If it's your first time with a new substance, you should check out our Wiki pages on common drugs and the drug knowledgebase (where you can also find links to scales, test kits and various guides) or use the search feature to see if your question has been asked before.

Also take a look at the /r/Drugs FAQs and the psychedelics FAQs below.

I suspect that they just must be much more difficult to produce than, say, 25i-NBOMe, but I still don't see why they wouldn't have significant market potential. It's a whole (largely) unexplored realm of psychedelics.

Also, it makes me question whether ease of manufacture is that much of an issue when stuff like foxy methoxy, AMT, and diisopropylated tryptamines are at least available and legal in many places, even if not particularly commonplace.

Precursors are tightly controlled, even simple syntheses are challenging, profit margins on simpler compounds are huge, ergoloids are illegal in the UK and the US would love to prosecute you for having an LSD analogue... the list goes on.

Were a person with some lab experience to put their mind and a bit of capital towards it, it's not ridiculously difficult. Lysergic acid can be produced from baby woodrose seeds and diethylamine could almost certainly be diverted from a legal operation.

the hard part is tacking on the diethylamide substituent. sure, LSA is easy to get, but getting the sub on without accidentally the whole thing and creating a bunch of garbage is difficult, and it requires a prohibitively long list of reagents to do correctly.

Those are much simpler chemicals to produce and they have much more common precursors. Lysergic acid, however, has very complex chemical bonds, and I believe thus needs to be synthesized out of something containing those bonds. At least in an affordable and realistic scenario.