Associated products

Specifications

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Applications

Functional Studies

SDS-PAGE

Endotoxin level

< 0.100 Eu/µg

Form

Lyophilised

Additional notes

The ED50, determined by the dose-dependent stimulation of the proliferation of murine CTLL-2 cells, is < 0.5 ng/ml, corresponding to a specific activity of > 2 x 106 units/mg.

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Preparation and Storage

Stability and Storage

Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

n/a

This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

Alternative names

IL 15

IL-15

IL15

IL15_HUMAN

Interleukin 15

Interleukin-15

Interleukin15

MGC9721

see all

Function

Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL-15 requires interaction of IL-15 with components of IL-2R, including IL-2R beta and probably IL-2R gamma but not IL-2R alpha.

Tissue specificity

Most abundant in placenta and skeletal muscle. It is also detected in the heart, lung, liver and kidney. IL15-S21AA is preferentially expressed in tissues such as testis and thymus.

Sequence similarities

Belongs to the IL-15/IL-21 family.

Cellular localization

Secreted and Cytoplasm. Nucleus. IL15-S21AA is not secreted, but rather is stored intracellularly, appearing in the nucleus and cytoplasmic components.