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Human Methyltransferase Like 3 (METTL3) Interaktionspartner

The role of METTL3 in pancreatic cancer cells drug resistance and radiation resistance.METTL3 was associated with mitogen-activated protein kinase cascades, ubiquitin-dependent process and RNA splicing and regulation of cellular process.

METTL3 is soluble and inactive while the catalytic center of METTL14 (zeige METTL14 Proteine) is degenerated and thus also inactive. In addition, the C-terminal RGG repeats of METTL14 (zeige METTL14 Proteine) are required for METTL3/14 activity by contributing to RNA substrate binding.

data define METTL3 as a regulator of a chromatin-based pathway that is necessary for maintenance of the leukaemic state and identify this enzyme as a potential therapeutic target for acute myeloid leukaemia

loss of METTL3 leads to increased levels of phosphorylated AKT (zeige AKT1 Proteine), which contributes to the differentiation-promoting effects of METTL3 depletion. Overall, these results provide a rationale for the therapeutic targeting of METTL3 in myeloid leukemia (zeige BCL11A Proteine)

The structure reveals the heterodimeric architecture of the complex and donor substrate binding by METTL3. Structure-guided mutagenesis indicates that METTL3 is the catalytic subunit of the complex, whereas METTL14 (zeige METTL14 Proteine) has a degenerate active site and plays non-catalytic roles in maintaining complex integrity and substrate RNA binding.

For the methylation of adenosine in RNA, Mettl3 is the catalytically active subunit, while Mettl14 (zeige METTL14 Proteine) plays a structural role critical for substrate recognition.

METTL3 enhances mRNA translation through an interaction with the translation initiation machinery in lung adenocarcinoma cells.

data define METTL3 as a regulator of a chromatin-based pathway that is necessary for maintenance of the leukaemic state and identify this enzyme as a potential therapeutic target for acute myeloid leukaemia

this study identifies Mettl3, an N(6)-methyladenosine (m(6)A) transferase, as a regulator for terminating murine naive pluripotency.

METTL3 Protein Überblick

Protein Überblick

This gene encodes the 70 kDa subunit of MT-A which is part of N6-adenosine-methyltransferase. This enzyme is involved in the posttranscriptional methylation of internal adenosine residues in eukaryotic mRNAs, forming N6-methyladenosine.