This new bioink kit allows users with an Allevi 2, Allevi 3 or Allevi 6 to mix materials from two syringes during the printing process. This is especially useful when working with materials that require curing catalysts or liquid crosslinking agents (i.e. sodium alginate, calcium chloride, certain silicones, etc).

The ability to mix materials at the nozzle opens up a whole new frontier of materials that you are able to extrude from your Allevi bioprinter. The Coaxial Kit is prepackaged with everything you need to get started out of the box including coaxial tip, tubing, luer lock tip connectors, and custom coaxial gcode.

Our mission here at Allevi is to supply you with best possible bioprinting tools that make it easy to bring your work to life. We are constantly testing new methods, bioinks, and tools in our lab to ensure that we are delivering cutting edge techniques to your bench. Together we are making giant strides in the field of tissue engineering and uncovering new methods that will forever change the way we #buildwithlife. We can’t wait to see what you will build with this one.

One of the challenges within tissue engineering is creating thick tissues. Why is that? To date it has been challenging to add vascularization to 3D printed tissues.

Vascularization is our body's highway system. Networks of veins reach each cell to deliver fresh oxygen and nutrients, and remove waste and carbon dioxide. This vascular network is essential for organ function.

The challenge within tissue engineering has been to replicate these networks, but even more so… to design them. We have been limited in our bioprinted tissue's thickness because it has been difficult to create these highways in the lab. ....Until now.

We are excited to launch the Allevi Vascularization Kit that empowers you to replicate some of the most complex vascular trees in an easy way. It enables you to create cm thick tissues in an automated, standardized fashion and allows your thick tissues to live for weeks.

Vascularization is foundational to begin studying, and replicating the body outside the body in a more accurate way. We are excited to provide you with a cornerstone application within the Allevi platform to help you find solutions to humanity's most difficult problems.

Gelatin Methacrylate (GelMA) is a popular material in bioprinting due to its mechanical properties and printability. However, the process of methacrylating gelatin and sterile filtering it is time-consuming, cumbersome, and inefficient.

We know how annoying it can be! So after months of testing - we're excited to release our new pre-sterilized and pre-loaded GelMA that is ready to be mixed with your cell suspensions and photo-initiators.

No more filtering. No more lost product. No more measuring. Just add your cells and start printing!

In their paper titled, “Agarose-Based Hydrogels as Suitable Bioprinting Materials for Tissue Engineering” and published in ACS Biomaterials Science & Engineering, they compared agarose-based hydrogels commonly used for cartilage tissue engineering to Pluronic. The goal is to find a bioink that has great printability without sacrificing cell viability.

There are so many variables that go into creating viable 3d bioprinted tissues; bioink selection, print geometry, cure times, rigidity, flexibility, degradation time and cell viability to name a few. Not to mention, each of these parameters needs to be analyzed and perfected for every cell line in the body. As a community, we are still figuring out the perfect protocol for each organ system.

In a new paper out this week titled “A Comparative Study of a 3D Bioprinted Gelatin-Based Lattice and Rectangular-Sheet Structures”, our newest Allevi Authors tackled one of these lingering questions, “What is the best print structure for cardiac tissue, lattice or sheet?”

Researchers at University of Texas El Paso and University of Texas at Austin used their Allevi 2 bioprinter and furfuryl gelatin to study and compare 3d bioprinted lattices vs sheets. Through their comparison, they discovered that the lattice structure was more porous with enhanced rheological properties and exhibited a lower degradation rate compared to the rectangular-sheet.

Further, the lattice allowed cells to proliferate to a greater extent compared to the rectangular-sheet. All of these results collectively affirmed that the lattice poses as a superior scaffold design for tissue engineering applications.

We’re #bioprinting with the #Allevi1 today in our lab. We’re using the #autocalibration feature to quickly switch between syringe tips, printing into #wellplates for #highthroughput, using the cooling feature to work with #collagen, AND we’re controlling it all remotely using the Allevi software to reduce the risk of contamination.
All this powerful tech in such a small footprint means we have space to spare under our hood! We design our #bioprinters around your workflow because we know how precious space and time are when it comes to the lab. What will you build?
#bigimpact #smallfootprint #bioprint #buildwithlife #mindfuldesign #customerfeedback #biotech #pharma #tissueengineering

Okay okay not the heart you were imagining today but we wanted to take a moment to tell you about how cool heart tissue is!
Heart tissue is composed of two main cell types- cardiomyocytes (CMCs) and cardiac fibroblasts (CFBs). CMCs are the contracting cells which allow the heart to pump. Each CMC needs to contract in sync with its neighboring cells to efficiently pump blood from the heart to the rest of your body. CFBs give support to the muscle tissue but are unable to provide forceful contractions. They hold the CMCs in place so they can do their job. Don’t discount CFBs though- they play a crucial role in responding to injury by creating collagen to repair broken tissue.
Our newest addition to the #AlleviAuthor club is a team of researchers out of @gwuniversity that is #3D #bioprinting heart tissue!! Read more at the Allevi blog and Happy Valentine’s day!

We are so honored to be selected by FierceMedTech as one of their #Fierce15 MedTech Companies of 2018! What really makes Allevi #fierce is our amazing #community of users who are using their Allevi #bioprinters to make tangible impacts on patients’ lives. #buildwithlife #healwithlife Thank you, FierceMedTech!!
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#medtech #biotech #bioprint #3d #bioprinter #futureofmedicine