I have been taking Levo thyroxine now for a few years and always had taken when I woke up before eating.

I had read some information where people had found that taking it at night worked better for them, so decided to try this. The last couple of days I have had a massive energy dip at around 17.00 / 18.00 and just needed to sleep.

So just wondered has anyone else experienced this? When taking at night it was around midnight I took the tablet (100 mg).

Thanks Flower - guess it did not work for me so am going back to mornings. Will be seeing Endo again in the next weeks so will see what my results are and see if there is a reason maybe there for me having big dips in energy.

I take levothyroxine in late afternoon, at 5:00 - 6:00pm every day. Works great for me. No weight gain nor interference with sleep nor energy dips. Everyone is different and therefore reacts differently to meds.