Trojan in iexplorer.exe

I started up my computer today and a warning popped up from norton that said that I had a high risk virus in C:\Windows\iexplore.exe and it was unable to repair the file. Anyone have any clue as to what I should do here?

When the scan is finished, the "Scan" button will change into a "Save Log" button.Press that, save the log, Ctrl-A to Select All, and copy its contents here. Most of what it lists will be harmless or even essential, don't fix anything yet.