Euro Personalized Medicine 2018

Welcome Note

Dear Colleagues, Scientists and Friends,

On behalf of the Organizing Committee, we would extend a warm welcome to all of the distinguished speakers and participants of the 8TH EUROPEAN CONFERENCE ON PREDICTIVE, PREVENTIVE & PERSONALIZED MEDICINE (PPPM) AND MOLECULAR DIAGNOSTICS which is to be held during August 20-21, 2018 in the Great and Ancient Rome to illustrate the Academic Capital of Country and the Cultural Capital of the Globe. Building on the success of the preceding meetings, the Conference will feature a highly interactive, stimulating and multidisciplinary program including initiatives to address the entire patient-physician pathway and to look beyond the scientific topics alone.

PPPM as the Medicine of the Future is a new philosophy and new culture that should be promoted early in life with all tools and programs available. Today PPPM is becoming the strategic mainstream of medical science and research, and significantly influences the future of the care based on the evidence-based and translational medical research, the needs and the challenges in daily medicine, the healthcare services networks, and the strategies of biopharma and healthcare industry as well.

In this context, our universities were among the first academic institutions in Europe who had laid a first and still virgin brick into the foundation of a novel medical strategy whilst setting up two brilliant stones, i.e., Center for Personalized Medicine and Department for Translational Medicine. And the Director and Faculty Chair of above-mentioned, respectively, and thus being the Russian Ambassador, let me discuss issues of possible mutual interest with medical professionals, researchers, clinicians and healthcare specialists who have been tackling the advancing innovations of PPPM.

PPPM and its armamentarium are becoming the strategic mainstream of biomedical science and healthcare services, and significantly influences the future of the personalized healthcare based on the evidence-based and translational medical research. You will be able to share experiences and research results, discuss challenges encountered and solutions adopted and have opportunities to establish productive new academic and industry research collaborations. The Conference provides a unique opportunity for university leaders, educators, clinicians, bioengineers, experts and scholars of higher education from all over the world to convene and share novel ideas on crucial issues and trends in the area of regenerative medicine. The Conference will thus provide enough space for discussion, meetings and workshops in order to allow a close contact between speakers and visitors.

At Sechenov Medical University, Moscow Engineering Physical Institute (MEPhI), National Alliance of Translational Medicine (NATM) and United Cultural Convention (Cambridge, UK) we look forward to welcoming you to Conference, to be held in one of the well-known, prestigious, historic and unique City, Rome, to taste a smell of the deeply rooted science and culture.

We do hope that you will enjoy the Conference and that your interaction with your colleagues from many different countries will stimulate a creative exchange of ideas and will be personally rewarding!

About Conference

Euro Personalized Medicine 2018 Conference welcomes the Professors, Pathologists, Specialists, Clinical Geneticist, Cytogenetic Diagnostics, Therapists, Researchers Specialized from Molecular Genetics and Genomics, Physicians and Hospitalists with different specialties such as Endocrinologist, Cardiologist, Nephrologist, Orthopaedic, Haematologists, Immunologists, Oncologists, Rheumatologist, Research scholars, Industrial professionals and Student delegates from Biomedical, Pharmaceuticals and Telemedicine and Healthcare Sectors to be a part of it, from all over the world to Rome Italy . We are delighted to invite you all to attend and register at “ 8th European Conference on Predictive Preventive and Personalized Medicine & Molecular Diagnostics " which is going to be held during August 20-21, 2018, in Rome, Italy.

The theme of the conference is “Unleashing the novel approaches in advancing Personalized Medicine”.Euro Personalized Medicine is a multidisciplinary field, interesting and interactive scientific sessions have been designed accordingly for this conference which includes the diagnosis, care and management of different acute and chronic medical conditions, comprises of various medical specialties such as cardiac health issues, brain disorders, digestive diseases, blood disorders, respiratory diseases, different types of cancers , immunological and infectious diseases, basically all minor and major health issues which requires short and long-term, comprehensive care.

The organizing committee is gearing up for an exciting and informative conference program including plenary lectures, symposia, workshops on a variety of topics, poster presentations and various programs for participants from all over the world. We invite you to join us at the Euro Personalized Medicine -2018, where you will be sure to have a meaningful experience with scholars from around the world. All members of the Euro Personalized Medicine-2018 organizing committee look forward to meeting you in Euro Personalized Medicine -2018.

Conference Series Ltd has an enhanced and highlighted features of scientific partnerships and alliances with development agencies, Institutes, leading research organizations, non-government organizations, and other entities to promote the development-oriented research across the globe through live streaming, B2B and Scientific Meetings. Conference Series Ltd’s Medical Conferences provides an excellent opportunity for the budding scientists and young researchers through its special initiatives like Young Researcher Forum, Poster Presentation and E-poster. Conference Series Ltd Organizes 300+ Scientific Conferences every year across USA, Europe & Asia. Besides 500 Peer reviewed, Open Access Journals, Conference Series Ltd has collaborated with more than 1000 Scientific Associations and institutions worldwide to promote information on health care and technologies. These journals are enjoying the support of over 5 million readers; a team of 30.000 eminent scholars is providing editorial support.

Importance and scope: It estimated that 57 countries have an absolute shortage of 2.3 million physicians and nurses, midwives. This shortage of primary health care professionals suggests that many countries have insufficient numbers of health professionals to deliver essential health interventions. The shortage is defined as having a projected supply of primary physicians that meet less than 80% of the forecasted primary care demand or need, calculated at estimated means.

Professors and students from academia who are in the field of research, Medical and clinical research, Professors, Pathologists, Specialists, Clinical Geneticist, Cytogenetic Diagnostics, Therapists, Researchers Specialized from Molecular Genetics and Genomics

Preventive healthcare consists of measures taken for disease prevention, as opposed to disease treatment. A medicine or other treatment designed to prevent disease or ill healths. Which is affected by environmental factors, genetic predisposition, disease agents, and lifestyle choices

Molecular diagnostics method used to analyze biological markers in the genome and proteome and by applying molecular biology to medical testing. This technique is used to diagnose and monitor disease, detect risk, and decide which therapies will work best for individual patients.

Personalized medicine is a medical practice that separates patients into different groups with medical decisions, practices, interventions, and products being tailored to the individual patient based on their predicted response and risk of disease.

Personalized Medicine alludes as an individualized treatment which implies the solution of particular medications and therapeutics. Personalized Medicine 2018 highlights the topic "Exploring Innovations in advancing Personalized Medicine and Bio-Markers"alongside the logical system clears an approach to assembling visionaries through the exploration talks and presentations. A definitive mission of the meeting is to advance numerous interesting the Novel Approaches and Innovations in customized prescription and social insurance, serves a motivation for the progression of Molecular Diagnostics, a brief talk on Protein Biomarkers, extraordinary spotlight on Genetics Informed Personalized Immunotherapy and Stem Cells Therapy as the Future of Personalized Medicine. Customized Medicine guarantees numerous restorative advancements, and can possibly change the way medications are found and utilized.

Conference Series Ltd is devotedly involved in conducting 300+ Conference Series Ltd Every Year across Europe, USA (Baltimore, Chicago, Las Vegas, Philadelphia, and San Antonio) and almost all other parts of the world with support from 1000 more scientific societies and Publishes 400+ Open access journals which contains over 30000 eminent personalities, reputed scientists as editorial board members.

Personalized medicine therapeutics and companion diagnostic market have huge opportunities for growth in healthcare and will improve therapeutic effectiveness and reduce the severity of adverse effects approach to drug therapies. Personalized cancer medicine is self-made samples of translating cancer genetics into medical. There is a huge contribution of Genomic medicine by revealing genomic variations; have an effect on health, sickness and drug response. Biomarker also plays vital role in the biological characteristic which can be molecular, anatomic, physiologic and chemical change drug development research which turns biomarkers into companion diagnostics.

Benefits of Attending the Conference

The Career Guidance Workshops to the Graduates, Doctorates and Post-Doctoral Fellows, Certificate Accreditation from the Organizing Committee of presentation/ participation.

Accepted Abstracts will be published in the respective journals and will be labeled with a Digital Object Identification Number (DOI) provided by Cross Ref (Free abstract publishing).

Speaker and Abstract pages created in Google on your name would get worldwide acknowledgment to your profile and Research.

Sessions and Tracks

The 8th European Conference on Predictive Preventive and Personalized Medicine & Molecular Diagnostics will be held on August 20-21, 2018 in Rome, Italy will be organized around the theme “Exploring Innovations in advancing Personalized Medicine and Bio-Markers” which comprises 23 Sessions/Tracks to outline the theme of the conference organized by conference series llc LTD Conferences. The main aim of the conference is to highlight the achievements and innovations in the various fields of Personalized Medicine across the globe.

In personalized medicine molecular diagnostics is used for analysing of biological markers and also analysing by applying molecular biology to medical testing .This technique is used to diagnose and monitor disease, detect risk in individual patients .DNA sequencing is the process of determining the precise order of nucleotides within a DNA molecule .SNP genotyping is the measurement of genetic variations of single nucleotide polymorphism (SNPs).which is the measurement of more general genetic variation. Gene expression profiling is used for the measurement of the activity of thousands of genes at once.

In personalized medicine biomarkers and biological marker generally refers to a measurable indicator of some biological state or condition. This word refers to a substance the presence of which indicates the existence of a living organism. Biochemical biomarkers are often used in clinical trials, Biomarkers used for personalized medicine are typically categorized as either prognostic or predictive .In, a biomarkers is a molecule that allows the detection and isolation of a particular cell type. A biomarker indicates a change in state of a protein that correlates with the risk or progression of a disease . Biomarkers are useful in a number of ways, including measuring the progress of disease. Biomarkers also used in early diagnosis, disease prevention, drug target identification, drug response etc.

In personalized medicine pharmacogenetics is the study of inherited genetic differences in drug metabolic pathways which can affect the drug responses, like therapeutic effect as well as adverse effect. Inter- and intra-individual variation in gene expression and its function.In oncology, pharmacogenetics refers to germline mutations and pharmacogenomics is study the somatic mutations in tumoral DNA leading to alteration in drug response

Pharmacogenomics is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response, drug absorption distribution, metabolism, and elimination ,as well as drug receptor target effects . Pharmacogenomics is often used interchangeably with pharmacogenetics. Pharmacogenomics is used for the detection of the individual genetic variation with drug responses pharmacogenetics focuses on single drug-gene interactions, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response

The proteome is the entire set of proteins it is expressed by genome , cell, tissue, or organism at a certain time. More specifically, it is a combined of proteins and genomes . Proteomics is the study of the proteome. A cellular proteome is the collection of proteins present in a particular cell type and it exposure to harmone stimulation . It can also be useful to consider an organisms complete proteome, which can be conceptualized as the complete set of proteins from all of the various cellular proteomes. Proteome used to refer to the collection of proteins in certain sub-cellular biological systems.

Metabolomics is defined as the chemical processes involving of metabolites. Metabolomics is the study of the unique chemical fingerprints. The metabolome refers to the collection of all metabolites in a biological cell, tissue, organ or organism. mRNA gene expression data and proteomic analyses reveals the set of gene products in the cell. One of the challenges of system biology and functional genomics is to integrate proteomic ,transcriptomic, and metabolomic information to provide a cellular biology.

Personalized medicine is a Medical Practice that separates patients into different groups with medical decisions, practices, interventions and products being tailored to the individual patient based on their predicted response or risk of disease. The words of personalized medicine, precision medicine, stratified medicine and P4 medicine are used interchangeably .

Epigenomics is a set of epigenetic modifications on the genetic material of a cell is called as the epigenome. Epigenetics are reversible modifications on a cells DNA that affect the gene expression without altering the DNA sequence. Epigenetic modifications are important role in the gene expression and regulation, that are involved in the numerous cellular processes such as tumorigenesis.

Biological therapy refers to the use of medication , specifically target an immune or genetic mediator of disease. Even for diseases of unknown cause of molecules that are involved in the disease process have been identified, and can be targeted for biological therapy. which are mainly cytokines , are directly involved in the immune system .Biological therapy used for the management of cancer , autoimmune disease, and diseases of unknown cause that result in symptoms due to immune related mechanisms.

Cancer is cured by surgery ,chemotherapy , radiation therapy , hormonal therapy and targeted therapy including immuno therapy such as monoclonal antibody therapy. The choice of therapy depends upon the location ,tumor and stage of disease as well as the general state of the patient

Infection is invasion of an organisms , body tissues by disease causing agents their multiplication and the reaction of host tissues to these organisms and they produced toxins . Infectious disease also known as transmissible disease and communicable disease, is illness resulting from an infection.

A neurological disorder is any disorder r of the body nervous system. Structural, biochemical or electrical abnormalities of brain, spinal cord or other nerves can result in a range of symptoms. The symptoms include paralysis, muscle weakness , loss of sensation,seizures confusion pain and altered levels of consciousness.They may be assessed by neurological examination, studied and treated within the specialities of nuerology and clinical neuropsychology

Mental disorders are psychological condition primarily by sufficient disorganization of personality, mind, emotions to seriously impair the normal psychological condition. Mental disorders occasionally consist a combination of affective behavioural cognitive perceptual components. The acknowledgement of mental health conditions has changed over time and across cultures, and still observed variations in the definition,classification,and treatment of mental disorders.

Cardiovascular disorders is require an organized interpretation of variations in DNA and mRNA as well as proteins. The advance biotechnology is being applied to improve the diagnosis and treatment of cardiovascular disorders. A five-step strategy can be followed to identify genes and gene products involved in differential responses to cardiovascular drugs .

Chronic obstructive pulmonarydisease is a type of obstructive lung disease characterized. The main symptoms includes a breath and cough with suptum production.COPD typically worsens over time . Eventually walking up stairs or carrying things will be difficult. Tobacco smoking is the most common with a number of other factors such as air pollution and genetics.

Genetic disorders may or may not be heritable from the parents genes. In non-heritable genetic disorders, defects may be caused by new mutations and changes to the DNA. In such cases, the defect will only be heritable if it occurs in the germ line .Such as some forms of cancer, may be caused by an inherited genetic condition in some people by new mutations in other people, and mainly by environmental causes in other people. Whether, when and to what extent a person with the genetic defect abnormality will actually suffer from the disease is almost always affected by the environmental factors and events in the persons development.

Autoimmune diseases is damage a pathologic state arising from an abnormal immune response of the body against substances and tissues are normally present in the body. Autoimmunity is the presence of self-reactive immune response. (e.g., auto-antibodies and self-reactive T-cells) with or without damage or pathology resulting from it.

Personalized medicine is a Medical Practice that separates patients into different groups with medical decisions, practices, interventions and products being tailored to the individual patient based on their predicted response or risk of disease. The words of personalized medicine, precision medicine, stratified medicine and P4 medicine are used interchangeably

The FDA is already started to take initiatives to integrate personalized medicine into their regulatory policies.They developed a report in October 2013 entitled Paving the Way for Personalized Medicine FDAs role in a New Era of Medical Product Development in which they outlined steps they would have to take to integrate genetic and biomarker information for clinical use and drug development. They determined that they would have to develop specific regulatory science standards, research methods, reference material and other tools in order to incorporate personalized medicine into their current regulatory practices. For example, they are working on a genomic reference library for regulatory agencies to compare and test the validity of different sequencing platforms in an effort to uphold reliability.

Health economics is a study of economics concerned with issues related to efficiency, effectiveness, value , behavior in the consumption of healthcare. In broad terms health economists study the functioning of healthcare systems and health-affecting behaviors such as smoking.Health economists evaluate multiple types of financial information costs, charges and expenditures.

Medical ethics is a system of moral principles that apply values and judgments to medical practice. As a scholarly discipline, medical ethics encompasse its application in clinical settings as well as work on its history, philosophy, and sociology.

Personalized medicine is a Medical Practice that separates patients into different groups with medical decisions, practices, interventions and products being tailored to the individual patient based on their predicted response or risk of disease. The words of personalized medicine, precision medicine, stratified medicine and P4 medicine are used interchangeably

Personalized medicine is a Medical Practice that separates patients into different groups with medical decisions, practices, interventions and products being tailored to the individual patient based on their predicted response or risk of disease. The words of personalized medicine, precision medicine, stratified medicine and P4 medicine are used interchangeably .

Market Analysis

Market Analysis:

Scope and importance:

8th International Conference on Predictive, Preventive & Personalized Medicine and Molecular Diagnostics contributes the opportunities to determine advance techniques used in Diagnostics labs, Genetics, Biology labs and which basically deals with the latest research and developments in the sphere of genetics and molecular biology. This Conference will provide a perfect platform to all the International mix of leading Research Scholars, and Scientists achieved eminence in their field of study, research academicians from the universities and research institutions, industrial research professionals and business associates along with Ph.D. Students to come and inform all the attendees about the latest scientific advancements on the respective sphere.

8th International Conference on Predictive, Preventive & Personalized Medicine and Molecular Diagnostics is a perfect platform for Expanding the innovative techniques and novel research trends in clinical genetics. Clinical research is a versatile conference that offers expert diagnosis, treatment all types of disorders in genetics and Drug therapies, Biological therapies. With the Annual meeting on Geneticist’s, Cyto-pathologists, Pathologist, Clinical research, case reports we will expect the expert gathering from Universe so that novel idea or novel research will come with a discussion at the conference and that will be fruitful to children adversity from different types of diseases. This International Personalized Medicine Conference additionally supports the dynamic cooperation of youthful understudy analysts as we are facilitating Poster Award Competition and Young research Forum at the meeting setting.

Market research:

The global personalized medicine in market was valued at USD 1,007.88 billion in 2014 and is expected to reach USD 2,452.50 billion in 2022, growing at a CAGR of 11.8% over the forecast period. Key drivers of the market include growing development of next generation sequencing, whole genome technology, companion diagnostics and growing number of retail clinics. Growing healthcare expenditure levels triggering the need for an effective diagnostic procedure for cancer, growing prevalence of cancer and increasing usage of combination biomarkers for diagnostics are few factors expected to boost market growth. Increasing adoption of next generation sequencing for genetic mapping of patients by clinicians and medical practitioners worldwide, and growing support for personalized medicine by reimbursement and regulatory landscape are also factors expected to drive demand through to 2022. Market growth is also expected to rise through the novel introduction of drugs with associated and companion diagnostics, and growing usage of highly sensitive, accurate genetic diagnostic techniques for disease testing and risk assessment. Anticipated increase advanced DNA diagnostic usage combined with the reduction in implementation costs for whole genome sequencing is expected to considerably increase penetration rates.

Advancements in the field of genomics have created ample opportunities for personalized medicines to emerge in the healthcare industry. Personalized medicine represents an interface of therapeutics and diagnostics. It involves the tailoring of treatments as per individuals. The growing research applications and identification of molecular markers towards disease predisposition and progression have led to the growth of personalized medicine. Industry players have also rapidly adopted this field and are progressing towards achieving higher goals in the same. According to our new research report, “Personalized Medicine Market Analysis”, the U.S. represents the brightest market for personalized medicine and is anticipated to grow at a CAGR of around 9.5% during 2012-2018. The need for rapid detection of diseases, especially cancer, and their more efficient treatments are primarily driving this market. Besides USA, countries like the U.K., France, Germany, India, China, and Japan have also been trying to pioneer personalized medicine with the help of advanced technologies. A lot of investment has been undergoing for research and development to develop biomarkers and personalized healthcare solutions in order to improve the medical outcomes. Our report provides a prudent analysis at the country level, elucidating the level of personalized medicine penetration, recent industry developments and the future growth prospects. Companies are actively involved in the development of advanced technological tools and diagnostic equipment’s that help in promoting personalized medicine. Strategic alliances and consolidation has also become a common trend towards greater market presence. Academic and private research institutions as well as small biotech and major pharmaceutical companies are increasingly looking for alternative ways to strengthen their pipelines. The report highlights the various strategies being adopted by market players and research institutes to promote growth in this field. The report also covers the industry positioning in terms of the major therapeutic areas. The study also provides an insight into the segment-wise competitive landscape, which includes the profiles of Pharmaceutical/Biotech, Diagnostic, IT/Informatics, and Research Tool companies across the globe. Through the report, companies planning to venture into the personalized medicine sector will also have an in-depth understanding of the industry dynamics.

Conference highlights:

Molecular Diagnostics in Personalized Medicine

Biomarkers in Personalized Medicine

Pharmacogenetics in Personalized Medicine

Pharmacogenomics in Personalized Medicine

Pharmacoproteomics in Personalized Medicine

Metabolomics Personalized Medicine

Personalized Biological Therapies

Personalized Therapy of Cancer

Treatment of Infectious Diseases

Treatment of neurological disorders

Treatment of Psychiatric Disorders

Treatment of Cardio vascular disorders

Treatment of Pulmonary Disorders

Treatment of Genetic Disorders

Treatment of immune disorders

Personalized in HealthCare

Developed of personalized medicine

Ethics of personalized medicine

Economics of personalized medicine

Regulatory of Personalized medicine

Future of Personalized medicine

Clinical Management in Personalized Medicine

Personalized Medicine in lung Cancer

Personalized Medicine in Oncology

Why to attend?

To meet people and organizations addressing these same key issues.

To meet people with whom you’ve established a relationship on social media.

To learn about job, internship, project and other work-based possibilities.

To learn about fellowship and grant opportunities relevant to your area(s) of interest.

To gain insight into the experiences of others who face challenges similar to yours.

To learn about publications and other resources relevant to your area(s) of interest.

Be Part of it!

This conference focusing on all the major aspects in the fields of Specialized from Molecular Genetics and Genomics, Pathologists, Specialists, Clinical Geneticist, Cytogenetic Diagnostics, Therapists, Researchers etc.

It would be beneficial for all the students who ever willing to enter into corporate worlds targeting to the respective fields

This Meeting strategic astuteness is to be an event for bringing together Scientists, Physicians, International mix of leading Universities, Diagnostics and Geneticists Institutions, Companies and Clinical to transform the practices to control and cure these genetic disorders etc.

Visa Information

We believe you must be having a query regarding your Visa to travel Italy. Here is the simplest way to know the process for your Visa Approval (Schengen Visa). Kindly drops us an email at [email protected]

Places to visit in Rome, Italy-

Colosseum

Trevi Fountain

Pantheon

Basilica di Santa Maria Maggiore

Roman Forum

Piazza Navona

Basilica Papale San Paolo Fuori le Mura

Villa Borghese

Quirinal Palace and many more…!!

Past Conference Report

Euro Personalized Medicine 2017

The 6th Conference on Predictive, Preventive and Personalized Medicine & Molecular Diagnostics, hosted by the Conference series LLC was held during September 14-15, 2017 at Edinburgh, Scotland with the theme “Unleashing the novel approaches in advancing Personalized Medicine". This one-stop meeting provided comprehensive updates, education, and information on current and emerging Personalized Medicine issues and challenges.

The Conference was accomplished by the support of personalized specialty world molecular biologists, diagnostic therapists, physicians, bio-informaticians, academic scientists, industry researchers, scholars, decision makers, public health professionals and other health care professionals representing more than 25 countries, who made this conference fruitful and productive.

We are also thankful to the following exhibitor for their participation and interactive sessions:

The Ondamed companies,

The meeting was carried out through various sessions, in which the discussions were held on the following major scientific tracks:

· Molecular Diagnostics in Personalized Medicine

· Biomarkers in Personalized Medicine

· Pharmacogenetics in Personalized Medicine

· Pharmacogenomics in Personalized Medicine

· Pharmacoproteomics in Personalized Medicine

· Metabolomics Personalized Medicine

· Personalized in Healthcare

· Non-genomics Personalized Medicine

· Personalized Biological Therapies

· Personalized Management of Cancer Therapy

· Personalized Management of Infectious Diseases

· Personalized Management of Neurological Disorders

· Personalized Management of Psychiatric Disorders

· Personalized Management of Cardio Vascular

· Personalized Management of Pulmonary Disorders

· Personalised Management of Genetic Disorders

· Personalized Management of Immune Disorders

· Personalized Non-Pharmacological Therapies

· Regulatory of Personalized Medicine

· Economics of Personalized Medicine

· Ethics of Personalized Medicine

· Developed of Personalized Medicine

· Future of Personalized Medicine

Conference series LLC would like to convey a warm gratitude to all the Honorable guests and Keynote Speakers of Euro Personalized Medicine 2017:

Our special thanks to the editors of Journal of Pharmacogenomics & Pharmacoproteomics, Translational Medicine and Journal of Molecular and Genetic Medicine,Advances in Molecular Diagnostics and the organizing committee members, Chair and Co-Chairs for their immense support and beneficial approach.

With the enormous feedback from the participants and supporters of Personalized Medicine 2016, Conferences Series LLC is glad to announce 8th European Conference on Predictive, Preventive & Personalized Medicine & Molecular Diagnostics to be held during August 20-21, 2018 Rome Italy.

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