General Info

Alternative names

dCK

DCK protein

DCK_HUMAN

Deoxycytidine kinase

Deoxynucleoside kinase

EC 2.7.1

EC 2.7.1.74

MGC117410

MGC138632

OTTHUMP00000219118

OTTHUMP00000219119

see all

FunctionRequired for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents.

Sequence similaritiesBelongs to the DCK/DGK family.

Post-translationalmodificationsPhosphorylated upon DNA damage, probably by ATM or ATR.