Pumpkin’s cheeks have G’s, so looking at the cast page, from left to right their cheek markings are G U N S H and I guess the Perfect One is supposed to be O’s where she’s blushing. So I guess the eldest sister must have T markings, to spell out GUNSHOT or SHOTGUN if you SHUFFLE them. Suddenly the comic’s title makes a little bit of sense.

I think it’s due to Rusche liking 70s/80s music references (Shotgun Shuffle is a song by KC & the Sunshine Band) and he wanted a comic name that he could get the domain for and didn’t want ${COMIC_NAME}comic.com/net/org but the whole actual name.

I don’t know if the fact that if you shuffle the order of the sisters’ birthmarks you can spell out shotgun is something he decided on immediately or later as a point in that direction as well.