Almost any filler can produce a granuloma but the most common are those that contain polymers. artefill contains plexiglass and in my opinion should never be used as it is a permanent filler. the granuloma with this can be injected with triamcinolone but may have to be surgically removed. any other filler can produce a granuloma, which is a foreign body reaction and can be treated with IL steroids.overe the 30 years i have been doinjg this i have seen granulomas from even collagen injections but not very common. one mistake injectors make is to think any lump is a granuloma, whereas most are simply overcorrection. it is also important to remember that a granuloma is not an allergic reaction.