Severity of histological damage was graded according to the stren

Severity of histological damage was graded according to the strength of inflammatory Selleckchem PD0325901 cell infiltration and liver cellular necrosis. TNF-α and INF-γ levels in supernatant fluid released from

lymphocytes of the spleens were also measured. Results: Results: The EAIHs induced by peak II protein plus CFA and S100 plus CFA had significantly higher histological grades (2.8 and 2.6 on average) than those induced by peak I proteins plus CFA and peak III proteins plus CFA or by CFA alone and saline alone (2.2, 1.6, 1.0 and 0.2 respectively) (p

pancreas (SLA/LP), liver kidney microsomal type 1(LKM-1), liver cytosol type 1(LC-1) and mitochondrial type II (AMA-M2) were tested by Western blot. Results: Among 103 patients with elevated liver enzymes, LKM-1 was positive in 2 patients and SLA/LP in 1 patient and AMA-M2 in 3 patients. The positive rates of ANA, AMA, SMA in chronic hepatitis B group were 12.9%, 1.1%, 2.3% respectively; that in patients with elevated liver enzymes group were 34.9%, 8.7%, 12.6% respectively; that selleck chemicals llc in control group were 5.0%, 0, 0 respectively. The positive rates of ANA, AMA, SMA in chronic hepatitis B group and in patients with elevated liver enzymes group were significantly increased as compared with those of control group (p