Focus Issue: Cellular Regulation Through Protein Interaction Domains

One of the major themes that has emerged in the last 15 years of research into mechanisms of cellular regulation has been the realization of the importance of protein interaction domains as distinct modules that function to determine the interaction partners of various signaling proteins. Understanding the properties of these domains is essential to understanding signaling, and the implications of this basic characteristic of signaling mechanisms are vast. A Review by Pawson and Nash in Science