Schlafly created the wiki-based Conservapedia in November 2006 to counter what he perceived as a liberal bias present in Wikipedia.[19] He felt the need to start the project after reading a student's assignment written using Common Era dating notation, rather than the Anno Domini system that he preferred. Although he was "an early Wikipedia enthusiast", as reported by Shawn Zeller of Congressional Quarterly, Schlafly became concerned about perceived bias after Wikipedia editors repeatedly undid edits to the article about the 2005 Kansas evolution hearings.[20] Schlafly expressed hope that Conservapedia would become a general resource for American educators and a counterpoint to the liberal bias that he perceived in Wikipedia. The Conservapedia project has been met with generally negative reception from liberal and conservative critics alike for bias and inaccuracies.[21][22][23]

Richard Lenski, an evolutionary biologist[25] who completed an experiment on evolution which showed speciation of E. coli bacteria over 10,000 generations, was engaged in correspondence by Schlafly about the results in 2008. Conservapedia supports creationism and objects to evolution, so Schlafly disputed that bacteria could evolve via beneficial mutations. The correspondence was commented on across the Internet. Schlafly was criticized by Lenski on sites such as Ars Technica for not reading Lenski's paper properly, for not understanding the experimental data he requested, and for not taking notice of people on Conservapedia itself who considered the paper well researched.[26]