The investigators here propose to perform a prospective randomized intervention trial in post-menopausal women to investigate the endocrine network, which contributes to the changes in skeletal muscle mass during weight loss.

multimodal lifestyle intervention will be performed to reduce body weight

Placebo Comparator: placebo

placebo

Behavioral: placebo

no intervention, only follow up

Eligibility

Ages Eligible for Study:

40 Years to 80 Years (Adult, Senior)

Genders Eligible for Study:

Female

Accepts Healthy Volunteers:

Yes

Criteria

Inclusion Criteria:

BMI > 27 kg/m2 (adults)

Exclusion Criteria:

weight loss of more than 5kg in the last 2 months

patients with:

severe heart failure

impaired hepatic or renal function

severe anaemia

disturbed coagulation

infection, malabsorption

severe hypertension

myopathia

any other uncontrolled endocrine disorder

changes of smoking habits or diets within the last 3 months prior to study inclusion

Contacts and Locations

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study.
To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below.
For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01105143