Found (909) clinical trials

The purpose of this study is to evaluate the potential effects of an intravenous (IV) induction and subcutaneous (SC) maintenance administration of ustekinumab on the pharmacokinetic (PK) of a cocktail of representative probe substrates of cytochrome P450 (CYP) enzymes (CYP3A4, CYP2C9, CYP2C19, CYP2D6, and CYP1A2) in participants with moderate to ...

The purpose of this study is to assess the pharmacokinetics of single-dose evening administration of JNJ-42847922 in elderly non-Asian adults compared with weight- and gender-matched young healthy non-Asian adults and to assess the pharmacokinetics of single-dose evening administration of JNJ-42847922 in healthy Japanese adults.

"This is a single-center, randomized, double-blind, and placebo-controlled trial designed to: demonstrate the degree to which administered andexanet doses can reverse Factor Ten A (FXa)-inhibitor induced anticoagulation; and 2) evaluate the safety and PK/PD of andexanet in healthy Japanese subjects taking direct FXa inhibitors at therapeutic doses."

WCCT Global is seeking males and females ages 20 to 75 years old that are diagnosed with Osteopenia and currently on Glucocorticoids to participate in a clinical research study of an investigational drug. Your participation is necessary for new and innovative treatments for Osteopenia.

Do you have Rheumatoid Arthritis? WCCT Global is seeking volunteers who have been diagnosed with Rheumatoid Arthritis for at least 6 months to participate in a medical research study with an investigational medication. Participants may receive: Up to $2,350 for time and travel Study related care at no cost Investigational ...

Are You Healthy? WCCT Global is looking for healthy males and females ages 18 to 49 to participate in a clinical research study with an investigational medication. Qualified participants may receive: Up to $1,200 for time and travel Study related care at no cost An investigational medication To see if ...

This is a randomized, double-blind, single center study in healthy volunteers dosed to steady state with betrixaban, designed to (1) Determine an andexanet dosing regimen required to reverse anticoagulant activity of betrixaban in healthy subjectss, (2) Assess the safety and tolerability of andexanet vs. placebo (3) Determine the PK properties ...