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{\*\bkmkstart filing_1}{\*\bkmkend filing_1}{\*\bkmkstart doc_1_1}{\*\bkmkend doc_1_1}\par\pard\plain\cf1\f51\fs20\qr \~\par\pard\plain\cf1\f51\fs20\qr Filed by Idera Pharmaceuticals,\~Inc. pursuant to Rule\~425\par\pard\plain\cf1\f51\fs20\qr Under the Securities Act of 1933\par\pard\plain\cf1\f51\fs20\qr And Deemed Filed Pursuant to Rule\~14a-12\par\pard\plain\cf1\f51\fs20\qr Under the Securities Exchange Act of 1934\par\pard\plain\cf1\f51\fs20\qr Subject Company: BioCryst Pharmaceuticals,\~Inc.\par\pard\plain\cf1\f51\fs20\qr Commission File No.\~of Subject Company: 000-23186\par\pard\plain\cf1\f51\fs20\qr \~\par\pard\plain\cf1\f51\fs20\qr \~
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\pard\plain\intbl\f0\fs16\ql \~\cell{
{\trowd\cellx5400\cellx10800\trrh1451\row}}}\pard\plain\cf1\f51\fs20\b\qc \~\par\pard\plain\cf1\f51\fs20\b\qc BioCryst Pharmaceuticals and Idera Pharmaceuticals
\par\pard\plain\fs16\pard\plain\cf1\f51\fs20\b\qc Reschedule Meetings to Vote on Proposed Merger\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\i\qc BioCryst and Idera Special Meetings to Be Held on July\~10, 2018\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\i\qc New Clinical Data on Idera\u8217?s IMO-2125 Program Will Be Available Prior to Vote\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\ql RESEARCH TRIANGLE PARK, N.C. and EXTON, P.A.\plain\cf1\f51\fs20\ql \u8212?\plain\cf1\f51\fs20\b\ql April\~10, 2018\plain\cf1\f51\fs20\ql \u8212? BioCryst Pharmaceuticals,\~Inc.\plain\cf1\f51\fs20\ql (NASDAQ:BCRX) (\u8220?BioCryst\u8221?) and Idera Pharmaceuticals,\~Inc. (NASDAQ:IDRA) (\u8220?Idera\u8221?) today\plain\cf1\f51\fs20\ql jointly announced that they have each rescheduled their respective Special Meetings of Stockholders (each, a \u8220?Special\plain\cf1\f51\fs20\ql Meeting\u8221?) to vote on the proposed merger of BioCryst and Idera to July\~10, 2018 at 10:00 AM ET.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\li550\fi-264\cf1\f53\fs20\ql ·\plain\li550\cf1\f51\fs6\ql \~\~\~\~\~\~\~\~\~\~\~\~\~\~\~\~\~\plain\li550\cf1\f51\fs20\ql BioCryst will hold its Special Meeting at its corporate offices in Durham, North Carolina. BioCryst stockholders of\plain\li550\cf1\f51\fs20\ql record as of May\~28, 2018 will be entitled to vote at the BioCryst Special Meeting.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\li550\fi-264\cf1\f53\fs20\ql ·\plain\li550\cf1\f51\fs6\ql \~\~\~\~\~\~\~\~\~\~\~\~\~\~\~\~\~\plain\li550\cf1\f51\fs20\ql Idera will hold its Special Meeting at its corporate offices in Exton, Pennsylvania. Idera stockholders of record as of\plain\li550\cf1\f51\fs20\ql May\~28, 2018 will be entitled to vote at the Idera Special Meeting.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\ql BioCryst and Idera are each rescheduling their respective Special Meetings, following investor feedback, to provide stockholders\plain\cf1\f51\fs20\ql adequate time to consider new clinical data from Idera regarding its IMO-2125 program, which will be presented at the\plain\cf1\f51\fs20\ql American Society of Clinical Oncology (\u8220?ASCO\u8221?) meeting being held June\~1-5, 2018 in Chicago.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\ql The BioCryst Board of Directors unanimously recommends that BioCryst stockholders vote \u8220?FOR\u8221? the proposed\plain\cf1\f51\fs20\ql merger at the BioCryst Special Meeting.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\ql The Idera Board of Directors unanimously recommends that Idera stockholders vote \u8220?FOR\u8221? the proposed merger at\plain\cf1\f51\fs20\ql the Idera Special Meeting.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\ql BioCryst\u8217?s stockholders as of the May\~28, 2018 record date who have previously voted, and do not wish to change their\plain\cf1\f51\fs20\ql vote, will not need to vote again at the rescheduled July\~10, 2018 BioCryst Special Meeting.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\ql Idera\u8217?s stockholders as of the May\~28, 2018 record date who have previously voted, and do not wish to change their vote,\plain\cf1\f51\fs20\ql will not need to vote again at the rescheduled July\~10, 2018 Idera Special Meeting.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\ql BioCryst and Idera will file amended proxy materials with the U.S. Securities and Exchange Commission (\u8220?SEC\u8221?)\plain\cf1\f51\fs20\ql related to the rescheduled Special Meetings and will mail the updated materials to stockholders in due course. The amended\plain\cf1\f51\fs20\ql definitive proxy statement will also be made available at www.iderapharma.com and www.biocryst.com, respectively (in the\plain\cf1\f51\fs20\ql \u8220?Investors\u8221? section) and on the SEC website at www.sec.gov.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\ql About BioCryst\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\ql BioCryst designs, optimizes and develops novel small-molecule medicines that address both common and rare conditions.\plain\cf1\f51\fs20\ql BioCryst has several ongoing development programs including BCX7353, an oral treatment for hereditary angioedema,\plain\cf1\f51\fs20\ql galidesivir, a potential treatment for filoviruses, and a preclinical program to develop oral Alk-2 inhibitors for the treatment of\plain\cf1\f51\fs20\ql fibrodysplasia ossificans progressive (FOP).\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par
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\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\ql RAPIVAB\u174? (peramivir injection), a viral neuraminidase inhibitor for the treatment of influenza, is BioCryst\u8217?s first\plain\cf1\f51\fs20\ql approved product and has received regulatory approval in the U.S., Canada, Japan, Taiwan and Korea. Post-marketing\plain\cf1\f51\fs20\ql commitments for RAPIVAB are ongoing, as well as activities to support regulatory approvals in other territories. For more\plain\cf1\f51\fs20\ql information, please visit the company\u8217?s website at www.biocryst.com.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\ql About Idera\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\ql Harnessing the approach of the earliest researchers in immunotherapy and the company\u8217?s vast experience in developing\plain\cf1\f51\fs20\ql proprietary immunology platforms,\~Idera\u8217?s lead development program is focused on priming the immune system to play a\plain\cf1\f51\fs20\ql more powerful role in fighting cancer, ultimately increasing the number of people who can benefit from immunotherapy. Idera\plain\cf1\f51\fs20\ql continues to invest in research and development, and is committed to working with investigators and partners who share the\plain\cf1\f51\fs20\ql common goal of addressing the unmet needs of patients suffering from rare, life-threatening diseases. To learn more about Idera,\plain\cf1\f51\fs20\ql visit www.iderapharma.com.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\ql Additional Information and Where to Find It\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\ql In connection with the proposed mergers, Nautilus Holdco,\~Inc. (\u8220?Holdco\u8221?) has filed with the U.S. Securities and\plain\cf1\f51\fs20\ql Exchange Commission (the \u8220?SEC\u8221?), and the SEC has declared effective on March\~29, 2018, a Registration\plain\cf1\f51\fs20\ql Statement on Form\~S-4 (as may be amended from time to time, the \u8220?Registration Statement\u8221?) that includes the joint\plain\cf1\f51\fs20\ql proxy statement of BioCryst Pharmaceuticals,\~Inc. (\u8220?BioCryst\u8221?) and Idera Pharmaceuticals,\~Inc.\plain\cf1\f51\fs20\ql (\u8220?Idera\u8221?) and that also constitutes a prospectus of Holdco. BioCryst,\~Idera and Holdco may also file other\plain\cf1\f51\fs20\ql documents with the SEC regarding the proposed transaction. This document is not a substitute for the definitive joint proxy\plain\cf1\f51\fs20\ql statement/prospectus or Registration Statement or any other document that may be filed by each of BioCryst and Idera with the\plain\cf1\f51\fs20\ql SEC. BEFORE MAKING ANY VOTING DECISION,\~IDERA\u8217?S AND BIOCRYST\u8217?S RESPECTIVE\plain\cf1\f51\fs20\ql STOCKHOLDERS ARE URGED TO READ THE JOINT PROXY STATEMENT/PROSPECTUS IN ITS ENTIRETY AND\plain\cf1\f51\fs20\ql ANY OTHER DOCUMENTS FILED BY EACH OF IDERA AND BIOCRYST WITH THE SEC IN CONNECTION WITH\plain\cf1\f51\fs20\ql THE PROPOSED TRANSACTION OR INCORPORATED BY REFERENCE THEREIN BECAUSE THEY CONTAIN\plain\cf1\f51\fs20\ql IMPORTANT INFORMATION ABOUT THE PROPOSED TRANSACTION AND THE PARTIES TO THE PROPOSED\plain\cf1\f51\fs20\ql TRANSACTION. Investors and stockholders may obtain free copies of these materials and other documents filed with the SEC\plain\cf1\f51\fs20\ql (when available) by BioCryst,\~Idera and Holdco through the website maintained by the SEC at www.sec.gov. Idera and BioCryst\plain\cf1\f51\fs20\ql make available free of charge at www.iderapharma.com and www.biocryst.com, respectively (in the \u8220?Investors\u8221?\plain\cf1\f51\fs20\ql section), copies of materials they file with, or furnish to, the SEC.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\ql Participants in the Solicitation\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\ql This document does not constitute a solicitation of proxy, an offer to purchase or a solicitation of an offer to sell any securities.\plain\cf1\f51\fs20\ql Idera, BioCryst and their respective directors, executive officers and certain employees and other persons may be deemed to be\plain\cf1\f51\fs20\ql participants in the solicitation of proxies from the stockholders of Idera and BioCryst in connection with the proposed mergers.\plain\cf1\f51\fs20\ql Security holders may obtain information regarding the names, affiliations and interests of Idera\u8217?s directors and officers in\plain\cf1\f51\fs20\ql Idera\u8217?s Annual Report on Form\~10-K for the fiscal year ended December\~31, 2017, which was filed with the SEC on\plain\cf1\f51\fs20\ql March\~7, 2018 and its definitive proxy statement for the 2017 annual meeting of stockholders, which was filed with the SEC on\plain\cf1\f51\fs20\ql April\~28, 2017. Security holders may obtain information regarding the names, affiliations and interests of BioCryst\u8217?s\plain\cf1\f51\fs20\ql directors and officers in BioCryst\u8217?s Annual Report on Form\~10-K for the fiscal year ended December\~31, 2017, and any\plain\cf1\f51\fs20\ql amendments thereto, which was filed with the SEC on March\~12, 2018 and its definitive proxy statement for the 2017 annual\plain\cf1\f51\fs20\ql meeting of stockholders, which was filed with the SEC on April\~12, 2017. Additional information about the interests of\plain\cf1\f51\fs20\ql BioCryst\u8217?s directors and officers and Idera\u8217?s directors and officers in the proposed mergers can be found in the\plain\cf1\f51\fs20\ql above-referenced Registration Statement. These documents may be obtained free of charge from the SEC\u8217?s website at\plain\cf1\f51\fs20\ql www.sec.gov,\~Idera\u8217?s website at www.iderapharma.com and BioCryst\u8217?s website at www.biocryst.com.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par
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\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\ql Forward-Looking Statements\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\ql This press release contains forward-looking statements within the meaning of the federal securities laws, including Section\~27A\plain\cf1\f51\fs20\ql of the Securities Act of 1933, as amended, and Section\~21E of the Securities Exchange Act of 1934, as amended. These\plain\cf1\f51\fs20\ql statements involve known and unknown risks, uncertainties and other factors which may cause actual results, performance or\plain\cf1\f51\fs20\ql achievements to be materially different from any future results, performances or achievements expressed or implied by the\plain\cf1\f51\fs20\ql forward-looking statements. These statements reflect our current views with respect to future events and are based on\plain\cf1\f51\fs20\ql assumptions and are subject to risks and uncertainties, and important factors that could cause actual events or results to differ\plain\cf1\f51\fs20\ql materially from Idera\u8217?s or BioCryst\u8217?s plans, estimates or expectations. Given these uncertainties, you should not\plain\cf1\f51\fs20\ql place undue reliance on these forward-looking statements. With respect to the transactions contemplated by the merger agreement\plain\cf1\f51\fs20\ql between Idera and BioCryst, these factors could include, but are not limited to: (i)\~Idera or BioCryst may be unable to obtain\plain\cf1\f51\fs20\ql stockholder approval as required for the mergers; (ii)\~conditions to the closing of the mergers may not be satisfied; (iii)\~the\plain\cf1\f51\fs20\ql mergers may involve unexpected costs, liabilities or delays; (iv)\~the effect of the announcement of the mergers on the ability of\plain\cf1\f51\fs20\ql Idera or BioCryst to retain and hire key personnel and maintain relationships with patients, doctors and others with whom Idera\plain\cf1\f51\fs20\ql or BioCryst does business, or on Idera\u8217?s or BioCryst\u8217?s operating results and business generally; (v)\~Idera\u8217?s or\plain\cf1\f51\fs20\ql BioCryst\u8217?s respective businesses may suffer as a result of uncertainty surrounding the mergers and disruption of\plain\cf1\f51\fs20\ql management\u8217?s attention due to the mergers; (vi)\~the outcome of any legal proceedings related to the mergers; (vii)\~Idera or\plain\cf1\f51\fs20\ql BioCryst may be adversely affected by other economic, business, and/or competitive factors; (viii)\~the occurrence of any event,\plain\cf1\f51\fs20\ql change or other circumstances that could give rise to the termination of the merger agreement; (ix)\~risks that the mergers disrupt\plain\cf1\f51\fs20\ql current plans and operations and the potential difficulties in employee retention as a result of the mergers; (x)\~the risk that Idera\plain\cf1\f51\fs20\ql or BioCryst may be unable to obtain governmental and regulatory approvals required for the transactions, or that required\plain\cf1\f51\fs20\ql governmental and regulatory approvals may delay the transactions or result in the imposition of conditions that could reduce the\plain\cf1\f51\fs20\ql anticipated benefits from the transactions contemplated by the merger agreement or cause the parties to abandon the transactions\plain\cf1\f51\fs20\ql contemplated by the merger agreement; (xi)\~risks that the anticipated benefits of the mergers or other commercial opportunities\plain\cf1\f51\fs20\ql may otherwise not be fully realized or may take longer to realize than expected; (xii)\~the impact of legislative, regulatory,\plain\cf1\f51\fs20\ql competitive and technological changes; (xiii)\~risks relating to the value of the new holding company shares to be issued in the\plain\cf1\f51\fs20\ql mergers; (xiv)\~expectations for future clinical trials, the timing and potential outcomes of clinical studies and interactions with\plain\cf1\f51\fs20\ql regulatory authorities; (xv)\~the risk that the credit ratings of the combined company or its subsidiaries may be different from what\plain\cf1\f51\fs20\ql the companies expect; (xvi)\~economic and foreign exchange rate volatility; (xvii)\~the continued strength of the medical and\plain\cf1\f51\fs20\ql pharmaceutical markets; (xviii)\~the timing, success and market reception for Idera\u8217?s and BioCryst\u8217?s products;\plain\cf1\f51\fs20\ql (xix)\~the possibility of new technologies outdating Idera\u8217?s or BioCryst\u8217?s products; (xx)\~continued support of\plain\cf1\f51\fs20\ql Idera\u8217?s or BioCryst\u8217?s products by influential medical professionals; (xxi)\~reliance on and integration of information\plain\cf1\f51\fs20\ql technology systems; (xxii)\~the risks associated with assumptions the parties make in connection with the parties\u8217? critical\plain\cf1\f51\fs20\ql accounting estimates and legal proceedings; (xxiii)\~the potential of international unrest, economic downturn or effects of\plain\cf1\f51\fs20\ql currencies, tax assessments, tax adjustments, anticipated tax rates, raw material costs or availability, benefit or retirement plan\plain\cf1\f51\fs20\ql costs, or other regulatory compliance costs; and (xxiv)\~other risks to the consummation of the mergers, including the risk that the\plain\cf1\f51\fs20\ql mergers will not be consummated within the expected time period or at all. These risks, as well as other risks associated with the\plain\cf1\f51\fs20\ql proposed mergers, are more fully discussed in the joint proxy statement/prospectus included in the Registration Statement filed\plain\cf1\f51\fs20\ql with the SEC in connection with the proposed mergers. While the list of factors presented here is, and the list of factors\plain\cf1\f51\fs20\ql presented in the Registration Statement are, considered representative, no such list should be considered a complete statement of\plain\cf1\f51\fs20\ql all potential risks and uncertainties. Unlisted factors may present significant additional obstacles to the realization of forward\plain\cf1\f51\fs20\ql looking statements. Consequences of material differences in results as compared with those anticipated in the forward-looking\plain\cf1\f51\fs20\ql statements could include, among other things, business disruption, operational problems, financial loss, legal liability to third\plain\cf1\f51\fs20\ql parties and similar risks, any of which could have a material adverse effect on BioCryst\u8217?s or Idera\u8217?s consolidated\plain\cf1\f51\fs20\ql financial condition, results of operations, credit rating or liquidity. Readers are urged to consider these factors carefully in\plain\cf1\f51\fs20\ql evaluating these forward-looking statements, and not to place undue reliance on any forward-looking statements. Readers should\plain\cf1\f51\fs20\ql also carefully review the risk factors described in other documents that Idera and BioCryst file from time to time with the SEC.\plain\cf1\f51\fs20\ql The forward-\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par
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\par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\ql looking statements in this document speak only as of the date of this document. Except as required by law,\~Idera and BioCryst\plain\cf1\f51\fs20\ql assume no obligation to update or revise these forward-looking statements for any reason, even if new information becomes\plain\cf1\f51\fs20\ql available in the future.\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\qc ###\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\ql BCRXW\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\ql Investor Contacts:\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\ql For BioCryst:\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\ql Thomas Staab
\par\pard\plain\fs16\pard\plain\cf1\f51\fs20\ql Senior Vice President, Chief Financial Officer
\par\pard\plain\fs16\pard\plain\cf1\f51\fs20\ql BioCryst Pharmaceuticals
\par\pard\plain\fs16\pard\plain\cf1\f51\fs20\ql Office: 919-859-7910
\par\pard\plain\fs16\pard\plain\cf1\f51\fs20\ql tstaab@biocryst.com\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\ql Additional Investor Contact:\par\pard\plain\cf1\f51\fs20\ql Scott Winter\par\pard\plain\cf1\f51\fs20\ql Innisfree M&A Incorporated\par\pard\plain\cf1\f51\fs20\ql Office: 212-750-7271\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\ql For Idera:\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\ql Robert Doody\par\pard\plain\cf1\f51\fs20\ql Vice President,\~Investor Relations and Corporate Communications\par\pard\plain\cf1\f51\fs20\ql Idera Pharmaceuticals\par\pard\plain\cf1\f51\fs20\ql Office: 617-679-5515\par\pard\plain\cf1\f51\fs20\ql Mobile: 484-639-7235\par\pard\plain\cf1\f51\fs20\ql rdoody@iderapharma.com\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\ql Additional Investor Contact:\par\pard\plain\cf1\f51\fs20\ql Bob Marese\par\pard\plain\cf1\f51\fs20\ql MacKenzie Partners,\~Inc.\par\pard\plain\cf1\f51\fs20\ql Office: 212-929-5500\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par}