A recent review of the study by the National Institute of Allergy and Infectious Diseases (NIAID)
Data and Safety Monitoring Board (DSMB) found that in antiretroviral treatment-na´ve patients, a
combination preparation of three nucleoside analogues, Trizivir«, was inferior to two other
efavirenz-containing treatment regimens being evaluated in the study. The data met pre-specified
guidelines for stopping this one arm of the study based on virologic failure. There were no
concerns about the toxicity of the study drugs

The Annual Meeting of the Medical Library Association (MLA) will be held May 2-7, 2003 in San Diego.
Attendees are invited to visit the NLM exhibit booth (May 3-6) to meet NLM staff and see NLM's Web products.
The NLM Theater at the booth will feature demonstrations and tutorials on a wide variety of topics, including:
PubMed, LinkOut for Libraries, PubMed Central, the NLM Gateway, MedlinePlus, the NLM WebClassification,
LocatorPlus/Web Authority, Unified Medical Language System, TOXNET, Gene Indexing and more.

CE Classes
While at the meeting in San Deigo, consider taking a MLA continuing education class taught by NLM staff.
For example:

Friday, May 2, half-day course

Adventures in Public Health (Public Health 101)

Course #321

Saturday, May 3, full day course

Digging In: Hands-on Experience with NCBI's Molecular Databases

Course #345

Saturday, May 3, half-day course

Introduction to Reference Sources in the History of the Health Sciences

Course #481

Wednesday, May 7, half-day course

HIPAA: What Health Sciences Librarians Need to Know

Course #198

Further course details are available at [Note: This link was removed because it is no longer relevant.],
or contact MLA at (312) 419-9094.

Friends of the NLM Reception on Sunday, May 4, 7:00 p.m. - 9:00 p.m. Further details and ticket information
are available at [Note: This link was removed because it is no longer relevant.], or contact MLA at (312) 419-9094.

The article was indexed using NLM's Web-based Data Creation and Maintenance System
(DCMS) which was implemented in late 2000. When the 10 millionth citation was indexed
on July 10, 1999, NLM was still using the mainframe computer-based indexing system
called AIMS (Automated Indexing and Management System) and PubMed was searched at
the rate of 16 million searches per month and updated with MeSH-indexed MEDLINE
citations once per week. Approximately 30% of data entry came from electronic
submissions and NLM indexed a total of about 434,000 citations from 4,007 journals
by the close of that Fiscal Year. MEDLINE was licensed by 57 organizations.

Today, PubMed is searched at a rate of more than 30 million searches per month and updated
with MeSH-indexed citations 5 times per week. More than 65% of data entry comes from
electronic submissions and NLM reached the all time high of about 502,000 indexed
citations from 4,538 journals at the close of Fiscal Year 2002. MEDLINE is leased
by about 170 organizations (the majority of which are mining the data for research
purposes). What a difference a few years can make!

The cow and Caenorhabditis elegans have been added to the list of LocusLink organisms.
Initially there were five organisms in LocusLink - human, mouse, rat, fruit fly, and zebrafish.
HIV-1 was added on May 30, 2002. Cow (Bos taurus) was added on December 2, 2002 and
Caenorhabditis elegans, a nematode, was added on December 31, 2002.

In July 2002, NCBI announced the availability of new programming for the
Entrez Utilities (E-Utilities) and
informed utility users that they should convert URLs to the
new format by the end of 2002.

NCBI will phase out the old utilities completely in June 2003. This may affect customers
of some products such as EndNote®,
ProCite®, and Reference Manager®.
Please contact
user support for your respective product if you have questions. Questions concerning the use
of E-Utilities can be sent to: eutilities@ncbi.nlm.nih.gov.

If you have manually created links to PubMed that contain the string: /htbin-post/,
these should be changed to follow the specifications provided on the page,
Linking to
PubMed and other Entrez Databases.
These changes must be in place prior to June 2003.

The National Library of Medicine announces release of the new Partners in Information Access
for the Public Health Workforce Web site. This site is one result of a collaboration of U.S. government
agencies, public health organizations and health sciences libraries. The goal of both the Partners project and
the Partners site is to provide the public health workforce with timely, convenient access to information resources.
See the announcement about the new Web site and spend some time discovering the public health
information and resources available from the Partners in Information Access Web site at:
http://phpartners.org.

A new version of DOCLINE was released on March 3, 2003. The highlight of the release was the addition
of Mexico as a new region, allowing eligible Mexican libraries to become full DOCLINE
participants. Please review the DOCLINE 1.5
Release Notes for details.

NLM is proud to announce that March 19, 2003 at 11:09am Eastern Time
the DOCLINE system processed its 10 millionth
request since the Web version was released in July 2000. The 10 millionth
request was entered by a Loansome Doc patron. The request was filled by the
user's hospital library in San Diego, California in just over 2 hours.