Application Information: CD6 antibody [MEM-98]

For FACS: Use at an assay dependent dilution. For IP: Use at an assay dependent dilution. For WB (non-reducing conditions): Use at an assay dependent dilution. Optimal dilutions/concentrations should be determined by the researcher.

Form Supplied

Liquid

Concentration

1
mg/ml
(Please refer to the vial label for the specific concentration)

Purification

Protein A purified

Specifications: CD6 antibody [MEM-98]

Full Name

CD6 molecule

Background

CD6, also known as T12, is a member of the scavenger receptor superfamily found on T and B cell subsets, thymocytes, and acute lymphocytic leukemia cells (ALL). CD6 interacts with its ligand CD166/ALCAM (activated leukocyte cell adhesion molecule) and serves as a coreceptor for T cell activation and stabilizer of the immunological synapse. CD6-ALCAM mediated cell adhesion is also important for T cell proliferation. CD6 may exert some its functions via association with CD5, probably by fine-tuning CD5 signaling. Ligation of CD6 has antiapoptotic role in chronic lymphocytic leukemia B cells.