Archive for the ‘Health’ Category

Yesterday for the first time I read this quote written on the bottom of a sign inside Boulange Bakery on Union St (SF) — it was right above the counter with sugar, jam, cream, nutella, etc. Although I had visited the same bakery and spread raspberry preserves on my croissant there numerous times before, I had not noticed the quote until now — pure genius. We often look externally for happiness — is it social, cultural, economic, or geographic? Or is it really just as simple as deciding to be happy?

Denmark is the happiest nation and Zimbabwe the the most glum, he found. (Zimbabwe’s longtime ruler Robert Mugabe was sworn in as president for a sixth term Sunday after a widely discredited runoff in which he was the only candidate. Observers said the runoff was marred by violence and intimidation.) The United States ranks 16th…. “The results clearly show that the happiest societies are those that allow people the freedom to choose how to live their lives,” Inglehart said.

Happiness is 50 percent genetic, says University of Minnesota researcher David Lykken. What you do with the other half of the challenge depends largely on determination, psychologists agree. As Abraham Lincoln once said, “Most people are as happy as they make up their minds to be.”… One route to more happiness is called “flow,” an engrossing state that comes during creative or playful activity, psychologist Mihaly Csikszentmihalyi has found. Athletes, musicians, writers, gamers, and religious adherents know the feeling. It comes less from what you’re doing than from how you do it.

The youtube video on this site interviewing Dr. Langer is cool… he shows how drug delivery via polymers is now leading to precise targeting of drugs down to the unicellular level and enabling release of drugs controlled by human-embedded microprocessors.

In choosing his career in 1974, he blew off the oil companies and talks about how his first boss liked to hire unusual people. He invented 200 ways that it didn’t work for every 1-2 successful ways that did.

Children’s thinking differs from that of adults, and people tend to view those differences as deficits that need to be overcome-the sooner the better. Bjorklund argues, though, that some aspects of children’s immature cognition are actually adaptive, both in preparing them for adulthood and in allowing them to flourish in childhood. He gives several examples: Children typically overestimate their own abilities, which may maintain their motivation in the face of failure and lead to eventual success. Their limited information-processing capacity may help them learn language, because it forces them to focus on constituent components and build upward from there, whereas adult language learners skip straight to semantics, often failing to master underlying grammatical structures. And play in childhood may promote later social competence, as neuroscientist Sergio Pellis has demonstrated in rats.

Bjorklund finds implications that will interest parents and educators. Parents often want their children to be the first among their peers to reach every developmental milestone, but Bjorklund points out that earlier is not always better and may sometimes be worse.

For example, abnormally early visual experience in birds disrupts development of the auditory system. Also, in a classic study published in American Scientist in 1959, “The Development of Learning in the Rhesus Monkey,” psychologist Harry Harlow found that the ability of rhesus monkeys to discriminate objects on various dimensions such as shape was impaired by starting the training too early in life—the monkeys who started training at older ages reached higher peak levels of performance. In a 1977 study by developmental psychologist Hanus Papousek, human infants who started learning to turn their heads to specific sounds at 31 days of age mastered the task, on average, at 71 days of age, whereas infants who started learning to do so at birth did not master the task, on average, until the age of 128 days.

Bjorklund’s message is that human development takes as long as it does for good reasons and that experiences should be introduced only when children are cognitively ready for them. Early education should foster a love of learning, which will pay dividends in the long run, rather than a fear of falling behind, which increases stress and decreases motivation. He acknowledges that schooling is necessary for success in the modern world and that direct instruction is sometimes useful. But as much as possible, he believes, we should let children enjoy childhood. We should even seek to maintain some “immature” qualities, such as curiosity and playfulness, into adulthood. As Aldous Huxley observed, “The secret of genius is to carry the spirit of the child into old age, which means never losing your enthusiasm.”

This may be a contributing factor to why Finnish kids by age of 15 — who start school 2-3 years later at age 7 than students in other countries — outperform their peers on international standardized tests conducted by the OECD.

“If we can spend the early decades of the 21st century finding approaches that meet the needs of the poor in ways that generate profits for business, we will have found a sustainable way to reduce poverty in the world,” Mr. Gates plans to say….

To a degree, Mr. Gates’s speech is an answer to critics of rich-country efforts to help the poor. One perennial critic is Mr. Easterly, the New York University professor, whose 2006 book, “The White Man’s Burden,” found little evidence of benefit from the $2.3 trillion given in foreign aid over the past five decades.

Mr. Gates said he hated the book. His feelings surfaced in January 2007 during a Davos panel discussion with Mr. Easterly, Liberian President Ellen Johnson Sirleaf and then-World Bank chief Paul Wolfowitz. To a packed room of Davos attendees, Mr. Easterly noted that all the aid given to Africa over the years has failed to stimulate economic growth on the continent. Mr. Gates, his voice rising, snapped back that there are measures of success other than economic growth — such as rising literacy rates or lives saved through smallpox vaccines. “I don’t promise that when a kid lives it will cause a GNP increase,” he quipped. “I think life has value.”

Brushing off Mr. Gates’s comments, Mr. Easterly responds, “The vested interests in aid are so powerful they resist change and they ignore criticism. It is so good to try to help the poor but there is this feeling that [philanthropists] should be immune from criticism.”

Easterly is former research economist at the World Bank now at NYU. in his book he looks at the successes/ failures of international aid interventions (financial + military) by “The West” and makes the case that they have done more harm than good during the past 50+ years.

Most of Easterly’s book makes sense to me and I agree with Easterly that philanthropic/aid agencies are not “above” criticism – their hyped up expectations do not necessarily make things better and sometimes they make things worse by standing in the way of more realistic, lasting solutions… but,

I agree with Gates on one thing, that you can get into trouble measuring national economic development using aggregate GDP (growth) instead of measuring the purchasing power of the bottom pyramid (half or quarter) of earners in the economy. Easterly cites India as a success story of development showing a chart of exponential GDP growth over 20-40 years using the Indian IT industry as an example. Despite this progress, the failure is that 50 years after Indian independence close to half of all Indians (400-500 million people) still live on less than $1 of $2 per day.

Easterly says new (niche) market creation is limited by social and legal barriers to trust and property rights and therefore must take place indigenously – there is not much we can do about it living in “The West.” I think we have not yet explored the potential of the Internet to overcome these constraints and help diversify agricultural economies (long tail). See my essay “Opening Niche Markets in Rural India using the Internet”

Style. Though his analysis is very compelling and data-driven with graphs, stories of people, case studies of developing nations, and world history, to me the title seems a bit polarizing or stuck in the past and the tone of the writing is funny bit also feels a bit sarcastic. Perhaps it is discouraging to visionaries and optimists who want to break from the past. In his book he takes aim at Bono and Jeffery Sachs’ “The End of Poverty.”

I tried to capture the main ideas of the book… sure I missed something but I think it’s mostly here.

— Top-down “planners” at large institutions like the World Bank will mobilize resources on the basis of utopian agendas and large-scale “big pushes” that attract donor governments and private institutions (in US, UK, and The West). These visions are never achieved because they lack feedback from the people (Africa, Asia, and “The Rest”) whom they are intended to benefit, i.e. the poor. On the other hand, he notes that the World Bank produces very high quality economic research.

— Unlike market-driven firms or (legitimately) elected officials the planners are accountable to donors, not the poor. planners’ jobs are not dependent on serving the poor but rather to indulge donors’ unrealistic expectations which may never materialize. The “planners” efforts do more harm than good (large part of what the book is about). The failures of these big pushes become self-fulfilling as donors redouble their efforts, bureaucracy becomes bloated, and they begin to measure progress based on volume of aid disbursed not impact on the poor. incentives of planners and poor people are not sufficiently aligned – this is called the principal-agent problem

— Bottom-up “searchers” (NGOs, entrepreneurs, profit-seeking companies) who are on “the ground” in developing countries can get direct feedback from the poor people they serve and make real impact on the their lives. they set realistic, achievable goals unlike the planners. Too little money is going to support the searchers. several case studies.

— On microfinance and microcredit,

Microcredit is not a panacea for poverty reduction that some have made it out to be after Yunis’ discovery. Some disillusionment with microcredit has already come in response to these blown-up expectations. Microcredit didn’t solve everything; it just solved one particular problem under on particular set of circumstances-the poor’s lack of access to credit except at usurious rates from moneylenders.

— Markets are a spontaneous outgrowth of social trust (for transactions) and property rights (for investment), and can’t be planned by aid agencies, foreign governments, or “out of the blue” after an invasion or removal of a dictator.

— Foreign aid has been most effective and made a large-scale impact in people’s lives for things like vaccination, health care delivery, and programs to keep kids/girls in school when compared to other areas in which results can’t be directly measured. dollar for dollar, the recent momentum to offer AIDS treatment ($1000 per person) like Bush’s $15 billion commitment of US taxpayer funds for Africa (30 million infected) is many times less cost-effective compared to preventing the spread of AIDS through condoms (600 million not infected) or even prevention of other life-threatening diseases like malaria, diarrhea, and infant mortality. the spread of AIDS could have been avoided had prevention been a bigger priority since experts have been predicting this epidemic for over a few decades. In AIDS, saving a life gets more “emotional” attention from the public than prevention of AIDS transmission which could save many more lives.

— There have been some success stories, but economic growth in developing countries has not been correlated to aid/intervention by the West. Colonialism and imperialism has resulted in long-term economic stagnation, which he offers as a case study to consider other neo-imperialistic plans to take over weak-states. His claim is that countries develop much faster and better when they are left to their own.

— National financial health has less direct impact on earnings of the poorest people, except indirectly via inflation and government subsidies to the poor.

The IMF’s approach is simple. A poor country runs out of money when its central bank runs out of dollars. The central bank needs an adequate supply of dollars for two reasons. First, so that residents of the poor country who want to buy foreign goods can change their domestic money (let’s call it pesos) into dollars. Second, so those poor-country residents, firms, or governments who owe money to foreigners can change their pesos into dollars with which to make debt repayments to their foreign creditors. What makes the central bank run out of dollars? The central bank not only holds the nation’s official supply of dollars (foreign exchange reserves), it also makes loans to the government [aside from foreign borrowing with bonds] and supplies the domestic currency for the nation’s economy. The government spends the currency [it borrows], and the pesos pass into the hands of people throughout the economy. But are people willing to hold the currency? The printing of more currency [excessive government borrowing from the Central Bank] drives down the value of currency if people spend it on the existing amount of goods – too much currency chasing too few goods… so they take the pesos back and exchange them for dollars. The effect of printing more currency that people don’t want is to run down the central bank’s dollar holdings. Too few dollars for the outstanding stock of pesos is kind of like the Titanic with too few lifeboats. The country then calls on the IMF. So the standard IMF prescription is to force contraction of central bank credit the government, which requires a reduction in the government’s budget deficit [government spending]… forces the government to do unpopular things [like cut subsidies] – disturbance of domestic politics.

— Bad governments (corruption and violent dictators) have been responsible for much of the slow growth in these countries, which are in turn caused by either a colonial past or by historical poverty itself. Foreign aid tends to prop these governments up, and in some cases private organizations working around these governments can lead to much better results.

— Loans are not necessary to balance a national budget, and the IMF’s prescriptions for foreign exchange lending to developing countries and reducing government spending can be way off. This is due to severe accounting irregularities in the books of these countries, uncertainty of how or when markets react to falling currency prices, and how they react to information in the economy (people’s behavior). Lending based on shaky foundations can lead to the self-reinforcing “debt trap” through repeated refinancing of poor countries and propping up of bad governments. the IMF does better in emerging markets, but he says it may be better off to leave the poorest countries alone.

It’s based on research/experiments with hundreds of subjects over several years involving psychological surveys, fMRI, blood tests, and the like. Also seems this applies to mammals of all sorts. Fun to read all the way through.

Three stages (lust, love, attachment)

Lust is characterized by sexual attraction to the opposite sex, and driven primarily by testosterone regardless of gender

Love is defined by focus/obsession with one mate in particular, mediated by dopamine and norephrenine. when the “mate” is not presentthe rise in dopamine/norephrenine causes a drop in serotonin, just like an addiction/depression.

Attachment is creates the sense of peace/solace/trust in a long term relationship and occurs primarily due to oxytocin in females and vasopressin in males.

According to the book there are interactions between these three effects (for example attachment may suppress lust), with evolutionary explanations.

A study of Swedish twin brothers found that differences in a gene modulating the hormone vasopressin were strongly tied to how well each man fared in marriage.

“Our main finding was an association between a variant of the vasopressin receptor 1a gene and how strong bonds men reported they had to their partners,” said lead researcher Hasse Walum, of the department of medical epidemiology and biostatistics at the Karolinska Institute in Stockholm. “Men carrying this variant scored on average lower on a scale measuring the strength of the bond compared to men not carrying this variant.”

Women married to men carrying the “poorer bonding” form of the gene also reported “lower scores on levels of marital quality than women married to men not carrying this variant,” Walum noted.

Vasopressin activates the brain’s reward system, and “you could say that mating-induced vasopressin release motivates male voles to interact with females they have mated with,” Walum said. “This is not a sexual motivation, but rather a sort of prolonged social motivation.” In other words, the more vasopressin in the brain, the more male voles want to stick around and mingle with the female after copulation is through. This effect “is more pronounced in the monogamous voles,” Walum noted.

They found that men with a certain variant, known as an allele, of the vasopressin 1a gene, called 334, tended to score especially low on a standard psychological test called the Partner Bonding Scale. They were also less likely to be married than men carrying another form of the gene. And carrying two copies of the 334 allele doubled the odds that the men had undergone some sort of marital crisis (for example, the threat of divorce) over the past year.

All that said, the article tries to balance explaining the threat with the paranoia

Many common organisms can be dangerous or even deadly: Some 3,000 germs are known to cause human illness, says John Sinnott, director of Infectious Disease and International Medicine at the University of South Florida and Tampa General Hospital.

Even so, trying to wipe out all of the bacteria in your house isn’t advisable, experts say. Science writer Jessica Snyder Sachs, author of “Good Germs, Bad Germs,” says 99.9% of all germs are harmless to humans, and some are even beneficial. “Our bodies are covered with microbes, and many protect us against the bad guys,” she says.

Anually, over 90,000 people in the US or 32 per 1000 are infected with antibiotic drug resistant strains of bacteria (‘Superbug’ Poses Threat). It seems now more people die from a hospital-acquired form of drug resistant bacteria called MRSA than AIDS (More U.S. Deaths From MRSA Than AIDS) — 18,000 versus 16,000.

While the researchers, health care, and drug companies figure a way out of this there are a few things we can do to prevent infection from these strains…

In this op-ed in the Wall Street Journal, a doctor and former FDA official is calling for increased efforts to detect and defeat the drug-resistant strains of bacteria before it becomes an epidemic (“Attack of the Superbugs”).

We’ve all heard someone say that, but now it seems neuroscientists have found out why — lack of sleep causes us to misinterpret environmental cues and interactions as threatening or harmful. Read more in this newspaper article “The science of sleep deprivation.”