Plus produit pour ADRB3 Protéine

Plus protéines pour ADRB3 partenaires d'interaction

Human Adrenergic, beta-3-, Receptor (ADRB3) interaction partners

results of this study have shown a significant association between the Trp64Arg polymorphism in ADRB3 gene and the development of overweight and obesity in Saudi populations; It also has an influence on the levels of lipid, insulin, leptin, and glucose

the association between the Arg64 allele of the Trp64Arg polymorphism of ADRB3 gene, FATMAX, and LDL-cholesterol levels should be interpreted with caution, as it may represent a small portion of complex physiological processes related to lipolysis and metabolism lipids.

Nerve fibers expressing immunoreactivity for beta3AR were abundantly found in the mucosa and muscular layers of the human bladder.

The presence of the Trp64Trp genotype is related to higher TAG level in CTDs and reliably predicts hypertriglyceridemia.

The current meta-analysis demonstrated that Trp64Arg polymorphism in ADRB3 was associated with sus- ceptibility to GDM in the European Caucasian population.

The downregulation of beta-ARs after ureter dilation, particularly for beta1-AR and beta3-AR in the muscular layer, suggests a potential compensatory mechanism involving increased contraction of the ureter to push urine through the obstruction.

The mechanism(s) of downstream beta3 adrenoceptor activation in human corpus cavernosum and in penile artery involves CSE-derived H2S and cGMP elevation. In other words, beta3 relaxation does not need the endothelium but is still able to amplify the cGMP signaling through H2S pathway. This study defines a possible novel pharmacological approach in erectile dysfunction treatment.

There were no differences between the distribution of genotypes and the allele frequencies of the PPARG Pro12Ala, and C1431T polymorphisms and the ADRB3 Trp64Arg polymorphism in normo- and hyperglycaemic women.

the mechanism of beta3-AR-mediated upregulation of hepatic apoA-I expression

ADRB3 gene Trp64Arg mutation was significantly associated with an increased predisposition toward hypertension and elevated systolic/diastolic BP in hypertensive patients, suggesting that Trp64Arg is an important hypertension-susceptibility marker.

It has been shown, that presence of one mutant allele of rs9939609 (gene FTO) and rs4994 (gene ADRB3) leads to statistically significant association with obesity.

In mutant group of beta3 adrenoreceptor gene patients have higher insulin and HOMA levels than wild type group, without relation with metabolic

Pharmacological experiments allowed us to demonstrate that these effects were driven by an Erk1/2-mediated activation of the antioxidant transcription factor PPARg. These results suggest that b3-AR protective effects in the myometrium could be due to its dual antioxidant properties.

body mass index (BMI) >/=25, PRRs of beta-3 adrenergic receptor genotype (Trp/Arg and Arg/Arg) for periodontal disease markers were 0.13 to 0.70, those of PPARgamma genotype (Pro/Pro) were 0.66 to 3.14 and those of the interaction term for the two genotypes were 1.69 to 12.61. Results confirm a positive relation between beta-3 adrenergic receptor genotype & PPAR-gamma genotype

Study reports association of the Arg64 allele of the rs4994 polymorphism of ADRB3 with increased serum urate in Western Polynesian individuals.

beta3-Adrenergic Regulation of EPC Features Through Manipulation of the Bone Marrow MSC Niche.

Findings are of potential physiologic importance as they uncover the antidiuretic effect of beta3-AR stimulation in the kidney.

aerobic exercise training could improve cardiac systolic function and alleviate LV chamber dilation, cardiac fibrosis and hypertrophy in heart failure mice. The mechanism responsible for the protective effects of aerobic exercise is associated with the activation of the beta3-AR-nNOS-NO pathway.

Data (including data from studies in knockout mice) suggest that Adrb3 is dispensable for browning of adipose tissue; here, no differences was observed in cold-induced thermogenic gene expression in brown, white, or beige adipose tissues due to absence of Adrb3; irrespective of duration of cold exposure or sex of mice, no effect of absence of Adrb3 was observed.

injection of a b3-adrenergic receptor (b3-AR) agonist for continuous 5 days increased the number of Ki67-positive brown adipocytes even at Day 1 but not that of SV cells. In addition, the b3-AR antagonist, but not b1-AR antagonist, attenuated the cold exposure-induced increase in the number of Ki67-positive brown adipocytes

A single-dose administration of beta3AR agonist before reperfusion decreased infarct size and resulted in a consistent and long-term improvement in cardiac function in mouse model of myocardial ischemia reperfusion injury.

activation of beta-adrenoceptor reduce the plaque area in the thoracic aorta and play an important anti-atherosclerotic role by regulating lipid metabolism disorders and the SR-B1 signal transduction pathway

small G protein Rac1 is a key regulator of beta(3)AR signaling in cultured aortic endothelial cells with potentially important implications for the pathways involved in adrenergic modulation of eNOS pathways in the vascular wall

A single-dose administration of beta3AR agonist before reperfusion decreased infarct size and resulted in a consistent and long-term improvement in cardiac function in mouse model of myocardial ischemia reperfusion injury.

Up-regulation of cardiac beta3-adrenoreceptor signaling enhances inhibition of left ventricular myocyte contraction and relaxation, exacerbates the dysfunctional calcium channels and may precede the development of alcoholic cardiomyopathy.

Profil protéine ADRB3

Profil protéine

The protein encoded by this gene belongs to the family of beta adrenergic receptors, which mediate catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor is located mainly in the adipose tissue and is involved in the regulation of lipolysis and thermogenesis.