Frogger (voiced by Bob Sarlatte) is an ace reporter of the swamp who works at the Swamp Gazette. He and his friends Shellshock "Shelly" Turtle (voiced by Marvin Kaplan) and Fanny Frog (voiced by B.J. Ward) go out in search of crazy stories (sometimes about human behavior) to publish in the swamp's newspapers. Frogger also has to deal with his gruff boss and editor-in-chief Tex Toadwalker (voiced by Ted Field, Sr.). As in the game, he often gets flattened or has an encounter with an alligator.

Donkey Kong (voiced by Soupy Sales) has escaped from the circus. He is on the lam, and Mario (voiced by Peter Cullen) and Pauline (voiced by Judy Strangis) are chasing the ape. As with the original game, Donkey Kong will often grab Pauline, and Mario has to save her. Plots typically centered on them encountering crime with the villains conning the slow-witted Donkey Kong into doing their work and Mario and Pauline exposing the truth. After Mario and Pauline reveal the truth to Donkey Kong, the three of them team up to stop the antagonists' plans followed by Donkey Kong evading Mario and Pauline again.

In a 1950s inspired world set in the town of Q*Berg, a teenage fur-covered creature named Q*bert (voiced by Billy Bowles), his girlfriend Q*Tee (voiced by Robbie Lee), his brother Q*Bit (voiced by Dick Beals), and his friends Q*Ball (voiced by Frank Welker), Q*Val (voiced by Robbie Lee), and Q*Mongus (voiced by Frank Welker) must deal with the resident bullies Coily, Ugg, Wrong Way (all three voiced by Frank Welker), and Viper (voiced by Julie McWhirter). Features both "block-hopping" scenes, "swearing" bubbles and occasional flying disc, all from the original game. New to the cartoon was Q*bert's use of "slippy-doos", a black ball projectile which he loaded and fired through his nose, producing an oil slick wherever the balls splattered. Slick and Sam (both voiced by Frank Welker) are also featured.

Donkey Kong Jr. (voiced by Frank Welker) is sad to find that his father is running away from Mario and the circus. He befriends a greaser nicknamed "Bones" (voiced by Bart Braverman) who has a motorcycle and offers to help Junior by finding his dad together. Donkey Kong Jr's catchphrase is "Monkey muscle!", which he tells to himself and Bones to inspire self-confidence. Bones often serves as the voice of reason when Donkey Kong Jr. bites off more than he can chew.

Space Ace (voiced by Jim Piper) is the always smiling self-confident champion of the "Space Command", whereas when always 'wimping out' to Dexter (voiced by Sparky Marcus) after being hit by the Infanto-Ray, he becomes clumsy and weak. With officer Kimberly (voiced by Nancy Cartwright), he works for Space Marshall Vaughn (voiced by Peter Renaday) to keep the peace in the universe. They fight the evil alien commander Borf (voiced by Arthur Burghardt) and keep him from invading Earth. Ace and Kim try to keep his 'wimping' situation secret and pretend that Dexter is Kim's little brother.

Again, as with Donkey Kong, Ruby-Spears took artistic license; in the video game, Dexter had certain chances to revert to Ace, his full-grown self, whereas in the cartoon the Ace/Dexter phases seemed to happen on their own and at often inconvenient times for the hero.

It was aired late night on Cartoon Network in the late 1990s, and segments have been shown between programs on Boomerang.

Warner Archive announced via their Facebook page that Saturday Supercade will be released through their made-on-demand DVD program. However, due to rights issues, some segments may not be able to appear. Currently they are researching the project and have no set release date.[1]

On November 3, 2015, Sony Pictures Home Entertainment released The Best of Q*Bert on DVD in Region 1.[2] The 1-disc collection features 17 of the 19 episodes of the series. This is a Manufacture-on-Demand (MOD) release, available exclusively in the US via Amazon.com and their CreateSpace MOD program.