Dr. Matthias Meier

Dr. Matthias Meier

My research group is focusing on the development and usage of large-scale microfluidic integration platforms for screening and characterization of biomolecular interactions within the regulatory network of the cell metabolism. In order to obtain a systems biology perspective we work on three different biological levels, i.e. the molecular, cellular and organism level. On the molecular level we envision the construction of protein interaction maps based on thermodynamics, kinetics structural parameters rather than only on binary interaction information. On the cellular and organismic level we aim to characterize the cell metabolism upon changing cell environments and simulate with help of microengineering approaches real world conditions. We emphasize our work on post-translational modifications and epigenetic factors acting on different timescales. Bringing together broad experimental protein interaction information from various biological levels and different biophysical angles we integrate information about the regulation of cell metabolism under various conditions including disease states in human and crop plants.