Catalyzes the NAD(P)(+)-dependent oxidation of D-glucose to D-gluconate via gluconolactone. Is also significantly active with D-galactose as substrate, but not with D-xylose, L-arabinose, D-ribose, D-mannose, D-allose, D-glucosamine, 2-deoxy-D-glucose, or glucose-6-phosphate. Can utilize both NAD(+) and NADP(+) as electron acceptor, with a marked preference for NADP(+) (20-fold higher activity). Physiologically, may be involved in the degradation of both glucose and galactose through a non-phosphorylative variant of the Entner-Doudoroff pathway.

Also known as Glucose/galactose 1-dehydrogenase (Galactose 1-dehydrogenase [NADP(+)]) (Glucose 1-dehydrogenase 2) (GDH 2) (GlcDH 2).Catalyzes the NAD(P)+-dependent oxidation of D-glucose to D-gluconate via gluconolactone. Is also significantly active with D-galactose as substrate, but not with D-xylose, L-arabinose, D-ribose, D-mannose, D-allose, D-glucosamine, 2-deoxy-D-glucose, or glucose-6-phosphate. Can utilize both NAD+ and NADP+ as electron acceptor, with a marked preference for NADP+ (20-fold higher activity). Physiologically, may be involved in the degradation of both glucose and g

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alactose through a non-phosphorylative variant of the Entner-Doudoroff pathway.