INTRODUCTION: Capacitated spermatozoa initiate fertilization by binding to the carbohydrate sequences on the zona pellucida (ZP). Defective spermatozoa-ZP binding leads to subfertility, and is an important cause of reduced fertilization in assisted reproduction. The regulation of spermatozoa-ZP interaction is unclear partly due to lack of knowledge on the identity of the ZP receptor on spermatozoa. With the use of ultrasensitive mass spectrometry, we have identified …

INTRODUCTION: Capacitated spermatozoa initiate fertilization by binding to the carbohydrate sequences on the zona pellucida (ZP). Defective spermatozoa-ZP binding leads to subfertility, and is an important cause of reduced fertilization in assisted reproduction. The regulation of spermatozoa-ZP interaction is unclear partly due to lack of knowledge on the identity of the ZP receptor on spermatozoa. With the use of ultrasensitive mass spectrometry, we have identified …

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dc.language

eng

en_US

dc.publisher

Oxford University Press. The Journal's web site is located at http://humrep.oxfordjournals.org/

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dc.relation.ispartof

Human Reproduction

en_US

dc.subject

Medical sciences

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dc.subject

Obstetrics and gynecology medical sciences

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dc.subject

Endocrinology pharmacy and pharmacology

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dc.title

Identification of sialyl-Lewis(x) (SLEX)-binding protein on human spermatozoa and its role on sperm-zona pellucida interaction