Geron recently announced that it had begun enrolling patients in the world's first-in-human clinical trial involving cells derived from human embryonic stem cells (hESCs). This trial raises important questions regarding the future of hESC-based therapies, especially in spinal cord injury (SCI) patients. We address some safety and efficacy concerns with this research, as well as the ethics of fair subject selection. We consider other populations that might be better for this research: chronic complete SCI patients for a safety trial, subacute (...) incomplete SCI patients for an efficacy trial, and perhaps primary progressive multiple sclerosis (MS) patients for a combined safety and efficacy trial. (shrink)

Following Wallace’s suggestion, Darwin framed his theory using Spencer’s expression “survival of the fittest”. Since then, fitness occupies a significant place in the conventional understanding of Darwinism, even though the explicit meaning of the term ‘fitness’ is rarely stated. In this paper I examine some of the different roles that fitness has played in the development of the theory. Whereas the meaning of fitness was originally understood in ecological terms, it took a statistical turn in terms of reproductive success throughout (...) the 20th Century. This has lead to the ever-increasing importance of sexually reproducing organisms and the populations they compose in evolutionary explanations. I will argue that, moving forward, evolutionary theory should look back at its ecological roots in order to be more inclusive in the type of systems it examines. Many biological systems (e.g. clonal species, colonial species, multi-species communities) can only be satisfactorily accounted for by offering a non-reproductive account of fitness. This argument will be made by examining biological systems with very small or transient population structures. I argue this has significant consequences for how we define Darwinism, increasing the significance of survival (or persistence) over that of reproduction. (shrink)

We resolve a useful formulation of the question how a statistician can coherently incorporate the information in a consulted expert’s probability assessment for an event into a personal posterior probability assertion. Using a framework that recognises the total information available as composed of units available only to each of them along with units available to both, we show: that a sufficient statistic for all the information available to both the expert and the statistician is the product of their odds ratios (...) in favour of the event; that the geometric mean of their two probabilities specifies a contour of pairs of assertions in the unit-square that yield the same posterior probability; that the information-combining function is parameterised by an unknown probability for the event conditioned only on the unspecified information common to both the statistician and the expert; and that an assessable mixing distribution over this unspecified probability allows an integrable mixture distribution to represent a computable posterior probability. The exact results allow the identification of the subclass of coherent probabilities that are externally Bayesian operators. This subclass is equivalent to the class of combining functions that honour the principles of uniformity and compromise. (shrink)

Frédéric Chopin is the epitome of the romantic artist; he had a chronic pulmonary disease that ultimately caused his death at the age of 39. An overlooked neurological condition is discussed in this paper. We consider the possibility of a temporal lobe epilepsy, as throughout his life Chopin had hallucinatory episodes, which can accompany seizure disorders.

This paper analyses the life and work of the historian Frederic C. Lane, Assistant Director of the Social Sciences for the Rockefeller Foundation in Europe, 1951–1954. During this period, Lane worked in close contact with Joseph Willits – head of the Social Sciences Division – and contributed to the definition of Rockefeller policies towards Europe during an early stage of the Cold War.