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This tutorial will explain how to fix USB stops working problem in Ubuntu
Note: The success (or otherwise) of the following solution will depend on your hardware and possibly which version of *buntu you are using. Feel free to add your feedback to this thread and alternative solutions

Open a terminal type

gksudo gedit /boot/grub/menu.lst

You will be asked for your password -- don't worry if your password doesn't show, this is normal. Just type in your password as usual, and it will be accepted.

Tried the suggested fix for GRUB2 on Ubuntu 10.04 (Lynx) and, for a moment, believed it had done it. I was able to use the system for longer than I had been until that point. However, my USB mouse’s cursor suddenly froze all over again.

So far, my experience with Lynx has been an unreliable and frustrating one. And I’ve had mostly joy with Ubuntu, since 2005. I hope this gets sorted out soon. One can see on the forums that this is not an isolated issue.

Thank you very very much! After I had spent hours and hours googling around to find out a way to make usb devices work again, I came upon this tutorial. Whatever had I tried, it never worked. Twice fresh install Lucid and Maverick, nothing. I had installed ubuntu on many other machines, no problem at all. And now, on my son’s and my daughter’s laptops – bump! The solution provided in the above tutorial worked like a charm! Great! Thanks!

The solution didn’t work for me (ubuntu 10.10/11.04 beta), but combining this tutorial with another one i found on the web y replaced the
GRUB_CMDLINE_LINUX=”acpi=force irqpoll” line with
GRUB_CMDLINE_LINUX=”pci=nocrs” and worked like a charm after rebooting.
I? not a linux expert so i really don’t know what this does.. perhaps someone can explain it to me.

On my amd64 system, after the update to 11.04 my problems (mouse and keyboard failing after boot) returned. Had previously done the acpi=force to make it work (10.04/10.10).

Just did it again, got me about 60s of running x-windows before the mouse died. Just trying “me’s” suggestion of pci=nocrs. Both settings cause X-windows to take ages to start the window manager. After taking an age to come up- the kb and mouse died before login… Second boot was better so failure is still random (within the first minute). Tried installing mouseemu too to no avail… looking further afield now.

I have never had this issue with any computer I have ever built, but with my new i7 based system, this is definately a problem. Like ayenack mentioned above, I now have a MSI motherboard so maybe the statement is correct. Don’ buy MSI if you plan on running Ubuntu.

I have 3 puters with XP and Ubuntu 11.x installed.
2 Acer laptop’s no problem.
Desktop with a MSI g41m4(ms7592)1.0 board, a 2.7 gig Pentium duel. usb keyboard and use Targus card reader. All puters use many different usb connected devices and no problem. Boinc/seti do have a problem. When I upgraded from 10.04 to 10.10 on another machine, usb was dead in the water. Never did get it fixed. 11.x however worksjust fine.

I have the same problem on my laptop (AMILO L7310GW). With Ubuntu 11.04 (i386), following this guide, i solve the problem (adding “acpi=force irqpoll”).
But now, with Ubuntu 11.10 (i386) it doesn’t work anymore. Any ideas?

Thank you! Works for me on Ubuntu 12.04 but with turning off irqbalance in /etc/default/irqbalance config file (ENABLED=”0″). I have a Microsoft Comfort Curve Keyboard 2000, which is really comfortable for me but its occasional hanging really frazzle me.