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Excision Repair Cross Complementing Polypeptide-1 Proteins (ERCC1)

On www.antibodies-online.com are 11 Excision Repair Cross Complementing Polypeptide-1 (ERCC1) Proteins from 6 different suppliers available. Additionally we are shipping ERCC1 Antibodies (281) and ERCC1 Kits (29) and many more products for this protein. A total of 330 ERCC1 products are currently listed.

More Proteins for ERCC1 Interaction Partners

Five of these SNPs acted as cis (show CISH Proteins)-eQTLs, being associated with the transcription of IREB2 (show IREB2 Proteins) (rs2568494, rs16969968, rs11634351, rs6495309), PSMA4 (show PSMA4 Proteins) (rs6495309) and ERCC1 (rs735482), out of 10,821 genes analyzed in lung. For these three genes, we obtained experimental evidence of differential allelic expression in lung tissue, pointing to the existence of in-cis (show CISH Proteins) genomic variants that regulate their transcription.

Gene expression study along with DNA sequence analysis show that different splicing isoforms of ERCC1 affect the expression of its overlapping genes CD3EAP (show CD3EAP Proteins) and PPP1R13L (show PPP1R13L Proteins).

common genetic variations in ERCC1/XPF (show ERCC4 Proteins) genes predispose to neuroblastoma (show ARHGEF16 Proteins) risk, which needs to be further validated by ongoing efforts.

Our results indicated a link between ERCC1 rs3212986 and the onset of late gastrointestinal toxicity ..No association was found regarding the XRCC3 (show XRCC3 Proteins) rs861539 polymorphism and any clinical toxicity event

the present results indicate that the EGFR (show EGFR Proteins) mutation status and TS and ERCC1 expression can be used as the predictors of overall survival after subsequent second-line treatments for adenocarcinoma non-small-cell lung cancer

In conclusion, these findings identified no association between rs11615 and rs2276466 polymorphisms and Colorectal Cancer(CRC (show CALR Proteins)) susceptibility, but the data indicate that ERCC1 rs3212986 and rs2298881 polymorphisms may increase susceptibility to CRC (show CALR Proteins).

we quantified the frequency of aneuploidy of three autosomes in the cerebral cortex and cerebellum of adult and developing brain of Bub1b (show BUB1B Proteins)(H/H) mice, which have a faulty mitotic checkpoint (show BUB3 Proteins), and Ercc1(-/Delta7) mice, defective in nucleotide excision repair and inter-strand crosslink repair. we found that Bub1b (show BUB1B Proteins)(H/H), but not Ercc1(-/Delta7) mice, have a significantly higher frequency of aneuploid nuclei relative to wild-t...

these results establish USP45 as a new regulator of XPF (show ERCC4 Proteins)-ERCC1 crucial for efficient DNA repair

ERCC1 is critical for protecting chondrocytes from catabolic stress and is associated with the pathophysiology of osteoarthritis.

These data support a model in which the interstrand crosslink repair-specific function of XPF-ERCC1 is dependent on recruitment, positioning and substrate recognition.

ERCC1 Protein Profile

Protein Summary

The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease (also known as ERCC4), and the heterodimeric endonuclease catalyzes the 5' incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in this gene result in cerebrooculofacioskeletal syndrome, and polymorphisms that alter expression of this gene may play a role in carcinogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. The last exon of this gene overlaps with the CD3e molecule, epsilon associated protein gene on the opposite strand.