Reactivity Notes

Human and mouse.

Packaging, Storage & Formulations

Storage

Store at 4C in the dark.

Buffer

50mM Sodium Borate

Preservative

0.05% Sodium Azide

Purity

Immunogen affinity purified

Notes

Dylight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for BTK [p Tyr223] Antibody [DyLight 650]

Agammaglobulinaemia tyrosine kinase

AGMX1

AGMX1MGC126262

AT

ATKIMD1

B-cell progenitor kinase

BPK

Bruton agammaglobulinemia tyrosine kinase

Bruton tyrosine kinase

BTK

dominant-negative kinase-deficient Brutons tyrosine kinase

EC 2.7.10

EC 2.7.10.2

IMD1

PSCTK1

tyrosine-protein kinase BTK

XLA

XLAMGC126261

Background

Bruton's tyrosine kinase (BTK) takes part in B-cell ontogeny, differentiation, and signaling. A kinase member of the Tec family, it's signaling leads to cytoskeletal changes, as well as calcium, NF kappa B, and NFAT signaling. Defects in the gene cause X-linked agammaglobulinemia (XLA). Autophosphorylation can occur on Tyr-223 and Tyr-551. pY223 activates the protein that is inhibited by IBTK, and creates a docking site for SH2 domain proteins.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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