Usually said simply as Cyanide and Happiness, and sometimes misspelled "Cynaide and Happiness", a webcomic hosted at explosm.net. Recurring themes involve necrophilia, rape, illness (Cancer, AIDS), pedophilia, and poking fun and Christianity's Jesus of Nazareth (All in good fun, of course). Recurring "characters" include "LOL Fag!" man, Punchline Spoiler man, et cetra. The series (with updates every day, on most occasions) is most prominent for its black comedy.

Cyanide & Happiness happens to be the only webcomic I really find amusing; opinions vary, of course.