I'm new here and I dont know if this is the right thread so if it is, please move it to the right thread.

I recently formatted my hard drive and this version of Dolphin ran perfect with no crashes etc. Now for some reason when I click on the graphics configure button, Dolphin instantly crashes and I cant find a fix. Can anyone help me here?

I'd not delete the whole folder - you need to keep the subfolders called Wii and GC if you want to keep your saved games, for example. The issue's most likely with the folder called cache.

OS: Windows 10 64 bit Professional
CPU: Intel i5 4670K @3.4GHz... for now @4.6GHz with a quick and dirty (yet stable) OC. May get faster in a bit before the end of time.
RAM: 16GB (Down from 24 GB after some was given to siblings)
GPU: Radeon Vega 56

There isn't really anything else that's actually been loaded by that point - everything else is only accessed once a game is started.

OS: Windows 10 64 bit Professional
CPU: Intel i5 4670K @3.4GHz... for now @4.6GHz with a quick and dirty (yet stable) OC. May get faster in a bit before the end of time.
RAM: 16GB (Down from 24 GB after some was given to siblings)
GPU: Radeon Vega 56