The Fantastic Four wrap up their fight against the Inhumans as the Thing fights Black Bolt to a draw. The Inhumans have more problems than just the FF and Dragon Man. The Seeker is hunting them down and capturing the Inhumans.

Like Medusa, who escaped her own people; the Inhumans have escaped their own world and are living in seclusion and the Seeker looks to take them back to where they belong.

The FF are captured by the Seeker as they learn the origins of the Inhumans. But Dragon Man has awoken from his sleep and no longer trusts humans and he is now loose in a city full of humans.