Treating digestive and gastrointestinal issues in patients with ASD is the mainstay of a good biomedical approach. Even with traditional tools in place, such as using special diets, probiotics, enzymes, antimicrobials, and anti-inflammatories, many patients are still plagued with chronic GI complaints. Newer, research points to the role that intestinal biofilms play in chronic infections and to the effectiveness of symbiotics, enzymatic degradation, and disodium EDTA in normalizing gut health. In addition, various innovative strategies have been implemented by parents in our practice to further aid gut recovery.