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Pharm into questions Flashcards Preview

Which of the following best defines drug absorbtion?

a. The transfer of the drug from the bloodstream to the tissues. b. The transfer of the drug from the GI track to the bloodstream. c. The transfer of the drug from the tissues back to the bloodstream. d. The transfer of the drug from the site of administration to the bloodstream.

d. The transfer of the drug from the site of administration to the bloodstream.

2

Where is the main site of absorption for internally administered drugs?

a. Stomachb. Terminal ileumc. Upper duodenumd. Lower duodenum

c. Upper duodenum

3

True or False?Plasma protein binding increases the half-life of the drug?

True

4

Which of the following disease states would result in decreased drug distribution?

All of the following are true regarding newborn and pediatric patients except.

d. Decreased total body water

Which of the following types of drug-drug interactions is best defined as the exaggerated effects of two drugs with the same mechanism of action?

a. Summationb. Potentiationc. Synergism d. Antagonism

c. Synergism

18

True or False

Passive diffusion requires energy?

False

19

True or False

Facilitated diffusion requires energy?

False

20

True or False

Active diffusion requires energy?

True

21

Which of the following drug properties would not favor transport via passive diffusion?

a. High lipid solubilityb. Small sizec. Mostly ionized d. Uncharged

c. Mostly ionized

22

Which scenario favors drug absorption the most?

a. A weakly acidic drug introduced into a weakly basic environment b. A weakly acidic drug introduced into a weakly acidic environment c. A weakly basic drug introduced into a weakly acidic environment d. A weakly basic drug introduced into an environment with a pH=drug pKa

b. A weakly acidic drug introduced into a weakly acidic environment

23

What is the definition of clinical pharmacology?

a. The study of the interactions of drugs with living organisms.b. The application of pharmacology principles to patients. c. The study of drugs in different species. d. The science of the preparation of drugs.

b. The application of pharmacology principles to patients.

a. pharmacologyc. comparative pharmacologyd. pharmacy

24

What does ADME stand for in pharmacokinetics?

Absorption, distribution, metabolism, excretion

25

What computer system provides information including withdrawal times of all drugs approved for use in food producing animals?

FARAD (Food animal residue avoidance databank)

26

Which type of oils evaporate readily when exposed to air?

a. Volatile b. Fixedc. Fatty

a. Volatile

27

What is renal clearance usually measured by?

Renal clearance is usually measured by creatinine clearance

28

Which of the following is not a phase 1 metabolic reaction?

a. Oxidationb. Conjugationc. Reductiond. Hydrolysis

b. Conjugation

29

What is the definition of renal insufficiency?

a. Can't metabolize most drugs normallyb. Cant excrete most drugs via the kidney and into the urine normally.c. Can't pump drugs to the site of action, metabolism, or excretion normally.

b. Cant excrete most drugs via the kidney and into the urine normally.

a. Hepatic dysfunction c. Congestive Heart Failure

30

When giving another drug with a different action and 1+1>2 what is this?

a. Summationb. Potentiation c. Synergism d. Antagonism

b. Potentiation

a. Sum of the affects of the drug 1+1=2c. Give another drug with the same action 1+1>2d. Decreases the affect of another drug 1+1<2

31

What are tetracyclines incompatible with?

Calcium

32

At how many half lives is the concentration of a drug at 90%?

a. 2 b. 4c. 3.3 d. 2.2

c. 3.3

33

Which of the following is the treatment of choice for myasthenia gravis?