Postdoctoral Training

Research Interests

Development of early diagnosis strategy for human cancers

Identification of cancer-specific biomarkers

Mechanisms drive cancer metastasis

Biography

Yi-Lin Yang, Ph.D. is an Assistant Adjunct Professor of Surgery at UCSF and a member of the Thoracic Oncology Laboratory at UCSF. She received her Ph.D. degree in Comparative Biomedical Sciences from Tufts University in 2010 and her M.S. degree in Biochemistry and Molecular Biology from Oregon Health & Science University in 2004. Upon the completion of her post-doctoral training in San Francisco VA Medical Center, Dr. Yang joined the Thoracic Oncology Laboratory of UCSF in 2012.

Research Overview

Dr. Yang's research focuses on understanding the biological and molecular mechanisms in human lung cancer and malignant pleural mesothelioma. Her studies have shown the significance of Wnt2 and Notch1 signaling in human lung cancer and in human malignant pleural mesothelioma, and blocking the signaling inhibits tumor growth. She has also established a transgenic mouse model of mesothelioma, an orthotropic malignant mesothelioma model, and brain metastasis models of human lung cancer. These animal models are useful tools for testing potential therapies in human lung cancer and mesothelioma, including immunotherapy.

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