One man was charged Saturday and police were looking for a second suspect in connection with an attempted robbery and a chase that ended in a fatal freeway wreck.

Benito Garza, 36, was hit with a litany of charges stemming from the Friday night incident — including murder, aggravated assault and aggravated robbery, police said.

It was the second fatal wreck involving a suspect fleeing police in a single week.

Police said they came upon Garza and another man as they attempted to rob a home in the 5100 block of Sagamore Drive on the Southwest Side, and they believe shots were fired.

Garza fled, police said, and they are still investigating at what point the second suspect made his getaway. Garza was chased until his vehicle entered the southbound lanes of northbound Loop 410, crashing into several vehicles and a motorcycle carrying Pedro and Roxanne Tenorio, police said.

Pedro Tenorio, 55, the driver, was killed. Roxanne Tenorio, 41, was critically injured and flown to University Hospital, where she was in guarded condition Saturday, police said.

According to the preliminary accident report, they were thrown off the bike, and Pedro Tenorio appeared to have been run over by the car behind him. Roxanne landed on that car and smashed into the windshield, the report says.

Garza continued driving against traffic in his mother's Hyundai Elantra, stopping only after he struck a guardrail, police said.

“Witnesses saw where he went and we were able to apprehend him while he was trying to climb over a fence, still holding the shotgun,” Police Chief William McManus said Friday night, adding that the gun was loaded.

On Saturday, Garza's brother said he suffered from epilepsy and other medical problems resulting from a beating with a bat at a bar in 2005.

“I don't know (if he could have done this), he's not all there,” Pedro Ortega said. “I can't tell you if my brother had the heart to do that or not.”

He said the last time he saw Garza was about 3:30 p.m. Friday, four hours before police reported the attempted robbery occurred.

“He's real sick, and if they don't give him the pills, he's not going to wake up,” said Frances Garcia, Garza's mother. “I don't know how he's doing. He hasn't called me.”

During a canvas of more than 25 houses on Sagamore on Saturday, most neighbors said they weren't home at the time of the incident or weren't aware it was happening.

“I was kinda freaked out, but that was about it,” said Alexandra Zuniga, 16, who lives just a few doors down from the house.

Police said they chased Garza along Old Pearsall Road until he entered the northbound lanes of Loop 410, headed south.

McManus said Friday that police did not follow Garza onto the freeway because of the risk to the public, but remained in the area and continued to monitor him.

Earlier this week, an SUV in a high-speed chase with police sideswiped a Volvo at 80 mph. One child in the Volvo died at the scene and a second died two days later at University Hospital, where he had been on life support.