Modeling GroupingRandomly divided into six group: Control group, Model group, Positive drug group and Test drug group

Modeling Period2~4 weeks

Modeling Method1. SD rats (7 day old ) with low birth weight and lactation rats were placed together in the self-made oxygen box sealed. The box is connected with 100% moist pure oxygen, and the oxygen flow rate is controlled at the oxygen concentration of 0.6 to 0.8L/min in the range of 80%±3％. During the period, the oxygen concentration in the oxygen tank was monitored by oxygen meter to ensure the constant oxygen concentration.2. 1 times a day to open the box to replace the oxygen bedding, food, and water exchange and replacement for 5 days, 5 days under high oxygen environment, and then moved to the normal ambient temperature feeding.

Model Evaluation of the Rat Model for Retinopathy of Prematurity (ROP)

Pathological Results of the Rat Model for Retinopathy of Prematurity (ROP)

Cytokines Level of the Rat Model for Retinopathy of Prematurity (ROP)

Statistical Analysis of the Rat Model for Retinopathy of Prematurity (ROP)

SPSS software is used for statistical analysis, measurement data to mean ± standard deviation (x ±ｓ), using t test and single factor analysis of variance for group comparison, P<0.05 indicates there was a significant difference, P<0.01 indicates there are very significant differences.