In Hitman: Blood Money, Agent 47 finds himself in the midst of a war between two rival contract agencies. When assassins from his contract agency, the ICA, are systematically eliminated in a series of hits, it seems a larger, more powerful agency has entered the fray. Suddenly, Agent 47 loses contact with the ICA. Sensing that he may be the next target, he travels to America where he attempts to carry on with business as usual.