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We share our study of the Epidermal Growth Factor receptor let-23 in C. elegans, an excellent model organism for examining fundamental questions in genetics. We hypothesise that an overactive EGF signaling suppresses lipid synthesis through different signaling pathways. However, the pathways are poorly understood. To better understand them, we study whole animal fat levels under different EGF signaling levels and the effect of EGF signaling on the activation of the sole C. elegans lipid transcription factor, SBP-1. We use mutant strains with different levels of EGF signaling to determine whole animal fat levels and SBP-1:Green Fluorescent Protein fusion location using phase and fluorescent microscopy. We also use this approach to look at other downstream and upstream pathways connected to lipid synthesis, which will further our understanding of the role lipid synthesis plays in human cancer development.

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Apr 11th, 2:30 PMApr 11th, 2:45 PM

Effect of SBP-1 Signaling in the Synthesis of Lipids in C. elegans

Science 159

We share our study of the Epidermal Growth Factor receptor let-23 in C. elegans, an excellent model organism for examining fundamental questions in genetics. We hypothesise that an overactive EGF signaling suppresses lipid synthesis through different signaling pathways. However, the pathways are poorly understood. To better understand them, we study whole animal fat levels under different EGF signaling levels and the effect of EGF signaling on the activation of the sole C. elegans lipid transcription factor, SBP-1. We use mutant strains with different levels of EGF signaling to determine whole animal fat levels and SBP-1:Green Fluorescent Protein fusion location using phase and fluorescent microscopy. We also use this approach to look at other downstream and upstream pathways connected to lipid synthesis, which will further our understanding of the role lipid synthesis plays in human cancer development.

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