Not tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Target

Function

Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates INFG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases.

Tissue specificity

Present in most normal tissues. Higher expression observed in epithelial cells with secretory and excretory functions, as well as in cells chronically exposed to xenobiotics, such as bronchial cells and cells lining the intestine. Overexpressed in many multidrug-resistant cancer cells.

Thank you for your patience.
I have received a reply from the originator of ab3367 (MVP antibody [LRP-56]), this antibody is an IgG2b kappa.
Please don't hesitate to contact us again if you have further questions.

Thank you for your enquiry; having looked into the problem it appears that this clone has been duplicated in our catalogue in error. I have removed the product added most recently to our catalogue and kept the long standing Ab3367.If you have any furth...