President Barack Obama and Mexican President Felipe Calderon will tackle a sweeping array of issues, from Mexico’s bloody drug war to Arizona’s controversial new immigration law, when they meet at the White House on Wednesday.

Calderon’s two-day visit — his fourth bilateral meeting with Obama — will include a joint press conference in the Rose Garden and a state dinner honoring him and his wife Margarita Zavala.

“There is no more important relationship for the United States than our relationship with our neighbor,” a senior administration official told reporters.

Security is a “big component of the bilateral relationship,” the official said. And the two presidents will discuss law enforcement, dismantling drug operations and creating a “modern and efficient” border.

Already, the Merida Initiative has provided $1.3 billion in U.S. assistance to help Mexico fight drug cartels.

On immigration, both Obama and Calderon have condemned the new Arizona law.

“The president will reiterate his commitment to fixing our broken immigration system,” and express his personal “frustration” to Calderon, the official said.

Arizona’s crackdown on illegal immigrants has “resonated in Mexico and is of great importance to the Mexican government,” the official said, adding that the White House expects “Calderon to discuss his views as he has been doing in public.”

In fact, the Mexican president has been quite vocal. “We are bringing our protest to the United States government during my state visit and in front of the U.S. Congress,” he told Reuters in an interview last week.

The two presidents will also talk about economic competitiveness, including their shared goal of creating clean energy economies, the official said. They will also discuss the upcoming G-20 summit in Toronto, as well as the next United Nations climate change conference in Cancun, Mexico.

And they’re expected to address a longstanding dispute over allowing Mexican trucks on U.S. highways.