..The profession does require clear, uniform guidelines that are evidence-based. At present, there is still significant debate as to who is at risk from dental-induced bacteremia and what procedures require chemoprophylaxis...

Antibiotic prophylaxis for patients with joint prostheses - still a dilemma for dental practitioners

R A SeymourDepartment of Restorative Dentistry, School of Dental Sciences, University of Newcastle upon Tyne, Framlington Place, NE2 4BWBr Dent J 194:649-53. 2003

..To provide a critical review of the current evidence that implicates dental-induced bacteraemia as a risk for joint infections in patients fitted with joint prostheses and appraise the need for antibiotic prophylaxis...

..The aim of the present study was to evaluate the efficacy of three different surgical techniques in both the management and effect upon rate of overgrowth recurrence of drug-induced gingival overgrowth (DIGO)...

Dentistry and the medically compromised patient

R A SeymourSchool of Dental Sciences, University of Newcastle upon Tyne, Framlington Place, Newcastle upon Tyne NED2 4BWSurgeon 1:207-14. 2003

..Although the association is convincing, casualty has not been established. If casualty for this relationship can be confirmed then the delivery of dental care and the promotion of oral health will receive a significant impetus...

..CRP levels have also been shown to decrease following periodontal therapy. CRP is a reliable marker of the acute phase reaction to infections and/or inflammation and is a powerful predictor of future coronary events...

Incidence and severity of phenytoin-induced gingival overgrowth in epileptic patients in general medical practice

..To evaluate the efficacy of single doses of intravenous diclofenac sodium (25, 50 and 75 mg) in patients with post-operative pain after third-molar surgery in a randomised, placebo-controlled study...

Gingival fibroblasts grown from cyclosporin-treated patients show a reduced production of matrix metalloproteinase-1 (MMP-1) compared with normal gingival fibroblasts, and cyclosporin down-regulates the production of MMP-1 stimulated by pro-inflammatory c

..71). CONCLUSIONS: The results indicate that this method is suitable for large-scale population studies where it also has the advantage of providing a continuous scale of gingival changes for subsequent statistical analysis...

Phenytoin metabolism to 5-(4-hydroxyphenyl)-5-phenylhydantoin (HPPH) in man, cat and rat in vitro and in vivo, and susceptibility to phenytoin-induced gingival overgrowth

..Previously, many of these topics were taught and examined separately. In this article, we would like to share the Newcastle experience of developing a course in human diseases alongside the GDC guidelines...

Risk factors for gingival overgrowth in patients medicated with ciclosporin in the absence of calcium channel blockers

..This study investigates the effect of a range of potential risk factors on the severity of gingival overgrowth in transplant patients medicated with ciclosporin in the absence of any calcium channel blockers...

..The NICE Guidelines on Prophylaxis against Infective Endocarditis were published early this year. In this review, consideration is given to the evidence that the Working Party evaluated in arriving at their recommendations...

Prevalence of gingival overgrowth in transplant patients immunosuppressed with tacrolimus

..This has been shown to improve hyperglycaemic control in diabetics, reduce the prevalence of adverse pregnancy outcomes and improve surrogate markers that may be of benefit in patients suffering from coronary heart disease...

The efficacy of topical hyaluronic acid in the management of oral lichen planus