Don't let the horror tag fool you. Requiem is a world of mixed science fiction and fantasy elements - gory, yes, but not terrifying or suspenseful. The back story of Requiem is full of war, technology, and magic, and players come into the story after a tragedy that caused the world to split apart, scattering its races, hiding its secret knowledge, and mutating its wildlife into monsters. Players are part of the Ioxenic genetic reprogramming, utilizing special DNA to create defenders of mere humans caught in this violent world.

Players will only get a feel for this storyline in their first tutorial quests, as they learn the basics of game play and train their skills to learn their first class. Beyond that, the story is mostly forgotten, with generic quests placed into this setting with no feel of heroism or power on the player's part. World areas have little life of their own, and appear to be little more than a dumping ground for NPCs and monsters.