EPHA5

(redirected from ephrin type-A receptor 5)

EPHA5

A gene on chromosome 4q13.1 that encodes a member of the ephrin-A receptor subfamily of receptor tyrosine kinases, which “promiscuously” bind membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signalling into neighbouring cells. EPNA5 is thought to constitute the cognate/functional ligand for EPHA5, acting as an axon guidance molecule during development. EPHA5 may be involved in the development of retinotectal, entorhino-hippocampal and hippocamposeptal pathways; with EFNA5 it also play a role in synaptic plasticity in adult brain by regulating synaptogenesis. In addition to its role in the nervous system, the EPHA5/EFNA5 interaction mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion.

All content on this website, including dictionary, thesaurus, literature, geography, and other reference data is for informational purposes only. This information should not be considered complete, up to date, and is not intended to be used in place of a visit, consultation, or advice of a legal, medical, or any other professional.