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Evaluation of the new Tcoag pre-calibrated assay TriniLIA™ D-Dimer II.

A great ISTH session was held July 8-13 in Berlin, Germany. Bronze sponsors, Stago Group were delighted to be a part of this biennial, mainstay event. Many great studies were presented this year, one of which was a new poster coming from Basingstoke and North Hampshire Hospital, Basingstoke, United Kingdom detailing a study lead by Helen Lewis and assisted by Katrina Harrison and Dr Jane Needham.

The team evaluated the new Tcoag pre-calibrated assay TriniLIA™ D-Dimer II. The aim of the study was to evaluate the new Tcoag TriniLIA™ D-Dimer II for application in the routine diagnostic service as a NPI of VTE and the robustness of a pre-calibrated assay on the Tcoag DT100 and Destiny Max analysers.

The DT 100 is the new fully automated benchtop coagulometer recently made available by Tcoag. Like its higher throughput counterpart, the Destiny Max, the DT 100 offers both optical and mechanical methodology and can perform all routine and specialty assays including automated and precalibrated D-dimer.

The authors concluded that the study demonstrated good performance of the TriniLIA™ D-Dimer II against the gold standard VIDAS D-Dimer Exclusion II; a robust pre-calibrated assay has many advantages in a busy diagnostic laboratory with the need for rapid turnaround times of results. The clinically validated proposed cut-off value for TriniLIA™ D-Dimer II used as a NPI for VTE is 0.5ug/ml (FEU).

Fig 1: A correlation of D-Dimer concentrations for the VIDAS and Destiny Max (µg/ml (FEU))

Biography of Dr Jane Needham: Dr Needham is a Consultant Biomedical Scientist, Trust Lead Scientist, Pathology Scientific Lead for Research & Development, Council member Institute of Biomedical Science . Her clinical interests include haemostasis & thrombosis clinical and laboratory diagnostics, translational research, clinical trials and diagnostic service development and member of the International Society on Thrombosis & Haemostasis.