Using the S100B Protein for Emergency Headache Management Care (S100)

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The purpose of this study is to determine the negative predictive value of protein S100B that could exclude subarachnoid and intracranial haemorrhage for patient that present severe headache within the last 3 hours.

Condition or disease

Headache, MigraineHemorrhage

Detailed Description:

This study will be proposed to every patient that correspond to eligibility criteria, such as presenting a severe headache (Visual Analog Scale ≥ 6/10) within 3 hours before arriving to the emergency.

After signing the informed consent, a blood sample will be taken in order to dosage S100B protein of each patient, and then they will have a brain scan.

The trial ends after the brain scan for each patient. Results of brain scans will be compared with results of S100B dosage.

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Ages Eligible for Study:

18 Years and older (Adult, Older Adult)

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

No

Sampling Method:

Non-Probability Sample

Study Population

The population will be recruited in the emergency unit

Criteria

Inclusion Criteria:

Male or female over 18 years-old

Patient presenting at the Emergency Service a non-traumatic severe headache lasting for less than 3 hours. The severity is defined as a VAS ≥ 6/10

Blood sample can be taken within 1 hour following the emergency admission

VAS > 6 or Glasgow < 8

Signed and dated informed consent by patient, or trusted person, or family