Posts: 14

Topic: ABC 03 Trial - recruiting September time

NB: The information displayed below does not replace the protocol. The latest protocol version should always be consulted before making clinical decisions. ABC-03 Randomised phase II trial of cediranib (AZD2171) vs. placebo in addition to cisplatin/gemcitabine chemotherapy for patients with advanced biliary tract cancers

Re: ABC 03 Trial - recruiting September time

Hi Andie,

Many thanks for taking the time to find this out and for posting the information here. Much appreciated and I am sure it will be of use to some in the UK

Best wishes to you and your dad,

Gavin

Any advice or comments I give are based on personal experiences and knowledge and are my opinions only, they are not to be substituted for professional medical advice. Please seek professional advice from a qualified doctor or medical professional.

Re: ABC 03 Trial - recruiting September time

Hi Gavin,

No problem it's a pleasure to try and help.

I was hoping my Dad would be able to take part as originally it mentioned a June start but an email I received today mentioned it would be recruiting in September, so it will be too late as Dad will need to start his Chemo before then.

Hopefully it will be of help to someone.

It I recieve anymore emails regarding the trial I will update

Best wishes

Devoted Daughter to the most wonderful Dad a girl could ask for. Sadly lost his battle on 19.02.11, peacefully in the arms of Mom and I. As requested by Dad "we will keep on smiling".

Re: ABC 03 Trial - recruiting September time

Thank you so much for this information, Andie. Unfortunately, by September, my sister's chemo will still have been within 6 months of the recruitment - & she had the Gem/Cis combo which seems to exclude her, too. But I'm so grateful to you for seeing, assessing & posting this.

I hope your dad feels a lot better now.

Julia x

“When it is dark enough, you can see the stars." - Ralph Waldo Emerson

Re: ABC 03 Trial - recruiting September time

I've just read your other post, so pleased your sister is doing so well, it's wonderful news to hear.

My Dad is feeling very well and is carrying on with all normal day to day activities. You wouldn't know he had CC if you hadn't been told.

The main problem is the Chemo, or lack of! We went to see the Oncologist today and he's referring Dad back to the liver hospital as his bilrubin is still too high for chemo (75). We have got to go Friday to see what they say. I presume it will be due to a blocked stent. Dad is getting anxious now though that he was diagnosed and stented in April and he still hasn't has any treatment. Fingers crossed they can sort out the stent and start Chemo soon.

Best wishes to you and your sister.

Devoted Daughter to the most wonderful Dad a girl could ask for. Sadly lost his battle on 19.02.11, peacefully in the arms of Mom and I. As requested by Dad "we will keep on smiling".

Re: ABC 03 Trial - recruiting September time

Thank you, Andie. What a rollercoaster!!!

At Kings, they kept telling my sis they wouldn't start chemo until her bili was down to 50. I think she was about 257 at the time (I'm trying to dredge up a memory from a time I've spent the past year trying to blot out ) In the end they didn't wait until 50, although I can't remember the actual number.

I'm keeping everything crossed for you Dad.

Jx

“When it is dark enough, you can see the stars." - Ralph Waldo Emerson

Re: ABC 03 Trial - recruiting September time

Hi Julia,

Dad had his blood tested today so will know Monday if bilirubin has gone up or down. I think it's gone up as his eyes have a slight yellow tinge starting to appear.

The next step will be his stent being unblocked, he may have to go to another hospital for this if they can't slot him in at the birmingham hospital Because dad feels well I think he'd prefer to wait for Birmingham to do it but i've told him it's important to have his stent unblocked so chemo can start and the longer he wiats the longer it will take to come down. They won't start at anything above 50 as the normal limit is 35. Even if they can see it is going down 50 is the magic number!

The good thing is the doctor and nurses were pleased to see dad looking well (apart from slight eye tinge!) and eating well, I hope this continues.

Thank you for thinking of us.

Best wishes to you and your family

Devoted Daughter to the most wonderful Dad a girl could ask for. Sadly lost his battle on 19.02.11, peacefully in the arms of Mom and I. As requested by Dad "we will keep on smiling".

In ABC-03, the aim will be to see if adding cediranib to CisGem will be more effective than CisGem alone. Cediranib is an unlicensed VEGF inhibitor. This trial is part of the NCRN/AstraZeneca collaboration

Re: ABC 03 Trial - recruiting September time

Thanks for this Andie. Pity that the trial start date has been delayed until March 2011 and hopefully there will be no more delays from there. And hopefully you will be able to find out more info on this Marion when you go to Chicago.

Thanks to you both,

Gavin

Any advice or comments I give are based on personal experiences and knowledge and are my opinions only, they are not to be substituted for professional medical advice. Please seek professional advice from a qualified doctor or medical professional.

The information expressed is not medical advice. The discussion boards are not intended to replace the services of a trained health professional or to be a substitute for the medical advice of physicians or other healthcare providers. Read the full disclaimer.