Exploiting the Pleiotropic Antioxidant Effects of Established Drugs in Cardiovascular Disease Sebastian Steven, Thomas Münzel and Andreas Daiber Int. J. Mol. Sci. 2015, 16, 18185-18223; doi:10.3390/ijms160818185 Abstract: Cardiovascular disease is a leading cause of death and reduced quality of life worldwide. Arterial vessels are a primary target for endothelial dysfunction and atherosclerosis, which is accompanied or even driven by increased oxidative stress. Recent research in this field identified different sources of reactive oxygen and nitrogen species contributing to the pathogenesis of endothelial dysfunction. According to lessons from the past, improvement of endothelial function and prevention of cardiovascular disease by systemic, unspecific, ...