Reynolds is joined in Deadpool 2 by fellow returning actors T.J. Miller as Weasel, Brianna Hildebrand as Negasonic Teenage Warhead, Leslie Uggams as Blind Al, Stefan Kapičić as the voice of Colossus, and Karan Soni as Dopinder, with newcomers Zazie Beetz as Domino, Josh Brolin as Cable, Julian Dennison in an unknown role, and Jack Kesy as a villain widely thought to be Black Tom Cassidy.

Directed by David Leitch (John Wick), Deadpool 2 is in production now in Victoria, British Columbia. The film opens June 1, 2018.