This report documents the effort launched by the National Institute of Standards and Technology (NIST) to develop, organize, and convene a workshop on sustainability to promote the adoption and use of sustainable construction and manufacturing and guide NIST in developing a portfolio of programs that are focused on providing the enabling measurement science to key industry stakeholders. The workshop was organized around four cross-cutting themes: (1) measurement science; (2) systems; (3) planning, design, and supply chains; and (4) economic, environmental, and social aspects. Plenary session presentations were commissioned covering each of the four cross-cutting themes. The plenary session presentations set the stage for focused breakout sessions organized around the four cross-cutting themes. The breakout sessions were used to develop a snapshot of the current state-of-the-art in that topic area, as well as identify gaps and research opportunities. Change agents were also identified. The results of the workshop breakout sessions presented herein provide a path forward for key stakeholders. Thus, this report provides the elements of a roadmap useful not only for NIST but for other key industry stakeholders on potential opportunities for their sustainability-related research, development, and deployment efforts. The workshop provided many useful insights for NIST as it moves forward with its portfolio of programs focused on sustainability-related research. The material contained in this report will promote an increased awareness of sustainability-related issues in the construction and manufacturing industries. The report identifies definitional and methodological disconnects and analyzes them from a systems perspective. The report also identifies barriers to the increased use of sustainability-related products and processes in the construction and manufacturing industries and recommends actions for NIST and others to address these barriers.