India's DNA fingerprinting pioneer Lalji Singh passes away

Lalji Singh, widely regarded as the father of DNA fingerprinting in India, and a former director of Hyderabad-based Centre for Cellular and Molecular Biology (CCMB), passed away
late last night (10 December, 2017) at the age of 70.

His death plunged CCMB into grief as it comes close on heels of the passing away of the centre's founder director Pushpa Mittra Bhargava in August this year.

Singh was about to catch
a flight from Varanasi to Delhi when he complained of chest pain and died before he could be reached to the Banaras Hindu University (BHU) Trauma Centre.

He had retired from
active professional life in 2014 after serving a successful stint as the
Vice-Chancellor of the BHU. Singh was a recipient of
India's civilian honour Padma Shri.

A pioneer of DNA
fingerprinting in India, Singh was highly regarded for his significant
contributions in the areas of molecular basis of sex determination, wildlife
conservation, silkworm genome analysis, population genetics and ancient DNA
studies. In a glorious 45-year-long scientific career, Singh published around
219 research papers, including a 2009 work reconstructing Indian population
history that made it to the cover of Nature1.

The 24 September 2009 cover of Nature featuring Lalji Singh's work. Singh created the cover image for the issue with colleagues K. Thangaraj and F. Amirtharaj.

Singh was the driving
force behind the establishment of avant-garde facilities in India such as the
Laboratory for the Conservation of Endangered Species (LaCONES) for
conservation of endangered wildlife in India and the Centre for DNA
Fingerprinting and Diagnostics (CDFD). Known for his affable nature, ever-smiling disposition and public spirited endeavours, he also floated the not-profit Genome Foundation for
diagnosis and treatment of genetic disorders especially those affecting underprivileged, rural people.

His leading-edge work in
devising a probe from a highly conserved DNA sequence in a species of Indian snake — the Banded Krait Minor (Bkm) — opened up a world of possibilities in
forensic investigations, paternity determination and seed stock verification.
It was called the Bkm-derived probe for DNA fingerprinting.

Singh appeared in Indian courts several times to establish the veracity of this scientific
technique in many high profile forensic cases. The technique has been used in
more than 300 forensic investigations including that of the assassination of India's former
Prime Minister Rajiv Gandhi, the 1995 Naina Sahni tandoor murder case and the 1996 Priyadarshini Mattoo murder case.

Singh's population
genetics studies also led him to look at primitive tribes of the far flung
Andaman and Nicobar Islands in the Indian Ocean, thereby unraveling the
evolution and migration of humans from these tiny landmasses about 60,000 years
ago.