Gatekeepers and progenitor cells in preneoplastic lesions and very early HCC

Various sources

High-grade dysplastic nodules are pre-neoplastic lesions in cirrhotic patients. Different studies indicate that 30% of them degenerate over time. This project will try to determine the primordial molecular changes during this transformation by analyzing a set of high-grade dysplastic nodules and early HCC. Analysis will also include their evaluation as potential niches of cancer stem cells.