Agent Smith, voice dripping with disdain, eyes covered with his trademark shades, is the "muscle" of the Matrix and Neo's (Keanu Reeves) indefatigable foe. Intent on erasing Neo and obliterating the Zion warriors, Smith can replicate himself into the hundreds and thousands -- a virtual army with superhuman martial arts skills to boot.

A vestige of Earth's late 20th-century eugenics wars, superman Khan has a super ego to match. Banished to a deserted planet in an episode of the 'Star Trek' TV series, Khan seeks revenge on the man who imprisoned him, his nemesis: Capt. James T. Kirk.

Crime kingpin of Lumberton, N.C., Booth never met a form of depravity that he didn't like. His kinky sexual affinities include huffing gas, erotic asphyxiation, sadomasochism ... and those are just the ones we can print. Throw in mutilation, kidnapping and murder and you've got one well-rounded (if not well-grounded) sociopath.

Her name (an amalgam of cruel and devil) sums up this crazed old bag who steals puppies with an eye to weaving their fur into ... gulp! ... coats. A monstrous fashionista, Cruella looms large in the pantheon of animated villains. As the song goes: "Cruella De Vil, Cruella De Vil, if she doesn't scare you, no evil thing will."

Over the course of a single day, rogue narcotics agent Harris "evaluates" a rookie (Ethan Hawke) and subjects him to a litany of depredations and humiliations that end in extortion and murder. Washington won a Best Actor Oscar in the role of a streetwise cop on the make who can't distinguish between good and evil anymore.

Dunaway chews more scenery than Secretariat ("No. More. Wire. Hangers!" ring a bell?) and keeps daughter Christina in such a state of abject terror in this camp classic that it's hard to believe the angelic child ever had the strength, years later, to write a dishy, tell-all memoir. Talk about payback.

Ah-nuld's original Terminator gets all the glory, but it's Patrick's T-1000, a prototype model made of shape-shifting liquid metal, that truly terrorizes. This homicidal robot is the ultimate hit man who won't stop until his mission (to kill resistance leader John Connor) is completed or he ends up on the scrap heap -- whichever comes first.

Ex-Nazi concentration camp dentist Szell (in a role inspired by the infamous Dr. Mengele) uses a variety of drills, probes and picks to get to the, um, root of the matter when torturing Dustin Hoffman on whether "it's safe" to retrieve his horde of diamonds at a Manhattan bank. Pass the Novocaine, please.