Effect of Cardiac Computed Tomography Angiography on the Blood Reactive Oxygen Species Level

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ClinicalTrials.gov Identifier: NCT00815230

Recruitment Status
:
Withdrawn
(because of unexpected administrative barrier, it was very difficult to enroll case.)

Effect of Cardiac Computed Tomography Angiography on the Blood Reactive Oxygen Species Level

Official Title

Effect of Cardiac Computed Tomography Angiography on the Blood Reactive Oxygen Species Level

Brief Summary

The clinically widely used X-ray computed tomography examination has a low-grade radiation effect and recently has attracted much attention concerning the possible adverse effects of radiation on human body [ref. 1-5]. The radiation is harmful to human tissues and cells mainly because it can interact with water (which makes up to 80% of cells) to generate reactive oxygen species (ROS), especially the formation of hydroxyl radicals. So far as we can reach, there is no report concerning the relation between X-ray computed tomography examination and the blood ROS level. Therefore, we wish to conduct this study to clarify if the cardiac computed tomography angiography (cardiac CTA) may induce a higher level of ROS in the peripheral blood.

Study subjects will be OPD patients who are arranged for cardiac CTA examination because of suspect coronary artery disease (CAD). In total, twenty cases will be enrolled for the study. The formal consent will be delivered and explained to the patients and families after the arrangement of cardiac CTA. It then will be retrieved just before the performance of cardiac CTA.

For each enrolled case, peripheral blood will be sampled three times (once before and twice after the performance of cardiac CTA). Totally 60 blood samples will be collected from 20 study subjects within 3 months (January 1 ~ March 31, 2009). ROS level in the collected blood samples will be then measured, compared, and analyzed.

Detailed Description

Not Provided

Study Type

Observational

Study Design

Observational Model: Case-OnlyTime Perspective: Prospective

Target Follow-Up Duration

Not Provided

Biospecimen

Retention: None Retained

Description:

only peripheral blood will be collected for measurement of reactive oxygen species.

Sampling Method

Non-Probability Sample

Study Population

Study subjects will be OPD patients who are arranged for cardiac CTA examination because of suspect coronary artery disease.

Condition

Radiation Injury

Intervention

Not Provided

Study Groups/Cohorts

Not Provided

Publications *

Not Provided

* Includes publications given by the data provider as well as publications
identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.

Recruitment Information

Recruitment Status

Withdrawn

Estimated Enrollment

20

Estimated Completion Date

March 2009

Primary Completion Date

Not Provided

Eligibility Criteria

Inclusion Criteria:

subjects who are arranged for cardiac CTA examination because of suspect coronary artery disease.

Exclusion Criteria:

Sex/Gender

Sexes Eligible for Study:

All

Ages

20 Years to 80 Years (Adult, Senior)

Accepts Healthy Volunteers

Yes

Contacts

Contact information is only displayed when the study is recruiting subjects