Actor Meg Ryan has coughed up $US8 million for the New York loft apartment of Hank Azaria, the man behind the voice acting of much of The Simpsons.

Ryan's three-bedroom purchase coincides with a report by CNN that she has broken up with singer-songwriter John Mellencamp after three years. The rom-com star - When Harry Met Sally, Sleepless in Seattle and You've Got Mail - sold her LA home in Bel Air in 2012 for $US11,125,000, but reportedly still owns her Martha's Vineyard getaway.

Azaria and his therapist wife, Katie Wright, had owned the converted warehouse spread in the Soho district since 2005 when they paid $US4,625,000 for it from artist Cindy Sherman, according to Variety.

But the sale by the Azaria-Wrights marks a step up in their real estate fortunes. They bought a double apartment spread on Central Park West earlier this year, for which they paid $US9,225,000.