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Scientists in the Robia
lab use biochemical and biophysical methods to investigate transporter
conformational changes in order to understand mechanisms of transporter
function and regulation. In particular, we take advantage of methods such as
fluorescence resonance energy transfer (FRET), fluorescence correlation spectroscopy,
fluorescence lifetime analysis, and molecular dynamics simulations to discover how
transporters move and interact with their regulatory partners.

We are particularly interested in SERCA function in the context of human disease, especially heart failure, which is associated with impaired cardiac calcium handling.