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Sant' Angelo was born a nobleman in Florence, Italy, as the son of a Florentine count. He received a degree in architecture at the University of Florence, then later studied industrial design & ceramics. He also studied with Picasso for six months, as the result of winning an international ceramics competition, sponsored by the French government. Picasso encouraged his student to "trust his own restless creativity and to keep on trying new artistic ventures," and Sant'Angelo created an animated film cartoon and submitted it to Walt Disney. Impressed by the film's inventiveness, Disney brought him to Hollywood and gave him an apprenticeship. But unable to speak English well, Sant'Angelo was lost in the vastness of Los Angeles and quit after 15 days.[1]

Sant'Angelo opened his own ready-to-wear business in 1966. He experimented with knits, and developed new fabrications with textile mills like DuPont. He also collaborated with textile converters like Crantex, to create his own prints, and leather makers like Calderon, for his accessories. He cited various native & ethnic cultures as the inspiration for his collections, like the American Indian or the Bohemian Gypsy. But his most important contribution to modern women's clothing at the time was his liberating construction techniques and his use of stretch fabrics. He rejected the traditional shift with the zipper-up-the-back, and instead, designed clothing that wrapped, tied, hung or clung to the body. He didn't simply design clothes, he ornamented the body and made fantasy wearable. He made couture pieces for celebrities & entertainers as well. Eventually, he started to license his name and expand into cheaper, more affordable clothing. The first line was called Sant'Angelo 4U2, which were less expensive versions of his fantasy pieces. Then there was the 'Marjer Parts' line, which was also more affordable, but more trend-influenced. Later, he dropped the 'di' from his last name & licensed out his name as Giorgio Sant'Angelo. Unfortunately, much of that clothing did not have his own hand involved, and instead, was overly commercial and did not possess his innovative signature.

In the mid-1980s, Sant'Angelo added the 'di' back to his last name & continued to design his high end signature line. Made almost entirely out of stretch knits, critics hailed it, confirming the return of his influence. The versatile, wrap stretch pieces of clothing, in unique materials, colors & patterns, proved an antidote to the overly tailored styles of the time. Unfortunately, Sant'Angelo died in 1989, so his comeback was short-lived. But his legend continues in the minds of modern-day fashionistas, with designers like John Galliano & Marc Jacobs citing him as an influence. He was given a plaque on the '7th Avenue walk of fame' along with his contemporaries like Halston and Stephen Burrows.