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You could stay downtown, but there is not a lot to do there except visit & walk around Lake Eola. Perhaps a better area would be anything on International Drive. This way, you would be able to use the I Ride trolley http://www.iridetrolley.com/index.html Take a look at the map and see all the things you could do: http://www.iridetrolley.com/pdf/marker-map.pdf Look at the accommodations listing on the map for a huge choice of hotels.

Agree with I-Drive area (Check out Pointe Orlando) , also consider a Universal studios hotel and you can walk to CityWalk (restaurants, bars, clubs, movie theater). Or closer to disney there is Lake Buena Vista where you can walk to Downtown Disney (similar to CityWalk). I can recommend the Buena Vista Palace: http://www.buenavistapalace.com/ . Downtown there is the Bohemian hotel and Embassey Suites.