1Division of Neuropharmacology and Neurologic Diseases, Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia.2Division of Neuropharmacology and Neurologic Diseases, Emory University School of Medicine, Atlanta, Georgia.3Marcus Autism Center, Children's Healthcare of Atlanta, Department of Pediatrics, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia.4Division of Animal Resources, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia.5Division of Neuropharmacology and Neurologic Diseases, Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia;, Email: awchan@emory.edu.

刊名：

Comparative medicine, 2019, Vol.68 (2), pp.163-167

来源数据库：

PubMed Journal

原始语种摘要：

The neurodegeneration associated with Huntington disease (HD) leads to the onset of motor and cognitive impairment and their advancement with increased age in humans. In children at risk for HD, body measurement growth abnormalities include a reduction in BMI, weight, height, and head circumference. The transgenic HD NHP model was first reported in 2008, and progressive decline in cognitive behaviors and motor impairment have been reported. This study focuses on longitudinal body measurements in HD macaques from infancy through adulthood. The growth of HD macaques was assessed through head circumference, sagittal and transverse head, and crown-to-rump ('height') measurements and BMI. The animals were measured monthly from 0 to 72 mo of age and every 3 mo from 72 mo of age onward. A... mixed-effect model was used to assess subject-specific effects in our nonlinear serial data. Compared with WT controls, HD macaques displayed different developmental trajectories characterized by increased BMI, head circumference, and sagittal head measurements beginning around 40 mo of age. The physiologic comparability between NHP and humans underscores the translational utility of our HD macaques to evaluate growth and developmental patterns associated with HD.