Patent application title: COLD MENTHOL RECEPTOR-1 ANTAGONISTS

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Abstract:

The invention is directed to TRPM8 antagonists of Formula (I). More
specifically, the present invention relates to certain novel compounds,
methods for preparing compounds, compositions, intermediates and
derivatives thereof and methods for treating TRPM8-mediated disorders.
Pharmaceutical and veterinary compositions and methods of treating pain
and various other disease states or conditions using compounds of the
invention are also described.

Claims:

1-37. (canceled)

38. A compound of Formula (Ia) ##STR00075## selected from the group
consisting of a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is methyl, X is S, R1 is isopropyloxy, R2
is isopropyloxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is i-propyl, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 3,4-difluoro-phenyl; a
compound of Formula (Ia) wherein A is 4-fluoro-benzo, W is C(R4),
R4 is methyl, X is S, R1 is ethoxy, R2 is ethoxy, R3
is H, L is CH2, and B is 3,4-difluoro-phenyl; a compound of Formula
(Ia) wherein A is benzo, W is C(R4), R4 is methyl, X is S,
R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B
is 3-chloro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is cyclopentyl, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 3,4-difluoro-phenyl; a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
methyl, X is S, R1 is ethoxy, R2 is isobutyl, R3 is H, L
is CH2, and B is 3,4-difluoro-phenyl; a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is methyl, X is S, R1
is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3-fluoro-phenyl; a compound of Formula (Ia) wherein A is 7-fluoro-benzo,
W is C(R4), R4 is methyl, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 3,4-difluoro-phenyl; a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
methyl, X is O, R1 is ethoxy, R2 is ethoxy, R3 is H, L is
CH2, and B is 3,4-difluoro-phenyl; a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is methyl, X is S, R1
is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
2,3-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is methyl, X is O, R1 is isopropyloxy, R2
is isopropyloxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is chloro, X is S, R1 is isopropyloxy, R2
is isopropyloxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is methyl, X is S, R1 is isobutyl, R2 is
isobutyl, R3 is H, L is OCH2, and B is 3,4-difluoro-phenyl; a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
methyl, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is
CH2, and B is 3,4-difluoro-phenyl; a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is
6-fluoro-benzo, W is C(R4), R4 is methyl, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is methyl, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 3,5-difluoro-phenyl; a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
methyl, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is
CH2, and B is 3-methyl-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is i-propyl, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W
is C(R4), R4 is cyclopropyl, X is S, R1 is isopropyloxy,
R2 is isopropyloxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is methyl, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 3,4-dichloro-phenyl; a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
methyl, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is
CH2, and B is 2-fluoro-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is methyl, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
2-fluoro-3-chloro-phenyl; a compound of Formula (Ia) wherein A is benzo,
W is C(R4), R4 is bromo, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 3,4-dichloro-phenyl; a
compound of Formula (Ia) wherein A is benzo, W is N, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W
is C(R4), R4 is methyl, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 2-methyl-phenyl; a compound
of Formula (Ia) wherein A is benzo, W is C(R4), R4 is methyl, X
is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2,
and B is 2-chloro-4-fluoro-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is methyl, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
2-chloro-3,5-difluoro-phenyl; a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is cyclopropyl, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is methyl, X is S, R1 is ethoxy, R2 is
methyl, R3 is H, L is CH2, and B is 3,4-difluoro-phenyl; a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
methyl, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is
CH2, and B is 3-trifluoromethyl-4-fluoro-phenyl; a compound of
Formula (Ia) wherein A is benzo, W is C(R4), R4 is methyl, X is
S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and
B is 3-methoxy-phenyl; a compound of Formula (Ia) wherein A is benzo, W
is C(R4), R4 is methyl, X is S, R1 is isobutyl, R2 is
isobutyl, R3 is H, L is CH2, and B is 3,4-difluoro-phenyl; a
compound of Formula (Ia) wherein A is (2,3-b)pyridin-2-yl, W is
C(R4), R4 is methyl, X is S, R1 is isopropyloxy, R2
is isopropyloxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is methyl, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 2,3-dichloro-phenyl; a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
methyl, X is S, R1 is ethoxy, R2 is isobutyl, R3 is H, L
is CH2, and B is 3,4-difluoro-phenyl; a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is methyl, X is S, R1
is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
2-fluoro-3-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is cyclopentyl, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W
is C(R4), R4 is H, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 3-trifluoromethyl-phenyl; a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
methyl, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is
CH2, and B is 3-bromo-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is cyclobutyl, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is methyl, X is S, R1 is n-propyl, R2 is
n-propyl, R3 is H, L is OCH2, and B is 3,4-difluoro-phenyl; a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
trifluoromethyl, X is S, R1 is isopropyloxy, R2 is
isopropyloxy, R3 is H, L is CH2, and B is 3,4-difluoro-phenyl;
a compound of Formula (Ia) wherein A is benzo, W is C(R4), R4
is methyl, X is S, R1 is n-propyl, R2 is n-propyl, R3 is
H, L is CH2, and B is 3,4-difluoro-phenyl; a compound of Formula
(Ia) wherein A is 5-fluoro-benzo, W is C(R4), R4 is methyl, X
is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2,
and B is 3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is methyl, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is naphthalen-2-yl;
a compound of Formula (Ia) wherein A is benzo, W is C(R4), R4
is methyl, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L
is CH2, and B is 2,5-dichloro-phenyl; a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is methyl, X is S, R1
is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
2-chloro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is methyl, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is
3-trifluoromethyl-4-chloro-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is methyl, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is 4-fluoro-phenyl;
a compound of Formula (Ia) wherein A is benzo, W is C(R4), R4
is H, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is
CH2, and B is 4-fluoro-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is methyl, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein A is benzo,
W is C(R4), R4 is methyl, X is S, R1 is
2,2-dimethyl-propyl, R2 is 2,2-dimethyl-propyl, R3 is H, L is
CH2, and B is 3,4-difluoro-phenyl; a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is methyl, X is S, R1
is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
2,6-dichloro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is methyl, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 4-trifluoromethoxy-phenyl;
a compound of Formula (Ia) wherein A is benzo, W is C(R4), R4
is methyl, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L
is CH2, and B is 3-fluoro-5-trifluoromethyl-phenyl; a compound of
Formula (Ia) wherein A is benzo, W is C(R4), R4 is methyl, X is
S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and
B is 3-trifluoromethoxy-phenyl; a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is H, X is S, R1 is ethoxy, R2
is ethoxy, R3 is H, L is CH2, and B is
3-fluoro-4-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is methyl, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
2-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein A is benzo,
W is C(R4), R4 is methyl, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is
2-fluoro-3-methyl-6-chloro-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is methyl, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
2-trifluoromethoxy-phenyl; a compound of Formula (Ia) wherein A is
5-methyl-benzo, W is C(R4), R4 is methyl, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W
is C(R4), R4 is H, X is S, R1 is isopropyloxy, R2 is
isopropyloxy, R3 is H, L is CH2, and B is 3,4-difluoro-phenyl;
a compound of Formula (Ia) wherein A is benzo, W is C(R4), R4
is phenyl, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L
is CH2, and B is 3,4-dichloro-phenyl; a compound of Formula (Ia)
wherein A is 4-chloro-benzo, W is C(R4), R4 is methyl, X is S,
R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B
is 3,4-dichloro-phenyl; a compound of Formula (Ia) wherein A is benzo, W
is C(R4), R4 is methyl, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 2-bromo-phenyl; a compound
of Formula (Ia) wherein A is benzo, W is C(R4), R4 is methyl, X
is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2,
and B is 2-fluoro-5-trifluoromethyl-phenyl; a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is H, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
4-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein A is benzo,
W is C(R4), R4 is H, X is S, R1 is isopropyloxy, R2
is isopropyloxy, R3 is H, L is CH2, and B is
3-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein A is benzo,
W is C(R4), R4 is H, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 4-bromo-phenyl; a compound
of Formula (Ia) wherein A is benzo, W is C(R4), R4 is methyl, X
is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2,
and B is 5-chloro-benzo[1,3]dioxol-6-yl; a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is methyl, X is S, R1
is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3-(pyridin-4-yl)-phenyl; a compound of Formula (Ia) wherein A is benzo, W
is C(R4), R4 is methyl, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is
2-fluoro-3-chloro-5-trifluoromethyl-phenyl; a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is H, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is phenyl;
a compound of Formula (Ia) wherein A is benzo, W is C(R4), R4
is H, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is
CH2, and B is 3,4-difluoro-phenyl; a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is methyl, X is S, R1
is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
2,4-dichloro-5-fluoro-phenyl; a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is methyl, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is 3-biphenyl; a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
H, X is S, R

1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-dichloro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is methyl, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is CH3, L is CH2, and B is 3,4-difluoro-phenyl;
a compound of Formula (Ia) wherein A is benzo, W is C(R4), R4
is H, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is
CH2, and B is 2-fluoro-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is methyl, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
2-chloro-3-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein A
is 6-methoxy-benzo, W is C(R4), R4 is methyl, X is S, R1
is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is H, X is S, R1 is ethoxy, R2 is ethoxy,
R3 is H, L is CH2, and B is naphthalen-2-yl; a compound of
Formula (Ia) wherein A is 4-trifluoromethyl-benzo, W is C(R4),
R4 is methyl, X is S, R1 is ethoxy, R2 is ethoxy, R3
is H, L is CH2, and B is 3,4-difluoro-phenyl; a compound of Formula
(Ia) wherein A is benzo, W is C(R4), R4 is H, X is S, R1
is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
2-chloro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is H, X is O, R1 is ethoxy, R2 is ethoxy,
R3 is H, L is CH2, and B is 4-fluoro-phenyl; a compound of
Formula (Ia) wherein A is benzo, W is C(R4), R4 is methyl, X is
SO2, R1 is ethoxy, R2 is ethoxy, R3 is H, L is
CH2, and B is 3,4-difluoro-phenyl; a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is H, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
2-methyl-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is H, X is S, R1 is ethoxy, R2 is ethoxy,
R3 is H, L is CH2, and B is benzothiophen-2-yl; a compound of
Formula (Ia) wherein A is benzo, W is C(R4), R4 is methyl, X is
S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and
B is 4-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein A is
5-chloro-benzo, W is C(R4), R4 is methyl, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W
is C(R4), R4 is bromo, X is S, R1 is isopropyloxy, R2
is isopropyloxy, R3 is bromo, L is CH2, and B is
3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is H, X is S, R1 is ethoxy, R2 is
2,6-dichloro-phenylmethoxy, R3 is H, L is absent, and B is H; a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
H, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is
CH2, and B is 2,6-dichloro-phenyl; a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is H, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3,5-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is H, X is S, R1 is ethoxy, R2
is ethoxy, R3 is H, L is CH2, and B is
2-chloro-4-fluoro-phenyl; a compound of Formula (Ia) wherein A is benzo,
W is C(R4), R4 is methyl, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is
2-chloro-5-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is H, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
2,3-dichloro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is methyl, X is S, R1 is cyclohexyloxy, R2
is cyclohexyloxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is H, X is S, R1 is ethoxy, R2 is ethoxy,
R3 is H, L is CH2, and B is 2-trifluoromethyl-phenyl; a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
methyl, X is S, R1 is ethoxy, R2 is
2-(N,N-dimethylamino)-ethoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is H, X is S, R1 is ethoxy, R2 is
2-methyl-phenylmethoxy, R3 is H, L is absent, and B is H; a compound
of Formula (Ia) wherein A is benzo, W is C(R4), R4 is H, X is
S, R1 is ethoxy, R2 is 2-chloro-phenylmethoxy, R3 is H, L
is absent, and B is H; a compound of Formula (Ia) wherein A is benzo, W
is C(R4), R4 is methyl, X is S, R1 is ethoxy, R2 is
methyl, R3 is H, L is CH2, and B is 3,4-difluoro-phenyl; a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
H, X is S, R1 is ethoxy, R2 is 4-fluoro-phenylmethoxy, R3
is H, L is absent, and B is H; a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is H, X is S, R1 is ethoxy, R2
is 2-fluoro-phenylmethoxy, R3 is H, L is absent, and B is H; a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
H, X is S, R1 is ethoxy, R2 is 2-bromo-phenylmethoxy, R3
is H, L is absent, and B is H; a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is H, X is S, R1 is ethoxy, R2
is phenylmethoxy, R3 is H, L is absent, and B is H; a compound of
Formula (Ia) wherein A is benzo, W is C(R4), R4 is H, X is S,
R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B
is 5-chloro-benzo[1,3]dioxol-6-yl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is methyl, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
2,5-di-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein A is
benzo, W is C(R4), X is S, R4 is N,N-dimethylamino-methyl,
R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B
is 2-fluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is methyl, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 2-biphenyl; a compound of
Formula (Ia) wherein A is 7-trifluoromethyl-benzo, W is C(R4),
R4 is methyl, X is S, R1 is ethoxy, R2 is ethoxy, R3
is H, L is CH2, and B is 3,4-difluoro-phenyl; a compound of Formula
(Ia) wherein A is 6-chloro-benzo, W is C(R4), R4 is
cyclopentyl, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H,
L is CH2, and B is 3,4-difluoro-phenyl; a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is methyl, X is S(O),
R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B
is 3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W
is C(R4), R4 is cyclohexyl, X is S, R1 is ethoxy, R2
is ethoxy, R3 is H, L is CH2, and B is 3,4-difluoro-phenyl; a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
H, X is O, R1 is isopropyloxy, R2 is isopropyloxy, R3 is
H, L is CH2, and B is 3,4-difluoro-phenyl; a compound of Formula
(Ia) wherein A is benzo, W is C(R4), R4 is H, X is S, R1
is isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2,
and B is 3,5-difluoro-phenyl; a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is H, X is S, R1 is isopropyloxy,
R2 is isopropyloxy, R3 is H, L is CH2, and B is
2,3-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is bromo, X is O, R1 is isobutyl, R2 is
isobutyl, R3 is H, L is CH2, and B is 3,4-difluoro-phenyl; a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
bromo, X is O, R1 is isopropyloxy, R2 is isopropyloxy, R3
is H, L is CH2, and B is 3,4-difluoro-phenyl; a compound of Formula
(Ia) wherein A is benzo, W is C(R4), R4 is H, X is S, R1
is isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2,
and B is 3-trifluoromethyl-4-fluoro-phenyl; a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is H, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 2-fluoro-3-chloro-5-trifluoromethyl-phenyl; a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is 2-fluoro-pyridin-3-yl, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is 2,2-dimethyl-propyl, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is 2-fluoro-pyridin-5-yl, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is
(2,3-b)pyridin-2-yl, W is C(R4), R4 is H, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is
(2,3-b)pyridin-2-yl, W is C(R4), R4 is bromo, X is S, R1
is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is H, X is S, R1 is isopropyloxy, R2 is
isopropyloxy, R3 is H, L is CH2, and B is 3-fluoro-phenyl; a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
H, X is S, R1 is isopropyloxy, R2 is isopropyloxy, R3 is
H, L is CH2, and B is 3-chloro-phenyl; diastereomer A, a compound of
Formula (Ia) wherein A is benzo, W is C(R4), R4 is methyl, X is
S, R1 is ethoxy, R2 is 3-(4-methoxy-phenyl)-propyl, R3 is
H, L is CH2, and B is 3,4-difluoro-phenyl; diastereomer B, a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
methyl, X is S, R1 is ethoxy, R2 is
3-(4-methoxy-phenyl)-propyl, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is bromo, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 3-chloro-phenyl; a compound
of Formula (Ia) wherein A is benzo, W is C(R4), R4 is bromo, X
is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2,
and B is 4-fluoro-3-trimethyl-phenyl; a compound of Formula (Ia) wherein
A is benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
4-chloro-3-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3-fluoro-5-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein A is benzo,
W is C(R4), R4 is bromo, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is
2-fluoro-3-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
2-fluoro-3-chloro-phenyl; a compound of Formula (Ia) wherein A is benzo,
W is C(R4), R4 is bromo, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is
3-fluoro-4-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3-trifluoromethoxy-phenyl; a compound of Formula (Ia) wherein A is benzo,
W is C(R4), R4 is bromo, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is
2-fluoro-5-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is 2-chloro-phenyl;
a compound of Formula (Ia) wherein A is benzo, W is C(R4), R4
is bromo, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L
is CH2, and B is 2-chloro-5-trifluoromethyl-phenyl; a compound of
Formula (Ia) wherein A is benzo, W is C(R4), R4 is bromo, X is
S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and
B is 3-chloro-4-trifluoromethoxy-phenyl; a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
2-fluoro-4-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
2-chloro-3-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3-trifluoromethyl-4-methoxy-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
4-trifluoromethylthio-phenyl; a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
4-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein A is benzo,
W is C(R4), R4 is bromo, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 4-trifluoromethoxy-phenyl;
a compound of Formula (Ia) wherein A is benzo, W is C(R4), R4
is bromo, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L
is CH2, and B is 3-methoxy-4-fluoro-phenyl; a compound of Formula
(Ia) wherein A is benzo, W is C(R4), R4 is bromo, X is S,
R1 is isopropyloxy, R2 is isopropyloxy, R3 is H, L is
CH2, and B is 3-methoxy-4-fluoro-phenyl; a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
ethoxy, R2 is ethoxy, R

3 is H, L is CH2, and B is 3-fluoro-4-methoxy-phenyl; a compound
of Formula (Ia) wherein A is benzo, W is C(R4), R4 is bromo, X
is S, R1 is isopropyloxy, R2 is isopropyloxy, R3 is H, L
is CH2, and B is 3-fluoro-4-methoxy-phenyl; a compound of Formula
(Ia) wherein A is benzo, W is C(R4), R4 is bromo, X is S,
R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B
is 2,3,5,6-tetrafluoro-4-methoxy-phenyl; a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 2,3,5,6-tetrafluoro-4-methoxy-phenyl; a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
2-fluoro-3-methoxy-phenyl; a compound of Formula (Ia) wherein A is benzo,
W is C(R4), R4 is bromo, X is S, R1 is isopropyloxy,
R2 is isopropyloxy, R3 is H, L is CH2, and B is
2-fluoro-4-methoxy-phenyl; a compound of Formula (Ia) wherein A is benzo,
W is C(R4), R4 is bromo, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is
2-fluoro-4-chloro-5-methoxy-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 2-fluoro-4-chloro-5-methoxy-phenyl; a compound of Formula (Ia) wherein
A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3-chloro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is chloro, X is S, R1 is isopropyloxy, R2
is isopropyloxy, R3 is H, L is CH2, and B is
3-trifluoromethyl-4-chloro-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is chloro, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 2-fluoro-3-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein
A is benzo, W is C(R4), R4 is chloro, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3-fluoro-5-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein
A is benzo, W is C(R4), R4 is chloro, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is chloro, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3,5-di-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is chloro, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 2-fluoro-5-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein
A is benzo, W is C(R4), R4 is chloro, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 2-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is chloro, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3-fluoro-4-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein
A is benzo, W is C(R4), R4 is chloro, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 4-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is chloro, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3-trifluoromethyl-4-methoxy-phenyl; a compound of Formula (Ia) wherein
A is benzo, W is C(R4), R4 is chloro, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 2-chloro-3-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein
A is benzo, W is C(R4), R4 is chloro, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 2-chloro-5-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein
A is benzo, W is C(R4), R4 is chloro, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is chloro, X is S, R1 is isopropyloxy, R2
is isopropyloxy, R3 is H, L is CH2, and B is 3-chloro-phenyl; a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
chloro, X is S, R1 is isopropyloxy, R2 is isopropyloxy, R3
is H, L is CH2, and B is 4-chloro-phenyl; a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is chloro, X is S, R1
is isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2,
and B is 3-bromo-phenyl; a compound of Formula (Ia) wherein A is benzo, W
is C(R4), R4 is chloro, X is S, R1 is isopropyloxy,
R2 is isopropyloxy, R3 is H, L is CH2, and B is
2,6-dichloro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is chloro, X is S, R1 is isopropyloxy, R2
is isopropyloxy, R3 is H, L is CH2, and B is
3-chloro-4-trifluoromethoxy-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is chloro, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 2-fluoro-3-chloro-phenyl; a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is chloro, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3-chloro-5-fluoro-phenyl; a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is chloro, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 4-trifluoromethoxy-phenyl; a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is chloro, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3-trifluoromethyl-4-fluoro-phenyl; a compound of Formula (Ia) wherein
A is benzo, W is C(R4), R4 is chloro, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3-fluoro-4-chloro-phenyl; a compound of Formula (Ia) wherein A is benzo,
W is C(R4), R4 is bromo, X is S, R1 is isopropyloxy,
R2 is isopropyloxy, R3 is H, L is CH2, and B is
3-fluoro-4-chloro-phenyl; a compound of Formula (Ia) wherein A is benzo,
W is C(R4), R4 is chloro, X is S, R1 is isopropyloxy,
R2 is isopropyloxy, R3 is H, L is CH2, and B is
2-fluoro-4-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3-fluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is bromo, X is S, R1 is isopropyloxy, R2 is
isopropyloxy, R3 is H, L is CH2, and B is 3,5-difluoro-phenyl;
a compound of Formula (Ia) wherein A is benzo, W is C(R4), R4
is bromo, X is S, R1 is isopropyloxy, R2 is isopropyloxy,
R3 is H, L is CH2, and B is 2,3-difluoro-phenyl; a compound of
Formula (Ia) wherein A is benzo, W is C(R4), R4 is bromo, X is
S, R1 is isopropyloxy, R2 is isopropyloxy, R3 is H, L is
CH2, and B is 2-fluoro-3-chloro-5-trifluoromethyl-phenyl; a compound
of Formula (Ia) wherein A is benzo, W is C(R4), R4 is bromo, X
is S, R1 is isopropyloxy, R2 is isopropyloxy, R3 is H, L
is CH2, and B is 2-fluoro-phenyl; a compound of Formula (Ia) wherein
A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 4-fluoro-phenyl; a compound of Formula (Ia) wherein A is
4-bromo-benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 2-fluoro-phenyl; a compound of Formula (Ia) wherein A is
6-bromo-benzyl, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 2-fluoro-phenyl; a compound of Formula (Ia) wherein A is
6-bromo-benzyl, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 4-fluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is bromo, X is S, R1 is methoxy, R2 is
methoxy, R3 is H, L is CH2, and B is 3,4-difluoro-phenyl; a
compound of Formula (Ia) wherein A is 4-fluoro-benzo, W is C(R4),
R4 is methyl, X is O, R1 is isopropyloxy, R2 is
isopropyloxy, R3 is H, L is CH2, and B is 3,4-difluoro-phenyl;
a compound of Formula (Ia) wherein A is benzo, W is C(R4), R4
is bromo, X is S, R1 is s-butyl, R2 is s-butyl, R3 is H, L
is CH2, and B is 3,4-difluoro-phenyl; a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
s-butyl, R2 is s-butyl, R3 is H, L is OCH2, and B is
3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is
4-fluoro-benzo, W is C(R4), R4 is bromo, X is O, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is
4-fluoro-benzo, W is C(R4), R4 is bromo, X is O, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is
(2,3-b)pyridin-2-yl, W is C(R4), R4 is bromo, X is S, R1
is isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2,
and B is 3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is thien-3-yl, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is bromo, X is S, R1 is n-butyloxy, R2 is
n-butyloxy, R3 is H, L is CH2, and B is 3,4-difluoro-phenyl; a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
bromo, X is S, R1 is 2-(2-methoxy-ethoxy)-ethoxy, R2 is
2-(2-methoxy-ethoxy)-ethoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is bromo, X is S, R1 is 3-methyl-butoxy, R2
is 3-methyl-butoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is bromo, X is S, R1 is methoxycarbonyl-methoxy,
R2 is methoxycarbonyl-methoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is bromo, X is S, R1 is 2-acetoxy-ethoxy,
R2 is 2-acetoxy-ethoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is phenyl, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 3,4-difluoro-phenyl; a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
2-hydroxy-phenyl, X is S, R1 is ethoxy, R2 is ethoxy, R3
is H, L is CH2, and B is 3,4-difluoro-phenyl; a compound of Formula
(Ia) wherein A is benzo, W is C(R4), R4 is 2-fluoro-phenyl, X
is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2,
and B is 3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is 3-fluoro-phenyl, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is 3-aminocarbonyl-phenyl, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is 3-methoxycarbonyl-phenyl, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is 4-fluoro-phenyl, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is
4-fluoro-benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is
4-fluoro-benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3-trifluoromethyl-4-fluoro-phenyl; a compound of Formula (Ia) wherein
A is 4-fluoro-benzo, W is C(R4), R4 is bromo, X is S, R1
is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3-trifluoromethyl-4-fluoro-phenyl; a compound of Formula (Ia) wherein A
is 4-fluoro-benzo, W is C(R4), R4 is bromo, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is bromo, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 3-hydroxy-4-fluoro-phenyl;
a compound of Formula (Ia) wherein A is benzo, W is C(R4), R4
is bromo, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L
is CH2, and B is 3-fluoro-4-hydroxy-phenyl; a compound of Formula
(Ia) wherein A is benzo, W is C(R4), R4 is bromo, X is S,
R1 is isopropyloxy, R2 is isopropyloxy, R3 is H, L is
CH2, and B is 3-fluoro-4-hydroxy-phenyl; a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
2,3,5,6-tetrafluoro-4-hydroxy-phenyl; a compound of Formula (Ia) wherein
A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 2,3,5,6-tetrafluoro-4-hydroxy-phenyl; a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 2-fluoro-3-hydroxy-phenyl; a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
2-fluoro-4-chloro-5-hydroxy-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R

4), R4 is bromo, X is S, R1 is isopropyloxy, R2 is
isopropyloxy, R3 is H, L is CH2, and B is
2-fluoro-4-chloro-5-hydroxy-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3-trifluoromethyl-4-hydroxy-phenyl; enantiomer A, a compound of Formula
(Ia) wherein A is benzo, W is C(R4), R4 is bromo, X is S,
R1 is isopropyloxy, R2 is isopropyloxy, R3 is H, L is
CH2, and B is 3,4-difluoro-phenyl; enantiomer B, a compound of
Formula (Ia) wherein A is benzo, W is C(R4), R4 is bromo, X is
S, R1 is isopropyloxy, R2 is isopropyloxy, R3 is H, L is
CH2, and B is 3,4-difluoro-phenyl; enantiomer A, a compound of
Formula (Ia) wherein A is benzo, W is C(R4), R4 is bromo, X is
S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and
B is 4-trifluoromethoxy-phenyl; enantiomer B, a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
4-trifluoromethoxy-phenyl; a compound of Formula (Ia) wherein A is benzo,
W is C(R4), R4 is bromo, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 4-fluoro-phenyl; enantiomer
A, a compound of Formula (Ia) wherein A is benzo, W is C(R4),
R4 is bromo, X is S, R1 is ethoxy, R2 is ethoxy, R3
is H, L is CH2, and B is 4-fluoro-phenyl; enantiomer B, a compound
of Formula (Ia) wherein A is benzo, W is C(R4), R4 is bromo, X
is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2,
and B is 4-fluoro-phenyl; a compound of Formula (Ia) wherein A is benzo,
W is C(R4), R4 is bromo, X is S, R1 is isopropyloxy,
R2 is isopropyloxy, R3 is H, L is CH2, and B is
3-trifluoromethyl-4-fluoro-phenyl; enantiomer A, a compound of Formula
(Ia) wherein A is benzo, W is C(R4), R4 is bromo, X is S,
R1 is isopropyloxy, R2 is isopropyloxy, R3 is H, L is
CH2, and B is 3-trifluoromethyl-4-fluoro-phenyl; enantiomer B, a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
bromo, X is S, R1 is isopropyloxy, R2 is isopropyloxy, R3
is H, L is CH2, and B is 3-trifluoromethyl-4-fluoro-phenyl; a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
bromo, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is
CH2, and B is 3-chloro-4-fluoro-phenyl; a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
2-trifluoromethyl-4-fluoro-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3-trimethylthio-phenyl; a compound of Formula (Ia) wherein A is benzo, W
is C(R4), R4 is bromo, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 4-methylthio-phenyl; a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
bromo, X is S, R1 is isopropyloxy, R2 is isopropyloxy, R3
is H, L is CH2, and B is 3-chloro-4-fluoro-phenyl; a compound of
Formula (Ia) wherein A is benzo, W is C(R4), R4 is bromo, X is
S, R1 is isopropyloxy, R2 is isopropyloxy, R3 is H, L is
CH2, and B is 2-trifluoromethyl-4-fluoro-phenyl; a compound of
Formula (Ia) wherein A is benzo, W is C(R4), R4 is bromo, X is
S, R1 is isopropyloxy, R2 is isopropyloxy, R3 is H, L is
CH2, and B is 3-trifluoromethylthio-phenyl; a compound of Formula
(Ia) wherein A is benzo, W is C(R4), R4 is bromo, X is S,
R1 is isopropyloxy, R2 is isopropyloxy, R3 is H, L is
CH2, and B is 4-methylthio-phenyl; a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 4-methylsulfonyl-phenyl; a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is chloro, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3-chloro-4-fluoro-phenyl; a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is chloro, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 2-trifluoromethyl-4-fluoro-phenyl; a compound of Formula (Ia) wherein
A is benzo, W is C(R4), R4 is chloro, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3-trifluoromethylthio-phenyl; a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is chloro, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 4-methylthio-phenyl; a compound of Formula (Ia) wherein A is benzo, W
is C(R4), R4 is bromo, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 4-chloro-phenyl; a compound
of Formula (Ia) wherein A is benzo, W is C(R4), R4 is bromo, X
is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2,
and B is 3-fluoro-4-chloro-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3-chloro-5-fluoro-phenyl; a compound of Formula (Ia) wherein A is benzo,
W is C(R4), R4 is bromo, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 2-trifluoromethyl-phenyl; a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
bromo, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is
CH2, and B is 3,5-di-trifluoromethyl-phenyl; a compound of Formula
(Ia) wherein A is benzo, W is C(R4), R4 is bromo, X is S,
R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B
is 4-trifluoromethylsulfonyl-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 4-trifluoromethylsulfonyl-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is chloro, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 4-trifluoromethylsulfonyl-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is H, X is O, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is bromo, X is O, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 3,4-difluoro-phenyl; a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
bromo, X is S, R1 is isopropyloxy, R2 is isopropyloxy, R3
is H, L is CH2, and B is 3-chloro-2-fluoro-phenyl; a compound of
Formula (Ia) wherein A is benzo, W is C(R4), R4 is bromo, X is
S, R1 is isopropyloxy, R2 is isopropyloxy, R3 is H, L is
CH2, and B is 2-chloro-3-trifluoromethyl-phenyl; a compound of
Formula (Ia) wherein A is benzo, W is C(R4), R4 is chloro, X is
S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and
B is 2-chloro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is chloro, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 3-trifluoromethoxy-phenyl;
a compound of Formula (Ia) wherein A is benzo, W is C(R4), R4
is chloro, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L
is CH2, and B is 3-chloro-4-trifluoromethoxy-phenyl; a compound of
Formula (Ia) wherein A is benzo, W is C(R4), R4 is chloro, X is
S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and
B is 3-chloro-2-fluoro-phenyl; a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is chloro, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3-fluoro-4-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is chloro, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
2-chloro-5-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is chloro, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is 3-bromo-phenyl;
a compound of Formula (Ia) wherein A is benzo, W is C(R4), R4
is chloro, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L
is CH2, and B is 3-chloro-5-fluoro-phenyl; a compound of Formula
(Ia) wherein A is benzo, W is C(R4), R4 is chloro, X is S,
R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B
is 4-trifluoromethoxy-phenyl; a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is chloro, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3-fluoro-5-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is chloro, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
2-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein A is benzo,
W is C(R4), R4 is chloro, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is
2-chloro-3-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is chloro, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
2-fluoro-3-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is chloro, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3,5-di-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is chloro, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
4-trifluoromethylthio-phenyl; a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is chloro, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is 4-fluoro-phenyl;
a compound of Formula (Ia) wherein A is benzo, W is C(R4), R4
is chloro, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L
is CH2, and B is 4-trifluoromethyl-phenyl; a compound of Formula
(Ia) wherein A is benzo, W is C(R4), R4 is chloro, X is S,
R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B
is 2-fluoro-5-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein
A is benzo, W is C(R4), R4 is chloro, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
4-chloro-3-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 4-chloro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is bromo, X is S, R1 is isopropyloxy, R2 is
isopropyloxy, R3 is H, L is CH2, and B is
2-fluoro-4-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is chloro, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is 3-chloro-phenyl;
a compound of Formula (Ia) wherein A is benzo, W is C(R4), R4
is chloro, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L
is CH2, and B is 2-fluoro-4-trifluoromethyl-phenyl; a compound of
Formula (Ia) wherein A is benzo, W is C(R4), R4 is chloro, X is
S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and
B is 4-methoxy-3-trifluoromethyl-phenyl; a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is chloro, X is S, R1
is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
4-chloro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is chloro, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is
4-fluoro-3-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is 3-bromo-phenyl;
a compound of Formula (Ia) wherein A is benzo, W is C(R4), R4
is chloro, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L
is CH2, and B is 3-trifluoromethylthio-phenyl; a compound of Formula
(Ia) wherein A is benzo, W is C(R4), R4 is chloro, X is S,
R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B
is 3-chloro-4-fluoro-phenyl; a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is chloro, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
4-fluoro-3-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is chloro, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
4-methylthio-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is chloro, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is
4-trifluoromethylsulfonyl-phenyl; a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is chloro, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3-trifluoromethoxy-phenyl; a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is chloro, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 4-chloro-3-fluoro-phenyl; a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is chloro, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 5-chloro-2-fluoro-phenyl; a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is chloro, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 4-trifluoromethylthio-phenyl; a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is chloro, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
5-chloro-2-fluoro-phenyl; a compound of Formula (Ia) wherein A is benzo,
W is C(R4), R4 is chloro, X is S, R1 is isopropyloxy,
R2 is isopropyloxy, R3 is H, L is CH2, and B is
4-fluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is bromo, X is S, R

1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
5-chloro-2-fluoro-phenyl; a compound of Formula (Ia) wherein A is benzo,
W is C(R4), R4 is bromo, X is S, R1 is isopropyloxy,
R2 is isopropyloxy, R3 is H, L is CH2, and B is
5-chloro-2-fluoro-phenyl; a compound of Formula (Ia) wherein A is benzo,
W is C(R4), R4 is bromo, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 3-cyano-phenyl; a compound
of Formula (Ia) wherein A is benzo, W is C(R4), R4 is bromo, X
is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2,
and B is 3-pyrrol-1-yl-phenyl; a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
4-difluoromethoxy-phenyl; a compound of Formula (Ia) wherein A is benzo,
W is C(R4), R4 is bromo, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 4-cyano-phenyl; a compound
of Formula (Ia) wherein A is benzo, W is C(R4), R4 is bromo, X
is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2,
and B is 3-methoxycarbonyl-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3-methoxy-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is bromo, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 3-nitro-phenyl; a compound
of Formula (Ia) wherein A is benzo, W is C(R4), R4 is bromo, X
is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2,
and B is 3-hydroxy-phenyl; a compound of Formula (Ia) wherein A is benzo,
W is C(R4), R4 is bromo, X is S, R1 is isopropyloxy,
R2 is isopropyloxy, R3 is H, L is CH2, and B is
3-methoxy-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is bromo, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 3-amino-phenyl; a compound
of Formula (Ia) wherein A is benzo, W is C(R4), R4 is bromo, X
is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2,
and B is 3,5-dimethoxy-phenyl; a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
2-methoxy-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is bromo, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 4-methoxy-phenyl; a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
bromo, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is
CH2, and B is 3,5-dihydroxy-phenyl; a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
2-hydroxy-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is bromo, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 4-hydroxy-phenyl; a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
bromo, X is S, R1 is isopropyloxy, R2 is isopropyloxy, R3
is H, L is CH2, and B is 3-hydroxy-phenyl; a compound of Formula
(Ia) wherein A is benzo, W is C(R4), R4 is bromo, X is S,
R1 is isopropyloxy, R2 is isopropyloxy, R3 is H, L is
CH2, and B is 4-methoxy-3-trifluoromethyl-phenyl; a compound of
Formula (Ia) wherein A is benzo, W is C(R4), R4 is bromo, X is
N(t-butoxycarbonyl), R1 is isopropyloxy, R2 is isopropyloxy,
R3 is H, L is CH2, and B is 4-fluoro-3-trifluoromethyl-phenyl;
a compound of Formula (Ia) wherein A is benzo, W is C(R4), R4
is bromo, X is N(methyl), R1 is isopropyloxy, R2 is
isopropyloxy, R3 is H, L is CH2, and B is
4-fluoro-3-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein A
is 3-trifluoromethyl-4-fluoro-benzo, W is C(R4), R4 is bromo, X
is N(n-propyl), R1 is isopropyloxy, R2 is isopropyloxy, R3
is H, L is CH2, and B is 4-fluoro-3-trifluoromethyl-phenyl; a
compound of Formula (Ia) wherein A is 3-trifluoromethyl-4-fluoro-benzo, W
is C(R4), R4 is bromo, X is N(methanesulfonyl), R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 4-fluoro-3-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein
A is benzo, W is C(R4), R4 is bromo, X is N(methylcarbonyl),
R1 is isopropyloxy, R2 is isopropyloxy, R3 is H, L is
CH2, and B is 4-fluoro-3-trifluoromethyl-phenyl; a compound of
Formula (Ia) wherein A is benzo, W is C(R4), R4 is bromo, X is
N(n-propylsulfonyl), R1 is isopropyloxy, R2 is isopropyloxy,
R3 is H, L is CH2, and B is 4-fluoro-3-trifluoromethyl-phenyl;
a compound of Formula (Ia) wherein A is benzo, W is C(R4), R4
is H, X is S, R1 is isopropyloxy, R2 is isopropyloxy, R3
is absent, L is ═CH-- taken to form an alkene with the
phosphorus-bearing adjacent atom, and B is 3,4-difluoro-phenyl; a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
bromo, X is S, R1 is isopropyloxy, R2 is isopropyloxy, R3
is absent, L is ═CH-- taken to form an alkene with the
phosphorus-bearing adjacent atom, and B is 3,4-difluoro-phenyl; a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
bromo, X is S, R1 is isopropyloxy, R2 is isopropyloxy, R3
is H, L is CH2, and B is 2-fluoro-5-trifluoromethyl-phenyl; and a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
bromo, X is S, R1 is isopropyloxy, R2 is isopropyloxy, R3
is H, L is CH2, and B is 4-trifluoromethyl-phenyl.

39. A compound of Formula (Ia) ##STR00076## selected from the group
consisting of a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is methyl, X is S, R1 is isopropyloxy, R2
is isopropyloxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is i-propyl, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 3,4-difluoro-phenyl; a
compound of Formula (Ia) wherein A is 4-fluoro-benzo, W is C(R4),
R4 is methyl, X is S, R1 is ethoxy, R2 is ethoxy, R3
is H, L is CH2, and B is 3,4-difluoro-phenyl; a compound of Formula
(Ia) wherein A is benzo, W is C(R4), R4 is methyl, X is S,
R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B
is 3-chloro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is cyclopentyl, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 3,4-difluoro-phenyl; a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
methyl, X is S, R1 is ethoxy, R2 is isobutyl, R3 is H, L
is CH2, and B is 3,4-difluoro-phenyl; a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is methyl, X is S, R1
is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3-fluoro-phenyl; a compound of Formula (Ia) wherein A is 7-fluoro-benzo,
W is C(R4), R4 is methyl, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 3,4-difluoro-phenyl; a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
methyl, X is O, R1 is ethoxy, R2 is ethoxy, R3 is H, L is
CH2, and B is 3,4-difluoro-phenyl; a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is methyl, X is S, R1
is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
2,3-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is methyl, X is O, R1 is isopropyloxy, R2
is isopropyloxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is chloro, X is S, R1 is isopropyloxy, R2
is isopropyloxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is methyl, X is S, R1 is isobutyl, R2 is
isobutyl, R3 is H, L is OCH2, and B is 3,4-difluoro-phenyl; a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
methyl, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is
CH2, and B is 3,4-difluoro-phenyl; a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is
6-fluoro-benzo, W is C(R4), R4 is methyl, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is methyl, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 3,5-difluoro-phenyl; a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
methyl, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is
CH2, and B is 3-methyl-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is i-propyl, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W
is C(R4), R4 is cyclopropyl, X is S, R1 is isopropyloxy,
R2 is isopropyloxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is methyl, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 3,4-dichloro-phenyl; a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
methyl, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is
CH2, and B is 2-fluoro-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is methyl, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
2-fluoro-3-chloro-phenyl; a compound of Formula (Ia) wherein A is benzo,
W is C(R4), R4 is bromo, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 3,4-dichloro-phenyl; a
compound of Formula (Ia) wherein A is benzo, W is N, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W
is C(R4), R4 is methyl, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 2-methyl-phenyl; a compound
of Formula (Ia) wherein A is benzo, W is C(R4), R4 is methyl, X
is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2,
and B is 2-chloro-4-fluoro-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is methyl, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
2-chloro-3,5-difluoro-phenyl; a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is cyclopropyl, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is methyl, X is S, R1 is ethoxy, R2 is
methyl, R3 is H, L is CH2, and B is 3,4-difluoro-phenyl; a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
methyl, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is
CH2, and B is 3-trifluoromethyl-4-fluoro-phenyl; a compound of
Formula (Ia) wherein A is benzo, W is C(R4), R4 is methyl, X is
S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and
B is 3-methoxy-phenyl; a compound of Formula (Ia) wherein A is benzo, W
is C(R4), R4 is methyl, X is S, R1 is isobutyl, R2 is
isobutyl, R3 is H, L is CH2, and B is 3,4-difluoro-phenyl; a
compound of Formula (Ia) wherein A is (2,3-b)pyridin-2-yl, W is
C(R4), R4 is methyl, X is S, R1 is isopropyloxy, R2
is isopropyloxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is methyl, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 2,3-dichloro-phenyl; a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
methyl, X is S, R1 is ethoxy, R2 is isobutyl, R3 is H, L
is CH2, and B is 3,4-difluoro-phenyl; a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is methyl, X is S, R1
is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
2-fluoro-3-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is cyclopentyl, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W
is C(R4), R4 is H, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 3-trifluoromethyl-phenyl; a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
methyl, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is
CH2, and B is 3-bromo-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is cyclobutyl, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is methyl, X is S, R1 is n-propyl, R2 is
n-propyl, R3 is H, L is OCH2, and B is 3,4-difluoro-phenyl; a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
trifluoromethyl, X is S, R1 is isopropyloxy, R2 is
isopropyloxy, R3 is H, L is CH2, and B is 3,4-difluoro-phenyl;
a compound of Formula (Ia) wherein A is benzo, W is C(R4), R4
is methyl, X is S, R1 is n-propyl, R2 is n-propyl, R3 is
H, L is CH2, and B is 3,4-difluoro-phenyl; a compound of Formula
(Ia) wherein A is 5-fluoro-benzo, W is C(R4), R4 is methyl, X
is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2,
and B is 3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is methyl, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is naphthalen-2-yl;
a compound of Formula (Ia) wherein A is benzo, W is C(R4), R4
is methyl, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L
is CH2, and B is 2,5-dichloro-phenyl; a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is methyl, X is S, R1
is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
2-chloro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is methyl, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is
3-trifluoromethyl-4-chloro-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is methyl, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is 4-fluoro-phenyl;
a compound of Formula (Ia) wherein A is benzo, W is C(R4), R4
is H, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is
CH2, and B is 4-fluoro-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is methyl, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein A is benzo,
W is C(R4), R4 is methyl, X is S, R1 is
2,2-dimethyl-propyl, R2 is 2,2-dimethyl-propyl, R3 is H, L is
CH2, and B is 3,4-difluoro-phenyl; a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is methyl, X is S, R1
is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
2,6-dichloro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is methyl, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 4-trifluoromethoxy-phenyl;
a compound of Formula (Ia) wherein A is benzo, W is C(R4), R4
is methyl, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L
is CH2, and B is 3-fluoro-5-trifluoromethyl-phenyl; a compound of
Formula (Ia) wherein A is benzo, W is C(R4), R4 is methyl, X is
S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and
B is 3-trifluoromethoxy-phenyl; a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is H, X is S, R1 is ethoxy, R2
is ethoxy, R3 is H, L is CH2, and B is
3-fluoro-4-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is methyl, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
2-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein A is benzo,
W is C(R4), R4 is methyl, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is
2-fluoro-3-methyl-6-chloro-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is methyl, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
2-trifluoromethoxy-phenyl; a compound of Formula (Ia) wherein A is
5-methyl-benzo, W is C(R4), R4 is methyl, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W
is C(R4), R4 is H, X is S, R1 is isopropyloxy, R2 is
isopropyloxy, R3 is H, L is CH2, and B is 3,4-difluoro-phenyl;
a compound of Formula (Ia) wherein A is benzo, W is C(R4), R4
is phenyl, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L
is CH2, and B is 3,4-dichloro-phenyl; a compound of Formula (Ia)
wherein A is 4-chloro-benzo, W is C(R4), R4 is methyl, X is S,
R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B
is 3,4-dichloro-phenyl; a compound of Formula (Ia) wherein A is benzo, W
is C(R4), R4 is methyl, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 2-bromo-phenyl; a compound
of Formula (Ia) wherein A is benzo, W is C(R4), R4 is methyl, X
is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2,
and B is 2-fluoro-5-trifluoromethyl-phenyl; a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is H, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
4-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein A is benzo,
W is C(R4), R4 is H, X is S, R1 is isopropyloxy, R2
is isopropyloxy, R3 is H, L is CH2, and B is
3-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein A is benzo,
W is C(R4), R4 is H, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 4-bromo-phenyl; a compound
of Formula (Ia) wherein A is benzo, W is C(R4), R4 is methyl, X
is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2,
and B is 5-chloro-benzo[1,3]dioxol-6-yl; a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is methyl, X is S, R1
is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3-(pyridin-4-yl)-phenyl; a compound of Formula (Ia) wherein A is benzo, W
is C(R4), R4 is methyl, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is
2-fluoro-3-chloro-5-trifluoromethyl-phenyl; a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is H, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is phenyl;
a compound of Formula (Ia) wherein A is benzo, W is C(R4), R4
is H, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is
CH2, and B is 3,4-difluoro-phenyl; a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is methyl, X is S, R1
is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
2,4-dichloro-5-fluoro-phenyl; a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is methyl, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is 3-biphenyl; a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
H, X is S, R

1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-dichloro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is methyl, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is CH3, L is CH2, and B is 3,4-difluoro-phenyl;
a compound of Formula (Ia) wherein A is benzo, W is C(R4), R4
is H, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is
CH2, and B is 2-fluoro-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is methyl, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
2-chloro-3-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein A
is 6-methoxy-benzo, W is C(R4), R4 is methyl, X is S, R1
is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is H, X is S, R1 is ethoxy, R2 is ethoxy,
R3 is H, L is CH2, and B is naphthalen-2-yl; a compound of
Formula (Ia) wherein A is 4-trifluoromethyl-benzo, W is C(R4),
R4 is methyl, X is S, R1 is ethoxy, R2 is ethoxy, R3
is H, L is CH2, and B is 3,4-difluoro-phenyl; a compound of Formula
(Ia) wherein A is benzo, W is C(R4), R4 is H, X is S, R1
is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
2-chloro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is H, X is O, R1 is ethoxy, R2 is ethoxy,
R3 is H, L is CH2, and B is 4-fluoro-phenyl; a compound of
Formula (Ia) wherein A is benzo, W is C(R4), R4 is methyl, X is
SO2, R1 is ethoxy, R2 is ethoxy, R3 is H, L is
CH2, and B is 3,4-difluoro-phenyl; a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is H, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
2-methyl-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is H, X is S, R1 is ethoxy, R2 is ethoxy,
R3 is H, L is CH2, and B is benzothiophen-2-yl; a compound of
Formula (Ia) wherein A is benzo, W is C(R4), R4 is methyl, X is
S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and
B is 4-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein A is
5-chloro-benzo, W is C(R4), R4 is methyl, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W
is C(R4), R4 is bromo, X is S, R1 is isopropyloxy, R2
is isopropyloxy, R3 is bromo, L is CH2, and B is
3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is H, X is S, R1 is ethoxy, R2 is
2,6-dichloro-phenylmethoxy, R3 is H, L is absent, and B is H; a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
H, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is
CH2, and B is 2,6-dichloro-phenyl; a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is H, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3,5-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is H, X is S, R1 is ethoxy, R2
is ethoxy, R3 is H, L is CH2, and B is
2-chloro-4-fluoro-phenyl; a compound of Formula (Ia) wherein A is benzo,
W is C(R4), R4 is methyl, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is
2-chloro-5-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is H, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
2,3-dichloro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is methyl, X is S, R1 is cyclohexyloxy, R2
is cyclohexyloxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is H, X is S, R1 is ethoxy, R2 is ethoxy,
R3 is H, L is CH2, and B is 2-trifluoromethyl-phenyl; a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
methyl, X is S, R1 is ethoxy, R2 is
2-(N,N-dimethylamino)-ethoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is H, X is S, R1 is ethoxy, R2 is
2-methyl-phenylmethoxy, R3 is H, L is absent, and B is H; a compound
of Formula (Ia) wherein A is benzo, W is C(R4), R4 is H, X is
S, R1 is ethoxy, R2 is 2-chloro-phenylmethoxy, R3 is H, L
is absent, and B is H; a compound of Formula (Ia) wherein A is benzo, W
is C(R4), R4 is methyl, X is S, R1 is ethoxy, R2 is
methyl, R3 is H, L is CH2, and B is 3,4-difluoro-phenyl; a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
H, X is S, R1 is ethoxy, R2 is 4-fluoro-phenylmethoxy, R3
is H, L is absent, and B is H; a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is H, X is S, R1 is ethoxy, R2
is 2-fluoro-phenylmethoxy, R3 is H, L is absent, and B is H; a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
bromo, X is S, R1 is isopropyloxy, R2 is isopropyloxy, R3
is H, L is CH2, and B is 3-methoxy-4-fluoro-phenyl; a compound of
Formula (Ia) wherein A is benzo, W is C(R4), R4 is bromo, X is
S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and
B is 2-hydroxy-phenyl; a compound of Formula (Ia) wherein A is benzo, W
is C(R4), R4 is bromo, X is S, R1 is isopropyloxy, R2
is isopropyloxy, R3 is H, L is and B is
3-trifluoromethyl-4-fluoro-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3-hydroxy-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is bromo, X is S, R1 is isopropyloxy, R2 is
isopropyloxy, R3 is H, L is CH2, and B is
2-fluoro-3-hydroxy-phenyl; a compound of Formula (Ia) wherein A is benzo,
W is C(R4), R4 is bromo, X is S, R1 is isopropyloxy,
R2 is isopropyloxy, R3 is H, L is CH2, and B is
5-chloro-2-fluoro-phenyl; a compound of Formula (Ia) wherein A is benzo,
W is C(R4), R4 is bromo, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 3-methoxy-4-fluoro-phenyl;
a compound of Formula (Ia) wherein A is benzo, W is C(R4), R4
is bromo, X is S, R1 is isopropyloxy, R2 is isopropyloxy,
R3 is H, L is CH2, and B is 3-chloro-phenyl; a compound of
Formula (Ia) wherein A is benzo, W is C(R4), R4 is bromo, X is
S, R1 is isopropyloxy, R2 is isopropyloxy, R3 is H, L is
CH2, and B is 2,3,5,6-tetrafluoro-4-methoxy-phenyl; a compound of
Formula (Ia) wherein A is benzo, W is C(R4), R4 is bromo, X is
S, R1 is isopropyloxy, R2 is isopropyloxy, R3 is H, L is
CH2, and B is 2-fluoro-4-methoxy-phenyl; a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3-chloro-4-fluoro-phenyl; a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 4-trifluoromethylsulfonyl-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3-methoxy-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is bromo, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 4-chloro-phenyl; a compound
of Formula (Ia) wherein A is benzo, W is C(R4), R4 is bromo, X
is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2,
and B is 3-chloro-5-fluoro-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3,5-dimethoxy-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is bromo, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 5-chloro-2-fluoro-phenyl; a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
bromo, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is
CH2, and B is 3-hydroxy-4-fluoro-phenyl; a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3-chloro-4-fluoro-phenyl; a compound of Formula (Ia) wherein A is benzo,
W is C(R4), R4 is bromo, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 4-trifluoromethyl-phenyl; a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
bromo, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is
CH2, and B is 2-methoxy-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is chloro, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 4-trifluoromethylthio-phenyl; a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is chloro, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 4-trifluoromethylsulfonyl-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W
is C(R4), R4 is bromo, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 3-methoxy-phenyl; a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
bromo, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is
CH2, and B is 3-bromo-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is chloro, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 2-fluoro-4-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein
A is 4-fluoro-benzo, W is C(R4), R4 is bromo, X is S, R1
is isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2,
and B is 3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3-hydroxy-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is bromo, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 2-fluoro-3-methoxy-phenyl;
a compound of Formula (Ia) wherein A is benzo, W is C(R4), R4
is bromo, X is S, R1 is isopropyloxy, R2 is isopropyloxy,
R3 is H, L is CH2, and B is 3-fluoro-4-chloro-phenyl; a
compound of Formula (Ia) wherein A is 4-fluoro-benzo, W is C(R4),
R4 is bromo, X is S, R1 is isopropyloxy, R2 is
isopropyloxy, R3 is H, L is CH2, and B is
3-trifluoromethyl-4-fluoro-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is chloro, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3-chloro-4-fluoro-phenyl; a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 2-chloro-3-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein
A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3-fluoro-4-methoxy-phenyl; a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is and B is 4-fluoro-phenyl; a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
bromo, X is S, R1 is isopropyloxy, R2 is isopropyloxy, R3
is H, L is CH2, and B is 3-trifluoromethyl-4-fluoro-phenyl; a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
bromo, X is S, R1 is isopropyloxy, R2 is isopropyloxy, R3
is H, L is CH2, and B is 3-fluoro-phenyl; a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is chloro, X is S, R1
is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3-chloro-4-fluoro-phenyl; a compound of Formula (Ia) wherein A is benzo,
W is C(R4), R4 is bromo, X is S, R1 is isopropyloxy,
R2 is isopropyloxy, R3 is H, L is CH2, and B is
2,3-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is bromo, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 3-nitro-phenyl; a compound
of Formula (Ia) wherein A is benzo, W is C(R4), R4 is bromo, X
is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2,
and B is 3-pyrrol-1-yl-phenyl; a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
4-methoxy-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is bromo, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is
4-trifluoromethylthio-phenyl; a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
4-fluoro-3-trimethyl-phenyl; a compound of Formula (Ia) wherein A is
4-fluoro-benzo, W is C(R4), R4 is bromo, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is bromo, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 4-fluoro-phenyl; a compound
of Formula (Ia) wherein A is benzo, W is C(R4), R4 is bromo, X
is S, R1 is isopropyloxy, R2 is isopropyloxy, R3 is H, L
is CH2, and B is 4-methylthio-phenyl; a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
ethoxy, R2 is ethoxy, R

3 is H, L is CH2, and B is 3-fluoro-4-chloro-phenyl; a compound
of Formula (Ia) wherein A is benzo, W is C(R4), R4 is bromo, X
is S, R1 is isopropyloxy, R2 is isopropyloxy, R3 is H, L
is CH2, and B is 4-fluoro-phenyl; a compound of Formula (Ia) wherein
A is benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
4-trifluoromethoxy-phenyl; a compound of Formula (Ia) wherein A is benzo,
W is C(R4), R4 is bromo, X is S, R1 is isopropyloxy,
R2 is isopropyloxy, R3 is H, L is CH2, and B is
3-chloro-2-fluoro-phenyl; a compound of Formula (Ia) wherein A is benzo,
W is C(R4), R4 is bromo, X is S, R1 is isopropyloxy,
R2 is isopropyloxy, R3 is H, L is CH2, and B is
3-trifluoromethylthio-phenyl; a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 2-fluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is chloro, X is S, R1 is isopropyloxy, R2
is isopropyloxy, R3 is H, L is CH2, and B is
5-chloro-2-fluoro-phenyl; a compound of Formula (Ia) wherein A is
4-fluoro-benzo, W is C(R4), R4 is bromo, X is O, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is
(2,3-b)pyridin-2-yl, W is C(R4), R4 is bromo, X is S, R1
is isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2,
and B is 3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is O, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W
is C(R4), R4 is bromo, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 3-trifluoromethyl-phenyl; a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
bromo, X is O, R1 is ethoxy, R2 is ethoxy, R3 is H, L is
CH2, and B is 3,4-difluoro-phenyl; a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is chloro, X is S, R1
is isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2,
and B is 3-chloro-5-fluoro-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 2-fluoro-4-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein
A is 4-fluoro-benzo, W is C(R4), R4 is bromo, X is S, R1
is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3-trifluoromethyl-4-fluoro-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
4-difluoromethoxy-phenyl; a compound of Formula (Ia) wherein A is
4-fluoro-benzo, W is C(R4), R4 is methyl, X is O, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W
is C(R4), R4 is bromo, X is S, R1 is isopropyloxy, R2
is isopropyloxy, R3 is H, L is CH2, and B is
2-trifluoromethyl-4-fluoro-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is chloro, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3-trifluoromethoxy-phenyl; a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
2-fluoro-3-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3-trifluoromethyl-4-methoxy-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3-fluoro-5-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is chloro, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 4-methylthio-phenyl; a compound of Formula (Ia) wherein A is benzo, W
is C(R4), R4 is chloro, X is S, R1 is isopropyloxy,
R2 is isopropyloxy, R3 is H, L is CH2, and B is
3-chloro-4-trifluoromethoxy-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is chloro, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3-trifluoromethylthio-phenyl; a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3-fluoro-4-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3,5-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W
is C(R4), R4 is bromo, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 3-fluoro-4-methoxy-phenyl;
a compound of Formula (Ia) wherein A is benzo, W is C(R4), R4
is bromo, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L
is CH2, and B is 3-chloro-4-trifluoromethoxy-phenyl; a compound of
Formula (Ia) wherein A is benzo, W is C(R4), R4 is bromo, X is
S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and
B is 2,3,5,6-tetrafluoro-4-methoxy-phenyl; a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
4-chloro-3-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 2-fluoro-3-chloro-5-trifluoromethyl-phenyl; a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is chloro, X is S, R1
is isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2,
and B is 4-trifluoromethoxy-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 2-fluoro-4-chloro-5-hydroxy-phenyl; a compound of Formula (Ia) wherein
A is benzo, W is C(R4), R4 is chloro, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3-trifluoromethyl-4-fluoro-phenyl; a compound of Formula (Ia) wherein
A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 4-chloro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is chloro, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 3-fluoro-4-chloro-phenyl; a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
bromo, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is
CH2, and B is 4-trifluoromethylsulfonyl-phenyl; a compound of
Formula (Ia) wherein A is benzo, W is C(R4), R4 is chloro, X is
S, R1 is isopropyloxy, R2 is isopropyloxy, R3 is H, L is
CH2, and B is 4-fluoro-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
2-fluoro-3-chloro-phenyl; a compound of Formula (Ia) wherein A is benzo,
W is C(R4), R4 is chloro, X is S, R1 is isopropyloxy,
R2 is isopropyloxy, R3 is H, L is CH2, and B is phenyl; a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
chloro, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is
CH2, and B is 5-chloro-2-fluoro-phenyl; a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
n-butyloxy, R2 is n-butyloxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is chloro, X is S, R1 is isopropyloxy, R2
is isopropyloxy, R3 is H, L is CH2, and B is
2-fluoro-3-chloro-phenyl; a compound of Formula (Ia) wherein A is benzo,
W is C(R4), R4 is chloro, X is S, R1 is isopropyloxy,
R2 is isopropyloxy, R3 is H, L is CH2, and B is
4-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein A is benzo,
W is C(R4), R4 is chloro, X is S, R1 is isopropyloxy,
R2 is isopropyloxy, R3 is H, L is CH2, and B is
3-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein A is benzo,
W is C(R4), R4 is bromo, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is
3,5-di-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is chloro, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3-bromo-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is chloro, X is S, R1 is isopropyloxy, R2
is isopropyloxy, R3 is H, L is CH2, and B is 3-chloro-phenyl; a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
chloro, X is S, R1 is isopropyloxy, R2 is isopropyloxy, R3
is H, L is CH2, and B is 2-fluoro-3-trifluoromethyl-phenyl; a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
bromo, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is
CH2, and B is 2-trifluoromethyl-phenyl; a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is chloro, X is S, R1
is isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2,
and B is 4-chloro-3-fluoro-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is chloro, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is 4-fluoro-phenyl;
a compound of Formula (Ia) wherein A is benzo, W is C(R4), R4
is chloro, X is S, R1 is isopropyloxy, R2 is isopropyloxy,
R3 is H, L is CH2, and B is 2-trifluoromethyl-4-fluoro-phenyl;
a compound of Formula (Ia) wherein A is benzo, W is C(R4), R4
is phenyl, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L
is CH2, and B is 3,4-difluoro-phenyl; a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
2-fluoro-4-chloro-5-methoxy-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3-methoxycarbonyl-phenyl; a compound of Formula (Ia) wherein A is benzo,
W is C(R4), R4 is 2-hydroxy-phenyl, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is chloro, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is
4-fluoro-3-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 4-methoxy-3-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein
A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 2-fluoro-4-chloro-5-methoxy-phenyl; a compound of Formula (Ia) wherein
A is benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is 3-cyano-phenyl;
a compound of Formula (Ia) wherein A is benzo, W is C(R4), R4
is chloro, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L
is CH2, and B is 4-trifluoromethylsulfonyl-phenyl; enantiomer B, a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
bromo, X is S, R1 is isopropyloxy, R2 is isopropyloxy, R3
is H, L is CH2, and B is 3-trifluoromethyl-4-fluoro-phenyl; a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
bromo, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is
CH2, and B is 4-cyano-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is chloro, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3-fluoro-4-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein
A is benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
2-fluoro-4-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is S, R1 is s-butyl,
R2 is s-butyl, R3 is H, L is OCH2, and B is
3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is bromo, X is S, R1 is 3-methyl-butoxy, R2
is 3-methyl-butoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is chloro, X is S, R1 is isopropyloxy, R2
is isopropyloxy, R3 is H, L is CH2, and B is
3-trifluoromethyl-4-chloro-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is chloro, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3-fluoro-5-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein
A is 4-fluoro-benzo, W is C(R4), R4 is bromo, X is O, R1
is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is bromo, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is
2-fluoro-5-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3-fluoro-4-chloro-phenyl; a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3-trimethylthio-phenyl; a compound of Formula (Ia) wherein A is benzo, W
is C(R

4), R4 is thien-3-yl, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 3,4-difluoro-phenyl; a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
chloro, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is
CH2, and B is 3-bromo-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is chloro, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3-chloro-4-trifluoromethoxy-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is chloro, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 2-fluoro-5-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein
A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is absent, L is ═CH--
taken to form an alkene with the phosphorus-bearing adjacent atom, and B
is 3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W
is C(R4), R4 is chloro, X is S, R1 is isopropyloxy,
R2 is isopropyloxy, R3 is H, L is CH2, and B is
4-chloro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is chloro, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 3-chloro-2-fluoro-phenyl; a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
chloro, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is
CH2, and B is 3-chloro-5-fluoro-phenyl; a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is chloro, X is S, R1
is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3-chloro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is chloro, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is
3-fluoro-4-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is chloro, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
4-trifluoromethoxy-phenyl; a compound of Formula (Ia) wherein A is benzo,
W is C(R4), R4 is chloro, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is
4-fluoro-3-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is S, R1 is
methoxycarbonyl-methoxy, R2 is methoxycarbonyl-methoxy, R3 is
H, L is CH2, and B is 3,4-difluoro-phenyl; a compound of Formula
(Ia) wherein A is benzo, W is C(R4), R4 is bromo, X is S,
R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B
is 3-trifluoromethoxy-phenyl; a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
2-chloro-3-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
4-methylthio-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is chloro, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 3-fluoro-4-chloro-phenyl; a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
bromo, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is
CH2, and B is 2-fluoro-4-chloro-5-hydroxy-phenyl; enantiomer A, a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
bromo, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is
CH2, and B is 4-trifluoromethoxy-phenyl; a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is chloro, X is S, R1
is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
4-chloro-3-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
2-trifluoromethyl-4-fluoro-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is 2-chloro-phenyl;
a compound of Formula (Ia) wherein A is benzo, W is C(R4), R4
is chloro, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L
is CH2, and B is 4-trifluoromethylthio-phenyl; a compound of Formula
(Ia) wherein A is benzo, W is C(R4), R4 is chloro, X is S,
R1 is isopropyloxy, R2 is isopropyloxy, R3 is H, L is
CH2, and B is 2-fluoro-4-trifluoromethyl-phenyl; a compound of
Formula (Ia) wherein A is benzo, W is C(R4), R4 is chloro, X is
S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and
B is 4-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is 2-fluoro-phenyl, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is chloro, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is
2-fluoro-5-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
2,3,5,6-tetrafluoro-4-hydroxy-phenyl; a compound of Formula (Ia) wherein
A is benzo, W is C(R4), R4 is chloro, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3-trifluoromethyl-4-methoxy-phenyl; a compound of Formula (Ia) wherein
A is benzo, W is C(R4), R4 is chloro, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 2,6-dichloro-phenyl; a compound of Formula (Ia) wherein A is benzo, W
is C(R4), R4 is chloro, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is
2-fluoro-3-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is S, R1 is methoxy,
R2 is methoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is
3-trifluoromethyl-4-fluoro-benzo, W is C(R4), R4 is bromo, X is
N(methanesulfonyl), R1 is isopropyloxy, R2 is isopropyloxy,
R3 is H, L is CH2, and B is 4-fluoro-3-trifluoromethyl-phenyl;
a compound of Formula (Ia) wherein A is benzo, W is C(R4), R4
is chloro, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L
is CH2, and B is 3-trifluoromethylthio-phenyl; a compound of Formula
(Ia) wherein A is benzo, W is C(R4), R4 is chloro, X is S,
R1 is isopropyloxy, R2 is isopropyloxy, R3 is H, L is
CH2, and B is 2-chloro-3-trifluoromethyl-phenyl; a compound of
Formula (Ia) wherein A is benzo, W is C(R4), R4 is chloro, X is
S, R1 is isopropyloxy, R2 is isopropyloxy, R3 is H, L is
CH2, and B is 2-trifluoromethyl-phenyl; a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is chloro, X is S, R1
is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
4-methylthio-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is 3-fluoro-phenyl, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is bromo, X is N(methylcarbonyl), R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 4-fluoro-3-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein
A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 2,3,5,6-tetrafluoro-4-hydroxy-phenyl; a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is chloro, X is S, R1
is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
2-fluoro-4-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is chloro, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is 4-chloro-phenyl;
a compound of Formula (Ia) wherein A is benzo, W is C(R4), R4
is bromo, X is S, R1 is isopropyloxy, R2 is isopropyloxy,
R3 is H, L is CH2, and B is 2-fluoro-5-trifluoromethyl-phenyl;
a compound of Formula (Ia) wherein A is benzo, W is C(R4), R4
is bromo, X is S, R1 is isopropyloxy, R2 is isopropyloxy,
R3 is H, L is CH2, and B is 4-trifluoromethyl-phenyl; a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
chloro, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is
CH2, and B is 3-fluoro-5-trifluoromethyl-phenyl; a compound of
Formula (Ia) wherein A is benzo, W is C(R4), R4 is chloro, X is
S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and
B is 2-chloro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is bromo, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is
2-chloro-5-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is H, X is S, R1 is isopropyloxy,
R2 is isopropyloxy, R3 is absent, L is ═CH-- taken to form
an alkene with the phosphorus-bearing adjacent atom, and B is
3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is
3-trifluoromethyl-4-fluoro-benzo, W is C(R4), R4 is bromo, X is
N(n-propyl), R1 is isopropyloxy, R2 is isopropyloxy, R3 is
H, L is CH2, and B is 4-fluoro-3-trifluoromethyl-phenyl; a compound
of Formula (Ia) wherein A is benzo, W is C(R4), R4 is bromo, X
is N(methyl), R1 is isopropyloxy, R2 is isopropyloxy, R3
is H, L is CH2, and B is 4-fluoro-3-trifluoromethyl-phenyl; a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
bromo, X is S, R1 is 2-acetoxy-ethoxy, R2 is 2-acetoxy-ethoxy,
R3 is H, L is CH2, and B is 3,4-difluoro-phenyl; a compound of
Formula (Ia) wherein A is benzo, W is C(R4), R4 is chloro, X is
S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and
B is 3-trifluoromethoxy-phenyl; a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is 4-fluoro-phenyl, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is bromo, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 3-amino-phenyl; a compound
of Formula (Ia) wherein A is benzo, W is C(R4), R4 is chloro, X
is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2,
and B is 4-methoxy-3-trifluoromethyl-phenyl; a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is chloro, X is S, R1
is isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2,
and B is 3,5-di-trifluoromethyl-phenyl; enantiomer B, a compound of
Formula (Ia) wherein A is benzo, W is C(R4), R4 is bromo, X is
S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and
B is 4-fluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is chloro, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is
2-chloro-3-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is chloro, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3,5-di-trifluoromethyl-phenyl; enantiomer B, a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W
is C(R4), R4 is chloro, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 2-trifluoromethyl-phenyl; a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
chloro, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is
CH2, and B is 2-chloro-5-trifluoromethyl-phenyl; enantiomer B, a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
bromo, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is
CH2, and B is 4-trifluoromethoxy-phenyl; a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is chloro, X is S, R1
is isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2,
and B is 2-chloro-5-trifluoromethyl-phenyl; a compound of Formula (Ia)
wherein A is 4-bromo-benzo, W is C(R4), R4 is bromo, X is S,
R1 is isopropyloxy, R2 is isopropyloxy, R3 is H, L is
CH2, and B is 2-fluoro-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is H, X is O, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is bromo, X is S, R1 is s-butyl, R2 is
s-butyl, R3 is H, L is CH2, and B is 3,4-difluoro-phenyl; and a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
3-aminocarbonyl-phenyl, X is S, R1 is ethoxy, R2 is ethoxy,
R3 is H, L is CH2, and B is 3,4-difluoro-phenyl.

40. A compound of Formula (Ia) ##STR00077## selected from the group
consisting of a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is methyl, X is S, R1 is isopropyloxy, R2
is isopropyloxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is i-propyl, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 3,4-difluoro-phenyl; a
compound of Formula (Ia) wherein A is 4-fluoro-benzo, W is C(R4),
R4 is methyl, X is S, R1 is ethoxy, R2 is ethoxy, R3
is H, L is CH2, and B is 3,4-difluoro-phenyl; a compound of Formula
(Ia) wherein A is benzo, W is C(R4), R4 is methyl, X is S,
R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B
is 3-chloro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is cyclopentyl, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 3,4-difluoro-phenyl; a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
methyl, X is S, R1 is ethoxy, R2 is isobutyl, R3 is H, L
is CH2, and B is 3,4-difluoro-phenyl; a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is methyl, X is S, R1
is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3-fluoro-phenyl; a compound of Formula (Ia) wherein A is 7-fluoro-benzo,
W is C(R4), R4 is methyl, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 3,4-difluoro-phenyl; a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
methyl, X is O, R1 is ethoxy, R2 is ethoxy, R3 is H, L is
CH2, and B is 3,4-difluoro-phenyl; a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is methyl, X is S, R1
is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
2,3-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is methyl, X is O, R1 is isopropyloxy, R2
is isopropyloxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is chloro, X is S, R1 is isopropyloxy, R2
is isopropyloxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is methyl, X is S, R1 is isobutyl, R2 is
isobutyl, R3 is H, L is OCH2, and B is 3,4-difluoro-phenyl; a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
methyl, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is
CH2, and B is 3,4-difluoro-phenyl; a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is
6-fluoro-benzo, W is C(R4), R4 is methyl, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is methyl, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 3,5-difluoro-phenyl; a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
methyl, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is
CH2, and B is 3-methyl-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is i-propyl, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W
is C(R4), R4 is cyclopropyl, X is S, R1 is isopropyloxy,
R2 is isopropyloxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is methyl, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 3,4-dichloro-phenyl; a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
methyl, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is
CH2, and B is 2-fluoro-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is methyl, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
2-fluoro-3-chloro-phenyl; a compound of Formula (Ia) wherein A is benzo,
W is C(R4), R4 is bromo, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 3,4-dichloro-phenyl; a
compound of Formula (Ia) wherein A is benzo, W is N, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W
is C(R4), R4 is methyl, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 2-methyl-phenyl; a compound
of Formula (Ia) wherein A is benzo, W is C(R4), R4 is methyl, X
is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2,
and B is 2-chloro-4-fluoro-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is methyl, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
2-chloro-3,5-difluoro-phenyl; a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is cyclopropyl, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is methyl, X is S, R1 is ethoxy, R2 is
methyl, R3 is H, L is CH2, and B is 3,4-difluoro-phenyl; a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
methyl, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is
CH2, and B is 3-trifluoromethyl-4-fluoro-phenyl; a compound of
Formula (Ia) wherein A is benzo, W is C(R4), R4 is methyl, X is
S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and
B is 3-methoxy-phenyl; a compound of Formula (Ia) wherein A is benzo, W
is C(R4), R4 is methyl, X is S, R1 is isobutyl, R2 is
isobutyl, R3 is H, L is CH2, and B is 3,4-difluoro-phenyl; a
compound of Formula (Ia) wherein A is (2,3-b)pyridin-2-yl, W is
C(R4), R4 is methyl, X is S, R1 is isopropyloxy, R2
is isopropyloxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is methyl, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 2,3-dichloro-phenyl; a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
methyl, X is S, R1 is ethoxy, R2 is isobutyl, R3 is H, L
is CH2, and B is 3,4-difluoro-phenyl; a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is methyl, X is S, R1
is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
2-fluoro-3-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is cyclopentyl, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W
is C(R4), R4 is H, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 3-trifluoromethyl-phenyl; a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
methyl, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is
CH2, and B is 3-bromo-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is cyclobutyl, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is methyl, X is S, R1 is n-propyl, R2 is
n-propyl, R3 is H, L is OCH2, and B is 3,4-difluoro-phenyl; a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
trifluoromethyl, X is S, R1 is isopropyloxy, R2 is
isopropyloxy, R3 is H, L is CH2, and B is 3,4-difluoro-phenyl;
a compound of Formula (Ia) wherein A is benzo, W is C(R4), R4
is methyl, X is S, R1 is n-propyl, R2 is n-propyl, R3 is
H, L is CH2, and B is 3,4-difluoro-phenyl; a compound of Formula
(Ia) wherein A is 5-fluoro-benzo, W is C(R4), R4 is methyl, X
is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2,
and B is 3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is methyl, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is naphthalen-2-yl;
a compound of Formula (Ia) wherein A is benzo, W is C(R4), R4
is methyl, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L
is CH2, and B is 2,5-dichloro-phenyl; a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is methyl, X is S, R1
is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
2-chloro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is methyl, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is
3-trifluoromethyl-4-chloro-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is methyl, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is 4-fluoro-phenyl;
a compound of Formula (Ia) wherein A is benzo, W is C(R4), R4
is H, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is
CH2, and B is 4-fluoro-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is methyl, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein A is benzo,
W is C(R4), R4 is methyl, X is S, R1 is
2,2-dimethyl-propyl, R2 is 2,2-dimethyl-propyl, R3 is H, L is
CH2, and B is 3,4-difluoro-phenyl; a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is methyl, X is S, R1
is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
2,6-dichloro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is methyl, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 4-trifluoromethoxy-phenyl;
a compound of Formula (Ia) wherein A is benzo, W is C(R4), R4
is methyl, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L
is CH2, and B is 3-fluoro-5-trifluoromethyl-phenyl; a compound of
Formula (Ia) wherein A is benzo, W is C(R4), R4 is methyl, X is
S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and
B is 3-trifluoromethoxy-phenyl; a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is H, X is S, R1 is ethoxy, R2
is ethoxy, R3 is H, L is CH2, and B is
3-fluoro-4-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is methyl, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
2-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein A is benzo,
W is C(R4), R4 is methyl, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is
2-fluoro-3-methyl-6-chloro-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is methyl, X is S, R5 is H,
R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B
is 2-trifluoromethoxy-phenyl; a compound of Formula (Ia) wherein A is
5-methyl-benzo, W is C(R4), R4 is methyl, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W
is C(R4), R4 is H, X is S, R1 is isopropyloxy, R2 is
isopropyloxy, R3 is H, L is CH2, and B is 3,4-difluoro-phenyl;
a compound of Formula (Ia) wherein A is benzo, W is C(R4), R4
is phenyl, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L
is CH2, and B is 3,4-dichloro-phenyl; a compound of Formula (Ia)
wherein A is 4-chloro-benzo, W is C(R4), R4 is methyl, X is S,
R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B
is 3,4-dichloro-phenyl; a compound of Formula (Ia) wherein A is benzo, W
is C(R4), R4 is methyl, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 2-bromo-phenyl; a compound
of Formula (Ia) wherein A is benzo, W is C(R4), R4 is methyl, X
is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2,
and B is 2-fluoro-5-trifluoromethyl-phenyl; a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is H, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
4-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein A is benzo,
W is C(R4), R4 is H, X is S, R1 is isopropyloxy, R2
is isopropyloxy, R3 is H, L is CH2, and B is
3-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein A is benzo,
W is C(R4), R4 is H, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 4-bromo-phenyl; a compound
of Formula (Ia) wherein A is benzo, W is C(R4), R4 is methyl, X
is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2,
and B is 5-chloro-benzo[1,3]dioxol-6-yl; a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is methyl, X is S, R1
is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3-(pyridin-4-yl)-phenyl; a compound of Formula (Ia) wherein A is benzo, W
is C(R4), R4 is methyl, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is
2-fluoro-3-chloro-5-trifluoromethyl-phenyl; a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is H, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is phenyl;
a compound of Formula (Ia) wherein A is benzo, W is C(R4), R4
is H, X is S, R5 is H, R1 is ethoxy, R2 is ethoxy, R3
is H, L is CH2, and B is 3,4-difluoro-phenyl; a compound of Formula
(Ia) wherein A is benzo, W is C(R4), R4 is methyl, X is S,
R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B
is 2,4-dichloro-5-fluoro-phenyl; a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is methyl, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is 3-biphenyl; a
compound of Formula (Ia) wherein A is benzo, W is C(R

4), R4 is H, X is S, R1 is ethoxy, R2 is ethoxy,
R3 is H, L is CH2, and B is 3,4-dichloro-phenyl; a compound of
Formula (Ia) wherein A is benzo, W is C(R4), R4 is methyl, X is
S, R1 is ethoxy, R2 is ethoxy, R3 is CH3, L is
CH2, and B is 3,4-difluoro-phenyl; a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is H, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
2-fluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is methyl, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is
2-chloro-3-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein A
is 6-methoxy-benzo, W is C(R4), R4 is methyl, X is S, R1
is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is H, X is S, R1 is ethoxy, R2 is ethoxy,
R3 is H, L is CH2, and B is naphthalen-2-yl; a compound of
Formula (Ia) wherein A is 4-trifluoromethyl-benzo, W is C(R4),
R4 is methyl, X is S, R1 is ethoxy, R2 is ethoxy, R3
is H, L is CH2, and B is 3,4-difluoro-phenyl; a compound of Formula
(Ia) wherein A is benzo, W is C(R4), R4 is H, X is S, R1
is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
2-chloro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is H, X is O, R1 is ethoxy, R2 is ethoxy,
R3 is H, L is CH2, and B is 4-fluoro-phenyl a compound of
Formula (Ia) wherein A is benzo, W is C(R4), R4 is bromo, X is
S, R1 is isopropyloxy, R2 is isopropyloxy, R3 is H, L is
CH2, and B is 3-methoxy-4-fluoro-phenyl; a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
2-hydroxy-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is bromo, X is S, R1 is isopropyloxy, R2 is
isopropyloxy, R3 is H, L is and B is
3-trifluoromethyl-4-fluoro-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3-hydroxy-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is bromo, X is S, R1 is isopropyloxy, R2 is
isopropyloxy, R3 is H, L is CH2, and B is
2-fluoro-3-hydroxy-phenyl; a compound of Formula (Ia) wherein A is benzo,
W is C(R4), R4 is bromo, X is S, R1 is isopropyloxy,
R2 is isopropyloxy, R3 is H, L is CH2, and B is
5-chloro-2-fluoro-phenyl; a compound of Formula (Ia) wherein A is benzo,
W is C(R4), R4 is bromo, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 3-methoxy-4-fluoro-phenyl;
a compound of Formula (Ia) wherein A is benzo, W is C(R4), R4
is bromo, X is S, R1 is isopropyloxy, R2 is isopropyloxy,
R3 is H, L is CH2, and B is 3-chloro-phenyl; a compound of
Formula (Ia) wherein A is benzo, W is C(R4), R4 is bromo, X is
S, R1 is isopropyloxy, R2 is isopropyloxy, R3 is H, L is
CH2, and B is 2,3,5,6-tetrafluoro-4-methoxy-phenyl; a compound of
Formula (Ia) wherein A is benzo, W is C(R4), R4 is bromo, X is
S, R1 is isopropyloxy, R2 is isopropyloxy, R3 is H, L is
CH2, and B is 2-fluoro-4-methoxy-phenyl; a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3-chloro-4-fluoro-phenyl; a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 4-trifluoromethylsulfonyl-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3-methoxy-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is bromo, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 4-chloro-phenyl; a compound
of Formula (Ia) wherein A is benzo, W is C(R4), R4 is bromo, X
is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2,
and B is 3-chloro-5-fluoro-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3,5-dimethoxy-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is bromo, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 5-chloro-2-fluoro-phenyl; a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
bromo, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is
CH2, and B is 3-hydroxy-4-fluoro-phenyl; a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3-chloro-4-fluoro-phenyl; a compound of Formula (Ia) wherein A is benzo,
W is C(R4), R4 is bromo, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 4-trifluoromethyl-phenyl; a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
bromo, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is
CH2, and B is 2-methoxy-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is chloro, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 4-trifluoromethylthio-phenyl; a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is chloro, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 4-trifluoromethylsulfonyl-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W
is C(R4), R4 is bromo, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 3-methoxy-phenyl; a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
bromo, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is
CH2, and B is 3-bromo-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is chloro, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 2-fluoro-4-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein
A is 4-fluoro-benzo, W is C(R4), R4 is bromo, X is S, R1
is isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2,
and B is 3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3-hydroxy-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is bromo, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 2-fluoro-3-methoxy-phenyl;
a compound of Formula (Ia) wherein A is benzo, W is C(R4), R4
is bromo, X is S, R1 is isopropyloxy, R2 is isopropyloxy,
R3 is H, L is CH2, and B is 3-fluoro-4-chloro-phenyl; a
compound of Formula (Ia) wherein A is 4-fluoro-benzo, W is C(R4),
R4 is bromo, X is S, R1 is isopropyloxy, R2 is
isopropyloxy, R3 is H, L is CH2, and B is
3-trifluoromethyl-4-fluoro-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is chloro, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3-chloro-4-fluoro-phenyl; a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 2-chloro-3-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein
A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3-fluoro-4-methoxy-phenyl; a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is 4-fluoro-phenyl;
a compound of Formula (Ia) wherein A is benzo, W is C(R4), R4
is bromo, X is S, R1 is isopropyloxy, R2 is isopropyloxy,
R3 is H, L is CH2, and B is 3-trifluoromethyl-4-fluoro-phenyl;
a compound of Formula (Ia) wherein A is benzo, W is C(R4), R4
is bromo, X is S, R1 is isopropyloxy, R2 is isopropyloxy,
R3 is H, L is CH2, and B is 3-fluoro-phenyl; a compound of
Formula (Ia) wherein A is benzo, W is C(R4), R4 is chloro, X is
S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and
B is 3-chloro-4-fluoro-phenyl; a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 2,3-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W
is C(R4), R4 is bromo, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 3-nitro-phenyl; a compound
of Formula (Ia) wherein A is benzo, W is C(R4), R4 is bromo, X
is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2,
and B is 3-pyrrol-1-yl-phenyl; a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
4-methoxy-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is bromo, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is
4-trifluoromethylthio-phenyl; a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
4-fluoro-3-trimethyl-phenyl; a compound of Formula (Ia) wherein A is
4-fluoro-benzo, W is C(R4), R4 is bromo, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is bromo, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 4-fluoro-phenyl; a compound
of Formula (Ia) wherein A is benzo, W is C(R4), R4 is bromo, X
is S, R1 is isopropyloxy, R2 is isopropyloxy, R3 is H, L
is CH2, and B is 4-methylthio-phenyl; a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3-fluoro-4-chloro-phenyl; a compound of Formula (Ia) wherein A is benzo,
W is C(R4), R4 is bromo, X is S, R1 is isopropyloxy,
R2 is isopropyloxy, R3 is H, L is CH2, and B is
4-fluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is bromo, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 4-trifluoromethoxy-phenyl;
a compound of Formula (Ia) wherein A is benzo, W is C(R4), R4
is bromo, X is S, R1 is isopropyloxy, R2 is isopropyloxy,
R3 is H, L is CH2, and B is 3-chloro-2-fluoro-phenyl; a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
bromo, X is S, R1 is isopropyloxy, R2 is isopropyloxy, R3
is H, L is CH2, and B is 3-trifluoromethylthio-phenyl; a compound of
Formula (Ia) wherein A is benzo, W is C(R4), R4 is bromo, X is
S, R1 is isopropyloxy, R2 is isopropyloxy, R3 is H, L is
CH2, and B is 2-fluoro-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is chloro, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 5-chloro-2-fluoro-phenyl; a compound of Formula (Ia) wherein A is
4-fluoro-benzo, W is C(R4), R4 is bromo, X is O, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is
(2,3-b)pyridin-2-yl, W is C(R4), R4 is bromo, X is S, R1
is isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2,
and B is 3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is O, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W
is C(R4), R4 is bromo, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 3-trifluoromethyl-phenyl; a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
bromo, X is O, R1 is ethoxy, R2 is ethoxy, R3 is H, L is
CH2, and B is 3,4-difluoro-phenyl; a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is chloro, X is S, R1
is isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2,
and B is 3-chloro-5-fluoro-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 2-fluoro-4-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein
A is 4-fluoro-benzo, W is C(R4), R4 is bromo, X is S, R1
is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3-trifluoromethyl-4-fluoro-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
4-difluoromethoxy-phenyl; a compound of Formula (Ia) wherein A is
4-fluoro-benzo, W is C(R4), R4 is methyl, X is O, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W
is C(R4), R4 is bromo, X is S, R1 is isopropyloxy, R2
is isopropyloxy, R3 is H, L is CH2, and B is
2-trifluoromethyl-4-fluoro-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is chloro, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3-trifluoromethoxy-phenyl; a compound of Formula (Ia) wherein A is
benzo, W is C(R

4), R4 is bromo, X is S, R1 is ethoxy, R2 is ethoxy,
R3 is H, L is CH2, and B is 2-fluoro-3-trifluoromethyl-phenyl;
a compound of Formula (Ia) wherein A is benzo, W is C(R4), R4
is bromo, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L
is CH2, and B is 3-trifluoromethyl-4-methoxy-phenyl; a compound of
Formula (Ia) wherein A is benzo, W is C(R4), R4 is bromo, X is
S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and
B is 3-fluoro-5-trifluoromethyl-phenyl; a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is chloro, X is S, R1
is isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2,
and B is 4-methylthio-phenyl; a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is chloro, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3-chloro-4-trifluoromethoxy-phenyl; a compound of Formula (Ia) wherein
A is benzo, W is C(R4), R4 is chloro, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3-trifluoromethylthio-phenyl; a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3-fluoro-4-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3,5-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W
is C(R4), R4 is bromo, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 3-fluoro-4-methoxy-phenyl;
a compound of Formula (Ia) wherein A is benzo, W is C(R4), R4
is bromo, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L
is CH2, and B is 3-chloro-4-trifluoromethoxy-phenyl; a compound of
Formula (Ia) wherein A is benzo, W is C(R4), R4 is bromo, X is
S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and
B is 2,3,5,6-tetrafluoro-4-methoxy-phenyl; a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
4-chloro-3-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 2-fluoro-3-chloro-5-trifluoromethyl-phenyl; a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is chloro, X is S, R1
is isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2,
and B is 4-trifluoromethoxy-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 2-fluoro-4-chloro-5-hydroxy-phenyl; a compound of Formula (Ia) wherein
A is benzo, W is C(R4), R4 is chloro, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3-trifluoromethyl-4-fluoro-phenyl; a compound of Formula (Ia) wherein
A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 4-chloro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is chloro, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 3-fluoro-4-chloro-phenyl; a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
bromo, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is
CH2, and B is 4-trifluoromethylsulfonyl-phenyl; a compound of
Formula (Ia) wherein A is benzo, W is C(R4), R4 is chloro, X is
S, R1 is isopropyloxy, R2 is isopropyloxy, R3 is H, L is
CH2, and B is 4-fluoro-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
2-fluoro-3-chloro-phenyl; a compound of Formula (Ia) wherein A is benzo,
W is C(R4), R4 is chloro, X is S, R1 is isopropyloxy,
R2 is isopropyloxy, R3 is H, L is CH2, and B is phenyl; a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
chloro, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is
CH2, and B is 5-chloro-2-fluoro-phenyl; a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
n-butyloxy, R2 is n-butyloxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is chloro, X is S, R1 is isopropyloxy, R2
is isopropyloxy, R3 is H, L is CH2, and B is
2-fluoro-3-chloro-phenyl; a compound of Formula (Ia) wherein A is benzo,
W is C(R4), R4 is chloro, X is S, R1 is isopropyloxy,
R2 is isopropyloxy, R3 is H, L is CH2, and B is
4-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein A is benzo,
W is C(R4), R4 is chloro, X is S, R1 is isopropyloxy,
R2 is isopropyloxy, R3 is H, L is CH2, and B is
3-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein A is benzo,
W is C(R4), R4 is bromo, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is
3,5-di-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is chloro, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3-bromo-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is chloro, X is S, R1 is isopropyloxy, R2
is isopropyloxy, R3 is H, L is CH2, and B is 3-chloro-phenyl; a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
chloro, X is S, R1 is isopropyloxy, R2 is isopropyloxy, R3
is H, L is CH2, and B is 2-fluoro-3-trifluoromethyl-phenyl; a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
bromo, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is
CH2, and B is 2-trifluoromethyl-phenyl; a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is chloro, X is S, R1
is isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2,
and B is 4-chloro-3-fluoro-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is chloro, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is 4-fluoro-phenyl;
a compound of Formula (Ia) wherein A is benzo, W is C(R4), R4
is chloro, X is S, R1 is isopropyloxy, R2 is isopropyloxy,
R3 is H, L is CH2, and B is 2-trifluoromethyl-4-fluoro-phenyl;
a compound of Formula (Ia) wherein A is benzo, W is C(R4), R4
is phenyl, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L
is CH2, and B is 3,4-difluoro-phenyl; a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
2-fluoro-4-chloro-5-methoxy-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3-methoxycarbonyl-phenyl; a compound of Formula (Ia) wherein A is benzo,
W is C(R4), R4 is 2-hydroxy-phenyl, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is chloro, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is
4-fluoro-3-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 4-methoxy-3-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein
A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 2-fluoro-4-chloro-5-methoxy-phenyl; a compound of Formula (Ia) wherein
A is benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is 3-cyano-phenyl;
a compound of Formula (Ia) wherein A is benzo, W is C(R4), R4
is chloro, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L
is CH2, and B is 4-trifluoromethylsulfonyl-phenyl; enantiomer B, a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
bromo, X is S, R1 is isopropyloxy, R2 is isopropyloxy, R3
is H, L is CH2, and B is 3-trifluoromethyl-4-fluoro-phenyl; a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
bromo, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is
CH2, and B is 4-cyano-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is chloro, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3-fluoro-4-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein
A is benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
2-fluoro-4-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is S, R1 is s-butyl,
R2 is s-butyl, R3 is H, L is OCH2, and B is
3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is bromo, X is S, R1 is 3-methyl-butoxy, R2
is 3-methyl-butoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is chloro, X is S, R1 is isopropyloxy, R2
is isopropyloxy, R3 is H, L is CH2, and B is
3-trifluoromethyl-4-chloro-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is chloro, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3-fluoro-5-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein
A is 4-fluoro-benzo, W is C(R4), R4 is bromo, X is O, R1
is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is bromo, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is
2-fluoro-5-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3-fluoro-4-chloro-phenyl; a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3-trimethylthio-phenyl; a compound of Formula (Ia) wherein A is benzo, W
is C(R4), R4 is thien-3-yl, X is S, R1 is ethoxy, R2
is ethoxy, R3 is H, L is CH2, and B is 3,4-difluoro-phenyl; a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
chloro, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is
CH2, and B is 3-bromo-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is chloro, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3-chloro-4-trifluoromethoxy-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is chloro, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 2-fluoro-5-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein
A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is absent, L is ═CH--
taken to form an alkene with the phosphorus-bearing adjacent atom, and B
is 3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W
is C(R4), R4 is chloro, X is S, R1 is isopropyloxy,
R2 is isopropyloxy, R3 is H, L is CH2, and B is
4-chloro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is chloro, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 3-chloro-2-fluoro-phenyl; a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
chloro, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is
CH2, and B is 3-chloro-5-fluoro-phenyl; a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is chloro, X is S, R1
is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3-chloro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is chloro, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is
3-fluoro-4-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is chloro, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
4-trifluoromethoxy-phenyl; a compound of Formula (Ia) wherein A is benzo,
W is C(R4), R4 is chloro, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is
4-fluoro-3-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is S, R1 is
methoxycarbonyl-methoxy, R2 is methoxycarbonyl-methoxy, R3 is
H, L is CH2, and B is 3,4-difluoro-phenyl; a compound of Formula
(Ia) wherein A is benzo, W is C(R4), R4 is bromo, X is S,
R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B
is 3-trifluoromethoxy-phenyl; a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
2-chloro-3-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
4-methylthio-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is chloro, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 3-fluoro-4-chloro-phenyl; a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
bromo, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is
CH2, and B is 2-fluoro-4-chloro-5-hydroxy-phenyl; enantiomer A, a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
bromo, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is
CH

2, and B is 4-trifluoromethoxy-phenyl; a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is chloro, X is S, R1
is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
4-chloro-3-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
2-trifluoromethyl-4-fluoro-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is 2-chloro-phenyl;
a compound of Formula (Ia) wherein A is benzo, W is C(R4), R4
is chloro, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L
is CH2, and B is 4-trifluoromethylthio-phenyl; a compound of Formula
(Ia) wherein A is benzo, W is C(R4), R4 is chloro, X is S,
R1 is isopropyloxy, R2 is isopropyloxy, R3 is H, L is
CH2, and B is 2-fluoro-4-trifluoromethyl-phenyl; a compound of
Formula (Ia) wherein A is benzo, W is C(R4), R4 is chloro, X is
S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and
B is 4-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is 2-fluoro-phenyl, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is chloro, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is
2-fluoro-5-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
2,3,5,6-tetrafluoro-4-hydroxy-phenyl; a compound of Formula (Ia) wherein
A is benzo, W is C(R4), R4 is chloro, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3-trifluoromethyl-4-methoxy-phenyl; a compound of Formula (Ia) wherein
A is benzo, W is C(R4), R4 is chloro, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 2,6-dichloro-phenyl; a compound of Formula (Ia) wherein A is benzo, W
is C(R4), R4 is chloro, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is
2-fluoro-3-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is S, R1 is methoxy,
R2 is methoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is
3-trifluoromethyl-4-fluoro-benzo, W is C(R4), R4 is bromo, X is
N(methanesulfonyl), R1 is isopropyloxy, R2 is isopropyloxy,
R3 is H, L is CH2, and B is 4-fluoro-3-trifluoromethyl-phenyl;
a compound of Formula (Ia) wherein A is benzo, W is C(R4), R4
is chloro, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L
is CH2, and B is 3-trifluoromethylthio-phenyl; a compound of Formula
(Ia) wherein A is benzo, W is C(R4), R4 is chloro, X is S,
R1 is isopropyloxy, R2 is isopropyloxy, R3 is H, L is
CH2, and B is 2-chloro-3-trifluoromethyl-phenyl; a compound of
Formula (Ia) wherein A is benzo, W is C(R4), R4 is chloro, X is
S, R1 is isopropyloxy, R2 is isopropyloxy, R3 is H, L is
CH2, and B is 2-trifluoromethyl-phenyl; a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is chloro, X is S, R1
is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
4-methylthio-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is 3-fluoro-phenyl, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is bromo, X is N(methylcarbonyl), R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 4-fluoro-3-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein
A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 2,3,5,6-tetrafluoro-4-hydroxy-phenyl; a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is chloro, X is S, R1
is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
2-fluoro-4-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is chloro, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is 4-chloro-phenyl;
a compound of Formula (Ia) wherein A is benzo, W is C(R4), R4
is bromo, X is S, R1 is isopropyloxy, R2 is isopropyloxy,
R3 is H, L is CH2, and B is 2-fluoro-5-trifluoromethyl-phenyl;
a compound of Formula (Ia) wherein A is benzo, W is C(R4), R4
is bromo, X is S, R1 is isopropyloxy, R2 is isopropyloxy,
R3 is H, L is CH2, and B is 4-trifluoromethyl-phenyl; and a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
chloro, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is
CH2, and B is 3-fluoro-5-trifluoromethyl-phenyl.

41. A compound of Formula (Ia) ##STR00078## selected from the group
consisting of a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is methyl, X is S, R1 is isopropyloxy, R2
is isopropyloxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is i-propyl, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 3,4-difluoro-phenyl; a
compound of Formula (Ia) wherein A is 4-fluoro-benzo, W is C(R4),
R4 is methyl, X is S, R1 is ethoxy, R2 is ethoxy, R3
is H, L is CH2, and B is 3,4-difluoro-phenyl; a compound of Formula
(Ia) wherein A is benzo, W is C(R4), R4 is methyl, X is S,
R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B
is 3-chloro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is cyclopentyl, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 3,4-difluoro-phenyl; a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
methyl, X is S, R1 is ethoxy, R2 is isobutyl, R3 is H, L
is CH2, and B is 3,4-difluoro-phenyl; a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is methyl, X is S, R1
is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3-fluoro-phenyl; a compound of Formula (Ia) wherein A is 7-fluoro-benzo,
W is C(R4), R4 is methyl, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 3,4-difluoro-phenyl; a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
methyl, X is O, R1 is ethoxy, R2 is ethoxy, R3 is H, L is
CH2, and B is 3,4-difluoro-phenyl; a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is methyl, X is S, R1
is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
2,3-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is methyl, X is O, R1 is isopropyloxy, R2
is isopropyloxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is chloro, X is S, R1 is isopropyloxy, R2
is isopropyloxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is methyl, X is S, R1 is isobutyl, R2 is
isobutyl, R3 is H, L is OCH2, and B is 3,4-difluoro-phenyl; a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
methyl, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is
CH2, and B is 3,4-difluoro-phenyl; a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is
6-fluoro-benzo, W is C(R4), R4 is methyl, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is methyl, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 3,5-difluoro-phenyl; a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
methyl, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is
CH2, and B is 3-methyl-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is i-propyl, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W
is C(R4), R4 is cyclopropyl, X is S, R1 is isopropyloxy,
R2 is isopropyloxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is methyl, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 3,4-dichloro-phenyl; a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
methyl, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is
CH2, and B is 2-fluoro-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is methyl, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
2-fluoro-3-chloro-phenyl; a compound of Formula (Ia) wherein A is benzo,
W is C(R4), R4 is bromo, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 3,4-dichloro-phenyl; a
compound of Formula (Ia) wherein A is benzo, W is N, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W
is C(R4), R4 is methyl, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 2-methyl-phenyl; a compound
of Formula (Ia) wherein A is benzo, W is C(R4), R4 is methyl, X
is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2,
and B is 2-chloro-4-fluoro-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is methyl, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
2-chloro-3,5-difluoro-phenyl; a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is cyclopropyl, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is methyl, X is S, R1 is ethoxy, R2 is
methyl, R3 is H, L is CH2, and B is 3,4-difluoro-phenyl; a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
methyl, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is
CH2, and B is 3-trifluoromethyl-4-fluoro-phenyl; a compound of
Formula (Ia) wherein A is benzo, W is C(R4), R4 is methyl, X is
S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and
B is 3-methoxy-phenyl; a compound of Formula (Ia) wherein A is benzo, W
is C(R4), R4 is methyl, X is S, R1 is isobutyl, R2 is
isobutyl, R3 is H, L is CH2, and B is 3,4-difluoro-phenyl; a
compound of Formula (Ia) wherein A is (2,3-b)pyridin-2-yl, W is
C(R4), R4 is methyl, X is S, R1 is isopropyloxy, R2
is isopropyloxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is methyl, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 2,3-dichloro-phenyl; a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
methyl, X is S, R1 is ethoxy, R2 is isobutyl, R3 is H, L
is CH2, and B is 3,4-difluoro-phenyl; a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is methyl, X is S, R1
is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
2-fluoro-3-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is cyclopentyl, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W
is C(R4), R4 is H, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 3-trifluoromethyl-phenyl; a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
methyl, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is
CH2, and B is 3-bromo-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is cyclobutyl, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is bromo, X is S, R1 is isopropyloxy, R2 is
isopropyloxy, R3 is H, L is CH2, and B is
3-methoxy-4-fluoro-phenyl; a compound of Formula (Ia) wherein A is benzo,
W is C(R4), R4 is bromo, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 2-hydroxy-phenyl; a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
bromo, X is S, R1 is isopropyloxy, R2 is isopropyloxy, R3
is H, L is and B is 3-trifluoromethyl-4-fluoro-phenyl; a compound of
Formula (Ia) wherein A is benzo, W is C(R4), R4 is bromo, X is
S, R1 is isopropyloxy, R2 is isopropyloxy, R3 is H, L is
CH2, and B is 3-hydroxy-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 2-fluoro-3-hydroxy-phenyl; a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 5-chloro-2-fluoro-phenyl; a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3-methoxy-4-fluoro-phenyl; a compound of Formula (Ia) wherein A is benzo,
W is C(R4), R4 is bromo, X is S, R1 is isopropyloxy,
R2 is isopropyloxy, R3 is H, L is CH2, and B is
3-chloro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is bromo, X is S, R1 is isopropyloxy, R2 is
isopropyloxy, R3 is H, L is CH2, and B is
2,3,5,6-tetrafluoro-4-methoxy-phenyl; a compound of Formula (Ia) wherein
A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 2-fluoro-4-methoxy-phenyl; a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3-chloro-4-fluoro-phenyl; a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 4-trifluoromethylsulfonyl-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3-methoxy-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is bromo, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 4-chloro-phenyl; a compound
of Formula (Ia) wherein A is benzo, W is C(R4), R4 is bromo, X
is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2,
and B is 3-chloro-5-fluoro-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3,5-dimethoxy-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is bromo, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 5-chloro-2-fluoro-phenyl; a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
bromo, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is
CH2, and B is 3-hydroxy-4-fluoro-phenyl; a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3-chloro-4-fluoro-phenyl; a compound of Formula (Ia) wherein A is benzo,
W is C(R4), R4 is bromo, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 4-trifluoromethyl-phenyl; a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
bromo, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is
CH2, and B is 2-methoxy-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is chloro, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 4-trifluoromethylthio-phenyl; a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is chloro, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 4-trifluoromethylsulfonyl-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W
is C(R4), R4 is bromo, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 3-methoxy-phenyl; a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
bromo, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is
CH2, and B is 3-bromo-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is chloro, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 2-fluoro-4-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein
A is 4-fluoro-benzo, W is C(R4), R4 is bromo, X is S, R1
is isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2,
and B is 3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3-hydroxy-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is bromo, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 2-fluoro-3-methoxy-phenyl;
a compound of Formula (Ia) wherein A is benzo, W is C(R4), R4
is bromo, X is S, R1 is isopropyloxy, R2 is isopropyloxy,
R3 is H, L is CH2, and B is 3-fluoro-4-chloro-phenyl; a
compound of Formula (Ia) wherein A is 4-fluoro-benzo, W is C(R4),
R4 is bromo, X is S, R1 is isopropyloxy, R2 is
isopropyloxy, R3 is H, L is CH2, and B is
3-trifluoromethyl-4-fluoro-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is chloro, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3-chloro-4-fluoro-phenyl; a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 2-chloro-3-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein
A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3-fluoro-4-methoxy-phenyl; a compound of Formula (Ia) wherein A is
benzo, W is C(R4

), R4 is bromo, X is S, R1 is ethoxy, R2 is ethoxy, R3
is H, L is CH2, and B is 4-fluoro-phenyl; a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3-trifluoromethyl-4-fluoro-phenyl; a compound of Formula (Ia) wherein
A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3-fluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is chloro, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 3-chloro-4-fluoro-phenyl; a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
bromo, X is S, R1 is isopropyloxy, R2 is isopropyloxy, R3
is H, L is CH2, and B is 2,3-difluoro-phenyl; a compound of Formula
(Ia) wherein A is benzo, W is C(R4), R4 is bromo, X is S,
R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B
is 3-nitro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is bromo, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 3-pyrrol-1-yl-phenyl; a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
bromo, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is
CH2, and B is 4-methoxy-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
4-trifluoromethylthio-phenyl; a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
4-fluoro-3-trimethyl-phenyl; a compound of Formula (Ia) wherein A is
4-fluoro-benzo, W is C(R4), R4 is bromo, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is bromo, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 4-fluoro-phenyl; a compound
of Formula (Ia) wherein A is benzo, W is C(R4), R4 is bromo, X
is S, R1 is isopropyloxy, R2 is isopropyloxy, R3 is H, L
is CH2, and B is 4-methylthio-phenyl; a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3-fluoro-4-chloro-phenyl; a compound of Formula (Ia) wherein A is benzo,
W is C(R4), R4 is bromo, X is S, R1 is isopropyloxy,
R2 is isopropyloxy, R3 is H, L is CH2, and B is
4-fluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is bromo, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 4-trifluoromethoxy-phenyl;
a compound of Formula (Ia) wherein A is benzo, W is C(R4), R4
is bromo, X is S, R1 is isopropyloxy, R2 is isopropyloxy,
R3 is H, L is CH2, and B is 3-chloro-2-fluoro-phenyl; a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
bromo, X is S, R1 is isopropyloxy, R2 is isopropyloxy, R3
is H, L is CH2, and B is 3-trifluoromethylthio-phenyl; a compound of
Formula (Ia) wherein A is benzo, W is C(R4), R4 is bromo, X is
S, R1 is isopropyloxy, R2 is isopropyloxy, R3 is H, L is
CH2, and B is 2-fluoro-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is chloro, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 5-chloro-2-fluoro-phenyl; a compound of Formula (Ia) wherein A is
4-fluoro-benzo, W is C(R4), R4 is bromo, X is O, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is
(2,3-b)pyridin-2-yl, W is C(R4), R4 is bromo, X is S, R1
is isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2,
and B is 3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is O, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W
is C(R4), R4 is bromo, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 3-trifluoromethyl-phenyl; a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
bromo, X is O, R1 is ethoxy, R2 is ethoxy, R3 is H, L is
CH2, and B is 3,4-difluoro-phenyl; a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is chloro, X is S, R1
is isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2,
and B is 3-chloro-5-fluoro-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 2-fluoro-4-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein
A is 4-fluoro-benzo, W is C(R4), R4 is bromo, X is S, R1
is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3-trifluoromethyl-4-fluoro-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
4-difluoromethoxy-phenyl; a compound of Formula (Ia) wherein A is
4-fluoro-benzo, W is C(R4), R4 is methyl, X is O, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W
is C(R4), R4 is bromo, X is S, R1 is isopropyloxy, R2
is isopropyloxy, R3 is H, L is CH2, and B is
2-trifluoromethyl-4-fluoro-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is chloro, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3-trifluoromethoxy-phenyl; a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
2-fluoro-3-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3-trifluoromethyl-4-methoxy-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3-fluoro-5-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is chloro, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 4-methylthio-phenyl; a compound of Formula (Ia) wherein A is benzo, W
is C(R4), R4 is chloro, X is S, R1 is isopropyloxy,
R2 is isopropyloxy, R3 is H, L is CH2, and B is
3-chloro-4-trifluoromethoxy-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is chloro, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3-trifluoromethylthio-phenyl; a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3-fluoro-4-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3,5-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W
is C(R4), R4 is bromo, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 3-fluoro-4-methoxy-phenyl;
a compound of Formula (Ia) wherein A is benzo, W is C(R4), R4
is bromo, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L
is CH2, and B is 3-chloro-4-trifluoromethoxy-phenyl; a compound of
Formula (Ia) wherein A is benzo, W is C(R4), R4 is bromo, X is
S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and
B is 2,3,5,6-tetrafluoro-4-methoxy-phenyl; a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
4-chloro-3-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 2-fluoro-3-chloro-5-trifluoromethyl-phenyl; a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is chloro, X is S, R1
is isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2,
and B is 4-trifluoromethoxy-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 2-fluoro-4-chloro-5-hydroxy-phenyl; a compound of Formula (Ia) wherein
A is benzo, W is C(R4), R4 is chloro, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3-trifluoromethyl-4-fluoro-phenyl; a compound of Formula (Ia) wherein
A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 4-chloro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is chloro, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 3-fluoro-4-chloro-phenyl; a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
bromo, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is
CH2, and B is 4-trifluoromethylsulfonyl-phenyl; a compound of
Formula (Ia) wherein A is benzo, W is C(R4), R4 is chloro, X is
S, R1 is isopropyloxy, R2 is isopropyloxy, R3 is H, L is
CH2, and B is 4-fluoro-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
2-fluoro-3-chloro-phenyl; a compound of Formula (Ia) wherein A is benzo,
W is C(R4), R4 is chloro, X is S, R1 is isopropyloxy,
R2 is isopropyloxy, R3 is H, L is CH2, and B is phenyl; a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
chloro, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is
CH2, and B is 5-chloro-2-fluoro-phenyl; a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
n-butyloxy, R2 is n-butyloxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is chloro, X is S, R1 is isopropyloxy, R2
is isopropyloxy, R3 is H, L is CH2, and B is
2-fluoro-3-chloro-phenyl; a compound of Formula (Ia) wherein A is benzo,
W is C(R4), R4 is chloro, X is S, R1 is isopropyloxy,
R2 is isopropyloxy, R3 is H, L is CH2, and B is
4-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein A is benzo,
W is C(R4), R4 is chloro, X is S, R1 is isopropyloxy,
R2 is isopropyloxy, R3 is H, L is CH2, and B is
3-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein A is benzo,
W is C(R4), R4 is bromo, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is
3,5-di-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is chloro, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3-bromo-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is chloro, X is S, R1 is isopropyloxy, R2
is isopropyloxy, R3 is H, L is CH2, and B is 3-chloro-phenyl; a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
chloro, X is S, R1 is isopropyloxy, R2 is isopropyloxy, R3
is H, L is CH2, and B is 2-fluoro-3-trifluoromethyl-phenyl; a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
bromo, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is
CH2, and B is 2-trifluoromethyl-phenyl; a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is chloro, X is S, R1
is isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2,
and B is 4-chloro-3-fluoro-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is chloro, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is 4-fluoro-phenyl;
a compound of Formula (Ia) wherein A is benzo, W is C(R4), R4
is chloro, X is S, R1 is isopropyloxy, R2 is isopropyloxy,
R3 is H, L is CH2, and B is 2-trifluoromethyl-4-fluoro-phenyl;
a compound of Formula (Ia) wherein A is benzo, W is C(R4), R4
is phenyl, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L
is CH2, and B is 3,4-difluoro-phenyl; a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
2-fluoro-4-chloro-5-methoxy-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3-methoxycarbonyl-phenyl; a compound of Formula (Ia) wherein A is benzo,
W is C(R4), R4 is 2-hydroxy-phenyl, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is chloro, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is
4-fluoro-3-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 4-methoxy-3-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein
A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 2-fluoro-4-chloro-5-methoxy-phenyl; a compound of Formula (Ia) wherein
A is benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is 3-cyano-phenyl;
a compound of Formula (Ia) wherein A is benzo, W is C(R4), R4
is chloro, X is S, R

1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
4-trifluoromethylsulfonyl-phenyl; enantiomer B, a compound of Formula
(Ia) wherein A is benzo, W is C(R4), R4 is bromo, X is S,
R1 is isopropyloxy, R2 is isopropyloxy, R3 is H, L is
CH2, and B is 3-trifluoromethyl-4-fluoro-phenyl; a compound of
Formula (Ia) wherein A is benzo, W is C(R4), R4 is bromo, X is
S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and
B is 4-cyano-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is chloro, X is S, R1 is isopropyloxy, R2
is isopropyloxy, R3 is H, L is CH2, and B is
3-fluoro-4-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
2-fluoro-4-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is S, R1 is s-butyl,
R2 is s-butyl, R3 is H, L is OCH2, and B is
3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is bromo, X is S, R1 is 3-methyl-butoxy, R2
is 3-methyl-butoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is chloro, X is S, R1 is isopropyloxy, R2
is isopropyloxy, R3 is H, L is CH2, and B is
3-trifluoromethyl-4-chloro-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is chloro, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3-fluoro-5-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein
A is 4-fluoro-benzo, W is C(R4), R4 is bromo, X is O, R1
is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is bromo, X is S, R1 is isopropyloxy, R2 is
isopropyloxy, R3 is H, L is CH2, and B is
2-fluoro-5-trifluoromethyl-phenyl; a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 4-trifluoromethyl-phenyl; and a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
2-fluoro-5-trifluoromethyl-phenyl.

42-67. (canceled)

Description:

CROSS-REFERENCE TO RELATED APPLICATIONS

[0001] This Application claims priority to U.S. Provisional Patent
Application No. 60/799,275, filed May 10, 2006, and U.S. Provisional
Patent Application No. 60/915,527, filed May 2, 2007, which is hereby
incorporated by reference in its entirety.

STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT

[0002] The research and development of the invention described below was
not federally sponsored.

BACKGROUND OF THE INVENTION

[0003] Transient receptor potential (TRP) channels are non-selective
cation channels that are activated by a variety of stimuli. Numerous
members of the ion channel family have been identified to date, including
the cold-menthol receptor-1, also called TRPM8 (McKemy D D et al. Nature
2002; 416(6876): 52-8). Collectively, the TRP channels and related
TRP-like receptors connote sensory responsivity to the entire continuum
of thermal exposure, selectively responding to threshold temperatures
ranging from noxious hot through noxious cold as well as to certain
chemicals that mimic these sensations. Specifically, TRPM8 is known to be
stimulated by cool to cold temperatures as well as by menthol and icilin,
which may be responsible for the therapeutic cooling sensation that these
agents evoke. TRPM8 is located on primary nociceptive neurons (A-delta
and C-fibers) and is modulated by inflammation-mediated second messenger
signals (Abe J et al. Neurosci Lett 2006, 397(1-2):140-4; Premkumar L S
et al. J Neurosci 2005; 25(49): 11322-9). The localization of TRPM8 on
both Aδ and C-fibers may provide a basis for abnormal cold
sensitivity in pathologic conditions wherein these neurons are altered,
resulting in pain, often of a burning nature (Kobayashi K et al. J Comp
Neurol 2005; 493(4): 596-606; Roza C et al. Pain 2006; 120(1-2): 24-35;
Xing H et al. J Neurophysiol 2006; 95(2): 1221-30). Cold intolerance and
paradoxical burning sensations induced by chemical or thermal cooling
closely parallel symptoms seen in a wide range of clinical disorders and
thus provide a strong rationale for the development of TRPM8 modulators
as novel antihyperalgesic or antiallodynic agents. TRPM8 is also known to
be expressed in the brain, lung, bladder, gastrointestinal tract, blood
vessels, prostate and immune cells, thereby providing the possibility for
therapeutic modulation in a wide range of maladies.

[0009] It is an object of the present invention to provide compounds that
are TRPM8 antagonists useful for treating TRPM8-mediated disorders. It is
another object of the invention to provide a process for preparing
compounds, compositions, intermediates and derivatives thereof. It is a
further object of the invention to provide methods for treating chronic
or acute pain, or the diseases that lead to such pain, and pulmonary or
vascular dysfunction. More particularly, the compounds of the present
invention are useful for the treatment of diseases or conditions
including, but not limited to, those that cause inflammatory or
neuropathic pain, cold intolerance or cold allodynia, peripheral vascular
pain, itch or urinary incontinence, chronic obstructive pulmonary
disease, pulmonary hypertension and anxiety or stress-related disorders.

SUMMARY OF THE INVENTION

[0010] The present invention is directed to compounds of Formula (I)

##STR00001##

wherein: [0011] A is benzo or pyrido; [0012] wherein benzo is optionally
substituted with a substituent selected from the group consisting of
C1-2alkyl, C1-2alkoxy, hydroxy, fluoro, chloro, bromo,
C1-2alkoxycarbonyl, aminocarbonyl, (C1-2alkyl)aminocarbonyl,
di(C1-2alkyl)aminocarbonyl, and trifluoromethyl; and benzo is
optionally further substituted with a substituent selected from the group
consisting of methyl, methoxy, hydroxy, fluoro, and chloro; [0013] and
wherein pyrido is optionally substituted with a substituent selected from
the group consisting of fluoro, chloro, bromo, and methyl; and pyrido is
optionally further substituted with fluoro; [0014] D is d-1 or d-2

[0014] ##STR00002## [0015] X is O, S, S(═O), S(O2), or
N--R6; wherein R6 is phenyl, C1-4alkyl, allyl,
C1-4alkylsulfonyl, C1-4alkylcarbonyl, or pyridinyl; [0016] W is
C(R4) or N; [0017] R4 is hydrogen; C1-8alkyl;
C1-8alkoxy; C1-6alkoxycarbonyl; chloro; bromo; cyano;
trifluoromethyl; phenyl; a heteroaryl selected from the group consisting
of furyl, thienyl, pyrrolyl, oxazolyl, thiazolyl, pyrazolyl, pyridinyl,
and pyrimidinyl; or a C3-6cycloalkyl; [0018] wherein phenyl is
optionally substituted with an aminocarbonyl, trifluoromethyl, or
trifluoromethoxy substituent; or phenyl is optionally substituted with
one to two substituents independently selected from the group consisting
of C1-2alkyl, C1-2alkoxy, fluoro, chloro, hydroxy, and cyano;
[0019] and wherein heteroaryl is optionally substituted with bromo or one
to two substituents independently selected from the group consisting of
methyl, fluoro, and chloro; [0020] R1 and R2 are independently
selected from the group consisting of C1-8alkyl; C1-8alkoxy;
--O(CH2)pO(CH2)qCH3;
--O(CH2)pO(CH2)qOCH3;
--O(CH2)rC(O)OCH3; --O(CH2)pOC(O)CH3;
--(CH2)pO(CH2)qCH3; phenyl(C1-3)alkyl;
phenyl(C1-3)alkoxy; and C3-8cycloalkyloxy; [0021] wherein p is
an integer from 2 to 6; and wherein q is an integer from 0 to 4, such
that the sum of p and q is less than or equal to six; wherein r is an
integer from 1 to 4; [0022] and, wherein the phenyl portion of
phenyl(C1-3)alkyl and phenyl(C1-3)alkoxy is optionally
substituted with one to two substituents independently selected from the
group consisting of C1-2alkyl, C1-2alkoxy, trifluoromethyl,
hydroxy, cyano, and halogen; [0023] and further, wherein C1-8alkyl
and C1-8alkoxy of R1 and R2 are optionally substituted
with hydroxy, difluoromethyl, trifluoromethyl, C3-6cycloalkyl,
carboxy, C1-2alkoxycarbonyl, di(C1-3alkyl)amino, aminocarbonyl,
(C1-3alkyl)aminocarbonyl, or di(C1-3alkyl)aminocarbonyl;
provided that when R1 is 2-(N,N-dimethylamino)-ethoxy, R2 is
other than 2-(N,N-dimethylamino)-ethoxy; [0024] R3 is hydrogen,
methyl, fluoro, chloro, bromo, or hydroxy; or R3 is absent when L is
alkene ═CH--; [0025] L is absent, --(CH2)n--,
--OC1-2alkyl-, or ═CH--; wherein n is 1 or 2; [0026] B is
hydrogen, phenyl, naphthyl, or a heteroaryl selected from the group
consisting of benzothiophenyl, benzo(1,3)dioxalyl, oxazolyl, thienyl,
furanyl, and benzofuranyl; [0027] wherein the phenyl of B is optionally
substituted with hydroxy, C1-3alkoxy, trifluoromethyl, nitro, amino,
phenyl or a heteroaryl selected from the group consisting of pyridinyl,
thienyl, furanyl, pyrrolyl, oxazolyl, and thiazolyl; and wherein phenyl
of B is optionally further substituted with a substituent selected from
the group consisting of methyl, fluoro, chloro, trifluoromethyl, methoxy,
and hydroxy; [0028] and wherein the naphthyl of B is optionally
substituted with 1 or 2 substituents selected from the group consisting
of hydrogen, methyl, fluoro, chloro, bromo, C1-3alkoxy, hydroxy, and
dimethylamino; [0029] or, the phenyl or heteroaryl substituent of B is
optionally substituted with a substituent independently selected from the
group consisting of C1-3alkyl, C1-3alkoxy, C1-3alkylthio,
fluoro, chloro, bromo, cyano, hydroxy, trifluoromethyl,
trifluoromethylthio, trifluoromethoxy, difluoromethoxy,
trifluoromethanesulfonyl, C1-2alkoxycarbonyl, aminocarbonyl,
(C1-2alkyl)aminocarbonyl, and di(C1-2alkyl)aminocarbonyl;
[0030] and the phenyl or heteroaryl substituent of B is optionally
further substituted with one to two fluoro or chloro substituents; [0031]
provided that when B is hydrogen and L is absent or --(CH2)n--,
then at least one of R1 and R2 is selected from the group
consisting of phenyl(C1-6)alkyl and phenyl(C1-6)alkoxy; [0032]
and enantiomers, diastereomers, racemates, and pharmaceutically
acceptable salts thereof; [0033] provided that a compound of Formula (I)
is other than [0034] a compound wherein A is 5-fluoro-benzo, D is d-2, W
is C(R4), R4 is methyl, X is S, R1 and R2 are each
isopropyloxy, R3 is hydrogen, L is CH2, and B is
3,4-difluorophenyl; [0035] a compound wherein A is
6-trifluoromethyl-benzo, D is d-2, W is C(R4), R4 is methyl, X
is S, R1 and R2 are each ethoxy, R3 is hydrogen, L is
CH2, and B is 3,4-difluorophenyl.; [0036] and further provided that
when D is d-2, R3 is hydrogen, and L is --(CH2)n--, then B
is optionally substituted with a substituent other than aminocarbonyl,
(C1-2alkyl)aminocarbonyl, or di(C1-2alkyl)aminocarbonyl.

[0037] Illustrative of the invention is a pharmaceutical composition
comprising a pharmaceutically acceptable carrier and a compound of
Formula (I). Also illustrative of the invention is a process for making a
pharmaceutical composition comprising mixing a compound of Formula (I)
and a pharmaceutically acceptable carrier.

[0038] The present invention is further directed to methods for treating
or ameliorating a TRPM8-mediated disorder. In particular, the method of
the present invention is directed to treating or ameliorating a TRPM8
receptor-mediated disorder including, but not limited to, inflammatory
pain, cold-intolerance or cold allodynia, peripheral vascular pain, itch
or urinary incontinence, chronic obstructive pulmonary disease, pulmonary
hypertension and anxiety or stress-related disorders.

[0039] The present invention is also directed to methods for producing the
instant compounds and pharmaceutical compositions and medicaments
thereof.

DETAILED DESCRIPTION OF THE INVENTION

[0040] As used herein, with reference to substituents, the term
"independently" means that when more than one of such substituent is
possible, such substituents may be the same or different from each other.

[0041] As used herein, unless otherwise noted, "alkyl" whether used alone
or as part of a substituent group refers to straight and branched carbon
chains having 1 to 8 carbon atoms or any number within this range.
Therefore, designated numbers of carbon atoms (e.g. C1-8) shall
refer independently to the number of carbon atoms in an alkyl moiety or
to the alkyl portion of a larger alkyl-containing substituent. In
substituent groups with multiple alkyl groups such as
(C1-6alkyl)2amino- the C1-6alkyl groups of the
dialkylamino may be the same or different.

[0042] As used herein, unless otherwise noted, the term "alkoxy" refers to
an --Oalkyl substituent group, wherein alkyl is as defined supra. To the
extent substituted, an alkyl and alkoxy chain may be substituted on a
carbon atom.

[0043] As used herein, the terms "alkenyl" and "alkynyl" refer to straight
and branched carbon chains having 2 or more carbon atoms, wherein an
alkenyl chain has at least one double bond in the chain and an alkynyl
chain has at least one triple bond in the chain.

[0044] The term "cycloalkyl" refers to saturated or partially unsaturated,
monocyclic or polycyclic hydrocarbon rings of from 3 to 14 carbon atom
members. Examples of such rings include, and are not limited to
cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl and
adamantyl. Similarly, "cycloalkenyl" refers to a cycloalkyl that contains
at least one double bond in the ring. Additionally, a "benzo-fused
cycloalkyl" is a cycloalkyl ring that is fused to a benzene ring. A
"heteroaryl-fused cycloalkyl" is a cycloalkyl ring that is fused to a 5
or 6 membered heteroaryl ring (containing one of O, S or N and,
optionally, one additional nitrogen).

[0045] The term "heterocyclyl" refers to a nonaromatic cyclic ring of 5 to
7 members in which 1 to 2 members are nitrogen, or a nonaromatic cyclic
ring of 5 to 7 members in which zero, one or two members are nitrogen and
up to two members are oxygen or sulfur; wherein, optionally, the ring
contains zero to one unsaturated bonds, and, optionally, when the ring is
of 6 or 7 members, it contains up to two unsaturated bonds. The term
"benzo-fused heterocyclyl" includes a 5 to 7 membered monocyclic
heterocyclic ring fused to a benzene ring. The term "heteroaryl-fused
heterocyclyl" refers to 5 to 7 membered monocyclic heterocyclic ring
fused to a 5 or 6 membered heteroaryl ring (containing one of O, S or N
and, optionally, one additional nitrogen). The term "cycloalkyl-fused
heterocyclyl" refers to a 5 to 7 membered monocyclic heterocyclic ring
fused to a 5 to 7 membered cycloalkyl or cycloalkenyl ring. Furthermore,
the term "heterocyclyl-fused heterocycyl" refers to a 5 to 7 membered
monocyclic heterocyclic ring fused to a 5 to 7 membered heterocyclyl ring
(of the same definition as above but absent the option of a further fused
ring). For instant compounds of the invention, the carbon atom ring
members that form the heterocyclyl ring are fully saturated. Other
compounds of the invention may have a partially saturated heterocyclyl
ring. The term "heterocyclyl" also includes a 5 to 7 membered monocyclic
heterocycle bridged to form bicyclic rings. Such compounds are not
considered to be fully aromatic and are not referred to as heteroaryl
compounds. Examples of heterocyclyl groups include, and are not limited
to, pyrrolinyl (including 2H-pyrrole, 2-pyrrolinyl or 3-pyrrolinyl),
pyrrolidinyl, 2-imidazolinyl, imidazolidinyl, 2-pyrazolinyl,
pyrazolidinyl, piperidinyl, morpholinyl, thiomorpholinyl and piperazinyl.

[0046] The term "aryl" refers to an unsaturated, aromatic monocyclic ring
of 6 carbon members or to an unsaturated, aromatic polycyclic ring of
from 10 to 14 carbon members. Examples of such aryl rings include, and
are not limited to, phenyl, naphthalenyl or anthracenyl. Preferred aryl
groups for the practice of this invention are phenyl and naphthalenyl.

[0047] The term "heteroaryl" refers to an aromatic ring of 5 or 6 members
wherein the ring consists of carbon atoms and has at least one heteroatom
member. Suitable heteroatoms include nitrogen, oxygen or sulfur. In the
case of 5 membered rings, the heteroaryl ring contains one member of
nitrogen, oxygen or sulfur and, in addition, may contain up to three
additional nitrogens. In the case of 6 membered rings, the heteroaryl
ring may contain from one to three nitrogen atoms. For the case wherein
the 6 membered ring has three nitrogens, at most two nitrogen atoms are
adjacent.

[0048] Optionally, the heteroaryl ring is fused to a benzene ring to form
a "benzo fused heteroaryl"; similarly, the heteroaryl ring is optionally
fused to a 5 or 6 membered heteroaryl ring (containing one of O, S or N
and, optionally, one additional nitrogen) to form a "heteroaryl-fused
heteroaryl"; similarly, the heteroaryl ring is optionally fused to a 5 to
7 membered cycloalkyl ring or a 5 to 7 membered heterocyclo ring (as
defined supra but absent the option of a further fused ring) to form a
"cycloalkyl-fused heteroaryl". Examples of heteroaryl groups include, and
are not limited to, furyl, thienyl, pyrrolyl, oxazolyl, thiazolyl,
imidazolyl, pyrazolyl, isoxazolyl, isothiazolyl, oxadiazolyl, triazolyl,
thiadiazolyl, pyridinyl, pyridazinyl, pyrimidinyl or pyrazinyl; examples
of heteroaryl groups with the optionally fused benzene rings include
indolyl, isoindolyl, indolinyl, benzofuryl, benzothienyl, indazolyl,
benzimidazolyl, benzthiazolyl, benzoxazolyl, benzisoxazolyl,
benzothiadiazolyl, benzotriazolyl, quinolizinyl, quinolinyl,
isoquinolinyl or quinazolinyl.

[0049] The term "arylalkyl" means an alkyl group substituted with an aryl
group (e.g., benzyl, phenethyl). Similarly, the term "arylalkoxy"
indicates an alkoxy group substituted with an aryl group (e.g.,
benzyloxy).

[0050] The term "halogen" refers to fluorine, chlorine, bromine and
iodine. Substituents that are substituted with multiple halogens are
substituted in a manner that provides compounds that are stable.

[0051] Whenever the term "alkyl" or "aryl" or either of their prefix roots
appear in a name of a substituent (e.g., arylalkyl, alkylamino) the name
is to be interpreted as including those limitations given above for
"alkyl" and "aryl." Designated numbers of carbon atoms (e.g., C1-6)
refer independently to the number of carbon atoms in an alkyl moiety, an
aryl moity, or in the alkyl portion of a larger substituent in which
alkyl appears as its prefix root. For alkyl and alkoxy substituents, the
designated number of carbon atoms includes all of the independent members
included within a given range specified. For example CO1-6 alkyl
would include methyl, ethyl, propyl, butyl, pentyl and hexyl individually
as well as sub-combinations thereof (e.g. C1-2, C1-3,
C1-4, C1-5, C2-6, C3-6, C4-6, C5-6,
C2-5, etc.).

[0052] As used herein, when L is "═CH--" in the compounds of Formula
(I), L represents an alkene between B and the carbon atom which is bound
to a phosphorus atom, taken to form d-1a or d-2a as illustrated below:

##STR00003##

[0053] In general, under standard nomenclature rules used throughout this
disclosure, the terminal portion of the designated side chain is
described first followed by the adjacent functionality toward the point
of attachment. Thus, for example, a "phenylC1-C6
alkylamidoC1-C6alkyl" substituent refers to a group of the
formula:

##STR00004##

[0054] Unless otherwise noted, substituents of ring A of the present
invention are named according to the numbering system shown below, in
which "X" is labeled position 1.

[0055] For example, when A is benzo, then the following numbering system
applies:

##STR00005##

[0056] Unless otherwise noted, it is intended that the definition of any
substituent or variable at a particular location in a molecule be
independent of its definitions elsewhere in that molecule. It is
understood that substituents and substitution patterns on the compounds
of this invention can be selected by one of ordinary skill in the art to
provide compounds that are chemically stable and that can be readily
synthesized by techniques known in the art as well as those methods set
forth herein.

[0057] The term "subject" as used herein, refers to an animal, preferably
a mammal, most preferably a human, who has been the object of treatment,
observation or experiment.

[0058] As used herein, the term "enantiomeric excess" refers to when one
enantiomer is present in greater quantity than the other enantiomer. Such
mixtures of two enantiomers, unlike a racemic mixture, will show a net
optical rotation. The specific rotation of the mixture may be determined
with knowledge of the specific rotation of the pure enantiomer, and
subsequently the enantiomeric excess (ee) can be determined using
equation (1)

ee=([α]obs/[α]max×100% (1).

[0059] One skilled in the art may determine specific amounts of each
enantiomer using HPLC on a chiral stationary phase. When the amounts of
each enantiomer are known, the enantiomeric excess may be determined
using equation (2):

ee=((R-S)/R+S))×100% (2)

wherein R and S are the respective fractions of enantiomers in a mixture
such that R+S=1.

[0060] The term "therapeutically effective amount" as used herein, means
that amount of active compound or pharmaceutical agent that elicits the
biological or medicinal response in a tissue system, animal or human that
is being sought by a researcher, veterinarian, medical doctor or other
clinician, which includes alleviation or partial alleviation of the
symptoms of the disease or disorder being treated.

[0061] As used herein, the term "composition" is intended to encompass a
product comprising the specified ingredients in the therapeutically
effective amounts, as well as any product which results, directly or
indirectly, from combinations of the specified ingredients in the
specified amounts.

[0062] For the purposes of the present invention, the term "antagonist" is
used to refer to a compound capable of producing, depending on the
circumstance, a functional antagonism of the TRPM8 ion channel, including
but not limited to competitive antagonists, non-competitive antagonists,
desensitizing agonists, and partial agonists.

[0063] For the purposes of the present invention, the term
inflammatory/hypersensitivity is used to refer to a condition that is
characterized by one or more hallmarks of inflammation, including but not
limited to edema, erythema, hyperthermia and pain, and/or by an
exaggerated physiologic or pathophysiologic response to one or more than
one type of stimulation, including but not limited to thermal, mechanical
and/or chemical stimulation.

[0064] An embodiment of the invention is a method of treating or
preventing migraine, post herpetic neuralgia, post traumatic neuralgia,
post chemotherapy neuralgia, complex regional pain syndrome I and II
(CRPS I/II), fibromyalgia, inflammatory bowel disease, pruritis, asthma,
chronic obstructive pulmonary disease, toothache, bone pain or pyresis in
a mammal, which method comprises administering to a mammal in need of
such treatment or prevention a therapeutically effective amount of a
TRPM8 antagonist.

[0065] Another embodiment of the invention is a method of treating or
preventing hypertension, peripheral vascular disease, Raynaud's disease,
reperfusion injury or frostbite in a mammal, which method comprises
administering to a mammal in need of such treatment or prevention a
therapeutically effective amount of a TRPM8 antagonist.

[0066] A further embodiment of the invention is a method of accelerating
post-anesthetic recovery or post hypothermia recovery in a mammal, which
method comprises administering to a mammal in need of such treatment a
therapeutically effective amount of a TRPM8 antagonist.

[0067] An embodiment of the present invention is directed to compounds of
Formula (I)

##STR00006##

wherein: [0068] A is benzo or pyrido; [0069] wherein benzo is optionally
substituted with a substituent selected from the group consisting of
hydrogen, C1-2alkyl, C1-2alkoxy, hydroxy, fluoro, chloro,
bromo, C1-2alkoxycarbonyl, aminocarbonyl,
(C1-2alkyl)aminocarbonyl, di(C1-2alkyl)aminocarbonyl, and
trifluoromethyl; and benzo is optionally further substituted with a
substituent selected from the group consisting of hydrogen, methyl,
methoxy, hydroxy, fluoro, chloro; [0070] and wherein pyrido is
optionally substituted with a substituent selected from the group
consisting of fluoro, chloro, bromo, and methyl; and pyrido is optionally
further substituted with fluoro; [0071] D is d-1 or d-2

[0071] ##STR00007## [0072] X is O, S, S(═O), S(O2), or
N--R6; wherein R6 is phenyl, C1-4alkyl, allyl,
C1-4-alkylsulfonyl, C1-4alkylcarbonyl, or pyridinyl; [0073] W
is C(R4) or N; [0074] R4 is hydrogen; C1-6alkyl;
C1-6alkoxy; C1-6alkoxycarbonyl; chloro; bromo; cyano;
trifluoromethyl; phenyl; a heteroaryl selected from the group consisting
of furyl, thienyl, pyrrolyl, oxazolyl, thiazolyl, pyrazolyl, pyridinyl,
and pyrimidinyl; or a C3-6cycloalkyl; [0075] wherein phenyl is
optionally substituted with a trifluoromethyl or trifluoromethoxy
substituent, or phenyl is optionally substituted with one to two
substituents independently selected from the group consisting of
hydrogen, C1-2alkyl, C1-2alkoxy, fluoro, chloro, hydroxy, and
cyano; [0076] and wherein heteroaryl is optionally substituted with bromo
or one to two substituents independently selected from the group
consisting of methyl, fluoro, and chloro; [0077] R1 and R2 are
independently selected from the group consisting of C1-8alkyl;
C1-8alkoxy; --O(CH2)pO(CH2)qCH3;
--(CH2)n--O--(CH2)qCH3; phenyl(C1-3)alkyl;
phenyl(C1-3)alkoxy; and C3-8cycloalkyloxy; [0078] wherein p is
an integer from 2 to 6; and wherein q is an integer from 0 to 4, such
that the sum of p and q is less than or equal to six; [0079] and, wherein
the phenyl portion of phenyl(C1-3)alkyl and phenyl(C1-3)alkoxy
is optionally substituted with one to two substituents independently
selected from the group consisting of C1-2alkyl, C1-2alkoxy,
trifluoromethyl, hydroxy, cyano, and halogen; [0080] and further, wherein
C1-8alkyl and C1-8alkoxy of R1 and R2 are optionally
substituted with hydroxy, difluoromethyl, trifluoromethyl,
C3-6cycloalkyl, carboxy, C1-2alkoxycarbonyl,
di(C1-3alkyl)amino, aminocarbonyl, (C1-3alkyl)aminocarbonyl, or
di(C1-3alkyl)aminocarbonyl; provided that when R1 is
2-(N,N-dimethylamino)-ethoxy, R2 is other than
2-(N,N-dimethylamino)-ethoxy; [0081] R3 is hydrogen, methyl, fluoro,
chloro, bromo, or hydroxy; [0082] L is absent, --(CH2)n--, or
--OC1-2alkyl-; wherein n is 1 or 2; [0083] B is hydrogen, phenyl,
naphthyl, or a heteroaryl selected from the group consisting of
benzothiophenyl, benzo(1,3)dioxalyl, oxazolyl, thienyl, furanyl, and
benzofuranyl; wherein the phenyl of B is optionally substituted with
phenyl or a heteroaryl selected from the group consisting of pyridinyl,
thienyl, furanyl, oxazolyl, and thiazolyl; and wherein phenyl is
optionally further substituted with a substituent selected from the group
consisting of methyl, fluoro, chloro, trifluoromethyl, methoxy, and
hydroxy; and [0084] wherein the naphthyl of B is optionally substituted
with 1 or 2 substituents selected from the group consisting of hydrogen,
methyl, fluoro, chloro, bromo, methoxy, hydroxyl, and dimethylamino;
[0085] or, a B substituent other than hydrogen is optionally substituted
with a substituent independently selected from the group consisting of
C1-3alkyl, C1-3alkoxy, fluoro, chloro, bromo, cyano, hydroxy,
trifluoromethyl, trifluoromethylthio, trifluoromethoxy, methanesulfonyl,
trifluoromethanesulfonyl, C1-2alkoxycarbonyl, aminocarbonyl,
(C1-2alkyl)aminocarbonyl, and di(C1-2alkyl)aminocarbonyl; and B
is optionally further substituted with one to two fluoro or chloro
substituents; [0086] provided that when B is hydrogen and L is absent or
--(CH2)n--, then at least one of R1 and R2 is
selected from the group consisting of phenyl(C1-6)alkyl and
phenyl(C1-6)alkoxy; [0087] and enantiomers, diastereomers,
racemates, and pharmaceutically acceptable salts thereof; [0088] provided
that a compound of Formula (I) is other than [0089] a compound wherein A
is 5-fluoro-benzo, D is d-2, W is C(R4), R4 is methyl, X is S,
R1 and R2 are each isopropyloxy, R3 is hydrogen, L is
CH2, and B is 3,4-difluorophenyl; or [0090] a compound wherein A is
6-trifluoromethyl-benzo, D is d-2, W is C(R4), R4 is methyl, X
is S, R1 and R2 are each ethoxy, R3 is hydrogen, L is
CH2, and B is 3,4-difluorophenyl; [0091] and further provided that
when D is d-2, R3 is hydrogen, and L is --(CH2)n--, then B
is optionally substituted with a substituent other than aminocarbonyl,
(C1-2alkyl)aminocarbonyl, or di(C1-2alkyl)aminocarbonyl.

[0092] Embodiments of the present invention include a compound of Formula
(I) wherein: [0093] a) A is benzo optionally substituted with
trifluoromethyl, C1-2alkyl, or C1-2alkoxy, and optionally
further substituted with a substituent selected from the group consisting
of methyl, methoxy, fluoro, and chloro; [0094] b) A is benzo optionally
substituted with trifluoromethyl, C1-2alkyl, C1-2alkoxy,
fluoro, or chloro; [0095] c) A is benzo optionally substituted with
C1-2alkyl, fluoro, or chloro; [0096] d) D is d-2

[0096] ##STR00008## [0097] e) X is O, S, S(O2), or N--R6;
wherein R6 is phenyl; [0098] f) X is O, S, or S(O2); [0099] g)
X is O or S; [0100] h) W is C(R4); [0101] i) R4 is hydrogen,
C1-6alkyl, chloro, bromo, trifluoromethyl, phenyl, pyridinyl
optionally substituted with fluoro, or C3-6cycloalkyl; [0102] j)
R4 is hydrogen, methyl, isopropyl, 2,2-dimethyl-propyl, chloro,
bromo, trifluoromethyl, phenyl, pyridinyl optionally substituted with
fluoro, or C3-6cycloalkyl; [0103] k) R4 is hydrogen, methyl,
isopropyl, chloro, bromo, trifluoromethyl, pyridinyl optionally
substituted with fluoro, cyclopropyl, cyclobutyl, or cyclopentyl; [0104]
l) R4 is methyl, isopropyl, chloro, bromo, trifluoromethyl,
pyridinyl optionally substituted with fluoro, cyclopropyl, cyclobutyl, or
cyclopentyl; [0105] m) R1 and R2 are independently selected
from the group consisting of C1-4alkyl optionally substituted with
di(C1-3alkyl)amino, C1-4alkoxy optionally substituted with
di(C1-3alkyl)amino, --O(CH2)pO(CH2)qCH3,
phenyl(C1-3)alkyl, phenyl(C1-3)alkoxy, and
C3-6cycloalkyloxy; wherein p is an integer from 2 to 4 and q is 0;
[0106] wherein the phenyl portion of phenyl(C1-3)alkyl and
phenyl(C1-3)alkoxy is optionally substituted with one to two
substituents independently selected from the group consisting of methyl,
methoxy, fluoro, chloro, and bromo; provided that when R1 is
2-(N,N-dimethylamino)-ethoxy, R2 is other than
2-(N,N-dimethylamino)-ethoxy; [0107] further provided that only one of
R1 and R2 is phenyl(C1-3)alkyl or phenyl(C1-3)alkoxy;
[0108] n) R1 and R2 are independently selected from the group
consisting of C1-4alkyl, phenyl(C1-3)alkyl, and
C1-4alkoxy; wherein the phenyl portion of phenyl(C1-3)alkyl is
optionally substituted with methoxy; [0109] o) R1 and R2 are
independently selected from the group consisting of methyl, isobutyl,
ethoxy, and isopropyloxy; [0110] p) R3 is hydrogen, methyl, fluoro,
or bromo; [0111] q) R3 is hydrogen or methyl; [0112] r) R3 is
hydrogen; [0113] s) L is absent, --(CH2)n--, or --OCH2--;
and n is 1 or 2; [0114] t) L is --(CH2)n-- or --OCH2--;
and n is 1; [0115] u) L is --(CH2)n--; and n is 1; [0116] v) B
is phenyl, naphthyl, or a heteroaryl selected from the group consisting
of benzothiophenyl and benzo(1,3)dioxalyl; [0117] wherein the phenyl of B
is optionally substituted with phenyl or pyridinyl; and the phenyl of B
is optionally further substituted with a substituent independently
selected from the group consisting of methyl, fluoro, and chloro; [0118]
or, B is optionally substituted with a substituent selected from the
group consisting of C1-3alkyl, C1-3alkoxy, fluoro, chloro,
bromo, cyano, hydroxy, trifluoromethyl, trifluoromethoxy,
C1-2alkoxycarbonyl, aminocarbonyl, (C1-2alkyl)aminocarbonyl,
and di(C1-2alkyl)aminocarbonyl; and B is optionally further
substituted with a chloro or fluoro substituent; [0119] provided that
when R3 is hydrogen, and L is --(CH2)n-- wherein n is 1 or
2, B is optionally substituted with a substituent other than
aminocarbonyl, (C1-3alkyl)aminocarbonyl, or
di(C1-3alkyl)aminocarbonyl; [0120] w) B is phenyl, naphthyl, or
benzo(1,3)dioxalyl; wherein the phenyl of B is optionally substituted
with phenyl or pyridinyl; [0121] or, B is optionally substituted with a
substituent selected from the group consisting of C1-3alkyl, fluoro,
chloro, bromo, trifluoromethyl, and trifluoromethoxy; and B is optionally
further substituted with a chloro or fluoro substituent; [0122] x) B is
phenyl optionally substituted with phenyl or pyridinyl; or, B is phenyl
optionally substituted with a substituent independently selected from the
group consisting of C1-3alkyl, fluoro, chloro, bromo,
trifluoromethyl, and trifluoromethoxy; and B is optionally further
substituted with a chloro or fluoro substituent; [0123] y) B is phenyl
substituted with a substituent selected from the group consisting of
C1-3alkyl, fluoro, chloro, bromo, trifluoromethyl, and
trifluoromethoxy; and B is optionally further substituted with a chloro
or fluoro substituent; and [0124] z) B is phenyl substituted with a
substituent selected from the group consisting of fluoro, chloro, and
trifluoromethyl; and B is optionally further substituted with a chloro or
fluoro substituent; [0125] and any combination of embodiments a) through
z) above, provided that it is understood that combinations in which
different embodiments of the same substituent would be combined are
excluded.

[0126] Another embodiment of the present invention includes a compound of
Formula (I)

##STR00009##

wherein: [0127] A is benzo or pyrido; [0128] wherein benzo is optionally
substituted with a substituent selected from the group consisting of
C1-2alkyl, C1-2alkoxy, hydroxy, fluoro, chloro, bromo,
C1-2alkoxycarbonyl, aminocarbonyl, (C1-2alkyl)aminocarbonyl,
di(C1-2alkyl)aminocarbonyl, and trifluoromethyl; and benzo is
optionally further substituted with a substituent selected from the group
consisting of methyl, methoxy, hydroxy, fluoro, and chloro; [0129] and
wherein pyrido is optionally substituted with a substituent selected from
the group consisting of fluoro, chloro, bromo, and methyl; and pyrido is
optionally further substituted with fluoro; [0130] D is d-1 or d-2

[0130] ##STR00010## [0131] X is O, S, S(═O), S(O2), or
N--R6; wherein R6 is phenyl, C1-4alkyl, allyl,
C1-4alkylsulfonyl, C1-4alkylcarbonyl, or pyridinyl; provided
that X is other than N--R6 when W is N; [0132] W is C(R4) or N;
[0133] R4 is hydrogen; C1-6alkyl; C1-6alkoxy;
C1-6alkoxycarbonyl; chloro; bromo; cyano; trifluoromethyl; phenyl; a
heteroaryl selected from the group consisting of furyl, thienyl,
pyrrolyl, oxazolyl, thiazolyl, pyrazolyl, pyridinyl, and pyrimidinyl; or
a C3-6cycloalkyl; [0134] wherein phenyl is optionally substituted
with an aminocarbonyl, trifluoromethyl, or trifluoromethoxy substituent;
or phenyl is optionally substituted with one to two substituents
independently selected from the group consisting of C1-2alkyl,
C1-2alkoxy, fluoro, chloro, hydroxy, and cyano; [0135] and wherein
heteroaryl is optionally substituted with bromo or one to two
substituents independently selected from the group consisting of methyl,
fluoro, and chloro; [0136] R1 and R2 are independently selected
from the group consisting of C1-8alkyl; C1-8alkoxy;
--O(CH2)pO(CH2)qCH3;
--O(CH2)pO(CH2)qOCH3;
--O(CH2)rC(O)OCH3; --O(CH2)pOC(O)CH3;
--(CH2)pO(CH2)qOCH3; phenyl(C1-3)alkyl;
phenyl(C1-3)alkoxy; and C3-8cycloalkyloxy; [0137] wherein p is
an integer from 2 to 6; and wherein q is an integer from 0 to 4, such
that the sum of p and q is less than or equal to six; wherein r is an
integer from 1 to 4; [0138] and, wherein the phenyl portion of
phenyl(C1-3)alkyl and phenyl(C1-3)alkoxy is optionally
substituted with one to two substituents independently selected from the
group consisting of C1-2alkyl, C1-2alkoxy, trifluoromethyl,
hydroxy, cyano, and halogen; [0139] and further, wherein C1-8alkyl
and C1-8alkoxy of R1 and R2 are optionally substituted
with hydroxy, difluoromethyl, trifluoromethyl, C3-6cycloalkyl,
carboxy, C1-2alkoxycarbonyl, di(C1-3alkyl)amino, aminocarbonyl,
(C1-3alkyl)aminocarbonyl, or di(C1-3alkyl)aminocarbonyl;
provided that when R1 is 2-(N,N-dimethylamino)-ethoxy, R2 is
other than 2-(N,N-dimethylamino)-ethoxy; [0140] R3 is hydrogen,
methyl, fluoro, chloro, bromo, or hydroxy; or R3 is absent when L is
alkene ═CH--; [0141] L is absent, --(CH2)p--,
--OC1-2alkyl-, or ═CH--; wherein n is 1 or 2; [0142] B is
hydrogen, phenyl, naphthyl, or a heteroaryl selected from the group
consisting of benzothiophenyl, benzo(1,3)dioxalyl, oxazolyl, thienyl,
furanyl, and benzofuranyl; [0143] wherein the phenyl of B is optionally
substituted with hydroxy, C1-3alkoxy, trifluoromethyl, nitro, amino,
phenyl or a heteroaryl selected from the group consisting of pyridinyl,
thienyl, furanyl, pyrrolyl, oxazolyl, and thiazolyl; and [0144] wherein
phenyl of B is optionally further substituted with a substituent selected
from the group consisting of methyl, fluoro, chloro, trifluoromethyl,
methoxy, and hydroxy; [0145] and wherein the naphthyl of B is optionally
substituted with 1 or 2 substituents selected from the group consisting
of hydrogen, methyl, fluoro, chloro, bromo, C1-3alkoxy, hydroxy, and
dimethylamino; [0146] or, the phenyl or heteroaryl substituent of B is
optionally substituted with a substituent independently selected from the
group consisting of C1-3alkyl, C1-3alkoxy, C1-3alkylthio,
fluoro, chloro, bromo, cyano, hydroxy, trifluoromethyl,
trifluoromethylthio, trifluoromethoxy, difluoromethoxy,
trifluoromethanesulfonyl, C1-2alkoxycarbonyl, aminocarbonyl,
(C1-2alkyl)aminocarbonyl, and di(C1-2alkyl)aminocarbonyl;
[0147] and the phenyl or heteroaryl substituent of B is optionally
further substituted with one to two fluoro or chloro substituents; [0148]
provided that when B is hydrogen and L is absent or --(CH2)n--,
then at least one of R1 and R2 is selected from the group
consisting of phenyl(C1-6)alkyl and phenyl(C1-6)alkoxy; [0149]
and enantiomers, diastereomers, racemates, and pharmaceutically
acceptable salts thereof; [0150] provided that a compound of Formula (I)
is other than [0151] a compound wherein A is 5-fluoro-benzo, D is d-2, W
is C(R4), R4 is methyl, X is S, R1 and R2 are each
isopropyloxy, R3 is hydrogen, L is CH2, and B is
3,4-difluorophenyl; [0152] a compound wherein A is
6-trifluoromethyl-benzo, D is d-2, W is C(R4), R4 is methyl, X
is S, R1 and R2 are each ethoxy, R3 is hydrogen, L is
CH2, and B is 3,4-difluorophenyl.; and further provided that when D
is d-2, R3 is hydrogen, and L is --(CH2)n--, then B is
optionally substituted with a substituent other than aminocarbonyl,
(C1-2alkyl)aminocarbonyl, or di(C1-2alkyl)aminocarbonyl.

[0153] Further embodiments of the present invention include a compound of
Formula (I) wherein: [0154] a) A is unsubstituted pyrido or benzo
optionally substituted with trifluoromethyl, C1-2alkyl, fluoro,
chloro, bromo, or C1-2alkoxy, and optionally further substituted
with a substituent selected from the group consisting of methyl, methoxy,
fluoro, and chloro; [0155] b) A is benzo optionally substituted with
trifluoromethyl, C1-2alkyl, C1-2alkoxy, fluoro, chloro, or
bromo; [0156] c) A is benzo optionally substituted with C1-2alkyl,
fluoro, or chloro; [0157] d) D is d-2

[0157] ##STR00011## [0158] e) X is O, S, S(O2), or N--R6;
wherein R6 is phenyl; provided that X is other than N--R6 when
W is N; [0159] f) X is O, S, or S(O2); [0160] g) X is O or S; [0161]
h) W is C(R4); [0162] i) R4 is hydrogen; C1-6alkyl;
chloro; bromo; trifluoromethyl; phenyl optionally substituted with
hydroxy, aminocarbonyl, or fluoro; pyridinyl optionally substituted with
fluoro; thienyl; or C3-6cycloalkyl; [0163] j) R4 is hydrogen;
methyl; isopropyl; 2,2-dimethyl-propyl; chloro; bromo; trifluoromethyl;
phenyl optionally substituted with hydroxy, aminocarbonyl, or fluoro;
pyridinyl optionally substituted with fluoro; thienyl; or
C3-6cycloalkyl; [0164] k) R4 is hydrogen; methyl; isopropyl;
chloro; bromo; trifluoromethyl; phenyl optionally substituted with
hydroxy or fluoro; pyridinyl optionally substituted with fluoro; thienyl;
cyclopropyl; cyclobutyl; or cyclopentyl; [0165] l) R4 is methyl;
isopropyl; chloro; bromo; trifluoromethyl; pyridinyl optionally
substituted with fluoro; thienyl; cyclopropyl; cyclobutyl; or
cyclopentyl; [0166] m) R1 and R2 are independently selected
from the group consisting of C1-4alkyl optionally substituted with
di(C1-3alkyl)amino; C1-5alkoxy optionally substituted with
di(C1-3alkyl)amino; --O(CH2)pO(CH2)qCH3;
--O(CH2)rC(O)OCH3; --O(CH2)pOC(O)CH3;
phenyl(C1-3)alkyl; phenyl(C1-3)alkoxy; and
C3-6cycloalkyloxy; wherein p is an integer from 2 to 4, q is 0, and
r is 1; wherein the phenyl portion of phenyl(C1-3)alkyl and
phenyl(C1-3)alkoxy is optionally substituted with one to two
substituents independently selected from the group consisting of methyl,
methoxy, fluoro, chloro, and bromo; provided that when R1 is
2-(N,N-dimethylamino)-ethoxy, R2 is other than
2-(N,N-dimethylamino)-ethoxy; further provided that only one of R1
and R2 is phenyl(C1-3)alkyl or phenyl(C1-3)alkoxy; [0167]
n) R1 and R2 are independently selected from the group
consisting of C1-4alkyl, phenyl(C1-3)alkyl,
--OCH2C(O)OCH3, --O(CH2)2OC(O)CH3, and
C1-4alkoxy; wherein the phenyl portion of phenyl(C1-3)alkyl is
optionally substituted with methoxy; [0168] o) R1 and R2 are
independently selected from the group consisting of methyl, isobutyl,
ethoxy, and isopropyloxy; [0169] p) R3 is hydrogen, methyl, fluoro,
or bromo; or R3 is absent when L is ═CH--; [0170] q) R3 is
hydrogen or methyl; or R3 is absent when L is ═CH--; [0171] r)
R3 is hydrogen; [0172] s) L is absent, --(CH2)n--,
--OCH2--, or ═CH--; and n is 1 or 2; [0173] t) L is
--(CH2)n--, --OCH2--, or ═CH--; and n is 1; [0174] u)
L is --(CH2)n--; and n is 1; [0175] v) B is phenyl, naphthyl,
or a heteroaryl selected from the group consisting of benzothiophenyl and
benzo(1,3)dioxalyl; [0176] wherein the phenyl of B is optionally
substituted with phenyl or pyridinyl; and the phenyl of B is optionally
further substituted with a substituent independently selected from the
group consisting of methyl, fluoro, or chloro; [0177] or, the phenyl or
heteroaryl of B is optionally substituted with a substituent selected
from the group consisting of C1-3alkyl, C1-3alkoxy, fluoro,
chloro, bromo, cyano, hydroxy, trifluoromethyl, trifluoromethoxy,
C1-2alkoxycarbonyl, aminocarbonyl, (C1-2alkyl)aminocarbonyl,
and di(C1-2alkyl)aminocarbonyl; and B is optionally further
substituted with a chloro or fluoro substituent; [0178] provided that
when R3 is hydrogen, and L is --(CH2)n-- wherein n is 1 or
2, B is optionally substituted with a substituent other than
aminocarbonyl, (C1-3alkyl)aminocarbonyl, or
di(C1-3alkyl)aminocarbonyl; [0179] w) B is phenyl, naphthyl, or
benzo(1,3)dioxalyl; wherein the phenyl of B is optionally substituted
with phenyl or pyridinyl; [0180] or, B other than naphthyl is optionally
substituted with a substituent selected from the group consisting of
C1-3alkyl, fluoro, chloro, bromo, trifluoromethyl, and
trifluoromethoxy; and B is optionally further substituted with a chloro
or fluoro substituent; [0181] x) B is phenyl optionally substituted with
phenyl or pyridinyl; [0182] or, B is phenyl optionally substituted with a
substituent independently selected from the group consisting of
C1-3alkyl, fluoro, chloro, bromo, trifluoromethyl, and
trifluoromethoxy; and B is optionally further substituted with a chloro
or fluoro substituent; [0183] y) B is phenyl substituted with a
substituent selected from the group consisting of C1-3alkyl, fluoro,
chloro, bromo, trifluoromethyl, and trifluoromethoxy; and B is optionally
further substituted with a chloro or fluoro substituent; and [0184] z) B
is phenyl substituted with a substituent selected from the group
consisting of fluoro, chloro, and trifluoromethyl; and B is optionally
further substituted with a chloro or fluoro substituent; and any
combination of embodiments a) through z) above, provided that it is
understood that combinations in which different embodiments of the same
substituent would be combined are excluded.

[0185] A further embodiment of the present invention is directed to a
compound of Formula (I) wherein: [0186] A is unsubstituted pyrido or
benzo optionally substituted with trifluoromethyl, C1-2alkyl,
fluoro, chloro, bromo, or C1-2alkoxy, and optionally further
substituted with a substituent selected from the group consisting of
methyl, methoxy, fluoro, and chloro; [0187] D is d-1 or d-2

[0187] ##STR00012## [0188] X is O, S, S(O2), or N--R6;
wherein R6 is phenyl; provided that X is other than N--R6 when
W is N; [0189] W is C(R4) or N; [0190] R4 is hydrogen;
C1-6alkyl; chloro; bromo; trifluoromethyl; phenyl optionally
substituted with hydroxy, aminocarbonyl, or fluoro; pyridinyl optionally
substituted with fluoro; thienyl; or C3-6cycloalkyl; [0191] R1
and R2 are independently selected from the group consisting of
C1-4alkyl optionally substituted with di(C1-3alkyl)amino;
C1-5alkoxy optionally substituted with di(C1-3alkyl)amino;
--O(CH2)pO(CH2)qCH3;
--O(CH2)rC(O)OCH3, --O(CH2)pOC(O)CH3,
phenyl(C1-3)alkyl; phenyl(C1-3)alkoxy; and
C3-6cycloalkyloxy; [0192] wherein p is an integer from 2 to 4, q is
0, and r is 1; [0193] wherein the phenyl portion of
phenyl(C1-3)alkyl and phenyl(C1-3)alkoxy is optionally
substituted with one to two substituents independently selected from the
group consisting of methyl, methoxy, fluoro, chloro, and bromo; [0194]
provided that when R1 is 2-(N,N-dimethylamino)-ethoxy, R2 is
other than 2-(N,N-dimethylamino)-ethoxy; [0195] further provided that
only one of R1 and R2 is phenyl(C1-3)alkyl or
phenyl(C1-3)alkoxy; [0196] R3 is hydrogen, methyl, fluoro, or
bromo; or R3 is absent when L is ═CH--; [0197] L is absent,
--(CH2)n--, --OCH2--, or ═CH--; and n is 1 or 2;
[0198] B is phenyl, naphthyl, or a heteroaryl selected from the group
consisting of benzothiophenyl and benzo(1,3)dioxalyl; [0199] wherein the
phenyl of B is optionally substituted with phenyl or pyridinyl; and the
phenyl of B is optionally further substituted with a substituent
independently selected from the group consisting of methyl, fluoro, or
chloro; [0200] or, the phenyl or heteroaryl of B is optionally
substituted with a substituent selected from the group consisting of
C1-3alkyl, C1-3alkoxy, fluoro, chloro, bromo, cyano, hydroxy,
trifluoromethyl, trifluoromethoxy, C1-2alkoxycarbonyl,
aminocarbonyl, (C1-2alkyl)aminocarbonyl, and
di(C1-2alkyl)aminocarbonyl; and B is optionally further substituted
with a chloro or fluoro substituent; [0201] provided that when R3 is
hydrogen, and L is --(CH2)n-- wherein n is 1 or 2, B is
optionally substituted with a substituent other than aminocarbonyl,
(C1-3alkyl)aminocarbonyl, or di(C1-3alkyl)aminocarbonyl; [0202]
provided that a compound of Formula (I) is other than [0203] a compound
wherein A is 5-fluoro-benzo, D is d-2, W is C(R4), R4 is
methyl, X is S, R1 and R2 are each isopropyloxy, R3 is
hydrogen, L is CH2, and B is 3,4-difluorophenyl; or [0204] a
compound wherein A is 6-trifluoromethyl-benzo, D is d-2, W is C(R4),
R4 is methyl, X is S, R1 and R2 are each ethoxy, R3
is hydrogen, L is CH2, and B is 3,4-difluorophenyl; [0205] and
further provided that when D is d-2, R3 is hydrogen, and L is
--(CH2)n--, then B is optionally substituted with a substituent
other than aminocarbonyl, (C1-3alkyl)aminocarbonyl, or
di(C1-3alkyl)aminocarbonyl.

[0206] A further embodiment of the present invention is directed to a
compound of Formula (I) wherein: [0207] A is unsubstituted pyrido or
benzo optionally substituted with trifluoromethyl, C1-2alkyl,
fluoro, chloro, bromo, or C1-2alkoxy, and optionally further
substituted with a substituent selected from the group consisting of
methyl, methoxy, fluoro, and chloro; [0208] D is d-1 or d-2

[0208] ##STR00013## [0209] X is O, S, S(O2), or N--R6;
wherein R6 is phenyl; provided that X is other than N--R6 when
W is N; [0210] W is C(R4) or N; [0211] R4 is hydrogen;
C1-6alkyl; chloro; bromo; trifluoromethyl; phenyl optionally
substituted with hydroxy, aminocarbonyl, or fluoro; pyridinyl optionally
substituted with fluoro; thienyl; or C3-6cycloalkyl; [0212] R1
and R2 are independently selected from the group consisting of
C1-4alkyl optionally substituted with di(C1-3alkyl)amino;
C1-5alkoxy optionally substituted with di(C1-3alkyl)amino;
--O(CH2)pO(CH2)qCH3;
--O(CH2)rC(O)OCH3; --O(CH2)pOC(O)CH3;
phenyl(C1-3)alkyl; phenyl(C1-3)alkoxy; and
C3-6cycloalkyloxy; wherein p is an integer from 2 to 4, q is 0, and
r is 1; [0213] wherein the phenyl portion of phenyl(C1-3)alkyl and
phenyl(C1-3)alkoxy is optionally substituted with one to two
substituents independently selected from the group consisting of methyl,
methoxy, fluoro, chloro, and bromo; [0214] provided that when R1 is
2-(N,N-dimethylamino)-ethoxy, R2 is other than
2-(N,N-dimethylamino)-ethoxy; [0215] further provided that only one of
R1 and R2 is phenyl(C1-3)alkyl or phenyl(C1-3)alkoxy;
[0216] R3 is hydrogen, methyl, fluoro, or bromo; [0217] L is absent,
--(CH2)p--, or --OCH2--; and n is 1 or 2; [0218] B is
phenyl, naphthyl, or a heteroaryl selected from the group consisting of
benzothiophenyl and benzo(1,3)dioxalyl; [0219] wherein the phenyl of B is
optionally substituted with phenyl or pyridinyl; and the phenyl of B is
optionally further substituted with a substituent independently selected
from the group consisting of methyl, fluoro, or chloro; [0220] or, the
phenyl or heteroaryl of B is optionally substituted with a substituent
selected from the group consisting of C1-3alkyl, C1-3alkoxy,
fluoro, chloro, bromo, cyano, hydroxy, trifluoromethyl, trifluoromethoxy,
C1-2alkoxycarbonyl, aminocarbonyl, (C1-2alkyl)aminocarbonyl,
and di(C1-2alkyl)aminocarbonyl; and B is optionally further
substituted with a chloro or fluoro substituent; [0221] provided that
when R3 is hydrogen, and L is --(CH2)n-- wherein n is 1 or
2, B is optionally substituted with a substituent other than
aminocarbonyl, (C1-3alkyl)aminocarbonyl, or
di(C1-3alkyl)aminocarbonyl; provided that a compound of Formula (I)
is other than [0222] a compound wherein A is 5-fluoro-benzo, D is d-2, W
is C(R4), R4 is methyl, X is S, R1 and R2 are each
isopropyloxy, R3 is hydrogen, L is CH2, and B is
3,4-difluorophenyl; or [0223] a compound wherein A is
6-trifluoromethyl-benzo, D is d-2, W is C(R4), R4 is methyl, X
is S, R1 and R2 are each ethoxy, R3 is hydrogen, L is
CH2, and B is 3,4-difluorophenyl; [0224] and further provided that
when D is d-2, R3 is hydrogen, and L is --(CH2)n--, then B
is optionally substituted with a substituent other than aminocarbonyl,
(C1-3alkyl)aminocarbonyl, or di(C1-3alkyl)aminocarbonyl.

[0225] A further embodiment of the present invention is directed to a
compound of Formula (I) wherein: [0226] A is benzo optionally substituted
with trifluoromethyl, C1-2alkyl, C1-2alkoxy, fluoro, chloro, or
bromo; [0227] D is d-1 or d-2

[0227] ##STR00014## [0228] X is O, S, or S(O2); [0229] W is
C(R4); [0230] R4 is hydrogen; methyl; isopropyl;
2,2-dimethyl-propyl; chloro; bromo; trifluoromethyl; phenyl optionally
substituted with hydroxy, aminocarbonyl, or fluoro; pyridinyl optionally
substituted with fluoro; thienyl; or C3-6cycloalkyl; [0231] R1
and R2 are independently selected from the group consisting of
C1-4alkyl, phenyl(C1-3)alkyl, --OCH2C(O)OCH3,
--O(CH2)2OC(O)CH3, and C1-4alkoxy; wherein the phenyl
portion of phenyl(C1-3)alkyl is optionally substituted with methoxy;
[0232] R3 is hydrogen or methyl; or R3 is absent when L is
═CH--; [0233] L is --(CH2)n--, --OCH2--, or ═CH--;
and n is 1; [0234] B is phenyl, naphthyl, or benzo(1,3)dioxalyl; wherein
the phenyl of B is optionally substituted with phenyl or pyridinyl;
[0235] or, B other than naphthyl is optionally substituted with a
substituent selected from the group consisting of C1-3alkyl, fluoro,
chloro, bromo, trifluoromethyl, and trifluoromethoxy; and B is optionally
further substituted with a chloro or fluoro substituent; [0236] and
enantiomers, diastereomers, racemates, and pharmaceutically acceptable
salts thereof; [0237] provided that a compound of Formula (I) is other
than [0238] a compound wherein A is 5-fluoro-benzo, D is d-2, W is
C(R4), R4 is methyl, X is S, R1 and R2 are each
isopropyloxy, R3 is hydrogen, L is CH2, and B is
3,4-difluorophenyl; or [0239] a compound wherein A is
6-trifluoromethyl-benzo, D is d-2, W is C(R4), R4 is methyl, X
is S, R1 and R2 are each ethoxy, R3 is hydrogen, L is
CH2, and B is 3,4-difluorophenyl; [0240] and further provided that
when D is d-2, R3 is hydrogen, and L is --(CH2)n--, then B
is optionally substituted with a substituent other than aminocarbonyl,
(C1-3alkyl)aminocarbonyl, or di(C1-3alkyl)aminocarbonyl.

[0241] Further embodiments of the present invention are directed to a
compound of Formula (I) wherein: [0242] A is benzo optionally substituted
with C1-2alkyl, fluoro, or chloro; [0243] D is d-2

[0243] ##STR00015## [0244] X is O or S; [0245] W is C(R4); [0246]
R4 is hydrogen; methyl; isopropyl; chloro; bromo; trifluoromethyl;
phenyl optionally substituted with hydroxy or fluoro; pyridinyl
optionally substituted with fluoro; thienyl; cyclopropyl; cyclobutyl; or
cyclopentyl; [0247] R1 and R2 are independently selected from
the group consisting of methyl, isobutyl, ethoxy, and isopropyloxy;
[0248] R3 is hydrogen; [0249] L is --(CH2)n--; and n is 1;
[0250] B is phenyl optionally substituted with phenyl or pyridinyl;
[0251] or, B is phenyl optionally substituted with a substituent
independently selected from the group consisting of C1-3alkyl,
fluoro, chloro, bromo, trifluoromethyl, and trifluoromethoxy; and B is
optionally further substituted with a chloro or fluoro substituent;
[0252] and enantiomers, diastereomers, racemates, and pharmaceutically
acceptable salts thereof; [0253] provided that a compound of Formula (I)
is other than a compound wherein A is 5-fluoro-benzo, D is d-2, W is
C(R4), R4 is methyl, X is S, R1 and R2 are each
isopropyloxy, R3 is hydrogen, L is CH2, and B is
3,4-difluorophenyl.

[0254] Further embodiments of the present invention are directed to a
compound of Formula (I) wherein: [0255] A is benzo optionally substituted
with C1-2alkyl, fluoro, or chloro; [0256] D is d-2

[0256] ##STR00016## [0257] X is O or S; [0258] W is C(R4); [0259]
R4 is methyl; isopropyl; chloro; bromo; trifluoromethyl; phenyl
optionally substituted with hydroxy or fluoro; pyridinyl optionally
substituted with fluoro; thienyl; cyclopropyl; cyclobutyl; or
cyclopentyl; [0260] R1 and R2 are independently selected from
the group consisting of methyl, isobutyl, ethoxy, and isopropyloxy;
[0261] R3 is hydrogen; [0262] L is --(CH2)n--; and n is 1;
[0263] B is phenyl substituted with a substituent selected from the group
consisting of C1-3alkyl, fluoro, chloro, bromo, trifluoromethyl, and
trifluoromethoxy; and B is optionally further substituted with a chloro
or fluoro substituent; [0264] and enantiomers, diastereomers, racemates,
and pharmaceutically acceptable salts thereof; [0265] provided that a
compound of Formula (I) is other than [0266] a compound wherein A is
5-fluoro-benzo, D is d-2, W is C(R4), R4 is methyl, X is S,
R1 and R2 are each isopropyloxy, R3 is hydrogen, L is
CH2, and B is 3,4-difluorophenyl.

[0267] Further embodiments of the present invention are directed to a
compound of Formula (I) wherein: [0268] A is benzo optionally substituted
with C1-2alkyl, fluoro, or chloro; [0269] D is d-2

[0269] ##STR00017## [0270] X is O or S; [0271] W is C(R4); [0272]
R4 is methyl; isopropyl; chloro; bromo; trifluoromethyl; pyridinyl;
cyclopropyl; cyclobutyl; or cyclopentyl; wherein pyridinyl is optionally
substituted with fluoro; [0273] R1 and R2 are independently
selected from the group consisting of methyl, isobutyl, ethoxy, and
isopropyloxy; [0274] R3 is hydrogen; [0275] L is
--(CH2)n--; and n is 1; [0276] B is phenyl substituted with a
substituent selected from the group consisting of fluoro, chloro, and
trifluoromethyl; and B is optionally further substituted with a chloro or
fluoro substituent; [0277] and enantiomers, diastereomers, racemates, and
pharmaceutically acceptable salts thereof; [0278] provided that a
compound of Formula (I) is other than [0279] a compound wherein A is
5-fluoro-benzo, D is d-2, W is C(R4), R4 is methyl, X is S,
R1 and R2 are each isopropyloxy, R3 is hydrogen, L is
CH2, and B is 3,4-difluorophenyl.

[0280] A further embodiment of the present invention is directed to a
compound Formula (Ia)

##STR00018##

selected from the group consisting of [0281] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is methyl, X is S, R1
is isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2,
and B is 3,4-difluoro-phenyl; [0282] a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is i-propyl, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; [0283] a compound of Formula (Ia) wherein A is
4-fluoro-benzo, W is C(R4), R4 is methyl, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; [0284] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is methyl, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is 3-chloro-phenyl;
[0285] a compound of Formula (Ia) wherein A is benzo, W is C(R4),
R4 is cyclopentyl, X is S, R1 is ethoxy, R2 is ethoxy,
R3 is H, L is CH2, and B is 3,4-difluoro-phenyl; [0286] a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
methyl, X is S, R1 is ethoxy, R2 is isobutyl, R3 is H, L
is CH2, and B is 3,4-difluoro-phenyl; [0287] a compound of Formula
(Ia) wherein A is benzo, W is C(R4), R4 is methyl, X is S,
R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B
is 3-fluoro-phenyl; [0288] a compound of Formula (Ia) wherein A is
7-fluoro-benzo, W is C(R4), R4 is methyl, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; [0289] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is methyl, X is O, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; [0290] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is methyl, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
2,3-difluoro-phenyl; [0291] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is methyl, X is O, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3,4-difluoro-phenyl; [0292] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is chloro, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3,4-difluoro-phenyl; [0293] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is methyl, X is S, R1 is isobutyl,
R2 is isobutyl, R3 is H, L is OCH2, and B is
3,4-difluoro-phenyl; [0294] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is methyl, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; [0295] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3,4-difluoro-phenyl; [0296] a compound of Formula (Ia) wherein A is
6-fluoro-benzo, W is C(R4), R4 is methyl, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; [0297] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is methyl, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3,5-difluoro-phenyl; [0298] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is methyl, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is 3-methyl-phenyl;
[0299] a compound of Formula (Ia) wherein A is benzo, W is C(R4),
R4 is i-propyl, X is S, R1 is isopropyloxy, R2 is
isopropyloxy, R3 is H, L is CH2, and B is 3,4-difluoro-phenyl;
[0300] a compound of Formula (Ia) wherein A is benzo, W is C(R4),
R4 is cyclopropyl, X is S, R1 is isopropyloxy, R2 is
isopropyloxy, R3 is H, L is CH2, and B is 3,4-difluoro-phenyl;
[0301] a compound of Formula (Ia) wherein A is benzo, W is C(R4),
R4 is methyl, X is S, R1 is ethoxy, R2 is ethoxy, R3
is H, L is CH2, and B is 3,4-dichloro-phenyl; [0302] a compound of
Formula (Ia) wherein A is benzo, W is C(R4), R4 is methyl, X is
S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and
B is 2-fluoro-phenyl; [0303] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is methyl, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
2-fluoro-3-chloro-phenyl; [0304] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-dichloro-phenyl; [0305] a compound of Formula (Ia) wherein A is
benzo, W is N, X is S, R1 is isopropyloxy, R2 is isopropyloxy,
R3 is H, L is CH2, and B is 3,4-difluoro-phenyl; [0306] a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
methyl, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is
CH2, and B is 2-methyl-phenyl; [0307] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is methyl, X is S, R1
is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
2-chloro-4-fluoro-phenyl; [0308] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is methyl, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
2-chloro-3,5-difluoro-phenyl; [0309] a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is cyclopropyl, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; [0310] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is methyl, X is S, R1 is ethoxy,
R2 is methyl, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; [0311] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is methyl, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3-trifluoromethyl-4-fluoro-phenyl; [0312] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is methyl, X is S, R1
is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3-methoxy-phenyl; [0313] a compound of Formula (Ia) wherein A is benzo, W
is C(R4), R4 is methyl, X is S, R1 is isobutyl, R2 is
isobutyl, R3 is H, L is CH2, and B is 3,4-difluoro-phenyl;
[0314] a compound of Formula (Ia) wherein A is (2,3-b)pyridin-2-yl, W is
C(R4), R4 is methyl, X is S, R1 is isopropyloxy, R2
is isopropyloxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; [0315] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is methyl, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
2,3-dichloro-phenyl; [0316] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is methyl, X is S, R1 is ethoxy,
R2 is isobutyl, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; [0317] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is methyl, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
2-fluoro-3-trifluoromethyl-phenyl; [0318] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is cyclopentyl, X is S,
R1 is isopropyloxy, R2 is isopropyloxy, R3 is H, L is
CH2, and B is 3,4-difluoro-phenyl; [0319] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is H, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3-trifluoromethyl-phenyl; [0320] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is methyl, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is 3-bromo-phenyl;
[0321] a compound of Formula (Ia) wherein A is benzo, W is C(R4),
R4 is cyclobutyl, X is S, R1 is ethoxy, R2 is ethoxy,
R3 is H, L is CH2, and B is 3,4-difluoro-phenyl; [0322] a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
methyl, X is S, R1 is n-propyl, R2 is n-propyl, R3 is H, L
is OCH2, and B is 3,4-difluoro-phenyl; [0323] a compound of Formula
(Ia) wherein A is benzo, W is C(R4), R4 is trifluoromethyl, X
is S, R1 is isopropyloxy, R2 is isopropyloxy, R3 is H, L
is CH2, and B is 3,4-difluoro-phenyl; [0324] a compound of Formula
(Ia) wherein A is benzo, W is C(R4), R4 is methyl, X is S,
R1 is n-propyl, R2 is n-propyl, R3 is H, L is CH2,
and B is 3,4-difluoro-phenyl; [0325] a compound of Formula (Ia) wherein A
is 5-fluoro-benzo, W is C(R4), R4 is methyl, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; [0326] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is methyl, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is naphthalen-2-yl;
[0327] a compound of Formula (Ia) wherein A is benzo, W is C(R4),
R4 is methyl, X is S, R1 is ethoxy, R2 is ethoxy, R3
is H, L is CH2, and B is 2,5-dichloro-phenyl; [0328] a compound of
Formula (Ia) wherein A is benzo, W is C(R4), R4 is methyl, X is
S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and
B is 2-chloro-phenyl; [0329] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is methyl, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3-trifluoromethyl-4-chloro-phenyl; [0330] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is methyl, X is S, R1
is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
4-fluoro-phenyl; [0331] a compound of Formula (Ia) wherein A is benzo, W
is C(R4), R4 is H, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 4-fluoro-phenyl; [0332] a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
methyl, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is
CH2, and B is 3-trifluoromethyl-phenyl; [0333] a compound of Formula
(Ia) wherein A is benzo, W is C(R4), R4 is methyl, X is S,
R1 is 2,2-dimethyl-propyl, R2 is 2,2-dimethyl-propyl, R3
is H, L is CH2, and B is 3,4-difluoro-phenyl; [0334] a compound of
Formula (Ia) wherein A is benzo, W is C(R4), R4 is methyl, X is
S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and
B is 2,6-dichloro-phenyl; [0335] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is methyl, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
4-trifluoromethoxy-phenyl; [0336] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is methyl, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3-fluoro-5-trifluoromethyl-phenyl; [0337] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is methyl, X is S, R1
is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3-trifluoromethoxy-phenyl; [0338] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is H, X is S, R1 is ethoxy, R2
is ethoxy, R3 is H, L is CH2, and B is
3-fluoro-4-trifluoromethyl-phenyl; [0339] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is methyl, X is S, R1
is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
2-trifluoromethyl-phenyl; [0340] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is methyl, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
2-fluoro-3-methyl-6-chloro-phenyl; [0341] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is methyl, X is S, R1
is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
2-trifluoromethoxy-phenyl; [0342] a compound of Formula (Ia) wherein A is
5-methyl-benzo, W is C(R4), R4 is methyl, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3,4-difluoro-phenyl; [0343] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is H, X is S, R1 is isopropyloxy,
R2 is isopropyloxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; [0344] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is phenyl, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-dichloro-phenyl; [0345] a compound of Formula (Ia) wherein A is
4-chloro-benzo, W is C(R4), R4 is methyl, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-dichloro-phenyl; [0346] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is methyl, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is 2-bromo-phenyl;
[0347] a compound of Formula (Ia) wherein A is benzo, W is C(R4),
R4 is methyl, X is S, R1 is ethoxy, R2 is ethoxy, R3
is H, L is CH2, and B is 2-fluoro-5-trifluoromethyl-phenyl; [0348] a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
H, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is
CH2, and B is 4-trifluoromethyl-phenyl; [0349] a compound of Formula
(Ia) wherein A is benzo, W is C(R4), R4 is H, X is S, R1
is isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2,
and B is 3-trifluoromethyl-phenyl; [0350] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is H, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
4-bromo-phenyl; [0351] a compound of Formula (Ia) wherein A is benzo, W
is C(R4), R4 is methyl, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is
5-chloro-benzo[1,3]dioxol-6-yl; [0352] a compound of Formula (Ia) wherein
A is benzo, W is C(R4), R4 is methyl, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3-(pyridin-4-yl)-phenyl; [0353] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is methyl, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
2-fluoro-3-chloro-5-trifluoromethyl-phenyl; [0354] a compound of Formula
(Ia) wherein A is benzo, W is C(R4), R4 is H, X is S, R1
is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
phenyl; [0355] a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is H, X is S, R1 is ethoxy, R2 is ethoxy,
R3 is H, L is CH2, and B is 3,4-difluoro-phenyl;

[0356] a compound of Formula (Ia) wherein A is benzo, W is C(R4),
R4 is methyl, X is S, R1 is ethoxy, R2 is ethoxy, R3
is H, L is CH2, and B is 2,4-dichloro-5-fluoro-phenyl; [0357] a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
methyl, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is
CH2, and B is 3-biphenyl; [0358] a compound of Formula (Ia) wherein
A is benzo, W is C(R4), R4 is H, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-dichloro-phenyl; [0359] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is methyl, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is CH3, L is CH2, and B is
3,4-difluoro-phenyl; [0360] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is H, X is S, R1 is ethoxy, R2
is ethoxy, R3 is H, L is CH2, and B is 2-fluoro-phenyl; [0361]
a compound of Formula (Ia) wherein A is benzo, W is C(R4), R4
is methyl, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L
is CH2, and B is 2-chloro-3-trifluoromethyl-phenyl; [0362] a
compound of Formula (Ia) wherein A is 6-methoxy-benzo, W is C(R4),
R4 is methyl, X is S, R1 is ethoxy, R2 is ethoxy, R3
is H, L is CH2, and B is 3,4-difluoro-phenyl; [0363] a compound of
Formula (Ia) wherein A is benzo, W is C(R4), R4 is H, X is S,
R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B
is naphthalen-2-yl; [0364] a compound of Formula (Ia) wherein A is
4-trifluoromethyl-benzo, W is C(R4), R4 is methyl, X is S,
R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B
is 3,4-difluoro-phenyl; [0365] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is H, X is S, R1 is ethoxy, R2
is ethoxy, R3 is H, L is CH2, and B is 2-chloro-phenyl; [0366]
a compound of Formula (Ia) wherein A is benzo, W is C(R4), R4
is H, X is O, R1 is ethoxy, R2 is ethoxy, R3 is H, L is
CH2, and B is 4-fluoro-phenyl; [0367] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is methyl, X is SO2,
R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B
is 3,4-difluoro-phenyl; [0368] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is H, X is S, R1 is ethoxy, R2
is ethoxy, R3 is H, L is CH2, and B is 2-methyl-phenyl; [0369]
a compound of Formula (Ia) wherein A is benzo, W is C(R4), R4
is H, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is
CH2, and B is benzothiophen-2-yl; [0370] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is methyl, X is S, R1
is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
4-trifluoromethyl-phenyl; [0371] a compound of Formula (Ia) wherein A is
5-chloro-benzo, W is C(R4), R4 is methyl, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3,4-difluoro-phenyl; [0372] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is bromo, L is CH2,
and B is 3,4-difluoro-phenyl; [0373] a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is H, X is S, R1 is ethoxy,
R2 is 2,6-dichloro-phenylmethoxy, R3 is H, L is absent, and B
is H; [0374] a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is H, X is S, R1 is ethoxy, R2 is ethoxy,
R3 is H, L is CH2, and B is 2,6-dichloro-phenyl; [0375] a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
H, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is
CH2, and B is 3,5-trifluoromethyl-phenyl; [0376] a compound of
Formula (Ia) wherein A is benzo, W is C(R4), R4 is H, X is S,
R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B
is 2-chloro-4-fluoro-phenyl; [0377] a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is methyl, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
2-chloro-5-trifluoromethyl-phenyl; [0378] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is H, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
2,3-dichloro-phenyl; [0379] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is methyl, X is S, R1 is
cyclohexyloxy, R2 is cyclohexyloxy, R3 is H, L is CH2, and
B is 3,4-difluoro-phenyl; [0380] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is H, X is S, R1 is ethoxy, R2
is ethoxy, R3 is H, L is CH2, and B is
2-trifluoromethyl-phenyl; [0381] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is methyl, X is S, R1 is ethoxy,
R2 is 2-(N,N-dimethylamino)-ethoxy, R3 is H, L is CH2, and
B is 3,4-difluoro-phenyl; [0382] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is H, X is S, R1 is ethoxy, R2
is 2-methyl-phenylmethoxy, R3 is H, L is absent, and B is H; [0383]
a compound of Formula (Ia) wherein A is benzo, W is C(R4), R4
is H, X is S, R1 is ethoxy, R2 is 2-chloro-phenylmethoxy,
R3 is H, L is absent, and B is H; [0384] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is methyl, X is S, R1
is ethoxy, R2 is methyl, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; [0385] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is H, X is S, R1 is ethoxy, R2
is 4-fluoro-phenylmethoxy, R3 is H, L is absent, and B is H; [0386]
a compound of Formula (Ia) wherein A is benzo, W is C(R4), R4
is H, X is S, R1 is ethoxy, R2 is 2-fluoro-phenylmethoxy,
R3 is H, L is absent, and B is H; [0387] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is H, X is S, R1 is
ethoxy, R2 is 2-bromo-phenylmethoxy, R3 is H, L is absent, and
B is H; [0388] a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is H, X is S, R1 is ethoxy, R2 is
phenylmethoxy, R3 is H, L is absent, and B is H; [0389] a compound
of Formula (Ia) wherein A is benzo, W is C(R4), R4 is H, X is
S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and
B is 5-chloro-benzo[1,3]dioxol-6-yl; [0390] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is methyl, X is S, R1
is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
2,5-di-trifluoromethyl-phenyl; [0391] a compound of Formula (Ia) wherein
A is benzo, W is C(R4), X is S, R4 is N,N-dimethylamino-methyl,
R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B
is 2-fluoro-phenyl; [0392] a compound of Formula (Ia) wherein A is benzo,
W is C(R4), R4 is methyl, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 2-biphenyl; [0393] a
compound of Formula (Ia) wherein A is 7-trifluoromethyl-benzo, W is
C(R4), R4 is methyl, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 3,4-difluoro-phenyl; [0394]
a compound of Formula (Ia) wherein A is 6-chloro-benzo, W is C(R4),
R4 is cyclopentyl, X is S, R1 is ethoxy, R2 is ethoxy,
R3 is H, L is CH2, and B is 3,4-difluoro-phenyl; [0395] a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
methyl, X is 5(O), R1 is ethoxy, R2 is ethoxy, R3 is H, L
is CH2, and B is 3,4-difluoro-phenyl; [0396] a compound of Formula
(Ia) wherein A is benzo, W is C(R4), R4 is cyclohexyl, X is S,
R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B
is 3,4-difluoro-phenyl; [0397] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is H, X is O, R1 is isopropyloxy,
R2 is isopropyloxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; [0398] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is H, X is S, R1 is isopropyloxy,
R2 is isopropyloxy, R3 is H, L is CH2, and B is
3,5-difluoro-phenyl; [0399] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is H, X is S, R1 is isopropyloxy,
R2 is isopropyloxy, R3 is H, L is CH2, and B is
2,3-difluoro-phenyl; [0400] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is O, R1 is isobutyl,
R2 is isobutyl, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; [0401] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is O, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3,4-difluoro-phenyl; [0402] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is H, X is S, R1 is isopropyloxy,
R2 is isopropyloxy, R3 is H, L is CH2, and B is
3-trifluoromethyl-4-fluoro-phenyl; [0403] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is H, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 2-fluoro-3-chloro-5-trifluoromethyl-phenyl; [0404] a compound of
Formula (Ia) wherein A is benzo, W is C(R4), R4 is bromo, X is
S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and
B is 3,4-difluoro-phenyl; [0405] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is 2-fluoro-pyridin-3-yl, X is S, R1
is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; [0406] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is 2,2-dimethyl-propyl, X is S, R1
is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; [0407] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is 2-fluoro-pyridin-5-yl, X is S, R1
is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; [0408] a compound of Formula (Ia) wherein A is
(2,3-b)pyridin-2-yl, W is C(R4), R4 is H, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; [0409] a compound of Formula (Ia) wherein A is
(2,3-b)pyridin-2-yl, W is C(R4), R4 is bromo, X is S, R1
is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; [0410] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is H, X is S, R1 is isopropyloxy,
R2 is isopropyloxy, R3 is H, L is CH2, and B is
3-fluoro-phenyl; [0411] a compound of Formula (Ia) wherein A is benzo, W
is C(R4), R4 is H, X is S, R1 is isopropyloxy, R2 is
isopropyloxy, R3 is H, L is CH2, and B is 3-chloro-phenyl;
[0412] diastereomer A, a compound of Formula (Ia) wherein A is benzo, W
is C(R4), R4 is methyl, X is S, R1 is ethoxy, R2 is
3-(4-methoxy-phenyl)-propyl, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; [0413] diastereomer B, a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is methyl, X is S, R1
is ethoxy, R2 is 3-(4-methoxy-phenyl)-propyl, R3 is H, L is
CH2, and B is 3,4-difluoro-phenyl; [0414] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3-chloro-phenyl; [0415] a compound of Formula (Ia) wherein A is benzo, W
is C(R4), R4 is bromo, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is
4-fluoro-3-trimethyl-phenyl; [0416] a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
4-chloro-3-trifluoromethyl-phenyl; [0417] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3-fluoro-5-trifluoromethyl-phenyl; [0418] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3-trifluoromethyl-phenyl; [0419] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
2-fluoro-3-trifluoromethyl-phenyl; [0420] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
2-fluoro-3-chloro-phenyl; [0421] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3-fluoro-4-trifluoromethyl-phenyl; [0422] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3-trifluoromethoxy-phenyl; [0423] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
2-fluoro-5-trifluoromethyl-phenyl; [0424] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
2-chloro-phenyl; [0425] a compound of Formula (Ia) wherein A is benzo, W
is C(R4), R4 is bromo, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is
2-chloro-5-trifluoromethyl-phenyl; [0426] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3-chloro-4-trifluoromethoxy-phenyl; [0427] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
2-fluoro-4-trifluoromethyl-phenyl; [0428] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
2-chloro-3-trifluoromethyl-phenyl; [0429] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3-trifluoromethyl-4-methoxy-phenyl; [0430] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
ethoxy, R2

is ethoxy, R3 is H, L is CH2, and B is
4-trifluoromethylthio-phenyl; [0431] a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
4-trifluoromethyl-phenyl; [0432] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
4-trifluoromethoxy-phenyl; [0433] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3-methoxy-4-fluoro-phenyl; [0434] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3-methoxy-4-fluoro-phenyl; [0435] a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3-fluoro-4-methoxy-phenyl; [0436] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3-fluoro-4-methoxy-phenyl; [0437] a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
2,3,5,6-tetrafluoro-4-methoxy-phenyl; [0438] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 2,3,5,6-tetrafluoro-4-methoxy-phenyl; [0439] a compound of Formula
(Ia) wherein A is benzo, W is C(R4), R4 is bromo, X is S,
R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B
is 2-fluoro-3-methoxy-phenyl; [0440] a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 2-fluoro-4-methoxy-phenyl; [0441] a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
2-fluoro-4-chloro-5-methoxy-phenyl; [0442] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 2-fluoro-4-chloro-5-methoxy-phenyl; [0443] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3-chloro-phenyl; [0444] a compound of Formula (Ia) wherein A is benzo,
W is C(R4), R4 is chloro, X is S, R1 is isopropyloxy,
R2 is isopropyloxy, R3 is H, L is CH2, and B is
3-trifluoromethyl-4-chloro-phenyl; [0445] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is chloro, X is S, R1
is isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2,
and B is 2-fluoro-3-trifluoromethyl-phenyl; [0446] a compound of Formula
(Ia) wherein A is benzo, W is C(R4), R4 is chloro, X is S,
R1 is isopropyloxy, R2 is isopropyloxy, R3 is H, L is
CH2, and B is 3-fluoro-5-trifluoromethyl-phenyl; [0447] a compound
of Formula (Ia) wherein A is benzo, W is C(R4), R4 is chloro, X
is S, R1 is isopropyloxy, R2 is isopropyloxy, R3 is H, L
is CH2, and B is 3-trifluoromethyl-phenyl; [0448] a compound of
Formula (Ia) wherein A is benzo, W is (R4), R4 is chloro, X is
S, R1 is isopropyloxy, R2 is isopropyloxy, R3 is H, L is
CH2, and B is 3,5-di-trifluoromethyl-phenyl; [0449] a compound of
Formula (Ia) wherein A is benzo, W is C(R4), R4 is chloro, X is
S, R1 is isopropyloxy, R2 is isopropyloxy, R3 is H, L is
CH2, and B is 2-fluoro-5-trifluoromethyl-phenyl; [0450] a compound
of Formula (Ia) wherein A is benzo, W is C(R4), R4 is chloro, X
is S, [0451] R1 is isopropyloxy, R2 is isopropyloxy, R3 is
H, L is CH2, and B is 2-trifluoromethyl-phenyl; [0452] a compound of
Formula (Ia) wherein A is benzo, W is C(R4), R4 is chloro, X is
S, R1 is isopropyloxy, R2 is isopropyloxy, R3 is H, L is
CH2, and B is 3-fluoro-4-trifluoromethyl-phenyl; [0453] a compound
of Formula (Ia) wherein A is benzo, W is C(R4), R4 is chloro, X
is S, R1 is isopropyloxy, R2 is isopropyloxy, R3 is H, L
is CH2, and B is 4-trifluoromethyl-phenyl; [0454] a compound of
Formula (Ia) wherein A is benzo, W is C(R4), R4 is chloro, X is
S, R1 is isopropyloxy, R2 is isopropyloxy, R3 is H, L is
CH2, and B is 3-trifluoromethyl-4-methoxy-phenyl; [0455] a compound
of Formula (Ia) wherein A is benzo, W is C(R4), R4 is chloro, X
is S, R1 is isopropyloxy, R2 is isopropyloxy, R3 is H, L
is CH2, and B is 2-chloro-3-trifluoromethyl-phenyl; [0456] a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
chloro, X is S, R1 is isopropyloxy, R2 is isopropyloxy, R3
is H, L is CH2, and B is 2-chloro-5-trifluoromethyl-phenyl; [0457] a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
chloro, X is S, R1 is isopropyloxy, R2 is isopropyloxy, R3
is H, L is CH2, and B is phenyl; [0458] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is chloro, X is S, R1
is isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2,
and B is 3-chloro-phenyl; [0459] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is chloro, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 4-chloro-phenyl; [0460] a compound of Formula (Ia) wherein A is benzo,
W is C(R4), R4 is chloro, X is S, R1 is isopropyloxy,
R2 is isopropyloxy, R3 is H, L is CH2, and B is
3-bromo-phenyl; [0461] a compound of Formula (Ia) wherein A is benzo, W
is C(R4), R4 is chloro, X is S, R1 is isopropyloxy,
R2 is isopropyloxy, R3 is H, L is CH2, and B is
2,6-dichloro-phenyl; [0462] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is chloro, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3-chloro-4-trifluoromethoxy-phenyl; [0463] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is chloro, X is S, R1
is isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2,
and B is 2-fluoro-3-chloro-phenyl; [0464] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is chloro, X is S, R1
is isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2,
and B is 3-chloro-5-fluoro-phenyl; [0465] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is chloro, X is S, R1
is isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2,
and B is 4-trifluoromethoxy-phenyl; [0466] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is chloro, X is S, R1
is isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2,
and B is 3-trifluoromethyl-4-fluoro-phenyl; [0467] a compound of Formula
(Ia) wherein A is benzo, W is C(R4), R4 is chloro, X is S,
R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B
is 3-fluoro-4-chloro-phenyl; [0468] a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3-fluoro-4-chloro-phenyl; [0469] a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is chloro, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 2-fluoro-4-trifluoromethyl-phenyl; [0470] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3-fluoro-phenyl; [0471] a compound of Formula (Ia) wherein A is benzo,
W is C(R4), R4 is bromo, X is S, R1 is isopropyloxy,
R2 is isopropyloxy, R3 is H, L is CH2, and B is
3,5-difluoro-phenyl; [0472] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 2,3-difluoro-phenyl; [0473] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 2-fluoro-3-chloro-5-trifluoromethyl-phenyl; [0474] a compound of
Formula (Ia) wherein A is benzo, W is C(R4), R4 is bromo, X is
S, R1 is isopropyloxy, R2 is isopropyloxy, R3 is H, L is
CH2, and B is 2-fluoro-phenyl; [0475] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 4-fluoro-phenyl; [0476] a compound of Formula (Ia) wherein A is
4-bromo-benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 2-fluoro-phenyl; [0477] a compound of Formula (Ia) wherein A is
6-bromo-benzyl, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 2-fluoro-phenyl; [0478] a compound of Formula (Ia) wherein A is
6-bromo-benzyl, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 4-fluoro-phenyl; [0479] a compound of Formula (Ia) wherein A is benzo,
W is C(R4), R4 is bromo, X is S, R1 is methoxy, R2 is
methoxy, R3 is H, L is CH2, and B is 3,4-difluoro-phenyl;
[0480] a compound of Formula (Ia) wherein A is 4-fluoro-benzo, W is
C(R4), R4 is methyl, X is O, R1 is isopropyloxy, R2
is isopropyloxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; [0481] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is s-butyl,
R2 is s-butyl, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; [0482] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is s-butyl,
R2 is s-butyl, R3 is H, L is OCH2, and B is
3,4-difluoro-phenyl; [0483] a compound of Formula (Ia) wherein A is
4-fluoro-benzo, W is C(R4), R4 is bromo, X is O, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3,4-difluoro-phenyl; [0484] a compound of Formula (Ia) wherein A is
4-fluoro-benzo, W is C(R4), R4 is bromo, X is O, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; [0485] a compound of Formula (Ia) wherein A is
(2,3-b)pyridin-2-yl, W is C(R4), R4 is bromo, X is S, R1
is isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2,
and B is 3,4-difluoro-phenyl; [0486] a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is thien-3-yl, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; [0487] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is n-butyloxy,
R2 is n-butyloxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; [0488] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is
2-(2-methoxy-ethoxy)-ethoxy, R2 is 2-(2-methoxy-ethoxy)-ethoxy,
R3 is H, L is CH2, and B is 3,4-difluoro-phenyl; [0489] a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
bromo, X is S, R1 is 3-methyl-butoxy, R2 is 3-methyl-butoxy,
R3 is H, L is CH2, and B is 3,4-difluoro-phenyl; [0490] a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
bromo, X is S, R1 is methoxycarbonyl-methoxy, R2 is
methoxycarbonyl-methoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; [0491] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is
2-acetoxy-ethoxy, R2 is 2-acetoxy-ethoxy, R3 is H, L is
CH2, and B is 3,4-difluoro-phenyl; [0492] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is phenyl, X is S, R1
is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; [0493] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is 2-hydroxy-phenyl, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; [0494] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is 2-fluoro-phenyl, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; [0495] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is 3-fluoro-phenyl, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; [0496] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is 3-aminocarbonyl-phenyl, X is S,
R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B
is 3,4-difluoro-phenyl; [0497] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is 3-methoxycarbonyl-phenyl, X is S,
R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B
is 3,4-difluoro-phenyl; [0498] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is 4-fluoro-phenyl, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; [0499] a compound of Formula (Ia) wherein A is
4-fluoro-benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3,4-difluoro-phenyl; [0500] a compound of Formula (Ia) wherein A is
4-fluoro-benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3-trifluoromethyl-4-fluoro-phenyl; [0501] a compound of Formula (Ia)
wherein A is 4-fluoro-benzo, W is C(R4), R4 is bromo, X is S,
R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B
is 3-trifluoromethyl-4-fluoro-phenyl; [0502] a compound of Formula (Ia)
wherein A is 4-fluoro-benzo, W is C(R4), R4 is bromo, X is S,
R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH

2, and B is 3,4-difluoro-phenyl; [0503] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3-hydroxy-4-fluoro-phenyl; [0504] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3-fluoro-4-hydroxy-phenyl; [0505] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3-fluoro-4-hydroxy-phenyl; [0506] a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
2,3,5,6-tetrafluoro-4-hydroxy-phenyl; [0507] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 2,3,5,6-tetrafluoro-4-hydroxy-phenyl; [0508] a compound of Formula
(Ia) wherein A is benzo, W is C(R4), R4 is bromo, X is S,
R1 is isopropyloxy, R2 is isopropyloxy, R3 is H, L is
CH2, and B is 2-fluoro-3-hydroxy-phenyl; [0509] a compound of
Formula (Ia) wherein A is benzo, W is C(R4), R4 is bromo, X is
S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and
B is 2-fluoro-4-chloro-5-hydroxy-phenyl; [0510] a compound of Formula
(Ia) wherein A is benzo, W is C(R4), R4 is bromo, X is S,
R1 is isopropyloxy, R2 is isopropyloxy, R3 is H, L is
CH2, and B is 2-fluoro-4-chloro-5-hydroxy-phenyl; [0511] a compound
of Formula (Ia) wherein A is benzo, W is C(R4), R4 is bromo, X
is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2,
and B is 3-trifluoromethyl-4-hydroxy-phenyl; [0512] enantiomer A, a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
bromo, X is S, R1 is isopropyloxy, R2 is isopropyloxy, R3
is H, L is CH2, and B is 3,4-difluoro-phenyl; [0513] enantiomer B, a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
bromo, X is S, R1 is isopropyloxy, R2 is isopropyloxy, R3
is H, L is CH2, and B is 3,4-difluoro-phenyl; [0514] enantiomer A, a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
bromo, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is
CH2, and B is 4-trifluoromethoxy-phenyl; [0515] enantiomer B, a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
bromo, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is
CH2, and B is 4-trifluoromethoxy-phenyl; [0516] a compound of
Formula (Ia) wherein A is benzo, W is C(R4), R4 is bromo, X is
S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and
B is 4-fluoro-phenyl; [0517] enantiomer A, a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
4-fluoro-phenyl; [0518] enantiomer B, a compound of Formula (Ia) wherein
A is benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is 4-fluoro-phenyl;
[0519] a compound of Formula (Ia) wherein A is benzo, W is C(R4),
R4 is bromo, X is S, R1 is isopropyloxy, R2 is
isopropyloxy, R3 is H, L is CH2, and B is
3-trifluoromethyl-4-fluoro-phenyl; [0520] enantiomer A, a compound of
Formula (Ia) wherein A is benzo, W is C(R4), R4 is bromo, X is
S, R1 is isopropyloxy, R2 is isopropyloxy, R3 is H, L is
CH2, and B is 3-trifluoromethyl-4-fluoro-phenyl; [0521] enantiomer
B, a compound of Formula (Ia) wherein A is benzo, W is C(R4),
R4 is bromo, X is S, R1 is isopropyloxy, R2 is
isopropyloxy, R3 is H, L is CH2, and B is
3-trifluoromethyl-4-fluoro-phenyl; [0522] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3-chloro-4-fluoro-phenyl; [0523] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
2-trifluoromethyl-4-fluoro-phenyl; [0524] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3-trimethylthio-phenyl; [0525] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
4-methylthio-phenyl; [0526] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3-chloro-4-fluoro-phenyl; [0527] a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 2-trifluoromethyl-4-fluoro-phenyl; [0528] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3-trifluoromethylthio-phenyl; [0529] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 4-methylthio-phenyl; [0530] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 4-methylsulfonyl-phenyl; [0531] a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is chloro, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3-chloro-4-fluoro-phenyl; [0532] a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is chloro, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 2-trifluoromethyl-4-fluoro-phenyl; [0533] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is chloro, X is S, R1
is isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2,
and B is 3-trifluoromethylthio-phenyl; [0534] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is chloro, X is S, R1
is isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2,
and B is 4-methylthio-phenyl; [0535] a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is 4-chloro-phenyl;
[0536] a compound of Formula (Ia) wherein A is benzo, W is C(R4),
R4 is bromo, X is S, R1 is ethoxy, R2 is ethoxy, R3
is H, L is CH2, and B is 3-fluoro-4-chloro-phenyl; [0537] a compound
of Formula (Ia) wherein A is benzo, W is C(R4), R4 is bromo, X
is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2,
and B is 3-chloro-5-fluoro-phenyl; [0538] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
2-trifluoromethyl-phenyl; [0539] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3,5-di-trifluoromethyl-phenyl; [0540] a compound of Formula (Ia) wherein
A is benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
4-trifluoromethylsulfonyl-phenyl; [0541] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 4-trifluoromethylsulfonyl-phenyl; [0542] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is chloro, X is S, R1
is isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2,
and B is 4-trifluoromethylsulfonyl-phenyl; [0543] a compound of Formula
(Ia) wherein A is benzo, W is C(R4), R4 is H, X is O, R1
is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; [0544] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is O, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; [0545] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3-chloro-2-fluoro-phenyl; [0546] a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 2-chloro-3-trifluoromethyl-phenyl; [0547] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is chloro, X is S, R1
is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
2-chloro-phenyl; [0548] a compound of Formula (Ia) wherein A is benzo, W
is C(R4), R4 is chloro, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 3-trifluoromethoxy-phenyl;
[0549] a compound of Formula (Ia) wherein A is benzo, W is C(R4),
R4 is chloro, X is S, R1 is ethoxy, R2 is ethoxy, R3
is H, L is CH2, and B is 3-chloro-4-trifluoromethoxy-phenyl; [0550]
a compound of Formula (Ia) wherein A is benzo, W is C(R4), R4
is chloro, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L
is CH2, and B is 3-chloro-2-fluoro-phenyl; [0551] a compound of
Formula (Ia) wherein A is benzo, W is C(R4), R4 is chloro, X is
S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and
B is 3-fluoro-4-trifluoromethyl-phenyl; [0552] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is chloro, X is S, R1
is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
2-chloro-5-trifluoromethyl-phenyl; [0553] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is chloro, X is S, R1
is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3-bromo-phenyl; [0554] a compound of Formula (Ia) wherein A is benzo, W
is C(R4), R4 is chloro, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 3-chloro-5-fluoro-phenyl;
[0555] a compound of Formula (Ia) wherein A is benzo, W is C(R4),
R4 is chloro, X is S, R1 is ethoxy, R2 is ethoxy, R3
is H, L is CH2, and B is 4-trifluoromethoxy-phenyl; [0556] a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
chloro, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is
CH2, and B is 3-fluoro-5-trifluoromethyl-phenyl; [0557] a compound
of Formula (Ia) wherein A is benzo, W is C(R4), R4 is chloro, X
is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2,
and B is 2-trifluoromethyl-phenyl; [0558] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is chloro, X is S, R1
is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
2-chloro-3-trifluoromethyl-phenyl; [0559] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is chloro, X is S, R1
is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
2-fluoro-3-trifluoromethyl-phenyl; [0560] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is chloro, X is S, R1
is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3,5-di-trifluoromethyl-phenyl; [0561] a compound of Formula (Ia) wherein
A is benzo, W is C(R4), R4 is chloro, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
4-trifluoromethylthio-phenyl; [0562] a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is chloro, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is 4-fluoro-phenyl;
[0563] a compound of Formula (Ia) wherein A is benzo, W is C(R4),
R4 is chloro, X is S, R1 is ethoxy, R2 is ethoxy, R3
is H, L is CH2, and B is 4-trifluoromethyl-phenyl; [0564] a compound
of Formula (Ia) wherein A is benzo, W is C(R4), R4 is chloro, X
is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2,
and B is 2-fluoro-5-trifluoromethyl-phenyl; [0565] a compound of Formula
(Ia) wherein A is benzo, W is C(R4), R4 is chloro, X is S,
R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B
is 4-chloro-3-trifluoromethyl-phenyl; [0566] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 4-chloro-phenyl; [0567] a compound of Formula (Ia) wherein A is benzo,
W is C(R4), R4 is bromo, X is S, R1 is isopropyloxy,
R2 is isopropyloxy, R3 is H, L is CH2, and B is
2-fluoro-4-trifluoromethyl-phenyl; [0568] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is chloro, X is S, R1
is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3-chloro-phenyl; [0569] a compound of Formula (Ia) wherein A is benzo, W
is C(R4), R4 is chloro, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is
2-fluoro-4-trifluoromethyl-phenyl; [0570] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is chloro, X is S, R1
is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
4-methoxy-3-trifluoromethyl-phenyl; [0571] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is chloro, X is S, R1
is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
4-chloro-phenyl; [0572] a compound of Formula (Ia) wherein A is benzo, W
is C(R4), R4 is chloro, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is
4-fluoro-3-trifluoromethyl-phenyl; [0573] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3-bromo-phenyl; [0574] a compound of Formula (Ia) wherein A is benzo, W
is C(R4), R4 is chloro, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is
3-trifluoromethylthio-phenyl; [0575] a compound of Formula (Ia) wherein A
is benzo, W is C(R

4), R4 is chloro, X is S, R1 is ethoxy, R2 is ethoxy,
R3 is H, L is CH2, and B is 3-chloro-4-fluoro-phenyl; [0576] a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
chloro, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is
CH2, and B is 4-fluoro-3-trifluoromethyl-phenyl; [0577] a compound
of Formula (Ia) wherein A is benzo, W is C(R4), R4 is chloro, X
is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2,
and B is 4-methylthio-phenyl; [0578] a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is chloro, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
4-trifluoromethylsulfonyl-phenyl; [0579] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is chloro, X is S, R1
is isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2,
and B is 3-trifluoromethoxy-phenyl; [0580] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is chloro, X is S, R1
is isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2,
and B is 4-chloro-3-fluoro-phenyl; [0581] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is chloro, X is S, R1
is isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2,
and B is 5-chloro-2-fluoro-phenyl; [0582] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is chloro, X is S, R1
is isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2,
and B is 4-trifluoromethylthio-phenyl; [0583] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is chloro, X is S, R1
is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
5-chloro-2-fluoro-phenyl; [0584] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is chloro, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 4-fluoro-phenyl; [0585] a compound of Formula (Ia) wherein A is benzo,
W is C(R4), R4 is bromo, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 5-chloro-2-fluoro-phenyl;
[0586] a compound of Formula (Ia) wherein A is benzo, W is C(R4),
R4 is bromo, X is S, R1 is isopropyloxy, R2 is
isopropyloxy, R3 is H, L is CH2, and B is
5-chloro-2-fluoro-phenyl; [0587] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is 3-cyano-phenyl;
[0588] a compound of Formula (Ia) wherein A is benzo, W is C(R4),
R4 is bromo, X is S, R1 is ethoxy, R2 is ethoxy, R3
is H, L is CH2, and B is 3-pyrrol-1-yl-phenyl; [0589] a compound of
Formula (Ia) wherein A is benzo, W is C(R4), R4 is bromo, X is
S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and
B is 4-difluoromethoxy-phenyl; [0590] a compound of Formula (Ia) wherein
A is benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is 4-cyano-phenyl;
[0591] a compound of Formula (Ia) wherein A is benzo, W is C(R4),
R4 is bromo, X is S, R1 is ethoxy, R2 is ethoxy, R3
is H, L is CH2, and B is 3-methoxycarbonyl-phenyl; [0592] a compound
of Formula (Ia) wherein A is benzo, W is C(R4), R4 is bromo, X
is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2,
and B is 3-methoxy-phenyl; [0593] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is 3-nitro-phenyl;
[0594] a compound of Formula (Ia) wherein A is benzo, W is C(R4),
R4 is bromo, X is S, R1 is ethoxy, R2 is ethoxy, R3
is H, L is CH2, and B is 3-hydroxy-phenyl; [0595] a compound of
Formula (Ia) wherein A is benzo, W is C(R4), R4 is bromo, X is
S, R1 is isopropyloxy, R2 is isopropyloxy, R3 is H, L is
CH2, and B is 3-methoxy-phenyl; [0596] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3-amino-phenyl; [0597] a compound of Formula (Ia) wherein A is benzo, W
is C(R4), R4 is bromo, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 3,5-dimethoxy-phenyl;
[0598] a compound of Formula (Ia) wherein A is benzo, W is C(R4),
R4 is bromo, X is S, R1 is ethoxy, R2 is ethoxy, R3
is H, L is CH2, and B is 2-methoxy-phenyl; [0599] a compound of
Formula (Ia) wherein A is benzo, W is C(R4), R4 is bromo, X is
S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and
B is 4-methoxy-phenyl; [0600] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3,5-dihydroxy-phenyl; [0601] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
2-hydroxy-phenyl; [0602] a compound of Formula (Ia) wherein A is benzo, W
is C(R4), R4 is bromo, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 4-hydroxy-phenyl; [0603] a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
bromo, X is S, R1 is isopropyloxy, R2 is isopropyloxy, R3
is H, L is CH2, and B is 3-hydroxy-phenyl; [0604] a compound of
Formula (Ia) wherein A is benzo, W is C(R4), R4 is bromo, X is
S, R1 is isopropyloxy, R2 is isopropyloxy, R3 is H, L is
CH2, and B is 4-methoxy-3-trifluoromethyl-phenyl; [0605] a compound
of Formula (Ia) wherein A is benzo, W is C(R4), R4 is bromo, X
is N(t-butoxycarbonyl), R1 is isopropyloxy, R2 is isopropyloxy,
R3 is H, L is CH2, and B is 4-fluoro-3-trifluoromethyl-phenyl;
[0606] a compound of Formula (Ia) wherein A is benzo, W is C(R4),
R4 is bromo, X is N(methyl), R1 is isopropyloxy, R2 is
isopropyloxy, R3 is H, L is CH2, and B is
4-fluoro-3-trifluoromethyl-phenyl; [0607] a compound of Formula (Ia)
wherein A is 3-trifluoromethyl-4-fluoro-benzo, W is C(R4), R4
is bromo, X is N(n-propyl), R1 is isopropyloxy, R2 is
isopropyloxy, R3 is H, L is CH2, and B is
4-fluoro-3-trifluoromethyl-phenyl; [0608] a compound of Formula (Ia)
wherein A is 3-trifluoromethyl-4-fluoro-benzo, W is C(R4), R4
is bromo, X is N(methanesulfonyl), R1 is isopropyloxy, R2 is
isopropyloxy, R3 is H, L is CH2, and B is
4-fluoro-3-trifluoromethyl-phenyl; [0609] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is
N(methylcarbonyl), R1 is isopropyloxy, R2 is isopropyloxy,
R3 is H, L is CH2, and B is 4-fluoro-3-trifluoromethyl-phenyl;
[0610] a compound of Formula (Ia) wherein A is benzo, W is C(R4),
R4 is bromo, X is N(n-propylsulfonyl), R1 is isopropyloxy,
R2 is isopropyloxy, R3 is H, L is CH2, and B is
4-fluoro-3-trifluoromethyl-phenyl; [0611] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is H, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is absent, L is ═CH--
taken to form an alkene with the phosphorus-bearing adjacent atom, and B
is 3,4-difluoro-phenyl; [0612] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is absent, L is ═CH--
taken to form an alkene with the phosphorus-bearing adjacent atom, and B
is 3,4-difluoro-phenyl; [0613] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 2-fluoro-5-trifluoromethyl-phenyl; and [0614] a compound of Formula
(Ia) wherein A is benzo, W is C(R4), R4 is bromo, X is S,
R1 is isopropyloxy, R2 is isopropyloxy, R3 is H, L is
CH2, and B is 4-trifluoromethyl-phenyl.

[0615] Further embodiments of the present invention are directed to a
compound of Formula (Ia)

##STR00019##

selected from the group consisting of [0616] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is methyl, X is S, R1
is isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2,
and B is 3,4-difluoro-phenyl; [0617] a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is i-propyl, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; [0618] a compound of Formula (Ia) wherein A is
4-fluoro-benzo, W is C(R4), R4 is methyl, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; [0619] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is methyl, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is 3-chloro-phenyl;
[0620] a compound of Formula (Ia) wherein A is benzo, W is C(R4),
R4 is cyclopentyl, X is S, R1 is ethoxy, R2 is ethoxy,
R3 is H, L is CH2, and B is 3,4-difluoro-phenyl; [0621] a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
methyl, X is S, R1 is ethoxy, R2 is isobutyl, R3 is H, L
is CH2, and B is 3,4-difluoro-phenyl; [0622] a compound of Formula
(Ia) wherein A is benzo, W is C(R4), R4 is methyl, X is S,
R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B
is 3-fluoro-phenyl; [0623] a compound of Formula (Ia) wherein A is
7-fluoro-benzo, W is C(R4), R4 is methyl, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; [0624] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is methyl, X is O, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; [0625] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is methyl, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
2,3-difluoro-phenyl; [0626] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is methyl, X is O, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3,4-difluoro-phenyl; [0627] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is chloro, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3,4-difluoro-phenyl; [0628] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is methyl, X is S, R1 is isobutyl,
R2 is isobutyl, R3 is H, L is OCH2, and B is
3,4-difluoro-phenyl; [0629] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is methyl, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; [0630] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3,4-difluoro-phenyl; [0631] a compound of Formula (Ia) wherein A is
6-fluoro-benzo, W is C(R4), R4 is methyl, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; [0632] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is methyl, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3,5-difluoro-phenyl; [0633] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is methyl, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is 3-methyl-phenyl;
[0634] a compound of Formula (Ia) wherein A is benzo, W is C(R4),
R4 is i-propyl, X is S, R1 is isopropyloxy, R2 is
isopropyloxy, R3 is H, L is CH2, and B is 3,4-difluoro-phenyl;
[0635] a compound of Formula (Ia) wherein A is benzo, W is C(R4),
R4 is cyclopropyl, X is S, R1 is isopropyloxy, R2 is
isopropyloxy, R3 is H, L is CH2, and B is 3,4-difluoro-phenyl;
[0636] a compound of Formula (Ia) wherein A is benzo, W is C(R4),
R4 is methyl, X is S, R1 is ethoxy, R2 is ethoxy, R3
is H, L is CH2, and B is 3,4-dichloro-phenyl; [0637] a compound of
Formula (Ia) wherein A is benzo, W is C(R4), R4 is methyl, X is
S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and
B is 2-fluoro-phenyl; [0638] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is methyl, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
2-fluoro-3-chloro-phenyl; [0639] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-dichloro-phenyl; [0640] a compound of Formula (Ia) wherein A is
benzo, W is N, X is S, R1 is isopropyloxy, R2 is isopropyloxy,
R3 is H, L is CH2, and B is 3,4-difluoro-phenyl;

[0641] a compound of Formula (Ia) wherein A is benzo, W is C(R4),
R4 is methyl, X is S, R1 is ethoxy, R2 is ethoxy, R3
is H, L is CH2, and B is 2-methyl-phenyl; [0642] a compound of
Formula (Ia) wherein A is benzo, W is C(R4), R4 is methyl, X is
S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and
B is 2-chloro-4-fluoro-phenyl; [0643] a compound of Formula (Ia) wherein
A is benzo, W is C(R4), R4 is methyl, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
2-chloro-3,5-difluoro-phenyl; [0644] a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is cyclopropyl, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; [0645] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is methyl, X is S, R1 is ethoxy,
R2 is methyl, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; [0646] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is methyl, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3-trifluoromethyl-4-fluoro-phenyl; [0647] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is methyl, X is S, R1
is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3-methoxy-phenyl; [0648] a compound of Formula (Ia) wherein A is benzo, W
is C(R4), R4 is methyl, X is S, R1 is isobutyl, R2 is
isobutyl, R3 is H, L is CH2, and B is 3,4-difluoro-phenyl;
[0649] a compound of Formula (Ia) wherein A is (2,3-b)pyridin-2-yl, W is
C(R4), R4 is methyl, X is S, R1 is isopropyloxy, R2
is isopropyloxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; [0650] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is methyl, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
2,3-dichloro-phenyl; [0651] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is methyl, X is S, R1 is ethoxy,
R2 is isobutyl, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; [0652] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is methyl, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
2-fluoro-3-trifluoromethyl-phenyl; [0653] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is cyclopentyl, X is S,
[0654] R1 is isopropyloxy, R2 is isopropyloxy, R3 is H, L
is CH2, and B is 3,4-difluoro-phenyl; [0655] a compound of Formula
(Ia) wherein A is benzo, W is C(R4), R4 is H, X is S, R1
is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3-trifluoromethyl-phenyl; [0656] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is methyl, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is 3-bromo-phenyl;
[0657] a compound of Formula (Ia) wherein A is benzo, W is C(R4),
R4 is cyclobutyl, X is S, R1 is ethoxy, R2 is ethoxy,
R3 is H, L is CH2, and B is 3,4-difluoro-phenyl; [0658] a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
methyl, X is S, R1 is n-propyl, R2 is n-propyl, R3 is H, L
is OCH2, and B is 3,4-difluoro-phenyl; [0659] a compound of Formula
(Ia) wherein A is benzo, W is C(R4), R4 is trifluoromethyl, X
is S, R1 is isopropyloxy, R2 is isopropyloxy, R3 is H, L
is CH2, and B is 3,4-difluoro-phenyl; [0660] a compound of Formula
(Ia) wherein A is benzo, W is C(R4), R4 is methyl, X is S,
R1 is n-propyl, R2 is n-propyl, R3 is H, L is CH2,
and B is 3,4-difluoro-phenyl; [0661] a compound of Formula (Ia) wherein A
is 5-fluoro-benzo, W is C(R4), R4 is methyl, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; [0662] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is methyl, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is naphthalen-2-yl;
[0663] a compound of Formula (Ia) wherein A is benzo, W is C(R4),
R4 is methyl, X is S, R1 is ethoxy, R2 is ethoxy, R3
is H, L is CH2, and B is 2,5-dichloro-phenyl; [0664] a compound of
Formula (Ia) wherein A is benzo, W is C(R4), R4 is methyl, X is
S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and
B is 2-chloro-phenyl; [0665] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is methyl, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3-trifluoromethyl-4-chloro-phenyl; [0666] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is methyl, X is S, R1
is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
4-fluoro-phenyl; [0667] a compound of Formula (Ia) wherein A is benzo, W
is C(R4), R4 is H, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 4-fluoro-phenyl; [0668] a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
methyl, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is
CH2, and B is 3-trifluoromethyl-phenyl; [0669] a compound of Formula
(Ia) wherein A is benzo, W is C(R4), R4 is methyl, X is S,
R1 is 2,2-dimethyl-propyl, R2 is 2,2-dimethyl-propyl, R3
is H, L is CH2, and B is 3,4-difluoro-phenyl; [0670] a compound of
Formula (Ia) wherein A is benzo, W is C(R4), R4 is methyl, X is
S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and
B is 2,6-dichloro-phenyl; [0671] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is methyl, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
4-trifluoromethoxy-phenyl; [0672] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is methyl, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3-fluoro-5-trifluoromethyl-phenyl; [0673] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is methyl, X is S, R1
is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3-trifluoromethoxy-phenyl; [0674] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is H, X is S, R1 is ethoxy, R2
is ethoxy, R3 is H, L is CH2, and B is
3-fluoro-4-trifluoromethyl-phenyl; [0675] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is methyl, X is S, R1
is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
2-trifluoromethyl-phenyl; [0676] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is methyl, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
2-fluoro-3-methyl-6-chloro-phenyl; [0677] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is methyl, X is S, R1
is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
2-trifluoromethoxy-phenyl; [0678] a compound of Formula (Ia) wherein A is
5-methyl-benzo, W is C(R4), R4 is methyl, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3,4-difluoro-phenyl; [0679] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is H, X is S, R1 is isopropyloxy,
R2 is isopropyloxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; [0680] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is phenyl, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-dichloro-phenyl; [0681] a compound of Formula (Ia) wherein A is
4-chloro-benzo, W is C(R4), R4 is methyl, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-dichloro-phenyl; [0682] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is methyl, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is 2-bromo-phenyl;
[0683] a compound of Formula (Ia) wherein A is benzo, W is C(R4),
R4 is methyl, X is S, R1 is ethoxy, R2 is ethoxy, R3
is H, L is CH2, and B is 2-fluoro-5-trifluoromethyl-phenyl; [0684] a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
H, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is
CH2, and B is 4-trifluoromethyl-phenyl; [0685] a compound of Formula
(Ia) wherein A is benzo, W is C(R4), R4 is H, X is S, R1
is isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2,
and B is 3-trifluoromethyl-phenyl; [0686] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is H, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
4-bromo-phenyl; [0687] a compound of Formula (Ia) wherein A is benzo, W
is C(R4), R4 is methyl, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is
5-chloro-benzo[1,3]dioxol-6-yl; [0688] a compound of Formula (Ia) wherein
A is benzo, W is C(R4), R4 is methyl, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3-(pyridin-4-yl)-phenyl; [0689] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is methyl, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
2-fluoro-3-chloro-5-trifluoromethyl-phenyl; [0690] a compound of Formula
(Ia) wherein A is benzo, W is C(R4), R4 is H, X is S, R1
is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
phenyl; [0691] a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is H, X is S, R1 is ethoxy, R2 is ethoxy,
R3 is H, L is CH2, and B is 3,4-difluoro-phenyl; [0692] a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
methyl, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is
CH2, and B is 2,4-dichloro-5-fluoro-phenyl; [0693] a compound of
Formula (Ia) wherein A is benzo, W is C(R4), R4 is methyl, X is
S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and
B is 3-biphenyl; [0694] a compound of Formula (Ia) wherein A is benzo, W
is C(R4), R4 is H, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 3,4-dichloro-phenyl; [0695]
a compound of Formula (Ia) wherein A is benzo, W is C(R4), R4
is methyl, X is S, R1 is ethoxy, R2 is ethoxy, R3 is
CH3, L is CH2, and B is 3,4-difluoro-phenyl; [0696] a compound
of Formula (Ia) wherein A is benzo, W is C(R4), R4 is H, X is
S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and
B is 2-fluoro-phenyl; [0697] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is methyl, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
2-chloro-3-trifluoromethyl-phenyl; [0698] a compound of Formula (Ia)
wherein A is 6-methoxy-benzo, W is C(R4), R4 is methyl, X is S,
R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B
is 3,4-difluoro-phenyl; [0699] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is H, X is S, R1 is ethoxy, R2
is ethoxy, R3 is H, L is CH2, and B is naphthalen-2-yl; [0700]
a compound of Formula (Ia) wherein A is 4-trifluoromethyl-benzo, W is
C(R4), R4 is methyl, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 3,4-difluoro-phenyl; [0701]
a compound of Formula (Ia) wherein A is benzo, W is C(R4), R4
is H, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is
CH2, and B is 2-chloro-phenyl; [0702] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is H, X is O, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
4-fluoro-phenyl; [0703] a compound of Formula (Ia) wherein A is benzo, W
is C(R4), R4 is methyl, X is SO2, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; [0704] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is H, X is S, R1 is ethoxy, R2
is ethoxy, R3 is H, L is CH2, and B is 2-methyl-phenyl; [0705]
a compound of Formula (Ia) wherein A is benzo, W is C(R4), R4
is H, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is
CH2, and B is benzothiophen-2-yl; [0706] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is methyl, X is S, R1
is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
4-trifluoromethyl-phenyl; [0707] a compound of Formula (Ia) wherein A is
5-chloro-benzo, W is C(R4), R4 is methyl, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3,4-difluoro-phenyl; [0708] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is bromo, L is CH2,
and B is 3,4-difluoro-phenyl; [0709] a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is H, X is S, R1 is ethoxy,
R2 is 2,6-dichloro-phenylmethoxy, R3 is H, L is absent, and B
is H; [0710] a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is H, X is S, R1 is ethoxy, R2 is ethoxy,
R3 is H, L is CH2, and B is 2,6-dichloro-phenyl; [0711] a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
H, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is
CH2, and B is 3,5-trifluoromethyl-phenyl; [0712] a compound of
Formula (Ia) wherein A is benzo, W is C(R4), R4 is H, X is S,
R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B
is 2-chloro-4-fluoro-phenyl; [0713] a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is methyl, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
2-chloro-5-trifluoromethyl-phenyl; [0714] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is H, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
2,3-dichloro-phenyl; [0715] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is methyl, X is S, R1 is
cyclohexyloxy, R2 is cyclohexyloxy, R3 is H, L is CH2, and
B is 3,4-difluoro-phenyl; [0716] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is H, X is S, R1 is ethoxy, R2
is ethoxy, R3 is H, L is CH2, and B is
2-trifluoromethyl-phenyl; [0717] a compound of Formula (Ia) wherein A is
benzo, W is C(R

4), R4 is methyl, X is S, R1 is ethoxy, R2 is
2-(N,N-dimethylamino)-ethoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; [0718] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is H, X is S, R1 is ethoxy, R2
is 2-methyl-phenylmethoxy, R3 is H, L is absent, and B is H; [0719]
a compound of Formula (Ia) wherein A is benzo, W is C(R4), R4
is H, X is S, R1 is ethoxy, R2 is 2-chloro-phenylmethoxy,
R3 is H, L is absent, and B is H; [0720] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is methyl, X is S, R1
is ethoxy, R2 is methyl, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; [0721] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is H, X is S, R1 is ethoxy, R2
is 4-fluoro-phenylmethoxy, R3 is H, L is absent, and B is H; [0722]
a compound of Formula (Ia) wherein A is benzo, W is C(R4), R4
is H, X is S, R1 is ethoxy, R2 is 2-fluoro-phenylmethoxy,
R3 is H, L is absent, and B is H; [0723] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3-methoxy-4-fluoro-phenyl; [0724] a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
2-hydroxy-phenyl; [0725] a compound of Formula (Ia) wherein A is benzo, W
is C(R4), R4 is bromo, X is S, R1 is isopropyloxy, R2
is isopropyloxy, R3 is H, L is CH2, and B is
3-trifluoromethyl-4-fluoro-phenyl; [0726] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3-hydroxy-phenyl; [0727] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 2-fluoro-3-hydroxy-phenyl; [0728] a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 5-chloro-2-fluoro-phenyl; [0729] a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3-methoxy-4-fluoro-phenyl; [0730] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3-chloro-phenyl; [0731] a compound of Formula (Ia) wherein A is benzo,
W is C(R4), R4 is bromo, X is S, R1 is isopropyloxy,
R2 is isopropyloxy, R3 is H, L is CH2, and B is
2,3,5,6-tetrafluoro-4-methoxy-phenyl; [0732] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 2-fluoro-4-methoxy-phenyl; [0733] a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3-chloro-4-fluoro-phenyl; [0734] a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 4-trifluoromethylsulfonyl-phenyl; [0735] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3-methoxy-phenyl; [0736] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is 4-chloro-phenyl;
[0737] a compound of Formula (Ia) wherein A is benzo, W is C(R4),
R4 is bromo, X is S, R1 is ethoxy, R2 is ethoxy, R3
is H, L is CH2, and B is 3-chloro-5-fluoro-phenyl; [0738] a compound
of Formula (Ia) wherein A is benzo, W is C(R4), R4 is bromo, X
is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2,
and B is 3,5-dimethoxy-phenyl; [0739] a compound of Formula (Ia) wherein
A is benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
5-chloro-2-fluoro-phenyl; [0740] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3-hydroxy-4-fluoro-phenyl; [0741] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3-chloro-4-fluoro-phenyl; [0742] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
4-trifluoromethyl-phenyl; [0743] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
2-methoxy-phenyl; [0744] a compound of Formula (Ia) wherein A is benzo, W
is C(R4), R4 is chloro, X is S, R1 is isopropyloxy,
R2 is isopropyloxy, R3 is H, L is CH2, and B is
4-trifluoromethylthio-phenyl; [0745] a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is chloro, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 4-trifluoromethylsulfonyl-phenyl; [0746] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3,4-difluoro-phenyl; [0747] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3-methoxy-phenyl; [0748] a compound of Formula (Ia) wherein A is benzo, W
is C(R4), R4 is bromo, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 3-bromo-phenyl; [0749] a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
chloro, X is S, R1 is isopropyloxy, R2 is isopropyloxy, R3
is H, L is CH2, and B is 2-fluoro-4-trifluoromethyl-phenyl; [0750] a
compound of Formula (Ia) wherein A is 4-fluoro-benzo, W is C(R4),
R4 is bromo, X is S, R1 is isopropyloxy, R2 is
isopropyloxy, R3 is H, L is CH2, and B is 3,4-difluoro-phenyl;
[0751] a compound of Formula (Ia) wherein A is benzo, W is C(R4),
R4 is bromo, X is S, R1 is ethoxy, R2 is ethoxy, R3
is H, L is CH2, and B is 3-hydroxy-phenyl; [0752] a compound of
Formula (Ia) wherein A is benzo, W is C(R4), R4 is bromo, X is
S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and
B is 2-fluoro-3-methoxy-phenyl; [0753] a compound of Formula (Ia) wherein
A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3-fluoro-4-chloro-phenyl; [0754] a compound of Formula (Ia) wherein A
is 4-fluoro-benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3-trifluoromethyl-4-fluoro-phenyl; [0755] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is chloro, X is S, R1
is isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2,
and B is 3-chloro-4-fluoro-phenyl; [0756] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 2-chloro-3-trifluoromethyl-phenyl; [0757] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3-fluoro-4-methoxy-phenyl; [0758] a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is 4-fluoro-phenyl;
[0759] a compound of Formula (Ia) wherein A is benzo, W is C(R4),
R4 is bromo, X is S, R1 is isopropyloxy, R2 is
isopropyloxy, R3 is H, L is CH2, and B is
3-trifluoromethyl-4-fluoro-phenyl; [0760] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3-fluoro-phenyl; [0761] a compound of Formula (Ia) wherein A is benzo,
W is C(R4), R4 is chloro, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 3-chloro-4-fluoro-phenyl;
[0762] a compound of Formula (Ia) wherein A is benzo, W is C(R4),
R4 is bromo, X is S, R1 is isopropyloxy, R2 is
isopropyloxy, R3 is H, L is CH2, and B is 2,3-difluoro-phenyl;
[0763] a compound of Formula (Ia) wherein A is benzo, W is C(R4),
R4 is bromo, X is S, R1 is ethoxy, R2 is ethoxy, R3
is H, L is CH2, and B is 3-nitro-phenyl; [0764] a compound of
Formula (Ia) wherein A is benzo, W is C(R4), R4 is bromo, X is
S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and
B is 3-pyrrol-1-yl-phenyl; [0765] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
4-methoxy-phenyl; [0766] a compound of Formula (Ia) wherein A is benzo, W
is C(R4), R4 is bromo, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is
4-trifluoromethylthio-phenyl; [0767] a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
4-fluoro-3-trimethyl-phenyl; [0768] a compound of Formula (Ia) wherein A
is 4-fluoro-benzo, W is C(R4), R4 is bromo, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; [0769] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is 4-fluoro-phenyl;
[0770] a compound of Formula (Ia) wherein A is benzo, W is C(R4),
R4 is bromo, X is S, R1 is isopropyloxy, R2 is
isopropyloxy, R3 is H, L is CH2, and B is 4-methylthio-phenyl;
[0771] a compound of Formula (Ia) wherein A is benzo, W is C(R4),
R4 is bromo, X is S, R1 is ethoxy, R2 is ethoxy, R3
is H, L is CH2, and B is 3-fluoro-4-chloro-phenyl; [0772] a compound
of Formula (Ia) wherein A is benzo, W is C(R4), R4 is bromo, X
is S, R1 is isopropyloxy, R2 is isopropyloxy, R3 is H, L
is CH2, and B is 4-fluoro-phenyl; [0773] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
4-trifluoromethoxy-phenyl; [0774] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3-chloro-2-fluoro-phenyl; [0775] a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3-trifluoromethylthio-phenyl; [0776] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 2-fluoro-phenyl; [0777] a compound of Formula (Ia) wherein A is benzo,
W is C(R4), R4 is chloro, X is S, R1 is isopropyloxy,
R2 is isopropyloxy, R3 is H, L is CH2, and B is
5-chloro-2-fluoro-phenyl; [0778] a compound of Formula (Ia) wherein A is
4-fluoro-benzo, W is C(R4), R4 is bromo, X is O, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3,4-difluoro-phenyl; [0779] a compound of Formula (Ia) wherein A is
(2,3-b)pyridin-2-yl, W is C(R4), R4 is bromo, X is S, R1
is isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2,
and B is 3,4-difluoro-phenyl; [0780] a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is O, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3,4-difluoro-phenyl; [0781] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3-trifluoromethyl-phenyl; [0782] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is O, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; [0783] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is chloro, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3-chloro-5-fluoro-phenyl; [0784] a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 2-fluoro-4-trifluoromethyl-phenyl; [0785] a compound of Formula (Ia)
wherein A is 4-fluoro-benzo, W is C(R4), R4 is bromo, X is S,
R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B
is 3-trifluoromethyl-4-fluoro-phenyl; [0786] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
4-difluoromethoxy-phenyl; [0787] a compound of Formula (Ia) wherein A is
4-fluoro-benzo, W is C(R4), R4 is methyl, X is O, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3,4-difluoro-phenyl; [0788] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 2-trifluoromethyl-4-fluoro-phenyl; [0789] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is chloro, X is S, R1
is isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2,
and B is 3-trifluoromethoxy-phenyl; [0790] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
ethoxy, R

2 is ethoxy, R3 is H, L is CH2, and B is
2-fluoro-3-trifluoromethyl-phenyl; [0791] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3-trifluoromethyl-4-methoxy-phenyl; [0792] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3-fluoro-5-trifluoromethyl-phenyl; [0793] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is chloro, X is S, R1
is isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2,
and B is 4-methylthio-phenyl; [0794] a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is chloro, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3-chloro-4-trifluoromethoxy-phenyl; [0795] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is chloro, X is S, R1
is isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2,
and B is 3-trifluoromethylthio-phenyl; [0796] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3-fluoro-4-trifluoromethyl-phenyl; [0797] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3,5-difluoro-phenyl; [0798] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3-fluoro-4-methoxy-phenyl; [0799] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3-chloro-4-trifluoromethoxy-phenyl; [0800] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
2,3,5,6-tetrafluoro-4-methoxy-phenyl; [0801] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
4-chloro-3-trifluoromethyl-phenyl; [0802] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 2-fluoro-3-chloro-5-trifluoromethyl-phenyl; [0803] a compound of
Formula (Ia) wherein A is benzo, W is C(R4), R4 is chloro, X is
S, R1 is isopropyloxy, R2 is isopropyloxy, R3 is H, L is
CH2, and B is 4-trifluoromethoxy-phenyl; [0804] a compound of
Formula (Ia) wherein A is benzo, W is C(R4), R4 is bromo, X is
S, R1 is isopropyloxy, R2 is isopropyloxy, R3 is H, L is
CH2, and B is 2-fluoro-4-chloro-5-hydroxy-phenyl; [0805] a compound
of Formula (Ia) wherein A is benzo, W is C(R4), R4 is chloro, X
is S, R1 is isopropyloxy, R2 is isopropyloxy, R3 is H, L
is CH2, and B is 3-trifluoromethyl-4-fluoro-phenyl; [0806] a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
bromo, X is S, R1 is isopropyloxy, R2 is isopropyloxy, R3
is H, L is CH2, and B is 4-chloro-phenyl; [0807] a compound of
Formula (Ia) wherein A is benzo, W is C(R4), R4 is chloro, X is
S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and
B is 3-fluoro-4-chloro-phenyl; [0808] a compound of Formula (Ia) wherein
A is benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
4-trifluoromethylsulfonyl-phenyl; [0809] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is chloro, X is S, R1
is isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2,
and B is 4-fluoro-phenyl; [0810] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
2-fluoro-3-chloro-phenyl; [0811] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is chloro, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is phenyl; [0812] a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is chloro, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 5-chloro-2-fluoro-phenyl;
[0813] a compound of Formula (Ia) wherein A is benzo, W is C(R4),
R4 is bromo, X is S, R1 is n-butyloxy, R2 is n-butyloxy,
R3 is H, L is CH2, and B is 3,4-difluoro-phenyl; [0814] a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
chloro, X is S, R1 is isopropyloxy, R2 is isopropyloxy, R3
is H, L is CH2, and B is 2-fluoro-3-chloro-phenyl; [0815] a compound
of Formula (Ia) wherein A is benzo, W is C(R4), R4 is chloro, X
is S, R1 is isopropyloxy, R2 is isopropyloxy, R3 is H, L
is CH2, and B is 4-trifluoromethyl-phenyl; [0816] a compound of
Formula (Ia) wherein A is benzo, W is C(R4), R4 is chloro, X is
S, R1 is isopropyloxy, R2 is isopropyloxy, R3 is H, L is
CH2, and B is 3-trifluoromethyl-phenyl; [0817] a compound of Formula
(Ia) wherein A is benzo, W is C(R4), R4 is bromo, X is S,
R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B
is 3,5-di-trifluoromethyl-phenyl; [0818] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is chloro, X is S, R1
is isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2,
and B is 3-bromo-phenyl; [0819] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is chloro, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3-chloro-phenyl; [0820] a compound of Formula (Ia) wherein A is benzo,
W is C(R4), R4 is chloro, X is S, R1 is isopropyloxy,
R2 is isopropyloxy, R3 is H, L is CH2, and B is
2-fluoro-3-trifluoromethyl-phenyl; [0821] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
2-trifluoromethyl-phenyl; [0822] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is chloro, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 4-chloro-3-fluoro-phenyl; [0823] a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is chloro, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is 4-fluoro-phenyl;
[0824] a compound of Formula (Ia) wherein A is benzo, W is C(R4),
R4 is chloro, X is S, R1 is isopropyloxy, R2 is
isopropyloxy, R3 is H, L is CH2, and B is
2-trifluoromethyl-4-fluoro-phenyl; [0825] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is phenyl, X is S, R1
is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; [0826] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
2-fluoro-4-chloro-5-methoxy-phenyl; [0827] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3-methoxycarbonyl-phenyl; [0828] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is 2-hydroxy-phenyl, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; [0829] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is chloro, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
4-fluoro-3-trifluoromethyl-phenyl; [0830] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 4-methoxy-3-trifluoromethyl-phenyl; [0831] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 2-fluoro-4-chloro-5-methoxy-phenyl; [0832] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3-cyano-phenyl; [0833] a compound of Formula (Ia) wherein A is benzo, W
is C(R4), R4 is chloro, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is
4-trifluoromethylsulfonyl-phenyl; [0834] enantiomer B, a compound of
Formula (Ia) wherein A is benzo, W is C(R4), R4 is bromo, X is
S, R1 is isopropyloxy, R2 is isopropyloxy, R3 is H, L is
CH2, and B is 3-trifluoromethyl-4-fluoro-phenyl; [0835] a compound
of Formula (Ia) wherein A is benzo, W is C(R4), R4 is bromo, X
is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2,
and B is 4-cyano-phenyl; [0836] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is chloro, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3-fluoro-4-trifluoromethyl-phenyl; [0837] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
2-fluoro-4-trifluoromethyl-phenyl; [0838] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
s-butyl, R2 is s-butyl, R3 is H, L is OCH2, and B is
3,4-difluoro-phenyl; [0839] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is
3-methyl-butoxy, R2 is 3-methyl-butoxy, R3 is H, L is CH2,
and B is 3,4-difluoro-phenyl; [0840] a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is chloro, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3-trifluoromethyl-4-chloro-phenyl; [0841] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is chloro, X is S, R1
is isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2,
and B is 3-fluoro-5-trifluoromethyl-phenyl; [0842] a compound of Formula
(Ia) wherein A is 4-fluoro-benzo, W is C(R4), R4 is bromo, X is
O, R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and
B is 3,4-difluoro-phenyl; [0843] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
2-fluoro-5-trifluoromethyl-phenyl; [0844] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3-fluoro-4-chloro-phenyl; [0845] a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3-trimethylthio-phenyl; [0846] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is thien-3-yl, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; [0847] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is chloro, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is 3-bromo-phenyl;
[0848] a compound of Formula (Ia) wherein A is benzo, W is C(R4),
R4 is chloro, X is S, R1 is ethoxy, R2 is ethoxy, R3
is H, L is CH2, and B is 3-chloro-4-trifluoromethoxy-phenyl; [0849]
a compound of Formula (Ia) wherein A is benzo, W is C(R4), R4
is chloro, X is S, R1 is isopropyloxy, R2 is isopropyloxy,
R3 is H, L is CH2, and B is 2-fluoro-5-trifluoromethyl-phenyl;
[0850] a compound of Formula (Ia) wherein A is benzo, W is C(R4),
R4 is bromo, X is S, R1 is isopropyloxy, R2 is
isopropyloxy, R3 is absent, L is ═CH-- taken to form an alkene
with the phosphorus-bearing adjacent atom, and B is 3,4-difluoro-phenyl;
[0851] a compound of Formula (Ia) wherein A is benzo, W is C(R4),
R4 is chloro, X is S, R1 is isopropyloxy, R2 is
isopropyloxy, R3 is H, L is CH2, and B is 4-chloro-phenyl;
[0852] a compound of Formula (Ia) wherein A is benzo, W is C(R4),
R4 is chloro, X is S, R1 is ethoxy, R2 is ethoxy, R3
is H, L is CH2, and B is 3-chloro-2-fluoro-phenyl; [0853] a compound
of Formula (Ia) wherein A is benzo, W is C(R4), R4 is chloro, X
is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2,
and B is 3-chloro-5-fluoro-phenyl; [0854] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is chloro, X is S, R1
is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3-chloro-phenyl; [0855] a compound of Formula (Ia) wherein A is benzo, W
is C(R4), R4 is chloro, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is
3-fluoro-4-trifluoromethyl-phenyl; [0856] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is chloro, X is S, R1
is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
4-trifluoromethoxy-phenyl; [0857] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is chloro, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
4-fluoro-3-trifluoromethyl-phenyl; [0858] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
methoxycarbonyl-methoxy, R2 is methoxycarbonyl-methoxy, R3 is
H, L is CH2, and B is 3,4-difluoro-phenyl; [0859] a compound of
Formula (Ia) wherein A is benzo, W is C(R4), R4 is bromo, X is
S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and
B is 3-trifluoromethoxy-phenyl; [0860] a compound of Formula (Ia) wherein
A is benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
2-chloro-3-trifluoromethyl-phenyl; [0861] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
4-methylthio-phenyl; [0862] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is chloro, X is S, R1

is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3-fluoro-4-chloro-phenyl; [0863] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
2-fluoro-4-chloro-5-hydroxy-phenyl; [0864] enantiomer A, a compound of
Formula (Ia) wherein A is benzo, W is C(R4), R4 is bromo, X is
S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and
B is 4-trifluoromethoxy-phenyl; [0865] a compound of Formula (Ia) wherein
A is benzo, W is C(R4), R4 is chloro, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
4-chloro-3-trifluoromethyl-phenyl; [0866] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
2-trifluoromethyl-4-fluoro-phenyl; [0867] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
2-chloro-phenyl; [0868] a compound of Formula (Ia) wherein A is benzo, W
is C(R4), R4 is chloro, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is
4-trifluoromethylthio-phenyl; [0869] a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is chloro, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 2-fluoro-4-trifluoromethyl-phenyl; [0870] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is chloro, X is S, R1
is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
4-trifluoromethyl-phenyl; [0871] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is 2-fluoro-phenyl, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; [0872] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is chloro, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
2-fluoro-5-trifluoromethyl-phenyl; [0873] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
2,3,5,6-tetrafluoro-4-hydroxy-phenyl; [0874] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is chloro, X is S, R1
is isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2,
and B is 3-trifluoromethyl-4-methoxy-phenyl; [0875] a compound of Formula
(Ia) wherein A is benzo, W is C(R4), R4 is chloro, X is S,
R1 is isopropyloxy, R2 is isopropyloxy, R3 is H, L is
CH2, and B is 2,6-dichloro-phenyl; [0876] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is chloro, X is S, R1
is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
2-fluoro-3-trifluoromethyl-phenyl; [0877] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
methoxy, R2 is methoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; [0878] a compound of Formula (Ia) wherein A is
3-trifluoromethyl-4-fluoro-benzo, W is C(R4), R4 is bromo, X is
N(methanesulfonyl), R1 is isopropyloxy, R2 is isopropyloxy,
R3 is H, L is CH2, and B is 4-fluoro-3-trifluoromethyl-phenyl;
[0879] a compound of Formula (Ia) wherein A is benzo, W is C(R4),
R4 is chloro, X is S, R1 is ethoxy, R2 is ethoxy, R3
is H, L is CH2, and B is 3-trifluoromethylthio-phenyl; [0880] a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
chloro, X is S, R1 is isopropyloxy, R2 is isopropyloxy, R3
is H, L is CH2, and B is 2-chloro-3-trifluoromethyl-phenyl; [0881] a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
chloro, X is S, R1 is isopropyloxy, R2 is isopropyloxy, R3
is H, L is CH2, and B is 2-trifluoromethyl-phenyl; [0882] a compound
of Formula (Ia) wherein A is benzo, W is C(R4), R4 is chloro, X
is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2,
and B is 4-methylthio-phenyl; [0883] a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is 3-fluoro-phenyl, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; [0884] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is N(methylcarbonyl), R1
is isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2,
and B is 4-fluoro-3-trifluoromethyl-phenyl; [0885] a compound of Formula
(Ia) wherein A is benzo, W is C(R4), R4 is bromo, X is S,
R1 is isopropyloxy, R2 is isopropyloxy, R3 is H, L is
CH2, and B is 2,3,5,6-tetrafluoro-4-hydroxy-phenyl; [0886] a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
chloro, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is
CH2, and B is 2-fluoro-4-trifluoromethyl-phenyl; [0887] a compound
of Formula (Ia) wherein A is benzo, W is C(R4), R4 is chloro, X
is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2,
and B is 4-chloro-phenyl; [0888] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 2-fluoro-5-trifluoromethyl-phenyl; [0889] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 4-trifluoromethyl-phenyl; [0890] a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is chloro, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3-fluoro-5-trifluoromethyl-phenyl; [0891] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is chloro, X is S, R1
is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
2-chloro-phenyl; [0892] a compound of Formula (Ia) wherein A is benzo, W
is C(R4), R4 is bromo, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is
2-chloro-5-trifluoromethyl-phenyl; [0893] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is H, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is absent, L is ═CH--
taken to form an alkene with the phosphorus-bearing adjacent atom, and B
is 3,4-difluoro-phenyl; [0894] a compound of Formula (Ia) wherein A is
3-trifluoromethyl-4-fluoro-benzo, W is C(R4), R4 is bromo, X is
N(n-propyl), R1 is isopropyloxy, R2 is isopropyloxy, R3 is
H, L is CH2, and B is 4-fluoro-3-trifluoromethyl-phenyl; [0895] a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
bromo, X is N(methyl), R1 is isopropyloxy, R2 is isopropyloxy,
R3 is H, L is CH2, and B is 4-fluoro-3-trifluoromethyl-phenyl;
[0896] a compound of Formula (Ia) wherein A is benzo, W is C(R4),
R4 is bromo, X is S, R1 is 2-acetoxy-ethoxy, R2 is
2-acetoxy-ethoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; [0897] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is chloro, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3-trifluoromethoxy-phenyl; [0898] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is 4-fluoro-phenyl, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; [0899] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is 3-amino-phenyl;
[0900] a compound of Formula (Ia) wherein A is benzo, W is C(R4),
R4 is chloro, X is S, R1 is ethoxy, R2 is ethoxy, R3
is H, L is CH2, and B is 4-methoxy-3-trifluoromethyl-phenyl; [0901]
a compound of Formula (Ia) wherein A is benzo, W is C(R4), R4
is chloro, X is S, R1 is isopropyloxy, R2 is isopropyloxy,
R3 is H, L is CH2, and B is 3,5-di-trifluoromethyl-phenyl;
[0902] enantiomer B, a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is bromo, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 4-fluoro-phenyl; [0903] a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
chloro, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is
CH2, and B is 2-chloro-3-trifluoromethyl-phenyl; [0904] a compound
of Formula (Ia) wherein A is benzo, W is C(R4), R4 is chloro, X
is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2,
and B is 3,5-di-trifluoromethyl-phenyl; [0905] enantiomer B, a compound
of Formula (Ia) wherein A is benzo, W is C(R4), R4 is bromo, X
is S, R1 is isopropyloxy, R2 is isopropyloxy, R3 is H, L
is CH2, and B is 3,4-difluoro-phenyl; [0906] a compound of Formula
(Ia) wherein A is benzo, W is C(R4), R4 is chloro, X is S,
R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B
is 2-trifluoromethyl-phenyl; [0907] a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is chloro, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
2-chloro-5-trifluoromethyl-phenyl; [0908] enantiomer B, a compound of
Formula (Ia) wherein A is benzo, W is C(R4), R4 is bromo, X is
S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and
B is 4-trifluoromethoxy-phenyl; [0909] a compound of Formula (Ia) wherein
A is benzo, W is C(R4), R4 is chloro, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 2-chloro-5-trifluoromethyl-phenyl; [0910] a compound of Formula (Ia)
wherein A is 4-bromo-benzo, W is C(R4), R4 is bromo, X is S,
R1 is isopropyloxy, R2 is isopropyloxy, R3 is H, L is
CH2, and B is 2-fluoro-phenyl; [0911] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is H, X is O, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; [0912] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is s-butyl,
R2 is s-butyl, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; and [0913] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is 3-aminocarbonyl-phenyl, X is S,
R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B
is 3,4-difluoro-phenyl.

[0914] Further embodiments of the present invention are directed to a
compound of Formula (Ia)

##STR00020##

selected from the group consisting of [0915] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is methyl, X is S, R1
is isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2,
and B is 3,4-difluoro-phenyl; [0916] a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is i-propyl, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; [0917] a compound of Formula (Ia) wherein A is
4-fluoro-benzo, W is C(R4), R4 is methyl, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; [0918] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is methyl, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is 3-chloro-phenyl;
[0919] a compound of Formula (Ia) wherein A is benzo, W is C(R4),
R4 is cyclopentyl, X is S, R1 is ethoxy, R2 is ethoxy,
R3 is H, L is CH2, and B is 3,4-difluoro-phenyl; [0920] a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
methyl, X is S, R1 is ethoxy, R2 is isobutyl, R3 is H, L
is CH2, and B is 3,4-difluoro-phenyl; [0921] a compound of Formula
(Ia) wherein A is benzo, W is C(R4), R4 is methyl, X is S,
R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B
is 3-fluoro-phenyl; [0922] a compound of Formula (Ia) wherein A is
7-fluoro-benzo, W is C(R4), R4 is methyl, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; [0923] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is methyl, X is O, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; [0924] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is methyl, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
2,3-difluoro-phenyl; [0925] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is methyl, X is O, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3,4-difluoro-phenyl; [0926] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is chloro, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3,4-difluoro-phenyl; [0927] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is methyl, X is S, R1 is isobutyl,
R2 is isobutyl, R3 is H, L is OCH2, and B is
3,4-difluoro-phenyl; [0928] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is methyl, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; [0929] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3,4-difluoro-phenyl; [0930] a compound of Formula (Ia) wherein A is
6-fluoro-benzo, W is C(R4), R4 is methyl, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; [0931] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is methyl, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3,5-difluoro-phenyl; [0932] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is methyl, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is 3-methyl-phenyl;
[0933] a compound of Formula (Ia) wherein A is benzo, W is C(R4),
R4 is i-propyl, X is S, R1 is isopropyloxy, R2 is
isopropyloxy, R3 is H, L is CH2, and B is 3,4-difluoro-phenyl;
[0934] a compound of Formula (Ia) wherein A is benzo, W is C(R4),
R4 is cyclopropyl, X is S, R1 is isopropyloxy, R2 is
isopropyloxy, R3 is H, L is CH2, and B is 3,4-difluoro-phenyl;
[0935] a compound of Formula (Ia) wherein A is benzo, W is C(R4),
R4 is methyl, X is S, R1 is ethoxy, R2 is ethoxy, R3
is H, L is CH2, and B is 3,4-dichloro-phenyl; [0936] a compound of
Formula (Ia) wherein A is benzo, W is C(R4), R4 is methyl, X is
S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and
B is 2-fluoro-phenyl; [0937] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is methyl, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
2-fluoro-3-chloro-phenyl; [0938] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-dichloro-phenyl; [0939] a compound of Formula (Ia) wherein A is
benzo, W is N, X is S, R1 is isopropyloxy, R2 is isopropyloxy,
R3 is H, L is CH2, and B is 3,4-difluoro-phenyl; [0940] a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
methyl, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is
CH2, and B is 2-methyl-phenyl; [0941] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is methyl, X is S, R1
is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
2-chloro-4-fluoro-phenyl; [0942] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is methyl, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
2-chloro-3,5-difluoro-phenyl; [0943] a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is cyclopropyl, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; [0944] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is methyl, X is S, R1 is ethoxy,
R2 is methyl, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; [0945] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is methyl, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3-trifluoromethyl-4-fluoro-phenyl; [0946] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is methyl, X is S, R1
is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3-methoxy-phenyl; [0947] a compound of Formula (Ia) wherein A is benzo, W
is C(R4), R4 is methyl, X is S, R1 is isobutyl, R2 is
isobutyl, R3 is H, L is CH2, and B is 3,4-difluoro-phenyl;
[0948] a compound of Formula (Ia) wherein A is (2,3-b)pyridin-2-yl, W is
C(R4), R4 is methyl, X is S, R1 is isopropyloxy, R2
is isopropyloxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; [0949] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is methyl, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
2,3-dichloro-phenyl; [0950] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is methyl, X is S, R1 is ethoxy,
R2 is isobutyl, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; [0951] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is methyl, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
2-fluoro-3-trifluoromethyl-phenyl; [0952] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is cyclopentyl, X is S,
R1 is isopropyloxy, R2 is isopropyloxy, R3 is H, L is
CH2, and B is 3,4-difluoro-phenyl; [0953] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is H, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3-trifluoromethyl-phenyl; [0954] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is methyl, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is 3-bromo-phenyl;
[0955] a compound of Formula (Ia) wherein A is benzo, W is C(R4),
R4 is cyclobutyl, X is S, R1 is ethoxy, R2 is ethoxy,
R3 is H, L is CH2, and B is 3,4-difluoro-phenyl; [0956] a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
methyl, X is S, R1 is n-propyl, R2 is n-propyl, R3 is H, L
is OCH2, and B is 3,4-difluoro-phenyl; [0957] a compound of Formula
(Ia) wherein A is benzo, W is C(R4), R4 is trifluoromethyl, X
is S, R1 is isopropyloxy, R2 is isopropyloxy, R3 is H, L
is CH2, and B is 3,4-difluoro-phenyl; [0958] a compound of Formula
(Ia) wherein A is benzo, W is C(R4), R4 is methyl, X is S,
R1 is n-propyl, R2 is n-propyl, R3 is H, L is CH2,
and B is 3,4-difluoro-phenyl; [0959] a compound of Formula (Ia) wherein A
is 5-fluoro-benzo, W is C(R4), R4 is methyl, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; [0960] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is methyl, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is naphthalen-2-yl;
[0961] a compound of Formula (Ia) wherein A is benzo, W is C(R4),
R4 is methyl, X is S, R1 is ethoxy, R2 is ethoxy, R3
is H, L is CH2, and B is 2,5-dichloro-phenyl; [0962] a compound of
Formula (Ia) wherein A is benzo, W is C(R4), R4 is methyl, X is
S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and
B is 2-chloro-phenyl; [0963] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is methyl, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3-trifluoromethyl-4-chloro-phenyl; [0964] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is methyl, X is S, R1
is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
4-fluoro-phenyl; [0965] a compound of Formula (Ia) wherein A is benzo, W
is C(R4), R4 is H, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 4-fluoro-phenyl; [0966] a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
methyl, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is
CH2, and B is 3-trifluoromethyl-phenyl; [0967] a compound of Formula
(Ia) wherein A is benzo, W is C(R4), R4 is methyl, X is S,
R1 is 2,2-dimethyl-propyl, R2 is 2,2-dimethyl-propyl, R3
is H, L is CH2, and B is 3,4-difluoro-phenyl; [0968] a compound of
Formula (Ia) wherein A is benzo, W is C(R4), R4 is methyl, X is
S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and
B is 2,6-dichloro-phenyl; [0969] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is methyl, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
4-trifluoromethoxy-phenyl; [0970] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is methyl, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3-fluoro-5-trifluoromethyl-phenyl; [0971] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is methyl, X is S, R1
is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3-trifluoromethoxy-phenyl; [0972] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is H, X is S, R1 is ethoxy, R2
is ethoxy, R3 is H, L is CH2, and B is
3-fluoro-4-trifluoromethyl-phenyl; [0973] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is methyl, X is S, R1
is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
2-trifluoromethyl-phenyl; [0974] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is methyl, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
2-fluoro-3-methyl-6-chloro-phenyl; [0975] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is methyl, X is S, R1
is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
2-trifluoromethoxy-phenyl; [0976] a compound of Formula (Ia) wherein A is
5-methyl-benzo, W is C(R4), R4 is methyl, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3,4-difluoro-phenyl; [0977] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is H, X is S, R1 is isopropyloxy,
R2 is isopropyloxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; [0978] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is phenyl, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-dichloro-phenyl; [0979] a compound of Formula (Ia) wherein A is
4-chloro-benzo, W is C(R4), R4 is methyl, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-dichloro-phenyl; [0980] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is methyl, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is 2-bromo-phenyl;
[0981] a compound of Formula (Ia) wherein A is benzo, W is C(R4),
R4 is methyl, X is S, R1 is ethoxy, R2 is ethoxy, R3
is H, L is CH2, and B is 2-fluoro-5-trifluoromethyl-phenyl; [0982] a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
H, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is
CH2, and B is 4-trifluoromethyl-phenyl; [0983] a compound of Formula
(Ia) wherein A is benzo, W is C(R4), R4 is H, X is S, R1
is isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2,
and B is 3-trifluoromethyl-phenyl; [0984] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is H, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
4-bromo-phenyl; [0985] a compound of Formula (Ia) wherein A is benzo, W
is C(R4), R4 is methyl, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is
5-chloro-benzo[1,3]dioxol-6-yl; [0986] a compound of Formula (Ia) wherein
A is benzo, W is C(R4), R4 is methyl, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3-(pyridin-4-yl)-phenyl; [0987] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is methyl, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
2-fluoro-3-chloro-5-trifluoromethyl-phenyl; [0988] a compound of Formula
(Ia) wherein A is benzo, W is C(R4), R4 is H, X is S, R1
is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
phenyl; [0989] a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is H, X is S, R1 is ethoxy, R2 is ethoxy,
R3 is H, L is CH2, and B is 3,4-difluoro-phenyl;

[0990] a compound of Formula (Ia) wherein A is benzo, W is C(R4),
R4 is methyl, X is S, R1 is ethoxy, R2 is ethoxy, R3
is H, L is CH2, and B is 2,4-dichloro-5-fluoro-phenyl; [0991] a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
methyl, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is
CH2, and B is 3-biphenyl; [0992] a compound of Formula (Ia) wherein
A is benzo, W is C(R4), R4 is H, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-dichloro-phenyl; [0993] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is methyl, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is CH3, L is CH2, and B is
3,4-difluoro-phenyl; [0994] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is H, X is S, R1 is ethoxy, R2
is ethoxy, R3 is H, L is CH2, and B is 2-fluoro-phenyl; [0995]
a compound of Formula (Ia) wherein A is benzo, W is C(R4), R4
is methyl, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L
is CH2, and B is 2-chloro-3-trifluoromethyl-phenyl; [0996] a
compound of Formula (Ia) wherein A is 6-methoxy-benzo, W is C(R4),
R4 is methyl, X is S, R1 is ethoxy, R2 is ethoxy, R3
is H, L is CH2, and B is 3,4-difluoro-phenyl; [0997] a compound of
Formula (Ia) wherein A is benzo, W is C(R4), R4 is H, X is S,
R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B
is naphthalen-2-yl; [0998] a compound of Formula (Ia) wherein A is
4-trifluoromethyl-benzo, W is C(R4), R4 is methyl, X is S,
R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B
is 3,4-difluoro-phenyl; [0999] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is H, X is S, R1 is ethoxy, R2
is ethoxy, R3 is H, L is CH2, and B is 2-chloro-phenyl; [1000]
a compound of Formula (Ia) wherein A is benzo, W is C(R4), R4
is H, X is O, R1 is ethoxy, R2 is ethoxy, R3 is H, L is
CH2, and B is 4-fluoro-phenyl; [1001] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3-methoxy-4-fluoro-phenyl; [1002] a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
2-hydroxy-phenyl; [1003] a compound of Formula (Ia) wherein A is benzo, W
is C(R4), R4 is bromo, X is S, R1 is isopropyloxy, R2
is isopropyloxy, R3 is H, L is CH2, and B is
3-trifluoromethyl-4-fluoro-phenyl; [1004] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3-hydroxy-phenyl; [1005] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 2-fluoro-3-hydroxy-phenyl; [1006] a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 5-chloro-2-fluoro-phenyl; [1007] a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3-methoxy-4-fluoro-phenyl; [1008] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3-chloro-phenyl; [1009] a compound of Formula (Ia) wherein A is benzo,
W is C(R4), R4 is bromo, X is S, R1 is isopropyloxy,
R2 is isopropyloxy, R3 is H, L is CH2, and B is
2,3,5,6-tetrafluoro-4-methoxy-phenyl; [1010] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 2-fluoro-4-methoxy-phenyl; [1011] a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3-chloro-4-fluoro-phenyl; [1012] a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 4-trifluoromethylsulfonyl-phenyl; [1013] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3-methoxy-phenyl; [1014] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is 4-chloro-phenyl;
[1015] a compound of Formula (Ia) wherein A is benzo, W is C(R4),
R4 is bromo, X is S, R1 is ethoxy, R2 is ethoxy, R3
is H, L is CH2, and B is 3-chloro-5-fluoro-phenyl; [1016] a compound
of Formula (Ia) wherein A is benzo, W is C(R4), R4 is bromo, X
is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2,
and B is 3,5-dimethoxy-phenyl; [1017] a compound of Formula (Ia) wherein
A is benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
5-chloro-2-fluoro-phenyl; [1018] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3-hydroxy-4-fluoro-phenyl; [1019] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3-chloro-4-fluoro-phenyl; [1020] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
4-trifluoromethyl-phenyl; [1021] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
2-methoxy-phenyl; [1022] a compound of Formula (Ia) wherein A is benzo, W
is C(R4), R4 is chloro, X is S, R1 is isopropyloxy,
R2 is isopropyloxy, R3 is H, L is CH2, and B is
4-trifluoromethylthio-phenyl; [1023] a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is chloro, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 4-trifluoromethylsulfonyl-phenyl; [1024] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3,4-difluoro-phenyl; [1025] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3-methoxy-phenyl; [1026] a compound of Formula (Ia) wherein A is benzo, W
is C(R4), R4 is bromo, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 3-bromo-phenyl; [1027] a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
chloro, X is S, R1 is isopropyloxy, R2 is isopropyloxy, R3
is H, L is CH2, and B is 2-fluoro-4-trifluoromethyl-phenyl; [1028] a
compound of Formula (Ia) wherein A is 4-fluoro-benzo, W is C(R4),
R4 is bromo, X is S, R1 is isopropyloxy, R2 is
isopropyloxy, R3 is H, L is CH2, and B is 3,4-difluoro-phenyl;
[1029] a compound of Formula (Ia) wherein A is benzo, W is C(R4),
R4 is bromo, X is S, R1 is ethoxy, R2 is ethoxy, R3
is H, L is CH2, and B is 3-hydroxy-phenyl; [1030] a compound of
Formula (Ia) wherein A is benzo, W is C(R4), R4 is bromo, X is
S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and
B is 2-fluoro-3-methoxy-phenyl; [1031] a compound of Formula (Ia) wherein
A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3-fluoro-4-chloro-phenyl; [1032] a compound of Formula (Ia) wherein A
is 4-fluoro-benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3-trifluoromethyl-4-fluoro-phenyl; [1033] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is chloro, X is S, R1
is isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2,
and B is 3-chloro-4-fluoro-phenyl; [1034] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 2-chloro-3-trifluoromethyl-phenyl; [1035] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3-fluoro-4-methoxy-phenyl; [1036] a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is 4-fluoro-phenyl;
[1037] a compound of Formula (Ia) wherein A is benzo, W is C(R4),
R4 is bromo, X is S, R1 is isopropyloxy, R2 is
isopropyloxy, R3 is H, L is CH2, and B is
3-trifluoromethyl-4-fluoro-phenyl; [1038] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3-fluoro-phenyl; [1039] a compound of Formula (Ia) wherein A is benzo,
W is C(R4), R4 is chloro, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 3-chloro-4-fluoro-phenyl;
[1040] a compound of Formula (Ia) wherein A is benzo, W is C(R4),
R4 is bromo, X is S, R1 is isopropyloxy, R2 is
isopropyloxy, R3 is H, L is CH2, and B is 2,3-difluoro-phenyl;
[1041] a compound of Formula (Ia) wherein A is benzo, W is C(R4),
R4 is bromo, X is S, R1 is ethoxy, R2 is ethoxy, R3
is H, L is CH2, and B is 3-nitro-phenyl; [1042] a compound of
Formula (Ia) wherein A is benzo, W is C(R4), R4 is bromo, X is
S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and
B is 3-pyrrol-1-yl-phenyl; [1043] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
4-methoxy-phenyl; [1044] a compound of Formula (Ia) wherein A is benzo, W
is C(R4), R4 is bromo, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is
4-trifluoromethylthio-phenyl; [1045] a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
4-fluoro-3-trimethyl-phenyl; [1046] a compound of Formula (Ia) wherein A
is 4-fluoro-benzo, W is C(R4), R4 is bromo, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; [1047] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is 4-fluoro-phenyl;
[1048] a compound of Formula (Ia) wherein A is benzo, W is C(R4),
R4 is bromo, X is S, R1 is isopropyloxy, R2 is
isopropyloxy, R3 is H, L is CH2, and B is 4-methylthio-phenyl;
[1049] a compound of Formula (Ia) wherein A is benzo, W is C(R4),
R4 is bromo, X is S, R1 is ethoxy, R2 is ethoxy, R3
is H, L is CH2, and B is 3-fluoro-4-chloro-phenyl; [1050] a compound
of Formula (Ia) wherein A is benzo, W is C(R4), R4 is bromo, X
is S, R1 is isopropyloxy, R2 is isopropyloxy, R3 is H, L
is CH2, and B is 4-fluoro-phenyl; [1051] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
4-trifluoromethoxy-phenyl; [1052] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3-chloro-2-fluoro-phenyl; [1053] a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3-trifluoromethylthio-phenyl; [1054] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 2-fluoro-phenyl; [1055] a compound of Formula (Ia) wherein A is benzo,
W is C(R4), R4 is chloro, X is S, R1 is isopropyloxy,
R2 is isopropyloxy, R3 is H, L is CH2, and B is
5-chloro-2-fluoro-phenyl; [1056] a compound of Formula (Ia) wherein A is
4-fluoro-benzo, W is C(R4), R4 is bromo, X is O, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3,4-difluoro-phenyl; [1057] a compound of Formula (Ia) wherein A is
(2,3-b)pyridin-2-yl, W is C(R4), R4 is bromo, X is S, R1
is isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2,
and B is 3,4-difluoro-phenyl; [1058] a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is O, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3,4-difluoro-phenyl; [1059] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3-trifluoromethyl-phenyl; [1060] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is O, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; [1061] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is chloro, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3-chloro-5-fluoro-phenyl; [1062] a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 2-fluoro-4-trifluoromethyl-phenyl; [1063] a compound of Formula (Ia)
wherein A is 4-fluoro-benzo, W is C(R4), R4 is bromo, X is S,
R1 is ethoxy, R

2 is ethoxy, R3 is H, L is CH2, and B is
3-trifluoromethyl-4-fluoro-phenyl; [1064] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
4-difluoromethoxy-phenyl; [1065] a compound of Formula (Ia) wherein A is
4-fluoro-benzo, W is C(R4), R4 is methyl, X is O, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3,4-difluoro-phenyl; [1066] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 2-trifluoromethyl-4-fluoro-phenyl; [1067] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is chloro, X is S, R1
is isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2,
and B is 3-trifluoromethoxy-phenyl; [1068] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
2-fluoro-3-trifluoromethyl-phenyl; [1069] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3-trifluoromethyl-4-methoxy-phenyl; [1070] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3-fluoro-5-trifluoromethyl-phenyl; [1071] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is chloro, X is S, R1
is isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2,
and B is 4-methylthio-phenyl; [1072] a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is chloro, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3-chloro-4-trifluoromethoxy-phenyl; [1073] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is chloro, X is S, R1
is isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2,
and B is 3-trifluoromethylthio-phenyl; [1074] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3-fluoro-4-trifluoromethyl-phenyl; [1075] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3,5-difluoro-phenyl; [1076] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3-fluoro-4-methoxy-phenyl; [1077] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3-chloro-4-trifluoromethoxy-phenyl; [1078] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
2,3,5,6-tetrafluoro-4-methoxy-phenyl; [1079] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
4-chloro-3-trifluoromethyl-phenyl; [1080] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 2-fluoro-3-chloro-5-trifluoromethyl-phenyl; [1081] a compound of
Formula (Ia) wherein A is benzo, W is C(R4), R4 is chloro, X is
S, R1 is isopropyloxy, R2 is isopropyloxy, R3 is H, L is
CH2, and B is 4-trifluoromethoxy-phenyl; [1082] a compound of
Formula (Ia) wherein A is benzo, W is C(R4), R4 is bromo, X is
S, R1 is isopropyloxy, R2 is isopropyloxy, R3 is H, L is
CH2, and B is 2-fluoro-4-chloro-5-hydroxy-phenyl; [1083] a compound
of Formula (Ia) wherein A is benzo, W is C(R4), R4 is chloro, X
is S, R1 is isopropyloxy, R2 is isopropyloxy, R3 is H, L
is CH2, and B is 3-trifluoromethyl-4-fluoro-phenyl; [1084] a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
bromo, X is S, R1 is isopropyloxy, R2 is isopropyloxy, R3
is H, L is CH2, and B is 4-chloro-phenyl; [1085] a compound of
Formula (Ia) wherein A is benzo, W is C(R4), R4 is chloro, X is
S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and
B is 3-fluoro-4-chloro-phenyl; [1086] a compound of Formula (Ia) wherein
A is benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
4-trifluoromethylsulfonyl-phenyl; [1087] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is chloro, X is S, R1
is isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2,
and B is 4-fluoro-phenyl; [1088] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
2-fluoro-3-chloro-phenyl; [1089] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is chloro, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is phenyl; [1090] a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is chloro, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 5-chloro-2-fluoro-phenyl;
[1091] a compound of Formula (Ia) wherein A is benzo, W is C(R4),
R4 is bromo, X is S, R1 is n-butyloxy, R2 is n-butyloxy,
R3 is H, L is CH2, and B is 3,4-difluoro-phenyl; [1092] a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
chloro, X is S, R1 is isopropyloxy, R2 is isopropyloxy, R3
is H, L is CH2, and B is 2-fluoro-3-chloro-phenyl; [1093] a compound
of Formula (Ia) wherein A is benzo, W is C(R4), R4 is chloro, X
is S, R1 is isopropyloxy, R2 is isopropyloxy, R3 is H, L
is CH2, and B is 4-trifluoromethyl-phenyl; [1094] a compound of
Formula (Ia) wherein A is benzo, W is C(R4), R4 is chloro, X is
S, R1 is isopropyloxy, R2 is isopropyloxy, R3 is H, L is
CH2, and B is 3-trifluoromethyl-phenyl; [1095] a compound of Formula
(Ia) wherein A is benzo, W is C(R4), R4 is bromo, X is S,
R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B
is 3,5-di-trifluoromethyl-phenyl; [1096] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is chloro, X is S, R1
is isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2,
and B is 3-bromo-phenyl; [1097] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is chloro, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3-chloro-phenyl; [1098] a compound of Formula (Ia) wherein A is benzo,
W is C(R4), R4 is chloro, X is S, R1 is isopropyloxy,
R2 is isopropyloxy, R3 is H, L is CH2, and B is
2-fluoro-3-trifluoromethyl-phenyl; [1099] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
2-trifluoromethyl-phenyl; [1100] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is chloro, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 4-chloro-3-fluoro-phenyl; [1101] a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is chloro, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is 4-fluoro-phenyl;
[1102] a compound of Formula (Ia) wherein A is benzo, W is C(R4),
R4 is chloro, X is S, R1 is isopropyloxy, R2 is
isopropyloxy, R3 is H, L is CH2, and B is
2-trifluoromethyl-4-fluoro-phenyl; [1103] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is phenyl, X is S, R1
is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; [1104] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
2-fluoro-4-chloro-5-methoxy-phenyl; [1105] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3-methoxycarbonyl-phenyl; [1106] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is 2-hydroxy-phenyl, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; [1107] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is chloro, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
4-fluoro-3-trifluoromethyl-phenyl; [1108] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 4-methoxy-3-trifluoromethyl-phenyl; [1109] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 2-fluoro-4-chloro-5-methoxy-phenyl; [1110] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3-cyano-phenyl; [1111] a compound of Formula (Ia) wherein A is benzo, W
is C(R4), R4 is chloro, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is
4-trifluoromethylsulfonyl-phenyl; [1112] enantiomer B, a compound of
Formula (Ia) wherein A is benzo, W is C(R4), R4 is bromo, X is
S, R1 is isopropyloxy, R2 is isopropyloxy, R3 is H, L is
CH2, and B is 3-trifluoromethyl-4-fluoro-phenyl; [1113] a compound
of Formula (Ia) wherein A is benzo, W is C(R4), R4 is bromo, X
is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2,
and B is 4-cyano-phenyl; [1114] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is chloro, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3-fluoro-4-trifluoromethyl-phenyl; [1115] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
2-fluoro-4-trifluoromethyl-phenyl; [1116] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
s-butyl, R2 is s-butyl, R3 is H, L is OCH2, and B is
3,4-difluoro-phenyl; [1117] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is
3-methyl-butoxy, R2 is 3-methyl-butoxy, R3 is H, L is CH2,
and B is 3,4-difluoro-phenyl; [1118] a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is chloro, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3-trifluoromethyl-4-chloro-phenyl; [1119] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is chloro, X is S, R1
is isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2,
and B is 3-fluoro-5-trifluoromethyl-phenyl; [1120] a compound of Formula
(Ia) wherein A is 4-fluoro-benzo, W is C(R4), R4 is bromo, X is
O, R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and
B is 3,4-difluoro-phenyl; [1121] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
2-fluoro-5-trifluoromethyl-phenyl; [1122] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3-fluoro-4-chloro-phenyl; [1123] a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3-trimethylthio-phenyl; [1124] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is thien-3-yl, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; [1125] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is chloro, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is 3-bromo-phenyl;
[1126] a compound of Formula (Ia) wherein A is benzo, W is C(R4),
R4 is chloro, X is S, R1 is ethoxy, R2 is ethoxy, R3
is H, L is CH2, and B is 3-chloro-4-trifluoromethoxy-phenyl; [1127]
a compound of Formula (Ia) wherein A is benzo, W is C(R4), R4
is chloro, X is S, R1 is isopropyloxy, R2 is isopropyloxy,
R3 is H, L is CH2, and B is 2-fluoro-5-trifluoromethyl-phenyl;
[1128] a compound of Formula (Ia) wherein A is benzo, W is C(R4),
R4 is bromo, X is S, R1 is isopropyloxy, R2 is
isopropyloxy, R3 is absent, L is ═CH-- taken to form an alkene
with the phosphorus-bearing adjacent atom, and B is 3,4-difluoro-phenyl;
[1129] a compound of Formula (Ia) wherein A is benzo, W is C(R4),
R4 is chloro, X is S, R1 is isopropyloxy, R2 is
isopropyloxy, R3 is H, L is CH2, and B is 4-chloro-phenyl;
[1130] a compound of Formula (Ia) wherein A is benzo, W is C(R4),
R4 is chloro, X is S, R1 is ethoxy, R2 is ethoxy, R3
is H, L is CH2, and B is 3-chloro-2-fluoro-phenyl; [1131] a compound
of Formula (Ia) wherein A is benzo, W is C(R4), R4 is chloro, X
is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2,
and B is 3-chloro-5-fluoro-phenyl; [1132] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is chloro, X is S, R1
is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3-chloro-phenyl; [1133] a compound of Formula (Ia) wherein A is benzo, W
is C(R4), R4 is chloro, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is
3-fluoro-4-trifluoromethyl-phenyl; [1134] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is chloro, X is S, R1
is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
4-trifluoromethoxy-phenyl; [1135] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is chloro, X is S, R

1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
4-fluoro-3-trifluoromethyl-phenyl; [1136] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
methoxycarbonyl-methoxy, R2 is methoxycarbonyl-methoxy, R3 is
H, L is CH2, and B is 3,4-difluoro-phenyl; [1137] a compound of
Formula (Ia) wherein A is benzo, W is C(R4), R4 is bromo, X is
S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and
B is 3-trifluoromethoxy-phenyl; [1138] a compound of Formula (Ia) wherein
A is benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
2-chloro-3-trifluoromethyl-phenyl; [1139] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
4-methylthio-phenyl; [1140] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is chloro, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3-fluoro-4-chloro-phenyl; [1141] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
2-fluoro-4-chloro-5-hydroxy-phenyl; [1142] enantiomer A, a compound of
Formula (Ia) wherein A is benzo, W is C(R4), R4 is bromo, X is
S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and
B is 4-trifluoromethoxy-phenyl; [1143] a compound of Formula (Ia) wherein
A is benzo, W is C(R4), R4 is chloro, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
4-chloro-3-trifluoromethyl-phenyl; [1144] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
2-trifluoromethyl-4-fluoro-phenyl; [1145] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
2-chloro-phenyl; [1146] a compound of Formula (Ia) wherein A is benzo, W
is C(R4), R4 is chloro, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is
4-trifluoromethylthio-phenyl; [1147] a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is chloro, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 2-fluoro-4-trifluoromethyl-phenyl; [1148] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is chloro, X is S, R1
is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
4-trifluoromethyl-phenyl; [1149] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is 2-fluoro-phenyl, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; [1150] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is chloro, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
2-fluoro-5-trifluoromethyl-phenyl; [1151] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
2,3,5,6-tetrafluoro-4-hydroxy-phenyl; [1152] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is chloro, X is S, R1
is isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2,
and B is 3-trifluoromethyl-4-methoxy-phenyl; [1153] a compound of Formula
(Ia) wherein A is benzo, W is C(R4), R4 is chloro, X is S,
R1 is isopropyloxy, R2 is isopropyloxy, R3 is H, L is
CH2, and B is 2,6-dichloro-phenyl; [1154] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is chloro, X is S, R1
is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
2-fluoro-3-trifluoromethyl-phenyl; [1155] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
methoxy, R2 is methoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; [1156] a compound of Formula (Ia) wherein A is
3-trifluoromethyl-4-fluoro-benzo, W is C(R4), R4 is bromo, X is
N(methanesulfonyl), R1 is isopropyloxy, R2 is isopropyloxy,
R3 is H, L is CH2, and B is 4-fluoro-3-trifluoromethyl-phenyl;
[1157] a compound of Formula (Ia) wherein A is benzo, W is C(R4),
R4 is chloro, X is S, R1 is ethoxy, R2 is ethoxy, R3
is H, L is CH2, and B is 3-trifluoromethylthio-phenyl; [1158] a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
chloro, X is S, R1 is isopropyloxy, R2 is isopropyloxy, R3
is H, L is CH2, and B is 2-chloro-3-trifluoromethyl-phenyl; [1159] a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
chloro, X is S, R1 is isopropyloxy, R2 is isopropyloxy, R3
is H, L is CH2, and B is 2-trifluoromethyl-phenyl; [1160] a compound
of Formula (Ia) wherein A is benzo, W is C(R4), R4 is chloro, X
is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2,
and B is 4-methylthio-phenyl; [1161] a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is 3-fluoro-phenyl, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; [1162] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is N(methylcarbonyl), R1
is isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2,
and B is 4-fluoro-3-trifluoromethyl-phenyl; [1163] a compound of Formula
(Ia) wherein A is benzo, W is C(R4), R4 is bromo, X is S,
R1 is isopropyloxy, R2 is isopropyloxy, R3 is H, L is
CH2, and B is 2,3,5,6-tetrafluoro-4-hydroxy-phenyl; [1164] a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
chloro, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is
CH2, and B is 2-fluoro-4-trifluoromethyl-phenyl; [1165] a compound
of Formula (Ia) wherein A is benzo, W is C(R4), R4 is chloro, X
is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2,
and B is 4-chloro-phenyl; [1166] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 2-fluoro-5-trifluoromethyl-phenyl; [1167] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 4-trifluoromethyl-phenyl; and [1168] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is chloro, X is S, R1
is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3-fluoro-5-trifluoromethyl-phenyl.

[1169] A further embodiment of the present invention is directed to a
compound of Formula (Ia)

##STR00021##

selected from the group consisting of [1170] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is methyl, X is S, R1
is isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2,
and B is 3,4-difluoro-phenyl; [1171] a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is i-propyl, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; [1172] a compound of Formula (Ia) wherein A is
4-fluoro-benzo, W is C(R4), R4 is methyl, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; [1173] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is methyl, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is 3-chloro-phenyl;
[1174] a compound of Formula (Ia) wherein A is benzo, W is C(R4),
R4 is cyclopentyl, X is S, R1 is ethoxy, R2 is ethoxy,
R3 is H, L is CH2, and B is 3,4-difluoro-phenyl; [1175] a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
methyl, X is S, R1 is ethoxy, R2 is isobutyl, R3 is H, L
is CH2, and B is 3,4-difluoro-phenyl; [1176] a compound of Formula
(Ia) wherein A is benzo, W is C(R4), R4 is methyl, X is S,
R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B
is 3-fluoro-phenyl; [1177] a compound of Formula (Ia) wherein A is
7-fluoro-benzo, W is C(R4), R4 is methyl, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; [1178] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is methyl, X is O, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; [1179] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is methyl, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
2,3-difluoro-phenyl; [1180] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is methyl, X is O, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3,4-difluoro-phenyl; [1181] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is chloro, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3,4-difluoro-phenyl; [1182] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is methyl, X is S, R1 is isobutyl,
R2 is isobutyl, R3 is H, L is OCH2, and B is
3,4-difluoro-phenyl; [1183] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is methyl, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; [1184] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3,4-difluoro-phenyl; [1185] a compound of Formula (Ia) wherein A is
6-fluoro-benzo, W is C(R4), R4 is methyl, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; [1186] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is methyl, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3,5-difluoro-phenyl; [1187] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is methyl, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is 3-methyl-phenyl;
[1188] a compound of Formula (Ia) wherein A is benzo, W is C(R4),
R4 is i-propyl, X is S, R1 is isopropyloxy, R2 is
isopropyloxy, R3 is H, L is CH2, and B is 3,4-difluoro-phenyl;
[1189] a compound of Formula (Ia) wherein A is benzo, W is C(R4),
R4 is cyclopropyl, X is S, R1 is isopropyloxy, R2 is
isopropyloxy, R3 is H, L is CH2, and B is 3,4-difluoro-phenyl;
[1190] a compound of Formula (Ia) wherein A is benzo, W is C(R4),
R4 is methyl, X is S, R1 is ethoxy, R2 is ethoxy, R3
is H, L is CH2, and B is 3,4-dichloro-phenyl; [1191] a compound of
Formula (Ia) wherein A is benzo, W is C(R4), R4 is methyl, X is
S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and
B is 2-fluoro-phenyl; [1192] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is methyl, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
2-fluoro-3-chloro-phenyl; [1193] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-dichloro-phenyl; [1194] a compound of Formula (Ia) wherein A is
benzo, W is N, X is S, R1 is isopropyloxy,

[1195] R2 is isopropyloxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; [1196] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is methyl, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is 2-methyl-phenyl;
[1197] a compound of Formula (Ia) wherein A is benzo, W is C(R4),
R4 is methyl, X is S, R1 is ethoxy, R2 is ethoxy, R3
is H, L is CH2, and B is 2-chloro-4-fluoro-phenyl; [1198] a compound
of Formula (Ia) wherein A is benzo, W is C(R4), R4 is methyl, X
is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2,
and B is 2-chloro-3,5-difluoro-phenyl; [1199] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is cyclopropyl, X is S,
R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B
is 3,4-difluoro-phenyl; [1200] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is methyl, X is S, R1 is ethoxy,
R2 is methyl, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; [1201] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is methyl, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3-trifluoromethyl-4-fluoro-phenyl; [1202] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is methyl, X is S, R1
is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3-methoxy-phenyl; [1203] a compound of Formula (Ia) wherein A is benzo, W
is C(R4), R4 is methyl, X is S, R1 is isobutyl, R2 is
isobutyl, R3 is H, L is CH2, and B is 3,4-difluoro-phenyl;
[1204] a compound of Formula (Ia) wherein A is (2,3-b)pyridin-2-yl, W is
C(R4), R4 is methyl, X is S, R1 is isopropyloxy, R2
is isopropyloxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; [1205] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is methyl, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
2,3-dichloro-phenyl; [1206] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is methyl, X is S, R1 is ethoxy,
R2 is isobutyl, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; [1207] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is methyl, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
2-fluoro-3-trifluoromethyl-phenyl; [1208] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is cyclopentyl, X is S,
R1 is isopropyloxy, R2 is isopropyloxy, R3 is H, L is
CH2, and B is 3,4-difluoro-phenyl; [1209] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is H, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3-trifluoromethyl-phenyl; [1210] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is methyl, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is 3-bromo-phenyl;
[1211] a compound of Formula (Ia) wherein A is benzo, W is C(R4),
R4 is cyclobutyl, X is S, R1 is ethoxy, R2 is ethoxy,
R3 is H, L is CH2, and B is 3,4-difluoro-phenyl; [1212] a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
bromo, X is S, R1 is isopropyloxy, R2 is isopropyloxy, R3
is H, L is CH2, and B is 3-methoxy-4-fluoro-phenyl; [1213] a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
bromo, X is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is
CH2, and B is 2-hydroxy-phenyl; [1214] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3-trifluoromethyl-4-fluoro-phenyl; [1215] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3-hydroxy-phenyl; [1216] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 2-fluoro-3-hydroxy-phenyl; [1217] a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 5-chloro-2-fluoro-phenyl; [1218] a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3-methoxy-4-fluoro-phenyl; [1219] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3-chloro-phenyl; [1220] a compound of Formula (Ia) wherein A is benzo,
W is C(R4), R4 is bromo, X is S, R1 is isopropyloxy,
R2 is isopropyloxy, R3 is H, L is CH2, and B is
2,3,5,6-tetrafluoro-4-methoxy-phenyl; [1221] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 2-fluoro-4-methoxy-phenyl; [1222] a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3-chloro-4-fluoro-phenyl; [1223] a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 4-trifluoromethylsulfonyl-phenyl; [1224] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3-methoxy-phenyl; [1225] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is 4-chloro-phenyl;
[1226] a compound of Formula (Ia) wherein A is benzo, W is C(R4),
R4 is bromo, X is S, R1 is ethoxy, R2 is ethoxy, R3
is H, L is CH2, and B is 3-chloro-5-fluoro-phenyl; [1227] a compound
of Formula (Ia) wherein A is benzo, W is C(R4), R4 is bromo, X
is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2,
and B is 3,5-dimethoxy-phenyl; [1228] a compound of Formula (Ia) wherein
A is benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
5-chloro-2-fluoro-phenyl; [1229] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3-hydroxy-4-fluoro-phenyl; [1230] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3-chloro-4-fluoro-phenyl; [1231] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
4-trifluoromethyl-phenyl; [1232] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
2-methoxy-phenyl; [1233] a compound of Formula (Ia) wherein A is benzo, W
is C(R4), R4 is chloro, X is S, R1 is isopropyloxy,
R2 is isopropyloxy, R3 is H, L is CH2, and B is
4-trifluoromethylthio-phenyl; [1234] a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is chloro, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 4-trifluoromethylsulfonyl-phenyl; [1235] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3,4-difluoro-phenyl; [1236] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3-methoxy-phenyl; [1237] a compound of Formula (Ia) wherein A is benzo, W
is C(R4), R4 is bromo, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 3-bromo-phenyl; [1238] a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
chloro, X is S, R1 is isopropyloxy, R2 is isopropyloxy, R3
is H, L is CH2, and B is 2-fluoro-4-trifluoromethyl-phenyl; [1239] a
compound of Formula (Ia) wherein A is 4-fluoro-benzo, W is C(R4),
R4 is bromo, X is S, R1 is isopropyloxy, R2 is
isopropyloxy, R3 is H, L is CH2, and B is 3,4-difluoro-phenyl;
[1240] a compound of Formula (Ia) wherein A is benzo, W is C(R4),
R4 is bromo, X is S, R1 is ethoxy, R2 is ethoxy, R3
is H, L is CH2, and B is 3-hydroxy-phenyl; [1241] a compound of
Formula (Ia) wherein A is benzo, W is C(R4), R4 is bromo, X is
S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and
B is 2-fluoro-3-methoxy-phenyl; [1242] a compound of Formula (Ia) wherein
A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3-fluoro-4-chloro-phenyl; [1243] a compound of Formula (Ia) wherein A
is 4-fluoro-benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3-trifluoromethyl-4-fluoro-phenyl; [1244] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is chloro, X is S, R1
is isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2,
and B is 3-chloro-4-fluoro-phenyl; [1245] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 2-chloro-3-trifluoromethyl-phenyl; [1246] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3-fluoro-4-methoxy-phenyl; [1247] a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is 4-fluoro-phenyl;
[1248] a compound of Formula (Ia) wherein A is benzo, W is C(R4),
R4 is bromo, X is S, R1 is isopropyloxy, R2 is
isopropyloxy, R3 is H, L is CH2, and B is
3-trifluoromethyl-4-fluoro-phenyl; [1249] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3-fluoro-phenyl; [1250] a compound of Formula (Ia) wherein A is benzo,
W is C(R4), R4 is chloro, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 3-chloro-4-fluoro-phenyl;
[1251] a compound of Formula (Ia) wherein A is benzo, W is C(R4),
R4 is bromo, X is S, R1 is isopropyloxy, R2 is
isopropyloxy, R3 is H, L is CH2, and B is 2,3-difluoro-phenyl;
[1252] a compound of Formula (Ia) wherein A is benzo, W is C(R4),
R4 is bromo, X is S, R1 is ethoxy, R2 is ethoxy, R3
is H, L is CH2, and B is 3-nitro-phenyl; [1253] a compound of
Formula (Ia) wherein A is benzo, W is C(R4), R4 is bromo, X is
S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and
B is 3-pyrrol-1-yl-phenyl; [1254] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
4-methoxy-phenyl; [1255] a compound of Formula (Ia) wherein A is benzo, W
is C(R4), R4 is bromo, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is
4-trifluoromethylthio-phenyl; [1256] a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
4-fluoro-3-trimethyl-phenyl; [1257] a compound of Formula (Ia) wherein A
is 4-fluoro-benzo, W is C(R4), R4 is bromo, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; [1258] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is 4-fluoro-phenyl;
[1259] a compound of Formula (Ia) wherein A is benzo, W is C(R4),
R4 is bromo, X is S, R1 is isopropyloxy, R2 is
isopropyloxy, R3 is H, L is CH2, and B is 4-methylthio-phenyl;
[1260] a compound of Formula (Ia) wherein A is benzo, W is C(R4),
R4 is bromo, X is S, R1 is ethoxy, R2 is ethoxy, R3
is H, L is CH2, and B is 3-fluoro-4-chloro-phenyl; [1261] a compound
of Formula (Ia) wherein A is benzo, W is C(R4), R4 is bromo, X
is S, R1 is isopropyloxy, R2 is isopropyloxy, R3 is H, L
is CH2, and B is 4-fluoro-phenyl; [1262] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
4-trifluoromethoxy-phenyl; [1263] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3-chloro-2-fluoro-phenyl; [1264] a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3-trifluoromethylthio-phenyl; [1265] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 2-fluoro-phenyl; [1266] a compound of Formula (Ia) wherein A is benzo,
W is C(R4), R4 is chloro, X is S, R1 is isopropyloxy,
R2 is isopropyloxy, R3 is H, L is CH2, and B is
5-chloro-2-fluoro-phenyl; [1267] a compound of Formula (Ia) wherein A is
4-fluoro-benzo, W is C(R4), R4 is bromo, X is O, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3,4-difluoro-phenyl; [1268] a compound of Formula (Ia) wherein A is
(2,3-b)pyridin-2-yl, W is C(R4), R4 is bromo, X is S, R1
is isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2,
and B is 3,4-difluoro-phenyl; [1269] a compound of Formula (Ia) wherein A
is benzo, W is C(R

4), R4 is bromo, X is O, R1 is isopropyloxy, R2 is
isopropyloxy, R3 is H, L is CH2, and B is 3,4-difluoro-phenyl;
[1270] a compound of Formula (Ia) wherein A is benzo, W is C(R4),
R4 is bromo, X is S, R1 is ethoxy, R2 is ethoxy, R3
is H, L is CH2, and B is 3-trifluoromethyl-phenyl; [1271] a compound
of Formula (Ia) wherein A is benzo, W is C(R4), R4 is bromo, X
is O, R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2,
and B is 3,4-difluoro-phenyl; [1272] a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is chloro, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3-chloro-5-fluoro-phenyl; [1273] a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 2-fluoro-4-trifluoromethyl-phenyl; [1274] a compound of Formula (Ia)
wherein A is 4-fluoro-benzo, W is C(R4), R4 is bromo, X is S,
R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B
is 3-trifluoromethyl-4-fluoro-phenyl; [1275] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
4-difluoromethoxy-phenyl; [1276] a compound of Formula (Ia) wherein A is
4-fluoro-benzo, W is C(R4), R4 is methyl, X is O, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3,4-difluoro-phenyl; [1277] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 2-trifluoromethyl-4-fluoro-phenyl; [1278] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is chloro, X is S, R1
is isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2,
and B is 3-trifluoromethoxy-phenyl; [1279] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
2-fluoro-3-trifluoromethyl-phenyl; [1280] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3-trifluoromethyl-4-methoxy-phenyl; [1281] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3-fluoro-5-trifluoromethyl-phenyl; [1282] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is chloro, X is S, R1
is isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2,
and B is 4-methylthio-phenyl; [1283] a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is chloro, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3-chloro-4-trifluoromethoxy-phenyl; [1284] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is chloro, X is S, R1
is isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2,
and B is 3-trifluoromethylthio-phenyl; [1285] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3-fluoro-4-trifluoromethyl-phenyl; [1286] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3,5-difluoro-phenyl; [1287] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3-fluoro-4-methoxy-phenyl; [1288] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
3-chloro-4-trifluoromethoxy-phenyl; [1289] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S,

[1290] R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2,
and B is 2,3,5,6-tetrafluoro-4-methoxy-phenyl; [1291] a compound of
Formula (Ia) wherein A is benzo, W is C(R4), R4 is bromo, X is
S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and
B is 4-chloro-3-trifluoromethyl-phenyl; [1292] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 2-fluoro-3-chloro-5-trifluoromethyl-phenyl; [1293] a compound of
Formula (Ia) wherein A is benzo, W is C(R4), R4 is chloro, X is
S, R1 is isopropyloxy, R2 is isopropyloxy, R3 is H, L is
CH2, and B is 4-trifluoromethoxy-phenyl; [1294] a compound of
Formula (Ia) wherein A is benzo, W is C(R4), R4 is bromo, X is
S, R1 is isopropyloxy, R2 is isopropyloxy, R3 is H, L is
CH2, and B is 2-fluoro-4-chloro-5-hydroxy-phenyl; [1295] a compound
of Formula (Ia) wherein A is benzo, W is C(R4), R4 is chloro, X
is S, R1 is isopropyloxy, R2 is isopropyloxy, R3 is H, L
is CH2, and B is 3-trifluoromethyl-4-fluoro-phenyl; [1296] a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
bromo, X is S, R1 is isopropyloxy, R2 is isopropyloxy, R3
is H, L is CH2, and B is 4-chloro-phenyl; [1297] a compound of
Formula (Ia) wherein A is benzo, W is C(R4), R4 is chloro, X is
S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and
B is 3-fluoro-4-chloro-phenyl; [1298] a compound of Formula (Ia) wherein
A is benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
4-trifluoromethylsulfonyl-phenyl; [1299] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is chloro, X is S, R1
is isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2,
and B is 4-fluoro-phenyl; [1300] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
2-fluoro-3-chloro-phenyl; [1301] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is chloro, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is phenyl; [1302] a compound of Formula (Ia) wherein A is benzo, W is
C(R4), R4 is chloro, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 5-chloro-2-fluoro-phenyl;
[1303] a compound of Formula (Ia) wherein A is benzo, W is C(R4),
R4 is bromo, X is S, R1 is n-butyloxy, R2 is n-butyloxy,
R3 is H, L is CH2, and B is 3,4-difluoro-phenyl; [1304] a
compound of Formula (Ia) wherein A is benzo, W is C(R4), R4 is
chloro, X is S, R1 is isopropyloxy, R2 is isopropyloxy, R3
is H, L is CH2, and B is 2-fluoro-3-chloro-phenyl; [1305] a compound
of Formula (Ia) wherein A is benzo, W is C(R4), R4 is chloro, X
is S, R1 is isopropyloxy, R2 is isopropyloxy, R3 is H, L
is CH2, and B is 4-trifluoromethyl-phenyl; [1306] a compound of
Formula (Ia) wherein A is benzo, W is C(R4), R4 is chloro, X is
S, R1 is isopropyloxy, R2 is isopropyloxy, R3 is H, L is
CH2, and B is 3-trifluoromethyl-phenyl; [1307] a compound of Formula
(Ia) wherein A is benzo, W is C(R4), R4 is bromo, X is S,
R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B
is 3,5-di-trifluoromethyl-phenyl; [1308] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is chloro, X is S, R1
is isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2,
and B is 3-bromo-phenyl; [1309] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is chloro, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3-chloro-phenyl; [1310] a compound of Formula (Ia) wherein A is benzo,
W is C(R4), R4 is chloro, X is S, R1 is isopropyloxy,
R2 is isopropyloxy, R3 is H, L is CH2, and B is
2-fluoro-3-trifluoromethyl-phenyl; [1311] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
2-trifluoromethyl-phenyl; [1312] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is chloro, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 4-chloro-3-fluoro-phenyl; [1313] a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is chloro, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is 4-fluoro-phenyl;
[1314] a compound of Formula (Ia) wherein A is benzo, W is C(R4),
R4 is chloro, X is S, R1 is isopropyloxy, R2 is
isopropyloxy, R3 is H, L is CH2, and B is
2-trifluoromethyl-4-fluoro-phenyl; [1315] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is phenyl, X is S, R1
is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; [1316] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
2-fluoro-4-chloro-5-methoxy-phenyl; [1317] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3-methoxycarbonyl-phenyl; [1318] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is 2-hydroxy-phenyl, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3,4-difluoro-phenyl; [1319] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is chloro, X is S, R1 is ethoxy,
R2 is ethoxy, R3 is H, L is CH2, and B is
4-fluoro-3-trifluoromethyl-phenyl; [1320] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 4-methoxy-3-trifluoromethyl-phenyl; [1321] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 2-fluoro-4-chloro-5-methoxy-phenyl; [1322] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
3-cyano-phenyl; [1323] a compound of Formula (Ia) wherein A is benzo, W
is C(R4), R4 is chloro, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is
4-trifluoromethylsulfonyl-phenyl; [1324] enantiomer B, a compound of
Formula (Ia) wherein A is benzo, W is C(R4), R4 is bromo, X is
S, R1 is isopropyloxy, R2 is isopropyloxy, R3 is H, L is
CH2, and B is 3-trifluoromethyl-4-fluoro-phenyl; [1325] a compound
of Formula (Ia) wherein A is benzo, W is C(R4), R4 is bromo, X
is S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2,
and B is 4-cyano-phenyl; [1326] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is chloro, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3-fluoro-4-trifluoromethyl-phenyl; [1327] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
2-fluoro-4-trifluoromethyl-phenyl; [1328] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
s-butyl, R2 is s-butyl, R3 is H, L is OCH2, and B is
3,4-difluoro-phenyl; [1329] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is
3-methyl-butoxy, R2 is 3-methyl-butoxy, R3 is H, L is CH2,
and B is 3,4-difluoro-phenyl; [1330] a compound of Formula (Ia) wherein A
is benzo, W is C(R4), R4 is chloro, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 3-trifluoromethyl-4-chloro-phenyl; [1331] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is chloro, X is S, R1
is isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2,
and B is 3-fluoro-5-trifluoromethyl-phenyl; [1332] a compound of Formula
(Ia) wherein A is 4-fluoro-benzo, W is C(R4), R4 is bromo, X is
O, R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and
B is 3,4-difluoro-phenyl; [1333] a compound of Formula (Ia) wherein A is
benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 2-fluoro-5-trifluoromethyl-phenyl; [1334] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
isopropyloxy, R2 is isopropyloxy, R3 is H, L is CH2, and B
is 4-trifluoromethyl-phenyl; and [1335] a compound of Formula (Ia)
wherein A is benzo, W is C(R4), R4 is bromo, X is S, R1 is
ethoxy, R2 is ethoxy, R3 is H, L is CH2, and B is
2-fluoro-5-trifluoromethyl-phenyl.

[1336] Further embodiments of the present invention are directed to a
compound of Formula (Ib)

##STR00022##

selected from the group consisting of: [1337] a compound of Formula (Ib)
wherein A is benzo, R4 is H, X is S, R1 is ethoxy, R2 is
ethoxy, R3 is H, L is CH2, and B is 2-fluoro-phenyl; [1338] a
compound of Formula (Ib) wherein A is 5-fluoro-benzo, R4 is H, X is
S, R1 is ethoxy, R2 is ethoxy, R3 is H, L is CH2, and
B is 4-fluoro-phenyl; and [1339] a compound of Formula (Ib) wherein A is
5-chloro-benzo, R4 is H, X is N(phenyl), R1 is ethoxy, R2
is ethoxy, R3 is H, L is CH2, and B is 4-fluoro-phenyl.

[1340] For use in medicine, the salts of the compounds of this invention
refer to non-toxic "pharmaceutically acceptable salts." Other salts may,
however, be useful in the preparation of compounds according to this
invention or of their pharmaceutically acceptable salts. Suitable
pharmaceutically acceptable salts of the compounds include acid addition
salts which may, for example, be formed by mixing a solution of the
compound with a solution of a pharmaceutically acceptable acid such as
hydrochloric acid, sulfuric acid, fumaric acid, maleic acid, succinic
acid, acetic acid, benzoic acid, citric acid, tartaric acid, carbonic
acid or phosphoric acid. Furthermore, where the compounds of the
invention carry an acidic moiety, suitable pharmaceutically acceptable
salts thereof may include alkali metal salts, e.g., sodium or potassium
salts; alkaline earth metal salts, e.g., calcium or magnesium salts; and
salts formed with suitable organic ligands, e.g., quaternary ammonium
salts. Thus, representative pharmaceutically acceptable salts include the
following:

[1344] The present invention includes within its scope prodrugs of the
compounds of this invention. In general, such prodrugs will be functional
derivatives of the compounds that are readily convertible in vivo into
the required compound. Thus, in the methods of treatment of the present
invention, the term "administering" shall encompass the treatment of the
various disorders described with the compound specifically disclosed or
with a compound which may not be specifically disclosed, but which
converts to the specified compound in vivo after administration to the
patient. Conventional procedures for the selection and preparation of
suitable prodrug derivatives are described, for example, in "Design of
Prodrugs", ed. H. Bundgaard, Elsevier, 1985.

[1345] Where the compounds according to this invention have at least one
chiral center, they may accordingly exist as enantiomers. Where the
compounds possess two or more chiral centers, they may additionally exist
as diastereomers. It is to be understood that all such isomers and
mixtures thereof are encompassed within the scope of the present
invention. Furthermore, some of the crystalline forms for the compounds
may exist as polymorphs and as such are intended to be included in the
present invention. In addition, some of the compounds may form solvates
with water (i.e., hydrates) or common organic solvents, and such solvates
are also intended to be encompassed within the scope of this invention.

[1346] Where the processes for the preparation of the compounds according
to the invention give rise to mixture of stereoisomers, these isomers may
be separated by conventional techniques such as preparative
chromatography. The compounds may be prepared in racemic form, or
individual enantiomers may be prepared either by enantiospecific
synthesis or by resolution. The compounds may, for example, be resolved
into their component enantiomers by standard techniques, such as the
formation of diastereomeric pairs by salt formation with an optically
active acid, such as (-)-di-p-toluoyl-d-tartaric acid and/or
(+)-di-p-toluoyl-l-tartaric acid followed by fractional crystallization
and regeneration of the free base. The compounds may also be resolved by
formation of diastereomeric esters or amides, followed by chromatographic
separation and removal of the chiral auxiliary. Alternatively, the
compounds may be resolved using a chiral HPLC column.

[1347] One embodiment of the present invention is directed to a
composition comprising the dextrorotatory enantiomer of a compound of
formula (I) wherein said composition is substantially free from the
levorotatory isomer of said compound. In the present context,
substantially free means less than 25%, preferably less than 10%, more
preferably less than 5%, even more preferably less than 2% and even more
preferably less than 1% of the levorotatory isomer calculated as.

[1348] Another embodiment of the present invention is a composition
comprising the levorotatory enantiomer of a compound of formula (I)
wherein said composition is substantially free from the dextrorotatory
isomer of said compound. In the present context, substantially free from
means less than 25%, preferably less than 10%, more preferably less than
5%, even more preferably less than 2% and even more preferably less than
1% of the dextrorotatory isomer calculated as

[1349] During any of the processes for preparation of the compounds of the
present invention, it may be necessary and/or desirable to protect
sensitive or reactive groups on any of the molecules concerned. This may
be achieved by means of conventional protecting groups, such as those
described in Protective Groups in Organic Chemistry, ed. J. F. W. McOmie,
Plenum Press, 1973; and T. W. Greene & P. G. M. Wuts, Protective Groups
in Organic Synthesis, John Wiley & Sons, 1991. The protecting groups may
be removed at a convenient subsequent stage using methods known from the
art.

[1350] Even though the compounds of the present invention (including their
pharmaceutically acceptable salts and pharmaceutically acceptable
solvates) can be administered alone, they will generally be administered
in admixture with a pharmaceutical carrier, excipient or diluent selected
with regard to the intended route of administration and standard
pharmaceutical or veterinary practice. Thus, the present invention is
directed to pharmaceutical and veterinary compositions comprising
compounds of Formula (I) and one or more than one pharmaceutically
acceptable carrier, excipient or diluent.

[1351] By way of example, in the pharmaceutical and veterinary
compositions of the present invention, the compounds of the present
invention may be admixed with any suitable binder(s), lubricant(s),
suspending agent(s), coating agent(s), and/or solubilising agent(s).

[1352] Tablets or capsules of the compounds may be administered singly or
two or more at a time, as appropriate. It is also possible to administer
the compounds in sustained release formulations.

[1353] Alternatively, the compounds of the general Formula (I) can be
administered by inhalation (intratracheal or intranasal) or in the form
of a suppository or pessary, or they may be applied topically in the form
of a lotion, solution, cream, ointment or dusting powder. An alternative
means of transdermal administration is by use of a skin patch. For
example, they can be incorporated into a cream consisting of an aqueous
emulsion of polyethylene glycols or liquid paraffin. They can also be
incorporated, at a concentration of between 1 and 10% by weight, into an
ointment consisting of a white wax or white soft paraffin base together
with such stabilizers and preservatives as may be required.

[1354] For some applications, preferably the compositions are administered
orally in the form of tablets containing excipients such as starch or
lactose, or in capsules or ovules either alone or in admixture with
excipients, or in the form of elixirs, solutions or suspensions
containing flavoring or coloring agents.

[1355] The compositions (as well as the compounds alone) can also be
injected parenterally, for example intracavernosally, intravenously,
intramuscularly, subcutaneously, intradermally or intrathecally. In this
case, the compositions will comprise a suitable carrier or diluent.

[1356] For parenteral administration, the compositions are best used in
the form of a sterile aqueous solution which may contain other
substances, for example, enough salts or monosaccharides to make the
solution isotonic with blood.

[1357] For buccal or sublingual administration, the compositions may be
administered in the form of tablets or lozenges, which can be formulated
in a conventional manner.

[1358] By way of further example, pharmaceutical and veterinary
compositions containing one or more of the compounds of the invention
described herein as the active ingredient can be prepared by intimately
mixing the compound or compounds with a pharmaceutical carrier according
to conventional pharmaceutical compounding techniques. The carrier may
take a wide variety of forms depending upon the desired route of
administration (e.g., oral, parenteral, etc.). Thus for liquid oral
preparations such as suspensions, elixirs and solutions, suitable
carriers and additives include water, glycols, oils, alcohols, flavoring
agents, preservatives, stabilizers, coloring agents and the like; for
solid oral preparations, such as powders, capsules and tablets, suitable
carriers and additives include starches, sugars, diluents, granulating
agents, lubricants, binders, disintegrating agents and the like. Solid
oral preparations also may be coated with substances such as sugars or be
entericly-coated so as to modulate the major site of absorption. For
parenteral administration, the carrier will usually consist of sterile
water, and other ingredients may be added to increase solubility or
preservation. Injectable suspensions or solutions may also be prepared
utilizing aqueous carriers along with appropriate additives.

[1359] Advantageously, compounds of the present invention may be
administered in a single daily dose, or the total daily dosage may be
administered in divided doses of two, three or four times daily.
Furthermore, compounds for the present invention can be administered in
intranasal form via topical use of suitable intranasal vehicles, or via
transdermal skin patches well known to those skilled in that art.

[1360] It is also apparent to one skilled in the art that the
therapeutically effective dose for active compounds of the invention or a
pharmaceutical composition thereof will vary according to the desired
effect. Therefore, optimal dosages to be administered may be readily
determined and will vary with the particular compound used, the mode of
administration, the strength of the preparation, and the advancement of
the disease condition. In addition, factors associated with the
particular subject being treated, including subject age, weight, diet and
time of administration, will result in the need to adjust the dose to
achieve an appropriate therapeutic level. The above dosages are thus
exemplary of the average case. There can be, of course, individual
instances wherein higher or lower dosage ranges are merited, and such are
within the scope of this invention.

[1361] Compounds of this invention may be administered in any of the
foregoing compositions and dosage regimens or by means of those
compositions and dosage regimens established in the art whenever use of
the compounds of the invention as analgesics is required for a subject in
need thereof.

[1362] The invention also provides a pharmaceutical or veterinary pack or
kit comprising one or more containers filled with one or more of the
ingredients of the pharmaceutical and veterinary compositions of the
invention. Optionally associated with such container(s) can be a notice
in the form prescribed by a governmental agency regulating the
manufacture, use or sale of pharmaceuticals or biological products, which
notice reflects approval by the agency of manufacture, use or sale for
human administration.

[1363] As antagonists of the TRPM8 ion channel, the compounds of Formula
(I) are useful in methods for treating or preventing a disease or
condition in a mammal in which the disease or condition is affected by
the modulation of TRPM8 receptors. Such methods comprise administering to
a mammal in need of such treatment or prevention a therapeutically
effective amount of a compound, salt or solvate of Formula (I). In
particular, the compounds of Formula (I) are useful for preventing or
treating chronic or acute pain, or diseases causing such pain or
conditions, pulmonary or vascular dysfunction. More particularly, the
compounds of Formula (I) are useful for preventing or treating
inflammatory pain, inflammatory hypersensitivity conditions, neuropathic
pain, anxiety and depression by administering to a subject in need
thereof a therapeutically effective amount of a compound of Formula (I).

[1365] One type of inflammatory pain is inflammatory hyperalgesia, which
can be further distinguished as inflammatory somatic hyperalgesia or
inflammatory visceral hyperalgesia. Inflammatory somatic hyperalgesia may
be characterized by the presence of an inflammatory hyperalgesic state in
which a hypersensitivity to thermal, mechanical and/or chemical stimuli
exists. Inflammatory visceral hyperalgesia may also be characterized by
the presence of an inflammatory hyperalgesic state, however, with this
state an enhanced visceral irritability exists.

[1367] One embodiment of the present invention is directed to a method for
treating inflammatory somatic hyperalgesia in which a hypersensitivity to
thermal, mechanical and/or chemical stimuli exists, comprising the step
of administering to a mammal in need of such treatment a therapeutically
effective amount of a compound, salt or solvate of Formula (I).

[1368] A further embodiment of the present invention is directed to a
method for treating inflammatory visceral hyperalgesia in which an
enhanced visceral irritability exists, comprising the step of
administering to a mammal in need of such treatment a therapeutically
effective amount of a compound, salt or solvate of Formula (I).

[1369] A further embodiment of the present invention is directed to a
method for treating neuropathic cold allodynia in which a
hypersensitivity to a cooling stimuli exists, comprising the step of
administering to a mammal in need of such treatment a therapeutically
effective amount of a compound, salt or solvate of Formula (I).

[1372] One type of neuropathic pain is neuropathic cold allodynia, which
may be characterized by the presence of a neuropathy-associated allodynic
state in which a hypersensitivity to cooling stimuli exists. Examples of
neuropathic cold allodynia include allodynia due to a condition selected
from the group consisting of neuropathic pain (neuralgia), pain arising
from spine and peripheral nerve surgery or trauma, traumatic brain injury
(TBI), trigeminal neuralgia, postherpetic neuralgia, causalgia,
peripheral neuropathy, diabetic neuropathy, central pain, stroke,
peripheral neuritis, polyneuritis, complex regional pain syndrome I and
II (CRPS I/II) and radiculopathy.

[1374] Examples of depression are selected from the group consisting of
major depression, bipolar disorder, seasonal affective disorder, post
natal depression, manic depression, and bipolar depression.

[1375] One embodiment of the present invention is directed to a method of
treating or preventing migraine, prophylactic migraine, or hypertension
in a mammal, which method comprises administering to a mammal in need of
such treatment or prevention a therapeutically effective amount of a
TRPM8 antagonist.

[1376] A therapeutically effective amount for use of the instant compounds
or a pharmaceutical composition thereof comprises a dose range from about
0.1 mg to about 3000 mg, in particular from about 1 mg to about 1000 mg
or, more particularly, from about 10 mg to about 500 mg of active
ingredient in a regimen of about 1 to 4 times per day for an average (70
kg) human; although, it is apparent to one skilled in the art that the
therapeutically effective amount for active compounds of the invention
will vary as will the conditions being treated.

[1377] Optimal dosages of the compounds of Formula (I) to be administered
for the treatment of or prevention of TRPM8-mediated disorders may be
readily determined by those skilled in the art, and will vary with the
particular compound used, the mode of administration, the strength of the
preparation, and the advancement of the disease condition. In addition,
factors associated with the particular patient being treated, including
patient age, weight, diet and time of administration, will result in the
need to adjust dosages.

[1378] For oral administration, a pharmaceutical composition is preferably
provided in the form of tablets containing 0.01, 10.0, 50.0, 100, 150,
200, 250, and 500 milligrams of the active ingredient for the symptomatic
adjustment of the dosage to the subject to be treated.

General Synthetic Methods

[1379] Representative compounds of the present invention can be
synthesized in accordance with the general synthetic methods described
below and are illustrated in the schemes that follow. Since the schemes
are an illustration, the invention should not be construed as being
limited by the chemical reactions and conditions expressed. The
preparation of the various starting materials used in the schemes is well
within the skill of persons versed in the art.

[1380] Abbreviations used in the instant specification, particularly the
Schemes and Examples, are as follows:

[1381] Representative compounds of the present invention can be
synthesized in accordance with the general synthetic methods described
below and are illustrated more particularly in the schemes that follow.
Since the schemes are an illustration, the invention should not be
construed as being limited by the chemical reactions and conditions
expressed. The preparation of the various starting materials used in the
schemes is well within the skill of persons versed in the art.

[1382] For illustrative purposes only, the intermediates of the following
Schemes are those wherein D of Formula (I) is d-2. Compounds wherein D of
Formula (I) is d-1 may also be prepared by the general methods described
herein with the appropriate starting materials.

[1383] Scheme A illustrates the synthesis of compounds of Formula (I)
wherein A, D, and W are as defined in Formula (I), and more specifically,
wherein W is C(R4) and R4 is hydrogen or methyl, and X is O or
S. Ra of Scheme A is R1 or R2, wherein is R1 and
R2 are each C1-8alkoxy, and L is (CH2)n.

##STR00023##

[1384] A compound of formula A1 is either commercially available or may be
prepared by known methods described in the scientific literature.
Substituent G of compounds of formula A1 is a functional group that is
readily converted to a methyl alcohol, such as an aldehyde, ester,
anhydride, or carboxylic acid. A compound of formula A1 is converted to a
compound of formula A2 using reagents and methods known to one skilled in
the art. The alcohol functional group of a compound of formula A2 may be
converted to its corresponding bromide of formula A3 using phosphorus
tribromide, or the like. A compound of Formula A3 may be reacted with a
trialkoxy phosphite to yield a compound of Formula A4. Treatment of a
compound of formula A4 with an organometallic base such as
n-butyllithiium or bis-lithium(trimethylsilyl)amide, followed by
alkylation with a compound of formula A5 (wherein B is C6-10aryl or
a heteroaryl as defined herein) affords a compound of Formula (I)-A.
Compounds of formula A5 are either commercially available or may be
prepared by known methods described in the scientific literature. The LG
group of formula A5 is an appropriate leaving group such as chloride,
bromide, or the like.

[1385] Scheme B illustrates an alternate route for the preparation of
certain intermediates of formula A1 wherein R4 is hydrogen or
C1-6alkyl.

##STR00024##

[1386] An alcohol or thiol of formula B1 (X is O or S) maybe alkylated in
the presence of a base and a compound of formula B2 to yield a compound
of formula B3. When X of formula B1 is oxygen, an appropriate base is
sodium hydride; likewise, when X is sulfur, an appropriate base is
pyridine or other tertiary amine. Treatment of a compound of formula B3
with PPA (polyphosphoric acid) provides a cyclized compound of formula
B4. The installation of G may be achieved using reagents and methods
known to one skilled in the art. For example, NBS or bromine in acetic
acid may be used to brominate the vinylic carbon atom adjacent to X.
Subsequent treatment of the vinyl bromide with n-butyllithium and DMF may
generate a compound of formula A1 wherein G is an aldehyde.
Alternatively, the aforementioned bromide may be carboxylated using
carbon dioxide in the presence of a palladium catalyst in an aprotic
solvent to afford a compound of formula A1 wherein G is a carboxyl group.
Similarly, a compound of formula A1 wherein G is an ester may be prepared
by the treatment via alkoxy-carbonylation of the vinyl bromide with
carbon dioxide in the presence of a palladium catalyst in an alcoholic
solvent.

[1387] Scheme C illustrates an alternate route for the synthesis of
intermediates of formula C4 wherein W is C(R4) and R4 is other
than C1-6alkoxy, C1-6alkoxycarbonyl. In Scheme C, X is O or S
and G is an ester.

##STR00025##

[1388] A compound of formula C1 is either commercially available or may be
prepared by known methods described in the scientific literature. A
compound of formula C1 may be treated with a base such as sodium hydride
(or TEA when R4 is trifluoromethyl), followed by the addition of an
α-hydroxy or a-thiol substituted ester of formula C2 to afford a
compound of formula C3. A compound of formula C3 may be further reacted
using the synthetic methods described herein above to form a compound of
formula C4.

[1389] Scheme D illustrates the synthesis of certain compounds of Formula
(I) wherein A and D are as defined herein, and specifically wherein W is
C(R4) and R4 is bromo, chloro, C6-10aryl, or a heteroaryl;
X is O or S; R1 and R2 are each C1-8alkoxy or
C1-8alkyl, and L is (CH2)n.

##STR00026##

[1390] A compound of Formula (I)-D1 wherein R4 is hydrogen may be
treated with N-bromosuccinimide to give a compound of Formula (I)-D2
wherein R4 is bromo. Similarly, a compound of Formula (I)-D1 may be
converted to a compound of Formula (I)-D2 (wherein R4 is chloro) by
treatment with a chlorinating agent such as N-chlorosuccinimide or the
like. A compound of Formula (I)-D2 may be cross-coupled with a boronic
acid of formula D1 (wherein R4 is phenyl or a heteroaryl as defined
herein) in the presence of carbonate anion and a palladium catalyst to
afford a compound of Formula (I)-D3. A compound of Formula (I)-D2 wherein
R4 is bromo may also be useful as an intermediate for the
preparation of compounds wherein R4 is C1-6alkoxycarbonyl or
cyano. A compound of Formula (I) wherein R4 is
C1-6alkoxycarbonyl may be prepared by a palladium catalyzed
alkoxy-carbonylation in the presence of an alcoholic solvent such as
methanol, ethanol, or the like. Similarly, compound of Formula (I)
wherein R4 is cyano may be prepared by a palladium catalyzed
reaction in the presence of zinc (II) cyanide.

[1391] Scheme E illustrates the synthesis of compounds of Formula (I)
wherein X is O or S, and R1 and R2 are each C1-8alkyl.

##STR00027##

[1392] A compound of formula E1 is either commercially available or may be
prepared by known methods in the scientific literature. A trialkoxy
phosphite of formula E2 may be treated with a compound of formula E1 to
form a compound of formula E3. A compound of formula E3 may be
deprotonated at the phosphorus atom and alkylated with a compound of
formula A3 to form a compound of Formula E4. A compound of formula E4 may
be treated with an organometallic base such as n-butyllithium and
alkylated with a compound of formula A5 to afford a compound of Formula
(I)-E.

[1393] Scheme F illustrates the synthesis of compounds of Formula (I)
wherein X is O or S, and R1 and Rb are each C1-8alkyl.

##STR00028##

[1394] A compound of formula F1 (wherein Rb is C1-8alkyl) may be
treated with a compound of formula F2 in the presence of aqueous
carbonate anion to form a compound of formula F3. A compound of formula
F3 may be deprotonated with a strong base and treated with a compound of
formula A3 to form a compound of formula F4. A compound of formula F4 may
be deprotonated and subsequently alkylated with a compound of formula A3
as described herein to yield a compound of Formula (I)-F.

[1395] Scheme G illustrates the synthesis of compounds of Formula (I)
wherein X is O or S, and R1 is C1-8alkoxy and R2 is
C1-8alkoxy or C1-8alkyl. More specifically, Scheme G describes
the preparation of compounds in which R1 is a C1-8alkoxy
substituted with an appropriate substituent as defined in Formula (I).

##STR00029##

[1396] A compound of Formula (I)-G may be treated with sodium azide to
form a compound of formula G1. The hydroxy substituent of formula G1 may
be coupled with a R1b-substituted alcohol of formula G2 in the
presence of a standard coupling agent, such as MSNT, to afford a compound
of Formula (I)-G1.

[1397] Scheme H illustrates the synthesis of compounds of Formula (I)
wherein R3 is methyl, and D is d-1 or d-2.

##STR00030##

[1398] A compound of formula A4 may be treated with a base, such as
n-butyllithium, followed by addition of a methylating agent such as
methyl iodide to install a methyl group of R3. Subsequent treatment
with a second equivalent of n-butyllithium followed by alkylation with a
compound of formula A5 affords a compound of Formula (I)-H.

[1399] Scheme I illustrates the synthesis of compounds of Formula (I)
wherein X is S(═O) or S(O2) and D is d-1 or d-2.

##STR00031##

[1400] A compound of Formula (I)-I1 wherein X is sulfur may be treated
with an oxidizing agent such as oxone, hydrogen peroxide, sodium
hypochlorite, or the like, to afford a mixture of compounds of Formula
(I)-I2 and Formula (I)-I3. Isolated compounds may be obtained from the
mixture using separation techniques known to one of skill in the art.

[1401] Scheme J illustrates the synthesis of compounds of Formula (I)
wherein L is absent, R3 is hydrogen, and D is d-1 or d-2.

##STR00032##

[1402] A compound of formula A1 wherein G is an aldehyde may be treated
with a B-substituted Grignard reagent of formula J1 to form the alcohol
of formula J2. Treatment of the alcohol with a brominating agent such as
phosphorus tribromide or the like affords a compound of formula J3, which
may be phosphorylated according to the methods described herein to form a
compound of Formula (I)-J.

[1403] Scheme K illustrates the preparation of compounds of Formula (I)
wherein R3 is fluoro, R1 and R2 are C1-6alkoxy, and D
is d-1 or d-2.

##STR00033##

[1404] A compound of formula A1 wherein G is an aldehyde may be treated
with a phosphorylating agent of formula K1 to form an alcohol of formula
K2. The alcohol of formula K2 may be oxidized with an appropriate
oxidizing agent, such as manganese (IV) oxide or DDQ, to form the
corresponding carbonyl compound of formula K3. Treatment of a compound of
formula K3 with DAST ((diethylamino)sulfur trifluoride) affords the
fluorinated compound of formula K4. Treatment of a compound of formula K4
with an organometallic base such as n-butyllitihium, followed by
alkylation with a compound of formula A5 provides a compound of formula
(I)-K.

[1405] Scheme L describes the preparation of compounds of the present
invention wherein R1 and R2 are C1-6alkoxy, R3 is
hydroxy, and D is d-1 or d-2.

##STR00034##

[1406] A compound of formula K2 may be O-protected using conventional
reagents and methods (wherein P is a hydroxy protecting group) to afford
a compound of formula L1. Treatment of a compound of formula L1 with an
organometallic base followed by alkylation with a compound of formula A5
provides a compound of formula L2. Removal of hydroxy-protecting group P
may be achieved using conventional methods to afford a compound of
Formula (I)-L.

[1407] Scheme M describes the preparation of certain compounds of Formula
(I) wherein W is C(R4) and R4 is C1-6alkoxy, X is O, S, or
N--R6, and ring A is benzo. D is d-1 or d-2.

##STR00035##

[1408] A compound of formula M1 may be cyclized with a compound of formula
M2 to form a fused ring system of formula M3. The hydroxy substituent of
M3 may be alkylated with a standard alkylating agent (wherein LG is
defined herein) to form an R4-- alkoxy substituent of formula M4.
Reduction of the ester group of a compound of formula M4 using a borane
complex, lithium aluminum hydride, or the like, provides a primary
alcohol of formula M5 which may be converted to its corresponding bromide
using reagents and methods taught herein. The bromide may then be
phosphorylated and then alkylated with a compound of formula A5 to form a
compound of Formula (I)-M.

[1409] Scheme N describes the preparation of certain intermediates to
prepare compounds of Formula (I) wherein W is C(R4) and R4 is
C1-6alkoxy, X is O, S, or N--R6, and ring A is pyrido. D is d-1
or d-2.

##STR00036##

[1410] A compound of formula N1 may be cyclized with a compound of formula
N2 (wherein X is S, O, or N--R6) to form a fused ring system of
formula N3. A compound of formula N3 may be further elaborated to a
compound of Formula (I) using the synthetic sequence described for
compounds of formula M3.

[1411] Scheme P describes the preparation of certain compounds of Formula
(I) wherein R4 is bromo or chloro, X is N--H (wherein R6 is H),
and ring A is benzo. D is d-1 or d-2.

##STR00037##

[1412] A compound of formula P1 may be treated with DMSO, potassium
t-butoxide, and acetone to form a 2-methyl substituted indole of formula
P2. The indole nitrogen may be protected using a standard nitrogen
protecting group (PG) to give a compound of formula P3. The 3-position of
the indole may be chlorinated or brominated using N-chlorosuccinimide or
N-bromosuccinimide, respectively, to give a compound of formula P4
(wherein R4 is chloro or bromo). The methyl group of a compound of
formula P4 may be converted to its methyl bromide using a brominating
agent such as N-bromosuccinimide to afford a compound of formula P5 that
is readily phosphorylated, according to the methods described herein, to
give a compound of formula P6. Alkylation with a compound of formula A5
yields a compound of formula P7, which, upon removal of the nitrogen
protecting group PG, affords a compound of Formula (I)-P. The indole
amino group (wherein X═NH) may be substituted with other R6
substituents of the present invention using conventional synthetic
methods and reagents to provide compounds of Formula (I)-P1. For example,
an alkyl halide, allyl bromide, acid chloride, or sulfonyl chloride may
be used for the installation of the respective R6 groups. Arylation
of the indole amine may be achieved by nucleophilic aromatic displacement
to afford compounds wherein R6 is phenyl. Treatment of the indole
amine with a strong base such as sodium hydride, followed by the addition
of a fluoro-substituted pyridinyl will afford a compound of Formula (I)
wherein R6 is pyridinyl.

[1413] Scheme Q describes the preparation of certain compounds of Formula
(I) wherein W is C(R4), X is O, S, or N--R6, and ring A is
benzo substituted with aminocarbonyl, (C1-2alkyl)aminocarbonyl, or
di(C1-2alkyl)aminocarbonyl. In Scheme Q, D is d-1 or d-2, and
R30 and R31 are hydrogen or C1-2alkyl.

##STR00038##

[1414] A compound of formula Q1 may be cyclized with a compound of formula
C2 to form a fused ring system of formula Q2. Using chemistry described
herein in Scheme B, a compound of formula Q2 can be converted to a
compound of formula Q3. Reduction of substituent G of a compound of
formula Q3 using a hydride source, borane complex, lithium aluminum
hydride, or the like, provides a primary alcohol of formula Q4. A
compound of formula Q4 may be converted to its corresponding bromide
using reagents and methods taught herein. The bromide may then be
phosphorylated and subsequently alkylated with a compound of formula A5
to form a compound of formula Q5. Carbonylation of a compound of formula
Q5 to afford a compound of formula Q6 may be achieved using a palladium
source, such as dichlorobis(triphenylphosphine)palladium (II), carbon
monoxide, and a suitable alcoholic solvent, such as ethanol or methanol.
Subsequent hydrolysis of the ester of a compound of formula Q6 may be
achieved using known methods in the scientific literature to afford a
compound of formula Q7, which can be coupled with an amine of formula
HNR30R31 using known methods in the scientific literature to
afford a compound of Formula (I)-Q.

[1415] Scheme R describes the preparation of certain compounds of Formula
(I) wherein W is C(R4) and R4 is a C1-6alkoxycarbonyl
substituent, X is O, S, or N--R6, and ring A is benzo or pyrido. D
is d-1 or d-2.

##STR00039##

Carbonylation of a compound of Formula (I)-D2 to afford a compound of
formula Formula (I)-R may be achieved using a palladium source, such as
dichlorobis(triphenylphosphine)palladium (II), carbon monoxide, and a
suitable alcoholic solvent (C1-6alkyl-OH).

[1416] Scheme S describes the preparation of certain compounds of Formula
(I)-S wherein W is C(R4), wherein R4 is cyano, X is O, S, or
N--R6, and ring A is a benzo or pyrido. D is d-1 or d-2.

##STR00040##

[1417] Cyanation of a compound of Formula (I)-D2 to afford a compound of
formula Formula (I)-S may be achieved using a cyanide source, such as
zinc cyanide, copper (I) cyanide, or sodium cyanide, and an appropriate
solvent, such as dimethylformamide, N-methylpyrrolidine, or
dimethylacetamide (DMA).

##STR00041##

[1418] Scheme T illustrates the preparation of intermediate T3 wherein W
is C(R4), R4 is bromo, X is O, S, or N-PG, and ring A is a
benzo or pyrido. D is d-1 or d-2.

[1419] A 2-methyl substituted compound of formula T1 may be treated with
bromine and sodium acetate in acetic acid to form a compound of formula
T2 wherein R4 is bromo. The 2-methyl substituent of a compound of
formula T2 may be converted to its corresponding 2-methyl bromide T3
using N-bromosuccinimide. Compounds of formula T3 may be converted to
certain compounds of Formula (I) using analogous chemistry to that
described for compounds of formula A3 to compounds of Formula (I).

[1420] Alternatively, a compound of formula T3 may be phosphonylated to
the corresponding compound of formula T4 according to the conditions
described in Scheme A for the conversion of a compound of formula A3 to a
compound of formula A4. Subsequently, a compound of formula T4 may be
taken to form compounds of Formula (I) using potassium t-butoxide in
THF/diethyl ether at about 55° C. in place of the reaction
conditions described in Scheme A for the conversion of a compound of
formula A4 to a compound of formula Formula (I)-A.

##STR00042##

[1421] Scheme U illustrates the synthesis of compounds of Formula (I)
wherein L is ═CH-- and R3 is absent; W is C(R4); R4 is
as described herein; X is O, S, or N--R6; and ring A is a benzo or
pyrido. D is d-1 or d-2 and R1 and R2 are each C1-8alkoxy.

[1422] To a solution of compound U1 under basic conditions is added an
aldehyde of formula U2. Upon heating, a compound of formula U3 is formed,
and the resulting alkenyl functionality may be brominated using bromine
under acidic conditions to form a dibromide of formula U4. Upon addition
of a base such as a tertiary amine, a mixture of alkenes of formulae U5
and U6 may be prepared. The alkene may then be coupled with a boronic
acid of formula U7 in the presence of a transition metal catalyst, under
basic conditions, to form a compound of Formula (I)-U

[1423] Compounds of Formula (I) may be prepared enantioselectively by
reaction of a compound of formula VI with a compound of formula A5 in the
presence of the chiral catalyst
(R,R)-2,6-bis(3,4,5-trifluorophenyl)-3,3',5,5'-tetrahydro-4,4'-spirobi[di-
naphtho[2,1-c:1',2'-e]azepin]-4-ium bromide or
(S,S)-2,6-bis(3,4,5-trifluorophenyl)-3,3',5,5'-tetrahydro-4,4'-spirobi[di-
naphtho[2,1-c:1',2'-e]azepin]-4-ium bromide, under basic conditions to
form the appropriate chiral product of formula (I)-V.

##STR00043##

SPECIFIC EXAMPLES

Example 1

##STR00044##

[1425] A. 3-Methyl-benzo[b]thiophene-2-carboxyaldehyde. To a solution of
3-methyl-benzo[b]thiophene (Compound 1a) (4.87 g; 30.1 mmol) in anhydrous
THF (50 mL), cooled to -69° C., was added a solution of 2.5 M
n-butyllithium in hexanes (14.4 mL; 36.0 mmol), dropwise. The reaction
was allowed to stir at -69° C. for 1 h, to which was then added
anhydrous DMF (5.0 mL; 64.5 mmol), dropwise. The reaction was allowed to
warm to ambient temperature, and was then refluxed for 1 h. At that time,
the reaction was cooled, diluted with EtOAc, washed sequentially with
H2O and brine, and dried over Na2SO4. The mixture was
filtered and the solvent evaporated under reduced pressure to afford
Compound 1b. 1H-NMR (300 MHz, DMSO-d6): δ 10.34 (s, 1H),
7.85-7.90 (m, 2H), 7.42-7.53 (m, 2H), 2.79 (s, 3H).

[1426] B. (3-Methyl-benzo[b]thiophene-2-yl)-methanol. To a stirred
solution of Compound 1b (2.3 g; 13.0 mmol) in MeOH (30 mL) was added
sodium borohydride (1.0 g; 26.4 mol), in three equal portions, at ambient
temperature. The reaction mixture was stirred for 18 h at room
temperature, and then the solvent was evaporated in vacuo. The resultant
residue was partitioned between EtOAc and H2O, and the layers were
separated. The organic phase was washed sequentially with H2O and
brine, and dried over Na2SO4. The mixture was filtered and the
solvent removed under reduced pressure to afford Compound 1c. 1H-NMR
(300 MHz, DMSO-d6): δ 8.08-8.10 (d, 1H), 7.89-7.91 (d, 1H),
7.49-7.59 (m, 2H), 5.72-5.75 (t, 1H), 4.92-4.94 (d, 2H), 2.53 (s, 3H).

[1427] C. 2-Bromomethyl-3-methyl-benzo[b]thiophene. To Compound 1c (2.19
g, 12.3 mmol) dissolved in anhydrous ether (40 mL) was added phosphorous
tribromide (0.583 mL; 18.4 mmol) dropwise at ambient temperature. The
reaction was stirred at ambient temperature for 1 h, diluted with EtOAc,
washed sequentially with saturated NaHCO3, H2O, and brine, and
then dried over Na2SO4. The mixture was filtered and the
filtrate was evaporated under reduced pressure to afford Compound 1d.
(Note: material is unstable and is used immediately in next step.)

[1430] Following the procedure described above for Example 1 and
substituting the appropriate reagents, starting materials and
purification methods known to those skilled in the art, the following
compounds of the present invention were prepared:

[1442] A. 1-Bromo-3-methyl-butan-2-one. To a solution of
3-methyl-2-butanone (6.0 g; 69.7 mmol), dissolved in MeOH (40 mL), cooled
to 0° C., was added bromine (3.56 mL; 69.7 mmol), at a rate such
that the internal temperature did not exceed 10° C. The reaction
was allowed to stir for 45 min at 5-10° C., to which was then
added H2O (20 mL) and the reaction was stirred for an additional 18
h at ambient temperature. Water was added to the reaction mixture, which
was then extracted with diethyl ether. The combined ether extracts were
washed sequentially with 10% aq. NaHCO3, H2O, and brine, dried
over Na2SO4, filtered, and the filtrate was evaporated under
reduced pressure to afford Compound 2b. 1H-NMR (300 MHz,
CDCl3): δ 3.98 (s, 2H), 2.95-3.02 (m, 1H), 1.10-1.17 (d, 6H).

[1449] Following the procedure described above for Example 2 and
substituting the appropriate reagents, starting materials and
purification methods known to those skilled in the art, the following
compounds of the present invention were prepared:

[1454] Following the procedure described above for Example 3 and
substituting the appropriate reagents, starting materials and
purification methods known to those skilled in the art, the following
compounds of the present invention were prepared:

[1465] B. (3-Methyl-thieno[2,3-b]pyridin-2-yl)-methanol. To a solution 1.0
M LAH in THF (8.6 mL), cooled to 0° C., was added a solution of
Compound 4b (0.632 g; 2.85 mmol), dissolved in THF (10 mL), dropwise, and
the reaction was stirred at 0° C. for 2 h. The reaction was
quenched with H2O, extracted with EtOAc, and the organic phase was
washed sequentially with H2O and brine, dried over Na2SO4,
filtered and the filtrate was concentrated under reduced pressure to
afford Compound 4c.

[1466] C. 2-Bromomethyl-3-methyl-thieno[2,3-b]pyridine. To a solution of
Compound 4c (0.210g; 1.17 mmol), in DCE (3.0 mL), was added thionyl
bromide (0.182 mL; 2.34 mmol) at ambient temperature. The reaction was
refluxed for 3 h, cooled, diluted with EtOAc, and washed sequentially
with 10% NaHCO3, H2O, and brine. The organic phase was dried
over Na2SO4, filtered, and the filtrate was concentrated under
reduced pressure to afford Compound 4d.

[1469] Following the procedure described above for Example 4 and
substituting the appropriate reagents, starting materials and
purification methods known to those skilled in the art, the following
compounds of the present invention were prepared:

[1477] Following the procedure described above for Example 5 and
substituting the appropriate reagents, starting materials and
purification methods known to those skilled in the art, the following
compounds of the present invention were prepared:

[1488] Following the procedure described above for Example 6 and
substituting the appropriate reagents, starting materials and
purification methods known to those skilled in the art, the following
compounds of the present invention were prepared:

[1489] Cpds 135 and 136:
[2-(3,4-Difluoro-phenyl)-1-(3-methyl-benzo[b]thiophene-2-yl)-ethyl]-[3-(4-
-methoxy-phenyl)-propyl]-phosphonic acid ethyl ester. Compounds 135 and
136 were prepared by the method described in Example 6, substituting
[3-(4-methoxy-phenyl)-propyl]-(3-methyl-benzo[b]thiophen-2-ylmethyl)-phos-
phinic acid ethyl ester (prepared according to the procedures described in
United States patent application US 20050176769) for Compound 6c in Step
C. The diastereomers were separated by reverse-phase semi-prep HPLC
(J-sphere, ODS-H80 column; 100×30 mm I.D.; S-4 μM) eluting with
a 60% to 80% MeCN--H2O gradient.

[1500] Following the procedure described above for Example 7 and
substituting the appropriate reagents, starting materials and
purification methods known to those skilled in the art, the following
compounds of the present invention were prepared:

[1510] Following the procedure described above for Example 10 and
substituting the appropriate reagents, starting materials and
purification methods known to those skilled in the art, the following
compounds of the present invention were prepared:

[1513] Following the procedure described above for Example 11 and
substituting the appropriate reagents, starting materials and
purification methods known to those skilled in the art, the following
compounds of the present invention were prepared:

[1516] Following the procedure described above for Example 12 and
substituting the appropriate reagents, starting materials and
purification methods known to those skilled in the art, the following
compounds of the present invention were prepared:

[1520] Following the procedure described above for Example 13 and
substituting the appropriate reagents, starting materials and
purification methods known to those skilled in the art, the following
compound of the present invention was prepared:

[1523] Following the procedure described above for Example 14 and
substituting the appropriate reagents, starting materials and
purification methods known to those skilled in the art, the following
compounds of the present invention were prepared:

[1527] B. [1-(3-Dimethylaminomethyl-benzo[b]thiophen-2-ylmethyl)-phosphoni-
c acid diethyl ester. To a solution of Compound 15a (0.139 g; 0.368 mmol)
in MeOH (2.0 mL) was added a 2M solution of dimethylamine in methanol
(5.0 mL) and the reaction was heated at 65° C. in a pressure tube.
The reaction was cooled, diluted with EtOAc, and washed with 10% NaOH,
H2O and brine. The organic phase was dried over Na2SO4,
filtered, and the filtrate was concentrated under reduced pressure. The
crude residue was purified by flash column chromatography (SiO2),
eluting with a heptane-EtOAc gradient to afford Compound 15b. LC/MS
C16H24NO3PS: m/z 341.9 (M.sup.+).

[1531] Following the procedure described above for Example 16 and
substituting the appropriate reagents, starting materials and
purification methods known to those skilled in the art, the following
compounds of the present invention were prepared:

[1536] B. 3-Bromo-2-bromomethyl-benzo[b]thiophene. To a solution of
Compound 17b (15.6 g; 69 mmol) in CCl4 (200 mL) was added
N-bromosuccinimide (14.7 g; 83 mmol) and the reaction was refluxed for 24
h. The reaction was cooled and then concentrated under reduced pressure.
The resultant residue was purified by flash column chromatography
(SiO2) eluting with a heptane-EtOAc gradient to afford Compound 17c.

[1539] Following the procedure described above for Example 17 and
substituting the appropriate reagents, starting materials and
purification methods known to those skilled in the art, the following
compounds of the present invention were prepared:

[1558] Following the procedure described above for Example 18 and
substituting the appropriate reagents, starting materials and
purification methods known to those skilled in the art, the following
compounds of the present invention were prepared:

[1562] Following the procedure described above for Example 19 and
substituting the appropriate reagents, starting materials and
purification methods known to those skilled in the art, the following
compounds of the present invention were prepared:

[1570] Following the procedure described above for Example 20 and
substituting the appropriate reagents, starting materials and
purification methods known to those skilled in the art, the following
compounds of the present invention were prepared:

[1573] Following the procedure described above for Example 21 and
substituting the appropriate reagents, starting materials and
purification methods known to those skilled in the art, the following
compounds of the present invention were prepared:

[1585] Following the procedure described above for Example 24 and
substituting the appropriate reagents, starting materials and
purification methods known to those skilled in the art, the following
compounds of the present invention were prepared:

[1596] An alternate route to compounds of the present invention is
presented herein.

##STR00070##

[1597] A. (3-Bromo-benzo[b]thiophen-2-ylmethyl)-phosphonic acid
diisopropyl ester. A mixture of Cpd 17c (100 g, 326.8 mmol) and
triisopropyl phosphite (76.7 mL, 326.8 mmol) were heated at 55° C.
for 2 h. Upon cooling, some of Cpd 26a precipitated and was isolated by
filtration. The filtrate was evaporated under reduced pressure. The
filtered solids and filtrates were each separately purified by flash
column chromatography (SiO2) using a heptane-EtOAc gradient. The
desired fractions were combined and slurried in heptane (100 mL) with
sonication, filtered, and washed with heptane (3×20 mL). The solid
was first air-dried before being transferred to dry in a vacuum oven at
40° C. (20 mm). The desired Compound 26a was obtained as a white
solid.

[1606] The functional activity of compounds of Formula (I) was determined
by measuring changes in intracellular calcium concentration using a
Ca2+-sensitive fluorescent dye. The changes in fluorescent signal
were monitored by a fluorescence plate reader, either a FLIPR®
(Molecular Devices) or FDSS (Hamamatsu). Increases in intracellular
Ca2+concentration were readily detected upon activation with icilin.

[1607] HEK293 cells stably expressing canine TRPM8 were routinely grown as
monolayers in Dulbecco's minimum essential medium supplemented with 10%
FBS, 1 mM L-glutamine, 100 units/mL penicillin, 100 ug/mL streptomycin
and 400 μg/mL G418. Cells were maintained in 5% CO2 at 37°
C. At 24 hrs prior to assay, cells were seeded in clear-base
poly-D-lysine coated 384-well plates (BD Biosciences, NJ, USA) at a
density of 5,000 cells per well in culture medium and grown overnight in
5% CO2 at 37° C. On assay day, growth media was removed and
cells were loaded with Calcium 3 Dye (Molecular Devices) for 35 min at
37° C., under 5% CO2 and then for 25 min at room temperature
and atmosphere. Subsequently, cells were tested for agonist-induced
increases in intracellular Ca2+ levels using FLIPR® or FDSS.
Cells were challenged with a compound of Formula (I) (at varying
concentrations) and intracellular Ca2+ was measured for 5 min prior
to the addition of icilin to all wells to achieve a final concentration
which produces approximately an 80% maximal response. EC50 or
IC50 values for compounds of the present invention were determined
from eight-point dose-response studies and represent the concentration of
compound required to elicit or inhibit 50% of the maximal response,
respectively.

[1608] Maximal fluorescence intensity (FI) achieved upon addition of
icilin was exported from the FLIPR or FDSS software and further analyzed
using GraphPad Prism 3.02 (Graph Pad Software Inc., CA, U.S.A.). Basal FI
was subtracted prior to normalizing data to percent of maximal response.
Curves were generated using the average of quadruplicate wells for each
data point, were analyzed using nonlinear regression of either sigmoidal
dose response or sigmoidal dose response (variable slope). Finally, the
EC50 and IC50 values were calculated with the best-fit dose
curve determined by GraphPad Prism. The resultant data are displayed in
Table 4.

[1609] Icilin was initially developed as a "super-cooling" compound by
Delmar Chemicals Ltd. Subsequently it was shown to be one of the most
potent known agonists of TRPM8 (McKemy D D, et al. Nature 2002,
416(6876): 52-8), having an EC50=0.2 μM in stimulating calcium
ion influx into TRPM8 transfected cells (Behrendt H J et al. Brit J
Pharmacol 2004, 141(4): 737-45). Initial in vivo testing of icilin showed
it to cause "wet-dog" shakes in rats. Similar shaking or jumping behavior
was also evident in mice, rabbits, cats, dogs and monkeys. In humans,
icilin produced a sensation of coolness on contact with mucous membranes,
cold prickling when 0.1 mg was dropped on the tongue and coldness in the
mouth, pharynx and chest lasting 30-60 minutes when 5-10 mg was ingested
orally (Wei E T, Seid D A, J Pharm Pharmacol. 1983, 35, 110). The
inhibition of icilin-induced shaking behaviors in rodents provides
evidence for the utility of TRPM8 antagonists of Formula (I) in
modulating TRPM8-mediated effects in vivo.

[1611] Compounds of Formula (I) capable of inhibiting the onset of
icilin-induced "wet-dog" shaking behavior may be further assessed for
their ability to reverse an existing icilin-induced "wet-dog" shaking
behavior. In this paradigm, icilin-induced shaking was counted for 10
minutes followed by administration of a compound of Formula (I). The
diminution of shaking behavior is represented as a percent inhibition
relative to icilin-induced shakes in the absence of test compound
administration, as described by the following formula: %
Inhibition=[1-(WDS count following test compound dose/WDS count prior to
test compound dose)]×100. The resultant data are shown in Table 6.

[1612] Intraplantar injection of Complete Freund's Adjuvant (CFA) in
rodents results in a long-lasting inflammatory reaction, characterized by
a pronounced hypersensitivity to both thermal and mechanical stimuli.
This hypersensitivity peaks between 24-72 hours following injection and
can last for several weeks. To assess whether test compounds of Formula
(I) reverse established hypersensitivity, a 100 μL intraplantar
injection of CFA (suspended in a 1:1 emulsion of saline and heat-killed
Mycobacterium tuberculosis in mineral oil) was injected into a single
hind paw of Sprague-Dawley rats (typically males ranging from 150-350g).
This paradigm also may be conducted with a multiple dosing or a
prophylactic dosing regime designed to alter the course of hyperalgesia
development. This test predicts the analgesic, anti-allodynic and
antihyperalgesic effect of numerous effective clinical agents, including
NSAIDS such as acetaminophen, aspirin and ibuprofen, and opioids such as
morphine.

Example 3a

CFA-induced Paw Radiant Heat Hypersensitivity

[1613] Each rat was placed in a test chamber on a warm glass surface and
allowed to acclimate for approximately 10 minutes. A radiant thermal
stimulus (beam of light) was then focused through the glass onto the
plantar surface of each hind paw in turn. The thermal stimulus was
automatically shut off by a photoelectric relay when the paw was moved or
when the cut-off time was reached (20 seconds for radiant heat at
˜5 Amps). An initial (baseline) response latency to the thermal
stimulus was recorded for each animal prior to the injection of CFA.
Twenty-four hours following intraplantar CFA injection, the response
latency of the animal to the thermal stimulus was then re-evaluated and
compared to the animal's baseline response time. Only rats that exhibited
at least a 25% reduction in response latency (i.e. hyperalgesia) were
included in further analysis. Immediately following the post-CFA latency
assessment, test compound or vehicle (usually Solutol, hydroxypropyl
methylcellulose, hydroxypropyl beta-cyclodextrin or PEG-400) was
administered i.p. or p.o. to rats. Post-compound treatment withdrawal
latencies were assessed at fixed time intervals, typically 30, 60 and 120
minutes. The percent reversal (% R) of hypersenstivitiy was calculated
according to the following formula: % Reversal=(Treatment Response-CFA
Response)/(Baseline Response-CFA Response)×100.

[1614] A 3-point dose-response study in the CFA-induced Paw Radiant Heat
model, using a 10% solutol vehicle, was obtained. A dose-dependent
reversal of hyperalgesia was observed, with an oral ED50 of 11.4
mg/kg and 5.2 mg/kg for Compounds 15 and 127, respectively, at the 1 h
time point.

Example 3a

CFA-induced Paw Cold Hypersensitivity

[1615] Prior to intraplantar CFA injection mice were placed individually
in elevated observation chambers having wire mesh floors. Through the
mesh floor a series of three applications of acetone (0.04
mL/application) was sprayed onto the bottom of the paw using a multidose
syringe device. A positive response took the form of an abrupt withdrawal
and licking of the paw. The cumulative duration of licking was recorded
for each of the three trials which were then averaged to give the
individual's response. Twenty-four hours following CFA injection acetone
licking durations were markedly elevated implying a hypersensitivity to
cooling. A test compound of Formula (I) was assessed for its ability to
return acetone-evoked paw licking durations to pre-CFA levels (typically
near zero) following systemic administration. Percent inhibition was
calculated % Inhibition=[1-(treatment licking duration/vehicle licking
duration)]×100. The resultant data are displayed in

[1616] A chemical irritant (such as acetic acid, kaolin, bradykinin,
phenyl-p-(benzo) quinine, bromo-acetylcholine, or zymosan) is injected in
mice intraperitoneally, causing a contraction of the abdominal
musculature, which is characterized by an elongation of the body
extending through to the hind limbs. The number of such responses is
quantitated and is reduced by pretreatment of analgesic agents, thus
forming the basis for a screening test (Collier H O et al. Br J Pharmacol
Chemother 1968, 32(2): 295-310). This type of abdmonial irritant test has
been used to predict the analgesic effect of numerous clinically
effective agents, the potency of which in the abdominal irritant test
parallels the magnitude of the dose needed in the relief of clinical
pain.

[1617] One modification of the chemically-induced abdmonial irritant model
of visceral pain is to pretreat animals with agents known to induce
inflammatory responses following intraperitoneal injection (such as LPS,
zymosan, or thioglycolate). A small intraperitoneal dose of such an
inflammogen, administered hours or days before the acute chemical
irritant challenge, has been shown to increase the number of abdominal
contractions observed (Ribeiro R A, et al. Eur J Pharmacol 2000, 387(1):
111-8). While some analgesic agents are effective at mitigating acute
viscerochemical nociception, others, particularly those dependent upon
receptor induction are more effective at preventing or reversing the
enhancement of behavioral responses caused by a preconditioning
inflammatory stimulus. Because of the up-regulation of the TRPM8 receptor
in inflammation, TRPM8 antagonists that are effective at reducing the
mean number of contractions are predicted to provide antiinflammatory
action in human clinical use.

[1618] The ability of compounds of Formula (I) to mitigate chemical
irritant--induced abodominal contractions following a pre-conditioning
inflammatory stimulus were studied. Thioglycolate (3%, w/v, 2-3 mL i.p.)
was injected into male CD1 mice (20-40g, Charles River Labs), at a
maximum dosage volume of 80 mL/kg, to induce peritoneal inflammation.
Following a twenty-four hour pre-inflammation period these mice were
dosed orally with a compound of Formula (I) (30 mg/kg; n=10) or vehicle
(HPMC with 2% Tween80; n=9) and then one hour later subjected to an
abdominal irritant challenge of acetic acid (1%, 10 mL/kg, i.p.).
Immediately following injection of acetic acid, mice were placed
individually in glass bell jars (approximately 15 cm in diameter) for
counting of abdominal contractions over the next 15 minutes. The total
number of abdominal contractions was summed for each treatment group and
employed in the following formula to calculate Percent Inhibition (% I):

[1620] The sciatic nerve is the major sensorimotor innervation of the
(hind) leg and foot. Injury to the sciatic nerve or its constituent
spinal nerves often results in pain-related behaviors. In rats and mice,
tight ligation of the L5 spinal nerve with silk suture, partial tight
ligation of the sciatic nerve with silk suture or loose ligation of the
sciatic nerve with chromic gut suture each result in behaviors
reminiscent of neuropathic pain in humans. These lesions (one per animal)
were performed surgically in anesthetized rodents. Both the spinal nerve
and sciatic nerve lesions result in allodynia, a painful response to
normally innocuous stimuli, and hyperalgesia, an exaggerated response to
normally noxious stimuli. It is important to note that both of these
pain-related behaviors were evoked by the testing procedures and that
normal use of the paw (e.g., walking) was relatively uncompromised, apart
from occasional "guarding" of the paw. Subsequent to the surgery, the
subjects' behaviors, such as grooming, feeding, and weight gain, were
normal, except for hypersensitivity (as defined above) of the affected
paw.

[1621] In addition to induction by nerve damage resulting from accidental
trauma or surgical procedures, neuropathic pain can also be induced by
diabetes (Fox, A et al., Pain 81:307-316, 1999) or by treatment with
chemotherapeutic agents, such as paclitaxel or vincristine (Yaksh, T L et
al., Pain 93:69-76, 2001).

[1623] In male SD rats (175-325g), four loose ligatures of 4-0 chromic gut
were surgically placed around the left sciatic nerve under inhalation
anesthesia as described by Bennet et al (Bennett G J, Xie Y K. Pain 1988,
33(1): 87-107). Seven to 21 days following sciatic chronic constriction
injury (CCI) surgery, the subjects were placed in elevated observation
chambers having wire mesh floors. Through the mesh floor a series of five
applications of acetone (0.05 mL/application) was sprayed onto the bottom
of the paw using a multidose syringe device. A positive response took the
form of an abrupt withdrawal or lifting of the paw. The percentage of
positive responses from the five trials represented the individual's
overall response that was then averaged over the entire treatment group.
A test compound of Formula (I) was assessed for its ability to return
acetone response frequencies to pre-lesion levels (typically zero)
following systemic administration. An ascending dose response
relationship (as in Table 10 below) was generated by addition of
successive doses of test compound followed by re-assessment of behavior.
The number of positive responses following administration of test
compound was taken as a percentage of the number of positive responses
prior to test compound treatment. The resultant data are displayed in
Table 10.

[1624] In male SD rats (175-325g), four loose ligatures of 4-0 chromic gut
were surgically placed around the left sciatic nerve under inhalation
anesthesia as described by Bennet et al (Bennett G J, Xie Y K. Pain 1988,
33(1): 87-107). Seven to 21 days following sciatic chronic constriction
injury (CCl) surgery, the subjects were placed onto a commercial cold
plate device cooled by peltier elements such that the surface temperature
was held at 1° C. Each subject underwent a 6 minute conditioning
period followed by a 3 minute assessment period during which the total
duration of hind paw lifting was recorded. This procedure was repeated at
several intervals prior to and following systemic drug administration.
Test compounds of Formula (I) were assessed for their ability to return
duration of paw lifting back to pre-lesion levels. The duration of paw
lifting during the 3 minute test period following administration of test
compound was taken as a percentage of the duration of paw lifting during
the 3 minute test period prior to test compound treatment. The resultant
data are displayed in Table 11.

[1625] Compounds of Formula (I) can be tested in animal models of pyresis,
according to previously documented and validated methods, such as those
described by Kozak et al (Kozak W, Fraifeld V. Front Biosci 2004, 9:
3339-55). Fever is a frequent accompaniment of inflammatory disease.
Animal models make use of the pyretic properties of yeast and other
inflammatory agents, injecting a yeast suspension or other agent
subcutaneously (Tomazetti J et al. J Neurosci Methods 2005, 147(1):
29-35); Van Miert A S, Van Duin C T. Eur J Pharmacol 1977, 44(3):
197-204). For example, Male Wistar rats (75-100g) can be housed in groups
of four to a cage at controlled temperature (23±1° C.) with a
12 h light:12 h dark cycle (lights on at 07:00 h) and with standard lab
chow and tap water ad libitum. All measured temperatures can be taken
between 08:00 and 19:00 h. Each animal can be used in only one study.
Rectal temperature (TR) can be measured by inserting a lubricated
thermistor probe (external diameter: 3 mm) 2.8 cm into the rectum of the
animal. The probe can be linked to a digital device, which displayed the
temperature at the tip of the probe with a 0.1° C. precision and
logs the values over time.

[1626] Immediately after measuring the initial basal rectal temperature,
the animals can be injected with commercially available dried baker yeast
(Saccharomyces cerevisiae) suspended in pyrogen-free 0.9% NaCl (0.05-0.25
g/kg, i.p.) or 0.9% NaCl (10 ml/kg). TR changes can be recorded every
hour up to 12 h, and expressed as the difference from the basal value.
Since it has been previously reported that handling and temperature
measuring-related stress alter rectal temperature, these animals can be
habituated to the injection and measuring procedure for 2 days before
experiments are carried out. In these sessions, the animals can be
subjected to the same temperature measuring procedure described above,
and can be injected intraperitoneally (i.p.) with 0.9% NaCl (10 ml/kg).

[1627] To assess the effect of potential antipyretic compounds on basal
rectal temperature study animals can have their TR measured for 4 h, and
after the fourth TR measurement they can be subcutaneously (s.c.)
injected with vehicle (such as 10% Solutol in sterile water 5 ml/kg) or a
compound of Formula (I) prepared in vehicle. TR can then be recorded
every hour up to 8 h after the compound injections. To assess the effect
of a compound of Formula (I) on baker yeast-induced hyperthermia, study
animals can have their basal TR measured and then be injected with a
pyrogenic dose of baker yeast (for example, 0.135 g/kg). TR changes can
be recorded every hour up to 4 h, when potential antipyretics agents such
as those of Formula (I) are administered. Rectal temperature can then be
monitored over the following 8 h. Basal rectal temperature and changes in
rectal temperature can be expressed as means±S.E.M. of the differences
from TR at 07:00 h. Data can be analyzed by two-way analysis of variance
(ANOVA), with time of measures treated as within subject factor,
depending on the experimental design. Post hoc analysis can be carried
out by the F-test for simple effect and the Student-Newman-Keuls test,
when appropriate. A value of P<0.05 would be considered statistically
significant.

[1628] The modification of the subsequent pyretic response by therapeutic
agents can also be monitored by rectal telemetry or other measurements of
body temperature. Several clinically relevant agents such as
acetaminophen, aspirin and ibuprofen, reduce fever in these models.

Example 7

CFA-induced Model of Rheumatoid Arthritis

[1629] Compounds of Formula (I) can be tested in animal models of
rheumatoid arthritis, according to previously documented and validated
methods, such as those described by Nagakura et al (Nagakura Y, et al. J
Pharmacol Exp Ther 2003, 306(2): 490-7). For example, arthritis can be
induced by the CFA inoculation in the rats (Male Lewis rats150-225g;
Charles River). Briefly, 100 mg of Mycobacterium butyricum (Difco,
Detroit, Mich.) can be thoroughly mixed with 20 mL of paraffin oil. Then
mixture can be autoclaved for 20 min at 120° C. Each rat can be
injected in the right footpad (hind paw) with the mixture in a 0.1-mL
volume under inhalation anesthesia. The rats serving as controls can be
injected with 0.1 mL of saline. Pain and other disease development
parameters can be measured in the CFA- or saline-treated rats just before
inoculation and up to 28 days post-inoculation. The measurement for pain
parameters can be conducted for both mechanical and thermal (hot or cold)
endpoints. The measurement of mechanical allodynia can be performed using
the von Frey hairs (Semmes-Weinstein Monofilaments, Stoelting Co., IL)
wherein the rats can be habituated to wire mesh bottom cages before the
start of the experiment. Static allodynia can be tested in the
unrestrained rats by touching the plantar surface of the hind paw with
von Frey hairs in ascending order of force (1.2, 1.5, 2.0, 3.6, 5.5, 8.5,
12, 15, 29, and 76g) for up to 6 s or until a paw withdrawal response can
be elicited. The lowest amount of force required to elicit a response can
be recorded as the withdrawal threshold in log g. Thermal hyperalgesia
can be assessed using the radiant heat test wherein a mobile radiant heat
source can be located under a glass surface upon which the rat is placed.
The beam of light can be focused on the hind paw, and the paw withdrawal
latencies are defined as the time taken by the rat to remove its hind paw
from the heat source. The measurement of joint hyperalgesia can be
performed by a modification of the previously reported method (Rupniak N
M J et al. Pain. 1997, 71:89-97). The torso of each rat can be held from
the back with the left palm, and the bending and extension (one after the
other and five times in each direction) of the ankle within its limits of
range of motion can be performed with the right fingers. The total number
of vocalizations emitted after the manipulation (the bending and
extension, five times in each direction) can be recorded for each paw
(the maximum score is 10 for each paw).

[1630] The scoring of mobility can be performed by modifying the
evaluation scale reported by Butler et al. (Butler S H et al 1992 Pain
48:73-81): score 6, walks normally; score 5, walks being protective
toward the ipsilateral hind paw (touches the ipsilateral hind paw fully
on the floor); score 4, walks being protective toward the ipsilateral
hind paw (touches only the toe of the ipsilateral hind paw on the floor);
score 3, walks being protective toward both hind paws (touches the
contralateral hind paw fully on the floor); score 2, walks being
protective toward both hind paws (touches only the toe of the
contralateral hind paw on the floor); scorel, crawls only using the fore
paws; and score 0, does not move. Paw volumes can be measured by volume
displacement of electrolyte solution in a commercially available
plethysmometer device. The hind paw can be immersed to the junction of
the hairy skin, and the volumes can be read on a digital display. The
scoring of joint stiffness can be performed as follows: the body of rats
can be held from the back with the left palm, and the bending and
extension (once in each direction) of the ankle within its limits of
range of motion can be performed with the right fingers. It can be
confirmed beforehand that there is no restriction of ankle joint movement
in the bending and extension manipulations in naive rats, and the scoring
can be performed according to the evaluation scale reported by Butler et
al. (1992): score 2, there are restrictions of full range of movement of
the ankle in both bending and extension; score 1, there is a restriction
of full range of movement of the ankle in bending or extension; and score
0, no restriction. The measurements for paw volume and joint stiffness
can be conducted for both hind paws.

[1631] Compounds of Formula (I) can be assessed for antihyperalgesic
efficacy as follows: thirty-two rats (eight rats per dose and four doses
per compound) that are be treated with the CFA and another eight rats as
naive controls can be used for each drug evaluation. The analgesic
effects can be evaluated on post-inoculation day 9, when mechanical
allodynia, thermal hyperalgesia, joint hyperalgesia, and joint stiffness
in the ipsilateral paw reached almost the maximum, although those
parameters in the contralateral paw changed only slightly and the
systemic disturbance shown by the change of mobility score is small. On
the day before evaluation, body weight, mechanical allodynia, thermal
hyperalgesia, and joint hyperalgesia can be measured for the 32 rats that
are to be used for compound evaluation. The rats are allocated to four
groups (eight rats per group) such that the differences in the averages
of those parameters among the groups became small. All the analgesic
effect evaluations and behavioral observations can be carried out by the
observer who is blind to the drug treatment.

[1632] Data can be expressed as the mean+/-S.E.M. The time-course curves
for mechanical allodynia, thermal hyperalgesia, joint hyperalgesia, body
weight, and paw volume can be subjected to two-way repeated measures
analysis of variance with post hoc t test. In experiments for evaluation
of a compound of Formula (I), the difference in scores between the
vehicle-treated and naive control groups can be analyzed by Student's t
test to confirm significant changes in the pain parameters in the
ipsilateral paw. The analgesic effects can be analyzed by Dunnett's t
test, and in each case the drug-treated groups can be compared with the
vehicle-treated group. In each statistical analysis, the comparison can
be conducted for paws on the corresponding side. P<0.05 is considered
statistically significant.

Example 8

In Vivo Model for Arthritis: Inflammogen-induced Hyperalgesia of the Knee
Joint

[1633] Compounds of Formula (I) can be tested in animal models of
osteoarthritis, according to previously documented and validated methods,
such as those described by Sluka et al (Sluka K A, Westlund K N. Pain
1993, 55(3): 367-77). For example, male Sprague-Dawley rats (Harlan,
Indianapolis, Ind.) weighing 225 to 350g can be briefly anesthetized with
vaporized halothane and then injected with a mixture of 3% carrageenan
and 3% kaolin (100 μL in 0.9% sterile saline) into the joint cavity of
one knee. After the injection, the animals can be returned to their cages
until the time of testing. For behavioral testing animals can be placed
in individual clear plastic cages on top of an elevated wire mesh surface
that restricted movement. The animals should be allowed to acclimate for
approximately 1 hour before testing. Von Frey filaments, as described
above, can then be used to test for enhanced responses to mechanical
stimuli. The filaments can be successively applied through the wire mesh
perpendicularly to the plantar surface in between the pads of the third
and fourth phalanges. The response threshold to mechanical stimuli can be
determined before inflammation of the knee joint; 4 hours after
inflammation to confirm the development of hyperalgesia; immediately
after the administration of test compound such as those of Formula (I)
i.e. 5 hours after inflammation; and at 8, 12, and 24 hours after
inflammation.

[1634] The Kruskal-Wallis test, a nonparametric test, can be used to
analyze the effects for frequency, intensity, and group for response to
mechanical stimuli at baseline, 4 hours after inflammation, and after
compound treatment (5 hours, 8 hours, 12 hours, and 24 hours after
inflammation). Further post hoc testing between groups can be executed by
using the Mann-Whitney signed rank test. The data can be presented as
median with 25th and 75th percentiles. Significance is P≦0.05.

[1635] Additionally, the gait of the animal or other pain-related behavior
can be scored as the dependent measure of the painful effect of the
arthritis on the animal's activity (Hallas B, Lehman S, Bosak A, et al. J
Am Osteopath Assoc 1997, 97(4): 207-14). The effect of test drug on the
animal's normal behavior can be quantified from zero, meaning no
response, to three for incapacitating impairment. Effective analgesic
treatment includes the clinically used indomethacin (Motta A F, et al.
Life Sci 2003, 73(15): 1995-2004).

Example 9

Sarcoma Cell-induced Models of Bone Cancer Pain

[1636] Compounds of Formula (I) can be tested in animal models of bone
cancer pain, according to previously documented and validated methods,
such as those described in the scientific literature (E1 Mouedden M,
Meert T F. Pharmacol Biochem Behav 2005, 82(1): 109-19; Ghilardi J R, et
al. J Neurosci 2005, 25(12): 3126-31). In preparation for cell
inoculation and tumor induction, osteolytic murine sarcoma cells (NCTC
2472, American Type Culture Collection (ATCC), Rockville, Md., USA) can
be cultured in NCTC 135 medium (Invitrogen) containing 10% horse serum
(Gibco) and passaged 2 times weekly according to ATCC guidelines. For
their administration, cells can be detached by scraping and then
centrifuged at 1000×g. The pellet can be suspended in fresh NCTC
135 medium (2.5×106 cells/20 μL) and then used for
intramedullary femur inoculation. Male C3H/HeNCrI mice (25-30g, Charles
River Labs) can be used in such experiments. After induction of general
anesthesia with xylazine (10 mg/kg i.p.) and ketamine (100 mg/kg i.p.)
the left hind paw can be shaved and disinfected with povidone-iodine
followed by 70% ethanol. A superficial incision of 1 cm can then be made
over the knee overlaying the patella. The patellar ligament can then be
cut, exposing the condyles of the distal femur. A 23-gauge needle can be
inserted at the level of the intercondylar notch and the intramedullary
canal of the femur to create a cavity for injection of the cells. Twenty
microliters of media (sham animals) or media containing tumor cells
(approximately 2.5×106 cells) can then be injected into the
bone cavity using a syringe. To prevent leakage of cells outside the
bone, the injection site can be sealed with dental acrylic and the wound
closed with skin stitches.

[1637] Pain behaviors can be evaluated in separate groups (n=6) of sham
and bone tumor mice with confirmed hyperalgesia as assessed by
spontaneous lifting behavior. Animals can be behaviorally tested during a
3-week period prior to and after tumor inoculation. Body weight of the
mice can be recorded throughout the experimental period to help monitor
general health status. To measure the spontaneous lifting, the animals
can be habituated in a transparent acrylic cylinder of 20 cm diameter put
on an horizontal surface and thereafter observed during 4 min for
spontaneous lifting behavior of the left hind paw. After spontaneous
lifting behavior assessment, animals can be immediately placed on a mouse
rotarod (e.g. ENV-575M\, Med Associates Inc., GA, USA) at a speed of 16
rpm for 2 min wherein limb-use during forced ambulation is scored:
4=normal; 3=limping; 2=partial non-use of left hind paw; 1=substantial
non-use of left hind paw; 0=non-use of left hind paw. Assessment of cold
allodynia may be made by exposing the ipsilateral hind paw of the mouse
to 5 repeated applications of acetone (20 μL) and quantifying the
lift/licking frequency and/or duration. Post-mortem evaluation of bone
destruction can be assessed by ACT processing followed by scanning using
a system such as the Skyscan 1076 microtomograph system for small animal
imaging (Skyscan 1076\, Skyscan, Aartselaar, Belgium). Measured
histomorphometry parameters of bone destruction can be subsequently
correlated with behavioral endpoints.

[1638] The antihyperalgesic, antiallodynic and disease modifying effects
of compounds such as those of Formula (I) can be tested in this murine
model of bone cancer pain in separate groups (n=6 per dose group).
Animals with confirmed hyperalgesia, as assessed by spontaneous or
acetone-evoked lifting, can be behaviorally tested, for example, on days
15 and 22 after distal femur tumor inoculation before and 1 h after
systemic administration of vehicle (e.g. 10% Solutol in sterile water) or
a compound of Formula (I). The statistical analysis can be performed by
one-way ANOVA to compare behavioral measurements and bone parameters
among the experimental groups. To compare behavioral measurements and
bone parameters between sham and tumor-bearing animals, a Mann-Whitney U
test can be used. Results are considered statistically significant at
P<0.05 (two-tailed). Data are expressed as mean+/-S.E.M.

[1640] Compounds of Formula (I) can be tested in animal models of
antitussive activity, according to previously documented and validated
methods, such as those described by: Tanaka, M. and Maruyama, K. J.
Pharmacol. Sci. 2005, 99(1), 77-82; Trevisani, M. et al., Throax 2004,
59(9), 769-72; and Hall, E. et al., J. Med. Microbiol. 1999, 48: 95-98.
Testing is conducted in transparent ventilated chambers with a constant
airflow of 400 mL/min. The tussive agent (citric acid 0.25 M or capsaicin
30 mM) can be nebulised via a miniultrasonic nebuliser with an output of
0.4 mL/min. The appearance of cough can be detected by means of a tie
clip microphone and confirmed by the characteristic posture of the
animal. The cough sounds can be recorded and digitally stored. A blinded
observer subsequently counts the number of elicited cough efforts. In
some cases, animals can be sensitized by pre-exposure to certain agents
such as ovalbumin. A test compound can be administered to at the peak of
irritant-induced cough to evaluate the antitussive effects of the
compound. In addition, prophylactic or multiple dosing regimes can be
utilized to evaluate the test compound for modulation of the onset and
duration of irritant-induced cough. Variations of these tests predict the
antitussive effects of effective clinical agents, including NMDA
antagonists such as dextrorphan and dextromethorphan, opioids such as
codeine, beta 2 agonists such as salbutamol and antimuscarinics such as
ipratropium (Bolser, D. C. et al., Eur. J. Pharmacol. 1995, 277(2-3),
159-64; Braga, P.C. Drugs Exper. Clin. Res. 1994, 20, 199-203).

[1641] Compounds of Formula (I) can be tested in animal models of contact
dermatitis or itch, according to previously documented and validated
methods, such as those described in the scientific literature
(Saint-Mezard P et al. Eur J Dermatol. 2004, 14(5): 284-95; Thomsen J.
S., et al. J. Exp Dermatol. 2002, 11(4): 370-5; Weisshaar E, et al. Arch
Dermatol Res 1998, 290(6): 306-11; Wille J J, et al. Skin Pharmacol Appl
Skin Physiol. 1999, 12(1-2): 18-27). Mice (or species such as guinea pig
or rat) can be sensitized with 25 mL of 0.5% dinitrofluorobenzene
solution (DNFB diluted 4:1 in acetone:olive oil immediately before
application or other haptens, such as 12-myristate-13 acetate, picryl
chloride, oxazolone, capsaicin, arachidonic acid, lactic acid,
trans-retinoic acid or sodium lauryl sulfate) painted to the shaved
dorsal skin or untreated (controls). Five days later, 10 mL of 0.2% DNFB
a nonirritant dose) can be applied onto both sides of the right ear and
the same amount of solvent alone onto the left ear. Ear thickness can be
monitored daily using a caliper. Compounds of Formula (I) can be
administered at the peak of inflammation to evaluate the anti-allergy
activity of compounds. In addition, prophylactic or multiple dosing
regimes can be utilized to evaluate the test compound for modulation of
the onset and duration of anti-allergy activity. Variations of these
tests can predict the anti-allergy and itch activity of effective
clinical agents. The ability of these models to predict the therapeutic
effect of compounds in human dermal conditions is supported by the
cross-species ability of serotonin to induce itch (Weisshaar E, Gollnick
H. Skin Therapy Lett 2000, 5(5): 1-2,5). Additionally, for the contact
sensitizing property of commercially important drugs and the ability of
ion channel modulators to prevent and treat skin sensitization in these
models, see Kydonieus A, et al., Proceedings of the International
Symposium on Controlled Release of Bioactive Materials 24th:23-24, 1997.

Example 12

Chemical Irritant-induced Models of Rhinitis and Other Manifestations of
Nasal Hypersensitivity and/or Inflammation

[1642] Compounds of Formula (I) can be tested in animal models of
rhinitis, according to previously documented and validated methods, such
as those described in the scientific literature (Hirayama Y, et al. Eur
J. Pharmacol. 2003, 467(1-3): 197-203; Magyar T, et al. Vaccine 2002,
20(13-14): 1797-802; Tiniakov R L, et al. J Appl Physiol 2003, 94(5):
1821-8). Testing can be conducted in mouse, guinea pig, dog or human in
response to intranasal challenge with one or more irritants such as cold
air, capsaicin, bradykinin, histamine, pollens, dextran sulfate,
2,4-tolylene diisocyanate, Bordetella bronchiseptica, Pasteurella
multodica or acetic acid. In some cases, animals can be sensitized by
pre-exposure to certain agents including, but not limited to, ragweed or
ovalbumin. Prior to or following irritant administration, the test
subject can receive, respectively, the prophylactic or therapeutic
administration one or more times of a compound of Formula (I), or vehicle
control, by the enteral or parenteral route. Significant differences
indicative of nasal rhinitis or sensitization for the test
compound-treated subjects compared with vehicle-treated subjects can be
taken as evidence of anti-rhinitis activity. Independent variables
include dose, frequency and route of administration, time interval
between prophylactic or therapeutic test compound administration and
irritant challenge as well as sex and non-sex genotype of the test
subject.

Example 13

Conflict-induced Models of Anxiety, Panic Disorder and Other Non-adaptive
Stressful or Phobic Responses

[1643] Compounds of Formula (I) can be tested in animal models of anxiety,
panic disorders and other non-adaptive responses, according to previously
documented and validated methods, such as those described by Cryan and
Holmes (Cryan J F, Holmes A. Nat Rev Drug Discov 2005, 4(9): 775-90) or
Braw et. al. (Y. Braw et al. Behavioural Brain Research 2006, 167:
261-269). Specifically, for studies in rats, the following apparati may
be utilized: an open-field arena (62 cm×62 cm) enclosed by opaque
walls (30 cm high) and plus-maze consists of two open arms, 50
cm×10 cm, and two enclosed arms, 50 cm×10 cm×40 cm with
an open roof, arranged such that the two arms of each type are opposite
each other. The maze is elevated to a height of 70 cm. The walls of the
enclosed arms are made from black Plexiglas, while the floors from white
Plexiglas. Videotape recordings can be analyzed using the `Observer`
system (Noldus Information Technology). A subject rat can be removed from
its home cage, weighed and placed gently in the center of the open-field
arena. The rat can be allowed to explore the open-field freely while its
behavior is videotaped for 5 min. Afterwards, it can be transferred to
the plus-maze and placed at the center, facing a closed arm. The rat's
behavior can again be videotaped for 5 min, after which it can be
returned to its home cage. The apparatus can cleaned using a 70% ethanol
solution between rats.

[1644] Open-field and plus-maze measures can be grouped into two
behavioral classes, namely `anxiety-like behaviors` and `activity`.
Open-field behavioral measures may include 1) Anxiety measures: % time in
center square, % number of entries to center square (from total squares
entered), % time freezing, latency to first freezing (freezing is scored
when the subject is in an immobile state for at least 3 seconds; and 2)
Activity measures: Total squares entered, number of rearings (standing on
two hind legs), latency for first rearing. Plus-maze measures may include
1) Anxiety: % time in open arms, % number of entries to open arms (from
total entries), number of unprotected head dips, latency to enter open
arm; and 2) Activity: Total entries to all arms. Anxiety-like behaviors
and activity can be analyzed by one-way ANOVA's on each of the measures,
for each the between-subject comparisons. Plus-maze analyses can be
conducted in a similar fashion.

[1645] Testing may also be conducted in mouse or rat in this fashion in
order to measure avoidance of other aversive environmental stimuli such
as Geller or Vogel anticonflict tests, the light/dark test and the
hole-board test (see Cryan J F, Holmes A. Nat Rev Drug Discov 2005, 4(9):
775-90). Prior to environmental exposure, the test subject can receive
the prophylactic administration one or more times of a compound of
Formula (I), or vehicle control (e.g. 10% Solutol in sterile water), by
the enteral or parenteral route. The cumulative time or number of times
spent engaged in the aversive behavior can be measured. Significant
differences in one or more of these measures for the test
compound-treated subjects compared with vehicle-treated subjects can be
taken as evidence of anxiolytic activity. These models are
pharmacologically validated by the effectiveness of clinically useful
anxiolytics (Cryan J F, Holmes A. Nat Rev Drug Discov 2005, 4(9):
775-90).

[1646] Compounds of Formula (I) can be tested in animal models of urinary
incontinence according to previously documented and validated methods,
such as those described by in the scientific literature (Kaiser S, Plath
T, (Metagen Pharmaceuticals GmbH, Germany). 2003 De patent 10215321.;
McMurray G, et al. Br J Pharmacol 2006, 147 Suppl 2: S62-79). TRPM8 is
expressed in human prostate, testicle, seminiferous tubules, scrotal skin
and inflamed bladder (Stein R J, et al. J Urol. 2004, 172(3): 1175-8);
(Stein R J, et al. J Urol. 2004, 172(3): 1175-8; Mukerji et al. BMC
Urology 2006, 6:6). Excitation of TRPM8 receptors through cooling or
application of menthol causes contraction in the bladder and a decrease
in micturation threshold volume (Tsukimi Y, Mizuyachi K, et al. Urology.
2005, 65(2): 406-10). To assess compounds of Formula (I) for potential
urinary incontinence activity, Sprague-Dawley rats are surgically
implanted with bladder catheters allowing for the delivery of fluid
(typically saline) and the monitoring of pressure (using a pressure
transducer). Cystometry recordings can be monitored with a polygraph to
evaluate voiding interval, threshold pressure, bladder capacity, bladder
compliance, and the number of spontaneous bladder contractions. For
example, the bladder catheter can be connected to a Harvard infusion
pump, and bladders perfused overnight with saline at 2 mL/h. The next
morning the bladder catheter can be attached (using a "T" connector) to a
Statham pressure transducer (Model P23 Db) and to a Harvard infusion
pump. A plastic beaker attached to a force displacement transducer (Grass
FTO3) can be placed under the rat's cage to collect and record urine
volume. The cystometric evaluation of bladder function can be started by
infusing saline (20 mL/h) and after the first micturition the infusion is
maintained for 20 min. Two hours after the first cystometry period, the
rats can be dosed orally with a test compound of Formula (I) and a second
cystometry is performed between 30 min and 4 h after administration of
test compound. The appropriate vehicle (e.g. 10% Solutol in sterile
water) can be similarly administered to groups of rats that served as
controls and the cystometry can be performed at the same respective time
points.

[1647] The compounds of the present invention can also be evaluated under
conditions of bladder hypertrophy and instability. Under anesthesia, a
silk ligature is tied around the proximal urethra of rodents producing a
partial outlet obstruction and subsequent hypertrophied bladder
development within 6-9 weeks (Woods M. et al., J. Urology. 2001,
166:1142-47). Cystometry recordings can then be evaluated as described
above. Such preclinical procedures are sensitive to compounds having
clinical utility for the treatment of urinary incontinence (Soulard C, et
al. J Pharmacol Exp Ther 1992, 260(3): 1152-8).

Example 15

In Vivo Model for Cold-enhanced Central Pain States

[1648] Injury to the brain or spinal cord, such as that caused by trauma,
interrupted blood flow or neurodegenerative diseases, often precipitates
a central pain condition. Examples of such injuries characterized, in
part by, a hypersensitivity to cold stimuli include multiple sclerosis
(Morin C, et al. Clin J Pain. 2002, 18(3): 191-5; Svendsen K B, et al.
Pain. 2005, 114(3): 473-81), stroke or cerebral ischemia (Greenspan J D,
et al. Pain. 2004, 109(3): 357-66) and spinal cord injury (Defrin R, Ohry
A, Blumen N, Urca G. Pain 2001, 89(2-3): 253-63; Defrin R, et al. Brain
2002, 125(Pt 3): 501-10; Finnerup N B, et al. Anesthesiology 2005,
102(5): 1023-30). Each of these conditions may be readily modeled in
animals for assessment of the abililty of compounds of Formula (I) to
mollify the hypersensitive state. For example, a spinal cord injury (SCI)
can be performed in adult Sprague-Dawley rats having a body weight of
150-200g at time of surgery (Erichsen et al. Pain 2005, 116: 347-358).
The rats can be anaesthetized with chloral hydrate (300 mg/kg, i.p.,
Sigma, USA) and a catheter can be inserted into the jugular vein. A
midline skin incision can then be made along the back to expose the
T11-L2 vertebrae. The animals can be positioned beneath a tunable argon
ion laser (Innova model 70, Coherent Laser Products Division, Calif.,
USA) operating at a wavelength of 514 nm with an average power of 0.17 W.
The laser light can be focused into a thin beam covering the single T13
vertebra, which can be irradiated for 10 min. Immediately before the
irradiation, erythrosin B (Aldrich, 32.5 mg/kg dissolved in 0.9% saline)
can be injected intravenously via the jugular catheter. Due to rapid
metabolism of erythrosin B, the injection can be repeated after 5 min in
order to maintain adequate blood concentrations. During irradiation, the
body core temperature can be maintained at 37-38° C. by a heating
pad. After irradiation the wound can be closed in layers and the skin
sutured together.

[1649] SCI rats can be routinely tested for the presence of pain-like
behaviors from 3-4 weeks after surgery. The fur of the animals can be
shaved at least a day prior to examination of the cutaneous pain
threshold to avoid sensitization of the skin receptors. During testing,
the rats can be gently held in a standing position by the experimenter
and the flank area and hindlimbs can be examined for hypersensitivity to
sensory stimulation. On the day of drug testing, SCI rats can be
administered drug according to the experimental schedule and the time
course of pain-like behaviors can be measured. To test for the presence
of cold allodynia, ethyl chloride or acetone can be sprayed onto the skin
of the animals, often that which has been previously determined to be
sensitive to mechanical stimulation by von Fry filament testing. The
subsequent response to cold stimulation can be observed and classified
according to the following scale: 0, no visible response; 1, localized
response (skin twitch) without vocalization; 2, transient vocalization;
3, sustained vocalization. Kruskal Wallis ANOVA on ranks can be used to
analyze the overall effects of non-parametric data obtained in response
to cold stimulation following pretreatment with either a compound of
Formula (I) or vehicle.

Example 16

In Vivo Model for Post-anesthetic Shivering

[1650] Spontaneous post-anesthetic tremor that resembles shivering is
common during recovery from anesthesia. Risks to postoperative patients
include an increase in metabolic rate of up to 400%, hypoxemia, wound
dehiscence, dental damage, and disruption of delicate surgical repairs.
The etiology of spontaneous post-anesthetic tremor is most commonly
attributed to normal thermoregulatory shivering in response to
intraoperative hypothermia. In most operating and recovery rooms,
shivering is controlled by the use of humidifiers, warming blankets, and
inhalation of humidified heated oxygen. However, pharmacological control
is an effective alternate treatment modality (Bhatnagar S, et al. Anaesth
Intensive Care 2001, 29(2): 149-54; Tsai Y C, Chu K S. Anesth Analg 2001,
93(5): 1288-92). Compounds of Formula (I) may be assessed for their
ability to mitigate post-ansethetic induced-shaking by using animal
models such as that described by Nikki et al (Nikki P, Tammisto T. Acta
Anaesthesiol Scand 1968, 12(3): 125-34 and Grahn (Grahn, D A, et al. J
Applied Physiology. 1996, 81: 2547-2554). For example, Wistar rats
(males, weighing 250-450g;) may be surgically implanted with an EEG/EMG
recording array to assess post anesthetic tremor activity. The EEG
electrodes are located bilaterally 2 mm off midline and adjacent to
bregma and lamda. Following a one-week recovery period, frontal-occipital
EEG, raw EMG, and integrated EMG activities, as well as three
temperatures (skin, rectal, and water blanket temperatures during
anesthesia), and ambient temperature post-anesthesia can be monitored
throughout the experiment using copper-constantin thermocouples. The EEG
and EMG signals can be recorded on polygraph paper (5 mm/s, Grass model
7E polygraph) and, during recovery from anesthesia, the EEG is computer
scored in 10 second epochs as either synchronized: high amplitude (0.100
pV), low frequency (1-4 Hz dominated) activity characteristic of
slow-wave sleep (SWS-like) or desynchronized: low amplitude (75 μV),
high frequency (5-15 Hz dominated), characteristic of waking and
rapid-eye-movement sleep (W-like). The EMG activity can be quantified as
the averaged summed voltage/time interval by processing the raw EMG
signal through an integrator (Grass model 7P3, 0.5 s time constant). On
the day of an experiment, the animal can be placed in a small acrylic box
(15×15×15 cm) and exposed to a halothane vapor-air mixture
(4% halothane). Immediately after the induction of anesthesia, the animal
can be removed from the enclosure and subsequently anesthetized through a
nose cone. Following cessation of anesthesia, two stages of recovery can
be judged: emergence from anesthesia and restoration of behavioral
activity (behavioral recovery). Emergence from anesthesia may be defined
as an increase in tonic EMG activity and a change in the EEG from a
SWS-like pattern to a W-like pattern. Behaviorally, recovery has occurred
when the animal rises from a prone position and initiated coordinated
movements. The time intervals from termination of anesthesia to emergence
and behavioral recovery can be measured in all animals. Time interval
data can be subjected to a repeated measure analysis of variance, and the
Scheffe's method can be employed for testing differences between pairs of
means.

[1653] In experiments where temperatures were varied, temperature ramps
were generated by cooling the perfusate in an in-line cooler (Model
SC-20, Warner Instruments, Hamden, Conn.) controlled by a temperature
controller (Model CL-100, Warner Instruments). The temperature in the
vicinity of the recorded cell was measured with a custom-made miniature
thermo-microprobe connected to a monitoring thermometer (Model TH-8,
Physitemp, Clifton, N.J.), and sampled using Digidata 1322A and pClamp
9.0 (Molecular Devices), as were the currents concurrently measured in
the whole-cell patch clamp mode. The current was continuously sampled (at
100 Hz) at a holding potential of -60 mV.

[1654] Compounds were diluted from 10 mM DMSO stocks (stored at
-20° C.) into an extracellular solution either containing 100
μM menthol or subjecting to cooling. Increasing concentrations of a
compound were applied to a cell in a cumulative manner and
concentration-dependent responses were measured after steady-state
activation was achieved by either 100 μM menthol or cooling to
10° C. A saturating concentration of a reference antagonist was
applied at the end of an experiment (either in the presence of 100 μM
menthol or 10° C. temperature) to establish the baseline from
which all the other measurements were subtracted.

[1655] Percentage inhibition by a compound was calculated as follows:
100×(1-Icomp/I0); where Icomp and I0 are
steady-state current amplitudes in either the presence or absence of a
concentration of the compound. Concentration-response data were fitted to
a logistic function as follows: R=100/(1+c/IC50)p; where, R is
the percentage inhibition, p is the Hill coefficient and c is the
concentration of the test compound. The resultant data are displayed in
Table 11.

[1656] For functional expression of TRPM8, the full-length cDNAs encoding
human and rat TRPM8 were subcloned into pCI-NEO mammalian expression
vectors. The expression constructs were transiently transfected into
HEK293 cells according to the FuGENE 6 transfection Reagent® (ROCHE)
instructions. HEK293 cells were routinely grown as monolayers in
Dulbecco's minimum essential medium supplemented with 10% FBS, 1 mM
L-glutamine, 100 units/mL penicillin and 100 ug/mL streptomycin. Cells
were maintained in 5% CO2 at 37° C. Within twenty-four hours,
transiently transfected human and rat TRPM8 were seeded into clear-base
poly-D-lysine coated 384-well plates (BD Biosciences, NJ, USA) at a
density of 10,000 cells per well in culture medium and grown overnight.
The following day, all medium was removed and the cells were incubated
with 52 μL of 0.5×calcium 3 dye (Molecular Devices) prepared in
complete assay buffer containing 20 mM HEPES, 0.1% BSA, and 2.5 mM
probenecid at 37° C. for thirty five minutes. The cells were then
incubated for an additional fifteen minutes at room temperature before
initiating experiments. Following incubation, plates were inserted into a
FDSS instrument, where cells were challenged with a compound of Formula
(I) (at varying concentrations) and intracellular Ca2+was measured
for 5 min prior to the addition of 100 nM icilin. IC50 values for
compounds of the present invention were determined from eight-point
dose-response studies

[1657] Maximal fluorescence intensity (FI) achieved upon addition of
icilin was exported from the FDSS and further analyzed using Graph Pad
Prism 3.02 (Graph Pad Software Inc., CA, U.S.A.). Basal FI was subtracted
prior to normalizing data to percent of maximal response. The dose
response curves from the average of quadruplicate wells for each data
point were analyzed by using nonlinear regression of either sigmoidal
dose response or sigmoidal dose response (variable slope). Finally, the
IC50 values were calculated with the best-fit dose curve determined
by Prism. The resultant data are displayed in Table 12.

[1658] Compounds of Formula (I) can be tested in animals and humans for
their ability to mitigate cardiovascular pressor responses evoked by cold
exposure. The clinical cold pressor test assesses changes in blood
pressure (BP) and cold pain perception during a 2-3 minute immersion of
one hand into ice water. This test may be utilized to characterize
analgesic compounds (Koltzenberg M et al. Pain. 2006, 126(1-3): 165-74)
and to assess cold hypersensitivity (Desmeules J A et al. Arthritis
Rheum. 2003, 48(5): 1420-9). A compound of Formula (I) was studied in an
anesthetized rat cold pressor paradigm to determine whether TRPM8
antagonism would interfere with the blood pressure pressor response to
cold stimulation of the forepaws. Male Sprague-Dawley rats (300-450 g)
anesthetized with sodium pentobarbital were instrumented with a jugular
catheter and an indwelling carotid artery pressure transducer. Vehicle
(10% Solutol in water) or test compound was infused (1 mL/kg) over one
minute through the intravenous catheter. Ten minutes later both forelimbs
were packed in crushed ice for 5 minutes. Percent changes in mean
arterial pressure in response to this cold stimulus were calculated for
vehicle and test compound pretreatments. Percent inhibition attributed to
treatment with test compound was then determined using the following
formula: % Inhibition=[1-(cold evoked % change in BP post-test
compound/cold evoked % change in BP post-vehicle)]×100. The
resultant data are displayed in Table 13.

[1659] While the foregoing specification teaches the principles of the
present invention, with examples provided for the purpose of
illustration, it will be understood that the practice of the invention
encompasses all of the usual variations, adaptations and/or modifications
as come within the scope of the following claims and their equivalents.