As of 3/22/17 Ortho Molecular is terminating online sales of its products. Once our Inventory is Gone - we will no longer be able to fulfill any Orders for Ortho Molecular Products.

Suggested Replacement:

Sedaplex by Integrative Therapeutics

Sedaplex

Restful Sleep Support

Respected Professional Supplement Manufacturer

Botanicalm PM by Ortho Molecular Products

Replacement product for Natural ZZZ - now includes hops.

Botanicalm PM is formulated to induce the relaxation needed to support better sleep for those experiencing temporary sleeplessness. The formula is especially suited to help those with difficulty falling asleep due to restlessness.

Clinical Applications

Supports Restorative Sleep

Helps Induce Relaxation

Supports Positive Mood

Busy and stressful lifestyles can cause sleep patterns to become disrupted, leading to over-stimulation and restlessness. Gamma-aminobutyric acid (GABA) is the brain’s primary neurotransmitter which helps to counteract stress by promoting a sense of relaxation. In the evening, GABA activity should increase in the brain, triggering the sleep cycle. The ingredients in Botanicalm PM work in synergy to support GABA activity and allow for optimal relaxation.

Botanicalm PM includes valerian root, a well-known herb used to help with sleep-related issues and to produce a state of relaxation. Passionflower and jujube have been used historically to produce a state of relaxation, and have been used in those with overstimulation and scattered thoughts. L-theanine, an amino acid found in green tea, supports resilience to stress by increasing alpha brain wave activity. Two capsules of Botanicalm PM include 450 mg valerian root extract, 200 mg jujube seed extract, 150 mg passionflower extract, 150 mg L-theanine and 100 mg hops strobile extract.

Questions and Answers

2 capsules one hour before sleep or as recommended by your health care professional.

Botanicalm PM is formulated to induce the relaxation
needed to support better sleep for those experiencing
temporary sleeplessness. The formula is especially suited to
help those with difficulty falling asleep due to restlessness.
Botanicalm PM includes valerian root, a well-known herb
used to help with sleep-related issues and to produce a
state of relaxation. Passionflower and jujube have been used
historically to produce a state of relaxation, and have been
used in those with overstimulation and scattered thoughts.
L-theanine, an amino acid found in green tea, supports
resilience to stress by increasing alpha brain wave activity.
Two capsules of Botanicalm PM include 450 mg valerian root
extract, 200 mg jujube seed extract, 150 mg passionflower
extract, 150 mg L-theanine and 100 mg hops strobile extract.

Overview

Busy and stressful lifestyles can cause sleep patterns
to become disrupted, leading to over-stimulation and
restlessness. Gamma-aminobutyric acid (GABA) is the brain’s
primary neurotransmitter which helps to counteract stress by
promoting a sense of relaxation. In the evening, GABA activity
should increase in the brain, triggering the sleep cycle. The
ingredients in Botanicalm PM work in synergy to support GABA
activity and allow for optimal relaxation. While other therapies
with a similar mechanism may cause dependency when used
over an extended period of time, the natural ingredients in
Botanicalm PM are non-habit-forming.

Valerian Root Extract†

Valerian root extract is perhaps the most studied botanical for
inducing sleep. Valerenic acid, an active component in valerian
root, has spasmolytic or muscle relaxant properties. It has been
found to both inhibit the reuptake of and stimulate the release
of GABA in the central nervous system (CNS).1,2 In addition,
other components within valerian have been found to bind
to GABA receptors.3
Randomized trials consistently show
significant benefits to supplementing valerian over placebo.4
One randomized, double-blind, placebo-controlled trial
comparing 600 mg/day of valerian extract given with another
therapy for six weeks showed valerian root extract to be equally
effective in supporting sleeplessness as a traditional approach.5

Passionflower Extract†

The aerial portions of passionflower are best known for their
historic use as a relaxing and calming herb. Numerous flavonoid
components function as active ingredients6
by binding to
the GABA receptor.7,8 Passionflower extract has compared
favorably with other therapies with similar mechanisms of
easing feelings of overstimulation and scattered thoughts,
with fewer side effects.9
A randomized, placebo-controlled
trial of 60 people, aged 25-55 years and scheduled for spinal
anesthesia, showed those given passionflower experienced
a greater sense of calmness before being given anesthesia.10
Passionflower has also been shown to offer sleep benefits for
adults with fluctuations in sleep quality.11

L-Theanine†

L-theanine is an amino acid found in green tea, and is considered
a relaxant (although not a sedative) when used alone. The
Food and Drug Administration has approved several health
claims for L-theanine including: stress reduction, relaxation
without drowsiness, decreased nervousness from common fatigue, and reduced nervous irritability. L-theanine has been
shown to significantly increase alpha brain wave activity which
correlates with a perceived state of relaxation.12

Jujube Extract†

Wild jujube seed has been historically used in traditional
Chinese medicine as a sedative herb. It has been shown to
reduce stress, conserve energy and promote sleep. It is useful
for those with symptoms of nervous exhaustion, fatigue,
irritability and the inability to sleep.13 (Note: Most research on
the active components [jujubosides A and B] for sedative and
CNS function has been performed in China and are written in
Chinese).14-17

Hops Strobile Extract†

The hops plant, Humulus lupulus, is a perennial climbing vine
that has been used for centuries for its relaxing properties,
among other health benefits. Only the female hops, which
produce flowers known as strobiles, are used for medicinal
purposes. The active ingredients in hops include a volatile
oil, valerianic acid, tannins and flavonoids. European studies
have examined the effects of hops in combination with other
sleep-supporting botanicals. In a pilot study that included
30 subjects with mild-to-moderate sleep challenges, a
preparation combining 500 mg of valerian extract with 120 mg
hops was given to subjects 30 minutes before bedtime. The
hops-valerian preparation was found to improve sleep quality
by decreasing sleep latency and wake time throughout the
night.18

Directions

2 capsules one hour before sleep or as recommended by your
health care professional.

Does Not Contain

Gluten, yeast, artificial colors and flavors.

Cautions

Do not consume this product if you are pregnant or nursing.
Consult your physician for further information.