Product Details

Purity

>98% as determined by SDS-PAGE and HPLC.

Endotoxin

Less than 1.0 EU/μg as determined by LAL method.

Activity

Fully biologically active when compared to standard. The ED50 as determined by the ability of the immobilized protein to support the adhesion of the A549 human lung carcinoma cells is less than 5.0 μg/ml, corresponding to a specific activity of >200 IU/mg.

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Lead Time

Basically, we can dispatch the products out in 5-10 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Target Data

There was no evidence that serum CC16 levels played a role in recurrent wheezing and a positive asthma predictive index in pre-school children PMID: 29685782

Data suggest that the increase in plasma club cell protein (CC16) CC16 following inhaled allergen as a biomarker of epithelial dysfunction. PMID: 28862880

We propose that increased CC-16 levels is a marker of lung inflammatory response that associated with ventilatory insufficiency are related to impending respiratory failure, not fully predicted by conventional respiratory tests PMID: 28967121

Studied serum CC16 levels in The serum CC16 levels in Acute respiratory distress syndrome (ARDS) and non-ARDS patients; found CC16 to be were significantly higher in ARDS patients than that in non-ARDS patients. PMID: 28548310

There were associations between urinary CC16 and arsenic concentration in soil, water, house dust, and dust loading. In multiple analyses, only the concentration of arsenic in soil was associated with urinary CC16 levels after accounting for other factors. PMID: 27223295

findings demonstrate that CC16 is upregulated in IPF patients suggesting that may participate in its pathogenesis. PMID: 27977812

The G38A CCSP gene polymorphism may alter either the production of the protein and/or its activity in chronic obstructive pulmonary disease. PMID: 27496897

Lung-specific (CC-16) and novel (RelB) biomarkers are associated with systemic cardiovascular changes over time. CC-16 can predict subsequent exacerbations in subjects with severe COPD and may be an important biomarker of pulmonary and systemic stress in COPD. PMID: 26914709

The serum concentration of CC16 was significantly higher in patients with lung fibrosis. PMID: 25244495

lower levels of urine CC16 and lung function in patients with asthma than in those patients without asthma. CC16 in urine may be a useful tool or biomarker for investigating lung epithelium integrity among children with asthma or lung injury. PMID: 26108072

In chromium-exposed workers, blood levels of CC16, and CC16/SP-D were lower than in controls. Positive relationships were shown between CC16 or CC16/SP-D and indicators of lung function. PMID: 25851191

KL-6 levels were higher and CC16 levels were lower in infants with poor neurodevelopmental outcome compared with those infants who had favourable neurodevelopmental outcome. PMID: 25631862

CC16 may play an important protective role in cigarette smoke-related diseases. PMID: 25635997

A meta-analysis indicated that the CC16 gene A38G polymorphism is not associated with the risk of asthma. PMID: 25743006

Serum CC-16 is associated with disease progression in chronic obstructive pulmonary disease (COPD). However, the absence of CC-16 does not appear to modify the risk of cigarette-related COPD in mice. PMID: 24245748

Acute exposure to smoke induces injury at the alveolar level, which results in a transient increase of CC16 in serum of exposed subjects. PMID: 23258467

These results suggest that the CC16 A38G polymorphism may play a role in asymptomatic airway hyper-responsiveness and contribute to the development of late-onset asthma. PMID: 24125144

The SCGB1A1 +38A/G polymorphism is a risk factor for asthma. [Meta-analysis] PMID: 23820082

urinary CC16 may be a useful biomarker of increased lung epithelial permeability among female non-smokers; further work will be required to evaluate its applicability to males PMID: 22805990

Clara cell secretory protein expression changes is a relevant marker in the development of bronchiolitis obliterans patients with lung transplantation. PMID: 22883104

Overview of CC16 in pathophysiology of and as a biomarker in chronic obstructive pulmonary disease. PMID: 23030587

A Genome wide association study for COPD biomarkers on subjects with COPD found 2 discrete loci affecting CC16, one near the CC16 coding gene (SCGB1A1) on chromosome 11 and one approximately 25Mb away from SCGB1A1, identified in expressed sputum. PMID: 23144326

Exercise caused an increase in urinary excretion of CC16 in all subjects (P < 0.001), but this rise in CC16 was blunted following inhalation of warm humid air. PMID: 21799131

demonstration that cc-10 is differentially expressed in infants with iRDS may point the way towards one possible mechanism that potentially involves modifications of the protein structure with its anti-inflammatory and surfactant protective function PMID: 22613976

CC10 G+38A variant may contribute to the severity of asthma and lower level of steroid responsiveness. PMID: 22788242

These results indicate that CC10 gene transfer may inhibit airway inflammation through suppressing the activation of NF-kappaB. PMID: 22558282

Serum Clara cell secretory protein levels were characterized by an early postnatal surge. This apparent gestation-influenced surge may represent an initiation of a protective cascade against postnatal lung injury during extrauterine adaptation. PMID: 21952535

Single-nucleotide polymorphism in the CC10 gene (A38G) does not seem to be involved in the severity of respiratory syncytial virus infection or wheezing. PMID: 21767304

The effect of G38A may be apparent under stimulation as sex steroids or infections, and homozygotes of the G38A mutation cannot produce sufficient UG in response to stimulation and may be predisposed to IgA nephropathy, especially in childhood. PMID: 11774099

Role of uteroglobin G38A polymorphism in the progression of IgA nephropathy in Japanese patients. PMID: 11967037

is a regulator of the inflammatory process in respiratory diseases PMID: 12014016

Lys 43 and Asp 46 in rhUG are critical residues for the sPLA2-inhibitory activity of UG PMID: 12127976

In IgA nephropathy, circulating UGB is not reduced and is even increased in IgA-Fn complexes, suggesting a feedback mechanism to downregulate the formation and circulation of IgA1-Fn complexes. PMID: 12200800

COUP-transcription factors may play a pivotal role in cell specificity of the human CC10 gene by inhibiting its expression in nonpermissive cells PMID: 12204889

CC16*A38G single-nucleotide polymorphism influences bronchial hyperreactivity and might be a genetic determinant of asthma severity in German children. PMID: 12642831

results suggest that rP1 inhibits platelet aggregation by participation in the actin polymerization through which store mediated calcium entry is mediated PMID: 12927696

G38A polymorphism in the CC10 gene may influence protein expression and be associated with the development of progressive sarcoidosis PMID: 14551164

The presence of UG significantly correlated with the expression of estrogen receptor alpha and Progesterone rseceptor in endometrial cancer. PMID: 14719079

uteroglobin expression is regulated by progesterone in the normal endometrium but regulation by progesterone receptor is lost in endometrial hyperplasia and carcinoma according to acquirement of tumorigenesis PMID: 14735466

Uteroglobin G38A polymorphism had no association with the development of IgA nephropathy. PMID: 14990020

Uteroglobin is an essential component of a novel innate homeostatic mechanism in the mammalian airways to repress allergen-induced inflammatory responses. PMID: 15148333

These data provide new insights into the role of CC-10 in lung diseases and the possibility that the CC-10 concentration in serum could be a new marker indicating the severity of bronchial asthma. PMID: 15467329

uteroglobin plays important roles in maintaining homeostasis in organs that are vulnerable to inadvertent stimulation of FP-mediated inflammatory response by inhibiting the prostaglandin F2alpha receptor PMID: 16061484

Given that inflammation may lead to functional compromise, these data suggest that early intervention with rhCC10 may enhance SF therapy. PMID: 16081627

Subjects with CC16 38AA were more likely to have moderate or severe acute asthma. PMID: 16387800

CC10 is detectable in the blood of newborn infants, and a production surge occurs at birth; surge is more pronounced in term infants and may confer them with superior extrauterine pulmonary protection compared with preterm infants PMID: 16690962

These results do not support a role for UG in susceptibility to childhood Henoch-Schonlein purpura. PMID: 16703373

Uteroglobin induces the development and cellular proliferation of the mouse early embryo. PMID: 17094107

The genetic polymorphism in CC16 38 A/G is not associated with susceptibility to COPD in a southern Chinese population of Han nationality. PMID: 17207022

Uteroglobin is present in the human fallopian tube as a secretory protein and appears to be involved in immunosuppressive responses in the fallopian tube. PMID: 17531233

Serum Clara cell protein 16(CC16) concentrations decreased in silica-exposed miners and may be a useful biomarker for early diagnosis of silicosis. PMID: 17693780

study found that infant frequent wheezing is associated with the CC10 G+38A polymorphism and lower CC10 levels but not infant atopy PMID: 17716718

Study provides evidence for the first time for AF-1 binding with uteroglobin(UG)-binding protein, and preliminarily characterized UG-binding protein as a point downstream of AF-1 in mediating ERK phosphorylation. PMID: 17928103

Uteroglobin interacts with the heparin-binding site of fibronecti(Fn) and propose that small molecules competing for interaction with this site may reduce the level of circulating Fn-IgA complexes in immunoglobulin A (IgA)-nephropathy. PMID: 18243143

Higher levels of the anti-inflammatory protein CC10 are associated with improvement in bronchial dysplasia PMID: 18316584

CC10 may take part in the pathogenesis of CRS and correlates with disease severity. Different cytokines can regulate CC10 expression in nasal mucosa differentially through modulating mRNA stability and certain transcriptional factors expression. PMID: 19076932

SCGB1A1 A38G may play a role in the development and persistence of the asthma phenotype in childhood. PMID: 19128353

propose that CC16 may down-modulate the entry of human eosinophils and neutrophils into the airways during inflammation in the lung PMID: 19132521

Data show that comparing with similar fusion proteins in which uteroglobin was not used, the use of uteroglobin improved properties of solubility and stability. PMID: 19632988

CC10 was the most down-regulated gene in human nasal polyp tissues studied by means of DNA microarray PMID: 15480316

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Subcellular Location

Secreted

Protein Families

Secretoglobin family

Tissue Specificity

Clara cells (nonciliated cells of the surface epithelium of the pulmonary airways).