STRING allows inspection of the interaction evidence for any given network. Choose any of the viewers above (disabled if not applicable in your network).

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:query proteins and first shell of interactors

white nodes:second shell of interactors

Node Content

empty nodes:proteins of unknown 3D structure

filled nodes:some 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

lolD

Lipoprotein release ABC transporter ATPase; Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (228 aa)

Predicted Functional Partners:

IL1518

Lipoprotein release ABC transporter permease (409 aa)

0.999

IL1516

Lipoprotein release ABC transporter permease (411 aa)

0.999

lolA

Outer membrane lipoprotein-sorting protein; Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (200 aa)

a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1

node2

node1 accession

node2 accession

node1 annotation

node2 annotation

score

IL0466

IL2265

IL0466

IL2265

RND efflux system membrane fusion protein

ABC transporter permease

0.939

IL0466

lolD

IL0466

IL1517

RND efflux system membrane fusion protein

Lipoprotein release ABC transporter ATPase; Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner

0.874

IL0466

tolC

IL0466

IL1957

RND efflux system membrane fusion protein

Outer membrane protein

0.826

IL0601

IL2265

IL0601

IL2265

RND family efflux system membrane fusion protein

ABC transporter permease

0.939

IL0601

lolD

IL0601

IL1517

RND family efflux system membrane fusion protein

Lipoprotein release ABC transporter ATPase; Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner

0.874

IL0601

tolC

IL0601

IL1957

RND family efflux system membrane fusion protein

Outer membrane protein

0.816

IL1294

IL2265

IL1294

IL2265

Hypothetical protein

ABC transporter permease

0.939

IL1294

lolD

IL1294

IL1517

Hypothetical protein

Lipoprotein release ABC transporter ATPase; Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner

0.874

IL1294

tolC

IL1294

IL1957

Hypothetical protein

Outer membrane protein

0.834

IL1516

IL1518

IL1516

IL1518

Lipoprotein release ABC transporter permease

Lipoprotein release ABC transporter permease

0.977

IL1516

lolA

IL1516

IL0666

Lipoprotein release ABC transporter permease

Outer membrane lipoprotein-sorting protein; Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)

0.977

IL1516

lolD

IL1516

IL1517

Lipoprotein release ABC transporter permease

Lipoprotein release ABC transporter ATPase; Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner

0.999

IL1518

IL1516

IL1518

IL1516

Lipoprotein release ABC transporter permease

Lipoprotein release ABC transporter permease

0.977

IL1518

lolA

IL1518

IL0666

Lipoprotein release ABC transporter permease

Outer membrane lipoprotein-sorting protein; Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)

0.975

IL1518

lolD

IL1518

IL1517

Lipoprotein release ABC transporter permease

Lipoprotein release ABC transporter ATPase; Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner

0.999

IL2057

IL2265

IL2057

IL2265

Membrane-fusion protein

ABC transporter permease

0.939

IL2057

lolD

IL2057

IL1517

Membrane-fusion protein

Lipoprotein release ABC transporter ATPase; Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner

0.874

IL2057

tolC

IL2057

IL1957

Membrane-fusion protein

Outer membrane protein

0.764

IL2265

IL0466

IL2265

IL0466

ABC transporter permease

RND efflux system membrane fusion protein

0.939

IL2265

IL0601

IL2265

IL0601

ABC transporter permease

RND family efflux system membrane fusion protein

0.939

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Network Stats

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Functional enrichments in your networkNote: some enrichments may be expected here (why?)

Enrichment analysis is still ongoing, please wait ...

Statistical background

For the above enrichment analysis, the following statistical background is assumed: