The 1st generation Acura TSX was available since 1997 in a 4-door sedan body style. The vehicle was powered by 2.4L (2,354 cc) Honda K24A2 i-VTEC DOHC I4 making 200 hp (149 kW) at 6800 rpm and 166 lb·ft (225 N·m) at 4500 rpm engine. In 2006 the engine was updated to produce 205 hp (153 kW) at 7000 rpm and 164 lb·ft (222 N·m) at 4500 rpm. The standard transmission was a six-speed manual while a five-speed automatic transmission was an option in Canada.

The 2nd generation Acura TSX was available since 2009 in a 4-door sedan body style. The standard engine was the same 2.4L (2,354 cc) Honda K24Z3 i-VTEC DOHC I4 making 201 hp (150 kW) at 7000 rpm and 170 lb·ft (231 N·m) at 4300 rpm. The 3.5L (3,471 cc) Honda J35Z6 VTEC SOHC V6 making 280 hp (209 kW) at 6200 rpm and 254 lb·ft (344 N·m) at 5000 rpm became available in 2010. The Acura TSX Sport Wagon was available since 2011 in a 5-door station wagon body style.