Current Medical MycologyCurrent Medical MycologyCurr Med MycolMedical Scienceshttp://cmm.mazums.ac.ir1admin2423-34392423-342010.29252/cmmenjalali139791gregorian201812144online1fulltextenBiomarker-guided antifungal stewardship policies for patients with invasive candidiasisAntifungal SusceptibilityAntifungal Susceptibility, مقاله مروری Reviews<div style="text-align: justify;">Invasive fungal infections (IFIs) are among the life-threatening issues in patients with impaired immune system. High administration of antifungals in these patients imposes a heavy economic burden on the national health system. In addition, despite the usually expensive antifungal regimens, the mortality rate due to fungal infections is still high, resulting in the loss of hundreds of lives per year.</div>
<div style="text-align: justify;">Survival rate is an indicator of the success of national healthcare policies. Early diagnosis of IFI is critical because any delays may be fatal. The weakness of the old-fashioned culture-based diagnostic methods lies in their time-consuming laboratory procedures. To overcome this problem, several diagnostic approaches have been developed to facilitate the early diagnosis of invasive candidiasis as the most prevalent IFI.</div>
<div style="text-align: justify;">These methods are based on the detection of serologic and molecular footprints. However, nowadays, antibiotic resistance and proper and cost-effective use of antibiotics are given special attention in national healthcare policies. The instructions for controlling these indices have been collected under the name of antibiotic stewardship. The present review study was targeted toward providing insight into novel diagnostic biomarkers and antifungal stewardship programs. The simultaneous investigation of these two issues facilitates the achievement of a novel health policy for the treatment of systemic candidiasis in immunocompromised patients.</div>
Keywords:&nbsp;Antifungal agents, Antimicrobial stewardship, Biomarkers, Candidiasis, Invasive fungal infections3744http://cmm.mazums.ac.ir/browse.php?a_code=A-10-289-1&slc_lang=en&sid=1Behnam Honarvar1003194753284600536410031947532846005364NoHealth Policy Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, IranKamran Bagheri Lankarani1003194753284600536510031947532846005365NoHealth Policy Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, Iranmehditaghavimehditaghavi90@gmail.com1003194753284600536610031947532846005366Yes
Mycology Research Center, Faculty of Veterinary Medicine, University of Tehran, Tehran, IranGhasem Vahedi1003194753284600536710031947532846005367NoMycology Research Center, Faculty of Veterinary Medicine, University of Tehran, Tehran, IranEsmaeil Mortaz1003194753284600536810031947532846005368NoDepartment of Immunology, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran