Protein Biomarkers of Cancer Risk in Older Persons

Using a case-cohort study design, this study evaluates if baseline plasma proteomic patterns can be used to distinguish between subjects who will and will not develop breast, colorectal, lung, and prostate cancers. In addition, it evaluates if the addition of known risk factors for these cancers to our proteomic algorithms and/or changes in proteomic patterns over time will enhance the predictive power of this approach as a screening test for cancer.