locally advanced and metastatic DFSP can be treated with __ due to ___

- imatinib
- imatinib blocks the PDGFB signaling on which the tumor needs for cellular proliferation and survival

t(17;22) COL1A1-PDGFB fusion

Giant cell tumor of tendon sheath and pigmented villonodular synovitis have been shown to be true neoplasms based on ___

- finding recurrent t(1;2) CSF1-COL6A3 fusion in a significant number of GCTTS and PVNS

- leads to overexpression of CSF1, which is detected in the minority of intratumoral cells (only a minority of cells in GCTSS and PVNS are neoplastic - the others are recruited by the local overexpression of CSF1)