Ingredients are human grade and 100% sourced in the United States. Sold by the case only (12/case). Total number of treats per case =36. (Ingredients - Whole Wheat Flour, Water, Wheat Bran, Canola Oil, Roseen, (a natural preservative), and either Parmesan Cheese; Peanut Butter; Peppermint Oil and Leaves, Parsley Oil and Leaves, Honey; or Carrots, Cranberrries, Flax and Honey.)