Gervais and Johnny Depp went head-to-head for the second year running (Picture: NBC/Getty)

After asking the A-lister whether he was ‘on recreational drugs’, he poked more fun at the 2010 movie’s box office results when he asked Depp: ‘Have you seen The Tourist yet?’

Later on in the evening, The Office star introduced Madonna to the stage and told the audience in a sarcastic tone that she was ‘like a virgin.’

However, the veteran pop star – who was awarded Best Original Song for Masterpiece from W.E. – quickly retaliated and quipped back, ‘If I’m still like a virgin, Ricky, then why don’t you come over here and do something about it? I haven’t kissed a girl in a few years … on TV.’

Madonna hit back at Gervais when she took to the stage (Picture: NBC/Getty)

Gervais also took down Colin Firth by trying to tarnish his wholesome image.

After giving the King’s Speech actor a tirade of compliments, Gervais joked, ‘What you don’t know about him is he’s very racist … I’ve seen him punch a little blind kitten. Please welcome the evil Colin Firth.’

And in his closing speech Gervais mocked his entire celebrity audience in one fell swoop.

He said: ‘Hope you enjoyed the champagne and the goodie bag and the gold sprinkled on the dessert. Hope it took your mind off the recession.’