Wednesday, 24 April 2019Paradigm Biopharmaceuticals Ltd (ASX:PAR) has successfully completed the institutional component of its fully underwritten accelerated non-renounceable entitlement offer to raise about $9.8 million. The retail component of the entitlement offer will open today and is expected to raise about $16.5 million, providing a total equity raising under the entitlement offer of about $26.3 million. Retail entitlement offer Eligible shareholders may participate in the retail entitlement offer at the same price ($1.50 per share) as the institutional offer at an offer ratio of 1 new share for every 8 shares held. The retail entitlement offer closes at 5.00pm (AEST) on May 6, 2019. READ: Paradigm Biopharmaceuticals raising $77.9 million to fund its pivotal phase 3 OA trial Along with the entitlement offer, Paradigm has raised $51.6 million via a placement to professional, institutional and sophisticated investors across Australia, Asia and the US. The new funds will allow Paradigm to advance its pivotal phase 3 OA clinical trial in the US, EU and Australia. The funds will also be used to complete the phase 2/3 pivotal clinical trial in MPS. READ: Paradigm Biopharmaceuticals phase 2b trial achieves key endpoints in OA of the knee The company has already successfully achieved the endpoints of improved knee function and pain reduction for its phase 2b trial in OA of the knee. The clinical trial subjects receiving Paradigm’s injectable pentosan polysulfate sodium (iPPS) were shown to have reduced bone marrow lesion (BML), indicating the possible regression of the disease.

Overall box office receipts this weekend are sluggish this weekend, which is shaping up to be the worst in nearly 15 years (since Miss Congeniality 2 took the top spot in 2005). There’s a fairly good reason for that: Easter weekends typically do not fall the weekend before the release of Avengers:...

Tilray said first-quarter revenue rose 195% from a year earlier to $23 million, as sales in Canada surged following the country's decision to legalize cannabis for recreational use. The adjusted loss..