Based on the hit movie of the same name, Uncle Buck (Mike Epps) is a charismatic hustler who has gotten by on his charm for years. But when his brother, Will (James Lesure), and sister-in-law, Alexis (Nia Long), move to town and need help with their kids, he steps up to become their "manny," and their lives will never be the same. Will and Alexis are wary of Buck's questionable parenting skills, but his unique perspective and street smarts provide some unconventional solutions to raising their three rambunctious kids, who typically make a hobby out of terrorizing their nannies.