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The Institute is located in the Staszic Palace in the center of Warsaw, near the Copernicus monument. Among its founders were professors: Bogdan Suchodolski and Aleksander Birkenmajer. In the mid 1970s, it was renamed to the Institute for the History of Science, Education and Technology. Since 1994, the name has been shortened to the Institute for the History of Science, but with its previous research scope. The head of its present Academic Council is Andrzej Kajetan Wróblewski. Since 2011 the Institute has taken the official name of Ludwik Birkenmajer and Aleksander Birkenmajer: L & A Birkenmajer Institute for the History of Science (Polish: Instytut Historii Nauki PAN imienia Ludwika i Aleksandra Birkenmajerów).

The Institute consists of two departments: the Department of the History of Social Sciences, History of Education and Scholarly Institutions (Sections: History of Social Sciences, History of Education, History of Scientific Organizations), and the Department of the History of Exact Sciences, Natural Sciences and Technology (Sections: History of Exact Sciences and Technology, History of Medicine, History of Chemistry and Pharmacy, History of Mathematics).