"You look at the material world and see objects and how you can use them. I look at the material world and see a fascinating hidden life which is within our control, if we can only understand how it works," ...

A group of researchers at the University of California, Berkeley have for the first time described the structure of the active site core of topoisomerase II alpha, an important target for anti-cancer drugs.

Researchers in Japan have developed a technique which allows them to control and target drug delivery to specific sites of the body at specific times, thus reducing side effects and improving treatment dramatically. ...

Molecules with potent bioactivity alone are not suitable for new medicines. They must behave well inside the body, being easily absorbed, yet metabolically stable, once circulating through the blood stream. ...

Despite its small size, the fluorine atom has had a vast impact on the pharmaceutical industry. More often than not, introducing fluorine to a drug molecule improves the drug's biological activity, earning ...

A trawl of the genome of the deadly bacterium Bacillus anthracis has revealed a clutch of targets for new drugs to combat an epidemic of anthrax or a biological weapons attack. The targets are all proteins that are found ...

Living subjects are very complex systems and, at the same time, stunningly robust and accommodative. The secret of success are their proteins which build up the cells of the organisms, act as cleaners, messengers, ...

Researchers from the University of Kentucky have designed and discovered a series of highly efficient enzymes that effectively metabolize cocaine. These high-activity cocaine-metabolizing enzymes could potentially prevent ...

Potential applications for organic molecules that can interact with light in unusual ways range from next-generation solar cells to light-activated anticancer drugs. One of the oldest families of these brightly ...

occupied not by stars and planets but substances that could become useful in everyday life  has concluded that scientists have synthesized barely one tenth of 1 percent of the potential medicines that ...

The search for new drug candidates for cancer treatment is laborious and time-consuming. Only a fraction of the promising chemical compounds identified completes the transition to the market. Herbert Waldmann ...

(PhysOrg.com) -- US scientists have synthesized a polymethine dye that can be used for fluorescence anisotropy imaging in the near-infrared (NIR) spectral range, making new in vivo applications of this technique ...

In an advance toward eliminating pockets of infection in the brain that help make HIV disease incurable, scientists report the development of new substances that first plug the biological vacuum cleaner that ...