Thalitero 100mg

Thalitero 100mg is a piperidinyl isoindole basically introduced as a non-barbiturate hypnotic but detached from the market due to teratogenic effects. It has been renewing and indicated for several immunological and inflammatory disorders. Thalitero 100mg displays immunosuppressive and anti-angiogenic activity. It prevents release of tumor necrosis factor-alpha from monocytes and modulates another cytokine action.

Thalidomide

Thalitero

100mg

Hetero

INDICATION

Thalitero 100mg in combination with dexamethasone is indicated for the treatment of patients with newly diagnosed multiple myeloma.
Thalitero 100mg is used for the acute treatment of the cutaneousmanifestations of moderate to severe erythema nodosum leprosum (ENL).
Thalitero 100mg is not used as monotherapy for such ENL treatment in the presence of moderate to severe neuritis.
Thalitero 100mg is also used as maintenance therapy for prohibition and suppression of the cutaneous manifestations of ENL relapsed.

Mechanism of action

The immunologic effects of thalidomide vary considerably under different conditions but may be related to overthrow of exaggerated tumor necrosis factor-alpha (TNF-a) production and down-modulation of selected cell surface adhesion molecules involved in leukocyte migration. For example, patients getting of thalidomide has been resulted to reduce circulating levels of TNF-a in patients with ENL, however, it has also been shown to increase plasma TNF-a levels in HIV-seropositive patients. Since cancer therapy, the drug may work as a VEGF inhibitor.

The dosage recommendation of following condition as follows :Multiple Myeloma :
The recommended dose is 200mg PO qHS in 28-day cycles
Administer 40 mg of dexamethasone on days 1-4,9-12,17-20 of 28 days.
Erythema Nodosum leprosum :
The initial recommended dose is 100-300 mg PO qHS.
In case of more severe reaction then may initiate at 400mg. continue until active symptoms subsided, at least 2 weeks then titrate down by 50 mg increment q 2-4 weeks.

Precautions

Prior initiating Thalitero 100mg treatment, make sure to inform doctor about any other medications you are taking (containing prescription, over-the-counter, vitamins, herbal remedies, etc.). Avoid taking aspirin, or products including aspirin until the doctor especially permits this.
Avoid taking regimens that may cause drowsiness without first consulting your health care provider. Also avoid alcohol.
For both men and women use contraceptives, and do not conceive a child (get pregnant) while taking Thalitero 100mg. serious, life-threatening birth defects may have reported with even one 50 mg dose. Methods of contraception has two types, such as latex condoms and spermicides, are required.
For women of childbearing potential should use contraception 4 weeks before you can start Thalitero 100mg. The manufacturer needed you to take a pregnancy test every month before you initiate a new prescription of thalidomide. This is to confirm that you or your significant other is not pregnant. Consult with your doctor when you may safely become pregnant or conceive a child after treatment.
Do not breast feed while taking this medication.

DRUG – DRUG INTERACTION

Concomitant use of Thalitero 100mg with opioids, antihistamines, antipsychotics, anti-anxiety agents, other CNS depressants may lead to additive sedative effect.

Interaction of Thalitero 100mg with cardiovascular medication will cause an additive bradycardic effect and should be used with caution.

Combination with bortezomib, amiodarone, cisplatin, docetaxel, paclitaxel, vincristine etc will cause peripheral neuropathy and should be used with caution.

Unknown condition when concomitant use of hormonal contraceptives further increases the risk of thromboembolism with Thalitero 100mg

Contraindications

Pregnancy category X: Thalitero 100mg may cause risk to fetal when administer to a pregnant woman. This drug should not administer to a pregnant woman or a woman who aims to become pregnant. If a woman becomes pregnant during Thaliterotherapy, the drug must be discontinued immediately, and the woman given correct counselling.

Take the dose immediately before next dose duration. Next dose time reaches then left off the missed dose and continue regular schedule.
Avoid taking double dose at same time.
Please consult the doctor for further information.

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