Indicate
by check mark whether the registrant files or will file annual reports under cover

Form 20-F
or Form 40-F.

Form 20-F ☒
Form 40-F ☐

Indicate
by check mark if the registrant is submitting the Form 6-K in paper as permitted by

Regulation S-T
Rule 101(b)(1): ____

Indicate
by check mark if the registrant is submitting the Form 6-K in paper as permitted by

Regulation S-T
Rule 101(b)(7): ____

This
Report on Form 6-K (including exhibits thereto) is hereby incorporated by reference into the registrant’s Registration Statements
on Form F-3 (File Nos. 333-195124, 333-199033, 333-204795, 333-209037 and 333-220644), to be a part thereof from the date on which
this report is submitted, to the extent not superseded by documents or reports subsequently filed or furnished.

On January 24, 2019, Can-Fite BioPharma
Ltd. (the “Company”) announced that it will hold a Special Meeting of Shareholders on March 4, 2019 at 4:00 P.M. (Israel
time) at the Company’s offices in Petach-Tikva, Israel. In connection with the meeting, the Company furnishes the following
documents:

1.

A
copy of the Notice and Proxy Statement with respect to the Company’s Special Meeting of Shareholders describing the
proposal to be voted upon at the meeting, the procedure for voting in person or by proxy at the meeting and various other
details related to the meeting, attached hereto as Exhibit 99.1;

2.

A
form of Proxy Card whereby holders of ordinary shares of the Company may vote at the meeting without attending in person,
attached hereto as Exhibit 99.2; and

3.

A
form of Voting Instruction Card whereby holders of American Depositary Shares of the Company may vote at the meeting without
attending in person, attached hereto as Exhibit 99.3.