Bulls-Eye Bill, (or Missile Bill, Heat-Seeking Bullet Bills in the New Super Mario Bros. Wii Prima Guide), is a variation of Bullet Bills and they have first appeared in Super Mario Bros. 3. The Bulls'-Eye Bill shoots straight unless Mario gets within its sight range, he then locks onto Mario and follows him. Like Bullet Bills, Bulls'-Eye Bills are explosive.

They are shot out of Monty Mole's cannon and can be defeated by being jumped on or when Mario uses F.L.U.D.D. to attack. They can destroy the baskets on Pinna Park containing Blue Coins which is the only method to gain the Blue Coins and to destroy the baskets. Bulls'-Eye Bills can also be gold in this game and release coins when jumped on. They are used in the final battle against Bowser and Bowser Jr. where Bowser Jr. throws some at Mario and may also send out a blue Bulls'-Eye Bill that either releases a 1-up Mushroom or a Water Bottle.

They make their most recent appearance in New Super Mario Bros. Wii where they act similar as they do in Super Mario Bros. 3, except for the fact that they can change the direction they go in. They only appear in World 9-3 where subspecies, Missile Banzai Bills are also found. They continuously chase Mario and co. unless they are far enough from it or when jumped on.