Herbs and Supplements to Use Only With Caution

The substances collagen and elastin give skin its firmness and elasticity. With age, though, the collagen and elastin content of the skin gradually decreases. As a result, the skin becomes looser, weaker, less elastic, and drier. In addition, the fat pads under the skin begin to disappear. Wrinkles form, and the skin begins to sag.

In people who already have signs of aging skin and wish to reverse it, a number of treatments are available.

The drug tretinoin (retinoic acid, or Retin-A), a substance related to
vitamin A
, has been shown effective for reversing the fine wrinkles, splotchy pigmentation, and rough skin of sun damage.

The hormone estrogen is thought to help restore normal skin tone in menopausal women, but the evidence for this widely held belief remains weak.

More aggressive treatments for aging skin include injections of botulin toxin, dermabrasion, chemical peels, soft tissue augmentation, laser resurfacing, and GORE-TEX® threads. For detailed information on the relative merits and demerits of these methods, consult a dermatologist or plastic surgeon.

Principal Proposed Natural Treatments

Two classes of natural treatments have shown promise in the treatment of aging skin: alpha-hydroxy acids (AHAs) and antioxidants. However, the evidence that they work remains incomplete, and AHAs can cause significant side effects.

Alpha-hydroxy Acids

Alpha-hydroxy acids, such as glycolic acid and lactic acid, are substances derived from fruit and dairy products. These are milder relatives of the substances used by dermatologists in chemical peels, which are designed to remove damaged layers of the skin. In recent years, cosmetic manufacturers have begun to add AHAs to numerous skin-care products.

Meaningful evidence in support of AHAs comes from one
double-blind, placebo-controlled
study reported in 1996.
1
This 22-week study enrolled 74 women with sun-damaged skin. Participants received either 8% glycolic acid, 8% L-lactic acid, or placebo cream, and applied it to the face and forearm. Although participants showed improvements in each of the three groups, superior results were achieved with each of the AHA creams than with the placebo cream.

AHAs are not always harmless. Possible side effects include burning, blistering, severe redness, swelling (especially in the area of the eyes), bleeding, rash, and increased sensitivity to the sun.
2
There are also concerns that AHAs may increase risk of skin cancer. For all these reasons, the FDA is currently investigating the use of AHAs in cosmetic products to determine whether they should be reclassified as drugs.

Antioxidants

The ultraviolet light from the sun creates free radicals, naturally occurring substances that can harm many tissues of the body, including the skin.
Antioxidants
are substances that neutralize free radicals. On this basis, various antioxidants have been investigated for their potential usefulness in treating or preventing photoaging. (Note, however, the surprising results described at the
end
of this subsection.)

A small, 3-month, double-blind, placebo-controlled study found benefit with a cream containing 5%
alpha-lipoic acid
.
27
Use of this antioxidant substance improved several measures of aging skin as compared to placebo, especially skin roughness. Benefits have also been seen in preliminary studies with a cream containing
vitamin C
.
3,4

Oligomeric proanthocyanidin complexes (OPCs)
made from grape seed or pine bark are widely marketed for the treatment of aging skin. These substances, closely related to
bioflavonoids
, have antioxidant properties and might also protect and strengthen collagen and elastin.
5-10
These effects provide theoretical reasons to believe that OPCs might be helpful for the treatment of aging skin. However, despite widespread marketing, no properly designed studies have been reported to indicate that OPCs really provide any benefit.

In an 8-week double-blind, placebo-controlled study of 40 women who already had sun-damaged skin, combined use of oral
green tea
and a topical green tea cream failed to prove more effective than placebo in improving the condition of sun-damaged skin.
29
Some possible benefits were seen in microscopic evaluation of skin condition.

Antioxidant substances have also been studied as aids to
preventing
sun damage.

One small, double-blind study found that 2 g of vitamin C and 1,000 IU of vitamin E taken orally for 8 days resulted in a modest decrease of "sunburn" induced by ultraviolet light.
15
In addition, a 50-day, placebo-controlled study of 40 people found that higher doses of these vitamins provided a sun protection factor of about 2.
16
(Compare this to the sun protection factor of 15 or higher in many sunscreens.) It appears that these vitamins must be taken together for best effect; when used alone they do not appear to work.
16,17,40

Oral use of
beta-carotene
,
lycopene
,
and other
carotenoids
has shown preventive effects in some but not all studies.
25,30-31
Benefits have also been seen with mixtures of various antioxidants taken together (vitamin E, zeoxanthin, lutein, beta-carotene, and others).
32-33

Oral
vitamin A
has shown some promise for preventing skin cancer in people at risk for it, but the doses used in studies were quite high, considerably above current recommendations for the maximum safe dose.
28
(
Note:
Do not use vitamin A along with the drug tretinoin. See
Safety Issues
.)

Topical vitamin A may be helpful for treatment of aging skin. One double-blind, placebo-controlled study found that a 0.4% vitamin A lotion applied three times a week significantly reduced the number of “fine” wrinkles in seniors.
42
Benefits were also seen in terms of some biochemical measures of skin health.

Because these antioxidants work in an entirely different manner from standard sunscreen, it appears reasonable to believe that they might offer a synergistic effect if taken with sunscreen. However, this hypothesis has not been studied.

Other substances with antioxidant actions that have shown some promise for treating or preventing aging skin include
cocoa
,
39Vitis vinifera
extract,
43milk thistle
,
21
and
zinc
.
21
However, the supporting evidence that use of these substances (taken either orally or topically) offers any benefit for the skin remains far too preliminary to be relied upon at all.

Note
: Any discussion of the potential benefits of antioxidants for preventing cancer must include the startling finding of a large study that tested the effect of mixed antioxidants. This trial, enrolling 7,876 women and 5,141 men, evaluated the potential benefits of a combination of vitamin C, vitamin E, beta-carotene, selenium, and zinc for preventing cancer. According to results published in 2007, no benefits were seen among male participants, but among women, skin cancer rates actually appeared to
increase
.
44
The cause of these findings remains unclear.

Other Proposed Natural Treatments

In a double-blind study of 50 women with signs of aging skin, use of topical
niacinamide
cream significantly improved skin appearance and elasticity as compared to placebo cream.
34

A study published in 2007 tested a purified soy
isoflavone
product (technically, isoflavone aglycones) for treatment of
aging skin
.
41
In this double-blind trial, 26 Japanese women in their late 30s and early 40s were either given placebo or 40 mg daily of soy isoflavone aglycones for 12 weeks. Researchers monitored two types of wrinkles near the eye: “fine” wrinkles and “linear” wrinkles. The results indicated that use of the soy product significantly reduced “fine” wrinkles as compared to placebo. (Effects on “linear” wrinkles were not significant.) As a secondary measure, researchers also analyzed skin elasticity, and found an improvement in the women given the isoflavones as compared to those given placebo.

An unusual soy extract containing soybean trypsin inhibitor (STI) and Bowman-Birk protease inhibitor (BBI) has also shown promise for aging skin.
45
Sixty-five women with moderate skin damage from the sun either received soybean extract or placebo cream for 12 weeks. Compared to the women in the placebo group, treated women showed an improvement in mottled pigmentation, blotchiness, dullness, fine lines, as well as an overall enhancement of texture, skin tone, and appearance.

The substance
glucosamine
is widely used for osteoarthritis in part because it seems to help collagen regenerate. For this reason, it has been advocated as a treatment for aging skin. However, the only evidence that it works comes from one poorly designed study. In this
single-blind trial
, 72 women with symptoms of aging skin were divided into two unequal groups: a small group that received no treatment, and a much larger one that received a proprietary mixture of glucosamine, amino acids, and minerals.
22
The results indicated greater improvement in the treated group as compared to the untreated group. However, because this was not a double-blind, placebo-controlled study, the results cannot be taken as reliable.

The mineral
silicon
has also been proposed as a treatment for aging skin. In the one potentially meaningful published study, 50 women with sun-damaged skin were given either 10 mg silicon daily (as orthosilicic acid) or placebo for 20 weeks.
35
Measurements of skin roughness and elasticity showed improvement in the silicon group as compared to the placebo group. However, this study, performed by the manufacturer of a silicon product, leaves much to be desired in design and reporting.

A proprietary dietary supplement containing
soy
, fish protein polysaccharides, white tea extract, and many other ingredients has also shown promise, according to a study performed by the manufacturer.
37

One study provides weak evidence that the substance
DHEA
(dehydroepiandrosterone) might be helpful for improving skin condition in seniors.
38

In a preliminary, double-blind blind study,
coriander oil
applied topically was more effective than a placebo cream at reducing redness due to UVB exposure.
46
This effect may or may not translate into long-term benefit for aging sun-damaged skin.

Numerous herbs and other natural products have been advocated for the treatment of aging skin, including
aloe
, arnica,
calendula
,
chamomile
, dead sea minerals,
gotu kola
,
PABA
, thuja, and
vitamin A
. Other products claim to contain biological substances called “growth factors”—with names such as IGF-1, IGF-2, TGF-A, TGF-B, EGF, and FGF—and go on to claim that these growth factors improve skin condition. Still others supposedly raise levels of human growth hormone in the body and, therefore, help produce youthful skin. However, there is no meaningful evidence that any of these treatments actually work.

So-called “
acupuncture
face lifts” are widely available for treating facial wrinkles. They involve a series of treatments in which fine needles are inserted into the face. However, there is no evidence to indicate this method produces any benefit.

Herbs and Supplements to Use Only With Caution

The herb
St. John’s wort
contains a substance, hypericin, that increases the skin’s sensitivity to the sun.
23,24
For this reason, it is possible that use of St. John’s wort could accelerate sun damage of skin.

People using the drug tretinoin (Retin-A) should not take high doses of
vitamin A
, as each might increase the toxicity of the other.

Revision Information

This content is reviewed regularly and is updated when new and relevant evidence is made available. This information is neither intended nor implied to be a substitute for professional medical advice. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with questions regarding a medical condition.

Tixier JM, Godeau G, Robert AM, et al. Evidence by in vivo and in vitro studies that binding of pycnogenols to elastin affects its rate of degradation by elastases.
Biochem Pharmacol.
1984;33:3933-3939.