..The differences are more pronounced at the L1 and L2 loops of the respective monomers H2B and H2A, and at the N-termini of the monomers H3 and H4, all of which closely interact with the wrapping DNA...

..Z-H2B) dimer evidence their participation in the transcriptionally active state. The key role of variant H2A.Z histone as a major source of vibrant motions via weaker intra- and intermolecular correlations is emphasized in this chapter...

..Thus, the present study proposes a pharmacophore hypothesis representing the identified interactions pattern and its further application as a template in screening databases to identify novel VEGFR-2 inhibitor scaffolds. ..