If a patient has colon cancer and there's suspicion that methastasis may be present in various other organs, will the program from database 'colon cancer' deal with these metas? Or it's necessary to run colon cancer presets and other cancer presets?

Typically, when you have a particular type of cancer metastasize to another location, you have the same cells now just in another location. Therefore, colon cancer cells in the lungs is not lung cancer (a mutation of the lung cells), and should be treated as such.