (EAPP, The European Alzheimer's Disease Consortium PET project) is a spontaneous multicentric study (ProtocolDraftSep2008; ProtocolDraftFeb2009) involving at the moment five Centres in four Countries (CENTRES), belonging to the EADC consortium. It was launched during the EADC meeting in Amsterdam, during fall 2007, by Flavio Nobili (Genoa) who is the Principal Investigator.
The project aims at sharing FDG-PET, MRI, neuropsychological, genetic, EEG and clinical information of patients with amnestic Mild Cognitive Impairment (aMCI) and matched healthy controls. Information is uploaded in a safe FTP facility on the server of University of Genoa. Username and password have been provided to all participants. Use of data is regulated by a 'Confidentiality Disclosure Agreement' that can be downloaded from this web site (Confidential_Disclosure_Agreement). The Centres propose original studies by sending a formal proposal to all participants who can agree or disagree, or propose modifications/suggestions to the original proposal.
The objective is to follow-up aMCI patients with clinical and neuropsychological examinations to pick up conversion to Alzheimer's dementia or to other forms of dementia. FDG-PET can be analyzed by means of several post-processing strategies to highlight glucose metabolic information and to identify the characteristics of what is today called 'prodromal' AD.
Last Update 21/09/2017","(EADC) - (EAPP)","EADC-PET is a multicentric study which was launched in 2007. 142 participants over 18 years of age were recruited with the objective of following MCI patients with clinical and neuropsychological examinations.",2009-2012,,"Flavio Nobili","http://www.eadc.info/sito/pagine/a_07.php?nav=a ","PI Email: flaviomariano.nobili@hsanmartino.it ","+39 010 3537568","Clinical Neurology, Dept of Neuroscience (DINOGMI), Univ of Genoa, Largo Daneo, 3
I-16132 Genoa, Italy",,2009-2012,,>18,,"Alzheimer's disease",,"At-risk diagnosis",France|Germany|Italy|Netherlands,,"0 to 4,999","10 to 19|20 to 39|40 to 59|60 to 100","Cognitive function|Mental health|Neurological","Individual psychological",,,"Cerebral spinal fluid (CSF)|CSF biomarker data available","Gene screening","Magnetic resonance imaging (MRI)|Positron emission tomography (PET) fluorine18 flurodeoxyglucose (FDG)",,,Education,,Multiple,
"Aragon Workers Health Study","AWHS is a prospective, longitudinal cohort study based on the annual health exams of 5,688 workers of the General Motors Spain automobile assembly plant located in Figueruelas (Zaragoza, Spain). The study was designed to evaluate the trajectories of traditional and emergent cardiovascular diseases (CVD) risk factors (overweight, obesity, high blood pressure, diabetes, smoking, dietary habits or sedentary lifestyle), and their association with metabolic abnormalities and the prevalence and progression of subclinical atherosclerosis in a population of middle-aged men and women in Spain.
The specific aims of AWHS are:
1. To establish the research infrastructure required for a longitudinal cohort study, including setting up a biobank of repeated biological samples to conduct future assays in stored serum, plasma, whole blood, urine and DNA.
2. To identify new genetic, behavioural, and environmental determinants of the progression of adiposity and of the development of metabolic abnormalities and cardiovascular risk factors.
3. To characterize the prevalence and progression of subclinical CVD through non-invasive imaging techniques and their genetic, behavioural, and environmental determinants.
4. To interact with external investigators to promote the use of the study database and stored materials for ancillary studies and to disseminate the study findings to the scientific community, to public health authorities, and to the general public.
To collect data, factory workers undergo a standardized annual clinical exam, providing a clinical history, including clinical events and hospitalizations over the past year and current medication use, and undergo a physical exam, consisting of anthropometry (height, weight, and waist circumference), blood pressure measurements and heart rate, as well as laboratory assays, providing biological samples including serum, plasma, blood, urine and DNA. Data collection at the annual medical exams is conducted by the physicians and nurses of the Medical Services of General Motors Spain, who underwent training and standardization programs organized by the study investigators.
Each year, one random third of study participants 40 ﾖ55 years of age at baseline (n=2667) are selected for subclinical atherosclerosis imaging (Cardiac CT for Calcium Scoring, 2D ultrasound of carotid arteries, infrarenal aorta and femoral arteries), and for additional questionnaires of cardiovascular and lifestyle factors (dietary habits, sedentary, physical activity and sleep).
On September 2017, a substudy will begin with the aim of identifying early cognitive impairment in workers over 55 years of age, by using specific questionnaires and gene screening (Apo E).
Workers were excluded from the cohort if they have clinically overt CVD, or a major clinical condition limiting survival to <3 years at baseline. All laboratory procedures have been reviewed and improved to meet the ISO 9001:2008 standard, verified by an external audit.
Last Update 21/09/2017",AWHS,"AWHS is a prospective, longitudinal cohort study based on the annual health exams of 5,688 workers of the General Motors Spain automobile assembly plant. The study recruited participants over 18 between Feb 2009 and Dec 2012.","Feb 2009 - Dec 2012","5,000 to 9,999","Dr. Jos' Antonio Casasnovas","https://ec.europa.eu/eip/ageing/commitments-tracker/a3/aragon-workers-health-study-awhs_en ","PI Email: jacasas@unizar.es ",,"Instituto Aragon's de Ciencias de la Salud (IACS)
Fundaci'n Instituto Investigaci'n Sanitaria de Arag'n (IIS Arag'n)
Avenida San Juan Bosco, n'13, 50009 Zaragoza, Spain","Instituto Aragon's de Ciencias de la Salud (IACS) of the regional Government of Arag'n and The National Center for Cardiovascular Research (CNIC) of the Instituto de Salud Carlos III","Feb 2009 - Dec 2012",5688,>18,,,,"No diagnosis",Spain,,"50,000 to 99,999","10 to 19|20 to 39|40 to 59|60 to 100",,,"Blood pressure|Height|Hip circumference|Waist circumference|Weight",Cardiovascular|Respiratory,Blood|Urine,"Gene screening",,,"Alcohol|Dietary habits|Physical activity|Smoking","Education|Family circumstances|Marital status|Occupation and employment",,"Fundaci'n Instituto Investigaci'n Sanitaria de Arag'n (IIS Arag'n)|Instituto Aragon's de Ciencias de la Salud (IACS)",
"Alberta’s Tomorrow Project","Alberta's Tomorrow Project (ATP) is a longitudinal study tracking the health of 55,000 adults aged 35-69 years in this western Canadian province. ATP was launched in 2000 as a prospective cohort research platform to study the relationship between environmental, lifestyle, and genetic factors and the incidence of cancer and chronic diseases.
In 2008, ATP joined a nation-wide research platform called the Canadian Partnership for Tomorrow Project (CPTP) representing more than 300,000 participants from five provincial cohorts: Alberta, British Columbia, Ontario, Quebec and the Atlantic provinces (Prince Edward Island, New Brunswick, Newfoundland and Labrador, and Nova Scotia). Together, the consortium of five regional studies provides greater statistical power for research, as well as opportunities to examine geographical trends in health and wellbeing across Canada's vast landscape.
The information contained herein is specific to the ATP cohort.
Last Update 21/09/2017",ATP,"ATP is a longitudinal study tracking the health of 55,000 adults aged 35-69 years in this western Canadian province. It began in 2008 and hopes to provide greater statistical power for research.",2000-2015,"50,000 to 99,999","Dr Paula Robson","http://myatp.ca/","Contact email: ATP.Research@ahs.ca PI email: paula.robson@albertahealthservices.ca",,"ATP Research
Alberta Health Services - CancerControl Alberta
Richmond Road Diagnostic & Treatment Centre
1820 Richmond Road SW
Calgary, AB, Canada
T2T 5C7

Access Guidelines http://myatp.ca/for-researchers/access-guidelines-and-procedures ","Funding provided by the Alberta Cancer Prevention Legacy Fund, administered through Alberta Health, the Alberta Cancer Foundation, The Canadian Partnership Against Cancer, and in-kind support provided by Alberta Health Services.",2000-2015,55000,35-69,,,,"No diagnosis",Canada,,"50,000 to 99,999","20 to 39|40 to 59|60 to 100","Mental health|Neurological","Individual psychological","Blood pressure|Height|Hip circumference|Waist circumference|Weight","Cardiovascular|Hearing and Vision|Musculoskeletal|Reproductive|Respiratory",Blood|Saliva|Urine,"Gene screening",,,"Alcohol|Dietary habits|Physical activity|Smoking","Education|Ethnic group|Family circumstances|Housing and accommodation|Income and finances|Informal support|Marital status|Occupation and employment|Unpaid care","Formal health and social care service utilisation including private care","Richmond Road Diagnostic & Treatment Centre",
"Coronary Artery Risk Development in Young Adults","The Coronary Artery Risk Development in (Young) Adults (CARDIA) Study was initiated in 1984 by the National Heart, Lung, and Blood Institute (NHLBI) to assist in providing a better understanding of the
trends and determinants of coronary heart disease (CHD) in the United States (US). The study began by focusing on young adults ? persons 18 to 30 years of age at the time of the Year 0 (Y0) baseline
screening, undertaken between March 1985 and June 1986. A random selection of 5,115 black and white men and women identified by each of the four CARDIA field centres constituted the cohort.
Follow?up examinations at Y2, Y5, Y7, Y10, Y15, Y20, and Y25 achieved high retention, collected a rich set of high quality data and stored specimens bearing on the risk factors and possible causes of cardiovascular disease (CVD).
Last Update 21/09/2017",CARDIA,"CARDIA is a longitudinal study focused on cardiovascular disease in young adults. 5,115 participants aged 18-30 were recruited between 1985-6.",1985-6,,"Dr James M. Shikany","http://www.cardia.dopm.uab.edu/ ",,205-934-0786,"University of Alabama at Birmingham
School of Medicine
Department of Medicine
Division of Preventive Medicine
1717 11th Avenue South, Suite 401
Birmingham, AL 35205","National Heart, Lung, and Blood Institute (NHLBI)",1985-6,,18-30,,,,"No diagnosis",Norway,,"5,000 to 9,999","10 to 19|20 to 39","Behaviour|Cognitive function|Mental health|Neurological","Individual physiological|Individual psychological","Blood pressure|Height|Hip circumference|Waist circumference|Weight",Cardiovascular|Reproductive|Respiratory,Blood|Microbiome|Urine,"Gene screening","Magnetic resonance imaging (MRI)",,"Alcohol|Dietary habits|Physical activity|Smoking","Education|Ethnic group|Family circumstances|Housing and accommodation|Marital status|Occupation and employment","Formal health and social care service utilisation including private care","University of Alabama at Birmingham",
"Sydney Centenarian Study","The Sydney Centenarian Study is an ongoing project that has established a representative cohort of very elderly Australians. It has provided evidence that dementia is not inevitable at this age and that independent living is common. The data collected to date provides an excellent resource to explore the genetic and environmental factors that contribute to long life and successful cognitive aging. The study is ongoing and actively recruiting, with numerous publications in preparation.
Last Update 21/09/2017",SCS,"SCS is a longitudinal cohort exploring the genetic and environmental factors that contribute to long life and successful cognitive aging. Currently 425 participants over 95 have been recruited, 600 is the planned sample size.",Ongoing,"0 to 4,999","Professor Perminder Sachdev","https://cheba.unsw.edu.au/project/sydney-centenarian-study ","Email: a.theobald@unsw.edu.au ","+612 9385 0433","Mr Adam Theobald ﾖ Study Coordinator
Sydney Centenarian Study
Centre for Healthy Brain Ageing (CheBA)
School of Psychiatry, UNSW Medicine","National Health and Medical Research Council, Australia",Ongoing,425,>95,,"Dementia (unclassified)",,"No diagnosis",Australia,,"0 to 4,999","60 to 100","Cognitive function|Mental health|Neurological","Individual psychological","Blood pressure|Height|Hip circumference|Waist circumference|Weight","Hearing and Vision|Musculoskeletal|Respiratory",Blood,"Gene screening","Magnetic resonance imaging (MRI)","Consent for brain donation","Alcohol|Dietary habits|Physical activity|Smoking","Education|Ethnic group|Housing and accommodation|Informal support|Marital status|Occupation and employment|Unpaid care","Formal health and social care service utilisation including private care","Centre for Healthy Brain Ageing; University of New South Wales",
"Rete Geriatrica Alzheimer Project","In this epidemiological study we examined the prevalence of medical comorbidity in elderly subjects with cognitive deficits and dementia. The ReGAl Project (Rete Geriatrica Alzheimer- Geriatric Network on Alzheimer's disease) collected data in 33 Italian Geriatric memory clinics from January 2001 to December 2005. A total of 4,075 patient were recruited.
Last Update 21/09/2017",ReGAI,"The ReGAl Project is an epidemiological study which collected data in 33 Italian Geriatric memory clinics from January 2001 to December 2005. A total of 4,075 patient were recruited.","Jan 2000 - April 2017","0 to 4,999","Professor Patrizia Mecocci and Dr. Virginia Boccardi",,"Email: info@regalproject.it ",,"Prof. Patrizia Mecocci, Section of Gerontology and Geriatrics, Department of Medicine, University of Perugia
Piazza Menghini, 1 IT-06100 Perugia",,"Jan 2000 - April 2017",3897,50-100,,"Alzheimer's disease|Frontotemporal dementia|Lewy body disease|Mild cognitive impairment (MCI)|Parkinson's disease|Subjective memory complaints (SMC) or subjective cognitive decline (SCD)|Vascular dementia",,"No diagnosis",Italy,,"0 to 4,999","40 to 59|60 to 100","Behaviour|Cognitive function|Mental health|Neurological",Caregiver,"Blood pressure|Height|Hip circumference|Waist circumference|Weight","Cardiovascular|Hearing and Vision|Musculoskeletal|Respiratory",,"Gene screening","Magnetic resonance imaging (MRI)|Magnetic resonance spectroscopy (MRS)|Positron emission tomography (PET) fluorine18 flurodeoxyglucose (FDG)",,Alcohol|Smoking,"Education|Ethnic group|Housing and accommodation|Income and finances|Marital status|Occupation and employment|Unpaid care","Formal health and social care service utilisation including private care",,
"Amsterdam dementia cohort","The ADC was setup in 2004 by including all patients who come to the Alzheimer Center for diagnostic work up and who consent to give all data, collected as part of the routine diagnostic work up, for research. The aim is and was to facilitate research into new and existing biomarkers in the broadest sense, to establish diagnostic, prognostic and theragnostic values and further insight into the pathogenesis of neurodegenerative dementias. The data are collected on a weekly basis and consist of baseline data and annual follow up data. Since it is conception it has grown into one of the largest clinical databases in the dementia field. More info on setup, characteristics and data collection can be found in van der Flier WM, Pijnenburg YA, Prins N, Lemstra AW, Bouwman FH, Teunissen CE, van Berckel BN, Stam CJ, Barkhof F, Visser PJ, van Egmond E, Scheltens P.
Optimizing patient care and research: the Amsterdam Dementia Cohort. J Alzheimers Dis. 2014;41(1):313-27. doi: 10.3233/JAD-132306. PubMed PMID: 24614907.
Last Update 21/09/2017",ADC,"ADC is a study aimed at facilitating research into new and existing biomarkers. It began in 2004 and continues to recruit participants under 30.","2004 - present","5,000 to 9,999","Professor Philip Scheltens","http://www.alzheimercentrum.nl","PI Email: p.scheltens@vumc.nl",31204440816,"Alzheimer Center,
Department of Neurology,
VU University Medical Center,
Neuroscience Campus,
Amsterdam,
The Netherlands","Innovatie Fonds Ziektekostenverzekeraars, Stichting Diorapthe and Stichting VUmc fonds","2004 - present",>6000,>30,,"Alzheimer's disease|Dementia (unclassified)|Frontotemporal dementia|Lewy body disease|Mild cognitive impairment (MCI)|Other NDs not listed|Prion disease|Subjective memory complaints (SMC) or subjective cognitive decline (SCD)|Vascular dementia",,"Condition diagnosed",Netherlands,,"0 to 4,999","40 to 59","Behaviour|Cognitive function|Mental health|Neurological","Individual physiological|Individual psychological","Blood pressure|Height|Hip circumference|Waist circumference|Weight","Cardiovascular|Hearing and Vision","Blood|Cerebral spinal fluid (CSF)|CSF biomarker data available|Urine","Gene screening","Electroencephalogram (EEG)|Magnetic resonance imaging (MRI)|Magnetoencephalography (MEG)|Positron emission tomography (PET) - amyloid|Positron emission tomography (PET) fluorine18 flurodeoxyglucose (FDG)","Consent for brain donation",Alcohol,"Education|Marital status","Formal health and social care service utilisation including private care","VU University Medical Center",
"Wisconsin Longitudinal Study","The Wisconsin Longitudinal Study (WLS) is a longitudinal population cohort started in 1957, with a questionnaire administered to all Wisconsin High School seniors. In 1964, a randomly selected one-third of the members of the class of 1957 were followed up with a brief questionnaire to parents asking about their child's post high-school education and occupation. Direct contact with the graduate began with a telephone interview in 1975, and subsequent telephone and mail surveys in 1993 2004. In 1977 a subset of graduate's siblings were interviewed by phone and in 1995 and 2005 interviews were conducted with one sibling from each family whenever possible. Spouses of Graduates and Siblings who were married at the time of the 2004/2005 interview were also interviewed by phone. Most recently in-person interviews with a leave-behind questionnaire were administered in 2011 to both the graduate and sibling panels. Saliva was collected from both graduate and sibling participants via a mail-effort in 2008 and during the in-person 2011 interview.
Last Update 21/09/2017 ",WLS,"WLS is a longitudinal population cohort started in 1957 which gives reserachers the opportunity to study the life course, intergenerational transfers and relationships, family functioning, physical, mental health and well-being of 22,334 participants.",1957,"5,000 to 9,999","Dr. Pamela Herd","http://www.ssc.wisc.edu/wlsresearch/","Dr. Carol L Roan email: roan@ssc.wisc.edu PI email: pherd@lafollette.wisc.edu","(608) 265-6196",,"University of Wisconsin-Madison
1180 Observatory Drive
Madison
53706
Wisconsin, US",1957,9364,>17,,"Alzheimer's disease|Dementia (unclassified)|Parkinson's disease",,"No diagnosis",USA,,"20,000 to 49,999","10 to 19|20 to 39|40 to 59|60 to 100","Behaviour|Cognitive function|Neurological","Individual psychological","Height|Hip circumference|Waist circumference|Weight","Hearing and Vision|Respiratory",Microbiome|Saliva,"Gene screening",,,"Alcohol|Dietary habits|Physical activity|Smoking","Education|Ethnic group|Family circumstances|Housing and accommodation|Income and finances|Informal support|Marital status|Occupation and employment|Unpaid care",,"University of Wisconsin-Madison",
"Next Steps","Next Steps (previously known as the Longitudinal Study of Young People in England - LSYPE) is a major innovative cohort study of young people. The study began in 2004 and included all young people in Year 9, aged between 13 and 14, who attended state and independent schools in England.
Next Steps is one of the main information sources for the formation and appraisal of policies relating to young people and will continue to be so for at least the next 10 years. The baseline data will be used to monitor the progress of the cohort group, evaluate the success of policies aimed at this group and provide an evidence base for further policy development. The study brings together data from a wide range of sources and reflects the variety of influences on learning and progression.
Following the initial survey at age 13-14, the cohort members were visited every year until 2010, when they were age 19-20. Young people were interviewed along with their parents up to sweep 4 (age 17).
The most recent survey took place in 2015/16, when the cohort members were 25 years old. It maintained the strong focus on education, but the content was broadened to become a more multi-disciplinary research resource. Data was collected about cohort members' housing and family life, employment and economic circumstances, education and job training, physical and emotional health, and identity and participation. A wide range of administrative data linkage consents were collected in the domains of health, education, economics and criminal behaviour.
Last Update 21/09/2017","Next Steps","Next steps (formerly LSYPE) began in 2004 by recruiting 16,122 13-14 year olds. The cohort has developed as it has aged from a strong focus on education to a more multi-disciplinary research resource.",16122,"10,000 to 19,999","Dr Lisa Calderwood","http://www.cls.ioe.ac.uk/page.aspx?&sitesectionid=1246&sitesectiontitle=Welcome+to+the+Longitudinal+Study+of+Young+People+in+England ","Email: l.calderwood@ucl.ac.uk ","+44 (0)20 7612 6875","Centre for Longitudinal Studies
UCL Institute of Education
20 Bedford Way
London
WC1H 0AL","Department of Education (sweeps 1-7)
Economic and Social Research Council (sweep 8)",16122,,13-14,,,,"No diagnosis","United Kingdom",,"10,000 to 19,999","10 to 19|20 to 39","Behaviour|Mental health","Individual physiological|Individual psychological",Height|Weight,"Hearing and Vision|Reproductive",,,,,"Alcohol|Dietary habits|Physical activity|Smoking","Education|Ethnic group|Family circumstances|Housing and accommodation|Income and finances|Informal support|Marital status|Occupation and employment|Unpaid care",,"University College, London",
"The Swedish BioFINDER Study","The Swedish BioFINDER Study consists of four cohorts where patients are included prospectively and followed longitudinally (www.biofinder.se). At baseline, these individuals undergo detailed and standardized cognitive, neurological and psychiatric examinations. Plasma, blood, CSF and samples for cell biology studies are collected. Most also have also undergone advanced Magnetic Resonance Imaging, and in many of the non-demented cases Amyloid and Tau positron emission tomography (PET) imaging have also been done.
The subcohorts include:
i) Healthy volunteers. Ca 350 volunteers aged 60-100 years old from the population-based Malm' EPIC cohort (380 participants as of Feb 2016). Follow-up time: at least 8 years with investigations repeated every second year. In this cohort, appr. 20% is expected to have preclinical AD.
ii) Patients with Mild Cognitive Impairment (MCI) or Subjective Cognitive Decline (SCD). Ca 500 patients with MCI/SCD aged 60-80 years. Follow-up time: at least 6 years with investigations repeated every year. In this cohort, appr. 50% is expected to have prodromal AD.
iii) Patients with different dementia disorders. We include ca 250 dementia cases aged 40-100 years with AD, VaD, DLB, PDD or FTD. Follow-up time: at least 2 years with investigations repeated every year.
IV) Patients with Parkinson's disease (PD) and PD-related disorders. Ca 300 patients with Parkinson-like symptoms. Follow-up time: at least 6 years with investigations repeated every year.
Last Update 21/09/2017",BioFINDER,"The Swedish BioFINDER Study consists of four cohorts, at baseline these individuals undergo detailed and standardized cognitive, neurological and psychiatric examinations. 1,400 participants over the age of 60 have been recruited.",2009-2014,,"Professor Oskar Hansson","http://biofinder.se/biofinder_cohorts/ ","Email: oskar.hansson@med.lu.se ","+46 40 33 50 36","SUS,
VO Minnessjukdomar,
Simrisbanv 14/4,
Malm',
Sweden","The European Research Council|The Swedish Research Council|The Crafoord Foundation|The Swedish Brain Foundation|The Strategic Research Area MultiPark (Multidisciplinary Research in Parkinson's disease) at Lund University|The Sk'ne University Hospital Foundation|The Swedish Alzheimer Association|The Swedish federal government under the ALF agreement|The Swedish Parkinson foundation|The foundation Gamla Tj'narinnor|The Evy and Gunnar Sandberg Foundation|The Olle Engkvist Foundation|The Kockska Foundation for Medical Research",2009-2014,,>60,,"Alzheimer's disease|Frontotemporal dementia|Lewy body disease|Mild cognitive impairment (MCI)|Parkinson's disease|Subjective memory complaints (SMC) or subjective cognitive decline (SCD)|Vascular dementia",,"Condition diagnosed",Sweden,,"0 to 4,999","60 to 100","Cognitive function|Mental health|Neurological","Individual physiological|Individual psychological","Blood pressure|Height|Weight","Hearing and Vision|Reproductive","Blood|Cerebral spinal fluid (CSF)|CSF biomarker data available|Other","Gene screening","Magnetic resonance imaging (MRI)|Magnetic resonance spectroscopy (MRS)|Positron emission tomography (PET) - amyloid",,"Alcohol|Dietary habits|Smoking",Education,,"Clinical Memory Research Unit, Lund University",
"STROKOG (The Stroke and Cognition Consortium)","STROKOG is a consortium of longitudinal studies of cognitive disorders following stroke, TIA or small vessel disease. Developed under the auspices of VASCOG (Society for the Study of Vascular Cognitive and Behavioural Disorders), it is the first international effort to harmonise work on post-stroke dementia and is being led by CHeBA researchers.
The consortium brings together studies that have examined post-stroke or other high vascular risk cohorts longitudinally, with cognitive decline and dementia (including sub-types) as primary outcome variables. The included studies (N=27; total sample of more than 10,000 individuals, representing 17 countries) have rich neuropsychological and MRI data, and some recent studies (n=3) have included amyloid imaging in sub-samples. A number of studies have CSF and/or plasma available for biomarker studies, and participant enrolment in brain banks for neuropathology.
Last Update 21/09/2017",STROKOG,"STROKOG is a consortium of longitudinal studies of cognitive disorders following stroke, TIA or small vessel disease.",Ongoing,"10,000 to 19,999","Perminder Sachdev","https://cheba.unsw.edu.au/group/strokog","Email: p.sachdev@unsw.edu.au",,"CHeBA (Centre for Healthy Brain Ageing)
UNSW Medicine","Vincent Fairfax Family Foundation",Ongoing,16000,>12,,"Mild cognitive impairment (MCI)",,"No diagnosis","Australia|Finland|France|Germany|Hong Kong|Ireland|Netherlands|Nigeria|Poland|Singapore|South Africa|South Korea|Sweden|United Kingdom|USA",,"10,000 to 19,999","0 to 9|10 to 19","Behaviour|Cognitive function|Mental health|Neurological","Individual physiological|Individual psychological","Blood pressure|Height|Weight",Cardiovascular,Blood,"Gene screening","Magnetic resonance imaging (MRI)|Positron emission tomography (PET) - amyloid|Positron emission tomography (PET) fluorine18 flurodeoxyglucose (FDG)","Consent for brain donation","Alcohol|Physical activity|Smoking","Education|Ethnic group|Marital status",,Multiple,
"Southampton Women’s Survey","Between 1998 and 2002 the Survey team interviewed over 12,583 Southampton women aged 20 to 34 years. Those who became pregnant after interview were invited to take part in the pregnancy phase of the survey. Women received ultrasound scans at 11, 19 and 34 weeks of pregnancy, and their babies were measured soon after birth. There were 3,158 babies born to women in the study between 1998 and 2007. The survey has followed up these children with home visits at six months, one year, two and three years. A sample of over 1,000 children was seen at 4 years of age, more than 2,000 children at ages 6-7 years, and more than 1,000 at 8-9 years. Current follow-up of children at 11-13 years will continue for a number of years.
The aim is to learn more about the dietary,lifestyle, hormonal and omic factors that influence the health of women and their children.
Last Update 21/09/2017",SWS,"SWS aims to learn about the dietary, lifestyle, hormonal and ﾑomic factors that influence the health of women and their children. 12,583 women were interviewed between 1998 and 2002 and 3158 children were born to those women.",1998-2002,"0 to 4,999","Professor Hazel Inskip","http://www.mrc.soton.ac.uk/sws/","Email: sws@mrc.soton.ac.uk",,,"University of Southampton|UK Medical Research Council|Dunhill Medical Trust|British Heart Foundation|Food Standards Agency|European Union Seventh Framework Programme|NIHR Southampton Biomedical Research Centre",1998-2002,2000,20-34,,,,"No diagnosis","United Kingdom",,"10,000 to 19,999","0 to 9|10 to 19|20 to 39|40 to 59","Behaviour|Cognitive function|Mental health",,"Blood pressure|Height|Waist circumference|Weight",Cardiovascular|Musculoskeletal|Reproductive|Respiratory,Blood|Other|Urine,"Gene screening",,,"Alcohol|Dietary habits|Physical activity|Smoking","Education|Ethnic group|Family circumstances|Housing and accommodation|Income and finances|Marital status|Occupation and employment",,"University of Southampton",
"Quebec Longitudinal Study on Nutrition and Successful Aging","General objectives of the NuAge Study:
1. To assess changes in dietary intakes of ageing men and women (foods, energy, macronutrients, micronutrients) and longterm exposure to functional foods from a qualitative and quantitative perspective;
2. To assess the influence of longstanding and current dietary habits and evolving food choices on changes in numerous markers of physical and cognitive status, functional autonomy and social functioning;
3. To assess the impact of age-related alterations in energy metabolism (utilisation and expenditure) and body composition, on changes in numerous markers of physical and cognitive status, functional autonomy and social functioning;
4. To assess the impact of individual (biological, psychological, health, functional, behavioural) and environmental determinants on dietary intakes.
The population is comprised of 1793 healthy men and women, selected from three age groups (68ﾖ72, 73ﾖ77, 78ﾖ82) at recruitment. A total of 82.4% of the population is French speaking participants and a total of 14.3% is English speaking participants.
Last Update 21/09/2017",NuAge,"NuAge is a population study looking at dietary and nutritional factors on biological, psychological, health, functional and behavioural aspects of ageing. It began in 2004 and had 1793 participants at baseline.",2004-2015,"0 to 4,999","Dr H'l'ne Payette","https://www.maelstrom-research.org/mica/study/nuage ","PI Email: helene.payette@usherbrooke.ca Co-PI Email: pierrette.gaudreau@umontreal.ca, jose.morais@mcgill.ca, bryna.shatenstein@umontreal.ca ","1-819-780-2220 ext.45636","Research Center on Aging, Health and Social Services Centre ﾗ University Institute of Geriatrics of Sherbrooke (CSSS-IUGS)
1036 Belv'd're Street
Sherbrooke
J1H 4C4
Qu'bec, Canada","Canadian Institute for Health Research (CIHR), Quebec Network for Research on Aging, Fonds de Recherche en Sant' du Qu'bec (FRQS) and Pfizer-FRQS Innovation Fund for Alzheimer's Disease and Related Disorders",2004-2015,585,68-82,,,,"No diagnosis",Canada,,"0 to 4,999","60 to 100","Cognitive function|Mental health","Individual physiological|Individual psychological","Blood pressure|Height|Waist circumference|Weight","Cardiovascular|Hearing and Vision|Musculoskeletal|Reproductive|Respiratory",Blood|Saliva|Urine,"Gene screening",,,"Alcohol|Dietary habits|Physical activity|Smoking","Education|Family circumstances|Housing and accommodation|Income and finances|Informal support|Marital status|Occupation and employment","Formal health and social care service utilisation including private care","Research Center on Aging, Health and Social Services Centre ' University Institute of Geriatrics of Sherbrooke (CSSS-IUGS)",
"Cooperative health research in the Region of Augsburg","KORA stands for ""Kooperative Gesundheitsforschung in der Region Augsburg"" (Cooperative Health Research in the Augsburg Region). KORA studies are conducted at regular intervals in order to assess the health status of the population in Augsburg and the surrounding area since 1984. The extensive database and biological specimen repository provide an excellent platform for national and international health research. More than 200 research projects a year are conducted with regional, national and international partners. To date, more than 2,000 publications have been issued. The main research areas are:
- Lifestyle and environmental factors as risk factors in the development of chronic diseases
- Identifying new genes for the most important chronic diseases and related risk factors
- Integrating research into risk factors and functional genomics
- Research on health systems: usage, costs and health status
Last Update 21/09/2017",KORA,"KORA is a regional research platform for population-based surveys which began in 1984. The extensive database and biological specimen repository provide an excellent platform for national and international health research.",1984-2001,"10,000 to 19,999","Prof. Dr. Annette Peters|KORA Board Members: Prof. Dr. Reiner Leidl|Prof. Dr. Konstantin Strauch|Prof. Holger Schulz|Dr. Christian Gieger","http://www.bioshare.eu/content/kora-cooperative-health-research-region-augsburg ","PI Email: peters@helmholtz-muenchen.de PI Email: leidl@helmholtz-muenchen.de PI Email: strauch@helmholtz-muenchen.de PI Email: schulz@helmholtz-muenchen.de PI Email: gieger@helmholtz-muenchen.de PI Email: ladwig@helmholtz-muenchen.de ",,"Helmholtz Centre Munich -
German Research Center
Health and Environment (GmbH)
Institute of Epidemiology II
Ingolst'dter Landstr. 1
D-85764 Neuherberg
Germany","Helmholtz Zentrum M'nchen ' German Research Center for Environmental Health, which is funded by the German Federal Ministry of Education and Research (BMBF) and by the State of Bavaria.",1984-2001,13000,25-74,,,,"No diagnosis",Germany,,"10,000 to 19,999","20 to 39|40 to 59|60 to 100","Cognitive function|Mental health|Neurological",,"Blood pressure|Height|Waist circumference|Weight","Cardiovascular|Hearing and Vision|Musculoskeletal|Respiratory",Blood|Microbiome|Saliva|Urine,"Gene screening","Magnetic resonance imaging (MRI)",,"Alcohol|Dietary habits|Physical activity|Smoking","Education|Income and finances|Informal support|Marital status|Occupation and employment|Unpaid care","Formal health and social care service utilisation including private care","Institute for Epidemiology II",
"The German Study on Ageing, Cognition, and Dementia","The German Study on Ageing, Cognition, and Dementia (AgeCoDe) in primary care patients is an ongoing multicenter prospective study in elderly individuals with a focus on the identification of risk factors and predictors of cognitive decline and dementia.
Between January 1, 2003 and November 30, 2004 a total of 3327 subjects free of dementia at baseline were recruited from general practitioner (GP) registries and assessed with structured clinical interviews and cognitive tests. Since then, participants as well as their proxies were interviewed by trained staff every 1.5 years. In 2016 follow-up 9 was completed.
Main inclusion criteria were ages greater than 75 years, native German language, absence of severe hearing or vision impairments, and residing at home rather than in an institution.
The approval of this study was provided by the local ethics committees of the Universities of Bonn, Hamburg, D'sseldorf, Heidelberg/Mannheim, Leipzig, and Munich. All subjects gave written informed consent before the participation in this study.
Of the 3,327 patients interviewed at baseline, 84.8% (n = 2,820) could be personally interviewed 1.5 years later and 73.9% (n = 2,460) 3 years later. For the vast majority of subjects who could not be personally interviewed, systematic assessments, focusing particularly on dementia, were obtained from GPs, relatives or caregivers.
Last Update 21/09/2017",AgeCoDe,"AgeCoDe is a prospective study with a focus on the identification of risk factors and predictors of cognitive decline and dementia. Between 2003-2004 3327 participants were recruited aged over 75.",,"0 to 4,999","Dr Siegfried Weyerer","http://www.alzrisk.org/cohort.aspx?cohortID=45&rfid=12 ","Email: siegfried.weyerer@zi-mannheim.de ",,,"German Federal Ministry of Education and Research",,,>75,,"Alzheimer's disease|Dementia (unclassified)|Mild cognitive impairment (MCI)|Subjective memory complaints (SMC) or subjective cognitive decline (SCD)",,"No diagnosis",Germany,,"0 to 4,999","60 to 100","Cognitive function|Mental health|Neurological","Individual psychological",,,Blood,"Gene screening",,,"Alcohol|Dietary habits|Physical activity|Smoking","Education|Housing and accommodation",,"Central Institute of Mental Health, Mannheim, Germany",
"The Australian Longitudinal Study of Ageing","The Australian Longitudinal Study of Ageing (ALSA) is the centrepiece research activity of the Flinders Centre for Ageing Studies. The ALSA commenced in 1992 with 2087 participants aged 65 years or more. At Baseline, a comprehensive personal interview and assessment of neuropsychological and physiological functions was undertaken at each person's home, supplemented by self-completed questionnaires, biochemistry, and additional clinical studies of physical function. The final wave (Wave 13) of data collection was carried out in 2014.
The general purpose of the ALSA study is to gain further understanding of how social, biomedical and environmental factors are associated with age related changes in health and well-being of persons aged 70 years and over. Emphasis is given in the overall study to defining and exploring the concept of healthy, active ageing, particularly in a South Australian context.
Last Update 21/09/2017",ALSA,"ALSA is a population study focused on how social, biomedical and environmental factors are associated with age related changes in health and well-being of persons aged 70 and over. In 1992 2,087 participants were recruited.",1992,,"Professor Mary Luszcz","http://flinders.edu.au/sabs/fcas/alsa/alsa.cfm ","Email: fcas@flinders.edu.au ","(08) 8201 7588 OS: +618 8201 7588 (or2192)","Flinders Centre for Ageing Studies
School of Psychology
GPO Box 2100
Adelaide SA 5001
Australia","US National Institute on Ageing|Australian Research Council (Discovery Program)|The National Health and Medical Research Council, Australia",1992,,>65,,,,"No diagnosis",Australia,,"0 to 4,999","60 to 100","Behaviour|Cognitive function|Mental health|Neurological","Individual physiological|Individual psychological","Blood pressure|Height|Waist circumference|Weight","Cardiovascular|Hearing and Vision|Musculoskeletal|Reproductive|Respiratory",Blood,,,,"Alcohol|Dietary habits|Physical activity|Smoking","Education|Ethnic group|Family circumstances|Housing and accommodation|Income and finances|Informal support|Marital status|Occupation and employment|Unpaid care","Formal health and social care service utilisation including private care","Flinders Centre for Ageing Studies",
"Australian Imaging, Biomarker & Lifestyle Flagship Study on Ageing","AIBL is a study of over 2,000 people assessed over a long period of time (over 10 years) to determine which biomarkers, cognitive characteristics, and health and lifestyle factors determine subsequent development of symptomatic Alzheimer's Disease (AD).
The baseline inception cohort consisted of:
i. 211 individuals with AD as defined by NINCDS-ADRDA (McKhann et al, 1984);
ii. 133 individuals with Mild Cognitive Impairment (MCI)
iii. 768 healthy individuals without cognitive impairment. This group included volunteers with at least one copy of the ApoE ?4 allele, volunteers without a copy of the ApoE ?4 allele and 396 volunteers who expressed subjective concern about their memory function.
The enrichment cohort consists of:
i. 142 individuals with AD
ii. 220 individuals with MCI
iii. 582 individuals with without cognitive impairment.
The data was collected through clinics and questionnaires.
Last Update 21/09/2017",AIBL,"AIBL is an ND specific cohort aimed at identifying biomarkers, cognitive characteristics, and health and lifestyle factors associated with the development of AD. It began in 2006 recruiting 2,500 participants over 60.","2006-2008| 2010","0 to 4,999","Professor David Ames","https://aibl.csiro.au/about/","Email: dames@unimelb.edu.au",,"Data Accesshttps://aibl.csiro.au/research/support/ ","Science and Industry Endowment Fund","2006-2008| 2010",2100,>60,,"Alzheimer's disease|Mild cognitive impairment (MCI)|Other NDs not listed|Subjective memory complaints (SMC) or subjective cognitive decline (SCD)",,"Condition diagnosed",Australia,,"0 to 4,999","60 to 100","Behaviour|Cognitive function|Mental health|Neurological",,"Blood pressure|Height|Waist circumference|Weight",,"Blood|Cerebral spinal fluid (CSF)|CSF biomarker data available|Microbiome|Other|Saliva|Urine","Gene screening","Magnetic resonance imaging (MRI)|Positron emission tomography (PET) - amyloid",,Alcohol|Smoking,"Education|Marital status","Formal health and social care service utilisation including private care","Florey Institute of Neuroscience and Mental Health, Austin Health, Edith Cowan University and CSIRO",
"The Irish Longitudinal Study on Ageing","The Irish Longitudinal Study on Ageing (TILDA) is a large-scale, nationally representative, longitudinal study on ageing in Ireland, the overarching aim of which is to make Ireland the best place in the world to grow old.
TILDA collects information on all aspects of health, economic and social circumstances from people aged 50 and over in a series of data collection waves once every two years. TILDA is unique amongst longitudinal studies in the breadth of physical, mental health and cognitive measures collected. This data, together with the extensive social and economic data, makes TILDA one of the most comprehensive research studies of its kind both in Europe and internationally.
Last Update 21/09/2017",TILDA,"TILDA is a large-scale, nationally representative, longitudinal study on ageing in Ireland. It began in 2009 and recruited 8,175 over 50 year olds.",2009,,"Professor Rose Anne Kenny","http://tilda.tcd.ie/ ","Email: tilda@tcd.ie ","Phone contact: +353 1 896 2509","The Irish Longitudinal Study of Ageing (TILDA)
Lincoln Gate
Trinity College
Dublin 2
Republic of Ireland","Trinity College Dublin",2009,,>50,,"Alzheimer's disease|Dementia (unclassified)|Parkinson's disease|Subjective memory complaints (SMC) or subjective cognitive decline (SCD)",,"No diagnosis",Ireland,,"5,000 to 9,999","40 to 59|60 to 100","Cognitive function|Mental health|Neurological","Individual physiological|Individual psychological","Blood pressure|Height|Hip circumference|Waist circumference|Weight","Cardiovascular|Hearing and Vision|Musculoskeletal|Respiratory",Blood|Other,,"Magnetic resonance imaging (MRI)",,"Alcohol|Dietary habits|Physical activity|Smoking","Education|Ethnic group|Family circumstances|Housing and accommodation|Income and finances|Informal support|Marital status|Occupation and employment|Unpaid care","Formal health and social care service utilisation including private care","Trinity College Dublin",
"The PROTECT Study","The PROTECT Study will gather data and support innovative research to improve our understanding of the ageing brain and why people develop dementia.
We know that certain factors such as exercise, smoking and blood pressure affect our risk of dementia, and there is increasing evidence that our genes also play a role.
Participants in PROTECT will provide information about themselves and complete online assessments to measure their abilities such as memory and reasoning. By repeating these assessments each year we will monitor how they change over the study. Participants will also provide a sample of their DNA through a simple at-home kit. PROTECT participants will also have the opportunity to take part in innovative studies to answer crucial questions such as:

How do key measures, such as memory, language and reasoning change over time as we age

How do our lifestyle choices, including our exercise habits and diet affect our risk of dementia

What role do genetics play in the ageing brain? How do they affect how our brain functions and what is their influence on development of dementia?

What are the early signs of dementia and how can they be distinguished from normal ageing

What approaches can be delivered online to influence the ageing process and the development of dementia?

Last Update 21/09/2017",,"The PROTECT study is a population based study looking at the ageing brain and why people develop dementia. Recruitment is ongoing and is estimated it will reach over 5,000 over 50 year olds.","2014- ongoing","0 to 4,999","Professor Clive Ballard","http://www.protectstudy.org.uk/about.aspx ","Email: admin@protectstudy.org.uk ","Tel: 0207 848 8183","PROTECT study, Clinical Trials Team
Wolfson Centre for Age-Related Diseases
Guy's Campus
King's College London
London SE1 1UL","NIHR Biomedical Research Unit for dementia","2014- ongoing",23000,>50,,"Mild cognitive impairment (MCI)|Parkinson's disease",,"No diagnosis","United Kingdom",,"5,000 to 9,999","40 to 59|60 to 100","Behaviour|Cognitive function|Mental health|Neurological","Individual psychological",Height|Weight,,Saliva,,,,"Alcohol|Dietary habits|Physical activity|Smoking","Education|Ethnic group|Marital status","Formal health and social care service utilisation including private care","King's College London",
"The Metropolit 1953 Danish Male Birth Cohort","The original aim of the Metropolit cohort was to follow men from early school age to early mid-life, to explore intergenerational mobility and differential life-chances. In 2001 the cohort was revitalised in order to study the development of chronic diseases in a life course perspective.
The Metropolit cohort comprises all 11532 men born in 1953 in the Copenhagen Metropolitan area who were living in Denmark in 1968. These men have been followed repeatedly since their birth. In brief, we have data from birth certificates (1953) which include information on birth dimensions and father's occupation. In 1965, 7,987 participated in a school-based survey and completed tests of cognition and enquiries regarding leisure-time activities and social aspirations. Data from draft board examinations at around age 19 have been collected for 11,108 of the men. These data include cognitive testing and health information. In 2004, 6,292 of the men responded to a mailed questionnaire with questions on health and lifestyle. In 2009-2010, 2486 of 7799 eligible cohort members participated in the Copenhagen Ageing Midlife Biobank (CAMB) study which comprised questionnaires, cognitive and physical testing as well as blood sampling. Further, around 300 men selected on their young adult and current cognitive performance have been through a neurophysiological examination including EEG, MRI, fMRI and sleep tests. The cohort has also been followed in nation-wide social and health registers for social life, medical and mental hospital diagnosis as well as cause of death from 1969 to 2016.
Last Update 21/09/2017","Metropolit cohort","The Metropolit cohort comprises all 11,532 men born in 1953 in the Copenhagen Metropolitan area who were living in Denmark in 1968. The aim is to explore intergenerational mobility and differential life-chances.",2001,,"Professor Merete Osler","www.metropolit.dk; www.camb.ku.dk; https://academic.oup.com/ije/article/35/3/541/735517/Cohort-Profile-The-Metropolit-1953-Danish-Male ","PI email: merete.osler@regionh.dk ",,"Research Center for Prevention and Health
Center for Health
Metropolitan Region
Rigshospitalet -Glostrup (University of Copenhagen)
Ndr. Ringvej 57, section 84/85
2600 Glostrup","Danish Heart Association, the Lundbeck foundation, the Danish Health Insurance Foundation, the Danish Pharmaceutical Fund, and Else and Mogens Wedell-Wedellsborgs Fund, Velux Foundation",2001,,"> 0",,"Alzheimer's disease|Dementia (unclassified)|Parkinson's disease|Vascular dementia",,"No diagnosis",Denmark,,"10,000 to 19,999","0 to 9|10 to 19|20 to 39|40 to 59","Cognitive function|Mental health|Neurological","Individual physiological|Individual psychological","Blood pressure|Height|Hip circumference|Waist circumference|Weight",Reproductive|Respiratory,Blood,"Gene screening","Electroencephalogram (EEG)|Magnetic resonance imaging (MRI)",,"Alcohol|Dietary habits|Physical activity|Smoking","Education|Family circumstances|Housing and accommodation|Income and finances|Informal support|Marital status|Occupation and employment|Unpaid care","Formal health and social care service utilisation including private care","Research Center for Prevention and Health, Rigshospitalet- Glostrup University of Copenhagen",
"The Alzheimer’s and Families study","The aim of the Alfa Study is to focus on the processes taking place before the initiation of Alzheimer's symptoms in order to design interventions to prevent or delay the onset of dementia. Inclusion criteria were being cognitively normal Spanish and/or Catalan-speaking persons aged between 45 and 74 years that agreed with the study procedures and tests: clinical interview and questionnaires associated to risk factors, cognitive tests, a blood sample extraction for DNA analysis, and MRI.
A subset (n=450) of the ALFA parent cohort participants are currently being recruited / undergoing a nested longitudinal long-term study, named the ALFA+ study, in which a more detailed phenotyping will be performed. On top of a similar characterization as in the ALFA parent cohort, it will entail the acquisition of both wet (CSF, blood, and urine sample collection) and imaging (magnetic resonance imaging [MRI] and PET) biomarkers. Furthermore, ALFA parent cohort participants may also be invited to participate in other BBRC studies such the ALFAlife primary intervention study (n=400) or the full genetic and neuroimaging characterisation study referred to as ALFAgenetics (n=2000).
Last Update 21/09/2017","Alfa Study","The Alfa Study recruited 2,743 participants between 2013 and 2014. It is focused on the processes before the initiation of Alzheimer's symptoms in order to design interventions to prevent or delay the onset of dementia.","Apr 2013-Nov 2014","0 to 4,999","Dr. Jos' Luis Molinuevo","https://fpmaragall.org/en/research-alzheimer/alfa-study-against-alzheimer/ ","PI Email: jlmolinuevo@fpmaragall.org ","Tel. +34 933160990","Barcelona eta Brain Research Center
Wellington, 30
08005 Barcelona
Tel. +34 933160990","Pasqual Maragall Foundation (FPM)","Apr 2013-Nov 2014",2700,45-75,,"Alzheimer's disease|Mild cognitive impairment (MCI)|Subjective memory complaints (SMC) or subjective cognitive decline (SCD)",,"At-risk diagnosis",Spain,,"0 to 4,999","40 to 59|60 to 100","Behaviour|Cognitive function|Mental health|Neurological","Caregiver|Individual physiological|Individual psychological","Blood pressure|Height|Hip circumference|Waist circumference|Weight","Cardiovascular|Hearing and Vision|Musculoskeletal|Reproductive|Respiratory","Blood|Cerebral spinal fluid (CSF)|CSF biomarker data available","Gene screening","Magnetic resonance imaging (MRI)|Positron emission tomography (PET) - amyloid|Positron emission tomography (PET) fluorine18 flurodeoxyglucose (FDG)",,"Alcohol|Dietary habits|Physical activity|Smoking","Education|Ethnic group|Family circumstances|Housing and accommodation|Income and finances|Marital status|Occupation and employment","Formal health and social care service utilisation including private care","Barcelona?eta Brain Research Center",
"Aberdeen Children of the 1950s","The Children of the 1950s study is a population-based resource for the study of biological and social influences on health across the life-course and between generations.
Comprising individuals born in Aberdeen, Scotland between 1950 and 1956, this cohort is based on the 12,150 people who took part in the Aberdeen Child Development Survey, a cross-sectional study in a population of all children who were attending an Aberdeen primary school in December 1962. The data collected include information on birth weight, childhood height and weight, tests of cognition and behavioural disorder, and a range of multi-level socio-economic indicators.
In the early 2000s the current vital status and whereabouts of 98.5% of the 12,150 subjects (6276 males, 5874 females) with full baseline data were ascertained. The large majority (81%) of study participants still resided in Scotland and the majority (73%) remained in the Grampian region which incorporates Aberdeen.
Linkages to hospital admissions and other health endpoints captured through the routine Scottish Morbidity Records system have been completed. A postal questionnaire to all surviving cohort members was distributed in 2001, with a response proportion of 63%.
The cohort database is now maintained as a resource for researchers, with over 40 publications to data resulting from interrogation of the data.
Last Update 21/09/2017",ACONF,"ACONF is a population-based resource for the study of biological and social influences on health across the life-course and between generations. 12150 participants were recruited aged 7-12years between 1950 and 1956.",1962,,"Professor Phil Hannaford","https://www.abdn.ac.uk/birth-cohorts/1950s/for-researchers/","Email: children1950s@abdn.ac.uk","Telephone: +44 (0)1224 438443",,N/A,1950-1956,,7-12,,,,"No diagnosis","United Kingdom",,"10,000 to 19,999","0 to 9|10 to 19","Behaviour|Cognitive function|Neurological",,Height|Weight,Cardiovascular|Reproductive|Respiratory,,,,,"Alcohol|Physical activity|Smoking","Education|Family circumstances|Housing and accommodation|Income and finances|Marital status|Occupation and employment","Formal health and social care service utilisation including private care","University of Aberdeen",
"The Rhineland Study","The Rhineland Study is a prospective cohort study, which began in March 2016. It will include up to 30,000 participants from Bonn and asses their physical and mental health over their lifespan. The study is scheduled to run for decades and participants will be re-examined every 3-4 years.
As neurodegenerative diseases and their pathologies develop over a long time before first symptoms start to show, the Rhineland Study will include men and women aged 30 years and above regardless of their health status.
The main aims of the study are:
1. To investigate modifiable and non-modifiable causes of neurodegenerative and neuropsychiatric diseases
2. To find biomarkers/(multimodal) biomarker profiles to identify individuals at risk for neurodegenerative or neuropsychiatric disease, who might benefit from preventive interventions
3. To investigate (patho)physiology over the adult life course, with specific emphasis on brain-related outcomes.
Last Update 21/09/2017",,"The Rhineland Study is a prospective cohort study aimed at finding the causes of neurodegenerative and neuropsychiatric diseases. It began in March 2016 and plans to recruit up to 30,000 over 30 year olds.","2016 - Present","10,000 to 19,999","Prof. Dr. Monique M. B. Breteler","www.rheinland-studie.de; https://www.dzne.de/en/science-society/rheinland-studie.html ","PI Email: monique.breteler@dzne.de ","Tel: +49 (0) 228 / 43302-929","German Center for Neurodegenerative Diseases (DZNE)
Sigmund-Freud-Str. 27
53127 Bonn","Long term institutional core funding","2016 - Present",1000,>30,,"Dementia (unclassified)|Parkinson's disease|Subjective memory complaints (SMC) or subjective cognitive decline (SCD)",,"No diagnosis",Germany,,"10,000 to 19,999","20 to 39|40 to 59|60 to 100","Behaviour|Cognitive function|Mental health|Neurological","Individual physiological|Individual psychological","Blood pressure|Height|Hip circumference|Waist circumference|Weight","Cardiovascular|Hearing and Vision|Reproductive",Blood|Microbiome|Other|Urine,"Gene screening","Magnetic resonance imaging (MRI)",,"Alcohol|Dietary habits|Physical activity|Smoking","Education|Ethnic group|Family circumstances|Housing and accommodation|Income and finances|Informal support|Marital status|Occupation and employment|Unpaid care",,"The German Center for Neurodegenerative Diseases (DZNE)",
"The Doetinchem Cohort Study","For 30 years (since 1987) tracks the health of a group of randomly selected adult Dutch inhabitants of Doetinchem from originally between 20-60 years. This provides a wealth of information of four generations: 20-29, 30-39, 40-49 and 50-60 year olds. The name of this study is the Doetinchem Cohort Study. Every five years the health and habits of the participants are examined at the local health department.
The purpose of the Doetinchem Cohort Study is to give insight into trends in lifestyle and health. So there will be more and more knowledge about why some people age without many problems, while others have health problems at an early age. The study collects data on:

",,"The purpose of the Doetinchem Cohort Study is to give insight into trends in lifestyle and health. For 30 years beginning in 1987, 7,800 participants aged between 20 and 60 have been studied.",1987-1991,"0 to 4,999","Dr W.M.M. Verschuren","http://www.rivm.nl/Onderwerpen/D/Doetinchem_Cohort_Studie","Email: info@rivm.nl PI Email: Monique.verschuren@rivm.nl Project Leader Dr H.S.J Pcavet; susan.picavet@rivm.nl","Tel: +31 (0)301749111",,"National Institute for Public Health and the Environment",1987-1991,4000,20-60,,,,"No diagnosis",Netherlands,,,"20 to 39|40 to 59|60 to 100","Cognitive function|Mental health|Neurological","Individual physiological|Individual psychological","Blood pressure|Height|Hip circumference|Waist circumference|Weight","Cardiovascular|Hearing and Vision|Musculoskeletal|Reproductive|Respiratory",Blood|Urine,"Gene screening",,,"Alcohol|Dietary habits|Physical activity|Smoking","Education|Family circumstances|Informal support|Marital status|Occupation and employment|Unpaid care","Formal health and social care service utilisation including private care","National Institute for Public Health and the Environment",
"Characterization of Predictors of Progressive Progressions of Alzheimer’s Disease","The rpAD study is a longitudinal study, which recruits patients from the entire federal territory. In addition, patients from the Clinical Dementia Centre are recruited at the Neurological and Psychiatric Clinic of the University Medical Center of G'ttingen, with these usually classical clinical forms being internal controls. The aim of the study is to characterize the biological factors and parameters that define the disease progression in AD.
After the patient is informed and consent is given, the inclusion examination is carried out. It includes a detailed history and anamnesis as well as a physical examination, which includes an in-depth examination of the neurological status. A neuropsychological test for cognitive testing is performed using the CERAD-plus test battery. Furthermore, the GDS score is obtained, which allows an assessment of the severity of the cognitive deficits by means of a 7-stage classification. The ADL score is used to assess the activities of daily life (Lawton and Brody 1969).
Six months after the initial examination, a telephone follow-up is carried out. Further investigations are carried out on an annual basis and correspond to the initial examination.
Last Update 21/09/2017","rpAD Study","The rpAD study is a longitudinal study which aims to characterise the biological factors and parameters that define the disease progression in AD. The study began in 2008 and is still recruiting.","2008 - Present","0 to 4,999","Professor Inga Zerr","http://www.knd-demenzen.de/die-verbuende/verbund-rpad/projektbeschreibung.html ","E-mail: ingazerr@med.uni-goettingen.de ","Phone: +49 (0) 551/39 66 36","University Medical School
Department of Neurology
Robert Kochstrasse
40 37075
G'ttingen","Kompetenznetz Degenerative Demenzen -KNDD by BMBF","2008 - Present",300,70,,"Alzheimer's disease",,"Condition diagnosed",Germany,,,"60 to 100","Cognitive function|Mental health|Neurological","Individual physiological|Individual psychological","Blood pressure|Height|Weight",Cardiovascular,"Blood|Cerebral spinal fluid (CSF)|CSF biomarker data available","Gene screening","Electroencephalogram (EEG)|Magnetic resonance imaging (MRI)|Positron emission tomography (PET) fluorine18 flurodeoxyglucose (FDG)","Consent for brain donation","Alcohol|Dietary habits|Physical activity|Smoking","Education|Ethnic group|Family circumstances|Housing and accommodation|Informal support|Marital status|Occupation and employment|Unpaid care",,"University Medical School, Department of Neurology, G'ttingen",
"The Older Australian Twin Study","The Older Australian Twins Study is a longitudinal, multi-centre study that investigates healthy brain ageing in older twins (65+ years). OATS commenced in New South Wales in January 2007, in Queensland in December 2007, and in Victoria in February 2008. Since the OATS study started we have followed our twin volunteers up every two years to check on their psychological and physical health. Participants undergo rigorous medical and cognitive function tests, with many participants' also providing bloods samples and having a magnetic resonance imaging (MRI) scan of their brain. In 2015 we finished our 4-year follow ups. OATS assessed 623 participants at baseline, 450 at the 2-year follow up, and 389 completed their 4-year follow-up.
Last Update 21/09/2017",OATS,"OATS is a longitudinal, multi-centre study that investigates healthy brain ageing in older twins (65+ years). It began in 2007 and recruited 623 participants",2007,"0 to 4,999","Professor Perminder Sachdev","https://cheba.unsw.edu.au/project/older-australian-twins-study ","Email: v.catts@unsw.edu.au ",,"Vibeke S. Catts, PhD
Study Coordinator ﾖ Older Australian Twins Study
CHeBA (Centre for Healthy Brain Ageing)
UNSW Medicine, School of Psychiatry","National Health & Medical Research Council (NHMRC) Grants ID401162 (2007-11), ID10424224 (2012), ID1030039 (2012), ID1045325 (2013-15), ID1085606 (2015-17)",2007,389,>65,,"Alzheimer's disease|Dementia (unclassified)|Frontotemporal dementia|Lewy body disease|Mild cognitive impairment (MCI)|Parkinson's disease|Subjective memory complaints (SMC) or subjective cognitive decline (SCD)|Vascular dementia",,"No diagnosis",Australia,,"0 to 4,999","60 to 100","Behaviour|Cognitive function|Mental health|Neurological","Caregiver|Individual physiological|Individual psychological","Blood pressure|Height|Hip circumference|Waist circumference|Weight","Cardiovascular|Hearing and Vision|Reproductive|Respiratory",Blood,"Gene screening","Magnetic resonance imaging (MRI)","Consent for brain donation","Alcohol|Dietary habits|Physical activity|Smoking","Education|Ethnic group|Family circumstances|Informal support|Marital status|Occupation and employment|Unpaid care","Formal health and social care service utilisation including private care","Centre for Healthy Brain Ageing",
"Puerto Rican Elderly: Health Conditions Project","The Puerto Rican Elderly: Health Conditions (PREHCO) study investigates issues affecting the elderly (individuals over 60 years of age) population in Puerto Rico: health status, housing arrangements, functional status, transfers, labor history, migration, income, childhood characteristics, health insurance, use of health services, marital history, mistreat, sexuality, etc. It is an island-wide, longitudinal sample survey of target individuals and their spouses with two waves of data collection: 2002-2003 and 2006-2007.
In the first phase of the PREHCO project, 4,291 elderly persons 60 years or older and 1,442 spouses were interviewed (1,042 of the latter being 60 years or older). A second wave of the project (2006-2007) converted PREHCO in a longitudinal study. In the second wave, those same participants were asked to do a follow-up survey, in which 3,891 target interviews and 1,260 spouse interviews were completed. The deceased and institutionalized participants were also interviewed using a proxy.
Last Update 21/09/2017","PREHCO Project","The PREHCO study investigates issues affecting the elderly (over 60 years of age) population in Puerto Rico. It began in 2002 and 4,291 were recruited in Phase 1.",2002-2003,,"Professor Aberto Palloni, Professor Ana Luisa D'vila and Professor Melba Sanchez-Ayendez","http://www.icpsr.umich.edu/icpsrweb/DSDR/studies/34596 ","PI email: palloni@ssc.wisc.edu ","Tel no: (608) 262-2182","Samuel Preston Professor of Sociology, Emeritus
4434 Sewell Social Sciences","United States Department of Health and Human Services, National Institutes of Health and National Institute on Aging",2002-2003,,>60,,,,"No diagnosis",USA,,"0 to 4,999","60 to 100","Cognitive function|Mental health|Neurological","Caregiver|Individual physiological|Individual psychological","Height|Hip circumference|Waist circumference|Weight","Cardiovascular|Hearing and Vision|Musculoskeletal|Reproductive|Respiratory",,,,,"Alcohol|Dietary habits|Physical activity|Smoking","Education|Ethnic group|Family circumstances|Housing and accommodation|Income and finances|Marital status|Occupation and employment|Unpaid care",,"University of Puerto Rico",
"Born in Bradford","BiB - Children
Recruitment Period: 2007-11
Sample size at start or planned sample size if still recruiting: 13,857
Estimated current sample size: 13,500
Age at recruitment: 0
BiB - Mothers
Start date: 2006-10
Sample size at start or planned sample size if still recruiting: 12,453
Estimated current sample size: 12,000
Age at recruitment: 15-49
BiB - Fathers
Start date: 2006-10
Sample size at start or planned sample size if still recruiting: 3,414
Estimated current sample size: 3,000
Age at recruitment: 16-60
Born in Bradford is a long term study of a population cohort of 13,500 children, born at Bradford Royal Infirmary between March 2007 and December 2010, whose health is being tracked from pregnancy through childhood and into adult life. The information collected from the BiB families is being used to find the causes of common childhood illnesses and to explore the mental and social development of this new generation.
The Born in Bradford cohort study offers a unique window of opportunity to initiate an innovative and multidisciplinary programme of research. By recruiting pregnant women, their partners and their newborn babies to the cohort, this study offers the potential to:

assess the determinants of childhood and adult disease

assess the impact of migration

explore the influences of pregnancy and childbirth on subsequent health

generate and test hypotheses that have the potential to improve health for some of the most disadvantaged within our society.

The Bradford community provides a unique setting for a birth cohort study exploring the determinants of childhood and adult disease because of its diversity of population and high levels of ill-health.
Last Update 21/09/2017",BiB,"BiB is a population cohort design to track the health of children born in Bradford Royal Infirmary and their mothers. 13,857 children and 12,453 mothers were recruited between March 2007 and December 2010.",2006-2011,"20,000 to 49,999","Professor John Wright","http://www.borninbradford.nhs.uk ","Email: borninbradford@bthft.nhs.uk PI Email: john.wright@bthft.nhs.uk ","Tel: 01274 364474","Born in Bradford Office
Bradford Institute For Health Research
Bradford Royal Infirmary
Duckworth Lane
Bradford
BD9 6RJ",,2006-2011,28500,0-60,,,,"No diagnosis","United Kingdom",,"20,000 to 49,999","0 to 9|10 to 19|20 to 39|40 to 59|60 to 100","Cognitive function|Mental health",,"Blood pressure|Height|Hip circumference|Waist circumference|Weight","Cardiovascular|Hearing and Vision|Musculoskeletal|Reproductive|Respiratory",Blood|Other|Saliva|Urine,,,,"Alcohol|Dietary habits|Physical activity|Smoking","Education|Ethnic group|Family circumstances|Housing and accommodation|Income and finances|Marital status|Occupation and employment",,"Bradford Royal infirmary",
"Lausanne cohort 65+","The Lc65+ project is a longitudinal population-based study focusing on the development of frailty after the age of 65. The main methods in the Lc65+ study are:
ﾕ long term observation of subjects, beginning at 65 to 70 years, an age when frailty is still unusual, in order to study its initiation and development;
ﾕ prospective data collection on a large range of health dimensions, including psycho-social characteristics, in order to investigate the temporal sequence linking frailty, its risk factors, modulators, and outcomes:
ﾕ a population approach considering frailty as a central parameter of health in ageing populations that is useful not only for surveillance, but also for the evaluation of preventive interventions.
Follow-up is based on a yearly questionnaire sent by mail to the participant's home. In addition, subjects are invited to the study center every three years for an interview and examination similar to those performed at baseline. The follow-up is unlimited in time and is not interrupted in the case of nursing home admission.
Last Update 21/09/2017",Lc65+,"The Lc65+ project is a longitudinal population-based study focusing on the development of frailty after the age of 65. Recruitment began in 2004, 4731 participants were recruited.","2004,2009 and 2014","0 to 4,999","Prof. Brigitte Santos-Eggimann","http://www.lc65plus.ch/en/lc65_home ","Email: secretariat.uss@chuv.ch PI Email: Brigitte.Santos-Eggimann@chuv.ch ","Tel: +41 21 314 97 70","Lausanne cohorte Lc65+
CHUV - Institute of Social and Preventive Medicine
Health Services Unit
Biopole 2, Route de la Corniche 10, SA-V
CH-1010 Lausanne","City of Lausanne
Public Health Department of the Vaud canton, Lausanne
Lausanne University Hospital (CHUV)
Institute of Social and Preventive Medicine (IUMSP), CHUV, Lausanne
Community Medicine and Health Department (DUMSC), CHUV, Lausanne
Geriatrics and Geriatric Rehabilitation Service, CHUV, Lausanne
Ambulatory Medical Policlinic (PMU), Lausanne
Loterie Romande
Faculty of Biology and Medicine, University of Lausanne
Swiss National Foundation for Scientific Research (SNF)","2004,2009 and 2014",3500,65-70,,"Alzheimer's disease|Parkinson's disease|Subjective memory complaints (SMC) or subjective cognitive decline (SCD)",,"No diagnosis",Switzerland,,"0 to 4,999","60 to 100","Cognitive function","Individual psychological","Blood pressure|Height|Hip circumference|Waist circumference|Weight","Hearing and Vision",,,,,"Alcohol|Dietary habits|Physical activity|Smoking","Family circumstances|Housing and accommodation|Income and finances|Informal support|Occupation and employment","Formal health and social care service utilisation including private care","Lausanne University Institute of Social and Preventive Medicine (IUMSP)",
"Million Women Study","The Million Women Study is the largest study of women's health in the world. In 1996-2001, a quarter of UK women then aged 50-64 years (1.3 million women) joined the study. The aim of the study is to provide reliable information on potentially modifiable causes of common and serious illnesses, to help improve individual and public health. Study participants have provided details about their lifestyle and health and given signed consent for follow-up. Since recruitment their health has been followed mainly through electronic linkage to routinely collected NHS records (only 1.5% loss to follow-up after 20 years) and the whole surviving cohort has been re-contacted 4 times by postal re-survey to update exposures (1999-03, 2006-7, 2009-12 & 2013-14). Subsets of women have completed additional postal and online re-surveys.
Million Women Study is part of the Dementias Platform UK (DPUK), a multi-million pound public-private partnership to accelerate progress in dementias research http://www.mrc.ac.uk/research/facilities/dementias-platform-ukLast update - 13/06/2017",,"The Million Women study is focused on research in dementia, osteoporosis, stroke and other severe disabling conditions. 1.3 Million Women between the ages of 50-64 joined the study in 1996-2001. Details were recorded about their health and lifestyle.",1996-2001,"500,000+","Professor Dame Valerie Beral","http://www.millionwomenstudy.org","millionwomenstudy@ceu.ox.ac.uk","+44 (0)1865 289600","The Million Women Study Co-ordinating Centre
Cancer Epidemiology Unit
Richard Doll Building
Roosevelt Drive
Oxford OX3 7LF","Cancer Research UK
Medical Research Council",1996-2001,1170000,50-64,,,,"No diagnosis","United Kingdom",,"500,000+","40 to 59|60 to 100",,,"Blood pressure|Height|Hip circumference|Waist circumference|Weight","Cardiovascular|Hearing and Vision|Musculoskeletal|Reproductive|Respiratory",Blood,"Gene screening",,"Consent for brain donation","Alcohol|Dietary habits|Physical activity|Smoking","Education|Ethnic group|Family circumstances|Housing and accommodation|Informal support|Marital status|Occupation and employment|Unpaid care","Formal health and social care service utilisation including private care","Cancer Epidemiology Unit, Oxford",
"The EUROSCA Natural History Study","The key goal of EUROSCA-NHS is to determine and compare the rate of disease progression in SCA1, SCA2, SCA3 and SCA6. To this end, a newly developed and validated ataxia scale (Scale for the Assessment and Rating of Ataxia, SARA) will be used. EUROSCA-NHS has a number of secondary aims including determination of the order and occurrence of non-ataxia symptoms, assessment of activities of daily living (ADL) and quality of life (QoL), and identification of predictors of disease progression and survival.
Patients are first seen at a baseline visit, followed by annual visits for 3 years scheduled ﾱ 3 months around the specified time point. After the initial 3 year observation period, visits are done at irregular intervals each time they went to hospital.
Last update - 12/08/2017",EUROSCA,"The key goal of EUROSCA-NHS is to determine and compare the rate of disease progression in SCA1, SCA2, SCA3 and SCA6. Recruitment is ongoing currently 730 participants over 18 years of age have been included.",Ongoing,"0 to 4,999","Prof. Thomas Klockgether","http://www.ataxia-study-group.net/html/studies/eurosca","Email: heike.jacobi@ukb.uni-bonn.de PI email: thomas.klockgether@ukb.uni-bonn.de",,"Dept. of Neurology
University Hospital Bonn
Sigmund-Freud-Str. 25
D-53105 Bonn, Germany","Ataxia Study Group",Ongoing,730,>18,,"Spinocerebellar ataxia (SCA)",,"Condition diagnosed","Austria|Belgium|France|Germany|Hungary|Italy|Netherlands|Spain|United Kingdom",,"0 to 4,999","10 to 19|20 to 39|40 to 59|60 to 100",,"Caregiver|Individual physiological|Individual psychological",Height|Weight,,Blood|Urine,"Gene screening","Magnetic resonance imaging (MRI)",,"Alcohol|Physical activity|Smoking","Housing and accommodation",,"Dept. of Neurology, University Hospital Bonn",
"The Gazel Cohort","The original GAZEL cohort was composed of 20,625 employees of the French national gas and electricity companies (15,011 male employees then aged 40 to 50 years and 5,614 women between 35 and 50 years old) at its inception in 1989.
Follow-up is continuous and includes data collection on health status, lifestyle, and socioeconomic and occupational factors from various sources. A postal questionnaire is sent to the participants each year, and data are extracted regularly from the files of the personnel and medical departments of EDF-GDF and from national registers. Participants were invited in 1999-2000, 2008 and 2011 to a health clinic where medical and biological data were collected.
The main focus of research in the past decade was devoted to the study of the persistent, long-term effects of occupational exposures after retirement; of the transition between professionally active life and retirement; and on determinants of early ageing. Accordingly, in addition to the health, behavioural and social data collected yearly since the beginning of the follow-up, new data were thus collected on cognitive complaints, cognitive and physical functioning, limitations in daily activities, time use and social relationships of retirees.
Last update - 20/06/2017",GAZEL,"GAZEL is a longitudinal cohort which recruited 20,625 participants aged between 35 and 50 from French national gas and electricity companies. The health, social and economic wellbeing of participants has been measured since 1989.",1989,"10,000 to 19,999","Professor Marcel Goldberg","https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2258334/","marcel.goldberg@inserm.fr",+33177747428,"Paris Descartes Medical School - Paris, France","Electricite de France-Gaz de France
Caisse centrale d'action sociale du personnel des industries electrique et gaziere",1989,17500,35-50,,,,"No diagnosis",France,,"20,000 to 49,999","20 to 39|40 to 59","Behaviour|Cognitive function|Mental health|Neurological","Individual psychological","Blood pressure|Height|Hip circumference|Waist circumference|Weight",Cardiovascular|Musculoskeletal|Respiratory,Blood,"Gene screening",,"Consent for brain donation","Alcohol|Dietary habits|Physical activity|Smoking","Education|Family circumstances|Housing and accommodation|Income and finances|Informal support|Marital status|Occupation and employment|Unpaid care","Formal health and social care service utilisation including private care","Inserm UMS 11 - Population-Based Cohort Unit",
"Constances Cohort","The CONSTANCES general-purpose cohort is intended to serve as an epidemiological research infrastructure accessible to the epidemiologic research community with a focus on chronic diseases and aging. CONSTANCES is designed as a randomly selected representative sample of French adults aged 18-69 years at inception; 200,000 subjects will be included over a five-year period. At inclusion, the selected subjects are invited to complete questionnaires and to attend a Health Screening Clinic (HSC) for a comprehensive health examination. A biobank will be set up. The follow-up includes a yearly self-administered questionnaire, and a periodic visit to an HSC. Social and health data are collected from the French national databases. Data collected for participants include social and demographic characteristics, socioeconomic status, life events, behaviors, and occupational factors. The health data cover a wide spectrum: self-reported health scales, reported prevalent and incident diseases, long-term chronic diseases and hospitalizations, sick-leaves, handicaps, limitations, disabilities and injuries, healthcare utilization and services provided, and causes of death. To take into account non-participation at inclusion and attrition throughout the longitudinal follow-up, a cohort of non-participants was set up and will be followed through the same national databases as participants.
Last update - 20/06/2017",,"CONSTANCES is a population cohort focused on chronic diseases and aging. 200,000 subjects between 18-69 will be recruited over a 5 year period which began in 2012.",2012-2019,"100,000 to 499,999","Dr. Marie Zins","http://www.constances.fr/index_EN.php","marie.zins@inserm.fr",+33177747428,"Paris Descartes Medical School - Paris, France","French Agence Nationale de la Recherche",2012-2019,143000,18-69,,,,"No diagnosis",France,,"100,000 to 499,999","10 to 19|20 to 39|40 to 59|60 to 100","Behaviour|Cognitive function|Mental health|Neurological","Individual psychological","Blood pressure|Height|Hip circumference|Waist circumference|Weight",Cardiovascular|Musculoskeletal|Respiratory,Blood,"Gene screening",,"Consent for brain donation","Alcohol|Dietary habits|Physical activity|Smoking","Education|Family circumstances|Housing and accommodation|Income and finances|Informal support|Marital status|Occupation and employment|Unpaid care","Formal health and social care service utilisation including private care","Inserm UMS 11 - Population-Based Cohort Unit",
"Trajectoires epidemiologiques en population","In 2009, when it was launched, the Tempo cohort consisted of 1,103 people between the ages of 22 and 35 who had participated in a study on children and adolescents' health between 1991 and 1999: ""Les Enfants de Gazel"".
In 2011, Tempo cohort expanded to:
- include young people aged 18-25 years who have specific health situations and life situations
- increase the number of participants to study infrequent health problems.
In 2011 1,214 people were interviewed. In 2015, 783 people participated in the study and 533 participants returned a saliva collection kit. Saliva samples allow us to identify genetic markers that are associated with addictive behaviours (tobacco, alcohol and cannabis) in relation to characteristics of people's lives.
In total 526 respondents responded at least three times, and 334 at least four times, giving us the opportunity to examine health trajectories over time.
Participants in the Tempo cohort were asked about their health, the situations they encountered in their daily lives, their work and family experiences.
Last update - 12/05/2017",Tempo,"TEMPO is a population cohort consists of 1,103 22 to 35 year olds who were recruited in 2009. The focus of the study is children and adolescent health.",2009,,"Maria Melchior","http://www.tempo.inserm.fr/","cohorte.tempo@inserm.fr","+33 1 85 56 13 35 or +33 1 85 56 02 40","CoPortal team Tempo iPLESP,
Inserm UMR-S 1136
Campus Saint-Antoine, UPMC, 3eme etage
27 rue de Chaligny
75012 Paris, France","MILDECA
INCA
ANR
Fondation pour la recherche en psychiatrie et en sante mentale
GIS-IReSP
Fondation Pfizer",2009,,22-35,,,,"No diagnosis",France,,"0 to 4,999","0 to 9|10 to 19|20 to 39","Behaviour|Mental health",,Height|Weight,Cardiovascular|Musculoskeletal|Reproductive|Respiratory,Saliva,,,,"Alcohol|Physical activity|Smoking","Education|Family circumstances|Housing and accommodation|Income and finances|Informal support|Marital status|Occupation and employment|Unpaid care","Formal health and social care service utilisation including private care","Health and medical research national institute (Inserm)",
"Sydney Memory and Ageing Study","The Sydney Memory and Ageing Study (Sydney MAS) began in 2005 to examine the clinical characteristics and prevalence of mild cognitive impairment (MCI) and related syndromes, and to determine the rate of change in cognitive function over time.
Non-demented community-dwelling individuals (N=1037) aged 70-90 were recruited from two areas of Sydney, following a random approach to 8,914 individuals on the electoral roll. They underwent detailed neuropsychiatric and medical assessments and donated a blood sample for clinical chemistry, proteomics and genomics. A knowledgeable informant was also interviewed. Structural MRI scans were performed on 554 individuals, and subgroups participated in studies of falls and balance, metabolic and inflammatory markers, functional MRI and prospective memory. The cohort is to be followed up with brief telephone reviews annually, and detailed assessments biannually.
Last update - 20/07/2017","Sydney MAS","Sydney MAS began in 2005 to examine the clinical characteristics of mild cognitive impairment (MCI) and related syndromes, and to determine the rate of change in cognitive function. 1,037 participants aged 70-90 were recruited.",2005-2007,"0 to 4,999","Professor Henry Brodaty","https://cheba.unsw.edu.au/project/sydney-memory-and-ageing-study","k.maston@unsw.edu.au",,"Centre for Healthy Brain Ageing (CHeBA)
NPI, Euroa Centre, Prince of Wales Hospital
Barker Street
Randwick NSW 2031, Australia","National Health and Medical Research Council of Australia",2005-2007,540,70-90,,"Alzheimer's disease|Frontotemporal dementia|Lewy body disease|Mild cognitive impairment (MCI)|Parkinson's disease|Subjective memory complaints (SMC) or subjective cognitive decline (SCD)|Vascular dementia",,"No diagnosis",Australia,,"0 to 4,999","60 to 100","Behaviour|Cognitive function|Mental health|Neurological","Individual psychological","Blood pressure|Height|Hip circumference|Waist circumference|Weight","Cardiovascular|Hearing and Vision|Respiratory",Blood|Saliva,"Gene screening","Magnetic resonance imaging (MRI)","Consent for brain donation","Alcohol|Dietary habits|Physical activity|Smoking","Education|Ethnic group|Housing and accommodation|Informal support|Marital status|Occupation and employment|Unpaid care","Formal health and social care service utilisation including private care","University of New South Wales",
"Singapore Health 2012","Disease follow-up for all the cohorts is conducted by active follow-up every 5 years and linkage to national disease and death registries.
The Singapore Health study is a nationally representative cross-sectional survey with the aim to estimate the prevalence of:

Health conditions of hypertension, hyperlipidaemia, diabetes, overweight and obesity, hearing loss and chronic kidney disease, mental wellbeing and to allow comparison of these data with the National Health Survey 2010;

2,352 Singapore citizens and permanent residents of age 18 to 79 years old participated in the survey from August 2012 to March 2013. Overall response rate was 40%. 1956 of the participants also underwent physical examination, additional surveys and provided blood and urine samples for tests and storage.
Last update - 28/06/2017",SH2012,"SH2012 is a cross sectional survey which began in August 2012 looking at health and lifestyle factors of 2,352 participants, aged 18 to 79. Follow up is conducted every 5 years through record linkage.",2012-2013,,"Associate Professor Rob Martinus van Dam","http://blog.nus.edu.sg/sphs/singapore-health-studies/","ephrmvd@nus.edu.sg",,"Saw Swee Hock School of Public Health
National University of Singapore
Tahir Foundation Building
12 Science Drive 2
#10-01
Singapore 117549","Ministry of Health, Singapore
National University of Singapore
National University Health System, Singapore",2012-2013,,18-79,,"Alzheimer's disease|Parkinson's disease",,"No diagnosis",,,"0 to 4,999","0 to 9|10 to 19|20 to 39|40 to 59|60 to 100","Cognitive function|Mental health|Neurological",,"Blood pressure|Height|Hip circumference|Waist circumference|Weight","Cardiovascular|Hearing and Vision|Musculoskeletal|Reproductive|Respiratory",Blood|Urine,,,,"Alcohol|Dietary habits|Physical activity|Smoking","Education|Ethnic group|Income and finances|Marital status|Occupation and employment","Formal health and social care service utilisation including private care","National University of Singapore",
"Northern Finland Birth Cohort Studies","The Northern Finland Birth Cohort Studies is an epidemiological and longitudinal research program which aims to promote health and well-being of the population. The prospective data collected from the Northern Finland forms a unique resource, allowing to study the emergence of diseases which can be based on genetic, biological, social or behavioural risk factors.
NFBC includes two longitudinal and prospective birth cohorts of women and offspring collected at 20-year intervals from the same provinces of Oulu and Lapland: The NFBC1966 was set with an expected date of birth in 1966, comprising of 12,068 mothers and 12,231 children (prospective data collection from maternity cards since 16th gestational week on average), and the NFBC1986 with an expected date of birth between July, 1st 1985 and June, 30th 1986, comprising 9,362 mothers and 9,479 children (prospective data collection from 10th gestational week).
Last update - 02/05/2017","NFBC1966 and NFBC1987","NFBC 1966 and NFBC 1986 are longitudinal cohort that aim to promote the wellbeing and health of the population. Epidemiological data for over 20,000 mother and over 20,000 children was collected.","NFBC1966: 1965-66|NFBC1987: 1985-86","10,000 to 19,999|20,000 to 49,999","Minna Mannikko and Marjo-Riitta Jarvelin","http://www.oulu.fi/nfbc/","PI Email: minna.mannikko@oulu.fi PI Email: tuula.ylitalo@oulu.fi Contact Email: NFBCprojectcenter@oulu.fi","Minna Mannikko, NFBC Research DirectorPhone number: +358 (0) 294485751 Int. 485751Email: minna.mannikko@oulu.fiProject secretary: Tuula YlitaloPhone number: +358 (0) 294 485659 Int. 485659",,"University of Oulu","NFBC1966: 1965-66NFBC1987: 1985-86","NFBC1966: 11,993 mothers/11,907 childrenNFBC1986: 9,098 mothers/9,421 children",>0,,,,"No diagnosis",Finland,,"20,000 to 49,999","0 to 9|10 to 19|20 to 39|40 to 59","Behaviour|Cognitive function|Mental health|Neurological",Caregiver,"Blood pressure|Height|Hip circumference|Waist circumference|Weight","Cardiovascular|Hearing and Vision|Musculoskeletal|Reproductive|Respiratory","Blood|Cerebral spinal fluid (CSF)|CSF biomarker data available|Microbiome|Other|Saliva|Urine","Gene screening","Magnetic resonance imaging (MRI)",,"Alcohol|Dietary habits|Physical activity|Smoking","Education|Family circumstances|Housing and accommodation|Income and finances|Marital status|Occupation and employment","Formal health and social care service utilisation including private care","Northern Finland Birth Cohorts Project Center at the Medical Faculty, University of Oulu",
"The InveCe.Ab (Brain Ageing in Abbiategrasso) Study","InveCe.Ab (Invecchiamento Cerebrale ad Abbiategrasso) is a longitudinal, population-based study of disorders of brain ageing involving the assessment and long-term monitoring of the physical conditions and cognitive status. The target population comprises all Abbiategrasso residents born between 1935 and 1939, a reference sample, according to Population Register data, of around 1,700 people.
Those who agreed to participate in the Invece.Ab study were enrolled in a cross-sectional assessment and will be contacted two and four years after the initial data collection to participate in the longitudinal survey. Both the cross-sectional and longitudinal assessments include a medical evaluation, a neuropsychological test battery, several anthropometric measurements, a social and lifestyle interview, blood analyses, and the storage of a blood sample for the evaluation of putative biological markers.
Last update - 02/05/2017",InveCe.Ab,"InveCe Ab is a longitudinal study of disorders of brain ageing. Between 2009-2014 1,700 Abbiatehrasso residences born between 1935-1939 were recruited.",2009-2014,"0 to 4,999","Dr Antonio Guaita","http://www.golgicenci.it/en/studio-invece/","Email: d.zaccaria@golgicenci.it PI Email:a.guaita@golgicenci.it",,"Golgi Cenci Foundation
Abbiategrasso
Milan, IT","Federazione Alzheimer Italia",2009-2014,1010,70-74,,"Alzheimer's disease|Frontotemporal dementia|Lewy body disease|Mild cognitive impairment (MCI)|Other NDs not listed|Subjective memory complaints (SMC) or subjective cognitive decline (SCD)|Vascular dementia",,"No diagnosis",Italy,,"0 to 4,999","60 to 100","Cognitive function|Mental health|Neurological","Individual psychological","Blood pressure|Height|Hip circumference|Waist circumference|Weight","Cardiovascular|Hearing and Vision|Reproductive|Respiratory",Blood,"Gene screening",,"Consent for brain donation","Alcohol|Dietary habits|Physical activity|Smoking","Education|Housing and accommodation|Income and finances|Informal support|Marital status|Occupation and employment|Unpaid care",,"Golgi Cenci Foundation",
"Canadian Longitudinal Study on Aging","The CLSA will collect information on the changing biological, medical, psychological, social, lifestyle and economic aspects of people's lives across Canada. These factors will be studied to understand how, individually and in combination, they have an impact in both maintaining health and in the development of disease and disability as people age
A total of 21,241 people from across Canada have agreed to take part in a telephone interview, once every three years.
An additional 30,097 people consented to participate in an in-home interview, and a visit to one of 11 Data Collection Sites across Canada where they take part in a range of physical assessments.
These participants were selected randomly, and were aged 45 to 85 when first contacted. The interviews and visits will take place once every three years over the 20-year course of the study
The study has entered its next phase where each individual recruited between 2010 and 2015 (baseline) will be re-contacted for the first follow-up. This will be conducted between 2015 and 2018. During this phase, the CLSA research team will collect the same type of information that was collected at baseline, along with several new measures that have been introduced.
Last update - 12/05/2017",CLSA,"CLSA is a population cohort looking at variables which impact on maintaining health and in the development of disease and disability as people age. Around 50,000 participants were recruited between the age of 45-85 starting in 2010.",2010-2015,"20,000 to 49,999","Professor Parminder Raina","https://www.clsa-elcv.ca/","info@clsa-elcv.ca",1-866-999-8303,"Canadian Longitudinal Study on Aging (CLSA)
National Coordinating Centre
1280 Main St W. MIP-309A
Hamilton ON L8S 4K1","CIHR and the Canada Foundation for Innovation|provincial governments of British Columbia, Alberta, Manitoba, Ontario, Quebec, Nova Scotia and Newfoundland and Labrador",2010-2015,48771,45-85,,"Alzheimer's disease|Parkinson's disease",,"No diagnosis",Canada,,"50,000 to 99,999","40 to 59|60 to 100",,"Caregiver|Individual physiological|Individual psychological","Blood pressure|Height|Hip circumference|Waist circumference|Weight","Cardiovascular|Hearing and Vision|Musculoskeletal|Reproductive|Respiratory",Blood|Urine,,"Electroencephalogram (EEG)",,"Alcohol|Dietary habits|Physical activity|Smoking","Education|Ethnic group|Family circumstances|Housing and accommodation|Income and finances|Informal support|Marital status|Occupation and employment|Unpaid care","Formal health and social care service utilisation including private care","Dalhousie University|McGill University|McMaster University|Memorial University|Ottawa University|Simon Fraser University|Universite de Sherbrooke|University of British Columbia|University of Calgary|University of Manitoba|University of Victoria",
"The Airwave Health Monitoring Study","The Airwave Health Monitoring Study was established to evaluate possible health risks associated with the use of TETRA, a digital communication system used by the police forces and other emergency services in Great Britain since 2001. It is a long-term observational study following up the health of the police force with respect to TETRA exposure, and ability to monitor both cancer and non-cancer health outcomes. Around 53,000 participants have been recruited between 2004 and 2015.
Last update - 05/05/2017",Airwave,"Airwave is a long-term observational study following up the health of the police force with respect to TETRA exposure. 53,000 participants, over 16, have been recruited between 2004 and 2015.",2004-2017,"50,000 to 99,999","Professor Paul Elliot","http://www.police-health.org.uk/","a.vergnaud@imperial.ac.uk",02075942556,"Department of Epidemiology and Biostatistics School of Public Health,
Imperial College Faculty of Medicine,
Norfolk Place,
London,
W2 1PG","Home Office | National Institute for Health Research (NIHR)",2004-2017,53000,>16,,"Parkinson's disease",,"No diagnosis","United Kingdom",,"50,000 to 99,999","10 to 19|20 to 39|40 to 59|60 to 100","Cognitive function|Mental health|Neurological","Individual psychological","Blood pressure|Height|Hip circumference|Waist circumference|Weight",Cardiovascular,Blood|Urine,"Gene screening",,,"Alcohol|Dietary habits|Physical activity|Smoking","Education|Ethnic group|Family circumstances|Housing and accommodation|Income and finances|Marital status|Occupation and employment","Formal health and social care service utilisation including private care","Imperial College London",
"The European Prospective Investigation into Cancer and Nutrition","The European Prospective Investigation into Cancer and Nutrition (EPIC) is a prospective cohort with more than 521,000 study participants enrolled from 23 centres in 10 western European countries. Detailed information on diet, lifestyle characteristics, anthropometric measurements, and medical history was collected at recruitment (1992-1999).
Biological samples including plasma, serum, leukocytes, and erythrocytes were also collected at baseline from 387,889 individuals and are stored at the International Agency for Research on Cancer - World Health Organization (IARC-WHO) and mirrored at EPIC collaborating centres. Overall, the EPIC biorepositories host more than 9 million aliquots, constituting one of the largest biobanks in the world for biochemical and genetic investigations on cancer and other chronic diseases. Follow-up measures of lifestyle exposures have been collected and will be centralized at IARC in 2016.
Last update - 25/04/2017",EPIC,"EPIC is a prospective cohort with 521,000 participants which began in 1992. Detailed information on diet, lifestyle characteristics, anthropometric measurements, medical history and biological samples were collected at recruitment.",1992-99,,"Professor Elio Riboli, Dr Marc Gunter and Dr Paul Brennan","http://epic.iarc.fr/","epic@iarc.fr","33 (0)4 72 73 84 85","IARC,
150 Cours Albert Thomas,
69372 Lyon
CEDEX 08,
France","World Health Organisation (WHO)",1992-99,,,,"Dementia (unclassified)|Frontotemporal dementia|Motor neurone disease|Parkinson's disease",,"No diagnosis","Denmark|France|Germany|Greece|Italy|Netherlands|Norway|Spain|Sweden|United Kingdom",,"500,000+",,,,"Blood pressure|Height|Hip circumference|Waist circumference|Weight",Reproductive,Blood,"Gene screening",,"Consent for brain donation","Alcohol|Dietary habits|Physical activity|Smoking","Education|Income and finances|Marital status|Occupation and employment","Formal health and social care service utilisation including private care",Multiple,
"The European Male Ageing Study","This is the largest multi-centre study of ageing in men in the world and intends to identify the nature and frequency of some of the symptoms of ageing in men, the relationships between these symptoms to hormonal changes and other risk factors.
In total, 3369 men in 8 different countries in Europe are taking part in the study. These 8 centres are Manchester - UK, Malmo - Sweden, Tartu - Estonia, Lodz - Poland, Szeged - Hungary, Florence - Italy, Santiago de Compostela - Spain, Leuven - Belgium. In each centre, ~400 men aged between 40 and 79 years at the start of the study have been recruited. They will be followed up to look for future changes in their hormonal and general health status. The men will be investigated initially on two occasions, at the start and then ~5 years later. It is highly likely that the study will continue beyond 5 years and further testing will be organised subsequently. The aims of the study are to:

Document geographical variations in the ageing-related involution decline of endocrine function in European men;

Explain the variability in the rate of secular decline in endocrine functions on the basis of socio-demographic, lifestyle, co-morbid, ethnic/racial, or genetic factors;

Predict the physical and psychological health status of individuals based on the variation in ageing-related endocrine decline and changes in body composition.

Last update - 24/04/2017",EMAS,"EMAS is a population study that intends to identify the nature and frequency of some of the symptoms of ageing in men. 3,369 men aged between 40 and 79 were recruited between 2003/09.",2003-09,"0 to 4,999",Multiple,"http://www.emas.man.ac.uk/Main.asp","michelle.reading@manchester.ac.uk","+44 161 901 1825","European Male Ageing Study
Andrology Research Unit
Division of Endocrinology, Diabetes & Gastroenterology
Domain of Cardiovascular, Metabolic and Nutritional Sciences
School of Medical Sciences
Faculty of Biology, Medicine and Health
University of Manchester (United Kingdom)
Manchester Academic Health Science Centre
Old St Mary's Building - Ground Floor
Hathersage Road
M13 9WL
Manchester
United Kingdom","Commission of the European Communities",2003-09,3369,40-79,,,,"No diagnosis","Belgium|Estonia|Hungary|Italy|Poland|Spain|Sweden|United Kingdom",,"0 to 4,999","40 to 59|60 to 100","Behaviour|Cognitive function|Mental health|Neurological","Individual physiological","Blood pressure|Height|Hip circumference|Waist circumference|Weight","Cardiovascular|Hearing and Vision|Musculoskeletal|Reproductive",Blood,,,,"Alcohol|Dietary habits|Physical activity|Smoking","Education|Ethnic group|Marital status|Occupation and employment","Formal health and social care service utilisation including private care",Multiple,
"The 1982 Pelotas (Brazil) Birth Cohort Study","Initially, the study focus was on perinatal, infant, and early childhood morbidity and mortality. We were particularly interested in breastfeeding patterns and nutritional status, as well as social and environmental factors. Deaths of cohort members were identified by regular visits to all hospitals, cemeteries, offices of civil registrations, and local health authorities, since 1982.
By mid-childhood, the study shifted in emphasis to child care, utilization of health services, selected morbidity indicators, and child development. A random sub-sample of 360 four-year-olds was selected for an in-depth study of psychomotor development.
In adolescence, issues related to sexual and reproductive behaviours (including teenage pregnancies), habits such as smoking and alcohol drinking, mental health, and education became the focus of the investigation. A sub-study investigated oral health in a random sample of 900 adolescents, and an ethnographic study of 96 cohort members, stratified by sex and socioeconomic status, has included repeated in-depth visits from the age of 15 to 30 years, aimed at understanding the role of adolescent development in influencing high-risk behaviours.
In more recent phases, with cohort members being young adults, the main emphasis has shifted to risk factors for chronic disease (including smoking, diet, physical exercise, and overweight), reproductive history, and mental health.
Last update - 21/06/2017",,"The 1982 Pelotas birth cohort study has evolved since conception in 1982. In the latest phase it is focused on risk factors for chronic diseases, reproductive history and mental health.",1982,"0 to 4,999","Professor Fernando Barros, Professor Cesar Victora and Bernardo Lessa Horta","http://epidemio-ufpel.org.br/site/content/coorte_1982/index.php","blhorta@gmail.com","55 (53) 3284 - 1300","Rua Marechal Deodoro, 1160 - 3ﾰ Piso
Bairro Centro - Pelotas, RS
Cep: 96020-220 - Caixa Postal 464","World Health Organization (WHO)
Wellcome Trust
Brazilian Research Council (CNPq)",1982,3701,0,,,,"No diagnosis",Brazil,,"0 to 4,999","0 to 9|10 to 19|20 to 39","Cognitive function|Mental health",,"Height|Waist circumference|Weight",Cardiovascular|Musculoskeletal|Reproductive|Respiratory,Blood,"Gene screening",,,"Alcohol|Dietary habits|Physical activity|Smoking","Education|Family circumstances|Housing and accommodation|Income and finances|Informal support|Marital status|Occupation and employment","Formal health and social care service utilisation including private care","Universidade Federal de Pelotas",
"TRACK-HD and TrackOn-HD","TRACK-HD was a prospective observational biomarker study in participants with premanifest and early Huntington's disease (HD). Track-HD assessed longitudinal data collected at baseline, 12 months, 24 and 36 months at sites in Leiden (Netherlands), London (UK), Paris (France), and Vancouver (Canada). Participants were individuals without HD but carrying the mutant HTT gene (ie, premanifest HD), patients with early HD, and healthy control individuals matched by age and sex to the combined HD groups. Data were collected with 3T MRI, clinical, cognitive, quantitative motor, oculomotor, and neuropsychiatric assessments. TrackOn-HD followed on from TRACK-HD aiming to investigate compensatory mechanisms in premanifest gene carriers. Baseline, 12 and 24 month data was collected from the same four sites on premanifest gene carriers and healthy controls including 3T MRI, task and resting state fMRI, DTI, clinical, cognitive, quantitative motor and neuropsychiatric assessments.
Last update - 11/04/2017",,"TRACK HD was the forerunning cohort of TrackOn, both focused on participants with premanifest and early HD. 366 gene carriers were recruited as part of TRACK HD between 2012-2014 aged of 18-65.",2008-2011|2012-2014,"0 to 4,999","Professor Sarah Tabrizi","http://hdresearch.ucl.ac.uk/completed-studies/trackon-hd/http://hdresearch.ucl.ac.uk/our-results/track-hd/","andrew.wood@chdifoundation.org| PI Email: s.tabrizi@ucl.ac.uk",609-945-9586,"CHDI Management, Inc.
155 Village Boulevard, Suite 200
Princeton, NJ 08540
Office: 609-945-9586","CHDI Foundation","Phase 1: 2008-2011 Phase 2: 2012-2014",430,18-65,,"Dementia (unclassified)|Huntington's disease|Other NDs not listed|Subjective memory complaints (SMC) or subjective cognitive decline (SCD)",,"Condition diagnosed","United Kingdom",,"0 to 4,999","10 to 19|20 to 39|40 to 59|60 to 100","Behaviour|Cognitive function|Mental health|Neurological","Individual physiological|Individual psychological",Height|Weight,"Cardiovascular|Hearing and Vision",Blood,"Gene screening","Magnetic resonance imaging (MRI)|Single photon emission computerised tomography (SPECT)",,Alcohol|Smoking,"Education|Ethnic group|Housing and accommodation|Occupation and employment",,"University College, London",
"The Norwegian ParkWest Study","The Norwegian ParkWest study is a prospective population-based longitudinal cohort study of patients with incident Parkinson's Disease in Western and Southern Norway, with a total base population of more than 1 million inhabitants. The initial cohort comprised of 212 newly-diagnosed and drug-naïve individuals with suspected Parkinson's disease, who were followed with standardized clinical examinations every 6 months. More comprehensive assessments, including neuropsychological and behavioural evaluations, were conducted at baseline and 1-year of follow-up, and at 2-year intervals thereafter. Currently, study participants are in the 10th year of follow-up. About 110 patients are still in the study.
Last update - 10/04/2017",ParkWest,"ParkWest is a prospective cohort study of patients with incidents of PD in Norway. 212 participants over 18 years of age were recruited between 2004 and 2006.",2004-2006,"0 to 4,999","Professor Guido Alves|Professor Ole-Bjorn Tysnes","http://www.parkvest.no/","Email: nkb@sus.no|algu@sus.no| PI Email: Ole-Bjorn.Tysnes@uib.no","+47 51 51 52 18","The Norwegian Centre for Movement Disorders
Stavanger University Hospital
PO Box 8100
4068 Stavanger
Norway","Norwegian Parkinson Research Foundation
Western Norway Regional Health Authority
Research Council of Norway",2004-2006,110,>18,,"Parkinson's disease",,"Condition diagnosed",Norway,,"0 to 4,999","10 to 19|20 to 39|40 to 59|60 to 100","Behaviour|Cognitive function|Mental health|Neurological","Caregiver|Individual physiological|Individual psychological",Height|Weight,,"Blood|Cerebral spinal fluid (CSF)","Gene screening","Magnetic resonance imaging (MRI)","Consent for brain donation",Alcohol|Smoking,"Education|Ethnic group|Family circumstances|Housing and accommodation|Marital status|Occupation and employment|Unpaid care",,"Stavanger University Hospital",
"Southall and Brent Revisited","The Southall And Brent Revisited Study (SABRE) is the largest tri-ethnic population-based cohort in the UK, involving nearly 5000 European, Indian Asian and African Caribbean men and women. It investigates the causes of diabetes and disorders of the heart and circulation and examines underlying reasons for ethnic differences in risk of these disorders.
The participants were aged 40-69 when first studied between 1989 and 1991. In 2008-2011 a comprehensive combined morbidity and mortality follow up was carried out, together with non-invasive clinical measurements in order to quantify sub-clinical disease. SABRE visit 2 tested hypotheses generated from the Southall and Brent baseline studies and ongoing mortality follow-up.
SABRE Visit 3 (25 year follow-up visit) started in July 2014 and is collecting data on index participants and new participants, including partners of index participants. The focus of this visit is on cardiac, cognitive and physical function in older age, in association with mid-life risk factors. Ethnic and gender differences in function will also be examined.
Last update - 10/04/2017",SABRE,"SABRE is a population based cohort looking at the reasons for ethnic differences in risk of developing heart disorders or diabetes. 4,858 ethnically diverse participants aged betweem 40-69 were recruited in 1989.",1988,"0 to 4,999","Professor Nish Chaturvedi","http://www.sabrestudy.org","Email: sabre@ucl.ac.uk| PI Email: n.chaturvedi@ucl.ac.uk","02076 799471","UCL Institute of Cardiovascular Science,
Gower Street,
London,
WC1E 6BT","Wellcome Trust
British Heart Foundation",1988,2572,40-69,,,,"No diagnosis","United Kingdom",,"0 to 4,999","40 to 59|60 to 100","Cognitive function|Mental health|Neurological","Caregiver|Individual physiological|Individual psychological","Blood pressure|Height|Hip circumference|Waist circumference|Weight","Cardiovascular|Hearing and Vision|Musculoskeletal|Respiratory",Blood|Saliva|Urine,"Gene screening","Magnetic resonance imaging (MRI)",,"Alcohol|Dietary habits|Physical activity|Smoking","Education|Ethnic group|Family circumstances|Housing and accommodation|Income and finances|Informal support|Marital status|Occupation and employment|Unpaid care","Formal health and social care service utilisation including private care","University College, London",
"Caerphilly Prospective Study","The initial aims were to examine the importance of lipids, haemostatic factors, and hormones such as testosterone, cortisol and insulin (Lichtenstein et al 1987) in the development of ischaemic heart disease (IHD). Subsequently, other hypotheses were included with a specific interest in platelet function, and psychosocial variables. With the ageing of the cohort, additional outcomes have been included in particular stroke, hearing problems and cognitive function.
The initial design attempted to contact all men aged 45 to 59 years from the town of Caerphilly and adjoining villages. 2512 subjects (response rate 89%) identified from the electoral register and general practice lists were examined between July 1979 until September 1983 (phase I).
Men were initially seen at an evening clinic, where they completed a questionnaire, had anthropometric measures and an ECG taken. They also completed a food frequency questionnaire at home (Fehily et al 1994). They subsequently re-attended an early morning clinic to have fasting blood samples for a wide variety of tests.
Quality control was examined by the use of both ""blind"" split samples as well as a second repeat measure on a random sub-sample to examine intra-individual variation.
The men have been followed up 5 times; Phase II (July 1984-June 1988), Phase III (Nov 1989-Sep 1993), Phase IV (Oct 1993-Feb 1997) and two further occasions via post. An additional 447 men were included in the survey at Phase II.
Last update - 11/04/2017",CAPS,"CAPS is a population cohort which began in 1987 to examine haemostatic factors in the development of Ischaemic heart disease. 2,512 men age of 45 to 59 were recruited and have been contacted 5 times.",1979-1983,"0 to 4,999","Professor Yoav Ben-Shlomo","http://www.bris.ac.uk/social-community-medicine/projects/caerphilly/","Y.Ben-Shlomo@bristol.ac.uk",,"Professor Yoav Ben-Shlomo
School of Social and Community Medicine
University of Bristol
Canynge Hall
39 Whatley Road
Bristol, BS8 2PS
United Kingdom",,1979-1983,2959,>45,,"Alzheimer's disease|Mild cognitive impairment (MCI)|Parkinson's disease|Vascular dementia",,"No diagnosis","United Kingdom",,"0 to 4,999","40 to 59|60 to 100","Cognitive function|Mental health|Neurological","Individual psychological","Blood pressure|Height|Hip circumference|Waist circumference|Weight","Cardiovascular|Hearing and Vision|Respiratory",Blood|Saliva,"Gene screening",,,"Alcohol|Dietary habits|Physical activity|Smoking","Education|Housing and accommodation|Informal support|Marital status|Occupation and employment","Formal health and social care service utilisation including private care","University of Bristol",
"Prospective study of individuals at risk for spinocerebellar ataxia type 1, type 2, type 3 and type 6 (SCA1, SCA2, SCA3, SCA6)","The aim of RISCA is to answer the following questions:

What is the incidence of disease manifestation in mutation carriers?

Which clinical signs precede the onset of manifest ataxia in SCA1, SCA2, SCA3 and SCA6?

What are the prevalence and incidence of preceding signs?

Are the prevalence and incidence of preceding signs affected by genotype, gender, age, estimated time until disease manifestation and repeat length?

Does the presence of certain preceding signs predict the manifestation of ataxia?

Are there MRI alterations that precede the onset of ataxia?

Study participants are followed at 24 months intervals over six years and than at irregular intervals. At each visit, study participants are asked in a structured interview for a number of predefined clinical signs that potentially precede the onset of ataxia.
Last update - 26/05/2017 ",RISCA,"RISCA focuses on the clinical signs that precede the onset of manifest ataxia in SCA1, SCA2, SCA3 and SCA6. 480 participants over 18 have been recruited.",,"0 to 4,999","Prof. Dr Thomas Klockgether","http://www.ataxia-study-group.net/html/studies/risca?clps1708_1624951375=1","heike.jacobi@ukb.uni-bonn.de",,"Dept. of Neurology
University Hospital Bonn
Sigmund-Freud-Str. 25
D-53105 Bonn, Germany","E-Rare program",,300,>18,,"Spinocerebellar ataxia (SCA)",,"At-risk diagnosis",Germany,,"0 to 4,999","0 to 9|10 to 19|20 to 39|40 to 59","Cognitive function|Mental health","Individual physiological|Individual psychological",Height|Weight,,Blood|Urine,,,,"Alcohol|Physical activity|Smoking",,,,
"Parkinsonism Incidence in the North-East Scotland Study","The aim of the study was to determine the incidence of Parkinson's disease and other degenerative / vascular parkinsonian disorders in a defined geographical area in the North-East of Scotland and to describe the long-term prognosis of patients and carers in an incident cohort compared to age-sex matched community controls.
Ascertainment:

Referrals from GPs

Referrals from hospital consultants

Hand-searching referral letters (neurology & DOME)

Electronic searching (GP, hospital discharge data)

Screening over 65 and over 75's

Annual follow-up plus linked to death register.
Last update - 08/03/2017",PINE,"The aim of the study is to determine the incidence of Parkinsons disease and other parkinsonian disorders in a defined geographical area. PINE began in 2006 recruiting 1210 participants with a mean age of 72.",2006-09,,"Dr Carl Counsell","http://www.abdn.ac.uk/iahs/research/chronic-disease/neurology-253.php","carl.counsell@abdn.ac.uk",,"Institute of Applied Health Sciences
University of Aberdeen
Foresterhill
Aberdeen
AB25 2ZD","Parkinsons UK|NHS Grampian Endowments|NHS Grampian Research and Development dept|BMA award, RS Macdonald Trust|BUPA Foundation.",2006-09,,72,,"Lewy body disease|Other NDs not listed|Parkinson's disease|Subjective memory complaints (SMC) or subjective cognitive decline (SCD)",,"At-risk diagnosis","United Kingdom",,"0 to 4,999","60 to 100","Cognitive function|Mental health|Neurological","Caregiver|Individual physiological|Individual psychological","Blood pressure|Height|Weight",,Blood,"Gene screening",,"Consent for brain donation",Alcohol|Smoking,"Education|Ethnic group|Family circumstances|Housing and accommodation|Marital status|Occupation and employment|Unpaid care","Formal health and social care service utilisation including private care","Aberdeen University",
"National Longitudinal Study of Adolescent to Adult Health","The original purpose of the Add Health study was to help understand the causes of adolescent health and health behaviour with special emphasis on the effects of multiple contexts of adolescent life.
The cohort was then followed through their transition to adulthood and research turned to understanding the determinants and consequences of developmental and health trajectories from adolescence into adulthood.
Add Health combines longitudinal survey data on respondents social, economic, psychological and physical well-being with contextual data on the family, neighbourhood, community, school, friendships, peer groups, and romantic relationships, providing unique opportunities to study how social environments and behaviours in adolescence are linked to health and achievement outcomes in young adulthood. The fourth wave of interviews expanded the collection of biological data in Add Health to understand the social, behavioural, and biological linkages in health trajectories as the Add Health cohort ages through adulthood, and the fifth wave of data collection continues this biological data expansion (2016-2018).
Last update - 03/02/2017","Add Health","Add Health is a population cohort recruiting 20,745 participants in Grades 7-12. It is now on its fifth wave where is has added biological data to the original social, economic and psychological data to the original study.",1994-95,"10,000 to 19,999","Professor Kathleen Mullan Harris","http://www.cpc.unc.edu/projects/addhealth","Email: addhealth@unc.edu Project Co-ordinator Email: sarah.dean@unc.edu and kathryn_carrier@unc.edu PI Email: kathie_harris@unc.edu",,"Add Health
Carolina Population Center
University of North Carolina at Chapel Hill, CB# 8120
206 West Franklin Street
Chapel Hill, NC 27516","Eunice Kennedy Shriver National Institute of Child Health and Human Development
National Cancer Institute
National Center for Health Statistics, Centers for Disease Control and Prevention, DHHS
National Center for Injury Prevention and Control, Centers for Disease Control and Prevention, DHHS
National Center for Minority Health and Health Disparities
National Institute of Allergy and Infectious Diseases
National Institute on Deafness and Other Communication Disorders
National Institute of General Medical Sciences
National Institute of Mental Health
National Institute of Nursing Research
National Institute on Aging
National Institute on Alcohol Abuse and Alcoholism
National Institute on Drug Abuse
National Science Foundation
Office of AIDS Research, NIH
Office of the Assistant Secretary for Planning and Evaluation, DHHS
Office of Behavioral and Social Sciences Research, NIH
Office of the Director, NIH
Office of Minority Health and Health Disparities, Centers for Disease Control and Prevention, DHHS
Office of Minority Health, Office of Public Health and Science, DHHS
Office of Population Affairs, DHHS
Office of Research on Women's Health, NIH
MacArthur Foundation
Robert Wood Johnson Foundation",1994-95,19828,7-12,,,,"No diagnosis","United Kingdom",,"20,000 to 49,999","10 to 19|20 to 39|40 to 59|60 to 100","Behaviour|Cognitive function|Mental health|Neurological","Individual psychological","Blood pressure|Height|Waist circumference|Weight","Cardiovascular|Hearing and Vision|Reproductive",Blood|Other|Saliva|Urine,"Gene screening",,,"Alcohol|Dietary habits|Physical activity|Smoking","Education|Ethnic group|Family circumstances|Housing and accommodation|Income and finances|Informal support|Marital status|Occupation and employment","Formal health and social care service utilisation including private care","University of North Carolina at Chapel Hill",
"Alzheimer’s Disease Neuroimaging Initiative","ADNI began in October 2004. The overall goal is to validate biomarkers for Alzheimer's disease clinical trials. One aim is to find, validate and standardize more sensitive and accurate methods to detect Alzheimer's disease at earlier stages and mark its progress through biomarkers. The study gathered and analyzed thousands of brain scans, genetic profiles, and biomarkers in blood and cerebrospinal fluid that are used to measure the progress of disease or the effects of treatment. More information on ADNI-info.org. All data is publically available at USC/LONI/ADNI.
The three overarching longitudinal ADNI study goals are:

Validation of biomarkers, especially for amyloid and tau, for use in AD clinical trials.

To detect Alzheimer's disease (AD) at the earliest stage possible and identify ways to track the disease through biomarkers.

To support advances in AD intervention, prevention and treatment through the application of new diagnostic methods to apply at the earliest stages technically possible - when intervention may be most effective.

To find out the known as well as some new factors which increase the risk of occurrence of stroke (half body paralysis, Lakwa) and of memory problem and other brain related problems.

To identify a group of apparently healthy people (50 years and above), carry out their health check up and follow them up over several years to detect any health problems (like heart attack, lakwa, memory problems) with increasing age.

To investigate the prevalence and incidence of and risk factors for stroke and cognitive decline in the elderly.

Updates about the health of the participants will be obtained from telephone follow-ups every six months and physical check-ups every three years. The study is expected to last for at least 10 years.
Last update - 02/02/2017","AIIMS Cohort Study","The AIIMS Cohort is a population study which began in 2014, recruiting 15,000 participants over 50 years old. The objective is to identify factors which increase the risk of strokes, memory problems and other brain related problems.",2015-18,"10,000 to 19,999","Professor Kameshwar Prasad","http://aiimscohortstudy.in","aiimscohortstudy@gmail.com","+91 11-26594013","AIIMS Cohort Study Center,
All India Institute of Medical Sciences,
Ansari Nagar,
New Delhi- 110029
India","Department of Biotechnology
Ministry of Science & Technology
Government of India",2015-18,15000,>50,,"Alzheimer's disease|Dementia (unclassified)|Frontotemporal dementia|Mild cognitive impairment (MCI)|Other NDs not listed|Subjective memory complaints (SMC) or subjective cognitive decline (SCD)|Vascular dementia",,"No diagnosis",India,,"10,000 to 19,999","40 to 59|60 to 100","Cognitive function|Mental health|Neurological","Individual psychological","Blood pressure|Height|Hip circumference|Waist circumference|Weight","Cardiovascular|Hearing and Vision|Musculoskeletal|Reproductive|Respiratory",Blood|Saliva,"Gene screening","Magnetic resonance imaging (MRI)",,"Alcohol|Dietary habits|Physical activity|Smoking","Education|Ethnic group|Family circumstances|Housing and accommodation|Income and finances|Informal support|Marital status|Occupation and employment",,"India Institute of Medical Sciences",
"Amyloid imaging for phenotyping lewy body dementia","The AMPLE study has been set up to investigate differences and outcomes in those with Lewy body dementia with and without concurrent Alzheimer's disease/pathology. The principle aim of AMPLE is to undertake amyloid PET imaging in Lewy Body Dementia (LBD) and Alzheimer's disease (AD) of 80 participants over the age of 60 and investigate the distribution of amyloid burden in LBD relative to AD and controls at baseline. A further aim is to determine the relationship between amyloid levels at baseline, clinical features of the disease, other imaging changes and subsequent clinical course in follow up.
Primary analysis would divide LBD patients into high and low amyloid burden with participants then compared on clinical features with AD-like symptoms and cognitive profiles. Follow up will be completed annually through surveys and clinical examinations.
Last update - 01/02/2017",AMPLE,"AMPLE is disease specific cohort which recruited in 2013 80 participants with Lewy body dementia with and without concurrent Alzheimers disease/pathology. Its aim is to investigate the distribution of amyloid burden in LBD relative to AD.",2013,,"Professor John O'Brien","http://www.ncl.ac.uk/caru/research/project/5055","n.a.barnett@newcastle.ac.uk;M.J.Firbank@ncl.ac.uk","+44 (0) 191 208 1322","Clinical Ageing Research Unit, Campus for Ageing and Vitality, Newcastle upon Tyne, NE4 5PL","NIHR Newcastle Biomedical Research Unit|Avid",2013,,>60,,"Alzheimer's disease|Lewy body disease",,"Condition diagnosed","United Kingdom",,"0 to 4,999","60 to 100","Behaviour|Cognitive function|Mental health","Individual physiological|Individual psychological",,"Cardiovascular|Hearing and Vision","Blood|Cerebral spinal fluid (CSF)","Gene screening","Magnetic resonance imaging (MRI)|Positron emission tomography (PET) fluorine18 flurodeoxyglucose (FDG)",,Alcohol|Smoking,Education,,"Newcastle University",
"Cognitive Function and Ageing Studies Wales","CFAS Wales aims to interview a representative sample of 3,750 people aged 65 and over in two areas in Wales (Gwynedd and Swansea). Using established and standardised techniques it will collect data that will enable the investigation of cognitive impairment, depression, physical disability and healthy active life expectancy for the whole group and within social groups. It will provide a foundation for other collaborative studies that investigate biomarkers and other early indications of risk of cognitive decline, such as imaging. It will investigate factors that may delay the onset of dementia, specifically focussing on the role of bilingualism and social networks. As the participants reside in a bilingual area this is a key opportunity.
Last update - 13/02/2017","CFAS Wales","CFAS Wales is a population study of over 3,750 people aged 65 and over. It began in 2011 and focuses on cognitive impairment, depression, physical disability and a healthy active life within the participants.",2011,"0 to 4,999","Professor Robert Woods","http://www.cfas.ac.uk/cfas-wales/","PI Email: b.woods@bangor.ac.uk",,,"Economic and Social Research Council
Higher Education Funding Council for Wales",2011,3500,>65,,"Alzheimer's disease|Dementia (unclassified)|Mild cognitive impairment (MCI)|Parkinson's disease",,"No diagnosis","United Kingdom",,"0 to 4,999","60 to 100","Behaviour|Cognitive function|Mental health|Neurological","Individual physiological|Individual psychological",Weight,"Cardiovascular|Hearing and Vision|Musculoskeletal|Reproductive|Respiratory",Saliva,,,,"Alcohol|Dietary habits|Physical activity|Smoking","Education|Ethnic group|Family circumstances|Housing and accommodation|Income and finances|Informal support|Marital status|Occupation and employment|Unpaid care","Formal health and social care service utilisation including private care","Bangor University",
"Danish 1905 Cohort Study","The overall goal was to establish a genetic-epidemiological database to shed light on the aging process among the extremely old, focusing on physical and cognitive functioning. In the first wave 2,262 Danes born in 1905 participated in a home-based 2-hour multidimensional interview, including cognitive and physical performance tests and collection of DNA, carried out by lay interviewers. Population-based registers were used to evaluate representativeness.
The first wave took place in 1998 and participants were followed-up in 2000 and 2003. In 2005 all the surviving birth cohort members were invited to participate irrespective of previous participation:

Wave 1: 2262 participants (1653 with biological sample)

Wave 2: 1086 participants

Wave 3: 437 participants

Wave 4: 256 participants

Last update - 30/01/2017",DCS-1905,"DCS began in 1905 and focused on physical and cognitive functioning in the extremely old (92-100). 2,262 Danes were selected in 1998 through population-based registers.",1998-2005,"0 to 4,999","Professor Kaare Christensen and Professor Bernard Jeune","http://www.icpsr.umich.edu/icpsrweb/NACDA/studies/3960","PI Email: kchristensen@health.sdu.dk PI Email: bjeune@health.sdu.dk","+45 65503049","University of Southern Denmark
Epidemiology, Biostatistics and Biodemography,
Odense,
DK","Danish National Research Foundation
United States Department of Health and Human Services
National Institutes of Health
National Institute on Aging (NIA)",1998-2005,0,92-100,,"Parkinson's disease",,"No diagnosis",Denmark,,"0 to 4,999","60 to 100","Cognitive function|Mental health|Neurological","Individual physiological|Individual psychological","Height|Waist circumference|Weight","Cardiovascular|Hearing and Vision|Musculoskeletal|Reproductive|Respiratory",Blood|Other,"Gene screening",,,"Alcohol|Physical activity|Smoking","Education|Family circumstances|Housing and accommodation|Informal support|Marital status|Occupation and employment|Unpaid care","Formal health and social care service utilisation including private care","University of Southern Denmark",
"German Ageing Survey","The DEAS is a nationwide representative survey of the German population aged 40 and older that combines cross-sectional and longitudinal samples. Participants from baseline samples (drawn every six years) are followed up and enter the different panel samples. Panel data was collected at the same time as baseline samples until 2008. Starting from 2011, panel samples are interviewed every three years. Thus, DEAS enables an analysis of social change using the cross-sectional data of 1996, 2002, 2008, and 2014, as well as an investigation of intra-individual development over three to eighteen years (1996-2002-2008-2011-2014).
Last update - 16/02/2017",DEAS,"DEAS is a longitudinal study looking at ageing in the German population. 20,715 participants aged 40 to 85 were included at baseline however recruitment in ongoing.","1996 - present",,"Prof. Dr. Clemens Tesch-Roemer, Dr. Julia Simonson, Dr. Claudia Vogel","https://www.dza.de/en/research/deas.html","claudia.vogel@dza.de","+49 30 260740 23","Deutsches Zentrum für Altersfragen
Manfred-von-Richthofen-Straße 2,
12101 Berlin,
Deutschland","Federal Ministry for Family Affairs, Senior Citizens, Women and Youth (BMFSFJ)",1996-present,,40-85,,,,"No diagnosis",Germany,,"20,000 to 49,999","40 to 59|60 to 100","Cognitive function|Mental health","Individual physiological|Individual psychological",Height|Weight,"Hearing and Vision",,,,,"Alcohol|Physical activity|Smoking","Education|Family circumstances|Housing and accommodation|Income and finances|Informal support|Marital status|Occupation and employment|Unpaid care","Formal health and social care service utilisation including private care","German Centre of Gerontology",
"Dunedin Multidisciplinary Health and Development Study","The Dunedin Multidisciplinary Health and Development Study (DMHDS) is an ongoing, longitudinal study of the health, development and well-being of a general sample of New Zealanders. They were studied at birth (1972-73), followed up and assessed at the age of three when the longitudinal study was established. Since then they have been assessed every two years until the age of 15, then at ages 18 (1990-91), 21 (1993-94), 26 (1998-99), 32 (2003-2005), and 38 (2010-2012). It is planned to next see the Study members at age 44/45 and beyond.
Last update - 31/01/2017",DMHDS,"DMHDS is a longitudinal study of health, development and well-being of New Zealanders. 1,037 participants were recruited at birth to the study between 1972 and 1973.",1972-73,,"Dr Terrie Moffitt and Dr Richie Poulton","http://dunedinstudy.otago.ac.nz/","Email : dmhdru@otago.ac.nz, PI email: terrie.moffitt@duke.edu and PI email: richie.poulton@otago.ac.nz","+64 3 4798508","Dunedin Multidisciplinary Health and Development Research Unit,
Department of Psychology,
University of Otago,
PO Box 913,
Dunedin 9054,
New Zealand","UK Medical Research Council
US National Institute of Health
National Institute on Ageing",1972-73,,0,,"Mild cognitive impairment (MCI)|Subjective memory complaints (SMC) or subjective cognitive decline (SCD)",,"No diagnosis","New Zealand",,"0 to 4,999","0 to 9|10 to 19|20 to 39|40 to 59","Behaviour|Cognitive function|Mental health","Individual physiological|Individual psychological","Blood pressure|Height|Hip circumference|Waist circumference|Weight","Cardiovascular|Hearing and Vision|Musculoskeletal|Reproductive|Respiratory",Blood,"Gene screening","Magnetic resonance imaging (MRI)",,"Alcohol|Dietary habits|Physical activity|Smoking","Education|Ethnic group|Family circumstances|Housing and accommodation|Income and finances|Informal support|Marital status|Occupation and employment","Formal health and social care service utilisation including private care","Dunedin Multidisciplinary Health and Development Research Unit",
"Genetic Frontotemporal Dementia Initiative","GENFI is a five year longitudinal biomarker cohort study of genetic Frontotemporal Dementia and its associated disorders (including MND/ALS) investigating members of families with a known mutation in GRN or MAPT or an expansion in C9orf72 (including those affected with the disorder as well as at-risk members of families). Non-carrier first-degree relatives will serve as a control group.
All GENFI participants will be assessed longitudinally (annually) with a set of clinical, neuropsychiatric, cognitive, imaging and biosample protocols.
Last update - 25/01/2017",GENFI,"GENFI is a longitudinal cohort focused on Frontotemporal Dementia and its associated risks. 800 participants over 18 will be recruited between 2015-2020 to participate.",2015-20,"0 to 4,999","Dr Jonathan Rohrer","http://genfi.org.uk/","j.rohrer@ucl.ac.uk","+44 (0) 203 4483039","Dementia Research Centre,
UCL Institute of Neurology,
8-11 Queen Square,
London,
WC1N 3AR","UK Medical Research Council
The Bluefield Project",2015-20,500,>18,,"Frontotemporal dementia|Motor neurone disease",,"At-risk diagnosis","United Kingdom",,"0 to 4,999","10 to 19|20 to 39|40 to 59|60 to 100","Behaviour|Cognitive function|Neurological",,,,"Blood|Cerebral spinal fluid (CSF)","Gene screening","Magnetic resonance imaging (MRI)",,Alcohol|Smoking,"Education|Ethnic group|Occupation and employment",,"University College, London",
"Helsinki Birth Cohort Study","Helsinki Birth Cohort Study (HBCS) 1934-44 is a unique birth study including 13,345 subjects in the epidemiological cohort. The cohort is a longitudinal study cohort with data throughout the life span including prenatal life, early childhood and later life. Besides extensive epidemiological data over 2000 subjects have been randomly selected for a clinical part. The subjects have been followed up clinically for over one decade with extensive phenotypic data available including metabolic data, dietary information as well as other lifestyle data. Psychological factors including personality, depression and anxiety has been focused upon.
Last update - 07/02/2017",HBCS,"HBCS is an epidemiological cohort including 13,345 participants from birth and recruited between 1934-1944. Subjects were followed up clinically for over a decade. Psychological factors including personality, depression and anxiety has been focused upon.",1934,"0 to 4,999","Professor Johan Eriksson","http://research.med.helsinki.fi/obesity/Eriksson/","PI Email: johan.eriksson@helsinki.fi","+358 405016595","Institute of Clinical Medicine Department of General Practice and Primary Health Care,
407 P.O. Box 20,
Tukholmankatu 8 B 00014 University of Helsinki,
Finland","EU FP7, EU Horizon 2020
Academy of Finland
Samfundet Folkhälsan
Finnish foundations",1934,1080,0,,,,"No diagnosis",Finland,,"10,000 to 19,999","0 to 9|10 to 19|20 to 39|40 to 59|60 to 100","Mental health",,"Blood pressure|Height|Hip circumference|Waist circumference|Weight",Cardiovascular,Blood,,,,"Alcohol|Dietary habits|Physical activity|Smoking","Education|Family circumstances|Income and finances|Occupation and employment",,"Institute of Clinical Medicine Department of General Practice and Primary Health Care",
"Hellenic Longitudinal Investigation of Aging and Diet","The HELIAD is a population-based, multidisciplinary, collaborative study designed to estimate the prevalence and incidence of AD, other dementias, mild cognitive impairment, and other neuropsychiatric conditions of aging in the Greek population and to investigate associations between nutrition and cognitive dysfunction/age-related neuropsychiatric diseases in this Mediterranean population.
The participants in the HELIAD study were selected through random sampling from community-dwelling individuals over the age of 65 years in the cities of Larissa (located in the province of Thessaly in Central Greece and Marousi (located within the Athens Metropolitan area). The targeted sample of enrolled participants comprised approximately 2,500 individuals. No weighting or stratified sampling (according to age, gender, or education) was performed. Follow-ups with face-to-face interviews at ~3 year intervals.
Last update - 01/02/2017",HELIAD,"HELIAD is a population-based study designed to estimate the prevalence and incidence of neurodegenerative disease in the Greek population. Around 2,500 participants over 65 were recruited in 2011.",2011,"0 to 4,999","Nikolaos Scarmeas","https://cheba.unsw.edu.au/content/hellenic-longitudinal-investigation-aging-and-diet","PI Email: ns257@columbia.edu Data Contact Lena Margioti: eleni_margioti@yahoo.gr",,"Eginition Hospital,
72 Vasilisis Sofias Avenue,
Athens,
Greece,
11528","Alzheimer's Association
Athens Association of Alzheimer's Disease and Related Disorders
ESPA-EU program Excellence Grant (ARISTEIA)",2011,2500,>65,,"Alzheimer's disease|Dementia (unclassified)|Mild cognitive impairment (MCI)|Parkinson's disease|Subjective memory complaints (SMC) or subjective cognitive decline (SCD)",,"No diagnosis",Greece,,"0 to 4,999","60 to 100","Behaviour|Cognitive function|Mental health|Neurological","Individual physiological","Blood pressure|Height|Waist circumference|Weight","Cardiovascular|Hearing and Vision|Reproductive",Blood,"Gene screening",,"Consent for brain donation","Alcohol|Dietary habits|Physical activity|Smoking","Education|Ethnic group|Family circumstances|Housing and accommodation|Income and finances|Informal support|Marital status|Occupation and employment","Formal health and social care service utilisation including private care","Eginition Hospital",
"Hunter Community Study","The HCS is a population-based cohort study established to assess factors important in the health, well-being, social functioning and economic consequences of ageing. The participants included community-dwelling men and women aged 55-85 years of age who reside in Newcastle, New South Wales (NSW), Australia. They were randomly selected from the NSW State electoral roll and contacted between December 2004 and December 2007.
The participants' study data was collected through self-report postal questionnaires which covered a wide range of variables but also linked with local and national health information databases and hospital records. These provided follow-up on use of prescription medication, health service utilization and hospitalizations, morbidity and mortality. There was also a baseline clinic visit which measured a wide variety of parameters including hearing, vision, smell, balance, cognition, and lung function. Medications and diagnoses have been collected not only at baseline but also at periodic intervals during follow-up.
Last update - 31/01/2017","Hunter CS","The HCS is a population-based cohort study established to assess factors important in the health, well-being, social functioning and economic consequences of ageing. The study began in 2004 when 3,253 participants aged 55-85 were recruited.",2004-07,"0 to 4,999","Dr John Attia, Dr Mark McEvoy, Dr Catherine DEste, Dr Rodney Scott and Dr Peter Schofield","https://academic.oup.com/ije/article/39/6/1452/735859/Cohort-Profile-The-Hunter-Community-Study","PI Email: John.Attia@newcastle.edu.au","+61 (0)2 4042 0500","University of Newcastle,
School of Medicine and Public Health,
Callaghan,
New South Wales,
AU","University of Newcastle",2004-07,1749,55-85,,"Dementia (unclassified)|Mild cognitive impairment (MCI)|Parkinson's disease|Subjective memory complaints (SMC) or subjective cognitive decline (SCD)",,"No diagnosis",Australia,,"0 to 4,999","40 to 59|60 to 100","Behaviour|Cognitive function|Mental health|Neurological","Individual physiological|Individual psychological","Blood pressure|Height|Hip circumference|Waist circumference|Weight","Cardiovascular|Hearing and Vision|Musculoskeletal|Respiratory",Blood,"Gene screening","Magnetic resonance imaging (MRI)",,"Alcohol|Dietary habits|Physical activity|Smoking","Education|Ethnic group|Family circumstances|Housing and accommodation|Income and finances|Informal support|Marital status|Occupation and employment","Formal health and social care service utilisation including private care","University of Newcastles School of Medicine and Public Health and the Hunter New England Area Health Service",
"Longitudinal Ageing Study in India","The main objective of the Longitudinal Ageing Study in India (LASI) is to provide comprehensive longitudinal evidence base on health, social and economic wellbeing of elderly population in India.
LASI main wave's covers 30 states and 6 union territories of India covering a panel sample size of 60,250 elderly persons aged 45 years and above. The long-term goal of LASI is to continue this survey for the next 25 years with the first wave planned in the year 2016-17 and second wave in 2018-19. LASI aims to obtain all the indicators for each of the 30 states and 6 union territories. In addition, LASI aims at obtaining indicators for each of the four metropolitan cities of Delhi, Kolkata, Mumbai and Chennai.
Last update - 10/02/2017",LASI,"The main objective of LASI is to provide comprehensive longitudinal evidence base on health, social and economic wellbeing of elderly population in India. 60,250 participants will be recruited between 2016-2017 from Delhi, Kolkata, Mumbai and Chennai.",2016-2017,,"Professor Jinkook Lee, Professor David Bloom and Professor Perianayagam Arokiasamy","http://iipsindia.org/research_lasi.htm","PI Email: jinkookl@usc.edu",,"University of Southern California (USC),
Los Angeles,
CA 90007,
USA","Ministry of Health and Family Welfare (MoHFW) Govt. of India
National Institute on Aging (NIA)/ National Institutes of Health (NIH), USA
The United Nations Population Fund (UNFPA), India",2016-2017,,>45,,"Alzheimer's disease|Parkinson's disease",,"No diagnosis",India,,"50,000 to 99,999","40 to 59","Cognitive function|Mental health|Neurological","Caregiver|Individual physiological|Individual psychological","Blood pressure|Height|Hip circumference|Waist circumference|Weight","Cardiovascular|Hearing and Vision|Musculoskeletal|Respiratory",Blood,"Gene screening","Magnetic resonance imaging (MRI)",,"Alcohol|Dietary habits|Physical activity|Smoking","Education|Ethnic group|Family circumstances|Housing and accommodation|Income and finances|Informal support|Marital status|Occupation and employment|Unpaid care","Formal health and social care service utilisation including private care","Harvard T. H. Chan School of Public Health (HSPH)|International Institute of Population of Sciences (IIPS)|University of Southern California (USC)",
"Midlife in the U.S","The first wave of the MIDUS study collected survey data from a total of 7,108 participants. The baseline sample was comprised of individuals from four subsamples:

a national RDD (random digit dialing) sample (n=3,487);

oversamples from five metropolitan areas in the U.S. (n=757)

siblings of individuals from the RDD sample (n=950); and (4) a national RDD sample of twin pairs (n=1,914).

All eligible participants were non-institutionalized, English-speaking adults in the coterminous United States, aged 25 to 74. Data from the above samples were collected primarily in 1995/96.
Last update - 03/02/2017",MIDUS,"MIDUS is a population cohort with the aim of investigating the role of behavioural, psychological, and social factors in age-related variations in health and well-being. The study recruited 7,108 participants, 25 to 74 years old between 1995 and 1996.",1995-6,,"Dr Carol Ryff","http://midus.wisc.edu/scopeofstudy.php","bradler@wisc.edu","608 262 1818","Dr. Barry Radler, University of Wisconsin - Madison Institute on Aging, 1300 University Avenue, 2245 MSC, Madison, Wisconsin,53706-1532","National Institute on Aging (NIA)",1995-6,,25-74,,,,"No diagnosis",USA,,"5,000 to 9,999","20 to 39|40 to 59|60 to 100","Behaviour|Mental health|Neurological","Individual psychological","Blood pressure|Height|Hip circumference|Waist circumference|Weight",Cardiovascular|Musculoskeletal|Reproductive|Respiratory,Blood|Saliva|Urine,,"Electroencephalogram (EEG)|Magnetic resonance imaging (MRI)",,"Physical activity|Smoking","Education|Ethnic group|Family circumstances|Housing and accommodation|Income and finances|Informal support|Marital status|Occupation and employment|Unpaid care","Formal health and social care service utilisation including private care","UW-Madison Institute on Aging",
"Neuroimaging of Inflammation in Memory and Other Disorders","The NIMROD (Neuroimaging of Inflammation in Memory and Other Disorders) study aims to understand the role of inflammation in several forms of dementia, memory loss and depression (Alzheimer's disease (AD), dementia with Lewy bodies (DLB), Parkinsons disease dementia (PDD), progressive supranuclear palsy (PSP), frontotemporal dementia (FTD), late life depression (LLD), mild cognitive impairment (MCI)). It also aims to understand the changes in the immune system, from immune cells and other components in the blood and cerebrospinal fluid.
To achieve this, NIMROD looks at brain changes in dementia, depression and related disorders in several different ways, detecting differences in brain structure and function, measuring inflammation and annual psychology and memory assessments. A further aim is to investigate if neuroinflammation can predict subsequent clinical course, including cognitive and functional decline.
Last update - 01/02/2017",NIMROD,"NIMROD plans to recruit 145 participants between 2013 and 2017 over 50 years old. Its aim is to understand the role of inflammation in specific Neurodegenerative Diseases.",2013-17,"0 to 4,999","Professor John O'Brien","http://www.neurology.cam.ac.uk/neurology-unit-research-groups/syren/nimrod-2/","Email: robert.arnold@medschl.cam.ac.uk","+44 (0)1223 768003","Robert Arnold,
Department of Psychiatry,
University of Cambridge,
Herchel Smith Building,
Robinson Way,
Cambridge,
CB2 0SZ","NIHR Biomedical Research Unit in Dementia (BRU)",2013-17,145,>50,,"Alzheimer's disease|Dementia (unclassified)|Frontotemporal dementia|Lewy body disease|Mild cognitive impairment (MCI)|Other NDs not listed|Parkinson's disease",,"Condition diagnosed","United Kingdom",,"0 to 4,999","40 to 59|60 to 100","Cognitive function|Mental health|Neurological","Caregiver|Individual physiological|Individual psychological",,Cardiovascular,"Blood|Cerebral spinal fluid (CSF)|CSF biomarker data available",,"Magnetic resonance imaging (MRI)|Positron emission tomography (PET) - amyloid","Consent for brain donation","Alcohol|Physical activity|Smoking","Education|Housing and accommodation|Occupation and employment",,"University of Cambridge",
"The Three-City Study","The Three-City Study (3C Study) is a population-based longitudinal study of the relation between vascular diseases and dementia in persons aged 65 years and older. A total of 9,294 participants (3,649 men and 5,645 women) were recruited from three French cities: Bordeaux (2,104), Dijon (4,931) and Montpellier (2,259).
The principal objective is to estimate the risk of dementia (Alzheimer's disease and other types) that may be attributed to vascular factors.
In follow up 1 and 2 (2001-2004) participants were interviewed and subjected to physical and cognitive testing. In follow up 3 (2005-2012) participants completed a postal questionnaire. The third, fourth, and fith waves of follow-up examinations started in 2006 and finished in 2012. A sixth follow-up is ongoing.
Last update - 03/02/2017","3C study","The Three-City Study (3C Study) is a population-based longitudinal study looking at the relationship between vascular diseases and dementia. In1999 9,294 participants aged 65 years and older were recruited from Bordeaux, Dijon and Montepellier.",1999-2000,,"Christophe Tzourio|Jean-François Dartigues","http://www.three-city-study.com/","E3C.U708@inserm.fr",,"Christophe Tzourio, MD, PhD
Bordeaux Population Health Research Center (BPH),
Inserm U1219,
University of Bordeaux,
33076 Bordeaux France","Medical Research Foundation
Sanofi-Synthelabo company
Inserm",1999-2000,,>65,,"Alzheimer's disease|Dementia (unclassified)|Mild cognitive impairment (MCI)|Subjective memory complaints (SMC) or subjective cognitive decline (SCD)|Vascular dementia",,"No diagnosis",France,,"5,000 to 9,999","60 to 100","Cognitive function|Mental health|Neurological","Individual psychological","Blood pressure|Height|Hip circumference|Waist circumference|Weight","Cardiovascular|Hearing and Vision|Respiratory",Blood,"Gene screening","Magnetic resonance imaging (MRI)",,"Alcohol|Dietary habits|Physical activity|Smoking","Education|Ethnic group|Family circumstances|Housing and accommodation|Income and finances|Marital status|Occupation and employment","Formal health and social care service utilisation including private care","University of Bordeaux",
"Brains for Dementia Research","There are over 800,000 people with dementia in the UK today, and this figure is set to double in the next 30 years. Dementia has a huge impact on a person's life and is one of society's most urgent health and social care challenges. Despite this, treatment for dementia is very limited and there is no cure.
Human tissue is vital for dementia research but is currently in short supply and is not covered in standard organ donation schemes. With the support of Alzheimer's Society and Alzheimer's Research UK, Brains for Dementia Research was set up in 2007 to establish a network of brain bank facilities across England and Wales.
It is now a 'gold standard' for brain tissue banking, linking six leading centres (based in London, Oxford, Newcastle, Bristol, Manchester and Cardiff) in a network of common standards, best practice and cooperation. This lays the foundation to enable the highest quality dementia research, which aims to find a cure for dementia. In each bank, people with mild cognitive impairment or a diagnosis of dementia, and healthy participants, are supported to donate their brain by specialist research nurses.
This initiative is unique from other brain banks, as the memory, thinking and behaviour of each prospective donor are monitored throughout their later life through regular assessments. This provides researchers with a complete medical history to accompany the donated brain tissue, allowing them to see how brain changes correlate with symptoms.
Last update - 09/05/2018",BDR,"BDR began in 2007 and is network of brain bank facilities across England and Wales. This initiative is unique, as the memory, thinking and behaviour of each donor is monitored throughout their later life.",Unlimited,"0 to 4,999","Professor Alan Thomas","http://brainsfordementiaresearch.co.uk/brain-donation/","BDR.Coordinatingcentre@ncl.ac.uk","+44 (0) 191 208 2109","Nicky Barnett
BDR Senior Manager
Brains for Dementia Research Coordinating Centre Office
Ground Floor, Edwardson Building
Newcastle University
Institute of Neuroscience
Campus for Ageing and Vitality
Newcastle-upon-Tyne
NE4 5PL
","Alzheimer's Society
Alzheimer's Research UK",Unlimited,3200,65,,"Alzheimer's disease|Dementia (unclassified)|Frontotemporal dementia|Mild cognitive impairment (MCI)|Vascular dementia",,"No diagnosis","United Kingdom",,"0 to 4,999","60 to 100","Behaviour|Cognitive function|Mental health|Neurological","Individual psychological","Blood pressure|Hip circumference|Waist circumference","Hearing and Vision","Blood|Cerebral spinal fluid (CSF)|Other",,,"Consent for brain donation","Alcohol|Dietary habits|Physical activity|Smoking","Occupation and employment","Formal health and social care service utilisation including private care","Brains for Dementia Research Coordinating Centre",
"Belgian Ageing Studies","The Belgian Ageing Studies project (BAS) was developed by researchers at the Free University of Brussels (Vrije Universiteit Brussel) and University College Ghent (Hogeschool Gent). Established in the early 2000s, the BAS team engages in the scientific study of the social aspects of ageing.
The aim of the research programme of the Belgian Ageing Studies is to:

Provide an instrument to measure the living conditions and quality of life of older people in Belgian municipalities.

Promote evidence-based policy at the local level by providing input and mobilizing knowledge for planning and inclusive policy programmes.

Last update - 28/02/2017",BAS,"BAS is a population study looking at the social aspects of ageing. The ongoing study began in 2006 recruiting 75319 participants over 60 years old.","2006 - present",,"Professor Liesbeth De Donder","http://www.belgianageingstudies.be/","ldedonde@vub.ac.be","+32 (0) 26292531","Faculty of Psychology and Educational Sciences
Department of Educational Sciences
Pleinlaan 2 - 1050
Brussel",,"2006 - present",,>60,,,,"No diagnosis",Belgian,,"5,000 to 9,999","60 to 100","Mental health",,,"Hearing and Vision",,,,,"Physical activity","Education|Ethnic group|Family circumstances|Housing and accommodation|Income and finances|Informal support|Marital status|Occupation and employment|Unpaid care","Formal health and social care service utilisation including private care","Free University of Brussels (Vrije Universiteit Brussel)|University College Ghent (Hogeschool Gent)",
"British Regional Heart Study","The British Regional Heart Study (BRHS) is a prospective study in middle-aged men drawn from general practices in 24 British towns, 7,735 men were recruited in 1978-1980. It was set up to determine the factors responsible for the considerable variation in coronary heart disease, hypertension and stroke in Great Britain. It also seeks to determine the causes of these conditions in order to provide a rational basis for recommendations towards their prevention.
Following the collection of baseline date in 1978-80 the cohort has been followed up through the participants, two-yearly GP Record Reviews, and the Office of Population and Census Surveys. Participants have been re-contacted through questionnaires or assessment in 1983-85, 1992, 1996, 1998-2000, 2003, 2005, 2007 and 2010-2012, 2014, 2015, 2016.
Last update - 21/02/2017",BRHS,"BRHS is a population study set up to determine the factors responsible for the considerable variation in coronary heart disease, hypertension and stroke in Great Britain. Since 1978 7,735 middle aged men have been recruited .",1978-80,"0 to 4,999","Professor Peter Whincup and Professor Goya Wannamethee","http://www.ucl.ac.uk/pcph/research-groups-themes/brhs-pub","l.lennon@ucl.ac.uk","+44 (0) 207 830 2335 U20","British Regional Heart Study (BRHS)
Department of Primary Care & Population Health
Institute of Epidemiology and Health Care
UCL Faculty of Population Health Sciences
UCL Medical School
Royal Free Campus
Rowland Hill Street,
London NW3 2PF UK","British Heart Foundation",1978-80,27172,40-59,,"Alzheimer's disease|Dementia (unclassified)|Subjective memory complaints (SMC) or subjective cognitive decline (SCD)|Vascular dementia",,"No diagnosis","United Kingdom",,"5,000 to 9,999","40 to 59|60 to 100","Cognitive function|Mental health|Neurological","Individual physiological|Individual psychological","Blood pressure|Height|Hip circumference|Waist circumference|Weight","Cardiovascular|Hearing and Vision|Musculoskeletal|Respiratory",Blood|Urine,,,,"Alcohol|Dietary habits|Physical activity|Smoking","Education|Ethnic group|Family circumstances|Housing and accommodation|Income and finances|Informal support|Marital status|Occupation and employment",,"University College, London",
"Ageing in Women and Men: A Longitudinal Study of Gender Differences in Health Behaviour and Health among Elderly","GENDER is a study of unlike-sex twin pairs born between 1906 and 1925 (Gold et al., 2002). A survey concerning health and health behavior was mailed in 1994 with responses from 1,210 twins from 605 pairs where both responded. Mean age at baseline questionnaire assessment was 74.43 (SD 4.28) and all are Caucasians. A baseline in-person evaluation of 498 twins from 249 pairs between 70 and 80 years of age was undertaken between 1995 and 1997, and included an interview and tests of cognitive and physical functioning. Two additional in-person waves followed at 4-year intervals. Finally, a second survey was mailed in 2007 to all living twins who participated in the first mailed survey.
Last update - 04/03/2017",GENDER,"GENDER is a twin study which began in 1994 concerning health behaviour. 1,210 unlike-sex twins were recruited aged between 69-88.",1994,,"Associate Professor Anna Dahl Aslan","https://academic.oup.com/psychsocgerontology/article/57/3/S168/581328","PI Email: anna.dahl-aslan@ju.se","+49 (0) 761-714118","Institute of Gerontology,
School of Health and Welfare,
Jönköping University,
Box 1026, 551 11 Jönköping,
Sweden","MacArthur Foundation Research Network on Successsful Aging
The Axel and Margaret Axson Johnson's Foundation, The Swedish Council for Social Research
The Swedish Foundation for Health Care Sciences and Allergy Research",1994,,69-88,,"Alzheimer's disease|Dementia (unclassified)|Frontotemporal dementia|Other NDs not listed|Parkinson's disease|Vascular dementia",,"No diagnosis",Sweden,,"0 to 4,999","60 to 100","Cognitive function|Mental health|Neurological","Individual physiological|Individual psychological","Blood pressure|Height|Hip circumference|Waist circumference|Weight","Cardiovascular|Hearing and Vision|Musculoskeletal|Reproductive|Respiratory",Blood,"Gene screening",,"Consent for brain donation","Alcohol|Dietary habits|Physical activity|Smoking","Education|Housing and accommodation|Income and finances|Informal support|Marital status|Occupation and employment|Unpaid care","Formal health and social care service utilisation including private care","Jönköping University and Karolinska Institutet",
"Personality & Total Health (PATH) Through Life","The PATH Through Life project is a 20 year longitudinal cohort study of 7,485 young (aged 20-24 at baseline), midlife (aged 40-44 at baseline) and older (aged 60-64 at baseline) adults randomly sampled from the electoral roll of the Australian Capital Territory and the nearby city of Queanbeyan.
The original aims of the project are outlined below.

To delineate the course of depression, anxiety, substance use and cognitive ability with increasing age across the adult life span.

To identify environmental risk, genetic risk and protective factors influencing individual differences in the course of these characteristics.

To investigate interrelationships over time between the three domains of: depression and anxiety, substance use, and cognitive ability and dementia.

Data collection has occurred at four intervals (4 waves), at approximately four year intervals with a good participant retention rate. The fifth wave of data collection is commencing in 2017.
Several design features of the PATH project contribute to its unique standing among population based longitudinal cohort studies.

Use of a narrow age cohort design with longitudinal follow ups as an optimal means of separating age and cohort effects.

Assessment of participants across the full adult lifespan, permitting investigation of developmentally significant, but under studied periods such as midlife

Recruitment and follow up of a young-old population, providing important pre-clinical data for studying the development of age related changes in memory and cognition.

Last update - 12/01/2017",PATH,"PATH is a longitudinal cohort of 7,485 participants of different ages (over 20) sampled from the electoral roll. To investigate the course of depression and anxiety, substance use, and cognitive ability with age including the identification of risk and protective factors.",1999,"0 to 4,999","Professor Kaarin Anstey","http://crahw.anu.edu.au/research/projects/personality-total-health-path-through-life","kaarin.anstey@anu.edu.au","+61 2 6125 8410","Centre for Research on Ageing, Health & Wellbeing
The Australian National University
Florey, Building 54, Mills Road, Acton
ACT 2601 Australia","National Health and Medical Research Council",1999,4737,>20,,"Alzheimer's disease|Dementia (unclassified)|Mild cognitive impairment (MCI)|Subjective memory complaints (SMC) or subjective cognitive decline (SCD)",,"No diagnosis",Australia,,"5,000 to 9,999","20 to 39|40 to 59|60 to 100","Behaviour|Cognitive function|Mental health|Neurological","Individual physiological|Individual psychological","Blood pressure|Height|Waist circumference|Weight","Cardiovascular|Hearing and Vision|Musculoskeletal|Reproductive|Respiratory",Blood|Other,"Gene screening","Magnetic resonance imaging (MRI)",,"Alcohol|Dietary habits|Physical activity|Smoking","Education|Ethnic group|Family circumstances|Housing and accommodation|Income and finances|Informal support|Marital status|Occupation and employment|Unpaid care","Formal health and social care service utilisation including private care","The Australian National University",
"Parkinsonism: Incidence and cognitive heterogeneity in Cambridgeshire","The PICNICS study is an observational study tracking the progression of patients with incident Parkinson's disease over several years to better understand how the disease behaves over time, and establish the pattern of evolution of subtypes of Parkinson's disease. Understanding differences between subtypes and what drives them will inform development of stratified therapies. The study recruited patients with Parkinson's disease between 2008 and 2013, and is following them up every 18 months with clinical assessments, cognitive assessments and biological sampling.
Last update - 16/01/2017","PICNICS Cohort","PICNICS is an observational cohort looking at the progression of Parkinson's disease over several years. Recruitment began in 2008 of 290 participants over 18 years old.",2008-13,"0 to 4,999","Professor Roger Barker","http://thebarkerlab.co.uk/parkinsons-disease/","dmj34@cam.ac.uk","+44 (0) 1223 331160","John van Geest Centre for Brain Repair,
University of Cambridge,
Forvie Site,
Robinson Way,
Cambridge,
CB2 0PY,
UK.","The Cure Parkinson's Trust
Van Geest Foundation; Parkinson's UK
National Institute of Health Research Biomedical Research Centre Award to the University of Cambridge",2008-13,150,>18,,"Mild cognitive impairment (MCI)|Parkinson's disease",,"Condition diagnosed","United Kingdom",,"0 to 4,999","10 to 19|20 to 39","Behaviour|Cognitive function|Mental health|Neurological","Caregiver|Individual physiological|Individual psychological",,,Blood,"Gene screening",,"Consent for brain donation",Smoking,"Education|Ethnic group|Marital status|Occupation and employment",,"University of Cambridge",
"PREVENT Research Programme","The PREVENT Research Programme has established a cohort of individuals to explore differences in the brain and cognitive function in healthy people in mid-life (aged 40-59). People are grouped into high, mid and low risk based on their family history and APOE status (a well-known risk gene for Alzheimer's disease).
650 participants are assessed on biological indicators including markers in blood, saliva, urine and spinal fluid as well as direct imaging of the brain's structure and function. Changes in all of these markers will be monitored at 2 years to work out if risks that predict these changes. One of the main aims of the study is to identify the earliest signs of changes in the brain whilst people are still in good health.
Last update -13/12/2017",PREVENT,"PREVENT is a longitudinal study aimed at exploring the differences in the brain and cognitive function in healthy people aged 40-59. Recruitment began in 2014, the estimated current sample size is 240.",2014-present,"0 to 4,999","Professor Craig Ritchie","http://preventdementia.co.uk/","katie.wells@imperial.ac.uk","+44 (0) 20 8483 1823","Katie Wells
PREVENT Research Programme
West London Cognitive Disorders Treatment and Research Unit
Imperial College London
Lakeside Mental Health Unit
West Middlesex Hospital site
Twickenham Road
Isleworth
TW7 6FY","Alzheimer's Society
Fidelity and Alzheimer's Association",2014-present,240,40-59,,"Alzheimer's disease|Dementia (unclassified)|Frontotemporal dementia|Subjective memory complaints (SMC) or subjective cognitive decline (SCD)|Vascular dementia",,"At-risk diagnosis","United Kingdom",,"0 to 4,999","40 to 59","Behaviour|Cognitive function|Mental health|Neurological","Individual physiological|Individual psychological","Blood pressure|Height|Hip circumference|Waist circumference|Weight","Cardiovascular|Hearing and Vision|Respiratory","Blood|Cerebral spinal fluid (CSF)|CSF biomarker data available|Saliva|Urine","Gene screening","Magnetic resonance imaging (MRI)|Magnetic resonance spectroscopy (MRS)",,"Alcohol|Dietary habits|Smoking","Education|Ethnic group|Housing and accommodation|Income and finances|Marital status|Occupation and employment",,"University of Edinburgh",
CoLaus¦PsyCoLaus,"The major goals of this prospective cohort study of a randomly selected community sample are to: establish the prevalence and genetic, metabolic and environmental determinants of psychiatric disorders, cardiovascular risk factors (CVRF) and cardiovascular diseases (CVD) in the general population of the city of Lausanne; assess the mechanisms of the association between psychiatric disorders and CVRF / CVD.
Additional scientific questions focus on:

the identification of risk factors for the incidence and course of CVRF and psychiatric disorders;
the identification of risk factors for cognitive impairment;

the testing of novel biological marker candidates and the incidence or course of CVRF/CVD or psychiatric disorders;

the testing of associations between brain anatomy patterns and CVRF and psychiatric disorders.

Last update: 19/12/2016",,"PsyCoLaus is a prospective cohort study to assess the health and well-being of the city of Lausanne. 6,734 participants aged 35-75 were recruited between 2003 and 2006.",2003-06,"5,000 to 9,999","Professor Martin Preisig (psychiatric part), Professor Gerard Waeber and Professor Peter Vollenweider (physical part)","http://www.colaus.ch/","etude.colaus@chuv.ch","+44 41213 147361","CoLaus¦PsyCoLaus
CHUV
Rue du Bugnon 19
CH-1011 Lausanne","GlaxoSmithKline (baseline investigation)
Swiss National Science Foundation (baseline and follow-up investigations)",2003-06,4500,35-75,,"Alzheimer's disease|Mild cognitive impairment (MCI)",,"No diagnosis",Switzerland,,"5,000 to 9,999","20 to 39|40 to 59|60 to 100","Behaviour|Cognitive function|Mental health|Neurological","Individual psychological","Blood pressure|Height|Hip circumference|Waist circumference|Weight",Cardiovascular|Respiratory,Blood|Urine,"Gene screening","Magnetic resonance imaging (MRI)",,"Alcohol|Dietary habits|Physical activity|Smoking","Education|Ethnic group|Family circumstances|Income and finances|Informal support|Marital status","Formal health and social care service utilisation including private care","University Hospital Of Lausanne (CHUV)",
"The Thai Cohort","The Thai Cohort Study was established in 2005 in order to study the dynamics, drivers and impacts of the population transition from high maternal and child mortality and infectious disease to low mortality and chronic disease. We call this the 'health-risk transition' - synchronised change in causal risks and health outcomes affecting whole populations, with Thailand being a good example in the SE Asia region. This transition can be divided into overlapping or interacting component transitions such as the nutrition transition, the health system transition, sexual transition, the transport transition, the (formal) work transition and the environment transition (including urbanisation). As our understanding improves we are better able to inform governments about changing health service demands and changing prevention needs -- with universal
health insurance and Thai obesity research being two prominent examples of national response.
Cohort members are distance-learning students who resided nationwide and were enrolled at the Sukhothai Thammathirat Open University when they responded to a 20-page baseline questionnaire in 2005 (n= 87,151). A four and eight year follow-up were conducted with a response rate of approximately 70% at each follow-up (n=60,569 in 2009 and n=42,785 in 2013). At 2005 baseline, median age was 29 years, roughly half the sample were females, and approximately half were urban residents.
For mortality data linkage, all cohort members have provided their Citizen ID number which was matched with death records from the Thai Ministry of Interior and subsequently linked with causes of death from the Ministry of Public Health. Up until November 2016, there were a total of 1,401 deaths among the Thai Cohort Study participants.
Last update: 22/01/2017",,"The Thai Cohort is a population study of 87,151 participants between 15 and 88 recruited in 2004-5. The aim of the cohort is to study the impacts or health risk transitions.",2004-5,,"Professor Adrian Sleigh and Associate Professor Sam-ang Seubsman","https://ije.oxfordjournals.org/content/37/2/266.full.pdf+html","PI email: adrian.sleigh@anu.edu.au PI email: sam-ang-seu@stou.ac.th",,"Sukhothai Thammathirat Open University
Chaengwattana Road
Bangpood
Pakkret Nonthaburi
11120
Thailand","International Collaborative Research Grants Scheme, Wellcome Trust UK and Australian NHMRC",2004-5,,>15,,,,"No diagnosis",Thailand,,"50,000 to 99,999","10 to 19|20 to 39|40 to 59|60 to 100","Mental health",,"Blood pressure|Height|Weight",,,,,,"Alcohol|Dietary habits|Physical activity|Smoking","Education|Ethnic group|Family circumstances|Housing and accommodation|Income and finances|Informal support|Marital status|Occupation and employment|Unpaid care","Formal health and social care service utilisation including private care","Thailand's Sukhothai Thammathirat Open University",
"Avon Longitudinal Study of Parents and Children","Based at the University of Bristol, the Avon Longitudinal Study of Parents and Children (ALSPAC), also known as Children of the 90s, is a world-leading birth cohort study. Between April 1991 and December 1992 more than 14,000 pregnant women were recruited into the study and these women (some of whom had two pregnancies or multiple births during the recruitment period), the children arising from the pregnancy, and their partners have been followed up over two decades.
The cohort has been followed intensively with annual questionnaires for the mothers, fathers and the children from age 5. A 10% sample of children were seen 10 times between 4 and 61 months for clinic assessment. Annual clinic assessment of the whole cohort was conducted from the age of 7 to 13 and 15 to 17. Assessment at age 24/25 is currently planned.
Record linkage has been completed for Education, Hospital Episode Statistics, Clinical Practice Research Datalink and Death notification and cancer cases.
1 million biological samples are held including maternal blood and urine, umbilical cord blood, placentas, paternal blood and saliva and childrens blood, saliva and urine.
The study has been extended to include grandparents, siblings, and children of the children and recruitment is underway.
ALSPAC is part of CLOSER (Cohort & Longitudinal Studies Enhancement Resources) which aims to maximise the use, value and impact of the UK's longitudinal studies.
Last update: 12/01/2017",ALSPAC,"ALSPAC is a birth cohort study aiming to chart the health of 14,500 families in Bristol to improve the health of future generations. Pregnant women aged 16 - 45 were recruited between April 1991 and December 1992.",1991-1992,"20,000 to 49,999","Professor George Davey-Smith and Professor Paul Burton","http://www.bris.ac.uk/alspac/","Data enquiries (including access): alspac-data@bristol.ac.uk, Media enquiries: media@childrenofthe90s.ac.uk, Lab enquiries: alspac-lab@bristol.ac.uk, Research-related enquiries: alspac-exec@bristol.ac.uk",,"Children of the 90s
Oakfield House
Oakfield Grove
Bristol
BS8 2BN","Medical Research Council
Wellcome Trust",1991-1992,22528,"Children 0 and Mothers 16-45",,,,"No diagnosis","United Kingdom",,"20,000 to 49,999","0 to 9|10 to 19|20 to 39|40 to 59|60 to 100","Cognitive function|Mental health","Individual psychological","Blood pressure|Height|Hip circumference|Waist circumference|Weight","Cardiovascular|Hearing and Vision|Musculoskeletal|Reproductive|Respiratory",Blood|Other|Saliva|Urine,,,,"Alcohol|Dietary habits|Physical activity|Smoking","Education|Ethnic group|Family circumstances|Housing and accommodation|Income and finances|Informal support|Marital status|Occupation and employment|Unpaid care","Formal health and social care service utilisation including private care","University of Bristol",
"Behaviour and Pain in Dementia","BePaiD (Behaviour and Pain in Dementia) is a longitudinal cohort study of 230 people with dementia, aged over 70, admitted to hospital for acute medical illness, and assessed for BPSD and pain at admission and every 4 (+1) days until discharge. Other measures included length of stay, care quality indicators, adverse events and mortality.
The aim of the study is to define the prevalence of behavioural and psychological symptoms of dementia (BPSD) and explore their clinical associations, particularly with pain, BPSD encompasses a range of symptoms including agitation, aggression, delusions, hallucinations, depression and apathy.
Last update: 16/01/2017",BePAID,"BePaiD is a longitudinal cohort study of 230 people with dementia, aged over 70, admitted to hospital for acute medical illness. The aim of the study is to define the prevalence of behavioural and psychological symptoms of dementia.",04.04.11-06.03.12,"0 to 4,999","Dr Elizabeth L Sampson","http://bjp.rcpsych.org/content/205/3/189","e.sampson@ucl.ac.uk",,"Marie Curie Palliative Care Research Department,
Division of Psychiatry,
University College,
London,
UK","Alzheimers Society
BUPA Foundation",04.04.11-06.03.12,230,>70,,"Dementia (unclassified)",,"Condition diagnosed","United Kingdom",,"0 to 4,999","60 to 100","Behaviour|Cognitive function","Individual psychological",,,,,,,,"Ethnic group|Housing and accommodation","Formal health and social care service utilisation including private care","University College, London",
"The Busselton Healthy Ageing Study","The Busselton Healthy Ageing Study aims to enhance understanding of ageing by relating the clustering and interactions of common chronic conditions in adults to function. Phase I (recruitment) is a cross-sectional community-based prospective cohort study involving 5,107 'Baby Boomers' (born from 1946 to 1964) living in the Busselton Shire, Western Australia. The study protocol involves a detailed, self-administered health and risk factor questionnaire and a range of physical assessments including body composition and bone density measurements, cardiovascular profiling (blood pressure, ECG and brachial pulse wave velocity), retinal photography, tonometry, auto-refraction, spirometry and bronchodilator responsiveness, skin allergy prick tests, sleep apnoea screening, tympanometry and audiometry, grip strength, mobility, balance and leg extensor strength. Cognitive function and reserve, semantic memory, and pre-morbid intelligence are assessed. Phase 2 (longitudinal, 6 year follow-up) commenced in 2016.
Last update: 25/01/2017",BHAS,"BHAS is an ageing study which aims to enhance understanding of ageing by relating the clustering and interactions of common chronic conditions in adults to function. This cross sectional prospective cohort involves 5,107 participants living on Busselton shire in 2010.","Phase 1: 2010-15 and Phase 2: 2016-21","5,000 to 9,999","Professor Alan James","http://bpmri.org.au/research/key-projects-studies/busselton-health-study-2.html#item-2","admin@bpmri.org.au","+61 (08) 9754 0548","Busselton Population Medical Research Institute (Inc.)
PO Box 659,
BUSSELTON
WA 6280","The Busselton Population Medical Research Institute
Office of Science and Department of Health of the Government of Western Australia","Phase 1: 2010-15 and Phase 2: 2016-21",5050,46-69,,"Alzheimer's disease|Mild cognitive impairment (MCI)|Parkinson's disease|Subjective memory complaints (SMC) or subjective cognitive decline (SCD)|Vascular dementia",,"No diagnosis",Australia,,"5,000 to 9,999","40 to 59|60 to 100","Cognitive function|Mental health|Neurological","Individual psychological","Blood pressure|Height|Hip circumference|Waist circumference|Weight","Cardiovascular|Hearing and Vision|Musculoskeletal|Reproductive|Respiratory",Blood|Microbiome,"Gene screening",,,"Alcohol|Dietary habits|Physical activity|Smoking","Education|Ethnic group|Housing and accommodation|Income and finances|Marital status|Occupation and employment","Formal health and social care service utilisation including private care","Busselton Population Medical Research Institute",
"Boyd Orr Cohort Study","The Boyd Orr cohort is an historical cohort study carried out by the University of Bristol School of Social Medicine to investigate the long term impact of childrens diet, growth, living conditions and health on adult cardiovascular disease. It is based upon based on the 65 year follow-up of the Carnegie Survey of Diet and Health (1937-9).
It is based on the long term follow-up of 4,999 children who were surveyed in the Carnegie United Kingdom Trust's study of Family Diet and Health in Pre-War Britain (1937-1939). With funding from the British Heart Foundation, the cohort was established in 1988 by Professors George Davey Smith and Stephen Frankel who retrieved the original research records of the pre-war survey from the Rowett Research Institute.
Last update: 11/01/2017",BO,"The Boyd Orr cohort is a longitudinal cohort looking to investigate the long term impact of health and social factors during childhood on cardiovascular disease. 4,999 participants were followed up in 1988 originally recruited between 1937-1939.",1937-39,"0 to 4,999","Professor Richard Martin","http://www.bris.ac.uk/social-community-medicine/projects/boyd-orr/",,,"Boyd Orr Cohort Study
School of Social and Community Medicine
University of Bristol
Canynge Hall
39 Whatley Road
Bristol, BS8 2PS
United Kingdom","Medical Research Council (UK)|The World Cancer Research Fund
Research into Ageing
UK Survivors
The Economic and Social Research Council
The Wellcome Trust and the British Heart Foundation",1937-39,3762,0-19,,,,"No diagnosis","United Kingdom",,"0 to 4,999","0 to 9|10 to 19|20 to 39|40 to 59|60 to 100",,,"Blood pressure|Height|Hip circumference|Waist circumference|Weight",Cardiovascular|Reproductive|Respiratory,Blood,,,,"Alcohol|Dietary habits|Physical activity|Smoking","Education|Family circumstances|Housing and accommodation|Income and finances|Marital status|Occupation and employment",,"University of Bristol",
"The Cambridge City over-75s Cohort Study","The Cambridge City over-75s Cohort Study (CC75C) is a long-term follow-up study of a representative population-based sample of older people which started in 1985 from a survey of over 2,600 men and women aged 75 and above. Through a series of interviews and assessments spanning almost three decades they have contributed to one of the largest and longest-running longitudinal observational studies of ageing into older old age.
The initial study targeted all men and women aged 75 or older who were registered within a selection of geographically and socially representative general practices in Cambridge, and achieved a 95% response rate in six of the seven practices. From this original survey of 2610 people, 2166 individuals form the baseline sample for the longitudinal cohort. This group has been followed up through ten surveys, with sub-groups assessed more often. Similarly high response rates amongst participants still alive in their late 80s or 90s, and even amongst centenarians, have built an extensive resource of quantitative and qualitative data contributed by a representative sample of very old people and their relatives.
The focus in later years shifted to quality of life issues of 'older old' people near the end of life for which we have been interviewing relatives or carers of surviving members of the cohort all aged 95 or more, as well as these study participants themselves.
Last update: 05/01//2017",CC75C,"CC75 is a population study; its initial aim in 1985 was to look at ageing but has moved towards a study of people near the end of life (2016). 2,600 participants over 75 were recruitment.",1985-87,"0 to 4,999","Professor Carol Brayne","http://www.cc75c.group.cam.ac.uk","PI Email: carol.brayne@medschl.cam.ac.uk Study Co-ordinator Email: jane.fleming@medschl.cam.ac.uk Computer Officer (Emily Zhao) Email: ez219@medschl.cam.ac.uk","+44 (0) 1223 330334","Department of Public Health and Primary Care, Cambridge Institute of Public Health, Forvie Site|University of Cambridge School of Clinical Medicine, Box 113 Cambridge Biomedical Campus, Cambridge CB2 0SR, UK","Most recent funders: BMA Foundation for Medical Research, Abbeyfield Research Foundation, National Institute for Health Research CLAHRC and The BUPA Foundation;
For full list of funders over three decades see: http://www.cc75c.group.cam.ac.uk/background/grants/",1985-87,0,≥75,,"Alzheimer's disease|Dementia (unclassified)|Parkinson's disease|Vascular dementia",,"No diagnosis","United Kingdom",,"0 to 4,999","60 to 100","Behaviour|Cognitive function|Mental health|Neurological","Individual psychological",,"Hearing and Vision|Musculoskeletal","Blood|Cerebral spinal fluid (CSF)|Other|Saliva","Gene screening",,"Consent for brain donation","Alcohol|Physical activity|Smoking","Education|Family circumstances|Housing and accommodation|Informal support|Marital status|Occupation and employment|Unpaid care","Formal health and social care service utilisation including private care","Cambridge Institute of Public Health",
"MRC Cognitive Function and Ageing Studies","MRC CFAS study started in the late 1980s with the initial aim of investigating dementia and cognitive decline in a representative sample of more than 18,000 people aged over 65 years. To date there have been in the region of 48,000 interviews with participants in the study. The range of information collected has also allowed the study to investigate depression and physical disability in the older population and also look at healthy active life expectancy. Following baseline interviews, subsets of the cohort have been contacted for 1, 2, 6 and 8 year follow up and the whole sample were contacted for a 10 year follow up. There have also been in excess of 580 donations of participants brains after death.
CFAS is part of the Dementias Platform UK (DPUK), a multi-million pound public-private partnership to accelerate progress in dementias research http://www.mrc.ac.uk/research/facilities/dementias-platform-uk/
There is a sister study CFAS II which builds on the design and infrastructure of MRC CFAS. It has provided data on generational and geographical differences including people in institutions. CFAS I is the original three sites (Cambridge, Newcastle and Nottingham) from MRC CFAS which are used as a comparitor for CFAS II.
Last update: 13/01/2017","MRC CFAS 1","CFAS Is initial aim was to investigate dementia and cognitive decline in a representative sample of more than 18,000 people aged 65 years or over. This population cohort began in the late 1980s.",1989-92,"0 to 4,999","Professor Carol Brayne","http://www.cfas.ac.uk/","leb22@medschl.cam.ac.uk","+44 (0) 1223 330312","CFAS
Institute of Public Health
Forvie Site
University of Cambridge School of Clinical Medicine
Cambridge Biomedical Campus
Cambridge
CB2 0SR","Alzheimer's Society
Previously MRC",1989-92,150,>65,,"Dementia (unclassified)|Mild cognitive impairment (MCI)|Parkinson's disease|Subjective memory complaints (SMC) or subjective cognitive decline (SCD)",,"No diagnosis","United Kingdom",,"10,000 to 19,999","60 to 100","Behaviour|Cognitive function|Mental health|Neurological","Individual physiological|Individual psychological",,"Cardiovascular|Hearing and Vision|Respiratory",Blood|Other|Saliva,,,"Consent for brain donation","Alcohol|Dietary habits|Physical activity|Smoking","Education|Ethnic group|Family circumstances|Housing and accommodation|Marital status|Occupation and employment|Unpaid care","Formal health and social care service utilisation including private care","University of Cambridge, School of Clinical Medicine",
"Cognitive Function and Ageing Studies II","CFAS II based in England and Wales started in 2008, and builds on the design and infrastructure of original CFAS. It has provided data on generational and geographical differences including people in institutions. It will also provide important base-line information on older people aged 65-84 in 2007-2008 who will reach the age of greatest frailty during the 2020s when the peak in the number of people aged 85 or over is expected and at a time when major therapeutic interventions for dementia could be expected to have an effect. Participants were followed up by interview throughout 2010-2011.
CFAS II is part of the Dementias Platform UK (DPUK), a multi-million pound public-private partnership to accelerate progress in dementias research http://www.mrc.ac.uk/research/facilities/dementias-platform-uk/
Last update: 13/01/2017","CFAS II","Builds on CFAS I design, this population cohort aims to provide information on generational and geographical differences of 7,524 individuals who were 65-84 years old in 2007-8 who will reach greatest frailty during 2020s.",2008,"5,000 to 9,999","Professor Carol Brayne","http://www.cfas.ac.uk/","leb22@medschl.cam.ac.uk","+44 (0) 1223 330312","CFAS
Institute of Public Health
Forvie Site
University of Cambridge School of Clinical Medicine
Cambridge Biomedical Campus
Cambridge
CB2 0SR","Alzheimer's Society",2008,7524,>65,,"Dementia (unclassified)|Mild cognitive impairment (MCI)|Parkinson's disease|Subjective memory complaints (SMC) or subjective cognitive decline (SCD)",,"No diagnosis","United Kingdom",,"5,000 to 9,999","60 to 100","Behaviour|Cognitive function|Mental health|Neurological","Individual physiological|Individual psychological",,"Cardiovascular|Hearing and Vision|Respiratory",Other|Saliva,,,"Consent for brain donation","Alcohol|Dietary habits|Physical activity|Smoking","Education|Ethnic group|Family circumstances|Housing and accommodation|Marital status|Occupation and employment|Unpaid care","Formal health and social care service utilisation including private care","University of Cambridge, School of Clinical Medicine",
"English Longitudinal Study of Ageing","The primary objective of the English Longitudinal Study of Ageing (ELSA) is to collect longitudinal multidisciplinary data from a representative sample of the English population aged 50 and older. It began in 2002 and recruited over 12,000 people.
The study collects both objective and subjective data relating to health and disability, biological markers of disease, economic circumstance, social participation, networks and well-being. ELSA aims to measure outcomes across a wide range of domains and to provide high-quality multidisciplinary data that can shed light on the causes and consequences of outcomes of interest.
There have been seven sweeps of data collection 2002-03, 2004-05, 2006-07, 2008-09, 2010-11, 2012-2013, 2014-2015 and an eighth sweep (2016-2017) is currently underway.
The survey data are designed to be used for the investigation of a broad set of topics relevant to understanding the ageing process. These include:

the nature and timing of retirement and post-retirement labour market activity;

household and family structure, social networks and social supports;

patterns, determinants and consequences of social, civic and cultural participation;

predictors of well-being.

ELSA is part of the Dementias Platform UK (DPUK), a multi-million pound public-private partnership to accelerate progress in dementias research.
Last update: 13/01/2017",ELSA,"ELSA is a Longitudinal cohort study which recruited 12,000 participants over 50 in 2002. Its aim is to provide high quality multidisciplinary data that can shed light on the causes and consequences of outcomes of interest.",2002-03,"10,000 to 19,999","Professor Andrew Steptoe","http://www.ifs.org.uk/ELSA","n.rogers@ucl.ac.uk","+44 (0)20 7679 1656","Nina Rogers
ELSA Project Manager
Dept. of Epidemiology & Public Health
University College London
1-19 Torrington Place
London
WC1E 6BT","UK Government Consortium (Department for Communities and Local Government, Department for Transport, Department for Work and Pensions, HM Revenue and Customs, Office for National Statistics, Department of Health, Office for National Statistics)
ESRC
National Institute on Aging (NIH)",2002-03,10317,>50,,"Alzheimer's disease|Parkinson's disease",,"No diagnosis","United Kingdom",,"10,000 to 19,999","40 to 59|60 to 100","Cognitive function|Mental health|Neurological","Individual physiological|Individual psychological","Blood pressure|Height|Waist circumference|Weight","Cardiovascular|Hearing and Vision|Musculoskeletal|Reproductive|Respiratory",Blood|Other|Saliva,,,,"Alcohol|Dietary habits|Physical activity|Smoking","Education|Ethnic group|Marital status|Occupation and employment",,"University College, London",
"European Prospective Investigation of Cancer Norfolk","The Norfolk component of the European Prospective Investigation of Cancer (EPIC) recruited over 30,000 people from 1993 to 2000. EPIC-Norfolk participants are men and women who were aged between 40 and 79 when they joined the study and who lived in Norwich and the surrounding towns and rural areas. They have been contributing information about their diet, lifestyle and health through questionnaires and health checks over two decades.
Following baseline data collection the cohort has been followed up at 18 months by questionnaire, 3 years (1997-2000) - second health check and questionnaire, 10 years - health questionnaire , 13 years (2006-2011) - third Health examination and questionnaire.
The primary aim of the ten country half a million international EPIC collaboration is to examine the relationships between diet and incident cancers; that is, cancers which have developed after they joined the study. This broadened to include lifestyle and genetic factors and other diseases
A secondary aim is to study the relationship between dietary intake and other diseases and disease risk factors. In EPIC-Norfolk, these include heart attacks and strokes, rheumatoid arthritis, diabetes, thyroid disease, osteoporosis, dementia, eye diseases and many others. We are also studying the link between disease and other factors, such as psychosocial health.
EPIC Norfolk is part of the Dementias Platform UK (DPUK), a multi-million pound public-private partnership to accelerate progress in dementias research.
Last update: 07/12/2017","EPIC - Norfolk","EPICNorfolk is a component of a ten country collaboration which began in 1993 looking at the relationship between diet and cancer and diet and other diseases. EPIC-Norfolk recruited over 30,000 participants aged between 40-79.",1993-97,"20,000 to 49,999","Professor Kay-Tee Khaw","http://www.srl.cam.ac.uk/epic/","PI Email: Kk101@medschl.cam.ac.uk. General Email: epic@srl.cam.ac.uk ","+44 (0) 1223 740170","Strangeways Research Laboratory
Wort's Causeway
Cambridge
CB1 8RN","Medical Research Council
Cancer Research UK",1993-97,20025,40-79,,,,"No diagnosis","United Kingdom",,"20,000 to 49,999","40 to 59|60 to 100","Cognitive function",,"Blood pressure|Height|Hip circumference|Waist circumference|Weight","Cardiovascular|Hearing and Vision|Musculoskeletal|Reproductive|Respiratory","Blood|Cerebral spinal fluid (CSF)|CSF biomarker data available|Other|Urine",,,,"Alcohol|Dietary habits|Physical activity|Smoking","Education|Ethnic group|Family circumstances|Housing and accommodation|Income and finances|Informal support|Marital status|Occupation and employment","Formal health and social care service utilisation including private care","University of Cambridge",
"The Gipuzkoa Alzheimer Project Study","The Gipuzkoa Alzheimer Project (PGA) is a longitudinal study on pre-clinical Alzheimer's disease. This study aims to investigate the prevalence, clinical, cognitive and neuroimaging features and potential risk factors related to cardiovascular health and lifestyles for pre-clinical AD in asymptomatic (or very mildly symtopmatic, e.g. SCD) subjects from the community.
Follow-up Scheduled every 3 years for a minimum of 12 years. The first 3-year follow-up was completed in June 2015. The loss of subjects in the follow up was 9 %. 80% of people who donated cerebrospinal fluid at the baseline visit did the same in this follow-up visit. Second follow-up visit (6 yrs) to be started in April 2017.
Last update: 16/01/2017",GAP,"GAP/PGA is a longitudinal study on pre-clinical Alzheimer's disease. 396 participants aged between 40-80yrs were recruited between May 2011 and December 2012.","May 11-Dec 12","0 to 4,999","Dr. Pablo Martinez-Lage","http://www.cita-alzheimer.org/projects/gipuzkoa-alzheimer-project-basque-cohort","PI Email: pmlage@cita-alzheimer.org","+34 (0) 943021792","Fundación CITA-Alzheimer Fundazioa
Pº Mikeletegi 71
20009 Donostia-San Sebastián
España","Fundacion Cita-Alzheimer Fundazioa
Basque Government
Gipuzkoa Local Government
Kutxa Fundazioa","May 11-Dec 12",230,40-80,,"Alzheimer's disease|Frontotemporal dementia|Mild cognitive impairment (MCI)|Subjective memory complaints (SMC) or subjective cognitive decline (SCD)|Vascular dementia",,"At-risk diagnosis",Spain,,"0 to 4,999","40 to 59|60 to 100","Mental health","Individual physiological|Individual psychological","Blood pressure|Height|Hip circumference|Waist circumference|Weight",Cardiovascular,Blood|Urine,,"Magnetic resonance imaging (MRI)|Magnetic resonance spectroscopy (MRS)",,"Alcohol|Dietary habits|Physical activity|Smoking",,,"Fundación CITA-Alzheimer Fundazioa",
"Hertfordshire Birth Cohort","The Hertfordshire Cohort Study comprises a nationally unique study of 3000 men and women born during the period 1931-1939 and still resident in the English county of Hertfordshire. Information available on these individuals includes birthweight (recorded by the attending midwife), weight at age one year (recorded by a health visitor), the method of infant feeding, and details of childhood illnesses up to age five years. Follow-up of individuals began in 1990 and medical and social histories have been ascertained, as well as detailed anthropometry, blood pressure, glucose tolerance, fasting serum cholesterol and triglycerides, bone density and physical performance. DNA on all participants has been collected and is stored in the MRC Lifecourse Epidemiology Unit, University of Southampton, UK.
The entire cohort is being followed up through primary care and hospital records for clinical outcomes including incident coronary heart disease, cerebrovascular disease, chronic airflow obstruction and fracture. The cohort members are flagged with NHS Digital for notification of deaths.
HCS is part of CLOSER (Cohort & Longitudinal Studies Enhancement Resources) which aims to maximise the use, value and impact of the UKs longitudinal studies.
Last update: 31/01/2017",HBC,"Collection of health data available on 3,000 children (up to age 5) born during 1931-1939 that still reside in Hertfordshire (UK). Follow up began in 1990 and includes additional health data through medical records.",1998-2003,"1 to 4,999","Professor Cyrus Cooper","http://www.mrc.soton.ac.uk/cohorts/hertfordshire/|http://www.mrc.soton.ac.uk/herts/","hcs@mrc.soton.ac.uk","+44 (0) 23 8077 7624","University of Southampton
Southampton General Hospital
Southampton
SO16 6YD","Medical Research Council",1998-2003,1750,59-73,,,,"No diagnosis","United Kingdom",,"0 to 4,999","40 to 59|60 to 100","Behaviour|Cognitive function|Mental health|Neurological","Individual physiological","Blood pressure|Height|Waist circumference|Weight",Cardiovascular|Musculoskeletal|Respiratory,Blood|Other|Urine,"Gene screening",,,"Alcohol|Dietary habits|Physical activity|Smoking","Education|Ethnic group|Family circumstances|Housing and accommodation|Informal support|Marital status|Occupation and employment","Formal health and social care service utilisation including private care","University of Southampton",
"Health and Retirement Study","The University of Michigan Health and Retirement Study (HRS) is a longitudinal panel study that surveys a representative sample of approximately 20,000 people in the United States.
Last update: 21/01/2017",HRS,"The University of Michigan Health and Retirement Study (HRS) is a longitudinal panel study that surveys a representative sample of approximately 20,000 people over 50 in the United States.",1992,,"Dr David Weir","http://hrsonline.isr.umich.edu/","hrsquestions@umich.edu",,"Health and Retirement Study
The University of Michigan
Institute for Social Research
426 Thompson Street
Ann Arbor, MI 48104","National Institute of Aging (NIA)",1992,,>50,,"Alzheimer's disease|Subjective memory complaints (SMC) or subjective cognitive decline (SCD)",,"No diagnosis",USA,,"20,000 to 49,999","40 to 59|60 to 100","Behaviour|Cognitive function|Mental health|Neurological","Individual physiological|Individual psychological","Blood pressure|Height|Weight","Cardiovascular|Hearing and Vision|Musculoskeletal|Respiratory",Blood,"Gene screening",,,"Alcohol|Dietary habits|Physical activity|Smoking","Education|Ethnic group|Family circumstances|Housing and accommodation|Income and finances|Informal support|Marital status|Occupation and employment|Unpaid care","Formal health and social care service utilisation including private care","The University of Michigan",
"The Incidence of Cognitive Impairment in Cohorts with longitudinal Evaluation – PD","The ICICLE-PD study aims to accurately characterise two independent cohorts of incident parkinsonism in Newcastle-Gateshead and Cambridgeshire. A key objective is to identify patients who develop Parkinson's disease dementia (PDD) and the factors that predict its evolution. From this information, a simplified panel of tests that can be used to predict PDD will be established. ICICLE-PD will therefore provide a platform for studies investigating agents designed to help treat this complication of PD. Participants were recruited between June 2009 and March 2012. Longitudinal follow up is on going with assessments in person at 18-month intervals.
Last update: 16/01/2017",ICICLE-PD,"The ICICLE-PD study aims to accurately characterise two independent cohorts of incident parkinsonism. 318 participants over 18 were recruited between June 2009 and March 2012.","Jun 09-Mar12","0 to 4,999","Professor David Burn","http://www.ncl.ac.uk/caru/about","Alison Yarnall Email: alison.yarnall@ncl.ac.uk and Rachel Lawson Email: : rachael.lawson@ncl.ac.uk","+44 (0)191 2081279 and +44 (0) 191 2081277","Clinical Ageing Research Unit
Campus for Ageing and Vitality
Newcastle upon Tyne
NE4 5PL","Parkinson's Disease Society
Rhoda Lockhart Parkinson's Disease Research Fund","Jun 09-Mar12",318,>18,,"Mild cognitive impairment (MCI)|Parkinson's disease|Subjective memory complaints (SMC) or subjective cognitive decline (SCD)",,"Condition diagnosed","United Kingdom",,"0 to 4,999","10 to 19|20 to 39","Cognitive function|Mental health|Neurological","Caregiver|Individual physiological","Blood pressure|Height|Hip circumference|Waist circumference|Weight","Cardiovascular|Hearing and Vision","Blood|Cerebral spinal fluid (CSF)|CSF biomarker data available","Gene screening","Magnetic resonance imaging (MRI)|Positron emission tomography (PET) fluorine18 flurodeoxyglucose (FDG)","Consent for brain donation","Alcohol|Physical activity|Smoking","Education|Housing and accommodation|Marital status|Occupation and employment|Unpaid care",,"Newcastle University",
"Lothian Birth Cohort 1936","The participants of the Lothian Birth Cohort 1936 were recruited to the project because they had taken part in the Scottish Mental Survey 1947. This followed the Scottish Mental Survey of 1932 from which the Lothian Birth Cohort 1921 was established.
The surveys had, respectively, tested the intelligence of almost every child born in 1921 or 1936 and attending school in Scotland in the month of June in those years. Tracing, recruiting and re-testing people who had taken part in the Surveys offered a rare opportunity to examine the distribution and causes of cognitive ageing across most of the human life course.
The LBC1936 began in 2004 and recruited 1091 of the 70,805 individuals who had taken part in the 1947 survey. The LBC1936 have been examined at mean ages of 70, 73, 76 and 79 years. The cohort has a wide range of variables: genome-wide genotyping, demographics, psycho-social and lifestyle factors, cognitive functions, medical history and examination, biomarkers (from blood and urine) and a detailed structural magnetic resonance imaging (MRI) brain scan.
Last update: 08/12/2016",LBC1936,"The LBC1936 began in 2004; it recruited 1091 participants from the Scottish Mental Survey 1947. The focus of the study is cognitive ageing and encompasses a wide range of variables.",1947,"0 to 4,999","Professor Ian Deary","http://www.lothianbirthcohort.ed.ac.uk/","PI Email: Ian.Deary@ed.ac.uk",,"Department of Psychology
The University of Edinburgh,
7 George Square,
Edinburgh,
Scotland,
EH8 9JZ","Age UK
Medical Research Council (MRC)",1947,1091,11,,,,"No diagnosis","United Kingdom",,"0 to 4,999","0 to 9|10 to 19|20 to 39|40 to 59|60 to 100","Behaviour|Cognitive function|Mental health|Neurological","Individual physiological|Individual psychological","Blood pressure|Height|Weight","Cardiovascular|Hearing and Vision|Musculoskeletal|Respiratory",Blood|Other|Urine,"Gene screening","Magnetic resonance imaging (MRI)","Consent for brain donation","Alcohol|Dietary habits|Physical activity|Smoking","Education|Ethnic group|Family circumstances|Housing and accommodation|Marital status|Occupation and employment|Unpaid care",,"University of Edinburgh",
"Oxford Parkinson Disease Centre Discovery Cohort","The OPDC Discovery cohort is a prospective, longitudinal study that has recruited patients with early idiopathic Parkinson Disease, healthy controls and participants at risk of PD. The study also includes participants with REM Sleep Behaviour Disorder. Over 1500 subjects have been recruited to the cohort, including 1087 people with Parkinson's, 300 healthy controls, 111 First degree PD relatives and 151 PSG-diagnosed REM sleep behaviour disorder, thought to be 'at-risk' of developing future Parkinson's. All patients have a clinical assessment repeated every eighteen months so we can better understand the progression of Parkinson's over time. Over 500 patients have been seen for a second visit which has allowed us to identify some important differences in the way Parkinson's progresses in different people.
Last update:29/12/2016","OPDC Discovery","The OPDC Discovery cohort is a prospective, longitudinal study that has recruited 1,500 patients between 2010-2015 with either early idiopathic Parkinson Disease, as healthy controls or as participants at risk of PD. The aim is to better understand Parkinson's over time.",2010-15,"0 to 4,999","Dr Michele Hu","http://opdc.medsci.ox.ac.uk/home","opdc.administrator@dpag.ox.ac.uk","+44 (0) 1865 282358","Oxford Parkinson's Disease Centre,
Department of Physiology,
Anatomy and Genetics,
Le Gros Clark Building,
South Parks Road,
Oxford,
OX1 3QX","Parkinson's UK
The Monument Trust",2010-15,1311,>18,,"Parkinson's disease",,"Condition diagnosed","United Kingdom",,"0 to 4,999","10 to 19|20 to 39","Behaviour|Cognitive function|Mental health|Neurological","Caregiver|Individual physiological|Individual psychological","Blood pressure|Height|Weight",Cardiovascular|Respiratory,"Blood|Cerebral spinal fluid (CSF)|CSF biomarker data available","Gene screening","Magnetic resonance imaging (MRI)","Consent for brain donation","Alcohol|Dietary habits|Physical activity|Smoking","Education|Ethnic group|Family circumstances|Housing and accommodation|Income and finances|Marital status|Occupation and employment|Unpaid care",,"University of Oxford",
"The Millennium Cohort","The Millennium Cohort Study (MCS) is a multi-disciplinary research project following the lives of around 19,000 children born in the UK in 2000-01. It is the most recent of Britain's world-renowned national longitudinal birth cohort studies. The study has been tracking the Millennium children through their early childhood years and plans to follow them into adulthood. It collects information on the childrens siblings and parents. MCS's field of enquiry covers such diverse topics as parenting; childcare; school choice; child behaviour and cognitive development; child and parental health; parents employment and education; income and poverty; housing, neighbourhood and residential mobility; and social capital and ethnicity.
The children and families have been contacted 6 times since recruitment at ages nine months, 3, 5, 7, 11 & 14 years.
MCS is part of CLOSER (Cohort & Longitudinal Studies Enhancement Resources) which aims to maximise the use, value and impact of the UK's longitudinal studies.
Last update: 16/01/2017",MCS,"MCS is a population cohort study looking at the health and social data of 19,000 millennium children (born in 2000-01) through their early years.",2000-02,"20,000 to 49,999","Professor Emla Fitzsimons","http://www.cls.ioe.ac.uk/mcs","clsfeedback@ioe.ac.uk","+44 (0)20 7612 6875","Centre for Longitudinal Studies
UCL Institute of Education
20 Bedford Way
London
WC1H 0AL","Economic and Social Research Council",2000-02,23610,>0,,,,"No diagnosis","United Kingdom",,"20,000 to 49,999","0 to 9|10 to 19|20 to 39|40 to 59|60 to 100","Behaviour|Cognitive function|Mental health",,"Height|Waist circumference|Weight","Cardiovascular|Hearing and Vision|Musculoskeletal|Respiratory",Saliva,,,,"Alcohol|Physical activity|Smoking","Education|Ethnic group|Family circumstances|Housing and accommodation|Marital status|Occupation and employment|Unpaid care",,"Centre for Longitudinal Studies",
"Newcastle 85+","In May 2006 a multidisciplinary team in the Institute for Ageing and Health at Newcastle University began a major groundbreaking study of the lives of those aged 85 years and older.
The study aimed to:

Assess, in great detail, the spectrum of health in the oldest old.

Examine the associations of health trajectories and outcomes with biological, clinical and social factors as the cohort ages.

Identify factors which contribute to the maintenance of health and independence.

Advance understanding of the biological nature of human ageing.

Eligible individuals will be all those who turn 85 during the year 2006 (i.e. born in 1921) and who are registered with a Newcastle or North Tyneside general practice. Participants will be visited in their current residence (own home or institution) by a research nurse at baseline, 18 months and 36 months. The assessment protocol entails a detailed multi-dimensional health assessment together with review of general practice medical records. Participants will be flagged with the NHS Central Register to provide details of the date and cause of death.
Last update: 17/01/2017",,"Newcastle 85+ is a longitudinal study looking at the health of the oldest old. In May 2006 1,042 participants aged 85 and were registered with a Newcastle or North Tyneside general practice were recruited.",2006,"0 to 4,999","Dr Rachel Duncan","http://research.ncl.ac.uk/85plus/","Carol.jagger@ncl.ac.uk","+44 (0) 191 2081117","Professor Carol Jagger
Biogerontology Research Building,
Institute of Health and Society,
Newcastle University Institute for Ageing,
Newcastle University,
Campus for Ageing and Vitality,
Newcastle upon Tyne,
NE4 5PL.","Medical Research Council (MRC)
Biotechnology Biological Sciences Research Council (BBSRC)
Dunhill Medical Trust
Newcastle University",2006,294,>85,,,,"No diagnosis","United Kingdom",,"0 to 4,999","60 to 100","Cognitive function|Mental health","Individual physiological","Blood pressure|Height|Hip circumference|Waist circumference|Weight","Cardiovascular|Hearing and Vision|Musculoskeletal|Reproductive|Respiratory",Blood,,,,"Alcohol|Dietary habits|Physical activity|Smoking","Family circumstances|Income and finances|Informal support|Occupation and employment","Formal health and social care service utilisation including private care","Newcastle University",
"MRC National Survey of Health and Development Cohort /1946 Birth Cohort","The NSHD has informed UK health care, education and social policy for more than 70 years and is the oldest and longest running of the British birth cohort studies. Today, with study members in their seventies, the NSHD offers a unique opportunity to explore the long-term biological and social processes of ageing and how ageing is affected by factors acting across the whole of life. From an initial maternity survey of 13,687 of all births recorded in England, Scotland and Wales during one week of March, 1946, a socially stratified sample of 5,362 singleton babies born to married parents was selected for follow-up. This sample comprises the NSHD cohort and participants have been studied 24 times throughout their life.
During their childhood, the main aim of the NSHD was to investigate how the environment at home and at school affected physical and mental development and educational attainment. During adulthood, the main aim was to investigate how childhood health and development and lifetime social circumstances affected their adult health and function and how these change with age.
Now, as participants reach retirement, the research team is developing the NSHD into a life course study of ageing. Study members completed a postal questionnaire in 2014 and participated in a home visit in 2015/16, where data on health, lifestyle and life circumstances as well as obtaining repeat physical and cognitive measurements were collected. Over the past two years, a subset of 500 study members were invited to participate in a neuroimaging sub-study and over the next two years they will be recalled for a follow-up. This study will be conducted in collaboration with the Institute of Neurology, UCL.
NSHD is part of CLOSER (Cohort & Longitudinal Studies Enhancement Resources) which aims to maximise the use, value and impact of the UK's longitudinal studies.
NSHD is part of the Dementias Platform UK (DPUK), a multi-million pound public-private partnership to accelerate progress in dementias research http://www.mrc.ac.uk/research/facilities/dementias-platform-ukLast update: 19/12/2016","NSHD/ 1946BC","NSHD is a population cohort which began in March 1946, 13,687 participants born in one week of March in 1946 were selected. The aim of the study has evolved and is now focused on ageing.",1946,"0 to 4,999","Professor Nish Chaturvedi","http://www.nshd.mrc.ac.uk","General enquiries: mrclha.enquiries@ucl.ac.uk Data access: mrclha.swiftinfo@ucl.ac.uk","+44 (0) 20 7670 5700","MRC Unit for Lifelong Health and Ageing at UCL
33 Bedford Place
London WC1B 5JU
UK","Medical Research Council",1946,2800,0,,"Dementia (unclassified)|Subjective memory complaints (SMC) or subjective cognitive decline (SCD)",,"No diagnosis","United Kingdom",,"5,000 to 9,999","0 to 9|10 to 19|20 to 39|40 to 59|60 to 100","Cognitive function|Mental health|Neurological","Caregiver|Individual physiological|Individual psychological","Blood pressure|Height|Hip circumference|Waist circumference|Weight","Cardiovascular|Hearing and Vision|Musculoskeletal|Respiratory",Blood|Other|Saliva|Urine,"Gene screening","Magnetic resonance imaging (MRI)|Positron emission tomography (PET) - amyloid","Consent for brain donation","Alcohol|Dietary habits|Physical activity|Smoking","Education|Ethnic group|Family circumstances|Housing and accommodation|Income and finances|Informal support|Marital status|Occupation and employment|Unpaid care","Formal health and social care service utilisation including private care","University College, London",