Disturbances of glucose homeostasis that result in hypoglycaemia is a common metabolic issue encountered in newborn. Most of the times, awareness of various risk factors that predispose infants to hypoglycaemia allows for screening of newborns at risk, so that clinically undetectable hypoglycaemia can be treated promptly, thus preventing the development of severe or symptomatic hypoglycaemia, which is associated with adverse outcomes. Persistent, recurrent or severe hypoglycaemia may cause irreversible injury to the developing brain. The present study reported outcome of seven neonates who presented with varied symptoms of persistent hypoglycaemia.