What They Are Prescribed For

Help certain people decrease their risk of cardiovascular disease (CVD),
stroke
, and death if used along with diet and exercise

Lower total cholesterol

Lower LDL-cholesterol (bad cholesterol)

Raise HDL-cholesterol (good cholesterol)

Lower triglycerides

Lower C-reactive protein levels—a marker of inflammation, which is thought to increase risk of CVD

Although some people can attain their goals with diet and exercise alone, statins may be prescribed based on your overall risk of having a
heart attack
or stroke in the next 10 years. Communication is an important aspect of your care. If you have questions or concerns about taking medications when your cholesterol numbers are on target, talk to your doctor about them.

How Statins Work

Statins block an enzyme in the liver (HMG-CoA reductase) that produces cholesterol. They are particularly effective at reducing LDL-cholesterol.

Precautions While Using These Medications

See Your Doctor Regularly

It is important that your doctor check your progress. Regular visits will allow for dosage adjustments and to help monitor for any side effects.

Avoid Pregnancy

Statins should not be taken during pregnancy. Cholesterol production is essential for normal fetal development. Statins decrease cholesterol production and therefore may cause birth defects. Women who are able to become pregnant should use birth control while taking a statin drug. Tell your doctor if you think you might be pregnant or you are considering becoming pregnant. Also tell your doctor if you are breastfeeding, as statins may cause problems for a nursing baby.

Control Your Weight

If you are overweight or
obese
, losing weight may help decrease the need for or amount of medication. Check with your doctor about this.

Manage Your Medications

Tell your doctor about all the medications you take. Some medications should not be taken with statins, while others may require a different dosage level. Examples of these include:

Antifungals, such as fluconazole,
itraconazole,
or ketoconazole

Immunosuppresants, such as cyclosporine

Digoxin—some statins may increase blood levels of digoxin, increasing the risk of side effects

Macrolide antibiotics, such as erythromycin or clarithromycin

Fibric acid derivatives, such as gemfibrozil

Niacin
or nicotinic acid—use of this type of medication with a statin may increase the risk of developing muscle problems

Oral contraceptives/birth control pills—some statin drugs may increase the blood levels of the hormones in birth control pills, increasing the risk of side effects

Antidepressants, such as nefazodone

Talk to your doctor about the medications that you take and whether there could be an interaction with the statin.

Be Cautious With Certain Conditions

The presence of other medical problems may affect the use of statins. Tell your doctor if you have any other medical problems, especially:

Recent major surgery or
trauma
, which may increase the risk of problems that may lead to kidney failure

Impending surgery, including dental surgery or emergency treatment—be sure to tell the doctor or dentist treating you that you are taking a statin drug

Avoid Excessive Alcohol

Excessive amounts of alcohol combined with statin drugs can have bad affects on the liver. Moderation in alcohol consumption is generally defined as one drink per day for women and two drinks per day for men.

Avoid Grapefruit Juice

Grapefruit juice appears to interfere with the metabolism of most statin drugs. It is best to avoid it during treatment.

Do Not Stop On Your Own

Do not stop taking your statin medication without first checking with your doctor. When you stop, your cholesterol levels may increase, and your doctor may want to use other ways to keep cholesterol levels within a more desirable range.

Mind Your Meals with Lovastatin

Lovastatin works better when it is taken with food. If you are taking lovastatin once a day, take it with the evening meal. If you are taking more than one dose a day, take each dose with a meal or snack.

If you are taking another kind of statin, ask the pharmacist if you need to take it with food.

Missed Dose

If you miss a dose of your statin drug, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Avoid double doses.

Possible Side Effects

Statin drugs are generally considered safe and few people need to discontinue them due to adverse effects. The side effects listed here have been reported for at least one of the statins, not necessarily all of them. However, since many of the effects of statins are similar, it is possible that these side affects may occur with any one of these medications, although they may be more common with some than with others.

Adverse Effects

The most significant adverse effects, though rare, involve the liver (elevated liver enzymes) and the muscles (different conditions called myopathy and
rhabdomyolysis
).

Other potential adverse effects include changes in mental status, such as memory loss and confusion, and increased blood glucose levels.

Go to any follow-up appointments recommended by your doctor. Statins and their side effects can be monitored. If needed, your dosage or medication may be changed.

This content is reviewed regularly and is updated when new and relevant evidence is made available. This information is neither intended nor implied to be a substitute for professional medical advice. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with questions regarding a medical condition.