role of BFT in human host beta-defensin 2 induction from intestinal epithelial cells, HT-29 and Caco-2, requiring the presence of NF-kappaB binding sites. Also binding of NF-kappaB to the hBD-2 promoter is required for the induction of the hBD-2 gene in BFT-stimulated intestinal epithelial cells, while AP-1 is not involved, regulation, overview. Heat-labile enterotoxin BFT plays an essential role in host mucosal inflammation

the enzyme plays an essential role in mucosal inflammation and affects the expression of ICAM-1 and monocytic adhesion to endothelial cells. Stimulation of HUVECs and rat aortic endothelial cells with Bacteroides fragilis enterotoxin results in the induction of ICAM-1 expression

enterotoxin plays an essential role in mucosal inflammation and upregulates lipocalin-2 expression in intestinal epithelial cells through the activation of mitogen-activated protein kinases and the activator protein-1 signaling pathway

the enzyme hydrolyzes the extracellular domain of several protein substrate, e.g. of E-cadherin to interrupt the intercellular adhesion increasing the permeability of the epithelium, and causing intracellular redistribution of actin with morphologic changes and release of beta-catenin

the cytopathic effect of the enzyme is only seen in cells that can form tight junction and polarized monolayers, the enzyme affects the barrier function of the epithelium and decreases the transpithelial electrical resistance of monolayers, overview, the enzyme stimulates the recruitment of polymorphs to the lamina propria and seceretion of interleukin-8, epithelial neutrophil-activating peptide-78, and growth-related oncogene-alpha from colonocytes, overview

the cytopathic effect of the enzyme is only seen in cells that can form tight junction and polarized monolayers, the enzyme affects the barrier function of the epithelium and decreases the transpithelial electrical resistance of monolayers, overview, the enzyme stimulates the recruitment of polymorphs to the lamina propria and seceretion of interleukin-8, epithelial neutrophil-activating peptide-78, and growth-related oncogene-alpha from colonocytes, overview

the cytopathic effect of the enzyme is only seen in cells that can form tight junction and polarized monolayers, the enzyme affects the barrier function of the epithelium and decreases the transpithelial electrical resistance of monolayers, overview, the enzyme stimulates the recruitment of polymorphs to the lamina propria and seceretion of interleukin-8, epithelial neutrophil-activating peptide-78, and growth-related oncogene-alpha from colonocytes, overview

the cytopathic effect of the enzyme is only seen in cells that can form tight junction and polarized monolayers, the enzyme affects the barrier function of the epithelium and decreases the transpithelial electrical resistance of monolayers, overview, the enzyme stimulates the recruitment of polymorphs to the lamina propria and secretion of interleukin-8, epithelial neutrophil-activating peptide-78, and growth-related oncogene-alpha from colonocytes, overview

the cytopathic effect of the enzyme is only seen in cells that can form tight junction and polarized monolayers, the enzyme affects the barrier function of the epithelium and decreases the transpithelial electrical resistance of monolayers, overview, the enzyme stimulates the recruitment of polymorphs to the lamina propria and secretion of interleukin-8, epithelial neutrophil-activating peptide-78, and growth-related oncogene-alpha from colonocytes, overview

the cytopathic effect of the enzyme is only seen in cells that can form tight junction and polarized monolayers, the enzyme affects the barrier function of the epithelium and decreases the transpithelial electrical resistance of monolayers, overview, the enzyme stimulates the recruitment of polymorphs to the lamina propria and secretion of interleukin-8, epithelial neutrophil-activating peptide-78, and growth-related oncogene-alpha from colonocytes, overview

the enzyme hydrolyzes the extracellular domain of several protein substrate, e.g. of E-cadherin to interrupt the intercellular adhesion increasing the permeability of the epithelium, and causing intracellular redistribution of actin with morphologic changes and release of beta-catenin

the cytopathic effect of the enzyme is only seen in cells that can form tight junction and polarized monolayers, the enzyme affects the barrier function of the epithelium and decreases the transpithelial electrical resistance of monolayers, overview, the enzyme stimulates the recruitment of polymorphs to the lamina propria and seceretion of interleukin-8, epithelial neutrophil-activating peptide-78, and growth-related oncogene-alpha from colonocytes, overview

the cytopathic effect of the enzyme is only seen in cells that can form tight junction and polarized monolayers, the enzyme affects the barrier function of the epithelium and decreases the transpithelial electrical resistance of monolayers, overview, the enzyme stimulates the recruitment of polymorphs to the lamina propria and seceretion of interleukin-8, epithelial neutrophil-activating peptide-78, and growth-related oncogene-alpha from colonocytes, overview

the cytopathic effect of the enzyme is only seen in cells that can form tight junction and polarized monolayers, the enzyme affects the barrier function of the epithelium and decreases the transpithelial electrical resistance of monolayers, overview, the enzyme stimulates the recruitment of polymorphs to the lamina propria and seceretion of interleukin-8, epithelial neutrophil-activating peptide-78, and growth-related oncogene-alpha from colonocytes, overview

the cytopathic effect of the enzyme is only seen in cells that can form tight junction and polarized monolayers, the enzyme affects the barrier function of the epithelium and decreases the transpithelial electrical resistance of monolayers, overview, the enzyme stimulates the recruitment of polymorphs to the lamina propria and secretion of interleukin-8, epithelial neutrophil-activating peptide-78, and growth-related oncogene-alpha from colonocytes, overview

the cytopathic effect of the enzyme is only seen in cells that can form tight junction and polarized monolayers, the enzyme affects the barrier function of the epithelium and decreases the transpithelial electrical resistance of monolayers, overview, the enzyme stimulates the recruitment of polymorphs to the lamina propria and secretion of interleukin-8, epithelial neutrophil-activating peptide-78, and growth-related oncogene-alpha from colonocytes, overview

the cytopathic effect of the enzyme is only seen in cells that can form tight junction and polarized monolayers, the enzyme affects the barrier function of the epithelium and decreases the transpithelial electrical resistance of monolayers, overview, the enzyme stimulates the recruitment of polymorphs to the lamina propria and secretion of interleukin-8, epithelial neutrophil-activating peptide-78, and growth-related oncogene-alpha from colonocytes, overview

BFT-2 reveals a major band of 20000 Da with faint bands in some preparations at 70000 Da and 100000 Da, BFT-1 reveals a major band at 22000-23000 Da with fainter bands in some preparations at 70000 Da and 100000 Da, SDS-PAGE

among stool strains from colon cancer patients, bft-1 is found to be more common than bft-2, isoform bft-1 is also found in almost all isolates from extraintestinal sites, strain NCTC 11295 harbours the isoform bft-2

among stool strains from colon cancer patients, bft-1 is found to be more common than bft-2, isoform bft-1 is also found in almost all isolates from extraintestinal sites, strain NCTC 11295 harbours the isoform bft-2