Search Tag: heart muscle

Thomas Jefferson University has announced implantation of the first Optimizer® Smart investigational device in a patient enrolled in a new study entitled Impulse Dynamics FIX-HF-5CA Continued Access Study. The device implantation was performed by interventional cardiologist Steven Roberts, MD, at Jefferson Torresdale Hospital’s Heart Center. ...
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Large cardiac-muscle patches created from human cells have been tested on large animals in a heart attack model, with results showing the patches significantly improved recovery from heart attack injury, according to a study published in the journal Circulation. The results are a step closer to the goal of treating human heart attacks by suturing cardiac-muscle...
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Researchers at Texas Heart Institute's Cardiomyocyte Renewal Lab have found a new way to help improve heart function following heart failure. Using a mouse model, the researchers were able to reverse severe heart failure by silencing the activity of Hippo, a signalling pathway that can prevent the regeneration of heart muscle. Their work is published...
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An acute heart attack (myocardial infarction) is a "systemic" condition with an impact upon the whole body and triggers responses in other organs, such as liver and spleen, according to new research published in the journal Oncotarget. The study is the first to scientifically describe the full picture of a myocardial infarction, enhancing our understanding...
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Researchers at UT Southwestern Medical Center have
identified a cell that replenishes adult heart muscle by using a new cell
lineage-tracing technique. The study is published online in Nature .
Most cardiomyocytes don’t replenish themselves after a
heart attack or other significant heart muscle damage but these researchers
have identified a cell...
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A Boston Children's Hospital study, published in Science Translational Medicine , shows that the first six months of life is the best time to stimulate heart muscle cell regeneration (cardiomyocyte proliferation). "Our results suggest that early administration of neuregulin may provide a targeted and multipronged approach to prevent heart failure...
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Researchers at UT Southwestern Medical Center have found that long-term use of a left ventricular assist device (LVAD) by patients with heart failure may induce regeneration of heart muscle by preventing oxidative damage to a cell-regulator mechanism. Their study appears online in the Journal of the American College of Cardiology . The study looked...
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A new study provides evidence challenging the current consensus in cardiology that peak myocardial oedema (heart muscle swelling) only occurs immediately after a myocardial infarction (MI) or heart attack. In the study, researchers discovered a second wave of swelling and inflammation which occurs within a week of a heart attack. The discovery of this...
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By merging stem cell and 'organ-on-a-chip' technologies Harvard scientists have, in a world premiere, successfully grown functioning human heart tissue that carries an inherited cardiovascular disease. A major development for personalised medicine, this research, which was published in Nature Medicine, provides working proof that laboratory-based...
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As cardiovascular disease remains the Western world’s leading cause of death, heart failure is the category registering the fastest incidence increase over the past ten years. Pathological hypertrophy, defined as the heart muscle’s growth as its attempt to increase its output, is the stage that precedes heart failure, yet not all hypertrophy...
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