Enhance potency of autologous CAR-T cells within the tumor microenvironment

Production of ‘universal’ allogeneic CAR-T cells

Devon Shedlock, Vice President, Preclinical Development, Poseida

11.40 Cibus’ Trait Machine is Accelerating Plan Breeding Using the Rapid Trait Development System (RTDS™) to Benefit Consumers, Farmers and Processors

Over thousands of years, breeders have relied on random variation for crop improvement

Cibus has developed a process called the Rapid Trait Development System (RTDS) that combines advanced cell culture and a range of modern mutagenesis tools to accelerate plant breeding by precisely specifying beneficial typographical changes in crop genomes much like a word processor on your computer

What used to be a random process taking many years can now be accomplished in months with outcomes indistinguishable from those that can occur in nature

Complex pools of lentiviral-based sgRNA libraries provide one of the most effective tools to uncover the functional genetic elements that regulate disease pathologies, drug efficacy, and other biological responses.

13.50 Future Safety and Efficacy: Exploring the Alignment of CRISPR and the Future of Therapeutic Development to the Future of Clinical Trial Design

Discuss how drug development and regulatory processes need to continue to embrace data science technology to enhance clinical trial efficiency for therapeutics using CRISPR as well as other innovations

Explore the history of the Virtual Subject model for Clinical Trial development and execution

Address opportunities, considerations, and best practices to drive toward the frontier of executing trials with Virtual Subjects

Dan Tierno, Strategic Implementation Manager, Bayer

14.20 Taking CRISPR to the Clinic

Efficient editing at clinical scale and in long-term repopulating HSCs

Editing results in relevant pharmocodynamic effect

Careful choice of gRNAs results in high specificity and no detectible off-target events

Progressing to the clinic after scale-up and regulatory/toxicology studies

12.50Networking Lunch

15.20Afternoon Refreshments

15.50 How do you know? Measurements and Standards to Support Confidence in Genome Editing

Synopsis

NIST is the measurement institute of the U.S., supplying unbiased expertise in measurements and standards to support growth in all sectors of economy and commerce including healthcare and the bio-economy

NIST has been working with experts in the genome editing field to identify precompetitive needs for establishing confidence in assessing the results of genome editing protocols

NIST is launching a NIST led Genome Editing Consortium as a public private partnership to bring together academia, non-profit, industry and other government to generate best practices, high quality data, a standard lexicon and data/metadata norms for the genome editing field

18.00 Evening Drinks Reception & Table Top Discussions

Synopsis

Drive your own learning and brain storm ideas. The CRISPR speaker faculty is second to none but there is just as much knowledge in the audience as there is onstage. We want to make sure you can tap into this wealth of experience and expertise. Discover multiple perspectives on the key issues affecting the CRISPR field by joining roundtable discussions, specifically designed so you can learn from your fellow gene-editing peers.

Our contact details

Venue Details

TBC

About Us

Hanson Wade's goal is to accelerate progress within organisations and across industries. Our primary method for achieving this is by creating exclusive business conferences that gather together the world's smartest thinkers and doers.