This 5-week course, which will start from November 5 to December 14, 2018, is designed for students to explore the hypotheses, logic, principles, and approaches that best exemplify the field of DNA repair. Each week, there will be a one-hour open format discussion of a DNA repair topic led by a faculty member and a two-hour journal club discussion of recent papers that highlight the weekly topic moderated by at least two faculty members. The discussion will occur on Mondays from 9 to 10 a.m. and the journal club will occur on Fridays from 9 to 11 a.m. The course will take place at The University of Texas MD Anderson Cancer Center, Smithville Campus and be video conferenced to the main campus (Houston), with the exception of one week when the campus and video conference sites will be reversed. There will be no specified presenters or pre-prepared slides for the journal club. The course will cover: Nucleotide Excision Repair and Human Disease, DNA Repair in the Context of Chromatin, Meiosis and Homologous Recombination, Antibody Generation as a Model for DNA Repair, and Targeting DNA Repair for Cancer Therapy. Instructors will be faculty in the Epigenetics and Molecular Carcinogenesis Department.