Not because it's one of the Christian rock band's biggest hits since its release in May 2010 or that it's the title track of the Newsboys' highest debuting record — No. 4 on the Billboard 200.

“It's definitely ‘Born Again' because of what it represents on so many levels,” said Frankenstein, the band's keyboardist. “Being born again in our faith is so significant of course, and also the parallels to the band and starting over.”

Newsboys went through a major restart in 2009, when former dcTalk member Michael Tait replaced longtime member Peter Furler, a move that was initially met with mixed reviews.

Three years later, Newsboys are wrapping up the American leg of the God's Not Dead tour, one of its longest and most successful ever, with some 150 dates. San Antonio will serve as the final stop when the band plays at Trinity's Laurie Auditorium at 7 p.m. Sunday. Building 429, Luminate and newcomer Grace Campbell also are on the bill.

Frankenstein, who joined Newsboys in 1996 and is the band's longest continuous member, said change is nothing new for Newsboys. In 1997, Furler replaced original vocalist John James. And there have been other changes, including the departure of popular bassist Phil Joel in 2006.

“The transition was difficult at the time,” Frankenstein said of Tait's addition. “But it's not even an issue anymore. It's been in place long enough now.”

Part of the challenge was that Newsboys had just finished “In The Hands of God,” and were planning to tour when Furler announced his departure. Frankenstein, drummer Duncan Phillips and guitarist Jody Davis weren't ready to throw in the towel, but were back in the studio sooner than expected to record “Born Again” with Tait at the helm.

“That transitional period took about a year,” Frankenstein said. “A lot of times we would show up to a festival or a show and people hadn't even heard there was a change. It is the Christian music industry, after all, so it was a little hard to get the word out in the media.

“We knew we had to make a record right away with Michael on it. That was kind of daunting. It was like turning the Titanic around. We had to walk out on stage, explain the change and introduce (Tait).”

Frankenstein said the band would play the show and wasn't quite sure how to take the crowd's reaction, which ranged from total acceptance to those questioning whether the project would work.

“But we chipped away at the record and felt it came together,” he said. “And when the ‘Born Again' single came out, it was kind of the end of all the questions.”

Fans and critics took to the song and the album, which they were able to showcase while touring with Winter Jam, one of the nation's largest traveling Christian-music festivals, playing to nearly half a million fans in a five-month stretch.

“Born Again” also set the stage for the follow-up “God's Not Dead,” which was released a year ago.

“These last four or five years have been the most enjoyable time,” Frankenstein said. “There aren't many bands that get the chance to start over. It's much more enjoyable as an artist to feel you are pursuing a path than just trying to hold on to what you had in the past.”

And he said that's the way life is, too; “scripturally everyone must be born again.”