Abstract

More than 500 clinical trials are using mesenchymal stem cells (MSCs) in the world to treat some different diseases. The safety of expanded MSC transplantation is the most important thing to ensure that this therapy can become the routine treatment of human illnesses. More than five MSCs based stem cell drug products are approved in various countries demonstrated that expanded MSCs are safe in both local injection and transfusion. Moreover, some recent reports for six years followed-up clinical trials using expanded MSCs confirmed that there is not different tumorigenesis between the patients with and without expanded MSC transplantation. This letter aims to provide some evidence about the safety of expanded MSCs in clinical applications. However, the MSC quality should be strictly controlled during the in vitro MSC expansion.

Abstract

More than 500 clinical trials are using mesenchymal stem cells (MSCs) in the world to treat some
different diseases. The safety of expanded MSC transplantation is the most important thing to
ensure that this therapy can become the routine treatment of human illnesses. More than five
MSCs based stem cell drug products are approved in various countries demonstrated that
expanded MSCs are safe in both local injection and transfusion. Moreover, some recent reports for
six years followed-up clinical trials using expanded MSCs confirmed that there is not different
tumorigenesis between the patients with and without expanded MSC transplantation. This letter
aims to provide some evidence about the safety of expanded MSCs in clinical applications.
However, the MSC quality should be strictly controlled during the in vitro MSC expansion.

1. Dear Editor-in-Chief

In 2017, more than ten publications used expanded to treat some diseases in both local injection
and infusion in Pubmed [
1â€“10
]. All publications showed expanded MSC transplantation was safe.
Some studies followed-up 12 months, others followed up to 6 years. And some transplantations
are autologous, and others are allogeneic. In the recent report, Bartolucci et al. (2017) infused
allogenic expanded MSCs from umbilical cord tissue at the dose of 1 106 cells/kg to treat heart
failure and follow-up to 12 months [
1
]. At 12th months, only UC-MSC treated group significantly
improved the left ventricular ejection fraction. More importantly, there were no differences in
mortality, heart failure admissions, arrhythmias, or incident malignancy between treatment group
and placebo group [
1
]. In another study, Pang et al. (2017) reported the results of the clinical trial
using the allogenic expanded MSCs from bone marrow for aplastic anemia treatment [
8
]. After
the median follow-up of 17 months, the overall survival was 87.8%; there were 7/74 patients
developed a mild headache and fever, no other side effects were detected. With these results,
authors confirmed that allogenic BM-derived MSCs are safe in aplastic anemia [
8
].

In India, a four year-follow up study used autologous expanded MSC from bone marrow
to treat chronic stroke [
9
]. In this study, 12 chronic stroke patients were intravenously infused
with autologous expanded MSCs. All patients were followed up the 208th week without any cell
related side effects [
9
].

For local injection, two clinical trials using expanded MSCs with one clinical trial followed
up six years were reported. Centeno et al. (2017) lumbar degenerative disc disease-associated
radicular pain with autologous expanded MSCs. In this study, thirty-three patients injected with
their expanded MSCs and followed up to 6 years post-treatment. There was no any severe
side effect such as death, infection, and tumor in the patients related to MSC transplantation.
Particularly, up to 85% patients had a reduction in disc bulge size with average reduction size of
23% post-treatment [
2
].

I also found another report about safety and efficacy of Cx601 products in the treatment of
complex perianal fistulas in Crohnâ€™s disease [
3
]. This study was funded by TiGenix to investigate
the effectiveness of Cx601 â€“ a stem cell drug containing allogenic adipose tissue-derived stem
cells. The patients would be intralesionally injected with 120 million of Cx601 cells with the single
injection. Patients were followed up to 52 weeks post-treatment. The results showed that 17% of
patients treated with Cx601 and 29% patients in the placebo group had side effects included anal
abscess and proctalgia [
3
].

By these reports, I initially concluded that autologous and allogenic expanded MSC
transplantations are safe in both local injection and vein transfusion. However, more studies
with longer time follow-up are essential to perform the meta-analysis review about the safety
of expanded MSC transplantation.

2. Open Access

This article is distributed under the terms of the Creative Commons Attribution License (CC-BY
4.0) which permits any use, distribution, and reproduction in any medium, provided the original
author(s) and the source are credited.

3. List of abbreviations

BM: Bone marrow; MSCs: Mesenchymal stem cells; UC: Umbilical cord

4. Ethics approval and consent to participate

Not to be applied

5. Competing interests

The authors declare that no competing interests exist.

6. Funding

Not to be applied

7. Authors contributions

Both authors equally contributed in this manuscript, from preparing idea, looking references and
writing. All authors approved the final manuscript.

Copyright: The Authors. This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 4.0., which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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About journal

Progress in Stem Cell (PSC) (ISSN 2199-4633) is the best Open Access journal that acts as a forum for translational research into stem cell therapies. PSC is scientific journal that overlays the study of Cancer stem cells, Stem cell therapy, Stem-cell transplantation, human embryonic stem cells, Neural stem cells, Murine Embryonic Stem Cells, Adult stem cell, Pancreatic stem cells, etc. PSC is a peer-reviewed journal that focuses on the areas of established and emerging concepts in stem cell research and their assorted disease therapies. It provides an opportunity to share the scientific information among the clinical & medical scientists and researchers.