Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

Other / NIH

Observational Model: Cohort

Time Perspective: Prospective

It is anticipated that endometrial expression of implantation markers will be upregulated by metformin treatment compared to baseline and improved parameters will be identified with longer duration of metformin exposure. endometrium biopsy

blood draw (20mL)

A combination of quantitative real time PCR, immunohistochemistry, and Western Blot techniques will be utilized for studying endometrial markers of receptivity in the endometrial tissue

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

Other / NIH

Intervention Model: Single Group Assignment

Masking: None (Open Label)

Primary Purpose: Treatment

Generate Preliminary Data on the Range of Outcome Measures at Baseline and After 6 Months of Fiber Supplementation in Terms of: Ovulation Rates, Insulin Sensitivity, Concentrations of Circulating Androgens and Satiety.