Scleroderma

Scleroderma Overview

Scleroderma, or systemic sclerosis, is a rare autoimmune disease that can cause the connective tissue in the skin — and sometimes the internal organs — to thicken and stiffen.

UPMC has a rich history in the treatment of scleroderma. Our experts have made significant contributions to understanding the epidemiology, clinical and laboratory features, and natural history of this disease.

We also work closely with esophageal experts in UPMC’s Division of Gastroenterology and the UPMC Heart, Lung, and Esophageal Surgery Institute, because of the high prevalence of esophageal dysmotility, or loss of usual movement, and gastroesophageal reflux (GERD) in people with scleroderma.

There is also a growing body of evidence supporting an association between these esophageal disorders and the development of pulmonary fibrosis.

Treatment options for scleroderma

Surgical lung biopsy — UPMC specialists at the Simmons Center work closely with our expert thoracic surgeons and pulmonary pathologists on those cases that require a surgical lung biopsy to help formulate a management plan.

Lung transplantation — For people with progressive lung disease that respond poorly to medical therapy, lung transplantation may be an option.