Historic to Hip: Cincinnati's Over-the-Rhine Neighborhood

Over-the-Rhine (OTR)—known for its Italianate architecture—has gone from historic to hip.

Inventive Japanese gastropub and sushi bar Kaze amps up its ramen with littleneck clams and red miso broth; turkey sliders are piled high with sugar bacon, shiitake mushrooms, and house-made pickles. 1400 Vine St. $$$

The founders of 21c Museum Hotel set their sights on a landmark building for their second art-filled property. Technically just outside of OTR, it displays works in unexpected places; take the lobby floor, where a panel of wormlike neon patterns changes as you walk on it. Make sure to grab a drink on the rooftop terrace. 609 Walnut St.$$

Fresh off a major expansion, Washington Park(picutred)—which abuts the 1870’s-era Music Hall—hosts cultural events year-round. Don’t miss the MidPoint Music Festival (Sept. 26–28), with R&B great Shuggie Otis head-lining. 1230 Elm St.

Family-owned Holtman’s Donuts is a cult favorite for its made-from-scratch treats. The third generation heads up the latest location, serving glazed blueberry, maple bacon, and other flavors. 1332 Vine St.

Restaurant Pricing Key$Less than $25$$$25 to $75$$$$75 to $150$$$$More than $150