QB

As mentioned in the opener, there are four QBs that will be heavily targeted in Week 1 due to matchups. That won't scare me away but their price tag might. These four guys will allow you to spend money at the WR position to take advantage of all four QBs in the Saints/Raiders Packers/Jaguars games.

RB

Adrian Peterson vs the Tennessee Titans is a very safe play, but just about every owner will be taking advantage of that. Teams ran all over the 49ers last year, and scored 20 rushing TDs, but Todd Gurley's price tag is just too high.

TE

Even without Tom Brady, Rob Gronkowski will have high ownership. Jimmy Garoppolo
has completed 5 passes to Martellus Bennett this preseason and A.J. Derby leads all TEs with 10 receptions - clearly the Pats offense runs through the TE position. Against that Cardinals defense, I am avoiding all Patriots players.

I would expect Coby Fleener to be a popular play as well in his debut with Drew Brees.