Baclofen for muscle cramps

This leaflet concerns the use of baclofen in severe muscle spasms (spasticity). This may be due to cerebral palsy or other diseases of the brain or spinal cord.

This leaflet has been specially developed for parents and caregivers of children. Our information sometimes differs from manufacturer information as it is usually intended for adult patients. Please read this manual carefully. Store it in a safe place so you can read it again. Do not stop baclofen because it can cause serious side effects.

Name of the drug: Baclofen

Common brands: Baclospas®, Lioresal®, Lyflex®

Why is it important for my child to take this medicine?

Baclofen helps your child's muscles relax. This will help your child to move and facilitate moving and less pain. Baclofen can also help relieve muscle pain.

What is Baclofen available?

Tablets: 10 mg

Liquid medicine: 1 mg in 1 ml

Various tablets or medicaments may contain various ingredients in addition to baclofen. Read the package leaflet or the package leaflet to find out if the medicine contains something your child should not have.

All of the above products must be specially ordered by your pharmacist.

When should I give Baclofen?

You and your doctor will decide when and how often you should give Baclofen to your child.

How much should I give?

Your doctor will determine the appropriate amount of baclofen (the dose) for your child. The dose is indicated on the label of the drug.

They will give your child a small amount and then increase the dose gradually. Your doctor will ask you if the medicine works well and may suggest that you change the amount you are giving or, if so, get the best results. If you think the dose is not correct, talk to your doctor. It is important that you follow your doctor's instructions regarding the amount to be administered.

How should I give it?

Baclofen should be taken with or shortly after meals.

The tablets should be swallowed with a glass of water, fruit juice or similar. Your child should not chew the tablets. Your doctor may have prescribed you a half or a quarter tablet.

Liquid medicines: Measure the appropriate amount with an oral syringe or a medicine spoon. You can get it from your pharmacist. Do not use a teaspoon for the kitchen because it does not give the right amount.

When should the medication work?

Your child's muscles should feel less stiff for 3 to 4 days after regular baclofen use. It may take up to 10 days for the maximum effect to be achieved.

What happens if my child is sick (vomiting)?

If your child is ill less than 30 minutes after taking baclofen, give him the same dose.

If your child is ill for more than 30 minutes after taking baclofen, you do not need to give him another dose. Wait for the next normal dose.

And if I forget to give it?

If you forget to take a dose, your child's muscles may stiffen slightly. Give the dose as soon as you remember. Wait at least 4 hours before administering the next dose.

And if I give too much?

It can be dangerous to give your child too much baclofen. If you think your child has too much baclofen, contact your doctor or take it to the hospital immediately. Tell the doctor that he may have taken too much baclofen. Take the medicine or package with you so the doctor can see what has been taken. Take the packaging with you if you ask for advice.

Are there any possible side effects?

We use medicines to improve our children, but sometimes they have other effects that we do not want (side effects).

Side effects that you need to do something

If your child has a seizure or is very sleepy or has difficulty waking up, it may be too much baclofen. Take her to the hospital immediately.

If your child has breathing difficulties, take him to the hospital immediately.

Tell the doctor that your child is taking baclofen. Take the medicine or the pack with you.

Other side effects that you need to know

If your child is confused, can not sleep, has nightmares, or is anxious or trembling, consult your doctor.

Your child may be sleepier than usual, may feel ill and have urination problems (pee).

Your child may become dizzy when moving from a back to a sitting position. Tell your doctor if this happens because your child may have low blood pressure.

If your child's muscles relax (hypotonic), consult your doctor, as you may need to use less baclofen.

There may be other side effects that are not listed above. If you notice anything unusual and are worried, talk to your doctor.

Do I have anything else about this medication?

If your doctor determines that baclofen is not suitable for your child, you must gradually reduce the dose for a few weeks so that your child has no side effects. Do not reduce the dose without first talking to your doctor.

If your child is already taking other medications, talk to your doctor before starting Baclofen.

Baclofen may not be suitable for children with stomach ulcers, mental health problems or difficulty urinating (peeing). If your child suffers from any of these conditions, consult your doctor.

General information on medicines

If Baclofen does not seem to control your child's cramps, consult your doctor.

Try to administer medication at about the same time each day so you can remember it better.

Give this medicine only to your child. Never give it to a third party, even if his condition seems the same, it could hurt.

If you think someone else accidentally took the medicine, contact your doctor immediately.

Make sure you always have enough medication. Order a new prescription at least 2 weeks before your due date.

Make sure that the medicine you have at home has not reached the expiry date or date stated on the package. Give your old medicine to your pharmacist for disposal.

Where should I keep this medicine?

Keep all medications where children can not see or reach them.

Store this medicine in a cool, dry place away from direct heat and light. It is not necessary to keep it in the fridge.

Store the medicine in the container in which it has entered.

Who to contact for more information

Your doctor or pharmacist can give you more information about baclofen and the relief of pain caused by muscle spasticity.

Baclofen: an effective muscle relaxant

Baclofen is divided into centrally acting muscle relaxants. This class of drugs leads to reduced skeletal muscle tone and relaxation of these muscles. This effect of baclofen is beneficial in cases where muscle spasm is an important feature. These include acute spasms such as sprains, muscle tears (excessive stretch), ligament and tendon tears; and chronic diseases such as multiple sclerosis, spinal cord injury, amyotrophic lateral sclerosis and hemiplegia, paraplegia. Baclofen acts mainly on the spinal cord. For this reason it is classified as a "central" agent.

This is how Baclofen works

Baclofen is a centrally acting muscle relaxant. The structure is similar to the compound GABA (γ-aminobutyric acid), which is an inhibitory neurotransmitter in the brain and spinal cord. Baclofen is selective for the type of GABAB receptor. The main effect of baclofen is in the spinal cord, where it reduces polysynaptic and monosynaptic reflexes. This leads to a decrease in skeletal muscle tone and effectively treats the spasticity seen in conditions such as multiple sclerosis and spinal cord injury. However, baclofen is less effective when used against spasticity that occurs after stroke, trauma or in patients with cerebral palsy.

How to use Baclofen

Baclofen is approved for the treatment of chronic conditions such as muscle spasms and stiffness spasticity such as multiple sclerosis, spinal cord injury, amyotrophic lateral sclerosis, spinal cord tumors and head injuries. Although baclofen is not very effective in acute conditions, it can be used for traumatic muscle spasms, ligament and tendon injuries, and muscle fluctuations. Due to the presence of other muscle relaxants that are better adapted to this purpose, baclofen is rarely used under these conditions. Baclofen can be used as oral or injectable tablets, which should only be used intrathecally. Oral tablets are manufactured in doses of 20 mg and 10 mg. Under the above conditions, baclofen is given three times a day after meals at a dose of 5 mg.

At the beginning of treatment, the dose is increased by 5 mg per dose at 3-day intervals to a final dose of 20 mg, taken three times a day. The maximum permitted baclofen dose is 80 mg / day. In general, patients do not require more than 60 mg / day, and this dosage will provide adequate response. It is recommended to use the lowest effective dose of baclofen as a maintenance dose when needed. Intrathecal administration of baclofen involves the use of a surgically implanted infusion pump and delivery of the drug to the spinal cord, its primary area of action. This approach should be used only in patients who do not respond to the usual oral dosing regimen or who have experienced intolerable side effects of baclofen. Direct administration of baclofen to the spine reduces the frequency of side effects, as the drug has no systemic circulation and much lower doses can be used. The use of baclofen should not be interrupted abruptly, since in these circumstances withdrawal symptoms have been reported.

Precautions and side effects of baclofen

Use of alcohol while taking baclofen is prohibited as alcohol may potentiate its effects. The use of heavy machinery and driving are also discouraged. Baclofen should be used with caution and at lower doses in patients with renal impairment, hepatic dysfunction, urinary difficulties, diabetes mellitus, stroke, and patients with a history of mental illness. Drowsiness, nausea, confusion, dizziness, muscle weakness, tremors, dry mouth, tiredness and fatigue are common side effects of baclofen. The rarer side effects of baclofen include: seizures, urinary retention, impotence, blurred vision and sometimes psychiatric manifestations such as hallucinations.

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