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AM-2201

AM-2201 is a highly potent synthetic cannabinoid that binds CB1 and CB2 receptors and produces effects consistent with naturally occuring cannabinoids such as THC. It is closely related in structure to the better characterized cannabinoid JWH-018, though AM-2201 is reported to be several times more potent with active doses beginning in the sub-milligram range. It is known among users of synthetic cannabinoids for its unusual potency and steep dose-response curve, creating an especially high risk of overdose for naive and even experienced users. It is typically laced onto a smoking substrate then smoked or vaporized. AM-2201 has been identified in some batches of herbal smoking blend products such as K2 and other "Spice" like products.

The onset can be disturbingly rapid for some, and peaceful and evenly paced for others.

Some report that the vapor is comfortable to smoke, whereas many others report that it is harsh or extremely harsh and painful.

Some users report that when vaporized, the AM-2201 turns into a red liquid, others that it turns transparent, others that it turns first yellow and then orange. Others report no liquid, only evaporation. It is suggested this could be due to the amount of heat used.

Someone posted within another forum that AM-2201 dissolves easily within slightly warmed Everclear. They mixed 2.5mg of AM-2201 per ml of Everclear and advised that a comfortable entry dose is 5mg / 2ml. I also read that 7.5 / 3ml was a strong but easily manageable dose and that a 10mg / 4ml dose was very powerful and likely their personal "max". It was described as bordering on being "too much" for someone with no tolerance to AM-2201 and only a slight tolerance to JWH-018.

This post said that onset, contrary to other JWH compounds, is noticeably faster with the first detection at the 15 minute mark. The duration was listed at 2 hours on lower dose and a full 3 hours at higher dose.

Precise measurement and sensible / slow incremental dosing was listed as extremely important with AM-2201. They posted that oral intake of this compound was, by far, their preferred route of administration.

Many users report that the intensity of AM-2201 in high doses can be overwhelming. This may in part be due to the extreme potency, thereby making overdose a significant danger. AM-2201 seems to be very unforgiving in high doses compared to other cannabinoids. Extreme anxiety, breathing difficulties, vomiting, blackouts and convulsions have been reported. Some user reports have suggested it can cause uncomfortable distortions to reality and hallucinations so people with pre-existing mental health conditions could be at risk of exacerbating symptoms.

Proper scales capable of measuring the sub-milligram range are necessary to avoid this.

AM-2201 is reported to have a high abuse/addictive potential, with withdrawals.

While tolerance builds up fast, some report that it dissipates quickly as well. So, if you have built up a high tolerance to AM-2201 and take a short break, you must take care and start with a very low dosage.

The parent drug of AM-2201 is currently uncontrolled in the UK as haloalkyl substitution of the indole nitrogen is not explicitly listed as a derivative that contravenes the 2009 order on synthetic cannabinoids.

This is however more of a legal loophole/oversight rather than chemical wizardry on the part of the manufacturers. If the UK government forges ahead with its plan to weaken the role of the ACMD in legislative amendments then this loophole could be plugged at very short notice.

Some unfluorinated synthesis impurities might be class B controlled substances, so purity is potentially critical to ensure that this compound is legal to possess in the UK.[1]