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Katherine Heigl

She starred opposite Gerard Depardieu in My Father the Hero, was in the popular sci-fi drama Roswell, and can be seen as Dr. Isobel "Izzie" Stevens in the Golden Globe-winning series Grey's Anatomy. She was the female lead in the 2007 comedy hit Knocked Up, the 2008 chick flick 27 Dresses and the 2009 romantic comedy The Ugly Truth opposite Gerard Butler.