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Abstract

Introduction: Endothelial progenitor cells (EPCs) are promising candidates for autologous cell therapy of diabetic wound repair because of their high angiogenic potentials. However, increased EPC apoptosis in diabetes directly limits its clinical success. MicroRNAs are endogenous non-coding RNAs that regulate gene expression at the post-transcriptional level, but their roles in EPC-mediated angiogenesis in diabetes are incompletely understood. We hypothesized that the pro-angiogenic miR-27b inhibits EPC apoptosis and improves wound healing in type 2 diabetes.