Brothers has grown away from its funky blues-club vibe of days past. Now it features three rooms: a restaurant/tavern, a wine bar that specializes in acoustic sounds, and the roomy Music Hall, which hosts rock, blues, jazz, and reggae acts.

You’ll see the big stars at this anchor of the Flats’ west bank, but also no shortage of upstart young comics and the best local talent. A move to the nearby Sugar Warehouse after 22 years in the Powerhouse only bolsters the iconic club’s reputation.