Since then, I have worked on mammalian cell biology, in my postdoctoral positions at the European Molecular Biology Laboratory (France) and the Centre for Cancer Biology (AUSTRALIA). This is where I discovered how canonical RNAs are... Read more

Since then, I have worked on mammalian cell biology, in my postdoctoral positions at the European Molecular Biology Laboratory (France) and the Centre for Cancer Biology (AUSTRALIA). This is where I discovered how canonical RNAs are the exception, rather than the rule. Uncovering how an entire class of non-coding RNAs, called circular RNAs, are formed and regulated across cell differentiation lead to a seminal publication in the field. I continue to research how these circular RNAs impact cellular development (ARC Future Fellowship) and cancer (NHMRC-project funding).

My laboratory also has an interest in how inflammation, when allowed to persist chronically, underscores many human ailments including diabetes, arthritis and cancer. We investigate key mediators of this process in breast, lung and blood cancers with particularly poor prognoses so we can use our knowledge to help those who previously have had limited therapeutic options. We know by defining the key molecular players in this process, we can tailor therapies to reduce detrimental side-effects.