The full transcendence of one's consciousness into another dimension through the medium of certain psychedelic drugs. These psychedelic breakthroughs are achieved mainly through very high doses of DMT, salvia divinorum, amanita muscaria mushrooms, ibogaine, or psilocybin.

After I took three very large inhalations of DMT I experienced a breakthrough into the sacred realm known as Hyperspace.

To smoke enough DMT for a very immersive and intense trip, usually lasts around 15 minutes and in which almost all connection to the real world is lost. Many who have broken through describe it as a life changing experience, but other than that the trip is indescribable.

Yo man I got some DMT u wanna break through tonight?
Nah man I did last night, that was some freaky shit.