I run it with SEE2 plugin. And I got internal res at 1024x1024 instead of native mode... Hardware mode seems to work well in this game.

For me framerate drops to around 45 FPS in some heavier scenery (without speedhax).

I run it with only EE cycle x2 enabled. Haven`t had any troubles yet and the game runs smooth.
Best thing is to turn them speedhax on one by one, rather than all at once. (although it does produce some interesting effects )