Congrats, I have owned 3 22-250's and if I had to pick the best varmint cartridge guess what it would be. My latest is a Win 70 HV stainless with a Leupold 8-25x50mm LR side focus and what a combo! It loves Winchester Supreme amo but I reload a 50 Gr Hornady vmax and 36 gr of IMR 4895 for 3800 fps and it shoots little bug holes in the .2's all day. And I have shot a couple of thousand of rounds thru it.
By buddy says it's Haunted cause everything I point it at dies!
Chuckster

1-14 twist
40 to 55gr bullet weights
When I shot factory I had used Remmy Premier Varmint Ammo. It's loaded with 50gr hornady vmax bullets. Shot pretty well for factory loads.
Now Remington has this to replace it: http://www.remington.com/ammo/center...er_accutip.htm
Haven't tried it.
Are you going to reload?

Once you become addicted to the 22-250 Rem You will have to reload just to afford to shoot. With groundhogs starting to show up you will began missing work and finding yourself to sick to go in on those sunny days. This leads to a reduction of in pay the check.Or worse termination,(hey if I get fired I can hunt every day) Gotta Go take care of something.Just My .02

You have a good choice. I have had very good luck with the 55 gr v-max, 39.4 g., win-760, win l/r primer, win cases. I have about 4,000 rounds down the bore. That load is a little better in my shooter than the H-380. Try both see which your rifle likes the best. Seat the bullet abour .003 off the lands. Let us hear from you after you them! Good luck [img]/ubbthreads/images/graemlins/grin.gif[/img]