EAST LANSING, Mich. -- The Cleveland Cavaliers will head into their preseason finale against the Detroit Pistons on Friday night shorthanded.

Larry Nance Jr. suffered a sprained right ankle during Thursday's practice. He will be out for the final exhibition game and re-evaluated over a period of several days. Isaiah Taylor, one of the training camp standouts, will also be sidelined for a little while with a stress fracture in his left leg.

According to the Cavaliers, Nance will undergo a period of treatment and rehab over the next several days and his status will be updated when appropriate. There's no word on his availability for the regular season opener on Oct. 17 in Toronto.

Expected to rotate with Tristan Thompson as the team's starting center this season, Nance's setback paves the way for Ante Zizic to start Friday night against Detroit.

Taylor, who came to camp on a non-guaranteed deal in hopes of landing the final roster spot, was experiencing pain in his lower left leg.

He underwent an MRI at Cleveland Clinic earlier Thursday and the results revealed a stress fracture. Like Nance, Taylor will undergo a period of rest, treatment and rehab before returning to basketball activities. A timeframe for that return has not been established.

In three preseason games, Taylor averaged 4.6 points on 6-of-17 from the field and 0-of-1 from 3-point range to go with 2.3 assists.