SciClone Announces Enrollment of First Patient in Its Phase 2 Trial of SCV-07 in Hepatitis C

FOSTER CITY, CA -- (Marketwire) -- 10/21/09 -- SciClone Pharmaceuticals, Inc. (NASDAQ: SCLN) today announced the enrollment of its first patient at the Atlanta
Gastroenterology Associates in Atlanta, GA, in a phase 2 trial of SCV-07
for the treatment of hepatitis C (also known as HCV). This multicenter,
multidose, open-label study is designed to evaluate the safety and
immunomodulatory effects of SCV-07 as a monotherapy or in combination with
ribavirin in non-cirrhotic patients with genotype 1 chronic HCV who have
relapsed after at least 44 weeks of treatment with pegylated interferon and
ribavirin.

"During our previous phase 2A clinical trial of SCV-07 as a monotherapy to
treat patients with chronic hepatitis C infections, we were pleased by the
safety data and were very encouraged by the efficacy signal, namely, a
reduction of viral loads and a corresponding increase in neopterin
concentration in some patients after only seven days of SCV-07
administration," said Friedhelm Blobel, Ph.D., President and Chief
Executive Officer of SciClone. "SciClone is eager to investigate further
SCV-07's potential to enhance the immune response against hepatitis C and
to determine whether the compound is capable of improving the current
standard of care treatment."

"Currently approved therapies for the treatment of HCV can have
significant side effects and often fall short of providing the most
important treatment outcome, sustained viral response," said Kenneth
Sherman, MD, PhD, Gould Professor of Medicine, Department of Internal
Medicine at the University of Cincinnati, and a principal investigator in
SciClone's study. "We are very excited by what appears to be SCV-07's
ability to enhance patients' immune function without adding significant
toxicity. Should ongoing clinical trials show the benefits of adding SCV-07
to ribavirin, it has the potential to become incorporated into standard
treatment practices in the future."

The study, which will monitor biomarkers of immune activation and HCV viral
load dynamics, will include two treatment cohorts of 20 patients each, who
will receive SCV-07 at a dose of either 0.1 mg/kg or 1.0 mg/kg. The
treatment period will be approximately eight weeks long, including four
weeks of SCV-07 monotherapy followed by four weeks of SCV-07 in combination
with ribavirin. In addition, there will be three follow-up visits within
seven weeks after the completion of treatment.

For more information on SciClone's phase 2 trial of SCV-07 in the treatment
of HCV, please visit www.clinicaltrials.gov.

About SCV-07

SCV-07 is a small molecule which stimulates the immune system through
inhibition of STAT3-dependant signaling and the resulting effects on
T-helper 1 cells, which are essential for clearance of viral infections.
SCV-07 has shown a good safety profile in several early stage clinical
trials in healthy volunteers and subjects with HCV at various doses.
SciClone is also carrying out a phase-2, randomized, double-blinded,
placebo-controlled trial of SCV-07 for the treatment of oral mucositis in
patients with head and neck cancers undergoing chemo-radiation. The topline
results from this trial are expected to be announced in the first half of
2010.

SCV-07 is protected by composition of matter patents as well as multiple
method of treatment patents. SciClone has exclusive worldwide rights to
SCV-07 outside of Russia, where the molecule has recently been approved for
stimulation of depressed immune systems.

About the Hepatitis C Virus

HCV is a blood-borne viral disease which causes inflammation of the liver.
The World Health Organization estimates that 170 million people worldwide
are infected with HCV, and the Centers for Disease Control estimates that
approximately 8 to 10 million people are infected with HCV throughout the
U.S. and Europe. Of these patients, approximately 85% are chronically
infected, and the persistent liver inflammation in chronically infected
patients can develop serious complications including cirrhosis of the
liver, liver failure, and hepatocellular carcinoma. Only about half of all
naive patients treated with current therapy achieve a sustained viral
response, and SciClone estimates nearly 1 million HCV patients in the
United States alone have failed or will fail current therapy. The market
for HCV therapeutics in the three major economic regions of the United
States, Europe and Japan is estimated to total approximately $3 billion
currently and is expected to grow to approximately $10 billion by 2014.

About SciClone

SciClone Pharmaceuticals (NASDAQ: SCLN) is a profit-driven, global
biopharmaceutical company with a substantial international business and a
product portfolio of novel therapies for cancer and infectious diseases.
SciClone is focused on continuing international sales growth, a
cost-containing clinical development strategy, and expense management.
ZADAXIN (thymalfasin or thymosin alpha 1) is sold in over 30 countries for
the treatment of hepatitis B (HBV) and hepatitis C (HCV), certain cancers
and as a vaccine adjuvant. SciClone's pipeline of drug candidates includes
thymalfasin, in preclinical studies as an enhancer of novel H1N1 flu
vaccines; thymalfasin for stage IV melanoma, for which SciClone has reached
agreement with the FDA on the design of a phase 3 trial; SCV-07 in a phase
2 trial for the delay of onset of severe oral mucositis in patients
receiving chemoradiation therapy for the treatment of cancers of the head
and neck; and SCV-07 in a phase 2 trial for the treatment of HCV.
SciClone has exclusive commercialization and distribution rights to DC
BeadTM in China, where the product is under regulatory review. The Company
also has commercialization and distribution rights to an anti-nausea drug
ondansetron RapidFilmTM in China and Vietnam, for which it is seeking
regulatory approval. For additional information, please visit
www.sciclone.com.

Forward-looking statements

The information in this press release contains forward-looking statements
including our expectations and beliefs regarding the timing and results of
our clinical trials. You are urged to consider statements that include the
words "may," "will," "would," "could," "should," "might," "believes,"
"estimates," "projects," "potential," "expects," "plans," "anticipates,"
"intends," "continues," "forecast," "designed," "goal," or the negative of
those words or other comparable words to be uncertain and forward-looking.
These statements are subject to risks and uncertainties that are difficult
to predict and actual outcomes may differ materially. These risks and
uncertainties include our forward-looking statements because of the
inherent uncertainties, including in the timing of clinical trial events
such as including patient enrollment, requirements of, and future actions
of, the U.S. Food and Drug Administration, the fact that experimental data,
and clinical results derived from studies with animals or a limited group
of patients, and as well as comparisons with other clinical trials may not
be predictive of the results of larger studies and, therefore, such
experimental or clinical data are not necessarily predictive indicative of
the efficacy or safety or the results of larger studies and clinical
trials. Please also refer to the other risks and uncertainties described in
SciClone's filings with the Securities and Exchange Commission. All
forward-looking statements are based on information currently available to
SciClone, and SciClone assumes no obligation to update any such
forward-looking statements.

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