Severity of thrombocytopenia does not predict bleeding risk in patients with cirrhosis

A subgroup analysis of a prospective cohort study showed that, although platelet counts worsened with progression of liver disease, platelet counts were similar in patients with and without a bleeding event.

Patent foramen ovale closures are superior to medical therapy in patients with medium to large PFOs

A meta-analysis of four randomized, controlled trials found that patients with cryptogenic stroke who underwent PFO closure had decreased rates of stroke and transient ischemic attack, compared with medical therapy alone, but had increased incidence of atrial fibrillation or atrial flutter.