FK Teplice was founded in 1945, in the aftermath of the Second World War. Nicknamed The Glassmakers, the team have competed in the top divisons of both Czechoslovakia and the Czech Republic's respective football league systems. The club have enjoyed success at domestic level and have represented their country in both the UEFA Cup and the UEFA Champions League.

In the years after their foundation, Teplice made a solid start and within three years, they had gained promotion to the Czechoslovak First League, the country's top flight. In the decades that followed, the team bounced between the first and second divisons, without winning any major honours. In 1975, they won the Iran International Tournament, a friendly competition containing various international teams. After the Czech Republic gained independence, Teplice were placed into the second tier. A second place finish in the 1995-96 season earned Teplice promotion to the Gambrinus Liga, where they have remained ever since.

Upon entering the top division, the club quickly established itself and began to challenge for major honours. In their third season in the division, Teplice finished as runners up to Sparta Praha. As a result of this league finish, they qualified for the following season's Champions League. In 2002-03, the team beat Jablonec in the final to lift the Czech Cup for the first time and claim their first major trophy as a club. They lifted the cup for a second time in 2008-09, after beating Slovácko.

Bosnian striker Edin Džeko is perhaps the club's best-known former talent and he played for the club between 2005 and 2007. Other notable former players include Czech internationals like Pavel Verbíř, Josef Masopust, Martin Fenin and Tomáš Jun.

Teplice play their home matches at Na Stínadlech, which first opened its doors in 1973. The stadium is often used for international qualifiers by the Czech Republic national team and is able to hold up to 18,221 supporters.