GI Tract Mucus, Biofilms, Worms

This site has been largely focused on polymicrobial bacterial biofilms, of which this article below may relate. Biofilms are not explicitly mentioned but may be implied.

Biofilms are found throughout nature in many different forms. Mankind will be learning about the ones in our own digestive tracts for decades to come.

Note the Wiki definition of mucins. Also note that the notion of worm diseases being confined to "third world" people is not only a myth; it is somewhat misleading. Many Americans across ALL demographics have been found to have infestations of worms, ranging from the "biggies" like Trichinella spiralis to microfilariae carried and injected into hosts (us, our pets) by ticks, fleas and other little flying cesspools.

Many Americans I've spoken with had tours of duty as soldiers, missionaries or volunteers overseas -- I cannot tell you how many experienced serious health problems which have resulted months or year later. Some patients have had health problems appear acutely -- or chronically -- decades later! Can you fathom this horrible thought? These are documented on PubMed and various documentaries. Just recently, speculation about Darwin's terrible chronic illnesses were related to his interactions with pests near and far; see this news link.

We need much more research devoted to GI parasitology and GI biofilms translated to the clinical environment and point of care. After all, this complex body system is the engine of our immune health.
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One Billion People Worldwide Could Benefit From Worm Discovery

06 May 2011

Scientists have discovered why some people may be protected from harmful parasitic worms naturally while others cannot in what could lead to new therapies for up to one billion people worldwide.

Parasitic worms are a major cause of mortality and morbidity affecting up to a billion people, particularly in the Third World, as well as domestic pets and livestock across the globe.

Now, University of Manchester researchers have, for the first time, identified a key component of mucus found in the guts of humans and animals that is toxic to worms.

"These parasitic worms live in the gut, which is protected by a thick layer of mucus," explained Dr David Thornton, from the University's Wellcome Trust Centre for Cell Matrix Research. "The mucus barrier is not just slime, but a complex mixture of salts, water and large 'sugar-coated' proteins called mucins that give mucus its gel-like properties.

"In order to be able to study these debilitating worm diseases, we have been using a mouse model in which we try to cure mice of the whipworm Trichuris muris. This worm is closely related to the human equivalent,Trichuris trichiura.

"We previously found that mice that were able to expel this whipworm from the gut made more mucus. Importantly, the mucus from these mice contained the mucin, Muc5ac. This mucin is rarely present in the gut, but when it is, it alters the physical properties of the mucus gel."

Co-lead on the study, Professor Richard Grencis, from the Faculty of Life Sciences, continued: "For this new research, we asked how important Muc5ac is during worm infection by using mice lacking the gene for Muc5ac. We found that mice genetically incapable of producing Muc5ac were unable to expel the worms, despite having a strong immune response against these parasites. This resulted in long-term infections.

"Furthermore, we discovered the reason for the importance of Muc5ac is that it is 'toxic' for the worms and damages their health."

The study, published in the Journal of Experimental Medicine and featured in Nature's 'research highlights' yesterday (Thursday), found that Muc5ac is also essential for the efficient expulsion from the gut of other types of worm that cause problems in humans. These include the hookworm, and the spiral threadworm. Together, these worms cause mortality and morbidity in up to one billion people across the globe.

Dr Sumaira Hasnain, the lead experimentalist on the project, added: "For the first time, we have discovered that a single component of the mucus barrier, the Muc5ac mucin, is essential for worm expulsion. Our research may help to identify who is and who isn't susceptible to parasitic worms, and it may eventually lead to new treatments for people with chronic worm infections."