Aim: The purpose of this study was to investigate the sealing ability of three different resin cements for the luting of a porcelain laminate veneer (PLV) to the enamel and dentin of fluorosed teeth. Materials and method: Thirty incisors with moderate fluorosis according to the Thylstrup-Fejerskov Index (TFI = 4 to 6) received a veneer preparation with dentin margins at the gingival third. The IPS Empress (Ivoclar Vivadent) veneers were luted to the teeth of three groups (n = 10) using three different resin cements: Group 1: Excite DSC/Variolink II - etch-and-rinse (E&R), Group 2: ED Primer II/Clearfil Esthetic - self-etch (SE), Group 3: RelyX Unicem - self-adhesive (SA). After 24 h of water storage and thermocycling, marginal microleakage was evaluated on three slices from each tooth using the dye penetration technique under a digital microscope. Results: Data (microleakage percentage over the entire preparation length) were analyzed using the Kruskal-Wallis and Mann-Whitney tests (P < 0.05). Mean microleakage percentage was 0.8% to 18% at the enamel and dentin margins, respectively. On the enamel, Group 1 (E&R) exhibited significantly less microleakage compared to Groups 2 (SE; P = 0.03), and 3 (SA; P = 0.005). On the dentin, microleakage in Group 3 (SA) was significantly less than that in Groups 1 (E&R, P = 0.001), and 2 (SE; P = 0.03). The difference between the latter two groups was significant, with Group 1 (E&R) exhibiting the greatest microleakage. Conclusion: The best enamel and dentin sealing of the cemented veneers was obtained with the E&R and SA luting agents, respectively.