Previous GeneCards Identifiers for CAPZB Gene

Summaries for CAPZB Gene

Entrez Gene Summary for CAPZB Gene

This gene encodes the beta subunit of the barbed-end actin binding protein, which belongs to the F-actin capping protein family. The capping protein is a heterodimeric actin capping protein that blocks actin filament assembly and disassembly at the fast growing (barbed) filament ends and functions in regulating actin filament dynamics as well as in stabilizing actin filament lengths in muscle and nonmuscle cells. A pseudogene of this gene is located on the long arm of chromosome 2. Multiple alternatively spliced transcript variants encoding different isoforms have been found.[provided by RefSeq, Aug 2013]

UniProtKB/Swiss-Prot for CAPZB Gene

F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Plays a role in the regulation of cell morphology and cytoskeletal organization.

Function for CAPZB Gene

Products:

Molecular function for CAPZB Gene

F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Plays a role in the regulation of cell morphology and cytoskeletal organization.

No data available for
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery ,
Protein differential expression in normal tissues ,
mRNA Expression by UniProt/SwissProt and
Phenotype-based relationships between genes and organs from Gene ORGANizer
for CAPZB Gene