PDH 1.The first step in the decarboxylation of pyruvate is a. Reduction of NAD+ to generate NADH + H+ b. Nucleophilic attack by the carbanion of TPP to pyruvate c. Reduction of lipoic acid by FADH2d. Nucleophilic addition of CoA-SH to pyruvate e. Acetyl group transfer from TPP to lipoic acid 2.Which of the Following is not a PDH cofactor? 3.What are the end products of reactions catalyzed by the PDH? 4.Beriberi is a disease that results from TPP deficiency. Patients with this disorder have increased serum

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Unformatted text preview: levels of: a. glucose b. pyruvate c. citrate d. lactate e. B and D 5. How many different subunits make up the PDH complex? a. 1 b. 2 c. 3 d. 4 6. Where is Pryuvate Dehydrogenase Complex located in the cell? e. Nucleus f. Membrane of the mitochondria g. Matrix of the mitochondria h. Cytoplasm 7. The 1 st step is unidirectional because: i. It is the first step j. CO2 is released k. It’s an oxidation reduction reaction l. Pyruvate has attached to CoASH...
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