The 1876 Democratic National Convention assembled in St. Louis just nine days after the conclusion of the Republican National Convention in Cincinnati.

This was the first political convention held west of the Mississippi River. St. Louis was notified in February 1876 that it had been selected. Among the events was a fireworks display from the top of the Old Courthouse.

Interior of the Merchants Exchange Building of St. Louis, Missouri, during the announcement of Samuel J. Tilden as the Democratic presidential nominee

The 12th Democratic National Convention assembled in St. Louis in June 1876. Five thousand people jammed the auditorium in St. Louis, hoping for the Democrats' first presidential victory in 20 years. The platform called for immediate and sweeping reforms following the scandal-plagued Grant administration. Tilden won more than 400 votes on the first ballot and the nomination by a landslide on the second.

Thomas Hendricks was the only individual nominated for vice-president, and received the nomination almost unanimously on the first ballot. The delegation from Ohio had thought of offering the name of one of her distinguished sons, Henry B. Payne. However, the feeling of unanimity was so great that the Ohio delegation declined to present his name and seconded the nomination of Hendricks. But when the roll call vote took place, Ohio cast 8 blank ballots.

The Democratic platform pledged to replace the corruption of the Grant administration with honest, efficient government and to end "the rapacity of carpetbag tyrannies" in the South; called for treaty protection for naturalized U.S. citizens visiting their homeland, restrictions on Oriental immigration, and tariff reform; and opposed land grants to railroads.[2]