In the revolt of the Titans against the gods of the Olympic, Atlas stormed the heavens and Zeus punished him for this deed by condemning him to forever bear the heavens upon his shoulders. Hence his name, which means "bearer" or "endurer".

To complete the eleventh of his twelve labors, Heracles had to obtain the golden apples of the Hesperides, and he asked Atlas for help. Heracles offered to bear Atlas's burden in his absence, when he went to retrieve the apples. Atlas agreed to perform the task readily enough, since he did not plan on ever bearing that burden again. When Atlas returned with the apples, Heracles requested him to assume the load for a moment, saying he needed to adjust the pad to ease the pressure on his shoulders. After Atlas bore the heavens again, Heracles walked off with the golden apples.

When Atlas refused to give shelter to Perseus, the latter changed Atlas into stone, using Medusa's head. On the place where Atlas stood, now lie Mount Atlas (north-western Africa). In art, Atlas is usually depicted as a man bearing a globe.