Abstract

To the Editor: Human immunodeficiency virus (HIV)-associated nephropathy usually manifests as the nephrotic syndrome with glomerular lesions of focal and segmental glomerulosclerosis. The disease rapidly progresses to end-stage renal failure in months or even weeks. Such unusually rapid progression of HIV-related focal and segmental glomerulosclerosis has mainly been observed in drug addicts and in blacks (1, 2). No reports are available concerning the influence of zidovudine (AZT) treatment on the course of HIV-associated nephropathy. We present a case of focal and segmental glomerulosclerosis in which zidovudine appeared to induce an 11-month remission of the nephrotic syndrome.