Quick and Dirty

Welcome to the RTA Forum!

I haven't seen what the weather forecast for this weekend looks like, but unless they happen to be getting Snow on the far south end of the Sierras, the fastest and simplest route from Las Vegas to San Francisco is:

I-15 to Barstow
CA-58 through Bakersfield to I-5
I-5 to I-580 into the Bay Area.