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Citation and License

Arthritis Research & Therapy 2011, 13:128
doi:10.1186/ar3448

Published: 30 September 2011

Abstract

Synovitis and subchondral bone turnover are associated with pain in osteoarthritis.
Bisphosphonates provide tools for investigating these pathogenic mechanisms and also
may have therapeutic potential. Translating preclinical findings into new treatments
for human osteoarthritis requires a critical appraisal and refinement of animal models,
identification of those pathogenic mechanisms that are amenable to intervention, and
pharmacological targeting of those mechanisms in the right people at the right time.