Denamarin Chewable Tablets should be given on an empty stomach, at least one hour before a meal for optimal absorption. The number of chewable tablets administered may be gradually reduced, or increased, at
any time at the recommendation of your veterinarian.

For Dogs of All Sizes

Body Weight

Number of Chewable Tablets Per Day

Up to 6 lbs

¼

7-15 lbs

½

16-30 lbs

1

31-45 lbs

1 ½

46-60 lbs

2

61-75 lbs

2 ½

76-90 lbs

3

91-105 lbs

3 ½

Over 105 lbs

4

DENAMARIN Tablets



The #1 veterinarian recommended liver support brand
†



Two actives, one patented formula



Denamarin is a supplement for dogs and cats containing S-Adenosylmethionine (SAMe) and silybin

For optimal absorption, tablets should be given on an empty stomach, at least one hour before feeding, as the presence of food decreases the absorption of S-Adenosylmethionine. For those owners who have difficulty
administering tablets to their pets, Denamarin tablet(s) may be disguised in a small bite of food. If the pet is to receive more than one tablet daily, the total number of tablets may be divided between
morning and evening for ease of administration. For example, a daily administration of three tablets could be divided into two tablets in the morning and one tablet in the evening.

Denamarin can be used in conjunction with Marin
® Plus to provide additional silybin levels and the benefits of vitamin E, zinc, curcumin, and MCT oil supplementation. If Marin Plus is used in conjunction with Denamarin, the two products
should be administered 12 hours apart for best response.

Denamarin
® Advanced Chewable Tablets should be given on an empty stomach, at least one hour before a meal for optimal absorption. The number of chewable tablets administered may be gradually reduced,
or increased, at any time at the recommendation of your veterinarian.

Small to Medium Dog

Dog's Weight (lbs)

Number of Tablets Per Day

7-14

1/4

15-25

1/2

26-50

1

Large Dog

Dog's Weight (lbs)

Number of Tablets Per Day

51-85

1

86-130

1 ½

Over 130

2

† Source: Survey conducted among small animal veterinarians who recommended liver support
brands.

For optimal absorption, tablets should be given on an empty stomach, at least one hour before feeding, as the presence of food decreases the absorption of S-Adenosylmethionine. For those owners who have difficulty
administering tablets to their pets, Denamarin tablet(s) may be disguised in a small bite of food. Studies have shown that, in many cases, tablets or capsules given as a "dry swallow" do not pass into the stomach
in cats but may become lodged in the esophagus. It is recommended for pet owners to administer 3-6 cc of water immediately following any tablet administration to speed passage of the tablet into the stomach.
1, 2 Denamarin for Cats and Small Dogs tablets are ideal for cats because of their small size. If the pet is to receive more than one tablet daily, the
total number of tablets may be divided between morning and evening for ease of administration.

Veterinarian Portal

ABOUT
DENAMARIN

When liver function is compromised, the exact cause can often be difficult to determine. Supporting the liver, regardless of the cause, is essential to keep it working properly.

Administering
SAMe (S-Adenosylmethionine), which is found in Denamarin, has been shown to markedly increase liver levels of glutathione,
1, 2
an important compound for liver health formed when
SAMe is metabolized. The
SAMe in Denamarin has also been shown to help protect liver cells from cell death
3, 4 and may help cell repair and regeneration.
5

Denamarin also helps support your pet's liver through the administration of
SILYBIN.
SILYBIN is an active part of an extract from milk thistle, known as silymarin, and has been shown to support liver function by helping maintain a healthy oxidative balance.

While best known for supporting the liver in dogs and cats, research has shown that the S-Adenosylmethionine (SAMe) in Denamarin may help support cognitve function in dogs
6. Denamarin provides
SAMe in a stabilized form to help with brain health and act as a neuroprotector. Denamarin also provides a bioavailable form of
silybin which supports oxidative balance.

Denamarin has no known serious side-effects. Your veterinarian can evaluate the length of support needed through follow-up examinations, blood work, and/or other laboratory work. At home, watch for a reponse in your pet's attitude,
appetite, and activity level.

Denamarin is available as enteric-coated tablets for dogs and cats and in tasty chewable tablets for dogs. Advanced technology in the exclusive NMXSS75
® S-Adenosylmethionine found in the chewable formulation provides stability, eliminating the need for enteric coating or foil-on-foil blistering. The chewable tablets
for dogs are tasty, single size and scored for easy administration. Additionally, the chewable tablets allow for quicker uptake of the
SAMe and less variability between dogs when compared to enteric-coated tablets.

Denamarin is available from your veterinarian. Please consult your veterinarian to see if Denamarin is right for your pet.

Your veterinarian will advise you as to the amount to initially administer. Depending on your pet’s response and status, your veterinarian may eventually adjust this amount to meet your pet's individual needs.
Remember, Denamarin enteric-coated tablets should generally not be broken. When increasing or decreasing their administration, adjustments should be done in full tablet increments. Some pets are given Denamarin
only for a short period of time, while Denamarin may be used for longer periods of time in other animals.

Your veterinarian will likely recommend follow-up examinations, blood work, and/or other laboratory work to check on how well your pet is doing with Denamarin and how it may be helping to support your pet's
liver function. At home, watch for a response in attitude, appetite, and activity level.

Yes, your veterinarian may recommend combining Denamarin with other products, like Marin
® Plus in dogs, and/or dietary modifications. Combining Marin Plus with Denamarin in dogs provides added levels of silybin along with vitamin E, zinc, curcumin, and MCT oil for those patients
that may benefit from additional liver support. There are no known interactions of Denamarin with drugs or other supplements.

While other S-Adenosylmethionine and silybin products are available, there can be a significant variance in product quality and tablet strengths. Denamarin’s active ingredients individually have been shown to
be safe and effective for both dogs and cats in published research studies. Denamarin contains a specific silybin shown to provide better bioavailability in dogs compared to the standardized milk thistle
extract available in many other products.

SAMeIncreases levels of glutathione which is an important compound protecting
liver health.

SilybinThe silybin found in Denamarin and Marin Plus for dogs is complexed with
phosphatidylcholine which has been shown to increase absorption 4x
in dogs compared to standardized milk thistle extracts.

Vitamin EAn antioxidant that has been shown to help protect liver function.

ZincSupplementation may be beneficial in dogs with long-term decreased liver
function as these dogs often have low liver zinc levels. Zinc participates
in many enzymatic reactions within the body, and any deficiency may
have harmful effects. Zinc is not in Marin for Cats as deficiencies
have not been noted in cats.

CurcuminCurcumin has been shown to inhibit several mediators, supporting a healthy
inflammatory response. It also helps increase production of glutathione,
the liver's main antioxidant and “detoxifier” and protects against
fibrotic changes in the liver.

Medium Chain Triglyceride (MCT) OilIn the liver, MCTs can be used for energy for metabolic reactions. MCTs
can also help reduce fat deposition, which may occur in the liver
secondary to compromise.