Abstract

The UK is currently in the midst of a large outbreak of pertussis, with the highest morbidity and mortality occurring in young
unimmunised infants. This review considers the potential strategies to optimise control of pertussis in infants, including
vaccination of (1) adolescents, (2) close household contacts of newborn infants (cocooning), (3) newborn infants and (4) pregnant
women. The paper discusses the evidence base for each of these strategies and considers the rationale for the recent introduction
of a temporary vaccination programme for pregnant women in the UK in response to the ongoing outbreak.