Is she worried about the affect this will have on her career? How about on her singing voice?
She's hopeful that the percentage of fans that won't be cool with this will be small. She said, "I know our fans and it may be too much for some of them to take, but I know that a lot of them are open-minded and welcoming. I hope they'll come on this journey with me." The reaction I've seen has been almost all positive.
As far as her voice, she's not worried right now. So far the only kind of medical thing she's having done is hormones. She says the estrogen doesn't affect your voice. If she goes ahead with some of the cosmetic things – like tracheal shaving, which whittles down your Adam's apple – there's a possibility that might affect her voice. But she's really hesitant to do that because of that. As of right now, she should sound the same, as loud and aggro and awesome as ever, just as a woman.