He made his television debut by appearing in Episode 76 of Yeh Hai Aashiqui, an Indian television series that presented dramatization of love stories and aired on Bindass. Later he portrayed the role of Bhuvan, the leader of handloom weavers on the television series ‘’Million Dollar Girl’’, which was televised by Channel V. Growing up in Hyderabad, he was not fluent in Hindi so he had to take Hindi diction classes to learn the language.

In 2015, he won the Mr India 2015 contest held on 23 July 2015 at Club Royalty in Mumbai, Maharashta. He also won two special awards at the contest, "Stay-On Mr Active" and "Provogue Personal Care Best Actor.

Mr. Rohit Khandelwal became the first Asian to win the title of Mister World at a ceremony on 19 July 2016 at Southport Theatre, Floral Hall, The Promenade, Southport. The competition saw 47 participants from around the world. Rohit Khandelwal received a cash prize of $50,000/- from winning the pageant. He also competed for various sub-titles at the pageant, including but not limited to Mr. World Multimedia Award, Mr. World Talent, Mobstar People’s Choice Awards, Mr. World Sports Event and won the subtitle of Mr. World Mutimedia Award.