MOSCOW, Russia (CNN) - The United States is "absolutely not" giving Israel a green light to attack Iran, U.S. President Barack Obama told CNN Tuesday.

"We have said directly to the Israelis that it is important to try and resolve this in an international setting in a way that does not create major conflict in the Middle East," Obama said, referring to Iran's nuclear ambitions.

U.S. Vice President Joe Biden appeared to leave the door open on Sunday for Israel to attack Iran if it saw fit.

"Israel can determine for itself - it's a sovereign nation - what's in their interest and what they decide to do relative to Iran and anyone else," Biden said on ABC's "This Week."