Saikrishna Prakash's scholarship focuses on separation of powers, particularly executive powers. He teaches Constitutional Law, Foreign Relations Law and Presidential Powers at the Law School.

Prakash majored in economics and political science at Stanford University. At Yale Law School, he served as senior editor of the Yale Law Journal and received the John M. Olin Fellowship in Law, Economics and Public Policy. After law school, he clerked for Judge Laurence H. Silberman of the U.S. Court of Appeals for the District of Columbia Circuit and for Justice Clarence Thomas of the U.S. Supreme Court. After practicing in New York for two years, he served as a visiting professor at the University of Illinois College of Law and as an associate professor at Boston University School of Law. He then spent several years at the University of San Diego School of Law as the Herzog Research Professor of Law. Prakash has been a visiting professor at the Northwestern University School of Law and the University of Chicago Law School. He also has served as a James Madison Fellow at Princeton University and Visiting Research Fellow at the Hoover Institution at Stanford University.

Among Prakash's articles are "How to Remove a Federal Judge" and "The Executive Power Over Foreign Affairs," published in the Yale Law Journal; and "Removal and Tenure in Office" and "Delegation Really Running Riot," published in the Virginia Law Review.

“Unoriginalism’s Law Without Meaning,” 15 Const. Comment. 329 (1998) (reviewing Jack Rakove, Original Meanings: Politics and Ideas in the Making of the Constitution (1998)).HeinOnline (PDF)

“General United States Tax Considerations Pertaining to the Creation, Acquisition and Disposition of Trademarks” (with Peter F. Riley), in Advanced Seminar on Trademark Law, 1996, at 403 (Practising Law Institute, 1996).