This paper discusses therapies that are experimental or that are not approved by the US Food and Drug Administration for the use under discussion.

ABSTRACTWhat should one do with a depressed patient who does not get better? If depression does not respond to an antidepressant given in adequate doses for an adequate time, logical next steps include increasing the dose, adding a different medication, or adding a nonpharmacologic therapy. Or one can reconsider the diagnosis.