Abstract

With advanced age, articular calcium pyrophosphate crystal deposition (CPPD) is common.
Defining who has CPPD is of growing importance, given increases in longevity in many
countries and the frequent association of chondrocalcinosis with osteoarthritis. Chondrocalcinosis
detected by plain radiography serves as a major screening tool, but how many and which
sites to screen have not been adequately defined in the past. The work of Abhishek
and colleagues in the previous issue of Arthritis Research and Therapy sheds new light on the incomplete information from knee radiographs, and helps position
us to learn more about the epidemiology, pathophysiology, diagnosis, and clinical
impact of CPPD.