Applications/Dilutions

50.4 kDa. Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Buffer

20mM Tris buffer(pH 8.0) containing 10% glycerol, 1mM DTT

Preservative

No Preservative

Concentration

1 mg/ml

Purity

>90%, by SDS-PAGE

Alternate Names for Recombinant Human BIN1 Protein

AMPH2

Amphiphysin II

Amphiphysin-like protein

AMPHLDKFZp547F068

box dependant MYC interacting protein 1

bridging integrator 1Box-dependent myc-interacting protein 1

MGC10367

myc box-dependent-interacting protein 1

SH3P9

Background

BIN1, also known as SH3P9, is a nucleocytoplasmic adaptor protein, one of which was initially identified as MYC-interacting protein with features of a tumor suppressor. This protein interacts with and inhibits the oncogenic activity of the myc oncoprotein that has a major role in many human cancers. The loss of Bin1 may contribute to growth deregulation in cancer cells in carcinoma of the breast, colon, lung, cervix, prostate and liver. Recombinant human BIN1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

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