The
present study examined the effects of sleep fragmentation (SF) in the
hippocampus and the cortex of mice using proton MR spectroscopy at 14.1T.
Disruptions in brain sensory processing and cognitive performance were seen
during sleep fragmentation. Moreover, there is evidence that SF negatively affects
memory and learning. Here, significant decreases in GABA and Lactate
concentrations were detected in the hippocampus of mice following sleep
fragmentation indicating decreased synaptic function in the hippocampus.