The microsomal membranes were prepared from
liver and brain tissues in two age groups of young(2-3
weeks) and adult(6-7 months) rats.
The activity of microsomal g]ucose-6-phosphatase
(G-6Pase) was determined and the microsomal lipid
composition was analyzed by means of TLC and gas
chromatography
The results were discussed in special reference to
age-related changes. and are summarized as follows
1. The marked difference in liver weight was
observed between two age groups. showing active
growing of liver tissue in young rats whereas no
appreciable increase in brain weight was seen in
adult rats, indicating the halt of brain tissue growth
in very early stage of life.
2. The specific activity of G-6-Pase was much
higher in young rat liver than in adult one and the
slightly higher level of this enzyme was also observed
in young rat brain. but much lesser extent than in
liver.
The differenee in the specific activity of the enzyme
was discussed in relation to development of the
tissues