Welcome to week 10 on the NFL Talkboard. Pick your winners from these six games and submit your choices below the line. This week's live blog will be Giants @ 49ers – 4.15pm EST / 9.15pm GMT. Steve Busfield and myself will then be back on Tuesday with five things we learned from the weekend's games. Also, if you're on Twitter, follow our new service @GdnUSsports for all the latest US sports news, views, and live coverage.

But now it's time for the Pick Six. Approving whistles for Letdown, who picked all six games correctly last week, and also for James Dart (JD72), who became the first Guardian staff member to do so in a very long time, despite the fact that this is only something like the third time all season he's made picks at all. I shall post the overall standings below the line shortly.

Pittsburgh Steelers @ Cincinnati Bengals

Last week for the Steelers: a brutal physical battle against a division rival with a modest offence but a suffocating defence. This week? More of the same. Cincinnati's schedule over the first half of the season might not have been the toughest, but with six wins from eight games they can no longer be dismissed. Cincinnati's defence ranks fourth in the league – just behind Pittsburgh's – and their offence, led by the rookie Andy Dalton, is protecting possession and playing intelligent football. They are on their best winning streak for more than two decades. But do I yet have enough faith to back them in a game like this one? Not quite.Steelers to win

Jacksonville Jaguars @ Indianapolis Colts

Could this be a defining moment for Andrew Luck's future? The Colts are the only team left without a win, and they will have no better opportunity to change that fact. The only other team with a losing record on their remaining schedule is the Carolina Panthers, who beat the Jags earlier this year. Indianapolis also have a road game against Jacksonville in week 17, but you have to imagine their chances are better at home. Blaine Gabbert is one of only two quarterbacks with a worse passer rating than Indianapolis's Curtis Painter. Of course, the Colts' defence is also a mess and the injuries are stacking up, but still.Colts to win

Detroit Lions @ Chicago Bears

Somewhere along the way, the Bears offensive line remembered how to block. The same unit that allowed 11 sacks of Jay Cutler in their first two games, did not give up one against the Philadelphia Eagles, and their improved play is the single biggest key to why this team has won its last three straight. Their last defeat, indeed, came against the Lions – though that day a large chunk of the blame was assigned by Bears' coaches to the raucous Ford Field support who helped cause a staggering nine Chicago false starts. That won't be a factor on Sunday, but the Bears' inability to cover Calvin Johnson just might.Lions to win

New York Giants @ San Francisco 49ers

As NFL.com's preview notes, Eli Manning and Alex Smith are ranked fifth and sixth respectively in the league for passer rating this season. Who saw that coming? What I can see coming this weekend is a large dose of Frank Gore against a Giants defence that has often struggled against the run.49ers to win

New England Patriots @ New York Jets

Oh boy. The AFC East is tougher to call than your Amish auntie – the Patriots suddenly looking a long way short of the force they have been in recent seasons and finding themselves wedged alongside the Jets and Bills on 5-3. The Jets, clearly, are the team with momentum, having won their last three games – while the Patriots have lost back-to-back games against the Steelers and Giants. But New England have not lost three in a row since 2002. Veterans of this board will know the old rule about never picking against the Patriots. Despite all the evidence pulling me the other way, I'm going to stick by it.Patriots to win