Supplementary Table S3: Ranking of top bio functions following IPA analysis. For each cell system, a cut-off was chosen such that comparable amounts of molecules were analyzed (in MG63/M8, a lower number of probe sets -521- were found to be significantly regulated, corresponding to a lower number -364- of recognized molecules). The top-5 bio functions, divided into the subcategories “diseases and disorders”, “molecular and cellular function” and “physiological system development and function” were compared among cell systems with the order displayed. Functions that were most commonly observed are shown first for each subcategory.

Supplementary Table S4: GO terms commonly up- or down-regulated in metastasis in the SAOS/LM5 and Dunn/LM8 cell line systems.