When comparing Appcelerator Titanium vs Fuse, the Slant community recommends Fuse for most people. In the question“What are the best frameworks for developing cross-platform mobile apps with JavaScript?”Fuse is ranked 9th while Appcelerator Titanium is ranked 19th. The most important reason people chose Fuse is:

A key difference is that Fuse uses JS exclusively for app logic while producing native code for everything else, including population and manipulation of the UI.

Pros

Pro

Provides a native experience

Through using Titanium's API and UI components similar to that of the platform's native UI, Titanium provides a native experience.

Pro

Compiles to native platform code

A key difference is that Fuse uses JS exclusively for app logic while producing native code for everything else, including population and manipulation of the UI.

Pro

Native performance

Pro

OpenGL UI

With the option to use OpenGL based UI components, Fuse is the only of the three platforms that offer a reliable “write once, run everywhere” approach where designers can control responsive layout, look and feel down to points, pixels and percentages, keyframes and easing curves.

Cons

Con

Commercial

Prices start at $39/month for an indie subscription. For a team account, the price is $249/month per seat.

Con

Most plugins are paid

Appcelerator Marketplace is meant to sell to developers 3rd party plugins and functionalities as well as code samples. Thus, people will prefer to sell you their plugins and samples instead of making them open source. This will increase costs of development.