Background

There is little knowledge about the consumption of alcohol among Chinese and Norwegian older adults aged 65 years and over. The aim of this study was to investigate the prevalence and factors related to alcohol consumption among older adults in China and Norway.

Methods

The Chinese Longitudinal Healthy Longevity Survey (CLHLS) data in 2008–2009 conducted in China and The Nord-Trøndelag Health Study data in 2006–2008 (HUNT3) conducted in Norway were used. Mulitvariable logistic regression was used to test the factors related to alcohol consumption.

Results

The prevalence of participants who drink alcohol in the Chinese and Norwegian sample were 19.88% and 46.2%, respectively. The weighted prevalence of participants with consumption of alcohol in the Chinese sample of women and men were 7.20% and 34.14%, respectively. In the Norwegian sample, the prevalence of consumption of alcohol were 43.31% and 65.35% for women and men, respectively. Factors such as younger age, higher level of education, living in urban areas, living with spouse or partner, and better health status were related to higher likelihood of alcohol consumption among Norwegian older women and men; while reported better health status and poorer life satisfaction were related to higher likelihood of alcohol consumption among Chinese. In addition, rural males and older females with higher level of education were more likely to consume alcohol.

Conclusion

The alcohol consumption patterns were quite different between China and Norway. Besides economic development levels and cultures in the two different countries, demographic characteristics, socioeconomic status, overall health status, and life satisfaction were associated with alcohol consumption as well.

Alcohol is a natural stimulant used in cultures across the globe, but the patterns of alcohol consumption differ across ethnic groups [1]. Cultural factors play an important role for drinking behavior [2], and prosperity is often associated with higher usage [3].

The consumption of alcohol is common among people aged 18 years or older in developed countries, such as Norway [4]. It is often linked to social events and special occasions, but also to everyday life such as relaxation at leisure time [5]. In Norway, individuals’ drinking patterns are quite stable regarding alcohol consumption per capita, increasing slightly from below 6 litres of pure alcohol per year in 1981 to 6.7 litres of pure alcohol per year in 2010 [6]. Alcohol consumption per capita (APC) is defined as the per capita amount of alcohol consumed in litres of pure alcohol in a given population [6]. In Norway, the intake of alcohol decreases with age in adult population [7–9]. The proportion of older people being abstinent from alcohol consumption is lower than before [7, 8, 10–12].

In China, considered to be a developing country, alcohol consumption is also a part of the culture. Alcohol consumption culture in China has been established for thousands of years [13, 14]. Chinese culture emphasizes social drinking, such as on the occasions of festivals, celebrations, and business meetings. Chinese culture has long promoted alcohol consumption, especially among men. Men who are capable of consuming a large quantity of alcohol are perceived as masculine [15, 16]. In addition, drinking is perceived to have the function of easing tension, relieving fatigue and facilitating social exchanges in social gatherings [16, 17]. China is undergoing rapid economic development and urbanization, and alcohol production and availability has increased over the past few decades; recorded alcohol consumption per capita rose from below 2 litres of pure alcohol per year in 1981 to 5.0 litres of pure alcohol per year in 2010 [6]. In China, the prevalence of alcohol consumption has been reported higher in younger age groups than in older groups [18, 19], and the prevalence of no consumption of alcohol increased with older age [18].

The consumption of alcohol is tied to regulations and rules which reflect each country’s alcohol policy [20] and the norms of society [20, 21]. There is no regulation forbidding alcohol consumption among adults in these two countries. China does not have enforceable legal regulations about drinking age, home-made alcohol beverages, and when or where alcoholic beverage can be sold [22]. However, there are several regulations covering these behaviors in Norway [23]. In addition, consumption of alcohol (versus no consumption) may be related to socioeconomic factors as well as to health status and life satisfaction. In Norway, adults in urban areas are more likely to be current drinkers, which means they have drunk in the recent 12 months, compared with those living in rural areas. Men are also more likely than women to be current drinkers [24, 25]. But in China, there are different findings about the relationship between rural/urban residency and the consumption of alcohol [18, 26]. In China, the consumption of alcohol among adults has previously been found more prevalent among those with lower level of education both for urban and rural areas [26]. In a more recent study, the prevalence of alcohol consumption was higher among adults with high education than among those with low education, but the analysis was not adjusted for confounders [18]. In Norway, alcohol consumption has been found to be more common in populations with higher education, in better economic status, and in older adults [27]. In a British study about alcohol consumption in older people, those who experienced a better-perceived health status and had a fairly active and sociable lifestyle were more likely to consume alcohol [28]. As far as we know, the knowledge about relationships between alcohol consumption and level of education, health status as well as life satisfaction is scarce in older adults in both China and Norway.

We know that older adults are at increased risk of harm from alcohol consumption due to physiological changes associated with aging, such as having a lower tolerance to alcohol, suffering from chronic illnesses, taking medications, or having functional impairments [29]. However, there are few studies about the consumption of alcohol in older adults in both countries [30, 31]. Exploring the prevalence of alcohol consumption and factors related to drinking among older adults is therefore desirable in providing significant knowledge for health care policy makers and professionals, so adequate steps toward a healthy aging can be taken in the years to come. There is a great need to conduct research in this area [12, 32]. In addition, alcohol consumption is related to culture and may differ across different levels of socioeconomic development. China and Norway have different cultural environments and levels of socioeconomic development. A comparative study of these two countries may provide better understanding of the impact of socioeconomic status and culture on alcohol consumption and help to identify potential modifiable factors about drinking.

The aim of the present study was to examine the prevalence and factors related to alcohol consumption among older adults in China and Norway.

For this study, we performed a secondary data analysis using two large cross-sectional studies conducted in China and Norway at approximately the same time.

Samples from each data set

The Chinese Longitudinal Healthy Longevity Survey (CLHLS) in 2008–2009 selected participants from counties and cities in 22 of China’s 31 provinces. The population in the 22 provinces represents 85% of the total population of China. The study targeted institutionalized and community-living older adults. All centenarians from the selected areas who agreed to participate were included in the study. Based on gender and place of residence (i.e., living in the same street, village, city, or county) for a given centenarian, randomly selected octogenarians and nonagenarians were also sampled. This matched-recruitment procedure resulted in an over-sampling of the oldest old and older men. In the CLHLS, a weight of age–sex–urban/rural residence in the sample with the distribution of the total population in the sampled 22 provinces was employed to reflect the unique sampling design [33–35]. Older adults living in institutions were excluded in this analysis. In total, about 16,255 community dwelling residents aged ≥65 years were included. The unweighted mean age of the total sample was 87.4 (SD 11.4). The number of unweighted male participants was 6884 (42.4%), and the unweighted female participants was 9371 (57.6%).All participants in this study sample answered the main question of interest, consumption of alcohol.

The Nord-Trøndelag Health Study in 2006–2008 (HUNT3) was conducted over a study period of 2 years. The Nord-Trøndelag Health Study is one of the largest health studies ever performed in Norway. HUNT3 was the third cross-sectional HUNT study which was completed between October 2006 and June 2008. Nord-Trøndelag is one of 19 counties in Norway. Nord-Trøndelag county had a population size of 128,694 in 2006. In many aspects, Nord-Trøndelag is considered fairly representative of Norway (geographically, and regarding economy, industry, sources of income, trends in work related disability, age distribution, morbidity and cause specific mortality) [36]. All adult residents (aged ≥20 years) in the Nord-Trøndelag County were asked to participate in the study. In all, 11,545 residents (5461 men) of 12,255 residents (5610 men) aged 65 and older participated and answered questions on alcohol consumption. In total, 816 did not answer the main question of interest, i.e. about alcohol consumption. Those not responding were more often women, living alone and having high age than those responding to the question (p < 0.01). Due to missing information on individual independent variables, the N varied from 11,545 to 9631 in this study. The mean age was 73.7 (SD 6.3) years, with an age range from 65 to 101 years. The rate of participation decreased with age from 71% among people aged 60–69 years to 18% among the oldest aged 90–99 years [37, 38]. The participants were individuals who could meet at an examination station. In this case, those with the most severe conditions and alcohol problems are underrepresented [39]. Older adults living in institutions were not included.

Measures

The dependent variable was alcohol consumption. Each dataset contained questions directly pertaining to alcohol consumption as well as variables potentially related to consumption of alcohol (i.e. self-rated general health, life satisfaction and socio-demographic information).

CLHLS had a question about alcohol consumption: “Do you drink alcohol at present?” Consumption of alcohol was coded as 1 when the participant answered “drink alcohol at present”. HUNT 3 had a question about consumption of alcohol: “How often in the last 12 months did you drink alcohol?” Consumption of alcohol was coded as 1 when the participant answered about once a month or more (including 4–7 times a week, 2–3 times a week, about once a week, or 2–3 times a month).

Socio-demographic information such as age at the time of survey completion, gender, education level, marital status (living spouse or partner versus not), and residence (rural versus urban living) was collected in both studies. CLHLS had years of schooling as a continuous variable on education. HUNT3 only had education as a categorical variable, not a continuous one. We recoded the years of schooling in CLHLS into a categorical variable in order to compare with HUNT 3. The coding was as following: Illiteracy = 0 years of schooling, elementary school and middle school = 1–9 years of schooling, high school = 10–12 years of schooling, and college and university = more than 12 years of schooling. CLHLS had illiterate participants, but HUNT3 didn’t have such an education category. Each nation used their own definitions of rural and urban areas [40, 41]. Urban and rural areas in the Chinese study were self-reported by the participants according to a strictly enforced residential permit system in China [34]. Rural and urban areas in the Norwegian study were self-reported by the responders and described in previous studies [40, 42].

Perceptions of general health were assessed with one self-reported question. The Chinese overall health status variable, “How do you rate your health at present?”, had five response categories ranging from 1 (very good) to 5 (very poor). This item had been used in previous Chinese studies [34, 43]. The Norwegian general health item, “How is your health at the moment?”, had four response categories ranging from 1 (very good) to 4 (very poor). The item has been used in several Norwegian studies [40, 42]. We reversed the coding of overall health on both surveys so that a higher score reflected a better health status.

Life satisfaction was assessed with one item in each dataset. The Chinese item asked “How do you rate your life at present?”, and had five response categories that ranged from 1 (very good) to 5 (very poor). This item had been used in previous Chinese studies [44, 45]. The Norwegian item, “How do you think about your present life situation?”, had seven response categories that ranged from 1 (extremely satisfied) to 7 (extremely dissatisfied). This item has been used in several Norwegian studies, both in hospital samples and population-based studies [34, 38, 40, 46].We reversed the coding of this item on both surveys so that a higher score reflected better satisfaction with life.

Statistical analyses

The consumption of alcohol in the Chinese and Norwegian samples of women and men was presented as percentages. Multivariable logistic regression was used to test the dependent variable (consumption of alcohol coded as 1 versus no consumption of alcohol coded as 0). The explanatory variables with possible relationship to the consumption of alcohol were gender, age, level of education, marital status (living or not living with spouse or partner), living in rural (versus urban) areas, self-rated overall health and life satisfaction. We conducted univariable logistic regression analyses first. We then included those variables that were significantly associated with the dependent variable (P < 0.05), and those of interest to this study in the multivariable logistic regression analyses. Odds ratios and 95% confidence intervals are reported. In CLHLS, there was a category of “unable to answer” for self-rated overall health and life satisfaction. We treated “unable to answer” as a missing value. Weights were applied to reflect the unique sampling design of the CLHLS. The analyses about the CLHLS and HUNT3 samples were conducted using the programs of SAS 9.3 (SAS Institute, Inc., Cary, NC, USA), and SPSS version 22.0 (SPSS, Chicago, Ill, USA), respectively.

The prevalence of alcohol consumption for the Chinese and Norwegian samples were 19.88% (weighted) and 46.2%, respectively. The weighted prevalence of participants with consumption of alcohol in the Chinese sample were 7.20% and 34.14% for women and men, respectively. In the Norwegian sample, the prevalence of consumption of alcohol were 43.31% and 65.35% for women and men, respectively. The prevalence of consumption of alcohol by gender, socio-demographic conditions, perceived health, and life satisfaction for both samples are described in Table 1.

Table 1

The prevalence of consumption of alcohol in CLHLS and HUNT3 samples

women

men

China (weighted)

Norway

China (weighted)

Norway

Variables

Total N

alcohol consumption

Total N

alcohol consumption

Total N

alcohol consumption

Total N

alcohol consumption

n

Prev. (%)

n

Prev. (%)

n

Prev. (%)

n

Prev. (%)

8686

625

7.20

6084

2641

43.31

7723

2637

34.14

5461

3569

65.35

Age

65–74

5127

322

6.28

3633

1875

51.61

5106

1855

36.32

3455

2490

72.07

75–84

2714

233

8.59

2054

667

32.47

2229

677

30.37

1756

976

55.58

85+

845

70

8.24

397

99

24.94

388

105

27.12

250

103

41.20

Achieved level of education ina

1 Illiteracy

5444

373

6.84

0

1721

550

31.39

0

2 Elementary school and middle school

2910

224

7.71

3504

1346

38.41

4965

1807

36.40

2122

1261

59.43

3 High school

229

11

4.95

1214

646

53.21

661

175

26.47

1836

1242

67.65

4 College and University

89

11

11.84

637

396

62.17

367

956

26.06

817

647

79.19

Living inb

URBAN areas

3697

282

7.63

3712

1742

46.93

3268

941

28.79

3292

2242

68.10

RURAL areas

4989

343

6.87

2311

857

37.08

4456

1696

38.06

2115

1281

60.57

Marital statusc

No living spouse or partner

4728

334

7.06

2946

1038

35.23

1964

683

34.77

1308

787

60.17

Living spouse or partner

3958

291

7.35

3136

1603

51.12

5760

1954

33.93

4151

2780

66.97

Overall health statusd

Poor

1489

68

4.56

2452

914

37.28

1111

283

25.49

1899

1129

59.45

Life satisfactione

Poor

606

41

6.75

63

25

39.68

388

105

26.99

64

42

65.62

a, b, c, d, eHaving missing value in the CLHLS and HUNT3 study

Findings from logistic regression analyses on factors associated with alcohol consumption are shown in Tables 2 and 3. For Chinese women, those aged 75–84 years and aged 85+ were more likely to drink alcohol than those aged 65–74 (OR = 1.572, 95% CI = 1.298–1.904; OR = 1.564, 95% CI = 1.132–2.160, respectively); but for Chinese men and Norwegians (both women and men) those aged 75–84 years were less likely to consume alcohol than those aged 65–74 years (OR = 0.792, 95% CI = 0.709–0.885, OR = 0.569, 95% CI = 0.499–0.648, OR = 0.490, 95% CI = 0.428–0.560, respectively). Similar findings were found for the oldest old Chinese men, and the oldest old Norwegians aged 85+ (women and men), in comparison to those aged 65–74. The odds ratios were 0.689 (95% CI = 0.537–0.884), 0.534 (95% CI = 0.407–0.702), and 0.311 (95% CI = 0.231–0.420), respectively. For those who completed high school education or college and university education, Norwegian women and men were more likely to consume alcohol than those who completed elementary school and middle school. Chinese illiterate older women were less likely to drink than those with elementary school and middle school education. But for Chinese men, illiterate individuals and those with high school or college and university education were less likely to drink than those with elementary school and middle school education. For those living in rural areas, Chinese men were more likely to consume alcohol than those living in urban areas (OR = 1.471, 95% CI = 1.327–1.631), but Norwegian women and men were less likely to consume alcohol than those living in urban areas (OR = 0.728, 95% CI = 0.646–0.821, OR = 0.760, 95% CI = 0.667–0.865, respectively). For those living with spouse or partner, Norwegian women and men were more likely to consume alcohol compared with those without living with spouse or partner(OR = 1.510, 95% CI = 1.336–1.707, OR = 1.277, 95% CI = 1.097–1.487, respectively); however, no significant relationship was found between marital status and alcohol consumption among Chinese women and men. Those with better overall health were more likely to consume alcohol both in the Chinese and Norwegian sample, regardless of gender. Chinese women and men with better life satisfaction were less likely to consume alcohol compared to those with poor life satisfaction (OR = 0.889, 95% CI = 0.792–0.998, OR = 0.910, 95% CI = 0.849–0.974, respectively), but no similar associations were found among Norwegian women and men samples.

This study examined the prevalence of alcohol consumption among older women and men in China and Norway, and factors (i.e., socio-demographic status, perceived overall health, and life satisfaction) associated with alcohol consumption in the population. The alcohol consumption patterns were quite different in the two countries.

The prevalence of alcohol consumption in Norway was higher than the prevalence in China both for older women and men. We assume that the differences between the prevalence of alcohol consumption in China and Norway may be partially explained by different levels of economic development between these two countries. According to the most recent WHO data, greater economic wealth was broadly associated with higher levels of alcohol consumption and lower abstention rates [3]. The alcohol consumption levels in developed countries such as WHO European Region and Region of the Americas were the highest across the globe, while the alcohol consumption level in China was lower than WHO European Region and Region of the Americas [6]. For the past 30 years, although China has been undergoing rapid economic development and urbanization, the alcohol consumption per capita in China is still lower than that of Norway’s [6]. Culture may also play an important role. In China, most alcohol consumption occurs at social events such as festivals, weddings, and business interactions. Cultural norms encourage social drinking and discourage solitary drinking [47]. In Norway and the western countries, consumption of alcohol is often not only linked to social events and special occasions, but also to everyday life like relaxation at leisure time [5].

Furthermore, we found that men had a higher prevalence of alcohol consumption than women in both countries. This finding is consistent with previous studies [6, 26, 48] and may be partially due to cultural values and norms in these countries [49]. In Chinese culture, there is a long history of alcohol consumption among men. Chinese men have more social interactions to drink than women. In rural areas of China, men are more likely to do the heavy labor than women; hence, men may drink to relieve physical fatigue [48]. We believe that culture may play a less prominent role in gender differences in Norway [49], both in rural and urban areas. In addition, purchasing power is strongly associated with alcohol consumption. In China, men have more economic power than women. Evidence suggest that the gender gap in socioeconomic status is much smaller in Norway than in China. Thus, it is expected that the proportion of older women with alcohol consumption is higher in Norway than in China.

Among participants aged 65 and over, older age was negatively associated with alcohol consumption in Chinese men and Norwegian men and women. It is consistent with the findings from studies conducted in United States, Denmark and United Kingdom [8, 9, 50]. The reason why people with older age decreased the incidence of drinking may be higher sensitivity to alcohol, suffering from chronic diseases, or using medication among older adults [29, 51]. But Chinese women aged 75–84 years and 85+ years had higher likelihood of alcohol consumption than those aged 65–74 years. One explanation for this may be that older Chinese women often believe that drinking has a good effect on health and lack of awareness of alcohol-related health problems, making them more likely to consumption alcohol [14] .

Similar to previous studies conducted in Norway, our analysis found that higher level of education was positively associated with alcohol consumption among Norwegian older women and men [52, 53]. Nordfjærn’s study showed that Norwegian individuals with high education had lower levels of alcohol abstinence (4%) than those with basic education (7%), and high education was also related to more consumption [52]. Brunborg’s study showed that income was weakly associated with risk of heavy drinking, but higher education was associated with greater risk of heavy drinking [53]. Education is normally covering the socio-economic status in older people in Nordic social democratic countries with a welfare system. The Norwegian people with higher education were more likely to have better socioeconomic status, able to afford alcohol, and more often consume alcohol in social events [15, 28, 54, 55]. For the Chinese sample, older women with higher level of education (e.g., elementary school and middle school education) had a higher likelihood of alcohol consumption compared to illiterate women. But for Chinese men, illiterate individuals and those with high school or college and university education were less likely to drink than those with elementary school and middle school education. The associations between education and alcohol consumption between China and Norway were different. It may be related to the different levels of education distribution among the two countries’ samples. The Norwegian sample had a higher level of education particularly in college and university level, but the Chinese sample had a lower level of education with a high percentage of illiteracy and a low percentage of college and university.

Living in rural areas was negatively related to alcohol consumption among Norwegian women and men. The difference in drinking patterns of Norwegian women and men between rural and urban areas was supported by other studies from developed countries [2, 56, 57]. The reasons may be a combination of different factors, such as socioeconomic status, disparate custom, and religious norms, which the present study did not explore. One reason is that people living in urban area of developed countries are more likely to have better socioeconomic status, so they can better afford alcohol. The fact that a higher proportion of people in rural areas have higher prevalence of abstinence of alcohol may be partially due to conservative religious beliefs [56]. However, the relationship between rural/urban living and alcohol drinking was reversed in Chinese men. Older Chinese men living in rural areas were more likely to be a drinker when compared to those living in urban areas. This phenomenon may be partially attributable to the different cultural and legal backgrounds and health system characteristics. In China, there is a lack of comprehensive public policy on alcohol consumption. The Government has few restrictions for people to produce or access alcohol [16]. Home-made or underground–brewed rice wines are commonly used in rural areas of China because they are more affordable than other industry-produced alcohol beverages [14]. The Chinese traditional customs, popular in rural areas, believe that moderate drinking can benefit people’s health. The Chinese Traditional Medicine theory holds the belief that “alcohol is the leader of all kinds of medicine, and can guide other medicines to the place of disease” [47, 58], so many rural residents put herbs in alcohol and drink the alcohol to treat some diseases and symptoms such as back and leg pain caused by rheumatism [14]. The disparities of health systems in rural and urban areas of China exacerbate this situation. The relative lack of medical care facilities and professionals in rural areas make it more difficult to get access to health care. Hence, the rural populations are more likely to rely on the Chinese Traditional Medicine belief and treat medical problems using alcoholic beverages by themselves. There was no significant difference of alcohol use between rural and urban areas among Chinese women. This finding may be most likely due to the small percentage of alcohol consumption among Chinese women, and thus we are not able to test the rural/urban differences due to a small sample.

Living with a spouse or partner was positively associated with using alcohol in Norwegian women and men, which was supported by the results of a previous German study [55]. But this association was not significant in China. It may be due to the different drinking cultures. Chinese people drink more frequently at social occasions, but not with their spouse or partner at home. However, alcohol consumption is a part of relaxation and leisure activity in Norway. People often drink and enjoy time together with their spouse or partner.

Our study found that better self-reported health status was positively associated with high alcohol consumption. This was consistent with previous studies [47, 48]. Health status may be an important factor in impacting older adults’ decisions whether to drink or not. Older adults with better overall health may think they can sustain alcohol use and choose to drink, while those with poor health statuses may choose not to use alcohol [55, 59]. Alternatively, older adults with better health statuses who continue to drink might be a result of healthy survival effect.

This study found that poorer life satisfaction was related to higher likelihood of alcohol consumption among Chinese women and men. This finding was supported by previous studies [60, 61]. However, this relationship was not significant among Norwegian women and men, which may indicate that the other factors included in the analysis (socioeconomic and health conditions) rather than satisfaction in life had greater importance.

The strengths of this study were the comparative design of the two datasets that enable us to examining the prevalence and factors associated with alcohol consumption among older adults in a developed country (Norway) and a developing country (China). The CLHLS Study conducted in China and the HUNT3 Study conducted in Norway both had relatively large sample size and reliable results.

Limitations

There were several limitations in the present analysis. The definitions of current drinking were slightly different in the two surveys. The variable about current drinking in the CLHLS study was a dichotomous variable, while the variable about current drinking in HUNT3 was frequency of alcohol consumption. We had no information about the type of alcohol beverage, frequency of drinking, amount of alcohol intake, and alcohol-related disorders from the datasets, therefore we were not able to investigate the relationships between alcohol consumption and health consequences in China and Norway. Further studies focusing on drinking type, frequency, quantity, and alcohol-attributable disease and injury between developed and developing countries are needed. Older adults living in institutions were not included in HUNT3. CLHLS included both institutionalized and community-living older adults. In order to compare the prevalence of alcohol consumption in older adults in China and Norway, we excluded the institutionalized older adults in CLHLS, which might result in a selection bias. This study was conducted among community-dwelling older adults. The findings may not be generalizable to those living in institutions.

This is the first comparative study reporting the prevalence and related factors of alcohol consumption among older adults in a developed country (Norway) and a developing country (China). We found that alcohol consumption patterns and factors related to alcohol consumption among older women and men were different between the two countries. The overall prevalence of alcohol consumption in Norway was higher than that in China. The prevalence of alcohol consumption among older men was higher than that among older women both in China and Norway. Younger age, higher education, living in urban areas, living with spouse or partner and better health status were related to higher likelihood of alcohol consumption among Norwegian older women and men. Living in rural areas, better health status and poorer life satisfaction were related to higher likelihood of alcohol consumption among Chinese older men. Older age, higher education, better health status and poorer life satisfaction were related to higher likelihood of alcohol consumption among Chinese older women. These findings suggest that policy makers and healthcare professionals need to have a better knowledge about culture-related factors in order to promote healthy aging, but also to take the demographic characteristics, socioeconomic status as well as economic development levels into account when considering alcohol consumption.

Acknowledgments

The HUNT Research Centre (Faculty of Medicine, Norwegian University of Science and Technology NTNU), Nord-Trøndelag County Council and the Norwegian Institute of Public Health funded the Nord-Trøndelag Health Study (The HUNT Study).We thank Dr. Huashuai Chen for his interpretation about the CLHLS database. We would like to thank Katherine Wang for her editorial assistance.

Ethical approval and consent to participate

The CLHLS study was approved by research ethics committees of Duke University and Peking University (IRB00001052–13074). The HUNT3 Study was approved by the Norwegian Regional Committee of Medical Research Ethics (4.206.250 dated 06.04.2006, 2015/1640/REK nord, dated 18.08.2015). All participants provided written informed consent. No experimental interventions were performed.

Funding

None.

Availability of data and materials

The Norwegian data used in the present study belongs to the HUNT Research Centre and the Norwegian Institute of Public Health. Information about the data source and available data are found at http://www.ntnu.no/hunt/fakta. The data will not be shared due to HUNT and Norwegian regulations.

Author’s contributions

JL designed concept, analyzed data of the Chinese sample, interpreted data and prepared manuscript. BW designed concept, interpreted outcome and reviewed manuscript. GS designed concept and reviewed manuscript. SK designed concept and reviewed manuscript. A-SH designed concept, analyzed data of the Norwegian sample, interpreted data, prepared and reviewed manuscript. All authors have read and approved the manuscript, and ensure that this is the case.

Consent for publication

Not Applicable.

Competing interests

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.

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