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Abstract:

IL-36 cytokines require proteolytic
processing for activation, but how this is
achieved is unknown. Here, Henry et al.
show that proteases liberated from
activated neutrophils—cathepsin G,
elastase, and proteinase-3—differentially
process and activate all three IL-36 family
members. Therefore, neutrophil-derived
proteases can escalate inflammation
through processing of extracellular
cytokines.