"Everyone feels anger, but after the anger it's really hurtful because he's looking down on a whole population of people and he's so misinformed because these places have beautiful people," he told Van Jones on the debut of his CNN program, "The Van Jones Show," which aired Saturday on CNN.

Jay-Z on racism in America

Jay-Z said Trump's comments expose a larger problem of racism in this country and the way that people still talk behind closed doors.

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"There was a moment when Donald Sterling had been exposed as this racist on a private phone conversation that he was having and they took his team from him," Jay-Z said, referring to remarks made in 2014 by the former owner of the Los Angeles Clippers.

"And it's like, OK, that's one way to do it. But another way would have been, let him have his team and then let's talk about it together. ... Maybe some penalties. Because once you do that, all the other closet racists just run back in the hole. You haven't fixed anything. What you've done was spray perfume on a trash can," he said.

Continuing the analogy, he explained that more spray attracts more bugs as you're not actually dealing with the trash -- in this case, racism.

"You don't take the trash out. You keep spraying whatever over it to make it acceptable and then, you know, as those things grow, then you create a superbug. And then now we have Donald Trump, the superbug," he said.

"Donald Trump is a human being, too," he said, adding he was just being funny. "Somewhere along his lineage something happened to him ... and he's in pain and he's expressing it in this sort of way."

"You treat people like human beings. That's the main point," he said. "It goes back to the whole thing -- 'Treat me really bad and pay me well.' It's not going to lead to happiness, it's going to lead to, again, the same thing. Everyone's going to be sick."

Trump fired back at Jay-Z on Twitter early Sunday morning.

"Somebody please inform Jay-Z that because of my policies, Black Unemployment has just been reported to be at the LOWEST RATE EVER RECORDED!" Trump tweeted.

Somebody please inform Jay-Z that because of my policies, Black Unemployment has just been reported to be at the LOWEST RATE EVER RECORDED!

Jay-Z explained that many African-Americans and people in middle America have reflexively voted Democrat for years because their families did, but their needs weren't addressed.

"My problem with government is, I think they forget that it's real people behind these decisions that they're making. ... We're, like, people going through real things in real time and in real pain. And when you ignore that pain for so long, people -- they will act out, and it's like, 'I want to see something different." And that opens the door to what we're living through now."

He added, "Now, politics has become about votes and not about people."

Jay-Z on visiting the White House

Jay-Z was a frequent visitor at the Obama White House but told Van Jones that he doesn't think he'll get invited while Trump is in office.

Jones joked that Trump may surprise him, making a play to be the first "hip-hop president" because he would "get in beefs with people," likes bling and has a plane.