I have no idea how much prominence the WL2 devs plan to give to crafting (this is the kind of mechanic that could potentially deserve an update all for itself), but we know that it's in and that there are skills dedicated to it.

Again, trying to keep this brief and pointed (as much as I can anyway): Will we be able to craft on the road, or will we need to go to specific locations (like the New Vegas crafting benches)? Will we need to keep tool with us to be able to craft? Obviously we will need specific ingredients, but what about recipes? Will we have to find them or will crafting recipes pop up as soon as we'll hit the right level in the crafting skill? Will we only be able to craft utility items or also unique items that are not available elsewhere?

We are currently thinking you will need to go to specific locations for most difficult crafting. For example, when using the weapon smithing skill, you will mostly need to be at a bench. There are elements of crafting that can be done on the road though. I'm being vague on purpose as there are some interesting elements to it that I don't want to reveal right now.

Crafting recipes can be learned as well as available when you hit specific skill levels with that particular skill. There will be unique items that you can craft that aren't available for purchase.