Exeter Chiefs props Ben Moon, who is one of eight uncapped players to be selected, and Alec Hepburn have been called up to replace Mako Vunipola, who was injured alongside brother Billy in Saracens' Champions Cup win away to Glasgow on Sunday.

"We can only control what we can control and injuries have happened," Jones told the RFU. "It gives an opportunity for some good new players to play some important Tests for England while players who have been in the squad before, will have to take on more responsibility."

Chris Ashton has also been named in the squad, despite not playing a minute of action for Sale this season. Ashton's seven-week ban for a dangerous tackle in pre-season ended this week and the winger is set to start Sale's Challenge Cup fixture against Connacht this weekend.

England's Autumn Fixtures

South Africa

Nov. 3

New Zealand

Nov. 10

Japan

Nov. 17

Australia

Nov. 24

Owen Farrell and Dylan Hartley have been named as co-captains for the four Tests, as England step up their preparations for next year's Rugby World Cup in Japan, while Joe Cokanasiga, Nathan Earle, Ted Hill, Zach Mercer, Michael Rhodes, Nick Schonert and Elliott Stooke could all make their England debuts.

Dave Attwood and Don Armand miss out, as well as James Haskell and Dan Cole, while Ellis Genge, Jonathan Joseph, Dan Robson and Anthony Watson are other notable players who are unavailable for selection due to injury.