Brown characterized the first steroid hormone receptor co-activators which serve as the 'missing link' connecting hormones-and receptors to gene transcription. His work illuminated the chromatin context by which steroid receptors activate tissue-specific patterns of gene expression and their importance in breast and prostate cancer.

Research Interests

The primarily focus of the work in my laboratory is the molecular understanding of the action of nuclear receptor transcription factors and their roles in prostate and breast cancers. My lab identified the p160 class of nuclear receptor interacting proteins and showed that these coregulators play an important role in the tissue and promoter selective action of steroid receptors and their ligands.

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