Abstract The cyanobacterial symbionts of the marine sponge Chondrilla australiensis (Demospongiae) were examined using fluorescent microscopy and Transmission Electron Microscopy. Unicellular cyanobacteria with ultrastructure resembling Aphanocapsa feldmannii occur in the cortex and bacterial symbionts are located throughout the mesohyl. In C. australiensis, the developing eggs are distributed throughout the mesohyl and are surrounded by nurse cells attached to them by thin filaments. The nurse cells form cytoplasmic bridges with the eggs, apparently releasing their contents into the egg cytoplasm. The presence of cyanobacterial and bacterial symbionts inside developing eggs and nurse cells in 25% of female Chondrilla australiensiswas established using Transmission Electron Microscopy, suggesting that these symbionts are sometimes passed on to the next generation of sponges via the eggs.

I think it would be great if things could be made clearer, so that everyone could easily see just what is involved.

Hi Hartuk,

This process of encouraging healing by first intention is important in any treatment of infection of the skin or subcutaneous tissue.

The ways in which you are dealing with the layers of hardened and dead skin is obviously effective, although time intensive and laborious.

There is also the fact that some degree of problems still exist, such as the itching, also something 'gel-like' around the hair roots next to the scalp, and the fact that you extracted something like a blue fiber not so long ago from your scalp.

Is that all correct?

Is there still evidence of hardened and dead patches of skin?

The reason why I say all this is because you live in a big city.

Some big cities in the UK have premises entitled 'Skin', where you can actually pay to see a dermatologist.

They have specialised lasers on the premises.

If you do go, (and anyone can walk in off the street), do not entertain the notion of letting a therapist or even nurse loose on you with a laser.

Just politely tell the nurse you wish to have a consultation with the consultant dermatologist, thank you very much.

This will be the more expensive option, and you might be better phoning first to book a definite appointment.

It is up to this skilled professional, (i.e. the consultant dermatologist), but you could request that any hardened layers of skin be treated by the appropriate laser, is this is felt by the consultant to be clinically feasible.

After all, some people routinely pay the doctor to do this for the hard skin on their feet within these premises, and walk out with baby soft soles instead of the hooves that they suffered from previously.

You could first of all check with the expert specialist doctor overseeing your care and treatment that such a step would be conducive to your healing and recovery.

Do you have any other problems still outstanding with this apparent syndrome?

I do appreciate your advice and input, but you live in a world wearing rose tinted spectacles, that I can not locate, and I live in the same city as you.
In addition, you are being patronising, relating to me as if a fool.

Where are these dermatologists you talk of ? There is not a dermatologist specialising in fungal infections of the skin in the UK. There is not a even specialist department at any London hospital.
I have seen dermatologists, NHS and Private. They can not even see the problem. I had a skin scraping at St Marys. Nothing. All they mentioned was Staph Aureus and the diagnosis was Excema. End of story. It remains this way.
I had an Ear Infection that would not clear over the past 2/3 months. I was told that if the product that was prescribed did not clear it, then I should not bother her again. In her words "use vinegar".
It did not clear.

Peroxide finally did the job.

I am doing this to myself.

Am I making myself clear ?

I have asked to be referred to the hospital for tropical diseases, on the basis that I have a very unusual Dermatophyte infection. I am prepared to pay. My GP still will not refer me. She will not prescribe Itraconazole.
Diflucan costs £12.50 per 150 mg, over the counter. So now I have a £25 a day Diflucan habit as well. I buy generic Itraconazole online.
Any other problems...why yes..how about my eyes.

I can see where the pathogen enters my right eye and
I have been to Moorfields emergency.
Diagnosed with Blepharitis, Keratitis and at the time droopy eyelid syndrome.
Caused by my sleeping with my eyes open or some caustic substance that I must have administered in error.

Eye specialists at Moorfields can not see it.

I went to quite a well known Dermatologist on Cavendish Sq.
Guess what ...a prescription for 10 days Doxy and laser treatment to remove some hair.
At £90 per half hour session how much to clear my body as the reality of this disease is ...head to foot.

The Itraconazole has, in fact, stopped the itching.

Also, this "Skin" is not any skin I am familiar with. This callous material is part of the protective biofim containing Chitin and Cellulose, is it not ?
Removing it is very difficult indeed. The images of the blue /red fibres I posted are from the junk on my scalp.....

Do you think that a cosmetic dermatologist on any high street in any place on this planet would direct a laser at my head looking the way it does ? I actually laughed outloud at this proposal.

You have seen the back of my head.
Imagine the front.
How dare you be so patronising. I looked like a leper.
Now I have my eyebows back I might just step ouside my front door.

I have got to the point where any contact with these pathetic self appointed experts is not worth the angst and resultant stress that it involves.

Please do not get angry, I am very sorry if you think that I am patronising, but I will tell you this. I certainly do not think that you are a fool. Oh no, very far from it, very, very, very far from that.

I do not wear rose tinted glasses. I do think, (if a consultant dermatologist thought it proper to remove the hard 'skin' in your case), he would see the ridges that I can see, and think.

I do not mean going to a hospital, I mean that particular shop. All I meant was that he or she would have to look very carefully. If Cliff Mickelson can say, to the 'expert' eye that the callus is simply not the same as skin, why can't a dr?

Eventually, (maybe sooner than you think), they will take on board everything, e.g. if Cliff can convince via the media.

Please remember, (there is a name for this phenomenon), people often genuinely cannot see what their brain is telling them can't be possible. Once the dermatologists start to be convinced, they will look properly at the callus, test it, (I do not know what exactly it is composed of. It may be partly the person's skin, but it certainly is not, to my mind, 'normal'. Not once you know how to look, and what to look for). Ironically, I think it is probably much more difficult for a professional dr. to see it. Cliff said, no-one alive has ever seen it before, (until this disease emerged). That statement is so mind boggling it is almost impossible to take in. Wait until he, Geema and South take the media by storm with this, proving just how weird the callus is by their controlled experimentation, (burning it etc.). The point is, these experiments are replicable, and will be done again and again by scientists world wide. The, things will erupt! This 'skin' is growing out of people's bodies! (As though you did not know!)

I am truly sorry if I offended you. Be aware of one thing, though, and take this to your heart. I am not the empty headed London bimbo that I may appear. If I ask you something, or say something to you, it is because I have a reason. That reason is in your best interests, (insofar as I know anything at all). Think about it. Do you really think that I would spend all that time and energy going on about silly women who cannot pick up a skin file?

Yes, I did want to know about your eyes. The blepharitis diagnosis in this condition is, to my mind, not on. Once they see how weird the 'callus' is, the next step will be to prove that other organs and tissues within the body can be affected. Blepharitis is, as I am sure they told you, 'incurable'. Occasionally the odd paper emerges, viz. consider parasites as a (treatable) cause, i.e. demodex mites. We'll see about all this. You have, it would seem, perhaps been treated very very badly. I want to help. I've to be careful how I ask, and what I say. I admire you more than you know. Don't worry about the outburst to me, (maybe you wouldn't anyway, I'm not presuming anything), because you have suffered quite enough and taken it on the chin.

Generic fluconazole is cheaper than Diflucan, especially in some small chemists.

I am really sorry again, Hartuk, and I truly take my hat off to you because of what has been done (or not done). I think things are on the move, though, thank God!

Sorry.
My response was a knee jerk reaction to the news that terramycin has not been available for humans in the UK since 2003.
So, I am angry and frustrated at the realisation that I will have to visit the vet again and pretend I am a dog. I hesitate to say cat.
As a horse, I was a fool and the vet was not fooled at all.

Apologies again, and I appreciate all your help, maybe more than you know.

I do think the reason Ms. Savely's article written in June (with Dr. Stricker+) might have not been released (only the title is out there for view) or maybe they pulled it.

Anyway, I have a feeling they may have changed the name from what I predicted as well was the title of Ms. Savely's article, to something else. I say this simply because, (and don't get me wrong....I did not want to have that disease any way!) I have also watched the emerging diseases come/go and change on different list: i.e., google....the CDC....Pub Med, etc. I have watched one in particular that said there was a case in 1970 with a man and his mule to one in 1953 in France but yet when you open that up it changed to 1983 in america. Point is....I'm thinking they will change.

I think Skytroll mentioned Glanders this morning yet I do not recall what her post stated about it. anyway, this disease and it's bacillus I have been watching.....(the last article I read about it said it was only found in tropical areas) said it was similar to or could mimic glanders-
something to that effect.

This new one I'm thinking they should go for is a soil bacterium
called Pseudomonas pseudomallei. It causes what they call Melioidosis check out the title of my last search of this:
_________________________________________________
tITLE:
Melioidosis. Forgotten, but not gone!

Melioidosis, infection by the soil bacterium Pseudomonas pseudomallei, has the potential for prolonged latency with recrudescence into an acute, often fulminating, and fatal infection. Although the organism is never found in North America, infection is endemic in areas of southeast Asia, and populations of service personnel exposed during the Vietnam war and southeast Asian immigrants are at risk of severe recrudescent disease. Diagnosis, however, has been missed or delayed because of lack of familiarity with this disease. We present a case of recrudescent melioidosis that illustrates the difficulties encountered in diagnosis and treatment. This case involves a 76-year-old Vietnam veteran who presented with melioidosis of the bone 18 years after exposure to the organism and 10 years after a missed diagnosis of latent pulmonary disease. This case illustrates the protean nature of latent infection and the difficulty of selecting successful antibiotic therapy.
******************************************************
This is quite interesting to watch.....although that above article states that it does not occur in the soils of North america.....as well as quite a few more articles state this too and also state that there were no cases -except in 1970???(I think, it keeps changing) but now, the cdc has a page on it.

That's the one I'm thinking they will say our infection is....or is caused from when, and if ,they name it.

Sorry if my description of it up above sounded wordy or changing....I'm telling you guys, this whole disease is apparently crossing a wide array of other diseases...(my case exactly that it is still in the making! ) I've seen it say glanders, septicemia to tulerema to the schistomiacis to of course....the immunocompromised. An Example: This is my whole google page of it: check out the different, vast titles. Especially the 1st and second one on the top of this google page. I believe it contradicts itself-one stating it originates in the soil from North America and the very next one says it does not live/grow in North America. You be the judge:

here is another one to watch out for....and if they say our disease is Meliodosis, this will go perfectly under that !

*this is called:Capnocytophaga

****ABSTRACT: A case of fatal sepsis due to Capnocytophaga species is described. Capnatophaga canimorsus and C. cynodegmi can cause localized wound infections and/or systemic infections in people who have been bitten, licked, scratched, or merely exposed to cats or dogs, especially splenectomized individuals. A thorough social, medical, and surgical history, the clinical presentation, and cultures are important in making the diagnosis of Capnocytophaga infections. It is important that the forensic pathologist be aware of this zoonotic disease.
***************************************
I did do some more searches on on this soil bacterium, pseudomona pseudomallei, and it is also called Whitmores Diseasefrom what they are calling....the Whitmores bacillus.

The really confusing part to me has been that the above bacteria pseudomona pseudomallei, has also been used with the Burkholderia pseudomallei in that broad name of a disease....>MELIODOSIS.

What???? Fungal Bioterrorism?????
LEADING FUNGAL INFECTION EXPERTS to discuss disease challenges
at upcoming mycology medical conference. The threat of fungal
agents being misused for bioterrorism will gain the most public
attention over the next year, compared with other fungal disease issues,
according to one-quarter of fungal (medical mycology) specialists
surveyed in an exclusive report. Surprisingly, however, none of those
surveyed consider such a bioterrorist threat to be the most significant
challenge facing the area of fungal disease.
Hmmmm, interesting .

The recently sequenced Rickettsia felis genome revealed an unexpected plasmid carrying several genes usually associated with DNA transfer, suggesting that ancestral rickettsiae might have been endowed with a conjugation apparatus. Here we present the genome sequence of Rickettsia bellii, the earliest diverging species of known rickettsiae. The 1,552,076 base pair–long chromosome does not exhibit the colinearity observed between other rickettsia genomes, and encodes a complete set of putative conjugal DNA transfer genes most similar to homologues found in Protochlamydia amoebophila UWE25, an obligate symbiont of amoebae. The genome exhibits many other genes highly similar to homologues in intracellular bacteria of amoebae. We sought and observed sex pili-like cell surface appendages for R. bellii. We also found that R. bellii very efficiently multiplies in the nucleus of eukaryotic cells and survives in the phagocytic amoeba, Acanthamoeba polyphaga. These results suggest that amoeba-like ancestral protozoa could have served as a genetic “melting pot” where the ancestors of rickettsiae and other bacteria promiscuously exchanged genes, eventually leading to their adaptation to the intracellular lifestyle within eukaryotic cells
http://genetics.plosjournals.org/perlse ... en.0020076

I'm just going to make one last comment. When I was (past tense) looking at the HIV/AIDS viruses last week, I came upon some new ones that is how and why i wanted to discuss them here. It seems as if only Sky and myself ventured out to do so. But if you all do not want us to discusss it, we wont. Yet, here is somethings (other things) that went with it that is why I was wanting you guys to open your minds......

With out mentioning the HIV, here is the two components that I was reading about that went with it....... One is the Simian 40 virus >whch I believe was in this cloning process and the other was the : Creutzfeldt-Jakob disease

that last one scares me more than anything. I think another name we might be more familiar with is Mad Cow disease. Well, this is why I wanted to talk about it last week, but I will tell you something else....
TamTam mentioned the year 1917 today, did he not??? Maybe you guys should look at the Creutzfeldt-Jakob disease in that genre>1917!!!!!