Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

TP, MK, JFF, MO, PGK, and SK designed the study. TP, SB, and AD analysed patient data; AS analysed the BIA data and constructed the models; AW and LB conducted the analysis of heavy water; and LW analysed the bromide data. TP and SK wrote the first draft of the paper; all authors commented extensively on subsequent drafts.