Sen çaresizlik nedir bilir misin

English translation: Do you know what it's like to be helpless

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Have you ever fallen into despair? have you ever felt being at the end of your tether?

Explanation:Have you ever fallen into despair? or
have you ever felt being at the end of your tether?
I think best is to ask in perfect tense in "have you ever" form, otherwise it sounsd a little strage (To my non-native ears) :)