Alcohol & Depression. Alcohol in any form -- including beer and tequila -- is a depressant. Combined with prozac, (fluoxetine) you could have much more sedation or intoxication than you expect. Especially when used in large quantities, alcohol disrupts your sleep cycle and neuronal tone. People usually take Prozac (fluoxetine) for depression or anxiety. Disrupting your sleep & neurons can worsen these conditions.