About Propofol

Propofol is used as a short-acting substance in general anesthesia. It is used to initiate and maintain the mindset and sedation of patients undergoing intensive ventilation or undergoing special examinations or operations.

What is the purpose of this ingredient?

Align brain cells in the cerebral cortex

hinder communication between brain parts

Turn off consciousness

This is how Propofol works

Below you will learn more about the fields of application and the mode of action of Propofol.
Please also read the information on the drug groups to which the drug Propofol belongs.

Applications of the active substance Propofol

Propofol is used as a short-acting substance in general anesthesia. It is used to initiate and maintain the mindset and sedation of patients undergoing intensive ventilation or undergoing special examinations or operations.

Depending on the field of application, Propofol is used alone or together with analgesics of local or general effect.

Propofol can only act on the bloodstream and is therefore given solely as an injection or into the vein.

For the following application areas of Propofol , in-depth information is available:

Action of Propofol

Propofol is used in anesthesia surgery. However, it has no analgesic and no muscle-relaxing effect. Propofol must therefore be combined with analgesics and, if necessary, with muscle relaxants for painful procedures.

The most likely mechanism of action today is thought to be that propofol massively alters the basic activity of the cerebral cortex. The drug appears to interfere with communication between different brain areas by “matching” a large number of nerve cells (neurons). This synchronization prevents signals from being sent from the cerebral cortex to other brain regions. This ultimately breaks down information processing in the cortex, which could be the key to the controlled loss of consciousness.

Propofol acts quickly and quickly and is available only in the form of syringes. Already 10 to 20 seconds after the injection the effect comes in and lasts with only one application only eight to nine minutes. The effect can be sustained by continuous infusion or repeated dosing with smaller doses.

Dormicum is no longer effective with frequent use, it will require higher dosages, which can then no longer be responsible by the doctors. Propofol causes an extreme burning sensation when injected into the vein, with frequent use also higher doses necessary until it becomes effective. (Experience after 150 operations under general anesthesia)

Today I had a short-term anesthetic with propofol and also terrible burning in the vagina as the drug spread throughout the body. I knew that the medication was on fire. That this burning can still occur in the vagina was new to me. Good only that shortly thereafter began to sleep.

I received Propofol to initiate an ITN in a neck surgery. After i.v. When I was falling asleep, I immediately felt a flush of heat throughout my upper body and felt my eyes would always flicker from left to right (like fixing objects out of a moving vehicle, such as trees). Both were not particularly unpleasant, but I have clearly remembered. (In the recovery phase, I became latent with no vomiting, which lasted for several hours, but I blamed this side effect more on an i.v. dose of Dipidolor I got for pain relief.)

I had a minor surgery that could have been performed on an outpatient basis (ateroma on the back). Even as the plunger of the syringe pushed the fluid into me, I felt a pleasant sensation of relaxation. I could still say to the sister: It’s a great stuff, so you could earn much more behind the train station. When I woke up after the operation, I was immediately fully there and went to the clinic park after 10 minutes without any gear insecurity or circulatory problems. For the evening I visited with my wife a good restaurant. But I still had a completely unexpected effect: my depression, which affect me very much my life, were completely gone (!) For 3 days. I can not explain that, it may also have been due to the simultaneously administered ketamine.

My mother had to have a bronchoscopy done with Propofol and almost did not survive it. After a seizure with respiratory arrest and near-cardiac arrest she found herself in the intensive care unit. Luckily, she only had to be ventilated for a few hours. I read that propofol is extremely difficult to dose properly. So, whoever is small and tender like my mother should be careful !!!

Had hallucinations (sometimes quite abstract with shapes and colors and with cosmonautsuit flying through space) … so I imagine the effect after taking drugs. During the operation, I did not feel / perceived and even after the anesthesia or the waking up no negative side effects have occurred. Except for a Lachflash … I thought waking up was just funny because of the memories of crazy hallucinations / dreams.

Propofol got over 2 days after surgery to heal the most severe symptoms. In anesthesia everything was ok, at least I have no memory of it. The awakening that lasted for more than 3 days was very violent: from completely white ‘screen’ in front of the eyes to shocking near-death experiences with the most violent, abstract hallucinations, which went into my deepest inmost everything was there. Even after the full attainment of consciousness, I had some sort of ‘stutter perception’ for several days, i. both optical and acoustic stimuli came patting my brain every half second. But with these experiences I seem to be quite an exception. Propofol seems to be more pleasing to other patients. Unfortunately, I can not confirm that.

I had to have a stomach and a colonoscopy done. Actually, I did not want anesthesia, because I’m always afraid that my blood pressure sags and I faint (unfortunately, has occurred more often). In the hospital, I was then but urgently advised to anesthetic: that would be no proper anesthesia and there would be no problems after the anesthesia. And because I’m currently being treated for hypertension, that would not happen. So I agreed. I would never do that again. Sure, the introduction was very simple, my cycle was downright catastrophic. I was gone within two seconds – and as dizzy as I was, I might have fainted too. Waking up was a disaster. I was so dizzy lying down that I could not even recognize the blanket correctly or focus. It was not possible to lift my head. This only improved very slowly within the next two hours. When lying down, the blood pressure was normal, standing up, he was no longer measurable. Never again, I can only say. Under normal circumstances, I have too high a blood pressure, and so on. Sorry, I can only say: Stay away from this narcosis form. Fortunately, I was in the hospital so I could lie down for a long time. Nevertheless, one could or did not want to do anything about the low blood pressure.

I got Propofol as a reassurance in my gastroscopy! Since I had severe anxiety because of endoscopy, the doctors gave me twice the dose! That was fatal, because I’m 1,60m small and weigh 50 kg. After waking up, I was in a kind of trance and fog for weeks. I collapsed after a few days, with respiratory depression and sleep disturbances. This drug has thrown me out of life, it took me weeks to get along and not to be afraid!

In a toothpop propofol was used in my case. At first I was almost not awake, then I was dog-suffering and I had extremely violent migraine with vomiting for 3 days etc. I had not had such migraines in the whole life yet. I will take care at the next surgery that the remedy will not be used again.

I’ve got propofol for colonoscopy and worked quite well. Only after I woke up, I was very dizzy and had severe nausea. Then, thank goodness got what against the nausea. I slept again 4 hours at home and after I had eaten and drunk again, it went again reasonably

I got propofol as a sedation in a status epilepticus. I was allergic to it with a very high fever, respiratory arrest which led to an intubation and the status read thereby also not interrupt! Consequence: 1 day in ICU, mechanically ventilated, artificially fed and bladder catheter. Other side effects after waking were / are dizziness, tiredness, gait insecurity, difficulty with speech, headache, severe joints! As sedation with propofol in a status epilepticus deffinitive not recommended!

Can only recommend Propofol! You get the injection and is gone immediately …. Even after waking up, there were no complaints – only a slight lingering tiredness – Conclusion: Do not be afraid of a gastroscopy, easy going with this anesthetic! Was really afraid of the many negative reports (but without stunning!) Of my acquaintances.

mild circulatory problems For me, propofol was used as an anesthesia in a colonoscopy. I can not remember anything about the investigation, not even falling asleep. I woke up sometime in the recovery room. Was then a little tired all day and had very low blood pressure, which led to initial circulatory problems. However, this subsided within a few hours and is certainly also with other anesthetics and possibly not even due to the Propofol, but due to the 1.5-day eating ban before the investigation. But otherwise there were no side effects. I would recommend Propofol 100% as a sedation in a colonoscopy – especially in anxiety patients like me!