Other causes of ankle rashes may be stress or anxiety, Golfer’s vasculitis, heat, varicose veins and excessive methamphetamine use, states Healthgrades. An ankle rash may also be a symptom of a life-threatening condition such as anaphylaxis, erythema multiforme and toxic epidermal necrolysis. Erythema multiforme is a type of severe allergic reaction, and toxic epidermal necrolysis is the loss of skin and mucosal due to a reaction to medication.

In addition to redness, symptoms of an ankle rash include pain, blisters, a change in skin texture, dry skin and itching, says Healthgrades. Other symptoms are inflammation, an accompanying rash on the legs, and flaking or peeling skin. Certain ankle rashes may cause symptoms in other parts of the body, such as joint pain, a decreased appetite, flu-like symptoms and red eyes.