Abstract

The prospective study was conducted on women in a tertiary care centre to determine the incidence of
Human papilloma virus genome in women with cervical neoplasiaand to correlate the available risk
factors for HPV infection and cervical cancer.Cervical smears were taken and graded according to
Bethesda system.Women who had Pap smear suggestive of CIN either underwent colposcopy and guided
biopsy or 4 quadrant biopsy. Women who had a frank growth underwent cervical biopsy. A cervical swab
was also taken from the ectocervix and endocervix which were kept in a sterile container and stored at -
4°C. Patients with histological confirmation of CIN (Cervical intraepithelial neoplasia) / ICC (Invasive
cervical cancer) were taken as cases and subjected to HPV DNA study. Incidence of HPV positivity
among cases was 38.23% with an odds ratio of 21.66. All HPV positive women were infected with a
single virus. The most commonvirus identified was HPV 16 with incidence of 32.35%.High parity, low
economic status and illiteracy were a significant risk factor in causing infection & cervical neoplasm.