Sure, Regis Philbin is irreplaceable. But for the sake of argument, who could potentially fill his shoes when he retires from Live! with Regis and Kelly at the end of this season?

Mark Consuelos and Jeff Probst are possibilities. Both have guest-hosted in Philbin's absence, and Consuelos would have an easy time lobbying for the job – as he's married to current co-host Kelly Ripa.

Some other fun choices: comedian Kathy Griffin, who energizes any talk show she's on; Project Runway's Tim Gunn, who's a friend of the show; and Nick Cannon, who currently hosts his own morning radio program in New York City.