The rune crossbow is the second strongest crossbow in the game, behind the Armadyl crossbow. Requiring 61 Ranged to wield, It can fire up to and including Runite bolts. It is equipable with a shield, a great advantage for player killing, and fighting monsters such as dragons which require an anti-dragon shield.

Offers a powerful special attack, where if used with dragon arrows, it increases damage dealt by 50% with a minimum hit of 8 (30% with any other arrow with a minimum hit of 5). Costs 55% special attack energy.