1. - If triggers don't work after installing Mavericks/Yosemite/El Capitan/Sierra/High Sierra/Mojave:In Mavericks/Yosemite/El Capitan/Sierra/High Sierra/Mojave the location QuicKeys refers to and takes you to for setting up Accessibility has changed from the Accessibility pane to the Security & Privacy pane. So in System Preferences change to the Security & Privacy pane. Switch to the Privacy tab and pick Accessibility in the left column. Check both QuicKeys and QuicKeysUserEventHelper. Quit and restart QuicKeys.

Note: If items are grayed out in the list then you need to click the Lock icon in the lower left corner and supply your password.2. - Yosemite/El Capitan/Sierra/High Sierra/Mojave - additional steps for adding QuicKeysUserEventHelper:For some reason the QuicKeysUserEventHelper isn't always showing up in the above window. To manually add it do the following and use the figure below for reference:leaving the Security & Privacy pane open go to the Finder and open the Applications folder and in that Finder window locate the QuicKeys application and right-click or control-click it and select Show Package Contents from the contextual menu. Open the Contents folder and then the Resources folder. Then in this Finder window type into the top right search field .app and several applications will be displayed. Make sure the Search location has "Resources" selected and not "This Mac" or you will get all your applications and QuickeysUserEventHelper will not show up. Drag QuicKeysUserEventHelper into the System Preferences window where QuicKeys is and you should get an insertion line in the list and QuicKeysUserEventHelper should get a green plus. When you get those two things release it and it should be added to the list. If it still doesn't show up when you drop it on the list then it was already in the list but the OS isn't wanting to show it. Just quit and restart QuicKeys and it should work even if it isn't showing.

3. - If triggers are working intermittently:In the Finder go into the Applications folder and click on QuicKeys once (do not double click and open it) and do a Get Info (command-I) and check Prevent App Nap. Quit and restart QuicKeys.NOTE: If you are ever directed by Support to access something that belongs to QuicKeys such as its preferences or shortcuts in your Home/Library/ folder you need to hold down the option when you select the Go menu in the Finder and Library will show up for you to select it.

4. - How to check that Prevent App Nap is working when it is checked and triggers are still working intermittently:

I now have a fix that worked for me from working with Startly Support. QuicKeys kept napping even though I had "Prevent App Nap" checked in the Get Info window. If hitting the QuicKeys menu as I described above makes it work for a short time, as it did for me, this fix should work for you, too.

The short story is you need to restart QuicKeys after checking "Prevent App Nap" or the change is not remembered.

First, make sure you have done the Accessibility settings found in Security & Privacy preferences as described above by gb2.

Then, verify you have the same problem I had:

open Activity Monitor found in your Applications folder and then inside the Utilities folderSelect View menu > Columns > App Nap (this will add a column to the output that shows if an app is asleep)There is a small search field on the top right corner of the Activity Monitor window. Type "QuicKeys" (without quotes) in that field. Now you should see only QuicKeys processes. Does the QuicKeys app show "Yes" in the nap column? If it does not, wait several minutes (or until QuicKeys stops working) then check again.If it does say "Yes," then do the following:Go to Applications folder and find the QuicKeys app. Right click on it and select "Get Info." Make sure "Prevent App Nap" is checked.Open QuicKeys, then quit QuicKeys. (Don't quit QuicKeys from the Dock, although I suspect that doesn't matter. It's just the way I did it.)Restart QuicKeysYou should notice in Activity Monitor that QuicKeys will never show "Yes" in the App Nap column again and QuicKeys will run reliably again.

Thanks aManHasSaid for the tip - did EXACTLY what was suggested on both office and home computer (MacBookPro Retina w/SSD and 10.9) - but QK on both computer still had a bad case of narcolepsy!! Grrrrrr! Eventually discovered TWO apps in the app folder. One was QuicKeys.app and the other QuicKeys4.app and surprise - both had the same info pane creation date, version# etc. l Don't have any idea how that happened. Trashed QuicKeys.app and restarted - and now QK has been working like a charm.

Soooooooo if you have done all that was suggested and QK still nods off even though you are SURE 2 copies could NOT be on your computer I suggest checking for a 2nd copy anyway.

6. - If shortcuts that deal with Windows and Menu Selections are not working or you get Hot keys cannot be assigned or used:

if it appears that Accessibility isn't working even though you have both QuicKeys and QuickeysUserEventHelper added and checked as shown above do the following:Go to the QuicKeys preferences General tab and at the bottom under Reset "Do Not Show Again" Messages click the Reset button. Quit and restart QuicKeys and you should be presented with a dialog saying Accessibility is not enabled for QuicKeys. In the Accessibility settings window remove both QuicKeys and QuickeysUserEventHelper from the list by using the minus button below the list and then add them back in then quit and restart QuicKeys. Under some extreme conditions the OS may still not recognize that accessibility is still setup correctly when it looks correct in the list. In that case try removing QuicKeys and emptying the Trash and restarting your machine. Download a fresh copy and go through the procedures again from above.

After updating the OS from say 10.11.3 to 10.11.4 your shortcuts no longer trigger you need to go back and check the Accessibility settings from above. For some reason minor OS updates have been randomly unchecking QuicKeys and QuicKeysUserEventHelper in the System Preferences Security & Privacy pane under Accessibility.

the above is all you need to make QuicKeys triggers work in Mavericks/Yosemite/El Capitan/Sierra/High Sierra/Mojave. If you think you have followed the above and still can't get triggers to work then use the following link to Contact Support, explaining what you have tried.