Previous GeneCards Identifiers for SEC63 Gene

Summaries for SEC63 Gene

Entrez Gene Summary for SEC63 Gene

The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The protein encoded by this gene and SEC62 protein are found to be associated with ribosome-free SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. The encoded protein is an integral membrane protein located in the rough ER. [provided by RefSeq, Jul 2008]

Role of human sec63 in modulating the steady-state levels of multi-spanning membrane proteins.(PMID: 23166619)Mades A … Prange R(PloS one 2012)2358

Patients with isolated polycystic liver disease referred to liver centres: clinical characterization of 137 cases.(PMID: 20408955)Van Keimpema L … Drenth JP(Liver international : official journal of the International Association for the Study of the Liver 2011)34458