OECD SIDS 5. TOXICITY

DL-LACTONE

ID: 79-50-5 DATE: 18.01.2006

Test substance:

effects. In the 10% test substance/FCA treatment croup, 5/10 animals showed grade 2 erythema, 1/10 showed grade 1 erythema and the remaining 4/10 showed necroses with diameters of 2, 3, 3 and 4 mm; in the 5 FCA-only controls, 3/5 showed grade 1 erythema and 2/5 showed grade 2 erythema. The skin effects caused by the epidermal exposure during the induction phase are summarised as follows: 9/10 test animals showed no effects at all while the remaining 1/10 showed grade 1 erythema (this animal had shown grade 1 respectively grade 2 erythema on intradermal respectively epidermal induction), while all 5 control animal showed no effect. Main Study, Challenge No skin reactions were evident after the challenge exposure in both experimental and control animals. No mortality occurred and no symptoms of systemic toxicity were observed in the animals of the main study. Body weights and body weight gain of experimental animals remained in the same range as the controls over the study period. dl-Lactone from DSM (until 2003 Roche) Dalry, sample no.