Not sure if you are asking about modifying them from a LabVIEW application or settings dialogs. Also not sure if you are asking about a physical keyboard layout (assumed in the reply below) or a touch screen virtual keyboard.

If you just want to manually set them:

You can set the timezone in "Measurment & Automation Explorer". See the "Time Settings" tab when you click on a target. There are ways to do this programmatically too.

Setting the keyboard layout at the moment is a target only option: look under the "Settings->Keyboard" dialog. You can also do this programmatically via the System Exec vi or from a terminal. For example you can use the 'xfconf-query' utility to see/change the current keyboard layouts: xfconf-query -c keyboard-layout -p /Default/XkbLayout