Ian S. Maze, Ph.D., is a neurobiologist with extensive training in the molecular biology and chromatin biochemistry of histone regulation in the mammalian central nervous system. His multidisciplinary and integrative research involves the use of biochemical, biophysical, physiological and behavioral analyses to explore the molecular underpinnings of neurodevelopmental and adult cognitive and psychiatric disorders. Dr. Maze is actively investigating the brains of rodents and postmortem humans, as well as human iPSC-derived neurons, to uncover chromatin-based mechanisms of neurological disease.

The Maze laboratory is focused on understanding the role of chromatin dynamics, nucleosomal turnover and histone variant exchange in the central nervous system during periods of transcriptional, synaptic and behavioral plasticity. Extended emphasis is placed on investigating the functions of novel neuronal specific/enriched histone modifications and ‘reader’ proteins, as well as their role in developmental neurological disorders (e.g. Down syndrome) and adult psychiatric illness. Current projects include the utilization of chromatin biochemical techniques, genome-wide sequencing analyses and viral vector-based gene modification systems to investigate novel histone-based mechanisms of monoaminergic dysfunction in major depressive disorder. Search PubMed for publications

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Dr. Maze has not yet completed reporting of Industry relationships.

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