The series is executive produced by Adam Greener, Jim Sayer, and Stephanie Chambers.[4] Maverick TV and All3Media America are the production companies behind the series.[5] On April 14, 2014, the USA Network ordered a 12-episode second season of Chrisley Knows Best.[6] It is also USA Network's youngest-skewing[clarification needed] original series.[6] On October 20, 2014, the series was renewed for a 12-episode third season.[7] On February 5, 2015, the episode order was increased by six episodes for a total of 18 for season 3.[8] On July 7, 2016, USA renewed the show for a fifth season. That same day, the network announced that the second half of season 4 will premiere in August bringing it to a total of 26 episodes. On July 25, 2017, a sixth season was picked up of Chrisley Knows Best, and on that same day it was confirmed that Season 5 will start back airing on September 12, 2017, and a sixth season will begin filming in November 2017. On October 31, 2018 USA Network has renewed its flagship reality docuseries Chrisley Knows Best for a seventh season and greenlit a 16-episode spinoff Growing Up Chrisley, both for premiere in 2019.

The show has received mixed reviews. Tom Gliatto of People gave the show a rating of 75% and gave a positive review, saying "This is the best 'family' reality series since Honey Boo Boo or even The Osbournes from several eons ago". Hillary Busis of Entertainment Weekly gave a mixed review, saying "If you can get past the canned lines and sub-sitcom storylines, the Chrisley crew can be fun".[109] Brian Lowry of Variety gave a mixed review, saying "As intriguing in the details as it is uncomfortable to watch, 'Chrisley Knows Best,' a self-consciously sitcom-like reality show, initially seems to be just another knock-off designed to cash in on the 'Duck Dynasty' demo. Cut through the deep-fried window dressing, though, and this USA series is almost entirely devoted to its subtext, intended to elicit sniggering regarding that which goes unsaid about the show’s wealthy father of five, whom his son-in-law understatedly dubs 'flamboyant.' Played as epic farce, the skein should have a disparate range of appeal, but let’s hope the Chrisleys don’t mind being laughed at, not with."[110]