Seth Gabel drew attention for his portrayal of Adrian Moore, the sexually confused adopted son of Ava Moore (portrayed by Famke Janssen) on the FX series Nip/Tuck. The story arc garnered much attention for their incestuous and emotionally abusive relationship.

Born in Hollywood, Florida. He is Jewish. He graduated from University School of Nova Southeastern University in Davie, Florida in 1999, and from New York University's Tisch School of the Arts.

On the big screen Gabel completed production on the Universal Pictures coming-of-age drama, Take Me Home Tonight, starring Topher Grace. He appeared in the 2006 film version of Dan Brown’s novel, The Da Vinci Code, directed by his father-in-law 'Ron Howar'.

Additional television credits include recurring and guest starring roles on United States of Tara, The Closer, Law & Order: Special Victims Unit, CSI: Crime Scene Investigation, Sex and the City and 100 Centre Street, directed by Sidney Lumet.
He also starred in Dirty Sexy Money as Jeremy Darling, the charming, rebellious and exceedingly idiosyncratic son of the privileged and powerful Darling family, and the fraternal twin of socialite Juliet Darling, played by Samaire Armstrong.

During the 2010–11 TV season, Gabel appeared on the FOX series Fringe as Lincoln Lee, a supporting character who is a member of the Fringe Division on the alternate universe. During the third season of the show, he began appearing in a supporting role as the two Lincoln Lees from both universes. Gabel was promoted to the main cast for the fourth season. His character was written off at the end of that season before returning briefly for the series finale.

On January 30, 2013, Gabel was cast on the episode "Vertigo" of the series Arrow as a character based on Count Vertigo, known as the Count. He return 7 episodes later after getting caught on previous storyline.

Gabel met actress 'Bryce Dallas Howard' (daughter of actor/director Ron Howard) at New York University, and they dated for five years before marrying (June 17, 2006), in Greenwich, Connectictt. They have two children: son Theodore Norman "Theo" (b. February 16, 2007) and daughter Beatrice Jean (b. January 19, 2012).