"Radioactive" is the only single released from the Kiss solo album Gene Simmons. The song is written by Gene Simmons and produced by Simmons and Sean Delaney. Released in 1979, the song was recorded in the spring of 1978. "Radioactive" reached #47 on the Billboard charts during an 8-week run between April and May 1979. When the single was released, a limited-edition red vinyl 45 rpm album was made available.

"Radioactive" features Bob Seger and Aerosmith guitarist Joe Perry. Approximately one minute of the song was edited from the album version for the single, subsequently removing the Prelude, which features musician Janis Ian on vocals.