Cast in the hit comedy Bridesmaids alongside Kristen Wiig and Rose Byrne, she deservedly pratfalled her way to numerous awards and an Oscar nomination as Best Supporting Actress.

The same year, McCarthy won an Emmy for her work in the hit sitcom Molly & Mike. Her hosting stints on Saturday Night Live garnered more Emmy nominations and starring roles alongside Jason Bateman in Identity Thief and Sandra Bullock in The Heat were box office hits.

Now, the lovable star goes in front of the camera for her actor husband Ben Falcone, making his directorial debut, in this brash road movie. Tammy (McCarthy) works in a fast food burger joint and is a hazard to everyone around her.

On the way to work, she hits a deer and wrecks her car, then to rub salt into her wounds, her boss fires her. Arriving home early, Tammy discovers her husband Greg (Nat Faxon) in flagrante delicto with next-door neighbour Missi (Toni Collette).

With her world crumbling around her, Tammy decides she needs a change of scenery so she collects her profanity-spewing, hard-drinking grandmother Pearl (Susan Sarandon) and heads for Niagara Falls, which the old woman has always wanted to visit.

En route, Tammy discovers that she is mistress of her destiny after all.

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