c. ~2800 "70 years after the formation of the Protoculture Stellar Republic, 497,130 years ago": a Protoculture Survey Ship landed on Earth and genetically influenced the existing native life to spur the emergence of "mankind". Records of Earth are soon lost due to ongoing civil war.

Around the same time, similar genetic development projects result in several other human-like sentient races. These subcultures are commonly known as Children of Protoculture. In addition to humans, they include Zolans, Ragnans, Windermereans and Voldorians[1].

c. 475,000 years ago - the Protoculture became nearly extinct as a result of worsening civil war.

c. ? at some point Protoculture or one of its faction made contact with Vajra (alien species from Macross Frontier)

about 10,000 years ago: technologically-advanced remnants of Protoculture rediscovered Earth, left some artifacts in Pacific Islands (events of Macross Zero)