NR1I3 Genes

NR1I3

nuclear receptor subfamily 1 group I member 3

This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

SNP Genotyping Assays

Search all TaqMan® SNP Genotyping Assays,
including Drug Metabolism Genotyping Assays, and assays that are
functionally tested or validated.

Drug Metabolism Assays

Drug Metabolism Assays

These assays are specifically
designed to detect polymorphisms in 221 genes that code for
various drug metabolism enzymes and drug transporters. Assays are
tested using gDNA from 45 individuals from four ethnicities. The
minor allele frequency for each population is available, but rare
and mutant alleles may not be present in the test DNA.

Which Copy Number product(s) are you interested in using?

All Copy Number Assays

All Copy Number Assays

Search all TaqMan® Copy Number Assays and required
TaqMan® Copy Number Reference Assays.

Markers & Reporters

Markers & Reporters

Marker & Reporter assays are
designed to detect the copy number of marker and reporter genes
from expression vectors that have been introduced into cells or
animals, such as the lacZ reporter gene or antibiotic genes.

Recommended Use: Animal experiments

Ambion® In Vivo siRNAs are designed using the Silencer®
Select algorithm and incorporate chemical modifications that help
provide superior serum stability for in vivo delivery.

Stealth RNAi™ siRNA

Recommended Use: Continuity in cell culture and animal experiments

Stealth RNAi siRNAs uses their
proprietary chemical modifications for restricting off-target
effects and their effective algorithm for providing efficient
knockdown. They are recommended for completing in vitro RNAi
studies that were started using Stealth siRNAs. For new studies,
we recommend Ambion Silencer Select siRNAs.

Unmodified siRNA

Recommended Use: Continuity in cell culture experiments

Silencer® siRNAs are designed using our
first-generation algorithm and do not include any chemical
modifications. They are recommended for completing in
vitro RNAi studies that were started using Silencer®
siRNA. For new studies, we recommend Silencer®
Select siRNAs.

Primary MicroRNA Assays

Mimics

Small, synthetic, double-stranded RNA molecules designed to mimic
endogenous mature miRNAs. They are supplied ready-to-use; they
can be introduced into cells using transfection or
electroporation. We recommend mirVana™
miRNA Mimics, but we continue to offer Ambion®
Pre-miR miRNA Precursors for completion of studies that were
started using these first-generation products.

Inhibitors

Small, synthetic, single-stranded RNA molecules designed to
specifically bind to and inhibit mature miRNAs from functioning.
We recommend mirVana™ miRNA inhibitors,
but we continue to offer Ambion® Anti-miR™
miRNA Inhibitors for completion of studies that were started
using these first-generation products.

96-well Fast

384-well

Sets of pre-selected TaqMan® Gene Expression assays
for specific pathways, biomarker sets, or disease states in
384-well microfluidic card format. A TaqMan® Array
block, available for our 7900HT, Viia7™ and
QuantStudio™ 12K Flex systems, is required for
these arrays.

OpenArray

OpenArray

Sets of pre-selected TaqMan® Gene Expression assays
for specific pathways, biomarker sets, or disease states in
OpenArray™ format. A QuantStudio™
12K Flex or NT Cycler system is required for these arrays.

What type of Antibodies are you interested in?

Primary

Primary Antibodies

Thermo Fisher Scientific offers a large portfolio of primary antibodies against key signaling proteins, cellular markers and organelles as well as cell junctions and CD markers.

Secondary

Secondary Antibodies

Thermo Fisher Scientific has thousands of secondary antibodies and their conjugates including Alexa Fluor, DyLight, HRP and Qdot for immunoassay development.

LentiArray™ sgRNAs

LentiArray™ sgRNA are sgRNAs pre-packaged as ready to use lentiviral particles. LentiArray™ sgRNAs provide the versatility to apply CRISPR based editing to a wide variety cell lines including hard to transfect cell lines.

Software reporting coordinates should report the reference version in the same file in the file header.The name of the v38 reference in files, content, and APIs produced by all Thermo Fisher software shall be GRCh38.p2
unless required otherwise by some overriding public spec.
The name of the previous version shall be hg19, for compatibility with current files: e.g. ##Assembly=hg19.

*If you enter a microarray probe ID, your search will return the 3' most assay(s) for the corresponding gene

Assay IDs

Entrez Gene IDs

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RefSeq Accession numbers

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Protein IDs

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Array Probe IDs

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siRNA IDs

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Protein IDs

RNAdb IDs and Gene Symbols

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UniGene ID

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Nucleotide Mutation (c.2582T>A)

Amino Acid Change (p.L861Q)

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RefSeq Accessions

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Plate SKU

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Assay ID

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sgRNA IDs

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OR

Option 2: Upload Keywords

The following file types are supported: ANSI files with
extension .txt, .txtN (where N is a number) or .vcf containing
either a list of keywords, the exported results from a previous
assay search, or VCF-compliant data.