The resignation is the most recent setback for Weiner, a Democrat who resigned from Congress in 2011 after the public learned he had been sending sexual photographs and messages to women via social media accounts.

Last week, Weiner, a married father, publicly acknowledged he continued with the inappropriate messaging after his resignation.

He was forced to discuss his online behavior after a gossip website printed excerpts of his conversations last summer with Indiana college student Sydney Leathers.

Kedem’s resignation was reported first by The New York Times, then confirmed Sunday morning by at least two other news-gathering agencies, including The New York Post, which spoke directly to Weiner.

"Danny has left the campaign,” Weiner told The Post. “He did a remarkable job."

Weiner’s attempted comeback got off to an expected rocky start, but he slowly rose in polls. However, the revelations last week appeared to have lessened his favorability among potential voters.

The most recent NBC 4 New York/Wall Street Journal/Marist poll shows Weiner’s support among registered Democrats now at 19 percent, a drop of 9 percentage points, with City Councilwoman Christine Quinn now in the lead at 25 percent.

“I think it has become very clear … Weiner has a pattern of misbehavior,” Quinn told NBC’s “Meet the Press,” adding she didn’t think he should stay in the race.

Though the 31-year-old Kedem’s departure is not expected to make a huge impact on Weiner’s day-to-day campaign operations, his departure suggests a loss of support for the candidate amid his already small staff.

Kedem had managed the re-election of John DeStefano Jr. to a 10th term as mayor of New Haven in 2011and worked on Hillary Clinton’s 2008 presidential campaign, according to The Times.