Can cerebral lymphomas and glioblastomas be differentiated based on histogram parameters on contrast-enhanced T1-weighted images?

Tatsuya Yamamoto1, Yuriko Ohtani2, and Hirohiko Kimura1

1Department of Radiology, University of Fukui, Fukui, Japan, 2Division of Radiology, University of Fukui Hospital, Fukui, Japan

Cerebral
lymphomas are sometimes difficult to distinguish from glioblastomas based on
routine magnetic resonance (MR) examination. Therefore, this study assessed the
utility of a histogram analysis of the intratumoral enhanced region, using
contrast-enhanced T1WI (CET1WI) with a 3D-spoiled gradient recalled aquisition in the steady state (SPGR) sequence, for cerebral lymphomas
and glioblastomas, to determine whether the histogram parameters differed
between the two tumors. There was significant difference (p < 0.01) in skewness between lymphomas and glioblastomas. This
suggests the possibility of differential diagnosis of cerebral lymphomas and
glioblastomas by histogram analysis of CET1WI.

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