St. Louis (City) County, Mo., funds by Health and Human Services, Department of

Note: For some programs where states do not report where money will be distributed across the state, we do not have the allocation for individual counties. Those programs include: Medicaid, unemployment benefits and food stamps. Those amounts are included in the totals for where the state agency receiving that money is located.

Amount refers to both the amount of stimulus funding going toward the project and the face value of the loan.

Recipient

Amount

Description

Federal Dept./Agency

Date

WASHINGTON UNIVERSITY, THE

$14,273,023

National Center for Research Resources, Recovery Act Construction Support Washington University School of Medicine has been at the forefront of genome science since the inception of the field. There is currently over $81 million in annual grant funding to support major sequencing and genome analysis s projects at The Genome Cente... Show more

Trans-NIH Recovery Act Research Support The project proposed additional TCGA sequencing and analysis. We propose an approach that combines the power of four distinct sequencing methods to discover somatic events in human cancer genomes, and that should scale linearly depending on the funds ava

ARRA - Community Services Block Grant The ARRA funding allowed the DSS to serve a population who are ineligible under regular CSBG funding. The funds allowed for start-up costs for some new programs and expansion of existing programs. The DSS, though the community action agencies will conti

Trans-NIH Recovery Act Research Support In summary, this proposal focuses on two of the five themes outlined in the RFA-OD-10-005: 'Applying Genomics and Other High Throughput Technologies' and 'Translating Basic Science Discoveries into New and Better Treatments' and is ready for immediate imp

Trans-NIH Recovery Act Research Support The prevalence of childhood overweight (CO) has tripled in recent decades, and related health care costs have quadrupled. While lifestyle interventions for CO have produced promising short-term results, a substantial percentage of children regain all or m

Trans-NIH Recovery Act Research Support WASHINGTON UNIVERSITY CER MENTORED CAREER DEVELOPMENT AWARD KM1 The PI wishes to use the existing abstract as reported in the NIH reporter as her Award Description for ARRA reporting purposes.

Trans-NIH Recovery Act Research Support This application responds to the NHLBI 'Grand Opportunities' RC2 topic, 'Large-scale DNA Sequencing and Molecular Profiling of Well-Phenotyped NHLBI Cohorts.' We will use whole genome resequencing to identify genetic changes relevant for the pathogenesis

Trans-NIH Recovery Act Research Support This project aims to define the roles of inositol signaling reactions in the pathogenesis of disease. We will study the role of inositol 1,3,4-5/6-kinase in fat cell differentiation. This enzyme catalyzes the first step in formation of inositol hexakispho

Trans-NIH Recovery Act Research Support The ultimate goal of this 2 year NIH-NHLBI RC2 GO Grant (RFA-OD-09-004), Comparative Effectiveness, is to develop a websystem that facilitates Community Based Participatory Research (CBPR) to identify populations underrepresented in research. This effort

Trans-NIH Recovery Act Research Support Hypertension (HTN), a disease that affects over 65 million Americans, is one of the most common chronic diseases in the world. Hypertensive heart disease (HHD) phenotypes, including left ventricular (LV) hypertrophy (LVH), LV diastolic dysfunction (LVDD),

Trans-NIH Recovery Act Research Support Influenza viruses are among the most frequent causes of severe respiratory illness, and new influenza viruses continue to cause re-emerging and newly emerging disease that resists established vaccines. Since existing therapy is unsatisfactory, we develope

Trans-NIH Recovery Act Research Support This proposal is from Dr. Linda Sandell, a cartilage biologist in the Department of Orthopaedic Surgery and Dr. Jim Cheverud, a population geneticist in the Department of Anatomy and Neurobiology. We propose to identify genetically defined mouse models of

ARRA Health Center Integrated Services Development Initiative[g1] ARRA HRSA-09-244 Capital Improvement Program. This project includes three components: a new parking lot; adding 4,500 sq. ft. to the north county site and purchasing equipment.CIP funding granted to PHC will allow the construction of a additional parking fo... Show more

Trans-NIH Recovery Act Research Support NEW OBSERVATIONAL DATA ANALYSIS METHODS FOR COMPARATIVE EFFECTIVENESS RESEARCH Comparative effectiveness research (CER) is designed to identify healthcare interventions having the best patient outcomes to direct patients to receive the best treatment and

Trans-NIH Recovery Act Research Support Nanomedicine approaches to atherosclerotic disease could have significant impact on the practice and outcomes of cardiovascular medicine. With recent concerns about the use of gadolinium and its relationship to Nephrogenic Systemic Fibrosis (NSF), alterna

Trans-NIH Recovery Act Research Support This proposal seeks to advance T1 and T2 translational research at the Washington University Institute of Clinical and Translational Sciences (ICTS) by establishing a new multidisciplinary Lifestyle Intervention Research Core (LIRC) to assess lifestyle (i

Trans-NIH Recovery Act Research Support This grant proposal is in response to RFA-OD-09-005, 'Recovery Act limited Competition: Supporting New Faculty Recruitment to Enhance Research Resources through Biomedical Research Core Centers' and is entitled 'Translational Neuroscientist and the Hope C

ARRA Health Center Integrated Services Development Initiative[g1] The overall purpose of the Capital Improvement Program (CIP) funding was to address the improvement of provider patient flow, increase provider productivity, and reduce re-scheduling of patient appointments due to the breakdown of clininical equipment. The... Show more

Trans-NIH Recovery Act Research Support The current epidemic of Methicillin Resistant Staphylococcus aureus infection is a grand opportunity to apply new genetic methods to understanding this disease. There are multiple outcomes from MRSA infection, ranging from curable localized infection to d

Trans-NIH Recovery Act Research Support The Coordinating Center of the Ocular Hypertension Treatment Study (OHTS) has 3 specific aims to be completed within the 24 month funding period of the Recovery Act as follows: a. OHTS is the only randomized trial to compare the safety and efficacy of two

Trans-NIH Recovery Act Research Support Heart failure affects more than 5 million Americans, and strikes over 500,000 new patients each year. Due in the majority of instances to dilated or ischemic cardiomyopathies, heart failure is a classic 'complex disease', i.e. it is multi-factorial and ha

Trans-NIH Recovery Act Research Support The Advanced Technology QA Consortium (ATC), through the Image-Guided Therapy Center (ITC) at Washington University, has developed an advanced medical informatics infrastructure that enables institutions to submit, and QA Centers to receive, share, and a

Trans-NIH Recovery Act Research Support Project is on No Cost Extension through 6/30/12. A number of hormones and membrane proteins bear carbohydrate chains that contain unique sugars with unusual modifying groups such as sulfate. The attachment of these unique sugars is critical for regulatin

Trans-NIH Recovery Act Research Support Diabetes is associated with serious cardiovascular complications that include heart failure. Data from studies conducted in animal models and human subjects suggest that alterations in fatty acid metabolism, independent of atherosclerosis, are involved in

Trans-NIH Recovery Act Research Support A fundamental assumption in viral research is that viral genes confer pathogenicity. Viral genetics is essential to understanding viral disease, but genetic approaches assume that one knows what genes the virus has. If a virus is significantly more comp

ARRA - Head Start The YWCA Head Start program realized significant outcomes resulting from the allocation and distribution of ARRA funding. Through the use of ARRA COLA funding, permanent salary increases were provided to all staff resulting in heightened staff morale.

Trans-NIH Recovery Act Research Support This application seeks support from the National Heart, Lung & Blood Institute (NHLBI) through the NIH P30 mechanism (OD-09-005) for resources to recruit a newly independent assistant professor to the Diabetic Cardiovascular Disease Center (DCDC) at Washi

We have been awarded a contract to provide tumor types to the NCI for The Cancer Genome Atlas (TCGA) project. Specifically to establish a Tissue Source Site (TSS) Network capable of delivering clinically annotated biospecimens through either or both retr

Trans-NIH Recovery Act Research Support Lung transplant (LTx) is a viable treatment option for a variety of end-stage pulmonary parenchymal and vascular diseases. Advancements in surgery, immunosuppression and recipient selection have significantly improved perioperative survival following LTx.

Trans-NIH Recovery Act Research Support The long-range objective of the proposed research is to refine, evaluate, and disseminate an Internet-based intervention to prevent eating disorders (EDs) and comorbidities in college-age women. EDs are highly prevalent among college women and can lead to

ARRA Strengthening Communities Fund The goal of this program is to build the capacity of our nonprofit partners in order to address the broad economic recovery issues present in our community, including helping low-income individuals secure and retain employment, earn higher wages, obtain b

ARRA Strengthening Communities Fund ARRA Strenthening Communities Fund Nonprofits Capacity Building Program - The goal of the program is to build the capacity of our nonprofit partners in order to address the broad economic recovery issues present in our community, including helping low-inc

ARRA Health Center Integrated Services Development Initiative[g1] Many uninsured and underinsured patients in the St. Louis, Missouri region lack a medical home in which to receive high quality primary care. As a result, there exists in St. Louis a sizeable population of medically underserved with d dimished and disparat... Show more

Trans-NIH Recovery Act Research Support A wide variety of genetic or drug-induced mental health disorders have been linked to problems in regulation of gene expression. Gene expression is regulated by specialized proteins called transcription factors (TFs), which work with a few nuclear adaptor

Trans-NIH Recovery Act Research Support This application addresses Broad Challenge Area (15): Translational Science and Specific Challenge Topic, 15-MH-109: Prefrontal cortex regulation of higher brain function and complex behaviors. The goal of this project is to understand the neural mechanis

Trans-NIH Recovery Act Research Support This application addresses broad Challenge Area (08) Genomics and specific Challenge Topic, 08-CA-09-003: Micro-RNAs in Cancer. The objective of this challenge grant is to define the contribution of microRNAs (miRNAs) to transformation in acute myelogenou

Trans-NIH Recovery Act Research Support This application addresses Broad Challenge Area (04) Clinical Research and specific Challenge Topic, 04-DK-106: Preservation/Recovery of endogenous insulin secretion. Diabetes is a serious and common metabolic disorder that afflicts 18 million Americans w

Trans-NIH Recovery Act Research Support While the Washington University Institute of Clinical and Translational Sciences (ICTS) has made significant progress in deploying comprehensive resources to facilitate research, the ICTS is still hampered by inefficient communication and coordination ac

Recovery Act Comparative Effectiveness Research - AHRQ WASHINGTON UNIVERSITY COMPARATIVE EFFECTIVENESS ADMINISTRATIVE DATA REPOSITORY The PI wishes to use the existing abstract as reported in the NIH reporter as her Award Description for ARRA reporting purposes.

Trans-NIH Recovery Act Research Support The long term goal of this continuing work is to quantitatively characterize skeletal muscle structure and function noninvasively with nondestructive imaging modalities, and to implement robust methods for diagnosing disease and improving clinical managem

ARRA Health Center Integrated Services Development Initiative[g1] The Award will address the immediate need for our community to have access to more effective, high-quality healthcare. This will be accompliahed through the acquisition of new technologically-advanced medical and dental equipment and e electronic medical re... Show more

Trans-NIH Recovery Act Research Support Alzheimer's disease (AD) is the most common neurodegenerative disease in the US, affecting over 4 million people over the age of 65 years. As the population of the world ages the number of people suffering from AD will increase rapidly during the coming

Trans-NIH Recovery Act Research Support The parent grant entitled Photoacoustic/optical/ultrasonic imaging of sentinel lymph nodes and metastases covers the development of photoacoustic tomography (PAT) and multimodality imaging of SLN and metastases. PAT is one of the fastest growing biomedica

Trans-NIH Recovery Act Research Support The urinary tract (UT) is a common site of infection in humans, with an estimated 8 million outpatient visits in the U.S. and an estimated cost exceeding $2.5 billion annually. The most frequent sufferers are women, with a 50% lifetime chance of developin

Trans-NIH Recovery Act Research Support Atherosclerotic coronary artery disease is the largest single killer of Americans and the most complex subset of these patients have decreased heart function because of the blockage in their coronary arteries. Coronary bypass surgery and coronary stentin

Trans-NIH Recovery Act Research Support Leishmaniasis is a major health problem in humans and is caused by the protozoan parasite Leishmania. Depending on the species, Leishmania-induced pathology ranges from self-healing, cutaneous lesions to fatal, visceral diseases. Our laboratory has focuse

ARRA - Health Information Technology Professionals in Health Care The Midwest Community College Health Information Technology Consortium provides training in six work force roles to support electronic health records implementation across 10 Midwest states through campus-based training, distance learnrning and connections ... Show more

Trans-NIH Recovery Act Research Support One of the pathological hallmarks of Alzheimer's Disease (AD) is the senile plaque, principally composed of the Abeta peptide. Abeta1-42, the 42 amino-acid peptide fragment of the amyloid precursor protein (APP), has a striking propensity to aggregate int

NOTE: This project was funded on 11/05/09 and began 11/16/09. There has been a follow-on task order awarded to continue support beyond 07/15/10; which was completed as of 09/30/10. The A-TEK Team was awarded the requirement to provide support for the US

Trans-NIH Recovery Act Research Support We believe that our most recent work studying the electrical properties of neurons of the brain represents abreakthrough in understanding how potassium channels control the excitability of neuronal electrical activity,and may have a significant impact on

Trans-NIH Recovery Act Research Support Evidence suggests that the pathology of Alzheimer's disease (AD) begins to accrue as many as 10-15 years prior to the earliest signs and symptoms of cognitive decline characteristic of AD. This period, during which pathology is developing but individuals

Trans-NIH Recovery Act Research Support Free radicals, or more specifically, reactive oxygen species (ROS), have been proposed as critical mediators of dysfunction and disease for a large number of disorders, including many in the brain related to Alzheimer's disease, accelerated aging, other n

Trans-NIH Recovery Act Research Support Damage to inner ear hair cells is a leading cause of human deafness and balance disorders and affects >10% of the world's population. Mammals cannot regenerate their hair cells. However, birds (and other lower vertebrates) can regenerate these cells. This

Trans-NIH Recovery Act Research Support The long-term goal of this research initiative remains to delineate the cytoprotective role of proinflammatory cytokines in myocardial ischemia reperfusion (I/R) injury. We previously made the observation that the cytoprotective effects of tumor necrosis

Trans-NIH Recovery Act Research Support This proposal is in response to Notice Number NOT-OD-09-088 of the American Recovery and Reinvestment Act of 2009. We request funding for the first two years of the revised grant application 1R01AI73718-01A2, with changes in scope approved by the NIAID P

Trans-NIH Recovery Act Research Support Diabetes mellitus is associated with a cardiomyopathy that occurs in the absence of hypertension or coronary artery disease and that is characterized by ventricular hypertrophy, decreased ventricular diastolic relaxation, and a reduced peak filling rate.

Trans-NIH Recovery Act Research Support The loss of sensory hair cells from the human ear is a leading cause of hearing and balance disorders. Although the potential for regeneration in the human ear is very limited, the ears of nonmammalian vertebrates can quickly regenerate after injury. A de

Trans-NIH Recovery Act Research Support Diagnosis and treatment of various pathologic conditions can be achieved by integrating multimodal imaging systems that furnish complementary information to improve patient management. The availability of high-resolution tomography systems, fast computers

Trans-NIH Recovery Act Research Support Toxoplasma gondii is a widespread protozoan parasite of wild, domestic, and companion animals that also commonly infects humans. Severe infections are normally only found in immunocompromised patients, including HIV infection, cancer chemotherapy, organ t

Trans-NIH Recovery Act Research Support Project is currently on NCE through 8/31/12. arious members of the Ras superfamily of small GTPases, which comprise over 200 proteins, are expressed selectively in all cells, where they perform a range of cellular functions. A well-studied subfamily is th

Trans-NIH Recovery Act Research Support Hypoxic cell death in the form of stroke and myocardial infarction is the largest single cause of death in theUnited States. The fundamental molecular mechanisms of hypoxic cell death are incompletely understood.Studies in genetically tractable model orga

Trans-NIH Recovery Act Research Support The overall goal of the proposed study is to identify neurophysiological and behavioral markers of sensitivity to smoking cessation treatment. Although smoking widely recognized as the major preventable cause of death and substantial proportion of smokers

Trans-NIH Recovery Act Research Support Silent Cerebral Infarct (SCI) is the most common cause of severe neurological disease in children with sickle cell anemia, occurring in 22% of this population prior to their 18th birthday. The overall goal of this trial is to determine whether blood trans

Trans-NIH Recovery Act Research Support The overall aim of this project is to develop novel conformal small-animal irradiator, suitable for studying genetic markers of radiation response and radiobiological models at therapeutic dose levels. There has been a revolution in functional imaging tha

Trans-NIH Recovery Act Research Support Many individuals with Parkinson disease (PD) experience a reduction in mobility with gait difficulties thatinclude impaired turning that can trigger freezing. These turning difficulties are particularly critical since fallsduring turning carry an eightfol

Trans-NIH Recovery Act Research Support Cardiovascular disease (CVD) and its associated risk factors such as hypertension and dyslipidemia constitute a major public-health burden due to increased mortality and morbidity and rising health care costs. Massive epidemiological data are needed to de

Trans-NIH Recovery Act Research Support HSV-1 virus infection of the cornea is a leading cause of infectious blindness. Corneal damage results from virus-induced inflammation of the cornea. These studies will address the role that corneal anti-inflammatory proteins play during herpetic c

Trans-NIH Recovery Act Research Support Project is on No Cost Extension through 5/31/12. This is a modified abstract. The first paragraph is the original project description; this is followed by a short description of a recent modification to this project. We cloned the novel inhibitory recep

Trans-NIH Recovery Act Research Support Elderly persons who have suffered a disabling medical event, such as a hip fracture, are likely to develop depression. Late-life depression (LLD) adversely affects acute medical rehabilitation, increasing the risk for persistent depression and disability.

ARRA Health Center Integrated Services Development Initiative[g1] HRSA-09-218 Increase Demand for Services. This project allowed PHC to recruit and retain 8.5 staff persons to provide open access services, nurse triage and clinical support.IDS funding will help the health center retain 2.5 FTEs that t would have been trim... Show more

Trans-NIH Recovery Act Research Support This proposal includes two components to increase the pace of discovery in our project titled 'Viral Triggers of Alloimmunity and Autoimmunity in Pediatric Lung Transplantation' (1U01AI077810-01), address the economic stimulus priorities, and provide repo

Trans-NIH Recovery Act Research Support Congenital anomalies affecting the kidney and urinary tract are among the most common serious birth defects. While there is significant clinical and increasing genetic data on these disorders, the disease mechanisms are not well understood. The proposed s

Trans-NIH Recovery Act Research Support This ARRA-supported project (3R01 EY012543-10S1) investigates the role of the retinal transcription factor CRX in photoreceptor development, maintenance and diseases. CRX is a key member of the photoreceptor transcription factor network that regulates the

Trans-NIH Recovery Act Research Support Human- and hominoid-specific genes are among the most interesting genes in the human genome. These genes are likely to have evolved by duplication of segments of DNA ( a process called segmental duplication) that occurred during primate expansion. New gen

Trans-NIH Recovery Act Research Support Transplantation is the ideal therapy for end stage heart and end stage kidney failure, but allograft survival and function remain suboptimal. This CTOT renewal application will build upon the findings resulting from the previous 4 years of studying biomar

Trans-NIH Recovery Act Research Support The breast cancer susceptibility gene 1 (Brca1) plays a key role in both hereditary and sporadic mammary tumorigenesis. However, the extent to which BRCA1-activated molecular pathways contribute to its tumor suppressor activity also remains unclear. Activ

Trans-NIH Recovery Act Research Support Mucopolysaccharidosis I (MPS I) and MPS VII are lysosomal storage diseases in which glycosaminoglycans (GAG) accumulate due to deficient activity in alpha-L-iduronidase and beta-glucuronidase, respectively. This results in multisystemic disease involving

Trans-NIH Recovery Act Research Support In the heart, a major sensor of the metabolic state, and hence a potentially major player in ischemia, is the ATP-sensitive potassium (KATP) channel, which links metabolic state to electrical excitability. This project seeks to understand the molecular ba

Trans-NIH Recovery Act Research Support There are no effective treatments for hepatic fibrosis. There+???s an urgent need to develop therapeutic agents that delay/reverse hepatic fibrosis. We believe that PEG-TGF-B peptantagonist should be an ideal candidate for treating human liver fibrosis.

Trans-NIH Recovery Act Research Support The encapsulated fungus Cryptococcus neoformans is responsible for life-threatening disease, particularly in the context of compromised immunity, and current therapy is not adequate. Extracellular glycans define the interface between this opportunistic pa

ARRA Health Center Integrated Services Development Initiative[g1] The overall purpose of the Increased Demand for Services-IDS funding to Myrtle Hilliard Davis Comprehensive Health Centers? (MHDCHC) was to increase accessibility to dental services and to retain four FTEs in the Outreach department. To improve accessibi... Show more

Trans-NIH Recovery Act Research Support Restoration of functional grasping would be of great benefit to people with hemiparesis post stroke. While task-specific training may be the best way to promote functional recovery, implementing such training for grasping is difficult because there are an

Trans-NIH Recovery Act Research Support Patients with advanced cervical cancer are treated with chemoradiation. Pretreatment positron emission tomography (PET) with 18F- fluorodeoxyglucose (FDG) is routinely utilized for these patients to determine the extent of their disease, to aid in radiati

Trans-NIH Recovery Act Research Support Sepsis is the leading cause of death in most intensive care units with over 210,000 people succumbing tooverwhelming infection (or the resultant multiple organ failure) in the United States annually. A recentepidemiologic study estimated that 750,000 peop

Trans-NIH Recovery Act Research Support The long-term goal of this research is to establish the stress response in Drosophila as a model that can be utilized to elucidate how gender and sexual maturity affect recruitment of individual neurons into functioning neuronal circuits.

Trans-NIH Recovery Act Research Support This is a competitive revision in response to NOT-OD-09-058, the ARRA call for Competitive Supplement Applications. In the past decade there has been a growing awareness of the disabling effects of impaired cognition in individuals with schizophrenia and

Trans-NIH Recovery Act Research Support The ultimate goal of this project is to develop Positron Emission Tomography (PET) imaging agents to measure the level of vesicular acetylcholine transporter (VAChT) expression in the human brain. VAChT is a unique and novel marker for cholinergic neuron

Trans-NIH Recovery Act Research Support Identification of even a single gene that contributes to a complex trait provides insight into its molecular basis. However, multiple genes need to be identified if different genes affect a trait through different biological processes or pathways. In the

Trans-NIH Recovery Act Research Support A Workforce Development Administrative Supplement was requested to enhance the existing clinical and translational research training programs at the Washington University (WU) Clinical Research Training Center (CRTC). The goal of the CRTC is to provide ou

Trans-NIH Recovery Act Research Support This application addresses broad Challenge Area (03) Biomarker Discovery and Validation, and specific Challenge Topic, 03-MH-101 Biomarkers in mental disorders. The variability of treatment outcome in PTSD, the high risk of relapse and the fact that only

Trans-NIH Recovery Act Research Support Chronic itch or pruritus represents a significant clinical problem for which no effective drugs are available. Molecular and cellular mechanisms of chronic pruritus are not well understood and understudied. Recent identification of the first itch-specific

Trans-NIH Recovery Act Research Support Breast cancer is a difficult disease to manage because it is comprised of a wide spectrum of tumor subtypes with different biological characteristics, therapeutic responses and clinical outcomes. A biomarker-based classification of breast cancer that effe

Trans-NIH Recovery Act Research Support Influenza viruses are a frequent cause of acute, severe respiratory illness, but the role of these types of viruses in triggering chronic inflammatory lung disease is uncertain. We previously reported that a common type of paramyxovirus (i.e., mouse parai

Trans-NIH Recovery Act Research Support We propose to acquire an Applied Biosystems Sciex QTRAP 5500 hybrid triple quadrupole-linear ion trap mass spectrometer (MS) for LC/MS/MS analyses of biomedically important complex lipids. This program will benefit from the sensitivity and versatility of

Trans-NIH Recovery Act Research Support Project ended 1/31/12. ***CLOSEOUT DOCS. SUBMITTED TO NIH 5/21/12*** Upon contact with bone, matrix-derived signals in the RANKL-induced osteoclast (OC) prompt the cell to polarize its cytoskeleton, eventuating in formation of an isolated microenvironme

Trans-NIH Recovery Act Research Support The project titled G?A longitudinal MRI study of brain development in Fragile X syndromeG? aims to study very early brain and behavior development at 6, 12 and 24 months in infants with fragile X syndrome (FXS). Investigators use Magnetic Resonance Imag

Trans-NIH Recovery Act Research Support HIV causes AIDS in humans. Integration of HIV DNA by integrase into chromosomes is necessary for virus replication which cause AIDS. We investigate the mechanisms associated with integration and prevention of integration by clinical inhibitors.

Trans-NIH Recovery Act Research Support Project is currently on a No Cost Extension through 7/31/12. Many aspects of gene function are coordinated by changes in the epigenome, which include dynamic revisions of chromatin modifications, genome packaging, subnuclear localization, and chromosome c

Trans-NIH Recovery Act Research Support Cone photoreceptors function under daylight conditions and are essential for color perception and vision with high temporal and spatial resolution. A remarkable feature of cones is their ability to remain functional in bright light which requires powerful

Trans-NIH Recovery Act Research Support Dendritic cells (DCs) play an essential role initiating and guiding immune responses toward intestinal pathogens and non-pathogens. The intestine contains a population of DCs that are uniquely positioned at the interface of the host with the environment.

Trans-NIH Recovery Act Research Support One third of Americans suffer from some form of chronic pain, (30% being resistant to analgesic therapy), making it a significant health problem with serious economic impact (estimated cost of approximately $100 billion annually).1 Chronic pain associated

Trans-NIH Recovery Act Research Support HSV-1 infects half of individuals in the United States, and causes 400,000 new painful, sight-threatening eye infections each year. Our goal is to develop a prophylactic vaccine to prevent debilitating consequences of these infections.

Trans-NIH Recovery Act Research Support This requested NCRR ARRA supplement submitted under the 'Enhancing NCRR Pilot Project Mechanism' priority provided funds to support two meritorious translational research projects selected from among the best scoring grant applications in Washington Unive

Trans-NIH Recovery Act Research Support Phototransduction in retinal rods relies on signaling mediated by the heterotrimeric G-protein transducin. We investigate the involvement of the transducin beta-gamma complex in visual signal propagation and amplification, as well as in the morphogenesis

Trans-NIH Recovery Act Research Support While it has long been recognized that the wide array of polymorphisms in major histocompatibility complex (MHC) in combination with the direct role of MHC in activation of T cells through the T cell receptor (TCR) makes MHC the primary antigenic barrier

Trans-NIH Recovery Act Research Support he central theme of the Program Project is to understand the innate host defense mechanisms against inhaled pathogens by the two pulmonary collectins, surfactant proteins A and D (SP-A, SP-D). This understanding is important not only in the context of pre

ARRA - Head Start The YWCA Head Start program realized significant outcomes resulting from the allocation and distribution of ARRA funding. Through the use of ARRA COLA funding, permanent salary increases were provided to all staff resulting in heightened staff morale.

Trans-NIH Recovery Act Research Support Approximately 12-20 million people are infected with T. cruzi and 50,000 people die each year from Chagas disease. People in the US are at risk of T. cruzi infection through blood transfusions and organ donations originating from infected persons, and the

ARRA Health Center Integrated Services Development Initiative[g1] The award description is Increased Demand for Services (IDS). One full time equivalent internal medicine physician was retained. The goal was to see 160 new patients during the period of the award of which 117 would be uninsured.For ththe two year period we... Show more

Trans-NIH Recovery Act Research Support he central theme of the Program Project is to understand the innate host defense mechanisms against inhaled pathogens by the two pulmonary collectins, surfactant proteins A and D (SP-A, SP-D). This understanding is important not only in the context of pre

Trans-NIH Recovery Act Research Support Heterotrimeric G proteins (123) mediate the majority of signaling pathways in mammalian cells. It is long held that G protein function is localized to the plasma membrane. Observation of the spatio-temporal dynamics of G protein localization in living mam

Trans-NIH Recovery Act Research Support West Nile virus (WNV) is an NIAID Category B infectious agent that can cause severe encephalitis, encephalopathym and paralysis in humans and other animals. Pathogenic WNV has emerged into the Western hemisphere and presents a serious public health threa

Trans-NIH Recovery Act Research Support The overall goal of this project is to define the role of the cellular ESCRT machinery in the budding and release of intralumenal vesicles in multivesicular endosomes and in the topologically related process of viral budding. The specific aims are (1) to

Trans-NIH Recovery Act Research Support Small laboratory animal models such as mice, rats and hamsters are widely used throughout the biomedical research community at Washington University in St. Louis and other scientific institutions. With the recent revolution in molecular biology, transgeni

Trans-NIH Recovery Act Research Support Diamond Blackfan Anemia is a rare bone marrow failure syndrome characterized by red cell aplasia, congenital abnormalities and a predisposition to cancer. Heterozygous mutations in ribosomal protein genes have been found in approximately 50% of DBA patie

Trans-NIH Recovery Act Research Support Patients with an acute coronary syndrome (ACS) and comorbid depression have a 2-fold higher risk for recurrent ACS and mortality, worse quality of life, and higher costs of care than nondepressed ACS patients. The strength of these findings prompted the A

Trans-NIH Recovery Act Research Support This proposal is in response to NIDDK RFA-DK-06-014 and is entitled Washington University Diabetes Research and Training Center (WU DRTC). The overall goal is to support centralized resources, facilities, and expertise shared by diabetes investigators at

Trans-NIH Recovery Act Research Support The global aim of this project, proposed under the R21 exploratory/developmental mechanism, is to examine the interplay between genetic factors for substance dependence and the age at onset of drinking or smoking, while advancing our understanding of the

Trans-NIH Recovery Act Research Support Genetic dissection of hypertension (HTN) and co-morbidities, carried out largely through traditional linkage analysis, has mostly been unsuccessful to date in identifying specific genetic variants. Motivated by existing evidence that some of the genetic e

Trans-NIH Recovery Act Research Support This application seeks continued funding for the Washington University CNRU. Since our CNRU was originally funded in 1999, it has served as a nidus for the growth and development of nutrition research at Washington University. The research infrastructure

Trans-NIH Recovery Act Research Support The overarching goal of the Washington University WU Center for Kidney Disease Research (CKDR) is to support centralized resources, facilities, and expertise shared by investigators at WU in order to delineate fundamental mechanisms of renal disease and t

Trans-NIH Recovery Act Research Support Understanding regulatory mechanisms that maintain pluripotent embryonic cells and control differentiation has fundamental relevance to scientific areas central to human health and disease, including stem cell, developmental, and cancer biology. The novel

Trans-NIH Recovery Act Research Support The Ocular hypertension Treatment Study is a large multicenter randomized clinical trial to determinewhether lowering intraocular pressure with topical ocular hypotensive medication in subjects with ocular hypertension prevents or delays the development

Trans-NIH Recovery Act Research Support Identify the barriers in implementing individualized informed consents in routine clinical care. Test the impact of Personalized Risk Information Services Manager (PRISM) on the quality of informed consent, on the use of Bleeding Avoidance Therapies (BAT

Trans-NIH Recovery Act Research Support Parkinson Disease (PD) is a common neurodegenerative disease that affects over 1 million people in North America. Although the cause of PD is unknown, environmental factors are suspected in the majority of cases. Preliminary data from our lab demonstrat

Trans-NIH Recovery Act Research Support Patients with an acute coronary syndrome (ACS) and comorbid depression have a 2-fold higher risk for recurrent ACS and mortality, worse quality of life, and higher costs of care than nondepressed ACS patients. The strength of these findings prompted the A

ARRA Child Care and Development Block Grant Improved Access: $30 1/3 Income Disregard The Missouri Child Care Assistance Program served 397 (unduplicated) households through the $30 1/3 Income Disregard program for this quarter. A total of 694 (unduplicated) children were served. The total expend

Trans-NIH Recovery Act Research Support The overall goal of the exploratory R21 program studies (R21 AI 078237) proposed here is to better understand how the gastric pathogen Helicobacter pylori (Hp) evolves in human populations especially the impact of genetic drift and selection on genes impo

Trans-NIH Recovery Act Research Support Radiotherapy is constrained by toxicity to normal tissues. The parent R01 is focused on the development of increasingly-predictive models of normal tissue toxicity risk as a function of dose and volume of organs irradiated. The current specific aims focus

Trans-NIH Recovery Act Research Support Evolution within coding and noncoding sequences is markedly different. Most proteins are highly conserved, even between distantly related species such as yeast and human. In contrast, cis-regulatory sequences rarely if ever remain conserved between distan

NOTE: This project was funded on 11/05/09 and began 11/16/09. The A-TEK Team has been awarded the requirement to provide support for the USDA Rural Development (RD) Application, Design, Development, Testing and Helpdesk. The A-TEK Team will support RD

Trans-NIH Recovery Act Research Support The Siteman Cancer Center (SCC) Program for the Elimination of Cancer Disparities (PECaD) is a multidisciplinary community-focused program established to eliminate pervasive disparities of cancer education, prevention, and treatment. The SCC Senior Leader

Trans-NIH Recovery Act Research Support The Alvin J. Siteman Cancer Center (SCC) at Washington University School of Medicine and Barnes-Jewish Hospital received NCI designation as a Clinical Cancer Center in 2001, and as a Comprehensive Cancer Center in 2004. The SCC is composed of eight multid

Trans-NIH Recovery Act Research Support This is a supplement to the KL2 Career Development Component of the Washington University CTSA grant in response to the ?Comparative Effectiveness Research, CER, Workforce Development Announcement?: NOT-OD-10-037. The goal of this announcement was to exp

Trans-NIH Recovery Act Research Support The purpose of this ARRA funded Comparative Effectiveness Research (CER) Workforce Development Administrative Supplement is to expand the number of researchers qualified to oversee and conduct CER, to promote job creation and economic development and to a

Trans-NIH Recovery Act Research Support Guatemala is undergoing an epidemiological transition and today faces the 'double-burden' disease problem of significant infectious and non-infectious disease. However, prevalence and mortality rates of non-infectious disease are limited by an unreliable,

Trans-NIH Recovery Act Research Support The applicant has developed evidence that exposure of the developing brain to anesthetic drugs causes developing neurons to die by a process referred to as 'apoptosis'. These findings are potentially important in a public health context, because in the U

Trans-NIH Recovery Act Research Support This supplement will accelerate the tempo of building a comprehensive multidimensional discovery platform from which investigators can launch further hypothesis-driven studies on inflammatory bowel diseases pathogenesis. It will advance the objectives of

Trans-NIH Recovery Act Research Support Cardiovascular diseases (CVD) affect millions of people in US and across the world. There is strong evidence of a genetic component in cardiovascular diseases (CVD) and related traits. An emerging consensus is that both genes and environment and, perhaps

Trans-NIH Recovery Act Research Support Examines the activity of the protein Echinoid, which regulates both the number and type of photoreceptors present in the Drosophila retina to further the goal of being able to replace photoreceptors in people with retinal degeneration.

Trans-NIH Recovery Act Research Support Breathing is generated by neurons in the brainstem. One limitation of our current understanding of the neural circuits underlying breathing is the lack of genetic markers for the unambiguous identification of specific neural populations. We hypothesize

Trans-NIH Recovery Act Research Support The proposed experiments will elucidate mechanisms involved in development and differentiation of a highly specialized neuronal epithelial cell type: the rod photoreceptor cell. The rd1 mouse model of juvenile retinitis pigmentosa will be used to gain ins

Trans-NIH Recovery Act Research Support This research explores mechanisms of DNA recombination and repair and is important for understanding origins of multiple diseases including premature aging, cancer and developmental disorders.

Trans-NIH Recovery Act Research Support The overall goal of this supplement is to accelerate our ability to understand how the brain uses visual information to generate reaching movements. Reaching towards visual targets is critical for normal daily function, and is a good model system for mor

Trans-NIH Recovery Act Research Support This is a collaborative community engagement ARRA supplement request. There are over 80,000 clinical trials conducted each year in the US, and yet, less than 1 percent of the population participates in them. The so-called ?leaky pipe of clinical trial par

Trans-NIH Recovery Act Research Support The prevalence of childhood overweight (CO) has tripled in recent decades and there is growing recognition of environmental factors related to the rapid increase of this significant public health problem. Socio-ecological models provide a strong theoretic

Trans-NIH Recovery Act Research Support Our understanding of (UCPPS) such as interstitial cystitis/painful bladder syndrome (IC/PBS) and chronic prostatitis/chronic pelvic pain syndrome, (CP/CPPS) is poor. The objective of our proposal is to investigate the etiology, pathophysiology, and epidem

Trans-NIH Recovery Act Research Support The overall goal of this project is to develop the lateral flow assay for detecting complement levels and complement activation status in a patient. This assay will give results in seconds versus either hours or days that normal complement lab assays have

Trans-NIH Recovery Act Research Support Microtubule-organizing centers (MTOCs) or centrosomes play important roles in all eukaryotic cells. MTOCs are involved in mitotic spindle organization and in an increasing number of other fundamental cellular processes. Defects in MTOCs contribute to sp

Trans-NIH Recovery Act Research Support Children with Cornelia de Lange syndrome (CdLS) display slow growth before and after birth, and are afflicted with mental retardation and defects in limbs and organs such as the heart. CdLS is caused by changes in genes that are also present in yeast and

Trans-NIH Recovery Act Research Support We are currently conducting what we believe is the first large-scale study to address the effectiveness of auditory training longitudinally, to compare training methods, and to identify patient variables that predict benefit. The purpose of this applicati

Trans-NIH Recovery Act Research Support Our 'metagenome' is a composite of H. sapiens genes and genes present in the genomes of the trillions of microbes that colonize our adult bodies. 'Our' microbial genomes (microbiome) encode metabolic functions we have not had to evolve on our own, but rem

Trans-NIH Recovery Act Research Support he central theme of the Program Project is to understand the innate host defense mechanisms against inhaled pathogens by the two pulmonary collectins, surfactant proteins A and D (SP-A, SP-D). This understanding is important not only in the context of pre

Trans-NIH Recovery Act Research Support The molecular mechanisms underlying uterine smooth muscle excitation during pregnancy are unknown, and this deficit has hampered the development of effective therapies for uterine dysfunction. The maintenance of uterine quiescence during pregnancy require

Trans-NIH Recovery Act Research Support The exact pathogenesis of arthritis in children or adults is not known, but several cells contribute to the development of autoimmune arthritis including T and B lymphocytes, synovial cells, macrophages, neutrophils and osteoclasts (OC) [1-3]. Identifying

Trans-NIH Recovery Act Research Support This request for supplementary funds for R01-GM-077231 is to fund a collaboration between the lab of Professor Kathleen Hall at Washington University School of Medicine, St Louis, MO (parent grant) and that of Associate Professor Alan Van Orden at Colorad

Trans-NIH Recovery Act Research Support We developed an analytical protocol to purify and enrich biotinylated histones from human cells for subsequent analysis by mass spectrometry. Our protocol is based on acid xtraction of bulk histones from Jurkat cells, followed by fractionation of histones

Trans-NIH Recovery Act Research Support The Overall Goal in this collaborative research project is to assess the effectiveness of rTMS in a large number of tinnitus patients and to assess whether there are patient and clinical factors that are predictors of outcome. In the original application

Trans-NIH Recovery Act Research Support This project will empirically test whether quantitative information about drug dose effects on brain function can be extracted from functional Magnetic Resonance Imaging (fMRI) We have developed a method for determining the ED50 - the drug dose required t

Trans-NIH Recovery Act Research Support The supplemental request under NOT-OD-09-056 supports the science of the parent project AA12640 Alcoholism: epidemiologic high risk family study and the aims of the Recovery Act through its dual objectives. The first is to retain project staff to enable

Trans-NIH Recovery Act Research Support One of the major objectives of cognitive neuroscience research has been to understand how the brain carries out skilled reading, and how, in development, skilled reading is acquired. The overarching concept of the parent R01 proposal is that information a

Trans-NIH Recovery Act Research Support We developed an analytical protocol to purify and enrich biotinylated histones from human cells for subsequent analysis by mass spectrometry. Our protocol is based on acid xtraction of bulk histones from Jurkat cells, followed by fractionation of histones

Trans-NIH Recovery Act Research Support The random generation of T cell receptor (TCR) sequences ensures a TCR repertoire capable of recognizing a wide variety of pathogens. However, study of the TCR repertoire is hampered by this great diversity. To overcome this issue, we have used a fixed TC

ARRA Child Care and Development Block Grant Improved Access: $30 1/3 Income Disregard The Missouri Child Care Assistance Program served 397 (unduplicated) households through the $30 1/3 Income Disregard program for this quarter. A total of 694 (unduplicated) children were served. The total expend

Trans-NIH Recovery Act Research Support Studies performed under this grant have provided a foundation for understanding how drugs and other substances are distributed in the inner ear following local or systemic applications. Central to this work has been the development of computer programs th

Trans-NIH Recovery Act Research Support The long-term objectives of this application are to understand how hormones transduce signals to cells. The general strategy is to focus on a superfamily of seven transmembrane-spanning receptors that bind hormones and mediate signals via G proteins. The

Trans-NIH Recovery Act Research Support This supplement will greatly increase the tempo of gene mapping research performed using the LG/J and SM/J mouse strains by providing measures of gene expression across the genome in a variety of tissues and by precisely identifying the recombination brea

Trans-NIH Recovery Act Research Support Characterizing the 3-year course of cannabis involvement in NESARC Cannabis is the most commonly used illegal psychoactive substance in the United States and in developed nations. For instance, in the U.S., over 40 percent of 12th graders reporting a life

Trans-NIH Recovery Act Research Support The Alvin J. Siteman Cancer Center (SCC) at Washington University School of Medicine and Barnes-Jewish Hospital received NCI designation as a Clinical Cancer Center in 2001, and as a Comprehensive Cancer Center in 2004. The SCC is composed of eight multid

Trans-NIH Recovery Act Research Support This application is directly responsive to the goals of the American Recovery and Reinvestment Act, which are to accelerate the tempo of scientific research and to invest in economic impact through improved clinical care and job creation. The ability to c

Trans-NIH Recovery Act Research Support Preterm birth is a major public-health issue because of its increasing incidence combined with the frequent occurrence of subsequent behavioral, neurological, and psychiatric challenges faced by surviving infants. Approximately 10-15% of very preterm chil

Trans-NIH Recovery Act Research Support he central theme of the Program Project is to understand the innate host defense mechanisms against inhaled pathogens by the two pulmonary collectins, surfactant proteins A and D (SP-A, SP-D). This understanding is important not only in the context of pre

The purpose of this task order is to support various VRC Universal Influenza studies. Specifically,the EMMES Corporation will provide all necessary technical, clinical, and management services in order to support four phase-I clinical trials (2 adult,2 pe

Trans-NIH Recovery Act Research Support Children with Cornelia de Lange syndrome (CdLS) display slow growth before and after birth, and are afflicted with mental retardation and defects in limbs and organs such as the heart. CdLS is caused by changes in genes that are also present in yeast and

Trans-NIH Recovery Act Research Support Administrative Supplement Project Description People with diabetes and peripheral neuropathy (DM+PN) have substantial lower extremity impairments, functional limitations and disability. In addition to muscle weakness and poor balance, they also are at hig

Trans-NIH Recovery Act Research Support Children with liver disease present major challenges. These diseases are collectively important because of high morbidity, mortality, and public health impact. Management is often ineffective, with cirrhosis, liver failure and liver transplantation as com

Trans-NIH Recovery Act Research Support Red blood cell transfusions are extremely common medical interventions with more than 11 million red blood cell units transfused in the United States and 75 million worldwide. Yet, it remains unclear when patients should receive red blood cell transfusion

Trans-NIH Recovery Act Research Support In this study, we aim to identify gene products responsible for traits dependent upon the epigenetic element known as the yeast (PSI plus) prion. This system enables detailed investigation into the underlying mechanisms of phenotypic expression of comple

Trans-NIH Recovery Act Research Support Elucidation of the molecular mechanisms whereby PARP-1 regulates IL-10 gene expression will enable us identify key steps in the regulatory pathway that may be explored as potential targets of therapeutic intervention in juvenile arthritis. Moreover, the p

Trans-NIH Recovery Act Research Support The mandate to realize surrogate endpoints in the context of human clinical trials with conditionally replicative adenovirus (CRAd) agents has thus suggested the utility of imaging analysis. In theory, this type of assay could provide critical information

Trans-NIH Recovery Act Research Support This is a request for an administrative supplement to enable the successful conduct of Project 1, 'Preclinical Alzheimer's disease predicts poststroke dementia' (JC Morris, Project Leader), of the program project grant, 'Healthy Aging and Senile Dementia'

To design and test a method of intervention that has the capacity to promote engagement and adherence to treatment, foster recovery and reduce or prevent disability in patients experiencing a first episode of schizophrenia and related psychotic disorders.

Trans-NIH Recovery Act Research Support This CLIN supplement proposes four goals that extend studies outlined in the parent grant 'Effects of Asymmetric Hearing in Acoustic Listeners and Cochlear Implant Users'. The premise of the parent grant is that listening with just one ear seriously deg

Trans-NIH Recovery Act Research Support We will use state-of-the-art metagenomic approaches to study the microbiome of the widespread human disease, chronic periodontitis. There is almost no information about the microbial community of this disease at the metagenomic level. The Human Microbiome

Trans-NIH Recovery Act Research Support College students have high rates of alcohol problems. Exercise has numerous physical and mental health benefits, and data suggest that students who engage in exercise regularly are less likely to drink heavily. This project seeks to examine whether engagi

Trans-NIH Recovery Act Research Support Many physiological processes function efficiently within a well-controlled pH range and significant deviations from this range typically are indicative of pathologic conditions. Within cells, maintenance of a pH gradient in different organelles allows for

Trans-NIH Recovery Act Research Support Perhaps one half of disease gene alleles are the result of mutations in non-coding sequence, rather than in protein coding sequences. Understanding the nature of disease, developing reliable diagnostics for disease, and relating different alleles to diff

Trans-NIH Recovery Act Research Support Preterm birth is a major public-health issue because of its increasing incidence combined with the frequent occurrence of subsequent behavioral, neurological, and psychiatric challenges faced by surviving infants. Resting state fcMRI is an ideal method to

Trans-NIH Recovery Act Research Support Globally, resistance to antimicrobial agents is on the rise, and new antimicrobial agents are urgently needed to counter severe human pathogens such as malaria and resistant bacteria. Translational efforts towards drug development depend on high-throughpu

Trans-NIH Recovery Act Research Support Although the regulation of gene expression has been intensively studied in the yeast S. cerevisiae, much about this process remains unknown. This is exemplified by our inability to predict, as opposed to explain, the expression pattern of any gene given i

Trans-NIH Recovery Act Research Support The auditory system has evolved for the effective processing of auditory information important for the species, so the functional organization of the cerebral speech areas and neural mechanisms for processing speech in humans cannot be explored without di

Trans-NIH Recovery Act Research Support This request for a research employment opportunity for a postdoctoral student (fellow) will aid investigation of lower extremity movement impairments in individuals with chronic patellofemoral pain. The proposal would help achieve the goals of the ARRA by

Trans-NIH Recovery Act Research Support It has been shown that peripheral clearance of amyloid beta peptides reduces amyloid beta peptide levels in the brain through what has been termed a 'sink effect'. We have exploited this 'sink effect' by showing that the peptidase neprilysin, when express

Trans-NIH Recovery Act Research Support While therapeutic advances have led to an improvement in survival for many types of malignancies, survival for patients diagnosed with lung cancer or pulmonary metastatic disease remains grim. Development of novel therapeutic strategies is necessary in o

Trans-NIH Recovery Act Research Support Project Summary/AbstractOsteoarthritis will affect 50 million Americans by 2020. The disease process ischaracterized by the aberrant gene expression and the inability of cartilage chondrocytesto repair the extracellular matrix leading to cartilage degener

Trans-NIH Recovery Act Research Support Widespread resistance to long-used drugs and to newer quinoline-based drugs has prompted the need to better understand malaria parasite biology and pathogenesis. Egress from the infected RBCs by the invasive stage of the malaria parasite is a fundamental

Trans-NIH Recovery Act Research Support Septins were discovered as mutants defective in cell division in budding yeast. Septins form filaments and compose a ring at the neck between mother and bud. Septins function as a diffusion barrier for mother / bud polarity and as a scaffold for regulator

Trans-NIH Recovery Act Research Support This supplement award is to enhance research in the parent project: Ihh Signaling in Osteoblast differentiation. This project requires a large number of mouse matings, genotyping and in situ hybridization. This supplement is to support an additional tech

ARRA Health Center Integrated Services Development Initiative[g1] The St. Louis Integrated Health Network (IHN) is a Health Center Controlled Network (HCCN) comprised of seven board member organizations and eight participating organizations. It has developed a Primary Care Home Initiative (PCHI), ththe goal of which is t... Show more

Trans-NIH Recovery Act Research Support This grant application is focused on how abnormalities in cellular processing and distribution of the membrane protein CD36 can impact uptake and metabolic targeting of FA. CD36 is a major facilitator of FA uptake in vivo and important to cellular ability

Trans-NIH Recovery Act Research Support Washington University is fortunate to have an outstanding vision research community complementing a largeand busy clinical service. This combination of research and clinical resources make the University anexcellent institution for the training of physici

Trans-NIH Recovery Act Research Support CD36 is a multifunctional membrane protein we identified in 1993 as a facilitator of long-chain fatty acid (FA) uptake. This role of CD36 is now supported by a wealth of in vivo evidence obtained by us and by others. This grant was initially submitted to

Trans-NIH Recovery Act Research Support The ability of enterococci to form biofilms on abiotic materials, their propensity to acquire vancomycin-resistance, and their intrinsic antimicrobial resistance obviate the importance of ongoing research to combat these emerging and ubiquitous pathogens.

Trans-NIH Recovery Act Research Support Gene therapy approaches for diseases of the -globin gene (sickle cell anemia, -thalassemia) will be needed for definitive cures. In this grant, we will use Homology Directed Repair strategies to correct-globin mutations in induced pluripotent stem cells.

Trans-NIH Recovery Act Research Support This ARRA administrative supplement will set up analysis pipelines for cutting-edge neuroimaging analyses, improve recruitment speed and efficiency, and improve the security and reliability of data by creating computerized versions of paper-based tasks an

Trans-NIH Recovery Act Research Support Research supported by the requested ARRA administrative supplement will be used to test the central hypothesis of the parent grant: that R7BP functions as a palmitoylation-regulated trafficking protein for heterodimers consisting of Gbeta5 and any member

Trans-NIH Recovery Act Research Support Our hypothesis in the previous project period was that a pancreatic islet Ca2+-independent phospholipase A2 (iPLA2 beta) is activated upon stimulation with secretagogues and that its products participate in p-cell signaling. We have now cloned iPLA2 beta

Trans-NIH Recovery Act Research Support Kidney disease is huge worldwide health problem that is becoming increasingly prevalent. Primary glomerular disease, both acquired and genetic, represents a significant proportion of these cases, due in part to the incidence of diabetic nephropathy. We ar

Trans-NIH Recovery Act Research Support NAME: Timely End-of-Life Communication to Parents of Children with Brain Tumors. DESCRIPTION: Having a child diagnosed with a cancer that has a poor prognosis is a highly stressful situation and one in which parents need to make very difficult decisions

Trans-NIH Recovery Act Research Support This administrative supplement is associated with the parent grant G?Collectins and Innate Defense against Inhaled Pathogens, Grant # 1-PO1-AI083222-01A2 (B. Seaton, PI). We will use this supplementary funding to extend the parent grantG??s studies on co

Trans-NIH Recovery Act Research Support Short bowel syndrome resulting from diminished intestinal absorptive function is a major cause of morbidity and impaired quality of life. Although transplantation is an alternative for a small subset of selected patients, strategies designed to increase t

Trans-NIH Recovery Act Research Support This request for summer research experiences for science teachers will aid investigation of diabetes-related issues of muscle metabolism. The proposal would help achieve the goals of the ARRA by providing summer employment opportunities, by increasing the

Trans-NIH Recovery Act Research Support Currently there is a lack of technology to integrate in vitro cell culture systems that realistically mimic in vivo environments with an analysis system that can discretely analyze a wide variety of products released from a confluent layer of cells. The g

Aging Congregate Nutrition Services for States ARRA provided funding for Congregate Nutrition Services. Established in 1972 under the Older Americans Act, the program provides meals to older Americans in congregate facilities such as senior centers, adult day centers, and faith-based settings.

NOTE: This project was funded on 11/05/09 and began 11/16/09. There has been a follow-on task order awarded to continue support beyond 07/15/10; which was completed as of 09/30/10. The A-TEK Team was awarded the requirement to provide support for the US

Trans-NIH Recovery Act Research Support As noted in our last progress report, groups of germ free mice have been colonized with four different communities of sequenced human gut symbionts and subsequently subjected to a combination of diet disturbances and invasions with other symbionts. We hav

Trans-NIH Recovery Act Research Support Alzheimer's Disease (AD) is the leading cause of late-onset dementia and is characterized by progressive cognitive decline and memory loss, ultimately leading to death. Over 5 million Americans are currently suffering from AD, and the total costs of AD an

Trans-NIH Recovery Act Research Support The purpose of our ARRA supplement request was to obtain a portion of the funds needed to procure a state of the art laser scanning confocal microscope, an instrument essential for our work on asymmetric divisions. Asymmetric divisions occur when precurso

Trans-NIH Recovery Act Research Support Egr2 is a zinc finger transcription factor that, along with the Nab family of corepressors, is an important regulator of the Schwann cell (SC) myelination program. Egr2-deficient mice as well as mice deficient in both Nab1 and Nab2 manifest defects in per

Trans-NIH Recovery Act Research Support This RO3 addresses the fundamental question related to gonadotropin secretion from the anterior pituitary. Specifically, why FSH is secreted constitutively and LH is primarily released through the regulated pathway. This is an intriguing issue since bot

Trans-NIH Recovery Act Research Support The major goals of this project are to define the role of TSHR in early thyrocyte commitment and identify the regulatory factors and molecular events involved in the specification of thyrocyte fate. These studies may have important implications not only f

Trans-NIH Recovery Act Research Support As an observational study that also serves as a resource for ancillary treatment trials, the multicenter NASH Database study provides a unique opportunity to understand the causes of NASH, identify treatments, and facilitate diagnosis. This supplemen

Recovery Act Comparative Effectiveness Research - AHRQ Coronary CT angiography (CCTA) represents a potentially disruptive technology in terms of its impact on the clinical evaluation and management of coronary artery disease (CAD). This was highlighted by its inclusion in the Consensus Report on Inititial Natio... Show more

Trans-NIH Recovery Act Research Support This is a request for a Recovery Act Administrative Supplement to grant R01 AI054483 entitled 'Immunity and Pathogenesis of a Novel Norovirus' in response to Notice NOT-OD-09-056. The goal of the parent grant is to examine the pathogenesis of, and immuni

Trans-NIH Recovery Act Research Support This research project will investigate the neural circuits underlying fundamental cognitive learning abilities in deaf children with cochlear implants. This knowledge is important because it will help elucidate why many deaf children display language lear

Trans-NIH Recovery Act Research Support The goal of this project is to enable the investigation of the salvation and electrostatic properties of macromolecules in biomedical research by supporting the maintenance and continued development of the open-source Adaptive Poisson- Boltzmann Solver an

Trans-NIH Recovery Act Research Support Hh signaling plays a fundamental role in both development and homeostasis of a wide variety of tissue types in mammals. The parent grant proposed three aims to investigate both the molecular mechanism underlying Ihh signaling in skeletal development, and

Trans-NIH Recovery Act Research Support Mediomics is requesting funds to purchase a new fluorescence plate reader with the capability of performing time-resolved flourescence experiments. With this new instrument, we will be able to transfer the technology co-developed in Dr. Heyduk's laborato

Trans-NIH Recovery Act Research Support The proposed research will provide essential information in order to move the field of RNA research forward. The data that is collected from this proposed research can be used to better understand humans, bacteria, and viruses and can be utilized by other

Trans-NIH Recovery Act Research Support Epithelial-mesenchymal interactions are required for normal intestinal morphogenesis and have a critical role in epithelial carcinogenesis. The focus of the parent grant is to elucidate the role of mesenchymally derived subepithelial myofibroblasts in med

Trans-NIH Recovery Act Research Support The purpose of this administrative supplement is to provide funding for summer appointments of undergraduate student researchers to work in laboratories of Washington University Diabetes Research Training Center (DRTC) affiliated investigators.

Trans-NIH Recovery Act Research Support DNA helicases are ATP-dependent motor proteins that unwind duplex DNA to form the single stranded (ss) DNA intermediates required for DNA metabolism in all organisms. We are studying the kinetic mechanisms of DNA unwinding and DNA translocation of three n

Trans-NIH Recovery Act Research Support This CLIN supplement proposes four goals that extend studies outlined in the parent grant 'Effects of Asymmetric Hearing in Acoustic Listeners and Cochlear Implant Users'. The premise of the parent grant is that listening with just one ear seriously deg

Trans-NIH Recovery Act Research Support Impaired axonal transport may play an early, pivotal role in a variety of neurodegenerative disorders including Parkinson's disease (PD). When axon transport is disrupted, trophic support is lost, synaptic vesicles and transmitters are depleted, biologica

Trans-NIH Recovery Act Research Support Osteoporosis, resulting from increased bone resorption relative to formation, affects millions of Americans and its prevalence is increasing with the aging population. It is estimated that half of all women over the age of 50 will have an osteoporosis-rel

Trans-NIH Recovery Act Research Support In this application for administrative supplemental funding to grant K01DK078318, no new specific aims are proposed. Instead, we propose a set of expenditures that will greatly accelerate the pace of completion of aims 1d and 3a already described in the

Trans-NIH Recovery Act Research Support Urinary tract infection (UTI) is a common and costly disease that tends to recur in women despite current antibiotic therapies. Recent studies in a mouse model of UTI suggest that some recurrent UTIs are due to an intracellular reservoir of uropathogenic

Trans-NIH Recovery Act Research Support Postoperative morbidity and mortality is an under-recognized, yet significant public health problem. In 2004. 1.4% of all inpatients died after surgery. Myocardial infarction is a major contributor to postoperative mortality. Perioperative (pharmaco-)gene

Trans-NIH Recovery Act Research Support A fully automated cell separator wold allow us to positively isolate F4/80+ cells without manipulation in less than one hour. This technology minimizes cell death and maximizes our ability to isolate pure populations of macrophages so that we can study t

Trans-NIH Recovery Act Research Support Vascular cognitive impairment is highly prevalent, yet its biological basis has not been well studied. The goal of this proposal is to elucidate the molecular and cellular pathological processes underlying retinal vasculopathy with cerebral leukodystrophy

Trans-NIH Recovery Act Research Support Our philosophy is that the most effective way to develop new opportunities in digestive diseases research is to invest in motivated individuals, especially at early stages in their career. This supplement allows us to provide undergraduates with funded r

Trans-NIH Recovery Act Research Support This is an Administrative Supplements (NOT-OD-09-056) for my NIH R15 grant (Application Number: 1 R15 GM086846-01) that was started on December 1, 2008 to study how DME-Interacting Protein 1 regulates demethylation and reproduction in Arabidopsis.

Trans-NIH Recovery Act Research Support The long-term goal of this project is to fully characterize the mechanisms by which neutrophil serine proteases regulate the inflammatory response. We hope that information gained from these studies can be used to develop strategies to inhibit the activit

Trans-NIH Recovery Act Research Support The proliferative function of colonic epithelial progenitors during gut injury is maintained in part through the actions of prostaglandin E2 (PGE2) that is produced in the mesenchyme by Ptgs2. We found that high constitutive levels of Ptgs2 are produced b

Trans-NIH Recovery Act Research Support Matrix metallo-proteinases (MMPs) are often present in high levels in cancer such as tumors of the skin, breast, thyroid, cervix, lung, colon and prostate, but absent in normal tissues. MMPs are enzymes that are capable of chewing through the protein barr

Trans-NIH Recovery Act Research Support Relevance to NIAID mission: This application describes a 5-year training program for the development of an academic career in Pediatric Infectious Diseases, with a goal of independently directing research into parasite biology, pathogenesis, and therapy.

Trans-NIH Recovery Act Research Support The mucosal immune system is a complex network of lymphoid compartments whose function is to protect against invading pathogens. The immune responses generated by the mucosal immune system must be tightly controlled, as inappropriate responses can damage

ARRA - Head Start This award provides ARRA funds for Early Head Start Quality Improvement and Cost of Living Adjustments (COLA) in accordance with FY 2009 Funding guidance ACF-PI-HS-09-06. Early Head Start provides family-centered services for low-income families with ver

Trans-NIH Recovery Act Research Support This supplemental award supports the Accelerating Clinical Trials of Novel Oncologic Path Ways (ACTNOW) program for Protocol ANBL0931, which is a Phase III Study of Chimeric Antibody 14.18 in High-Risk Neuroblastoma. The primary objective of study ANBL09

Trans-NIH Recovery Act Research Support Inclusion body myopathies (IBM) are disabling skeletal muscle disorders and considered a prototypical age related muscle disease. There is no effective treatment. IBM muscle has characteristic 'rimmed vacuoles' and eosinophilic inclusions. These structure

Trans-NIH Recovery Act Research Support The importance and need for continuous metabolites monitoring cannot be overemphasized. Most recent developments for in vivo monitoring devices have focused on miniaturization and the exploratory use of new functional materials. As most biosensors tend to

Trans-NIH Recovery Act Research Support This supplement would provide a modern liquid scintillation counter, a machine that will aid in metabolic measurements, to support an ongoing NIH-funded project. The proposal meets the aims of the ARRA by providing funds that would be rapidly spent on equ

Trans-NIH Recovery Act Research Support Lower Urinary Tract Symptoms(LUTS) due to benign prostatic hyperplasia (BPH) are one ofthe most common disorders ofthe aging male. Over the last decade significant advances have been made in characterizing this abnormality and treating it with medical the

Trans-NIH Recovery Act Research Support The goal of this new R21 proposal is to develop a pro-inflammatory and non-tolerogenic HIV vaccine delivery system based on the dendritic cell targeting anti-DEC-205 antibody. The success of anti-DEC-205 as a stimulator of strong inflammatory immune respo

Trans-NIH Recovery Act Research Support This application describes a 5-year training program for the development of an academic career in Pediatric Infectious Diseases, with a goal of independently directing research into parasite biology, pathogenesis, and therapy. Research design and methods:

Aging Home-Delivered Nutrition Services for States ARRA provided funding for Home-Delivered Nutrition Services. Established in 1978 under the Older Americans Act, the program provides meals to seniors who are homebound.

Trans-NIH Recovery Act Research Support This application is for an administrative supplement for parent grant DK064989, entitled Cellular mechanisms that promote or prevent lipotoxicity. Specifically, funds are being requested for the purchase of a quantitative real-time PCR instrument that wil

ARRA - Communities Putting Prevention to Work: Chronic Disease Self-Manage In collaboration with the Recovery Act-funded Communities Putting Prevention to Work (CPPW) program, this funding will support the deployment of evidence-based chronic disease self-management programs that empower older peoplele with chronic disease to main... Show more

Trans-NIH Recovery Act Research Support The long term goal of this project is to understand the molecular mechanisms responsible for altered glucose homeostasis during highly active antiretroviral therapy (HAART). The metabolic changes that occur in association with the use of HIV protease inhi

Trans-NIH Recovery Act Research Support The purpose of our research is to explain antigen presentation by class II MHC molecules having a strong biochemical, quantitative and mechanistic foundation in order to avoid the many empiricisms that dominate this complex area. We investigated how the m

Trans-NIH Recovery Act Research Support Everyday face-to-face conversations often occur in the presence of adverse environmental conditions such as background noise and/or poor lighting. In this second stage of our research on audiovisual speech perception and aging, we turn our attention to co

ARRA - Immunization ARRA provided funding to stimulate economic recovery and to reduce healthcare costs through prevention activities. These ARRA funds will support the operations needed to deliver and account for those vaccinated.

Trans-NIH Recovery Act Research Support OVERALL PURPOSE: TODAY is a collaborative group funded by the National Instituate of Diabetes and Digestive and Kidney Diseases (NIDDK) to conduct +B20t a clinical trial of therapies in children with type 2 diabetes (T2D). The TODAY study has enrolled 70

Trans-NIH Recovery Act Research Support The primary means by which nerve cells communicate with each other is through the release of neurotransmitter at chemical synapses. The ability of the brain to process information depends on synaptic connections forming precisely and reliably between many

ARRA Child Care and Development Block Grant Improved Access: $30 1/3 Income Disregard The Missouri Child Care Assistance Program served 397 (unduplicated) households through the $30 1/3 Income Disregard program for this quarter. A total of 694 (unduplicated) children were served. The total expend

Trans-NIH Recovery Act Research Support Loss of function mutations of the heparan sulfate proteoglycan gene glypican-3 (GPC3), causes an Xlinked disorder in humans known as Simpson Golabi Behmel syndrome (SGBS), a disorder associated with both pre- and postnatal overgrowth, a predisposition to

Trans-NIH Recovery Act Research Support Our previous work suggests that the protein 'Sunday Driver' (syd) organizes a damage surveillance system in peripheral neurons. In this proposal, we will further test the role of syd in conveying vesicle packages and signaling molecules along axons from t

Trans-NIH Recovery Act Research Support This two-year study will utilize a randomized design with the active interventions running for 18 months. We have 26 active US sites (27 approved sites with one having to drop out due to lack of indirect cost recovery to pay IRB costs). The 26 sites will

Trans-NIH Recovery Act Research Support The overall goal of this grant application is to establish highly efficient HCV 1a replication and growth in immortalized human hepatocytes. For this, we plan to generate a high titer HCV 1a by characterizing virus growth in IHH following different approa

Trans-NIH Recovery Act Research Support The Research Center for Auditory and Vestibular Studies, a P30 Core Center Grant, was established in 2001 to meet the specialized needs of hearing and balance researchers at Washington University and surrounding St. Louis area institutions. The developme

Trans-NIH Recovery Act Research Support The long-term goal of this proposal is to define molecular mechanisms that control synaptic strength. Synapses are dynamic-once formed, neural circuits evolve by the addition and elimination of synaptic connections and the modification of their strength.

Trans-NIH Recovery Act Research Support The study's aim is to develop a bedside assay to detect pulmonary micro-aspirations of gastric contents. Such a test is needed to differentiate between frequent and infrequent aspirators so that interventions can be planned accordingly. A total of 2,200 a

Trans-NIH Recovery Act Research Support This study examines 1800 patients treated at more than 20 centers with expertise in robotic and standard prostate surgery; the patients have been evaluated for quality of life before and after surgery, and for complications, costs, and cancer control. WeG

ARRA - Nurse Faculty Loan Program Nurse Faculty Loan Program is used for making NFLP loans to eligible students and for the costs associated with collection of these loans. Goals-School offers full support requested to cover tuition and fees. Importance-Borrowers must complete advanced nu

Trans-NIH Recovery Act Research Support The mucosal immune system is a complex network of lymphoid compartments whose function is to protect against invading pathogens. The immune responses generated by the mucosal immune system must be tightly controlled, as inappropriate responses can damage

Trans-NIH Recovery Act Research Support Osteoporosis and its associated fractures are a major health problem in the USA today. Risk of osteoporotic fractures is affected by gender, age, family history, and obesity with females being at higher risk than males, older individuals at higher risk th

Trans-NIH Recovery Act Research Support In the parent project, we are developing a second generation of cross-bridged macrocyclic ligands (chelators) for copper-, indium- and gallium-based radiopharmaceuticals for diagnostic imaging and targeted radiotherapy of cancer. We are designing pendant-

Trans-NIH Recovery Act Research Support This supplemental project grant supports a new collaboration between the PI's lab and the lab of Dr. Michael Lovett at Washington University to identify the mutant gene responsible for the cleft lip and cleft palate phneotype in the Twirler mutant mice. B

NOTE: This project was funded on 11/05/09 and began 11/16/09. The A-TEK Team has been awarded the requirement to provide support for the USDA Rural Development (RD) Application, Design, Development, Testing and Helpdesk. The A-TEK Team will support RD

Trans-NIH Recovery Act Research Support The purpose of this Administrative Supplement is to explore a new therapeutic target for globoid cell leukodystrophy (GLD) that was discovered during our NIH-funded research and accelerate the translation of these approaches into the clinic. Consistent w

Trans-NIH Recovery Act Research Support This application addresses broad Challenge Area (05) Comparative Effectiveness Research and specific Topic 05-CA-104* Comparative Effectiveness Research on Cancer Treatment. Effectiveness of prostate cancer treatment has been previously evaluated by Marko

Trans-NIH Recovery Act Research Support Intravenous recombinant tissue plasminogen activator (IV rt-PA) is an effective therapy for acute ischemic stroke but has substantial limitations when used alone to open occluded major extracranial and intracranial arteries. The EMS and IMS I Pilot Studie

Trans-NIH Recovery Act Research Support The Siteman Cancer Center (SCC) Program for the Elimination of Cancer Disparities (PECaD) is a multidisciplinary community-focused program established to eliminate pervasive disparities of cancer education, prevention, and treatment. The SCC Senior Leader

Recovery Act Comparative Effectiveness Research - AHRQ 'In response to RFA-10-003: AHRQ Clinical and Health Outcomes Initiative in Comparative Effectiveness: the goal of this project is to conduct a randomized controlled multi-center clinical trial to determine whether using the Online Wound Electrononic Medica... Show more

Trans-NIH Recovery Act Research Support The prevalence of non-alcoholic fatty liver disease (NAFLD) and its severe phenotype, non-alcoholic steatohepatitis (NASH), are increasing significantly in the United States in the adult and pediatric population. NAFLD is associated with obesity and meta

Trans-NIH Recovery Act Research Support 30% of women suffer from frequent recurrent infections. The goal of this project is to improve understanding of the pathogenic mechanisms underlying UTIs, resulting in new diagnostics and novel approaches to prevention and treatment, more tailored therapi

Trans-NIH Recovery Act Research Support Sepsis is the leading cause of death in intensive care units in the United States, with up to 210,000 people dying from the disease annually. Gut epithelial apoptosis is elevated in both animal models and human autopsy studies of sepsis. We have previousl

Trans-NIH Recovery Act Research Support Chronic kidney disease (CKD) in children is a devastating illness. The prevalence of patients aged 0 ? 19 years with ESRD has grown 32% since 1990 and the mortality rate for children with ESRD receiving dialysis therapy is between 30 and 150 times that o

Trans-NIH Recovery Act Research Support This proposal seeks to continue funding for the TRIGR (Trial to Reduce IDDM in the Genetically at Risk) Data Management Unit (DMU). Established in 2002, the DMU at the University of South Florida was initially funded by a two-year start-up grant from the

Trans-NIH Recovery Act Research Support Chronic kidney disease (CKD) in children is a devastating illness. The prevalence of patients aged 0 ? 19 years with ESRD has grown 32% since 1990 and the mortality rate for children with ESRD receiving dialysis therapy is between 30 and 150 times that o

Trans-NIH Recovery Act Research Support This project investigates the potential of targeting two amino acid transporters, ASCT2 and LAT1, as therapy for human hepatocellular carcinoma (HCC), and to determine their role in HCC development and growth. The incidence of HCC is on the rise in the Un

Trans-NIH Recovery Act Research Support Prion diseases are fatal neurodegenerative disorders of humans and animals. They result from conversion of PrPC, a normal membrane glycoprotein into PrPSc, a conformationally altered isoform that is infectious in the absence of nucleic acid. Most exogenou

Trans-NIH Recovery Act Research Support In year 2 of the grant, we will have identified the ligand which binds to CG4395, synthesized it and raised antibodies to it. We originally planned to develop competitive ELISA assays to do this, using fluorescence detection. However, we recently isolated

Trans-NIH Recovery Act Research Support This supplement is the NORDIC (Neuro-Ophthalmology Research Disease Investigator Consortium) Headquarters portion of a joint effort for both Drs Mark Kupersmith and Karl Kieburtz on behalf of our respective institutions, St. Luke?s Roosevelt Hospital and