Cipro

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Fluoroquinolones, including CIPRO®, are associated
with an increased risk of tendinitis and tendon rupture in all ages. This risk
is further increased in older patients usually over 60 years of age, in
patients taking corticosteroid drugs, and in patients with kidney, heart or
lung transplants (see WARNINGS).

Fluoroquinolones, including CIPRO, may exacerbate
muscle weakness in persons with myasthenia gravis. Avoid CIPRO in patients with
known history of myasthenia gravis (see WARNINGS).

To reduce the development of drug-resistant bacteria and
maintain the effectiveness of CIPRO Tablets and CIPRO Oral Suspension and other antibacterial drugs, CIPRO Tablets and CIPRO Oral Suspension should be used
only to treat or prevent infections that are proven or strongly suspected to be
caused by bacteria.

DRUG DESCRIPTION

CIPRO (ciprofloxacin hydrochloride) Tablets and CIPRO
(ciprofloxacin*) Oral Suspension are synthetic broad spectrum antimicrobial
agents for oral administration. Ciprofloxacin hydrochloride, USP, a
fluoroquinolone, is the monohydrochloride monohydrate salt of
1-cyclopropyl-6-fluoro-1, 4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic
acid. It is a faintly yellowish to light yellow crystalline substance with a
molecular weight of 385.8. Its empirical formula is C17H18FN3O3•HCl•H2O
and its chemical structure is as follows:

Ciprofloxacin is
1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic
acid. Its empirical formula is C17H18FN3O3
and its molecular weight is 331.4. It is a faintly yellowish to light yellow
crystalline substance and its chemical structure is as follows:

Ciprofloxacin Oral Suspension is available in 5% (5 g
ciprofloxacin in 100 mL) and 10% (10 g ciprofloxacin in 100 mL) strengths.
Ciprofloxacin Oral Suspension is a white to slightly yellowish suspension with
strawberry flavor which may contain yellow-orange droplets. It is composed of
ciprofloxacin microcapsules and diluent which are mixed prior to dispensing
(See Instructions for Use/Handling). The components of the
suspension have the following compositions:

What are the precautions when taking ciprofloxacin (Cipro)?

Before taking ciprofloxacin, tell your doctor or pharmacist if you are allergic to it; or to other quinolone antibiotics such as norfloxacin, gemifloxacin, levofloxacin, moxifloxacin, or ofloxacin; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.