There are several types of oral cancers, but around 90% are squamous cell carcinomas, originating in the tissues that line the mouth and lips. In the present study, we assess the frequency of mouth and lip cancer, different grades and treatment strategies in various groups divided on the bases of age, economic and marital status. The data was collected from the biochemistry department of the Institute of Radiotherapy and Nuclear Medicines (IRNUM) cancer hospital, situated in Peshawar, Khyber Pakhtunkhwa (KPK),in a period of January to December 2010. Data analysis indicated that there were 77 cases of oral cancer, including 66% males and 34% females. The results showed that people in age groups 51-60- and 61-70 were mostly affected (27.27%). Most of the patients (51.95%) were treated with radiotherapy (RT). Majority presented in the well-differentiated grade 1 (42.86 %). The high Incidence rate was investigated in married patients (4.81%). The most affected peoples occupation wise were house wives (28.57%), including lip patients (22.50%) and tongue patients (35.13%) followed by farmers (15.85%), including oral lip patients (15%) and oral tongue patients (16.21%). The other common site was oral lip cancer (52%). Data analysis revealed that out of 40 oral lip cancer patients, 40% were males and 12% were females. A large number of oral lip cancer patients (50%) were treated with radiotherapy. Predominant incidence (32.50%) was in the well differentiated grade 1. The married diseased subjects were highly affected (95%) as compared to unmarried. Radiotherapy was the most common treatment (50.05%). Advance age groups, especially house wives and farmers were mostly affected by mouth and oral lip cancer. Mostly the cancer was in the well-differentiated grade 1, treated mainly by radiotherapy.