Preparation and Storage

This product is an active protein and may elicit a biological response in vivo, handle with caution.

Reconstitution

It is recommended that 0.5 ml of sterile phosphate-buffered saline be added to the vial.
Following reconstitution short-term storage at 4°C is recommended, and longer-term storage of aliquots at -18 to -20°C. Repeated freeze thawing is not recommended.

General Info

Alternative names

Interleukin 2 receptor alpha chain

CD25

CD25 antigen

IDDM10

IL 2 receptor alpha subunit

IL-2 receptor subunit alpha

IL-2-RA

IL-2R subunit alpha

IL2 RA

IL2-RA

IL2R

IL2R, alpha chain

IL2RA

IL2RA_HUMAN

IMD41

Interleukin 2 receptor

Interleukin 2 receptor alpha

Interleukin-2 receptor subunit alpha

p55

t-cell growth factor receptor

TAC

TAC antigen

TCGFR

see all

Function

Receptor for interleukin-2.

Involvement in disease

Genetic variations in IL2RA are associated with susceptibility to diabetes mellitus insulin-dependent type 10 (IDDM10) [MIM:601942]. A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical fetaures are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.

A sample of ab84071 without carrier protein was reduced and
alkylated and focused on a 3-10 IPG strip then run on a 4-20% Tris-HCl 2D gel.
40µg protein loaded per lane; Deep Purple™ stained. Spot train indicates presence of multiple isoforms.
Spots within the spot train were cut from the gel and identified as IL2 Receptor alpha (Fc Chimera) by protein mass fingerprinting.

Densitometry of protein isoforms visualised by 2-DE.
The densitometry scan demonstrates the purified human cell expressed protein exists in multiple isoforms, which differ according to their level of post-translational
modification.
The triangle indicates the theoretical MW and pI of the protein.

References

ab84071
has not yet been referenced specifically in any publications.

Publishing research using ab84071? Please let us know so that we can cite the reference in this datasheet.