Researchers working with a mouse model have determined that the Argonaute 2 (Ago2) protein intervene RNA silencing, which regulates both intrinsic energy production and consumption and disturbs energy metabolism in the development of obesity. Argonaute proteins are the catalytic element of the RNA-induced silencing complex (RISC), the protein complex responsible for RNA interference (RNAi) gene silencing. Argonaute proteins bind different classes of small non-coding RNAs, including microRNAs (miRNAs), small obstruct RNAs (siRNAs), and Piwi-interacting RNAs (piRNAs). Small RNAs guide Argonaute proteins to their precise targets through sequence complementarity, which typically leads to silencing of the target.
Original Link: https://www.biotechdaily.com/genomics-proteomics/articles/294775030/deleting-liver-protein-improves-glucose-metabolism.html

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