Natriuretic propeptide levels and echocardiographic parameters in patients with acromegaly

Background. Cardiovascular disease is the major cause of high mortality in patients with acromegaly. Aim. Evaluating echoCG parameters in patients with acromegaly depending on pro-ANP and pro-BNP levels. Materials and methods. 46 acromegalic patients aged 40 to 73 years with the disease duration of 5 to 28 years were examined. EchoCG data and pro-ANP and pro-BNP levels were analyzed. Results. In patients with acromegaly, the level of pro-BNP was significantly increased in both active phase and remission. LV cavity hypertrophy and LV dilation were observed in patients both with normal and increased pro-ANP and pro-BNP levels. Significant decreases in EF, SF, and VE / VA ratio were observed in all acromegalic patients irrespective of natriuretic peptide levels, compared to the control group. Conclusion. In acromegaly, a direct interrelation was observed between pro-peptide levels, primarily pro-BNР, and SAD and LV hypertrophy severity. Diastolic dysfunction associated with sufficient myocardial contractility was found in all acromegalic patients irrespective of pro-BNP and pro-ANP levels.