Femández Ordóñez

On this page you can read or download Femández Ordóñez in PDF format. We also recommend you to learn related results, that can be interesting for you. If you didn't find any matches, try to search the book, using another keywords.

Parkinson disease (PD) is a progressive neurodegenerative disorder that aﬀects 1% of the population over 55 years of age. The pathologic hallmark of the disease is the loss of dopaminergic neurons in the Substantia Nigra pars compacta (SNc) and the presence of intracytoplasmic inclusions named Lewy bodies, formed mainly by α-synuclein and ubiquitin. In the striatum, there is a loss of dopamine (DA) and its metabolites homovanillic acid and 3,4-dihydroxyphenylacetate [1–3]. The dopaminergic loss in the .

The percentage figure is, most likely, arbitrarily arrived at and not appropriate for the specific project. There is a tendency to double count risks because some estimators are inclined to include contingencies in their best estimate. A percentage addition still results in a single-figure prediction of estimated cost, implying a degree of certainty that is simply not justified. The percentage added indicates the potential for detrimental or downside risk; it does not indicate any potential for cost .