The purpose of this study is to find the highest dose of an investigational drug called BMS-906024 that can be given safely to adults, adolescents, and children with T-cell acute lymphoblastic leukemia or T-cell lymphoblastic lymphoma that has returned despite or has stopped responding to standard therapy. BMS-906024, which is given intravenously (by vein), inhibits a signaling pathway called Notch that helps cancer cells grow and survive. BMS-906024 also inhibits the development of blood vessels that cancers need to grow and spread.

To be eligible for this study, patients must meet several criteria, including but not limited to the following:

Patients must have T-cell acute lymphoblastic leukemia or T-cell lymphoblastic lymphoma that has returned despite or has stopped responding to standard therapy.

At least 4 weeks must have passed since completion of prior therapy and entry into the study.

Patients must be physically well enough that they are fully ambulatory, capable of all self care, and are capable of all but physically strenuous activities. As an example, patients must be well enough that they would be able to carry out office work or light housework.

Patients must be age 10 or older.

For more information about this study and to inquire about eligibility, please contact Dr. Dan Douer (for patients age 18 and older) at 212-639-2471 or Dr. Neerav Shukla (for patients under age 18) at 212-639-5158.

Clinical Trials

Clinical trials can offer you access to a new, experimental treatment before it is available to most patients. Joining a clinical trial is also a way to make a valuable contribution toward the fight against cancer.