Additional notesReconstituted material should be aliquoted and frozen at -20°C. It is recommended that a carrier protein (0.1% HSA or BSA) is added for long term storage.

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Preparation and Storage

Stability and Storage

Shipped at 4°C. Store at -20ºC.

This product is an active protein and may elicit a biological response in vivo, handle with caution.

ReconstitutionCentrifuge vial before opening. It is recommended to reconstitute the lyophilized product with sterile water at a concentration of 0.1mg/mL, which can be further diluted into other aqueous solutions.

General Info

Alternative names

12-O-tetradecanoylphorbol 13-acetate repressed protein 1

AI174028

C-X-C motif chemokine 12

Chemokine (C-X-C motif) ligand 12

Chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1)

Chemokine CXC motif ligand 12

cxcl12

hIRH

hSDF-1

Intercrine reduced in hepatomas

IRH

OTTHUMP00000019491

PBSF

Pre-B cell growth-stimulating factor

SCYB12

SDF 1

SDF-1

SDF-1-alpha(3-67)

SDF-1a

SDF-1b

SDF1_HUMAN

SDF1A

SDF1B

Stromal cell-derived factor 1

Stromal cell-derived factor 1 delta

Stromal cell-derived factor 1 gamma

Stromal cell-derived factor 1a

Stromal cell-derived factor-1 alpha

Thymic lymphoma cell-stimulating factor

Tlsf

TLSF-a

TLSF-b

Tlsfa

Tlsfb

TPAR1

see all

FunctionChemoattractant active on T-lymphocytes, monocytes, but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. SDF-1-beta(3-72) and SDF-1-alpha(3-67) show a reduced chemotactic activity. Binding to cell surface proteoglycans seems to inhibit formation of SDF-1-alpha(3-67) and thus to preserve activity on local sites. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Inhibits CXCR4-mediated infection by T-cell line-adapted HIV-1. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of ACKR3 expressed in various cells. Has several critical functions during embryonic development; required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation.

Tissue specificityIsoform Alpha and isoform Beta are ubiquitously expressed, with highest levels detected in liver, pancreas and spleen. Isoform Gamma is mainly expressed in heart, with weak expression detected in several other tissues. Isoform Delta, isoform Epsilon and isoform Theta have highest expression levels in pancreas, with lower levels detected in heart, kidney, liver and spleen.

Post-translationalmodificationsProcessed forms SDF-1-beta(3-72) and SDF-1-alpha(3-67) are produced after secretion by proteolytic cleavage of isoforms Beta and Alpha, respectively. The N-terminal processing is probably achieved by DPP4. Isoform Alpha is first cleaved at the C-terminus to yield a SDF-1-alpha(1-67) intermediate before being processed at the N-terminus. The C-terminal processing of isoform Alpha is reduced by binding to heparin and, probably, cell surface proteoglycans.