Form 8.3 - ABBVIE INC

A PERSON WITH INTERESTS IN RELEVANT SECURITIES REPRESENTING 1% OR MORE

Rule 8.3 of the Takeover Code (the “Code”)

1. KEY INFORMATION

(a) Identity of the person whose positions/dealings are being
disclosed:

Barclays PLC.

(b) Owner or controller of interests and short positions disclosed,
if different from 1(a):

The naming of nominee or vehicle companies is insufficient

(c) Name of offeror/offeree in relation to whose relevant securities
this form relates:

Use a separate form for each offeror/offeree

ABBVIE INC

(d) If an exempt fund manager connected with an offeror/offeree,
state this and specify identity of offeror/offeree:

(e) Date position held/dealing undertaken:

20 Oct 2014

(f) Has the discloser previously disclosed, or are they today
disclosing, under the Code in respect of any other party to this
offer?

YES:

SHIRE PLC

2. POSITIONS OF THE PERSON MAKING THE DISCLOSURE

(a) Interests and short positions in the relevant securities of the
offeror or offeree to which the disclosure relates following the dealing
(if any)

Class of relevant security:

ORD

Interests

Short Positions

Number

(%)

Number

(%)

(1)

Relevant securities owned

and/or controlled:

5,661,698

0.36%

708,685

0.04%

(2)

Derivatives (other than

options):

0

0.00%

0

0.00%

(3)

Options and agreements to

purchase/sell:

6,643,718

0.42%

9,746,200

0.61%

(4)

TOTAL:

12,305,416

0.77%

10,454,885

0.66%

All interests and all short positions should be disclosed.

Details of any open derivative or option positions, or agreements to
purchase or sell relevant securities, should be given on a Supplemental
Form 8 (Open Positions).

(b) Rights to subscribe for new securities (including directors’ and
other executive options)

Class of relevant security in relation to which subscription right
exists:

Details, including nature of the rights concerned and relevant
percentages:

If there are positions or rights to subscribe to disclose in more than
one class of relevant securities of the offeror or offeree named in
1(c), copy table 2(a) or (b) (as appropriate) for each additional class
of relevant security.

3. DEALINGS (IF ANY) BY THE PERSON MAKING THE DISCLOSURE

(a) Purchases and sales

Class of relevant

Purchase/sale

Number of

Price per unit

security

securities

ORD

Purchase

4

53.6200 USD

ORD

Purchase

50

54.2700 USD

ORD

Purchase

58

54.4900 USD

ORD

Purchase

100

53.6100 USD

ORD

Purchase

100

53.6600 USD

ORD

Purchase

114

53.2500 USD

ORD

Purchase

115

53.6673 USD

ORD

Purchase

180

54.4300 USD

ORD

Purchase

200

54.3900 USD

ORD

Purchase

200

54.4700 USD

ORD

Purchase

200

54.5000 USD

ORD

Purchase

230

53.7039 USD

ORD

Purchase

272

53.4600 USD

ORD

Purchase

298

53.9984 USD

ORD

Purchase

300

53.6533 USD

ORD

Purchase

300

53.9303 USD

ORD

Purchase

300

53.9703 USD

ORD

Purchase

300

54.4600 USD

ORD

Purchase

310

53.9983 USD

ORD

Purchase

400

54.4562 USD

ORD

Purchase

500

53.4679 USD

ORD

Purchase

500

53.6700 USD

ORD

Purchase

500

54.4620 USD

ORD

Purchase

683

54.1800 USD

ORD

Purchase

800

54.4405 USD

ORD

Purchase

800

54.4425 USD

ORD

Purchase

800

54.4556 USD

ORD

Purchase

888

53.8475 USD

ORD

Purchase

900

54.4755 USD

ORD

Purchase

1,041

53.8133 USD

ORD

Purchase

1,100

53.6445 USD

ORD

Purchase

1,200

53.6300 USD

ORD

Purchase

1,200

53.6358 USD

ORD

Purchase

1,311

53.7813 USD

ORD

Purchase

1,500

53.9570 USD

ORD

Purchase

1,545

53.8138 USD

ORD

Purchase

1,709

53.7117 USD

ORD

Purchase

1,900

53.6400 USD

ORD

Purchase

2,000

53.6020 USD

ORD

Purchase

2,000

54.4447 USD

ORD

Purchase

2,023

54.1715 USD

ORD

Purchase

2,100

54.4500 USD

ORD

Purchase

2,200

53.4877 USD

ORD

Purchase

2,905

53.6551 USD

ORD

Purchase

3,279

53.7089 USD

ORD

Purchase

3,286

53.8700 USD

ORD

Purchase

3,483

53.6414 USD

ORD

Purchase

3,510

53.9491 USD

ORD

Purchase

3,900

54.4518 USD

ORD

Purchase

4,013

53.6391 USD

ORD

Purchase

4,078

53.8991 USD

ORD

Purchase

4,508

53.6720 USD

ORD

Purchase

5,124

53.6375 USD

ORD

Purchase

5,168

54.2297 USD

ORD

Purchase

6,002

54.1155 USD

ORD

Purchase

7,108

53.7828 USD

ORD

Purchase

8,500

54.4142 USD

ORD

Purchase

8,546

54.4519 USD

ORD

Purchase

8,697

54.0497 USD

ORD

Purchase

8,877

53.8280 USD

ORD

Purchase

10,236

53.6465 USD

ORD

Purchase

11,200

54.3998 USD

ORD

Purchase

11,560

53.6081 USD

ORD

Purchase

11,702

53.7061 USD

ORD

Purchase

11,900

53.9055 USD

ORD

Purchase

12,174

54.4621 USD

ORD

Purchase

12,378

53.3700 USD

ORD

Purchase

12,737

53.9772 USD

ORD

Purchase

15,580

53.8985 USD

ORD

Purchase

19,818

53.6990 USD

ORD

Purchase

22,500

54.0950 USD

ORD

Purchase

25,050

52.5417 USD

ORD

Purchase

25,700

53.7268 USD

ORD

Purchase

39,900

53.9200 USD

ORD

Purchase

40,889

53.9929 USD

ORD

Purchase

43,608

54.0393 USD

ORD

Purchase

44,714

53.6996 USD

ORD

Purchase

52,370

53.9546 USD

ORD

Purchase

80,640

53.7308 USD

ORD

Purchase

96,531

54.3371 USD

ORD

Purchase

144,665

54.0300 USD

ORD

Purchase

1,186,716

54.4100 USD

ORD

Sale

25

53.9100 USD

ORD

Sale

30

54.4150 USD

ORD

Sale

50

54.2700 USD

ORD

Sale

51

53.0100 USD

ORD

Sale

58

54.4900 USD

ORD

Sale

71

54.3700 USD

ORD

Sale

90

53.6000 USD

ORD

Sale

100

53.2700 USD

ORD

Sale

100

53.4110 USD

ORD

Sale

100

53.9500 USD

ORD

Sale

100

53.9600 USD

ORD

Sale

100

54.0072 USD

ORD

Sale

100

54.2500 USD

ORD

Sale

100

54.4000 USD

ORD

Sale

100

54.4050 USD

ORD

Sale

100

54.4950 USD

ORD

Sale

153

53.0300 USD

ORD

Sale

176

53.3304 USD

ORD

Sale

200

53.9550 USD

ORD

Sale

200

53.9575 USD

ORD

Sale

200

54.4500 USD

ORD

Sale

223

54.4463 USD

ORD

Sale

300

53.9533 USD

ORD

Sale

300

54.1600 USD

ORD

Sale

304

53.9983 USD

ORD

Sale

383

54.2008 USD

ORD

Sale

500

53.6480 USD

ORD

Sale

500

54.1660 USD

ORD

Sale

500

54.4120 USD

ORD

Sale

504

54.0823 USD

ORD

Sale

565

53.8223 USD

ORD

Sale

661

54.2509 USD

ORD

Sale

683

54.1800 USD

ORD

Sale

700

54.4485 USD

ORD

Sale

900

54.1105 USD

ORD

Sale

1,000

53.6301 USD

ORD

Sale

1,000

54.4330 USD

ORD

Sale

1,400

54.4342 USD

ORD

Sale

1,534

54.2247 USD

ORD

Sale

1,700

54.0759 USD

ORD

Sale

2,200

53.4877 USD

ORD

Sale

2,458

54.3825 USD

ORD

Sale

2,485

53.5100 USD

ORD

Sale

2,495

54.1351 USD

ORD

Sale

2,632

54.2098 USD

ORD

Sale

2,677

54.3823 USD

ORD

Sale

3,015

54.3643 USD

ORD

Sale

3,407

54.0369 USD

ORD

Sale

3,700

54.1470 USD

ORD

Sale

3,857

54.1867 USD

ORD

Sale

4,455

54.1765 USD

ORD

Sale

7,500

54.0187 USD

ORD

Sale

7,658

54.3938 USD

ORD

Sale

9,122

54.0260 USD

ORD

Sale

9,494

54.0897 USD

ORD

Sale

12,378

53.3700 USD

ORD

Sale

13,500

53.8705 USD

ORD

Sale

15,900

54.0739 USD

ORD

Sale

16,000

53.7780 USD

ORD

Sale

19,156

54.3768 USD

ORD

Sale

20,200

54.0940 USD

ORD

Sale

21,950

53.6305 USD

ORD

Sale

25,000

52.5400 USD

ORD

Sale

29,758

54.2288 USD

ORD

Sale

31,459

54.4177 USD

ORD

Sale

64,022

54.0392 USD

ORD

Sale

80,640

53.7308 USD

ORD

Sale

80,840

53.7321 USD

ORD

Sale

142,386

54.0154 USD

ORD

Sale

173,848

53.8890 USD

ORD

Sale

1,194,076

54.4100 USD

(b) Derivatives transactions (other than options)

Class of relevant security

Product description

e.g. CFD

Nature of dealing

e.g. opening/closing a long/short position, increasing/reducing a
long/short position

Number of reference securities

Price per unit

(c) Options transactions in respect of existing securities

(i) Writing, selling, purchasing or varying

Class

Product

Writing,

Number

Exercise

Type

Expiry

Option

of

description

purchasing,

of

price

date

money

relevant

selling,

securities

per unit

paid/

security

varying etc

to which

received

option

per unit

relates

ORD

Call Options

Purchasing

200

62.5 USD

American

17 Jan 2015

0.2500 USD

ORD

Call Options

Selling

300

55 USD

American

22 Nov 2014

1.3000 USD

ORD

Call Options

Selling

8,200

55 USD

American

20 Feb 2015

2.9000 USD

ORD

Put Options

Purchasing

20,000

52.5 USD

American

22 Nov 2014

1.6400 USD

ORD

Put Options

Purchasing

20,000

57.5 USD

American

22 Nov 2014

4.3392 USD

ORD

Put Options

Selling

2,700

50 USD

American

22 Nov 2014

0.8240 USD

ORD

Put Options

Selling

20,000

52.5 USD

American

22 Nov 2014

1.4992 USD

ORD

Put Options

Selling

100

52.5 USD

American

22 Nov 2014

1.5000 USD

ORD

Put Options

Selling

20,000

57.5 USD

American

22 Nov 2014

4.4888 USD

(ii) Exercising

Class of relevant security

Product description

e.g. call option

Number of securities

Exercise price per unit

(d) Other dealings (including subscribing for new securities)

Class of relevant security

Nature of dealing

e.g. subscription, conversion

Details

Price per unit (if applicable)

The currency of all prices and other monetary amounts should be stated.

Where there have been dealings in more than one class of relevant
securities of the offeror or offeree named in 1(c), copy table 3(a),
(b), (c) or (d) (as appropriate) for each additional class of relevant
security dealt in.

4. OTHER INFORMATION

(a) Indemnity and other dealing arrangements

Details of any indemnity or option arrangement, or any agreement or
understanding, formal or informal, relating to relevant securities
which may be an inducement to deal or refrain from dealing entered
into by the person making the disclosure and any party to the offer
or any person acting in concert with a party to the offer:

If there are no such agreements, arrangements or understandings,
state “none”

NONE

(b) Agreements, arrangements or understandings relating to options or
derivatives

Details of any agreement, arrangement or understanding, formal or
informal, between the person making the disclosure and any other
person relating to:

(i) the voting rights of any relevant securities under any option;
or

(ii) the voting rights or future acquisition or disposal of any
relevant securities to which any derivative is referenced:

If there are no such agreements, arrangements or understandings,
state “none”

NONE

(c) Attachments

Is a Supplemental Form 8 (Open Positions) attached?

YES

Date of disclosure:

21 Oct 2014

Contact name:

Rajesh Muthanna

Telephone number:

020 3555 4634

Public disclosures under Rule 8 of the Code must be made to a Regulatory
Information Service and must also be emailed to the Takeover Panel at
monitoring@disclosure.org.uk. The Panel’s Market Surveillance Unit is
available for consultation in relation to the Code’s dealing disclosure
requirements on +44 (0)20 7638 0129.