Sleep deprivation is associated with considerable social, financial, and health-related costs, in large measure because it produces impaired cognitive performance due to increasing sleep propensity and instability of waking neurobehavioral functions.

Chronic sleep-restriction experiments - which model the kind of sleep loss experienced by many individuals with sleep fragmentation and premature sleep curtailment due to disorders and lifestyle - demonstrate that cognitive deficits accumulate to severe levels over time without full awareness by the affected individual.

Functional neuroimaging has revealed that frequent and progressively longer cognitive lapses, which are a hallmark of sleep deprivation, involve distributed changes in brain regions including:

• Frontal and parietal control areas,

• Secondary sensory processing areas,

• And thalamic areas.

There are robust differences among individuals in the degree of their cognitive vulnerability to sleep loss:

• That may involve differences in prefrontal and parietal cortices,

• And that may have a basis in genes regulating sleep homeostasis and circadian rhythms.Thus, cognitive deficits believed to be a function of the severity of clinical sleep disturbance may be a product of genetic alleles associated with differential cognitive vulnerability to sleep loss.

Hello !
I have two years of sleep deprivation as I think I have
'candida' infection.
So far no doctor in Vancouver was able to help me as all
they said " I cant see anything wrong in your mouth , just
gargel with salty water ....."
I wake up at nite with burning tongue dry throat , day time
ok but the skin is peeling of my lower inner mouth and
I did have same large pimples with white tips....
After two years I start to have chest pains ! Now the hart
doctors are able to apply the hart procedures but I did not
accept it till they help me to correct my underlying condition which causing me several waking per night .
I was told that sleeples restles night= sleep depravation does not cause hart problems.
I do not accepting this.
Any input is very welcome.
end.