The authors report the development of small interfering RNA-releasing poly(amine-co-ester) nanoparticles, distinguished by their high content of a hydrophobic lactone. They showed that a single transfection of small interfering RNA targeting class II transactivator attenuates major histocompatibility complex class II expression on endothelial cells for at least four to six weeks after transplantation into immunodeficient mouse hosts. [Nat Commun]
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Scientists found that chemical inhibitors, RNAi silencing, and genetic knockout of TRPM2 channels abolished the ability of high glucose to cause mitochondrial fission in endothelial cells, a cell type that is particularly vulnerable to diabetic stress. [Sci Signal]
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Investigators examined the role of combinatorial extracellular matrix (ECM) proteins on endothelial differentiation systematically using an arrayed microscale platform. Human pluripotent stem cells were differentiated on the arrayed ECM microenvironments for five days. [Sci Rep]
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Researchers investigated the effect of alginate-gelatin encapsulation on angiogenic behavior of human endothelial cells over a period of five days. They demonstrated that encapsulation promoted HUVEC survival and proliferation. [Biotechnol Bioeng]
Abstract

Distinct organotypic functional attributes as well as the molecular mechanisms controlling endothelial cell differentiation and vascular bed-specific functions have only emerged in recent years. The authors summarize recent progress in the understanding of organotypic vascular differentiation and function. [Science]
Abstract

Pathologies that damage endothelial function result in corneal decompensation and, if untreated, blindness. The authors summarize the case reports describing complications post-operatively in the form of (sub)total graft detachment and those resulting in post-operative bare stroma. [Surv Ophthalmol]
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A new partnership between Stanford and one of the world’s oldest and largest drug makers, Takeda Pharmaceutical Company Ltd., could help speed up the process of bringing drugs from discovery to market. [Stanford University]
Press Release

Ophthotech Corporation announced that the pre-specified primary endpoint of mean change in visual acuity at 12 months was not achieved in its Phase III clinical trial investigating the superiority of Fovista® anti-PDGF therapy in combination with Eylea® or Avastin® anti-VEGF therapy compared to Eylea® or Avastin® monotherapy for the treatment of wet age-related macular degeneration. [Ophthotech Corporation]
Press Release

Scientists, engineers, and others are hoping an Egyptian court will reconsider a prison sentence given to one of the nation’s most prominent science advocates. In a surprising outcome, an Egyptian judge sentenced Ismail Serageldin, founding director of Egypt’s Library of Alexandria, to three and a half years in prison for financial misdemeanors. [Science Insider]
Editorial

Earlier surveys of Americans found a reluctance to support human genome editing, with many respondents expressing ethical and other concerns about such intentional tinkering. A new survey found that two-thirds of the 1600 respondents thought genome editing was generally “acceptable.” But that acceptance was qualified, and colored by religious beliefs and scientific knowledge. [ScienceInsider]
Editorial

Thousands of scientists, university students and science enthusiasts gathered in dozens of Indian cities to march in support of science — lamenting their country’s low levels of funding for research, and complaining about government promotion of ‘unscientific ideas’. [Nature News]
Editorial