Novolog Mix 70-30

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For Patients

NovoLog Mix 70/30 (insulin aspart protamine and insulin aspart (rdna origin)) is used to treat type 1 (insulin-dependent) diabetes in adults. Insulin is a hormone that is produced in the body. Common side effects include redness, swelling or itching at the injection site. Effects usually go away after a few days or weeks.

NovoLog Mix 70/30 is typically dosed on a twice-daily basis (with each dose intended to cover 2 meals or a meal and a snack). Dosage is individualized. NovoLog Mix 70/30 may interact with albuterol, clonidine, reserpine, guanethidine, or beta-blockers. Many other medicines can increase or decrease the effects of insulin aspart and insulin aspart protamine on lowering your blood sugar. Tell your doctor all prescription and over-the-counter medications and supplements you use. Tell your doctor if you are pregnant before using NovoLog Mix 70/30. Consult your doctor to manage blood sugars before becoming pregnant. Your doctor may switch the type of insulin used during pregnancy. It is unknown if this drug passes into breast milk. Insulin needs may change while breast-feeding. Consult your doctor before breast-feeding.

Our NovoLog Mix 70/30 (insulin aspart protamine and insulin aspart (rdna origin)) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is Patient Information in Detail?

Easy-to-read and understand detailed drug information and pill images for the patient or caregiver from Cerner Multum.

Get emergency medical help if you have any of these signs of insulin allergy: itching skin rash over the entire body, wheezing, trouble breathing, fast heart rate, sweating, or feeling like you might pass out.

Hypoglycemia, or low blood sugar, is the most common side effect of insulin. Symptoms include headache, hunger, weakness, sweating, tremors, irritability, trouble concentrating, rapid breathing, fast heartbeat, fainting, or seizure (severe hypoglycemia can be fatal). Carry hard candy or glucose tablets with you in case you have low blood sugar.

Redness, swelling or itching at the injection site may occur. These effects usually go away after a few days or weeks. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Too much insulin can cause low blood sugar (hypoglycemia). This effect may also occur if you do not consume enough calories. The symptoms include chills, cold sweats, blurred vision, dizziness, drowsiness, shaking, fast heartbeat, weakness, headache, fainting, tingling of the hands/feet, or hunger. It is a good habit to carry glucose (sugar) tablets or gel to treat low blood sugar. If you don't have these reliable forms of glucose, raise your blood sugar quickly by eating a quick source of sugar such as table sugar, honey, candy, or drinking a glass of fruit juice or non-diet soda. Tell your doctor immediately about the reaction. To help prevent low blood sugar, eat meals on a regular schedule and do not skip meals.

This medication may cause low potassium levels in the blood (hypokalemia). Tell your doctor immediately if any of these unlikely but serious side effects occur: muscle cramps, weakness, irregular heartbeat.

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any of the following signs of a serious allergic reaction: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

SIDE EFFECTS

Clinical Trial Experience

Clinical trials are conducted under widely varying designs, therefore, the
adverse reaction rates reported in one clinical trial may not be easily compared
to those rates reported in another clinical trial, and may not reflect the rates
actually observed in clinical practice.

Hypoglycemia
Hypoglycemia is the most commonly observed adverse reaction in patients using
insulin, including NovoLog Mix 70/30 [see WARNINGS AND PRECAUTIONS].
NovoLog Mix 70/30 should not be used during episodes of hypoglycemia [see
CONTRAINDICATIONS and WARNINGS AND PRECAUTIONS].

Insulin initiation and glucose control intensification
Intensification or rapid improvement in glucose control has been associated
with transitory, reversible ophthalmologic refraction disorder, worsening
of diabetic retinopathy, and acute painful peripheral neuropathy. However,
long-term glycemic control decreases the risk of diabetic retinopathy and
neuropathy.

Lipodystrophy
Long-term use of insulin, including NovoLog Mix 70/30 (insulin aspart protamine and insulin aspart (rdna origin)) , can cause lipodystrophy
at the site of repeated insulin injections. Lipodystrophy includes lipohypertrophy
(thickening of adipose tissue) and lipoatrophy (thinning of adipose tissue),
and may affect insulin absorption. Rotate insulin injection sites within the
same region to reduce the risk of lipodystrophy.
Weight gain
Weight gain can occur with some insulin therapies, including NovoLog Mix 70/30 (insulin aspart protamine and insulin aspart (rdna origin)) ,
and has been attributed to the anabolic effects of insulin and the decrease
in glycosuria.

Postmarketing Data

Additional adverse reactions have been identified during post-approval use
of NovoLog Mix 70/30 (insulin aspart protamine and insulin aspart (rdna origin)) . Because these adverse reactions are reported voluntarily
from a population of uncertain size, it is generally not possible to reliably
estimate their frequency. They include medication errors in which other insulins
have been accidentally substituted for NovoLog Mix 70/30 [see PATIENT INFORMATION].