Referring to the particular features of mine transportation operation, which was being scheduled, organized and closed, put forward the operation organization model and external interface of autonomous mine haulage system, and the key points in the system design was sorted out. On this basis, the system architecture of autonomous open-pit mine haulage system was proposed as being composed of ground management and monitoring subsystem, vehicle mounted automatic driving subsystem and data communication subsystem, and the function requirements for each subsystem under the architecture were allocated. The operation scenarios of the autonomous mining haulage system were illuminated. The extension of the basic ideas and system architecture of the autonomous open-pit mine haulage system to the similar application field was also prospected.