A gang of anti-Semitic thugs roughed up a Jewish man and his wife on the Upper East Side on Monday evening before fleeing in cars flying Palestinian flags, police sources told The Post.

Two cars and multiple motorcycles pulled up to the couple on East 63rd Street near Third Avenue just after 8 p.m., and the as sailants began yelling “anti-Jewish statements,” the sources said.

One of the goons threw a water bottle that hit the wife, and the 27-year-old husband was punched in the side of his head when he came to her defense, according to law enforcement sources.

Police sources said the creeps then raced back to their waiting vehicles, some of which bore Palestinian flags, and took off.

Police have suggested that the couple were targeted because the man was wearing a Yarmulke identifying him as Jewish. Current reports give a description of the vehicles that the suspects were driving.

Police sources said they are looking for a 2005 Cadillac Escalade with NY State plates and a Nisan Altima with Florida plates. It’s possible that the police have the plate numbers of both vehicles, sources added.