Summariesfor KCNN3 gene

Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for

several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the

AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. This gene belongs

to the KCNN family of potassium channels. It encodes an integral membrane protein that forms a

voltage-independent calcium-activated channel, which is thought to regulate neuronal excitability by contributing

to the slow component of synaptic AHP. This gene contains two CAG repeat regions in the coding sequence. It was

thought that expansion of one or both of these repeats could lead to an increased susceptibility to schizophrenia

or bipolar disorder, but studies indicate that this is probably not the case. Alternatively spliced transcript

variants encoding different isoforms have been found for this gene. (provided by RefSeq, Feb 2011)

GeneCards Summary for KCNN3 Gene:

KCNN3 (potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3) is a protein-coding gene. Diseases associated with KCNN3 include bipolar disorder, and schizophrenia. GO annotations related to this gene include small conductance calcium-activated potassium channel activity and calmodulin binding. An important paralog of this gene is KCNN4.

Subunit: Heterooligomer. The complex is composed of 4 channel subunits each of which binds to a calmodulin subunit

which regulates the channel activity through calcium-binding (By similarity)

Secondary accessions: B1ANX0 O43517 Q86VF9 Q8WXG7

Alternative splicing: 3 isoforms: Q9UGI6-1Q9UGI6-2Q9UGI6-3 (Do not produce functional channels, but selectively suppresses endogenous SK3 currents, in a dominant-negative fashion. This dominant inhibitory effect extends to other members of the SK subfamily. Widely distributed in human tissues and is present at 20-60% of SK3 in the brain)

Explore the universe of human proteins at neXtProt for KCNN3: NX_Q9UGI6