In theory: yes! I've written a version of Verve earlier, which allowed the use of Multi Touch with how ever many touches your system supports. It's somewhat fun to paint with all 10 fingers, but a bit silly, too, unless you somehow know what you're doing, haha. In your case, I imagine something awesome would come out!However, 2 pens won't work, because I don't think Wacom or any tablet supports the use of two pens?!