CoQ10 Study Yields Important Results and Considerations

Introduction

One of the most important nutrients for heart health is coenzyme Q10 (CoQ10). Its role in the heart is similar to the role of a spark plug in a car engine. Just as the car cannot function without that initial spark, the heart cannot function without CoQ10. Although the body can make CoQ10, considerable research shows significant benefits with supplementation in various health issues and in people taking cholesterol-lowering drugs (e.g., statins like Lipitor and Crestor).

Results from a very detailed study conducted at research centers throughout Europe and Asia not only show beneficial effects in patients with chronic heart failure (CHF), but also provides some insight on the importance of effective dosage of CoQ10.

Background Data:

CoQ10 is an essential component of the mitochondria, where it plays a major role in energy production. Deficiency of CoQ10 can be a result of impaired production due to nutritional deficiencies, a genetic or acquired defect in CoQ10 synthesis (e.g., statin drugs block CoQ10 formation), or increased tissue needs. Cardiovascular diseases, including angina, hypertension, mitral valve prolapse, and CHF, are examples of diseases that require increased tissue levels of CoQ10. In addition, many elderly people may have increased CoQ10 requirements. In a 5-year double-blind placebo-controlled study of healthy elderly people, daily supplementation with a combination of CoQ10 (200 mg) and selenium (200 mcg) reduced cardiovascular mortality by 46%.

In the treatment of chronic heart failure, studies have most often used CoQ10 as a support aid (adjunct) to conventional drug therapy. The improvements noted with CoQ10 were actually found to be more positive than those obtained from conventional drug therapy used alone in these studies. However, the studies have not yet answered several important questions including what is the optimal form and dosage of CoQ10 and what effect does CoQ10 have on reducing mortality in patients with CHF.

New Data:

CoQ10 was evaluated as an adjunctive treatment of CHF in a randomized, double-blind, multicenter trial known as Q-SYMBIO – the Q standing for CoQ10 the other letters for SYMptoms, BIomarker status, and long-term Outcome (hospitalisations/mortality).

A total of 420 patients with moderate to severe CHF were randomly assigned in a 2-year trial to either CoQ10 100 mg 3 times daily or placebo, in addition to standard therapy. The primary short-term endpoints at 16 weeks were changes in New York Heart Association (NYHA) functional classification, 6-min walk test, and levels of a biomarker linked to heart function (N-terminal pro–B type natriuretic peptide). The primary long-term endpoint at 2 years was the number of major cardiovascular events (e.g., a heart attack or stroke).

The results showed that in the CoQ10 group there was a significant improvement in CHF as noted by better NYHA class after 2 years. Most importantly, only 15% of the patients in the CoQ10 group had a major cardiovascular event compared to 26% in the placebo group. Death due to a cardiovascular event occurred in 9% in the CoQ10 group vs. 16% in the placebo group; overall mortality was 10% in the CoQ10 group vs. 18% in the placebo group. There were no side effects with CoQ10 or placebo supplementation.

Q-SYMBIO is the first clinical trial with adequate size, dosage of CoQ10, and duration of follow-up to evaluate the efficacy of CoQ10 on morbidity and mortality in CHF. The major endpoint showed that CoQ10 produced a 43% reduction in the risk of dying from a heart attack or stroke.

Commentary:

Improving energy production within the heart muscle (myocardium) is an important goal in any heart condition. Whether the issue is angina, arrhythmia, or heart failure, these sorts of heart conditions are always characterized by impaired energy production within the heart muscle (the myocardium). This impaired energy production is often the result of nutrient or coenzyme deficiency. In addition to CoQ10, nutrients like magnesium, thiamin, carnitine, and pantethine are also important considerations..

An important issue for many patients with CHF, especially more serious forms, is that they often fail to achieve adequate serum CoQ10 levels (i.e., more than 2.5 mcg/ml) on supplemental ubiquinone (the common form of CoQ10), even at dosages of up to 900 mg/day. These patients may respond better with highly absorbed forms of CoQ10, such as ubiquinol or emulsified ubiquinone.

In the Q-SYMBIO study, the average serum CoQ10 level in the supplement group was 1.14 µg/ml at baseline; 3.0 at week 16; and 2.0 at week 106. What this signifies to me is that some of the subjects may not have achieved sufficient blood levels of CoQ10. Clearly, most subjects had good initial response, but over time something happened and CoQ10 levels declined. Was this do to impaired absorption, poor compliance (did some patients stop taking the supplement for some reason), reduced manufacture in the body due to drug interactions (e.g., statin use), or was there was an increased need for higher dosage levels over time?

My recommendation is that in a serious health condition like CHF, that it makes sense to use the ubiquinol form at 100 mg three times daily unless blood levels of CoQ10 are being monitored while on regular CoQ10 (ubiquinone)

Welcome

On the Dr Oz show

On the show I discussed the failure of conventional medicine to address the underlying issues in many health conditions offering little more than drugs as biochemical “band aids.”

December is Seasonal Affective Disorder Awareness Month

In seasonal affective disorder (SAD) is associated with winter depression Typically, these individuals not only feel depressed they also feel tried, slow down, and generally oversleep, overeat, and crave carbohydrates in the winter. In the summer, these same patients feel very good and maybe even are elated, active, and energetic.

Although many variables may be responsible for SAD, insufficient light exposure is the most logical explanation. Many mammals exhibit seasonal variations in activity level, sleep patterns, and appetite and are extremely sensitive to changes in day length. The antidepressant effects of full-spectrum light therapy have been demonstrated in well-monitored, controlled studies in SAD. The antidepressant effect of light therapy is probably due to the restoration of proper melatonin synthesis and secretion by the pineal gland, leading to reestablishment of the proper circadian rhythm. Full-spectrum white light (10,000 lux) is prescribed for at least 30 minutes every day in the morning. Or, better yet, use full-spectrum lighting throughout the indoor environment.

The key hormonal change caused by exposure to full spectrum lighting may be a reduced secretion of melatonin from the pineal gland and an increased secretion of cortisol by the adrenal glands. Melatonin supplementation is thought to improve SAD because it increases brain melatonin levels, but it may also suppress cortisol secretion.Take 3-5 mg 45 minutes before retiring.

Vitamin D is also an important consideration. Many experts recommend a dosage of 2,000 to 5,000 IU of vitamin D3 daily, especially during the winter months.

Mind Your Ps and Qs

PQQ may be the perfect answer to preventing or reversing age-related mental decline.

kiwiPQQ (short for pyrroloquinoline quinone) is a vitamin-like compound found in plant foods that shows a wide range of benefits for brain function and energy production. Learn more about PQQ with the following Q&A.
What Exactly Does PQQ Do?

PQQ is an extremely potent antioxidant that is able to carry out the role of an antioxidant in the body more than 20,000 times—which is a rare thing. For example, other antioxidants, such as vitamin C, are only able to accomplish this “cycling” process about four times.
Are There Any Food Sources of PQQ?

PQQ has been found in all plant foods analyzed to date. Particularly PPQ-rich foods include parsley, green peppers, kiwi, papaya, and tofu. These foods contain 2–3 mcg of PQQ per 100 grams. Green tea provides about the same amount per 4-oz. serving. While these amounts appear to be sufficient in helping our cells carry out their basic functions, research indicates that boosting PQQ through supplementation can produce some amazing effects.