Authors:
Dhurat, Rachita1
Chitallia, Jill1
May, Theodor W.2
Jayaraaman, Ammani M.3
Madhukara, Jithendriya4
Anandan, Subbu5
Vaidya, Pradyumna6
Klenk, Adolf7 adolf.klenk@alcina.de
Source:
Skin Pharmacology & Physiology. Jan2018, Vol. 30 Issue 6, p298-305. 8p.
Document Type:
Article
Author-Supplied Keywords:
Anagen hairs
Androgenetic alopecia
Caffeine-based topical liquid
Frontal trichogram
Occipital trichogramAbstract:
Background: Androgenetic alopecia is a condition with a high prevalence worldwide and affects both males and females. Currently, only 2 approved treatments exist: finasteride (males only) and minoxidil 2 or 5% solution (males and females). Methods: We conducted a randomized, open-label, multicenter noninferiority study to determine whether a caffeine-based 0.2% topical liquid would be no less effective than minoxidil 5% solution in males (n = 210) with androgenetic alopecia. The primary end point was the percentage change in the proportion of anagen hairs from baseline to 6 months using a frontal and occipital trichogram. Results: At 6 months, the group of the 5% minoxidil solution showed a mean improvement in anagen ratio of the trichogram of 11.68%, and the group of the 0.2% caffeine solution had an anagen improvement of 10.59%. The difference of mean values between both groups was 1.09%. The statistical analysis was performed and reported in accordance with the CONSORT Guidelines 2010 for reporting of noninferiority and equivalence randomized trials. Conclusion: A caffeine-based topical liquid should be considered as not inferior to minoxidil 5% solution in men with androgenetic alopecia.