In 2011 my 64 year old (at that time) wife was diagnosed with follicular lymphoma. She relapsed within 4 months of R-CHOP (6 cycles) and within 2 months of bendamustine/rituximab/velcade (6 cycles). This is when her oncologist said she had an aggressive form of follicular lymphoma. Next she was in a Phase 2 Ibrutinib clinical trial that lasted 12 months followed by 14 months of Idelalisib/rituximab. After she progressed for the fourth time,in early 2016 she was accepted into an NIH CAR-T trial and was infused on March 2 (her new birthday). She is now in complete remission.

Lovely picture and wonderful news! My NHL has transformed now after 7 years of all kinds of treatment, including stem cell transplant, into aggressive B cell so we are exploring clinical trials at Southampton.

Here is some good news we learned from Dr. Steven Schuster (one of the gurus in CAR-T) during today's Lymphoma Research Foundation "Advances in Immunotherapy in the Treatment of Lymphoma" teleconference Q&A on November 17. Results from his UPENN Abramson Comprehensive Cancer Center follicular lymphoma CAR-T clinical trial showed: