Reverse is an anti-aging and antioxidant blend like no others on the market. The Reverse formulation has two innovative, patent pending compounds that have been clinically shown to possess a myriad of properties which make for the most advanced over-the-counter health improvement product on the shelves. Reverse can literally “reverse” the deteriorative effects of stress and aging, actively defend against disease and infections, protect and maintain vital organs and cells in the body and improve the level of health of individuals at any stage in life. With all of the toxins and stress that you are exposed to each day, feel better in knowing that Reverse is here to help combat the forces working against the healthier, stronger, more vibrant you!

In recent years efforts have been made to isolate and identify a variety of biologically active compounds found in vegetable oils, olive oil, red wine, red/white must, fish and milk. These phenolic compounds are thought to be vital constituents in our diets and have shown to exert such dramatic health related benefits (many of which are still being discovered to date) that the necessity of daily intake should not be denied. One of the most important constituents found is Resveratrol (3,5,4’-trihydroxy-trans-stilbene), a phenolic compound found naturally such as grape skins, peanuts, blueberries, legumes, cranberries, and many other foods. Resveratrol has been shown to protect against free-radical oxidation, platelet aggregation and thrombus formation, and exhibits many other potentially life extending, protective and inhibitory properties. Hundreds of clinical studies have been conducted on resveratrol that provide significant evidence of these effects both in animal and human subjects.

Although Resveratrol is found in many different foods the concentration is still very small. Daily intake of even a large number of Resveratrol rich foods might not be enough to fully benefit from Resveratrol’s amazing effects. For instance red wine, known to be one of the most concentrated resveratrol rich products, has on average 5 milligrams per liter of red wine. At this rate you would need to drink 60 liters of red wine to get the same amount of resveratrol present in Reverse.

Many studies have isolated and characterized a number of highly important, bioactive, phenolic compounds (such as Resveratrol) and even though these molecules have very different origins and molecular skeletons, the majority of them all had various analogs that coexist in nature. Recently scientists have started analyzing these naturally occurring analogs to determine why it is they seem to be so biologically active and important. What they found was that among these analogs, acetylated phenolics exhibited a higher level of activity that is attributed to faster absorption and greater cellular uptake. The existence of these acetylated phenolic compounds in natural sources has been established in many recent studies and the comparative data is being studied extensively. So far the naturally occurring acetylated derivatives of Resveratrol have been identified in plants and specifically, triacetylated resveratrol, has been found in marine invertebrates.

The main drawback with current resveratrol forms is the low oral bioavailability. This low bioavailability is caused by the body’s natural defense to foreign substances, in which enzymes present naturally break down compounds so that they can be easily excreted. This is why finding these acetylated analogs has been so significant; they have better bioavailability and increased biological activity in comparison to the base phenolic compounds. Multiple studies have shown that acetylated analogs of Resveratrol exhibit the same or higher inhibitory effects on various tumor cell lines than Resveratrol itself while being absorbed faster and resisting cellular breakdown. Since the acetylated Resveratrol is being absorbed more quickly, plasma levels in the body reach a higher level and at a faster rate. Through ester hydrolysis enzymes in the body actually break down acetylated Resveratrol back to its natural phenolic form. This is what makes Reverse such an innovative product; you can essentially help Resveratrol resist breakdown and absorb faster yet still have it present in its natural form where it can exhibit all of its amazing benefits.

In recent years scientists have also been experimenting with other ways to get Resveratrol to absorb more rapidly. One method currently being studied is micronizing and complexing. Since Reverse contains a liquid capsule with a lipophilic solvent, the acetylated Resveratrol is completely dissolved, breaking down into very fine particles that are absorbed easier than larger particles found in some competitor capsules. One thing can be said for certain, there are no other Resveratrol products on the market that can begin to compare to the triacetylated Resveratrol found in the proprietary blend of Reverse.

Glutathionylcobalamin (Patent Pending)

The second key ingredient found in Reverse is a combination of glutathione and cobalamin (B12) that has been bonded to create the most superior available oral form of B12 and glutathione on the market. As a matter of fact, it has been shown to be more potent as an orally delivered than commonly prescribed injectable forms of B12. This compound trumps common B12 and glutathione supplementation bioavailability issues and utilizes the maximum capabilities of an oral supplement of this type.

There are 5 known “active” forms of cobalamin (B12): cyanocobalamin, hydroxycobalamin, adenosylcobalamin (Adeno-B12), glutathionylcobalamin (GS-B12), and methylcobalamin (methyl-B12). Cyanocobalamin is the most commonly supplemented form of B12, but you might be surprised to discover that this form of vitamin B12 does not actually occur in plants or animal tissues and has oral bioavailability and potency issues. Methyl-B12 and Adeno-B12 (made in the mitochondria) are the only two coenzyme forms of B12. The coenzyme form is already ready for use by the body, no other conversions are necessary. There is no need to take additional supplements or need for certain chemical reactions to take place in your body to be utilized effectively. Hydroxycobalamin (hydroxyl-B12) is a form of vitamin B12, which (like GS-B12) is more readily converted into the coenzyme forms than conventional cyanocobalamin. The hydroxyl-B12 is also known to interact with GS-B12 to form methyl-B12.

The remaining analogs of B12 have one thing in common; they essentially convert or need to convert to one of the “other” active forms of B12 to be of value. All forms of B12 currently available as pharmaceutical preparations (i.e. injection) first require conversion to GS-B12 to become a coenzyme form and also require glutathione for synthesis. GS-B12 does not have intermediate conversions and the unique part is it is carrying its necessary glutathione for the destination reactions. GS-B12 is also a known precursor to the methyl-B12 and adeno-B12 forms and it has been found that GS-B12 actually converts into these 2 coenzyme forms. This will combine the beneficial effects of all three in one. Even though research points to specific uses/benefits for the various existing analogs of B12; GS-B12 is clearly the most remarkable oral form.
Glutathione plays an important role in biosynthesis, metabolism, transport, the protection against and detoxifying of possibly harmful free radicals; it is a necessity for a number of chemical processes in the body and is critical for overall health. Glutathione has tremendous benefits as a neurological antioxidant and is key to many other neurologically dependent functions. Current available forms of glutathione have oral bioavailability issues resulting in poor blood plasma levels, which has always been a limitation in supplementing with this vital compound.
The supplementation of N-acetyl-cysteine (NAC) has been known to increase the effectiveness of regular B12 because it converts to glutathione in the body. With GS-B12 you will no longer need NAC to convert to glutathione and increase the effectiveness of B12 in the body. You are going directly to the source and the best part is that the glutathione will now be efficiently absorbed orally. With GS-B12 successful delivery and use of B12 and glutathione in the body can now be achieved.

Because of the use of GS-B12, Reverse, possesses all the best properties of B12, enables oral bioavailability of glutathione, eliminates the “middle men” of chemical synthesis and increases the levels of all 3 most desired analog forms of B12 in the body. Knowing this, which product would you chose?