PROJECT 10:

Host:

Huntington's disease (HD) is a neurodegenerative genetic disorder that affects muscle coordination and leads to cognitive decline and psychiatric problems. It is caused by a CAG repeat expansion in Exon 1 of the huntingtin (HTT) gene which translates to a polyglutamine tract close to the N-terminus of the huntingtin protein (HTT). Symptoms progress over a period of 15-20 years until death and disease modifying treatments do not currently exist.

The main focus of our work uses mouse models of HD to

Better understand the molecular pathogenesis of HD

Validate therapeutic targets

Participate in the preclinical development of therapeutic interventions