The Destabilized Fluorescent Protein Vectors are promoterless vectors that encode rapidly degraded forms of ZsGreen1, DsRed-Express, and HcRed1. They include a portion of the mouse ornithine decarboxylase (MODC) gene, fused to the downstream end of the gene for the fluorescent protein. This region of MODC contains a PEST domain that targets the pFP-DR fusion protein for degradation, giving it a substantially shorter half-life (1). These destabilized variants can be used in cells from any organism that employs PEST sequence-mediated degradation pathways.

As with other fluorescent proteins, the pFP-DR vectors are human codon-optimized and retain the same spectral properties as our standard fluorescent proteins. Destabilized fluorescent proteins can be easily and immediately visualized by fluorescence microscopy or analyzed by flow cytometry.

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