Basis for original (SCP) IDLH: The chosen IDLH is conservative, but the only data available on which to base the IDLH is the statement by Patty [1963] that Smyth [1956] found rats survived when exposed for 4 hours to 8,000 ppm. The IDLH for isobutyl alcohol is also 8,000 ppm.

Short-term exposure guidelines: None developed

ACUTE TOXICITY DATA

Lethal concentration data:

Species

Reference

LC5o

(ppm)

LCLo

(ppm)

Time

Adjusted 0.5-hr

LC (CF)

Derived

Value

Mammal

Rat

Esin and Vigdergauz 1986

NPIRI 1974

9,221

8,000

-----

-----

?

4 hr

?

16,000 ppm (2.0)

?

1,600 ppm

Lethal dose data:

Species

Reference

Route

LD50

(mg/kg)

LDLo

(mg/kg)

Adjusted LD

Derived value

Rabbit

Rat

Dog

Munch 1972

Purchase 1969

Wurtz 1975

oral

oral

oral

-----

-----

-----

3,484

790

1,700

7,918 ppm

1,795 ppm

4,000 ppm

792 ppm

180 ppm

400 ppm

Other animal data: RD50 (mouse), 4,784 ppm [Alarie 1981].

Human data: It has been reported that corneal irritation was occasionally observed in workers exposed to 200 ppm [Sterner et al. 1949].

Revised IDLH: 1,400 ppm [LEL]

Basis for revised IDLH: Based on health considerations and acute inhalation toxicity data in animals [NPIRI 1974], a value of about 1,600 ppm would have been appropriate for n-butyl alcohol. However, the revised IDLH for n-butyl alcohol is 1,400 ppm based strictly on safety considerations (i.e., being 10% if the lower explosive limit of 1.4%).