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Central Coast Mariners coach Phil Moss is looking to the AFC Champions League to provide the catalyst for a much-needed change in fortune for the reigning A-League champions.

The Mariners are in the midst of a four-match losing streak - their worst run since 2009 - going into their Champions League opener away against South Korea powerhouse FC Seoul on Tuesday.

The match marks the Mariners' fourth appearance in Asia's premier club competition, with the club's best result coming last season when they reached the last 16 before being eliminated by eventual champions Guangzhou Evergrande.

"This has come at a perfect time for us to get away from Australia and come into a camp-style situation and refocus on what is important," said Central Coast coach Phil Moss.

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"Despite the results we have been having lately, it is a very tight knit group.

"We are not far from turning things around."

Although the K-League season does not commence for another fortnight, Central Coast will face a major challenge at the Seoul World Cup Stadium as FC Seoul are one of the biggest clubs in Asia and they've reached two Champions League finals, including last season.

There is also extra local focus on the Mariners as they'll line up with recent acquisition, former FC Seoul striker Kim Seung-Yong, in their forward line.

"It is a privilege for us to have Kim on our books (against his old club)," said Moss.

"None of us want to let him down, so it is a great challenge for us."

Defender Eddy Bosnar and forward Mile Sterjovski were both omitted from the squad with back soreness, with the sixth-placed Mariners in the midst of three matches in eight days and a derby against Sydney FC looming on Saturday.

The match in Seoul marks the first of six group stage outings for the Mariners over the coming two months, as it does for Western Sydney Wanderers and Melbourne Victory who commence their ACL campaigns on Wednesday.

And while some A-League clubs have previously been accused of not taking Asian club competition seriously, Moss says the Mariners are again fully embracing the challenge.

"This is a different style of competition, and a different culture we are faced with so it is an eye-opener for those who haven't experienced it before," he said.

"For those that have, this competition is a breath of fresh air and a real privilege to be involved in."