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Arrestins also mediate G protein-independent signaling via GPCRs.

Since GRK and arrestins demonstrate no strict receptor specificity, their functions in the brain may depend on their cellular complement, expression level, and subcellular targeting.

In an appeal, the Muncie man contended there was not sufficient evidence to support two of his molesting convictions.

A Henry Circuit Court 2 jury last September found William G.However, cellular expression and subcellular distribution of GRKs and arrestins in the brain is largely unknown.We show that GRK isoforms GRK2 and GRK5 are similarly expressed in direct and indirect pathway neurons in the rat striatum.This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.G protein-coupled receptor kinases (GRKs) and arrestins mediate desensitization of G protein-coupled receptors (GPCR).Culler, now 60, guilty of four counts of molesting and three counts of vicarious sexual gratification.