Population Architecture using Genomics and Epidemiology (PAGE)

This program is designed to study the “epidemiological architecture” of established GWAS findings in diverse and well characterized cohorts. The focus of this research is to investigate if genetic variants initially identified through GWAS research are a) generalizing across ancestral groups, b) modified by environmental factors (gene-environment interactions) and c) associated with various outcomes (pleiotropy). PAGE is studying a variety of outcomes, including cardiovascular diseases, stroke, obesity, diabetes, insulin glucose, inflammation, lipids, cancer reproductive history, ECG phenotypes among others. PAGE is conducting candidate SNP genotyping of GWAS findings as well as comprehensive fine-mapping of GWAS regions to aid the identification of underlying functional variants. Drs. Kooperberg and Peters co-lead the Women’s Health Initiative efforts of PAGE.