Mouse (Murine) EH-Domain Containing 2 (EHD2) interaction partners

Assembly of EHD2 (show EHD3 Antibodies) stabilized and constrained caveolae to the plasma membrane to control turnover, and depletion of EHD2 (show EHD3 Antibodies), resulting in endocytic and more dynamic and short-lived caveolae.

The characterization of Fer1L5 and its interaction with EHD1 (show EHD1 Antibodies) and EHD2 (show EHD3 Antibodies) underscores the complex requirement of ferlin proteins and mediators of endocytic recycling for membrane trafficking events during myotube formation

appears to connect endocytosis to the actin cytoskeleton through interactions of its N-terminal domain with membranes and its C-terminal EH domain with the novel EHBP1 (show EHBP1 Antibodies) protein

EHD2 Antigen Profile

Protein Summary

This gene encodes a member of the EH domain-containing protein family. These proteins are characterized by a C-terminal EF-hand domain, a nucleotide-binding consensus site at the N terminus and a bipartite nuclear localization signal. The encoded protein interacts with the actin cytoskeleton through an N-terminal domain and also binds to an EH domain-binding protein through the C-terminal EH domain. This interaction appears to connect clathrin-dependent endocytosis to actin, suggesting that this gene product participates in the endocytic pathway.