CONTRAINDICATIONS

Do not co-administer aliskiren with xxxx in patients with diabetes (see PRECAUTIONS, Drug Interactions).

PRECAUTIONS

Drug Interactions

Dual Blockade of the Renin-Angiotensin System (RAS)

Dual blockade of the RAS with angiotensin receptor blockers, ACE inhibitors, or aliskiren is associated with increased risks of hypotension, hyperkalemia, and changes in renal function (including acute renal failure) compared to monotherapy. Closely monitor blood pressure, renal function and electrolytes in patients on xxxx and other agents that affect the RAS. Do not co-administer aliskiren with xxxx in patients with diabetes. Avoid use of aliskiren with xxxx in patients with renal impairment (GFR <60ml/min).

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