Radiofrequency ablation (RFA) is a relatively new, percutaneous minimally-invasive, endoscopic or intraoperative ablation method which destroys tumours by local application of heat. We were not able to identify studies of RFA for the treatment of colorectal cancer which met the inclusion criteria of this systematic review. In terms of RFA of pancreatic cancer, we identified two prospective case-series including 82 patients. According to GRADE, the quality of evidence is very low due to the uncontrolled study design of the included case-series. Overall, the available evidence is insufficient to assess the efficacy and safety of RFA for the treatment of pancreatic cancer. Furthermore, there is no evidence concerning RFA for the treatment of colorectal cancer.