Number of participants with significant relief of severity and pain by TWSTRS part A and C, respectively, over treatment course

Number of participants with significant relief of severity by objective kinematic reductions in angular deviation and amplitude measures over treatment course

Number of participants with significant improvement in functional disability scores assessed by TWSTRS part B and patient-reported scores pre- and post-BoNT-A parameters determined visually or kinematically.

Number of participants with significant relief of severity by global impression of change scores over treatment course

The primary outcome measure will be the percentage of change in MEP size between, before, and 15-20 min after PAS intervention (MEP post intervention/MEP pre intervention). The amplitude of the MEP in the EMG signal is the outcome measure giving...

The duration of the post-effects will be assessed by the MEP size at the 4 time points.

Performance on the reaching task with a visuomotor conflict.Performance on the Predictive motor timing task.

144

All

18 Years to 65 Years (Adult)

NCT02504905

15016715-N-0167

July 21, 2015

December 31, 2018

December 31, 2018

July 22, 2015

January 4, 2018

National Institutes of Health Clinical Center, 9000 Rockville PikeBethesda, Maryland, United States

The various neurophysiological results including the data from TMS experiment, tremor analysis, threshold of temporal discrimination, ballistic movement and MRI experiment. These results will be compared between HVs and patients group.

78

All

18 Years to 85 Years (Adult, Senior)

NCT03041714

17005317-N-0053

April 7, 2017

October 31, 2019

October 31, 2019

February 3, 2017

February 14, 2018

National Institutes of Health Clinical CenterBethesda, Maryland, United States