Postdoctoral Position: Epigenetic(Trans)Gene

Postdoctoral Position: Epigenetic (Trans)Gene
Silencing
An NSF-funded Postdoctoral position is available
immediately to study
the molecular mechanisms responsible for epigenetic
(trans)gene
silencing. In plants, transgenes are silenced at both
transcriptional
and post-transcriptional levels. Similar mechanisms
appear to control
the expression of transposable elements and might also
be involved in
the developmental regulation of gene expression. The
project will
entail functional genomic approaches, such as
transposon-mediated
insertional mutagenesis, for the isolation of genes
involved in
epigenetic silencing, the molecular characterization
of the mutants,
and
the identification of interacting proteins by affinity
purification/MS
sequencing. Arabidopsis thaliana and the unicellular
green alga
Chlamydomonas reinhardtii are being used as model
systems. We have
recently cloned a novel DEAH-box RNA helicase that is
required for
transgene and transposon silencing in Chlamydomonas
(Wu-Scharf et al.,
Science 290, in press [2000]). The successful
candidate will have
access to state-of-the-art facilities in the George W.
Beadle Center
for
Genetics Research and acquire experience in chromatin
analyses,
proteomics, and functional genomics. A background in
molecular
genetics
and biochemistry is desirable. Applicants should send
a CV, statement
of research experience, and three letters of reference
to: Dr.
Heriberto Cerutti, School of Biological Sciences,
University of
Nebraska-Lincoln, E211 Beadle Center, P.O. Box 880666,
Lincoln, NE
68588-0666; phone (402) 472-0247; fax (402) 472-8722;
e-mail
hcerutti1 at unl.edu. Review of applications will begin
October 1, 2000,
and will continue until a suitable candidate is found.
UNL is
committed
to a pluralistic campus community through Affirmative
Action and Equal
Opportunity and assures reasonable accommodation under
the Americans
With Disabilities Act.
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Moderated
bionet.genome.gene-structure
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