Minocycline, 7-dimethylamini - 6 deoxy 6 - demethyltetracycline, &new semi-synthetic dervative of tetracycline was given in 50 cases of pyogenic infections of the skin of acute and chronic nature. The dosage of minocycline used was a loading dose of 200 mg in the morning and I 00 mg. the same evening, followed by I 00 mg twiccdaily for6 to I I days. In several cases, 100 mg of minocycline was later given once daily for periods varying from 2 to 23 days. The causative organism in most of the lesions was staphylococcus aureus. In 24 cases, these organisms were resistant to tetracycline and in 36 cases, to penicilun. None of the organisms were resistant to minocycline. Results were judged as excellent in 3 cases, good in 22, fair in 22 and poor in 3 cases. Minor side effects like giddiness were noted in 3 patients, nausea and vomiting occurred in another patient despite these side effects the patients continued the course of minocycline.