These results identify USP4 as a novel regulator of Dvl in Wnt/beta-catenin signal and show its involvement in Wnt3a-induced osteoblast differentiation

Authors conclude that the planar cell polarity (PCP) pathway contributes significantly to the motility and hence the invasiveness of glioblastoma multiforme (GBM) cells, and that Nrdp1 acts as a negative regulator of PCP signaling by inhibiting Dvl through a novel polyubiquitination mechanism.

The DEP domain of Dishevelled undergoes a conformational switch, from monomeric to swapped dimer, to trigger DIX domain-dependent polymerization and signaling to beta-catenin.

two mutually exclusive functions of the DEP domain in Wnt signal transduction - binding to Frizzled to recruit Dishevelled to the receptor complex, is reported.

we show that Wnt5a rapidly represses rDNA gene transcription in breast cancer cells and generates a chromatin state with reduced transcription of rDNA by RNA polymerase I (Pol I). These effects were specifically dependent on Dishevelled1 (DVL1), which accumulates in nucleolar organizer regions (NORs) and binds to rDNA regions of the chromosome.

Mutations in DVL1 cause an osteosclerotic form of Robinow syndrome, with the osteosclerosis possibly the result of an interaction between the wild-type and mutant alleles, leading to elevated canonical Wnt signaling.

Data show that the peptide binding pocket of the Dishevelled 1 (Dvl1) PDZ domain is stabilized upon CXXC finger 5 protein (CXXC5) binding.

Here we show that the peptide-binding pocket of the Dvl PDZ domain can be occupied by Dvl's own highly conserved C-terminus, inducing a closed conformation.

The interaction of Dvl1 with Syt-1, which is regulated by Wnts, modulates neurotransmitter release.

High disheveled expression is associated with pulmonary fibrosis.

findings indicate that Dvl-1 may be an underlying participant of oxidative stress induced by selenium deficiency

These results support a novel cell-autonomous postsynaptic role for Dact1, in cooperation with Dishevelled-1 and possibly Disrupted in Schizophrenia-1, in the formation of synapses on cortical interneuron dendrites.

we show that Dvl-1 expression is restricted to OSNs in the dorsal recess of the nasal cavity, and labels a unique subpopulation of glomeruli. Dvl-2 and Dvl-3 have a widespread distribution in both the olfactory epithelium and olfactory bulb .

Fuzzy appears to control subcellular localization of the core PCP protein Dishevelled, recruiting it to Rab8-positive vesicles and to the basal body and cilium. We show that loss of Fuzzy results in inhibition of PCP signaling

The antagonistic functions of Vangl2 and Dvl1 allow sharpening of planar cell polarity signaling locally on the tips of the filopodia to sense directional cues, Wnts, eventually causing turning of growth cones.

p114-RhoGEF and Lfc are critically involved in Wnt-3a- and Dvl-induced RhoA activation and neurite retraction in N1E-115 cells.

TMEM88 associates with Dvl proteins and regulates Wnt signaling in a context-dependent manner

phosphorylation of Dvl triggers negative feedback regulation for different branches of Wnt signaling in a Ror2-dependent manner.

Loss of CYLD instigates tumor growth in human cylindromatosis through a mechanism in which hyperubiquitination of polymerized Dvl drives enhancement of Wnt3/beta-catenin responses.

preliminary characterization of it's interaction with Smad3

Data show that Dishevelled (Dvl) binding peptides of Frizzled inhibited canonical Wnt signaling and blocked Wnt-induced secondary axis formation in a dose-dependent manner, but did not block noncanonical Wnt signaling.

The specificity of observed social interaction deficits suggests that lack of Dvl1 is associated with deficits in the recognition of social hierarchy and dominance. The sensorimotor gating deficit was subject to environmental influences.

Results suggest that casein kinase Iepsilon functions as a molecular switch to direct Dishevelled (Dvl) from the c-Jun N-terminal kinase pathway to the beta-catenin pathway, possibly by altering the conformation of the C terminus of Dvl.

DEP domain is responsible for the membrane translocation of Dvl-1 protein upon Wnt signal stimulation.

Different Dvl proteins (Dvl1, Dvl2, Dvl3) and the composition of dishevelled-beta-arrestin protein complexes contribute to the specific activation of individual branches of Wnt signaling in Xenopus gastrulation.

DVL1 Protein Überblick

Protein Überblick

DVL1, the human homolog of the Drosophila dishevelled gene (dsh) encodes a cytoplasmic phosphoprotein that regulates cell proliferation, acting as a transducer molecule for developmental processes, including segmentation and neuroblast specification. DVL1 is a candidate gene for neuroblastomatous transformation. The Schwartz-Jampel syndrome and Charcot-Marie-Tooth disease type 2A have been mapped to the same region as DVL1. The phenotypes of these diseases may be consistent with defects which might be expected from aberrant expression of a DVL gene during development.