Re: Thinking about suicide - To SLS

Another possibility is that the second messenger system of affected neurons is "primed" to effect quickly the transcription of those proteins that lead to resistence to a particular drug. Whatever the mechanism, many people do experience antidepressant-induced antidepressant refractoriness.

I am having a hard time believing that there is absolutely no treatment that will work for you. I commend you for not giving up after so many years. I believe that you will survive long enough to find a treatment that gives you back what you once had. Never give up.

I am hoping that the addition of lithium is the final key that brings me to remission. I am currently taking 5 drugs, each of which has been optimized through experimentation. For you, I think another good sign is that Zyprexa helps. You are not completely areactive to treatment.