An AIDS-free generation is achievable. The approaches and interventions necessary are already available, and new methods in development will enable more people to take some control over their risk of infection. The fact that we dare hope of achieving it is a testimony to how far the effort to understand and tackle HIV/AIDS has come in the past 30 years. Nonetheless, ingenuity, equity, and multiparty engagement are needed to devise a clear roadmap to an AIDS-free generation.