Development of sciences and technology is growing especially in
pharmaceuticals has resulted in significant changes in the
technology of pharmaceutical preparations such as drugs. The
absorption process of drugs with low solubility determined by
dissolution step rate limiting step. To improve the dissolution
rate can be done by means of the formation of inclusion
complexes 946-cyclodextrin drug with Supercritical Fluid SCF.
One way to improve the complexation of an inclusion complex of
946 - cyclodextrin in the drug can be made by adding water to the
mixture of 946 - cyclodextrin - drug . The purpose of this study was
to obtain inclusion complexes of ketoprofen - 946 - cyclodextrin
using supercritical fluid technology to study the effect of
different saturation pressure vessel and the addition of water to
the inclusion complex of ketoprofen - 946 - cyclodextrin. This study
begins with a mixture of ketoprofen 946-cyclodextrin ratio 15
ww and added water by manually blended using mortar for
about 10 minutes. Then be saturated at 50 oC with variations of
the pressure of supercritical carbon dioxide for about 2 hours and
mixed continuously then soon be dried.. Characterization of
inclusion complexes performed with analysis Differential
scanning calorimetry DSC Scanning Electron Microscopy
SEM Drug Release and Drug Loading . From this study can be
concluded ketoprofen inclusion complex 946 - Cyclodextrin can be produced using supercritical carbon dioxide by complexation
between 82.9 to 100 . Drug loading analysis of complex
inclusion at 80 bar pressure tends qualified Farmakope
Indonesias with a range of 87.29 to 104.52 . Drug loading
analysis on the addition of 40 water tends qualified Farmakope
Indonesias with a range of 76.92 to 100.34 . Drug release
analysis of complex inclusion at pressure 80 120 bar and the
addition of 60 80 water have a faster dissolution rate
compared to pure ketoprofen.

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