The choice to support or fight the Superhuman Registration Act provides unique aspects to gameplay. For example, if you pick Captain America, you might get some help from the Punisher; whereas if you choose Iron Man, you may earn help from the Thunderbolts. Both sides contend for the allegiance of heroes still making up their minds, such as Spider-Man, Spider-Woman and Ms. Marvel.

Civil War features amazing slow-motion combat animations Iron Man and Captain America, each battling for what they see is right. The number of followers amassed to each cause determines the difficulty of each fight, as determined by striking the proper targets and ramps, some of which materialize in thin air.