” These findings have direct relevance to our understanding of bipolar disorder, where genetic insults increase protein kinase C signaling which may be associated with a loss of prefrontal grey matter and behavioral control.”

“‘We found an increased risk of death in patients who report more depressive symptoms than others and also in patients who have been diagnosed with a depressive disorder compared to patients who have not,’ said Satin. In the combined studies, the death rates were up to 25 percent higher in patients experiencing depressive symptoms and 39 percent higher in patients diagnosed with major or minor depression.”

“Ketamine acutely reduced suicidal thoughts when patients were assessed 24 hours after a single infusion. This reduction in suicidality was maintained when patients received repeated doses over the next two weeks.”

“Teenagers who experience mild depression are more likely to suffer from major depression, eating disorders, and anxiety disorders as adults, researchers say. The investigators say their finding suggests that it’s vital to provide support and assistance to teens who show two or more persistent depression symptoms.”