Role of Lgr5-Positive Cells in Colorectal Cancer
Researchers report expression of Lgr5, a stem cell marker for the intestine and hair follicle, in some of the colorectal cancer (CRC) cells in the patients. Transduction of several CRC cell lines with this virus selectively killed Lgr5-positive cells, resulting in significant inhibition of the CRC cell growth in vitro and in vivo. [Tumor Biol] Abstract