Candidiasis - The angles of the mouth are also the places where intertriginous conditions favor the overgrowth of ubiquitous C. albicans, streptococci, staphylococci, and other ordinarily saprophytic but facultatively pathogenic microorganisms. These conditions are not to be confused with vitamin deficiencies, which are often overdiagnosed. Perlèche is more likely to be a mixed infection with C. albicans and bacteria. Therefore, treatment should be with a preparation that contains both an antimonilial agent like nystatin and a topical antibiotic. Candidal cheilitis is more difficult to treat and requires persistent application of a candicidal agent. Candidiasis in children with immunologic deficiency is particularly difficult to treat.