RT Journal Article
SR Electronic(1)
A1 MYRICK, ALISSA
A1 LEEMANN, ERIKA
A1 DOKOMAJILAR, CHRIS
A1 HOPKINS, HEIDI
A1 DORSEY, GRANT
A1 KAMYA, MOSES R.
A1 ROSENTHAL, PHILIP J.
YR 2006
T1 DYNAMICS OF PLASMODIUM FALCIPARUM MALARIA AFTER SUB-OPTIMAL THERAPY IN UGANDA
JF The American Journal of Tropical Medicine and Hygiene,
VO 74
IS 5
SP 758
OP 761
DO https://doi.org/10.4269/ajtmh.2006.74.758
PB The American Society of Tropical Medicine and Hygiene,
SN 0002-9637,
AB We followed parasite genotypes of 75 patients for 42 days after treatment of uncomplicated malaria with chloroquine + sulfadoxine-pyrimethamine in Kampala, Uganda. Infections were complex (mean, 2.88 strains) and followed three patterns: 27% of patients eliminated all strains and remained parasite-free, 48% had a long aparasitemic interval followed by reappearance of original strains after 3–33 days (mean, 9.2 days), and 25% failed to clear original strains and required therapy after 3–35 days (mean, 17 days). These results highlight the complexity of malaria in Africa and have implications for efficacy trials, because missing late reappearances of strains could lead to misclassification of outcomes.,
UL http://www.ajtmh.org/content/journals/10.4269/ajtmh.2006.74.758