Susan and Michael Schofield have no letup in their grueling day –- 11-year-old Jani is one of the youngest children ever to be treated for schizophrenia, and now her 6-year-old brother Bodhi, though not officially diagnosed with the same disorder, has violent outbursts and self-harming behavior that suggest he might also have the disease.

“I had thought I had seen it all,” Michael Schofield, a 38-year-old part-time college professor, told ABC News. “What could possibly be worse than a young daughter in a psychiatric hospital?”

Their son has been diagnosed with severe autism and intermittent explosive disorder and has had five hospitalizations at a UCLA psychiatric facility this year, his parents said.

“The first challenge is you’re not sure your children are going to make it,” said Schofield. “Right now, we are afraid Bodhi will crack his skull open or at least severely injure himself. With Jani, there was the fear of suicide after she made a couple of attempts. It’s a threat to the basic survival of your children.”

The Los Angeles couple, who have been married since 1994, went public with their story to highlight the struggle of parents raising children with mental illness. They have devoted their entire lives to keeping their family together and not sending their children to a psychiatric institution. But the strain is taking a toll.

“There is a significant divorce rate in at least 75 percent of couples in these situations,” said Susan Schofield, 44, an Internet radio show host. “With hardly any respite care, there have been problems in our marriage. We haven’t been out on a date in 15 weeks. There just isn’t enough support out there.”

The Schofields’ difficult journey with Jani has been highlighted by Discovery Fit & Health television in several episodes since 2010. On May 26 during the network’s “Psych Week,” a sequel, “Born Schizophrenic: Jani and Bodhi’s Journey,” will air.

When Jani was younger she had visual and auditory hallucinations –- rats that she named “Wednesday” and cats named “midnight” and little girls named “24 hours.”

Jani is now on medication and making great progress, but Bodhi is not, the Schofields said. Mental illness runs in both sides of the family.

Dr. Mark DeAntonio, who is treating Bodhi, said the boy has “something different” than his sister.

“What led us to Bodhi’s diagnosis was she was having auditory and visual hallucinations that were bizarre and morbid,” he said in the documentary. “It was a fantasy world animals lived in.’

“Bodhi’s behaviors and psychiatric issues are consistent with someone who has autism,” said DeAntonio. “He has episodes of severe agitation and self-harm and there is no clear reason why he is falling down and hurting himself, biting himself. It’s most distressing.”

His mother is convinced Bodhi will eventually get a similar diagnosis as Jani. “I believe it will come out later as basically schizophrenia with a lot of autistic traits.”

Childhood schizophrenia is rare, according to psychiatrist Dr. Igor Galynker, director of the Family Center for Bipolar at Mount Sinai Beth Israel in New York City. Fewer than 1 percent of all cases start in childhood.

“Having two children with COS is probably even more rare by an order of magnitude,” said Galynker, who did not treat Jani.

Schizophrenia onset before age 13 is characterized by behavioral and cognitive symptoms that overlap with features of autism spectrum and disruptive behavior disorders, according to a 2007 article in Psychiatric Times. Early diagnosis is important to maximize treatment.