Color test for selective detection of secondary amines on resin and in solution

CloseSection for Immunology and Vaccinology, National Veterinary Institute, Technical University of Denmark

DOI:

10.1021/ol502936d

Abstract:

Resins for solid-phase synthesis give orange to red-brown resin beads selectively when secondary amines are present on the resin when treated with a solution of acetaldehyde and an Fmoc-amino acid in NMP. The method shows good specificity and gives colorless beads when exposed to a variety of other functional groups. Furthermore, the acetaldehyde/Fmoc amino acid method can be used as a selective colorimetric test for secondary amines in solution.