SLC5A8 has been shown to transport iodide by a passive mechanism (Rodriguez et al., 2002 [PubMed 12107270]) and monocarboxylates and short-chain fatty acids by a sodium-coupled mechanism (Gopal et al., 2004 [PubMed 15322102]). Additionally we are shipping and many more products for this protein.

More Antibodies against SLC5A8 Interaction Partners

Slc5a8 is an obligatory link between dietary fibre and mucosal immune system via the bacterial metabolite butyrate and that this transporter is a conditional tumour suppressor in colon linked to dietary fibre content.

Efficacy of LP or their secreted soluble factors to stimulate SMCT1 expression and function and to counteract the inhibitory effects of TNF-alpha (show TNF Antibodies) on butyrate absorption could have potential therapeutic value.

butyrate and propionate block the generation of dendritic cells from bone marrow stem cells, since Slc5a8 transports butyrate and propionate into cells, and these two bacterial metabolites inhibit histone deacetylases

In conventional mice with normal bacterial colonization of the intestinal tract, GPR109A and SLC5A8 are expressed on the apical membrane of epithelial cells lining the ileum and colon.

CDX1 (show CDX1 Antibodies) and CDX2 (show CDX2 Antibodies) bind the promoter region of SLC5A8 and up-regulate its expression in cultured cells and in colonic epithelium.

slc5a8 is expressed abundantly in the kidney and plays a role in the active reabsorption of lactate

SMCT functions not only as a Na+-coupled transporter for short-chain fatty acids and lactate but also as a Na+-coupled transporter for the water-soluble vitamin nicotinic acid.

The shared epigenetic inactivation of mSLC5A8 in mouse gliomas indicates an additional degree of commonality in the origin and/or pathway to tumorigenesis between primary human tumors and these mouse models of gliomas.

SLC5A8 nuclear translocation and loss of expression are associated with poor outcome in pancreatic ductal adenocarcinoma.

SLC5A8 has a role in prostate cancer risk and aggressiveness

SLC5A8 is highly methylated in African American colon adenomas

Efficacy of LP or their secreted soluble factors to stimulate SMCT1 expression and function and to counteract the inhibitory effects of TNF-alpha (show TNF Antibodies) on butyrate absorption could have potential therapeutic value.