Pyruvate (the buffered form of pyruvic acid) is a product created in
the body during the metabolism of carbohydrates and protein. This
supplement has been used in connection with the following health
conditions:

Obesity - 6 to 10 grams daily combined with an exercise program
Combining exercise with pyruvate may help speed up your metabolism.

Athletic Performance - 100 grams of a combination of dihydroxyacetone and pyruvate
One group of researchers has reported that a combination of
dihydroxyacetone and pyruvate enhanced the endurance of certain
muscles.

Athletic Performance and Improving Body Composition with
Strength Training in Untrained People - Refer to label instructions for
dosage
Three controlled studies of people using a
combination of pyruvate and an exercise program reported positive
effects on weight loss and body fat

How to Use ItMost human research with pyruvate and weight loss has used at
least 30 grams per day. However, such large amounts may not be
necessary. In a six-week double-blind trial, as little as 6 grams per
day of pyruvate in combination with exercise led to greater weight loss
and loss of body fat, compared with a placebo plus exercise. Because it
is not an essential nutrient, pyruvate is not associated with a
deficiency.

Where to Find ItPyruvate is formed in the body as a byproduct of the normal
metabolism of carbohydrates and protein and is present in several
foods, including red apples, cheese, dark beer, and red wine. Dietary
supplements of pyruvate are also available.

Side Effects & InteractionsHigh intakes of pyruvate can trigger gastrointestinal upset,
such as gas, bloating, and diarrhea. One preliminary study in
exercising women found 10 grams per day of pyruvate reduced blood
levels of HDL (the “good” cholesterol) after one month.

At the time of writing, there were no well-known interactions with this supplement.