40],[41] In patients with diabetes, LI is more frequently caused by branch orifice atheromatous disease than hypertensive arteriopathy, the latter of which is the predominant vascular pathology underlying strictly deep/mixed CMB.

This regional association with dementia subtypes is consistent with the hypothesis that lobar cerebral microbleeds reflect cerebral amyloid angiopathy, which is consistent with Alzheimer's disease, while those in deep areas reflect hypertensive arteriopathy, which is important in vascular dementia," Lenore Launer, Ph.

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