Fusion

STRING allows inspection of the interaction evidence for any given network. Choose any of the viewers above (disabled if not applicable in your network).

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:query proteins and first shell of interactors

white nodes:second shell of interactors

Node Content

empty nodes:proteins of unknown 3D structure

filled nodes:some 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

Slin_0098

Integrase family protein (298 aa)

Predicted Functional Partners:

ruvB

Holliday junction DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (342 aa)

0.755

Slin_5336

Integrase family protein (378 aa)

0.755

Slin_3281

Integrase family protein (372 aa)

0.739

ruvC

Crossover junction endodeoxyribonuclease RuvC; Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5’-terminal phosphate and a 3’-terminal hydroxyl group (182 aa)

0.728

Slin_3649

Cobyrinic acid ac-diamide synthase (317 aa)

0.722

Slin_0241

Cobyrinic acid ac-diamide synthase (300 aa)

0.715

ruvA

Holliday junction DNA helicase RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (198 aa)

Holliday junction DNA helicase RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB

0.691

Slin_0098

ruvB

Slin_0098

Slin_5229

Integrase family protein

Holliday junction DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing

0.755

Slin_0098

ruvC

Slin_0098

Slin_2240

Integrase family protein

Crossover junction endodeoxyribonuclease RuvC; Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5’-terminal phosphate and a 3’-terminal hydroxyl group

0.728

Slin_0241

Slin_0098

Slin_0241

Slin_0098

Cobyrinic acid ac-diamide synthase

Integrase family protein

0.715

Slin_0241

Slin_5855

Slin_0241

Slin_5855

Cobyrinic acid ac-diamide synthase

Cell division protein FtsK

0.633

Slin_3281

Slin_0098

Slin_3281

Slin_0098

Integrase family protein

Integrase family protein

0.739

Slin_3649

Slin_0098

Slin_3649

Slin_0098

Cobyrinic acid ac-diamide synthase

Integrase family protein

0.722

Slin_3649

Slin_5855

Slin_3649

Slin_5855

Cobyrinic acid ac-diamide synthase

Cell division protein FtsK

0.497

Slin_5336

Slin_0098

Slin_5336

Slin_0098

Integrase family protein

Integrase family protein

0.755

Slin_5855

Slin_0098

Slin_5855

Slin_0098

Cell division protein FtsK

Integrase family protein

0.625

Slin_5855

Slin_0241

Slin_5855

Slin_0241

Cell division protein FtsK

Cobyrinic acid ac-diamide synthase

0.633

Slin_5855

Slin_3649

Slin_5855

Slin_3649

Cell division protein FtsK

Cobyrinic acid ac-diamide synthase

0.497

Slin_5855

ruvA

Slin_5855

Slin_4502

Cell division protein FtsK

Holliday junction DNA helicase RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB

0.689

page 1 of 3

Network Stats

Network Stats analysis is still ongoing, please wait ...

Functional enrichments in your networkNote: some enrichments may be expected here (why?)

Enrichment analysis is still ongoing, please wait ...

Statistical background

For the above enrichment analysis, the following statistical background is assumed: