Applications/Dilutions

22 kDa. Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Rhesus Monkey (91%).

Packaging, Storage & Formulations

Storage

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Buffer

PBS (pH 7.0), 1.0% BSA and 20% Glycerol

Preservative

0.01% Thimerosal

Purity

Immunogen affinity purified

Alternate Names for ASC/TMS1 Antibody

ASC

ASCMGC10332

CARD5

CARD5TMS

caspase recruitment domain protein 5

Caspase recruitment domain-containing protein 5

hASC

PYCARD

PYD and CARD domain containing

PYD and CARD domain-containing protein

Target of methylation-induced silencing 1

TMS1

TMS-1

TMS1apoptosis-associated speck-like protein containing a CARD

Background

This gene encodes an adaptor protein that is composed of two protein-protein interaction domains: a N-terminal PYRIN-PAAD-DAPIN domain (PYD) and a C-terminal caspase-recruitment domain (CARD). The PYD and CARD domains are members of the six-helix bundle death domain-fold superfamily that mediates assembly of large signaling complexes in the inflammatory and apoptotic signaling pathways via the activation of caspase. In normal cells, this protein is localized to the cytoplasm; however, in cells undergoing apoptosis, it forms ball-like aggregates near the nuclear periphery. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Contact Information

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