As we know, the MPXx6250A is an absolute pressure sensor. The absolute pressure is the difference between the pressure at a given point and the absolute zero of pressure or a perfect vacuum. In other words: pressure is applied on Port P1 of the sensor while the Port P2 of the sensor is a vacuum sealed reference.

The pressure range of the MPXx6250A is from 20 kPa to 250 kPa (5.906 inHg - 73.825 inHg), which is within the levels mentioned.