New Amsterdam Genomics is
powerfulinsightfullife-changing

Scientific research linking genomic mutations to health properties is now growing faster than any one person can keep up with. Patients see these studies too and are asking their doctors how they can get their DNA analyzed. N.A.G. is the solution, a precision medicine platform that translates the latest scientific research into real clinical utility.

Transforming the Practice of Medicine

Traditional DNA tests suffer from many problems, including: 1) the scientific basis of their results is sometimes questionable, 2) there is not enough value for relatively healthy patients, and 3) there is often little a doctor can do to mitigate a patient's problem, if one is found.

N.A.G. has created a suite of technologies that overcome these limitations:

Whole Exome Sequencing
We analyze all 22,000 human genes. By contrast, older tests, such as 23andMe, do what is called genotyping, which is looking at DNA in just a few discrete places. Other tests, called gene panels, just look at a few genes. Our approach can provide a much broader view of the patient's genome.

Analytical Mastery
We detect point mutations, structural variations, copy number variations, and more. Our algorithms are sensitive enough to find mutations that may be unique to a specific individual. We can analyze the combined effect of multiple variations at different sites in the genome.

Mutation Database
We utilize an enormous and highly accurate database of the meaning of genomic mutations, giving you the smartest results. Our database is updated weekly to
ensure you're always current with the latest science.

Fast and Efficient
The average person has hundreds of thousands of mutations. Unbelievably, some DNA sequencing companies pore over each mutation one by one -- and expect you to spend time to do the same! N.A.G., by contrast, uses computer algorithms to prioritize DNA mutations and annotate them with useful information.

Supporting Research
N.A.G. provides tools enabling physicians to do research on the cases they see. We also offer data (with patient consent) to help researchers make new discoveries. See Researchers for more.

Validated and Trusted
Our entire testing methodology, including analytical performance and quality control, has been inspected and approved by CLIA (registration #22D2084314). We are also HIPAA compliant. Validation data on the performance of our tests and white papers on our impact are available upon request.

Patients Who May Benefit

Comprehensive

N.A.G. is potentially for everyone -- not just those who have illness. In fact, a significant percentage of patients who take our test receive a life changing report: they learn they have a mutation strongly linked to a disease. You as the physician can then potentially recommend increased screening, lifestyle adjustments, or other mitigation steps to promote wellness. Another valuable benefit for almost any patient are genomically derived medication selection and dosing guidelines.

Child

It is estimated that 10% of Americans have a rare genetic disease. N.A.G.'s exome sequencing can detect these early. For instance, in the case of a metabolic or lysosomal mutation, it may be critical to diagnose a child quickly to prevent premature mortality or life-long debilitation. For extra insight and to trace a mutation's origin, we often sequence the child's parents too, as a trio test. Since a person's DNA stays with them for life, sequencing your patients while they are young means they can benefit from their genomic information for the maximum amount of time.

Cancer

N.A.G.'s integrated germline and tumor sequencing solution takes cancer treatment to a new level of precision. Every patient and every tumor is genomically
unique, and cancer treatments can be designed to take advantage of this. Our test compares the genomes of the patient and their cancer to identify the important cancer-driving mutations, their implications, and therapeutic targets. Our approach helps oncologists structure regimens that have the best chance of achieving a meaningful response while minimizing toxicity.

Parent

Just because two parents are healthy does not mean their children face no genetic risk. Quite the opposite! In fact, a person generally carries numerous genetic defects that do not impact their own health but could combine with their partner's DNA to produce major diseases for their kids. Our test helps couples understand their risk so that they can make the best decisions about family planning.

All-Star Doctors

More than 500 doctors across the country use N.A.G. Here is what some of the best of the best say about us:

As a Family Medicine physician, I value actionable data when deciding on testing and when counseling my patients. New Amsterdam Genomics
scientific based expertise has allowed me to inform, educate and often times reassure my patients based on their genetic testing results. Using their online
resources, tools and actionable insight through data, helps my patients receive the most individualized care available / possible. NAG has truly allowed me to
redefine the letters PCP. I can now honestly say that I'm a Personalized Care Physician.

Dr. Geoffrey BurnsRenaissance Family Medicine -- Wellesley, MA

New Amsterdam Genomics exome sequencing is the beginning of the future standard in which patients will have a genetic blueprint to help
guide them and their physicians in day to day choices as well as customized plans for the prevention of illness. Beyond the strength of the technology, the
ongoing revision of relevance for each patient's data on newly published findings in the literature is a particularly appealing feature of their
program.

Dr. Dirk FraterE. Barrow Medical Group -- Dallas, TX

I find that my patients are excited about having their genome analyzed and having it explained to them in a clear and concise manner. We
are now able to determine hidden health risks so we can better advise our patients on potentially preventive therapies. And, the ability to learn of
pharmacogenetic issues that may guide us to alternative treatment options is priceless. This is one of the best preventive and discovery tools I have at my
disposal today.

Dr. Thom LobeRegeneveda -- Chicago, IL

The experience with NAG in my practice has been entirely positive. Patients are empowered to become more engaged in their health and their
future when they have the level of information that is available through genomic testing with NAG.

Dr. Edward S. GoldbergConcierge MD

Experience N.A.G. Yourself

We have observed that the doctors who are best able to explain the impact of precision medicine to their patients have experienced our test
themselves. Therefore, we invite you to get sequenced (at a special doctor rate). As an added incentive, one of our MDs or PhDs will personally
walk you through every detail of your results and answer any question you might have. Our goal is to make you fully capable of and confident in
incorporating genomics into your own care.

Start Today

We at N.A.G. want to help you enter the new world of precision medicine. Here is how to start:

Enter your contact information in the box below.

For our germline test, the patient submits saliva using a simple kit they can use at home. For our cancer test, we will coordinate with the necessary parties to obtain part of the patient's tumor tissue.

DNA is extracted from the specimen, and the sequence is determined in key regions. N.A.G. runs sophisticated algorithms on the data to uncover meaning and impact.

N.A.G. delivers you a report explaining your patient's unique findings. With your patient's genome decoded, you can devise ways to optimize their health.

I Want Precision Medicine!

Learn More

* A patient's genome alone does not typically provide the totality of information a doctor needs in order to provide the best care, treatment, or advice. Please also see the paragraph below.

This website is marketing material and so is less precise than the technical and legal information we require patients and doctors to read prior to testing. N.A.G. collects specimens using FDA approved devices. N.A.G. is not "direct to consumer." N.A.G. is ordered through a doctor, and N.A.G. results are intended to be interpreted by a doctor. (MA state law prohibits laboratories from performing tests without a written request from a licensed physician, dentist, or other authorized person.) N.A.G. is not a substitute for a doctor. Doctors, using the totality of information the situation affords them, are always responsible for the final decision as to caring for a patient. N.A.G. testing does not guarantee to improve a patient's health or any other specific outcome. N.A.G. has many limitations, including, but not limited to: we typically analyze just the 1% of the genome known as the exome; there is a probability that any portion of our advertised coverage region happens to be incompletely sequenced; there are types of genomic variation that exome sequencing is not ideal at detecting; measurement errors can happen; and basic science's understanding of the impact of the genome on human health is still evolving. Some jurisdictions have restrictions on testing.