Stephen Ginsberg, Ph.D.

Faculty Directory

Dr. Ginsberg is a Research Scientist in NKI's Center for Dementia Research (CDR) and a tenured Associate Professor in the Departments of Psychiatry, Physiology and Neuroscience, New York University Langone Medical Center (NYULMC). His research interests include understanding molecular and cellular underpinnings of selective vulnerability within specific sets of forebrain neurons, particularly as they pertain to neurodegenerative, neuropsychiatric, and neurodevelopmental disorders. Dr. Ginsberg employ animal and cellular models of neurodegeneration and neurodevelopment, as well as human postmortem brain tissues for functional genomic and proteomic based studies relevant to understanding the pathobiology of aging, mild cognitive impairment (MCI), and Alzheimer’s disease (AD). The underlying hypothesis of his research is that individual cell types are likely to have unique patterns of gene and protein expression under normative conditions that are altered in pathological states, which drives subsequent neurodegeneration.

Dr. Ginsberg is trained in neuroanatomy, neuropathology, neurochemistry, and molecular and cellular neurobiology, including single-cell RNA amplification. He has been studying gene and protein expression profiles in the forebrain including the hippocampal formation, basal forebrain, and neocortex for over 21 years. He has over 20 years of experience with RNA amplification and microarray technology, and over 14 years of experience in proteomic profiling in animal and cellular models and human postmortem brains.