ed AstraZeneca (NYSE: A class small HREF http://studio-5.financi...Rosuvastatin is not indicated for the prevention of cardiovasculareve...Rosuvastatin 20 mg was well tolerated in nearly 9000 patients during...ABOUT JUPITER: ...JUPITER (Justification for the Use of statins in Primary prevention: a...

ed, AstraZeneca (NYSE: AZN) expects to file a
regulatory submission including the JUPITER data in the first half of 2009
and if approved, will begin promotional activities within the approved
labeling.

Rosuvastatin is not indicated for the prevention of cardiovascular
events. Rosuvastatin should be used according to the prescribing
information, which contains recommendations for initiating and titrating
therapy according to the individual patient profile. In most countries, the
usual recommended starting dose of rosuvastatin is 10 mg.

Rosuvastatin 20 mg was well tolerated in nearly 9,000 patients during
the course of the study. There was no difference between treatment groups
for major adverse events, including cancer or myopathy. There was a small
increase in physician reported diabetes consistent with data from other
large placebo controlled statin trials.

ABOUT JUPITER:

JUPITER (Justification for the Use of statins in Primary prevention: an
Intervention Trial Evaluating Rosuvastatin) was a long-term, randomized,
double-blind, placebo-controlled, large-scale study of 17,802 patients
designed to determine if rosuvastatin 20 mg decreases the risk of heart
attack, stroke and other major cardiovascular events in patients with low
to normal LDL-C but at increased cardiovascular risk as identified by
elevated high-sensitivity C-reactive protein (hsCRP) and age. The majority
of patients had at least one other risk factor including hypertension, low
HDL-C, family history of premature coronary heart disease (CHD) or smoking.
hsCRP is a recognized marker of inflammation which is associated with an
increased risk of atherosclerotic cardiovascular events.

JUPITER is a part of AstraZeneca's extensive GALAXY clinical trials'/>"/>

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