Internationalization and effectuation share a common problem space because they both include Knightian uncertainty ("it is impossible to calculate probabilities for future consequences"), goal ambiguity ("preferences are neither given nor well ordered"), and environmental isotropy ("it is not clear what elements of the environment to pay attention to and what to ignore") (Sarasvathy 2008, p.

The issue of radiation exposure in multi-slice spiral CT is beyond the scope of this letter, but the question should be posed in principle: Under which conditions is the enhanced X-ray exposure caused by crossings of beam trajectories with repeated exposure of the same tissue areas compensated by the advantages of multi-slice spiral CT, such as isotropy and high resolution volumetric data?

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