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Health Tips / Changes to the Prohibited List 2019

World Anti-Doping Agency announces changes to its Prohibited List for 2019

The World Anti-Doping Agency (WADA) has issued a new Prohibited List of Substances and Methods which will come into effect from 1 January 20119. The List designates what substances and methods are prohibited both in- and out-of-competition, and which substances are banned in particular sports. The WADA List Expert Group reviews the List annually and considers submissions from stakeholders, advancements in science and medical research, trends in doping practices and intelligence gathered from law enforcement etc.

A substance or method is added to the List if it meets two of three criteria: it is performance-enhancing or has the potential to enhance performance; it poses an actual or a potential risk to athletes’ health; or its use is against the spirit of sport.

While there are a number of changes on the List, there are none that would normally be expected to impact on general prescribers based in Ireland. Internationally, Tretoquinol (trimetoquinol), an ingredient in oral cold and flu medications in Asian countries, has been included as an example of a beta-2 agonist.

Macimorelin, soon to be authorised in Europe, is now included as an example of a growth hormone secretagogue in S2.3 Growth Hormone (GH), its fragments and releasing factors.

Daprodustat (GSK1278863) and vadadustat (AKB-6548) are included as hypoxia inducible factor (HIF) activating agents are added as further examples.

Further examples of substances found in dietary supplements are now included

Epiandrosterone has been added as an example of a steroid,

4-methylpentan-2-amine is added as another name for 1,3-dimethylbutylamine (DMBA).

Two additional analogues of methylhexaneamine were added as examples: 5-methylhexan-2-amine (1,4-dimethylpentylamine) and 3-methylhexan-2-amine (1,2-dimethylpentylamine).

The examples of metabolites of steroids which the body does not naturally produce has been simplified. It now only includes those known to be found in supplements or used as masking agents. (e.g. to affect the “steroid profile”).

Some substances are now also included by their International Non-proprietary Name (INN); Dimetamfetamine (dimethylamphetamine), Enobosarm (ostarine), Examorelin (hexarelin) and Lenomorelin (ghrelin).

The updates to the 2019 List will be reflected in the Eirpharm Drugs in Sport Database, Sport Ireland Athlete’s wallet cards, MIMS Ireland, and the Medication Checker App which allows users to access the live Eirpharm Drugs in Sport Database.

More information is available from Sport Ireland at (01) 8608818, website: www.sportireland.ie/Anti-Doping, www.eirpharm.com (email: pharmacy@eirpharm.com) and National Governing Bodies of Sport.