March Madness—'Mad Money' style!

As many people around the country will spend time putting together their March Madness brackets this week to bet on who will take the win for the NCAA basketball tournament, Jim Cramer has taken bracketology to a whole new level.

"In a perfect world, people would spend the same amount of effort picking and analyzing their own stocks, which is why every year I try to equate the March Madness with your portfolio," said the "Mad Money" host.

In the spirit of profiting both off of March Madness and your portfolio, Cramer both his top stock picks and top players for each region of the NCAA.

South

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Aaron Harrison #2 of the Kentucky Wildcats goes to the basket as Ryan Boatright #11 of the Connecticut Huskies defends during the NCAA Men's Final Four Championship at AT&T Stadium on April 7, 2014 in Arlington, Texas.

Starting with the NCAA southern region, the top two seeds are Duke and Gonzaga University.

In Cramer's opinion Duke is a lot like Disney, with both representing amazing branding with a fabulous head coach.

"I mean, this stock got downgraded today, big splash, and it went up anyways—that's almost home-court advantage," Cramer added.

Duke's head coach, Mike Krzyzewski, just became the very first coach to have 1,000 wins under his belt. Likewise, that record reminds Cramer of Disney CEO Bob Iger, who has tripled his firm's stock value since he took over some 10 years ago.

Then there is the second-seed pick in the southern region, Gonzaga University in Spokane, Washington. Of course, Cramer immediately thought of Boeing, a strong company with top leadership and roots in Washington.

"Gonzaga has become a blue chip name in college basketball, with 15 consecutive NCAA appearances, and in the same way, Boeing is absolutely a must-own stock," Cramer said.

Lately, both Boeing and Gonzaga have been on fire. In 2013 Gonzaga was the No. 1 seed, and this year it's No. 2 for the second time. Boeing has shown the same strength, with its stock doubling since 2012. Cramer thinks Boeing has room to fly even higher with the low price of oil, too.

East

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Ryan Arcidiacono #15 of the Villanova Wildcats dribbles the ball during the Progressive Legends Classic college basketball game against the Virginia Commonwealth Rams at the Barclays Center on November 24, 2014 in the Brooklyn borough of New York City.

The top dog of the East for Cramer is the Villanova Wildcats. The secret to the teams' success thus far is its balance, which in many ways reminds him of 3M. This company makes boatloads of products, yet somehow has an impressive ability to balance them across many divisions.

Additionally, both Villanova and 3M are very consistent. Villanova has a combined record of 61 wins and only seven losses, and 3M has never strayed from its expected earnings per shares by more than 1.5 percent.

The second seed of the East is the University of Virginia Cavaliers, which reminds Cramer of Virginia-based Orbital ATK. Both UVA and Orbital have recently appeared back on to the scene after several years of being irrelevant.

"At the end of the day this is a team that's 29 and 3, and none of those three losses were by more than six points. By the same token, Orbital ATK doesn't get enough credit from Wall Street," said the "Mad Money" host.

Midwest

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Andrew Harrison #5 of the Kentucky Wildcats shoots against the Auburn Tigers, March 14, 2015.

The No. 1 seed is the University of Kentucky Wildcats, an overwhelming favorite for the whole tournament. If Kentucky ends up sweeping the tournament, it will be the first team to finish the season undefeated since Indiana in 1976.

Likewise, Cramer compared Kentucky to monster powerhouse Apple. This is perhaps one of the most dominant companies on the planet with a massive market cap. And just like Kentucky, it has an amazing head coach: Tim Cook.

"It hasn't let you down yet, and I think its run is far from finished, just like—I hate to say it because I didn't pick them—Kentucky's likely to cruise to the crown," Cramer added.

Next up is the University of Kansas, the KU Jayhawks. And while Cramer considers it to be one of the most classic names in college basketball, it's had a tough run, thanks to a difficult schedule. Shadowing Kentucky is tough, and many have already written off Kansas.

To Cramer, KU reminds him of General Motors. It's a very well-run company that has had a lot of bad publicity. Do we even need to talk about the deadly ignition recall or the switch issue? Yikes!

"Just like Kansas, I think it would be foolish to write this one off, especially with the stock trading at only 7.6 times next year's earnings estimates," Cramer said.

West

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Parker Jackson-Cartwright #0 of the Arizona Wildcats

The No. 1 seed in the western region is the University of Wisconsin. The story behind this team is all about offense—for every 100 possessions they score an average of 124 points. Wowzer! Head Coach Bo Ryan has been with the school for 14 years and has taken the team to the NCAA tournament every season.

To Cramer, the Wisconsin Badgers remind him of Wells Fargo. It has awesome offense in the form of accelerating revenue growth at 3.8 percent in the latest quarter, from negative 1.5 percent in the first quarter of 2014.

"But even if the Fed's rate hikes don't come as quickly as you're expecting, this remains the best bank to own, as Wells Fargo currently has some of the strongest net interest margins in the business," Cramer said.

The No. 2 seed in the West is University of Arizona, which has been rumored to be the only school that could potentially beat Kentucky and win the tournament. A couple of losses to mediocre teams in December and January had fans questioning if Arizona was really that good. However, it has since recovered, and people are watching them for the win.

In Cramer's perspective, Arizona resembles Facebook because that stock has also been stalled for months; it has traded sideways since the end of September. However, now it looks like it's got its mojo back and could break out on the upside.