Body composition changes with time in pediatric burn patients

Short Title:

Model System:

Burn

Reference Type:

Journal Article

Accession No.:

Journal:

J. Trauma

Year, Volume, Issue, Page(s):

2006, vol. 60, issue 5, pp 968-971

Publication Website:

Abstract:

Background: Major trauma and burns are associated with whole body catabolism which can persist for 1 or more years after injury. This study investigates body composition in massively burned children for up to 2 years.
Methods: Twenty-five pediatric patients with greater than 40% total body surface area burns were studied. At discharge, 6, 12, 18, and 24 months after burn height, weight, body composition, resting energy expenditure (REE), serum growth hormone, insulin-like growth factor-I (IGF-I), IGF binding protein-3 (IGFBP-3), insulin, cortisol, parathyroid hormone, and thyroid hormones were measured. Tukey's test was used for analysis. Significance was accepted at p < 0.05.
Results: Lean body mass, fat mass, bone mineral content, height, and weight increased significantly during the second year after burn. Percent predicted REE decreased significantly, whereas IGFBP-3 and parathyroid hormone levels increased significantly over time. Insulin and T3 uptake were significantly higher at discharge.
Conclusions: Body composition of severely burned children significantly improved in the second year compared with the first year after injury. This demonstrates a need for long-term rehabilitation in these burn patients.

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About MSKTC

The MSKTC is a national center that helps facilitate the knowledge translation process to make research meaningful to those with spinal cord injury (SCI), traumatic brain injury (TBI) and burn injury (Burn).

MSKTC Funding

The MSKTC is funded by the National Institute on Disability, Independent Living, and Rehabilitation Research (NIDILRR) and is operated by the American Institutes for Research (AIR) under grant number 90DP0012.

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