The Farrelly brothers—along with the rest of their family members—are in mourning.

Blockbuster comedy director Bobby Farrelly, who along with his brother Peter made Something About Mary, Dumb & Dumber and the upcoming The Three Stooges, has released a statement in the wake of his son Jesse's tragic and sudden death this week.

On Wednesday evening, 20-year-old Jesse Farrelly was deemed unresponsive by paramedics and taken to a nearby hospital where he was pronounced dead. Though autopsy results have not yet been released, the 911 call reportedly referenced a possible overdose, and the family indicated in their just-released statement that the young man had been battling with unspecified substances.

"It is with profound sorrow that we accept the passing of our beloved Jesse following his struggle with addiction," Bobby, wife Nancy and daughters Tiffany and Anna said in a joint statement.

"We fully trust that he is now in the hands of our Lord. We are immeasurably grateful for the abundance of happiness and laughter he brought into our lives, and we will rejoice eternally for all the moments we got to breathe in his wondrous spirit. The family thanks you for your well wishes and kindly asks that you respect our privacy during this difficult time."

A source close to the family told E! News that Jesse had lately been working alongside his father at the Farrelly brothers' production company and was helping out on Stooges, though it's unclear in what capacity.