RESULTS - The majority of the microaneurysms were oval in shape (86,4%), with no “capsule” (84.1%), with an heterogeneous lumen reflectivity (85.2%) and no associated cysts (65.9%). Their location in relation to the internal and external retinal boundaries (p=0.011) as well as nearby cysts (p<0.001) were correlated with angiographic leakage. No significant association was found between size, presence of a “capsule” and internal reflectivity on SD-OCT with the FA leakage status. Microaneurysms associated with cysts had larger vertical (p=0.001) and horizontal diameters (p<0.001).

CONCLUSIONS – A significant correlation was found between the presence of cystoid spaces in SD-OCT and detectable leakage on FA. In addition, cysts were found to be more frequent in the presence of larger microaneurysms, which may add some useful information regarding the pathophysiology of diabetic macular edema. The identification of high risk microaneurysms on SD OCT may help to establish a customized and more cost-effective strategy for follow-up and treatment in diabetic patients, without the need for invasive contrast imaging or OCT-angiography.