"The entirety of the evidence must be reviewed in order to determine whether the claimed invention as a whole would have been obvious to a person of ordinary skill in the field." In re Kumar, 418 F.3d 1361, 1369 (Fed. Cir. 2005).

“[D]iscovery of an optimum value of a result effective variable in a known process is ordinarily within the skill of the art. . . . It is well settled that a prima facie case of obviousness may be rebutted ‘where the results of optimizing a variable, which was known to be result effective, (are) unexpectedly good.’” In re Boesch, 617 F.2d 272, 276 (CCPA 1980) (quoting In re Antonie, 559 F.2d 618, 620 (CCPA 1977)).