The aim of this study was to develop UHPLC method for determination of impurities in pregabalin capsule formulation. Method development was based on quality by design approach (QbD). QbDis becoming more common approach because it saves time and reduces resources consumption. Development started with literature search. Firstly, optimal pH for separating the components was determined using Marvin Beans software. For three suggested pH values, three buffers were selected which are stable in appropriate pH ranges. Methods were developed using Fusion software which creates more methods with different chromatographic parameters, process data and later provides the parameters for the optimal method. Based on the results, dihydrogenphosphate buffer was selected with pH value 6,1. Four columns were tested with similar structure and properties that are most suitable for new method development. All four columns gave good results and the best was Fortis C-18 column. For the tested range of dilution, method is linear for both pregabalin and all impurities. Further experiments showed rapid column degradation so further method optimizations needed.