Renvela

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Renvela

DRUG DESCRIPTION

The active ingredient in Renvela is sevelamer carbonate, a polymeric amine
that binds phosphate and is meant for oral administration. It was developed
as a pharmaceutical alternative to sevelamer hydrochloride (Renagel®). Sevelamer
carbonate is an anion exchange resin, with the same polymeric structure as sevelamer
hydrochloride, in which carbonate replaces chloride as the counterion. While
the counterions differ for the two salts, the polymer itself, the active moiety
involved in phosphate binding, is the same.

Renvela (sevelamer carbonate) is known chemically as poly(allylamine-co-N,N'-diallyl199
1,3-diamino-2-hydroxypropane) carbonate salt. Sevelamer carbonate is hygroscopic,
but insoluble in water. The structure is represented in Figure 1.

What are the precautions when taking sevelamer carbonate (Renvela)?

Before taking sevelamer, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: low blood phosphorus levels, bowel blockage.