Reducing Surface Effects during Fablsims Ionization

When compounds with high surface activity properties are present in a mixture, even as minor components, they have been shown to suppress the ioniz-ation of the major components during analysis by FAB/LSIMS-MS. Compounds such as surfactants possess these properties to such an extent that analysis by liquid phase inonization is unpredictable. Often the major component (of interest) is suppressed so much that it may not appear to be the major component at all. Planar chromatography has been shown to be an effective way of separating such suppressants from the analyte of interest.

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