Argonne National Laboratory, laboratory of the first U.S. Department of Energy national research laboratory, located in Argonne, Ill., that is Illinois, some 40 km (25 miles) southwest of Chicago, and operated by the University of Chicago and for the Argonne Universities Association. U.S. Department of Energy. It was founded in 1946 to conduct basic atomic nuclear physics research and to develop the technology for peaceful uses of nuclear energy. Argonne National Laboratory now carries out research on a broad range of science and engineering topics, including high-temperature superconductors, advanced computers, and the causes and cures of cancersupports more than 200 basic and applied research programs—in science, engineering, and technology—that are directed to maintain basic scientific leadership, guide energy-resource development, improve nuclear-energy technology, and promote environmental-risk management.

The Argonne laboratory houses several major research facilities , one of the most recent being the that are available for collaborative and interdisciplinary use by government, academic, and industrial scientists. Four of these facilities—the Advanced Photon Source (APS), the Intense Pulsed Neutron Source (IPNS), the Argonne Tandem Linear Accelerator System (ATLAS), and the High-Voltage Electron Microscope- (HVEM-) Tandem Facility—have been designated official U.S. Department of Energy National User Facilities.

The APS, which opened in 1996, is a 7-gigaelectron volt (GeV) synchrotron particle accelerator that is designed to produce brilliant (highly collimated) and intense beams of high-energy Xrays. Another facility, ATLAS, -ray synchrotron radiation for advanced X-ray imaging and diffraction studies. Using the APS, scientists have performed X-ray diffraction analyses to unravel the structures of complex biological supramolecular assemblies, including ribosomes, enzyme-inhibitor (drug) complexes, and bacterial toxins.

ATLAS is a superconducting linear accelerator that uses accelerates beams of heavy ions up to and including uranium for high-energy nuclear physics research. The Intense Pulsed Neutron Source One example of this work involves experiments to probe the details of nuclear structure in order to answer fundamental questions concerning nuclear stability. The IPNS provides a powerful source of neutrons for structural studies.neutron-scattering experiments in materials science research; applications include high-temperature ceramics and advanced superconducting materials. The HVEM-Tandem Facility combines electron microscopy with ion-beam irradiation to study, for example, high-temperature superconductors.