An international research team has evolve a polysome-based technique for detecting microRNAs (miRNAs) that act to encourage or sustain growth of acrimonious mesothelioma and other types of cancer. MicroRNAs are short RNA molecules about 22 nucleotides in length. Essentially, miRNAs specifically target obvious messenger RNAs (mRNAs) to prevent them from coding for a distinct protein….

A novel approach to preventing diabetes and other expression of metabolic syndrome, which includes obesity, diabetes, and fatty liver disease, showed promising results in mouse model systems. The response by the liver to fasting has been present as a therapeutic pathway to boost hepatic and whole-host metabolism. However, the mechanisms underlying these metabolic consequences remain…

A team of cancer researchers working with a mouse model has found that a chemical creates during digestion of vegetables such kale, cabbage, and broccoli activates a protein that helps maintain the sincerity of the cells lining the gut – preventing chronic inflammation that has been implicated in the development of colon cancer. The epithelium…

A variation of the CRISPR/Cas9 genome-editing tool enables more precise manipulation of target genes by not breaking double-stranded DNA and rather reassemble a single point in the targeted DNA sequence. CRISPR gene editing has restructured biomedicine and biotechnology by providing a simple means to engineer genes through targeted double-strand breaks in the genomic DNA of…

Researchers from the University of Sydney, CSIRO, the United Kingdom’s John Innes Centre, Limagrain UK and the National Institute of Agricultural Botany (NIAB) have isolated the first major resistance genes against the harmful stripe rust disease that is devastating wheat crops worldwide. The finding by the scientists, who have cloned three associated rust resistance genes…

A new breed of canola proved its value in trials conducted at Kojonup last season. Nuseed’s first hybrid triazine tolerant diversity, HyTTec Trophy, was put through its paces by the local grower and Landmark agronomist Kent Stone. He was part of Nuseed’s national Crop Agronomy Trial program, which gives chance to growers to test the…

A recently described class of microRNA has been related to the cancer-promoting activity of the mutated form of p53 protein. MicroRNAs (miRNAs) and short interfering RNAs (siRNA) comprise a class of about 20 nucleotides-long RNA fragments that block gene expression by bind to molecules of messenger RNA in a fashion that block them from transmitting…

Earlier studies have revealed that in contrast to the situation in CAFs, p53 in normal fibroblasts (NFs) plays a tumor-suppressive role to restrict tumor growth. Cancer researchers have found that changes happen in the tumor microenvironment manipulate the activity of fibroblast p53 protein, causing it to boost rather than restrict cancer growth. This transcriptional rewiring…

A novel therapeutic approach uses drugs encapsulated within galacto‐oligosaccharide gel capsules to attack diseases that have assembled a high percentage of senescent cells. Senescent cells are aged or harm cells that no longer are able to perform their normal roles. In a model of chemotherapy‐induced senescence, gal‐encapsulated cytotoxic drugs targeted senescent tumor cells and upgrades…

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The Pakistan Biotechnology Information Center (PABIC) was established at Latif Ebrahim Jamal National Science Information Center, University of Karachi under the patronage of International Service for Acquisition of Agri-Biotech Applications (ISAAA) and National Commission on Biotechnology. Read more