Platinol

OVERDOSE

Caution should be exercised to prevent inadvertent
overdosage with PLATINOL.

Acute overdosage with this drug may result in kidney
failure, liver failure, deafness, ocular toxicity (including detachment of the
retina), significant myelosuppression, intractable nausea and vomiting and/or
neuritis. In addition, death can occur following overdosage.

No proven antidotes have been established for PLATINOL
overdosage. Hemodialysis, even when initiated four hours after the overdosage,
appears to have little effect on removing platinum from the body because of
PLATINOL's rapid and high degree of protein binding. Management of overdosage
should include general supportive measures to sustain the patient through any
period of toxicity that may occur.

CONTRAINDICATIONS

PLATINOL is contraindicated in patients with preexisting renal impairment. PLATINOL should not be employed in myelosuppressed patients,
or in patients with hearing impairment.

PLATINOL is contraindicated in patients with a history of
allergic reactions to PLATINOL or other platinum-containing compounds.

Last reviewed on RxList: 1/24/2012
This monograph has been modified to include the generic and brand name in many instances.