With the aim to determine the role of inflammatory markers in stroke in our region, were collected data and blood samples from 104 patients between 45 and 92 years admitted with a diagnosis of stroke. It recorded death and morbility during 90 days of follow-up.
Was determined hsCRP as main inflammatory marker and also were determined IL-6, IL-10, neopterin and ICAM-1.
As main dependent variable was defined mortality throughout the follow-up period and death and morbility was the secondary dependent variable.
hsCRP, IL-6 and IL-10 showed significant differences in the bivariate analysis between groups of mortality and no-mortality, both as continuous variables or grouped by tertiles.
In the analysis of Cox regression, adjusted for age and sex, the hsCRP did not behave as independent marker of mortality at 90 days. Only IL-6 was significant, and remained as an independent factor in the model after entering cardiovascular history and major cardiovascular risk factors.
Bivariate analysis for variable mortality and morbility appeared only significant result for IL-6. Neither tertiles analysis, neither Cox regression was significant for biomarkers.
High levels of hsCRP, IL-6, neopterin and ICAM-1 and no elevation of IL-10 supports the idea of a proinflammatory mechanism after stroke.
This group had more death, cardiovascular history and risk factors, than other group in the same region with acute coronary syndrome (SIESTA Study).