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This interdisciplinary symposium will convene leading experts in adult stem cell research, tissue regeneration and bioengineering to discuss cutting edge research at the intersection of these disciplines, with the overall aim of translating current stem cell knowledge into clinical applications.

Grantsmanship for Students and Postdocs: Pathways to Individual Fellowship

March 20, 2019

Join Science Alliance for “Grantsmanship for Graduate Students and Postdocs” to learn the skills for concise and persuasive writing that is not only vital in academia, but essential for any career path.

This two-day symposium will convene leading experts in cancer immunotherapy to discuss cutting-edge findings in the broad area of combination therapies, including checkpoint inhibitors and cellular therapies. Particular emphasis will be given to the biological mechanisms underlying combination hypotheses, bispecific antibodies and other emerging modalities for delivery of combination therapies, as well as a discussion of the importance of effective clinical trial design.

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Join Dr. Rebecca Nebel from the Society for Women’s Health Research and the Science Alliance to learn more about how to utilize informational interviews for career exploration, networking, and finding the job of your dreams.

Join us at the Academy to learn directly from a PhD hiring manager what they look for in a resume, the best way to communicate technical and transferable skills to a mixed audience, and how to showcase not just what you do but who you are and why an employer should want to hire you.

This panel will highlight the realities of a career change and the opportunities available to scientists who are thinking about a career in teaching. Our guests will discuss what it’s really like to teach in public schools, the shift in culture from a lab to a classroom, and the programs that will help prepare you to get there.

The Junior Academy recruits STEM experts to coach teams of talented, highly motivated students as they compete in science & technology challenges sponsored by industry-leading companies. Students and mentors can participate from anywhere in the world, connecting with one another via Launchpad, our interactive challenge platform.

Available exclusively to our Member community, Member-to-Member Mentoring is a self-directed mentoring program that matches early career scientists and engineers with experienced STEM professionals for advice and coaching.

In this Annals issue, leading scientists and scholars explore the question of meaning through the lens of scientific inquiry, using interdisciplinary approaches to examine the various sources from which we might derive greater insight into the meaning and purpose of human existence.

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For 200 years—since 1817—the Academy has brought together extraordinary people working at the frontiers of discovery. Among the oldest scientific organizations in the United States, it has become not only an enduring cultural institution in New York, but also one of the most significant organizations in the global scientific community.

Nanomaterials and Biocompatibility

The Nanobiotechnology Discussion Group meets periodically to explore research at the interface between the biological and chemical/physical sciences in the emerging field of nanoscience. Meetings feature talks from leading junior and senior investigators working in this dynamic and interdisciplinary field.

Program

5:00 pm - 7:30 pm: Presentations

Matthew Becker, National Institute of Standards and Technology, "Measurement Challenges at the Cell-material Interface: Differentiating at the Nanoscale."

David Warheit, DuPont, "Impact of Nanoparticulates on Respiratory Health Effects: Toxicity is Not Always Dependent Upon Particle Size and Surface Area."

Vicki Colvin, Rice University, "Eco-Nano: The Impact of Engineered Nanomaterials on the Environment."

Abstracts

"Measurement Challenges at the Cell-material Interface: Differentiating at the Nanoscale"Matthew Becker A robust framework outlining the critical interactions that govern the biocompatibility of nanomaterials does not exist, but is desperately needed. New synthetic methods are creating increasingly complex bio- and nanomaterials with regiochemical and stoichiometic control over the functional groups. These materials demand a multidisciplinary approach to identify and develop strategies to both characterize and control cell-material interactions. As the size of the nanomaterial and the corresponding number of bio-molecular interaction sites decrease, high levels of precise characterization are required for meaningful bio-measurements. This presentation will highlight several examples of recent and ongoing research efforts within our group that demonstrate how precise measurements are able to discriminate between species possessing very small physico-chemical variations and how these incremental differences drastically influence the measured biological outcomes.

"Impact of Nanoparticulates on Respiratory Health Effects: Toxicity Is Not Always Dependent Upon Particle Size and Surface Area"David Warheit The results of several lung toxicology studies in rats have demonstrated that ultrafine or nanoparticles (generally defined as particles in the size range <100 nm) administered to the lungs produce enhanced inflammatory responses when compared to fine-sized particles of similar chemical composition at equivalent doses. However, the common perception that nanoparticles are always more toxic than fine-sized particles is based upon a systematic comparison of only two particle-types, namely, titanium dioxide and carbon black particles. Apart from particle size and corresponding surface area considerations, several additional factors may play more important roles in influencing the pulmonary toxicity of nanoparticles. These include, but are not limited to: 1) surface treatments/coatings of particles; 2) the aggregation/disaggregation potential of aerosolized particles; 3) the method of nanoparticle synthesis—i.e., whether the particle was generated in the gas or liquid phase (i.e., fumed vs. colloidal/precipitated); 4) translocation potential of the particle; 5) particle shape; and 6) surface charge.