As filed with the Securities and Exchange Commission on February 21, 2013

1933 Act Registration No. 333-33607

1940 Act Registration No. 811-08333

UNITED STATES

SECURITIES AND
EXCHANGE COMMISSION

Washington, D.C. 20549

Form N-1A

REGISTRATION STATEMENT UNDER THESECURITIES ACT OF 1933

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Pre-Effective Amendment No.

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Post-Effective Amendment No. 90

x

and/or

REGISTRATION STATEMENT UNDER THEINVESTMENT COMPANY ACT OF 1940

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Amendment No. 91

x

Nuveen Investment Trust II

(Exact Name of Registrant as Specified in Declaration of Trust)

333 West Wacker Drive, Chicago, Illinois

60606

(Address of Principal Executive Offices)

(Zip Code)

Registrants Telephone Number, Including Area Code: (312) 917-7700

Kevin J. McCarthy

Vice President and Secretary

333 West Wacker Drive

Chicago, Illinois 60606

(Name and
Address of Agent for Service)

Copies to:

Eric F. Fess

Chapman and Cutler LLP

111 West Monroe Street

Chicago,
Illinois 60603

Approximate Date of Proposed Public Offering: As soon as practicable after effectiveness.

It is proposed that this filing will become effective (check appropriate box):

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immediately upon filing pursuant to paragraph (b)

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on (date) pursuant to paragraph (a)(1)

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on (date) pursuant to paragraph (b)

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75 days after filing pursuant to paragraph (a)(2)

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60 days after filing pursuant to paragraph (a)(1)

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on (date) pursuant to paragraph (a)(2) of Rule 485.

If appropriate, check the following box:

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This post-effective amendment designates a new effective date for a previously filed post-effective amendment.

This filing relates solely to the following Funds, each a series of the Registrant:

Nuveen Symphony International Equity Fund

Nuveen Symphony Large-Cap Growth Fund

Nuveen Symphony Mid-Cap Core Fund

Nuveen Symphony Optimized Alpha Fund

SIGNATURES

Pursuant to the requirements of the Securities Act of 1933, as amended, and the Investment Company Act of 1940, as amended, the Registrant certifies that it meets all of the requirements for effectiveness of
this registration statement under Rule 485(b) under the Securities Act of 1933, as amended, and has duly caused this post-effective amendment to its registration statement to be signed on its behalf by the undersigned, duly authorized, in the City
of Chicago and State of Illinois, on the 21st day of February, 2013.

NUVEEN INVESTMENT TRUST II

By:

/S/ KEVIN J. MCCARTHY

Kevin J. McCarthy

Vice President
and Secretary

Pursuant to the requirements of the Securities Act of 1933, as amended, this post-effective amendment to the registration
statement has been signed below by the following persons in the capacities and on the date indicated.

Signature

Title

Date

/S/ STEPHEN D.
FOY

STEPHEN D. FOY

Vice President and Controller (principal financial and accounting officer)

February 21, 2013

/S/ GIFFORD R. ZIMMERMAN

GIFFORD R. ZIMMERMAN

Chief Administrative Officer (principal executive officer)

February 21, 2013

ROBERT P. BREMNER*

Chairman of the Board and Trustee

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By:

/S/ KEVIN J. MCCARTHY

KEVIN J.
MCCARTHY

Attorney-in-Fact

February 21, 2013

JOHN P. AMBOIAN*

Trustee

JACK B. EVANS*

Trustee

WILLIAM C. HUNTER*

Trustee

DAVID J. KUNDERT*

Trustee

WILLIAM J. SCHNEIDER*

Trustee

JUDITH M. STOCKDALE*

Trustee

CAROLE E. STONE*

Trustee

VIRGINIA L. STRINGER*

Trustee

TERENCE J. TOTH*

Trustee

*

An original power of attorney authorizing, among others, Kevin J. McCarthy and Gifford R. Zimmerman to execute this registration statement, and amendments thereto, for each of
the trustees of the Registrant on whose behalf this registration statement is filed, has been executed and has previously been filed with the Securities and Exchange Commission and is incorporated by reference herein.