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Premarin uses: This medication is a female hormone and is usually given to women who no longer produce the amount of estrogen they produced before menopause. It is a very effective treatment for reducing a common menopause symptom (intense feelings of warmth and sweating known as hot flashes). If you need treatment only for vaginal menopause symptoms (e.g., vaginal dryness), products applied directly inside the vagina should be considered before medications that are taken by mouth, absorbed through the skin, or injected.Certain estrogen products may also be used to prevent bone loss (osteoporosis) in people at high risk who cannot take non-estrogen drugs. There are several other medications (e.g., raloxifene, bisphosphonates such as alendronate) that are safe and effective to prevent or treat bone loss. These medicines should be considered for use before estrogen treatment.Certain estrogen products may also be used to treat certain cancers in men and women (e.g., certain types of metastatic breast cancer, prostate cancer) and other conditions as determined by your doctor.How to use Conjugated Estrogens OralRead the Patient Information Leaflet provided by your pharmacist before you start using this medication and each time you get a refill. If you have any questions, consult your doctor or pharmacist.Take this medication by mouth as directed by your doctor. It may be taken with or without food. You may take it with food or immediately after a meal to prevent stomach upset.Take this medication regularly in order to get the most benefit from it. Remember to take it at the same time(s) each day as directed. Dosage is based on your medical condition and response to treatment. Follow your dosing schedule carefully.Inform your doctor if your condition does not improve or worsens.Conjugated Estrogens Oral is used to treat the following:Breast Cancer that has Spread to Another Part of the Body, Cancer of the Prostate Gland, Defective Internal Secretion of Ovaries, Primary Ovarian Failure, Low Estrogen After Operation to Remove Ovaries, Wasting of Tissues of the Vulva, "Change of Life" Signs, Vaginal Inflammation due to Loss of Hormone Stimulation, Post-Menopausal Osteoporosis PreventionConjugated Estrogens Oral may also be used to treat:Softening of the Bones Before Menopause