Use our comprehensive necroptosis guide to

Understand the molecular mechanisms of necroptosis, pyroptosis and ferroptosis

Learn to recognize the distinct hallmarks that define non-apoptotic cell death

Discover useful tips and tricks to differentiate between non-apoptotic cell death types

What is necroptosis?

Necroptosis is a programmed form of necrosis that is dependent on activation of receptor-interacting kinase 3 (RIPK3)1 and the mixed lineage kinase domain-like (MLKL) pseudokinase2. This form of cell death is morphologically distinct from apoptosis, involving membrane rupture and release of cytoplasmic contents.