GREMLIN Results:
Residue pairs sorted by strength in covariance:Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

i

j

Raw Score

Scaled Score

128_F

180_A

0.29779

3.069

140_A

160_N

0.21974

2.265

74_G

131_L

0.17789

1.833

181_G

185_A

0.17295

1.782

133_V

164_L

0.17064

1.759

70_A

134_A

0.16406

1.691

74_G

134_A

0.15708

1.619

167_T

172_Q

0.15574

1.605

164_L

167_T

0.15364

1.583

133_V

167_T

0.1529

1.576

182_A

186_L

0.15096

1.556

86_P

127_A

0.15002

1.546

137_V

182_A

0.14984

1.544

125_V

131_L

0.14869

1.532

85_P

172_Q

0.14736

1.519

77_I

184_L

0.14407

1.485

133_V

178_V

0.14311

1.475

140_A

157_L

0.14204

1.464

150_R

155_L

0.14129

1.456

154_A

158_A

0.13274

1.368

140_A

156_F

0.13118

1.352

168_V

175_V

0.12796

1.319

150_R

187_L

0.12786

1.318

126_A

172_Q

0.12613

1.300

88_F

178_V

0.1253

1.291

20_Q

126_A

0.12448

1.283

167_T

178_V

0.12216

1.259

131_L

134_A

0.11918

1.228

78_Y

184_L

0.11841

1.220

51_L

175_V

0.11514

1.187

47_V

139_C

0.1151

1.186

104_G

107_F

0.11462

1.181

84_A

127_A

0.11406

1.175

18_S

80_L

0.1135

1.170

180_A

183_A

0.11308

1.165

71_L

75_F

0.11268

1.161

20_Q

24_A

0.11214

1.156

20_Q

25_S

0.11167

1.151

155_L

187_L

0.1116

1.150

87_R

124_G

0.11152

1.149

61_R

74_G

0.11113

1.145

59_R

157_L

0.10995

1.133

37_Y

60_F

0.10699

1.103

78_Y

127_A

0.10522

1.084

137_V

160_N

0.10521

1.084

85_P

126_A

0.10504

1.083

85_P

127_A

0.1049

1.081

33_L

165_F

0.10457

1.078

156_F

161_V

0.1037

1.069

59_R

73_I

0.10342

1.066

127_A

168_V

0.10323

1.064

78_Y

126_A

0.10305

1.062

144_W

153_R

0.10264

1.058

76_V

158_A

0.10218

1.053

68_L

79_I

0.10201

1.051

85_P

167_T

0.10196

1.051

28_W

153_R

0.10181

1.049

108_F

112_A

0.10053

1.036

67_L

135_W

0.10028

1.033

71_L

131_L

0.10024

1.033

43_Q

160_N

0.10014

1.032

151_W

154_A

0.10005

1.031

73_I

76_V

0.09948

1.025

48_V

73_I

0.09929

1.023

44_V

150_R

0.09925

1.023

83_A

133_V

0.09859

1.016

64_F

67_L

0.09833

1.013

126_A

131_L

0.09808

1.011

85_P

175_V

0.0979

1.009

157_L

182_A

0.09753

1.005

23_L

169_Y

0.09749

1.005

68_L

182_A

0.09717

1.001

83_A

167_T

0.09653

0.995

85_P

125_V

0.09651

0.995

102_V

105_G

0.0961

0.990

43_Q

181_G

0.09609

0.990

24_A

28_W

0.09599

0.989

82_P

126_A

0.09589

0.988

87_R

172_Q

0.09569

0.986

165_F

169_Y

0.09516

0.981

133_V

182_A

0.09476

0.977

69_L

76_V

0.09434

0.972

40_F

43_Q

0.0942

0.971

40_F

174_Y

0.09371

0.966

124_G

172_Q

0.09349

0.963

78_Y

86_P

0.09347

0.963

101_P

158_A

0.09321

0.961

156_F

160_N

0.09288

0.957

46_F

49_L

0.09287

0.957

55_R

67_L

0.09272

0.956

71_L

135_W

0.0927

0.955

85_P

123_N

0.0926

0.954

35_F

181_G

0.09254

0.954

41_F

125_V

0.09234

0.952

58_D

186_L

0.09179

0.946

28_W

58_D

0.09167

0.945

143_L

147_G

0.09157

0.944

141_L

148_R

0.09155

0.944

46_F

166_S

0.09082

0.936

80_L

158_A

0.09031

0.931

67_L

88_F

0.09014

0.929

112_A

155_L

0.09012

0.929

127_A

172_Q

0.09012

0.929

176_I

188_A

0.0899

0.926

37_Y

167_T

0.08973

0.925

125_V

172_Q

0.08966

0.924

131_L

172_Q

0.08949

0.922

161_V

179_I

0.08927

0.920

18_S

22_W

0.08916

0.919

86_P

128_F

0.08902

0.917

28_W

158_A

0.08894

0.917

65_R

182_A

0.08868

0.914

27_P

161_V

0.08854

0.912

66_A

188_A

0.08809

0.908

22_W

141_L

0.0875

0.902

136_A

160_N

0.08743

0.901

69_L

81_F

0.08733

0.900

20_Q

172_Q

0.08723

0.899

22_W

157_L

0.0868

0.895

72_L

182_A

0.08656

0.892

38_A

48_V

0.08653

0.892

37_Y

141_L

0.08639

0.890

48_V

105_G

0.08634

0.890

18_S

32_I

0.08633

0.890

179_I

188_A

0.08571

0.883

19_L

22_W

0.08563

0.882

46_F

136_A

0.08561

0.882

37_Y

131_L

0.08513

0.877

157_L

160_N

0.08502

0.876

85_P

128_F

0.08496

0.876

76_V

79_I

0.08474

0.873

74_G

167_T

0.08436

0.869

149_P

183_A

0.08434

0.869

23_L

27_P

0.08414

0.867

52_A

160_N

0.08411

0.867

19_L

36_A

0.0841

0.867

20_Q

23_L

0.08401

0.866

25_S

32_I

0.08398

0.865

28_W

46_F

0.08397

0.865

23_L

32_I

0.08392

0.865

127_A

167_T

0.08386

0.864

50_L

135_W

0.08379

0.864

37_Y

129_P

0.08374

0.863

59_R

62_R

0.08373

0.863

107_F

111_H

0.08359

0.861

158_A

161_V

0.08323

0.858

68_L

80_L

0.08322

0.858

83_A

127_A

0.08303

0.856

72_L

143_L

0.08287

0.854

50_L

151_W

0.08274

0.853

24_A

187_L

0.08271

0.852

74_G

127_A

0.08265

0.852

132_H

173_H

0.08265

0.852

137_V

186_L

0.08251

0.850

78_Y

83_A

0.08193

0.844

32_I

50_L

0.08189

0.844

57_P

183_A

0.08185

0.844

84_A

90_P

0.08156

0.841

66_A

138_L

0.0815

0.840

135_W

163_I

0.08138

0.839

86_P

169_Y

0.08131

0.838

37_Y

82_P

0.08126

0.837

20_Q

85_P

0.08125

0.837

184_L

188_A

0.08122

0.837

26_H

76_V

0.08113

0.836

76_V

104_G

0.08113

0.836

89_L

123_N

0.08103

0.835

139_C

143_L

0.08102

0.835

31_W

34_A

0.08092

0.834

48_V

151_W

0.0809

0.834

43_Q

183_A

0.08085

0.833

127_A

133_V

0.08081

0.833

73_I

183_A

0.08076

0.832

127_A

131_L

0.08064

0.831

101_P

143_L

0.08055

0.830

112_A

179_I

0.08055

0.830

45_A

182_A

0.08029

0.827

45_A

57_P

0.08027

0.827

158_A

187_L

0.08024

0.827

154_A

161_V

0.08018

0.826

127_A

134_A

0.07998

0.824

128_F

131_L

0.07991

0.824

163_I

185_A

0.07974

0.822

49_L

143_L

0.07973

0.822

78_Y

131_L

0.07946

0.819

126_A

170_T

0.0794

0.818

41_F

79_I

0.07938

0.818

43_Q

139_C

0.07937

0.818

53_L

69_L

0.07931

0.817

176_I

180_A

0.0793

0.817

70_A

142_A

0.07902

0.814

63_F

139_C

0.07901

0.814

125_V

185_A

0.07901

0.814

28_W

161_V

0.079

0.814

69_L

72_L

0.07878

0.812

78_Y

178_V

0.07865

0.811

36_A

73_I

0.07863

0.810

64_F

87_R

0.07842

0.808

32_I

45_A

0.07841

0.808

55_R

80_L

0.07833

0.807

164_L

168_V

0.07821

0.806

133_V

137_V

0.07807

0.805

43_Q

47_V

0.07795

0.803

138_L

174_Y

0.07795

0.803

102_V

107_F

0.07779

0.802

53_L

57_P

0.07756

0.799

60_F

136_A

0.07753

0.799

74_G

170_T

0.07752

0.799

85_P

170_T

0.0774

0.798

54_R

187_L

0.07725

0.796

43_Q

171_G

0.07719

0.796

73_I

79_I

0.07672

0.791

76_V

149_P

0.07662

0.790

54_R

77_I

0.07649

0.788

56_R

59_R

0.07633

0.787

169_Y

172_Q

0.07599

0.783

55_R

165_F

0.07591

0.782

161_V

183_A

0.07586

0.782

47_V

188_A

0.07584

0.782

54_R

57_P

0.07579

0.781

147_G

159_F

0.07572

0.780

179_I

186_L

0.07559

0.779

Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.

HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits: Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)