geneRxCluster: gRx Differential Clustering

Version 1.14.0

Detect Differential Clustering of Genomic Sites such as
gene therapy integrations. The package provides some functions
for exploring genomic insertion sites originating from two
different sources. Possibly, the two sources are two different
gene therapy vectors. Vectors are preferred that target
sensitive regions less frequently, motivating the search for
localized clusters of insertions and comparison of the clusters
formed by integration of different vectors. Scan statistics
allow the discovery of spatial differences in clustering and
calculation of False Discovery Rates (FDRs) providing
statistical methods for comparing retroviral vectors. A scan
statistic for comparing two vectors using multiple window
widths to detect clustering differentials and compute FDRs is
implemented here.