In 2003, introduced by Isaac Green of Columbia records, Rossomando met Carl Barât in NYC and agreed to fill in for Doherty in an upcoming US tour for The Libertines; this was followed by a trip to London to play Top of the Pops and Reading and Leeds festival. Eight months later he rejoined The Libertines to help support the entire worldwide touring campaign for their self-titled second album. It was during this time when Rossomando and Barat began to formulate their ideas that would later embody Dirty Pretty Things. During this time, Rossomando moved from a derelict house in Boston to Central London.

In May 2006, Dirty Pretty Things released Waterloo To Anywhere which reached No. 3 in the UK charts, while the first single "Bang Bang You're Dead", peaked at No. 4. The band toured extensively in the UK, US, Europe and Japan.

Anthony also played trumpet on: • Chisel - "Set You Free" (trumpet) • Piebald - "We Are The Only Friends We Have" • The Cribs - "The New Fellas"

"Rime Of the Modern Mariner", Anthonys first film score, premiered at the East London Film Festival in May 2011 with live orchestral arrangement which also went to several festivals including Lattitude, SXSW, and Toronto. The film and score received high praise from many publications including the Times and the Guardian.

In November 2007, he played the role of Pete Neon in the first episode of the third series of The Mighty Boosh. He was also featured in the documentary The Mighty Boosh: A Journey Through Time and Space, which aired on BBC Three on March 22, 2008.