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Methods of treating allergies using TGF-β1 and allergens

Methods of treating allergies using TGF-β1 and allergens

外国特許コード

F100002265

整理番号

P05-028US

掲載日

2010年9月30日

出願国

アメリカ合衆国

出願番号

36337106

公報番号

20070048328

公報番号

7744895

出願日

平成18年2月28日(2006.2.28)

公報発行日

平成19年3月1日(2007.3.1)

公報発行日

平成22年6月29日(2010.6.29)

優先権データ

特願2005-252912
(2005.8.31)
JP

発明の名称
（英語）

Methods of treating allergies using TGF-β1 and allergens

発明の概要（英語）

(US7744895)The invention provides an allergy prevention method or treatment method, diets and oral drugs enabling prevention/treatment of allergic symptoms without trouble such as systemic adverse reaction, immune deficiency and the like caused by transdermal/intravenous administration of TGF-&bgr;. The allergy prevention method or treatment method is to orally administer 100 μg/kg or more of transforming growth factor-beta (TGF-&bgr;) relative to a weight of an administration target body and thereby selectively suppress Th2 immune response, while with respect to the diets and oral drugs, the content is set to contain an effective amount of transforming growth factor-beta (TGF-&bgr;) therein.

特許請求の範囲（英語）

[claim1]1. A method of treating a food allergy, wherein said method comprises: providing isolated transforming growth factor beta 1 (TGF-beta 1) in an amount of 100 mu g/kg to 250 mu g/kg, relative to a weight of an administration target body, providing a causal substance of allergy, combining the isolated TGF-beta 1 and causal substance of allergy, administering orally and simultaneously the combination to the administration target body in need thereof, wherein said causal substance of allergy is at least one food allergen and, wherein the method of treating allergy results in a non-transient immunological response; thereby treating the food allergy.[claim2]2. The allergy treatment method according to claim 1, wherein the TGF-beta 1 is human TGF-beta 1.[claim3]3. The method according to claim 1, wherein said administration target body is a human.[claim4]4. The method according to claim 1, wherein said administration target body is a mouse.[claim5]5. The method according to claim 1, wherein the combination is administered every other day for a total of six dosages.[claim6]6. The method of treating allergy according to claim 1, wherein 5 mu g of TGF-beta 1 are administered simultaneously with oral intake of the causal substance of allergy, to a mouse.[claim7]7. The method according to claim 1, wherein the causal substance of allergy is administered to the target body in an amount of from 3 to 5 mg per gram of target body weight.[claim8]8. The method of claim 1, wherein the food allergen is selected from the group consisting of milk, egg, rice, buckwheat, seafood and mixtures thereof.[claim9]9. The method of claim 1, wherein the causal substance of allergy is ovalbumin of an egg.[claim10]10. The method of claim 1, wherein the food allergen is in a milk product.[claim11]11. The method of claim 1, wherein the food allergen is in a rice cake.[claim12]12. The method of claim 1, wherein the food allergen is in a yogurt.[claim13]13. The method of claim 1, wherein the food allergen is in a noodle.[claim14]14. The method of claim 1, wherein the food allergen is in a flour.[claim15]15. The method of claim 1, wherein the food allergen is in a pancake mix.[claim16]16. The method of claim 1, wherein the food allergen is in a chocolate.[claim17]17. The method of claim 1, wherein the food allergen is in a biscuit.[claim18]18. The method of claim 1, wherein the food allergen is in a pudding.