Chlorine trifluoride is used to make uranium hexafluoride by reacting it with uranium metal. It was looked at as a rocketpropellant. It was also looked at as a poison gas. It is too difficult to make and store, though. Chlorine trifluoride can be used to clean areas where semiconductors are made.

Chlorine trifluoride is extremely toxic and dangerous. It is one of the most dangerous chemicals there is. It can catch many things on fire, including things that are usually non-flammable, such as asbestos, concrete, and glass. The fires are almost impossible to put out. It reacts with most things.