To the Editor: The association between use of medications in older people and poor mental health has been investigated in a limited number of studies, and results have been contradictory.[1, 2] Given possible associations between medications and mental health,[3, 4] there is potential for multiple medication use to contribute to age-associated declines in mental health,[5] but the evidence concerning the association between mental health and medication use is scarce. The aim of this study was to examine the association between medication use and mental health in older women (aged 76–81) from the Australian Longitudinal Study on Women Health (ALSWH).