Phys.org news tagged with:mesenchymal cellshttp://phys.org/
en-usPhys.org internet news portal provides the latest news on science including: Physics, Nanotechnology, Life Sciences, Space Science, Earth Science, Environment, Health and Medicine.Engineer develops model to predict behavior of cell clustersAn engineer at Washington University in St. Louis discovered a model in which the mechanics of the cells' environment can predict their movement, a finding that ultimately could mean confining cell transition in tumors and potentially making cancer "a substantially less deadly disease," said the lead researcher.http://phys.org/news/2016-11-behavior-cell-clusters.html
General Physics Wed, 16 Nov 2016 06:54:10 ESTnews398501643Research points to ways to improve the therapeutic potential of stem cellsStem cells hold great promise for transforming medical care related to a diverse range of conditions, but the cells often lose some of their therapeutic potential when scientists try to grow and expand them in the laboratory. A new study, however, provides insights on the cellular mechanisms that might be targeted to help certain stem cells—called human mesenchymal stem cells (hMSCs)—maintain properties needed to make them clinically useful.http://phys.org/news/2016-10-ways-therapeutic-potential-stem-cells.html
Cell & Microbiology Tue, 11 Oct 2016 13:03:25 ESTnews395409798Stem cell research could lead to treatment breakthroughsScientists have discovered a new way to replicate the regenerative power of stem cells in the lab, which could lead to powerful treatments for injuries and diseases.http://phys.org/news/2016-09-stem-cell-treatment-breakthroughs.html
Bio & Medicine Wed, 21 Sep 2016 09:10:02 ESTnews393667497Nanofiber scaffolds demonstrate new features in the behaviour of stem and cancer cellsNovel scaffolds are shown enabling cells to behave in a different but controlled way in vitro due to the presence of aligned, self-assembled ceramic nanofibers of an ultra-high anisotropy ratio augmented into graphene shells.http://phys.org/news/2016-08-nanofiber-scaffolds-features-behaviour-stem.html
Bio & Medicine Tue, 23 Aug 2016 07:41:58 ESTnews391156908Team develops bio-mimicry method for preparing and labeling stem cellsResearchers led by Carnegie Mellon University Professor of Biological Sciences Chien Ho have developed a new method for preparing mesenchymal stem cells (MSCs) that not only leads to the production of more native stem cells, but also labels them with a FDA approved iron-oxide nanoparticle (Ferumoxytol). The technology could allow researchers to track the cells in vivo using magnetic resonance imaging (MRI) during preclinical and clinical trials. The findings are published by Scientific Reports.http://phys.org/news/2016-05-team-bio-mimicry-method-stem-cells.html
Cell & Microbiology Wed, 18 May 2016 05:00:03 ESTnews382760789Researchers track neural stem cells by coloring chicken eggs from the insideAn overwhelming number of researchers still struggle within the black hole of the effectiveness and safety of stem cell therapy for neurological diseases. While the complexity of understanding how neurons grow, connect and function has long been studied, it remains a mystery, one that graduate student Forrest Goodfellow in the University of Georgia Regenerative Bioscience Center is helping unravel.http://phys.org/news/2016-03-track-neural-stem-cells-chicken.html
Cell & Microbiology Mon, 21 Mar 2016 07:20:11 ESTnews377763600Physical parameters matter in terms of cancer cells' metastatic abilityThe micro-environment surrounding cancer cells is just as important as genes in regulating tumour progression. Scientists have therefore examined the biophysical and biochemical cues occurring in the vicinity of cancer cells. This represents a departure from the traditional measurement of secreted molecules, called biomarkers. The latest research in this field, recently published in EPJ Plus, found that the presence of a substance called Epidermal Growth Factor (EGF) promotes the motility of elongated mesenchymal tumour cells, which migrate depending on their adhesive properties by climbing along collagen fibres, in contrast to rounded tumour cells, which migrate in an adhesion-independent manner. These findings stem from the work of Dongil Geum and BJ Kim in the Wu biofluifics lab at Cornell University, Ithaca, New York, USA.http://phys.org/news/2016-02-physical-parameters-terms-cancer-cells.html
General Physics Mon, 01 Feb 2016 10:21:44 ESTnews373544497New hydrogel gives clues to mechanism behind stress-stiffening-mediated mesenchymal stem cell fate(Phys.org)—Several properties of the extracellular matrix affect cellular interaction, including stem cell differentiation. Some of these are physical properties, such as topography and matrix stiffness. In an effort to investigate these physical properties, Rajat K. Das, Veronika Gocheva, Roel Hammink, Omar F. Zouani, and Alan E. Rowan from Radbound University in The Netherlands, and the company Histide in Switzerland designed a model 3D hydrogel polymer system that demonstrates how stress-stiffening in the extracellular matrix causes human mesenchymal stem cells to favor osteogenesis over adipogenesis. Using their new model system, they determined that the expression of DCAMKL1, a microtubule associated protein, is decreasing when stress-stiffness is higher, demonstrating a novel pathway in which microtubule dynamics affects cell fate. Their work appears in Nature Materials.http://phys.org/news/2015-12-hydrogel-clues-mechanism-stress-stiffening-mediated-mesenchymal.html
Materials Science Thu, 17 Dec 2015 09:20:03 ESTnews369557875Development of gold nanoparticles that control osteogenic differentiation of stem cellsTissue Regeneration Materials Unit at MANA, NIMS successfully developed gold nanoparticles that have functional surfaces and act on osteogenic differentiation of stem cells.http://phys.org/news/2015-05-gold-nanoparticles-osteogenic-differentiation-stem.html
Bio & Medicine Thu, 21 May 2015 07:08:55 ESTnews351410923Crosstalk between genetically abnormal epithelial cells and normal support cells drives tumor formationGenetically abnormal epithelial cells can interact with genetically normal support cells to help each other proliferate and to drive tumor formation, shows a study by A*STAR researchers using a fruit fly model. Inhibition of the signals that pass between these cells has the potential to block the growth and development of solid tumors.http://phys.org/news/2014-12-crosstalk-genetically-abnormal-epithelial-cells.html
Cell & Microbiology Wed, 03 Dec 2014 07:50:01 ESTnews336814477New technique allows scientists to find rare stem cells within bone marrowDeep within the bone marrow resides a type of cells known as mesenchymal stem cells (MSCs). These immature cells can differentiate into cells that produce bone, cartilage, fat, or muscle—a trait that scientists have tried to exploit for tissue repair.http://phys.org/news/2014-10-technique-scientists-rare-stem-cells.html
Biotechnology Mon, 06 Oct 2014 16:49:00 ESTnews331832931Microchip reveals how tumor cells transition to invasionUsing a microengineered device that acts as an obstacle course for cells, researchers have shed new light on a cellular metamorphosis thought to play a role in tumor cell invasion throughout the body.http://phys.org/news/2014-08-microchip-reveals-tumor-cells-transition.html
Cell & Microbiology Sun, 17 Aug 2014 13:00:06 ESTnews327472467Veterinary surgeons use feline adult stem cells in kidney transplantVeterinary surgeons in the University of Georgia Veterinary Teaching Hospital successfully performed a kidney transplant in a domestic cat and used stem cells harvested from the patient to optimize the cat's acceptance of the new kidney.http://phys.org/news/2014-06-veterinary-surgeons-feline-adult-stem.html
Plants & Animals Wed, 18 Jun 2014 06:23:23 ESTnews322290414Researchers find human menstrual blood-derived cells 'feed' embryonic stem cellsResearchers investigating the use of human menstrual blood-derived mesenchymal cells (MBMCs) as culture 'feeder layers' found that MBMCs can replace animal-derived feeder systems in human embryonic stem cell culture systems and support their undifferentiated growth, while helping the cells proliferate and survive. For medical transplantation, human embryonic stem cells (hESCs) may need to remain "undifferentiated" and the experimenter's technique preserves the undifferentiated nature of hESCs destined for transplantation and also prevents potential animal cell contamination.http://phys.org/news/2014-05-human-menstrual-blood-derived-cells-embryonic.html
Cell & Microbiology Wed, 28 May 2014 12:21:39 ESTnews320498484Researchers find stem cells remember prior substrates(Phys.org) —A team of researchers working at the University of Colorado has found that human stem cells appear to remember the physical nature of the structure they were grown on, after being moved to a different substrate. In their paper published in the journal Nature Materials, the researchers describe how they grew human stem cells on different substrates. In so doing, they discovered that the stem cells continued to express certain proteins related to a substrate even after its hardness was changed.http://phys.org/news/2014-03-stem-cells-prior-substrates.html
Cell & Microbiology Mon, 17 Mar 2014 08:52:54 ESTnews314265162New shrinking gel steers tooth tissue formationA bit of pressure from a new shrinking, sponge-like gel is all it takes to turn transplanted unspecialized cells into cells that lay down minerals and begin to form teeth.http://phys.org/news/2014-03-gel-tooth-tissue-formation.html
Materials Science Wed, 05 Mar 2014 12:22:04 ESTnews313244490Signal gradients in 3-D guide stem cell behaviorScientists know that physical and biochemical signals can guide cells to make, for example, muscle, blood vessels or bone. But the exact recipes to produce the desired tissues have proved elusive.http://phys.org/news/2013-09-gradients-d-stem-cell-behavior.html
Biochemistry Wed, 18 Sep 2013 09:23:49 ESTnews298714991Discovery alters understanding of long-distance intercellular communication(Phys.org) —In a finding likely to fundamentally reshape biologists' understanding of how vertebrate cells communicate, researchers at the Stanford University School of Medicine and the UC-San Francisco have discovered a new type of cellular structure that directly delivers and receives payloads of signaling molecules between distant neighbors in a developing embryo.http://phys.org/news/2013-04-discovery-long-distance-intercellular.html
Cell & Microbiology Mon, 29 Apr 2013 07:43:31 ESTnews286440201Rigid growth matrix: A key to success of cardiac tissue engineeringA new study by researchers at UCLA suggests that the elasticity of the physical matrix used for growing heart muscle cells outside of the body may be critical to the success of cardiac tissue engineering. The results were published in the journal Science and Technology of Advanced Materials this week.http://phys.org/news/2013-04-rigid-growth-matrix-key-success.html
Materials Science Mon, 15 Apr 2013 07:30:03 ESTnews285229121Researchers show stem cell fate depends on 'grip'The field of regenerative medicine holds great promise, propelled by greater understanding of how stem cells differentiate themselves into many of the body's different cell types. But clinical applications in the field have been slow to materialize, partially owing to difficulties in replicating the conditions these cells naturally experience.http://phys.org/news/2013-03-stem-cell-fate.html
Materials Science Thu, 28 Mar 2013 12:34:35 ESTnews283692868Stem cells could heal equine tendon injuriesTendon injuries affect athletic horses at all levels. Researchers from the University of Connecticut are studying the use of stem cells in treating equine tendon injuries. Their findings were published Oct. 16 in the Journal of Animal Science Papers in Press.http://phys.org/news/2012-11-stem-cells-equine-tendon-injuries.html
Plants & Animals Thu, 01 Nov 2012 14:32:17 ESTnews270999123Exercise boosts health by influencing stem cells to become bone, not fat, researchers findMcMaster researchers have found one more reason to exercise: working out triggers influential stem cells to become bone instead of fat, improving overall health by boosting the body's capacity to make blood.http://phys.org/news/2011-09-boosts-health-stem-cells-bone.html
Cell & Microbiology Thu, 01 Sep 2011 11:13:14 ESTnews234094358Protein and microRNA block cellular transition vital to metastasisLike a bounty hunter returning escapees to custody, a cancer-fighting gene converts organ cells that change into highly mobile stem cells back to their original, stationary state, researchers report online at Nature Cell Biology.http://phys.org/news/2011-02-protein-microrna-block-cellular-transition.html
Cell & Microbiology Fri, 25 Feb 2011 16:21:10 ESTnews217873232Engineered cells could usher in programmable cell therapiesIn work that could jumpstart the promising field of cell therapy, in which cells are transplanted into the body to treat a variety of diseases and tissue defects, researchers at Brigham and Women's Hospital (BWH) have engineered cells that could solve one of the key challenges associated with the procedure: control of the cells and their microenvironment following transplantation.http://phys.org/news/2011-02-cells-usher-programmable-cell-therapies.html
Biotechnology Wed, 02 Feb 2011 08:59:37 ESTnews215859530Cells 'feel' the difference between stiff or soft and thick or thin matrixCultured mesenchymal stem cells can "feel" at least several microns below the surface of an artificial microfilm matrix, gauging the elasticity of the extracellular bedding that is a crucial variable in determining their fate, researchers reported today at the American Society for Cell Biology's 50th Annual Meeting in Philadelphia.http://phys.org/news/2010-12-cells-difference-stiff-soft-thick.html
Cell & Microbiology Mon, 13 Dec 2010 10:22:42 ESTnews211458151Tests show bright future for gadonanotubes in stem cell tracking(PhysOrg.com) -- Gadonanotubes (GNTs) developed at Rice University are beginning to show positive results in a study funded by a federal stimulus grant through the National Institutes of Health (NIH) last year.http://phys.org/news/2010-11-bright-future-gadonanotubes-stem-cell.html
Bio & Medicine Fri, 12 Nov 2010 15:05:24 ESTnews208796667Researchers engineer adult stem cells that do not age(PhysOrg.com) -- Biomedical researchers at the University at Buffalo have engineered adult stem cells that scientists can grow continuously in culture, a discovery that could speed development of cost-effective treatments for diseases including heart disease, diabetes, immune disorders and neurodegenerative diseases.http://phys.org/news/2010-09-adult-stem-cells-age.html
Biotechnology Wed, 22 Sep 2010 15:55:59 ESTnews204389634Using bone marrow stem cells to treat critically ill patients on verge of respiratory failureResearchers are reporting this week new study results they say provide further evidence of the therapeutic potential of stem cells derived from bone marrow for patients suffering from acute lung injury, one of the most common causes of respiratory failure in intensive care units.http://phys.org/news/2010-08-bone-marrow-stem-cells-critically.html
Biochemistry Wed, 11 Aug 2010 15:25:32 ESTnews200759117