ABSTRACT
Cognitive impairment and Osteoporosis are two chronic degenerative diseases in which each of them and in
combination can cause significant functional impairment in the elderly. A few of studies have shown that low bone
mineraldensity(BMD)is associated with increased risk of cognitive impairment and Alzheimer and vise versa. In this
study, we aimed to measure the association between these two diseases in the elderly in Amirkola, Mazandaran
,north of Iran. This cross-sectional study, came from Amirkola Health an Aging Project (AHAP), the BMD was
measured by dual-energy X-ray absorptiometry using Lexxos densitometry of the left femoral neck and lumbar spine
(L2-4) and the results were expressed based on T-Score. Also, the MMSE standard questionnaire (Mini Mental State
Examination) was used to assess cognitive impairment.Data were analyzed using SPSS17statistical software, chisquare
test, t-test, Pearson correlation , and after adjusting for several confounding variables in multiple logistic
regression models we stimated odds ratio and compared cognitive impairment and normal cognitive statuse groups
with normal BMD and low BMD groups; P<0.005 was considered meaningful. In the total number of 1176 persons
with the average age of 68.43±7, 839 older people with normal cognitive status, hadBMDof the lumbar spine
(0.9±0.18gr/cm2) and 337 older adults had abnormal levels of cognitive status (0.79±0.18gr/cm2) (P = 0.000). For
femor results, (0.88±0.15gr/cm2)and(0.77±0.15gr/cm2)were obtained respectively (P= 0.000). Confounding factors
in osteoporosis and cognitive impairment were considered in findingsin which there was no difference in the results.
It seems that bone mineral density is associated with the cognitive status of older people, and this relationship holds
true for both sexes.Keywords: cognitive impairment, bone mineral density, osteoporosis
Ab. :BMD (Bone Mineral Density) MMSE(Mini Mental State Examination)