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Matrix stiffness modulates oral squamous cell carcinoma cell migration similarly to that of other epithelial carcinomas but by using a different focal-adhesion-mediated mechanism. Read the full Research Article from Marcelo Lamers and team.

Ana Carrera and Richard Anderson discuss the learning points from this workshop, held in October by the Universidad Internacional de Andalucía. Find out about the different mechanisms of phosphoinositide 3-kinase (PI3K) activation in cancer, as well as the events that result in PI3K pathway reactivation after patient treatment with PI3K inhibitors.

Have you seen our First Person interviews with the early-career first authors of our papers? The authors talk about their work in and out of the lab, the journeys that led them to where they are now and the scientists who inspired them along the way. Recently, we caught up with first authors Gayatree Mohapatra, Bibiana Franzen Matte, Susan Lassen and Pierre Vigié.

Journal of Cell Science is pleased to welcome submissions for an upcoming special issue on 'Cell Biology of the Immune System' edited by Ana-Maria Lennon-Duménil. We invite you to showcase your breakthrough research on all aspects of cell biology as it relates to the immune system. The articles within this issue will receive extensive exposure to a broad audience of cell biologists and immunologists. Submission deadline: 30 June 2019.

Journal of Cell Science, Journal of Cell Biology and Molecular Biology of the Cell have announced a new manuscript transfer option, which will be available in the first quarter of 2019. It will empower authors whose manuscripts have been declined to seamlessly transfer their manuscripts and associated peer review reports between the journals.

A self-correcting optical microscope with nanometer-accurate correction means crisp super-super-super-resolution images and ultra-precise distance measurements. The preprint about it from Katharina Gaus and team was of such interest two preLighters decided it deserved highlighting. Read Sam Barnett’s highlight and Lars Hubatsch’s highlight.