Some other questions related to Unlimited Blade Works:1. Can Strike be used to prevent the saves? If so, does it apply to all the saves on the first turn, or just one of them? (I have no reason to think it would last until the second turn, but if I'm wrong, please say so).

1. They're simultaneous so they would all count as first, and no wouldn't last to the second turn since it would be a new batch of saves.

Just to clarify, Strike only works on the first attack with maneuvers like Multi-Target, right?

No, for something like Multi-Target, it would benefit all of them. Just like firing a MAP weapon or an All weapon on the SRW games that have a squad system.