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Born in Nairobi, Kenya, to parents originally from Goa, India, deSouza moved to London, England when he was seven, and was educated in both the UK and the United States.[2] A traveler and member of an increasingly cross-national, global culture since birth, deSouza engages with issues of migration, relocation, and international travel in much of his work.[3][4][5] The inheritor of the ideas and issues of colonialism and postcolonialism, his photoworks, texts, and installations re-examine historically-fraught meanings of geography, culture, and personal and communal identity.[6][7] Much of his work takes up themes and visual vocabulary of migration and diaspora; his series of photographic work, The World Series, for example, was created as a response to Jacob Lawrence’s The Migration Series.[8][9][10][11] DeSouza’s interest in movement, travel and dislocation has provoked an engagement with memory and the passage of time in his work.[12][13] For the photographic series The Lost Pictures, DeSouza placed a number of slides of old family photos around his house, deliberately allowing them to become scratched, faded, and covered in dust.[14][15] Desouza’s work, in the words of one critic, “explores...both memory and photography as means of recording and preserving the past from aging, loss, displacement, and historical change.”[16][17] Although often based in historical figures or events, his work also incorporates "fiction, erasure, re-inscription, and (mis)translation".[1]

2010-2011: Krannert Art Museum at the University of Illinois, The Farthest Point, Urbana-Champaign, Illinois, US[26] 2008: Talwar Gallery, (i don't care what you say) Those Are Not Tourist Photos, New York, NY, US[5]

2005: Talwar Gallery, The Lost Pictures, New York, NY, US[27] 2003: Talwar Gallery, people in white houses, New York, NY, US[28] 2001: Art in General, Terrain, New York, NY, US