Feresten was born in Fall River and raised in West Bridgewater, Massachusetts, where he attended public schools. Feresten then attended Berklee College of Music in Boston, where he planned to prepare for a career in music. However, according to Feresten, while there he was kicked out of his dormitory for dropping light bulbs out of his eighth story window, before seeing David Letterman perform the same stunt on his show a few weeks later. "I thought, "God, he is getting paid. This is what network television pays you to do. Maybe I need to think twice about this music career."[1] Feresten dropped out of college in order to attempt a career in television, working first as an intern at NBC in New York, before being promoted to receptionist.[2]

Feresten began his career writing for Saturday Night Live, where he first got the nickname "Spike" while working there as a receptionist. "It came from 'Saturday Night Live'. I was a receptionist, and I had hair licks. And one of the PAs at the time gave me the nickname. And I said, "No problem as long as you don't fire me. Call me whatever you want.".[3] According to Feresten, he started writing for the show when Dennis Miller, who was hosting "Weekend Update", started using jokes that Feresten was passing on to him. "I think my first joke had something to do with Oliver North. I can't remember it. But I remember once it aired, it was like smoking crack."[3]

It's a lot of fun. You come in and read a couple newspapers and start your day with a nice appetizer of opening remarks. And during the day, you get these different writing assignments. We would write four to eight pages of jokes a day -- and at a moment's notice might be flying off to the Daytona 500 with Mujibur and Sirajul.[3]

Two things: First you pitch them an idea that you want to do. Once they say they like the direction you are going, there is a lot of creative freedom, so they let you write it. They send you a list of people they have interviewed as guests. They have already done the interviews. They have the voice of Space Ghost ask a bunch of questions and they have a bunch of responses. You can pick your guest and see if it works within the premise of your show then you get to re-write the questions.[1]

Feresten wrote one episode for The Simpsons during its seventh season, called "Sideshow Bob's Last Gleaming", which aired on November 26, 1995, in which Sideshow Bob escapes once again from prison and takes control of a TV screen at an airshow, demanding all television stations immediately go off the air.
Feresten has said that while he wrote and was credited for the script, it was completely rewritten keeping only the basic ideas intact.[1]

In 1995, Feresten left the late-night realm to join the writing staff of the hugely successful sitcom Seinfeld during the show's seventh season, and stayed there for three seasons until the show's finale, becoming supervising producer in 1998. During his tenure at Seinfeld, Feresten received three Emmy nominations, including one for his famed "Soup Nazi" episode, which remains part of the pop-culture vernacular. The episodes he wrote were:

It ran for three seasons, making it the longest-running late night television show in the history of the Fox network. From January 17, 2009, to February 21, 2009, the show had a six-week test run of hour-long episodes airing an hour earlier than usual; this came in the wake of the cancellation of MADtv. The show was cancelled in May 2009.