This work was financially supported by Research Grant Council 201508 and HKBU FRGs. We thank the participants and the submitters for depositing samples at the N1NDS Neurogenetics repository. The samples for this study are derived from the NINDS Neurogenetics repository at Coriell Cell Repositories. Access to the samples and to these data are available from the website: http://ccr.coriell.org/Sections/BrowseCatalog/DiseaseDetail.aspx? PgId=403&omim=PAR4000082coll=.