Six prototype one-way RC slabs with openings were strengthened with externally bonded carbon fiber-reinforced polymer (CFRP) systems and subjected to concentrated line loads. The results were compared to those of a solid slab without opening and a slab with an unstrengthened opening. The CFRP system proved to be effective in enhancing the load-carrying capacity and stiffness of RC slabs with an opening, provided that premature failure due to CFRP debonding is excluded. An analytical model based on the modified yield line method is presented, in which four failure modes comprising one orthogonal and three nonorthogonal yield line patterns were considered. The analytical model predicts the load carrying capacity of the strengthened slabs very well. The opening width has a more prominent effect on the load-carrying capacity than does the opening length.