Clinical Trial Details

If you are a patient or a caregiver and would like to learn more our cancer clinical trials
call toll-free 1-855-702-8222 (adult trials) or 1-773-702-6808 (pediatric trials) or
email cancerclinicaltrials@bsd.uchicago.edu.

This randomized phase II trial studies how well metformin hydrochloride and combination
chemotherapy works in treating patients with stage III-IV ovarian, fallopian tube, or
primary peritoneal cancer. Drugs used in chemotherapy, such as carboplatin, paclitaxel and
docetaxel, work in different ways to stop the growth of tumor cells, either by killing the
cells, by stopping them from dividing, or by stopping them from spreading. Metformin
hydrochloride may help carboplatin, paclitaxel and docetaxel work better by making tumor
cells more sensitive to the drugs. Studying samples of blood and tissue in the laboratory
from patients receiving metformin hydrochloride may help doctors learn more about the
effects of metformin hydrochloride on cells. It may also help doctors understand how well
patients respond to treatment. Giving metformin hydrochloride together with combination
chemotherapy may kill more tumor cells.