• vacuolized lysosomes were evident in the livers of homozygous fetuses at 19 days, whereas only few, small vacuoles were detectable in fetuses of 14 days; in contrast, cells in brain sections of 19 day fetuses showed only scanty small vacuoles, whereas in 6-week-old mice the vacuolization in brain cells was extensive

• the diameter of storage lysosomes varied from 0.2 to 4 m in most organs, and up to 8 m in the liver

• in brain, lysosomal storage vacuoles were detected in the neurons and glia of the neocortical and cortical regions