This gene encodes the rate-limiting enzyme of the polyamine biosynthesis pathway which catalyzes ornithine to putrescine. The activity level for the enzyme varies in response to growth-promoting stimuli and exhibits a high turnover rate in comparison to other mammalian proteins. Originally localized to both chromosomes 2 and 7 the gene encoding this enzyme has been determined to be located on 2p25 with a pseudogene located on 7q31-qter. [provided by RefSeq Jul 2008]

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