Affiliations
Department of Neurological Surgery, University of California Irvine, Irvine, California, United States of America,
State Key Laboratory of Oncology in South China and Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China

Affiliations
Guizhou Provincial Key Laboratory of Computational Nano-Material Science, Guizhou Normal College, Guiyang, China,
Department of Statistics, University of Akron, Akron, Ohio, United States of America,
Department of Family and Community Medicine, Northeast Ohio Medical University, Rootstown, Ohio, United States of America,
Department of Pathology & Laboratory Medicine, University of California Irvine, Irvine, California, United States of America

Affiliations
Department of Biological Chemistry, University of California Irvine, Irvine, California, United States of America,
Department of Neurological Surgery, University of California Irvine, Irvine, California, United States of America

Affiliation
Department of Biological Sciences, Virginia Polytechnic Institute and State University, Blacksburg, California, United States of America

Hang Zhang

Affiliation
Department of Biological Sciences, Virginia Polytechnic Institute and State University, Blacksburg, California, United States of America

Chao Ke

Affiliations
Department of Neurological Surgery, University of California Irvine, Irvine, California, United States of America,
State Key Laboratory of Oncology in South China and Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China

Fengrong Yan

Affiliation
Department of Neurological Surgery, University of California Irvine, Irvine, California, United States of America

Jodi Nelson

Affiliation
Department of Neurological Surgery, University of California Irvine, Irvine, California, United States of America

Zhenzhi Li

Affiliation
Department of Neurological Surgery, University of California Irvine, Irvine, California, United States of America

Robert Gramer

Affiliation
Department of Neurological Surgery, University of California Irvine, Irvine, California, United States of America

Liping Yu

Affiliation
Ziren Research LLC, Irvine, California, United States of America

Eric Siegel

Affiliation
Department of Biostatistics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America

Xiaona Zhang

Affiliation
National Engineering Center for Biochip at Shanghai, Shanghai, China

Zhenyu Jia

Affiliations
Guizhou Provincial Key Laboratory of Computational Nano-Material Science, Guizhou Normal College, Guiyang, China,
Department of Statistics, University of Akron, Akron, Ohio, United States of America,
Department of Family and Community Medicine, Northeast Ohio Medical University, Rootstown, Ohio, United States of America,
Department of Pathology & Laboratory Medicine, University of California Irvine, Irvine, California, United States of America

Affiliations
Department of Biological Chemistry, University of California Irvine, Irvine, California, United States of America,
Department of Neurological Surgery, University of California Irvine, Irvine, California, United States of America

Competing Interests

Liping Yu is an employee of Ziren Research LLC, Irvine, CA, USA. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.