And read This report to understand that the Number of Adverse Reactions actually detailed in that database is very, very, low because the reporting of Adverse Reactions is Voluntary and the vast majority of those Adverse Reactions never even Get Reported.

Under-reporting of adverse drug reactions : a systematic review.

Source

Drug Safety Research Unit, Southampton, UK.

Abstract

The purpose of this review was to estimate the extent of under-reporting of adverse drug reactions (ADRs) to spontaneous reporting systems and to investigate whether there are differences between different types of ADRs. A systematic literature search was carried out to identify studies providing a numerical estimate of under-reporting. Studies were included regardless of the methodology used or the setting, e.g. hospital versus general practice. Estimates of under-reporting were either extracted directly from the published study or calculated from the study data. These were expressed as the percentage of ADRs detected from intensive data collection that were not reported to the relevant local, regional or national spontaneous reporting systems. The median under-reporting rate was calculated across all studies and within subcategories of studies using different methods or settings. In total, 37 studies using a wide variety of surveillance methods were identified from 12 countries. These generated 43 numerical estimates of under-reporting. The median under-reporting rate across the 37 studies was 94% (interquartile range 82-98%). There was no significant difference in the median under-reporting rates calculated for general practice and hospital-based studies. Five of the ten general practice studies provided evidence of a higher median under-reporting rate for all ADRs compared with more serious or severe ADRs (95% and 80%, respectively). In comparison, for five of the eight hospital-based studies the median under-reporting rate for more serious or severe ADRs remained high (95%). The median under-reporting rate was lower for 19 studies investigating specific serious/severe ADR-drug combinations but was still high at 85%. This systematic review provides evidence of significant and widespread under-reporting of ADRs to spontaneous reporting systems including serious or severe ADRs. Further work is required to assess the impact of under-reporting on public health decisions and the effects of initiatives to improve reporting such as internet reporting, pharmacist/nurse reporting and direct patient reporting as well as improved education and training of healthcare professionals.

Amendment 8, US Constitution, 1791

Amendment 14, US Constitution 1868

Section. 1. All persons born or naturalized in the United States, and subject to the jurisdiction thereof, are citizens of the United States and of the State wherein they reside. No State shall make or enforce any law which shall abridge the privileges or immunities of citizens of the United States; nor shall any State deprive any person of life, liberty, or property, without due process of law; nor deny to any person within its jurisdiction the equal protection of the laws.

Equal Under Law

What D Bunker is NOT:
D Bunker is Not African American.
D Bunker is Not Hispanic American.
D Bunker is Not a Jewish American.
D Bunker is Not a Gay American.
D Bunker is an American, Period. And this PO'd American has had 10 times more than twice too much of enough of Anyone claiming special rights for themselves over Anyone else. Far too many good men and women of all races, creeds and colors have given Everything and more to establish that None of Us are better than the Next of Us, AS LAW, to allow Any Ideology, especially one which is Wholly Smoke and Mirrors, to rule and ruin the lives of Any of us.