Meanwhile, Sen. Lisa Murkowski, an Alaska Republican who is not pro-life, says she, too, will vote no on Kagan on the Senate floor.

"As Ms. Kagan acknowledges, the cases that come before the Supreme Court are difficult in nature and not always answered by precedent. Over the past week Ms. Kagan has given the American people hardly any idea about how she will approach these difficult cases," the senator said.

"Her responses to many of the questions posed by my colleagues on the Judiciary Committee were clever and graceful but not terribly revealing and in many cases evasive," Murkowski added.

The Alaska senator also expressed hesitation because Kagan shows little judicial or legal experience preparing her for serving on the nation's highest court.

“I did not support Ms. Kagan’s nomination to be Solicitor General of the United States because I did not think she had the requisite experience for the job. It is not essential that a Supreme Court nominee have experience as a judge but those who lacked that experience had substantial experience in the practice of law," she said.

She concluded, " Kagan has spent the bulk of her career as an academic, a university administrator and policy advisor. For the reasons I have cited here, I plan to oppose her nomination when it comes before the Senate."

McConnell's and Murkowski's opposition come on the heels of pro-life Sen. Orrin Hatch becoming the first member of the Senate Judiciary Committee to announce his opposition to Kagan.