High serum titers of autoantibodies in association with other features suggestive of autoimmune liver disease (> 5 ULN aminotransferases, high globulins, or high total protein to albumin ratio) > work-up for autoimmune liver disease

* NFS is based on 6 variables (age, BMI, hyperglycemia, platelet count, albumin, and AST/ALT ratio) and is calculated using the published formula
http://gihep.com/calculators/hepatology/nafld-fibrosis-score/

Adapted from Chalasani N. Practice Guidance from the AASLD;Hepatology 2018;67:328-357