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(Beyond Pesticides, January 25, 2017) A study conducted at the University of Buffalo recently revealed a connection between two common insecticides and an increased risk for certain metabolic diseases, including diabetes. Researchers found that by binding to and disrupting melatonin receptors that control numerous physiological functions, chemicals such as insecticides can affect melatonin levels, creating a higher risk for metabolic diseases to develop. The study, Carbamate Insecticides Target Human Melatonin Receptors, was published in Chemical Research in Toxicology and was funded by a grant from the National Institute of Environmental Health Sciences, which is part of the National Institutes of Health. The implicated chemicals in this research, carbaryl and carbofuran, are notoriously dangerous carbamate insecticides. Carbamates share structural characteristics and an ability to inhibit acetylcholinesterase (AChE), an enzyme important for the transmission of nerve impulses. When AChE is inhibited, acetylcholine accumulates leading to overstimulation of neurotransmitters, resulting in muscle weakness, confusion, and paralysis, among other symptoms. Carbaryl is said by EPA to be “one of the most widely applied insecticides in the U.S.,” since use began in 1959, with 10-15 million pounds used annually. It is a broad-spectrum insecticide used on a variety of crops, in forestry and on ornamentals, in […]

(Beyond Pesticides, October 20, 2016) Researchers at the University of Western Australia (UWA) and Murdoch University recently released a study whose findings show that levels of pesticides in breast milk have dropped significantly over the past forty years, though some major concerns remain. Published in the international journal Chemosphere, the research shows a 42-fold decrease in levels of pesticides detected in breast milk, and ties the reduction to government efforts to prohibit persistent organic pollutants (POPs) in Australia, which has lead to decreased exposure over time. Led by UWA’s internationally renowned human lactation researcher Emeritus Professor Peter Hartmann, Dr. Donna Geddes and Murdoch’s Associate Professor Robert Trengove, the study is a testament to the positive impact banning pesticides can have on the health of individuals, especially vulnerable populations like infants, but also shows that there is a long way to go before our bodies are void of any bioaccumulated toxic residues. Researchers often study breast milk because it can bioconcentrate, or accumulate, persistent organic pollutants (POPs). Multiple studies on breast milk have been performed throughout the years, many of them confirming the fact that common toxic chemicals, such as glyphosate and triclosan, build up in our bodies over time. Most […]

(Beyond Pesticides, July 19, 2016) Exposure to common pesticides at levels often found in the environment can have subtle but significant impacts on the behavioral health of fish, amphibians and other aquatic invertebrates. According to researchers at Northern Arizona University, who analyzed data from nearly 40 experiments to reach their conclusion, fish and amphibians swam 35% slower and were 72% less active after pesticide exposure. Chemical Class Type Example Pesticides Carbamates Insecticide Carbaryl, Aldicarb Organochlorine Insecticide DDT, Endosulfan, Chlordane Organophosphates Insecticide Diazinon, Chlorpyrifos Organotins Biocide Tributyltin Phosphonoglycines Herbicide Glyphosate, Glufosinate Pyrethroids Insecticide Permethrin, Bifenthrin, Esfenvalerate Triazines Herbicide Atrazine, Simazine The study, published in Science of the Total Environment, found that the overall effect on aquatic wildlife varied based on the chemical class the animals encountered. While pyrethroids, carbamates, and organophosphates resulted in a significant decrease in swim speed, triazines and phosphonoglycines showed no overall effect. Pyrethroids, carbamates, organophosphates, organochlorines, and organotins decreased activity, while phosphonoglycines had no overall effect, and triazines actually increased activity. “I didn’t think that we would see [an effect] across such a wide range of pesticides so consistently, but we did,” said study co-author, Catherine Propper, PhD to KNAU, “and that leads to some concerns about […]

(Beyond Pesticides, July 8, 2015) Last week, after decades of review and known toxic hazards, especially to children, the Environmental Protection Agency (EPA) accepted a proposed cancellation for a number of indoor uses (including food establishments) and tolerances of propoxur, a carbamate insecticide known for its toxic effects to children. EPA has received a Section 6(f) request under the Federal Insecticide, Fungicide and Rodenticide Act (FIFRA) from the registrant of propoxur to voluntarily cancel certain uses of the carbamate insecticide. The request from the manufacturer, Wellmark International, requests cancellation of indoor aerosol, spray and liquid formulations of propoxur, indoor crack and crevice use, and all use in food-handling establishments. EPA previously agreed to an April 1, 2016 phase out of propoxur in pet collars, but has continued to leave open these other avenues of exposure. The agency will begin accepting comments on its proposal once it has been published in the Federal Register, which is expected to occur within 10 days of the prepublication signature date. It should be noted that EPA engages in lengthy negotiations with pesticide manufacturers, as is the case with propoxur (see recent announcement on chlorpyrifos), rather than pursuing rigorous regulatory standards through its cancellation or […]

(Beyond Pesticides, July 29, 2013) Researchers at the U.S. Department of Agriculture (USDA) and University of Maryland have found that low levels of pesticide exposure from crop pollination make honey bees more susceptible to the deadly gut parasite, Nosema ceranae, contributing to declines in bee populations. The study’s findings, released Wednesday July 24 in the journal PLoSONE, expand on a recent report released by the USDA that found parasites, disease, genetics, poor nutrition, and pesticide exposure as synergistic factors in the observable nationwide honey bee decline, but focused on technological stopgap measures without questioning the sustainability of widespread systemic neonicotinoid pesticide use. Adding urgency to USDA’s research, another study released just last Monday in the Proceedings from the National Academy of Sciences shows that pollinator losses can have a detrimental effects on plant reproduction. Pesticide Exposure and Susceptibility to Disease The newest USDA research adds to the growing body of evidence that shows pesticide exposure weakens honey bees’ immune system making them more susceptible to parasites and pathogens. Researchers took pollen samples from crops that honey bees are known to pollinate including apples, watermelons, pumpkins, cucumbers, blueberries, and cranberries to determine exposure levels and Nosema infection. In sum, researchers found […]

(Beyond Pesticides, March 29, 2013) Two studies released Wednesday support the findings of the European Food Safety Authority that neonicotinoid insecticides pose an unacceptable risk to bees. The pair of British studies indicate that neonicotinoids and miticides cause brain damage, compromising bee survival. The study, published in Nature Communications by researchers at the University of Dundee and Newcastle University, concludes that imidacloprid and clothianidin, a commonly used insecticides on crops and plants, as well as the organophosphate miticide coumaphos, a treatment for Varroa bee mites, cause cognitive damage in bees. The research indicates that within 20 minutes of exposure to pesticides the neurons in the learning center of the brain stop firing, causing “epileptic type” hyperactivity. While the bees are still alive, the lobes of the brain fail to communicate with each other with obvious implications for their survival, Another study, published in the Journal for Experimental Biology by a team of Newcastle scientists, links imidacloprid and coumaphos to learning and memory impairment. The research indicates that brain damage from pesticides makes it more difficult for bees to forage and find food, and when they find the food they have trouble locating and returning to their hives. In sum, the […]

(Beyond Pesticides, February 26, 2013) The world’s most commonly used synthetic insect repellent is not as effective as it once was, according to scientists at the London School of Hygiene and Tropical Medicine. While researchers found DEET to be an effective repellent after an initial application, subsequent rounds of testing mere hours later showed mosquitoes to be unaffected by its presence. The study, published in the journal PLOS One, underlines the need to develop safe, natural, effective alternative preventions to this hazardous chemical. To perform their experiment, researchers took the mosquito species Aedes aegypti, a carrier for dengue and yellow fever, and exposed it to a human arm covered in DEET. A few hours later they repeated the experiment, but this time the mosquitoes largely ignored the presence of the chemical. To find out what caused this to occur, researchers placed electrodes on the antennas of the insects. “We were able to record the response of the receptors on the antenna to DEET, and what we found was the mosquitoes were no longer as sensitive to the chemical, so they weren’t picking it up as well,” co-author James Logan, PhD told the BBC. “There is something about being exposed […]

(Beyond Pesticides, May 17, 2012) Rather than investing in safe, long-term solutions to prevent malaria mortality, the World Health Organization (WHO) has issued a strategic plan that calls for multiple toxic pesticides to combat mosquito resistance to insecticides that is showing up in sub-Saharan Africa. Insecticide resistance, according to the WHO report, is already rampant in 64 malaria-ridden countries and may result in as many as 26 million more cases of malaria a year, which could end up costing between $30 and $60 million annually for tests and medication. Mosquitoes in sub-Saharan African countries are becoming resistant to pyrethroid insecticides, which are used extensively for household spraying and treating bed nets, as well as to the organochloride compound DDT -which is still used in many parts of the world to control mosquitoes. In Somalia, Sudan and Turkey, resistance has spread to carbamates and organophosphates in addition to pyrethroids and organochloride pesticides. Rather than reducing the reliance on these products, WHO is recommending rotating classes of pesticides used to spray inside homes and developing a new non-pyrethroid insecticide to treat bed nets. Implementation for these suggestions are estimated to cost around $200 million, which is in addition to the $6 billion […]

(Beyond Pesticides, April 13, 2012) A study has found that the children of flower plantation workers in Ecuador are neurologically affected by the pesticide residues that their parents unwittingly carry home on their clothes, tools, and skin. The study documents significantly reduced activity for the essential enzyme acetycholinesterase (AChE) in children whose parents work on flower plantations compared to others whose parents do not. The two main classes of pesticides that the researchers identify as used in the region’s flower production, organophosphates and carbamates, are known to suppress the enzyme’s activity. AChE activity is crucial to healthy neurological functioning in humans and its suppression during childhood can hinder nervous system and cognitive development causing immediate and long-term impairment. In the study, Lower acetylcholinesterase activity among children living with flower plantation workers (Environ Res. 2012 Apr;114:53-9. Epub 2012 Mar 10), children whose parents work on a flower plantation are more than three times more likely to be in the group of lowest AChE activity. Additionally, the children who live the longest with a flower plantation worker are four times more likely to have lower enzyme activity than children who never live with a plantation worker. The researchers obtained their results by […]

(Beyond Pesticides, October 28, 2010) In an effort to combat a bedbug problem in a Brooklyn, New York elementary school, the Department of Education (DOE) paid a private contractor almost $100,000 to exterminate and, according to teachers, left the classrooms “soaked with a liquid bed bug killing chemical.” An odorous fluid was left behind on children’s and teacher’s desks, books and on the floors. ABC 7 Online reports the unknown pesticide substance is being tested, but teachers and parents will not know the results and what they were exposed to for another two weeks. The teacher’s union estimates that cleaning up the classroom will cost over twice what was paid, and the DOE plans to bill the contractor and stop the company from future business in the city, according to the news report. This story showcases the importance of a comprehensive school and community pesticide and pest management policy in response to the mass hysteria that bedbugs are causing and as a general public health protection measure. The bedbug outbreak prompted the U.S. Environmental Protection Agency (EPA) to issue warnings against improper treatments and misuses of pesticides. Despite the fact that bed bugs do not transmit diseases and are not […]

(Beyond Pesticides, September 14, 2010) A new study confirms that indoor uses of consumer products, including pesticides, are the primary sources of indoor exposure to endocrine disruptors —chemicals that disrupt hormones and cause adverse developmental, disease, and reproductive problems— and shows that indoor levels are higher than those outdoors. Researchers from Silent Spring Institute, Columbia University, and the University of California-Berkeley measured airborne concentrations of endocrine disruptors in two California communities: Bolinas, a rural, affluent coastal town, and Richmond, a working-class city ringed by oil refineries. The study is published online in the September 1, 2010 issue of Environmental Science & Technology. The researchers analyzed 104 chemicals in 50 homes, including both chemicals that penetrate indoors from outdoor industrial and transportation sources and those from indoor use of consumer products and building materials. Similar levels of contamination were found inside homes in both communities, but outdoor levels were higher in Richmond. Among the chemicals found were pesticides, phthalates, parabens, PBDE flame retardants, and PCBs. A total of 38 pesticides are evaluated, including banned organochlorines (e.g., DDT, PCP), and current use products such as carbamates (e.g., propoxur), organophosphates (e.g., chlorpyrifos), and pyrethroids (cypermethrin). Thirteen pesticides were detected outdoors and sixteen pesticides […]

(Beyond Pesticides, July 29, 2010) A set of mandatory rules intended to reduce pesticide use in public and private schools in Indiana is pending approval after voluntary implementation guidelines failed. The Indiana Pesticides Board submitted a draft proposal in June outlining rules to minimize pesticide exposure to students. These measures include banning the use of pesticides when students are present, keeping pesticides locked in storage areas where students do not have access, providing advance notice of pesticide applications, and using pesticides with the lowest hazards to children. Although Beyond Pesticides recommend the additional step of developing a defined Integrated Pest Management (IPM) program, these tactics represent a good first step towards pesticide reduction in schools. The Indiana School Board Association developed a set of voluntary pesticide guidelines in 2001, but while rates of adoption increased, the Indiana state chemist’s office found that some schools were not implementing those policies, or had not adopted pesticide guidelines. It is important that schools adopt a comprehensive pesticide policy because children are especially vulnerable to the health hazards associated with pesticide exposure due to their small size, greater intake of air and food relative to body weight, and developing organ systems. Several pesticides, including […]

(Beyond Pesticides, June 17, 2010) Researchers have found detectable levels of common household pesticides in the majority of umbilical cord blood of babies born at an urban hospital. The study looks at concentrations of organophosphate (OP), carbamate, pyrethroids, and organochlorine pesticides in samples of umbilical cord blood taken from newborns delivered at the Johns Hopkins Hospital Labor and Delivery Suite in Baltimore. Researchers looked at the umbilical cord serum, as opposed to maternal serum, in order to provide a more direct estimate of exposure to the fetus. While human biomonitoring studies have found detectable levels of these pesticide chemicals in urine and blood samples from children and adults in the past, few studies have been carried out in the U.S. evaluating exposure in utero. In addition to tracking pesticide concentrations, researchers also aimed to identify demographic and socioeconomics factors associated with in utero pesticide exposure. Anonymous anthropometric and sociodemographic characteristics of the mothers and infants were collected along with umbilical cord blood that would have otherwise been discarded. Included in the characteristics collected that researchers considered might affect pesticide exposure risk were: age, race, body mass index, parity, education, health insurance, marital status, smoking, area of residence and housing density. […]

(Beyond Pesticides, March 29, 2010) Prenatal exposure to pesticides at levels that do not cause adverse health effects in the mother can lead to delayed brain developmental in the child, according to the new study, “Neurobehavioral Deficits and Increased Blood Pressure in School-Age Children Prenatally Exposed to Pesticides,” published last month in the early online edition of the journal Environmental Health Perspectives. Many pesticides are suspected of being capable of damaging the nervous system, in particular the development of a child’s brain during pregnancy and the early postnatal years of life. Now an international research team led by Philippe Grandjean, M.D., from the University of Southern Denmark and Harvard School of Public Health, has shown a delayed brain development up to two years in school children, whose mothers worked in a greenhouse during pregnancy. The exposed children also had increased blood pressure, while the mothers do not suffered adverse symptoms themselves. “The results support the notion that, in this cohort of children, prenatal exposures to pesticides are more harmful than current exposures, thereby confirming previous results of other environmental studies of neurodevelopmental toxicity and the theory of window of vulnerability of central nervous system during uterine life,” write the authors. […]

(Beyond Pesticides, January, 21, 2009) A new study concludes that exposures during pregnancy and childhood to insecticides that target the nervous system, such as organophosphates (OPs) and carbamates, are associated with childhood brain tumors. The researchers hypothesize that this susceptibility might be increased in children with genetic variations that affect the metabolism of these chemicals. The study, “Childhood Brain Tumors, Residential Insecticide Exposure, and Pesticide Metabolism Genes,” examines whether childhood brain tumors (CBT) are associated with the functional genetic variations. The study provides evidence that exposure to insecticides, paired with specific metabolism gene variants, may increase the risk of CBT. DNA was extracted from archival screening samples for 201 cases â‰¤ 10 years of age and born in California or Washington State between 1978 and 1990. Insecticide exposures during pregnancy and childhood were classified based on interviews with participants’ mothers. The children’s mothers reported whether they or anyone else had chemically treated the child’s home for insects including termites, fleas, ants, cockroaches, silverfish, or “other” pests. The results are consistent with the possibility that children with a reduced ability to metabolize organophosphate and carbamate insecticides might be at increased risk of CBT when sufficiently exposed. The researchers observed multiplicative interactions […]

(Beyond Pesticides, August 12, 2009) A new study examining the effects of the mosquito repellent DEET on insects, mice and human proteins reports that the chemical interferes with a prominent central nervous system enzyme. This effect is magnified when exposure to DEET is combined with exposure to certain other pesticides. Entitled, “Evidence for inhibition of cholinesterases in insect and mammalian nervous systems by the insect repellent deet,” and published in BioMed Central (BMC) Biology, the study utilized toxicological, biochemical and electrophysiological techniques to show that DEET is not simply a behavior-modifying chemical, but that it also inhibits cholinesterase activity in both insect and mammalian neuronal preparations. The researchers examined DEET’s effects on mosquitoes, cockroach nerves, mouse muscles, and enzymes purified from fruit flies and humans. Applications of DEET slowed or halted the actions of the enzyme acetylcholinesterase. This enzyme is crucial for regulating nerve impulses in both insects and mammals, and once its functions are disrupted, neuromuscular paralysis, leading to death by asphyxiation result. In humans, symptoms include headache, exhaustion and mental confusion together with blurred vision, salivation, chest tightness, and muscle twitching and abdominal cramps. The study also investigated the consequences of DEET interactions with carbamate insecticides on the […]

(Beyond Pesticides, March 5, 2009) A new study published in the March 2009 issue of Environmental Health Perspectives finds that pesticide combinations cause more harm to endangered salmon than ndividual pesticide exposure. This means that single-pesticide risk assessments required by the Environmental Protection Agency (EPA) inadequately assess hazards. Mixtures of organophosphate and carbamate pesticides are commonly detected in freshwater habitats that support threatened and endangered species of Pacific salmon. According to the researchers from the National Oceanic and Atmospheric Administration (NOAA) Fisheries and Washington State University, these pesticides inhibit the activity of acetylcholinesterase (AChE) and thus have potential to interfere with behaviors that may be essential for salmon survival. The researchers measured brain AChE inhibition in juvenile coho salmon exposed to sublethal concentrations of the organophosphates diazinon, malathion, and chlorpyrifos, as well as the carbamates carbaryl and carbofuran. The pesticides were tested individually and in combination. They plotted AChE levels on a curve to determine whether the toxicologic responses to binary mixtures were additive, antagonistic (lesser than additive) effect, or synergistic (greater than additive). The authors observed addition and synergism, with a greater degree of synergism at higher exposure concentrations. Several combinations of organophosphates were lethal at concentrations that were […]

(Beyond Pesticides, December 1, 2008) A new study by researchers at the University of California Los Angeles finds chronic exposure to commonly used dithiocarbamate fungicides, such as ziram, contribute to the development of Parkinson’s disease. According to the study, Ziram Causes Dopaminergic Cell Damage by Inhibiting E1 Ligase of the Proteasome, published in the Journal of Biological Chemistry, researchers screened several pesticides for their ability to interfere with the ubiquitin-proteasome system (UPS). Impaired UPS activity is reported in Parkinson’s disease patients’ brains. The researchers then focused on dithiocarbamate fungicides because they were found to be one of the most potent UPS inhibitors and are commonly used. The researchers discovered the mechanisms by which the UPS is impaired, showing that ziram and structurally related dithiocarbamates inhibit E1 ligase (a protein activating enzyme). Ziram is also found to increase alpha-synuclein (a protein expressed in the central nervous system) levels and selectively damages dopaminergic neurons in vitro. The study also cites unpublished data from a population-based study in central California that is determining pesticide exposure using state application registry, finding that individuals living within 500 meters of where ziram is applied are at three times the increased risk of developing Parkinson’s compared to […]

(Beyond Pesticides, November 18, 2008) At least one in four of the 697,000 U.S. veterans of the 1991 Gulf War suffer from Gulf War illness, a condition caused by exposure to toxic chemicals, including pesticides and a drug administered to protect troops against nerve gas, and no effective treatments have yet been found, a federal panel of scientific experts and veterans concludes in a landmark report released November 17, 2008. The Congressionally-mandated Research Advisory Committee on Gulf War Veterans’ Illnesses presented the report to Secretary of Veterans Affairs James Peake at Veterans Administration (VA) headquarters in Washington, DC. Scientific staff support to the Committee is provided by the Boston University School of Public Health (BUSPH). “The extensive body of scientific research now available consistently indicates that Gulf War illness is real, that it is the result of neurotoxic exposures during Gulf War deployment, and that few veterans have recovered or substantially improved with time,” the report says. The 450-page report brings together for the first time the full range of scientific research and government investigations on Gulf War illness and officially resolves many questions about the condition. The report found that Gulf War illness fundamentally differs from stress-related syndromes described […]

(Beyond Pesticides, March 13, 2008) Exposure to certain chemicals, including pesticides and nerve agents, explains the high rates of illness in Persian Gulf War Veterans, according to a new study published in the Proceedings of the National Academy of Sciences. Veterans from the 1990-91 conflict have a higher rate of chronic, multi-symptom health problems than either non-deployed personnel or those deployed elsewhere. Symptoms routinely reported by these veterans include fatigue, muscle or joint pain, memory problems, trouble sleeping, rash and breathing problems. Due to the findings, the study author, Beatrice Golomb, M.D., Ph.D., associate professor of medicine at the University of California, San Diego School of Medicine, warns of the potential risk to civilians exposed to pesticides.“Health issues among Gulf War veterans have been a concern for nearly two decades. Now, enough studies have been conducted, and results shared, to be able to say with considerable confidence that there is a link between chemical exposure and chronic, multi-symptom health problems,” said Dr. Golomb. “Furthermore, the same chemicals affecting Gulf War veterans may be involved in similar cases of unexplained, multi-symptom health problems in the general population.”The study synthesized evidence regarding a class of chemicals known as acetylcholinesterase inhibitors (AchEs), including […]

(Beyond Pesticides, April 30, 2007) Today, school officials, teachers, parents and community activists around the country are celebrating National Healthy Schools Day. The Healthy Schools Network, which organizes the event, and event supporters, including Beyond Pesticides, believe that every child in every community should have an environmentally safe and healthy school that is clean and in good repair. Schools in poor condition on the outside often have indoor environmental problems that affect children’s health and learning. Children face unique hazards from pesticide and other toxic chemical exposure. They take in more pesticides relative to their body weight than adults in the food they eat and air they breathe. Their developing organ systems often make them more sensitive to toxic exposure. The U.S. EPA, National Academy of Sciences, and American Public Health Association, among others, have voiced concerns about the danger that pesticides pose to children. The body of evidence in scientific literature shows that pesticide exposure can adversely affect a child’s neurological, respiratory, immune, and endocrine system, even at low levels. Several pesticides, such as pyrethrins and pyrethroids, organophosphates and carbamates, are also known to cause or exacerbate asthma symptoms. Buildings in disrepair typically face higher rates of pest infestation […]