Prototype 2 is an open-world action game published by Activision and developed by Radical Entertainment. Prototype 2 is a direct sequel to Prototype. The events of Prototype 2 takes place in New York City, now known as New York Zero, following Sgt. James Heller on his quest to destroy Alex Mercer, after having lost everything and everyone he loved to the Blacklight virus.

14 months after the Blacklight being Alex Mercer saved the infected New York on his quest for redemption, Sgt. James Heller returns to the city, once his home, following his dismissal from a war in the Middle East. He discovers that his wife and daughter have been killed, sending him into a downward spiral of grief and rage. He heads out on a suicide mission into the heart of the Red Zone with the intention of dying in action and taking as many abominations as he can with him.