Study Data from University for Health Sciences Update Knowledge of Connective Tissue Cells

NewsRx.com

08-23-13

By a News Reporter-Staff News Editor at Genomics & Genetics Weekly -- Current study results on Connective Tissue Cells have been published. According to news reporting out of Lahore, Pakistan, by NewsRx editors, research stated, "This study evaluated the effect of an antioxidant, Vitamin E, on cultured chondrocytes against H2O2-induced damage in vitro. Rat chondrocytes isolated from articular cartilage."

Our news journalists obtained a quote from the research from University for Health Sciences, "Chondrocytes were pretreated with either 50 or 100 mu M Vitamin E or serum-free medium for 24 h followed by their exposure to 200 mu M H2O2 for 3 h. Chondrocytes without exposure to H2O2 served as control group. The effect of Vitamin E pretreatment was evaluated by examining proteoglycan contents, nitrite levels, viability, apoptosis, and senescence of cultured chondrocytes. Proteoglycan contents increased in groups treated with Vitamin E. Semi-quantitative real-time PCR data also correlated with these results and demonstrated that Vitamin E up-regulated expression of Agc1, Col2a1, and PCNA genes along with down-regulation in the expression of Col1a1 and Casp3 genes. The differentiation index improved after Vitamin E pretreatment. Nitrite levels were reduced with a corresponding increase in cell viability. Reduction in apoptosis and senescence was also observed after Vitamin E pretreatment. Moreover, a dose-dependent effect of Vitamin E was seen. In contrast to 50 mu M Vitamin E, 100 mu M was more potent in inducing protection of chondrocytes from H2O2-induced oxidative damage."

According to the news editors, the research concluded: "Vitamin E reversed the oxidant-induced alterations in chondrocytes and may be a good option to pretreat chondrocytes before transplantation."

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