"A persistent NLR >3 during treatment with enzalutamide seems to have both A persistent NLR >3 during treatment with enzalutamide seems to have both prognostic and predictive value in CRPC patients. value in CRPC patients."

It's all very well to write about "prognostic and predictive value", but inflammation can be reversed.

There are now 45 PubMed hits for <prostate Neutrophil Lymphocyte Ratio>, but are doctors paying attention?

The most recent Review and Meta-Analysis came out in April [2]:

"The present meta-analysis indicated that the inflammation marker NLR had prognostic values for OS {overall survival } and RFS {recurrence-free survival} in patients with PCa. Although high pretreatment NLR had a significant prognostic value in patients with advanced PCa, such NLR had no predictive value in terms of OS in patients with localized PCa. Therefore, higher pretreatment NLR had a stronger predictive effect in patients with more advanced disease. In terms of RFS, patients with higher pretreatment NLR had shorter RFS than those with lower NLR in both localized and advanced PCa; however, the association was more significant in patients with advanced PCa. Two previous studies in patients with colorectal and lung cancers also concluded that the prognostic value of NLR was higher in more advanced cancers"

Basically, any plant polyphenol with a PCa literature showing, should be considered. Curcumin, apigenin, resveratrol, pomegranate & a dozen other common phytochemicals are contenders. Use a mix & back into a dose that shows results. (Don't use a-Lipoic acid.)

Other inflammation markers to monitor:

- albumin - should be >=4.5

- C-Reactive Protein - should be as close to zero as possible. Most of the reference range is too high