I have been having this problem for over a year, and I am using the current non-beta release of the Catalyst software downloaded today.

When I use the Catalyst Control Center to change the color depth, or which monitors are active or primary, the change takes effect after I click "Apply", but about 30 seconds later it reverts to the previous configuration. Based on experience, I expect that there should be a dialog that pops up to ask "keep these settings?", but no such dialog appears.

When I change the same settings using the Windows 7 "Screeen Resolution" window, or through the display Advanced Settings window, I get a "keep these settings?" dialog and when I answer yes the new settings persist.

Why isn't the AMD Catalyst Control Center displaying the "Keep these settings?" dialog?

Ive also noticed this. I once accedently changed to a non suported resolution and had to drag out another monitor to fix it. (good thing i had one) Oddly enough, sometimes when I switch between native and other supported resolutions it will revert back... lol wtf

I dont remember why safe mode or boot options wouldnt allow me to fix. I dont get a "keep these settings" and it dont go back to a prior resolution.

I did notice that some EDID check or uncheck would allow the changes to stick..I dunno, I dont really worry about it. I have never had a "keep these settings" using ccc on this system