EXTENSIONS AND COMMENTARY: And that's all there is known as to the
activity of MMDA-3b in man. Very, very little. Nothing has ever been
tried in excess of 80 milligrams that I know of, and the above trials
were made over 20 years ago. There can be little argument that the 3b
is less effective than the 3a, but no one can say by how much. The
literature statement is that it is threefold less, but that was based
on the relative responses at just-above-threshold levels. The effects
here are hand-wavingly similar to those reported for MMDA-3a at 20
milligrams, but these are difficult to compare accurately as they were
reported by different people. There have been absolutely no animal
studies reported with MMDA-3b in the scientific literature. And
neither the 2-carbon nor the 4-carbon analogues of MMDA-3b has even
been prepared.

And if the information on MMDA-5 is sparse, look at the positional
isomer, MMDA-4, which I have discussed under its analogue TMA-4. Here
nothing is known at all, since the compound itself is unknown. No one
has yet found a way of making it.