The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component

of tight junction strands. Loss of function mutations result in neonatal ichthyosis-sclerosing cholangitis

syndrome. (provided by RefSeq, Jul 2008)

GeneCards Summary for CLDN1 Gene:

CLDN1 (claudin 1) is a protein-coding gene. Diseases associated with CLDN1 include sclerosing cholangitis, and cholangitis. GO annotations related to this gene include structural molecule activity and identical protein binding. An important paralog of this gene is CLDN4.