Electrophysiological studies showed a significant increase in Cd(2 (zeige CD2 Antikörper)+) and manganese (Mn(2+)) currents through the CaV3.1 (zeige CACNA1G Antikörper) mutants as well as a reduction in the inhibitory effect of Cd(2 (zeige CD2 Antikörper)+) on the Ca(2 (zeige CA2 Antikörper)+) current.

Sperm with a near absence of CatSper current failed to respond to activation of CatSper by progesterone and there was fertilization failure at IVF (zeige SCN5A Antikörper).

The role of CATSPER1 in idiopathic asthenospermia pathogenesis: exonal SNP rs1893316 in CATSPER1 significantly correlated with idiopathic asthenospermia risk

This work reports the cloning and characterization of the promoter regions in the human and murine Catsper1 genes. The immediate upstream region and the first exon in the human CATSPER1 gene negatively regulate transcriptional activity. The mouse Catsper1 promoter exhibited transcriptional activity in both orientations and displayed significant expression levels in mouse testis in vivo.

CatSper is indeed the principal Ca2 (zeige CA2 Antikörper)+ channel of human spermatozoa, and that it is strongly potentiated by progesterone.

CatSper activation can elicit functionally different behaviors according to the sensitivity of the Ca(2 (zeige CA2 Antikörper)+) store, which may be regulated by capacitation and NO from the cumulus.

These results establish a critical role of LRRC52 in KSPER channels and demonstrate that loss of a non-pore-forming auxiliary subunit results in severe fertility impairment.

SLO3 (zeige KCNU1 Antikörper) K+ channels have a role in controlling calcium entry through CATSPER channels in sperm

Using mice lacking both SLO3 (zeige KCNU1 Antikörper) and CATSPER1 subunits, the results show conclusively that the voltage-activated outward current present in Slo3 (zeige KCNU1 Antikörper) (-/-) sperm is abolished when CATSPER is also deleted.

The mouse Catsper1 promoter exhibited transcriptional activity in both orientations and displayed significant expression levels in the mouse testis in vivo.

Immunization with B-cell epitopes in transmembrane domains and pore region of CatSper1 can cause significant antifertility effects in male mice.

Yijingfang can increase the sperm count and the expression of CatSper1.

CATSPER1 Antigen-Profil

Protein Überblick

Calcium ions play a primary role in the regulation of sperm motility. This gene belongs to a family of putative cation channels that are specific to spermatozoa and localize to the flagellum. The protein family features a single repeat with six membrane-spanning segments and a predicted calcium-selective pore region.