Biomedical Research

Vascular endothelial growth factor (VEGF) can induce neovascularization. We recent found that the number of osteoclasts was enhanced of VEGF with the application of mechanical force for experimental tooth movement. In this study, the VEGF was detected in osteoblasts and periodontal tissues on the tension and pressure side of the alveolar bone. Moreover, the neovascularization was significantly increased in the tooth movement by magnet groups compared with the control. These results suggest that VEGF, highly expressed by mechanical stimuli, enhances the number of neovascularizations as the paracrine factor is accelerated by magnetic force.