Cholera is an important classical well-known infectious diarrheal disease. At present, it still exists in many tropical developing countries. In Myanmar, a tropical country in Southeast Asia, a recent outbreak is still observed in Yangon, Myanmar.[1] Hence, it is no doubt that cholera is still the problem of this area. The spread of problem to the nearby countries is of interest. Here, the authors discuss on the present problem of a new outbreak of cholera at the Thai-Myanmar border, which is an issue in transboundary tropical medicine. In October 2015, the problem of cholera outbreak occurred at the border area and there are many infected Myanmar patients who crossed the border to seek for a care in a Thai hospital (see report in http://www.maesotpost.com/?cid=1660701). Some death cases could be observed as well. To correspond to the problem, strict disease surveillance and prevention had been applied in the affected area. In fact, this is not the first time that the outbreak of cholera occurred in this area.[2],[3] Of interest, in the same period, there is, additionally, a transboundary outbreak of animal disease, the foot and mouth disease in cattle in this area, resulting in temporary closing of big cattle market in this area. Focusing on the Thai-Myanmar border, it is still considered a remote area with many underprivileged minorities. The focus on transboundary tropical medicine research in this area is warranted.