Francine considers Katchoo her best friend; Katchoo is in love with Francine. David is in love with Katchoo (a relationship which Katchoo herself is deeply confused about).

This love triangle plays itself out over a second plot element, a thriller concerning the shadowy 'Big Six' organization. Its leader is a woman named Darcy Parker, who uses highly trained women (of whom Katchoo was one) to infiltrate and to an extent control the American political system.