Abstract

Background Diabetes mellitus (DM) is an independent risk factor for complications following cardiac surgery. We examined peripheral gene expression and clinical responses to cardiopulmonary bypass (CPB) in patients with and without DM.

Conclusions The gene expression profile following CPB is quantitatively and qualitatively different in diabetic patients. Clinical correlation suggests that differential TR3 expression is associated with postoperative weight gain, likely due to vascular endothelial dysfunction and tissue edema. These results have possible implications for the design of tailored operative strategies for diabetic patients undergoing CPB.

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