Genelia was born on August 5, 1987, in England. She completed his schooling at Apostolic Carmel High School in Bandra, Mumbai. After that, she joined at St. Andrews College, Bandra to pursue a Bachelor's Degree. Her father is a senior official with TCS. Her mother was a managing director with a Pharma Multinational corporation, but she left her job to help her in his carrer.

Genny is her nick name. She was a sports player won many prizes. Genelia D'Souza was state level athlete, sprinter, and a national level football player.