Depending on the severity of the disease and the susceptibility of the patient, the initial dose usually is 3-4.5mgdaily, and up to 6-9mg in severe asthma bronchiale, divided in 4 oral doses, or give intramuscularly in one dose.

As soon as a good response is noted the daily dosage is reduced gradually by 0.5-1mg every two to three days, until the optimum maintenance dosage is established (usual range between 1 and 4 mg per day)