American Academy of Microbiology

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Books

Search, browse, and discover hundreds of books that ASM publishes by internationally renowned authors and editors with expertise in a broad range of microbiology disciplines. Here you can purchase print or ebooks: print books are shipped (added shipping charges) and ebooks are downloadable files, in your choice of either ePub or PDF. You can also buy downloadable books by the chapter. Note that you have 48 hours to download your purchase from this site, after which access ends. Ebook/echapter purchases are final and nonrefundable.

You are at an exciting gateway into the world of microorganisms. With nothing more than basic lab equipment such as microscopes, Petri dishes, media, and a handful of reagents, you will learn to isolate, grow, and identify bacteria that live all around us. This is no ordinary microbiology laboratory course; not only will you learn how to streak plates, use a microscope, perform a Gram stain, and prepare serial dilutions and spread plates—fundamental skills found in every microbiologist’s toolkit—you will solve a series of public health–related challenges that many professional microbiologists encounter in their work.

By the end of this course, you will:

Determine the origin of a nosocomial infection. Using foundational and molecular methods, you will determine whether the infections occurring in hospitalized patients are the result of contaminated medical items.

Select the antibiotic to treat a patient with Crohn’s disease. You will find minimum inhibitory concentrations of various antibiotics for a Pseudomonas strain associated with Crohn’s disease.

Pinpoint the source of lettuce contaminated with E. coli. Using molecular tools you will investigate a common food safety challenge, antibiotic-resistant E. coli and the potential for spread of this resistance in the environment.

Find the farm releasing pathogens into a stream used for drinking water. Using bacteriophage load in water samples, you will locate the source of fecal contamination in the water supply of a village in an underdeveloped country.

Evaluate the potential of bacteria to cause a urinary tract infection. You will test for biofilms, quorum sensing behavior, and chemotaxis and assess which disinfectants would be most effective for sanitizing contaminated surfaces.

Microbiology educators and researchers Richard Meyer and Stacie Brown have created this hands-on, engaging introduction to the essential laboratory skills in the microbial sciences that is sure to change the way you view the world around you.

Examining the enormous potential of microbiome manipulation to improve health

Associations between the composition of the intestinal microbiome and many human diseases, including inflammatory bowel disease, cardiovascular disease, metabolic disorders, and cancer, have been elegantly described in the past decade. Now, whole-genome sequencing, bioinformatics, and precision gene-editing techniques are being combined with centuries-old therapies, such as fecal microbiota transplantation, to translate current research into new diagnostics and therapeutics to treat complex diseases. Bugs as Drugs provides a much-needed overview of microbes in therapies and will serve as an excellent resource for scientists and clinicians as they carry out research and clinical studies on investigating the roles the microbiota plays in health and disease.

In Bugs as Drugs, editors Robert A. Britton and Patrice D. Cani have assembled a fascinating collection of reviews that chart the history, current efforts, and future prospects of using microorganisms to fight disease and improve health. Sections cover traditional uses of probiotics, next-generation microbial therapeutics, controlling infectious diseases, and indirect strategies for manipulating the host microbiome. Topics presented include:

How well-established probiotics support and improve host health by improving the composition of the intestinal microbiota of the host and by modulating the host immune response.

The use of gene editing and recombinant DNA techniques to create tailored probiotics and to characterize next-generation beneficial microbes. For example, engineering that improves the anti-inflammatory profile of probiotics can reduce the number of colonic polyps formed, and lactobacilli can be transformed into targeted delivery systems carrying therapeutic proteins or bioengineered bacteriophage.

The association of specific microbiota composition with colorectal cancer, liver diseases, osteoporosis, and inflammatory bowel disease. The gut microbiota has been proposed to serve as an organ involved in regulation of inflammation, immune function, and energy homeostasis.

Fecal microbiota transplantation as a promising treatment for numerous diseases beyond C. difficile infection. Practical considerations for using fecal microbiota transplantation are provided, while it is acknowledged that more high-quality evidence is needed to ascertain the importance of strain specificity in positive treatment outcomes.

Because systems biology approaches and synthetic engineering of microbes are now high-throughput and cost-effective, a much wider range of therapeutic possibilities can be explored and vetted.

Massive increases in computing power and the ability to routinely sequence whole genomes of living organisms have begun to fundamentally alter our understanding of biology, medicine, and agriculture. At the intersection of the growing information and genomics revolutions sits bioinformatics, which uses modern computational power to reveal patterns in biological data sets, especially DNA, RNA, and protein sequences.

Computational Biology: A Hypertextbook, by Scott Kelley and Dennis Didulo, provides a wonderful introduction for anyone who wants to learn the basics of bioinformatics. This book is more than a textbook because of the wealth of online ancillary materials and how the print and electronic components are integrated to form a complete educational resource. Aspects that make Computational Biology: A Hypertextbook a unique and valuable tool for teaching and learning bioinformatics include

Clear explanations of the basic biology of DNA, RNA, and proteins and how the related bioinformatics algorithms work

Extensive exercises that enable students to practice with the same bioinformatics applications that are used by scientists worldwide

Tutorials, sample data sets, and interactive learning tools developed with teachers in mind and field-tested by hundreds of students

Online tutorials and curated web links that are accurate (instead of frustrating!) and won’t lead to dead ends

Online resources that work on multiple platforms and electronic devices

Computational Biology: A Hypertextbook is written in an accessible voice, punctuated with humor, and designed to significantly increase computational competencies. Biology and computer science undergraduate and graduate students will thoroughly enjoy learning from this unique hypertextbook, as will anyone with an interest in exploring this burgeoning topic.

Fungi research and knowledge grew rapidly following recent advances in genetics and genomics. This book synthesizes new knowledge with existing information to stimulate new scientific questions and propel fungal scientists on to the next stages of research. This book is a comprehensive guide on fungi, environmental sensing, genetics, genomics, interactions with microbes, plants, insects, and humans, technological applications, and natural product development.

The Microbial World: A Coloring Book of Microbe-Inspired Postcards features the work of top illustrators’ take on unique microbes and microscopic animals, ranging from Prochloroccus to the tardigrade. Each postcard showcases the favorite microbe or microscopic animal of thirteen renowned microbial science experts, complete with a short quote about why they love them! Get coloring, be creative, and mail one to your favorite microbiologist!

Intersted in buying this title? Please email books@asmusa.org with the subject heading "Kucers' The Use of Antibiotics, Seventh Edition."

Kucers’ The Use of Antibiotics is the definitive, internationally-authored reference, providing everything that the infectious diseases specialist and prescriber needs to know about antimicrobials in this vast and rapidly developing field. The much-expanded Seventh Edition comprises 4800 pages in 3 volumes in order to cover all new and existing therapies, and emerging drugs not yet fully licensed. Concentrating on the treatment of infectious diseases, the content is divided into four sections - antibiotics, anti-fungal drugs, anti-parasitic drugs, and anti-viral drugs - and is highly structured for ease of reference.

Each chapter is organized in a consistent format, covering susceptibility, formulations and dosing (adult and pediatric), pharmacokinetics and pharmacodynamics, toxicity, and drug distribution, with detailed discussion regarding clinical uses - a feature unique to this title. Compiled by an expanded team of internationally renowned and respected editors, with expert contributors representing Europe, Africa, Asia, Australia, South America, the US, and Canada, the Seventh Edition adopts a truly global approach. It remains invaluable for anyone using antimicrobial agents in their clinical practice and provides, in a systematic and concise manner, all the information required when prescribing an antimicrobial to treat infection.

Key Features

The definitive major reference work in the field, covering key information that the infectious diseases specialist will need to know about antimicrobial drugs

Comprehensive coverage of the drug available, including those new to the market and, importantly, those currently under trial

Highly standardized content, structured for ease of reference

Globally applicable, compiled by an international team of expert editors and contributors

Added to this edition - new antivirals, particularly the highly effective compounds now available to treat HIV and viral hepatitis; new antibiotics - beta-lactamase inhibitors and cephalosporins, quinolones and fluoroquinolones, anti-tuberculosis agents; plus new antifungals and antiparasitics

Antisepsis, Disinfection, and Sterilization: Types, Action, and Resistance, by Gerald E. McDonnell, is a detailed and accessible presentation of the current methods of microbial control. Each major category, such as physical disinfection methods, is given a chapter, in which theory, spectrum of activity, advantages, disadvantages, and modes of action of the methods are thoroughly and clearly presented. Sufficient background on the life cycles and general anatomy of microorganisms is provided so that the reader who is new to microbiology will better appreciate how physical and chemical biocides work their magic on microbes. Other topics in the book include:

Evaluating the efficacy of chemical antiseptics and disinfectants, and of physical methods of microbial control and sterilization.

Understanding how to choose the proper biocidal product and process for specific applications.

Antisepsis of skin and wounds and the biocides that can be used as antiseptics.

Classic methods of physical sterilization, such as, moist heat and dry heat sterilization, ionizing radiation, and filtration, along with newer methods, including, the use of plasma or pulsed light.

Chemical sterilization methods that use ethylene oxide, formaldehyde, or a variety of other oxidizing agents.

A detailed look at the modes of action of biocides in controlling microbial growth and disrupting microbial physiology.

Mechanisms that microorganisms use to resist the effects of biocides.

The second edition of Antisepsis, Disinfection, and Sterilization: Types, Action, and Resistance is well suited as a textbook and is outstanding as a reference book for facilities managers and application engineers in manufacturing plants, hospitals, and food production facilities. It is also essential for public health officials, healthcare professionals, and infection control practitioners.

In the clinical microbiology laboratory, blood is a critical diagnostic sample that, in the majority of cases is sterile (or is it?). However, when microbes gain access to and multiply in the bloodstream, it can result in life-threatening illness including sepsis. Mortality rates from bloodstream infection and sepsis range from 25% to 80%, killing millions of people annually. Blood cultures are a vital technology used in the microbiology laboratory to isolate and identify microbes and predict their response to antimicrobial therapy.

The Dark Art of Blood Cultures, edited by Wm. Michael Dunne, Jr., and Carey-Ann D. Burnham, surveys the entire field of blood culture technology, providing valuable information about every phase of the process, from drawing samples to culture methods to processing positive cultures. The Dark Art of Blood Cultures is organized around several major topics.

History of blood culture methods. Details the timeline of blood culture methods from manual through automated and describes the technological development of the leading automated blood culture systems (Bactec, BacT/Alert, and VersaTREK).

Detection of pathogens directly from blood specimens. Describes currently available CE marked and FDA-cleared commercial tests using both phenotypic and genotypic markers, including their strengths and limitations.

The workflow of culturing blood. Includes best practices from specimen collection to culture system verification, processing positive cultures for microbe identification and antibiotic susceptibility determination, along with the epidemiology of positive blood cultures and the value of postmortem blood cultures.

Microorganisms in the blood. Examines the concept of a blood microbiome in healthy and diseased individuals.

The Dark Art of Blood Cultures is a resource that clinicians, laboratorians, lab directors, and hospital administrators will find engaging and extremely useful.

In this completely revised edition an international team of experts presents nearly every facet of the prevention, diagnosis, and treatment of tuberculosis and nontuberculous mycobacterial infections. In addition to presenting the latest clinical data, epidemiological findings, and policy and strategy recommendations of the World Health Organization, the book also provides detailed information on the clinical, public health, and policy aspects of tracking and treating tuberculosis. This book is a resource for anyone working to prevent and treat tuberculosis and associated infections, from infectious disease specialists to scientists, policymakers, and epidemiologists.

The Power of Plagues presents a rogues' gallery of epidemic-causing microorganisms placed in the context of world history. Author Irwin W. Sherman introduces the microbes that caused these epidemics and the people who sought (and still seek) to understand how diseases and epidemics are managed. What makes this book especially fascinating are the many threads that Sherman weaves together as he explains how plagues past and present have shaped the outcome of wars and altered the course of medicine, religion, education, feudalism, and science. Cholera gave birth to the field of epidemiology. The bubonic plague epidemic that began in 1346 led to the formation of universities in cities far from the major centers of learning (and hot spots of the Black Death) at that time. And the Anopheles mosquito and malaria aided General George Washington during the American Revolution. Sadly, when microbes have inflicted death and suffering, people have sometimes responded by invoking discrimination, scapegoating, and quarantine, often unfairly, against races or classes of people presumed to be the cause of the epidemic.

Pathogens are not the only stars of this book. Many scientists and physicians who toiled to understand, treat, and prevent these plagues are also featured. Sherman tells engaging tales of the development of vaccines, anesthesia, antiseptics, and antibiotics. This arsenal has dramatically reduced the suffering and death caused by infectious diseases, but these plague protectors are imperfect, due to their side effects or attenuation and because microbes almost invariably develop resistance to antimicrobial drugs.

The Power of Plagues provides a sobering reminder that plagues are not a thing of the past. Along with the persistence of tuberculosis, malaria, river blindness, and AIDS, emerging and remerging epidemics continue to confound global and national public health efforts. West Nile virus, Lyme disease, and Ebola and Zika viruses are just some of the newest rogues to plague humans.

The argument that civilization has been shaped to a significant degree by the power of plagues is compelling, and The Power of Plagues makes the case in an engaging and informative way that will be satisfying to scientists and non-scientists alike.

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Presents all facets of food microbiology to undergraduates

The multidisciplinary nature of food microbiology is one of the things that make it so fascinating as a career. Food microbiologists must understand basic microbiology, the roles of beneficial microbes, food safety regulations and policy, and the proper practices that ensure safe and healthy food for billions of people. They must also be nimble thinkers, willing to embrace new analytical methods, eager to solve problems, and ever vigilant about keeping the food supply safe.

The fourth edition of Food Microbiology: An Introduction is designed for undergraduate courses in food science, nutrition, and microbiology. This edition has been substantially updated with new information on topics like the Food Safety Modernization Act and the use of bacteriophage as antimicrobial agents, while retaining the pedagogy that students and professors appreciate. Written in a clear and easy-to-understand style, the textbook is divided into four sections:

Basics of food microbiology presents the growth processes of food microorganisms, the biology of spores and sporeformers, and the establishment of microbiological criteria in food safety programs, and it introduces students to some of the methods used to detect and enumerate microbes in food and food handling equipment.

Foodborne pathogenic bacteria opens with a discussion about the regulatory agencies and surveillance systems responsible for keeping the United States food supply safe. The remainder of the section is a rogue’s gallery of pathogenic bacteria found in food.

Other microbes important in food examines the many beneficial and detrimental ways that microorganisms affect our food supply. section opens with a look at numerous foods, like beer, bread, pickles, and cheeses, created by the fermentation reactions of lactic acid bacteria and yeast. The rest of the section looks at microbes that are less desirable: the spoilers of food, toxigenic molds, and foodborne parasites. This section closes with a look at viruses and prions.

Control of microorganisms in food discusses the tactics used to inhibit microbial growth in food. The section ends with a chapter on the essentials of developing quality sanitation and HACCP programs in food processing facilities.

The gold standard for the selection, collection, and transport of clinical microbiological samples.

The face of infectious diseases has changed since the second edition of A Guide to Specimen Management in Clinical Microbiology was published in 1999. Despite improved surveillance and vaccinations, tens of millions of people visit physicians annually for a possible microbial or parasitic infection. Identifying the infectious agent in a patient remains a top priority, and proper identification begins with careful collection, appropriate packaging and transport, and responsible reporting of patient specimens.

For these reasons, A Guide to Specimen Management in Clinical Microbiology is as essential as ever. The book is divided into four sections and features tips and words of wisdom that come directly from experts in the field.

Communicating laboratory needs explains to all members of the healthcare team what role the clinical microbiology laboratory plays in patient care. It also emphasizes that microbiology specimens contain living organisms that require proper handling to remain viable.

Specimen management policies and rationale provides a framework for creating a specimen management policy and a specimen collection and handling manual that, together, support good medicine and good laboratory practice.

Specimen collection and processing contains detailed protocols for selecting, collecting, storing, and transporting adult and pediatric specimens to the clinical microbiology laboratory. This section can serve as a model for preparation of the specimen management manual.

Specimen management summary tables are handy reference guides that provide answers to most questions regarding the laboratory needs for a wide variety of bacterial, viral, fungal, and parasitic organisms found in patient specimens.

Because patient care is a team effort, all members of the health care team—physicians, nurses, nurse practitioners, physician assistants, specimen collectors, and laboratorians—will benefit greatly from reading this book.

Now in its fifth edition, Biological Safety: Principles and Practices (Feb. 2017) remains the most comprehensive biosafety reference. A resource for biosafety professionals, instructors, and those who work with pathogenic agents in any capacity, Biological Safety is also a critical reference for laboratory managers and those responsible for managing biohazards in a range of settings.

This comprehensive and authoritative volume on infections of the urinary tract covers the range of the field, from molecular pathogenesis to the host response to clinical diagnosis and management. Written for microbiologists, clinical microbiologists, urologists, and pathologists interested in UTIs.

The structure, functions, and interactions of myeloid cells have long been the focus of research and therapeutics development. Yet, much more remains to be discovered about the complex web of relationships that makes up the immune systems of animals. Scientists today are applying genome-wide analyses, single-cell methods, gene editing, and modern imaging techniques to reveal new subclasses of differentiated myeloid cells, new receptors and cytokines, and important interactions among immune cells.

In Myeloid Cells in Health and Disease: A Synthesis, Editor Siamon Gordon has assembled an international team of esteemed scientists to provide their perspectives of myeloid cells during innate and adaptive immunity. The book begins by presenting the foundational research of Paul Ehrlich, Elie Metchnikoff, and Donald Metcalf. The following chapters discuss evolution and the life cycles of myeloid cells; specific types of differentiated myeloid cells, including macrophage differentiation; and antigen processing and presentation. The rest of the book is organized by broad topics in immunology, including:

the recruitment of myeloid and other immune cells following microbial infection

the role of myeloid cells in the inflammation process and the repair of damaged tissue

receptors and downstream signaling pathways that are activated following ligand-receptor binding

roles of myeloid cells during microbial and parasite infections

contributions of myeloid cells in atherosclerosis

myeloid-derived suppressor cells in tumor development and cancer

Myeloid Cells in Health and Disease: A Synthesis will benefit graduate students and researchers in immunology, hematology, microbial pathogenesis, infectious disease, pathology, and pharmacology. Established scientists and physicians in these and related fields will enjoy the book’s rich history of myeloid cell research and suggestions for future research directions and potential therapies.

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Since 1994, Molecular Biotechnology: Principles and Applications of Recombinant DNA has introduced students to the fast-changing world of molecular biotechnology. With each revision, the authors have extensively updated the book to keep pace with the many new techniques in gene isolation and amplification, nucleic acid synthesis and sequencing, gene editing, and their applications to biotechnology. In this edition, authors Bernard R. Glick and Cheryl L. Patten have continued that tradition, but have also overhauled the book’s organization to

Detail fundamental molecular biology methods and recombinant protein engineering techniques, which provides students with a solid scientific basis for the rest of the book.

Present the processes of molecular biotechnology and its successes in medicine, bioremediation, raw material production, biofuels, and agriculture.

Examine the intersection of molecular biotechnology and society, including regulation, patents, and controversies around genetically modified products.

Filled with engaging figures that strongly support the explanations in the text, Molecular Biotechnology: Principles and Applications of Recombinant DNA presents difficult scientific concepts and technically challenging methods in clear, crisp prose.

This excellent textbook is ideal for undergraduate and graduate courses in introductory biotechnology, as well as, courses dedicated to medical, agricultural, environmental, and industrial biotechnology applications.

Virology is one of the most dynamic and rapidly changing fields of clinical medicine. For example, sequencing techniques from human specimens have identified numerous new members of several virus families, including new polyomaviruses, orthomyxoviruses, and bunyaviruses.

Clinical Virology, Fourth Edition, has been extensively revised and updated to incorporate the latest developments and relevant research. Chapters written by internationally recognized experts cover novel viruses, pathogenesis, epidemiology, diagnosis, treatment, and prevention, organized into two major sections:

One third of the world’s population is infected with tuberculosis (TB), with about 10 million new cases annually. To combat TB and its agent, Mycobacterium tuberculosis, the World Health Organization launched The End TB Strategy, which aims to slash the suffering and cost of TB by 2035.

This makes the second edition of Tuberculosis and the Tubercle Bacillus, edited by Jacobs, McShane, Mizrahi, and Orme, an extremely valuable resource for scientists and clinicians. The editors have gathered their colleagues from around the world to present the latest on the molecular biology of M. tuberculosis and related species, the host-pathogen interactions that enable invasion, and the host’s immune response to M. tuberculosis infection. The basic, clinical, and translational research presented in this book supports the goals of WHO’s End TB Strategy by driving toward the development of effective vaccines, rapid molecular diagnostics, and anti-TB drugs.

Creating an effective tuberculosis vaccine. Understand the innate and adaptive immune response to M. tuberculosis infection, its study in established animal models, and how this information is being used to develop new vaccines against TB.

Formulating new antituberculosis drugs. Learn the challenges and methods for evaluating new drugs in preclinical trials with a focus on drugs that work against “persisters” and those that act on the electron transport complex and ATP synthase of M. tuberculosis.

Overcoming the challenges of diagnosing tuberculosis. Review new diagnostic tools that are simple, rapid, affordable, specific, sensitive, and safe, including molecular-based diagnostic methods such as GeneXpert MTB/RIF.

Using molecular, genomic, and bioinformatics tools to understand the biology and evolution of Mycobacterium. Explore current research on the molecular mechanisms that M. tuberculosis uses to evade the immune system, enter a state of nonreplicating persistence, and become reactivated.

The second edition of Tuberculosis and the Tubercle Bacillus presents the latest research on a microorganism that is exquisitely well adapted to its human host. This pathogen continues to confound scientists, clinicians, and public health specialists, who will all find much valuable information in this comprehensive set of reviews.

A comprehensive examination of the technical and anthropological issues in this new multidisciplinary field

Only recently was it determined that two of the world’s most devastating plagues, the plague of Justinian and the medieval Black Death, were caused by distinct strains of the same pathogen. Use of paleomicrobiological techniques led to this discovery. This work is just one example of the historical mysteries that this emerging field has helped to clarify. Others, such as when tuberculosis began to afflict humans, the role of lice in plague pandemics, and the history of smallpox, are explored and further illuminated in Paleomicrobiology of Humans.

Led by editors Michel Drancourt and Didier Raoult, the book’s expert contributors address larger issues using paleomicrobiology. These include the recognition of human remains associated with epidemic outbreaks, identification of the graves associated with disasters, and the discovery of demographic structures that reveal the presence of an epidemic moment. In addition, this book reviews the technical approaches and controversies associated with recovering and sequencing very old DNA and surveys modern human diseases that have ancient roots.

Essentially, paleomicrobiologists aim to identify past epidemics at the crossroads of different specialties, including anthropology, medicine, molecular biology, and microbiology. Thus, this book is of great interest not only to microbiologists but to medical historians and anthropologists as well.

Paleomicrobiology of Humans is the first comprehensive book to examine so many aspects of this new, multidisciplinary, scientific field.

For over 40 years the Manual of Molecular and Clinical Laboratory Immunology has served as the premier guide for the clinical immunology laboratory. Led by Editor-in-Chief, Barbara Detrick, the Manual has reflected the exponential growth in the field of immunology over the past decades from basic serology testing to the present wide range of molecular analyses. This eighth edition reflects the latest advances and developments in the diagnosis and treatment of patients with infectious and immune-mediated disorders.

The Manual features detailed descriptions of general and specific methodologies, placing special focus on the interpretation of laboratory findings, and covers the immunology of infectious diseases, including specific pathogens, as well as the full range of autoimmune and immunodeficiency diseases, cancer, and transplantation.

Written to guide the laboratory director, the Manual will also appeal to other laboratory scientists, especially those working in clinical immunology laboratories, and pathologists. It is also a useful reference for physicians, mid-level providers, medical students, and allied health students with an interest in the role that immunology plays in the clinical laboratory.

In response to the ever-changing needs and responsibilities of the clinical microbiology field, Clinical Microbiology Procedures Handbook, Fourth Edition has been extensively reviewed and updated to present the most prominent procedures in use today.

The Clinical Microbiology Procedures Handbook provides step-by-step protocols and descriptions that allow clinical microbiologists and laboratory staff personnel to confidently and accurately perform all analyses, including appropriate quality control recommendations, from the receipt of the specimen through processing, testing, interpretation, presentation of the final report, and subsequent consultation.

Do you need access for multiple users? To purchase a site license contact Rachel Peckover.

Note, for bundle purchases VAT will be assessed at 50% of the total bundle price ($210 for non-members and $168 for members).

Environmental microbiology, the study of the roles that microbes play in all planetary environments, is one of the most important areas of scientific research. The Manual of Environmental Microbiology, Fourth Edition, provides comprehensive coverage of this critical and growing field.

Thoroughly updated and revised, the Manual is the definitive reference for information on microbes in air, water, and soil and their impact on human health and welfare. Written in accessible, clear prose, the manual covers four broad areas: general methodologies, environmental public health microbiology, microbial ecology, and biodegradation and biotransformation. This wealth of information is divided into 18 sections each containing chapters written by acknowledged topical experts from the international community.

Specifically, this new edition of the Manual

Incorporates a summary of the latest methodologies used to study microorganisms in various environments

Synthesizes the latest information on the assessment of microbial presence and microbial activity in natural and artificial environments

The Manual of Environmental Microbiology is an essential reference for environmental microbiologists, microbial ecologists, and environmental engineers, as well as those interested in human diseases, water and wastewater treatment, and biotechnology.

The essential reference for selecting, using, and interpreting methods and results related to human parasitic infections

This major work by Lynne Garcia, a recognized authority on diagnostic parasitology, has been completely updated to include the dramatic changes that have occurred in the field of diagnostic medical parasitology over the past decade. Diagnostic Medical Parasitology, Sixth Edition, features newly recognized human parasites, improved diagnostic techniques defined by new regulatory requirements, implementation of testing based on molecular techniques, expanded tables and color photographs, and the latest information on parasitic infections.

Diagnostic Medical Parasitology contains two sections within this single volume. The first provides clear, concise diagnostic procedures for clinical laboratory use, including ordering and collection recommendations, techniques for parasite recovery and identification that are relevant throughout the world. This section also thoroughly examines the pros and cons of various diagnostic options, including extensive report comments for result clarification and enhancement.

The second section presents comprehensive discussions of common and uncommon individual human parasites. It provides information related to life cycle, morphology, and clinical disease in both the immunocompetent and immunocompromised patient including diagnosis, treatment, epidemiology, and prevention. There are also expanded sections on artifacts, case histories, and histologic findings that provide discussion and tips related to potential diagnostic problems. Both book sections feature extensive color illustrations related to each technique and parasite presented, as well as expanded color plates of human parasites.

"Diagnostic Medical Parasitology is a critical reference for every microbiology laboratory. It covers all aspects of human medical parasitology and provides detailed, comprehensive, relevant diagnostic methods in one volume. The color images are fantastic for use in assisting you in the identification of parasites. To ensure that your microbiology personnel are employing practical quality procedures in the area of parasitology, you need this book!"

The immunocompromised patient population is increasing throughout the world. Major advances in transplantation techniques have expanded access to lifesaving therapies and improved outcomes in these high-risk populations. An understanding of the biology of these infections, host conditions, and the limitations of technologies used to detect and quantify such pathogens is critical to optimal care.

This new edition of Diagnostic Microbiology of the Immunocompromised Host covers all aspects of state-of-the-art diagnostics for infectious complications in the immunocompromised patient. Editors Randall Hayden, Karen Carroll, Yi-Wei Tang, and Donna Wolk assembled the contributions of a team of preeminent authors to discuss a broad range of topics, including

relevant aspects of host biology, antineoplastic, and transplantation techniques and the basis of immunosuppressive conditions ranging from diabetes to age-related immunosuppression

approaches, interpretations, and limitations of laboratory diagnosis of infections by a wide range of specific etiologic agents

special topics such as prosthetic devices and catheters, healthcare acquired infections, and morphologic considerations (anatomic pathology)

future diagnostic technologies and their potential impact on the field

Diagnostic Microbiology of the Immunocompromised Host is a resource for laboratory medicine specialists, pathologists, technologists, students, and clinical care professionals who are involved or interested in the care of the immunocompromised host.

Presenting the latest molecular diagnostic techniques in one comprehensive volume

The molecular diagnostics landscape has changed dramatically since the last edition of Molecular Microbiology: Diagnostic Principles and Practice in 2011. With the spread of molecular testing and the development of new technologies and their opportunities, laboratory professionals and physicians more than ever need a resource to help them navigate this rapidly evolving field.

Editors David Persing and Fred Tenover have brought together a team of experienced researchers and diagnosticians to update this third edition comprehensively, to present the latest developments in molecular diagnostics in the support of clinical care and of basic and clinical research, including next-generation sequencing and whole-genome analysis. These updates are provided in an easy-to-read format and supported by a broad range of practical advice, such as determining the appropriate type and quantity of a specimen, releasing and concentrating the targets, and eliminating inhibitors. Molecular Microbiology: Diagnostic Principles and Practice:

Offers tested and proven applications of molecular diagnostics for the diagnosis of infectious diseases, including point-of-care testing

Illustrates and summarizes key concepts and techniques with detailed figures and tables

Discusses emerging technologies, including the use of molecular typing methods for real-time tracking of infectious outbreaks and antibiotic resistance

Advises on the latest quality control and quality assurance measures

Explores the increasing opportunities and capabilities of information technology

Molecular Microbiology: Diagnostic Principles and Practice is a textbook for molecular diagnostics courses that can also be used by anyone involved with diagnostic test selection and interpretation. It is also a useful reference for laboratories and as a continuing education resource for physicians. “Molecular methods have become indispensable for the rapid and accurate diagnosis of infections, and this book provides an authoritative guide to the field. I highly recommend it.”

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Brings the excitement, breadth, and power of the modern microbial sciences to the next generation of students and scientists.

This new edition of Microbe is an eloquent and highly readable introduction to microbiology that will engage and excite science majors and pre-health professionals. The authors, all prominent scientists, have carefully crafted this lively narrative to bring key microbiology concepts to life and promote a lifelong passion for the microbial sciences.

Far more than a comprehensive reference book, Microbe is replete with case studies, ranging from sauerkraut fermentation to the cholera outbreak in Haiti, that illustrate the impact of key microbiology concepts on real-world scenarios. To further engage students and deepen their understanding of both the principles and practice of science, each chapter includes multiple active learning exercises that encourage students to demonstrate their understanding and application of concepts, as well as video, spoken, and written resources. Questions are posed throughout the book to introduce the next key concept and to prompt students to actively participate in the learning experience.

An equally valuable tool for instructors who teach a traditional lecture format and those who emphasize active learning in their classroom, Microbe integrates key concepts, learning outcomes, and fundamental statements directly from the ASM Recommended Curriculum Guidelines for Undergraduate Microbiology Education.

“This is a fantastic text! Written in a comfortable, conversational style, it grabs the readers’ attention immediately, sparking their curiosity and keeping them engaged throughout each chapter while they seek and find answers to questions posed at the beginning of each section. A true joy to read. I recommend it highly for both traditional and flipped classrooms.”

--Peggy Cotter, PhD, Professor, Department of Microbiology and Immunology, UNC School of Medicine

The clinical virology field is rapidly evolving and, as a result, physicians and clinical laboratory virologists must have a reliable reference tool to aid in their ability to identify and diagnose viral infections to prevent future outbreaks.

In this completely revised edition of the Clinical Virology Manual, Editor in Chief, Michael Loeffelholz, along with Section Editors, Richard Hodinka, Benjamin Pinsky, and Stephen Young, have complied expert perspectives of a renowned team of clinical virology experts and divided these contributions into three sections to provide

the latest information on the diagnosis of viral infections, including ebola, HIV and Human papillomavirus

state of the art diagnostic technologies, including next-generation sequencing and nucleic acid amplification methods

taxonomy of clinically important viruses such as polyomaviruses and zoonotic viruses

This comprehensive reference also includes three appendices with vital information on reference virology laboratories at the Centers for Disease Control and Prevention, state and local public health laboratories, and international reference laboratories and laboratory systems.

Additionally, a new section “Diagnostic Best Practices,” which summarizes recommendations for diagnostic testing, and cites evidence-based guidelines, is included in each viral pathogens chapter.

Clinical Virology Manual, Fifth Edition serves as a reference source to healthcare professionals and laboratorians in providing clinical and technical information regarding viral diseases and the diagnosis of viral infections.

A day at the beach: delightful, restorative, and potentially dangerous.

Leisure activities, from the mundane to the exotic, expose us to a growing list of pathogenic microbes, some new and many increasingly resistant to current therapies. Common pets, livestock, traveling, and cuisine all have the potential to cause illnesses that may be difficult to diagnose and treat.

Engagingly written by a team of infectious disease specialists and edited by David Schlossberg, Infections of Leisure features 19 chapters focused on the infection risks associated with particular types of activities, including camping, playing sports, interacting with animals, receiving body modifications, and mountain climbing. This new edition includes vibrant, full-color images, recommended readings chosen by expert authors, and practical tips in each chapter.

Useful for health care professionals, microbial scientists, and infectious diseases specialists, the information in Infections of Leisure will support confident identification of leisure-associated infections and enable informed choices, as well as provide an understanding of the risks posed to human health.

David Schlossberg, MD, FACP, is Professor of Medicine at Temple University School of Medicine and Adjunct Professor of Medicine at the University of Pennsylvania School of Medicine. He is currently Medical Director of the Tuberculosis Control Program for the Philadelphia Department of Public Health. A graduate of Yale University and Tufts Medical School, Dr. Schlossberg completed his medical residency at Mount Sinai Hospital, and his infectious disease fellowship at Emory University. Dr. Schlossberg is editor of Tuberculosis and Nontuberculous Mycobacterial Infections, Sixth Edition (ASM Press, 2011). He has written hundreds of articles on internal medicine and infectious diseases.

Today, more than 200 diseases occurring in humans and animals are known to be mutually transmitted. Classic infectious diseases such as rabies, plague, and yellow fever have not been eradicated despite major efforts.

New zoonotic diseases are appearing due to global conditions such as overpopulation, wars, and food scarcity, which facilitate human contact with rodents, stray animals, and their parasites. In addition, humans are unwittingly becoming accidental hosts and new links in an infectious chain by engaging in activities such as survival training, which involves camping in open areas, and consumption of raw or insufficiently cooked food.

Zoonotic infections cause a variety of symptoms that often do not provide clear evidence of a known disease. Zoonoses, Fourth Edition, describes most occurring worldwide zoonoses and facilitates the identification, diagnosis, and treatment of zoonotic infections.

Written by a team of doctors, medical microbiologists and veterinarians, this revised and updated edition—translated from the noted German reference Zoonosen—covers all aspects of the epidemiology and prevention of zoonotic diseases supported by clear descriptions of various illnesses. Specifically, this fourth edition covers zoonoses caused by:

iruses, bacteria, fungi, and parasites

infections caused by animal bites

infections and intoxications by animal foods

iatrogenic transmission of zoonotic pathogens

Zoonoses is an indispensable reference for both clinicians and laboratorians.

Despite the use of antibiotics, bacterial diseases continue to be a critical issue in public health, and bacterial pathogenesis remains a tantalizing problem for research microbiologists. This new edition of Virulence Mechanisms of Bacterial Pathogens broadly covers the knowledge base surrounding this topic and presents recently unraveled bacterial virulence strategies and cutting-edge therapies.

A team of editors, led by USDA scientist Indira Kudva, compiled perspectives from experts to explain the wide variety of mechanisms through which bacterial pathogens cause disease: the host interface, host cell enslavement, and bacterial communication, secretion, defenses, and persistence. A collection of reviews on targeted therapies rounds out the seven sections of this unique book. The new edition provides insights into some of the most recent advances in the area of bacterial pathogenesis, including:

how metabolism shapes the host-pathogen interface

interactions across species and genera

secretion systems mechanisms

evasion, survival, and persistence mechanisms

new therapies targeting various adaptive and virulence mechanisms of bacterial pathogens

“This new edition of Virulence Mechanisms of Bacterial Pathogens is edited by renowned experts in the field and encompasses state-of-the-art review articles and critical overviews. From bacterial-host interactions and communication to bacterial secretion systems, persistence, and novel targeted therapies, this is a ‘MUST READ’ for anyone studying bacterial infectious agents.”

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Antibiotics: Challenges, Mechanisms, Opportunities focuses on antibiotics as small organic molecules, from both natural and synthetic sourcFes. Understanding the chemical scaffold and functional group structures of the major classes of clinically useful antibiotics is critical to understanding how antibiotics interact selectively with bacterial targets.

This textbook details how classes of antibiotics interact with five known robust
bacterial targets: cell wall assembly and maintenance, membrane integrity, protein
synthesis, DNA and RNA information transfer, and the folate pathway to
deoxythymidylate. It addresses the universe of bacterial resistance, from the
concept of the resistome to the three major mechanisms of resistance: antibiotic
destruction, antibiotic active efflux, and alteration of antibiotic targets.
Antibiotics also covers the biosynthetic machinery for the major classes of natural
product antibiotics.

How should our limited inventory of effective antibiotics be addressed?

Antibiotics is a textbook for graduate courses in chemical biology,
pharmacology, medicinal chemistry, microbiology and biochemistry courses. It is also
a valuable reference for microbiologists, biological and natural product chemists,
pharmacologists, and research and development scientists.

“This book provides all the information needed to understand antibiotic genetics,
biochemistry, mechanism of action and resistance. Most importantly, Walsh and
Wencewicz are optimistic of the prospects of the discovery of novel therapeutic
agents obtained by the manipulation of strains and biosynthetic pathways. This
beautifully written book deserves to be read and implemented by everyone,
especially the pessimists who believe that the antibiotic era has ended. In
Antibiotics: Challenges, Mechanisms, Opportunities, Walsh and Wencewicz
provide the definitive, ultimate compendium of everything antibiotic.”

— Julian Davies, Professor of Microbiology and Immunology, Life Sciences Institute, University of British Columbia Vancouver

The first articles describing the sporulation process were published by Robert Koch and Ferdinand Cohn in the late 19th century. Although most of the work accomplished in the past 50 years has focused on the model organism Bacillus subtilis, more recent work significantly expanded the scope of sporulation research to integrate medically relevant spore pathogens, such as B. anthracis and Clostridium difficile, as well as investigations of the ecology of spore-forming species. This new direction is supported by an explosion of novel techniques that can also be applied to nonmodel organisms, such as next-generation sequencing, metagenomics, and transcriptomics.

The Bacterial Spore provides a comprehensive series of reviews of the major topics in spore biology that represent intensive, cutting-edge spore research. Editors Adam Driks and Patrick Eichenberger assembled chapters written by a team of diverse and multidisciplinary experts in biodefense and microbial forensics to produce an overview of topics of spore research, such as spore molecular biology, bioremediation, systems biology, issues in biodefense, and the challenge of food safety that is accessible to any reader, regardless of expertise. The Bacterial Spore also encompasses the diversity of spore research, which will appeal to those seeking to broaden their knowledge.

The Bacterial Spore is a reference for a wide range of readers, including geneticists, cell biologists, physiologists, structural and evolutionary biologists, applied scientists, advanced undergraduate and graduate students, and nonresearchers, such as national security professionals.

“The Bacterial Spore: From Molecules to Systems is an ambitious effort at consolidating this body of research in a way that highlights the biological diversity of bacterial spore formers, their industrial and medical applications, and fundamental mechanistic insights gained from their study in a way that is accessible to both the novice and expert microbiologist.”

Incidences such as the 2014 Ebola epidemic in West Africa and the 2015 appearance of Zika in Brazil provide dramatic evidence of the continued ability of microbes to emerge, spread, adapt, and threaten global health. The challenge facing infectious disease specialists and public health professionals is to improve and find new diagnostic, therapeutic, and prevention strategies.

The editors of the 10th installment of the Emerging Infections series have compiled the perspectives of leading infectious disease experts into 22 chapters that provide important updates on a broad range of emerging and reemerging bacterial, viral, parasitic, and fungal infectious diseases in the United States and globally. In addition to focusing on MERS, Ebola virus disease, chikungunya, and Zika virus disease, Emerging Infections 10 explores the global threat of antimicrobial resistance in reviews on carbapenem-resistant Enterobacteriaceae, multiply-resistant gonococcal infections, non-typhoidal Salmonella infections, and artemisinin-resistant Plasmodium falciparum malaria. Topics include both recently- and long-recognized diseases that pose challenges for the clinical, laboratory, research, public health, and animal health communities.

Emerging Infections 10 presents new and emerging strategies to prevent, control, and eradicate infectious diseases and guides readers to the primary literature where they can explore individual topics in greater depth. This book is a valuable reference for professionals in microbiology, epidemiology, public health, and clinical and veterinary medicine.

“The renowned editors and the authors they enlisted teach us about microbial threats in our rapidly changing world. From frogs to people, from viruses to fungi, they detail compelling stories about urgent problems and suggest solutions. Emerging Infections 10 is an education at the front-lines of a perennial struggle.”

“In keeping with the longstanding tradition of this series, the 10th edition of Emerging Infections continues with timely updates of the newest information on the ever changing landscape of new infections of public health importance.”

With more than 1,000 posts and 2 million views, the esteemed blog Small Things Considered has been sparking the imagination of microbiologists for an entire decade. Throughout the years, Elio Schaechter and his team of dedicated bloggers have shared exciting, unexpected, and unusual stories from the microbial world.

In the Company of Microbes is a carefully selected treasure chest of wise, amusing, and even profound statements about the ubiquity and relevance of the microbial world. Schaechter, other past ASM Presidents, and distinguished microbiologists from around the globe reflect on personal, sometimes historic interactions with microbes and unexpected discoveries, each essay conveying the excitement and sense of surprise that microbiology holds for them. This is the reason that Small Things Considered is a scientific and social media phenomenon that has impacted scientists at every stage of their careers and shared the magic of microbes with world.

Join Schaechter in discovering a never-ending pageant of astounding variations on the theme of microbial life. Enjoy!

“ Since Elio Schaechter’s blog, Small Things Considered, first appeared 10 years ago, I have looked forward to each post. I smiled, laughed, and always learned something new about the microbial world. Elio’s style is uniquely engaging and makes microbiology come alive. This book captures all the best of Elio’s magic. It is a must-read for students of microbiology of any age.”

For years, the ASM Undergraduate Educator Community has sought a repository of multiple-choice questions for monitoring learning in the microbial sciences. ASM Sample Questions in Microbiology was specifically developed by educators to meet that need.

Containing more than 200 multiple-choice and true/false questions, ASM Sample Questions in Microbiology covers the breadth and depth of microbiology content suitable for undergraduates in introductory and/or general microbiology. The questions are adaptable for all upper-level microbial sciences courses, from clinical, food, and industrial and environmental microbiology to virology and immunology.

Each question includes the correct response and is aligned with core themes and fundamental concepts about the microbial world as identified in the ASM Recommended Core Curriculum Guidelines. Additionally, most questions require critical thinking (levels 3-5 in Bloom’s Learning Taxonomy). The sample questions also include instructor notes.

More than 50 volunteer educators, from community colleges and undergraduate institutions to doctoral degree–granting institutions, responded to nationwide solicitations for assessment questions. All questions were subjected to two rounds of review, editorial review for scope and clarity and blinded peer review for scientific accuracy and high-quality pedagogy.

The book provides access to a Word file that can be manipulated for a range of classroom activities including pre- and post-test questions, in-class discussion using clickers, or written, high-stakes midterm and final exams.

Revised by a collaborative, international, interdisciplinary team of editors and authors, this edition includes the latest applications of genomics and proteomics and is filled with current findings regarding infectious agents, leading-edge diagnostic methods, laboratory practices, and safety guidelines. This seminal reference of microbiology continues to set the standard for state-of-the-science laboratory practice as the most authoritative reference in the field of microbiology.

“What do you do when your MALDI-TOF reports Sneathia sanguinegens and the doctors is asking what it is, or when you are asked whether a Borrelia recurrentis infection can be treated with ceftriaxone, or whether Coxsackieviruses cause hepatitis? You turn to “THE source” for clinical microbiology information - The Manual of Clinical Microbiology. Whether on your tablet or on the bench; it has what you need.”

—Fred C. Tenover, Vice President, Scientific Affairs, Cepheid

“The Manual of Clinical Microbiology is the key resource for understanding what, why, and how in clinical microbiology.
It is truly a must-have document for guiding current practice.”

Explore the remarkable discoveries in the rapidly expanding field of plasmid biology

Plasmids are integral to biological research as models for innumerable mechanisms of living cells,
as tools for creating the most diverse therapies, and as crucial helpers for understanding the dissemination of microbial populations.
Their role in virulence and antibiotic resistance, together with the generalization of “omics” disciplines, has recently ignited a new wave of interest in plasmids.

This comprehensive book contains a series of expertly written chapters focused on plasmid biology, mechanistic details of plasmid function,
and the increased utilization of plasmids in biotechnology and pharmacology that has occurred in the past decade.

Plasmids: Biology and Impact in Biotechnology and Discovery serves as an invaluable reference for researchers in the wide range of fields and disciplines
that utilize plasmids and can also be used as a textbook for upper-level undergraduate and graduate courses in biotechnology and molecular biology.

"The study and utilization of plasmids is experiencing renewed interest. This book is a comprehensive and illustrative source where readers can find the latest advances in all aspects of plasmids, from the basic understanding of their biology to their utilization as tools in the modern laboratory."

"Plasmids: Biology and Impact in Biotechnology and Discovery compiles information on the recent progress achieved in the field of Plasmid Biology. It constitutes a wealth of inextinguishable knowledge, and is an important reference for all scientists working in the expanding and interconnected world of modern biology."

—Prof. Manuel Espinosa, Professor 'ad honorem' at the Centro de Investigaciones Biológicas from the Consejo Superior de Investigaciones Científicas

Marcelo E. Tolmasky is a Professor at the Department of Biology, California State University, Fullerton, and the Director of the Center for Applied Biotechnology Studies. He did his PhD at the Fundación Instituto Leloir under the mentorship of Luis F. Leloir and his postdoctoral training in Jorge H. Crosa’s laboratory at the Oregon Health & Sciences University, where he studied virulence and antibiotic resistance plasmids in Gram-negatives. His current research focuses on several basic and applied aspects of plasmid-mediated multidrug resistance and virulence. He was a coeditor of the book Enzyme-Mediated Resistance to Antibiotics: Mechanisms, Dissemination, and Prospects for Inhibition (ASM Press).

Juan C. Alonso is a Research Professor at the Centro Nacional de Biotecnología (CSIC), Madrid, Spain. He did his PhDs at the School of Veterinary Science and Exact and Natural Sciences under the mentorship of Eduardo Zaccardi and Oscar Grau, respectively. He completed his postdoctoral training studying plasmid and chromosomal horizontal gene transfer in Bacillus subtilis in Thomas Trautner’s lab at the Max-Planck-Institute for Molecular Genetics, Berlin, Germany. Current research in his laboratory focuses on genomic stability in Firmicutes. Through genetic, cytological, biochemical, and biophysics approaches, the long-term goal is to define the molecular steps in the dynamic process of homologous recombination and DNA segregation.

State-of-the-art reviews covering major aspects of antibodies and intervention against infectious diseases.

The connection between antibodies and infectious diseases has spawned entire related fields of study. Antibodies for Infectious Diseases presents perspectives from leading research scientists and summarizes the amazing progress in this area into a single definitive source.

Providing a broad survey of the most important aspects of the field of antibodies for infectious diseases, this book

presents general features pertaining to structure, function, isotype, and the role of complement in antibody function

examines the role of antibodies in antimicrobial immunity with specific targets

details new methods for expression of monoclonal antibodies, in plants or by transfer of antibody genes for in vivo expression in treated subjects

Antibodies for Infectious Diseases is a comprehensive reference for researchers, pharmaceutical developers, and health care professionals on the status of the development of antibody-based therapies for treating infectious diseases. It is also useful as supplemental reading for upper level life sciences students.

James E. Crowe, Jr. is an immunologist and board-certified pediatric infectious diseases specialist. Dr. Crowe is the Ann Scott Carell Chair and Professor of Pediatrics, Pathology, Microbiology and Immunology, and Director of the Vanderbilt Vaccine Center. He is an Elected Member of the Institute of Medicine and a Fellow of the American Association for the Advancement of Science, the American Academy of Microbiology, and the American Society for Clinical Investigation. Dr. Crowe’s laboratory has a broad portfolio of work in the area of viral immunology and cell biology focused on discovery of the genetic and structural determinants of neutralization of viruses by human antibodies and immune mechanisms important to development of new vaccines.

Diana Boraschi is the Research Director at the CNR Institute of Protein Biochemistry. She is actively involved in high education activities, in particular in Africa. Dr. Boraschi’s studies focus on the role of macrophages and IL-1 cytokines in the innate/inflammatory response against infections and tumors and their possible involvement in chronic inflammatory and autoimmune pathologies.

Rino Rappuoli is the Global Head of Research and Development at Novartis Vaccines. Dr. Rappuoli has worked on several molecules that became part of, or are near to becoming, licensed vaccines. He is an elected member of the U.S. National Academy of Sciences and of the European Molecular Biology Organization.

An examination of the research and translational application to prevent and treat biofilm-associated diseases

In the decade since the first edition of Microbial Biofilms was published, the interest in this field has expanded, spurring breakthrough research that has advanced the treatment of biofilm-associated diseases. This second edition takes the reader on an exciting, extensive review of bacterial and fungal biofilms, ranging from basic molecular interactions to innovative therapies, with particular emphasis on the division of labor in biofilms, new approaches to combat the threat of microbial biofilms, and how biofilms evade the host defense.

Chapters written by established investigators cover recent findings, and contributions from investigators new to the field provide unique and fresh insights. Specifically,

Microbial Biofilms provides

state-of-the-art research in the field of bacterial and fungal biofilms

detailed descriptions of the in vitro and in vivo models available to evaluate microbial biofilms

future areas of research and their translational and clinical applications

Microbial Biofilms is a useful reference for researchers and clinicians. It will also provide insight in the dynamic field of microbial biofilms for graduate and postgraduate students.

“Biofilms influence human health and agriculture, and sustain diverse ecosystems. This second edition of Microbial Biofilms provides a masterful overview of critical topics central to fungal and bacterial biofilms by celebrated experts in the field. It is a must read for any professional seeking basic or advanced knowledge of microbial biofilms.”

— David S. Perlin, Professor and Executive Director, Public Health Research Institute, New Jersey Medical School-Rutgers University

Mahmoud A. Ghannoum is a Professor in the Department of Dermatology at Case Western Reserve University and University Hospitals Case Medical Center and Director of the Center for Medical Mycology.
Dr. Ghannoum’s investigations include the biology, pathogenesis, and resistance of clinically important fungi Candida, Aspergillus, and Cryptococcus, and his work has recently focused on the oral microbiome, fungal species, and human disease. He has published more than 300 peer-reviewed articles in the field of biofilms, microbial pathogenesis, and preclinical in vitro and in vivo evaluations of antimicrobials.

Matthew Parsek is a Professor of Microbiology at the University of Washington, School of Medicine at Seattle. Dr. Parsek’s research focuses on microbial community behaviors and their relationship to disease.

Marvin Whiteley is the Director of the Center for Infectious Disease and a fellow of the John Ring LaMontagne Chair in Infectious Diseases and Global Health at the University of Texas at Austin. Dr. Whiteley’s research focuses on understanding how microbes within infection sites cooperate to cause disease.

Pranab Mukherjee is an Assistant Professor in the Department of Dermatology at Case Western Reserve University. Dr. Mukherjee has extensive experience in fungal pathogenesis and microbial biofilms, including analyses of their biochemical and molecular pathways using systems biology approaches. He also studies the human microbiome (bacteriome and mycobiome) in health and disease, including HIV-infection, corneal infections, inflammatory bowel disease, eczema, and psoriasis. He advises pharmaceutical companies in antifungal drug development .

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Every speck of dust, drop of water, and grain of soil and each part of every plant and animal contain their own worlds of microbes.

Designed as a key text for upper-level undergraduates majoring in microbiology, genetics, or biology, Principles of Microbial Diversity provides a solid curriculum for students to explore the enormous range of biological diversity in the microbial world. Within these richly illustrated pages, author and professor James W. Brown provides a practical guide to microbial diversity from a phylogenetic perspective in which students learn to construct and interpret evolutionary trees from DNA sequences. He then offers a survey of the “tree of life” that establishes the necessary basic knowledge about the microbial world. Finally, the author draws the student’s attention to the universe of microbial diversity with focused studies of the contributions that specific organisms make to the ecosystem.

Principles of Microbial Diversity fills an empty niche in microbiology textbooks by providing an engaging, cutting-edge view of the “microbial zoo” that exists around us, covering bacteria, archaea, eukaryotes, and viruses.

Praise for Principles of Microbial Diversity

“We desperately needed a book that climbs the big tree, branch by branch, written both for undergraduates and as a reference. Principles of Microbial Diversity is that book!” -Jo Handelsman, Howard Hughes Medical Institute Professor, Frederick Phineas Rose Professor, Department of Molecular, Cellular and Developmental Biology, Yale University

“What an absolutely fabulous book! Jim Brown captures the excitement and transformative impact that microbial diversity has brought to the field of microbiology in a text appropriate for students. Principles of Microbial Diversity belongs on every microbiologist’s bookshelf.” -Hazel A. Barton, Associate Professor of Biology, Associate Professor of Geosciences, University of Akron

James (Jim) W. Brown’s lasting interest in microbiology was sparked by a single lecture on microbial diversity in an undergraduate microbiology class at Ball State University and by the announcement in that class of the discovery of an entirely new kind of living thing, the "archaebacteria." He went on to earn his MS in Microbiology at Miami University and his PhD in the Molecular, Cellular, and Developmental Biology program at The Ohio State University. Jim developed and continues to teach senior-level undergraduate lecture and lab courses in microbial diversity at North Carolina State University (NCSU), which are the genesis of this textbook. He was awarded the NCSU Alumni Association Distinguished Undergraduate Professor award in 2014.

Whether contracted through contaminated food or a trip to the petting zoo, disease-causing E. coli is a major human health threat

Most Escherichia coli strains live harmlessly in the intestines of healthy humans and animals, but virulent strains—the enterohemorrhagic E. coli (EHEC) and certain Shiga toxin–producing E. coli (STEC)—cause life-threatening infections, with young children and the elderly most at risk. EHEC and STEC are easily transmitted through contaminated water or food and, more rarely, through contact between animals and people. Thus, controlling outbreaks of these pathogens is a concern for the infectious disease community and the food industry.

Covering a diverse array of topics, including microbial pathogenesis, disease pathophysiology, food safety, genetic analysis, veterinary microbiology, epidemiology, and environmental microbiology, Enterohemorrhagic Escherichia coli and Other Shiga Toxin-Producing E. colipresents the most current, relevant research overview from a multidisciplinary, international group of expert authors concerned with tracking, deciphering, and dealing with the diseases caused by EHEC and STEC.

Editors Vanessa Sperandio and Carolyn J. Hovde have updated and expanded the scope of the previous edition, Escherichia coli O157:H7 and Other Shiga Toxin-Producing E. coli Strains. Useful as a textbook for advanced courses in microbiology, food safety, infectious disease, or microbial pathogenesis, this new volume is also a valuable reference for research scientists, clinicians, health professionals, policy makers, and food safety professionals.

"This volume, edited by two experts in the field, Vanessa Sperandio and Carolyn Hovde, encompasses the current state of knowledge of the epidemiology and pathogenesis of EHEC and defines the challenges to improved disease control. Comprehensive and timely, this is a must read for those engaged in E. coli research."

Vanessa Sperandio is a Professor in the Departments of Microbiology and Biochemistry at the University of Texas Southwestern Medical Center. Her research investigates chemical, stress, and nutritional signaling at the interface among the mammalian host, beneficial microbiota, and invading pathogens. A fellow of the American Academy of Microbiology and the 2015 recipient of the ASM Eli Lilly and Company-Elanco Research Award, Dr. Sperandio serves on the editorial boards of mBio, Infection and Immunity, Journal of Bacteriology, and Gut Pathogens.

Carolyn J. Hovde is a University Distinguished Professor who has served as the Idaho NIH INBRE Director since 2006. Dr. Hovde’s laboratory studies E. coli O157:H7 with a primary focus on understanding the relationship between this human pathogen and its silent reservoir, healthy cattle. A Fellow of the American Association for the Advancement of Science and winner of the ASM Carski Foundation Distinguished Undergraduate Teaching Award, she is President of the National Association of IDeA Principal Investigators (NAIPI).

Groundbreaking thinking on how bacterial metabolism is foundational to pathogenesis.

For too long, bacterial metabolism and bacterial pathogenesis have been studied as separate entities. However, the scientific community is beginning to realize that not only are bacterial nutrient acquisition and utilization essential for pathogenesis, but that interfering with the pathogen-specific metabolic pathways used during infection can regulate virulence factor expression and might lead to effective breakthroughs in a variety of treatments.

Editors Paul Cohen and Tyrrell Conway, who pioneered the use of metabolic mutants in competitive colonization assays, an approach now widely used to investigate the nutrition of pathogens in vivo, are uniquely qualified to advance our knowledge of this integrative field of research. They convened a group of contributors who are breaking new ground in understanding how bacterial metabolism is foundational to pathogenesis to share their expert perspectives and outlook for the future.

a wide range of diseases and both Gram-positive and -negative bacteria that serve as model systems for in vitro and in vivo investigations

intracellular, respiratory, and enteric pathogens

pathogen-specific nutrient acquisition in hosts

mechanisms of host-driven metabolic adaptation by pathogens

metabolic regulation of virulence gene expression

Useful for specialists in bacterial pathogenesis and specialists in metabolism as well as molecular biologists, physicians, veterinarians, dentists, graduate and undergraduate students, and laboratory technicians, Metabolism and Bacterial Pathogenesis is also essential reading for scientists studying the microbiome.

“Within these pages, leading experts in the field summarize research on a timely topic that connects research on the pathogenesis of infectious diseases to bacterial physiology. Metabolism and Bacterial Pathogenesis is great addition for bacteriologists from both medical schools and colleges of biological sciences.”

—Andreas Bäumler, Professor and Vice Chair of Research, Department of Medical Microbiology and Immunology, UC Davis School of Medicine

Paul Cohen recently retired from his professorship in the Department of Cell and Molecular Biology at the University of Rhode Island. During most of his career, Dr. Cohen conducted research on various strains of E. coli, and is currently involved in studies related to E. coli colonization in the large intestines of mice. He is coeditor of Colonization of Mucosal Surfaces (ASM Press).

Tyrrell Conway is Professor and Head of the Department of Microbiology and Molecular Genetics at Oklahoma State University. Among his several scientific discoveries, Dr. Conway is the co-inventor of U.S. Patent number 5,000,000 for genetically engineering E. coli to make biofuels, and he published the first DNA microarray paper on E. coli.

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Principles of Virology is the leading virology textbook because it does more than collect and present facts about individual viruses. Instead, it facilitates an understanding of basic virology by examining common processes and principles. Using a set of representative viruses to illustrate viral complexity and, this rational approach enables students to understand viral reproduction, and provides the tools for future encounters with new or understudied viruses.

This new edition is fully updated to represent the rapidly changing field of virology. A major new feature of this edition is the inclusion of 26 video interviews with leading scientists who have made significant contributions to the field of virology. These in-depth interviews, conducted by Vincent Racaniello, provide the background and thinking that went into the discoveries or observations connected to the concepts being taught in this text. Students will discover the personal stories and twists of fate that led the scientists to work with viruses and make their seminal discoveries.

Principles of Virology is ideal for teaching the strategies by which all viruses reproduce, spread within a host, and are maintained within populations. It is appropriate for undergraduate courses in virology and microbiology as well as graduate courses in virology and infectious diseases. Volume I: Molecular Biology covers the molecular biology of viral reproduction. Volume II: Pathogenesis & Control addresses the interplay between viruses and their host organisms. The two volumes can be used for separate courses or together in a single course. Each includes a unique appendix, glossary, and links to Internet resources such as websites, podcasts, and blogs.

Help your students save on textbooks! Email us and receive a coupon to share with your students for 20% off of the purchase of a print copy.

Principles of Virology is the leading virology textbook because it does more than collect and present facts about individual viruses. Instead, it facilitates an understanding of basic virology by examining common processes and principles. Using a set of representative viruses to illustrate viral complexity and, this rational approach enables students to understand viral reproduction, and provides the tools for future encounters with new or understudied viruses.

This new edition is fully updated to represent the rapidly changing field of virology. A major new feature of this edition is the inclusion of 26 video interviews with leading scientists who have made significant contributions to the field of virology. These in-depth interviews, conducted by Vincent Racaniello, provide the background and thinking that went into the discoveries or observations connected to the concepts being taught in this text. Students will discover the personal stories and twists of fate that led the scientists to work with viruses and make their seminal discoveries.

Principles of Virology is ideal for teaching the strategies by which all viruses reproduce, spread within a host, and are maintained within populations. It is appropriate for undergraduate courses in virology and microbiology as well as graduate courses in virology and infectious diseases. Volume I: Molecular Biology covers the molecular biology of viral reproduction. Volume II: Pathogenesis & Control addresses the interplay between viruses and their host organisms. The two volumes can be used for separate courses or together in a single course. Each includes a unique appendix, glossary, and links to Internet resources such as websites, podcasts, and blogs.

An exploration of the raw power of genetic material to refashion itself to any purpose…

Virtually all organisms contain multiple mobile DNAs that can move from place to place, and in some organisms, mobile DNA elements make up a significant portion of the genome. Mobile DNA III provides a comprehensive review of recent research, including findings suggesting the important role that mobile elements play in genome evolution and stability.

Editor-in-Chief Nancy L. Craig assembled a team of multidisciplinary experts to develop this cutting-edge resource that

covers the specific molecular mechanisms involved in recombination, including a detailed structural analysis of the enzymes responsible

presents a detailed account of the many different recombination systems that can rearrange genomes

examines the tremendous impact of mobile DNA in virtually all organisms

Mobile DNA III is valuable as an in-depth supplemental reading for upper level life sciences students and as a reference for investigators exploring new biological systems. Biomedical researchers will find documentation of recent advances in understanding immune-antigen conflict between host and pathogen. It introduces biotechnicians to amazing tools for in vivo control of designer DNAs. It allows specialists to pick and choose advanced reviews of specific elements and to be drawn in by unexpected parallels and contrasts among the elements in diverse organisms.

Mobile DNA III provides the most lucid reviews of these complex topics available anywhere.

“Mobile DNA III provides a one-stop-shop for anyone wanting to keep abreast of current understanding of the activity of these elements and the enzymes that they encode. It should will be an invaluable resource for some time to come.”

— David Finnegan, Institute of Cell Biology, University of Edinburgh, King's Buildings.

Nancy L. Craig, is an Investigator with the Howard Hughes Medical Institute and a Professor in the Department of Molecular Biology & Genetics at the Johns Hopkins University School of Medicine. Dr. Craig is a member of the National Academy of Sciences and a Fellow of the American Association for the Advancement of Science, American Academy of Microbiology, and the American Academy of Arts and Sciences.

A collection of essays focusing on the importance of ethics consideration within the scientific community

Research misconduct and other ethical violations in science continue to be matters of concern to the international research community. Perspectives on Research Integrity addresses the need to provide ethics training early and often—in classroom settings and throughout a researcher’s career.

Written by ethics and education experts, Perspectives on Research Integrity presents an enlivened discussion on the globally important topics of responsible conduct of research (RCR) and ethics education. It synthesizes the current state of RCR and considers future directives and requirements.

A resource for how to teach RCR, Perspectives on Research Integrity was developed specifically for educators, researchers, and RCR offices to train responsible researchers. It is also useful as ancillary readings for students in any course involving research ethics.

Help your students save on textbooks! Email us and receive a coupon to share with your students for 20% off of the purchase of a print copy.

Principles of Virology is the leading virology textbook because it does more than collect and present facts about individual viruses. Instead, it facilitates an understanding of basic virology by examining common processes and principles. Using a set of representative viruses to illustrate viral complexity and, this rational approach enables students to understand viral reproduction, and provides the tools for future encounters with new or understudied viruses.

This new edition is fully updated to represent the rapidly changing field of virology. A major new feature of this edition is the inclusion of 26 video interviews with leading scientists who have made significant contributions to the field of virology. These in-depth interviews, conducted by Vincent Racaniello, provide the background and thinking that went into the discoveries or observations connected to the concepts being taught in this text. Students will discover the personal stories and twists of fate that led the scientists to work with viruses and make their seminal discoveries.

Principles of Virology is ideal for teaching the strategies by which all viruses reproduce, spread within a host, and are maintained within populations. It is appropriate for undergraduate courses in virology and microbiology as well as graduate courses in virology and infectious diseases. Volume I: Molecular Biology covers the molecular biology of viral reproduction. Volume II: Pathogenesis & Control addresses the interplay between viruses and their host organisms. The two volumes can be used for separate courses or together in a single course. Each includes a unique appendix, glossary, and links to Internet resources such as websites, podcasts, and blogs.

Serves as an essential resource for all clinical laboratories, from the physician’s office to hospital clinical labs to the largest commercial reference laboratories, providing practical information in the fields of medicine and healthcare, clinical pathology, and clinical laboratory management, for practitioners, managers, and individuals training to enter these fields.

"Virtually
all details of management and management skills are discussed and, while many
management books lack a compelling reason for reading, this one should be a
standard in every laboratory manager’s office library. ... Get it for yourself,
give it as a gift—but make it a staple for the manager. "

One Health—the interdisciplinary approach that considers the fundamental connections between human, animal, and ecosystem health—is critical for the future control of infectious diseases.

One Health is a global strategy that represents a paradigm shift in how we must respond to the threat of infectious diseases. Rather than identifying and treating infections in isolation, One Health focuses on a collaborative, holistic surveillance of the environment, animals, and humans to predict an outbreak of disease before it happens. This approach accelerates biomedical advances by integrating environmental, veterinary, and human medical science in understanding the development and transmission of infectious diseases.

In One Health: People, Animals, and the Environment, editors Ronald M. Atlas and Stanley Maloy have compiled 20 chapters written by interdisciplinary experts that present core concepts, compelling evidence, successful applications, and the remaining challenges of One Health approaches to thwarting the threat of emerging infectious disease. Topics include

insight into the mechanisms of microbial evolution toward pathogenicity

causes behind the emergence of antibiotic resistance

new technologies and approaches for public health disease surveillance

political and bureaucratic strategies for promoting the global acceptance of One Health

This book is a valuable resource for physicians, veterinarians, environmental scientists, microbiologists, public health workers and policy makers, and others who want to understand the interdependence of human, animal, and ecosystem health.

“This book provides a comprehensive overview of how the One Health concept needs to bring together human and veterinary and scientific communities to understand the events that underlie the emergence of new infectious challenges. Should be mandatory reading for anyone interested in zoonotic diseases.”

— Christopher A. Hunter, Professor and Chair, Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania

Ronald M. Atlas, PhD, is Professor of Biology at the University of Louisville and has served as president of the American Society for Microbiology and as chair of the Board of Directors of the One Health Commission.

Stanley Maloy, PhD, is Dean of the College of Sciences and Professor of Microbiology at San Diego State University, and a past president of the American Society for Microbiology.

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This widely adopted textbook provides the essential content and skill-building tools for teaching the responsible conduct of scientific research. Scientific Integrity covers the breadth of concerns faced by scientists: protection of animal and human experimental subjects, scientific publication, intellectual property, conflict of interest, collaboration, record keeping, mentoring, and the social and ethical responsibilities of scientists. Learning activities and resources designed to elucidate the principles of scientific integrity include

Dozens of highly relevant, interactive case studies for discussion in class or online

Supported by a companion website that allows ready access to relevant online content

Documents including published rules of conduct, sample experimentation protocols, and patent applications

The new edition of Scientific Integrity responds to significant recent changes―new mandates, policies, laws, and other developments―in the field of responsible conduct of research. Dr. Macrina plants the seeds of awareness of existing, changing, and emerging standards in scientific conduct and provides the tools to promote critical thinking in the use of that information.Scientific Integrity is the original turnkey text to guide the next generations of scientists as well as practicing researchers in the essential skills and approaches for the responsible conduct of science.

“Scientific Integrity should be on the bookshelf of the entire research community. With the ever-growing ability of science to positively impact society, education in the responsible conduct of research is increasingly important for all members of the community, from students through faculty, staff, and administrators.”

―Timothy Donohue, Professor of Bacteriology, University of Wisconsin-Madison, and Director, Great Lakes Bioenergy Research Center

Human evolution and history are inextricably connected to a world of microbes. Over thousands of years, a global landscape of food and drink has rested fundamentally on beneficial microorganisms and the process of fermentation.

In Cheese and Microbes, editor Catherine W. Donnelly presents perspectives from internationally renowned experts on the essential role of these wonderful organisms in transforming milk into an extraordinary galaxy of cheeses. The chapters provide a scientific overview of the association of microbes with cheese through the lens of select cheese varieties that result due to surface mold ripening, internal mold ripening, rind washing, cave aging, and surface smear rind development.

Cheese and Microbes

Explains the transformation of milk to cheese and how sensory attributes of cheese are evaluated

Discusses the regulations governing cheesemaking, both in the United States and abroad, that ensure safety

Explores how the tools of molecular biology provide new insights into the microbial complexity of cheeses

Examines the biodiversity of traditional cheeses as a result of traditional practices

Presents research on the stability of the microbial consortia of select traditional cheese varieties

Cheese and Microbes is for cheesemakers, scientists, students, and cheese enthusiasts who wish to expand their knowledge of cheeses and traditional foods.

Explore cheese from its early discovery to the complex interaction between cultures and milk to why stinky cheeses smell to the aging process…all governed by microbes. Whether you are a cheese lover, a scientist, or both, the book is a remarkable resource to understand this delicious transformation.. —Jeff Roberts, Owner/President, Cow Creek Creative Ventures; Adjunct Faculty, New England Culinary Institute; and Visiting Faculty, University of Gastronomic Sciences

Dr. Catherine W. Donnelly is a professor of nutrition and food science at the University of Vermont. She served as the Associate Director of the Vermont Institute for Artisan Cheese from 2004 to 2013. Recognized by colleagues for her many contributions to improving Listeria detection, Dr. Donnelly is widely regarded as an international Listeria expert and has published numerous articles and delivered hundreds of presentations on this bacterial pathogen. Her current scholarly interests include investigation of the microbiological safety of aged raw milk cheeses.

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Cases in Medical Microbiology and Infectious Diseases challenges students to develop a working knowledge of the variety of microorganisms that cause infections in humans. This valuable, interactive text will help them better understand the clinical importance of the basic science concepts presented in medical microbiology or infectious disease courses.

The cases are presented as “unknowns” and represent actual case presentations of patients the authors have encountered. Each case is accompanied by several questions to test knowledge in four broad areas including the organism’s characteristics and laboratory diagnosis; pathogenesis and clinical characteristics of the infection; epidemiology; and prevention and, in some cases, drug resistance and treatment.

This new fourth edition includes:

An entirely new section, “Advanced Cases,” which includes newly recognized disease agents as well as highly complex cases where the interaction of the immune system and human pathogens can be more closely examined

A revised “Primer on the Laboratory Diagnosis of Infectious Diseases” that reflects the increasing importance of molecular-based assays

42 new cases that explore the myriad advances in the study of infectious disease in the past decade

32 updated cases that reflect the current state of the art as it relates to the organism causing the infection

This textbook also includes tools to assist students in solving the cases, including a table of normal values, glossary of medical terms, and figures illustrating microscopic organism morphology, laboratory tests, and clinical symptoms. Cases in Medical Microbiology and Infectious Diseases is a proven resource for preparing for Part 1 of the National Board of Medical Examiners Exam and an excellent reference for infectious disease rotations.

A comprehensive collection of perspectives by experts in mycobacterial molecular biology

Tuberculosis, caused by Mycobacterium tuberculosis, causes one in four avoidable deaths in the developing world and kills more adults than malaria, AIDS, and all tropical diseases combined. TB is now considered a global health emergency; a distinction never accorded another disease. Although the field of mycobacterial genetics has expanded dramatically, with investigations into new areas of mycobacterial growth, replication, metabolism, physiology, drug susceptibility, and virulence, most of the problems in tuberculosis control that existed in 2000 are still with us today.

The good news is that the advances in mycobacterial genetics are beginning to be reflected in exciting recent developments. New diagnostic approaches can determine drug resistance within a few hours, promising new drugs are progressing through the pipeline and into the clinic, and a range of newly developed vaccines are being evaluated. It is an exciting time as the fruits of 30 years of intensive genetic investigation are finally beginning to emerge.

Written by leading experts in the field, Molecular Genetics of Mycobacteria, Second Edition:

Discusses key areas of current research in mycobacterial genetics.

Explains the genetics of the physiology, metabolism, and drug sensitivities of Mycobacterium tuberculosis.

Provides a resource to learn about genetic approaches for manipulating Mycobacterium tuberculosis.

Presents an invaluable handbook for anyone interested in mycobacterial genetics or wishing to enter the field of research into Mycobacterium tuberculosis or other mycobacterial species.

This book is an invaluable resource for anyone interested in the molecular genetics and molecular biology of mycobacteria.

“Molecular Genetics of Mycobacteria is an extraordinary book. It includes chapters from virtually every major scientific contributor to the genetic understanding of mycobacteria. For anyone entering the field or seeking to learn about fundamental genetic and molecular aspects of mycobacteria, this book is a necessity.”

– Barry R. Bloom, Harvard University Distinguished Service Professor and Former Dean, Harvard School of Public Health

Graham F. Hatfull, PhD, is a professor of biological sciences, Eberly Family Professor of Biotechnology, and a Howard Hughes Medical Institute professor at the University of Pittsburgh. Dr. Hatfull studies the molecular genetics of the mycobacteria and their phages. He leads integrated research and education programs to discover and sequence new phages and uses phage genomic information to develop tools to manipulate and understand M. tuberculosis. Dr. Hatfull began work on the mycobacteriophages in 1988 and has collaborated with Dr. Jacobs since that time, leading to collaborative grant funding and many coauthored publications.

William R. Jacobs Jr., PhD, is a professor of microbiology and immunology and a professor of genetics at the Albert Einstein College of Medicine and an investigator with the Howard Hughes Medical Institute. He has studied mycobacterial diseases, including leprosy and tuberculosis, for the last 34 years. Dr. Jacobs’ research interests have focused on understanding the mechanisms of drug-resistant tuberculosis, immune evasion of M. tuberculosis, development of recombinant BCG vaccine vectors, and development of reporter phages for rapidly assessing drug susceptibilities in M. tuberculosis isolates. He is working to understand the persistence phenotype of M. tuberculosis in order to develop improved chemotherapies and vaccines. Dr. Jacobs and Dr. Hatfull have collaborated on the genetic analysis of phages, which has led to integration-proficient vectors and improved phage vectors as tools for clarifying the molecular biology of M. tuberculosis.

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A brand-new, groundbreaking textbook that illustrates how biotechnology has radically changed the way we think about health care.

Biotechnology is delivering not only new products to diagnose, prevent, and treat human disease but entirely new approaches to a wide range of difficult biomedical challenges. Because of advances in biotechnology, hundreds of new therapeutic agents, diagnostic tests, and vaccines have been developed and are available in the marketplace.

In this jargon-free, easy-to-read textbook, the authors demystify the discipline of medical biotechnology and present a roadmap that provides a fundamental understanding of the wide-ranging approaches pursued by scientists to diagnose, prevent, and treat medical conditions.

Medical Biotechnology is written to educate premed and medical students, dental students, pharmacists, optometrists, nurses, nutritionists, genetic counselors, hospital administrators, and individuals who are stakeholders in the understanding and advancement of biotechnology and its impact on the practice of modern medicine.

“Medical Biotechnology will be an essential textbook for senior undergraduate and postgraduate courses in biotechnology in many universities.”

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An in-depth presentation of the oral ecosystem and its role in human health and disease

In the second edition of best-selling textbook Oral Microbiology and Immunology, an international panel of editors presents an in-depth, comprehensive understanding of the oral ecosystem and its role in human health and disease. Written specifically for dental students, dental practitioners, and healthcare professionals, Oral Microbiology and Immunology cohesively details the ecology, virulence, molecular biology, and immunogenicity of oral bacteria, viruses, and fungi and examines their interfaces with host cells and secretions.

This new edition addresses the technological and conceptual advances that have increased our understanding of the etiology of oral diseases and the nature of pathogenic mechanisms and the host response, including:

Genome sequencing of a bacterium or a community of bacteria.

Knockout mice deficient in specific components of both the innate and adaptive immune systems.

High-resolution and 3D imaging techniques of communities growing in biofilms and the intimate interactions between microbes and host cells.

“The editors of the second edition are eminent players in oral microbiology, molecular genetics, and immunology and have invited several young investigators to contribute and upgrade chapters from the first edition. The second edition is a significant improvement, providing detailed current information on a breadth of topics, including molecular techniques for bacterial identification, population genetics of oral bacteria, infection-driven oral diseases, and control of oral diseases.”

—Dr. Paul Kolenbrander, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health (retired)

“This textbook is an easy read and makes the information clear for student comprehension. The fact that “Key Points” are highlighted at the end of each chapter really drives home and summarizes many of the pertinent concepts. The tables, figures, graphics, etc., help to support the information disseminated to the students.”

Conceived by a team of authors with decades of classroom and laboraory experience, the Color Atlas of Medical Bacteriology includes more than 730 brilliant, four-color images of common pathogenic bacteria and descriptions of the methods used to identify them, including microscopic and phenotypic characteristics, colonial morphology, and biochemical properties.

Each chapter, organized by pathogen and taxonomic group, begins with a brief introduction that provides a contextual framework for the images. This second edition embraces the latest developments in molecular biology methodology in the diagnostic laboratory with a new chapter examining the breadth and possibilities of these new techniques. Also, in light of the alarming emergence of antibiotic resistance, antimicrobial susceptibiliy testing is addressed in another new chapter. The final chapter on stains, media, and reagents details the most common menthods and biochemical reactions used in the identification of pathogenic bacteria. The book's hundreds of illustrations, of typical stains, colony morphologies, and biochemical reactions of bacteria most frequently encountered in the clinical laboratory, have been thouroughly updated.

A valuable illustrative supplement for lectures and laboratory presentations, this easy-to-use atlas was written for laboratorians, clinicians, students, and anyone interested in the field of diagnostic medical bacteriology.

The Color
Atlas of Medical Bacteriology is a good reference book that is fairly
complete with wonderful images. It would be a welcome addition to the
bookshelves of any teaching institution or clinical microbiology
laboratory.

– Clinical
Infectious Diseases review of the first edition, written in 2006

The approach centers on the most-studied bacteria, Escherichia coli and Bacillus subtilis. Additionally, examples from other medically, ecologically, or biotechnologically significant bacteria are covered throughout the text. The revised text reflects exciting developments in the field of bacterial molecular genetics and its relationship to other fields, including genetics, biotechnology, and bioengineering.

Perfect for advanced undergraduate and graduate-level courses, each chapter contains

Chapters authored by renowned researchers and practitioners detail the latest scientific knowledge and concerns of food microbiology and offer descriptions of the most advanced techniques for detecting, analyzing, tracking, and controlling microbiological hazards in food.

Specifically, this new edition addresses:

The rapid advancement of our basic knowledge of foodbourne microorganisms, e.g. the differentiation between virulent and avirulent strains

The expansion of the types of foods associated with foodbourne disease events, e.g., the increased recognition of dried foods and fresh produce as vehicles of pathogenic microorganisms

The continues globalization of the food industry, and the search for new prevention and intervention technologies to enhance the quality and safety of foods.

This advanced text is an indispensable resource for research microbiologists, graduate students, and professors of food microbiology courses.

“This book provides a detailed, sophisticated exploration of the rich science of food microbiology. It balances the importance of the practical and applied needs of food microbiology with the inherent needs for scientific exploration of the fundamental issues of genetics, growth, survival, and control of prokaryotic and eukaryotic foodborne agents.”

—Kali Kniel, Department of Animal and Food Sciences, University of Delaware, Newark

“The editors and contributors to the text have done an excellent job of capturing, integrating, synthesizing, and presenting the scientific knowledge we have today, as well as forecasting and providing thoughtful directions for the future. This book provides the reader with a thorough knowledge base, when needed to inform actions today, new risk management strategies for tomorrow, and stimulus for research.”

Michael P. Doyle is a Regents Professor and Director, Center for Food Safety, University of Georgia, Griffin. Dr. Doyle received his BS, MS, and PhD from the University of Wisconsin-Madison in bacteriology/food microbiology. He has published more than 500 scientific papers on food microbiology and food safety topics and has given more than 800 invited presentations at national and international scientific meetings. Dr. Doyle is a Fellow of the American Academy of Microbiology, the American Association for the Advancement of Science, the Institute of Food Technologists, and the International Association for Food Protection and is a member of the Institute of Medicine of the National Academies.

Robert L. Buchanan is Director of the University of Maryland's Center for Food Safety and Security Systems. Dr. Buchanan received his BS, MS, MPhil, and PhD in Food Science from Rutgers University, and postdocroral training in mycotoxicology at the University of Georgia. He has more than 35 years of experience in teaching, conducting research in food safety, and working at the interface between science and public health policy, first in academia, then in government service at both USDA and FDA, and most recently at the University of Maryland's College of Agriculture and Natural Resources. Dr. Buchanan has published extensively on a broad range of subjects related to food safety and is one of the codevelopers of the widely used USDA Pathogen Modeling Program.

Regulation of Bacterial Virulence features 28 review chapters, written by leading investigators in the field, encompassing the most current, innovative insights regarding established regulatory systems as well as emerging new paradigms in host­pathogen confrontations. It also

Provides insights into global control and the switch between distinct infectious states (acute versus chronic).

Reflects on how the regulation of intracellular lifestyles and the response to stress can ultimately have an impact on the outcome of an infection.

Highlights and examines emerging regulatory mechanisms of special significance.

Regulation of Bacterial Virulence is an ideal resource for students, researchers, and faculty interested in how the mechanisms of gene regulation ultimately affect the out­come of an array of bacterial infectious diseases.

Hardcover, 620 pages, full-color illustrations, index.

"This book nicely integrates descriptions of general regulatory themes with specific examples of how genes are regulated in particular pathogens, providing an interesting and useful un­derstanding of the regulation of bacterial virulence."

— Stanley Maloy, Dean, College of Sciences, San Diego State University

"To understand gene regulation is to understand how bacteria think. Vasil and Darwin have recruited a distinguished group of contributors to explore the myriad ways in which pathogenic bacteria perceive and respond to diverse host environments. This volume is highly recommended for experienced investiga­tors and newcomers alike."

Michael L. Vasil obtained his PhD from the University of Texas Southwestern Medical School in 1975. He is currently a professor of microbiology at the University of Colorado School of Medicine. He has written or coauthored over 150 published works. Dr. Vasil is a member of the American Academy of Microbiology and was elected to the Academy of Medical Educators at the University of Colorado.

Andrew J. Darwin obtained his PhD from the University of Birmingham in 1993. He is currently an associate pro­fessor at the
New York University School of Medicine. His interests include the molecular genetic analysis of bacterial physiology and virulence.
Dr. Darwin is currently a member of the editorial boards of Infection and Immunity, the Journal of Bacteriology, and Molecular Microbiology as well as an associate editor of the forthcoming ASM Press periodical Microbiology Spectrum.

Expert storytellers weave together the science, technological advances, medical urgencies, and human stories that chronicle the development of the field of diagnostic virology.

Follows historical discoveries that defined viruses and their roles in infectious diseases over a century of developments, epidemics, and molecular advances, and continuing into the 21st century with AIDS, HIV, and a future that in no way resembles the past.

Features the great names and personalities of diagnostic virology, their contributions, their associations, and their challenges to prove findings that some considered fantasy.

Describes how scientists applied revolutionary technologies, studying viruses, first in animal models and tissue culture and progressing to molecular and genetic techniques.

Appeals to the pioneer and adventure-seeker who is interested in how a scientific field evolves.

“This is a
wonderful read for anyone interested in understanding the roots and evolution
of virology and immunology. Booss and August bring the history of virology to
life in a gripping narrative that is entertaining as well as informative.”

─ W. Ian
Lipkin, MD, John Snow Professor of Epidemiology and Director, Center for
Infection and Immunity, Mailman School of Public Health; Professor of Pathology
and Neurology, College of Physicians & Surgeons, Columbia University.

“To Catch a Virus provides a lively and
entertaining historical tour de force
of diagnostics virology, from mummies to molecules. It describes clearly how we have advanced
from the discovery of filterable viruses through animal models, cell culture
techniques, serological approaches, and microscopy to our current ability to
identify molecular footprints of infection.
I highly recommend it.”

The neglected tropical diseases (NTDs) are the most common infections of the world’s poor, but few people know about these diseases and why they are so important. This second edition of Forgotten People, Forgotten Diseases provides an overview of the NTDs and how they devastate the poor, essentially trapping them in a vicious cycle of extreme poverty by preventing them from working or attaining their full intellectual and cognitive development.

Author Peter J. Hotez highlights a new opportunity to control and perhaps eliminate these ancient scourges, through alliances between nongovernmental development organizations and private-public partnerships to create a successful environment for mass drug administration and product development activities. Forgotten People, Forgotten Diseases also:

Addresses the myriad changes that have occurred in the field since the previous edition.

Describes how NTDs have affected impoverished populations for centuries, changing world history.

Considers the future impact of alliances between nongovernmental development organizations and private-public partnerships.

Forgotten People, Forgotten Diseases is an essential resource for anyone seeking a roadmap to coordinate global advocacy and mobilization of resources to combat NTDs.

“Like Dr.
Hotez, I have struggled with how to best get the word out about our need to
address NTDs and their link to poverty.
Now he has provided us all with a remarkable tool, a book for people
without an extensive scientific or medical background. Forgotten
People, Forgotten Diseases is an excellent “one-stop” primer about NTDs”

─ From the
Foreward by Soledad O’Brien

Peter J. Hotez, MD, PhD, is the
founding Dean of the National School of Tropical Medicine and Professor of
Pediatrics and Molecular Virology & Microbiology at Baylor College of
Medicine. He is also President of the
Sabin Vaccine Institute; Director of the Texas Children’s Hospital Center for
Vaccine Development; Texas Children’s Hospital Endowed Chair of Tropical
Pediatrics; and Baker Institute Fellow in Disease and Poverty at Rice
University.

The asm2013 Abstract CD-ROM provides access to 2,800 accepted abstracts from asm2013. The CD’s user friendly interface and customized search functionality will allow you to sort through abstracts by invited speakers, authors, topical categories, keywords, and late-breakers. In addition to the research from this year’s event, the ICAAC 2012 Abstract CD-ROM also offers access to over 3,000 abstracts from asm2012.

Written by the world’s leading scientists in Arctic
and Antarctic microbiology, Polar
Microbiologysheds new light on
the microbial ecology and physiology of the Earth’s polar regions and offers a
survey of what is known and not known
about the microbial inhabitants of polar environments.

Polar Microbiology addresses the
adaptations and physiology of cold-adapted microorganisms, explores the ecological
role that polar microbial communities play in biogeochemical cycling, and
examines the challenges that polar and subpolar microorganisms encounter.

The study of polar microbiology offers insights into the fundamentals
of life on earth as well as critical environmental issues such as climate
change, ozone depletion, and elemental cycling. Designed for a general
microbiology audience as well as for scientists and students in all areas of
biology and geomicrobiology, Polar
Microbiologyhighlights and
analyzes the significance of recent findings and set forth avenues for further
research.

“An exciting introduction to the rapidly emerging field of cold biosphere microbiology, this book provides a compelling overview of how microbial life survives and even thrives in the coldest regions of our planet, and the implications for potential life on other icy worlds.”

“Polar Microbiology
capsulizes a wide swath of knowledge about microbial life in the cold. This
book will help launch new understanding of the perplexing behaviors of polar
microorganisms—organisms that drive ecosystems critical to the functioning of
the earth.”

Robert V. Miller, PhD, is
Regents Professor and Head of the Microbiology and Molecular Genetics
Department at Oklahoma State University (OSU). Since earning his doctorate at
the University of Illinois, he has been awarded 32 research grants, published
200 works, including 5 co-authored books, and trained 16 Doctoral and 7 Masters
students. Miller is a former Cardiff
University Distinguished International Scholar and frequent invited lecturer on
polar microbiology.

Lyle Whyte, PhD, Associate
Professor and Canada Research Chair in the Department of Natural Resource
Sciences at McGill University, leads the Canadian Astrobiology Training
Program. He completed his doctorate at the University of Waterloo and has
served as a Research Officer at the Biotechnology Research Institute, National
Research Council of Canada. His research examines microbial biodiversity,
activity, and ecology in polar ecosystems, especially permafrost and unique
cold saline springs, in the emerging field of cryomicrobiology, the exploration
of the low-temperature limits of microbial life.

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The newly updated and expanded Food Microbiology: An Introduction, Third Edition includes expert perspectives on parasites, viruses and prions, and non-thermal processes. The text incorporates instructors' input to further clarify complex topics in the field of food microbiology and encourages students to venture beyond memorization and think critically to gain a broader conceptual understanding of food microbiology and acquire the understanding and skills necessary to ensure the safety of tomorrow's food supply.
The book presents explicit learning goals to focus students on the core principles of food microbiology and introduces the genetics and molecular mechanisms important for the understanding of foodborne microbes.

Intracellular Pathogens I: Chlamydiales is a current review of basic research on Chlamydiales biology and pathogenesis in one comprehensive volume. The book details the scientific knowledge about how these obligate intracellular bacteria invade, survive and replicate inside eukaryotic cells and also describes the spectrum of disease caused by an infection including protective and pathologic immune responses.

Intracellular Pathogens I: Chlamydiales describes the latest developments, including genomics and biomathematical modeling, and progress towards genetic tools and a vaccine. The book serves as a significant research book for scientists, physicians, medical students, public health professionals, epidemiologists, biocomputational scientists and government policy makers.

A current review of basic research on Rickettsiales biology and pathogenesis in one comprehensive volume. The text details the scientific knowledge about how these obligate intracellular bacteria invade, survive and replicate inside eukaryotic cells. It also describes the spectrum of disease caused by an infection and the role of vectors in tramsmission, and discusses protective and pathologic immune responses and establishment of persisten infection. In addition, the text describes the latest developments including genomics and progress in vaccine development.

The title serves as a significant research book for scientists, physicians, medical students, public health professionals, epidemiologists, biocomputational scientists and government policy makers.

Inspired by a 2009 colloquium on microbial evolution convened at the Galapagos Islands, Microbes and Evolution celebrates Charles Darwin and his landmark book On the Origin of Species. Through this collection of 40 first-person essays written by microbiologists with a passion for evolutionary biology, you'll come to understand how their thinking and career paths in science were influenced by Darwin's seminal work.

The essays in Microbes and Evolution explore how the evidence of microbial evolution deeply and personally affected each scientist. Prepare to be suprised and delighted with their views on the importance of evolutionary principles in the study of a variety of aspects of life science, from taxonomy, speciation, adaptation, social structure, and symbiosis to antibiotic resistance, genetics, and genomics.

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Written as a text for one-semester microbiology courses, the third edition of the highly acclaimed Bacterial Pathogenesis draws together the latest research to help students explore the mechanisms by which bacterial pathogens cause infections in humans and animals. It features two additional authors who offer new points of view to ensure that all facets of the field are thoroughly explored. Readers will discover the strategies that bacterial pathogens use to survive and multiply within their hosts as well as the strategies that hosts use to fend off infections. At the same time, the text’s engaging style, illustrative examples, and thought-provoking exercises convey the excitement and fun of scientific discovery.

Completely revised and updated, this third edition features a new organization that dispenses with separate chapters dedicated to individual bacterial pathogens. Instead it focuses on core principles based on the growing understanding of the underlying similarities among pathogens and their mechanisms of action. In addition, readers familiar with the previous edition will find much new material. For example, there is new coverage of key findings on the mechanisms of bacterial secretion, toxins, and regulation.

Study questions at the end of each chapter challenge students to probe more deeply into the issues covered. This edition also offers new problems that immerse students in the discovery process. These problems present actual research data, asking students to interpret the data and then devise new experiments that would help build their understanding.

New to the Third Edition

Presents new paradigms that unify concepts in the field of bacterial pathogenesis

Challenges students to interpret actual research data and design new experiments

Explores the latest findings on the mechanisms of bacterial secretion, toxins, and regulation

Expands coverage of the role of normal microbial populations of the human body in health and disease

Includes two new authors offering additional perspectives and points of view

Now in its Fifth Edition, the highly acclaimed Medically Important Fungi continues to set the standard in its field. Clinical laboratories around the world depend on this for its superb illustrations of microscopic morphology that initiate step-by-step guidance along with textual descriptions, instructions on laboratory methods and on preparation and applications of useful media, and specific references for further information; all of which enable the user to approach the identification of medically important fungi with confidence. The unique organization of Medically Important Fungi compares similar organisms side by side, using photomicrographs, exquisite line drawings, and comparative tables to illustrate critical characteristics and distinctions. The book avoids technical jargon in favor of clear, straightforward explanations that enable everyone—from novices to experienced lab technologists—to support best medical care with accurate identification of fungi.

Medically Important Fungi begins with a helpful guide to using the book and then divides the process of identification into four sections. Part I discusses the direct microscopic examination of clinical pathology specimens, while Part II extensively covers the identification of individual species in culture. Part III—new to this edition—presents the basics of the molecular approach to fungal identification from classic methods to the latest techniques, including explanation of terminology used, amplification and sequence- and non-sequence-based methods, applications of DNA sequencing, and commercial platforms. Part IV carefully directs readers through essential laboratory procedures, staining methods, and media.

The book also features extensive color plates illustrating tissue reactions to fungal infection, characteristic fungal morphology both in stained tissue and as growing colonies, and concludes with an illustrated glossary, a newly expanded bibliography, and a list of useful websites.

New to the Fifth Edition

Comprehensive update and revision of all material

Adds a section explaining molecular techniques used for fungal identification

Includes five new organisms plus updated information on all other organisms discussed in the book

The 10th edition of the Manual of Clinical Microbiology continues to set the standard for state-of-the-science laboratory practice as the most authoritative reference in the field. This 10th edition represents the collaborative efforts of 22 editors and more than 260 authors from around the world, all experienced researchers and practitioners in medical and diagnostic microbiology. Together, they have brought the manual fully up to date, producing a remarkable work of two volumes, nine sections, and 149 chapters that is filled with the latest research findings, infectious agents, methods, practices, and safety guidelines.

Electronic Only, 2,630 pages, color illustrations, indexes.

Are you interested in purchasing a site license to the Manual of Clinical Microbiology, 10th Edition for your institution or lab? Contact books@asmusa.org for more information!

Over the course of his career, John Roth has inspired his students and colleagues not only with his achievements, but also with his sense of adventure and joy in solving difficult puzzles in bacterial genetics. In addition, he has instilled in them his unique, rigorous scientific approach. Endlessly curious, he is forever diagramming ideas, developing them into models, designing experiments to test those models, and then evaluating the results in order to develop new models and tests. Along the way, he encourages his colleagues’ feedback, engaging them at every step of the scientific process.

This book has been written and edited by colleagues and former students of John Roth, many of whom are also leaders and pioneers in the field of bacterial genetics. It provides a complete overview of the entire field of bacterial genetics, helping the reader to understand how the field has evolved through the years. Moreover, the book enables everyone to be inspired by and to learn from John Roth’s achievements and contributions to bacterial genetics.

Initial chapters introduce the reader to John Roth and his impact on science. Subsequent chapters offer valuable lessons in both the history and science of bacterial genetics. The authors take the reader behind the scenes for a look at some of the most important triumphs and mishaps that have occurred on the path to discovery. The final chapter, written by John Roth himself, offers a fascinating look into the future. Progressing through the book, readers will gain valuable insights into how scientists think, how scientific ideas evolve, and how scientists interact.

The second edition of Molecular Microbiology: Diagnostic Principles and Practice presents the latest molecular diagnostic techniques to support clinical care and basic and clinical research. The authors-all experienced researchers and diagnosticians-have conducted a comprehensive review and evaluation of this rapidly evolving field and provide the new material in an easy-to-read summary format. Moreover, the book offers a broad range of practical advice, such as determining the appropriate type and quantity of a specimen, releasing and concentrating the targets, and eliminating inhibitors.

Molecular Microbiology not only examines techniques to detect individual pathogens, but also explores the growing trend toward a systems approach for diagnosing infectious diseases, with chapters covering gastrointestinal infections, sepsis, meningitis, and encephalitis. In short, this text not only encapsulates the current state of the science, but also points to new avenues for research that will broaden the application and usefulness of molecular diagnostics.

The second edition of the highly acclaimed Bacterial Stress Responses incorporates and reviews the vast number of new findings that have greatly advanced the understanding of bacterial stress responses in the decade since the publication of the first edition. Readers will discover how this improved understanding not only enhances our knowledge of all cellular regulation at the molecular level, but also provides new ammunition in the fight against pathogens and helps optimize the use of bacteria in biotechnology.

The first section explores general regulatory principles, including the latest findings from genomics studies. In the second and third sections readers will learn how much more researchers have discovered about both specific and general stress responses. Next, the fourth section reviews how stress responses affect the interactions between bacteria and host cells. The fifth section describes bacterial stress responses in different niches and communities, with an emphasis on extreme environments. The final section examines how our growing understanding of bacterial stress responses can be used to better combat bacterial infection with antibiotics and improve biofuel production and bioremediation.

All chapters have been contributed by leaders and pioneers in their respective fields and then carefully edited to ensure conciseness and clarity. With its coverage of a broad range of model organisms as well as biotechnologically, medically, and environmentally relevant bacteria, this new edition fully encapsulates our understanding of bacterial stress responses. Moreover, it serves as a springboard for new investigations and new applications.

Since its first clinical appearance in an 1890s case report, Cryptococcus has dramatically advanced as a human fungal pathogen: it now infects approximately 1 million individuals per year, resulting in more than 600,000 annual mortalities, including one-third of all AIDS-associated deaths.

Featuring more than 100 expert authors from around the world, this book offers the full range of scientific and clinical perspectives needed to create this unique, comprehensive overview of Cryptococcus. It covers both the Cryptococcus neoformans and Cryptococcus gattii species, examining in detail the life cycle, pathophysiology, molecular biology, genetics, genomics, epidemiology, immunology, and clinical management of this encapsulated yeast. Among the 44 chapters, readers will find several in-depth discussions of the C. gattii outbreak that began on Vancouver Island in 1999 and then spread into the mainland of Canada and the United States, causing infections in both humans and animals.

This book’s detailed, thorough reviews of all the latest advances and progress in the field set a new standard for publications dedicated to a single fungal pathogen. While the book is dedicated to Cryptococcus, it does draw analogies to other pathogenic fungi and, more broadly, to other microbial pathogens. Moreover, this volume demonstrates why Cryptococcus has become a model system for the study and understanding of fungal pathogenesis. As a result, molecular biologists, microbiologists, public health officials, epidemiologists, and infectious disease clinicians will all find this clearly written, carefully referenced, and all-inclusive book to be a highly valuable resource.

The Fecal Bacteria offers a balanced, integrated discussion of fecal bacteria and their presence and ecology in the intestinal tract of mammals, in the environment, and in the food supply. This new volume covers their use in examining and assessing water quality in order to offer protection from illnesses related to swimming in or ingesting contaminated water, in addition to discussing their use in engineering considerations of water quality, modeling, monitoring, and regulations. Fecal bacteria are additionally used as indicators of contamination of ready-to-eat foods and fresh produce. The intestinal environment, the microbial community structure of the gut microbiota, and the physiology and genomics of this broad group of microorganisms are explored in the book.

With contributions from an internationally recognized group of experts, the book integrates medicine, public health, environmental, and microbiological topics in order to provide a unique, holistic understanding of fecal bacteria. Moreover, it shows how the latest basic science and applied research findings are helping to solve problems and develop effective management strategies. For example, readers will discover how the latest tools and molecular approaches have led to our current understanding of fecal bacteria and enabled us to improve human health and water quality.

The Fecal Bacteria is recommended for microbiologists, clinicians, animal scientists, engineers, environmental scientists, food safety experts, water quality managers, and students. It will help them better understand fecal bacteria and use their knowledge to protect human and environmental health. They can also apply many of the techniques and molecular tools discussed in this book to the study of a broad range of microorganisms in a variety of habitats.

With an approach that covers the range from basic research to clinical applications, The Immune Response to Infection examines the mechanisms of both the innate and adaptive immune systems as they relate to infection and disease. The book not only explores the underlying mechanisms of immunity, but also the many sequelae of host-pathogen interactions, ranging from the sterile eradication of the invader, to controlled chronic infection, to pathologic corollaries of the host-pathogen crosstalk. It also explores the pathogenesis of certain autoimmune disorders and cancers that are induced by infectious agents but then become independent of the infection process.

Most chapters consider host-pathogen interactions in the context of the broad divisions of the microbial world-viruses, bacteria, and parasites-and do not confine their discussions to any individual pathogen. However, the book does dedicate special attention to the three major killer diseases-HIV/AIDS, tuberculosis, and malaria-and the influenza viruses. All of the chapters consider the special attributes that make each pathogen difficult to control, building a thorough discussion of current prophylactic and therapeutic vaccines and the prospects for future vaccine development.

By reviewing the entire spectrum of immunology as it relates to infectious agents, this book underscores the important relationship between molecular biology and clinical immunology. It is recommended equally for researchers and students who focus on the pathogen and those who examine the immune system: immunologists, molecular microbiologists, and clinicians specializing in infectious disease.

After more than four decades of working on the frontlines in the war against malaria, author Irwin W. Sherman is uniquely qualified to present this chronicle of the search for medicines to conquer malaria. The book not only reviews the history of antimalarial medicines, it also explains the hurdles that lie ahead in the discovery and development of effective treatments and control strategies. Moreover, it provides new perspectives on the creative process of drug discovery as well as the challenges of overcoming drug resistance.

Magic Bullets To Conquer Malaria provides a historical overview of the medicines that have been used to treat malaria. It recounts how these drugs were discovered, how they have been used, and why they have failed to eradicate this disease. In addition, readers will learn about the use of larvicides, bednets, and DDT as well as recombinant DNA and monoclonal antibodies to block malaria transmission from mosquitoes to humans.

Each year, there are some 350 million to 500 million cases of malaria, killing between one million and three million people, the majority of whom are children in sub-Saharan Africa. This book will help microbiologists, parasitologists, pharmacologists, medicinal chemists, biochemists, physicians, and drug researchers better understand what has been done and what still needs to be done in the battle against malaria. Even readers with a limited background in chemistry and biology will find that the book’s clear, conversational style enables them to make sense of 300 years of malarial drug research, from quinine to today’s drugs and beyond.

The concept of using stable isotopes to label and track microbes and metabolites of interest is a very recent development in microbial ecology. This comprehensive, carefully edited book, featuring contributions from world leaders in the development and application of these technologies, is the first to present stable isotope probing (SIP) and its related technologies in a single volume.

Divided into three parts, the book begins with methodology, guiding researchers through the basic, tested, and proven protocols including DNA, RNA, protein, and phospholipid fatty acid (PLFA) SIP, from concept and history through detailed methodology, troubleshooting, and interpretation, to optimal and future uses. Next, the book explores the important and emerging applications of SIP in environmental microbiology, ranging from bioremediation and gene mining to carbon tracking and gut microflora function. The book concludes with explorations of further elegant isotope labeling technologies such as Raman-FISH, NanoSIMS, and isotope arrays.

Stable Isotope Probing and Related Technologies is recommended not only for students and researchers in environmental microbiology, but also for those who can apply these cutting-edge technologies to such fields as genomics, biotechnology, and medical microbiology. The book also provides readers with access to the current literature, making it the ideal starting point for investigating, developing, and implementing stable isotope technologies.

Genomic sequencing initiatives from around the world have resulted in the complete sequencing of a large number of food- and waterborne pathogens, including most of the bacterial agents associated with significant disease in human populations. In this contributed work, the authors review these genome sequencing initiatives, explaining how they continue to build our understanding of the ecology, adaptation, and evolution of individual pathogens. In addition, the authors explain how our growing understanding of pathogen genomics has the potential to help ensure the safety of global food and water supplies.

Each chapter focuses on a specific food- or waterborne pathogen that represents a major public health threat. Moreover, each chapter has been written by one or more authors who have made major contributions to the genomic discovery of the particular pathogen. These authors explore all the findings, potential applications, and new questions that have arisen from genomic discovery efforts. They also examine how global trends such as climate change, growing human populations, and increasing levels of pollution are stressing the ecosystems that food- and waterborne pathogens encounter, forcing them to adapt.

Genomes of Foodborne and Waterborne Pathogens not only presents the latest findings from genome sequencing studies: it also translates this information into both scientific and public health opportunities. It is therefore recommended not only for microbiology and genomics researchers but also for public health officials, regulators, food scientists, and other professionals tasked with protecting our food and water supplies from dangerous pathogens.

Oral bacteria are the first human microbiome to encounter the food we eat. To date, most research has focused on the role of oral bacteria in the development and progression of caries and periodontal disease; however, little is known about the microbial communities that maintain a healthy oral cavity. This book, Oral Microbial Communities: Genomic Inquiry and Interspecies Communication, helps readers understand how multispecies microbial communities function to maintain and promote oral health as well as disease. It explores the immense opportunities presented by readily accessible, genetically tractable, genome-sequenced oral species that naturally form multispecies communities.

Emphasizing the use of genomic inquiry to probe questions, Oral Microbial Communities examines multispecies community interactions, spatiotemporal organization, and gene function. Readers will find coverage of all the major microbe species currently under investigation by leading oral microbiologists. In particular, the book highlights model systems that study oral bacterial interactions, including biofilm growth using saliva as the source of nutrition.

The book’s 25 chapters have been contributed by an international team of leading oral microbiologists. As a result, readers will gain a deeper understanding of the role of the oral microbiome in health, oral disease, and systemic disease. Moreover, they will gain a new appreciation of how oral microbial communities form, evolve, and communicate the intricacies of multispecies community life.

Population Genetics of Bacteria: a Tribute to Thomas S. Whittam explores the field of bacterial population genetics by highlighting the work of the late Thomas S. Whittam, one of the field’s leading innovators and pioneers. Dr. Whittam helped develop a statistical understanding of the abundance and distribution of genetic diversity within populations of the model organism Escherichia coli. Best known for his work with enterohemorrhagic E. coli O157:H7, a foodborne pathogen, he developed the STEC Center, an acclaimed collection of pathogenic E. coli strains that continues to support the research of clinical scientists, evolutionary biologists, microbiologists, and population geneticists.

Focusing on the application of bacterial population genetics to pathogenic E. coli, this book brings together a compilation of research projects and ideas stemming from Dr. Whittam’s work. Readers gain a broad perspective on the historical development of bacterial population genetics, which underscores how Dr. Whittam’s research has shaped and defined the field. Next, individual contributions examine E. coli from ecological, evolutionary, and clinical perspectives. Finally, the book provides a detailed explanation of how population genetics principles have guided the investigations of the lethal O157:H7 lineage.

Each chapter has been written by one or more leading experts in bacterial population genetics who have been inspired to expand upon the investigations of Dr. Whittam. Readers will discover how the methodologies that Dr. Whittam used to study pathogenic E. coli and O157:H7 now serve as models to investigate many other pathogenic bacterial populations.

Growing public concern over the safety of our food supply has fueled the research and development of new methods to detect foodborne pathogens as quickly and as early as possible. This reader-friendly reference examines the latest proven rapid foodborne pathogen detection methods currently used. Organized by food commodities, this unique book enables readers to choose the most effective and efficient method, assemble the necessary resources, and implement the method seamlessly, avoiding common pitfalls.

Rapid Detection, Characterization, and Enumeration of Foodborne Pathogens is organized into seven sections. The first two sections review the latest laboratory technologies designed to accelerate test results, and explain the issues that labs need to consider in order to effectively implement rapid detection methods. The next four sections are organized according to commodity and food production lines, enabling readers to easily find the best pathogen detection methods for their needs. For each food line, the book sets forth the rapid methods that can detect important target pathogens. The final section looks to the future, detailing research needs and emerging areas of rapid detection of foodborne pathogens.

More than 85 experts from worldwide research centers provide guidelines for faster, user-friendly, and cost-effective foodborne pathogen detection. Their advice is based not only on a thorough review of the current literature, but also their own first-hand laboratory experience. As a result, readers can confidently turn to this book to minimize the risk of pathogen-contaminated foods reaching consumers.

One-third of the world’s human population is currently infected with tuberculosis. Tuberculosis remains epidemic, causing close to two million deaths each year. Most of these deaths occur in developing nations; however, developed nations also struggle with tuberculosis, contending with such growing challenges as drug resistance, immigration, immunosuppression, and nontuberculous mycobacterial infection. Nearly 30 years after the publication of the first edition, the Sixth Edition of this comprehensive reference gathers the most current science and tools available in the fight against tuberculosis, enabling readers to fully understand the underlying mechanisms of tuberculosis and correctly diagnose and manage the disease.

Tuberculosis and Nontuberculous Mycobacterial Infections is divided into three sections. Section I presents basic concepts of epidemiology, pathophysiology, diagnosis, medical and surgical therapy, drug-resistant tuberculosis, vaccines, and tuberculosis in enclosed populations. Section II covers both classic and more recent clinical manifestations of tuberculosis infection. Separate chapters address every organ system as well as issues unique to pregnancy, infants and children, HIV infection, organ transplantation and immune reconstitution inflammatory syndrome. Section III explores nontuberculous mycobacterial infections, including a detailed discussion of the clinical syndromes produced by these organisms.

All the chapters have been written by leading experts whose experience ranges from basic and clinical research to bedside medicine.

Over the past 15 years, the use of modern molecular biological approaches has radically advanced our understanding of nitrification processes. With chapters contributed by leading experts in the field, Nitrification fully reviews all the latest research findings on microbes involved in conventional aerobic nitrification, anaerobic ammonia oxidation, and related processes.

The book begins with an overview of the current state of the field. Next, the four principal groups of nitrifying microbes are examined in separate sections, covering conventional aerobic bacterial ammonia oxidizers, recently discovered aerobic archaeal ammonia oxidizers, anaerobic ammonia-oxidizing planctomycetes, and nitrite-oxidizing bacteria. Within each section, readers can gather current information on the ecology, phylogeny, biochemistry, molecular biology, and genomics of each group of microbes. The authors also discuss the latest industrial applications of nitrification and anammox processes. The final section of the book explores the ecology of nitrification in marine, freshwater, soil, and wastewater environments.

By reviewing all aspects of nitrification in one place, Nitrification introduces novices to the field and brings experienced researchers up to date with all the latest perspectives. Extensive references at the end of each chapter guide readers to the field’s growing body of primary research, making this book the ideal starting point for any investigation of nitrifying microbes.

Yeast Research, which was originally concerned with improving wine-making and brewing processes, has played a major role in the development of a number of modern scientific disciplines. In the 20th century, investigations of yeasts laid the foundations for mitochondrial genetics and cell cycle research. Today, thousands of people are engaged in research on yeasts, studying their physiology, metabolism, genetics, and molecular biology and developing new applications for industry and medicine. The book describes the historical background of this important work.

This book reviews the history of yeast research, beginning with fermentation research at the end of the 18th century. It traces our growing understanding of yeasts and their role in the evolution of microbiology, biochemistry, cytology, and genetics, and it includes an account of research on medical yeasts. Readers will learn how findings in yeast research were used to overcome complex problems and to develop currently accepted scientific concepts and methods.

Author James Barnett has worked on yeasts in the laboratory for 50 years and accordingly emphasizes experimental evidence, reproducing many figures from the original researchers’ work as well as illustrations of the equipment they used. The book is enlivened with images of many of the scientists and offers accounts of notable incidents in the lives of some of them.

More than 2,400 references are included, and there are many direct quotations from these sources. With its detailed discussions of the development of theory, methods, and techniques, Yeast Research: a Historical Overview serves as a key resource for anyone teaching or learning microbiology, biochemistry, or general biology.

The study of microbe-metal interactions is a burgeoning research area within environmental biogeochemistry. It has led to many major innovations and discoveries, including the development of microbial fuel cells, pili that function as “nanowires,“ and new, enhanced approaches to bioremediation. This publication, dedicated to the memory of geomicrobiology pioneer Terry Beveridge, reviews the current state of the science in the field. In addition, it examines emerging developments and applications and forecasts future research directions.

Microbial Metal and Metalloid Metabolism is divided into three sections: Environments, Processes, and New Technologies. Readers will find a broad range of current topics and approaches in microbe-metal research, including microbial fuel cells, unique microbial physiology, genomics, proteomics, and transcriptomics. The book offers chapters to introduce novices to the field as well as chapters to bring advanced investigators fully up to date with the latest state-of-the-science findings and applications.

All the chapters have been authored by recognized leaders and innovators in the field. Their contributions are based on a thorough review of the current literature and their own first-hand research experience, making the book an ideal reference for investigators interested in the microbial metabolism of metals and metalloids. The book is also recommended as a text for graduate courses in microbial physiology, microbial ecology, and applied and environmental microbiology.

From Hippocrates to Lillian Wald-the stories of scientists whose work changed the way we think about and treat infection.

Describes the genesis of the germ theory of disease by a dozen seminal thinkers such as Jenner, Lister, and Ehrlich.

Presents the “inside stories” of these pioneers’ struggles to have their work accepted, which can inform strategies for tackling current crises in infectious diseases and motivate and support today’s scientists.

Relevant to anyone interested in microbiology, infectious disease, or how medical discoveries shape our modern understanding

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Based on the author’s experiences teaching virology for more than 35 years, Virology: Molecular Biology and Pathogenesis enables readers to develop a deep understanding of fundamental virology by emphasizing principles and discussing viruses in the context of virus families. Moreover, individual virus families are examined within the context of the Baltimore classification system, a key unifying theme that allows readers to assume basic facts about the replication strategy of a virus based on the nature of its genome.

The first chapter provides an historical overview, followed by a chapter introducing the principles of animal virus classification and the Baltimore classification system. The next chapter explores the various modes of virus infection and disease. Chapter 4 then considers host defenses against microorganisms and viral countermeasures to subvert those host defenses.

Armed with a solid foundation in basic principles, readers move on to eighteen subsequent chapters, each one dedicated to a particular virus family. These chapters detail the organization of the viral genome and its pattern of expression, with additional discussions covering viral structure, entry, assembly, release, and associated medical issues.

The flow of chapters in Virology constitutes a continuous narrative in which key principles are regularly reintroduced to show how they apply in different contexts. This emphasis on principles coupled with the text’s clear, straightforward writing style enables upper-level undergraduate and graduate students as well as professionals to grasp core principles of virology with ease.

Key Features

Organization by virus family within the context of the Baltimore classification system provides a strategic framework for mastering the principles of virology

Provides a uniform organization and logical flow of chapters as well as a consistent, accessible writing style

Highlight boxes review fundamental molecular and cellular biology, introduce pioneers in the field of virology, and address serious public policy issues

Antibiogram is the first English edition of the original French work published in 1985. Over the last twenty years, new categories of antibiotics have entered the market and numerous forms of resistance have appeared and multiplied. The revised volume comprehensively incorporates all of the major developments that have occurred in the field since the publication of the first edition.

The book is comprised of four sections: the antibiogram principles and methods, the antibiogram of the principal bacterial groups, technical specifications for antibiotics case studies, and appendixes and definitions.

With contributions made by more than fifty authors, this new volume is intended primarily for bacteriologists and biologists working in laboratory settings, for infectious disease specialists, for researchers in the pharmaceutical industry, and also for students.

Key Features

Provides a comprehensive compendium for antibiotherapy

Includes many chapters offering expanded coverage of new categories of antibiotics

Offers numerous illustrations to help the reader easily understand the topics discussed

Features contributions by more than fifty international experts working in the field

Presents appendixes that include everything from definitions and acronyms to information on industry web sites and literature

Pathogens and Toxins in Foods: Challenges and Interventions offers a farm-to-table approach to food safety that enables readers to control microbial pathogens and toxic agents at all stages of the food supply chain. The book begins with chapters that help readers understand the characteristics of specific pathogens and toxins, the illnesses they cause, and the factors such as food processing operations that affect their survival and growth in food products.

Further, the chapters in the book explore the most recent advances in biological, chemical, and physical interventions to control food-borne hazards during pre-harvest, harvest, food processing, and in retail ready-to-eat foods and food service operations. Also included are chapters that discuss the latest methods to rapidly detect food-borne pathogens as well as the implementation of comprehensive food safety management systems.

Each chapter has been written by one or more leading experts in the field of food safety. Their advice is based on a thorough investigation of the literature as well as their own first-hand experience. In short, by drawing from hundreds of sources, this book offers food safety professionals a unique, single reference containing the latest understanding of food-borne hazards as well as the latest methods to detect and control their incidence.

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From hypothesis to discovery, I, Microbiologist enables students to develop all the basic skills and experience all the wonderment of conducting a meaningful research project from start to finish-all within a one-semester laboratory course. Specifically, students learn to reconstruct the phylogeny of a unique soil-based microbial community by analyzing 16S rRNA genes. In the process, students discover new microbes, novel sequences, and previously unknown phenotypes.

Each of the text’s seven units features experimental protocols and essential background information, giving students the tools and context needed to formulate hypotheses, conduct experiments, and gather data. Written assignments associated with the readings for each unit challenge students to analyze experimental data, interpret results, and evaluate conclusions. This coursework gives students an opportunity to practice scientific process skills that can be applied to their own projects. As their research progresses, students master basic techniques in microbiology, molecular biology, and bioinformatics, learning how to troubleshoot problems that typically arise in collaborative investigations.

This text was written for undergraduate courses in microbiology, microbial ecology, molecular evolution of microbes, and microbial genomics. The entire research project can be completed in as few as 10 weeks, with students divided into groups and with tasks divided among group members. In short, this text gives students an unparalleled experience, preparing them to take on research projects in any working lab.

Key Features

Features detailed, well constructed experimental protocols that enable students to generate results in a short period of time

Develops the skills that students need to initiate, conduct, and interpret the results of actual research projects

As food- and waterborne pathogens become increasingly resistant to antibiotics, researchers are turning to bacteriophages as an alternative to keep our food and water supplies safe. This timely book provides a unique comprehensive review of the literature on the application of bacteriophages as therapeutic and prophylactic agents in the food production and processing industries, including food animals, plants, and aquaculture.

Bacteriophages in the Control of Food- and Waterborne Pathogens begins with chapters that describe how bacteriophages function, explaining why they have the potential to be highly effective antimicrobials. Next, the book explores opportunities to use bacteriophages to detect bacterial contamination of foods and water as well as to control pathogens during both food production and processing. In addition, the book examines bacteriophages that can have a negative effect on industrial food processes and bacteriophages that potentially can lead to the evolution of foodborne pathogens. Finally, safety and regulatory issues, which are crucial to the success of bacteriophage use, are covered.

This book, the first to comprehensively address all aspects of the application of bacteriophages for food industry use, provides several tested and proven approaches to solving a very serious food safety issue. It is highly recommended reading for food microbiologists, food industry professionals, government regulators, and anyone interested in gaining a better understanding of how these fascinating microorganisms can help ensure a safe food supply.

Incorporating the latest findings from such disciplines as physiology, taxonomy, genomics, molecular biology and cell biology, this publication is an ideal starting point for any research study of filamentous fungi. Its extensive use of illustrations and tables also makes it an excellent textbook for both graduate and undergraduate students, helping them easily grasp and apply new concepts.

Cellular and Molecular Biology of Filamentous Fungi begins with an historical perspective, cell morphology and taxonomy, and then moves on to such topics as cell growth, development, metabolism, and pathogenesis. The book covers model organisms in detail as well as a broad variety of dimorphic and “obligate” filamentous fungal species. You’ll learn how individual species have adapted themselves to highly diverse ecological niches. In addition, comparisons to studies of the yeasts Saccharomyces cerevisiae and Schizosaccharomycespombe help you better understand the nature of fungi and the underlying evolution that leads to diversity in this fascinating kingdom.

Each chapter has been written by one or more leading experts. These authors, representing a “Who’s Who” in the field of fungal biology, offer you the latest genomic-based approaches alongside a careful evaluation of the current literature. Presenting the full range of the fungal kingdom and covering such important topics as saprophytes, pathogens and endophytes, this publication captures our current understanding of fungal biology, all in one volume.

Historic and culturally important objects, like all materials, are vulnerable to microbial attack. Over time, microorganisms can affect paint, wood, paper, glass, textiles, metal, wax, stone, polymers, and coatings. Microbial deterioration of heritage materials can be caused by the formation and growth of biofilms or by direct attack by a variety of microorganisms, all of which may be difficult to correct without also damaging the materials themselves. On the other hand, microbial processes can also be adapted to conserve and even restore heritage materials, pointing to the complex nature of microbial interactions with these irreplaceable materials.

Cultural Heritage Microbiology assembles over twenty scientific papers published during the past two decades, each presenting a major advance in some facet of this complex field. These seminal articles, by a wide range of international experts, are grouped by the historic material affected. Each section is introduced by a thorough review, written for this volume, which serves to introduce and synthesize these past studies and to combine them with the latest cutting-edge findings to present the most current state of the field. Extensive references in every chapter and article offer valuable resources for further investigation.

Cultural Heritage Microbiology is ideal for anyone concerned with recognizing and dealing with microbial deterioration of heritage materials. Professionals and students in microbiology, conservation science, archaeology, fine arts, architecture, museum conservation, and other fields will find here the most current knowledge and approaches to preserving cultural heritage objects for generations to come.

Key Features

Provides a unique, single overview of the seminal literature in conservation microbiology

Presents the current state of the art along with a synthesis of the major developments over the years

Represents the findings of leading international experts and pioneers in the field

Offers conservation scientists and conservators an inclusive view of the heritage conservation field plus extensive resources for further investigation

In recent years, researchers have discovered a new type of signaling mechanism based on cyclic di-GMP (c-di-GMP). This newly recognized second messenger is strongly associated with the transition between the motile and sessile states of many bacteria as well as the formation and dispersion of biofilms in many bacteria. The near universality of this second messenger in bacteria combined with the biomedical relevance and commercial importance of biofilms has generated much interest in c-di-GMP signaling research.

This book examines c-di-GMP signaling from a variety of angles, beginning with an introductory chapter that compares c-di-GMP to the better-known second messenger cAMP. Next, the book recounts the discovery of c-di-GMP, explains the important role of bioinformatics in the development and continued evolution of the field, and then describes the fundamental structure, function, regulation, and integration of c-di-GMP pathways. Further chapters explore the role of c-di-GMP in such diverse processes as flagellar biogenesis and motility, extracellular polysaccharide biosynthesis, biofilm development, virulence, and innate host immunity. The book ends with an expert forecast of the future of c-di-GMP signaling research and its applications.

Each chapter has been written and reviewed by leading pioneers in this rapidly evolving field. As the first book dedicated to c-di-GMP, it serves as a comprehensive reference on the state of the science for both experienced researchers and for those who are interested in discovering its many promising applications.

Picornaviruses afflict the animal kingdom with a wide range of maladies, notably the common cold, encephalitis, hepatitis, meningitis, and polio in humans and the economically devastating foot-and-mouth disease in animals. With contributions from leading experts from around the world, this volume examines the most current breakthroughs as well as the challenges that lie ahead in picornavirus research. Based on the most recent basic and clinical research findings, The Picornaviruses encapsulates our current knowledge of the molecular biology, evolution, and pathogenesis of this large family of viruses. In addition, it examines the diseases that these viruses cause and the latest vaccines and antiviral drugs to prevent and control those diseases.

The first eleven chapters explore the structural and mechanistic bases of picornavirus replication, highlighting new insights about the host cell interactions needed for virus growth. The next six chapters illustrate how the regular occurrence of mutations, typical of viruses with RNA as genetic material, generates the quasispecies dynamics that underlie viral fitness. Together with more drastic recombination events, the book shows how this error-prone RNA replication may have generated the variety of viruses embodied in the different picornavirus genera. The final twelve chapters focus on picornaviruses that cause disease, examining pathogenicity and innate and acquired immune responses against infection as well as the latest vaccine and antiviral drug strategies.

Synthesizing the latest developments in the study of picornaviruses, the book underscores our growing understanding of the close connections among picornavirus biology, diversity, evolution, and disease. Moreover, it serves as a springboard for developing new approaches to understanding this important family of viruses as well as preventing and treating picornaviral diseases.

Since 1995, the program committees of the Interscience Conference on Antimicrobial Agents and Chemotherapy and the Infectious Diseases Society of America have organized sessions on current and emerging infectious disease threats during their annual meetings. These sessions explore strategies for the prevention and control of bacteria, viruses, fungi, and parasites that can harm public health. Chapters in Emerging Infections 9 are based on recent sessions, focusing on a broad range of infectious agents that pose challenges for the clinical, laboratory, research, public health, and animal health communities.

Emerging Infections 9 reflects the diversity of infectious agent threats in the 21st century. Some of these agents have been only recently discovered, such as the Acanthamoebapolyphagamimivirus. Others are known pathogens presenting new challenges, such as human adenovirus 14. Some infectious agents discussed in the book are currently regional threats, whereas others affect populations around the world. However, every regional threat is potentially a global threat, an issue explored in detail in this edition. Moreover, the bookï¿½s discussion of the One Worldï¿½One Health Initiative underscores the need for a global, multidisciplinary approach in investigating, developing, and implementing solutions.

Each chapter has been contributed by one or more leading experts in infectious diseases, offering perspectives from basic and clinical research, epidemiology, and public health. Despite progress in the prevention and control of infectious diseases during the past several decades, many challenges remain at the same time as new challenges emerge. Emerging Infection 9ï¿½s coverage of current and emerging threats is therefore essential for anyone involved in the fight against infectious diseases, including professionals in microbiology, epidemiology, public health, and clinical and veterinary medicine.