Clinical Trials

Multicenter phase 2 study of transanal TME (taTME)

This surgical trial for patients diagnosed with resectable rectal cancer is studying the safety and efficacy of a new surgical procedure called low anterior resection with transanal total mesorectal excision (taTME). Transanal TME uses a “bottom-up approach” to overcome the technical difficulties of low pelvic dissection using an abdominal approach. Participants will undergo laparoscopic or robotic surgery.

This is a 5-year phase II multicenter single-arm study to evaluate the safety and efficacy of low anterior resection (LAR) with taTME using laparoscopic or robotic assistance in 100 eligible subjects with resectable rectal cancer. The researchers seek to determine if taTME is non-inferior to standard LAR with respect to the quality of the TME achieved.

Inclusion Criteria:

New diagnosis of histologically confirmed adenocarcinoma of the rectum