The difference of the regular, high-molecular hyaluronic acid (HA) and
low-molecular-weight HA is that the low-molecular weight HA has been split into smaller fragments. Thereby, these smaller fragments can no
longer form a gel with water like the large molecules, but they can penetrate
the skin much easier and have actually a better anti-irritant and regenerating
effect once absorbed by skin. The high molecular form of HA has a better
hydrating effect than the low-molecular form of HA.