We
measured spontaneous fluctuations of BOLD signal together with whisker
functional stimulation in rat cortex with two slightly different baseline
states: lightly anesthetized with domitor and awakened animals (from domitor)
to explore the connection between power of spontaneous fluctuations and
magnitude of functional response. The same experimental paradigm was applied
during the anesthesia and the waking the rats. Both anesthetized and awakened
rodents showed similar power in the frequency spectrum of spontaneous
fluctuations, but the awakened animals showed higher variability in their
functional responses. Therefore difference in functional response cannot be
explained by the effect of baseline.