Abstract

One series of novel substituted 3-(2-indoloyl)-3-phenylprop-2-en-1-one were synthesized by a base catalyzed Claisen-Schmidt condensation reaction of 3-Acetyl indole with different halogen substituted benzaldehydes. Synthesized chalcones were converted into pyrazoline derivative by
reacting with hydrazine hydrate. All the compounds were purified by recrystallization and characterized by 1HNMR, 13CNMR and MS spectroscopy. Synthesized compounds were screened for its anti-inflammatory activity by membrane stabilization method. These compounds showed effective
stabilization of RBC membrane and can become a promising leads for the development of new antiinflammatory agents in future.