Summary

Description

Summary

This is a Phase 1 study is to visualize biodistribution of a PET tracer called [18F]F-AraG (VisAcT) in cancer patients expected to undergo immunotherapy.

Official Title

Study of the Kinetics, Dosimetry and Safety of [18F]F-AraG (VisAcT), a Positron Emission Tomography Tracer for Imaging the Activation of the Immune System in Cancer Patients Expected to Undergo Immunotherapy

Details

This is an exploratory Phase 1, prospective study assessing the biodistribution and radiation dosimetry of the Positron Emission Tomography [18F]FAraG (VisAcT) in cancer patients selected for immunotherapy. Each patient may have up to two [ 18F]FAraG PET imaging sessions, a baseline image and a post start of immunotherapy image. For each imaging session, patients will receive a single injection of [ 18F]FAraG and undergo up to four whole-body PET scans in the same day. Blood samples may be collected at up to 9 time points post-injection to analyze whole-blood/plasma time activity of [18F]FAraG. Following each imaging session, we will also assess safety in each subject. Blood pressure, heart rate, pulse oximetry, temperature, and respiratory count measurements as well as an electrocardiogram (ECG) recording will be taken prior to imaging, and after whole-body PET scans are completed.

Keywords

Cancer

Eligibility

You can join if…

Open to people ages 18–65

Cancer patients with identified tumor mass

Cancer patients expected to undergo immunotherapy

You CAN'T join if...

Under the age of 18

Pregnant women

Women who are breastfeeding

Individuals with known or suspected substance abuse

Individuals unable or unwilling to comply with the study procedures

Patients currently receiving immunotherapy treatment

Location

UCSF Imaging Center at China Basinaccepting new patientsSan Francisco, California, 94107, United States