From Wikidata Jump to navigation Jump to search vasculitits that is systemic vasculitis realized as blood vessel inflammation and has_symptom asthma along with hay fever, rash and gastrointestinal bleeding.[wikidata.org]

We report the case of a 25-year old man who presented with a history of fever for two months, tingling, numbness, and paraesthesia of the upper limbs and left lower limb, along with diarrhoea for one month and an inability to walk for the past seven days[ncbi.nlm.nih.gov]

Here we report the case of a 10-year-old girl who presented to us with vomiting, abdominal pain, and weightloss, paresthesias of lower extremities and breathlessness as well as a history of asthma, sinusitis and allergic rhinitis.[ncbi.nlm.nih.gov]

Very few reports described myalgia or weakness as the chief complaint. Of these, only a few included muscle biopsy evaluation and none showed convincing evidence of primary myositis.[ncbi.nlm.nih.gov]

We report a case of Churg-Strauss syndrome with presenting symptoms of bilateral lower limb weakness and numbness only. The patient was admitted to an orthopaedic ward for management and a final diagnosis was reached following sural nerve biopsy.[ncbi.nlm.nih.gov]

A 72-year-old Japanese man, who had been previously diagnosed with asthma, presented with weakness of the left leg and purpura on the lower extremities.[ncbi.nlm.nih.gov]

RESULTS: The most common chief complaint was neuropathic limb pain and numbness (100%), followed by extremity weakness (82%). Nine (82%) patients had acute to subacute onset.[ncbi.nlm.nih.gov]

We report a 62-year-old man with mild fever, headache and acute visual loss in his right eye due to anterior ischaemic optic neuropathy (AION), followed a few days later by pain in the legs and left arm associated with numbness and weakness.[ncbi.nlm.nih.gov]

A young male with complaints of cough, dyspnea and hemoptysis was admitted. He was using fluticasone propionate and salmeterol for two years for his asthma.[ncbi.nlm.nih.gov]

If the lungs are involved the following symptoms might be present: cough, shortness of breath, hemoptysis (coughing up blood stained sputum), rales (small clicking, bubbling or rattling sounds in the lung), rhonchi (chest sounds that sound like snoring[cssassociation.org]

Cough and hemoptysis, due to alveolar hemorrhage, may be present. Transient patchy pulmonary infiltrates are common. Neurologic: Neurologic manifestations are very common.[merckmanuals.com]

If the lungs are involved the following symptoms might be present: cough, shortness of breath, hemoptysis (coughing up blood stained sputum), rales (small clicking, bubbling or rattling sounds in the lung), rhonchi (chest sounds that sound like snoring[cssassociation.org]

A 66-year-old Japanese male presented with a history of recurrent abdominalpain. A diagnostic work-up revealed eosinophilia, eosinophilic gastritis, eosinophilic pneumonia, and SIgAD over 1 year of clinical observation.[ncbi.nlm.nih.gov]

The most common symptoms are abdominalpain, diarrhoea and occasionally gastrointestinal bleeding and perforation. We present a case of Churg-Strauss syndrome with small bowel lesions documented by video capsule endoscopy.[ncbi.nlm.nih.gov]

Here we report the case of a 10-year-old girl who presented to us with vomiting, abdominalpain, and weight loss, paresthesias of lower extremities and breathlessness as well as a history of asthma, sinusitis and allergic rhinitis.[ncbi.nlm.nih.gov]

Depending on what organs of the body are affected symptoms can include: Flu-like symptoms including a fever and general feeling of being weak and tired Loss of appetite Weight loss Muscle pain Causes and Risk Factors It is not yet know what causes this[cedars-sinai.edu]

It may be difficult to determine myocardial disease activity status versus tissue damage in CSS with prolonged duration of heartfailure symptoms.[ncbi.nlm.nih.gov]

We report a case of CSS masquerading as a non-ST elevation myocardial infarction with heartfailure.[ncbi.nlm.nih.gov]

Four months later, the patient was hospitalized due to congestive heartfailure with neuropathy of both upper extremities. A diagnosis of eosinophilic myocarditis was made based on the patient's laboratory results and the presence of mural thrombus.[ncbi.nlm.nih.gov]

However, sometimes the other reasons for acute coronary syndrome and heartfailure are found. One of such reasons is hypereosinophilia which can be recognized if number of blood eosinophils exceeds 1500/mm3.[ncbi.nlm.nih.gov]

Here we report a case of CSS presenting with acute myocarditis and heartfailure and review the literature on CSS with cardiac involvement.[ncbi.nlm.nih.gov]

She had conjunctival pallor, gangrene involving all fingertips of the left hand, palpablepurpura on the anterior aspect of the left leg, and 3/5 grade motor weakness of the right wrist joint and left ankle joint on dorsiflexion.[mja.com.au]

A 69-year-old male had an 8-year history of bronchial asthma and chronic sinusitis with hypereosinophilia (35 %), polyneuropathy, and a positive antineutrophil cytoplasmic antibody titer, so he was diagnosed with CSS.[ncbi.nlm.nih.gov]

Pulmonary opacities can be found in 26 - 77% of cases. Pulmonary infiltrates may be transient [2]. Computer Assisted Tomography (CT) findings include areas of consolidation similar to that of chronic pneumonia. Bronchial dilatation and wall thickening may also be seen [2].

In Churg and Strauss' original report, they comment that mild hematuria and albuminuria were commonly present ( 5 ). Three of their 11 patients had azotemia and one died from uremia.[jasn.asnjournals.org]

Cytotoxic drugs are necessary in less than 20% of patients [8]. Cytotoxic agents inhibit cell growth and proliferation of eosinophils. They are reserved for cases that do not respond to corticosteroids. Cyclophosphamide (Cytoxan, Neosar) is the drug most often used.

The cause of Churg-Strauss syndrome is unknown. However, the presence of hypergammaglobulinemia, increased levels of immunoglobulin E (IgE), rheumatoid factor, and anti-neutrophil cytoplasmic antibody, [4] in these patients suggested an allergic autoimmune disorder.

The incidence of Churg-Strauss syndrome in the United States is 1 to 3 cases per 100,000 adults per year [2]. The international incidence of Churg-Strauss syndrome is approximately 2.5 cases per 100,000 adults per year [2].

The vascular inflammation in the disorder results from a prolonged life of eosinophils in these individuals. Although the exact mechanisms involved in Churg-Strauss syndrome have not been identified, it seems to be the secretion eosinophil-activating cytokines [4] by T-lymphocytes that is the stimulating factor.

Churg-Strauss syndrome is a rare, systemic vasculitis that affects small- to medium-sized arteries and veins. It is a multi-system disorder that affects primarily the respiratory system, but can also involve the cardiovascular and renal systems.

The long-term prognosis for Churg-Strauss syndrome is good. Most patients need low dose oral corticosteroids for persistent asthma. Some need continued anti-inflammatory medication for many years after clinical recovery from vasculitis [1] to prevent recurrence.

Most people with Churg-Strauss Syndrome have a history of asthma or other allergy. Usually, a person already has asthma when they develop Churg Strauss syndrome.

The systemic symptoms may follow an allergic reaction by six months or more.Churg-Strauss Syndrome affects all age groups, but children more commonly. Males and females are equally affected.

How is Churg-Strauss syndrome treated?

Churg-Strauss Syndrome is an autoimmune disorder. This means that the body’s immune system mistakenly attacks itself.

Treatment is aimed at slowing the immune response. The most commonly used medication is prednisone, an immunosuppressant. It is given orally, except in severe cases when it is given intravenously. The medication usually works in a few days. But since the symptoms may recur, medication may need to continue long-term.

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