Abstract：Objective To evaluate the association of vitamin D intake in pregnancy with infants asthma. Method VIP,Wanfang,CNKI,PubMed,and OVID databases were searched,in order to collect studies regarding association of vitamin D intake in pregnancy with infants asthma to conduct Meta-analysis. Results Totally 5 prospective cohort studies and 4 RCTs were included in this study.1)All 5 articles had reported that higher maternal intake of vitamin D during pregnancy may significantly decrease the risk of asthma or wheeze in early childhood.2)Two of the fore RCTs were conducted Meta-analysis finally.A total of 1 355 mother-children pairs were enrolled,including 683 pairs in group with vitamin D supplementation and 672 pairs in group with placebo.The Results showed that prenatal vitamin D supplementation was reduced the risk of infants asthma compared to the placebo (OR=0.71;95%CI:0.54～0.92;P=0.01). Conclusion Higher prenatal intake of vitamin D may decrease the risk of infants asthma.