Dre Kirkpatrick, CB, Cincinnati Bengals

Brian Spurlock-USA TODAY Sports

Dre Kirkpatrick can't catch a break. Injuries robbed him of much of his rookie campaign, and now the Cincinnati Bengals confirmed the cornerback suffered a strained hamstring and wouldn't return against the Pittsburgh Steelers.

Russell Okung, OT, Seattle Seahawks

Jeff Hanisch-USA TODAY Sports

Russell Wilson better have his head on a swivel. An injury forced his blindside protector, starting Seattle Seahawks left tackle Russell Okung, to the locker room according to NBC Sports' Michele Tafoya.

TAFOYA: Okung going back for x-rays on his left foot. His return is questionable at this time.

Before the first quarter was in the books in Week 2 against the Seattle Seahawks, however, Williams was injured after getting cut by an offensive lineman on a running play. He limped off the field, as noted by Matt Maiocco of CSN Bay Area:

Ian Williams is being helped off the field, favoring his left lower leg.

The Broncos were already thin on defense before Ihenacho's injury. If he's out for any length of time, then it'll put more pressure on Payton Manning and his offense to continue putting points up in bunches to overcome a suspect secondary on defense.

After injuring his knee in the second quarter, Bush attempted to come back into the game, but his knee didn't hold up. As noted by Dave Birket of the Detroit Free Press, Bush was seen on the sidelines without his helmet anywhere near him. Birkett later tweeted that Bush looked to be done for the day:

Reggie Bush does not have his helmet on or in his hands on the sideline.

As we saw from Bush in Week 1, his ability to make game-changing plays as a runner and a receiver puts stress on opposing defenses. With Calvin Johnson occupying two and sometimes three defenders deep, Bush can gash defenses underneath.

Fitzgerald is one of the most talented receivers in the NFL and the Cardinals need him on the field, so it's imperative that he get healthy soon. Even if it means sitting him out a week or two, it might be time for shelve him until he's 100-percent healthy.

Maurice Jones-Drew, RB, Jacksonville Jaguars

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After missing the entire 2012 season with a foot injury, Jacksonville Jaguars running back Maurice Jones-Drew hoped to rebound with a huge season in 2013.

But the former league-leading rusher from 2011 exited the game in Week 2 against the Oakland Raiders with an ankle injury and is questionable to return, as noted by Vic Tafur of the San Francisco Chronicle:

Through two games, the veteran has caught 20 passes for 222 yards, helping Houston open the season with two wins. Needless to say, losing him for any amount of time would be challenging for Matt Schaub and the Texans.

Malcom Floyd, WR, San Diego Chargers

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The scariest moment of Week 2 occurred when Malcom Floyd was struck in the head by DeMeco Ryans..

UPDATE: by Jesse Reed at 5:38 p.m. ET on Monday, Sept. 16

Floyd was able to fly home with the team on Sunday, but he's still out indefinitely, as noted by Ian Rapoport of NFL Network. He's seeking a second opinion on his neck, which will be protected by a brace for at least a week:

#Chargers WR Malcom Floyd, who was carted off, getting a 2nd opinion. But out indefinitely, source says. In a neck brace for at least a week

Though it was first reported that Heyward-Bey had injured his ribs, Colts head coach Chuck Pagano told reporters that he actually injured his shoulder, as noted by Phillip B. Wilson, who also noted the receiver has an MRI scheduled:

With tight end Dwayne Allen struggling with his own injury, this puts more pressure on second-year players Coby Fleener and T.Y. Hilton to step up and perform. Given Andrew Luck's abilities as a passer, however, this team should be fine for the time being on offense.

After suffering a thumb injury in the fourth quarter against the Baltimore Ravens, Weeden told reporters that it was too early to tell if he'd be able to play in Week 3, as noted by Mary Kay Cabot of the Plain Dealer:

#Browns Weeden (sprained thumb) said it's too early to tell if he'll be back for next week's game in Minnesota.

This puts even more pressure on the youngsters up front to put pressure on opposing quarterbacks and to stuff the run, as Branch is one of Oakland's top defensive backs and one of its most talented players.

Ray Rice, RB, Baltimore Ravens

The Baltimore Ravens cannot afford another injury to a skill-position player on offense this year after losing Dennis Pitta.

UPDATE: by Jesse Reed on Sunday, Sept. 15, at 4:45 p.m. ET

After leaving the game against the Cleveland Browns, Ray Rice and the Ravens received a bit of good news. As noted by Jeff Zrebiec of the Baltimore Sun, Rice suffered a hip flexor strain, but he's not scheduled for an MRI, which is a good sign:

Chykie brown has a knee strain. Ray Rice has hip flexor strain. Not scheduled for MRI at this point.

Unfortunately, Pro Bowl running back Ray Rice was forced out of the game against the Cleveland Browns with a hip injury, as noted by the Ravens. It was reportedly a non-contact injury, as noted by Bleacher Report's Will Carroll:

Ray Rice is up and limps off to the sideline, surrounded by doctors. He's headed to the locker room.

Losing Rice for any amount of time could be catastrophic to a team that is already struggling to move the ball effectively on offense. Bernard Pierce will start in his stead, and though he's a phenomenal runner, he isn't as dynamic catching passes out of the backfield.

Without Jackson in the lineup, Jacquizz Rodgers and Jason Snelling will be counted on to provide balance in the running game. But neither of them is as accomplished an inside runner as Jackson, which means the Falcons will likely rely more on the passing game.

Sean Weatherspoon, LB, Atlanta Falcons

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The Falcons suffered a rash of minor injuries on Sunday.

Sean Weatherspoon was one of the starters who got banged up during the game against the St. Louis Rams. He suffered a "foot strain," as noted by Mike Garafolo of Fox Sports, and will undergo more tests on Monday:

...LB Sean Weatherspoon's injury was preliminarily labeled a "foot sprain" that wasn't believed to be serious. More tests were coming today.

Brandon Meriweather, S, Washington Redskins

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After knocking Eddie Lacy out of the game, Washington Redskins safety Brandon Meriweather also was injured.

Meriweather was hurt after helmet-to-helmet contact with Green Bay Packers running back James Starks, as noted by Mike Vandermause of the Green Bay Press-Gazette, and the Redskins confirmed that he's out of the game:

Brandon Merriweather injured after helmet to helmet contact with James Starks.

Washington's secondary was already in deep trouble before Meriweather's departure. It was a point of weakness in last year's squad, and his absence puts more pressure on the front seven to generate sacks and quarterback hurries.

Donald Thomas, OG, Indianapolis Colts

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The Indianapolis Colts signed offensive guard Donald Thomas as a free agent this spring to start at left guard. The team desperately needed an upgrade at the position, and Thomas was looking decent to start the season.

This is an injury that will likely keep him out the rest of the season, which means the Colts need to get creative the rest of the way in 2013 in order to keep quarterback Andrew Luck from getting pressured up the middle.