Editor's comment: Postural Tachycardia Syndrome (POTS), a form of orthostatic intolerance, often occurs with fibromyalgia and ME/CFS. Since serotonin and norepinephrine reuptake inhibitors like Cymbalta and Savella are frequently prescribed for fibromyalgia, it is important to know that they may worsen POTS symptoms.

I am just curious if SNRI's would also have the same effect on POTS symptoms? I am on Effexor XR and have been diagnosed with POTS and CFIDS. I have not noticed any major issues, but have not been on it that long. Does anyone have info on SNRI's?