Sheen stars as the title character, a successful graphic designer whose fame, money and charm have made him irresistible to women. When his girlfriend breaks up with him, his life swirls into a downward spiral of doubt, confusion and reflection. Through delirious fantasies involving his many failed romances, he begins the hard road of self-evaluation to come to terms with life without her.

In addition to writing and directing duties, Roman Coppola is producing the pic with Youree Henley. Production is currently under way in Los Angeles.

Independent has come on board to handle international sales for the project, which will be introduced at the forthcoming AFM in Santa Monica with a promo teaser screening for buyers in the market office. Cinetic is handling North American sales.

Murray is notoriously picky about which projects he commits to, which signals his confidence in Coppola’s pic. Thesp, who recently appeared in the indie “Get Low,” next stars in Wes Anderson’s “Moonrise Kingdom” and Roger Michell’s “Hyde Park on Hudson,” in which he plays Franklin D. Roosevelt opposite Laura Linney and Olivia Williams.

CAA-repped Winstead, who currently stars in Universal’s remake of “The Thing,” recently wrapped James Ponsoldt’s indie “Smashed,” which hails from Super Crispy Entertainment.

Arquette, who is ramping up her feature career again after spending several years committed to her NBC series “Medium,” will soon be seen alongside Eva Mendes and Matthew Modine in Patricia Riggen’s dramedy “Girl in Progress.” She is repped by Gersh and 3 Arts Entertainment.