This learning program is designed to introduce a type of leukemia known as acute lymphoblastic leukemia or acute lymphocytic leukemia also referred to as ALL. ALL is caused by the rapid overproduction of lymphoblasts which are immature white blood cells from the lymphoid lineage. This learning program first covers the epidemiology of ALL. The pathophysiology diagnosis staging and prognosis of the disease are then reviewed

Upon completion of this learning program you will be able to::

Recall key information about the ALL treatment guidelines.

Recall the specifics of the ALL treatment environment.

Discuss the assessment of response to ALL treatment.

Describe the treatment pathways in pediatric ALL patients.

Describe the treatment pathways in adult ALL patients.

List the complications that can arise during ALL treatment and describe their management.

WELCOME

DISCLAIMER

NAVIGATION INSTRUCTIONS

INTRODUCTION

LEARNING OBJECTIVES

EPIDEMIOLOGY OF ALL

OVERVIEW

INCIDENCE AND PREVALENCE

RISK FACTORS

POP QUIZ

ALL IN CHILDREN

ALL IN CHILDREN (CONTINUED)

PROGRESS CHECK

SECTION SUMMARY

PATHOPHYSIOLOGY OF ALL

NORMAL HEMATOPOIESIS

MALIGNANT TRANSFORMATION OF LYMPHOID STEM CELLS

POP QUIZ

DNA ALTERATIONS

LYMPHOBLASTIC PROLIFERATION IN OTHER ORGANS

LYMPHOBLASTIC PROLIFERATION IN THE CNS

PROGRESS CHECK

SECTION SUMMARY

DIAGNOSIS OF ALL

CLINICAL PRESENTATION

DIFFERENTIAL DIAGNOSIS

DIFFERENTIAL DIAGNOSIS (CONTINUED)

POP QUIZ

DEFINITIVE DIAGNOSTIC TESTS

DEFINITIVE DIAGNOSTIC TESTS (CONTINUED)

IMMUNOPHENOTYPING AND CYTOGENETIC ANALYSES

IMMUNOPHENOTYPING AND CYTOGENETIC ANALYSES (CONTINUED)

POP QUIZ

IMAGING STUDIES IN ALL

PROGRESS CHECK

SECTION SUMMARY

STAGING AND PROGNOSIS OF ALL

STAGING OF ALL

LEUKEMIA OF AMBIGUOUS LINEAGE

POP QUIZ

CLINICAL PROGNOSTIC FACTORS

TREATMENT-RELATED PROGNOSTIC FACTORS

TREATMENT-RELATED PROGNOSTIC FACTORS (CONTINUED)

PROGRESS CHECK

SECTION SUMMARY

TEST YOUR ACQUIRED KNOWLEDGE

SUMMARY

FINAL ASSESSMENT

END OF PROGRAM

GLOSSARY

REFERENCES

This course is accredited for continuing education (CE) by the following organizations:

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