STRING allows inspection of the interaction evidence for any given network. Choose any of the viewers above (disabled if not applicable in your network).

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:query proteins and first shell of interactors

white nodes:second shell of interactors

Node Content

empty nodes:proteins of unknown 3D structure

filled nodes:some 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

slr0864

ABC transporter (574 aa)

Predicted Functional Partners:

rpl1

50S ribosomal protein L1; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (238 aa)

0.872

rpl5

50S ribosomal protein L5; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs (180 aa)

a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1

node2

node1 accession

node2 accession

node1 annotation

node2 annotation

score

rpl1

rpl5

SYNGTS_0844

SYNGTS_0763

50S ribosomal protein L1; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release

50S ribosomal protein L5; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs

0.999

rpl1

rpmG

SYNGTS_0844

SYNGTS_2546

50S ribosomal protein L1; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release

50S ribosomal protein L33

0.985

rpl1

slr0864

SYNGTS_0844

SYNGTS_1234

50S ribosomal protein L1; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release

ABC transporter

0.872

rpl5

rpl1

SYNGTS_0763

SYNGTS_0844

50S ribosomal protein L5; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs

50S ribosomal protein L1; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release

0.999

rpl5

rpmG

SYNGTS_0763

SYNGTS_2546

50S ribosomal protein L5; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs

50S ribosomal protein L33

0.959

rpl5

slr0864

SYNGTS_0763

SYNGTS_1234

50S ribosomal protein L5; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs

ABC transporter

0.871

rpmG

rpl1

SYNGTS_2546

SYNGTS_0844

50S ribosomal protein L33

50S ribosomal protein L1; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release

0.985

rpmG

rpl5

SYNGTS_2546

SYNGTS_0763

50S ribosomal protein L33

50S ribosomal protein L5; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs

0.959

rpmG

slr0864

SYNGTS_2546

SYNGTS_1234

50S ribosomal protein L33

ABC transporter

0.841

rpmG

slr1037

SYNGTS_2546

SYNGTS_0601

50S ribosomal protein L33

CheY subfamily protein Rre10

0.694

sll0163

sll0167

SYNGTS_2101

SYNGTS_2099

Beta transducin-like protein

Hypothetical protein

0.974

sll0163

sll1672

SYNGTS_2101

SYNGTS_0230

Beta transducin-like protein

Hybrid sensory kinase Hik12

0.850

sll0163

sll1673

SYNGTS_2101

SYNGTS_0229

Beta transducin-like protein

Regulatory component of sensory transduction system Rre2

0.828

sll0163

slr0864

SYNGTS_2101

SYNGTS_1234

Beta transducin-like protein

ABC transporter

0.843

sll0163

slr1037

SYNGTS_2101

SYNGTS_0601

Beta transducin-like protein

CheY subfamily protein Rre10

0.821

sll0163

slr1259

SYNGTS_2101

SYNGTS_1277

Beta transducin-like protein

Hypothetical protein

0.826

sll0163

slr1261

SYNGTS_2101

SYNGTS_1279

Beta transducin-like protein

Hypothetical protein

0.848

sll0167

sll0163

SYNGTS_2099

SYNGTS_2101

Hypothetical protein

Beta transducin-like protein

0.974

sll0167

sll1672

SYNGTS_2099

SYNGTS_0230

Hypothetical protein

Hybrid sensory kinase Hik12

0.845

sll0167

sll1673

SYNGTS_2099

SYNGTS_0229

Hypothetical protein

Regulatory component of sensory transduction system Rre2

0.845

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Network Stats

Network Stats analysis is still ongoing, please wait ...

Functional enrichments in your networkNote: some enrichments may be expected here (why?)

Enrichment analysis is still ongoing, please wait ...

Statistical background

For the above enrichment analysis, the following statistical background is assumed: