Westmore was nominated for an Academy Award for the makeup for Star Trek: First Contact. He had already won the award for 1985's Mask (shared with Star Trek Nemesis makeup artist Zoltan Elek). Spanning the years 1988-2005, Westmore was nominated for an Emmy Award every year the spin-off television series franchise was in production, the only Star Trek staffer to do so. Receiving on several occasion two nominations in a particular year, his total was 24 nominations, of which he won five. Apart from his Star Trek work, he also garnered in those years additional Emmy Award nominations for the television series and movies Highway to Heaven, David (both in 1988), Babe Ruth (1992), and Geppetto (2000), bringing his grand total of nominations to 28.

In addition, Westmore has the distinction of becoming one of the very few Star Trek staffers in any function, to have officially served uninterrupted for the full eighteen years on the entire production run of the modern television franchise, having worked on all series and movies produced during that era (excepting Star Trek V: The Final Frontier and Star Trek VI: The Undiscovered Country, due to his commitments to The Next Generation) at one time or another.

With 31 award wins and nominations for his work on the franchise, Michael Westmore is by far the most honored Star Trek staffer in any category, or function for that matter, in the history of the franchise. Yet, it is the number two most honored production staffer, with 22 wins and nominations, Dan Curry, who holds the record with the most actual wins; nine versus five for Westmore. Westmore has received the following awards and nominations in the various Makeup categories: