..We have previously demonstrated that inhibition of dipeptidyl peptidase (DP) activity partially attenuates dextran sulfate sodium (DSS) colitis in mice. The aim of this study was to further investigate the mechanisms of this protection...

Development and resolution of experimental colitis in mice with targeted deletion of dipeptidyl peptidase IV

..05). We conclude that L. fermentum BR11 has the potential to reduce inflammation of the upper small intestine. However, its combination with FOS does not appear to confer any further therapeutic benefit for the alleviation of mucositis...

A small-scale, low-cost isolation system for the incubation and rearing of low bacterial load chicks as a model to study microbial-intestinal interactions

..Despite the presence of bacterial species, the isolator system was successful in producing low bacterial load chicks for comparison studies with conventionally raised chicks...

Mucositis and non-invasive markers of small intestinal function

Katie L TooleyCentre for Paediatric and Adolescent Gastroenterology, Children, Youth and Women s Health Service and Discipline of Physiology, University of Adelaide, 72 King William Road, North Adelaide, SA, AustraliaCancer Biol Ther 8:753-8. 2009

..We propose the SBT a superior biomarker of small intestinal function that could be successfully applied in clinical practice for monitoring the development of mucositis in cancer patients undergoing chemotherapy...

Effects of etoposide and cyclophosphamide acute chemotherapy on growth plate and metaphyseal bone in rats

..Bb12 had minimal effects, whilst TH-4 did not prevent DSS-colitis and LGG actually exacerbated some indicators of colitis. Further studies into the potential benefits of L. fermentum BR11 are indicated...

Effects of TGF-alpha gene knockout on epithelial cell kinetics and repair of methotrexate-induced damage in mouse small intestine

Gordon S HowarthChild Health Research Institute and Gastroenterology Department, Women s and Children s Hospital, and Disciplines of Physiology and Paediatrics, University of Adelaide, Adelaide, South AustraliaJ Nutr 133:2109-12. 2003

..These results suggest an intervention strategy based on the blockade of the B7-costimulatory axis could find application in the treatment of inflammatory bowel disease...

Bacterial modulation of small intestinal goblet cells and mucin composition during early posthatch development of poultry

R E A ForderDiscipline of Agricultural and Animal Science, School of Agriculture, Food and Wine, University of Adelaide, Roseworthy, 5371, South AustraliaPoult Sci 86:2396-403. 2007

..04 +/- 0.02 x10(3) cells/mm(2)). This change in mucin profile in response to bacterial colonization suggests a potential role as a protective mechanism against pathogenic invasion of the intestinal mucosa during early development...

..Zn induces metallothionein (MT) which has been shown to sequester free radicals. The aim of this study was to determine the capacity for dietary Zn supplementation to ameliorate methotrexate (MTX)-induced intestinal mucositis...

A novel breath test for the non-invasive assessment of small intestinal mucosal injury following methotrexate administration in the rat

..Zn partially prevented the distal colon of MT+/+ by 47% from DSS-induced damage compared to MT-/- mice. MT did not prevent DSS-induced colitis and Zn was partially effective in amelioration of DSS-induced colitis...

..Crypt hyperplasia (p<0.05) was observed in the saline group compared to P32/98 treatment at day 9. This preliminary study shows that novel inhibitors of DP activity may provide a new treatment strategy for IBD...

Small-intestinal manifestations of dextran sulfate sodium consumption in rats and assessment of the effects of Lactobacillus fermentum BR11

..Ussing chambers are commonly utilized for in vitro investigations into gastrointestinal permeability. However, their sensitivity and applicability to the small intestine have not been well characterized...

Effects of insulin-like growth factor-I and its analogue, long-R3-IGF-I, on intestinal absorption of 3-O-methyl-D-glucose are less pronounced than gut mucosal growth responses

..Long-R3-IGF-I, but not native IGF-I, enhanced 3MG absorption from the intestinal lumen, presumably reflecting an increased mucosal mass rather than an up-regulation of specific epithelial glucose transporters...

..Moreover, we hypothesize that the short-chain fatty acid, butyrate, will induce apoptosis in gastric cancer cells and, secondly, that differences in butyrate metabolism will exist between these cancer cell lines...