Welcome

Many coding genes are well annotated with their biological functions. Non-coding regions typically lack such annotation. GREAT assigns biological meaning to a set of non-coding genomic regions by analyzing the annotations of the nearby genes. Thus, it is particularly useful in studying cis functions of sets of non-coding genomic regions. Cis-regulatory regions can be identified via both experimental methods (e.g. chromatin immunoprecipitation followed by massively parallel sequencing) and by computational methods (e.g. sequence conservation in a given clade).

News

Read about our newly-available GREAT Version 2.0 release which adds genomic region/gene distribution plots and improves the term details page.

GREAT Help

General

Overview - When is GREAT useful, and for which uses should I prefer it to other annotation tools?