Table 6

Cost estimates used in the decision analytic models. Costs in US dollars.

Costs

Model with all patients

Model in patients with APACHE II score >= 25

Source

Drug costs * (drotrecogin alfa)

$9,700

$9,700

MUHC (Pharmacy department)

Bleeding episode costs

$12,090

$12,090

Manns et al [40]

Hospitalization costs (severe sepsis episode)

$47,960

$51,095

Manns et al. [40]

1-year costs (after hospital discharge)**

$20,641

$29,879

Manns et al. [40]

Year 2 costs**

$6,641

$8,083

Manns et al. [40]

Year 3 costs**

$6,290

$5,762

Manns et al. [40]

* Drug costs refer to acquisition costs of drotrecogin alfa and were therefore used
only in this group. Other costs were assumed to be identical in both groups.

Costs from the article by Manns et al. [40] were converted to Canadian dollars according
to the exchange rate used in the article (US$1 = CDN$1.47) and adjusted for inflation
according to Bank of Canada rates.

** Costs with 3% discounting

This included direct health care costs for hospitalizations, emergency visits, day
surgeries, and physicians' costs [40].