NASA astronauts Neil Armstrong and Buzz Aldrin assemble the American flag on the moon during their Apollo 11 lunar landing mission in July 1969.

NASA

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It goes without saying that NASA's historic launch of the Apollo 11 moon landing mission 45 years ago today changed the face of humanity, and nowhere does that resonate more than in orbit, where astronauts live and work on the largest manmade structure off planet Earth: the International Space Station.

"When Apollo 11 landed on the moon 45 years ago, this space station that we live on was science fiction," station commander Steve Swanson of NASA said in a new video on the Apollo 11 anniversary. "But today it is a reality thanks to the legacy of the Apollo astronauts, and all of the nations who have followed the path to space since then."

"Today, we'd like to salute the Apollo 11 crew," said NASA astronaut Reid Wiseman, who joined Swanson in the video. "Forty-five years ago, Neil Armstrong, Buzz Aldrin and Michael Collins embarked on humanity's boldest journey. Apollo 11 not only achieved its mission to perform a manned lunar landing and return safely to Earth, it raised the bar of human potential."

In 1969, NASA and the United States were racing the Soviet Union to the moon. Since that epic Space Race, Russia and the United Space have become close partners in space. NASA and Russia's Roscosmos agency are two of the five space agencies overseeing the $100 billion International Space Station. (Space agencies from Europe, Canada and Japan round out that team.) In all, 15 different countries have worked to build the station since 1998, and more collaboration will be needed to make the next giant leap in space, Swanson and Wiseman said.

"Here on the International Space Station we are learning how to live and work in space for longer periods of time as we prepare for our next giant leap to explore an asteroid and visit Mars," Swanson added. "Like the station itself, those big missions will require the expertise and collaboration of many nations. We're privileged to be helping NASA move forward on that path."

Swanson commands an international crew of six astronauts aboard the space station. In addition to Swanson and Reid, the station crew includes Russian cosmonauts Oleg Artemyev, Alexander Skvortsov, Maxim Suraev and German astronaut Alexander Gerst.