ISO LOADING PROBLEM?

For some reason when I load the new iso game the simpson up it checks memory then 1 sec after that black screen and nothing else shows up. Anyone know whats up? I am running a 3.52 m33-4. I tried it on 2 psp's so it is not the memory stick problem. It does not freeze or nothing I am able to go home. THIS only happens on this 1 game, the other iso games all work for me.