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In his thirteenth and final body, Azmael deliberately regenerated past his limit, killing him and Mestor, who had been attempting to possess Azmael's body after his own was destroyed. (TV: The Twin Dilemma)

In a story related by the Valeyard, the thirteenth and final incarnation of the Doctor supposedly composed a set of scrolls which detailed his work to bypass the limit of twelve regenerations. The Valeyard's claim, however, was doubted by the Sixth Doctor. Indeed, the Doctor found what appeared to be his final incarnation on Etarho to have been the Valeyard masquerading as him. (AUDIO: Trial of the Valeyard)

Lake regenerated twice. Following his first regeneration, Lake, unaware of the limit of his regenerative ability, proceeded to test it by inflicting fatal injuries against his fellow Proto-Time Lords while convincing others to commit suicide. To that end, he was responsible for the deaths of Rindle, Wadi, Creek, Beck, Stream, all of whom were determined to possess a different number of regenerations. Rindle regenerated four times before their remaining regenerations were expended by Lake to power his ship. Ironically, Lake's last victim was his third and final incarnation, a girl who became known as Lily having lost her memory of her prior lives. Having witnessed Lake regenerate into Lily after mortally wounding him in anger for murdering her, River Song was forced to send Lily back in time so she would meet her fate. Tarn had regenerated at least ten times. (AUDIO: The Lady in the Lake)