Human Glutamate Receptor, Metabotropic 3 (GRM3) interaction partners

Significant association was found between rs12704290 in GRM3 gene and schizophrenia(SCZ). A three-SNP LD spanning GRM3Delta4 splice site was significantly associated with SCZ. Interaction between the LD block and cognitive function was found in SCZ patients.

Results show that GRM3 rs274622 C carriers with schizophrenia were associated with significantly smaller prefrontal activation than patients with TT genotype

Grm3 expression was decreased in B cells from patients with autoimmune diseases such as activated systemic lupus erythematosus and multiple sclerosis.

Pharmacogenetic relationships were identified in patients with schizophrenia between GRM3 variants and symptom response to antipsychotics.

Findings suggest that mGluR2 (show GRM2 ELISA Kits)/3 and mGluR5s are unaltered in the anterior cingulate cortex in psychotic and nonpsychotic depression, bipolar disorder and schizophrenia

Results demonstrate no changes in expression and density of both 5-HT2AR and mGlu2 (show GRM2 ELISA Kits)/3R in the postmortem prefrontal cortex of subjects with major depressive disorder under basal conditions; antidepressant treatment induces a decrease in 5-HT2AR density

The data of this study suggest an association of the GRM3 rs6465084 polymorphism with changes in pursuit maintenance after antipsychotic treatment.

This study provided that the evidence for an association between GRM3 genotype and schizophrenia and suggest a role for glutamate (show GRIN1 ELISA Kits) neurotransmission in the establishment and maintenance of myelinated fibers.

The results of these studies implicate mGlu3 as a major regulator of PFC (show CFP ELISA Kits) function and cognition.

This study demonistrated that mGluR3 knockout mice show a working memory defect.

report we describe a novel neuroprotective function of mGlu3 receptors related to their ability to promote the non-amyloidogenic pathway of APP (show APP ELISA Kits) cleavage in astrocytes, thus enhancing sAPPalpha production

The findings support the possibility that interactions between mGlu2 (show GRM2 ELISA Kits)/3 and dopamine may be relevant to the pathophysiology and therapy of schizophrenia and other disorders

mGluR3 knockouts did not differ from controls in reinstatement of drug-seeking behavior, suggesting that mGluR2 (show GRM2 ELISA Kits) receptors are critical in mediating addictive-like behavior.

Metabotropic Glutamate Receptor 3 (GRM3) Antigen Profile

Antigen Summary

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.