Individuals with moderate-to-severe plaque psoriasis may reap better long-term improvements in the severity of their condition when treated with guselkumab over secukinumab, according to findings of the phase III ECLIPSE* trial presented at the recent Inflammatory Skin Disease Summit (ISDS 2018) held in Vienna, Austria.

Use of standard-dose aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs) appears to confer protection against the risk of endometrial cancer in overweight and obese women, according to a meta-analysis.

Discontinuing the use of tyrosine kinase inhibitors (TKIs) in the treatment of patients with chronic myeloid leukaemia appears to be feasible in real-life clinical practice in the context of close molecular monitoring, a study reports.

Substituting diets high in carbohydrates with those high in monounsaturated fatty acids (MUFAs) in the context of low saturated fatty acids do not appear to yield favourable effects on blood pressure, according to a meta-analysis.

Researchers conducted a systematic review of randomized controlled trials evaluating the effect of a >3-week intervention of high-MUFA diets in isocaloric substitution for high-carbohydrate diets on systolic blood pressure (SBP) and diastolic blood pressure (DBP). A total of 14 trials representing 980 participants were included in the meta-analysis.

Visual inspection of funnel plots revealed no evidence of a publication bias. This was confirmed by Egger’s and Begg’s tests, which showed no significant small-study effects for either SBP or DBP. The overall quality of the evidence was assessed as moderate.

According to researchers, the analysis may be considered surprising, given that current dietary cardiovascular disease recommendations indicate a 1-unit reduction in SBP in adults with BP ranging 120–159/80–95 mm Hg after replacing 10 percent of energy intake from carbohydrates with MUFA.

Individuals with moderate-to-severe plaque psoriasis may reap better long-term improvements in the severity of their condition when treated with guselkumab over secukinumab, according to findings of the phase III ECLIPSE* trial presented at the recent Inflammatory Skin Disease Summit (ISDS 2018) held in Vienna, Austria.

Use of standard-dose aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs) appears to confer protection against the risk of endometrial cancer in overweight and obese women, according to a meta-analysis.

Discontinuing the use of tyrosine kinase inhibitors (TKIs) in the treatment of patients with chronic myeloid leukaemia appears to be feasible in real-life clinical practice in the context of close molecular monitoring, a study reports.