As topic, very quick question. Sorry I couldn't find it anywhere on the forum.

Also, Impaired seems to affect a bit everything, someone also think it should affect dodge and parry as active defense are just routine checks, butdo you think it should affect saves like fortitude, will, toughness?

On the same line, it will affect any strength or power check but not the DC from a strength based attack or power damage right?

Impaired and disabled are very open to gm interpretation. They can be as narrow or as broad as the descriptor of the power and gm will allow. For example, someone wearing handcuffs might be impaired, but that impairment is probably only going to limit things the character can do with their hands rather then how well they can dodge attacks or suck up punches to the face. The gm's going to need to decide these things on a case by case basis depending on the descriptors involved.