The latest generation tcVisualize software now offers wide support for variable dosing, cross-protocol drug pooling, Monte Carlo simulations, and adaptive trial designs. Among many other enhancements, the 3.0 release also expands modeling up the supply chain to include pharmaceutical ingredients and other kit components.

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The Monte Carlo capabilities of tcVisualize 3.0, developed with close involvement of some of the world's premiere bio-statisticians, increase the accuracy of modeling significantly - and are key to the support of adaptive trials. Monte Carlo statistical techniques allow the application to simulate a multiplicity of scenarios, weigh the possibilities, and deliver answers with high - and specific - degrees of confidence.

"I'm proud that our team was able to pack so many significant advances into a single release of tcVisualize," said Ed Tourtellotte, CEO of Tourtellotte Solutions. "We're giving clients broader functionality - and far greater power - than they can get anywhere else."

One of the most significant of tcVisualize 3.0's new features is its support of variable dosing (variable titration) trials, which are in increasing use by many biopharmaceuticals. tcVisualize 3.0 is the only tool that can model and compare scenarios around the intricacies of unpredictable dosing, allowing users to avoid the usual supply crises and excess overage.

Also new is tcVisualize 3.0's support of drug pooling, an emerging supply technique that reduces waste and minimizes risk by allowing supply and safety stock to be shared among protocols. tcVisualize 3.0 can be configured to simulate multiple studies simultaneously so that stock can be shared at specified depots and even sites.

One of tcVisualize 3.0's many smaller enhancements is its new ability to model the usage of active pharmaceutical ingredients (or any other constituent element) in dispensing units, and to report consumption at both the dispensing unit and constituent level. This is the first step in a direction that is of great interest to the industry: a clinical manufacturing demand plan at the enterprise level, driven by reliable study models. Tourtellotte Solutions will be pursuing this aggressively in future releases of tcVisualize.