Interest of treatment of polytraumatisms with corticoids (hydrocortisone) for patient with relative adrenocortical insufficiency on frequency of nosocomial infection, and hemodynamic complications and organs injuries.

200mg/jour (solution of 48mL), Day 1 to Day 4 100mg/jour (solution of 48mL), Day 5 50mg/jour (solution of 48mL), Day 6

Placebo Comparator: P

Treatment by NaCl (placebo)

Drug: NaCl

48mL from Day 1 to Day 6

Eligibility

Ages Eligible for Study:

15 Years and older

Genders Eligible for Study:

Both

Accepts Healthy Volunteers:

No

Criteria

Inclusion Criteria:

Age superior of 15 years

Hospitalization in reanimation for polytraumatism (lesion of two organs with a vital risk)

SISS score more than 15

Intubation for more than 48 hours.

Agreement of a family member

Patient with insurance

Exclusion Criteria:

History of corticothérapies within 6 months

History of adrenocortical insufficiency.

Treatment by immunosuppressor

Immunodeficiency.

Contacts and Locations

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For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00563303