PERIPHERAL NEUROPATHIES

Peripheral neuropathy is the result of damages of the peripheral nervous system. These disorders can be caused either by a trauma or diseases as for example diabetes.
NEUROFIT proposes animal and cellular models useful for the evaluation of the neuroprotective activity of your coumpounds.

VINCRISTINE : model of chemotherapy induced neuropathy

Vincristine is widely used as an antimitotic drug for treating various cancers. However, its employment is often limited by their neurotoxicity, including peripheral neuropathy.Neurofit developed this model to assess the neuroprotective properties of compounds aiming to counteract chemotherapy side effects.

Vincristine induces cell death and destruction of neurite network in sensory neurons and Schwann cells co-culture from rat embryos. NGF at 5 ng/ml is able to protect neurons against the cisplatin damage.