RT Journal Article
SR Electronic(1)
A1 Pearlman, Eliot J.
A1 Lampe, Richard M.
A1 Thiemanun, Withoon
A1 Kennedy, Robert S.
YR 1977
T1 Chemosuppressive Field Trials in Thailand
JF The American Journal of Tropical Medicine and Hygiene,
VO 26
IS 6
SP 1108
OP 1115
DO https://doi.org/10.4269/ajtmh.1977.26.1108
PB The American Society of Tropical Medicine and Hygiene,
SN 0002-9637,
AB Abstract
A chemosuppressive field trial in an area of Thailand with known chloroquineresistant falciparum malaria was undertaken to test the efficacy of the preparation sulfadoxine (S)-pyrimethamine (Py) in suppressing falciparum and vivax parasitemias. Seven hundred and forty-seven Thai villagers were randomly assigned to one of five study groups: sulfadoxine (1,000 mg)-pyrimethamine (50 mg) every 2 weeks [S-Py (high dose)]; sulfadoxine (500 mg)-pyrimethamine (25 mg) every 2 weeks [S-Py (low dose)]; diformyldapsone (400 mg)-pyrimethamine (25 mg) weekly [DFD-Py (high dose)]; diformyldapsone (200 mg)-pyrimethamine (12.5 mg) weekly [DFD-Py (low dose)]; and placebo. Six hundred and eight-eight study subjects (92%) completed the 26-week trial. Sulfadoxine (1,000 mg)-pyrimethamine (50 mg) given every 2 weeks was shown to be an effective chemosuppressive against both falciparum and vivax parasitemias, causing an eight-fold reduction in falciparum parasitemias, and an approximately three-fold reduction in vivax parasitemias. While the low dose S-Py group and the two DFD-Py groups were less effective than the high dose S-Py group in suppressing falciparum parasitemias, the high dose DFD-Py combination was as effective as the high dose S-Py combination in suppressing vivax parasitemias. There was no evidence of drug reactions. A discernible decrease in the leukocyte count was noted over a 6-month period in the high dose S-Py group.,
UL http://www.ajtmh.org/content/journals/10.4269/ajtmh.1977.26.1108