Watch a neuroscientist explain one concept at 5 levels of difficulty

Explaining a scientific concept in a clear, understandable way is hard enough–we do it with varying degrees of success here every week–but Wired recently challenged neuroscientist Bobby Kasthuri to take it to the next level. They asked him to explain the connectome–a kind of map of all the neural connections in the brain–to five people with different levels of scientific knowledge, starting with a 5-year-old all the way up to a fellow neuroscientist.

Watch as Kasthuri, who is a neuroscience researcher at Argonne National Laboratory and part-time assistant professor of neurobiology at UChicago, puts on a master class in explaining a difficult concept to anyone.