Mantis

Pages

Monday, November 28, 2016

Cannabis For Brain tumor First Human Trials Begins

Cannabis For Brain tumor First Human Trials Begins

Cannabis For Brain tumor Sativex is an oral spray made from ingredients derived from the whole cannabis plant. The two main compounds in cannabis CBD and THCBrain tumor are present in Sativex in an equal 1:1 ratio.

Both cannabis compounds (known as cannabinoids) have shown anti-cancer properties in pre-clinical studies, and seem to be effective against a wide range of cancers.Brain tumor Anecdotal reports also suggest that cannabis and cannabinoids have the ability to fight cancer.However, GW Pharmaceuticals is the first company to initiate clinical research on cannabis-based medicine as a cancer therapy.

“We are very excited about moving this compound into more humans study and the prospects of cannabinoids as new anti-cancer treatments. This is GW’s first clinical study of cannabinoids as a potential treatment to inhibit tumor growth.”The company plans to investigate Brain tumor Sativex as an add-on to the standard chemotherapy agent temozolomide, rather than a stand-alone. According to GW Pharmaceuticals, pre-clinical research suggests that cannabinoids can improve the anti-cancer ability of temozolomide.

The Phase 1b/2a trial announced on Monday will involve 20 patients with recurrent glioblastoma multiforme (GBM), an aggressive and rare form of brain cancer that accounts for about 50% of all brain cancers diagnosed in the U.S. each year. The trial will first have to prove the safety of the combined treatment regimen before further research can be done on its effectiveness.

In the U.S., clinical trials of cannabinoids for cancer are also expected in the near future. Sean McAllister, Ph.D and his colleagues at California Pacific Medical Center hope to begin the first human studies of CBD for breast cancer within the next 12 months.Sativex is currently approved in more than 20 countries for the treatment of multiple sclerosis symptoms and is also being studied as a treatment for cancer pain.

While Sativex has been GW’s leading product, the company has a number of other cannabinoid-based drugs in its pipeline, including an epilepsy drug called Epidiolex.Epidiolex, which contains more than 98 percent CBD, recently began clinical trials in the U.S. and U.K as a treatment for pediatric epilepsy.