TY - JOUR
T1 - Interval mapping of multiple quantitative trait loci.
JF - Genetics
JO - Genetics
SP - 205
LP - 211
VL - 135
IS - 1
AU - Jansen, R C
Y1 - 1993/09/01
UR - http://www.genetics.org/content/135/1/205.abstract
N2 - The interval mapping method is widely used for the mapping of quantitative trait loci (QTLs) in segregating generations derived from crosses between inbred lines. The efficiency of detecting and the accuracy of mapping multiple QTLs by using genetic markers are much increased by employing multiple QTL models instead of the single QTL models (and no QTL models) used in interval mapping. However, the computational work involved with multiple QTL models is considerable when the number of QTLs is large. In this paper it is proposed to combine multiple linear regression methods with conventional interval mapping. This is achieved by fitting one QTL at a time in a given interval and simultaneously using (part of) the markers as cofactors to eliminate the effects of additional QTLs. It is shown that the proposed method combines the easy computation of the single QTL interval mapping method with much of the efficiency and accuracy of multiple QTL models.
ER -