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"protect is neatly-located to understand huge good points from exit transactions in 2016 due to continued profits growth and milestone achievements amongst our partner corporations," observed Stephen T. Zarrilli, President and CEO at safeguard. "preserve has grown its roster of healthcare and expertise associate agencies to 29. We consider that this growth will cause extra consistent exit exercise. When mixed with our disciplined approach to deployments and exits, we stay assured that look after can recognise aggregate cash-on-money returns at our goal of 2x."

2015 monetary Highlights

Realized $9.1 million and $7.eight million in cash proceeds from the revenue of protect's interests in companion organizations DriveFactor and Quantia, respectively. Milestone and escrow payments received all over 2015 involving outdated years' exits were $2.9 million for Crescendo Bioscience, $1.7 million for Alverix, and $three.3 million for ThingWorx.

Deployed $51.6 million of capital in eight new companion businesses all through the year, expanding the roster of accomplice organizations to 29 at yr-end. This total comprises fourth quarter deployments of $eleven.0 million as a part of a $20.0 million sequence B financing for Cask information, and $7.0 million as part of a $17.0 million series A financing for Zipnosis.

Deployed $33.3 million in observe-on funding all over the year to guide growth of 12 present partner businesses.

Repurchased $5.0 million of general stock in open market transactions beneath an ongoing $25 million share repurchase software licensed within the third quarter. via December 31, 2015, about 300,000 shares had been repurchased. about $3.3 million of the shares were repurchased all over the fourth quarter.

For the three months ended December 31, 2015, guard's internet loss changed into $14.3 million, or $0.69 per share, compared with a internet lack of $15.1 million, or $0.seventy three per share, for the same quarter of 2014. For the 12 months ended December 31, 2015, safeguard's net loss was $59.5 million, or $2.85 per share, compared with a net lack of $5.1 million, or $0.25 per share in 2014.

select associate company HIGHLIGHTS

big accomplishments through shield's companion corporations right through 2015 include:

CloudMine accelerated its depth into safety and compliance. The business accomplished assistance security program compliance in ISO 27001:2013 and eu/CH protected Harbor, plus extra invested in current HIPAA HITECH controls.

grasp Holdings deployed an array of technology enhancements to its customer-advertising and marketing platform, including a complete built-in e-mail carrier issuer system and an superior consumer-scoring dimension, amongst its current analytics portal.

Full Measure training launched its pupil-facing cell application to its first establishment. The cellular app is now obtainable in the App store and Google Play save.

decent delivery Genetics launched EmbryVuâ¢, a new reduce-cost pre-implantation genetic screening test that improves the chances of a success in vitro fertilization ("IVF") with the aid of determining embryos that have an multiplied opportunity of implantation and a success being pregnant.

Hoopla launched the subsequent-technology of Hoopla tv, a visible communication platform that empowers companies to boost a performance-driven culture.

MediaMath launched Helixâ¢, a brand new business unit providing big-scale, proprietary records sets to shoppers to pressure promoting and advertising choices. Helix is now accessible to U.S. customers and should be rolled out globally by means of place in 2016.

Medivo launched its OPALâ¢ De-Identification solution, which allows for monitoring of sufferers over time on an nameless basis, and is used through accomplice labs because the first step in lab records commercialization.Â

Propeller health got clearance from the U.S. food and Drug Administration ("FDA") to market its equipment to be used with bronchial asthma and persistent obstructive pulmonary sickness medicinal drugs administered through GlaxoSmithKline's Diskus dry powder inhaler, and with the RESPIMAT gentle mist inhaler from Boehringer Ingelheim.

Putney obtained FDA approval for three new usual veterinary products, expanding its product portfolio to 11.

QuanticMind launched over one hundred enhancements to its platform across the optimization, reporting, dashboarding and forecasting engines. QuanticMind Search brought new capabilities for key phrase expansion, Bing advertisements better Campaigns and Yahoo! Gemini integration. QuanticMind Social developed facebook monitoring, reporting and analytics capabilities to allow entrepreneurs to compare search and social performance in a single interface.

Syapse extended the scope of its core items to supply physicians with an automatic device to healthy patients to proper medical trials, and for clinical trial directors to establish eligible patients at their establishment. This functionality offers new options for sufferers for whom authorized remedies have failed, and an impressive useful resource for clinical trial administrators to boost enrollment.

Transactis launched its new digital responsive design know-how.

Trice clinical launched the newest edition of its product known as mi-eye+ which has been well acquired via the orthopedic surgeon group with its stronger visualization.

QuanticMind doubled the variety of subscribing purchasers 12 months-over-12 months, including tremendous-scale advertisers spending greater than $10 million a yr on search engine advertising and marketing, and persevered its international growth. New clients consist of Dafiti, Decathlon, Horizon Media, Ogilvy, Pet Circle, a leading fiscal functions enterprise within the online brokerage house, the greatest automotive retailer within the U.S., and the interactive division of a huge-three television community. a lot of these purchasers replaced first-generation software from Marin utility, Kenshoo, and Adobe.

Spongecell multiplied its relationship with Coles, considered one of Australia's largest retailers. The Australian grocery giant is the usage of Spongecell's programmatic inventive platform to personalize weekly advertisements with presents in accordance with the buying preferences of its loyalty club individuals. other extremely good client wins encompass American categorical, familiar Motors, and McDonald's.

Syapse received new contracts in principal health facility techniques and in country wide oncology networks together with Sarah Cannon, to launch a precision oncology medical provider line; providence health system, to empower Swedish melanoma Institute's personalized medication software; the American Society of clinical Oncology, to automate medical workflows for a nationwide clinical trial; and cancer middle cures of the usa, to enable medical workflows for its 5 regional facilities.

Transactis introduced long-time period contracts with 4 more of the biggest economic associations in North the united states and now serves 12 of the proper 50 U.S. banks.

Trice medical received several leading orthopedic health gadget accounts because the launch of mi-eye+ together with Geisinger fitness equipment, Rothman Institute, Mount Sinai medical institution, hospital for special surgical procedure, Lourdes health equipment, and Ortho Texas. Geisinger health equipment currently carried out its a centesimal mi-eye examination.

WebLinc launched an e-commerce website for brand new customer Stila Cosmetics and relaunched e-commerce websites for latest clients including FAM brands LLC manufacturers Marika and Zobha, as neatly as the Sak brand community brands The Sak, Sakroots, and Elliot Lucca.

~ Strategic Partnerships ~

Apprenda shaped a powerful company and technical partnership with Cisco, working to construct integrations at the side of Cisco's Metapod and ACI product offerings, and culminating in a recently introduced global reseller agreement. Apprenda also joined the newly shaped Cloud Native Computing groundwork, and the Open Container Initiative to aid ebook the trade requisites for container and microservices based software construction and operations.

Aventura partnered with BIO-key foreign to present a biometric-authentication solution for electronic prescription of managed substances.

past introduced a partnership with Udemy to increase the quality of job applicants by way of combining past's career development equipment with Udemy's knowledge-primarily based classes and with TextRecruit to permit textual content engagement.

CloudMine partnered with Xamarin, a number one tool for building cross-platform cell apps the use of C# & Java, and released C# entrance-end libraries to be able to aid Microsoft (.net) developers. furthermore, CloudMine dependent a strategic partnership with Alpha anywhere to give safety and compliance all the way through the expertise stack, while empowering IT and business clients to greater quickly bring cellular optimized kinds, enterprise-grade cellular apps and prosperous HTML5 web purposes, the use of a low-code strategy.

seize Holdings and take care of partner business, WebLinc, introduced a partnership that offers WebLinc's customers access to grab's advanced consumer loyalty and gift courses. clutch also entered right into a strategic partnership with POS on Cloud to deliver cloud-primarily based restaurant and retail reward card, loyalty, and client intelligence for agencies, and with EVO Platinum services community for advanced small and midsize company solutions to merchants.

respectable delivery Genetics partnered with Johns Hopkins school for noninvasive prenatal trying out; dependent a countrywide relationship with UnitedHealthcare; and is collaborating with Helix to increase reasonably-priced buyer functions that assist couples take note their reproductive health.

Lumesis completed a few a success partnership agreements all over the 12 months including AIREX Market, Bitvore, build america Mutual, Ipreo and Pershing.

MediaMath developed and continued to construct upon key advertising expertise partnerships with 33Across, Adform, Adyoulike, Dailymotion, Digital Analytics, Globo, IBM (as a part of the IBM common behavior trade), quintessential advert Science, engage, Navegg, Oracle, PubMatic, Teads, Tealeaf, Time Inc., and xtify. in addition, MediaMath announced strategic partnerships with each Oracle and IBM to help their clients power engagement through entry to the complete marketing stack including offline and electronic mail.

Pneuron partnered with HP to give valued clientele the capability to right now recognize value derived from new large information insights with less charge and greater agility; with UST global to extend market share and leverage related items and functions; and with NIIT applied sciences to raise device construction and company processing for organizations.

Propeller fitness reached a construction settlement with GlaxoSmithKline to improve a digital sensor for the Ellipta [Â®] inhaler; and improved its collaboration with the metropolis of Louisville, Kentucky, launching the Air Louisville public-private collaboration to collect records from sensors connected to 2,000 asthma inhalers.

Putneyannounced that Victor clinical enterprise, the largest privately owned veterinary distributor, will now distribute Putney's complete line of FDA-accredited veterinary popular products. Putney expects its partnership with Victor clinical to open new markets and pressure increased revenues, constructing on its recent string of checklist profits months.

Syapse announced strategic partnerships with important clinical methods and country wide oncology networks together with the tuition of California health equipment and the State of California, to make use of sequencing to diagnose patients who are hospitalized with infectious diseases; and Caris existence Sciences, to mixture molecular and genomic assistance with scientific medicine and results facts for its centers of Excellence network, establishing superior requisites of look after molecular tumor profiling in oncology.

Transactis partnered with average Register to enrich and simplify B2C and B2B money owed receivable procedures for shoppers and with Mutual of Omaha bank.

AppFirst was named a 2015 CODIE Award finalist by using the utility & tips business association.

Apprenda changed into named by using Forbes some of the right-three most useful enterprise cloud computing startups to work for in response to information from Glassdoor.

Aventura become named a good-one hundred technology startup enterprise through pink Herring.

CloudMine become awarded the 2015 Stratus Award in the "top of the line cell Infrastructure" category.

seize Holdings became honored, together with its client Meineke, with the 'customer adventure Award' from Loyalty360, the association of client Loyalty. seize became additionally honored as a robust Performer within the Forrester Waveâ¢: consumer Loyalty options For Midsize businesses document. clutch's CEO, Ned Moore, was named a finalist for the PACT enterprise 'technology CEO of the 12 months' award.

InfoBionic changed into noted as certainly one of seventy five girls-led startups in the Boston enviornment via BostInno.

MediaMath turned into named certainly one of Crain's 2015 surest places to Work and 50 quickest growing to be organizations; Glassdoor ranked Joe Zawadzki probably the most precise CEOs within the small and medium business category and the enterprise as the ideal Medium-Sized company to Work for, properly-20 service provider for Work-existence stability, and true-25 UK businesses for Compensation & advantages; M&M world named the company Programmatic company of the yr; and Gartner analysis named MediaMath a "Visionary" in its Magic Quadrant for Digital advertising and marketing Hubs. other awards encompass, but aren't restricted to, Deloitte expertise quick 500, Drum Digital's foremost know-how for Programmatic buying and selling, G2 Crowd's optimum score for DSP application, and Inc. 5000.

meQuilibrium was named a finalist on BostInno's 50 on fire that aspects Boston's greatest game changers.

Pneuron turned into named to the 2015 CRN [Â®] rising providers list for providing next-era expertise to raise enterprise intelligence and turned into named one in all 4 Cool companies in large statistics, 2015 by using Gartner.

Transactis become named to the 2015 AlwaysOn OnFinance accurate 100 checklist; named a cool dealer for 2015 through Gartner; and earned a properly a hundred North the united states award from purple Herring, along with rankings on the Inc. 500 and Deloitte expertise speedy 500.

~ Financings and other Milestones ~

Apprenda raised $38 million in funding to extra the adoption of its commercial enterprise PaaS.

Aventura raised a $14 million collection C financing to expand earnings and marketing, business development, and consumer support, in addition to speed up product construction.

Bridgevine mentioned an approximate forty% enhance in earnings, driven in part via the enterprise's entertaining cellular platform. more than 34 million households shopped via Bridgevine's digital commerce platform driving $1.9 billion in new earnings on behalf of the business's vast array of U.S. advertisers and partners.

Cask facts raised a $20 million sequence B financing to grow the enterprise's sales crew and extend its platform.

CloudMine raised a $5 million series A financing to enhance its product offering, construct vital strategic alliances, and extend advertising and revenue capabilities. furthermore, the enterprise introduced endured boom in 2015. Annual earnings tripled and employee headcount more than doubled, using funding in product research and building, safety and compliance.

grab Holdings raised a $5 million series B-2 financing to accelerate revenue and marketing.

Full Measure schooling raised a $5.5 million sequence B financing to extend sales and marketing and to accelerate platform construction.

InfoBionic raised an $8 million series B-1 financing to assist building and commercialization of InfoBionic's second-era cardiac arrhythmia detection platform, MoMe [Â®] Kardia.

decent start Genetics endured to develop its science with numerous abstracts and presentations at important scientific and clinical conferences, and published each its variant database validation and value effectiveness reports, additional building out its good of peer-reviewed publications in clinical journals.

MediaMath bought Berlin-based Spree7, a digital media consulting and programmatic promoting firm concentrated on the German, Austrian and Swiss markets. The transaction enhances MediaMath's enlargement strategy within the European, middle japanese and African areas. additionally, MediaMath made a few strategic hires including Chief monetary Officer, Richard Schmaeling; Chief advertising Officer, Joanna O'Connell; customary tips, Peter Piazza; SVP, records Science, Prasad Chalasani; and SVP, Vertical strategy and apply, Abhijit Shome. MediaMath moved its company headquarters to four World exchange core in new york metropolis, marking a significant milestone for the business.

meQuilibrium raised a $9 million series B financing to develop the business's income and advertising and marketing efforts and for product building. furthermore, meQuilibrium delivered a $4 million credit facility with Comerica bank, a circulate made to strengthen meQuilibrium's monetary fitness. meQuilibrium doubled its workforce and strengthened its engineering, product and revenue teams.

Pneuron effectively achieved a $5 million collection B-1 funding to scale-up the enterprise.

QuanticMind raised $10.3 million for product building and to extend earnings and advertising.

Sonobi raised a $5.four million collection A financing to accelerate construction of its Jetstream know-how.

Zipnosis raised a $17 million sequence A financing to expand the company's revenue and advertising and marketing efforts and accelerate product building.

Aventura, Inc. (Denver, CO) Aventura is a leading provider of cognizance computing for the healthcare business. through its patented know-how, Aventura supplies cognizance of a person's id and function, the location within a facility, the gadget being used, and the patient being handled.

first rate birth Genetics, Inc. (Cambridge, MA) good birth Genetics is a business-stage molecular genetic advice business reworking the standard of care in reproductive medication and family medication with the aid of featuring physicians and their sufferers a collection of products that supply clinically valuable, insightful and actionable guidance in an effort to promote a success pregnancies and healthy families.

Medivo, Inc. (ny, ny) Medivo unlocks the power of clinical diagnostics to improve fitness. Medivo makes use of superior analytics and proprietary sickness algorithms to deliver entertaining focused on intelligence for all times science groups; commercial effectiveness opportunities for diagnostic corporations; and excellent development and chance administration options for payers. Medivo is the largest source of lab statistics in the U.S. with entry to over 150 million sufferers through its nationwide community of associate labs.

Putney, Inc. (Portland, ME) Putney is a pharmaceutical business dedicated to offering excessive fine, affordable typical drug treatments for pets. Putney's respectable supply of low-priced drug alternate options empowers veterinarians, enabling them to deliver the very best medication at the best possible cost, and supports pet owners, helping them find the money for to conform to veterinary thoughts.

Syapse, Inc. (Palo Alto, CA) Syapse drives healthcare transformation via precision medicine, enabling provider programs to enrich scientific outcomes, streamline operations, and shift to new charge fashions. Syapse Precision medication Platform is a complete application suite used by way of main fitness methods to guide the clinical implementation of precision drugs in oncology and different service traces, enabling scientific and genomic records integration, decision guide, care coordination, and nice growth at point of care.

AppFirst, Inc. (manhattan, ny) AppFirst's patented know-how enables rapid and unintrusive collection of true-time foundational metrics, at the sub-nanosecond level, along with collecting and time synchronizing diverse other records forms. AppFirst's wealthy data set can be used for many functions including protection introspection, unique forensics, regulatory compliance, actual time transaction tracing, real time topology viewing, operations management, efficiency administration, targeted charge monitoring, and a lot of other purposes for each cloud and proprietary environments.

Apprenda, Inc . (Troy, the big apple) Apprenda is a number one enterprise PaaS business powering the next generation of commercial enterprise utility building in public, private and hybrid clouds. As a foundational software layer and utility run-time atmosphere, Apprenda abstracts away the complexities of building and providing modern utility purposes, enabling firms to turn ideas into innovations extra rapidly.

past.com, Inc. (King of Prussia, PA) beyond.com ("past"), The profession communityâ¢, helps thousands and thousands of authorities find jobs and enhance their careers whereas additionally serving as the premier destination for companies in need of top talent. here is carried out via more than 500 skill communities that use built-in social features to help individuals discover central jobs, profession information, career suggestions and elements.

Bridgevine, Inc. (Atlanta, GA) Bridgevine is the domestic of customer acquisition. The company powers digital options the place product and repair give from the main brands meets purchaser and small/medium business demand. more than 2.eight million households per 30 days shop throughout the Bridgevine marketplace via a blend of direct advertising and marketing and proprietary distribution channels.

Cask information, Inc. (Palo Alto, CA) Cask accelerates the development and deployment of production Hadoop purposes. Hadoop is the business average open source software framework for enormous-scale facts applications.

CloudMine, Inc. (Philadelphia, PA) CloudMine's connected health Cloud integrates the mammoth world of fitness recordsâempowering payers, suppliers, and pharmaceutical groups to mobilize affected person suggestions by way of building amazing purposes and using actionable insights. via guide for laptop learning, information science, and predictive analytics, CloudMine purchasers are enhancing the excellent of care with the aid of leveraging cognitive facts evaluation to determine patient interactions.

Full Measure schooling, Inc. Â (Washington, DC) Full Measure education offers colleges and universities a value-advantageous SaaS pupil engagement platform to maximize student success. This gadget-large infrastructure raises pupil persistence, engagement and goal accomplishments, delivering guidance to students once they need it and how they've come to are expecting it.

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MediaMath, Inc. (long island, new york) MediaMath is a global technology business it's leading the circulation to revolutionize average advertising and marketing and pressure transformative effects for entrepreneurs via its TerminalOne advertising working gadget [Â®] . A pioneer within the trade, introducing the first Demand-side Platform with the business's founding in 2007, MediaMath is the best company of its type to empower entrepreneurs with an extensible, open platform to unleash the energy of aim-primarily based advertising at scale, transparently throughout the enterprise. Â

Pneuron corporation (Woburn, MA) Pneuron allows companies to abruptly resolve company problems via a groundbreaking, disbursed method that cuts across facts, applications and techniques. with the aid of concentrated on the appropriate counsel at the information source, businesses aren't any longer confronted with the complex integration and infrastructure necessities of ordinary strategies.

Spongecell, Inc. (manhattan, new york) Spongecell is a creative expertise company that allows company advertisers to create very own connections at a world scale. providing clever statistics integrations, subtle decisioning tools and a straightforward, streamlined workflow, Spongecell's artistic Optimization and Relevance Engine permits advertisers, and their creative groups, to make smarter creative selections and build on-line campaigns that resonate with consumers and reply to something the advertising want is.

Transactis, Inc. (ny, the big apple) Transactis is a number one issuer of digital billing and price options. Transactis' cloud-based mostly digital invoice presentment and price platform, BillerIQ, is a white-labeled solution that is obtainable "as-a-carrier," enabling groups to hastily and securely deliver electronic expenses, invoices and files as well as accept funds on-line, with the aid of phone and by the use of mobile gadget.

WebLinc, Inc. (Philadelphia, PA)WebLinc is a commerce platform provider for fast transforming into online marketers. WebLinc tailors its commerce platform to the wants and scale of mid to significant dealers by way of leveraging extensive journey and success assisting shoppers' want for speedy growth and device flexibility.

conference call AND WEBCAST details Please name 10-quarter-hour prior to the name to register.

Replay might be available via April three, 2016 at 11:59pm EDT. For more information please contactÂ IR@guard.com.Â

About shield Scientifics defend Scientifics, Inc. SFE, -0.eighty five% has a extraordinary music list of fostering innovation and constructing market leaders. For six many years, shield has been presenting increase capital and operational assist to entrepreneurs throughout an evolving spectrum of industries. nowadays, guard is concentrated primarily on two sectorsâhealthcare and technology. specifically, take care of objectives early- and increase-stage businesses in promoting know-how, digital media, monetary technology, business application, internet of things, devices, diagnostics, digital fitness and healthcare IT. For greater counsel, please seek advice fromÂ www.safeguard.comÂ or comply with us on Twitter @guard.

forward-looking Statements aside from the historical guidance and discussions contained herein, statements contained during this release might also constitute "forward-looking statements" in the meaning of the private Securities Litigation Reform Act of 1995. Our forward-looking statements are subject to risks and uncertainties. The hazards and uncertainties that might cause exact results to vary materially consist of, among others, our means to make good decisions concerning the deployment of capital, the fact that our accomplice companies might also fluctuate from duration to period, our mammoth capital necessities and absence of liquidity from our associate enterprise holdings, fluctuations in the market fees of our publicly traded accomplice business holdings, competitors, our lack of ability to attain highest price for our associate enterprise holdings, our capability to attract and maintain certified employees, market valuations in sectors wherein our associate companies function, our inability to manage our companion corporations, our deserve to manage our property to stay away from registration beneath the investment business Act of 1940, and hazards linked to our accomplice organizations, including the incontrovertible fact that most of our partner companies have a limited heritage and a heritage of working losses, face excessive competition and might by no means be profitable, the impact of economic circumstances within the business sectors wherein shelter's companion corporations function, and different uncertainties described in our filings with the Securities and alternate commission. many of these elements are past the company's capability to foretell or manage. because of these and other elements, the enterprise's previous economic performance should still now not be relied on as an indication of future efficiency. The enterprise does not count on any duty to update any forward-looking statements or different suggestions contained during this press release.

safeguard CONTACTS: For Investor members of the family John E. Shave IIISenior vp, Investor relations and company Communications 610.975.4952 jshave(at)take care of(dot)com

For Media family members Heather R. Hunter vice chairman, company Communications 610.975.4923 hhunter(at)safeguard(dot)com

To help traders in knowing defend and our 29 partner corporations as of December 31, 2015, we're providing further financial tips on our accomplice agencies, together with the aggregate cost and carrying value for all of our associate businesses and different holdings.Â Carrying cost of an equity formulation accomplice company represents the long-established acquisition charge and any follow-on funding, plus or minus our share of the income or losses of each and every company, reduced by means of any impairment expenses.Â The carrying value and price information reflect our percentage holdings in the partner corporations and reflect both equity ownership hobbies in and advances to these partner companies.

December 31, 2015

Carrying cost

charge

shield Carrying price and cost

fairness formula accomplice groups

$

162,919

$

291,375

charge method companion businesses

four,574

10,035

other holdings

four,108

36,711

$

171,601

$

338,121

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supply protect Scientifics, Inc.

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