Mineralocorticosteroid deficiency

Many adverse effects of licorice poisoning can be seen and most are attributed to the mineralocorticoid effects of GZA. Depending on the dose and intake of licorice, serious problems and even hospitalization can arise. People with previously existing heart or kidney problems may be more susceptible to GZA and licorice poisoning. [35] It is important to monitor the amount of licorice consumed in order to prevent toxicity. It is difficult to determine a safe level, due to many varying factors from person to person. In the most sensitive individuals, daily intake of about 100 mg GZA can cause problems. [39] This is equivalent to 50 g licorice sweets. However, in most people, they can consume up to 400 mg before experiencing symptoms, which would be about 200 g licorice sweets. A rule of thumb says a normal healthy person can consume 10 mg GZA a day. [40]

Fludrocortisone . Fludrocortisone is a mineralocorticosteroid that appears to be effective for most types of postural hypotension, or low blood pressure. It works by promoting sodium retention by the kidney , thereby causing fluid retention and some swelling , which is necessary to improve blood pressure. But this sodium retention also causes a loss of potassium. So when taking fludrocortisone, it's important to get adequate amounts of potassium each day. Fludrocortisone has none of the anti-inflammatory properties of cortisone or prednisolone and is not a muscle-building agent.