Coexpression

Proteins whose genes are observed to be correlated in expression, across a large number of experiments.

STRING allows inspection of the interaction evidence for any given network. Choose any of the viewers above (disabled if not applicable in your network).

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:query proteins and first shell of interactors

white nodes:second shell of interactors

Node Content

empty nodes:proteins of unknown 3D structure

filled nodes:some 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

kamE

D-lysine 5,6-aminomutase subunit beta (263 aa)

Predicted Functional Partners:

kamD

D-lysine 5,6-aminomutase subunit alpha (523 aa)

0.998

PG_1069

Zinc-containing alcohol dehydrogenase (347 aa)

0.981

PG_1071

Hypothetical protein (322 aa)

0.963

PG_1072

MutS family protein (463 aa)

0.960

kamA

L-lysine 2,3-aminomutase (416 aa)

0.953

PG_1067

Hypothetical protein (129 aa)

0.899

PG_1075

Coenzyme A transferase subunit beta (220 aa)

0.848

PG_1068

Hypothetical protein (273 aa)

0.814

metK

S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme (429 aa)