Current Research and Scholarly Interests
We study the primary cilium, a surface-exposed organelle required for vision, olfaction and developmental signaling and whose dysfunction leads to obesity, skeletal malformations and kidney cysts. To decode the fundamental principles of ciliary trafficking and to understand how trafficking shapes signaling at the primary cilium, we leverage a broad expertise in biochemistry, proteomics, cell biology and in vitro reconstitution.

Current Research and Scholarly Interests
Kari Nadeau, MD, PhD, Allergy, Immunology and AsthmaOur research interests in the laboratory focus on the role of human T cells, specifically natural regulatory T cells (Treg, in immunological diseases. We aim to differentiate the mechanisms of action of regulatory T cell suppressive function. We study how pollution, such as diesel exhause, disrupt Treg suppressive function and how chemokines, like lymphotactin, enhance Treg suppressive function. We also study Treg function in tolerance.