Although controversial, there is evidence that the most common type of
dominantly inherited HSP (due to SPG4/spastin gene mutation) also involves
disturbance in microtubulemediated axonal transport [9]. Spastin shares some
protein ...

Posted - June 2013 in Research Highlights
New findings about SPG3 and SPG4
Even in those with early-onset HSP, the probability of finding an SPG4 mutation is higher than an SPG3 mutation.
Differences in disease progression are associated with the age at onset.