PXL Double Layer Filter Media

PXL Double Layer Filter Media – Effective High Solid Filtration

Complex of Filtration Mediums

PXL media is a complex of filtration mediums that enable significantly improved throughput and superior contaminant retention in high solids loading processes. Designed specifically for applications as an initial prefilter or clarification stage filter, PXL media is ideal for protecting price and contaminant sensitive process steps further downstream.

Applications

PXL media is designed to be the upstream bioprocessing filtration workhorse in those soft particulate, high cell count/low viability applications that readily foul the surfaces of other depth filter media. Filtering these solutions with regular depth media results in a rapid decline and termination of flow rate and throughput.

PXL media optimizes the filtration of soft particulate solutions over time by:

Reduced fouling rate of the filter

Reduced rate of operating pressure buildup

Increased flowrate and throughput per setup

Process Improvements

The effect of process improvements can be felt through cost savings in time and materials. Nowhere is that more evident than with the results seen with improved throughput that comes with the use of PXL media. With typical throughput improvements averaging 3 to 4x, the time involved in initial solids removal can be dramatically reduced and the amount of filtration area necessary can be significantly lowered all amounting to reduction in processing step costs.

With such dramatic improvements in solids removal through the use of ErtelAlsop’s new PXL filter media, the use of other more expensive and capital equipment intensive techniques become less attractive. For example

Centrifuges pose problems due to their lack of flexibility in sizing and their expense in ever larger systems as process scales increase.

Chemical flocculants, while promising, lack federal approval and longer term effects on product stability, efficacy and patient exposure have yet to be fully studied.

Filter presses, still widely used in some markets, lack closed processing, are labor and capital intensive.

Available Product Range/Scalable Formats

ErtelAlsop has made PXL media available in six different sizes of scalable, single-use disposable MicroCap capsules as well as 12 inch and 16 inch diameter lenticular filters for use in housings. Effective filter areas (EFA) range from as little as 23cm² to as much as 3.8 m² per 16 inch Pak cartridge.

ErtelAlsop’s 12 inch diameter and 16 inch diameter lenticular filters are available in a number of different formats containing either flat gasket or locking double o-ring end fittings.

BenefitsApplicationsDownloads

High purity

USP Class VI tested

Fully lot traceable

Low endotoxin content

Supported through Validation Guide

Some of the applications for PXL media are:

Bulk Fermentation Cell and Debris Removal

Bacteria

Yeast

Mold

Mamalian Cell Culture Clarification

Most other viscous bioprocess solutions with a high concentration of soft particulate

ErtelAlsop also offers a Validation Guide to assist in the validation of its filter pads in your process. The Validation Guide contains information regarding raw materials, extractables, and general information about the product. The combination of ErtelAlsop “P” grade filter pads and ErtelAlsop’s BioClean®plate and frame filter press design, can help to simplify your depth filtration validation now more than ever.

The Format to Fit Your Needs

As with all ErtelAlsop presses, filter media is available for any application and/or operating condition, and is chosen based on your specific operating conditions. ErtelAlsop offers the widest varieties of filter media and construction techniques to provide good particle retention, clear filtrate, high flow rates, and dry filter cakes.

Made in the USA

ErtelAlsop is an innovator in the manufacturing of depth filter media and machinery for liquid filtration since the 1920’s, and is your one source for all depth filtration and liquid processing products. ErtelAlsop’s customer base is filled with clients who have been buying from us for over 80 years.