(AP) -- Jake Peavy is doing all he can to end the longest winless stretch of his otherwise solid 13-year career.

Perhaps facing a former team he's fared well against will help.

Winless since late April, Peavy looks to snap a career-high five-start skid and help the San Francisco Giants avoid a sixth straight defeat Wednesday against the visiting Chicago White Sox.

Peavy (0-3, 4.82 ERA) is 0-12 with a 5.25 ERA in 18 starts since beating Toronto on April 25 with Boston for his only victory in 23 outings this season.

He received an average 2.76 runs of support while going 1-9 with a 4.72 ERA in 20 starts for the Red Sox, and six total while on the mound during his three with San Francisco (62-57). The right-hander gave up three runs and nine hits in 5 2-3 innings of a 3-1 loss at Milwaukee on Thursday.

"I've got to do more," Peavy told MLB's official website. "This entails making better pitches in crucial situations, because I can't give any more than I've given."

Peavy has looked strong while allowing three runs and eight hits in 13 innings to go 1-0 in two starts against the White Sox since they traded him to Boston at the 2013 trade deadline. He gave up a homer to Adam Dunn, two other hits, struck out eight and walked four in six innings of a 2-1 loss at Chicago on April 15.

After rallying with two runs in the ninth to force extra innings Tuesday, the Giants fell 3-2 in 10 to the White Sox.

A loser in 13 of 18 and six of seven at home, San Fransisco has totaled nine runs during the five-game slide. The Giants, who dropped a season-high six in a row twice this season, are six games back of the first-place Los Angeles Dodgers in the NL West.

They've also lost five straight interleague games, and are 1-9 against the AL since winning their first six this season. The Giants have lost six consecutive contests against the White Sox (57-63), including all four at home in the series.

After being stymied for eight innings by Chicago ace Chris Sale on Tuesday, San Francisco could be in for another difficult task when Jose Quintana (6-8, 3.04 ERA) faces the club for the first time.

The left-hander is 3-1 with a 1.82 ERA in his last 10 starts, but that loss came Friday when he allowed all four runs - two earned - in a fifth inning he never finished during a 4-1 defeat at Seattle.

Dunn, who hit a two-run homer in the first inning Tuesday, is 3 for 7 in his last two games after going 0 for 19 in his previous five.

Half of his six hits in 32 at-bats against Peavy have left the park.

Michael Morse has faced Quintana the most of any Giant, going 1 for 6 with two strikeouts. Morse, however, is batting .353 in his last five games.

Brandon Crawford drove in the tying run with a single Tuesday for his third hit in 28 at-bats.