12/16/2008 @ 4:49PM

In Pictures: America's 25 Biggest Billionaire Losers

Sheldon Adelson

Rank: 1

Wealth lost in 2008: $24 billion

Las Vegas Sands is down 95% as gamblers curtail their spending and Wall Street’s once-sunny hopes for Chinese gambling adjust to reality. The casino mogul recently invested $1 billion of his own cash to bolster the company’s balance sheet.