Opening Odds & Line MovementOpen: -4.5 -105 at Pinnacle
The NFL odds opened up with the Bills as 4.5-point favorites as the away team in London, and the time difference and travel makes it difficult to handicap games in London. The line moved to -4 before going back to -4.5, and it could move anymore after the injury report comes out. To be fair, it would probably be higher if it was actually held in Jacksonville as they're the home team, but with the travel to London, both teams are on more of a level playing field....in theory, anyway.

Injuries
The line could move more towards the Jaguars anyway as Buffalo continues to have a slew of injuries. DT Kyle Williams is out with a leg injury and might not be back after their bye week, which follows this game. WR Percy Harvin's hip is acting up, while WR Sammy Watkins called for more targets and is now hurt and unlikely to play on Sunday. Another WR, Marquise Goodwin, has a rib injury, while RB Karlos Williams has no idea what is going on with his concussion. However, QB Tyrod Taylor looks to be ready to go after missing the Cincinnati game with a knee injury.

For the Jags, WR Allen Robinson is dealing with a leg injury and will be evaluated later this week, while TE Julius Thomas hurt his ribs. Other than that, Jacksonville is healthy, but that doesn't seem to matter. They're a bad team, but getting better in some aspects, especially QB Blake Bortles.

Trends
The Bills have covered the spread in eight of their last 12 games, while Jacksonville are 8-15-2 ATS in their last 25. The total is at 42, and the Jags have gone over in four of their last five games, while Buffalo has gone over in three of their last five.

Buffalo has won three of their last five meetings with the Jaguars overall, covering the spread in four of those games. Home and roar records won't mean much with both teams playing in London.