Tag Archives: statistics

Are you trying to justify your research submission to the EU or another funder?

One way that you can support your bid is to use the EU statistical database – Eurostat. The Eurostat website provides direct and free of charge online access to all its statistical databases and associated electronic publications. The Eurostat database is updated twice a day and covers:

the European Union

the EU Member States

the euro-zone

Candidate countries

EFTA countries

Take a look at the first visit page to find out the main features, including tools for visualisation of data, extraction tools, mobile apps and tutorials to help you make the best use of EU statistical data. You can register for free so that you can receive tailor-made e-mail alerts informing you of new publications as soon as they are online and access enhanced functionalities of the databases (customize the navigation tree, bulk download). You can also sign up to alerts. If you already have an ECAS login, you can access Eurostat using this.

At the Bournemouth University Clinical Research Unit (BUCRU) we think it is important to review our activities on a regular basis, to document our achievements and to outline our plans for the future. We have decided that the best way to do this is to prepare an Annual Report. It was completed some months ago and now we would like to share it more widely with our colleagues in the University. It can be found on our microsite at http://microsites.bournemouth.ac.uk/bucru/news/ we hope it is of interest.

The support and collaborations we offer are available to staff within the University, and to staff in the NHS. In the next year we will be particularly trying to develop new collaborations between University and health service staff that will lead to high quality grant applications.

We would like to invite you to an afternoon seminar by one of our Visiting Faculty, Professor Mike Wee, presenting some exciting new research findings to come out of a recently completed Research for Patient Benefit funded study comparing two methods of pain relief during labour (abstract and biography below). This paper was just voted best paper of the conference at the Obstetric Anaesthetists Association Annual Conference in Liverpool and was featured recently in the Bournemouth Echo http://www.bournemouthecho.co.uk/news/9770928.Pain_relief_in_labour__study_at_Poole_hospital_makes_important_discovery/

The seminar is scheduled for Thursday 19th July 2-3pm in BG10 Bournemouth House (after the HSC end of term lunch and next door for your convenience).

Background:Intramuscular pethidine, the commonest parenteral opioid analgesic used in obstetrics and more recently diamorphine usage has increased in the UK. The maternal, fetal and neonatal side effects are well known for pethidine but there are no sufficiently powered large RCTs comparing pethidine with diamorphine. The aim of this trial is to address this.

Methods: After ethical approval, informed consent was obtained from 484 women randomised to receive either 7.5mg diamorphine i.m. or 150mg pethidine i.m. for labour analgesia. The sample size calculation derived from a small RCT giving 90% power (at the 5% significance level) is based upon the maternal primary outcome measure of pain relief at 60mins and the neonatal primary outcome measures of Apgar Score of <7 at 1min and neonatal resuscitation. Secondary outcome measures include verbal pain intensity at 60mins and over 3hrs post-analgesia, pain relief over first 3hrs, maternal oxygen saturation, sedation, nausea and vomiting and maternal satisfaction with analgesia. Fetal and neonatal secondary outcomes include CTG trace, meconium staining, UApH, UVpH, time of delivery to first breath, Apgar Score at 5mins, naloxone use, neonatal oxygen saturations, sedation and feeding behaviour for the first 2hrs after delivery.

Results: Reported using CONSORT guidelines. At 60mins post-administration and over a 3hr period, diamorphine is better at reducing pain scores than pethidine (p<0.001). There were no statistical differences between the two groups regarding Apgar Scores of <7 at 1min and the need for neonatal resuscitation. The time between first dose administered and delivery is on average 82mins longer with the diamorphine group compared to pethidine (p<0.001). The vast majority of women experienced moderate to severe pain at all times. Women receiving diamorphine were more satisfied with their analgesia. There were no statistically significant differences in maternal sedation, nausea and vomiting or oxygen saturations over the 3hr period. There were no statistically significant differences in the fetal and neonatal outcomes including feeding behaviour between the two groups within 2hrs of birth but neonates in the pethidine group were more likely to be moderately or severely sedated at delivery.

Discussion: Intramuscular 7.5mg diamorphine gives significantly better analgesia than 150mg pethidine but prolongs delivery by approx. 82mins. Women given diamorphine are more likely to be satisfied with their analgesia. The mechanism for the prolongation of delivery time in the diamorphine group should be investigated further.

Acknowledgement: This research was funded by the NIHR Research for Patient Benefit Programme (PB-PG-0407-13170).

Michael Wee is a consultant anaesthetist from Poole Hospital and Royal Bournemouth Hospitals. He has a special interest in obstetric anaesthesia and is the lead obstetric anaesthetist at Poole Hospital. He is chair of the Research and Innovations Group at Poole Hospital and is a Board member of the Western Comprehensive Local Research Network. He was awarded a visiting professorship at Bournemouth University in 2009. He is a referee for several medical journals. His research interests include patient information, safety in anaesthesia, maternal analgesia and simulation in epidural anaesthesia. He is a co-supervisor of a PhD student at BU and chief investigator of the MObs study investigating early warning scores in obstetrics.

BUCRU has developed a consultancy service aimed at organisations that have an interest in health and wellbeing. Members of the team have many years experience of providing consultation services to the NHS, public bodies, charities and businesses. In addition to research projects we can also advise on audit projects, clinical evaluations, service evaluations and other areas where the collection and analysis of good quality data is important.

How can it help?

The service is flexible and tailored to the client’s requirements. Typically an initial meeting will involve finding out about the client’s needs and discussing the ways in which we can help. Our involvement could range from a single meeting to discuss a particular issue, through to conducting a project on behalf of the client.

In previous blogs we have described how BUCRU can help in developing grant applications. In this blog we describe some of the funded projects we are involved in.

BUCRU led research

Fatigue management in multiple sclerosis (MS): We have just completed a multi-centre randomised trial of a cognitive behavioural approach to fatigue management in people with multiple sclerosis1. This project was funded by the MS Society (http://www.mssociety.org.uk).

Improving activity and wellbeing in people with MS:We are just starting a MS Society funded pilot study to look at the Nintendo Wii home gaming system as a method of helping people with MS increase their activity levels and wellbeing.

Systematic review of psychological interventions for people with MS: A small grant to update our existing Cochrane review2

BUCRU collaborative projects

IDvIP: A National Institute for Health Research (NIHR) Research for Patient Benefit (RfPB) (http://www.ccf.nihr.ac.uk/RfPB/Pages/home.aspx) funded project. This is a multi-centre trial comparing 2 methods of pain relief for women in labour; diamorphine and pethidine3. The Chief Investigator is a Consultant in one of the local hospitals and a member of the Bournemouth University Visiting Faculty. BUCRU staff were involved in the design of the study, applying for the grant, data management, statistical analysis and interpretation, and advice on project management.*

WEIGHTED: A small grant from the College of Emergency Medicine held by a local Consultant/ member of the Visiting Faculty. This study is about to start and aims to develop a robust method of estimating the weight of patients attending a hospital emergency department. Many patients require a weight dependent dose of potentially life saving medication, but are too ill to be actually weighed. BUCRU were involved in designing the study and securing funding, and will be involved in ongoing advice on project and data management, statistical analysis and interpretation.

PEARLS: A large multi-centre trial of training maternity staff in assessing and repairing tears to the perineum acquired during labour and delievery4. This project is funded by the Health Foundation (http://www.health.org.uk) and run under the auspices of the Royal College of Midwives. BUCRU has been involved in data management, statistical analysis and interpretation.

PREVIEW: A pilot randomised trial comparing two methods of looking after tears to the perineum. The Chief Investigator is based in Birmingham, and the study is funded by the NIHR RfPB funding scheme. This study has recently started, and BUCRU was involved in the design of the study and the funding application. Further involvement will be in advising on project management, data management and statistical analysis.

Clinical Doctoral Research Fellowship: (http://www.nihrtcc.nhs.uk). Award held by BU and won by a radiographer based at the Anglo-European College of Chiropractic. The project involves tracking and measuring spinal motion. The research may have important implications in diagnosing people with chronic lower back pain. BUCRU were involved in the study design and funding application, and 2 members of staff are supervisors for her PhD.

BUCRU incorporates the Dorset Office of the National Institute for Health Research (NIHR) Research Design Service – South West (RDS-SW). This means that in addition to the support outlined in previous blogs, we can also provide access to the following:

RDS Grant application workshop.

This workshop is going to be held at Bournemouth University on the 29th February 2012 (http://www.rds-sw.nihr.ac.uk/grant_workshop.htm). Although the official deadline for applying has recently passed, it is worth contacting us to see if there are any remaining places. The workshop will also be held in other locations in the South-West region in the near future.

This is a one-day workshop for researchers who are developing proposals with the intention of applying for a grant. The workshop does not provide detailed training in research methodology; rather it more generally covers the full range of issues inherent in developing a successful grant application. It will be of relevance to researchers applying to any of the major health research funders, but particularly the NIHR funding schemes.

Researchers will need to send in advance the latest draft of their research proposal. As a minimum they should have a plan for a project but, ideally, a worked up proposal, perhaps even one that has been previously rejected. All proposals will receive detailed written feedback from the RDS team.

Topics include

The application as a marketing document, selling the topic, selling the method, and selling the team;

The balanced team;

Clarity of description and explanation;

Feasibility issues;

Identifying and avoiding potential pitfalls

RDS Residential Research Retreat

The Residential Research Retreat (http://www.rds-sw.nihr.ac.uk/rrr_home.htm) provides an opportunity for research teams to develop high quality health related research proposals suitable for submission to national peer-reviewed funding schemes. The aim of the Retreat is to provide the environment and support to promote rapid progress in developing proposals over a relatively short time period.

This Research Retreat is open to health professionals and academics working within the South West. Applications to attend the Retreat should be submitted by a team of three people with varied skills. Applications are reviewed competitively and places awarded to the most promising team proposals. The deadline for the next Research Retreat has passed, but it is anticipated that applications will be invited again later in the year.

At the retreat participants are supported by a range of experts while developing their research proposal. They work intensively on their proposal, while learning how to maximise its chances for successfully securing a grant.

In addition, the Residential Research Retreat helps participants develop the key skills needed to conduct research in a clinical setting as well as nurturing presentation skills and giving them the confidence to tackle research problems.

RDS Scientific Committee

The RDS Scientific Committee (http://www.rds-sw.nihr.ac.uk/scientific_committee.htm) provides an excellent opportunity for researchers in the south-west to obtain a critical review of a proposed grant application before it is sent to a funding body. The Committee brings the benefit of seeing the proposal with “fresh eyes”, replicating as far as possible the way the real funding committee will consider the application. Committee members include senior research consultants who have considerable experience of obtaining research funding, resulting in comprehensive comments and advice fed back.

Committee meetings take place approximately 9 times per year. To submit a study for review at the meeting, study paperwork must be provided to the Committee via BUCRU two weeks prior to the meeting date, and preferably a couple of months before the intended funding deadline.

Centre of Postgraduate Medical Research and Education (CoPMRE) Annual Symposium

In addition to events aimed at supporting the development of grant applications we also host an event geared towards dissemination. The CoPMRE Annual Symposium will be held on the 11th September 2012 at the Bournemouth University Talbot Campus. These successful annual conferences have been running for the past nine years and have featured themes such as ‘Professionalism and Collaboration’, ’Research Innovation’ and ‘Interprofessional Learning’. This year’s theme will be on using ‘Social media techniques in healthcare research and education’. The conference is open to all healthcare professionals and academics. More information will be posted on our website in due course and you will be able to register online nearer the time. For further information on the symposium please contact Audrey Dixon, Conference Manager (adixon@bournemouth.ac.uk ).

Contact us: For further information about, and access to, the Grant applications workshop, the Residential Research Retreat and the Scientific Committee please contact:

In today’s post we give a case study of how Bournemouth University Clinical Research Unit (BUCRU) recently supported the development of a grant application.

Case study

We recently supported a Programme Development Grant (www.ccf.nihr.ac.uk/PGfAR/PDG/Pages/default.aspx) application to the National Health Service (NHS) National Institute for Health Research (NIHR). The Unit receives funding from the NIHR to be the Dorset Office of the NIHR Research Design Service (RDS), and thus can support local researchers in the University and the NHS to develop their funding applications. The topic of this grant application was early warning systems for use in an obstetric setting. Early warning systems are used by clinical staff in hospital to identify clinical problems before they get too serious, for example by regularly monitoring vital signs such as blood pressure. The purpose of Programme Development Grants is to fund preliminary work ahead of a larger Programme Grant for Applied Research (PGAR; www.ccf.nihr.ac.uk/PGfAR/Pages/Home.aspx).

Patient and public involvement (PPI) – the team has a designated person supporting PPI.

Team development – a strong team needed to be developed with the appropriate skill mix to deliver the programme of research. Four members of BUCRU became co-applicants on the proposal bringing methodological expertise in systematic reviews, qualitative research, quantitative research, and PPI support. Via our link with the RDS we also have access to health economist support. Collaborations were initiated with the Wessex Health Innovation and Education Cluster (HIEC; www.wessexhiecpartnership.org.uk/) to gain support in the educational/ training aspects of the research.

Liaison – we liaised with a number of different organisations, such as Research and Knowledge Exchange Operations for costing the Bournemouth University (BU) costs, the NHS host organisation that will be responsible for the research, and the Market Research Group (MRG; https://mrg.bournemouth.ac.uk/) who were involved to support the administration and data entry for the survey component of the project.

Identification of appropriate funding schemes.

Obtained peer review from RDS colleagues across the region to provide feedback on the suitability of the funding scheme and the ‘readiness’ for submission. This service is usually provided through regular Scientific Committee meetings that act as ‘mock’ funding committees (www.rds-sw.nihr.ac.uk/scientific_committee.htm).

Quote from lead applicant: “Without the expertise and assistance of BUCRU staff it would not have been possible to even contemplate applying for a large and competitive grant such as the NIHR Programme Development Grant” .

In yesterday’s posting we gave a brief introduction to BUCRU. Today we introduce you to the members of the team.

Louise Ward

Louise is one of the administrators for the unit and has been with the team since 2008. She has worked in various NHS settings and has an interest in marketing. Both her undergraduate and Masters degrees were studied here at Bournemouth University.

Professor Paul Thompson

Paul is Consultant Rheumatologist at Poole Hospitaland Visiting Professor at BU. He was appointed Director of the Centre of Postgraduate Medical Research and Education (CoPMRE) in 2007, where he has been leading developments between research and education active doctors in NHS Trusts and the academic community at the University. He is Co-director of BUCRU, Lead for the musculoskeletal local priority group for the Western Comprehensive Local Research Network (CLRN) and Fellow of the NHS Improvement Faculty. He is interested in clinical research and service development in the rheumatic diseases. He supervises PhD students and is an External Examiner at other Universities.

Dr Sarah Thomas

Sarah is Deputy Director (methodology). She has a background in psychology and since 2000 has worked in the NHS in Dorset. As well as supporting other researchers in a Research Design Service capacity, she also conducts research. Her main research interests are in the field of multiple sclerosis (MS) and she is currently Chief Investigator for a pilot study funded by the UK MS Society exploring the use of the Nintendo Wii™ in people with MS.

Professor Peter Thomas

Peter is Co-Director and leads on research methodology. He has a background in epidemiology and statistics, and has been with Bournemouth University since 1996. He has a special research interest in psychosocial aspects of chronic disease and much of his recent work has focussed on multiple sclerosis.

Dr Zoe Sheppard

Zoe is a demographer with particular experience investigating socio-economic status. She joined Bournemouth University in October 2009 as a Research Fellow in Research Methods. She provides research methods support for people doing health research and support writing grant applications in her National Institute for Health Research (NIHR) Research Design Service (RDS) capacity.

Suzanne Sheppard

Suzanne is a Clinical Researcher recently recruited from the pharmaceutical industry to help manage the unit’s clinical trials. She has experience in setting-up and monitoring clinical trials across phases 1 to 3 in a variety of therapeutic areas.

Annabel Kenny

Annabel is a Clinical Research Administrator who joined Bournemouth University in October 2009. She provides support to Dr. Tamas Hickish, Consultant Medical Oncologist, Royal Bournemouth Hospital/Poole Hospital and the rest of the research team on various ongoing research projects within the Bournemouth University Clinical Research Unit.

Liz Griffiths

Liz works for the Royal Bournemouth Hospital as a research facilitator. She has been working in research within the NHS since 2003 in a variety of roles. Currently focusing on supporting researchers to develop proposals and prepare submissions to regulatory authorities.

Louise Fazakarley

Louise is a Physiotherapy lecturer with experience in neurological rehabilitation, the management of chronic disability and rehabilitation research. She joined Bournemouth University in 2006 to establish and teach on the BSc (Hons) Physiotherapy course. Louise is currently working on the MS Society funded pilot study to look at the Nintendo Wii™ as a method of helping people with MS increase their physical activity.

Audrey Dixon

Audrey is the Centre of Postgraduate Medical Research and Education (CoPMRE) co-ordinator and co-administrator for BUCRU. She has worked for the NHS since 1988. She first joined Professor Paul Thompson in 2001 to assist him with his academic work, following his secondment to the university. Audrey was seconded to BU in 2003. She now looks after a growing Visiting Faculty of 41 members and the education arm of CoPMRE. She is very proud to see the little acorn grow into a Centre of Postgraduate Medical Research and Education and BUCRU.

Roger Baker

Roger is Professor of Clinical Psychology and runs the MSc course Foundations in Clinical Psychology at BU. He is also a Consultant Clinical Psychologist at Dorset Healthcare University NHS Foundation Trust. He has expertise in the design of assessments and questionnaires, research design and clinical evaluation of services and has worked in a dual role as researcher and clinical psychologist at Leeds, Aberdeen & Bournemouth Universities and in NHS Trusts specialising in Mental Health.

Helen Allen

Helen is a health psychologist with a nursing and midwifery background. She has a qualitative background with a particular interest in the mind:body interface and chronic disease, including patient empowerment. She is the Unit lead on Public Patient Involvement.

This week the Bournemouth University Clinical Research Unit (BUCRU) will be posting daily blogs. In these blogs we will tell you a little about the Unit, what we do, who we are, and how we might be able to help in your research endeavours.

What is BUCRU?

BUCRU is a new model for supporting and conducting health related research in Dorset. It supports researchers in improving the quality, quantity and efficiency of research across the University and local National Health Service (NHS) Trusts. It does this by:

helping researchers with developing high quality applications for external research funding (including small grants)

ongoing involvement in funded research projects

a “pay-as-you-go” consultation service for other work

How can BUCRU help?

BUCRU can provide help in the following areas:

Study design

Quantitative and qualitative research methods

Statistics, data management and data analysis

Patient and public involvement in research

Trial management

Ethics, governance and other regulatory issues

Linking University and NHS researchers

BUCRU focuses on health research that has relevance to the NHS. The Unit is available to Bournemouth University staff and people working locally in the NHS. There are no general restrictions on topic area or professional background of the researcher. However we do have special interests in areas such as chronic disease and complex interventions (interventions in nursing, physiotherapy, occupational therapy, psychology and so on).

How is it funded?

BUCRU is partly funded by the National Institute for Health Research (NIHR) and incorporates the Dorset office of the NIHR Research Design Service (http://www.rds-sw.nihr.ac.uk). Further funding comes from a variety of research grants and contracts.

In 2010, through FP7, a whopping €3.9 billion of research funding was dished out. This was through 63 calls for proposals , where close to 2,600 proposals were selected – giving a success rate of almost 21%

Eurostat invites proposals for a range of tenders exploring statistics in relation to water use in developing countries, agro-agricultural land use, national statistical systems and energy. Funding is worth up to €100,000 over 12 months for water statistics projects, €10.7 million over 21 months for land use projects and €75,000 over 12 months for NSS research. For energy research up to €300,000 over 12 months is available, divided into three contracts, or up to €270,000 over 30 months, divided into three contracts, depending on the lot selected. View the full details for these calls by performing a Funding Search for 1162932, 1162933, 1162934 or 1162955 in the Full Text field.

Tenders submitted under EU Statistics should focus on income and living conditions methodological studies and publications; statistics on high-tec industries, knowledge-based services and human resources in science and tehcnology; statistics on innovation; patent statistics, with a focus on patenting by SMEs; methodological development of statistics on crime and criminal justice. The overall budget for this call is €1.75 million over 36 months and the deadline is 28.07.11.