DrugPatentWatch Database Preview

Details for Patent: ► Subscribe

Details for Patent: ► Subscribe

Title:

2-amino-1,3-propanediol compound and immunosuppressant

Abstract:

A 2-amino-1,3-propanediol compound represented by general formula (I) or a pharmaceutically acceptable salt thereof, and an immunosuppressant containing the same as the active ingredient. In said formula R represents optionally substituted linear or branched carbon chain, optionally substituted aryl or optionally substituted cycloalkyl; and R.sup.2, R.sup.3, R.sup.4 and R.sup.5, which may be the same or different from one another, represent each hydrogen, alkyl, aralkyl, acyl or alkoxycarbonyl. The compound is immunodepressant and useful as an inhibitor against rejection in organ or bone marrow transplantation, as a preventive or remedy for autoimmune diseases and so forth, or a reagent in the medical and pharmaceutical fields. ##STR1##

1. A 2-amino-1,3-propanediol compound of having the formula ##STR437## wherein Ra is a straight- or branched chain alkyl having 12 to 22 carbon atoms, which may have, in the chain, a bond or a hetero atom selected from the group consisting of a double bond, a triple bond, oxygen, sulfur, sulfinyl, sulfonyl, --N(R.sup.6)-- where R.sup.6 is hydrogen, alkyl, aralkyl, acyl or alkoxycarbonyl, and carbonyl, and which may have, as a substituent, alkoxy, alkenyloxy, alkynyloxy, aralkyloxy, acyl, alkylamino, alkylthio, acylamino, alkoxycarbonyl, alkoxycarbonylamino, acyloxy, alkylcarbamoyl, nitro, halogen, amino, hydroxyimino, hydroxy or carboxy, and

R.sup.2 b, R.sup.3 b, R.sup.4 b and R.sup.5 b are the same or different and each is a hydrogen, an alkyl or an acyl; or a pharmaceutically acceptable salt thereof.

2. A 2-amino-1,3-propanediol compound of claim 1, having the formula ##STR438## wherein Rb is a straight- or branched chain alkyl having 13 to 20 carbon atoms, which may have, in the chain, an oxygen atom and which may have, as a substituent, nitro, halogen, amino, hydroxy or carboxy, and

R.sup.2 c and R.sup.3 c are the same or different and each is a hydrogen or an alkyl, or a pharmaceutically acceptable salt thereof.

3. A 2-amino-1,3-propanediol compound of claim 1 or 2, having the formula ##STR439## wherein Rc is a straight-or branched chain alkyl having 13 to 20 carbon atoms or a straight- or branched chain alkyl having 13 to 20 carbon atoms which is substituted by halogen, or a pharmaceutically acceptable salt thereof.

4. A 2-amino-1,3-propanediol compound of any one of claims 1 or 2, which is selected from the group consisting of

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors.
Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data.
The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free.
thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user.
Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.