The obesity epidemic is a significant global healthissue. Improved understanding of the mechanismsthat regulate appetite and body weight will providethe rationale for the design of anti-obesity therapies.Thyroid hormones play a key role in metabolichomeostasis through their interaction with thyroidhormone receptors (TRs), which function as ligand inducible transcription factors. The TR-beta isoform(TRb) is expressed in the ventromedial hypothalamus(VMH), a brain area important for control of energyhomeostasis. Here, we report that selective knockdownof TRb in the VMH of adult mice results in severeobesity due to hyperphagia and reduced energy expenditure. The observed increase in body weightis of a similar magnitude to murine models of themost extreme forms of monogenic obesity. Thesedata identify TRb in the VMH as a major physiologicalregulator of food intake and energy homeostasis.

The Potential of Omega-3 Supplementation to Reduce Muscle-Inflammation after Muscle-Damaging ExerciseKyriakidou, Y., Kantorovich, R.C., Bell, J.D., Monterisi, S. and Dolci, A. 2017. The Potential of Omega-3 Supplementation to Reduce Muscle-Inflammation after Muscle-Damaging Exercise. ACSM Annual Meeting, World Congress on Exercise is Medicine & World Congress on the Basic Science of Exercise and the Brain. Denver, Colorado 30 May - 03 Jun 2017 American College of Sports Medicine. doi:10.1249/01.mss.0000518523.15295.1c