I've recently started playing The Binding of Isaac, and I've noticed that some walls can be bombed to reveal a secret room containing coins, or items. The problem is, I can't tell which ones can be ...

I cannot go past level 3/4 because when I enter in rooms full of monsters the game start lagging a lot and controls do not respond at all or with a huge delay.
My configuration is not actually bad: ...

These doors are grey and usually (always?) open into a "weapon" room, i.e. there is a weapon on the minimap for them. I've gotten in two, but it was very non-obvious what I did to open the doors. For ...

After playing some more the Binding of Isaac I've come across strange messages that are triggered by certain events.
For instance, when I defeated one of the bosses, I suddenly got a pop-up message ...

I've noticed that the poo piles left by Larry Jr (or the later stage unnamed twin worm-like things) can be broken for hearts and soul hearts. Is there a limit to how many drops can be made from Larry ...

In the Binding of Isaac, if a stat has all of its bars filled when I look at the pause screen, does an item that raises that stat for a single room cause an effective increase of that stat past the ...

What are all the keys used in The Binding of Isaac?
I'm going to configure my joystick using one of the tools suggested at How to setup the joypad for Binding of Isaac? (Xpadder, JoyToKey, QJoyPad, ...

I recently bought the Binding of Isaac + soundtrack.
...so how do I actually access the soundtrack?
The soundtrack shows up when I view downloadable content via steam, and it shows that I own it in ...

On a certain level of this basement, I found 2 locked doors but only 1 key. I think I have cleared out everything I can from this level but I still only found one key. Are there always as many keys ...

Hosts are the skulls that occasionally raise themselves up to shoot at you. When they raise themselves, that is the only time you can damage them. I can't seem to find any sort of pattern and end up ...

With the Wrath of the Lamb expansion, The Binding of Isaac now has two different kinds of secret rooms, and together they seem to have somewhat complex placement rules.
If I can only search for these ...

I just started playing the Binding of Isaac and one of the pick-ups I came across was a black/blue-ish heart (much like the red ones that fill up your HP). Initially, I thought it was a sort of "heart ...

While playing the Binding of Isaac, I should have died when fighting Monstro II, but instead I got a message on a blue screen saying (I think): "Today is a bad day to have a castle". It gave me half a ...

The Blood Donation Machine allows you to trade half a heart pre-Womb or a whole heart in or after the Womb for some amount of money. Additionally, there is a chance that the machine will explode and ...

I'm evaluating whether or not I should get this rather cheap DLC and I've boiled it down to the two following questions. I'll draw the conclusions myself.
Does the DLC change the game forever? Is it ...

In the new type of room similar to the challenge room, you are hurt whenever you enter or leave (there are teeth in the doorway). In this room, there was a red chest, and the room was styled similarly ...

In Binding of Issac Wraith of the Lamb I picked up a Range Down Pill that I already identified. Some time during the play-through it changed to a Range Up Upgrade. I am not sure when it happened or ...

I have beaten Isaac the Cathedral level once, and when I returned to the title screen, there was a rectangle with what appeared to be a piece of a puzzle in it. I infer that I can complete the puzzle ...

I have no idea what a lot of these items do. I have seen a small description appear when I first pick up the item, but it goes away after a few seconds. When I pause the game, I can see the list of ...