Background & Aim: Preventive and control policies of major beta-thalassemia focus on couples with minor thalassemia. Therefore, this study aimed to evaluate the life satisfaction in couples with minor thalassemia to examine the preventive and control policies of major beta-thalassemia.Material & Methods: This is a descriptive research. The research population consists of all couples who were informed about their status before engagement and have married in Bojnourd since 2001 (62 samples by census method). The survey tools were short life satisfaction form and SWLS questionnaire. Data were analyzed by SPSS software using frequency test and linear correlation.Results: The results showed that 67.7% of couples with minor thalassemia participated in this study have reported low levels of life satisfaction (dissatisfied and slightly dissatisfied). Also, there was a significant statistical relationship between life satisfaction and parameters like the number of children and marriage date of couples (P value=0.00); but there was no relationship between life satisfaction and age (P value= 0.547) and sex (P value= 0.947).Conclusion: The results of this study confirm the psychological problems despite the increase and development of services throughout the country. Since the country's program for preventing major beta-Thalassemia is related to marriage, fertility and the management of them, consultation will play a certain role in advancing the objectives of the program's goal.