Zoology and wildlife conservation

Oncogenic activity of Cdc6 through repression of the INK4/ARF locus

Article Abstract:

A study was carried out to identify a putative DNA replication origin at INK4/ARF locus that assembles a multiprotein complex containing Cdc6, Orc2 and MCMs that coincides with a conserved noncoding DNA element, regulatory domain RD(super INK4/ARF). The findings conclude that aberrant expression of Cdc6 is oncogenic by directly repressing the INK4/ARF locus through the RD(super INK4/ARF) element.

Policing of oncogene activity by p53

Article Abstract:

A demonstration that p53-dependent protection against cancer is lost in mice that are genetically manipulated so that their p53 is activated in response to DNA damage but not to oncogenic signalling is presented. Results reveal that oncogenic signalling is the critical event that elicits p53-dependent protection and that the NDA-damage stimulus is less important.

Delayed ageing through damage protection by the Arf/p53 pathway

Article Abstract:

The tumor-suppressor pathway formed by Cdkn2a locus (Arf) and p53 causes delayed ageing by detecting and eliminating any kind of cellular damage. The pathway due to its anti-ageing activity hence can be easily used for the co-evolution of cancer resistance and longevity.