Lee Hall Depot became a very busy railroad station after the establishment nearby of Fort Eustis (originally named Camp Abraham Eustis) in 1918, with freight and heavy troop movements. the busy activity resumed during World War II. It was expanded to accommodate this role. East of Lee Hall, a rail spur leads to the base, where the Fort Eustis Military Railroad operated.

Earlier, the east-west road which became U.S. 60 was State Route 9. SR 9 was renumbered as State Route 39 in 1923, and became U.S. 60 in the mid-1920s when it was routed through Grove. A large ceremony hosted by Warwick County treasurer and civic leader Simon Curtis was held at the Lee Hall Depot in 1924 to celebrate the completion of first hard-surfaced roadway (concrete) between Newport News and Williamsburg.

Two-laned U.S. 60 continues to form the main thoroughfare through the largely residential and neighborhood business section of Grove and Lee Hall, paralleling four-laned State Route 143 and Interstate 64. The village portion of Lee Hall is connected to I-64 via State Route 238 (Yorktown Road).

Although Warwick County became a city in 1952 and then was consolidated with Newport News in 1958, in the half century since, the Lee Hall area has retained a rural atmosphere, partially due to the proximity of the expansive Newport News Park and Newport News Reservoir along the former Warwick River and nearby Skiffe's Creek.

The 26th Balloon Company of the US Army Air Corps had a training school at Lee Hall at least during the summer of 1920 training soldiers for deployment to central and South America service.[1]

In the 21st century, Lee Hall Depot (no longer is use) is the only surviving C&O structure of its type on the Lower Peninsula. It is the only survivor among five stations which were located in Warwick County, the others formerly located at Oriana, Oyster Point, Morrison, and Newport News.There are plans to relocate the historic 2-story depot slightly to the north of the busy CSX Transportation railroad tracks, as well as redevelop the adjacent historic area as Lee Hall Village. Across the street from the Depot, the Boxwood Inn, a bed and breakfast establishment in an 1896 house, is open and available for overnight visitors and some meals. The city's tourism agency operates several other attractions at Lee Hall Mansion and Endview Plantation, as well as nearby civil war historical sites.

As of late 2009, the Lee Hall Depot has been moved across the street, and when it is restored it will once again have reserved areas for train boarding by passengers, accommodating potential future rail growth. This seems likely, given that since 2008, Amtrak ridership has increased significantly, and there are currently plans to add two additional train depot stations for Amtrak within Newport News, one in downtown and one near the Newport News Williamsburg International Airport.

For direct service to the Williamsburg Amtrak and Greyhound/Carolina Trailways station, ride the WAT Grey Line to the Williamsburg Transportation Center. For service to the same in Newport News, ride HRT Route 116 to the Newport News Greyhound station or ride the 116 and transfer to the 106 or 107 to get to the Newport News Amtrak station.