The use of e-cigarettes among youths has reached epidemic proportions in the United States.1 Juul is the most popular brand of e-cigarettes among youth, and it has been criticized for marketing that targets youths.2 Concerns of serious short-term and long-term health outcomes from e-cigarette use have led to actions from the US Food and Drug Administration, states, and municipalities to ban or restrict the sale of e-cigarettes.3,4 For policies to be effective in curtailing the use of Juul among youth, there must be a greater understanding of youths’ knowledge, beliefs, and motivations regarding this product. This study assesses the perspectives of a national sample of youths on the use of Juul (also known as juuling).