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Description

Voriconazole is a triazole antifungal compound developed specifically to target species of Aspergillus, although it displays broad spectrum activity against other fungi as well. Voriconazole inhibits 14α sterol demethylase (14αSD). This compound also exhibits immunomodulatory activity, as it increases levels of toll-like receptor 2 (TLR2) and TNF-α and stimulates translocation of NF-κB in monocytes.