Zirm was born in Vienna, he studied medicine at the University of Vienna,[2] and ophthalmology at the Eye Clinic there.[3] After graduation, Zirm became an eye doctor at the Second Eye Clinic in Vienna, then accepted a position at a hospital in Olomouc, Moravia, in 1892. There he became chief of the new ophthalmology clinic that he helped establish.[4]

Memorial plaque at Eye Clinic in hospital in Olomouc shows the text in the Czech language: Dr. Eduard Konrad Zirm has performed the first transplant of the cornea in the world on 7th December 1905 in this building. [This plaque] was made in 2005.

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Human corneal transplantation (keratoplasty) had been attempted with little or no success throughout the 1800s using both animal donor cornea and human graft tissue. The donor tissue whether animal or human could either be transplanted as a full-thickness disc of cornea or partial-thickness (layers or lamellae) cornea was attached to the host eye. By the late 1880s lamellar grafts were considered to have a better chance of success than full-thickness corneal grafting which invariably failed a few days after the operation.[1]

In 1905, Zirm encountered a patient Alois Glogar, a 45-year old day farm labourer from a small town in the Czech Republic whose corneas in both eyes had tuned white-bray and opaque a year earlier while working with slakinglime. Around the same time he examined Glogar, an 11-year-old boy named Karl Brauer was brought to Zirm's clinic with penetrating eye-injury to both eyes and iron metal foreign bodies irretrievably lodged in his eyes. When attempts to save Brauer's eyes were unsuccessful, Zirm, with the boy's father's permission[1]enucleated them and saved the corneas for transplantation into Glogar's. Although complications affected one eye, the other remained clear allowing Glogar to return to work.[2]

The operation and the consequent healing processes were difficult at that time because without a microscope and microsurgical instruments it was impossible to suture the donor cornea to the host tissue. Therefore, Zirm successfully sutured the conjunctival tissue over the graft-host junction.[1] During the twentieth century, parallel advances in microscopy, microsurgical instrumentation anaesthesia and asepsis have led to the increasing success of keratoplasty.[5] Zirm 's method remains the basis for repairing corneal damage.

At the jubilee lecture relative to corneal transplant, Prof. Böck, the long-time head of the Second Ophthalmology Department at the University in Vienna said:

"The name of Dr. Eduard Zirm will always be connected with the great accomplishment of this medical technique. With pride the Ophthalmology Department of the University of Vienna includes him as one of its own".

In 2006, in a review of Zirm's landmark paper on his first successful full thickness corneal transplant, three English ophthalmologists concluded in the British Journal of Ophthalmology:

""Zirm showed undoubted skill and insight, but serendipity, as with many advances in medicine and science, must also have played some part in this remarkable achievement that paved the way for the successful treatment of many thousands of patients around the world with corneal disease"."[1]