That jolt in morning coffee

Whether athletes can enhance their performance with caffeine may depend on their genes.

According to a new study of the genetics of caffeine metabolism, athletes with a particular variant of one gene show notable improvements in their endurance performance after swallowing caffeine

But those with a different variant of that gene may perform worse if they first have caffeine, raising questions about who should be using the drug to bump up performance and about the broader interplay of nutrition, genetics and exercise.

For many of us, caffeine, usually in the form of coffee, is as necessary to the morning as sunrise.

But different people respond differently to the effects of caffeine. SOme become jittery and later have difficulty sleeping. Others can drink the same amount of coffee and report increased alertness but no jitters or sleep disruptions.

The same range of reactions occurs in athletes. In multiple past studies, most people will work out longer, faster or more strenuously after they swallow a moderate dose of caffeine, but a few perform no better or even worse.

A few years ago, these disparities drew the attention of Ahmed El-So-hemy, a professor of nutritional science at the University of Toronto in Canada, who studies how people’s genes influence their bodies’ reactions to foods and diets. He is the founder of Nutrigenomix, a company that provides genetic testing related to nutrition

By then, other geneticists had established that a specific form of one gene affects how people metabolize caffeine. That gene, prosaically called CYP1A2, controls the expression of an enzyme that affects the breakdown and clearance of caffeine from the body.

One variation of the CYP1A2 gene prompts the body to rapidly metabolize caffeine. People who have 2 copies of this variant, one from each parent, are known as fast caffeine metabolizers; the drug gives them a quick jolt and is gone.

By most estimates, about half of us are fast metabolizers.

Another variant of the gene slows caffeine metabolism.

People with one copy of this version and one of the faster-metabolizing type are considered to be moderate metabolizers, whereas people with two copies of the slow-metabolizing variant are, of course, slow caffeine merabolizers.

In 2006, Dr. El-Sohemy and his colleagues published a study in Jama showing that slow metabolizers had a heightened risk of heart attacks if they frequently drank coffee, compared to people who were genetically classified as fast caffeine metabolizers. The Scientists theorized that the drug, which can constrict blood vessels, hung around and produced longer-lasting – and in this case undesirable – cardiac effects among the slow metabolizers.

But Few large experiments had focused on how people’s CYP1A2 genetic profile might influence their athletic performance after swallowing caffeine.

So for the new study, which was published this month in Medicine & Science in Sports & Exercise, Dr. ElSohemy, together with his graduate student Nanci Guest and other Colleagues , decided to ply about 100 willing, young, male athletes with various doses of the drug. (The Study was funded in part by Nutrigenomix, as well as Coca-Cola and the Canadian Institutes of Health Research; the funders did not influence the results, Dr.ElSohemy says)

It’s as true of athletes as it is of the rest of us: Different people react differently to coffee

Athletes’s responses to caffeine are linked to genes, which raises questions on its use

THe Scientists swabbed the men’s cheeks, analyzed their CYP1A2 genes and, based on which variants each man carried, categorized them as fast, moderate or slow caffeine metabolizers.

Then they had the athletes complete three separate sessions of pedaling a stationary bicycle for 10 kilometers as quickly as possible. Before one ride, the men received a low dose of caffeine (2 milligrams for every kilogram of their body weight, or about the amount found in one large cup of coffee). Before another, they swallowed twice as much caffeine, and before a third, a placebo.

Their subsequent time trial results showed that, on aggregate, the men performed better with caffeine, especially after the higher amount.

But there were substantial differences by gene type.

The Fast metabolizers rode nearly 7% faster after they had downed the large dose of caffeine compared to the placebo

The moderate metabolizers, by contrast, performed almost exactly the same whether they had received caffeine or a placebo.

IT was the slow metabolizers, however, who showed the greatest impact, although in a negative direction.

They completed the 10-kilometer ride about 14% more slowly after the higher does of caffeine than after the placebo.

Just how caffeine differentially boosted of blunted the men’s athletic performance remains unclear.

But Dr. El-Sohemy suspects that, as in the heart-attack Study, caffeine lingered in the slow metabolizers narrowing their blood vessels and reducing the flow of blood and oxygen to tiring muscles.

In fast metabolizers, the drug likely provided a quick rush of energy and then was cleared from their bodies “before it could do the bad stuff”, he says

This study involved only healthy young men and bicycling. It cannot tell us whether caffeine likewise gooses or inhibits performance for other people other sports

And it cannot answer the broader question of whether we need a genetic test before deciding if we should mainline coffee in advance of our next workout

Physical performance involves, after all, so many factors, including motivation, sleep, stress, overall nutrition, and the working of a vast number of genes, many still unidentified.

SO if you find that coffee seems to impede your performance, you could use a genetic test to characterize your CYP1A2 gene and confirm that you are a slow metabolizer.