Dr. Nigwekar and his team studied 33 participants from three phase II studies to test the potency of ALLN-177. The patients observed each had enteric hyperoxaluria because of conditions or procedures such as gastric bypass surgery, Crohn's disease or short bowel syndrome.

Analysis of patient data revealed that as high as 80% of patients with enteric hyperoxaluria also had kidney stones. Many had stones in both kidneys, some had multiple stones in one kidney, and some had stones large enough to require clinical intervention.

Based on the findings above, Dr. Nigwekar emphasizes that nephrologists must be aware of enteric hyperoxaluria as a complication in patients who have undergone procedures such as gastric bypass surgery, as well as those who have experienced other gastrointestinal disorders such as short bowel syndrome. This awareness is crucial for alleviating patients' kidney stone burden.

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