Applications

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application

Abreviews

Notes

WB

1/500 - 1/2000. Predicted molecular weight: 49 kDa.

Target

FunctionProbable serine protease that play a role in hearing. Acts as a permissive factor for cochlear hair cells survival and activation at the onset of hearing and is required for saccular hair cell survival (By similarity). Activates ENaC (in vitro).

Tissue specificityExpressed in many tissues including fetal cochlea. Isoform T is found at increased levels in some carcinomas.

Involvement in diseaseDefects in TMPRSS3 are the cause of deafness autosomal recessive type 8 (DFNB8) [MIM:601072]. DFNA8 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.Defects in TMPRSS3 are the cause of deafness autosomal recessive type 10 (DFNB10) [MIM:605316].

Thank you for your patience.
I heard back from the lab regarding ab24158: There is no homology with mouse.
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Thank you for your enquiry.
This product was raised in rabbit against a mixture of two synthetic peptides : NH2-MGENDPPAVEAPFSFC-COOH (amino acids 1-16 of human TMPRSS3) and NH2-CFLDWIHEQMERDLKT-COOH (amino acids 439-454of human TMPRSS3).
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