Drug Reference

Patent Ductus Arteriosus (PDA) in Premature Infants

Your infant has been diagnosed with a patent ductus arteriosus (PDA). The ductus arteriosus is a normal structure in a fetus’ heart before birth. It’s a blood vessel that connects 2 arteries: the pulmonary artery and the aorta. The pulmonary artery carries blood from the heart to the lungs. The aorta carries blood from the heart to the body. Before birth, the ductus arteriosus allows blood from the right ventricle to bypass the lungs because the fetus gets oxygen from the mother. The ductus arteriosus normally closes shortly after birth once the baby breathes on its own. It’s called a PDA when it stays open (patent). A PDA can lead to worsening heart function over time. But it can be easily treated. In the United States, this is a fairly common congenital (present at birth) heart defect. A PDA is more common in premature infants, but can also be seen in full-term infants. It may be associated with other congenital heart defects. It is more common in girls.

When is the PDA a problem?

A PDA that remains open beyond a few days after birth can strain the heart and increase the blood pressure in the lungs. This can causes fluid to build up in the lungs (pulmonary congestion) and may make it hard for the baby to breathe. The heart also has to work harder.

How is PDA diagnosed?

The problem can be detected with an echocardiogram. This is an ultrasound imaging test of the baby’s heart. In mild cases, there may be no symptoms. Or symptoms can include:

A heart murmur

Poor growth or weight gain

Sweating during feeding

Rapid or trouble breathing

Decreased exercise tolerance in the older child

How is PDA treated?

The ductus may close on its own, without treatment. If it doesn’t, treatments include:

Medicine. Certain medicines such as non-steroidal anti-inflammatory drugs (NSAIDs) can narrow the artery. This shrinks the duct and allows it to close. The medicine is given by IV or mouth over a period of a few days. During this time, the baby is watched closely.

Catheter-based procedure. This is usually done on older or larger babies. This may be done on a small- to moderate-sized PDAs if the treatment with medicine did not work. Children must be large enough to qualify for the procedure. A long thin tube (catheter) is inserted into a larger artery in the leg. A small metal coil or device is pushed through the catheter to the PDA. It is placed like a plug to block blood flow between the vessels. The coil or device is released and stays there long term (permanently).

Surgery. This may be done if your baby can’t tolerate the medicine, or if treatment with medicine has not worked. Typically it is done on children who are too small for a catheter-based procedure, or if a catheter-based procedure was not successful. The surgeon may advise surgery if other related congenital heart defects need surgery. The surgeon makes a cut (incision) between the ribs on the left side of the chest and clamps or ties off the opening in the blood vessel. The surgery doesn’t involve the heart muscle. This surgery has a high success rate and a low risk for complications.

What are the long-term effects?

Once the ductus is closed, there are rarely long-term complications. After closure using catheter-based procedures, preventive antibiotics may be given to prevent infection when your child has other procedures like dental work. Ask your cardiologist about what activities are safe for your baby.