Spring 2008, Biol 241Final exam1. Which twoof the following phrases briefly describe Mendel’s first and second laws?A)Equal segregation of allelesB)Discontinuous (no blending) variation of traitsC)Independent assortmentD)Dominance and recessivenessE)Homozygous and heterozygous2. A circular DNA molecule is subjected to single and double digestions with restriction enzymes, and the products are separated by gel electrophoresis. The results are given below (fragment size in kb):If this plasmid is digested with EcoRI, HindIII, and BamHI, what are the sizes of the fragments when separated by gel electrophoresis?3. This plasmid is digested with EcoRI, HindIII, and BamHI, and separated by gel electrophoresis. The bands are then blotted onto a membrane and hybridized with a radioactively labeled probe, made by using the 4kb fragment from the EcoR1 digest. Which band(s) will be detected in this Southern blot?2

Spring 2008, Biol 241Final exam4. If a wing-less male fly is crossed with a wing-less female fly and all progeny have wings, you could conclude:5. In mice, a short-tailed mutant was discovered. When it was crossed to a normal long-tailed mouse, 4 offspring were short-tailed and 3 were long-tailed. Two short-tailed mice form the F1generation were selected and crossed. They produced 6 short-tailed and 3 long-tailed mice. These genetic experiments were repeated three times with approximately the same results. What is the mode of inheritance?A)Incomplete penetranceB)Recessive epistasisC)Dominant epistaissD)Recessive lethalityE)X-linked trait

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