Read the Medication Guide that
comes with CellCept before you start taking it and each time you refill your
prescription. There may be new information. This Medication Guide does not take
the place of talking with your doctor about your medical condition or your
treatment.

What is the most important
information I should know about CellCept?

CellCept can cause serious
side effects:

Increased risk of loss of a
pregnancy (miscarriage) and higher risk of birth defects. Females who take CellCept
during pregnancy have a higher risk of miscarriage during the first 3
months (first trimester), and a higher risk that their baby will be born with
birth defects.
If you are a female who can become pregnant

your doctor must talk with you
about acceptable birth control methods (contraceptive counseling) to use while
taking CellCept.

you should have one pregnancy
test immediately before starting CellCept and another pregnancy test 8 to 10
days later. Pregnancy tests should be repeated during routine follow-up visits
with your doctor. Talk to your doctor about the results of all of your
pregnancy tests.

you must use acceptable birth
control during your entire CellCept therapy and for 6 weeks after stopping
CellCept, unless at any time you choose to avoid sexual intercourse
(abstinence) with a man completely.
CellCept decreases blood levels of the hormones in birth control pills that you
take by mouth. Birth control pills may not work as well while you take
CellCept, and you could become pregnant. If you take birth control pills while
using CellCept you must also use another form of birth control. Talk to your
doctor about other birth control methods that you can use while taking
CellCept.
If you plan to become pregnant, talk with your doctor. Your doctor will
decide if other medicines to prevent rejection may be right for you. If you become pregnant while taking CellCept, do not stop taking
CellCept. Call your doctor right away. In certain situations, you and your
doctor may decide that taking CellCept is more important to your health than
the possible risks to your unborn baby.

You and your doctor should report your pregnancy to

Mycophenolate Pregnancy Registry (1-800-617-8191)
The purpose of this registry is to gather information about the health of you
and your baby.

Increased risk of getting serious infections. CellCept
weakens the body's immune system and affects your ability to fight infections.
Serious infections can happen with CellCept and can lead to death. These
serious infections can include:

Viral infections. Certain viruses can live in your
body and cause active infections when your immune system is weak. Viral
infections that can happen with CellCept include:

A brain infection called Progressive Multifocal
Leukoencephalopathy (PML). In some patients, CellCept may cause an
infection of the brain that may cause death. You are at risk for this brain
infection because you have a weakened immune system. You should tell your
doctor right away if you have any of the following symptoms:

Weakness on one side of the body

You do not care about things that you usually care about (apathy)

You are confused or have problems thinking

You can not control your muscles

Fungal infections. Yeasts and other types of
fungal infections can happen with CellCept and can cause serious tissue and
blood infections (see “What are the possible side effects of CellCept?”)

Call your doctor right away if you have any of the
following signs and symptoms of infection:

a brown or black skin lesion with uneven borders, or one
part of the lesion does not look like the other

a change in the size and color of a mole

a new skin lesion or bump

any other changes to your health

See the section “What are the possible side effects of
CellCept?” for information about other serious side effects.

What is CellCept?

CellCept is a prescription medicine to prevent rejection
(antirejection medicine) in people who have received a kidney, heart or liver
transplant. Rejection is when the body's immune system perceives the new organ
as a “foreign” threat and attacks it.

CellCept is used with other medicines called cyclosporine
(Sandimmune®, Gengraf®, Neoral®)
and corticosteroids.

CellCept has been used safely and works in children who
received a kidney transplant as it does in adults. It is not known if CellCept
is safe and works in children who receive a heart or liver transplant.

Who should not take CellCept?

Do not take CellCept if you are allergic to
mycophenolate mofetil or any of the ingredients in CellCept. See the end of
this Medication Guide for a complete list of ingredients in CellCept.

have Lesch-Nyhan or Kelley-Seegmiller syndrome or
another rare inherited deficiency hypoxanthine-guanine
phosphoribosyl-transferase (HGPRT). You should not take CellCept if you
have one of these disorders.

plan to receive any vaccines. People taking CellCept
should not take live vaccines. Some vaccines may not work as well during
treatment with CellCept.

are pregnant or are planning to become pregnant. See “What is the most important information I should know about CellCept?”

are breastfeeding or plan to breastfeed. It is not
known if CellCept passes into breast milk. You and your doctor will decide if
you will take CellCept or breastfeed.

Tell your healthcare provider about all of the
medicines you are taking including prescription and nonprescription medicines,
vitamins and herbal supplements. Some medicines may affect the way CellCept
works, and CellCept may affect how some medicines work. Especially tell your
doctor if you take:

birth control pills (oral contraceptives). See “What
is the most important information I should know about CellCept?”

sevelamer (Renagel®, Renvela™).
These products should be taken 2 hours after taking CellCept

Know the medicines you take. Keep a list of them to show
to your doctor or nurse and pharmacist when you get a new medicine. Do not take
any new medicine without talking with your doctor.

How should I take CellCept?

Take CellCept exactly as prescribed.

Do not stop taking CellCept or change the dose unless
your doctor tells you to.

If you miss a dose of CellCept, or are not sure when you
took your last dose, take the regular amount of CellCept prescribed as soon as
you remember. If it is time for your next dose, skip the missed dose and take
your next dose at your normal scheduled time. Do not take 2 doses at the same
time. Call your doctor if you are not sure what to do.

Take CellCept capsules, tablets and oral suspension on an
empty stomach, either 1 hour before or 2 hours after a meal, unless your
healthcare provider tells you otherwise. With the approval of your healthcare
provider, in stable kidney transplant patients, CellCept can be taken with food
if necessary.

Most people take CellCept by mouth either as blue and
brown capsules or lavender tablets. Some people may get CellCept soon after
their transplant surgery as an infusion into a vein.

Do not crush CellCept tablets. Do not open or crush
CellCept capsules.

If you are not able to swallow CellCept tablets or capsules,
your doctor may prescribe CellCept Oral Suspension. This is a liquid form of
CellCept. Your pharmacist will mix the medicine before giving it to you.

Do not mix CellCept Oral Suspension with any other
medicine.

If you take too much CellCept, call your doctor or the
poison control center right away.

What should I avoid while taking CellCept?

Avoid pregnancy. See “What is the most
important information I should know about CellCept?”

Limit the amount of time you spend in sunlight. Avoid
using tanning beds or sunlamps. People who take CellCept have a higher risk of
getting skin cancer. (See “What is the most important information I should
know about CellCept?”) Wear protective clothing when you are in the sun and
use a sunscreen with a high protection factor (SPF 30 and above). This is
especially important if your skin is very fair or if you have a family history
of skin cancer.

What are the possible side effects of CellCept?

CellCept can cause serious side effects:

See “What is the most important information I should
know about CellCept?”

Low blood cell counts. People taking high doses of
CellCept each day may have a decrease in blood counts, including

white blood cells, especially neutrophils. Neutrophils
fight against bacterial infections. You have a higher chance of getting an
infection when your white blood cell count is low. This is most common from 3
months to 6 months after your transplant.

platelets. Platelets help with blood
clotting.
Your doctor will do blood tests before you start taking CellCept and during
treatment with CellCept to check your blood cell counts.
Tell your doctor right away if you have any signs of infection (see “What is
the most important information I should know about CellCept?”), or any
unexpected bruising or bleeding. Also, tell your doctor if you have unusual
tiredness, lack of energy, dizziness or fainting.

Stomach problems. Stomach and intestinal bleeding
can happen in people who take high doses of CellCept. Bleeding can be severe
and you may have to be hospitalized for treatment.

Common side effects include:

diarrhea. Call your doctor right away if you have
diarrhea. Do not stop taking CellCept without first talking with your doctor.

These are not all of the possible side effects of
CellCept. Tell your doctor about any side effect that bothers you or that does
not go away.

Call your doctor for medical advice about side effects.
You may report side effects to the FDA at 1-800-FDA-1088 or to Genentech at
1-888-835-2555.

How should I store CellCept?

Store CellCept capsules and tablets at room temperature,
between 59oF to 86oF (15oC to 30oC).
Keep the container closed tightly.

Store the prepared CellCept Oral Suspension at room temperature,
between 59oF to 86oF (15oC to 30oC),
for up to 60 days. You can also store CellCept Oral Suspension in the
refrigerator at 36oF to 46oF (2oC to 8oC). Do not freeze CellCept Oral Suspension.

Keep CellCept and all medicines out of the reach of
children

General Information about CellCept

Medicines are sometimes prescribed for purposes other
than those listed in a Medication Guide. Do not use CellCept for a condition
for which it was not prescribed. Do not give CellCept to other people, even if
they have the same symptoms that you have. It may harm them.

This Medication Guide summarizes the most important
information about CellCept. If you would like more information, talk with your
doctor. You can ask your doctor or pharmacist for information about CellCept
that is written for healthcare professionals. For more information, call
1-888-835-2555 or visit www.gene.com/gene/products/information/cellcept.