Biological sciences

The Zw5 protein, a component of the scs chromatin domain boundary, is able to block enhancer-promoter interaction

Article Abstract:

Identification and characterization of SBP, scs binding protein, one part of the scs nucleoprotein complex, is reported, as is the information that SBP is encoded by the zeste-white 5 gene. The Zw5 protein, one part of the scs chromatin domain boundary, has been shown to be able to block enhancer-promoter interaction. The scs and scs' elements had been proposed as functioning as chromatin domain boundaries for the 87A7 Drosophila melanogaster heat shock locus.

Research has been conducted on origin recognition complex which marks chromosomal positions as replication origins. The authors suggest that the complex's interaction with its target site in Saccharomyces cerevisiae modulates its activity within a heterochromatin domain in vivo.

Protein:protein interactions and the pairing of boundary elements in vivo

Article Abstract:

Research has been conducted on Drosophila boundary proteins. Results demonstrate that these proteins interact with each other both in vivo and in vitro, and that these interactions may facilitate boundary element pairing.