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Dr. Donovitz, whose company
BioTE Medical is a leading provider of
natural hormone replacement therapy using subcutaneous pellets, was critical of what he called a general lack of depth in research. Donovitz said, "We see significant flaws in the information that's being presented to the public. Studies based solely on pharmaceutical products are being applied to all testosterone therapy. As a result, credible research which is essential to a full understanding of testosterone therapy has not been considered."

The Wall Street Journal on
November 6, 2013 published an article that was critical of testosterone replacement therapy. The publication cited a research study of veterans which claimed that testosterone therapy raised the risk of heart attack and stroke by about 30%. Because the focus of the study was limited to pharmaceutical products, Dr. Donovitz said the research and its conclusions are flawed and incomplete. Dr. Donovitz added, "The study referenced in the Wall Street Journal article is limited to the synthetic gels, patches and shots which are being heavily promoted on television and radio. These pharmaceutical products use synthetic hormones and we've known about the dangers of synthetics for years. However, to be accurate and complete, any study of testosterone therapy needs to also include data for
natural hormone replacement. "

In addition to calling the Wall Street Journal research incomplete, Dr. Donovitz said that the study had other issues that impacted its integrity. According to Donovitz, many of the 23,173 veterans that were excluded from the study would have benefitted from proper testosterone optimization using natural hormone replacement. Donovitz also expressed concern that the sample, which consisted of elderly men, was skewed because of a high incidence of conditions such as hypertension, diabetes and hyperlipidemia. Another anomaly of the study, according to Donovitz, is the fact that of the 1223 skewed patients prescribed testosterone gels, patches and creams, only 20% filled one prescription. Donovitz added, "The level of patient monitoring and care after the procedure was not sufficient. 60% of the patients administered testosterone had follow up laboratory assessments of their serum testosterone. You cannot expect results without optimization and that requires laboratory assessment."

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