The bridge is named for 16th century Spanish explorer Hernando de Soto who explored this stretch of the Mississippi River, and died south of Memphis. His body was believed to have been buried in the Mississippi River after his death (although, according to legend, his body lay at the bottom of Lake Chicot in Arkansas, an oxbow lake of the Mississippi River about 130 miles south of Memphis.)

On August 27, 2007, an inspector discovered that a bridge pier on the approach bridge west of the river had settled overnight, and the bridge was subsequently closed to perform a precautionary inspection. The bridge was reopened later that day. [2]

View of the Hernando de Soto Bridge from the south eastern shores of the river Mississippi