BRENTWOOD — A 50-year-old Rochester man was seriously injured Tuesday morning when his pickup truck crossed the center line on Route 125 in Brentwood and struck a tractor-trailer heading the opposite way.

New Hampshire State Police said Michael Starkey was flown by medical helicopter to Brigham and Women’s Hospital in Boston following the collision, which occurred at about 7:17 a.m.

Starkey was driving a 2000 Ford Ranger south on Route 125 when the truck crossed into the northbound lane and collided with a 1986 Freightliner tractor-trailer, according to an announcement from New Hampshire State Police.

A state police official who was reached later in the afternoon had no further information about Starkey’s condition or the cause of the crash. A staff member at Brigham and Women’s hospital said Starkey was not being treated there.

William Valpone, the 45-year-old driver of the tractor-trailer, suffered minor injures. Valpone, of Newbury, Mass., was treated at the scene.

Route 125 was closed in the area of North and Middle roads for approximately three hours. Troopers from State Police Troop A assisted at the scene. Police and firefighters from Brentwood and Epping also responded, as did officers from the Fremont and Kingston police departments, the Rockingham County Sheriff’s Department and the New Hampshire State Police Commercial Vehicle Enforcement Unit.

Police are still investigating the circumstances of the crash. Anyone with pertinent information is asked to contact Trooper Michael Shupe at 603-223-8490.