epithelialize ep·i·the·li·al·ize (ěp'ə-thē'lē-ə-līz') or ep·i·the·lize (-thē'līz)v.ep·i·the·li·al·ized or ep·i·the·lized, ep·i·the·li·al·iz·ing or ep·i·the·liz·ing, ep·i·the·li·al·iz·es or ep·i·the·liz·es To become covered with epithelial tissue, as of a wound.