Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))* All genome coordinats were lifted-over on hg19.* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Dioxygenase that catalyzes the conversion of themodified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in active DNAdemethylation. Has a preference for 5-hydroxymethylcytosine in CpGmotifs. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine(5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probablyconstitutes the first step in cytosine demethylation. Methylationat the C5 position of cytosine bases is an epigenetic modificationof the mammalian genome which plays an important role intranscriptional regulation. In addition to its role in DNAdemethylation, also involved in the recruitment of the O-GlcNActransferase OGT to CpG-rich transcription start sites of activegenes, thereby promoting histone H2B GlcNAcylation by OGT.{ECO:0000269|PubMed:19483684, ECO:0000269|PubMed:21057493,ECO:0000269|PubMed:21817016, ECO:0000269|PubMed:23222540,ECO:0000269|PubMed:23353889, ECO:0000269|PubMed:24315485}.

May play a role in EPS8 signaling. Binds glutathione.{ECO:0000269|PubMed:19528316}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at