Category: Research

Welcome to part three and the final part of our SENS Undoing Aging 2018 interview; we have a few more scientific questions today for Aubrey and his team as well as questions about future developments and taking new therapies to market. Dr. de Grey, has your position on the relevance of telomere attrition changed since…

Welcome to part two of our three-part Undoing Aging 2018 interview of Dr. Aubrey de Grey and his team at SENS Research Foundation. Today, we have some of the scientific questions that the community had about SENS; there are some very detailed responses, and we hope you enjoy them. Regarding the use of senolytics, are…

As the Undoing Aging 2018 Conference approaches, excitement and interest about the event are growing among both aging scientists and rejuvenation enthusiasts alike. If you’re a regular on our blog, neither Undoing Aging 2018’s main organizer, SENS Research Foundation, nor the main sponsor, Michael Greve’s Forever Healthy Foundation, need much of an introduction, but for…

Researchers have identified a protein that is different between healthy and cancerous cells, offering a potential target for therapeutic interventions. Abstract Sorting nexins anchor trafficking machines to membranes by binding phospholipids. The paradigm of the superfamily is sorting nexin 3 (SNX3), which localizes to early endosomes by recognizing phosphatidylinositol 3-phosphate (PI3P) to initiate retromer-mediated segregation…

If you need yet another reason to exercise as part of your health and longevity strategy, then check out this study, which suggests that aging of the immune system can be slowed by exercise. The problem with our modern lives is that we are, in general, much more sedentary than our ancient ancestors, who hunted…

Researchers at Harvard have described a new cancer vaccine approach that uses an injectable biomaterial scaffold to deliver a payload of tumor-specific peptides that stimulate the immune system to respond rapidly to cancer cells. Abstract Existing strategies to enhance peptide immunogenicity for cancer vaccination generally require direct peptide alteration, which, beyond practical issues, may impact…

Some cancer cells express some of the same genes that senescent cells do, so it makes sense that drugs that destroy senescent cells may also destroy cancer cells. This was what the researchers in this new study set out to test. Abstract p16Ink4a is a potent cell cycle inhibitor engaged to support cell cycle arrest…

The human heart is an organ whose cells rarely divide, making tissue repair and regeneration a huge problem following a heart attack. Many animals, such as zebrafish and salamanders, are different; they can regenerate damaged hearts easily. As humans, we also once had the same regenerative capacity during our early development, but after we were…

A potential new biomarker of aging has been discovered by researchers. This substance, found in urine, indicates oxidative damage that could be used to determine how much someone has aged biologically. Why do we need biomarkers of ageing? It is important for us to develop accurate and reliable biomarkers of aging, as these can show…

Researchers at the School of Molecular Sciences at Arizona State University have discovered a potential way to supercharge our stem cells and reverse some aspects of cellular aging. The Hayflick limit Normal cells cannot divide indefinitely; they have a built-in replicative limit, which is often called the Hayflick limit after its discoverer, Leonard Hayflick. This…