Carboxylesterase type B, conserved site (IPR019819)

Short name:
Carboxylesterase_B_CS

Description

Higher eukaryotes have many distinct esterases. Among the different types are
those which act on carboxylic esters (EC:3.1.1). Carboxyl-esterases have
been classified into three categories (A, B and C) on the basis of
differential patterns of inhibition by organophosphates. The sequence of a
number of type-B carboxylesterases indicates [PMID: 3163407, PMID: 1862088, PMID: 8453375] that the majority are evolutionary related. As is the case for lipases and serine proteases, the catalytic apparatus of
esterases involves three residues (catalytic triad): a serine, a glutamate or
aspartate and a histidine.

As is the case for lipases and serine proteases, the catalytic apparatus of esterases involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine. This entry represents a well conserved site located in the N-terminal section, which contains a cysteine involved in a disulphide bond. Human esterase-D, also a type-B carboxylesterase, does not seem to be evolutionary related.