Objective To study the clinical effect of Xiaoke pill as adjunctive therapy in patients with poor control of type 2 diabetes mellitus by oral Western medicine. Methods 80 patients with poor control of type 2 diabetes mellitus by oral Western medicine in our hospital from January 2011 to May 2012 were randomly divided into the control group and the observation group, and 40 cases in each group. The control group was treated with gliclazide by oral administration, 80mg per time, 2 times/d. The observation group was treated with Xiaoke pill by oral administration based on the basic treatment of control group, 5 to 10 capsules per time, and 3 times/d. The two groups were all treated with 12 weeks. The total effective rates at 8th and 12th week after the treatment and fasting blood-glucose(FBG),2h postprandial blood glucose(2hPG),glycosylated hemoglobin(HbA1c),fasting insulin(FINS) and 2h postprandial insulin(2hINS) before the treatment and at 8th and 12th week after the treatment of two groups were observed and compared. Results The total effective rates of the observation group at 8th and 12th week after the treatment were higher than those of control group(P<0.05). The FBG,2hPG,HbA1c,FINS and 2hINS at 8th and 12th week after the treatment were all lower than those of control group(P<0.05). Conclusion The clinical effect of Xiaoke pill as adjunctive therapy in patients with poor control of type 2 diabetes mellitus by oral Western medicine is better, and it can effectively control the blood glucose of patients.

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