Figure 7

Pentamers within the HSEs are dependent upon their consensus match and also their position relative to the other pentamers.

A) The mixture model defines each pentamer within the HSE as strict or relaxed depending upon how well it conforms to the canonical HSE. Note that the position of relaxed pentamers strongly influences their composition. B) A probabilistic sequence model reveals that the presence of two strict (red) and one relaxed (blue) pentamer provides the best explanation of the data.