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New Interaction Between Soybeans, Valproic Acid Discovered

the MPR take:

Food-drug interactions may have a big impact on patients prescribed drugs with narrow therapeutic indexes. Soy products have been shown to interfere with medications like, levothyroxine replacement, warfarin, and tamoxifen but no research has examined soy and valproic acid (VPA) until now. This study on mice found that soy pretreatment for five days greatly changed the plasma pharmacokinetics of VPA and its metabolite VPA glucuronide (VPAG) via the induction of liver UDP-glucuronosyltransferase (UGT). A decrease in valproic acid bioavailability was also noted.

New Interaction Between Soybeans, Valproic Acid Discovered

The aim of this study was to investigate the effects of soy on the pharmacokinetics and pharmacodynamics of valproic acid (VPA). In a preclinical study, rats were pretreated with two different amounts of soy extract for five days (150 mg/kg and 500 mg/kg), which resulted in decreases of 57% and ...