Villa Antonio Winery is a small, family operated winery in Jefferson County, approximately 30 minutes from south St. Louis County. The winery is situated in the scenic Sandy Valley area, and has a large patio and circa 1880s cabin from which to enjoy the view. The winery specializes in dry wines from French-American hybrid grapes.

The winery is owned and operated by the Polesel family. Antonio Polesel learned the art of winemaking from his father in the Veneto region of northern Italy.