The homeoprotein Engrailed is not only a survival factor for mesencephalic dopaminergic (mDA) neurons during development, but continues to exert neuroprotective and physiological functions in adult mDA neurons. [Review]

Human Engrailed Homeobox 1 (EN1) interaction partners

low-frequency non-coding variant near a novel locus, EN1, with an effect on bone mineral density--which was also associated with a decreased risk of fracture

EN1 is an activator of intrinsic inflammatory pathways associated with prosurvival in basal-like breast cancer.

The current review describes the role of two such factors, Nurr1 and engrailed, in differentiation, maturation, and in normal physiological functions including acquisition of neurotransmitter identity.

EN1 is a biologic predictor of poor prognosis in patients with salivary adenoid cystic carcinoma.

Engrailed Homeobox 1 (EN1) Antigen Profile

Antigen Summary

Homeobox-containing genes are thought to have a role in controlling development. In Drosophila, the 'engrailed' (en) gene plays an important role during development in segmentation, where it is required for the formation of posterior compartments. Different mutations in the mouse homologs, En1 and En2, produced different developmental defects that frequently are lethal. The human engrailed homologs 1 and 2 encode homeodomain-containing proteins and have been implicated in the control of pattern formation during development of the central nervous system.