"...Oscorp physicist Dr. Otto Octavius dug into Curt Connors’ research as quickly as it became available to him. Not satisfied with simply infusing human DNA into a highly venomous black fat-tailed scorpion, Octavius also threw in a touch of a mysterious, organic “black goo” of unknown origin, which Oscorp had recently retrieved from one of the company’s fallen satellites in secret. The result was Scorpion..."

Not only does Doc Ock exist in this universe, but so does this "black goo," which has to be the symbiote that goes on to become Venom in common Spider-Man lore. What makes this so interesting is that Amazing Spider-Man Producer Doug Heder talked extensively on Up at Noon about how Marvel and the movie folks had to approve everything in the game and that the game had to stay away from villains Sony Pictures might have plans for. So even though the Activision bio reads "This bio is intended only as back story. Neither Dr. Otto Octavius nor the “black goo” appear in the film The Amazing Spider-Man or its videogame," it's establishing a world. It's canon

Basically, the game could be establishing the fiction for the sequel to The Amazing Spider-Man movie, and that fiction now includes Doc Ock and the symbiote in some fashion.