In his first book, Scepticism and the Foundation of Epistemology, Floridi was already looking for a concept of subject-independent knowledge close to what he now identifies as semantic information.[14] During his postdoctoral studies, as a Junior Research Fellow of Wolfson College, Oxford University, he began to embrace a more Neo-Kantian philosophy, which led him to spend one academic year in Marburg, where he focused on Ernst Cassirer's version of Neo-Kantianism.[15] He began working exclusively on what is now known as the philosophy of information during his years as Research Fellow, still at Wolfson College.[9]

According to Floridi, it is necessary to develop a constructionist philosophy, where design, modelling and implementation replace analysis and dissection. Shifting from one set of tasks to the other, philosophy could then stop retreating into the increasingly small corner of its self-sustaining investigations and hence reacquire a wider view about what really matters. Slowly, Floridi has come to characterise his constructionist philosophy as an innovative field, now known as the philosophy of information, the new area of research that has emerged from the computational/informational turn.

For example, in the Preface of Philosophy and Computing, published in 1999, he wrote that the book was meant for philosophy students who need IT literacy to use computers efficiently or indispensable background knowledge for the critical understanding of our digital age. The latter provides a basis for the would-be branch of philosophy, the philosophy of information. PI, or PCI (Philosophy of Computing and Information), became his major research interest.

Floridi's perspective is that there is a need for a broader concept of information, which includes computation, but not only computation. This new framework provides a theoretical framework within which to make sense of various lines of research that have emerged since the fifties. The second advantage is PI’s perspective on the development of philosophy through time. In his view, PI gives us a much wider and more profound perspective on what philosophy might have actually been doing throughout the centuries.

Winner of the International Society for Ethics and Information Technology - INSEIT's Weizenbaum Award for "significant contribution to the field of information and computer ethics, through his or her research, service, and vision.”[30]

Minds and Machines, Springer, is preparing a special issue dedicated to his work, entitled Philosophy in the Age of Information: A Symposium on Luciano Floridi's The Philosophy of Information (Oxford, 2011)"[31]

^According to The St Cross College Annual Record, "One of the achievements of which is most proud is having his name engraved on the Oxford Squash Plate and Cup trophies, as captain of the Wolfson teams who won cuppers in 1998-2002."