Contribution of thiol-based sensor dksA to Salmonella pathogenesis

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Abstract

Microbial pathogens like Salmonella utilize numerous strategies to rapidly sense and respond to a myriad of environmental stresses. Oxidative, nitrosative, and nutritional stress imposed by the innate immune response are prominent among the antimicrobial pressures encountered by Salmonella during their association with mammalian hosts. The stringent response to nutritional stress, which is under the control of the RNA polymerase-binding protein DksA and the nucleotide alarmone guanosine penta/tetraphosphate [(p)ppGpp], is essential for Gram-negative pathogens to respond to nutrient limiting ...