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DAMASCUS, Syria — President Bashar al-Assad vowed yesterday to “wipe out” Muslim extremists in Syria, blaming them for a suicide bombing at a mosque that killed dozens of people, including a top cleric who supported the embattled regime in the civil war.

The death toll from Thursday night’s bombing — the first suicide attack on a mosque in two years of violence in Syria — rose to 49 after seven of the wounded died overnight, the Health Ministry said.

Sheikh Mohammad Said Ramadan al-Buti, a top Sunni preacher, was killed as he was giving a sermon in the mosque in the heart of the capital, Damascus. The blast wounded nearly 80.

President Obama, standing with Jordan’s King Abdullah II in Amman yesterday, said the international community must work together to ensure there is a credible opposition ready to step into the breach.

“Something has been broken in Syria, and it’s not going to be put back together perfectly immediately — even after Assad leaves,” Obama said. “But we can begin the process of moving it in a better direction, and having a cohesive opposition is critical to that.”

Obama said Assad is sure to go but there is great uncertainty about what will happen after that.