Bush was president during the final months of Star Trek: Voyager's run and the entire run of Star Trek: Enterprise. To date, he is the most recent real-life US president referenced in any canon Star Trek production.

According to Benedict Cumberbatch, Star Trek Into Darkness has "a massive sort of comment about post-Bush/Cheney era foreign policy and the legacy from that." [1]Simon Pegg said "Writers always tend to externalize what's going on in everyone's mind. There is a parallel with the terrorist activities of Osama bin Laden and the decision to attack Iraq. Iraq had nothing proven to do with 9/11, and yet Bush used that as an excuse to start a war with those people. You can always see the Klingons as like Iraq and John Harrison the proxy for Osama bin Laden." [2]