Nature runes are runes that are used for transmutation spells. Members with a Runecrafting skill of 44 or greater can craft nature runes from Pure Essence at the Nature altar. Members with 91 or greater runecrafting always craft two nature runes per essence; those with between 44 and 90 runecrafting have a chance at crafting either one or two nature runes per pure essence, with the probability of two increasing with runecrafting level. Crafting nature runes yields 9 runecrafting experience per essence (or 18 experience at the Ourania rune altar). Nature runes are one of the five most traded items in the Grand Exchange, especially because of the demand for High Alchemy.

Acquiring

Runecrafting

The teleport to the Graahk hunter area on Karamja offers a very fast way to make Nature runes. This can be accessed by left-clicking 'interact' on the Spirit Graahk, then clicking "Teleport". After teleporting, it takes about 30 seconds to reach the Nature altar, which is many seconds faster than the average time it takes to reach the nature altar using the Abyss. With four Runecrafting pouches, complete trips to the Nature altar can be done in under 60 seconds, allowing over 3000 pure essence to be crafted into nature runes per hour. Some players also choose to omit the small pouch and use only three pouches, doing only two craftings and two bankings per run to do runs faster at a cost of slightly less essence per run, resulting in more essence being crafted in the long run. Each Spirit Graahk lasts 49.5 minutes before a new pouch is needed.

For members, a good source of nature runes through drops are Basilisks; They will drop from 15 to 37 nature runes at a time. They have a higher combat level than dark wizards, and a combat level of 70 is recommended to make their demise easier. A Slayer level of 40 is required to kill them, as is a mirror shield. Many other slayer monsters are good souces of nature runes too; some even better than Basilisks.