MAPK7

MAPK7

A gene on chromosome 17p11.2 that encodes a member of the MAP kinase family, which integrate multiple biochemical signals and are involved in cell proliferation, differentiation, transcription, regulation and development. MAPK7 is activated by MAPK kinase 5—which is formed from MAPK2K5 and MEK5; it translocates to the nucleus, undergoes phosphorylation and regulates gene expression.

In the present study, the level of miR-143 was reduced, while the expression and phosphorylation of ERK5 and MAP3K7 were increased in BC tissues compared with noncancerous tissues or NC breast tissues.

ERK5 is a member of the MAPK family, which has been reported as an enhancer of cell proliferation and progression by mediating the cell cycle, as well as a tumorigenesis (26).

Moreover, we also revealed that miR-143 regulated cyclin D1 expression through down-regulation of ERK5.

In conclusion, the present study reveals that both ERK5 and MAP3K7 may be the target genes of miR-143.

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