The objective of this research was to evaluate the effect of probiotics supplementation of Lactobacillus sporogenes and Saccharomyces cerevisiae on the productive parameters in the commercial exploitation of guinea pigs in the commercial growth-fattening stage: initial weight, weight gain, feed conversion, food consumption. For this, 24 weaned guinea pigs of 15 days of age and 283.79 grams of average weight were used, line Peru. A completely randomized design was used, with three treatments and two repetitions. The treatments were: (T0) ordinary diet; (T1) ordinary diet + Saccharomyces cerevisiae, (T2) ordinary diet + Lactobacillus sporogenes. The results showed better final weight for the T0 (842.14 gr) over the T2 (778.00 gr) and T1 (768.50 gr), in terms of the weight gain in the same way the T0 (556.81 gr) showed better values than the T1 (497.33 gr) and that T2 (484.33 gr); the same occurred for the food consumption T0 (2417.67 gr) showed better values than the other two treatments T1 (2284.84 gr), T2 (2249.67 gr); and finally the feed conversion also obtained better results in T0 (5.83), T1 (6.48) and T2 (6.75). No statistically significant difference was observed in any of the treatments. It is concluded that there is no effect on the productive parameters of guinea pig breeding under the use of probiotics.