Background

Mr. William R. Ringo, Jr., also known as Bill, serves as a Senior Advisor of Barclays Capital PLC. Mr. Ringo has been a Strategic Advisor at Sofinnova Ventures, Inc. since 2010. He joined Sofinnova in January 2007 and specializes in life sciences. He serves as an Advisor of InCube Labs, LLC. Mr. Ringo is a Venture Partner at InCube Ventures, LLC. He serves as an Advisor and Industry Expert of Pearl Street Venture Funds. He has been a Health Care Consultant at Barnard ... Life Sciences, which he founded in January 2001. Mr. Ringo is also a Founding Member of Pearl Street Venture Funds, which was founded in 2000. Previously, he served as an Executive In Residence at Warburg Pincus and Sofinnova Ventures. Mr. Ringo served as the Senior Vice President of Strategy and Business Development at Pfizer Inc. from April 2008 to 2010 and served as its Senior Vice President of Business Development Strategy and Innovation until April 30, 2010. He served as the Chief Executive Officer and President at Abgenix Inc. from August 30, 2004 to April 2006. At Abgenix, he focused on product by strengthening the senior management team and enhancing an existing partnership with Amgen, which purchased Abgenix in 2006. Mr. Ringo oversaw clinical progress with Abgenix's pipeline of antibody therapies and brokered the Amgen acquisition. He served as an Interim Chief Executive Officer and President at InterMune, Inc. from June 30, 2003 to September 25, 2003. From 1973 to March 2001, Mr. Ringo served at Eli Lilly and Company in Executive leadership roles for 30 years as the President of the Oncology and Critical Care Products Unit from 1998 to March 2001 as well as the President of Internal Medicine Products from 1998 to March 2001. Mr. Ringo has a global understanding of the pharmaceutical, biotech, and medical device industry segments as reflected in the number of leadership positions and held at Lilly. He served as a Vice President of Sales and Marketing for Cardiac Pacemakers, Director of Business Planning for Lilly's Medical Devices and Diagnostics Division and President and General Manager of Eli Lilly Canada, Inc. since 1988. He returned to Indianapolis in 1991 as an Executive Director of Market Research. Mr. Ringo served as a Vice President of Marketing for United States Pharmaceutical Operations since 1993 and Vice President of Sales and Marketing since 1994. From 1995 to 1997, he served as the President of the Infectious Disease Business Unit. He has been the Chairman of Assembly Biosciences, Inc. since February 2015. He has been the Chairman and Director of Sangamo BioSciences Inc. since April 16, 2010. He has been a Director of Assembly Biosciences, Inc. since July 11, 2014 and Dermira, Inc. since July 2014. He serves as a Member of Scientific Board of Advisors for Burrell Ventures and a Trustee at the Heart Hospital of Indiana. He serves as a Director of BioCrossroads. He has been a Director of Immune Design Corp. since March 2014, Five Prime Therapeutics, Inc. since October 2, 2014 and Mirati Therapeutics, Inc. since March 20, 2014. Mr. Ringo serves as a Member of Board of Advisors at InCube Ventures, LLC. He served as a Director of Ascendis Pharma A/S. Mr. Ringo serves on the Board of a number of early-stage life science companies including Suros Surgical Systems, Inc. Mr. Ringo serves as a Member of Community Hospitals of Indianapolis. Mr. Ringo served as the Chairman of Community Health Network. He served as an Executive Chairman of the Board of InterMune, Inc. from May 2003 to May 13, 2008 and Vice Chairman of Inspire Pharmaceuticals Inc. from March 2004 to June 2008. He serves as a Board Member for Ascendis Medical Technology. Mr. Ringo served as a Director of Portola Pharmaceuticals, Inc. since December 13, 2006, InterMune, Inc. from June 2002 to May 13, 2008, Allos Therapeutics, Inc. from January 8, 2007 to June 24, 2008 and Inspire Pharmaceuticals Inc. from June 2003 to June 2008. He served as a Director of Onyx Pharmaceuticals, Inc. from February 3, 2011 to 2013. He served as a Director of Marcadia Biotech, Inc. He served as a Director of Abgenix Inc. since August 30, 2004, Xcel Pharmaceuticals Inc., since July 2001, Praecis Pharmaceuticals Inc. from March 2001 to August 2004, La Jolla Pharmaceutical Co. since May 2001, and Texas Biotechnology Corporation from October 2001 to August 2004. He served as a Director of Encysive Pharmaceuticals Inc. since January 2001. He served as a Director of Alvine Pharmaceuticals, Inc. Mr. Ringo was awarded the Bronze Star for his service in Vietnam. Mr. Ringo also served as a Captain in the United States Army, Military Intelligence. Mr. Ringo has over 38 years of marketing and product commercialization experience as a pharmaceutical and biotechnology company executive. He has more than four decades of biopharmaceutical experience in a variety of leadership and advisory roles. He received an M.B.A. degree in 1973 and a B.S. degree in Management and Business Administration in 1967 from the University of Dayton.

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