If you plan to use the 2TB as a entire drive your going to be stuck to a few OSs that will support it because the only way to properly be able to use a 2TB drive is with an OS that can read GPT tables as MBR will no longer work.

Any system that I would put a drive like this in it, use already uses an OS that would support it, no issue.

All recent modern OSs(Mac OSX, Windows, Linux) I can think of, all support GPT tables.