ntervene early to potentially avoid rejection-associated kidney damage. The protein levels began to drop after treatment for rejection, suggesting that the urine test could be used to monitor treatment progress.

"Development of noninvasive tests to detect immune activation before kidney damage occurs would help guide the care of kidney transplant recipients," said NIAID Transplantation Branch Chief Nancy Bridges, M.D., a co-author of the paper. "Clinical application of the findings from this study could help avoid unnecessary biopsies and excess immunosuppression."

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