Many cases that on microscopic examination prove to be AD have an undistinguished external appearance with either mild, generalized frontotemporal atrophy not greater than that seen in aged brains or have no detectable atrophy at all.

Changes in gene expression, specifically of regulatory neurodevelopmental genes, may have altered the developmental trajectory of vulnerable frontoparietal and frontotemporal cortical circuitry over millennia, resulting in aberrant connectivity in the evolution of mans' highly complex social brain.

26, 2007, issue of the <em>Journal of Neuroscience</em>, demonstrates for the first time a pathological pathway that ultimately results in cell death related to frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS, also known as Lou Gehrig's disease).

By studying the role of Tau in human cells, the company aims to advance a novel therapeutic into the clinic for multiple tauopathies (Alzheimer's disease, Frontotemporal Dementia, Progressive Supranuclear Palsy (PSP) and others).

In patient-derived stem cells carrying a mutation predisposing them to frontotemporal dementia, which accounts for about half of dementia cases before the age of 60, the scientists found a targetable defect that prevents normal neurodevelopment.

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