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MatTek Corporation is pleased to announce the launch of its new in vitro Psoriasis Tissue Model. The tissue model consists of normal, human-derived epithelial cells and fibroblasts from psoriatic tissue which have been cultured to form a multilayered, highly differentiated model of human psoriasis–like tissue. The Psoriasis Tissue Model exhibits increased levels of psoriasis associated markers such as basal cell proliferation (Ki67), human beta defensin-2 (HBD2), SKALP/elafin, psoriasin, and activated STAT3 and elevated cytokine release (IL-8, IL-6, GM-CSF, and IP-10). The tissue model is also responsive to therapeutics such as Calciptriol Hydrate.

MatTek’s Psoriasis Tissue Model will serve as a cost-effective and easy-to-use tool to screen therapeutic candidates for safety and efficacy.

Are you attending the 2012 Society of Investigative Dermatology Annual Meeting? Stop by poster # 368 to learn more about MatTek’s Psoriasis Tissue Model or request a copy of the poster here!

MatTek In Vitro Life Science Laboratories (IVLSL) Established in Slovakia

Located in the heart of Europe, MatTek IVLSL is now manufacturing and distributing MatTek’s in vitro EpiDerm tissue model from its new facility in Bratislava, Slovakia. Our European customers can now receive EpiDerm tissue with overnight delivery to all locations. Our highly experienced scientists at IVLSL are available for consultation and technical support. EpiOcular and other tissue models are expected to be manufactured at IVLSL in early 2013!

Testing For Regulatory Purposes Has Never Been More Cost Effective!

In an effort to promote the use of in vitro methods for regulatory testing, MatTek together with several of our qualified Contact Testing Labs is now offering an attractive discount on ECVAM validated and EU/OECD accepted methods. The discounted pricing applies to the following tests:

Skin Corrosion Test -- OECD TG 431 / EU Method B.40

Skin Irritation Test -- OECD TG 439 / EU Method B.46

For additional information and terms and conditions, please contact MatTek or one of our qualified Contract Testing Labs!

In an effort to provide our customers with an efficient and informative place to learn about our normal, human 3-dimensional (NHu-3D) products and applications, we are currently overhauling the mattek.com website (current website will remain fully functional during this process). New updates will include a user friendly format with simple and intuitive navigation, modern, clutter-free pages and high-resolution, scientifically relevant images and video clips.

Society of Toxicology 2012

Thanks for your support in San Francisco! It was great meeting many new faces and catching up with clients and partners.

If you would like to review our technical presentations, please visit our SOT2012 page!

About MatTek

MatTek is the world’s largest independent producer of normal, human cell-based, 3D (NHu-3D) in vitro models. For nearly 20 years, MatTek has provided an array of organotypic tissue models that closely approximate the target in vivo tissue in terms of their phenotypic, metabolic, and genetic profiles. MatTek’s faithful adherence to using normal human cells (not transformed or immortalized) in a true 3D structure, is reflected in its organotypic models (skin, eye, airway, gingival, vaginal, oral, etc.) as well as normal human dendritic cells (DC-100). Tissue models are available in 96-well high throughput screening formats. Visit our website at www.mattek.comfor more information on our products and services.

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