Representative Issa, whose committee is investigating Fast and Furious, spoke at a Monitor-hosted breakfast for reporters on Friday and gave several reasons for not calling for Mr. Holder’s resignation.

The first reason Issa cited was, “We haven’t reached all the conclusions that are appropriate in an investigation.” Issa also said he wanted to proceed cautiously given his panels “long reputation of jumping to the end result.” More importantly, Issa argued that the problems evident in the failed weapons operation go beyond problems caused by a single person.

“The fact is it is not about any one person. It is not about Eric Holder, it is not about [Assistant Attorney General] Lanny Breuer,” whose office signed off on the wiretaps for the operation, Issa said.

Instead, “it is about a failure that seems to be pervasive within [the Department of] Justice that investigations play fast and loose with the expectations of what is right or wrong when it comes to ... collateral damage. This isn’t the first time the FBI and other agencies have been involved in investigations in which bad people are allowed to continue doing bad things in the name of going after bad people,” Issa said.

According to the conservative website Daily Caller, some 52 members of the House and three Republican presidential candidates (Michele Bachmann, Rick Perry, and Jon Huntsman) have called on Holder to resign.

Holder has been criticized for testimony he gave to a House committee in May saying he had just recently learned about the gun-walking operation. Republicans cite a memo from the previous July that indicates the attorney general knew about the operation then.

Issa indicated that his patience with Holder was wearing thin. “I am asking for the president to stop having full confidence in Eric Holder unless Eric Holder can stop having full confidence in an array of people who are part of a problem that has not yet really been fixed. That is sort of a stay there and fix it, or go. But that is not for me to decide. It is for the president to decide,” he said.

The issue has apparently also tested Holder's patience. On Tuesday, he spoke sharply to a Daily Caller reporter who approached him after a White House event and asked about the calls for his resignation. “You guys need to – you need to stop this. It’s not an organic thing that’s just happening. You guys are behind it,” the publication quoted Holder as saying.