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Novel Carboxylesterase Inhibitors (SJ-02-0030)

Technology Name
(St. Jude Reference #)

Novel Carboxylesterase Inhibitors (SJ-02-0030)

Description

Novel classes of compounds which have useful carboxylesterase inhibitory activity are provided, including both generic inhibitors, as well as compounds selective for the human intestinal carboxylesterase. These compounds can be used to treat or ameliorate the toxic effects of cancer therapy drugs (such as CPT-11), the effects of the drug overdose, or to increase the efficacy of existing insecticides and pesticides.