Check the appropriate box to designate the
rule pursuant to which this Schedule is filed:

x Rule
13d-1(b)

o Rule
13d-1(c)

o Rule
13d-1(d)

*The remainder of this cover page shall be
filled out for a reporting person’s initial filing on this form with respect to the subject class of securities, and for
any subsequent amendment containing information which would alter disclosures provided in a prior cover page.

The information required in the remainder of
this cover page shall not be deemed to be “filed” for the purpose of Section 18 of the Securities Exchange Act of 1934
(“Act”) or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions
of the Act (however, see the Notes).

CUSIP No. 16934W106

SCHEDULE 13G

Page 2
of 6 Pages

1

NAME OF REPORTING PERSONS

ArrowMark Colorado Holdings LLC

2

CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

(a) o

(b) o

3

SEC USE ONLY

4

CITIZENSHIP OR PLACE OF ORGANIZATION

Delaware, United States

NUMBER OF

SHARES

BENEFICIALLY

OWNED BY

EACH

REPORTING

PERSON

WITH

5

SOLE VOTING POWER

2,707,986

6

SHARED VOTING POWER

0

7

SOLE DISPOSITIVE POWER

2,707,986

8

SHARED DISPOSITIVE POWER

0

9

AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

2,707,986

10

CHECK
IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES

o

11

PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

5.7%

12

TYPE OF REPORTING PERSON

IA

CUSIP No. 16934W106

SCHEDULE 13G

Page 3
of 6 Pages

Item 1.

(a) Name of Issuer

Chimerix, Inc.

(b) Address of Issuer’s Principal
Executive Offices

2505 Meridian Parkway, Suite 100

Durham, North Carolina27713

Item 2.

(a) Name of Person Filing

ArrowMark Colorado Holdings LLC

(b) Address
of Principal Business Office, or, if none, Residence

100 Fillmore Street, Suite 325

Denver, Colorado 80206

(c) Citizenship

Please refer to Item 4 on each cover sheet for each filing person

(d) Title of Class of Securities

Common Stock

(e) CUSIP No.:

16934W106

CUSIP No. 16934W106

SCHEDULE 13G

Page 4
of 6 Pages

Item 3. If
this statement is filed pursuant to §§240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:

(a)

¨

Broker or dealer registered under section 15 of the Act (15 U.S.C. 78o);

(b)

¨

Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c);

(c)

¨

Insurance company as defined in section 3(a)(19) of the Act (15 U.S.C. 78c);

(d)

¨

Investment company registered under section 8 of the Investment Company Act of 1940 (15 U.S.C. 80a-8);

(e)

x

An investment adviser in accordance with §240.13d-1(b)(1)(ii)(E);

(f)

¨

An employee benefit plan or endowment fund in accordance with §240.13d-1(b)(1)(ii)(F);

(g)

¨

A parent holding company or control person in accordance with §240.13d-1(b)(1)(ii)(G);

A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the
Investment Company Act of 1940 (15 U.S.C. 80a-3);

(j)

¨

A non-U.S. institution in accordance with §240.13d-1(b)(1)(ii)(J);

(k)

¨

A group, in accordance with §240.13d-1(b)(1)(ii)(K). If filing as a non-U.S. institution in accordance with §240.13d-1(b)(1)(ii)(J),
please specify the type of institution:

CUSIP
No. 16934W106

SCHEDULE 13G

Page
5 of 6 Pages

Item
4. Ownership

Provide the following information
regarding the aggregate number and percentage of the class of securities of the issuer identified in Item 1.

(a) Amount beneficially owned:
2,707,986

(b) Percent of class: 5.7%

(c) Number of shares as to which
the person has:

(i) Sole power to vote
or to direct the vote: 2,707,986

(ii) Shared power to vote
or to direct the vote: 0

(iii) Sole power to dispose
or to direct the disposition of: 2,707,986

(iv) Shared power to dispose
or to direct the disposition of: 0

Item
5. Ownership of Five Percent or Less of a Class

Not Applicable

Item
6. Ownership of More Than Five Percent on Behalf of Another Person

Not Applicable

Item
7. Identification and Classification of the Subsidiary which Acquired the Security Being Reported on by the Parent
Holding Company or Control Person

Not Applicable

Item
8. Identification and Classification of Members of the Group

Not Applicable

Item
9. Notice of Dissolution of Group

Not Applicable

Item
10. Certification

By
signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held
in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or
influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant
in any transaction having that purpose or effect.

CUSIP No. 16934W106

SCHEDULE 13G

Page 6
of 6 Pages

SIGNATURE

After reasonable inquiry
and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.