Grumpy Cat, the adorably grouchy-looking meme machine kitty, has passed away. The family of the dearly departed cat said she suffered complications from a urinary tract infection. She died on Tuesday at the age of seven.

Her world-famous expression was the result of a birth defect, and Grumpy’s owners parlayed her popularity into a multimillion-dollar empire, with merchandise, books and a Lifetime movie. As you might expect, tributes flooded in following the news of her passing.

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