* Industrials firmed 0.3 percent, with Waste Connections Inc up 1.2 percent at C$87.86 after two analysts raised their price target on the stock.

* The biggest gainer on the index was Prometic Life Sciences Inc , which rose 8.5 percent to C$1.53.

* Six of the index’s 10 main groups were lower.

* The energy group, which had rallied as much as 11.9 percent since mid-December, fell 0.7 percent. Encana Corp was down 2.3 percent at C$16.91.

* U.S. crude prices were little changed at $61.66 a barrel.

* The largest decliner on the TSX was Aphria Inc, down 10.3 percent at C$19.25. Another marijuana producer, Canopy Growth Co, fell 9.9 percent to $32.34.

* The U.S. Department of Justice on Thursday will rescind an earlier marijuana policy under former Democratic President Barack Obama that eased enforcement of federal laws amid a growing number of local legalization efforts, according to a source familiar with the change. (Reporting by Fergal Smith; Editing by Jonathan Oatis)