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A chronic remitting, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue with an autoimmune basis. The classic symptom is a facial butterfly rash, although this can occur with other forms of lupus (see lupus erythematosus). The antigens are often nuclear (often anti-RNA) and multiple suceptibility loci have been identified. Resistance to systemic lupus erythematosus is associated with a polymorphism in the toll-like receptor-5 gene.