On Focus

Quick Map

Search Database

This job proposal is a PhD position in our laboratory. The PhD will be hired in the context of an Initial Training Network (ITN) of the 7th
PCRD involving 11 European research groups working on viral entry. Our laboratory is studying the cellular processes involved in the initial steps of rabies virus infectious cycle. We would like to investigate the entry pathway of the virus in neurons and how the nucleocapsid travels all along the axons toward the cellular body. We also would like to identify the molecular mechanisms of the formation of the so-called Negri bodies that are micrometric cytoplasmic structures formed during infection and that we have recently demonstrated to be viral factories (Lahaye et al., J Virol. 2009, 83, 7948-58). Using different approaches (immunofluorescence, live imaging using recombinant fluorescent rabies viruses), the PhD student will dissect the initial steps of rabies virus cycle (from receptor binding to formation of the initial Negri bodies) in cell culture, neuroblastoma and neurons in primary culture. Proficiency in cellular virology, cellular biology and cellular imaging would be an advantage. More details and informations on our group and laboratory: http://www.vms.cnrs-gif.fr/site/pages/equipe_rhabdovirusEn.htm