They'll head on the road to play the Jets, Bills, Dolphins, Cleveland Browns, Pittsburgh Steelers, Arizona Cardinals, San Francisco 49ers and Denver Broncos.

The New England Patriots will open the 2016 NFL season on the road on a Sunday night against the Arizona Cardinals.

The Patriots home opener at Gillette Stadium will come in Week 2 vs. the Miami Dolphins.

They'll have a short turnaround, as they face the AFC South division champion Houston Texans on a Thursday night in Week 3.

In Week 4, on Oct. 2, the Patriots welcome the Buffalo Bills to Gillette Stadium for a Sunday Night Football matchup.

The Patriots travel to Cleveland in Week 5, on Oct. 9, to square off against the Browns on the road for the first time since 2010, a game the Patriots lost, 34-14. New England has not won in Cleveland since 2004.

Week 6 features a home matchup against the Cincinnati Bengals on Oct. 16.

The Patriots visit the Pittsburgh Steelers in Week 7, on Oct. 23, for the first time since 2011 in a matchup that will feature two quarterbacks – Tom Brady and Ben Roethlisberger – who have started nine of the last 15 Super Bowls combined.

The Patriots then travel to Buffalo to play the Bills in Week 8 on Oct. 30, ahead of their Week 9 Bye.

A slate of back-to-back road games starts with New England’s first trip to Levi’s Stadium in Week 11 on Nov. 20, to play the San Francisco 49ers.

The Patriots then travel to MetLife Stadium in Week 12, on Nov. 27, for their first of two matchups against the N.Y. Jets.

The Patriots return home for a Week 13 game, on Dec. 4, against the L.A. Rams.

Week 14 features New England’s lone Monday Night Football matchup of the season, when the Baltimore Ravens travel to Gillette Stadium on Dec. 12.

New England returns to Denver in Week 15 for the third time in two seasons to face the Broncos at Sports Authority Field at Mile High.

The Patriots close out the regular season with consecutive division games. Week 16 features a Christmas Eve matchup against the N.Y. Jets at Gillette Stadium.

New England then closes out the regular season for the second straight year with a trip to visit the Miami Dolphins at SunLife Stadium on Jan. 1.