Preheat broiler. Line broiling pan with aluminum foil.
Rinse tilapia. Pat fillets dry with paper towels. Season with salt, pepper and oregano. Add garlic, drizzle with oil and sprinkle bread crumbs on top.
Arrange fillets in a single layer on the prepared pan. Broil about 8 inches from the heat until the topping is browned. Be careful not to over cook the fish.
Serve with lime and your favorite vegetables.