Abstract: With the reduction of Infant Mortality, there was a change in the profile of the deaths, highlighting the early and fetal neonates. Therefore, this study analysed the spatial distribution of the Perinatal Mortality Rate (PMR), in Paraná, from 2006 to 2014. This is an epidemiological research, ecological, with secondary data available from SIM, SINASC and IPARDES (BDEweb). The Perinatal Mortality Rate and its components have been calculated, organized in trienniums, and the variables have been categorised in maternal, newborns, caregivers and socioeconomic variables of municipalities. For data analysis, Binary Logistic Regression, Exploratory Spatial Data Analysis (ESDA), Local Indicator Spatial Association (LISA) and the Moran Index were used. A PMR of 15.3 deaths per 1,000 live births was identified, reduction of 11.7%, with a higher proportion for fetal deaths compared to early neonates. The risk factors identified for early neonatal mortality were: absence of partner, previous fetal losses, males, low birth weight, prematurity, Apgar less than seven in the fifth minute, congenital anomaly, and number of prenatal visits less than seven. The PMR reduction was observed with positive spatial autocorrelation analysed by the Moran Index (2006-2008: -0.647; 2009-2011: -0.707; 2012-2014: -0.550), and the municipalities present similar rates compared to their neighbors. The formation of a spatial conglomerate was identified in 5th Regional of Health, maintaining its PMR higher throughout the study period, despite the improvement of the indicators. In the multivariate analysis, there was a negative correlation for the variables IDHM (-0.240), urbanization degree (-0.158), and per capita household income (-0.191), and a direct correlation with the illiteracy rate (0.072). The conclusions were that there is a necessity of greater sensibility of the child risk stratification instrument; health professionals training; strengthening of the epidemiological surveillance service and the Committees for the Prevention of Infant and Fetal Mortality; need for research that detail the structure, process and results of maternal and child services. Finally, it is stated that the spatial analysis of PMR generated good scientific evidence for the managers of all spheres of health care in Paraná. Key-Words: Perinatal Mortality; Public Health; Epidemiology; Information Systems; Spatial Analysis.