Allows gene fusion discovery using RNA-Seq data. Defuse’s aim is to guide a dynamic programming-based split read analysis with discordant paired end alignments. The software employs heuristic filters to reduce the number of false positives and produces a fully annotated output for each predicted fusion. It was applied to ovarian tumours and sarcomas from the OvCaRe (Ovarian Cancer Research) frozen tumor bank.

Type:

Desktop

deFuse specifications

Unique identifier:

OMICS_01345

Interface:

Command line interface

Input format:

FASTQ

Operating system:

Unix/Linux

Computer skills:

Advanced

Maintained:

Yes

Software type:

Package/Module

Restrictions to use:

None

Output format:

TSV

Programming languages:

C++

Stability:

Stable

versioning

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Funding source(s)

Supported by grants from the British Columbia Cancer Foundation and the Vancouver General Hospital Foundation, Genome Canada, the Michael Smith Foundation for Health Research, the Canadian Breast Cancer Foundation and the Canadian Institutes of Health Research’s Bioinformatics Training Program.