A Significant Financial Interest is one or more of the following interests of a Covered Individual or member of his or her Family that reasonably appears to be related to the Covered Individual's Institutional Responsibilities:

Remuneration received from a Business in the twelve-month period immediately prior to the disclosure or expected from a Business in the twelve-month period immediately following the disclosure. For purposes of this definition, remuneration includes salary and any payment for services not otherwise identified as salary (e.g., consulting fees, honoraria, paid authorship);

An equity interest held in a Business at the time of disclosure. For purposes of this definition, equity interest includes any stock, stock option, or other ownership interest; or

Intellectual property rights (e.g., patents, copyrights), royalties from such rights, and agreements to share in royalties related to such rights.

For Investigators who are engaged in Sponsored Research funded by PHS, Significant Financial Interest includes, in addition to the interests described in (a)-(c) above, reimbursed travel or sponsored travel that is related to an Investigator's Institutional Responsibilities; sponsored travel means travel that is paid on behalf of the Investigator and not reimbursed to the Investigator (so that the exact monetary amount may not be readily determined).

The term Significant Financial Interest does not include: (i) salary, royalties, or other remuneration paid by TSRI to the Covered Individual if the Covered
Individual is currently employed or otherwise appointed by TSRI, including intellectual property rights assigned to TSRI and agreements to share in royalties
related to such rights; (ii) income from investment vehicles, such as mutual funds and retirement accounts, as long as the Covered Individual does not directly
control the investment decision made in these vehicles; (iii) income from seminars, lectures, or teaching engagements sponsored by a Federal, state, or local
government agency, an institution of higher education, an academic teaching hospital, a medical center, or a research institution that is affiliated with an
institution of higher education; and (iv) income from service on advisory panels for a Federal, state, or local government agency, an institution of higher
education, an academic teaching hospital, a medical center, or a research institution that is affiliated with an institution of higher education.

2Family: Includes a spouse and dependent persons as defined by the Internal Revenue Code.

3Business: Any entity, either for-profit or not-for-profit, that is not TSRI or a governmental entity.

4Institutional Responsibilities: Professional responsibilities on behalf of TSRI, including, but not limited to purchasing, teaching, research, administration,
professional practice, institutional committee membership, and service on panels such as Institutional Review Boards or Data and Safety Monitoring Boards.

5Scientific Trainee: Any graduate student or professional scientific trainee, including but not limited to members of the Scientific Staff working under the direction
of a member of the Faculty. Included in this category are Research Associates and Senior Research Associates.

6Other Conflicts of Commitment: A situation where a commitment to Outside Professional Activities of a Covered Individual adversely affects his or her capacity
to meet his or her responsibilities at TSRI. A Conflict of Commitment is perceptible because of a reduction of the Covered Individual's time and intellectual energies
devoted to TSRI activities.

7Executive Position: Any person in a position having authority to direct or control a material segment of the operation or management of a Business, including
serving on its Board of Directors/Trustees.

8Sponsored or Reimbursed Travel: Reimbursed or sponsored travel that is related to an Investigator's Institutional Responsibilities is required to be disclosed,
unless the travel is reimbursed or sponsored by a Federal, state, or local government agency, an institution of higher education, an academic teaching hospital, a
medical center, or a research institute that is affiliated with an institution of higher education. The disclosure must include, at a minimum, the purpose of the trip, the
identity of the sponsor/organization, the destination, and the duration. Sponsored travel means travel that is paid on behalf of the Investigator and not reimbursed to
the Investigator (so that the exact monetary amount may not be readily determined). Investigator travel meeting these criteria must be disclosed at
https://travel.scripps.edu or by adding entries to Part III of this diclosure.

9Investigator: An Investigator means the principal investigator, co-principal investigator(s), co-investigator(s), project director(s) at all levels, all personnel named in
the application as Senior/Key personnel, and any other person, regardless of title, who is responsible for the design, conduct, or reporting of research funded by the
PHS and other Federal agencies, or proposed for such funding.

10Outside Professional Activities: An activity outside of TSRI engaged in by a Covered Individual in a professional capacity. Outside Professional Activities
include, for example, consulting services, teaching, service on public or private boards and advisory committees, and service to governmental, nonprofit and
professional organizations. Outside Professional Activities may be compensated or uncompensated.