Abstract

Background

Latent membrane protein (LMP) 1 and LMP2A encoded by Epstein-Barr virus (EBV) are
associated with the development of malignancies, but their expression in extranodal
NK/T-cell lymphoma, nasal type (ENKTL) and the relationship with clinical characteristics
of this disease remain poorly understood. In the present study, we examined the expression
of LMP1 and LMP2A in ENKTL, and investigated the correlations between LMP1 and LMP2A
expression with clinicopathological characteristics of ENKTL patients.

Methods

Paraffin sections of surgically removed samples from 16 ENKTL patients were analyzed
by immunohistochemistry and the related clinicopathological data were collected and
analyzed.