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I came down with a sinus infection 6 days after my last polotherapy treatment and am now on a ten day course of antibiotics to get rid of it. Will the infection have any deleterious effects on ongoing proliferation from previous treatments or has the immune system response to initiate that cascade already taken place? I skipped this week's treatment and will wait until next week to continue. I assume that being on the antibiotic itself will not decrease the efficacy of treatment so long as the active infection is gone.

Is it possible for the connective tissue to hypertrophy too much; i.e. can the supraspinatus tendon become large enough from prolotherapy that is will no longer move freely within the subacromial space? If that is a possibility, how will I know when to discontinue treatments on that region before it happens?

It is my opinion that a minor infection at another location in the body would have little effect on the results of prolotherapy. The immune system has the ability to multi-task to a high degree. Personally, I would not worry about it.

As to hypertrophy, theoretically it could be a problem, however I have never heard of it. In dealing with a tendon, the objective is to persuade all the individual fibers to regain their original lengths, connections, and strengths. As far as I know, prolotherapy does not have the ability to stimulate the creation of new fibers within a tendon. In general, prolotherapy should be stopped at the time symptoms have disappeared.