The studies presented in this dissertation investigate the enzymatic basis for the species differences in target organ toxicity of the pro-toxin, 4-ipomeanol (IPO). <italic>In vitro</italic> studies that monitored the ...

MUC1 mucins have recently been the target of breast cancer vaccine trials. MUC1 peptide vaccine studies in mice have resulted in rejection of solid tumor and protection from further tumor challenge. These results represent ...

Enveloped viruses such as influenza virus and human parainfluenza virus utilize specialized protein machinery to fuse their membrane with the cellular membrane of target host cells and thus deliver their genome for ...

All viruses undergo a multistep developmental process to assemble a mature virus. An essential step in the assembly of complex double-stranded DNA viruses is packaging the viral genome into a pre-formed procapsid shell. ...