When a crayfish is given a sudden visual or tactile stimulus to the front part of the animal, the MG activates fast flexor motor neurons that cause the abdomen to flex, resulting in the crayfish moving directly backward, away from the source of the stimulation. This connection was first demonstrated by C. A. G. Wiersma in the red swamp crayfish, Procambarus clarkii.

The medial giant interneurons are less well studied than the lateral giant neurons, which trigger a similar escape behavior.