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ARIAD Pharmaceuticals announced updated clinical data on its investigational tyrosine kinase inhibitor, brigatinib, in patients with anaplastic lymphoma kinase-positive advanced non-small cell lung cancer from an ongoing Phase 1/2 trial. "The long-term follow up on this clinical trial of brigatinib continues to show anti-tumor activity with a confirmed overall objective response rate of 62 percent in crizotinib-resistant ALK-positive NSCLC patients at all doses evaluated, and 76 percent among those patients who received the 180 mg dose regimen with a seven-day lead-in at 90 mg once daily. The median progression-free survival in this post-crizotinib ALK+ NSCLC patient group continues to exceed one year," stated Lyudmila A. Bazhenova, M.D., a clinical professor of medicine at the University of California San Diego Moores Cancer Center.

ARIAAcquired by TKPYY 2/17

$13.40

0.05 (0.37%)

08/22/16

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08/22/16NO CHANGEGSCO

Goldman lists companies to be in focus after Medivation deal

After Pfizer (PFE) announced it has agreed to acquire Medivation (MDVN) for $81.50 per share in cash, Goldman Sachs analyst Salveen Richter said he expects a focus on other commercial small-to-mid-cap cancer companies, including Incyte (INCY), Seattle Genetics (SGEN), ARIAD (ARIA) and Exelixis (EXEL). Also noting that Sanofi (SNY), which was pursuing Medivation, has recently suggested an interest in a rare disease transaction up to potentially as large as $20B, he would expect rare disease companies of that size - such as BioMarin (BMRN), Amicus (FOLD) and Ultragenyx (RARE) - to be in focus as well.

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