Chemo and I were talking about this once and here's the conclusion that I came to (thanks to Chemo's help):

The shorter the ester, the less soluable in the oil depo it is. So, when the oil depo begins to dissipate after a day or two, the steroid begins to precipitate out of solution and Chemo said it begins to crystallize or something like that, and that those crystals are the cause of the pain.

There you have my conclusion, anybody else?

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LG.

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Originally posted by Lifeguard Chemo and I were talking about this once and here's the conclusion that I came to (thanks to Chemo's help):

The shorter the ester, the less soluable in the oil depo it is. So, when the oil depo begins to dissipate after a day or two, the steroid begins to precipitate out of solution and Chemo said it begins to crystallize or something like that, and that those crystals are the cause of the pain.

There you have my conclusion, anybody else?&nbsp;&nbsp;

LG. &nbsp;&nbsp;

That was some time ago bro...I'm surprised you remember that!

LG is right on the mark when he relates short chain ester (acetates, props, etc.) and pain as a function of solubility.&nbsp; All AAS compounds are oil soluble to a degree but esterfied molecules are GREATLY MORE soluble than their base derivatives.&nbsp; Yet, even among the esterfied products there are different degrees of solubility.

Most recipes call for BA as a solvent (typically 1-10%) but this&nbsp;is also water soluble.&nbsp; After inject, the BA is rapidly absorbed and leaves the short chain ester to fend for itself in an oil only environement.&nbsp; Some of the AAS will crystallize due to a lower solubility and pain will ensue.

A common method of reducing or eliminating this is by adding up to 20% BB (benzyl benzoate) as a CO-SOLVENT.&nbsp; Commercial preps of AAS injects all include this at that concentration but even 10% has been noted to have great pain reducing properties for short chain esters.&nbsp; It works by staying at the depot long after the BA has been absorbed thus keeping more AAS in solution = less ctystallization, less pain.