HOOVER, Alabama -- Chicago White Sox pitcher Phil Humber, who threw the 21st perfect game in Major League history on April 21, will take the mound Wednesday at Regions Park in a rehab assignment with the Double-A Birmingham Barons.

The first pitch against the Tennessee Smokies is set for 7:05 p.m.

Humber is on the disabled list and was placed there June 22 with a strained right elbow. Before the injury, he was 3-4 with a 6.01 ERA.

In two rehab starts with the Charlotte Knights, Humber went 0-1 with a 5.68 ERA.

Humber was named the American League Player of the Week in April. This will be his first appearance in a Barons uniform. Humber came up with the New York Mets.