Clinical response = Complete Response (absence of residual disease) or Partial Response defined as no new lesions (skin or oral), or no new visceral sites of involvement (or the appearance or worsening of tumor-associated edema or effusions); AND 50% or greater decrease in the number of lesions lasting for >4 weeks; OR Complete flattening of at least 50% of all previously raised lesions OR A 50% decrease in the sum of the products of the largest perpendicular diameters of the marker lesions

More than 60 days since prior local therapy to any KS indicator lesion unless the lesion has progressed since treatment

More than 4 weeks since prior investigational therapy for KS

More than 4 weeks since other prior therapy for KS

More than 14 days since prior acute treatment for an infection or other serious medical illness

No concurrent warfarin

No concurrent grapefruit juice

No other concurrent therapy for KS

No other concurrent investigational drugs

Concurrent antiretroviral therapy required except for patients who have exhausted all available treatment options

Contacts and Locations

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study.
To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below.
For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00090987

Locations

United States, California

Moores UCSD Cancer Center

La Jolla, California, United States, 92093-0658

USC/Norris Comprehensive Cancer Center and Hospital

Los Angeles, California, United States, 90089-9181

Jonsson Comprehensive Cancer Center at UCLA

Los Angeles, California, United States, 90095-1781

Desert Regional Medical Center Comprehensive Cancer Center

Palm Springs, California, United States, 92262

UCSF Comprehensive Cancer Center

San Francisco, California, United States, 94115

United States, Florida

University of Miami Sylvester Comprehensive Cancer Center - Miami

Miami, Florida, United States, 33136

United States, Illinois

Robert H. Lurie Comprehensive Cancer Center at Northwestern University