The new skype 2.1 beta
(woohoo - Linux users are now only 2.0 versions behind Windows, way to go Skype!)
doesn't come with a CentOS rpm, unlike earlier versions. And the Fedora packages
that are available are for FC9 and FC10, which are too recent to work on a stock
RHEL/CentOS 5 system.

So here's how I got skype working nicely on CentOS 5.3, using the static binary
tarball.

Note that while it appears skype has finally been ported to 64-bit architectures, the
only current 64-bit builds are for Ubuntu 8.10+, so installing on a 64-bit CentOS
box requires 32-bit libraries to be installed (sigh). Otherwise you get the error:
skype: /lib/ld-linux.so.2: bad ELF interpreter: No such file or directory.

Tangentially, if you have any video problems with your webcam, you might want to check out
the updated video drivers available in the
kmod-video4linux package from the shiny new
ELRepo.org. I'm using their updated uvcvideo module with a Logitech
QuickCam Pro 9000 and Genius Slim 1322AF, and both are working well.