AbstractObjective: POTS is a heterogeneous disorder of the autonomic nervous system that can result from multiple etiologies. An increased prevalence of vitamin B12, vitamin D 25-OH and iron deficiencies has been observed in patients with POTS.

This study examined the prevalence of vitamin B1 deficiency and assessed response to vitamin B1 supplementation in the deficient POTS patients.

Methods and Results: Medical records of 65 consecutive patients with POTS evaluated at our clinic were reviewed. In this cohort (mean age 32, range 13–54 years; 89% female), 6% had vitamin B1 deficiency, and one of four deficient patients experienced significant improvement of POTS after oral vitamin B1 supplementation.

Conclusion:A small subset of patients with POTS may have vitamin B1 deficiency. Testing for vitamin B1 deficiency and correcting the deficiency is recommended.

I wonder if this is relevant for my case as one time when I was in hospital the hospital started gave me thiamine injection(s), I assume they did this as they must of found me to be deficient. (I never found out why they gave me at least one injection of this).

I have been found to have those other deficiencies too (with ferritin and D)

Is B5 (pantothenic acid/pantethine) deficiency a symptom of POTS? I've seen a study that suggested that deficiency causes orthostatic hypotension but I can't find enough research to support increasing my dose. I take 450mg pantethine and I'm scared to increase it because so many supplements lower my blood pressure or cause orthostatic hypotension. When I take pantethine it makes me pee a lot and that doesn't seem good for aldosterone/retaining salt.

Ann Louise Gittleman swears that high dose pantethine (2 grams a day) solves low blood pressure and Doctors Lam and Wilson swear by it for adrenals.