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Faustman holds that BCG vaccination's primary role in this case is to induce TNF-a expression, and that TNF-a's primary role in this case is to kill the defective autoreactive T cells after they have developed, implying that treatment with BCG will only work with patients who are already diabetic.
Faustman put her theory to the test and treated three long-term diabetics with BCG to see whether it would have any effect on their disease status.
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And here’s where things get interesting for a cure-seeking diabetic: when scientists saw that cells were flooding islets with TNF-a, they decided to see what would happen if they changed the levels of TNF-a in mouse pancreases– and they found that changing the levels of TNF-a changes whether a mouse will get diabetes.
Now take a guess: we have a blaring distress signal, TNF-a, that turns on all the cells of the adaptive immune system, and we have a... Read more

I have been extremely happy with the Omnipod and require less insulin than I used to because I never detach. I feel that my work outs are better now and I am more comfortable in my daily routine.
In April of this year, I decided sign up for run my first “Mudder” race called the Rugged Maniac. The Rugged Maniac is a 5K mud run full of military-style obstacles, designed by British Special Forces. Read more

Last week, diabetes headlines were dominated by a new study from the Faustman Lab at Massachusetts General Hospital, published on Wednesday, August 8th on PLoS One, suggesting that a 90-year-old tuberculosis vaccine called BCG might hold promise for people living with type 1 diabetes. “Human Study Reignites Debate Over Controversial Diabetes ‘Cure,’” wrote Reuters. “Diabetes May Be Reversed By Long-Used Vaccine for TB,” proclaimed Bloomberg news. Read more

When Dr. Mariela Glandt, an endocrinologist, volunteered to treat African refugees in Tel Aviv, she had no idea she would meet a type 1 diabetic like Samuel Agant, 28, from South Sudan. Below, Dr. Glandt shares Samuel’s story of living on the streets of Tel Aviv with type 1 diabetes, without a work permit, without food, and without a constant supply of insulin.
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First, the new Enlite sensor — and I really should use “new” in quotation marks because it has been available in Europe for about a year — is much more comfortable and accurate than previous Minimed sensors. Second, the Veo pump itself has a glucose suspend feature, meaning that if the Enlite sensor detects your blood glucose is below 70, it can stop insulin delivery on its own. Read more