Current evidence suggests that multiple sclerosis (MS) results from
an autoimmune response mediated by T lymphocytes, which would be activated
in the peripheral blood and migrate into the central nervous system.

NFkappaB
and AP-1 are two main transcription factors involved in T-cell activation.

To investigate possible alterations in the activity of these factors in
MS individuals, we have assayed NFkappaB and AP-1 DNA binding activity
in peripheral blood mononuclear cells (PBMC).

No significant
differences were found between the two groups, indicating no evidence of
abnormalities associated with MS in NFkappaB or AP-1 binding activities
in PBMC, both basally and after PMA+anti-CD3 antibody induction.