The election of Donald Trump has generated uncertainties and challenges for governments and people around the world. Given the history of contentious relations between the US and Iran and the precarious nature of the multilateral 2015 nuclear deal, one critical area for the new US administration will be how it will approach the Iranian government at a moment when regional conflicts are raging, the health of the global economy is precarious, and geostrategic alliances may be reconfigured. To think through the possible trajectories for US-Iran relations, we have asked the panelists to consider the various interests that are at stake for the Trump presidency, the current Iranian policymaking establishment, and other critical international forces.