It shouldn't have any very noticeable effect really (outside of filling the
bin directory with a couple Python modules). The Python programs should
just use the system Python instead. (This is the only available approach
in the upcoming version).

A couple other things are written in Python, though, so it wouldn't _just_
be MMPBSA to be affected. (The constant pH input utility is written in
Python as well, as is a softcore TI setup script).