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Topic: Zoloft plus wine (Read 372 times)

Just curiouser, how does Zoloft effect alchohal? I have been on a 12.5mg dose for about 7 days and this evening I had 2 large glasses of Merlot and feel really "messed up". I took a 1/2 of a .25 mg Xanax at about 7am, can't imagine that is affectingly now.....but not sure.

Antidepressants and alcohol consumption are usually not a very good mix. Normally a small dose of alcohol is OK on the weekends, however this is if you're stable on an antidepressant. Somaj, since you've just started, your body is still adjusting to the Zoloft (Setraline), so the side effects maybe coming from the antidepressant, the alcohol or both.

A previous poster over the summer raised the issue of regular alcohol consumption and being on Zoloft. By the way, I am using this older thread as a reference, and in no way making any negative comments about the OP, but referencing her experiences on antidepressant usage and drinking alcohol. Also note, in comparison to you, the OP had been on Zoloft much longer, but she never went over 50mg to manage her anxiety. The factor of a minimum therapeutic dose on Zoloft for over a year may also have an effect on the antidepressant effectiveness, just like taking Zoloft with regular alcohol consumption, however both the regular use of alcohol and dosage level, should be taken with serious consideration when being on an antidepressant.

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Just curiouser, how does Zoloft effect alchohal? I have been on a 12.5mg dose for about 7 days and this evening I had 2 large glasses of Merlot and feel really "messed up". I took a 1/2 of a .25 mg Xanax at about 7am, can't imagine that is affectingly now.....but not sure.

There are two things to consider. Firstly, antidepressants can make reactions to alcohol unpredictable. Sometimes a small amount will turn you your legs to rubber, on other occasions you could drink a herd of alcoholic elephants under the table without raising a sweat. So be very wary about driving, etc, until you get a handle on how alcohol is affecting you on the day.

Also keep in mind that alcohol and benzodiazepines are a bad combination. They are both CNS depressants which particularly affect the brain stem that, among other things, generates the breathing reflex. A couple of glasses of red wine and 0.125mg Xanax are unlikely to do any harm, but larger amounts of both could be problematic.

NOTE: I'm not a doctor, and particularly not yours, so there may be factors I'm unaware of. Therefore all advice is of a general nature and you should consult your doctor before following any of it, especially before changing med doses.