The minimum system requirements call for a 2.0Ghz Intel Mac with at least 4.0GB RAM, a 512MB or better graphics card, and Mac OS 10.8.5 or later. The game supports the ATI 4850 series or better, Intel HD4000 series or better, and NVIDIA GT130, NVIDIA 9600 or NVIDIA 600 series or better.

The Director's Cut makes several improvements and additions to the original version of Deus Ex: Human Revolution. Boss fights have been overhauled, and improvements have been made to visuals and combat. It also comes with the Missing Link, Tong's Rescue Mission and Tactical Enhancement DLC packs, as well as developer commentary and a making-of documentary.