Help with Methylation

Hi,
I have been trying to help my 23 year old daughter (CFS for 6 months now) start on Fredd's methylation programme but I'm looking for some advice as it's not going so well.

We started off with the B-complex plus for 4 days
Then we added 1 Enzymatic Therapy B12 (1mg) for four days
Then we started on 1/4 tablet Dibencozide B12 (2mg) on alternate days for a week.

The first time she took the Dibencozide she noticed increased urination but that has sorted itself out

Next she tried the Solgar Folate 400mcg.

This is when she became much worse. Her fatigue increased greatly and whereas before she could do about 4 hours work at home she was too weary to do anything much and her concentration decreased. She describes it as feeling "totally blah".
We've reduced the Folate to every other day, but if anything this made matters worse - althought this could also be due to a stressful meeting.

Does this sound like a start up reaction? It seems quite a drastic change and she really needs to get back to her previous levels as she was trying to convince her supervisor that she could go back to work. Would it be best to decrease the B12 for a while?

Hi,
I have been trying to help my 23 year old daughter (CFS for 6 months now) start on Fredd's methylation programme but I'm looking for some advice as it's not going so well.

We started off with the B-complex plus for 4 days
Then we added 1 Enzymatic Therapy B12 (1mg) for four days
Then we started on 1/4 tablet Dibencozide B12 (2mg) on alternate days for a week.

The first time she took the Dibencozide she noticed increased urination but that has sorted itself out

Next she tried the Solgar Folate 400mcg.

This is when she became much worse. Her fatigue increased greatly and whereas before she could do about 4 hours work at home she was too weary to do anything much and her concentration decreased. She describes it as feeling "totally blah".
We've reduced the Folate to every other day, but if anything this made matters worse - althought this could also be due to a stressful meeting.

Does this sound like a start up reaction? It seems quite a drastic change and she really needs to get back to her previous levels as she was trying to convince her supervisor that she could go back to work. Would it be best to decrease the B12 for a while?

Any input would be much appreciated

Click to expand...

Hi Beachy,

You will likely find many of her symptoms in one or both groups for either low potassium and/or donut hole paradoxical folate insufficiency. These happen almost every the time that methylation is successfully started. hey are a flag of healing. Adjust the doses on potassium to prevent dangerous effects that can lead to death. Adjust the methylfolate until the symptoms disappear, keeping the same doses of active b12s. Since folate/b12 healing turns on by layers, it is NOT controllable by dose control. And turning healing on and off over and over againn makes things worse usually. By adjust the doses by reasonable amounts, in an adult the range of potassium needed in healing is typically 1200-3000 mg. The ranges of Metafolin goes from about 1600mcg to 20mg or so depending upon reactions to folic acid, folinic acid and /or veggie folates.

Version 1.2 12/08/2013

Group 1 – Hypokalemia onset. Symptoms may appear with serum potassium as high as 4.3. May become dangerous if ignored. Considered “rare” with CyCbl (cyanocobalamin) it is very common with MeCbl (methylcobalamin) and AdoCbl (adenosylcobalamin) and less so with HyCbl (Hydroxycobalamin).

There does not appear to be a clear order of onset. The order of onset varies widely from person to person but many appear consistent for each episode for any given person. There tend to be more and more intense symptoms as it gets worse. Some people have ended up in the ER because of not recognizing the symptoms.

These symptoms appear in 2 forms generally, the milder symptoms that start with partial methylation block and the more severe symptoms that come on as partial methylation block gets worse or very quickly with methyltrap onset.

Edema - An additional thing I would like to mention. I would never have found it without 5 years of watching the onset of paradoxical folate insufficiency and trying to catch it earlier and earlier and to figure out what was causing it and to reverse it. For me the onset order goes back to the day of onset now with edema and a sudden increase of weight. I noticed that within 2 hours of taking sufficient Metafolin I would have an increase in urine output.