GREMLIN Results:
Residue pairs sorted by strength in covariance:Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

i

j

Raw Score

Scaled Score

4_F

27_E

0.31264

2.404

40_C

87_C

0.27758

2.135

37_E

88_K

0.25005

1.923

37_E

86_E

0.24235

1.864

8_N

11_L

0.23846

1.834

12_I

20_V

0.22225

1.709

62_R

69_E

0.21994

1.691

57_F

60_I

0.20381

1.567

12_I

40_C

0.19804

1.523

41_R

60_I

0.19062

1.466

48_N

57_F

0.18929

1.456

33_G

88_K

0.18364

1.412

2_F

6_Y

0.17928

1.379

1_W

5_V

0.17766

1.366

28_L

32_M

0.17438

1.341

41_R

45_R

0.17028

1.309

39_I

43_Y

0.16959

1.304

19_A

23_K

0.16599

1.276

4_F

33_G

0.16567

1.274

33_G

37_E

0.16386

1.260

12_I

89_W

0.16291

1.253

5_V

24_I

0.16243

1.249

40_C

43_Y

0.16212

1.247

61_G

75_V

0.16161

1.243

64_W

69_E

0.16117

1.239

29_N

33_G

0.16056

1.235

55_F

74_A

0.15997

1.230

29_N

89_W

0.14871

1.144

3_R

31_Y

0.14749

1.134

2_F

66_K

0.14661

1.127

36_F

65_D

0.14615

1.124

37_E

69_E

0.14607

1.123

26_P

72_I

0.14544

1.118

74_A

83_L

0.14504

1.115

76_D

79_G

0.14439

1.110

83_L

89_W

0.1429

1.099

17_G

20_V

0.14056

1.081

69_E

88_K

0.14041

1.080

63_W

74_A

0.13782

1.060

33_G

86_E

0.13774

1.059

13_E

59_E

0.13736

1.056

32_M

35_A

0.13581

1.044

9_R

14_R

0.13543

1.041

72_I

85_G

0.13501

1.038

10_S

21_Y

0.13453

1.035

45_R

60_I

0.13172

1.013

63_W

68_E

0.13142

1.011

1_W

55_F

0.12948

0.996

41_R

72_I

0.12927

0.994

3_R

27_E

0.12788

0.983

71_D

88_K

0.12665

0.974

8_N

24_I

0.12627

0.971

12_I

17_G

0.12549

0.965

10_S

14_R

0.12408

0.954

6_Y

19_A

0.12381

0.952

71_D

86_E

0.12277

0.944

47_L

78_D

0.12259

0.943

61_G

70_I

0.12244

0.942

69_E

86_E

0.12191

0.937

2_F

90_T

0.12072

0.928

48_N

83_L

0.12039

0.926

65_D

85_G

0.11996

0.923

54_P

87_C

0.11951

0.919

37_E

64_W

0.11938

0.918

31_Y

35_A

0.11934

0.918

57_F

69_E

0.11901

0.915

25_K

46_R

0.11741

0.903

73_V

84_F

0.11735

0.902

16_R

20_V

0.11699

0.900

1_W

70_I

0.11669

0.897

45_R

84_F

0.116

0.892

77_E

84_F

0.11581

0.891

3_R

8_N

0.11503

0.885

16_R

19_A

0.11424

0.879

9_R

19_A

0.11273

0.867

16_R

21_Y

0.11179

0.860

41_R

85_G

0.11173

0.859

29_N

60_I

0.11157

0.858

72_I

87_C

0.11054

0.850

41_R

49_R

0.10955

0.842

4_F

31_Y

0.10825

0.832

20_V

25_K

0.10825

0.832

1_W

22_E

0.10791

0.830

36_F

40_C

0.10657

0.820

33_G

71_D

0.10475

0.806

36_F

91_N

0.10465

0.805

24_I

32_M

0.10431

0.802

14_R

45_R

0.10416

0.801

32_M

89_W

0.10406

0.800

40_C

89_W

0.10396

0.799

45_R

72_I

0.10336

0.795

63_W

67_N

0.1026

0.789

37_E

71_D

0.10258

0.789

21_Y

65_D

0.10226

0.786

3_R

30_Q

0.1022

0.786

87_C

91_N

0.10175

0.782

38_E

42_E

0.10091

0.776

27_E

31_Y

0.10034

0.772

18_E

47_L

0.10005

0.769

36_F

89_W

0.09995

0.769

38_E

46_R

0.09966

0.766

6_Y

27_E

0.09929

0.764

42_E

54_P

0.0982

0.755

38_E

62_R

0.09817

0.755

10_S

24_I

0.09742

0.749

4_F

42_E

0.09707

0.746

9_R

16_R

0.09598

0.738

58_S

84_F

0.09566

0.736

58_S

76_D

0.09556

0.735

36_F

43_Y

0.09544

0.734

2_F

76_D

0.09496

0.730

62_R

84_F

0.09446

0.726

28_L

31_Y

0.09427

0.725

78_D

90_T

0.09391

0.722

35_A

47_L

0.09384

0.722

48_N

54_P

0.09319

0.717

68_E

89_W

0.0928

0.714

1_W

4_F

0.09217

0.709

14_R

23_K

0.09214

0.709

16_R

38_E

0.09206

0.708

6_Y

9_R

0.09162

0.705

67_N

91_N

0.09162

0.705

75_V

91_N

0.09154

0.704

29_N

74_A

0.09142

0.703

74_A

85_G

0.09114

0.701

13_E

86_E

0.09092

0.699

72_I

82_I

0.0909

0.699

57_F

84_F

0.09071

0.698

65_D

87_C

0.0907

0.697

Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.

HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits: Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)