Zhou Mi was born in Wuhan, China, and studied Broadcasting at Beijing Normal University Zhuhai Campus.[2] During high school, Zhou Mi started to enter national singing and entertainment competitions, winning many of them.[3]

Zhou Mi made a name for himself in the Chinese entertainment scene by competing in competitions.[4] While in contentions for the final round of CCTV’s Challenging the Host, a televised national competition for aspiring MCs from all over China he received an offer from SM Entertainment and decided to go to Korea, in late 2006.[5] Zhou Mi won the grand prize at the SM UCC Star Audition,[6] through an online audition, and joined Super Junior-M, Super Junior's third official sub-unit

In February, Zhou Mi became a new member of the ballad group SM The Ballad, initially formed by SM Entertainment in 2010. On the group's 2nd album, Breath, he sang a Chinese version of "Blind".[11][12] At the end of 2014 he released a solo mini album Rewind.[13]