The purpose of this article was to determine opinions on the use of abstinence only versus comprehensive sex education by registered voters in South Carolina. A cross-sectional, random-digit dial sample was utilized. Approximately 81% of respondents indicated support for sex education that emphasizes abstinence but also teaches about the benefits and importance of using contraceptives to prevent pregnancy and/or sexually transmitted diseases. Results suggest that registered voters in South Carolina support teaching a comprehensive approach to sex education and favor a variety of sex education topics, regardless of political ideology, religion, or parental status. (Contains 7 tables and 1 figure.)