I am very sorry to hear about your wife. I am presuming you are in the US as she has had a diagnosis of phpt and will go ahead with the operation. I cannot imagine Prolia causing the parathryoid glands to overwork. The surgeon who is performing the operation should know but if you are in the UK, that's a different matter. Sadly there is a lot of ignorance about this here. I am surprised, even shocked to learn she was given Prolia with osteopenia. I presume you know that the FDA gave out a warning in January 2017 that if left off, can cause rapid bone loss which can lead to rebound fractures.

I am sorry I cannot answer your question but it might be worth contacting Dr Larian who is an expert in phpt and resides in LA or perhaps Dr Norman at the NPC in Florida.

Although the parathyroids are nothing to do with the thyroid, I have heard several people complain that after a parathryoidectomy it has messed up their thryoid. Maybe check it out and see if she has become hypothryoid which would make your wife feel very tired or even check for peroxidase antibodies to see if she has Hashimotos. I have that and I feel exhausted most of the time. Some endocrinologist just look at the TSH and T4 and say oh yes within the normal range. I had a very expensive private endo in London who was totally useless, I thought I was going mad with terrible symptoms for 13 weeks but my TSH and T4 and T3 were "within the normal range" (one of the most hated medical expressions in the UK at least) but it never occurred to her to check my antibodies which were done latterly by another person and they were over >1300 (normal range is 0 - 60). Good luck

Thanks for your comments. She was diagnosed as hypothyroid about 23 yrs ago. She does take Synthroid each morning and her labs reflect an acceptable A1C. She only came down with the fatigue problem about seven months ago. I will ask about the antibodies testing. That is an interesting approach we had not considered!

I think there is way too much about Prolia that they just don't know. It has not been studied very long. After 3 injections I have Osteonecrosis of the jaw bone. It has been 9 months and sizable amounts of dental bills. It appears possibly still active, and may exist the rest of my life - they just don't know! I currently worry about the rebound effect from going off Prolia. Other drugs were considered, but because of my jaw condition they are reluctant. I'm having hip replacement surgery next Friday, and praying I don't fracture.

Very sorry to hear that and yes you are right about Prolia being evil. Amgen have now brought out another new drug recently approved by the FDA Evenity. It sounds equally as lethal and can cause heartaches and strokes.

Everything is about power and money. I believe Merck still have many outstanding law suits for the damage Fosimax had. Now their license has expired even more companies jumping on the bandwagon with bisphosphonates.

Prolia and all other bones meds. should be taken off the market. I'm so sorry your wife is having to go through this, and do not understand why her doctor felt the need to get her on this crap for osteopenia! Just ridiculous! She needs to stop it immediately, but she will have to go on another kind of bone med. to eliminate the risk of rebound fractures, and hopefully that will work. Gads! This drives me crazy!!!