Writer Warren Farrell compared the dehumanizing stereotyping of men to the dehumanization of American slaves, stating that the male role in most traditional societies is similar to the role of the second class slave, while the female role is similar to the first class slave. The second class slave would labor outside, while the first class slave worked in the home.

In the past quarter century, we exposed biases against other races and called it racism, and we exposed biases against women and called it sexism. Biases against men we call humor.
—Warren Farrell, Women Can’t Hear What Men Don’t Say

Religious Studies professors Paul Nathanson and Katherine Young made similar comparisons in their 2001, three-book series Beyond the Fall of Man, which treats misandry as a form of prejudice and discrimination that has become institutionalized in North American society.

Academic Alice Echols, in her 1989 book Daring To Be Bad: Radical Feminism in America, 1967–1975, argued that radical feminist Valerie Solanas, best known for her attempted murder of Andy Warhol in 1968, displayed an extreme level of misandry compared to other radical feminists of the time in her tract, The SCUM Manifesto. Echols stated,

Solanas’s unabashed misandry—especially her belief in men’s biological inferiority—her endorsement of relationships between ‘independent women,’ and her dismissal of sex as ‘the refuge of the mindless’ contravened the sort of radical feminism which prevailed in most women’s groups across the country.

The text contains aspects of Freudian psychoanalytical theory: the biological accident, the incomplete sex and “penis envy” which became “pussy envy.” Solanas was later diagnosed with paranoid schizophrenia and depression.

Paul Nathanson and Katherine K. Young argued that “ideological feminism” has imposed misandry on culture. Their 2001 book, Spreading Misandry, analyzed “pop cultural artifacts and productions from the 1990s” from movies to greeting cards for what they considered to be pervasive messages of hatred toward men. Legalizing Misandry (2005), the second in the series, gave similar attention to laws in North America.

In 2002, pundit Charlotte Hays wrote “that the anti-male philosophy of radical feminism has filtered into the culture at large is incontestable; indeed, this attitude has become so pervasive that we hardly notice it any longer”.

Sociologist Anthony Synnott argues that the reality of misandry is undeniable when one looks to cultural, academic, and media depictions of men. He states that “misandry is everywhere, culturally acceptable, even normative, largely invisible, taught directly and indirectly by men and women, blind to reality, very damaging and dangerous to men and women in different ways and de-humanizing.” He also criticizes modern scholarship on men as “dehumanizing” and lacking in awareness of statistical reality.