The present study intends to develop a high-performance solar-assisted desalination system (SADS) using multi-effect diffusion type still (MEDS) and the vacuum tube solar collector (VTSC). A MEDS prototype was designed and built. The measured result is very close to the estimation. The 10-effect MEDS will produce pure water at about 13.7 L/day/m2 collector area at a solar irradiation of 600 W/m2 and 19.7 L/day/m2 collector area at solar irradiation 800 W/m2. For 20-effect still, the yield rate increase is 32% compared to 10-effect still.