Senior Member

They appear to say that IL6 is good if as a result of intense exercise but as pwME never engage in intense activity it's bad because without intense exercise it's an inflamitory which can cause muscle wasting amongst all the other wonderful side effects of inflamation in pwME.

Cloud

Guest

They appear to say that IL6 is good if as a result of intense exercise but as pwME never engage in intense activity it's bad because without intense exercise it's an inflamitory which can cause muscle wasting amongst all the other wonderful side effects of inflamation in pwME.

I understood it to say that the increased levels of IL6 and TNF in ME/CFS causes the development of more receptors for these cytokines, which may perpetuate the problem by encouraging an even greater release of IL6 and TNF, in particular, with exertion. But, I may need to read it more closely as well.

I have always favored the idea of "Cytokine Storm" being primary cause of my symptoms, especially PEM. I had never read about this idea of growing additional receptors to meet the need of the increased levels of cytokines. It just made a lot of sense to me. And it seems a logical direction for the pursuit of Tx ideas.