Here is one good possiblity for her parents: Sgt. James Thompson and (Nancy) Ann Perry. I’ve not seen primary source information about this couple, so this is not necessarily correct: he was born in Scotland, served in the Revolution in the Maryland Line (he is in the DAR lineage volumes), moved to Virginia, and then to Kentucky. She was from Prince George’s Co., Maryland, or from Rhode Island. They had 8 children (born in MD or VA) before moving to Bracken Co., KY. Their third child was named Margaret. Since there weren’t likely to be many Margaret Thompsons in Bracken Co. at the time, this makes it possible. But the birth dates differ: James and Ann’s Margaret was born on 26-Sept-1772, which obviously differs from what I have here.

I know that this is out there on the web, but there's a problem here with dates.

And, note what the following discussion passes on about the Thompsons, a discussion of my Margaret in the context of a grandson (via Maria):

"The Doctor's [i.e., Dr. Elijah Currens Dimmitt] mother was born in Bracken county, the daughter of William and Margaret (Thompson) Currens. William Currens started the tannery just north of the town of Germantown, in Bracken county, ran the business successfully and continued in the same operation until his death, in 1844, at which time Robert P. Dimmitt was in charge as manager and closed up the business. The Thompsons were millers in former generations and French in genealogical descent. They built a number of mills in different states and some members of the family now reside in Indiana."

One source that might help with this family: Edward Thomson, The annals of the Strene or Strean family : including the Thomson annals. The index of this volume at the FHL says that it includes work on the Currens family as well, so this might be a help.

Several members of a Thompson family are buried at Maple Grove Cemetery in Germantown, Kentucky. [2]