T EbisawaDepartment of Biochemistry, The Cancer Institute of the Japanese Foundation for Cancer Research, and Research for the Future Program, the Japan Society for the Promotion of Science, 1 37 1 Kami Ikebukuro, Toshima ku, Tokyo 170 8455, JapanJ Biol Chem 276:12477-80. 2001

The N domain of Smad7 is essential for specific inhibition of transforming growth factor-beta signaling

A HanyuDepartment of Biochemistry, The Cancer Institute of the Japanese Foundation for Cancer Research, Tokyo 170-8455, JapanJ Cell Biol 155:1017-27. 2001

Roles of bone morphogenetic protein type I receptors and Smad proteins in osteoblast and chondroblast differentiation

M FujiiDepartment of Biochemistry, The Cancer Institute of the Japanese Foundation for Cancer Research and Research for the Future Program, Tokyo, JapanMol Biol Cell 10:3801-13. 1999

Interplay of signal mediators of decapentaplegic (Dpp): molecular characterization of mothers against dpp, Medea, and daughters against dpp

H InoueDepartment of Biochemistry, The Cancer Institute, Japanese Foundation for Cancer Research, and Research for the Future Program, Japan Society for the Promotion of Science, Tokyo 170 8455, JapanMol Biol Cell 9:2145-56. 1998

T EbisawaDepartment of Biochemistry, The Cancer Institute of the Japanese Foundation for Cancer Research, and Research for the Future Program, the Japan Society for the Promotion of Science, 1 37 1 Kami Ikebukuro, Toshima ku, Tokyo 170 8455, JapanJ Biol Chem 276:12477-80. 2001

..These results thus reveal a novel function of Smad7, i.e. induction of degradation of TbetaR-I through recruitment of an E3 ligase to the receptor...

The N domain of Smad7 is essential for specific inhibition of transforming growth factor-beta signaling

A HanyuDepartment of Biochemistry, The Cancer Institute of the Japanese Foundation for Cancer Research, Tokyo 170-8455, JapanJ Cell Biol 155:1017-27. 2001

..The N domain of Smad7 thus plays an important role in the specific inhibition of TGF-beta signaling...

Roles of bone morphogenetic protein type I receptors and Smad proteins in osteoblast and chondroblast differentiation

M FujiiDepartment of Biochemistry, The Cancer Institute of the Japanese Foundation for Cancer Research and Research for the Future Program, Tokyo, JapanMol Biol Cell 10:3801-13. 1999

..Through interaction with different transcription factors and transcriptional co-activators or co-repressors, Smads may exhibit specific effects in various cell types...

Ligand-dependent degradation of Smad3 by a ubiquitin ligase complex of ROC1 and associated proteins

M FukuchiDepartment of Biochemistry, The Cancer Institute of Japanese Foundation for Cancer Research, and Research for the Future Program, the Japan Society for the Promotion of Science, 1 37 1 Kami Ikebukuro, Toshima ku, Tokyo 170 8455, JapanMol Biol Cell 12:1431-43. 2001

..Smad3 bound to ROC1-SCF(Fbw1a) is then exported from the nucleus to the cytoplasm for proteasomal degradation. TGF-beta/Smad3 signaling is thus irreversibly terminated by the ubiquitin-proteasome pathway...

Interplay of signal mediators of decapentaplegic (Dpp): molecular characterization of mothers against dpp, Medea, and daughters against dpp

H InoueDepartment of Biochemistry, The Cancer Institute, Japanese Foundation for Cancer Research, and Research for the Future Program, Japan Society for the Promotion of Science, Tokyo 170 8455, JapanMol Biol Cell 9:2145-56. 1998

..We also show that Mad exists as a monomer in the absence of Tkv stimulation. Tkv induces homo-oligomerization of Mad, and Dad inhibits this step. Finally, we propose a model for Dpp signaling by Drosophila Smad proteins...

S AkiyoshiDepartment of Biochemistry, The Cancer Institute of Japanese Foundation for Cancer Research (JFCR, and Research for the Future Program, the Japan Society for the Promotion of Science, Toshima-ku, Tokyo 170-8455, JapanJpn J Cancer Res 92:257-68. 2001

..Taken together, the results suggest that TGF-beta may suppress tumorigenesis through positive and negative regulation of transcription...

..The evidence that Trx is a negative regulator of ASK1 suggests possible mechanisms for redox regulation of the apoptosis signal transduction pathway as well as the effects of antioxidants against cytokine- and stress-induced apoptosis...

..R-Smads interact with transcriptional coactivators, and have intrinsic transactivation activity. Elucidation of the functions of Smads will provide the framework for research on TGF-beta superfamily signaling...

T EbisawaDepartment of Biochemistry, The Cancer Institute of JFCR, and Research for the Future Program, Japan Society for the Promotion of Science, Toshima ku, Tokyo 170 8455, JapanJ Cell Sci 112:3519-27. 1999

..These findings indicate that in the process of differentiation to osteoblasts, BMP-6 binds to ALK-2 as well as other type I receptors, and transduces signals mainly through Smad5 and possibly through Smad1...

Interaction of Drosophila inhibitors of apoptosis with thick veins, a type I serine/threonine kinase receptor for decapentaplegic

Y KatsunoDepartment of Biochemistry, The Cancer Institute of the Japanese Foundation for Cancer Research, Koto ku, Tokyo, JapanOncogene 27:6322-33. 2008

..These results suggest that BMPs as well as TGF-beta promote invasion and bone metastasis of breast cancer...

Positive and negative regulation of TGF-beta signaling

K MiyazonoDepartment of Biochemistry, the Cancer Institute of the Japanese Foundation for Cancer Research JFCR, and Research for the Future Program, the Japan Society for the Promotion of Science, Toshima ku, Tokyo 170 8455, JapanJ Cell Sci 113:1101-9. 2000

..Regulation of TGF-beta signaling might be tightly linked to tumor progression, since TGF-beta is a potent growth inhibitor in most cell types...

..These results indicate that accelerated degradation of p57(Kip2) by TGF-beta1/Smad signaling is mediated through a newly synthesized factor(s) that modifies p57(Kip2) or the ubiquitin-proteasome pathway...

A role for Id in the regulation of TGF-beta-induced epithelial-mesenchymal transdifferentiation

..All together, the present results suggest that betaglycan ectodomain is endowed with two bona fide independent ligand binding domains that can perform specialized functions as co-receptors of distinct members of the TGF-beta superfamily...

..Taken together, our results suggest that the balance between the ALK1 and ALK5 signaling pathways in endothelial cells plays a crucial role in determining vascular endothelial properties during angiogenesis...

..These data indicate that CARP is a downstream target of TGF-beta/Smad signaling in VSMCs and suggest a role of CARP in mediation of the inhibitory effects of TGF-beta on the proliferation of VSMCs...

..5. Mutant cells showed significantly decreased responses to stimulation with activin and TGF-beta. These findings suggest that the two FYVE domain proteins, Hgs and SARA, are prerequisites for receptor-mediated activation of Smad2...

..The LTBP-2 gene was assigned to chromosome 14q24. These results indicate that different forms of latent TGF-beta complexes occur and suggest that the different associated proteins may function to target the complexes to specific sites...

Molecular cloning and characterization of ficolin, a multimeric protein with fibrinogen- and collagen-like domains

..These data suggest that TGF-beta induces heteromeric complexes of Smads 2, 3 and 4, and their concomitant translocation to the nucleus, which is required for efficient TGF-beta signal transduction...