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BACKGROUND: Phaxan(TM) (PHAX, Chemic Labs, Canton, MA) is an aqueous solution of 10 mg/mL alphaxalone and 13% 7-sulfobutylether [beta]-cyclodextrin (betadex). In preclinical studies, PHAX is a fast onset-offset IV anesthetic like propofol, but causes less cardiovascular depression. This first-in-man study was designed to find the anesthetic dose of PHAX and to compare it with an equivalent dose of propofol for safety, efficacy, and quality of recovery from anesthesia and sedation.

The US Food and Drug Administration (FDA) has approved sugammadex injection (Bridion, Merck) for the reversal of moderate or deep neuromuscular blockade induced by rocuronium or vecuronium during surgery, according to an agency news release.

Washington—Anesthesia costs can differ by as much as 10-fold between similar cases, suggesting significant variability in how clinicians handle medications in the operating room, new research has found.

The wide variations in drug use, and consequent costs, among anesthesia providers during similar cases
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(Reuters) - The Food and Drug Administration will not complete its review of Merck & Co's experimental medicine to reverse the effects of anesthesia until the second half of 2013, representing a three-month delay, the drugmaker said.

Weevils floating in vials of heparin. Morphine cartridges that contain up to twice the labeled dose. Manufacturing plants with rusty tools, mold in production areas and — in one memorable case — a barrel of urine.

These recent quality lapses at big drug companies show that contamination and shoddy practices extend well beyond the loosely regulated compounding pharmacies that have attracted attention because of their link to an outbreak of meningitis.

Researchers are using sophisticated and powerful new tools to develop and evaluate new anesthetic agents with important advantages over current drugs, according to a set of papers in the August issue of Anesthesia & Analgesia, official journal of the International Anesthesia
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Transmission of life-threatening bacterial infections can occur when health-care personnel do not adhere to Standard Precautions and instead use medication in containers labeled as single-dose or single-use for more than one patient (1). This report summarizes the investigation of two outbreaks of invasive Staphylococcus aureus infection confirmed in 10 patients being treated for pain in outpatient clinics. In each outbreak, the use of single-dose or single-use vials (SDVs) for more than one patient was associated with infection
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