DeltaNet

A network analysis method for predicting the genetic perturbations caused by a drug or chemical compound using gene expression profiles. DeltaNet is also based on an ordinary differential equation (ODE) model of the gene regulatory network (GRN), but does not require a separate step of GRN inference. Instead, the target predictions are obtained directly from the data, while the GRN is only inferred implicitly. DeltaNet relies on the least angle regression (LAR) and the LASSO regularization to tackle the curse of dimensionality of the underlying regression problem. The method requires little to no expert supervision, while providing accurate gene target predictions.