Effects

No human studies are available on for any exposure route. Similarly, no studies are available for animals exposed via the inhalation route, and negligible information is available for animals exposed via the dermal route. Several studies report a decrease in postnatal survival for offspring of dogs, rats, and mice exposed to dieldrin by the oral route, although many of these studies are flawed. Teratogenic effectts have been observed in only a limited number of the studies performed to assess developmental toxicity.

There were only two studies on in vivo exposure of humans to dieldrin. Both were limited due to concomitant exposure to other pesticides and inconclusive route and dose of exposure.Studies investigating the in vitro genotoxic effects of dieldrin provide no conclusive evidence for genotoxic effects, particularly for direct action on the DNA molecule.

One study in humans attempted to correlate blood levels of dieldrin with premature labor or spontaneous abortions in pregnant women, however, this study failed to establish causality. No other human data regarding reproductive effects of dieldrin were located. Studies in laboratory animals exposed orally to dieldrin present conflicting data on the ability of these agents to cause decreased fertility. No studies in animals were found regarding reproductive effects of exposure by the inhalation or dermal routes.