Esrailian is a full-time faculty member at the David Geffen School of Medicine at UCLA. He is described as having patient care, teaching, and administrative positions.1 His research publications primarily involve irritable bowel syndrome. He has often been quoted in media reports about patient education topics.234 He was appointed by Governor Arnold Schwarzenegger to the Medical Board of California and served from 2010-2011.5

Besides being involved in philanthropic projects for UCLA itself, Esrailian is on the Board of Directors of a college access organization called the Fulfillment Fund.6 He is listed as having involvement with organizing multiple charity events, such as "Stars," for the organization to raise money for educational support for disadvantaged students in Los Angeles.78 In 2009, he started the "Dream" benefit concert series together with friends in the entertainment industry. He joined the Board of Directors of the Hammer Museum in 2012.9 Esrailian is also on the Board of Trustees of the X Prize Foundation which is a non-profit organization that designs and manages public competitions intended to encourage technological development that could benefit mankind.10 Esrailian is on the Motion Picture & Television Fund (MPTF) Foundation Board of Governors [1] and the central board of the Armenian General Benevolent Union (AGBU).[2]

Esrailian was one of Farrah Fawcett's physicians and was the one she contacted when she believed her private medical records had been leaked to the press.11 He appeared in "Farrah's Story," the 2009 documentary about her.12

Esrailian gave a eulogy at the funeral for Georgia Frontiere and has a statement posted on the team website.13