EAST RUTHERFORD, N.J. -- The New York Giants are going to have to make changes on their offensive line for the second time in as many days.

The Giants announced Wednesday that David Diehl will need surgery to repair an unstable right thumb. The 32-year old was hurt in Sunday's preseason game vs. Indianapolis and is expected to be sidelined six weeks.

The surgery will come one day after Diehl was moved from right tackle to left guard in the wake of an injury to center David Baas. Left guard Kevin Boothe moved to center and first-round draft pick Justin Pugh played right tackle.

Boothe could move back to guard and Jim Cordle could play center. Or, Boothe could stay put and Cordle or Brandon Mosley or James Brewer could take over at guard.

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The Giants (1-1) will meet the Jets (1-1) on Saturday.

Diehl practiced on Tuesday with a cast on his right hand, and didn't seem concerned, saying he has done that before.

After an MRI and examination by Dr. Robert Hotchkiss Wednesday morning, it was determined the injury required surgery.

"Obviously Dave's injury is a tough one," Boothe said before practice. "If anybody can play through it, Dave can. For it to be that significant, it's something that needed attention now. We'll regroup. Unfortunately we've had experiences of guys going down and we'll respond."

The bottom line, however, is that the Giants might enter the season opener at Dallas Sept. 8 with two new players on the offensive line.

Boothe said change is something offensive linemen expect. During the 2011 Super Bowl season, he said he started at three different positions in three weeks because of injuries.