Keywords

Rhinovirus; RNA Virus Infections; RNA Viruses; Virus Uncoating

Research interests

Our research is dedicated to unraveling the molecular mechanisms and structural changes underlying the invasion of host cells by small RNA viruses and the role of host factors for their efficient replication, mainly using human rhinoviruses as a model. Infections by these viruses are normally restricted to the upper respiratory tract leading to the "common cold", but they are also implicated in more severe pathologies such as bronchiolitis and exacerbation of asthma upon spreading to the lung. Due to the ~160 different rhinovirus genotypes vaccination is not practical and no approved anti-rhinoviral drug is yet available. Hence, by molecularly characterizing as yet ill-defined steps in the life-cycle of these prototypic Enteroviruses we also hope to contribute to the discovery of novel drug targets.

Weare presently studying two crucial aspects for propagation of rhinoviruses: Uncoating of the RNA genome and the post-translational modification of certain rhinoviral proteins, and together with colleagues, we develop means to facilitate analysis of non-cultivatable viruses such as the C-type rhinoviruses.