A mouse model of TBI could
be useful for studying inflammatory mechanisms in the disease and screening
for potential treatments. To mimic TBI, mice underwent surgical thinning and
compression of the skull. Transcranial imaging of the injury site revealed
proinflammatory innate immune activity and apoptosis. Local administration of
purinergic receptor antagonists showed that acute inflammation protects
against cell death. Next steps include identifying and testing drug
candidates that modulate inflammatory response and cell death in the model.

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