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World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar. Best Paper Award : Dr. Muhammad Baqir MR Fakhrildin
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Novel pyrazoline derivatives 4a-g , 5a-g , 8a-c , 9a-c and10a-c have been
synthesized starting from new α,β-unsaturated ketones 3a-g and 7a-c .All
the newly synthesized compounds have been characterized on the
basis of IR,1HNMR,Mass spectrometry,some representative
13CNMR and microanalysis as well as physical data. Some of the
newly synthesized compounds were evaluated for their in vitro
antimicrobial and antitumor activities.The antimicrobial activity was
screened against the organisms Escherichia coli as Gram-negative
bacteria, Streptococcus pneumoniae and Staphylococcus aureus as
Gram-positive bacteria and Aspragillus fumigatus and Candida
albicans as fungi.The best performance was found for the compounds
3g,4b,4e,4f, 5d,8c,10b and 10c. MIC values of all the active compounds
were comparable with the standard drug.Where compounds 3g and 4e
showed the highest antibacterial activity but compounds 10b and 10c exhibited the most
potent antifungal activity.The antitumor activity was investigated against human breast
carcinoma(MCF- 7) and colon carcinoma (HCT-116),Imatinib was used as positive
control.Among the tested compounds 4c and 5c displayed promising cytotoxic effect against
breast (MCF- 7) and colon (HCT-116) cell lines.Molecular docking studies were performed
to further support the highest potency of compounds 4c and 5c against breast and colon cell
lines.