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Abstract

Ultrahigh-resolution optical coherence tomography (OCT) by use of state
of the art broad-bandwidth femtosecond laser technology is demonstrated and
applied to in vivo subcellular imaging. Imaging is performed
with a Kerr-lens mode-locked Ti:sapphire laser with double-chirped
mirrors that emits sub-two-cycle pulses with bandwidths of up to 350 nm,
centered at 800 nm. Longitudinal resolutions of ∼1µm and transverse resolution of 3µm, with a 110-dB dynamic range, are achieved in biological tissue.
To overcome depth-of-field limitations we perform zone focusing and image
fusion to construct a tomogram with high transverse resolution throughout
the image depth. To our knowledge this is the highest longitudinal resolution
demonstrated to date for in vivo OCT imaging.

References

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