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Tending Bees for Winter Apitheripy

Does anybody have any experience collecting bees during the winter for the purpose of apitherapy? I'd like to set up a 4 frame observation hive indoors (with outdoor entrance) for my friend to collect bees from (approx. 20 bees a day) for his treatment during the long Canadian winter. I've never tried doing any kind of beekeeping during the winter.

Big questions:

How will indoor temperature warmth vs. outdoor chill affect the bees reproduction?
Will feeding be necessary? Will it stimulate the queen to lay? I imagine so.

Re: Tending Bees for Winter Apitheripy

I have an ob hive in my bedroom . The one with 5 frames below and a single frame above, like the one they sell at brushy mountain. I started it in July and they still have capped honey in the single frame above. I keep the room around 60 deg . I take bees out of the trap door on side all winter works great.
I modified the top a little so I could feed them if needed