Clenbuterol

Clenbuterol is a drug initially developed and researched for long term treatment of breathing conditions as bronchospastic syndrome in mild to moderate bronchial asthma. The medicine is sympathomimetic amine used as fast and effective bronchodilator. The drug does not recover a patient from the disease, but provides emergency one time help to ease breathing during acute episodes of asthma.

Clenbuterol — what is it?

Clenbuterol is also referred to as simple and shortened Clen. It is a beta-2 agonist which is in its structure and pharmacological effect similar to such elements as epinephrine and salbutamol. The drug performs much more powerful stimulating and thermogenic (heat producing) effects. The intake of medicine stimulates aerobic endurance, central nervous system, blood pressure and transfer of oxygen in the tissues under load.

The drug boosts the rates at which an athlete body is able to metabolize deposited fats. Clen boosts basal metabolic rate of the athlete. The medicine is commonly used as bronchodilator and as tocolytic for stimulation of relaxation of smooth muscles.

Clenbuterol is not approved by FDA for several alleged reasons. Some consider that Clenbuterol does not perform potentially easing and useful effect for treatment asthmatic conditions in comparison to other drugs approved for treatment of such conditions. However the drug has become widely applicable in sports in weight loss and fat burning cycles and in preparation for competitions. Since the efficacy of Clenbuterol as endurance and performance enhancer is not proved, still it helps the athletes on Clenbuterol cycles to work less hard with the same effect. Under smaller loads Clenbuterol ensures more sweating and burning more calories.

Information from the drug manufacturer

Clenbuterol is manufactured by Sopharma Pharmaceuticals and is positioned on the drug market as the medicine for long term treatment and control of bronchospastic syndrome. The drug is available only in the form of tablets for oral route of administration. Each pill contains 0,02mg of active component — clenbuterol hydrochloride.

The tests of Clenbuterol, which are conducted by the manufacturer, prove the drug efficiency for treatment of such conditions as:

atopic and non-atopic bronchial asthma

bronchospasms which are strain-induced

chronic spastic bronchitis

The drug is approved for adults and children over 6 years old. Daily dosages for mild to moderate cases of asthmatic conditions are two pills a day (morning and evening). After reaching success the maintenance dosage of Clenbuterol is 0,01mg (half a pill) twice a day (daily dosage equals 1 tablet). The therapeutic dosage of Clenbuterol should be reduced with improvement of conditions and symptoms.

Among contraindications to intake of Clenbuterol the manufacturer lists the next conditions:

hypersensitivity to the medicine

tachycardia

thyrotoxicosis

various arrhythmias

cardiomyopathy

pregnancy

Among Clenbuterol side effects which the manufacturer warns about there are:

insomnia

psyche and mental disorders

headaches and migraines

excessive sweating

excessive anxiety

sudden rapid jumps of blood pressure

urine retention

The manufacturer does not recommend to withdraw or pause the treatment if side effects are present. A user needs only to reduce one time or daily dosage. This can be splitting an average daily dosage into more intakes (two, three, four) or reducing a daily dosage following an average double intake scheme.

Is Clenbuterol a dope? Legal status

Clenbuterol is not an FDA approved drug. This means that it is not allowed for administration in the United States. However the drug is legally available for administration for treatment of asthmatic and bronchial conditions in other countries. The pills are available as with so without doctor’s prescription.

Clenbuterol is not a component of any approved therapeutic drug for athletes. The medicine is on the list of prohibited components to use in sports. Moreover, the FDA bans giving Clenbuterol to animals which are raised for further consumption for people.

Still many athletes use the medicine to boost fat burning in preparation cycles for competitions and to raise endurance. In short, Clenbuterol is not officially approved for athletes and the drug is banned by many international sports authorities with International Olympic Committee. If an athlete is caught using Clenbuterol as a dope as the medicine enhances performance and endurance of an athlete.

Another way to get safe and original Clenbuterol of true pharmaceutical grade is from research chemical laboratories. These organizations officially research chemicals and supply users and participants of the research with the medicines. This is legal. Mind, that Clenbuterol is a powerful stimulating medicine and must be taken strictly keeping to the Clenbuterol cycles which will be described in the next sections.

How Clenbuterol works: the mechanism of action

Being a beta-2 agonist, Clenbuterol acts as a powerful fat burner binding to the beta-receptors of II type in fat and muscle tissues of the body of an athlete. After binding to the receptors, Clenbuterol ignites a chain reaction of natural biochemical processes which as a result lead to the boosting of synthesis of cyclic adenosine monophosphates. The cyclic adenosine monophosphates in their turn activate enzymes which mobilize fatty acids from adipocytes (big cells of fat tissues).

When Clenbuterol acts on beta 2 adrenoreceptors of the presynaptoc membranes, an athlete gets an increase of production of noradrenaline and adrenaline – two natural substances performing the most powerful fat burning effect. This medicines boosts the level of main metabolic processes by 20-30% from the initial level.

Clenbuterol suppresses the action of lipoprotein lipase. As a result of such action the process of fat depositing to the fat tissues turns impossible. By acting on the beta 2 adrenoreceptors of the central nervous system, this medication boosts the secretion of hormones of thyroid gland which are the only fat burning natural chemicals produced by human body.

Clenbuterol produces another unique effect. Apart from being a potent fat burner, Clenbuterol also performs a pronounced anticatabolic effect protecting the muscles of the athlete from damaging. This means that during weight loss and fat burning Clenbuterol cycles you can be sure that you do not lose muscle mass and your weight loss is performed with only burning of fats deposited in your body.

An extensive study proved that anticatabolic effect of the medicine is performed due to the blocking of Ca2+dependent and ubiquitin proteasomal protein breakdown.

Another study of 2012 conducted by Francesca Wannenes and Loretta Magni proved the ability of Clenbuterol to block the mechanisms of atrophy of muscles. A newer study of 2014 proved that beta-agonists (catechol amines), which are released during intense physical workouts, induce CREP-mediated transcription through the activation of its obligate coactivators CRTC2 and Crtc3.

Unlike catabolic activity which is usually related to the function of sympathetic nervous system, the activation of proteins Crtc/CREB in skeletal muscles during trials leads to the enhancement of anabolic processes and to the boost of production of of protein.

Due to the mentioned above mechanisms Clenbuterol performs moderate anabolic effect which is proved by human tests and extensive research of the human body response to the action of the medicine. The same effect is proved with practical use of the medicine in bodybuilding by professional athletes.

Human subject research of Clenbuterol

The research of 2015 conducted by Lee P. has become one of the most reliable proofs of beta-agonists’ efficacy of administration human body. The analogues of Clenbuterol in a daily dosage of 60 microgram stimulated anabolism, raised the synthesis of protein with no side effects and adverse reactions of the body in general and from the part of cardiovascular system in particular. Moreover, the same effects of Clenbuterol and its analogues were present in female subjects as well.

Top proven in use effects of Clenbuterol

This section lists the effects of Clenbuterol in short avoiding professional terminology:

fast fat burning and weight loss

enhancement of power, performance and endurance

rise of body temperature

healthy decrease of appetite

psyche activation

anticatabolic effect

anabolic effect

The drug performs the lowest frequency of side effects performance. The practice of administration of Clenbuterol in bodybuilders and other athletes proves that no irreversible side effects develop during the Clenbuterol cycles for men and women. The wide range of advantages and positive effects on body, safety of the medicine as well as low chance for side effects have made Clenbuterol one of the best fat burners for athletes.

How to use the drug for weight loss

Clenbuterol can be used for weight loss and in the fat burning cycles. Beginning athletes mistake these two types of cycles. Normally weight loss is aimed at sufficient mass loss in beginning athletes. In this type of cycle it is almost impossible to prevent muscle mass loss. With Clenbuterol weight loss cycle can be more effective for fat and safe for lean muscle mass. Due to its effects the drug prevents muscle tissues from damaging and makes muscle loss almost impossible.

Clenbuterol must be administered very carefully for weight loss cycles. Male users must take from 120 to 140 microgram of the medicine as a daily dosage. To achieve the best effect a daily dosage is recommended to be split into three to four even intakes. Mind that the recommended dosage is average, and each user must adjust an effective dosage for each individual weight loss cycle considering the aims of the cycle and the initial body parameters.

Female users commonly are recommended to take 80 to 100 microgram of Clenbuterol as a daily dosage following the same recommendation of splitting a dose into three to four intakes in even intervals of time.

Each Clenbuterol cycle must be carefully weighed and considered to avoid possible side effects. Normally a cycle of Clenbuterol for weight loss in athletes takes up to two weeks (14 days). After that period a human body commonly adjusts to the action of the medicine due to tolerance of receptors on which the drug affects. This leads to loss of efficacy of Clenbuterol. Professional athletes and users of Clenbuterol recommend to make a pause of 14 days and to start Ketotifen instead (the first generation noncompetitive h1-antihistamine and mast cells stabilizer). Without this component in Clenbuterol cycle the efficacy of the key drug will be low and the achieved effect will be lost during a pause which is necessary to avoid receptor tolerance and adjustment. If you do not want to include Ketotifen into Clenbuterol cycle then the pause must be much longer. The efficacy of termination of Clenbuterol cycle was proved during extensive studies in 1990s.

To boost the efficacy of Clenbuterol cycle is possible only with Ketotifen included in the cycle. However there is another way to eliminate adjustment and receptor tolerance which is a pulse cycle. This type of Clenbuterol cycle suggests two days of intake of Clentbuterol and two days of pause. However this Clenbuterol cycle scheme is less effective than with Ketotifen.

To eliminate side effects and to supply your body with all necessary elements and nutrients you must take enough of protein (synthetic and natural with foods you consume), BCAA and other cortisol blockers to improve the results and to boost the efficacy of the medicine. Mind that Clenbuterol cycle will give you zero results without diets and nutrition specifically developed for athletic weight loss and fat burning.

The study of 2012 has proved the integrated total effect of Clenbuterol taken in complex cycle with anabolic steroids. This also proves the need to include this medicine by the end of anabolic steroid cycle. This issue is quite disputable and is argued by many professionals. The matter is that the complex of Clenbuterol with anabolic steroids in a single cycle boosts the risk of cardiac hypertrophy.

Clenbuterol cycle without Ketotifen

Mind, that this is an average scheme of intake of the medicine in an average Clenbuterol cycle. Individual dosages may vary according to the response of your body to the intake of the drug.

The dosage of Clenbuterol must progressively increase during the first week of the cycle. An optimum time for intake of the medicine is the first part of the day or early morning as taking the tablet in the second part of the day or before bed may cause insomnia or troubled sleeping. Moreover human subject studies prove that the efficacy of Clenbuterol in the morning hours is much higher. With the dosage increase, please, start taking a daily dosage into split intake of two even parts at certain planned intervals of time. The best way is the first intake in the early morning and the second intake right at noon.

A possible scheme of intake of the drug in the Clenbuterol cycle can be the next:

1st day – 20 microgram of Clenbuterol

2nd day – 40 microgram of Clenbuterol

3rd day – 60 microgram of Clenbuterol

4th day – 80 microgram of Clenbuterol

5th day – 100 microgram of Clenbuterol

days 6 to 12 – 120 microgram of Clenbuterol

13th day – 80 microgram of Clenbuterol

14th day – 40 microgram of Clenbuterol

a pause

Clenbuterol cycle with Ketotifen

Ketotifen is anti-allergic medicine which performs an effect of prevention of receptors developing tolerance to the action of Clenbuterol. This property of Clenbuterol has been proved with many extensive studies and human subject research cases.

With Ketotifen included in the Clenbuterol cycle you may increase the effect of weight loss and fat burning by 10-20% and to prolong the cycle up to 8 weeks. In addition Ketotifen will help to reduce the psyche stimulation and excitement, tremor of the limbs, to eliminate insomnia and increased heartbeat.

The scheme of intake of Clenbuterol with Ketotifen may be the next:

1st day – 20 microgram of Clenbuterol

2nd day – 40 microgram of Clenbuterol

3rd day – 60 microgram of Clenbuterol

4th day – 80 microgram of Clenbuterol

5th day – 100 microgram of Clenbuterol + 1mg of Ketotifen

days 6 to 27 – 120 microgram of Clenbuterol + 2mg of Ketotifen

28th day – 80 microgram of Clenbuterol + 2mg of Ketotifen

29th day – 50 microgram of Clenbuterol + 1-2mg of Ketotifen

30th day – 33-35 microgram of Clenbuterol + 1mg of Ketotifen

a pause at least of two weeks

Mind that the drugs must be taken separately. The best way is to part Clenbuterol taken in the morning and Ketotifen taken at the evening.

What benefits of Clenbuterol are there for athletes?

Clenbuterol raises the metabolism and prevents muscles from damaging during weight loss and fat burning cycles, thus the weight loss turns more effective with no need of excessive working on muscles. Clenbuterol ensures excessive sweating under minor loads, thus burning even more calories during regular cycle workouts.