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Los Angeles firefighters on Saturday evening extinguished a fire at a West Hills home that later became the scene of a narcotics investigation, officials said.

Los Angeles firefighters are seen at a burned-out house in West Hills on Saturday, May 23, 2015. (Credit: RMG News)

The two-story single-family residence in the 6500 block of North Ellenview Avenue (map) was initially well-involved in flames, and its roof completely collapsed, according to the Los Angeles Fire Department.

Neighbor Tracy Haynes said he heard two explosions before he saw the fire.

"I was sitting in my house and then I heard a boom, and then probably a few minutes after that I heard another boom," he said. "They were almost identical."

Eighty firefighters conducted a "defensive operation," then fully contained the blaze after just over an hour. Charged electrical lines were possibly down inside the structure, the LAFD said on Twitter.

Two burn patients were transported to West Hills Hospital from a different address, located several blocks from the fire, the Fire Department said. Their conditions were not immediately known.

No firefighters were injured.

The structural integrity of the home was in question after the incident, fire officials said.

Following an inspection by the Department of Building and Safety, Los Angeles Police Department investigators planned to enter the burned-out house and investigate it as the site of a possible clandestine drug laboratory, LAPD officials said.