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UPDATE: Research into Blood Flow in the Brain and Venous Insufficiency, or CCSVI, in Multiple Sclerosis

Summary: Recent reports are calling attention to the idea that a phenomenon called CCSVI, a dysfunction of brain blood flow and/or blood drainage may contribute to nervous system damage in MS. This hypothesis has been put forth by Dr. Paulo Zamboni from the University of Ferrara in Italy. Based on the results of his initial findings, Dr. Zamboni reports that this pilot study warrants a subsequent randomized control study and he hopes to encourage this additional research to evaluate the possible impact of CCSVI on disease process in MS.

It has been proposed by Dr. Zamboni, but not yet proven, that CCSVI may be corrected through an endovascular surgical procedure that has been called “liberation therapy.” The National MS Society is undertaking the funding of follow-up research in CCSVI in MS and has invited investigators to apply for grant funding that would explore this lead. These applications will undergo an accelerated review process. If this hypothesis is confirmed, it may open up new research avenues into the underlying pathology of MS and new treatment approaches to therapy.

Background: In a recent study by Dr. Zamboni and colleagues, the team screened for abnormalities of blood outflow in major veins draining from the brain to the heart in 65 people with different types of MS, compared with 235 people who were either healthy or who had other neurological disorders. They used sophisticated sonography techniques to detect abnormalities of venous drainage. The investigators reported significant evidence of slowed and obstructed drainage in the veins draining the brain in many of those with MS. They also found evidence of the opening of “substitute circles” – where the flow is deviated to smaller vessels to bypass obstructions, and these were often found to have reverse flow (reflux) of blood back into the brain.

The investigators call this venous obstruction “chronic cerebrospinal venous insufficiency,” or CCSVI. The treatment status of the people with MS (whether or not they were on an MS disease modifying drug) did not appear to influence whether they showed signs of CCSVI. The authors speculated that the reverse flow of blood back into the brain might set off the inflammation and immune-mediated damage that has been well described in MS. This study was published in June 2009 (J Neurol Neurosurg Psychiatry 2009; 80:392-399).

Next Steps: Dr. Zamboni’s hypothesis, if confirmed, may open up new research avenues into the underlying pathology of MS and new approaches to therapy. Dr. Zamboni himself has stated that additional research is essential to evaluate his hypothesis and how it might impact the disease process in MS, and further research is now in progress.

The National MS Society is pursuing follow-up research in CCSVI in MS and we have invited investigators whose research is relevant to MS to submit proposals to apply for grants that would explore this lead. These applications will undergo an accelerated review process. We are also working with our sister MS Societies around the world to assure that our research strategies are coordinated.

It has been proposed, but not yet proven, that CCSVI may be corrected through endovascular surgery which involves inserting a tiny balloon or stent into blocked veins in order to permit the flow of blood out of the brain. This surgery is being called “liberation therapy” in some reports. One study getting underway was described at the 2009 ECTRIMS meeting in September. It involves a collaboration between researchers in Italy, Buffalo (NY) and Birmingham (AL) who are attempting to treat venous obstruction in 16 individuals using balloon dilation such as has been used for many years to treat blocked arteries.

According to the Buffalo Neruoimaging Analysis Center, although 500 subjects have already been selected for their initial combined transcranial and extracranial venous doppler evaluation study, they are still seeking participants for a larger-scale clinical study with the aim of evaluating the prevalence of venous obstruction in people with MS. This study does not involve treatment of obstructions.

To get the quickest answers and most reliable results about benefits and risks of any surgical procedure that might attempt to address blood flow in or out of the brain, it is crucial that such surgery be performed only as part of controlled trials, especially since there have been anecdotal reports of surgical attempts to treat CCSVI in people with MS resulting in adverse events, including one reported death.

Many questions remain about how and when this phenomenon might play a role in nervous system damage seen in MS, and at the present time there is insufficient evidence to prove that this phenomenon is the cause of MS.

Frequently Asked Questions About CCSVI and MS

Q: What is the National MS Society’s view of CCSVI?
A: In trying to find the cause and more effective treatments for a disease as complex and unpredictable as multiple sclerosis, it is important for researchers to think outside the box and we believe Dr. Zamboni has done this. His hypothesis is an intriguing one, and Dr. Zamboni himself has stated that additional research is essential to evaluate it.

Q: Will the National MS Society fund research into CCSVI in MS?
A: The National MS Society is pursuing follow-up research in how CCSVI might be involved in the MS process and we have invited investigators whose research is relevant to MS to submit proposals to apply for grants that would explore this lead. These applications will undergo an accelerated review process.

Q: Do the reports of a possible association between insufficient vein drainage and MS mean that MS is caused by venous insufficiency?
A: No. Based on results published about these findings to date, there is not enough evidence to say that obstruction of veins causes MS, or to determine when this obstruction may occur in the course of disease.

Q: If CCSVI turns out to be important in MS, can it be treated?
A: No one knows yet. Surgical procedures for CCSVI in MS are still experimental and should be undertaken only as part of formal clinical trials that include all of the standard safeguards that are followed in such trials.

Q: How can I get involved in research on CCSVI in MS?
A: A larger-scale clinical study is getting underway in Buffalo, New York and is now recruiting participants nationwide with the aim of evaluating the prevalence of venous obstruction in people with MS. This study does not involve treatment of venous obstructions.

Q: I have MS. Should I be tested for signs of CCSVI?
A: We do not recommend testing for signs of CCSVI unless you are involved in a research study exploring this phenomenon, since at this time there is no proven therapy to resolve any abnormalities that might be observed, and it is still not clear whether relieving venous obstructions would be beneficial.

Q: Does CCSVI make the standard treatments of MS meaningless?
A: No. There is ample evidence proving that the FDA-approved therapies for MS provide benefit for people with most forms of MS.

Q. How can I continue to be informed of CCSVI developments as they occur?
A: As new information becomes available about CCSVI, it will be posted on the National MS Society’s Web site, www.nationalMSsociety.org

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Thanks for posting this. It is much more positive than their last update and goes to show how quickly the ms landscape is changing. They must see people's posts saying they will not donate money to organizations with high administrative overhead and where their dollars aren't going for CCSVI research. The NMSS can't afford to lose income.

This is interesting -- did the NMSS feel a little competition from the excellent article written by Dr. Jack Burks for the MSAA (Multiple Sclerosis Assoc. of America)? All I can say is "Woo, hoo" - a little competition never hurt anybody - right?

I am sure the NMSS saw comments from people all over the country saying they were going to be donating to the MSAA this year -- money talks again!

Anyway, I am glad to see the NMSS taking a more positive attitude. We need anybody and everybody. They still did not delete the anecdotal report about one death -- how many of us emailed the NMSS about this falsehood? So, if the NMSS is lurking -- please read the TIMS posts about this death -- it was unrelated to the CCSVI procedure.
http://www.thisisms.com/ftopict-8028-holly.htmlhttp://www.thisisms.com/ftopic-7886-day ... sc-30.html Go to page #3.
Please, NMSS out of respect for the family, edit your story.

They still did not delete the anecdotal report about one death -- how many of us emailed the NMSS about this falsehood?

I did, four times to three different people -- on the National website, our local chapter, and twice in the dialoge I've had with a very nice lady at the NMSS in Colorado. Looks like that part hasn't gotten through yet.

I did, four times to three different people -- on the National website, our local chapter, and twice in the dialoge I've had with a very nice lady at the NMSS in Colorado. Looks like that part hasn't gotten through yet.

Thank you for taking the time to contact the NMSS. Maybe I am making a bigger deal of this than it should be, but I just feel that I owe it to Holly and her dear family to set the story straight especially since the NMSS is announcing this over a worldwide Internet.

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