RESULTS:

We identified 20 277 HIV-infected and 202 313 HIV-uninfected persons. HIV-infected persons experienced 552 ADC, 221 infection-related NADC, and 388 infection-unrelated NADC. HIV-uninfected persons experienced 179 ADC, 284 infection-related NADC, and 3418 infection-unrelated NADC. The rate ratio comparing HIV-infected and HIV-uninfected persons for ADC was 37.7 [95% confidence interval (CI): 31.7-44.8], with decreases in the rate ratio over time (P < 0.001). The rate ratio for infection-related NADC was 9.2 (95% CI: 7.7-11.1), also with decreases in the rate ratio over time (P < 0.001). These results were largely influenced by anal squamous cell cancer and Hodgkin's lymphoma. The rate ratio for infection-unrelated NADC was 1.3 (95% CI: 1.2-1.4), with no change in the rate ratio over time (P = 0.44). Among infection-unrelated NADCs, other anal, skin, other head and neck, and lung cancer rates were higher and prostate cancer rates lower in HIV-infected persons. Among all infection-unrelated NADCs, the rate ratio decreased over time only for lung cancer (P = 0.007).

CONCLUSION:

In comparison with those without HIV infection, HIV-infected persons are at particular risk for cancers with a known infectious cause, although the higher risk has decreased in the antiretroviral therapy era. Cancers without a known infectious cause are modestly increased in HIV-infected persons compared with HIV-uninfected persons.

Changes in age and CD4+ T-cell counts over time for study participants

Mean age of HIV-infected and HIV-unfected persons for years 1996 to 2007. Mean CD4+ T-cell counts over time also presented for HIV-infected persons. Numbers of HIV-infected and HIV-uninfected persons each year are also presented.

Calendar trends for cancers in HIV-infected and HIV-uninfected persons

Crude incidence rates for any infection-related NADC and any infection-unrelated NADC presented for years 1996–99, 2000–03, and 2004–07. Also presented are individual cancers that either showed statistically significant trends among HIV-infected persons, or differences in trends comparing HIV-infected and HIV-uninfected persons. Annual % change in cancer rates obtained from Poisson regression models adjusting for HIV status, age, sex, calendar period (continuous) and HIV status/calendar period interaction. P-values are presented for annual % change within groups, and for the comparison of HIV+ vs. HIV− annual % change.