In the surprise twist ending of David Fincher's frightening crime drama, star Brad Pitt (who was Paltrow's on-screen and off-screen boyfriend at the time) is led to a mysterious box in the middle of the desert by the serial killer John Doe (played by Kevin Spacey).

Fun fact: While a lifelike model of the actress' head was created for Se7en, audiences never actually get a glimpse of it in the scene (despite many viewers' incorrect memories of the movie). However, the same head was used during a graphic autopsy of Paltrow's character during a scene in Steven Soderbergh's 2011 medical thriller Contagion.