CD80 is a highly glycosylated surface protein of 45-60 kDa found on activated B cells, T cells, monocytes, and dendritic cells. Based upon the CD80 cDNA sequence, the molecular weight of the protein core is 30 kDa. The ...

Mathematical theory for random subcloning is presented and discussed in detail. The pairwise end sequencing strategy for mapping and sequencing is presented in a general form; specific examples are analyzed with the aid ...

In this study, I have attempted to understand how Notch signals promote different stages of T cell maturation by examining the regulation of Notch signals on two levels. First, I have used an in vitro culture system to ...

CD4+Foxp3+ T cells (TR) are essential for maintaining self-tolerance, but their sites of action in vivo and homeostatic mechanisms are poorly defined. I examined homing receptor (HR) expression by TR in the steady state ...

Although originally considered to be the archetypal cell activation pathway, signals through immunoreceptor tyrosine-based activation motifs (ITAM) are known to be inhibitory and have recently been appreciated to cross-regulate ...

Adoptive T cell therapy (ACT) for the treatment of established cancers is actively being pursued in clinical trials. However, poor in vivo persistence and maintenance of anti-tumor activity of transferred tumor-specific T ...

University of Washington Abstract The role of CD22 and Bim expression as determinants for the regulation of antigen-specific adaptive immune responses Daphne Yin-Wai Ma Chair of the Supervisory Committee: Professor Edward ...

The epithelially-derived cytokine thymic stromal lymphopoietin (TSLP) plays a key role in the development and progression of allergic disease and has notably been shown to directly promote the inflammatory responses that ...

Multiple sclerosis (MS) is an inflammatory, demyelinating disease of the central nervous system (CNS) mediated by self-reactive, myelin-specific T cells. Both CD4+ and CD8+ T cells play important roles in the pathogenesis ...

Control of B cell development through transitional stages in the periphery is critical for the proper maintenance and selection of mature, functional B cell subsets capable of mediating humoral immunity. We have established ...

Several lines of evidence implicate type I interferons (IFN-I, including IFN-α and IFN-β) in the pathogenesis of systemic lupus erythematosus (SLE). Plasmacytoid dendritic cells (pDCs) are specialized in the production ...

Virus recognition and response by the innate immune system are critical components of host defense against infection. Activation of cell-intrinsic immunity and optimal priming of adaptive immunity against West Nile virus ...

How the interactions of transcription factors (TFs) with specific regions of chromatin control the basis for cellular function and identity remains an open question. Here, analysis of regions of accessible chromatin, which ...

Immune tolerance and activation depend on precise control over the number and function of immunosuppressive Foxp3+ regulatory T (Treg) cells. The importance of interleukin (IL)-2 in immune tolerance is demonstrated by the ...

CD4+ Foxp3+ regulatory T cells (Tr cells) are potent anti-inflammatory cells which naturally suppress autoimmune disease by tempering immune responses to self- and foreign-antigens. Given their integral role in the ...