During 1990--2001, the death rate from poisoning* in the United States increased 56%, from 5.0 per 100,000
population in 1990 to 7.8 in 2001 (1). In 2001, of 22,242 poisoning deaths, 14,078 (63%) were unintentional (1). To describe trends in poisoning deaths, state health professionals in 11
states analyzed vital statistics data for 1990--2001. This
report summarizes the results of that analysis, which indicated that increases in state death rates from unintentional and
undetermined poisonings varied, but increased by an average of 145%; a total of 89% of poisonings involved drugs and other biologic substances. State public health professionals can use local, state, and national surveillance data to monitor trends in drug misuse and to
develop effective interventions that can reduce deaths from drug overdoses.

Overall poisoning death rates per 100,000 population and sex-, age-, and intent-specific death rates were calculated.
Trends were examined for the following
categories§: 1) all poisonings, 2) unintentional poisonings, 3) suicides, 4)
homicides, and 5) poisonings of undetermined intent. Poisoning deaths might be classified as of undetermined intent if the medical examiner
or coroner lacked sufficient evidence to determine whether the death was unintentional, suicide, or homicide. Unintentional
and undetermined subcategories were combined for most of the analyses. States with low poisoning death rates because
of undetermined intent had high unintentional poisoning death rates and vice versa because intent coding practices varied
by state.

Of the 11 states, eight¶ had multiple cause-of-death data for 1999 and 2000 to identify the specific substances or classes of substances involved in poisoning deaths in their states. To analyze these data, codes were used from
International Classification of Diseases and Related Health Problems, Tenth Revision
(ICD-10), which was implemented in 1999. ICD-10 contains
specific information about substances and classes of substances in codes T36--T50 (i.e., poisoning by drugs, medications, and
biologic substances). Because more than one T-code was reported for deaths for which multiple substances were implicated, the percentages reported for specific substances represent each substance as a percentage of all identified T-codes.

During 1990--2001, death rates attributed to unintentional and undetermined poisoning increased in all 11 states (Figure), with an average increase of 145% (range: 28%--325%); poisoning homicide rates were stable, and poisoning suicide
rates declined. Nine states (Colorado, Delaware, Florida, Kentucky, New Mexico, North Carolina, Oregon, Washington, and Wisconsin) reported increases in unintentional poisoning deaths; Massachusetts and Utah reported increases in
undetermined poisoning deaths. The largest percentage increases in poisoning deaths were in Florida (325%), Kentucky (252%), and Massachusetts (228%). In Colorado (125%), Massachusetts, and Washington (108%), death rates began to increase
during 1991--1992. The death rates in Florida, Kentucky, North Carolina (80%), and Wisconsin (123%) were stable during 1990--
1996 but increased thereafter. In contrast, the rates in Delaware (186%), New Mexico (105%), Oregon (28%), and
Utah (183%) increased substantially during 1990--1998, but declined thereafter.

During 1990--2001, in all 11 states, the increases in unintentional and undetermined poisoning death rates were greatest for persons aged 45--54 years (average increase: 359%; range: 139%--710%) and persons aged 35--44 years (average
increase: 195%; range: 14%--910%). Among persons aged
>65 years, the rate declined an average of 28%. Sex-specific
unintentional and undetermined poisoning death rates also increased for males (average increase: 126%; range: 11%--339%) and females (average increase: 203%; range: 95%--486%).

Narcotics and psychodysleptics accounted for 51% of all poisoning deaths. In the eight states that examined
T-code frequencies, the substances associated most frequently with unintentional and undetermined poisoning deaths were cocaine (15% of all identified T-codes), alcohol (8%), heroin (7%), antidepressants (5%), benzodiazepines (5%), and methadone (5%). However, the proportion of deaths for which these substances were listed varied substantially by
state (Table). Nonspecific categories, such as "other opioids" (e.g., codeine, morphine, oxycodone, and hydrocodone),
"other synthetic narcotics," "other and unspecified narcotics," and "other and unspecified drugs, medicaments, and
biological substances" accounted for approximately half of all the documented substances associated with unintentional
and undetermined poisoning deaths.

Editorial Note:

The findings in this report indicate that in these 11 states the unintentional and undetermined
poisoning death rate increased during 1990--2001 and that the types of substances associated with these deaths varied by state. Among U.S. adults, drug overdoses are the largest cause of poisoning deaths. In 1992, the total cost of medical spending for all poisoning treatment was approximately $3 billion, an average of $925 per case
(3). Unintentional drug overdose deaths
often are caused by the misuse of multiple drugs, leaving substantial uncertainty about the contribution of each drug to the death. Illicit drugs (e.g., cocaine and heroin) have been
known to cause unintentional poisoning deaths. In certain states, the misuse
of prescription drugs (e.g., pain-management opioids
such as oxycodone HCI with acetaminophen, hydrocodone with acetaminophen, and methadone) has contributed
to the increase in deaths from unintentional poisoning
(4).

The findings in this report are subject to at least four limitations. First, because external cause-of-injury codes used
to classify underlying causes of death often do not provide sufficient information to identify the particular substances to which
a victim was exposed, T-codes were used to identify specific substances that contributed to death
(5). However, approximately half of the substances identified by T-codes on the death certificates were nonspecific, including 27% classified only as "other and unspecified drugs, medicaments and biological substances." This lack of specificity could reflect
limited information provided on the death certificate rather than
deficiency in the T-codes. Second, analyses based on T-codes also
are limited because the underlying causal agent in deaths involving multiple drugs cannot be identified. Third, these data are state specific and might not be representative of the entire United States; death certificate reporting practices might differ both within and among states. Finally, the poisoning death trends presented in this report should be interpreted with
caution because the analysis spans two revisions of the ICD (ICD-9 and ICD-10), and the two classification systems do not always produce comparable figures (6).

Key risk factors for drug overdose deaths include multidrug misuse and recent abstinence from substance abuse
(7,8). Interventions directed at providing assistance to overdose
patients could include using naloxone, teaching rescue
breathing, and encouraging use of 911 to obtain emergency medical services. However, preventing these deaths is a complex challenge that might require a combination of psychological,
behavioral, educational, and medical interventions.

States in this study reported different mortality profiles for different substances, suggesting that local surveillance data
are needed to help guide prevention efforts. Understanding distribution patterns of medications and illicit drugs in each state, the circumstances of their use (e.g., while alone or with others who could intervene), and the factors that contribute
to increased use (e.g., chronic pain, substance abuse, or mental illness) also could help in developing effective public health
strategies. Public health professionals should engage the help of others (e.g., substance abuse and mental health workers, law enforcement officials, medical examiners, and physicians) to reduce use of illicit drugs and misuse of prescription drugs, particularly opioids prescribed for pain management
(9,10).

References

CDC. Web-based Injury Statistics Query and Reporting System (WISQARS). U.S. Department of Health and Human Services, CDC,
National Center for Injury Prevention and Control, 2003. Available at
http://www.cdc.gov/ncipc/wisqars/default.htm.

Gossop M, Stewart D, Marsden J. A prospective study of mortality among drug misusers during a 4-year period after seeking treatment.
Addiction 2002;97:39--47.

Sanford CP. Deaths from unintentional drug overdoses in North Carolina, 1997--2001: a DHHS investigation into unintentional
poisoning-related deaths. Raleigh, North Carolina: North Carolina
Department of Health and Human Services, 2002. Available at
http://www.dhhs.state.nc.us.

* Poisoning refers to the damaging physiologic effects of ingestion, inhalation, or other exposure to a range of pharmaceuticals, illicit drugs, and chemicals,
including pesticides, heavy metals, gases/vapors, and common household substances, such as bleach and ammonia.

 Colorado, Delaware, Florida, Kentucky, Massachusetts, New Mexico, North Carolina, Oregon, Utah, Washington, and Wisconsin. These 11 states participated in the 1999 State Injury Indicators Report
(2), a collaborative effort of 26 state health departments, CDC, the Council of State and Territorial Epidemiologists,
and the State and Territorial Injury Prevention Directors Association, which noted an increase in poisoning deaths.

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