Summary: This paper proposes a novel dynamic channel assignment scheme named interference-aware dynamic channel assignment (IA-DCA) for the downlink of enterprise small-cell networks (ESNs) that employ orthogonal frequency division multiple access (OFDMA) and frequency division duplexing (FDD). In ESNs, a lot of small-cell access points (SAPs) are densely deployed in a building and thus small-cell user equipments (SUEs) have more serious co-tier interference from neighbor SAPs than the conventional small-cell network. Therefore, in the proposed IA-DCA scheme, a local gateway (LGW) dynamically assigns different numbers of subchannel groups to SUEs through their serving SAPs according to the given traffic load and interference information. Through simulation results, we show that the proposed IA-DCA scheme outperforms other dynamic channel assignment schemes based on graph coloring algorithm in terms of the mean SUE capacity, fairness, and mean SAP channel utilization.