Abstract

We report herein a novel surfactant-free synthetic approach for hollow silica nanoparticles (HSN) loaded with Au nanocomposites (Au-HSN) to enhance photothermal properties. Transmission electron microscopy and elemental analysis confirmed the uniform HSN of Au nanoparticles. UV-vis spectroscopy and Fourier transform infrared spectroscopy were performed to demonstrate the dopamine (DA)-hyaluronate (HA) coating on Au-HSN. These nanocomposites dramatically increased up to 48 °C within few seconds under near-infrared irradiation. In addition, these Au-HSN/DA-HA nanoparticles showed the excellent endocytosis against cancer cells without any cytotoxicity. Therefore, it could be a powerful nanocarrier for tumor targeting and photothermal therapy applications.

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Acknowledgments: This work was supported by the National Research Foundation (NRF) of Korea grant funded by the Ministry of Science and ICT (MSIT) (Grant number 2015M3A9D7030461, 2016M3A7B4910652). This work was also supported by Basic Science Research Program through the NRF of Korea grant funded by the MSIT (Grant number 2017R1C1B1011677). This research was supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute, funded by the Ministry of Health & Welfare, Republic of Korea (Grant number HI14C3347).