Untangle Tau Proteins with a Comprehensive Range of Research Tools

Introduction

An extensive range of research tools are available from Abcam to comprehensively study tau pathology. From aggregation inhibitors to antibodies and kits, customers can obtain everything they need to unravel tau, in one place.

Figure 1. Formation of neurofibrillary tangles (NFTs) by the tau protein in tauopathies such as Alzheimer’s disease (AD). Under pathological conditions tau becomes hyperphosphorylated and detaches from microtubules. Phosphorylated tau then aggregates to form paired helical filaments (PHFs) and neurofibrillary tangles (NFTs).

Total tau detection

In the normal brain, tau exists in soluble form. However, it aggregates and becomes insoluble in AD. Total tau can be easily detected with a BS and azide-free antibody, an ELISA kit, or an antibody panel from the table given below.

Note: Studying insoluble tau can be problematic, consider using detergents such as RIPA and Sarkosy1.

Tau phosphorylation

Phosphorylation, which governs tau function, becomes dysregulated during pathology, ending in mislocalization, aggregation, and neuronal death. All aspects of tau phosphorylation can be effortlessly studied with antibodies against different post-translationally modified sites.

Tau aggregation inhibitors

The presence of tau in aggregated form corresponds with pathology in diseases such as Alzheimer’s. The formation of neurofibrillary tangles can be effectively inhibited with a potent tau aggregation inhibitor.

Small molecule

Activity

abID

TRx0237 mesylate (LMTX)

Reduces tau pathology and reverses behavioral impairment in mice2. Active in vitro and in vivo3.

Tau and neuroinflammation

In neurodegenerative disease, there is a complex interplay between misfolded proteins and neuroinflammation. Abcam offers a range of tools to investigate proinflammatory mediators, which allows researchers to study tau in the context of neuroinflammation.

About Abcam

Abcam is a global life sciences company providing highly validated antibodies and other binders and assays to the research and clinical communities to help advance the understanding of biology and causes of disease.

Abcam’s mission is to serve life scientists to help them achieve their mission faster by listening to their needs, continuously innovating and improving and by giving them the tools, data and experience they want. Abcam’s ambition is to become the most influential life science company for researchers worldwide.

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