This book will be of particular interest to basic and applied biomedical researchers (students, post-docs or group leaders) with desire to understand the principles of cell-cell communication and mechanisms by which signaling pathways and gene programs control cell proliferation and differentiation, and how this knowledge may come to be applied in the clinic. (springer.com)

This volume is devoted primarily to methods used to study either the behavior of bacteria in response to their environment or methods used to study events that involve signaling pathways that are initiated by events at the cell membrane. (springer.com)

I especially want to thank John S. (Sandy) Parkinson for his contribution of two chapters, his encouragement, his organization of the annual ReceptorFest, and his co-authoring, with Gerald (Jerry) Hazelbauer and Joseph (Joe) Falke the two review articles that provide the best and most-comprehensive discussion of the signaling pathways associated with bacterial chemotaxis. (springer.com)

In this paper we present P systems as a feasible computational modeling tool for cellular signalling pathways that takes into consideration the discrete character of the components of the system and the key role played by membranes in their functioning. (springer.com)

At each step of the signaling cascade, various controlling factors are involved to regulate cellular actions, responding effectively to cues about their changing internal and external environments. (wikipedia.org)

A biochemical cascade, also known as a signaling cascade or signaling pathway, is a series of chemical reactions which are initiated by a stimulus (first messenger) acting on a receptor that is transduced to the cell interior through second messengers (which amplify the initial signal) and ultimately to effector molecules, resulting in a cell response to the initial stimulus. (wikipedia.org)

In a series of 22 cutting-edge chapters forward looking reviews of Smads are provided that cover their discovery, evolution, role in development, mechanism of action and regulation, and how deregulation in Smad signalling contributes to human diseases. (springer.com)

The complex formed produces or releases second messengers that integrate and adapt the signal, amplifying it, by activating molecular targets, which in turn trigger effectors that will lead to the desired cellular response. (wikipedia.org)

We illustrate these cellular models simulating the epidermal growth factor receptor (EGFR) signalling cascade and the FAS-induced apoptosis using a deterministic strategy for the evolution of P systems. (springer.com)

By doing so, they accelerate the G protein's built-in timer, which inactivates the G proteins more quickly, and along with the inactivation of GEFs, this keeps the G protein signal off. (wikipedia.org)

The purpose of the collaboration is to conduct cell signalling research and to encourage development of new drug treatments for global diseases such as cancer, rheumatoid arthritis, and Parkinson's Disease. (wikipedia.org)

Postdoc position - signal transduction & transcription Applications are invited for postdoctoral positions in a newly established research group at the Ludwig Institute for Cancer Research (LICR) in Uppsala, Sweden. (bio.net)

The Division of Signal Transduction Therapy or DSTT is an organization managed by the University of Dundee, the Medical Research Council, and the pharmaceutical companies AstraZeneca, Boehringer Ingelheim, GlaxoSmithKline, Merck Serono, Janssen Pharmaceutica, and Pfizer. (wikipedia.org)

Carrying on the high standards of the much-acclaimed first edition, highly experienced investigators have extensively updated Signal Transduction Protocols with many of the new approaches that have been transforming the field. (springer.com)