After a short overlap with US 460 Business, SR 40 leaves to the east, while the business route continues northeast back to US 460. Because SR 40 is south of US 460 Business on both sides of the overlap, SR 40 does not intersect US 460 here. Outside the town limits, SR 40 crosses through Fort Pickett. The route crosses US 1 in McKenney and I-85 at exit 42 just to the east. After bypassing Stony Creek to the south, SR 40 crosses US 301 and I-95 at exit 31; a short State Route 40 Business follows the original route through Stony Creek, returning to SR 40 on the east end via a short overlap with US 301. Between Sussex and a point east of Homeville (where SR 40 crosses SR 35), a secondary route to the south is the former alignment, now named Old Forty Road. Beyond Homeville, the last stretch of the highway heads northeasterly, crossing US 460 in Waverly before ending at SR 10 at Spring Grove. State Route 646, a secondary highway, continues northeast beyond SR 10 to the former end of SR 40 in Claremont.[2]

Virginia State Truck Route 40 in Victoria, Virginia is Tidewater Avenue from Court Street to West 6th Street, and Railroad Avenue from Tidewater Avenue and West 6th Street to Main Street. Most of the route is concurrent with Virginia State Route 49 Truck

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State Route 40 Business is a former segment of SR 40 that was converted into a business route that runs through "downtown" Stony Creek. It runs along Lee Avenue from a realigned section of SR 40 west of the town, crosses a CSX railroad line and then turns south in a multiplex with US 301(Blue Star Memorial Highway), where it ends at SR 40 west of Exit 31 on Interstate 95. US 301 continues from here south towards Emporia, the Carolinas, Georgia, and northern and western Florida.

This section needs expansion. You can help by adding to it.(August 2014)