It allows you to manage multiple networks, but no it cannot tell the difference between my computer and a coworker's computer making the request. I use the free version (our internal DNS server looks to OpenDNS for lookups). Although I haven't tried their Deluxe or Enterprise offerings, but I don't see how they could determine the individual IP address on your LAN.

The OpenDNS group has a partner listed who is an OpenDNS guy (Ravi (OpenDNS), he likely could give a more definitive answer.

Ditto to what has been said. OpenDNS will only do your external IP or a range of external IPs and if it is NATed to your inside network (which is very common) there would no way to tell what client is actually doing the request from their OpenDNS side. As far as I know the Enterprise edition does not offer this internal IP capability either if that is what you are asking about, although I could be wrong as I do not use that.

I got an email back from OpenDns and I'm now able to block the one PC. On every PC in the office, we enter our DNS servers in tcp/ip properties (Which makes their suggestion very easy to implement). After i added our network to OpenDNS, OpenDNS had me enter their DNS servers on the local PC in question. We are using OpenDNS' Deluxe version by the way.

Wow I didn't know you were on the Spiceworks. Since you are here may I just say I really do appreciate the OpenDNS service. It has really made so many things so much simpler for me to manage. Thank you so friggin much.