3 things to know: Giants pull off big upset over Broncos

Denver Broncos quarterback Trevor Siemian regains the football after bobbling it during the first half of an NFL football game against the New York Giants, Sunday, Oct. 15, 2017, in Denver. (AP Photo/Jack Dempsey)(Photo: The Associated Press)

Let's see, you have a 3-1 Denver Broncos team coming off a bye against a struggling 0-5 New York Giants team coming to altitude.

Final score: Giants 23, Broncos 10.

The Broncos, who entered the game as two-touchdown favorites, had a chance to draw closer to the AFC West-leading Kansas City Chiefs, who were favored but lost at home against a struggling Pittsburgh team. Instead, the Broncos fall to 3-2 and the Chiefs still lead the West at 5-1.

Here are three takeaways from Sunday's Broncos loss:

Orleans over the top: The Broncos entered the game with the best run defense in the NFL, but Giants running back Orleans Darkwa rushed for 117 yards on 21 carries. And Darkwa did it with the Giants missing their best lineman, center Weston Richburg, a former CSU standout, who missed the game due to a concussion.

Wideout woes: Sure, the Giants were missing Odell Beckham Jr., Sterling Shepard and Brandon Marshall, but the Broncos were hurting as Sunday night's game went on. Demaryius Thomas was spectacular with 133 yards while he hobbled much of the night, and Emmanuel Sanders and Isaiah McKenzie left the game with ankle injuries.

Pass happy: Broncos quarterback Trevor Siemian had 376 passing yards but suffered two interceptions, including a pick-six, and a fumble. And when he attempts more than 40 or more passes in a game, Denver is 1-6. Of course, a stagnant running game didn't help.

And the Broncos are on the road the next three weeks, at the Chargers, Chiefs and Eagles.