Abstract:
The present study intended to evaluate the beneficiary effects of ethanolic extract of Terminalia chebula Retz. fruits (EETC) by using alloxan-monohydrate induced diabetic control by using Wistar Albino rats. The toxicity study was performed on aliquot doses of EETC (100 to 500 mg kg-1 b.wt.) and predetermined the LD50 value on 30 days evaluation; also the behavioral changes, symptoms and mortality have been checked, the EETC showed the nil toxicity up to 500 mg kg-1 b.wt. The effect of EETC (200 mg kg-1 b.wt.) was compared with the glibenclamide (600 mg kg-1 b.wt.) that is often used as a standard drug and the anti-diabetic activity has been conducted for 30 days. After the completion of the study, animals were dissected through cervical dislocation and collected the blood, serum and pancreas. The collected samples were performed under parameters like biochemical and anti-oxidant enzymes related to diabetes such as, weight variation, blood glucose, plasma insulin, serum and liver protein, serum and liver cholesterol, serum and liver triglyceride, serum and liver phospholipids, SGOT (Serum Glutamate Oxaloacetic Transaminase), SGPT (Serum Glutamate Pyruvate Transaminase), ACP (Acid Phosphatase), ALP (Alkaline Phosphatase), GSH (Glutathione reductase), GPT (Glutamate Pyruvate Transaminase), GPX (Glutathione Peroxidase) ,CAT (Catalase) and histopathological sections of the pancreas, the above parameters calculated and showed that the significance at p<0.001 to 0.05. The histopathological changes caused after induction of alloxan showed the granular cytoplasm, dilatation, shrunken nuclei and inflammation, which were reduced after treatment of the EETC (200 mg kg-1 b.wt.). Excess proliferation of epithelium in the pancreas was observed in diabetic rats, which was reduced after administration of the EETC (200 mg kg-1 b.wt.). From the evaluation of the present study on EETC has been confirmed that having the pharmacological action against the diabetic condition, even though the mechanism of the action is unknown, also it can be used further molecular compound analysis and define the chemical to the action.