The development of ultrasensitive, anti-jamming, and durable sensors that can precisely distinguish different human body motions are of great importance for smart health monitoring and diagnosis. Physical implementation of such flexible sensors is still a challenge at the moment. Combining the designs of advanced material showing excellent electrochemical properties with the facilitative structure engineering, high-performance flexible sensors that satisfy both signal detecting and recognition requirements may be made possible. Here we report the first metal-organic framework-based strain sensor with accurate signal detection and noise-screening properties. Upon doping the tricarboxytriphenyl amine-based metal-organic framework nanofilm with iodine, the two-terminal device exhibits ultrahigh sensitivity with a gauge factor exceeding 10,000 in the 2.5% to 3.3% deformation range for over 5000 dynamic operating cycles and out-of-scale noise-screening capability. The high-performance strain sensor can easily differentiate the moderate muscle hyperspasmia from subtle swaying and vigorous sporting activities.