For Once in My Life is a documentary about a unique band of singers and musicians, and their journey to show the world the greatness – and killer soundtrack – within each of them. The 28 band members have a wide range of mental and physical disabilities, as well as musical abilities that extend into ranges of pure genius. In a cinema vérite style, the film explores the struggles and triumphs, and the healing power of music, as the band members' unique talents are nurtured to challenge the world's perceptions.