Narrator: You are a traveller... (point-of-view visual of an individual’s legs relaxing by a pool-side).

Narrator: ...and you are already dreaming of your next getaway. (individual jumps into the pool and the water is labelled with: Pool water contaminated with Hep A).

Disclaimer on-screen reads: TWINRIX is a combined hepatitis A and hepatitis B vaccine used in adults, adolescents, children, and infants over the age of 1 year to prevent hepatitis A and hepatitis B diseases

Narrator: While your travel plans probably dont include hepatitis A or hepatitis B... (close up of table with hot food, vegetables and fruits, which is labelled with: Food contaminated with Hep A).

Disclaimer reads: 100% protection cannot be guaranteed and booster doses may be required.

Narrator: ...you know that many common travel activities can put you at risk of acquiring these two serious liver diseases... (close up of a tray of mixed drinks being served and labelled with: Crushed ice contaminated with Hep A).

Disclaimer reads: TWINRIX does not protect against hepatitis C or E, and is not indicated to treat or reduce the severity of hepatitis A or B infections. (Close up of a table with spa tools with label reading: Spa tools contaminated with Hep B).

Narrator: ...which is why you plan on talking to your doctor about TWINRIX, right? ... Of course, right...(thumbs up) ...because you are a traveller.

Video concludes with TWINRIX logo, GSK logo, You are a traveller slogan, and safety information: Very commonly (more than 10% of doses) reported adverse events in adults were pain or discomfort, redness at the infection site, headache, and tiredness. Common (between 1% and 10% of doses) adverse events were swelling at the injection site, diarrhea, nausea and vomiting, and generally feeling unwell. Allergic reactions may also occur. Full product information can be found on Twinrix.ca. If you need to report an adverse event, please call 1-800-387-7374.

A doctor stands in a blank white room and says, Hey, Traveller! Hold up!. He runs off of the right side of the screen, quickly re-appears, and introduces himself: Hi. Im Doctor David Willer. His full title appears: Dr. David Willer, PhD. Global Scientific Affairs Lead, GSK.

Dr. Willer continues with, "I heard you may be planning a Caribbean vacation. Sounds great! Heres some food for thought before you go. Youve probably heard about some of the travel activities that can put you at risk for hepatitis A and B. But there are others that might surprise you. The hepatitis A and B viruses are endemic, or commonly present, throughout the Caribbean. You can even be at risk at a 5-star resort."

Dr. Willer walks forward, which reveals a table with fruit, an ice bucket, mixed drinks, and a cloche. He says, "Hepatitis A spreads when human waste contaminates food or drinks, usually through water. For example, fresh fruit and vegetables might be rinsed in contaminated water."

A close-up of the table pans across screen, individually displaying the fruit, ice bucket, mixed drinks, and cloche, while Dr. Willer says, "Or your food and drinks can be contaminated by a restaurant worker whos infected and hasnt washed their hands."

Dr. Willer re-appears, saying, "The virus can even make its way into crushed ice used in mixed bar drinks or blended into a smoothie."

Dr. Willer reaches for the cloche to lift the cover and says, "And it may surprise you to find out...that your resort pool water can be contaminated with hepatitis A." After lifting the cover, it reveals pool toys.

The video then cuts to Dr. Willer sitting on a wicker arm chair with a trolley of spa and salon tools next to him. He says, Its important to know that you can be infected with hepatitis A and not experience any symptoms... Text appears: TWINRIX is not indicated to treat the symptoms of hepatitis A.

Dr. Willer continues, ...Which means you could unknowingly spread the virus to others. Now, the hepatitis B virus is different. It spreads through contact with infected bodily fluids such as blood, saliva, or other secretions.

A close up of spa tools is displayed while Dr. Willer states, "The virus can live on surfaces such as spa and salon tools for up to seven days!

Dr. Willer re-appears saying,A spa tool might be cleaned but not properly sterilized. So even a shiny tool could be contaminated with the virus. He reaches out to the trolley and picks up the scissors and states, Or one small nick made by contaminated scissors, clippers, or a razor, could spread the disease.

Video cuts to Dr. Willer standing again, saying, Hepatitis B can also survive on medical equipment thats been cleaned and reused instead of being properly discarded. Imagine youre at the beach. A cut from a sharp stone could put you at risk if unsterilized tools are used to stitch your wound... (Dr. Willer holds up a syringe) or inject pain medication. While most patients recover from a hepatitis B infection, about five to ten percent become lifelong carriers. If this happens, you can pass the virus on to others for the rest of your life without having symptoms yourself... Text appears: TWINRIX is not indicated to treat the symptoms of or reduce the serious consequences associated with hepatitis B. Dr. Willer continues, ...And this chronic carrier state may lead to cirrhosis and liver cancer.

Video cuts to Dr. Willer standing next to a table with spa tools, fruit, ice bucket, and pool toys. He says, Like you, I love to travel. In fact, I feel strongly that travel is an important part of maintaining our overall wellbeing. But many of the things we enjoy the most about resorts can put us at risk for hepatitis A and B. Trying to avoid them all would be difficult... to say the least. But you can protect yourself and your family with vaccination. Its the best way to prevent infection. So before you travel, talk to your doctor or pharmacist about vaccination against hepatitis A and B, and ask if TWINRIX is right for you.

Video concludes with Twinrix logo, followed by safety and legal information: TWINRIX is a vaccine used in adults, adolescents, children and infants to prevent hepatitis A and B diseases. 100% protection cannot be guaranteed and additional doses may be required. Very common adverse events (>10% of doses) reported in adults, were pain or discomfort, redness at the infection site, headache, and tiredness. Common adverse events (1% to 10% of doses) were swelling at the injection site, diarrhea, nausea and vomiting, and generally feeling unwell. Allergic reactions may also occur. Vaccination may not be suitable for everyone, so ask your healthcare professional if TWINRIX is right for you. Full product information can be found on Twinrix.ca. To report an adverse event, please call 1-800-387-7374.

A doctor sits on a wicker arm chair and says, Hey, Traveller! I hear youre heading south for some fun in the sun. Sounds great! Im Doctor Heather VanSeggelen. Her full title appears: Dr. Heather VanSeggelen, PhD. Scientific Advisor, GSK.

She continues, Are you wondering if your resort destination is a risk for hepatitis A and B? Well, if youre headed to the Caribbean, the answer is yes! Dr. VanSeggelen catches a beach ball that is decorated as a globe. Dr. VanSeggelen says, Hepatitis A and B are endemic - that means commonly present at many popular travel destinations like the Caribbean (Displays close-up of the Caribbean on the globe).

You can even be at risk at a 5-star resort. Dr. VanSeggelen says and throws back the globe beach ball. She continues, Now, theres a misconception that hepatitis A and B are only a threat if youre off the resort doing risky activities. But you can be exposed to these two serious liver diseases without ever leaving your resort. Let me tell you how.

A bowl of fruit is displayed next to Dr. VanSeggelen and she states, Hepatitis A and B viruses have different ways of spreading. Video cuts to close-up of the bowl of fruit, followed by a tray of mixed drinks, and finally pool toys, while she states, You can get infected with hepatitis A through food, your favourite iced drink, even the pool water.

Dr. VanSeggelen re-appears, saying, So you might see why in recent years forty percent of hepatitis A cases in Canada have been travel-related. Its also important to remember that you can be infected by hepatitis A and not have any symptoms…” Text appears: TWINRIX is not indicated to treat the symptoms of hepatitis A. Dr. VanSeggelen continues, ...Which means you could unknowingly spread the virus to others. Now, the hepatitis B virus is different. It spreads through contact with infected bodily fluids such as blood, saliva, or other secretions. Travelling to the Caribbean may expose you to all of these in ways that might surprise you.

Video cuts to Dr. VanSeggelen sitting on a wicker arm chair with a trolley of spa and salon tools next to her. She says, For example, I cant think of anything more relaxing than a manicure or a pedicure at a resort spa. But you can get infected with hepatitis B through improperly sterilized equipment... Video cuts to close-up of spa tools displayed while Dr. VanSeggelen continues with, ...such as spa tools, salon tools used for cutting hair or shaving, even first aid equipment like suture needles or syringes.

Dr. VanSeggelen stands again and states, While most patients recover from a hepatitis B infection, about five to ten percent become lifelong carriers. Which may lead to cirrhosis or liver cancer. Text appears: TWINRIX is not indicated to treat the symptoms of or reduce the serious consequences associated with hepatitis B.

Dr. VanSeggelen continues, So how do you help keep hepatitis A and B out of your Caribbean vacation plans? The best way to prevent infection is vaccination. So before you travel, see your doctor or pharmacist about vaccination against hepatitis A and B, and ask if TWINRIX is right for you.

Video concludes with TWINRIX logo, followed by safety and legal information: Twinrix is a vaccine used in adults, adolescents, children and infants to prevent hepatitis A and B diseases. 100% protection cannot be guaranteed and additional doses may be required. Very common adverse events (>10% of doses) reported in adults, were pain or discomfort, redness at the infection site, headache, and tiredness. Common adverse events (1% to 10% of doses) were swelling at the injection site, diarrhea, nausea and vomiting, and generally feeling unwell. Allergic reactions may also occur. Vaccination may not be suitable for everyone, so ask your healthcare professional if TWINRIX is right for you. Full product information can be found on Twinrix.ca. To report an adverse event, please call 1-800-387-7374.

TWINRIX is a vaccine used in adults, adolescents, children and infants to prevent hepatitis A and B diseases. 100% protection cannot be guaranteed and additional doses may be required. Very common adverse events (>10% of doses) reported in adults were pain or discomfort, redness at the injection site, headache, and tiredness. Common adverse events (1% to 10% of doses) were swelling at the injection site, diarrhea, nausea and vomiting, and generally feeling unwell. Very common adverse events (>10% of doses) reported in children were pain and redness at the injection site. Common adverse events (1% to 10% of doses) were swelling at the injection site, fever (more than 37.5°C), irritability, drowsiness, headache, loss of appetite, diarrhea, nausea and vomiting, and generally feeling unwell. Allergic reactions may also occur. Vaccination may not be suitable for everyone, so ask your healthcare professional if TWINRIX is right for you. Full product information can be found on Twinrix.ca. To report an adverse event, please call 1-800-387-7374.

This site does not provide medical advice. The contents of this site are for information purposes only and are not in any way intended to replace or substitute the advice of your healthcare professional. This site is intended for use by Canadian residents only.

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Although GlaxoSmithKline Inc. offers, as a convenience, links to a number of websites that we believe may offer useful information to our visitors ("Linked Sites"), GlaxoSmithKline Inc. makes no warranty of any kind regarding the accuracy and use of the information on these Linked Sites and is not liable for damages of any kind arising out of your access to, or use of, these Linked Sites. The privacy policies, legal information and procedures described on the GlaxoSmithKline Inc. website do not apply to Linked Sites. You must contact these Linked Sites directly for information on their data collection and distribution policies. Your use of and browsing in Linked Sites are at your own risk.

TWINRIX Supply Update

TWINRIX and TWINRIX Junior continue to be available in Canada; however, supply of one or both formulations is currently limited. In the event TWINRIX and/or TWINRIX Junior is not available at your preferred pharmacy or vaccination clinic, it is recommended that you contact alternate locations. For additional information on supply, please check the Drug Shortages Canada website at http://www.drugshortagescanada.ca/.