Thierry Ascione (born 17 January 1981) is a retired professional tourmale tennis player from France. He turned pro in 2000 and retired in September 2010, reaching a career-high singles ranking of World No. 81 in February 2004.

He played Roger Federer in the second round of Roland Garros 2007, saving five match points in the third set and holding two set points before eventually losing in straight sets.