WHO Pesticide Residues Series No. 51975 EVALUATIONS OF SOME PESTICIDE RESIDUES IN FOODTHE MONOGRAPHS
The evaluations contained in these monographs were prepared by the
Joint Meeting of the FAO Working Party of Experts on Pesticide
Residues and the WHO Expert Committee on Pesticide Residues that met
in Geneva from 24 November to 3 December 1975. *
World Health Organization
Geneva
1976
* Pesticide Residues in Food: Report of the 1975 Joint Meeting of the
FAO Working Party of Experts on Pesticide Residues and the WHO Expert
Committee on Pesticide Residues, Wld Hlth Org. techn. Rep. Ser., No.
592; FAO Plant Production and Protection Series, No. 1.
These monographs are also issued by the Food and Agriculture
Organization of the United Nations, Rome, as document AGP:1975/M/13.
ISBN 92 4 166505 X
(c) FAO and WHO 1976
CONTENTS
List of Attendees
Introduction
The Monographs
Aldrin/dieldrin*Benomyl*BioresmethrinBromophos*Bromophos-ethyl*sec-ButylamineCarbaryl*Chlordimeform*Chlorobenzilate*Chlorpyrifos*Chlorpyrifos-methylCoumaphos*CyanofenphosCyhexatin*2,4-D*Demeton*Diazinon*Disulfoton*Endosulfan*Endrin*Ethion*Fenthion*Heptachlor*Leptophos*Lindane*Malathion*Methidathion*Methomyl*Monocrotophos*Omethoate*Parathion-methyl*2-Phenylphenol*Phosalone*Quintozene*Thiabendazole*Thiophanate-methyl*Trichlorfon*ANNEX 1 - Recommendations concerning acceptable daily intakes and
residue limits made at the 1975 meeting
ANNEX 2 - Glossary
ANNEX 3 - References
* Addendum
LIST OF ATTENDEES
Members of the FAO Working Party of Experts on Pesticide Residues:
Dr A. F. H. Besemer, Head, Pesticides Division, Plant Protection
Service, Ministry of Agriculture, Wageningen, Netherlands
Dr G. Bressau, Head, Pesticides Unit, Division of Food Chemistry, Max
von Pettenkofer Institute, Federal Health Office, Berlin
Mr F. Bro-Rasmussen, Head, Department of Pesticides and Contaminants,
National Food Institute, Soborg, Denmark (Rapporteur)
Dr K. A. McCully, Chief, Field Sciences Division, Health Protection
Branch, Department of National Health and Welfare, Ottawa, Canada
Mr J. T. Snelson, Pesticides Coordinator, Department of Agriculture,
Canberra, ACT, Australia (Vice-Chairman)
Dr C. Tomizawa, National Institute of Agricultural Sciences,
Nishigahara, Kita-Ku, Tokyo, Japan
Observer invited by FAO:
Dr A. J. Pieters, Chairman, Codex Committee on Pesticide Residues
Members of the WHO Expert Committee on Pesticide Residues:
Dr W. F. Almeida, Director, Division of Animal Biology, Biological
Institute, Sao Paulo, Brazil
Dr V. Benes, Chief, Department of Toxicology and Reference Laboratory,
Institute of Hygiene and Epidemiology, Prague, Czechoslovakia
(Rapporteur)
Dr G. V. Gracheva, All-Union Scientific Institute of Hygiene and
Toxicology of Pesticides, Polymers and Plastics, Kiev, USSR
Professor F. Coulston, Director, Institute of Comparative and Human
Toxicology, Albany Medical College, Union University, Albany, NY, USA
(Chairman)
Professor D. V. Parke, Chairman, Department of Biochemistry,
University of Surrey, Guildford, England
Dr E. Poulsen, Director, Institute of Toxicology, National Food
Institute, Soborg, Denmark
Mr Huai-chou Wang, Institute of Hygiene, Chinese Academy of Medical
Sciences, Peking, China
Secretariat:
Dr R. L. Baron, National Environmental Research Center, Environmental
Protection Agency, Research Triangle Park, NC, USA (Temporary Adviser)
Dr R. Leski, Chemical Residues and Pollution Section, Joint FAO/IAEA
Division of Atomic Energy in Agriculture, International Atomic Energy
Agency, Vienna, Austria
Dr F. C. Lu, Chief, Food Additives, WHO, Geneva, Switzerland (Joint
Secretary)
Mr A. F. Machin, Senior Research Officer, Central Veterinary
Laboratory, Ministry of Agriculture, Weybridge, England (Consultant)
Dr E. Middleton, Food Directorate, Health Protection Branch,
Department of National Health and Welfare, Ottawa, Canada (Temporary
Adviser)
Dr E. E. Turtle, Pesticides Specialist, Plant Protection Service, FAO,
Rome, Italy (Joint Secretary)
Dr G. Vettorazzi, Scientist, Food Additives, WHO, Geneva, Switzerland
INTRODUCTION
A Joint Meeting of the FAO Working Party of Experts on Pesticide
Residues and the WHO Expert Committee on Pesticide Residues was held
in Geneva from 24 November to 3 December 1975. The general
considerations, including the principles adopted for the evaluations
and a summary of the results of evaluations on a number of pesticide
residues, appear in the publication "Report of the 1975 Joint Meeting
of the FAO Working Party of Experts on Pesticide Residues and the WHO
Expert Committee on Pesticide Residues".1 Additional information,
including previously unpublished summaries of data considered by the
Joint Meeting in arriving at recommendations for acceptable daily
intakes, tolerances and methods of analysis, is to be found in this
document.
Many of the compounds considered at this meeting have been previously
evaluated in earlier publications. If only a limited amount of
additional information of these compounds has become available in the
intervening years, only this latter information is summarized in the
pertinent monograph, and reference is made to the previously published
evaluation, which should also be consulted by the reader who wishes to
obtain a complete evaluation of the compound. Such monograph addenda
are indicated by an asterisk in the "Contents", p. iii. If a large
amount of data has became available since the previously published
evaluation, or if the compound was first considered by the Joint
Meeting in 1975, the pertinent monograph is reproduced in its
entirety.
As much relevant information as possible has been included in the
monographs. This has been obtained from the published literature
wherever possible, but other sources of information have also been
used. Early and complete publication of the results of research in
this field is very important, particularly of that part which could
form the basis for estimation of acceptable daily intakes and
appropriate tolerances.
Publication allows the research to be scrutinized and criticized by
scientists from disciplines not necessarily represented at the
meeting. Data contained in unpublished reports, because they may
include more detail than published work, are often acceptable.
However, such reports must be complete and nonconfidential and
indicate authorship.
1 Pesticide residues in food. Report of the 1975 Joint Meeting of the
FAO Working Party of Experts on Pesticide Residues and the WHO Expert
Committee on Pesticide Residues, Wld Hlth Org. techn, Rep, Ser.,
No. [text missing]; FAO Plant Production and Protection Series, No. 1
Two annexes have been included at the end of this series of
monographs. Annex 1 is a reproduction of Annex I in the Report of the
1975 Joint Meeting,1 and gives the recommendations concerning
acceptable daily intakes and residue limits made at the 1975 Meeting.
Annex 3 gives bibliographic references to all previous Reports and
monographs and other publications of a general nature.
NOTE TO THE READER
Any comments on evaluation for acceptable daily intake should be
addressed to:
Food Additives Unit
World Health Organization
Geneva, Switzerland
Any comments on residues in food and their evaluation should be
addressed to:
Plant Protection Service
Plant Production and Protection Division
Food and Agriculture Organization
Rome, Italy