3-Methyl-2-phenylmorpholine
Molecular Weight

3-Methyl-2-phenylmorpholine
Melting Point

3-Methyl-2-phenylmorpholine
H2O Solubility

3-Methyl-2-phenylmorpholine
State

3-Methyl-2-phenylmorpholine
LogP

1.796

3-Methyl-2-phenylmorpholine
Dosage Forms

Tablet

3-Methyl-2-phenylmorpholine
Indication

Used as an anorectic in the treatment of obesity.

3-Methyl-2-phenylmorpholine
Pharmacology

Phenmetrazine is a sympathomimetic drug used primarily as an appetite depressant. Its actions and mechanisms are similar to dextroamphetamine. Amphetamines are non-catecholamine sympathomimetic amines with CNS stimulant activity. Phenmetrazine was originally sold under the tradename Preludin as an anorectic. It has since been removed from the market. It is by some considered to have a greater potential for addiction than the amphetamines, and has been abused in many countries, for example Sweden.

3-Methyl-2-phenylmorpholine
Absorption

Readily absorbed from the gastro-intestinal tract and buccal mucosa.

3-Methyl-2-phenylmorpholine
side effects and Toxicity

Adult monkeys have an LD50 of 15 to 20 mg/kg, whereas for young monkeys the LD50 is only 5 mg/kg. Symptoms of overdose include acute central nervous system stimulation, cardiotoxicity causing tachycardia, arrhythmias, hypertension, and cardiovascular collapse. Whilst some patients show signs of toxicity at blood concentrations of 20 µg/L, chronic abusers of amphetamine have been known to have blood concentration of up to 3000 µg/L.