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A study produced by four research institutions in Brazil combines two 3D printable polymers into structures ideal for cell-growth. Known as cell scaffolds, these structures are used in regenerative medicine; i.e. repairing the damage to human organs by using the body’s own cells.

3D printing and electrospinning

PCL is commonly used in 3D printing as it is biodegradable and has a low melting point. PLGA is a copolymer often used to make medical devices. Both plastics are approved for non-toxic compatibility within the body by the FDA.

In this study, 3D printed PCL is coated with PLGA using an electrospinning technique. The benefit of electrospinning is that it doesn’t require high temperatures to control a liquid polymer. It also blocks any harmful solvents from entering into a finished object.

Discs of PCL are 3D printed on a custom made 3D printer. One batch of the discs then get coated in PLGA giving them a woven, microscopic finish.

All discs are then laced with stem cells, and monitored for the ability to culture cells. By comparison to PCL alone, PLGA coated PCL promotes better cell attachment due to the varied porosity of the surface.

In addition, the researchers were able to coat both sides of the scaffold to create denser tissue. The authors explain,

A different approach of seeding cells on both sides of the scaffolds was used with the aim of increasing cell density. Thus, it is possible to have stem cells on both sides of the scaffold when transplanting this material to injured tissue, presumably accelerating the regeneration time.

Beau Jackson is Senior Journalist at 3D Printing Industry. With a longstanding commitment to the site's content, she is credited with producing more articles than any other author in its history. Well-versed in the latest 3D printing research and legal/regulatory challenges, her repertoire spans aerospace, automotive, maritime, medical and creative industries. She is a keen speaker and active representative of the company at key additive manufacturing events.