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5-HTP is contra-indicated for anyone on SSRIs or a number of other anti-depressant medication, as you are putting yourself at risk of inducing seratonin syndrome, a potentially fatal condition caused bt flooding your central nervous system with seratonin. The symptoms described by Jenn above look like a mild onset of SS. Anyone on anti-depressant or opioid medication should seek medical advice before considering taking 5-HTP, as the outcome may of such a combination may not be a happy one.

Tony |
February 14, 2015

Try gaba

October 26, 2014

5-htp should not be taken with ssri... I take 300 mg per day, since 2008, no such effects. (while having lot of anxiety, i am not scared of 5-htp...)

Bernhard |
October 8, 2014

I am taking Celexa an SSRI and wanted to taper off so I went from 20mg to now 10mg which sucks for my mood and headaches. I took one pill of the 5HTP to offset my deminished Celexa and waited 15 minutes and ate some ice cream ~ I immediately felt numb, cold sweats, clammy and vomited all of my ice cream, bummer, I'm scared to try another 5HTP pill :(

Serotonin syndrome is not caused by an impurity in a supplement. Serotonin syndrome describes a rare state wherein the body makes too much serotonin or doesn't clear it properly, usually because two or more medications affecting serotonin levels have been mixed. This usually involves large doses of something like a cold medicine being taken on top of an antidepressant or recreational abuse of a substance that affects serotonin levels. (Robitussin, f

August 26, 2014

what brand were you using? did you ever look up literature to see if they conducted an assay on your particular brand? 5HTP is a naturally occuring chemical in your body and generally those who are depressed have a deficency. I think you are correct about it being synthetic but it sounds like they were selling something other than advertised. Lastly, eosinophils are a natural type of white blood cell in every human. they can be involved in serious blood disorders but those with eosinophils so

So sorry you experienced that, I was warned that taking 100mg is the max daily and only if you really are not getting it anywhere else. (turkey, walnuts, other foods that produce it) I only take 50mgs and 100 on occasion.

I've been taking 5-HTP for chronic anxiety disorder (CAD) and depression for about 3 years nowand have never experienced what all the above have. You start out slowing taking 5-HTP, asindicated on the bottle, and I never exceeded 3 per day. I'm now down to only one per day, stated on the bottle, and I never took it before bedtime. I don't have anxiety or depression while I'm sleeping, so why would I need to. My doctor paired it with Gaba Calm, so ask your healthcare professional if he/

Kay |
June 21, 2014

I heard that it could cause aggression and road rage type symptoms. I have not experienced this though, and I've been taking it for about 4 weeks. I've actually had more restful sleep since starting it and seem a little more relaxed.