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An infectious mononucleosis-like syndrome with lymphadenopathy and/or a flu-like illness develops in about 10–20% of patients

Nodes are discrete, variably tender, and do not suppurate

Cervical lymph nodes are most frequently involved, but any nodes may be enlarged

Less common findings

Fever

Malaise

Myalgias

Fatigue

Hepatosplenomegaly

Lymphopenia (usually < 10%)

Liver enzyme elevations

Unilateral chorioretinitis may occur

Acute toxoplasmosis in the immunodeficient patient

Patients infected with HIV, and those with lymphoma, leukemia, or transplantation, are at high risk for developing severe disease (most commonly central nervous system [CNS] disease, but also chorioretinitis, myocarditis, or pneumonitis) following acute infection or reactivation

Toxoplasmic encephalitis is a common cause of mass lesions in the brains of persons with HIV/AIDS

Ocular toxoplasmosis

Presents as a focal necrotizing retinochoroiditis often associated with a preexistent chorioretinal scar, and variable involvement of the vitreous, retinal blood vessels, optic nerve, and anterior segment of the eye

Appearance of the ocular lesion is not specific and mimics other granulomatous ocular diseases