In the fragments area, Susan Boyd has co-authored several reviews, including “Fragment-Based Drug Discovery and Protein-Protein Interactions ” (Research & Reports in Biochemistry, 14(4), 13-26, (2014)) which also includes some research on the properties of fragments identified as active against PPI targets and was featured in the Practical Fragments Blog, “Fragment library design considerations”, WIREs Computational Molecular Science, 2, 868-885 (2012), and “Targeting cancer using fragment based drug discovery”, Anti-Cancer Agents in Medicinal Chemistry, 12(1), 40-48 (2012). In 2010 Susan Boyd also published a paper in Drug Discovery Today with Gerdien de Kloe on “Fragment Library Design: Efficiently hunting drugs in chemical space”, DOI doi:10.1016/j.ddtec.2010.11.010, journal reference – Drug Discovery Today: Technologies, Volume 7, Issue 3, Autumn 2010, Pages e173-e180. The paper describes common sources of fragment libraries, some commercially available fragment sets and some useful considerations when designing or purchasing sets of fragments.

In October 2010 a paper co-authored by Susan Boyd of CompChem SolutionsTM entitled “Scoring of senescence signalling in multiple human tumour gene expression datasets, identification of a correlation between senescence score and drug toxicity in the NCI60 panel and a pro-inflammatory signature correlating with survival advantage in peritoneal mesothelioma” was published in BMC Genomics, (W Nicol Keith et al, BMC Genomics, vol 11, 532, 2010) in collaboration with scientists from Cancer Research Technology, the Beatson Institute and the IRCCS Istituto Nazionale dei Tumori in Italy.

In May 2008 a paper entitled “Molecular Characterisation of Macbecin as an Hsp90 Inhibitor”, co-authored by Susan Boyd of CompChem SolutionsTM in collaboration with a team from Biotica Ltd was published in the Journal of Medicinal Chemistry (Martin et al, J Med Chem, vol 51, 2853-2857, 2008). This is the second paper in the Hsp90 inhibitor series.

CompChem SolutionsTM presented a poster on how computational chemistry can accelerate drug discovery, at the Genesis V Conference (London Biotech Network) in December 2005. The poster described the use of Inte:Ligand’s LigandScout software for extraction of protein structure-based pharmacophores for CDK2, with subsequent virtual screening approaches, as well as a description of various library design techniques to aid selection of synthetic candidates. Copies of the poster can be obtained by contacting CompChem SolutionsTM.