1. A composition comprising amoxicillin and potassium clavulanate in a dosage of 2000 mg of amoxicillin and 125 mg of potassium clavulanate, wherein the composition is in a
solid form and comprises a first release phase and a second release phase; the first release phase comprising potassium clavulanate and a first amount of the amoxicillin; and the second release phase comprising a second amount of the amoxicillin in the
form of a soluble salt at about 60 80% of the second phase, a pharmaceutically acceptable organic acid in a molar ratio of 50:1 to 1:5 (amoxicillin to organic acid), and a reduced amount of a pharmaceutically acceptable release retarding polymer which is
xanthan gum at about 1 5% of the second phase; wherein the composition provides a mean maximum plasma concentration (Cmax) of amoxicillin of at least 12 .mu.g/ml.

3. A composition according to claim 1 wherein the amoxicillin in the first release phase is amoxicillin trihydrate.

4. A composition according to claim 1 wherein the soluble salt of amoxicillin in the second release phase is sodium amoxicillin.

5. A composition according to claim 4 wherein the sodium amoxicillin is crystallized sodium amoxicillin.

6. A composition according to claim 1 wherein the composition provides an Area under the Curve (AUC) value of amoxicillin which is at least 80% of that of the same amount if taken as an immediate release formulation over the same dosage period.

7. A composition according to claim 1 wherein the composition provides a mean plasma concentration of amoxicillin of at least 4 .mu.g/ml for at least 4.4 hours.

8. A composition according to claim 1 wherein the ratio of amoxicillin in the first and second release phases is from 3:1 to 1:3.

9. A composition according to claim 1 wherein the ratio of amoxicillin in the first and second release phases is from 3:1 to 2:3.

10. A composition according to claim 1 wherein the ratio of amoxicillin in the first and second release phases is from 2:1 to 2:3.

11. A composition according to claim 1 wherein the ratio of amoxicillin in the first and second release phases is from 3:2 to 1:1.

12. A composition according to claim 1 wherein the solid form is a tablet.

13. A composition according to claim 12 wherein the tablet is a bilayer tablet.

14. A composition according to claim 1 wherein the first release phase comprises essentially all the potassium clavulanate.

15. A composition according to claim 1 wherein the release of amoxicillin has a biphasic profile.

16. A method for treating a bacterial infection in a patient in need thereof comprising administering to said patient an effective amount of a formulation according to claim 1.

17. A method according to claim 16 in which the bacterial infection is caused by at least one of the organisms S. pneumoniae, H. influenzae, and M. catarrhalis.

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