Browse our anti-HSF4 (HSF4) Antibodies

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anti-Heat Shock Transcription Factor 4 Antibodies (HSF4)

On www.antibodies-online.com are 66 Heat Shock Transcription Factor 4 (HSF4) Antibodies from 13 different suppliers available. Additionally we are shipping HSF4 Kits (11) and HSF4 Proteins (5) and many more products for this protein. A total of 86 HSF4 products are currently listed.

concluded that the new mutation of c.331C>T in HSF4 DNA may be responsible for the autosomal dominant congenital cataract in this family

We found that HSF4 downregulation led to decrease of HIF1alpha (show HIF1A Antibodies) mRNA expression

HSF4 p.Arg116His recreates the childhood lamellar cataract in mice suggesting that incomplete penetrance associated with early cataracts may not be an absence but a limitation of the detection of the phenotype

This is the first report of the novel missense mutation, c.69 G-->T (p. K23N), in exon 3 of the HSF4 locus on 16q21-q22 associated with bilateral congenital cataracts in a Chinese family.

the transcriptional activation of HSF4 is mediated by interactions between activator and repressor domains within the C-terminal end.

These results revealed an essential role for HSF4-mediated SKAP2 expression in the regulation of actin reorganization during lens differentiation.

Data reveal the lens-specific role of heat shock transcription factor 4 (HSF4), and indicate that HSF1 (show HSF1 Antibodies) and HSF4 are involved in regulating expression of growth factor genes.

HSF4 fulfills a central role in controlling spatial and temporal expression of genes critical for correct development and function of the lens.

Molecular evaluation of Hsf4 revealed an early transposable element inserted in intron 9 leading to cataract formation.

HSF4 Antigen Profile

Antigen Summary

Heat-shock transcription factors (HSFs) activate heat-shock response genes under conditions of heat or other stresses. HSF4 lacks the carboxyl-terminal hydrophobic repeat which is shared among all vertebrate HSFs and has been suggested to be involved in the negative regulation of DNA binding activity. Two alternatively spliced transcripts encoding distinct isoforms and possessing different transcriptional activity have been described.