Using a cross-sectional patient study and a well-characterized murine model of dry eye disease (DED), the authors investigated the immunoregulatory function of interleukin-22 (IL-22) in the pathogenesis of DED. [Mucosal Immunol]
Abstract

Scientists studied the role of RNY-derived small RNAs (s-RNYs) in human and mouse monocytes/macrophages and have shown that in lipid-laden monocytes/macrophages s-RNY expression is timely correlated to the activation of both NF-κB and caspase 3-dependent cell death pathways. [Cell Death Dis]
Full Article

Investigators showed that in transgenic mice expressing truncated IK cytokine, inflammatory arthritis symptoms were ameliorated as the result of suppression of the differentiation of TH1 and TH17 cells and of macrophage activation. [Sci Rep]
Full Article

Decreased interferon-γ (IFN-γ) production by hepatic CD4+ T cells in CD24-deficient mice was detected, which was correlated with downregulated phosphorylation of STAT1 in hepatic tissue. In vitro experiments also supported the conclusion that CD24 deficiency impaired IFN-γ production by CD4+ T cells following concanavalin A, CD3/CD28 and phorbol myristate acetate/ionomycin stimulation. [Cell Mol Immunol]
Full Article

The authors discuss the major components of the microbial community in the gut and how its members collectively and individually exert regulatory roles in the host immune system and lymphoid structure development, as well as the functions of several major immune cell types. [Cell Mol Immunol]
Abstract

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Sanofi and ImmuNext, Inc., announced an agreement focused on the development of a novel antibody with the potential to treat a range of autoimmune diseases including lupus and multiple sclerosis. [sanofi-aventis U.S. LLC.]
Press Release

Three immunology researchers share 2017’s Crafoord Prize in Polyarthritis, for which the prize money is 6 million Swedish krona. The research being rewarded deals with the discovery of regulatory T cells, cells that can be regarded as our immune system’s security guards. [The Crafoord Prize (PR Newswire Association LLC.)]
Press Release

One of the world’s most influential global health charities says that the research it funds cannot currently be published in several leading journals, because the journals do not comply with its open-access policy. [Nature News]
Editorial

Federal officials released a plan to help U.S. agencies decide whether to fund controversial studies that make viruses more dangerous. The guidance may finally bring an end to a moratorium that has kept a handful of experiments funded by the Department of Health and Human Services on hold for more than two years. [ScienceInsider]
Editorial