TY - JOUR
T1 - You Should Have the Same Area Counts
JF - The Journal of Applied Laboratory Medicine: An AACC Publication
JO - Jrnl App Lab Med
SP - 767
LP - 770
M3 - 10.1373/jalm.2016.022079
VL - 1
IS - 6
AU - Yaman, Ali
AU - Gerin, Fethullah
AU - Baykan, Ozgur
AU - Sirikci, Onder
AU - Haklar, Goncagul
Y1 - 2017/05/01
UR - http://jalm.aaccjnls.org/content/1/6/767.abstract
N2 - Mass spectrometry is a sensitive technique used to detect, identify, and quantify molecules based on their m/z. High-performance liquid chromatography (HPLC)4 is a common separation technique used before analysis of biological samples by LC-MS/MS. LC-MS/MS is preferred over immunoassay for therapeutic drug monitoring of immunosuppressive drugs due to its specificity and sensitivity in detecting analytes in liquid and nonvolatile samples. However, time-consuming sample preparation and interferences resulting from ion suppression are among the disadvantages of LC-MS/MS because they can compromise or invalidate results. Also, although the instruments used are more robust, computer-interfaced, user-friendly, and easier to maintain compared with decades ago (1), their technical complexity leads to difficulties in troubleshooting and can be intimidating to laboratorians. Creating exhaustive system checklists …
ER -