Comparison of guanylate cyclase activity of the heart and thrombocytes in normal states and in experimental allergic myocarditis

Abstract: Activity of soluble forms of guanylate cyclase from rabbit heart and thrombocytes was studied under conditions of normal state and in dynamics of heart allergic impairment: at the step preceding the impairment (step of sensitization), at the acute period (I-st day of the allergy) and at the step of reparation (14 day of the disease). The enzymatic activity was found to be 15-20-fold higher in thrombocytes as compared with that of heart muscle. Two-fold activation of the thrombocyte guanylate cyclase was detected at the step of sensitization; at the acute period the enzyme activity was distinctly decreased (below the values of normal state) an then normalized to the step of reparation. The similar but less distinct trend was observed in alterations of activity of myocardial guanylate cyclase. The data obtained suggest the conformity of the enzymatic properties in myocardium and thrombocytes under conditions of normal and pathological states.