REFERENCE INTERVAL ADOPTION IN 3 STEPS IS POSSIBLE WITH LARGE AND ROBUST STUDIES, SUCH AS CALIPER.1

CALIPER (the Canadian Laboratory Initiative on Paediatric Reference Intervals) is an independent, robust paediatric reference interval study in healthy children.This study is a multicenter project to develop complete and accurate paediatric reference intervals, including those for alkaline phosphatase. The CALIPER study was conducted independently of Alexion Pharmaceuticals, Inc.The CALIPER ALP reference interval data are a rich resource for laboratories worldwide, and are applicable to all 5 major instrument platforms--Abbott, Beckman Coulter, Ortho, Roche, and Siemen.2

Update interpretation of test results and lab reports, including appropriate flags and comments3

Developing pediatric reference intervals locally is challenging, so most laboratories use published data.4 This approach can be reliable with data from large, robust, well-documented studies such as CALIPER.4