In Samoa, obesity epidemic begins at birth

BROWN (US) — In American Samoa, approximately 23 percent of boys and 16 percent of girls are obese by 15 months of age, according to a new study.

As some Pacific island cultures have “westernized” over the last several decades, among the changes has been a dramatic increase in obesity. Researchers don’t understand all the reasons why, but even a decade ago in American Samoa 59 percent of men and 71 percent of women were obese.

The new study’s findings may not be confined to Polynesian populations, but a harbinger of a slower-moving trend in the same direction in developed nations. Places like the mainland United States, after all, are the origin of the more sedentary, calorie-rich lifestyle that has largely replaced subsistence fishing and agriculture in American Samoa.

“One of the reasons we think Samoa is interesting is really because we think the level of obesity there could actually foreshadow what we see here in the United States and other high-income nations if we continue the way that we’re going,” says study lead author Nicola Hawley, a postdoctoral research fellow at Brown University and the Weight Control and Diabetes Research Center.

To conduct the study, published in the journal Pediatric Obesity, Hawley and her co-authors examined the medical records of nearly 800 American Samoan babies born between 2001 and 2008. The babies were all single births, carried to term of 37-42 weeks.

In particular, the team tracked the babies’ growth, weight gain, and whether they were breastfed, given formula, or a mix of both. They used the data to plot the trajectories of infant weight gain up to 15 months of age.

The researchers made several main findings:

One in five newborns qualified for a diagnosis of macrosomia—excessive birth weight of more than 8.8 pounds or 4 kilograms.

By 15 months of age 23.3 percent of boys and 16.7 percent of girls were obese (based on being heavier than the US Center for Disease Control’s 95th percentile). A further 16.1 percent of boys and 14.0 percent of girls were overweight.

At 15 months, 38.6 percent of formula-fed boys were obese while only 23.4 percent of breast-fed boys were obese.

Rapid gain

The babies were perhaps less heavy at birth than one might expect given the prevalence of obesity among their mothers, but the subsequent weight gain in early infancy was the study’s most important finding, says Stephen McGarvey, research professor of epidemiology and the study’s senior author. Rapid weight gain in infancy is widely understood to be a risk factor for adult obesity.

The median weight gain among the Samoan babies in the first four months of life was 978 grams a month, McGarvey says. That figure is almost 20 percent more than the 820 grams a month documented in a prior study of babies on the US mainland.

The Samoan babies’ average weight gain curve, he says, resembled the trajectory epidemiologists see among undernourished babies who suffer intrauterine growth restriction, meaning they are nutritionally deprived in the womb but then compensate by gaining weight rapidly after birth.

Samoan babies are not undernourished, McGarvey says, but they may also be somehow constrained in their growth as fetuses, perhaps because they are at an upper limit of growth before birth.

“We wonder whether this response is not partially a response to the events in utero,” says McGarvey. He and Hawley plan to pursue that question in future research.

“While the seemingly protective effect of breastfeeding has been shown in other studies, the results bolster the case for the idea that it extends to non-European populations. The finding also suggests a specific tactic—encouraging breastfeeding throughout more of infancy—that public health officials can employ in stemming infant obesity, at least in boys.

The researchers acknowledged that further research is required to understand why the benefits of breastfeeding were not seen in girls.

Most importantly, McGarvey and Hawley say, the study indicates that in a population with prevalent obesity such as in American Samoa, excessive weight begins in infancy.

Researchers from the University of Minnesota and the American Samoa Department of Health contributed to the study, which was funded by the National Institutes of Health and Brown University.