Information

The program of this conference will deal with the evolution of the hematopoietic system during aging, how this evolution contributes to the development of hematological malignancies, most of which predominate in the elderly as well as the diagnosis and therapeutic management of myeloid and lymphoid hematologic malignancies at older age.

For instance, the occurrence of somatic mutations in myeloid cells appear to be early steps in the pathophysiology of myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML), and epigenetic changes and bone marrow stroma modi­ cations occurring with aging may have a pathogenetic role in this development. Clonal B lymphocytosis and monoclonal gammopathies, mainly seen in the elderly, represent early phases of chronic lymphocytic leukemia (CLL) and myeloma, respectively. Aging of the immune system contributes to the higher rate of infections seen in elderly subjects.

The program will explore potential intrinsic speci­fic characteristics of hematological malignancies as they present in patients of older age, in comparison to younger patients, and discuss the therapeutic management and specific requirements in older patients.

Special attention will be given to the utility and promise of new drugs, especially targeted drugs with reduced or no myelosuppression, that may be particularly useful in elderly patients to analyze a frequent situation in the elderly, ie anemia.

Educational Objectives:

Upon completion of this CME activity, participants should be able to:

Aging of the hematopoietic system and immune system

Early genetic events leading to the development of hematological malignancies, including AML, MDS, CLL, myeloma, and how they differ from the full blown diseases

Potential differences in disease characteristics in haematological malignancies in the elderly, as they may lead to different treatments compared to younger patients

How to assess the geriatric patients for comorbidities, functional aspects, particularly for treatment decisions

Treatments that can be used in hematological malignancies in the elderly, particularly those with no or limited myelosuppression, which may be particularly useful in patients of older age

SCIENTIFIC TOPICS:

Aging hematopoiesis

Clonal hematopoiesis and aging

The aging hematopoietic system

MDS

Acute Leukemias

Multiple myeloma, precursor lesions and management questions in the elderly

Lymphoma: clonal evolution and specific management strategies in the elderly

CLL and MBL, molecular evolution, and specific management strategies in the elderly

Please use the following password: eshmars2018

Venue

Corporate partners

With the support of

Level 2 Conference Partner

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Supporting Partners

Scholarship

SCHOLARSHIPS AVAILABLE for early career biologists and clinicians (ie. residents, doctoral students, post-doctoral students still in-train,ing as well as those fully trained who have a maximum of 4 years professional experience). The scholarship only covers the whole or part of the registration fee. Please submit an abstract and send by January 14th, 2018 to camille.frank@univ-paris-diderot.fr the following:

Cancellation policy of registration fee :In case of cancellation, up until two months prior to the beginning of the meeting, the registration fee will be reimbursed in full (less bank charges). If the cancellation is notified between 60 to 15 days prior to the beginning of the meeting, 50% of the registration fee will be reimbursed (less bank charges). Cancellations notified 15 days before the meeting will not be reimbursed.

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