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Epigenetics and aging

Aging is a multifaceted process characterized by genetic and epigenetic changes in the genome. However, epigenetic mechanisms have now emerged as key contributors to the alterations of genome structure and function that accompany aging. The epigenetic mark that has been most highly studied is DNA methylation. In this review, we focus on healthy human aging throughout lifetime and discuss dynamics of DNA methylation as well as how interactions between the genome, environment and the epigenome influence aging rates.