mitotane

mitotane

an oral chemotherapeutic agent that causes selective necrosis and atrophy of the adrenocortical zona fasciculata and zona reticularis. Used in the treatment of inoperable adrenal cortical carcinoma in humans and in canine Cushing's syndrome. Called also o,p-DDD.

For treatment, mitotane remains the major chemotherapeutic option for the management of adrenal carcinoma because it is a relatively specific adrenocortical cytotoxin although its capacity to prolong clinical survival is uncertain.

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