Trimethobenzamide Hydrochloride Rectal suppository

Find a Physician

What is this medicine?

TRIMETHOBENZAMIDE (trye meth oh BEN za mide) helps to control nausea and vomiting after surgery. This medicine is also used to control nausea caused by stomach problems.

NOTE: This drug is no longer available in the United States. Patients currently using Trimethobenzamide suppositories should contact their prescriber about stopping this medicine and finding alternative therapies.

How should I use this medicine?

This medicine is for rectal use only. Do not take by mouth. Wash your hands before and after use. Take off the foil wrapping. Wet the tip of the suppository with cold tap water to make it easier to use. Lie on your side with your lower leg straightened out and your upper leg bent forward toward your stomach. Lift upper buttock to expose the rectal area. Apply gentle pressure to insert the suppository completely into the rectum, pointed end first. Hold buttocks together for a few seconds. Remain lying down for about 15 minutes to avoid having the suppository come out. Do not use more often than directed.

Talk to your pediatrician regarding the use of this medicine in children. While this medicine may be prescribed for certain conditions, precautions do apply. This medicine should not be used in infants or premature infants.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue

breathing problems

shakiness or tremors

seizures

severe or continuing vomiting

sore throat or fever

swelling of the hands and feet

tightness in the chest

yellowing of the eyes or skin

unusually tired

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

What should I watch for while using this medicine?

You may get drowsy or dizzy or have blurred vision. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may increase side effects of this medicine. Avoid alcoholic drinks.