Our special interest is devoted to stereochemical questions of stereogenic centers (C- or N-based), axes (C,C or C,N, sp2-sp2 or sp2-sp3), of chiral ‘planes’ or helices, both analytically and synthetically, and we test and optimize their bioactivities. Starting from rewarding sources (mostly tropical plants), we search for novel antiparasitic, antileukemic, and anticancer natural products including the elucidation of their full absolute stereostructures. Using biomimetic or non-biomimetic strategies, we elaborate synthetic pathways to the most rewarding metabolites; as an example, we have developed the 'lactone method' for the atropo-selective construction of highly hindered axially chiral biaryl and hetero-biaryl systems of any desired configuration.

Data privacy protection

By clicking 'OK' you are leaving the web sites of the Julius-Maximilians-Universität Würzburg and will be redirected to Facebook. For information on the collection and processing of data by Facebook, refer to the social network's data privacy statement.

Data privacy protection

By clicking 'OK' you are leaving the web sites of the Julius-Maximilians-Universität Würzburg and will be redirected to Twitter. For information on the collection and processing of data by Facebook, refer to the social network's data privacy statement.