We are currently performinng a serie of pilot experiments to generate TALENs-based gene knockouts for an initial set of 10 selected genes. TALENs design and synthesis is performed by specialised TEFOR-associated platform "TALGENE".
Mutations are generated by TALEN-induced double-strand DNA break followed by Non-Homologous End Joining.
We expect to open TALEN-based gene knockout service in 2014.

Below are few schemes presenting TALENs function, TALEN assembly and an example of identification/mapping of TALEN-induced mutations in flies.