CONTEXT: Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary kidney disease and extrarenal manifestations may be observed in many organ systems. Hypothalamus-pituitary-adrenal axis in patients with ADPKD was not evaluated extensively.

OBJECTIVE: We aimed to evaluate the hypothalamus-pituitary-adrenal axis in ADPKD patients.

METHODS: Twenty two ADPKD patients and 27 healthy subjects were enrolled. Basal dehydroepiandrosterone-sulfate (DHEAS) levels and cortisol and dehydroepiandrosterone responses to low dose short adrenocorticotropin stimulation test were assessed. Correlation analyses of these parameters with glomerular filtration rates, renal volumes and pain characteristics in patients with ADPKD were done.

Eligibility

Ages Eligible for Study:

20 Years to 56 Years

Genders Eligible for Study:

Both

Accepts Healthy Volunteers:

Yes

Criteria

Inclusion Criteria:

Healthy subjects

Diagnosis of autosomal dominant polycystic kidney disease

Exclusion Criteria:

A glomerular filtration rate below 60 ml/min

History of recent major surgery

Systemic infections with fever

Significant hirsutism (Ferriman Gallwey score≥8)

Congenital adrenal hyperplasia

Late onset congenital adrenal hyperplasia

Systemic corticosteroid use (including previous use)

Topical corticosteroid use

Menstrual irregularity

History of thromboembolism

Uncontrolled diabetes or hypertension

History of psychosis

Pregnancy

Lactation

History of hypersensitivity to tetracosactin

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Please refer to this study by its ClinicalTrials.gov identifier: NCT00598377