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Therapeutic Development for Maintenance of Immunity in Acute Radiation Syndrome

Posted by: Postdoc positions by NIH

Posted date: 2017-Aug-11

Location: USA

Position Description:Exposure to  radiation devastate the peripheral immune system, killing both naïve and memory T cells. Although, naïve T cells recover, memory T cells mediating vaccine immunity are permanently lost rendering a victim highly susceptible to infection. There is no treatment to globally preserve vaccine immunity following ionizing radiation exposure. We have found that memory T cell responses can be preserved by revaccination within 3-4 days post-irradiation (Vaccine 2015;33:3865). Revaccination is impractical in a radiological mass casualty situation. Our goal is to develop a practical therapeutic that mimics the survival, cell cycle, and other signaling pathways stimulated by T cell activation. This work is funded by a NIAID MCMi grant, and will require expertise in immunology and animal models of infectious disease. Qualifications:Knowledge of pharmacology, toxicology, and cell signaling are desirable, but not required.