Understanding mitochondrial pathophysiology and identifying ways to ameliorate mitochondrial dysfunction is are critical to therapy for cardiovascular disease. The objectives of this meeting are: 1) To mechanistically connect the fundamental biology of metabolism and mitochondrial function with the pathogenesis of heart failure, a major cause of morbidity and mortality in the world; and 2) To increase basic understanding of metabolism and mitochondrial function using observations in cardiac muscle, a traditional platform for these studies. Running in parallel with a meeting on “Diabetes and Metabolic Dysfunction,” the meeting will examine metabolism, mitochondrial function and heart failure in an integrated context and in the depth required to critically examine existing paradigms.