Changes in the mitochondrial permeability transition pore in aging and age-associated diseases

Giuseppe ParadiesDepartment of Biosciences Biotechnologies and Biopharmaceutical, University of Bari and Institute of Biomembranes and Bioenergetics, National Research Council of Italy, Bari, ItalyMech Ageing Dev 134:1-9. 2013

The effect of reactive oxygen species generated from the mitochondrial electron transport chain on the cytochrome c oxidase activity and on the cardiolipin content in bovine heart submitochondrial particles

G ParadiesDepartment of Biochemistry and Molecular Biology and CNR Unit for the Study of Mitochondria and Bioenergetics, University of Bari, ItalyFEBS Lett 466:323-6. 2000

..This article is part of a Special Issue entitled: Dynamic and ultrastructure of bioenergetic membranes and their components. ..

Changes in the mitochondrial permeability transition pore in aging and age-associated diseases

Giuseppe ParadiesDepartment of Biosciences Biotechnologies and Biopharmaceutical, University of Bari and Institute of Biomembranes and Bioenergetics, National Research Council of Italy, Bari, ItalyMech Ageing Dev 134:1-9. 2013

..This article examines data relevant to this issue. The important role of a principal lipidic counter-partner of the MPTP, cardiolipin, will also be discussed...

..In this review, we focus on the role played by oxidative stress and cardiolipin in mitochondrial bioenergetic alterations associated with brain aging...

The effect of reactive oxygen species generated from the mitochondrial electron transport chain on the cytochrome c oxidase activity and on the cardiolipin content in bovine heart submitochondrial particles

G ParadiesDepartment of Biochemistry and Molecular Biology and CNR Unit for the Study of Mitochondria and Bioenergetics, University of Bari, ItalyFEBS Lett 466:323-6. 2000

..These results may prove useful in probing molecular mechanism of ROS-induced peroxidative damage to mitochondria which have been proposed to contribute to aging, ischemia/reperfusion and chronic degenerative diseases...

Lipid peroxidation and alterations to oxidative metabolism in mitochondria isolated from rat heart subjected to ischemia and reperfusion

G ParadiesDepartment of Biochemistry and Molecular Biology and C N R Unit for the Study of Mitochondria and Bioenergetics, University of Bari, ItalyFree Radic Biol Med 27:42-50. 1999

..These findings may provide an explanation for some of the factors that lead to myocardial reperfusion injury...

The effect of aging and acetyl-L-carnitine on the pyruvate transport and oxidation in rat heart mitochondria

..The thyroid hormone induced change in the activity of the phosphate carrier appears to be due to a more favorable lipid microenvironment (cardiolipin content) surrounding the carrier molecule in the mitochondrial membrane...

Giuseppe PetrosilloDepartment of Biochemistry and Molecular Biology and CNR Institute of Biomembranes and Bioenergetics, University of Bari, Bari, ItalyBiochim Biophys Acta 1767:1260-7. 2007

..It is concluded that CD diet causes mitochondrial complex I dysfunction which can be attributed to ROS-induced cardiolipin oxidation. These findings provide new insights into the alterations underlying mitochondrial dysfunction in NAFLD...

..This synergistic effect of Ca2+ and CLOOH on MPT induction and cytochrome c release in mitochondria might have important implications in the apoptotic process as well as in several pathophysiological situations...

Effect of aging on the activity of the phosphate carrier and on the lipid composition in rat liver mitochondria

..The results suggest that CD-induced dysfunction in brain mitochondria may be responsible for impairment in cognition and underline that, similar to the liver, the brain also needs an adequate choline supply for its normal functioning...