17 Feb 2011: Report

Climate’s Strong Fingerprint In Global Cholera Outbreaks

For decades, deadly outbreaks of cholera were attributed to the spread of disease through poor sanitation. But recent research demonstrates how closely cholera is tied to environmental and hydrological factors and to weather patterns — all of which may lead to more frequent cholera outbreaks as the world warms.

by sonia shah

Since cholera first erupted from India’s Ganges delta in 1817, the bacterial pathogen has swept across the globe in no fewer than seven worldwide pandemics, afflicting hundreds of millions of people and killing more than 70 percent of its victims within hours if left untreated.⁠ The seventh pandemic — the longest one yet — began in Celebes, Indonesia in 1961, and has spread to more than 50 countries and 7 million people.⁠ That pandemic continues to this day, staking its latest beachhead in earthquake-ravaged Haiti, where a cholera epidemic occurred last year after a reported absence of some 100 years.

Historically and in the modern popular imagination, cholera has been considered a disease of filth carried in sewage. And yet, over the past decade, research on cholera’s natural habitat and links to the climate have revealed a revolutionary new understanding of the disease as one shaped just as much by environment, hydrology, and weather patterns as by poor sanitation. And as temperatures continue to rise this century, cholera outbreaks may become increasingly common, with the bacteria growing more rapidly in warmer waters.

The University of Maryland cholera expert Rita Colwell, a former director of the National Science Foundation, pioneered the study of Vibrio cholerae, the bacteria that causes cholera, in the environment. She and

others have discovered the bacteria in water bodies untouched by human waste, its abundance and distribution fluctuating not with levels of contamination, but with sea surface temperature, ocean currents, and weather changes. After several centuries during which cholera’s spread has been attributed solely to human activity, it has been paradigm-shifting research. “Thirty years ago, we were ridiculed to even say that the bacterium existed in the environment,” Colwell says. “But now it is in textbooks. The evidence is so overwhelming, it is understood.”

While cholera epidemics are caused by multiple factors, of which environmental influences are just one, Colwell and other experts are closely monitoring the potential impact of global warming on the diarrheal disease. “Although there is no clear understanding of the exact nature of the relationship between cholera and climate,” says Tufts University cholera expert Shafiqul Islam, “if climate change leads to more extremes, it will have an impact on cholera.” In fact, it may already have. Over the past 30 years, El Nino events in the Bay of Bengal — characterized, in part, by warmer sea surface temperatures — have increased, paralleling a rise in cholera cases in Bangladesh. The World Health Organization calls it “one of the first pieces of evidence that warming trends are affecting human infectious diseases.”

The growing understanding of the role that climate plays in cholera outbreaks has sparked disagreement between environmental scientists, such as Colwell, and the medical community. While many cholera researchers concur that these environment influences play an important role in the incidence of cholera, especially in places such as Bangladesh and India, most hail from medical fields, which continue to emphasize the role of human activity in the spread of the disease. Scientists such as Matthew Waldor, an infectious disease expert from Harvard University, worry that characterizing cholera outbreaks as a result of environmental influences undermines efforts to prevent the disease using vaccines and other methods.

NASA

Phytoplankton blooms, like this one in the Bay of Bengal, are one way that scientists can forecast cholera outbreaks.

“There is an inevitability to the environmentalist arguments about cholera,” he says. “If cholera travels by the environment... then it is not preventable.” Whereas linking cholera outbreaks to human activity, he says, reinforces the indisputable — and uncontested — truth that preventing cholera requires changing human activity.

And yet, new research on cholera’s links to the environment may help minimize cholera’s damage in other ways. The macro-environmental factors that drive cholera can be tracked using remote sensing data and other forecasting methods, opening up the possibility of an early warning system for cholera. Islam is among several scientists developing methods to use remote sensing data to track the coastal plankton blooms that presage cholera outbreaks. Satellite data on chlorophyll concentrations, a discernible proxy for zooplankton levels, can successfully predict cholera incidence, too. NOAA recently funded the development of a system to predict levels of Vibrio cholerae in the Chesapeake Bay using data on the bay’s changing salinity and surface temperature.

In fact, cholera surveillance teams from the World Health Organization (WHO) have already used El Nino forecasting to help prepare communities for potential cholera outbreaks, including one in Mozambique in 1997, predicted by the WHO based on forecasts of El Nino-related drought in southeast Africa.

What is clear is that populations of Vibrio cholerae in coastal waters, estuaries, and bays rise and fall in association with a range of environmental factors. In Peru, levels of cholera vibrio bacteria have been linked to the temperature of local rivers; in Italy, to the surface

In Bangladesh, cholera risk increases two to four times following a 5-degree C spike in the water temperature.

temperatures of estuaries along the Adriatic coast. In Mexico, the abundance of cholera vibrios in lagoon oysters rise as seas warm. In the Chesapeake Bay, Vibrio cholerae levels increase during the summer, as water temperatures spike. In Bangladesh, cholera risk increases by two to four times in the six weeks following a 5-degree C (9-degree F) spike in the water temperature⁠. Likewise, in Ghana, an analysis of 20 years of data revealed a correlation between cholera incidence and rainfall and land surface temperatures. In Djibouti, Somalia, Kenya, Mozambique, and Tanzania, cholera epidemics have been correlated with flooding as well as sea surface temperatures.

Global climate drivers such as the El Nino Southern Oscillation and the Indian Ocean Dipole appear to be similarly linked to the incidence of cholera. The El Nino Southern Oscillation — in which warm waters build up in the central and eastern Pacific and the Indian Ocean — creates extreme weather conditions, including floods. El Nino cycles have occurred for centuries, but some scientists believe they will become more frequent and will intensify as the world warms.

Scientists from the University of Michigan and the University of Barcelona analyzed 70 years of data on cholera prevalence in Bangladesh, finding an association between cholera incidence and increasingly intense El Nino events that began in 1980. Statistical modeling by scientists at the University of Santiago de Compostela in Spain found a correlation between the pattern of pathogenic vibrio infections in Peru with El Nino events, a relationship experts suspect may be responsible for a massive cholera outbreak in Peru that occurred during El Nino events in 1991.

Predicted changes to the climate thanks to global warming may intensify these effects. A 2003 WHO study warned that predicted warming of African lakes, such as Lake Tanganyika, may increase the risk of cholera transmission among local people, and that countries such as Tanzania, Kenya, Guinea-Bissau, Chad, Somalia, Peru, Nicaragua, and Honduras —

‘We could again see epidemics of cholera in the U.S. and Europe that we haven’t seen in 100 years,’ says one expert.

which suffered major cholera outbreaks after heavy rains in 1997 — may face more cholera epidemics as the climate changes.

Climate change-driven storms, flooding, and heavy rainfall may lead to the spread of cholera in other ways, too. “Extreme weather events can lead to a breakdown in sanitation, sewage treatment plants, water treatment systems,” says Colwell. “And indeed, because the bacteria are part of the natural environment, we could again begin to see epidemics of cholera in the U.S. and in Europe that we haven’t seen in almost a hundred years.”

Climatic and hydrological changes lead to cholera outbreaks by creating the ecological conditions in which cholera vibrios thrive. While Vibrio cholerae has been found free-living in aquatic environments, and clinging to fish, insects, and waterfowl, they are most often found in association with widely dispersed zooplankton called copepods. The vibrios attach to the carapace and guts of copepods, where they replicate and ultimately cover the surface of the female copepod’s egg sack.⁠

Warm, nutrient-rich water helps promote cholera vibrio growth because it leads to phytoplankton blooms, and within a week or two, corresponding spikes in copepods and other zooplankton that feed on phytoplankton.⁠ Droughts can promote the growth of cholera vibrios by increasing salinity in local waters, which helps Vibrio cholerae attach to copepods, while floods help distribute the bacteria more widely. Climatic and environmental changes may alter the local species composition of copepods, some of which may play a bigger role in hosting cholera vibrio than others, says Colwell’s collaborator, the microbiologist Anwar Huq.

The scientific debate over the relative role of the environment in shaping cholera recently flared into political controversy in the wake of the devastating outbreak in Haiti. Enraged rioters in Haiti blamed the United Nations’ Nepalese peacekeepers and leaky sewage pipes at their camps for contaminating the country with cholera.

Experts such as Harvard’s Waldor agree. “This strain [in Haiti] came from very, very far away,” Waldor says. He was part of a team that found genetic similarities between the strain of cholera in Haiti and ones in South Asia. “If you have the same genomic sequence in two different places like continents, the most likely explanation is that human beings brought one strain to the

‘Cholera cannot be defeated by medicine alone — we need a new approach,’ one scientist says.

next,” Waldor says. “That goes back hundreds of years in the history of cholera. Ships from one part of Asia brought it elsewhere... It was spread by humans.”

Colwell doesn’t think so. “To ascribe outbreaks solely to introductions externally is not what modern ecological data tell us,” she says. “The data we’re gathering for the last 40 years show that these bacteria are part of a natural aquatic environment, and the molecular genetic evidence now accumulating is pretty convincing that the outbreaks are local. You can have it introduced, but the big outbreaks are generally local.”

In Haiti, Colwell says, the earthquake washed silt and limestone into the river system, creating the nutrient-rich, alkaline conditions that cholera vibrios thrive in, just as an extremely warm summer set in. Rising concentrations of cholera bacteria coincided with an explosion of malnourished refugees with little access to treated water. It’s a series of events that has triggered cholera outbreaks before, she says.

Colwell points out that the genetic analysis of the strain in Haiti is complicated by the fact that cholera vibrio are genetic rogues, with many mobile elements in their genomes, and the Haiti strain, while genetically similar to a South Asian strain, is also similar to one found in East Africa.⁠ According to Colwell, more research will be required to unravel the true origins of Haiti’s cholera. The trouble is that the very idea of environmentally driven outbreaks “is resisted by the medical community,” she says. “But this is new data. And it is typical, when you produce a new hypothesis, it takes years for acceptance.”

With nearly $800 billion in drugs sold worldwide, pharmaceuticals are increasingly being released into the environment. The “green pharmacy” movement seeks to reduce the ecological impact of these drugs, which have caused mass bird die-offs and spawned antibiotic-resistant pathogens.READ MORE

“Physicians are not trained in ecology,” says Colwell, who has taught in medical schools. And yet, “in the twenty-first century of emerging disease, the source is the environment, and animals in the environment... Epidemiology really needs to take into account the ecology of microbial systems.”

That’s not to say that the old truths don’t still hold true. “This is a disease of poverty,” says Islam. The solution, he says, is simple: Clean drinking water, good sanitation, and vaccines prevent the disease, and prompt rehydration treatment and antibiotics cure it.

But with the environment changing, the disease on the move, and poverty still entrenched in many parts of the world, “cholera cannot be defeated by medicine alone,” he adds. “We need a new approach.”

COMMENTS

Good Article.

I agree with the many points raised. Here is more to add to the issue.

Climate Change Increases Cholera Cases In Africa, Study Suggests
ScienceDaily (Apr. 27, 2009) — A study led by researchers from the Madrid Carlos III Institute of Health associates the increase of cholera cases in Zambia with climatic factors. For the first time, the results confirm that the increase in environmental temperature six weeks before the rain season increases the number of people affected by this sickness by 4.9%.

"This is the first time that it has become evident in the sub-Saharan region that the increase in environmental temperature is related to the increase in cholera cases," explains Miguel Ángel Luque, one of the study's authors and researcher from the Madrid Carlos III Institute of Health (ISCIII), to SINC. Previous studies in Bangladesh already associated the cases with an increase in ocean surface temperature.

Dr.A.Jagadeesh Nellore(AP), India

Posted by
Dr.A.Jagadeesh
on 17 Feb 2011

Very informative article.

I wasn't aware there was a vaccine for cholera. I wonder why vaccination wasn't part of the
immediate response to the Haitian crisis-or was it? It would seem vaccinations could have been given at feeding sites.

I know vaccination is a primary objective of the Gates Foundation at the moment-did they get involved?

Posted by
Lawrence Nachsin
on 22 Feb 2011

This is a very intriguing article. With epidemics, the immediate cause might be singular (exposure to a virus/bacterium/parasite), but the forces which come together to produce and sustain outbreaks are complex and interconnected, and require similarly interdisciplinary solutions.

Incidentally, the article was sent to my by a medical researcher, who found the ideas interesting and worth thinking about.

http://globalhealth.unc.edu

Posted by
Lisa Chensvold
on 22 Feb 2011

Sonia, well done again, your article is very informative indeed. The different hypothesis indeed need to be proven. The Haiti phenomenon seem to fall within the current "evidence based'
explanation than going around witch hunting.

evidence of association is not "causal" so the issue of environmental, hydrological may eventually be a week angle to explain about cholera. With similar tools and an understanding of our environment, here in Zimbabwe we were able to trace and know where and how we eventually had a devastating Cholera outbreak in 2006-2008. Elnino or no Elnino

Good luck with your adventure into science and its related diseases.

Posted by
Prof. Lovemore Gwanzura
on 23 Feb 2011

My compliments, Sonia, on your excellently researched and presented article on the possible relationship between climate and the epidemiology of cholera.

The current problem with this age-old scourge in Haiti provides an invaluable example of the long-unrecognised influence that major features of climate change can impose on the international spread of this versatile pathogen.

A further major problem with Vibrio cholerae is the rapidity with which it can evolve genetic mutations that enhance its virulence, thus limiting our ability to provide effective vaccines.

Posted by
Wallace Peters
on 23 Feb 2011

I very much enjoyed this well written and well researched article. I find the power of prediction of cholera transmission by environmental factors as a major and exciting breakthrough in infectious disease control. I also agree with Waldor that we will have to continue to place emphasis on vaccine development and other interventions so that that critical effort is not undermined by the new technologies.

Posted by
Pardis Sabeti
on 23 Feb 2011

Interesting points, presented in a thorough and even-handed fashion. I'm puzzled by Professor Waldor's contention that acknowledging the environment as a factor in cholera's spread leads to the "inevitability" of a corresponding belief that cholera is not preventable. I would think the opposite to be true -- preventing the disease's spread can best happen only when all factors are accounted for in the public health response.

Posted by
Tom Kavanagh
on 23 Feb 2011

Excellent work. There are always multiple variables.

Posted by
navin sanghvi
on 24 Feb 2011

The article reports clearly and concisely a new hypothesis about propagation of infectious
diseases. It is very interesting for scientists, health providers and lay readers. If confirmed,
new measures of prevention need to be thought and put in place to contain the infectious agents.

Yet, it seems to me that vaccination still remains the best choice.

Posted by
Giampietro Corradin
on 25 Feb 2011

thanks for the link, sonia. Two points. ones;"cholera is a disease of poverty " is dead right, and because greenpeace failed to ban chlorine, countries like the USA are unlikely ever to be at risk. Two; the vaccine is very expensive, and not 100% effective.

Posted by
ian hilliar
on 28 Feb 2011

I really enjoyed the perspective presented by Ms. Shah on this article that contributes to awareness that disease (in this case cholera) is the result of multiple factors, not only that of the direct etiologic factor bacteria, but the environment and the host. I think that this is a well written and researched review, and provides a basis for an enligthened discussion, with many more questions to answer.

Posted by
Roberto Miranda
on 17 Apr 2011

Thanks so much for the article, it has helped me greatly in my research on cholera and climate change. I'm a community health and development student.

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