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FIG. 9.

Model of the lipolytic pathway in β-cells. The model shows that
GLP-1 activates HSL as a consequence of PKA stimulation via cAMP. HSL causes
triglyceride breakdown to FFAs. This is followed by activation of FFAs via ACS
in a triacsin C—inhibitable step with production of the effector signal
LC-CoA. Malonyl CoA prevents the loss of this effector signal (or its products
DAG and PA), by blocking its entry and subsequent oxidation in the
mitochondria. CPT-1, carnitine palmitoyl transferase-1; TG,
triglycerides.