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About the Book

In recent years, considerable advances have been made in our knowledge and understanding of Parkinson's disease (PD). In particular, there has been an explosion of information regarding genetic contributions to the etiology of PD and an increased awareness of the importance of the non-motor features of the disease. Theories regarding the pathogenesis and pathophysiology of PD have also been refined, and new treatment modalities and advances implemented. Reflecting these changes, this second edition features new chapters devoted to genetic aspects of PD, non-motor features of the disease, and aspects of the pathophysiology, pathogenesis, and treatment of PD.

Reviews

Praise for the First Edition:

"…an invaluable reference outlining our current understanding of this disease. … contains all the information that any student new to the field requires to develop a thorough understanding of PD. With chapters about everything from epidemiology, to theories of pathogenesis, and back to symptoms and treatment, this book covers the entire range of what we can know about a biological phenomenon, from the molecular, cellular and genetic levels, through to the whole human being and the entire human population. … accessible to both seasoned veterans of Parkinson’s research, looking for the last information in an area outside their direct expertise, and novices, trying to grasp an understanding of the extent of our current knowledge of PD."

"I would recommend it highly to those with a specialist’s interest in Parkinson’s disease and to more general neurologists who want an accessible, readable guide to diagnosing and treating this disease."

—New England Journal of Medicine

"… tightly constructed and well organized. It stands out as the most comprehensive volume available on this disorder."

—JAMA

"A new encyclopedic collection of clinical wisdom … the largest and most comprehensive of several reference books that focus on this illness … masterfully organized."

—Parkinson’s Disease Update

Table of Contents

Overview

James Parkinson

Jennifer G. Goldman and Christopher G. Goetz

Parkinson’s Disease: Where Have We Been?

Lawrence W. Elmer

Parkinson’s Disease: Where Are We?

Raúl de la Fuente-Fernández

Epidemiology

Epidemiology of Parkinson’s Disease: An Overview

Monica Korell and Caroline M. Tanner

Environmental Toxins and Parkinson’s Disease

Jason R. Cannon and Timothy J. Greenamyre

Rural Environment and Parkinson’s Disease

Daniel Strickland

Industrial and Occupational Exposures and Parkinson Disease

Samuel Goldman

Tetrahydroisoquinolines and Parkinson’s Disease

Mark S. LeDoux

Endogenous Neurotoxins in the Pathogenesis and Progression of Parkinson’s Disease