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URN

etd-0907112-141324

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Author

Kun-Ming Chen

Author's Email Address

No Public.

Department

Chemical Engineering

Year

2011

Semester

2

Degree

Master

Type of Document

Master's Thesis

Language

English

Page Count

121

Title

Studies on Synthesis and Application of Multi-arm Thermosensitive Biodegradable Materials Derived from Polyols

Keyword

sol-gel

PLGA

glycolide

lactide

pentaerythritol

pentaerythritol

lactide

glycolide

PLGA

sol-gel

Abstract

A novel four-arm biodegradable PTOL-(PLGA)4 compound (I) was prepared from pentaerythritol (PTOL) as initiator, stannous octoate Sn(Oct)2 as catalyst, glycolide (GA), and lactide (LA) by ring-opening polymerization. In order to synthesize four-arm [PTOL-(PLGA- mPEG)4], poly(ethylene glycol) monomethyl ether (mPEG) was modified to mPEG carboxylic acid (mPEGacid) at first. Then, the synthesis of [PTOL-(PLGA- mPEG)4] was carried out by esterification reaction with PTOL-(PLGA)4 and mPEGacid. The effect of different hydrophilic and hydrophobic segments of the four-arm [PTOL-(PLGA- mPEG)4] on the phase diagram of gel formation under various polymer concentrations by rheometer and tube turn over methods was investigated.The results showed that with an increase of the concentration of polymers, the temperature transferred from sol to gel decrease, but the temperature transferred from gel to precipitate phase increase. In addition, the temperature transferred from gel to precipitate phase can be increased under 1000ppm BSA solution.