Researchers at the University of Illinois at Urbana-Champaign (UIUC) have achieved a major breakthrough in the battle to fight the spread of the human immunodeficiency virus (HIV) using NVIDIA Tesla GPU accelerators, NVIDIA today announced.

Featured on the cover of the latest issue of Nature, the world's most-cited interdisciplinary science journal, a new paper details how UIUC researchers collaborating with researchers at the University of Pittsburgh School of Medicine have, for the first time, determined the precise chemical structure of the HIV "capsid," a protein shell that protects the virus's genetic material and is a key to its virulence. Understanding this structure may hold the key to the development of new and more effective antiretroviral drugs to combat a virus that has killed an estimated 25 million people and infected 34 million more.

UIUC researchers uncovered detail about the capsid structure by running the first all-atom simulation of HIV on the Blue Waters Supercomputer. Powered by 3,000 NVIDIA Tesla K20X GPU accelerators -- the highest performance, most efficient accelerators ever built -- the Cray XK7 supercomputer gave researchers the computational performance to run the largest simulation ever published, involving 64 million atoms.

"It would have been very difficult to run a simulation of this size without the power of GPU-accelerated supercomputing in the Blue Waters system," said Klaus Schulten, professor of physics at the University of Illinois. "We started using GPU accelerators more than five years ago, and GPUs have fundamentally accelerated the pace of our research."

Designed to accelerate a broad range of scientific and technical computing applications, NVIDIA Tesla GPU accelerators are enabling researchers worldwide to make dramatic new breakthroughs across a variety of scientific domains -- including alternative energy, astrophysics, drug development, and climate research, among others. They deliver significantly higher performance and better energy efficiency as compared with CPU-based systems.

"GPUs help researchers push the envelope of scientific discovery, enabling them to solve bigger problems and gain insight into larger and more complex systems," said Sumit Gupta, general manager of the Tesla Accelerated Computing Business Unit at NVIDIA. "Blue Waters and the Titan supercomputer, the world's No. 1 open science supercomputer at Oak Ridge National Labs, are just two of many GPU-equipped systems that are enabling the next wave of real-world scientific discovery."

Capsid May Be Key to More Effective Drugs
With the planned addition of more GPUs to the Blue Waters system, UIUC researchers expect to increase simulation times, providing additional insight into the structure and behavior of the HIV capsid.

The capsid has become an attractive target for the development of new antiretroviral drugs, largely due to the discovery that Rhesus monkeys have developed an immunity to HIV through a protein that disrupts capsid functioning.

The capsid is the protein cell of a virus, containing the virus's genetic material. It protects and "smuggles" the genetic material into the human host cell. Once inside, it uncoats the material and initiates the infection.

No existing HIV drug treatments are designed to target the capsid. However, by providing a better understanding of the structure of the HIV capsid, pharmacologists have a wealth of new information to develop new and potentially more effective antiviral HIV drugs.

Well in scientist dudes and hurah to the nvidia Pr people, I like that nv are taking the credit for selling something other companies also make , whereas there are a great many people just as essential to this simulation work who aren't named at all.

As always, useless. A way one can cure itself of this disease , and many more other is allready known for millenia. This is just another example of how todays resources are used just for the sake of it, just because we can.
Its called drinking your own urine !

Simple, anyone can do it, it doesnt cost anything, and you dont need to know the structure of the virus to make it work. The body works its wonders alone, while you sit on your ass and play world of warcraft.

But like anything in this fucked up society, if it doesnt make profit, its not promoted.
As you have read, this new knowledge is being used to be able to manufacture: '' new and potentially more effective antiviral HIV drugs ".

Profit profit and more profit.
They dont give a fuck on curing people. Its all about profit !

Another example would be the so called folding teams, where people gather togther theyr PCs computing power to solve some other medical problems, also just for the sake of it.

It makes me sick thinking that people like you exist. How dare you say we should not spend money to save peoples lives?

It's all about profit? You will make a lot more profit owning a hotel, a restaurant owner, or any sort of business. Yet these people have devoted half their life studying medicine, to work in a field where they SAVE PEOPLES LIVES. And here you come screaming 'profit, profit'.

It seems like YOU are the one who sits in front of the PC and plays games, rather than ever having worked in a company before. Profit is simply the way of saying 'what I am doing is appreciated by someone' or 'someone finds my product/service useful'.

As always, useless. A way one can cure itself of this disease , and many more other is allready known for millenia. This is just another example of how todays resources are used just for the sake of it, just because we can.
Its called drinking your own urine !

Simple, anyone can do it, it doesnt cost anything, and you dont need to know the structure of the virus to make it work. The body works its wonders alone, while you sit on your ass and play world of warcraft.

But like anything in this fucked up society, if it doesnt make profit, its not promoted.
As you have read, this new knowledge is being used to be able to manufacture: '' new and potentially more effective antiviral HIV drugs ".

Profit profit and more profit.
They dont give a fuck on curing people. Its all about profit !

Another example would be the so called folding teams, where people gather togther theyr PCs computing power to solve some other medical problems, also just for the sake of it.

As always, useless. A way one can cure itself of this disease , and many more other is allready known for millenia. This is just another example of how todays resources are used just for the sake of it, just because we can.
Its called drinking your own urine !

Simple, anyone can do it, it doesnt cost anything, and you dont need to know the structure of the virus to make it work. The body works its wonders alone, while you sit on your ass and play world of warcraft.

But like anything in this fucked up society, if it doesnt make profit, its not promoted.
As you have read, this new knowledge is being used to be able to manufacture: '' new and potentially more effective antiviral HIV drugs ".

Profit profit and more profit.
They dont give a fuck on curing people. Its all about profit !

Another example would be the so called folding teams, where people gather togther theyr PCs computing power to solve some other medical problems, also just for the sake of it.

Im sick of this just when im thinking about it.

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Well the profit part is generally true, but I'm sure if drinking your own piss had worked it wouldn't be the problem it is.

As always, useless. A way one can cure itself of this disease , and many more other is allready known for millenia. This is just another example of how todays resources are used just for the sake of it, just because we can.
Its called drinking your own urine !

Simple, anyone can do it, it doesnt cost anything, and you dont need to know the structure of the virus to make it work. The body works its wonders alone, while you sit on your ass and play world of warcraft.

But like anything in this fucked up society, if it doesnt make profit, its not promoted.
As you have read, this new knowledge is being used to be able to manufacture: '' new and potentially more effective antiviral HIV drugs ".

Profit profit and more profit.
They dont give a fuck on curing people. Its all about profit !

Another example would be the so called folding teams, where people gather togther theyr PCs computing power to solve some other medical problems, also just for the sake of it.

Im sick of this just when im thinking about it.

Click to expand...

you sir are the BIGGEST idiot i have ever met online. 1/2 of what you say doesn't make sense and the rest is just your anger at something you cant/wont participate in cause you think that distributed computing has no merit

Tbh how do we know there isn't already a cure for HIV. There is so much money in the infrastructure related to HIV, ie drugs, clinics, specialist doctors etc, they could have found a cure already and sat on it to continue making money from this infrastructure. Now I am not saying I agree with this if it is happening, but it is a possibility.

I have respect for Nvidia for kickstarting the use of GPU for parallel processing, before their support for CUDA there was flaky support for GPU in the form of OpenCL. Now that they have done the job, people are keen to jump on the hate bandwagon. Nvidia as a whole is pretty profit oriented (which company isn't?), but I am pretty sure somewhere deep in the bowels of Nvidia's research labs, there are a bunch of engineers who set out trying to change the world for the better.

Bytales and to a lesser extent Tigger are fundamentally what is wrong with our world today. Ill informed and deluded by conspiracy.

Of course big pharmaceuticals want to make maximum ill gotten profit (you can do some googling about how they created 'depression' as an illness in Japan and saw their anti-depressant sales soar) but there is a line in the sand.

There are many whacko, crack jobs that say AIDS and HIV can be readily cured by 'piss' or Vitamin C but the hard facts are that there are many not for profit research organisations also fighting the disease and if it was as easy as drinking piss then these good people would have cracked it.

It's also really weird how lunatics with their own little world hate agendas against science use science (the digital tech of the internet) to spread their unintelligent (sometimes faith driven) dire opinions upon the rational majority.

Well, Bytales, I would not wish it upon you normally but if you would be so kind as to go and contract HIV and hence prove to us that drinking your own piss cures you, that would be lovely. Of course nothing is stopping you from saying that is exactly what has happened to you already, such is the allure of the unchecked lie machine of the web.

Bytales and to a lesser extent Tigger are fundamentally what is wrong with our world today. Ill informed and deluded by conspiracy.

Of course big pharmaceuticals want to make maximum ill gotten profit (you can do some googling about how they created 'depression' as an illness in Japan and saw their anti-depressant sales soar) but there is a line in the sand.

There are many whacko, crack jobs that say AIDS and HIV can be readily cured by 'piss' or Vitamin C but the hard facts are that there are many not for profit research organisations also fighting the disease and if it was as easy as drinking piss then these good people would have cracked it.

It's also really weird how lunatics with their own little world hate agendas against science use science (the digital tech of the internet) to spread their unintelligent (sometimes faith driven) dire opinions upon the rational majority.

Well, Bytales, I would not wish it upon you normally but if you would be so kind as to go and contract HIV and hence prove to us that drinking your own piss cures you, that would be lovely. Of course nothing is stopping you from saying that is exactly what has happened to you already, such is the allure of the unchecked lie machine of the web.

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I did NOT say it is happening or that I believe it is, just that it could be, neither am I a nut job or a conspiracy believeing whacko, I'll leave that to the americans, all I said is it could be true and we will never know. So don't put words, thoughts or beliefs into my head.

people in the 'know' knew HIV/AIDS was a US government engineered diseased developed in the 80s used for population control, they had the cure since day one, billions of dollars has been "dumped" into these so called "research" for what? if they wanted you to have the cure you would have it, the fact is a cure isn't meant to be found and all these useless research isnt going to do squat. all these marketing bullshit just to make a profit. Cmon people, when will you wake the f**k up.

people in the 'know' knew HIV/AIDS was a US government engineered diseased developed in the 80s used for population control, they had the cure since day one, billions of dollars has been "dumped" into these so called "research" for what? if they wanted you to have the cure you would have it, the fact is a cure isn't meant to be found and all these useless research isnt going to do squat. all these marketing bullshit just to make a profit. Cmon people, when will you wake the f**k up.

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the only thing i have to say is doesn't it make you wonder a bit why Magic Johnson looks healthier than most men his age, yet he is HIV positive....

the only thing i have to say is doesn't it make you wonder a bit why Magic Johnson looks healthier than most men his age, yet he is HIV positive....

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the objective of the disease is to create a near "painless" death for most carriers, and allows them to "almost" live their entire life normally, ironically, the trick in the disease is that its able to be spread by the most desirable activity of mankind - sex. However it does help stabilize population growth to a degree.

Considering HIV killed only in the tens of millions, and considering world population growth is virtually unaffected by HIV, you're wrong. It takes mid-school statistics to see that.

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please use your brain, HIV isn't designed to kill, it (among with many other things) is used to contribute to the effect of a moderate population control, like I said, when you put a frog into a boiling water it will leap out immediately, but when you put it into cold water and bring it to its boiling point, the frog will cook itself to death without realizing it. we humans, are no different.

please use your brain, HIV isn't designed to kill, it (among with many other things) is used to contribute to the effect of a moderate population control, like I said, when you put a frog into a boiling water it will leap out immediately, but when you put it into cold water and boil it, the frog will cook itself to death without realizing it. we humans, are no different.

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You need to kill, to control population. HIV doesn't deter two healthy people from producing dozens of babies.

You need to kill, to control population. HIV hasn't deterred two healthy people from producing dozens of babies.

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no, HIV is a long term goal, it will gradually become more effective over time. or generations. HIV has a R-Knot of about 2-5, and is un-curable, the R-knot is especially effective when a given disease is un-curable. if you wonder what that is, I suggest you do some reading.

Tbh how do we know there isn't already a cure for HIV. There is so much money in the infrastructure related to HIV, ie drugs, clinics, specialist doctors etc, they could have found a cure already and sat on it to continue making money from this infrastructure.

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simple answer is profit. if you find the cure to HIV/cancer, cold fusion, zero point energy or anything else you just patent it and price it as high as you want, make more money than god

It makes me sick thinking that people like you exist. How dare you say we should not spend money to save peoples lives?

It's all about profit? You will make a lot more profit owning a hotel, a restaurant owner, or any sort of business. Yet these people have devoted half their life studying medicine, to work in a field where they SAVE PEOPLES LIVES. And here you come screaming 'profit, profit'.

It seems like YOU are the one who sits in front of the PC and plays games, rather than ever having worked in a company before. Profit is simply the way of saying 'what I am doing is appreciated by someone' or 'someone finds my product/service useful'.

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I have studied medicine and i do practice medicine now, and have seen first hand the horrors of modern medicine, so please spare me your intelligent comments. It is crystal clear you have no understanding of how the human body really functions, or what urine therapy is good for or is not good for.

I was simply pointing out the fact that what are they doing is a simple waste of human and energy resources, the way they tackled the problem. They trying to find a cure for something that is already curable, granted, but is not common knowledge.

And its not they're fault really. Such knowledge (that drinking urine can cure a lot of ilness for which modern medicine tells are there are no cures , and i am not referring only to this, there a ton more examples along this line)that is being systematically suppressed, and stupidly enforced by people such as yourself (who don't bother to make the smallest research in this regard, and choose to ridicule it the first chance they got), is and will still be the cause of much human suffering.

I could comment a lot more on this subject, but this is not the place to comment such things.

Screw the fact that NV powered this breakthrough, shouldn't the news just be that there has been a major advancement in HIV research?
If you ask me, that's much more important than some bullshit PR. People matter more.

people in the 'know' knew HIV/AIDS was a US government engineered diseased developed in the 80s used for population control, they had the cure since day one, billions of dollars has been "dumped" into these so called "research" for what? if they wanted you to have the cure you would have it, the fact is a cure isn't meant to be found and all these useless research isnt going to do squat. all these marketing bullshit just to make a profit. Cmon people, when will you wake the f**k up.

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Yep. More of a NWO thing than a US government thing. They weren't planning on it jumping out of Africa though, i don't think.