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8:42 p.m. | Updated The litany of public misbehavior involving the actor Charlie Sheen took a dramatic turn Thursday, when the star of the hit CBS comedy “Two and Half Men” denounced the creator of the show, Chuck Lorre, and in response, production of the show was halted.

In January, Mr. Sheen’s most recent bout of excesses tied to drugs and alcohol resulted in an announcement that he was entering rehabilitation and forced the show to suspend production and cancel four episodes. On Thursday, he called in as a guest on a syndicated radio show hosted by Alex Jones. Later, he granted an interview to the celebrity gossip Web site TMZ.

In both, Mr. Sheen went on rants about Mr. Lorre, the executive producer of “Two and a Half Men,” assailing him as “clown” and a “charlatan” whose “tin can” of a show Mr. Sheen said he had converted into “pure gold.”

In a terse statement, CBS and Warner Brothers, which produces the comedy, said, “Based on the totality of Charlie Sheen’s statements, conduct and condition, CBS and Warner Bros. Television have decided to discontinue production of “Two and a Half Men” for the remainder of the season.”

The interviews Thursday became the latest in a long litany of egregious behavior by Mr. Sheen, characterized by numerous incidents involving drugs, alcohol, and women.

The network and the studio, which had tolerated most of those episodes because Mr. Sheen mostly managed to show up in time for work (the show shut down production twice in the past two years to provide Mr. Sheen an opportunity to go into rehab) acted after the interviews Thursday.

Mr. Lorre, one of the most successful producers of television series in network history, has created two other comedies that are hits on the CBS schedule, “The Big Bang Theory” and “Mike and Molly.”

In both interviews, Mr. Sheen said Mr. Lorre’s real name is “Chaim Levine.” He was born Charles Levine; the Hebrew name is Chaim.

In a previous radio appearance on ESPN, Mr. Sheen had indicated he was ready to go back to work, but was being prevented by the decision to shut down production. In the interviews Thursday, he said Mr. Lorre was not doing “his job, which is to write,” and he accused Mr. Lorre of taking money away from him by canceling several episodes of the show. Mr. Sheen makes a reported $1.2 million an episode.

Beyond the attacks on Mr. Lorre, Mr. Sheen dismissed the notion that he needed help for his chemical dependencies, saying he had cured himself “in a nanosecond.”

Mr. Sheen, who had promised to enter rehab after a trip to the hospital following a night of partying, later said he would only undergo treatment at his home. In the radio interview, he also denigrated the women whom have been in the middle of several of his misadventures.

Mr. Lorre declined to comment.

Mr. Sheen’s behavior has not previously risen to a level where those entities have felt compelled to take steps to either fire him or replace him, largely because he has also managed to show up for work as scheduled.

In January, Nina Tassler, the president of CBS Entertainment, expressed concern about Mr. Sheen’s behavior, but said, “On a professional level he does his job, he does it well and that’s all I really have to say.”

CBS and Warner Bros. Television announced Thursday that they are stopping production of TV's top-rated comedy, "Two and a Half Men," following star Charlie Sheen's rants against show creator Chuck Lorre.

Here's the full announcement:

Statement from CBS Entertainment and Warner Bros. Television

Based on the totality of Charlie Sheen’s statements, conduct and condition, CBS and Warner Bros. Television have decided to discontinue production of “Two and a Half Men” for the remainder of the season.

"I embarrassed him in front of his children and the world by healing at a pace that this un-evolved mind cannot process. I've spent, I think, close to the last decade I don't know effortlessly and magically converted your tin can into pure gold. And the gratitude I get is this charlatan chose not to do his job, which is to write."

"I gracefully ignored this folly for 177 shows ... I fire back once and this contaminated little maggot can't handle my power and can't handle the truth."

"I wish him nothing but pain in his silly travels especially if they wind up in my octagon. Clearly I have defeated this earthworm with my words -- imagine what I would have done with my fire breathing fists."

The show may never come back with the things Sheen said about his boss. Ohh I sure hope Chuck Lorre holds a grudge LOL

I like you….I really do! From Wall Street to Cadence to Hot Shots, hell Hot Shots Part Deux, you’ve always had a special place in my heart. Furthermore, you have one of the most talented and intense actors of all time as a father, the awesome Martin Sheen!

Because I like you so much, I tried to downplay all the nuttiness but this time, you’ve gone too far….and that disappoints me. Do you have any idea how many out-of-work actors would kill to be in your shoes right now? Shoot, I’m sure your brother Emilio would take over your role if offered, he hasn’t been in anything since The Mighty Ducks #25! When you’re blessed with such talent and willingly choose to piss/puree/Nazi-stomp on it all for the sake of drugs and pussy, it eventually becomes hard for fans to feel sorry for you. Sadly to say, I’m now at that point.

Do yourself a favor; listen to your family and friends and go back to rehab, clean up and beg Chaim/Haim/Ira Levine’s forgiveness…then beg the rest of the cast and crew for their forgiveness. More importantly, think of your beautiful daughters and do right by them. Otherwise, I’ll be watching your obit on ET, Extra, CNN, etc.