The Mortirolo Pass has featured several times in the Giro d'Italia, usually as the last or penultimate climb before the finish. The first time was in Stage 15 of the 1990 Giro d'Italia, between Morbegno and Aprica, starting from Edolo. Due to the steepness of the descent and the crashes that were occurring, the organisers decided to climb this mountain starting from Mazzo in subsequent years.[citation needed]

Since the death of Marco Pantani in 2004, stages of the Giro that go over the Mortirolo feature a special prize to the first man at the top of the pass, called Cima Pantani ("Pantani Top"). A monument to Marco Pantani was erected in 2006 by the Italian Professional Riders Association in the eighth kilometre of the road from Mazzo di Valtellina.
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