Former pitcher Dipoto was hired as the Arizona Diamondbacks Director of Player Personnel and Director of Professional Scouting on November 1, 2005. He later was promoted to Vice-President. On July 1, 2010, he was named interim General Manager, replacing Josh Byrnes. He was named GM of the Angels in October of 2011, replacing Tony Reagins. He did not wait long to make a splash: on December 8th, he announced two huge free agent signings, 1B Albert Pujols for 10 years and $254 million, and P C.J. Wilson for 5 years and $77.5 million. Another big signing, that of OF Josh Hamilton the following year, did not turn out so well as Hamilton was injured, saw his production decline, and then suffered a relapse of substance abuse problems. In the the end, the Angels had to swallow a large percentage of his contract to send him back to the Texas Rangers in early 2015. On July 1st that year, Dipoto resigned abruptly over rumored differences with manager Mike Scioscia; it was stated that Dipoto wanted the organization to turn more towards statistical analysis, while Scioscia had a more old school approach. The long-time manager won out, and Dipoto was replaced on an interim basis by former GM Bill Stoneman.