<underline>A Comparison, Evaluation and Accuracy Assessment of the Fluidigm <super>(TM)</super> Platform in Genotyping Common and Rare variants in an Alaska Native Population</underline> by Joseph Yracheta Pharmacogenomics ...

Bupropion is a norepinephrine and dopamine reuptake inhibitor that is currently indicated for use as an antidepressant (Wellbutrin), a smoking cessation aid (Zyban) and a weight loss therapy in combination with naltrexone ...

Background The global rise in antibiotic resistance has led to an increased need for effective antimicrobial treatments. Polymyxins have re-emerged in recent years due to their strong antimicrobial activity against resistant ...

Background The primary treatment for soft tissue sarcoma (STS) is surgical excision of the tumor. There are variations in the surgical strategies used to excise the tumor. It is unknown which surgical strategy is more ...

Drug transporters play an important role in drug disposition and can be major determinants of drug pharmacokinetics, pharmacodynamics and toxicity. In contrast to drug metabolizing enzymes, which mainly concentrate in the ...

Background. Active surveillance pharmacovigilance (PV) is a systematic approach to medicine safety assessment and health systems strengthening. These systems can better estimate the burden of adverse events (AEs) and can ...

The activity of cytochrome P450 2D6 (CYP2D6) is highly variable due to genetic and environmental influences. Assessing CYP2D6 activity may aid in initial dosing of drugs metabolized by CYP2D6, help maximize therapeutic ...

Background: Many new disease-modifying therapies (DMTs) have recently been approved for relapsing-remitting multiple sclerosis (RRMS) in the United States. Objective: To assess the values of 10 first-line therapies for ...

During pregnancy, physiological and ADMET changes in the maternal-fetal dyad can significantly alter drug pharmacokinetics (PK) in the mother and may necessitate dosing regimen adjustments. One clinically important example ...

Due to the alteration of the physiological functions, the disposition of xenobiotics is often changed under disease conditions and during pregnancy compared with the healthy status. Under disease conditions including chronic ...

Background The utility value is a necessary component of the cost-utility analysis (CUA). They can be obtained from various perspectives and using different methods. The relationship between elicitation methods and ...

Retinoic acid (RA), the active form of vitamin A, is an essential signaling molecule in many tissues and the concentrations of RA are spatiotemporally controlled in target tissues. However, the source of RA in each tissue ...

Objectives: Health economics and outcomes research (HEOR) is a growing field that has gained substantial momentum in recent decades. While studies establishing a product's safety and efficacy have a well-understood role ...