"That is like so ridiculous and 10 years ago I would have been alarmed because my dad hadn’t had a heart attack yet. But now it’s like his thing. My mom’s had breast cancer, she’s had lung cancer. So now if they call in with, 'Oh, we have skin cancer.' It’s like 'OK, that’s fine.' Versus it’s not as alarming as the first time."

Such are the joys of dealing with aging parents, she says, and it's one of the universal topics she's found in her nearly three decades in comedy that bring people together.

"Most everybody has parents and if you do have parents, we’re all going to watch our parents get older, if we’re lucky. And it’s really just the same kind of funny (mess) for everybody. They can be a pain in the (butt) at times, and they can be difficult at times, but it’s also pretty funny at times."

Volunteer Alex Rush and producer Mia Swier lends support to Show Up 2018, encouraging young people to register to vote at Elsie Fest 2018, in Central Park on Sunday, Oct. 8, 2018. Courtesy of Show Up 2018

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Finding the universally funny can be challenging in a political climate that often has people at each other's throats, but Madigan says the subjects that do transcend are out there and often deal with human nature.

Kathleen Madigan will perform at the Paramount Theatre in Asbury Park.(Photo11: Courtesy of Luzena Adams)

"That's the kind of cool thing. Starting out in the Midwest (she's originally from St. Louis), I was intimidated by the bigger cities, but then when you get there, people are just people. That’s the great news. Everybody’s kind of doing the same thing. We work, unless you’re independently wealthy or something. People get married. They have kids. They have boyfriends, girlfriends. We’re all just experience kind of the same stuff. Nobody is really that different."

She says her tour stop will be "exactly what you would expect. I always try to do some new stuff, some old stuff, some stuff from the newest Netflix special. It's just a fun night out, is how I like to put it." (The tour name refers to "two of my favorite things I talk a lot about in my act. A goose honk to other geese. You see it and you go, 'Oh, I like boxed wine. I like to talk to about Bigfoot.' ")

That's not to say she will avoid politics altogether.

Kathleen Madigan returns to the Meyer Theatre on Saturday night. Yes, the election is sure to come up, but the comedian is keeping that material to a minimum to give fans a break.(Photo11: Bryan Steffy/Getty Images)

"I’m more furious right now, not about Donald and not about the left — I’m just really more furious about the age of the people in charge of us. I’m really happy 85-year-olds are alive and I’m really happy that my parents are 78. They’re out golfing — good for them. But when we’re talking about governing a nation, no, I don’t think you should be 85.

"(With Mark) Zuckerberg and Congress, nobody asking the questions knew what to ask because everybody is too old. It was just a wasted opportunity to fix something because the people who should be fixing it don’t even know what the problem is. I do a bunch of jokes about the old people asking him questions. Then I do jokes about my parents. I know what the 78-year-olds are doing all day. My parents are go-getters, but they’re always covered in Band-Aids. I don’t know what’s up with that."

Madigan's newest comedy special "Bothering Jesus" is streaming on Netflix, and her comedy album of the same name has become the highest-selling debut of a comedy album since 2014.

"You can actually see progress in real time," she says of her work with cystic fibrosis organizations. "One kid we've known since he was 6, now he's about 17. They have to wear these jackets to clear their lungs, like three or four times a day, and he’s down to every other day. Not that one should need to see progress to continue doing work, but it does make it a lot more hopeful."

For tickets to Madigan's shows at the Paramount Theatre or NJPAC, visit Ticketmaster.com.