rechallenge

Definition of rechallenge

(Entry 1 of 2)

medical

: a physiological or immunological challenge (see challengeentry 2 sense 4) made subsequent to a previous challenge: such as

a: the readministration of a drug or other substance suspected of causing a prior adverse reaction in order to determine a definitive link by observing the patient's reaction
the necessity of rechallenge when no suitable alternative exists

b: the readministration of an antineoplastic agent to a previously treated patient
rechallenge with cisplatin in relapsing ovarian cancer patients

c: the subsequent transfer of a disease-causing agent (such as a virus or tumor cell) into a living organism and especially an experimental animal following immunotherapy for the purpose of determining robustness of the immunological response
mice rechallenged with respiratory syncytial virustumor rechallenge

: to challenge again
But now a new breed of independent store is beginning to rechallenge the chains and discount online retailers.— Madhusmita BoraTo his great joy he reappeared at the same hour, toward the going down of the sun, and rechallenged Wunzh to a trial of strength.— Helen A. Clarkespecificallyto readminister a physiological and especially an immunological challenge (see challengeentry 2 sense 4) to (an organism or cell) When a drug is suspected of causing an adverse but not life-threatening condition, the simplest way to get an answer is to rechallenge the patient with the drug under controlled conditions. — Abigail Zuger