London, 1913—the era of Sherlock Holmes, Dracula, and the Invisible Man. A time of shadows, secret societies, and dens filled with opium addicts. Into this world comes the most fantastic emissary of evil society has ever known… Dr. Fu-Manchu.

Denis Nayland Smith pursues his quarry across continents and through the back alleys of London. As victim after victim disappears at the hands of the Devil Doctor, Smith must unravel his murderous plot before it is too late.