HIV+ : Gay & Black Glossary

carrying the HIV (Human Immuno-deficiency Virus)
in the bloodstream. HIV
is believed to be the major cause of AIDS (Acquired Immunodeficiency Syndrome). When you get
a positive result on your HIV
test, it is not something to celebrate, since it means you are infected. HIV
is passed most commonly by screwing/being screwed without a condom or via needles. Very rarely it is passed by
oral sex and only then when there are bleeding gums. The following map distorts the size of countries relative to
how prevalent HIV
is there. It seems the more a country denies it has a problem, the bigger the problem actually is.

HIVDrug Immunity

I have had HIV
since 1985. Every few years my personal strain of HIV
develops an immunity to the drugs that I am taking and I have to flip to a new cocktail of 3 or so drugs. The theory is it should be much harder for my personal strain of
HIV
to simultaneously evolve resistance to three drugs than to one. But they do it! Doctors refer to the drugs as
chemotherapy. The drugs tend to have nasty side effects such as nausea, diarrhoea,
low energy, neuropathy, nightmares and death (abacavir allergy). So it is quite a trick to find a combination
that I can tolerate. The process is not always successful.

Genetic sequencing has greatly improved the process of finding a good combo. Everyone in BC with
HIV
has had their personal strain of HIV
repeatedly genetically sequenced and all its mutations mapped. The mutation map is a nucleotide number followed
by a letter for the freak nucleotide. From this map, they know which mutations give resistance to what degree to
all the various drugs. So they can tell which drugs will fail even if I have never tried them. There are roughly
half a dozen families of drugs. If your personal strain evolves immunity to one drug in a family, it will likely
already be resistant (or soon will be resistant) to the others in the family. There must be thousands and
thousands of mutations for my strain to fluke out and find a way around almost the entire
HIV
pharmacopoeia.

I am in an awkward position in that there is no suitable drug cocktail left. I am awaiting the release of a
new drug (dolutegravir) to fill in the third drug of the cocktail. In the meantime I am not taking any drugs,
least I aid the HIV
to develop immunity to the still-useful drugs in an incomplete cocktail.

Danes have been working on an HIV
cure, where they trick the HIV
to come out of hiding deep inside cells. Then it can be completely eradicated by the patient’s immune
system. I have to hang in there until that works out.

Scientists have developed genetic scissors that are able to enter every cell and snip out the
HIV. This is a cure not just a
treatment. So far it has only been tested in mice. source.

I want to whack creationists over the head with an umbrella when they assure me animals of any sort never
evolve. Tell that to my amazingly capable personal strain of HIV
evolutionists! I have to admire their evolving/computing power, even if they are trying to kill me.

Don’t Miss A Dose

Doctors tell HIV patients that is it extremely
important never to miss a dose of your HIV medication,
but they don’t explain why. Here is my Darwinian explanation:

Let us say there is zero drug X in your body. Some of your HIV
might spontaneously develop an immunity to it, but they have no advantage. There is probably a slight
disadvantage to the mutation. So the strain quickly dies out.

Let’s say you have a therapeutic dose of X in your body. If some of your HIV
develop 25% immunity to it, they are killed off anyway, and the strain quickly dies
out.

Let’s say you have skipped a dose of X and you have only a 10% dose in your
body, if some of your HIV
evolve 25% immunity to it, many of them will thrive and perhaps later develop
50% and 100% immunity. In this case you have produced an
efficient gradient favouring HIV with immunity. This means drug
X will soon lose its effectiveness.

Let’s say you have a cocktail of three drugs. If HIV
evolves immunity to one of the drugs, the other two can still kill off the strain. However, if you skip a dose,
it can reproduce and the mutation can get a toehold.

Tips

HIV buries its genetic code in your helper T cell DNA (Deoxyribonucleic Acid). It reproduces as a side effect of your helper T cells dividing.
This is why it is so important to avoid an sort of unrelated infection, e.g. flu. Helper T cells start reproducing
like mad to fight the flu, and as a side effect flood your body with HIV viruses.

San Francisco is not in the top ten American cities in new HIV infections. They provide education campaigns, free condoms and
clean needles.

55%
of new HIV cases are female. So much for HIV being a gay-only disease.

By far the most new HIV cases in the USA are young black females. They are still living under the delusion they are immune.

Mosquitos do not transmit HIV because they digest the HIV virus particles.

The more promiscuous you are, the more virulent HIV evolves. The more monogamous you are, the milder HIV evolves.
This is simply a mathematical consequence of HIV going for the most infections.