Abstract

Co-conservation (phylogenetic profiles) is a well-established method for predicting
functional relationships between proteins. Several publicly available databases use
this method and additional clustering strategies to develop networks of protein interactions
(cluster co-conservation (CCC)). CCC has previously been limited to interactions within
a single target species. We have extended CCC to develop protein interaction networks
based on co-conservation between protein pairs across multiple species, cross-species
cluster co-conservation.