Because IQ is linked to so much else, psychometricians have long expected it to be polygenetic: Many genes have an input into it. I have always favoured the view that a high IQ is simply one aspect of general biological good functioning. The brain is just another organ of the body, after all. So if that is the case, the number of genes linked to IQ should be very large indeed. So the work below is just a first step.

Various reports of this study distort its results -- with the NYT in the lead on that. So let me answer them here:

The NYT says: "These genes do not determine intelligence, however. Their combined influence is minuscule". That is exactly the opposite of what the study found. I append the journal abstract below so readers can check for themselves. The authors found that their 52 genes explained 5% of the variance in IQ. That per cent of variance explained is about normal in psychological research and has been used to support many claims of causality. And the 5% will rise as more genes are analysed.

Other reports misunderstood the links to Alzheimers and Schizophrenia. The study found that people with high IQ genes had LESS Alzheimers and Schizophrenia, not more. It is interesting, however, that high IQ genes are associated with autism. As is well known, autistic people often have extreme mental abilities in some fields, so the finding is not too surprising. Most high IQ people are not autistic, however.

I liked the finding that high IQ people are tall, thin and unlikely to smoke. I am an example of that. I am 5'10", was very skinny in my early life and have never smoked. 5'10" is not that tall these days but when I was born 73 years ago it was. The average male height in Australia has increased 3" in the last 50 years.

Intelligence is one of the most investigated traits in humans, but so far, only a handful of genes have been associated with the trait.

Now, researchers have made a major advance in understanding the genetic underpinnings of intelligence, uncovering 52 genes for the trait, 40 of which are new discoveries.

In particular they found that many people with these genes are more likely to have other traits, including being tall, thin and unlikely to smoke.

Scientists hope the findings could provide new biological insights into brain function and understanding, and help to define the genetic component of IQ.

The findings also turned up a surprising connection between intelligence and autism that could one day help shed light on the condition's origins.

"For the first time, we were able to detect a substantial amount of genetic effects in IQ," said Danielle Posthuma, a researcher at the Center for Neurogenomics and Cognitive Research in Amsterdam, and the main architect of the study. "Our findings provide insight into the biological underpinnings of intelligence," she told AFP.

An international research team led by Vrije Universiteit Amsterdam studied genetic data from over 78,000 individuals. The data included information on DNA genotypes and intelligence scores, which led the team to discover new genes and biological routes for intelligence.

Despite high heritability estimates of 45 per cent in childhood and 80 per cent in adulthood, until now, only a few genes had been associated with. But the new study uncovered 40 new genes, most of which are mainly expressed in brain tissue.

Professor Posthuma said: 'These results are very exciting as they provide very robust associations with intelligence. 'The genes we detect are involved in the regulation of cell development, and are specifically important in synapse formation, axon guidance and neuronal differentiation.

'These findings for the first time provide clear clues towards the underlying biological mechanisms of intelligence.'

The results showed that people with the genes were more likely to have high educational achievements, and were also likely to be taller, not to smoke, and to have autism spectrum disorder.

In contrast, people with the intelligence genes were less likely to have Alzheimer's disease, depressive symptoms, smoking history, schizophrenia, high body mass index, or obesity.

Dr Suzanne Sniekers, who also worked on the study, said: 'These genetic correlations shed light on common biological pathways for intelligence and other traits.

'Seven genes for intelligence are also associated with schizophrenia; nine genes also with body mass index, and four genes were also associated with obesity. 'These three traits show a negative correlation with intelligence.

'So, a variant of gene with a positive effect on intelligence, has a negative effect on schizophrenia, body mass index or obesity.'

The researchers stress that future studies will be needed to clarify the exact role of these genes in intelligence in order to gain a more complete picture of how genetic differences lead to differences in intelligence.

Professor Posthuma added: 'The current genetic results explain up to five per cent of the total variance in intelligence.

'Although this is quite a large amount of variance for a trait as intelligence, there is still a long road to go: given the high heritability of intelligence, many more genetic effects are expected to be important, and these can only be detected in even larger samples.'

Intelligence is associated with important economic and health-related life outcomes1. Despite intelligence having substantial heritability2 (0.54) and a confirmed polygenic nature, initial genetic studies were mostly underpowered3, 4, 5. Here we report a meta-analysis for intelligence of 78,308 individuals. We identify 336 associated SNPs (METAL P < 5 × 10−8) in 18 genomic loci, of which 15 are new. Around half of the SNPs are located inside a gene, implicating 22 genes, of which 11 are new findings. Gene-based analyses identified an additional 30 genes (MAGMA P < 2.73 × 10−6), of which all but one had not been implicated previously. We show that the identified genes are predominantly expressed in brain tissue, and pathway analysis indicates the involvement of genes regulating cell development (MAGMA competitive P = 3.5 × 10−6). Despite the well-known difference in twin-based heratiblity2 for intelligence in childhood (0.45) and adulthood (0.80), we show substantial genetic correlation (rg = 0.89, LD score regression P = 5.4 × 10−29). These findings provide new insight into the genetic architecture of intelligence.

No comments:

Post a Comment

About

This blog is written solely by John Ray, who has a Ph.D. degree in psychology and 200+ papers published in the academic journals of the social sciences. It does occasionally comment on issues in psychology but is mainly aimed at giving a conservative psychologist's view on a broad range of topics. There are very few conservative psychologists. The blog originated in Australia and many (but not most) posts discuss Australian matters. Australians have an unusually good awareness of events outside their own country. Australian newspapers feature news from Britain and the USA not as an afterthought but as a major part of their coverage. So Australians do tend to have a truly Western heart, which is the reason behind the old name for this blog. So events in Australia, Britain and the USA all feature frequently here, plus occasional coverage of other places, particularly Israel.

A primer in American politics for non-Americans:

SCOTUS is the Supreme Court of the United States, the highest court in the land

The "GOP" stands for "Grand Old Party" and refers to the Republican party. The GOP is at present center/Right, while the Democrats have been undergoing a steady drift Leftwards and now have policies similar to mainstream European Leftist parties.

The ideological identity of both parties has however been very fluid -- almost reversing itself over time. In the mid 19th century, the GOP was the party of big government and concern for minorities while the Democrats advertised themselves as "The party of the white man" -- an orientation that lasted into the mid 20th century in the South. The Democrats are still obsessed with race but have now flipped into support for discrimination AGAINST whites.

Was Pope Urban VIII the first Warmist? Below we see him refusing to look through Galileo's telescope. People tend to refuse to consider evidence— if what they might discover contradicts what they believe.

Some brief observations about Leftism

As a good academic, I first define my terms: A Leftist is a person who is so dissatisfied with the way things naturally are that he/she is prepared to use force to make people behave in ways that they otherwise would not.

Leftists think that utopia can be coerced into existence -- so no dishonesty or brutality is beyond them in pursuit of that "noble" goal

Leftism is fundamentally authoritarian. Whether by revolution or by legislation, Leftists aim to change what people can and must do. When in 2008 Obama said that he wanted to "fundamentally transform" America, he was not talking about America's geography or topography but rather about American people. He wanted them to stop doing things that they wanted to do and make them do things that they did not want to do. Can you get a better definition of authoritarianism than that?

And note that an American President is elected to administer the law, not make it. That seems to have escaped Mr Obama

That Leftism is intrinsically authoritarian is not a new insight. It was well understood by none other than Friedrich Engels (Yes. THAT Engels). His excellent short essay On authority was written as a reproof to the dreamy Anarchist Left of his day. It concludes: "A revolution is certainly the most authoritarian thing there is; it is the act whereby one part of the population imposes its will upon the other part by means of rifles, bayonets and cannon — authoritarian means"

Evan Sayet: The Left sides "...invariably with evil over good, wrong over right, and the behaviors that lead to failure over those that lead to success." (t=5:35+ on video)

Some useful definitions:

If a conservative doesn't like guns, he doesn't buy one. If a liberal doesn't like guns, he wants all guns outlawed. If a conservative is a vegetarian, he doesn't eat meat. If a liberal is a vegetarian, he wants all meat products banned for everyone. If a conservative is down-and-out, he thinks about how to better his situation. A liberal wonders who is going to take care of him. If a conservative doesn't like a talk show host, he switches channels. Liberals demand that those they don't like be shut down. If a conservative is a non-believer, he doesn't go to church. A liberal non-believer wants any mention of God and religion silenced. (Unless it's a foreign religion, of course!) If a conservative decides he needs health care, he goes about shopping for it, or may choose a job that provides it. A liberal demands that the rest of us pay for his.

Death taxes: You would expect a conscientious person, of whatever degree of intelligence, to reflect on the strange contradiction involved in denying people the right to unearned wealth, while supporting programs that give people unearned wealth.

America is no longer the land of the free. It is now the land of the regulated -- though it is not alone in that, of course

Envy is a strong and widespread human emotion so there has alway been widespread support for policies of economic "levelling". Both the USA and the modern-day State of Israel were founded by communists but reality taught both societies that respect for the individual gave much better outcomes than levelling ideas. Sadly, there are many people in both societies in whom hatred for others is so strong that they are incapable of respect for the individual. The destructiveness of what they support causes them to call themselves many names in different times and places but they are the backbone of the political Left

The large number of rich Leftists suggests that, for them, envy is secondary. They are directly driven by hatred and scorn for many of the other people that they see about them. Hatred of others can be rooted in many things, not only in envy. But the haters come together as the Left.

Leftists hate the world around them and want to change it: the people in it most particularly. Conservatives just want to be left alone to make their own decisions and follow their own values.

The failure of the Soviet experiment has definitely made the American Left more vicious and hate-filled than they were. The plain failure of what passed for ideas among them has enraged rather than humbled them.

Ronald Reagan famously observed that the status quo is Latin for “the mess we’re in.” So much for the vacant Leftist claim that conservatives are simply defenders of the status quo. They think that conservatives are as lacking in principles as they are.

The shallow thinkers of the Left sometimes claim that conservatives want to impose their own will on others in the matter of abortion. To make that claim is however to confuse religion with politics. Conservatives are in fact divided about their response to abortion. The REAL opposition to abortion is religious rather than political. And the church which has historically tended to support the LEFT -- the Roman Catholic church -- is the most fervent in the anti-abortion cause. Conservatives are indeed the one side of politics to have moral qualms on the issue but they tend to seek a middle road in dealing with it. Taking the issue to the point of legal prohibitions is a religious doctrine rather than a conservative one -- and the religion concerned may or may not be characteristically conservative. More on that here

The Leftist hunger for change to the society that they hate leads to a hunger for control over other people. And they will do and say anything to get that control: "Power at any price". Leftist politicians are mostly self-aggrandizing crooks who gain power by deceiving the uninformed with snake-oil promises -- power which they invariably use to destroy. Destruction is all that they are good at. Destruction is what haters do.

Leftists are consistent only in their hate. They don't have principles. How can they when "there is no such thing as right and wrong"? All they have is postures, pretend-principles that can be changed as easily as one changes one's shirt

A Leftist assumption: Making money doesn't entitle you to it, but wanting money does.

"Politicians never accuse you of 'greed' for wanting other people's money -- only for wanting to keep your own money." --columnist Joe Sobran (1946-2010)

I often wonder why Leftists refer to conservatives as "wingnuts". A wingnut is a very useful device that adds versatility wherever it is used. Clearly, Leftists are not even good at abuse. Once they have accused their opponents of racism and Nazism, their cupboard is bare. Similarly, Leftists seem to think it is a devastating critique to refer to "Worldnet Daily" as "Worldnut Daily". The poverty of their argumentation is truly pitiful

The Leftist assertion that there is no such thing as right and wrong has a distinguished history. It was Pontius Pilate who said "What is truth?" (John 18:38). From a Christian viewpoint, the assertion is undoubtedly the Devil's gospel

"If one rejects laissez faire on account of man's fallibility and moral weakness, one must for the same reason also reject every kind of government action." - Ludwig von Mises

Because of their need to be different from the mainstream, Leftists are very good at pretending that sow's ears are silk purses

Among people who should know better, Leftism is a character defect. Leftists HATE success in others -- which is why notably successful societies such as the USA and Israel are hated and failures such as the Palestinians can do no wrong.

A Leftist's beliefs are all designed to pander to his ego. So when you have an argument with a Leftist, you are not really discussing the facts. You are threatening his self esteem. Which is why the normal Leftist response to challenge is mere abuse.

Because of the fragility of a Leftist's ego, anything that threatens it is intolerable and provokes rage. So most Leftist blogs can be summarized in one sentence: "How DARE anybody question what I believe!". Rage and abuse substitute for an appeal to facts and reason.

Their threatened egos sometimes drive Leftists into quite desperate flights from reality. For instance, they often call Israel an "Apartheid state" -- when it is in fact the Arab states that practice Apartheid -- witness the severe restrictions on Christians in Saudi Arabia. There are no such restrictions in Israel.

Because their beliefs serve their ego rather than reality, Leftists just KNOW what is good for us. Conservatives need evidence.

“Absolute certainty is the privilege of uneducated men and fanatics.” -- C.J. Keyser

"Almost all professors of the arts and sciences are egregiously conceited, and derive their happiness from their conceit" -- Erasmus

THE FALSIFICATION OF HISTORY HAS DONE MORE TO IMPEDE HUMAN DEVELOPMENT THAN ANY ONE THING KNOWN TO MANKIND -- ROUSSEAU

"Seest thou a man wise in his own conceit? there is more hope of a fool than of him" (Proverbs 26: 12). I think that sums up Leftists pretty well.

Eminent British astrophysicist Sir Arthur Stanley Eddington is often quoted as saying: "Not only is the universe stranger than we imagine, it is stranger than we can imagine." It was probably in fact said by his contemporary, J.B.S. Haldane. But regardless of authorship, it could well be a conservative credo not only about the cosmos but also about human beings and human society. Mankind is too complex to be summed up by simple rules and even complex rules are only approximations with many exceptions.

Politics is the only thing Leftists know about. They know nothing of economics, history or business. Their only expertise is in promoting feelings of grievance

Socialism makes the individual the slave of the state – capitalism frees them.

MESSAGE to Leftists: Even if you killed all conservatives tomorrow, you would just end up in another Soviet Union. Conservatives are all that stand between you and that dismal fate.

Many readers here will have noticed that what I say about Leftists sometimes sounds reminiscent of what Leftists say about conservatives. There is an excellent reason for that. Leftists are great "projectors" (people who see their own faults in others). So a good first step in finding out what is true of Leftists is to look at what they say about conservatives! They even accuse conservatives of projection (of course).

The research shows clearly that one's Left/Right stance is strongly genetically inherited but nobody knows just what specifically is inherited. What is inherited that makes people Leftist or Rightist? There is any amount of evidence that personality traits are strongly genetically inherited so my proposal is that hard-core Leftists are people who tend to let their emotions (including hatred and envy) run away with them and who are much more in need of seeing themselves as better than others -- two attributes that are probably related to one another. Such Leftists may be an evolutionary leftover from a more primitive past.

Leftists seem to believe that if someone like Al Gore says it, it must be right. They obviously have a strong need for an authority figure. The fact that the two most authoritarian regimes of the 20th century (Nazi Germany and Soviet Russia) were socialist is thus no surprise. Leftists often accuse conservatives of being "authoritarian" but that is just part of their usual "projective" strategy -- seeing in others what is really true of themselves.

"Why should the German be interested in the liberation of the Jew, if the Jew is not interested in the liberation of the German?... We recognize in Judaism, therefore, a general anti-social element of the present time... In the final analysis, the emancipation of the Jews is the emancipation of mankind from Judaism.... Indeed, in North America, the practical domination of Judaism over the Christian world has achieved as its unambiguous and normal expression that the preaching of the Gospel itself and the Christian ministry have become articles of trade... Money is the jealous god of Israel, in face of which no other god may exist". Who said that? Hitler? No. It was Karl Marx. See also here and here and here. For roughly two centuries now, antisemitism has, throughout the Western world, been principally associated with Leftism (including the socialist Hitler) -- as it is to this day. See here.

Leftists call their hatred of Israel "Anti-Zionism" but Zionists are only a small minority in Israel

Some of the Leftist hatred of Israel is motivated by old-fashioned antisemitism (beliefs in Jewish "control" etc.) but most of it is just the regular Leftist hatred of success in others. And because the societies they inhabit do not give them the vast amount of recognition that their large but weak egos need, some of the most virulent haters of Israel and America live in those countries. So the hatred is the product of pathologically high self-esteem.

"With their infernal racial set-asides, racial quotas, and race norming, liberals share many of the Klan's premises. The Klan sees the world in terms of race and ethnicity. So do liberals! Indeed, liberals and white supremacists are the only people left in America who are neurotically obsessed with race. Conservatives champion a color-blind society" -- Ann Coulter

Who said this in 1968? "I am not, and never have been, a man of the right. My position was on the Left and is now in the centre of politics". It was Sir Oswald Mosley, founder and leader of the British Union of Fascists

The term "Fascism" is mostly used by the Left as a brainless term of abuse. But when they do make a serious attempt to define it, they produce very complex and elaborate definitions -- e.g. here and here. In fact, Fascism is simply extreme socialism plus nationalism. But great gyrations are needed to avoid mentioning the first part of that recipe, of course.

Politicians are in general only a little above average in intelligence so the idea that they can make better decisions for us that we can make ourselves is laughable

A quote from the late Dr. Adrian Rogers, 1931–2005: "You cannot legislate the poor into freedom by legislating the wealthy out of freedom. What one person receives without working for, another person must work for without receiving. The government cannot give to anybody anything that the government does not first take from somebody else. When half of the people get the idea that they do not have to work because the other half is going to take care of them, and when the other half gets the idea that it does no good to work because somebody else is going to get what they work for, that my dear friend, is about the end of any nation. You cannot multiply wealth by dividing it."

A lesson in Australian: When an Australian calls someone a "big-noter", he is saying that the person is a chronic and rather pathetic seeker of admiration -- as in someone who often pulls out "big notes" (e.g. $100.00 bills) to pay for things, thus endeavouring to create the impression that he is rich. The term describes the mentality rather than the actual behavior with money and it aptly describes many Leftists. When they purport to show "compassion" by advocating things that cost themselves nothing (e.g. advocating more taxes on "the rich" to help "the poor"), an Australian might say that the Leftist is "big-noting himself". There is an example of the usage here. The term conveys contempt. There is a wise description of Australians generally here

Heritage is what survives death: Very rare and hence very valuable

Two lines below of a famous hymn that would be incomprehensible to Leftists today ("honor"? "right"? "freedom?" Freedom to agree with them is the only freedom they believe in)

First to fight for right and freedom,
And to keep our honor clean

It is of course the hymn of the USMC -- still today the relentless warriors that they always were.

If any of the short observations above about Leftism seem wrong, note that they do not stand alone. The evidence for them is set out at great length in a MONOGRAPH on Leftism.

You can email me (John Ray) here (Hotmail address). In emailing me, you can address me as "John", "Jon", "Dr. Ray" or "JR" and that will be fine -- but my preference is for "JR"

There are also two blogspot blogs which record what I think are my main recent articles here and here. Similar content can be more conveniently accessed via my subject-indexed list of short articles here or here (I rarely write long articles these days)