In 2009, Berrington and actress Shirley Henderson were the stars of the popular ITV drama May Contain Nuts she played Ffion, a snobbish suburban mother. Berrington also played Nicola, a nurse in the BBC Two comedy, Psychoville. She also appeared as Food Technology teacher Ruby Fry in the BBC TV series Waterloo Road from 2009 to 2011, departing after two series on the show. She played "Auntie" in "The Doctor's Wife", an episode in series 6 of Doctor Who. In 1997, she appeared in a TV Licence advert. From 2012–2013 she portrayed Paula Kosh in the Sky comedy series Stella, in 2015 she returned. In 2012 she was in an episode of New Tricks, playing a murderer called Grace.

In 2011, Berrington starred in the BBC Christmas show, Lapland as Paula, a role which she reprised in the six part spin-off series Being Eileen, which aired from February 2013.[2][3] She appeared onstage in the 2013 play The Low Road. She appeared on Series 2 Episode 4 of Cuckoo as Sandra in August 2014.