URMC Research Network

Pregnancy-Associated Plasma Protein-A

"Pregnancy-Associated Plasma Protein-A" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.

A product of the PLACENTA, and DECIDUA, secreted into the maternal circulation during PREGNANCY. It has been identified as an IGF binding protein (IGFBP)-4 protease that proteolyzes IGFBP-4 and thus increases IGF bioavailability. It is found also in human FIBROBLASTS, ovarian FOLLICULAR FLUID, and GRANULOSA CELLS. The enzyme is a heterotetramer of about 500-kDa.

This graph shows the total number of publications written about "Pregnancy-Associated Plasma Protein-A" by people in the URMC Research Network by year, and whether "Pregnancy-Associated Plasma Protein-A" was a major or minor topic of these publication.

Below are the most recent publications written about "Pregnancy-Associated Plasma Protein-A" by people in Profiles.