Researchers investigated the role of monoamine oxidase A (MAOA) in the development of prostate adenocarcinoma by creating a prostate-specific Pten/MAOA knockout (KO) mouse model, in which MAOA-floxP mouse was crossed with the conditional Pten KO prostate cancer (PCa) mouse that develops invasive PCa. [Oncogene]
Abstract

Twenty-two compounds were found to be either potent activators or inhibitors of intracellular GFP signal in the CD63-GFP-expressing C4-2B cells. The lead compounds tipifarnib, neticonazole, climbazole, ketoconazole, and triademenol were validated as potent inhibitors and sitafloxacin, forskolin, SB218795, fenoterol, nitrefazole and pentetrazol as activators of exosome biogenesis and/or secretion in prostate cancer cells. [Sci Rep]
Full Article

Researchers found that VCaP, CWR22Rv1, LNCaP, and LAPC4 models demonstrated induction of HSD3B1 upon androgen stimulation for approximately 72 hours followed by attenuation around 120 hours. HSD3B1 expression was reduced 72 hours post-castration in the VCaP xenograft mouse model, suggesting AR regulation of HSD3B1 also occurs in vivo. [Endocrinology]
Abstract

The authors discuss the current methods for prostate cancer stem cell (PCSC) enrichment and analysis, the hallmarks of PCSC metabolism and the role of PCSCs in tumor progression. [Stem Cells]
Abstract | Full Article

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PROCEPT BioRobotics, has announced early data from the global Phase III WATER II (Waterjet Ablation Therapy for Endoscopic Resection of prostate tissue) Study showing the achievement of primary safety and efficacy endpoints for Aquablation in the treatment of benign prostatic hyperplasia. [Press release from PROCEPT BioRobotics, Inc. discussing research presented at the American Urological Association (AUA) Annual Meeting, San Francisco]
Press Release

Bayer and the University of Texas MD Anderson Cancer Center have signed a five-year collaboration agreement to accelerate the development of novel targeted treatments based on patient or tumor characteristics for which current therapies have not shown satisfactory clinical efficacy. [Bayer AG]
Press Release

For the third time in ten years, UT Health San Antonio has garnered highly competitive National Institutes of Health (NIH) grants to speed the translation of research discovery into improved patient care. UT Health San Antonio will receive $24 million over the next five years under the Clinical and Translational Science Award Program. [UT Health San Antonio]
Press Release

The Department of Energy’s Oak Ridge National Laboratory (ORNL) is now producing actinium-227 (Ac-227) to meet projected demand for a highly effective cancer drug through a ten-year contract between the U.S. DOE Isotope Program and Bayer. Xofigo is used to treat prostate cancer that no longer responds to hormonal or surgical treatment that lowers testosterone. Ra-223, the active ingredient in Xofigo, is currently derived from global supplies of existing Ac-227. [Oak Ridge National Laboratory]
Press Release

One of the world’s richest science awards, given only in alternate years, will go to three discoverers of the CRISPR-Cas9 genome-editing tool, the Norwegian Academy of Science and Letters announced. Emmanuelle Charpentier of the Max Planck Institute for Infection Biology, Jennifer Doudna of the University of California, Berkeley, and Virginijus Šikšnys of Vilnius University will each receive a gold medal and share the $1 million that comes with the Kavli Prize in nanoscience. [STAT News]
Editorial

On 7 June, the European Commission will lay out detailed plans for one of the biggest single research programs on the planet. Called Horizon Europe, the program could be worth €97.6 billion between 2021 and 2027, up from about €77 billion for the current seven-year program, Horizon 2020. Its influence, however, will go beyond size. [ScienceInsider]
Editorial

Scientists at one of Germany’s leading neuroscience institutes say that their employer, the Max Planck Society, is failing in its responsibility to defend the institute’s scientists against efforts by animal-rights activists to disrupt research. [Nature News]
Editorial

Nearly two years after Britons voted to leave the European Union, Brexit’s impact on European science is finally coming into focus. Prime Minister Theresa May announced that the United Kingdom wants to take part in the next EU research-funding program, set to be worth almost €100 billion (US$116 billion). [Nature News]
Editorial

Swedish researchers can now publish their articles in Frontiers’ Open Access journals through a simplified process that covers publishing fees, thanks to a national agreement announced between Frontiers and the National Library of Sweden, on behalf of the organizations participating in the Bibsam Consortium. [EurekAlert]
Editorial

China has issued the first national guidelines to enforce academic integrity in scientific research and vowed to punish academics and institutes for misconduct such as plagiarism and fabrication of data. [South China Morning Post Publishers Ltd.]
Editorial