The back cover picture depicts the beauty and significance of water molecules, key structural components in the architecture of living systems, for the rational design of small molecules with tailored biological activity. A potent and selective inhibitor of the therapeutically relevant target matrix metalloproteinase 13 was realized, without any screening activities, by a concise structure-based approach targeting multiple water molecules as binding partners. For more details, see the Communication by Rainer Riedl et al. on p. 1457 ff.