The Japanese version of God of War III censored some of the game's more explicit violence and nudity:

• Poseidon's Princess, Aphrodite, and her handmaidens had their breasts covered up.• The graphic wounds that Kratos gives to Hercules' face were removed during his death scene.• When Kratos chops off Hermes' legs, his protruding bones were removed during his death scene.• The scene where Kratos removes Helios' head with his bare hands takes place off-screen.

On the "Remastered" version for the PlayStation 4, Sony censored several trophy names containing sexual innuendos and replaced them less provocative, though still slightly suggestive titles:

• "Are You Horny to Win?" was changed to "Horn of Plenty".• "Hooker" was changed to "Depths Below".

Additionally, the trophy "I didn't do it... But I wish I did!", which is awarded for killing the Poseidon Princess, was removed entirely. This was possibly done to avoid suggesting that beating women should be rewarded, or simply because it came off as tasteless and offensive.

In David Jaffe's version of God of War III, Stheno, the third Gorgon sister, was planned to appear. Again, Kratos would decapitate her and use her head as weapon. However, after Jaffe left the team before the game was developed, the idea was abandoned and her encounter was replaced with Helios.

Director Stig Asmussen revealed in an interview that it was originally intended that, if the player attempts the sex mini-game with Aphrodite a second time, the camera would pan back to the bed to reveal Aphrodite trying to kill Kratos, leading to a QTE where Kratos kills her. This idea was scrapped.