The Cold Spring Harbor Laboratory will be hosting a conference on the Ubiquitin Proteasome System (UPS) and associated Diseases April 23rd-27th. LifeSensors will be presenting on our most recent devel...

Parkinson's Disease: Biomarkers for Early Discovery

LifeSensors to Sponsor Discovery on Target

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LifeSensors to Sponsor Discovery on TargetTo help further scientific advancement in the field of ubiquitin, LifeSensors has partnered with CHI to assist with their Discovery on Target conference this ...

Protein Profiles: CHIP

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CHIPCHIP is an E3 that coordinates with Ataxin3 to mark misfolded chaperone proteins for UPS degradation. Deficiencies within this pathway are associated with rare disease, such as Spinocerebellar Ata...

Protein Profiles: Nedd4

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Nedd4Nedd4 is an inner membrane bound HECT E3 that
promotes endocytosis of sodium channels marked for degradation at FGFR1
receptors, with K63 linked ubiquitin selectivity. Nedd4 has also been shown...

Protein Profiles: UCHL1

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UCHL1The protein encoded by UCHL1 (Ubiquitin C-Terminal Hydrolase L1) is a thiol
protease belonging to the C12 family of peptidases that hydrolyze peptide bonds
at the C-terminal glycine of ubiquiti...

Protein Profiles: α-Synuclein

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α-SynucleinPDB ID: 1XQ8α-Synuclein is mainly found in the brain and is present at
the presynaptic terminal of neurons. Although its function in a healthy brain
is currently unknown, α-Synuclein is b...

Protein Profiles: PINK1

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PINK1PDB ID: 50ATPTEN induced putative kinase 1 (PINK1) is important in the
role of mitophagy, once it accumulates on the outer membrane of a damaged
mitochondria, it summons PARKIN to begin the pro...

Protein Profiles: β-Amyloid

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β-AmyloidPDB ID: 38KCAmyloid precursor proteins (APP), present in the fatty
membrane of neuronal cells, undergo a series of enzymatic cleavages to create
smaller proteins known as β-Amyloid. Sometim...