Purpose: :
The influence of a thin central corneal thickness (CCT) on intraocularpressure (IOP) readings has been well documented. It is alsopossible that patients with a thinner cornea respond differentlyto topical medications.

Methods: :
83 patients had been randomized to a prostaglandin antiglaucomamedication and followed for 24 weeks. Pachymetry data were availablefor 75 patients, and were analyzed for a relationship betweenCCT and the magnitude of IOP lowering.

Conclusions: :
Correlation analysis showed that for every 10µ increasein CCT there was 0.30 less IOP decrease between baseline and12 weeks. Since the difference disappeared at week 24, the clinicalsignificance is low. There were no differences between the groupsin the mean difference from baseline IOP at any time point,even at week 12, suggesting that the difference in mean IOPwas a chance finding. If CCT affects IOP readings thin corneaswould be underestimated and thick corneas overestimated. Thiswould tend to increase any differences between the two groups;to minimize this differences from baseline were also analyzed,and no significance was found. Therefore we do not suggest thatCCT will have a significant impact on the results of introducinga topical prostaglandin.