At the FASEB summer research conference on "Arf Family GTPases", held in Il Ciocco,
Italy in June, 2007, it became evident to researchers that our understanding of the
family of Arf GTPase activating proteins (ArfGAPs) has grown exponentially in recent
years. A common nomenclature for these genes and proteins will facilitate discovery
of biological functions and possible connections to pathogenesis. Nearly 100 researchers
were contacted to generate a consensus nomenclature for human ArfGAPs. This article
describes the resulting consensus nomenclature and provides a brief description of
each of the 10 subfamilies of 31 human genes encoding proteins containing the ArfGAP
domain.

Critical physiological events throughout the body are controlled by extracellular
signals from neurotransmitters and hormones acting on cell surface receptors. Receptors
transduce these signals to alter intracellular metabolism and cellular responsiveness
through heterotrimeric G protein/second messenger pathways or through small GTP-binding
protein/protein kinase cascades. The mechanisms that control the responsiveness of
target organ G protein-coupled receptors include receptor ph

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Inactivation of serine/threonine kinase 11 (STK11 or LKB1) is common in lung cancer,
and understanding the pathways and phenotypes altered as a consequence will aid the
development of targeted therapeutic strategies. Gene ...

In S. cerevisiae lacking SHR3, amino acid permeases specifically accumulate in membranes
of the endoplasmic reticulum (ER) and fail to be transported to the plasma membrane.
We examined the requirements of transport of the ...