Our lab is focused on addressing this basic question in the context of endocrine signaling. Endocrine hormones (such as estrogen) are secreted into the blood stream and affect cells that are at great distances from the hormone source. We are currently focusing on how estrogen interacts with local signals to regulate cancer cell behavior. Our lab uses a variety of high-throughput experimental methods to gather information about the cellular signaling network, and then employs computational models to interpret the data. Ultimately, we believe our models will be utilized to identify new drug targets and match patients to the most effective drugs for their individual tumor characteristics.

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The Kreeger lab utilizes systems biology and tissue engineering to analyze this question in the context of women’s health. We utilize an iterative approach, where we develop model culture systems that allow us to study these diseases in a controlled environment. We then use a variety of high-throughput experimental methods to gather information about the cellular signaling network and employ computational models to interpret the data. Ultimately, we believe our models will be utilized to identify new drug targets and match patients to the most effective drugs for their individual disease characteristics. Women’s health has historically been under-explored; thus, our research program offers a unique combination of innovative inter-disciplinary approaches in an urgent application area.

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Revision as of 17:54, 14 December 2010

How do cells respond to information from their surroundings and use this information to make decisions?

The Kreeger lab utilizes systems biology and tissue engineering to analyze this question in the context of women’s health. We utilize an iterative approach, where we develop model culture systems that allow us to study these diseases in a controlled environment. We then use a variety of high-throughput experimental methods to gather information about the cellular signaling network and employ computational models to interpret the data. Ultimately, we believe our models will be utilized to identify new drug targets and match patients to the most effective drugs for their individual disease characteristics. Women’s health has historically been under-explored; thus, our research program offers a unique combination of innovative inter-disciplinary approaches in an urgent application area.

The Kreeger lab is part of the Department of Biomedical Engineering at the University of Wisconsin-Madison. Our labs are located in the Engineering Centers Building.