Databases

Coexpression

Proteins whose genes are observed to be correlated in expression, across a large number of experiments.

STRING allows inspection of the interaction evidence for any given network. Choose any of the viewers above (disabled if not applicable in your network).

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:query proteins and first shell of interactors

white nodes:second shell of interactors

Node Content

empty nodes:proteins of unknown 3D structure

filled nodes:some 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

TTX_1818

annotation not available (165 aa)

Predicted Functional Partners:

TTX_0183

annotation not available (453 aa)

0.612

TTX_1819

annotation not available (253 aa)

0.576

elf1

annotation not available (97 aa)

0.538

tfe

Transcription factor E; Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems [...] (178 aa)

a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1

node2

node1 accession

node2 accession

node1 annotation

node2 annotation

score

TTX_0183

TTX_1818

TTX_0183

TTX_1818

annotation not available

annotation not available

0.612

TTX_0510

TTX_1533

TTX_0510

TTX_1533

annotation not available

annotation not available

0.446

TTX_0510

TTX_1686

TTX_0510

TTX_1686

annotation not available

annotation not available

0.545

TTX_0510

TTX_1818

TTX_0510

TTX_1818

annotation not available

annotation not available

0.506

TTX_0510

TTX_1979

TTX_0510

TTX_1979

annotation not available

annotation not available

0.613

TTX_0510

elf1

TTX_0510

TTX_1715

annotation not available

annotation not available

0.593

TTX_0510

rpS30e

TTX_0510

TTX_0151

annotation not available

annotation not available

0.616

TTX_0510

rps30e

TTX_0510

TTX_0161

annotation not available

annotation not available

0.616

TTX_0510

tfe

TTX_0510

TTX_1936

annotation not available

Transcription factor E; Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems [...]

0.610

TTX_1533

TTX_0510

TTX_1533

TTX_0510

annotation not available

annotation not available

0.446

TTX_1533

TTX_1686

TTX_1533

TTX_1686

annotation not available

annotation not available

0.549

TTX_1533

TTX_1818

TTX_1533

TTX_1818

annotation not available

annotation not available

0.498

TTX_1533

TTX_1979

TTX_1533

TTX_1979

annotation not available

annotation not available

0.506

TTX_1533

elf1

TTX_1533

TTX_1715

annotation not available

annotation not available

0.585

TTX_1533

rpS30e

TTX_1533

TTX_0151

annotation not available

annotation not available

0.476

TTX_1533

rps30e

TTX_1533

TTX_0161

annotation not available

annotation not available

0.476

TTX_1686

TTX_0510

TTX_1686

TTX_0510

annotation not available

annotation not available

0.545

TTX_1686

TTX_1533

TTX_1686

TTX_1533

annotation not available

annotation not available

0.549

TTX_1686

TTX_1818

TTX_1686

TTX_1818

annotation not available

annotation not available

0.503

TTX_1686

TTX_1979

TTX_1686

TTX_1979

annotation not available

annotation not available

0.607

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Network Stats

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Functional enrichments in your networkNote: some enrichments may be expected here (why?)

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Statistical background

For the above enrichment analysis, the following statistical background is assumed: