Conditions: Renal Insufficiency, Chronic; ObesityIntervention: Sponsors: The Cleveland Clinic; University of Pennsylvania; Case Western Reserve University; University of Michigan; University of Illinois at Chicago; University of Maryland; MetroHealth Medical CenterRecruiting - verified July 2015

Conditions: Diabetic Nephropathies; Coronary Artery DiseaseInterventions: Drug: Allopurinol; Drug: PlaceboSponsors: Alessandro Doria; National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); Juvenile Diabetes Research Foundation; Joslin Diabetes Center; University of Minnesota - Clinical and Translational Science Institute; University of Colorado, Denver; University of Michigan; University of Toronto; Feinberg School of Medicine, Northwestern University; Albert Einstein College of Medicine of Yeshiva University; Steno Diabetes Center; Washington University School of Medicine; University of Washington; Emory University; University of Calgary; University of Alberta; University of Texas Southwestern Medical CenterRecruiting - verified May 2015