Sunday, August 31, 2014

Whether you want to lose or gain weight, never forget to "Eat to live!"

To lose weight, you must create a negative energy balance.It is however unrealistic to expect your body not to do everything it can to conserve energy, when you've been eating 50% below maintenance for weeks (e.g. you need 2,000kcal, but eat only 1,000). Not to reduce your energy intake by more than 40% (for max. 2 weeks) and going with 20-25% if you plan to diet for 4-6 weeks would thus qualify as rule #1; a rule of which I can only say that I highly recommend you stick to it, because if you don't even the five tips below are not going to save your metabolism from crashing (learn more about the nine rules that can help avoiding metabolic shut-down).

There is evidence of effects of coffee & CGA on your gut microbiome (Jaquet. 2009)

Fiber for Female Fat Loss

Sweeteners & Your Gut

Foods, Not Ma- cros for the Gut

Lactulose For Gut & Health

Probiotics Don't Cut Body Fat

The Macrobiotic MaPi2.0 Diet

Ah, and before I forget to mention it. If you don't control your dietary energy intake, chances that any of the following tricks (in that case magically) help you lose weight without the need to diet are anywhere between "slim" and "zero".

Eat large meals less frequently: It may go against the
longstanding recommendation, but due to the fact that meal size, not
macro composition is the main determinant of the post-meal increase in
thermogenic effect.

And considering the fact that the latter lasts for 5h+ (see Figure 1)
the idea that you have to eat a small meal every hour "to stoke the
furnace" is fundamentally flawed. No wonder, people all over the world
are successfully using weight by intermittent fasting.

Thermic effect
of food (in kcal/3h), when it's consumed at rest or after a workout in
lean vs. obese (fat, not just heavy) subjects (Segal, 1985)

The thermic effect of food is reduced with obesity: A review of 49 pertinent studies by researchers from the Pennington Biomedical Research Center
clearly indicates "the reduction of TEF in obesity is related to the
degree of insulin resistance, which may be influenced by a low level of
sympathetic activity." (Jonee. 1997). A study by Segal et al. measured a
difference of 42% at rest and 64% if the meal was consumed after a
workout (see figure on the left). Accordingly those of you who are still
carrying more than "some" extra weight should be careful not to
overestimate the benefits of food induced increases in thermogenesis.
Don't misinterpret this as "you got to eat more often", though! This
could make things even worse.

You have to be careful, though, long
arduous workouts during the fast or fasting for more than 12-16h could
nullify the thermogenic benefit of being able to eat to satiety once or
twice a day. And no! The Kinabo study is not a statistical outlier, it's
just like a study with almost identical results by Tai et al. (1991)
real vs. broscience which dictates that you "got to stock the furnace" -
a practice of which the latest controlled studies show that is has "no
significant effect on 24-h fat oxidation, but may increase hunger and
the desire to eat." (Ohkawara. 2013)

Use 4mg/kg caffeine per day - You will certainly have expected to see caffeine on the list of agents that help. Unfortunately, caffeine is significantly more effective for lean vs. overweight individuals. In a study from the Institute of Physiology at the University of Lausanne, David Bracco and colleagues were able to show that the thermogenic effect of caffeine coffee (4mg/kg body weight) was 35.6% more pronounced in the lean vs. obese female subjects (Bracco. 1995) - similar results have been reported by Belza et al. (2007), Hollands et al. (1981) increases of 15% in the two hours after the ingestion of caffeinated vs. decaffeinated coffee.

Figure 2: Relative increase in resting metabolic rate, energy expenditure during exercise and sleep in lean and obese women in response to the ingestion of 4mg/kg of caffeine (vs. placebo | Bracco. 2014)

In addition to the overall effect size, the data in Figure 2 does also indicate that an "over night" effect, as well as the increase in energy expenditure during workouts were likewise only observed in the lean, not in the obese women (since the lack of thermogenesis has been associated with decreased insulin sensitivity using 300-500mg of alpha lipoic acid, as I have suggested in a recent article, may ameliorate the reduction in postprandial thermogenesis).

Remember not to go overboard on caffeine (here's why): Stick to 600mg/day and take it in three to four doses of 200mg or 150mg respectively; and, if possible, get some of it from coffee, for the added benefits of chlorogenic acid & co (McCarty. 2005). In fact, a recent study from the Technische Universität Kaiserslautern shows that coffee consumption 250ml 3x per day (vs. decaffeinated coffee as placebo) will even induce body fat loss(es) in the absence of deliberate restrictions of food intake in 84 healthy subjects... and on top of it, the coffee consumption protected the study participants DNA (Bakuradze. 2014).

Now 4mg/kg may seem like quite a high dosage for some of you. In contrast to the usual SuppVersity mantra that "more won't help more", those 4mg caffeine per kg of body weight are yet well necessary. In a 1999 study from the University of Geneva, for example, the administration of only 50mg of caffeine had no effect on the resting energy expenditure of 10 healthy male volunteers (Dullo. 1999).

Figure 3: Substrate utilization (mg/min) before (filled bars) and after (empty bars) the ingestion of a complex test meal with either coffee (4mg/kg caffeine) or decaffeinated coffee (Acheson. 1980).

Furthermore, caffeine has also been shown to increase the thermic effects of a meal and to shift the fuel utilization towards fatty acids (Acheson. 1980; see Figure 3). The latter will not necessarily help you to burn more body fat, but it will spare liver and muscle glycogen, when you're dieting and reduce the chances that your liver resorts to amino acids from your musculature to cover the glucose requirements of your body.

In conjunction with the net increase in energy expenditure Dullo et al. quantify in the range of 150 kcal in lean volunteers and 79 kcal as a response to the bi-hourly consumption of 100mg of caffeine in the post-obese subjects, there is little doubt that

"Caffeine at commonly consumed doses can have a significant influence on energy balance and may promote thermogenesis in the treatment of obesity." (Dullo. 1989)

Studies by Yoshida et al. support this notion and confirm that the addition of caffeine to the weight loss equation will be particularly effective in overweight individuals with reduced baseline metabolic rate (Yoshida. 1995) and more recent experimental data from the University of Maastricht confirms that high caffeine intakes are associated not just with increased weight loss through thermogenesis and fat oxidation, but also with reduced fat mass, and waist circumference in overweight and moderately obese subjects (Westerterp‐Plantenga. 2005).

You already knew those two? Well in that case you've probably been following my articles here at the SuppVersity for quite some time, now. I have, after all, written about caffeine, coffee, intermittent fasting and meal frequencies, before. And in case you didn't find at least a couple of additional new figures, you haven't seen before, I can comfort you: There will be follow ups in the course of the next weeks.

Additional Ressources

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