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The seventh-ranked Spartans were coming off a draining loss to rival Michigan and again were down two starters to surging Iowa, which was hosting its biggest game in years.

Michigan State responded with the toughness it has shown so often under coach Tom Izzo and emerged with a key win.

Keith Appling scored 16 and the Spartans outlasted No. 15 Iowa 71-69 in overtime Tuesday night, handing the Hawkeyes their first home loss.

"I was concerned coming in whether we could get back up off the can. Not physically, we were going to be beat up. I was worried about mentally," said Izzo, whose team fell to the Wolverines 80-75 on Saturday. "We didn't have time to be tired."

Matt Costello had 11 points and 12 rebounds for the Spartans (19-2, 8-1 Big Ten), who avoided consecutive defeats despite the absence of injured starters Adreian Payne and Branden Dawson. It took five extra minutes, and an Iowa shooting drought that lasted nearly 15 minutes, to pull it off.

Costello's tip-in with 1:14 left gave Michigan State a 67-64 lead. Russell Byrd's 3 with 34 seconds left gave the Spartans a six-point lead over the Hawkeyes (16-5, 5-3) .

"I just didn't think we were tough enough. We weren't tough at all," Iowa coach Fran McCaffery said. "I think they were being nice."

NO. 4 WICHITA ST. 57, LOYOLA OF CHICAGO 45: Cleanthony Early scored 23, including 12 of the Shockers' 21 in the second half, and host Wichita State (22-0, 9-0 MVC) extended school records for winning streak and start to a season.

LSU 87, NO. 11 KENTUCKY 82: Johnny O'Bryant III had 29 points and nine rebounds, and the Tigers led wire-to-wire to upset the Wildcats (15-5, 5-2 SEC), whose losses have all been on the road.