BRONCHITIS and Metronidazole

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BRONCHITIS Symptoms and Causes

Bronchitis is an inflammation of the bronchial tubes, the airways that carry air to your lungs. It causes a cough that often brings up mucus. It can also cause shortness of breath, wheezing, a low fever, and chest tightness. There are two main types of Bronchitis: acute and chronic.

Most cases of acute Bronchitis get better within several days. But your cough can last for several weeks after the infection is gone.

The same viruses that cause colds and the flu often cause acute Bronchitis. These viruses spread through the air when people cough, or though physical contact (for example, on unwashed hands). Being exposed to tobacco smoke, air pollution, dusts, vapors, and fumes can also cause acute Bronchitis. Less often, bacteria can also cause acute Bronchitis.

To diagnose acute Bronchitis, your health care provider will ask about your symptoms and listen to your breathing. You may also have other tests.

Treatments include rest, fluids, and aspirin (for adults) or acetaminophen to treat fever. A humidifier or steam can also help. You may need inhaled medicine to open your airways if you are wheezing. Antibiotics won't help if the cause is viral. You may get antibiotics if the cause is bacterial.

BRONCHITIS Clinical Trials and Studies

Treatments might be new drugs or new combinations of drugs, new surgical procedures or devices, or new ways to use existing treatments. The goal of clinical trials is to determine if a new test or treatment works and is safe. Clinical trials can also look at other aspects of care, such as improving the quality of life for people with chronic illnesses. People participate in clinical trials for a variety of reasons. Healthy volunteers say they participate to help others and to contribute to moving science forward. Participants with an illness or disease also participate to help others, but also to possibly receive the newest treatment and to have the additional care and attention from the clinical trial staff.

the time to event (next Bronchitis episode) rate during and after treatment period; days and percentage of days without Bronchitis during and after treatment period; days and percentage of days without Bronchitis during treatment period

Measure and compare the sustained effects on mucus clearance of two weeks of daily dosing of hypertonic saline versus a low salt control treatment for subjects with CB.; We will also be collecting sputum and breath condensation to analyze for protein and inflammatory changes that might occur with exacerbations.

proportion of patients with exacerbations in each study group from week 0 to week 32.; the magnitude of the reduction in the dose of prednisone from week 12 to week 32.; change in % sputum eosinophil; Blood eosinophils; Forced Expired Volume in 1 second (FEV1); Ratio of Forced Expired Volume in 1 second to Forced Vital Capacity (FEV1/VC); Provocative concentration causing a 20% drop in FEV1 (PC20); Asthma Control Questionnaire; Fraction of exhaled nitric oxide (FeNO)

Percentage of patients presenting with haemoptysis affected by lung cancer, tuberculosis, bronchiectasis, pneumonia, acute Bronchitis, cryptogenic haemoptysis or other causes.; Sensitivity and specificity of chest X-ray, chest CT scan and bronchoscopy alone and in combination in the diagnosis of different causes of haemoptysis.; Percentage and severity of recurrence of haemoptysis in the follow-up period.; Sensitivity and specificity of bronchoscopy in localizing the bleeding side and lobe in relation to the timing of the haemoptysis.; Patient survival in the follow-up period.

If you think you may have a medical emergency, call your doctor or 911 immediately.

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