Previous HGNC Symbols for NAA15 Gene

Previous GeneCards Identifiers for NAA15 Gene

Summaries for NAA15 Gene

Entrez Gene Summary for NAA15 Gene

N-alpha-acetylation is among the most common post-translational protein modifications in eukaryotic cells. This process involves the transfer of an acetyl group from acetyl-coenzyme A to the alpha-amino group on a nascent polypeptide and is essential for normal cell function. This gene encodes the auxillary subunit of the N-terminal acetyltransferase A (NatA) complex. [provided by RefSeq, Jan 2017]

GeneCards Summary for NAA15 Gene

NAA15 (N(Alpha)-Acetyltransferase 15, NatA Auxiliary Subunit) is a Protein Coding gene.
Diseases associated with NAA15 include Ogden Syndrome and Retinitis Pigmentosa 75.
Among its related pathways are Mesodermal Commitment Pathway.
GO annotations related to this gene include poly(A) RNA binding and N-acetyltransferase activity.
An important paralog of this gene is NAA16.

UniProtKB/Swiss-Prot for NAA15 Gene

Auxillary subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal) acetyltransferase activity. The NAT activity may be important for vascular, hematopoietic and neuronal growth and development. Required to control retinal neovascularization in adult ocular endothelial cells. In complex with XRCC6 and XRCC5 (Ku80), up-regulates transcription from the osteocalcin promoter.

Graphical View of Domain Structure for InterPro Entry

No data available for
UniProtKB/Swiss-Prot
for NAA15 Gene

Function for NAA15 Gene

Products:

Molecular function for NAA15 Gene

UniProtKB/Swiss-Prot Function:

Auxillary subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal) acetyltransferase activity. The NAT activity may be important for vascular, hematopoietic and neuronal growth and development. Required to control retinal neovascularization in adult ocular endothelial cells. In complex with XRCC6 and XRCC5 (Ku80), up-regulates transcription from the osteocalcin promoter.

SOURCE GeneReport for Unigene cluster for NAA15 Gene:

mRNA Expression by UniProt/SwissProt for NAA15 Gene:

Tissue specificity:Expressed at high levels in testis and in ocular endothelial cells. Also found in brain (corpus callosum), heart, colon, bone marrow and at lower levels in most adult tissues, including thyroid, liver, pancreas, mammary and salivary glands, lung, ovary, urogenital system and upper gastrointestinal tract. Overexpressed in gastric cancer, in papillary thyroid carcinomas and in a Burkitt lymphoma cell line (Daudi). Specifically suppressed in abnormal proliferating blood vessels in eyes of patients with proliferative diabetic retinopathy.

No data available for
UniProtKB/Swiss-Prot and
Genatlas
for NAA15 Gene

Publications for NAA15 Gene

Proteomics analyses reveal the evolutionary conservation and divergence of N-terminal acetyltransferases from yeast and humans.(PMID: 19420222)Arnesen T … Gevaert K(Proceedings of the National Academy of Sciences of the United States of America 2009)232260