The hexosamine biosynthetic pathway has been hypothesized to be involved in mediating some of the toxic effects of hyperglycemia. Glutamine:fructose-6-phosphate amidotransferase (GFA), the first and… (More)

The biosynthetic pathway for hexosamine mediates some of the adverse effects of high glucose. The rate limiting enzyme in this pathway is glutamine:fructose-6-phosphate amidotransferase (GFA). Using… (More)

BACKGROUND
The hexosamine biosynthesis pathway acts as a cellular glucose sensor and mediates many of the adverse effects of glucose. Increased flux through this pathway results in insulin resistance… (More)

Hyperglycemia is responsible for many of the vascular complications and metabolic derangements seen in diabetes. One potential regulator of the effects of glucose is the hexosamine biosynthesis… (More)