In Mitsuhide's story, Tragic Determination, he rebels against his master, deciding that Nobunaga has strayed too far off his path of uniting Ransei. Hearing from Ranmaru of Mitsuhide's betrayal, Nobunaga challenges Mitsuhide, daring him to defeat the entirety of his army before three years pass. Upon doing so, Nobunaga admits defeat, and asks Mitsuhide to do what he could not.

Trivia

Mitsuhide and Hideyoshi have special quotes when battling each other in a kingdom with banners. Their Pokémon also get maximum energy when the quotes are shown. This is probably a reference to the Battle of Yamazaki, after Akechi Mitsuhide betrayed and killed Oda Nobunaga.