DRUG DESCRIPTION

VFEND® (voriconazole),
an azole antifungal agent is available as a lyophilized powder for solution for
intravenous infusion, film-coated tablets for oral administration, and as a
powder for oral suspension. The structural formula is:

Voriconazole is designated
chemically as (2R,3S)-2-(2, 4-difluorophenyl)-3-(5-fluoro-4-pyrimidinyl)-1-(1H-1,2,4triazol-1-yl)-2-butanol
with an empirical formula of C16H14F3N5O
and a molecular weight of 349.3.

VFEND I.V. is intended for
administration by intravenous infusion. It is a single-dose, unpreserved
product. Vials containing 200 mg lyophilized voriconazole are intended for
reconstitution with Water for Injection to produce a solution containing 10
mg/mL VFEND and 160 mg/mL of sulfobutyl ether beta-cyclodextrin sodium. The
resultant solution is further diluted prior to administration as an intravenous
infusion [see DOSAGE AND ADMINISTRATION].

What are the precautions when taking voriconazole (Vfend)?

Before taking voriconazole, tell your doctor or pharmacist if you are allergic to it; or to other azole antifungals (e.g., itraconazole, ketoconazole); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.