(In Septic shock the due to vasodilation skin may feel warm and flushed).

Coronary & Cerebral vessels are less responsive to above mechanisms and hence maintain their blood flow.

[2]PROGRESSIVE STAGE:

In this stage there is widespread HYPOXIA leading to Anaerobic glycolysis with excessive production of lactic acid.. Lactic Acidosis lowers pH and blunts the above Vasomotor Response.—so, the arterioles dilate and blood begins to pool in microcirculation. This reduces CO. Also, exposes endothelial cells to injury and subsequent development of DIC.

Hypoxia to Brain makes pt. Confused, and to kidney causes decline in UO