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Thrombosis may be regarded as an accident of nature that has not had time to adapt through the lengthy process of evolution to the advances of modern medicine, which allow patients to survive the hemostatic challenge of major surgery and trauma but leave them vulnerable to venous thrombosis. R. W. Colman et al(p3) …each milliliter of blood contains enough clotting material to clot all the fibrinogen in the body in 10 to 15 s. R. I. Handin(p340) Hemostasis consists of platelet plug formation (primary hemostasis) and blood coagulation (secondary hemostasis, coagulation, clotting). Hemostasis and its control involve complex interactions of more than

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