Data are means ± SD and represent measures of efficacy. The safety and compliance data are described in the text. P values refer to between-treatment differences using repeated-measures general linear model ANOVA adjusted for age, sex, weight, antihyperglycemic agents (A1C, fasting blood glucose, and fasting blood insulin); for age, sex, weight, BMI, lipid-lowering medications (total, LDL, and HDL cholesterol; triglycerides; and hs-CRP); for age, sex, weight, and aspirin use (fibrinogen, vWF, and factor VIII); and for age, sex, weight, and blood pressure medications (SBP and DBP). Percent changes for each variable are based on the calculation for each individual subject’s percent change.