US President Barack Obama has called for stronger gun control laws, saying the frequency of mass shootings in the US is unparalleled by any other country in the world.

Mr Obama listed stricter gun laws and stronger back ground checks as changes which need to be made.

“We have a pattern now of mass shootings in this country which has no parallel anywhere else in the world,” Mr Obama said in an interview with CBS News after being informed about the shootings.

“There are steps we can take to make America safer,” he said.

“We should come together in a bipartisan basis at every level of government to make these rare as opposed to normal.

“We have a no-fly list where people can’t get on planes, but those same people who we don’t allow to fly could go into a store right now in the United States and buy a firearm and there’s nothing we could do to stop them, that’s a law that needs to be changed,” he said.

Local authorities believe up to three suspects are on the run. (AAP)

The 2016 US Presidential candidates have also responded to the mass shooting, some sending their prayers to victims and others also calling for active changes to gun laws.

Hillary Clinton responded to the news on Twitter immediately, condemning the frequency at which mass shootings are taking place in the US, saying she refuses “to accept this as normal”.

Clinton is strongly in favour of gun control and her 2016 presidential campaign has called for a “national movement” to “stand up to the NRA”, TIME reports.

“What is wrong with us, that we cannot stand up to the NRA and the gun lobby, and the gun manufacturers they represent?” she asked after the Oregon shooting last month which left 10 people dead.

“We need to act and we need to build a movement. It’s infuriating.”

GOP Candidate Donald Trump also tweeted about the shootings, thanking police for their efforts at the shooting and sending them his blessing.

Trump has a strong stance against gun control and publicly blamed tough gun control laws for the terrorist attacks which took place in Paris last month.

"You can say what you want, but if they had guns -- if our people had guns, if they were allowed to carry -- it would have been a much, much different situation," Trump said at a political rally in Texas on November 14.