Younger brother of the comedian and actor John Belushi, he appeared in a number of successful movies in the mid to late 1980s and early 1990s, including Trading Places (1983), The Man with One Red Shoe (1985), About Last Night (1986), Jumping Jack Flash (1986), Little Shop of Horrors (1986), Only the Lonely (1991), Wag the Dog (1998) and Return to Me (2000).