6/27/2008 @ 4:00PM

In Pictures: America's Oldest Neighborhoods

San Francisco, Calif.

The Mission District

Originally founded by Franciscan friar Junipero Serra, the Mission Delores was the centerpiece to San Francisco’s first settlement in 1776, though it may be better known for its ominous appearance in Hitchcock’s Vertigo in 1958. There aren’t many historic homes in this neighborhood, which today is known for housing artists, hipsters and the large Latino population and culture that’s been there from the district’s inception.