GREMLIN Results:
Residue pairs sorted by strength in covariance:Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

i

j

Raw Score

Scaled Score

5_I

12_I

0.21838

2.210

3_V

19_A

0.21046

2.130

31_Y

35_R

0.17599

1.781

63_L

95_N

0.16018

1.621

31_Y

34_L

0.1453

1.471

79_E

106_Q

0.14258

1.443

79_E

103_A

0.14154

1.433

44_P

63_L

0.14099

1.427

25_L

29_V

0.13788

1.396

32_L

37_L

0.13645

1.381

66_G

98_L

0.1327

1.343

10_Y

67_L

0.13151

1.331

47_V

80_K

0.13124

1.328

7_W

24_L

0.12961

1.312

23_L

32_L

0.12807

1.296

92_P

95_N

0.12535

1.269

70_L

102_A

0.12446

1.260

4_L

13_E

0.12434

1.259

101_R

105_A

0.12365

1.252

84_K

90_D

0.12335

1.249

4_L

11_R

0.12297

1.245

25_L

33_L

0.12231

1.238

2_Y

13_E

0.11993

1.214

61_R

90_D

0.11889

1.203

55_R

85_A

0.11774

1.192

27_F

31_Y

0.11536

1.168

99_A

102_A

0.11419

1.156

42_S

45_S

0.11407

1.155

20_L

40_L

0.11388

1.153

59_A

85_A

0.11197

1.133

72_E

101_R

0.11189

1.133

5_I

21_I

0.11165

1.130

40_L

61_R

0.11142

1.128

16_L

31_Y

0.11107

1.124

59_A

89_S

0.11077

1.121

62_A

85_A

0.11053

1.119

5_I

19_A

0.11048

1.118

2_Y

72_E

0.11031

1.117

71_A

107_G

0.1101

1.114

62_A

71_A

0.10991

1.112

66_G

101_R

0.10935

1.107

57_R

94_L

0.10901

1.103

25_L

28_V

0.10899

1.103

39_R

50_W

0.10897

1.103

15_S

80_K

0.10842

1.097

66_G

82_L

0.10792

1.092

26_L

84_K

0.10628

1.076

27_F

80_K

0.10605

1.073

69_A

74_D

0.10596

1.073

20_L

29_V

0.10563

1.069

14_T

18_V

0.10536

1.066

17_W

51_R

0.10404

1.053

43_L

58_K

0.10382

1.051

77_R

81_L

0.10348

1.047

56_R

65_R

0.10345

1.047

26_L

41_L

0.10323

1.045

72_E

102_A

0.10315

1.044

37_L

40_L

0.103

1.043

25_L

102_A

0.10292

1.042

6_S

9_G

0.10183

1.031

82_L

98_L

0.10183

1.031

28_V

32_L

0.10042

1.016

66_G

78_A

0.10017

1.014

86_A

92_P

0.09939

1.006

93_L

96_Y

0.09931

1.005

40_L

76_Q

0.09913

1.003

33_L

37_L

0.0991

1.003

20_L

52_R

0.09888

1.001

105_A

108_D

0.0986

0.998

4_L

15_S

0.09844

0.996

4_L

19_A

0.09721

0.984

25_L

32_L

0.09661

0.978

30_L

33_L

0.09639

0.976

73_G

92_P

0.0963

0.975

7_W

98_L

0.09582

0.970

68_I

72_E

0.09581

0.970

34_L

41_L

0.09543

0.966

3_V

15_S

0.09424

0.954

29_V

32_L

0.09388

0.950

28_V

94_L

0.09299

0.941

68_I

107_G

0.09294

0.941

11_R

74_D

0.09278

0.939

62_A

82_L

0.09238

0.935

35_R

38_R

0.09229

0.934

9_G

31_Y

0.0922

0.933

86_A

99_A

0.09179

0.929

27_F

30_L

0.09163

0.927

5_I

29_V

0.09148

0.926

7_W

84_K

0.09142

0.925

32_L

36_L

0.09098

0.921

28_V

40_L

0.09085

0.920

70_L

97_L

0.0906

0.917

37_L

41_L

0.09042

0.915

55_R

69_A

0.0901

0.912

23_L

27_F

0.08972

0.908

9_G

14_T

0.08962

0.907

92_P

99_A

0.08957

0.907

45_S

52_R

0.08957

0.907

72_E

99_A

0.08949

0.906

16_L

97_L

0.0892

0.903

12_I

86_A

0.08894

0.900

71_A

95_N

0.0889

0.900

36_L

58_K

0.08812

0.892

22_L

30_L

0.08758

0.886

7_W

74_D

0.08746

0.885

92_P

102_A

0.08708

0.881

49_R

53_R

0.08691

0.880

57_R

84_K

0.08583

0.869

14_T

65_R

0.08582

0.869

68_I

101_R

0.08524

0.863

13_E

21_I

0.08498

0.860

10_Y

20_L

0.08492

0.860

30_L

68_I

0.08491

0.859

46_R

49_R

0.08412

0.851

23_L

37_L

0.08407

0.851

64_S

97_L

0.08389

0.849

44_P

94_L

0.08386

0.849

18_V

44_P

0.08386

0.849

18_V

22_L

0.08346

0.845

4_L

47_V

0.08327

0.843

53_R

88_L

0.08321

0.842

32_L

65_R

0.08286

0.839

19_A

31_Y

0.08266

0.837

19_A

45_S

0.08266

0.837

27_F

34_L

0.08259

0.836

82_L

96_Y

0.08116

0.821

68_I

71_A

0.08081

0.818

66_G

75_W

0.08068

0.817

7_W

105_A

0.08038

0.814

5_I

30_L

0.08025

0.812

71_A

92_P

0.07942

0.804

79_E

95_N

0.07938

0.803

68_I

85_A

0.07917

0.801

32_L

61_R

0.07903

0.800

29_V

57_R

0.0789

0.799

83_A

102_A

0.07852

0.795

30_L

108_D

0.07823

0.792

9_G

25_L

0.07806

0.790

81_L

92_P

0.07788

0.788

40_L

43_L

0.07749

0.784

28_V

31_Y

0.07706

0.780

24_L

32_L

0.07651

0.774

4_L

82_L

0.07648

0.774

9_G

27_F

0.07604

0.770

36_L

45_S

0.07589

0.768

68_I

92_P

0.07581

0.767

69_A

101_R

0.07547

0.764

29_V

56_R

0.07536

0.763

72_E

86_A

0.07523

0.761

45_S

76_Q

0.07511

0.760

64_S

101_R

0.07483

0.757

16_L

19_A

0.07482

0.757

22_L

103_A

0.07439

0.753

29_V

45_S

0.07435

0.753

14_T

43_L

0.07406

0.750

10_Y

27_F

0.07398

0.749

55_R

101_R

0.07393

0.748

55_R

102_A

0.07335

0.742

20_L

31_Y

0.07324

0.741

38_R

97_L

0.07321

0.741

60_Q

97_L

0.07308

0.740

7_W

79_E

0.07301

0.739

Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.

HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits: Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)