I own a marshall VS100 head with marshall VS 412 speaker
I also own a mesa boogie roadster with an oversized 412
I say VS100 has a unique tone that suits well with heavy rhythm stuff
very tight and straight up sound
it definitely sounds different than roadster
roadster sounds more 3 dimensional while VS100 sounds more straight
the lead sound sucks though..it is kinda strerile
my countour is around 9-10 oclock
treble 8 oclock, mid full, bass 10 oclock
and I use drive channel 2 for distortion, not drive channel 1
I keep both of my amps for different tones