Dr. Caine joined the faculty of the University of Rochester in 1978, following medical school at Harvard, residency training at the Massachusetts Mental Health Center and National Institute of Mental Health, and further postdoctoral research at NIMH. He says he became fascinated with the relationships between organized brain functioning and behavioral disorders. In addition to his residency, he pursued additional training in neuropsychology and neurology as a means of exploring neuropsychiatry.

Dr. Caine's early research dealt with Huntington's disease, Tourette's syndrome and, to a lesser extent, Alzheimer's disease. This led to studies of depression and to the interface between mood disorders and general medical conditions. Since the late-1980s Dr. Caine, together with colleagues in what now has become the University of Rochester Center for the Study and Prevention of Suicide, has carried out research to understand the risk factors that lead to suicide, and has worked collaboratively with investigators in the U.S. and internationally to develop new public health and therapeutic approaches for suicide prevention.

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