A C++ library for building discrete event simulations. Adevs is based on the Discrete Event System Specification (DEVS) and Dynamic DEVS modeling formalisms; it supports parallel discrete event simulation and a runtime system for OpenModelica.

JaamSim is a free and open source discrete-event simulation software which includes a drag-and-drop user interface, interactive 3D graphics, input and output processing, and model development tools and editors.

AnyLogic is a graphical general purpose simulation tool which supports discrete event, system dynamics and agent-based modeling approaches. In discrete event simulation it roots to the same approach as GPSS, but provides additional features: combining different modeling approaches, dynamic animation, GIS integration (tile maps and shapefiles), DB-connectivity, DXF-import, rich experimental framework etc. Has a free PLE version available for educational and self-educational purposes.

Arena is a simulation and automation software developed by Rockwell Automation. It uses the SIMAN processor and simulation language.

Enterprise Dynamics is a simulation software platform developed by INCONTROL Simulation Solutions. Features include drag-and-drop modeling and instant 2D and 3D Animation.

ExtendSim is a general purpose simulation software package from Imagine That.

MS4 Modeling Environment is a general purpose DEVS methodology based software environment for discrete event and hybrid models. The combination of DEVS and System Entity Structure (SES) frameworks allows family of models prototyping and system of systems engineering (SoSE) modeling and simulation.

ProModel - a discrete-event simulation tool that also allows modeling of continuous processes. ProModel is used for evaluating, planning or designing manufacturing, warehousing, logistics and other operational and strategic applications.

Renque is general-purpose discrete event simulation software with integrated Visual Basic scripting and a graphical interface for design and operation.