Human corneal endothelial cells (HCEnCs) form a monolayer of hexagonal cells whose main function is to maintain corneal clarity by regulating corneal hydration. Cell loss due to aging or corneal endothelial disorders, such as Fuchs dystrophy, can lead to cornea edema and blindness, resulting in the need for cornea transplants. Studying human corneal endothelium has been difficult for cell biologists because limited cellular model systems exist and have significant drawbacks. The major drawback is that HCEnC cells do not divide and there is a limited source of these cells both for patient transplantation and for study in the laboratory. This field of study is now easier.