Cleveland Police said officers are concerned for Mr Hussain as he is due medication which he does not have with him.

He was last seen wearing a grey hooded top with Air Max on the rear, a black t-shirt, grey jogging bottoms and Nike Air-Max trainers. He may also have a black adidas jacket with white sleeves and gold stripes down the sleeves.

He is described as 6ft tall, medium build with shaved hair and a 2cm birthmark on the back of his hand.

A spokeswoman for Cleveland Police said: "Mr Hussain has links to London, Manchester, Nottingham and Derby and could have travelled to one of these locations on the train.

"He could be in the Cleveland area, so social media users are being asked to share his picture and information far and wide.

"Anyone with information on his whereabouts is asked to call Cleveland Police on the non-emergency number 101."