The study was performed in 292 school children aged 11-15 and 1554 adults in Maruyama District in Chiba prefecture to analyze the factors which affect development of Japanese cedar pollinosis (JCPS) in JCP specific serum IgE positive subjects. In 1995 incidence of positive JCP specific serum IgE was 44.9% in school children which increased to 66.0% in young adults aged 20-40, and decreased abruptly in subjects after 50 years old.Incidence of JCPS amoug school children with positive JCP serum antibody was 41.2% which increased to 59.5% in young adults aged 20-40. Development of JCPS was closely related to JCP specific IgE titer. However, development of JCPS was observed in only 62.5% of those who showed highest CAP RAST titer (score 6) in school children under 15. On the contrary JCPS developed in 92.2% of IgE positive adults above 20 years old. Aging is one of the factors which facilitate development of hyperreactive symptoms in serum IgE positive children. In 1995 amount of JCP pollen
… More in Chiba prefecture was 40 times as large as those in 1994 and 1996. In 1996 : 135 out of 292 school children who were registered in 1995 were reevaluated as regards relationship between changes of serum IgE levels and those of hyperreactive JCPS symptoms. All of 36 school children who developed hyperreactive symptoms in 1995 continued to show hyperreactive symptoms and 16 children started to show symptoms in 1996 inspite of marked decrease of JCP counts and stable or decreased IgE level except in 3 children who showed increase of IgE level. Positive family history of JCPS in 3 generations and involvement of perennial nasal allergy facilitated significantly development of JCPS in JCP specific IgE positive subjects. Natural grow-out of JCPS was observed in 8.9% of those with JCPS.Natural grow-out was observed particulary in those who developed JCPS in elder age and those without family history of JCPS.15〜20年間追跡した大学病院アレルギー外来登録奨励における重スギ花粉症の自然寛解は症状消失0%、mc著明改善7.4%、改善34.4%にとどまった。一方、住民検診におけるスギ花粉症の自然寛解率は8.9%であり、自然寛解は特に高年齢発症者およびスギ花粉症の素因の無いものにみられた。大学病院登録奨励と住民検診対象者におけるスギ花粉症の自然寛解率の違いは重傷度の違いによるものと考えられる。 Less