Oh my!...
This study was, hopefully, done in the name of
Science, and yet, reading this study turned my
stomach...there must be another way to study the
effects of
bacterial flora on the ravages of internal
disease...The procedural protocols in this study just
seem downright unscientific and potentially harmful,
as well as morally/ethically unfair to the research
recipients receiving "feces" from a donor via usage of
the duodenal tube (transplant) procedure..

Dr William Martin

09/23/10

We are developing a more aesthetic version of fecal
bacteriotherapy which is safer and potentially more
effective with a view to employing it in the treatment
of C. difficile. The same procedure could be employed
with allogenic samples to treat obesity.
An autologous faecal sample, provided by the patient
before medical treatment, is stored in a refrigerator.
Should the patient subsequently develop C. difficile
the sample is extracted with saline and filtered. The
filtrate is freeze dried and the resulting solid
enclosed in enteric coated capsules. Administration of
the capsules will restore the patient's own colonic
flora and combat C. difficile (1). This procedure will
avoid the hazards of standard FB where infection from
the donor could be transmitted to the patient and the
requirement to deliver faecal samples into the
duodenum via a nasal probe.
1. Mediciments - UK Patent PCT/GB2010/051561
17 September 2010
[edit] Theoretical basis.

Gregory Ventana

09/23/10

Has anyone considered doing the same experiment substituting probiotics
for feces? What is the perceived benefit of transplanted flora vs. carefully
selected probiotics?.

val fitzgerald

09/23/10

Au contraire, Scholar--sounds incredibly cool to this
watcher. The immune system is so vast that most of us
outside some medical fields, don't even know that
it--of course--reaches to our reactions to the foods we
eat. And, it goes without saying, many (if not all) of
those reactions, are actually immune system
responses--acquired? inherited? If so, what mediates
which?. I'd love to know what the study showed. Do
obese recipients use the gut flora from the lean ones
effectively? Does the (lean) flora change to (obese)
ineffective flora? If so, what part of the immune
response (hepatic mediation) would cause the change? Is
is genetic? Wow, a lot of questions...and I'm
interested in every answer that study gives. Val (at
jvaljon1@yahoo.com, in case anyone wants to enlighten me!.

Scholar of Medicine

09/24/10

A noteworthy comment on the history of fecal-oral
transmittable diseases/infection was the massive dread
of Poliomyelitis...Because of Sabin's/Salk's research,
Polio Vaccines saved millions of people worldwide from
the ravages of Polio...Hopefully, a MRSA or C-Diff
vaccine will be forthcoming, and fecal transplants
via the duodenum will become questionable treatment....

Dr. Dubrawsky

01/15/11

This is a very unusual method to improve H.D.L.(Per
rectum).I hope that this approach is satisfactory to
the patients.
"Primum Non Nocere".

Reznik, MD

02/02/11

Evidence base medicine should be able to accept
facts, not the feelings. It is working for c dIFF BUT
NOBODY WANTS THIS THERAPY.
The cost of the therapy- penny. We are ready to spend
on medications thousands a month to lower HbA1c from
9 to 8. The therapy could be so cheap- nobody is
going to do any study on it in the USA, nobody will
invest a cent to study this therapy here. Avarage
cost of approval by FDA 180.000.000$. It is the way
to eleminate all affordable medications, therapies
from the market( look on NTG, colchicine and other
medications we had used for a century).
For us- it just a fun to discuss what other medical
scientists can do in another countries..

Jeanniejayne, MSN, RN

02/24/11

We could do so much better by putting more nutritional
support into practice. There was a Dutch study in
which surgical candidates for bowel resection were
given probiotics for several days before surgery,
fasted for just one day and cleansed the bowel, and
returned to oral nutrition soon after surgery. They
did much better post-operatively than those treated as
is usual in the US, where we weaken the patient by
putting them on TPN for several days pre-and post-op
when undergoing such procedures, which require great
reserves for healing. The gut has much more to do with
overall health than we give it credit for. One needs
only to look at the link between the gut and the
inflammatory response in ulcerative colitis and
Crohns's disease for examples..

elizabeth mangieri-omps, fnp-c

03/22/11

Agree With Jeanniejayne, above. The anus is an EXIT not an ENTRANCE
and inasmuch as the beginning to the GI system is the ORAL route, the
answer lies there and NOT at the terminal end! Please - can we use a
bit of common sense for a change? C-Diff originates from a surfeit of
ABX in the first place! Insulin resistance originates in the deleterious
effects of what we place IN OUR MOUTHS. When we reach a point that
a thin person's excrement must be implanted into the bowel of the
obese patient it's time to stop and say: WHAT????? If it is a life saving
answer, that is one scenario, but to say that dung from the thin guy is
going to lower A1C and make any significant difference in LIFESTYLE
which caused the condition in THE FIRST PLACE is fodder for late night
comedians.
As to the 3rd party reimbursement for fecal transplants in the wake of
slashing budgets in healthcare - I won't even go there.
There are patients out there who have never eaten a fresh vegetable,
or a piece of fruit or tasted yogurt, EVER. How about we start there and
keep in mind that the GI tract starts in the mouth and that the rectum
is an EXIT, not and ENTRANCE. Thank you..

interested RN

03/28/11

I wonder how you'd go about "selling" this procedure
to Americans, no matter how ill they might be..

This survey is a poll of those who choose to participate and are, therefore, not valid statistical samples, but rather a snapshot of what your colleagues are thinking.

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