Generic ( Intermediate Acting Human Insulin Protamine )

Typical use Of Intermediate Acting Human Insulin Protamine :

For The Treatment Of Type 1 Or 2 Diabetes Mellitus.

Mechanism of action of Intermediate Acting Human Insulin Protamine :

The Binding Of Insulin To The Alpha Subunit Of IR Stimulates The Tyrosine Kinase Activity Intrinsic To The Beta Subunit Of The Receptor. The Bound Receptor Autophosphorylates And Phosphorylates Numerous Intracellular Substrates Such As Insulin Receptor Substrates (IRS) Proteins, Cbl, APS, Shc And Gab 1. Activation Of These Proteins Leads To The Activation Of Downstream Signaling Molecules Including PI3 Kinase And Akt. Akt Regulates The Activity Of Glucose Transporter 4 (GLUT4) And Protein Kinase C (PKC), Both Of Which Play Critical Roles In Metabolism And Catabolism.