TransZen-Wholesale-SPECIAL

This all-natural mood-enhancing formula is designed to promote optimal brain health and resilience, supporting a calm, relaxed and elevated mood. It can also be used as an effective meditation aid in various practices such as yoga, qi gong and sensory deprivation float tanks. Choosing scientifically validated ingredients, this formula applies concepts of cutting edge neuroscience to deliver a multifaceted approach to maintaining a healthy, happy brain

Made up of vitamins, minerals, amino acids, and herbs, TranZen was consciously crafted to help you transcend above your low mood, or difficulties reaching a relaxed, elevated state. We spent over 3 years researching and developing this formula to create the perfect balance of healing nutritional tools to promote that optimally Zen state we all want to achieve.

Description

A Happy Mind Starts With a Healthy Brain.

Happiness and peace is a complex intertwining of our chemical, emotional and spiritual states. When you have at least one of them in balance, the others come much easier. That’s why we are here to help you take care of the chemical part. Often times low moods can originate simple by a lack of sufficient nutrients and raw materials to repair and maintain a healthy, functioning brain. Just as our ankle hurts when it is injured, our brain can synthesize sadness when it is unhealthy too. Our formulas are designed by applying cutting edge neuroscience research concepts and creating a holistic, nutrition-based approach to maintaining a resilient and thriving brain. After immersing ourselves in the world of neuroscience and nutrition, we have found these concepts to be key in creating balance in the nervous system and thus, in our lives.

Filling in Nutritional Gaps- Providing the body and brain with nutrients that are fundamental for biochemical processes is vital for optimal wellness. Just as you need bricks to build a brick wall, you need the raw materials to build and maintain your brain tissue. In addition to correcting deficiencies, this includes providing precursors materials and enzymatic cofactors for the body to build neurotransmitters, proteins and neuronal structures such as dendrites, synapses and fatty cell membranes.

Combating Oxidative Stress- Though it is a natural part of life, excessive oxidative stress is essentially what damages our cells (neurons and all). Many plant-based antioxidant compounds in our formulas have been observed to stimulate the Nrf2 pathway, activating genes and promoting the body’s own production of endogenous antioxidant molecules such as glutathione. Activating this pathway by consuming polyphenol rich foods and supplements helps your body combat oxidative stress by neutralizing the free radicals with your body’s supply of antioxidants.

Healthy Inflammatory Response– Oxidative stress goes hand in hand with inflammation, another driving force of damaging cells and tissue. By promoting a healthy balance of free radicals vs. antioxidant molecules and directly influencing inflammation regulatory genes, our formulas are designed to promote a healthy inflammatory response in the brain and body.

Promoting Neurogenesis- Many studies show a trend that loss of neurons are associated with cognitive decline, mood disorders and a number of neurodegenerative diseases such as Parkinsons and Alzheimers. Neurogenesis is the growth of new neurons, dendrites and synpases. A growth factor called BDNF (brain derived neurotrophic factor) plays a big role in facilitating the repair, maintenance and growth of new neural networks. Many things can stimulate BDNF and promote neurogenesis such as certain foods/plants, exercise, meditation, fasting and more. Scientists agree that promotion of neuronal growth is an important marker of brain and mood health

Ingredients

Learn about all the amazing ingredients we chose to add to TransZen. Click on “ingredient Information” or “Scientific References” to open.

B Vitamins (B3, B6, B9 & B12)

The B vitamins are fundamental for whole body health. They are involved in a number of basic cell repair processes, detoxification pathways, and production of neurotransmitters. B6 is especially important for brain health because of it’s co-factor role in converting a number of molecules to their respective neurotransmitters (serotonin, GABA, dopamine, norepinephrine, and epinephrin). B12, also known as cobalamin, is a vitamin that is important in metabolism, DNA synthesis and regulation, and overall energy production. High B12 levels have shown to have neuroptrotective affects against brain atrophy associated with Alzheimers. Vitamin B12 deficiencies can cause symptoms such as fatigue, depression, poor memory and even cause symptoms of mania and psychosis. Folic acid, also known as B9, is fundamental for numerous processes in the body. It cannot be synthesized by the body so adequate intake through food is essential. Folic acid is needed for cell reproduction and synthesis, repair and methylation of DNA. There is a complex relationship between B12, folic acid and Iron. If proper ratios of the 3 aren’t maintained, one can mask a deficiency in another. Niacin (B3) and Riboflavin (B2) are also important B vitamins. Deficiencies in any of the B vitamins can result in fatigue, cognitive impairment and a number of mood disorders and mental illness symptoms.

We use methylated forms of B vitamins that are found in nature, NOT synthetic forms that the body has to convert into methylated forms to use.

Magnesium

Magnesium is essential to whole body health being critically involved in over 300 functions! It is especially important for brain health. Magnesium has been shown to enhance cognitive abilities. Magnesium contributes to synaptic plasticity, allowing brain cells to recover from stress or trauma more easily, and form new synaptic connections. Magnesium is also a NMDA glutamate antagonist. Drugs with the same mechanism of action have shown dramatic promise for treating depression. Because of conventional farming methods and overuse of land, many foods that used to be rich in magnesium are now lacking. Many people have magnesium deficiencies as a result. Supplementing with magnesium contributes to overall health and is a fundamental mineral for the nervous system.

We use high quality Magnesium Citrate because it is more absorbable and bioavailable to the body.

5-HTP (5-hydroxy-tryptophan)

5-HTP (5-hydroxy-tryptophan) is a chemical intermediate between the amino acid tryptophan and one of it’s end products, serotonin. 5-HTP is more readily converted into serotonin because it is not allocated to other cellular functions as much as tryptophan is, making it more available to be converted directly. It is also able to cross the blood-brain barrier easily, allowing it quick access to the brain where it is transformed into serotonin. Studies have confirmed that 5-HTP ingestion raises serotonin levels, and has efficacy as a treatment for depression/anxiety. Healthy serotonin levels promote calmness, feelings of peace and relaxation. Ideal serotonin levels help modulate sleep, appetite, inflammation, immune response and other neurotransmitter systems.

Mucuna pruriens

Mucuna pruriens, also called the velvet bean, is a legume native to Africa and Asia. It contains a rich amount of an amino acid called L-DOPA which is converted in the body to dopamine and later norepinephrine. It also contains trace amounts of serotonin, 5-HTP and nicotine, but at very low levels. Mucuna pruriens has been scientifically studied and found to improve a variety of conditions such as infertility, depression, parkinsons disease, ALS, snake bites and male virility. It shows antioxidant and neuroprotective properties as well as an ability to chelate heavy metals out of the body.

L-Theanine

L-theanine is a naturally occurring amino acid, mostly found in green and black tea plants. It has been found to be useful in improving mood, promoting calmness, reducing feelings of anxiety, and enhancing concentration. Unlike other calming agents, L-theanine does not cause drowsiness. Naturally occurring in caffeinated teas, it is known to “take the edge off” of stimulants such as caffeine, balancing out the excitable effects. It is an analogue of the excitatory neurotransmitter, glutamate. L-theanine can block or activate certain glutamate receptors in the brain, possibly preventing damaging effects from excessive glutamate excitation of neurons. This may be a mechanism for it’s neuroprotective properties. It also increases levels of Serotonin, dopamine and GABA in the brain. It also has been found to increase levels of BDNF (Brain derived neurotrophic facter) promoting growth and repair of dendrites and synapses in brain cells, as well as forming new neurons.

Turmeric

Turmeric (Curcuma longa) is a spice that’s been used in Ayurvedic medicine and food for thousands of years in Asian countries. It contains a group of polyphenolic compounds called curcuminoids. The most researched of these compounds is curcumin. Turmeric has been found to exhibit anti-cancerous, antifungal, antibacterial, anti-inflammatory, neuroprotective and antioxidant properties. We chose turmeric as one of our ingredients because of it’s affect on inflammatory response, antioxidant production in the body, and ability to promote neurogenesis. Stress, sleep deprivation, and toxins can cause oxidative stress and tissue damage to our body and brains. Turmeric promotes a healthy inflammatory response and helps the body recover to optimal function. Turmeric increases levels of antioxidant vitamins in the body such as vitamin C and E, and is a strong stimulator of the Nrf2 pathway that promotes endogenous antioxidant production, combating oxidative damage to cells and DNA Turmeric also promotes a protein called BDNF, which regulates brain cell and dendrite growth. Turmeric has been clinically shown to increase BDNF in hippocampal regions of the brain.

Spirulina

Spirulina is blue-green algae, composed of two species of Arthrospira. It is considered a complete protein, meaning it contains all 9 of the essential amino acids. This includes L-tryptophan, which can be converted into serotonin, and also L-phenylalanine and L-tyrosine, which can be converted into dopamine. It also contains the omega-3 fatty acid, alpha linolenic acid, which has neuroprotective effects, can aid in managing depression, and contributes to overall brain health. Spirulina contains a number of vitamins and minerals, with especially high amounts of B vitamins and iron. Spirulina is also useful for preventing oxidative damage, promoting stem cell genesis, and preventing memory loss.

Blueberry

The fruit of the blueberry plant (Vaccinium) contains a number of powerful antioxidants and phytochemicals which have many health benefits. Blueberries contain anthocyanins which evidence has shows reduces inflammation, may help fight cancer, reverse aging, and improve memory and depression symptoms. Blueberry compounds, like turmeric, also contribute to neurotrophic cell proliferation by activating BDNF and promoting neurogensis in the hippocampal region of the brain. They also provide protection against neurotoxicity and DNA damage. Also like Turmeric, blueberry compounds stimulate the bodies antioxidant production by interacting with regulatory genes helping your body combat oxidative stress. Blueberry also interacts with inflammation regulating genes and has been clinically shown to prevent cognitive decline and memory loss.

Ashwagandha

Ashwagandha (Withania somnifera) has been traditional used as an ayurvedic herb for over 4,000 in ayurvedic medicine. It is considered an adaptogen because of it’s remarkable ability to assist in maintaining homeostasis in the body during stress or changes in environment. It has neuroprotective and hormone balancing properties and also promotes resilience and recovery from stress. It contains compounds called withanolides that have shown to increase neurotransmitter activity, improve protein synthesis, boost antioxidant activity and promote a healthy inflammatory response. Ashwaganda also protects against glutamate-mediated excitotoxicity which can cause damage to neurons and dysregulation of other neurotransmitter systems.

Passion Flower

Passionflower (Passiflora incarnate) has been used traditionally to treat anxiety and insomnia .Studies show that Passiflora extracts not only contain a high amount of GABA, but are also able to induce direct GABA currents via activation of GABA receptors in the hippocampus. GABA has a calming effect on the nervous system and is the category of receptors that many anti-anxiety medications target. Most species of passion flower also contain beta-carboline harmala alkaloids as well as. Some of these have MAOI activity, mildly increasing levels of certain neurotransmitters. Passion flower extracts also show potential in aiding in the treatment of addictive drug withdrawals (opiates, nicotine etc.) Studies of people with generalized anxiety disorder show that passionflower is as effective as the drug oxazepam (Serax) for treating symptoms.

Lemon Balm

Lemon balm (Melissa officinalis) has been used historically for over 2,000 years to improve disorder of the brain and nervous system. Research suggests that lemon balm can improve mood and cognitive performance as well reduce symptoms of insomnia, anxiety and the harmful effects of stress. Like passion flower, Lemon balm is suspected to produce an anxiolytic (anti-anxiety) and calming effects by increasing GABA activity in the brain. Speculations suggest that it may inhibit an enzyme that breaks down GABA, resulting in elevated levels. Some strains have also shown cholinergic activity, likely contributing to improvements in memory and cognitive effects.

Zinc

Zinc is a crucial mineral for overall health, but it is especially important for brain and mood health. Zinc plays a key role in hundreds of enzymatic reactions in the body including the production of neurotransmitters and hormones. It is required in the synthesis of dopamine, as well as testosterone and important to regulating estrogen and progesterone levels in woman. Zinc has also been identified as helping control insulin sensitivity. It helps maintain homeostasis in brain cells and can also acts as an antioxidant, making it neuroprotective. Zinc has been found to protect against inflammation and neurodegenerative diseases such as Alzheimers. Many people with depression, anxiety, ADHD or other brain disorders have a zinc deficiency. Zinc has been found to actually reduce the amount of pro-inflammatory cytokines and markers such as C-reactive protein that are circulating in the body. It also acts as a chelator for heavy metals and helps balance healthy metal levels in the body. Stress often depletes Zinc levels in the body.

We use zinc in the form of Zinc Picolinate for it’s high bioavailability and easiness for the body to assimilate.

Black Pepper

Black pepper, from the plant Piper nigrum, contains a polyphenolic compound called Piperine. Piperine has been clinically shown to improve the absorption of nutrients when taken with food or other supplements. It is also a strong antioxidant and anti-inflammatory compound. Piperine has also been found to be an effective pain reducing agent. Black pepper also aids in digestion and detoxification. Piperine can inhibit certain enzymes that break down compounds in the body, resulting in elevated levels of neurotransmitters and better absorption of circulating nutrients, phytochemicals or drugs from the blood stream.