Purpose: :
To pool CSLO data from the OHTS and the EGPS to improve theprediction of the development of POAG in ocular hypertensivesubjects.

Methods: :
222 subjects with good quality Heidelberg Retina Tomograph (HRT)images from the observation group of the CSLO Ancillary Studyto the OHTS and 229 subjects from the EGPS placebo group wereincluded. Based on stringent statistical testing to determineif pooling the studies was appropriate, the data from the twostudies was judged to be appropriate for pooling. The abilityof global and sectoral neuroretinal rim, optic cup and retinalnerve fiber layer parameters to predict the development of POAGwere evaluated in multivariable models adjusting for age, IOP,central corneal thickness and HRT disc area.

Conclusions: :
The OHTS CSLO predictive model was validated in the EGPS placebogroup. These results strengthen the evidence that CSLO measurementscan be used in models to predict the onset of POAG in patientswith ocular hypertension.