Textbook-Integrated Guide to Educational Resources

TIGER

Molecules and Medicine (E. J. Corey, Barbara Czakó, and László Kürti)Robert E. BuntrockLooking for a book on common drugs and pharmaceuticals? On diseases and medical conditions? On pharmacology? In addition, do you need some background in chemistry to handle all of this information? If you want all of this, and in addition want it under one cover, then this is the book for you.Buntrock, Robert E. J. Chem. Educ.2008, 85, 1495.

Bioorganic Chemistry |

Drugs / Pharmaceuticals |

Molecular Properties / Structure |

Proteins / Peptides |

Synthesis |

Toxicology

Structures for the ABO(H) Blood Group: Which Textbook Is Correct?John M. RisleySix textbooks and two Internet sites show different structures for the A, B, and O(H) antigens of the ABO(H) blood group, but none of them are correct. This article emphasizes the correct molecular structures because it is important to distinguish between those carbohydrates that make up the antigens and those that are not part of the antigenic structures.Risley, John M. J. Chem. Educ.2007, 84, 1546.

Bioorganic Chemistry |

Carbohydrates |

Natural Products |

Molecular Properties / Structure

The A1c Blood Test: An Illustration of Principles from General and Organic ChemistryRobert C. KerberThe glycated hemoglobin blood test is a key measure of the effectiveness of glucose control in diabetics. The chemistry of glucose in the bloodstream, which underlies the test and its impact, provides an illustration of the importance of chemical equilibrium and kinetics to a major health problem.Kerber, Robert C. . J. Chem. Educ.2007, 84, 1541.

Nature's Way To Make the LantibioticsHeather A. Relyea and Wilfred A. van der DonkThis article focuses on one class of antimicrobial compounds, the lantibiotics, and discusses their biosynthetic pathways as well as their molecular mode of action. In the course of the review, the meaning of the terms regio-, chemo-, and stereoselectivity are discussed.Relyea, Heather A.; van der Donk, Wilfred A. J. Chem. Educ.2006, 83, 1769.

Applications of Chemistry |

Bioorganic Chemistry |

Biotechnology |

Biosynthesis |

Catalysis |

Drugs / Pharmaceuticals |

Proteins / Peptides

Molecular Model of Creatine SynthesisWilliam F. ColemanThe Featured Molecules for this month come from the synthesis of creatine and illustrate some of the limitations associated with the computation of molecular structure. Coleman, William F. J. Chem. Educ.2006, 83, 1657.

(Strept)Avidin–Biotin: Two Interrelated Experiments for the Introductory Chemistry LaboratoryDavid E. Hansen, Dengda Tang, Jon A. Sanborn, and Mark D. MarshallDescribes a two-experiment sequence focusing on the noncovalent complex between the egg white protein avidin (or the similar protein streptavidin, which is expressed by the bacterium Streptomyces avidinii) and the essential cofactor biotin. The equilibrium constant for the binding of HABA to avidin is calculated from the data collected.Hansen, David E.; Tang, Dengda; Sanborn, Jon A.; Marshall, Mark D. J. Chem. Educ.2006, 83, 777.

Bioorganic Chemistry |

Computational Chemistry |

Equilibrium |

Titration / Volumetric Analysis

The Discovery and Development of CisplatinRebecca A. Alderden, Matthew D. Hall, and Trevor W. HambleyCisplatin is currently one of the most widely used anticancer drugs in the world. The unlikely events surrounding the discovery of its anticancer activity, subsequent introduction into the clinic, and the continuing research into platinum compounds is the subject of this review.Alderden, Rebecca A.; Hall, Matthew D.; Hambley, Trevor W. J. Chem. Educ.2006, 83, 728.

A Chemical-Medical Mystery: Gold Jewelry and Black Marks on SkinBarbara B. KebbekusGold jewelry at times makes a black mark or smudge on skin. This may be caused by abrasive powders on the skin (e.g. zinc oxide) but the phenomenon may also be caused by other skin conditions, possibly the presence of chloride ion, acidity, or sulfur-containing amino acids.Kebbekus, Barbara B. J. Chem. Educ.2000, 77, 1298.

Bioorganic Chemistry |

Geochemistry |

Hormones |

Metals |

Solids |

Applications of Chemistry

Two Faces of AlkaloidsJirí DostálThe article discusses and compares the salts and free bases of six well-known alkaloids: nicotine, morphine, cocaine, sanguinarine, allocryptopine, and magnoflorine. Relevance for the biological and medical uses of these compounds is emphasized. Dostál, Jirí. J. Chem. Educ.2000, 77, 993.

Iron as Nutrient and PoisonN. M. Senozan and M. P. ChristianoIron containing compounds of the body and the ingestion and elimination of iron, the function and transport of this metal among different sites and substances of the body, and biochemical defects and nutritional habits that lead to excessive accumulation of iron and some unexpected consequences of this accumulation are described.Senozan, N. M.; Christiano, M. P. J. Chem. Educ.1997, 74, 1060.

Bioinorganic Chemistry |

Bioorganic Chemistry |

Food Science |

Metals |

Vitamins |

Toxicology |

Nutrition |

Applications of Chemistry |

Descriptive Chemistry

Global Metabolism of Elements: Principles and Applications in Bioinorganic Chemistry - XIEi-Ichiro OchiaiThe biosphere, as its members metabolize the elements, can thus contribute to the overall global geocycling of elements. A diagram is used to indicate several different manners of the contribution and their extents of contribution to the geoprocesses. This overall process incorporating the effects of the biosphere is termed here as "global metabolism" and is illustrated for iron, mercury and arsenic. Ochiai, Ei-Ichiro. J. Chem. Educ.1997, 74, 926.

Bioinorganic Chemistry |

Geochemistry

Elements of General, Organic, and Biological Chemistry, Ninth Editionreviewed by John GanchoffThe audience for this text includes students in the health sciences (other than physicians) and nonscience students with an interest in the molecular nature of matter. The text can be used for a one-term course and does not have any chemistry prerequisites. Ganchoff, John. J. Chem. Educ.1996, 73, A135.

Teaching the skills of science - gold and anemiaMattson, WilliamA student poses a question that leads to classroom inquiry: Why does gold rubbed on the face of an anemic person leave a dark mark?Mattson, William J. Chem. Educ.1988, 65, 1000.