Detail Information

Publications60

George A C MurrellOrthopaedic Research Institute, St George Hospital Campus, University of New South Wales, Sydney, AustraliaJ Shoulder Elbow Surg 16:S208-14. 2007

..In all 3 clinical trials, there was a significant positive beneficial effect of nitric oxide donation to the clinical symptoms and function of patients with Achilles tendinopathy, tennis elbow, and supraspinatus tendinitis...

Understanding tendinopathies

G A MurrellOrthopaedic Research Institute, St George Hospital, University of New South Wales, Sydney, AustraliaBr J Sports Med 36:392-3. 2002

George A C MurrellOrthopaedic Research Institute, University of New South Wales, The St George Hospital, Kogarah, Sydney, New South Wales 2217, AustraliaBr J Sports Med 41:227-31. 2007

..In humans, in three randomised clinical trials, we have shown that NO delivered via a transdermal patch enhances the subjective and objective recovery of patients with tennis elbow, Achilles tendinosis and supraspinatus tendinosis...

Shoulder instability. Diagnosis and management

M CallananSports Medicine and Shoulder Service, Orthopaedic Research Institute, University of New South Wales, St George Hospital Campus, SydneyAust Fam Physician 30:655-61. 2001

..Labral disruptions and capsular laxity can often be restored by minimally invasive (arthroscopic) methods. Rehabilitation aims to enhance the dynamic muscular and proprioceptive restraints to shoulder instability...

George A C MurrellOrthopaedic Research Institute, St George Hospital, Research and Education Centre, University of New South Wales, Level 2, 4 10 South Street, Kogarah, Sydney, NSW, 2217, AustraliaClin Orthop Relat Res 466:1618-24. 2008

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Topical nitric oxide application in the treatment of chronic extensor tendinosis at the elbow: a randomized, double-blinded, placebo-controlled clinical trial

Justin A PaoloniOrthopaedic Research Institute, St George Hospital Campus, University of New South Wales, Sydney, New South Wales, AustraliaAm J Sports Med 31:915-20. 2003

..No treatment has been universally successful. Topical application of nitric oxide has been used effectively to treat fractures and cutaneous wounds in animal models, presumably by stimulation of collagen synthesis in fibroblasts...

..Shoulder dislocations, if managed non-operatively, should not be treated by placing arms in a sling. Rather, placing them in a splint or using a pillow so that the the arm is externally rotated should be considered...

..The results demonstrate that adenovirus can be used to deliver a gene of interest to cultured human rotator cuff tendon cells and healing tendon, with gelatin sponge implantation enhancing adenoviral transfection efficiency in vivo...

The accuracy and reliability of a novel handheld dynamic indentation probe for analysing articular cartilage

R C AppleyardOrthopaedic Research Institute, St George Hospital, University of New South Wales, AustraliaPhys Med Biol 46:541-50. 2001

..The system was shown to be an accurate and reliable tool for rapidly assessing the dynamic biomechanical properties of articular cartilage, while being small enough to be used arthroscopically...

J LinOrthopaedic Research Institute, University of New South Wales, Sydney, AustraliaInflamm Res 50:515-22. 2001

..The sequential pattern of NOS expression in healing fibroblasts suggests that each NOS isoform may play a different role in the healing process and provides opportunities to modify tendon healing in the clinical setting...

Gene expression changes in SNAP-stimulated and iNOS-transfected tenocytes--expression of extracellular matrix genes and its implications for tendon-healing

..This finding suggests heat shock proteins play a role in the cascade of stress-activated programmed cell death and degeneration in tendinopathy and may provide a novel target in preventing tendinopathies...

..Familial inheritance of slipped capital femoral epiphysis (SCFE) is known. It has not been described in non-identical twins. A family where the mother and three of five siblings developed SCFE were investigated and managed...

The effects of time course after anterior cruciate ligament injury in correlation with meniscal and cartilage loss

G A MurrellDepartment of Orthopaedic Surgery, St. George Hospital Campus, University of New South Wales, Sydney, AustraliaAm J Sports Med 29:9-14. 2001

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Repair of partial-thickness rotator cuff tears: a biomechanical analysis of footprint contact pressure and strength in an ovine model

Karin S PetersOrthopaedic Research Institute, St George Hospital Campus, University of New South Wales, Sydney, AustraliaArthroscopy 26:877-84. 2010

..The purpose of this study was to determine whether transtendon repair by use of a novel small-diameter knotless anchor showed enhanced mechanical properties compared with tear completion and repair...

Wei XiaOrthopaedic Research Institute, St George Hospital Campus, University of New South Wales, Kogarah, Sydney, New South Wales 2217, AustraliaJ Orthop Res 24:159-72. 2006

..These results may explain, in part, at least, the beneficial effects of NO donors in animal models and during the treatment of tendonopathies in human clinical trials. ...

A randomised clinical trial evaluating the efficacy of physiotherapy after rotator cuff repair

Kimberley HayesSt George Hospital, University of New South Wales, AustraliaAust J Physiother 50:77-83. 2004

..On the basis of these results, outcomes for subjects allocated to individualised physiotherapy treatment after rotator cuff repair are no better than for subjects allocated to a standardised home exercise regime...

Clinical examination of the unstable shoulder

Anthony TzannesSports Medicine and Shoulder Service, Orthopaedic Research Institute, St George Hospital Campus, University of New South Wales, Sydney, New South Wales, AustraliaSports Med 32:447-57. 2002

..41; P =.02) than the other methods. Each method underestimated rotator cuff tear size by 12%, 30%, 33%, and 38%, respectively. No method was able to determine the size of partial-thickness rotator cuff tears (r < 0.02)...

..Porcine small intestine submucosal grafts have been successful in enhancing soft tissue repair, as demonstrated by animal studies. Currently, there are no reports of the use of such implants in human rotator cuff repair...

The unstable shoulder in the adolescent athlete

Judie WaltonSports Medicine and Shoulder Service and the Orthopaedic Research Institute, St George Hospital Campus, University of New South Wales, Sydney, AustraliaAm J Sports Med 30:758-67. 2002

..The aim of rehabilitation is to enhance the dynamic muscular and proprioceptive restraints to shoulder instability...

..The data suggest that oxidative stress-induced apoptosis in human tendon fibroblasts is mediated via pathway(s) that includes release of cytochrome c from mitochondria to the cytosol and activation of caspase-3...

..Both sodium butyrate and amiloride inhibited the uPAR mRNA levels induced by IFN-alpha or IFN-gamma. These results may provide useful information for the treatment of patients receiving IFN-alpha or IFN-gamma...