I believe that high-end graphic games tend to lag as .CSO / compressed iso's. Like god of war or Dante's inferno. I'm fairly sure that strategy RPG's like Disgaea work fine as .CSO's, but don't quote me on that.

This is too difficult a question for a definative answer, as their are simply too many variables.

1) Memory card - I use a CR5400, two 16GB Sandisk micro SD - I have found this to be very quick compared to most standard cards

2) Firmware - I am still on M33-6 (just because of the speed up option)

I have found that very few games have a lag wih my PSP, but change the firmware (I went to Gen D2 at the time) and nearly every game had some lag.
I play GTA and get the odd moment of lag, however I have tried it with the .iso and still had lags when on D2.

I believe that high-end graphic games tend to lag as .CSO / compressed iso's. Like god of war or Dante's inferno. I'm fairly sure that strategy RPG's like Disgaea work fine as .CSO's, but don't quote me on that.

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No, i dont have a problem with God of War and Dante's Inferno using clock-speed 266/133 to save the battery. I am using .iso.. Not .COS's at all. I also have Dante's Inferno encryption version only. No problem so far.

Yeah as dib said Dante's Inferno is pretty much the only game I have had major issues with. The load times were massive and the game would just get stuck randomly on the loading screens forever. Apart from that I have had no real issues with any other cso's.