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Transcript

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0:00

Hello.My name is Hironobu Fujiwara.I am currently studying
at the RIKEN Centerfor Developmental
Biology in Kobe, Japan.Today I'd like to talk about
several of the extracellularmatrices, ECM in mammalian skin.

0:18

Here is outline of my talk.First, I'll explain
the general importanceand function of
cell-ECM interactions.Second, I'll talk about the skin
ECM, which comprises a basementmembrane and interstitial matrix.Third, skin ECM heterogeneity.Fourth, ECM-integrin interactions
in epidermal stem cell regulation.And fifth, non-cell-autonomous
functions of the skin ECM.I'll then move on to
the role of the ECMin aging and associated
pathological conditions,followed by perspectives.

0:56

First, I'll talk about
the general importanceand function of
cell-ECM interactions.

1:04

During the developmental of
complex multicellular organs,including the skin, stem,
or progenitor cells,differentiate into
distinct cell types.These cells aggregate into
tissues where they are positionedin the current place,
and simultaneouslyengage in appropriate
cellular interactions.As a result, the
integrated cells establishemergent properties of
a complex organ system.Scientists have long been
investigating the formationof such multicellular assemblies and
the mechanisms that keep the cellsin their proper
place and enable themto develop communication networks.