This conference, organized at Centro Nacional de Investigaciones Cardiovasculares (CNIC) on 4-5 November 2016 in Madrid (with Nadia Mercader as a co-organizer) will bring together world experts in the different fields of Mechanobiology (including liveHeart's Julien Vermot as a speaker). The conference will focus on mechanical forces as major determinants of the development, physiology and diseases of the cardiovascular system.