Although the three subspecies of Silene caroliniana have overlapping ranges of distribution, subsp. caroliniana occurs predominently in the southeastern United States, subsp. pensylvanica in the northeast, and subsp. wherryi on the western side of the Appalachians. Intermediate plants are occasionally encountered. A hybrid between subsp. wherryi and S. virginica was reported by J. A. Steyermark (1963), and a hybrid swarm between subsp. pensylvanica and S. virginica by R. S. Mitchell and L. J. Uttal (1969).