For the first time a sequence of DNA present in around two-thirds of the most common tumour has been pinpointed.

Pilocytic astrocytomas is diagnosed in 145 children from five to 19 every year, with nearly 40 cases untreatable.

As little is known about the causes and genetics of brain tumours, it is hoped the findings could lead to better treatment.

Professor Peter Collins, who led the research at Cambridge University, carried out genetic scans on 44 pilocytic astrocytoma and found a DNA sequence rearranged on a chromosome in the majority of the samples.

We think this important finding will be vital in guiding our future research

Dr Lesley Walker

The rearrangement creates a fusion gene, a hybrid created from two separate genes.

It is the first time fusion activity has been associated with a brain tumour.

Professor Collins said: "If we can diagnose exactly which type of brain tumour a child has as early as possible, the tumour is more likely to be treated successfully.

"We also hope the findings will mean it is possible to create therapies in the future that block the activity of the fusion gene and halt the growth of tumour cells."

Dr Lesley Walker from Cancer Research UK said: "Any discovery that adds to our understanding of the pathways that cause these tumours to form is quite exciting news.

"We think this important finding will be vital in guiding our future research."

WEEP News

by: Martin Weatherall

As a Canadian independent foundation, WEEP acts as an umbrella organization and focuses on progressive initiatives that bring increased awareness, policy change, and entrepreneurial activity around the issues of safe Electro Magnetic emissions.

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