The Boston Red Sox will open the 2017 Major League Baseball season against the Pittsburgh Pirates on April 3 at Fenway Park.

It’s the first time in six years that the Red Sox will open the regular season at home, and the interleague series also marks Pittsburgh’s second-ever trip to Fenway Park despite being a franchise for more than 100 years.

Two other series of note also include interleague play.

The Chicago Cubs, one of the most historic franchises in baseball history and favorites to win the 2016 World Series, will come to Boston for a three-game series in late April. The St. Louis Cardinals, who the Red Sox defeated in the 2004 and 2013 World Series, play a two-game series at Fenway in August.

Here’s the full 2017 schedule for the Red Sox.

The first Red Sox-Yankees games also are at Fenway Park, beginning April 25.