Efficient Preparations of Fluorine Compounds

The definitive guide to creating fluorine-based
compounds—and the materials of tomorrow

Discovered as an element by the French chemist Henri Moissan in
1886, through electrolysis of potassium fluoride in anhydrous
hydrogen fluoride—"le fluor," or fluorine, began its chemical
history as a substance both elusive and dangerous. With a slight
pale yellow hue, fluorine is at room temperature a poisonous
diatomic gas. Resembling a spirit from a chemical netherworld,
fluorine is highly reactive, difficult to handle, yet very
versatile as a reagent—with the power to form compounds with
almost any other element.

Comprising 20% of pharmaceutical products and 30% of
agrochemical compounds, as well as playing a key role in electric
cars, electronic devices, and space technology, compounds
containing fluorine have grown in importance across the globe.
Learning how to safely handle fluorine in the preparation of
innovative new materials—with valuable new
properties—is of critical importance to chemists today.
Bringing together the research and methods of leading scientists in
the fluorine field, Efficient Preparations of Fluorine
Compounds is the definitive manual to creating, and
understanding the reaction mechanisms integral to a wide variety of
fluorine compounds. With sixty-eight contributed chapters, the
book's extensive coverage includes:

Introduction of Fluorine into Compounds via Electrophilic and
Nucleophilic Reactions

Direct Fluorination of Organic Compounds with Elemental
Fluorine

Efficient Preparations of Bioorganic Fluorine Compounds

Asymmetric Fluorocyclization Reactions

Preparations of Rare Earth Fluorosulfides and
Oxyfluorosulfides

The book offers methods and results that can be reproduced by
students involved in advanced studies, as well as practicing
chemists, pharmaceutical scientists, biologists, and environmental
researchers. The only chemical resource of its kind, Efficient
Preparations of Fluorine Compounds—from its first
experiment to its last—is a unique window into the centuries
old science of fluorine and the limitless universe of
fluorine-based compounds.

HERBERT W. ROESKY, PhD, is Professor Emeritus of
Chemistry at the University of Göttingen and past president of
the Academy of Sciences of Göttingen. He is a recipient of the
ACS Award for Creative Work in Fluorine Chemistry and the H.
Moissan Award in Fluorine Chemistry.

“As Prof. K. Barry Sharpless comments in the Foreword,
‘Many years of experience, together with deep and catholic
knowledge of chemical reactivity principles, is the important coin
in this [fluorine chemistry] realm’, and I would recommend
this book to anyone involved in synthetic chemistry interested in
laboratory synthesis involving fluorinating reagents or fluorinated
molecules as an introduction into the experimental and chemical
reactivity possibilities now available.”
(ChemMedChem, 1 August 2013)

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