HLA DQ Antibody (SPM422) [DyLight 680] Summary

Immunogen

T4-positive CTL clone HG-38

Localization

Cell surface

Specificity

Recognizes a DQ antigen, which is a dimer of 60kDa. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B Lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35kDa. It is encoded by 5 exons; exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. This MAb strongly blocks cytotoxicity activity of T4-positive cytotoxic T cell clones

Isotype

IgG2a Kappa

Clonality

Monoclonal

Host

Mouse

Gene

HLA-DQ

Purity

Protein A or G purified

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Applications/Dilutions

Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage

Store at 4C in the dark.

Buffer

50mM Sodium Borate

Preservative

0.05% Sodium Azide

Purity

Protein A or G purified

Notes

Dylight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for HLA DQ Antibody (SPM422) [DyLight 680]

CD

CELIAC1DQ alpha 1 chain

DC-1 alpha chain

DQ-A1

FLJ27088

FLJ27328

GSE

HLA class II histocompatibility antigen, DQ(W3) alpha chain

HLA-DCA

HLA-DQA

leucocyte antigen DQA1

leukocyte antigen alpha chain

major histocompatibility complex, class II, DQ alpha 1

MGC149527

MHC class II antigen

MHC class II DQA1

MHC class II HLA-D alpha glycoprotein

MHC class II HLA-DQ-alpha-1

MHC class II surface glycoprotein

MHC HLA-DQ alpha

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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