Relationships Between Inflammatory Biomarkers and Frailty

Inflammation underlies many diseases and previous research supports a role for some inflammatory markers to be associated with frailty. In a recent study with Prof David Le Couteur and colleagues from the ANZAC Institute, APAF conducted a large-scale screen using multiplexed immunoassays to quantitate 27 cytokines and chemokines from plasma of older men (>70years) in the CHAMP study “Concord Health and Ageing in Men Project”.

From: Cross-Sectional and Longitudinal Relationships Between Inflammatory Biomarkers and Frailty in Community-dwelling Older Men: The Concord Health and Ageing in Men Project

The studies findings confirm that IL-6 and IL-8 may be cross-sectionally associated with frailty. The authors concluded that frailty is specifically linked to IL-6 and IL-8 rather than simply representing a nonspecific pan-inflammatory condition.