In order to provide an improved in vitro model with which to investigate human diseases, such as cancer that may be promoted by toxicant exposure, we have characterized a newly developed cell line derived from the renal proximal tubule epithelial...

Estrogen and glucocorticoid receptors (ER and GR) are both members of the same subfamily of steroid nuclear receptors, and can both signal classically as ligand-activated transcription factors. However, many responses to estrogen and...

In the work presented here we have used a function-based approach to isolate 12 novel cell-penetrating peptides from a 10,000+ member peptide library of rational design. Our unique high-throughput screen differentiates non-membranolytic from...

MicroRNAs (miRNAs) are small non-coding 18-22 long RNAs, which act as key mediators in many cellular processes involved in tumorigenesis including proliferation, differentiation, invasion, and apoptosis. miRNAs repress gene expression by inhibiting...

During the critical period of CNS development, dendritic architecture is shaped, in part, by activity-dependent stabilization and elimination of branches. This restructuring is partly dependent on the subunit composition of glutamate receptors in a...

During the development of the nervous system, a complex system of
chemical and mechanical cues guide nerve cell projections toward appropriate
targets by eliciting attractive or repulsive responses from navigating
structures called growth cones....

Differentiation in Friend erythroleukemia cells (FELC) is induced by dimethylsulfoide (DMSO). FELC can be also induced to differentiate along the erythrocytic pathway by aphidicolin (APC), a specific inhibitor of DNA polymerase $\alpha$. The tumor...

This dissertation can be divided into two parts project goals. The first one is the synthesis of rhenium (Re) complexes which are potential reverse saturable absorber (RSA) materials. The second one is the polymerization of ruthenium (Ru)...

The use of ethanol as an additive to gasoline fuel is becoming a common phenomenon. It helps solve the energy crisis and environmental issues that fossil fuel has brought about. However, when dissolved in motor oil, ethanol would dilute motor oil...

MicroRNAs (miRNAs) are a group of small, noncoding RNAs that modulate the translation of genes into proteins by binding to specific target sites in messenger RNAs. This study investigated the biological function and molecular mechanism of...