Per unit price or other underlying value of transaction computed pursuant to Exchange Act Rule 0-11 (set forth the amount on which the filing fee is calculated and
state how it was determined):

(4)

Proposed maximum aggregate value of transaction.

(5)

Total fee paid.

¨

Fee paid previously with preliminary materials.

¨

Check box if any part of the fee is offset as provided by Exchange Act Rule 0-11(a)(2) and identify the filing for which the offsetting fee was paid previously.
Identify the previous filing by registration statement number, or the Form or Schedule and the date of its filing.

(1)

Amount Previously Paid.

(2)

Form, Schedule or Registration State No.:

(3)

Filing Party:

(4)

Date Filed:

2 Pembroke House

Upper Pembroke Street 28-32, Dublin 2, Ireland

(Registered in England & Wales under Company No. 2353920)

NOTICE IS HEREBY GIVEN that the Annual General Meeting of Shareholders of Amarin Corporation plc, a company registered in England and
Wales (the Company), will be held at The Shelbourne Hotel, 27 St. Stephens Green, Dublin 2, Ireland on July 7, 2014 at 2:00 p.m. local time for the purpose of considering and, if thought fit, passing the
following resolutions, each of which will be proposed as ordinary resolutions:

As Ordinary Business

1.

To re-elect Dr. Lars G. Ekman as a director;

2.

To re-elect Dr. James I. Healy as a director;

3.

To elect Mr. John F. Thero as a director;

4.

To hold an advisory (non-binding) vote to approve the compensation of the Companys named executive officers as described in the Compensation Discussion and Analysis section, the tabular disclosure
regarding such compensation, and the accompanying narrative disclosure set forth in the enclosed Proxy Statement; and

5.

To appoint Ernst & Young LLP as auditors of the Company to hold office until the conclusion of the next general meeting at which accounts are laid before the Company and to authorize the audit committee of the
board of directors of the Company to fix the auditors remuneration.

Additional Business

As a public limited company organized under the laws of England and Wales, it is a statutory requirement that the Board lay before the Annual
General Meeting the Companys statutory accounts, which are the annual report and the accounts for the financial year ended December 31, 2013 prepared in accordance with International Financial Reporting Standards (the
Statutory Accounts). The Company does not expect that other items of business will be considered at the Annual General Meeting.

Only shareholders who held shares at the close of business on the record date, April 22, 2014, may vote at the Annual General Meeting,
including any adjournment or postponement thereof. The accompanying Proxy Statement more fully describes the details of the business to be conducted at the Annual General Meeting. After careful consideration, our Board of Directors has unanimously
approved the proposals and recommends that you vote FOR each director nominee and FOR each other proposal described in the Proxy Statement.

The Companys principal executive offices are located at 2 Pembroke House, Upper Pembroke Street 28-32, Dublin 2, Ireland. The registered
office of Amarin Corporation plc is One New Change, London EC4M 9AF, England. A copy of the Companys Annual Report for the year ended December 31, 2013, which contains audited consolidated financial statements, prepared in accordance with
U.S. generally accepted accounting principles, and other information, accompanies this Notice and the enclosed Proxy Statement.

Important Notice of Internet Availability. The accompanying Proxy Statement and Annual Report will also be available to the
public at http://investor.amarincorp.com.

We look forward to seeing you at the Annual General Meeting.

Sincerely,

/s/ John F. Thero

John F. Thero

President and Chief Executive Officer

April 30, 2014

WHETHER OR NOT YOU EXPECT TO ATTEND THE ANNUAL GENERAL MEETING, PLEASE COMPLETE, DATE, SIGN AND RETURN THE
ENCLOSED PROXY CARD USING THE ENCLOSED RETURN ENVELOPE, AS PROMPTLY AS POSSIBLE IN ORDER TO ENSURE YOUR REPRESENTATION AT THE MEETING. EVEN IF YOU HAVE VOTED BY PROXY, YOU MAY STILL VOTE IN PERSON IF YOU ATTEND THE MEETING. PLEASE NOTE, HOWEVER,
THAT IF YOUR SHARES ARE REPRESENTED BY AMERICAN DEPOSITARY SHARES AND HELD ON DEPOSIT BY CITIBANK, N.A., AS DEPOSITARY, OR IF YOUR SHARES ARE HELD OF RECORD BY A BROKER, BANK OR OTHER NOMINEE AND YOU WISH TO HAVE YOUR VOTES CAST AT THE MEETING, YOU
MUST OBTAIN, COMPLETE AND TIMELY RETURN A PROXY CARD ISSUED IN YOUR NAME FROM THAT INTERMEDIARY IN ACCORDANCE WITH ANY INSTRUCTIONS PROVIDED THEREWITH.

PROXY STATEMENT FOR

2014 ANNUAL GENERAL MEETING OF SHAREHOLDERS

TO BE HELD ON JULY 7, 2014

GENERAL INFORMATION

This
Proxy Statement is furnished in connection with the solicitation of proxies by the Board of Directors (the Board) of Amarin Corporation plc, a public limited company registered in England & Wales
(Amarin or the Company) for use at the Companys 2014 Annual General Meeting of shareholders to be held at The Shelbourne Hotel, 27 St. Stephens Green, Dublin 2, Ireland, on July 7,
2014, at 2:00 p.m. local time for the purpose of considering and, if thought fit, passing the resolutions specified in the Notice of Annual General Meeting. This proxy statement is being mailed to shareholders on or about May 6, 2014.

For a proxy to be effective, it must be properly executed and dated and lodged (together with a duly signed and dated power of attorney or
other authority (if any) under which it is executed (or a notarially certified copy of such power of attorney or other authority)) at the offices of the Companys registrars, Equiniti of Aspect House, Spencer Road, Lancing, West Sussex, UK BN99
6DA (the Registrars) so as to be received by 8:00 a.m. local time on July 4, 2014. Each proxy properly tendered will, unless otherwise directed by the shareholder, be voted FOR the proposals subject to a binding vote,
FOR the nominees described in this Proxy Statement and at the discretion of the proxy holder(s) with regard to all other matters that may properly come before the meeting.

The Company will pay all of the costs of soliciting proxies. We will provide copies of our proxy materials to the depositary for our American
Depositary Shares (Citibank, N.A.), brokerage firms, fiduciaries and custodians for forwarding to beneficial owners and will reimburse these persons for their costs of forwarding these materials. We have engaged Georgeson Shareholder Communications
Inc. to assist us in the distribution and solicitation of proxies for a fee of $9,000 plus expenses. Our directors, officers and employees may also solicit proxies; however, we will not pay them additional compensation for any of these services.
Proxies may be solicited by telephone, facsimile, or personal solicitation.

Shares Outstanding and Voting Rights

Amarin is registered in England & Wales and therefore subject to the Companies Act 2006 (the Companies Act),
which, together with the Articles of Association of the Company (the Articles ), governs the processes for voting at Annual General Meetings. There are a number of differences between English and U.S. law in relation
to voting. At the Annual General Meeting, a resolution put to the vote of the meeting shall be decided on a show of hands unless a poll is demanded by (a) the chairman, (b) at least two shareholders entitled to vote at the meeting,
(c) a shareholder or shareholders representing not less than one-tenth of the total voting rights of all shareholders having the right to vote at the meeting (excluding any voting rights attached to shares that are held as treasury shares) or
(d) a shareholder or shareholders holding shares conferring a right to vote at the meeting being shares on which an aggregate sum has been paid up equal to not less than one-tenth of the total sum paid up on all shares conferring that right
(excluding any shares in the Company conferring a right to vote at the meeting that are held as treasury shares).

Only holders of record
of our ordinary shares of £0.50 each (Ordinary Shares) at the close of business on April 22, 2014 (the Record Date), are entitled to notice of and to vote at the Annual General Meeting.
On the Record Date, approximately 172,906,063 Ordinary Shares were issued and 172,885,984 were outstanding, of which approximately 172,440,450 were held in the name of Citibank, N.A. (the Depositary), which issues Company-sponsored American Depositary Receipts (ADRs) evidencing American Depositary Shares (ADSs) which, in turn, each represent one Ordinary Share. With respect
to all matters to be voted on at the Annual General Meeting, each shareholder present has only one vote unless demand is made for a vote on a poll (in which case each shareholder gets one vote per ordinary share held). The presence, in person or by
proxy, of at least two shareholders who hold shares as of the Record Date will constitute a quorum for the transaction of

1

business at the Annual General Meeting. At any adjournment of the Annual General Meeting, if a quorum is not present within fifteen minutes from the time appointed for such meeting, one person
entitled to be counted in a quorum present at the adjournment shall be a quorum.

Persons who hold Ordinary Shares directly on the Record
Date (record holders) must return a proxy card or attend the Annual General Meeting in person in order to vote on the proposals. Persons who own Ordinary Shares indirectly on the Record Date through a brokerage firm, bank
or other financial institution, including persons who own Ordinary Shares in the form of ADSs through the Depositary (beneficial owners), must return a voting instruction form to have their shares or the shares underlying
their ADSs, as the case may be, voted on their behalf. Brokerage firms, banks or other financial institutions that do not receive voting instructions from beneficial owners may either vote these shares on behalf of the beneficial owners or return a
proxy leaving these shares un-voted (a broker non-vote). ADR holders are not entitled to vote directly at the Annual General Meeting, but an Amended and Restated Deposit Agreement dated as of November 4, 2011, or
Deposit Agreement, exists between the Depositary and the holders of ADRs pursuant to which registered holders of ADRs as of the record date are entitled to instruct the Depositary as to the exercise of voting rights pertaining to the Ordinary Shares
so represented. The Depositary has agreed that it will endeavor, insofar as practicable, to vote (in person or by delivery to the Company of a proxy) the Ordinary Shares registered in the name of Citibank, N.A., in accordance with the
instructions of the ADR holders. In the event that the instruction card is executed but does not specify the manner in which the Ordinary Shares represented are to be voted (i.e., by marking a vote FOR, AGAINST or any other
option), the Depositary will vote in respect of each proposal as recommended by the Board which is described in the Notice of Annual General Meeting. Instructions from the ADR holders must be sent to the Depositary so that the instructions are
received by no later than 10:00 a.m. New York time on July 3, 2014 (the Instruction Date).

The Company has
retained Equiniti of Aspect House to hold and maintain its register of members. Equiniti of Aspect House will be engaged by the Company to send proxy forms to all registered members appearing on that register and to take delivery of completed proxy
forms posted to it in accordance with the details above.

Abstentions and broker non-votes will be counted for the purpose of determining
the presence or absence of a quorum, but will not be counted for the purpose of determining the number of votes cast on a given proposal. The required vote for each of the proposals expected to be acted upon at the Annual General Meeting is
described below:

Ordinary Resolutions

Proposals No. 1 to No. 3Election of directors. Each director nominated for election is elected if (i) on a
show of hands, a majority of shareholders present in person or by proxy and voting on the proposal vote in favor of such director or (ii) on a poll, a majority of the shares present at the meeting in person or by
proxy and voting on the proposal are voted in favor of such director. As a result, abstentions and broker non-votes will have no effect on the vote outcome.

Proposal No. 4Advisory (non-binding) vote to approve the Companys executive compensation. This advisory proposal will
be approved if (i) on a show of hands, a majority of shareholders present in person or by proxy and voting on the proposal vote in favor of the resolution or (ii) on a poll, a majority of the shares present at
the meeting in person or by proxy and voting on the proposal are voted in favor of the resolution. As a result, abstentions and broker non-votes will have no effect on the vote outcome.

Proposal No. 5Approval of independent registered public accounting firm. This proposal will be approved if
(i) on a show of hands, a majority of shareholders present in person or by proxy and voting on the proposal vote in favor of the resolution or (ii) on a poll, a majority of the shares present at the
meeting in person or by proxy and voting on the proposal are voted in favor of the resolution. As a result, abstentions and broker non-votes will have no effect on the vote outcome.

2

We encourage you to vote by proxy by mailing an executed proxy card. By voting in advance of the
meeting, this ensures that your shares will be voted and reduces the likelihood that the Company will be forced to incur additional expenses soliciting proxies for the Annual General Meeting. Any record holder of our Ordinary Shares may attend the
Annual General Meeting in person and may revoke the enclosed form of proxy at any time by:



executing and delivering to the corporate secretary a later-dated proxy; or



voting in person at the Annual General Meeting.

Beneficial owners of our Ordinary Shares and
holders of ADSs representing our Ordinary Shares who wish to change or revoke their voting instructions should contact their brokerage firm, bank or other financial institution or the Depositary, as applicable, for information on how to do so.
Generally, however, beneficial owners of our Ordinary Shares and holders of ADSs representing our Ordinary Shares who wish to change or revoke their voting instructions may do so up until 10:00 a.m. New York Time on the Instruction Date. Beneficial
owners who wish to attend the Annual General Meeting and vote in person should contact their brokerage firm, bank or other financial institution holding Ordinary Shares of Amarin on their behalf in order to obtain a legal proxy which
will allow them to both attend the meeting and vote in person. Without a legal proxy, beneficial owners cannot vote at the Annual General Meeting because their brokerage firm, bank or other financial institution may have already voted or returned a
broker non-vote on their behalf. Record holders of ADSs representing our Ordinary Shares who wish to attend the Annual General Meeting and vote in person should contact the Depositary (and beneficial owners wishing to do the same should contact
their brokerage firm, bank or other financial institution holding their ADSs) to cause their ADSs to be cancelled and the underlying shares to be withdrawn in accordance with the terms and conditions of the Deposit Agreement so as to be recognized
by us as a record holder of our Ordinary Shares.

3

PROPOSALS NO. 1 TO NO. 3

ELECTION OF DIRECTORS

The
Articles provide that, at every annual general meeting, at least one-third of the directors at the time shall retire from office (or, if the number of directors at the time is not a multiple of three, then the number nearest to but not exceeding
one-third shall retire from office). The directors elected at the Annual General Meeting will hold office until their successors are elected and qualified, unless they resign or their seats become vacant due to death, removal, or other cause in
accordance with the Articles.

As described below, the Board has nominated Drs. Ekman and Healy for re-election at the Annual General
Meeting. Each of the nominees have indicated his willingness to serve if elected. Should any of the nominees become unavailable for election at the Annual General Meeting, the persons named on the enclosed proxy as proxy holders may vote all proxies
given in response to this solicitation for the election of a substitute nominee chosen by the Board.

The Articles also provide that any
director appointed to the Board since the 2013 Annual General Meeting shall only hold office until the 2014 Annual General Meeting and shall then be eligible for re-election (but shall not be taken into account in determining the directors who are
to retire by rotation at the 2014 Annual General Meeting).

As described below, Mr. Thero was appointed to the Board in January 2014
and will stand for election at the Annual General Meeting. Mr. Thero has indicated his willingness to serve if elected. Should Mr. Thero become unavailable for election at the Annual General Meeting, the persons named on the enclosed proxy
as proxy holders may vote all proxies given in response to this solicitation for the election of a substitute nominee chosen by the Board.

Nomination
of Directors

The Nominating and Corporate Governance Committee, which acts as the Companys nominating committee, reviews and
recommends to the Board potential nominees for election to the Board. In reviewing potential nominees, the Nominating and Corporate Governance Committee considers the qualifications of each potential nominee in light of the Boards existing and
desired mix of experience and expertise. Specifically, the Nominating and Corporate Governance Committee considers the following minimum criteria: whether the nominee has experience at a strategic or policymaking level in a business, government,
non-profit or academic organization of high standing; whether the nominee is highly accomplished in his or her field, with superior credentials and recognition; whether the nominee is well regarded in the community and has a long-term reputation for
the highest ethical and moral standards; whether the nominee has sufficient time and availability to devote to the affairs of the Company, particularly in light of the number of boards on which the nominee may serve; whether the nominee has a
demonstrated history of actively contributing at board meetings (to the extent that the nominee serves or has previously served on other boards). These criteria are set forth in our Nominating and Corporate Governance Committee Charter. In addition
to these minimum qualifications, the Nominating and Corporate Governance Committee recommends that the Board select persons for nomination to help ensure that: a majority of the Board shall be independent in accordance with NASDAQ rules; each of the
Companys Audit, Remuneration and Nominating and Corporate Governance Committees shall be comprised entirely of independent directors; and at least one member of the Audit Committee shall qualify as an audit committee financial expert as
defined by SEC rules. In addition, the Nominating and Corporate Governance Committee may consider whether the nominee has direct experience in the pharmaceutical, biotechnology or healthcare industries or in the markets in which the Company operates
and whether the nominee, if elected, would assist in achieving a mix of Board members that represents a diversity of background and experience. Although the Nominating and Corporate Governance Committee may consider whether nominees assist in
achieving a mix of Board members that represents a diversity of background and experience, which is not only limited to race, gender or national origin, we have no formal policy regarding board diversity.

4

After reviewing the qualifications of potential Board candidates, the Nominating and Corporate
Governance Committee presents its recommendations to the Board, which selects the final director nominees. Upon the recommendation of the Nominating and Corporate Governance Committee, the Board nominated Drs. Healy and Ekman for re-election as
directors and Mr. Thero for election as a director.

The Nominating and Corporate Governance Committee considers shareholder nominees
using the same criteria set forth above. Shareholders who wish to present a potential nominee to the Nominating and Corporate Governance Committee for consideration for election at a future annual general meeting of shareholders must provide the
Nominating and Corporate Governance Committee with notice of the nomination and certain information regarding the candidate within the time periods set forth below under the caption Shareholder Proposals.

Nominees and Incumbent Directors

The
Nominating and Corporate Governance Committee has recommended, and the Board has nominated, Drs. Ekman and Healy to be re-elected and Mr. Thero to be elected directors at the Annual General Meeting. The following table sets forth the following
information for these nominees and the Companys continuing directors: the year each was first elected a director of the Company, their respective ages and the positions currently held with the Company:

Nominee / Director Name and Year First Became aDirector

Age

Position(s) with the Company

Nominees for Director:

John F. Thero (2014)

53

President, Chief Executive Officer, Director

Lars G. Ekman, M.D., Ph.D. (2008)

64

Director

James I. Healy, M.D., Ph.D. (2008)

49

Director

Continuing Directors:

Jan van Heek (2010)

64

Director

Joseph S. Zakrzewski (2010)

51

Director

Kristine Peterson (2010)

54

Director

Patrick J. OSullivan (2011)

72

Director

David Stack (2012)

63

Director

Directors Nominated for Election

The following persons have been nominated by the Board to be elected as directors at the 2014 Annual General Meeting.

John F. Thero joined Amarin in November 2009. He was promoted to President and Chief Executive Officer, and appointed to the Board,
effective January 2014. Prior to his promotion, he was Amarins President since November 2010 before which he was Amarins Chief Financial Officer. Mr. Thero has more than 20 years of senior financial and operational management
experience, including supporting the growth of life science companies for over 15 years. Mr. Thero has helped manage both the successful commercial growth and the successful sale of companies. In 2007, Mr. Thero was Chief Financial Officer
at ViaCell, Inc., where he helped guide the company to its successful sale. From 2003 to 2007, Mr. Thero was Senior Vice President at Acusphere, Inc., where he oversaw the successful build-out and qualification of manufacturing operations. From
1994 to 2003, in a number of senior positions at Abiomed, Inc., including Senior Vice President Business Operations and Chief Financial Officer, he helped manage the transition from a development-stage company into a commercial entity.
Mr. Thero began his professional career at Arthur Andersen LLP, during which time he became a Certified Public Accountant. The Board believes that Mr. Theros experience in management positions at life sciences companies, as well as
his past experience as Amarins President and Chief Financial Officer, provide him with the appropriate qualifications and skills to serve as a member of the Board.

5

Lars G. Ekman, M.D., Ph.D. joined Amarin as a non-executive director in November 2008, and
was named Amarins lead independent director in October 2011 and Amarins Chairman of the Board effective January 2014. With more than 29 years of experience in the pharmaceutical industry, Dr. Ekman is currently an executive partner
at Sofinnova Ventures and serves as Executive Chairman of Sophiris Bio Inc. (formerly Protox Therapeutics) as well as Chairman of Prothena Biosciences. From October 2008 to 2011 he served as Co-Founder and Chief Executive Officer of Cebix Inc. He
was Executive Vice President and President of Global Research and Development at Elan Corporation plc, from January 2001 to December 2007. Prior to joining Elan, he was Executive Vice President, Research and Development at Schwarz Pharma AG from
February 1997 to December 2000, and prior to that was employed in a variety of senior scientific and clinical functions at Pharmacia, now Pfizer. Dr. Ekman also sits on the Board of Directors of InterMune Inc. and Ocera Therapeutics.
Dr. Ekman is a board-certified surgeon with a Ph.D. in experimental biology and has held several clinical and academic positions in both the United States and Europe. He obtained his Ph.D. and M.D. from the University of Gothenburg, Sweden.
Based on Dr. Ekmans experience within the pharmaceutical industry and his executive experience, specifically his experience as Chief Executive Officer and other executive positions in the biotechnology industry, as well as his service on
boards of directors in the biotechnology industry, the Board believes Dr. Ekman has the appropriate set of skills to serve as a member of our Board.

James I. Healy, M.D., Ph.D. joined Amarin as a non-executive director in May 2008. Dr. Healy has been a General Partner of
Sofinnova Ventures, a venture capital firm, since June 2000. Prior to June 2000, Dr. Healy held various positions at Sanderling Ventures, Bayer Healthcare Pharmaceuticals (as successor to Miles Laboratories) and ISTA Pharmaceuticals, Inc.
Dr. Healy is currently on the board of directors of Hyperion Therapeutics, Inc., Anthera Pharmaceuticals, Inc., InterMune, Inc., KaloBios Pharmaceuticals, Inc., and several private companies. Previously, he served as a board member of Durata
Therapeutics, Inc., CoTherix, Inc. and Movetis NV and several private companies. Dr. Healy holds an M.D. and a Ph.D. in Immunology from the Stanford School of Medicine and holds a B.A. in molecular biology and a B.A. in Scandinavian Studies
from the University of California at Berkeley. The Board believes that Dr. Healys experience in the pharmaceutical industries and investing in life sciences companies, as well as his medical and scientific background, provide him with the
qualifications and skills to serve as a director.

Directors Continuing in Office

Jan van Heek joined Amarin as a non-executive director in February 2010. He is currently a Principal and Partner at BioPoint Group,
where he advises biotechnology and other healthcare companies in commercial strategy development, financing and business development. Prior to establishing BioPoint, Mr. van Heek spent more than 18 years at Genzyme Corporation, most recently as
an Executive Vice President and Senior Advisor to the CEO and senior management team. Mr. van Heek is currently a board member of PanGenetics BV in the Netherlands and was a board member and Chairman of the Audit Committee of ViaCell
Corporation, a U.S. public company, from 2002 until it was sold to Perkin Elmer Corporation in 2007. He received an MBA degree from St. Gallen University in Switzerland and an executive degree from Stanford Business School. Based on Mr. van
Heeks experience within the biotechnology industry and his executive experience, specifically his experience in executive officer positions at other companies in the biotechnology industry, as well as his service on other boards of directors,
the Board believes Mr. van Heek has the appropriate set of skills to serve as a member of our Board.

Joseph S. Zakrzewski
joined Amarin as a non-executive director in January 2010. From November 2010 to December 2013, Mr. Zakrzewski served as Amarins Chief Executive Officer and Chairman of the Board of Directors. From May 2007 to May 2010,
Mr. Zakrzewski served as President and Chief Executive Officer of Xcellerex, a privately held company focusing on commercializing its proprietary next generation manufacturing technology for biotherapeutics and from January 2005 to May 2007,
Mr. Zakrzewski served as the Chief Operating Officer of Reliant Pharmaceuticals. From 1988 to 2004, Mr. Zakrzewski served in a variety of positions at Eli Lilly and Company including as Vice President, Corporate Business Development
from 2003 through 2004. In addition, Mr. Zakrzewski served as a Venture Partner with Orbimed, the worlds largest

6

healthcare-dedicated investment firm, in 2010 and 2011. Mr. Zakrzewski also serves on the Board of Directors of Acceleron Pharma and Insulet Corporation. Mr. Zakrzewski earned a BS in
Chemical Engineering and an MS in Biochemical Engineering from Drexel University as well as an MBA in Finance from Indiana University. The Board believes that Mr. Zakrzewski should serve on our Board based on his knowledge of our Company gained
from his former position as Chief Executive Officer and his substantial experience serving as an executive officer of other pharmaceutical companies, as well as Mr. Zakrzewskis service as a member of boards of directors of other
pharmaceutical companies.

Kristine Peterson joined Amarin as a non-executive director in November 2010. Ms. Peterson has more
than 27 years of pharmaceutical industry experience, including 20 years at Bristol-Myers Squibb, where she was responsible for sales, marketing and general management in a variety of therapeutic areas, including leading the cardiovascular and
metabolic disease business unit. She is currently, and has been since June 2009, Chief Executive Officer at Valeritas, Inc., a medical technology company committed to the development and commercialization of innovative drug delivery solutions, with
its lead product for the treatment of diabetes. Prior to joining Valeritas, Ms. Peterson was Company Group Chair for the biotech business at Johnson & Johnson from May 2006 through June 2009, was an Executive Vice President at
Johnson & Johnson from August 2004 through May 2006 and was Senior Vice President of commercial operations at Biovail Corporation from May 2003 to August 2004. Ms. Peterson is currently a director of Valeritas, Inc., ImmunoGen, Inc.
the Biotechnology Industry Organization and the Greater Philadelphia Life Sciences Congress. Ms. Peterson has an MBA degree in Marketing from the University of Illinois. Based on Ms. Petersons experience within the pharmaceutical
industry and her executive experience, specifically her experience as an executive officer at other companies in the biotechnology industry, as well as her service on other boards of directors in the biotechnology industry, the Board believes
Ms. Peterson has the appropriate set of skills to serve as a member of our Board.

Patrick J. OSullivan joined Amarin as
a non-executive director in December 2011. Mr. OSullivan has more than 40 years of pharmaceutical industry experience, including more than 30 years as Chief Executive Officer and member of the Board of Directors of the LEO Pharma
companies in Ireland and more than 10 years as a member of the Board of Directors of the parent company of the LEO Pharma Group in Denmark. Since 2007 Mr. OSullivan has been a business consultant to the pharmaceutical industry, and he
currently serves as a member of the Board of Directors of Actavis Plc. Mr. OSullivan is a registered pharmacist who earned Bachelor of Commerce and Masters of Business Administration degrees from University College in Dublin. The Board
believes that Mr. Sullivans experience from serving as an officer director of various companies within the pharmaceutical industry, as well as his educational training in business administration, make him a valuable member of our Board.

David Stack joined Amarin as a non-executive director in December 2012. Mr. Stack is currently the President and Chief
Executive Officer of Pacira Pharmaceuticals, Inc. Mr. Stack has been a managing director of MPM Capital since 2005 and a managing partner of Stack Pharmaceuticals, Inc. since 1998. From 2001 to 2004, he was President and Chief Executive Officer
of The Medicines Company. Previously, Mr. Stack was President and General Manager at Innovex, Inc. He was Vice President, Business Development/Marketing at Immunomedics from 1993 until 1995. Prior to that, he was with Roche Laboratories from
1981 until 1993, in various positions including therapeutic world leader in infectious disease and director, business development and planning, infectious disease, oncology, and virology. He currently serves as a member of the board of directors of
Pacira Pharmaceuticals, Inc., PepTx, Inc. and Medivo, Inc. He was a member of the boards of directors of Molecular Insight Pharmaceuticals, Inc. from 2006 to 2010 and BioClinica, Inc. from 1999 to 2010. Mr. Stack holds a B.S. in pharmacy from
Albany College of Pharmacy and a B.S. in Biology from Siena College. The Board believes that Mr. Stacks qualifications to sit on our Board include his extensive experience with pharmaceutical companies, his financial expertise and his
years of experience providing strategic and financial advisory services to pharmaceutical and biotechnology organizations.

7

Vote Required

Each director nominated for election will be elected if (i) on a show of hands, a majority of shareholders present in person or by
proxy and voting on the proposal vote in favor of such director or (ii) on a poll, a majority of the shares present at the meeting in person or by proxy and voting on the proposal are voted in favor of such
director. As a result, abstentions and broker non-votes will have no effect on the vote outcome.

Holders of proxies solicited by this
Proxy Statement will vote the proxies received by them as directed on the proxy card or, if no direction is made, then FOR the election of all the nominees named in this Proxy Statement.

THE BOARD OF DIRECTORS RECOMMENDS A VOTE FOR

EACH OF THE NOMINEES IDENTIFIED ABOVE.

8

PROPOSAL NO. 4

ADVISORY VOTE ON EXECUTIVE COMPENSATION

Background

As recommended by our
shareholders at our 2011 Annual General Meeting and subsequently approved by our Board of Directors, we give our shareholders the opportunity to cast an advisory (non-binding) vote on executive compensation each year (a so-called
say-on-pay vote). At the 2013 Annual General Meeting, the Companys shareholders supported the say-on-pay vote with nearly 95% of the votes cast on the proposal.

The advisory vote on executive compensation is a non-binding vote on the compensation of the Companys named executive
officers, as described in the Compensation Discussion and Analysis section, the tabular disclosure regarding such compensation, and the accompanying narrative disclosure, set forth in this Proxy Statement. The advisory vote on executive
compensation is not a vote on the Companys general compensation policies, compensation of the Companys Board of Directors, or the Companys compensation policies as they relate to risk management. Our philosophy in setting
compensation policies for executive officers has two fundamental objectives: (1) to attract and retain a highly skilled team of executives and (2) to align our executives interests with those of our shareholders by rewarding
short-term and long-term performance and tying compensation to increases in shareholder value. The Remuneration Committee believes that executive compensation should be directly linked both to continuous improvements in corporate performance
(so-called pay for performance) and accomplishments that are expected to increase shareholder value. The Compensation Discussion and Analysis section herein provides a more detailed discussion of the executive compensation program and
compensation philosophy.

The vote under this Proposal No. 4 is advisory, and therefore not binding on the Company, the Board or our
Remuneration Committee. However, our Board, including our Remuneration Committee, values the opinions of our shareholders and, to the extent there is any significant vote against the executive officer compensation as disclosed in this Proxy
Statement, we will consider our shareholders concerns and evaluate what actions may be appropriate to address those concerns.

Shareholders will be asked at the Annual General Meeting to approve the following resolution pursuant to this Proposal No. 4:

RESOLVED, that the shareholders of the Company vote in favor of a non-binding, advisory vote approving the compensation of the
Companys named executive officers.

Vote Required

This advisory proposal will be approved if (i) on a show of hands, a majority of shareholders present in person or by
proxy and voting on the proposal vote in favor of the resolution or (ii) on a poll, a majority of the shares present at the meeting in person or by proxy and voting on the proposal are voted in favor of the
resolution. As a result, abstentions and broker non-votes will have no effect on the vote outcome.

THE BOARD OF DIRECTORS RECOMMENDS A
VOTE FOR PROPOSAL NO. 4.

9

PROPOSAL NO. 5

APPROVAL OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

On February 28, 2014, the Audit Committee of the Board of Directors elected to dismiss Deloitte & Touche LLP
(D&T) as our independent registered public accounting firm in the United States. D&T served as our independent registered accounting firm in the United States and as our auditor in the UK from 2010 to 2013. Also on
February 28, 2014, our Audit Committee approved the engagement of Ernst & Young LLP (EY) as our independent registered public accounting firm in the United States and as our auditor in the UK for the fiscal
year ending December 31, 2014, and our Audit Committee has further directed that we submit the selection of EY as our auditor in the UK for approval by our shareholders at the Annual General Meeting.

The reports of D&T on our consolidated financial statements as of and for the fiscal years ended December 31, 2012 and
December 31, 2013 contained no adverse opinion or disclaimer of opinion and were not qualified or modified as to uncertainty, audit scope or accounting principles. During the fiscal years ended December 31, 2012 and 2013 and any subsequent
interim period preceding the dismissal of D&T as our independent registered public accounting firm, there were no disagreements with D&T on any matter of accounting principles or practices, financial statement disclosure, or auditing scope
or procedure, which disagreements, if not resolved to the satisfaction of D&T, would have caused D&T to make reference to such disagreements in its report on the consolidated financial statements for such years. D&T has provided the
Company with a copy of D&Ts letter addressed to the Securities and Exchange Commission stating that D&T agrees with the disclosures made by the Company in response to Item 304(a) of Regulation S-K, as contained in the
Companys Current Report on Form 8-K filed on February 28, 2014. As required under the Companies Act, the Company has received from D&T a statutory statement of circumstances upon ceasing to hold office as auditor, a copy of which is
available on the Companys website.

The Company has not consulted with EY during the two fiscal years ended December 31, 2013
and 2012, and the subsequent interim period preceding the engagement of EY, regarding (i) the application of accounting principles to a specified transaction either completed or proposed or the type of audit opinion that might be rendered on
our consolidated financial statements; or (ii) any matter that was either the subject of a disagreement, as that term is defined in Item 304(a)(1)(iv) of Regulation S-K and the related instructions to Item 304 of
Regulation S-K, or a reportable event, as described in Item 304(a)(1)(v) of Regulation S-K.

The Audit Committee reviews
and pre-approves all audit and non-audit services performed by its independent registered public accounting firm, as well as the fees charged for such services. All fees incurred in fiscal 2013 for services rendered by D&T were approved in
accordance with these policies. In its review of non-audit service fees, the Audit Committee considers, among other things, the possible impact of the performance of such services on the auditors
independence. The Audit Committee has determined that the non-audit services performed by D&T in the fiscal year ended December 31, 2013 were compatible with maintaining the auditors independence. Additional information concerning the
Audit Committee and its activities can be found in the following sections of this Proxy Statement: Board Committees and Report of the Audit Committee.

EY commenced auditing our annual financial statements with the fiscal year ended December 31, 2014. Representatives of D&T are
expected to be available telephonically at the Annual General Meeting, will have the opportunity to make a statement if they desire to do so and will be available to respond to appropriate shareholder questions.

10

Fees for Independent Registered Public Accounting Firm

The following is a summary of the fees billed to the Company by D&T for professional services rendered for the fiscal years ended
December 31, 2013 and 2012. These fees are for work invoiced in the fiscal years indicated.

2013

2012

Audit Fees (1):

$

737,700

$

608,119

Audit-Related Fees (2):

$

194,041

$

43,862

Tax Fees (3):

$

79,159

$

50,000

All Other Fees (4):

$

90,000

$

101,750

Total All Fees:

$

1,100,900

$

803,731

(1)

Audit fees for 2013 include fees incurred in connection with the audit of financial statements as of December 31, 2013 and December 31, 2012 as prepared in accordance with U.S. generally accepted accounting
principles.

(2)

Audit-related fees consist of costs incurred in connection with the audit of statutory financial statements as of December 31, 2013 and December 31, 2012 as prepared in accordance with International Financial
Reporting Standards.

All other fees consist primarily of costs incurred in connection with registration statement filings and comfort letters issued in connection with financing opportunities.

Shareholders will be asked at the Annual General Meeting to approve the following resolution pursuant to this Proposal No. 5:

RESOLVED, to appoint Ernst & Young LLP as the Companys auditors to hold office from the conclusion of this meeting
until the conclusion of the next meeting at which the annual accounts are laid before the Company and to authorize the directors to agree upon the remuneration of the auditors.

In the event that shareholders do not approve the foregoing resolution, we will need to engage a third-party auditor who will act as our
independent registered public accounting firm under U.S. law and as our statutory auditor under UK law for the fiscal year ending December 31, 2014. We may proceed to engage such firm as our Board and Audit Committee deem advisable,
which firm may include Ernst & Young LLP.

Vote Required

This proposal will be approved if (i) on a show of hands, a majority of shareholders present in person or by proxy and
voting on the proposal vote in favor of the resolution or (ii) on a poll, a majority of the shares present at the meeting in person or by proxy and voting on the proposal are voted in favor of the resolution. As a
result, abstentions and broker non-votes will have no effect on the vote outcome.

THE BOARD OF DIRECTORS RECOMMENDS A VOTE
FOR PROPOSAL NO. 5

11

ADDITIONAL BUSINESS

As a public limited company organized under the laws of England and Wales, it is a statutory requirement that the Board lay before the Annual
General Meeting the Companys statutory accounts, which are the annual report and the accounts for the financial year ended December 31, 2013 prepared in accordance with International Financial Reporting Standards (the
Statutory Accounts). As required by the Companies Act and the Articles of Association of the Company, the Statutory Accounts will be made available for download in PDF format on the Companys website
(http://investor.amarincorp.com) as soon as they are complete, but no later than June 17, 2014, which is twenty-one days in advance of the Annual General Meeting. In addition, hard copies of the Statutory Accounts may be obtained, once
they are complete, by contacting the Companys investor relations department at Amarin Corporation plc, c/o Amarin Pharma, Inc., 1430 Route 206, Bedminster, NJ 07921 or by telephone at (908) 719-1315. Shareholders of the Company will not
be asked to take any action in respect of the Statutory Accounts at the Annual General Meeting but shareholders in attendance will have opportunity to ask questions relating to the Statutory Accounts.

At previous annual general meetings of shareholders, we held advisory (non-binding) votes to approve the directors remuneration report
for the applicable fiscal year. We elected to hold these advisory votes in prior periods because it was consistent with the practices of many other publicly traded companies registered under the Companies Act, notwithstanding that the information
included in the directors remuneration report largely mirrored the information on executive compensation that we are required to include in our proxy statement under U.S. legal requirements. In October 2013, the UK regulations governing
directors remuneration reporting, which apply to companies that are quoted companies for the purposes of the Companies Act, were substantially revised, as a result of which the burden and estimated cost of complying with the
revised regulations increased. As we do not believe we are a quoted company for the purposes of the Companies Act, and given that under U.S. legal requirements we are already required to hold an advisory (non-binding) vote on
executive compensation (the say-on-pay vote), we have elected to no longer include a directors remuneration report in our annual proxy statements.

We know of no other matters to be submitted to a vote of shareholders at the Annual General Meeting. If any other matter is properly brought
before the Annual General Meeting or any adjournment thereof, it is the intention of the persons named in the enclosed proxy to vote the shares they represent in accordance with their judgment. In order for any shareholder to nominate a candidate at
a given annual general meeting, he or she must provide timely written notice to our corporate secretary pursuant to the terms of our Articles of Association, as described below.

12

CORPORATE GOVERNANCE

Director Independence

We believe that
the Company benefits from having a strong and independent Board. For a director to be considered independent, the Board must determine that the director does not have any direct or indirect material relationship with the Company that would affect
his or her exercise of independent judgment. On an annual basis, the Board reviews the independence of all directors under guidelines established by NASDAQ and in light of each directors affiliations with the Company and members of management,
as well as significant holdings of Company securities. This review considers all known relevant facts and circumstances in making an independence determination. Based on this review, the Board has made an affirmative determination that all
directors, other than Messrs. Thero and. Zakrzewski, are independent. It was determined that Mr. Thero lacks independence because of his status as the Companys President and Chief Executive Officer effective January 1, 2014. It
was determined that Mr. Zakrzewski lacks independence because of his prior status as the Companys Chief Executive Officer through December 31, 2013.

Code of Business Conduct and Ethics

We
believe that our Board and its committees, led by a group of strong and independent directors, provide the necessary leadership, wisdom and experience that the Company needs in making sound business decisions. Our Code of Business Conduct and Ethics
helps clarify the operating standards and ethics that we expect of all of our officers, directors and employees in making and implementing those decisions. Waivers of our Code of Business Conduct and Ethics for the benefit of a director or an
executive officer may only be granted by the Board or, if permitted, a committee of the Board, and will be publicly announced promptly in our SEC filings. Waivers of our Code of Business Conduct and Ethics for the benefit of other employees may be
made by our Compliance Officer, the Board or, if permitted, a committee of the Board. In furthering our commitment to these principles, we invite you to review our Code of Business Conduct and Ethics and other corporate governance materials located
on our website at www.amarincorp.com.

Shareholder Communications

Generally, shareholders who have questions or concerns regarding the Company should contact our Investor Relations department at
(908) 719-1315. However, any shareholders who wish to address questions regarding the business or affairs of the Company directly with the Board, or any individual director, should direct his or her questions in writing to the Lead Independent
Director of the Board, Amarin Corporation plc, 2 Pembroke House, Upper Pembroke Street 28-32, Dublin 2 Ireland or c/o Amarin Pharma, Inc., 1430 Route 206, Bedminster, NJ 07921. Upon receipt of any such communications, the correspondence will be
directed to the appropriate person, including individual directors.

13

BOARD OF DIRECTORS AND COMMITTEES

During our 2013 fiscal year, our Board met in person five times, by teleconference one time and acted by written consent five times. Each
director attended at least 75% of the aggregate of the meetings of the Board and meetings of the committees of which he or she was a member in our last fiscal year. During fiscal 2013, our Board had an Audit Committee, a Remuneration Committee and a
Nominating and Corporate Governance Committee. All members of the Audit, Remuneration and Nominating and Corporate Governance Committees are non-employee directors who are deemed independent.

All members of our Board who were directors at the time attended the 2013 Annual General Meeting of Shareholders, either in person or via
telephone, with the exception of Dr. Carl Gordon, who resigned from the Board effective as of such date. Although the Company has no formal policies regarding director attendance at annual general meetings, it encourages directors to attend
annual general meetings and expects that all members of the Board will attend the 2014 Annual General Meeting.

Board Leadership Structure and Risk
Oversight

Dr. Ekman is our Chairman of the Board of Directors. Dr. Ekman is independent and all key committees of the Board
are comprised solely of, and chaired by, independent directors. The Board believes that this structure combined with the Companys established governance guidelines, provides an effective leadership structure for the Company. In addition, to
ensure effective independent oversight of the Company, the Board holds meetings of the independent directors of the Board at every meeting.

The Board has overall responsibility for the oversight of the Companys risk management process, which is designed to support the
achievement of organizational objectives, including strategic objectives, to improve long-term organizational performance and enhance shareholder value. Risk management includes not only understanding
company-specific risks and the steps management implements to manage those risks, but also what level of risk is acceptable and appropriate for the Company. Management is responsible for establishing our business strategy, identifying and assessing
the related risks and implementing appropriate risk management practices. The Board periodically reviews our business strategy and managements assessment of the related risk, and discusses with management the appropriate level of risk for the
Company. The Board also delegates oversight to Board committees to oversee selected elements of risk as set forth below.

As part of the
Boards risk oversight role, our Remuneration Committee reviews and evaluates the risks associated with our compensation programs. Our Remuneration Committee has reviewed our compensation policies as generally applicable to our employees and
believes that our policies do not encourage excessive and unnecessary risk-taking, and that the level of risk that they do encourage is not reasonably likely to have a material adverse effect on Amarin. In making this determination, our Remuneration
Committee considered the following:



the Companys use of different types of compensation vehicles to provide a balance of long and short-term incentives with fixed and variable components;



the granting of equity based awards with time-based vesting and performance-based vesting, both of which encourage participants to look to long-term appreciation in equity values;



the Companys annual bonus determinations for each employee being tied to achievement of company goals, which goals promote long-term value; and



the Companys system of internal control over financial reporting and code of conduct and ethics, which among other things, reduce the likelihood of manipulation of the Companys financial performance to
enhance payments under any of its incentive plans.

14

Board Committees

Audit Committee. The Audit Committee is currently comprised of Mr. van Heek (Chairman), Mr. OSullivan and
Ms. Peterson. The Audit Committee oversees the accounting and financial reporting processes of the Company and the audits of the Companys financial statements. The Audit Committee also assists the Board in overseeing the integrity of the
Companys financial statements, the Companys compliance with legal and regulatory requirements, the external auditors qualifications and independence, the performance of the Companys internal audit function and external
auditors and performs other duties, as set forth in the Audit Committee charter. The Audit Committee charter is available on our website at www.amarincorp.com. The Audit Committee met by teleconference five times during our 2013 fiscal year.
All members of the Audit Committee satisfy the current independence standards promulgated by NASDAQ and the SEC and the Board has determined that Mr. van Heek is an audit committee financial expert, as the SEC has defined that term
in Item 407 of Regulation S-K.

Nominating and Corporate Governance Committee. Currently, the Nominating and Corporate
Governance Committee is comprised of Dr. Ekman (Chairman) and Mr. OSullivan. Effective as of the close of the 2014 Annual General Meeting, Mr. OSullivan will replace Dr. Ekman as Chairman of the Nominating and
Corporate Governance Committee, and Ms. Peterson will become a member of the Nominating and Corporate Governance Committee. The Nominating and Corporate Governance Committee is responsible for identifying individuals qualified to become members
of the Board, consistent with criteria approved by the Board. The Nominating and Corporate Governance Committee also develops and implements policies and processes regarding corporate governance matters, assesses Board membership needs and acts as
the Companys nominating committee by reviewing potential director nominees and recommending nominees to the Board. The Nominating and Corporate Governance Committee charter is available on our website at www.amarincorp.com. The
Nominating and Corporate Governance Committee met by teleconference two times during our 2013 fiscal year. All members of the Nominating and Corporate Governance Committee satisfy the current NASDAQ independence standards.

Remuneration Committee. The Remuneration Committee is currently comprised of Dr. Healy (Chairman), Mr. Stack and Mr. van
Heek. The Remuneration Committee, together with the Board, determines the framework for the compensation of the Companys chief executive officer and chairman and such other members of executive management as it is designated to consider. The
Remuneration Committee also determines the corporate and individual performance goals under the Companys management incentive plan and achievement of these goals, as well as determines the policy for and scope of pension arrangements, service
agreements for the executive management team and termination payments. Further, the Remuneration Committee oversees any major changes in employee benefit structures throughout the Company, reviews and authorizes the reimbursement of any claims for
expenses from the chief executive officer and chairman in excess of £10,000 and performs other duties, as set forth in the Remuneration Committee charter. Additionally, the Remuneration Committee reviews and evaluates the risks associated with
our compensation programs. The Remuneration Committee may delegate its authority to a subcommittee composed of one or more of its members. The Remuneration Committee charter is available on our website at www.amarincorp.com. The Remuneration
Committee met by teleconference six times during our 2013 fiscal year. All members of the Remuneration Committee satisfy the current NASDAQ and SEC independence standards and qualify as outside directors pursuant to the Code.

Compensation Committee Interlocks and Insider Participation

During the last completed fiscal year, no member of the Remuneration Committee was a current or former officer or employee of Amarin. None of
our executive officers served as a member of the compensation committee (or board of directors serving the compensation function) of another entity where such entitys executive officers served on our Remuneration Committee. Moreover, none of
our executive officers served as a member of the compensation committee (or board of directors serving the compensation function) of another entity where such entitys executive officers served on our Board.

15

EXECUTIVE OFFICERS AND CERTAIN SIGNIFICANT EMPLOYEES

Our current executive officers and certain significant employees and their respective positions are set forth in the following table.
Biographical information regarding each executive officer and significant employee is set forth following the table.

John F. Thero joined Amarin in November 2009. He was promoted to President and Chief Executive Officer,
and appointed to the Board, effective January 2014. Prior to his promotion, he was Amarins President since November 2010 before which he was Amarins Chief Financial Officer. Mr. Thero has more than 20 years of senior financial and
operational management experience, including supporting the growth of life science companies for over 15 years. Mr. Thero has helped manage both the successful commercial growth and the successful sale of companies. In 2007, Mr. Thero was
Chief Financial Officer at ViaCell, Inc., where he helped guide the company to its successful sale. From 2003 to 2007, Mr. Thero was Senior Vice President at Acusphere, Inc., where he oversaw the successful build-out and qualification of
manufacturing operations. From 1994 to 2003, in a number of senior positions at Abiomed, Inc., including Senior Vice President Business Operations and Chief Financial Officer, he helped manage the transition from a development-stage company into a
commercial entity. Mr. Thero began his professional career at Arthur Andersen LLP, during which time he became a Certified Public Accountant.

Joseph T. Kennedy joined Amarin in December 2011 as General Counsel and was named Amarins Secretary and Chief Compliance Officer
in February 2012. From March 2009 to December 2011, he was Vice President, General Counsel and Secretary of Transcept Pharmaceuticals, Inc., where he played a lead role negotiating the companys strategic collaboration with Purdue Pharma,
helped secure key U.S. patents, helped obtain FDA approval for the companys lead product and had responsibility for all legal and compliance matters affecting the company. Mr. Kennedy represented large pharmaceutical companies, developing
life science companies and venture capital firms in private law practice from January 2006 to March 2009. Prior to that, Mr. Kennedy served as Chief Corporate Counsel, then Vice President, Acting Chief Legal Officer with Eyetech
Pharmaceuticals, Inc. His work at Eyetech included transitioning the company from private to public, legal matters related to the companys development and commercialization collaboration with Pfizer Inc., public company and pharmaceutical
industry compliance, and the sale of the company to OSI Pharmaceuticals Inc. Previously, Mr. Kennedy served as Vice President and U.S. Counsel, Corporate Business Development, with Élan Corporation, plc where he helped acquire
technologies, managed legal issues related to multiple collaborations and participated in the companys sale of assets that raised over $2.0 billion in a restructuring.

Steven B. Ketchum, Ph.D., joined Amarin in February 2012 as President of Research and Development, Senior Vice President.
Dr. Ketchum has 20 years of experience in late-stage product development and clinical regulatory strategy. From 2008 to 2012, Dr. Ketchum served as Senior Vice President of Research and Development for Sunesis Pharmaceuticals where he
provided strategic direction for all facets of research and development, including clinical strategy and operations, regulatory affairs, and pharmaceutical development. From 2005 to 2008, Dr. Ketchum served as Senior Vice President of
Research and Development and Medical Affairs for Reliant Pharmaceuticals where he led development and support activities for Lovaza and other commercialized cardiovascular products. Prior to 2005, Dr. Ketchum was SVP of Operations and

16

Regulatory Affairs at IntraBiotics Pharmaceuticals, and also held positions of increasing responsibility in regulatory affairs during his nearly eight-year tenure at ALZA Corporation, where he
supported the development and commercialization of a number of products, including Concerta. Dr. Ketchum earned a Ph.D. in pharmacology from University College London and a B.S. in biological sciences from Stanford University.

Michael J. Farrell joined Amarin in July 2013 as Controller and was named Amarins principal accounting officer and principal
financial officer in January 2014. Prior to joining Amarin, Mr. Farrell spent the previous ten years with various life sciences companies. From May 2012 to June 2013, Mr. Farrell was the Controller for Unigene Laboratories, Inc., a
publicly traded biotechnology company, where he was responsible for the accounting and finance function, which included a significant role in multiple financing transactions. From October 2010 to April 2012, he was the Controller of New American
Therapeutics, Inc., where he contributed to the formation of the company and the successful acquisition and subsequent divestiture of the companys assets. From April 2008 to September 2010, he was Controller of Akrimax Pharmaceuticals LLC.
From April 2004 through March 2008, he held various roles of increasing responsibility within the finance department at Reliant Pharmaceuticals, Inc. prior to the sale of the company to GlaxoSmithKline. Mr. Farrell started his career at Arthur
Andersen LLP in 1999, during which time he became a Certified Public Accountant. Mr. Farrell holds a B.S. in Accounting from the University of Maryland.

Aaron D. Berg joined Amarin in November 2012 as Vice President, Marketing and Managed Care, and was named Senior Vice President,
Marketing and Sales in February 2014. Before joining Amarin, Mr. Berg was the President and Chief Executive Officer of Essentialis, Inc. from 2009 to 2012, where he led the companys work on triglyceride management. Prior to joining
Essentialis, Mr. Berg was Vice President of Marketing and Sales at Kos Pharmaceuticals for six years, where he contributed to the acquisition of Kos by Abbott Laboratories. Prior to his position with Kos Pharmaceuticals, Mr. Berg began his
pharmaceutical industry career as a sales representative with Bristol-Myers Squibb, followed by various positions with Schering-Plough and GlaxoSmithKline.

17

CERTAIN RELATIONSHIPS AND RELATED-PARTY TRANSACTIONS

Transactions with Related Parties

Other
than compensation arrangements described below under the captions Executive Compensation and Director Compensation, we are not a party to any transactions between us and certain related parties, which are
generally considered to be our directors and executive officers, nominees for director, holders of 5% or more of our outstanding Shares and members of their immediate families.

Related-Party Transaction Review and Approval

Our Board has adopted policies and procedures for the review and approval of related-party transactions and has delegated to our Compliance
Officer the authority to review and approve the material terms of any proposed related-party transactions.

Pursuant to our Code of
Business Conduct and Ethics, any transaction or relationship that reasonably could be expected to give rise to a conflict of interest should be promptly reported to the Compliance Officer. Our Compliance Officer may notify the Board or a committee
thereof as deemed appropriate. Conflicts of interest may arise in the following situations: if an individual is simultaneously employed or engaged by Amarin and another business (particularly a client or business partner of Amarin); if an individual
participates in any activity that enhances or supports a competitors position; if an individual or member of such persons immediate family accepts a gift with the intent to improperly influence the normal business relationship between
Amarin and its clients or business partners or gives to or accepts gifts from a competitor; if an individual or a member of such persons immediate family holds a financial interest in another business (particularly a client or business partner
of Amarin); and if an individual conducts business on behalf of Amarin with a business in which a family member of such individual is associated in any significant role.

EQUITY COMPENSATION PLAN INFORMATION

The following table sets forth certain information, as of December 31, 2013, regarding stock options previously issued by the Company as
compensation for services pursuant to the Amarin Corporation plc 2011 Stock Incentive Plan and the Amarin Corporation plc 2002 Stock Option Plan:

Consists of 600,000 Ordinary Shares which are issuable upon exercise of stock options outside of the Amarin Corporation plc 2011 Stock Incentive Plan granted to each of Joseph T. Kennedy and Stephen B. Ketchum as an
employment inducement award in connection with the commencement of Mr. Kennedys and Dr. Ketchums employment with Amarin as Senior Vice President, General Counsel and President of Research and Development, Senior Vice President,
respectively. These grants were made in reliance on NASDAQ Listing Rule 5635(c)(4). These shares were registered on a Registration Statement on Form S-8 filed with the SEC on March 16, 2012.

18

SECTION 16(A) BENEFICIAL OWNERSHIP REPORTING COMPLIANCE

Section 16(a) of the Exchange Act requires our executive officers and directors, and persons who own more than 10% of a registered class
of our equity securities, to file reports of beneficial ownership and changes in beneficial ownership with the SEC. Executive officers, directors and greater-than-10% shareholders are required by SEC regulations to furnish us with copies of all
reports filed under Section 16(a). To the Companys knowledge, based solely on the review of copies of the reports filed with the SEC, all reports required to be filed by our executive officers, directors and greater-than-10% shareholders
during the fiscal year ended December 31, 2013 were timely filed.

INSIDER TRADING POLICY

Amarin has an insider trading policy that applies to all officers, directors and employees and certain affiliated persons. Amarins
insider trading policy prohibits sale of any Amarin securities that are not owned by such persons at the time of the sale, so called short sales. Those persons subject to Amarins insider trading policy may not pledge Amarins securities
as collateral for a loan (or modify an existing pledge) unless the pledge has been approved by the Audit Committee of the Board of Directors.

19

SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT

Based on information available to us and filings with the SEC, the following table sets forth certain information regarding the beneficial
ownership (as defined by Rule 13d-3 under the Securities Exchange Act of 1934) of our outstanding Shares for (i) each of our directors, (ii) each of our named executive officers, as defined in Executive Compensation
below, (iii) all of our directors and executive officers as a group, and (iv) persons known to us to beneficially hold more than 5% of our outstanding Shares. The following information is presented as of March 15, 2014.

Beneficial ownership and percentage ownership are determined in accordance with the rules of the SEC and include voting or investment power
with respect to our Shares. This information does not necessarily indicate beneficial ownership for any other purpose. Under these rules, Shares issuable under stock options or warrants that are exercisable within 60 days of March 15, 2014
are deemed outstanding for the purpose of computing the percentage ownership of the person holding the options or warrant(s), but are not deemed outstanding for the purpose of computing the percentage ownership of any other person.

Unless otherwise indicated and subject to applicable community property laws, to our knowledge, each shareholder named in the following table
possesses sole voting and investment power over their Shares, except for those jointly owned with that persons spouse. Unless otherwise indicated below, the address of each person listed on the table is c/o Amarin Pharma, Inc., 1430 Route
206, Bedminster, NJ 07921.

Shares BeneficiallyOwned

Name and Address of Beneficial Owner

Number(1)

Percent ofClass(2)

Greater than 5% Holders:

Camber Capital Management LLC(3)

101 Huntington Avenue

Suite 2550

Boston, MA 02199

10,300,000

5.96

Current directors and named executive officers:

John F. Thero(4)

1,336,682

0.77

Lars G. Ekman(5)

175,000

0.10

James I. Healy(6)

6,471,588

3.74

Kristine Peterson(7)

120,000

0.07

Jan van Heek(8)

130,203

0.08

Patrick J. OSullivan(9)

60,000

0.03

David Stack(10)

15,000

0.01

Joseph S. Zakrzewski(11)

2,330,214

1.35

Joseph T. Kennedy(12)

427,181

0.25

Steven B. Ketchum(13)

353,125

0.20

All current directors and executive officers as a group (11 persons)

11,423,155

6.61

(1)

Represents Shares held as of March 15, 2014, plus Shares that may be acquired upon exercise of options and warrants exercisable within 60 days of March 15, 2014.

(2)

Based on 172,885,984 Ordinary Shares outstanding as of March 15, 2014. The percentage ownership and voting power for each person (or all directors and executive officers as a group) is calculated by assuming the
exercise or conversion of all options and warrants exercisable within 60 days of March 15, 2014 held by such person and the non-exercise and non-conversion of all outstanding options and warrants held by all other persons.

(3)

Based on a Schedule 13G filed January 31, 2014, filed jointly on behalf of Camber Capital Management LLC and Stephen Dubois, who share voting power and dispositive power over the Shares.

20

(4)

Based on a Form 4 filed January 10, 2014, a Form 4 filed November 20, 2013, a Form 4 filed January 30, 2013, a Form 4 filed January 2, 2012, a Form 4 filed September 24, 2012, a Form 4 filed
July 30, 2012, Form 4 filed April 10, 2012, a Form 4 filed February 1, 2012 and a Form 3 filed December 30, 2011. Includes 64,900 Shares and 1,273,549 Shares issuable upon the exercise of options exercisable within 60 days of
March 15, 2014.

(5)

Based on a Form 4 filed November 20, 2013, a Form 4 filed July 12, 2012 and a Form 3 filed December 30, 2010. Includes 135,000 Shares issuable upon the exercise of options exercisable within 60 days of
March 15, 2014.

(6)

Based on a Form 4 filed September 5, 2012, a Form 4 filed August 15, 2012, a Form 4 filed July 13, 2012, a Form 4 filed April 6, 2012, a Form 4 filed April 4, 2012, a Form 4 filed
January 31, 2012 and a Schedule 13D/A on behalf of Sofinnova Venture Partners VII L.P. Includes 6,321,588 Shares owned directly by Sofinnova Venture Partners VII L.P., 90,000 Shares directly owned by Dr. Healy and 60,000 shares issuable
upon the exercise of options exercisable within 60 days of March 15, 2014 directly owned by Dr. Healy. Dr. Healy may be deemed to have shared voting and dispositive power over the Shares owned by Sofinnova Venture Partners VII L.P.
via Sofinnova Management VII, LLC (the general partner of Sofinnova Venture Partners), of which he is a managing general partner, but Dr. Healy disclaims beneficial ownership of the Shares except to the extent of his pecuniary interest in
Sofinnova Management VII, LLC.

(7)

Based on a Form 4 filed July 12, 2012 and a Form 3 filed December 30, 2010. Includes 120,000 Shares issuable upon the exercise of options exercisable within 60 days of March 15, 2014.

(8)

Based on a Form 4 filed July 11, 2013, a Form 4 filed January 14, 2013, a Form 4 filed July 12, 2012 and a Form 4 filed April 12, 2012. Includes 22,119 Shares and 105,000 Shares issuable upon the
exercise of options exercisable within 60 days of March 15, 2014.

(9)

Based on a Form 4 filed July 12, 2012, a Form 4 filed December 14, 2011 and a Form 3 filed December 15, 2011. Includes 66,250 Shares issuable upon the exercise of options exercisable within 60 days of
March 15, 2014.

(10)

Based on a Form 3 filed December 12, 2012 and Form 4 filed December 12, 2012. Includes 15,000 Shares issuable upon the exercise of options exercisable within 60 days of March 15, 2014.

(11)

Based on a Form 4 filed November 18, 2014, a Form 4 filed January 2, 2013, a Form 4 filed October 3, 2012, a Form 4 filed July 30, 2012, a Form 4 filed February 1, 2012, a Form 4 filed
October 20, 2011, and a Form 4 filed April 19, 2011. Includes 226,047 Shares and 2,104,167 Shares issuable upon the exercise of options exercisable within 60 days of March 15, 2014.

(12)

Based on a Form 4 filed January 10, 2014, a Form 4 filed January 2, 2013, a Form 4 filed July 30, 2012, a Form 4 filed February 3, 2012, a Form 4 filed February December 20, 2011 and a Form 3
filed December 20, 2011. Includes 13,900 Shares and 397,656 Shares issuable upon the exercise of options exercisable within 60 days of March 15, 2014.

(13)

Based on a Form 4 filed January 10, 2014, a Form 4 filed January 2, 2013, a Form 4 filed March 5, 2012, and a Form 3 filed February 21, 2012. Includes 353,125 Shares issuable upon the exercise of
options exercisable within 60 days of March 15, 2014.

21

EXECUTIVE COMPENSATION

Compensation Discussion and Analysis

The
following compensation discussion and analysis describes the material elements of compensation earned in fiscal 2013 by each of the executive officers identified below in the Summary Compensation Table, who are referred to collectively as our
named executive officers. Our named executive officers include our (i) principal executive officer; (ii) principal financial officer; and (iii) the only other executive officers other than the principal executive officer
and the principal financial officer who were serving as executive officers as of December 31, 2013. For the fiscal year ended December 31, 2013, our named executive officers were:

During 2013, we achieved significant commercial, clinical development, intellectual property, supply and other milestones. While these
achievements were important, during 2013, we also experienced a significant and surprising set-back in not obtaining an expanded FDA-approved indication for Vascepa in our proposed ANCHOR indication and experiencing slower than expected revenue
growth resulting in a decline in share price. As discussed more fully below, achievement and setbacks in these objectives were considered by our Remuneration Committee in determining executive compensation for 2013. Important 2013 performance
considerations include:

Secured managed care coverage for over 200 million lives on formulary, including contracting over 100 million Tier 2 covered lives



Reported $26.4 million in revenues which while comparing well to many other drug launches in 2013 was lower than planned

Product Development:



Achieved cumulative patient enrollment in the REDUCE-IT cardiovascular outcomes study of more than 6,500 patients



Established feasibility of fixed-dose statin combination product



Special Protocol Assessment (SPA) agreement for ANCHOR trial rescinded by FDA and appeal process commenced; no action taken by FDA regarding sNDA for the ANCHOR indication

Intellectual Property:



38 patents through December 31, 2013 (40 currently) issued or allowed by U.S. Patent and Trademark Office with numerous additional patent applications being prosecuted in the United States and other countries

Our philosophy in setting compensation policies for executive officers has two fundamental objectives: (1) to attract and retain a highly
skilled team of executives and (2) to align our executives interests with those of our shareholders by rewarding short-term and long-term performance and tying compensation to increases in shareholder value. The Remuneration Committee
believes that executive compensation should be directly linked both to continuous improvements in corporate performance (pay for performance) and accomplishments that are expected to increase shareholder value. In furtherance of this
goal, the Remuneration Committee has adhered to the following guidelines as a foundation for decisions that affect the levels of compensation:



provide a competitive total compensation package that enables the Company to attract and retain highly qualified executives with the skills and experience required for the achievement of business goals;



align compensation elements with the Companys annual goals and long-term business strategies and objectives;



promote the achievement of key strategic and financial performance measures by linking short-term and long-term cash and equity incentives to the achievement of measurable corporate and individual performance
goals; and



align executives incentives with the creation of shareholder value.

The Remuneration
Committee has historically compensated executive officers with three compensation components: base salary, annual incentive bonus and equity-based compensation. The Remuneration Committee believes that cash compensation in the form of base salary
and an annual incentive bonus provides our executives with short-term rewards for success in operations, and that long-term compensation through the award of equity awards aligns the objectives of management with those of our shareholders with
respect to long-term performance and success.

Roles in Determining Compensation

Remuneration Committee

The Remuneration
Committee, together with the Board, determines the framework for the compensation of the Companys executive officers. The Remuneration Committee also determines the corporate and individual performance goals under the Companys management
incentive plan and achievement of these goals, as well as determines the policy for and scope of service agreements for the executive officers and termination payments. While the Remuneration Committee draws on a number of resources, including input
from the Chief Executive Officer and independent compensation consultants, to make decisions regarding the Companys executive compensation program, ultimate decision-making authority rests with the Remuneration Committee, subject in key cases
to ratification by the Board of Directors. The Remuneration Committee relies upon the judgment of its members in making compensation decisions, after reviewing the performance of the Company and evaluating an executives performance during the
year against established goals, operational performance and business responsibilities. In addition, the Remuneration Committee incorporates judgment in the assessment process to respond to and adjust for the evolving business environment.

policies as generally applicable to our employees and believes that our policies do not encourage excessive and unnecessary risk-taking, and that the level of risk that they do encourage is not
reasonably likely to have a material adverse effect on Amarin. In making this determination, our Remuneration Committee considered the following:



the Companys use of different types of compensation vehicles to provide a balance of long and short-term incentives with fixed and variable components;



the granting of equity based awards with time-based vesting and performance-based vesting, both of which encourage participants to look to long-term appreciation in equity values;



the Companys annual bonus determinations for each employee being tied to achievement of company goals, which goals promote long-term value; and



the Companys system of internal control over financial reporting and code of conduct and ethics, which among other things, reduce the likelihood of manipulation of the Companys financial performance to
enhance payments under any of its incentive plans.

Compensation Consultant

The Remuneration Committee retains the services of Radford, a division of AON, as external compensation consultants. The mandate of the
consultants include assisting the Remuneration Committee in its review of executive and director compensation practices, including the competitiveness of pay levels, executive compensation design and benchmarking with the Companys peers in the
industry. The Remuneration Committee regularly evaluates the performance of its compensation consultants, considers alternative compensation consultants and has the final authority to engage and terminate such services.

The Remuneration Committee has assessed the independence of Radford pursuant to SEC rules and concluded that no conflict of interest exists
that would prevent Radford from serving as an independent consultant to the Remuneration Committee.

Chief Executive Officer

Our Chief Executive Officer attends Remuneration Committee meetings and works with the Remuneration Committee Chairman and its compensation
consultants to develop compensation recommendations for the executive officers (excluding the Chief Executive Officer), based upon individual experience and breadth of knowledge, internal considerations, individual performance during the fiscal year
and other factors deemed relevant by the Remuneration Committee. The recommendations are then submitted to the Remuneration Committee for review and consideration. The Remuneration Committee works directly with its compensation consultants to
determine compensation actions for the Chief Executive Officer. In accordance with NASDAQ listing rules, our Chief Executive Officer is not present during voting or deliberations concerning his own compensation.

Competitive Market Benchmarking

The Remuneration Committee draws on a number of resources to assist in the evaluation of the various components of the Companys executive
compensation program. While we do not establish compensation levels based solely on benchmarking, pay practices at other companies are a factor that the Remuneration Committee considers in assessing the reasonableness of compensation and ensuring
that our compensation practices are competitive in the marketplace.

Our peer companies used in determining compensation actions in the
2013 fiscal year were selected by the Remuneration Committee with the support of Radford, a division of AON, which in 2011 was retained to conduct a comprehensive review of the Companys executive compensation practices.

24

In October 2012, our Remuneration Committee updated the list of peer companies which was used in
determining compensation actions in the 2013 fiscal year to consist of 24 publicly-traded companies in the pharmaceutical and biotechnology industries. Radford reviewed the 2011 group of peer companies, which were selected on the basis of their
similarity to us in terms of competition for talent, phase of products in development, financial attributes, research and development expenditures, and stock price, and considered whether to remove such companies from the list of peer companies due
to M&A activity, change in financial profile and change in business focus.

Additionally, Radford considered new additions to the list
of peer companies by identifying publicly-traded, US-based companies based on criteria tied to Amarins projected headcount, revenue and market value for the 2013 fiscal year, refining the list of potential additions to those companies with
between approximately one-third (1/3) to three (3) times Amarins projected headcount, revenue and market value, respectively, for the 2013 fiscal year. Radford also qualitatively evaluated each company based on business focus and
corporate strategy.

The Remuneration Committee considered the foregoing analysis in selecting the following 24 publicly-traded peer
companies for use in determining compensation actions in the 2013 fiscal year:

Acorda Therapeutics, Inc.

ImmunoGen, Inc.

Nektar Therapeutics

Affymax, Inc.

Incyte Corporation

NPS Pharmaceuticals, Inc.

Akorn, Inc.

InterMune, Inc.

Optimer Pharmaceuticals, Inc.

Arena Pharmaceuticals, Inc.

Ironwood Pharmaceuticals, Inc.

Questcor Pharmaceuticals

Ariad Pharmaceuticals, Inc.

Isis Pharmaceuticals, Inc.

Seattle Genetics, Inc.

Auxilium Pharmaceuticals, Inc.

Jazz Pharmaceuticals plc

Spectrum Pharmaceuticals, Inc.

AVEO Pharmaceuticals, Inc.

Medivation, Inc.

Theravance, Inc.

Halozyme Therapeutics, Inc.

Momenta Pharmaceuticals, Inc.

VIVUS, Inc.

In addition to the peer group above, the Remuneration Committee also reviews competitive compensation data
from the Radford Global Life Sciences Compensation Surveys, which in 2012 included 18 of the companies in the peer group, as well as a broader survey of 73 publicly traded biotechnology and pharmaceutical companies with between 100 and 1,200
employees. Radford assessed Amarins 2013 compensation against market pay elements such as base salary, target short-term incentives as a percentage of base salary, target total cash compensation and long-term incentives. Additionally,
Amarins incumbent officers were matched to benchmark positions according to each officers primary responsibilities.

The
Remuneration Committee reviews the Companys list of peer companies periodically to reflect changes in market capitalization, developments at the Company relative to its peer companies and other factors.

Implementation of Objectives

In
fiscal 2013, our executive compensation program consisted of the following forms of compensation, each of which are described below in greater detail:



Base Salary



Annual Bonus Incentive



Special Incentive Bonus Program



Equity Compensation



Employee Benefit Program

25

Base Salary

Overview

Our Remuneration Committee aims
to set executives base salaries, in the aggregate, at levels near the 50th percentile of salaries of executives with similar roles at the Companys peer group. The Remuneration Committee believes it is important to provide adequate fixed
compensation to our executive officers working in a highly volatile and competitive industry. Our Remuneration Committee believes that the 50th percentile for base salaries is the minimum cash compensation level that will allow us to attract
and retain highly skilled executives. The Remuneration Committees choice of this target percentile reflects consideration of our shareholders interests in paying what is necessary to achieve our corporate goals, while conserving cash and
equity as much as practicable. We believe that, given the industry in which we operate and our compensation philosophy and objectives, base salaries at the 50th percentile are generally sufficient to retain our current executives and to hire
new executives when and as required. In determining appropriate base salary levels for a given executive officer, the Remuneration Committee also considers the following factors:



individual performance of the executive, as well as overall performance of the Company, during the prior year;



level of responsibility, including breadth, scope and complexity of the position;



level of experience and expertise of the executive;



internal review of the executives compensation relative to other executives to ensure internal equity; and



executive officer compensation levels at other similar companies to ensure competitiveness.

Salaries for executive officers are determined on an individual basis at the time of hire and are set to be competitive with peer companies in
our industry. Adjustments to base salary are considered annually in light of each executive officers individual performance, the Companys performance and compensation levels at peer companies in our industry, as well as changes in job
responsibilities or promotion. The Chief Executive Officer assists the Remuneration Committee in its annual review of the base salaries of other executive officers based on the foregoing criteria.

Changes in Base Salaries for Fiscal 2013

In November 2012, the Remuneration Committee approved for 2013 a 2.5% salary increase for all employees, including Messrs. Zakrzewski, Thero
and each of the Companys Senior Vice Presidents. This increase was determined to approximate the rate of inflation and to approximate the estimated rate of compensation increase in the Companys peer group. Based upon this review, the
Remuneration Committee concluded that after increases of 2.5%, the base salaries of Messrs. Zakrzewski and Thero and the Senior Vice Presidents approximated the 50th percentile of salaries of executives with similar roles at the Companys peer
group. In October 2013, the Remuneration Committee reviewed the expanded responsibilities of Dr. Ketchum and, after consulting with Radford regarding peer analysis, increased Dr. Ketchums base salary by an additional $25,000 to
reflect his increased responsibilities.

Cash Incentive Awards

The Company also provides executive officers with annual performance-based cash bonuses, which are specifically designed to reward executives
for overall corporate performance as well as individual performance in a given year.

In 2011, the Board of Directors adopted a Management
Incentive Compensation Plan (MICP), under which it is expected that the Remuneration Committee each year will determine corporate and individual performance

26

goals and achievement of these goals for purposes of determining annual performance-based cash bonuses. The MCIP is intended to provide structure and predictability regarding the determination of
performance-based cash bonuses. Specifically, the MICP is intended to:

encourage management to work as a team to achieve the Companys goals;

(iii)

encourage individuals to realize goals that are meaningful to the Company;

(iv)

provide incentives for participants to strive for achievement above and beyond the Company goals; and

(v)

help attract and retain high quality senior management personnel.

The MICP provides that the
bonus potential for our executive officers will be established on an annual basis by the Remuneration Committee. Under the MICP, the actual amount of the bonus paid is calculated using a goals-based formula. In order to be eligible to receive a
bonus, the Company must have achieved at least a specified percentage of the corporate goals for that year. The corporate goals and the relative weighting of the corporate and individual performance goals, as well as the relative weighting for each
individual of individual performance goals are established by the Remuneration Committee on an annual basis, shortly after our Board of Directors has approved our annual operating plan. The Remuneration Committee has determined it appropriate to
have our Chief Executive Officer and Presidents goals match our corporate goals. For all other executive officers, individual goals are determined on annual basis by the Remuneration Committee. Under the MICP, the Remuneration Committee
reserves the right to make subjective assessments of executive performance and to separately reward performance beyond established individual or corporate goals and targets, and to award a smaller or larger bonus than provided for in the MICP, or to
award no bonus.

For fiscal 2013, the bonus potential for our executive officers as a percentage of base salary ranged from 65% for our
CEO, 45% for our President, and 40% for our Senior Vice Presidents. All of the bonus potential for our CEO and President were tied to the 2013 corporate goals. Bonus potential for our other Senior Vice Presidents also included an individual goal
measurement tied to their areas of functional responsibility.

Fiscal 2013 Annual Bonus Incentive

Upon completion of fiscal 2013, the Remuneration Committee assessed the Companys overall performance against the achievement of corporate
and individual performance goals established in 2013.

Set forth below are the corporate goals that were considered by the Remuneration
Committee in assessing overall performance for the 2013 fiscal year, as well as the relative weighting of these goals and the Remuneration Committees assessment of achievement for each goal.

2013 Corporate Goals

Sales, Marketing, and Managed
Care (50%): These goals established target performance for the Company regarding the launch of the ANCHOR indication. The specific goals were as follows:

Public Relations/Investor Relations (5%): These goals established target performance for the Company regarding investor relations
matters. The specific goals were as follows:



Stock price: Achieve performance which exceeds peer group as defined for SEC purposes

In
addition to the above stated goals, the Remuneration Committee also established further stretch goals relating to exceeding the net revenue target per the 2013 Operating Plan. These goals, if achieved in full, were given an incremental 50%
weighting.

In reviewing the above-described corporate goals, the Remuneration Committee determined that the Company failed to achieve an
appropriate threshold of achievement as a result of lower than planned revenues, no approval of the ANCHOR indication and a reduction in the Companys stock price.

Individual Performance-Based Cash Bonus Awards

Joseph S. Zakrzewski, Chairman and Chief Executive Officer, and John F. Thero, President

The cash bonus awards for Joseph S. Zakrzewski, our Chairman and Chief Executive Officer, and John F. Thero, our President, were based entirely
on the Companys achievement of the 2013 Corporate Goals. As a result of not achieving key 2013 Corporate Goals, no bonus was awarded to these officers for 2013.

Implement litigation and regulatory strategy to protect Vascepa exclusivity if NCE is not granted

Strategic Development: 10%



Support executive team and Corporate Development on interactions with potential strategic partners



Support CEO and Finance on capital raising transaction

In reviewing the above-described
individual performance goals, the Remuneration Committee first concluded that Mr. Kennedy had substantially achieved all of his individual goals with respect to SEC Matters, Investor Relations and Compliance, Legal Function Management,
Pharmaceutical Industry Compliance, Intellectual Property and Hatch-Waxman Exclusivity, and Strategic Development, for a cumulative total of 100%. In recognition of Mr. Kennedy achieving all of his personal goals in 2013, including significant
progress in patent prosecution efforts, development strategies for protecting Vascepa exclusivity and contribution to the regulatory appeal strategy for Vascepa, Mr. Kennedy was awarded a bonus of 40% of his 2013 salary.

Steven B. Ketchum, Ph.D., President of Research and Development, Senior Vice President

For Dr. Ketchum, individual performance goals for fiscal 2013 were as follows:

Clinical/Regulatory Affairs: 55%



ANCHOR indication sNDA: Submitted and approved, including advisory committee support



Outcomes study: 50% enrollment and 100% enrollment



Combination with statin: Reported results from first PK study; defined next-step clinical development program and regulatory path to NDA



Pediatric exclusivity: Written request obtained from FDA that would provide an additional six-months exclusivity protection for Vascepa

Alternative supplier: Development strategy defined and pre-IND interaction conducted to complete collaboration objectives in current agreement; CMC and other technical development support provided to facilitate
negotiation of next-step agreement

In reviewing the above-described individual performance goals, the Remuneration Committee first concluded that Dr. Ketchum had partially
achieved each of the goals with respect to Clinical/Regulatory Affairs, Supply, Medical Affairs, CMC, Strategic Matters, and Business Support, for a cumulative total of 66%. After considering this, and as a result of not achieving the minimum 2013
Corporate Goals, the Remuneration Committee determined that no cash bonuses be paid to Dr. Ketchum with respect to 2013 performance.

Special
Incentive Bonus Program

On December 2, 2013, as amended on January 8, 2014, the Remuneration Committee approved a special
incentive bonus program (the Special Bonus Program) for each of Mr. Thero, Dr. Ketchum and Mr. Kennedy. Under the Special Bonus Program, each of these executive officers will be eligible to receive a
one-time, special bonus payment in the amount of: (i) $250,000, in the event the Companys sNDA for the ANCHOR indication is approved by the FDA on or before December 31, 2014; or (ii) $150,000, in the event the FDA approves the
inclusion of the clinical data from the Companys ANCHOR Phase III clinical trial in the Vascepa label for the current (MARINE) indication on or before December 31, 2014; or (iii) $150,000, in the event the Company successfully
secures a declaratory judgment from a court of competent jurisdiction on or before December 31, 2014 confirming the Companys ability to inform physicians of the clinical data from the Companys ANCHOR Phase III clinical trial
notwithstanding an FDA failure to approve the Companys sNDA for the ANCHOR indication by December 31, 2014. All determinations concerning the above referenced criteria for payment will be made by the Company in its sole discretion. To
date, none of the specified criteria have been achieved and as a result, no bonuses have been paid under the Special Bonus Program.

Equity
Compensation

Overview

Stock Options and Restricted Stock Units. As an additional component of our compensation program, executive officers are eligible to
receive equity compensation in the form of stock options and restricted stock units. The Remuneration Committee grants stock options and restricted stock units to executive officers to aid in their retention, to motivate them to assist with the
achievement of both near-term and long-term corporate objectives and to align their interests with those of our shareholders by creating a return tied to the performance of our stock price. In determining the form, date of issuance and value of a
grant, the Remuneration Committee considers the contributions and responsibilities of each executive officer, appropriate incentives for the

30

achievement of our long-term growth, the size and value of grants made to other executives at peer companies holding comparable positions, individual achievement of designated performance goals,
and the Companys overall performance relative to corporate objectives.

We believe that equity awards, through stock options and
restricted stock units, align the objectives of management with those of our shareholders with respect to long-term performance and success. We believe that equity awards serve as useful performance-recognition mechanisms with respect to key
employees, as most awards are subject to time-based vesting provisions. Stock options are typically awarded to executive officers upon their hiring. We believe that such equity awards encourage executive officers to remain with the Company and also
focus on our long-term performance as well as the achievement of specific performance goals.

Equity Award Grant Policy. We have an
equity award grant policy that formalizes our process for granting equity-based awards to officers and employees. Under our equity award grant policy, all grants to executive officers must be approved by our Board of Directors or Remuneration
Committee and all grants to other employees much be granted within guidelines approved by our Board of Directors or Remuneration Committee. All stock options will be awarded at fair market value and calculated based on our closing market price on
the grant date. Under our equity award grant policy, equity awards will generally be granted as follows:



grants made in conjunction with the hiring of a new employee or the promotion of an existing employee will generally be made at meetings of the Remuneration Committee, and effective on the first trading day of the month
following the later of (1) the hire date or the promotion date or (2) the date on which such grant is approved; and



grants made to existing employees other than in connection with a promotion will be made, if at all, on an annual basis and generally shall be made effective on the first trading day of the month following the date on
which such grant is approved.

Equity Grants Awarded in Fiscal 2013

The values of the equity award granted to executive officers for the 2013 fiscal year, as well as all compensation actions taken with respect
to the named executive officers in fiscal 2013, are reflected in the Summary Compensation Table further below.

Employee Benefit Programs

Executive officers are eligible to participate in all of our employee benefit plans, including medical, dental, group life,
disability and accidental death and dismemberment insurance, in each case on the same basis as other employees, subject to applicable law. We also provide vacation and other paid holidays to all employees, including executive officers, all of which
we believe to be comparable to those provided at peer companies. These benefit programs are designed to enable us to attract and retain our workforce in a competitive marketplace. Health, welfare and vacation benefits ensure that we have a
productive and focused workforce through reliable and competitive health and other benefits.

Our retirement savings plan
(401(k) Plan) is a tax-qualified retirement savings plan, pursuant to which all employees, including the named executive officers, are able to contribute certain amounts of their annual compensation, subject to limits prescribed by the
Internal Revenue Service. In 2013 we did not match or supplement contributions to the plan.

We have made lodging available to our
employees to support the travel of our employees to our offices in Connecticut and New Jersey. The purpose of such lodging is to reduce travel costs. Certain of our executives have utilized such company provided lodging from time to time.

31

Tax and Accounting Considerations

Deductibility of Executive Compensation. In making compensation decisions affecting our executive officers, the Remuneration Committee
considers our ability to deduct under applicable federal corporate income tax law compensation payments made to executives. Specifically, the Remuneration Committee considers the requirements and impact of Section 162(m) of the Code, which
limits the tax deductibility to us of compensation in excess of $1.0 million in any year for certain executive officers, except for qualified performance-based compensation under the Section 162(m) rules. The Remuneration
Committee considers the Section 162(m) rules as a factor in determining compensation, but will not necessarily limit compensation to amounts deductible under Section 162(m).

Allocation of Compensation

There
is no pre-established policy or target for the allocation of compensation. The factors described above, as well as the overall compensation philosophy, are reviewed to determine the appropriate level and mix of compensation.

Timing of Compensation Actions

Compensation, including base salary adjustments, for our named executive officers is reviewed annually, usually in the first quarter of the
fiscal year and upon promotion or other change in job responsibilities.

Stock Ownership Guidelines

The Board of Directors believes it is important to align the interests of our executive officers with those of its shareholders. To this end,
in March 2013, the Board of Directors established Stock Ownership Guidelines for its executive officers, including the named executive officers. The guidelines require that each executive officer maintain an equity interest in the Company at least
equal to a multiple of the executive officers base salary, as follows:

Position

Target

Chief Executive Officer

3x annual base salary

Other Executive Officers

1x annual base salary

Equity interests that count toward the satisfaction of the ownership guidelines include the value of Ordinary
Shares owned beneficially owned, the settlement of restricted stock or restricted stock units, and unvested deferred stock units. The calculation of an individuals equity interest, however, does not include the value of stock options (whether
or not vested), unvested restricted stock, and unvested restricted stock units, except unvested deferred stock units. Executive officers have five years from the date of the policy adoption in March 2013 or later commencement of their appointment as
an executive officer to attain these ownership levels. If an executive officer does not meet the applicable guideline by the end of the five-year period, the officer is required to hold a minimum of 50% to 100% of the shares resulting from any
future equity awards until the applicable guideline is met, net of shares sold or withheld to exercise stock options and pay withholding taxes. The Remuneration Committee, however, may make exceptions for any officer on whom this requirement could
impose a financial hardship.

Our compensation policies are designed and are continually being developed to retain and motivate our executive officers and to
reward them for outstanding individual and corporate performance.

32

REMUNERATION COMMITTEE REPORT

The information contained in this report shall not be deemed to be (1) soliciting material, (2) filed
with the SEC, (3) subject to Regulations 14A or 14C of the Exchange Act, or (4) subject to the liabilities of Section 18 of the Exchange Act. This report shall not be deemed incorporated by reference into any of our other filings
under the Exchange Act or the Securities Act of 1933, as amended (the Securities Act), except to the extent that the Company specifically incorporates it by reference into such filing.

The Remuneration Committee of the Board of Directors has reviewed and discussed the Compensation Discussion and Analysis contained in this
Proxy Statement with management. Based on such review and discussion, we have recommended to the Board of Directors that the Compensation Discussion and Analysis be included in this Proxy Statement for the fiscal year ending December 31, 2013.

THE REMUNERATION COMMITTEE

James I. Healy (Chairman)

Jan van Heek

David Stack

33

Summary Compensation Table

The following table sets forth information concerning the compensation of the named executive officers for the fiscal years ended
December 31, 2013, 2012 and 2011.

Mr. Zakrzewski was appointed as our Chief Executive Officer effective November 10, 2010, initially serving on a part-time basis. He became our full-time Chief Executive Officer effective October 20, 2011.
He retired as an officer of the Company effective at the end of the day on December 31, 2013 at which time he also ceased being Chairman. He remains a member of the Companys Board of Directors.

(2)

Bonus summarized in the table consists entirely of discretionary cash bonuses. The bonus paid to Dr. Ketchum was as an incentive for him to join Amarin in February 2012.

(3)

This column reflects the aggregate grant date fair value of restricted stock unit awards granted in 2013 calculated in accordance with FASB ASC 718, excluding the effect of estimated forfeitures. The maximum value of
these restricted stock unit awards for each named executive officer, assuming achievement of all vesting conditions, is as follows: Mr. Zakrzewski: $1,000,350; Mr. Thero: $356,400; Mr. Kennedy: $230,850; and Dr. Ketchum:
$230,850. The vesting of these restricted stock awards was based on the achievement of a minimum product sales threshold in 2013. Since this threshold was not achieved, these awards were all subsequently forfeited.

(4)

This column reflects the aggregate grant date fair value of equity awards granted in 2013, 2012 or 2011 and calculated in accordance with FASB ASC 718, excluding the effect of estimated forfeitures. Assumptions
used in the calculations for these amounts are set forth in note 12 to our consolidated financial statements included in our Annual Report on Form 10-K filed with the SEC on February 27, 2014.

(5)

This column reflects payments under the Management Incentive Compensation Plan in respect of the year earned. See the discussion regarding annual incentive compensation in Compensation Discussion and
Analysis for further information regarding the performance measures.

(6)

Excludes medical, group life insurance and certain other benefits received by the named executive officers that are available generally to all of our salaried employees and certain prerequisites and other personal
benefits received by the named executive officers which do not exceed $10,000 in the aggregate. The amount included for Mr. Kennedy for fiscal 2012 consists entirely of amounts reimbursed to him in connection with relocation-related activities
which Amarin agreed to pay Mr. Kennedy in connection with his joining Amarin.

(7)

Mr. Thero was appointed President and Chief Executive Officer on January 1, 2014.

Narrative
to the Summary Compensation Table

The amounts reported in the Summary Compensation Table, including base salary, stock awards,
option awards, and payments made under the Management Incentive Compensation Plan, are described more fully under Compensation Discussion and Analysis.

34

Grants of Plan-Based Awards

The following table sets forth certain information regarding grants of plan-based option awards to the named executive officers during fiscal
2013:

Name

Grant Date

All Other Option Awards:Number of SecuritiesUnderlying Options (#)

ExercisePrice ofOptionAwards($/Sh)

Grant DateFair ValueofOptionAwards(1)

Joseph S. Zakrzewski

1/2/13

147,500

(2)

$

8.10

$

1,000,050

John F. Thero

1/2/13

52,500

(2)

$

8.10

$

355,950

Joseph T. Kennedy

1/2/13

33,750

(2)

$

8.10

$

228,825

Steven B. Ketchum, Ph.D.

1/2/13

33,750

(3)

$

8.10

$

228,825

(1)

This column reflects the aggregate fair value of equity awards granted in 2013 as of the grant date for each such award, and is calculated in accordance with FASB ASC 718, using the Black-Scholes option-pricing model
and excluding the effect of estimated forfeitures. Assumptions used in the calculations for these amounts are set forth in note 12 to our financial statements included in our Annual Report on Form 10-K filed with the SEC on February 27, 2014.

(2)

The options vest monthly beginning on January 31, 2013.

The following table sets forth
certain information regarding grants of plan-based incentive bonus awards to the named executive officers during fiscal 2013:

Name

Grant Date

Estimated Future Payouts UnderNon-Equity Incentive PlanAwards ($)

Target

Maximum

Joseph S. Zakrzewski



$

366,320

(3)

$

549,480

(3)

12/2/13



(1)



(1)

John F. Thero



$

178,180

(3)

$

267,271

(3)

12/2/13

$

150,000

(2)

$

250,000

(2)

Joseph T. Kennedy



$

143,520

(4)

$

215,280

(4)

12/2/13

$

150,000

(2)

$

250,000

(2)

Steven B. Ketchum, Ph.D.



$

161,900

(3)

$

242,850

(3)

12/2/13

$

150,000

(2)

$

250,000

(2)

(1)

At the request of Mr. Zakrzewski, Mr. Zakrzewski is not eligible to participate in the special incentive bonus program.

(2)

The information in the Target and Maximum columns reflects the range of potential payouts under the special incentive bonus program. To date, none of the specified criteria have been achieved and
as a result, no bonuses have been paid under the special incentive bonus program.

(3)

The information in the Target and Maximum columns reflects the potential payouts under the 2013 annual bonus incentive. As a result of failure to achieve applicable objectives, no bonuses were
paid to these individuals under the 2013 annual bonus incentive.

(4)

Mr. Kennedy was awarded a bonus of $143,520, or 40% of Mr. Kennedys 2013 base salary, under the 2013 annual bonus incentive based on achievement of objectives. Such bonus will be payable on July 1,
2014 assuming Mr. Kennedy remains employed with the Company through June 30, 2014.

35

The following table sets forth certain information regarding grants of plan-based restricted
stock unit awards to the named executive officers during fiscal 2013, which restricted stock unit awards were subsequently forfeited by these officers:

Name

Grant Date

Number of SecuritiesUnderlying RSUs (#)

Grant DateFair ValueofRSUAwards(1)(2)

Joseph S. Zakrzewski

1/2/13

123,500

$

0

John F. Thero

1/2/13

44,000

$

0

Joseph T. Kennedy

1/2/13

28,500

$

0

Steven B. Ketchum, Ph.D.

1/2/13

28,500

$

0

(1)

This column reflects the aggregate grant date fair value of restricted stock unit awards granted in 2013 calculated in accordance with FASB ASC 718, excluding the effect of estimated forfeitures. The maximum value of
these restricted stock unit awards for each named executive officer as of the grant date, assuming achievement of all vesting conditions, is as follows: Mr. Zakrzewski: $1,000,350; Mr. Thero: $356,400; Mr. Kennedy: $230,850; and
Dr. Ketchum: $230,850. As noted in note (2) below, these restricted stock unit awards have been forfeited.

(2)

The vesting of these restricted stock awards was based on the achievement of a minimum product sales threshold in 2013. Since this threshold was not achieved, these awards were all subsequently forfeited.

Option Exercises and Stock Vested

The following table sets forth information about the exercise of stock options by named executive officers in fiscal 2013 to purchase Ordinary
Shares. Such numbers include restricted stock units that vested during fiscal 2013.

Awards

Name

Number of SharesAcquired on Exercise(#)

ValueRealized onExercise($)

Joseph S. Zakrzewski

63,333

320,698

John F. Thero

30,450

172,690

Joseph T. Kennedy

6,950

36,905

Steven B. Ketchum, Ph.D.





36

Outstanding Equity Awards at Fiscal Year-End

The following table shows information regarding outstanding equity awards at December 31, 2013 for our named executive officers.

Option Awards

Number of SecuritiesUnderlying Unexercised Options

OptionExercisePrice($)

OptionExpirationDate

Name

#Exercisable

#Unexercisable

Joseph S. Zakrzewski

35,000



1.35

12/21/2019

1,550,000



3.40

11/11/2020

338,542



9.00

10/20/2021

143,750



(1)

8.86

2/1/2022

36,875



(4)

8.10

1/2/2023

John F. Thero

407,611



1.35

12/21/2019

750,000



3.40

11/11/2020

38,962

44,268

(1)

8.86

2/1/2022

13,125

39,375

(4)

8.10

1/2/2023

Joseph T. Kennedy.

300,000

300,000

(2)

6.35

12/16/2021

29,946

32,554

(1)

8.86

2/1/2022

8,438

25,312

(4)

8.10

1/2/2023

Steven B. Ketchum, Ph.D

275,000

325,000

(3)

8.77

3/1/2022

8,438

25,312

(4)

8.10

1/2/2023

(1)

These stock options vest over 48 months beginning February 29, 2012. Unexercisable options for Mr. Zakrzewski exclude options which were forfeited upon his retirement on December 31, 2013.

(2)

Twenty-five percent (25%) of these stock options vested on December 16, 2012, and the remaining 75% of the options vest ratably over the next 36 months.

(3)

Twenty-five percent (25%) of these stock options vested on February 16, 2013, and the remaining 75% of the options vest ratably over the next 36 months.

(4)

These stock options vest over 48 months beginning January 31, 2013. Unexercisable options for Mr. Zakrzewski exclude options which were forfeited upon his retirement on December 31, 2013.

The following table shows information regarding outstanding restricted stock unit awards at December 31, 2013 for our
named executive officers.

Stock Awards

Number of SecuritiesUnderlying RSUs

MarketValue ofUnvestedRSUs($)

RSUExpirationDate

Name

#Vested

#Unvested (1)

Joseph S. Zakrzewski









John F. Thero



37,800

1.97

05/01/2016

Joseph T. Kennedy.



27,800

1.97

05/01/2016

Steven B. Ketchum, Ph.D.









(1)

One-sixth of each restricted stock unit award vested upon approval of our New Drug Application with the FDA on July 26, 2012 and one-sixth vested
on July 26, 2013. An additional one-sixth will vest upon approval of the Supplemental New Drug Application for the ANCHOR indication for Vascepa, one-sixth will vest upon the one-year anniversary of that date, one-sixth will vest if Vascepa
achieves New Chemical Entity status from the FDA, and the final one-sixth would vest upon the one-year anniversary of that date,

37

provided that, in each case, such vesting occurs prior to May 1, 2016 and subject to the participants continued service to the Company on the vesting date. Unexercisable RSUs for
Mr. Zakrzewski exclude RSUs which he forfeited upon his retirement on December 31, 2013.

Pension Benefits

We do not have a defined benefit plan. Our named executive officers did not participate in, or otherwise receive any special benefits under,
any pension or defined benefit retirement plan sponsored by us during fiscal 2013.

Nonqualified Deferred Compensation

During fiscal 2013, our named executive officers did not contribute to, or earn any amount with respect to, any defined contribution or other
plan sponsored by us that provides for the deferral of compensation on a basis that is not tax-qualified.

Employment, Change of Control and Severance
Arrangements

We have entered into employment agreements with each of our current named executive officers. These agreements set forth
the individuals base salary, bonus compensation, equity compensation and other employee benefits, which are described above in the Compensation Discussion and Analysis.

Joseph S. Zakrzewski

On
December 10, 2013, Mr. Zakrzewski informed the Board of Directors of the Company of his intention to retire as Chief Executive Officer and Chairman of the Board of Directors of the Company. The effective date of his retirement was
December 31, 2013. Mr. Zakrzewski remained on the Board of Directors following his retirement from these positions.

John F.
Thero

As of December 31, 2013, in the event that Mr. Thero had been terminated without cause, he would have been entitled to
severance as follows: continuation of base salary for nine (9) months; continuation of group health plan benefits for up to nine (9) months to the extent authorized by and consistent with 29 U.S.C. § 1161 et seq. (commonly known as
COBRA); and six (6) months of accelerated vesting on all outstanding equity incentive awards to the extent subject to time-based vesting. If Mr. Thero was terminated without cause or he quit for good reason as of
December 31, 2013, in either case, within twenty-four (24) months following a change in control, then he would have been entitled to severance as follows: continuation of base salary for twelve (12) months; continuation of group
health plan benefits for up to twelve (12) months to the extent authorized by and consistent with COBRA; a lump sum cash payment equal to the full target annual performance bonus for the year during which the termination occurred; and 100%
acceleration of vesting on all outstanding equity incentive awards.

Under Mr. Theros amended and restated employment
agreement, entered into between Mr. Thero and Amarin on January 10, 2014, in the event that Mr. Thero is terminated without cause or quits for good reason, he will be entitled to severance as follows: continuation of base salary for
twelve (12) months; continuation of group health plan benefits for up to twelve (12) months to the extent authorized by and consistent with COBRA; and twelve (12) months of accelerated vesting on all outstanding equity incentive
awards to the extent subject to time-based vesting. If Mr. Thero is terminated without cause or he quits for good reason, in either case, within twenty-four (24) months following a change in control, then he will be entitled to severance
as follows: continuation of base salary for eighteen (18) months; continuation of group health plan benefits for up to eighteen (18) months to the extent authorized by and consistent with COBRA; a lump sum cash payment equal to the full
target annual performance bonus for the year during which the termination occurred; and 100% acceleration of vesting on all outstanding equity incentive awards.

38

Joseph T. Kennedy

In the event that Mr. Kennedy is terminated without cause, he will be entitled to severance as follows: continuation of base salary for
six (6) months; continuation of group health plan benefits for up to six (6) months to the extent authorized by and consistent with COBRA; and six (6) months of accelerated vesting on all outstanding equity incentive awards to the
extent subject to time-based vesting. If Mr. Kennedy is terminated without cause or he quits for good reason, in either case, within twenty-four months following a change in control, then he will be entitled to severance as follows:
continuation of base salary for twelve months; continuation of group health plan benefits for up to twelve months to the extent authorized by and consistent with COBRA; a lump sum cash payment equal to the full target annual performance bonus for
the year during which the termination occurred; and 100% acceleration of vesting on all outstanding equity inventive awards.

Stephen
B. Ketchum, Ph.D

In the event that Dr. Ketchum is terminated without cause, he will be entitled to severance as follows:
continuation of base salary for six (6) months; continuation of group health plan benefits for up to six (6) months to the extent authorized by and consistent with COBRA; and six (6) months of accelerated vesting on all outstanding
equity incentive awards to the extent subject to time-based vesting. If Dr. Ketchum is terminated without cause or he quits for good reason, in either case, within twenty-four months following a change in control, then he will be entitled to
severance as follows: continuation of base salary for twelve months; continuation of group health plan benefits for up to twelve months to the extent authorized by and consistent with COBRA; a lump sum cash payment equal to the full target annual
performance bonus for the year during which the termination occurred; and 100% acceleration of vesting on all outstanding equity inventive awards.

Change of Control Provisions in 2002 Stock Option Plan. Under the Companys 2002 Stock Option Plan, in any change of control
transaction (e.g., the acquisition of the Company by way of merger), except as otherwise provided by the Remuneration Committee in the award agreement, (i) all awards held by directors (other than the Chief Executive Officer of the Company)
will automatically vest in full and (ii) all awards held by other participants (i.e., the Chief Executive Officer and participants who are not directors) shall continue to vest following a change of control and, if any such participants
employment is terminated by the Company for any reason other than cause within two years of the change of control, shall become fully exercisable. Any unexercised outstanding awards will then lapse one year following the change of control. The
Remuneration Committee may also elect to accelerate the vesting of any or all outstanding awards at such times and in such amounts as it determines in its sole discretion.

Change of Control Provisions in 2011 Stock Option Plan. Under the Companys 2011 Stock Incentive Plan, in any change of
control transaction (e.g., the acquisition of the Company by way of merger), except as otherwise provided by the Remuneration Committee in the award agreement, (i) all awards held by directors (other than the Chief Executive Officer of the
Company) will automatically vest in full and (ii) all awards held by other participants (i.e., the Chief Executive Officer and participants who are not directors) shall continue to vest following a change of control and, if any such
participants employment is terminated by the Company for any reason other than cause within two years of the change of control, shall become fully exercisable. Any unexercised outstanding awards will then lapse one year following the change of
control. The Remuneration Committee may also elect to accelerate the vesting of any or all outstanding awards at such times and in such amounts as it determines in its sole discretion.

39

Potential Payments upon Termination or Change of Control

The table below shows the benefits potentially payable to each of our named executive officers if a change of control termination occurred on
December 31, 2013, the last business day of fiscal 2013. The closing price per share of our ADSs on The NASDAQ Capital Market on December 31, 2013 was $1.97.

Name

Base Salary($)

BonusPayment($)

AcceleratedVesting ofOptions($)

Continuation ofHealth Benefits($)

Total ($)

Joseph S. Zakrzewski

1,110,000

605,000



36,000

1,741,000

John F. Thero

386,300

154,520



18,000

558,820

Joseph T. Kennedy

368,800

147,520



18,000

534,320

Steven B. Ketchum, Ph.D

381,300

152,520



18,000

551,820

The table below shows the benefits potentially payable to each of our named executive officers if a termination without cause in the absence
of a change of control occurred on December 31, 2013. The closing price per share of our ADSs on The NASDAQ Global Market on December 31, 2013 was $1.97.

Name

Base Salary($)

Bonus Payment($)

AcceleratedVesting ofOptions ($)

Continuationof HealthBenefits ($)

Total ($)

Joseph S. Zakrzewski

550,000

302,500



18,000

870,500

John F. Thero

289,725





13,500

303,225

Joseph T. Kennedy

184,400





9,000

193,400

Steven B. Ketchum, Ph.D.

190,650





9,000

199,650

40

DIRECTOR COMPENSATION

Non-Employee Director Compensation

Upon
recommendation of the Remuneration Committee, the Board of Directors approved an amended non-employee director compensation program effective December 10, 2012, as amended on May 20, 2013 and March 11, 2014. The amended non-employee
director compensation program was intended to approximate the 50th percentile of non-employee director compensation within the Companys peer group. A summary of the non-employee director
compensation arrangements for fiscal 2014 is set forth below.

Retainer andMeeting Fees

Annual Board Retainer Fee:

Non-Executive Chairman

$

95,000

*

All non-employee directors

$

55,000

Annual Chairman Retainer Fees:**

Audit Committee Chairman

$

20,000

Remuneration Committee Chairman

$

15,000

Nominating and Corporate Governance Committee Chairman

$

10,000

Annual Committee Member Retainer Fees:**

Audit Committee

$

10,000

Remuneration Committee

$

7,500

Nominating and Corporate Governance Committee

$

5,000

*

Effective January 1, 2014.

**

These fees are in addition to the Annual Board Retainer Fee, as applicable.

The annual
retainers are paid in equal installments made in arrears within thirty days of the end of each calendar quarter, or upon the earlier resignation or removal of the non-employee director. Amounts owing to non-employee directors as annual retainers
shall be annualized, meaning that for non-employee directors who join the board during the calendar year, such amounts shall be prorated based on the number of calendar days served by such director.

Non-employee directors shall be given an annual election option, which option is to be exercised within ten calendar days of the end of each
quarter, of receiving their annual retainers in the form of either (i) cash or (ii) unregistered non-ADR ordinary shares, with any such issuances to be priced at the greater of (i) the closing price of the Companys ADSs on The
NASDAQ Stock Market on the date which is ten calendar days after the end of each quarter or (ii) £0.50 per share (i.e., par value per Ordinary Share).

In addition, upon their initial appointment or re-election to the Board of Directors, non-employee directors will be eligible to receive
equity awards valued at $135,000 based on a consistently-applied, Black Scholes methodology, split equally in value between option awards and restricted stock units. The restricted stock units are subject to deferred settlement upon the
directors separation of service with the Company) (DSUs) and vest in equal installments over three years on the anniversary of the date of grant . The grant date for such awards will be the date of such initial
appointment or re-election, as the case may be, and the exercise price of any such option award shall be equal to the closing market price on the NASDAQ Stock Market of the Companys ordinary shares (and represented by American Depository
Shares) on the date of such appointment or re-election to the Board of Directors. In addition, for so long as the non-employee director remains on the Board of Directors, the non-employee director will be eligible to receive annual equity awards
valued at $90,000 based on a consistently-applied, Black Scholes methodology, split equally in value between option awards and DSUs. Such award for ordinary shares will vest in full upon the earlier of the one-year anniversary of the date of grant
or the annual general meeting of shareholders in such anniversary year. Such DSUs will vest in equal annual installments over three years, in each case upon the earlier of the anniversary of the date of grant or the annual

41

general meeting of shareholders in such anniversary year. Except with respect to grants made in 2014, the grant date for such awards will be the date of the Companys annual general meeting
of shareholders, and the exercise price of any such option award shall be equal to the closing market price on the NASDAQ Stock Market of the Companys ordinary shares (and represented by American Depository Shares) on the date of such meeting.

Annual equity grants made in 2014 will consist of an option award for 28,500 ordinary shares and 24,000 DSUs. The grant date for such
awards will be March 11, 2014 and the exercise price for such option awards will be equal to the closing market price on the NASDAQ Stock Market of the Companys ordinary shares (and represented by American Depository Shares) on the same
date (the 2014 Exercise Price).

In addition, a Non-Executive Chairman of the Board that continues on the Board
following the Companys annual general meeting of shareholders (and who was not first elected to the Board of Directors at such meeting) will be eligible to receive an annual equity award valued at $20,000 based on a consistently-applied, Black
Scholes methodology, split equally in value between option awards and DSUs. Except with respect to such awards made in 2014, such awards will have a grant date and exercise price identical to other annual equity awards. For 2014, such awards result
in an option award for 6,390 ordinary shares and 5,348 DSUs. In recognition of the current Non-Executive Chairmans service as of January 1, 2014, for 2014, such option award for ordinary shares will have an exercise price equal to the
2014 Exercise Price and will vest in full on January 1, 2015, and such DSU award will have a grant date of March 11, 2014 and vest in equal annual installments over three years commencing on January 1, 2015.

All equity awards will be made pursuant to the terms of the Companys 2011 Stock Incentive Plan, as amended and in effect from time to
time (the Equity Incentive Plan). In the event of a Change of Control (as defined in the Equity Incentive Plan), all option awards and DSUs shall immediately become fully vested.

In addition, the non-employee directors are also eligible to participate in the Companys stock option plans on a case-by-case basis.

Non-employee directors are also reimbursed for their reasonable out-of-pocket expenses incurred in connection with attending Board and
committee meetings.

On July 9, 2013, the Company awarded an option representing the right to purchase 13,500 Ordinary Shares to
each of Dr. Ekman, Dr. Healy, Mr. OSullivan, Ms. Peterson, Mr. Stack and Mr. van Heek in connection with their service on the Board. The total grant-date value of each of these awards was $55,081 based on a
closing price of $5.58 on The NASDAQ Global Market on the date of grant. These awards vest on the one year anniversary of the grant date.

The following table shows the compensation paid in fiscal 2013 to the Companys non-employee directors.

Name

FeesEarned orPaid inCash($)

StockAwards($)

OptionAwards(1)($)

Total ($)

Joseph Anderson

52,025





52,025

Lars G. Ekman

66,151



55,081

121,232

Carl L. Gordon

46,603





46,603

James I. Healy

58,631



55,081

113,712

Patrick J. OSullivan

62,401



55,081

117,482

Kristine Peterson

61,250



55,081

116,331

David Stack

44,931



55,081

100,012

Jan van Heek

47,197

27,553

(2)

55,081

129,831

Joseph S. Zakrzewski(3)









42

(1)

The value of the awards has been computed in accordance with FASB ASC 718, excluding the effect of estimated forfeitures. Assumptions used in the calculations for these amounts are set forth in note 12 to our financial
statements included in our Annual Report on Form 10-K filed with the SEC on February 27, 2014.

(2)

Mr. van Heek received $27,553 of his fees in the form of 4,032 Ordinary Shares.

(3)

Amounts paid to Mr. Zakrzewski in his capacity as Chief Executive Officer and Director are set forth in the Summary Compensation Table above.

In March 2013, our Board of Directors established Stock Ownership Guidelines for its non-employee directors. The guidelines require that each
non-employee director maintain an equity interest in the Company at least equal to three times the amount of such directors annual cash retainer. Equity interests that count toward the satisfaction of the ownership guidelines include the value
of Ordinary Shares owned beneficially, the settlement of restricted stock or restricted stock units, and unvested deferred stock units. The calculation of an individuals equity interest, however, does not include the value of stock options
(whether or not vested), unvested restricted stock, and unvested restricted stock units, except unvested deferred stock units. Non-employee directors have five years from the date of the commencement of their appointment as a director to attain
these ownership levels. If a non-employee director does not meet the applicable guideline by the end of the five-year period, the director is required to hold a minimum of 50% to 100% of the shares resulting from any future equity awards until the
applicable guideline is met, net of shares sold or withheld to exercise stock options and pay withholding taxes. The Remuneration Committee, however, may make exceptions for any director on whom this requirement could impose a financial hardship.

43

REPORT OF THE AUDIT COMMITTEE

The Audit Committee oversees the accounting and financial reporting processes of the Company and the audits of the Companys financial
statements, evaluates auditor performance, manages relations with the Companys independent registered public accounting firm and evaluates policies and procedures relating to internal control systems. The Audit Committee operates under a
written Audit Committee charter that has been adopted by the Board. All members of the Audit Committee currently meet the independence and qualification standards for Audit Committee membership set forth in the listing standards provided by NASDAQ
and the SEC, and the Board has determined that Audit Committee Member Jan van Heek is an audit committee financial expert, as the SEC has defined that term in Item 407 of Regulation S-K.

The Audit Committee members are not professional accountants or auditors. The members functions are not intended to duplicate or to
certify the activities of management and the independent registered public accounting firm. The Audit Committee serves a board-level oversight role in which it provides advice, counsel and direction to management and the auditors on the basis of the
information it receives, discussions with management and the auditors, and the experience of the Audit Committees members in business, financial and accounting matters.

The Audit Committee oversees the Companys financial reporting process on behalf of the Board. The Companys management has the
primary responsibility for the financial statements and reporting process, including the Companys system of internal controls. In fulfilling its oversight responsibilities, the Audit Committee reviewed with management the audited financial
statements included in the Annual Report on Form 10-K for the fiscal year ended December 31, 2013. This review included a discussion of the quality and the acceptability of the Companys financial reporting, including the nature and
extent of disclosures in the financial statements and the accompanying notes. The Audit Committee also reviewed the progress and results of the testing of the design and effectiveness of its internal controls over financial reporting pursuant to
Section 404 of the Sarbanes-Oxley Act of 2002.

The Audit Committee also reviewed with the Companys independent registered
public accounting firm, which is responsible for expressing an opinion on the conformity of the audited financial statements with accounting principles generally accepted in the United States of America, their judgments as to the quality and the
acceptability of the Companys financial reporting and such other matters as are required to be discussed with the Committee by Public Company Accounting Oversight Board (PCAOB) AU380, Communications with Audit
Committees, and SEC Regulation S-X Rule 207, Communication with Audit Committees. The Audit Committee has received the written disclosures and the letter from the independent registered public accounting firm required by the Public
Company Accounting Oversight Board. The Audit Committee discussed with the independent registered public accounting firm their independence from management and the Company, including the matters required by the applicable rules of the Public Company
Accounting Oversight Board.

In addition to the matters specified above, the Audit Committee discussed with the Companys independent
registered public accounting firm the overall scope, plans and estimated costs of their audit. The Committee met with the independent registered public accounting firm periodically, with and without management present, to discuss the results of the
independent registered public accounting firms examinations, the overall quality of the Companys financial reporting and the independent registered public accounting firms reviews of the quarterly financial statements, and drafts
of the quarterly and annual reports.

In reliance on the reviews and discussions referred to above, the Audit Committee recommended to the
Board of Directors that the Companys audited financial statements should be included in the Companys Annual Report on Form 10-K for the fiscal year ended December 31, 2013.

Submitted by the Audit Committee of the Board of Directors

Jan van Heek (Chairman)

Kristine Peterson

Patrick J. OSullivan

44

SHAREHOLDER PROPOSALS

Pursuant to Rule 14a-8 under the Securities and Exchange Act of 1934, as amended, shareholder proposals intended to be included in the 2015
Annual General Meeting proxy materials must be received by the Secretary of the Company no later than January 3, 2015, or otherwise as permitted by applicable law (the Proxy Deadline); provided, however, that if
the 2015 Annual General Meeting date is advanced or delayed by more than 30 days from the anniversary date of the 2014 Annual General Meeting, then shareholders must submit proposals within a reasonable time before the Company begins to print
and send its proxy materials. Proposals received after this timeframe will not be included in the Companys proxy materials for the 2015 Annual General Meeting. The form and substance of these proposals must satisfy the requirements established
by the Companys Articles, the Nominating and Corporate Governance Committee charter and the SEC, and the timing for the submission of any such proposals may be subject to change as a result of changes in SEC rules and regulations.

Under the Companies Act, in order for a shareholder proposal to be presented at an Annual General Meeting, such proposal must have been
requisitioned either by shareholders representing 5% of the voting rights of all members having a right to vote on such proposal at the Annual General Meeting or by at least 100 shareholders who have a right to vote on such proposal at the relevant
Annual General Meeting and who hold shares in the Company on which there has been paid up an average sum, per member, of at least £100. Such proposal must have been signed or otherwise authenticated by all requisitionists and submitted to the
Company not later than (1) six weeks before the Annual General Meeting to which the requests relate, or (2) if later, the time at which notice of that meeting is given by the Company.

Additionally, shareholders who intend to nominate a director to be elected at the 2015 Annual General Meeting must provide the Secretary of
the Company with written notice of such nomination between 7 and 42 days prior to the date of such meeting, together with written notice signed by the director nominee regarding his or her willingness to be elected. Any shareholder seeking to
recommend a director candidate or any director candidate who wishes to be considered by the Nominating and Corporate Governance Committee, the committee that recommends a slate of nominees to the Board for election at each annual general meeting,
must also provide the Secretary of the Company with: the name and address of the shareholder seeking to recommend a director candidate; a representation that the shareholder is a record holder of the Companys securities (or, if the shareholder
is not a record holder, evidence of ownership in accordance with Rule 14a-8(b)(2) of the Exchange Act); the name, age, business and residential address, educational background, current principal occupation or employment for the preceding five full
fiscal years of the proposed director candidate; a description of the qualifications and background of the proposed director candidate, which addresses the minimum qualifications and other criteria for Board membership approved by the Board from
time to time; a description of all arrangements or understandings between the shareholder and the proposed director candidate; the consent of the proposed director candidate to be named in the Proxy Statement relating to the Companys annual
general meeting and to serve as a director if elected at such annual general meeting; and any other information regarding the proposed director candidate that is required to be included in a proxy statement filed pursuant to SEC rules, if then
required. The Nominating and Corporate Governance Committee will consider all director candidates who comply with these requirements and will evaluate these candidates using the criteria described above under the caption, Nomination of
Directors. Director candidates who are then approved by the Board will be included in the Companys proxy statement for that annual general meeting.

45

DELIVERY OF PROXY MATERIALS

Our Annual Report to shareholders for the fiscal year ended December 31, 2013, including audited financial statements, accompanies this
Proxy Statement. Copies of our Annual Report on Form 10-K for the fiscal year ended December 31, 2013 and the exhibits thereto are available from the Company without charge upon written request of a shareholder. Copies of these materials
are also available online through the Securities and Exchange Commission at www.sec.gov. The Company may satisfy SEC rules regarding delivery of proxy materials, including the Proxy Statement and Annual Report, by delivering a single set of
proxy materials to an address shared by two or more Company shareholders. This delivery method can result in meaningful cost savings for the Company. In order to take advantage of this opportunity, the Company may deliver only a single set of proxy
materials to multiple shareholders who share an address, unless contrary instructions are received prior to the mailing date. Similarly, if you share an address with another shareholder and have received multiple copies of our proxy materials, you
may write or call us at the address and phone number below to request delivery of a single copy of the proxy materials in the future. We undertake to deliver promptly upon written or oral request a separate copy of the proxy materials, as requested,
to a shareholder at a shared address to which a single copy of the proxy materials was delivered. If you hold Ordinary Shares as a record shareholder and prefer to receive separate copies of proxy materials either now or in the future, please
contact the Companys investor relations department at Amarin Corporation plc, c/o Amarin Pharma, Inc., 1430 Route 206, Bedminster, NJ 07921 or by telephone at (908) 719-1315. If you hold Ordinary Shares in the form of American Depositary
Shares through Citibank or hold Ordinary Shares through a brokerage firm or bank and you prefer to receive separate copies of proxy materials either now or in the future, please contact Citibank, your brokerage firm or bank, as applicable.

EACH SHAREHOLDER IS URGED TO COMPLETE, DATE, SIGN AND PROMPTLY RETURN THE ENCLOSED PROXY.

46

PROXY FORM

AMARIN CORPORATION PLC

For use at the Annual General Meeting to be held
at The Shelbourne Hotel, 27 St. Stephens Green,

Dublin 2, Ireland at 2:00 p.m. on Monday, 7 July 2014.

I/We

(Name in full block capitals please)

of

being (a) member(s) of Amarin Corporation plc (the Company) hereby appoint the Chairman of the meeting or (see note 6
below)

as my/our proxy to attend, speak and vote for me/us and on my/our behalf as identified by an X in the appropriate box below at the annual general meeting of
the Company to be held at 2:00 p.m. on Monday, 7 July 2014 and at any adjournment of the meeting. This form of proxy relates to the resolutions referred to below.

Ordinary resolution to appoint Ernst & Young LLP as auditors of the Company and to
authorise the audit committee of the board of directors of the Company to fix their remuneration.

Dated this
2014

Signature(s)

Notes:

1.

Please indicate with an X in the appropriate box how you wish the proxy to vote. In the absence of any indication, the proxy will exercise his/her
discretion as to whether and how he/she votes. The proxy may also vote or abstain from voting as he/she thinks fit on any other business which may properly come before the meeting.

2.

If you mark the box abstain, it will mean that your proxy will abstain from voting and, accordingly, your vote will not be counted either for or against the
relevant resolution.

3.

If you mark the box discretionary, the proxy can vote as it chooses or can decide not to vote at all.

4.

The form of proxy should be signed and dated by the member or his attorney duly authorised in writing. If the appointer is a corporation this proxy should be under seal
or under the hand of an officer or attorney duly authorised. Any alteration made to the form of proxy should be initialed.

5.

To be valid, this form of proxy, together with a duly signed and dated power of attorney or any other authority (if any) under which it is executed (or a notarially
certified copy of such power of attorney or other authority) must be signed and dated and lodged at the Companys registrars at the address below, so as to be received by 8:00 a.m. on Friday, 4 July 2014.

6.

A proxy need not be a member of the Company. A member may appoint a proxy of his/her own choice. If you wish to appoint someone else, please delete the words the
Chairman of the meeting and insert the name of the person whom you wish to appoint in the space provided. The Chairman of the meeting will act as your proxy, whether or not such deletion is made, if no other name is inserted. A member may
appoint more than one proxy in relation to the meeting provided that each proxy is appointed to exercise rights attached to different shares.

7.

In the case of joint holders, signature of any one holder will be sufficient, but the names of all the joint holders should be stated. The vote of the senior holder
(according to the order in which the names stand in the register of members in respect of the holding) who tenders a vote in person or by proxy will be accepted to the exclusion of the vote(s) of the other joint holder(s).

8.

Completion and return of a form of proxy will not preclude a member from attending the meeting and voting in person.