Knowledge Center

Patent / 2002

Crystallization process for the preparation of crystalline and solvent-free iohexol

Hovione Inter Ltd.

Authors:

Guy Villax

Carlos Alvarez

Source:

US 6469208

Industrial process for the purifn. and removal of residual solvents from iohexol, is presented which is based on the suspension of cryst. iohexol, eventually contg. residual solvents above 100 ppm, a fluid whereit has a low soly., followed by heating, filtration, and drying. This process enables the formation of cryst. iohexol with no residual org. residual solvent above 100 ppm and with increased purity level.