PATIENT INFORMATION

Read this Medication Guide carefully before you start
taking WELLBUTRIN and each time you get a refill. There may be new information.
This information does not take the place of talking with your healthcare
provider about your medical condition or your treatment. If you have any
questions about WELLBUTRIN, ask your healthcare provider or pharmacist.

IMPORTANT: Be sure to read the three sections of this Medication
Guide. The first section is about the risk of suicidal thoughts and actions
with antidepressant medicines; the second section is about the risk of changes
in thinking and behavior, depression and suicidal thoughts or actions with
medicines used to quit smoking; and the third section is entitled “What Other
Important Information Should I Know About WELLBUTRIN?”

Antidepressant Medicines, Depression and Other Serious
Mental Illnesses, and Suicidal Thoughts or Actions

This section of the Medication Guide is only about the
risk of suicidal thoughts and actions with antidepressant medicines. Talk to
your healthcare provider or your family member's healthcare provider about:

all risks and benefits of treatment with antidepressant
medicines

all treatment choices for depression or other serious
mental illness

What is the most important information I should know
about antidepressant medicines, depression and other serious mental illnesses,
and suicidal thoughts or actions?

1. Antidepressant medicines may increase suicidal
thoughts or actions in some children, teenagers, or young adults within the
first few months of treatment.

2. Depression or other serious mental illnesses are
the most important causes of suicidal thoughts and actions. Some people may
have a particularly high risk of having suicidal thoughts or actions. These
include people who have (or have a family history of) bipolar illness (also
called manic-depressive illness) or suicidal thoughts or actions.

3. How can I watch for and try to prevent suicidal
thoughts and actions in myself or a family member?

Pay close attention to any changes, especially sudden
changes, in mood, behaviors, thoughts, or feelings. This is very important when
an antidepressant medicine is started or when the dose is changed.

Call your healthcare provider right away to report new or
sudden changes in mood, behavior, thoughts, or feelings.

Keep all follow-up visits with your healthcare provider
as scheduled. Call the healthcare provider between visits as needed, especially
if you have concerns about symptoms.

Call your healthcare provider right away if you or
your family member has any of the following symptoms, especially if they are
new, worse, or worry you:

Never stop an antidepressant medicine without first
talking to a healthcare provider. Stopping an antidepressant medicine
suddenly can cause other symptoms.

Antidepressants are medicines used to treat depression
and other illnesses. It is important to discuss all the risks of treating
depression and also the risks of not treating it. Patients and their families
or other caregivers should discuss all treatment choices with the healthcare
provider, not just the use of antidepressants.

Antidepressant medicines have other side effects. Talk
to the healthcare provider about the side effects of the medicine prescribed
for you or your family member.

Antidepressant medicines can interact with other
medicines. Know all of the medicines that you or your family member takes.
Keep a list of all medicines to show the healthcare provider. Do not start new
medicines without first checking with your healthcare provider.

It is not known if WELLBUTRIN is safe and effective in
children under the age of 18.

This section of the Medication Guide is only about the
risk of changes in thinking and behavior, depression and suicidal thoughts or
actions with drugs used to quit smoking.

Although WELLBUTRIN is not a treatment for quitting
smoking, it contains the same active ingredient (bupropion hydrochloride) as
ZYBAN® which is used to help patients quit smoking.

Some people have had changes in behavior, hostility,
agitation, depression, suicidal thoughts or actions while taking bupropion to
help them quit smoking. These symptoms can develop during treatment with
bupropion or after stopping treatment with bupropion.

If you, your family member, or your caregiver notice
agitation, hostility, depression, or changes in thinking or behavior that are
not typical for you, or you have any of the following symptoms, stop taking
bupropion and call your healthcare provider right away:

thoughts about suicide or dying

attempts to commit suicide

new or worse depression

new or worse anxiety

panic attacks

feeling very agitated or restless

acting aggressive, being angry, or violent

acting on dangerous impulses

an extreme increase in activity and talking (mania)

abnormal thoughts or sensations

seeing or hearing things that are not there
(hallucinations)

feeling people are against you (paranoia)

feeling confused

other unusual changes in behavior or mood

When you try to quit smoking, with or without bupropion,
you may have symptoms that may be due to nicotine withdrawal, including urge to
smoke, depressed mood, trouble sleeping, irritability, frustration, anger,
feeling anxious, difficulty concentrating, restlessness, decreased heart rate,
and increased appetite or weight gain. Some people have even experienced
suicidal thoughts when trying to quit smoking without medication. Sometimes
quitting smoking can lead to worsening of mental health problems that you
already have, such as depression.

Before taking bupropion, tell your healthcare provider if
you have ever had depression or other mental illnesses. You should also tell
your healthcare provider about any symptoms you had during other times you
tried to quit smoking, with or without bupropion.

What Other Important Information Should I Know About
WELLBUTRIN?

Seizures: There is a chance of having a seizure
(convulsion, fit) with WELLBUTRIN, especially in people:

with certain medical problems.

who take certain medicines.

The chance of having seizures increases with higher doses
of WELLBUTRIN. For more information, see the sections “Who should not take
WELLBUTRIN?” and “What should I tell my healthcare provider before taking
WELLBUTRIN?” Tell your healthcare provider about all of your medical conditions
and all the medicines you take. Do not take any other medicines while you
are taking WELLBUTRIN unless your healthcare provider has said it is okay to
take them.

If you have a seizure while taking WELLBUTRIN, stop
taking the tablets and call your healthcare provider right away. Do not
take WELLBUTRIN again if you have a seizure.

High blood pressure (hypertension). Some people get
high blood pressure that can be severe, while taking WELLBUTRIN. The chance
of high blood pressure may be higher if you also use nicotine replacement
therapy (such as a nicotine patch) to help you stop smoking.

Manic episodes. Some people may have periods of
mania while taking WELLBUTRIN, including:

Greatly increased energy

Severe trouble sleeping

Racing thoughts

Reckless behavior

Unusually grand ideas

Excessive happiness or irritability

Talking more or faster than usual

If you have any of the above symptoms of mania, call your
healthcare provider.

Unusual thoughts or behaviors. Some patients have
unusual thoughts or behaviors while taking WELLBUTRIN, including delusions
(believe you are someone else), hallucinations (seeing or hearing things that
are not there), paranoia (feeling that people are against you), or feeling
confused. If this happens to you, call your healthcare provider.

Severe allergic reactions. Some people can have severe
allergic reactions to WELLBUTRIN. Stop taking WELLBUTRIN and call your
healthcare provider right away if you get a rash, itching, hives, fever,
swollen lymph glands, painful sores in the mouth or around the eyes, swelling
of the lips or tongue, chest pain, or have trouble breathing. These could be
signs of a serious allergic reaction.

What is WELLBUTRIN?

WELLBUTRIN is a prescription medicine used to treat
adults with a certain type of depression called major depressive disorder.

are taking any other medicines that contain bupropion,
including ZYBAN (used to help people stop smoking) APLENZIN®,
FORFIVO XL™ , WELLBUTRIN SR®, or WELLBUTRIN XL®. Bupropion is the same active ingredient that is in WELLBUTRIN.

drink a lot of alcohol and abruptly stop drinking, or use
medicines called sedatives (these make you sleepy), benzodiazepines, or
anti-seizure medicines, and you stop using them all of a sudden.

are a diabetic taking insulin or other medicines to
control your blood sugar.

drink alcohol.

abuse prescription medicines or street drugs.

are pregnant or plan to become pregnant.

are breastfeeding. WELLBUTRIN passes into your milk in
small amounts.

Tell your healthcare provider about all the medicines
you take, includingprescription, over-the-counter medicines,
vitamins, and herbal supplements. Many medicines increase your chances of
having seizures or other serious side effects if you take them while you are
taking WELLBUTRIN.

How should I take WELLBUTRIN?

Take WELLBUTRIN exactly as prescribed by your healthcare
provider.

Take WELLBUTRIN at the same time each day.

Take your doses of WELLBUTRIN at least 6 hours apart.

Do not chew, cut, or crush WELLBUTRIN tablets.

You may take WELLBUTRIN with or without food.

If you miss a dose, do not take an extra dose to make up
for the dose you missed. Wait and take your next dose at the regular time. This
is very important. Too much WELLBUTRIN can increase your chance of having a
seizure.

If you take too much WELLBUTRIN, or overdose, call your
local emergency room or poison control center right away.

Do not take any other medicines while taking
WELLBUTRIN unless your healthcare provider has told you it is okay.

If you are taking WELLBUTRIN for the treatment of major
depressive disorder, it may take several weeks for you to feel that WELLBUTRIN
is working. Once you feel better, it is important to keep taking WELLBUTRIN
exactly as directed by your healthcare provider. Call your healthcare provider
if you do not feel WELLBUTRIN is working for you.

Do not change your dose or stop taking WELLBUTRIN without
talking with your healthcare provider first.

What should I avoid while taking WELLBUTRIN?

Limit or avoid using alcohol during treatment with
WELLBUTRIN. If you usually drink a lot of alcohol, talk with your healthcare
provider before suddenly stopping. If you suddenly stop drinking alcohol, you
may increase your risk of having seizures.

Do not drive a car or use heavy machinery until you know
how WELLBUTRIN affects you. WELLBUTRIN can affect your ability to do these
things safely.

What are possible side effects of WELLBUTRIN?

See “What Other Important Information Should I Know
About WELLBUTRIN?”

If you have nausea, take your medicine with food. If you
have trouble sleeping, do not take your medicine too close to bedtime.

Tell your healthcare provider right away about any side
effects that bother you.

These are not all the possible side effects of
WELLBUTRIN. For more information, ask your healthcare provider or pharmacist.

Call your healthcare provider for medical advice about
side effects. You may report side effects to FDA at 1-800-FDA-1088.

You may also report side effects to GlaxoSmithKline at
1-888-825-5249.

How should I store WELLBUTRIN?

Store WELLBUTRIN at room temperature between 59°F and
86°F (15°C to 30°C).

Keep WELLBUTRIN Tablets dry and out of the light.

Keep WELLBUTRIN and all medicines out of the reach of
children.

General Information about WELLBUTRIN.

Medicines are sometimes prescribed for purposes other
than those listed in a Medication Guide. Do not use WELLBUTRIN for a condition
for which it was not prescribed. Do not give WELLBUTRIN to other people, even
if they have the same symptoms you have. It may harm them.

If you take a urine drug screening test, WELLBUTRIN may
make the test result positive for amphetamines. If you tell the person giving
you the drug screening test that you are taking WELLBUTRIN, they can do a more
specific drug screening test that should not have this problem.

This Medication Guide summarizes important information
about WELLBUTRIN. If you would like more information, talk with your healthcare
provider. You can ask your healthcare provider or pharmacist for information
about WELLBUTRIN that is written for healthcare professionals.

For more information about WELLBUTRIN, go to www.wellbutrin.com
or call 1-888825-5249.