LaMichael James and A.J. Jenkins, the 49ers' first two 2012 draft picks, are active. It's the first time James has been in uniform this season, while Jenkins has dressed twice but has yet to play a snap.

Manningham is dealing with a shoulder injury. However, Jacobs, who appears to be healthy, recently went on an Instagram rant in which he expressed his unhappiness with the 49ers, calling this season "by far the worst year I ever had."