Maternal exposure to air pollution early in pregnancy linked to preterm, low birth weight babies

Exposure to air pollution early in a pregnancy could increase risk for preterm birth and low birth weight, according to a study led by researchers at NYU School of Medicine, and published on July 27 in Environmental Health Perspectives.

The study, conducted in mice, found that exposure to air pollution during the equivalent of the first or second trimester in humans was linked to more negative birth outcomes than exposure later in pregnancy.

Researchers studied the effects of fine particulate air pollution, which is made up of particles less than one ten-thousandth of an inch in diameter, or PM2.5. Inhalable and almost invisible to the eye, this type pollution comes from car exhaust, coal-fired power plants, and other industrial processes. PM2.5exposure has previously been linked to risk for asthma and heart disease.

According to the US Centers for Disease Control and Prevention, preterm birth and low birth weight increase risk for vision and hearing problems, learning problems and even death.

Using PM2.5 levels comparable to those found in highly-polluted urban environments, researchers examined obstetric outcomes based on exposures during different stages of pregnancy in mice. The findings, according to the study's authors, could have both implications for physicians as they advise women during pregnancy, as well as for air pollution policy.

"This first study of this problem in mice adds to the growing body of evidence that inhalation of particulate matter from implantation through the second trimester of pregnancy is potentially dangerous," says lead author and investigator Jason Blum, PhD, MS, assistant professor in the Department of Environmental Medicine at NYU School of Medicine.

Implications for Clinical Care and Policy

Past studies had linked high levels particulate matter exposure to low birth weight, but impact of the timing of maternal exposure on birth weight had been debated. The new findings suggest that exposure during the first two trimesters has the greatest affect, say the study authors.

In the study, pregnant mice were randomly assigned to one of two groups-- one exposed to filtered air and a second to concentrated PM2.5. The mice exposed to particles were also randomly assigned for exposure during one of four gestational periods designed to mirror the stages of human pregnancy: period 1(0.5-5.5 days); period 2(6.5-14.5 days); period 3(14.5-16.5 days); or period 4(0.5-16.5 days).

Researchers measured both the duration of pregnancy and birth weight of the offspring to identify the effects of concentrated PM2.5 over the time periods. Their results show that exposure to air pollution during period one resulted in preterm birth for about 83 percent of exposed mouse litters. Similarly, exposure to PM2.5 from conception to the end of the second trimester--periods one, two and three--resulted in an 11.4 percent decrease in birth weight for 50 percent of the litters.

Exposure during the first and second trimester also came with decreased body length, decreased placental weight, and decreased anogenital distance, which can reflect abnormal hormone levels, says Blum.

"These findings could lead physicians to advise women to avoid high pollution areas or use air filtration systems during the early stages of pregnancy," says senior study author Judith Zelikoff, PhD, a professor in the Department of Environmental Medicine at NYU School of Medicine. "With preterm birth and low birth weight having such serious health consequences, the need for further research in this area is greater than ever."

Samuel Lesko has more than 20 years experiences in running AFM over variety of applications.
After obtaining a PhD at Burgundy university on colloidal force measurement in cement, he started his career at Veeco Instruments as French Applications Scientists before to continue on supporting Bio Applications AFM European wide. He is since 2007 Applications manager for Europe, Middle East and Africa. Recently, his position expanded to Latin America.

There's a continued drive towards making in vitro assays ever more translational towards in vivo models and ultimately the clinic. This ties in with the resurgence of phenotypic screening and is a response to the perceived poor translation of the traditional simple cell-based assays, often developed to study just single protein targets.

Paul Morris is the Director of Professional Advancement for Specsavers Opticians in the UK and Ireland. The role involves furthering clinical scope, professional services, standards, training and forming future strategy for the group. He previously held the role of Director of Optometry Advancement.

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