Listed below are peer-reviewed publications that highlight the technology and applications of
multiplexed proteomics. Several of the publications below were
contributed by the founders of IQ Proteomics

As a driver for many biological processes, phosphorylation remains an area of intense research interest. Advances in
multiplexed quantitation utilizing isobaric tags (e.g., TMT and
iTRAQ) have the potential...

Multiplexed quantitation via isobaric chemical tags (e.g., TMT and iTRAQ) has the potential to
revolutionize quantitative proteomics. However, until recently the utility of these tags was
questionable due to reporter ion ratio distortion resulting from fragmentation of
co-isolated interfering species. These interfering signals...

Targeted mass spectrometry assays for protein quantitation monitor peptide surrogates, which are easily multiplexed to target many peptides in a single assay.
However, these assays have generally not taken advantage of sample multiplexing, which allows up to ten analyses to occur in parallel.
We present a two-dimensional multiplexing workflow...

The development of effective pharmacological inhibitors of multidomain scaffold proteins,
notably transcription factors, is a particularly challenging problem. In part, this is because
many small-molecule antagonists disrupt the activity of only one domain in the target protein.
We devised a chemical strategy that promotes ligand-dependent target protein degradation...

Brown and beige adipose tissues can dissipate chemical energy as heat through thermogenic
respiration, which requires uncoupling protein 1 (UCP1). Thermogenesis from these adipocytes can
combat obesity and diabetes, encouraging investigation of factors that control UCP1-dependent
respiration in vivo. Here we show that acutely activated thermogenesis in brown adipose...

Targeted protein quantification using liquid chromatography–tandem mass spectrometry with stable isotope-labeled standards is recognized as the
gold standard of practice for protein quantification. Such assays, however, can only cover a limited number of proteins...