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VANCOUVER, British Columbia, Oct. 01, 2018 (GLOBE NEWSWIRE) -- Qu Biologics Inc. (Qu), a biopharmaceutical company developing Site Specific Immunomodulators (SSIs), a unique platform of immunotherapies designed to restore the body’s innate immune system, and scientists at the University of British Columbia have demonstrated Qu’s gut-targeted SSI, QBECO, improves barrier function and disease pathology in experimental models of ulcerative colitis and in patients with the disease. These findings were published last week in Frontiers in Immunology.

Ulcerative colitis (UC), like Crohn’s disease (CD), is a chronic life-long inflammatory disease of the gastrointestinal (GI) tract. However, unlike CD, mucosal inflammation in UC is limited to the colon (also known as the large intestines). Current treatment strategies for CD and UC are focused on symptom management by aggressive immune suppression to dampen inflammation. However, despite the growing arsenal of immunosuppressive agents, disease progression has not changed for the majority of UC patients, who often require surgery. With QBECO, Qu Biologics is approaching the treatment of inflammatory bowel disease in a completely different way with the goal of changing the trajectory of disease progression. Instead of suppressing immune function, QBECO aims to restore innate immune function in the GI tract to rebuild barrier function and clear the dysbiosis/bacterial infection that underlies the chronic inflammation that is characteristic of the disease. QBECO is made from an inactivated GI pathogen that is easily self-administered by the patient and is a first-in-class immunotherapy.

This collaborative translational research demonstrated that QBECO treatment successfully reduced disease pathology and promoted mucosal healing by activating productive innate immune responses in the GI tract. Senior author of the study, Dr. Bruce Vallance (Professor of Gastroenterology, University of British Columbia) explained, "Most patients with UC are given immunosuppressive therapies to control their disease. Our studies show that some patients benefit from the immune stimulation offered by Qu's microbial-based therapy. These findings are exciting and offer a new paradigm for our understanding and treatment of UC." Co-author and Qu’s Director of Scientific Innovation, Dr. Shirin Kalyan, added, “What is particularly encouraging is the fact that we may have a new treatment for people living with inflammatory bowel disease that does not entail life-long immune suppression and its consequences, which include increased risk of infections and certain cancers. We are hopeful that by restoring GI barrier function instead of suppressing the immune system we can achieve better long-term health outcomes for patients.”

“We demonstrated mucosal and histological improvement in 55% of UC patients by endoscopy, demonstrating a healing effect with QBECO treatment,” said Dr. Hal Gunn, CEO of Qu Biologics. “We are hopeful that we will demonstrate similar endoscopic healing results in our new CD study which is now enrolling patients.”

For more information about Qu Biologics and the science behind SSIs, please visit www.qubiologics.com.

About Qu Biologics Qu Biologics is a Vancouver-based private clinical stage biopharmaceutical company developing Site Specific Immunomodulators (SSI), a novel class of immunotherapies. SSIs are designed to stimulate an innate immune response in targeted organs or tissues to reverse the chronic inflammation underlying many conditions including cancer, inflammatory bowel disease, inflammatory lung disease and arthritis. SSIs are a broad platform technology being tested in multiple disease indications, including Health Canada approved clinical trials in lung cancer, Crohn’s disease and Ulcerative Colitis.

Backed by a prestigious group of scientific advisors and board members, Qu Biologics is led by a management team that includes co-founder and CEO Dr. Hal Gunn, a physician and expert on the body’s immune response to chronic disease; and Chief Medical Officer Dr. Simon Sutcliffe, former CEO of the BC Cancer Agency and a distinguished clinician, scientist and leader in cancer control in Canada and internationally.

Qu Biologics Inc. cautions you that statements included in this press release that are not a description of historical facts may be forward-looking statements. Forward-looking statements are only predictions based upon current expectations and involve known and unknown risks and uncertainties. You are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date of release of the relevant information, unless explicitly stated otherwise. Actual results, performance or achievement could differ materially from those expressed in, or implied by, Qu Biologics’ forward-looking statements due to the risks and uncertainties inherent in Qu Biologics’ business including, without limitation, statements about: the progress and timing of its clinical trials; difficulties or delays in development, testing, obtaining regulatory approval, producing and marketing its products; unexpected adverse side effects or inadequate therapeutic efficacy of its products that could delay or prevent product development or commercialization; the scope and validity of patent protection for its products; competition from other pharmaceutical or biotechnology companies; and its ability to obtain additional financing to support its operations. Qu Biologics does not assume any obligation to update any forward-looking statements except as required by law.

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