Homocysteine and Heart Disease

What Is Homocysteine?

Homocysteine is an amino acid formed in the body from another amino acid called methionine. Certain B vitamins are needed to breakdown these amino acids. The vitamins include
vitamin B6,
vitamin B12, and
folate. A deficiency of any one of these vitamins, most particularly folate, can lead to an elevation in blood levels of homocysteine.

Does Homocysteine Increase the Risk of Heart Attack?

Levels of homocysteine increase with age, and elevation is more common in men and postmenopausal women. Although some studies have found an association with high homocysteine levels and heart disease, whether or not homocysteine is a risk factor for heart disease remains controversial.

During the last 2 decades, a connection between mild to moderate elevations of homocysteine and heart disease has shown up in some, but not all studies. Organizations like the American Heart Association (AHA) do not currently identify high homocysteine levels as a major risk factor for cardiovascular disease.

If you have not yet been tested, do not be surprised if your doctor is somewhat reluctant to measure your homocysteine level. If other risk factors for heart disease are already present, knowing that your homocysteine level is elevated may not change your treatment. However, according to the AHA, getting screened for homocysteine levels may be useful if you have a personal or family history of cardiovascular disease and do not have the common risk factors, like smoking, high blood pressure, high cholesterol.

What If You Have Elevated Homocysteine Levels?

Homocysteine levels are reduced when intake of folate, vitamin B6, and vitamin B12 is increased. However, studies have not shown that taking these vitamins can prevent or treat cardiovascular disease.

The AHA suggests that people at high risk should make sure they are getting enough folate, vitamin B6, and B12 in their diet. Your doctor can give you specific recommendations about the appropriate dosages for you. Here are the general recommendations for daily intake of folate, vitamin B6, and B12:

This content is reviewed regularly and is updated when new and relevant evidence is made available. This information is neither intended nor implied to be a substitute for professional medical advice. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with questions regarding a medical condition.