Tag: "knockout" at biology news

... a little disappointing at first," Chen says. "The knockout mice seemed to have the same reactions to painful ...ehavior in two sets of mice — normal mice and GRPR knockout mice. Normal mice scratched vigorously when exposed to a variety of itch-producing substances, but t...

...rotein production or gene regulation rarely suffer knockout hits. Genes that are important for the interaction with other organisms, on the other hand, such as those responsible for defense against pathogens or infections, are much more variable than the average gene. "The genetic variability appears to refle...

... genes more easily and inexpensively than existing knockout techniques, Wu says. In their study, Wu and Capecchi demonstrated that by using a jumping gene to mutate a mouse gene involved in bone formation, resulting in mutant mice with abnormally short limbs and tail (see photo with this news release)....

...es has been based on the Drosophila model and Per2 knockout mice," which lack the Per2 clock gene altogether, added study author Ying-Hui Fu, who is also at UCSF. Based on those studies, "everybody had thought a short or long period depended on a change in protein stability," she said. "That's how we thoug...

...hown by study of one of the world’s first microRNA knockout mouse, reported Friday 27 April in Science. The mi...lar vital role. Cells of the immune system in the knockout mice do not work as well as normal cells and the mice develop symptoms similar to those of human aut...

...n that mice that lack the gene for SH2B1 -- called knockout mice -- become obese, diabetic, and unable to stop...pletely corrected the metabolic disorders that the knockout mice had developed, but also improved the brain cells?ability to respond to leptin signals and produ...

...l create the genetic material that will be used to knockout or "inactivate" mouse genes. Scientists at the Wellcome Trust Sanger Institute in Hinxton, England will insert the altered genes into the embryonic stem cells derived from the mice. UC Davis will use the altered embryonic stem cells to create adult...

...their regenerative potential. "At two weeks, the knockout animals' brains had developed a big hole," said Yuh-Nung Jan, a Howard Hughes Medical Institute investigator at the University of California, San Francisco. "We thought that the mice would not live long, but by four weeks, the hole was largely repair...

...ecific proteins were missing in the thymus of Aire knockout mice. The team then went on to show that IRBP was...d in the thymus under the control of Aire and that knockout mice lacking the IRBP protein were protected from the disease because they don't express the protein...

...ecific proteins were missing in the thymus of Aire knockout mice. The team then went on to show that IRBP was...d in the thymus under the control of Aire and that knockout mice lacking the IRBP protein were protected from the disease because they don't express the protein...

... loss of vessel tone as the primary defect in Klf2 knockout mice. Now that Klf2 has been established as an important regulator of blood flow in live animals and is required for the development of a healthy cardiovascular system, the next step is to elucidate the role of Klf2 in normal adult blood vessels ...

... cells in a mouse missing the Aire gene. That Aire knockout is a good model for humans with APS1. They found significantly fewer i NKT cells in the thymus, spleen, liver and bone marrow and severely impaired maturation of those cells in mice missing the Aire gene. And the mice given alpha-GalCer had signif...

...s. In their experiments, the researchers gave the knockout mice eight weeks of daily doses of AF267B and test...mice performed significantly better than untreated knockout mice on the task. Significantly, found the researchers, the poorer performance of the untreated mic...

...function of the hypothalamus. In experiments with knockout mice in which the Hap1 gene was eliminated, the mice failed to eat after birth. In addition, deleting Hap1 caused degeneration of some neurons in the hypothalamus. In order to find out more about the function of Hap1 and the neural pathways it empl...

...ut the p11 gene in mice. Compared to control mice, knockout mice had fewer receptors at the cell surface, redu...depression-like. Also, the 5-HT1B receptors of p11 knockout mice were less responsive to serotonin and antidepressant drugs compared to those of control mice, w...

...rchers transplanted allogenic bone marrow into the knockout mouse. According to Kalluri, within a period of a...the damaged regions of the kidney glomeruli in the knockout mouse, emerging as healthy renal cells (podocytes and mesangial cells). This led to clear improvemen...

...hen those genes can be used -- for example in gene knockout studies -- to determine what role the neurons play in reproduction and behavior," Buck said. "Understanding how the brain's neural circuitry controls behavior has been largely a black box," she said. "I think that through studies like these we and o...

... to the rat because it would enable us to generate knockout rats to do genetic studies," said Dr. Kent Hamra, assistant professor of pharmacology at UT Southwestern and lead author of the PNAS study. "It is a larger animal, it's often better for toxicology and physiology studies, and its behavior is more in t...

...ly after a shock and later after hearing the tone, knockout mice reacted less strongly, they found, suggesting...atsky said. "This evidence suggests that stathmin knockout mice can be used as a model of anxiety states of mental disorders with innate and learned fear compo...

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