Imperial College London (ICL)

London, United Kingdom

Posted about 2 months agoExpires on June 11, 2019

We are seeking bright, highly motivated and ambitious bioinformaticists to proactively develop and support the delivery of “Big Data” analytics within the UK Dementia Research Institute’s Multi-`omics Atlas Project (MAP). We invite both graduate (research assistant) and postdoctoral (research associate) level applicants.

The UK DRI Centre at Imperial College London (https://www.imperial.ac.uk/dementia-research-institute/) has been established as one of seven national centres of excellence embedded in major UK universities that together intend to transform the treatment and care for people with dementia and lead the way in early diagnosis and prevention. Our centre addresses dementia in the context of brain changes over the lifespan, homeostatic mechanisms and influences of environment and lifestyle. We develop new tools for discovery of disease mechanisms and directly address the identification of new therapeutic targets and treatment concepts. Our clinical leadership fosters a translational environment enabling discoveries in the human diseases, as well as in animal or cellular models.

Duties and responsibilitiesWith training as appropriate, you will contribute to the design and analysis of large-scale `omics datasets with a primary focus on single cell/nuclear RNA-Seq and network analysis to address major research questions related to the dementias. You will work closely with a team experienced in bioinformatics, sequencing methods and molecular neuropathology. This would offer a substantial opportunity for career development in this exciting area of biomedical research and development.Activities will include the development and documentation of analysis workflows and protocols for quality control, transcription profiling or epigenetic modification detection, as well as integration with genomic datasets and public and commercial biomedical data sources. Important aspects of the role also involve making strategic contributions to experimental design. Essential requirementsWe are seeking both graduate (Assistant) and postdoctoral (Associate) level bioinformaticists. Applicants should have a first degree in quantitative sciences or engineering, and/or a PhD in quantitative sciences or engineering. Both positions require a solid understanding of statistics and demonstrable experience of coding, algorithm development and application.