CHAPTER TOOLS

Keywords:

vaccines;

oral delivery;

tolerance;

immune responses;

transgenic plants;

clinical trial

Summary

Oral vaccines offer significant advantages as the polio eradication campaign has demonstrated, over delivery via needle and syringe. Additionally, mucosal immunity generated by oral vaccines, along with systemic immunity, can provide an important means of controlling infections that are caused by pathogens that infect the gut mucosa. There are a number of approaches being evaluated to deliver vaccines orally and efforts are also being devoted to understand the mechanism of determining the generation of oral immunity and overcoming oral tolerance.