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Scientific Interest(s):

Dr. Rajan Singh’s research focuses on understanding the role of nitric oxide synthase (NOS)/arginase axis in breast cancer biology. Utilization of L-arginine through NOS or arginase pathway plays an important role in determining the fate of various cell types, including breast cancer cells. Singh’s research seeks to understand the molecular mechanisms by which NOS/arginase pathway regulate cell proliferation, cytostasis or cell death in human breast cancer cells and identify key molecular targets involved in the process. In addition, Singh is interested in the isolation and characterization of human mammary stem cells to study the mechanisms that govern self-renewal and differentiation.