Application Information: CBL antibody, C-term

Approx 120kDa band seen in 3T3 lysate. Recommended for use at 1-3µg/ml.

Positive Controls

The peptide used to product this antibody is available for purchase (Catalog Number:GTX89954-PEP).

Form Supplied

Liquid

Concentration

0.5
mg/ml
(Please refer to the vial label for the specific concentration)

Purification

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.

Specifications: CBL antibody, C-term

Full Name

Cas-Br-M (murine) ecotropic retroviral transforming sequence

Product Description

Goat polyclonal antibody to CBL

Background

Participates in signal transduction in hematopoietic cells. Adapter protein that functions as a negative regulator of many signaling pathways that start from receptors at the cell surface. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including PDGFA, EGF and CSF1, and terminates signaling.