TP73/ANGPTL1 FISH

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Description

A locus-specific dual-colour probe set for the detection of gains or losses of the TP73/ANGPTL1 regions. This probe set may also be used in other disease types/referral reasons for eluciation of rearrangements.

Also known as

1p/1q FISH

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Additional information

FISH (fluorescence in-situ hybridisation) is a technique which used as both a stand-alone test and as an adjuct to G-band analysis. It uses uses fluorescently-labelled complementary sequesnces of DNA applied to material fixed on slides, this allows visulisation of specific sequences in both metaphase and interphase cells. Probes are designed for the analysis of specific rearrangments, or may be used for the enumeration of loci present in a cell. The information gained from FISH analyses may be useful for both diagnostic and prognostic purposes. May be performed as a reflex test on existing karyotyping cases.