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SF5-containing building blocks

The organic chemistry of the pentafluorosulfanyl group (SF5) has been known since 1950’s. As the SF5-group is larger and more lipophilic than the CF3-one, it is often considered as a “super-trifluoromethyl group." Over the past decade, the SF5–containing organic compounds already found great practical application in argochemistry and medicinal chemistry.