The Cuban marine flora and fauna is characterized by its richness in species that represents an extraordinary natural source of unexplored biomolecular diversity. Many of those biomolecules could represent important tools for industrial applications. For this reason, in our Centre the main aim was focused on the isolation, purification and characterization of bioactive compounds present in marine invertebrates with particular emphasis on sponges, seaweeds and marine plants. Microorganisms represent also an important source of biologically active compounds that were included in our studies. In our Institution, research is performed by a multidisciplinary team. The purpose of this work is to review the most important results of the Centre of Marine Bioproducts in the last few years.