SAMe (S-adenosylmethionine), a compound native to the body, is a critical component of many biochemical reactions, including those that affect brain biochemistry and joint health. Numerous studies have indicated that SAMe can help to temporarily alleviate minor joint discomfort resulting from overexertion or stress. In addition, because SAMe is also necessary for the synthesis of neurotransmitters, it plays an important role in mood support. NOW SAMe is enteric-coated, which makes it very well tolerated and protects it from degradation.

A landmark study funded by the National Institute of Mental Health revealed that the addition of S-adenosylmethionine or SAMe produces compelling results in people taking SSRIs, the majority of whom do not experience relief when taking the drug alone.

SAMe is a naturally occurring molecule found in all living cells; it supports a host of chemical functions necessary for normal brain activity.

SAMe acts by several distinct and independent mechanisms to target multiple sites of action in brain cells that are involved in producing depression.

In clinical trials, SAMe has been shown to be at least as effective as prescription antidepressants, but with far fewer side effects.

Because of its strong safety record, SAMe should be part of any regimen for brain health, particularly when depressive symptoms are present—and when prescription drugs alone don’t work.

SAMe has also been shown to confer enormous benefits to the brain, liver, and joints, halting and even reversing various degenerative conditions, from osteoarthritis and neurodegeneration to nonalcoholic fatty liver disease.

For easing the pain and inflammation of osteoarthritis, studies suggest that SAM-e may be as powerful as standard nonprescription drugs. In an Italian study of 734 patients with osteoarthritis of the hip, knee, spine, or hand, 1,200 mg of SAM-e per day was as effective as 750 mg of naproxen. And in a German survey of more than 20,000 patients taking SAM-e for osteoarthritis, 71 percent reported "very good" or "good" improvement in joint discomfort. The Arthritis Foundation recently endorsed SAM-e as an effective pain reliever, although it doesn't support the claim that it contributes to "joint health." The organization also recommends taking supplemental B vitamins (800 mg of folic acid and 1,000 mg of B12 a day) to help your body get the most benefit from SAM-e.

Harvard researchers reviewed studies done to date and found that SAM-e was as effective as prescription antidepressants in relieving depression.

SAMe replenishes glutathione in the liver, the body’s major detoxifier.

SAMe is involved in the production of the neurotransmitters epinephrine and melatonin. This is significant, because melatonin is needed for deep, quality sleep. Sleep loss is a common symptom of both chronic pain and depression, and can lead to struggles with both pain and depression, a common combination.

Nutrition Info

Serving Size 1 Tablet

Amount Per Serving

% Daily Value

Vitamin B-6 (as Pyridoxine HCl)

2 mg

100%

Folic Acid

200 mcg

50%

Vitamin B-12 (as Cyanocobalamin)

50 mcg

833%

SAMe (S-Adenosyl L-Methionine)

200 mg

†

(from 400 mg of S-Adenosyl-L-Methionine Disulfate Tosylate)

Details

Serving Size: 1 Tablet

Suggested Usage: As a dietary supplement, take 1 tablet 1 to 2 times daily, preferably on an empty stomach. Refrigeration recommended after opening.

SAMe FAQs

What is SAMe?

SAMe (S-adenosylmethionine or S-Adenosyl-L-Methionine) is a naturally occurring compound found in all human tissue and organs. It is a building block necessary for the production of many compounds produced by your body, and is used in over 35 different biochemical reactions. SAMe actually donates a part of itself to form these new compounds through a process called methylation, or transmethylation. SAMe is one of the few dietary supplements on the market today that combines the benefits of several nutrients into one, because the body uses the substances produced from SAMe for numerous body processes, including detoxification.

Are there any side effects associated with SAMe supplementation?

SAMe is a very safe dietary supplement. Minor side effects include nausea and gastrointestinal irritation, probably due to its sulfur content. But these were only noted at very high doses (1200-1600mg), and the symptoms diminished with continued use. Persons suffering from manic depression (bipolar disorder) should not take SAMe without prior consultation with their physician. If you experience any of these symptoms, it may not be the right supplement for you. The mineral Sulfur is not related to sulfa drugs or allergies related to sulfa drugs.

Why is the dosage information with SAMe supplements so confusing?

SAMe in its pure form as found in human cells has a very short life span and is rapidly metabolized into other necessary compounds as needed, which is good! However, this natural form does not allow for the production of a stable, effective dietary supplement. It took scientists years to come up with a way to stabilize SAMe so it could be manufactured as a dietary supplement. It was finally discovered that SAMe (S-Adenosyl-L-Methionine) must be manufactured in a stable salt form (for example, as S-Adenosyl-L-Methionine Disulfate Tosylate) to prevent rapid degradation. In this form, you will actually get 200mg of SAMe compounded in a stable form. However, only half of this 200mg is pure SAMe (S-Adenosyl-L-Methionine). Please note that this salt is not a significant source of sodium.

Are there size or color variations with your SAMe products, and should SAMe be refrigerated?

Because of the nature of SAMe, NOW takes special precautions when packaging this product. Extensive stability testing was performed in order to create this uniquely stabilized product. We bottle SAMe in amber glass bottles to keep light exposure to a minimum, and keep SAMe products refrigerated in our plant until shipping. It is not necessary to keep SAMe refrigerated after purchase, but it will extend the shelf life of the product. The bottle should be kept closed between uses, away from excessive heat and moisture.

Because SAMe is a natural product, there can be variations in color, usually ranging from white to pale yellow or tan. This is normal and does not affect the quality of the product. You may also notice a difference in tablet size between different potencies. SAMe is available in 100mg, 200mg, and 400mg enteric-coated tablets, all coming in different sizes

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