Identification of a non-traditional pathway for spiriting a cancer-promoting protein into the cell nucleus points to a possible combination therapy for esophageal cancer and indicates a mechanism of resistance for new drugs that attack the Hedgehog pathway.

Baylor College of Medicine researchers presented new data regarding breast cancer stem cells, the unique subset of breast cancer cells that are capable of initiating tumor growth and are relatively resistant to chemo and radiotherapies.

A pivoted catch designed to fall into a notch on a ratchet wheel so as to allow movement in only one direction (e.g. on a windlass or in a clock mechanism), or alternatively to move the wheel in one direction.