Form 8.3 - ABBVIE INC

A PERSON WITH INTERESTS IN RELEVANT SECURITIES REPRESENTING 1% OR MORE

Rule 8.3 of the Takeover Code (the “Code”)

1. KEY INFORMATION

(a)

Identity of the person whose positions/dealings

Barclays PLC.

are being disclosed:

(b)

Owner or controller of interest and short

positions disclosed, if different from 1(a):

(c)

Name of offeror/offeree in relation to whose

ABBVIE INC

relevant securities this form relates:

(d)

If an exempt fund manager connected with an

offeror/offeree, state this and specify identity of

offeror/offeree:

(e)

Date position held/dealing undertaken:

27 August 2014

(f)

Has the discloser previously disclosed, or are

YES:

they today disclosing, under the Code in respect

SHIRE PLC

of any other party to this offer?

2. POSITIONS OF THE PERSON MAKING THE DISCLOSURE

(a) Interests and short positions in the relevant securities of the
offeror or offeree to which the disclosure relates following the dealing
(if any)

Class of relevant security:

ORD

Interests

Short Positions

Number

(%)

Number

(%)

(1)

Relevant securities owned

and/or controlled:

3,280,168

0.21%

4,079,682

0.26%

(2)

Derivatives (other than

options):

3,380,250

0.21%

0

0.00%

(3)

Options and agreements to

purchase/sell:

6,408,300

0.40%

7,578,200

0.48%

TOTAL:

13,068,718

0.82%

11,657,882

0.73%

All interests and all short positions should be disclosed.

Details of any open derivative or option positions, or agreements to
purchase or sell relevant securities, should be given on a Supplemental
Form 8 (Open Positions).

(b) Rights to subscribe for new securities (including directors’ and
other executive options)

Class of relevant security in relation to which subscription right
exists:

Details, including nature of the rights concerned and relevant
percentages:

If there are positions or rights to subscribe to disclose in more than
one class of relevant securities of the offeror or offeree named in
1(c), copy table 2(a) or (b) (as appropriate) for each additional class
of relevant security.

3. DEALINGS (IF ANY) BY THE PERSON MAKING THE DISCLOSURE

(a) Purchases and sales

Class of relevant

Purchase/sale

Number of

Price per unit

security

securities

ORD

Purchase

50

TRANSFER

ORD

Purchase

100

55.5200 USD

ORD

Purchase

100

55.6250 USD

ORD

Purchase

126

55.5796 USD

ORD

Purchase

200

55.5600 USD

ORD

Purchase

200

55.6325 USD

ORD

Purchase

200

55.6700 USD

ORD

Purchase

240

55.6216 USD

ORD

Purchase

248

55.6079 USD

ORD

Purchase

296

55.6500 USD

ORD

Purchase

300

55.5800 USD

ORD

Purchase

300

55.6060 USD

ORD

Purchase

333

55.8500 USD

ORD

Purchase

400

55.6062 USD

ORD

Purchase

464

55.5100 USD

ORD

Purchase

500

55.6090 USD

ORD

Purchase

531

55.6295 USD

ORD

Purchase

534

55.5382 USD

ORD

Purchase

562

55.6200 USD

ORD

Purchase

583

55.4940 USD

ORD

Purchase

652

55.6100 USD

ORD

Purchase

682

55.5823 USD

ORD

Purchase

700

55.6000 USD

ORD

Purchase

780

55.5603 USD

ORD

Purchase

800

55.5700 USD

ORD

Purchase

800

55.5875 USD

ORD

Purchase

800

55.5888 USD

ORD

Purchase

821

55.6312 USD

ORD

Purchase

899

55.5900 USD

ORD

Purchase

900

55.5572 USD

ORD

Purchase

900

55.5855 USD

ORD

Purchase

906

55.6400 USD

ORD

Purchase

1,000

55.5749 USD

ORD

Purchase

1,100

55.6390 USD

ORD

Purchase

1,180

55.5581 USD

ORD

Purchase

1,200

55.5650 USD

ORD

Purchase

1,581

55.6374 USD

ORD

Purchase

2,401

55.6110 USD

ORD

Purchase

2,600

55.6025 USD

ORD

Purchase

2,846

55.5785 USD

ORD

Purchase

4,500

55.5845 USD

ORD

Purchase

5,797

55.5934 USD

ORD

Purchase

6,187

55.5825 USD

ORD

Purchase

6,367

55.5918 USD

ORD

Purchase

7,841

55.6048 USD

ORD

Purchase

9,615

55.5427 USD

ORD

Purchase

9,957

55.5901 USD

ORD

Purchase

11,558

55.6026 USD

ORD

Purchase

11,700

55.6076 USD

ORD

Purchase

15,438

55.6061 USD

ORD

Purchase

22,700

55.5937 USD

ORD

Purchase

32,861

55.5031 USD

ORD

Purchase

40,595

55.5947 USD

ORD

Purchase

75,078

55.5783 USD

ORD

Purchase

88,100

55.5969 USD

ORD

Purchase

123,300

55.5786 USD

ORD

Purchase

173,917

55.5664 USD

ORD

Purchase

300,500

55.6149 USD

ORD

Purchase

362,337

55.6057 USD

ORD

Purchase

2,499,216

55.7000 USD

ORD

Sale

5

55.6170 USD

ORD

Sale

6

55.6008 USD

ORD

Sale

6

55.6041 USD

ORD

Sale

6

55.6133 USD

ORD

Sale

33

55.5400 USD

ORD

Sale

62

55.6600 USD

ORD

Sale

100

55.5200 USD

ORD

Sale

100

55.5500 USD

ORD

Sale

100

55.6050 USD

ORD

Sale

100

55.6350 USD

ORD

Sale

100

55.6550 USD

ORD

Sale

127

55.4670 USD

ORD

Sale

164

55.6500 USD

ORD

Sale

180

55.5480 USD

ORD

Sale

199

55.6048 USD

ORD

Sale

200

55.5150 USD

ORD

Sale

200

55.5750 USD

ORD

Sale

200

55.5800 USD

ORD

Sale

200

55.5850 USD

ORD

Sale

200

55.6475 USD

ORD

Sale

201

55.5827 USD

ORD

Sale

202

55.6248 USD

ORD

Sale

282

55.6122 USD

ORD

Sale

300

55.5866 USD

ORD

Sale

300

55.6033 USD

ORD

Sale

300

55.6300 USD

ORD

Sale

333

55.8500 USD

ORD

Sale

346

55.4539 USD

ORD

Sale

346

55.6018 USD

ORD

Sale

400

55.4500 USD

ORD

Sale

400

55.5900 USD

ORD

Sale

400

55.6100 USD

ORD

Sale

500

55.5820 USD

ORD

Sale

500

55.6320 USD

ORD

Sale

510

55.6088 USD

ORD

Sale

600

55.5300 USD

ORD

Sale

688

55.5738 USD

ORD

Sale

700

55.6057 USD

ORD

Sale

705

55.5469 USD

ORD

Sale

787

55.6003 USD

ORD

Sale

1,035

55.5914 USD

ORD

Sale

1,073

55.5977 USD

ORD

Sale

1,100

55.5809 USD

ORD

Sale

1,132

55.5967 USD

ORD

Sale

1,200

55.6020 USD

ORD

Sale

1,213

55.5990 USD

ORD

Sale

1,224

55.5907 USD

ORD

Sale

1,300

55.5576 USD

ORD

Sale

1,300

55.5884 USD

ORD

Sale

1,400

55.5896 USD

ORD

Sale

1,500

55.5700 USD

ORD

Sale

1,609

55.5816 USD

ORD

Sale

1,623

55.5768 USD

ORD

Sale

1,707

55.5974 USD

ORD

Sale

1,800

55.6125 USD

ORD

Sale

1,820

55.5986 USD

ORD

Sale

2,100

55.6082 USD

ORD

Sale

2,300

55.6000 USD

ORD

Sale

2,365

55.6087 USD

ORD

Sale

2,600

55.6257 USD

ORD

Sale

2,700

55.5951 USD

ORD

Sale

2,702

55.5292 USD

ORD

Sale

2,800

55.5771 USD

ORD

Sale

2,800

55.6075 USD

ORD

Sale

2,903

55.5826 USD

ORD

Sale

3,000

55.6028 USD

ORD

Sale

3,098

55.5552 USD

ORD

Sale

3,706

55.6292 USD

ORD

Sale

3,935

55.5875 USD

ORD

Sale

3,954

55.5867 USD

ORD

Sale

4,392

55.7533 USD

ORD

Sale

4,400

55.5640 USD

ORD

Sale

5,395

55.5762 USD

ORD

Sale

5,566

55.5895 USD

ORD

Sale

6,100

55.5687 USD

ORD

Sale

6,400

55.5639 USD

ORD

Sale

7,388

55.6250 USD

ORD

Sale

7,915

55.5980 USD

ORD

Sale

9,877

55.5414 USD

ORD

Sale

10,000

55.6070 USD

ORD

Sale

13,541

55.5823 USD

ORD

Sale

15,225

55.5550 USD

ORD

Sale

16,752

55.5554 USD

ORD

Sale

17,800

55.5615 USD

ORD

Sale

19,474

55.5431 USD

ORD

Sale

21,047

55.5908 USD

ORD

Sale

21,749

55.5606 USD

ORD

Sale

21,900

55.5925 USD

ORD

Sale

23,094

55.5490 USD

ORD

Sale

23,635

55.5943 USD

ORD

Sale

23,707

55.5843 USD

ORD

Sale

25,230

55.5525 USD

ORD

Sale

25,571

55.5945 USD

ORD

Sale

30,373

55.6176 USD

ORD

Sale

31,199

55.5577 USD

ORD

Sale

32,661

55.5027 USD

ORD

Sale

35,661

55.5858 USD

ORD

Sale

48,700

55.6063 USD

ORD

Sale

49,395

55.5953 USD

ORD

Sale

52,596

55.6124 USD

ORD

Sale

53,074

55.6230 USD

ORD

Sale

55,067

55.5551 USD

ORD

Sale

71,093

55.5944 USD

ORD

Sale

86,987

55.5819 USD

ORD

Sale

118,949

55.5982 USD

ORD

Sale

132,368

55.8213 USD

ORD

Sale

300,500

55.6149 USD

ORD

Sale

2,512,501

55.7000 USD

(b) Derivatives transactions (other than options)

Class of

Product

Nature of dealing

Number of

Price per

relevant

description

reference

unit

security

securities

ORD

SWAP

Long

132,368

55.8213 USD

(c) Options transactions in respect of existing securities

(i) Writing, selling, purchasing or varying

Class

Product

Writing,

Number

Exercise

Type

Expiry

Option

of

description

purchasing,

of

price

date

money

relevant

selling,

securities

per unit

paid/

security

varying etc

to which

received

option

per unit

relates

ORD

Call Options

Purchasing

200

60 USD

American

17 Jan 2015

1.1350 USD

ORD

Call Options

Purchasing

100

70 USD

American

17 Jan 2015

0.1200 USD

ORD

Call Options

Selling

100

60 USD

American

17 Jan 2015

1.2400 USD

(ii) Exercising

Class of relevant security

Product description

e.g. call option

Number of securities

Exercise price per unit

(d) Other dealings (including subscribing for new securities)

Class of relevant security

Nature of dealing

e.g. subscription, conversion

Details

Price per unit (if applicable)

The currency of all prices and other monetary amounts should be stated.

Where there have been dealings in more than one class of relevant
securities of the offeror or offeree named in 1(c), copy table 3(a),
(b), (c) or (d) (as appropriate) for each additional class of relevant
security dealt in.

4. OTHER INFORMATION

(a) Indemnity and other dealing arrangements

Details of any indemnity or option arrangement, or any agreement or
understanding, formal or informal, relating to relevant securities
which may be an inducement to deal or refrain from dealing entered
into by the person making the disclosure and any party to the offer
or any person acting in concert with a party to the offer:

If there are no such agreements, arrangements or understandings,
state “none”

NONE

(b) Agreements, arrangements or understandings relating to options or
derivatives

Details of any agreement, arrangement or understanding, formal or
informal, between the person making the disclosure and any other
person relating to:

(i) the voting rights of any relevant securities under any option;
or

(ii) the voting rights or future acquisition or disposal of any
relevant securities to which any derivative is referenced:

If there are no such agreements, arrangements or understandings,
state “none”

NONE

(c) Attachments

Is a Supplemental Form 8 (Open Positions) attached?

YES

Date of disclosure:

28 Aug 2014

Contact name:

Rajesh Muthanna

Telephone number:

020 3555 4634

Public disclosures under Rule 8 of the Code must be made to a Regulatory
Information Service and must also be emailed to the Takeover Panel at monitoring@disclosure.org.uk.
The Panel’s Market Surveillance Unit is available for consultation in
relation to the Code’s dealing disclosure requirements on +44 (0)20 7638
0129.