In the elderly population, proneurotensin independently predicts development of cardiovascular diseases in both genders, whereas it only predicts diabetes in women.

Neurotensin plasma values differentiate healthy people from patients suffering from colonic pathologies such as adenomatous polyps and adenocarcinoma.

NTS may be an important stimulus to promote hepatocellular carcinoma invasion and metastasis both in vitro and in vivo.

Higher concentrations of proneurotensin are associated with a greater risk of incident cardiovascular events in the community. This association did not vary according to sex, baseline low-density lipoprotein, or sortilin receptor 1 genotype.

sortilin is a PIP3 binding protein with binding likely to occur at the C-terminal neurotensin binding site, and is a competitor of neurotensin

children with untreated coeliac disease have elevated peripheral pro-NT levels compared with disease controls. Pro-NT levels also seem to reflect more severe forms of active coeliac disease, indicating a potential role of NT in small intestinal inflammation.

findings directly link NT with increased fat absorption and obesity and suggest that NT may provide a prognostic marker of future obesity and a potential target for prevention and treatment

Although no measures for pain threshold, thermal instability or gastric motility were performed in our study participants, higher plasma NT levels were found in PWS children

Neurotensin and its receptor NTSR1 causes EGFR, HER2 and HER3 over-expression and their autocrine/paracrine activation in lung adenocarcinomas, confirming responsiveness to erlotinib.

indicate that neurotensin is a direct target of the Wnt/beta-catenin pathway and may be a mediator for neuroendocrine tumor cell growth

The antimicrobial peptide neurotensin has activity against invasive microbes.

Results show that both the neurotensin (NT) and the neurotensin 1 receptor hNTS1(321-344)fragment present a 3D structure in complex.

NT production by keratinocytes may exert a paracrine effect on other skin cells, namely fibroblasts, macrophages, and dendritic cells for correct wound healing.

These findings provide new insights into the potential therapeutic role of NT in chronic wounds, such as in DFU, characterized by a deficit in the migratory properties of cells and a chronic proinflammatory status.

Cow (Bovine) Neurotensin (NTS) interaction partners

The pigmented cells of the ocular ciliary epithelium release neurotensin (NT) in response to inducing agents, whereas the nonpigmented cells exhibit a significantly reduced NT secretion in response to inducers, leading to accumulation of the peptide.

Mouse (Murine) Neurotensin (NTS) interaction partners

Study reveals multiple populations of neurotensin neurons that provide direct afferents to the ventral tegmental area and which may regulate specific aspects of motivated behavior.

The weight loss behaviors are mediated by distinct signaling pathways: Nts action via NtsR1 is essential for the anorectic effect of the lateral hypothalamic Nts circuit, but not for regulation of locomotor or drinking behavior.

Nts-leptin receptor neurons are important neuronal hubs within the lateral hypothalamic area for hormone-mediated control of ingestive and locomotor behaviors.

findings directly link NT with increased fat absorption and obesity and suggest that NT may provide a prognostic marker of future obesity and a potential target for prevention and treatment

although neurotensin neurons in the anteroventral periventricular nucleus are targets for regulation by E(2), neurotensin does not appear to play a direct role in generating the GnRH/LH surge in the mouse

neurotensin has a role in chronic mitogen-activated protein kinase activation and cancer progression

Data show that although brain neuromedin N mRNA distribution largely overlaps in mice and rats, species differences exist in specific brain areas, and the distribution in mice resembles that of primates more than that of rats.

NT and NTR1 are part of network activated after mucosal injuries, and NT stimulates epithelial restitution, at least in part, through a COX-2 dependent pathway.

Neurotensin may have a direct role in the neuroendocrine control of feeding and energy homeostasis.

co-localization of peptides and enzyme in GHRH-eGFP neurons displays a sexual dimorphism at 3-month of age for NT, and at 8-month for tyrosine hydroxylase, while the total number of GHRH-eGFP neurons does not exhibit gender difference at either age.

[(99m)Tc]Demotensin 6 shows a favourable preclinical profile and further testing in patients is warranted to monitor its eventual applicability as a radiotracer in the diagnostic imaging of NTS1-R-positive tumours.

These results clearly indicate for the first time that NT is able to protect endocrine beta cells from external cytotoxic agents, a role well correlated with its release in the circulation after a meal.

Pig (Porcine) Neurotensin (NTS) interaction partners

Human, pig, and frog NT and [Gln(4)]NT and [D-Tyr(11)]NT adsorbed to the silver surface via the tyrosine ring, the oxygen atom of the deprotonated phenol group of Tyr(11), and the -CH(2)- unit(s), most probably of Tyr(11), Arg(9), and/or Leu(13).

Neurotensin (NTS) Antigen Profile

Antigen Summary

This gene encodes a common precursor for two peptides, neuromedin N and neurotensin. Neurotensin is a secreted tridecapeptide, which is widely distributed throughout the central nervous system, and may function as a neurotransmitter or a neuromodulator. It may be involved in dopamine-associated pathophysiological events, in the maintenance of gut structure and function, and in the regulation of fat metabolism. Tissue-specific processing may lead to the formation in some tissues of larger forms of neuromedin N and neurotensin. The large forms may represent more stable peptides that are also biologically active.