Charterhouse Street is perhaps most famous for its gastropubs, such as the Fox and Anchor, that attract local City workers and is a popular venue for revellers, with Fabric nightclub located at No. 77A. The street was the home of several cold stores serving Smithfield Meat Market including the Central Cold Store and the Metropolitan Cold Stores at 77A.

Charterhouse Street is also the home of a 31 MWe combined heat and power plant operated by Citigen[1] (E.ON) and located within and beneath the former Port of London Authority's Smithfield cold storage facility.[2]

The site on the corner of Farringdon Road was occupied by the 1960s Caxton House which was demolished in 2009 as part of the Farringdon station extension. [3]