Develop on-site NIH Clinical Center (CC)/NIAID experience in the standard of care of tuberculosis patients with drug sensitive and drug resistant disease, as well as latent tuberculosis.

Characterize in vitro immune responses of patients with tuberculosis to a panel of agonists including but not limited to, strains of Mycobacterium tuberculosis (MTB), MTB antigens, and purified stimuli (e.g. Pam3Cys, LPS, HKLM).

Treatment failure up to Day 28. A subject will be defined as a treatment failure if the subject has developed P. falciparum parasitemia detected by thick blood smear (not by PCR) between the time that parasitemia becomes undetectable and Day 28,...

Alterations in relative abundance and function of peripheral blood cells and specialized subsets as they relate to innate and adaptive immune pathways.

Changes in markers of innate and adaptive immunity as detected in serum, urine, saliva and feces, which may include immunoglobulins, cytokines, chemokines, markers of bacterial translocation and markers of systemic and mucosal inflammation.

Changes in blood, saliva and urine markers of metabolic and hormonal physiology.

100

All

21 Years to 39 Years (Adult)

NCT02707042

16007816-I-0078

March 8, 2016

September 1, 2019

March 1, 2020

March 14, 2016

March 29, 2018

National Institutes of Health Clinical Center, 9000 Rockville PikeBethesda, Maryland, United States

Comparison of efficacy based on symptomatic Urinary Tract Infection (UTI) between short-course and standard-course of antibiotics.

Comparison of number of subjects that have a recurrent infection (includes a relapse UTI or a reinfection) following short-course versus standard-course of antibiotics.

Comparison of the number of subjects that become colonized with antimicrobial resistant Escherichia coli (E. coli) and Klebsiella pneumoniae (K. pneumoniae) in the gastrointestinal tract following short-course versus standard course of antibiotics.

(and 3 more...)

746

All

2 Months to 10 Years (Child)

NCT01595529

09-0103

May 18, 2012

June 30, 2019

December 31, 2019

May 10, 2012

March 23, 2018

Children's Hospital of Pittsburgh of UPMC - General Academic PediatricPittsburgh, Pennsylvania, United States