Building Blocks / Fragments

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Asinex Building Blocks

26789 Compounds
Update: 2019-02

ASINEX’s building block encompasses the legacy of our synthetic know-how and 20+ years of medicinal chemistry expertise with an ultimate goal of delivering novel, valuable chemical monomers for increasingly challenging drug discovery programs.
In addition to commonly popular functionalities, ASINEX building blocks represent the diversity of other valuable functional groups including alkenes, epoxides, amino alcohols and polyfunctional entities, which are especially useful for template-based generation of compound libraries where a polyfunctional building block can serve as a core scaffolding structure.
ASINEX Building Blocks have been validated for both chemical stability and reactivity. Many of these building blocks have been utilized for the synthesis of our natural product-like and macrocyclic libraries as well as for advancing a number of hit-to-lead optimization projects.

Asinex Fragments

22821 Compounds
Update: 2019-02

ASINEX has two approaches for fragments.
The first approach encompasses tremendous diversity of our scaffold and synthetic handles that allows straightforward progress from fragments to leads. The subsets of fragments suitable for specific biochemical and/or biophysical screening methods are available upon request.
The second “BioDesign” approach incorporates key structural features of known pharmacologically relevant natural products (e.g. alkaloids and other secondary metabolites) into synthetically feasible medicinal chemistry scaffolds. In order to identify the privileged pharmacophores, ring systems and linkers, we have carried out statistical analysis of structural features of natural products, marketed drugs, and drug candidates. Our research shows that saturated fused ring, spiro, bridged systems and macrocycles with a tendency towards multiple chiral centers are highly privileged among natural products and marketed drugs yet these structures are very poorly represented in commercial libraries. We deliberately introduced these highly privileged elements in the design of novel fragments with a higher level of saturation, multiple chiral centers and a high diversity of natural product-like frameworks.

Asinex Building Blocks
For DNA-encoded libraries

1738 Compounds
Update: 2018-12

At Asinex we have created several hundred bi- and tri-functional low MW monomers providing flexibility in DNA tagging chemistry and allowing further opportunity for molecule growth and linking. Most of the building blocks are uniquely available from Asinex, reflecting our multi-year investment into the design and synthesis of novel nature product-like compounds. For more information, please download >>>