Cancer Biology

Raymond W. Ruddon, M.D.

Cancer Biology

Fourth Edition

Raymond W. Ruddon, M.D.

Description

A thorough yet concise account of cancer biology, this book emphasizes the cellular and molecular mechanisms involved in the transformation of normal into malignant cells, the invasiveness of cancer cells into host tissues, and the metastatic spread of cancer cells in the host organism. It also defines the fundamental pathophysiological changes that occur in tumor tissue and in the host animal or patient. The approach throughout the book is to discuss the historical development of a field, citing the key experimental advances to the present day, and to evaluate the current evidence that best supports or rules out concepts of the molecular and cellular mechanisms regulating cancer cell behavior. For all the areas of fundamental cancer research, an effort has been made
to relate basic research findings to the clinical disease states. The book is well illustrated with schematic diagrams and actual research data to demonstrate points made in the text, and there is an extensive, up-to-date bibliography.

In this revision, Dr. Ruddon has organized his text to provide more integrated discussion of the many topics covered in the third edition. At the same time, he has included much new material on molecular genetics and genetic diagnosis (e.g., DNA microarrays to mark tumors), RNA interference, stem cells, cell cycle regulation, angiogenesis, etc.

Cancer Biology

Raymond W. Ruddon, M.D.

Table of Contents

1. Characteristics of Human Cancer2. Causes of Cancer3. The Epidemiology of Human Cancer4. The Biochemistry and Cell Biology of Cancer5. Molecular Genetics of Cancer6. Tumor Immunology7. Cancer Diagnosis8. Sequelae of Cancer and Its Treatment9. Cancer PreventionIndex

Cancer Biology

Fourth Edition

Raymond W. Ruddon, M.D.

Reviews and Awards

"Provides a thorough, yet concise review of the cellular and molecular mechanisms involved in the transformation of normal into malignant cells...Clearly written and well illustrated, there is also an extensive, up-to-date bibliography, making the book valuable to basic scientists, physicians, nurses, and students interested in the field."--Anticancer Research

"Excellent chapters cover the major topics in cancer biology and include extensive bibilography sections...Overall this is a well crafted book for graduate students and cancer researchers who wish to learn more about the key concepts and pathways involved in the rapidly advancing field of cancer biology."--Doody's

"Cancer Biology is a single-authored volume that contains nine chapters and over 500 pages of primary text. The author writes from a unique perspective, having assembled the first edition of this book in 1981, and he provides a historical perspective that is unusually appropriate, citing the relevant literature and reproducing some of the figures from 'classic' papers, while at the same time covering more contemporary topics with high scholarship. His narrative is exceptionally well written, interesting, and accessible...Overall, this is an extremely valuable volume that will be of great use to both students and established investigators."--David J. McConkey, MD, as reviewed in The Quarterly Review of Biology