The significant difference in expression of PDLIM5 mRNA in the peripheral blood leukocytes of treatment-naive bipolar (BPD) patients versus that of healthy control subjects suggests that it may be a good biological marker for BPD.

LIM domains have a novel molecular function: the regulation of PKC activities in a PKC isoform-specific manner.

Altered expression of LIM was found in brains and lymphoblastoid cells from patients with bipolar disorder.

It is confirmed a decreased expression of LIM in the lymphoblastoid cell lines from patients with bipolar I disorder and schizophrenia.

Western blot studies of muscle tissues revealed that ENH4 is present only in skeletal muscle and there is a specific distribution of ENH members between skeletal and cardiac muscles, which is different in human and mouse.

ENH is a restraining factor of the oncogenic activity of inhibitor of DNA binding 2 proteins in neural tumors

Our investigation indicates that the lower expression levels of LIM mRNA in the peripheral leukocytes are associated with the depressive state and that its recovery after treatment may be an adaptive change induced by the antidepressant.

We suggest that the higher expression levels of the PDLIM5 mRNA in the peripheral leukocytes may be a candidate marker for medication-free schizophrenic patients.

Mouse (Murine) PDZ and LIM Domain 5 (PDLIM5) interaction partners

Cypher (show LDB3 Proteins) and ENH redundantly play an essential role in sustaining Z-line structure from the earliest stages of cardiac function, and are redundantly required to maintain normal embryonic heart function and embryonic viability.

coordinated and stepwise splicing transitions result in the production of specific ENH transcripts in mature striated (show NSDHL Proteins) muscles.

Deletion of ENH leads to destabilization of this protein complex and dilated cardiomyopathy in mice.

Antagonistic splice variants of enigma (show PDLIM7 Proteins) may play a central role in the adaptive changes of the link between mechanical stress-sensing and signalling occurring during embryonic development and/or heart hypertrophy.

Western blot studies of muscle tissues revealed that ENH4 is present only in skeletal muscle and there is a specific distribution of ENH members between skeletal and cardiac muscles, which is different in human and mouse.

These results identify Enigma as a novel APS-binding protein and suggest that the APS/Enigma complex plays a critical role in actin cytoskeleton organisation.

ENH is a restraining factor of the oncogenic activity of inhibitor of DNA binding 2 proteins in neural tumors

PDZ and LIM Domain 5 (PDLIM5) Protein Profile

Protein Summary

This gene encodes a member of a family of proteins that possess a 100-amino acid PDZ domain at the N terminus and one to three LIM domains at the C-terminus. This family member functions as a scaffold protein that tethers protein kinases to the Z-disk in striated muscles. It is thought to function in cardiomyocyte expansion and in restraining postsynaptic growth of excitatory synapses. Alternative splicing of this gene results in multiple transcript variants.