The complex interaction of genetic and environmental factors with the immune system is considered to be crucial for the development of immune and neurological disorders. Deciphering the pathogenesis of neuropsychiatric diseases remains a challenging task till date. This session opens with an invited lecture for an update on the role of the immune processes in the pathogenesis of Parkinson’s disease. The session also discusses how dietary components modulating the innate immune system could be useful for treating neuropsychiatric disorders. Subsequent presentations of selected abstracts will shed light on the pathophysiology of immune diseases, neurological and degenerative brain disorders and will provide insight in ways for drug targeting.