STNews

The BLAST software used in CAS REGISTRY BLAST was upgraded to version 2.2.29. CAS REGISTRY BLAST is the integrated software and data solution created by CAS for sequence searching in STN Express® and STN® on the WebSM. The backbone to CAS REGISTRY BLAST is BLAST software, developed by the U.S. National Center for Biotechnology Information (NCBI).

Key changes in this version are as follows:

Expanded search capabilities: It is now possible to search proteins that include J (leucine or isoleucine) and/or O (pyrrolysine) residues.

Better results ranking: Sequences with gaps are now scored differently. Instead of a score for each individual sequence separated by a gap, a score is computed for the entire sequence including the gap. This often results in gapped sequences appearing lower in the BLAST report than they would have before.

CAS REGISTRY BLAST continues to provide unique value to searchers by covering sequences from patents as well as journals, and by providing access to records in CAplusSM where the sequences were reported.

STN Express and STN on the Web Releases Enhance Precision of Structure Searching Results and Efficiency

Effective May 27, 2014:

A maintenance release of STN Express, Version 8.5.2.1, is available on the STN® License and Download Software site

A new Structure Plug-in is available within STN on the Web

These new releases provide enhanced precision of structure searches involving G-groups, and increase structure search efficiency. We recommend that structure searchers (especially those using STN Express 8.5.2) immediately take advantage of the new releases.

The Embase, Embase Alert, MEDLINE and SciSearch databases each include organizational affiliation (corporate source) data for all authors, as available.

For multi-authored works referenced in these databases, the order in which author names appeared in the original source document is not always evident.

Effective June 29, 2014, the AUPB (Authors in Publication Order) field will provide AUPB data for search and custom display. It has been added to the ALL and IALL formats in each of these databases.

Additional Experimental Spectra Now Available in CAS REGISTRY on STN

Effective May 2014, CAS enhanced its collection of experimental spectra available in CAS REGISTRY. In addition to the 1.3 million experimental spectra already available, CAS added more than 17,000 NMR spectra to CAS REGISTRY. The specific atoms covered are carbon, hydrogen, fluorine, nitrogen and phosphorus. The breakdown is as follows:

CAplus has long been a major source of cited reference information. Cited references in CAplus originate from the bibliography at the end of a journal article, as well as from patents, which reference other patents as well as non-patent literature. CAplus recently reached a major milestone when it added its 400 millionth cited reference! Thousands of new cited references are added to CAplus every week. Click here to find more information on CAS coverage of cited references.

Looking at the most frequently cited publications (or articles), we find that many of them discuss what are now standard laboratory protocols and procedures, and tools for scientific data analysis. Their topics include: protein measurement and identification, RNA isolation, and sequence searching. Here are the top ten most cited references, as of June 2014:

Here are two ways unlimited STN access can add value for your organization:

Try new STN! Available exclusively to fixed fee and Global Value Pricing customers, new STN leverages cutting-edge technology to deliver an intuitive, powerful interface designed for professionals. New STN revolutionizes patent searching by making it possible to quickly and efficiently explore the unique content STN offers to find answers and develop unique insights not possible before. New STN benefits new and experienced STN searchers with:

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Stay up-to-date with STN current awareness alerts. Alerts automatically deliver customized updates that provide stakeholders with the most current perspective, giving your organization a decisive information advantage in areas such as competitive intelligence, strategic planning and IP portfolio management. Be the first to know about newly disclosed substances, the latest research breakthroughs and changes in the patent landscape. Unlimited alerts are included for all Global Value Pricing customers. Learn more about STN alerts here.

This month's article is titled "Use of Multiple Repeating Groups in New STN Allows for Precise Broadening of Structure Queries."

The enhanced search power of new STN provides opportunities for greater structure search precision, even for broad queries, allowing you to fully represent the specific requirements of each search project. For example, the enhanced search capacity of new STN supports structure queries that include multiple repeating groups. This allows you more flexibility to add controlled variability to find similar substances to a substance of interest. The broad results set can then be narrowed for a specific use or application. Read more here.

Faced with a challenging search or require comprehensive results? Contact the expert research staff at Science IP.

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