Pathologically confirmed diagnosis of a solid tumor for which no standard therapy proven to provide clinical benefit is available.

≥18 years of age

Life expectancy of at least 3 months.

ECOG performance status of 0 to 2.

Ability to follow the study and all protocol requirements.

Voluntarily sign an informed consent form

Women of child-bearing potential (WCBP), defined as a sexually mature woman who has not undergone a hysterectomy or tubal ligation of who has not been naturally postmenopausal for at least 24 consecutive months, must have a negative serum or urine pregnancy test prior to treatment. All WCBP, all sexually active male patients, and all partners of patients must agree to use adequate methods of birth control throughout the study.

Recovery to </= Grade 1 or baseline of any toxicities due to prior treatments, excluding alopecia.

Any tyrosine kinase inhibitor (e.g. erlotinib, imatinib) within 2 weeks of the start of IPI-926 administration

Nitrosoureas o or mitomycin C within 6 weeks of the start of IPI-926 administration.

Inadequate hematologic function - neutrophil count (ANC) <1,500 cells/mm3, platelet count <100,000/mm3, or hemoglobin <9.0 g/dL (may be increased to this level with transfusion as long as there is no evidence of active bleeding).

History of stroke, unstable angina, myocardial infarction, or ventricular arrhythmia requiring medication or mechanical control within the last 6 months.

Venous thromboembolic event (e.g. pulmonary embolism or deep vein thrombosis) requiring anticoagulation or who meet any of the following criteria are excluded:

have been on a stable dose of anticoagulation for <1 month

have had a Grade 2, 3 or 4 hemorrhage in the last 30 days

experiencing continued symptoms from venous thromboembolic event (e.g. continued dyspnea or oxygen requirement) *Past venous thromboembolic event but do not meet any of the above three criteria are eligible for participation.

History of a seizure within the last 10 years or seizure disorder requiring anti-epileptic medications.

Concurrent treatment with medications known to lower the seizure threshold.

Concurrent administration of the medications or foods which are known to inhibit or induce CYP3A activity to a clinically relevant degree.

Presence of active infection or systemic use of antibiotics within 72 hours of treatment.

Significant co-morbid condition or disease which in the judgment of the Investigator would place the patient at undue risk or interfere with the study.

Known immunodeficiency virus (HIV) positivity.

Pregnant or lactating women.

Contacts and Locations

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study.
To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below.
For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00761696