Llution. O. dioica can be kept in culture for many generations and has a very short generation time (6 days at 15 ) [8]. Although tunicates are the closest living relatives of vertebrates [9], a recent study revealed profound divergence of genome architecture features in Oikopleura [10]. Its gene complement may have also markedly changed with multiple examples of ancestral genes failing detection,

Llution. O. dioica can be kept in culture for many generations and has a very short generation time (6 days at 15 ) [8]. Although tunicates are the closest living relatives of vertebrates [9], a recent study revealed profound divergence of genome architecture features in Oikopleura [10]. Its gene complement may have also markedly changed with multiple examples of ancestral genes failing detection,

Llution. O. dioica can be kept in culture for many generations and has a very short generation time (6 days at 15 ) [8]. Although tunicates are the closest living relatives of vertebrates [9], a recent study revealed profound divergence of genome architecture features in Oikopleura [10]. Its gene complement may have also markedly changed with multiple examples of ancestral genes failing detection,

Isons of genomes from distantly related metazoans suggest conservation of the chemical defensome [1-3]. Oikopleura dioica belongs to larvacean tunicates that have considerable importance in the marine ecosystem and for the vertical flux of carbon in the* Correspondence: daniel.chourrout@sars.uib.no 1 Sars International Centre for Marine Molecular Biology, University of Bergen, Bergen, Norway Full

Isons of genomes from distantly related metazoans suggest conservation of the chemical defensome [1-3]. Oikopleura dioica belongs to larvacean tunicates that have considerable importance in the marine ecosystem and for the vertical flux of carbon in the* Correspondence: daniel.chourrout@sars.uib.no 1 Sars International Centre for Marine Molecular Biology, University of Bergen, Bergen, Norway Full

Ro-fibrils. This was suggested to be crucial for HA mineral nucleation [59]. Self-assembly is thus another way that the IDP proteins can regulate the process of biomineralization.Author Manuscript Author Manuscript Author Manuscript Author Manuscript3. Potential Mechanisms of IDP Action: BiomineralizationThere must be precise reasons why so many IDP proteins are associated with mineralization. It

Arbon benzo[a]pyrene (BaP) the pharmaceutical compound Clofibrate (Clo). Results: Oikopleura genome surveys for key genes of the chemical defensome suggested a reduced repertoire. Not more than 23 cytochrome P450 (CYP) genes could be identified, and neither CYP1 family genes nor their transcriptional activator AhR was detected. These two genes were present in deuterostome ancestors. As in vertebra

Arbon benzo[a]pyrene (BaP) the pharmaceutical compound Clofibrate (Clo). Results: Oikopleura genome surveys for key genes of the chemical defensome suggested a reduced repertoire. Not more than 23 cytochrome P450 (CYP) genes could be identified, and neither CYP1 family genes nor their transcriptional activator AhR was detected. These two genes were present in deuterostome ancestors. As in vertebra