Fusion

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Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:query proteins and first shell of interactors

white nodes:second shell of interactors

Node Content

empty nodes:proteins of unknown 3D structure

filled nodes:some 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

tsaD

tRNA threonylcarbamoyladenosine biosynthesis protein TsaD ; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction (333 aa)

Predicted Functional Partners:

PBAL39_24830

Putative glycoprotease family exported protein (227 aa)

0.951

PBAL39_07115

Phenylalanyl-tRNA synthetase beta subunit (799 aa)

0.799

PBAL39_06896

Uncharacterized protein (188 aa)

0.766

PBAL39_12007

DNA polymerase I (937 aa)

0.754

PBAL39_13707

ABC transporter related protein (209 aa)

0.752

PBAL39_24058

Uncharacterized protein (64 aa)

0.738

dnaG

DNA primase ; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication (668 aa)

0.731

PBAL39_08721

Sec-independent protein translocase protein TatD (255 aa)

0.725

ksgA

S-adenosylmethionine-6-N’, N’-adenosyl(rRNA) dimethyltransferase ; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3’-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (260 aa)

a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1

node2

node1 accession

node2 accession

node1 annotation

node2 annotation

score

PBAL39_06896

PBAL39_08721

PBAL39_06896

PBAL39_08721

Uncharacterized protein

Sec-independent protein translocase protein TatD

0.594

PBAL39_06896

PBAL39_24830

PBAL39_06896

PBAL39_24830

Uncharacterized protein

Putative glycoprotease family exported protein

0.729

PBAL39_06896

ksgA

PBAL39_06896

PBAL39_04728

Uncharacterized protein

S-adenosylmethionine-6-N’, N’-adenosyl(rRNA) dimethyltransferase ; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3’-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits

0.509

PBAL39_06896

tsaD

PBAL39_06896

PBAL39_24063

Uncharacterized protein

tRNA threonylcarbamoyladenosine biosynthesis protein TsaD ; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction

0.766

PBAL39_07115

PBAL39_08721

PBAL39_07115

PBAL39_08721

Phenylalanyl-tRNA synthetase beta subunit

Sec-independent protein translocase protein TatD

0.619

PBAL39_07115

PBAL39_12007

PBAL39_07115

PBAL39_12007

Phenylalanyl-tRNA synthetase beta subunit

DNA polymerase I

0.616

PBAL39_07115

dnaG

PBAL39_07115

PBAL39_09766

Phenylalanyl-tRNA synthetase beta subunit

DNA primase ; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication

0.721

PBAL39_07115

ksgA

PBAL39_07115

PBAL39_04728

Phenylalanyl-tRNA synthetase beta subunit

S-adenosylmethionine-6-N’, N’-adenosyl(rRNA) dimethyltransferase ; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3’-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits

0.597

PBAL39_07115

tsaD

PBAL39_07115

PBAL39_24063

Phenylalanyl-tRNA synthetase beta subunit

tRNA threonylcarbamoyladenosine biosynthesis protein TsaD ; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction

0.799

PBAL39_08721

PBAL39_06896

PBAL39_08721

PBAL39_06896

Sec-independent protein translocase protein TatD

Uncharacterized protein

0.594

PBAL39_08721

PBAL39_07115

PBAL39_08721

PBAL39_07115

Sec-independent protein translocase protein TatD

Phenylalanyl-tRNA synthetase beta subunit

0.619

PBAL39_08721

PBAL39_12007

PBAL39_08721

PBAL39_12007

Sec-independent protein translocase protein TatD

DNA polymerase I

0.479

PBAL39_08721

PBAL39_13707

PBAL39_08721

PBAL39_13707

Sec-independent protein translocase protein TatD

ABC transporter related protein

0.499

PBAL39_08721

ksgA

PBAL39_08721

PBAL39_04728

Sec-independent protein translocase protein TatD

S-adenosylmethionine-6-N’, N’-adenosyl(rRNA) dimethyltransferase ; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3’-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits

0.497

PBAL39_08721

tsaD

PBAL39_08721

PBAL39_24063

Sec-independent protein translocase protein TatD

tRNA threonylcarbamoyladenosine biosynthesis protein TsaD ; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction

0.725

PBAL39_12007

PBAL39_07115

PBAL39_12007

PBAL39_07115

DNA polymerase I

Phenylalanyl-tRNA synthetase beta subunit

0.616

PBAL39_12007

PBAL39_08721

PBAL39_12007

PBAL39_08721

DNA polymerase I

Sec-independent protein translocase protein TatD

0.479

PBAL39_12007

dnaG

PBAL39_12007

PBAL39_09766

DNA polymerase I

DNA primase ; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication

0.620

PBAL39_12007

ksgA

PBAL39_12007

PBAL39_04728

DNA polymerase I

S-adenosylmethionine-6-N’, N’-adenosyl(rRNA) dimethyltransferase ; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3’-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits

0.448

PBAL39_12007

tsaD

PBAL39_12007

PBAL39_24063

DNA polymerase I

tRNA threonylcarbamoyladenosine biosynthesis protein TsaD ; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction

0.754

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Network Stats

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Functional enrichments in your networkNote: some enrichments may be expected here (why?)

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Statistical background

For the above enrichment analysis, the following statistical background is assumed: