I took Metagenics UltraInflamX for almost a decade. It was primarily curcumin and eased my allergies and FM pain. After taking it for so long, I eventually developed an allergy to curcumin. Story of my life.

Sue,
I have been taking longvida optimized curcumnin fot three weeks with excellent results......(I have had cfs since 1987 and xmrv+).... two weeks ago I added one Effervescent N-Acetylcysteine 900 mg found it did give me more energy, but I developed flu symptoms. Keep us posted on your results.

I've been trying some "Curamin" from Teitelbaum's web site, vitality101. It's supposed to be a strong formulation but I did not research the strength of other brands and just took their word for it. I have severe chronic pain so it's hard to tell for sure but I think it does seem to help some when I can remember to take it and so far I have not had any adverse reactions to it which is saying something since many meds and suppliments don't agree with me. I hope it works for you.

The types of amyloid proteins Dr. Baraniuk found in chronic fatigue syndrome (ME/CFS) patients are unique to the brain. These same general types of proteins are also found in neurodegenerative diseases such as Alzheimer’s and Down’s syndrome.

Yes thank you I am interested in amyloid proteins and amyloid formation and I shall look forward to reading Cort's article

I just had a quick read about the theory about low carnosine levels in CFS and I am not sure if this has been discussed before on the forum but it is interesting to note that L-Carnosine was found to be beneficial to children with autism spectrum disorders and/or epilepsy

CNDP1 (carnosine dipeptidase) degrades carnosine, an amino acid that’s highly concentrated in brain and muscle tissues. Carnosine has a number of different functions; it’s a free radical scavenger and increases corticosterone levels and reduces glycolysis. Corticosterone is an intermediate in the steroid pathway from pregnenalone to aldosterone – an interesting finding given the hormonal questions regarding ME/CFS. Presumably the version of the gene Dr. Baraniuk has found is more active than usual at degrading carnosine and thus could lead to reduced carnosine levels. Low carnosine levels could, then, conceivably contribute in increased oxidative stress and hormonal problems seen in ME/CFS. This, of course, is just a theory and is very preliminary at this point.

Use of L-Carnosine in autism

Use of L-Carnosine in autism was pioneered by Dr. Michael Chez, a pediatric neurologist from Chicago. Dr. Chez theorized that L-Carnosine stimulates the front areas of the brain, providing increased activity, leading to overall improvements in level of functioning. More and more research shows that the frontal lobes and temporal lobes in the brain control emotion, epileptic activity, cognitive, expressive speech, and abstract thinking. It also rejuvinates old, dying cells restoring them to youthful appearance - hence it is a key anti-aging supplement as well.

Carnosine, Autism, and Seizure Disorders

In a double-blind study conducted by Dr. Chez, L-Carnosine was found to be beneficial to children with autism spectrum disorders and/or epilepsy. Participants in the clinical trial who were given L-Carnosine experienced significant improvements compared to those taking a placebo in the following areas: language, auditory processing socialization, awareness of surroundings, fine motor planning and expressive language. Improvements were observed between 1-8 weeks into treatment, with a 90 percent success rate.

Participants taking L-Carnosine showed improved behavior and communication by 16 percent and social interaction improved by 27 percent! In just four weeks, parents reported an overall improvement that more than doubled through the length of the study. To view a summary of the clinical trial, please click here.

Dr. Chez also theorized that all autistic children are dyslexic and that distortion of sensory input (touch, taste, hearing, sight) that autistic children experience are forms of dyslexia. We have anecdotal evidence from customers of all ages that their dyslexia improves or completely disappears when they supplement with Carnosine, including a young lady whose handwriting, reading skills, and grades dramatically improved in after taking Liquid Carnosine Plus over a two-month period. Dr. Chez's study also showed the reading ability took a leap when taking Carnosine.

I took NAC for a couple of years with no noticeable effects, so I stopped after reading it could allow mercury to pass into my brain.

Curcumin helps reduce my Fibro pain, and has worked miracles for my husband, who has a regional pain syndrome from doing hard physical work all his life. Curcumin enabled him to cut his narcotics in half after only one week, and that has continued for 3 months now. We use Jarrow brand, 500 mgs. daily.