Dire history aside, has the site of a 49ers-vs.-Packers tilt ever mattered less?

First, this is the 49ers’ earliest appearance ever in Green Bay. The forecast calls for sunny skies, temperatures in the low 70s, light winds and, most certainly, no tundra.

Second, these are Jim Harbaugh’s 49ers, a bow-to-nobody squad that went 6-2 on the road a year ago in his first season as coach, including four fourth-quarter comeback wins.

“To us, we don’t see it being at ‘Lambeau’ or anywhere else,” linebacker Patrick Willis said. “We just see it as being the first game of the season, and we want to win.”

NFC supremacy will be in the air, especially after the New York Giants lost their debut Wednesday night as reigning Super Bowl champions. The Packers and 49ers were the NFC’s top two seeds in last season’s playoffs before each lost at home to the Giants.

When it comes to Green Bay’s hallowed home, the 49ers players have spoken respectfully this week. But they’ve done so without any hint of intimidation.

“It’s not the loudest stadium we’ve played in,” left tackle Joe Staley said. “It does have history and tradition. But each game is a new game, each season is a new season.”

This game will be a tone-setter, rather than a season-altering experience amid Midwest foliage or snow-covered grass.

“Couldn’t ask for a better place to start the season,” said Alex Boone, who will make his first start at right guard. “It’s historical, and we’re ready to go.”

Of the 49ers’ past eight visits, the earliest — and start of the losing streak — came on Oct. 14, 1996, when they fell 23-20 in overtime. More lopsided losses followed, including in the January 1997 divisional playoffs (35-14) and 2002 wild-card round (25-15).

But this won’t be a maiden voyage for nearly half of the 49ers’ roster, as 24 players have experienced either the Nov. 22, 2009 trip (30-24 loss) or Dec. 5, 2010 game (34-16).

Not all memories of those trips are sour, either.

Michael Crabtree, who had a 38-yard touchdown reception in the 2009 visit, said of Lambeau: “It’s a good field. It makes me feel like I’m in high school. They’ve got the bleachers there, no seats. That’s the old-fashioned style. You don’t see those these days.”

That crowd of 73,094 needs to be blocked out of the 49ers’ minds, according to Harbaugh, who went 3-3 at Lambeau as a starting quarterback during his 15-year career.

Said Harbaugh: “You go in with your roster and your coaches, and there could be a smattering of your own fans there. It’s basically just us against a lot of them. But when you’re on the field, it’s 11 against 11.”

The Packers will be opening at home for the sixth time in seven years under coach Mike McCarthy. They won four of those openers, and last season they went 8-0 in regular-season home games for only the fourth time since 1978. They also own a 13-game, regular-season win streak at Lambeau.

No 49ers player knows Lambeau better than Randy Moss, and no player in the NFL has caught more touchdowns passes against the Packers. Moss has 13 regular-season scores against Green Bay, plus two more in a January 2005 playoff game when he was with the Minnesota Vikings. He has eight touchdowns in eight Lambeau visits.

“I look forward to going out here on Sunday on a historical field such as Lambeau,” said Moss, who is projected to start in what will be his first game since 2010.

Third-string quarterback Scott Tolzien is expected to merely observe Sunday’s game, something he’s familiar doing at Lambeau. He attended three games there as a fan, including once his junior year at the University of Wisconsin.

“It is probably the most unique game-day setting in the NFL as far as geography,” Tolzien said. “It’s basically plopped in the middle of a residential area. It’s weird. You’ll see signs in people’s front yards: ‘$15 for parking and a brat.’ “

Wouldn’t the 49ers rather see the Packers’ pass-happy attack on a cold, wintry day, however?

“It’s irrelevant,” said offensive coordinator Greg Roman. “Tell us when to show up.”

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