Bernard: Oh, you’re going to zap me with penicillin and pesticides. Spare me that and I’ll spare you the bomb and aerosols. But don’t confuse progress with perfectibility. A great poet is always timely. A great philosopher is an urgent need. There’s no rush for Isaac Newton. We were quite happy with Aristotle’s cosmos. Personally, I preferred it. Fifty-five crystal spheres geared to God’s crankshaft is my idea of a satisfying universe. I can’t think of anything more trivial than the speed of light. Quarks, quasars—big bangs, black holes—who [cares]? How did you people con us out of all that status? All that money? And why are you so pleased with yourselves?Chloe: Are you against penicillin, Bernard?Bernard: Don’t feed the animals.

La théorie est l’hypothèse vérifiée, après qu’elle a été soumise au contrôle du raisonnement et de la critique expérimentale. La meilleure théorie est celle qui a été vérifiée par le plus grand nombre de faits. Mais une théorie, pour rester bonne, doit toujours se modifier avec les progrès de la science et demeurer constamment soumise à la vérification et à la critique des faits nouveaux qui apparaissent.A theory is a verified hypothesis, after it has been submitted to the control of reason and experimental criticism. The soundest theory is one that has been verified by the greatest number of facts. But to remain valid, a theory must be continually altered to keep pace with the progress of science and must be constantly resubmitted to verification and criticism as new facts appear.

Original work in French, Introduction à l'Étude de la Médecine Expérimentale (1865), 385. English translation by Henry Copley Green in An Introduction to the Study of Experimental Medicine (1927, 1957), 220.

A discovery in science, or a new theory, even when it appears most unitary and most all-embracing, deals with some immediate element of novelty or paradox within the framework of far vaster, unanalysed, unarticulated reserves of knowledge, experience, faith, and presupposition. Our progress is narrow; it takes a vast world unchallenged and for granted. This is one reason why, however great the novelty or scope of new discovery, we neither can, nor need, rebuild the house of the mind very rapidly. This is one reason why science, for all its revolutions, is conservative. This is why we will have to accept the fact that no one of us really will ever know very much. This is why we shall have to find comfort in the fact that, taken together, we know more and more.

A great man, [who] was convinced that the truths of political and moral science are capable of the same certainty as those that form the system of physical science, even in those branches like astronomy that seem to approximate mathematical certainty.He cherished this belief, for it led to the consoling hope that humanity would inevitably make progress toward a state of happiness and improved character even as it has already done in its knowledge of the truth.

A noteworthy and often-remarked similarity exists between the facts and methods of geology and those of linguistic study. The science of language is, as it were, the geology of the most modern period, the Age of the Man, having for its task to construct the history of development of the earth and its inhabitants from the time when the proper geological record remains silent … The remains of ancient speech are like strata deposited in bygone ages, telling of the forms of life then existing, and of the circumstances which determined or affected them; while words are as rolled pebbles, relics of yet more ancient formations, or as fossils, whose grade indicates the progress of organic life, and whose resemblances and relations show the correspondence or sequence of the different strata; while, everywhere, extensive denudation has marred the completeness of the record, and rendered impossible a detailed exhibition of the whole course of development.

A political law or a scientific truth may be perilous to the morals or the faith of individuals; but it cannot on this ground be resisted by the Church. … A discovery may be made in science which will shake the faith of thousands; yet religion cannot regret it or object to it. The difference in this respect between a true and a false religion is, that one judges all things by the standard of their truth, the other by the touchstone of its own interests. A false religion fears the progress of all truth; a true religion seeks and recognises truth wherever it can be found.

From 'Cardinal Wiseman and the Home and Foreign Review' (1862), collected in John Emerich Edward Dalberg Acton Baron Acton, John Neville Figgis (ed.) and Reginald Vere Laurence (ed.), The History of Freedom and Other Essays (1907), 449-450. The Darwinian controversy was at its height when this was written.

Alcoholism, the opium habit and tobaccoism are a trio of poison habits which have been weighty handicaps to human progress during the last three centuries. In the United States, the subtle spell of opium has been broken by restrictive legislation; the grip of the rum demon has been loosened by the Prohibition Amendment to the Constitution, but the tobacco habit still maintains its strangle-hold and more than one hundred million victims of tobaccoism daily burn incense to the smoke god.

An inventor is an opportunist, one who takes occasion by the hand; who, having seen where some want exists, successfully applies the right means to attain the desired end. The means may be largely, or even wholly, something already known, or there may be a certain originality or discovery in the means employed. But in every case the inventor uses the work of others. If I may use a metaphor, I should liken him to the man who essays the conquest of some virgin alp. At the outset he uses the beaten track, and, as he progresses in the ascent, he uses the steps made by those who have preceded him, whenever they lead in the right direction; and it is only after the last footprints have died out that he takes ice-axe in hand and cuts the remaining steps, few or many, that lift him to the crowning height which is his goal.

Any one who has studied the history of science knows that almost every great step therein has been made by the “anticipation of Nature,” that is, by the invention of hypotheses, which, though verifiable, often had very little foundation to start with; and, not unfrequently, in spite of a long career of usefulness, turned out to be wholly erroneous in the long run.

Arts and sciences in one and the same century have arrived at great perfection; and no wonder, since every age has a kind of universal genius, which inclines those that live in it to some particular studies; the work then, being pushed on by many hands, must go forward.

Ask a follower of Bacon what [science] the new philosophy, as it was called in the time of Charles the Second, has effected for mankind, and his answer is ready; “It has lengthened life; it has mitigated pain; it has extinguished diseases; it has increased the fertility of the soil; it has given new securities to the mariner; it has furnished new arms to the warrior; it has spanned great rivers and estuaries with bridges of form unknown to our fathers; it has guided the thunderbolt innocuously from heaven to earth; it has lighted up the night with the splendour of the day; it has extended the range of the human vision; it has multiplied the power of the human muscles; it has accelerated motion; it has annihilated distance; it has facilitated intercourse, correspondence, all friendly offices, all dispatch of business; it has enabled man to descend to the depths of the sea, to soar into the air, to penetrate securely into the noxious recesses of the earth, to traverse the land in cars which whirl along without horses, to cross the ocean in ships which run ten knots an hour against the wind. These are but a part of its fruits, and of its first-fruits; for it is a philosophy which never rests, which has never attained, which is never perfect. Its law is progress. A point which yesterday was invisible is its goal to-day, and will be its starting-point to-morrow.”

Astronomy, as the science of cyclical motions, has nothing in common with Geology. But look at Astronomy where she has an analogy with Geology; consider our knowledge of the heavens as a palaetiological science;—as the study of a past condition, from which the present is derived by causes acting in time. Is there no evidence of a beginning, or of a progress?

At present good work in science pays less well very often than mediocrity in other subjects. This, as was pointed out by Sir Lyon Playfair in his Presidential Address to the British Association in 1885 helps to arrest progress in science teaching.

In Sir Norman Lockyer (ed.), 'Physical Science and the Woolwich Examinations', Nature (23 Feb 1888), 37, 386. Webmaster has assumed this unsigned lead article (editorial?) should be attributed to the Editor.

Be you in what line of life you may, it will be amongst your misfortunes if you have not time properly to attend to [money management]; for. ... want of attention to pecuniary matters … has impeded the progress of science and of genius itself.

Because a fact seems strange to you, you conclude that it is not one. ... All science, however, commences by being strange. Science is successive. It goes from one wonder to another. It mounts by a ladder. The science of to-day would seem extravagant to the science of a former time. Ptolemy would believe Newton mad.

Biology is a science of three dimensions. The first is the study of each species across all levels of biological organization, molecule to cell to organism to population to ecosystem. The second dimension is the diversity of all species in the biosphere. The third dimension is the history of each species in turn, comprising both its genetic evolution and the environmental change that drove the evolution. Biology, by growing in all three dimensions, is progressing toward unification and will continue to do so.

By the death of Mr. O. Chanute the world has lost one whose labors had to an unusual degree influenced the course of human progress. If he had not lived the entire history of progress in flying would have been other than it has been.

Casting off the dark fog of verbal philosophy and vulgar medicine, which inculcate names alone ... I tried a series of experiments to explain more clearly many phenomena, particularly those of physiology. In order that I might subject as far as possible the reasonings of the Galenists and Peripatetics to sensory criteria, I began, after trying experiments, to write dialogues in which a Galenist adduced the better-known and stronger reasons and arguments; these a mechanist surgeon refuted by citing to the contrary the experiments I had tried, and a third, neutral interlocutor weighed the reasons advanced by both and provided an opportunity for further progress.

Committees are dangerous things that need most careful watching. I believe that a research committee can do one useful thing and one only. It can find the workers best fitted to attack a particular problem, bring them together, give them the facilities they need, and leave them to get on with the work. It can review progress from time to time, and make adjustments; but if it tries to do more, it will do harm.

Decades spent in contact with science and its vehicles have directed my mind and senses to areas beyond their reach. I now see scientific accomplishments as a path, not an end; a path leading to and disappearing in mystery. Science, in fact, forms many paths branching from the trunk of human progress; and on every periphery they end in the miraculous. Following these paths far enough, one must eventually conclude that science itself is a miracle—like the awareness of man arising from and then disappearing in the apparent nothingness of space. Rather than nullifying religion and proving that “God is dead,” science enhances spiritual values by revealing the magnitudes and minitudes—from cosmos to atom—through which man extends and of which he is composed.

Disease is largely a removable evil. It continues to afflict humanity, not only because of incomplete knowledge of its causes and lack of individual and public hygiene, but also because it is extensively fostered by harsh economic and industrial conditions and by wretched housing in congested communities. ... The reduction of the death rate is the principal statistical expression and index of human social progress. It means the saving and lengthening of lives of thousands of citizens, the extension of the vigorous working period well into old age, and the prevention of inefficiency, misery, and suffering. These advances can be made by organized social effort. Public health is purchasable. (1911)

Do not expect to be hailed as a hero when you make your great discovery. More likely you will be a ratbag—maybe failed by your examiners. Your statistics, or your observations, or your literature study, or your something else will be patently deficient. Do not doubt that in our enlightened age the really important advances are and will be rejected more often than acclaimed. Nor should we doubt that in our own professional lifetime we too will repudiate with like pontifical finality the most significant insight ever to reach our desk.

Engineering is not merely knowing and being knowledgeable, like a walking encyclopedia; engineering is not merely analysis; engineering is not merely the possession of the capacity to get elegant solutions to non-existent engineering problems; engineering is practicing the art of the organizing forces of technological change ... Engineers operate at the interface between science and society.

Essentially only one thing in life interests us: our psychical constitution, the mechanism of which was and is wrapped in darkness. All human resources, art, religion, literature, philosophy and historical sciences, all of them join in bringing lights in this darkness. But man has still another powerful resource: natural science with its strictly objective methods. This science, as we all know, is making huge progress every day. The facts and considerations which I have placed before you at the end of my lecture are one out of numerous attempts to employ a consistent, purely scientific method of thinking in the study of the mechanism of the highest manifestations of life in the dog, the representative of the animal kingdom that is man's best friend.

Ever so often in the history of human endeavour, there comes a breakthrough that takes humankind across a frontier into a new era. ... today's announcement is such a breakthrough, a breakthrough that opens the way for massive advancement in the treatment of cancer and hereditary diseases. And that is only the beginning.

From White House Announcement of the Completion of the First Survey of the Entire Human Genome Project, broadcast on the day of the publication of the first draft of the human genome. Quoted in transcript on the National Archives, Clinton White House web site, 'Text of Remarks on the Completion of the First Survey of the Entire Human Genome Project' (26 Jun 2000).

Experience hobbles progress and leads to abandonment of difficult problems; it encourages the initiated to walk on the shady side of the street in the direction of experiences that have been pleasant. Youth without experience attacks the unsolved problems which maturer age with experience avoids, and from the labors of youth comes progress. Youth has dreams and visions, and will not be denied.

Faced with the challenge of an endless universe, Man will be forced to mature further, just as the Neanderthal—faced with an entire planet—had no choice but to grow away from the tradition of savagery.

Genuine religion has its root deep down in the heart of humanity and in the reality of things. It is not surprising that by our methods we fail to grasp it: the actions of the Deity make no appeal to any special sense, only a universal appeal; and our methods are, as we know, incompetent to detect complete uniformity. There is a principle of Relativity here, and unless we encounter flaw or jar or change, nothing in us responds; we are deaf and blind therefore to the Immanent Grandeur, unless we have insight enough to recognise in the woven fabric of existence, flowing steadily from the loom in an infinite progress towards perfection, the ever-growing garment of a transcendent God.

Great steps in human progress are made by things that don't work the way philosophy thought they should. If things always worked the way they should, you could write the history of the world from now on. But they don't, and it is those deviations from the normal that make human progress.

Houses were knocked down... enormous heaps of earth and clay thrown up; buildings that were undermined and shaking, propped up by great beams of wood... The yet unfinished and unopened Railway was in progress.

I am mindful that scientific achievement is rooted in the past, is cultivated to full stature by many contemporaries and flourishes only in favorable environment. No individual is alone responsible for a single stepping stone along the path of progress, and where the path is smooth progress is most rapid. In my own work this has been particularly true.

I believe in intuition and inspiration. Imagination is more important than knowledge. For knowledge is limited, whereas imagination embraces the entire world, stimulating progress, giving birth to evolution. It is, strictly speaking, a real factor in scientific research.

I have no patience with attempts to identify science with measurement, which is but one of its tools, or with any definition of the scientist which would exclude a Darwin, a Pasteur or a Kekulé. The scientist is a practical man and his are practical aims. He does not seek the ultimate but the proximate. He does not speak of the last analysis but rather of the next approximation. His are not those beautiful structures so delicately designed that a single flaw may cause the collapse of the whole. The scientist builds slowly and with a gross but solid kind of masonry. If dissatisfied with any of his work, even if it be near the very foundations, he can replace that part without damage to the remainder. On the whole, he is satisfied with his work, for while science may never be wholly right it certainly is never wholly wrong; and it seems to be improving from decade to decade.

I have tried to read philosophers of all ages and have found many illuminating ideas but no steady progress toward deeper knowledge and understanding. Science, however, gives me the feeling of steady progress: I am convinced that theoretical physics is actual philosophy. It has revolutionized fundamental concepts, e.g., about space and time (relativity), about causality (quantum theory), and about substance and matter (atomistics), and it has taught us new methods of thinking (complementarity) which are applicable far beyond physics.

I know that certain minds would regard as audacious the idea of relating the laws which preside over the play of our organs to those laws which govern inanimate bodies; but, although novel, this truth is none the less incontestable. To hold that the phenomena of life are entirely distinct from the general phenomena of nature is to commit a grave error, it is to oppose the continued progress of science.

I never found it easy. People say I was lucky twice but I resent that. We stuck with [cimetidine] for four years with no progress until we eventually succeeded. It was not luck, it was bloody hard work.[Rejecting that drug discovery was easier in the past.]

I remember my first look at the great treatise of Maxwell’s when I was a young man… I saw that it was great, greater and greatest, with prodigious possibilities in its power… I was determined to master the book and set to work. I was very ignorant. I had no knowledge of mathematical analysis (having learned only school algebra and trigonometry which I had largely forgotten) and thus my work was laid out for me. It took me several years before I could understand as much as I possibly could. Then I set Maxwell aside and followed my own course. And I progressed much more quickly… It will be understood that I preach the gospel according to my interpretation of Maxwell.

From translations of a letter (24 Feb 1918), cited in Paul J. Nahin, Oliver Heaviside: The Life, Work, and Times of an Electrical Genius of the Victorian Age (2002), 24. Nahin footnotes that the words are not verbatim, but are the result of two translations. Heaviside's original letter in English was quoted, translated in to French by J. Bethenode, for the obituary he wrote, "Oliver Heaviside", in Annales des Posies Telegraphs (1925), 14, 521-538. The quote was retranslated back to English in Nadin's book. Bethenode footnoted that he made the original translation "as literally as possible in order not to change the meaning." Nadin assures that the retranslation was done likewise. Heaviside studyied Maxwell's two-volume Treatise on Electricity and Magnetism.

I think chemistry is being frittered away by the hairsplitting of the organic chemists; we have new compounds discovered, which scarcely differ from the known ones and when discovered are valueless—very illustrations perhaps of their refinements in analysis, but very little aiding the progress of true science.

If human thought is a growth, like all other growths, its logic is without foundation of its own, and is only the adjusting constructiveness of all other growing things. A tree cannot find out, as it were, how to blossom, until comes blossom-time. A social growth cannot find out the use of steam engines, until comes steam-engine-time.

If science is to progress, what we need is the ability to experiment, honesty in reporting results—the results must be reported without somebody saying what they would like the results to have been—and finally—an important thing—the intelligence to interpret the results.

If the Commission is to enquire into the conditions “to be observed,” it is to be presumed that they will give the result of their enquiries; or, in other words, that they will lay down, or at least suggest, “rules” and “conditions to be (hereafter) observed” in the construction of bridges, or, in other words, embarrass and shackle the progress of improvement to-morrow by recording and registering as law the prejudices or errors of to-day.[Objecting to any interference by the State with the freedom of civil engineers in the conduct of their professional work.]

Letter (13 Mar 1848) to the Royal Commission on the Application of Iron in Railway Structures. Collected in The Life of Isambard Kingdom Brunel, Civil Engineer (1870), 487. The above verbatim quote may be the original source of the following statement as seen in books and on the web without citation: “I am opposed to the laying down of rules or conditions to be observed in the construction of bridges lest the progress of improvement tomorrow might be embarrassed or shackled by recording or registering as law the prejudices or errors of today.” Webmaster has not yet found a primary source for his latter form, and suspects it may be a synopsis, rather than a verbatim quote. If you know of such a primary source, please inform Webmaster.

If the task of scientific methodology is to piece together an account of what scientists actually do, then the testimony of biologists should be heard with specially close attention. Biologists work very close to the frontier between bewilderment and understanding.Biology is complex, messy and richly various, like real life; it travels faster nowadays than physics or chemistry (which is just as well, since it has so much farther to go), and it travels nearer to the ground. It should therefore give us a specially direct and immediate insight into science in the making.

In 1847 I gave an address at Newton, Mass., before a Teachers’ Institute conducted by Horace Mann. My subject was grasshoppers. I passed around a large jar of these insects, and made every teacher take one and hold it while I was speaking. If any one dropped the insect, I stopped till he picked it up. This was at that time a great innovation, and excited much laughter and derision. There can be no true progress in the teaching of natural science until such methods become general.

In 1945 J.A. Ratcliffe … suggested that I [join his group at Cavendish Laboratory, Cambridge] to start an investigation of the radio emission from the Sun, which had recently been discovered accidentally with radar equipment. … [B]oth Ratcliffe and Sir Lawrence Bragg, then Cavendish Professor, gave enormous support and encouragement to me. Bragg’s own work on X-ray crystallography involved techniques very similar to those we were developing for “aperture synthesis,” and he always showed a delighted interest in the way our work progressed.

In formal logic a contradiction is the signal of a defeat, but in the evolution of real knowledge it marks the first step in progress toward a victory. This is one great reason for the utmost toleration of variety of opinion. Once and forever, this duty of toleration has been summed up in the words, “Let both grow together until the harvest.”

In honoring the Wright Brothers, it is customary and proper to recognize their contribution to scientific progress. But I believe it is equally important to emphasize the qualities in their pioneering life and the character in man that such a life produced. The Wright Brothers balanced sucess with modesty, science with simplicity. At Kitty Hawk their intellects and senses worked in mutual support. They represented man in balance, and from that balance came wings to lift a world.

In less than eight years “The Origin of Species” has produced conviction in the minds of a majority of the most eminent living men of science. New facts, new problems, new difficulties as they arise are accepted, solved, or removed by this theory; and its principles are illustrated by the progress and conclusions of every well established branch of human knowledge.

From a review of four books on the subject 'Mimicry, and Other Protective Resemblances Among Animals', in The Westminster Review (Jul 1867), 88, 1. Wallace is identified as the author in the article as reprinted in William Beebe, The Book of Naturalists: An Anthology of the Best Natural History (1988), 108.

In no subject is there a rule, compliance with which will lead to new knowledge or better understanding. Skilful observations, ingenious ideas, cunning tricks, daring suggestions, laborious calculations, all these may be required to advance a subject. Occasionally the conventional approach in a subject has to be studiously followed; on other occasions it has to be ruthlessly disregarded. Which of these methods, or in what order they should be employed is generally unpredictable. Analogies drawn from the history of science are frequently claimed to be a guide; but, as with forecasting the next game of roulette, the existence of the best analogy to the present is no guide whatever to the future. The most valuable lesson to be learnt from the history of scientific progress is how misleading and strangling such analogies have been, and how success has come to those who ignored them.

In order to imbue civilization with sound principles and enliven it with the spirit of the gospel, it is not enough to be illumined with the gift of faith and enkindled with the desire of forwarding a good cause. For this end it is necessary to take an active part in the various organizations and influence them from within. And since our present age is one of outstanding scientific and technical progress and excellence, one will not be able to enter these organizations and work effectively from within unless he is scientifically competent, technically capable and skilled in the practice of his own profession.

In science, each of us knows that what he has accomplished will be antiquated in ten, twenty, fifty years. That is the fate to which science is subjected; it is the very meaning of scientific work, to which it is devoted in a quite specific sense, as compared with other spheres of culture for which in general the same holds. Every scientific “fulfilment” raises new “questions”; it asks to be “surpassed” and outdated. Whoever wishes to serve science has to resign himself to this fact. Scientific works certainly can last as “gratifications” because of their artistic quality, or they may remain important as a means of training. Yet they will be surpassed scientifically—let that be repeated—for it is our common fate and, more our common goal. We cannot work without hoping that others will advance further than we have. In principle, this progress goes on ad infinitum.

In the main, Bacon prophesied the direction of subsequent progress. But he “anticipated” the advance. He did not see that the new science was for a long time to be worked in the interest of old ends of human exploitation. He thought that it would rapidly give man new ends. Instead, it put at the disposal of a class the means to secure their old ends of aggrandizement at the expense of another class. The industrial revolution followed, as he foresaw, upon a revolution in scientific method. But it is taking the revolution many centuries to produce a new mind.

In the modern interpretation of Mendelism, facts are being transformed into factors at a rapid rate. If one factor will not explain the facts, then two are involved; if two prove insufficient, three will sometimes work out. The superior jugglery sometimes necessary to account for the results may blind us, if taken too naively, to the common-place that the results are often so excellently 'explained' because the explanation was invented to explain them. We work backwards from the facts to the factors, and then, presto! explain the facts by the very factors that we invented to account for them. I am not unappreciative of the distinct advantages that this method has in handling the facts. I realize how valuable it has been to us to be able to marshal our results under a few simple assumptions, yet I cannot but fear that we are rapidly developing a sort of Mendelian ritual by which to explain the extraordinary facts of alternative inheritance. So long as we do not lose sight of the purely arbitrary and formal nature of our formulae, little harm will be done; and it is only fair to state that those who are doing the actual work of progress along Mendelian lines are aware of the hypothetical nature of the factor-assumption.

In the years since man unlocked the power stored up within the atom, the world has made progress, halting, but effective, toward bringing that power under human control. The challenge may be our salvation. As we begin to master the destructive potentialities of modern science, we move toward a new era in which science can fulfill its creative promise and help bring into existence the happiest society the world has ever known.

Industry is far more efficient than the university in making use of scientific developments for the public good.Reported in 1981, as a co-founder of Genentech, Inc., a company to offer gene-splicing products.

Inventive genius requires pleasurable mental activity as a condition for its vigorous exercise. “Necessity is the mother of invention” is a silly proverb. “Necessity is the mother of futile dodges” is much closer to the truth. The basis of growth of modern invention is science, and science is almost wholly the outgrowth of pleasurable intellectual curiosity.

Is what you are doing fun? Of course, physics is also fun—indeed it is an enjoyable way of life. One reason physics is fun is that each element of progress transforms an area of ignorance into knowledge, but it also creates, as a by-product, an amount of new and additional ignorance in excess of that which was reduced to understanding. Thus, the volume of delicious ignorance we produce is ever-expanding, like our exponentially exploding universe.

It amounts to a truism to say that progress in the practical arts of medicine in any of its branches, whether preventive or curative, only comes from the growth of accurate knowledge as it accumulates in the laboratories and studies of the various sciences.

It has been my misfortune never to have had any neighbours whose studies have led them towards the pursuit of natural knowledge; so that, for want of a companion to quicken my industry and sharpen my attention, I have made but slender progress in a kind of information to which I have been attached from my childhood.

It has hitherto been a serious impediment to the progress of knowledge, that is in investigating the origin or causes of natural productions, recourse has generally been had to the examination, both by experiment and reasoning, of what might be rather than what is. The laws or processes of nature we have every reason to believe invariable. Their results from time to time vary, according to the combinations of influential circumstances; but the process remains the same. Like the poet or the painter, the chemist may, and no doubt often' does, create combinations which nature never produced; and the possibility of such and such processes giving rise to such and such results, is no proof whatever that they were ever in natural operation.

It is arguable whether the human race have been gainers by the march of science beyond the steam engine. Electricity opens a field of infinite conveniences to ever greater numbers, but they may well have to pay dearly for them. But anyhow in my thought I stop short of the internal combustion engine which has made the world so much smaller. Still more must we fear the consequences of entrusting a human race so little different from their predecessors of the so-called barbarous ages such awful agencies as the atomic bomb. Give me the horse.

It is for such inquiries the modern naturalist collects his materials; it is for this that he still wants to add to the apparently boundless treasures of our national museums, and will never rest satisfied as long as the native country, the geographical distribution, and the amount of variation of any living thing remains imperfectly known. He looks upon every species of animal and plant now living as the individual letters which go to make up one of the volumes of our earth’s history; and, as a few lost letters may make a sentence unintelligible, so the extinction of the numerous forms of life which the progress of cultivation invariably entails will necessarily render obscure this invaluable record of the past. It is, therefore, an important object, which governments and scientific institutions should immediately take steps to secure, that in all tropical countries colonised by Europeans the most perfect collections possible in every branch of natural history should be made and deposited in national museums, where they may be available for study and interpretation. If this is not done, future ages will certainly look back upon us as a people so immersed in the pursuit of wealth as to be blind to higher considerations. They will charge us with having culpably allowed the destruction of some of those records of Creation which we had it in our power to preserve; and while professing to regard every living thing as the direct handiwork and best evidence of a Creator, yet, with a strange inconsistency, seeing many of them perish irrecoverably from the face of the earth, uncared for and unknown.

It is interesting to transport one’s self back to the times when Astronomy began; to observe how discoveries were connected together, how errors have got mixed up with truth, have delayed the knowledge of it, and retarded its progress; and, after having followed the various epochs and traversed every climate, finally to contemplate the edifice founded on the labours of successive centuries and of various nations.

Description of Bailly’s plan when writing his history of astronomy books, quoted by François Arago, trans. by William Henry Smyth, Baden Powell and Robert Grant, in 'Bailly', Biographies of Distinguished Scientific Men (1859), Vol. 1, 114. Arago first presented this biography of Bailly when he read it to the Academy of Sciences (26 Feb 1844).

It is not only by the questions we have answered that progress may be measured, but also by those we are still asking. The passionate controversies of one era are viewed as sterile preoccupations by another, for knowledge alters what we seek as well as what we find.

It is not, indeed, strange that the Greeks and Romans should not have carried ... any ... experimental science, so far as it has been carried in our time; for the experimental sciences are generally in a state of progression. They were better understood in the seventeenth century than in the sixteenth, and in the eighteenth century than in the seventeenth. But this constant improvement, this natural growth of knowledge, will not altogether account for the immense superiority of the modern writers. The difference is a difference not in degree, but of kind. It is not merely that new principles have been discovered, but that new faculties seem to be exerted. It is not that at one time the human intellect should have made but small progress, and at another time have advanced far; but that at one time it should have been stationary, and at another time constantly proceeding. In taste and imagination, in the graces of style, in the arts of persuasion, in the magnificence of public works, the ancients were at least our equals. They reasoned as justly as ourselves on subjects which required pure demonstration.

From White House Announcement of the Completion of the First Survey of the Entire Human Genome Project, broadcast on the day of the publication of the first draft of the human genome. Quoted in transcript on the National Archives, Clinton White House web site, 'Text of Remarks on the Completion of the First Survey of the Entire Human Genome Project' (26 Jun 2000).

It is the facts that matter, not the proofs. Physics can progress without the proofs, but we can't go on without the facts ... if the facts are right, then the proofs are a matter of playing around with the algebra correctly.

It is the modest, not the presumptuous, inquirer who makes a real and safe progress in the discovery of divine truths. One follows Nature and Nature’s God; that is, he follows God in his works and in his word.

Letter to Alexander Pope. As cited in John Bartlett, Familiar Quotations (1875, 10th ed., 1919), 304. The quote has a footnote to compare from Pope’s philosophical poem, Essay on Man (1733-34), epistle iv, lines 331-32: “Slave to no sect, who takes no private road, But looks through Nature up to Nature’s God.”

It is this ideal of progress through cumulative effort rather than through genius—progress by organised effort, progress which does not wait for some brilliant stroke, some lucky discovery, or the advent of some superman, has been the chief gift of science to social philosophy.

It is … genius which has given motion and progress to society; prevented the ossification of the human heart and brain; and though, in its processes, it may not ever have followed the rules laid down in primers, it has, at least, saved history from being the region of geology, and our present society from being a collection of fossil remains.

It troubles me that we are so easily pressured by purveyors of technology into permitting so-called “progress” to alter our lives without attempting to control it—as if technology were an irrepressible force of nature to which we must meekly submit.

It would be interesting to inquire how many times essential advances in science have first been made possible by the fact that the boundaries of special disciplines were not respected… Trespassing is one of the most successful techniques in science.

Just by studying mathematics we can hope to make a guess at the kind of mathematics that will come into the physics of the future ... If someone can hit on the right lines along which to make this development, it m may lead to a future advance in which people will first discover the equations and then, after examining them, gradually learn how to apply the ... My own belief is that this is a more likely line of progress than trying to guess at physical pictures.

Later scientific theories are better than earlier ones for solving puzzles in the often quite different environments to which they are applied. That is not a relativist's position, and it displays the sense in which I am a convinced believer in scientific progress.

Mankind lies groaning, half-crushed beneath the weight of its own progress. Men do not sufficiently realize that their future is in their own hands. Theirs is the task of determining first of all whether they want to go on living or not. Theirs the responsibility, then, for deciding if they want merely to live, or intend to make just the extra effort required for fulfilling, even on their refractory planet, the essential function of the universe, which is a machine for the making of gods.

The Two Sources of Morality and Religion, trans. by R. Ashley Audra and Cloudesley Brereton (1935), 275.

Many climate sceptics seem to review scientific data and studies not as scientists but as attorneys, magnifying doubts and treating incomplete explanations as falsehoods rather than signs of progress towards the truth.

Metals are the great agents by which we can examine the recesses of nature; and their uses are so multiplied, that they have become of the greatest importance in every occupation of life. They are the instruments of all our improvements, of civilization itself, and are even subservient to the progress of the human mind towards perfection. They differ so much from each other, that nature seems to have had in view all the necessities of man, in order that she might suit every possible purpose his ingenuity can invent or his wants require.

From 'Artist and Mechanic', The artist & Tradesman’s Guide: embracing some leading facts & principles of science, and a variety of matter adapted to the wants of the artist, mechanic, manufacturer, and mercantile community (1827), 16.

Modern civilization depends on science … James Smithson was well aware that knowledge should not be viewed as existing in isolated parts, but as a whole, each portion of which throws light on all the other, and that the tendency of all is to improve the human mind, and give it new sources of power and enjoyment … narrow minds think nothing of importance but their own favorite pursuit, but liberal views exclude no branch of science or literature, for they all contribute to sweeten, to adorn, and to embellish life … science is the pursuit above all which impresses us with the capacity of man for intellectual and moral progress and awakens the human intellect to aspiration for a higher condition of humanity.[Joseph Henry was the first Secretary of the Smithsonian Institution, named after its benefactor, James Smithson.]

The first phrase is inscribed on the National Museum of American History, Washington, D.C. In Library of Congress, Respectfully Quoted: A Dictionary of Quotations (1989), 313. From 'On the Smithsonian Institution', (Aug 1853), Proceedings of the Third Session of the American Association for the Advancement of Education (1854), 101.

Quoted in Roger Von Oech, A Whack on the Side of the Head (1982), 71. (Berger is credited in the Introduction in a listed of people providing ideas and suggestions.) In Cheryl Farr, Jim Rhode, Newsletters, Patients and You (1985), 142.

Most loss of life and property has been due to the collapse of antiquated and unsafe structures, mostly of brick and other masonry. ... There is progress of California toward building new construction according to earthquake-resistant design. We would have less reason to ask for earthquake prediction if this was universal.

Much is said about the progress of science in these centuries. I should say that the useful results of science had accumulated, but that there had been no accumulation of knowledge, strictly speaking, for posteriry; for knowledge is to be aquired only by corresponding experience. How can be know what we are told merely? Each man can interpret another's experience only by his own.

No history of civilization can be tolerably complete which does not give considerable space to the explanation of scientific progress. If we had any doubts about this, it would suffice to ask ourselves what constitutes the essential difference between our and earlier civilizations. Throughout the course of history, in every period, and in almost every country, we find a small number of saints, of great artists, of men of science. The saints of to-day are not necessarily more saintly than those of a thousand years ago; our artists are not necessarily greater than those of early Greece; they are more likely to be inferior; and of course, our men of science are not necessarily more intelligent than those of old; yet one thing is certain, their knowledge is at once more extensive and more accurate. The acquisition and systematization of positive knowledge is the only human activity which is truly cumulative and progressive. Our civilization is essentially different from earlier ones, because our knowledge of the world and of ourselves is deeper, more precise, and more certain, because we have gradually learned to disentangle the forces of nature, and because we have contrived, by strict obedience to their laws, to capture them and to divert them to the gratification of our own needs.

No! What we need are not prohibitory marriage laws, but a reformed society, an educated public opinion which will teach individual duty in these matters. And it is to the women of the future that I look for the needed reformation. Educate and train women so that they are rendered independent of marriage as a means of gaining a home and a living, and you will bring about natural selection in marriage, which will operate most beneficially upon humanity. When all women are placed in a position that they are independent of marriage, I am inclined to think that large numbers will elect to remain unmarried—in some cases, for life, in others, until they encounter the man of their ideal. I want to see women the selective agents in marriage; as things are, they have practically little choice. The only basis for marriage should be a disinterested love. I believe that the unfit will be gradually eliminated from the race, and human progress secured, by giving to the pure instincts of women the selective power in marriage. You can never have that so long as women are driven to marry for a livelihood.

Now, we propose in the first place to show, that this law of organic progress is the law of all progress. Whether it be in the development of the Earth, in the development in Life upon its surface, in the development of Society, of Government, of Manufactures, of Commerce, of Language, Literature, Science, Art, this same evolution of the simple into the complex, through a process of continuous differentiation, holds throughout. From the earliest traceable cosmical changes down to the latest results of civilization, we shall find that the transformation of the homogeneous into the heterogeneous is that in which Progress essentially consists.

One can truly say that the irresistible progress of natural science since the time of Galileo has made its first halt before the study of the higher parts of the brain, the organ of the most complicated relations of the animal to the external world. And it seems, and not without reason, that now is the really critical moment for natural science; for the brain, in its highest complexity—the human brain—which created and creates natural science, itself becomes the object of this science.

One of the ways of stopping science would be only to do experiments in the region where you know the law. … In other words we are trying to prove ourselves wrong as quickly as possible, because only in that way can we find progress.

Organization is simply the means by which the acts of ordinary men can be made to add up to extraordinary results. To this idea of progress that does not wait on some lucky break, some chance discovery, or some rare stroke of genius, but instead is achieved through systematic, cumulative effort, the engineer has contributed brilliantly.

Organs, faculties, powers, capacities, or whatever else we call them; grow by use and diminish from disuse, it is inferred that they will continue to do so. And if this inference is unquestionable, then is the one above deduced from it—that humanity must in the end become completely adapted to its conditions—unquestionable also. Progress, therefore, is not an accident, but a necessity.

People have noted with admiration how the progress of scientific enquiry is like the growth of a coral reef; each generation of little toilers building a sure foundation on which their successors may build yet further. The simile is apt in many ways, and in one way in particular that is worth considering. When we see how industrious and how prolific are the coral insects, our chief astonishment should be, not how vast are the structures they have built, but how few and scattered. Why is not every coast lined with coral? Why is the abyss if ocean not bridged with it. The answer is that coral only lives under certain limitations; it can only thrive at certain depths, in water of certain temperatures and salinities; outside these limits it languishes and dies. Science is like coral in this. Scientific investigators can only work in certain spots of the ocean of Being, where they are at home, and all outside is unknown to them...

Progress is achieved by exchanging our theories for new ones which go further than the old, until we find one based on a larger number of facts. … Theories are only hypotheses, verified by more or less numerous facts. Those verified by the most facts are the best, but even then they are never final, never to be absolutely believed.

Progress is made by trial and failure; the failures are generally a hundred times more numerous than the successes; yet they are usually left unchronicled. The reason is that the investigator feels that even though he has failed in achieving an expected result, some other more fortunate experimenter may succeed, and it is unwise to discourage his attempts.

Progress may have been all right once, but it went on too long;I think progress began to retrogress when Wilbur and Orville started tinkering around in Dayton and at Kitty Hawk, because I believe that two Wrights made a wrong.

Progress, far from consisting in change, depends on retentiveness. When change is absolute there remains no being to improve and no direction is set for possible improvement: and when experience is not retained, as among savages, infancy is perpetual. Those who cannot remember the past are condemned to repeat it.

Reason must approach nature with the view, indeed, of receiving information from it, not, however, in the character of a pupil, who listens to all that his master chooses to tell him, but in that of a judge, who compels the witnesses to reply to those questions which he himself thinks fit to propose. To this single idea must the revolution be ascribed, by which, after groping in the dark for so many centuries, natural science was at length conducted into the path of certain progress.

Red is the color in which the interior of the body is painted. If an operation be thought of as a painting in progress, and blood red the color on the brush, it must be suitably restrained and attract no undue attention; yet any insufficiency of it will increase the perishability of the canvas.

Remember that accumulated knowledge, like accumulated capital, increases at compound interest: but it differs from the accumulation of capital in this; that the increase of knowledge produces a more rapid rate of progress, whilst the accumulation of capital leads to a lower rate of interest. Capital thus checks its own accumulation: knowledge thus accelerates its own advance. Each generation, therefore, to deserve comparison with its predecessor, is bound to add much more largely to the common stock than that which it immediately succeeds.

Remember that [scientific thought] is the guide of action; that the truth which it arrives at is not that which we can ideally contemplate without error, but that which we may act upon without fear; and you cannot fail to see that scientific thought is not an accompaniment or condition of human progress, but human progress itself.

'Aims and Instruments of Scientific Thought,' a lecture delivered to the British Association on 19 Aug 1872. In Leslie Stephen and Frederick Pollock (eds.), Lectures and Essays, by the Late William Kingdon Clifford (1886), 109.

Science can never be a closed book. It is like a tree, ever growing, ever reaching new heights. Occasionally the lower branches, no longer giving nourishment to the tree, slough off. We should not be ashamed to change our methods; rather we should be ashamed never to do so.

Science does not mean an idle resting upon a body of certain knowledge; it means unresting endeavor and continually progressing development toward an end which the poetic intuition may apprehend, but which the intellect can never fully grasp.

Science has hitherto been proceeding without the guidance of any rational theory of logic, and has certainly made good progress. It is like a computer who is pursuing some method of arithmetical approximation. Even if he occasionally makes mistakes in his ciphering, yet if the process is a good one they will rectify themselves. But then he would approximate much more rapidly if he did not commit these errors; and in my opinion, the time has come when science ought to be provided with a logic. My theory satisfies me; I can see no flaw in it. According to that theory universality, necessity, exactitude, in the absolute sense of these words, are unattainable by us, and do not exist in nature. There is an ideal law to which nature approximates; but to express it would require an endless series of modifications, like the decimals expressing surd. Only when you have asked a question in so crude a shape that continuity is not involved, is a perfectly true answer attainable.

Science has taught us to think the unthinkable. Because when nature is the guide—rather than a priori prejudices, hopes, fears or desires—we are forced out of our comfort zone. One by one, pillars of classical logic have fallen by the wayside as science progressed in the 20th century, from Einstein's realization that measurements of space and time were not absolute but observer-dependent, to quantum mechanics, which not only put fundamental limits on what we can empirically know but also demonstrated that elementary particles and the atoms they form are doing a million seemingly impossible things at once.

Science is continually correcting what it has said. Fertile corrections... science is a ladder... poetry is a winged flight... An artistic masterpiece exists for all time... Dante does not efface Homer.

Found in David Hatcher Childress and Bill Clendenon, Atlantis & the Power System of the Gods (2002), 191. [Quote may be questionable since no major source found by Webmaster. If you have information on a primary source, please contact Webmaster.]

Sciences usually advances by a succession of small steps, through a fog in which even the most keen-sighted explorer can seldom see more than a few paces ahead. Occasionally the fog lifts, an eminence is gained, and a wider stretch of territory can be surveyed—sometimes with startling results. A whole science may then seem to undergo a kaleidoscopic rearrangement, fragments of knowledge sometimes being found to fit together in a hitherto unsuspected manner. Sometimes the shock of readjustment may spread to other sciences; sometimes it may divert the whole current of human thought.

Scientific progress is the discovery of a more and more comprehensive simplicity... The previous successes give us confidence in the future of science: we become more and more conscious of the fact that the universe is cognizable.

See, thro' this air, this ocean, and this earth,All matter quick, and bursting into birth.Above, how high progressive life may go!Around, how wide! how deep extend below!Vast chain of being, which from God began,Natures ethereal, human, angel, man,Beast, bird, fish, insect! what no eye can see,No glass can reach! from Infinite to thee,From thee to Nothing—On superior pow'rsWere we to press, inferior might on ours:Or in the full creation leave a void,Where, one step broken, the great scale's destroy'd:From Nature's chain whatever link you strike,Tenth or ten thousandth, breaks the chain alike.

Seeing and thinking have done much for human progress; in the sphere of mind and morals everything, and could the world have been saved by armchair philosophy, the Greeks would have done it; but only a novum organon could do this, the powerful possibilities of which were only revealed when man began to search our the secrets of nature by way of experiment, to use the words of Harvey.

Address at the opening of the new Pathological Institute of the Royal Infirmary, Glasgow (4 Oct 1911). Printed in 'The Pathological Institute of a General Hospital', Glasgow Medical Journal (1911), 76, 326.

Since science's competence extends to observable and measurable phenomena, not to the inner being of things, and to the means, not to the ends of human life, it would be nonsense to expect that the progress of science will provide men with a new type of metaphysics, ethics, or religion.

Sir Hermann Bondi once wrote that so-called scientific progress does not consist so much in an advancement in science but rather in taking something that beforehand was not science and making it become a part of science itself.

Someday someone will write a pathology of experimental physics and bring to light all those swindles which subvert our reason, beguile our judgement and, what is worse, stand in the way of any practical progress. The phenomena must be freed once and for all from their grim torture chamber of empiricism, mechanism, and dogmatism; they must be brought before the jury of man's common sense.

That a country, [England], eminently distinguished for its mechanical and manufacturing ingenuity, should be indifferent to the progress of inquiries which form the highest departments of that knowledge on whose more elementary truths its wealth and rank depend, is a fact which is well deserving the attention of those who shall inquire into the causes that influence the progress of nations.

That reminds me to remark, in passing, that the very first official thing I did, in my administration—and it was on the first day of it, too—was to start a patent office; for I knew that a country without a patent office and good patent laws was just a crab, and couldn't travel any way but sideways or backways.

The 'stream' we call science always flows forward; sometimes reactionary beavers block its flow, but the stream is never defeated by this; it accumulates, gathers strength; its waters get over the barrage and continue on their course. The advancement of science is the advancement of God, for science is nothing but human intelligence, and human intelligence is the most valuable treasure God has bequeathed us.

The art of progress is to preserve order amid change and to preserve change amid order. Life refuses to be embalmed alive. The more prolonged the halt in some unrelieved system of order, the greater the crash of the dead society.

The beginning of civilisation is the discovery of some useful arts, by which men acquire property, comforts, or luxuries. The necessity or desire of preserving them leads to laws and social institutions. The discovery of peculiar arts gives superiority to particular nations ... to subjugate other nations, who learn their arts, and ultimately adopt their manners;— so that in reality the origin as well as the progress and improvement of civil society is founded in mechanical and chemical inventions.

The Christians who engaged in infamous persecutions and shameful inquisitions were not evil men but misguided men. The churchmen who felt they had an edict from God to withstand the progress of science, whether in the form of a Copernican revolution or a Darwinian theory of natural selection, were not mischievous men but misinformed men. And so Christ’s words from the cross are written in sharp-edged terms across some of the most inexpressible tragedies of history: 'They know not what they do'.

The Commissioner of Patents may be likened to a wine merchant. He has in his office the wine of human progress of every kind and quality—wine, one may say, produced from the fermentation of the facts of the world through the yeast of human effort. Sometimes the yeast is “wild” and sometimes the “must” is poor, and while it all lies there shining with its due measure of the sparkle of divine effort, it is but occasionally that one finds a wine whose bouquet is the result of a pure culture on the true fruit of knowledge. But it is this true, pure wine of discovery that is alone of lasting significance.

The commissioners of the treasury moved the king, for the relief of his estate, to disafforest some forests of his, explaining themselves of such forests as lay out of the way, not near any of the king’s houses, nor in the course of his progress; whereof he should never have use nor pleasure. “Why,” saith the king, “do you think that Solomon had use and pleasure of all his three hundred concubines?”

In 'A Collection of Apophthegms, New and Old' (1625). As given in Essays, Moral, Economical, and Political: A New Edition, With the Latin Quotations Translated (1813), No. 9, 262. King James I was named in the preceding Apophthegm No. 3.

The comparatively small progress toward universal acceptance made by the metric system seems to be due not altogether to aversion to a change of units, but also to a sort of irrepressible conflict between the decimal and binary systems of subdivision.[Remarking in 1892 (!) that although decimal fractions were introduced about 1585, America retains measurements in halves, quarters, eights and sixteenths in various applications such as fractions of an inch, the compass or used by brokers.]

The day when the scientist, no matter how devoted, may make significant progress alone and without material help is past. This fact is most self-evident in our work. Instead of an attic with a few test tubes, bits of wire and odds and ends, the attack on the atomic nucleus has required the development and construction of great instruments on an engineering scale.

The earth's becoming at a particular period the residence of human beings, was an era in the moral, not in the physical world, that our study and contemplation of the earth, and the laws which govern its animate productions, ought no more to be considered in the light of a disturbance or deviation from the system, than the discovery of the satellites of Jupiter should be regarded as a physical event in the history of those heavenly bodies, however influential they may have become from that time in advancing the progress of sound philosophy among men.

The engineer is the key figure in the material progress of the world. It is his engineering that makes a reality of the potential value of science by translating scientific knowledge into tools, resources, energy and labor to bring them to the service of man ... To make contribution of this kind the engineer requires the imagination to visualize the needs of society and to appreciate what is possible as well as the technological and broad social age understanding to bring his vision to reality.

The essence of modernity is that progress no longer waits on genius; instead we have learned to put our faith in the organized efforts of ordinary men. Science is as old as the race, but the effective organization of science is new. Ancient science, like placer mining, was a pursuit of solitary prospectors. Nuggets of truth were found, but the total wealth of knowledge increased slowly. Modern man began to transform this world when he began to mine the hidden veins of knowledge systematically.

The fact that Science walks forward on two feet, namely theory and experiment, is nowhere better illustrated than in the two fields for slight contributions to which you have done me the great honour of awarding the the Nobel Prize in Physics for the year 1923. Sometimes it is one foot that is put forward first, sometimes the other, but continuous progress is only made by the use of both—by theorizing and then testing, or by finding new relations in the process of experimenting and then bringing the theoretical foot up and pushing it on beyond, and so on in unending alterations.

The formulation of a problem is often more essential than its solution, which may be merely a matter of mathematical or experimental skill. To raise new questions, new possibilities, to regard old problems from a new angle requires creative imagination and marks real advances in science.

The fundamental hypothesis of genetic epistemology is that there is a parallelism between the progress made in the logical and rational organization of knowledge and the corresponding formative psychological processes. With that hypothesis, the most fruitful, most obvious field of study would be the reconstituting of human history—the history of human thinking in prehistoric man. Unfortunately, we are not very well informed in the psychology of primitive man, but there are children all around us, and it is in studying children that we have the best chance of studying the development of logical knowledge, physical knowledge, and so forth.

The gentleman [Mr. Taber] from New York says [agricultural research] is all foolish. Yes; it was foolish when Burbank was experimenting with wild cactus. It was foolish when the Wright boys went down to Kitty Hawk and had a contraption there that they were going to fly like birds. It was foolish when Robert Fulton tried to put a boiler into a sail boat and steam it up the Hudson. It was foolish when one of my ancestors thought the world was round and discovered this country so that the gentleman from New York could become a Congressman. (Laughter.) ... Do not seek to stop progress; do not seek to put the hand of politics on these scientific men who are doing a great work. As the gentleman from Texas points out, it is not the discharge of these particular employees that is at stake, it is all the work of investigation, of research, of experimentation that has been going on for years that will be stopped and lost.

Speaking (28 Dec 1932) as a member of the 72nd Congress, early in the Great Depression, in opposition to an attempt to eliminate a small amount from the agricultural appropriation bill. As quoted in 'Mayor-Elect La Guardia on Research', Science (1933), New Series, 78, No. 2031, 511.

The greater is the circle of light, the greater is the boundary of the darkness by which it is confined. But, notwithstanding this, the more light get, the more thankful we ought to be, for by this means we have the greater range for satisfactory contemplation. time the bounds of light will be still farther extended; and from the infinity of the divine nature, and the divine works, we may promise ourselves an endless progress in our investigation them: a prospect truly sublime and glorious.

The history of science, like the history of all human ideas, is a history of irresponsible dreams, of obstinacy, and of error. But science is one of the very few human activities—perhaps the only one—in which errors are systematically criticized and fairly often, in time, corrected. This is why we can say that, in science, we often learn from our mistakes, and why we can speak clearly and sensibly about making progress there. In most other fields of human endeavour there is change, but rarely progress ... And in most fields we do not even know how to evaluate change.

The idea that the bumps or depressions on a man's head indicate the presence or absence of certain moral characteristics in his mental equipment is one of the absurdities developed from studies in this field that has long since been discarded by science. The ideas of the phrenologist Gall, however ridiculous they may now seem in the light of a century's progress, were nevertheless destined to become metamorphosed into the modern principles of cerebral localization.

The mathematician of to-day admits that he can neither square the circle, duplicate the cube or trisect the angle. May not our mechanicians, in like manner, be ultimately forced to admit that aerial flight is one of that great class of problems with which men can never cope… I do not claim that this is a necessary conclusion from any past experience. But I do think that success must await progress of a different kind from that of invention.[Written following Samuel Pierpoint Langley's failed attempt to launch his flying machine from a catapult device mounted on a barge in Oct 1903. The Wright Brother's success came on 17 Dec 1903.]

The mind God is looking for in man is a doubting, questioning mind, not a dogmatic mind; dogmatic reasoning is wrong reasoning. Dogmatic reason ties a huge rock to a man’s foot and stops him forever from advancing.

The natural scientists of the previous age knew less than we do and believed they were very close to the goal: we have taken very great steps in its direction and now discover we are still very far away from it. With the most rational philosophers an increase in their knowledge is always attended by an increased conviction of their ignorance.

The nineteenth century is a turning point in history, simply on account of the work of two men, Darwin and Renan, the one the critic of the Book of Nature, the other the critic of the books of God. Not to recognise this is to miss the meaning of one of the most important eras in the progress of the world.

The nineteenth century will ever be known as the one in which the influences of science were first fully realised in civilised communities; the scientific progress was so gigantic that it seems rash to predict that any of its successors can be more important in the life of any nation.

Against Method: Outline of an Anarchistic Theory of Knowledge (1975, 1993), 14. In the chapter summary for Chapter 1.

The present rate of progress [in X-ray crystallography] is determined, not so much by the lack of problems to investigate or the limited power of X-ray analysis, as by the restricted number of investigators who have had a training in the technique of the new science, and by the time it naturally takes for its scientific and technical importance to become widely appreciated.

Concluding remark in Lecture (1936) on 'Forty Years of Crystal Physics', collected in Needham and Pagel (eds.) in Background to Modern Science: Ten Lectures at Cambridge Arranged by the History of Science Committee, (1938), 89.

The presentation of mathematics where you start with definitions, for example, is simply wrong. Definitions aren't the places where things start. Mathematics starts with ideas and general concepts, and then definitions are isolated from concepts. Definitions occur somewhere in the middle of a progression or the development of a mathematical concept. The same thing applies to theorems and other icons of mathematical progress. They occur in the middle of a progression of how we explore the unknown.

The progress of Science consists in observing interconnections and in showing with a patient ingenuity that the events of this ever-shifting world are but examples of a few general relations, called laws. To see what is general in what is particular, and what is permanent in what is transitory, is the aim of scientific thought.

The progress of science depends less than is usually believed on the efforts and performance of the individual genius ... many important discoveries have been made by men of ordinary talents, simply because chance had made them, at the proper time and in the proper place and circumstances, recipients of a body of doctrines, facts and techniques that rendered almost inevitable the recognition of an important phenomenon. It is surprising that some historian has not taken malicious pleasure in writing an anthology of 'one discovery' scientists. Many exciting facts have been discovered as a result of loose thinking and unimaginative experimentation, and described in wrappings of empty words. One great discovery does not betoken a great scientist; science now and then selects insignificant standard bearers to display its banners.

The progress of science has always been the result of a close interplay between our concepts of the universe and our observations on nature. The former can only evolve out of the latter and yet the latter is also conditioned greatly by the former. Thus in our exploration of nature, the interplay between our concepts and our observations may sometimes lead to totally unexpected aspects among already familiar phenomena.

The progress of science is often affected more by the frailties of humans and their institutions than by the limitations of scientific measuring devices. The scientific method is only as effective as the humans using it. It does not automatically lead to progress.

The progress of synthesis, or the building up of natural materials from their constituent elements, proceeds apace. Even some of the simpler albuminoids, a class of substances of great importance in the life process, have recently been artificially prepared. ... Innumerable entirely new compounds have been produced in the last century. The artificial dye-stuffs, prepared from materials occurring in coal-tar, make the natural colours blush. Saccharin, which is hundreds of times sweeter than sugar, is a purely artificial substance. New explosives, drugs, alloys, photographic substances, essences, scents, solvents, and detergents are being poured out in a continuous stream.

The purpose of the history of science is to establish the genesis and the development of scientific facts and ideas, taking into account all intellectual exchanges and all influences brought into play by the very progress of civilization. It is indeed a history of civilization considered from its highest point of view. The center of interest is the evolution of science, but general history remains always in the background.

The scientific doctrine of progress is destined to replace not only the myth of progress, but all other myths of human earthly destiny. It will inevitably become one of the cornerstones of man's theology, or whatever may be the future substitute for theology, and the most important external support for human ethics.

The scientific enterprise is full of experts on specialist areas but woefully short of people with a unified worldview. This state of affairs can only inhibit progress, and could threaten political and financial support for research.

The specific qualities in diseases also tend more rapidly to the skin than to the deeper-seated parts, except the cancer; although even in this disease the progress towards the superficies is more quick than its progress towards the centre. In short, this is a law in nature, and it probably is upon the same principle by which vegetables always approach the surface of the earth.

The steady progress of physics requires for its theoretical formulation a mathematics which get continually more advanced. ... it was expected that mathematics would get more and more complicated, but would rest on a permanent basis of axioms and definitions, while actually the modern physical developments have required a mathematics that continually shifts its foundation and gets more abstract. Non-euclidean geometry and noncommutative algebra, which were at one time were considered to be purely fictions of the mind and pastimes of logical thinkers, have now been found to be very necessary for the description of general facts of the physical world. It seems likely that this process of increasing abstraction will continue in the future and the advance in physics is to be associated with continual modification and generalisation of the axioms at the base of mathematics rather than with a logical development of any one mathematical scheme on a fixed foundation.

Introduction to a paper on magnetic monopoles, 'Quantised singularities in the electromagnetic field', Proceedings of the Royal Society of Lonndon (1931), A, 133 60. In Helge Kragh, Dirac: a Scientific Biography (1990), 208.

The test of a theory is its ability to cope with all the relevant phenomena, not its a priori 'reasonableness'. The latter would have proved a poor guide in the development of science, which often makes progress by its encounter with the totally unexpected and initially extremely puzzling.

The thesis which I venture to sustain, within limits, is simply this, that the savage state in some measure represents an early condition of mankind, out of which the higher culture has gradually been developed or evolved, by processes still in regular operation as of old, the result showing that, on the whole, progress has far prevailed over relapse.

Theories cannot claim to be indestructible. They are only the plough which the ploughman uses to draw his furrow and which he has every right to discard for another one, of improved design, after the harvest. To be this ploughman, to see my labours result in the furtherance of scientific progress, was the height of my ambition, and now the Swedish Academy of Sciences has come, at this harvest, to add the most brilliant of crowns.

There can be no thought of finishing, for aiming at the stars, both literally and figuratively, is the work of generations, but no matter how much progress one makes there is always the thrill of just beginning.

There has never been an age so full of humbug. Humbug everywhere, even in science. For years now the scientists have been promising us every morning a new miracle, a new element, a new metal, guaranteeing to warm us with copper discs immersed in water, to feed us with nothing, to kill us at no expense whatever on a grand scale, to keep us alive indefinitely, to make iron out of heaven knows what. And all this fantastic, scientific humbugging leads to membership of the Institut, to decorations, to influence, to stipends, to the respect of serious people. In the meantime the cost of living rises, doubles, trebles; there is a shortage of raw materials; even death makes no progress—as we saw at Sebastopol, where men cut each other to ribbons—and the cheapest goods are still the worst goods in the world.With co-author Jules de Goncourt (French writer, 1830-70)

Thus with every advance in our scientific knowledge new elements come up, often forcing us to recast our entire picture of physical reality. No doubt, theorists would much prefer to perfect and amend their theories rather than be obliged to scrap them continually. But this obligation is the condition and price of all scientific progress.

To conclude, therefore, let no man out of a weak conceit of sobriety, or an ill-apply'd moderation, think or maintain, that a man can search too far or be too well studied in the book of God’s word, or in the book of God’s works; divinity or philosophy; but rather let men endeavour an endless progress or proficience in both.

In Of Proficience and Advancement of Learning Divine and Human (1605), collected in The Works of Francis Bacon (1711), Vol. 2, 417. Charles Darwin placed this quote on the title page of his On the Origin of Species.

Truth travels down from the heights of philosophy to the humblest walks of life, and up from the simplest perceptions of an awakened intellect to the discoveries which almost change the face of the world. At every stage of its progress it is genial, luminous, creative. When first struck out by some distinguished and fortunate genius, it may address itself only to a few minds of kindred power. It exists then only in the highest forms of science; it corrects former systems, and authorizes new generalizations. Discussion, controversy begins; more truth is elicited, more errors exploded, more doubts cleared up, more phenomena drawn into the circle, unexpected connexions of kindred sciences are traced, and in each step of the progress, the number rapidly grows of those who are prepared to comprehend and carry on some branches of the investigation,— till, in the lapse of time, every order of intellect has been kindled, from that of the sublime discoverer to the practical machinist; and every department of knowledge been enlarged, from the most abstruse and transcendental theory to the daily arts of life.

Tungsten, X-rays, and Coolidge form a trinity that has left an indelible impression upon our life and times. The key word in this triad is Coolidge, for his work brought the element tungsten from laboratory obscurity to the central role of the industrial stage and gave the X-ray a central role in the progress of medicine throughout the world.

Twenty centuries of 'progress' have brought the average citizen a vote, a national anthem, a Ford, a bank account, and a high opinion of himself, but not the capacity to live in high density without befouling and denuding his environment, nor a conviction that such capacity, rather than such density, is the true test of whether he is civilized.

Upon the whole, Chymistry is as yet but an opening science, closely connected with the usefull and ornamental arts, and worthy the attention of the liberal mind. And it must always become more and more so: for though it is only of late, that it has been looked upon in that light, the great progress already made in Chymical knowledge, gives us a pleasant prospect of rich additions to it. The Science is now studied on solid and rational grounds. While our knowledge is imperfect, it is apt to run into error: but Experiment is the thread that will lead us out of the labyrinth.

We are compelled to drive toward total knowledge, right down to the levels of the neuron and the gene. When we have progressed enough to explain ourselves in these mechanistic terms...the result might be hard to accept.

We are going through the body-snatching phase right now, and there are all these Burke and Hare attitudes towards geneticists-that they are playing God and that DNA is sacred. No, it's not. It's no more sacred than your toenails. Basically, we are not going to make long-term medical progress without understanding how the genes work.[Referring to the similarity of fears and superstitions in genetics as once were associated with anatomy ]

We are like dwarfs [the moderns] sitting on the shoulders of giants [the ancients]. Our glance can thus take in more things and reach farther than theirs. It is not because our sight is sharper nor our height greater than theirs; it is that we are carried and elevated by the high stature of the giants.

We cannot see how the evidence afforded by the unquestioned progressive development of organised existence—crowned as it has been by the recent creation of the earth's greatest wonder, MAN, can be set aside, or its seemingly necessary result withheld for a moment. When Mr. Lyell finds, as a witty friend lately reported that there had been found, a silver-spoon in grauwacke, or a locomotive engine in mica-schist, then, but not sooner, shall we enrol ourselves disciples of the Cyclical Theory of Geological formations.

We do not live in a time when knowledge can be extended along a pathway smooth and free from obstacles, as at the time of the discovery of the infinitesimal calculus, and in a measure also when in the development of projective geometry obstacles were suddenly removed which, having hemmed progress for a long time, permitted a stream of investigators to pour in upon virgin soil. There is no longer any browsing along the beaten paths; and into the primeval forest only those may venture who are equipped with the sharpest tools.

We have found that where science has progressed the farthest, the mind has but regained from nature that which the mind has put into nature.We have found a strange foot-print on the shores of the unknown. We have devised profound theories, one after another, to account for its origin. At last, we have succeeded in reconstructing the creature that made the foot-print. And Lo! it is our own.

We may, I think, draw a yet higher and deeper teaching from the phenomena of degeneration. We seem to learn from it the absolute necessity of labour and effort, of struggle and difficulty, of discomfort and pain, as the condition of all progress, whether physical or mental, and that the lower the organism the more need there is of these ever-present stimuli, not only to effect progress, but to avoid retrogression. And if so, does not this afford us the nearest attainable solution of the great problem of the origin of evil? What we call evil is the essential condition of progress in the lower stages of the development of conscious organisms, and will only cease when the mind has become so thoroughly healthy, so well balanced, and so highly organised, that the happiness derived from mental activity, moral harmony, and the social affections, will itself be a sufficient stimulus to higher progress and to the attainment of a more perfect life.

We must not overlook the role that extremists play. They are the gadflies that keep society from being too complacent or self-satisfied; they are, if sound, the spearhead of progress. If they are fundamentally wrong, free discussion will in time put an end to them.

We see not only thought as participating in evolution as an anomaly or as an epiphenomenon; but evolution as so reducible to and identifiable with a progress towards thought that the movement of our souls expresses and measures the very stages of progress of evolution itself. Man discovers that he is nothing else than evolution become conscious of itself.

We set sail on this new sea because there is new knowledge to be gained, and new rights to be won, and they must be won and used for the progress of all people. For space science, like nuclear science and technology, has no conscience of its own. Whether it will become a force for good or ill depends on man, and only if the United States occupies a position of preeminence can we help decide whether this new ocean will be a sea of peace or a new terrifying theater of war.

What has been done is little—scarcely a beginning; yet it is much in comparison with the total blank of a century past. And our knowledge will, we are easily persuaded, appear in turn the merest ignorance to those who come after us. Yet it is not to be despised, since by it we reach up groping to touch the hem of the garment of the Most High.

What progress individuals could make, and what progress the world would make, if thinking were given proper consideration! It seems to me that not one man in a thousand appreciates what can be accomplished by training the mind to think.

When the mathematician says that such and such a proposition is true of one thing, it may be interesting, and it is surely safe. But when he tries to extend his proposition to everything, though it is much more interesting, it is also much more dangerous. In the transition from one to all, from the specific to the general, mathematics has made its greatest progress, and suffered its most serious setbacks, of which the logical paradoxes constitute the most important part. For, if mathematics is to advance securely and confidently, it must first set its affairs in order at home. [Coauthor with James R. Newman]

Whereas the man of action binds his life to reason and its concepts so that he will not be swept away and lost, the scientific investigator builds his hut right next to the tower of science so that he will be able to work on it and to find shelter for himself beneath those bulwarks which presently exist.

Whereas there is nothing more necessary for promoting the improvement of Philosophical Matters, than the communicating to such, as apply their Studies and Endeavours that way, such things as are discovered or put in practice by others; it is therefore thought fit to employ the Press, as the most proper way to gratifie those, whose engagement in such Studies, and delight in the advancement of Learning and profitable Discoveries, doth entitle them to the knowledge of what this Kingdom, or other parts of the World, do, from time to time, afford as well of the progress of the Studies, Labours, and attempts of the Curious and learned in things of this kind, as of their compleat Discoveries and performances: To the end, that such Productions being clearly and truly communicated, desires after solid and usefull knowledge may be further entertained, ingenious Endeavours and Undertakings cherished, and those, addicted to and conversant in such matters, may be invited and encouraged to search, try, and find out new things, impart their knowledge to one another, and contribute what they can to the Grand design of improving Natural knowledge, and perfecting all Philosophical Arts, and Sciences. All for the Glory of God, the Honour and Advantage of these Kingdoms, and the Universal Good of Mankind.

While the law [of competition] may be sometimes hard for the individual, it is best for the race, because it insures the survival of the fittest in every department. We accept and welcome, therefore, as conditions to which we must accommodate ourselves, great inequality of environment, the concentration of business, industrial and commercial, in the hands of a few, and the law of competition between these, as being not only beneficial, but essential for the future progress of the race.

Within a hundred years of physical and chemical science, men will know what the atom is. It is my belief when science reaches this stage, God will come down to earth with His big ring of keys and will say to humanity, 'Gentlemen, it is closing time.'

Without preparing fluorine, without being able to separate it from the substances with which it is united, chemistry has been able to study and to analyze a great number of its compounds. The body was not isolated, and yet its place was marked in our classifications. This well demonstrates the usefulness of a scientific theory, a theory which is regarded as true during a certain time, which correlates facts and leads the mind to new hypotheses, the first causes of experimentation; which, little by little, destroy the theory itself, in order to replace it by another more in harmony with the progress of science.[Describing the known history of fluorine compounds before his isolation of the element.]

'Fluorine', lecture at the Royal Institution (28 May 1897), translated from the French, in Proceedings of the Royal Institution (1897). In Annual Report of the Board of Regents of the Smithsonian Institution to July 1897 (1898), 262.

You can hardly convince a man of error in a life-time, but must content yourself with the reflection that the progress of science is slow. If he is not convinced, his grand-children may be. The geologists tell us that it took one hundred years to prove that fossils are organic, and one hundred and fifty more, to prove that they are not to be referred to the Noachian deluge.

You don't think progress goes in a straight line, do you? Do you recognize that it is an ascending, accelerating, maybe even exponential curve? It takes hell's own time to get started, but when it goes it goes like a bomb.

In Juanita Rose Violini, Almanac of the Infamous, the Incredible, and the Ignored (2009), 56. If you know a primary source, please contact Webmaster, who has not yet found a primary source for this quote, although seen widely attributed to Will Rogers.

Your remarks upon chemical notation with the variety of systems which have arisen, &c., &c., had almost stirred me up to regret publicly that such hindrances to the progress of science should exist. I cannot help thinking it a most unfortunate thing that men who as experimentalists & philosophers are the most fitted to advance the general cause of science & knowledge should by promulgation of their own theoretical views under the form of nomenclature, notation, or scale, actually retard its progress.

Letter to William Whewell (21 Feb 1831). In Isaac Todhunter, William Whewell, An Account of his Writings (1876), Vol. 1., 307. Faraday may have been referring to a paper by Whewell published in the Journal of the Royal Institution of England (1831), 437-453.

[Euclid's Elements] has been for nearly twenty-two centuries the encouragement and guide of that scientific thought which is one thing with the progress of man from a worse to a better state. The encouragement; for it contained a body of knowledge that was really known and could be relied on, and that moreover was growing in extent and application. For even at the time this book was written—shortly after the foundation of the Alexandrian Museum—Mathematics was no longer the merely ideal science of the Platonic school, but had started on her career of conquest over the whole world of Phenomena. The guide; for the aim of every scientific student of every subject was to bring his knowledge of that subject into a form as perfect as that which geometry had attained. Far up on the great mountain of Truth, which all the sciences hope to scale, the foremost of that sacred sisterhood was seen, beckoning for the rest to follow her. And hence she was called, in the dialect of the Pythagoreans, ‘the purifier of the reasonable soul.’

[No one will be able to] deter the scientific mind from probing into the unknown any more than Canute could command the tides.Comment upon the U.S. Supreme Court's 1980 decision permitting the patenting of life forms.

[The ancient monuments] were all dwarfs in size and pigmies in spirit beside this mighty Statue of Liberty, and its inspiring thought. Higher than the monument in Trafalgar Square which commemorates the victories of Nelson on the sea; higher than the Column Vendome, which perpetuates the triumphs of Napoleon on the land; higher than the towers of the Brooklyn Bridge, which exhibit the latest and greatest results of science, invention, and industrial progress, this structure rises toward the heavens to illustrate an idea ... which inspired the charter in the cabin of the Mayflower and the Declaration of Independence from the Continental Congress.

[The infinitely small] neither have nor can have theory; it is a dangerous instrument in the hands of beginners [ ... ] anticipating, for my part, the judgement of posterity, I would dare predict that this method will be accused one day, and rightly, of having retarded the progress of the mathematical sciences.

[The Whig interpretation of history] ... is the tendency in many historians to write on the side of Protestants and Whigs, to praise revolutions provided they have been successful, to emphasise certain principles of progress in the past and to produce a story which is the ratification if not the glorification of the present.

[To the cultures of Asia and the continent of Africa] it is the Western impact which has stirred up the winds of change and set the processes of modernization in motion. Education brought not only the idea of equality but also another belief which we used to take for granted in the West—the idea of progress, the idea that science and technology can be used to better human conditions. In ancient society, men tended to believe themselves fortunate if tomorrow was not worse than today and anyway, there was little they could do about it.

[To] mechanical progress there is apparently no end: for as in the past so in the future, each step in any direction will remove limits and bring in past barriers which have till then blocked the way in other directions; and so what for the time may appear to be a visible or practical limit will turn out to be but a bend in the road.

In science it often happens that scientists say, 'You know that's a really good argument; my position is mistaken,' and then they would actually change their minds and you never hear that old view from them again. They really do it. It doesn't happen as often as it should, because scientists are human and change is sometimes painful. But it happens every day. I cannot recall the last time something like that happened in politics or religion.
(1987) -- Carl Sagan