Gene Detail

Gene Symbol

TRAF7

Synonyms

CAFDADD | RFWD1 | RNF119

Gene Description

TRAF7, TNF receptor-associated factor 7, E3 ubiquitin protein ligase, acts as an E3 ligase for multiple NF-kappaB pathway members and for p53, and plays a role in regulation of several signaling pathways and in promoting apoptosis (PMID: 23128672, PMID: 22105767). Mutations in TRAF7 are associated with non-NF2 meningiomas (PMID: 23348505).