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"I have tried hard--but life is difficult, and I am a very useless person. I can hardly be said to have an independent existence. I was just a screw or a cog in the great machine I called life, and when I dropped out of it I found I was of no use anywhere else."

I'm interested in your combination, as I'm taking the same drugs but without the Raltegravir. Do you know what sort of level of benefit there is adding Raltegravir into the mix, and did you and the doctor discuss this combination without that particular drug?

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''Poor is the man whose pleasures depend on the permission of another.''

I'm interested in your combination, as I'm taking the same drugs but without the Raltegravir. Do you know what sort of level of benefit there is adding Raltegravir into the mix, and did you and the doctor discuss this combination without that particular drug?

Oh honey I don't really know.

I was meant to be on this combo without the Truvada but Alain or possibly RAB suggested I needed to have it added. So I kvetched at my doctor to have it added.

And to shut me up, she agreed.

Frankly my eyes glaze over when Frau Eva discusses the drugs, so I'm not sure about the fucking details.

But to answer your question, yes I think raltegravir was always part of it.

Interesting. Although I'm not sure I'd want to add a fourth pill to my regime and the one I'm on at the moment means I can take them all at once in the morning and then forget about it. Still, I might ask my doc about the benefits of Raltegravir with this particular combination when I have my next consultation.

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''Poor is the man whose pleasures depend on the permission of another.''

Interesting. Although I'm not sure I'd want to add a fourth pill to my regime and the one I'm on at the moment means I can take them all at once in the morning and then forget about it. Still, I might ask my doc about the benefits of Raltegravir with this particular combination when I have my next consultation.

Honey, you can add whatever you want to your regimen. Just stop schmutzing my thread up with it. This is a Matty the Damned production and he performs alone.

3-drug HAART regimens are standard for initial treatment patients, or those that change regimens due to side effects. A 4-drug regimen is often used for those with more advanced HIV, resistance issues and I guess *cough* adherence issues like the OP.

3-drug HAART regimens are standard for initial treatment patients, or those that change regimens due to side effects. A 4-drug regimen is often used for those with more advanced HIV, resistance issues and I guess *cough* adherence issues like the OP.

Matty,happy for you bud! I to am on the norvir/Prezista combo and I miss 20% of the dose the past month.. My t-4s are over 1,000 and unD viral load. My Dr. even prescribed one norvir per day (Instead of 2 per day) and reduced the Prezista. He is sure that my cholesteral will improve by this new dose! Your on to something good.

You offer much sagacious advice on these forums. You can joke around about it all you want, but Iím surprised that with all your knowledge on matters HIV you still think adherence isnít important. Iím sure a brilliant mind like yours can come up with some way to remind yourself to take that morning dose. How about when you take the evening dose, put out the dose for the next morning in a place where youíll be sure to see it in the morning.

"...health will finally be seen not as a blessing to be wished for, but as a human right to be fought for." Kofi Annan

Nymphomaniac: a woman as obsessed with sex as an average man. Mignon McLaughlin

HIV is certainly character-building. It's made me see all of the shallow things we cling to, like ego and vanity. Of course, I'd rather have a few more T-cells and a little less character. Randy Shilts

Been on my new regimen (Raltegravir/Norvir/Truvada/Prezista) for a month or so.

Viral Load down from 96,000 to 496.

CD4 up from 12% to 14% (it's like in the 200s)

Oh yeah.

I keep forgetting to take the morning dose, but with numbers like these who gives a shit?

MtD

My Dear Damned,

This post just made my month. I am so happy for you and you better make sure that you are totally compliant with your meds. No excuses, you know better and if you won't do it for you, then please do it for me.

I keep forgetting to take the morning dose, but with numbers like these who gives a shit?

MtD

It's the main dose I miss as well. I've resorted to taking it at different hours to keep from missing it all together, but for some reason still manage to miss at least one dose a week on average. Shits hard man...fuck.

It's the main dose I miss as well. I've resorted to taking it at different hours to keep from missing it all together, but for some reason still manage to miss at least one dose a week on average. Shits hard man...fuck.

Come on guys, get with the program. Get yourself a pill box, that breaks down by day and/or time and then you can fill it and forget it. I have one that splits each day into four sections, but I only take pills twice daily, so that gives me two full weeks of pills in one case. If I think I missed a pill, a quick check will tell me. I have had drug regimens that baffled the human mind and without pill cases, I would not still be here.

I can't buy this missed dose talk, as if it were unimportant. Get a grip, get organized and get compliant.

Come on guys, get with the program. Get yourself a pill box, that breaks down by day and/or time and then you can fill it and forget it. I have one that splits each day into four sections, but I only take pills twice daily, so that gives me two full weeks of pills in one case. If I think I missed a pill, a quick check will tell me. I have had drug regimens that baffled the human mind and without pill cases, I would not still be here.

I can't buy this missed dose talk, as if it were unimportant. Get a grip, get organized and get compliant.

The pharmokinetics of all drugs is good enough. Specifically, raltegravir has a long half-life, and is being tested as once-a-day right now, with good first results. Darunavir is approved once a day for treatment-naive people, so the PK works, and truthfully if you are on the 600mg dose the difference between 1 and 2 times a day in terms of effectiveness is unlikely to mean anything in practice, plus it is considerably better than missing a dose from a 2 x daily schedule.

There are many plebeians in this here joint then. Just ask any of the Atripla chirrens. And here I always thought that I was royalty.

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"I have tried hard--but life is difficult, and I am a very useless person. I can hardly be said to have an independent existence. I was just a screw or a cog in the great machine I called life, and when I dropped out of it I found I was of no use anywhere else."

"I have tried hard--but life is difficult, and I am a very useless person. I can hardly be said to have an independent existence. I was just a screw or a cog in the great machine I called life, and when I dropped out of it I found I was of no use anywhere else."

Amazing. You must be relieved. As Newt noted the current study of once-a-day Raltegravir caused me to ask a couple ofdocs about it (as that's what I'll restart in another month). They affirm and one said while they wouldn't "agree to it" they concede patients having been using it off-label at once a day with great results.

With your clever graphics abilities, couldn't you doll up your pillbox to make it an attractive place to visit twice a day?

The pharmokinetics of all drugs is good enough. Specifically, raltegravir has a long half-life, and is being tested as once-a-day right now, with good first results. Darunavir is approved once a day for treatment-naive people, so the PK works, and truthfully if you are on the 600mg dose the difference between 1 and 2 times a day in terms of effectiveness is unlikely to mean anything in practice, plus it is considerably better than missing a dose from a 2 x daily schedule.