Arg-216 and Arg-237 play crucial roles in the substrate specificity of DDO.

reports that the behavioral phenotype of the Dco (show CSNK1E ELISA Kits)-/- mouse is characterized by deficits in prepulse inhibition of the acoustic startle reflex and in motor coordination on the RotoRod

Human D-Aspartate Oxidase (DDO) interaction partners

This study is the first to report robust age associations for DNA methylation in MYOF (show MYOF ELISA Kits) and DDO, both of which have plausible functional roles in aging

SNPSs R216Q and S308N reduce enzyme activity towards acidic d-amino acids, decrease the binding affinity for the coenzyme flavin adenine dinucleotide and decrease the temperature stability. Expression of DDO genes carrying the R216Q or S308N SNP substitutions may increase the d-aspartate content in humans and alter homeostasis of several other amino acids.

Characterization of the enzymatic and structural properties of human D-aspartate oxidase and comparison with those of the rat and mouse enzymes

There is a significant increase in DDO mRNA expression in the prefrontal cortex of patients with schizophrenia compared to controls.

data do not suggest that DDO plays a role in the etiology of schizophrenia in the German population

DDO plays important roles to prevent undesirable off-target action of D-aspartate by strictly controlling local D-aspartate concentration in the pituitary and pineal glands

kinetic properties of DDO suggested that at high substrate concentrations, the FAD (show PSEN1 ELISA Kits)-reduced form of the enzyme also catalyzes the reaction: the oxidative half-reaction precedes the reductive one.

D-Aspartate Oxidase (DDO) Antigen Profile

Antigen Summary

The protein encoded by this gene is a peroxisomal flavoprotein that catalyzes the oxidative deamination of D-aspartate and N-methyl D-aspartate. Flavin adenine dinucleotide or 6-hydroxyflavin adenine dinucleotide can serve as the cofactor in this reaction. Two transcript variants encoding different isoforms have been found for this gene.