Okay, that was HARD! I have about 50 couples I absolutely adore! Making me pick just a half of them is cruel ;P

Honorable mentions: House and Cuddy, Sylar and Elle, Nate and Serena, Mark and Lexie, Owen and Cristina, Marshall and Lily, Pete and Addison, Cooper and Charlotte, Michael and Maria, Phoebe and Mike, Doyle and Cordelia, Oliver and Lois, Eric and Donna, Seth and Summer, Castle and Beckett ;)