Osteoclast

osteoclast

[′äs·tē·ə‚klast]

(histology)

A large multinuclear cell associated with bone resorption.

(medicine)

A large surgical apparatus through which leverage can be exerted to effect osteoclasis.

Osteoclast

a cell that is involved in the destruction and resorption of bone tissue in vertebrate animals and man. An osteoclast contains from three to several dozen nuclei and a great many lysosomes, whose hydrolytic enzymes upon release from the osteoclasts resorb the mineral matrix of bone and calcified cartilage.

24) With the background that RANKL/RANK signaling is essential for osteoclast formation, major studies have focused on the area to determine the full extent of the involvement of RANKL in osteoclast biology and common bone diseases.

By targeting the receptor activator of nuclear factor-kappaB ligand (RANKL), which is the primary mediator of osteoclast formation, denosumab blocks the production of the bone-destroying osteoclasts and by so doing improves the density, volume, and strength of both cortical and trabecular bone, according to the authors (N.

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