He starts with Paul Ehrlich's antitreponemal arsenicals and ends with the antisense agents now in early clinical trials for the treatment of autoimmune diseases and cancer, covering in the process the development of antibacterial and antiviral agents, vaccines, antimetabolites, and hormone-based antineoplastic agents.

III] and the trivalent methylated arsenicals that are produced in the course of iAs metabolism--methylarsonite (MAsIn) and dimethylarsinite (DMAsHI)--play key roles in these mechanisms (Douillet et al.

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