- Uncontrolled hypertension. Blood pressure must be ≤160/95 mmHg at the time of
screening on a stable antihypertensive regimen. Blood pressure must be stable on at
least 3 separate measurements on at least 2 separate days.

- Uncontrolled infections (> grade 2 NCI-CTC version 4.0).

- Pregnant or breast-feeding women. Women of childbearing potential must have a
negative pregnancy test performed within 7 days of the start of treatment. Both men
and women enrolled in this trial must agree to use adequate barrier birth control
measures (e.g., cervical cap, condom, and diaphragm) or intrauterine device during
the course of the trial. Oral birth control methods alone will not be considered
adequate on this study, because of the potential pharmacokinetic interaction between
study drug and oral contraceptives. Concomitant use of oral and barrier
contraceptives is advised.

- Concurrent anticancer chemotherapy, immunotherapy or investigational drug therapy
during the study or within 4 weeks of the start of study drug.

- Concomitant use of dexamethasone, anti-convulsants and anti-arrhythmic drugs other
than digoxin or beta blockers.

- Severe allergy for contrast media not controlled with premedication.

- Substance abuse, medical, psychological or social conditions that may interfere with
the subject's participation in the study or evaluation of the study results.

- Any condition that is unstable or could jeopardize the safety of the subject and
their compliance in the study.

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