1Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States, 2Neurological Surgery, University of California San Francisco, San Francisco, CA, United States, 3Department of Clinical Pharmacy, University of California San Francisco, San Francisco, CA, United States

Dynamic
13C data were acquired following injection of hyperpolarized [1-13C]pyruvate
from 3 patients previously diagnosed with glioblastoma. Pyruvate, lactate and
bicarbonate signal with high SNR were detected in human brain. Lactate/Pyruvate
appeared to be relatively high in the contra-lateral, normal appearing brain.
In contrast, tumor regions produced higher Lactate/Bicarbonate than
contra-lateral brain. The contrast-enhancing lesion of one patient, who
underwent surgical resection shortly after 13C imaging due to
suspected recurrence, produced a relatively low level of Lactate/Pyruvate
compared to contra-lateral brain and Lactate/Bicarbonate similar to the value
in contra-lateral brain. Subsequent biopsy of the contrast-enhancing lesion
indicated treatment effect.

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