The core members are the 22 Ministries and Departments of Health in the Pacific Island countries and territories, who endorsed the network and its function, and whose authority or consensus guides its work.

The network is further supported by allied bodies — regional and international agencies, training institutions, laboratories, and other partners who can supplement the network with technical expertise, and in-kind and financial support.

A Coordinating Body(CB) is drawn from each of these two groups, and consists of 7 core and 5 allied body members. The CB membership is rotated in a staggered manner, with membership voted or endorsed by network and CB members.