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Interstate 90 (I-90) / WA-17 Going west on I-90 from Spokane, Ephrata is accessed from Exit 179 (S Pioneer WA-17). Go another 0.8mi along Pioneer Way going towards Moses Lake (City Center) to the WA-17 exit towards "Ephrata/Soap Lake". Follow signs for the next 17mi/27km northwest to Ephrata the county seat or 37mi/43km (:37min) south to Othello in the other directions. Located 104mi/165km (1hr38min) west of Spokane and 178mi/285km (2hr44min) east of Seattle.

Interstate 90 (I-90) / WA-283 Going east on I-90, from Seattle, Ephrata is accessed from Exit #151 (Ephrata/Soap Lake). Go NE along WA-283 for the next 20mi/32km to get into Ephrata. WA-283 goes through town as Basin St.