This report is the outcome of a comparative analysis of seven national investment cases from the region, and highlights key findings and recommendations for further action. The findings from this report and the Regional Expert Consultation on Developing Evidence-Based National HIV Investment Cases and Sustainability Plans held in December 2015 are expected to contribute to the knowledge base on how ESCAP Member States have developed national investment cases (NICs), and identify examples of best practice. The analysis was based primarily on a desk review of the investment cases of Bangladesh, Indonesia, Myanmar, Nepal (Investment Plan), the Philippines, Thailand and Viet Nam, with additional input from in-country respondents and from the Regional Expert Consultation.