The Giants defense suffers a big setback without Collins, whose 96 total tackles currently leads the team.

The fourth-year pro in in the final year of his contract and is eligible to become a free agent in 2019 unless the Giants designating Collins as a franchise player or sign him to a contract extension ahead of the league's new calendar year.

1. The Cincinnati Bengals shut down wide receiver A.J. Green for the rest of the season, placing him on injured reserve. Green is dealing with a recurring toe injury that could require surgery, NFL Network Insider Ian Rapoport reported Monday. The Bengals activated cornerback Davontae Harris from IR to take Green's spot on the roster.

In other Panthers injury news, quarterback Cam Newton (right shoulder) showed up on the injury report and was a limited participant in practice. Wide receiver Torrey Smith (knee) was also limited.

3. Baltimore Ravens head coach John Harbaugh announced quarterback Joe Flacco (hip) will practice Wednesday, but the head coach doesn't anticipate Flacco to participate fully. Flacco has missed three straight games, a span where backup quarterback Lamar Jackson has led the Ravens on a three-game winning streak.

6. Chicago Bears quarterback Mitchell Trubisky was a full participant in practice. NFL Network's Stacey Dales asked Trubisky on Wednesday if he expects to play this week, and the second-year QB responded, "I do. Just have to show coach ... I feel confident that I'll be ready to go."

7. The Arizona Cardinals announced tackle D.J. Humphries (knee) has been placed on injured reserve. In correlation to the move, the team signed tackle Joe Barksdale, who was waived by the Chargers on Monday, and signed guard Rees Odhiambo from the Indianapolis Colts practice squad.

8. Dolphins head coach Adam Gase says cornerback Xavien Howard is week-to-week with a knee injury, but hasn't exactly ruled him out for Sunday's road game in New England. Gase said Howard injured his knee last Sunday during his second interception of the day against the Bills.

9. The Oakland Raiders had hoped Martavis Bryant would return this season dealing with a knee injury, but the team placed the wideout on injured reserve. The Raiders also placed safety Reggie Nelson (shoulder) and defensive end Shilique Calhoun on IR.

In response to placing three players on IR, the Raiders signed cornerback Bene Benwikiere, running back C.J. Anderson and defensive end Kony Ealy.

10. Denver Broncos wide receiver Emmanuel Sanderstore his Achilles tendon during Wednesday's practice, and has been placed on injured reserve, ending his season. The team proceeded to claim wide receiver Andre Holmes off waivers just hours after the Sanders injury happened. Both defensive end Derek Wolfe and cornerback Tramaine Brock sat out practice dealing with rib injuries.

11. Jets quarterback Sam Darnold (foot) practiced in full, and is expected to start on Sunday in Buffalo. The rookie hasn't played since Week 9.

12. Titans linebacker Derrick Morgan (knee) returned to practice Wednesday but was limited, and is officially questionable for Tennessee's AFC South home stand against the Jaguars on Thursday Night Football.

17. New Orleans Saints tackle Terron Armstead (pectoral) returned to practice for the first time since getting injured in the team's Nov. win over the Bengals. Armstead missed three games total because of the injury, and although he was limited, it was a good sign for his return this Sunday. Meanwhile, wide receiver Michael Thomasmissed practice with an ankle injury.

18. The Green Bay Packers have placed cornerback Kevin King (hamstring) on injured reserve, and in a corresponding move, claimed CB Natrell Jamerson off waivers.

19. San Francisco 49ers running back Matt Brieda (ankle) and Jaquiski Tartt (shoulder) did not practice.

20. Los Angeles Chargers defensive tackle Brandon Mebane returned to practice. The 12-year veteran has been away from the team dealing with family matters, forcing him to miss the last two games.