All frescoes are as high finished as miniatures or enamels, and they are known to be unchangeable; but oil, being a body itself, will drink or absorb very little colour, and changing yellow, and at length brown, destroys every colour it is mixed with, especially every delicate colour. It turns every permanent white to a yellow and brown putty, and has compelled the use of that destroyer of colour, white lead, which, when its protecting oil is evaporated, will become lead again. This is an awful thing to say to oil painters ; they may call it madness, but it is true. All the genuine old little pictures, called cabinet pictures, are in fresco and not in oil. Oil was not used except by blundering ignorance till after Vandyke’s time ; but the art of fresco painting being lost, oil became a fetter to genius and a dungeon to art.

Amoeba has her picture in the book,Proud Protozoon!—Yet beware of pride,All she can do is fatten and divide;She cannot even read, or sew, or cook…The Worm can crawlBut has no eyes to look.The Jelly-fish can swimBut lacks a bride.

At the age of three I began to look around my grandfather’s library. My first knowledge of astronomy came from reading and looking at pictures at that time. By the time I was six I remember him buying books for me. … I think I was eight, he bought me a three-inch telescope on a brass mounting. … So, as far back as I can remember, I had an early interest in science in general, astronomy in particular.

Chemistry and physics are experimental sciences; and those who are engaged in attempting to enlarge the boundaries of science by experiment are generally unwilling to publish speculations; for they have learned, by long experience, that it is unsafe to anticipate events. It is true, they must make certain theories and hypotheses. They must form some kind of mental picture of the relations between the phenomena which they are trying to investigate, else their experiments would be made at random, and without connection.

During the time that [Karl] Landsteiner gave me an education in the field of imununology, I discovered that he and I were thinking about the serologic problem in very different ways. He would ask, What do these experiments force us to believe about the nature of the world? I would ask, What is the most. simple and general picture of the world that we can formulate that is not ruled by these experiments? I realized that medical and biological investigators were not attacking their problems the same way that theoretical physicists do, the way I had been in the habit of doing.

Facts alone, no matter how numerous or verifiable, do not automatically arrange themselves into an intelligible, or truthful, picture of the world. It is the task of the human mind to invent a theoretical framework to account for them.

From the rocket we can see the huge sphere of the planet in one or another phase of the Moon. We can see how the sphere rotates, and how within a few hours it shows all its sides successively ... and we shall observe various points on the surface of the Earth for several minutes and from different sides very closely. This picture is so majestic, attractive and infinitely varied that I wish with all my soul that you and I could see it. (1911)

I always feel like our descendants—they're going to be upset with us for wrecking the planet anyway—but they're really going to be mad that we didn't even bother to take a good picture. [On the importance of thorough research of even a little ant species.]

In this model, the sun is a very tiny speck of dust indeed—a speck less than a three-thousandth of an inch in diameter ... Think of the sun as something less than a speck of dust in a vast city, of the earth as less than a millionth part of such a speck of dust, and we have perhaps as vivid a picture as the mind can really grasp of the relation of our home in space to the rest of the universe.

Man tries to make for himself in the fashion that suits him best a simplified and intelligible picture of the world; he then tries to some extent to substitute this cosmos of his for the world of experience, and thus to overcome it. This is what the painter, the poet, the speculative philosopher, and the natural scientist do, each in his own fashion. Each makes this cosmos and its construction the pivot of his emotional life, in order to find in this way the peace and security which he cannot find in the narrow whirlpool of personal experience.

My picture of the world is drawn in perspective and not like a model to scale. The foreground is occupied by human beings and the stars are all as small as three-penny bits. I don't really believe in astronomy, except as a complicated description of part of the course of human and possibly animal sensation. I apply my perspective not merely to space but also to time. In time the world will cool and everything will die; but that is a long time off still and its present value at compound discount is almost nothing.

Science is a game—but a game with reality, a game with sharpened knives … If a man cuts a picture carefully into 1000 pieces, you solve the puzzle when you reassemble the pieces into a picture; in the success or failure, both your intelligences compete. In the presentation of a scientific problem, the other player is the good Lord. He has not only set the problem but also has devised the rules of the game—but they are not completely known, half of them are left for you to discover or to deduce. The experiment is the tempered blade which you wield with success against the spirits of darkness—or which defeats you shamefully. The uncertainty is how many of the rules God himself has permanently ordained, and how many apparently are caused by your own mental inertia, while the solution generally becomes possible only through freedom from its limitations.

Scientists [still] refuse to consider man as an object of scientific scrutiny except through his body. The time has come to realise that an interpretation of the universe—even a positivist one—remains unsatisfying unless it covers the interior as well as the exterior of things; mind as well as matter. The true physics is that which will, one day, achieve the inclusion of man in his wholeness in a coherent picture of the world.

So I want to admit the assumption which the astronomer—and indeed any scientist—makes about the Universe he investigates. It is this: that the same physical causes give rise to the same physical results anywhere in the Universe, and at any time, past, present, and future. The fuller examination of this basic assumption, and much else besides, belongs to philosophy. The scientist, for his part, makes the assumption I have mentioned as an act of faith; and he feels confirmed in that faith by his increasing ability to build up a consistent and satisfying picture of the universe and its behavior.

Television is too powerful a force for the public good to be stopped by misleading propaganda. No one can retard TV's advance any more than carriage makers could stop the automobile, the cable the wireless, or silent pictures the talkies.

The greatest of all spectral classifiers, Antonia Maury had two strikes on her: the biggest one was, she was a woman. A woman had no chance at anything in astronomy except at Harvard in the 1880’s and 1890’s. And even there, things were rough. It now turns out that her director, E.C. Pickering, did not like the way she classified; she then refused to change to suit him; and after her great publication in Harvard Annals 28 (1897), she left Harvard—and in a sense, astronomy. ... I would say the most remarkable phenomenological investigation in modern astronomy is Miss Maury’s work in Harvard Annals 28. She didn’t have anything astrophysical to go on. Investigations between 1890 and 1900 were the origin of astrophysics. But these were solar, mostly. And there Miss Maury was on the periphery. I’ve seen pictures of groups, where she’d be standing away a little bit to one side of the other people, a little bit in the background. It was a very sad thing. When Hertzsprung wrote Pickering to congratulate him on Miss Maury’s work that had led to Hertzsprung’s discovery of super giants, Pickering is supposed to have replied that Miss Maury’s work was wrong — could not possibly be correct.

The information reported in this section [about the two different forms, A and B, of DNA] was very kindly reported to us prior to its publication by Drs Wilkins and Franklin. We are most heavily indebted in this respect to the Kings College Group, and we wish to point out that without this data the formation of the picture would have been most unlikely, if not impossible.[Co-author with Francis Crick]

The laws of science are the permanent contributions to knowledge—the individual pieces that are fitted together in an attempt to form a picture of the physical universe in action. As the pieces
fall into place, we often catch glimpses of emerging patterns, called theories; they set us searching for the missing pieces that will fill in the gaps and complete the patterns. These theories, these provisional interpretations of the data in hand, are mere working hypotheses, and they are treated with scant respect until they can be tested by new pieces of the puzzle.

The picture of scientific method drafted by modern philosophy is very different from traditional conceptions. Gone is the ideal of a universe whose course follows strict rules, a predetermined cosmos that unwinds itself like an unwinding clock. Gone is the ideal of the scientist who knows the absolute truth. The happenings of nature are like rolling dice rather than like revolving stars; they are controlled by probability laws, not by causality, and the scientist resembles a gambler more than a prophet. He can tell you only his best posits—he never knows beforehand whether they will come true. He is a better gambler, though, than the man at the green table, because his statistical methods are superior. And his goal is staked higher—the goal of foretelling the rolling dice of the cosmos. If he is asked why he follows his methods, with what title he makes his predictions, he cannot answer that he has an irrefutable knowledge of the future; he can only lay his best bets. But he can prove that they are best bets, that making them is the best he can do—and if a man does his best, what else can you ask of him?

The picture of the natural world we all take for granted today, has one remarkable feature, which cannot be ignored in any study of the ancestry of science: it is a historical picture. [Co-author with June Coodfield]

The reason Dick's [Richard Feynman] physics was so hard for ordinary people to grasp was that he did not use equations. The usual theoretical physics was done since the time of Newton was to begin by writing down some equations and then to work hard calculating solutions of the equations. This was the way Hans [Bethe] and Oppy [Oppenheimer] and Julian Schwinger did physics. Dick just wrote down the solutions out of his head without ever writing down the equations. He had a physical picture of the way things happen, and the picture gave him the solutions directly with a minimum of calculation. It was no wonder that people who had spent their lives solving equations were baffled by him. Their minds were analytical; his was pictorial.

The search for extraterrestrial intelligence (SETI, to us insiders) has so far only proved that no matter what you beam up—the Pythagorean theorem, pictures of attractive nude people, etc.—the big 800 number in the sky does not return calls.

In Tarner Lecture, at Trinity College, Cambridge (Oct 1956), 'Science and Religion', printed in Mind and Matter (1958), 90. Also collected in What is Life?: With Mind and Matter and Autobiographical Sketches (1992, 2012), 154.

The sense that the meaning of the universe had evaporated was what seemed to escape those who welcomed Darwin as a benefactor of mankind. Nietzsche considered that evolution presented a correct picture of the world, but that it was a disastrous picture. His philosophy was an attempt to produce a new world-picture which took Darwinism into account but was not nullified by it.

The structure known, but not yet accessible by synthesis, is to the chemist what the unclimbed mountain, the uncharted sea, the untilled field, the unreached planet, are to other men … The unique challenge which chemical synthesis provides for the creative imagination and the skilled hand ensures that it will endure as long as men write books, paint pictures, and fashion things which are beautiful, or practical, or both.

The universe seems to me infinitely strange and foreign. At such a moment I gaze upon it with a mixture of anguish and euphoria; separate from the universe, as though placed at a certain distance outside it; I look and I see pictures, creatures that move in a kind of timeless time and spaceless space, emitting sounds that are a kind of language I no longer understand or ever register.

Until we consider animal life to be worthy of the consideration and reverence we bestow upon old books and pictures and historic monuments, there will always be the animal refugee living a precarious life on the edge of extermination, dependent for existence on the charity of a few human beings.

We have not known a single great scientist who could not discourse freely and interestingly with a child. Can it be that haters of clarity have nothing to say, have observed nothing, have no clear picture of even their own fields?

Remark made at age 3 years old after having just been photographed by her father, Edwin Land. Subsequently, he took a solitary walk while vacationing in Sante Fe (1943) and in that time originated the basic idea for the Polaroid instant camera. As quoted in 'Colossus of the Camera', New York Times (5 Aug 1982).

In science it often happens that scientists say, 'You know that's a really good argument; my position is mistaken,' and then they would actually change their minds and you never hear that old view from them again. They really do it. It doesn't happen as often as it should, because scientists are human and change is sometimes painful. But it happens every day. I cannot recall the last time something like that happened in politics or religion.
(1987) -- Carl Sagan