About the Cover

November 2018; Volume 17,Issue 11

Cover image

On the Cover: The geographical range of Zika virus (ZIKV) has expanded dramatically in recent decades, accompanied by a spike in Guillain-Barré syndrome and microcephaly. No antiviral drugs or vaccines are available for the treatment or prevention of ZIKV infection. To learn more about ZIKV biology, we used IP-MS and BioID to map host cell protein interactions for each of the 10 ZIKV polypeptides, generating a protein topology network comprising >3000 interactions among >1200 human polypeptides. Depicted here is the ZIKV life cycle in a human cell (green arrow), along with a number of newly described interactions between ZIKV proteins (blue circles) and host cell organelles. For details, see the article by Coyaud et al., pages 2242–2255.