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The Notch pathway is a highly conserved, ubiquitous signaling system that regulates a wide variety of cellular processes from cell fate decisions to tissue patterning and morphogenesis. Given that almost all structures in the body plan require Notch signaling at some point in their development, it is not surprising that defects in components of the Notch signaling pathway have been found associated with certain inherited diseases and cancer. The research in Dr. Gerry Weinmaster's laboratory seeks to understand the molecular mechanisms by which Notch signaling is induced and regulated by using a combination of cellular and animal model systems.