With no returning starters on the defensive line Jefferson was expected to be a mainstay for USC in 2016. But after starting in the opener against Alabama and accumulating 3 total tackles, Jefferson never saw the field again. He suffered a sprained shoulder against the Crimson Tide and later returned to his home in Las Vegas for what was described as "personal reasons."

Jefferson has not practiced with the team since returning from Dallas for the opener.

In late September head coach Clay Helton announced the he would hold out Jefferson until November in order for him to catch up on academics.

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