Browse our anti-NRBF2 (NRBF2) Antibodies

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anti-Nuclear Receptor Binding Factor 2 Antibodies (NRBF2)

On www.antibodies-online.com are 60 Nuclear Receptor Binding Factor 2 (NRBF2) Antibodies from 13 different suppliers available. Additionally we are shipping NRBF2 Proteins (8) and NRBF2 Kits (3) and many more products for this protein. A total of 80 NRBF2 products are currently listed.

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More Antibodies against NRBF2 Interaction Partners

Human Nuclear Receptor Binding Factor 2 (NRBF2) interaction partners

Here we show that a putative fifth subunit, nuclear receptor binding factor 2 (NRBF2), is a tightly bound component of the class III phosphatidylinositol 3-kinase complex I that profoundly affects its activity and architecture. NRBF2 is a homodimer and drives the dimerization of the larger PI3KC3-C1 complex, with implications for the higher-order organization of the preautophagosomal structure.

This study reveals NRBF2 as a critical molecular switch of PtdIns3K and autophagy activation, and its on/off state is precisely controlled by MTORC1 through phosphorylation.

The activation domain, their small size (COPR1, 26.9 kDa; COPR2, 32.4 kDa), and strict dependence on AF-2 for interaction distinguish COPR1 and COPR2 from the SMRT/NCoR (show NCOR1 Antibodies) type of corepressor and may dampen rather than repress NR-mediated gene expression.