While plans for most of the 73-block East Midtown district — roughly between Third and Fifth Avenues and from East 39th to East 57th Street — won’t be drawn up for another year or more, Mayor de Blasio and Planning Commissioner want to kick-start one major project much sooner.

A new, 65-story office tower would rise on Vanderbilt Avenue between 42nd and 43rd streets. TD Bank, now based in New Jersey, would move its headquarters into the skyscraper to be built by the SL Green company.

It would be the first large new building in the area in years. Current zoning severely restricts building sizes, and in much of the area, existing structures could not be replaced even with ones of the same size. Buildings in the district are an average 70 years old.

The Vanderbilt Avenue project still must go through the city’s public review process.