Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

Details

Applications

Approved:

Western blot

ELISA

Gel shift

Specificity and Use

Immunogen:

MSH6 antibody was raised against human MSH6 produced in baculovirus-infected Sf9 cells.

Specificity:

P1/66. H6 recognizes human DNA mismatch repair protein Msh6 (MSH6), also known as G/T mismatch-binding protein or MutS-alpha 160 kD subunit. MSH6 is a 1360 amino acid ~160 kD nuclear protein containing a single domain and is a member of the MutS family of DNA mismatch binding proteins. MSH6 forms a functional heterodimer with MSH2.

Description: Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS alpha, which binds to DNA mismatches thereby initiating DNA repair. When bound, MutS alpha bends the DNA helix and shields approximately 20 base pairs, and recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA.