The use of inhibitors to components of cancer signaling pathways is dogged by resistance and cross-talk upregulating compensatory pathways. A new computational framework characterizes the cross-talks between pathways in breast cancer cell lines.

A highly curated metabolic network model of the bacterium Clostridium difficile, which can cause serious hospital infections, predicts a number of essential genes presenting potential drug targets, some of which have homologs with existing inhibitory drugs.

An updated model of metabolism and protein expression in E. coli incorporates the role of four sub-cellular compartments, along with a reconstruction of protein translocation pathways, demonstrates the value of including compartmentalization in models to generate new biological insights

A new algorithm to calculate elementary flux modes in genome-scale, gives similar speed to existing Double Description approaches but is scalable, and can incorporate additional flux constraints to generate a full subset of EFMs of interest.

A new generic framework for combined model parameterisation, comparison of model alternatives and analysis of model mechanisms and was effective in reparameterising an existing model of cardiac cellular mechanics and identifying of redundant model components.