Abstract

The present research paper has been focused on synthesis of nalidixic acid mannich base derivatives by adopting appropriate synthetic steps with expected broader spectrum of activity. Purification of intermediates and final titled compounds has been done by recrystallization. Characterization of all the synthesized mannich derivatives including intermediates by physical and spectral data like IR, Proton NMR and elemental microanalysis. Biological evaluation of the newly synthesized compounds for their pharmacological activity has been studied and found that the synthesized compounds are active against tested Gram positive and Gram negative bacteria like Satphylococcus aureus, Bacillus subtilis Escherichia coli and proteus, also active against tested fungilike Candida albicana and Candida tropicalis by adopting standard protocols.