Education

Research Interests

Mass Spectrometry-based Proteomics and Metabolomics

Systems Biology of Cancer

Molecular Pathogenesis of Alzheimer’s Disease

Ubiquitin and Proteome Turnover

Our mission is to develop novel mass spectrometry-based proteomics and metabolomics technologies, systems biology approaches, and to apply these tools to biomedical challenges (e.g. Alzheimer’s disease and cancer). We seek to profile the full spectra of temporal omics data including protein modifications (e.g. phosphoproteome and ubiquitinome) from cellular and animal models as well as human clinical specimens. Network analysis and integration of such large-scale omics data with genome, transcriptome, interactome and phenotypic information offer a systems or holistic view, for unbiased identification of central disease gene/protein networks, functional modules and master regulators. Beyond big data analysis, we perform a series of functional experiments to validate the derived hypotheses. These studies provide novel insights into the pathogenesis for therapeutic intervention, and may discover disease biomarkers for precision medicine.