The story centers around a poor teenage girl named Shan Chai (Barbie Hsu), who at the insistence of her parents goes to a university for rich people. The university is dominated by Dao Ming Si (Jerry Yan), Hua Ze Lei (Vic Zhou), Mei Zuo (Vanness Wu) and Xi Men (Ken Chu), four rich and handsome but arrogant students collectively known as 'F4', short for 'Flower 4'. They are heirs to four rich and influential families in Taiwan. They terrorize the school by handing out red cards to those they do not like, which allows other students to bully the victims until they leave the school.

After one of Shan Chai's friends receives the wrath of F4's leader, Dao Ming Si, and receives a red card, Shan Chai stands up to Dao Ming Si and slaps him, which in turn results in a red card of her own. However, Shan Chai's persistence in standing up for what is right gradually gains F4's respect and Dao Ming Si falls in love with her.