Rong GaoThe Second Hospital of Jilin University, Changchun, Jilin, China Center for Research on Environmental Disease, College of Medicine, University of Kentucky, Lexington, Kentucky, United States of AmericaPLoS ONE 9:e98909. 2014

..Taken together, these data suggest that increasing PKG activity ameliorates renal fibrosis in part through regulation of macrophage and tubular cell function, leading to reduced TGF-β-induced fibrosis. ..

Yanzhang LiGraduate Center for Nutritional Sciences, University of Kentucky, Lexington, Kentucky, United States of AmericaPLoS ONE 6:e26656. 2011

..However, the direct effect of TSP1 on obesity and insulin resistance is not known. Therefore, we investigated the role of TSP1 in mediating obesity-associated inflammation and insulin resistance by using TSP1 knockout mice...

..These leptin-stimulated effects were abolished in TSP1-deficient mesangial cells. Taken together, these data suggest that TSP1 is an important mediator for obesity- or hyperleptinemia-induced kidney dysfunction. ..

..Taken together, these results suggest that PKG-I protects against renal IRI, at least in part through inhibiting inflammatory cell infiltration into the kidney, reducing kidney inflammation, and inhibiting tubular cell apoptosis...

Rong GaoThe Second Hospital of Jilin University, Changchun, Jilin, China Center for Research on Environmental Disease, College of Medicine, University of Kentucky, Lexington, Kentucky, United States of AmericaPLoS ONE 9:e98909. 2014

..Type 1 diabetes onset further augmented the urinary albumin excretion and glomerular hypertrophy in the USF2 (Tg) mice. These findings suggest that overexpression of USF2 accelerates the development of diabetic nephropathy...

..These results suggest that Cr(VI) induced a mitochondrial-mediated and caspase-dependent apoptosis in skin epidermal cells through activation of p53, which are mainly mediated by reactive oxidants generated by the chemical...