Dr. Bernd Wollscheid

Main Goals, Keywords

Dr. Bernd Wollscheid and his
research group are focusing on the development of a qualitative and
quantitative understanding of the cellular surfaceome as a complex information
gateway to the microenvironment. Further information about our research topics
can be found here: Google Scholar / PubMed.

Group Members

1 group leader, 1 PostDoc, 4 PhD
students, 1 project/lab manager

Previous and Current Research

The molecular composition and
dynamic organization of the plasma membrane (PM) determines how a cell can
interact with its environment at any given moment. Cell surface proteins are
crucial for cell-cell communication, interaction with pathogens, binding of
chemical messengers, and responding to environmental perturbations. Alterations
in the PM protein composition, as a result of a disease may well define
phenotypic and functional differences between normal, and for example tumour
cells. Cell surface proteins can be markers of disease and are potential
targets for pharmaceutical intervention. The goals of our research group are:

To develop new methodologies for
the specific labeling of proteins residing in the plasma membrane

In order to achieve these goals,
we are utilizing state-of-the-art quantitative chemoproteomic tools in
combination with fluorescence activated cell sorting technology, molecular imaging
techniques and bioinformatic tools.

Future Projects

Deciphering the extracellular interactome: Many to
many interactions and how they influence cellular states. · Host-pathogen interactions: How
pathogens hijack cellular communication pathways. Please contact me (wbernd@ethz.ch) directly
for details about these projects.

Deciphering the extracellular interactome: Many to
many interactions and how they influence cellular states.

Important Note:
The content in this site is accessible to any browser or
Internet device, however, some graphics will display correctly
only in the newer versions of Netscape. To get the most out of
our site we suggest you upgrade to a newer browser.More
information