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In the body it is converted to tetrahydrofolic acid, as a coenzyme, is involved in various metabolic processes, and necessary for the normal maturation and education megaloblasts normoblasts. At deficiency of folic acid developed Megaloblastic type of hematopoiesis. Stimulates erythropoiesis, is involved in the synthesis of amino acids (including methionine, serine, glycine), nucleic acids, purines, pyrimidines, exchangeable choline, histidine. When pregnancy is protective in relation to the action of teratogenic and damaging fast acting testosterone mix the fruit of factors. It promotes normal maturation and function of the placenta.

Pharmacokinetics: after oral administration of folic acid, connecting the stomach to the intrinsic factor (a specific glycoprotein), well and completely absorbed in the digestive tract. Almost completely bound to plasma proteins. Deposited in the liver and metabolized primobolan side effects to form tetrahydrofolic acid (in the presence of ascorbic acid by the enzyme dihydrofolate reductase). It penetrates through the blood-brain barrier, the placenta and breast milk. Cmax in the blood is achieved in 30-60 minutes. Excreted by the kidneys in unchanged form (if the received dose considerably higher than the daily requirement), and in the form of metabolites.Displayed by hemodialysis. 5 mg of an oral folic acid excreted from the body within 5 hours.

Indications for use:

treatment and prevention of folate deficiency on the background of an unbalanced or malnutrition;

Contraindications:

Dosage and administration:

for the treatment of megaloblastic anemia due to deficiency of folic acid: 5 mg per day for 4 months, the prevention – 2.5 mg per day.

for the prophylaxis and treatment of macrocytic anemia in sprue, inflammatory bowel disease, and defective or unbalanced pitanii- to 15 mg per day to patients with the disease sprue – 5-15 mg per day.

for the prevention of fetal neural tube defects – 2.5 mg per day for 4 weeks prior to pregnancy and continue reception for I trimester.

Higher maintenance doses can be administered tren ace to patients suffering from alcoholism, as well as patients with chronic infections and receiving anticonvulsants.

Side effects: It is possible manifestation of allergic reactions (skin rash, pruritus, erythema, bronchospasm); on the part of the digestive tract: anorexia, nausea, abdominal distention, bitter taste in the mouth.

Interaction with other medicinal products: In an application with chloramphenicol, neomycin, polymyxin, tetracycline folate intake decreases. With simultaneous use of folic acid reduces the contraceptive effects of ingestion, ethanol, sulfasalazine, cycloserine and glutetimid, methotrexate, phenytoin, primidina, chloramphenicol. The use of folic acid may reduce the plasma levels of phenobarbital, phenytoin and primidone, and cause an epileptic seizure.Cases of reduction or changes letrozol in absorption may occur, while the use of cholestyramine and folic acid, therefore, folic acid should be taken 1 hour before or 4-6 hours after cholestyramine.

standardized extract of testosterone mix injections bilberry anthocyanins with a high concentration, the major carotenoids (lutein, lycopene and beta-carotene), vitamins and zinc. Brochure with a set of exercises that improve the microcirculation of the eye tissue. To reduce the risk of age-related eye diseases.

with degenerative changes in the retina;

in violation of twilight vision;

with varying degrees of myopia

when working at the computer.ACTWhen taken regularly correcting system Focus normal supply of the eye with useful substances and improves microcirculation in the eye tissues, thereby:

reduced eye fatigue at high visual loads;

preventing the progression of myopia and retinal diseases;

improving the basic visual functions: visual acuity, color vision, contrast sensitivity and twilight vision, expanding the boundaries of the peripheral field of vision;

prevent and slow down age-related changes testosterone mix injections of the retina.RECOMMENDATIONS FOR USEAdults and children over 14 years: 1 capsule per day during meals.

The recommended course of reception focus – 40-60 days (2-3 package).

If necessary, or on the advice of a specialist receiving repeat the course.

The number of courses is not limited to the reception.

CONTRAINDICATIONS

Individual intolerance of individual components.

SYSTEMATIC APPROACH TO THE IMPROVEMENT OF

For those who want to increase the positive effect of the drug, we offer a systematic approach to improve the view. The Focus package enclosed brochure with description of special exercises for the eyes. Their implementation has two-way action: firstly, strengthens muscles of the eye, and secondly, it improves microcirculation in the eye tissues, and hence the inflow of nutrients to the eyes.

To assess the dynamics of change in tkit also includes a table for testing visual acuity. However, it should be remembered that the improvement occurs gradually, not immediately. Experts recommend checking the vision several times a year, depending on the visual load.

COMPOSITION

The composition of was developed jointly with the Institute s. Included synergistic substances, ie increase the effect of each other.

LUEBERRY EXTRACT: PROVEN QUALITYHow to determine whether the benefit of visually impaired bring a drug with blueberries?Much of this depends on how much blueberry anthocyanins it contains. Anthocyanins – a special substance, defining, in particular, the color of berries. That blueberry anthocyanins have a positive impact on the work of the eye.

The dried berries blueberry anthocyanin concentration is very low (around 0.5%). Therefore, to testosterone mix injections increase the effect of taking the drugs to the eye, it is advisable not to use dried bilberry, the extract of the berries.

The content of anthocyanin extract is much higher: the maximum possible concentration reaches 25%. Modern technologies allow to cook strictly adjusted (standardized) extracts which have a constant concentration of anthocyanins per unit mass.

In Focus used only standardized extract of bilberry anthocyanins with a high content (25%).

For the prevention of anaphylactoid reactions during glazmafereza receiving inhibitor is temporarily stopped prior to the procedure.
Angioneurotic edema of the face, extremities, lips, mucous membranes, tongue, vocal cords, and / or larynx may develop during treatment with preventivo kondome mix testosterone inhibitors, particularly during the first few weeks of treatment. In rare cases, severe angioedema may occur against the background of a prolonged use of the drug. In such cases, fosinopril should be lifted immediately and apply anti-hypertensive drug other pharmacological class.
In patients with hypertension, symptomatic hypotension with the use inhibitors most often develops after intensive treatment with diuretics, diet, limiting sodium chloride, against diarrhea, vomiting, or in patients on hemodialysis.
in patients with heart failure with concomitant renal failure or without increasing the risk of a sharp decline in blood pressure in the background of hyponatremia after previously conducted intensive diuretic therapy, as well as in elderly patients.
Temporary hypotension is not a contraindication for the use of the drug after of measures aimed at increasing the bCC. To reduce the risk of symptomatic hypotension in patients who take diuretics, it is recommended to stop taking them 2-3 days prior to treatment , If unable to cancel diuretics, treatment should start with the lowest dose of 10 mg. Further dose escalation is under the control of blood pressure.
In some patients with heart failure, who initially had normal or low blood pressure, with the start of drug administration further moderate reduction in systemic blood pressure, which is a common effect at the beginning of the drug.
During the application may cause a dry cough, which disappears after discontinuation of the drug. If necessary, treatment can be continued.
In the case of jaundice or a significant increase in activity of “liver” enzymes, inhibitors should be stopped and to provide the patient a thorough medical examination.
While receiving inhibitors rarely observed intestinal mucosa swelling, often in the absence of nausea and vomiting, which disappeared after discontinuation inhibitors. Swelling of the intestinal mucosa should be considered in the differential diagnosis in patients complaining of abdominal pain that has developed during treatment with preventivo kondome mix testosteroneinhibitors.
When surgery (general anesthesia), thus enabling the development of arterial hypotension.
It should inform the anesthetist about the use if patient planned for anesthesia or surgery. Treatment inhibitor should be discontinued one day prior to surgery.
Patients receiving , caution should be exercised during exercise or in hot weather because of the risk of development of dehydration and hypotension due to a decrease.
It is not recommended to use the together with lithium therapy. If necessary, the use of such a combination is necessary to monitor the concentration of lithium in blood plasma.
In children and adolescents under the age of 18 years (safety and efficacy not established).

Effects on ability to drive vehicles and working with machinery
Use caution while using the preventivo kondome mix testosteronedue to the potential for adverse reactions that may adversely affect the ability to road management and the performance of potentially hazardous activities that require high concentration and speed of psychomotor reactions .

Marked reduction of blood pressure, shock, stupor, bradycardia, disturbance of water and electrolyte balance, renal failure, temporary hyperventilation, tachycardia, palpitations, dizziness, anxiety and cough. Treatment: The patient should be placed in intensive care, with careful monitoring serum electrolytes and creatinine. To reduce the absorption of the drug must gastric lavage purpose adsorbents and sodium sulfate for 30 minutes after administration of fosinopril. In the case of significant decrease of blood pressure put a patient with raised feet on the bed and make a rapid intravenous mix lidocaine with testosterone administration of 0.9% sodium chloride solution in / in the introduction of catecholamines. In severe bradycardia – atropine sulfate, in some cases, it may require the use of an artificial pacemaker.

The interaction with other drugs
Diuretics, ethanol, nitroglycerin, other nitrates and vasodilators fosinopril enhance the antihypertensive effect of the drug.
With simultaneous use of drugs with potassium fosinopril, heparin, potassium-sparing diuretics (including with amiloride, spironolactone, triamterene), with additives to foods containing potassium, increases the risk of hyperkalemia, especially in patients with heart failure and diabetes.
Concomitant use of antacids (including aluminum hydroxide, magnesium hydroxide, simethicone), may reduce the absorption inhibitor.
in the application inhibitors of the enzyme with drugs lithium may reversible increase in the concentration of lithium in blood plasma and, accordingly, increase the risk of its toxic effects.
reduce the antihypertensive effect inhibitors, rendering thus a synergistic effect on the increase of potassium in the blood plasma, but also can cause renal dysfunction.
Simultaneous use inhibitors and drugs that reduce the concentration of glucose in the blood (insulin, hypoglycemic agents for oral administration) may cause a further decrease in the concentration of glucose in blood and the risk of hypoglycemia, particularly in the first weeks of treatment and in patients with renal insufficiency.
Simultaneous use of certain tricyclic antidepressants, antipsychotics agents, anesthetics (including opioid analgesics and drugs for general anesthesia) inhibitors may result in further reduction of blood pressure and the development of orthostatic hypotension,
Sympathomimetics reduce the antihypertensive effect inhibitors. While the use of immunosuppressants, cytotoxic drugs: corticosteroids for systemic use, allopurinol and procainamide, there is a risk of leucopenia.
Fosinopril may understate the rates of serum digoxin concentrations.

Cautions
Before using the and during the reception should be carefully monitored blood pressure, renal function, the number of blood cells, the potassium content, the concentration of creatinine and glucose in the blood serum.
In just a few days before the start of therapy spent earlier antihypertensive treatment should be discontinued.
patients with severe chronic heart failure III and IV functional class mix lidocaine with testosterone classification, as well as patients of other risk groups, treatment should be started under medical supervision.
patients with impaired water and electrolyte balance recommended the correction of water and electrolyte abnormalities prior to treatment , patients treated with insulin or hypoglycemic agents for oral administration, while taking inhibitors need to monitor the concentration of glucose in the blood, especially during the first month of use.
if conditions accompanied by a decrease in the bcc (diuretics, salt-free diet, vomiting, diarrhea, hemodialysis), reninzavisimoy hyponatremia, cerebrovascular disease, ischemic heart disease increases the risk of a sharp decline in blood pressure, If renovascular hypertension, bilateral renal artery stenosis or stenosis of the artery only functioning kidney is increased risk of severe hypotension and pitting failure.Also, during treatment with mix lidocaine with testosterone inhibitors may increase the concentration of urea nitrogen and serum creatinine. These effects usually occur in patients with renal insufficiency, they are reversible and disappear after cessation of treatment.
At the systemic connective tissue diseases (systemic lupus erythematosus, scleroderma) and therapy of immunosuppressants (including after kidney transplantation) increases the risk of neutropenia, agranulocytosis.
When hyperkalemia. stenosis of the aortic valve, hypertrophic obstructive cardiomyopathy, heart failure III and IV functional class classification, for the treatment of hypoglycemic agents in patients at risk of hypoglycaemia increases with diabetes.
In patients receiving mix lidocaine with testosterone inhibitors may increase potassium in the blood serum, in patients at risk hyperkalemia, namely in patients with renal insufficiency, uncontrolled diabetes mellitus, host kaliysberegayushie diuretics, potassium supplements or other drugs, the reception of which can lead to an increase of serum potassium (eg heparin), may cause hyperkalemia.
in hemodialysis using vysokoprotochnyh poliakrilnitrilozyh membrane plasmapheresis with the use of dextran sulfate in patients with elevated low-density lipoprotein, as well as the specific desensitisation to bee venom increases the risk of allergic reactions.

Pregnancy and lactation
The drug-Fosinopril Teva is contraindicated in pregnancy. The use inhibitors in the II and III trimester of pregnancy causes damage or even death of the developing fetus. In identifying pregnancy fosinopril treatment should be discontinued immediately. For infants whose mothers took mix testosterone propionate powder inhibitors during pregnancy, careful monitoring is recommended for early detection of arterial hypotension, oliguria and hyperkalemia.
Since fozinoprilat excreted in breast milk, if necessary, use Teva-Fosinopril should stop breastfeeding.

Dosing
Inside. The tablet is swallowed, without chewing, with a glass of water, regardless of the meal, preferably at the same time.
If you forget to receiving one or more doses of the drug to the next reception-Fosinopril Teva should be taken at the usual dose; take a higher dose should not be. Hypertension. The recommended starting dose is 10 mg 1 time per day. Then the dose is adjusted depending on the dynamics of lowering blood pressure; in the absence of the desired therapeutic effect within 3-4 weeks, the dose can be increased.Maintenance doses ranging from 10 mg up to a maximum dose of 40 mg 1 time per day. With the use of inhibitors in patients receiving diuretic therapy, may experience a sharp drop in blood pressure, which is recommended for the prevention stop taking diuretics 2-3 days before the expected start of fosinopril therapy. If unable to cancel the diuretics mix testosterone propionate powder should be used in an initial dose of 10 mg 1 once a day. Patients with high activity of the (especially in patients with renovascular hypertension, disorders of water and epektrolitnogo balance, decompensated heart failure, or severe hypertension) because of the possibility of a sudden drop in blood pressure treatment with Fosinopril-Teva is recommended to start under a doctor’s supervision. Chronic heart failure. The recommended starting dose is 1 to 10 mg once a day. Starting treatment should be supervised by a doctor. With good endurance increase the dose at weekly intervals, increasing it to 40 mg 1 time per day. For the treatment of chronic heart failure drug-Fosinopril Teva is usually combined with a diuretic and, if necessary, cardiac glycosides. Elderly patients are differences in the efficacy and safety of drug treatment in elderly patients aged 65 years or older and younger patients are not observed. However, we can not exclude a great sensitivity in some elderly patients to the drug, due to the possible effects of an overdose due to delayed elimination of fosinopril, in patients with impaired renal function or hepatic reduction in dose-Fosinopril Teva is not usually required.

Side effects:
The frequency of side effects is classified in accordance with the recommendations : very often-not less than 10%; often – at least 1% but less than 10%; infrequently – at least 0.1% but less than 1%: rare – less than 0.01% but less than 0.1%; very rare (including isolated cases) – less than 0.01%, the part of the hematopoietic system and lymphatic system: rarely – transient decrease in hemoglobin or hematocrit; rarely – eosinophilia, leukopenia, thrombocytopenia, neutropenia, lymphadenopathy; very rarely – agranulocytosis. On the part of metabolism: rarely – decreased appetite, current worsening of gout, hyperkalemia. On the part of the central nervous system: often – dizziness, headache; rarely – depression, paresthesia, somnolence, stroke, cerebral ischemia, tremor, insomnia, taste disturbances; seldom – a speech disorder, memory impairment, confusion, disorientation. From a sight organ: seldom-visual disturbances.