Health Encyclopedia

Ehlers-Danlos Syndrome

Definition

Ehlers-Danlos syndrome (EDS) is a group of inherited disorders. These disorders affect
the connective tissues. This type of tissue is found all over the body. There are at least 6 different varieties of EDS. They are classified by the type of tissue most affected and how it is inherited.

Causes

EDS is caused by a problem in the genetic material. It mainly affects the genes that create connective tissue.

Most types of EDS affect the production of collagen. Collagen is an important part of connective tissue. It gives the tissue strength and allows it to stretch.

Risk Factors

Having family members with EDS increases your chance of EDS.

Symptoms

The symptoms of EDS can vary. Some may have mild symptoms. Others may have severe and life-changing symptoms.

The most common symptoms of EDS include problems with the joints and skin. Joints are loose and unstable which can lead to:

Prevention

There is no known way to prevent EDS after a person is born. If you have EDS or have a family history of the disorder, consider genetic counseling when deciding to have children. The counselor can talk to you about the risk of your child having EDS.

Revision Information

This content is reviewed regularly and is updated when new and relevant evidence is made available. This information is neither intended nor implied to be a substitute for professional medical advice. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with questions regarding a medical condition.

Questions and Answers about Heritable Disorders of Connective Tissue.
National Institute of Arthritis and Musculoskeletal and Skin Diseases
website. Available at:
http://www.niams.nih.gov/Health%5FInfo/Connective%5FTissue/default.asp. Accessed August 14, 2013.