Clinical Trials

Losartan Effects on Emphysema Progression (LEEP) Trial

Institution:

Nationwide

Type:

Multi-Center Trial

Purpose:

The American Lung Association sponsors studies of treatments for COPD to help find ways to make people’s lives better. Right now the Lung Association is sponsoring a clinical study of a possible treatment for COPD with emphysema. The drug being tested is Losartan. Losartan is a drug commonly used to treat high blood pressure. Results from early studies suggest that Losartan may actually slow damage to the lungs caused by emphysema related to COPD.

Dates:

May 1, 2015

Disease:

COPD

About the study:

More research needs to be done to understand the effect Losartan may have on the lungs. As a next step, the American Lung Association network of Airways Clinical Research Centers (ACRC) a conducting a multicenter randomized trial. This study will compare Losartan versus a placebo in people with emphysema. The study will use high-resolution CT scans (HRCT) to see if Losartan slows the progression of emphysema.

How does the study work?

People who are eligible for the study and agree to join will be randomly assigned to receive Losartan or placebo for one year. Patients will receive HRCTs at the beginning and end of the study.

Who is eligible to enroll in the study?

We are looking for adults 40 years of age or older with COPD to join our study. The Losartan Effect on Emphysema Progression (LEEP) trial is being conducted at ACRC centers around the country. A list of centers is provided below. People who enroll will need to go to the study site every three months for one year.

Does it cost anything to enroll?

It is free to enroll in this study. Supplies of Losartan will be provided by the study free of charge. Study participants will receive payments for their time and expenses, and there will be no charges for study visits or clinical examinations.

The study is sponsored by the American Lung Association and the National Heart Lung and Blood Institute (NHLBI). If you are interested in learning more about joining this important study, please contact the center closest to you.