Price attended Crenshaw High School in South Los Angeles where he had 85 tackles, 17 tackles for loss, 15 sacks, four forced fumbles, and two recovered fumbles while battling double and triple teams in 2006. As a junior, made 111 tackles, including 22 sacks. Price was named "Coliseum League Defensive MVP" consecutive times in 2005 and 2006. He was selected to play in the U.S. Army All-American Bowl.

Considered a four-star recruit by Rivals.com, Price was ranked No. 5 among defensive tackle prospects in the nation.[1] He picked UCLA over USC on March 11, 2006.

In 2006 Price played in the last 10 games of the season, with five starts. He earned Second-team Freshman All-America honors from Rivals.com and Scout.com and honorable mention from The Sporting News. He made the Sporting News Pac-10 All-Freshman team.

As a sophomore in 2007, Price led the Bruins with 14 tackles for loss. He was also second on the team with 4.5 quarterback sacks. He earned a First-team All-Pac-10 selection by the league's coaches, and a First-team Sophomore All-American selection by College Football News.[2]

Price was a starter in all 12 games in 2008. He was a First-team All-Pac-10 selection by the league's coaches and ESPN.com ... First-team Sophomore All-American by collegefootballnews.com. He led the team with 14.0 tackles for loss (12 in the last nine games) and was second on the team with 4.5 sacks.

Price started 12 games in 2009 and made 43 tackles (22.5 for losses) and seven sacks. He also forced two fumbles and recovered one and deflected a pass. He was a First-team All-American by the AFCA and a consensus All-Pac 10 selection,.

After UCLA's win in the 2009 EagleBank Bowl, Price announced his decision to forgo his final year of eligibility and enter the 2010 NFL Draft.[6] He was taken by the Tampa Bay Buccaneers with the 3rd (35th overall) pick in the 2nd round.

During Week 13 of the 2011 NFL season, against the Carolina Panthers, Price shoved Panthers guard Mackenzy Bernadeau well after the end of a third-quarter play in which Cam Newton was sacked for a four-yard loss. Price was penalized for unnecessary roughness. The sack would have forced the Panthers into a 3rd-and-14 situation. However, the resulting 15-yard penalty gave the Panthers a first down, allowing them to complete a touchdown drive that put the game out of reach (the Panthers won 38-19). Buccaneers coach Raheem Morris was so incensed that he banished Price from the sideline for the rest of the game.[7] The move drew comparisons to then San Francisco 49ers coach Mike Singletary banishing Vernon Davis from the sideline after a personal foul in 2008.[8] Price was also reported to have had an altercation with teammate Mark Barron during a team meeting in 2012.[9]

On July 26, 2012, Price was traded to the Chicago Bears for a 7th round draft pick.[9][10] The Bears waived Price on September 3, 2012.[11] On December 20, 2012, Price was brought in by the Minnesota Vikings for a workout.[12]

Price grew up in South Los Angeles, where gang violence was a frequent occurrence. Two of his brothers, Eddie and Damon, were killed in gang-related shootings in Crenshaw. He also has six sisters.[14] In May 2012, his sister Bridget, 30, died as a result of a car accident in Inglewood.[15][16]