Is your DNA _cutting_ all right? If it cuts, and gives a good
smear on the gel, you don't need to clean it up. It is perhaps more
likely that you have a transfer of hybridization problem.
(Cleaning up genomic DNA with a column is not a very good idea -
it breaks!).
*******************************************************************
Michael Morris PhD
Division of Medical Genetics tel (Switzerland) (22) 702.56.94
CMU, University of Geneva fax (Switzerland) (22) 702.57.06
Geneva, Switzerland email mike at medsun.unige.ch