Reliability research on machining center has great significance for the quality improvement of the machining center and its mechanical products. The long cycle and insufficient accuracy of collecting data is the main problem of the current reliability research on machining center. By means of building a test-bed and simulating the environment and running conditions of live using in the specialized laboratory, the simulation reliability tests, accelerated and enhancement tests are carried out. This paper aims to solve the above mentioned limitations and offer a more effective method for reliability tests on machining center.