A new species of the aspredinid catfish tribe Hoplomyzontini Micromyzon is described from two specimens collected with trawl nets in two localities, at 10 and 18 m depth, in the main channel of the lower Orinoco River in Venezuela almost 40 years ago. The new species is distinguished from its only congener, Micromyzon akamai, by the: straight anterior margin of the mesethmoid; open posterior cranial fontanel; ossified first pectoral-fin radial; single tubular infraorbital bone; infraorbital sensory canal entering neurocranium via the frontal; enclosed foramen for the abductor superficialis muscle in the coracoid; higher vertebral count (33 vs. 28–32); higher anal-fin ray count (10 or 11 vs. 7–9); and some morphometric features. The holotype of the new species was scanned using High-Resolution X-ray Computed Tomography to illustrate, describe, and compare its bony skeleton to other hoplomyzontins.