*Please note that AMN082 dihydrochloride (ab120011) is only soluble to 5 mM in water.

Receptor

Description.

mGlu1,5

(S)-3,5-DHPG:

Selective group I mGlu agonist.

Suggested Solvent: Water

mGlu5

(R,S)-CHPG sodium salt:

Water soluble form of (R,S)-CHPG (ab120039), a selective mGlu5 agonist.

Suggested Solvent: Water

mGlu2,3

LY379268:

Highly potent and systemically active mGlu2 and mGlu3 agonist. EC50 values are 2.69 and 4.48 nM for hmGlu2 and hmGlu3, respectively and displays > 80-fold selectivity over group I and group III receptors. Effective in several animal models of stroke, epilepsy, drug abuse, schizophrenia, and pain.

Suggested Solvent: Water

mGlu4,6,7,8 (group III)

L-AP4:

Selective group III mGlu receptor agonist.

Suggested Solvent: Water

mGlu4

VU0155041 sodium salt:

Water soluble, positive allosteric selective modulator at mGluR4 (EC50 values are 798 nM and 693 nM at human and rat mGluR4 receptors, respectively). It has advantages over PHCCC (ab120043) as it is water soluble and more potent. Active in behavioural models of Parkinsons Disease.