Datasheet Extract

Immunogen

Immunogen:

This antibody was developed against a synthetic peptide corresponding to amino acids 321-333 (P1244) of human Pellino 1 and amino acids 5-20 of human Pellino 3 (P1245). Pellino 1 antibody will cross-react with mouse and rat Pellino 1 and Pellino 3 antibody will cross-react with Pellino 3a and 3b and mouse and rat Pellino 3.

Background

Pellino 1 is the mammalian homologue of Pellino, a Drosophila Pelle-interacting protein. Pelle is a serine-threonine kinase through which Toll signaling can occur. Pellino 1 can activate c-Jun, Elk-1 and NF-kB, whereas Pellino 3 can only activate c-Jun and Elk-1(2).