Computational laboratory: Starting from a set of breast cancer BACs (bacterial artificial chromosomes) End Sequence Profiling (ESP) is performed. ESP analysis sequences the ends of insert DNA in order to characterize genomic rearrangements that may be involved in breast cancer progression. In this study, genomic rearrangements are characterized from 100 breast cancer BACs and 10,000 Fosmids (derived from a pool of the 100 originating BAC) using ESP. Analysis and comparison of both BAC and...

The inception of the "Keeling Curve," a history of atmospheric carbon dioxide levels, marked a key moment in American science history. The record began in March, 1958 at a small observatory on the top of Hawaii's Mauna Loa.