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5 Syphilis was definitely present in the Americas before European contact, 54 and it may have been carried from the Americas to Europe by the returning crewmen from Christopher Columbus 's voyage to the Americas ; or it may have existed in Europe previously, but. "Vorläufiger Bericht über das Vorkommen von Spirochaeten in syphilitischen Krankheitsprodukten und bei Papillomen" Preliminary report on the occurrence of Spirochaetes in syphilitic chancres and papillomas. 2 In 2015, about.4 million people were infected with syphilis, 3 with 6 million new cases., it caused about 107,000 deaths, down from 202,000 in 1990. 5 Secondary Typical presentation of secondary syphilis with a rash on the palms of the hands Reddish papules and nodules over much of the body due to secondary syphilis Secondary syphilis occurs approximately four to ten weeks after the primary infection. Medicina oral, patologia oral y cirugia bucal. Centers for Disease Control and Prevention (CDC). "Origins of syphilis and management in the immunocompetent patient: facts and controversies". At en del husdyr har store yver, skyldes målrettet avl (kunstig selektion for at øge mælkeproduktionen og er altså ikke noget naturlig fænomen. Beslægtet, treponema pallidum er årsag til andre sygdomme hos mennesker, herunder frambøsi (underarten pertenue pinta (underarten carateum ) og endemisk syfilis (underarten endemicum ).