Summaries for TRAJ15 Gene

Entrez Gene Summary for TRAJ15 Gene

T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. If both delta and gamma rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to rearrange the beta and alpha loci. This region represents the germline organization of the T cell receptor alpha and delta loci. Both the alpha and delta loci include V (variable), J (joining), and C (constant) segments and the delta locus also includes diversity (D) segments. The delta locus is situated within the alpha locus, between the alpha V and J segments. During T cell development, the delta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment; a V segment is then joined to the D-J gene. The alpha chain is synthesized by recombination joining a single V segment with a J segment. For both chains, the C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase. Five variable segments can be used in either alpha or delta chains and are described by TRAV/DV symbols. Several V and J segments of the alpha locus are known to be incapable of encoding a protein and are considered pseudogenes. [provided by RefSeq, Aug 2016]

Paralogs for TRAJ15 Gene

No data available for
Paralogs
for TRAJ15 Gene

Variants for TRAJ15 Gene

Relevant External Links for TRAJ15 Gene

No data available for
Polymorphic Variants from UniProtKB/Swiss-Prot ,
Sequence variations from dbSNP and Humsavar ,
Structural Variations from Database of Genomic Variants (DGV) and
Variation tolerance
for TRAJ15 Gene

Disorders for TRAJ15 Gene

No disorders were found for TRAJ15 Gene.

No data available for
MalaCards ,
UniProtKB/Swiss-Prot ,
Genatlas and
External Links
for TRAJ15 Gene