❖Pharmacodynamics Suppresses products in the stomach of hydrochloric acid by the action of a proton pump on gastric cells. The active substance is transformed into the active form in the channels of the walls of the parietal cells and blocks the enzyme H-K-ATP-azu, that is, at the final stage of the synthesis of hydrochloric acid. In most patients, relief of symptoms occurs after 2 weeks of therapy. Like other proton pump blockers and H2-type receptors, drug therapy causes a decrease in acidity and an increase in gastrin content.

❖PharmacokineticsPantoprazole is actively absorbed, the highest concentration in the blood is achieved after a single dose. On average, the highest concentration in the blood occurs 2.5 hours after application.

⌚The half-life is about an hour. There have been a number of cases of delayed withdrawal.

Reaction with plasma proteins approaches 98%. The original drug is almost completely transformed in the liver.

The kidneys excrete about 80% of the metabolites, the rest is excreted in the feces. The main metabolite is desmethyl-pantoprazole, its half-life is approximately 1.5 hours.

Pantoprazole tablets must not be chewed or broken, they must be swallowed whole, taken before meals and washed down with water.

In the treatment of mild reflux disease and associated symptoms (acid regurgitation, heartburn, pain when swallowing) the recommended initial dose is 20 mg per day. Improvement is achieved after about 2-4 weeks, for the treatment of esophagitis, which appeared on the background of the disease usually need monthly therapy. If the specified time period is insufficient, recovery occurs within the next month. Recurrence of the disease is controlled by consuming 20 mg of Pantoprazole once a day, if necessary. If acceptable symptom control cannot be maintained in this way, it is allowed to consider switching to permanent therapy.

With prolonged treatment of reflux esophagitis, a maintenance dosage of 20 mg per day is recommended. In case of frequent relapses, the dosage is increased to 40 mg per day. After stopping the symptoms of relapse, the dosage can again be reduced to 20 mg per day.

For the prevention of peptic ulcer disease induced by non-steroidal anti-inflammatory drugs, the recommended dosage for people with risk factors is 20 mg of the drug per day.

In the elderly and patients with kidney failure, the daily dosage of Pantoprazole should not be higher than 40 mg.

Patients with severe liver failure should not exceed the dosage of Pantoprazole 20 mg per day. These patients during the period of therapy should be determined by the content of liver enzymes. If their concentration begins to increase, pantoprazole therapy must be canceled.

❖Overdose Cases of overdose should be treated according to the standard practice of treatment of toxic conditions.

The use of proton pump blockers is prohibited during treatment with Atazanavir.

The drug is metabolized in the liver under the influence of cytochrome P450, however, significant interactions with Diazepam, Carbamazipyrin, Caffeine, Diclofenac, ethanol, Digoxin, Glibenclamide, Naproxen, Metoprolol, Nifedipine, Piroksikam, Teofillin, a draphotoxorset, a teofillin, a headset, a tefillin, a draped body, a teofillin, a draped body, a teofillin, a tefillino, a tefillinom, a tefillinom, a tefillinom, a tefillinom, a tefillinom, a tefillinom, a tefillinom, tefillinom, tefillinoma

If the patient uses coumarin anticoagulants, it is recommended to measure the prothrombin period and the INR value during and after pantoprazole treatment.

❖Storage conditions Keep out of the reach of children. Store at temperatures up to 25 degrees.

❖Shelf life 3 years.

❖Special instructions Persons with severe liver failure in the treatment with pantoprazole are recommended to regularly measure the content of liver enzymes. In case of an increase in the level of liver enzymes, therapy should be discontinued. The use of Pantoprazole 20 mg tablets to prevent the appearance of gastric and duodenal ulcers induced by nonsteroidal anti-inflammatory drugs is indicated for patients who need long-term use of NSAIDs and have an increased risk of developing complications from the digestive system.

With low acidity, the number of bacteria present in the gastrointestinal tract, as a rule, grows. Therefore, therapy with drugs that reduce acidity, can lead to a weak increase in the risk of gastrointestinal infections.

Pantoprazole is able to lower the absorption of vitamin B12 as a result of hypochlorhydria or achlorhydria.

Before treatment, it is necessary to exclude the presence of malignant tumors of the esophagus or stomach, since treatment with Pantoprazole may mask the symptoms of such diseases and lead to their late diagnosis.

❖For children Not applicable in children under 12 years.

❖During pregnancy and lactation The drug is prohibited to use during lactation.

Use during pregnancy is possible only under strict indications.

❖Reviews Reviews of the drug characterize it as an effective and inexpensive drug for the treatment of peptic ulcer and GERD. Side effects occur infrequently, while respecting the reception regimen.

Delivery and service – customer feedback

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Why are drugs in online pharmacies cheaper than in real ones?

⚠First of all, when buying drugs, consumers pay attention to the price. If it suits you can safely buy. But many start-up Internet users are scared off by low (compared to the usual pharmacies) the cost of medicines that are sold online. It is difficult to understand, not knowing all the intricacies, why buying an online drug is much cheaper than around the corner of your house.
Why so cheap?
Sale on the Internet does not require such material investments as trade in reality. Owners of ordinary pharmacies are forced to pay for renting premises, the work of pharmacists, sellers, cleaners. On the Internet, drugs are sold cheaper, because the creators of online stores do not make unnecessary extra charges. In addition, many sellers today deliver products directly to the house or offer to pick up at the nearest pharmacy.
Discounts for regular customers, including savings, are a common practice in the network. If you buy regularly, then it is beneficial for you to cooperate with a certain pharmacy. So your discount will grow to the maximum level, and the saved money can be spent for personal development, travel, gifts or a favorite hobby.

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