Tangier disease

[tanjir′]

Etymology: Tangier Island, Virginia

a rare genetic disorder resulting in a deficiency of high-density lipoproteins, characterized by low blood cholesterol and an abnormal orange or yellow discoloration of the tonsils and pharynx. There also may be enlarged lymph nodes, liver, and spleen; muscle atrophy; and peripheral neuropathy. No specific treatment is known.

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