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"This Skin Notation Profile presents (1) a brief summary of technical data associated with skin contact with acrylamide and (2) the rationale behind the hazard-specific skin notation (SK) assignment for acrylamide. The SK assignment is based on the scientific rationale and logic outlined in the Current Intelligence Bulletin (CIB) 61: A Strategy for Assigning New NIOSH Skin Notations [NIOSH 2009]. The summarized information and health hazard assessment are limited to an evaluation of the potential health effects of dermal exposure to acrylamide. A literature search was conducted through July 2010 to identify information on acrylamide, including but not limited to data relating to its toxicokinetics, acute toxicity, repeated-dose systemic toxicity, carcinogenicity, biological system/function-specific effects (including reproductive and developmental effects and immunotoxicity), irritation, and sensitization. Information was considered from studies of humans, animals, or appropriate modeling systems that are relevant to assessing the effects of dermal exposure to acrylamide. Acrylamide is potentially capable of causing numerous adverse health effects following skin contact. A critical review of available data has resulted in the following SK assignment for acrylamide: SK: SYS-DIR (IRR)-SEN. Table 1 provides an overview of the critical effects and data used to develop the SK assignment for acrylamide." - NIOSHTIC-2

NIOSH skin notations are hazard warnings used worldwide to alert workers and employers to the health risks of skin exposures to chemicals in the workplace. This Current Intelligence Bulletin (CIB) provides the rationale for assigning new NIOSH skin n...

"The available data in both humans and animals indicate that disulfoton is absorbed through skin, is systemically available, acutely toxic and potentially fatal following acute dermal exposure [Gaines 1969; Bayer AG 1978], and can cause cholinesteras...

National Institute for Occupational Safety and Health, Education and Information Division.

Published:

April 2011

Series:

DHHS publication ; no. (NIOSH) 2011-141

Description:

"This Skin Notation Profile presents (1) a brief summary of technical data associated with skin contact with DNB and (2) the rationale behind the hazard-specific skin notation (SK) assignment for DNB. The SK assignment is based on the scientific rati...