provide an insight into a model for swapping ATG5 partners for autophagosome maturation

the crystal structures of human ATG5 in complex with an N-terminal domain of ATG16L1 (show ATG16L1 ELISA Kits) as well as an internal AIR domain of TECPR1 (show TECPR1 ELISA Kits), are reported.

Taken together, the results demonstrate that ATG5 cleavage provokes apoptosis and represents a molecular link between autophagy and apoptosis

Increased frequencies of rare variants of ATG5 were identified in patients with LN and Systemic Lupus Erythematosus compared with healthy controls, highlighting a likely important role of rare ATG5 variants in Chinese SLE patients.

Increased expression of ATG5 was significantly correlated with poor overall survival and chemoresistance in gastric cancer.

Data show that the autophagy-related 5 protein (Atg5)-independent autophagy is crucial for establishing pluripotency.

ATG5 plays a unique role in protection against M. tuberculosis by preventing PMN-mediated immunopathology; and while Atg5 is dispensable in alveolar macrophages during M. tuberculosis infection, loss of Atg5 in PMNs can sensitize mice to M. tuberculosis

ATG5 Antigen Profile

Antigen Summary

Required for autophagy. Conjugates to ATG12 and associates with isolation membrane to form cup-shaped isolation membrane and autophagosome. The conjugate detaches from the membrane immediately before or after autophagosome formation is completed (By similarity).

Gene names and symbols associated with ATG5

Autophagy-specific gene 5 (Atg5) antibody

autophagy related 5 (atg5) antibody

APG5 autophagy 5-like (LOC100227318) antibody

APG5 autophagy 5-like (LOC100342807) antibody

ATG5 autophagy related 5 homolog (S. cerevisiae) (atg5) antibody

ATG5 autophagy related 5 homolog (S. cerevisiae) (ATG5) antibody

autophagy protein 5 (APG5) antibody

autophagy related 5 (ATG5) antibody

autophagy related 5 (Atg5) antibody

similar to S. cerevisiae ATG5 (YPL149W) which nucleates preautophagosome formation as a conjugate with Atg12 (ATG5) antibody