@article{Sakaguchi2006ACP,
title={A carbohydrate-binding protein, Galectin-1, promotes proliferation of adult neural stem cells.},
author={Masanori Sakaguchi and Tetsuro Shingo and Takuya Shimazaki and Hirotaka James Okano and Mieko Shiwa and Satoru Ishibashi and Hideyuki Oguro and Mikiko Ninomiya and Toshihiko Kadoya and Hidenori Horie and Akira Shibuya and Hidehiro Mizusawa and Françoise Poirier and Hiromitsu Nakauchi and Kazunobu Sawamoto and Hideyuki Okano},
journal={Proceedings of the National Academy of Sciences of the United States of America},
year={2006},
volume={103 18},
pages={7112-7}
}

In the subventricular zone of the adult mammalian forebrain, neural stem cells (NSCs) reside and proliferate to generate young neurons. We screened factors that promoted the proliferation of NSCs in vitro by a recently developed proteomics technique, the ProteinChip system. In this screen, we identified a soluble carbohydrate-binding protein, Galectin-1, as a candidate. We show herein that Galectin-1 is expressed in a subset of slowly dividing subventricular zone astrocytes, which includes the… CONTINUE READING