Lopāmudrā was the wife of the famous sage Agastya. She was the daughter of the king of the Vidarbha country.

According to one story, Agastya once saw his forefathers in a miserable condition. On enquiring about their plight, they advised him to marry and beget sons who would deliver them from this misery. He then approached the king of Vidarbha and requested him to give his daughter Lopāmudrā in marriage. Though the king was hesitant, Lopāmudrā herself came forward accepting the proposal. The two were married at the place called Mahāsindhutīrtha.

Dṛḍhasyu or Idhmavāha was their son. She was also known as Satyavatī. She is sometimes identified with Kāverī, daughter of the sage Kavera, who became the river Kāverī.