Abstract

Background: A number of biomarkers have been found that might help to predict the risk of acute coronary syndrome (ACS)
in adults.
Aim: To analyse the association between immunoglobulins concentration and other inflammatory markers such as C-reactive
protein (CRP) and fibrinogen that show correlation with the risk of ACS.
Methods: The study population consists of 52 consecutive patients with ST segment elevation myocardial infarction (STEMI)
or unstable angina/non-STEMI. Concentrations of total protein, albumin, alpha-1 globulin, beta globulin, gamma protein,
immunoglobulin in class A (IgA), G (IgG), M (IgM) and E (IgE), creatinine kinase (CK), creatinine kinase MB (CK-MB), CRP and
fibrinogen were quantified.
Results: In the ACS patients, there was a significant increase in gamma globulin, CRP and fibrinogen. IgG was elevated only
in the STEMI group and correlated with fibrinogen (R = 0.48, p < 0.01).
Conclusions: 1. IgG appears to be the only immunoglobulin associated with ACS in the STEMI group. 2. Fibrinogen reveals
features of a reactive biomarker of ACS. 3. CRP appears to be closely related to the causative process in coronary artery
disease patients.

Abstract

Background: A number of biomarkers have been found that might help to predict the risk of acute coronary syndrome (ACS)
in adults.
Aim: To analyse the association between immunoglobulins concentration and other inflammatory markers such as C-reactive
protein (CRP) and fibrinogen that show correlation with the risk of ACS.
Methods: The study population consists of 52 consecutive patients with ST segment elevation myocardial infarction (STEMI)
or unstable angina/non-STEMI. Concentrations of total protein, albumin, alpha-1 globulin, beta globulin, gamma protein,
immunoglobulin in class A (IgA), G (IgG), M (IgM) and E (IgE), creatinine kinase (CK), creatinine kinase MB (CK-MB), CRP and
fibrinogen were quantified.
Results: In the ACS patients, there was a significant increase in gamma globulin, CRP and fibrinogen. IgG was elevated only
in the STEMI group and correlated with fibrinogen (R = 0.48, p < 0.01).
Conclusions: 1. IgG appears to be the only immunoglobulin associated with ACS in the STEMI group. 2. Fibrinogen reveals
features of a reactive biomarker of ACS. 3. CRP appears to be closely related to the causative process in coronary artery
disease patients.

Authors

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