Safyral

"Oct. 18, 2012 -- While the use of long-acting intrauterine devices (IUDs) is increasing, 1 in 9 women at risk for unintended pregnancies is not using any birth control, according to a new government report.

Cigarette smoking increases the risk of serious
cardiovascular events from combination oral contraceptives (COC) use. This risk
increases with age, particularly in women over 35 years of age, and with the
number of cigarettes smoked. For this reason, COCs should not be used by women
who are over 35 years of age and smoke [see CONTRAINDICATIONS].

Drospirenone
(6R,7R,8R,9S,10R,13S,14S,15S,16S,17S)-1,3',4',6,6a,7,8,9,10,11,12,13,
14,15,15a,16-hexadecahydro10,13-dimethylspiro-[17H-dicyclopropa-[6,7:15,16]
cyclopenta[a]phenanthrene-17,2'(5H)-furan]-3,5'(2H)-dione) is a synthetic
progestational compound and has a molecular weight of 366.5 and a molecular
formula of C24H30O3.

Ethinyl estradiol (19-nor-17α-pregna
1,3,5(10)-triene-20-yne-3,17-diol) is a synthetic estrogenic compound and has a
molecular weight of 296.4 and a molecular formula of C20H24O2.

Levomefolate calcium
(N-[4-[[(2-amino-1,4,5,6,7,8-hexahydro-5-methyl-4-oxo-(6S)-pteridinyl)methyl]amino]benzoyl]L-glutamic
acid, calcium salt) is a synthetic calcium salt of L-5-methyltetrahydrofolate
(L-5-methyl-THF), which is a metabolite of vitamin B9 and has a molecular
weight of 497.5 and a molecular formula of C20H23CaN7O6.

The structural formulas are as follows:

Drospirenone

Ethinyl estradiol

Levomefolate Calcium

What are the possible side effects of this medication (Beyaz, Safyral)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using birth control pills and call your doctor at once if you have a serious side effect such as:

What are the precautions when taking drospirenone/ethinyl estradiol/levomefolate calcium tablets and levomefolate (Safyral)?

See also Warning section.

Before taking this medication, tell your doctor or pharmacist if you are allergic to drospirenone, ethinyl estradiol, or folate supplements; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.