Background & Aims: Primary infertility may affect communication skills, ‎occupational and physical health of women. The purpose of this research was to investigate the impact of ‎primary infertility on different domains of life quality in an Iranian community. ‎

Materials & Methods: The research was performed on 60 primary infertile women seeking infertility treatment and 60 fertile women with similar sociodemographic characteristics. World Health Organization’s QOL-BREF ‎questionnaire was used to investigate health related life quality.

Results: The sociodemographic characteristics between two groups were similar with no ‎significant difference, except menstruation. Compared with the fertile women, the women with primary infertility had significantly lower ratios of quality of life in both physical (P=0.04) and psychological (P=0.01) domains. There was no difference in physical and environmental domains of life quality between two groups.‎

Conclusion: Women with primary infertility need psychological and social support to improve their life quality.