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Table

Systemic symptoms like fever or subfebrile status, weight loss, or stunted growth, and ≥2 areas of involvement beyond the site of BCG vaccination†

Identification of Mycobacterium bovis BCG substrain from the patient’s organs by culture and/or standard PCR, as well as typical histopathologic changes with granulomatous inflammation

Probable

Systemic symptoms like fever or subfebrile status, weight loss or stunted growth, and ≥2 areas of involvement beyond the site of BCG vaccination†

Identification of M. tuberculosis complex from the organs by PCR, without differentiation of M. bovis BCG substrain or other members of the M. tuberculosis complex and negative mycobacterial cultures, with the presence of typical histopathologic changes with granulomatous inflammation

Possible

Systemic symptoms like fever or subfebrile condition, weight loss or stunted growth, and ≥2 areas of involvement beyond the site of BCG vaccination†

No identification of mycobacteria by PCR and culture, with presence of typical histopathologic changes with granulomatous inflammation

Exclusion criteria

Any inflammation without typical histopathologic changes, with no isolation of M. tuberculosis complex by PCR analysis in patient with primary immunodeficiency

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