Jimmy quickly jumped on the subject asking, "There aren't really guys like you but when George Clooney gets married, does it work like everyone else?"

George talked a bit about his guy moments and how Amal Clooney definitely notices when he wears the same shirt a few days in a row. Jimmy then HIGH-lariously reminds George that the marriage is all a SHAM through the ridiculous tabloids featuring the couple.

Ch-ch-check out the video for a sneak at what George can and can't get away with (below)!

In July, father John McCain was diagnosed with stage 4 glioblastoma, an aggressive form of brain cancer, which also claimed Beau's life.

When the 33-year-old began crying, the politician went over and consoled her, adding:

"There is hope... And if anybody can make it, your dad [can]."

Biden is also optimistic about "breakthroughs that are occurring now," regarding potential treatment options and cures.

"There's a lot of things happening. Any of you who have somebody who is diagnosed with gliobastoma, which is about as bad as it gets, there's breakthroughs that are occurring now... And it can happen tomorrow."