List Of Drugs Contraindicated in Pregnancy

The rule about taking medicines during pregnancy is simple: Always ask your doctor first. That includes questions about prescription and over-the-counter (OTC) drugs. You should definitely not take some medicines. For others — the yellow flags — your doctor may need to weigh the risks and benefits to you and your baby. Here is a list of drugs contraindiacated in pregnancy and the side effects which occur due to using these medications:

(6)Sulfamethoxazole/trimethoprim (Bactrim) during 3rd trimester. May increase bilirubin levels leading to kernicterus.(7) Nitroimidazole, (Metronidazole and Tinidazole) during 1st trimester.(8) Griseofulvin:- May increased risk of spontaneous abortion.(9) Methotrexate:- Causes cleft palate along with multiple defects.(10) Estradiol:- Urogenital abnormalities in offspring that manifest later in life. May couse uterine cervix, vaginal and testicular cancer have developed later in life in offspring.

(11) Thalidomide:- Seal like limbs and other defects.(12) Clomiphene citrate:- Can cause birth defects.(13) Medroxyprogesterone acetate:- Can cause birth defects.(14) Vitamin A and its derivatives:- Birth defects, miscarriage.(15) Danazol:- Causes malformations in sex organs of female fetus.(16) Finasteride:- Even pregnant women should not handle broken or crushed tablets since it can get absorbed through the skin and affect the sexorgan development of the male fetus.

Category A; Adequate and well-controlled studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters).

Category B; Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.

Category C; Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

Category D; There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

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Category X; Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use of the drug in pregnant women clearly outweigh potential benefits.