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Background/Purpose: Guillain-Barré Syndrome (GBS) is a neurological disease which generally presents with worsening weakness and altered sensation and, not uncommonly, difficulties with breathing. It can cause long-term disability which is logical for rehabilitative treatment [8]. The purpose of this report is to identify the most effective methods for rehabilitation, specifically related to physical therapy. Case Description: This report is based on Mr. K, the 65 year old male that with complaints of paresthesias and weakness in the upper and lower extremities. MRI of the brain reported negative for stroke, as well as the MRI of the cervical and thoracic spine did not yield evidence of lesion. He underwent extensive diagnostic workup and the final diagnostic impression was that of an acute inflammatory demyelinating polyradiculopathy, Guillain-Barré Syndrome. Outcomes: After a thorough investigation into the available and best' evidence for using rehabilitation interventions in patients with Guillain-Barré Syndrome, it is unfortunate to note that the majority of evidence is of poor design and low quality evidence. Discussion: Given the research found and analyzed here, it can be concluded that physical therapy based interventions are in fact beneficial to increased functional outcomes. While the research is of low levels of evidence with heterogeneity in study design, that does not justify dismissal of the findings, but instead should be considered on an individual basis'