The background process for the Nero PhotoShow Media Manager, this application starts with Windows once installed. It constantly monitors for external media being plugged in or multimedia files being accessed. Once detected, it launches the interface portion of Nero PhotoShow Express. PhotoShow Express is a digital picture and video program used for easy access and editing of your multimedia files. Part of the Nero Multimedia Suite, Nero produces a lineup of software that allows you to playback, create, encode, and more with numerous multimedia file types. Nero was first formed in 1995 in Karlsbad, Germany, as Ahead Software. Ahead Software changed its name to Nero AG in 2005.
If you want a detailed security rating about your mssysmgr.exe (and all other running background processes) read the following user opinions, and download the free trial version of Security Task Manager.

Note: Any malware can be named anything - so you should check where the files of the running processes are located on your disk.
If a "non-Microsoft" .exe file is located in the C:\Windows or C:\Windows\System32 folder, then there is a high risk for a virus, spyware, trojan or worm infection!
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Users Opinions

Average user rating of mssysmgr.exe:
based on 20 votes. Read also the 22 reviews.

227 users ask for this file.
11 users rated it as not dangerous.
One user rated it as not so dangerous.
4 users rated it as neutral.
4 users rated it as little bit dangerous.
4 users didn't rate it ("don't know").

PhotoShow is a piece of software that is part of the Nero Ultra Edition suite. See also: LinkDarrell

I inherited this file from Adobe Photoshop Album 2.0 Starter Edition, I shut down from Task Manager safely Soonerfan

It's part of PhotoShow Deluxe. It keeps track of changes in 'My Pictures' and pops up a dialog when a camera is connected See also: LinkQuint King

You can disable it by renameing it to mssysmgr.exe.old and there appear to be no effects whatsoever. Also, once disabled, if you remove he Run registry key for mssysmgr.exe, it will not be re-created since mssysmgr.exe was creating it after being launched. Cringer

I have PhotoShow Deluxe and it won't run properly. Have to close it with ctrl/alt/del. Says, "mssysmgr not responding" Victoria Gregor

it is part of walgreens photoshow jimp65

I've been having trouble with my win98 system freezing. Just before it happened the last time I looked at task manager and saw mssysmgr "not responding". I told task manager to shut it down, and it froze my system. Had not used PhotoShow Deluxe, but had viewed a slideshow on WebShots. Chip

I need to know how to fix it!! Shelley

On my comp it tells photos to upload to Walgreens Gillian

This file helps PhotoShow software keep track of pictures that have been added to folders specified by users. It does not take up much CPU power and runs in the background. Alex