Freebase(0.00 / 0 votes)Rate this definition:

GLIMMER

In bioinformatics GLIMMER was the first system for finding genes that used the interpolated Markov model formalism. It is effective at finding genes in bacteria, archaea, and viruses, typically finding 98–99% of all protein-coding genes. The GLIMMER software is open source and can be found at the links below. It is maintained by Steven Salzberg, Art Delcher, and their colleagues at the Center for Bioinformatics and Computational Biology at Johns Hopkins University.
Because of its high accuracy, Glimmer is the system of choice for genome annotation efforts on a wide range of bacteria, archaeal, and viral species. In a large-scale reannotation effort at the DNA Data Bank of Japan. Kosuge et al. examined the gene finding methods used for 183 genomes. They reported that of these projects, Glimmer was the gene finder for 49%, followed by GeneMark with 12%, with other algorithms used in 3% or fewer of the projects. Glimmer was used by the DNA Databank of Japan to re-annotate all bacterial genomes in the International Nucleotide Sequence Databases. It is also being used by this group to annotate viruses. Glimmer is part of the bacterial annotation pipeline at the National Center for Biotechnology Information, which also maintains a web server for Glimmer, as do sites in Germany, Canada, and elsewhere.