The main points seem to be that although having 1 or 2 risks doesn’t have much effect on your mortality, health or cognitive functioning when you start piling the risks on, things get worse. Hardly ground-breaking news but important I suppose in that epidemiology often looks at once risk at a time. What intrigued me were the measures used. There were some standard measures of metabolic syndrome (cholesterol, HDL: total cholesterol ratio, blood pressure, hip: waist ratio etc.) but also some measures which I understand (poorly) as measuring stress (i.e. twelve-hour overnight urinary cortisol excretion, twelve-hour overnight urinary excretion of norepinephrine, twelve-hour overnight urinary excretion of epinephrine, & serum DHEA-S level).
I get my cholesterol checked every few years, looking mostly at HDL:LDL ratio, and that’s about it.
I’m wondering, does anyone know any more about the ‘stress’ measures? Do other people use biomarkers as part of their health/ fitness regime? And, does anyone get any of these stress measures?

I measure salivary cortisol all the time. 24-hour cortisol, while it can be useful in a study like this (only have to deal with one data point, total cortisol), is not as useful in actually treating subclinical adrenal issues.

Measuring the catecholamines isn't something I know of many practitioners doing regularly, unless they are looking for a very specific issue (ie. adrenal tumor).

Is there a suitable primer on adrenal fatigue? Is it something I (37 years old, working in an office, playing martial arts and some kettlebells) should be monitoring for as part of my general health/ fitness practice?

Do you have a top 5 biomarkers, or any other tests you think everyone should be getting?