Halogenated furanones

Halogenated compounds elatol extracted from the marine red algae Laurencia majuscule elatol has shown activity against the human pathogenic bacteria species Staphylococcus epidermis, Klebsiella pneumonia, and Salmonella, whereas iso-obtusol shown action on K. pneumonia and Salmonella species (Vairappan, 2003). Halogenated furanone isolated from the marine algae Delisea pulchra has shown broad spectrum antibiotic action against the bacterial bio film formation, quorum sensing (QS), and swarming, but the molecular mechanism is completely not elucidated. Studies on action of halogenated furanones on biosynthetic pathway AI-2, which is found in most of the Gram-positive and Gramnegative bacteria and will covalently modify the LuxS enzyme (S-ribo-sylhomocysteine lyase, EC 4.4.1.21) which produces autoinducers-2 (AI-2), thereby showing action on bacterial QS; therefore, these furanones can be used for clearing the bacterial films on the ponds and lakes (Zang et al., 2009).

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