The game, which will kick off at 5:00 p.m. UK time (1:00 p.m. ET), will mark the first in London for the Jaguars, who earlier this year committed to play one regular-season home game in the United Kingdom in 2013, 2014, 2015, and 2016, all at Wembley.

"By committing to play a regular-season home game in London in each of the next four years, the Jaguars will play a major role in helping grow our sport in the UK and beyond," said NFL Commissioner Roger Goodell. "We think Jaguars-49ers is a matchup our fans will really enjoy and a great way to start a new era in the international development of our game."

"Everyone associated with the Jacksonville Jaguars is very much looking forward to our four home games in London through 2016, and we're particularly thrilled and honored that our first opponent will be the San Francisco 49ers," Khan said. "This is a unique and important opportunity for the Jaguars franchise, as well as for our fans and community. To share this stage in our first year at Wembley with a rising power like the 49ers will bring additional attention and respect to what we're trying to achieve as a franchise. We can't wait to see our global vision for the Jaguars become reality next season."