United, entering the tournament in the second round for the first time in 19 years, will face Karl Robinson's League One outfit , after they beat AFC Wimbledon in their first round clash on Tuesday evening.

It will be Louis van Gaal's first competitive cup match in charge of the Red Devils, following his appointment as manager.

Elsewhere, Gus Poyet's Sunderland will travel to St Andrews to face Championship side Birmingham, whilst Sheffield United meet West Ham in a match which continues to bare bad blood following the Carlos Tevez saga.

Ronald Koeman will take his Southampton side to Millwall, while Russell Slade's Leyton Orient head to Villa Park to face Premier League Aston Villa.