Table 1

Cell-line unique CTCF binding events are biased towards genes that are differentially
regulated in the corresponding cell line, with respect to other cell lines.

Genes adjacent to cell-line unique CTCF peaks

Genes Differentially Expressed

MCF10A

MCF-7

ZR75-1

MCF10A

p = 4.652e-14

p < 2.2e-16

p = 0.5983

MCF-7

p = 0.06637

p < 2.2e-16

p = 0.4189

ZR75-1

p = 0.5536

p < 2.2e-16

p = 0.002955

The number of genes differentially expressed in each cell line, with respect to both
other cell lines, but not in the other cell lines with respect to each other; the
number of genes within 20 kb of a cell-line specific CTCF binding site; and the p-values
from Fisher's exact test of the overlaps between those sets. The universe of genes
is the 24, 928 distinct genes present on the Illumina gene expression arrays used
in the experiment.