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The Record Date for determining the stockholders entitled to notice of, and to vote at, the Annual Meeting has been set as the close of business on September 13, 2013.

Proposals for action by stockholders include: the election of five Directors; the ratification of McGladrey LLP to audit the financial statements of Hemispherx; the approval, by non-binding vote, of executive compensation; and approval of the HEMISPHERx 2013 Equity Incentive Plan intended to conserve cash as well as attract and retain individuals of experience and ability to provide incentive to our employees, consultants, non-employee directors and vendors of the Company to obtain proprietary interests in the Company.

The mailing of the proxy material commenced on September 16, 2013. The Company has posted copies of the proxy statement, the annual report for the fiscal year ended 2012 and the quarterly report for the quarter ended June 30, 2013 on its website at
http://www.hemispherx.net/content/investor/annualmeeting.asp .

The Company emphasizes the importance of your vote!

If you are a U.S. resident and received a proxy card containing your Control Number, please take a moment to vote your shares via Internet, phone, or mail. If you are a non-U.S. stockholder, you are encouraged to contact your custodian bank/broker at your earliest convenience.

Important Information for Foreign Stockholders

Hemispherx urges all stockholders who owned shares on September 13, 2013, the Record Date for the Meeting, to vote. A significant number of stockholders are domiciled in Europe and are less readily accessible for notification purposes.

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