On 16 April 1956, the South Dakota Air National Guard175th Fighter-Interceptor Squadron was authorized to expand to a group level, and the 114th Fighter-Interceptor Group was established by the National Guard Bureau. The 175th FIS becoming the group's flying squadron. Other squadrons assigned into the group were the 114th Headquarters, 114th Material Squadron (Maintenance), 114th Combat Support Squadron, and the 114th USAF Dispensary.

During the 1950s and 1960s, the unit was upgraded by ADC as newer interceptors became available to the Air National Guard. F-89 Scorpions were received in 1958 and F-102A Delta Dagger supersonic aircraft in 1960.

News was received in March 1976 of the replacement of the unit's F-100D aircraft with A-7D Corsair II jets. The last Super Sabres left Joe Foss Field in June 1977. In 1979, the unit began a 12-year era of participation in Operation Coronet Cove at Howard AFB providing for defense of the Panama Canal. Both aircrew and support personnel were extended there in the summer of 1979 during the Nicaraguan crisis. The unit was awarded the Armed Forces Expeditionary Streamer for combat duty as a part of Operation Just Cause during 1989-1990.

Tactical Air Command began retiring the A-7D in the late 1980s, with units being transitioned from the A-7D/K to the F-16C/D block 30. The first F-16 to arrive with the 175th Fighter Squadron was on 14 August 1991. In June 1993 the squadron deployed eight aircraft to Brustem AB, Belgium as Coronet DART for the European exercise Central Enterprise 1993. In December 1993 the squadron deployed again, this time for their first combat deployment with the F-16. Stationed at Incirlik AB, Turkey the squadron flew missions over Northern Iraq to guard the no-fly zone to protect Kurdish refugees.

Combat patrol missions were flown over the northern "No Fly" zone of Iraq from December 1993 to January 1994. The 114th Fighter Group was re-designated as the 114th Fighter Wing in October 1995. The unit subsequently supported Operation Northern Watch, based out of Turkey in 1995 and 2002, and Operation Southern Watch based out of Kuwait in 1998 and Saudi Arabia in 2001. The Fighting Lobos were also deployed to Belgium, Singapore, the Netherlands Antilles and Israel.

A new chapter was opened in the history of the Air National Guard with the terrorist attacks on America on September 11, 2001. In addition to the unit's ongoing tasking as part of the Air Expeditionary Force (AEF), unit members were also activated to support Operation Noble Eagle within the United States and Operation Enduring Freedom (OIF). OIF deployments during the 2000s included three to Balad AB, Iraq (October–December 2006; June–September 2008; January–April 2010. Unit members also deployed to the United Arab Emirates, Qatar, Oman, Kuwait, Saudi Arabia, Iraq, Jordan, Cyprus, Pakistan, Romania, Bosnia-Herzegovina, Turkey, Spain, France and Germany.

On 25 October 2005 an F-16 of the unit was attempting to take fuel from a KC-10 Extender. The jet suffered more than $930,000 of damage. The boom operator's accidental oscillation caused damages to both aircraft which were able to land safely. An unusual accident for a squadron which has enjoyed a tremendous safety record. During 2007 the squadron was the recipient of the National Guard Bureau’s Winston P. Wilson Trophy. The trophy goes to the most outstanding Air National Guard unit and is awarded annually. Just three years later the squadron would win the trophy again in 2010.

The 2005 Base Realignment and Closure committee recommended that the 175th Fighter Squadron retire its older block 30 F-16s and upgrade to the block 40. The first F-16C block 30 to depart was 'Cujo' aircraft (#85-1434) which occurred on 7 May 2010 with destination AMARG. Over the next five months they received block 40 vipers from all three squadrons at Hill AFB, Utah which were largely as a result of the closure of the 34th Fighter Squadron.