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Wiley

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The current study examined the relationship between plasma orexin-A and sleep in obesity. Concentrations of orex in-A and sleep were
evaluated in 26 obese, 40 morbid obe se and 32 healthy-weight participants. The ... [+]

The current study examined the relationship between plasma orexin-A and sleep in obesity. Concentrations of orex in-A and sleep were
evaluated in 26 obese, 40 morbid obe se and 32 healthy-weight participants. The sleep monitor Actiwatch AW7 and the Pittsburgh Sleep
Quality Index were used to evaluate sleep. The Symptom Checklist-90-Revised was administered to assess symptoms of psychopathology.
A higher weight status was associated with elevated orexin-A levels (p = .050), greater depression, anxiety and somatization symptoms (all:
p < .001), and impoverished self-reported sleep quality (p < .001). A quadratic trend was found in objective sleep time, being longest in the
obese group (p = .031). Structural equation modelling showed plasma orexin-A to be related to poor total sleep quality, which in turn was
associated with elevated body mass index. Our data conﬁrm an interaction between elevated plasma orexin-A concentrations and poor
sleep that contributes to ﬂuctuations in body mass index. [-]