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To differentiate exposure to the newly introduced chikungunya virus from exposure to endemic dengue virus and other pathogens in Haiti.

Methods

We used a multiplex bead assay to detect immunoglobulin G (IgG) responses to a recombinant chikungunya virus antigen, two dengue virus-like particles and three recombinant Plasmodium falciparum antigens. Most (217) of the blood samples investigated were collected longitudinally, from each of 61 children, between 2011 and 2014 but another 127 were collected from a cross-sectional sample of children in 2014.

Findings

Of the samples from the longitudinal cohort, none of the 153 collected between 2011 and 2013 but 78.7% (48/61) of those collected in 2014 were positive for IgG responses to the chikungunya virus antigen. In the cross-sectional sample, such responses were detected in 96 (75.6%) of the children and occurred at similar prevalence across all age groups. In the same sample, responses to malarial antigen were only detected in eight children (6.3%) but the prevalence of IgG responses to dengue virus antigens was 60.6% (77/127) overall and increased steadily with age. Spatial analysis indicated that the prevalence of IgG responses to the chikungunya virus and one of the dengue virus-like particles decreased as the sampling site moved away from the city of Léogâne and towards the ocean.

Conclusion

Serological evidence indicates that there had been a rapid and intense dissemination of chikungunya virus in Haiti. The multiplex bead assay appears to be an appropriate serological platform to monitor the seroprevalence of multiple pathogens simultaneously.

National Center for Emerging and Zoonotic Infectious Diseases (U.S.), Division of Vector-Borne Diseases.

Published:

May 19, 2015

Description:

The prevention or reduction of chikungunya virus (CHIKV) transmission is completely dependent on the control of mosquito vectors and limiting human-vector contact. Several different mosquito species are involved in the transmission of CHIKV in Africa...

National Center for Emerging and Zoonotic Infectious Diseases (U.S.). Division of Vector-Borne Diseases.

Published:

8/26/16

Description:

The primary objective of this document is to provide guidance for Aedes aegypti and Aedes albopictus surveillance and control in response to the risk of introduction of dengue, chikungunya, Zika, and yellow fever viruses in the United States and its ...

National Center for Emerging and Zoonotic Infectious Diseases (U.S.). Division of Vector-Borne Diseases.

Published:

3/29/16

Description:

The primary objective of this document is to provide guidance for Aedes aegypti and Aedes albopictus surveillance and control in response to the risk of introduction of dengue, chikungunya, Zika, and yellow fever viruses in the United States and its ...