Lauriad for Oral Thrush

People with oral candidiasis will take either Lauriad (miconazole) tablets once a day or clotrimazole troches 5x a day for 2 weeks. Participants must be 18 or older and be on stable HAART for at least 2 months.

Transacin (NGX-4010) for Peripheral Neuropathy

People with HIV who have peripheral neuropathy will use either Transacin (capsaicin) patches or placebo patches for 30 or 60 minutes a day for 3 months. Participants must be 18 or older and have had pain in both feet for at least 2 months.

Pregabalin for Peripheral Neuropathy

People with HIV who have peripheral neuropathy will take either pregabalin (Lyrica) or a placebo (dummy pill) for 3 months. Participants must be 18 or older and have had pain in their hands or feet for at least 3 months.

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KP-1461 for Resistant HIV

People with HIV that is resistant to at least 3 of the 4 classes of HIV drugs will stop all HIV drugs for 6 weeks and then take KP-1461 (an experimental NRTI) or a placebo pill twice a day for 2 weeks. Participants must be 18 to 60 years old, have a CD4 count above 100 and a viral load between 2,500 and 50,000.

IMPACT: Reyataz Resistance

People who have developed resistance to Reyataz will come in for one day of blood tests to study the I50L mutation.

HIV Treatment Decision-Making Study

African-Americans who have not taken HIV drugs will complete a one-hour survey on a laptop computer and receive a $25 debit card. Participants must be 18 or older. Contact Perion Smith at 212-924-3934 ext. 105.

DUET: TMC 114 & 125 for Drug-Resistant HIV (Closed to Enrollment)

People who are resistant to PIs and NNRTIs will take TMC125 (a new NNRTI) or a placebo (dummy) pill. Everyone will also take TMC114 (a new PI) with Norvir and other anti-HIV drugs. Participants must be 18 or older and have a viral load over 5,000.

TH9507 for Lipodystrophy (Closed to Enrollment)

People who have excess abdominal fat and who are taking anti-HIV drugs will take either TH9507 (an experimental growth hormone releasing factor) or a placebo for 26 weeks.

Maraviroc for Drug-Resistant HIV (Closed to Enrollment)

People who have taken anti-HIV drugs from three of the four classes of drugs will either take maraviroc (an experimental HIV attachment inhibitor) or placebo with an optimized regimen of anti-HIV drugs for 11 months.

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