Teen Girl Squad is a purposefully crudely drawn comic series, drawn on notebook paper, which centers around four stereotypical teenage girls' quest to become popular and to look "SO GOOD!", or so they say. Of course, they never appear to succeed due to being always on a different track. Its origins began in the Strong Bad Emailcomic, when a girl named Brittany asked Strong Bad to make a comic strip about her four friends. Strong Bad's spur-of-the-moment comic soon became a series of its own; the Brothers Chaps have also admitted to using it as an outlet for new female characters. In each issue, the blandly named girls — Cheerleader, So and So, What's Her Face, and The Ugly One — perform typical teenage activities, such as going to the mall, attracting cute boys, or babysitting, but Strong Bad's overactive imagination often subjects the girls to strange and gruesome deaths. Being killed doesn't seem to be a problem for the girls, however, as they always return for the next issue, or sometimes simply later in the episode. The two most popular gags in the series are the girls' catchphrase, "SO GOOD!", and the onomatopoeia used when a character dies — -'d, for example: "Lathe'd!", used to describe What's Her Face's being killed by spinning near a blade. Another common gag involves the girls exclaiming something in the format Ow! My X! to express pain in an unorthodox area, such as "my most of me" or "my style".

During the first three episodes of Strong Bad's Cool Game for Attractive People, Strong Bad makes some Teen Girl Squad comics. In the first two episodes, the comics are mini-games where your goal is to make Strong Bad laugh heartily to get the high score by killing all four girls during the course of the comics. You do this by using the correct items on the right girls during the right scenes. However some items are unavailable until Strong Bad finds the cards that provide additional ways to kill the girls.

Every episode has a different "description" of each girl on their title cards at the beginning. An extra set of these descriptions is also viewable in the preview of Teen Girl Squad on the TV Time Toons Menu, which can be seen by holding the cursor over the Teen Girl Squad button (swf file here). The descriptions tend to refer to Cheerleader's spoiled nature, So and So's book-smarts, What's Her Face's awkwardness or poverty, and The Ugly One's weirdness or lack of hygiene.

The AhnbergHand font used for Strong Bad's handwriting contains a few European-style slashes, including lowercase 'q' which The Brothers Chaps have been known to "Americanize". However, they have not altered the European seven in the current Teen Girl Squad main menu.

The page title (T33n G1rl Squ4dx0rx!!11) is Teen Girl Squadxorx!!!! in leetspeak.

So and So was originally referred to as Kristen in the first issue, with the name coming from the original suggestion. Shortly afterwards, though, she is called Kristina, making it clear that Strong Bad was already forgetting the names.

Different toons' back buttons link to different places. Teen Girl Squad issues 1-3, 8-10 and 13 link back to the Toons page while the rest links back to the Teen Girl Squad Menu.