MRI Histology = Smart Toxicologic Pathology

Aspect Imaging M-Series MRI assists in locating the volume and quantity of lesions in tissue. This dramatically improves the accuracy of lesion detection.

A recent paper by the FDA describes in detail the use of MRI in living animals in a neurotoxicity study. MRI was shown to dramatically improve the section selection for neuropathology study.

The automated MR Histology system can be placed in any lab, core facility or office, and the streamlined workflow transforms high-throughput 3D imaging of fixed samples into a quick, efficient and simple task for the modern toxicology lab or researcher. The system works on all M-Series systems.

Reproductive and teratology

Subcutaneous toxicity

Neurotoxicity

Location and volume measurement of toxicity-related changes

Automated histology system (inserting into magnet)

Workflow for MR Histology

Step 1

Samples are placed in
cartridges.

Fixed samples (whole organs or tissue samples) are placed in the cartridges. As MR imaging is non-destructive, the tissue remains unchanged, and routine immunohistochemistry is easily performed following the 3D MR-based histology.

Step 2

Custom bar codes are printed and samples are scanned.

The system produces unique bar code stickers which are applied to each cartridge. The cartridge is scanned and the study software brought up, which allows the operator to enter study-specific and sample-specific data. The appropriate imaging protocol is selected and associated with the sample bar code.

Step 3

Up to 9 cartridges
are pre-loaded.

The “auto-loader” allows up to 9 cartridges to be pre-loaded. A sample is advanced into the system, its bar code is read and the appropriate protocol run. The next sample is automatically advanced, starting the process again.

Step 4

Easy-to-manage high-throughput 3D MR-based histology

The system can automatically generate high-resolution 3D data sets of up to 10 samples. A quick sample can be run in a few minutes, or can be set-up and the samples run overnight, unattended.

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