CD Projekt revealed that The Witcher 2 will utilize SecuROM copy-protection for its retail release, deciding it was the least intrusive way to protect its content from piracy. Though they are aware some gamers will groan at the decision to use SecuROM, CD Projekt noted that the game will allow for "unlimited installations on an unlimited number of computers" and allow "play on up to five computers at once." The game requires an internet connection for the game's initial activation. According to the presentation, this will ensure that The Witcher 2 cannot be played before the game's May 17 release.

The Witcher 2 will also be available on digital distribution platforms, including DRM-free on Good Old Games (GOG.com).

Although the game will include a serial code for activation, users that purchase the game on GOG.com will not require the code to play the game. The GOG.com release will come completely unlocked; however, a code will be included for users that wish to download future DLC--which requires the serial key to access the content.

Beginning May 10, users that have pre-purchased The Witcher 2 on GOG.com will have the ability to pre-load 90% of the final game. Good Old Games will be the only digital distribution platform that will feature a pre-load for the game.

Unlike the original game in the series, The Witcher 2 will not see any censorship between regions. Each region will feature the same story and gameplay. Additionally, the sequel features up to sixteen different endings. During the conference, CD Projekt issued a challenge to players of The Witcher 2: the first person to unlock all sixteen endings (and prove it with a save file), will be awarded a special t-shirt.

CD Projekt recently announced the PC specs for the upcoming, anticipated sequel.