In Ancient Greek, 'Χ' and 'Ψ' were among several variants of the same letter, used originally for /kʰ/ and later, in western areas such as Arcadia, as a simplification of the digraph 'ΧΣ' for /ks/. In the end, more conservative eastern forms became the standard of Classical Greek, and thus 'Χ' (Chi) stood for /kʰ/ (later /x/; palatalized to [ç] in Modern Greek before front vowels). However, the Etruscans had taken over 'Χ' from western Greek, and it therefore stands for /ks/ in Etruscan and Latin.

The letter 'Χ' ~ 'Ψ' for /kʰ/ was a Greek addition to the alphabet, placed after the Semitic letters along with phi 'Φ' for /pʰ/.

In English orthography, ⟨x⟩ is typically pronounced as the voiceless consonant cluster/ks/ when it follows the stressed vowel (e.g. ox), and the voiced consonant /ɡz/ when it precedes the stressed vowel (e.g. exam). It is also pronounced /ɡz/ when it precedes a silent ⟨h⟩ and a stressed vowel (e.g. exhaust).[2] Before ⟨i⟩ or ⟨u⟩, it can be pronounced /kʃ/ or /ɡʒ/ (e.g. sexual and luxury); these result from earlier /ksj/ and /ɡzj/. It also makes the sound /kʃ/ in words ending in -xion (typically used only in British-based spellings of the language; American spellings tend to use -ction). When ⟨x⟩ ends a word, it is always /ks/ (e.g. fax), except in loan words such as faux (see French, below).

There are very few English words that start with ⟨x⟩ (the fewest number of any letter). When ⟨x⟩ does start a word, it is usually pronounced /z/ (e.g. xylophone, xenophobia, and xanthan); in rare recent loanwords or foreign proper names, it can also be pronounced /s/ (e.g. the obsolete Vietnamese monetary unit xu) or /ʃ/ (e.g. Chinese names starting with Xi like Xiaomi or Xinjiang). Many of the words that start with ⟨x⟩ are of Greek origin, or standardized trademarks (Xerox) or acronyms (XC). In abbreviations, it can represent "trans-" (e.g. XMIT for transmit, XFER for transfer), "cross-" (e.g. X-ing for crossing, XREF for cross-reference), "Christ-" as shorthand for the labarum (e.g. Xmas for Christmas, Xian for Christian), the "crys-" in crystal (XTAL), or various words starting with "ex-" (e.g. XL for extra large, XOR for exclusive-or).

In Norwegian, ⟨x⟩ is generally pronounced [ks], but since the 19th century, there has been a tendency to spell it out as ⟨ks⟩; it may still be retained in personal names, though it is fairly rare, and occurs mostly in foreign words and SMS language. Usage in Danish and Finnish is similar (while Swedish, on the other hand, makes frequent use of ⟨x⟩ in native words as well as in loanwords).

In German, generally pronounced [ks]; in native words, however,such as Ochs or wachsen, the cluster [ks] is often written ⟨chs⟩.

French: at the ends of words, silent (or [z] in liaison if the next word starts with a vowel). Three exceptions are pronounced [s]: six ("six"), dix ("ten") and in some city names such as Bruxelles (although some people pronounce it 'ks') or Auxerre; it is fully pronounced [ks] in Aix, Aix-les-Bains, Aix-la-Chapelle. It is pronounced [z] in sixième and dixième. Otherwise [ks] or (primarily in words beginning with ex- followed by a vowel) [ɡz].

In Italian, ⟨x⟩ is either pronounced [ks], as in extra, uxorio, xilofono,[4] or [ɡz], as exogamia, when it is preceded by ⟨e⟩ and followed by a vowel. In several related languages, notably Venetian, it represents the voiced sibilant [z]. It is also used, mainly amongst the young people, as a short written form for "per", meaning "for": for example, "x sempre" ("forever"). This is because in Italian the multiplication sign (similar to ⟨x⟩) is called "per". However, ⟨x⟩ is found only in loanwords, as it is not part of the standard Italian alphabet; in most words with ⟨x⟩, this letter may be replaced with 's' or 'ss' (with different pronunciation: xilofono/silofono, taxi/tassì) or, rarely, by 'cs' (with the same pronunciation: claxon/clacson).

In Old Spanish, ⟨x⟩ was pronounced [ʃ], as it is still currently in other Iberian Romance languages. Later, the sound evolved to a hard [x] sound. In modern Spanish, due to a spelling reform, whenever ⟨x⟩ is used for the [x] sound it has been replaced with ⟨j⟩, including in words that originally had ⟨x⟩ such as ejemplo or ejercicio, though ⟨x⟩ is still retained for some names (notably 'México', even though 'Méjico' may sometimes be used in Spain). Presently, ⟨x⟩ represents the sound [s] (word-initially), or the consonant cluster [ks] (e.g. oxígeno, examen). Rarely, it can be pronounced [ʃ] as in Old Spanish in some proper nouns such as 'Raxel' (a variant of Rachel) and Uxmal.

In Galician and Leonese, ⟨x⟩ is pronounced [ʃ] in most cases. In learned words, such as 'taxativo' (taxing), it is pronounced [ks]. However, Galician speakers tend to pronounce it [s], especially when it appears before plosives, such as in 'externo' (external).

In Catalan, ⟨x⟩ has three sounds; the most common is [ʃ]; as in 'xarop' (syrup). Other sounds are: [ks]; 'fixar' (to fix), [ɡz]; 'examen'. In addition, [ʃ] gets voiced to [ʒ] before voiced consonants; 'caixmir'. Catalan also has the digraph ⟨tx⟩, pronounced [tʃ].

In Portuguese, ⟨x⟩ has four main sounds; the most common is [ʃ], as in 'xícara' (cup). The other sounds are: [ks] as in 'flexão' (flexion); [s], when preceded by E and followed by a consonant, as in 'contexto' ([ʃ] in European Portuguese), and in a small number of other words, such as 'próximo' (close/next); and (the rarest) [z], which occurs in the prefix 'ex-' before a vowel, as in 'exagerado' (exaggerated). A rare fifth sound is [ɡz], coexisting with [z] and [ks] as acceptable pronunciations in exantema and in words with the Greek prefix 'hexa-'.

In Venetian, it represents the voiced alveolar sibilant [z] much like in Portuguese 'exagerado', English 'xylophone' or in the French 'sixième'. Examples from medieval texts include raxon (reason), prexon (prison), dexerto (desert), chaxa/caxa (home). Nowadays, the best-known word is xe (is/are). The most notable exception to this rule is the name Venexia[veˈnɛsja] in which ⟨x⟩ has evolved from the initial voiced sibilant [z] to the present day voiceless sibilant.

In Maltese, ⟨x⟩ is pronounced [ʃ] or, in some cases, [ʒ] (only in loanwords such as 'televixin', and not for all speakers).

In Polish, ⟨x⟩ was used prior to 19th century both in loanwords and native words and was pronounced [ks] or [ɡz], e.g. xiążę, xięstwo (now książę, księstwo). Later was replaced by ⟨ks⟩ and ⟨gz⟩ in all words and remained only in surnames as Axentowicz, Jaxa, Koxowski, Mixtacki, Rexemowski, Xiężopolski, names as Xawery, Xymena and abbreviations.

Additionally, in languages for which the Latin alphabet has been adapted only recently, ⟨x⟩ has been used for various sounds, in some cases inspired by European usage, but in others, for consonants uncommon in Europe. For these no Latin letter stands out as an obvious choice, and since most of the various European pronunciations of ⟨x⟩ can be written by other means, the letter becomes available for more unusual sounds.

In transliteration of Indian languages, ⟨x⟩ represents the consonant cluster [kʃ] in alternate spellings of words containing 'क्ष' (kṣ), especially names such as Laxmi and Dixit. Less frequently, ⟨x⟩ is used to represent 'ख़' [x].

It may also be used as a typographic approximation for the multiplication sign. In mathematical typesetting, x meaning an algebraic variable is normally in italic type (x{\displaystyle x\!}), partly to avoid confusion with the multiplication symbol. In fonts containing both x (the letter) and × (the multiplication sign), the two glyphs are dissimilar.

It can be used as an abbreviation for 'between' in the context of historical dating; e.g., '1483 x 1485'.

Maps and other images sometimes use an X to label a specific location, leading to the expression "X marks the spot".[6]

In art or fashion, the use of X indicates a collaboration by two or more artists, e.g. Aaron Koblin x Takashi Kawashima. This application, which originated in Japan, now extends to other kinds of collaboration outside the art world.[9] This usage mimics the use of a similar mark in denoting botanical hybrids, for which scientifically the multiplication sign (×) is used, but informally a lowercase "x" is also used.

^King, David A. (2001). The Ciphers of the Monks. p. 282. In the course of time, I, V and X became identical with three letters of the alphabet; originally, however, they bore no relation to these letters.