Investigators at the National Institute of Neurological Disorders and Stroke (NINDS) conducting neurobehavioral studies seek
patients with progressive dementia diagnosed as Pick's disease, frontal lobe dementia, progressive aphasia, or lobar atrophy
of the frontal lobes. Patients with radiological evidence of focal atrophy of the frontal lobes are particularly needed.

Eligible patients must not have concurrent immune, respiratory, renal, hepatic, or gastrointestinal disease. Those enrolled
in the study will undergo neuropsychological testing and brain imaging studies. The studies will be conducted at the National
Institutes of Health (NIH) Clinical Center in Bethesda, MD. All study-related expenses will be paid by the NIH.