The flu season has hit Pawnee hard, leaving nurse Ann Perkins caring for many sick citizens at Saint Joseph Hospital. Among them is April Ludgate, who constantly mistreats Ann in retaliation for kissing Andy Dwyer. April asks Ron Swanson not to tell Andy she is in the hospital, and Ron is anxious not to get involved in their personal affairs. Leslie Knope also has the flu, but will not admit it because she wants to give an important presentation to the Pawnee Chamber of Commerce about the planned Harvest Festival, which she hopes will restore the dwindling budget of the parks department. Ben Wyatt finally takes a reluctant Leslie to the hospital, where she is admitted with a dangerously high fever and dehydration. Ben decides to do the presentation on Leslie's behalf, much to the chagrin of Leslie, who does not trust anyone but herself to do it. Tom Haverford, who was assigned to help Ben, immediately abandons him to hang out with a group of older men at the spa.

To Ann's surprise, Chris Traeger has also been admitted to the hospital with the flu. The two have been dating and, although Ann really likes Chris, she fears he is too perfect. However, because the extremely health-conscious Chris has a poor immune system and nearly no body fat, he suffers a complete physical breakdown, which makes Ann feel less intimidated about dating him. Meanwhile, Leslie escapes the hospital and heads back to City Hall to deliver the presentation herself. Tom returns from the spa, revealing his spa friends are the owners of several car dealerships, which have agreed to lend vehicles to the festival. Although delirious with fever and an excess of flu medication, Leslie delivers a flawless presentation, wildly impressing Ben. She is immediately brought back to the hospital, where Ben tells her 110 businesses have agreed to help with the festival, surpassing the minimum 80 needed.

At the department, with April absent from work, Ron asks Andy to fill in as an assistant because the anti-government-oriented Ron believes Andy will be ineffective. The two bond over the course of the day, and Andy begins to tell Ron about his problems with April, for whom he still harbors romantic feelings. Although initially not wishing to get involved, Ron reluctantly tells Andy she is at the hospital and he should visit her. Meanwhile, Ann remains pleasant throughout her nursing shift despite April's constant abuse. The second her shift ends, however, Ann immediately loses her temper and curses at April. Ann apologizes for kissing Andy, but insists it was a mistake and that April should stop taking it out on Andy. Later, Andy visits April, who pretends to be asleep but smiles, revealing she is happy he came.

At the end of the episode, Chris tells Ben they have been called back to Indianapolis for a new assignment, but both agree to seek an extension to stay in Pawnee longer. Although both claim they want to help organize the Harvest Festival, it is hinted they really want to stay because of Leslie and Ann.

Andy's line "Leslie, I typed your symptoms into the thing up here, and it says you could have 'network connectivity problems'" was improvised by Chris Pratt. Creator Michael Schur said he thinks its one of the best jokes in the series, though as a writer, it drives him crazy that such a great line was improvised.

Ron:[to April] Here. I didn't know what to bring you, so I just got some magazines and lipstick. Woman stuff.

Ron: The less I know about other people's affairs, the happier I am. I'm not interested in caring about people. I once worked with a guy for three years and never learned his name. Best friend I ever had. We still never talk sometimes.

Ron: I need to find someone to fill in for April. Now I know I'm not going to find someone who's both aggressively mean and apathetic. April really is the whole package.

Andy: Do I have to tuck my shirt in? Because, honestly, that's kind of a dealbreaker.Ron: Let it fly.

Leslie: Ann's my doctor. And she's the most beautiful nurse in the world.

Andy:[pointing to the computer] Leslie, I typed your symptoms into the thing up here and it says you could have network connectivity problems.

Leslie: If I was sick, could I do this?Ann: What are you doing?Leslie: Cartwheels. Am I not doing them?Ann: No.

Leslie: It's not that I don't trust Ben. It's that I don't have faith in Ben. And also I'm starting to forget who Ben is.

Leslie:[to Ben] OK, so let's, um, talk about your opening remarks. Do you want me to write you a rap? I'll write you a rap. No, you know what? You'll never be able to pull it off. You're too white. How about a show tune or something?

Andy: Let me go to Big Head Joe's for you. They have the most insane burritos.Ron: I don't much go for ethnic food.Andy: No no no. Trust me. They have one that's called the meat tornado. Literally killed a guy last year.Ron: You had me at meat tornado.

Ron: I like Andy. I'm surrounded by a lot of women in this department. And that includes the men.

Chris: I had a dream. That she came into this room. Stole all my flu medicine and told me not to tell you and disappeared through that hole in the wall.Ann: The door?

Chris: I vomited somewhere in this room. I don't remember where, though. Wait. You might want to check that drawer.

Chris: Stop. Pooping!

Leslie: Oh, boy. Hold on. Be careful.

Ben: What?Leslie: The floor and the wall just switched. Walk very carefully.

Leslie: That's a very good question, sir. And I would counter with my own question, which is: Why is half of your face all swirly?

Leslie: Was I wearing a tiara when I came in here? Because if you happen upon it, would you have Lady Pennyface retrieve it and send it post-hence?

Ben: I got you some waffles here courtesy of J.J.'s Diner. And chicken soup courtesy of me.Leslie: I'll take the waffles.