Hantavirus nucleocapsid protein: a multifunctional molecule with both housekeeping and ambassadorial duties

Hantavirus nucleocapsid protein: a multifunctional molecule with both housekeeping and...
Kaukinen, P.; Vaheri, A.; Plyusnin, A.
2005-09-01 00:00:00
In recent years important progress has been made studying the nucleocapsid (N) protein of hantaviruses. The N protein presents a good example of a multifunctional viral macromolecule. It is a major structural component of a virion that encapsidates viral RNA (vRNA). It also interacts with the virus polymerase (L protein) and one of the glycoproteins. On top of these “house keeping” duties, the N protein performs interactive “ambassadorial” functions interfering with important regulatory pathways in the infected cells.
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Hantavirus nucleocapsid protein: a multifunctional molecule with both housekeeping and ambassadorial duties

Abstract

In recent years important progress has been made studying the nucleocapsid (N) protein of hantaviruses. The N protein presents a good example of a multifunctional viral macromolecule. It is a major structural component of a virion that encapsidates viral RNA (vRNA). It also interacts with the virus polymerase (L protein) and one of the glycoproteins. On top of these “house keeping” duties, the N protein performs interactive “ambassadorial” functions interfering with important regulatory pathways in the infected cells.