This essay aims to demonstrate the pretext of the struggle against illicit drugs as a justification to the U.S. military presence in the region by USSOUTHCOM that aims for ensure control of strategic resources in South America, in this case the freshwater. We will see in the midst of the crisis world and specifically in the United States because the Amazonas and Guaraní aquifer reserves represent spaces of geopolitical value. Colombia due to its geographical location is a geopolitical pivot, suitable territory within the framework of the geostrategy and geoeconomics in South America. On the other hand, american offensive conforms to resources wars: the new landscape of global conflict by Michael Klare.