The letter from Time's Up revisited concerns that Weinstein's legal team might have exerted improper influence on Vance, prompting him to not bring sexual assault charges against the movie mogul for a 2015 encounter with Italian model Ambra Battilana.

"There will only be real consequences for abusive behavior when our public officials, sworn to uphold the law, care as much about the rights of the victim as concerns for the accused," reads the letter published on New York Magazines "The Cut" Sunday night.

Time's Up, a legal defense fund fighting sexual harassment and gender inequality, was founded in January by Hollywood celebrities in response to Weinstein and the #MeToo movement.

Its letter calling for an investigation of Vance was endorsed by several prominent actresses on Twitter.

Manhattan District Attorney Cyrus Vance Jr. faces calls for an investigation into the handling of an accusation against Harvey Weinstein. (Seth Wenig/AP)

"TIME'S UP calls on Gov. Andrew Cuomo @NYGovCuomo to open an investigation of NY County DA, Cyrus Vance @manhattanDA, & the DA office to determine why no one prosecuted #HarveyWeinstein for sexual abuse crimes against one of his accusers, Ambra Battilana. #InvestigateVance," Witherspoon wrote.

Anthony Bourdain also joined the effort, tweeting: "Cyrus Vance. Everybody is watching."

In a lengthy statement, Vance spokesman Danny Frost defended the office's work on sex crimes cases.

"We have great admiration for Times Up and for the courageous women and men who have brought about a long-overdue reckoning with decades of intolerable sexual abuse. Our commitment to justice in these cases is unwavering and we welcome the engagement that powerful advocates like Times Up have brought to this work," Frost said.

"The idea that our Office would shrink from the challenge of prosecuting a powerful man is belied by our daily work and unparalleled record of success on behalf of sexual assault survivors."

Vance's handling of the Battilana case was reexamined late last year amid reports on Weinstein's sexual harassment.

Critics noted Weinstein's lawyer, David Boies, donated $10,000 to Vance's reelection campaign in 2015 after the prosecutor chose not to bring charges in the Battiliana case.

Vance insisted the money didn't influence his decision-making and implemented reform of his campaign donation rules.

Women who have accused Harvey Weinstein of sexual harassment and assault

The Battiliana cases also prompted reports of a split between prosecutors and the NYPD sex crimes unit, which thought it had enough evidence to warrant charges against the film producer.

Time's Up's letter said claims of influence by Weinstein were "particularly disturbing."

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"We are concerned that what appears to be the negative relationship between the sex crimes unit of the Manhattan District Attorney's Office and the Special Victims Unit of the NYPD makes it even less likely that victims who have been assaulted by rich or powerful men will be willing to come forward and that their assailants will be prosecuted and convicted," the group wrote.

Vance's office pointed out that prosecutors and police face different burdens of proof.

"From time to time we'll have our disagreements, but we will never allow them to undermine this shared endeavor," Frost said.

Police and prosecutors are separately investigating an allegation that Weinstein raped actress Paz de la Huerta twice in 2010.

She reported the incident to cops in late October.

Last week, Chief of Detectives Robert Boyce said the case is "going very, very well" and that information had been turned over to the grand jury.