Androgyne is also sometimes used as a medical synonym for an intersex person.

It notes that there are no universally-accepted definitions, and terminology confusion is common because terms that were popular in at the turn of the 21st century may now be deemed offensive.The degree to which individuals feel genuine, authentic, and comfortable within their external appearance and accept their genuine identity has been called transgender congruence. Oliven of Columbia University coined the term transgender in his 1965 reference work Sexual Hygiene and Pathology, writing that the term which had previously been used, transsexualism, "is misleading; actually, 'transgenderism' is meant, because sexuality is not a major factor in primary transvestism." By 1992, the International Conference on Transgender Law and Employment Policy defined transgender as an expansive umbrella term including "transsexuals, transgenderists, cross dressers", and anyone transitioning.Leslie Feinberg's pamphlet, "Transgender Liberation: A Movement Whose Time has Come", circulated in 1992, identified transgender as a term to unify all forms of gender nonconformity; in this way transgender has become synonymous with queer.Transgender people are sometimes called transsexual if they desire medical assistance to transition from one sex to another.Transgender is also an umbrella term: in addition to including people whose gender identity is the opposite of their assigned sex (trans men and trans women), it may include people who are not exclusively masculine or feminine (people who are genderqueer/non-binary, e.g. transgender people may identify as heterosexual, homosexual, bisexual, asexual, etc., or may decline to label their sexual orientation.

people who meet Benjamin's definition of a "true transsexual" but do not desire SRS include Miriam Rivera.