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Three-dimensional Electron Microscopy (3DEM) is becoming a key experimental method in Structural Biology. Recent advances in image acquisition and processing are yielding more structures determined at near-atomic resolution, as well as a wide range of macromolecular complexes and subcellular architectures determined at lower resolution.

A major goal of the EMDataResource team is to work with the 3DEM community to establish data validation methods that can be used in the structure determination process, define key indicators of a well-determined structure that should accompany every structure deposition, and implement appropriate validation procedures into a 3DEM validation pipeline. Following recommendations of the EM Validation Task Force (Henderson et al 2012), we are hosting new benchmark challenges here, with aim to stimulate further community discussions about validation procedures for 3DEM maps and map-derived models. Prior community-organized 3DEM challenge activities have included a Particle Picking Challenge (Zhu et al 2004), CryoEM Modeling Challenge (Ludtke et al 2012), CTF Challenge (Marabini et al 2015), and most recently, the Map and Model Cryo-EM Challenges (Lawson & Chiu 2018).

News

EMDataResource is trying something new and has put together a smaller, shorter-timeline EM model challenge. The deadline for submission of completed models fitted to target maps (2-3 Å resolution range) is May 25 May 28 (3 PM US Eastern). If you are interested in submitting models for this challenge please send us an email (challenges@emdataresource.org).

All of the articles that will appear in the Journal of Structural Biology Special Issue on the CryoEM Map and Model Challenges have now been accepted for publication and are either already online or will shortly appear there, as listed below. Click here or below for access. Many thanks to all who have contributed!

At the request of several Map Challenge participants we enabled submission of revised maps/info for 2016 Map Challenge entries in the period between mid-October 2017 and mid-January 2018. We offered this so that updated maps could be archived and referenced, e.g. as part of a contribution to the planned journal special issue.