RARA Monoclonal Antibody (763)

RARA Antibody (MA1-4668)

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the performance of our antibodies with the InvitrogenTM
antibody performance guarantee. If an InvitrogenTM antibody
doesn't perform in your experiment as described on our website
or datasheet, we'll replace the product at no cost to you, or
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Product Details

Bioinformatics

Documents

Synthetic peptide corresponding to the N-terminal region of human RARA conjugated to KLH

Conjugate

Unconjugated

Form

Liquid

Purification

Protein G

Storage buffer

0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/ml BSA, 50% glycerol

Contains

no preservative

Storage Conditions

-20° C, Avoid Freeze/Thaw Cycles

Tested Applications

Dilution *

Western Blot (WB)

1:1000

* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the
product for use in their own experiment using appropriate negative and positive controls.

Product Specific Information

This antibody is predicted to react with bovine, canine, guinea pig and mouse based on 100% sequence homology.

This antibody is specific for the ~48 kDa RXR-1 protein.

Background/Target Information

Retinoic Acid (RA; active metabolite of vitamin A) plays a prominent role in regulating the transition of proliferating precursor cells (such as carcinoma cells and neuronal precursors) to postmitotic differentiated cells (Joshi et al., 2005). The Retinoid X Receptors (RXRs) family (RXR alpha, beta, and gamma), preferentially bind 9-cis -RA and regulate gene transcription by forming heterodimers with a second family of RA receptors. RAs have been suggested to potentially play a therapeutic role in cervical cancer (Abu et al., 2005). RAs are known to play key roles in neuronal development and an increasing body of evidence indicates that retinoid signaling may regulate synaptic plasticity and associated learning and memory behaviors (Lane and Bailey, 2005).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.