Biomedical Research

Characteristics of bacterial infection in patients with diabetic foot and its relationship with degree of vascular lesions in lower extremities

Objective: To analyse the infection characteristics of pathogenic bacteria in diabetic foot infection and its relationship with the degree of vascular lesions in lower extremities.

Methods: 103 cases of patients with diabetic foot complicated with infection admitted to our department from 2009 to 2014 were collected. During hospitalization, all patients underwent double lower limbs CTA or lower extremity angiography examination, and were divided into 4 groups according to the classification (A~D) of Trans-Atlantic Inter-Society Consensus (TASC). χ2 test was adopted to analyse whether there was a difference in pathogenic characteristics and drug resistance between different TASC groups. Single factor variance analysis was used to clear and definite whether there were differences between different TASC groups.

Results: There were differences in the comparison of age, duration of diabetes, ABI, TBI, percentage of neutrophils between groups, which were statistical significance (t=14.36, P=0.000; Z=30.88, P=0.001; χ2=6.76, P=0.000; χ2=11.56, P=0.006; t=56.16, P=0.039). Among the comparisons of TASC groups, with increased degree of lower extremity vascular lesions, proportion of mixed infection was gradually increased, and there were significant differences in the incidence of mixed infection (P=0.004), besides, among patients with grade D, mixed infection cases accounted for 66.7%.