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How many cpu 's do you have on your machine.set the db_block_lru_latches to approximately twice the number of cpus if your instance is hevaily loaded.say for example if u have 10 cpus i suggest that you first start out with something like 5 then check for latch contenation with V$LATCH,V$SESSION_EVENT
Note however if you have a single cpu machine you wont greatly benifit by setting this paarmeter.