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The laminar airflow component is related to the linear ascendant portion of the airflow versus time relationship, and this portion remained similar between non-stimulated and stimulated cycles. The effects of TMS on maximal inspiratory flow and inspiratory volume became apparent after the rise of airflow owing to the time required for corticobulbar tract depolarization and the contraction Sitaxentan of the upper airway dilator muscles (Melo-Silva et al. 2013), and one should expect that TMS should modify the turbulent airflow component in the same way. In this sense, we found a decrease in the turbulent airflow component after the third stimulated cycle, indicating an improvement of airflow pattern after two single consecutive TMS-induced twitches. Moreover, the effects of TMS-induced twitch in the airflow pattern ceased immediately after TMS interruption, which ratifies the hypothesis of a TMS-induced recruitment of upper airway dilator Afatinib muscles on airflow dynamics and corroborates the fact that the effects of single-pulse TMS protocols (even applied consecutively) on airflow dynamics are not sustained in time. In summary, we demonstrated that consecutive stimulation of the submental muscles by TMS with the stimulator output set at sleep SUBMT enhances the airflow dynamics of flow-limited respiratory cycles and may arouse a minority of patients from sleep. The mechanical effects of such very brief stimuli applied repeatedly during inspiration using different stimulation protocols will bring new insights to the potential of central stimulation of upper airway muscles to improve upper airway loading during sleep. None declared. Canadian Institutes of Health Research, Grant 89985. ""Follicular helper T (TFH) cells and B cells are linked to the pathogenesis of ankylosing spondylitis (AS). Follicular regulatory T (TFR) cells suppress TFH cell and germinal center B cell numbers in vivo. The role of TFR cells in AS is unknown. The frequency of peripheral blood inducible FOXP3+CXCR5+CD4+TFR cells and CXCR5+CD4+TFH cells were taken from 20 onset AS patients and 10 healthy controls, and were examined by flow cytometry, their disease activity were measured by the bath ankylosing spondylitis disease activity index(BASDAI). CAL-101 nmr The concentrations of serum IL-21, IgG, IgA, IgM, CRP were examined, and the values of eESR were measured. The frequency of peripheral blood FOXP3+CXCR5+CD4+TFR cells, CXCR5+CD4+TFH cells, the ratio of FOXP3+CXCR5+CD4+TFR/ CXCR5+CD4+TFH cells, and the concentration of serum IL-21 in the AS patients were significantly higher than those in the HC (p<0.0001, p=0.0027, p<0.0001, p=0.0039, respectively). The frequency of FOXP3+CXCR5+CD4+TFR cells and the ratio of FOXP3+CXCR5+CD4+TFR/ CXCR5+CD4+TFH cells still significantly rose in those patients after standard treatment (p=0.0006, p<0.0001), the concentration of serum IL-21 decreased after treatment (p=0.</div>