The bombing runs mark the first time Russia has used the territory of another Middle Eastern country for its operations inside Syria

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In this frame grab provided by Russian Defence Ministry press service, Russian long range bomber Tu-22M3 flies during an air strike over Aleppo region of Syria on Tuesday, Aug. 16, 2016. Russia's Defense Ministry said on Tuesday Russian warplanes have taken off from a base in Iran to target Islamic State fighters in Syria.

In a new development in Syria's civil war, Russian bombers took off from a base in Iran to conduct airstrikes in against ISIS in Syria on Tuesday, NBC News reported.

It was the first time Russia used the territory of another Middle Eastern country for its operations inside Syria in support of President Bashar Assad.

Russia's defense ministry said Tu-22M3 and Su-34 bombers took off on raids targeting ISIS and allied Nusra Front militants in Aleppo, Deir el-Zor and Idlib — destroying five major ammunition depots, training camps and three command posts.