With a BMI of 34, Nancy is obese. She's 40 years old and
5 feet 4 inches tall and weighs 200 lbs. Nancy has type 2 diabetes and has been
taking medicine for this condition for the past 2 years. She's hoping that by losing weight with
XENICAL and eating a reduced-calorie diet she will be able to manage her
diabetes better and lower her risk of coronary heart disease.

Like so many of us, Nancy is concerned that she'll lose weight only to gain
it back later. Fortunately, according to clinical studies, XENICAL plus diet can help
people lose weight and keep it off.

Here's something else that can help Nancy remain committed to her
weight-loss plan: weight loss with XENICAL plus diet can help people
control their high blood sugar levels. Patients who are considerably overweight and have type 2 diabetes, are at increased risk for coronary heart
disease.

Results with XENICAL

Weight loss with XENICAL plus diet may improve blood sugar control and may reduce risk factors such as high lipid levels and high blood pressure.

The long-term benefits of XENICAL on
weight-related illnesses and life expectancy have not been studied.

*These patients are not real individuals. They are representative patient
profiles based on data from clinical studies.

Lowered absorption of certain vitamins in your body. Take a multivitamin containing vitamins A, D, E, K, and beta-carotene one time each day. Take a multivitamin at least 2 hours before or after you take XENICAL, such as at bedtime.

Severe liver problems. Stop taking XENICAL and call your doctor right away if you have the following symptoms of liver problems:

loss of appetite

itchy skin

yellowing of your skin or the white part of your eyes

amber-colored urine

light-colored bowel movements (stools)

pain in the upper right portion of your stomach

Kidney problems. Your doctor may do certain tests to check your kidney function during treatment with XENICAL. Call your doctor right away if you have the following symptoms of kidney problems:

swelling, especially of the legs and feet

little or no urine output

frequent or painful urination

blood in the urine

loss of appetite, nausea and vomiting

severe pain in the back, belly or groin

Gallbladder problems (gallstones). Call your doctor right away if you have the following symptoms of gallstones:

pain in the upper right portion of your stomach

nausea

vomiting

The most common side effects of XENICAL include:

oily* rectal discharge

passing gas with oily discharge*

urgent need to have a bowel movement

oily* or fatty stools

increased number of bowel movements

being unable to control your bowel movements

*Oily discharge may be clear or have an orange or brown color.

How should I take XENICAL?

Take XENICAL exactly as your doctor tells you to take it.

Your doctor will tell you how much XENICAL to take and when to take it.

Take XENICAL with your meals or up to one hour after your meal. If you miss a meal or have a meal without fat, you can skip your dose of XENICAL. If you take a cyclosporine medicine, take XENICAL and cyclosporine at least 3 hours apart. See "What should I tell my doctor before taking XENICAL?" for a complete list of cyclosporine medicines.

If you take a multivitamin, take it at least 2 hours before or after you take XENICAL. Bedtime is a good time to take your multivitamin.

Take XENICAL with a nutritionally balanced, low calorie diet that has no more than about 30% of calories from fat. Taking XENICAL with any meal high in fat (more than 30% fat) may make the common side effects worse.

If you take too much XENICAL call your doctor or go to the nearest hospital
emergency room right away.

These are not all the possible side effects of XENICAL. For more information, ask your doctor or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.