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The distinction of metabolically ‘healthy’ from ‘unhealthy’ obese individuals

Blüher, Matthias

Abstract

Purpose of review: The prevalence and severity of obesity are dramatically increasing throughout the world. Obesity causes a decline in life expectancy due to its associated metabolic and cardiovascular comorbid disorders. Therefore, it will become more important to distinguish obese individuals at high risk for obesity-related metabolic diseases from those who are metabolically ‘healthy’. This review focuses on recent evidence suggesting that normal adipose tissue function contributes to the healthy obese phenotype.

Summary: Recommendations for obesity treatment should distinguish the metabolically ‘healthy’ from ‘unhealthy’ obese phenotype to identify early the obese person who will benefit the most from losing weight. In addition, novel antiobesity treatment strategies targeting adipose tissue dysfunction are needed.

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