Former Saturday Night Live cast
member Jay Mohr wrote in
his book Gasping for
Airtime that, as guest host in October 1994, Tomei
insisted that a proposed sketch about another actress not be used
because she didn't like the idea of making fun of her, which
displeased the writers and performers, given the show's penchant
for satirizing celebrities.[9]

In 1996, Tomei made a guest appearance on the sitcom Seinfeld, playing
herself in the two-part episode "The Cadillac". In this episode,
George attempts to get a date with Tomei through a friend of
Elaine. She has also made an appearance on The Simpsons as
movie star Sara Sloane, who falls in love with Ned Flanders.

In 2006, Tomei had a recurring role on the TV series Rescue
Me, playing Johnny Gavin's ex-wife Angie.
She won a Gracie Allen Award for Supporting Actress in a Drama
Series for her work in the four episodes she appeared in.