Kip Wells (1-2) allowed three runs on seven hits and three walks with three strikeouts over six-plus innings to absorb the loss.

Chase Headley, Will Venable and Yasmani Grandal each had a hit for the Padres, who saw their six-game winning streak come to an end.

Cincinnati struck first in their first at-bat when Cozart led off the game by crushing a fastball from Wells over the wall in left field to give the Reds a lead which they would not relinquish.

The Padres put together a threat in the fifth. Following a Grandal strike out, Yonder Alonso walked and Venable shot a hard grounder through the left side of the infield for a base hit, putting two runners on with one out.

Arroyo battled back, though, striking out Everth Cabrera before getting Wells to fly out weakly, keeping the Padres off the board.

"Tonight was another good pitching performance by Arroyo," Padres manager Bud Black said. "It was a variation of speeds on his breaking balls and the fastball just got us. We couldn't barrel anything up."

The Reds added to their lead in the seventh when Frazier started the inning with a walk and Hanigan got a hanging breaking ball from Wells and deposited it into the first row beyond the wall in left field to make it a 3-0 game.

Jay Bruce began the Cincinnati eighth with a double and, after a Ryan Ludwick ground out, Frazier ripped a breaking ball from Padres reliever Miles Mikolas in nearly the same spot as Hanigan's blast to extend the lead to 5-0.

Cincinnati capped the scoring with consecutive doubles by Drew Stubbs and Votto in the ninth.