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“Don’t get me wrong, all the GPs at the practice are lovely but Dr Kinston is the only doctor I felt completely at ease with and who fully understood my problems.”

Another, Helen Tucker, said: “I hope Dr Elizabeth Kinston comes home soon. She is the best doctor I have ever met and always has time to listen.”

Dr Kinston, who has two daughters, Sophia and Elise, was on maternity leave after Elise’s birth in January.

She left home at some point after 10am last Friday and was pictured walking along Carrington Street and Queens Bridge Drive in Nottingham city centre at around 11.40am.

She was then spotted again on CCTV at 11.58am, walking along Queen’s Drive, towards the junction with Castle Bridge Road.

The Audi was later found in the car park of the city’s Broadmarsh shopping centre with her purse and mobile phone inside.

In a fresh appeal today, her sister Charlotte Naaman, 35, said: “Lizzie has such a big heart. She loves her job as a doctor and I know she gets so much joy from being able to help people feel better.

“She is also a loving mum, who would do anything for her girls.

“Her caring and kind nature is something that makes her memorable and there are a lot of people out there who she will have helped and who would recognise her if they saw her.

“I’m now asking them to return the favour and help her.”

Begging her sister to get in contact, she told her Mr Kinston, 36, and their daughters “miss you terribly.”

She added: “We understand if you need time away to focus on yourself for a while, but please just pick up the phone or drop us an email to let us know you are ok.”

Nottinghamshire Police were meanwhile continuing to trawl CCTV as part of their efforts to find her.

Det Insp Marcus Oldroyd said: “As time passes our concern grows. We have a team of officers looking for Elizabeth, as well as hundreds of people out there who are sharing our posters and appeals and keeping their eyes peeled.

“There are a lot of people out there who obviously care about her welfare and want to see her home safe with her family.”