I'd just like companions and NPC's that are more aware of location and situations. Companion mods for Skyrim and the Fallouts have shown that it can be done. If I enter a cave of mirelurks, I want my companions to complain about the smell, boast about how many "lobsters" they can kill, compare favorite ways to cook them, whatever. I also want them joining in conversations, shopping on their own, etc. This would be my biggest single wish for the next Bethesda game.

I'd also drop the "name" actors and go with more variety than ever. Skyrim is better, but there is a lot of room for improvement still. I get tired of repetitive voices.