Most species of the genus Clostridium are saprophytic organisms found in many places in the environment, most notably the soil. However, the genus does contain some human pathogens (outlined below).
The toxins produced by certain members of the genus Clostridium are among the most dangerous known. Examples are tetanus toxin (known as tetanospasmin) produced by C. tetani and botulinum toxin produced by C. botulinum. Some species have been isolated from women with bacterial vaginosis.[2]

Contents

Epidemiology

Since they are commonly found in soils and in microbiota of humans and animals, Clostridia wounds and infections are found worldwide. Host defenses against the microbe are nearly absent, and very little innate immunity exists, if any. Clostridia can be diagnosed by recognizing the characteristics of the lesion of the infection along with Gram stains of the tissue and bacterial culture.[1] Although the body does not have adequate defenses alone, this microbe can be controlled with the help of antibiotics, like penicillin, and tissue debridement for the more severe cases.

Clostridia and mental health

Clostridia bacteria are commonly found in the gut-microbiome. Overuse of antibiotics can cause imbalance of the gut microbiome, leading to overgrowth of the species Clostridioides difficile causing a serious infection (CDI).[8] Effects of this infection can lead too severe diarrhea and also the increase in severity of many bowel related diseases is also increased as a results of the infection. Other Clostridia bacteria in the gut have been linked to brain connectivity and healthy function.[9]

Patients that have been subjected to fecal microbiome transplants to treat their CDI have seen improvements in their mood and mental health.[8] Indicating the presence of Clostridia in the gut microbiome means an improved mental health. Clostridia, through research, is being seen as a microbe linked to improved mental health. Gut microbiome transplants are seen as a possible future avenue for treating mental health disorders.