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The Cochrane Database of Systematic Reviews is considered the gold standard for
evidence-based medicine. Essential Evidence Plus includes the latest and most
up-to-date summaries of systematic reviews from the Cochrane Library, which are
the most rigorous and reliable evaluations of medical therapies available. You’ll
find summarized evaluations of the world’s best literature on the effectiveness of
therapy for 3,300+ clinical problems.

Artificial corneas versus donor corneas for repeat corneal transplantsCochrane Systematic Reviews, 3-Nov-2014Individuals who have failed one or more full thickness penetrating keratoplasties (PKs) may be offered repeat corneal surgery using an artificial or donor cornea. An artificial or prosthetic cornea is known as a keratoprosthesis. Both donor and artificial

Ascorbic acid for the treatment of Charcot-Marie-Tooth diseaseCochrane Systematic Reviews, 16-Dec-2015Charcot-Marie-Tooth disease (CMT) comprises a large group of different forms of hereditary motor and sensory neuropathy. The molecular basis of several CMT subtypes has been clarified during the last 20 years. Since slowly progressive muscle weakness and

Asenapine versus placebo for schizophreniaCochrane Systematic Reviews, 17-Nov-2015Schizophrenia is a highly prevalent and chronic disorder that comprises a wide range of symptomatology. Asenapine is a recently developed atypical antipsychotic that is approved by the US Food and Drug Administration (FDA) for the treatment of schizophren

Aspiration of the elbow joint for treating radial head fracturesCochrane Systematic Reviews, 21-Nov-2014Radial head fracture is the most common fracture of the elbow. It usually results from a fall onto an outstretched arm. In 1954, Mason classified these fractures into type 1 (undisplaced), type 2 (simple displaced), and type 3 (comminuted fractures). Aspi

Aspirin (single dose) for perineal pain in the early postpartum periodCochrane Systematic Reviews, 9-Feb-2017Perineal trauma (due to spontaneous tears, surgical incision (episiotomy) or in association with operative vaginal birth) is common after vaginal birth, and is often associated with postpartum perineal pain. Birth over an intact perineum may also lead to

Aspirin as adjunctive treatment for giant cell arteritisCochrane Systematic Reviews, 30-Jul-2014Giant cell arteritis (GCA) is a common inflammatory condition that affects medium and large-sized arteries and can cause sudden, permanent blindness. At present there is no alternative to early treatment with high-dose corticosteroids as the recommended s

Aspirin for acute treatment of episodic tension-type headache in adultsCochrane Systematic Reviews, 11-Oct-2017Tension-type headache (TTH) affects about 1 person in 5 worldwide. It is divided into infrequent episodic TTH (fewer than one headache per month), frequent episodic TTH (two to 14 headache days per month), and chronic TTH (15 headache days per month or mo

Aspirin for in vitro fertilisationCochrane Systematic Reviews, 14-Dec-2016Aspirin is used with the aim of optimising the chance of live birth in women undergoing assisted reproductive technology (ART), despite inconsistent evidence of its efficacy and safety (in terms of intraoperative bleeding during oocyte retrieval and risk

Aspirin for vascular dementiaCochrane Systematic Reviews, 17-Sep-2012Aspirin is widely prescribed for patients with a diagnosis of vascular dementia. In a survey of UK geriatricians and psychiatrists 80% of patients with clinical diagnoses of vascular dementia were prescribed aspirin. However, a number of queries remain un

Assessment and support during early labour for improving birth outcomesCochrane Systematic Reviews, 22-Aug-2017Progress in early labour is usually slow and may include painful uterine contractions. Women may feel distressed and lose their confidence during this phase. Support and assessment interventions have been assessed in two previous Cochrane Reviews. This re

Assisted reproductive technologies for male subfertilityCochrane Systematic Reviews, 23-Feb-2016Intra-uterine insemination (IUI), in vitro fertilisation (IVF) and intracytoplasmic sperm injection (ICSI) are frequently used fertility treatments for couples with male subfertility. The use of these treatments has been subject of discussion. Knowledge o

Assisted reproductive technology: an overview of Cochrane ReviewsCochrane Systematic Reviews, 18-Apr-2016As many as one in six couples will encounter problems with fertility, defined as failure to achieve a clinical pregnancy after regular intercourse for 12 months. Increasingly, couples are turning to assisted reproductive technology (ART) for help with con

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