MT-1&lpar;Melanotan-1&rpar;CAS&colon; 75921-69-6 Alias&colon; Melanotan-1&comma; Melanotan I MF&colon; C78H111N21O19MW&colon; 1646&period;845Purity&colon; 99&percnt;Specification&colon; 10mg&sol;vial Appearance&colon; White Lyophilized PowderStorage&colon; Lyophilized peptides although stable at room temperature for 3 months&comma; should be stored desiccated below -18° C&period; Upon reconstitution of the peptide it should be stored at 4° C between 2-21 days and for future use below -18° C&period;

2&period;Product info&colon;

Melanotan 1 &lpar;also referred to as Afamelanotide&rpar; is a synthetic peptide variant of a peptide hormone&comma; called alpha-Melanocyte stimulating hormone or MSH that is naturally produced in the body and is responsible for stimulating melanogenesis&comma; a peptide process for pigmentation of the skin&period; Alpha-MSH activates certain melanocortin receptors in the process of exerting its effects&period; Indeed&comma; MSH also exerts potent influence over lipid metabolism&comma; appetite&comma; and sexual libido via these melanocortin receptors&period; As a result&comma; Melanotan-1 sunless skin tanning effects&period; While Melanotan 2 and PT-141 have been studied at length as a potential remedies for the treatment of sexual dysfunction&comma; Melanotan-1 has been researched extensively for use in protecting against the harmful effects of ultraviolet radiation from sunlight due to its melanogenesis-stimulating properties&period;

Both Melanotan-1 and Melanotan 2 are analogs of the peptide hormone alpha-melanocyte stimulating hormone &lpar;α -MSH&rpar; that tend to induce skin tanning&period; Unlike Melanotan 1&comma; Melanotan 2 has been shown to have aphrodisiac properties&comma; the additional effect of increasing libido&period; Melanotan-1 is a non selective agonist of the melanocortin receptors &lpar;MC1R&comma; MC3-5R&rpar;&period; As an analogue of α -MSH&comma; its mechanism of action is biomimicry of the natural mammalian tanning process&period;

3&period;Description and use &colon;

Melanotan-1&lpar;MT-1&rpar; sometimes referred to as Afamelanotide&comma; is a synthetic alpha-melanocyte stimulating hormone &lpar;a-MSH&rpar; peptide analog first developed at the University of Arizona and later by Clinuvel&period;&period;

It acts on the melanocortin system and induces melanogenesis in human and animal trials&period;MT-1 can induce tanning in human volunteers who are known to tan easily in response to sunlight&period; Latest studies suggests that MT-1 has a highly effective for treatment of erythropoetic protoporphyria&period;

In the US about two-thirds of patients suffered erythropoetic protoporphyriaare receiving MT-1 as treatment&comma; most of them claim that their symptomatic relief met expectations&period;

4&period;Different doses&colon;

first &comma;i have to say that's very important to expose all parts of the body to equal amounts of sunlight or ultraviolet radiation&period;

-->>&period;The loading phase &colon;Dosages is 0&period;5 to 2mg are injected subcutaneously daily&period; normally about 7 to 10 days

--->>&period;The maintenance phase&colon;Usually the maintenance phase dose is 0&period;5mg taken twice per week &period;while&comma;This might be different depending on person's reacts&period;

If the tan is getting lighter the dosage might be increased &comma;and short the period between injections&period;however If getting to dark the dosage should be lowered or the injection frequency decreased&period;

Melanotan-1 Mechanism of Action &colon;

Melanotan produces its photoprotective effects by triggering a 'signaling cascade' via its activation of the MC1R on melanin-producing cells known as melanocytes&period; Upon Melanotan binding with the MC1R on the surface of melanocytes in the epidermal layer of the skin&comma; it begins a series of actions and reactions that result in melanocytes favoring the production of eumelanin &period;

5&period;Melanotan 1 and Melanotan 2&colon;

Melanotan's peptide structure is almost the same as our endogenously produced melanocyte-stimulating hormone&period;

Melanotan 2 has a shorter sequence of amino acids slightly different than melanotan 1&period; MT2 can bind to the melanocortin-3 and 4 receptors and this binding will cause increases a side effect of sexual arousal&period;

Some people choose MT-1 because it causes tanning with less side effects then Melanotan 2&period; while &comma;on a mg for mg basis effectively you need less in terms of milligram weight of MT II to achieve tanning results compared to MT1&period;