Experimental Ebola drug helped critically ill doctor – study

An anti-Ebola prototype drug has helped a critically ill doctor from Sierra Leone, according to the latest study. The medic, who was flown to a German hospital in September with severe Ebola symptoms and discharged a month later, fully recovered.

The study, published in medical journal The
Lancet, has urged clinical evaluation of the treatment.

The 38-year-old doctor was airlifted and transferred to Frankfurt
University Hospital in September, showing vascular leakage and
failure of several organs.

“In view of the urgency for action in light of the current
epidemic, where validated therapies are desperately needed, the
efficacy of FX06 should soon be assessed in clinical trials or at
least by standardized collection of data from patients with Ebola
virus disease who received it in a compassionate use
setting,” the patient’s medics wrote in The Lancet.

After antibiotics and a three-day course of a test drug FX06 –
only clinically tested to work on mice – the patient demonstrated
drastic improvement. He was released after a 30-day observation
period, with no Ebola material in his blood plasma, the doctors
said in a statement.

“Even though the patient was critically ill, we were able to
support him long enough for his body to start antibody production
and for the virus to be cleared by his body’s defenses,”
said Dr. Timo Wolf, who led the study.

Additionally to the drug, intravenous fluids, mechanical
ventilation and procedures to treat kidney failure, including
dialysis, were used.

During the treatment, doctors noted that the medicine supported
the patient until he could begin to produce antibodies against
the deadly virus that has already led to 7,000 deaths.

FX06, developed at Vienna General Hospital, may help repair the
walls of a patient’s blood vessels, keeping the person alive long
enough to develop antibodies to battle the virus, Petra Wülfroth,
acting chief operating officer of the drug’s developer, said in a
telephone interview with Bloomberg.

There is no proven cure or vaccine for Ebola. A number of
potential vaccines and drugs have been developed but none of them
have been through all clinical tests.