Diffuse optical tomography (DOT) using near infrared (NIR) light has become a promising modality because it has the capability to non-invasively quantify oxygen saturation and hemoglobin content with potentially high temporal resolution and...

Our aim is to enhance high-throughput applications of Nuclear Magnetic Resonance (NMR) through the development of efficient computational methods that operate on sparse (minimal) sets of experimental NMR data. We have developed a family of four...

Endoplasmic reticulum (ER) homeostasis requires the coordination of anabolic and catabolic activities. A primary function of the ER is the biosynthesis and export of secretory proteins and lipids. Anterograde transport of only properly folded and...

The ability to forecast the weather of the geospace environment depends critically on the ability to accurately model the dynamics of the coupled magnetosphere-ionosphere (MI) system. The MI interaction involves a set of electrodynamic and plasma...

Dartmouth-College Lottery, Class First. Portsmouth, State of New Hampshire. According to an Act of the General-Court, passed November 3, 1784, this ticket [No. 3203] entitles the possessor to recieve such prize as may be drawn against it's number,...

From deciding what to eat first or what stock to invest in, the order in which we prefer to experience events and the amount of risk we are willing to undertake are factors that influence our choices. However, the mechanisms underlying order and...

The general objective of the current thesis was to investigate the neural substrates underlying the perception of opposite-sex faces. Building on what is already known about the distributed network of brain areas supporting various dimensions of...

In this dissertation, I present an examination of the role of two biotic interactions in the population dynamics of Vibrio cholerae. Traits with a genetic basis such as size, physiological processes, stress tolerance, and even behavior, are key...

In this thesis we look at several problems that lie in the intersection between combinatorial and multiplicative number theory. A common theme of many of these problems are estimates for and properties of the smooth numbers, those integers not...

Wnt/[beta]-catenin signaling directs metazoan development and is aberrantly activated in many cancers; however, effective inhibitors to treat Wnt-driven cancers have long been elusive. Following the recent discovery that the ADPribose polymerase...

In this thesis, we present different approaches to tying knots using robots by enforcing different types of constraints. We attack the problem from three different directions; mechanical design, motion planning with simple control strategies, and...

Chromium(VI) is a human carcinogen and causes DNA damage following reduction by intracellular reductants. In order to explore the effects of intracellular reductants on the carcinogenicity of Cr(VI), the roles of glutathione and ascorbate in...

A two-dimensional continuously-stratified model is derived for the study of instability properties of oceanic density fronts in the presence of sloping bottom topography. While the model retains several traditional assumptions, such as uniformity...

The central topic of the self has proven a vexing conundrum for philosophers and psychologists alike for centuries. Prior research suggests that the self is a powerful cognitive structure which biases attentional mechanisms in favor of apprehension...

The study of three-dimensional protein structures produces insights into protein function at the molecular level. Graphs provide a natural representation of protein structures and associated experimental data, and enable the development of graph...