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Manufacturing operations culture, alarming methodologies, process safety management practices, standard operating procedures, and automated control strategies must work in harmony to prevent abnormal performance. As the issue becomes more and more dependent on human and machine integration, new technologies and implementation techniques like advanced procedural automation can be applied, which will greatly affect operational performance. Those who ignore these new advances in computer enabled manual and automated procedural automation will delay their adoption, and incur highly levels of process safety and productivity risk.