Vanderbilt Ingram Cancer Center Events

The VICC invites you to attend the NCI Integrative Cancer Biology Program Workshop: "Current Topics in Cancer Systems Biology: Tumor Cell Heterogeneity Workshop" which will be held December 2-3, 2013 in 898J Preston Research Building. This meeting aims at framing some of the current issues associated with the challenges of tumor heterogeneity both from a basic understanding and clinical impact.

In many applications, the underlying scientific theory may impose natural constraints on the parameters of commonly used models. While it is a good practice to maintain the constraints in any inferential procedure related to the parameters, it may turn out to be an extremely difficult proposition due to complexity of the constraints.

In such situations, it helps to reparameterize the problem in terms of parametric functions that

are free of constraints or at least have constraints that are more tractable. We will illustrate the advantages of making parameter transformation in the context of some messy constrained parameter problems.