When I hear comics tell those jokes, I wonder what other, more personal experiences they might have to talk about.. You say you worry that people think you look like a lesbian and you aren’t one? Okay, sure. How large a part of your life is that fear? The audience you are in front of tonight might never see you again, so is it a crucial enough aspect of your life that you’d want to it be the only topic an audience ever hears you discuss? If not, talk about something that is. If so, why is that? What are you so afraid of?

I think that's an interesting frame: If an audience is only going to see you once and hear you talk about one thing, what would you want it to be?