Tylenol Cold And Flu Severe (Acetaminophen / Phenylephrine / Dextromethorphan / Guaifenesin) is an okay combination medicine that relieves cold and flu symptoms, so make sure you really need all of its ingredients.

Relieves cold and flu symptoms.

Alka-Seltzer Plus Day Cold And Flu (Acetaminophen / Dextromethorphan / Phenylephrine) is good for multiple cold symptoms, but it's more medicine than you need if you only have one symptom.

Upsides

Tylenol Cold And Flu Severe (Acetaminophen / Phenylephrine / Dextromethorphan / Guaifenesin) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have a stuffy nose, a cough, fever, and pain.

The decongestant (phenylephrine) has fewer side effects than other decongestants like pseudoephedrine. It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.

The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than other pain medications like aspirin or ibuprofen.

Alka-Seltzer Plus Day Cold And Flu (Acetaminophen / Dextromethorphan / Phenylephrine) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have a stuffy nose, a cough, fever, and pain.

The decongestant (phenylephrine) has fewer side effects than other decongestants like pseudoephedrine. It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.

The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than to other pain medications like aspirin or ibuprofen.

Downsides

If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.

Phenylephrine doesn't last as long as other oral decongestants like pseudoephedrine.

You shouldn't use it if you have high blood pressure.

To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.

Two of the medications in this product could potentially work against each other. Guaifenesin makes mucus easier to cough up, while dextromethorphan stops you from coughing.

If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.

Phenylephrine doesn't last as long as other decongestants like pseudoephedrine.

You shouldn't use it if you have high blood pressure.

To avoid hurting your liver, you need to keep track of the total amount of acetaminophen (APAP) you are taking since it is a very common ingredient in pain and cold/flu combination medicines.