Current Research Studies

The studies that are currently ongoing within our department are:

Crash-3

The CRASH-3 trial is a large, international, randomised, placebo controlled trial, to quantify the safety and effect on individuals of the administration of tranexamic acid in patients with Traumatic Brain Injury (TBI). Adults with TBI, who are within eight hours of injury, and meet the criteria of the trial are eligible for inclusion onto the study..

If a simple and widely practicable treatment, such as tranexamic acid, was shown to improve outcomes in patients with traumatic brain injury, then it could be used in high, middle and low income countries, saving many thousands of lives and reducing the burden of disability.

HALT-IT

The HALT-IT trial is a large, international, randomised, placebo controlled trial, to quantify the safety and effect on individuals of the administration of tranexamic acid in patients with significant Gastro-intestinal Bleeding. Adults with GI bleeding who meet the criteria of the trial are eligible for inclusion into the study.

The HALT-IT trial is looking to see if there is a better treatment for gut bleeding. The aim is to determine the effect of early administration of Tranexamic which helps blood clotting and reduce gut bleeding on patients with acute gastrointestinal bleeding.

C4C – Cellulitis study

The aim of this study is to see whether the addition of Clindamycin, a protein inhibiting antibiotic, to the standard antibiotic treatment of limb cellulitis, with Flucloxacillin, results in less tissue damage and a more rapid resolution of both systemic and local features, in a cost-effective manner.

This is an observational, of patients with acute VTE (Venous Thromboembolism). The main focus of this Registry is to capture the real-life management of VTE from the time of diagnosis and to follow up on outcomes in national care settings that are treating VTE patients in the long term. Data will be collected from the patients’ medical records according to specifications Recruited patients will be monitored for a minimum of 36 months from the date of VTE diagnosis onwards. Patients may be asked to have additional optional data collection annually for up to 2 years following the 36 month follow up period.

DiPEP

This study aims to (a) estimate the diagnostic accuracy, effectiveness and cost-effectiveness of strategies (including clinical prediction rules) for selecting pregnant or postpartum women with suspected Pulmonary Embolism for imaging, and (b) determine the feasibility and value of information of further prospective research.

Our research nurse also covers these studies which are active in other areas of the hospital:

PRIME – Developing a tool to stratify the risk of medication harm in the elderly

Paramedic2 – Pre-hospital Assessment of the Role of Adrenaline: Measuring the Effectiveness of Drug administration In Cardiac arrest (Facilitation only)

Below are links to the websites of studies that are mentioned on this page: