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Shamban graduated from Harvard University before receiving her medical degree from Case Western Reserve Medical School.[citation needed] She completed an internal medicine internship at the Mount Sinai Medical Center and went into practice as a general practitioner in California for two years. She then received a Dermatology Foundation Fellowship for the study of extracellular matrix proteins, with Dr Jouni Uitto. Shamban continued on to complete her dermatology residency at Harbor-UCLA Medical Center in 1989 and is currently a member of the American Society for Dermatologic Surgery as well as the American Academy of Dermatology, and also serves on the editorial board of The Journal of Clinical and Aesthetic Dermatology.[2]

Shamban was a recurring cast member of the ABC TV show "Extreme Makeover," from 2003-2007,[3] where she provided skincare consultations for participants. She also appeared on multiple episodes of the TV show "The Doctors," where she discussed skin care issues.[4][5]

Shamban is the owner and director of two dermatology practices in Los Angeles.[6] The Santa Monica practice has been open for 20 years, while the Beverly Hills location opened 9 years ago. Shamban also serves as Assistant Clinical Professor of Dermatology at the UCLA Geffen School of Medicine.[7]

Shamban has authored one book,[8] and is involved in research and clinical trials for dermatologic products and devices.[9] She has also recently become the host of the new Condé Nast Entertainment digital series, “Dr. Ava Says” as an Allure Insider.[10]