Der-Shing Helmer, known for her work on The Meek, answered a few questions on Tumblr on her experience publishing a comic through a small press publisher, 4th Dimension Entertainment. 4DE also publishes Hanna is Not a Boy’s Name, Lackadaisy and The Phoenix Requiem.
EDIT: (She’s taken the post down, sorry! Original post is here. http://alexds1.tumblr.com/post/12725055029/publishing-comics-through-a-small-publisher)