OXFORD, Mississippi - Ole Miss sophomore quarterback Shea Patterson of Shreveport came into Saturday night's LSU game averaging 357 yards passing a game for No. 1 in the Southeastern Conference and No. 3 in the nation.

He finished with the worst game of his young college career, completing just 10 of 23 passes for 116 yards with three interceptions around three sacks in a 40-24 loss to No. 25 LSU at Vaught-Hemingway Stadium. The former Calvary Baptist star who was the No. 1 prep quarterback in the nation by Rivals.com when he signed with Ole Miss in 2016 had a better game against No. 1 Alabama last month when he completed 14 of 29 for 165 yards with two interceptions amid five sacks.

"We locked Ole Miss down," said LSU cornerback Kevin Toliver II, who had one of LSU's three interceptions along with a pass breakup. "Everybody thought they were going to just throw the ball around on us."

Patterson did play part of the game hurt, however, as he suffered a knee sprain in the second quarter and left the game briefly. He returned in the third quarter, but left the game again. Bruce Feldman of Fox Sports tweeted Sunday that Patterson may be out for the year.

Safeties John Battle and Grant Delpit had the other two interceptions for the Tigers (6-2, 3-1 SEC). Outside linebacker Arden Key, who has been slow to return to his 2016 All-SEC form after shoulder surgery and not participating in spring drills, sacked Patterson twice and had a season-high six tackles. Defensive end Christian LaCouture also collected a sack among his four tackles. Defensive end Rashard Lawrence had a quarterback hurry and two stops.

Brown, who entered the game leading the SEC with 113 yards a game, 35 catches, 678 yards, six touchdowns and a 5.8-catch-per-game average, managed four catches for 39 yards.

Lodge caught two passes for 18 yards after coming in averaging 73 yards a game for fourth in the SEC. Jefferson caught two passes for 23 yards after coming in with an average of 4.7 catches a game for fifth in the SEC. Metcalf, averaging 4.2 catches a game, caught one pass for 15 yards.

"I love it," said LSU cornerback Donte Jackson, who had five tackles. "I like to tell the defensive backs that it's on us. We give up a play, and that's what people see. But if we make a play, that's also what people see."

LSU played like its self-proclaimed moniker, Defensive Back U., Saturday.

"I thought our DBs had a heck of a game, considering the passing game that they have and the quarterback, and those wide receivers are tremendous," LSU coach Ed Orgeron said. "We challenged our team to play with a sense of urgency. We had to. We knew their quarterback was dangerous. This is a team that can score any time."

Patterson was 5 of 9 for 33 yards with an interception and two sacks in the first half before leaving the game in the second quarter with the knee injury. Junior college transfer Jordan Ta'amu replaced Patterson both times. He completed 7-of-11 passes for 78 yards for the Rebels (3-4, 1-3 SEC).

"We didn't make the plays we needed to make on offense," Ole Miss coach Matt Luke said. "We had several opportunities. We just didn't make them."

The Tigers are open this Saturday before traveling to play at No. 1 Alabama (8-0, 5-0 SEC) on Saturday, Nov. 4, at 7 p.m. CBS.