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Friday, May 18, 2012

Overview of Testosterone Clinical Trials

Testosterone and itseffectsonsexualfunction

1. A
long–term prospective study of the physiologic and behavioraleffects of hormone replacement in untreated hypogonadal men –A.S. Burris et al.Journal of Andrology

1992; 13(4):297–304.

Men
withlowlevels oftestosterone
whohad not yet been treated with supplemental hormone showed significantlyhigher
levels of depression, anger, fatigue and confusion than did
men with acceptabletestosterone levels. Duringtestosterone replacement therapy,scores
improved. Also during treatment, thesemen reported increasedsexual interestandgreater numbers of spontaneous erections. (Design ofStudy: Hypogonadal men before and during
testosterone treatment compared to untreatednormal
men and untreated
infertile men; noplacebo treated controls.)

Journal ofClinicalEndocrinology
and Metabolism1979; 48(6):955–958.

The study found
that the effect of testosterone
replacement onsexualactivity in
hypogonadalmenis rapid, reliable, and notdue
to placeboeffect.To maintaintestosterone
levels and adequatesexual
function, testosterone replacement should be administered
on anongoing basis.(Design of Study:
Hypogonadal
men during double blind, randomized,
cross-over treatmentwithsub-replacement and replacement doses of testosterone; noplacebo
treated controls.)

1. A
long–term prospective study of the physiologic and behavioraleffects of hormone replacement in untreated hypogonadal men –A.S. Burris et al.Journal of Andrology

1992; 13(4):297–304.

Men
withlowlevels oftestosterone
whohad not yet been treated with supplemental hormone showed significantlyhigher
levels of depression, anger, fatigue, and confusion than did
men with acceptable testosterone levels.During testosterone replacement
therapy, scoresfor the
previously untreated
hypogonadalmen improved indicativeof less
depression, anger,fatigue, and confusion.
(Design
ofStudy: Hypogonadal men before and during
testosterone treatment compared to untreatednormal
men and untreated
infertile men; noplacebo treated controls.)

8. Effectof
testosterone treatment onbody composition andmuscle strength in men over 65 years of age –P.J. Snyder, et al.Journal of Clinical Endocrinology
and Metabolism 1999;84:2647–2653.

Researchers examined changes in body composition
and muscle strength in108 men over 65 years of
agewho received testosterone
for 36 months. The
study found that increasing testosterone concentrations
inmenover65years of age to the midnormalrange decreasedfatmass and increased
lean mass,but did
not necessarily increasemusclestrength. (Design of Study: Randomized, placebo
controlledstudy of men
over age 65 treatedwithtestosterone
patches and placebo patches.)

A total of70 HIV–positive menwithlowtestosterone
levels
completed a six-week trial
of biweeklytestosterone or placebo treatments.Seventyfour
percentofmen who received
testosterone reportedmuchor
very much improved libido, comparedto 19% ofplacebo-treatedmen. Of menwith fatigue at baseline,