Please use this identifier to cite or link to this item :http://hdl.handle.net/2066/90603

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Subject:

Action, intention, and motor controlDI-BCB_DCC_Theme 2: Perception, Action and Control

Organization:

FSW_Fac. algemeenSW OZ DCC CO

Journal title:

Cognitive Neuroscience

Volume:

vol. 1

Issue:

iss. 2

Page start:

p. 111

Page end:

p. 117

Abstract:

Core psychopathological symptoms in patients with schizophrenia suggest that their sense of self may be disturbed. A disturbance in predictive motor mechanisms may be the cause of such symptoms. Ten patients with schizophrenia and ten healthy right-handed control subjects opened and closed their hand. This movement was filmed with an MRI compatible video camera and projected online onto a monitor. BOLD contrast was measured with fMRI. The temporal delay between movement and feedback was parametrically varied. Participants judged whether or not there was a delay. Patients were less sensitive to these delays than a matched control group. Comparing neural activation between the two groups showed a reduced attenuation of movement-sensitive perceptual areas in patients with increasing delay and a higher activation in the putamen in controls. The results provide further evidence that impaired efference copy mechanisms may contribute to the pathogenesis of schizophrenia and its first rank symptoms.