3148mástiks – properly, a disease that (literally) carried a torturous level of pain (the root is, "a scourge/plague"). "The plague (mastigos) or scourge, was a whip used in flagellations, as on Paul, to find out his guilt (Ac 22:24, cf. Heb 11:26). It is an old word that was used for afflictions regarded as a scourge from God" (WP, 1 299).

When 3148 (mástiks) refers to a disease (Mk 3:10, 5:29,34; Lk 7:21), it emphasizes the oppressive pain (suffering) of this acute disorder – acting like a scourge ("plague") which is highly painful and debilitating.

Acts 22:24N-DFPGRK:παρεμβολήν εἴπας μάστιξιν ἀνετάζεσθαι αὐτὸνNAS: that he should be examined by scourging soKJV: should be examined by scourging; thatINT: barracks having directed by flogging to be examined him