Here Engreitz et al. address the mechanism of X-chromosome inactivation and demonstrate that the X-inactive specific transcript (Xist) large noncoding RNA (lncRNA), which appears to mediate this process, localizes on the X-chromosome. They demonstrate that Xist initially binds to the genome around the Xist transcription locus but then spreads throughout the whole chromosome. This mechanism appears not to be dependent on any specific...

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