Miami quickly fell behind 10-0 and trailed much of the game, but improved to 3-0 for the first time since 2002. The Falcons fell to 1-2.

Tannehill led the comeback and finished 24 for 35 for 236 yards and two scores. He overcame five sacks and two turnovers.

Titans 20, Chargers 17: Jake Locker helped Tennessee end a skid against the San Diego that spanned two states and two decades.

Locker threw a 34-yard touchdown pass to rookie Justin Hunter with 15 seconds left and the Titans rallied to beat the Chargers.

It was their first win over the Chargers for the franchise since 1992 when the team was in Houston and Titans coach Mike Munchak still was playing for the then-Oilers.

The Titans (2-1) had lost nine straight to San Diego (1-2). Locker ended the slide by completing seven passes to six receivers for 94 yards on the game-winning drive. He finished with 299 yards passing and ran for 68 yards.

Saints 31, Cardinals 7: Drew Brees passed for three scores and scrambled for New Orleans' first touchdown rushing of the season in a victory over Arizona.

The Saints quarterback was 29 of 46 for 342 yards, with two TD strikes to tight end Jimmy Graham and the other to Robert Meachem.

Brees was intercepted once by New Orleans native and former LSU star Tyrann Mathieu. That play ended a scoring threat, but only delayed the inevitable on a day when Arizona's short-handed defense was little match for the prolific passing attack of the Saints (3-0).

Patriots 23, Buccaneers 3: Tom Brady threw two touchdown passes to Kenbrell Thompkins to lead New England to a one-sided win over Tampa Bay.

Thompkins, an undrafted free agent, scored on plays of 16 and 5 yards in the first half. Aaron Dobson, a second-round draft pick, finished with seven catches for 52 yards. In their first two games, the rookies combined for just nine receptions.

Cowboys 31, Rams 7: DeMarco Murray ran for 175 yards and a touchdown two years after torching St. Louis with a franchise record as a rookie, and Tony Romo threw for three scores in Dallas' rout.

Murray had his first 100-yard game in more than a year.

The Cowboys (2-1) sacked Sam Bradford four times in the first half and had six overall after St. Louis (1-2) hadn't allowed a sack in four games, dating to last season.

Ravens 30, Texans 9: Daryl Smith had a 37-yard interception return for a TD, Tandon Doss took a punt 82 yards for another score, and Baltimore smothered Houston's high-powered offense.

The Ravens (2-1) won despite playing without Ray Rice for the first time since 2008. The three-time Pro Bowl running back was replaced by Bernard Pierce, who ran for 65 yards and a touchdown.

Lions 27, Redskins 20: Matthew Stafford completed 25 of 42 passes for 385 yards with two touchdowns and one interception, and Calvin Johnson and Nate Burleson both had 100 yards receiving for Detroit, which beat Washington on the road for the first time since 1939.

The Lions (2-1) ended a 21-game streak against the Redskins, the second-longest in NFL history. Detroit's last win away from home in the series came in 1935 against the Boston Redskins, two years before the move to Washington (0-3).

Browns 31, Vikings 27: Jordan Cameron caught three touchdown passes, including the go-ahead grab in the back of the end zone with 51 seconds left, and Cleveland kept Minnesota winless.

Third-stringer Brian Hoyer threw for three scores for the Browns (1-2), the latest team to torch Minnesota's depleted secondary. He overcame three interceptions to throw for 321 yards, going 30 for 54. Josh Gordon had 10 catches for 146 yards and a touchdown in his season debut, and Cameron had six receptions for 66 yards.

Bengals 34, Packers 30: Terence Newman returned a fumble 58 yards for a touchdown with 3:47 left, rallying Cincinnati past Green Bay in a game of wild momentum swings set up by nonstop turnovers.

Each team gave it away four times. Each team returned a fumble for a touchdown - M.D. Jennings ran one back for Green Bay (1-2). The Bengals blew a 14-point lead, and the Packers let a 16-point lead get away in the second half.

The Bengals (2-1) finished it off when Michael Johnson batted down Aaron Rodgers' fourth-down pass at the Cincinnati 20-yard line with 1:21 left, ending a subpar showing for the quarterback.

Seahawks 45, Jaguars 17: Russell Wilson matched his career high with four touchdown passes - two each to Sidney Rice and Zach Miller - and Seattle dominated as expected.

Seattle improved to 3-0 for the first time since 2006, beginning a stretch of four straight games against the AFC South. And none will likely be easier than overwhelming the Jaguars.

Jets 27, Bills 20: Geno Smith threw two touchdown passes, including a go-ahead 69-yarder to Santonio Holmes in the fourth quarter and New York overcame a team-record 20 penalties to hang on for victory.

Smith slightly outplayed EJ Manuel in a matchup of the first two quarterbacks selected in the NFL draft in April. But this one was tough to watch at times with the barrage of penalties. The Jets (2-1) rolled up 168 yards in penalty yardage, and nearly gave it away against the Bills (1-2).