2017.02.14 조회 수 : 841마감일 : 2017.04.30

Title: Medicinal Chemistry Postdoctoral Fellowship at NCI, NIH

A postdoctoral fellowship in the field of medicinal chemistry is immediately available to carry out structure-based drug design and hit-to-lead optimization on several promising hits against polo-like kinase 1 (Plk1). Plk1 is an attractive anti-cancer therapeutic target, whose upregulated activity is tightly associated with aggressiveness and poor prognosis for a wide spectrum of human cancers. We performed high throughput screening campaigns at the at the National Center for Advancing Translational Sciences (NCATS) (https://ncats.nih.gov/), and isolated a new class of several anti-Plk1 small molecule compounds, whose cocrystal structures have been determined lately. In an effort to discover novel Plk1-targeted anti-cancer therapeutic agents, we have developed an NCI’s multifaceted collaboration project by bringing together various expertise, including medicinal chemistry optimization, X-ray crystallography, in silico modeling, pharmacokinetics/pharmacodynamics, and mouse tumorigenesis studies. Once appointed, the fellow will primarily work in the synthetic chemistry lab at NCATS under the direct guidance of Dr. David Maloney (https://ncats.nih.gov/staff/maloneyd), the medicinal chemistry leader at NCATS, and Dr. Kyung Lee (https://ccr.cancer.gov/Laboratory-of-Metabolism/kyung-s-lee) in the Laboratory of Metabolism, NCI, and will have an opportunity to interact with other collaboration teams involved in this interdisciplinary project.

Applicants should have (or expected to receive) a Ph.D. or its equivalent at the time of joining the lab or have achieved the degree less than 3 years ago. Fellows who have an expertise in medicinal chemistry optimization of small molecule inhibitors or X-ray crystallography are encouraged to apply. Salary starts at $51,900 with full health insurance for fellows with no prior postdoctoral training.