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Wenyong Tan

DirectorSouthern Medial UniversityChina

Prof. Wenyong Tan, has been a clinical oncologist for 20 years, and he was the director of the Department of Oncology, Southern Medical University Shenzhen Hospital. His focus is on radiation and medical oncology for cancer patients. Prof. Tan is mainly devoted to the research and clinical practice of lung cancer, breast cancer as well as the head and neck cancer. The research and clinical treatment of anti-cancer associated to cardiac toxicities is one of the topics he is most interested in. He has published more than 30 academic papers in collaboration with co-authors and 7 international meeting abstracts .

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Latest work with IntechOpen by Wenyong Tan

Cardiotoxicity may be caused by radiotherapy and/or anticancer agents for many malignancies, adverse effects of some drugs in the context of medical intervention or heavy metal intake, especially during the anticancer therapy. This book intends to bring forward the recent development in toxicities from cancer treatment. It updates the possible mechanisms of cardiotoxicities of some anticancer agents and the suggested prevention and treatment strategies. This book contains many valuable contributions from the researchers in oncology and cardiology as well as the clinicians who are experts in this field.

Chapters authored

Approximately 25–30% of patients with cancer undergo thoracic radiation therapy (RT). RT might inadvertently induce heart injury and result in various forms of radiation-related heart disease (RRHD). The main endpoints of RRHD include cardiac death from RT, clinical heart disease (congestive heart disease, ischemic heart disease, and myocardial infarction), and subclinical heart disease (cardiac perfusion defects). Advanced RT techniques, such as breath control, intensity-modulated RT, and image-guided RT, as well as limited target volume definition might spare or avoid cardiac doses and/or volume, which may translate into decreased incidence of RRHD. The total delivered radiation dose to cardiac implantable electronic devices was strongly recommended not to exceed 2 Gy. The treatment strategies of RRHD were based on the various recommended consensus of related heart diseases in cardiology. However, the standardized definitions of the cardiac structures, dose-volume limits during radiation planning design, the optimal dose-volume parameters, and the dose-volume effects of various cardiac substructures warrant further investigation. The recognition, prediction, prevention, and management of RRHD require close collaboration between oncologists and cardiologists.