ParticleTrack G600/G600 Ex

Monitor Particle Size and Count in Piloting and Production

ParticleTrack G600 with FBRM technology is a rugged probe-based instrument that is inserted directly into large-scale vessels or pipelines to track changing particle size and count in real time at full process concentrations. Particles, particle structures and droplets are monitored continuously, as process parameters vary, allowing engineers to monitor, troubleshoot and improve processes effectively.

By monitoring particle size and count in real time, at full production scales, engineers can monitor process consistency and identify strategies to make significant process improvements.

Particles can change when sampled and prepared for offline analysis. By tracking changes to size and count, as particles naturally exist in process, engineers obtain process understanding at full production scales, safely and with no time delay – even at extremes of temperature and pressure.

By monitoring particles continuously, as operating conditions vary, it is possible to determine the root cause of poorly performing processes. Operators can identify process upsets quickly and engineers can utilize evidence obtained at full production scale to redesign challenging processes and make improvements.

A flexible mounting system allows probes to be installed in reactors or pipelines using standard flanges, dip pipes and ball valves across a wide range of temperatures and pressures. Optional purged enclosures rated to ATEX and Class I, Div 1 standards ensure instruments can be installed safely in hazardous locations.

Study Particle Size and Count Over TimeScientists insert ParticleTrack probes directly into process streams to monitor particle size and count continuously over time without having to take a sample. This unique information becomes the basis for effective understanding of every process that involves crystals, particles and droplets.

Link the Process to the Particle SystemWith ParticleTrack, scientists routinely determine how process parameters influence particle systems. The impact of process parameters on mechanisms such as growth, agglomeration, breakage and shape change can be identified, allowing processes to be optimized and improved using evidence-based methods.

Create Fit-for-Purpose Particle SystemsScientists use ParticleTrack to determine how particles with the desired size and count can be delivered consistently. By choosing optimized process parameters during development, through scale-up and into production, scientists deliver high quality particle products to the market faster at a lower total cost.

Monitor and Correct Process DeviationsParticleTrack is used to monitor, troubleshoot and improve established processes in production. Difficult processes, where sampling is a challenge, can be monitored safely, ensuring particles with the highest possible quality are produced consistently.

Upgrade to G600/Ex

ParticleTrack G600/G600 Ex Upgrade

Stuck Particle Correction Improves Consistent and Reliable Measurement - ParticleTrack can distinguish between particles stuck on the probe window and those moving in the process. These stuck particles can be removed from the data ensuring a consistent and reliable measurement for more experiments.

Figure 2: Example of legacy Lasentec FBRM instrument failing to observe bimodal distribution of large and small particles, while ParticleTrack displays higher resolution measurement of both particle sizes.

Wider Dynamic Range To Detect Critical Process Events - ParticleTrack measures changes in particle count to accurately eliminate concentration-related artifacts from the data and ensure improved sensitivity to changes in the particle system at higher concentrations. This allows critical process events to be detected that may previously have gone unobserved.

Figure 3: Example of ParticleTrack identifying a secondary nucleation event at the end of a process while at high concentration.

Figure 5: Simultaneous measurement using two different modes using ParticleTrack: Primary is sensitive to the primary particles while Macro is sensitive to overall particle structure.

Two Measurements Acquired Simultaneously To Eliminate Need for Prior System Information or Trial Experimentation - ParticleTrack now collects two datasets simultaneously that are optimized for different types of particle systems. This eliminates the need for any a prior system information or trial experimentation to determine the optimal measurement method.

Improved Instrument to Instrument Repeatability - ParticleTrack technology was developed to ensure different lab and production instruments now measure much more closely, allowing changes in scale of measurement to be decoupled from differences in the probe used to measure them.

"The [ParticleTracK]G400 also captures bimodal character in unweighted chord distributions, producing distinct peaks for aggregates and fines after suboptimal flocculation; such peaks are rarely well resolved in older FBRM".

"…the chord length measurement principle applied with the G400 probe leads to an enhanced sensitivity to species at the lower end of the measurement range relative to previous generation FBRM…"

"The mean square-weighted chord lengths reported from older generation FBRM for flocculated minerals are typically under 400 mm, and yet the naked eye can see much larger aggregates being formed in thickener feedwells. The G400 probe consistently measures larger chord lengths, and this is seen as a significant advantage"

"Process analytical technologies (PATs) have played an important role in process development and optimization throughout the pharmaceutical industry. Recent new PATs, including in-process video microscopy (PVM), a new generation of focused-beam reflectance measurement (FBRM), miniature process IR spectroscopy, and a flow IR sensor, have been evaluated, demonstrated, and utilized in the process development of many drug substances. First, PVM has filled a technical gap by providing the capability to study morphology for particle engineering by visualizing particles in real time without compromising the integrity of sample. Second, the new FBRM G series has closed gaps associated with the old S series with respect to probe fouling, bearing reliability, data analysis, and software integration. Third, a miniaturized process IR analyzer has brought forth the benefits of increased robustness, enhanced performance, improved usability, and ease of use, especially at scale-up".

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