The trial originally was meant to have 84 patients enrolled, but due to the drastic difference in outcomes between the two arms, the trial was closed after only 21 patients were enrolled. The patients who received the combination performed much better, with fewer relapses, than the patients who received standard of care.

While the low enrollment limited the information that the researchers could gather from the trial, they did see that the patients on dabrafenib plus trametinib saw a higher rate of pathologic complete response, which seems to correlate with improved relapse-free survival, and perhaps even overall survival.

The trial originally was meant to have 84 patients enrolled, but due to the drastic difference in outcomes between the two arms, the trial was closed after only 21 patients were enrolled. The patients who received the combination performed much better, with fewer relapses, than the patients who received standard of care.

While the low enrollment limited the information that the researchers could gather from the trial, they did see that the patients on dabrafenib plus trametinib saw a higher rate of pathologic complete response, which seems to correlate with improved relapse-free survival, and perhaps even overall survival.