German Research Foundation funds a three-year joint project of the Mainz University Medical Center and the University of Münster to the tune of about EUR 460,000

The work group "Pain – Autonomic Nervous System" headed by Professor Dr. Frank Birklein of the Department of Neurology at the Mainz University Medical Center and the collaborating research team of bioanalyst Professor Dr. Simone König of the University of Münster have been granted funding of approximately EUR 460,000 by the German Research Foundation (DFG) to conduct research into the complex regional pain syndrome (CRPS).

This syndrome is a posttraumatic pain disorder that some 5 percent of patients develop after an injury, such as a bone fracture. These patients exhibit exacerbated inflammatory reactions in the affected limbs, the symptoms of which include hyperthermia, edema, excessive sweating, and pain on movement. The aim of this three-year joint research project is to study the inflammatory processes in the tissue and thus develop a rapid, targeted, and individually tailored treatment for CRPS.

If, several weeks after suffering an injury or an accident or undergoing surgery to arms or legs, the patient continues to have severe and persistent pain coupled with vegetative symptoms in the affected extremities for which there is no apparent cause, it is often the case that this individual is suffering from what is known as the complex regional pain syndrome (CPRS, also called Sudeck's atrophy).

In such cases, the pain does not subside as expected after a relatively minor injury such as bruising or a sprained ankle or following surgery. Instead, the pain becomes more severe and other symptoms develop, such as swelling, temperature changes of the skin, increased hair and nail growth, and restriction of movement and functions.

If there are nerves that were damaged by the original injury, the condition is called complex regional pain syndrome type II (CRPS II). It is estimated that about 5,000 to 10,000 patients in Germany are affected annually, among them significantly more women than men. Most patients are in the age range of 40 to 60 years.

The mechanisms underlying this disorder are still not understood so treatment is fairly non-specific. The diagnosis can often only be made by the process of elimination. On the other hand, if CRPS is detected at an early stage it can be cured. The earlier treatment begins, the better the chances of recovery. The illness is currently treated by a multimodal treatment approach, which usually involves a combination of drug treatment, physiotherapy, and psychotherapy.

During the research project, the researchers at the Medical Center of Johannes Gutenberg University Mainz will be studying how and why the inflammatory processes occur in the tissue in CRPS and in particular why they do not disappear when the wound has physically healed. The researchers of Birklein's work group in the Department of Neurology at the Mainz University Medical Center along with their national and international cooperation partners around the world have published most of the medical articles on the topic of CRPS so far and have already made important progress towards describing and detecting the inflammation associated with CRPS.

"If we want to be able to develop targeted individual treatments, we first need to find the answer to the question of 'Why?'. We hope that we will obtain the necessary information in this research project," said Professor Dr. Frank Birklein.

About the University Medical Center of Johannes Gutenberg University Mainz The University Medical Center of Johannes Gutenberg University Mainz is the only facility of its kind in Rhineland-Palatinate. It consists of more than 60 clinics, institutes, and departments. Research and teaching are inextricably linked with medical treatment. Approximately 3,500 students of medicine and dentistry are trained in Mainz on a continuous basis. More information can be found at http://www.unimedizin-mainz.de/index.php?L=1

Die letzten 5 Focus-News des innovations-reports im Überblick:

For the first time, a team of researchers at the Max-Planck Institute (MPI) for Polymer Research in Mainz, Germany, has succeeded in making an integrated circuit (IC) from just a monolayer of a semiconducting polymer via a bottom-up, self-assembly approach.

In the self-assembly process, the semiconducting polymer arranges itself into an ordered monolayer in a transistor. The transistors are binary switches used...

For photographers and scientists, lenses are lifesavers. They reflect and refract light, making possible the imaging systems that drive discovery through the microscope and preserve history through cameras.

But today's glass-based lenses are bulky and resist miniaturization. Next-generation technologies, such as ultrathin cameras or tiny microscopes, require...

Scientists from the University of Zurich have succeeded for the first time in tracking individual stem cells and their neuronal progeny over months within the intact adult brain. This study sheds light on how new neurons are produced throughout life.

The generation of new nerve cells was once thought to taper off at the end of embryonic development. However, recent research has shown that the adult brain...