- Application of anticoagulants or vitamin K antagonists such as warfarin, heparin or
its analogues; If the prothrombin time international normalized ratio (INR) ≤ 1.5,
with the purpose of prevention, the use of small doses of warfarin (1mg orally, once
daily) or low-dose aspirin (between 80mg to 100mg daily) is allowed.

- Abuse of alcohol or drugs

- Less than 4 weeks from the last clinical trial

- Treatment with VEGFR, PDGFR, sSRC-TKI before.

- History of any second malignancies within 3 years except cured basal cell carcinoma
of skin and carcinoma in-situ of uterine cervix.

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Completion Date:

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