Ceftiofur sodium

Ceftiofur sodium is a third generation cephalosporin antibiotic commonly used in veterinary medicine.

TOKU-E Company offers two forms of ceftiofur: Ceftiofur sodium (C061) and ceftiofur hydrochloride (C228). Ceftiofur sodium is freely soluble in aqueous solution, while ceftiofur hydrochloride is insoluble in water.

CAS Number

104010-37-9

Molecular Formula

C19H16N5NaO7S3

Molecular Weight

545.54 g/mol

Mechanism of Action

Like β-lactams, cephalosporins interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to cephalosporins is commonly due to cells containing plasmid encoded β-lactamases. Like many cephalosporins, ceftiofur is resistant to β-lactamases.