Benzyltrimethylammonium chloride

ベンジルトリメチルアンモニウムクロリド

[CAS No. 56-93-9]

塩化ベンジルトリメチルアンモニウム

Molecular formula: C10H16ClN Molecular weight: 185.70

ABSTRACT

With regard to repeat dose toxicity, one female given 120 mg/kg died during the 4th week of the dosing period. Increased salivation was observed in males given 60 mg/kg or more and females of the 120 mg/kg group, and lacrimation, piloerection and or soiled fur were noted in males and or females given 120 mg/kg. Suppression of body weight gain, decrease in food consumption and elevated HGB, MCV and MCH levels were noted in males of the 120 mg/kg group. No gross and microscopic findings attributable to the administration of the chemical were evident, except for hepatocellular swelling and eosinophilic bodies in the one female which died. NOELs for repeat dose toxicity are considered to be 30 mg/kg/day for males and 60 mg/kg/day for females.

Benzyltrimethylammonium chloride was not mutagenic to Salmonella typhimurium, TA100, TA1535, TA98, TA1537 and Escherichia coli WP2 uvrA, with or without an exogeneous metabolic activation system.

One female given 120 mg/kg died during the 4 th week of the dosing period. Increased salivation was observed in males given 60 mg/kg or more and females of the 120 mg/kg group, increased lacrimation and soiled fur were noted in 120 mg/kg males and females, and increased piloerection was observed in females of the 120 mg/kg group. Suppression of body weight gain and decreased food consumption were noted in males given 120 mg/kg. Hematological examination revealed increase of HGB, MCV and MCH levels in males of the 120 mg/kg group. Histopathological examination of the dead animal revealed hepatocellular swelling and eosinophilic bodies. NOELs for repeat dose toxicity are considered to be 30 mg/kg/day for males and 60 mg/kg/day for females.