Macrodantin

OVERDOSE

Occasional incidents of acute overdosage of Macrodantin
have not resulted in any specific symptoms other than vomiting. Induction of
emesis is recommended. There is no specific antidote, but a high fluid intake
should be maintained to promote urinary excretion of the drug. It is
dialyzable.

CONTRAINDICATIONS

Anuria, oliguria, or
significant impairment of renal function (creatinine clearance under 60 mL per
minute or clinically significant elevated serum creatinine) are
contraindications. Treatment of this type of patient carries an increased risk
of toxicity because of impaired excretion of the drug.

Because of the possibility of
hemolytic anemia due to immature erythrocyte enzyme systems(glutathione
instability), the drug is contraindicated in pregnant patients at term (38-42
weeks' gestation), during labor and delivery, or when the onset of labor is
imminent. For the same reason, the drug is contraindicated in neonates under
one month of age.

Macrodantin is contraindicated
in patients with a previous history of cholestatic jaundice/ hepatic
dysfunction associated with nitrofurantoin.

Macrodantin is also
contraindicated in those patients with known hypersensitivity to
nitrofurantoin.

Last reviewed on RxList: 9/20/2013
This monograph has been modified to include the generic and brand name in many instances.