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Hundreds of millions of dollars are chasing the question of how to order food from a smartphone. Success will depend on which service can maximize revenue and profits through a combination of charging restaurants and diners.

Despite recent declines in high-flying growth stocks, bankers remain uniformly optimistic that the IPO window will be open for many quarters to come. But one important bellwether—the biotech sector—suggests that investor appetite for the riskiest startup companies may indeed be starting to wane. ...