In 2010, Imperioli was signed on to play the lead in the ABC TV show, Detroit 1-8-7.[6]

Working with the writer Gabriele Tinti, he wrote the text Pride for Tinti's book New York Shots, and participated in a reading of The Way of the Cross at the Queens Museum of Art in 2011.[7]

He won the "Tournament of Stars" competition on the cooking show Chopped in 2014, sending $50,000 to his designated charity the Pureland Project, an organization which builds and maintains schools in rural Tibet. In 2016, he guest starred as the angel Uriel on the Fox show Lucifer.