Alliance of Genetic Support Groups, Inc A non-profit organisation founded in 1986;a national coalition of consumers, professionals and genetic support groups. The site includes details of AGSG, a Directory of Genetic Organisations, resources, on-line newsletter, publications etc.

BCM Search Launcher - Baylor College of Medicine (USA) This site provides a single point-of-entry for sequence searches accross molecular biology-related search and analysis services available on the WWW. Searches include multiple and pairwize sequence alignments.

Breast Cancer Information Core An on-line breast cancer mutation database. This is an international collaboration hosted by the NIH National Human Genome Research Institute. The Web site includes the database (requires registration), laboratory methods, forum and resources.

Cancer Genetics Working Group (National Cancer Institute, USA) Part of the NCI Division of Cancer Epidemiology and Genetics. It is involved in the Cancer Genetics Network and other initiatives to define opportunities for cancer genetics research.

Cancer Genome Anatomy Project (National Cancer Institute, USA) CGAP is an interdisciplinary program to establish the information and technological tools needed to decipher the molecular anatomy of the cancer cell. resources for genes, breakpoints etc.

Cancer Genome Anatomy Project / Database (National Cancer Institute + partners) aims to establish complete index of genes expressed in tumors. A growing database sorted by anatomical site, from which gene sequences can be downloaded. It includes details of reagents and methodology.

CAPP: Colorectal Adenoma / Carcinoma Prevention Programme An international project which aims to find out how to prevent bowel cancer with the help of families with a genetic predisposition to the disease (FAP and HNPCC). The site includes details of clinical trials and patient information. Office in Newcastle.

Database of Single Nucleotide Polymorphisms (National Center for Biotechnology Information) A public database of single base nucleotide substitutions and short deletion and insertion polymorphisms. Users can search for and submitt SNPs.

Environmental Mutagen Society Founded in 1969, this is a scientific society fostering research on the basic mechanisms of mutagenesis and applying this knowledge in genetic toxicology. The Web site includes details of meetings, membership, journal, newsletter, and interest groups.

Fanconi Anemia Mutation Database An international collaborative database co-ordinated by Rockefeller University (USA) and Guy's Hospital (UK). The site includes public and private databases, reference sequences and related links.

Genetics of Cancer Website (Robert H. Lurie Cancer Center, Northwestern University Medical School, USA) The web site has resources for the public, physicians and researchers. There is an open news group, case histories, and detailed information on cancer genetics.

Human Genetics The Journal's web pages include table of contents and abstracts for publications from 1995, subscribers can download articles in PDF format. Mutations can be submitted via the Web page for inclusion in the journal and HGMD database.

Microarray User Group This is a Special Interest Group of the National Institutes of Health. It is a forum for users of glass or filter cDNA arrays to share information and reagents. The Web site includes details of membership, meetings and seminars, and Email archives.

MRC Human Genetics Unit (Edinburgh University, UK) Including research into the molecular genetics of colorectal cancer and Wilms' tumour

National Center for Genomic Resources (USA) The center is located in Santa Fe, New Mexico. It maintains a public, continually updated database of DNA data from all species. The Web site includes software tools (Gepasi, Blast, Sequence viewer etc.) to search, compare, and visualize data.

Links for Chemists (Liverpool University, UK) The site began in 1995 and provides links to chemistry related resources (7,315 links at 09/1999) sorted by topics, organisations, university departments, companies, software etc. German and French language support.

Anthony Nolan Research Institute (Royal Free Hospital, London, UK) The home page of ANRI includes information about the various research groups, staff, and publications. Work at the institute includes research into Immunotherapy, HLA, GvHD, GvL, Structural Immunobiology

Basic Research Laboratory - NCI (USA) This is part of the NCI Division of Basic Sciences, located in Bethesda. Research focuses on the cellular, molecular, genetic, biochemical and immunological mechanisms affecting the progression, diagnosis and treatment of cancer.

Cold Spring Harbor Laboratory (New York) The Laboratory was created in 1890 and its programs focus on cancer, neurobiology and plant genetics. It is a NCI designated Cancer Center. The Web site includes details of research and educational resources.

Division of Cancer Biology (Bethesda, MA, USA) The Division was formed in 1995 and supports a program of basic and applied research on cancer cell biology, including research on carcinogenesis and cancer immunology.

Gray Cancer Institute, Mount Vernon Hospital (UK) The Institute specialises in radiation research applied to cancer treatment. It is a registered charity working in conjunction with clinicians at Mount Vernon Hospital. The Web site includes details of research, publications, courses and reports.

Laboratory of Genetics (National Cancer Institute, USA) The laboratory was founded in 1982 and investigates the genetic mechanisms in neoplastic development. It is part of the NCI Division of Basic Sciences.

Laboratory of Genomic Diversity (National Cancer Institute, USA) LGD is located at the Frederick Cancer Research and Development Cente and is part of the NCI Division of Basic Sciences. The Web site includes details of LGD, publications, and the Cat Genome Project.

Laboratory of Human Carcinogenesis (National Cancer Institute, USA) The laboratory investigates the molecular basis of cancer. The Web page has details of the laboratory including the sections of Molecular Genetics, Liver Carcinogenesis, and Molecular Epidemiology.

Laboratory of Leukocyte Biology (National Cancer Institute, USA) The work of the laboratory includes determining the genes responsible for the growth and differentiation of hematopoietic stem cells, and characterizing mechanisms of retroviral infection in leukocytes.

Laboratory of Metabolism (National Cancer Institute, USA) This laboratory is part of the NCI Division of Basic Sciences and is involved in research into metabolism related to cancer including work on cytochrome P450.

Laboratory of Molecular Biology (National Cancer Institute, USA) The laboratory applies genetics, molecular biology, cell biology, and molecular modeling to investigate cancer biology. The Website includes details of the Laboratory and its constituent sections and research programs.

Laboratory of Molecular Carcinogenesis (National Cancer Institute, USA) The laboratory is part of the NCI Division of Basic Sciences. Research interests include enzymes of drug metabolism, interaction of carcinogens, and genetic and environmental factors in metabolism.

Laboratory of Molecular Cell Biology (National Cancer Institute, USA) The laboratory is part of the NCI Division of Basic Sciences. The main research focus is on eukaryotic chromatin structure and gene regulation.

Laboratory of Molecular Immunoregulation (National Cancer Institute, USA) The Laboratory is located at the National Cancer Institute, Bethesda. Research is focused on investigating the role of cytokines in inflammation, immunity, hematopoiesis and cancer.

Laboratory of Molecular Pharmacology (National Cancer Institute, USA) The laboratory conducts research into the relationships between molecular and cellular biology alterations involved in carcinogenesis. The Web site includes details of the project areas in the lab.

Laboratory of Tumor Immunology and Biology - NCI (USA) The Laboratory is located in Bethesda and is part of the NCI Division of Basic Sciences. It includes research teams in experimental oncology, oncogenetics, molecular and cellular endocrinology, tumor growth factors and cellular biochemistry.

McArdle Laboratory for Cancer Research (University of Wisconsin, Madison) The Laboratory and Department of Oncology were founded in 1940. The Web site includes details of basic research programs and laboratories.

Paterson Institute for Cancer Research (Manchester, UK) The Institute is part of the Christie Hospital NHS Trusts and is affiliated to Victoria and UMIST universities. The web site includes information about the Institute, its departments, endocrinology, free radical research, links etc.

University of Bradford Cancer Research Unit (UK) The Unit was founded in the mid 1970's and undertakes a range of research including the development of new anti cancer drugs. It is funded by the CRC/War on Cancer. The Web site includes details of the Unit, research, publications etc.

Reactive oxygen/nitrogen/chlorine radicals can damage DNA despite the antioxidant defence and repair systems of the body. DNA damage associated with free radicals is thought to make a significant contribution to the age-related development of cancer.
Factors such as diet can modulate oxidative DNA damage, particularly by vegetable intake via antioxidants such as vitamin C, alpha-tocopherol and beta-carotene.

International Society for Free Radical Research Founded in 1982 the society promotes interest in all aspects of research into the reactions and properties of free radicals. SFRR has 4 regional groups; Oxygen Society (Pan America), SFRR Asia, Europe and Australasia.

Oxygen Society, The A Pan American organisation founded in 1987 for those with a professional interest in free radical biology, chemistry, and medicine.

Packer Laboratory at the University of California (Berkley, USA) the lab specialises in research into how reactive oxidants are generated in biological systems, how redox-based antioxidants and other natural antioxidants respond to oxidative stress and how these processes modulate gene expression.

Reactive Oxygen Species Interest Group This is a Special Interest Group of the National Institutes of Health which is linked to the Oxygen Society. The Web page has details of meetings and contact information.

Society for Free Radical Research - Europe An international scientific society, founded in 1982, which is dedicated to promote interest in all aspects of research related to Free Radicals. The Web site includes details of membership, conferences, journals, and related links.