DNA Sequencing - Technologies, Markets and Companies

This report briefly reviews basics of human genome variations, development of sequencing technologies, and their applications. Current large and small sequencers are described as well as companies developing them. Various applications of sequencing are described including those for genetics, medical diagnostics, drug discovery and cancer. Next generation sequencing technologies, both second and third generations, are reviewed. Companies developing software for analysis of sequencing data are also included. Selected academic institutes conducting research in sequencing are also listed.

Current market is mostly for research applications and future markets will be other applications related to healthcare. The value of DNA sequencer market in 2014 is described with estimates for 2019 and 2024. Various methods and factors on which market estimates depend are described briefly. Markets are tabulated according to geographical areas as well as applications. Small sequencers form the basis of SWOT (strengths, weaknesses, opportunities, threats) analysis. Several marketing strategies have been outlined.

The report includes profiles of 128 companies involved in sequencing and their 138 collaborations. The report text is supplementd by 39 tables, 18 figures and 450 selected references to the literature.

6. Applications of Sequencing in HealthcareIntroductionApplications of sequencing in molecular diagnosticsClinical exome sequencingACE Clinical Exome testDiagnosis and screening of genetic disordersCarrier screening using high-throughput NGSCNV sequencing for diagnosis of chromosomal disordersRole of WGS in screening of newbornsWGS for pre-implantation genetic diagnosis in IVFGuidelines for use of sequencing for diagnosisIncidental findings on clinical sequencingNGS for diagnosis of CNS infectionsNGS for detection of solid organ transplant rejectionNGS for forensic diagnosisCompanies developing sequence-based molecular diagnosticsSequencing in cardiovascular disordersInherited cardiomyopathiesExome sequencing and mutations associated with risk of coronary heart diseaseSequencing for study of the human immune systemSequencing for investigating drug-virome interactions in organ transplantsNGS-based HLA typingHigh-throughput HLA genotyping with deep sequencingApproaches to NGS-based HLA typingApplications of NGS-based HLA typingPharmaceutical applications of sequencingDrug discovery and developmentResequencingRNA profilingQuantitative selection of aptamers through sequencingNext generation sequencing and drug safetySequencing in aging researchWGS for the study of supercentariansCurrent status and future prospects of clinical applications of NGSNeeds of the clinical market for NGSSequencers for the clinical marketChallenges for clinical applications of NGSACMG clinical laboratory standards for NGSApplications of human transcriptome array in clinical trialsFuture trends in clinical sequencingRare Diseases Genomes ProjectEthical aspects of sequencing

8. Sequencing in Genetic DisordersIntroductionApproaches to sequencing in genetic disordersDNA sequencing for prenatal disordersHigh-throughput sequencing in Undiagnosed Disease Program at NIHSequencing of maternal plasma for detection of fetal aneuploidySequencing for study of transposonsSequencing genomes of the newborn to screen for genetic disordersStudy of rare variants in pinpointing disease-causing genesTandem repeat variability for detection of genetic factors in diseasesWhole genome sequencing for diagnosis of genetic disordersWhole exome sequencing for diagnosis of genetic disordersWhole genome sequencing of a human fetus from maternal plasmaGenetic disorders investigated by sequencingBartter syndromeCHARGE syndromeDiGeorge syndromeDiscovery of the gene for Miller syndromeDiscovery of the gene for Kabuki syndromeFamilial combined hypolipidemiaFamilial thoracic aortic aneurysmHereditary blindnessNeurofibromatosis type 1Noonan syndromeProteus syndromeSyndrome of hypogonadotropic hypogonadism, ataxia, and dementiaSyndrome of polyarthritis nodosa vasculopathyX-linked disorder due to N-terminal acetyltransferase deficiency

9. Sequencing in Neurological and Psychiatric DisordersIntroductionSequencing in Alzheimer diseaseSequencing in Parkinson diseaseSequencing in Huntington’s diseaseSequencing in Wilson’s diseaseSequencing in ataxiasSequencing in epilepsyEpileptic encephalopathySequencing for mutations in familial amyotrophic lateral sclerosisSequencing of whole genome in Charcot-Marie-Tooth diseaseSequence-based detection of a variant of Lambert-Eaton syndromeSequencing in muscular dystrophySequencing in acute brain injury due to hemorrhageSequencing for mutations in autism spectrum disordersSequencing for diagnosis of intellectual disabilitySequencing in neurodevelopmental disordersNGS for identifying mutations in RNA geneSequencing in attention-deficit/hyperactivity disorderSequencing in schizophrenia and bipolar disorderSequencing in drug addiction

10. Applications of sequencings in infectionsIntroductionSequencing genomes of microbesDNA sequencing for study of bacterial epidemicsGenome sequencing of H. influenzae to identify population structureRole of sequencing in cholera epidemicsRole of sequencing in epidemic of Shiga toxin-producing E. coliSequencing study of Salmonella emergence in Sub-Saharan AfricaSequencing of ancient specimes from past epidemicsSequencing for tracking hospital acquired infectionsSequencing for investigation of MRSA outbreaksRole of sequencing in tracking a hospital infection of K. pneumoniaeRole of whole genome sequencing in identification of C. difficileHuman Microbiome ProjectRole of sequencing in the management of bacterial infectionsPyrosequencing of microbial flora in leg ulcersSequencing for study of antibiotic resistance in bacteriaSequencing for predicting the virulence of MRSASequencing the human gut microbiome for new immunomodulatory moleculesSequencing of gut microbes in obesitySequencing for mapping genomic variation in Mycobacterium ulceransSequencing for mapping genetic interactions in bacteriaSequencing of DNA from single cells of bacteriaSequencing of the fungal genomesSequencing for detection of drug resistance in Plasmodium falciparumSequencing of human salivary microbiomeSequencing in the management of HIV/AIDSLong read sequencing for personalizing HIV therapyNGS for studying neuroAIDSSequencing plus immunological analyses to study HIV evolutionSurveillance of drug resistance in HIV-infected individualsSequencing in the management of Ebola virus infectionSequencing in the management of HBVSequencing in the management of HCVSequencing genome of Lassa fever virusSequencing genome of a rhabdovirus associated with acute hemorrhagic feverSurveillance of H1N1 influenza A virus using resequencing arraysNext generation sequencing for antibacterial therapeutic discovery

11. Role of Sequencing in Personalized MedicineIntroductionTechnologies relevant to sequencing and personalized medicineWhole genome sequencing and personalized medicineWhole exome sequencing and personalized disease riskPersonal Genome ProjectRole of sequencing in personalized cancer managementStandardization of sequencing for personalized medicineRegulating genomic testing in the era of personalized medicineFuture of sequencing and personalized medicine

12. Markets for SequencersIntroductionMethods used for estimation of sequencer marketsCurrently marketed sequencersAcademic and research markets for sequencingFactors affecting future development of sequencing marketsFuture needs and support of researchBioinformatics in relation to sequencingReducing the cost of human genome sequencingUS Government-supported research on sequencingContribution of American Recovery and Reinvestment ActGenome X Prize FoundationInnovations to reduce cost of whole genome sequencingCommercial aspects of low cost genome sequencingGenome sequencing suitable for personalized medicineGlobal sequencing marketsGlobal markets for sequencersMarkets for sequencing services according to geographical regionsGlobal sequencing markets according to applicationsGlobal sequencing markets according to therapeutic areasMarket trends for NGSChallenges to developing market for sequencersRecommendations

13. Companies Involved in SequencingIntroductionMajor players in sequencingProfiles of companies involved in sequencingCollaborations

Professor K. K. Jain is a neurologist/neurosurgeon by training and has been working in the biotechnology/biopharmaceuticals industry for several years. He received graduate training in both Europe and USA, has held academic positions in several countries and is a Fellow of the Faculty of Pharmaceutical Medicine of the Royal Colleges of UK. Currently he is a consultant at Jain PharmaBiotech. Prof. Jain is the author of 415 publications including 16 books (2 as editor) and 48 special reports, which have covered important areas in biotechnology, gene therapy and biopharmaceuticals.

Quick Help:
A copy of the report will be emailed to you and a printed copy will be shipped to you. The Electronic copy is sent in PDF format. This is a single user license, allowing one specific user access to the product.

MAKING A DIFFERENCE

CHARITY PARTNERS

KEEP UP TO DATE

ON ALL THE LATEST PRODUCTS

Enter your email address:

TESTIMONIALS

Thank you very much for the quick report delivery and response for all my requests and inquiries. You and your team worked very efficiently to help me get the report I was looking for.
The on-line purchase process also worked flawlessly and left a very professional and reliable impression to me using your services for the first time – and certainly not the last! Thanks!Dr. Arno AvelaApplication Marketing ManagerBorealis Polymers OY