IL-17E is a disulfide-linked homodimer of two 145 amino acid polypeptide chains.It belongs to the IL-17 family of structurally-related cytokines that share a highly conserved C-terminal region, but differ from one another in their N-terminal regions and in their distinct biological roles.The six known members of this family, IL-17A through IL-17F, are secreted as homodimers.IL-17E stimulated secretion of IL-8, and induces activation of the transcription factor NF-kappaB in cells that express the IL-17BR receptor.Recombinant human IL-17E is a 33.8kD disulfide-linked homodimer of two 145 amino acid polypeptide chains.

Catalog #

143390

Biological Activity

Determined by its ability to induce IL-8 in human PBMCs using a concentration range of 10-100ng.

Store lyophilized products at -20°C. For reconstituted solutions of most products, we recommend short-term storage at 4°C. For longer term storage the protein solution should be stored with a carrier protein (eg. 0.1% BSA) in working aliquots and stored frozen at -20°C. Additional freeze/thaw cycles may cause some denaturation of the protein.

Source

E. coli

Purity

98% by SDS-PAGE gel and HPLC analyses.

Form

Supplied as a lyophilized powder.

Important Note

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.