"It wouldn't be us playing us," Stamos tells New York's Daily News. "I'm not 100 percent sure, but it would probably take place in the first few years [of the sitcom]." Stamos, who has since starred on ER, has a few actors in mind to play the lead roles.

James Franco would be perfect as Uncle Jesse, he says. "I see Steve Carell as Danny Tanner [originally played by Bob Saget] and Tracy Morgan as Joey Gladstone [originated by Dave Coulier] because he's funny," Stamos continues. And just because recasting the movie doesn't mean Stamos (a spokesperson for Project Cuddle, a charity to prevent infants from being abandoned) isn't tight with his former costars.