Born under unusual circumstances, Benjamin Button (Brad Pitt) springs into being as an elderly man in a New Orleans nursing home and ages in reverse. Twelve years after his birth, he meets Daisy, a child who flickers in and out of his life as she grows up to be a dancer (Cate Blanchett). Though he has all sorts of unusual adventures over the course of his life, it is his relationship with Daisy, and the hope that they will come together at the right time, that drives Benjamin forward.

When a disc containing memoirs of a former CIA analyst (John Malkovich) falls into the hands of Linda Litzke (Frances McDormand) and Chad Feldheimer (Brad Pitt), the two gym employees see a chance to make enough money for her to have life-changing cosmetic surgery. Predictably, events whirl out of control for the duo doofuses and those in their orbit.

Former prosecutor Michael Clayton (George Clooney) works as a "fixer" at the corporate law firm of Kenner, Bach and Ledeen, and takes care of his employer's dirty work. Burned out and deep in debt, he is bound tightly to the firm. Clayton faces the biggest challenge of his career when a guilt-ridden attorney (Tom Wilkinson) has a breakdown during a huge class-action lawsuit.