The Bohemian culture, with Prague as a centre, has over centuries turned out to be exorbitant aesthetically fruitful surroundings, combining excellent craftsmanship, science and art innovatively in this area, in spite of the dominating historical position of being suppressed. This article opens a row of examples of potentials in Czech design and performance, addressing following core elements in the analysis of the “Genius Loci” – the essence and contributing power – of Prague: 1) The materiality, the geography, the landscape 2) The complex and outstanding Bohemian History 3) The pedagogical embryology 4) The unique mentality of the Czech population 5) Combined multidimensional innovative aesthetics