Apokyn

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Apokyn

OVERDOSE

A 62-year-old man accidentally injected 25 mg of APOKYN
subcutaneously. After 3 minutes, the patient felt nauseated and lost
consciousness for 20 minutes. Afterwards, he was alert with a heart rate
40/minute and a supine
blood pressure of 90/50. He recovered completely within an hour.

CONTRAINDICATIONS

APOKYN is contraindicated in patients:

Using concomitant drugs of the 5HT3 antagonist class
including antiemetics (e.g., ondansetron, granisetron, dolasetron,
palonosetron) and alosetron [see DRUG INTERACTIONS]. There have been
reports of profound hypotension and loss of consciousness when APOKYN was
administered with ondansetron.

With hypersensitivity/allergic reaction characterized by
urticaria, rash, pruritus, and/or various manifestations of angioedema to
apomorphine or to any of the excipients including a sulfite (i.e., sodium
metabisulfite). Patients with a sulfite sensitivity may experience various
allergic-type reactions, including anaphylactic symptoms and life-threatening
asthmatic attacks. Patients who experience any hypersensitivity/allergic
reaction to APOKYN should avoid taking APOKYN again.

Last reviewed on RxList: 8/8/2014
This monograph has been modified to include the generic and brand name in many instances.