The launch, which was broadcast live on NASA Television, was delayed twice this week, first by cold weather and then by high space radiation due to a massive solar flare on Tuesday. Both conditions could have affected critical rocket systems.

Orbital Sciences is one of two firms hired by the National Aeronautics and Space Administration to fly cargo to the station, a $100 billion project of 15 nations, following the retirement of the space shuttles in 2011.

Privately owned Space Exploration Technologies, or SpaceX, is preparing for its third supply run on February 22 from Cape Canaveral Air Force Station in Florida.

Thursday's launch was the third for Antares, a medium-lift rocket that Orbital Sciences also is marketing for satellite launches.

"We are negotiating with people with other payloads besides the Cygnus spacecraft and intend to fly more cargo out of Wallops," Culbertson told reporters before the launch. He declined to elaborate on prospective customers.

The company holds a $1.9 billion contract with NASA to fly eight Cygnus cargo ships to the station, a permanently staffed research outpost that flies about 250 miles above Earth.

SpaceX has a separate 12-flight NASA contract worth $1.6 billion.

Both companies expect to benefit from the Obama administration's decision on Wednesday to keep the station flying to at least 2024, a four-year extension.

Technically, the station is expected to remain structurally sound until at least 2028, according to a study by prime station contractor Boeing.

"It does give us a chance to think long-term, be innovative ... maybe invest in some improvements in how we can do this to make it more cost-effective and efficient," Culbertson said.

In addition to their station resupply contracts, Orbital Sciences and SpaceX previously received a combined $686 million from NASA to help develop their rockets, capsules and launch sites.

Orbital Sciences debuted its Antares rocket in April 2013 and made a successful test run to the space station five months later. It planned to start flying cargo in December, but NASA delayed the launch to tackle a high-priority repair to the station's cooling system.

Cygnus is loaded with 3,221 pounds (1461 kg) of equipment and supplies for the station, including science experiments, computers and replacement parts for NASA's spacesuits.

The capsule also holds food, fresh fruit and belated Christmas gifts for the crew. "We haven't changed them out for Valentine's cards," Culbertson quipped.

The freighter is due to arrive at the station shortly after 6 a.m. EST/1100 GMT on Sunday.