Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Ebuxo 40mg Tablet may be taken with or without food, but it is better to take it at a fixed time.

Animal studies have shown adverse effects on the foetus, however, there are limited human studies. The benefits from use in pregnant women may be acceptable despite the risk. Please consult your doctor.

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Lactation

CAUTION

Ebuxo 40mg Tablet is probably unsafe to use during lactation

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Limited human data suggest that the drug could represent a significant risk to the baby.

Rosuvastatin can be taken with Ebuxo. Rosuvastatin is used to lower bad cholesterol and Ebuxo is used to lower uric acid levels in patients with gout. Many patients of high cholesterol levels also have high uric acid levels. There are no human studies available on this interaction. However, animal research shows that when given together, Ebuxo can increase the blood levels of Rosuvastatin causing a higher risk of its side effects like muscle pain and muscle damage. So, a dose adjustment of Rosuvastatin may be needed when given along with Ebuxo.

Gout is a type of arthritis in which uric acid levels are very high in the blood and they get deposited in the joints causing swelling, redness and sudden pain in these joints. Ebuxo works by inhibiting the enzyme xanthine oxidase involved in the synthesis of uric acid and hence decreases the level of uric acid in the blood.

After oral intake, the peak plasma concentration of Ebuxo is achieved between 1 to 1.5 hours. However, it may take a few days to weeks to show its effect and you can experience gout attacks during this time. Continue to take your medicine during this time as with continuous use these attacks would decrease.

Ebuxo is not indicated for the treatment of heart failure. However, high uric acid levels is a risk factor for cardiovascular diseases and the benefit of urate-lowering therapy for cardiac diseases is being explored.

Ebuxo is not indicated for the treatment of chronic kidney disease. However, it can be safely used in patients with mild to moderate renal failure for lowering uric acid levels. Safety of the drug in severe renal failure is not established.

Ebuxo is not used for the treatment of cancer. However, patients with malignant cancer when given anti-cancer drugs, experience a serious condition known as tumor lysis syndrome characterized by increased potassium, phosphate and uric acid levels in the blood due to the killing of cancer cells and this can lead to acute kidney injury, cardiac arrhythmia, and seizures. Ebuxo helps in this condition by lowering the uric acid levels and preventing further complications.

Q. Can I take Ebuxo with allopurinol?

Both Ebuxo and allopurinol are uric acid lowering agents and work in a similar way. So, using both the two medicines together may not be very beneficial and can increase the risk of side effects. However, there have been studies where Ebuxo when used with allopurinol in patients with refractory gout, was quite effective in providing relief. So, a combined use would be best decided by your treating doctor depending on your condition.

Ebuxo is not indicated in the treatment of kidney stones. However, some studies show that high renal uric acid excretion may precipitate the formation of calcium stones in the kidney and hence, suggest Ebuxo may have a role in the reduction of stone formation.

Q. Can I take Ebuxo with colchicine?

Ebuxo can be taken with colchicine. In the initial few days of starting Ebuxo, patients may experience an increase in gout attacks because of the movement of uric acid and colchicine and painkillers are given to these patients for the relief of pain and inflammation.

Q. Can I take Ebuxo with azathioprine?

Ebuxo should not be taken with azathioprine. Taking both the medicines together will increase the levels of azathioprine and can cause toxicity.

Ebuxo can generally be taken safely together with antibiotics. However, interactions can occur. Talk to your doctor about the right antibiotic therapy for your condition while you are also taking Ebuxo.

“The following are the results of on-going survey on 1mg.com for Ebuxo 40mg Tablet. These results only indicate the perceptions of the website users. Please base your medical decisions only on the advice of a doctor or a registered medical professional.”