The migration of living cells plays an important role in immune response, hemostasis, cancer progression, delivery of nutrients, and microfluidic technologies such cell separation/enrichment and flow cytometry. Using three-dimensional computational...

The active human retrotransposon L1 is the most prevalent human retroelement, constituting 17% of the mass of the human genome and contributing significantly to mutagenesis. L1 mutagenizes human genomes in a number of ways including insertional...

MicroRNAs (miRNAs) are a group of small, noncoding RNAs that modulate the translation of genes into proteins by binding to specific target sites in messenger RNAs. This study investigated the biological function and molecular mechanism of...

Regulatory T cells (Tregs) suppress effector immune responses and have been implicated in promoting chronic viral infections. Their role during influenza infection and vaccination, however, is still unclear. Influenza is a major public health...

Lyme disease is the most commonly reported vector-borne disease in the United States. The causative agent of Lyme disease, can alter gene expression to enable survival in a diverse set of conditions, including the tick midgut and the mammalian...

Astrocytes display a complex, stellate morphology in the brain, commensurate with their role in regulating nearly every functional aspect of the central nervous system. Innate activation of astrocytes is a classic hallmark of neurologic injury and...

Soft tissue reconstruction in the nervous system is sensitive to the mechanical and chemical cues of the growth microenvironment. Many technologies have been designed to study these stimuli and their effect on the regional extracellular environment...

An understanding of the pathways responsible for differentiation in pluripotent stem cells (PSCs) would accelerate their translation to medical therapies. Specifically, studies that identify criteria for the better design of experiments targeting...

Triple-negative breast cancer (TNBC) accounts for 15% of all diagnosed breast cancers nationally and affects African-American women 3 times more likely than any other ethnic group. Locally, African-American women in the New Orleans area see higher...