Syndrome of Inappropriate Antidiuretic Hormone Secretion

Syndrome of inappropriate antidiuretic hormone secretion (SIADH) is a rare condition that occurs when your child’s body produces too much antidiuretic hormone (ADH). ADH helps regulate the amount of water in the body. In SIADH, the body retains too much water, which leads to low sodium levels in the blood.

Causes

SIADH may be caused by:

Injury to the head or brain that affects the thalamus (which helps regulate hormones)

Damage to the hypothalamus or pituitary gland during surgery

Meningitis or encephalitis (types of inflammation affecting the brain)

Brain tumor

Low thyroid or parathyroid hormones

Lung disease

Guillain-Barré syndrome

HIV

Certain medicines

Hereditary causes

Psychosis

Symptoms of SIADH

The symptoms of SIADH may be different for each child. Your child may experience:

Headache

Nausea or vomiting

Cramps or tremors

Irritability or depression

Anger or confusion

Memory problems

Seizures

Hallucinations

Coma

Diagnosis and Treatment at UVA

At UVA, your child’s doctor may perform or recommend:

Blood test

Urine test

Measurement of sodium level

Measurement of potassium level

Children with SIADH may need to limit the amount of fluid they drink. Treatment may also include: