The correlation between history of breastfeeding and the incidence of childhood acute leukemia in Semarang, Indonesia (#834)

Acute leukemia is
the most frequent childhood
cancer. Breast milk as the best nutrition for baby known has antimicrobial, anti-inflammatory and immune
modulatory components for preventing the occurrence of childhood infection
and malignancies a well.

Aim:

To
analyze the correlation between the history
of breastfeeding
and the incidence of acute childhood leukemia (Acute Lymphoblastic Leukemia (ALL) and Acute Myelocytic Lekemia(AML)
in Semarang Indonesia.

Methods:

A case
control study
involving acute leukemia patients aged 1-14 year-old at Kariadi Hospital Semarang in 2013 until April 2014.
The control group was age and gender matched healthy
children. The
parents were interviewed about breastfeeding history including
duration, tipe of breastfeeding and exclusive
breastfeed. Data about familial
malignancy, maternal radiation, infection and alcoholism were collected using a
questionnaire. Exclusive breastfeeding defined as the baby had breastmilk only until 4-6 month. Statistical analysis used
were logistic
regression and Mann Whitney

Results:

In total107 patients involved whereas ALL 85
patients (79.4%), AML 21 patients
(19.6%) and mixed leukemia 1 (0.9%). Exclusive breastfeeding
was more frequently found in healthy children than in lekemic (74.76% vs 53.27%), OR 0.385, 95% CI(0.21-0.68)p 0.001. The median of
breasfeeding duration was longer in healthy children 12.27 month (IQR 3-24) than
lekemic 1.5(IQR 1-8) p=<0.01 . By used regression analysis showed OR and 95%CI
for familial malignancy1.95(0.4-2.06)p0.16, infection 0.58(0.11-6.36)p0.88 and alcoholism
0.0 (0.0)p0.99 respectively.

Conclusions:

Exclusive breastfeeding is protective factor for
acute leukemia. Acute leukemia patients had breasfeeding shorter than healthy
children. Familial malignancy,maternal radiation,infection and alcoholism were not the risk
factors for acute
leukemia.