Does Vitamin D Decrease Risk of Respiratory Infections?

PURPOSE:

METHODS:

Systematic Review and Meta-Analysis

RESULTS:

25 randomized controlled trials were surveyed and 10,933 participants were included. Supplementation with vitamin D was found to reduce the risk of acute respiratory tract infections among all participants (odds ratio 0.88, 95% CI 0.81-0.96, P<0.001). In subgroup analysis, protective effects were observed in individuals who received daily or weekly vitamin D. Protective effects were stronger among those with baseline 25-hydroxyvitamin D levels <25 nmol/L (odds ratio 0.30, 95% CI 0.17 – 0.53) than those with higher levels (odds ratio 0.75, 95% CI 0.60-0.95, P=0.006). Vitamin D did not affect the risk of serious adverse events or death due to any cause. The overall quality of evidence was of high quality. It appears that vitamin D supplementation is safe and protects against acute respiratory infections, particularly in those individuals who are vitamin D deficient.

Disclosure of Unlabeled Use

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. The planners of this activity do not recommend the use of any agent outside of the labeled indications.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of the planners. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

Disclaimer

Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information
presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patient’s conditions and possible contraindications and/or dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities.

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