BEC

Cat No.

CEI-0641

Description

A potent, slow-binding competitive inhibitor of recombinant rat liver arginase I with a Ki of 0.4-0.6 µM. It is also a potent inhibitor of human arginase II with Ki values of 0.31 µM and 30 nM at pH 7.5 and 9.5, respectively. It does not inhibit murine iNOS at concentrations up to 1 mM. BEC significantly enhances NO-dependent relaxation of human penile corpus canvernosum smooth muscle in vitro at concentrations between 0.1-1.0 mM.