Anyone familiar with the Cyanide and Happiness comics will know Seizure Man. Shouldn't come as a surprise, but they're not particularly PC XD

In Britain, we have a wee bear that's the mascot of Children in Need called Pudsey (which is also a town near Leeds). He has a bandage over one eye, and it must be said some pretty sweet dance moves :3

Batman? being a superhero without superpowers...now THAT's a disability:))

Uhm anime/manga Midori Days(Midori no Hibi), the main character has another person instead of a hand )
School Days?...(brain damaged?) <-----also NEVER EVER FOREVER watch this 12ep anime more than ONCE in your generation ) maybe DON'T watch it at all...
Golden Times, memory loss could be dissability?