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By way of a bump and a comment, many (many) years ago when I was working in A and E a very irate (and wheezy) man came in asking for a new ventolin inhaler because his wasn't working. He was absolutely convinced that Allen and Hanbury had done something wrong in the manufacture, or skimped on the active ingredient, as he was getting no relief at all from more or less a whole canister. He was not at all interested in the alternative explanation that his asthma might be getting worse, though we persuaded him to come in in the end as he was really unwell. He went off to the ward muttering about sueing drug companies......

Having said which, I do understand that when the ventolin stops working, it somehow _feels_ as if the wretched stuff has been diluted!