do jets, especially four engined jets, have to make a specific type of vector adjustment on long haul flights as fuel weight in the wings diminishes?

the reason i bring this up is seeing photos of the a340 at take off, with a full wing flex, which makes the engines look like they are actually vectoring upward by tilting the intakes toward the tarmac. i'm sure that the wing flex is dynamic throughout the flight and has to be compensated for, but how?