At the beginning of this long-term study, 1,321 older adults were free from dementia. The study was in France, where manufacturers are not required to fortify foods with folate. Participants filled out a dietary questionnaire, took a psychological test, and interviewed with doctors to determine socio-economic, lifestyle, and health characteristics. After 7.4 years, people who consumed the most folate were half as likely to have developed dementia compared to those who consumed the least folate.

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