Details for anatomical structure: pituitary gland of diencephalon

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Synonyms

General information

A small oval shaped unpaired endocrine gland suspended from the base of the hypothalamus by a short extension of the infundibulum, the infundibular or pituitary stalk, it consists of two major subdivisions, the neurohypohysis and the adenohypophysis

SDF-1-alpha /CXCL12 causes both proliferation and growth hormone release, suggesting that the activation of CXCR4 may represent a novel regulatory mechanism for growth hormone secretion and pituitary cell proliferation, which may contribute to pituitary adenoma development. [4]

In female ER alpha knock out mice, disruption of the negative feedback actions of estradiol in the hypothalamic-pituitary axisresults in elevated levels of the gonadotropin subunit mRNAs in the pituitary and in serum LH. [6]

Influences:

SDF-1-alpha /CXCL12 causes both proliferation and growth hormone release, suggesting that the activation of CXCR4 may represent a novel regulatory mechanism for growth hormone secretion and pituitary cell proliferation, which may contribute to pituitary adenoma development. [4]

Influences:

In female ER alpha knock out mice, disruption of the negative feedback actions of estradiol in the hypothalamic-pituitary axisresults in elevated levels of the gonadotropin subunit mRNAs in the pituitary and in serum LH. [6]

Induced phenotype:

In an in vitro study using pituitary cells obtained from female rats in different days of the estrous cycle, it was observed that thymulin modulates the stimulatory activity of gonadotropin-releasing hormone on LH and follicle-stimulating hormone (FSH) release. [13]

There is in vitro and in vivo evidence suggesting that thymulin plays a role in the regulation of female spontaneous puberty, possibly through effects on pituitary gonadotropin release and ovarian steroidogenesis. [17]

Induced phenotype:

Induced phenotype:

Influences:

...stimulatory effect of CST on PRL release is exerted through a receptor not shared by SST...it has been reported that CST(...)binds with high affinity to GHS-R1a(...) which in turn is known to stimulate PRL secretion [19]