regression was
used to compare the likelihood of readmission within 30 and 90 days.

The analysis included 38,664 patient discharges with 53 percent
(20,577) receiving LMWH and 47 percent (18,087) receiving UFH. Among
patients who received LMWH, 97.3 percent (20,021) of them received Lovenox,
with the remaining 2.7% receiving other LMWHs. The two groups were similar
in clinical and demographic characteristics. The average length of hospital
stay for the UFH group was 1.1 days longer (5.7 days vs. 4.6) days. After
adjustment for covariates, the average total direct hospital costs were
$3,618 for UFH and $3,068 for LMWH (difference $550, P<0.0001). Lovenox was
associated with reduced cost in most categories although anticoagulation
therapy costs were higher for LMWH ($242 versus $41 for UFH, P<0.0001).
LMWH was associated with lower rates of VTE-related readmission at both 30
days (11.2% vs 12.1%; odds ratio [OR] 0.89, 95% confidence interval [CI]
0.84-0.96; P=0.001) and 90 days (13.1% vs 13.8%; OR 0.91, 95% CI 0.85-0.96;
P<0.001).

Dr. Geno Merli, Director at the Jefferson Center for Vascular Disease,
Jefferson Medical College, Philadelphia, PA and a lead investigator of the
analysis said, "What the results showed is that despite higher drug-related
costs for Lovenox, the total direct medical costs for the treatment of VTE
is reduced when compared to using UFH. For every 1,000 patients treated for
documented DVT, the use of Lovenox may save approximately half a million
dollars."

About Premier's Perspective(TM) Database

Premier's Perspective(TM) database is the most comprehensive clinical,
financial and operational comparative database in the U.S. and contains
information from hundreds of hospitals and millions of discharges,
providing means by which hospitals can benchmark their efforts against
other hospitals in an effort to improve quality and reduce costs.

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