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Multiple system atrophy (MSA)

Formerly called Shy-Drager syndrome, the condition shares many Parkinson's disease-like symptoms, such as slowness of movement, muscle rigidity and poor balance.

Multiple system atrophy is a degenerative disease that develops in adulthood, usually in the 50s or 60s.

Treatment for MSA includes medications and lifestyle changes to help manage symptoms. The condition progresses gradually and eventually leads to death.

Symptoms
Causes
Complications

Multiple system atrophy (MSA) is so named because its signs and symptoms affect multiple parts of your body. Previously called Shy-Drager syndrome, MSA is classified by two types: parkinsonian and cerebellar, depending on which types of symptoms predominate at the time of evaluation.

Parkinsonian type

Predominant signs and symptoms are those of Parkinson's disease, such as:

Rigid muscles and difficulty bending your arms and legs

Slow movement (bradykinesia)

Tremors (rare in MSA compared with classic Parkinson's disease)

Impaired posture and balance

Cerebellar type

Predominant signs and symptoms are lack of muscle coordination (ataxia). Signs and symptoms may include:

Impairment of movement and coordination, such as unsteady gait and loss of balance

Slurred, slow or low-volume speech (dysarthria)

Visual disturbances, such as blurred or double vision and difficulty focusing your eyes

Difficulty swallowing (dysphagia) or chewing

General signs and symptoms

In addition, the primary sign of multiple system atrophy is:

Postural (orthostatic) hypotension, a form of low blood pressure that makes you feel dizzy or lightheaded, or even faint, when you stand up from sitting or lying down.

You also can develop dangerously high blood pressure levels while lying down.

People with multiple system atrophy may have other difficulties with body functions that occur involuntarily (autonomic), including:

Urinary and bowel dysfunction

Constipation

Loss of bladder or bowel control (incontinence)

Sweating abnormalities

A reduction in the production of perspiration, tears and saliva

Impaired control of body temperature, often causing cold hands or feet as well as heat intolerance due to impaired sweating

Sleep disorders

Agitated sleep due to "acting out" one's dreams

Abnormal breathing at night

Sexual dysfunction

Inability to achieve or maintain an erection (impotence)

Loss of libido

Cardiovascular problems

Irregular heartbeat

Psychiatric problems

Difficulty controlling emotions

When to see a doctor

If you develop any of the signs and symptoms associated with multiple system atrophy, see your doctor for an evaluation and diagnosis. If you've already been diagnosed with the condition, contact your doctor if new symptoms occur or if existing symptoms worsen.

Related

You're likely to start by seeing your family doctor, but you may be referred to a doctor who specializes in the diagnosis and treatment of conditions that affect the brain and nervous system (neurologist).

Here's some information to help you prepare for your appointment.

What you can do

Write down any symptoms you're experiencing, and for how long. Include all recent changes you've noticed in your physical or emotional well-being, even if they seem secondary to your main concern. For example, if you or your loved ones have noticed your moods shifting more quickly than in the past, share this with your doctor.

Make a list of your key medical information, including other conditions with which you've been diagnosed, and the names of any prescription and over-the-counter medications you're taking.

Write down key personal information, including any changes in your sex life, such as reduced interest in sex or difficulty getting an erection.

Find a family member or friend who can come with you to the appointment, if possible. Someone who accompanies you can help remember what the doctor says.

Write down the questions to ask your doctor.

For multiple system atrophy, some basic questions to ask your doctor include:

What is likely causing my symptoms?

Are there any other possible causes for these symptoms, such as Parkinson's disease?

How will you make a firm diagnosis?

What tests do I need?

What treatment options are available for multiple system atrophy?

What are the possible side effects of those treatment options?

How is my condition likely to progress?

Will treatment slow the progression of my illness or simply relieve symptoms?

Are there self-care steps that could help ease my symptoms?

How will you monitor my health over time?

Do I need to adjust the medications I'm taking for other health conditions?

Don't hesitate to ask any other questions that occur to you.

What to expect from your doctor

Your doctor is likely to ask you a number of questions, including:

What are your symptoms?

When did you begin having symptoms?

Do you feel lightheaded or dizzy when you stand up?

Have you ever fainted?

Do your symptoms include any emotional changes, such as swinging between laughter and tears?

Have you noticed any changes in your voice?

Have you been told that you snore loudly or have interrupted breathing while sleeping?

Have you had problems with bladder control?

Have you been constipated?

Have you had any sexual problems, such as reduced libido or impotence?

Do you have difficulty chewing or swallowing?

Do you have difficulty breathing?

Do you have any movement problems, such as slowness or poor coordination?

Do you have any family history of Parkinson's disease or other neurological disease?

Are you being treated for any other health conditions?

What you can do in the meantime

While you wait for your appointment, check with your family members to find out if any relatives have been diagnosed with neurological disorders such as Parkinson's or Huntington's disease. Multiple system atrophy (MSA) is not known to be an inherited condition, so a family history of a condition with similar symptoms may help your doctor rule out MSA.

Diagnosis of multiple system atrophy (MSA) can be challenging because there's no test that can make or confirm the diagnosis. At the same time, certain signs and symptoms of MSA — such as muscle rigidity and unsteady gait — also occur with other disorders, such as Parkinson's disease, making the diagnosis more difficult.

As a result, some people are never properly diagnosed, although doctors are increasingly aware of the disease and, thus, more likely to identify its symptoms.

If your doctor suspects multiple system atrophy, he or she will obtain a medical history, perform a physical examination, and possibly order blood tests and brain-imaging scans, such as an MRI, to determine whether brain lesions are present that may be triggering symptoms.

You may receive a referral to a neurologist or other specialist for specific evaluations that can help in making the diagnosis.

Tilt table test

One procedure that can aid in the diagnostic process is a tilt table test to help determine if you have a problem with blood pressure control. In this procedure, you're placed on a motorized table and strapped in place. Then the table is tilted upward so that your body is nearly vertical.

Throughout this maneuver, your blood pressure and heart rate are monitored. The findings can document not only the extent of blood pressure irregularities but also whether they occur with a change in physical position.

Tests to assess autonomic functions

Doctors may order certain other tests, to determine how your body is functioning. Tests to assess your body's involuntary functions may include:

Blood pressure measurement, lying down and standing

A sweat test to evaluate perspiration

Eye exam

Tests to assess your bladder and bowel function

Electrocardiogram to track the electrical signals of your heart

Nerve and muscular examination

If you have sleep irregularities, particularly if they involve interrupted breathing or snoring, your doctor may recommend having you evaluated in a sleep laboratory to determine if you have an underlying and treatable sleep disorder, such as sleep apnea.

There's no cure for multiple system atrophy. Management of the disease involves treating signs and symptoms to make you as comfortable as possible and to maintain your body functions and capabilities.

To treat specific signs and symptoms, your doctor may recommend:

Medications to raise blood pressure. Medications such as the corticosteroid fludrocortisone can increase your blood pressure by leading to more retention of salt and water. This drug, which is a steroid, is often prescribed on a twice-a-day regimen.

Other medications to increase standing pressure, such as midodrine (Orvaten), are available and can raise your blood pressure quickly; however, midodrine has been shown to elevate pressure while lying down, which can increase the risk of stroke in some people.

The FDA has recently approved droxidopa (Northera) for treating orthostatic hypotension. The most common side effects of droxidopa include headache, dizziness and nausea.

Medications to reduce Parkinson's-like signs and symptoms. Certain anti-Parkinson's medications, such as combined levodopa and carbidopa (Parcopa, Sinemet), can be used to reduce Parkinson's-like signs and symptoms, such as stiffness, balance problems and slowness of movement, as well as improve an overall feeling of well-being.

However, not everyone with multiple system atrophy responds to Parkinson's drugs, and the effectiveness of these medications may decline after a few years of therapy.

Impotence drugs. Impotence can be treated with a variety of drugs, such as sildenafil (Revatio, Viagra), designed to manage erectile dysfunction.

Steps to manage swallowing and breathing difficulties. If you have difficulty swallowing, try eating softer foods. If swallowing or breathing becomes increasingly problematic, you may need a feeding tube or breathing tube inserted surgically to manage the problem. Late in the disease process, you may require a tube (gastrostomy tube) that delivers food directly into your stomach.

Bladder care. If you're experiencing bladder control problems, medications can help in the earlier stages. Eventually, when the disease becomes advanced, you may need to have a soft tube (catheter) inserted permanently to allow you to drain your bladder.

A physical therapist can help you maintain as much of your motor and muscle capacity as possible as the disorder progresses. A speech-language pathologist can help you learn to improve or maintain your speaking ability.