Not to mention 2 eyes appearing on opposite sides fo the room in the Depths 2 fight.

OH MY GOOOOOOOD
YOU KNOW those things on the side what about them? Womb/ovaries, we should ask him if he really did it to look like that. Ps. I never even thought about this, never made this association.

Meeting all those conditions implies getting a good run, which I just can't do.

My best Eve runs I simply play as if I were any other character.

I grab every chance to get more hearts and spirit hearts so it becomes very easy to make deals with the devil. At the first opportunity I get, I use a blood donation machine to get myself down to half a heart and then I sweep the rest of the game with Whore of Babylon active, a lot of extra money (which I can use to buy more upgrades), plus I have a few deals with the devil under my belt so I not only get those buffs, but I get an increased chance of encountering Krampus for even more damage upgrades.

I don't use the Razor Blade or Kamikaze that much unless I'm banking on using the Guppy exploit. And that's only if I have 0 spirit hearts, I don't want to waste them. As per usual, spirit hearts are the last thing I collect on a floor just in case I encounter a Guppy pickup and I have sufficient items to commit suicide 8 times from my current max health. Of course, unless I have a Fool, Stars, or Hermit tarot card, I will always pick everything I can up before I fight Mom in Depths 2 and Satan in Sheol (as I cannot backtrack in the former and backtracking in the latter is pointless). Telepills are another story, but I still pick all the spirit hearts up just in case I instead get sent to the I am error room.

First ??? Run -> Bag of Coins, Relic, Battery, and Book of Revelations by Caves 1, get Brimstone in devil room Caves 2... Beat everything including Satan :) (First run with the option of fighting satan, too)

It can appear in the treasure room, shop, beggar, devil room, and a reward for fighting the Fallen. I am unsure if it can appear in the Error room, and if it can appear as a boss fight (other than Fallen) reward is unknown since it's never happened.

Ah, I remember reading that article. My brother did some research into those, and claims they are blasphemous (heh), but I didn't read what he read, so I can't say for sure. Also, solid_jake, these are not nearly as many as there have been in the Bible, there have been many more given power directly from God.