The four major brain-specific cell types in the brain are; (i) neurons, which transmit and process information via electrical signals, (ii) oligodendrocytes, which insulate neuronal axons with fatty sheets called myelin to ensure fast and complete electrical signal transduction, (iii) microglia, which provide defence against potential infections in the brain and, (iv) astrocytes, that serve many important roles such as immune defence, cleaning up debris, ensuring proper neuronal functioning and also communication with other cells. These cells, and indeed all living cells, have a wide range of proteins called receptors on their surface, which are activated by signalling molecules. EBI2 is one such receptor that plays very important roles in the biology of immune cells, where it regulates antibody production to fight infections.

dc.format

1 volume

dc.language.iso

en

dc.publisher

Trinity College (Dublin, Ireland). Department of Physiology

dc.relation.isversionof

http://stella.catalogue.tcd.ie/iii/encore/record/C__Rb16086490

dc.subject

Molecular Neuropharmacology, Ph.D.

dc.subject

Ph.D. Trinity College Dublin

dc.title

The signalling and function of EB12 in the central nervous system

dc.type

thesis

dc.type.supercollection

thesis_dissertations

dc.type.supercollection

refereed_publications

dc.type.qualificationlevel

Doctoral

dc.type.qualificationname

Doctor of Philosophy (Ph.D.)

dc.rights.ecaccessrights

openAccess

dc.format.extentpagination

pp 142

dc.description.note

TARA (Trinity’s Access to Research Archive) has a robust takedown policy. Please contact us if you have any concerns: rssadmin@tcd.ie