Family whose members (JAK1-3, Tyk2) are critical for cytokine signaling

Associated with intracytoplasmic portion of cytokine receptors, which serves as docking site for STAT monomers; activated JAK activates and phosphorylates the STAT monomers, which then dissociate, dimerize and migrate to nuclear, where they interact with specific DNA binding elements and activate transcription of cyclin D1, bcl-Xl, bax, bcl2, c-myc, c-Jun, c-kit, and IL-10

This website is intended for pathologists and laboratory personnel, who understand that medical information is imperfect and must be interpreted using reasonable medical judgment. We are unable to respond to patient inquiries.