Educated in Constantinople. Worked as a lawyer. Convert to Christianity. Spritiual student of SaintSpyridon of Cyprus. Bishop of Leucosia (modern Nicosia), Cyprus. Supported Saint Athanasius of Alexandria in his opposition to Arianism; Saint Athanasius praised Tryphillius for his adherence to orthodox Christianity, so the Arians turned their attacks against him. He lived with no pomp or splendor, and preached every day. Saint Jerome considered him one of the most eloquent Church figures of his day, and he was particularly noted for his commentary on the Song of Songs.