James Bishop (Matt Stasi) is the newest doctor on the floor at the St. Andrews Asylum for the Criminally Insane; idealistic about his future there, he hopes to effect change and really have an impact in his field. Instead, Bishop wanders into a nightmare when, after a string of unexplained patient deaths, he enters the cooler one night and meets The Harvester. Dr. Bishop quickly realizes that this hospital is not what it seems.