For the 22nd time since Bill Belichick took over the team, the New England Patriots will be going up against an opponent starting a rookie quarterback.

Historically, it hasn't gone well for the rookies. Since Belichick came to New England in 2000, the Patriots are 16-5 when facing teams who are starting rookies at quarterback.

The Houston Texans will visit Gillette Stadium with 2017 first-round pick Deshaun Watson set to start under center. Watson is fresh off a 16-9 win over the Cincinnati Bengals last week in a solid performance.

We won't know how Watson will do against the Patriots until Sunday. However, we can look at trends to see how other rookies have done in the past.

2001: Week 8 at Falcons - Michael Vick (Didn't Start)

AP Photo/MARY ANN CHASTAIN

Stat line:

2-of-9

56 yards

3 sacks

53.0 QB rating

2 rushes

50 yards

WIN: Patriots 24 - Falcons 10

Vick didn't start this game. He only played for a little more than a quarter at the end of the game in relief of Chris Chandler. It's one of the first notable examples of a Belichick team faring well against a rookie. It wouldn't be the last.