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[RB4E08] Resident Evil 4 Crashing PLEASE HELP [HELP!]

Okay, so.... I've been playing Resident Evil 4 for a while and at first when I got it I used Neogamma to run it since it's in a disc. I used verbatim w/ 4dx writing speed on IMGburn. Neogamma was on iOS 249 and the game loaded and stuff so i put new game and the cutscene started then when it was time for me to play it said it could not read the disc so then I changed it to iOS 250 and it worked, but every once in a while when I open doors or when some cutscenes load (THERES A LOT OF DOORS BTW SO LOTS OF CRASHING WHICH GETS ANNOYING) the game crashes and says:

The Game Disc could not be read. Please read the Wii operations manual for more information.

So then I realized that when I load the game in Neogamma it says:

The requested iOS is iOS = 21

So then I downloaded iOS 249 rev21 and the game didn't even load the title screen or anything.

I went back to 250, but it crashes when I open doors and what not...
Is there a different iOS 21 or what? What iOS should I use? What settings?

HELP PLEASE!
It gets really annoying when it crashes and it repeats until magically it just stops and lets me continue...and if I don't save I get reset way back !
My Wii is 4.3U if that matters.