The larger full-range center like the 160 and 180, even with the cutoff, in my opinion anyway, tends to provide a more "natural" sound to the human voice as opposed to the smaller centers like the 150 that tend to predominate in the 300-500HZ range and what I have always thought to be a more "boxy" somewhat less realistic sound.

Troy, then since you'll be using a good sub and crossing the center over at 80Hz, a good choice is the M2. It has the identical tweeter over mid-range as the VP160 and above about 80Hz is nearly identical to the M22(the dual drivers in the M22 would allow for louder output in the upper bass and mid-range). If the height of the M22 makes it unacceptable for use as a center in your setup, note that the 11 1/2" height of the M2 is identical to the VP160 height and would fit in the same vertical space.

Stilljoe, what is the size of your room? I'm currently deciding on a setup with M22s and either a VP150 or VP160.

My room is just 16 X 11 X 7.5. TV mounted on a short wall with the VP150 below on a cabinet, tilted up (by turning it over and flipping the grille). Fronts are (very) old Boston Acoustics floorstanders until later this year, when I can hopefully pick up M60s. I sit 8-9 feet back from the TV and centre speaker.Majority opinion would say the 160 is more desirable. We found both good but - personal preference - we liked the 150 better.

Troy, then since you'll be using a good sub and crossing the center over at 80Hz, a good choice is the M2. It has the identical tweeter over mid-range as the VP160 and above about 80Hz is nearly identical to the M22(the dual drivers in the M22 would allow for louder output in the upper bass and mid-range). If the height of the M22 makes it unacceptable for use as a center in your setup, note that the 11 1/2" height of the M2 is identical to the VP160 height and would fit in the same vertical space.

I am just concerned a bit about performance levels. My room isa bit over 2100sq ft. I am taking the M22 into work we have a board room pretty well the size of what my movie room is going to be. IBrent emailed my today with my question and it maybe I might have to go with the M60's

There's some disconnect here. The M60s can't play "louder" than the M22s(or for that matter, the M2s)except in the bass. Both the M22 and M60 use the same single tweeter above about 3000Hz. The M22 uses two rather than one 5 1/4" mid-range drivers, so if anything, it would have higher level capability in the mid-range than the M60. The size of the enclosure is significant with regard to bass level and extension, but has nothing to do with mid-range or treble, which is entirely a function of the driver or drivers employed for those frequencies.