‘Supreme’ ... a first edition of Charles Darwin’s landmark book, in front of a portrait of Darwin at a 2010 exhibition celebrating The Royal Society.
Photograph: Martin Godwin for the Guardian

Charles Darwin’s On the Origin of Species has been voted the most influential academic book ever written, hailed as “the supreme demonstration of why academic books matter” and “a book which has changed the way we think about everything”.

After a list of the top 20 academic books was pulled together by expert academic booksellers, librarians and publishers to mark the inaugural Academic Book Week, the public was asked to vote on what they believed to be the most influential. With titles in the running including A Vindication of the Rights of Woman by Mary Wollstonecraft, George Orwell’s novel Nineteen Eighty-Four, and Adam Smith’s The Wealth of Nations, Darwin’s explanation of his theory of evolution was the public’s overwhelming favourite, with 26% of the vote, said organisers.

Professor Andrew Prescott of the University of Glasgow called Darwin’s 1859 study “the supreme demonstration of why academic books matter”. “Darwin used meticulous observation of the world around us, combined with protracted and profound reflection, to create a book which has changed the way we think about everything – not only the natural world, but religion, history and society,” he said. “Every researcher, no matter whether they are writing books, creating digital products or producing artworks, aspires to produce something as significant in the history of thought as Origin of Species.”

On the Origin of Species was followed in the public vote by The Communist Manifesto and The Complete Works of Shakespeare, with Plato’s The Republic fourth, and Immanuel Kant’s Critique of Pure Reason fifth - a choice heralded by the Booksellers Association’s Alan Staton. “We seem to be governed by expediency and doublethink and it’s reassuring to know that Kant’s Categorical Imperative is known and thought important,” he said.

Philosopher Roger Scruton agreed. “I am gratified that the Critique of Pure Reason, which must be surely one of the most difficult works of philosophy ever written, should have been chosen as among the most influential of all academic books,” he said of the 18th-century text.

“Kant set out on an extraordinary task, which was to show the limits of human reasoning, and at the same time to justify the use of our intellectual powers within those limits. The resulting vision, of self-conscious beings enfolded within a one-sided boundary, but always pressing against it, hungry for the inaccessible beyond, has haunted me, as it has haunted many others since Kant first expressed it.”