* A pyrimidine-rich associated polypeptide complex is best known as a "protein".

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* A e.coli K12 derived auxotrophic restriction enzyme system may be the key <font color=red>red</font> <font color=purple>heering</font> in understanding protein over-expression factors in the transcription of mRNA.

* What is primary difference between a putative and non-putative gene?

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* Erbb Signaling Pathway: http://www.genome.jp/dbget-bin/www_bget?pathway:map04012 Look for "CAMK" on this map and which conclusions may you draw from its interactions (Cross-talking) with erbb2? Is erbb2 a promoter or a repressor of Calcium-dependent adhesion (and why)?

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* On Hill coefficient (Kd) measurement and analysis:

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** In short, the Hill coefficient is a statistical tool (function) to measure <font color=purple>binding (adhesion)</font> variance when information about a system is poor.

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** <i>As pointed out by Cornish-Bowden and Koshland (1975), the ‘logit’ plot in pharmacology is a plot identical to the Hill plot, and formally equivalent to Nernst's plot of redox electrochemistry (Reed & Berkson 1929, their example 5; Malmstrom 1974). The logit plot is also equivalent to the gating transitions of voltage dependent ion channels (Yifrach 2004). See Section 10.3.9 for more on the relationship between the Nernst and the Hill equations.</i> http://journals.sfu.ca/coactionbks/index.php/Bindslev/article/viewArticle/14/75

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=== Case study: Focus on Hemagglutinin binding factors ===

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* Review this Free PMC [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2025700/ here]. Can you identify the factors which makes the HA protein clump or can you postulate the role and significance of Ca2+ signaling pathway in the viral coating of the H. influenza virus ? Recall that the [http://www.uniprot.org/uniprot/Q9WFX3 Hemagglutinin protein] is solely required for the H. influenza virus to attach into its host and begin an unwary invasion on the immune system.

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* Note 1 (HA cleaving factors): "The extent of infection into host organism is determined by HA. Influenza viruses bud from the apical surface of polarized epithelial cells (e.g. bronchial epithelial cells) into lumen of lungs and are therefore usually pneumotropic. The reason is that HA <font color="purple">is cleaved by tryptase clara which is restricted to lungs. However, HAs of H5 and H7 pantropic avian viruses subtypes can be cleaved by furin and subtilisin-type enzymes, allowing the virus to grow in other organs than lungs."</font> [[http://www.uniprot.org/uniprot/Q9WFX3 1]]

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** Based on this comment above, can you postulate how unwary HA infections may silently avoid immune-specific detection by the host ??

* Moreover assuming the psychochemical media require a ultra-sound frequency (ie: 2.450 GHz) to INDUCE mRNA-activated polypeptide alkane isomerisation of the PTBP1 genes, how mentally retarded do you estimate a human-made decision must be (IQ) to allow and implement the forced installation of such biological assault devices without the consent and informed judgement into the homes and residences of civilians ? -[[User:Etienne_Robillard|ER]]

** '''Important Note: Back in World-war 2, Ziklon-b pellets (Auschwitz) were found to dispense the deadly compound to the prisoneers from the <font color=red>outside</font> of the concentration camps'''. In 2013, however, the dispensed "biopellets" may recombine easily using a electrochemical media ("the pellet dispenser"), hence the forced installation of RF devices (smart meter) into the homes of civilian populations is probably part of the governement modus operandi to enforce biological warfare on civilian populations with X-linked (pyrimidine-rich) N-methyl neuropeptides! -[[User:Etienne_Robillard|ER]]

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** Review this paper [http://aizenmanlab.neurobio.pitt.edu/aizenman_position_files/pdf/ardenkcn.pdf here] about the DNA methylation of neuropeptides with cyanide affects the NMDA receptor. [yet more NMDAR stuff]

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* Review role of [http://web.campbell.edu/faculty/nemecz/323_lect/cofactors/pyridoxal_1.html PLP] (pyridoxal-5-phosphate) in the intermediate synthesis of [[User:Etienne_Robillard/Notebook/Schiff_base|Schiff bases]] (pKa='''11''').

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** Notice the presence of ketimine in the reaction and the '''-rC=N''' alpha-hydrogen bond. [http://www.chem.ucalgary.ca/courses/350/Carey5th/Ch21/ch21-2.html Review acidity of alpha-Hydrogens bonds here]

Abstract

An essay on the role of the Integrin beta-3 protein (ITGB3) in Ca2+-dependent orthogonal riboswitches.

Introduction

In the study of calcium-mediated (Ca2+) neuronal receptors (NMDA and GABA mostly), the relevance of Ca2+-dependent ligands (ie: calmodulin)
may hold important factors in the morphogenesis of psychological brain disorders and the pathogenesis of the Alzheimer disease,
a important phenotype in the understanding of GPCR-mediated brain mutations. Hence a proper understanding of the polypyrimidine tract binding protein-1 (PTBP1) dependent signaling pathway may reveal new insights in the functions and features of the integrin beta-3 protein as a cell-adhesive (and voltage-gated!) neural substrate for long-term axon and neuronal growth. [1]

Notes

A integrin beta3 mutant polypeptide lacking the PTBP1 gene ?

A pyrimidine-rich associated polypeptide complex is best known as a "protein".

A e.coli K12 derived auxotrophic restriction enzyme system may be the key redheering in understanding protein over-expression factors in the transcription of mRNA.

In short, the Hill coefficient is a statistical tool (function) to measure binding (adhesion) variance when information about a system is poor.

As pointed out by Cornish-Bowden and Koshland (1975), the ‘logit’ plot in pharmacology is a plot identical to the Hill plot, and formally equivalent to Nernst's plot of redox electrochemistry (Reed & Berkson 1929, their example 5; Malmstrom 1974). The logit plot is also equivalent to the gating transitions of voltage dependent ion channels (Yifrach 2004). See Section 10.3.9 for more on the relationship between the Nernst and the Hill equations.http://journals.sfu.ca/coactionbks/index.php/Bindslev/article/viewArticle/14/75

Case study: Focus on Hemagglutinin binding factors

Review this Free PMC here. Can you identify the factors which makes the HA protein clump or can you postulate the role and significance of Ca2+ signaling pathway in the viral coating of the H. influenza virus ? Recall that the Hemagglutinin protein is solely required for the H. influenza virus to attach into its host and begin an unwary invasion on the immune system.

Note 1 (HA cleaving factors): "The extent of infection into host organism is determined by HA. Influenza viruses bud from the apical surface of polarized epithelial cells (e.g. bronchial epithelial cells) into lumen of lungs and are therefore usually pneumotropic. The reason is that HA is cleaved by tryptase clara which is restricted to lungs. However, HAs of H5 and H7 pantropic avian viruses subtypes can be cleaved by furin and subtilisin-type enzymes, allowing the virus to grow in other organs than lungs." [1]

Based on this comment above, can you postulate how unwary HA infections may silently avoid immune-specific detection by the host ??