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Targeted Drug Therapies during Adolescence May Be Used to Normalize Synapse Number
in the Brains of Individuals with Abnormal Numbers of Synapses, Such As Found in Schizophrenia
and Autism

Brooklyn, NY – Memories are formed at structures in the brain known as dendritic spines,
which communicate with other brain cells through “synapses.” The number of these brain
connections decreases by half after puberty in a process termed adolescent “synaptic
pruning” that is necessary for normal learning in adulthood. However, the pruning
away of unnecessary synapses does not follow the normal process in diseases such as
autism and schizophrenia, where the abnormality is thought to underlie many of the
cognitive impairments associated with these disorders.

Researchers at SUNY Downstate Medical Center recently discovered that an inhibitory
brain receptor triggers pruning in adolescence in a pre-clinical model. Now, a new
article by the SUNY Downstate researchers shows that drugs that selectively target
these receptors, when administered during adolescence, can alter synapse number.

Dr. Smith adds, “These findings suggest that targeted drug therapies during adolescence
could potentially be used to normalize synapse number in the brains of individuals
with abnormal numbers of synapses, such as found in autism and schizophrenia.” Dr.
Smith cautions, however, that at this time such drugs are not yet available for use
in humans.

The research leading to the results published by Neuroscience was supported by the National Institutes of Health/National Institute of Mental Health,
Award Number R01-MH100561, to Sheryl S. Smith. The content is solely the responsibility
of the authors and does not necessarily represent the official views of the National
Institute of Mental Health or National Institutes of Health.Copies of this paper are available to credentialed journalists upon request; please
contact Elsevier's Newsroom at newsroom@elsevier.com or +31 20 485 2492.

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About SUNY Downstate Medical Center

SUNY Downstate Medical Center, founded in 1860, was the first medical school in the
United States to bring teaching out of the lecture hall and to the patient’s bedside.
A center of innovation and excellence in research and clinical service delivery, SUNY
Downstate Medical Center comprises a College of Medicine, College of Nursing, School
of Health Professions, a School of Graduate Studies, School of Public Health, University
Hospital of Brooklyn, and a multifaceted biotechnology initiative including the Downstate
Biotechnology Incubator and BioBAT for early-stage and more mature companies, respectively.

SUNY Downstate ranks twelfth nationally in the number of alumni who are on the faculty
of American medical schools. More physicians practicing in New York City have graduated
from SUNY Downstate than from any other medical school.