Role of the Interaction between Cation-Chloride cotransporters and EGF and PDGF in Migration of Brain Tumor Stem Cells106743Maryland Stem Cell Research Fund (TEDCO)P.I.: Tomas Garzon-MuvdiRole on Project: Mentor

Medical School Research FellowshipCornell UniversityQuiñones-Hinojosa (PI) 100%Goal was to study the differences in suicide patterns between women and men in New York City

1993 – 1994

Honor’s Research Scholar (UC Berkeley)Ford Baccalaureate Fellowship Quiñones-Hinojosa (PI)20 %Goal was to study long term potentiation and synaptic plasticity in the nucleus accumbens responsible for addictive behavior

Summer 1994

Health Professional Research Fellowship in NeurobiologyT32 NS07112-15S1NIH- NINDSDavid Potter (PI)100%Goal was to learn molecular biology and clone the ecdysone receptor gene responsible for aggressive behavior in the American lobster Homarus Americanus

09/1994 – 12/1996

Research Training Grant Fellowship in NeurobiologyPO1 NS025915NIHEdward Kravitz (PI)20%Goal was to learn molecular biology and clone the ecdysone receptor gene responsible for aggressive behavior in the American lobster Homarus Americanus

07/1997 – 06/1999

Medical Student FellowshipHoward Hughes Medical InstituteQuiñones-Hinojosa (PI)100%Goal was to study the role of neruoprotective agents on neuronal ischemia

12/1998 – 06/1999

Squibb Fellowship in Academic MedicineBristol-Myers- Massachusetts General Hospital Department of Neurosurgery and Harvard Medical SchoolQuiñones-Hinojosa (PI)100%Goal was to study the effect of hypothermia in neuronal activity

07/2003 – 07/2004

Ruth L. Kirschstein Individual National Research Service AwardNIH 1 F32 NS 47011-01NIH- NINDSQuiñones-Hinojosa (PI)100 %Goal was to study human neural stem cells and the cytoarchitecture of the human subventricular zone

01/2006 – 1/2007

Johns Hopkins University Passano Physician Scientist AwardHopkins MedicineQuiñones-Hinojosa (PI)100 %Migration of Human Neural Stem Cells In Vitro and In Vivo. The major goal of this project is to elucidate the subventricular zone (SVZ) cytoarchitecture of patients with brain cancer and to study the role of EGF in the migratory ability of stem cells derived from the human SVZ in these patients.

Association of American Medical Colleges-Nickens FellowshipAAMC NickensQuinones-Hinojosa (PI)1%Migration of Human Neural Stem Cells In Vitro and In VivoThe major goal of this project is to address basic questions about the human brain, the cytoarchitecture, the precise location of stem cells, and molecular factors that regulate stem cell biology within the normal brain and in brain tumors

7/2007-6/2008

Howard Hughes Medical Institute HHMIQuinones-Hinojosa (Mentor) 100%The Role of EGF in the Migration of Human Neural Stem Cells and Brain Tumor Stem Cells In Vitro and In Vivo The primary goal of this study is to ascertain whether epidermal growth factor (EGF) stimulation can induce adult human neural stem cells (hNSCs) to migrate in a manner similar to that seen in glioblastoma multiforme (GBM) astrocytes. It is our hypothesis that hNSCs will transform into a more aggressive phenotype and migrate in a manner similar to that of BTSCs

7/2007-7/2008

American Association of Neurological SurgeonsAANSQuinones-Hinojosa (Mentor)100%The Role of PDGF and EGF in the Migratory Pattern of Brain Cancer Stem Cells and Comparison to Normal Fetal and Adult Human Stem Cells The major goal of this project is to study stem cells in the human brain and consequently the effect that effect PDGF and EGF have on the migratory behavior of these stem cells. We will test the hypothesis that human adult stem cells have the ability to migrate and that their manipulation with PDGF and EGF can change them to a more aggressive migratory behavior that resembles that of high-grade tumors and/or the fetal human utilizing both in vitro and in vivo studies.

American Society of Clinical Oncology (ASCO) Foundation AwardASCOQuinones-Hinojosa (P.I.)Migration of Human Neural Stem Cells In Vitro and In VivoThe major goal of this project is to prospectively collect clinical data from patients with brain cancer (with authorization from patients and with approval from the University), to correlate the findings of cancer stem cells migratory ability to the final pathology and clinical outcome of patients.Overlap: there is no budget overlap between this grant and the NIH KO8 grant. There is intellectual, scientific, and effort overlaps to the NIH KO8 grant.

7/1/06-6/30/08

American College of Surgeons Franklin Martin Faculty Research AwardACSQuinones-Hinojosa (P.I.)Migration of Human Neural Stem Cells In Vitro and In VivoThe major goal of this project is to address basic questions about the human brain, the cytoarchitecture, the precise location of stem cells, and molecular factors that regulate stem cell biology within the normal brain and in brain tumors.Overlap: there is no budget overlap between this grant and the NIH KO8 grant. There is intellectual, scientific, and effort overlaps to the NIH KO8 grant.

7/1/06-6/30/09

Children’s Cancer FoundationCCFQuinones-Hinojosa (P.I.)Isolation, Characterization, Migration, and Transformation to Cancer Stem Cells of Human Pediatric Subventricular Zone Neural Stem CellsThe major goal of this project is to study the pediatric human brain and to isolate pediatric human neural stem cells as well as cancer stem cells and to characterize their migratory ability in addition to studying the ability of these neural stem cells to transform to cancer stem cells in the pediatric population.Overlap: there is no budget overlap between this grant and the NIH KO8 grant. There is very little intellectual, scientific, and effort overlaps to the NIH KO8 grant

4/1/06-3/31/09

Brain Tumor Founder CollaborativeBTFCQuinones-Hinojosa (Co-P.I.)Tumor Stem Cell-Based Drug Discovery for Adult and Pediatric GliomaThe major goal of this project is to perform hypothesis-driven and unbiased high through-put in vitro drug screens to identify agents with activity against a unique panel of adult and pediatric glioma stem cell lines.Overlap: there is no budget overlap to NIH KO8 grant. There is minimal intellectual, scientific, and effort overlaps to NIH K08 grant.