The present study was carried out to investigate traditional knowledge of ethno medicinal plants of District Charsadda, KP Pakistan. The local people of the area used surrounding natural resources that is wild plants for medicinal purposes and to cure different diseases. Due to poor condition of the modern health care facilities and poverty, indigenous people of the district partially depend on local medicinal plants. The present studies mainly focus on the information regarding indigenous uses of plants for medicinal purposes. The interviews were carried out in local community to investigate local people and knowledgeable persons (Hakims, Women and Heerdsmen) who are the main user of medicinal plants. The first investigation revealed a total of 60 plants species belonging to 34 families. The dominant families were found to be Asteraceae, Poaceae, Solanaceae which represented 6, 5 and 4 species respectively. The study area was visited frequently during flowering and fruiting seasons of plants in 2014. Plants were collected from a range of localities, identified, preserved and deposited with Herbarium of Hazara University, Mansehra.