Morgan was cast in a new project by Grey's Anatomy creator Shonda Rhimes. The series, tentatively titled "Correspondents", was to have started production in summer 2007. ABC picked up a spin-off of Grey's Anatomy, called Private Practice, that was also created by Rhimes, and that project has rendered the future of "Correspondents" uncertain. Morgan is also among the cast of a movie that is based on a novel by the Irish novelist Cecelia Ahern, P.S. I Love You. He took a crash course on how to play the guitar for his part in the film, and was excited to find out that the producers had gotten Nancy Wilson of Heart to train him, since, by his own admission, he "had a huge crush" on her since childhood. The film was released on December 21, 2007. Another 2007 film starring Morgan is The Accidental Husband, which finished filming in New York City in March 2007 and was not released on DVD until 2009.

In 2012, Morgan starred in the television drama series Magic City, which centered on mob life in 1950s Miami. The series premiered on April 6 and was cancelled after two seasons.[5] The same year, Morgan appeared in the horror thriller The Possession, and the war film Red Dawn.

In January 2014, it was announced that Morgan had been cast in the lead role in Jonás Cuarón's Desierto.[6] In November, 2014, it was announced that Morgan had been cast as Joe DiMaggio opposite Kelli Garner as Marilyn Monroe in “Marilyn”, a Lifetime four-hour miniseries based on J. Randy Taraborrelli's book, The Secret Life of Marilyn Monroe, which was filmed in Toronto, Ontario, December 2014-February 2015. [7]

Morgan was briefly engaged to his former Weeds costar Mary-Louise Parker in 2008.[8] The engagement ended in April 2008.[9] In 2009, a former girlfriend, actress Sherrie Rose, alleged that Morgan was her son's father. The boy, named Dean Morgan, was four years old when Morgan supposedly learned about him according to tabloids.[10] Morgan began a relationship with actress Hilarie Burton in 2009. The couple has a son, Augustus, born in March 2010 and were married in 2014.[11][12]