Influence of distribution of small intestinal delivery of fat on satiety and energy intake in healthy volunteers.

- candidate number

4717

- NTR Number

NTR1584

- ISRCTN

ISRCTN wordt niet meer aangevraagd

- Date ISRCTN created

- date ISRCTN requested

- Date Registered NTR

11-dec-2008

- Secondary IDs

0710 MEC 08-1-008

- Public Title

Influence of distribution of small intestinal delivery of fat on satiety and energy intake in healthy volunteers.

- Scientific Title

Influence of distribution of small intestinal delivery of fat on satiety and energy intake in healthy volunteers.

- ACRONYM

N/A

- hypothesis

We hypothesise that increasing the luminal surface exposed to the emulsion will lead to a decrease in hunger and food intake, but that otherwise, the ileal infusion will have the greatest impact on these parameters.

Ready-to-drink (RTD) meal replacements are effective in reducing body weight in people following an overall diet plan. However, feelings of hunger return already within two hours after ingestion of these drinks, and this may influence compliance to the diet plan.
In order to optimize the satiating potency of triacylglycerols, we previously performed a study in which we varied the location of fat infusion, showing that activation of the ileal brake by ileal fat infusion reduced food intake by an additional 12 % compared to the same emulsion infused in the duodenum, thereby demonstrating the potency of the ileal brake to reduce food intake and satiety.
In rats, another method of increasing the satiating potency of a meal is by increasing the spread of fat emulsion over the small intestinal surface.
In the present study we will test the optimal distribution of an emulsion in the small intestine infusion, in order to maximize the effect on satiety parameters and food intake during an ad libitum-lunch. Furthermore, we aim to compare whether in humans increasing the surface area of infusion leads to an increase in inhibition of hunger and food intake.