Diabetes med 'helps reduce BMI in obese teens'

Published: Tuesday, February 2, 2010, 15:17 [IST]

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Washington, Feb 2 (ANI): A medication used to treat type 2 diabetes causes a small but significant decrease in body mass index (BMI) in non-diabetic obese adolescents when combined with a lifestyle intervention program, says a new study.

The study on Metformin XR (extended release formulation) has been published in the February issue of Archives of Pediatrics and Adolescent Medicine, one of the JAMA/Archives journals.

Metformin hydrochloride is commonly used to treat obesity in non-diabetic adolescents, but there is not enough data available to confirm its efficacy as an obesity treatment.

To reach the conclusion, Darrell M. Wilson, M.D., of Stanford University and the Lucile S. Packard Children's Hospital, Stanford, Calif., and colleagues in the Glaser Pediatric Research Network Obesity Study Group randomly assigned 77 obese adolescents (ages 13 to 18) to a lifestyle intervention program (consisting of physical activity and diet) and either one daily dose of metformin XR (2,000 milligrams) (39 patients) or placebo (38 patients) for 48 weeks. Participants were monitored for an additional 48 weeks.

"Metformin XR had a small but statistically significant impact on BMI over the initial 52 weeks of the study," the authors write. The average BMI increased by 0.2 in the placebo group and decreased by 0.9 in the metformin XR group. "The BMI difference between the groups persisted for 12 to 24 weeks after cessation of study drug. Thereafter, the mean [average] BMI in the metformin group increased toward that in the control group."

"Metformin was safe and tolerated in this population. These results indicate that metformin may have an important role in the treatment of adolescent obesity," the authors conclude. "Longer-term studies will be needed to define the effects of metformin treatment on obesity-related disease risk in this population." (ANI)