Chemical
in coffee may help prevent obesity-related disease - Science Daily, 11/14/14
- "chlorogenic acid, or CGA, significantly reduced insulin resistance and
accumulation of fat in the livers of mice who were fed a high-fat diet ... which
is found in great abundance in coffee, but also in other fruits and vegetables
like apples, pears, tomatoes and blueberries ... CGA was not only effective in
preventing weight gain, but it also helped maintain normal blood sugar levels
and healthy liver composition ... CGA is a powerful antioxidant that reduces
inflammation" - See chlorogenic acid at Amazon.com.

Could Coffee Bean Extract Help Control Blood Sugar? - WebMD, 4/9/13 -
"Vinson's study analyzed 30 men and women of normal
weight who did not have diabetes. They took supplements containing between
100 milligrams (mg) and 400 mg of the green coffee extract in a capsule with
water, followed by glucose tolerance tests at several points afterward ...
All doses of the extract appeared to lower participants' blood sugar levels,
Vinson said, but a dose of 400 mg was associated with a 24 percent drop 30
minutes after taking the extract and a 31 percent drop 120 minutes later ...
Vinson said he believes the sugar-lowering effects of green coffee extract
are due to its concentration of chlorogenic acids -- antioxidants found in
apples, cherries, plums and other fruits and vegetables. High temperatures
used to roast coffee beans typically break down chlorogenic acids, he said,
so coffee beverages contain less of them than extracts found in supplements"
- [Science
Daily]

Why Coffee May Reduce Diabetes Risk - WebMD, 1/13/12 -
"The Chinese researchers looked at three major
active compounds in coffee and their effect on stopping the toxic
accumulation of the protein: ... Caffeine ... Caffeic acid or CA ...
Chlorogenic acid or CGA ... All three had an effect. However, caffeic acid
was best"

Java Reduces
Type 2 Diabetes Risk - WebMD, 11/7/02 -
"Caffeine is known to decrease the body's response
to insulin. However, other ingredients found in
coffee --
magnesium and chlorogenic acid -- may have
beneficial effects ... researchers followed more than 17,000 Dutch adults.
After several years of follow-up, those who drank seven or more cups a day
were half as likely to develop type 2 diabetes compared with those who drank
less than two cups a day ... The long-term effects of drinking too much
caffeine are not known and other health issues could develop

Chlorogenic Acid Extends
the Lifespan of Caenorhabditis elegans via Insulin/IGF-1 Signaling Pathway -
J Gerontol A Biol Sci Med Sci. 2016 Jul 4 - "Coffee and
tea, two of the most popular drinks around the world, share many in common from
chemical components to beneficial effects on human health. One of their shared
components, the polyphenols, most notably chlorogenic acid (CGA), was supposed
to account for many of the beneficial effects on ameliorating diseases occurred
accompanying people aging, such as the antioxidant effect and against diabetes
and cardiovascular disease ... We found that CGA could extend the lifespan of C.
elegans by up to 20.1%, delay the age-related decline of body movement, and
improve stress resistance"

Chlorogenic Acid Extends
the Lifespan of Caenorhabditis elegans via Insulin/IGF-1 Signaling Pathway -
J Gerontol A Biol Sci Med Sci. 2016 Jul 4 - "Coffee and
tea, two of the most popular drinks around the world, share many in common from
chemical components to beneficial effects on human health. One of their shared
components, the polyphenols, most notably chlorogenic acid (CGA), was supposed
to account for many of the beneficial effects on ameliorating diseases occurred
accompanying people aging, such as the antioxidant effect and against diabetes
and cardiovascular disease ... We found that CGA could extend the lifespan of C.
elegans by up to 20.1%, delay the age-related decline of body movement, and
improve stress resistance"

Chlorogenic
acid and caffeine in combination inhibit fat accumulation by regulating hepatic
lipid metabolism-related enzymes in mice - Br J Nutr. 2014
Sep;112(6):1034-40 - "chlorogenic acid (CGA) ... forty
mice were randomly assigned to four groups and fed diets containing no CGA or
caffeine, CGA, caffeine, or CGA+caffeine for 24 weeks ... There was a decrease
in the body weight and IPAT weight of mice fed the CGA+caffeine diet. There was
a significant decrease in the serum and hepatic concentrations of total
cholesterol, TAG and leptin of mice fed the CGA+caffeine diet ... These results
indicate that CGA+caffeine suppresses fat accumulation and body weight gain by
regulating the activities and mRNA and protein expression levels of hepatic
lipid metabolism-related enzymes and that these effects are stronger than those
exerted by CGA and caffeine individually" - See
green coffee bean extract at Amazon.com.

Cognitive
and neuroprotective effects of chlorogenic acid - Nutr Neurosci. 2014 Aug 17
- "chlorogenic acid (CGA) ... A literature search was
conducted using PubMed ... Recent research suggests that dietary consumption of
CGA could produce a wide range of health benefits and physiological effects.
There is also mounting evidence that the consumption of polyphenols, including
CGA, in the diet could reduce the risk of developing neurodegenerative
conditions"

Chlorogenic acid
- Wikipedia - "Chlorogenic acid can be found in
bamboo Phyllostachys edulis.[8] as well as in many other plants.[9] It is
one of the major phenolic compounds identified in peach[10] and in
prunes.[11] It also is one of the phenols found in green coffee bean
extract"