Starting out as a marketing intern at KISS FM,[5] and did some voice-overs.
Starting out her radio career at KISS FM UK presenting the overnight show, she quickly ascended to the Saturday Breakfast and then drivetime show, reaching audiences of 1 million on a weekly basis.

In 2015, Amfo became the host of The Official Chart on BBC Radio 1. In February 2015 it was also announced that she would be taking over from Fearne Cotton as host of Radio 1's mid-morning show – home of the Live Lounge – on 25 May 2015, and therefore be departing from 1Xtra's weekend breakfast show.[12]