Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The suppressive mechanisms occur not only by pretranslational inhibition of eNOSexpression but also by a posttranslational decrease in endothelial NO synthase activity due to a reduction in intracellular calcium levels.

The functional importance of the diminishedeNOSexpression was revealed by the finding that serum nitrite/nitrate levels among individuals carrying the -786T-->C mutation were significantly lower than among those without the mutation.

Previous studies in animal models have suggested that there may be an inverse functional association between the two NOS isoforms within the vascular wall, with an up-regulation of nNOS when eNOSexpression is reduced (Boulanger et al. 1998).

There is thus strong experimental evidence to support an important role for eNOS in the regulation of angiogenesis in animal models, however the implication of eNOSactivity in collateral vessel formation in response to myocardial ischemia in humans remains unknown

In pathological situations circulating pro-inflammatorycytokines induce the expression of iNOS and ET-1 in smooth muscle cells, also downregulating endothelial eNOSexpression, resulting in an elevated ET-1 production and a decrease of NO [18,39].