11-13 June 2012Rab GTPases and their interacting proteins in health and diseaseUniversity College Cork, Ireland

Meeting description:

Their activity state and functional effects are controlled and or mediated by several interacting proteins, including guanine nucleotide exchange proteins, GTPase Activating proteins, effector and motor proteins. Rab GTPase function is essential for a vast range of normal cellular physiological processes, ranging from Long Term Potentiation (LTP) to cellular uptake of glucose in response to insulin signalling.

Furthermore, they are implicated in a lengthening list of host/pathogen diseases involving viruses, bacteria and parasitic pathogens. Some examples of viral infections include; Influenza-, Dengue-, West Nile-, Foot & mouth-, Coxsackie-, Encephalitis-, Hepatitis C-, Respiratory Syncytial- , Measles-, Hantavirus and Human Immunodeficiency Virus. Examples of bacterial infections with which Rabs have been connected include Chlamydia, Brucella, Salmonella, Listeria, Helicobacter, Mycobacteria. Parasitic conditions with which the Rabs have been connected include Trypanosoma cruzei and brucei.

The meeting will include a keynote presentation on Rabs by Bruno Goud and review presentations on Ras and Rho proteins by Chris Marshall and Alan Hall, respectively.

This meeting will bring together researchers who work on the functional characterization of Rabs and / or their interacting proteins in either normal cellular physiology (health) or in diseases as well as an overview of Ras, Rho and Rab cellular function. ?

Topics

Rab function in the healthy cell

The interplay between Rabs and infectious disease processes

Rabs and inherited diseases

Review of Rho function

Review of Ras function

Reviews by the speakers, based on their presentations at this major international meeting, will be published exclusively in Biochemical Society Transactions (Volume 40, part 6).

Abstract deadline: 9 April 2012.

Abstract submission is now closed. If you would like to submit an abstract please contact the Conference Office.