Abstract

The aim of the present project is to study central action of melatonin (mainly in hypothalamus) and its interaction with leptin in the regulation of energy metabolism (energy intake and energy expenditure) (AU)

Abstract

Many hormones and neurotransmitters regulate feeding behavior. Leptin is in the spotlight since mutations in the genes encoding this hormone or its receptor resulted in severe obesity. Melatonin (Mel) is involved in the regulation of energy balance and its administration reduces food intake, body weight and abdominal fat in rodent models. In vitro, rhythmic Mel treatment synchronizes le...