Treatment with the cancer drugs decitabine and doxorubicin induces human skin keratinocytes to express Oct4 and the OCT4 regulator mir-145

The Journal of Dermatology, 04/13/2012Chinnathambi S et al.

The novel strategy presented here provides a regulatable system to produce Oct4+ cells for transformation studies and provides a unique method to study the effects of endogenous Oct4 in cancer cells and the surrounding somatic cells.