Non-adherence policy

Having worked out how to make non-adherent primary cells amenable to microscopy, Allcyte GmbH has created a platform for imaging interactions between T cells and B cells that can predict drug responses in hematological cancers.

COO Nikolaus Krall said Allcyte’s approach of studying drug responses in both cancer and immune cells provides more accurate predictions of responses than methods that rely solely on cell lines or primary cancer cells. “Our cultures are as close to a recapitulation of a functional immune system as you could wish for. We can look at how cells talk to each other by measuring their physical interactions.”

Unlike cell lines and primary solid tumor cells, liquid cancer cells don’t adhere well to solid surfaces, making them difficult to culture in monolayers or otherwise immobilize. As a result, the cells must be analyzed with solution-based methods,...