A chemically inactivated, adjuvanted product for use in healthy pregnant swine as an aid in the prevention of colibacillosis (caused by E. coli antigens K88, K99, F41, 987P), atrophic rhinitis and pneumonia (caused by B. bronchiseptica and P. multocida non-toxigenic type A and toxigenic types A and D) in their nursing piglets. This product is also used for the prevention of erysipelas in healthy pregnant swine caused by E. rhusiopathiae.