Lucero (2010) writes of therapeutic hypothermia "resumption of spontaneous circulation after prolonged ischemia due to cardiac arrest carries significant morbidity and mortality and much effort has been directed toward reducing the debilitating consequences." Lucero reviews the studies that demonstrate an association between therapeutic hypothermia in post-cardiac arrest patients and improved neurological outcomes.

Lutes and Larsen (2007) reviews recent studies that examine the use of therapeutic hypothermia, its purpose and goals as well as the methods of initiating and maintaining hypothermia and the future possible uses of therapeutic hypothermia.

Oddo, et al. (2008) examines the early predictors of outcome in patients who are comatose survivors of ventricular fibrillation and non-ventricular fibrillation cardiac arrest who were treated with hypothermia.

Rittenberger (2010) reviews the use of therapeutic hypothermia for patients with cardiac arrest and holds that therapeutic hypothermia is a potent therapy for use in these patients.

7. Koran, Zeb E. (nd) Therapeutic Hypothermia in Postresucitation Patient: The Development and Implementation of an Evidence-Based Protocol in the Emergency Department. Retrieved from: http://www.acestar.uthscsa.edu/institute/su09/documents/Koran.pdf

Koran (nd) conducts a systemic literature review on postresucitation hypothermia and a subsequent development of a protocol that provides evidence-based criteria for patient inclusion and exclusion in the use of hypothermia initiation.

Eisenberger, et al. (2001) report that hypothermia has been used for cerebral protection "since the 1950s" and that the "simple principle of chemistry that a reduction of 10 degrees C. slows a chemical process by approximately 50%." In addition, it is reported that one hour or hypothermia, followed immediately by 3 hours rewarming had no significant affect on patterns of cerebral blood flow and oxygen uptake.

Walsh and Edelson (2009) review the history of the use of therapeutic hypothermia in patients with cardiac arrest as well as the pathophysiology of therapeutic hypothermia in patients with cardiac arrest.

Therapeutic Hypothermia Review

Part Two

The work of Sayre (2010) entitled "Effect of Pre-Hospital Therapeutic Hypothermia on Neurologic Outcome Following Sudden Cardiac Arrest" reports an EMS Trauma Research study of the Ohio Department of Public Safety. The study reports that sudden cardiac arrest is the "leading cause of death in the United States and Canada." The report additionally states that 450 cardiac arrest resuscitations are "attempted by EMS…in Columbus, Ohio each year" however it is additionally stated that only approximately 30% of those patients "survive to be admitted to the hospital." (Sayre, 2010, p. 3)

Sayre (2010) reviews the future trends both regionally and nationally and states that future trends include the "continued provision of the therapy…" (Sayre, 2010, p.3) Sayre et al. (2010) report a study that was conducted through comparison of SCA statistics for the years 2008 and 2009. No increase in the survival rates…[continue]

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