7
Fatty liver disease Fatty liver is reversible if the patient stops drinking, other causes Fatty liver can lead to steatohepatitis Steatohepatitis is fatty liver accompanied by inflammation Steatohepatitis can lead scarring of the liver and developed cirrhosis

8
Symptoms and Signs Usually asymptomatic Right upper quadrant pain or discomfort Fatigue or maliase Symptoms of associated condition Hepatomegaly with or without tenderness Signs of chronic liver disease

11
Prevalence of NAFLD The most common liver disease in developed countries 20 – 40% in western industrial countries 5 – 30% in Asia – Pacific region Age 40 – 60 yrs, common in men Alcohol consumption less than 20 gm/week

29
Summary Fatty liver disease is the most common liver disease in developed countries Fatty liver disease can be lead to liver cirrhosis The major risk factors are obesity, DM type2, dyslipidemia and metabolic syndrome No proven effective therapy Treatment are modify risk factors and weight reduction