Archive for Category: General

When we are young, our blood #stem cells produce an even and well-balanced number of red and white blood cells according to need. As we age, however, the capacity of the blood stem cells to produce the number of blood cells we need declines. Like it or not, your body gradually loses its capacity for producing blood as you age — that’s why immune deficiencies, leukemia and other blood conditions become more likely with time. Scientists may have found a way to turn back the clock, though. They’ve...

Most clinicians know that cerebral #malaria, a complication associated with the all-too-common mosquito-borne virus that affects much of the developing world, can be deadly; however, relatively little is known about exactly how the disease attacks the human #brain.
That may be changing. Using mouse models the authors of a study demonstrated that cytotoxic #T-cells attack cerebral blood vessels leading to swelling in the brain. They believe that their findings mirror how cerebral malaria affects...

Human-induced pluripotent stem cells (iPS) possess an intrinsic tumor tropism ability. However, #iPS cells are impeded in clinical applications of tumor therapy due to the formation of teratomas and their survival in normal organs such as the liver, lungs, spleen and kidneys. #Mitomycin C (MMC) can overcome this limitation by suppressing iPS proliferation. Herein, we fabricated a safe delivery system of iPS cells treated with MMC loading with gold nanorods (AuNRs) for the targeted photothermal treatment...

The Army is already using regenerative medicine to help wounded soldiers while #Duke University is researching it to help repair spinal cord injuries.
U.S. Army scientists, working with medical technology companies, have successfully tested and used products and techniques that have enabled Army surgeons to replace the severely burned skin of soldiers as well as transplant new hands and even faces.
At Duke University, researchers are studying zebra fish to learn how science and medicine might...

Cold chain logistics can determine success or failure for any biotech company shipping time and/or temperature-sensitive products, many of which have the potential to save lives. These include traditional solid #organs intended for transplantation into a recipient, and also a new and growing class of novel cellular therapies and engineered tissue products.
In the high-profile and promising personalized medicine arena, a circular process is used with cold chain logistics playing a critical part...

#Stem cells with characteristics of totipotency — capable of creating all the tissue types needed to build and sustain an embryo — have been created in mice by a California-led research team.
Researchers found that a #microRNA called miR-34a prevents totipotency. Pluripotent mouse cells deficient in that microRNA acquired signs of totipotency.
The feat makes it feasible to explore the molecular basis of totipotency, said the researchers in a study, that was led by Yong Jin Choi and Chao-Po...

#Platelet Endothelial Cell Adhesion Molecule 1 (PECAM-1) is a major component of the endothelial cell intercellular junction. Previous studies have shown that PECAM-1 homophilic interactions, mediated by amino-terminal immunoglobulin homology domain 1, contribute to maintenance of the vascular permeability barrier and to its re-establishment following inflammatory or thrombotic insult. PECAM-1 glycans account for ∼30% of its molecular mass, and the newly solved crystal structure of human PECAM-1...

President-elect Trump’s cabinet appointments are generating a great deal of attention and controversy. After eight years of Democrat rule, it would be foolish to expect otherwise.
One appointment, though, will have a profound impact on your health… and the health of your loved ones.
The “progressive approval” process for drugs
The first potential FDA chief appointee leaked by the Trump transition team is Jim O’Neill. Managing director of Peter Thiel’s Mithril Capital, O’Neill...

Many researchers now believe that misfolded proteins spread from cell to cell across the brain, corrupting normal proteins as they go, yet exactly how this propagation would happen remains unclear. At the Society for Neuroscience annual meeting scientists identified specific mechanisms that may be involved in the spread of pathological proteins in Parkinson’s and Alzheimer’s diseases. They argued that astrocytes transmit α-synuclein aggregates by cell-to-cell contact; for tau, they argued...

“If we can further enhance our understanding of how these oligodendrocyte precursor cells mature, then it may be possible to stimulate them to replace myelin in diseases like multiple sclerosis.”, says Pablo Paez, PhD, Assistant professor and research scientist , unters James Kelly Research Institute at University at Buffalo, US.
The Researchers at the University at Buffalo have identified a critical step in myelination after birth that has significance for treating...

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