Previous HGNC Symbols for CYP46A1 Gene

Previous GeneCards Identifiers for CYP46A1 Gene

Summaries for CYP46A1 Gene

Entrez Gene Summary for CYP46A1 Gene

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is expressed in the brain, where it converts cholesterol to 24S-hydroxycholesterol. While cholesterol cannot pass the blood-brain barrier, 24S-hydroxycholesterol can be secreted in the brain into the circulation to be returned to the liver for catabolism. [provided by RefSeq, Jul 2008]

UniProtKB/Swiss-Prot for CYP46A1 Gene

Involved in the turnover of cholesterol. It converts cholesterol into 24S-hydroxycholesterol and, to a lesser extent, 25-hydroxycholesterol. Has also activity with xenobiotic compounds, such as clotrimazole.

Involved in the turnover of cholesterol. It converts cholesterol into 24S-hydroxycholesterol and, to a lesser extent, 25-hydroxycholesterol. Has also activity with xenobiotic compounds, such as clotrimazole.

SOURCE GeneReport for Unigene cluster for CYP46A1 Gene:

mRNA Expression by UniProt/SwissProt for CYP46A1 Gene:

Tissue specificity:Expressed in brain. The mRNA was broadly distributed with higher levels in gray matter zones and lower levels in regions rich in white matter. Not detected in fetal sample but its expression increases linearly with age.

No data available for
UniProtKB/Swiss-Prot and
Genatlas
for CYP46A1 Gene

Publications for CYP46A1 Gene

cDNA cloning of cholesterol 24-hydroxylase, a mediator of cholesterol homeostasis in the brain.(PMID: 10377398)Lund EG … Russell DW(Proceedings of the National Academy of Sciences of the United States of America 1999)2342258