THE HOLLYWOOD REPORTER12 Ways 'Grey's Anatomy' Will Be Different in Season 12August 19, 2015 2:11pm PT by Lesley Goldberg

Shonda Rhimes as well as stars Ellen Pompeo, Caterina Scorsone and Kelly McCreary talk with THR about what to expect. To say ABC's Grey's Anatomy is going to be a lot different without leading man Patrick Dempsey would be an understatement. But as the medical drama moves into its first full season without McDreamy, the stars and producers behind the Shonda Rhimes medical drama are all looking forward to hitting the reset button. "It feels a lot different. Every time we lose someone big — when we lost Sandra Oh — when we lose anybody — it's a big shift. But a show that runs this long, you welcome those big changes," leading lady Ellen Pompeo tells The Hollywood Reporter. "It makes everything feel so much different and that's what we're looking for in season 12. We're looking for things to not stay the same. They have to stay the same to some extent but you welcome change because that's what inspires the writers, that's what inspires the actors. Change is necessary for growth."<snip>

9. Amelia is "single, not dead." Scorsone says there's still some confusion — and "twitter-pated vibes" between Amelia and Owen (Kevin McKidd). "They are officially on the books 'friends' at this point but they are certainly not buddies [though] their pheromones would maybe disagree with their official relationship status," she says with a laugh. "She deserves a little bit of happy. With Ryan and Derek, she's had her fair share of tragic male loss [including her father]. Owen is fundamentally different than anyone Amelia has encountered before. He's out of the wheelhouse that she's comfortable with; he's an adult. He can equal her in tragedy and loss and yet he's persevering in the way that she is. There's a level of respect that she is surprised by. She definitely sees him as a person of substance."

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Grey's Anatomy season 12 premieres Thursday, Sept. 24 at 8 p.m. on ABC. What are you looking forward to seeing? Sound off in the comments section, below.

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