So I've been wanting to get into predator hunting , #1 too hopefully help with deer #'s in my neck of the woods and #2 it gives me a excuse to be in the woods year round. I'm trying to decide what rifle to go with for primarily coyote ? Any recommendations appreciated , thanks.

For coyote specifically, what are the advantages of .22-250 over .223/5.56mm? The cost of the ammo seems to be averaging about twice the cost of the .223 or more.

I've been thinking about a varmint gun. Can the .22-250 be done on an AR15 platform? Has anyone used the .223 WSSM round? Thanks.

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The cartridge isn't really that critical, anything will work. I agree with either the 223 or 243. I'd probably go with the 243 if I was purchasing a new predator rifle. But most important in my mind is I'd want a relatively light rifle with a short barrel (probably 20 - 22 inch.) As others have said the 243 is a good choice just due to the versatility and the fact that you can hunt deer with it too. But, if you're saving the fur, the 223 might be the best option for that reason.