HD2: Plants possess a family of HDAC proteins, the HD2 family, which is not found in animals or fungi and is distantly related to cis-trans isomerases found in insects, S.cerevisiae and parasitic apicomplexans. Using maize HD2 as a query, four candidate proteins, HDT1, HDT2, HDT3 and HDT4, were identified in the Arabidopsis proteome. The conserved N-terminus of these proteins contains the HD2-type HDAC domain of approximately 100 amino acids. The proteins are comprised of a conserved N-terminal domain, a central acidic domain and variant C-terminal domain. (1)