Black Sigatoka (BS) Mycosphaerella fijiensis (anamorph Pseudocercospora fijiensis) is the most limiting disease for banana production in Puerto Rico. A field experiment was established at Isabela Station to study a spray program based on the systemic and contact fungicides registered in Puerto Rico for BS control. The experimental design was a RCB with four replicates and six treatments. Treatments evaluated were: 1. Rotation azoxystrobin (Abound) + Contact Fungicides mancozeb (Dithane F-45) or chlorothalonil (Bravo weatherstik); 2. Rotation propiconazole (Tilt) + chlorothalonil or mancozeb; 3) Rotation azoxystrobin (Abound) + propiconazole (Tilt) + chlorothalonil or mancozeb; 4. Contact Fungicides chlorothalonil or mancozeb; 5. Orchard oil BVA #15 and 6. Absolute control (untreated plots). Fungicide applications were conducted from ground level with a motorized backpack sprayer calibrated to deliver a total volume of 85-110L/ha. Fungicides were sprayed in an oil-water emulsion, an oil mixture, or in a water-emulsion, at intervals of 14 days during rainy season and 21 days during dry season. A total of eight sprays were applied during the banana plant crop. Two of these sprays were made with systemic fungicides (Tilt or Abound) and the rest were with the contact fungicides (mancozeb and chlorothalonil ) Results indicated that temperature played an important role on disease development in Puerto Rico. Relative Humidity (RH) had a good Spearman’s coefficient value (rho=0.62) with YDL; indicating that RH is important during the first stages of BS development. Rho values for rainfall were in general low, indicating that this variable is not very good to predict BS development during the development of the banana plant crop at Isabela, Puerto Rico. The spray program with mancozeb and chlorothalonil (treatment 4) reached the best values for bunch weight when compared with the other treatments studied. A bunch weight reduction of 44.7% was observed when the absolute control, treatment 6 (16.11 kg/bunch) was compared with treatment 4 (29.15 kg/bunch), indicating the importance of BS control on bananas in Puerto Rico.