Archives for October 2015

Glutamine powder by DFH: 3/4 of a teaspoon = 3g, so 1/6 of a teaspoon = 500mg

If you’ve been following me for awhile, worked with me, read my book The Antianxiety Food Solution, or listened in on The Anxiety Summit, you’ll be aware that I use glutamine with clients to help with blood sugar control while we’re figuring out diet/breakfast/adrenal health and the carbohydrate/sugar cravings associated with low blood sugar. Opened on to the tongue or taken in powder form glutamine is super-effective for stopping that intense desire for something sweet if it’s related to low blood sugar.

I started the glutamine trial low and slow. I have been taking 500mg three times a day AM AFT & BED for the past 4 days. I am celiac and have irritable bowel as well. The 2-3x a day diarrhea I have been experiencing has completely stopped! Blood sugar feels stable – not hungry and not craving. Psychologically, I’m feeling more resilient i.e., calmer and more positive on a daily basis. I am surprised that glutamine has helped so much 🙂 My gut is healing and my mental health has improved markedly through this trial.

She confirmed that adding the glutamine was the only change she made. She is already gluten-free and her diet doesn’t include any grains, legumes or lactose etc. She also avoids other foods to which she has had reactions.

I was so thrilled with these fabulous results and this was my feedback:

These are fabulous results – so happy for you! If you feel you could get added benefits i.e. if these symptoms (low blood sugar, hunger, craving, resilience) are not all 0s (with 10 being the worst on a scale of 1 to 10) then I’d consider bumping up the glutamine to 1000mg 3 x day to see if you get added benefits. If you don’t see added benefits then you can go back down.

It’s very common to get good results like this so I’d like to share another example. I met Nicole at the NTA conference and she shared how she suffers from low blood sugar issues:

I get irritable, I get shaky and I get to the point that if I don’t get food NOW I think I’m going to hurt something!

She did a trial of 500mg glutamine and in under 5 minutes she went from that frantic feeling to a very calm feeling:

I’m ok. I feel happy, I feel calm, I feel I can make it longer without needing food right away. I’m impressed at how well that worked for me.

glutamine has been reported to enhance intestinal and whole-body growth, to promote enterocyte proliferation and survival, and to regulate intestinal barrier function in injury, infection, weaning stress, and other catabolic conditions

glutamine stimulates growth of the small intestinal mucosa in young animals and also enhances ion transport by the gut in neonates and adults

as a functional amino acid with multiple key physiological roles, glutamine holds great promise in protecting the gut from atrophy and injury under various stress conditions in mammals and other animals.

Oral supplementation with [glutamine], for a short time, altered the composition of the gut microbiota in overweight and obese humans reducing the Firmicutes to Bacteroidetes ratio, which resembled weight loss programs already seen in the literature.

Lower intakes of nutrient-dense foods and higher intakes of unhealthy foods are each independently associated with smaller left hippocampal volume. To our knowledge, this is the first human study to demonstrate associations between diet and hippocampal volume concordant with data previously observed in animal models.

Study participants were Australian adults aged 60-64. The results of the study, show that an unhealthy “Western” diet is associated with a smaller left hippocampus and a healthier “prudent”, nutrient-dense diet is associated with a larger left hippocampus.

characterized by the consumption of fresh vegetables, salad, fruit and grilled fish

This study has importance for cognition and mental health, both depression and very possibly anxiety too:

extensive evidence from animal studies points to the importance of the hippocampus in the association between diet and mental and cognitive health

The hippocampus is a brain structure associated with both learning and memory, as well as mood regulation, and is specifically implicated in depression

The study does group high sugar and high saturated fat together, and unfortunately the healthy diet excludes good quality red meat which is surprising considering previous research and conversations with Dr. Jacka about the benefits of good quality red meat and mental health:

In our study, out of every single dietary food grouping that I looked at including vegetables, fruits, salads, beans, etc the strongest correlate of mental health was red meat intake [grass-fed red meat of course]

Consistently, women who have less than the recommended intake of red meat seem to be in an increased risk for common mental disorders [like anxiety and depression] and bipolar disorder.

It will be wonderful to see follow-up research looking at the effect of quality grass-fed red meat on hippocampus size.

Drew Ramsey, MD, an assistant clinical professor of psychiatry at Columbia University College of Physicians and Surgeons in New York City, described the study as “exciting” in an interview on Medscape Medical News:

It’s the first time that a dietary pattern has been linked to specific changes in the brain. We’ve known for a long time that there’s a correlation between dietary pattern and the risk of a number of brain illnesses, like depression and dementia, and the mechanism behind this, we believe, involves neuroplastic processes of how food affects brain growth. This is the first study that’s really shown that quite conclusively.

This webinar is being hosted by my friend and colleague, Magdalena Wszelaki, founder of Hormones Balance.

Here is how she introduces herself:

I’m a certified nutrition coach, speaker, educator and chef with a long history of my own hormonal challenges which resulted from a highly stressful life in advertising – starting from Graves’ and Hashimoto’s Disease (autoimmune conditions causing thyroid failure) to adrenal fatigue and estrogen dominance. Today I’m in full remission, live a symptoms-free, awesome life and I want to show you how to achieve the same. Food was instrumental in my own recovery. My mission is to help you figure out what food your body craves or rejects as there is no one diet or protocol that works for all. Knowing your body will be your fast-track to balanced hormones and to the person you want to be.

You may remember our great interviews on last season of The Anxiety Summit! She was a hit, is a wealth of knowledge and very hands-on when it comes to food for hormone balancing! I really love what she offers (and her cute accent)!

Here is a great image from Cooking for Balance showing you just how much caffeine is in your drink!

Magdalena shares many ways on how caffeine impacts our hormones. Here are just two of them (and both can make anxiety worse):

Exhausts the adrenals

Coffee stimulates the adrenals to release more cortisol, our stress hormone; this is partly why we experience a wonderful but temporary and unsustainable burst of energy.

What many of us don’t realize is that our tired adrenals are often the cause of unexplained weight gain, sleeping problems, feeling emotionally fragile, depression, anxiety and fatigue. Drinking coffee while experiencing adrenal fatigue is only adding fuel to the fire.

Worsens PMS and lumpy breasts

It’s well-established that coffee contributes to estrogen dominance, which can mean one of two things: we either have too much estrogen in relation to progesterone, or we have an imbalance in the estrogen metabolites (some are protective and some are dangerous).

PMS, lumpy breasts, heavy periods, cellulite and even breast cancer (which is an estrogenic cancer) can be symptoms of estrogen dominance.

Here is a great question that came in from one of the attendees of the live Amazing Aminos for Anxiety program that I hosted earlier this year. This attendee is asking when to use a combination of tryptophan and 5-HTP for anxiety and sleep, and concerns about high cortisol when wanting to use 5-HTP:

The book says “for symptoms that occur earlier in the day, 50-150 mg of 5-HTP on waking and midmorning” but it also cautions about taking 5-HTP if one has severe insomnia (which I do) as it can raise cortisol. Is it okay to take tryptophan upon waking and mid-morning? I’m assuming the reason for holding off until late afternoon is to avoid daytime drowsiness, but am wondering if this is where the tyrosine may come in? (At the end of the program)

I started getting good results at 500 mg tryptophan. Sometimes I needed more so I doubled the dose to 1000 mg. Sometimes I got better results than others. It’s possible I may need to take more than that – the book says to take up to 1500 mg. Is consistency key (as opposed to PRN/as needed) when taking tryptophan, in the same way that one has to build up a blood level of serotonin when taking an SSRI? I also wanted to mention that prior to coming off my SSRI, my mood was fine

She is referring to my book The Antianxiety Food Solution and she had been taking these amino acids before starting the group program with me. Her goals were to address her insomnia, the anxiety and the depression. The tryptophan she had been taking was not the Lidtke tryptophan, which is the brand I recommend.

You can listen to the 4 minute snippet of this question and my answer here:

And a friendly reminder for you …. we are offering $100 off each of the 3 options of The Amazing Aminos for Anxiety homestudy programs. This offer expires today, Monday October 19th at 9pm PST midnight EST (previous emails said 9pm EST – sorry about that)

This is a powerful home study program that results in you feeling

less stressed and overwhelmed, and happier

more energetic and focused

sleeping through the night

and no longer suffering from emotional eating/stress eating!

I walk you through, one week at a time, how to use five of the top individual amino acid supplements (tryptophan/5-HTP, GABA, glutamine, DPA/Endorphigen and tyrosine) to help you eliminate anxiety, social anxiety and panic attacks. We also cover pyroluria, other key nutrients, diet and lifestyle changes.

There are 3 program options available:

Basic: Homestudy if you’re a DIY person

OR

Plus: Homestudy + 2 Q and A Live with Trudy (if you need some guidance and will have questions you can opt for this one)

OR

Premium: Homestudy + 4 Q and A live with Trudy (if you need some guidance and will have questions) + private Facebook group for group discussions and interactions.

All 3 options include access to Questions and Answers from the previous program so you get to learn from others. Options 2 and 3 include the LIVE Question and Answer sessions i.e. you can ask your own questions (option 3 also includes the facebook support).

For #3 Premium program, we will also be closing the cart and not taking new registrations until January next year

5-Hydroxytryptophan (5-HTP) is an aromatic amino acid naturally produced by the body from the essential amino acid L-tryptophan. Produced commercially by extraction from the seeds of the African plant, Griffonia simplicifolia, 5-HTP has been used clinically for over 30 years. The clinical efficacy of 5-HTP is due to its ability to increase production of serotonin in the brain.

In the central nervous system (CNS), serotonin has been implicated in regulation of sleep, depression, anxiety, aggression, appetite, temperature, sexual behavior, and pain sensation.

Therapeutic administration of 5-HTP has been shown to be effective in treating a wide variety of conditions, including depression, fibromyalgia, binge eating associated with obesity, chronic headaches, and insomnia.

I advise my clients to take all the amino acids between meals and away from protein containing food so they are no getting competition from other amino acids, thereby affecting absorption of the targeted individual amino acid they are taking. I typically make the same recommendation for taking 5-HTP however I simply do this to make things less complicated. In actual fact, 5-HTP can be taken with meals:

Intestinal absorption of 5-HTP does not require the presence of a transport molecule, and is not affected by the presence of other amino acids; therefore it may be taken with meals without reducing its effectiveness.

The recommended starting dose for 5-HTP is 50mg two or three times a day and it is well absorbed:

Initial dosage for 5-HTP is usually 50 mg three times per day with meals. If the clinical response is inadequate after two weeks, dosage may be increased to 100 mg three times per day. For insomnia, the dosage is usually 100-300 mg before bedtime. Because some patients may experience mild nausea when initiating treatment with 5-HTP, it is advisable to begin with 50 mg doses and titrate upwards.

5-HTP is well absorbed from an oral dose, with about 70 percent ending up in the bloodstream. It easily crosses the blood-brain barrier and effectively increases central nervous system synthesis of serotonin.

It’s well recognized that 5-HTP (and tryptophan) can impact both serotonin and melatonin levels but is often less recognized that other neurotransmitters can be increased too:

Other neurotransmitters and CNS chemicals, such as melatonin, dopamine, norepinephrine, and beta-endorphin have also been shown to increase following oral administration of 5-HTP.

The author does seem to favor 5-HTP over tryptophan but I have found that many of my clients do better on one versus the other. I typically start my clients on tryptophan unless they have benefited from 5-HTP in the past. I would also recommend tryptophan at night if someone is wired-tired and adrenal testing shows high cortisol levels as 5-HTP can raise cortisol levels.

It really all comes down to our own biochemical individuality. I recommend doing a trial to see which amino acid is going to work for your symptoms. I write about this in this blog: How to do an amino acid trial for anxiety

Low serotonin MAY be a factor in anxiety and/or depression (and research shows this to be a fact). Anxiety and/or depression could have one of many possible causes – low serotonin, blood sugar instability, poor diet, not eating enough protein, sugar, caffeine, gluten, low dopamine (for depression), pyroluria, inflammation etc.

If low serotonin is a factor then 5-HTP (or tryptophan) is one way to start to raise serotonin levels so you can feel calm, confident, happy, pain-free again, as well as sleep through the night and end the afternoon and evening cravings.

Have you found 5-HTP to be effective? Please share how much you take/took and when, and how it made you feel. Did you also try tryptophan and do you prefer 5-HTP? We’d love to hear in the comments below.

Have you got questions? Feel free to ask in the comments below.

If this information sounds intriguing and you’d like practical help to figure out if you could possibly benefit from 5-HTP or one of the other amino acids, I invite you to join us in one of The Amazing Aminos for Anxiety homestudy group programs. This homestudy group program will provide guidance with using each of the targeted individual amino acids.

The best way to figure out if you have a particular brain chemical imbalance and if you’ll benefit from a certain amino acid, is to do a trial. This is something I do with all my clients with anxiety, when we’re working one-one-one and with those in group programs, and it works really well.

Because the effects of amino acids can be felt within a few minutes to a few days, it’s easy to confirm whether you do in fact have a deficiency in a certain area and whether you’ll benefit from supplementing with the associated amino acid.

I also have my clients review the Amino Acids Precautions and we figure out which amino acids they can and can’t use

I have them do a trial of the amino acid that resonates the most with them. For example if they have really bad obsessive thoughts, anxiety in the head, negative self-talk we’ll start with trying to address low serotonin with tryptophan or 5-HTP. If they resonate more with physical tension and overwhelm, we’ll start with trying to address low GABA with GABA.

We trial one amino acid at a time and use them opened onto the tongue or chewed (and held there for 1 to 2 minutes) for getting immediate feedback.

I have my client rate themselves before the trial and then afterwards (10 is worst), looking for benefits and how many notches they improved. This helps us figure out how much to start with.

If they see a small improvement (like 1 or 2 notches) we may start with the lowest dose and give them a range to try over the next week (for example 1-2 x 500mg tryptophan or 1-2 x 125 mg GABA)

During the trial and over the next week we also look for possible negative effects, such as a headache or feeling light-headed. If the adverse effects of supplemental amino acids are uncomfortable, taking 1,000 mg of vitamin C is an effective short-term antidote.

If someone is very sensitive to small amount of supplements, we may have them do a trial with a dab or two rather than a whole capsule and start really low during the next week.

We typically allow a week to see how the selected amino acid is working and adjust up or down during that week until we find the optimal amount.

You are able to figure out what your starting dose of the amino should be and are able to adjust upwards accordingly

You get more in tune with your symptoms and how certain amino acids affect you

You can use the results (provided you log them – this is something I recommend and encourage) if you ever need a tune up in the future

Which amino acids have you found to be effective? Did you do a trial to figure out which one to try and how did that work for you? We’d love to hear in the comments below?

Have you got questions about doing a trial? Feel free to ask in the comments below.

If this information is useful but also sounds a little overwhelming, check out the The Amazing Aminos for Anxiety homestudy program. This homestudy group program provides guidance with using each of the targeted individual amino acids and how to do a trial.