establish a registry of DNA [ Time Frame: 4 years ] [ Designated as safety issue: No ]

For the purpose of facilitating future genetic laboratory investigations of late effects among of survivors of cancer, tumors, or a related illness. Patients in the ALTFU Program are followed for secondary malignant neoplasms and other adverse outcomes (so-called "late effects") including cardiomyopathy, pulmonary fibrosis, cardiac valvular pathology, osteoporosis, and others. The following data will be ascertained from each study participant: (1) family history information will be ascertained using the Family History Questionnaire (Appendix A); and (2) saliva or blood samples for genetic analysis.

Biospecimen Retention: Samples With DNA

Saliva or blood samples will be collected in the clinic at the time of a routine visit.

The purpose of this study is to establish a registry of survivors of cancer, tumors,or a related illness. The registry will include detailed family history and germline DNA. Ultimately, we hope to improve our understanding of genetic susceptibility to secondary malignant neoplasms and other late effects among survivors of cancer, tumors, or a related illness.

Genetic: Family History Questionnaire (FHQ) and Saliva or blood samples

Consented subjects will be given the Family History Questionnaire (FHQ) (Appendix A), to complete either in clinic or at home. For participants who are children and can not fill out the questionnaire on their own, the clinic RSA will instruct the parent or guardian present to fill out the questionnaire, reminding them that the "You" in the questionnaire refers to their child. Saliva or blood samples will be collected in the clinic at the time of a routine visit. The patient will decide which type of sample they would like to donate. For children who are ten years of age or younger, who cannot be expected to produce a saliva sample, approximately 3-5cc of blood will be collected.

Eligibility

Genders Eligible for Study:

Both

Accepts Healthy Volunteers:

No

Sampling Method:

Non-Probability Sample

Study Population

Patients from the Adult Long-Term Follow-Up Program, the Pediatric Long Term Follow-up Program, or Lymphoma Service will be recruited at a routine visit to MSKCC.

Criteria

Inclusion Criteria:

English speaking

A personal history of cancer tumor, or a related illness

Followed in the the Adult Long Term Follow Up Program, Pediatric Long Term Follow Up Program, or Lymphoma Service at MSKCC

Exclusion Criteria:

Evidence of active progression of disease or recurrence

Neurocognitive deficits that impair ability to give informed consent.

Contacts and Locations

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study.
To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below.
For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01667952