disrupt nerve impulse transmission at the level of internuncial neurons of spinal cord, brain stem, and subcortical areas of the brain--> skeletal muscle relaxation and little to no sedation

What are the cardiac effects of Guaifenesin?

minimal

What are the respiratory effects of Guaifenesin?

minimal respiratory depression

Neuromuscular blocking drugs are used to _____________; the prototypical drug in this category is ___________.

skeletal muscle paralysis; curare

Neuromuscular blocking drugs DO NOT produce...

unconsciousness, sedation, or analgesia

Describe the physiology of the neuromuscular junction.

Ach is synthesized from choline and acetate in the presence of Ach transferase--> Ach is released from nerve endings in response to impulse traveling down a motor nerve--> Ca2+ enters the nerve terminal, combines with calmodulin, and facilitates the d/ of Ach--> Ach stimulates nicotinic cholinergic receptors on skeletal muscle membrane to initiation excitation-contraction coupling--> Ach hydrolyzed by acetylcholinesterase