Anova Stem Cell Therapies:

The Science of a Better You

Anova Stem Cell Therapies: The Science of a Better You

Regenerative Medicine is an exciting new field of medicine with one goal in mind: to heal and restore normal function of damaged tissues and organs. Just like the human body itself, regenerative medicine utilizes stem cells to replace damaged cells and tissues. Stem cells are, therefore, considered to be one of the most powerful tools in treating diseases. They go beyond conventional methods to repair and regenerate disease-related damage, by returning tissues and organs to a healthier and more youthful state.

Which Stem Cells: Spoilt for Choice?

Stem cells exist in many different types as they have been indentified in various tissues and organs. Each type of stem cell is classified by: their origin in the body, and their potential (potency) to differentiate (transform) into other cell types. This potential varies among stem cell types.

Some stem cells are capable of differentiating themselves into any cell type of body (pluripotent). Others, on the other hand, are able to transform into many cell types (multipotent), while some are only able to differentiate themselves into few (oligopotent) or one cell type (unipotent).

Having this in mind, it is important to note that not all stem cell types are suitable for treating patients. For example, the use of Embryonic Stem Cells (ESCs) for treating patients is restricted due to ethical issues, and their potential to grow into tumors.

One of the safest and most effective forms of stem cell treatments, which we employ at Anova IRM, make use of autologous stem cells, i.e. stem cells derived from the patient themselves. By using autologous stem cells for the treatment of patients, there is no need to worry about tumor formation, the transmission of infectious diseases or adverse immune reactions.

Anova’s Stem Cell Treatments: Effective and Safe

Bone Marrow Concentrate (BMC) and Mesenchymal Stem Cells (MSCs) are the most abundant form of autologous adult stem cells that are well suited for clinical use. They are easily harvested from the subcutaneous ("under the skin") fat.

Currently, all therapies at Anova IRM are based on cell-free secretion of MSCs. In the near future we are offering combination therapies with Platelet Rich Plasma (PRP), a medium that is rich in growth factors and other cytokines (molecules from the immune system) that stimulates healing, as well as BMC. Both can additionally be supplemented with our stem cell treatments as they seamlessly synergize together.

Anova IRM offers individualized stem cell therapies that are best suited for the particular condition of the patient, and for the patient only. The administration and application of these therapies depends entirely on the patient’s medical condition, and are in full accordance with the current regulatory authorities.

Stem Cell Therapies by Source

Overview

Numerous types of stem cell therapies are available at Anova. Stem cell research brought insights that allowed for technological advancements in therapies and expanding the knowledge of the underlying mechanisms of stem cells. This has allowed for more effective therapies to be developed.

Stem Cell Therapies 2.0: The Anova Stem Cell Secretome (SCS) therapy is a next generation of stem cell-based therapies. It was designed to harness and mass produce the healing essences of stem cells (paracrine and regenerative factors, extracellular vesicles) in the tens of billions, in a uniquely designed laboratory process, for you.

Fat (adipose) derived Mesenchymal Stem Cells (MSC | adMSCs) are a commonly used source of stem cells, because of their availability and robustness. They communicate to other cells with a broad spectrum of secreted paracrine and regenerative factors. They are our favorite source of stem cells for the production of the secretome.

How Do Stem Cells Heal?

Stem Cells, as explained previously, have the power to differentiate into any cell type, all the way from: bone cells to brain cells, heart cells, nerve cells, kindney cells, etc. This is what defines Stem Cells. However, the potency to differentiate into any body cell type is not what defines their healing powers, as not all stem cell types are able to transform into any cell type. Only a selected few, such a Bone Marrow (BMC) and Mesenchymal Stem Cells (MSCs), have been identified to differentiate into most cells type and have been sucessfully used in medicine to treat diseases. They have been shown to hold several major therapeutic effects, such as:

Induce angiogenesis (development of new blood vessels) - leading to better blood supply

Promote neurogenesis (development of new nervous tissue)

Neuroprotection

Antioxidation

After initial damage to tissues or organs, such as mechanical forces in trauma or the lack of blood supply in strokes and heart attacks, further damage is caused by immune processes and inflammation. Subcritically injured cells, which are usually found in the vicinity of the damaged tissue or organ, primarily commit suicide instead of repairing themselves. This process further increases the damaged tissue volume. To repair this damage, which is (potentially) possible in most organs by the specific stem cells residing in them, is very slow or does not happen at all without external stimulation. In such cases, stem cells therapies have been demonstrated to be extremely effective in stimulating repair and limiting further damage.

Early stem cell research indicated that stem cells heal by replacing damaged cells in injured organs. Now, it has become evident that the major effects of tissue repair are not entirely based on direct stem cell implantation, but rather by the secretion of soluble (paracrine) factors from the stem cells themselves.

This discovery has prompted the Anova scientists to explore a completely new therapeutical approach in regenerative medicine, which has ultimately lead to the development of our novel stem cell-free treatment: The Anova's Stem Cell Secretome Therapy.

Anova’s Stem Cell therapy method utilizes autologous stem cells, i.e. cells that are derived from the patient itself, to mass produce the secretory factors (that retain the regenerative powers of stem cells), in the range of tens of billions. At Anova, a minimally invasive mini-liposuction procedure is performed, which allows for the isolatation of stem cells from the subcutaneous fat (adipose tissue) of the patient.

This method does not rely on direct stem cell transplantation to treat numerous diseases and support anti-aging. Latest scientific research has shown that stem cell-free therapies, such as at Anova's, offer the same efficacy as traditional stem cell transplantation therapies, with higher safety and minimized risk for the patient.

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