Highways in Michigan and Ohio have reopened after massive pileups involving more than 50 vehicles left three people dead and dozens injured on Thursday.

The crashes were caused by snowy conditions currently hitting both states, and authorities said an interstate east of Cleveland was shut for more than 14 hours overnight.

The Lake County sheriff's office said about 20 people were injured in the chain reaction crash Thursday, which caused the closure of the busy road.

Highways in Michigan and Ohio have reopened after massive pileups involving involving more than 50 vehicles left three people dead and dozens injured on Thursday. Pictured is the I-96 near Lansing, where three died in a 40-car crash

This map shows the current snowcover across the country, as of Friday morning

Highway crews reopened the roadway Friday morning after the crash that involved a Greyhound bus and over a dozen trucks on Interstate 90.

Bus passenger Greg Carmichael told Fox8 he was heading home to Buffalo, New York, before conditions took a dangerous turn about an hour into the journey.

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He said a truck slammed into the bus from behind on the I-90, causing the domino effect crash.

Carmichael added several people on the bus were seriously injured.

This Weather Channel map shows where snow is expected to fall across the country on Friday

10-DAY WEATHER FORECAST AS THE POLAR VORTEX HITS THE EAST COAST

Chicago

Pittsburgh

New York City

Cleveland

Boston

Detroit

Buffalo

Friday

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Emergency crews work the scene of the multiple car pileup; in this picture, it is unclear where the cars and trucks begin and end, such was the force of the collision

Drivers wait in traffic along the interstate; the conditions have made driving a tough task along the icy Michigan interstate

A police car is pictured at the scene of a two-car crash where at least one driver was killed on Thursday

Chains are attached to semi-tractor rig as another rig gets set to try and pull it out of a ditch along Interstate 96

It comes after three people died and 11 others were hurt in a pileup on a snow-slickened Interstate 96 near Lansing, Michigan.

Lt. Eric Sanborn of the Livingston County Sheriff Department confirmed the three deaths Thursday in the pileup involving about 40 vehicles. He says 11 other people were transported to hospitals with non-life-threatening injuries.

Sanborn says westbound lanes of the interstate about 55 miles west of Detroit remained closed about 5½ hours after the pileup began Thursday morning.

Several crashes also were reported on Detroit-area freeways.

The Weather Channel forecasts the 'intense snow bands' will continue until at least Saturday.

The deep freeze causing the chaotic conditions is forecast to move east in the coming days, where temperatures are set to plummet.

Snow is already falling across western New York, with more than 17 inches has reported in Perrysburg, and 15.5 inches in East Concord.

Meanwhile in Wyoming, the temperature in Casper plunged to 31 degrees below zero overnight. It got so cold that the traveling Moscow Ballet couldn't start their buses.

Winter Storm warnings have been issued for the Portland, Oregon and Seattle areas, according to the Weather Channel. Winter Storm Caly is then expected to sweep through the Rockies, Plains, Midwest and Northeast into early next week.

As of late Thursday morning there was snow in northwest Oregon, including around Salem and Portland. This Saturday, Caly will then spread into the Plains and upper Midwest, while on Sunday, snow will spread into the Northeast, potentially hitting cities including Detroit, Cleveland and Pittsburgh.