IBSchek™ (Blood Test)

IBSchek™

The Functional Gut Clinic is delighted to be the first centre in the UK to offer IBSchek*– a new blood test for IBS. A large proportion of IBS patients develop symptoms after a previous gastrointestinal infection (post infectious IBS). IBSchek is a new blood test has been developed to look for biomarkers that identify whether a previous gut infection has caused a reaction which could affect gut function.

IBSchek detects 2 biomarkers in the blood (anti-CdtB‡ and anti-vinculin) that are predictive of a previous gastroenteritis event. In a comprehensive clinical trial in more than 2,500 patients conducted in 180 centres around the U.S. IBSchek was found to be more commonly positive in IBS compared to patients with Crohn’s disease, ulcerative colitis, and coeliac disease. IBSchek therefore provides a positive diagnosis of an organic cause for IBS in a proportion of IBS patients.

Once a positive diagnosis of IBS is made, The Functional Gut Clinic can help to understand what effect IBS is having on your gut function and importantly what are the main factors contributing to your symptoms using targeted breath tests (Hydrogen and Methane breath test). We are also the UK’s leading centre offering the Wireless Motility Capsule (SmartPill) to assess whole gut motility and transit as well as profiling the pH in the colon which is a biomarker of bacterial fermentation (Caecal pH in IBS paper).

Your Doctor will then have all the information they need to provide targeted therapy or utilise non-pharmacological therapy provided by the Functional Gut Clinic’s Dietetics and Bowel re-training therapy specialist. This provides a unique IBS pathway for patients starting with a diagnosis, evaluation of the causes of your symptoms, therapy guided by scientific evidence and best practice, follow-up and support and re-testing to check for treatment efficacy.

Information Sheets

Irritable bowel syndrome (IBS) is an extremely common condition. Between 1.9 and 3.6 million patients consult a healthcare professional for IBS each year in the UK (1). The total population prevalence is much higher as most IBS sufferers are non-consulters due to the perceived lack of effective treatments.

The main symptoms are abdominal pain / cramping, bloating, distension, nausea, flatulence, altered and/or unpredictable bowel habit, urgency to defecate which can lead to episodes of incontinence, fatigue, loss of appetite and anxiety.

Whilst IBS is not considered a life threatening condition it is a life altering condition which can affect sufferers severely in their day to day activities.

There may be many potential causes of IBS including changes in the location and composition of gut bacteria, increased bowel sensitivity, an inability to properly absorb bile acids in the small bowel, intolerances to foods, stress and previous psychological trauma. Identifying the most probable cause can help to target treatments which may include treating a combination of the above factors within the same patient.

For most people, IBS is a diagnosis of exclusion given when other conditions such as inflammatory bowel disease have been ruled out. The diagnosis is based on symptoms (as defined by the Rome III criteria) and the exclusion of ‘red flag’ symptoms such as rapid weight loss, bleeding from the rectum etc. Until recently, there has not been an objective test which provides a positive discriminatory diagnosis of IBS.

Once you have been given a diagnosis of IBS there is unfortunately little consensus on what further diagnostic testing could be needed, what treatment strategies should be employed and what positive treatment outcomes should look like to the patient and physician.

This can lead to frustration for IBS patients who are given a ‘functional’ diagnosis which is supposed to give reassurance but still leaves many questions to be answered. At the Functional Gut Clinic we work closely with your Doctor to form a ‘joined up pathway’ to make sure your diagnosis and treatment is optimised.

Recent work has shown that the composition and location of gut bacteria can cause symptoms which are experienced by IBS patients. For example, if you have bacteria in the small bowel (SIBO – small intestinal bacterial overgrowth), they will begin to ferment foods before your body has had chance to digest and absorb the nutrients.

This produces gas and acids (short chain fatty acids) within the small bowel which can lead to changes in sensitivity and motility. As the small bowel is not designed to cope with this fermentation it can lead to symptoms of nausea, bloating, pain, indigestion, heartburn, belching, fatigue and headache. As similar effects will be felt almost regardless of whatever foods you eat (healthy or not!) this can be very confusing for patients.

If the problem is with the composition of gut bacteria within the colon, this means that normal fermentation can become excessive or produce undesirable by-products which affect factors such as gut motility and sensation as well as make you feel generally unwell. It has recently been conceived that suffering from a previous gastrointestinal infection can change the gut microbiota and make people more susceptible to SIBO.

Whilst each of these treatment approaches have shown efficacy, it is clear that further refinement of the IBS diagnostic algorithm is required to better target therapies in order to overcome the inherent heterogeneity (overlap of causes) within the IBS population which is how our tests help.

These can include a full range of hydrogen and methane breath testing to see how bacteria and absorption of different carbohydrates may be contributing to your symptoms. We see this test as a provocation test which marries together physiological information about your gut with the symptoms you feel during the test to fully understand the clinical relevance of our observations. This helps you and your Doctor to devise a targeted plan to treat the different factors that might be contributing to your symptoms.

We work closely with your Doctor to make sure everyone fully understands the implications of your test results. In some cases you may be referred on to our dietetics or bowel re-training specialists for non-pharmacological treatment. We sometimes repeat tests to see if your treatment has been effective.