Obese HIV-positive women with Metabolic Syndrome (HIV-MS) and obese HIV-negative women with Metabolic Syndrome will be studied before and after achieving moderate (6%-8%) diet-induced weight loss. The investigators hypothesize that health markers will improve in both groups but that the improvement will be blunted in the women with HIV-MS.

HIV-positive obese women with metabolic syndrome will be studied before and after losing 6-8% of body weight

Behavioral: Dietary Intervention

The nutrition curriculum will involve weekly group and individual sessions. The initial calorie goal will be ~750 kcal below the resting energy equivalent, and adjusted as needed to achieve weight loss targets.

Active Comparator: MS only

HIV-negative obese women with metabolic syndrome will be studied before and after losing 6-8% of body weight

Behavioral: Dietary Intervention

The nutrition curriculum will involve weekly group and individual sessions. The initial calorie goal will be ~750 kcal below the resting energy equivalent, and adjusted as needed to achieve weight loss targets.

Medical problems that in the opinion of the principal investigator may interfere with patient safety

Substance abuse

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Please refer to this study by its ClinicalTrials.gov identifier: NCT00857298