Antibacterial

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Antibacterial Library

8044 compounds
For cherry-picking
Update: 2016-11

ASINEX has developed a unique compound library for antibacterial research based on the proprietary natural product-like scaffolds that provide great skeletal diversity combined with the presence of polar functional groups and multiple stereogenic centers. For more information, please download >>>

SL#013
Gram Negative Antibacterials

80 compounds
Pre-Plated Set
Release: 2016

ASINEX has created a library of small molecule compounds based on an “iminosugar” scaffold. The selected molecules occupy a very specific physicochemical space of known Gram negative antibiotics. We have also screened this library against 4 selected bacterial pathogens. Several active compounds inhibited >50% of bacterial growth at a given concentration.
Structures are available,"click here"and downlaod "File#1 Signature Libraries.

SL#062
Microbialb-glucuronidase inhibitors

80 compounds
Pre-Plated Set
Release: 2017

In mice models, several potent (sub-mM) inhibitors of bacterial b-glucuronidases have shown that they significantly reduce the GI damage caused by chemotherapeutic agents. Specifically, several qunoline-containing thioureas demonstrated robust selectivity toward bacterial b-glucuronidases over the human enzyme orthologs with accompanying efficacy in vivo. 80 close analogs of the reported inhibitors have been included in this library.
Structures are available,"click here"and downlaod "File#1 Signature Libraries.

SL#068
Bacterial riboswitch inhibitors

80 compounds
Pre-Plated Set
Release: 2017

A group from Merck Research Laboratories published a series of structurally related compounds called “ribocils” – small molecules that target the riboflavin riboswitch. These compounds demonstrate potent antibacterial activity and inhibit riboflavin, flavin mononucleotide and flavin adenine dinucleotide synthesis - essential cofactors of bacterial metabolism. 80 close structural analogs of one of the “ribocils” have been included in this library.
Structures are available,"click here"and downlaod "File#1 Signature Libraries.