1Division of Comparative Pathology, Tulane National Primate Research Center, Covington, Louisiana, United States of America.

Abstract

BACKGROUND:

The Gastrointestinal (GI) tract is critical to AIDS pathogenesis as it is the primary site for viral transmission and a major site of viral replication and CD4(+) T cell destruction. Consequently GI disease, a major complication of HIV/SIV infection can facilitate translocation of lumenal bacterial products causing localized/systemic immune activation leading to AIDS progression.

The relative size of each sector in the pie chart is determined by the number of genes in that functional category. Genes with unknown function are not included in the pie chart. Only a few transcripts of importance to SIV infection are shown in the figure under each functional category. The full list of genes grouped under each functional category for the 21d time point is provided in .

The relative size of each sector in the pie chart is determined by the number of genes in that functional category. Genes with unknown function are not included in the pie chart. Only a few transcripts of importance to SIV infection are shown in the figure under each functional category. The full list of genes grouped under each functional category for the 21d time point is provided in .

The relative size of each sector in the pie chart is determined by the number of genes in that functional category. Genes with unknown function are not included in the pie chart. Only a few transcripts of importance to SIV infection are shown in the figure under each functional category. The full list of genes grouped under each functional category for the 90d time point is provided in .

The relative size of each sector in the pie chart is determined by the number of genes in that functional category. Genes with unknown function are not included in the pie chart. Only a few transcripts of importance to SIV infection are shown in the figure under each functional category. The full list of genes grouped under each functional category for the 90d time point is provided in .