• axonal spheroids are detected in pons and cortical areas at 6 months of age and in the spinal cord mostly along the anterior margin of the ventral horn and less frequently in the intermediolateral and dorsal horn

• at 10 and 14 months of age axonal spheroids are detected in pons, cortex, medulla, midbrain, hippocampus, corpus callosum and striatum

• larger axonal varicosities are seen in the medulla at 14 months of age

• large axonal dilatations are localized in white matter fiber tracts in close vicinity to the ventral horn in the spinal cord