Medical Xpress news tagged with:molecular alterationshttp://medicalxpress.com/
en-usMedical Xpress internet news portal provides the latest news on science including: Physics, Nanotechnology, Life Sciences, Space Science, Earth Science, Environment, Health and Medicine.Results from three ground-breaking cancer studies show early benefit to patientsThe "revolution in the understanding of cancer at the molecular level" has led to dramatic responses in cancer patients to new therapies that are targeted precisely at their particular type of tumours, according to an expert.http://medicalxpress.com/news/2016-11-results-ground-breaking-cancer-early-benefit.html
CancerWed, 30 Nov 2016 20:12:44 ESTnews399759154Discovery of likely subtypes of rare childhood brain tumor signals diagnostic advanceAn international research team has identified four likely new subtypes of a rare brain tumor using molecular techniques that lay the foundation for more accurate diagnosis and tailored therapies for the hard-to-treat cancer. Scientists at St. Jude Children's Research Hospital and the German Cancer Research Center led the study, results of which appear today in the scientific journal Cell.http://medicalxpress.com/news/2016-02-discovery-subtypes-rare-childhood-brain.html
CancerThu, 25 Feb 2016 12:00:04 ESTnews375620336Poor survival among colorectal cancer patients tied to biomarker CSN6A protein called CSN6 has been found to be correlated with poor survival among patients with colorectal cancer, according to a study at The University of Texas MD Anderson Cancer Center.http://medicalxpress.com/news/2015-08-poor-survival-colorectal-cancer-patients.html
CancerMon, 10 Aug 2015 12:00:03 ESTnews358420606Molecular profiling of Ketamine's rapid antidepressant effectOne third of the patients with major depressive disorder suffer from treatment resistance and do not respond to commonly used antidepressants. Ketamine, a drug that works through a different mechanism, improves depressive symptoms within hours and is particularly effective in treatment-resistant patients. Scientists at the Max Planck Institute of Psychiatry in Munich have for the first time identified metabolite alterations, affected pathways and biomarker candidates for the Ketamine treatment response in mice. An improved understanding of the molecular events causing the rapid antidepressant effect of Ketamine will allow the development of alternative drugs with a similar mode of action but fewer side effects.http://medicalxpress.com/news/2014-11-molecular-profiling-ketamine-rapid-antidepressant.html
Psychology & PsychiatryWed, 12 Nov 2014 05:58:01 ESTnews334994274EORTC presents European solution for effective cancer drug developmentDrug developers are facing the perfect storm. They are confronted with major patent expiries, increased payer scrutiny, changing priorities, shifting business models, increased risk averseness, increased clinical trial costs, not to mention issues concerning R&D productivity. There needs to be a better way to identify new candidate drugs. There needs to be a new drug development pathway that is compatible with research aimed at understanding the biology of a cancer and simultaneously able to support the design and conduct of subsequent confirmatory trials, but building and maintaining such a drug development pathway is beyond the ability of individual organizations or companies. It has been argued that new forms of partnership as well as an integrated model of cancer research are needed. Now, in a paper published in Nature Reviews Clinical Oncology, the EORTC describes how collaborative molecular screening platforms could help serve these needs.http://medicalxpress.com/news/2014-07-eortc-european-solution-effective-cancer.html
CancerTue, 01 Jul 2014 09:35:54 ESTnews323426143Using molecular techniques, researchers improved diagnosis and treatment of cancerThe ABC Medical Center, located in Mexico City, implemented various molecular diagnostic methods that can detect the genetic alterations in several types of cancer, so they can select a personalized therapy for each patient and direct it against the mutated genes that cause disease.http://medicalxpress.com/news/2014-05-molecular-techniques-diagnosis-treatment-cancer.html
CancerTue, 13 May 2014 07:08:18 ESTnews319183681Lifestyle influences metabolism via DNA methylationAn unhealthy lifestyle leaves traces in the DNA. These may have specific effects on metabolism, causing organ damage or disease. Scientists of Helmholtz Zentrum München have now identified 28 DNA alterations associated with metabolic traits. This world-first epigenome-wide association study (EWAS) of modified genes and metabolites has been now published in the journal Human Molecular Genetics.http://medicalxpress.com/news/2013-09-lifestyle-metabolism-dna-methylation.html
GeneticsFri, 20 Sep 2013 07:32:14 ESTnews298881114Clinical trials for cancer, one patient at a timeColumbia University Medical Center (CUMC) researchers are developing a new approach to cancer clinical trials, in which therapies are designed and tested one patient at a time. The patient's tumor is "reverse engineered" to determine its unique genetic characteristics and to identify existing U.S. Food and Drug Administration (FDA)-approved drugs that may target them.http://medicalxpress.com/news/2013-07-clinical-trials-cancer-patient.html
CancerMon, 15 Jul 2013 13:39:56 ESTnews293114383Study confirms everolimus can overcome trastuzumab resistance in HER-2 positive early breast cancerA study that aimed to understand how the cancer drug everolimus helps overcome the resistance breast cancers can develop to trastuzumab has left researchers contemplating a puzzle.http://medicalxpress.com/news/2013-05-everolimus-trastuzumab-resistance-her-positive.html
CancerThu, 02 May 2013 10:35:22 ESTnews286709710Colon cancer exhibits a corresponding epigenetic pattern in mice and humansTumourigenesis is driven by genetic alterations and by changes in the epigenome, for instance by the addition of methyl groups to cytosine bases in the DNA. A deeper understanding of the interaction between the genetic and epigenetic mechanisms is critical for the selection of tumour biomarkers and for the future development of therapies. Human tumour specimens and cell lines however contain a plethora of genetic and epigenetic changes, which complicate data analysis. In contrast, certain mouse tumour models contain only a single genetic mutation and allow the analysis of nascent tumours. Scientists of the Max Planck Institute for Molecular Genetics in Berlin have now discovered a recurring pattern of more than 13,000 epigenetic alterations in young tumours of the mouse. This genome-wide pattern was found to be partly conserved in human colon carcinoma, and may therefor facilitate the identification of novel clinical colon cancer biomarkers for early detection.http://medicalxpress.com/news/2013-02-colon-cancer-epigenetic-pattern-mice.html
GeneticsThu, 07 Feb 2013 17:00:03 ESTnews279472308Genetics may explain severe flu in Chinese peopleA genetic variant commonly found in Chinese people may help explain why some got seriously ill with swine flu, a discovery scientists say could help pinpoint why flu viruses hit some populations particularly hard and change how they are treated.http://medicalxpress.com/news/2013-01-genetics-severe-flu-chinese-people.html
Diseases, Conditions, SyndromesTue, 29 Jan 2013 12:01:07 ESTnews278683239Preventing prostate cancer through androgen deprivation may have harmful effectsMice deficient in PTEN in the prostate developed stable precancers. Androgen deprivation promoted progression to invasive prostate cancer. Patients with PTEN-deficient prostate precancers may not benefit from androgen deprivation chemoprevention therapy.http://medicalxpress.com/news/2012-12-prostate-cancer-androgen-deprivation-effects.html
CancerThu, 20 Dec 2012 10:39:48 ESTnews275222382Molecular 'portraits' of tumours match patients with trials in everyday clinical practiceResearchers in France are taking advantage of the progress in genetic and molecular profiling to analyse the make-up of individual cancer patients' tumours and, using this information, assign them to particular treatments and phase I clinical trials—an approach that could become part of everyday clinical practice.http://medicalxpress.com/news/2012-11-molecular-portraits-tumours-patients-trials.html
CancerThu, 08 Nov 2012 18:00:04 ESTnews271613695Molecular subtypes and genetic alterations may determine response to lung cancer therapyCancer therapies targeting specific molecular subtypes of the disease allow physicians to tailor treatment to a patient's individual molecular profile. But scientists are finding that in many types of cancer the molecular subtypes are more varied than previously thought and contain further genetic alterations that can affect a patient's response to therapy.http://medicalxpress.com/news/2012-05-molecular-subtypes-genetic-response-lung.html
CancerFri, 11 May 2012 15:12:55 ESTnews255967873Identifying acute myeloid leukemia gene mutations may indicate risk, best treatmentAn international group of researchers, including those from Moffitt Cancer Center in Tampa, Fla., have published a paper in the March 14 issue of the New England Journal of Medicine reviewing the results of a study that analyzed mutations in 18 genes of 398 patients who had acute myeloid leukemia (AML). They found that several mutated genes predicted improved outcomes when patients with certain gene mutations were given high-dose induction chemotherapy. Their findings suggest that mutational profiling could potentially be used for both risk stratification and also in helping health care providers make therapeutic decisions for some AML patients.http://medicalxpress.com/news/2012-03-acute-myeloid-leukemia-gene-mutations.html
CancerFri, 23 Mar 2012 11:24:52 ESTnews251720682Researchers find important 'target' playing role in tobacco-related lung cancersResearchers at Moffitt Cancer Center in Tampa, Fla., have discovered that the immune response regulator IKBKE (serine/threonine kinase) plays two roles in tobacco-related non-small cell lung cancers. Tobacco carcinogens induce IKBKE and, in turn, IKBKE induces chemotherapy resistance.http://medicalxpress.com/news/2012-02-important-role-tobacco-related-lung-cancers.html
CancerThu, 09 Feb 2012 12:55:37 ESTnews248014519Defects in the packaging of DNA in malignant brain tumorsGlioblastomas grow extremely aggressively into healthy brain tissue and, moreover, are highly resistant to radiation therapy and chemotherapy. Therefore, they are regarded as the most malignant type of brain tumor. Currently available treatment methods are frequently not very effective against this type of cancer. Glioblastoma can affect people of all ages, but is less common in children than in adults.http://medicalxpress.com/news/2012-01-defects-packaging-dna-malignant-brain.html
CancerMon, 30 Jan 2012 12:35:35 ESTnews247149325Research gives new hope to those with rare vascular cancerA specific genetic alteration has been discovered as a defining feature of epithelioid hemangioendothelioma (EHE), a rare but devastating vascular cancer. These findings have also been used to develop a new diagnostic test for this blood vessel disease.http://medicalxpress.com/news/2011-08-rare-vascular-cancer.html
CancerWed, 31 Aug 2011 14:29:27 ESTnews234019737Lung tumors in never-smokers show greater genomic instability than those in smokersLung adenocarcinomas in people who have never smoked show greater genome instability than those in smokers, supporting the theory that lung cancer in never smokers arises through different pathways, according to research presented at the 14th World Conference on Lung Cancer in Amsterdam, hosted by the International Association for the Study of Lung Cancer (IASLC).http://medicalxpress.com/news/2011-07-lung-tumors-never-smokers-greater-genomic.html
CancerTue, 05 Jul 2011 04:50:46 ESTnews229060229ALK rearrangement found in nearly 10 percent of patients in Lung Cancer Mutation ConsortiumALK rearrangement has been found in 9.6% of lung cancer patients tested in the Lung Cancer Mutation Consortium, and MET amplification in another 4.1%, reflecting how many patients might benefit from targeted therapies such as crizotinib, according to research presented at the 14th World Conference on Lung Cancer in Amsterdam, hosted by the International Association for the Study of Lung Cancer (IASLC).http://medicalxpress.com/news/2011-07-alk-rearrangement-percent-patients-lung.html
CancerTue, 05 Jul 2011 04:50:12 ESTnews229060183