Use this page as a resource to start your research on the uses of, studied and reported health benefits of CBD.

Parkinson’s disease is a progressive nervous system disorder that affects nearly 1 million people in the U.S. Studies have shown marijuana can slow the disease’s progression and help patients manage the disease’s associated symptoms.

Overview of Parkinson’s Disease

Parkinson’s disease is a chronic, progressive disorder of the nervous system that causes the malfunction and death of nerve cells in the brain. Parkinson’s disease (PD) typically starts with a minor tremor and develops gradually, eventually causing stiffness throughout the body and slowing movement. Some neurons produce dopamine, a chemical that sends messages to the part of the brain that controls movement, and as these neurons die from Parkinson’s disease, the amount of dopamine decreases and movement is subsequently affected.

While the cause of Parkinson’s disease is unknown, genes and environmental triggers likely play a role. Specific genetic mutations have been identified and having a close relative with Parkinson’s increases chances of developing the disease. Exposure to certain toxins like herbicides and pesticides could also increase risk.

Symptoms associated with Parkinson’s disease include tremors, bradykinesia (slowness of movement), rigidity (stiffness) and postural instability. Tremors can occur in the hands, arms, legs, jaw and face. Parkinson’s disease is also commonly accompanied with depression, cognitive problems, swallowing problems, sleep problems, fatigue and pain. Psychosis, a severe impairment in thinking and emotion that causes one to lose contact with reality, can also occur.

There is no cure for Parkinson’s disease. However, treatments can help to improve symptoms. Medications can be used to help manage walking, movement and tremor problems by increasing or substituting for dopamine. Surgery may eventually be required to regulate certain regions of the brain.

Findings: Effects of Cannabis on Parkinson’s Disease

Evidence suggests that cannabis could potentially slow the progression of Parkinson’s by providing neuroprotective effects. The cannabinoids found in cannabis are able to suppress excitotoxicity, glial activation and oxidative injury that cause the degeneration of the dopamine-releasing neurons. In addition, they improve the function of cell’s mitochondria and activation of cellular debris clearance, further encouraging neuron health (More & Choi, 2015) (Garcia-Arencibia, Garcia & Fernandez-Ruiz, 2009) (Lastres-Becker & Fernandez-Ruiz, 2006) (Zeissler, et al., 2013). Researchers have found evidence that one specific cannabinoid found in cannabis, tetrahydrocannabinol (THC), helps in the treatment of Parkinson’s disease by assisting in the prevention of damage caused by free radicals and activating a receptor that encourages the formation of new mitochondria (Zeissler, et al., 2013). Another major cannabinoid found in cannabis, cannabidiol (CBD), has also demonstrated its ability to support the health of neural cells mitochondria, causing the researchers concluded that CBD should be considered as a potential therapeutic option in neurodegenerative disorders like Parkinson’s because of its neuroprotective properties (da Silva, et al., 2014) (Zuardi, 2008).

Significant improvements in well-being and quality of life scores were found in Parkinson’s disease patients that were given daily doses of CBD for one week (Chagas, et al., 2014). One case study found that patients treated with CBD, though they didn’t see significant improvements in motor measures or general symptoms, experienced prompt and substantial reductions in the frequency of REM sleep behavior disorder events (Chagas, et al., 2014). In one survey, despite only 4.3% of Parkinson’s disease patients responding that they used cannabis to treat their symptoms, it was ranked it as the most effective treatment option out of vitamins, prayer, massage, art therapy, music therapy and relaxation (Finseth, et al., 2015).

In addition, CBD may help with those Parkinson’s’ disease patients experiencing psychosis. Four weeks of CBD caused Parkinson’s disease patients with psychosis to experience a significant decrease in psychotic symptoms as evaluated by the Brief Psychiatric Rating Scale and the Parkinson Psychosis Questionnaire (Zuardi, et al., 2009).

The article above is from (dated 9/9/2016) http://www.medicalmarijuanainc.com/parkinsons-disease-medical-marijuana-research

Twenty one (21) subjects were assigned to three groups of seven subjects each who were treated with placebo, cannabidiol (CBD) 75 mg/day or CBD 300 mg/day. One week before the trial and in the last week of treatment subjects were evaluated with respect to motor and general symptoms score (UPDRS) and well-being and quality of life (PDQ-39).

No statistically significant differences were found in UPDRS scores. Despite the very small sample size, groups treated with placebo and CBD 300 mg/day had significantly different mean total scores in the PDQ-39 (p = 0.05). Significance is very much a factor of sample size, so this result is striking in itself. Findings suggest a possible effect of CBD in improving quality of life measures in PD patients with no psychiatric comorbidities.

Inhaling whole-plant cannabis provides symptomatic relief in patients with Parkinson’s disease (PD), according to a scientific article published in the March/April edition of the journal Clinical Neuropharmacology. Investigators at Tel Aviv University, Department of Neurology evaluated Parkinson’s disease symptoms in 22 patients at baseline and 30-minutes after inhaling cannabis.

Researchers reported that inhaled cannabis was associated with “significant improvement after treatment in tremor, rigidity, and bradykinsea (slowness of movement). There was also significant improvement of sleep and pain scores. No significant adverse effects of the drug were observed.”

The researchers concluded that their study is “the first to report an amelioration of both motor and non–motor symptoms in patients with PD treated with cannabis. The study opens new venues for treatment strategies in PD especially in patients refractory to current medications.”

The administration of cannabidiol (CBD) was found to control sleep disorders in patients who currently experience the symptoms of Parkinson’s disease as reported in the Journal of Clinical Pharmacy and Therapeutics. An international team of researchers from the University of Sao Paulo in Brazil and the University of Minnesota Medical School USA evaluated the ingestion of CBD by four Parkinson’s disease patients with REM sleep behavior disorder (RBD). This condition is characterized by nightmares and active behavior during dreaming.

Cannabidiol treatment reduced symptoms in each of the four subjects. Symptoms returned with the same frequency and intensity following subjects’ discontinuation of the cannabinoid.

Bottom Line

The CBD treatment options seems to be a good one to consider, especially if you are having significant challenges with functioning on a day to day basis. There is research on the use of CBD that address problems related to trauma, anxiety post traumatic stress – all of which lie at the core cause of neurological difficulties.

As with any natural treatment option, be sure to check with your healthcare provider to insure that use of CBD will not interfere with any treatments your doctor has prescribed for you. Do your own research as well. You do not necessarily need medical marijuana and the hassel that comes with it, CBD Hemp oil might be the perfect option for you.

Articles and Studies on Cannabidiol (CBD) and Parkinson’s Disease (PD)

]]>Exploring Effects Of Cannabinoids On Blood Pressurehttp://www.hempoilfacts.com/exploring-effects-of-cannabinoids-on-blood-pressure/
Mon, 08 Aug 2016 17:18:02 +0000http://www.hempoilfacts.com/?p=1346Cannabinoids (including CBD, CBC, THC and many others) have individualistic effects on the human body along with a collective effect (termed the Entourage Effect).

The following graphics show some of the known effects of some of the Cannabinoids:

The following is an abstract from an article from Tulane University:
Hypertension — or high blood pressure — is a long-term, high-risk condition for millions of people worldwide.

At the moment, synthetic beta-blockers are one of the most common drugs prescribed to treat hypertension.

Cannabis “has lots of different chemicals inside. Some of them are painkillers. Some of them, we don’t know what they are doing.”

Andrei Derbenev, associate professor of physiology, School of Medicine

But what if a natural drug, marijuana, which has been known for 5,000 years, could be used in the treatment of high blood pressure?

Andrei Derbenev, associate professor of physiology in the Tulane University School of Medicine, recently received a four-year, $1.5 million research grant from the National Institutes of Health to study how cannabinoids — the compounds of cannabis (another name for marijuana) — affect a brain stem area involved in blood pressure control.

His research may have important clinical applications for the treatment of hypertension.

He is identifying the cells in the sympathetic nervous system linked to the kidneys, a key organ in hypertension. (The sympathetic nervous system is the part of the autonomic nervous system that stimulates the body’s “fight or flight” response. Overactivity of the sympathetic nervous system is a cause of high blood pressure.)

He and his research team are studying the effect of exogenous cannabinoids — from the marijuana plant — and endogenous cannabinoids —those naturally produced within the body.

Cannabis “has lots of different chemicals inside. Some of them are painkillers. Some of them, we don’t know what they are doing.”

People ask Derbenev all the time: Is marijuana good? Is it bad? But the debate, he says, should be, instead, “Which works? Which does not work?”

About a decade ago, Derbenev led a study about the effect of cannabinoids on the parasympathetic nervous system, the part of the autonomic nervous system that stimulates the body to “rest and digest.” In that investigation, his team showed the mechanism by which cannabis can reduce digestive spasms and thus decrease vomiting. It’s a finding of great interest to cancer patients experiencing nausea while undergoing chemotherapy.

Accumulating evidence now also suggests that CBD is beneficial in the cardiovascular system.

CBD has direct actions on isolated arteries, causing both acute and time-dependent vasorelaxation. In vitro incubation with CBD enhances the vasorelaxant responses in animal models of impaired endothelium-dependent vasorelaxation. CBD protects against the vascular damage caused by a high glucose environment, inflammation or the induction of type 2 diabetes in animal models and reduces the vascular hyperpermeability associated with such environments. A common theme throughout these studies is the anti-inflammatory and anti-oxidant effect of CBD.

In the heart, in vivo CBD treatment protects against ischaemia-reperfusion damage and against cardiomyopathy associated with diabetes. Similarly, in a different model of ischaemia-reperfusion, CBD has been shown to reduce infarct size and increase blood flow in animal models of stroke, sensitive to 5HT1A receptor antagonism.

Although acute or chronic CBD treatment seems to have little effect on haemodynamics, CBD reduces the cardiovascular response to models of stress, applied either systemically or intracranially, inhibited by a 5HT1A receptor antagonist.

In blood, CBD influences the survival and death of white blood cells, white blood cell migration and platelet aggregation. Taken together, these preclinical data appear to support a positive role for CBD treatment in the heart, and in peripheral and cerebral vasculature. However, further work is required to strengthen this hypothesis, establish mechanisms of action and whether similar responses to CBD would be observed in humans.

More recently it has been shown that Abn-CBD causes vasorelaxation in the human pulmonary artery through similar mechanisms [29]. Taken together, these findings offer support to the presence of an endothelial bound Gi/o protein coupled receptor that causes vasorelaxation through hyperpolarization that is activated by Abn-CBD.
In human mesenteric arteries, we have very recently shown that CBD causes vasorelaxation of U46619 and endothelin-1 pre-constricted arterial segments (Stanley & O’Sullivan, 2012, under review). In human mesenteric arteries, CBD-induced vasorelaxation has a pEC50 in the mid-micromolar range which is similar to that observed in rat mesenteric arteries. However, CBD-induced vasorelaxation in human arteries has a maximal response of ∼40% reduction of pre-imposed tone. We went on to show that CBD-induced vasorelaxation in human mesenteric arteries is endothelium-dependent, involves CB1 receptor activation and TRPV channel activation, nitric oxide release and potassium hyperpolarization (Figure 1) (Stanley & O’Sullivan, 2012, under review).

CBD is known to be anxiolytic. CBD treatment reduces anxiety related to public speaking or fearful stimuli in humans [10]. A number of studies have now also shown that CBD reduces the cardiovascular response to anxiety or stressful situations. Resstel and colleagues have shown in Wistar rats that a single dose of CBD (10 or 20 mg kg−1 i.p.) reduced the heart rate and blood pressure response to conditioned fear [49] or to acute restraint stress [48]. The inhibitory effect of CBD on the cardiovascular response to stress was shown to be inhibited by WAY100635, a 5HT1A receptor antagonist. This effect appears to be mediated in the brain, as the same effect of CBD on cardiovascular responses could be mimicked when CBD was injected into the bed nucleus of the stria terminalis (a limbic structure) [50]. The potential ability of CBD treatment in humans to reduce the cardiovascular (as well as behavioural) response to stress could have significant effects on the development of atherosclerosis and hypertension, which are known to be accelerated by stress [51, 52].

There is a growing body of evidence that administration of CBD can ameliorate the negative effects of conditions associated with endothelial dysfunction. The high glucose conditions associated with diabetes have been reported as a causal factor in endothelial dysfunction. High glucose promotes inhibition/uncoupling of endothelial nitric oxide, increased superoxide production, increased actions of constrictor prostanoids, decreased actions of vasorelaxant prostanoids and increased reactive oxygen species [59]. Alongside these changes, high glucose is also reported to increase leucocyte adhesion and monocyte endothelial migration [60], which has been reported to be through NFκB activity [61].

Find the full study here http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3579247/

]]>It’s not all about CBD! Find About the Five Amazing Medical Benefits of Cannabichromene (CBC)http://www.hempoilfacts.com/its-not-all-about-cbd-find-about-the-five-amazing-medical-benefits-of-cannabichromene-cbc/
Wed, 03 Aug 2016 03:03:06 +0000http://www.hempoilfacts.com/?p=1338There are over 110 cannabinoids that we currently know about. Each with its own value! While Cannabidiol (CBD) is the most abundant, and most studied cannabinoid, others play a major role on their own. Together, all the cannabinoids work to produce an even stronger benefit, thanks to the Entourage Effect.

The 5 Benefits of Cannabichromene (CBC) are:

CBC encourages brain growth

An Antidepressant

Anti-inflammatory

Pain fighter

Antibacterial and antifungal

A quote from the article:

“Another early study found that CBC had significant antibacterial properties. The cannabinoid put dreaded E. coli and staph colonies in their place. CBC also had “mild to moderate” anti-fungal properties as well.

This information goes hand-in-hand with a more recent study, which found that CBC and other cannabinoids were as effective as Vancomycin against MRSA.

Cannabinoids are fascinating chemicals. Not only do they have powerful medicinal qualities as individual compounds, but they work together synergistically to create more potent effects. Each and every cannabinoid deserves some time in the spotlight.”

]]>Plus CBD vs. Kannaway’s Productshttp://www.hempoilfacts.com/plus-cbd-vs-kannaways-products/
Wed, 15 Jun 2016 01:34:52 +0000http://www.hempoilfacts.com/?p=1214A friend of mine thought he found a better deal when he found a popular brand of CBD called +CBD on a very popular website. However, upon closer examination, I showed him the facts about that product, and that he would actually pay more, for an inferior product!

Here are some of the details for those who are detail oriented:

With this spray, you get 80 servings (1.25 mg each) of premium-quality, all-natural, and extra-strong CBD oil. Simply spray twice on your tongue and get an instant taste of CBD goodness with no hassle and a tasty kick.

Let’s Examine This Product:

The CBD:

I do not know where the +CBD CBD oil comes from. I however know that Kannaway’s CBD oil comes from family farms in Austria, from a special high CBD cultivar, grown sustainably, without any chemicals (pesticide-free, herbicide-free, fertilizer-free), non-GMO, and undergoes a 3rd party testing process. It is then manufactured in California.

This +CBD bottle contains 100mg of CBD only, and the sale price is $47. This comes to $0.47 per mg of CBD. Now consider the Kannaway Revive Pro bottle, boasting a massive 2,046 mg of potent CBD fpr $225 (for loyal customers), this comes to be $0.11 per mg of CBD. Even if you purchase it at retail (no loyal customer pricing) it comes to $0.145 per mg of CBD. A huge difference! If you wanted a smaller bottle, you can take a look at the Revive AM bottle with 300mg of CBD for $82, this comes to $0.273 per mg of CBD.

I found this label for the same 100mg per bottle product, the ingredients don’t match exactly however, Sorbates remain an issue. It seems the flavor here is from peppermint oil which is good.

You do “not” want the Sorbates in your supplement. You also should find out where their ‘natural flavor’ comes from. Kannaway’s ingredients contain “no” preservatives, no sorbates for sure, and their flavors come from actual fruit extracts. Kannaway also has the Bibong formula which is a huge added value and enhances the effects of the CBD massively.

You do not want synthetic chemicals such as sorbates or flavors. Studies have shown Sorbates to be a harmful DNA toxin. Contact me for more details.

The choice is clear. Better quality, better reputation, better ingredients, better pricing. This is why I buy Kannaway! This is why I affiliate myself with Kannaway and not only enjoy the products but also make a residual income consuming and sharing what I believe in.

In the past decade, the endocannabinoid system has been implicated in a growing number of physiological functions, both in the central and peripheral nervous systems and in peripheral organs… modulating the activity of the endocannabinoid system turned out to hold therapeutic promise in a wide range of disparate diseases and pathological conditions, ranging from mood and anxiety disorders, movement disorders such as Parkinson’s and Huntington’s disease, neuropathic pain, multiple sclerosis and spinal cord injury, to cancer, atherosclerosis, myocardial infarction, stroke, hypertension, glaucoma, obesity/metabolic syndrome, and osteoporosis, to name just a few…

A primary example of the endocannabinoid system’s role in homeostasis comes from research that has identified an overexpression of cannabinoid receptors in the tumor cells of various cancer diseases, including lung cancer, liver cancer, breast cancer and prostate cancer. Research has also shown that tumor growth can be inhibited and even reversed when cannabinoids such as THC are administered.

Interestingly, research suggests that this defence system is not only useful in treating cancer, but may also be beneficial in the treatment of a wide variety of conditions. Current evidence points to the endocannabinoid system as being a potential therapeutic target for the following list of disorders:

]]>Article: The Truth About the US Government’s CBD Patenthttp://www.hempoilfacts.com/article-the-truth-about-the-us-governments-cbd-patent/
Tue, 07 Jun 2016 21:04:43 +0000http://www.hempoilfacts.com/?p=1181The text below is quoted from an article for archival and educational purposes:

The American government owns a CBD patent even though the plant that it comes from isn’t exactly legal on a federal level.

“The NIH may have gotten the patent to control the use of CBDs and prevent them from being added to the list of controlled substances,” said Bob Hoban, a cannabis and CBD attorney in Denver. “If the government controls the patent for CBDs, they can stop scientists and manufacturers from researching and creating synthetic CBD products.”

CBD refers to cannabinoids, which are compounds in the marijuana plant that have medical benefits without psychoactive impact.

“They have licensed this patent to companies that are creating and investigating cannabinoid compounds for the treatment of disease,” said Douglas Sorocco, a biochemist and intellectual property lawyer in Oklahoma.

KannaLife Science is one company that has obtained a license to that patent. “We have right of first refusal for non pharmaceutical products created by KannaLife Sciences,” said Edgar Montero, vice president of international expansion with Kannaway, an Amway-like CBD and hemp network marketing company.

According to Hoban, “You can’t sell CBD pharmaceuticals in the U.S. without going through the government to get permission.” Obtained in October 2003, US Patent 6630507, titled cannabinoids as antioxidants and neuroprotectants, is owned by the National Institutes of Health.

“This patent indicates that the NIH is doing one of its jobs, which is researching the effectiveness of certain compounds for the treatment of highly debilitating diseases and costly medical conditions,” Sorocco said.

Marijuana strains however will not be patented until the plant is legalized on a federal level or taken off the list of Schedule I drugs. “Lots of marijuana entrepreneurs have tried to patent their strain of marijuana but it’s illegal,” Hoban said. “CBDs are not illegal.”
Source: http://mjinews.com/truth-us-governments-cbd-patent/

]]>The US Government Acknowledges the Healing Power of CBD – They Even Have a Patent on CBDhttp://www.hempoilfacts.com/the-us-government-acknowledges-the-healing-power-of-cbd-they-even-have-a-patent-on-cbd/
Tue, 07 Jun 2016 20:49:52 +0000http://www.hempoilfacts.com/?p=1180Cannabidiol (CBD) is a natural constituent of the Industrial Hemp Plant that promotes and supports the nutritional health of the human body and nourishes and supports the Endocannabinnoid system.

]]>Sanjay Gupta’s CNN Special on Cannabishttp://www.hempoilfacts.com/sanjay-guptas-cnn-special-on-cannabis/
Mon, 30 May 2016 06:49:01 +0000http://www.hempoilfacts.com/?p=1136Below watch 3 videos, from a CNN special, by Dr Sanjay Gupta. It shows how Cannabis (and CBD, Hemp) is used to help many, MS, pain, seizures, and PTSD are some of the conditions cannabis helps with. You must note that Hemp is cannabis, and Hemp offers us very low THC and high CBD.. CBD is safer, with no side effects (no high). Hemp is a great medicine! Hemp and Marijuana are Cannabis.. The benefit of Hemp is that it is very low in THC and higher in CBD than Marijuana. You can get Hemp oil today legally anywhere in the US. See our recommendation here, in the menu above.

Video 1

Video 2

Video 3 – How Vaping can help veterans with PTSD!

]]>What is Hemp? Vimeo videohttp://www.hempoilfacts.com/what-is-hemp-vimeo-video/
Mon, 30 May 2016 05:47:48 +0000http://www.hempoilfacts.com/?p=1124This video was posted on Vimeo on January 2016

Hemp Oil is high in CBD and very low <0.3% in THC, delivers the health benefits without the high

A study by the International Association of Plant Taxonomy explained that marijuana and hemp are both of the same genus (cannabis) and species (sativa), but hemp by definition has only trace amounts of tetrahydrocannabinol (THC). For this reason, smoking hemp will not produce a psychoactive high. Despite this fact, the Marihuana Tax Act of 1937 still outlawed the cultivation of hemp in the United States. For this reason, conspiracists often argue that William Randolph Hearst, the Du Pont family, Andrew Mellon and other tycoons pushed for hemp prohibition as a way to protect their business interests, including paper and nylon production. The conspiracy theories may or may not be true, but the cotton industry has enough clout to extract about $600 million in federal subsidies each year, which often go to absentee millionaire farmers. What is more certain is that hemp is on the verge of a comeback.
With the Canadian hemp market raking in about $1 billion a year, the U.S. finally loosened its prohibition on hemp. A provision in the 2014 farm bill removed research-related hemp from the federal Controlled Substances Act (CSA), which had classified it as fully illegal Schedule I substance. The move was not a full repeal of the prohibition, and challenges still exist since it can be difficult to tell the difference between hemp and psychoactive cannabis. However, the hemp comeback has turned the corner, and a deeper cotton vs. hemp debate is heating up.
Music: “J I 1” – Copyright & License provided by Format Entertainment formatent.com/