Resveratrol protects against Stress

Resveratrol Gains A New Talent

A research group from The Scripps Research Institute (TSRI), discovered a novel target for resveratrol as published this month of December (Nature, doi:10.1038). The Nature article is very interesting among other things because it demonstrates further how versatile resveratrol really is.

Resveratrol Really Does It All

As the article reviews in its abstract about resveratrol, “resveratrol…provides cardio-neuro-protective, anti-diabetic and anti-cancer effects”. For a compound to have such large repertoire of functions, it becomes apparent that it must have multiple cellular targets in order to be able to respond in such versatile manner.

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Resveratrol Involed In Stress Response

Case in point, researchers in 2012 discovered that resveratrol directly binds and blocks the activity of enzymes called phosphodiesterase (PDE) and this was believed to mediate key stress response proteins that lead to the prevention of the age-associated metabolic diseases (for a review of that article, please read our February 2012 Resveratrol Newsletter).

More Stress Protection From Resveratrol

In this newly published article, the TSRI research group discovered that resveratrol directly bound to an enzyme called tRNA synthetase, which are normally involved in making proteins. The novel aspect of this observation is that when resveratrol bound to tRNA synthetases, it redirected the enzymes to activate stress protein pathways, which is an entirely new function for this enzyme. However, this article is similar to prior resveratrol research, in that resveratrol again is involved in activation of stress responses that may lead to protection of cells and tissues and prevent the age-associated diseases that may lead to extension of lifespan. In addition to discovering a new cellular target for resveratrol, the researchers also noted that this target was 1,000 times more sensitive than other resveratrol targets. This too was novel and may help explain what has been apparent for many researchers, that resveratrol affects diverse cells differently and at different concentrations. It may be that resveratrol stress activation pathway involving tRNA synthetase may be more important for some cells than in others. With this in mind, it will now be interesting to determine how to maximize the benefits of resveratrol in a cell/tissue specific manner that delay the onset of age-related diseases. Until then, regardless of the target, stress pathway activation or sensitivity, please continue to take resveratrol to obtain the health benefits.

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