Yes, you can update the cells in multiple selected rows. You
gave an small information to provide solution or suggestion. But using this, I am
unable to understand what kind of request / response you want. But in general ,
you can use the currentcellstartediting or CurrentCellEditingCompleted events
to update the values while editing the same cells. Please use these events to
update the cell value in your apps .

Please provide the sample with replication procedure if you
need more information regarding this.