Abstract:The National Cotton Council Disease Loss committee submitted estimates of the losses due to each disease during the 2016 growing season. Disease incidence estimates are determined by cotton specialists in each state discussing disease incidence observed across each state during the year. Yield losses are calculated by using the USDA “Crop Production” published at http://usda.mannlib.cornell.edu/usda/current/CropProd/CropProd-12-09-2016.pdf which documents cotton acreage planted, harvested, and average yields for each state. Cotton acreage harvested is expected to total 9.46 million acres, which is an increase of 19 % from 2015. Record high upland cotton yields were expected in Alabama, California, Oklahoma and Tennessee. Total average percent loss was estimated at 12.5%, which is up 3.3 % from 2015. Plant parasitic nematodes were the group of pathogens responsible for the largest average percent loss estimated at 4.30% follow by boll rots at 3.07% disease losses. Missouri suffered the greatest total disease losses of over 20%. Alabama, Arkansas, Florida, Georgia, Louisiana, Mississippi, South Carolina, Tennessee, Texas and Virginia all estimated losses over 10%. Arizona, California, New Mexico, and Oklahoma, appeared to have the best growing conditions with the least amount of disease losses. In Oklahoma the largest disease loss, this year was due to bacterial blight. This disease was reported from most of the 90,000 irrigated acreage in the state. Based on the USDA Planted 2017 Beltwide Cotton Conferences, Dallas, TX, January 4-6, 2017 150 Varieties Survey for 2016, about 67,500 irrigated acres were planted to susceptible varieties dominated mostly by DP 1522 B2XF and NG 3406 B2XF. In severely infected fields, producers lost up to a bale/acre based on their estimates when comparing yields from resistant varieties (mostly DP 1518 B2XF) planted in nearby fields.