Inclusion Criteria:

- At least one episode of a SCD-related crisis or complication (e.g., vaso-occlusive
crisis, acute chest syndrome, priapism) per year for an average of 3 years or one
episode of acute chest syndrome over the prior 5 years

- If receiving hydroxyurea therapy, must be receiving a stable dose for at least 6
months

- Able and willing to give informed consent

- If female, must have a negative serum pregnancy test within 7 days of dosing

- If female, must not be of childbearing potential defined as post-menopausal by at
least 2 years or surgically sterile, or must agree to use a medically accepted form
of contraception throughout the study

- If the sexual partner of a male subject is a WCBP, she must agree to use a medically
accepted form of birth control for themselves or their partner throughout the study

- In the view of the Investigator, able to comply with necessary study procedures

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