Wide spread deployment and use of hydrogen and fuel cell technologies can occur only if hydrogen safety issues have been addressed in order to ensure that hydrogen fuel presents the same or lower level of hazards and associated risk compared to conventional fuel technologies. To achieve this goal, hydrogen safety research should be directed to address the remaining knowledge gaps using risk-informed approaches to develop engineering solutions and Regulation Codes and Standards (RCS) requirements that meet individual and societal risk acceptance criteria, yet are cost-effective and market-competitive. IA HySafe and JRC IET partnered to organize a Research Priorities Workshop in Berlin on October 16-17, 2012 hosted by BAM (on behalf of IA HySafe) to address knowledge gaps in CFD modelling of hydrogen safety issues. The findings of the workshop are described in the report. The document aims to become a reference document for researchers/scientists and technical (including industry) experts working in the area worldwide. It is also a welcomed contribution for the Fuel Cell and Hydrogen Joint Undertaking (FCH JU) and for other funding bodies/organizations that must make decisions on research programmes and during the selection/choice of projects to be financially supported pursuing the safe use of hydrogen within Horizon 2020 framework.