Artificially-intelligent Robot Scientist ‘Eve’ could boost search. http://www.sysbiol.cam.ac.uk/news/artificially-intelligent-robot-scientist-2018eve2019-could-boost-search
"[Eve's artificial intelligence] reduces the costs, uncertainty, and time involved in drug screening, and has the potential to improve the lives of millions of people worldwide" - Steve Oliver

]]>No publisherPetra Ghassemi-Ahari2015-02-20T15:35:00ZNews Item BBSRC Big Data Award to the Carazo Salas grouphttp://www.sysbiol.cam.ac.uk/news/Big%20Data
Carazo Salas group involved in a new BBSRC Big Data Award to build a next generation image data repository, led by Dundee's Jason Swedlow and in collaboration with EBI/ELIXIR's Alvis BrazmaSee the full news here and here

The UK's Biotechnology and Biological Sciences Research Council has invested £7.5M in new infrastructure to tackle bioscience big data challenges. The new funding will improve the storage and curation of enormous datasets that will unlock untold discoveries in important areas like health, agriculture and sustainable fuels.

Biological discovery is increasingly being driven by ground-breaking technologies, such as high-throughput genomic analysis and next generation biological imaging, which generate massive and complex datasets. In order to investigate complex biological phenomena, researchers need access to comprehensive, integrated data resources that are accessible for the whole community.

Access to primary research data is vital for the advancement of science; to validate existing observations and provides the raw materials for new discoveries. Sharing data in a standardised way can enable exciting breakthroughs as researchers interrogate big data sets to spot undiscovered patterns of biological importance.

However, many biologists, and in some areas the community as a whole, struggle to take full advantage of the data generated because of a lack of computing resource, appropriate support and technical skill.

To meet these challenges, BBSRC is strengthening investment in bioinformatics and biological resources, focusing on the needs of the research community, and facilitating the development of sustainable models of operation.

]]>No publishergf247@cam.ac.uk2015-02-16T09:00:46ZNews ItemKeller, Turchyn & Ralser's non-enzymatic glycolysis paper selected as a ‘cutting edge chemistry in 2014’ paper by Chemistry World 2014, 10th Dec 2014. http://www.sysbiol.cam.ac.uk/news/keller-turchyn-ralsers-non-enzymatic-glycolysis-paper-selected-as-a-2018cutting-edge-chemistry-in-20142019-paper-by-chemistry-world-2014-10th-dec-2014
Cutting Edge Chemistry in 2014, Chemistry World, 10 Dec, 2014:Keller, M.A., Turchyn, A.V. and Ralser, M. (2014) Non‐enzymatic glycolysis and pentose phosphate pathway‐like reactions in a plausible Archean ocean. Molecular Systems Biology 10:725 [doi: 10.1002/msb.20145228] ]]>No publisherPetra Ghassemi-Ahari2015-01-19T10:10:00ZNews ItemProfessor Steve Oliver has been identified as one of the Great British Bioscience Pioneers by BBSRC.http://www.sysbiol.cam.ac.uk/news/professor-steve-oliver-nominated-one-of-the-great-british-pioneers-by-the-bbscr
Continuing the series of Great British bioscience pioneers, BBSRC speaks to Professor Steve Oliver from The University of Cambridge whose work to study the genetics of the yeast Saccharomyces cerevisiae has led to discoveries in diverse areas of bioscience. Read the full story in the BBSRC website:]]>No publishergf247@cam.ac.uk2014-11-11T16:30:00ZNews ItemResearch at the CSBC reveals that the TRiC/CCT Chaperone Is Implicated in Alzheimer's Disease Based on Patient GWAS and an RNAi Screen in Aβ-Expressing Caenorhabditis eleganshttp://www.sysbiol.cam.ac.uk/news/research-at-the-csbc-reveals-that-the-tric-cct-chaperone-is-implicated-in-alzheimers-disease-based-on-patient-gwas-and-an-rnai-screen-in-ab-expressing-caenorhabditis-elegans
The human Aβ peptide causes progressive paralysis when expressed in the muscles of the nematode worm, C. elegans. We have exploited this model of Aβ toxicity by carrying out an RNAi screen to identify genes whose reduced expression modifies the severity of this locomotor phenotype. Our initial finding was that none of the human orthologues of these worm genes is identical with the genome-wide significant GWAS genes reported to date (the “white zone”); moreover there was no identity between worm screen hits and the longer list of GWAS genes which included those with borderline levels of significance (the “grey zone”). This indicates that Aβ toxicity should not be considered as equivalent to sporadic AD. To increase the sensitivity of our analysis, we then considered the physical interactors (+1 interactome) of the products of the genes in both the worm and the white+grey zone lists. When we consider these worm and GWAS gene lists we find that 4 of the 60 worm genes have a +1 interactome overlap that is larger than expected by chance. Two of these genes form a chaperonin complex, the third is closely associated with this complex and the fourth gene codes for actin, the major substrate of the same chaperonin.

]]>No publishergf247@cam.ac.uk2014-08-08T11:20:24ZNews ItemResearch at the Cambridge Systems Biology centre reveals how first organisms could have obtained a metabolic network.http://www.sysbiol.cam.ac.uk/news/research-at-the-cambridge-systems-biology-centre-reveals-how-first-organisms-could-have-obtained-a-metabolic-network
The sugar phosphate reaction sequences of glycolysis and the pentose phosphate pathway supply modern cells with the intermediates required for the synthesis of RNA, lipids and amino acids. Today, these reactions are catalysed by sophisticated metabolic enzymes, but a new study by Keller, Turchyn and Ralser published in Molecular Systems Biology shows that the origin of these pathways could have been much simpler. Replicating conditions of an Archean sea, considering conditions of the eon before the atmosphere was oxygenated (~3.5- 4 billion years ago) they could find reactions which mimic glycolysis and the pentose phosphate pathway to occur also in the absence of enzymes. This finding triggers the hypothesis that first forms of metabolism were of environmental, or pre-biotic origin, and proposes that the origin metabolism could have been an early event during the origin of life.

]]>No publisherPetra Ghassemi-Ahari2014-04-30T10:55:00ZNews Itemesyn.org Released!http://www.sysbiol.cam.ac.uk/news/esyN
esyn.org an Easy Networks building tool has been released! esyN.org is a easy to use networks building tool. The user can build either Diagrams or Models. In the Diagrams tool users create graphs of interaction data, allowing interaction networks to be interactively generated and explored. In the Models tool, users create more complex graphs based on the Petri Nets formalism. Users can automatically generate and simulate a Petri Nets model based on their network. For both tools, interaction data is automatically retrieved using InterMine. As a web tool, esyN is also designed to facilitate collaboration on network models and data publication.]]>No publishergf247@cam.ac.uk2014-03-20T14:15:00ZNews ItemThe $ 1000 Genome - A New Dawnhttp://www.sysbiol.cam.ac.uk/news/genome
The US sequencing technology company Illumina has announced that is now possible to sequence an entire human genome for $ 1000. Read the full news in the BBSRC website]]>No publishergf247@cam.ac.uk2014-01-31T08:50:00ZNews ItemNew Publication: C. C. Bouuaert, K. Lipkow, et al., (2013) The autoregulation of a eukaryotic DNA transposon.http://www.sysbiol.cam.ac.uk/news/why-jumping-genes-don2019t-send-us-into-meltdown-new-publication-dr-karen-lipkow
New study on how the movement and duplication of segments of DNA known as transposons is regulated.

Read more in the University News page.]]>No publisherPetra Ghassemi-Ahari2013-07-02T15:25:00ZNews ItemNaked Yeast!http://www.sysbiol.cam.ac.uk/news/naked-yeast
Dr Elizabeth Bilsland has been interviewed by the Naked Scientist.

]]>No publishergf247@cam.ac.uk2013-03-01T09:20:00ZNews ItemNew tool in the fight against tropical diseaseshttp://www.sysbiol.cam.ac.uk/news/new-tool-in-the-fight-against-tropical-diseases
Screening method created to expedite the development of new drugs in the fight against tropical diseases such as malaria and African sleeping sickness. - Read more in the University News page]]>No publishergf247@cam.ac.uk2013-02-27T11:30:00ZNews ItemNew Publicationshttp://www.sysbiol.cam.ac.uk/news/new-publications
Please see links below for new publications.

]]>No publisherhej30@cam.ac.uk2013-01-22T10:25:00ZNews ItemSteve Oliver gave the opening Keynote Lecture at the 1st International Symposium on Microbiology & Biotechnology.http://www.sysbiol.cam.ac.uk/news/steve-oliver-gave-the-opening-keynote-lecture-at-the-1st-international-symposium-on-microbiology-biotechnology
Steve Oliver gave the opening Keynote Lecture at the 1st International Symposium on Microbiology & Biotechnology (SIMB 1) at the Federal University of Viçosa, Minas Gerais, Brazil on December 6th 2012. His lecture was entitled "A yeast for all reasons".