Neurofibroma is a benign lesion of unknown origin that may occur in the peripheral nerve, soft tissue, skin or bone. It occurs as a solitary lesion more commonly than as a multiple lesion or in neurofibromatosis (NF-1 or von Recklinghausen's disease). NF-1 is characterized by nuerofibromas, acoustic nerve schwannomas, Lisch nodules and cafe-au-lait spots.
Solitary lesions most commonly form in the brachial plexus, lumbrosacral plexus, peripheral nerve or spinal nerve.
They are most commonly present from age 20 to 30.
A Neurofibroma often arises as a superficial painless mass in the dermis.On plain X-ray, it may appear as an intraosseous lytic lesion (if the neurofibroma involves the bone).