The northern lands suffered less than the south, but Cardolan still suffered greatly, and all of its surviving Dúnedain were lost to the Plague. The sickness lost its power as it passed northwards, and by the time it reached northern Arthedain it had become far less dangerous.

By the end of III 1637 the Plague had passed, but the great losses it had caused left many lands of Middle-earth all but abandoned. At this time Gondor's guard on Mordor ceased, and the lands between Gondor and Arnor were left unpeopled (including the region of Calenardhon where Rohan would be founded long afterwards).