Lisa A MaierDepartment of Medicine, National Jewish Medical and Research Center, Department of Medicine and Department of Preventive Medicine and Biometrics and University of Colorado Health Sciences Center, Denver, CO, USAClin Chest Med 23:827-39. 2002

..We previously found high neopterin levels in CBD patients' serum and questioned whether Be-stimulated neopterin production by peripheral blood cells in vitro might be useful in the diagnosis of CBD...

Genetic and exposure risks for chronic beryllium disease

Lisa A MaierDepartment of Medicine, National Jewish Medical and Research Center, Department of Medicine and Department of Preventive Medicine and Biometrics and University of Colorado Health Sciences Center, Denver, CO, USAClin Chest Med 23:827-39. 2002

..Current genetic markers are not ready for clinical use as a screening test for beryllium-related health effects because of the low specificity of the markers and the low prevalence of BeS and CBD...

..9%. CONCLUSIONS: These data suggest that pulse oximetry cannot be used reliably to distinguish between CBD and BeS and, thus, is not an adequate substitute for arterial blood gas analysis with exercise...

..As a result of the small sample size and strong linkage disequilibrium between DRB1*13-DQB1*0603/4/9 and the BTNL2 rs3117099T allele, it is difficult to assess the primary association in DPB1*Glu69-negative CBD cases...

..Despite numerous studies in human beings linking surface phenotype of blood T cells with their functional characteristics, little is known about this relationship on antigen-specific CD4(+) T cells residing in a target organ...

..20. In conclusion, increased cumulative and LTW exposure to total and respirable beryllium was observed in workers with CBD or BeS compared with the controls. These results support efforts to control beryllium exposure in the workplace...

..Together, these findings indicate that the functional capability of antigen-specific CD4+ T cells is determined by the relative proportion of memory T cell subsets, which may reflect internal organ involvement...

..Rather, it establishes pathways leading to chronic granulomatous inflammation. We will examine recent studies describing the host's cellular and molecular responses to Be, responses that promote granuloma formation...

Beryllium-induced tumor necrosis factor-alpha production by CD4+ T cells is mediated by HLA-DP

..Beryllium medical surveillance detects sensitization and CBD in cleanup workers. Exposure controls and medical surveillance need to be 'broad-based' to include all cleanup workers involved in beryllium-contaminated building remediation...