... Herein, an efficient methodology for the synthesis of a diverse class of N-heterocyclic moieties, such as quinoxalines, benzimidazoles and quinazolines, was developed in water using bio-renewable alcohols. The quinoxalines were successfully synthesized from a wide range of diamines and nitroamines with diols in air. Interestingly, benzimidazoles and quinazolines were synthesized with excellent iso ...

... The present study describes the first example of synthesis of pharmaceutically relevant N-heterocycles like substituted quinolines, acridines and 1,8-naphthyridines in water under air using alcohols in presence of a new water soluble Ir-complex. The viability and efficiency of this approach was demonstrated by the efficient synthesis of biologically active natural product (±)-galipinine and gram s ...

... A Ru(ii) complex mediated synthesis of various N,N-dimethyl and N-monomethyl amines from organic azides using methanol as a methylating agent is reported. This methodology was successfully applied for a one-pot reaction of bromide derivatives and sodium azide in methanol. Notably, by controlling the reaction time several N-monomethylated and N,N-dimethylated amines were synthesized selectively. Th ...

... A new phosphine-free Co(ii) complex-catalyzed synthesis of various quinoxalines via dehydrogenative coupling of vicinal diols with both o-phenylenediamines and 2-nitroanilines is reported. This complex was also effective for the synthesis of quinolines. The practical aspect of this catalytic system was revealed by the one-pot synthesis of 2-alkylaminoquinolines. ...

... Levulinic acid (LA) is an important platform intermediate for several high value renewable bioproducts. One-pot synthesis of LA from carbohydrates is disadvantaged by the lack of proximity of the active sites required for sequential isomerization, dehydration and rehydration reactions. Herein, we report an efficient one-pot conversion of C₆ sugars to LA using a carbo-catalyst (ZrHyC), containing L ...

... Ru(II) catalyzed tandem synthesis of α-branched methylated ketones via multicomponent reactions following the hydrogen borrowing process is described. This nonphosphine-based air and moisture stable catalyst efficiently produced various methylated ketones using methanol as a methylating agent. This system was found to be highly effective in three-component coupling between methanol, primary alcoho ...

... The catalytic activities of a series of in situ generated homogeneous ruthenium systems based on commercially available [RuCl₂(p-cymene)]₂ and various ligands in transfer hydrogenation of nitroarenes to anilines were investigated. Combination of [RuCl₂(p-cymene)]₂ and tridentate phenanthroline based ligand 2-(6-methoxypyridin-2-yl)-1,10-phenanthroline (phenpy-OMe) exhibited the highest catalytic a ...

... While the addition of C–H bonds to three-coordinate Ir(I) fragments is a central theme in the field of C–H bond activation, addition to square planar four-coordinate complexes is far less precedented. The dearth of such reactions may be attributed, at least in part, to kinetic factors elucidated in seminal work by Hoffmann. C–H additions to square planar carbonyl complexes in particular are unprec ...

... Evidence for key σ-complex intermediates in the hydrogenolysis of the iridium–methyl bond of (PONOP)Ir(H)(Me)⁺ (1) [PONOP = 2,6-bis(di-tert-butylphosphinito)pyridine] has been obtained. The initially formed η²-H₂ complex, 2, was directly observed upon treatment of 1 with H₂, and evidence for reversible formation of a σ-methane complex, 5, was obtained through deuterium scrambling from η²-D₂ in 2-d ...

... Carbon-fluorine bonds are the strongest known single bonds to carbon and as a consequence can prove very hard to cleave. Alhough vinyl and aryl C-F bonds can undergo oxidative addition to transition metal complexes, this reaction has appeared inoperable with aliphatic substrates. We report the addition of C(sp³)-F bonds (including alkyl-F) to an iridium center via the initial, reversible cleavage ...