O-Glycosidase

Specifictity Cleaves only unsubstituted Gal-Beta(1-3)GalNAc-alpha disaccharides attached to the serine or threonine residues of glycoproteins or glycopeptides.
Substitutions such as sialic acid, galactose, fucose or N-acetylglucosamine must first be removed with the appropriate exoglycosidase prior to treatment with Endo-O-Glycosidase.
At minimum, a sialadase such as Sialadase Au (alpha-2-3,6,8,9), part number E-S001, is almost always required to remove sialic acids