Acutely- respiratory alkalosis because they hyperventilate and blow off their CO2
Later, the patients will tire and get a metabolic acidosis because of increased lactic acid from muslce. CO2 might go up once they get tired. The patient will then have low pH, low pO2, and high CO2 and will need to be intubated

Salmeterol and formeterol because they are long acting B agonists. They are now used for chronic maintenance. They can cause sudden death

Pathophysiology of COPD

-inflammation with neutrophils and macrophages
-Destruction of alveoli due to proteases and you get collage deposition (fibrosis) in the alveoli. This fibrosis causes airway obstruction rather than restriction.
-With proteases from neutrophils you get alveolar wall destruction in emphysema and mucus hypersecretion in chronic bronchitis.

Centrilobular emphysema vs. Panlobular emphysema

Centrilobular is associated with smoking. Damage is in the respiratory bronchiole and it is worse in upper lobes.