I have a desktop shortcut ("C:\Program Files\Program1\Program1.exe" -l test1://1.1.1.1:1 -s "My Thing") that opens an application with no issues as all. I want to assign this to a command button on a form but it is not working. I tried the following but receive run-time error 490: Cannot Open Specified File. What am I missing? Any help would be greatly appreciated!

There's basically three ways: Hyperlink, Shell or ShellExecute, each of which gets handled slightly differently and their own caveats. That article describes them. ShellExecute is usually the preferred method, IMO.