Improved outcome of renal transplant as a result of better HLA matching is offset by prolonged cold ischemia times, a finding that adds to the debate over the utility of national sharing of donor kidneys.

Indivumed's current tumor biobank of over 6000 patient-cases, collected with a mean cold ischemia time of less than eight minutes, serves as a resource for Indivumed's cancer research in primary cells and biomarkers as well as for the use of pharmaceutical and biopharma partners.

Because of increasing recognition of the importance of cold ischemia time, particularly for organs of marginal quality, the UNOS Liver and Intestinal Organ Transplantation Committee and Pediatric Transplantation Committee anticipate that the size of the distribution unit would be limited to minimize cold ischemia time while providing a median waiting time less than the expected median survival time for any level of disease severity.

A multivariate analysis combining both groups of patients showed that significant risk factors for death were preoperative hospitalization, longer cold ischemia times of the donor liver, a liver disease etiology of hepatitis C virus infection, and alcohol consumption.

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