More Antibodies against CXCR7 Interaction Partners

The scattershot allele results in an in-frame deletion of 8 amino acids at the junction of the third transmembrane domain and the second intracellular loop of Tre1 that dramatically impairs the function of this GPCR in germ cell migration.

plays an important role in regulation of germ cell migration, polarity , cell adhesion, and cadherin binding. (review)

Down-regulation of E-cadherin causes germ cell dispersal but is not sufficient for transepithelial migration in the absence of Tre1, suggesting a new mechanism for Tre1 GPCR function that links cell polarity, modulation of cell adhesion, and invasion.

Human Chemokine (C-X-C Motif) Receptor 7 (CXCR7) interaction partners

Expression levels of CXCR4 (show CXCR4 Antibodies) and CXCR7 in breast cancer tissues were significantly higher than that in adjacent normal tissues and patients with high CXCR4 (show CXCR4 Antibodies) and CXCR7 expression had a shorter survival time compared with those with low expression.

Data shows the relative expression of CXCR4 (show CXCR4 Antibodies) and CXCR7 in platelets, their dynamic trafficking, how they differentially mediate the functional and survival response to some chemokines, and their prognostic value in coronary artery disease. [review]

CXCR7 expression in colorectal carcinoma was correlated with tumor development and poor prognosis of patients.

TGFbeta1 (show TGFB1 Antibodies)-CXCR7 axis may be a prognostic marker and may provide novel targets for combinational therapies to be used in the treatment of advanced lung cancer in the future

the roles of CXCR4 (show CXCR4 Antibodies), CXCR7, and CXCL12 (show CXCL12 Antibodies) are associated with trophoblastic cells apoptosis and may be linked to the occurrence and development of severe preeclampsia

Sata demonstrate that CXCR7 has a role in the positioning of hem and pallium-subpallium boundary-derived Cajal-Retzius (CR)cells, CXCL12 (show CXCL12 Antibodies) regulating CR cell subpial localization through the combined action of CXCR4 (show CXCR4 Antibodies) and CXCR7.

CXCR7 Antigen Profile

Protein Summary

This gene encodes a member of the G-protein coupled receptor family. Although this protein was earlier thought to be a receptor for vasoactive intestinal peptide (VIP), it is now considered to be an orphan receptor, in that its endogenous ligand has not been identified. The protein is also a coreceptor for human immunodeficiency viruses (HIV). Translocations involving this gene and HMGA2 on chromosome 12 have been observed in lipomas.