Background: Prostate cancer is the second most prevalent canceramong men and the eighth leading cause of death in Iran. In pathological conditions, angiogenesis increases the chance of metastasis and thus spreads cancer. The aim of the present study was to examine the effects of 10 weeks of resistance training on some angiogenesis factors among men affected by prostate cancer.Materials and Methods: Twenty men with prostate cancer aged between 55 and 62 were selected and randomly divided into control (n=10) and resistance training groups (n=10). The experimental group performed 10 weeks of resistance training, three sessions per week. Each exercise includes three sets of twelve repetitions with the intensity of 50-65 percent of 1RM. In order to measurement of NO, FGF and VEGF, blood samples were taken from the participants after 12 hours fasting state 24 hours before and 48 after the last training. For comparison of means between and within group's independent and dependent T test were used, respectively.Results: The results showed that ten weeks of resistance training significantly increase the levels of VEGF ( P=0.0001), FGF (P=0.0001) and NO (P=0.0003) in men suffering from prostate cancer.Conclusion: It appears 10 weeks of resistance training cause increase the level of angiogenesis factors, muscular strength and mass and decrease fatigue in men affected by prostate cancer.