More Drugs That Interfere With Ciprofloxacin

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Iron can bind to ciprofloxacin in the digestive tract, reducing the amount that is absorbed into the bloodstream. You should take your ciprofloxacin dose at least two hours before or six hours after taking any iron supplements to help minimize this drug interaction.

QT-Prolonging Medications

In general, ciprofloxacin should be used with caution when combined with any other medications that can cause QT prolongation (a certain change in the heart rhythm). Combining these medications may increase the risk of a life-threatening arrhythmia. Talk to your healthcare provider about this interaction if you take any QT-prolonging drugs.

Methotrexate

Ciprofloxacin may increase the amount of methotrexate in your blood, increasing your risk for potentially serious side effects. If you take these medications together, your healthcare provider may need to monitor you closely for methotrexate toxicity.

Mycophenolate

Ciprofloxacin may decrease the amount of mycophenolate in your blood, potentially decreasing its effectiveness. If you take these medications together, your healthcare provider may need to monitor you more closely to make sure mycophenolate is working for you.

NSAIDs

In clinical trials, there were reports of seizures occurring when NSAIDs where given in combination with high doses of ciprofloxacin. Check with your healthcare provider before taking these drugs together.

P-glycoprotein Inducers

P-glycoprotein (Pgp) is a protein found in the body. One of its roles is to help remove substances such as medications from the body. Ciprofloxacin is one of the medications partly removed from the body by Pgp. Medications known as Pgp inducers increase the action of Pgp. Thus, taking ciprofloxacin with a Pgp inducer may decrease the amount of ciprofloxacin in your blood, potentially making it less effective.

Your healthcare provider may need to monitor you more closely if you take ciprofloxacin with a Pgp inducer to make sure your infection is completely treated.

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