Stereotactic body radiation therapy (SBRT) involves giving higher individual doses of radiation over fewer days as compared to standard radiation therapy. It has been very effective in the treatment of small lung lesions and is now the standard of care for inoperable early-stage NSCLC.

Doctors are interested in seeing if SBRT could also be useful to treat patients with larger (locally advanced) NSCLC when given with chemotherapy. In this study, researchers are determining the highest dose of SBRT (doses of at least 40 Gy and up to 60 Gy) that can be given safely to patients with inoperable locally advanced NSCLC.