Rather than clog up the official thread, I'll make a new one with my thoughts.

Initial impression. Enemies on depth 50 hit VERY hard. If I didn't have a high con race I'd have died to the first enemy I encountered despite 11 melee 8 evasion (a plant). The spider poisoned me for 8 twice, that's a lot at depth 50 (although it's normal depth is 150, 2d6 is still a lot for that depth). Also despite my 8 evasion, and their very low melee, they rarely miss, while I miss more often than I would in Sil vs a similar enemy. So far I'm finding this significantly more difficult, which the manual said the high depths were meant to be easier.