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Application Note: Best Practices for Crystallization Development

3 December 2012

Crystallization and precipitation are critical processing steps in chemical development. They can serve as purification and separation steps, and have implications on the yield, purity and particle size distribution. Even though crystallization has advanced significantly over the past decade, many chemists have such short deadlines that they must base everyday decisions on past experience rather than understanding the crystals in situ. This white paper from Mettler Toledo demonstrates the methodol¬ogy chemists use to identify operating parameters such as temperature, solvent addition rates and seeding to improve crystallization, batch repeatability, and crystal size and shape distribution.