Roughly half of the proteins recognized as belonging to the ADAM family do not contain the catalytic-site consensus sequence for metalloproteases (HEXXH) in their metalloprotease domain, and are likely not catalytically active. The metalloprotease motif (HELGHNFGAEH) in mouse ADAM17 occurs at amino acids 405-415 ( 9 ; 10 ) . Crystal structure of the ADAM17 metalloprotease domain shows an active site containing zinc and water atoms that are necessary for the hydrolytic processing of protein substrates, and which are coordinated by three conserved histidine residues and the downstream methionine found in the Met turn motif (aa 433-437). The Met turn motif loops around to face the zinc binding ...

The VW MAN Thread
The VW MAN Thread
VW and MAN join forces in 1977 to produce a medium sized truck — a market that is untapped by Volkswagen and not visited by MAN since the 1960’s, having concentrated on heavier trucks, with partner Saviem of France, from 1968 to 1975 (when Saviem joined Berliet at Renault).
1978
VW’s LT range grows to fill the gap between the LT35 and the forth-coming range with LT40 and 45 versions and the addition of a 2.4 litre 6-cylinder diesel engine (also used by Volvo in their 200 and 700 series cars) to replace the Perkins unit.
1979 — 1993
VW-MAN G series — or MT — is launched using a wide version of the LT cab on a MAN chassis ...

Difficulty Level 3-4
Figure 1: Standard 3 Gauge Set on the 914
Many Porsche owners have had problems with the gauges that are located in the dashboard of their cars. This Pelican tech article will provide some hints and tips on the following topics related to the VDO gauges found in almost all Porsches:
Gauge Face Replacement Refurbishment
Odometer Repair
Speedometer Calibration and Check
Speedometer Recalibration for Different Tires
Temp/Oil/Gas Module Replacement Substitution
Figure 19: Final Assembly of Odometer Drive
Figure 20: Side View of Final Assembly of Odometer Drive
The first repair job I ever attempted on my 914 was the repair of my odometer. I had just gotten to LA, ...

Timeline
MWM INTERNATIONAL: 60 YEARS OF BRAZIL
The 50’s
In 1953, MWM settled in Brazil as MWM Motores Diesel SA. Initially, the partners were WMF (German company with operations in Brazil) and MWM from Germany and Knorr-Bremse AG group.
A year later, MWM started a project to build KD12-series engines. In Germany, KD12 was the state-of-the-art engine. In Brazil, the engine was sold for industrial, agricultural and marine use.
MWM office was installed on Florêncio de Abreu Street in downtown São Paulo. In 1955, the company acquired a land in Jurubatuba (Santo Amaro) suburb, where the company remains installed until today.
The engines’ assembly with nationalization rate of ...

Chassis Engine Serial Numbers
Since the 1945 Volkswagen Vehicles have carried their identification serial numbers in a number of different formats. The following details only apply to German production, others vary.
Type 1 (Cars) to 31st July 1964
Chassis / VIN Numbers.
Until 31st December 1955 Chassis (VIN) Numbers were six digit (and a few at the end of the period seven digits) prefixed with 1 -, that is the digit 1 and a dash. i.e. 1-063 289
1st January 1956 to 31st July 1964 The 1- was dropped and vehicles numbered sequentially.
See ‘Appearance of Serial numbers on the car/van in documentation’ below.
The location of the chassis (VIN) number on Type 1 vehicles was originally ...

PERODUA VIVA – IS THE 6TH GENERATION OF DAIHATSU CUORE/MIRA
The 6th generation of Daihatsu Mira
Perodua Viva is one of the car that most Malaysians like due to its small fuel consumption.It is ranks among the most economical automobiles on the market. Perodua Viva is the rebadged sixth generation of the Daihatsu Mira /Cuore. It was released not long after seventh generation JDM Mira was announced in Japan.
The Daihatsu Mira (also known as the Cuore, Domino or Charade outside of Japan), is a kei car-type vehicle built by the Japanese car maker Daihatsu . It comes with a variety of options and chassis variations, with the latest variant having four models: “ Mira “, “ Mira AVY “, ...

Peterbilt
Peterbilt Motors Company, founded in 1939, is an American manufacturer of medium- and heavy-duty Class 5 through Class 8 trucks headquartered in Denton, Texas. Peterbilt operates manufacturing facilities in Denton, Texas (1980), and Sainte-Thérèse, Quebec. From the early 1960s until the mid-1980s, the company was based in the San Francisco Bay Area of Northern California. with its headquarters, and main plant all in Newark, California. The Newark plant closed in 1986 and consolidated manufacturing at its facilities in Denton, TX and Madison, TN. In 1993 headquarters and engineering also moved to Denton. The Nashville plant was closed in 2009.
History Edit
In the early part ...