Associations between interleukin-1 gene polymorphisms and sepsis risk: a meta-analysis

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BMC Medical Genetics

, 15:8

Bacterial and fungal diseases

Abstract

BackgroundPrevious epidemiological studies have presented conflicting evidence regarding associations between interleukin-1 IL-1 polymorphisms and sepsis susceptibility. We have performed a meta-analysis to evaluate possible associations between IL-1 polymorphisms and sepsis risk.

MethodsEligible literature was retrieved from PubMed, Embase and Web of Knowledge databases until Jun 15, 2013. The pooled odds ratio OR and 95% confidence interval CI were calculated using random-effects model in the overall and subgroup analysis based on ethnicity, sepsis severity and quality score.

ConclusionsOur meta-analysis indicated that IL-1A-889, IL-1B + 3954 and IL-1RN VNTR might be associated with sepsis susceptibility. However, further studies with larger sample sizes and from homogenous populations would be necessary to validate these findings.

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