Imodium General Information

One of the long-acting synthetic antidiarrheals; it is not significantly absorbed from the gut, and has no effect on the adrenergic system or central nervous system, but may antagonize histamine and interfere with acetylcholine release locally. .[PubChem].

Imodium - Pharmacology:

In vitro and animal studies show that Imodium acts by slowing intestinal motility and by affecting water and electrolyte movement through the bowel. Imodium inhibits peristaltic activity by a direct effect on the circular and longitudinal muscles of the intestinal wall. It is a non-selective calcium channel blocker and binds to opioid mu-receptors. Evidence also suggests that at higher concentrations it binds to NMDA receptors and to calmodulin.