The evolution of the Internet of Things (IoT) is changing the nature of edge-computing devices. End nodes have to support, in place, an increasing range of functionality: multi-sensory data processing and analysis, complex systems control strategies, and, ultimately, artificial intelligence. These new capabilities will enable disruptive innovation in wearable and implantable biomedical devices, autonomous insect-sized drones, autonomous smart environmental sensing, safety-critical real-time applications and structural health monitoring, and more. For this special issue, we are seeking contributions on IoT smart edge-computing architectures, systems, and related hardware-software design approaches. Topics of interest include, but are not limited to: