The Federal Ministry of Science, Research and Economics has granted a federal project to establish software and database infrastructure for life science. CUBE will coordinate this project, which has a total volume of 660k EUR from 2017 to 2020. The main aim is to install and maintain a rich and up-to-date repository of bioinformatics software and life science databases on national, regional and local high-performance computing clusters. Life scientists will be able to use these compute resources easier and more efficiently. The project will also establish a national helpdesk for bioinformatics and life science data. The project is part of the "Hochschulraumstrukturmittel" initiative and involves three universities: University of Vienna, Medical University of Vienna and University of Innsbruck.