“The first time I hosted ‘Saturday Night Live,’ it was such a big deal for me, I think my immune system just like broke down, so I got the flu or something,” the 39-year-old said. “So … maybe it’s something that happens to me when I get nervous … but I get through it …because that adrenaline rush.”

It will not only be Fallon’s first night as the late night talk show’s host, but it’s also the first time in more than 40 years since the show had taped from New York City. Johnny Carson moved the show from New York to Burbank in 1972.