Ganodermic beasts are monsters requiring a Slayer level of 95 to kill. They are found at the bottom of the Polypore Dungeon (this includes the Agility and resource section). Players cannot receive these as a Slayer task if their Magic level is below 60.

This monster has the highest Slayer requirement outside of Dungeoneering, breaking the previous record holder, ice strykewyrms. It is now tied with the Legiones in the Monastery of Ascension.

After the release of the Evolution of Combat, Ganodermic beasts had too low life points for their level. Jagex hotfixed this by placing Cabbage and low coin drops into their drop table as an extremely common drop. They have since been buffed and the coin and cabbage drops removed. The update also allowed them to drop Ganodermic boots and gloves.

During an update, Ganodermic beasts were accidentally made aggressive to players. This has been fixed.