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Mucosal immunity

B Cell Design develops a new mucosal immunotherapy approach for generating a large number of drug and vaccine candidates in infectious field and oncology. The innovation is based on a genetically modified mouse model (HAMIGA) producing chimeric human IgA. IgA is a class of antibodies particularly involved in the immunity of mucosal area (lung, gut, genital tract, ...) and associated glands (breast, prostate). Because of this characteristic, IgA is a well-adapted tool to develop innovative treatment for both infectious diseases and mucosal cancer.