Many cellular functions are based on the rhythmic organization of biological processes into self-repeating cascades of events. Some of these periodic processes, such as the cell cycles of several species, exhibit conspicuous ...

We investigate the dynamics of cell signaling using an experimentally based Boolean model of the human fibroblast signal transduction network. We determine via systematic numerical simulations the relaxation dynamics of ...

Background: With increasing computer power, simulating the dynamics of complex systems in chemistry and biology is becoming increasingly routine. The modelling of individual reactions in (bio)chemical systems involves a ...

The histone variants macroH2A1 1 and macroH2A2 are associated with X chromosome inactivation in female mammals. However, the physiological function of macroH2A proteins on autosomes is poorly understood. Microarray-based ...