Joan Rivers, pictured at An Evening With Joan And Melissa Rivers on Jan. 22. Ilya S. Savenok/Getty Images Joan Rivers, pictured at An Evening With Joan And Melissa Rivers on Jan. 22.

Acid-tongued comedienne Joan Rivers, who parlayed her ground-breaking stand-up act into a second career as talk show host, fashion critic and reality show star, died Thursday. She was 81.

The native New Yorker, who became almost as famous for her unapologetic love of plastic surgery as her barbed humor, never recovered after going into cardiac and respiratory arrest Aug. 28.

Rivers was immediately rushed to The Mount Sinai Hospital from an Upper East Side doctor’s office, but her condition only worsened.Joan Rivers and daughter Melissa Rivers at an event at the 92nd Street Y on January 22. Ilya S. Savenok/Getty Images Joan Rivers and daughter Melissa Rivers at an event at the 92nd Street Y on January 22.

She was placed into a medically-induced coma and then life-support before daughter Melissa finally moved Rivers from intensive care into a private room.

Rivers became a pioneer for women in comedy in an era of male domination, and stayed in the spotlight for six decades after finally breaking through the industry’s glass ceiling.