WJPR Citation

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar. Best Paper Award : Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

ANTIOXIDANT AND ANTI-INFLAMMATORY POTENTIAL OF THE AQUEOUS EXTRACT OF THE PEEL OF A SRI LANKAN VARIETY OF NEPHELIUM LAPPACEUM LINN.

Plant-based remedies play a significant role in healthcare due to low
side effects compared to that of synthetic drugs. Excess free radicals
generated in the human body are implicated in numerous diseases as
well as in aging. This study involves the determination of antioxidant
and anti-inflammatory activities of the aqueous extract of the peel of a
Sri Lankan variety of rambutan (AEPR); Malwana special. The AEPR
was prepared according to “kasaya” preparation method in Ayurvedic
medicine. The total phenolic content and the total flavonoid content of
AEPR were 463.5±5.2 mg (PGE)/g and 375.0±13.2 mg (QE)/g
respectively. (PGE=Pyrogallol Equivalence, QE=Quercetin
Equivalence). The 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical
scavenging activity of AEPR was 3.9-64.5% for concentrations of 10–500 μg/ml. Ascorbic
acid gave values of 6.5-96.4%. The hydroxyl radical scavenging activity of AEPR ranged
from 10.3-35.0% for concentrations of 1000–1500 ppm. Ascorbic acid showed values of
22.6-51.1%. The extract exhibited a good reducing power in the iron reducing power assay.
Nitric oxide radical scavenging activity of AEPR was 4.1-31.7% for concentrations of 100–
500 μg/ml. Ascorbic acid gave values of 30.1-43.3%. The protection reported for Human Red
Blood Cell (HRBC) assay was 17.1-34.8% for concentrations from 35.5-250.0 ppm. Aspirin
protection ranged from 32.3-54.5%. These results show that the AEPR prepared from peel waste has a potential to be used as an antioxidant and also it possesses anti-inflammatory activity.