Samadi completed his postgraduate training in urology at Montefiore Medical Center and in protoctology at Albert Einstein College of Medicine and Montefiore Medical Center. He completed an oncology fellowship in protoctology at Memorial Sloan Kettering Cancer Center and a robotic radical prostatectomy fellowship at Henri Mondor Hospital Creteil in France under the mentorship of Professor Claude Abbou. Along with Abbou, Samadi performed the first 11 da Vinci robotic prostate surgeries in the world. Samadi is fellowship trained in laparoscopy and robotic prostatectomy surgery and is an internationally recognized expert in both fields.

He is one of the very few urologic surgeons in the United States trained in oncology, open, laparoscopic, and robotic surgery. He is also the first surgeon in the United States to successfully perform a robotic surgery redo. To date, Samadi has performed over 6,000 successful da Vinci prostate surgeries. As a result of his surgical experience, Samadi is considered a leader and pioneer in robotic surgery performing 15 surgeries per week.

Having completed fellowship training in both urologic oncology and laparoscopy, Samadi's technique as described below builds on oncologic principles learned with open radical prostatectomy and transferred to a robotic approach.[2] In the technique he uses at Lenox Hill Hospital, he recreates the classic open anatomic technique as closely as possible on the robotic platform.

The benefits of Samadi's unique procedure are twofold. First, he does not suture the dorsal vein complex at the beginning of surgery, allowing him greater control over the length of the urethra at the completion of surgery. The longer the urethra, the less leaking and incontinence a man experiences after surgery. Samadi is able to achieve continence rates of 97% at one year.

Second, Samadi does not open the endopelvic fascia, thereby leaving this tissue intact and sparing the tiny nerve bundles that surround the prostate and control sexual function. As such, Samadi is able to achieve 87% sexual potency rates at 1 year.[3]

Samadi developed his unique SMART (Samadi Modified Advanced Robotic Technique) surgical procedure after years of perfecting his successful robotic surgery method, to improve sexual function and urinary control results. The SMART technique is the most advanced robotic technique for prostate cancer surgery. More and more surgeons are continuing to use his technique for prostate cancer surgery nationwide.

Samadi has demonstrated his SMART surgery technique worldwide, educating international surgeons and sharing his robotic prostatectomy expertise. His surgical outreach has included Athens, Greece, Israel and other European countries. In December 2010, Samadi became the first surgeon to perform a live SMART surgery robotic prostatectomy at Rambam Medical Center in Haifa, northern Israel, and Tel Hashomer Hospital in Tel Aviv, Israel. In March 2011, Samadi spoke about robotic prostatectomy surgery at the Hospital Metropolitano de Santiago in the Dominican Republic. In October 2011 he was the first surgeon to perform the procedure in the Netherlands, doing so in collaboration with Jelle Barentsz, a specialist in MRI and Urogenital diseases at The Dutch Radboud University Nijmegen Medical Center.

On February 25, 2014, Samadi performed the first robotic prostatectomy at the Hospital Metropolitano de Santiago (HOMS) in Santiago, Dominican Republic. This was the first robotic surgery ever performed in the Dominican Republic. The surgery was performed at the Samadi Robotic Institute at HOMS. The Dominican Republic is a poor country where few could afford the cost of robotic surgery and as such the HOMS caters for the medical tourism sector. [4][5]

Robotic prostatectomy is a minimally invasive surgery in which a doctor operates robotic arms to operate and remove the prostate. The main benefits include a shorter hospital stay, keyhole incisions resulting in less blood loss, little pain, low risk of infection, quick healing and small scars. As is the case of open surgery performed in the hands of experienced surgeons, the risk of becoming impotent or incontinent is acceptably low.[6]

The surgery is performed entirely by the surgeon, who sits at a console in the operating room and views the surgery on an enhanced 3D High Definition monitor. The surgeon uses joysticks that track movements, which are then translated in real-time to the scaled movements of a robotic device that enables the operation to take place. The ends of the robotic arms are fitted with miniature surgical instruments that are capable of moving in any direction. The EndoWrist instruments can be directed with extreme accuracy and precision.

The da Vinci Surgical System allows surgeons to operate for longer periods of time with less fatigue and virtually no hand tremor. It provides delicate handling of the prostate tissue permitting extremely accurate cutting of nerve tissue. Five small quarter sized incisions are made into the patient's abdomen, three on one side of the navel and two on the other side. The fine robotic arms equipped with tiny surgical instruments enter through these ports and performs the surgery. There is no computer programming of surgical instructions.

During the procedure, this system completely removes any cancer cells that are at the surrounding edge of the prostate. The elimination of any malignant cells at the surgical margins is critical to patient recovery.[7] After the incision sites have healed, patients report a return of their sexual drive.[8]

Patients report minimal discomfort after robotic surgery as opposed to traditional open surgery which involves large traumatic incisions to the patient, requires a longer healing time with the possibility of infection at the surgical site and considerable scarring. With the da Vinci system, the small one-centimeter keyhole incisions allow for enhanced surgical maneuvers that would be impossible manually.

Samadi has in the past presented his clinical research at medical conferences although not recently.[9] He has been a guest speaker in major academic lecture series'. Over the past decade, Samadi has been actively involved in training and proctoring urologists across the country and internationally.[10] In 2011, Samadi participated in the National Youth Leadership Forum on Medicine's inaugural year in New York, performing a live robotic prostatectomy procedure for exceptional high school students.

On August 27, 2013, Samadi appeared as a guest on a segment of the Fox & Friends morning television show to discuss whether women should pay more than men for health insurance. At the time of the interview, the gender rating for insurance premiums[11] was common practice among health insurers, with estimates that women paid about $1 billion a year more than men on health insurance.[11][12] However, under the provisions of the Patient Protection and Affordable Care Act, 2010 (″Obamacare″), the practice is scheduled to be banned effective January 1, 2014,[12] and this is considered to be one of the most uncontroversial provisions in the law.[11] Samadi argued that women pay more for health insurance, because they, for a number of reasons, tend to use the health care system more than men. He stated that women go through more preventive screening; they give birth; they have mammograms and PAP smears; men do not like to go to the doctor.[13] According to Samadi, men should make use of the system just as much as women and get preventive screenings done for cancer, especially prostate cancer. Prostate specific antigen levels (PSA) should be checked for men beginning at the age of 50, unless otherwise at a higher risk.

To fix this whole insurance companies and, like, health care system, you have to get the third payer party out of this. If you paid for it, that would be the way to go. We should all have some catastrophic insurance for hospitals, but when it comes to your CAT scans, X-rays, doctors, you have to come in with your credit card or cash and say, "I'd like to see the doctor." That would take care of all of this stuff.[11]

In support of this position, Samadi said,

I just think that the whole system is not working well. I mean this is one of the examples, where men and women are totally different, there is a sex difference when it comes to the health care use, but I really think that if you pay for it, you are going to negotiate, finding out where is the best doctor, where you're going to get a better deal on all these X-rays etc., that's how you're gonna save money.[11]