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The Reds overcame a 5-0 deficit in the second game, sending Chicago to its fifth straight loss.

Bruce doubled home the tying run in the eighth. Billy Hamilton then had a broken-bat RBI single in the ninth off Hector Rondon (1-3) for the Reds' first doubleheader sweep since 2009 against Pittsburgh.

The Cubs have been swept in all three of their doubleheaders this season. They haven't won a game since trading starters Jeff Samardzija and Jason Hammel to Oakland for a package of prospects.

In the opener, Bruce returned to right field and hit another two-run homer, connecting off Travis Wood (7-7) during a three-run first inning.

Johnny Cueto (9-6) extended his stretch of success against the Cubs. He is 5-0 in his last seven starts against Chicago with a 1.19 ERA.

Chris Coghlan homered in both games and helped the Cubs get in position for a split, but Chicago's bullpen couldn't hold on.

Coghlan hit the first of three homers off left-hander David Holmberg, who lasted only 2 2-3 innings in his Reds debut. Coghlan is 7 for 12 in the series with two homers and two doubles.

Left-hander Tsuyoshi Wada made his major league debut and gave up an unearned run in five innings, leaving with a 5-1 lead. Hamilton's RBI triple cut it to 5-4 in the seventh, and Bruce - playing first base in the nightcap - had another pivotal extra-base hit against Pedro Strop.

Rondon gave up a pair of singles to open the ninth, and Hamilton singled to the opposite field for the win.

The Reds put first baseman Joey Votto back on the disabled list before Game 1, hoping a strained muscle above his left knee will heal enough to let him play this season. They're using different players - including Bruce - at the position for now.

Bruce played right field in the first game and connected in the first inning off Wood. That made three straight games in which the left-handed hitter had a two-run homer off a lefty.

Bruce has 50 homers off lefties during the last five seasons, the most by any player in the majors.

Cueto gave up six hits in 6 1-3 innings, including back-to-back homers in the sixth by Coghlan and Ryan Sweeney.

Manny Parra pitched out of a one-out, bases-loaded threat in the seventh. Aroldis Chapman gave up a hit and a walk in the ninth while getting his 18th save in 20 chances.