INTENTIONAL PRODUCT USE ISSUE Clinical Trials and Studies

Treatments might be new drugs or new combinations of drugs, new surgical procedures or devices, or new ways to use existing treatments. The goal of clinical trials is to determine if a new test or treatment works and is safe. Clinical trials can also look at other aspects of care, such as improving the quality of life for people with chronic illnesses. People participate in clinical trials for a variety of reasons. Healthy volunteers say they participate to help others and to contribute to moving science forward. Participants with an illness or disease also participate to help others, but also to possibly receive the newest treatment and to have the additional care and attention from the clinical trial staff.

Dermatologic assessment at the patch application site; Investigator assessment of the global response to therapy on a 5-point scale; Patient assessment of pain on a 6-point scale; Plasma concentration of Diclofenac

To explore the effect of Etoricoxib compared to Diclofenac on physical activity in RA subjects with Early morning pain and stiffness.; To explore the effect of Etoricoxib compared to Diclofenac on average daily pain scores, fatigue scores, and quality of life.

Suicide Assessment Scale (differences in scores before and after treatment); Montgomery Asberg Rating Scale (differences in scores before and after treatment); Barratt Impulsiveness Scale (differences in scores before and after treatment); Montgomery Asberg depression Ratin scale (changes in suicidality item before and after treatment); Montgomery Asberg Rating Scale (changes in concentration item before and after treatment); Comprehensive Psychopathological Rating Scale (changes in aggressive feelings item before and after treatment); Comprehensive Psychopthological Rating Scale (changes in fatigue item before and after treatment)

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