Welcome to Medical News Today

Healthline Media, Inc. would like to process and share personal data (e.g., mobile ad id) and data about your use of our site (e.g., content interests) with our third party partners (see a current list) using cookies and similar automatic collection tools in order to a) personalize content and/or offers on our site or other sites, b) communicate with you upon request, and/or c) for additional reasons upon notice and, when applicable, with your consent.

Healthline Media, Inc. is based in and operates this site from the United States. Any data you provide will be primarily stored and processed in the United States, pursuant to the laws of the United States, which may provide lesser privacy protections than European Economic Area countries.

By clicking “accept” below, you acknowledge and grant your consent for these activities unless and until you withdraw your consent using our rights request form. Learn more in our Privacy Policy.

Please accept our privacy terms

We use cookies and similar technologies to improve your browsing experience, personalize content and offers, show targeted ads, analyze traffic, and better understand you. We may share your information with third-party partners for marketing purposes. To learn more and make choices about data use, visit our Advertising Policy and Privacy Policy. By clicking “Accept and Continue” below, (1) you consent to these activities unless and until you withdraw your consent using our rights request form, and (2) you consent to allow your data to be transferred, processed, and stored in the United States.

Get the MNT newsletter

Email an article

You have chosen to share the following article:

How elderberries can help you fight the flu

To proceed, simply complete the form below, and a link to the article will be sent by email on your behalf.Note: Please don't include any URLs in your comments, as they will be removed upon submission.

We do not store details you enter into this form. Please see our privacy policy for more information.

Childhood eczema, asthma may be relieved with new treatment

New research, published in the Journal of Investigative Dermatology, presents a new approach for treating atopic eczema and preventing the worsening of the asthma that sometimes ensues in children.

The study findings may soon lead to new therapies for childhood eczema.

Atopic dermatitis, also known as eczema, affects between 15 and 20 percent of children and between 1 and 3 percent of adults worldwide.

In the United States, between 10 and 20 percent of children aged 10 and below have atopic eczema, and a total of 28 million Americans are affected by the condition.

The condition is more prevalent among children, and some affected infants go on to develop allergic rhinitis or asthma later in life. This is known as an "atopic march" – a phenomenon whose causes, mechanisms, as well as ways to prevent it have puzzled researchers for years.

Now, a new study brings us closer to understanding the roots of atopic march, as scientists at VIB Ghent University in Flanders, Belgium, searched for a cure for both asthma and atopic dermatitis.

The team was led by Dr. Julie Deckers, Prof. Karolien De Bosscher, and Prof. Hamida Hammad – all from Ghent University's Center for Inflammation Research.

Studying atopic march in mice

Dr. Deckers and colleagues created a mouse model of the atopic march, in which the rodents were exposed repeatedly to house dust mites through the skin, as well as in the lungs. House dust mites are known to trigger both eczema and asthma.

The researchers wanted to see if "relief of skin inflammation by glucocorticoids and PPAR [gamma] agonists might influence the subsequent development of asthma."

Glucocorticoids and PPAR gamma agonists are two anti-inflammatory compounds, which the researchers administered topically to the mice.

Firstly, their study revealed more insights into the complex development of the atopic march. "As predicted," the lead researcher explains, "our test showed that house dust mite-induced skin inflammation leads to aggravated levels of allergic airway inflammation."

"Yet, to our surprise," Dr. Deckers continues, "this response significantly differs from the reaction to direct exposure of house dust mites in the lungs without prior skin inflammation. These results have given us a deeper understanding of the complexity of the atopic march," the researcher adds.

A 'potent remedy' for childhood eczema

As for the effect of the combined anti-inflammatory compounds on both conditions, this was also quite successful.

"Cutaneous combined activation of [glucocorticoids and PPAR gamma agonists] reduced skin inflammation to a higher extent compared to single activation," write the authors.

This was done by counteracting the response of the so-called T helper 17 cells – a type of immune cell.

"However, the treatment did significantly reduce the severity of the asthma by counteracting one aspect of the specific immune response in the lungs. In this way, the therapy represents a potent remedy against allergic skin inflammation and the aggravation of atopic march."

Dr. Julie Deckers

In future, the scientists are looking to bring their findings to human clinical trials and simultaneously work on developing new therapies that could effectively stop the development of the atopic march.

Neither atopic dermatitis nor asthma have a known cure, so the need for prevention strategies for these conditions remains dire.

2019 Healthline Media UK Ltd. All rights reserved. MNT is the registered trade mark of Healthline Media. Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare professional.