Thrombolytics

Thrombolytics, unlike anticoagulants and antiplatelets, will actually dissolve a clot. We are going to break them down into two categories: Direct acting and indirect acting.

Direct Acting

Urokinase (Abbokinase) – inj – tends to be utilized when we need to open a clotted central line catheter.

Alteplase (Activase) – inj – is used for very serious life threatening conditions such as:

Pulmonary embolism

Myocardial infarction: Only works for the first few hours of a heart attack. Unfortunately a lot of people are in denial in the beginning of a heart attack.

Stroke (clot): The stroke could be caused by a clot or by the opposite, bleeding. If you use this drug in a bleeding situation, death.

Indirect Acting

Streptokinase (Streptase) – inj – is dependent on the plasminogen in the bloodstream. Streptokinase stimulates conversion of plaminogen to plasmin. Plasmin is our bodies internal thrombolytic. Streptokinase is used for pulmonary embolism.

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