C-terminal peptide aldehydes are key components in oxime and hydrazine ligations and their synthesis is therefore very desirable. A well established method for the synthesis of C-terminal modified peptides including peptide aldehydes, is the backbone amide linker (BAL) strategy (Scheme 1).1 In this strategy, the first amino acid is anchored by reductive amination followed by acylation of the newly formed secondary amine. Thus, the growing peptide chain is anchored not through the C-terminal carboxyl but through a backbone amide nitrogen giving access to, in principle, any C-terminal modification.Tags: Application Notes

Biotage has developed a range
of tools to improve the peptide synthesis workflow,
from synthesis of crude peptides through to the final
purified product. These solutions make your workflow
more efficient and improve the quality of peptides
you synthesize. Our workflow solutions are used in
pharma, biotech, CRO and academic laboratories
throughout the world.Tags: Brochures

On Aug 30, 2017 a scientific literature search for the keywords Biotage AND peptide
was performed by Biotage personnel. The search identified 5380 peer-reviewed
publications from the global community, excluding patents and simple citations.
Below are approximately 100 titles illustrating the breadth and depth of research in
which Biotage tools are utilized.Tags: Customer Cases

This poster presents the synthesis of peptidoglycan fragments where the coupling of peptides and carbohydrates was achieved using microwave heating. The fully automated total synthesis of a complex branched peptide is also presented. The fragments were synthesized using Biotage® Initiator+ SP Wave, Biotage® Syro Wave™ and Biotage® Initiator+ Alstra™ respectively. Presented at EPS, Sofia, 2014.Tags: Posters

We have successfully developed a rapid and efficient microwave-assisted protocol for the preparation of Neu5Ac congeners that are important intermediates for clinically-relevant derivatives of Neu5Ac. The syntheses were performed using readily available reagents, improved on established techniques, and used more benign reagent for peracetylation. Moreover, the protocol that we developed is 1 to 2 orders of magnitude faster than conventional methods.
Initiator+ SPWave synthesis system
Dhananjaya Sahoo, I. Abrrey Monreal, and Jonel P. SaludesTags: English,
Posters

The application of microwave irradiation in solid
phase peptide synthesis (SPPS), is an important tool
for the synthesis of difficult and long peptide
sequences that are often obtained in poor quality by
comparable conventional methods at room
temperature. Here we present the results obtained
for the synthesis of a number of difficult peptide
sequences using different levels of automation for
microwave assisted SPPS: manual, semi-automated
and fully automated systems. Syro wave, initiator, sp waveTags: Posters

Introduction
• Solid-phase peptide synthesis (SPPS) is still often faced with challenges in the assembly of long and ‘difficult’ sequences, e.g. due to aggregation and steric hindrance giving rise to incomplete reactions. These problems have only partly been solved by new coupling reagents and solid supports.
• Precise microwave heating has emerged as one new parameter for SPPS, in addition to coupling
reagents, resins, solvents etc.Tags: Posters

Introduction
• Solid-phase peptide synthesis (SPPS) is still often
faced with challenges in the assembly of long and
‘difficult’ sequences, e.g. due to aggregation and
steric hindrance giving rise to incomplete reactions.
These problems have only partly been solved by
new coupling reagents and solid supports.
• Precise microwave heating has emerged as one
new parameter for SPPS, in addition to coupling
reagents, resins, solvents etc.Tags: Posters

Introduction
Solid-phase synthesis combined with fast and
precise heating by microwave irradiation has
become a valuable tool for peptide chemists. It
enables easier solid-phase assembly of difficult
peptide sequences and even small proteins. Here
we present, a study of microwave assisted solidphase
peptide synthesis using different resins on
the Syro WaveTM. Furthermore, we use this
methodology to synthesize difficult peptide
sequences including a multiple display
antimicrobial peptide.Tags: Posters

In peptide synthesis mode, this is the perfect tool for chemists synthesizing peptides and peptidomimetics, including difficult modifications and labeling of sequences, by using single or multi-step procedures. The intuitive Initiator 4.0 software controls the instrument functions and by using the pre-defined methods, synthesis can be started immediately.Tags: Product Notes

About Biotage

Biotage is a global Life Science company that develops innovative and effective solutions for separation within organic and analytical chemistry, as well as for industrial applications. Biotage is listed on NASDAQ Stockholm.