The exclusion criteria were as follows: (1) Presence of other acute or chronic pulmonary diseases; (2) previous upper respiratory tract infection within 8 weeks of enrollment in the study; (3) current smokers, or abstinence from smoking for <6 months; (4) medication with glucocorticoids and/or LTRA within 4 weeks of enrollment in the study; (5) use of LTRA or glucocorticoid drugs, other than MONT and BUD, during the treatment period; (6) use of antitussive drugs, bronchodilator, anti-histamine drugs or theophylline-based drugs during the treatment period.

The bulbs of various Fritillaria species are traditionally used as an important antitussive, expectorant, and antihypertensive drug in Turkish, Chinese, Japanese, Pakistani and southeastern Asian folk medicines [17].

Upon investigation of the antitussive activity of different polysaccharides on experimentally induced cough in cats, scientists in Slovakia investigated various polysaccharides purified from flowers and plants.

Indication for VITUZ[R] VITUZ[R] Oral Solution is a combination of hydrocodone bitartrate, an antitussive, and chlorpheniramine maleate, a histamine-1 (H1) receptor antagonist, indicated for relief of cough and symptoms associated with upper respiratory allergies or a common cold for adults 18 years of age and older.

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