In 2009, Holden appeared as Lizzie, the Ring Mistress in the BBC sitcom Big Top. In April 2009, it was reported that the US network CBS had offered Holden the job of one-time guest presenter on The Early Show, a daytime talk show. On 1 June 2009, she appeared with regular presenters Harry Smith and Maggie Rodriguez. Holden has since signed up with CBS as a British correspondent for The Early Show.

From 2009 until 2014, Holden co-presented A Night of Heroes: The Sun Military Awards annually on ITV with Phillip Schofield. In January 2010, she presented her own four-part series, Amanda Holden's Fantasy Lives, in which she tried out four of her dream jobs including working as a showgirl in Paris and a magician's assistant in Las Vegas.

She married comedian Les Dennis in June 1995. They had a temporary split in 2000 when Holden's affair with actor Neil Morrissey[16] was exposed in the press, before eventually separating in December 2002 and divorcing in 2003. Around this time, she alleges that she was sexually assaulted by an "unnamed famous comedian" at a public event.[17] Amanda has been vegetarian since she was thirteen.[18]

On 20 January 2006, Holden gave birth to her first child with her fiancé, record producer Chris Hughes.[19] She married Hughes at Babington House,[20] Somerset, on 10 December 2008 with former Formula One racing driver David Coulthard acting as best man. After a miscarriage in 2010, she suffered their son being stillborn at seven months in 2011.[21] On 23 January 2012 she gave birth to their second daughter despite medical complications.[22]

Holden campaigned to keep a Sainsbury's supermarket out of Bishop's Waltham. Residents of her hometown later accused her of a double standard in November 2010 when she signed a deal with Tesco, the UK's largest supermarket chain.[23]

In December 2016 Holden's ancestry was the subject of a BBC programme in the Who Do You Think You Are? series.[24] The investigation revealed that her 5x great-grandfather served a year's imprisonment, after breaking his apprenticeship as a cordwainer, by enlisting in the Royal Navy. Ten years later, while serving in the British Army after the Peninsular War, he met and married a Frenchwoman and began a family near Bordeaux in South Western France, before then moving his wife and eldest children back to his home in Cornwall.[25] In addition, it transpired that her grandfather Frank Holden, a psychiatric nurse, was aboard the RMS Lancastria, when it was bombed outside the port of Saint-Nazaire and sank with the loss of thousands of lives. He committed suicide at the age of 71.[26]

Holden fronted Everton's breast cancer awareness campaign, sporting a limited edition baby pink club shirt, the colour of breast cancer awareness.[27] In September 2011, Holden was sponsored to bake a cake for every child in the Great Ormond Street Hospital.[citation needed]