Maria is the wife of George, and great-grandmother of Ninten. According to the beginning of Mother, she and George disappeared in the year 1906. George returned two years later, but Maria did not. She holds an interesting relationship with the game's primary villain, Giegue, as well as the world of Magicant.

She is a major driving force in the plot of Mother; the Eight Melodies are a song she once sung and the bulk of the plot revolves around learning said melody in Ninten's adventure. It is later revealed that the character Queen Mary is the embodiment of Maria's consciousness and that Magicant is a mirage created from it. During the final battle, when using the check command, Maria's consciousness informs Ninten's party that the only thing that may defeat Giegue is to sing her lullaby with all of their heart.