Marta M GagliaNeuroscience Graduate Program and Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California, USAPLoS Genet 8:e1003133. 2012

..elegans. This situation is reminiscent of the complex regulation of physiology by the mammalian hypothalamus, which also receives innervations from sensory systems, most notably the visual and olfactory systems...

David CristinaDepartment of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California, United States of AmericaPLoS Genet 5:e1000450. 2009

..Loss of fstr-1/2 does not suppress the phenotypes of all long-lived mitochondrial mutants. Thus, although different mitochondrial perturbations activate similar transcriptional and physiological responses, they do so in different ways...

A transcription elongation factor that links signals from the reproductive system to lifespan extension in Caenorhabditis elegans

Arjumand GhaziDepartment of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California, United States of AmericaPLoS Genet 5:e1000639. 2009

Cynthia J KenyonDepartment of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California 94158, USANature 464:504-12. 2010

..Which genes can extend lifespan? Can we augment their activities and live even longer? After centuries of wistful poetry and wild imagination, we are now getting answers, often unexpected ones, to these fundamental questions...

..Overexpression of PTP-3A is able to bypass the requirement for nid-1 for the localization of SYD-2 and RIM. We propose that PTP-3A acts as a molecular link between the extracellular matrix and alpha-liprin during synaptogenesis...

Research Grants37

..Understanding this pathway in detail will ultimately answer the two most important questions in the aging field: how the aging process itself takes place, and how it can be regulated by endocrine signaling. ..

..Understanding this pathway in detail will ultimately answer the two most important questions in the aging field: how the aging process itself takes place, and how it can be regulated by endocrine signaling. ..

..Understanding this pathway in detail will ultimately answer the two most important questions in the aging field: how the aging process itself takes place, and how it can be regulated by endocrine signaling. ..

..Understanding this pathway in detail will ultimately answer the two most important questions in the aging field: how the aging process itself takes place, and how it can be regulated by endocrine signaling. ..

..Understanding this pathway in detail will ultimately answer the two most important questions in the aging field: how the aging process itself takes place, and how it can be regulated by endocrine signaling. ..