Histone Demethylase Assay

Histone demethylation is the removal of methyl groups in modified histone proteins via histone demethylases. The discovery of histone demethylases demonstrates that histone methylation is not a permanent modification, but rather a more dynamic process. Specific demethylases are found to be involved in some pathological processes such as cancer progression, making it necessary to better understand the activity or inhibition of histone demethylases.