Opponents cited studies that have shown legalization leads to an increase in the number of children who have access to marijuana. They also point to big business groups that have cashed in on the newly legal marijuana market, equating those businesses with Big Tobacco firms.

Organizers have won ballot campaigns to legalize marijuana in all but one state where those measures have gone before voters. Legalization supporters plan to return to Ohio, the only state where a legalization measure failed, in 2019.