Fisher children - Preston, WV and Fayette PA

Recently a fellow genealogist sent me some 1850 census information on a number of Fisher children that were split up into these two counties. These children were my great great grandfathers brothers and sisters. I also learned that the vital records for Preston County, WV were destroyed in a fire in 1869. My grandmother told me once that the father of these children was John Fisher. Hopefully someone out there will know these children and why they had to be split up because it seems they were split among different family members.