Bridging fibrosis between portal areas without background cirrhosis, although hepatocyte regeneration (nodular regenerative hyperplasia) may be present, as may parenchymal atrophy secondary to portal malperfusion

Obliteration of portal veins has been specifically linked to didanosine (AIDS 2010;24:1171)

Microscopic (histologic) images

Images hosted on Pathout server:

Images contributed by Raul S. Gonzalez, M.D.

Portal vein radicles

Portal vein herniation

Images hosted on other servers:

Portal tract abnormalities 1

Portal tract abnormalities 2

Board review question #1

A 60 year old man in the United States with no known history of liver disease develops ascites and is discovered to have portal hypertension. He undergoes biopsy, which shows portal tract abnormalities but no cirrhosis. Additional workup determines he has Factor V Leiden. What is the most likely cause of the patient’s portal hypertension?

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