Resident Evil 5 Walkthrough & Strategy Guide

To continue, head into the chamber they broke out of and use the conventional doorway out of that room. Once through the door, you'll again be out of danger, at least for the time being. Follow this linear corridor and seek out an office on your right as you head through the linear passageway. This room contains not only a Red Herb to add to your inventory, but perhaps more importantly, an AK-74 machinegun as well. While machineguns are all but useless in Resident Evil 5, this weapon certainly constitutes a step up for your automatic weapons, so be sure to grab it. Also be sure to open the safe in this room to be rewarded with quite a few dollars. Then, leave the room and continue along the passage until you come to a staircase, which you should take to the floor above.

This brief corridor will present you with a simple puzzle. First, head to the lever on the left wall and activate it. Then, head to the door ahead and, with your partner, go on through it. This next area provides you with a bit of a conundrum. There are Licker Betas in two chambers, one on each side of this hallway. They don't have great senses, so if you're extra quiet (simply walk and holster your weapons), you can actually get through this area without having to fight them. But if you're feeling extra daring, initiate hostilities with them. You'll end up having to deal with about ten of them or so, but this is nothing a maxed out M3 shotgun can't take care of rather easily (for instance). Doing this will likely net you more ammunition in dropped items than you expended defeating the foes, and more importantly, a pair of Lion Heart treasures can also be grabbed. Regardless of how you choose to go about this part, head left through the door at the far end of the stunted hallway, and then go through the door on your right.

From here, it's a straight shot to an elevator that will bring you down to an area below. First, be sure to grab all of the items from the breakable crates in your vicinity. Then, hail the elevator. It will take a while to get to you, so obviously, you'll be assailed by another group of vicious enemies at this point. Licker Betas will turn the corner and begin coming towards you. Break out your sniper rifle to damage and kill as many as possible before they get too close. Then, toggle to your pistol or, preferably, your shotgun, and lay waste to more of them. When the elevator comes, you can immediately duck onto it and get out of dodge, but if you're daring, stay around and kill the stragglers. Yet another Lion Heart will be your reward when you do. When the elevator lets you off, grab the ammunition in front of you, and then head rightward to the large, large room there. After a cutscene, it's boss fighting time.

This boss is certainly gigantic, but he's still a pushover (and then some). You just need to know exactly what to do to make quick work of him. And, of course, this goes without saying, but the more powerful your weapons are, the easier this enemy is going to be. With a maxed-out M3 shotgun, for instance, this boss battle will take all of sixty seconds. This creature has two primary weaknesses -- the red, fleshy sections of his legs, near the joint, and his mouth, but only when it's open. By striking these two areas with your pistol, machinegun, shotgun, or whatever you have, the foe will eventually become weak enough that he will slink to the ground in a temporary haze. This is the time when you have to strike.

When he slams to the ground, he will do so identically, whether he's been coerced to do so by leg injuries or strikes to the mouth. His mouth will open momentarily, so run up to him and quickly follow the on-screen prompt to chuck a grenade in his mouth. A few rounds of this, and he will be no more. If you need grenades (and other items, including ammunition), the little bugs released by this foe every so often will be a welcome addition to the battle for you. But with quick work, he might not even get to dispatch his first group. If you don't have grenades, simply shoot your gun-of-choice into his mouth. It won't have quite the same power (unless you're using a magnum or other powerful weapon), but it certainly is an alternative. For the naysayers out there, our video of fighting this boss is done with the M3 Shotgun only. So yes, the boss can be defeated (and rather easily so) even without any grenades on hand.