ADAMTS12 encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Additionally we are shipping ADAMTS12 Kits (23) and ADAMTS12 Proteins (9) and many more products for this protein.

More Antibodies against ADAMTS12 Interaction Partners

ADAMTS-12 is a multifaced metalloproteinase in arthritis and inflammation [review]

ADAMTS-12 is implicated in the inflammatory response by modulating normal neutrophil apoptosis.

ADAMTS-12 plays protective roles acting against the development of asthma phenotype upon experimental allergen exposure, interfering with immunological processes leading to inflammation and airway hyperresponsiveness.

Results define a break point in mouse chromosome 15qA1 to a 27-kb region containing ADAMTS12, and show that the break is likely between exons 2 and 3 of ADAMTS12.

Absence of Adamts-12 is associated with the increase in angiogenic response and tumor invasion into host tissue.

ADAMTS-12 is a multifaced metalloproteinase in arthritis and inflammation [review]

ADAMTS-12 is implicated in the inflammatory response by modulating normal neutrophil apoptosis.

Our results suggest that ADAMTS12 may be a susceptibility gene for RA development.

statistically significant increase in mRNA expression of ADAMTS-7 (show ADAMTS7 Antibodies) and ADAMTS-12 was observed in the endplate cells in degenerative discs compared with nondegenerative discs

The data supported the hypothesis that genetic variations in ADAMTS12 influence the risk of schizophrenia.

expression of ADAMTS12 in colorectal cancer stroma plays an important role in inhibiting tumor development

This study identifies a novel biological role for ADAMTS-12, and highlights the importance and complexity of its non-proteolytic domain(s) pertaining to its function.

ADAMTS-12 is a new COMP (show COMP Antibodies)-interacting and -degrading enzyme and thus may play an important role in the COMP (show COMP Antibodies) degradation in the initiation and progression of arthritis

ADAMTS12 Antigen Profile

Protein Summary

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS-1) motif. Individual members of this family differ in the number of C-terminal TS-1 motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains eight TS-1 motifs. It may play roles in pulmonary cells during fetal development or in tumor processes through its proteolytic activity or as a molecule potentially involved in regulation of cell adhesion.