Quantitative Biology > Genomics

Abstract: Summary: BWA-MEM is a new alignment algorithm for aligning sequence reads or
long query sequences against a large reference genome such as human. It
automatically chooses between local and end-to-end alignments, supports
paired-end reads and performs chimeric alignment. The algorithm is robust to
sequencing errors and applicable to a wide range of sequence lengths from 70bp
to a few megabases. For mapping 100bp sequences, BWA-MEM shows better
performance than several state-of-art read aligners to date.
Availability and implementation: BWA-MEM is implemented as a component of
BWA, which is available at this http URL.
Contact: hengli@broadinstitute.org