In 1616, the Tokugawa shogunate relented, and allowed the clan to have the 10,000 kokuShinano Nakamura Domain. In 1623, Iwaki Yoshitaka was transferred to the newly created 20,000 koku Kameda Domain, a compact holding consisting of 71 villages in Yuki County where his descendants ruled for 13 generations to the Meiji restoration. Relations remained very strong between with the Satake clan, almost to the extent that Kameda Domain became a semi-subsidiary domain of Kubota Domain. This drew unfavorable attention from the Tokugawa shogunate, and in 1718, when Iwaki Hidetaka died, his successor was selected from a branch of the Date clan. Ties between the Iwaki and Date clans strengthened over the next several generations.

The domain had a population of 23,894 people in 4356 households per the 1869 census. The clan maintained its primary residence (kamiyashiki) in Edo at Daidokoro-cho, in Koishikawa.[1]

During the Boshin war, Kameda Domain remained a member of the Ōuetsu Reppan Dōmei; even after Kubota Domain switched sides. Despite its meager military resources, the domain fought against the forces of pro-Imperial Shinjō Domain until an agreement was reached.

The new Meiji government penalized the domain with a reduction in revenues to 18,000 koku. With the abolition of the han system in July 1871, and the absorption of Kameda Domain into Akita Prefecture, the final daimyo of Kameda, Iwaki Takakuni, relocated to Tokyo. In 1884, he and his descendents were granted the title of viscount (shishaku) in the kazoku peerage.