anti-Vpr (HIV-1) Binding Protein (VPRBP) Antibodies

Component of the Cul4a-Rbx1-Ddb1-Vprbp/Dcaf1 E3 ubiquitin-protein ligase complex, Vprbp/Dcaf1 may function as the substrate recognition module within this complex (By similarity). Additionally we are shipping and many more products for this protein.

The identification of Vpr mutants which associate with DCAF1 but only poorly with DDB1 (show DDB1 Antibodies) suggests that DCAF1 is necessary but is not sufficient for the Vpr association with DDB1 (show DDB1 Antibodies)-containing E3 ligase complex.

VPRBP Antigen Profile

Protein Summary

Component of the Cul4a-Rbx1-Ddb1-Vprbp/Dcaf1 E3 ubiquitin-protein ligase complex, Vprbp/Dcaf1 may function as the substrate recognition module within this complex (By similarity). Associated with chromatin in a Ddb1-independent and cell cycle- dependent manner, Vprbp/Dcaf1 is recruited to chromatin as DNA is being replicated and is released from chromatin before mitosis (By similarity).