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Items 1 to 100 of about 246

1. Namboodiri N, Krishnamoorthy KM: Type A aortic dissection with partial ostial occlusion of left main coronary artery.Eur J Echocardiogr; 2008 Jan;9(1):139-40[Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Type A aortic dissection with partial ostial occlusion of left main coronary artery.

The short axis view of the aorta showed partial obstruction of the left main coronary artery (LMCA) by the intimal flap with turbulent flow at its ostium.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

BACKGROUND AND OBJECTIVE: Left main coronary artery disease (LMCA) is still a widely accepted indication for coronary artery bypass surgery.

Intermediate LMCA disease, however, often cannot be evaluated reliably on the basis of clinical and angiographic information alone.

This study was performed to compare the accuracy of visual angiographic assessment of intermediate LMCA stenoses by experienced interventional cardiologists with functional assessment by FFR in a patient population with excellent long-term outcome after deferral of surgery on the basis of FFR measurements.

PATIENTS AND METHODS: 24 of 51 consecutive patients with intermediate LMCA disease were deferred from surgery based on an FFR value of > or = 0.75.

CONCLUSION: The functional significance of intermediate or equivocal LMCA lesions should not be based on visual assessment alone, even when performed by experienced interventional cardiologists.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

INTRODUCTION: The 2008 World Health Organization classification of myeloid neoplasms includes the diagnostic category, myelodysplastic/myeloproliferative neoplasms (MDS/MPN), which encompasses those rare clonal myeloid proliferations that at initial presentation, show overlapping myeloproliferative and myelodysplastic features, making classification as either a myelodysplastic syndrome (MDS) or myeloproliferative neoplasm (MPN) problematic.

Notably, the morphological features typical of MDS/MPNs are not specific and can be seen in other myeloid neoplasms at presentation or as part of disease progression or transformation.

CONCLUSION: The most appropriate classification of myeloid neoplasms presenting with hybrid myelodysplastic/myeloproliferative features requires a comprehensive clinical and laboratory assessment with careful integration of the morphological, immunophenotypic, genetic, and clinical characteristics.

[Language] eng

[Publication-type] Journal Article; Review

[Publication-country] England

4. Sokmen G, Tuncer C, Sokmen A, Suner A: Clinical and angiographic features of large left main coronary artery aneurysms.Int J Cardiol; 2008 Jan 11;123(2):79-83[Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Clinical and angiographic features of large left main coronary artery aneurysms.

Coronary artery aneurysms are defined as coronary dilatations which exceed the diameter of normal adjacent segments by 1.5 times.

Left main coronary artery (LMCA) is the least frequently involved artery with a prevalence of 0.1%.

Majority of coronary artery aneurysms are atherosclerotic in origin.

A number of complications have been reported to occur during the course of the disease including thrombosis and distal embolization, myocardial ischemia and/or infarction, dissection, vasospasm, calcification, fistulization and very rarely rupture.

Large aneurysms of LMCA represent a potentially fatal condition even without concomitant atherosclerotic coronary disease.

Because of rarity of coronary artery aneurysms, it is difficult to standardize treatment.

In this article, we presented 4 cases of large LMCA aneurysms with various clinical and angiographic features.

[MeSH-major] Coronary Aneurysm / diagnosis. Coronary Angiography

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[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

Excimer laser has been successfully applied to complex atherosclerotic plaques in acute coronary syndromes; however, its role in debulking in left main coronary artery disease has not been fully explored.

Details of a series of 20 patients who underwent excimer laser revascularization of a spectrum of left main coronary artery lesions are presented.

The left main coronary artery was characterized as protected, semi-protected, poorly protected, or unprotected, depending on the presence or absence of patent bypass grafts to the left anterior descending (LAD) and circumflex (CX) arteries.

A fully protected left main coronary artery (LMCA) was present in only 20% of the patients.

RESULTS: Forty-eight patients underwent balloon angioplasty; 36 of whom had lesions in the ostial right coronary artery, and 12 of whom had lesions in the left main coronary artery (LMCA).

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(PMID = 19353700.001).

[ISSN] 0160-9289

[Journal-full-title] Clinical cardiology

[ISO-abbreviation] Clin Cardiol

[Language] eng

[Publication-type] Evaluation Studies; Journal Article

[Publication-country] United States

7. Kim JW, Seo HS, Rha SW, Park CG, Oh DJ: Acute myocardial infarction in a 14-year old boy by thrombotic occlusion of the left main coronary ostium.Int J Cardiol; 2006 Mar 8;107(3):430-1[Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Acute myocardial infarction in a 14-year old boy by thrombotic occlusion of the left main coronary ostium.

We report the case of a 14-year old boy who was diagnosed with acute myocardial infarction complicated by cardiogenic shock and was treated by primary stenting of thrombotic occluded left main ostium.

In lesions associated with LMCA-related events, lumen CSA was smaller, plaque burden was larger, and the remodeling index was greater than in lesions not associated with cardiac events, but only non-NR was an independent predictor of LMCA-related events in patients with mild LMCA disease (hazard ratio 4.095; 95% CI, 1.275-13.149; p = 0.018).

CONCLUSIONS: Angiographically mild LMCA disease was more frequently associated with NR, and NR was associated with fewer LMCA-related cardiac events in patients with mild LMCA lesions.

[Journal-full-title] Journal of Korean medical science

[ISO-abbreviation] J. Korean Med. Sci.

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] Korea (South)

[Other-IDs] NLM/ PMC2722009

11. Imamaki M, Matsuura K, Sakurai M, Shimura H, Ishida A, Miyazaki M: Evaluation of early and midterm results of offpump coronary artery bypass in patients with left main disease.J Card Surg; 2009 Mar-Apr;24(2):162-6[Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Evaluation of early and midterm results of offpump coronary artery bypass in patients with left main disease.

PURPOSE: This study evaluated the early and midterm results of offpump coronary artery bypass (OPCAB) for left main coronary artery (LMCA) stenosis.

METHODS: Patients treated between November 2001 and December 2006, during which isolated coronary artery bypass grafting (CABG) was performed without cardiopulmonary bypass in principle, were included.

Isolated CABG was performed in 206 patients, of whom 62 (30.1%) had LMCA stenosis >50%.

Coronary artery fistulas (CAF) are uncommon entities often associated with myocardial ischemia and high output failure.

We report a case of left main coronary artery (LMCA) fistula to the coronary sinus (CS), which was associated with high-output bi-ventricular failure, and moderate mitral (MR) and tricuspid regurgitation (TR), related to the volume overload and annular dilatation.

This was tackled elegantly by off-pump CABG to protect the territories supplied by the LMCA, followed by ligation of the fistula.

Although supravalvular aortic stenosis with LMCA stenosis is a very rare congenital abnormality, this clinical entity can be successfully corrected with detailed and selected surgical procedures.

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(PMID = 19438785.001).

[ISSN] 1540-8191

[Journal-full-title] Journal of cardiac surgery

[ISO-abbreviation] J Card Surg

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] United States

[Chemical-registry-number] 0 / Polyethylene Terephthalates

14. Tatli E: Thrombotic occlusion of the ostial left main coronary artery in a patient with acute coronary syndrome.Neth Heart J; 2009 Aug;17(7-8):295-6[Fulltext service] Download fulltext PDF of this article and others, as many as you want.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Thrombotic occlusion of the ostial left main coronary artery in a patient with acute coronary syndrome.

Ostial left main coronary artery (LMCA) occlusion is rarely seen in patients with acute coronary syndrome.

Acute coronary syndrome resulting from an LMCA occlusion is associated with a significant morbidity and mortality rate, if it is managed with fibrinolysis.

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(PMID = 19689656.001).

[ISSN] 1540-8183

[Journal-full-title] Journal of interventional cardiology

[ISO-abbreviation] J Interv Cardiol

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

16. Leesar MA, Mintz GS: Hemodynamic and intravascular ultrasound assessment of an ambiguous left main coronary artery stenosis.Catheter Cardiovasc Interv; 2007 Nov 1;70(5):721-30[Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Hemodynamic and intravascular ultrasound assessment of an ambiguous left main coronary artery stenosis.

The assessment of the left main coronary artery (LMCA) stenosis by angiography is not reliable, and noninvasive tests are incapable of discriminating ischemia caused by LMCA versus other stenoses.

Among patients with LMCA stenosis, both fractional flow reserve and intravascular ultrasound parameters would determine the severity of stenosis and predict the event rates.

This review outlines the evidence in support of their routine use for the assessment of an ambiguous LMCA stenosis.

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[Copyright] (c) 2007 Wiley-Liss, Inc.

(PMID = 17960644.001).

[ISSN] 1522-1946

[Journal-full-title] Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions

[ISO-abbreviation] Catheter Cardiovasc Interv

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] United States

17. Lindsey JB, Brilakis ES, Banerjee S: Acute coronary syndrome due to extrinsic compression of the left main coronary artery in a patient with severe pulmonary hypertension: successful treatment with percutaneous coronary intervention.Cardiovasc Revasc Med; 2008 Jan-Mar;9(1):47-51[Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Acute coronary syndrome due to extrinsic compression of the left main coronary artery in a patient with severe pulmonary hypertension: successful treatment with percutaneous coronary intervention.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

Percutaneous coronary interventions (PCI) in patients with severely depressed left ventricular (LV) function and in those with chronic total occlusions are technically challenging and at high risk of complications.

Here we report a case of successful retrograde transradial recanalization and stenting of a chronically occluded left main coronary artery (LMCA) from a saphenous vein graft supported by the Impella Recover LP 2.5 assist device.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

BACKGROUND: Angiographic assessment of left main coronary artery (LMCA) stenosis is often difficult and unreliable.

To date, intravascular ultrasound (IVUS) is used to determine the significance of lesions in patients with LMCA stenosis of uncertain significance.

We aimed to prospectively show the ability of multidetector computed tomography (MDCT) to assess LMCA luminal and plaque dimensions, and to characterize atherosclerotic plaque, as compared to IVUS and quantitative coronary angiography (QCA), in patients with angiographically uncertain LMCA stenosis.

CONCLUSION: A high degree of correlation was found between MDCT and IVUS regarding the assessment of minimal lumen diameter and area, lumen area stenosis and plaque burden as well as plaque characterization in patients with angiographically borderline LMCA stenosis.

Therefore, in patients selected for non-invasive coronary tree evaluation, MDCT may provide a valuable tool for the assessment, decision-making and follow-up of patients with uncertain LMCA disease.

(PMID = 18165931.001).

[ISSN] 1569-5794

[Journal-full-title] The international journal of cardiovascular imaging

[ISO-abbreviation] Int J Cardiovasc Imaging

[Language] eng

[Publication-type] Comparative Study; Journal Article

[Publication-country] United States

21. Duygu H, Yavuzgil O, Erturk U, Zoghi M, Ozerkan F: ST-segment elevation in lead augmented vector right may also be caused by diffuse left main coronary artery vasospasm without fixed stenosis.Clin Cardiol; 2008 Apr;31(4):179-82[Fulltext service] Download fulltext PDF of this article and others, as many as you want.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] ST-segment elevation in lead augmented vector right may also be caused by diffuse left main coronary artery vasospasm without fixed stenosis.

The ST-segment elevation in this aVR in the patient with clinically suspected acute coronary syndrome suggests a strong possibility of left main coronary artery (LMCA) obstruction due to fixed stenosis.

In this article, we report the first case, to our knowledge, of ST-segment elevation in lead aVR due to diffuse LMCA spasm.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Anomalous origin of left main coronary artery: the value of myocardial scintigraphic and spiral computed tomography scans.

Anomalous origin of the left main coronary artery (LMCA) from the right sinus of the Valsalva or the proximal right coronary artery (RCA) is one of the most clinically important anomalies of coronary circulation.

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(PMID = 16791809.001).

[ISSN] 1506-9680

[ISO-abbreviation] Nucl Med Rev Cent East Eur

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] Poland

[Chemical-registry-number] AD84R52XLF / Thallium

23. Fukuhara T, Kakinoki Y: [Clinical features of a new category, myelodysplastic/myeloproliferative diseases, defined by WHO classification].Rinsho Byori; 2006 Mar;54(3):243-9[Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

The WHO classification published in 2001 defined a new category of hematological disease, myelodysplastic/myeloproliferative diseases (MDS/MPD), that have both myelodysplasia and myeloproliferation at the time of initial presentation.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Distal left main coronary bifurcation lesions predict worse outcome in patients undergoing percutaneous implantation of drug-eluting stents: results from the Drug-Eluting Stent for the Treatment of Left Main Disease (DISTAL) Study.

OBJECTIVES: We investigated the clinical outcome of stenting of unprotected left main coronary artery (LMCA).

There were significant differences in major adverse cardiac events at 1 (p = 0.014) and 2 years (p = 0.002) between group B (19.8%, 25.0%) and group A (9.1%, 10.4%), mainly due to increased target-vessel revascularization (16.7, 21.9% in group B vs. 6.1, 7.3% in group A, p = 0.006 and 0.001, respectively).

The double-stent technique was associated with worse outcomes at 1 year in group B compared to group A.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

OBJECTIVES: The aim of this trial was to compare the safety and efficacy of paclitaxel-eluting stents (PES) and sirolimus-eluting stents (SES) for treatment of unprotected left main coronary artery (uLMCA) disease.

The primary end point was the combined incidence of death, myocardial infarction, and target lesion revascularization (TLR) at 1 year.

The secondary end point was angiographic restenosis on the basis of the LMCA area analysis at follow-up angiography.

RESULTS: At 1 year the cumulative incidence of death, myocardial infarction, or TLR was 13.6% in the PES and 15.8% in the SES group (relative risk [RR]: 0.85, 95% confidence interval [CI]: 0.56 to 1.29, p = 0.44).

CONCLUSIONS: Implantation of either PES or SES in uLMCA lesions is safe and effective; both of these drug-eluting stents provide comparable clinical and angiographic outcomes. (Drug-Eluting-Stents for Unprotected Left Main Stem Disease [ISAR-LEFT-MAIN]; NCT00133237).

28. Batyraliev TA, Fettser DV, Karben ZA, Sidorenko BA: [Stenting of unprotected left main coronary artery: complications during 3 years follow up].Kardiologiia; 2009;49(2):22-6[Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] [Stenting of unprotected left main coronary artery: complications during 3 years follow up].

Aim of investigation was to study complications during 3 years follow up of patients after implantation of standard metal stents (SMS) in unprotected left main coronary artery (LMCA).

Patients with high risk of surgery (n=124) with stenting of unprotected LMCA performed between August 2002 and November 2004 were included in this investigation.

Peripheral complications were noted in 1 case: in one patient pseudoaneurism of femoral artery developed and was successfully resolved by compression under ultrasound control.

Despite high success of PCI of unprotected LMCA with the use of SMS and relatively low percent of restenosis it is necessary to use this method carefully in the treatment of patients with lesions in unprotected LMCA.

We consider PCI in unprotected LMCA justified only in patients with high risk of surgical intervention who are not suitable candidates for coronary bypass surgery.

[Title] The finding of a reciprocal whole-arm translocation t(X;12)(p10;p10) in association with atypical chronic myeloidleukaemia.

Main characteristics are marked dysgranulopoiesis, bone marrow dysfunction and the failure to demonstrate the presence of the Philadelphia chromosome or BCR/ABL fusion gene normally associated with CML t(9;22)(q34;q11).

Most cases of aCML have one or more karyotypic abnormalities.

We highlight a clinical presentation of aCML associated with an acquired reciprocal whole-arm translocation (WAT), t(X;12)(p10;p10), which to our knowledge has not yet been described.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

We hypothesized that hitherto unrecognized, cytogenetically cryptic tyrosine kinase fusions may be common in non-classical or atypical myeloproliferative neoplasms and related myelodysplastic/myeloproliferative neoplasms.

RESULTS: No abnormalities involving tyrosine kinases were detected; however, nine cytogenetically cryptic copy number imbalances were detected in seven patients, including hemizygous deletions of RUNX1 or CEBPA in two cases with atypical chronic myeloid leukemia.

Analysis of other transcription factors known to be frequently mutated in acute myeloid leukemia revealed NPM1 mutations in six (3%) and WT1 mutations in two (1%) patients with myelodysplastic/myeloproliferative neoplasms.

[Publication-country] Italy

[Other-IDs] NLM/ PMC2930947

31. Kannam HC, Satou G, Gandelman G, DeLuca AJ, Belkin R, Monsen C, Aronow WS, Peterson SJ, Krishnan U: Anomalous origin of the left main coronary artery from the right sinus of Valsalva with an intramural course identified by transesophageal echocardiography in a 14 year old with acute myocardial infarction.Cardiol Rev; 2005 Sep-Oct;13(5):219-22[Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Anomalous origin of the left main coronary artery from the right sinus of Valsalva with an intramural course identified by transesophageal echocardiography in a 14 year old with acute myocardial infarction.

Coronary artery anomalies have an incidence of 0.6% to 1.3% in angiographic studies and 0.3% in an autopsy series.

Anomalous origin of the left main coronary artery (LMCA) from the right sinus of Valsalva (RSOV) represents a small fraction (1.3%) of these anomalies, with an overall prevalence of 0.017% to 0.03% in angiographic studies.

We present a case report of a 14-year-old patient with an LMCA arising from the RSOV with an initial intramural course, presenting with acute myocardial infarction (AMI) as the first indication of the anomaly.

METHODS: We used IVUS to compare ostial lesions in the left main coronary (LMCA, n = 45) versus the right coronary artery (RCA, n = 50).

RESULTS: Patient age was 66 +/- 11 years in the LMCA group and 66 +/- 11 years in the RCA group; 56% of the LMCA ostial lesions and 46% of RCA ostial lesions were in males, and 35% of the LMCA ostial lesions and 20% of the RCA ostial lesions were in diabetics.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

OBJECTIVES: The purpose of this study was to evaluate the efficacy of an intravascular ultrasound (IVUS)-guided strategy for patients with angiographically indeterminate left main coronary artery (LMCA) disease.

BACKGROUND: The assessment of LMCA lesions using coronary angiography is often challenging; IVUS provides useful information for assessment of coronary disease.

METHODS: Intravascular ultrasound was performed on 121 patients with angiographically normal LMCAs to determine the lower range of normal minimum lumen area (MLA), defined as the mean - 2 SD.

We conducted IVUS studies on 214 patients with angiographically indeterminate LMCA lesions, and deferral of revascularization was recommended when the MLA was larger than this predetermined value.

RESULTS: The lower range of normal LMCA MLA was 7.5 mm(2).

Of the patients with angiographically indeterminate LMCAs, 83 (38.8%) had an MLA <7.5 mm(2), and 131 (61.2%) an MLA > or =7.5 mm(2).

Left main coronary artery revascularization was performed in 85.5% (71 of 83) of patients with an MLA <7.5 mm(2) and deferred in 86.9% (114 of 131) of patients with an MLA > or =7.5 mm(2).

Multivariate predictors of cardiac events were age, smoking, and number of non-LMCA vessels diseased.

CONCLUSIONS: Intravascular ultrasound is an accurate method to assess angiographically indeterminate lesions of the LMCA.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Electrocardiographic prediction of short-term prognosis in patients with acute myocardial infarction associated with the left main coronary artery.

PURPOSE: The purpose of this study was to assess the usefulness of electrocardiogram on admission to predict short-term prognosis in patients with acute myocardial infarction (AMI) associated with left main coronary artery (LMCA).

METHODS: Electrocardiogram was obtained on admission in 41 patients with AMI associated with LMCA who underwent reperfusion therapy.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

OBJECTIVE: To discuss from the clinical and cytogenetic aspect that part of patients now diagnosed as myelodysplastic syndromes (MDS) could be diagnosed early as leukemia and be classified as subacutemyeloid leukemia (Sub-AML).

Among them 42 had +8 chromosome aberration, 16 had -7/7q-, and 55 had normal karyotypes and more than 0.10 blast cells in the bone marrow.

Short term culture and G-banding techniques and in some specimens fluorescence in situ hybridization (FISH) method were used to do chromosome analysis.

RESULTS: Among the detected chromosome aberrations, +8 was the most frequent (42.8%) and then -7/7q-(15.0%); 42 patients with +8 had median blast cell count of 0.08, within a median of 18 months follow-up period 40.0% of the patients evolved to frank leukemia (FL) and the median overall survival was 20 months.

CONCLUSIONS: Both the +8 and -7/7q- groups have malignant leukemic cell clone, and run a subacute and progressive clinical course; it is suggested they might be classified into Sub-AML.

[ISO-abbreviation] Int. J. Cardiol.

[Language] eng

[Publication-type] Letter; Research Support, Non-U.S. Gov't

[Publication-country] Netherlands

40. Murasato Y, Horiuchi M, Otsuji Y: Three-dimensional modeling of double-stent techniques at the left main coronary artery bifurcation using micro-focus X-ray computed tomography.Catheter Cardiovasc Interv; 2007 Aug 1;70(2):211-20[Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Three-dimensional modeling of double-stent techniques at the left main coronary artery bifurcation using micro-focus X-ray computed tomography.

BACKGROUND: Various double-stent techniques using drug-eluting stents have been proposed to treat the left main coronary artery (LMCA) bifurcation.

However, use of these techniques is frequently associated with focal restenosis at the ostium of the left circumflex coronary artery (LCX).

OBJECTIVES: To examine the results of double-stent techniques, using a silicon model of the LMCA bifurcation and three-dimensional (3D) reconstruction images created with micro-focus X-ray computed tomography (MFCT).

METHODS: Crush, kissing, and modified T stentings were performed with bare metal stents in a LMCA bifurcation model.

The stents were then inspected using MFCT at a minimal resolution of 0.06 mm.

RESULTS: Gaps in stent apposition to the vessel were observed at the site of stent overlap in the distal LMCA with all stenting techniques.

In crush stenting, when the left anterior descending artery stent overlapped the LCX stent, the latter was crushed on the myocardial side of the vessel, and a gap was observed on the nonmyocardial side, at the LCX ostium.

CONCLUSIONS: Close apposition of the stent to the vessel at the ostium of the LCX is difficult to achieve at the LMCA bifurcation, regardless of which double-stent technique is employed, due to the site's wide bifurcation angle and complex 3D structure.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Prevalence of left main coronary artery disease among patients with ischemic heart disease: insights from the Tehran Angiography Registry.

AIM: This study was designed to investigate the prevalence of left main coronary artery (LMCA) significant stenosis among patients with stable angina (SA) or acute coronary syndromes (ACSs) and to assess the influence of demographic and clinical profiles on these findings.

The patients' characteristics were compared in subgroups with and without LMCA disease.

RESULTS: Significant and minimal LMCA stenoses were found in 659 (3.6%) and 1157 (6.4%) patients, respectively.

In the patients with normal or minimal stenoses of the other coronary arteries, cigarette smoking (OR=3.749, 95% CI=1.698 to 8.070) was found to be the independent risk factor of isolated LMCA disease.

Luminal stenosis >50% in the right coronary artery, the left circumflex artery, and the left anterior descending artery was significantly more frequent in association with LMCA disease.

CONCLUSIONS: The patients with LMCA disease were more likely to be male, older, and have diabetes mellitus or dyslipidemia, whereas cigarette smoking was found as an independent predictor of isolated LMCA.

There was a strong correlation between the severity of LMCA stenosis and coexistent diseases in the rest of the coronary arteries.

Between January 2003 and December 2006, a total of 287 patients undergoing percutaneous coronary intervention for LMCA lesions were consecutively registered.

In conclusion, PES implantation provides a safe, effective therapy for unprotected LMCA disease and decreases the risk of major adverse cardiac events compared with BMS at a mean follow-up of 35 months.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

BACKGROUND: Arterial switch operation is standard repair for complete transposition of the great arteries (TGA).

Coronary artery abnormalities are the most common cause of morbidity and mortality in the acute postoperative phase.

This study was designed to determine whether coronary artery pulse Doppler flow patterns obtained by transesophageal echocardiography during the arterial switch operation are correlated with acute postoperative outcomes.

CONCLUSION: The initial favorable outcomes of patients with normal left ventricular function after stenting of unprotected LMCA stenosis were sustained for up to 5 years.

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(PMID = 16904209.001).

[ISSN] 1874-1754

[Journal-full-title] International journal of cardiology

[ISO-abbreviation] Int. J. Cardiol.

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] Netherlands

46. Noestelthaller A, Probst A, König HE: Branching patterns of the left main coronary artery in the dog demonstrated by the use of corrosion casting technique.Anat Histol Embryol; 2007 Feb;36(1):33-7[Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Branching patterns of the left main coronary artery in the dog demonstrated by the use of corrosion casting technique.

As many investigators use dogs as experimental models in catheterization-, ligation-, and collateral flow studies, knowledge and awareness of the canine left coronary artery anatomical variation is vital for differentiation between canine and human coronary arterial patterns and canine and human coronary congenital anomalies with or without circulatory importance.

The present study was performed to examine and review the various principal subdivisions of the canine left main coronary artery (LMCA) in vascular casts of 20 hearts obtained from cadavers of clinically normal dogs of various ages, breeds and of either sex.

A corrosion casting technique using an acrylic resin called Tensol Cement No. 70 and a lower-viscosity acrylic resin called Mercox were used to produce a three-dimensional model of the canine coronary arteries.

In our study, all dog hearts were left preponderant and the patterns of the principal subdivisions of the LMCA were grouped into three types: Type 1 occurred in seven of the 20 dogs (35%), Type 2 in 12 of 20 dogs (60%) and Type 3 in one instance (5%).

A comparison between the canine divisional patterns of the LMCA in the vascular casts and those reported in the literature showed major agreement.

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(PMID = 17266665.001).

[ISSN] 0340-2096

[Journal-full-title] Anatomia, histologia, embryologia

[ISO-abbreviation] Anat Histol Embryol

[Language] eng

[Publication-type] Journal Article

[Publication-country] Germany

47. Bitigen A, Karavelioglu Y, Kaynak E, Yilmaz MB: A case of myocardial infarction due to acute left main coronary artery occlusion presenting with peculiar electrocardiographic changes.Int J Cardiovasc Imaging; 2006 Jun-Aug;22(3-4):343-7[Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] A case of myocardial infarction due to acute left main coronary artery occlusion presenting with peculiar electrocardiographic changes.

Myocardial infarction (MI) due to acute obstruction of the left main coronary artery (LMCA) occlusion is a medical emergency, requiring early and prompt diagnosis and revascularization, and unless it is treated, it will frequently result in cardiogenic shock, which has a high fatality rate.

ECG is the easiest diagnostic method in the early diagnosis of the acute coronary syndromes and in deciding on the early invasive intervention in the high risk group.

At the time of the urgent coronary angiography, it was noticed that the LMCA was totally occluded.

This case has been presented in order to emphasize that peculiar changes might bring about devastating consequences as in our rare case, showing acute left main coronary artery occlusion, and ST segment elevation only in the AVR on the 12-lead ECG along with upward deflection of ST segment vector might be critical for accurate diagnosis.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

AcmI and AcmL methylate also hydroxyphenyl-amino propanoic acids such as p-tyrosine, m-tyrosine, or 3,4-dihydroxy-l-phenylalanine (DOPA) but at a lower rate than 3-HK.

AcmI and AcmL show sequence similarity to various C- and O-methyltransferases from bacteria.

Remarkably, computational remodelling of AcmI and AcmL structures revealed significant similarity with the 3-D structures of type 1 O-methyltransferases from plants such as caffeic acid O-methyltransferase (COMT) and other phenylpropanoid methyltransferases.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title]Left main coronary artery disease does not affect the outcome of off-pump coronary artery bypass grafting.

BACKGROUND: Left main coronary artery (LMCA) stenosis (≥50%) has historically been recognized as a risk factor among patients undergoing coronary artery bypass grafting.

METHODS: From January 2002 to December 2008, a total of 665 patients, 268 of whom had significant LMCA disease, underwent isolated off-pump coronary artery bypass surgery at Shiga Medical University Hospital.

We compared the clinical results in the 237 patients with LMCA stenosis (LMCA group) with those in the propensity score-matched 237 patients without LMCA stenosis (non-LMCA group).

We performed off-pump surgery in all coronary artery bypass grafting cases with no exclusion criteria.

Two patients in the LMCA group (2 of 237; 0.8%) and four in the non-LMCA group (4 of 237; 1.7%) died within 30 days after surgery.

The rates of six-year freedom from all cause death were 87.3% and 60.7% in the LMCA group and non-LMCA group, respectively (p = 0.17), and the corresponding rates for the combined endpoint of cardiac death, myocardial infarction, angina pectoris, repeat coronary intervention, and heart failure were 80.4% and 70.4% (p = 0.98).

CONCLUSIONS: Off-pump coronary artery bypass grafting is feasible and safe in patients with critical LMCA stenosis and LMCA disease is not recognized as a risk factor after off-pump coronary artery bypass grafting in either the short or the long term.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Two-year outcomes of the sirolimus-eluting stent according to unprotected left main lesion.

BACKGROUND: The data of long-term outcomes of sirolimus-eluting stent (SES) according to lesion location of unprotected left main coronary artery (LMCA) is scarce.

HYPOTHESIS: The purpose of this study was to evaluate the long-term outcomes after implantation of the SES in LMCA.

METHODS: A total of 84 patients (51 males) who had undergone SES implantation for the treatment of native LMCA stenosis were enrolled.

Although angiographic success and in-hospital MACE rates were similar in both groups with 1 cardiac death due to acute stent thrombosis in group 2, at 2-year follow-up, the MACE rate was significantly higher in group 2 than in group 1 at 2 years (22.2% vs 2.6%, respectively, P = 0.008).

CONCLUSIONS: Interventional treatment using SES in left main lesions showed favorable short-term and long-term outcomes in selected patients with lesion location being an important determinant of clinical and angiographic outcomes.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Effectiveness of drug-eluting stent implantation for patients with unprotected left main coronary artery stenosis.

This study was aimed to evaluate outcomes of patients with unprotected left main coronary artery (LMCA) stenosis who were treated with drug-eluting stents.

Sixty-three consecutive patients with unprotected LMCA stenosis were treated with sirolimus-eluting stents in 52 (83%) patients and paclitaxel-eluting stents in 11 (17%) patients, in whom percutaneous intervention was considered the sole alternative because of high surgical risk and/or patient preference.

Involvement of the distal LMCA was observed in 46 (73%) patients.

In conclusion, drug-eluting stent placement for unprotected LMCA stenosis may be a feasible therapeutic alternative in patients at high surgical risk.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

Dual left anterior descending coronary artery (LAD) distribution with either of the vessels originating from the left main coronary artery (LMCA) and the right aortic sinus of Valsalva is an extremely rare coronary artery anomaly.

Here we discuss a 45-year-old male who presented with non-ST-elevation anterior wall myocardial infarction due to near-total occlusion of the LAD immediately after its origin from the LMCA.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

Theoretical and experimental studies showed that in conjunction with a dual-side laser illumination scheme, the proposed LMCA design allows a simultaneous uniform irradiation of as many as 550 working capillaries.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

AIMS: This study was designed to compare the clinical and angiographic outcomes of paclitaxel-eluting stent (PES) and bare metal stent (BMS) implantation for unprotected left main coronary artery (LMCA) bifurcation narrowing.

METHODS AND RESULTS: From November 2003 to December 2004, the technique of kissing balloon followed by T provisional stenting was applied for distal left main coronary lesion in 49 consecutive patients with PES stents.

CONCLUSION: Paclitaxel-eluting stent implantation for unprotected LMCA bifurcation narrowing appears safe with regard to acute and midterm complications and is more effective in preventing restenosis compared to BMS implantation.

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(PMID = 19755213.001).

[ISSN] 1774-024X

[Journal-full-title] EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology

[ISO-abbreviation] EuroIntervention

[Language] eng

[Publication-type] Journal Article

[Publication-country] France

58. Olivieri L, Arling B, Friberg M, Sable C: Coronary artery Z score regression equations and calculators derived from a large heterogeneous population of children undergoing echocardiography.J Am Soc Echocardiogr; 2009 Feb;22(2):159-64[Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Coronary artery Z score regression equations and calculators derived from a large heterogeneous population of children undergoing echocardiography.

BACKGROUND: Clinical decision making in Kawasaki disease relies on measurements of the coronary arteries obtained by 2-dimensional echocardiography.

Z scores relating measured values to independent variables are invaluable in ensuring the accurate and consistent treatment of patients with Kawasaki disease.

METHODS: The right coronary artery (RCA), left main coronary artery (LMCA), and left anterior descending (LAD) coronary artery were measured in 432 normal digital echocardiograms from a heterogeneous population of normal subjects aged 0 to 20 years.

OBJECTIVES: We performed the long-term follow-up of a large cohort of patients in a multicenter study receiving left main coronary artery (LMCA) revascularization.

METHODS: We evaluated 2,240 patients with unprotected LMCA disease who received coronary stents (n = 1,102; 318 with bare-metal stents and 784 with drug-eluting stents) or underwent CABG (n = 1,138) between 2000 and 2006 and for whom complete follow-up data were available for at least 3 to 9 years (median 5.2 years).

CONCLUSIONS: During 5-year follow-up, stenting showed similar rates of mortality and of the composite of death, Q-wave MI, or stroke but higher rates of TVR as compared with CABG for patients with unprotected LMCA disease.

MATERIALS AND METHODS: CT data of 700 patients who underwent 64-slice CT angiography (CTA) because of known or suspected coronary artery disease were retrospectively reviewed by two radiologists experienced in cardiovascular radiology.

RESULTS: The coronary artery system was right dominant in 76%, left dominant in 9.1% and co-dominant in 14.8% of the cases.

Conus artery with a separate ostium in the right sinus Valsalva was observed in 22%, and in 0.2% two conus arteries originating with separate ostia were visualized.

The sinus node artery (SNA) originated from the right coronary artery (RCA) in 79%, from the circumflex artery (Cx) in 20%, and from the left main coronary artery (LMCA) in 0.4%.

LMCA was absent in 0.4%.

High takeoff of LMCA and RCA were observed in 0.7% and 0.1%, respectively.

Anomalous origin of the coronary artery from the opposite sinus was observed in 1% of the cases.

CONCLUSION: Complex anatomy of the coronary artery system can accurately be depicted by 64-slice CTA.

This modality is useful in detecting coronary artery variants and anomalies and is a valid alternative to conventional coronary angiography in their diagnosis.

[Title] ["Needle-to-scalpel"--the benefit of urgent CABG in significant left main coronary artery stenosis].

Left main coronary artery (LMCA) stenosis is a relatively infrequent but important cause of symptomatic coronary artery disease.

The diagnosis of left main coronary artery disease is made by coronary angiography.

Coronary artery bypass grafting is the first-line therapy, the standard treatment for LMCA stenosis, which improves the likelihood of survival, while percutaneous coronary intervention (PCI) is emerging as a possible alternative to surgery.

We present the case of a patient with history and symptoms of stable angina pectoris, especially associated with exercise, variable threshold, since four years, and who describes a worsening of symptoms in the last month; the angina had become more frequent, more prolonged and occurred at a lower threshold.

This investigation showed severe left main coronary artery stenosis and significant lesions in other important vessels (three-vessel disease), in a patient with normal left ventricular function.

The recurrence and the intensity of prolonged angina of our patient have necessitated urgent myocardial revascularization surgery with quadruple coronary-artery bypass grafting.

CONCLUSIONS: The advantage of coronary artery bypass grafting performed as urgent surgery for the treatment of our patient with left main coronary artery stenosis and concomitant acute coronary syndrome, shortly after coronary angiography, was obvious, significantly improved the clinical outcome, without postoperative ischemic complications.

[Publication-country] Switzerland

65. Latsios G, Tsioufis K, Tousoulis D, Kallikazaros I, Stefanadis C: Common origin of both right and left coronary arteries from the right sinus of Valsalva.Int J Cardiol; 2008 Aug 18;128(2):e60-1[Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Common origin of both right and left coronary arteries from the right sinus of Valsalva.

Anomalous origin of the left main coronary artery (LMCA) from the right sinus of Valsalva (RSOV) represents in about 2 per 10,000 patients undergoing diagnostic cardiac catheterization.

We describe the case of a middle-aged woman, suffering from typical angina pectoris, with an anomalous common origin of all coronary arteries from the RSOV.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

Hemodynamically significant left main coronary artery stenosis (LMCA) is found in around 4% of diagnostic coronary angiograms and is known as unprotected LMCA stenosis if the left coronary artery and left circumflex artery has no previous patent grafts.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Late and very late stent thrombosis following drug-eluting stent implantation in unprotected left main coronary artery: a multicentre registry.

AIMS: To evaluate the occurrence of late and very late stent thrombosis (ST) following elective drug-eluting stent (DES) implantation in unprotected left main coronary artery (LMCA) stenosis in a large multicentre registry.

METHODS AND RESULTS: All 731 consecutive patients who had sirolimus- or paclitaxel-eluting stent electively implanted in de novo lesions on unprotected LMCA in five centres were included.

Four (0.5%) patients had a definite ST: three early (two acute and one subacute) and one late ST, no cases of very late definite ST were recorded.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Effectiveness of sirolimus-eluting stent implantation for the treatment of ostial left anterior descending artery stenosis with intravascular ultrasound guidance.

OBJECTIVES: This study was designed to evaluate the clinical and angiographic outcomes of sirolimus-eluting stent (SES) implantation for ostial left anterior descending (LAD) lesions compared with bare-metal stent (BMS) implantation.

In the SES group, for complete lesion coverage, stent positioning was intentionally extended into the distal left main coronary artery (LMCA) in 23 patients (34%) with intermediate LMCA narrowing.

In the SES group, there were no restenoses in cases with LMCA coverage, compared with three restenoses (7.9%) in cases with precise stent positioning (p = NS).

This finding may be associated with reduced neointimal hyperplasia and complete lesion coverage.

To determine if FLT3 might be involved more widely in BCR-ABL-negativeaCML, we analyzed 40 cases and found two were internal tandem duplication-positive, but D835 mutations were not observed.

CONCLUSION: Although FLT3 abnormalities are uncommon in aCML, SPTBN1-FLT3 is a novel constitutively active tyrosine kinase that appears to responsive to both targeted signal transduction therapy and immunotherapy.

71. Park SJ: Is stenting a preferred option for unprotected left main coronary artery disease in the drug-eluting stent era?Indian Heart J; 2007 Mar-Apr;59(2 Suppl B):B105-12[Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Is stenting a preferred option for unprotected left main coronary artery disease in the drug-eluting stent era?

Coronary artery bypass graft (CABG) has been the established treatment for left main coronary artery (LMCA) disease.

LMCA disease has been considered to be a challenge for interventional cardiologist for more than 25 years.

The early experience with drug-eluting stent (DES) in unprotected LMCA reveals reduced rates of restenosis and associated clinical outcomes when compared with patients who were treated with BMS.

However, up to now, effectiveness of DES is not enough to replace CABG in LMCA revascularization.

Based on these trials, it is likely that, for selected patients, DES may be regarded as a preferred revascularization strategy for LMCA disease.

The reconstructions were obtained in all cardiac phases at 50-millisecond intervals at a slice thickness of 0.75 mm and a reconstruction increment of 0.5 mm.

These included high take-off of the left main coronary artery (LMCA) (n=3, 0.3%), absence of the LMCA (n=3, 0.3%), coronary fistula (n=2, 0.2%), right-sided origin of the circumflex artery (n=2, 0.2%), and left anterior descending artery originating from the right coronary artery (n=1, 0.1%).

CONCLUSION: Multidetector computed tomography is a reliable and useful noninvasive method to identify and define anomalous coronary arteries and their course and can be used as the first-line diagnostic tool in the evaluation of CAAs.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] One-year outcomes of left main coronary artery stenting in patients with cardiogenic shock.

The aim of the study was to evaluate the outcomes of angioplasty and stenting in patients with cardiogenic shock caused by left main coronary artery (LMCA) disease.

METHODS: A group of 71 consecutive patients managed for LMCA disease in an emergency setting (38 patients in cardiogenic shock and 33 without shock symptoms) were followed up clinically and angiographically for one year.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

BACKGROUND: Improvements in results with percutaneous coronary intervention (PCI) with drug-eluting stents (DES) may extend their use in patients with left main coronary artery (LMCA) stenosis.

METHODS AND RESULTS: Two hundred forty-nine patients with LMCA stenosis were treated with PCI and DES implantation (n=107) or coronary artery bypass grafting (CABG) (n=142), in a single center, between March 2002 and July 2004.

At 1 year, there was no statistical difference in the occurrence of death in PCI versus CABG both for the unadjusted (OR=0.291; 95% CI=0.054 to 1.085; P=0.0710) and adjusted analyses (OR=0.331; 95% CI=0.055 to 1.404; P=0.1673).

CONCLUSIONS: At 1 year, in this single-center, retrospective experience, there was no difference in the degree of protection against death, stroke, myocardial infarction, and revascularization between PCI with DES and CABG for LMCA disease.

(PMID = 16717151.001).

[ISSN] 1524-4539

[Journal-full-title] Circulation

[ISO-abbreviation] Circulation

[Language] eng

[Publication-type] Comparative Study; Journal Article

[Publication-country] United States

[Chemical-registry-number] 0 / Pharmaceutical Preparations

76. Tommaso CL: PCI for LMCA stenosis--is it time to ride the rank bull?Catheter Cardiovasc Interv; 2006 Sep;68(3):363-4[Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

Because of the long-term benefit of coronary artery bypass graft (CABG) surgery in medical therapy, CABG has been the standard treatment of unprotected left main coronary artery (LMCA) stenosis.

However, with the advancement of techniques and equipment, the percutaneous interventional approach for implantation of coronary stents has been shown to be feasible for patients with unprotected LMCA stenosis.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Percutaneous coronary intervention versus coronary artery bypass graft surgery for the treatment of unprotected left main coronary artery stenosis: in-hospital and one year outcome after emergent and elective treatments.

This study attempts to compare the risks and benefits of provisional stenting with drug eluting stents and bypass surgery for left main coronary artery (LMCA) stenosis.

However, application of percutaneous techniques to LMCA has been sporadic and controversial.

In-hospital and one year outcomes of coronary artery bypass graft (CABG) and percutaneous coronary intervention (PCI) cases were compared.

From September, 2003 to June, 2005, a total of 59 consecutive patients with de novo unprotected LMCA stenosis were treated with either CABG or PCI.

Twenty patients received non-intravascular ultrasound-guided PCI with a stent in the LMCA.

At 30-day follow-up, the major adverse cardiac and cerebrovascular event (MACE) rates of mortality, myocardial infarction, cerebral vascular accident, and target vessel revascularization were 25.6% in the CABG group and 5% in the PCI group (P=0.054).

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Percutaneous intervention of left main coronary artery compression by pulmonary artery aneurysm.

BACKGROUND: Extrinsic compression of the left main coronary artery (LMCA) by a pulmonary artery aneurysm (PAA) has become increasingly recognized as an etiology of angina in patients with pulmonary arterial hypertension (PAH).

The purpose of this study was to assess the feasibility and efficacy of LMCA stenting in the treatment LMCA stenosis because of PAA.

METHODS: Retrospective analysis of data on patients with PAH who presented with angina and underwent percutaneous intervention of their LMCA compression because of PAA was performed.

RESULTS: Five patients (age 51 ± 16 years, all female) with PAH presented with angina and underwent LMCA stenting between 2007 and 2009.

LMCA compression because of a PAA was diagnosed in all patients with cardiac CT angiography after echocardiography demonstrated an enlarged pulmonary artery.

LMCA stenting was successfully performed in all patients with resolution of angina and electrocardiographic abnormalities.

CONCLUSIONS: LMCA stenting appears to be a feasible and durable option in patients who present with angina because of compression by PAA.

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(PMID = 20552652.001).

[ISSN] 1522-726X

[Journal-full-title] Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions

[ISO-abbreviation] Catheter Cardiovasc Interv

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

82. Murasato Y: Impact of three-dimensional characteristics of the left main coronary artery bifurcation on outcome of crush stenting.Catheter Cardiovasc Interv; 2007 Feb 1;69(2):248-56[Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Impact of three-dimensional characteristics of the left main coronary artery bifurcation on outcome of crush stenting.

BACKGROUND: Crush stenting with drug-eluting stents is used to treat left main coronary artery (LMCA) bifurcations.

However, the rate of restenosis at the left circumflex (LCX) artery ostium is high.

The impact of the three-dimensional (3D) structure of LMCA bifurcation on the outcome of crush stenting with respect to restenosis has not been described.

METHODS: Bare metal stents were crushed at LMCA bifurcations in a 3D model that reproduced actual angles, such that the stent deployed from the LMCA to the left anterior descending (LAD) artery crushed the stent deployed from the LMCA to the LCX, followed by kissing balloon inflation.

RESULTS: In the 3D model, one stent overlapped the other in the distal LMCA, in contrast to the nearly parallel position of the stents observed in a separate two-dimensional model.

A narrow LMCA-LCX angle was associated with less expansion of the LCX stent at the ostium than more distally, and with a higher likelihood of incomplete stent apposition.

CONCLUSIONS: Overlap of the LAD stent over, as opposed to under, the LCX stent was associated with close apposition of the stent to the vessel on the myocardial side, at the ostium of the LCX artery, where atherosclerotic plaques are likely to be present.

The spatial plaque burden and bifurcation angle should be closely examined before crush stenting, and segments should not be left unstented over large plaques.

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[Copyright] (c) 2006 Wiley-Liss, Inc.

(PMID = 17211894.001).

[ISSN] 1522-1946

[Journal-full-title] Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions

(PMID = 18925974.001).

[ISSN] 1475-925X

[Journal-full-title] Biomedical engineering online

[ISO-abbreviation] Biomed Eng Online

[Language] eng

[Publication-type] Journal Article

[Publication-country] England

[Chemical-registry-number] 0 / Lipoproteins, LDL

[Other-IDs] NLM/ PMC2615017

86. Park SJ, Park DW: Left main stenting: is it a different animal?EuroIntervention; 2010 Dec;6 Suppl J:J112-7[Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title]Left main stenting: is it a different animal?

For several decades, coronary-artery bypass grafting (CABG) has been regarded as the treatment of choice for patients with unprotected left main coronary artery (LMCA) disease.

However, because of marked advancements in techniques of percutaneous coronary intervention (PCI) with stenting and CABG, as well as adjunctive pharmacologic therapy, a new evaluation and review of current indications for optimal revascularisation therapy for LMCA disease may be required to determine the standard of care for these patients.

The available current evidence suggests that the composite outcome of death, myocardial infarction and stroke is similar in patients with LMCA disease who are treated with PCI with stenting or CABG, the only difference was the rate of repeat revascularisation.

The molecular pathogenesis of aCML and its relationship to other myeloproliferative neoplasms is unknown.

None of the nine amplifiable cases of aCML and none of the normal BM controls showed a JAK2 V617F mutation, in contrast to 45/59 (76%) of the Phchromosome negative CMPN cases.

AtypicalCML should therefore be considered as a JAK2 negative chronic myeloid neoplasm that remains properly categorized, alongside chronic myelomonocytic leukemia and juvenile myelomonocytic leukemia, within the WHO group of myelodysplastic/myeloproliferative neoplasms.

[Language] eng

[Publication-type] Journal Article

[Publication-country] England

88. Macdonald D, Cross NC: Chronic myeloproliferative disorders: the role of tyrosine kinases in pathogenesis, diagnosis and therapy.Pathobiology; 2007;74(2):81-8[Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title]Chronic myeloproliferative disorders: the role of tyrosine kinases in pathogenesis, diagnosis and therapy.

The term chronic myeloproliferative disorders was originally used by Damashek to describe the link amongst a group of acquired blood diseases.

These may be chromosomal translocations resulting in the creation of a fusion kinase gene, examples of which include ABL, FGFR, and PDGFR as seen in disorders CML, 8p11 myeloproliferative syndrome, atypicalCML and chronic eosinophilic leukaemia.

This abnormality is seen in 30-97% of cases of MPD with the phenotype PV, ET or CIMF.

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(PMID = 19008593.001).

[ISSN] 0377-4929

[Journal-full-title] Indian journal of pathology & microbiology

[ISO-abbreviation] Indian J Pathol Microbiol

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] India

[Chemical-registry-number] 0 / Chromatin

90. de Man K, Patterson M, Kiemeneij F: Bifurcation balloon for left main shock syndrome: facilitating the simultaneous percutaneous reperfusion of the LAD and circumflex.J Invasive Cardiol; 2006 Nov;18(11):E270-2[Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Bifurcation balloon for left main shock syndrome: facilitating the simultaneous percutaneous reperfusion of the LAD and circumflex.

Acute occlusion of the left main coronary artery frequently causes cardiogenic shock and, when this occurs with an initial TIMI 0 flow, has an extremely poor prognosis.

This case describes a distal LMCA occlusion, 2 weeks post-stenting of the proximal LAD and proximal Cx, where this strategy was successfully used as a bridge to surgery.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Intravascular ultrasound-based left main coronary artery assessment: comparison between pullback from left anterior descending and circumflex arteries.

OBJECTIVE: We compared continuous pullback from the left anterior descending artery (LAD) with pullback from the circumflex artery (CX) for the assessment of the left main coronary artery (LMCA) by intravascular ultrasound (IVUS).

BACKGROUND: Gray-scale IVUS and virtual histology by IVUS (IVUS-VH) overcome many shortcomings of contrast angiography in diagnostic assessment of the LMCA.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Angina associated with left main coronary artery compression in pulmonary hypertension.

Left main coronary artery (LMCA) compression by an enlarged pulmonary artery trunk (PAT) has been associated with angina, but appropriate diagnostic and treatment approaches remain poorly defined.

We present two cases of angina caused by LMCA compression from an enlarged pulmonary artery, one of which also presented with new, severe left ventricular systolic dysfunction attributed to myocardial ischemia.

Diagnosis of LMCA stenosis was made via coronary angiography followed by computed tomography-gated coronary angiography (CT-CA), which confirmed pulmonary artery enlargement as the source of extrinsic compression.

Restoring LMCA patency with percutaneous intervention and/or aggressive treatment of pulmonary hypertension led to significant improvement in angina, cardiac function and quality of life.

Given the negative impact on cardiac function, prompt diagnosis and treatment of extrinsic LMCA compression should be considered a priority.

[Publication-country] United States

94. Jönsson A, Hammar N, Nordquist T, Ivert T: Left main coronary artery stenosis no longer a risk factor for early and late death after coronary artery bypass surgery--an experience covering three decades.Eur J Cardiothorac Surg; 2006 Aug;30(2):311-7[Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title]Left main coronary artery stenosis no longer a risk factor for early and late death after coronary artery bypass surgery--an experience covering three decades.

OBJECTIVE: To analyse early and late mortality after coronary artery bypass grafting (CABG) in patients with and without left main coronary artery (LMCA) stenosis during the 30-year period 1970-1999.

METHODS: A total of 1888 of 10,647 patients (18%) who underwent a first isolated CABG at the Karolinska Hospital in Stockholm, Sweden, during 1970-1999 had significant left main coronary artery stenosis.

RESULTS: The proportion of patients with LMCA stenosis of all CABG patients increased from 7% during the 1970s to 26% in 1999.

The aim of the study was to assess the value of lead aVR and V1 on the exercise electrocardiogram for the detection of left main coronary artery stenosis (LMCAS) and its equivalent (LMCASE) in patients with chronic stable angina pectoris and the strongly positive EET result.

In patients with isolated exercise-induced ST elevation in lead aVR, the prevalence of LMCAS was five times more frequent than in patients without lead aVR ST elevation (25.8% vs 4.8% p<0.05).

There were no differences in the prevalence of LMCASE and multi-vessel coronary disease in the studied groups.

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(PMID = 16789487.001).

[Journal-full-title] Polskie Archiwum Medycyny Wewnetrznej

[ISO-abbreviation] Pol. Arch. Med. Wewn.

[Language] pol

[Publication-type] English Abstract; Journal Article

[Publication-country] Poland

96. Ionescu CN, Donohue TJ: ECG findings in acute left main coronary artery thrombosis: a case report and review of the literature.Conn Med; 2009 Jun-Jul;73(6):333-5[Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] ECG findings in acute left main coronary artery thrombosis: a case report and review of the literature.

Acute coronary syndrome due to left main coronary artery (LMCA) thrombosis is a catastrophic event associated with poor prognosis and high in-hospital mortality.

Unfortunately, the electrocardiographic manifestations of LMCA thrombosis are nonspecific.

This report describes the electrocardiogram (ECG) findings in a patient with LMCA thrombosis.

A new right bundle branch block (RBBB) pattern, especially when associated with ST elevation in aVR and V1, should raise suspicion of this diagnosis.

From May 1997 to March 2003 all patients in 23 hospitals undergone elective unprotected LMCA stenting with bare metal stents were enrolled into the registry.

Mean left ventricular EF was 63.9% +/- 12.3%.

Stents were successfully implanted into LMCA in 223 cases (99.6%) and into non-LMCA in 91 cases (92.9%).

Death developed in 12 cases (5.4%), including cardiac death in 10 cases (4.5%) and non-cardiac death in 2 cases (0.9%), MI in 4 cases (1.8%), TLR of LMCA in 26 cases (11.7%) and accumulated MACE in 36 cases (16.1%).

CONCLUSION: Stenting for selected patients with unprotected LMCA stenosis is feasible and safe.

Currently, unprotected LMCA stenting should be performed in patients with LVEF >or= 40% and isolated LMCA disease or LMCA combined with multivessel diseases in whom complete revascularization could be obtained or inoperable patients.

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MIDCAB procedure for grafting of the left intramammary artery (LIMA) with the left anterior descending (LAD) artery was first performed via lower partial ministernotomy on the beating heart, followed by PCI on the LMCA disease and non-LAD coronary lesions.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

RESULTS: A total of 15 consecutive patients undergoing percutaneous coronary intervention with DES in de novo trifurcation lesions were identified.

Lesions were located as follows: 13 (86.7%) at the distal left main coronary artery (LMCA) comprising the left anterior descending artery (LAD), the left circumflex artery (LCX) and an intermediate branch; 1 between the LAD, diagonal, and septal branches; and 1 between the LCX, obtuse marginal and posterior lateral branches.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] How good are experienced interventional cardiologists at predicting the functional significance of intermediate or equivocal left main coronary artery stenoses?

In patients with intermediate left main stem lesions clinical decision making based on FFR is safe and feasible.

This study was performed to assess the accuracy of visual angiographic assessment of intermediate or equivocal left main coronary artery (LMCA) stenoses by experienced interventional cardiologists when taking fractional flow reserve (FFR) measurements as the gold standard.