"We think it will be a few weeks," coach Doug Marrone said Friday about how long the rookie could be out.

Marrone declined to give a timetable for Manuel's return, saying that further evaluation over the next week was necessary to gauge the progress. NFL Media Insider Ian Rapoport reports that the timetable on Manuel's knee injury is about six weeks. If Manuel heals quickly he could be back in four weeks.

Manuel started the season after missing most of the preseason with an injured left knee and has progressed each start. Any time Manuel misses is a setback, but getting him back for a stretch run is a positive.