Schumaker singled off Mujica leading off the ninth. Shortstop Zack Cozart fell behind 0-2 after two sacrifice bunt attempts then lined a single to left. Second baseman Ramon Santiago struck out trying to bunt. And, Mujica retired the final two batters for his third save for Boston (54-65).

Ranaudo (2-0) was making his second major league start and first against a National League opponent. He allowed four earned runs on eight hits including two homers in six innings.

Reds starter Mike Leake (9-11) allowed five earned runs and eight hits in five innings. He also hit a solo home run. Leake walked one and struck out five.

The Red Sox pounced on Leake in the first inning. Second baseman Brock Holt led off with a walk, advanced to second on a wild pitch and scored on right fielder Daniel Nava's RBI hit.

Nava later slid home on a Napoli's grounder to make the score 2-0.

Schumaker, a late replacement in right field for Jay Bruce who was scratched due to illness, tied the score 2-2 with a 411-foot solo shot in the fourth.

Two batters later, Leake hit his fourth career home run to put Cincinnati ahead 3-2.

But the Red Sox responded quickly in the fifth with an RBI single by left fielder Yoenis Cespedes and a two-run home run by Napoli, putting them ahead 5-3.

Second baseman Kristopher Negron tripled and scored on third baseman Todd Frazier's sacrifice fly to trim the Reds' deficit to 5-4.

NOTES: Boston LF Yoenis Cespedes left the game after six innings with a right hand contusion. … Red Sox CF Jackie Bradley Jr.'s second-inning single snapped an 0-for-35 skid. … Reds 2B Brandon Phillips could begin a minor-league rehab assignment as early as Friday. Phillips, who's been on the disabled list since suffering a torn ligament in his left thumb making a diving stop on July 9, began taking batting practice this week. … Red Sox 2B Dustin Pedroia was given a day off on Wednesday. "He understands," said Red Sox manager John Farrell. "I think that 19-inning game (on Saturday) took a lot out of the position players … plus day game after a night game. I think it's a good day for a break." … Reds RF Jay Bruce was scratched from Wednesday's starting lineup due to illness. Skip Schumaker replaced Bruce in right field.