INTERNATIONAL NORMALISED RATIO INCREASED Clinical Trials and Studies

Treatments might be new drugs or new combinations of drugs, new surgical procedures or devices, or new ways to use existing treatments. The goal of clinical trials is to determine if a new test or treatment works and is safe. Clinical trials can also look at other aspects of care, such as improving the quality of life for people with chronic illnesses. People participate in clinical trials for a variety of reasons. Healthy volunteers say they participate to help others and to contribute to moving science forward. Participants with an illness or disease also participate to help others, but also to possibly receive the newest treatment and to have the additional care and attention from the clinical trial staff.

Relationship between tonic Dopamine release (measured by displacement of [11C]-raclopride by oral methylphenidate) and change in processing speed between baseline and after methylphenidate treatment.; Relationship between D2/D3 receptor availability in ventral striatum and prefrontal cortex and neuropsychologic deficits.; Relationship between tonic Dopamine release in the ventral striatum and prefrontal cortex with neuropsychologic deficits after TBI.; Relationship between D2/D3 receptor availability and functional connectivity of the prefrontal cortex with nodes of the default mode network.; Relationship between TMS-induced short-interval cortical inhibition of M1 and tonic Dopamine release.; Test motivation and reward on and off methylphenidate in TBI patients.

Number of yawn; Number of eyelid blinking; Number of eyelid blinking in both groups after apomorphin or placebo injection; Neurophysiological assessment of the Dopaminergic reactivity; To test the correlation between the behavioral and neurophysiological markers of Dopaminergic reactivity in patients with epilepsy; To assess Dopaminergic reactivity with biological markers; Number of Adverse Events as a Measure of Safety and Tolerability; Check the absence of spike-wave discharges in healthy volunteers

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