WARNING: RISK OF LACTIC ACIDOSIS. Serious side effects can happen in people taking JENTADUETO. Metformin, one of the medicines in JENTADUETO, can cause a rare but serious condition called lactic acidosis (a build-up of lactic acid in the blood) that can cause death. Lactic acidosis is a medical emergency and must be treated in a hospital. Stop taking JENTADUETO and call your doctor right away if you feel very weak or tired, have unusual muscle pain, have trouble breathing, are very sleepy, have sudden nausea and vomiting or diarrhea, feel cold, especially in your arms or legs, feel dizzy or lightheaded, or have a slow or irregular heartbeat, as these could be symptoms of lactic acidosis. Please see Important Safety Information and full Prescribing Information for complete Boxed Warning.

IS YOUR BLOOD SUGARHEADED IN THE RIGHT DIRECTION?

You try to exercise and eat well. But your A1C is still not at goal. It may be time to ask your doctor about JENTADUETO.

JENTADUETO is a prescription medicine that contains 2 diabetes medicines, linagliptin and metformin. JENTADUETO can be used along with diet and exercise to lower blood sugar in adults with type 2 diabetes when treatment with both linagliptin and metformin is appropriate.

JENTADUETO is not for people with type 1 diabetes or for people with diabetic ketoacidosis (increased ketones in the blood or urine).

If you have had inflammation of the pancreas (pancreatitis) in the past, it is not known if you have a higher chance of getting pancreatitis while you take JENTADUETO.

WHY JENTADUETO Could beRight For You

DOSING

A tablet that you take twice a day.

MAY LOWER BLOOD SUGAR

Along with exercise and a healthy diet, JENTADUETO could lower your blood sugar and A1C.

HOW DOES JENTADUETOWork?

JENTADUETO is a combination therapy that contains two diabetes medicines, linagliptin and metformin. Linagliptin belongs to a class of medicines called DPP-4 inhibitors, and metformin belongs to a class of medicines called biguanides.

DPP-4 inhibitors work by increasing hormones that stimulate your pancreas to produce more insulin and stimulate your liver to produce less glucose. Biguanides work by reducing the amount of glucose in your blood and by increasing insulin sensitivity.

The two medicines together, along with diet and exercise, can help your body produce more insulin, and less sugar. Managing your sugar can mean a lower A1C – and that's an important goal for anyone with type 2 diabetes.

HOW OFTEN DO YOU...

WHAT IS YOUR APPROXIMATE A1C?

What is the most important information I should know about JENTADUETO?

WARNING: RISK OF LACTIC ACIDOSIS

Serious side effects can happen in people taking JENTADUETO. Metformin, one of the medicines in JENTADUETO, can cause a rare but serious condition called lactic acidosis (a build-up of lactic acid in the blood) that can cause death. Lactic acidosis is a medical emergency and must be treated in a hospital.

Stop taking JENTADUETO and call your doctor right away if you feel very weak or tired, have unusual muscle pain, have trouble breathing, are very sleepy, have sudden nausea and vomiting or diarrhea, feel cold, especially in your arms or legs, feel dizzy or lightheaded, or have a slow or irregular heartbeat, as these could be symptoms of lactic acidosis.

You have a higher chance of getting lactic acidosis with JENTADUETO if you have kidney problems, liver problems, congestive heart failure that requires medicines, drink alcohol very often, or drink a lot of alcohol in short-term “binge” drinking, get dehydrated (lose a large amount of body fluids), have certain x-ray tests with dyes or contrast agents that are injected into your body, have surgery, have a heart attack, severe infection, or stroke, and are 80 years of age or older and have not had your kidneys tested.

Inflammation of the pancreas (pancreatitis) is another serious side effect that can happen to people taking JENTADUETO. Pancreatitis may be severe and lead to death. Before you start taking JENTADUETO tell your doctor if you have ever had pancreatitis, gallstones, a history of alcoholism, or high triglyceride levels.

Stop taking JENTADUETO and call your doctor right away if you have pain in your stomach area (abdomen) that is severe and will not go away. The pain may be felt going from your abdomen through to your back. The pain may happen with or without vomiting. These may be symptoms of pancreatitis.

Who should not take JENTADUETO?

Do not take JENTADUETO if you:

have kidney problems.

have a condition called metabolic acidosis or diabetic ketoacidosis (increased ketones in the blood or urine).

are allergic to linagliptin, metformin or any of the ingredients in JENTADUETO. Symptoms of an allergic reaction may include rash, itching, flaking or peeling; raised red patches on your skin (hives); and swelling of your face, lips, tongue and throat that may cause difficulty breathing or swallowing. If you have any symptoms of a serious allergic reaction, stop taking JENTADUETO and call your doctor or go to the emergency room right away.

What should I tell my doctor before using JENTADUETO?

Before you take JENTADUETO, tell your doctor if you:

have or have had inflammation of your pancreas (pancreatitis).

have kidney problems.

are going to get an injection of dye or contrast agents for an x-ray procedure. JENTADUETO will need to be stopped for a short time. Talk to your doctor about when you should stop JENTADUETO and when you should start JENTADUETO again.

have liver problems.

have heart problems, including congestive heart failure.

drink alcohol very often, or drink a lot of alcohol in short-term "binge" drinking.

have any other medical conditions.

are pregnant or planning to become pregnant. It is not known if JENTADUETO will harm your unborn baby.

are breast-feeding or plan to breast-feed. It is not known if JENTADUETO passes into your breast milk.

are older than 80 years; you should not take JENTADUETO unless your kidneys have been checked and they are normal.

Tell your doctor about all the medicines you take, including prescription and over‑the‑counter medicines, vitamins, and herbal supplements. JENTADUETO may affect the way other medicines work, and other medicines may affect how JENTADUETO works. Especially tell your doctor if you take

other medicines that can lower your blood sugar. If you take JENTADUETO with another medicine that can cause low blood sugar, such as sulfonylurea or insulin, your risk of getting low blood sugar is higher. The dose of your sulfonylurea or insulin may need to be lowered while you take JENTADUETO.

rifampin (Rifadin®, Rimactane®, Rifater®, Rifamate®)*, an antibiotic that is used to treat tuberculosis.

*These trademarks are owned by third parties not affiliated with JENTADUETO.

What are the possible side effects of JENTADUETO?

JENTADUETO may cause serious side effects, including

Lactic acidosis (a build-up of lactic acid in the blood).

Inflammation of the pancreas (pancreatitis).

Low blood sugar (hypoglycemia), especially if you take JENTADUETO with another medicine that can cause low blood sugar. Signs and symptoms of low blood sugar may include headache, irritability, drowsiness, hunger, weakness, fast heartbeat, dizziness, sweating, confusion, or feeling jittery.

Allergic (hypersensitivity) reactions can happen after your first dose or up to 3 months after starting JENTADUETO. Symptoms may include swelling of your face, lips, throat, and other areas on your skin; difficulty with swallowing or breathing; raised, red areas on your skin (hives); skin rash, itching, flaking, or peeling.

Joint pain. Some people who take medicines called DPP-4 inhibitors, one of the medicines in JENTADUETO, may develop joint pain that can be severe. Call your doctor if you have severe joint pain.

The most common side effects of JENTADUETO include stuffy or runny nose, sore throat, and diarrhea.

These are not all the possible side effects of JENTADUETO. For more information, ask your doctor or pharmacist. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1‑800‑FDA‑10881‑800‑FDA‑1088.

What is JENTADUETO?

JENTADUETO is a prescription medicine that contains 2 diabetes medicines, linagliptin and metformin. JENTADUETO can be used along with diet and exercise to lower blood sugar in adults with type 2 diabetes when treatment with both linagliptin and metformin is appropriate.

JENTADUETO is not for people with type 1 diabetes or for people with diabetic ketoacidosis (increased ketones in the blood or urine).

If you have had inflammation of the pancreas (pancreatitis) in the past, it is not known if you have a higher chance of getting pancreatitis while you take JENTADUETO.

Replacement Card

If you are already enrolled in the JENTADUETO Savings Card Program and need a replacement card, please call the JENTADUETO Savings Card Program at 1‑877‑512‑42461‑877‑512‑4246. Our customer service representatives are available to assist you.

Important Safety Information and Indication

What is the most important information I should know about JENTADUETO?

WARNING: RISK OF LACTIC ACIDOSIS

Serious side effects can happen in people taking JENTADUETO. Metformin, one of the medicines in JENTADUETO, can cause a rare but serious condition called lactic acidosis (a build-up of lactic acid in the blood) that can cause death. Lactic acidosis is a medical emergency and must be treated in a hospital.

Stop taking JENTADUETO and call your doctor right away if you feel very weak or tired, have unusual muscle pain, have trouble breathing, are very sleepy, have sudden nausea and vomiting or diarrhea, feel cold, especially in your arms or legs, feel dizzy or lightheaded, or have a slow or irregular heartbeat, as these could be symptoms of lactic acidosis.

You have a higher chance of getting lactic acidosis with JENTADUETO if you have kidney problems, liver problems, congestive heart failure that requires medicines, drink alcohol very often, or drink a lot of alcohol in short-term “binge” drinking, get dehydrated (lose a large amount of body fluids), have certain x-ray tests with dyes or contrast agents that are injected into your body, have surgery, have a heart attack, severe infection, or stroke, and are 80 years of age or older and have not had your kidneys tested.

Inflammation of the pancreas (pancreatitis) is another serious side effect that can happen to people taking JENTADUETO. Pancreatitis may be severe and lead to death. Before you start taking JENTADUETO tell your doctor if you have ever had pancreatitis, gallstones, a history of alcoholism, or high triglyceride levels.

Stop taking JENTADUETO and call your doctor right away if you have pain in your stomach area (abdomen) that is severe and will not go away. The pain may be felt going from your abdomen through to your back. The pain may happen with or without vomiting. These may be symptoms of pancreatitis.

Who should not take JENTADUETO?

Do not take JENTADUETO if you:

have kidney problems.

have a condition called metabolic acidosis or diabetic ketoacidosis (increased ketones in the blood or urine).

are allergic to linagliptin, metformin or any of the ingredients in JENTADUETO. Symptoms of an allergic reaction may include rash, itching, flaking or peeling; raised red patches on your skin (hives); and swelling of your face, lips, tongue and throat that may cause difficulty breathing or swallowing. If you have any symptoms of a serious allergic reaction, stop taking JENTADUETO and call your doctor or go to the emergency room right away.

What should I tell my doctor before using JENTADUETO?

Before you take JENTADUETO, tell your doctor if you:

have or have had inflammation of your pancreas (pancreatitis).

have kidney problems.

are going to get an injection of dye or contrast agents for an x-ray procedure. JENTADUETO will need to be stopped for a short time. Talk to your doctor about when you should stop JENTADUETO and when you should start JENTADUETO again.

have liver problems.

have heart problems, including congestive heart failure.

drink alcohol very often, or drink a lot of alcohol in short-term "binge" drinking.

have any other medical conditions.

are pregnant or planning to become pregnant. It is not known if JENTADUETO will harm your unborn baby.

are breast-feeding or plan to breast-feed. It is not known if JENTADUETO passes into your breast milk.

are older than 80 years; you should not take JENTADUETO unless your kidneys have been checked and they are normal.

Tell your doctor about all the medicines you take, including prescription and over‑the‑counter medicines, vitamins, and herbal supplements. JENTADUETO may affect the way other medicines work, and other medicines may affect how JENTADUETO works. Especially tell your doctor if you take

other medicines that can lower your blood sugar. If you take JENTADUETO with another medicine that can cause low blood sugar, such as sulfonylurea or insulin, your risk of getting low blood sugar is higher. The dose of your sulfonylurea or insulin may need to be lowered while you take JENTADUETO.

rifampin (Rifadin®, Rimactane®, Rifater®, Rifamate®)*, an antibiotic that is used to treat tuberculosis.

*These trademarks are owned by third parties not affiliated with JENTADUETO.

What are the possible side effects of JENTADUETO?

JENTADUETO may cause serious side effects, including

Lactic acidosis (a build-up of lactic acid in the blood).

Inflammation of the pancreas (pancreatitis).

Low blood sugar (hypoglycemia), especially if you take JENTADUETO with another medicine that can cause low blood sugar. Signs and symptoms of low blood sugar may include headache, irritability, drowsiness, hunger, weakness, fast heartbeat, dizziness, sweating, confusion, or feeling jittery.

Allergic (hypersensitivity) reactions can happen after your first dose or up to 3 months after starting JENTADUETO. Symptoms may include swelling of your face, lips, throat, and other areas on your skin; difficulty with swallowing or breathing; raised, red areas on your skin (hives); skin rash, itching, flaking, or peeling.

Joint pain. Some people who take medicines called DPP-4 inhibitors, one of the medicines in JENTADUETO, may develop joint pain that can be severe. Call your doctor if you have severe joint pain.

The most common side effects of JENTADUETO include stuffy or runny nose, sore throat, and diarrhea.

These are not all the possible side effects of JENTADUETO. For more information, ask your doctor or pharmacist. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1‑800‑FDA‑10881‑800‑FDA‑1088.

What is JENTADUETO?

JENTADUETO is a prescription medicine that contains 2 diabetes medicines, linagliptin and metformin. JENTADUETO can be used along with diet and exercise to lower blood sugar in adults with type 2 diabetes when treatment with both linagliptin and metformin is appropriate.

JENTADUETO is not for people with type 1 diabetes or for people with diabetic ketoacidosis (increased ketones in the blood or urine).

If you have had inflammation of the pancreas (pancreatitis) in the past, it is not known if you have a higher chance of getting pancreatitis while you take JENTADUETO.

Replacement Card

If you are already enrolled in the JENTADUETO Savings Card Program and need a replacement card, please call the JENTADUETO Savings Card Program at 1‑877‑512‑42461‑877‑512‑4246. Our customer service representatives are available to assist you.

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