- Compare changes in muscle structure, function (strength + power production and
metabolic function) and mobility.

- Evaluate the patient's adherence to and satisfaction with the RENEW intervention.

OUTLINE: This is a prospective, randomized, controlled, longitudinal study. Patients are
randomized to 1 of 2 intervention arms.

- Arm I: Patients undergo resistance exercise via negative-eccentric work (RENEW), using
a special seated stationary leg exercise machine, 3 times a week for up to 12 weeks.
Exercise exertion and duration is gradually increased weekly for the first 4-5 weeks of
RENEW.

- Arm II: Patients receive standard care. In both arms, fatigue, weakness, physical
activity, functional status, muscle structure and function, and mobility are assessed
at baseline and then at 12 weeks after completion of study intervention. Fatigue and
weakness are also assessed weekly during study intervention. Patients in arm I also
undergo isometric strength assessment weekly during RENEW and assessment of adherence
to and satisfaction with RENEW at 12 weeks after completion of RENEW.

PROJECTED ACCRUAL: A total of 40 patients will be accrued for this study.

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