Gliederung

Weight reduction lead generally to a substancial improvement of the carbohydrate and lipid metabolism. This is also seen by the serotonin- and norepinephrine reuptake inhibitor sibutramine (sib). On the other hand it is unknown if various antihypertensive combination regimes can influence these effects.

The weight reduction was significant higher in the groups A and B, treated with ACEI/calciumantagonist combinations (-6.7, -6.0 %) compared to group C treated with betablocker and diuretic (-3.3 %). The effects of sib on metabolic parameters in these different groups are listed in Table 1 [Tab.Â 1].