FE65 small interfering RNA does not influence Rac1 expression or its activity, although it acts as an adaptor protein with several protein-interaction domains.

Fe65 carries out different functions depending on its location in the regulation of Notch1 (show NOTCH1 Antibodies) signaling.

a unique role for the 97 kDa isoform in controlling GnRH-1 (show GNRH1 Antibodies) neurogenesis that is not redundant with the 60 kDa isoform of FE65.

Results confirm that megalin (show LRP2 Antibodies) interacts with APP (show APP Antibodies) and FE65, suggesting that these three proteins form a tripartite complex.

Data show that the carboxyl-terminal half of FE65, which contains the PI2 (show SERPINB1 Antibodies) domain, failed to stabilize p53 (show TP53 Antibodies), suggesting that the amino-terminal half of the protein plays an important role in the stabilization of p53 (show TP53 Antibodies) in osmotically stressed cells.

Targeted enhancement of the signaling through the Fe65-cortactin (show CTTN Antibodies) pathway, by either HDAC6 (show HDAC6 Antibodies) inhibition or Tip60 (show KAT5 Antibodies) activation, may lead to the development of new therapeutic drugs that are effective for patients with metastatic breast cancers.

Jagged1 is a novel binding partner of Fe65, and Fe65 may act as a novel effector of Jagged1 signaling.

Protein Summary

The protein encoded by this gene is a member of the Fe65 protein family. It is an adaptor protein localized in the nucleus. It interacts with the Alzheimer's disease amyloid precursor protein (APP), transcription factor CP2/LSF/LBP1 and the low-density lipoprotein receptor-related protein. APP functions as a cytosolic anchoring site that can prevent the gene product's nuclear translocation. This encoded protein could play an important role in the pathogenesis of Alzheimer's disease. It is thought to regulate transcription. Also it is observed to block cell cycle progression by downregulating thymidylate synthase expression. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene.