..To determine the role of Mac-1 during ischemia and reperfusion in the brain, we analyzed the effect of transient focal cerebral ischemia in mice genetically engineered with a specific deficiency in Mac-1...

..In collaboration, our two research laboratories have been defining excitotoxic signals that lead to apoptosis versus necrosis via, among other pathways, Ca2+ signaling mechanisms; this is the subject of this brief review...

..This study reveals not only the molecular mechanism underlying PTX blockade of GABA receptors but also the heteromeric nature of native receptors in the rat retina that underlie the PTX-resistant GABAC response...

MEF2C, a MADS/MEF2-family transcription factor expressed in a laminar distribution in cerebral cortex

..In this review, we present the evidence that clinically safer NMDA antagonists such as memantine and nitroglycerin, and the combination drug nitro-memantine, are promising as drugs in treating neurodegenerative diseases...