"It's Okay (One Blood)" is a song by American rapper and West Coast hip hop artist The Game featuring vocals from reggae singer Junior Reid, from his second studio album Doctor's Advocate. Released as the album's lead single on July 24, 2006, the song was written by The Game himself and Junior Reid, and it was produced by D-Roc, and Reefa. The Game himself revealed that the song would be released on July 31, 2006, but actually was released on July 24, 2006. The song was originally to be released on July 4, 2006 but got pushed back by The Game. Jimmy Rosemond, head of Czar Entertainment and The Game's manager, explained how "One Blood" would receive positive radio airplay and prove the talent that The Game had.[1] A supposed original version of the song was released in late January 2011. The song was produced by Dr. Dre.[2]

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When news of The Game's first single was announced by Rosemond, it was revealed simply as "One Blood" and is the name it commonly goes by (also, the words "Blood" and "One Blood" are repeated throughout the song). The song samples Junior Reid's "One Blood" and features Junior Reid himself. According to Reefa, the producer of the song, "One Blood" was mixed by Rap-A-Lot/Tha Dogg Pound affiliated producer Mike Dean for Dean's List Productions. Several lines in the song stirred controversy as to who the lines were aimed at: "You 38 and you still rappin, ugh", was aimed at Jay-Z, as well as a diss at snap music; "Turn on the TV and all you see is the A/You niggaz better make up a dance and try to get radio play/Keep on snapping your fingers, I ain't going away." After he clearly made a diss to Atlanta, GA, The Game later changed his mind about who he was referring to in a radio interview with HOT 107.9 and said the following:

Banks and Buck have albums coming out near to mines, you know what I'm saying? So I'm telling them if they trying to sell some records this time, then they better fly to the "A" and get to, you know, doing something, you know? Y'all make up a dance to the song, you know what I'm saying? It's all good. And you know, just to say it again man, I'M NOT DISSING THE "A"![3]

The Game made a music video for the song, which debuted on BET on August 22, 2006.[4] The video features revised lyrics in order to accommodate television decency standards. There are appearances in the video by Juice, Ya Boy, Nu Jerzey Devil, DJ Skee, Andrew Reid, Wada Blood, Young JR, Mickey Jarrett Jr and Tyrese.