“The African clawed frog Xenopus laevis is one of the world’s most widely used model organisms – yet existing anatomical descriptions are nearly a century old, incomplete and use outdated nomenclature. Moreover, Xenopus exhibits many unusual skeletal and soft-tissue characters compared to well-described “typical” frogs such as Rana. We used diceCT to create a 3D digital dissection of Xenopus, including the skeleton, muscles, nervous, respiratory digestive and reproductive systems. The method was particularly useful in this instance as it preserves 3D topological relationships and permitted dissection of a very small, fragile specimen.”