1Advanced MRI, LFMI, NINDS, NIH, Bethesda, MD, United States, 2Georgetown Center for Functional and Molecular Imaging, Washington, DC, United States, 3Program for Translational Research on Adversity and Neurodevelopment, The Pennsylvania State University, University Park, MD, United States

The spatiotemporal growth trajectories of white
matter, and in particular myelin, are an important part of cognitive
development during adolescence. Quantitative magnetization transfer (qMT)
imaging can be used to measure the fraction of non-water protons (fMT) as an estimate of myelin
in vivo. Here we used a recently
developed, time-efficient pulsed MT approach to extract fMT from white matter regions at different stages of
development in a community-based cohort of adolescents. We tested the sensitivity of this
approach for detecting region-specific change in fMT in repeated scans that covered a period of 18
months.

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