Starting her career as a production assistant at Jacaranda Productions in 1989, Pippa progressed quickly through roles as a script editor for ITV and Channel Four before becoming Development Executive at BBC Films. She was then promoted to Executive Producer, BBC Drama Serials, working on Warriors (1999), Care (2000), The Sleeper (2000), The Way We Live Now (2001) and Love in a Cold Climate (2001).

In 2001 Pippa became Head of Drama Commissioning for the BBC, working with Jane Tranter. BBC commissions included Cutting It (2002), Flesh and Blood (2002), Daniel Deronda (2002), The Lost Prince (2003) and State of Play (2003).

Pippa co-founded Neal Street Productions in 2003 with partners Sam Mendes and Caro Newling. Since forming the company, Pippa has produced several films, including Jarhead (2005), Starter for 10 (2006) and Blood (2012). She has also executive produced the films Things We Lost in the Fire (2007), Revolutionary Road (2008) and Away We Go (2009).

For television, Pippa has produced Stuart A Life Backwards (2007), starring Tom Hardy and Benedict Cumberbatch, as well as the frightening psychological thriller, Penny Dreadful created and written by John Logan, starring Josh Hartnett, Timothy Dalton and Eva Green for Showtime / Sky Atlantic. Pippa also executive produced the critically acclaimed, BAFTA nominated Shakespeare film series, The Hollow Crown (2012) and The Hollow Crown: The War of the Roses (2016) as well as the upcoming Britannia (2018) for Sky Atlantic/Amazon.

Pippa continues to executive produce the hugely successful, BAFTA and NTA winning Call the Midwife, which will return for a seventh series in 2018.

Pippa is Chair of BAFTA, and sits on their board, as well as having previously Chaired the film committee. She is also a Trustee of The Charleston Trust, a Patron of Best Beginnings, and an Ambassador for Women for Women International.