The 110gr VMAX or TTSX are light years more effective than the subsonics. My personal take is that if I am shooting at an intruder in my house, stopping the threat as fast as possible is my primary goal.

Also, both the subsonics and TTSX will penetrate a lot of ballistics gel, so I think you are right to be concerned about penetration. I think the combination of more demanding shot placement and a lot of penetration make the subsonics less desirable for home defense though.

Heavy subsonic essentially = pistol like wounds, with WAY more penetration. You're going to be poking .30 caliber holes and not much more.
Light supersonic bullets will essentially give you the power of a 30-30 or 7.62x39 with expanding projectiles. Generally an impact velocity over 2000fps is needed to cause hydrostatic shock, which can destroy or damage organs that aren't directly in the path of the bullet, which a subsonic bullet just wont do, even with more impact energy than a standard pistol caliber. That energy essentially turns into penetration. If the subsonic bullet is able to expand, it'll simply make a bigger nastier hole but still wont perform like an expanding bullet at 2000+fps.
The only downside to the supersonic bullet is the sonic crack, which isn't terrible, compared to the initial blast of an unsuppressed rifle. Suppressed guns with supersonic bullets still can be surprisingly quiet, and it's going to be a lot quieter than an AR in .223 unsuppressed.

I agree 100% with JD0x0. Using an SDN-6 on both, a supersonic 300 Blackout out of a 9" barrel is quieter than a 5.56 out of a 16" barrel. Inside it's loud enough that it's not comfortable, but it's not so loud that it's going to hurt your ears too much.

I also would really worry about over-penetration with subs; pistol rounds already over-penetrate through interior walls, and I'd worry that the 300 Blackout subs would penetrate even more due to their shape. I recommend using 110 or 115 gr. supers for HD and save the subs for just having fun.

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