Medical Journal of the Islamic Republic Of Iran http://mjiri.iums.ac.ir
Medical Journal of The Islamic Republic of Iran (MJIRI) - Journal articles for year 1995, Volume 8, Number 4Yektaweb Collection - http://www.yektaweb.comen1995/2/12CARCINOMA OF THE ESOPHAGUS IN A FOURTEEN YEAR OLD BOYhttp://mjiri.iums.ac.ir/browse.php?a_id=1370&sid=1&slc_lang=en
This is the first documented case of esophageal carcinoma in a 14 year old
boy which has been reported to date. Carcinoma of the esophagus is rare
before the third decade. The present case highlights the fact that the condition
should be kept in mind in the differential diagnosis of progressive
dysphagia even in children and teenagers
MANOOCHEHR M. LARIMANDIBULAR OSTEOSARCOMA MISTAKEN FOR PERICORONAL INFECTION A CASE REPORThttp://mjiri.iums.ac.ir/browse.php?a_id=1369&sid=1&slc_lang=en
Osteosarcoma is relatively rare in the jaws and variable in presentation, thus
its recognition may be quite confusing and delay diagnosis and treatment. Also, in
contrast to most malignancies, osteosarcoma is usually encountered earlier in life
and may clinically resemble features of more common oral entities such as chronic
osteomyelitis, fibrous dysplasia, osteoblastic metastatic carcinoma, ossifying
subperiosteal hematoma and chondrosarcoma. Hence definitive treatment may be
inadvertently delayed, jeopardizing the chance for cure.
A case of chondroblastic osteosarcoma of the mandible which was mistakenly
treated as a pericoronal infection by a dentist is presented. The treatment instituted
was continued for several weeks despite progression of the lesion, after which the
patient was referred. This delay made necessary a more radical resection than that
which would have been needed had the patient been referred earlier.
MOHAMMAD HOSEIN KALANTAR MOTAMEDISUBCU TANEOUS FASCIOLIASIS: A RARE COMPLICATIONhttp://mjiri.iums.ac.ir/browse.php?a_id=1368&sid=1&slc_lang=en
A case of ectopic fascioliasis due to migration of an immature Fasciola
hepatica fluke is described in a 23 year old woman from western Iran.
MOHSEN EMAMI AL-AGHAISLAMIC MEDICAL JURISP RUDENCE PART II: THE RESPONSES OF ISLAMIC LAW TO MEDICAL DILEMMAShttp://mjiri.iums.ac.ir/browse.php?a_id=1367&sid=1&slc_lang=en
Judicial decisions (Fatawa) of some of the most learned juridical authorities
in the Imamate (Shiite) community (maraja' al-taqlid) of present time on medical
issues are examined in this paper. They will provide the reader with the responses
of the Islamic jurisprudence to the most involved medical dilemmas. The paper
mainly focuses on the rational viewpoints of the Islamic law on permission of
family planning and birth control, strict ban of abortion especially when the
embryo is four months and above in normal conditions, and legitimacy of artificial
insemination by the husband. Judicial prescription of cadaver and organ donation
and transplantation are also discussed in some detail. The religious rite of
circumcision and its impac! on the health of man is duly elaborated and the
principles of medical examination explained. The principle of priority of saving
human life prevails all forbidden rulings set out for observing human sanctity in
ordinary cases. Also, the principle of necessity when no definitive ruling is
available on a given issue, has been an important source for religious prescription
in all matters pertaining to the welfare of the Muslim society.
SEYYED MOHAMMAD TAGHI AYATOLLAHlAXENIC CULTURE AND CRYOPRESERVATION OF GIARDIA LAMBLIA ISOLATED IN IRANhttp://mjiri.iums.ac.ir/browse.php?a_id=1366&sid=1&slc_lang=en
Giardia lamblia cysts were isolated from fecal samples of 55 symptomatic
and asymptomatic patients with giardiasis. The cysts were harvested and purified
using the sucrose gradient method. IS The excystation of G. lamblia was obtained
by treating them with HCI (0.01N)', then they were transferred on to modified
TYI-S-33 medium. Out of 55 stool samples 17 cases were excysted with a rate of
4-32%,but we were able to cultivate only one case with 12% excystation in culture
medium. The generation time of G.lamblia was calculated to be about 10.33 hours.
Cryopreservation of trophozoites was successfully done in liquid nitrogen
and the thawing process had a survival rate of 85-90%.
M REZAIANTHE EFFECT OF THEOPHYLLINE ON THE KINETICS OF cAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT, cAMP, PROTEIN KINASE INHIBITOR AND THEIR RELATIONSHIP IN LUNG TISSUEhttp://mjiri.iums.ac.ir/browse.php?a_id=1365&sid=1&slc_lang=en
We have investigated the effect of theophylline on the kinetics of the catalytic
subunit of protein kinase and related factors in lung tissue. The results show that
the point of highest concentration of the C subunit of protein kinase which is active
in casein phosphorylation is at 3h of incubation time, but in the presence of 100 Ilg/
InL and 10µg/mL theophylline, this is shifted to I.S and 2.S hrs, respectively. Also
the maximum concentration of cAMP for the control is at 2.S h of incubation time,
butin the treated samples shifts to 2.15 and LIS hrs, respectively. Inhibitor protein
content also changes considerably in the presence of 10µg/mL theophylline. The
results suggest an effect of theophylline on the function of cAMP-dependent
protein kinase.
MASSOUD BOOJARDEVELOPMENT OF A SIMPLE AND SENSITIVE ENZYME- LINKED IMMUNOSORBENT ASSAY (ELISA) FOR CLINICAL MEASUREMENT OF TESTOSTERONE USING PENICILLINASE AS LABELhttp://mjiri.iums.ac.ir/browse.php?a_id=1364&sid=1&slc_lang=en
An enzyme-linked immunosorbent assay using a homologous combination of
antiserum raised against testosterone-3-0-carboxymethyloxime-bovine serum albumin
(T-3-0-CMO-BSA ) and penicillinase-labelled T-3-0-CMO was developed.
This assay was utilized to measure testosterone in serum samples of male and female
subjects. The sensitivity of the assay is 50pg/well and the antibody developed crossreacted
in less than 20% with 5α-dehydrotestosterone (5α DHT) . lnter- and
intraassay variations and all other validation factors such as recovery, test of
parallelism, etc. were well in the acceptable ranges. Comparison of testosterone
values of 32 plasma specimens obtained by solid phase ELISA method and
radioimmunoassay (RIA) showed a good correlation (0. 96).
GHR ASADY KARAMCOMPARISON OF GROWTH CHARTS OF 1-36 MONTH OLD TEHRANI CHILDREN WITH THE N.C.H.S.l CURVEhttp://mjiri.iums.ac.ir/browse.php?a_id=1363&sid=1&slc_lang=en
During a historic prospective study, measurements of weight, height and head
circumferences were carried out in a group of 393 Tehrani boys and girls between
the first and 36th month of life and measurements were plotted over the N.C.H.S.
curves. These children belonged to middle and high-class literate families who
were able to understand and follow the medical advice given by their private
pediatricians.
Results of this study (Table I and Figs. 1-6) indicate that the trend of growth
of this sample of middle and high-class Tehrani children does not differ from
N.C.H.S. standards, provided that the parents understand and follow the instructions
given with regards to diet, timing, and type of introduction of foods as well as
hygienic and preventive measures to be taken.
MOHAMMAD ALI NILFOROUSHANTHERAPEUTIC EVALUATION OF INTRALESIONAL INJECTION OF BLEOMYCIN SULFAT E IN THE TREATMENT OF RESISTANT WARTShttp://mjiri.iums.ac.ir/browse.php?a_id=1362&sid=1&slc_lang=en
From June 1992 to March 1993, a group of patients suffering from
different types of warts were treated with intralesional injections of
bleomycin sulfate.
This study reviews the literature concerning this modality of treatment
and the pathophysiology and immunohistopathology of warts and options for
treatment.
In this prospective study, a combination of a I mg/mL solution of
bleomycin in distilled water and lidocaine 2% (in equal portions) was injected
in 22 patients. No patient received more than 2mL of the solution.
Eighty-four of 95 warts (88.4%) showed complete resolution after 1-3
bleomycin injections, while 10 warts (10.5%) showed incomplete resolution.
In only one plantar wart did bleomycin fail to elicit any therapeutic response
(1.1%).The cure rate was 96.3% for periungual warts, 84.6% for
palmoplantar warts, and 75% for warts located on the extremities. The responsive
warts developed a hemorrhagic eschar that healed without scarring.
No systemic side-effects were observed but a mild transient pigmentary
change was seen at the injection site of one palmar wart.
It is concluded that this form of treatment for resistant warts is safe,
reliable and well accepted by the patients if used in the dose mentioned.
JAVAD GOLCHAIPHARMA COKINETICS OF RECOMBINANT ERYTHROPOIETIN AND RED CELL METABOLISM IN HAEMODIALYSIS PATIENTShttp://mjiri.iums.ac.ir/browse.php?a_id=1361&sid=1&slc_lang=en
The pharmacokinetics of recombinant human erythropoietin (rHuEpo)
administered intravenously has been investigated in a group of five patients with
chronic renal failure who were dialysis-dependent. The half-life of circulating
erythropoietin decreased from 7.9±OA hr (mean ±SO) at the beginning of treatment
to 6.2±O.6 hr after 6 weeks and 5A±O.9 hr after 4 months of treatment. In spite of the
sustained increase in haemoglobin neither the red ce1l2,3,-diphosphoglycerate (2,3-
DPO) nor the P50 decreased from the pretreatment values. The mechanism which
governs the rise in 2,3-diphosphoglycerate in chronic renal failure is different from
the adaptive mechanism which operates in other types of anaemia.
MORTEZA AFRASIABIIS THERE ANY RELATION BE TWEEN ESTROGEN LEVEL AND P OOR CERVICAL MUCUS IN PA TIEN TS RECEIVING CLOMIPHENE CITRATE?http://mjiri.iums.ac.ir/browse.php?a_id=1359&sid=1&slc_lang=en
Clomiphene citrate (CC) has an adverse effect on the quality and quantity
of cervical mucus (CM). Poor cervical mucus has been reported in 15%
of CC-treated women. CC exhibits estrogen agonist and antagonist activities.
Antiestrogenic activity affecting the endocervical glands is theorized to
cause a decrease in cervical mucus quality and quantity. An experimental
study was performed to assess if there is any relation between poor CM and
the level of estrogen in those to whom the drug is administered. We used CC
on 50 subjects and evaluated CM and measured serum E2 levels simultaneously.
We concluded that there is no relation between the level of estrogen
and the quality or quantity of CM in these patients.
SAElDEH ZIAEIINFECTIVE ENDOCARDITIS IN CHILDRENhttp://mjiri.iums.ac.ir/browse.php?a_id=1358&sid=1&slc_lang=en
A total of 14 cases of infective endocarditis (IE) in children aged 6
months to 10 years were seen from December 1987 to December 1992 at the
pediatric unit of Ayatollah Taleghani Medical Center. The majority of patients
(12 of 14) were between 5 and 10 years of age. Acyanotic congenital
heart disease was known to preexist in 78.6% and rheumatic valvular heart
disease in 21.4% of cases. Organisms were identified by blood culture in
50%, the majority being Streptococcus viridalls (36% of cases). Vegetations
were detected by echocardiography in 64%. The overall death rate was
21.4%. Two patients with aortic stenosis developed IE after cardiac surgery
for repair of stenotic valves and both of them died. One patient with rheumatic
aortic and mitral valve insufficiency underwent valve replacement due
to intractable heart failure.
In conclusion, the frequent presence of underlying heart disease, the
rarity of IE in infancy, and the ominous prognosis of postoperative
endocarditis and aortic valve involvement are emphasized.
SHAHLA ROODPEYMACAUSES OF MORTALITY IN CARDIAC SURGERY REOPERATIONShttp://mjiri.iums.ac.ir/browse.php?a_id=1357&sid=1&slc_lang=en
From March 1990 to May 1993,309 patients underwent redo cardiac surgery
operation at the Shahid Rajai Heart Hospital in Tehran. Early mortality rates in
these patients showed a significant increase in comparison to patients undergoing
open heart surgery for the first time. Late mortality (at least one month after
surgery) in the patients was slightly increased also but less than early mortality
rates. The causes and factors involved in mortality of the patients are discussed in
detail. Comparison of mortality rates in our patients with that reported in the
literature reveals similar mortality in these patients, and thus the presence of
definite and irrefutable factors which influence this risk. These factors consist of
the patients' function class, age, surgical procedure, number of prosthetic valves
in place, duration of cardiopulmonary bypass, degree of hypothermia and duration
of myocardial ischemia. These factors are evaluated in this report.
KAMAL RAISSITRIAL OF A NON-LIVING CRUDE VACCINE AGAINST ZOONOTIC CUTANEOUS LEISHMANIASIShttp://mjiri.iums.ac.ir/browse.php?a_id=1356&sid=1&slc_lang=en
A field trial was canied outon60 volunteers selected in Yazd province, central
Iran, with a vaccine containing killed promastigotes of L. major prepared by the Razi
Institute, Hessarak. During these phase I studies which lasted for more than two
years, we examined acceptable doses of the vaccine alone or mixed with BCG. The
results so far indicate that 50 to 1000 µg of the vaccine alone can be well tolerated
without major side-effects. The mixture of BCG with 400 µg of the vaccine produced
pain and itching in five out of six volunteers, a self-limiting lymphadenopathy in one
out of six, and fever in three out of six. Further trials are planned with reduced doses
of BCG. The leishmania skin test became positive in a high proportion of the treated
individuals after vaccination. Circulating antibodies were detected from two weeks
to one month after vaccination.
M MOHEBALI