2

Absolutely:
There is a well know interaction between plavix and proton pump inhibitors. Plavix is a prodrug(inactive) and is activated in the liver. This process of activation is blocked by proton oump inhibitors. Specifically with nexium and prilosec, also somewhat with other ppis. The only one safe to use is dexilant (dexlansoprazole) and possibly protonix. Or change plavix to effient or brilinta under guidance of MD
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10

Depends:
It depends on why your take it. If you take it because you have an ulcer or precancerous changes in the lining of your esophagus or stomach then i would encourage you to keep taking it. If however, it's just for reflux/heartburn you can try the things recommended on this link: http://www.Mayoclinic.Com/health/heartburn-gerd/ds00095/dsection=lifestyle-and-home-remedies.
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