Abstract

We report a 32-year-old woman (1-gravid, 1-para) with a vesicular lesion in her uterus
that was pointed out on ultrasound at 8 weeks' gestation. Amniocentesis at 15 weeks'
gestation showed a normal female karyotype, 46XX. As the pregnancy advanced, the mole-like
lesion became relatively reduced. Throughout gestation, the maternal human chorionic
gonadotropin level was normal, but the serum alpha fetoprotein level rose as her pregnancy
progressed. Her fetus did not exhibit any remarkable anomalies. The patient visited
our hospital complaining of a diminished feeling of fetal movements at 36 weeks 5
days' gestation, and intrauterine fetal death (IUFD) was confirmed. She delivered
a 2336-g female without any definite anomalies. A pathological examination led to
a diagnosis of placental mesenchymal dysplasia, and androgenetic/biparental mosaicism
in the placenta was identified using p57kip2 immunohistochemical staining. And it also revealed that the rupture of the cirsoid
chorionic vessels had led to IUFD.