Lenti-GPC3 CAR (scFv-b2cζ, 9C2)-VP(VP-CAR-LC266)

The ready-to-use lentiviral particles of Lenti-GPC3 CAR (scFv-b2cζ, 9C2)-VP is packaged using 3rd generation of lentiviral packaging system, in which the gene of CAR will be driven by a CMV promotor. The target gene of scFv (9C2)-b2c-CD3ζ packaged in lentiviral particles could be used for high efficency tranduction of T cells and stably integrated expression.

Specifications

Type of Therapeutics

Chimeric Antigen Receptor

Target

Glypican-3 (GPC3)

Expression Cassette

scFv (9C2)-b2c-CD3ζ

Clone

9C2

Promotor

CMV

Packaging System

Lentivirus

Packaging Cell

293T

Targeting Diseases

Hepatocellular Carcinoma (HCC)

Target

Introduction

Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The protein encoded by this gene can bind to and inhibit the dipeptidyl peptidase activity of CD26, and it can induce apoptosis in certain cell types. Deletion mutations in this gene are associated with Simpson-Golabi-Behmel syndrome, also known as Simpson dysmorphia syndrome. Alternative splicing results in multiple transcript variants.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.