Barcelona hosts Chelsea on Wednesday, with Sevilla traveling to Man United a day earlier in the four remaining round of 16 games.

On Tuesday and Wednesday, fans will be treated to more exciting Champions League games. While many will have their eyes on Wednesday's Camp Nou clash between Barcelona and Chelsea, there are many other interesting ties to follow.

Man United, having earned a 0-0 draw at Sevilla, will now host the Spanish outfit in their attempt to make the quarter-final. That game, alongside Roma vs Shakhtar Donetsk, are the two games scheduled for Tuesday.

The following day, the Blaugrana and the Blues will lock horns. The scoreline is currently 1-1, meaning there is a lot left to play for. Elsewhere, Bayern Munich travels to Besiktas with a commanding 5-0 aggregate lead. Here are 10 things to watch out for in the midweek matches.

1. Sevilla could win their first Champions League round of 16 tie

The Spanish club has never made it past this round in the Champions League but could put that awful record to an end should they beat Man United.

Manchester United will look to reach the quarter-finals for the first time in 4 years against Sevilla, who have never won a round of 16 tie in the tournament. #UCLpic.twitter.com/y3syAFrvpZ

6. The Blaugrana to move level with the Blues in the head-to-head record

These two sides have faced off 13 times in this competition. Barcelona has won only three times compared to Chelsea’s four victories (D6).

7. Will the London giant end Barcelona’s unbeaten home run?

The Catalan side has not tasted defeat in Camp Nou in the Champions League in 24 games (W22, D2). This is an unbeaten run that began in September 2015.

8. Will Messi score his 601st goal in Wednesday’s clash?

Messi scored his 600th career goal in the 1-0 victory over Atletico Madrid but missed Barcelona following game due to the birth of his child. Having ended his hoodoo against the Blues, he will now be keen on adding to his goals tally when Conte’s side arrives at Camp Nou.