As a Surgical Oncologist and Hepatobiliary Surgeon, I believe in providing the highest quality, state of the art and compassionate care to patients with cancer or complex disease of the liver, pancreas, and bile ducts. (healthgrades.com)

In children, these abnormalities usually found in the neck and the axillary region, but they can present in other parts of the body such as mediastinum, pelvis, retroperitoneum as well as in solid organs (e.g., adrenal glands, pancreas, stomach). (readbyqxmd.com)

This is despite the fact that the tissue from which it arises - the pancreatic ductal epithelium - represents less than 10% of the pancreas by cell volume, because it constitutes only the ducts (an extensive but capillary-like duct-system fanning out) within the pancreas. (wikipedia.org)

The various kinds of cells that can give rise to NETs are present in endocrine glands and are also diffusely distributed throughout the body, most commonly Kulchitsky cells or similar enterochromaffin-like cells, that are relatively more common in the gastrointestinal and pulmonary systems. (wikipedia.org)

Although the cellular origin of NETs of the GI tract is uncertain, consistent expression of cytokeratins in NETs and the expression of the caudal-related homeodomain protein 2 (CdX2 protein), an intestinal transcription factor in endocrine tumors of the small intestine, suggests an origin from an epithelial precursor cell. (cancer.gov)

Most NETs of the small and large intestines occur sporadically, while others may occur within the background of an inherited neoplasia syndrome such as multiple endocrine neoplasia type 1 (MEN1) or neurofibromatosis type 1 (NF1) (e.g., gastrin-producing G-cell tumors and somatostatin-producing D-cell tumors of the duodenum, respectively). (cancer.gov)

Signs and symptoms of the most common form of pancreatic cancer may include yellow skin, abdominal or back pain, unexplained weight loss, light-colored stools, dark urine and loss of appetite. (wikipedia.org)

tuberin-hamartin complex functions as a tumor suppressor by suppression of the mTOR pathway.CNS lesions in TSC are the primary cause of mortality and morbidity and include cortical and cerebellar tubers, radial migration lines, subependymal nodules, and subependymal giant cell astrocytomas. (livermr.com)

von Hippel-Lindau disease (VHL) is an autosomal dominant disorder that results from germline mutations in the VHL tumor suppressor gene (chromosome 3p25) and is characterized by benign and malignant tumors in multiple organs.The VHL gene plays a pivotal role in the regulation of the intracellular oxygen-sensing pathway. (livermr.com)

Pancreatic cancer is usually diagnosed by a combination of medical imaging techniques such as ultrasound or computed tomography, blood tests, and examination of tissue samples (biopsy). (wikipedia.org)

The risk of developing pancreatic cancer is lower among non-smokers, and people who maintain a healthy weight and limit their consumption of red or processed meat. (wikipedia.org)

The exocrine group is dominated by pancreatic adenocarcinoma (variations of this name may add "invasive" and "ductal"), which is by far the most common type, representing about 85% of all pancreatic cancers. (wikipedia.org)

Symptoms such as abdominal or back pain or pressure, diarrhea, indigestion, or yellowing of the skin and whites of the eyes can arise from the effects of a larger PanNET tumor, either locally or at a metastasis. (wikipedia.org)

Computed tomography scan revealed an adrenal mass for which a right open transperitoneal adrenalectomy was performed, and the lesion was diagnosed as mature teratoma on histopathological examination. (readbyqxmd.com)

Patients must have a tissue diagnosis of any of the following metastatic, well or moderately differentiated, slow growing neuroendocrine tumor and must demonstrate progressive metastatic disease by prior serial computerized tomography (CT) or magnetic resonance imaging (MRI) scans, or have increased symptoms from their tumors while on sandostatin LAR or octreotide. (clinicaltrials.gov)

at five years from diagnosis, 65% of those diagnosed are living, though survival varies considerably depending on the type of tumor. (wikipedia.org)

Up to 60%[medical citation needed] of PanNETs are nonsecretory or nonfunctional, in which there is no secretion, or the quantity or type of products, such as pancreatic polypeptide (PPoma), chromogranin A, and neurotensin, do not cause a clinical syndrome although blood levels may be elevated. (wikipedia.org)

3 ] However, it is possible that the association may be due in part to the serendipitous discovery of slow-growing carcinoid tumors, which are found while staging or investigating symptoms from other tumors. (cancer.gov)

Although there are many kinds of NETs, they are treated as a group of tissue because the cells of these neoplasms share common features, such as looking similar, having special secretory granules, and often producing biogenic amines and polypeptide hormones. (wikipedia.org)