However, Spurs winger Erik Lamela and goalkeeper Paulo Gazzaniga have both been dropped.

Inter Milan striker Mauro Icardi has also been left out, having not played since 9 February because of an ongoing dispute with the Serie A club.

Manchester City’s Sergio Aguero and Chelsea’s Gonzalo Higuain also remain absent, having last played for Argentina at the 2018 World Cup.

Argentina captain Messi, his country’s record scorer with 65 goals in 128 games, initially retired from international duty after Copa America final defeat by Chile in June 2016 before reversing his decision less that two months later.

The five-time Ballon d’Or winner’s only major international honour is Olympic gold at the 2008 Games in Beijing, having lost three Copa America finals and been beaten by Germany in the 2014 World Cup final.

Argentina face Venezuela in Madrid at 01:00 GMT on 23 March before playing Morocco in Tangier on 26 March.

The 2019 Copa America runs from 14 June to 7 July in Brazil, with Argentina drawn in Group B alongside Colombia, Paraguay and 2022 World Cup hosts Qatar.