Homeobox B5 Proteins (HOXB5)

HOXB5 is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. Additionally we are shipping HOXB5 Antibodies (68) and many more products for this protein.

Human Homeobox B5 (HOXB5) interaction partners

HOXB5 may be an important regulator of the Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signalling pathway, thereby contributing to gastric cancer progression and metastasis.

Roles of Hoxb5 in the development of vagal and trunk neural crest cells.

Overexpression of HoxB5 enhances blood vessel perfusion in vivo by up-regulation of MCP-1 (show CCL2 Proteins) and IL-6 (show IL6 Proteins) as well as in enhanced leucocyte infiltration and blood vessel remodelling.

HOXB5 and HOXB8 (show HOXB8 Proteins) are frequently expressed in ovarian serous carcinoma, with anatomic site-related differences for cytoplasmic staining. HOXB5 may be affected by chemotherapy in effusions.

A miRNA 7-binding single nucleotide polymorphism (1010A/G) located within 3'-UTR of HOXB5 is associated with gene expression and may be a promising prognostic factor for bladder cancer.

HOXB5, HOXB6 (show HOXB6 Proteins), and HOXB7 (show HOXB7 Proteins) are activated in Barrett esophagus, and the midcluster HOXB gene signature in BE most resembled the colon rather than other GI epithelia.

Single nucleotide polymorphism in HOXB5 gene is associated with childhood obesity.

results support that expression of HOX (show MSH2 Proteins) genes is associated with oral squamous cell carcinoma; over 90% of OSCC samples presented HOXB5 expression versus 60% of non-tumor tissues, it can be suggested that HOXB5 may be related to the malignant phenotypes.

The dysregulation of Hoxb5 signaling and early depletion of Neural crest cells contribute to enteric nervous system defect and other neurocristopathies in Hirschsprung disease patients deserves further investigation.

HOXB5 Protein Profile

Protein Summary

This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in lung and gut development. Increased expression of this gene is associated with a distinct biologic subset of acute myeloid leukemia (AML) and the occurrence of bronchopulmonary sequestration (BPS) and congenital cystic adenomatoid malformation (CCAM) tissue.