Mouse (Murine) Dynamin 2 (DNM2) interaction partners

Results show that centronuclear myopathy associated Dyn2 mutants are gain-of-function mutations, and their primary effect in muscle is T-tubule disorganization, which explains the susceptibility of muscle to Dyn2 hyperactivity.

Dynamin 2 might participate in the early embryonic development through an actin-based cytokinesis

Dynamin 2 has a role in endocytosis and in sustaining T-cell receptor signaling and driving metabolic reprogramming in T lymphocytes

Thus dynamin (show DNM1 Antibodies) that was recently found to control late stages of myoblast fusion also controls late stages of macrophage fusion, revealing an intriguing conserved mechanistic motif shared by diverse cell-cell fusion processes.

Zebrafish Dynamin 2 (DNM2) interaction partners

DNM2-S619L causes disease, in part, by interfering with membrane tubulation

Our findings suggest that dnm2 and dnm2-like are orthologs to human DNM2, and that they are required for normal zebrafish development.

Pig (Porcine) Dynamin 2 (DNM2) interaction partners

Dynamin 2 possibly regulates porcine oocyte maturation through its effects on actin-mediated spindle positioning and cytokinesis, and that this may depend on regulating ARP2 (show ACTR2 Antibodies) localization.

Dynamin 2 (DNM2) Antigen Profile

Protein Summary

Dynamins represent one of the subfamilies of GTP-binding proteins. These proteins share considerable sequence similarity over the N-terminal portion of the molecule, which contains the GTPase domain. Dynamins are associated with microtubules. They have been implicated in cell processes such as endocytosis and cell motility, and in alterations of the membrane that accompany certain activities such as bone resorption by osteoclasts. Dynamins bind many proteins that bind actin and other cytoskeletal proteins. Dynamins can also self-assemble, a process that stimulates GTPase activity. Five alternatively spliced transcripts encoding different proteins have been described. Additional alternatively spliced transcripts may exist, but their full-length nature has not been determined.