It is well understood that many proteins within the cell undergo specific and targeted subcellular localization. Various stimuli can impact the targeting of these proteins, allowing the cell to exact physiological responses in a rapid and efficient manner. One exemplary class of proteins undergoing subcellular targeting are RNA-binding proteins (RBPs), which bind RNAs to affect their function and fate. Each hexagonal panel shows a differentially localized RBP in response to DNA damage, a major hallmark of cancer. The layout as shown is a classic sewing pattern for a ball, and each panel, like our understanding of separate RBPs, needs to be folded and stitched together to create a 3-dimensional composite whole. The grey pentagons represent the black boxes of this story, information we have yet to uncover.