*Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis

*Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis

−

''Under phosphotransferase activity, alcohol group as acceptor''

+

''Phosphotransferase activity, alcohol group as acceptor''

+

<br/>

4. RET

4. RET

*This gene plays a crucial role in neural crest development, and it can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement.

*This gene plays a crucial role in neural crest development, and it can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement.

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5. FGFR4

5. FGFR4

*This particular family member preferentially binds acidic fibroblast growth factor and, although its specific function is unknown, it is overexpressed in gynecological tumor samples, suggesting a role in breast and ovarian tumorigenesis.

*This particular family member preferentially binds acidic fibroblast growth factor and, although its specific function is unknown, it is overexpressed in gynecological tumor samples, suggesting a role in breast and ovarian tumorigenesis.

−

6. CDK1A

+

6. CDKN1A

*The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1.

*The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1.

*The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli.

*The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli.

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*May be instrumental in the execution of apoptosis following caspase activation.

*May be instrumental in the execution of apoptosis following caspase activation.

'''SK-N-SH RA'''

'''SK-N-SH RA'''

−

''All under signaling receptor activity''

+

<br/>

+

''Signaling receptor activity''

+

<br/>

1. KIT

1. KIT

*This gene encodes the human homolog of the proto-oncogene c-kit. C-kit was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit.

*This gene encodes the human homolog of the proto-oncogene c-kit. C-kit was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit.

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*Mutations in this gene are associated with lung cancer.

*Mutations in this gene are associated with lung cancer.

''Sequence-Specific DNA Binding''

''Sequence-Specific DNA Binding''

+

<br/>

4. WT1

4. WT1

*It is mutated in a small subset of patients with Wilm's tumors

*It is mutated in a small subset of patients with Wilm's tumors

Latest revision as of 22:16, 26 September 2017

Genes of Focus

There is a threshold of > 10^-3
HepG2

TBD

K562MAP Kinase Activity
1. MAPK14

The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response.

2. MAPK9

Involved in UV radiation induced apoptosis, thought to be related to the cytochrome c-mediated cell death pathway

This kinase blocks the ubiquitination of tumor suppressor p53, and thus it increases the stability of p53 in nonstressed cells

3. MAPK10

Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis

Phosphotransferase activity, alcohol group as acceptor
4. RET

This gene plays a crucial role in neural crest development, and it can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement.

This particular family member preferentially binds acidic fibroblast growth factor and, although its specific function is unknown, it is overexpressed in gynecological tumor samples, suggesting a role in breast and ovarian tumorigenesis.

6. CDKN1A

The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1.

The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli.

Plays a regulatory role in S phase DNA replication and DNA damage repair.

May be instrumental in the execution of apoptosis following caspase activation.

SK-N-SH RASignaling receptor activity
1. KIT

This gene encodes the human homolog of the proto-oncogene c-kit. C-kit was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit.