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COASY Antigen Profile

Antigen Summary

Biosynthesis of coenzyme A (CoA) from pantothenic acid (vitamin B5) is an essential universal pathway in prokaryotes and eukaryotes. COASY is a bifunctional enzyme that catalyzes the 2 last steps in CoA synthesis. These activities are performed by 2 separate enzymes, phosphopantetheine adenylyltransferase (PPAT\; EC 2.7.7.3) and dephospho-CoA kinase (DPCK\; EC 2.7.1.24), in prokaryotes (Daugherty et al., 2002