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I would like to know what other Dr's say about this also. My Dr. told me to be safe take nothing. I had wanted to take fish oil (which she said most likely had some form of Vit A in it), biotin, and a Vit E (she said an anti-oxidant would inhibit the effectiveness of Accutane). This is my second time on Accutane and after the first round I felt like I had aged. My skin had been so dry I felt like I had more wrinkles and some new stretch marks. Many patients mention taking these supplements why is my Dr telling me to take nothing?