Instruct patients about prevention
measures to minimize risk of bleeding and to report signs and symptoms of
bleeding [see PATIENT INFORMATION].

DRUG DESCRIPTION

COUMADIN (warfarin sodium) is an anticoagulant that acts by
inhibiting vitamin K-dependent coagulation factors. Chemically, it is
3-(α-acetonylbenzyl)-4- hydroxycoumarin and is a racemic mixture of the R-
and S-enantiomers. Crystalline warfarin sodium is an isopropanol clathrate. Its
empirical formula is C19H15NaO4, and its
structural formula is represented by the following:

Crystalline warfarin sodium occurs as a white, odorless,
crystalline powder that is discolored by light. It is very soluble in water,
freely soluble in alcohol, and very slightly soluble in chloroform and ether.

What are the precautions when taking warfarin sodium (Coumadin)?

Before taking warfarin, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.