The James Bond novels and film series feature a number of villainous characters who serve as primary antagonists. Each story normally features a main villain bent on world domination or destruction who seeks to defeat or kill Bond, often with the assistance of secondary characters. Bond typically confronts the villain during the story's climax and exposes the evil plot.

Use a prototype Serbian weapon known as a "Cutter" to destroy a university in York, killing a cancer researcher who could ruin his employer, a pharmaceutical corporation.

Bond is able to warn British authorities about the Cutter before it detonates.

Shot by an associate, Niall Dunne.

Felicity Willing

Uses her position as head of the International Organisation Against Hunger to strategically distribute food aid across northern Africa, giving the government of the Sudan a pretext to go to war with the south.

She is tricked into confessing to the scheme by Bond and Bheka Jordaan.

Extradited to a secret location after evidence is planted to suggest she was embezzling money from her Chinese backers.

Niall Dunne

He assists Hydt in his operation, then betrays and kills him while working for Felicity Willing.

Sabotage US rocket test launch. Blow up Empire State Building with train bomb and make it appear to be the rocket's doing by spreading debris of duplicate rocket around bomb site. Use public outcry to give USSR advantage in the Space Race

Stage an elaborate revenge scheme against James Bond for the death of Dr No, by stealing a Russian cryptographic device. Bond will be assigned to recover the device, where SPECTRE's hired assassin Red Grant, will kill Bond. They will then leak compromising photos of Bond and the Russian pawn, Tatiana Romanova, to the press and then sell the device back to the Russians.

Bond acquires the device for MI6 and evades SPECTRE's attempts on his life.

Abduct beautiful women from around the world and use them as pawns to spread a dangerous virus that is capable of destroying crops and livestock unless the United Nations agree to pardon him for his past crimes.

Bond, with the help of Marc Ange Draco, destroys the laboratory where the viruses are being developed before they can be released.

Capture a British submarine and a Soviet submarine and fire a nuclear warhead from both, luring Britain and the Soviet Union into a nuclear war and rebuild human civilization underwater once the war is finished.

Bond redirects the British and Soviet nuclear missiles' coordinates so that the missile fired by each sub hits the other, destroying both.

Fire a nerve agent from space, poisoning Earth's atmosphere and killing off the human population. Rebuild humanity in space with carefully selected humans, creating a new master race before returning to repopulate the Earth once the nerve agent is rendered harmless.

The space station containing the poisonous globes is destroyed by US Marines, and the three globes that were launched were destroyed by Bond and Holly Goodhead before they could release their payload.

Smuggle a bomb into a U.S. Air Force Base in West Germany and detonate it, tricking Western powers into disarmament and allowing the Warsaw Pact to invade and conquer Western Europe without fear of retaliation.

Bond disarms the bomb.

While attempting to jump on Octopussy's circus train, he is shot and killed by East German border guards mistakenly believing he is trying to defect.

Develop a bomb and activate it under Silicon Valley, triggering an earthquake in California and cause the valley to flood, wiping out his competitors and allowing him to monopolise the microchip market.

Zorin leaves May Day to die in the bomb blast. Enraged at his betrayal, she smuggles the bomb out of the blast radius, ensuring that no other damage is caused.

Hijack the eponymous satellite with his Janus syndicate, and use the satellite to emmit an electro-magnetic pulse, creating a financial meltdown in London as the pulse will interfere with the Bank Of England's computer systems.

Bond destroys the GoldenEye by sabotaging the ground transmitter, causing the GoldenEye to burn up on re-entry.

Bond drops him to the bottom of the antenna cradle. Somehow surviving this, he is soon crushed by the rubble and remains of the GoldenEye ground transmitter.

Act as the middleman in the distribution of funds between terrorist banker, Le Chiffre and his respective clients. He is later tasked with eliminating Le Chiffre, who has been branded as a liability to White's people.

Dispatches Le Chiffre and retrieves the money but is ultimately apprehended by Bond.

Gain world power by infiltrating the world's intelligence agencies and bringing them under his control via a surveillance program called "Nine Eyes". Also desires to torment and eliminate Bond for supposedly stealing his father's love and for meddling with his previous schemes.

Bond destroys Blofeld's Data Center and Q manages to disable the "Nine Eyes" program before it can be activated.

SMERSH – SMiERt SHpionam, "Death to Spies," Bond's original nemesis in the novels, though only taking an active role in the 1967 film Casino Royale and only briefly mentioned in the others (apparently disbanded 20 years before the events of The Living Daylights). The Soviet agency is in charge of assassination, loosely based on the real-life SMERSH.

SPECTRE – SPecial Executive for Counter-intelligence, Terrorism, Revenge and Extortion, first appeared in the novel Thunderball and replaced SMERSH as Bond's nemesis in the films. The independent terrorist organisation is headed by Ernst Stavro Blofeld. In the 2015 film, Spectre, 007 digs deep into the organisation and tries to get payback for his beloved M (Judi Dench); he discovers the organisation is headed by his adopted brother Franz Oberhauser, now calling himself Blofeld, and that its entire purpose was to personally persecute Bond himself.

BAST – Brotherhood of Anarchy and Secret Terrorism, featured in the novel Win, Lose or Die.

Quantum – A shadowy criminal organisation seen in Casino Royale and Quantum of Solace.[1] The organisation is strictly apolitical—but with considerable political influence of their own—and will deal with anyone whose interests converge with their own. Known members of the organisation include an extensive network of current and former politicians, business people and intelligence agents. One of their leading members, Dominic Greene, leads a cover organisation called Greene Planet. In Spectre (2015), the organisation is revealed as a division within SPECTRE rather than an independent group.

SCUM – Stands for "Saboteurs and Criminals United in Mayhem", the main villainous organisation in the James Bond Jr. series.

Phoenix International - Rafael Drake's organisation in Nightfire. Ostensibly a nuclear disposal company, Drake used it to weaponise the nuclear materials it got its hands on in his plan to rule the world.

King Industries - Sir Robert King's multinational oil and construction company in The World Is Not Enough and its novelisation and video game adaptations. It was formed through the merge of his own construction business and his wife's oil business.

Osato Chemicals and Engineering - Mr Osato's company, supplying chemicals and engineering equipment in You Only Live Twice, heavily affiliated with SPECTRE.