For most men, testosterone levels peak in their adolescence and early adulthood. Testosterone levels gradually decrease in men during their 30s or 40s. Some men suffer from low testosterone, or low-T. This is also called hypogonadism. It is important to differentiate between hypogonadism and normal aging. Hypogonadism can include the following symptoms:

Decreased sex drive

Less frequent sexual activity

Weaker erections or decreased potency

Depressed mood

Irritability

Decreased energy

Decreased strength or muscle mass

Increased body fat

Decreased bone density

Testosterone Replacement Therapy (TRT) is FDA-approved for the treatment of men with hypogonadism. This comes in different forms.

Lotion/gel

Injection

Pellet

Patch

It is unclear if TRT is related to increased cardiovascular disease in men. Scientific research has shown conflicting evidence, and more studies are needed. The FDA is studying the risk of heart attack, stroke, and death in men on TRT. Risks of TRT include the following:

Breast swelling/tenderness

Elevated red blood cell count

Small testicles

Acne

Ankle or foot swelling

Infertility

TRT should only be used for men with symptomatic hypogonadism. Men on TRT require regular checkups and blood tests. Ask your doctor if testosterone replacement is right for you.