We
have extensive expertise in experimental and microarray design. We
provide practical and impartial advice on best practices to help clients
maximize data quality and stay on budget. We can guide and support
through the entire project from microarray manufacturing, processing, reaction,
detection and quantification of data. Sample preparation, microarray format,
reaction/hybridization equipment, buffers, tools, positive/negative controls,
shipping and storage all have to work together to assure high quality data.

3.Capacity

A
single NanoPrint Microarrayer can produce more than 1,000 microarrays per day
and current processing throughput is hundreds of samples per day.
Microarrays we manufacture have good stability, can be shipped anywhere
in the world, and are very stable. Turnaround times matter, we are in
constant production in clean room level environments to assure prompt delivery
of high quality. Proteins amounts are dramatically lower than bead and
ELISA based platforms. 15 ug of protein can produce thousands of
microarrays.

4.Recommendation

References
can be provided so new customers can contact existing clients for unbiased
feedback. As mentioned above, our products and services have appeared in
thousands of scientific publications. We supply quality control
documentation required under ISO 13485 certification and work closely with our
clients to establish quality control metrics for specific projects.

5.Process

In
order to control quality, Arrayit manufactures our surface chemistry and
microarray manufacturing

technology.
We are innovators of microarray technology, not integrator of other
vendor’s platforms. However, if a client has their own
"biochip" technology such as a microfluidic device, sensor, reader or
other piece of the experimental design life cycle, we can identify
synergies and adapt our microarray manufacturing methods and expertise to these
projects.

Microarray
data quality is reported using very complete and detailed methods. TIF
image files used for quantification are created; spot finding work files are
created and saved so that there is a record of how the data was generated.
Additionally full reporting of all the quantified data points in the
microarray include:

• Block: block number

•
Column: spot column number

•
Row: spot row number

•
X: x-coordinate of the spot center in µm from the top left corner of the image

•
Y: y-coordinate of the spot center in µm from the top left corner of the image

•
Fxxx Median: spot pixels median (the median is not as sensitive to dust as the
mean value)

•
Fxxx SD: standard deviation of spot pixels

•
Fxxx |log Mean/Median|: absolute value of the logarithm of the spot Mean/Median
ratio. This indicates consistency between the two values mean and median, which
are normally very similar. If these values are very different, this parameter
tends to differ from 0. This is often indicative of dust affecting the mean
without affecting the median, or non-homogeneity in the spot.

•
Fxxx CV: spot standard deviation/mean ratio

•
Fxxx %Sat.: the percentage of spot pixels at wavelength xxx that have the
maximum 16-bit intensity value of 65535.

•
Circularity: Circularity measure. 100 is most circular, 0 is most non-circular.
As Mapix uses only circular arithmetic mean intensities wavelengths x1 and x2,
with the

• median
background intensity subtracted.

• Median
of Ratios (x1/x2): the median of pixel-by-pixel ratios of pixel intensities for
wavelengths x1 and x2, with the median background intensity subtracted. Ratios
greater

than
100 and less than 0.01 are excluded when calculating this value.

•
Mean of Ratios (x1/x2): the mean of the pixel-by-pixel ratios of pixel
intensities for wavelengths x1 and

•
x2, with the median background intensity subtracted. Ratios greater than 100
and less than 0.01 are excluded when calculating this value.

•
Ratios SD (x1/x2): the standard deviation of the log of pixel intensity ratios
for wavelengths x1 and x2. Ratios greater than 100 and less than 0.01 are
excluded when calculating this value.

•
Sum of Medians (x1/x2): the sum of the median intensities for wavelengths x1
and x2, with the median background intensity at each wavelength subtracted.

•
Sum of Means (x1/x2): the sum of the mean intensities for wavelengths x1 and
x2, with the median background intensity at each wavelength subtracted.

•
Log Ratio (x1/x2): log2 transform of the ratio of the medians for wavelengths
x1 and x2.

•
features, this value is always 100

•
Ratio of Medians (x1/x2): the ratio of the median intensities wavelengths x1
and x2, with the median

•
background intensity subtracted,

•
Ratio of Means (x1/x2): the ratio of the of the medians for wavelengths x1 and
x2.

Full
disclose of the work and work quality is provided, this is just no way to fake
it, the data is real and complete.

8. Environmental Control

All
our services work are performed in clean rooms, that includes microarray
manufacturing, processing and detection.

9. Security and Confidentiality

Our
business is projected by alarm systems and motion sensors. Data is
typically provided over the internet via confidential downloads, but other
methods can be used at the discretion of our clients. In most all cases
many confidential details of your experiment do not need to be known to us for
us to still provide a valuable service. Although some of our facilities are not
open to the public, our demonstration facilities are here to show our
clients how we perform our work.

10. Reduce Capital Spending.

Outsourcing
to Arrayit converts fixed costs into variable costs, since you play as you
play. This releases capital for investment elsewhere in your business, and
allows you to avoid large expenditures. Outsourcing can also make your firm
more attractive to investors, since you're able to pump more capital directly
into other R&D activities or revenue-producing activities such as sales and
marketing.

11. Increase Efficiency.

Companies
that do everything themselves have much higher research and development costs.
We provide an affordable cost structure and since we service many users we have
the economy of scale to give your organization a competitive advantage.

12. Reduce Labor Costs

Hiring
and training staff uses valuable time and money. These employees can be
difficult to manage since managers don't know and don't want to know anything
about microarrays, they just need the data. Microarray projects can be
expensive, and temporary employees in this area do not exist. Outsourcing lets
you focus your human resources where you need them most.

13. Speed

We have the
microarray resources to implement all major microarray applications in-house.
Our experience can bring your new microarray ideas and applications to reality
quickly. Tackling the microarray project in-house involves weeks or months to
hire the right people, train them, and provide the support they need.
Additionally, capital investments make the startup process even more difficult.
We have the technology in-house to make any type of microarray, from peptide,
to antigen, to antibodies, lysates and more...

14. Focus and Specialize

All
organizations have limited resources, and every project manager has limited
time and attention. Outsourcing to Arrayit shifts the focus from peripheral
activities toward work that that generates valuable data for your organization...the
reason we use microarray in the first place!

15. Take Advantage

We've been making
microarray for 15 years. No other firm can match the in-house expertise that we
have maintained over the years. Outsourcing gives your firm access to our vast
experience, economies of scale, efficiency, and expertise that that we have
built over many years. Since we make our own surface chemistry, microarrayers,
micro spotting devices and more...you don't have to buy it!

16. Reduce Risk

Every business
investment carries a certain amount of risk. Markets, competition, government
regulations, financial conditions, and technologies all change very quickly. We
assume and manage much of the risk for you, and we know how to avoid risk in
the microarray industry.

17.Peace of Mind

We're nice people
and we can make the process fun, not painful. Every time we think we've
got everything solved, a new application and challenge is presented to us.
Our longevity is a tribute to our ability to solve problems and the
reality is life science and experimental design is that problems will arise.
Life is too short and this technology is too good not to be excited about
it.