Phenargan
msds (material safety sheet)

Phenargan
Synthesis Reference

Phenargan
Molecular Weight

Phenargan
Melting Point

Phenargan
H2O Solubility

Phenargan
State

Phenargan
LogP

4.946

Phenargan
Dosage Forms

Tablet; Suppository; Opthalmic drops; Syrup

Phenargan
Indication

For the treatment of allergic disorders, itching, nausea and vomiting.

Phenargan
Pharmacology

Promethazine, a phenothiazine, is an H1-antagonist with anticholinergic, sedative, and antiemetic effects and some local anesthetic properties. Promethazine is used as an antiemetic or to prevent motion sickness.

Phenargan
Absorption

On average, 88% of a promethazine dose is absorbed after oral administration; however, the absolute bioavailability is only 25% because of first-pass clearance.

Phenargan
side effects and Toxicity

Symptoms of overdose include mild depression of the central nervous system and cardiovascular system to profound hypotension, respiratory depression, unconsciousness, and sudden death. Other reported reactions include hyperreflexia, hypertonia, ataxia, athetosis, and extensor-plantar reflexes (Babinski reflex). LD50=55mg/kg (I.V. in mice)