Social, life and belongings lost in natural disasters are caused by the disaster itself and the ability of resistance to it. The loss extent caused by the same disaster is obviously different in different social economic environment. Based on data of 1991-2010, relationship between social economic environment and resistance to natural disasters is studied by panel data regression models. Furthermore, the social economic environmental factors which are likely to influence loss extent of natural disasters are analyzed. It is empirically shown that increase of Real GDP per capita, rural per capita net income, population of tertiary industry in GDP and number of doctors per thousand people all can decrease loss extent of natural disasters notably. However, increase of social fixed asset investment and increment speed of GDP cannot influence the loss extent prominently. Increase of disposable income decreases the death toll and the number of people affected by the disasters but enhances direct economic losses. Therefore, the influence of disposable income on the loss is not certain.