Close0000-0003-3194-0030Epidemiology, Biostatistics and Biodemography, Department of Public Health, Faculty of Health Sciences, SDU

DOI:

10.1038/hr.2012.90

Abstract:

Elevated pulse pressure (PP) is associated with cardiovascular disorders and mortality in various populations. The genetic influence on PP has been confirmed by heritability estimates using related individuals. Recently, efforts have been made by mapping genes that are linked to the phenotype. We report the results of our gene mapping studies conducted in the Chinese population in mainland China. The genome-wide linkage and association scans were carried out on 63 middle-aged dizygotic twin pairs using high-density markers. The linkage analysis identified three significant linkage peaks (all with a single point P