Orpik a is a defensive D so he's not a #2.
Same thing with Mitchell
Buff and Enstrom are just as good as Markov-Subban offensively, however we all know how much Big Buff cares about D.
Josi is not a #2 D.
Methot: see Orpik
Subban is better than Vlasic
Yandle and OEL are very good but Markov is still better than them which gives us the advantage.

So yes we do have the best D combination possibly tied with St. Louis.

Keith and Seabrook are two #1 d-men as well, and arguably better, unfortunately.

San Jose could run any combination of Boyle, Vlasic and Burns and be an instant contender for top pairing in the league though! Still have it a three horse race with Chicago, then Montreal/San Jose, although I'd have Phoenix and St. Louis as very likely contenders in the near future.