CBG Faculty

The causes of most human cancers are unclear, but appear to be related to miscues in normal tissue developmental pathways, mutations (genetic and epigenetic) in critical genes caused by errors, infection, and chemicals, and a failure of recognition and removal of tumors by the immune system. Dr. Wiemels studies these factors as potential causes of hematopoietic and brain tumors. Large population-based studies of human cancer in California populations form a basis for examining the origin of these cancers, with a focus on future prevention. This type of research is highly collaborative, and Dr. Wiemels works with several epidemiologists, geneticists, clinicians, biologists, and statisticians.

Association of genetic variation in IKZF1, ARID5B, and CEBPE and surrogates for early-life infections with the risk of acute lymphoblastic leukemia in Hispanic children Cancer Causes Control. 2015 Apr; 26(4):609-19. . View in PubMed