The Epidemiology, Management, and the Associated Burden of Mental Health, Atopic and Autoimmune Conditions in Alopecia Areata

Study Purpose

This study series consists of three related studies and aims to explore and describe many
important elements of Alopecia areata over three key areas: (i) the current epidemiology of
Alopecia areata, (ii) the prevalence and incidence of psychiatric co-morbidities in people
with Alopecia areata and (iii) the prevalence and incidence of autoimmune and atopic
conditions in people with Alopecia areata.

Recruitment Criteria

Accepts Healthy Volunteers

Healthy volunteers are participants who do not have a disease or condition, or related conditions or symptoms

Unknown

Study Type

An interventional clinical study is where participants are assigned to receive one or more interventions (or no intervention) so that researchers can evaluate the effects of the interventions on biomedical or health-related outcomes.

An observational clinical study is where participants identified as belonging to study groups are assessed for biomedical or health outcomes.

Searching Both is inclusive of interventional and observational studies.

Observational

Eligible Ages

N/A and Over

Gender

All

More Inclusion & Exclusion Criteria

Inclusion Criteria:

- Patients contributing to Royal College of General Practitioners Research and
Surveillance Centre(RCGP RCS) primary care database between January 1, 2009 and
December 31, 2018, will be eligible for inclusion.

- Only patients aged ≥18 will be eligible for studies 2 and 3.

- Only patients aged ≥ 18 and ≤ 65 will be included in the unemployment and sick day
analysis (study 2)

Exclusion Criteria:

- People with the alternative non-AA diagnoses.

- People with AA diagnosis within 6 months of registration.

- People with less than 1 year of follow up available

Trial Details

Trial ID:

This trial id was obtained from ClinicalTrials.gov, a service of the U.S. National Institutes of Health, providing information on publicly and privately supported clinical studies of human participants with locations in all 50 States and in 196 countries.

The overall purpose of the first study (Study 1) is to describe the epidemiology of Alopecia
areata (AA) and to assess the current level of primary care service utilisation and
management patterns associated with patients diagnosed with AA.
The overall purpose of the second study (study 2) is to assess the prevalence and incidence
of mental health conditions (depressive episodes, recurrent depressive disorder and anxiety
disorder) in adult patients diagnosed with AA relative to a control population of patients
without a diagnosis of AA. In addition, the study will determine both the treatment, 'sick
day' and unemployment burden. Treatment burden comprises that of medications and
psychological interventions used to treat mental health conditions in adult patients
diagnosed with Alopecia areata.
The overall purpose of the third study (Study 3) is to assess the prevalence and incidence of
atopic and autoimmune conditions in adult patients diagnosed with AA relative to a control
population of patients without AA.

Arms & Interventions

Arms

: Cases

Patients with a confirmed diagnosis of Alopecia areata within the study period will be included as cases for analysis.

: Controls

The control cohorts will be defined by matching cases with patients who have never been diagnosed with Alopecia areata either prior to or during the study period, by age and sex, at General Practice practice level.

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