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Claims for Patent: 6,317,629

Claims for Patent: 6,317,629

Title:

Iontophoretic drug delivery apparatus

Abstract:

An iontophoretic delivery device (10) is provided. Device (10) has an electronic circuit (32) having electronic components such as batteries (30) mounted thereon. Device (10) also includes a pair of electrode assemblies (18, 19). The electronic circuit (32) is electrically connected to the electrode assemblies (18, 19) using an electrically conductive adhesive (34). The adhesive can also be used to electrically connect two or more electronic components within circuit (32) or to connect an electronic component to the electronic circuit (32). In one practice of the invention, the electrically conductive adhesive (44) functions as an electrode and electrically connects the circuit (32) to an agent-containing reservoir (24, 25). In a further practice of the invention, the electrically conductive adhesive (93) functions as an agent reservoir and contains the agent to be iontophoretically delivered.

1. An iontophoretic agent delivery device comprising a pair of electrode assemblies, a least one of said electrode assemblies having a donor electrode and a reservoir for
containing the agent to be iontophoretically delivered, said reservoir being adapters to be placed in agent transmitting relation with a body surface through which said agent is to be delivered, an electronic circuit having a plurality of electronic
components including a source of electrical energy, and having a circuit output which is electrically connected to said reservoir, said electronic circuit being capable of controlling the electric current applied by the device, said device having an
electrically conductive pressure sensitive adhesive wherein the adhesive is conducting in all directions, the adhesive being in direct physical and electrical contact with said circuit output and the adhesive also being in electrical contact with at
least one member selected from the group consisting of an electrode assembly, an electrode and a reservoir, said adhesive comprising at least a portion of the electrical connection between the circuit output and the reservoir.

3. The device of claim 2, wherein the adhesive comprises (i) an anodic electrode and the electrochemically reactive species is capable of undergoing electrochemical oxidation; and/or (ii) a cathodic electrode and the electrochemically reactive
species is capable of undergoing electrochemical reduction.

4. The device of claim 1, wherein the adhesive is flexible.

5. The device of claim 4, wherein the adhesive is in the form of a flexible film or sheet.

15. The device of claim 14, wherein the additive is a hydrophilic polymer.

16. The device of claim 14 or 15, including a liquid releasing means in fluid communication with said adhesive.

17. The device of claim 15, wherein the hydrophilic polymer is cross-linked.

18. An iontophoretic agent delivery device comprising a reservoir, for containing the agent to be iontophoretically delivered, said reservoir being adapted to be placed in agent transmitting relation with a body surface through which said agent
is to be delivered, an electronic circuit having a plurality of electronic components including a source of electrical energy, and having a circuit output which is electrically connected to said reservoir said electronic circuit being capable of
controlling the level of electric current applied by the device,

said device being characterized by an electrically conductive adhesive in direct electrical contact with said circuit output said adhesive comprising at least a portion of the electrical connection of the circuit output to the reservoir,

including an anode and a cathode, and said outputs being connected to said anode and said cathode by said adhesive, said adhesive comprising a flexible, electrically conductive adhesive which adheres to said circuit outputs and said electrodes,
in at least a portion thereof, to connect said circuit outputs and said electrodes, wherein said adhesive is in the form of a film, sheet or web, said film, sheet or web having an opening therein, and wherein a wicking material is positioned in the
opening.

19. The device of claim 18, including a liquid releasing means in fluid communication with said wicking material.

20. An iontophoretic agent delivery device comprising a pair of electrode assemblies, a least one of said electrode assemblies having a donor electrode and a reservoir for containing the agent to be iontophoretically delivered, said reservoir
being adapted to be placed in agent transmitting relation with a body surface through which said agent is to be delivered, an electronic circuit having a plurality of electronic components including a source of electrical energy, and having a circuit
output which is electrically connected to said reservoir, said electronic circuit being capable of controlling the electric current applied by the device,

said device having an electrically conductive pressure sensitive adhesive wherein said adhesive is electrically conducting in all directions, in direct physical and electrical contact with said circuit output and the adhesive also being in
electrical contact with at least one member selected from the group consisting of an electrode assembly, an electrode and a reservoir, said adhesive comprising at least a portion of the electrical connection between the circuit output and the reservoir
wherein said adhesive has a resistivity of less than about 1.5.times.10.sup.5 ohm-cm.

21. An iontophoretic agent delivery device comprising a pair of electrode assemblies, a least one of said electrode assemblies having a donor electrode and a reservoir for containing the agent to be iontophoretically delivered, said reservoir
being adapted to be placed in agent transmitting relation with a body surface through which said agent is to be delivered, an electronic circuit having a plurality of electronic components including a source of electrical energy, and having a circuit
output which is electrically connected to said reservoir, said electronic circuit being capable of controlling the electric current applied by the device,

said device having an electrically conductive pressure sensitive adhesive wherein said adhesive is electrically conductive in all directions, in direct physical and electrical contact with said circuit output and the adhesive also being in
electrical contact with at least one member selected from the group consisting of an electrode assembly, an electrode and a reservoir, said adhesive comprising at least a portion of the electrical connection between the circuit output and the reservoir
wherein said adhesive comprises a carbon conductive filler.

22. The device of claim 21, wherein the conductive filler has an iodine absorption number greater than 750 mg/g.

23. The device of claim 21, wherein the conductive filler has an iodine absorption number greater than 1000 mg/g.

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