Best of 2012: TVGuide.com Users' Favorite Actors

John Noble, Fringe (tie)

Fringe might not be a ratings juggernaut, but Noble always delivers a powerhouse performance. As the cult hit approaches the series finale, Noble continues to make viewers want more of his character Walter Bishop and his experimental science.
Photo by: Liane Hentscher/FOX

Gary Sinise, CSI: NY (tie)

Sinise's Mac Taylor proved once again this year that you can't keep a good CSI down. After surviving a gunshot, he's more focused than ever on his quest for justice. But he's also taking time to appreciate the other things in life, such as his relationship with Christine. Sinise's combo of stern and soft helped earn him a spot on our users' top 10.… Read moreSinise's Mac Taylor proved once again this year that you can't keep a good CSI down. After surviving a gunshot, he's more focused than ever on his quest for justice. But he's also taking time to appreciate the other things in life, such as his relationship with Christine. Sinise's combo of stern and soft helped earn him a spot on our users' top 10.
Photo by: Cliff Lipson/CBS

Jonny Lee Milller, Elementary

Sherlock's Benedict Cumberbatch casts one long shadow, but Miller's take on Holmes won over viewers with his unique quirk and chemistry with co-star Lucy Liu. Given Miller's charm, it's no mystery at all why this show has become CBS' latest hit.
Photo by: Jojo Whilden/CBS

Patrick Dempsey, Grey's Anatomy

It may have been one of the worst years for Dempsey's Derek Shepherd, but one man's nerve damage is another man's performance gold. Derek's struggles with his career have brought out the best in Dempsey, who perfectly captures his character's inner turmoil. And it seems that our users took notice.
Add to Watchlist: Grey's Anatomy, Patrick Dempsey
Photo by: Danny Feld/ABC

Michael Weatherly, NCIS

Always ready with a one-liner, Weatherly continues to bring a bit of fun to TV's most-watched drama. But this year, Weatherly has shown a little more of DiNozzo's softer side as he opens up more than ever to co-worker Ziva. What's not to love?
Add to Watchlist: Michael Weatherly
Photo by: Monty Brinton/CBS

Jim Parsons, The Big Bang Theory

Bazinga! He might not have taken home another Emmy this year, but Parsons still brought the laughs for our users as the socially inept Sheldon.
Add to Watchlist: Jim Parsons
Photo by: Michael Yarish/Warner Bros.

Mark Harmon, NCIS

Harmon has always been the steely core at the center of this CBS monster hit. This year, his war with Harper Dearing and his unwavering support of his team members only further solidified his place in our users' hearts.
Add to Watchlist: Mark Harmon
Photo by: Michael Yarish/CBS

Nathan Fillion, Castle

Our users can never get enough of Fillion's Castle, but now that he and Beckett are getting hot and heavy, Fillion is really feeling the love. The new relationship has allowed Fillion to play to his goofy, witty — and, of course, ruggedly handsome — strengths.
Add to Watchlist: Nathan Fillion
Photo by: Richard Cartwright/ABC

David Boreanaz, Bones

Whether being abandoned by the woman he loved or fighting to clear her name, Boreanaz's Booth once again proved to be nothing but dedicated to Brennan. Just as Booth stood by Bones, our users are standing by Boreanaz, 2012's favorite TV actor!
Add to Watchlist: David Boreanaz
Photo by: Carin Baer/FOX