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In 2266, the ship transferred a young man, Charles Evans, who had been stranded on the planetThasus for seventeen years, to the USS Enterprise, so that he could be transported to Colony Alpha 5, where he would be reunited with his closest living relatives. While Charlie was on board the Antares, however, Ramart and his crew discovered that he had incredible psychokinetic powers, and could force the crew to do whatever he wanted.

After transferring Charlie to the Enterprise, Captain Ramart attempted to signal them to warn them of the danger that Charlie posed, but Charlie used his powers to remove a warped baffle plate from the Antares' energy pile, causing a warp core breach which destroyed the ship with all hands lost. (TOS: "Charlie X")