anti-Basigin (Ok Blood Group) (BSG) Antibodies

The protein encoded by BSG is a plasma membrane protein that is important in spermatogenesis, embryo implantation, neural network formation, and tumor progression. Additionally we are shipping CD147 Kits (69) and CD147 Proteins (38) and many more products for this protein.

Results demonstrated that CD147 serves a key role in melanoma cell apoptosis, which may be mediated via IGFBP2 and the PTEN/PI3K/AKT signaling pathway. In addition, the expression of IGFBP2 and CD147 was upregulated and exhibited a positive association in melanoma clinical tissues.

findings suggest that the OK/BSG expression levels on RBCs might be related to P. falciparum invasion

Silencing of CD147 in endothelial cells inhibited Human cytomegalovirus entry but not entry into fibroblasts.

CD147 and the beta2-adrenergic receptor form hetero-oligomeric complexes.Actinin-4 directly binds to the cytosolic tail of CD147 and governs the assembly of CD147-beta2-adrenergic receptor complexes in highly ordered clusters at bacterial adhesion sites.

Characterization of the role of CD147 in the development of tumors should lead to a better understanding of the changes occurring at the molecular level during the development and progression of primary human bone cancer.

Our results indicate that concomitant stimulation and colocalization of galectin-3 with CD147 are associated with increased gelatinolytic activity in the actively ulcerating human cornea

These findings reveal an important cytomegalovirus mechanism for evading antiviral innate immunity through its encoded microRNA US25-1-5p by targeting transmembrane glycoprotein CD147.

on a major part of fibroblastic cells in encapsulating peritoneal sclerosis

Mouse (Murine) Basigin (Ok Blood Group) (BSG) interaction partners

The fibroblast-specific deletion of Basigin did not influence the growth, fertility and the general condition of the mice. No obvious differences were found in the size, morphology, and histological structure of the major organs, including heart, liver, spleen, lung and kidney, between the knockout mice and the control mice. The deletion of Basigin in fibroblasts did not induce apoptosis in the tissues of the major organs

A new molecular mechanism for high angiogenic capacity, whereby microglia cells release basigin via up-regulation of PI3K-AKT and IGF-1 pathway to induce angiogenesis is unveiled.

EMMPRIN inhibited bFGF-induced IL-6 secretion by reducing the p65 subunit phosphorylation, it might be concluded that bFGF and EMMPRIN crosstalk in their respective signaling pathways.

protein-protein interaction studies on TRAF6 and BSG to get molecular level insights of the reactions.

This study has highlighted basigin as a common essential molecule for various stimuli-induced impairment of retinal vascular barrier, which can be a target for strategies to establish a curative treatment of diabetic retinopathy

Data show that caveolin-3 binds to low glycosylated extracellular matrix metalloproteinase inducer (LG-EMMPRIN) in cardiac cells and in the hearts of healthy mice.

These results suggest that basigin has a functional role as a binding partner with MCT2 in testicular and epididymal spermatozoa.

both caveolin-1 and EMMPRIN mRNA levels increased gradually with progression of developmental stages, and peaked at day two postnatal. The current finding suggests that both caveolin-1 and EMMPRIN take part in mouse tooth development, especially in the differentiation and organization of odontogenic tissues.

knockdown of CD147 on Hepa1-6 cells resulted in significantly increased T cells chemotaxis induced by CypA both in vivo and in vitro.

These findings indicate that TGF-beta1-CD147 loop plays a key role in regulating the HSC activation and combination of TGF-beta receptor inhibitor and anti-CD147 antibody might be promised to reverse fibrogenesis.

EMMPRIN promotes tumor growth and metastasis by recruitment of bone marrow-derived cells through controlling secretion and paracrine signaling of SDF-1 and VEGF.

Results indicate the crucial roles of intracellular and extracellular Bsg in the pathogenesis of cardiac hypertrophy, fibrosis, and failure.

Rabbit Basigin (Ok Blood Group) (BSG) interaction partners

CD147 is required for the expression of MCT1 and MCT4 in the corneal endothelium. Silencing CD147 slows lactate efflux, resulting in stromal lactate accumulation and corneal edema.

CD147 (BSG) Antigen Profile

Protein Summary

The protein encoded by this gene is a plasma membrane protein that is important in spermatogenesis, embryo implantation, neural network formation, and tumor progression. The encoded protein is also a member of the immunoglobulin superfamily. Multiple transcript variants encoding different isoforms have been found for this gene.