Once named the Williamsburg of the West by Southern Living magazine, this Main Street region is Missouri's first and largest nationally registered historic district. Running parallel to the Missouri River, the brick-paved streets are home to one-of-a-kind shops, in restored buildings that date to the 1800s.

When you're ready for a break, you'll find ice cream and desserts; cafes and coffee houses; a winery; a microbrewery; a wide variety of restaurants; and a casino. (Some shops and all restaurants restrict pets, other than service animals.)

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