Stephanomeria malheurensis has been examined in a series of studies (L. D. Gottlieb 1973b, 1977, 1978b, 1979, 1991; Gottlieb and J. P. Bennett 1983; S. Brauner and Gottlieb 1987, 1989; B. A. Bohm and Gottlieb 1989) because it is one of the very few examples of the recent, natural origin of a diploid, annual plant species. At the type locality, it grows with a population of S. exigua subsp. coronaria that is thought to be its progenitor.

Stephanomeria malheurensis is known from a single locality in Harney County, Oregon, growing in soil derived from volcanic tuff in the high desert of eastern Oregon. It is a federally listed rare and endangered species, and is in the Center for Plant Conservation’s National Collection of Endangered Plants.