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About Me

Hi! My name is Qadoshyah and I'm the oldest of 11 kids. I live on a ranch in the beautiful country of Northeastern Oklahoma with my family. We are a large household with so many kids that we have various projects going on: We raise goats, pigs, sheep, and rabbits (I raise the rabbits - cute little mini lops) on our 44 acre ranch. Our ranch is also home to bullmastiffs, chickens, guinea hens, ducks, llamas, a donkey, a bottle calf, and several ranch dogs and livestock guardian dogs. The youngest two kids are boy/girl twins born in Feb. '05. The boy happens to have Down syndrome. He is such a blessing to our family :)! Our whole family is also gluten-free, which adds another interesting aspect to our large, active family. We also cook dairy-free & corn-free due to allergies a few kids have. Some of the family is also on the GAPS diet to restore gut health.

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The writers of this blog research and attempt to give what they believe is the most accurate and up-to-date information. Nonetheless, the information on this blog is simply opinions and does not in any way constitute professional legal or medical advice. Also, references or links to external, or third party websites, are provided solely for visitors' convenience and are not controlled nor monitered by us. Links taken to other sites are done so at your own risk.

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Thursday, June 20, 2013

Remember the study that prompted my big post on EGCG a few months back? The one that showed EGCG can actually create Mitochondrial Biogenesis in individuals with Down syndrome? Yeah, that was huge news!

A critical role for mitochondrial dysfunction has been
proposed in the pathogenesis of Down's syndrome (DS), a human
multifactorial disorder caused by trisomy of chromosome 21, associated
with mental retardation and early neurodegeneration. Previous studies
from our group demonstrated in DS cells a decreased capacity of the
mitochondrial ATP production system and overproduction of reactive
oxygen species (ROS) in mitochondria. In this study we have tested the
potential of epigallocatechin-3-gallate (EGCG) – a natural polyphenol
component of green tea – to counteract the mitochondrial energy deficit
found in DS cells. We found that EGCG, incubated with cultured
lymphoblasts and fibroblasts from DS subjects, rescued mitochondrial
complex I and ATP synthase catalytic activities, restored oxidative
phosphorylation efficiency and counteracted oxidative stress. These
effects were associated with EGCG-induced promotion of PKA activity,
related to increased cellular levels of cAMP and PKA-dependent
phosphorylation of the NDUFS4 subunit of complex I. In addition, EGCG
strongly promoted mitochondrial biogenesis in DS cells, as associated
with increase in Sirt1-dependent PGC-1α deacetylation, NRF-1 and T-FAM
protein levels and mitochondrial DNA content.

In
conclusion, this study shows that EGCG is a promoting effector of
oxidative phosphorylation and mitochondrial biogenesis in DS cells,
acting through modulation of the cAMP/PKA- and sirtuin-dependent
pathways. EGCG treatment promises thus to be a therapeutic approach to
counteract mitochondrial energy deficit and oxidative stress in DS.

Well, we have the full text in PDF format of that study, which is always a helpful resource to have. You can download the PDF here.