Some guys like the odd stuff. They are generally not for me. I like choosing calibers that are highly versatile and utilitarian. 357 and 44 mag will do about anything given the right bullet selection. Add a 22lr for cheap plinking and there is no handgun hunt in the world you can not undertake.

If I could only own 3 guns one handgun, shotgun and rifle it would be

4 in 357 mag.
700 rem in 308
and a 12ga that could take 3 1/2 mag

Not very exciting stuff but I would not feel under gunned anywhere in the world.
bottom line for me is though its your money and your hobby if you want to buy the most odd ball stuff you can find more power to ya! The variety of combinations and applications is what makes this such a great hobby.