RasGAP protein, C-terminal (IPR000593)

Short name:
RasGAP_C

Overlapping homologous superfamilies

None.

Domain relationships

None.

Description

This domain can be found in the C terminus of the IQGAP family members, including human IQGAP1/2/3, S. cerevisiae Iqg1 and S. pombe Rng2. Some members function in cytoskeletal remodelling [PMID: 20335501]. Human IQGAP1 is a scaffolding protein that can assemble multi-protein complexes involved in cell-cell interaction, cell adherence, and movement via actin/tubulin-based cytoskeletal reorganization [PMID: 11112700]. IQGAP1 is also a regulator of the MAPK and Wnt/beta-catenin signaling pathways [PMID: 20335501]. Iqg1 and Rng2 are required for actomyosin ring construction during cytokinesis [PMID: 11854008, PMID: 9635188].