Tuesday, January 20, 2009

Researchers at the University of California, Davis School of Veterinary Medicine have identified a gene mutation that causes high levels of uric acid and bladder stones in Dalmatians.

Elevated levels of uric acid is a trait found in all Dalmatians; other dog breeds do not usually product uric acid, according to the university. These high levels can cause bladder stones that often have to be surgically removed.

With this finding, dog breeders may be able to eliminate this trait.

"This defect, which in dogs is peculiar to the entire Dalmatian breed, has been reported for nearly a century and was probably unintentionally introduced as breeders worked to select more distinctive spotting patters," said Danika Bannasch, DVM, Ph.D., lead author on the study.

"It is now possible that this trait can be removed from the breed by crossing Dalmatians with the normal offspring of the original Dalmatian-pointer breeding that occurred in the early 1970s," she said.

The school's Veterinary Genetics Laboratory will being offering DNA testing for the mutation in dogs by Dec. 1st. For details, visit www.vgl.ucdavis.edu.

The discovery will also help scientists better understand the related problem in humans. Elevated levels of uric acid in humans can result in kidney stones, hypertension, and gout, and inflammation of the joints.

The Nov. 7 study published in the scientific journal Public Library of Science was supported, in part, by a fellowship from the Morris Animal Foundation and the National Institute of Diabetes and Digestive and Kidney Diseases within the National Institutes of Health.

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