DeWine said Issue 3 doesn't regulate what kind of food items could be made in the Buckeye State or how they're packaged.

"I think there absolutely should be very clear labeling of how much one should take and the packages should be in one dose quantities if possible. Now, the fact that the law doesn't specify that right away, I don't think is a reason to oppose the law, but certainly it's something that should be looked at as an alteration to the issue if it were to pass," UC's history department associate professor Isaac Campos said.

One financial backer of Issue 3 said Ohio's marijuana control commission, which would be created by the passage of the constitutional amendment, would determine what kinds of edibles would be appropriate to sell in Ohio.