"Focal seizures are episodes of pathological brain activity that appear to arise from a
localised area of the brain. The onset patterns of focal seizure activity have been studied
intensively, and they have largely been distinguished into two types { low amplitude
fast oscillations (LAF), or high amplitude spikes (HAS). Here we explore whether these
two patterns arise from fundamentally different mechanisms. Here, we use a previously
established computational model of neocortical tissue, and validate it as an adequate
model using clinical recordings of focal seizures. We then reproduce the two onset
patterns in their most defining properties and investigate the possible mechanisms
underlying the different focal seizure onset patterns in the model. ..."
Reference: 1 .
Wang Y, Trevelyan AJ, Valentin A, Alarcon G, Taylor PN, Kaiser M (2017) Mechanisms underlying different onset patterns of focal
seizures PLoS13(5):e1005475

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