The endgame website has been updated to a bunch of text using coordinates, foreign languages, etc. If there is something hidden there, my cynical side says that solving it will lead "buy my book".ENDGAME IS COMING

In the above linked video ( Endgame Panel at the Com Con 2014), Frey claims that the human genome project, when completed and extrapolated back in time, indicates that the human genetics corresponding to intellect, was artificially altered 12,000 years ago (these are not his exact words, but to that effect). The operative idea here is that it was artificially changed .

CLUE: THE BARBARIAN DOES MAN-SLAUGHTER FORPLOWING: ON HIS YELLOW SAND-PLAINS NOTHING HAS BEEN SEEN BUT BLANCHED SKULLS AND BONES.
What it means: Line from Li Po poem Nefarious War
Source: Nefarious War by Li Po

I think these two clues might actually be one, as according to the caption above the photo on the Wikipedia site you provided a link to, the Orion Constellation is Visible at latitudes between +85° and −75°.

A Million Little Pieces is a book by James Frey, originally sold as a memoir and later marketed as a semi-fictional novel following accusations of literary forgery.[1] It tells the story of a 23-year-old alcoholic and drug abuser and how he copes with rehabilitation in a twelve steps-oriented treatment center. While initially promoted as a memoir, it was later discovered that many of the events described in the book never happened.

The publishers of the book, Doubleday and Anchor Books, initially stood by Frey. But further examination of the evidence eventually caused the publishers to alter their stances. They released a statement noting, "When the Smoking Gun report appeared, our first response, given that we were still learning the facts of the matter, was to support our author. Since then, we have questioned him about the allegations and have sadly come to the realization that a number of facts have been altered and incidents embellished."[18] As a consequence, the publishers decided to include a publisher's note and an author's note from Frey as disclaimers to be included in future publications. According to the source at the company, there had been some disagreement among editors at the publishing house about Mr. Frey’s authenticity, but the early dissenters had been silenced by the book's commercial success, both pre- and post-Oprah.[19]

I think these two clues might actually be one, as according to the caption above the photo on the Wikipedia site you provided a link to, the Orion Constellation is Visible at latitudes between +85° and −75°.