↵bAnalyses stratified by weight loss percentage and using all available data (participants randomized to intervention arms with missing 12-month weight were classified as having no change/gained).

↵cP value obtained from GEE model comparing the difference in change of the biomarkers from baseline to 12-month in intervention group versus control within strata of percent weight loss, adjusted for age, baseline BMI (<30 kg/m2, ≥30 kg/m2), race/ethnicity (White, Black, and others), NSAID use, and statins use.

↵dP value obtained from GEE model testing the linear trend in the change of the biomarkers from baseline to 12-month from control through all levels of percent weight loss, adjusted for age, baseline BMI (<30 kg/m2, ≥30 kg/m2), race/ethnicity (White, Black, and others), NSAID use, and statins use.