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Giant Killer

Harvesters are gigantic synthetic reaper creatures with the ability to fly. One of the first chances to encounter such an enemy is during the Priority: Tuchanka 1 (Extract Turian Survivors) mission. It's recommended to set the difficulty down to 'Narrative.'

You can get the Giant Killer Achievement / Trophy by killing the first Harvester you encounter in Priority: Tuchanka. Use the Scorpion pistol along with Armor reducing powers from your Squad Members to reduce its yellow Armor bar. When it is nearly depleted, keep covering it in the sticky Scorpion shots and they will detonate just as it tries to leave the area.