This function enables you to search for a Keystone Symposia meeting by any word in the meeting title, location, organizer names, meeting summary or sessions (including session names, speaker names and talk titles).

SEARCHING BY A NAME: If you are searching based on a person's name, it is best to enter only part of the name, OR to enter the First Name, the word 'AND', and the Last Name, like this: "James AND Aiken".

KEYWORD(S) ENTERED

WOULD RETURN...

Aiken

James Aiken, Jim Aiken, Robert Aiken, Walter Aikenstein

James AND Aiken

James Aiken, James W. Aiken, James R. AikenWould NOT find: Jim Aiken, Robert Aiken, James Taylor

James OR Aiken

James Aiken, James W. Aiken, James R. Aiken, Jim Aiken, Robert Aiken, James Taylor, James Johnson, Jesse James

We often list the person's full name with the Middle Initial.See 'Combined Words' below for more details.

Searches on the Keystone Symposia website can be modified to narrow or expand your search criteria using the terms listed below.

TERM

USE

EXAMPLE

AND

Used to narrow your search.

Cancer AND MicroRNA - would return any meetings/abstracts with both 'Cancer' and 'MicroRNA'. If just one of these terms exist, the meeting/abstract would not be returned in the search. See NOTE below

OR

Used to expand your search.

Cancer OR MicroRNA - would return any meetings/abstracts with either 'Cancer' or 'MicroRNA'. If just one of these terms exist, the meeting/abstract would be returned in the search. See NOTE below

You may use commas instead of the word OR...so 'Cancer OR MicroRNA' is the same as 'Cancer, MicroRNA'.

NOT

Used to narrow your search.

Cancer NOT MicroRNA - would return any meetings/abstracts with 'Cancer' but not 'MicroRNA'. If both of these terms exist, the meeting/abstract would not be returned in the search. See NOTE below

Combined Words

Used to narrow your search.

Cancer MicroRNA - would return any meetings/abstracts with 'Cancer MicroRNA', but not meetings with only 'Cancer', or only 'MicroRNA', or both words...it is expecting to find the term 'Cancer MicroRNA' which is unlikely. The better way to search would be to use 'Cancer AND MicroRNA' or 'Cancer OR MicroRNA', depending on what you were searching for. See NOTE below

Wildcards

Asterisk (*) - Used to expand your search...helpful if you know a part of a word, or part of a name you are looking for.

By default, any keyword you enter on the Keystone Symposia website will be 'wildcarded', so there is no need to enter a special character at the end of your term, such as an asterisk.

NOTE: When using 'AND', 'OR', and 'NOT', the FIRST word must be an exact match...

For example, searching for "Canc AND MicroRNA" is not the same search as "Cancer AND MicroRNA"; the first search would NOT return records with 'Cancer', only the second search would because the full word Cancer was typed.

Keystone Symposia aims to advance life science discovery through exchange and dialogue among a diverse community
of scientists participating in our high-quality research conferences throughout the world. In this spirit, all
Keystone Symposia events are open to all, and the organization strives for an inclusive and welcoming environment.
We highly value diversity of opinions and experiences at our conferences and in the scientific community.
The participation of scientists from ALL countries and backgrounds is extremely important to our organization.

The recent White House Executive Order could potentially restrict the scientific diversity at Keystone Symposia
conferences, thereby diminishing the excellence of our meetings, thwarting efforts toward inclusion of all attendees
and discouraging collaboration among different scientific cultures that is vital to the advancement of science.
At Keystone Symposia, we remain committed to these principles. We are therefore working on behalf of all those
who wish to attend Keystone Symposia conferences to ensure that they receive the attention needed to facilitate
their attendance within the boundaries of the law in this very fluid situation.

We are aware that this Executive Order, if reinstated, may impact not just scientists, students and postdoctoral
fellows who are nationals of the affected nations, and living in those countries, but also nationals of those
countries who are now working or studying elsewhere. Reinstatement may also result in changes in the visa
issuance process that could delay approval of visas required for nationals from certain countries who wish
to attend our conferences. Anyone affected who has submitted an abstract or registered for one of our upcoming
conferences but who may no longer be able to attend the conference due to the Executive Order should not hesitate
to contact our Attendee Services Department (+1 800-253-0685; +1 970-262-1230; info@keystonesymposia.org)
for assistance.

Summary of Meeting:Nuclear receptors (NRs) represent a large superfamily of ligand-dependent transcription factor “sensors” for a diverse set of fat-soluble hormones, vitamins and dietary lipids. NRs orchestrate genetic response programs critical for normal homeostasis, and are required for reproduction, development, metabolism and immune function. For this reason, NRs have been investigated for over 30 years as promising targets for drugs to treat a broad spectrum of diseases including cancer, diabetes and other endocrine or metabolic disorders, obesity, cardiovascular disease, hypertension, inflammation and cholestasis. Research on NRs has led to numerous successful therapies for deadly diseases that have improved both longevity and quality of life. However, significant hurdles remain that involve further detailed understanding of the major gene regulatory networks regulated by NRs, how these differ in normal relative to pre-disease and disease states, and the complex problems associated with targeting tissue-specific effects (to reduce side effects) and circumventing mechanisms of resistance. Thus, further insight into the full range of NR functions and interactions with co-regulatory molecules and signaling pathways is necessary for combinatorial approaches involving NRs in health and disease, and development of next-generation therapies. This meeting on “Nuclear Receptors: Full Throttle” continues the Keystone Symposia tradition of bringing together a diverse array of our leading scientists, including senior and junior investigators and their trainees, from academic, clinical and pharmaceutical settings, to showcase the latest science, highlight the use of innovative and emerging technologies, explore new directions, and develop collaborative and synergistic efforts in the exciting field of NR biology.