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The Modern Approach to Modes of Mechanical Ventilation

While modes have classically been divided up into pressure or volume controlled modes, a more modern approach describes ventilatory modes based on three characteristics – the slippers Bathroom 43 Bathroom 43 slippers trigger (flow versus pressure), thelimit (what determines the size of the breath), and the cycle (what actually ends the breath). In both VCV and PCV, time is the cycle, the difference being in how the time to cessation is determined. PSV, by contrast, has a flow cycle.

Note also that the lines between pressure and volume controlled methods are being continually blurred by increasingly complex modes. If alarms and backup modes are properly set, the “disadvantages” of classic modes (e.g. possibility of insufficient minute ventilation in PCV) can be essentially eliminated

43 Bathroom Bathroom slippers 43 slippers For historical reasons, the following modes will be separated into volume controlled, pressure controlled, and other modes

Also known as continuous mandatory ventilation (CMV). Each breath is either an assist or control breath, but they are all of the same volume. The larger the volume, the more expiratory time required. If the I:E ratio is less than 1:2, progressive hyperinflation may result. ACV is particularly undesirable for patients who breathe rapidly – they may induce both hyperinflation and respiratory alkalosis. Note that mechanical ventilation does not eliminate the work of breathing, because the diaphragm may still be very active.

Bathroom slippers 43 Bathroom slippers 43 Guarantees a certain number of breaths, but unlike ACV, patient breaths are partially their own, reducing the risk of hyperinflation or alkalosis. Mandatory breaths are synchronized to coincide with spontaneous respirations. Disadvantages of SIMV are increased work of breathing and a tendency to reduce cardiac output, which may prolong ventilator dependency. The addition of pressure support on top of spontaneous breaths can reduce some of the work of breathing. SIMV has been shown to decrease cardiac output in patients with left-ventricular dysfunction [Crit Care Med 10: 423, 1982]

ACV vs. SIMV

Personal preference prevails, except in the following scenarios: 1. Patients who breathe rapidly on ACV should switch to SIMV 2. Patients who have respiratory muscle weakness and/or left-ventricular dysfunction should be switched to ACV

Pressure-Controlled Ventilation (PCV)

Less risk of barotrauma as compared to ACV and SIMV. Does not allow for patient-initiated breaths. The inspiratory flow pattern decreases exponentially, reducing peak pressures and improving gas exchange [Chest 122: 2096, 2002]. The major disadvantage is that there are no guarantees for volume, especially when lung mechanics are changing. Thus, PCV has traditionally been preferred for patients with neuromuscular disease but otherwise normal lungs

Pressure Support Ventilation (PSV)

Allows the patient to determine inflation volume and respiratory frequency (but not pressure, as this is pressure-controlled), thus can only be used to augment spontaneous breathing. Pressure support can be used to overcome the resistance of ventilator tubing in another cycle (5 – 10 cm H20 are generally used, especially during weaning), or to augment spontaneous breathing. PSV can be delivered through specialized face masks.

Pressure Controlled Inverse Ratio Ventilation (PCIRV)

Pressure controlled ventilatory mode in which the majority of time is spent at the higher (inspiratory) pressure. Early trials were promising, however the risks of auto PEEP and hemodynamic deterioration due to the decreased expiratory time and increased mean airway pressure generally outweight the small potential for improved oxygenation

Airway Pressure Release Ventilation (APRV)

Airway pressure release ventilation is similar to PCIRV – instead of being a variation of PCV in which the I:E ratio is reversed, APRV is a variation of CPAP that releases pressure temporarily on exhalation. This unique mode of ventilation results in higher average airway pressures. Patients are able to spontaneously ventilate at both low and high pressures, although typically most (or all) ventilation occurs at the high pressure. In the absence of attempted breaths, APRV and PCIRV are identical. As in PCIRV, hemodynamic compromise is a concern in APRV. Additionally, APRV typically requires increased sedation

Dual Modes

Pressure Regulated Volume Control (PRVC)

A volume target backup is added to a pressure assist-control mode

Interactive Modes

Proportional Assist Ventilation (PAV)

During PAV, the clinician sets the percentage of work of breathing to be provided by the ventilator. PAV uses a positive feedback loop to accomplish this, which requires knowledge of resistance and elastance to properly attenuate the signal

Compliance and resistance must therefore be periodically calculated – this is accomplished by usingintermittent end-inspiratory and end-expiratory pause maneuvers (which also calculate auto PEEP). In addition to percent support, the clinician sets the trigger and the cycle (what actually ends the breath)

Bathroom Bathroom slippers slippers 43 43 The theoretical advantage of PAV is increased synchrony compared to PSV (which provides the same amount of support regardless of how much effort the patient makes)

Proportional Assist Ventilation: Summary

Independent Variables: % WOB; trigger; cycle

How It Works: positive feedback loop (requires calcluation of resistance and elastance)

Addtional Modes, Strategies, Parameters

Inverse Ratio Ventilation

Inverse Ratio Ventilation (IRV) is a subset of PCV in which inflation time is prolonged (In IRV, 1:1, 2:1, or 3:1 may be use. Normal I:E is 1:3). This lowers peak airway pressures but increases mean airway pressures. The result may be improved oxygenation but at the expense of compromised venous return and cardiac output, thus it is not clear that this mode of ventilation leads to improved survival. IRV’s major indication is in patients with ARDS with refractory hypoxemia or hypercapnia in other modes of ventilation [Am J Surg 183: 151, 2002]

Adaptive Support Ventilation

Calculates the expiratory time constant in order to guarantee sufficient expiratory time and thus minimize air trapping

Tube Compensation

Does not allow alveolar pressure to equilibrate with the atmosphere. PEEP displaces the entire pressure waveform, thus mean intrathoracic pressure increases and the effects on cardiac output are amplified. Low levels of PEEP can be very dangerous, even 5 cm H20, especially in patients with hypovolemia or cardiac dysfunction. When measuring the effectiveness of PEEP, cardiac output must always be calculated because at high saturations, changes in Q will be more important than SaO2 – never use SaO2 as an endpoint for PEEP. The effects of PEEP are not caused by the PEEP itself but by its effects on Ppeak and Pmean, both of which it increases. Risk of barotrauma is dependent on Ppeak, while cardiac output response depends on Pmean. In fact, in a recent study of ARDS patients, it was shown that increasing PEEP from 0 to 5, 10, and 15 cm H2O was met with corresponding decreases in CO [Crit Care Med 31: 2719, 2003]

slippers 43 Bathroom Bathroom 43 slippers PEEP is indicated clinically for 1) low-volume ventilation cycles 2) FiO2 requirements > 0.60, especially in stiff, diffusely injured lungs such as ARDS and 3) obstructive lung disease. Do NOT use in pneumonia, which is not diffuse, and where PEEP will adversely affect healthy tissue and worsen oxygenation. One way to gauge the effect of PEEP is to look at peak inspiratory pressure (PIP) – if PIP increases less than the added PEEP, then the PEEP improved the compliance of the lungs.

A recent phenomena in the understanding of PEEP is the principle of recruitable lung volume: while this cannot be calculated, it can be estimated by looking at CT scans: atalectasis containing air is recruitable, that devoid of air is not, the idea being only apply PEEP to recruitable lungs, otherwise you may just be inducing ARDS [NEJM 354: 1775, 2006]. The effects of PEEP can also be monitored by tracking the PaO2/FiO2 ratio (it should increase).

ARDSnet II: 8.3 vs. 13.2 cm H2O: in patients with acute lung injury and ARDS who receive mechanical ventilation with a tidal-volume goal of 6 ml per kilogram of predicted body weight and an end-inspiratory plateau-pressure limit of 30 cm of water, clinical outcomes are similar whether lower or higher PEEP levels are used [NEJM 351: 327, 2004]

PEEP should not be used routinely. It does not reduce lung edema (can cause it) or prevent mediastinal bleeding.

Continuous Positive Airway Pressure (CPAP)

Positive pressure given throughout the cycle. It can be delivered through a mask and is can be used in obstructive sleep apnea (esp. with a nasal mask), to postpone intubation, or to treat acute exacerbations of COPD