Blocking Enzyme May Allow Remylination

Blocking a certain enzyme in the brain may help repair the brain damage associated with MS and certain other neurological disorders, research from Oregon Health & Science University (OHSU) suggests.

The enzyme, called a hyaluronidase, is highly elevated in brain lesions of people with MS and in the nervous systems of animals with an MS-like disease, according to the OHSU research team. The team is led by Larry Sherman, Ph.D., who is a professor of cell and development biology at OHSU and a senior scientist in the Division of Neuroscience at the Oregon National Primate Research Center.

"What this means is that we have identified a whole new target for drugs that might promote repair of the damaged brain in any disorder in which demyelination occurs,"Sherman said. "Any kind of therapy that can promote remyelination could be an absolute life-changer for the millions of people suffering from MS and other related disorders."

Sherman cautioned that the discovery does not necessarily signal a cure for MS. Many other factors can contribute to the problems associated with MS and other demyelinating diseases, he said. But discovering the actions of this enzyme - and finding a way to block it- "could at the very least lead to new ways to promote the repair of brain and spinal cord damage either by targeting this enzyme alone or by inhibiting the enzyme in conjunction with other therapies.”

The researchers found that by blocking hyaluronidase activity, they could promote myelin-forming cell differentiation and remyelination in mice with MS-like disease. Most significantly, the drug that blocked hyaluronidase activity led to improved nerve cell function.

Sherman's lab has been studying MS and other conditions where myelin is damaged for more than 14 years. In 2005, he and his research team discovered that a sugar molecule, called hyaluronic acid, accumulates in areas of damage in the brains of humans and animals with demyelinating brain and spinal cord lesions. Their findings at the time suggested that hyaluronic acid itself prevented remyelination by preventing cells that form myelin from differentiating in areas of brain damage.

The new study shows that the hyaluronic acid itself does not prevent the differentiation of myelin-forming cells. Rather, breakdown products generated by a specific enzyme that chews up hyaluronic acid - a hyaluronidase - contribute to the remyelination failure.

The next step is to develop drugs that specifically target this enzyme. "The drugs we used in this study could not be used to treat patients because of the serious side effects they might cause," said Sherman. "If we can block the specific enzyme that is contributing to remyelination failure in the nervous system, it would likely cause few, if any, side effects."

Sherman and other researchers at the ONPRC are uniquely positioned to test newly developed drugs for their safety and effectiveness in nonhuman primates at ONPRC that spontaneously develop an MS-like disease. If they find a drug that is effective in these monkeys, they will be in a good position to test such drugs in patients.

The study was published in the online edition of the Annals of Neurology.

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