B6;129 Background

Constitutive knockout of the three prime repair exonuclease I gene (Trex1)

Model of Aicardi-Goutieres syndrome

Displays inflammatory myocarditis and autoimmune disease

Homozygous knockouts have a reduced lifespan

Origin:

The Trex1 Knockout Mouse was developed in the laboratories of Tomas Lindahl at the Clare Hall Laboratories, Imperial Cancer Research Fund (now Cancer Research UK). The model was created using a targeting vector that replaced amino acids 103-207 of the Trex1 open reading frame with a neo cassette in GK129 ES cells derived from the 129P2 strain. Targeted ES cells were injected into C57BL/6J blastocysts. Taconic received frozen embryos from CRT in 2013.