mesna

mesna

[mes´nah]

a sulfhydryl compound given orally or intravenously together with a urotoxic antineoplastic agent such as ifosfamide or cyclophosphamide because it inactivates some of their metabolites and thus lessens damage to the bladder.

mesna

Mesnex, Uromitexan (CA) (UK)

Pharmacologic class: Detoxifying agent

Therapeutic class: Hemorrhagic cystitis inhibitor

Pregnancy risk category B

Action

Reacts in kidney with urotoxic ifosfamide metabolites (acrolein and 4-hydroxy-ifosfamide), resulting in their detoxification. Also binds to double bonds of acrolein and to other urotoxic metabolites.

Availability

Injection: 100 mg/ml in 10-ml vials

Tablets (coated): 400 mg

⊘Indications and dosages

➣ To prevent hemorrhagic cystitis in patients receiving ifosfamide

Adults:Combination I.V. and P.O. regimen-Single I.V. bolus dose of mesna at 20% of ifosfamide dosage, given at same time as ifosfamide, followed by two doses of mesna tablets P.O. at 40% of ifosfamide dosage given 2 and 6 hours after ifosfamide dose. I.V. regimen-I.V. bolus of mesna at 20% of ifosfamide dosage given at same time as ifosfamide, repeated 4 and 8 hours after each ifosfamide dose.

Patient teaching

• Inform patient that drug may cause significant adverse effects. Reassure him that he will be monitored closely.• Encourage patient to request analgesics or other pain-relief measures for headache, back or joint pain, hyperesthesia, or muscle ache.

mesna

/mes·na/ (mez´nah) a sulfhydryl compound given with urotoxic antineoplastic agents because it inactivates some of their urotoxic metabolites.

mesna

An agent that may act as an antioxidant, protecting the urogenital tract from toxic effects of ifosfamide and cyclophosphamide by binding them with its sulfhydryl-moieties, thereby reducing the incidence of haemorrhagic cystitis and haematuria.

mesna

mesna

A drug used to prevent damage to the urinary tract of people being treated with the anticancer drugs cyclophosphamide or ifosfamide. A brand name is Uromitexan.

Patient discussion about mesna

Q. my dad has msa, he has recently started seeing things, eg aliens, government consp.ext not fully reconzing lov does not reconize loved ones while having these episodes, becomes anxious and ill manered just not like my dad at all, he's so quite and polite normally.

A. Multi Systems Atrophy = MSA

Try this:http://www.credencegroup.co.uk/Eclub/ses/sessearch.php?q=atrophy&pvdc=0Get in touch with the credence group - they know very very much.

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