Abstract

In 1924 Felty1 reported the cases of five adults who had atrophic arthritis associated with splenomegaly and leukopenia. The age of the patients ranged from 45 to 65 years. Their arthritis was generalized, relatively benign, and of at least two years' duration. All patients had suffered recent, marked weight loss. Each had a palpably enlarged spleen that was firm and non-tender. Three of the five had enlarged axillary, inguinal or epitrochlear lymph nodes, and all had some degree of yellow-brown pigmentation of the skin, chiefly on the exposed surfaces. Four of the patients had a slight microcytic anemia, and their