Background: Mitochondria are suggested to be important organelles for cancer initiation and promotion. This study was designed to evaluate the prognostic value of MTC02, a marker for mitochondrial content, in prostate cancer.

Methods: Immunohistochemistry of using an antibody against MTC02 was performed on a tissue microarray (TMA) containing 11,152 prostate cancer specimens. Results were compared to histological phenotype, biochemical recurrence, ERG status and other genomic deletions by using our TMA attached molecular information.

Mentions:
MTC02 immunostaining was located in the cytoplasm of prostate cells. Cancer cells showed higher staining intensities as compared to normal prostate glands. No differences in the staining patter of the different prostate cancer subtypes were observed. In prostate cancer, MTC02 immunostaining was found in 96.5% of the 8,412 analyzable prostate cancers and was considered strong in 46.5%, moderate in 34.6% and weak in 15.4% of tumors. Representative images demonstrating MTC02 expression in prostate cancer tissue are given in Figure 1. Strong MTC02 staining was associated with advanced pathological tumor stage, high Gleason grade, positive nodal involvement (p < 0.0001 each), positive surgical margin (p = 0.0005), and early PSA recurrence if all cancers were jointly analyzed (p < 0.0001).

Mentions:
MTC02 immunostaining was located in the cytoplasm of prostate cells. Cancer cells showed higher staining intensities as compared to normal prostate glands. No differences in the staining patter of the different prostate cancer subtypes were observed. In prostate cancer, MTC02 immunostaining was found in 96.5% of the 8,412 analyzable prostate cancers and was considered strong in 46.5%, moderate in 34.6% and weak in 15.4% of tumors. Representative images demonstrating MTC02 expression in prostate cancer tissue are given in Figure 1. Strong MTC02 staining was associated with advanced pathological tumor stage, high Gleason grade, positive nodal involvement (p < 0.0001 each), positive surgical margin (p = 0.0005), and early PSA recurrence if all cancers were jointly analyzed (p < 0.0001).

Background: Mitochondria are suggested to be important organelles for cancer initiation and promotion. This study was designed to evaluate the prognostic value of MTC02, a marker for mitochondrial content, in prostate cancer.

Methods: Immunohistochemistry of using an antibody against MTC02 was performed on a tissue microarray (TMA) containing 11,152 prostate cancer specimens. Results were compared to histological phenotype, biochemical recurrence, ERG status and other genomic deletions by using our TMA attached molecular information.