Im playing with Tekken 5, and thank god after a few hours of configurating it runs flawlessly, but im still not satisfied with the picture sharpness.
Im runing the PAL version with my PAL bios, but the screen was flickering so i need to use some interlacing, and the bob tff seems to be the best, also i use the game with its native resolution in Direct3D9 - Hardware, and then pop it to fullscreen - there is a picture about it in the attachment.

The Vertical lines should disappear, do you still have some of them? maybe the PAL vesion of the game is different. I have NTSC.
And I didn't change GS windows settings I leaved them at default, only the settings in the attachment I posted above.
Can you post a picture of GSDx settings ?
As for ghosting In such stages like Garden, Moonlit Wilderness & Acid Rain thats normal. so try different stages than these.

Go into the game's display options and change the video mode to PAL60/60hz, then change the scan mode to sharp (may need to go into a fight then out to the display settings again for the scan mode option to appear), that should help with sharpness but problem is it only works for the game session you activate it and next time you boot the game you will need to do it again I think