Guyabano, herbal medicine - Health Benefits

Guyabano and Diabetes

An article in “African Journal of Traditional Complementary
and Alternative Medicine” about in 2008 have reported that a clinical
study done on rats induced with diabetes mellitus then fed with
guyabano (Annona Muricata Linn) extracts showed positive effects of
lowering the blood sugar levels in animals. Another study reported by
the same publication showed that animals with induced diabetes mellitus
that consumed guyabano extract has showed remarkable increase of
antioxidants in their blood and that there is less liver damage. The
findings of this laboratory animal study suggest that (guyabano) Annona
muricata extract has a protective, beneficial effect on (liver) hepatic tissues
subjected to STZ-induced oxidative stress, possibly by decreasing
lipid peroxidation and indirectly enhancing production of insulin and
endogenous antioxidants. Although the reports suggested that guyabano
extracts have promising medicinal benefits for diabetes mellitus, there
is no sufficient study done on its effects to humans with diabetes.http://www.ncbi.nlm.nih.gov/pubmed/20162039

Guyabano and InflammationIn a report that was published in “International Journal of
Molecular Sciences” dated 2010, Antinociceptive and anti-inflammatory
activities of the ethanol extract from guyabano leaves (Annona muricata
Linn) were investigated in animal models. In a chemically induced
edema to the paw of rats showed that the guyabano ethanol extract has
significantly reduced the exudate volume. These results suggest that
Annona muricata can be an active source of substances with
antinociceptive and anti-inflammatory activities.http://www.ncbi.nlm.nih.gov/pubmed/20559502

Guyabano and CancerIn a study published in the “Journal of Medicinal
Chemistry”, 14 structurally diverse Annonaceous acetogenins, found
in Guyabano extract were identified and tested for their ability to
inhibit the growth of adriamycin resistant human mammary adenocarcinoma
cells. This cell line is known to be multidrug resistant cancer cells.
Some of the acetogenins from the guyabano extract were found to be
more potent than adriamycin and thus may have chemotherapeutic
potential, especially with regard to multidrug resistant tumors..http://www.ncbi.nlm.nih.gov/pubmed/9207950?dopt=Citation

Guyabano and DepressionIn a study published in the “Journal of Pharmacy and
Pharmacology”, extracts from the fruit and the leaves of Guyabano
(Annona muricata - Annonaceae) contains three alkaloids, annonaine (1),
nornuciferine (2) and asimilobine (3), that upon tests have shown to
inhibit binding of [3H]rauwolscine to 5-HTergic 5-HT1A receptors in
calf hippocampus. These results imply that Guyabano fruit (Annona
muricata) possesses anti-depressive effects.http://www.ncbi.nlm.nih.gov/pubmed/9401954#

Guyabano and Antibacterial EffectsIn a report published in “Revista do Instituto de Medicina
Tropical de São Paulo”, a study has been made to determine the
antibacterial effects of aqueous and ethanolic extracts of seeds of
moringa (Moringa oleifera) and pods of guyabano (Annona muricata). The
aqueous extracts of guyabano (annona muricata) showed an antibacterial
effect against Staph aureus and Vibrio cholerae, but the antibacterial
activity by the ethanol extracts of this plant was not demonstrated.http://www.ncbi.nlm.nih.gov/pubmed/20602021

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