The effects of chlorpromazine, an inhibitor of both Ca2+ flux and phospholipase activity, on myocardial ultrastructure, function and metabolism were assessed during normothermic ischaemic cardiac arrest and reperfusion of ...

We describe a 29-year-old male, previously in good health, with no history of angina pectoris and no risk factors for ischemic heart disease presenting with biventricular failure and severe mitral valve regurgitation. There ...

The effects of coronary artery ligation on myocardial ultrastructure, high energy phosphate contents and mitochondrial oxidative phosphorylation were studied in the isolated, perfused working rat heart model. The changes ...

In this study incorporation of [3H]inositol into inositol phosphates and phosphoinositides as well as tissue Ins(1,4,5)P3 levels of the atria and ventricles of isolated, perfused rat hearts were compared. Although the ...

Congestive heart failure is a major problem in developed and developing countries alike. Primary dysfunction of the heart muscle accounts for a significant proportion of patients with a non-ischaemic cause of heart failure. ...

Involvement of the opioid receptors in preconditioning-induced protection has recently been described. The aims of this study were to establish whether: (i) opioid receptor stimulation acts as a trigger (during the ...

The hypothesis that inhibition of mitochondrial adenine nucleotide translocase activity by accumulation of long chain acyl-CoA esters might be responsible for the depression in mitochondrial energy metabolism in myocardial ...

Background: The last 50 years have seen major changes in the epidemiology of infective endocarditis (IE). Aim: To evaluate local patient characteristics, risk factors, clinical sequelae, microbiology, morbidity and mortality ...

Murmurs heard over the back in children with heart disease are usually thought to be caused by pulmonary stenosis and coarctation of the aorta. In this prospective study 59.6% of 104 children with various congenital and ...

Background: Exogenous insulin is known to protect against ischaemia-reperfusion injury of the myocardium. We investigated whether these benefits of insulin could be explained by increased glycolysis during the ishaemic ...

Autophagy is a conserved catabolic process for long-lived proteins and organelles and is primarily responsible for nonspecific degradation of redundant or faulty cell components. Although autophagy has been described as ...

Mitogen-activated protein kinase (MAPK) has recently emerged as a prominent role player in intracellular signalling in the ventricular myocyte with attention being focussed on its possible role in the development of ...