Daniel P. Petrylak, MD, Professor of Medicine (Medical Oncology) and of Urology, Professor and Co-Director, Signal Transduction Research Program, Yale Cancer Center, explains that studies are beginning to look at whether patients will respond to multiple hormonal manipulations or whether they should receive radium-223 before chemotherapy. Petrylak admits that sequencing therapies is starting to get complex; however, he reiterates that the best treatment depends on the site of disease.