Using Plastics

Scientists link plastic compound to diseases.Chemical found in most of us may cause reproductive disorders.BY MARLA CONE ,Los Angeles Times Friday, August 3, 2007

In an unusual effort targeting a single chemical, several dozen scientists yesterday issued aStrongly worded consensus statement warning that an estrogen like compound in plastic is likely to be causing an array of serious reproductive disorders in people.

The compound, bisphenol A, or BPA is one of the highest-volume chemicals in the world and has found its way into the bodies of most human beings.

Used to make hard plastic, BPA can seep from beverage containers and other materials. It is used in all poly-carbonate plastic baby bottles, as well as other rigid plastic items, including large water cooler containers, sports bottles and microwave oven dishes, along with canned food liners and some dental sealants for children.

The scientists - including four from federal health agencies reviewed about 700 studies before concluding that people are exposed to levels of the chemical exceeding those that harm lab animals. Infants and fetuses are most vulnerable, they said.

The statement, published online by the journal Reproductive Toxicology, was accompanied by a new study by researchers from the National Institutes of Health finding uterine damage in newborn animals exposed to BPA. That damage is a possible predictor of reproductive diseases in women, including fibroids, endometriosis, cystic ovaries and cancers.

It is the first time BPA has been linked to female reproductive tract disorders, although earlier studies have found early stage prostate and breast cancers and decreased sperm counts in animals exposed to low doses.

The scientists statement and new study- along with five accompanying scientific reviews that summarize the 700 studies - intensify a highly contentious debate over whether the plastic compound poses a public threat. So far no governmental agency -here or abroad -has restricted it use.

Representatives of the plastics industry yesterday lambasted the scientists as alarmists and biased, and they said they based their conclusions on inconsistent and uncertain science.

“Considering many of these people have made their views known in the past, is there any surprise? Is there really anything new?” S Hentges of the America Chemistry Council’s poly-carbonate/BPA group.

Data challenge

Hentges said the scientists who signed the consensus statement were self-selected, leaving out many experts, and that many have conflicts of interest because they have either studied BPA and reported effects or “have already taken a very clear advocacy position.” “They are completely at odds with the findings of every governmental scientific body that has reviewed the same science,” he said.

Two government committees in Europe and Japan recently decided there is insufficient evidence to restrict the compound. Europe’s food safety agency decided in January that the data was inconclusive, largely because of metabolic differences between mice and humans, and because it is uncertain the amounts people are exposed to pose a human health threat.

Next week, a U.S. expert panel convenes to decide whether to declare BPA a human reproductive toxin, which could be a first step toward federal regulation. The review by the panel of the federal Center for the Evaluation of Risks to Human Reproduction, part of the national Institutes of Health, has been controversial. The Times reported in March that its preliminary report on BPA was written by a consulting firm with financial ties to the chemical industry that has since been fired by the center.

Frederick Vom Saal, a University of Missouri at Columbia reproductive toxicologist, said the scientists’ statement on BPA “is very different than any other approach to any chemical.”

“We now have, without a doubt, the most comprehensive set of documents covering every aspect of bisphenol A and the hope here is that government panels will actually look at this information, digest it, and incorporate it into their decision making,” said Vom Saal, who is the most vocal scientist studying BPA.

NO PEOPLE STUDIES

No studies have been conducted looking for effects in people, and one goal of the scientists who signed the statement is to generate human research.

Jerrold Heindel, a scientist with the National Institute of Environmental Health Sciences who organized a meeting last fall to begin drafting the statement, said en though there have been no human studies of BPA, there is now so much animal data that the 38 experts believe that potential human damage is likely. More than 150 studies have found health effects in animals exposed to low doses. “We know what doses the animals were given, and when we look at humans, we see blood levels within that range or actually higher, which is a cause of concern and should stimulate more human research,” he said.

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