For Serena Williams to lose her bid for the calendar-year Grand Slam, another player would have to step up and beat her, something that hasn't happened at a major in more than 14 months. While there will be 127 potential candidates for the role of vanquisher, there are few obvious choices. Serena has no rival—no Nadal to her Federer—nor has any one colleague played the burr in her saddle and vexed her. Still, before the making of the U.S. Open draw, here are five potential spoilers.

It's going to be one wild ride for Jimmy Garoppolo. He isn't the first quarterback from Eastern Illinois playing for big stakes (Tony Romo), but there's a reason—a bunch of them—that Bill Belichick drafted him higher than he has any other QB since he came to New England