Charlie Murphy, the older brother of Eddie Murphy, a “Chappelle’s Show” star and an accomplished comedian in his own right, died Wednesday in New York City. He was 57. Murphy’s publicist confirmed the comedian’s death, and the cause of death was leukemia.

“We just lost one of the funniest most real brothers of all time. Charlie Murphy RIP,” Chris Rock, Murphy’s CB4 co-star, tweeted. “Charlie Murphy changed my life,” tweeted “Chappelle’s Show” co-creator Neal Brennan. “One of the most original people I’ve ever met. Hilarious dude. Habitual Line Stepper. So sad.”

After making his big screen debut in 1989’s “Harlem Nights,” directed by his younger brother Eddie, and appearing in bit roles in Spike Lee films like “Mo’ Better Blues” and “Jungle Fever,” Murphy’s big break came as a cast member on “Chappelle’s Show,” where “Charlie Murphy’s True Hollywood Stories” resulted in a pair of that series’ most memorable sketches.

Both sketches featured Murphy reminiscing about he and Eddie’s celebrity encounters in the Eighties, with Dave Chappelle portraying Rick James and Prince in the now-legendary sketches. Charlie Murphy also co-wrote “Vampire in Brooklyn,” another film directed by Eddie, as well as 2007’s “Norbit.”

Murphy also appeared in 1998’s “The Player’s Club,” directed by Ice Cube. The rapper paid tribute to Murphy on Twitter Wednesday, “Damn, sorry to hear about my friend Charlie Murphy. He took a chance on a young director in The Player’s Club. Always made me laugh. RIP.”

Growing up in the Bushwick area of Brooklyn, Charlie often stuck up for his younger brother; in defending Eddie, Charlie joked about fearing his mom’s wrath if bullies picked on Eddie more than the bullies themselves. That guardian role made Charlie a natural to serve as Eddie’s security guard as the comedian quickly ascended to stardom.

Due to Charlie’s propensity toward overreacting while guarding his brother – “Whoever say something, I almost gave this old man a heart attack on a plane because he asked us if we were a basketball team. I took that personally,” Murphy said in a Chappelle’s Show outtake – forced Murphy to embark on his own career.

One night at an Eddie Murphy stand-up performance, Charlie went after one heckler “who tried to squeeze the lemon.” “I took it as a personal crusade until they were like, ‘You’re a little overzealous in how you’re performing your job.’ So that’s how I ended up not doing [security] anymore,” Murphy said.