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Accelerated Chromatographic Isolation

ACI (Accelerated Chromatographic Isolation) converts simple flash purification into a faster and more economical way to isolate pure compounds.

Supplier Biotage believes that ACI will radically improve the efficiency of the laboratory, embracing the latest developments in purification technology to guide chemists towards improved chromatography.

With running costs a concern in most laboratories, ACI will move users to the end-point even faster. Traditional purification taking more than 15 minutes is reduced to 5 minutes; a 250mg scale laboratory scale experiment can now be purified in less than 3 minutes on a 10g column with an ACI enabled Biotage Isolera flash purification system.

“Chemists will now have freedom to work on other things while they let their ACI system do the purification. It is fully automated, reliable and lightning fast, we can completely purify 250 mg of sample in less than 3 minutes, this is quicker than most people take to run the TLC,” says Dr Sunil Rana, Global Product Manager, Biotage.

Biotage Isolera systems already recommend cartridges based on the sample size and programmed TLC data; they work out the best solvent gradient based on compound, and provide real time indication of eluting compounds, using UV, ELSD or Mass Detection. They subtract signal baselines automatically, so chemists can be confident that the correct fractions are collected.

ACI radically improves this, working seamlessly with the Biotage Isolera system, the simple wizard quickly guides chemists through the system, beneficial for new users or those whose expertise or priorities lie in synthesis rather than purification. Existing Biotage Isolera systems can be upgraded to ACI systems, and ACI will come as standard on all new production systems.