Zeuxis, a 5th-century BC Greek painter, is said to have died laughing at the humorous way he painted the goddess Aphrodite – after the old woman who commissioned it insisted on modeling for the portrait.[8]

One ancient account of the death of Chrysippus, the 3rd century BC GreekStoic philosopher, tells that he died of laughter after he saw a donkey eating his figs; he told a slave to give the donkey neat wine to drink with which to wash them down, and then, "...having laughed too much, he died" (Diogenes Laertius 7.185).[9]

In 2003, Damnoen Saen-um, a Thai ice cream salesman, is reported to have died while laughing in his sleep at the age of 52. His wife was unable to wake him, and he stopped breathing after two minutes of continuous laughter. He is believed to have died of either heart failure or asphyxiation.[15]

In the Batman franchise, famed villain The Joker often kills his victims using a poison that causes uncontrollable and quickly fatal fits of manic laughter – the victim's corpse is often left with a huge ghastly smile reminiscent of the Joker's own. In the 1989 film, a news broadcast reporting a scheme involving this very toxin (named "Smilex" in this film) is cut short when one of the reporters begins laughing hysterically, as if amused by the sinister plot, before collapsing dead with the characteristic rictus.

At the end of the film Mary Poppins, Mr. Dawes, Sr. (Dick Van Dyke) is said to have literally died laughing after being told a joke: "I know a man with a wooden leg named Smith." "Really? What's the name of his other leg?"

In Ice Age: Dawn of the Dinosaurs where the heroes cross the "Chasm of Death". The chasm is filled with gas fumes (a mixture of helium and laughing gas, causing anyone who breathes in it to laugh uncontrollably while speaking in a high-pitched voice). Although the gas is not the actual cause of death, victims usually cannot stop laughing and thus die while trying to cross the chasm.