With the wind blowing in on a cold summer night, Devin Mesoraco's five-game homer streak came to an end. The Reds catcher was tied with Adam Dunn, Ken Griffey Jr., Johnny Bench, George Crowe and Ted Kluszewski for the franchise record.

Latos (1-0) allowed one run and five hits in his third start after beginning the season on the disabled list. It was his first win since Sept. 20 against Pittsburgh.

Latos was coming off a frustrating no-decision against Toronto, when he was staked to an 8-0 lead and was unable to hold on. He gave up five runs and nine hits in 5 2-3 innings as the Blue Jays rallied for a 14-9 victory Friday night.

Edwin Jackson (5-8) allowed four runs and six hits in 5 1-3 innings for Chicago, which has dropped four of five. Starlin Castro had two hits and drove in a run.

The Cubs lost two of three against the Reds to fall to 12-31 against Cincinnati over the last three seasons.

Pinch-hitter Justin Ruggiano doubled off the front of the basket in right field with two outs in the ninth. The call was upheld after Cubs manager Rick Renteria called for a review, and Chapman struck out pinch-hitter Mike Olt to end the game.

Cincinnati went ahead to stay with three runs in the sixth. Todd Frazier scored from first on Joey Votto's opposite-field double to left. After Mesoraco's single, Bruce lined a double off third baseman Luis Valbuena's glove to drive in Votto.

Jackson struck out Chris Heisey before James Russell came in, and Skip Schumaker executed a perfect suicide squeeze to give the Reds a 4-1 lead. Schumaker also had two doubles in a nice night at the plate.

Bruce put the Reds in front with a two-out double down the right-field line in the first, scoring Frazier from second. Votto tried to hustle home from first but was cut down at the plate on Darwin Barney's relay throw.

The Cubs tied it in the fourth. Ryan Sweeney reached on a leadoff double, advanced on Anthony Rizzo's groundout and scored on Castro's base hit.