Effective November 6th, 2019 at 2:00 pm Pacific Time, Cohort 1, the acquired resistance cohort of substudy S1400F will permanently close to accrual. Please note that Cohort 2, the primary resistance cohort, has been reactivated and is open to accrual.

S1400F Cohort 2, the primary resistance cohort, will be permanently closed to accrual effective March 24, 2020 at 12:00 p.m. Pacific Time, due to study feasibility.