There is a total of 10 Vacuum Bots to destroy:
5 in Minerva’s Den
5 in OperationsDO NOT take the elevator to Operations if you have not destroyed all the 5 bots in Minerva’s Den. There is NO way to come back.

The Lancer is a new type of Big Daddy unique to the Minerva's Den DLC. The Lancer's main form of attack is its Ion Laser, which will provide constant damage for as long as you're caught in it. As well as that it also has another move called the Ion Flash, which will temporarily blind you if you see it. Despite all of this, he does not deal as much damage as the other types of Big Daddies, so if you can finish him off quickly, you will not suffer much damage from it. He also suffers from the same weaknesses the other Big Daddies do, so whatever strategy from armor-piercing rounds, to using security cameras against all work very well against Lancers. Security Bots can easily be found all throughout Minerva's Den, which can easily be hacked. They are an absolutely huge help against Lancers, as they are immune to it's Ion Flash.

Using the Gravity Well Plasmid that is also new to Minerva's Den, you can lock a Lancer in place. Doing so will prevent him from ever being able to from moving around and effectively using Ion Flash against you, which will make him much easier to take down.

Just like in the main game, you will encounter several Little Sisters throughout Minerva's Den. There are a total of six Little Sisters, three within Minerva's Den, and three within Operations. For the achievement, you must deal with all six of the Little Sisters found through the DLC. It doesn't matter whether you Save or Harvest all or some of them, so long as you deal with all of them.

If you still need to rescue a Sister, but she doesn’t appear anywhere on the map, walk around the area until you see a Lancer. Follow him to a ventilation hole where he will call a Little Sister, were you will then be able to rescue/harvest her.

Note: If you leave Minerva's Den or Operations and you haven't rescued/harvested the Sisters three Little Sisters here, you WON'T be able to come back!

Spitfire is a mini-game that is new to Minerva's Den, and can be played during the game's second level, Operations. When you reach the room with four visible consoles, go up the stairs to your right and through the door. Go through the next door and up some more stairs. In front of you there will be a TV screen. Press to play the Spitfire game.

To get the achievement, you will have to get a total of 9999 points with only 4 lives.
Use the to aim, and or to shoot your enemies.