War between Charles V and Francis I of France that began with the death of Francesco Maria Sforza, the duke of Milan. When Charles' son Phillip inherited the duchy, Francis invaded Italy, capturing Turin, but failed to take Milan. In response, Charles invaded Provence, advancing to Aix-en-Provence, but withdrew to Spain rather than attacking the heavily fortified Avignon. The Truce of Nice ended the war, leaving Turin in French hands but effecting no significant change in the map of Italy.