Engineering the Human Germline

An Exploration of the Science and Ethics of Altering the Genes We Pass to Our Children

Edited by Gregory Stock and John Campbell

This accessible and challenging book looks beyond the immediate question of cloning to the broader questions of using genetic engineering to alter the evolution of the human species. The book covers both the hands-on scientific details and the many ethical and social concerns. It includes a discussion of recent successes in cloning large animals and examines the implications for medicine and for our future. Contributors include many of the world leaders in the field: Lee Hood, French Anderson, Mario Capecchi, Dan Koshland, Michael Rose, Lee Silver, and James Watson.

Engineering the Human Germline

An Exploration of the Science and Ethics of Altering the Genes We Pass to Our Children

Edited by Gregory Stock and John Campbell

Description

This book explores the many prospects, challenges and ethical questions that surround the engineering of our reproductive cells. It is an accessible, three-part examination, moving from focused, realistic assessments of the promise and problems for this advancing technology to a section of short essays on the implications of our technological ability. Also included is a panel discussion in which leading scientists, ethicists, and public policy workers give voice to their thoughts and concerns regarding our impending genetic technologies. Many world leaders in these fields, including Leroy Hood, French Anderson, Mario Capecchi, Daniel Koshland, Michael Rose, Lee Silver, and James Watson, have contributed to this volume, providing the essential elements of the
debate over germline engineering. If you have ever pondered the question: "Would I be willing to genetically alter my own child-to-be, given a safe, reliable technology, offering a tempting possibility?", this book will be an indispensable guide.

Engineering the Human Germline

An Exploration of the Science and Ethics of Altering the Genes We Pass to Our Children

Edited by Gregory Stock and John Campbell

Table of Contents

ContributorsIntroduction: An Evolutionary PerspectiveI. THE REALITIES OF HUMAN GERMLINE ENGINEERING A Vision for Practical Human Germline Engineering, John Campbell and Gregory StockThe Human Genome Project--Launch Pad for Human Genetic Engineering, Leroy HoodEthics and Safety, Daniel Koshland, Jr.Human Germline Gene Therapy: How and Why, Mario R. CapecchiA New Front in the Battle against Disease, W. French AndersonAging as a Target for Genetic Engineering, Michael R. RoseReprogenetics: How Reproductive and Genetic Technologies Will Be Combined to Provide New Opportunities for People to Reach Their Reproductive Goals, Lee M. SilverII. THE ROAD AHEAD A Panel Discussion, John Campbell et al.III. OTHERVOICES Beyond the Issue of Safety, Glenn McGee et al.Long-Term Possibilities and Dangers, Alex Mauron et al.Regulation and Jurisdiction, Darryl Macer and Lloyd CohenAppendix: Select Questions from the Public to Participants in the "Engineering the Human Germline" SymposiumNotesGlossaryIndex

Engineering the Human Germline

An Exploration of the Science and Ethics of Altering the Genes We Pass to Our Children

Edited by Gregory Stock and John Campbell

Reviews and Awards

"It is unique among books published on recent genetic advancements and their impact on society. First, it is one of only a few on this controversial topic; and second, it contains opinions not only for prominent researchers, but also for ethicists and policy makers."--Annals, March 2001

"A short, readable, thought-provoking book that discusses in nontechnical terms the future of humankind in an age of genetic engineering and should be read by anyone who wishes to participate in a public discourse that will shape the future....Essays by 17 authors [capture] a broad spectrum of expertise and opinion."--The New England Journal of Medicine

"Three approaches to looking at the possibilities and dangers of manipulating genes in reproductive cells to alter both immediate patients and their offspring. First, seven scientists explain to general readers the state of the science and technology, distinguishing what is possible from what is unlikely or impossible. Then they are joined by an ethicist, a public policy specialist, and Nobel-laureate James Watson for a lively panel discussion. Finally a collection of short essays by scientists, ethicists, lawyers, theologians, and public-policy makers offer a wide range of views."--SciTech Book News

"Paints a futuristic picture of the 'practical aspects' of genome manipulation."--Nature

"Attempts to correct human diseases by inserting engineered genes into somatic, or body, cells began nearly a decade ago. In contrast, the idea of introducing manipulated genes into germline, or sex, cells has generally been taboo, since this would alter the genetic makeup of future generations. Unfortunately, somatic cell gene therapy has so far proved frustrating, and therefore in 1998 the editors convened the first major public forum to discuss the prospects of human germline gene therapy--a seemingly more straightforward approach to curing genetic disease. ... These papers balance the generally favorable statements for human germline engineering presented in the first two sections and are especially useful in appreciating the complexity and broad implications of this
potential technology. General readers; lower-division undergraduates."--Choice

"This is an interesting, informative and often unsettling look at current and future genetic manipulation. Could the same techniques used for gene therapy be used to enhance traits? This text takes us further. Although the participants are predominantly American, an international perspective is attempted. The reader is left pondering the question presented to the participants: If you could do so safely, would you use an artificial chromosome to extend the lifespan of your child?" -- Laura T. Arbour, MD, Clin Invest Med, Vol 23, No 6, Dec 2000

"This lively and frank analysis of germline genetic manipulations of reproductive cells fascinates by virtue of the fact that it constitues one of the first in-depth analyses of the realistic possibilities and problems of this technology... replete with academicians...who lay the ground work for a better understanding of "genetic engineering." No uniformity of approach or ideas emerges, a true reflection of the controversial nature but also of the scientific uncertainty still surrounding this technology. The second part of the book is livelier, its debate format slipping out of the arena of typical "pros and cons" arguments to reveal the personal insights and values of the aforementioned. Discussion throughout is frank and open. The ethical evaluation of the purposes and
implications of germline engineering lies in the careful, cautious, and courageous discernment of its purposes and implications as found in this book." -- Bartha Maria Knoppers, Nature Biotechnology, Vol 18, Oct 2000

"Over the past years new reproductive and molecular technologies, concurrent with progress in the human genome project, have provided a scientific foundation for speculation about manipulation of the human genome. . .In an apparent attempt to address our mixed feelings about human genetic manipulation, the present book is published. This three part volume tries to address our state of scientific progress in germ-line genetic modification."--Heredity Journal