MIP Technologies AB has developed
a new resin for silver ion chromatography, RENSA® 101.
The surface of the material contains hydrophobic moieties along
with silver ions bound to a sulfonic acid functionality.

The designed resin RENSA® 103 is a novel type of strong cation
exchanger. Unlike most conventional ion exchangers, the material is characterized by a high cross-linking degree and an alternative route of incorporation of the ionic moieties. MIP

MIP Technologies AB (a subsidiary of Biotage AB) has developed
a new type of affinity resin, RENSA® Boronate (Figure 1)
with selective boronic acid surface functional groups. It has
an optimized distribution and accessibility of hydrophobic
(phenyl) and selective boronic acid moieties (Figure 2). It is
produced by a proprietary particle synthesis technology and
exhibits a material architecture and pore size distribution that is
optimized for binding of small and oligomeric molecules.

RENSA® OH is a highly cross-linked methacrylic polymeric
resin in bead form. The porosity is optimized to
allow access to small organic molecules and also oligomeric
compounds. The resin is rigid due to the high degree of crosslinking and has a hydrophilic surface character due to abundant hydroxyethyl functional groups on the polymer backbone. MIP

RENSA® polymeric resins are synthetic, polymeric materials with the ability to interact with a wide scope of chemical and biological compounds. They are insoluble, spherical particles with an engineered internal porous structure. RENSA materials are produced by novel synthetic methods that lead to superior material architectures with optimal internal porosity and distribution of surface functional groups.

MIP Technologies AB (a subsidiary of Biotage AB) has developed
a new type of mixed mode polymer resin, RENSA® PX
(Figure 1). It is produced by a proprietary particle synthesis
technology, to yield highly cross-linked polystyrene particles
containing easily accessible imidazole moieties on the bead
surface (Figure 2). The resin exhibits a material architecture
whose porosity (Figure 3) and distribution of phenyl and
imidazole moieties are optimized to retain a broad range of
molecules from a liquid matrix.

Penicillin G and its degradation products 6-APA and PAA were separated on a new type of polymeric resin, RENSA® PY. In this proof-of-concept study, RENSA® PY outperformed two commercially available resins.

Purifying peptides from crude synthetic mixtures can be extremely challenging. The peptides often need to be separated from side products, (deletion and truncated sequences generated during the synthesis) some of which may possess nearly identical sequences. Biotage has a long history in traditional chromatographic separation. Biotage now offers Resolux reversed-phase HPLC columns as an ideal solution for separation of synthetic peptides. The Resolux HPLC columns provide excellent resolution and are an economical choice for the peptide chemist.

Reversed-phase chromatography facilitates the isolation of milligram to multi-gram quantities of polar compounds from naturally occurring materials or from synthetic reaction
products. Biotage reversed phase KP-C18-HS SNAP cartridges have been shown in a number of applications to be effective for the purification of natural products. The methodology is robust and may
be applied generically to new extraction purification runs.
Keywords: natural, products, reversed, phase, normal, extraction, spinach.

Normal-phase flash chromatography1 has been widely adopted as the method of choice for separation of product mixtures and reaction by-products. One of the most significant developments in this
area concerns the practical separation of polar molecules. Reversed-phase purification is a modification of normalphase
chromatography that provides an efficient mechanism for the separation of polar compounds.

Rink Amide-ChemMatrix is one of the most popular resins for for
both manual SPPS and automated SPPS, under microwave or
non-microwave conditions. For microwave synthesis, we also
recommend the use of PAL-ChemMatrix resin which can also
provide crude product in high purity.

About Biotage

Biotage offers products and services within three areas – Organic Chemistry, Analytical Chemistry and Industrial Resins. The Company’s offering is oriented toward an international market, and the majority of the Company’s sales are generated outside Sweden. The Biotage share is listed on the NASDAQ OMX Stockholm Small Cap list.