Native Human Superoxide Dismutase

Cat No.

NATE-0680

Description

Superoxide dismutase (SOD) catalyzes the dismutation of superoxide radicals to hydrogen peroxide and molecular oxygen. SOD plays a critical role in the defense of cells against the toxic effects of oxygen radicals. SOD competes with nitric oxide (NO) for superoxide anion (which reacts with NO to form peroxynitrite), thereby SOD promotes the activity of NO. SOD has also been shown to suppress apoptosis in cultured rat ovarian follicles, neural cell lines, and transgenic mice by preventing the conversion of NO to peroxynitrate, an inducer of apoptosis.

Abbr

SOD, Native (Human)

Alias

SOD; SODF; SOD-1

Source

Human erythrocytes

Species

Human

Applications

Superoxide dismutase from human erythr ocytes has been used in a study to identify in vitro glycated sites of human Cu-Zn-superoxide dismutase. Superoxide dismutase from human erythr ocytes has also been used in a study to investigate a prospective test-system for the screening of cytoprotective drugs and their combinations.

Form

Lyophilized powder containing potassium phosphate buffer salts

Enzyme Commission Number

EC 1.15.1.1

Activity

> 2,500 units/mg protein

CAS No.

9054-89-1

Unit Definition

One unit will inhibit reduction of Cytochrome c by 50% in a coupled system with xanthine oxidase at pH 7.8 at 25°C in a 3.0 mL reaction volume. Xanthine oxidase concentration should produce an initial ΔA550 of 0.025 ± 0.005 per min.