Research Themes

The Cambridge Neuroscience Community

Interests

Matilde is taking advantage of well defined, standardized cross-species paradigms and innovative imaging techniques to precisely characterize patterns of abnormalities within fronto-striatal circuits in OCD patients. Aim of Matilde’s work is to test whether altered connectivity can be found in specific fronto-striatal loops in OCD patients and, crucially, to relate such disconnectivity to objective measures related to the compulsivity construct, such as cognitive flexibility and goal-directed behaviour.