Kevin Smith has cast his own daughter Harley Quinn and Johnny Depp's daughter Lily-Rose alongside Depp in his new comedy horror film "Yoga Hosers," a spinoff of sorts of Smith's upcoming horror film "Tusk," which hits theaters next month, according to the Hollywood Reporter.

"People always ask me 'Are you ever going to make a comic book movie?'" the Highlands native says in a statement. "This is it — but instead of yet another dude saving the day, our antiheroes are the most feared and formidable creatures man has ever encountered: two 15-year-old girls."

Both girls have cameos as convenience store workers — quite a departure for Smith — in "Tusk," and the rest of the cast, including Justin Long and Haley Joel Osment, will return for "Yoga Hosers." Also joining the cast: Tony Hale of "Veep," Natasha Lyonne of "Orange Is the New Black," and Smith regular Jason Mewes. "Yoga Hosers," part of the filmmaker's planned True North trilogy about Canadian myths, started shooting this week.

Harley Quinn Smith, left, and Lily-Rose Depp in "Tusk."

"Yoga Hosers" follows the two young yoga fanatics, both named Colleen, as they join forces with a "legendary man-hunter from Montreal" (Depp) to fight an ancient evil, "one Warrior Pose at a time," producers tells the Hollywood Reporter. Smith Tuesday tweeted the story, crediting fans for making these movies happen. "Sometimes, a little encouragement goes a LONG way."