A rapid switch in sympathetic neurotransmitter release properties mediated by the p75 receptor.

Many neurons contain more than one neurotransmitter; for example, cultured sympathetic neurons can release noradrenaline as well as acetylcholine, which affect the beat rate of cardiac myocytes in opposite ways. This study reports on the remarkable observation that the release of either noradrenaline or of acetylcholine can be selectively regulated.

The former requires the activation of the tyrosine receptor TrkA, the latter, that...

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