Lispro Mix 25 vs. Glargine in Type 2 Diabetics

Summary

In patients with type 2 diabetes who have not been on insulin therapy before the study will
achieve better glycemic control by the treatment regiment consisting of two times daily
insulin lispro mix 25 than by the treatment regiment with consisting of one time daily
injection of insulin glargine. Improved glycemic control will be compared by the fasting
plasma glucose and blood glucose excursions 2 hours after breakfast.

Description

The objective of this study is to investigate which type of insulin regimen is the best way
to achieve best glycemic control in early type 2 diabetes. Patients with diabetes mellitus
type 2 with a duration of diabetes between 1 and 10 years without previous insulin therapy
will be randomized on insulin lispro mix 25 or insulin glargine therapy. Glycemic control
will be compared by the between treatment difference in fasting plasma glucose and 2h
postprandial blood glucose excursions (preprandial -postprandial excursions) after
breakfast.

Conservatively, over 1 million people have been diagnosed with diabetes mellitus in Australia, the majority with type 2 diabetes mellitus (T2DM). Until the progressive decline in pancreatic beta cell ...

Over the past few decades, continuous progress has been made in the development of insulin therapy. Basal insulins were developed around 60 years ago. However, existing basal insulins were found to ha...

Air pollution is a novel risk factor for insulin resistance and occurrence of type 2 diabetes mellitus (T2DM), but the evidence is limited and diverse. Therefore, the aim of this study was to assess t...

Medical and Biotech [MESH] Definitions

Diabetes Mellitus, Type 2

A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.

Diabetes Mellitus, Type 1

A subtype of DIABETES MELLITUS that is characterized by INSULIN deficiency. It is manifested by the sudden onset of severe HYPERGLYCEMIA, rapid progression to DIABETIC KETOACIDOSIS, and DEATH unless treated with insulin. The disease may occur at any age, but is most common in childhood or adolescence.

Insulin

A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1).

Prediabetic State

The time period before the development of symptomatic diabetes. For example, certain risk factors can be observed in subjects who subsequently develop INSULIN RESISTANCE as in type 2 diabetes (DIABETES MELLITUS, TYPE 2).

Rats, Inbred Bb

A strain of Rattus norvegicus which is a model for spontaneous insulin-dependent diabetes mellitus (DIABETES MELLITUS, INSULIN-DEPENDENT).

More From BioPortfolio on "Lispro Mix 25 vs. Glargine in Type 2 Diabetics"