Roy Wise was born on November 18, 1923, in Springfield, IL. Wise was 20 years old when he broke into the big leagues on May 12, 1944, with the Pittsburgh Pirates. He appeared in two games with the Pirates, pitched three innings, gave up four hits and three base-on-balls with three earned runs for a 9.00 ERA. He had no decisions in his two appearances. He was released on June 29th by the Pirates.