1
Tu&Yuen Center for Functional Onco-Imaging,
University of California, Irvine, CA, United States,
2
Women
and Childrens Health and Well-Being Project, Department
of Psychiatry & Human Behavior, University of
California, Irvine, CA, United States

Hippocampal volume and shape analysis was applied to 103
children (6-10 years old) to evaluate the association
with their cognitive performance in different domains
(learning, memory, recognition). Radial distance mapping
and two non-rigid registration methods were applied to
analyze shape based on the deformation matrix. Results
obtained using these three different methods were
consistent, and they suggest that different hippocampal
regions are associated with different cognitive
performance tasks. Analyses done separately in males and
females showed similar results. None of the volumetric
measurements revealed significant correlations,
suggesting that shape analysis may provide a more
sensitive tool for subregional analysis.

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