Angiotensin-converting-enzyme (ACE) inhibitor: Drug which decreases the function of this particular enzyme. The angiotensin-converting-enzyme changes a compound called angiotensin I to angiotensin II. Angiotensin II is a potent blood vessel constrictor. ACE inhibitors, then, have the effect of dilating blood vessels, since less Angiotensin II is produced.

A fluid containing a high proportion of hydrogen ions, giving the liquid a sour taste. Measured by pH units, with 1 the most acid, and 14 the least acid. Chemical reactions in the body have to take place at or near neutrality, pH 7.

Immunity produced when an animal’s own immune system reacts to a stimulus e.g., a virus or bacteria, and produces antibodies and cells which will protect it from the disease caused by the bacteria or virus. Compare with 'passive immunity.'

Addison's disease is also known as hypoadrenocorticism. It is a disease that results from a decrease in corticosteroid secretion from the adrenal gland. See article: Addison's Disease (Hypoadrenocorticism) in Dogs.

Communication between the nerves and muscles that uses epinephrine as the 'messenger.' Adrenergic stimulation is what is involved in the 'flight or fight' response, which means the body is alerted to a danger of some sort and prepares to basically run or fight. Adrenergic stimulation results in an increased heart rate, sweating, and increased blood pressure.

A protein in the blood responsible for the maintenance of osmotic (water) pressure in the blood; also binds (attaches) to large molecules in the blood and serves to transport them; produced by the liver; also called 'serum albumin.'

A class of antibiotics which act by interfering with bacterial protein synthesis within the bacteria which results in the death of the bacteria. Antibiotics in this class include gentamicin (Gentocin), kanamycin, neomycin, streptomycin, tobramycin, and amikacin. Many of these antibiotics are not well-absorbed from the animal's digestive system, so are often administered as injections, or used topically.

The faster and greater immune response produced by an animal who has previously encountered that specific antigen. Memory cells are responsible for this more efficient response. Also called 'secondary response.'

Anaphylaxis is a rare, life-threatening, immediate allergic reaction to something ingested or injected. If untreated, it results in shock, respiratory and cardiac failure, and death. See article: Anaphylaxis in Dogs and Cats. May also be referred to as anaphylactic shock or anaphylactoid reaction.

(ACE inhibitor) Drug which decreases the function of this particular enzyme. The angiotensin-converting-enzyme changes a compound called angiotensin I to angiotensin II. Angiotensin II is a potent blood vessel constrictor. ACE inhibitors, then, have the effect of dilating blood vessels, since less Angiotensin II is produced.

Small disease-fighting proteins produced by certain types of cells called 'B cells.' The proteins are made in response to 'foreign' particles such as bacteria or viruses. These antibodies bind with certain proteins (antigens) on foreign particles like bacteria, to help inactivate them. See also Antigen.

A measurement of the amount of antibodies in the blood. The test to measure antibodies is usually performed by making a number of dilutions of the blood and then measuring at what dilution there is sufficient antibody to react in the test. For example, a titer of 1:8 (one to eight) means the blood can be diluted to one part blood and seven parts saline and still produce a positive reaction in the test. The higher the titer (1:16 is higher than 1:8), the more antibody is present.

Stopping the communications between certain nerves and muscles of the body including those of the gastrointestinal tract and heart. These nerves are called 'parasympathetic' nerves and do such things as constrict the pupils of the eye, stimulate contractions of the muscles in the intestine, and slow the heart rate. Anticholinergic drugs would have the effect, then, of dilating the pupil, slowing contractions of the intestines, and increasing the heart rate.

A molecular structure on surfaces of such particles as bacteria and viruses. This structure is recognized by the body as 'foreign' and stimulates the body to produce special proteins called antibodies to inactivate this foreign invader. See also Antibody.

An agent that relieves or decreases spasms in muscle. The muscle could include 'smooth muscle' which is the type of muscle in intestines that causes them to contract and move food through the digestive system.

Withdraw fluid or cells through the use of suction - usually the suction produced by pulling back on the plunger of a syringe attached to a needle which is inserted into the area to be sampled. Also the breathing in of a fluid or foreign substances.

A heart condition in which the atria (chambers of the heart that receive the blood) contract rapidly, irregularly, and independently of the ventricles (the chambers of the heart that pump the blood). This greatly decreases the efficiency of the heart and its ability to move blood.

A heart condition in which the atria (chambers of the heart that receive the blood) contract rapidly, irregularly, and independently of the ventricles (the chambers of the heart that pump the blood). This greatly decreases the efficiency of the heart and its ability to move blood.

A condition in which the immune system attacks the body's own tissues. To properly function, the immune system must identify foreign substances such as bacteria, viruses, parasites, slivers, etc., and it must be able to distinguish normal body tissue from these foreign substances. If it fails to distinguish the difference, it attempts to destroy the tissue it wrongly identifies as foreign. For example, in autoimmune hemolytic anemia, the body destroys its own red blood cells. In rheumatoid arthritis it attacks the cells in the joints.

Heart medications which block certain receptors in the heart called beta receptors. The beta receptors receive signals which generally increase the heart rate. If the heart rate is abnormally fast and uneven, beta blockers will help stabilize the rate and rhythm of contractions.

A condition in which the cells of the bone marrow which produce red blood cells, white blood cells, and platelets are inhibited. This may result from the use of certain drugs, such as anti-cancer agents.

Compounds made up of chains of sugar units. Simple carbohydrates include table sugar (sucrose), milk sugar (lactose), and fruit sugar (fructose). Complex carbohydrates are very long chains held together by bonds that may not be digestible in the stomach and intestine of a carnivore. Starch is a digestible complex carbohydrate. Seed hulls such as oat bran are digestible by ruminants and horses, but not carnivores.

An animal which harbors an infectious organism, such as a virus, bacteria, or parasite. The animal does not appear ill, but can still transmit the organism to other animals by direct contact or releasing the organisms (bacteria, protozoa, viruses) into the environment in the stool, urine, respiratory secretions, or vaginal discharges.

The removal of the sex organs making the animal incapable of reproduction; the correct use of the word can be used to describe both male and female animals, but it is commonly used to describe only males.

Disease caused by large numbers of worms in the right side of the heart and vena cava, which results in blood circulation problems in the liver leading to the breakdown of red blood cells, anemia, weakness, and collapse.

The immunity that is the result of either special lymphocytes directly killing the foreign invader, or lymphocytes (T cells) releasing special chemicals which activate macrophages to kill the invader. Compare with 'humoral immunity.'

A chronic condition of the eye in which blood vessels grow across the cornea (the clear surface of the eye). The cornea looks hazy and sometimes reddened; it may eventually take on a dark pigment. This condition is also called pannus.

Protein components in the blood which help it to clot. Clotting is a complex mechanism. In addition to platelets, clot formation is the result of a long chain of chemical reactions carried out by individual molecules called 'clotting factors.' Each factor is numbered such that factor I leads to a reaction with factor II forming a new substance. This then reacts with factor III and so on to factor XII.

A common medical condition in older dogs that results from abnormal brain function, causing certain behavior changes such as disorientation, housebreaking problems, and changes in sleeping patterns and interactions with others.

A count of the total number of cells in a given amount of blood, including the red and white blood cells; often referred to as a 'CBC,' it is one of the most common tests done to check for abnormalities of the blood.

Hormones produced by the adrenal gland which are important to almost every function of cells and organs. They are divided into two groups: glucocorticoids and mineralocorticoids. Glucocorticoids regulate protein, carbohydrate, and fat metabolism. Mineralocorticoids regulate electrolyte balances.

Cushing's disease is also known as hyperadrenocorticism. It is a disease that results from an increase in corticosteroid secretion from the adrenal gland. See article: Cushing's Disease (Hyperadrenocorticism) in Dogs.

Expressed as a percent, is a measure of the content of food that is retained in the body after food is eaten. The difference between the weight of food eaten and the weight of stool produced, divided by the weight of the food.

Canine distemper is a viral disease that causes a severe and often fatal systemic illness in dogs and their close relatives. Distemper is also fatal in animals such as raccoons, and mustelids including skunks, mink, and ferrets.

An animal that has been housed and fed by man for generations and has little fear of man as a result. Some domestic animals learn to depend on human provision so completely that they have little ability to survive if returned to a natural habitat.

Keratoconjunctivitis sicca (KCS) is the technical term for a condition also known as 'dry eye.' It occurs because of inadequate tear production. Symptoms include a thick, yellowish discharge from the eye.

Length of time an animal is protected from a disease. Vaccines for some diseases provide long durations of immunity (years), while vaccines for some other diseases only provide immunity that lasts for 6 months.

The membrane that divides the outer ear from the inner ear, where the mechanism of hearing takes place. The membrane prevents infection from reaching the inner ear, as well as vibrating to amplify sounds.

Chemically, an element when dissolved in water, will cause the solution to transmit electricity. In medicine, certain elements in the blood which are critically important to life, including sodium, potassium, chloride, calcium, and phosphorous.

First generation: A description of medications developed from an earlier form of the medication. First generation medications were developed from the original form of the drug; second generation medications are adaptations of first generation drugs; third generation drugs are adaptations of second generation, etc.

An x-ray procedure in which x-rays are transmitted through the body onto a fluorescent screen; beneficial in that movement of joints or organ systems can be observed (e.g., the movement of material through the esophagus, stomach, and intestines).

Feline lower urinary tract disease; a condition in cats characterized by blood in the urine, urination outside of the litter box, and straining to urinate. The name for this condition was previously called feline urological syndrome (FUS).

Feline urological syndrome; a condition in cats characterized by blood in the urine, urination outside of the litter box, and straining to urinate. The name for this condition is now called feline lower urinary tract disease (FLUTD).

Hormones produced by the adrenal gland which regulate protein, carbohydrate and fat metabolism, and are important to almost every function of cells and organs. They also stabilize cell membranes which is an important part of their function in treating allergic reactions. Also called glucocorticosteroids.

Hormones produced by the adrenal gland which regulate protein, carbohydrate and fat metabolism, and are important to almost every function of cells and organs. They also stabilize cell membranes which is an important part of their function in treating allergic reactions. Also called glucocorticoids.

A classification of bacteria based upon their lack of retention of a certain stain in the laboratory. The staining quality is based on the structure of the cell wall surrounding the bacteria. This structure of the cell wall influences which antibiotics will kill the bacteria. This laboratory staining method was developed by Hans Gram in 1884.

A classification of bacteria based upon their uptake of a certain stain in the laboratory. The staining quality is based on the structure of the cell wall surrounding the bacteria. This structure of the cell wall influences which antibiotics will kill the bacteria. This laboratory staining method was developed by Hans Gram in 1884.

A compound which binds (attaches) to the area on a cell at which histamine also binds. By binding at the same site, the antagonist blocks histamine from binding and prevents histamine from producing its effects, which include the production of stomach acid.

A species of parasitic worm (Dirofilaria immitis) that lives and reproduces in the chambers of the heart of an animal. Microscopic, immature worms (microfilariae) circulate in the blood and are taken in by mosquitoes that bite the animal. Microfilariae mature in the mouthparts of the mosquito and infect another susceptible animal bitten by the same mosquito.

A condition in which the red blood cells are destroyed and this results in anemia. The specific type of anemia is called 'Heinz body anemia' because the red cells develop an abnormality called a 'Heinz body' which can be seen under the microscope. This anemia can occur as a reaction to certain medications and also in cats who eat onions.

PCV (Packed Cell Volume), hematocrit: A laboratory test to monitor relative number of red blood cells present in the blood. A blood sample is placed in a tiny glass tube and spun in a centrifuge. The cells are heavier than the plasma and are compacted at one end of the tube. After the tube is spun, it is examined and the packed cell volume is determined as the percentage of the red cellular portion relative to the total amount of blood in the tube (i.e. remainder being the plasma). The normal for dogs is 40-59 and cats is 29-50.

A modified live vaccine that contains a higher number of virus particles than the 'average' vaccine. High titer vaccines can generally elicit an immune system response in young animals who have a maternal antibody level that would prevent them from responding to an 'average' vaccine.

A compound which binds (attaches) to the area on a cell at which histamine also binds. By binding at the same site, the antagonist blocks histamine from binding and prevents histamine from producing its effects, which include the production of stomach acid.

Abnormal increase in the amount of tissue, e.g., a hyperplastic ear would have increased numbers of cells in the ear canal, sometimes to the point of closing off the ear canal. In prostatic hyperplasia, the prostate enlarges due to an increased number of normal, not cancerous, cells.

Insulin dependent diabetes mellitus (IDDM): A form of diabetes in which so little insulin is produced that supplemental insulin must be given for the animal to live. Also called Type I diabetes mellitus.

Immune-mediated reaction or disease: A condition or disease caused by abnormal activity of the immune system in which the body's immune system either over-reacts (e.g., immune-mediated contact dermatitis) or starts attacking the body itself (e.g., autoimmune hemolytic anemia). See also autoimmune.

A condition in which the animal's immune system has been primed and is able to protect the body from a disease-causing agent such as a certain virus or bacteria. An animal could have immunity to one agent, such as parvovirus, but not have immunity to another agent, such as rabies.

The process of rendering an animal protected (immune) against a certain disease. Vaccination is a way to produce immunization. However, just because an animal has been vaccinated (received a vaccine) does not necessarily mean the animal is immune. If the body did not correctly react to the vaccine or if the vaccine was defective, immunity would not occur. No vaccine produces immunity in 100% of the population to which it was given. 'Vaccination' is not the same as 'immunization.'

A condition in which tissue reacts to injury and undergoes changes during the healing process. As an example, a toe with a sliver of wood in it would be inflamed and show the signs of inflammation which include redness, increased temperature, pain, swelling, and a loss of or disordered function. The toe is swollen, red, hot, painful, and the animal is reluctant to walk on that toe.

In the life cycle of some parasites, the immature form of the parasite must pass through a different type of host (animal, insect, snail, etc.), called the intermediate host, before it can re-enter and infect the type of animal it came from. An example would be heartworms. The adult worm lives in the dog or cat. The immature form, laid by the adult heartworm, is taken up by the mosquito. The immature form develops within the mosquito, and is then reintroduced into another dog or cat where it develops into the mature adult and the cycle repeats itself. The intermediate host for heartworms, then, is the mosquito.

The part of the digestive system extending from the stomach to the rectum; includes both the small and large intestines and functions in the absorption of water and nutrients; also called bowel or gut.

The colored portion of the eye is called the iris. As with humans, dogs' iris colors vary. In the center of the iris is the black opening called the pupil. This opening can be made larger or smaller by muscles called ciliary bodies, that attach to the colored iris, causing it to expand or contract.

The condition in which there is a buildup of waste products in the body called bilirubin. Bilirubin is yellow in color, therefore, an animal with jaundice will have yellow gums, skin (often seen on the inside flap of the ear), and a yellowish cast to the 'whites' of the eyes. It can occur if a large number of red blood cells are destroyed, the liver is not functioning normally, or the bile ducts are blocked.

Keratoconjunctivitis sicca (KCS) is the technical term for a condition also known as 'dry eye'. It occurs because of inadequate tear production. Symptoms include a thick, yellowish discharge from the eye.

The larynx is a muscular tube in the neck that allows air to pass from the throat to the trachea (windpipe). The larynx contains the vocal cords, which allow people and animals to make sounds. The larynx has cartilage that opens to allow air into the trachea.

The largest organ in the abdomen, responsible for producing enzymes required for digestion of food, and bile that helps to digest fat. The liver also detoxifies the blood and may be damaged in the process.

A low passage vaccine contains virus particles which have been attenuated, or weakened, less than those in the 'average' vaccine. Low passage vaccines can generally elicit an immune system response in young animals who have a maternal antibody level that would prevent them from responding to an 'average' vaccine.

Part of the immune system of an animal. Small masses of tissue that contain white blood cells called lymphocytes. Blood from the nearby area is filtered through the lymph node allowing foreign or infectious material to be recognized and destroyed if possible.

A nodular growth, usually on the skin, which involves cells (mast cells) which contain large amounts of histamine and normally play a role in allergic reactions. All mast cell tumors in dogs should be considered potentially malignant.

(Immunologic) Memory: When an animal mounts an immune response against a foreign substance, some cells are created to 'remember' the antigens on that substance. If the animal is again exposed to the substance, these cells will help the body respond much faster and to a higher degree.

(MAOI): Substances that inactivate the enzyme monoamine oxidase which regulates certain transmitter chemicals between nerves. These compounds include certain types of antidepressants and also insecticides containing amitraz (such as Mitaban and Preventic collars).

Specialized membrane which covers various passages and cavities exposed to the air such as the mouth, nose, inner portion of the eyelids, vagina. Examination of the mucous membranes can provide important information: if they are dry, the animal is likely dehydrated; pale, and the animal may be anemic or in shock; yellow, and the animal is said to jaundiced due to accumulation of waste products which should be eliminated by the liver. Mucous membranes.

Specialized membrane which covers various passages and cavities exposed to the air such as the mouth, nose, inner portion of the eyelids, vagina. Examination of the mucous membranes can provide important information: if they are dry, the animal is likely dehydrated; pale, and the animal may be anemic or in shock; yellow, and the animal is said to be jaundiced due to accumulation of waste products which should be eliminated by the liver.

A vaccine that combines two or more components to stimulate the body to produce protection against all the components. Most 'distemper' vaccines for puppies are of the multivalent type, and commonly include distemper, parvovirus, adenovirus cough, hepatitis, and parainfluenza. Compare with 'monovalent' vaccine.

Non-insulin dependent diabetes mellitus (NIDDM): A type of diabetes mellitus in which although the blood glucose levels are higher than normal, they are not immediately life-threatening, and the animal can survive without supplemental insulin. Also called Type II diabetes.

A very broad term describing certain components in food (plant or animal) or nutritional supplements, which contain substances normally present in the body that aid in the proper functioning of body systems.

A behavioral condition in which a pet repeatedly performs an action out of context. It is thought that the behavior is an expression of stress, frustration and/or conflict. Certain breeds are more prone to these behaviors. The behaviors include tail-chasing, some cases of excessive barking, continual licking, and biting the air as if snapping at an invisible fly.

Term used to describe the use of a medication for a condition for which it was not FDA approved. A large number of medications used in veterinary medicine are used 'off label.' If veterinarians only used FDA approved medications, options for treatments of certain conditions would be severely limited or nonexistent. The safety and efficacy of off-label uses of medications is often determined in university research settings, but the manufacturer of the drug does submit the results or go through the elaborate FDA approval process.

(PCV), hematocrit: A laboratory test to monitor the relative number of red blood cells present in the blood. A blood sample is placed in a tiny glass tube and spun in a centrifuge. The cells are heavier than the plasma and are compacted at one end of the tube. After the tube is spun, it is examined and the packed cell volume is determined as the percentage of the red cellular portion relative to the total amount of blood in the tube (i.e., remainder being the plasma). The normal for dogs is 40-59 and cats is 29-50.

A chronic condition of the eye in which blood vessels grow across the cornea (the clear surface of the eye). The cornea looks hazy and sometimes reddened; it may eventually take on a dark pigment. This condition is also called chronic superficial keratitis.

The portion of the nervous system which stimulates the pancreas to produce digestive enzymes and stimulates many of the smooth muscles in the body including those of the stomach and intestine. It also tends to slow the heart rate.

Packed cell volume. PCV, hematocrit: A laboratory test to monitor the relative number of red blood cells present in the blood. A blood sample is placed in a tiny glass tube and spun in a centrifuge. The cells are heavier than the plasma and are compacted at one end of the tube. After the tube is spun, it is examined and the packed cell volume is determined as the percentage of the red cellular portion relative to the total amount of blood in the tube (i.e., remainder being the plasma). The normal for dogs is 40-59 and cats is 29-50.

A condition in which the skin reacts abnormally to light, especially ultraviolet light or sunlight. It is usually caused by the interaction of light with certain chemicals in the skin such as antibiotics, other medications, hormones, or toxins.

A substance which is given that has no therapeutic value; often called a 'dummy pill' or 'sugar pill.' Often given to half of the patients in a trial of a new drug, to better assess the effectiveness of the new drug.

Cellular components found in the blood which help clots to form. In the body, microscopically small vessels often break in the normal course of events. Platelets and a protein called fibrinogen 'plug' the break in the vessel and prevent blood from leaking out.

A fatal virus disease of warm blooded animals including man, that affects the brain and is spread in the saliva of infected animals. Rabid animals have a temperament change. Wild creatures become bold enough to attack human beings, and docile domestic animals may turn on their owners.

There are certain antigens on viruses and bacteria which are better at stimulating an antibody response by the animal than others. The genes for these antigens can be isolated, and made to produce large quantities of the antigens they code for. A recombinant vaccine contains these antigens, not the whole organism. Compare with 'modified live vaccine' and 'killed vaccine.'

A term used to describe bacteria which have mutated or changed so they are not affected by an antibiotic that previously killed them or slowed their growth. As more bacteria become resistant to various antibiotics, there are fewer antibiotics which will have an effect on them, thus newer and stronger antibiotics will need to be developed. Inappropriate use of antibiotics (using them too often, for too short a duration or in insufficient dose) may promote the development of resistance.

In pregnancy, a condition in which the fetus dies, and instead of being aborted, the fetal tissue dissolves within the uterus and is absorbed by the mother. The mother will show no outward signs of a fetal resorption.

The rear interior surface of the eyeball is called the retina. The retina contains nerve cells referred to as rods and cones. The rods are sensitive to light and the cones to color. The retina receives the light and color and converts them into nerve impulses which go to the brain.

A condition, caused by a lesion in the spinal cord, in which the front legs are held rigid and straight, and the rear legs are weak or paralyzed. Sometimes, the neck may be hyperextended, with the head held up and over the back.

Inflammation of a sebaceous (oil-producing) gland. In dogs, sebaceous glands are found on the top of the tail near its base, and at the junction of mucous membranes with skin. In cats, these glands are found on the chin, lip margins, and the top of the tail.

A description of medications developed from an earlier form of the medication. First generation medications were developed from the original form of the drug; second generation medications are adaptations of first generation drugs; third generation drugs are adaptations of second generation, etc.

The faster and greater immune response produced by an animal who has previously encountered that specific antigen. Memory cells are responsible for this more efficient response. Also called 'anamnestic response.'

(SSRIs), Selective serotonin reuptake inhibitors: Medications which slow down the ability of nerve cells to absorb serotonin, a neurotransmitter (chemical that serves as a messenger between nerves). Example: Prozac.

A behavioral condition in which the pet becomes anxious when separated from the owner. Dogs with separation anxiety tend to 'shadow' their owners, greet them exuberantly when they return after being gone, and sometimes vocalize, chew destructively, and urinate or defecate when separated from their owners.

A disease affecting many organ systems due to toxins in the blood which are released by bacteria or other microorganisms. Signs include fever, pinpoint bruises on mucous membranes, and lesions in the joints, heart valves, eyes, or other organs.

Shedding (of organisms): A term used to describe the release of organisms (bacteria, protozoa, viruses) into the environment from an infected animal. The organisms may be in the stool, urine, respiratory secretions, or vaginal discharges. The 'shedding' animal may or may not be showing symptoms of disease.

A condition in which the blood glucose level increases if too much insulin is given. It occurs when insulin causes the blood glucose level to go so low it stimulates the production of other hormones in the body such as epinephrine, which promote the breakdown of glycogen (the chemical compound which the body uses to store glucose) and increases the blood glucose level above normal. It is also called rebound hyperglycemia or insulin-induced hyperglycemia.

A ring-like band of muscle that constricts a passage or closes an opening, e.g., the anal sphincter constricts to close the anus and relaxes when the animal is passing stool. The urethral sphincter closes the urinary bladder.

Part of the immune system of an animal. A large, tongue-shaped organ in the abdomen containing many lymphocytes. The spleen filters blood and removes damaged cells. It can also manufacture new blood cells if the animal's bone marrow is damaged.

Selective serotonin reuptake inhibitors: Medications which slow down the ability of nerve cells to absorb serotonin, a neurotransmitter (chemical that serves as a messenger between nerves). Example: Prozac.

A condition in which the heart beats very rapidly because of signals coming from the atria (chambers of the heart that receive the blood) or near the junction of the atria with the ventricles (the chambers of the heart that pump the blood to the body or lungs).

Producing effects similar to the 'flight or fight' response, which means the body is alerted to a danger of some sort and prepares to basically run or fight. Sympathomimetic effects include increased heart rate, sweating, and increased blood pressure.

Also called 'T lymphocytes.' The type of lymphocyte which is responsible for cell-mediated immunity. T cells may directly kill a cell or produce chemicals called lymphokines that activate macrophages which will kill the cell. Compare with 'B cell.'

A description of medications developed from an earlier form of the medication. First generation medications were developed from the original form of the drug; second generation medications are adaptations of first generation drugs; third generation drugs are adaptations of second generation, etc.

A lower than normal number of platelets in the blood. Platelets, which are actually fragments of specific types of cells, are necessary for blood to clot. Signs of thrombocytopenia include bruising and bleeding from the nose, into the gastrointestinal tract, etc.

Hormone produced by the hypothalamus that stimulates the pituitary gland to produce thyrotropin (thyroid stimulating hormone-TSH), which in turn stimulates the thyroid gland to produce thyroid hormone. Also called TSH releasing factor or TSH releasing hormone.

A measurement of the amount of antibodies in the blood. The test to measure antibodies is usually performed by making a number of dilutions of the blood and then measuring at what dilution there is sufficient antibody to react in the test. For example, a titer of 1:8 (one to eight) means the blood can be diluted to one part blood and seven parts saline and still produce a positive reaction in the test. The higher the titer (1:16 is higher than 1:8), the more antibody is present. (NOTE: The word 'titer' may also be used when discussing the amount of antigen present, e.g., a high titer vaccine has a large number of virus particles.)

A class of antidepressants which work by decreasing the amount of certain chemical transmitters taken up by specific nerve cells. The tricyclic antidepressants include clomipramine, amitriptyline, and nortryptyline and are often used to treat behavioral problems in small animals.

A type of diabetes mellitus in which although the blood glucose levels are higher than normal, they are not immediately life-threatening, and the animal can survive without supplemental insulin. Also called non-insulin dependent diabetes mellitus (NIDDM).

A term often used to describe a condition in which an animal who was vaccinated against a disease still gets the disease. In truth, there is usually nothing wrong with the vaccine, but for some reason, the animal's immune system did not adequately react to it.

Either of two large veins carrying blood to the right atrium of the heart. The cranial vena cava brings blood from the head region, front legs, and upper chest to the heart; the caudal (or posterior) vena cava carries blood from the areas of the abdomen and hind legs to the heart.

Cells in the blood whose major role is to defend the body against invading organisms such as bacteria, viruses, and fungi. There are different types of leukocytes: lymphocytes are part of the immune system; monocytes, eosinophils, and neutrophils eat or engulf organisms; basophils contain histamine and are involved in inflammatory reactions.