The recognition of plant pathogens activates local defense responses and triggers a long-lasting systemic acquired resistance
(SAR) response. Activation of SAR requires the hormone salicylic acid (SA), which induces SA-responsive gene expression. Recent
data link changes in gene expression to chromatin remodeling, such as histone modifications and histone replacement. Here,
we propose a model in which recruitment of chromatin-modifying complexes to SA-responsive loci controls their basal and SA-induced
expression. Basal repression of these loci requires the post-translational modifier SUMO (SMALL UBIQUITIN-LIKE MODIFIER).
This is of particular relevance because SUMO conjugation has been shown to control the activity, assembly and disassembly
of chromatin-modifying complexes to transcription complexes. Chromatin remodeling could be instrumental for priming of SA-responsive
loci to enable their enhanced reactivation upon subsequent pathogen attack.

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