Research: SIV does not influence PCV2 replication

The researchers from the Indiana-based university's Department of Comparative Pathobiology write in their abstract that Porcine Circovirus type 2 (PCV2) and swine influenza virus (SIV) are important pathogens for Porcine Respiratory Disease Complex (PRDC), which is economically significant worldwide.

They continued, "The pathogenesis of PCV2-SIV coinfection is unknown. In this study, we focused on establishing a challenge model for PCV2 to determine whether SIV influences PCV2 replication and increases the severity of PCV2-associated disease."

Inoculation
"Caesarean-derived colostrum-deprived pigs were inoculated intratracheally with cell culture medium only (negative control group), PCV2 only, or PCV2 followed one week later with SIV H1N1. Two pigs from each group were necropsied at 12, 21, 28, and 35 days after inoculation.

"Coinfection with SIV did not increase the number of PCV2 genomic copies in serum or target tissues or the severity of microscopic lesions associated with PCV2 in lung or lymph node. The antibody titre to PCV2 did not differ significantly between PCV2-SIV- and PCV2-infected groups."