The ESP Timeline (one of the site's most popular features) has been
completely updated to allow the user to select (using the timeline controls
above each column) different topics for
the left and right sides of the display.

First American patent issued in photography to Alexander Wolcott for his camera.

The first postage stamp, called the "Penny Black" and bearing the image of Queen Victoria, is issued in England.

The oil-immersion microscope is invented by Giovanni Battista Amici (1786-1863), a former professor of mathematics who is now the director of the observatory at the Royal Museum in Florence, and an astronomer to the Grand Duke of Tuscany. The objective lens of this microscope is immersed in a drop of oil which sits on top of the object under study; this helps to minimize aberrations caused by the light source.

Charles Darwin's book The Structure and Distribution of Coral Reefs being the first part of the geology of the voyage of the Beagle, is published. During the year Darwin composes an abstract of his theory of species evolution.

The term DINOSAUR is coined by Richard Owen (1804-1892) to describe a class of animals that we now believe were dominant on the Earth for approximately 175 million years.

Based on Agassiz's Ice Age theory, self-taught science enthusiast Charles MacLaren publishes a newspaper article explaining that substantial ice sheets in the northern hemisphere would have lowered global sea level.

German physician and physicist Julius Robert Mayer is the first to state the law of conservation of energy, noting specifically that heat and mechanical energy are two aspects of the same thing.

On the uniform motion of heat in homogeneous solid bodies, by William Thomson, aka Lord Kelvin (1824-1907), is published. Thomson's concern with the physics of cooling bodies will draw him into debates concerning the age of the Earth. In 1846 he calculates that the Earth can be no more than 100 million years old.

The change in the observed frequency of waves emitted from a source, moving relative to the observer, is described by Christian Johann Doppler (1803-1853). This phenomenon is now known as the Doppler Effect.

1842

(no entry for this year)

Louis Agassiz completes Les Poissons Fossiles describing fossil fish of the world. This single monograph increases tenfold the formally described vertebrates known to science.

That the nervous system uses electricity in communicating between different parts of the body is demonstrated by Emil Heinrich du Bois-Reymond (1818-1896). He founds the field of electrophysiology.

John Stuart Mill publishes Logic.

James Prescott Joule determines the mechanical equivalent of heat by measuring the rise in temperature produced in water by stirring it.

1843

Jerome Increase Case, a 24 year-old farmer from Oswego County, New York, introduces the J. I. Case Threshing Machine. The J. I. Case Company will manufacture farm equipment and will become the largest thresher producer in the world.

The first tunnel under the Thames opens on March 25, built by Isambard Kingdom Brunel (1806-1859). {a]The Thames Tunnel{/a} connects Rotherhithe and Wapping, London. Although it was a triumph of civil engineering, the Thames Tunnel was not a financial success. It had cost a fortune to build — £454,000 to dig and another £180,000 to fit out — far exceeding its initial cost estimates. Proposals to extend the entrance to accommodate wheeled vehicles failed owing to cost, and it was only used by pedestrians. It became a major tourist attraction, attracting about two million people a year, each paying a penny to pass through.

Charles Darwin first outlines his thoughts on natural selection in an unpublished essay.

The second part of the Geology of the Beagle, Charles Darwin's Geological Observations on Volcanic Islands Visited During the Voyage of H.M.S. Beagle, is published. Darwin's book claims to supply evidence for the geological theories of Charles Lyell (1797-1875), from areas that Lyell himself had never seen.

That all the cells in an organism are generated from successive divisions of the egg cell is described by Rudolf Albert von Kölliker (1817-1905). Kölliker shows that the egg is itself a cell.

1844

In Hartford, Connecticut, dentist Horace Wells (1815-1848) uses nitrous oxide as an anesthetic; he is the first to do so.

The School of Medicine in Paris creates a gallery of comparative anatomy.

Michael Faraday relates magnetism to light after finding the magnetic field effects the polarization of light in crystals. He proposes that light may be waves of electromagnetism. He also describes the phenomena of diamagnetism and paramagnetism, which he explains in terms of his concept of a magnetic field.

James Prescott Joule discovers that the length of an iron bar changes slightly when the bar is magnetized.

1846

Nitroglycerine is discovered by chemist Ascanio Sobrero (1811-1870), although he uses to term "pyroglycerine". Because of the risks involved in its production, it will not be manufactured commercially for more than a decade.

The lock-stitch sewing machine is patented by Elias Howe (1819-1867).

Jakob Mathias Schleiden and Theodor Schwann announce that cells are the basic units of all living structures.

In his Account of a New Anesthetic Agent, obstetrician Sir James Simpson (1811-1870) argues that chloroform, a substance he discovered, is a better anesthetic than nitrous oxide or ether. Simpson has begun to use chloroform as an anesthetic in childbirth.

Über die Erhaltung der Kraft ("On the Conservation of Force"), by Hermann Ludwig von Helmholtz (1821-1894), is published. It articulates what later becomes known as the Conservation of Energy.

1847

The rotary, or "lightning" printing press is patented by Richard March Hoe (1812-1886). It is used first by the Philadelphia Public Ledger.

On the archetype and homologies of the vertebrate skeleton, by Richard Owen (1804-1892), is published. In the book Owen argues that the skull, and other parts of the body, are formed by the modification of the vertebra of different animals.

A Neanderthal skull is excavated from Forbes Quarry on the northern side of the Rock of Gibraltar. Over the next few decades, the skull will be stashed in a library cabinet in Gibraltar, dusted off and sent to London, accurately likened to the ancient skullcap from Neander Valley in Germany, nearly named Homo calpicus, and finally stored and largely forgotten in the Royal College of Surgeons.

The American Medical Association is founded in Philadelphia, with a mission "to promote the science and art of medicine and the betterment of public health."

An absolute scale of temperatures is proposed by William Thomson (1824-1907). Thomson will become Baron Kelvin of Largs, in 1892, and the scale will come to bear his name.

Armand Hippolyte Louis Fizeau suggests that light from a source of moving away from the observer will be shifted toward the red end of the spectrum, a phenomenon known as redshift. This is closely related to, but not exactly the same as, the Doppler effect.

The American Association for the Advancement of Science is founded. Joseph Henry (1797-1898), who had been appointed the first secretary of the Smithsonian in 1846, is the first secretary of the AAAS, which is modeled after The British Association for the Advancement of Science. The British Association has been in existence for 17 years.

The American Association for the Advancement of Science is established.

1848

Edmond Becquerel makes the first full-color photographs, but they are only laboratory curiosities: an exposure lasting hours or days is required and the colors are so light-sensitive that they sometimes fade right before the viewer's eyes while being examined.

Botanist Carl Friedrich von Gärtner (1772-1850) publishes Versuche und Beobachtungen über die Bastarderzeugung im Pflanzenreiche. The book describes thousands of experiments, many involving the production of hybrids, on more than 500 species of plants. Mendel will study this book in detail when he attends the University of Vienna in the early 1850s, and will cite the book in the opening of his paper of 1865.

Based on a humerus 58 inches in circumference, Mantell names a new dinosaur species: Pelorosaurus, the first recognized sauropod.

Armand Hippolyte Louis Fizeau measures the velocity of light in error by measuring the time it takes for a beam of light to pass between the teeth of a rotating gear. The light is reflected by a mirror and stopped by the next tooth of the gear. The result, 315,000 km/se4c (196,000 miles/sec), is within 5% of today's accepted value.

In describing Sadi Carnot's theory of heat, published in 1824, William Thomson (1824-1907) uses the term THERMODYNAMICS.

The speed of light is measured by physicist Armand Hippolyte Louis Fizeau (1819-1896) to be approximately 186,000 miles per second.

1849

A unmanned Montgolfier balloon is used to drop bombs on Venice. This is the first time a bombing has been conducted from the air.

ESP Quick Facts

ESP Origins

In the early 1990's,
Robert Robbins
was a faculty member at Johns
Hopkins, where he directed the informatics core of GDB
— the human gene-mapping database of the international human
genome project. To share papers with colleagues around the world, he
set up a small paper-sharing section on his personal web page. This
small project evolved into The Electronic Scholarly
Publishing Project.

ESP Support

In 1995, Robbins became the VP/IT of the Fred Hutchinson Cancer Research
Center in Seattle, WA. Soon after arriving in Seattle, Robbins secured
funding, through the ELSI component of the US Human Genome Project, to
create the original ESP.ORG web site, with the formal goal of
providing free, world-wide access to the literature of classical genetics.

ESP Rationale

Although the methods of molecular biology can seem almost
magical to the uninitiated, the original
techniques of classical genetics are readily appreciated by one and
all: cross individuals that differ in some inherited trait, collect
all of the progeny, score their attributes, and propose mechanisms
to explain the patterns of inheritance observed.

ESP Goal

In reading the early works of classical genetics, one is drawn, almost
inexorably, into ever more complex models, until molecular explanations
begin to seem both necessary and natural. At that point, the tools
for understanding genome research are at hand. Assisting readers reach
this point was the original goal of The Electronic Scholarly Publishing
Project.

ESP Usage

Usage of the site grew rapidly and has remained high. Faculty began
to use the site for their assigned readings. Other on-line
publishers, ranging from The New York Times to Nature
referenced ESP materials in their own publications. Nobel laureates
(e.g., Joshua Lederberg) regularly used the
site and even wrote to suggest changes and improvements.

ESP Content

When the site began, no journals
were making their early content available in
digital format. As a result, ESP was obliged to digitize classic
literature before it could be made available. For many important
papers — such as
Mendel's original paper
or the
first genetic map
— ESP had to produce entirely new typeset versions of the works,
if they were to be available in a high-quality format.

ESP Help

Early support from the DOE component of the Human Genome Project was
critically important for getting the ESP project on a firm foundation.
Since that funding ended (nearly 20 years ago), the project has been
operated as a purely volunteer effort.
Anyone wishing to assist in these efforts should send an
email to Robbins.