Silene thurberi is a rare, coarse, scabrous, and viscid herb with small, inconspicuous flowers on elongate pseudoracemes or open dichasia. The veins on the small calyces are usually green and conspicuously broaden into the recurved teeth. It is more common in Mexico.

Silene rectiramea is very similar but differs in its somewhat smaller calyx; short, ovate calyx lobes; and entire corolla appendages.