SNP rs1800437, located in the coding region of the GIPR gene and known as Glu354Gln, shows a marginal association with cardiovascular disease (CVD) in a study of ~200 patients from a Dutch population. Heterozygotes are reported to be at lower risk for CVD, with an odds ratio of 0.72 (CI: 0.52 - 0.97, p=0.03). However, no significant association was seen for homozygous carriers of the minor allele. [PMID 17624916]