The current study compares hippocampal atrophy to
episodic memory measures and to diffusion measures of the fornix in patients
with Multiple Sclerosis. Though we find no differences in overall hippocampal
volume between patients and controls, measures of white matter integrity in
the fornix and a measure of episodic memory were related to hippocampal
volume only in patients. This bolsters the argument that hippocampal
pathology contributes to memory loss in MS.