A study from the University of California, La Jolla, California, USA shows that“Notch3signalingpromotesthedevelopmentofpulmonaryarterialhypertension.” This study was published in the 15 November 2009 issue of the journal “NatureMedicine”[the number 1 journal in General Medicine with an I.F of 28.054] byProf. Thistlethwaite PA, Li X and others.

What we say:

On the foundation of this interesting finding,Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD,reports that: Natural product therapy forpulmonaryarterialhypertension:Gallic acid (GA), isolated from Sumac, Gall Nuts, and Witch Hazel among others, inhibits the development of pulmonary arterial hypertension via down regulation of its target gene Notch3

Significance of the study:

Gallic acid (GA), by increasing the expression of its target gene,it may decrease the expression ofNotch3 (Fig.1).

Figure 1. Mechanistic insights into how Gallic acid inhibits the development of pulmonary hypertension via up regulation of its target gene

Thus, pharmacological formulations encompassing“Gallic acid (GA)or its analogues either alone or in combination with other drugs” may be usedtotreat pulmonary arterial hypertension.