The destruction of the Earth by use of iTunes, as foreshadowed by the iTunes End User License Agreement.
Below are the words that have accurately predicted the morbid outcome of the near-future of computer software used for organizing digital music libraries.
"You also agree that you will not use these products for...the development, design, manufacture or production of missiles, or nuclear, chemical or biological weapons."

"Do you fear the iPocalypse?"
Preacher: "The iPocalypse is a-comin'!"
That Satanist kid who used his parents' house as a church when they left for the weekend: "I hereby summon the four demons of the iPocalypse!"
Or...

Man who walks into an airport carrying only his laptop case, going through the packs of security, then taking out his laptop:
"EVERYONE, GET DOWN! I'VE GOT iTUNES AND I'M NOT AFRAID TO USE IT! IT'LL BE THE F**KIN' iPOCALYPSE!"

The Internet works on IP Version 4 (IPv4) addressing. It is predicted that sometime late in 2011 that no more IPv4 addresses will be available. No doubt the press will declare the end of the Internet, and that all communications will soon cease. This the the IPOCALYPSE.

Predictions on the demise of the world, the end of the communications, and what companes will be affected will run rampant in the mainstream news. Some people will load up their women, guns and bibles and head to their cabins in Montana.

Of course, engineers have already thought about the solution, with the uber-practical name of IP Version 6, and are just waiting for the business and liberal arts fraternities to wake up and spend some money on the transition instead of smelling their armpits before heading out to an arts festival.

After the ipocalypse the Internet will fail and the entire world will collapse into economic failure.

The DDOS effects of millions of Apple purchasers activating a product on launch day. This effect brings not only iTunes and the Apple servers to their knees but effects any of Apple's business partners in the process.

I got the new iPhone but could not activate it for the three days of the iPocalypse

a phenomenon marked by exhaustion of IP addresses that identify destinations for digital traffic. The proposed solution lies in switching over from the existing IPv4 standard to that of IPv6 that allows trillions of Internet addresses vis-à-vis the former that allows a paltry 4 billion or so addresses. The big pool in the sky, a giver of IP addresses and a fast-draining reservoir of addresses maintained by the non-profit organization Internet Corporation for Assigned Names and Addresses (ICANN), is going to run out in the next few weeks. The number of addresses IPv6 allows is a whopping 340 undecillion (followed by 36 zeroes), enough for a trillion people.

Do not worry about an IPocalypse. It is not going to take place any time soon.