According to Andriasang, Famitsu asked Nomura if Neku's appearance provided notice of a sequel to the Shibuya-based DS RPG. Nomura didn't quite confirm a sequel, but he did say that the appearance suggested "something" that Square Enix is working on.

Last year, Nomura said he wanted to make a sequel to TWEWY "when the time is right." Perhaps the time will be even closer to right two minutes from now, when you've watched the new trailer above (featuring Neku).