HLA disease association studies and HLA pharmacogenetic testing

It is known that certain HLA alleles are associated with increased or reduced susceptibility to various diseases. The HLA allele may also be related to the seriousness of the disease. HLA testing can be used for supporting diagnostics and assessing the hereditary risks.

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Pharmacogenetics studies the impact of genes on the effectiveness and safety of pharmaceutical products. Depending on hereditary factors, a certain dose of a specific drug may cause adverse effects in one patient, but be well suited for another patient. With the help of pharmacogenetic testing it is possible to plan the patient's drug therapy as individually as possible, taking into account the hereditary factors. HLA testing can also be used for investigation of unexpected adverse reactions.