Prince Andrew denies any suspicion of Jeffrey Epstein's behaviour

Britain's Prince Andrew says he never saw nor suspected any sex crimes during the time he spent with US financier Jeffrey Epstein.

Andrew has faced weeks of scrutiny over his friendship with Epstein, who committed suicide in a Manhattan jail cell earlier this month while being held on sex-trafficking charges.

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The Duke of York, who is the second son of Queen Elizabeth, issued a lengthy statement saying he wanted to "clarify the facts" around his relationship with Epstein.

"At no stage during the limited time I spent with him did I see, witness or suspect any behaviour of the sort that subsequently led to his arrest and conviction," Andrew said.

British media including the Daily Mail have published a picture which they said showed Andrew waving goodbye to a woman from inside a Manhattan mansion owned by Epstein.

The Mail said the picture had been taken in 2010, two years after Epstein pleaded guilty to a Florida state felony prostitution charge and registered as a sex offender.

Prince Andrew has denied any knowledge of criminal behavior by his one-time friend Jeffrey Epstein.Image: AP

US court papers have previously shown that Epstein had socialised with Andrew and other high-profile figures including US President Donald Trump and former president Bill Clinton.

Andrew, 59, said it was a "mistake and error" to see Epstein in 2010 after he pleaded guilty to paying a teenage girl for sex.

He said he first met Epstein in 1999, saw him once or twice a year and stayed in a number of his properties.

"His suicide has left many unanswered questions and I acknowledge and sympathise with everyone who has been affected and wants some form of closure," said Andrew.

Jeffrey Epstein signed a new will just two days before his suicide in jail while facing sex charges.Image: AP

"What I thought I knew of him was evidently not the real person, given what we now know."

His statement on Saturday was issued just days after Buckingham Palace issued a statement in which Andrew rejected any suggestion that he participated in the alleged sex crimes that Epstein was accused of.

Epstein first came under investigation in 2005 after police in Palm Beach, Florida, received reports he had sexually abused underage girls in his mansion there.

By 2007, Epstein was facing a potential federal indictment for sexually abusing dozens of girls between 1999 and 2007. Epstein struck a deal, however, to plead guilty in 2008 to the Florida state felony prostitution charge, and register as a sex offender.

Epstein, 66, was arrested on July 6 and pleaded not guilty to federal charges of sex trafficking involving dozens of girls as young as 14.