Write-up: This case was reported by a physician in the frame of a study and described the occurrence of intussusception in a 4-month-old male subject who was vaccinated with ROTARIX, GlaxoSmithKline. The subject was under no other medication and had no relevant medical history nor allergy. On 29 April 2008, the subject received 1st dose of ROTARIX (oral), lot number not provided. On 17 May 2008, 18 days after vaccination with ROTARIX, the subject experienced bloody stools like current jelly stool. He was brought to the emergency ward. The physical examination showed fever and rectal bleeding with an abdomen without other clinical sign. Barium enema was performed and confirmed intussusception. On 17 May 2008, surgery was performed and ileocolic intussusception was found and reduced by taxis without complication. The subject was hospitalised for 4 days. The subject was treated with ranitidine hydrochloride, ampicillin sodium, paracetamol, ampicillin trihydrate and vitamin k. On 20 May 2008, the events were resolved and the subject was discharged from hospital. The physician considered the events were possibly related to vaccination with ROTARIX.