Wang, MA

Baitao Wang, Belchertown, MA US

Patent application number

Description

Published

20090273190

Asymmetric hydraulic press electric generator - The asymmetric hydraulic press electric generator is a device that converts mechanical energy to electrical energy using hydraulic pressure. It employs the principle that force acting on a small area can create a much larger force by virtue of hydrostatic pressure and that a large amount of energy can be carried by a small flow of highly pressurized fluid.

11-05-2009

Bingnan Wang, Boston, MA US

Patent application number

Description

Published

20110133564

Wireless Energy Transfer with Negative Index Material - Embodiments of the invention disclose a system configured to exchange energy wirelessly. The system includes a structure configured to exchange the energy wirelessly via a coupling of evanescent waves, wherein the structure is electromagnetic (EM) and non-radiative, and wherein the structure generates an EM near-field in response to receiving the energy; and a negative index material (NIM) arranged within the EM near-field such that the coupling is enhanced.

06-09-2011

20110133565

Wireless Energy Transfer with Negative Index Material - Embodiments of the invention disclose a system configured to exchange energy wirelessly. The system includes a structure configured to exchange the energy wirelessly via a coupling of evanescent waves, wherein the structure is electromagnetic (EM) and non-radiative, and wherein the structure generates an EM near-field in response to receiving the energy; and a negative index material (NIM) arranged within the EM near-field such that the coupling is enhanced.

06-09-2011

20110133566

Wireless Energy Transfer with Negative Material - Embodiments of the invention disclose a system configured to exchange energy wirelessly. The system includes a structure configured to exchange the energy wirelessly via a coupling of evanescent waves, wherein the structure is electromagnetic (EM) and non-radiative, and wherein the structure generates an EM near-field in response to receiving the energy; and a negative index material (NIM) arranged within the EM near-field such that the coupling is enhanced.

06-09-2011

20110133568

Wireless Energy Transfer with Metamaterials - Embodiments of the invention disclose a system configured to exchange energy wirelessly. The system includes a structure configured to exchange the energy wirelessly via a coupling of evanescent waves, wherein the structure is electromagnetic (EM) and non-radiative, and wherein the structure generates an EM near-field in response to receiving the energy; and a metamaterial arranged within the EM near-field such that the coupling is enhanced.

06-09-2011

20120038219

Wireless Energy Transfer with Anisotropic Metamaterials - Embodiments of the invention disclose a system configured to exchange energy wirelessly. The system includes a structure configured to exchange the energy wirelessly via a coupling of evanescent waves, wherein the structure is electromagnetic (EM) and non-radiative, and wherein the structure generates an EM near-field in response to receiving the energy; and an anisotropic metamaterial arranged within the EM near-field such that the coupling is enhanced.

02-16-2012

20120080956

Wireless Energy Transfer Using Array of Resonant Objects - A system for exchanging energy wirelessly comprises an array of at least three objects having a resonant frequency, each object is electromagnetic (EM) and non-radiative, and generates an EM near-field in response to receiving the energy, wherein each object in the array is arranged at a distance from all other objects in the array, such that upon receiving the energy the object is strongly coupled to at least one other object in the array via a resonant coupling of evanescent waves; and an energy driver for providing the energy at the resonant frequency to at least one object in the array, such that, during an operation of the system, the energy is distributed from the object to all other objects in the array.

04-05-2012

20120217816

Wireless Energy Transfer Using Arrays of Resonant Objects - A system for exchanging energy wirelessly includes an array of at least three objects, wherein the objects have similar resonant frequencies, wherein each object is electromagnetic (EM) and non-radiative and generates an EM near-field in response to receiving the energy. Each object is electrically isolated from the other objects and arranged at a distance from all other objects, such that upon receiving the energy, the object is strongly coupled to at least one other object via a resonant coupling of evanescent waves. An energy driver provides the energy at the resonant frequency to at least one object in the array, such that, during an operation of the system, the energy is distributed from the at least one object to all other objects in the array via the resonant coupling of the evanescent waves.

08-30-2012

20120217817

Tuning Electromagnetic Fields Characteristics for Wireless Energy Transfer Using Arrays of Resonant Objects - A system for exchanging energy wirelessly includes an array of objects, wherein each object is electromagnetic (EM) and non-radiative and generates an EM near-field in response to receiving the energy. Each object in the array is electrically isolated from the other objects and arranged at a distance from all other objects. An energy driver provides the energy to the array of objects. A receiver, at a relative position with respect to the array receives the energy via resonant coupling of evanescent waves. The system can tunes characteristics of the EM near-field depending on a relative position of the receiver with respect to the array. The tuning can affect frequency, phase and amplitude of the energy field.

08-30-2012

20120217818

System and Method for Automatically Optimizing Wireless Power - A system transfers energy wirelessly from a source to a sink as an EM near-field according to parameters. The source includes a receive RF chain, and a receive controller. The sink includes a transmit RF chain, and a receive controller. The receive controller measures the energy received as feedback information, which is transmitted to the sink. Then, the transmit controller dynamically varies the parameters to optimized the energy received at the sink.

08-30-2012

20130127252

Wireless Energy Transfer with Perfect Magnetic Conductors - A system that transfers energy wirelessly includes a transmitter of the energy and a receiver of the energy. A housing made of a material that approximates properties of a perfect magnetic conductor. The housing is arranged to direct a magnetic field from the transmitter to the receiver to improve an efficiency of the energy transfer from the transmitter to the receiver.

05-23-2013

20130140908

Wireless Energy Transfer with Metamaterials - Embodiments of the invention disclose a system configured to exchange energy wirelessly. The system includes a structure configured to exchange the energy wirelessly via a coupling of evanescent waves, wherein the structure is electromagnetic (EM) and non-radiative, and wherein the structure generates an EM near-field in response to receiving the energy; and a metamaterial arranged within the EM near-field such that the coupling is enhanced.

06-06-2013

20130144588

System and Method for Analyzing Spiral Resonators - A spiral resonator is analyzed by modeling a set of loops of the spiral resonator with a model of a circuit including a set of units, wherein each unit includes a resistor and an inductor to model one loop of the spiral resonator. Values of the resistor and the inductor of each unit are based on properties of a corresponding loop. Electrical connection of the loops is modeled by electrically connecting the units in a corresponding order of the loops. A capacitive coupling in the spiral resonator is modeled by connecting adjacent units with at least one capacitor having a value based on the capacitive coupling between two corresponding adjacent loops. An inductive coupling in the spiral resonator is modeled based on inductive coupling between pairs of loops. The operation of the spiral resonator is simulated with the model of the circuit.

06-06-2013

20130156361

Mode-Evolution Compound Converter - A mode-evolution compound converter for processing an optical signal that includes a first component having a fundamental transverse magnetic (TM) mode and a second component having a fundamental transverse electric (TE) mode is disclosed. The compound converter includes a set of multiple converters connected to form a compound converter, wherein each converter is a mode-evolution converter selected from a group including a polarization converter, a spatial converter, and combination thereof, wherein the polarization converter at least converts a mode of a polarization of at least one component of the optical signal, and the spatial mode converter at least converts a spatial mode order of at least one component of the optical signal.

06-20-2013

20130272644

Multi-Mode Interference Manipulator - A multi-mode interference includes a core portion suitable, at any point, for propagating an optical signal having multiple spatial modes. The core portion includes a shifting section for shifting phases of the spatial modes of the optical signal.

10-17-2013

Patent applications by Bingnan Wang, Boston, MA US

Chang-Ning J. Wang, Andover, MA US

Patent application number

Description

Published

20090118484

FORMATION OF NOVEL NUCLEIC ACID COMPLEXES AND DETECTION THEREOF - This invention relates to a process and system to amplify and detect recombinational non-reciprocal cross-over reactions between homologous nucleic acid molecules without the assistance from a protein factor. The result of a chain reaction of non-reciprocal cross-overs is stoichiometrical formation of nucleic acid conglomerate complex that binds significantly more ethidium bromide or other fluorophores than a canonical B-form double helical nucleic acid does, emitting much stronger fluorescence. Such nucleic acid conglomerate complex can be easily detected by conventional methods, therefore can be used to detect any target molecule of interest.

05-07-2009

Chih-Hao Wang, Brimfield, MA US

Patent application number

Description

Published

20110262090

SINGLE-POLARIZATION FIBER - Embodiments of the invention relate to a single-polarization fiber that may include a W-type refractive-index profile having a depressed region along an unguided principal axis of the fiber, and a quasi step-index profile along a guided principal axis of the fiber. The quasi step-index profile may have a depressed region with a radial extent at least twice that of the depressed region along the unguided axis.

10-27-2011

20130287338

Optical Couplers And Methods For Making Same - The present invention relates generally to optical waveguides for the transmission of electromagnetic energy. The present invention relates more particularly to optical couplers for coupling optical fibers, and methods for making them. One aspect of the present invention is an optical coupler for use with a polarization-maintaining input optical fiber and a polarization-maintaining output optical fiber. The coupler includes: a tube having a wide end, a narrow end having an end face, and a taper therebetween; a polarization-maintaining feed-through optical fiber having a first end having an end face and a second end, the polarization-maintaining feed-through optical fiber being disposed within the tube from the wide end to the narrow end, at least the narrow end of the tube being fused around a first length of the polarization-maintaining feed-through optical fiber including the first end of the polarization-maintaining feed-through optical fiber to form a coupler end face comprising the end face of the tube and the end face of the first end of the polarization-maintaining feed-through optical fiber. In one aspect of the invention, the polarization-maintaining feed-through optical fiber has an outer diameter no greater than about 200 μm in the region in which the tube is fused around it. In another aspect of the invention, the polarization-maintaining feed-through optical fiber has an outer diameter at the coupler end face no greater than about 75% of the diameter of the polarization-maintaining input optical fiber.

10-31-2013

Clarence J. Wang, Arlington, MA US

Patent application number

Description

Published

20100062002

Brain Endothelial Cell Expression Patterns - To gain a better understanding of brain tumor angiogenesis, new techniques for isolating brain endothelial cells (ECs) and evaluating gene expression patterns were developed. When transcripts from brain ECS derived from normal and malignant colorectal tissues were compared with transcripts from non-endothelial cells, genes predominantly expressed in the endothelium were identified. Comparison between normal- and tumor-derived endothelium revealed genes that were specifically elevated in tumor-associated brain endothelium. These results confirm that neoplastic and normal endothelium in human brains are distinct at the molecular level, and have significant implications for the development of anti-angiogenic therapies in the future.

03-11-2010

Daniel Wang, Duxbury, MA US

Patent application number

Description

Published

20100152099

MACROCYCLIC COMPOUNDS FOR INHIBITION OF TUMOR NECROSIS FACTOR ALPHA - The invention provides macrocyclic compounds and methods for their synthesis and use. In particular, the invention provides macrocyclic compounds that modulate the activity of tumor necrosis factor alpha and/or are useful in the treatment of medical conditions, such as, rheumatoid arthritis, psoriasis, and asthma.

06-17-2010

Dezhi Wang, Wellesley, MA US

Patent application number

Description

Published

20080202575

METHODS FOR HIGH FIGURE-OF-MERIT IN NANOSTRUCTURED THERMOELECTRIC MATERIALS - Thermoelectric materials with high figures of merit, ZT values, are disclosed. In many instances, such materials include nano-sized domains (e.g., nanocrystalline), which are hypothesized to help increase the ZT value of the material (e.g., by increasing phonon scattering due to interfaces at grain boundaries or grain/inclusion boundaries). The ZT value of such materials can be greater than about 1, 1.2, 1.4, 1.5, 1.8, 2 and even higher. Such materials can be manufactured from a thermoelectric starting material by generating nanoparticles therefrom, or mechanically alloyed nanoparticles from elements which can be subsequently consolidated (e.g., via direct current induced hot press) into a new bulk material. Non-limiting examples of starting materials include bismuth, lead, and/or silicon-based materials, which can be alloyed, elemental, and/or doped. Various compositions and methods relating to aspects of nanostructured thermoelectric materials (e.g., modulation doping) are further disclosed.

08-28-2008

20090200912

Methods for Growing Carbon Nanotubes on Single Crystal Substrates - Methods for growing carbon nanotubes on single crystal substrates are disclosed. A method of producing a nanostructure material comprises coating a single crystal substrate with a catalyst film to form a catalyst coated substrate; annealing the catalyst film by supplying a first promoter gas to the catalyst coated substrate at a first temperature and a first pressure; and supplying a second promoter gas and a carbon-source gas to the catalyst coated substrate in a substantially water-free atmosphere at a second pressure and a second temperature for a time period to cause growth of nanostructures on the catalyst coated substrate. The nanostructure material is used in various applications.

08-13-2009

20150068574

METHODS FOR HIGH FIGURE-OF-MERIT IN NANOSTRUCTURED THERMOELECTRIC MATERIALS - Thermoelectric materials with high figures of merit, ZT values, are disclosed. In many instances, such materials include nano-sized domains (e.g., nanocrystalline), which are hypothesized to help increase the ZT value of the material (e.g., by increasing phonon scattering due to interfaces at grain boundaries or grain/inclusion boundaries). The ZT value of such materials can be greater than about 1, 1.2, 1.4, 1.5, 1.8, 2 and even higher. Such materials can be manufactured from a thermoelectric starting material by generating nanoparticles therefrom, or mechanically alloyed nanoparticles from elements which can be subsequently consolidated (e.g., via direct current induced hot press) into a new bulk material. Non-limiting examples of starting materials include bismuth, lead, and/or silicon-based materials, which can be alloyed, elemental, and/or doped. Various compositions and methods relating to aspects of nanostructured theromoelectric materials (e.g., modulation doping) are further disclosed.

03-12-2015

Patent applications by Dezhi Wang, Wellesley, MA US

Di Wang, Worcester, MA US

Patent application number

Description

Published

20110246223

ACTIVE COMPLEX EVENT PROCESSING OR INFECTION CONTROL AND HYGIENE MONITORING - An apparatus, system and method for processing a stream of events in accordance with a set of queries that apply complex event pattern matching, and for performance of actions in accordance with active rules associated with those queries. The execution of actions can take the form of system state changes that in turn can affect the outcome of other queries. Scheduling policies assure both correct and high-performance execution of concurrent event pattern queries and active rules. The stream of events can be associated with a variety of applications including monitoring of hygiene and infection control activities associated with health care.

10-06-2011

20120166417

ASYNCHRONOUS TRANSFER OF STATE INFORMATION BETWEEN CONTINUOUS QUERY PLANS - Described herein are technologies pertaining to migrating state information of operators in a first continuous query plan to a second continuous query plan in an asynchronous manner, such that the first continuous query plan need not cease executing during the migrating of the state information. State information pertaining to stateful operators, such as join operators, is migrated from the first continuous query plan to the second continuous query plan by way of a transformation plan. State matching is utilized to generate the transformation plan.

06-28-2012

Dunwei Wang, Boston, MA US

Patent application number

Description

Published

20090117741

METHOD FOR FABRICATING MONOLITHIC TWO-DIMENSIONAL NANOSTRUCTURES - A patterning method for the creation of two-dimensional nanowire structures. Nanowire patterning methods are used with lithographical patterning approaches to form patterns in a layer of epoxy and resist material. These patterns are then transferred to an underlying thin film to produce a two-dimensional structure with desired characteristics.

05-07-2009

Dunwei Wang, Newton Highlands, MA US

Patent application number

Description

Published

20100043877

Hetero-Nanostructures for Solar Energy Conversions and Methods of Fabricating Same - The embodiments disclosed herein relate to hetero-nanostructures for efficient solar energy conversions, and more particularly to the fabrication of titanium dioxide hetero-nanostructures and methods of using same for water splitting. In an embodiment, a hetero-nanostructure includes a plurality of connected and spaced-apart nanobeams linked together at an about 90-degree angle, the plurality of nanobeams including a conductive silicide core having an n-type photoactive titanium dioxide shell. In an embodiment, a device for splitting water to generate hydrogen and oxygen includes a first compartment two-dimensional hetero-nanostructure having a plurality of connected and spaced-apart nanobeams, each nanobeam substantially perpendicular to another nanobeam, the plurality of nanobeams including an n-type photoactive titanium dioxide shell having a highly conductive core; and a second compartment copper-doped titanium dioxide nanostructure, wherein the first compartment and the second compartment are separated by a semi-permeable membrane.

02-25-2010

20100044072

Methods of Fabricating Complex Two-Dimensional Conductive Silicides - The embodiments disclosed herein relate to the fabrication of complex two-dimensional conductive silicide nanostructures, and methods of fabricating the nanostructures. In an embodiment, a conductive silicide includes a plurality of connected and spaced-apart nanobeams linked together at an about 90-degree angle, the plurality of nanobeams forming a two-dimensional nanostructure having a mesh-like appearance. In an embodiment, a method of fabricating a two-dimensional conductive silicide includes performing chemical vapor deposition, wherein one or more gas or liquid precursor materials carried by a carrier gas stream react to form a nanostructure having a mesh-like appearance and including a plurality of connected and spaced-apart nanobeams linked together at an about 90-degree angle.

Dual Absorber Electrodes - Dual absorber electrodes are disclosed. In some embodiments, a dual absorber electrode includes a first absorber material, such as silicon, having a first bandgap, and a second absorber material, such as hematite, deposited on a surface of the first absorber material, the second absorber material having a second bandgap larger than the first bandgap of the first absorber. In some embodiments, the dual absorber electrodes of the present embodiment may be utilized in an electrolytic cell for water splitting.

Fengjiang Wang, Northborough, MA US

Patent application number

Description

Published

20090005456

PHENYL SUBSTITUTED CYCLOALKYLAMINES AS MONOAMINE REUPTAKE INHIBITORS - Phenyl-substituted cyclohexylamine derivatives and method for their synthesis and characterization are disclosed. Use of these compounds to treat/prevent neurological disorders as well as methods for their synthesis are set forth herein. Exemplary compounds of the invention inhibit reuptake of endogenous monoamines, such as dopamine, serotonin and norepinephrine (e.g., from the synaptic cleft) and modulate one or more monoamine transporter. Pharmaceutical formulations incorporating compounds of the invention are also provided.

01-01-2009

20090163593

AMINES THAT INHIBIT A MAMMALIAN ANANDAMIDE TRANSPORTER, AND METHODS OF USE THEREOF - One aspect of the present invention relates to amines. A second aspect of the present invention relates to the use of the amines as inhibitors of a mammalian anandamide transporter. The compounds of the present invention will also find use in the treatment of numerous ailments, conditions and diseases which afflict mammals, including but not limited to asthma, neuropathic pain, persistent pain, inflammatory pain, hyperactivity, hypertension, brain ischemia, Parkinson's disease, spasticity, Tourette's syndrome, schizophrenia, hemorrhagic shock, septic shock, cardiac shock, migrane, Horton's headache, multiple sclerosis, anorexia, AIDS wasting syndrome, organ rejection, autoimmune diseases, allergy, arthritis, Crohn's disease, malignant gliomas, neurodegenerative diseases, Huntington's chorea, glaucoma, nausea, anxiety, psychosis, attention deficit hyperactivity disorder, premature ejaculation, and stroke. Another aspect of the present invention relates to combinatorial libraries of amines, and methods for preparing the libraries.

06-25-2009

20090258901

LIGANDS FOR MONOAMINE RECEPTORS AND TRANSPORTERS, AND METHODS OF USE THEREOF - One aspect of the present invention relates to heterocyclic compounds. A second aspect of the present invention relates to the use of the heterocyclic compounds as ligands for various mammalian cellular receptors, including dopamine, serotonin, or norepinephrine transporters. The compounds of the present invention will find use in the treatment of numerous ailments, conditions and diseases which afflict mammals, including but not limited to addiction, anxiety, depression, sexual dysfunction, hypertension, migraine, Alzheimer's disease, obesity, emesis, psychosis, schizophrenia, Parkinson's disease, inflammatory pain, neuropathic pain, Lesche-Nyhane disease, Wilson's disease, and Tourette's syndrome. An additional aspect of the present invention relates to the synthesis of combinatorial libraries of the heterocyclic compounds, and the screening of those libraries for biological activity, e.g., in assays based on dopamine transporters.

10-15-2009

20100190861

CYCLOALKYLAMINES AS MONOAMINE REUPTAKE INHIBITORS - The invention relates to novel cyclohexylamine derivatives and their use in the treatment and/or prevention of central nervous system (CNS) disorders, such as depression, anxiety, schizophrenia and sleep disorder as well as methods for their synthesis. The invention also relates to pharmaceutical compositions containing the compounds of the invention, as well as methods of inhibiting reuptake of endogenous monoamines, such as dopamine, serotonin and norepinephrine from the synaptic cleft and methods of modulating one or more monoamine transporter.

07-29-2010

20110313013

TRIPLE REUPTAKE INHIBITORS AND METHODS OF THEIR USE - Provided herein are bicyclic compounds and methods of synthesis thereof. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders. Compounds provided herein inhibit uptake of endogenous monoamines, such as dopamine, serotonin and norepinephrine (e.g., from the synaptic cleft) and modulate one or more monoamine transporter. Pharmaceutical formulations containing the compounds are also provided.

12-22-2011

20140107175

TRIPLE REUPTAKE INHIBITORS AND METHODS OF THEIR USE - Provided herein are bicyclic compounds and methods of synthesis thereof. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders. Compounds provided herein inhibit re-uptake of endogenous monoamines, such as dopamine, serotonin and norepinephrine (e.g., from the synaptic cleft) and modulate one or more monoamine transporter. Pharmaceutical formulations containing the compounds are also provided.

04-17-2014

20140121282

PHENYL SUBSTITUTED CYCLOALKYLAMINES AS MONOAMINE REUPTAKE INHIBITORS - Phenyl-substituted cyclohexylamine derivatives and method for their synthesis and characterization are disclosed. Use of these compounds to treat/prevent neurological disorders as well as methods for their synthesis are set forth herein. Exemplary compounds of the invention inhibit reuptake of endogenous monoamines, such as dopamine, serotonin and norepinephrine (e.g., from the synaptic cleft) and modulate one or more monoamine transporter. Pharmaceutical formulations incorporating compounds of the invention are also provided.

05-01-2014

Patent applications by Fengjiang Wang, Northborough, MA US

Fugui Wang, Sterling, MA US

Patent application number

Description

Published

20090156218

HANDING OFF ACTIVE CONNECTIONS - A connection is established between an access terminal and a first radio network controller through a first radio node. The first radio node is controllable primarily by the first radio network controller. The connection is maintained with the first radio network controller as the access terminal moves from a coverage area of the first radio node toward a coverage area of a second radio node. The second radio node is controllable primarily by a second radio network controller and controllable subordinately by the first radio network controller. A connection is also established through the second radio node. Upon a fulfillment of a predetermined criterion, the connection is transferred from the first radio network controller to the second radio network controller.

06-18-2009

20090300336

Microprocessor with highly configurable pipeline and executional unit internal hierarchal structures, optimizable for different types of computational functions - The invention resides in a flexible data pipeline structure for accommodating software computational instructions for varying application programs and having a programmable embedded processor with internal pipeline stages the order and length of which varies as fast as every clock cycle based on the instruction sequence in an application program preloaded into the processor, and wherein the processor includes a data switch matrix selectively and flexibly interconnecting pluralities of mathematical execution units and memory units in response to said instructions, and wherein the execution units are configurable to perform operations at different precisions of multi-bit arithmetic and logic operations and in a multi-level hierarchical architecture structure.

12-03-2009

20090300337

Instruction set design, control and communication in programmable microprocessor cases and the like - Improved instruction set and core design, control and communication for programmable microprocessors is disclosed, involving the strategy for replacing centralized program sequencing in present-day and prior art processors with a novel distributed program sequencing wherein each functional unit has its own instruction fetch and decode block, and each functional unit has its own local memory for program storage; and wherein computational hardware execution units and memory units are flexibly pipelined as programmable embedded processors with reconfigurable pipeline stages of different order in response to varying application instruction sequences that establish different configurations and switching interconnections of the hardware units.

Gregory Wang, Brighton, MA US

Patent application number

Description

Published

20090235172

METHOD, APPARATUS, AND COMPUTER PROGRAM FOR PROVIDING WEB SERVICE TESTING - A method, apparatus, and a computer program product for providing web service testing are provided. The apparatus may include a processor that is configured to provide a user interface for a testing tool accessible in a distributed network architecture. The processor may also be configured to receive selections of an application(s) to be tested that is accessible in a distributed network architecture, a function(s) that is associated with the selected application and a method(s) that is associated with the selected function(s). Additionally, the processor may be configured to receive selections of a test case(s) that is associated with the selected method(s). Moreover, the processor may be configured to automatically conduct the selected test case(s).

09-17-2009

Guan Wang, Worcester, MA US

Patent application number

Description

Published

20110220915

Off-Axis Silicon Carbide Substrates - A method of epitaxial growth of a material on a crystalline substrate includes selecting a substrate having a crystal plane that includes a plurality of terraces with step risers that join adjacent terraces. Each terrace of the plurality or terraces presents a lattice constant that substantially matches a lattice constant of the material, and each step riser presents a step height and offset that is consistent with portions of the material nucleating on adjacent terraces being in substantial crystalline match at the step riser. The method also includes preparing a substrate by exposing the crystal plane; and epitaxially growing the material on the substrate such that the portions of the material nucleating on adjacent terraces merge into a single crystal lattice without defects at the step risers.

09-15-2011

20120167477

ABRASIVE PARTICLE AND METHOD OF FORMING SAME - An abrasive article comprising an abrasive particle including a core comprising a compressible material, an intermediate layer comprising a binder material overlying an exterior surface of the core, and an outer layer comprising abrasive grains overlying the intermediate layer.

07-05-2012

20130000210

ABRASIVE SEGMENT COMPRISING ABRASIVE AGGREGATES INCLUDING SILICON CARBIDE PARTICLES - An abrasive article can include an abrasive segment. The abrasive segment can have a body that includes a plurality of abrasive aggregates. In addition, the abrasive aggregates can include a plurality of silicon carbide particles bonded together by a binder material phase. The abrasive aggregates can be contained within a bond material that includes a magnesia-based cement. In an embodiment, the binder material phase can include a vitreous phase material and a crystalline phase material. In particular instances, the binder material phase can include a certain porosity. In another embodiment, the abrasive segment can be formed from a mixture of abrasive aggregates including silicon carbide and a magnesia-based bond material.

01-03-2013

20130000212

LIQUID PHASE SINTERED SILICON CARBIDE ABRASIVE PARTICLES - An abrasive article includes a bonded abrasive body having abrasive particles contained within a bond material. The abrasive particles include silicon carbide and are essentially free of carbon-based and boron-based sintering aid materials. In an embodiment, the bond material can include a phenolic resin. In another embodiment, the bonded abrasive body can include an oxide phase disposed interstitially between the silicon carbide abrasive particles. In an additional embodiment, the abrasive particles can consist essentially of silicon carbide and aluminum oxide in a ratio of silicon carbide to alumina of at least about 8:1.

01-03-2013

20130000215

ABRASIVE AGGREGATE INCLUDING SILICON CARBIDE AND A METHOD OF MAKING SAME - An abrasive article can include an abrasive aggregate with the abrasive aggregate having a plurality of silicon carbide particles bonded together by a binder material. The binder material can include a vitreous phase material, a crystalline phase material, or both. In an embodiment, the crystalline phase material can include an aluminosilicate material. In a particular embodiment, abrasive aggregates can be formed from a mixture including silicon carbide particles, a binder material, and a liquid carrier. The mixture can be formed into a number of green granules that are vibrated and heated on a platen. In an illustrative embodiment, the green granules can then be heated to form abrasive aggregates.

01-03-2013

20130000216

ABRASIVE ARTICLES INCLUDING ABRASIVE PARTICLES OF SILICON NITRIDE - An abrasive article includes a body having abrasive particles contained within a bond material. The abrasive particles can include a majority content of silicon nitride and a minority content of sintering material including at least two rare-earth oxide materials. In an embodiment, the rare-earth oxide materials can include Nd

LIQUID PHASE SINTERED SILICON CARBIDE ABRASIVE PARTICLES - An abrasive article includes a bonded abrasive body having abrasive particles contained within a bond material. The abrasive particles include silicon carbide and are essentially free of carbon-based and boron-based sintering aid materials. In an embodiment, the bond material can include a phenolic resin. In another embodiment, the bonded abrasive body can include an oxide phase disposed interstitially between the silicon carbide abrasive particles. In an additional embodiment, the abrasive particles can consist essentially of silicon carbide and aluminum oxide in a ratio of silicon carbide to alumina of at least about 8:1.

Hong-Xing Wang, Boston, MA US

Patent application number

Description

Published

20110076694

METHOD OF ASSESSING MAMMALIAN EMBRYO QUALITY - A method of assessing the health of each oocyte or embryo of a mammal from a plurality of oocytes/embryos of the mammal is provided. The method comprises the steps of: measuring gap junctional coupling strength or connexin43 expression of follicular cells associated with each oocyte; and identifying the gap junctional coupling strength/connexin43 expression of follicular cells associated with each oocyte, wherein the greater the coupling strength/connexin43 expression of follicular cells associated with an oocyte relative to the coupling strength/connexin43 expression of follicular cells associated with each other oocyte, the healthier the oocyte and the embryo resulting from that oocyte. Kits for conducting these methods are also provided.

03-31-2011

Huashan Wang, Pittsfield, MA US

Patent application number

Description

Published

20090126778

LUMINESCENT SOLAR CONCENTRATORS - A luminescent solar concentrator comprises a primary waveguide and at least one photovoltaic cell. The primary waveguide has a curved surface which concentrates light on a perimeter. The photovoltaic cell is oriented at the perimeter so that it can both receive the concentrated light and receive direct light as well. A back sheet may be provided that provides structural support and protection. The perimeter may have the shape of a polygon where a photovoltaic cell is oriented along each edge. Modules and arrays of such units are also disclosed.

05-21-2009

Jianfei Wang, Cambridge, MA US

Patent application number

Description

Published

20110127547

CAVITY-ENHANCED MULTISPECTRAL PHOTONIC DEVICES - A multispectral pixel structure is provided that includes a plurality of stacked cavity arrangements for emitting or detecting a plurality of specified wavelengths, wherein each stacked cavity arrangement having a photoactive layer for spectral emission or detection of one of the specified wavelengths. The photoactive layer is positioned within a resonant cavity stack and the resonant cavity stack being positioned between two adjacent mirror stacks. A plurality of coupling-matching layers are positioned between one or more of the stack mirror arrangements for controlling optical phase and coupling strength between emitted or incident light and resonant modes in each of the stacked cavity arrangements.

06-02-2011

Jianna Wang, Grafton, MA US

Patent application number

Description

Published

20100265561

ELECTRO-OPTIC DISPLAYS, AND METHODS FOR DRIVING SAME - The invention relates to electro-optic displays and methods for driving such displays. The invention provides (i) electrochromic displays with solid charge transport layers; (ii) apparatus and methods for improving the contrast and reducing the cost of electrochromic displays; (iii) apparatus and methods for sealing electrochromic displays from the outside environment and preventing ingress of contaminants into such a display; and (iv) methods for adjusting the driving of electro-optic displays to allow for environmental and operating parameters.

10-21-2010

20120167477

ABRASIVE PARTICLE AND METHOD OF FORMING SAME - An abrasive article comprising an abrasive particle including a core comprising a compressible material, an intermediate layer comprising a binder material overlying an exterior surface of the core, and an outer layer comprising abrasive grains overlying the intermediate layer.

07-05-2012

20120192500

COATED ABRASIVE AGGREGATES AND PRODUCTS CONTAING SAME - A coated abrasive product includes a particulate material containing green, unfired abrasive aggregates having a generally spheroidal or toroidal shape, the aggregates formed from a composition comprising abrasive grit particles, a nanoparticle binder, a dual function material, and a cross-linking agent. These green unfired abrasive aggregates can also be used in free abrasive products and bonded abrasive products.

08-02-2012

20130014445

COATED ABRASIVE AGGREGATES AND PRODUCTS CONTAING SAME - Abrasive aggregates and fixed abrasive articles comprising formaldehyde-free polymer binder and a plurality of abrasive grains are provided that are particularly suitable for machining operations, in which abrasion is carried out to remove material and improve surface quality. Certain embodiments combine an abrasive grain, which can be in the form of microparticles, and a formaldehyde-free polymer binder, which can be in the form of a polymer resin and cross-linking agent. Optionally, the abrasive aggregate can contain a secondary cross-linking agent, or a functional filler, such as a grinding aid.

01-17-2013

20130095731

ABRASIVE PRODUCTS AND METHODS FOR FINISHING HARD SURFACES - A coated abrasive product includes green, unfired abrasive aggregates having a generally spheroidal or toroidal shape, the aggregates formed from a composition comprising abrasive grit particles and a nanoparticle binder, wherein the abrasive aggregates are dispersed within a polymer resin coating, and wherein the coated abrasive product is capable of superfinishing a metal surface having an initial Ra in the range of about 1.5 micro inches to about 12.5 micro inches prior to application of the coated abrasive product and after application the surface has an Ra of less than 1.0 micro inch.

04-18-2013

20130189911

ABRASIVE PRODUCTS AND METHODS FOR FINISHING COATED SURFACES - A coated abrasive product includes green, unfired abrasive aggregates having a generally spheroidal or toroidal shape, the aggregates formed from a composition comprising abrasive grit particles, a nanoparticle binder, a sulfosuccinate, and a crosslinking, wherein the abrasive aggregates are dispersed within a polymer resin coating comprising a mixture of copolyester resin. The coated abrasive product is capable of finishing coated surfaces and repairing defects in coated surfaces, including surfaces coated with automotive primers, paints, clear coats, and combinations thereof.

07-25-2013

20130283702

ABRASIVE PRODUCTS AND METHODS FOR FINE POLISHING OF OPHTHALMIC LENSES - A coated abrasive product including green, unfired abrasive aggregates having a generally spheroidal or toroidal shape, the aggregates formed from a composition comprising abrasive grit particles and a nanoparticle binder, wherein the abrasive aggregates are dispersed within a polymer resin coating, and wherein the coated abrasive product is capable of polishing an optical component, including ophthalmic lenses without the need to apply an abrasive slurry.

10-31-2013

20130298471

ABRASIVE PRODUCTS AND METHODS FOR FINISHING SURFACES - An engineered coated abrasive product having a three dimensional pattern of abrasive structures formed by embossing an abrasive slurry formulation that was first surface coated with a functional powder, wherein the abrasive slurry includes green, unfired abrasive aggregates having a generally spheroidal or toroidal shape, the aggregates formed from a composition comprising abrasive grit particles and a nanoparticle binder. The coated abrasive product is capable of finishing and repairing defects in surfaces, including coated surfaces.

11-14-2013

Patent applications by Jianna Wang, Grafton, MA US

Jia-Yu Wang, Amherst, MA US

Patent application number

Description

Published

20080230514

METHOD OF PRODUCING NANOPATTERNED TEMPLATES - Nanopatterned substrates can be prepared by a method that includes forming a block copolymer film on a substrate, annealing the block copolymer film, surface reconstructing the annealed block copolymer film, coating an etch-resistant layer on the surface reconstructed block copolymer film, etching the resist-coated block copolymer film to create an etched article comprising a nanopatterned substrate, and separating the etch-resistant layer and the block copolymer film from the nanopatterned substrate. The method is applicable to a wide variety of substrate materials, avoids any requirement for complicated procedures to produce long-range order in the block copolymer film, and avoids any requirement for metal functionalization of the block copolymer.

09-25-2008

Jim Jianping Wang, Dover, MA US

Patent application number

Description

Published

20100150157

PEER TO MULTI-PEER ROUTING - A collaboration system using peer-to-multi-peer distribution of messages representing changes to a shared workspace. Each peer determines a distribution mechanism for messages to each of the target peers sharing the workspace. The selected distribution mechanism may depend on capabilities of a home relay associated with a peer initiating a message. Further, messages to subsets of the target peers sharing the workspace may be distributed using a session for each subset on which each message is sent only one time. The subset of target peers associated with some of the sessions may be selected so that target peers for which communication attempts have failed are grouped in the same session. In some scenarios, the initiating peer may provide multiple routing paths for target peers in a session and the home relay server may appropriately forward the message to the target peers, using one of the routing paths.

06-17-2010

Jimpo Wang, Tyngsboro, MA US

Patent application number

Description

Published

20090085419

Hybrid touchdown bearing system - Upon operation, flywheel assemblies sand other such rotational mechanisms are released by mechanical backup bearings, which then normally remain disengaged until shutdown as the flywheel assembly is levitated by the axial magnetic field. However, either due to over heating of bearings, power failure or other stimuli, flywheels often suffer a phenomenon deemed as touchdown down from the levitation state. During this touchdown event, flywheels inherently lose rotational momentum, thus ceasing to generate and release power and often cause damage to components as well as casing. Enhancements developed herein, through the introduction of the instant secondary hybrid touchdown bearing system, allow flywheels and other such systems to retain rotational momentum and continue generation of energy. Further, the instant system negates damage to system components, as well as bearing wear.

04-02-2009

Jimpo Wang, Westford, MA US

Patent application number

Description

Published

20100156219

Advanced Flywheel and Method - A flywheel levitation apparatus and associated method are described for use in a flywheel driven power storage system having a rotor and which provides for an upward vertical movement of the rotor along an axis of rotation. The rotor includes a rotor face defining a cutaway section. A magnetic lifting force is applied to the rotor to at least in part serve in levitating the rotor. The magnetic lifting force exhibits a modified gap sensitivity that is smaller as compared to a conventional gap sensitivity that would be exhibited in an absence of the cutaway section.

06-24-2010

20130043750

ADVANCED FLYWHEEL AND METHOD - A flywheel levitation apparatus and associated method are described for use in a flywheel driven power storage system having a rotor and which provides for an upward vertical movement of the rotor along an axis of rotation. The rotor includes a rotor face defining a cutaway section. A magnetic lifting force is applied to the rotor to at least in part serve in levitating the rotor. The magnetic lifting force exhibits a modified gap sensitivity that is smaller as compared to a conventional gap sensitivity that would be exhibited in an absence of the cutaway section.

02-21-2013

Jimpo Wang, Wilmington, MA US

Patent application number

Description

Published

20080315696

Lift magnet mechanism for flywheel power storage systems - Electric power is stored in a flywheel assembly, from a dc power buss, and supplied to the buss, through electronics associated with a motor/generator, its rotor integral with a flywheel supported by magnetic bearings. Upon operation, the flywheel assembly is released by mechanical backup bearings which then normally remain disengaged until shutdown as the flywheel assembly is levitated by the axial magnetic field. Enhancements developed herein smooth the flux density across discontinuities or segments present in permanent magnets due to presently limited capability for manufacture of large annular magnetic members. Herein, the introduction of a medium such as a steel cylindrical member to directly interface with the rotor as opposed to the segmented permanent magnet, greatly eradicates induced eddy current and heat on the rotor. In addition, exhibited is an annularly slotted rotor which allows for greater surface area for flux absorption.

Methods for prognosing the ability of a zearalenone analog compound to treat cancer - The instant invention provides methods of prognosing the ability of a zearalenone analog compound to treat a cancer in a subject, methods of prognosing the ability of a zearalenone analog compound to inhibit the growth of a cancer in a subject, and methods of prognosing the ability of a zearalenone analog compound to promote the activation of apoptosis of a cancer in a subject. Methods of treating a cancer in a subject are also provided. The invention also pertains to methods of determining whether a cancer in a subject is sensitive to treatment with a zearalenone analog compound.

07-02-2009

20110144101

MACROCYCLIC COMPOUNDS USEFUL AS PHARMACEUTICALS - The present invention provides methods for the use of compounds having formula (I) in the treatment of various disorders including inflammatory or autoimmune disorders, and disorders involving malignancy or increased angiogenesis, wherein R

06-16-2011

20130196987

MACROCYCLIC COMPOUNDS USEFUL AS PHARMACEUTICALS - The present invention provides compounds, methods for the synthesis thereof and methods for the use thereof in the treatment of various disorders including inflammatory or autoimmune disorders, and disorders involving malignancy or increased angiogenesis.

Joyce Jeanpin Wang, Watertown, MA US

Patent application number

Description

Published

20090006382

SYSTEM AND METHOD FOR MEASURING THE QUALITY OF DOCUMENT SETS - Systems and methods are described that calculate the interestingness of a set of one or more records in a database, either absolutely (i.e., compared to an overall collection of records) or relative to some other set of records. In one embodiment, the measure is a relative entropy value that has been normalized. Various applications of the measure are described in the context of an information retrieval system. These applications include, for example, guiding query interpretation, guiding view selection and summarization, intelligent ranges, event detection, concept triggers and interpreting user actions, hierarchy discovery, and adaptive data mining.

01-01-2009

20090006383

SYSTEM AND METHOD FOR MEASURING THE QUALITY OF DOCUMENT SETS - Systems and methods are described that calculate the interestingness of a set of one or more records in a database, either absolutely (i.e., compared to an overall collection of records) or relative to some other set of records. In one embodiment, the measure is a relative entropy value that has been normalized. Various applications of the measure are described in the context of an information retrieval system. These applications include, for example, guiding query interpretation, guiding view selection and summarization, intelligent ranges, event detection, concept triggers and interpreting user actions, hierarchy discovery, and adaptive data mining.

01-01-2009

20090006384

SYSTEM AND METHOD FOR MEASURING THE QUALITY OF DOCUMENT SETS - Systems and methods are described that calculate the interestingness of a set of one or more records in a database, either absolutely (i.e., compared to an overall collection of records) or relative to some other set of records. In one embodiment, the measure is a relative entropy value that has been normalized. Various applications of the measure are described in the context of an information retrieval system. These applications include, for example, guiding query interpretation, guiding view selection and summarization, intelligent ranges, event detection, concept triggers and interpreting user actions, hierarchy discovery, and adaptive data mining.

01-01-2009

20090006385

SYSTEM AND METHOD FOR MEASURING THE QUALITY OF DOCUMENT SETS - Systems and methods are described that calculate the interestingness of a set of one or more records in a database, either absolutely (i.e., compared to an overall collection of records) or relative to some other set of records. In one embodiment, the measure is a relative entropy value that has been normalized. Various applications of the measure are described in the context of an information retrieval system. These applications include, for example, guiding query interpretation, guiding view selection and summarization, intelligent ranges, event detection, concept triggers and interpreting user actions, hierarchy discovery, and adaptive data mining.

01-01-2009

20090006386

SYSTEM AND METHOD FOR MEASURING THE QUALITY OF DOCUMENT SETS - Systems and methods are described that calculate the interestingness of a set of one or more records in a database, either absolutely (i.e., compared to an overall collection of records) or relative to some other set of records. In one embodiment, the measure is a relative entropy value that has been normalized. Various applications of the measure are described in the context of an information retrieval system. These applications include, for example, guiding query interpretation, guiding view selection and summarization, intelligent ranges, event detection, concept triggers and interpreting user actions, hierarchy discovery, and adaptive data mining.

01-01-2009

20090006387

SYSTEM AND METHOD FOR MEASURING THE QUALITY OF DOCUMENT SETS - Systems and methods are described that calculate the interestingness of a set of one or more records in a database, either absolutely (i.e., compared to an overall collection of records) or relative to some other set of records. In one embodiment, the measure is a relative entropy value that has been normalized. Various applications of the measure are described in the context of an information retrieval system. These applications include, for example, guiding query interpretation, guiding view selection and summarization, intelligent ranges, event detection, concept triggers and interpreting user actions, hierarchy discovery, and adaptive data mining.

01-01-2009

20090006438

SYSTEM AND METHOD FOR MEASURING THE QUALITY OF DOCUMENT SETS - Systems and methods are described that calculate the interestingness of a set of one or more records in a database, either absolutely (i.e., compared to an overall collection of records) or relative to some other set of records. In one embodiment, the measure is a relative entropy value that has been normalized. Various applications of the measure are described in the context of an information retrieval system. These applications include, for example, guiding query interpretation, guiding view selection and summarization, intelligent ranges, event detection, concept triggers and interpreting user actions, hierarchy discovery, and adaptive data mining.

01-01-2009

20120124032

SYSTEM AND METHOD FOR CONCEPT VISUALIZATION - Systems and methods are described that calculate the interestingness of a set of one or more records in a database, either absolutely (i.e., compared to an overall collection of records) or relative to some other set of records. In one embodiment, the measure is a relative entropy value that has been normalized. Various applications of the measure are described in the context of an information retrieval system. These applications include, for example, guiding query interpretation, guiding view selection and summarization, intelligent ranges, event detection, concept triggers and interpreting user actions, hierarchy discovery, and adaptive data mining.

05-17-2012

20120197877

SYSTEM AND METHOD FOR MEASURING THE QUALITY OF DOCUMENT SETS - Systems and methods are described that calculate the interestingness of a set of one or more records in a database, either absolutely (i.e., compared to an overall collection of records) or relative to some other set of records. In one embodiment, the measure is a relative entropy value that has been normalized. Various applications of the measure are described in the context of an information retrieval system. These applications include, for example, guiding query interpretation, guiding view selection and summarization, intelligent ranges, event detection, concept triggers and interpreting user actions, hierarchy discovery, and adaptive data mining.

08-02-2012

Julia Ying Wang, Brookline, MA US

Patent application number

Description

Published

20090317410

USE OF ZWITTERIONIC POLYSACCHARIDES FOR THE SPECIFIC MODULATION OF IMMUNE PROCESSES - The invention relates to three-dimensional molecular structure determination of polymers, three-dimensional computer molecular modeling, rational drug design, and immunomodulatory polymers. In particular the invention is directed to immunomodulatory polymers, as well as to methods for designing, selecting, and screening therapeutic agents having immunomodulatory activity.

12-24-2009

Kaiyu Wang, Peabody, MA US

Kenneth Kuan-Yuen Wang, Waltham, MA US

Patent application number

Description

Published

20100113474

Antineoplastic Combinations of 4-Anilino-3-Cyanoquinolines and Capecitabine - A combination of a 4-anilino-3-cyanoquinoline compound (e.g. HKI-272, SKI-606, EKB-569) and a capecitabine compound in the treatment of a neoplasm is provided. Regimens, kits, and methods for treatment of neoplasm, including breast cancer including metastatic breast cancer, and lung cancer, using this combination, optionally in combination with other anti-neoplastic agents, or immune modulators are also described.

05-06-2010

20140171384

ANTINEOPLASTIC COMBINATIONS OF 4-ANILINO-3-CYANOQUINOLINES AND CAPECITABINE - A combination of a 4-anilino-3-cyanoquinoline compound (e.g. HKI-272, SKI-606, EKB-569) and a capecitabine compound in the treatment of a neoplasm is provided. Regimens, kits, and methods for treatment of neoplasm, including breast cancer including metastatic breast cancer, and lung cancer, using this combination, optionally in combination with other anti-neoplastic agents, or immune modulators are also described.

Lu X. Wang, Northborough, MA US

Poguang Wang, Westborough, MA US

Patent application number

Description

Published

20090215185

Non-signal Imidazole Reagents for Mass Spectrometry Analysis of Phosphomonoesters - Analytical chemical reagents termed non-signal imidazoles and a method for their use that provide a host of advantages for analysis of phosphomonoesters are described. The method and compounds of the invention provide a host of advantages for the analysis of phosphomonoester-containing compounds, namely characteristic, multi-analyte detection with high sensitivity and specificity of known and unknown phosphomonoester-compounds simultaneously.

Non-Signal Imidazole Reagents for Mass Spectrometry Analysis of Phosphomonoesters - Analytical chemical reagents termed non-signal imidazoles and a method for their use that provide a host of advantages for analysis of phosphomonoesters are described. The method and compounds of the invention provide a host of advantages for the analysis of phosphomonoester-containing compounds, namely characteristic, multi-analyte detection with high sensitivity and specificity of known and unknown phosphomonoester-containing compounds simultaneously.

11-03-2011

20130313198

CAGED BAGS OF POROUS MATERIALS - Systems and methods employing beds of bagged and caged absorbent and adsorbent materials are disclosed. These inventions are useful in the area of solid phase extraction.

11-28-2013

Patent applications by Poguang Wang, Westborough, MA US

Qiuhong Wang, Tyngsboro, MA US

Patent application number

Description

Published

20090071989

Apparatus and methods for automatic shoe cover stripping - Protective shoe covers have been widely used in health care setting and some industry environment that require clean room condition. To strip off the disposed shoe covers in a hand-free and automated fashion is very desirable to the users, which provide physical convenience, time saving and economic merits. This disclosed invention provides methods and an automatic system for stripping of disposable shoe cover from user's foot/feet that includes the electromechanical complex, a micro control unit and its embedded software programs, control algorithm to guide the execution of the stripping functions in automated and hand-free fashion.

03-19-2009

Ruike R. Wang, Lexington, MA US

Patent application number

Description

Published

20080206632

BATTERY SEPARATOR - An alkaline battery includes a housing, a cathode disposed within the housing, an anode disposed within the housing, a separator disposed between the anode and the cathode, and an alkaline electrolyte contacting the anode and the cathode. The separator can include a tube having at an inner tube layer and an outer tube layer. The inner tube layer is disposed radially inward from the outer tube layer and no portion of the inner tube layer is disposed radially outward from any portion of the outer tube layer. The separator can also include a disc positioned at one end of the tube to create a closed end of the separator.

08-28-2008

Run-Ming Wang, Somerville, MA US

Patent application number

Description

Published

20080242658

Inhibitors of Iap - Novel compounds that inhibit the binding of the Smac protein to Inhibitor of Apoptosis Proteins (IAPs) of the formula I

Sha-Sha Wang, Wellesley, MA US

Patent application number

Description

Published

20110059455

METHODS AND COMPOSITIONS FOR DIRECT CHEMICAL LYSIS - A direct chemical lysis composition includes an assay compatible buffer composition and an assay compatible surfactant. When combined with a specimen storage composition, such compositions prevent undesired modifications to nucleic acid and proteins lysed from cells in the biological sample. Assays of samples from such compositions do not require expensive and time-consuming steps such as centrifugation and prolonged high temperature processing. The direct chemical lysis composition of the present invention permits direct nucleic acid extraction from the cells in the biological sample without the need to decant off the transport media or otherwise exchange the transport media with assay compatible buffers. There is no need to combine the sample with proteinase K or another enzyme to extract nucleic acids from the cells. A method for lysing cells to obtain target nucleic acid for assay and a kit for combining the direct chemical lysis composition with a sample are also contemplated.

03-10-2011

20110244457

IMMUNO-AMPLIFICATION - A high-sensitivity, low-background immuno-amplification assay is provided, which offers a streamlined workflow suitable for high-throughput assays of clinically relevant samples, such as blood and other bodily fluids. The assay comprises the use of two proximity members that each comprise an analyte-specific binding component conjugated to an oligonucleotide. Binding an analyte brings the oligonucleotide moieties of the proximity members in sufficiently close contact that the oligonucleotides form an amplicon. The presence of the analyte then is detected through amplification of the amplicon and detection of the amplified nucleic acids. The sensitivity of the assay of the present invention is improved by preventing spurious or non-specific amplicon formation by proximity members that are not complexed with an analyte.

10-06-2011

Shiquan Wang, Northborough, MA US

Patent application number

Description

Published

20100121511

LI-ION BATTERY ARRAY FOR VEHICLE AND OTHER LARGE CAPACITY APPLICATIONS - A large battery array, particularly for use in an electric vehicle, is formed of multiple modules, each containing plural battery cells and module management electronics. Each battery module has a nominal output voltage in the range of about 5 volts to about 17 volts. A controller communicates with individual battery modules in the array and controls switching to connect the modules in drive and charging configurations. The module management electronics monitor conditions of each battery module, including the cells it contains, and communicates these conditions to the controller. The module management electronics may place the modules in protective modes based upon the performance of each module in comparison to known or configurable specifications. The modules may be pluggable devices so that each module may be replaced if the module is in a permanent shutdown protective mode or if a non-optimal serviceable fault is detected.

Weidong Wang, Lexington, MA US

Patent application number

Description

Published

20090086727

Intelligent Routing in a Hybrid Peer-to-Peer System - Intelligent routing may be provided. First, a second peer via home relay may receive presence information indicating that a first peer is connected to a first foreign relay. Then the second peer may update, in response to the presence information, a routing table to indicate that a primary place to send data to the first peer is the first foreign relay. Next, the second peer may determine from the routing table that the primary place to send the data to the first peer is the first foreign relay. Next, the home relay may receive a request from a second peer to send data to the first peer via the first foreign relay. Then, in response to determining from the routing table that the primary place to send the data to the first peer is the first foreign relay, the data may be sent to the first foreign relay.

04-02-2009

Weisong Wang, Westford, MA US

Patent application number

Description

Published

20090016404

INTELLIGENT THERMOMETER - A device for measuring the body temperature of a user is provided. The device comprises a casing having an opening; a sensing device extending from the opening of the casing, the sensing device configured for measuring the body temperature of the user and generating an output signal when the sensing device is received by the user, the output signal indicative of the body temperature of the user; and a controller in electrical communication with the sensing device, the controller configured to receive the output signal and to calculate a temperature reading representative of the body temperature of the user, the controller further configured to determine whether the temperature reading is within one of a plurality of temperature ranges based on the age of the user, and the controller further configured to generate a dosage amount of a plurality of medicines based on the age of the user and weight of the user.

01-15-2009

20090150496

AUTOMATED TRANSLATOR FOR SYSTEM-GENERATED PREFIXES - A method is provided for localizing a prefix in a subject header field of an incoming electronic message. The method comprises receiving a value string of a subject header in an electronic message; identifying a system-generated prefix in the value string by parsing the value string and accessing a database storing a plurality of system-generated prefixes and a corresponding comparable local prefix for each of the plurality of system-generated prefixes; and converting the system-generated prefix to its corresponding comparable local prefix in the database.

06-11-2009

Wender Wang, Wilmington, MA US

Patent application number

Description

Published

20090294553

COMBINATION LIGHT AND A DEVICE FOR DISPENSING A VOLATILE SUBSTANCE - A combination lantern and insect repellent dispensing apparatus. Light is produced by light bulbs or LEDs whereas insect repellent is dispensed by heating a volatilizable insecticide The insecticide and portable light may be used either concurrently or independently of each other.

12-03-2009

20100276416

HEATING DEVICE HAVING ELECTRIC AND FUEL POWERED HEAT SOURCES - A portable device which generates heat and which can be used alternatively as a corded, plug-in device or as a cordless, fuel-powered device. The device has dual heating capabilities—each of which is powered by a unique cartridge. For use as a plug-in device an electric cartridge that connects the device to an adapter is utilized, whereas for use as a portable device a fuel cartridge is utilized for supplying a hydrocarbon fuel to support combustion. Use of one of the cartridges prevents the use of the other.

11-04-2010

20110057051

Combination Flashlight and a Device for Dispensing a Volatile Substance - A combination flashlight and insect repellent dispensing apparatus. Light is produced by light bulbs or LEDs whereas insect repellent is dispensed by heating a volatilizable insecticide. The insecticide and portable light may be used either concurrently or independently of each other.

03-10-2011

Patent applications by Wender Wang, Wilmington, MA US

Wenqin Wang, Somerville, MA US

Patent application number

Description

Published

20110002530

SUB-DIFFRACTION LIMIT IMAGE RESOLUTION IN THREE DIMENSIONS - The present invention generally relates to sub-diffraction limit image resolution and other imaging techniques, including imaging in three dimensions. In one aspect, the invention is directed to determining and/or imaging light from two or more entities separated by a distance less than the diffraction limit of the incident light. For example, the entities may be separated by a distance of less than about 1000 nm, or less than about 300 nm for visible light. In some cases, the position of the entities can be determined in all three spatial dimensions (i.e., in the x, y, and z directions), and in certain cases, the positions in all three dimensions can be determined to an accuracy of less than about 1000 nm. In one set of embodiments, the entities may be selectively activatable, i.e., one entity can be activated to produce light, without activating other entities. A first entity may be activated and determined (e.g., by determining light emitted by the entity), then a second entity may be activated and determined. The emitted light may be used to determine the x and y positions of the first and second entities, for example, by determining the positions of the images of these entities, and in some cases, with sub-diffraction limit resolution. In some cases, the z positions may be determined using one of a variety of techniques that uses intensity information or focal information (e.g., a lack of focus) to determine the z position. Non-limiting examples of such techniques include astigmatism imaging, off-focus imaging, or multi-focal-plane imaging.

01-06-2011

Xianghong S. Wang, Westford, MA US

Patent application number

Description

Published

20110166915

SYSTEM AND METHOD FOR DETERMINING A CUSTOMER CONTACT STRATEGY - A system and method determines a customer contact strategy that creates associations between customer characteristics and customer responsiveness to direct email campaigns. A plurality of variables relating to historical customer purchasing behavior, and customer responsiveness to direct mail campaigns, are evaluated. In addition, customer responsiveness to direct email campaigns are also evaluated, while also enabling the evaluation of a customer based on customer characteristics and responsiveness. Conventional direct mail campaigns utilize various models to identify customer propensity and prospective customer propensity. The present invention adds to these models a model to determine how well a customer responds to direct email campaigns, and then determines which form of direct contact is preferred at a customer level (i.e., on a customer by customer basis).

07-07-2011

Xiaoying Wang, West Roxbury, MA US

Patent application number

Description

Published

20110129526

COMPOSITIONS AND METHODS FOR TREATING VASCULAR DISEASE - The use of tPA to treat hemorrhagic transformation, neurotoxicity has been limited to short treatment time windows because a high dose of tPA required to generate sufficient amounts of the enzyme plasmin for clot lysis. The present invention combines tPA with recombinant Annexin A2 resulting in thrombolysis without hemorrhagic transformation at delayed times after stroke. This embodiment allows the administration of a lower, non-neurotoxic, tPA dose. Our results suggest this novel combination for stroke therapy may greatly improve both efficacy and safety, and prolong tPA therapeutic time window.

06-02-2011

Xihua Wang, Allston, MA US

Patent application number

Description

Published

20100039126

NANOCHANNEL-BASED SENSOR SYSTEM FOR USE IN DETECTING CHEMICAL OR BIOLOGICAL SPECIES - A sensor system for detecting a chemical or biological species includes a sensing element and a bias and measurement circuit. The sensing element includes nanochannels, each having an outer surface functionalized to chemically interact with the species to create a corresponding surface potential, and each having a sufficiently small cross section to exhibit a shift of a differential conductance characteristic into a negative bias operating region by a shift amount dependent on the surface potential. The bias and measurement circuit applies a bias voltage across two ends of the nanochannels sufficiently negative to achieve a desired dependence of the differential conductance on the surface potential, wherein the dependence has a steeply sloped region of high amplification substantially greater than a reference amplification at a zero-bias condition, thus achieving relatively high signal-to-noise ratio. The bias and measurement circuit converts the measured differential conductance into a signal indicative of presence or activity of the species of interest.

02-18-2010

20110021894

GLUCOSE SENSOR EMPLOYING SEMICONDUCTOR NANOELECTRONIC DEVICE - A glucose sensor employs a programmable glucose sensor array of a relatively large number of nanoelectronic devices (e.g. semiconductor field-effect devices) having control surfaces functionalized with a glucose-reactive substance and generating sensing signals indicative of sensed glucose level of a bodily fluid. The devices are divided into sub-sets sequentially enabled over successive intervals to achieve overall sensor lifetime many times longer than the lifetime of any single device in operation.

01-27-2011

20140030747

NANOCHANNEL-BASED SENSOR SYSTEM FOR USE IN DETECTING CHEMICAL OR BIOLOGICAL SPECIES - A sensor system for detecting a chemical or biological species includes a sensing element and a bias and measurement circuit. The sensing element includes nanochannels having an outer surface functionalized for interaction with the species to create a surface potential, and each having a sufficiently small cross section to exhibit a shift of differential conductance into a negative bias operating region by a shift amount dependent on the surface potential. The bias and measurement circuit applies a bias voltage across two ends of the nanochannels sufficiently negative to achieve a desired dependence of the differential conductance on the surface potential. The dependence has a steeply sloped region of high amplification substantially greater than a reference amplification at a zero-bias condition, thus achieving relatively high signal-to-noise ratio. The bias and measurement circuit converts the measured differential conductance into a signal indicative of presence or activity of the species.

01-30-2014

Patent applications by Xihua Wang, Allston, MA US

Xinwei Wang, Dunstable, MA US

Patent application number

Description

Published

20090238313

STEPPED GAIN MIXER - An amplified stepped gain mixer portion improves the signal-to-noise ratio of a receiver by using multiple gain states to improve linearity. The mixer portion includes an amplifier, a switch and two transistors. The amplifier output is coupled to the sources of the two transistors. An oscillating signal is present on the transistor gates. The transistor drains are coupled to one another through the switch when the switch is closed. The mixer portion operates in two modes. In a 1/2 mode, the mixer portion output current flows only through the first transistor and not through the second transistor because the switch is open. In a 2/2 mode, the mixer portion output current flows through both transistors. The mixer portion is configured such that the switch is closed when a switching signal is asserted. The switching signal is asserted when a bit of a mixer control register is written to.

09-24-2009

20130324062

POWER DETECTOR WITH TEMPERATURE COMPENSTATION - Power detectors with temperature compensation and having improved accuracy over temperature are disclosed. In an aspect of the disclosure, variations of a power detector gain over temperature is reduced by varying both the gate and drain voltages of MOS transistors within a power detector. In an exemplary design, an apparatus includes at least one MOS transistor, which receives an input signal, detects the power of the input signal based on a power detection gain, and provides an output signal indicative of the power of the input signal. The at least one MOS transistor is applied a variable gate bias voltage and a variable drain bias voltage in order to reduce variations of the power detection gain over temperature. At least one additional MOS transistor may receive a second variable gate bias voltage and provide the variable drain bias voltage for the at least one MOS transistor.

12-05-2013

20140266518

Step Attenuator with Constant Input Capacitance - A step attenuator with constant input capacitance and having good performance is disclosed. In an exemplary design, an apparatus includes a step attenuator having a constant input capacitance for different amounts of attenuation. The step attenuator receives an input signal, provides a variable amount of attenuation for the input signal, and provides an output signal. The step attenuator may include a plurality of attenuator sections coupled in series. Each attenuator section may include a plurality of capacitors and may have the constant input capacitance. At least one of the plurality of attenuator sections may be selected or unselected to obtain a selected amount of attenuation for the step attenuator. An attenuator section may provide a predetermined amount of attenuation or a variable amount of attenuation when selected. The apparatus may further include a power detector that receives and determines the power of the output signal from the step attenuator.

09-18-2014

20150022024

SWITCH LINEARIZER - Exemplary embodiments are related to switch linearizer. A device may include at least one switch. The device may further include a linearizer coupled to the at least one switch and configured to cancel at least a portion of distortion generated by the at least one switch in an off-state.

01-22-2015

20150035550

HIGH ACCURACY MEASUREMENT OF ON-CHIP COMPONENT PARAMETERS - Techniques for measuring on-chip component parameters are described herein. In one embodiment, a method for measuring one or more on-chip component parameters comprises measuring a time for an on-chip capacitor to charge to a voltage approximately equal to a reference voltage, and measuring a time for the on-chip capacitor to charge to a voltage approximately equal to a voltage across an on-chip component. The method also comprises determining a parameter of the on-chip component based on the measured time for the on-chip capacitor to charge to the voltage approximately equal to the reference voltage, the measured time for the on-chip capacitor to charge to the voltage approximately equal to the voltage across the on-chip component, and the reference voltage.

02-05-2015

20150042399

ANALOG SWITCH FOR RF FRONT END - Techniques for improving the linearity of radio-frequency (RF) front-end switches. In an aspect, open-loop techniques are disclosed for superimposing the output voltage of one or more negative rectifiers on a negative substrate bias voltage to reduce the non-linearities associated with voltage-dependent substrate leakage current. In another aspect, closed-loop techniques are further disclosed for maintaining the substrate bias voltage close to a reference voltage. Exemplary embodiments of the circuit blocks are further described.

02-12-2015

20150042412

DIRECTIONAL COUPLER CIRCUIT TECHNIQUES - Techniques for efficiently integrating directional coupler circuitry with other circuit elements of an RF front end. In an aspect, one or more inductors of an RF front end filter is incorporated into a first inductor of the directional coupler, and a capacitor is further coupled in parallel with the first inductor. In another aspect, circuitry associated with matching components of the RF front end may further be incorporated into the directional coupler design. Further techniques are provided for coupling directivity tuning elements to a second inductor of the directional coupler to improve the linearity of the coupler over other tuning techniques.

02-12-2015

Patent applications by Xinwei Wang, Dunstable, MA US

Xinwen Wang, Bedford, MA US

Patent application number

Description

Published

20100331213

MICROPARTICLES WITH ENHANCED COVALENT BINDING CAPACITY AND THEIR USES - A polyelectrolyte having multiple exposed functional groups, each such group being capable of covalently bonding to a molecule, is immobilized on a surface for the purpose of bonding to a biomolecule. The biomolecule can be, for example, a nucleic acid, e.g., an amine functionalized oligonucleotide. The polyelectrolyte can include, e.g., BSA (Bovine Serum Albumin) which is bound to a functionalized surface using a covalent immobilization strategy, e.g., reaction with the surface of a tosyl-activated microparticle. Following such reaction, exposed reactive functional groups on the protein, such as amine, carboxyl, thiol, hydroxyl groups can further be utilized to covalently couple the oligonucleotide of interest using suitable chemistry.

Xuerui Wang, Amherst, MA US

Patent application number

Description

Published

20090132334

System and Method for Estimating an Amount of Traffic Associated with a Digital Advertisement - Systems and methods for estimating an amount of traffic associated with a digital ad are disclosed. Generally, a forecasting module identifies a set of candidate webpages on which a digital ad may be displayed and estimates a click through rate associated with the digital ad and a webpage of the set of candidate webpages. The forecasting module determines a ranking score associated with the digital ad based on the determined click through rate and a bid price associated with the digital ad. The forecasting module then examines historical data, such as search logs, to determine an estimate of traffic associated with the digital ad with respect to the webpage in response to determining the ranking score of the digital ad exceeds a ranking score associated with another digital ad that was previously displayed on the webpage.

05-21-2009

Yichun Wang, West Roxbury, MA US

Patent application number

Description

Published

20110039148

ALKALINE PRIMARY CELLS - A battery is described. The battery includes an anode, a cathode, a separator disposed between the cathode and the anode, and an electrolyte. The anode further includes manganese.

02-17-2011

20110039149

ALKALINE PRIMARY CELLS - A battery is described. The battery includes an anode, a cathode, a separator disposed between the cathode and the anode, and an electrolyte. The cathode further includes manganese.

02-17-2011

20110039150

ALKALINE PRIMARY CELLS - A battery is described. The battery includes an anode, a cathode, a separator disposed between the cathode and the anode, and an electrolyte. The electrolyte further includes manganese. The manganese is selected from the group consisting of: cesium permanganate (CsMnO

PRIMARY ALKALINE BATTERY - A primary battery includes a cathode having a non-stoichiometric metal oxide including transition metals Ni, Mn, Co, or a combination of metal atoms, an alkali metal, and hydrogen; an anode; a separator between the cathode and the anode; and an alkaline electrolyte.

09-15-2011

20130036603

PRIMARY ALKALINE BATTERY - A primary battery includes a cathode having a non-stoichiometric metal oxide including transition metals Ni, Mn, Co, or a combination of metal atoms, an alkali metal, and hydrogen; an anode; a separator between the cathode and the anode; and an alkaline electrolyte.

02-14-2013

Patent applications by Yichun Wang, West Roxbury, MA US

Yifong Wang, Lexington, MA US

Patent application number

Description

Published

20090087888

PRODUCTION OF MONATIN STEREOISOMERS - Methods and materials for the production of the high intensity sweetener, monatin, in stereoisomerically-pure or stereoisomerically-enriched form are disclosed. For example, methods using stereoisoselective hydrolysis and separation of a monatin-derived lactone ester are disclosed.

04-02-2009

Yige Wang, Natick, MA US

Patent application number

Description

Published

20100058139

Method for constructing large-girth quasi-cyclic low-density parity-check codes - A method constructs a code, wherein the code is a large-girth quasi-cyclic low-density parity-check code. A base matrix is selected for the code. A cost matrix corresponding to the base matrix is determined. A single element in the base is changed repeatedly maximize a reduction in cost. A parity check matrix is constructing for the code from the base matrix when the cost is zero, and an information block is encoded as a code word using the parity check matrix in an encoder.

03-04-2010

20100077278

Method and System for Authenticating Reliable Biometric Data - A method for authenticating biometric data. Comprising of a processor that measures the reliability of each bit in enrollment biometric data; by arranging the bits; encoding the enrollment biometric data in the decreasing order to produce an enrollment syndrome; arranging the bits in the authentication biometric; decoding the authentication enrollment syndrome to produce an estimate of the enrollment biometric data; generating an output signal indicating that the estimate of the authentication biometric data is substantially the same as the enrollment biometric data.

03-25-2010

20100185870

Method and System for Managing a Hierarchy of Passwords - A method and system manage a hierarchy of passwords for users accessing a hierarchy of access control devices. First, a codeword is acquired and a syndrome of the codeword is determined. Next, the codeword is randomly modified with a probability p to produce a modified codeword. The modified codeword is selected and assigned to a user as a password, if the modified codeword is recoverable.

07-22-2010

20100192040

Multi-Stage Decoder for Error-Correcting Codes - A multi-stage decoder decodes a block of symbols, received via a noisy channel, to a codeword. The decoder includes multiple sub-decoders connected sequentially, and wherein a next sub-decoder has a slower processing time and better word error rate than a previous sub-decoder, and wherein the next sub-decoder is only executed if the previous decoder fails to decode the block sequence of symbols, and a last sub-decoder is executed until a termination condition is reached.

07-29-2010

20100263007

Method and Apparatus for Increasing Quality of IPTV Transmission - In a home network for Internet protocol (IP) television (IPTV), a controller of an IPTV-set-top box (STB) acquires and analyzes of an operation of the home network and data packets in the network. In a home gateway (HG), the statistics are received, and the packets are decoded, and then encodes into data packets, repair packets and according to the statistics to decrease packet loss. That is, the encoded packets have additional error correction codes.

Method and System for Harmonizing QoS in Home Networks - Packet in a multimedia stream has and associated standard priority level specified by standard protocols. The standard priority level in input packets received by a home gateway is converted to a harmonized priority level. Then, the input packets are processed in the home gateway according to the harmonized priority level, and converted from the harmonized priority level to the standard priority level in corresponding output packets after the processing.

06-16-2011

20120140829

Signal Coding Using Spatial Statistical Dependencies - An encoded signal is decoded based on statistical dependencies between the encoded signal and the side information. A statistical reliability of each transform block of the side information is determined as a function of absolute values of transform coefficients of a transform block. The transform blocks of the side information are grouped into a set of groups based on the statistical reliability of each transform block. The decoding is performed using a statistical dependency between a transform block of the encoded signal and a group including a corresponding transform block of the side information.

06-07-2012

20120140922

Method for Generating Private Keys in Wireless Networks - The first and second nodes in a wireless network estimate first and second channel response. The first node quantizes the first channel response to produce a first bit sequence, and a feed-forward message, which is transmit as a feed-forward message to the second node. The second node quantizes the second channel response using the feed-forward message to produce and an estimate of the first bit sequence, a second bit sequence and a feed-back message, which is transmitted to the first node. Then, the first and second nodes delete bits in the respective bit sequences using the feed-back and feed-forward message to generate first and second private keys with low bit mismatch rate.

06-07-2012

20120148046

Secure Wireless Communication Using Rate-Adaptive Codes - Data are communicated in a wireless network between a transmitter to a receiver. The transmitter estimates a first channel response between the receiver and the transmitter at the transmitter, and generating a first key based on the first channel response. The data are encoded at the transmitter using a rate-adaptive code to produce encoded data, which is scrambling using the first key before broadcasting. Subsequently, the receiver can estimate a second channel response to generate a second key to be used to descramble the broadcast data.

06-14-2012

20120207027

Method for Minimizing Undetectable Errors in Data Packets in Communication Systems - Undetectable errors in packets are minimized by verifying the CRC in each packet, setting a CRC flag to 0 to indicate success, and setting the CRC flag to 1 to indicate failure. If at least one packet in the set of packets fails then generate an error pattern E for each packet by comparing the packet that fails with one packet that passed the CRC verification, and comparing the error pattern to a set of known error patterns. Then, setting a CRC flag to 0 to indicate success and passing the payload of each packet and the CRC flag to the application if the difference is less than a predetermined threshold, and otherwise, setting the CRC flag to 1 to indicate failure.

08-16-2012

Patent applications by Yige Wang, Natick, MA US

Yigong Wang, Rutland, MA US

Patent application number

Description

Published

20100207222

Hall Effect Element Having a Hall Plate with a Perimeter Having Indented Regions - A Hall effect element includes a Hall plate with an outer perimeter. The outer perimeter includes four corner regions, each tangential to two sides of a square outer boundary associated with the Hall plate, and each extending along two sides of the square outer boundary by a corner extent. The outer perimeter also includes four indented regions. Each one of the four indented regions deviates inward toward a center of the Hall plate. The Hall plate further includes a square core region centered with and smaller than the square outer boundary. A portion of each one of the four indented regions is tangential to a respective side of the square core region. Each side of the square core region has a length greater than twice the corner extent and less than a length of each side of the square outer boundary.

Vertical Hall Effect Element with Improved Sensitivity - A vertical Hall Effect element includes a low voltage P-well region disposed at a position between pickups of a vertical Hall Effect element to result in an improved sensitivity of the vertical Hall Effect element. A method results in the vertical Hall Effect element having the improved sensitivity.

07-31-2014

20140264667

Vertical Hall Effect Element With Structures to Improve Sensitivity - A vertical Hall Effect element includes one or more of: a low voltage P-well region disposed at a position between pickups of the vertical Hall Effect element, Light-N regions disposed under the pickups, a pre-epi implant region, or two epi regions to result in an improved sensitivity of the vertical Hall Effect element. A method results in the vertical Hall Effect element having the improved sensitivity.

09-18-2014

Patent applications by Yigong Wang, Rutland, MA US

Yingpi Karen Wang, Boxborough, MA US

Patent application number

Description

Published

20100015652

ANTIBODY QUANTITATION - The invention relates to a novel method for determining the amount of an antibody of interest in a biological sample. In one embodiment, the method of the invention is characterized in that it comprises at least a step of protein depletion of said biological sample by pepsin digestion to produce F(ab)

01-21-2010

Yongzhong Wang, Melrose, MA US

Patent application number

Description

Published

20090136981

METHODS OF MEASURING CELL VIABILITY IN TISSUE ENGINEERED PRODUCTS - This invention provides methods of measuring the viability of cultured cells by detecting one or more cell death-stable proteins or enzyme activities. Methods provided by the invention correlate viability to relative levels of enzyme activity in cell-containing and non-cell-containing fractions of a cell culture.

05-28-2009

20120282640

METHODS OF MEASURING CELL VIABILITY IN TISSUE ENGINEERED PRODUCTS - This invention provides methods of measuring the viability of cultured cells by detecting one or more cell death-stable proteins or enzyme activities. Methods provided by the invention correlate viability to relative levels of enzyme activity in cell-containing and non-cell-containing fractions of a cell culture.

11-08-2012

20140273050

METHODS OF MEASURING CELL VIABILITY IN TISSUE ENGINEERED PRODUCTS - This invention provides methods of measuring the viability of cultured cells by detecting one or more cell death-stable proteins or enzyme activities. Methods provided by the invention correlate viability to relative levels of enzyme activity in cell-containing and non-cell-containing fractions of a cell culture.

09-18-2014

Patent applications by Yongzhong Wang, Melrose, MA US

Yuhu Wang, Littleton, MA US

Patent application number

Description

Published

20080308528

Nanoporous ultrafine alpha-alumina powders and sol-gel process of preparing same - The present invention provides α-alumina powders comprising α-alumina particles of which at least 80% of the α-alumina particles have a particle size of less than 100 nm. The invention also provides slurries, particularly aqueous slurries, which comprise α-alumina powders of the invention. The invention further provides methods of manufacturing α-alumina powders and α-alumina slurries of the invention and methods of polishing using same.

12-18-2008

Yundong Wang, Lancaster, MA US

Patent application number

Description

Published

20090186217

Article Comprising a Polymer Substrate and a Co-Extruded Polymer Coating - The present invention relates to an article comprising a polymer substrate and a co-extruded polymer coating. The polymer substrate is for example manufactured from a thermoset rubber, a styrene based thermoplastic elastomer, an olefinic based thermoplastic elastomer or mixtures of these polymers. The co-extruded coating comprises an optical brightener for example a fluorescent agent. The co-extruded coating for example has a thickness smaller than 700 micrometer. The article is for example used in automotive applications, in building and construction applications, in packaging, in food applications, consumer applications, in medical applications or in wire and cable applications. The present invention also relates to the use of the articles of the present invention in automotive sealing systems.

07-23-2009

20110294930

FLAME RETARDANT THERMOPLASTIC ELASTOMERS - The invention relates to a thermoplastic elastomer composition comprising a thermoplastic elastomer and a flame retardant, wherein the flame retardant comprises at least a compound selected from the group consisting of piperazine phosphate, piperazine pyrophosphate and piperazine polyphosphate, and a phosphoric acid compound.

12-01-2011

20140100310

THERMOPLASTIC ELASTOMER COMPOSITIONS HAVING BIORENEWABLE CONTENT - Thermoplastic elastomer compositions, in particular derived from one or more styrenic block copolymers, a plurality of biorenewable materials, preferably a softener and one or more synergistic additives such as a polar polymer; a synergistic block copolymer such as a relatively high molecular weight styrenic block copolymer; and/or filler. In one preferred embodiment, the styrenic block copolymer comprises a controlled distribution copolymer block including a conjugated diene and a mono alkenyl arene. Numerous desirable articles can be formed from the compositions. Processes for preparing the compositions and articles are disclosed.

04-10-2014

20140100311

THERMOPLASTIC ELASTOMER COMPOSITIONS HAVING BIORENEWABLE CONTENT - Thermoplastic elastomer compositions, in particular derived from one or more styrenic block copolymers wherein at least one styrenic block copolymer comprises a controlled distribution copolymer block including a conjugated diene and a mono alkenyl arene, a plurality of biorenewable materials, preferably a softener and one or more synergistic additives such as a polar polymer; a synergistic block copolymer such as a relatively high molecular weight styrenic block copolymer; and/or filler. Numerous desirable articles can be formed from the compositions. Processes for preparing the compositions and articles are disclosed.

04-10-2014

Patent applications by Yundong Wang, Lancaster, MA US

Yunyan Wang, Framingham, MA US

Patent application number

Description

Published

20110072137

INTEGRATED APPLICATION ACCESS - An integration portal provides a user with access to application entities of a plurality of remote applications. An authorization layer included in the integration portal includes a permission map indicating an association between the user and at least one of the application entities of the plurality of remote applications that the user is permitted to access. The authorization layer in the integration portal is synchronized with an authorization layer included in an application portal that provides the user with access to a subset of the remote applications, whereby the permission map is updated with information about at least one of the application entities that the user is permitted to access through the integration portal. Corresponding systems and methods are also disclosed.

03-24-2011

Yuxun Wang, Shrewsbury, MA US

Patent application number

Description

Published

20090142855

Polynucleotides and Polypeptides of the IL-12 Family of Cytokines - The present invention relates to the primate family of cytokines. Provided herein are polynucleotides encoding such polypeptides, and reagents useful for producing the encoded polypeptides in a host source, and for identifying compounds which bind and modulate the activity of the encoded polypeptides. Also provided are reagents useful for the diagnosis or treatment of inflammatory and/or autoimmune related diseases in primates.

06-04-2009

Zhaolin Wang, Wellesley, MA US

Patent application number

Description

Published

20090004108

Smmr (Small Molecule Metabolite Reporters) For Use As In Vivo Glucose Biosensors - Small Molecule Metabolite Reporters (SMMRs) for use as in vivo glucose biosensors, sensor compositions, and methods of use, are described. The SMMRs include boronic acid-containing xanthene, coumarin, carbostyril and phenalene-based small molecules which are used for monitoring glucose in vivo, advantageously on the skin.

01-01-2009

20140127137

SMMR (SMALL MOLECULE METABOLITE REPORTERS) FOR USE AS IN VIVO GLUCOSE BIOSENSORS - Small Molecule Metabolite Reporters (SMMRs) for use as in vivo glucose biosensors, sensor compositions, and methods of use, are described. The SMMRs include boronic acid-containing xanthene, coumarin, carbostyril and phenalene-based small molecules which are used for monitoring glucose in vivo, advantageously on the skin.

05-08-2014

Patent applications by Zhaolin Wang, Wellesley, MA US

Zhaoxi Wang, Chelmsford, MA US

Patent application number

Description

Published

20110086796

METHODS FOR PREDICTING THE DEVELOPMENT AND RESOLUTION OF ACUTE RESPIRATORY DISTRESS SYNDROME - The subject invention features methods for predicting whether a subject at risk of developing Acute Respiratory Distress Syndrome (ARDS) will develop ARDS by determining the amount of elafin present in a subject sample, or by determining the ration of elafin:neutrophil elastase in a subject sample. The invention also features methods for monitoring the efficacy of a treatment regimen for ARDS as well as methods of treatment for ARDS. The invention also features methods to determine a subject's predisposition for developing ARDS by determining whether certain genomic polymorphisms are present in the subject's DNA.

04-14-2011

Zhirui Wang, Malden, MA US

Patent application number

Description

Published

20110104789

NON-INTEGRATING REV-DEPENDENT LENTIVIRAL VECTOR AND METHODS OF USING THE SAME - Non-integrating, Rev-dependent (NIRD) lentiviral vectors and NIRD lentiviral particles carrying a therapeutic gene, such as DT-A or TRAF6 and methods of making the same are disclosed. The intracellular expression of DT-A or TRAF6 results in the selective killing of HIV-positive cells and, thus, these NIRD lentiviral vectors and lentiviral particles can be used in methods to kill HIV-infected cells or treat to HIV-infected subjects. Also disclosed is a human cell line comprising a mutation in the EF2 gene that confers resistance to DT-A.

05-05-2011

Zhongguo Wang, Lexington, MA US

Patent application number

Description

Published

20090209530

INHIBITORS OF CYCLIN-DEPENDENT KINASES, COMPOSITIONS AND USES RELATED THERETO - The invention pertains to novel cyclin dependent kinase inhibitors (cdks) and specifically, but not exclusively, as inhibitors of cdk/cyclin complexes. As described herein, the inhibitors of this invention are capable of inhibiting the cell-cycle machinery and consequently may be useful in modulating cell-cycle progression, ultimately controlling cell growth and differentiation. Such compounds would be useful for treating subjects having disorders associated with excessive cell proliferation.

08-20-2009

20100004207

Inhibitors of cyclin-dependent kinases, compositions and uses related thereto - The invention pertains to novel cyclin dependent kinase inhibitors (cdks) and specifically, but not exclusively, as inhibitors of cdk/cyclin complexes. As described herein, the inhibitors of this invention are capable of inhibiting the cell-cycle machinery and consequently may be useful in modulating cell-cycle progression, ultimately controlling cell growth and differentiation. Such compounds would be useful for treating subjects having disorders associated with excessive cell proliferation.

01-07-2010

20110046362

METHODS OF MAKING NUCLEOSIDE TETRAPHOSPHATE - The invention provides compounds and methods for making adenosine-ribofuranoside tetraphosphate compounds. The compounds are contemplated to have activity at the P2Y receptor and may be used in the treatment of medical disorders such as cystic fibrosis and upper respiratory disorders.