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Product Specific Information

MA1-27412 detects Estrogen Receptor beta from human and New World primate samples.

MA1-27412 has been successfully used in immunohistochemistry (Frozen and paraffin) procedures. Positive control of ovary suggested.

The MA1-27412 immunogen is a synthetic peptide corresponding to the C-terminal domain of human oestrogen receptor beta 1 isoform.

Store at 4°C or -20°C if preferred. Avoid freeze/thaw cycles.

Background/Target Information

The human ER-beta is a newly discovered estrogen receptor initially cloned and characterized from testis. The size and structure of ER-beta is very similar to ER-alpha with the ligand and DNA binding domains being highly conserved, while the amino terminus which serves as their transactivation domain has diverged significantly. Similar in function to ER-alpha ER-beta binds to estrogen with a high affinity and regulates estrogen specific gene activation through direct interaction with estrogen response elements (ERE's).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.