Purpose: The objective of this study is to introduce a model for factors affecting organizational architecture in Islamic Azad University. Methodology: This is an applied research in terms of objective, and a descriptive research in terms of collecting data. In addition, according to the objective and nature of the research, this is an exploratory research. The statistical population consists of all faculty members working in Islamic Azad University; i.e.31000 members. Based on cluster sampling method and Morgan table, the sample must include 379 members; however, for prevention of probable loss, we finally selected 500 members. Data is collected through interviews and a questionnaire. The validity of the research instrument is confirmed by content validity. The reliability is measured based on Cronbach's alpha coefficient. Findings: The findings define factors affecting organizational architecture as: educational and research factor, organizational support and participation factor, physical factor, size of organization, and psychological factor. Discussion: A model is introduced considering the mentioned factors, which is well fitted. According to the model, factors affecting organizational architecture in Islamic Azad University are in a good current status; however, there is a difference between the current and the desirable status of factors influencing organizational architecture in Islamic Azad University.