Plus d’anticorps contre CGRP partenaires d’interaction

PCT use among sepsis discharges increased six-fold while lactate and CRP use remained unchanged. PCT use was associated with decreased odds of in-hospital mortality but increased hospital costs per day.

Findings show that a combination of CRP, PCT, TRAIL and IP-10 can identify bacterial infections with higher accuracy than single biomarkers and combinations of a single bacterial biomarkers combined with TRAIL and IP-10.

CGRP plays a role in human headache pathophysiology.

this study did not find a significant association of CALCA polymorphisms and the time to aseptic loosening after primary total hip arthroplasty in a Western European group.

Elevated PCT concentration may serve as a biomarker of worse outcome in patients with chronic heart failure with reduced ejection fraction.

CGRP expression in the infrapatellar fat pad of knee osteoarthritis patients is regulated by the COX-2/mPGES-1/PGE2 pathway.

PCT may not be sufficiently used as a sole marker of sepsis in neonates compared to CRP. PCT in conjunction with CRP and other tests for septic screen can aid in better diagnosis of neonatal sepsis.

Levels of CRP and PCT in CSF did not present greater accuracy in differentiating bacterial from viral meningitis compared to serum levels.

Medullary thyroid carcinoma (MTC) was histologically confirmed in all patients with positive procalcitonin (PCT) but not found in patients with negative PCT. Serum PCT levels were significantly higher in patients with MTC than in those without.

This is the largest data set evaluating PCT in neonatal and pediatric patients on extracorporeal membrane oxygenation (ECMO). A PCT value of 0.5 ng/mL had the most utility for determining the absence or presence of a bacterial infection in the setting of ECMO with a high sensitivity and negative predictive values.

The data shows a subgroup of patients 17/34 (50%) have either elevated PCT or CRP levels. This study is the first to report PCT values in antipsychotic drug-free patients with schizophrenia.

Procalcitonin is reliable in discriminating medullary thyroid carcinoma patients with active disease from those with no evidence of disease.

This retrospective cohort study aimed to identify the early postoperative kinetics of C-reactive protein (CRP) and procalcitonin (PCT) in children undergoing tetralogy of Fallot (ToF) correction.

PCT could be a promising marker of clinical deterioration to septic shock in acute cholangitis. Therefore, PCT might be used as a decision-supporting biomarker for urgent biliary decompression.

this study shows that pre-eclampsia affects procalcitonin production in placental tissue

peripheral concentration of procalcitonin (both immediate and average levels) might be an independent predictor for prognosis in myocardial infarction patients.

Patients with procalcitonin (PCT) above 0.25 mug/L are unlikely to have a unique diagnosis of flu.

The cut-off point of procalcitonin level for diagnosing sepsis in the meta-static solid tumor was higher compared to the standard value.

PCT is a useful marker for diagnosis of among catheter-related blood stream infection hemodialysis patients.

We reported here for the first time that CGRP inhibited the cardiac fibroblasts senescence and senescence-associated secretory phenotype in cardiac fibrosis via up-regulating the klotho expression. On the basis of our previous study, the present study further determined the protective role of CGRP in heart, with consequent therapeutic implications for heart failure.

activation of TRPV3 also plays a critical role in modulation of heat-induced vasodilation via a controlled release of CGRP in response to moderate heating of the skin.

CGRPalpha from within TRPV1-cre population plays an important role in visceral nociception but less so in somatic nociception.

Report a novel positive function of mm9_circ_009056 during osteogenesis in regulating BMP7 through miR-22-3p. Furthermore, the expression of mm9_circ_009056 was up-regulated in CGRP-induced cells, whereas miR-22-3p was decreased.

Hepatic PCT expression is upregulated in ALF. Hepatic macrophages but not hepatocytes are the cell source of hepatic PCT expression.

alphaCGRP overexpression causes an increase in thermal reaction and downregulation of the cardiovascular system, presumably due in increased levels of alphaCGRP.

The abundance of mRNA of CGRP and bone matrix markers (Col I, Col II, and OPN) was low at P5 in the tibia. These differences in CGRP and other mRNAs may induce a different manner of ossification between the mandible and tibia. Therefore, a time lag of ossification occurs between the mandible and tibia during foetal development.

Suggest that cochlear function is enhanced by maturation of CGRP receptor complexes.

These results suggest that CT acts as a hypocalcemic factor in calcium regulation, probably through inhibition of ECaC synthesis.

CGRP (CALCA) profil antigène

Antigen Summary

This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide and katacalcin by tissue-specific alternative RNA splicing of the gene transcripts and cleavage of inactive precursor proteins. Calcitonin is involved in calcium regulation and acts to regulate phosphorus metabolism. Calcitonin gene-related peptide functions as a vasodilator while katacalcin is a calcium-lowering peptide. Multiple transcript variants encoding different isoforms have been found for this gene.