A possible oncogene and transcriptional activator, JUND is part of the AP-1 redox-regulated transcription complex that may play a role in some age-related changes [ 10978675]. The exact relation of AP-1 to human ageing is unclear, however. Mice lacking junD exhibited persistent hypoglycemia due to enhanced insulin secretion and features of premature aging (cataracts, slight hair loss, graying, varying degrees of cachexia, and lordokyphosis), and had a shortened lifespan [ 18249171]. An impaired activation of AP-1 and altered expression of constituent proteins in adrenal nuclear extracts from rats was also observed during ageing [ 11389931]. A similar change was seen during the ageing of human fibroblasts [ 11557282].

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