Endothelin receptor type B (EDNRB) belongs to the guanine
nucleotide binding protein (G-protein) coupled receptor family.
Endothelin-1 is most investigated physiological ligand of
EDNRB [1]. EDNRB
binds to many types of the G-proteins but the main physiological consequence is exerted
via its binding to the G-protein alpha-q/11 and
G-protein alpha-i family subunits [2], [3], [4].

Scaffolding Caveolin 1, caveolae protein, 22kDa
(Caveolin-1) interacts with
EDNRB. EDNRB bound
to Caveolin-1 is targeted to caveolae. Upon
Endothelin-1 stimulation, EDNRB
dissociates from Caveolin-1 and exits from the caveolae.
Caveolae localization of EDNRB is one of the mechanisms to
ensure the balance of EDNRB-mediated signal transduction
[5].

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