Summary: Cancer-associated fibroblasts constitute a functionally heterogeneous mesenchymal cell population in the tumor microenvironment. This ‘At a glance’ article reviews their origin and their pro- and antitumor properties.

Summary: This Review describes the currently used animal models of critical-sized bone defects and the regenerative bone tissue engineering strategies used in these models, as well as the application of bone tissue engineering for the advancement of cancer xenograft models.

Summary: A novel genetically engineered rabbit model of MPL syndrome, generated by CRISPR/Cas9-mediated mutation of FBN1, mimics the histopathological changes and functional defects of MPL syndrome seen in the clinic.

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