Note:-
(i)When there is reference to animals being 'sacrificed', this refers to
the animal(s) being killed.
(ii)'Obbed', 'Obbing' or 'Ob' which frequently occur in the diary refer to
'Observed', 'Observing' or 'Observe'.
Terry and Lynn X-rayed a dog from study 3327. I 'asked what was wrong and Terry said
sarcastically that's what I'm trying to find out. Terry read the x-ray and said what a, sweet irony-
it's a clean break in the exact same place in the exact same leg that we need for the bone
study. She and Lynn both laughed. Terry wrapped the dog's leg in a metal splint.
Lynn told me they thought his leg got broken in the exercise cage that there was a big hole near
the door where a lot of the wires were bent down.

I told her all the exercise cages are broken
and everyone tells me not to worry about it. That a couple of them have those holes and on
some the latches are broken so the dogs fall out if the door isn't
clipped.

3/15/97 Saturday HLS

I read the vet request for the dog with the broken leg in study 97-3327 room 922. The vet
request was written on the sixth of March. Terry recorded that she thought it was a fracture but
was unable to x ray it because there are no x-ray supplies. Cathy Kelly responded to hold off
euthanasing the dog until an x-ray was taken. Terry wrapped the leg and authorized one single
injection of butenorol for pain. She wrote on the vet request that it was obviously painful for the
dog. A second vet request was written on the 13 when she x rayed the dog. She wrote the
fracture was a clean break all the way through. She wrote no pain medication is needed ??
double-check verbatim on vet request (photo).

I checked the animal husbandry record in the room again. The viability records show that
Penny, a new associate technician and part of Dean Rodwell's dedicated animal care staff, who
signs her initials JG, signed for cleaning the room on the fifth. The dog was obbed on the sixth
as limping.

There is no treatment recommended for the DSI validation dogs even though vet requests have
been filled out for swollen implant sites.

I obbed and cleaned 3327. The dog with the broken leg hobbles around with the metal splint.
There were several pieces of chewed up bandaging material in the bottom of his cage. The
portable exercise cages have all been fixed as far as I can tell except for a broken latch on one.
There were two regular cages joined together in 3327 for exercise. The room is very crowded
with full cages and the only place to keep the double cage is in the
centre of the room.

Today
when I went in it was pushed up tightly against two other sets of cages, depriving the four dogs
in the cages of light and ventilation. All they could see from their cage doors was the backside
of a stainless steel cage- essentially they were enclosed overnight in solid metal boxes. I left the
cage in the centre of the room when I was through cleaning Yao fed them a short time later and
when I walked by in the afternoon, the double cage was pushed tightly against two other cages,
again depriving four more dogs of light and ventilation. Even when the cages aren't shoved into
other cages it limits the views of several dogs. Many of the dogs have nothing to look at but the
exercise cage about a foot away from their cage.

In study 3335 the same thing happened- the double cage was shoved up against two others. I
don't know how long the dogs had been left like this.

In 3093, the extra primate colony, 10 out of 39 primates have no mirrors. It's a common
occurrence for several monkeys in each room to be without a mirror until a cage change when
they may be lucky enough to get a cage with a mirror attached.

Page 83.

No one pays close attention to this enrichment
and when I've questioned putting them on before moving clean cages to rooms,
techs (Rachel, Stephanie, Brian) have told me we'll worry about that later. .
I heard dogs in study 3337 screaming as they were IV dosed with lidocaine/dexamethorphane
drug that supposedly will be used for migraines. In 3335, the Ritalin study, I found tablets in
capsules in cages of a group one and group seven dog.

Number 7736F was salivating
excessively when I went in to clean. I She was hiding her head under the food dish, her skin
was red, there was blood on her cage and she was rolling and acting wild. There was a pool of
saliva on the floor below her cage. All of group seven were salivating but not as excessively as
she.

In room 902, the ceiling is falling in. Along piece of sheet-rock tape is hanging from the ceiling
over some of the dogs' cages. There are pieces or the ceiling that are patched in places and
that's what's falling into the cages. I found several chunks of plaster and a lot or dust in one of
the group two dog's cages from the ceiling (photos).

In room 910, study 3323, there is a plastic garbage bag tied around the plumbing fixtures. It's
hanging in tatters, but obviously helping to keep the faulty plumbing from soaking the end dog,
number 2220.

In 3282, the bone study, the dogs are extremely scared and shy. Some of them bark normally,
some have very peculiar, raspy barks, some only whine and I have yet to hear some of them
bark.

I saw cage sores on some of the dogs' feet that were not obbed in the viability record. Dog
#8185 has a cage sore on foot and some of the dogs in 3282 are very thin (photos).
In room 947 - dogs who can bark, 8193,8197,8189 - weak, 8181 - weak.

In room 950 - dogs who can bark 8212, cant' bark - 8219 has no bark but can whine, 8205
photos, 8216 is very afraid (photos).

3/16/97 Sunday HLS

I obbed and cleaned 3327. Again, the exercise cages were pushed up against the cages with
dogs in them (photo). I took photos of the dog with the broken leg.

When I told Brian about this he said part of that might be his fault because he told Nick to put an
exercise cage in the rooms. Then he quickly said I didn't mean for him to put two of them in. I
don't know if a single cage constitutes an exercise cage but I know that two dogs exercised
together per sop and protocol requirements cannot be put in a single
cage at the same time.

In the extra primate colony, 10 primates are still without mirrors.

In study 3337, when the dogs are IV dosed they struggle and salivate. The rest of the dogs in
the study groups 1-7 are dosed with syringes of liquid test material pushed in nasally.
Brian forged some documents and some husbandry records, telling me as he did it "We don't do
this..." even as he told me to help him do it.

Page 84.

In 3335, dog number 3776F was salivating excessively after dosing again. Her mouth gets all
red and her ears are soaked with slippery saliva.

In room 949, study 95-3282, the dogs are so afraid and un-socialized they dash to the back of
the cage and circle frantically looking for a place to hide. They slink down and when the door is
opened they turn frantic circles looking for somewhere to hide.

In 3323, one of the dogs in group two has a cage sore on his foot. I don't think the dogs in this
study can see well anymore. The high dosage group, especially, seem to not be fully sure
where I'm standing when I'm in front of them. I think they react according to what the other dogs
in the room do. They just never seem to look directly at me the way the lower dosage groups
do. They look just above or past me when I'm in front of them.

I sent E-mail to Eleanor with a carbon copy to Gene about the exercise cages being pushed up
against the dogs' cages in 3327 and 3335. I also informed her the ceiling in 902 is falling down
and the plumbing in 910 is faulty.

3/19/97 Wednesday HLS

Eleanor answered my E-mail saying she'd look into it. I noticed the cages were still in 3327 and
3335. The ceiling was fixed in room 902, but 910 still has a plastic bag tied around the
plumbing. Gene responded, "Let me know what happens."

The Magainin dogs in study 97-3632 started a l20 hour infusion dose today. The pharmacy was
unable to properly mix the group four-dose solution. They used a water-based solution that
doesn't mix with the oil-based vehicle the test material is mixed with and it started to separate.
As a result, the group four dog was dosed at least an hour later than
the others.

Terrence Gittens, the QA auditor, told Brian in the morning he needed to observe dosing and
Brian should call him when he's ready to start. Brian had already hooked the first dose bag up
when I reminded him about Terrence. Brian phoned him and continued to dose. Terrence
arrived and saw one bag of test material being attached to a pump. He groaned when he heard
the group four dog wouldn't be ready to dose for another hour or
more.

He said if it was after a
certain time that afternoon, he wouldn't be there - he would be at the airport. After talking about
the possible dose time a little more, he looked at me and said "1 guess I saw enough. That's
good enough for me." Then he left.

Irene told me the day before they had trouble with her Magainin rat study 97-3621. She said the
group two test materials separated in the syringes. Lisa had asked her why the material was
two different colours -clear and milky. She said they panicked because the test material was
already being delivered to the rats and they didn't know if they were getting straight test material
all at once, or air or what. She said they ended up giving the group two rats group three test
material at a slower rate. I asked if that wouldn't really alter the
results.

Irene shrugged and said
they didn't know. I asked her if the rats getting straight test material in group two after it
separated wouldn't really alter the whole study since it's so toxic. She said in the other rat study
they didn't start seeing deaths until the recovery period so she didn't
know.

Page 85.

Yao, Lisa, Irene and Rodney were all in the Magainin rat study 3621. One of the group four
syringes was occluded. Irene pointed out the test material in the catheters going from the
syringe pump to the rat looked like it was separated in the group two rats and some of the
others. She said she couldn't tell if it was air or test material. She hoped it wasn't air because
that much air in an animal the size of a rat could cause an
anabolism.

Gene came by and
looked at it and said it looked like the test material had separated from the vehicle, the lipid,
again. He said it was separating because it's being delivered at such a slow rate in the group
two's. He laughed at Irene's suggestion that if it was air it would kill the rats, saying, "Rats can
take a lot."

He said, "For one thing, the lipid and test material need to be mixed with a special machine and
it wasn't." I asked why it wasn't. He said we didn't have the
machine.

I was in pharmacy getting a vial to put the leftover test material from 3621 in. Brian, Dian - the
study director and three of the pharmacy people were there. They were all talking about what I
should do with the leftover test material. Someone mentioned just putting it down the drain. Dian
said, "Don't tell me! I don't want to know." Brian said, "We often just throw it away." She said
again "1 don't want to know." I agreed we had just thrown out the leftover bags of dose material
from the last dog study. [Irene told me later they hadn't thrown the entire bags of leftover out,
they had returned them to pharmacy because they had to re-use the test material for her study.
I saw IV lines with test material in them in the trash after Magainin
infusion studies.]

The
pharmacy techs and Brian talked about what could get incinerated and what couldn't. Brian
mentioned an Acea material that was floating over Pennsylvania even as we spoke, and
everyone groaned and laughed nervously. Dian said again, "I don't want to know! Don't you
guys get it? If I don't know I can just plead ignorance, but if I know, I have to tell you not to do it.
So don't tell me!"

This thought process of 'what [people] don't know...' is commonplace at Huntingdon, and in fact
seems to be the only thing that keeps the lab in operation. I have seen many of the people I
work with at the lab routinely alter 'little' bits of information, intentionally leave information out
when documenting or relating data, intentionally create vague responses to problems and
anticipated problems, routinely write memos to add to study files explaining why the rules
weren't followed.

This is extremely common and because they have all the rules spelled out in
SOP's everything always looks 'ship-shape' on paper and when queried. You have to know
what, specifically, to ask for to discover all the inaccuracies - and one almost always leads to
another.

Lisa told me she had filed a grievance with the IACUC about study 3318 when it was going on,
she was the primary tech. She said the test material was supposed to increase red blood cells
and it did. She said the vehicle was human blood serum but it was more pure than anything
they had used before and a lot of the dogs had allergic reactions to it. She said there were so
many dogs getting so sick from the test material that they were throwing up blood and
[urinating] and [defecating] blood.

The dogs were going into anaphylactic shock after having
allergic reactions to it. She said we had to stay late all the time, like 'til seven at night because
there were dogs in comas from dosing at ten in the morning. She said Irene and Al?? had
moved one dog into critical care because he was so sick from the test material. She said she
notified IACUC and they called the sponsor, who said they expected allergic reactions to it and
it was okay to administer an antihistamine after dosing to the dogs that needed it. She said she
was really mad because the sponsor knew about it but wouldn't say
anything.

Page 86.

She was complaining about all of the dogs in her bone study being so sick. I asked if Terry
couldn't keep the test from going on. She said she didn't think so.

Lisa and I walked past room 902, study 3335, in the middle of the afternoon. I pointed out the
double exercise cage pushed tightly against other cages with dogs in them, depriving the dogs
of light, sight and air. Lisa and I went in and moved the cages to the centre of the room where
they still deprive several dogs of a view other than a steel wall a foot away but at least they get
a little light and some air.

3/20/97 Thursday HLS

Cleaned DSI dogs. The surgeries were done more than two weeks ago, and there still has been
no data collected from the implants. Irene told me Al has not had any time to set them up. Last
week Al and Irene had told me the DSI system wasn't really working, AL was having trouble
getting it set up. Each of the wires going from the DSI receiver to the computer box cost $500.
So far the dogs have chewed up three that I know about.

The dog's implants look better. The swelling around the implants have gone down. Because of
the implants the dogs are not allowed to exercise together, or at all. There is a single extra cage
in the room below one of the dogs. Irene told me I could put the dogs in that cage when I
cleaned if I wanted to. Otherwise I could just leave them in their own cage while I cleaned. I
think that's what everyone else does.

The dogs are so starved for attention and exercise they
literally throw themselves out of their cages at me when I open the cage door.
Cleaned 3623 (Magainin) dogs. The puppies are very isolated. So much of their little bodies are
covered with dosing paraphernalia there's hardly a spot for me to pet them. I usually try to rub
their faces arid slide my fingers under the tight collars to rub the skin on their necks. They press
forward when the door is opened and have to be pushed in.

Gene told me in the UK dogs in infusion studies wear jackets and vests with pockets in them to
hold the pumps and the dose material. He said everything has to be right on the dog so they
aren't attached to a tether. The dosing bags are smaller because of it and have to be changed
frequently - round the clock if it's a continual 24-hour dose. He said it's because of stricter
animal rights laws, tethers aren't allowed because they impinge the
dog's freedom.

Helped Brian dose his dogs.

Helped Irene and Yao dose rats in 3621.

Brian, Irene and I bled dogs in 3623. When Irene and I tried to bleed dog number 2750 she
struggled so much I couldn't begin to hold her still. She yelped and cried whenever the needle
got close to her neck. Irene had Brian hold the puppy down when he came in and she tried to
bleed her. The dog W3S so afraid she urinated before Irene got enough
blood.

Brian's shirt was
soaked with urine and he was furious. He picked the dog up by the skin on her back and by the
collar and threw her roughly down oil the sling cart. He tied her into the sling, pulling the ropes
around her legs extremely taut in his anger. He obtained the blood sample from her leg cursing
at her the whole time. A tour came by and peered in the window at Brian as he bled the dog.
Irene tried to tell him but he just ignored her.

Page 87.

I cleaned and fed 3282. Most of these dogs (who are from Harlan/Ridglan and will be used in
the bone breaking study) have to be dragged forward by the scruff of their neck to be put into
the exercise cage. Even the few who come to the front of the cage slink back when I reach for
them. They dig their feet into the cage grate and stiffen their legs. Terry told John, who works in
cage washing and large animals to go in and pet the dogs in this study everyday for an hour
(every day he works). They're so fearful and un-socialized it's doubtful any amount of petting will
help them at this point.

Gene, Terry, and Lisa are all very upset about the condition of the dogs in 3282. Terry tried to
refuse the shipment when they first came in but they were accepted anyway. They have a lot of
health problems, are all different sizes and ages and are completely un-socialized. Everyone is
very upset about having to work with these dogs.

3/22/97 Saturday HLS

Yao and I medicated the dogs in 3282. It took a full hour to fulfil the 17 or more vet requests.
Most of the dogs were treated for otitis, conjunctivitis, and abscesses on their feet. Yao followed
up on conditions noted previously, however, he didn't notice any additional health conditions.
When lobbed in the afternoon I found an additional four dogs (?) with lacrimation (conjunctivitis)
and one dog whose cage was full of blood from a large sore on the bottom
of her foot.

I filled out
a vet request for her and asked Terry, who normally is not in on the weekends, to look at the
dog. She told me "These dogs are crap dogs. Rejects." She told me "[she] had told Cathy Kelly,
the study director they shouldn't be put on study." Terry told her "They are not healthy dogs and
should not be used and if they were used it would be a poor quality study." Terry said, "You
know what's going to happen if you take a dog with foot sores and wrap it up in a splint? That
tissue's going to get all black and stinky and it's going to get worse
and never heal."

She said
"Cathy is going to get half-way through the study and realize it and regret it." She said, "Cathy
Kelly told me 'They're dogs! They're going to have problems. What do you expect?"
Terry examined the dog and told me it was a weird dog with feet like a duck - they were
webbed. Where the pads on her feet were supposed to be individual pads separated by skin
they were all joined together. She started randomly grabbing dogs as she told me this [and I
mean grabbing - just flinging open doors and roughly dragging them out] saying, "Is this
normal? What are your feet like?"

She tried to grab one extremely shy, fearful dog next to the
one I had written up. I was shocked to see the veterinarian just grab whatever dog part she
could get a hold of and pull, dragging the frightened dog to the front of the cage. Finally, she
had a sloppy hold on each of the dog's upper legs and started pulling. These dogs are so
withdrawn they don't just give in and let themselves be dragged. They freak out and try to resist
by digging in their feet and trying to twist away. She had a very tight hold on the dog's legs and
was determined to get her forward.

I was surprised when the dog didn't get hurt with this rough
handling. The fifth dog she checked is extremely submissive and stayed frozen at the front of
her cage when Terry opened the door. Terry looked at me with big eyes and said, "Look! A dog
that doesn't run away. At one point she said all the dogs feet look like that. Then she said again
"These are reject dogs."

She wrote on the vet request "The dog's pads are keratinized..." She
wrote a treatment plan to soak the dog's foot in betadine. I asked her about the additional dogs
I'd found with lacrimation. She told me to treat them just like the others [with conjunctivitis] and
she'd sign the papers later. (I didn't treat them today because I felt she should sign the vet
requests first).

Page 88.

There were not enough forms in the ob book to write up additional vet requests
but I made some up on Sunday.

I asked her if we should be exercising the dogs in separate cages when we clean so they didn't
transmit conjunctivitis to other dogs but she said it was fine to double them up.
There are two other dogs with open sores on the bottom of their feet. The sores were not
noticeable until I picked them up for cleaning.

The draft protocol only calls for butorphonal to be administered once after surgery. There is the
standard guideline about administering analgesics as needed but I've never seen this done
when animals are in distress as a result of test material or
procedures.

Yao called the study director Dian Blaset to tell her rat number 1503 in study 3621 has a giant
seroma (the test material was collecting under the rat's muscle layer in her inner thigh and
abdomen area instead of going through the catheter right into the femoral vein). The seroma
was about the size of a golf ball. Dian told him to repair the site surgically using the other side of
the rat to implant the catheter. Yao told me the rat had obviously not been getting the test
material for more than 25 hours, evident by the size of the
swelling.

He said he had obbed the
rats the day before and in the morning and had not noticed it. He explained to me the protocol
only calls for observations from outside the cage and this is not noticeable from outside the
cage without taking each rat out and looking at them. He said he was able to do repair surgery
on the rat but he couldn't because he isn't certified. Al, Irene or Brian would have to come in to
do it.

Then he said Irene and Brian always get help with everything they do. They always have
Al come over and assist them. He said he, himself, doesn't say he can do something unless he
can and then he doesn't ask for help. Yao asked Terry about the rat and she said it's an infusion
study and the rat has obviously been off infusion for a long time and to repeat the surgery now
and continue the infusion would be futile. She drained about 5 mls of test material from the rat's
seratoma and it still looked large. Yao was taking the rat from the cage when he first noticed the
1190 and 1264 particularly have very long, overgrown nails that are curling around into their
pads.

The group seven dog in the Ritalin study 3335, still salivates and foams at the mouth for several
hours after test material administration. She lies down and throws her head around.
James was all hunched over near the feeder hole when I went in to see him. He reached out for
me right away when I knelt in front of him, then he quickly hunched over again. I don't know if
he's sick and is uncomfortable in any other position or if he's just miserable. He let me rub his
back and stroke his head for a while but he wouldn't take the treat I
offered him.

3/23/97 Sunday HLS

James was all curled up in a foetal position as usual and he flashed me his submissive grin
when I first went in - then he looked thoughtfully at me. He let me stroke his head and he
stretched his shoulders back so I could rub his tummy and chest. I stroked his cheek and he
tipped his head back and smiled just a little. When I got up to leave he resumed his foetal
position and tucked his head down low.

Page 89.

I helped Stephanie prepare NO dosing tubes for 3314. She said the ones they're using were
getting all yellow and gross looking. I asked her how long they can be used. She told me they
should really be replaced every two weeks but she lets it go longer than
that.

Stephanie has said this exact thing to me about cage changes, as have many other people.
They know it's supposed to be done every two weeks but they often let it
go longer.

3/26/97 Wednesday HLS

Today I cleaned room 953, the room holding the five dogs used in DSI validation surgeries.
When I signed for cleaning I saw no one had signed for feeding the dogs on Monday, 3/24/97.
On the schedule for Monday, Rodney was supposed to feed them. Because they are often
remembered only at the last minute, it doesn't surprise me no one fed them on Monday. The
computer system still hasn't been set up to gather data and because they aren't on study they're
often forgotten.

The dogs in this study are so lonely and starved for attention. 1190 just can't get enough
snuggling and 1272 is the same way. They are torn between running all over the room when I
let them out of their cages and just being held and loved. 1367 desperately wants to explore the
room when he's out, he's always racing from one smell to another. The female dogs, 1264 and
1255, are not sure what they're supposed to do but when I hold them they press their noses into
my neck.

The femoral catheter dogs in 3623 were taken off dose. The group three dog is sick from the
dose material, "slightly dehydrated", her cage is full of diarrhoea. The group three and four dog
are still being infused with saline.

Terry came in room 949 while I was cleaning to examine a dog she had "Like the 39th vet
request for ..." when someone came in to tell her the USDA inspector was there. He showed her
the inspector's card and told her she was waiting in QA. She kept saying "Now? Right now??"
Lisa and Rodney were taking x-rays of the dogs in room 950, study 3282. Terry told them they
couldn't do more than a couple at a time because the USDA inspector was there and someone
had to be with the dogs as they recovered from the anaesthetic. Lisa was sitting in front of what
she called "CCU", a stainless steel cage on wheels. When I went in after cleaning there were
three sedated dogs from 3282 in it.

I saw Rodney come in to get dog number 8211, she is extremely fearful arid always hides face
first in the back corner of her cage when the door is opened. I usually have to stand on the rack
of the cage below so I'm able to reach her scruff to drag her forward. When Rodney grabbed
her he grabbed a handful of skin on her side and dragged her forward sideways, even lifting her
out of the cage by the skin on her side. He's no taller than I am and it looked like whatever he
could reach he grabbed.

I watched Al bleed rats again in 3621. The rats are off infusion and the catheters have been tied
off. Irene showed me rat 1503, the rat with the big seroma. She said the catheter has come
through the skin and is all infected leaving a big open wound at the femoral site. She said
yesterday it was the loop of the catheter that was showing and the wound was surrounded by
black necrotic tissue - but it was sort of starting to heal over.

Page 90.

She said when they looked at it today, the rat had chewed off all the dead tissue and the plastic tubing was hanging out even
more. Irene wanted to put a staple in it to close it but Terry told her because it's an old wound
and not a fresh wound it wouldn't be a good idea - she said as long as it's open and draining it's
fine.

I picked the rat up later in the day and saw she had a one to one and a half inch open
wound (the whole length of the surgery site) open down to past the muscle layer. It's raw and
bloody looking with pus apparent way down in the opening. A piece of plastic tubing is visible
with a couple of inches hanging out of the wound.

A few hours after the bloods were done I noticed rat 4001's right eye was protruding from her
head and was so blood-filled and scabbed over it looked black. The area is swollen and the eye
is about twice the size of his other eye. He sits at the back of his cage with his head tipped to
the side, leaning his sore eye into the side of the cage.

Irene told me "That happens sometimes,
quite often actually, but usually not when Al does it." She said because rats' eyes protrude, they
dry out quickly. She said the rat's eye would dry up and fall out soon and we'd probably see it
lying on the floor. She said sometimes if you put lubricant on it right away sometimes it helps.
Lisa came in and saw the eye and said, "That's really gross!" Irene told AI, who looked at it and
said, "It's because whoever held it off didn't do it right." After he left the room, Irene said, "Al
always finds a way to blame someone else when something happens." Yao and Irene had held
the rat's eyes off after Al bled them.

The USDA inspector found a lot of problems with 3282. Terry showed her the vet requests and
explained technicians write requests and notify her to come and look at them. When the
inspector left the room, Terry gleefully hit Lisa on the arm and said, "We're covered! She's really
upset about the condition of the dogs and we're going to get written up for it but we've been
treating them so it's ok.

he company's going to look bad though - really, really bad."
Terry talked about dog number 8216 being so neurotic she was like she was in New Brunswick
at 1:00 AM - scared all the time. She said her heart raced all the time whenever she saw people
and was scared 24 hours a day! She said the best thing for her would be euthanasia. I asked if
she couldn't authorize that because she's the veterinarian and on the IACUC. She said she
couldn't. The best she could do would be to eliminate her from study, which she hoped, would
happen but it depended on the x-rays.

Lisa had moved the CCU into the surgery suite and when Terry saw it she said it was a. good
idea to have it in there as long as the inspector was there.

Terry said the inspector wasn't happy about the x-ray machine being in the surgery suite (where
it's always kept.) Rodney answered the inspector's questions about cleaning schedules and
asked him about the x-ray machine. Rodney told her we had cleaning logs and after she left he
said laughingly, a couple of times, "She doesn't know we ALWAYS keep the x-ray machine in
the surgery suite - she thought it was just in here today."

Rodney and Lisa told me they had told Terry the first dog they had x-rayed had been given an
injection of Xylazine and Acepromezine. The dog had a very bad reaction to it so they
anaesthetised the rest of the dogs with Ketamine and Acepromezine. Rodney said he knew an
approximate dosage of the ace/ketamine mix - 1 CC per k, but they didn't have dosage
calculations for it. They had dosage calc figured out for the xylazine/ace mixture but not
ketamine/ace. Rodney asked Terry what to do about it when the inspector was across the hall.
Terry said, "That's ok, can't you just quick write it out?"

Page 91.

Rodney said again he didn't know the exact dosage, just
what usually worked for him as a ballpark. Terry told him "Just put the
Ketamine/ Ace in your pocket and if the [USDA] inspector asks just tell her you're using
xylazine/ace and show her the calc you have." Rodney nodded knowingly and said he'd
wondered if he should do that as he placed the bottle of Ketamine/ Ace
in his breast pocket.

Terry left the room but turned and came right back saying to Rodney and Lisa "Just remember
when you falsify data use the same colour ink!" Everyone laughed and nodded.
Later, the inspector came in and when she walked through surgery she looked at the calc sheet
and the bottles of drugs on the table. Rodney stood next to her with the bottle of drugs they
were really using hidden in his pocket.

The USDA inspector found a primate with alopecia in P&G study 3221. Terry couldn't find where
she had recorded it during monthly physicals but she knew she'd seen it and recorded it. She
flipped wildly through the obs book that goes back to July but couldn't find the observation
noted. She even found Kevin in the cafeteria and asked him about it. Terry was so anxious to
find the data, Kevin said she spread the ob book out on the salad bar
for him to help her look.

He groaned about her even bringing the contaminated book into the cafeteria let alone laying it
on the salad bar. The inspector said the primate needed more enrichment because she was
self-mutilating out of boredom.

The inspector didn't like the way Lisa had her tracking records on the clipboards in the two
rooms for 3282. Apparently they're the same in both rooms and not separated by which dogs
are located in which room.

Lisa told me they'd come in to get the study file for 3282. I asked if she had a protocol for it yet.
She said there is only a draft protocol. I asked if there was a signed protocol for 3282. She said
no not yet. I said we shouldn't even have those dogs yet and she nodded. I asked if they would
see that (the inspector when she looked at the study file.) I said so they'll find out right, and she
shrugged saying "we aren't even supposed to keep the protocols in the study file, they just do
because it's easier". She said her study file was almost all empty anyway.
Terry told me again, she tried to refuse the shipment of dogs when they first arrived but Cathy
Kelly said no.

The dogs in study 3337 were killed yesterday and today. The hall was filled with the smell of
formaldehyde. I saw James - from necropsy, take a live puppy into the necropsy room where
four tables were being used. He plopped the dog on a table right across from another table
where a woman was using a big power saw to cut up the head of a mutilated dead beagle.
Behind James, another man shoved the bloody remains of another puppy into a garbage bag. I
think they should euphonise the dogs in a quiet room away from the sight of already mutilated
dogs. Study 3335 is being killed tomorrow.

Rodney said as we walked by necropsy "I wonder what the construction workers think when
they're here? What do they think of us and what we do? They must wonder what kind of people
work here. I shrugged and said they probably didn't think about it. He said he knows it's best
never to tell anyone what you do for a living. Never go into
details.

Page 92.

He said at his other job at the hospital, doing dog surgery research, when the inspectors came
they pointed things out to them in an effort to get improvements. He said one inspector was a
real jerk and cited him for haying a dog in too small of a cage. He said he better get rid of that
animal, he didn't want to see him when he came back in four days. Rodney said he asked what
he should do - he'd rather have him kill the dog or starve it just because of the cage. The
inspector had said I don't care what you do with it just get rid of it in four days. I asked Rodney
what he'd done and he said he really couldn't remember, he thought they'd found him another
cage.

He said they only had one room because it was academia and the inspector always cited them
for having multiple species in one room but couldn't ever come up with a reason. Why not,
because no diseases are transmittable.

Rodney told me while he worked at his other job, he sent his girlfriend a set of dog's eyes with a
note that said "I only have eyes for YOU." Then he told me he later sent her a dog's heart with a
note that said "My heart belongs to you."

3 /27/96 Thursday HLS

In study 3621 rat number 4001's eye really looks bad and no vet request has been written. Rat
number 1503 chewed the rest of the catheter tube out.

Irene, Yao and I collected dog bloods in 3623. One dog was acting squirmy when Yao was
holding the site off after collection and Yao slapped her in the head. Irene tied the catheters off,
cutting and knotting them before she forced them back into the partially healed incision site on
their backs.

I saw Kevin training Dilip to draw blood on a puppy from 3335. Dilip had to slide the needle in
and out of the dog's neck several times before finally getting the blood sample.
I watched a necropsy from the window. A puppy from 3335 was completely cut open from neck
to groin, his ribcage exposed. I saw the dog throw his head back and howl. I thought it was just
a final muscle convulsion after euthanasia, but then I saw the dog throw his head back writhing
from side to side still vocalizing. The last writhing head throw happened when the person doing
the necropsy sliced through the dog's leg muscles.

Irene told me they used to give the monkeys Ketaset and then slice them open all across their
chest and neck to find the vein so they could exsanguinate them. She said they had to start
giving them something else because basically the monkeys were awake they were just
completely paralysed - they knew what was going on they just couldn't
move.

Irene forgot to feed the DSI dogs until 2:30.

Irene told Brian about the USDA inspection and told him we got slammed on a lot of animal
welfare stuff.

Lisa showed me the vet physical list from 3282. She said usually there are maybe one or two
that have problems, her study had almost half of the dogs listed.

Page 93.

The DSI dogs are completely lonely and isolated. They've been warehoused with the implants
and no exercise for weeks.

James was very sad today when I went in to see him. He barely looked up from his foetal
position.

Cardio had practice rat surgeries today. Brian went to the table where Irene was implanting a
femoral catheter in a rat. He picked up a scissor in one hand and one of the rat's legs in the
other and said, "I think I'll cut his foot off." He started to close the scissors when Irene
screamed, "Brian! Don't you dare!" Brian laughed and said, "You know I'd do it." He didn't drop
the rat's leg.

Irene said, "I worry about you having children." Brian looked puzzled and asked her
why. Irene said again she really worried about him having children and said she hears about
people like him all the time. After that Brian dropped the rat's leg and walked away saying "It's
just a rat. No matter what PETA wants us to think, it's just a rat. It's not a dog or a goat or a
boy..." [Check video for verbatim - sound only - -no picture].

At came in to check on the surgeries and saw Brian cutting his rat's heart out. Brian always cuts
the rats wide open when he's done practicing and digs around until he finds the heart. He cuts it
out and puts it the operating table several inches away from the rat. The heart continues to beat
for several minutes as Brian pokes and prods and it and the rat. If anyone rolls their eyes or
says anything about it Brian always says very prou91y, "I'll never have nightmares about putting
a still-alive rat in the freezer.

I know they're dead when I get done with them - this is the only
way to really be sure." Al gave Brian a half- hearted admonishment and I said at least the rat
still has four feet to alert Al, who is higher up than Brian, about what Brian had intended to do
earlier. Brian said "Oh! That's right! I was going to cut his foot off." He picked up a scissors in
one hand and the rat's foot in the other and just before he could close the scissor Al said
"Brian!!" and stopped him. Brian giggled like a bad schoolboy caught chewing gum. Nothing
else was ever said about it.

Irene took the extras from her rat study 3621 for practice. One of the rats that had been
anaesthetised with isoflurane already had two catheters in and couldn't be used for practice.
Irene told Rodney to kill her. Rodney wrapped the rat in a paper towel saying he didn't like to
look and put her in a plastic bag. Then he pulled her head one way and
her body the other.

He
didn't spend more than a few seconds pulling at her. As he put the bag down I asked if he knew
if she was dead - how did he know for sure. He nodded knowingly and said, "She's dead."
About twenty minutes later I saw the rat trying clumsily to crawl out of the plastic bag. I
screamed for Rodney to come and look at the rat he had killed - she was still alive. He left the
rat he was operating on open on the table and as he walked across the room said, "No, she
can't be."

Putting her back in the plastic bag he grabbed her head in one hand and one leg in
the other and pulled and twisted. Then he put some isoflurane on a paper towel and dropped it
in the bag before tying it shut. Again, he didn't look for any vital signs before putting the rat
down and assuming she was dead.

As Yao was preparing to start surgery on his rat, the rat pulled his head from the anaesthetic
mask and started struggling on the table. It took several minutes of holding the rat's head in the
mask for him to become anaesthetised. When I had prepped Brian's rat, I gave it to him and told
him to wait a few minutes before starting because the rat was light after being carried from the
prep area. Brian immediately taped the rat's legs to the table and cut into him. The rat didn't
move but I saw his respiration increase dramatically - a well-known and reliable indicator of
pain.

Page 94

Rodney left the OR to use the bathroom. He had a rat cut wide open and still alive on the
table. About ten minutes later, Irene asked where he'd gone and when he was coming back.
Someone else finally killed the rat and Rodney drifted back into the OR more than twenty
minutes later.

One of the extra rats brought over for practice surgeries had a deformed, discoloured eye. It
may have been caused from improper bleeding. New techs use extra rats for practicing
procedures. That rat was still left at the end of the day and was taken back to the extra colony to
suffer for an indefinite period of time.

3/29/97 Saturday HLS

Rat number 4001 in study 3621 does not look well. His eye is still all bloody and scabbed over.
The open wound on his back where the end of the tied-off catheter still protrudes looks infected.
It's very raw looking and I can see green thick material down in the
opening. He is not very active, spending most of his time sitting at the back of his small cage. His coat looks very dirty
like he's stopped grooming himself. No one has filled out a vet request for him - it looks like he'll
just suffer with the pain until the study is finally over next week.

Rat number 4503 still has an open wound on her inner thigh. It looks like it's starting to close up
but it still looks swollen.

The DSI dogs were so hyper and needy today. I don't think anyone's given them any attention
since I cleaned the room on Thursday morning. 1190M and 1272M are so loving. As always
they're torn between running the length of the room and snuggling. Today when I opened their
cage doors they literally threw themselves at me and didn't want to be
put on the floor to run.

I spent several minutes rubbing their tummies and nuzzling their faces before they felt happy
enough to scamper around. 1190 always has such a worried look on his face. 1272 spends a lot
of time sitting on his haunches and he still keeps the weight off his left hind leg. I think his sciatic
nerve may have been injured during the surgery. Rodney told me that
happens sometimes.

Dog number 1367M loves to run but once I put him back in his cage he does everything he can
to keep me from closing the door. He tries jumping out at me, sticking his head and feet out of
the door and finally grabbing at my hands with his mouth as I push him back in so I can shut the
door. He's so frantic about grabbing my hands it breaks my heart. The little females, 1255 and
1264, are very loving and always press their noses into my neck. They're both very small and
thin, the DSI implants sewn under their skin look like big horrible tumours. Even when they're
running and playing and being hugged the few minutes I'm with them, none of these dogs ever
truly look happy. They always have a worried look in their eyes.

The five puppies in study 3623 are all in the recovery phase and are out of the jackets and
tethers. Today I hugged and talked softly to dog number 3750 for a long time and she wouldn't
even wag her tail. She hung limply in my arms as if it was too late to
try and comfort her.

In study 3282, the dogs are still very fearful. There are a few who don't cower in the corner of
their cage after the door is opened. These dogs act just crazy. It's like they have no idea how to
act. They've bought into the idea they don't have to be so afraid but now they don't know how to
act. They circle and jump and bob wildly all around the cage. When I reach for them they go
nuts - flailing wildly as they try to evade my grasp.

Page 95

When I finally get a hold of them, they freeze and dig
their feet into the floor grate, as if they suddenly remember they have reason to be
afraid. The dogs are so stiff, the heavy cage grate is pulled out of the cage with them.
Dog number 8181F had vomited mostly red bile. I saw in the ob book this is the third day there's
been blood pooled in the bottom of her cage. On Thursday it was attributed to faeces and on
Friday it was marked under vomit.

Todd, a new associate tech hired by Delta to do temporary work unloading the archive trailer,
told me the company has to archive everything it produces. They have material from the sixties
down in the basement and even if they go under they have to hire someone to work in the
archives. He said its FDA. He said Huntingdon's started calling companies and telling them they
have to start paying for storage if they want Huntingdon to keep the
data.

Todd said of course
they can't do that legally but they're hoping the companies will say go ahead and get rid of it.
Todd said he learned all about the archives the week he worked down there. He said that's
really all they did while they hauled boxes was talk to Henry about
it.

I heard George and Rachel talking about a monkey who'd gotten his arm stuck. It was swollen
but George got it free. Rachel was telling him he had to record it. She said it was ok this time
but he really should record it.

I went in to see James about 2:30. It was less than an hour since dosing and he was still all
freaked out. He was sitting tensely on the perch of his cage when I went in and he grinned
submissively and scampered back when I approached. He came to the front of his cage when I
knelt in front of it and stared out into the room. He let me stroke his leg for a while but while I
was petting his tummy one of the neighbouring monkeys started shaking his cage violently,
screaming and banging at the bars. All the noise startled James and he tucked down into his
foetal position. He didn't look at me at all today the few minutes I was
with him.

3/30/97 Sunday HLS

Rat number 4001 in study 3621 is a mess. His eyeball is completely dried out. His cage, face
and feet are covered with blood. The area around the mutilated eye is inflamed and looks
infected. His catheter site looks infected and full of purulent material. It looks like the centre of
the eyeball itself is starting to cave in - or maybe it's not as swollen as the rest of the eye
socket.

I asked Brian if we should fill out a vet request for the rat with the eye problem. Brian said "What
rat? I was just in there obbing and I didn't see anything." Then he laughed. I reminded him
about the rat, whom Irene and I had told Brian about on Thursday. He asked what group it was
in. I told him he was in group four.

Brian said he wasn't surprised he didn't see it then because
group four is on the bottom row. He said, "She [Irene] has the whole rack and she has to put all
of them on one side all the way down. She should use the first two rows on both sides to make
it easier to see them - for me anyway. Maybe the rest of you can see them but I can't." [Check
video for verbatim quote] Brian is very obese and is unable to perform any animal care tasks
which require him to bend down low. When he bleeds monkeys he only bleeds those in the top
row of cages and makes everyone else do the monkeys in the lower
cages.

We went to look at the rat and Brian agreed it didn't look good but he didn't think we should do
anything. He said we should leave it and make Irene deal with it
tomorrow.

Page 96

I told him we could at least fill the vet request out and have it ready for Terry, she probably wouldn't look at it until
tomorrow anyway. He said he didn't really know that much about rats and he would check with
the rodent tox people and see what they usually do. He said he didn't know if they usually write
up things like this.

I obbed the DSI dogs. Dog number 1367 threw up yellow bile while I was in the room.
The Magainin dogs in 3623 are very lonely.

I helped Brian do vet treatments in 3282. He obbed the rooms first. In 950, he wheeled the cart
of medicine in and filled out the ob book. He saw I had marked 8207 as having unformed stool
yesterday - I checked her cage and told him it was normal today. He checked WNL for all the
dogs without even walking the length of the room. He did not look in any of the cages before he
checked WNL.

He made several remarks about not treating any of the dogs with vet requests in 3282, saying
they didn't need it. I was in the room and he had me help him treat the dogs.
Brian told me the Colgate dogs that were used in the gingival study were as bad or worse than
the dogs in 3282. He said they never got any better and all the petting in the world wouldn't
make a difference with the bone dogs. He said the gingival dogs were transferred to the extra
colony, the Colgate extra colony and not sacrificed at the end of the study because they didn't
know if they wanted to use them in another study. He said they were
sacrificed after being in the extra colony for a long time.

Brian told me he doesn't like the way Gene preps dogs for surgery. He doesn't like that he cuts
open their skin before putting the abo-cath in. He doesn't think it's right, it's not SOP, and he
said it can't be very comfortable for the dogs - "...it's got to hurt like hell when he does that."
Brian also said he doesn't think it's good that Gene takes the abo-cath out right away instead of
taping it in.

I went in to see James today. He was clinging to the front of his cage and flashed me his
submissive grin before focusing in on me. He tucked his head down and let me rub his back. He
stretched his head back so I could rub his chest. I told him he was too far away from me and I
couldn't reach him. He got up and walked to the back of the cage. When he came back he
settled in as close to the cage door as he could get.

I rubbed his arms, legs and chest for a few
more minutes. James tipped his head back with his mouth open slightly as he stared vacantly at
the top of the cage. The distant expression on his face makes me think it's becoming harder for
him to know kindness for a few brief minutes than to never know it at
all.

I went to F-wing to see the rabbits. In room 550, there are rabbits with collars and shaved
patches. It's a U-10 study, Union Carbide study. In 952, the rabbits are not on test, in 954 there
are two different studies going on for Union Carbide. A couple of the rabbits had scabs in the
shaved area where the test material had been. In room 956, the rabbits are not on test yet.
The study file for 3282 has two forms authorizing animal orders for the study. One is dated
1/27/97 for 34 animals. Another is dated 2/12&14/97 for six animals. They are both signed by
about four people including the study director Cathy Kelly.

Page 97

The purchase invoice lists Harlan International in Indianapolis, Indiana as the supplier. The
tracking forms and canine histories list Ridglan Farms in Mt. Horeb, Wisconsin as the breeder.
The DSI husbandry record has a notation written across March 24th noting nothing was
documented for animals fed due to an oversight. On the schedule Rodney was responsible for
feeding them but nothing was documented for the 24th. On Wednesday and Thursday I asked
Irene, Brian and Yao if they knew if anyone had fed them. They all shrugged and said they were
sure they were fed and it just wasn't documented.

Mike, the security guard from Pinkerton told me he had noticed the thermometer in one of the
rooms for 3314 has been broken for two weeks. He said they have to record the temperatures
of the rooms on their rounds and he saw the thermometer had a double red
line. He said that

it's obviously broken and anyone who looked at it could see that. He said one day he went into
the tech room and told some of the people who were in there. He told me Dilip told him not to
worry about it. Mike told me when he pursued it, telling Dilip they could all get in a lot of trouble
and the study could be compromised because of it, Dilip cut him off and told him rudely not to
worry about it. He said Dilip went on to say he didn't even know if there were any thermometers
to replace the broken one. Mike said even after he told the technicians in the room about it, Dilip
being the only one who would respond to him, the same broken thermometer remained in the
room. He said every day it reads the same.

4/1/97 Tuesday HLS

I went in to pick up my check and asked Irene and Yao if the rat's eye in 3621 had fallen out.
Irene said not yet. Yao said right away "Rat number 4001 ", everyone knows what rat it is and
no one is doing anything for him. I asked if a vet request had been put in. Irene said no and that
she hadn't even been recording it and shrugged. She said they never even record eye injuries
from bleeding because they happen all the time and the rats live. I asked Irene the day I
discovered if the rat shouldn't be euthanased and I asked Brian on Sunday if we shouldn't
euthanase him. They both said no like it was a strange thing to ask
about.

Eleanor was talking to Irene and Rodney about an Eisai study that large animals has coming up
where 48 dogs will be IV dosed a large amount of test material over several minutes each day.
Because of the dosing requirements the dogs will be tied into slings for
dosing.

4/2/97 Wednesday HLS

Rat number 4001M's eye looks horrible. It's starting to dry out and cave in. The whole thing
looks like it's starting to get infected.

4/3/97 Thursday HLS

Lisa and some of the other cardio people were in the tech room at our desks. Brian was making
my schedule for the weekend and asked me how long I needed to clean some of the dog
rooms. I told him I needed at least 45 minutes for the puppy room, 3627, and at least an hour
for each room in 3282, the bone dogs. He laughed and said, "What do you do in there?? Why
does it take you so long??"

I told him I followed SOP, that I use unicide, I check the water
valves after AND I TAKE THE DOGS OUT OF THE CAGES!!" He and Lisa both laughed. Brian
said "Well, I take the dogs out of the cages sometimes."

Page 98

I gave him a disbelieving look and he said "Well... it's OK if they get a
little wet. They like it. It's good for them to have a bath once in a
while..."

4/5/97 Saturday HLS

On or about this date, Lisa left me a note about counting digits and telling me not to write up
sores on the dogs' faces. "Don't write up sores on face."

4/6/97 Sunday HLS

Neither of the primates in 3630 have enrichment mirrors, but they do have used Kong toys. I
haven't seen those in any of the cages for months. In December and January, everyone was
throwing them out every time they saw them. I was told it's because they can't be sanitized
properly after use.

I'm not sure what date this was, but one weekend Rachel told whoever was feeding the P and G
monkeys in 3314 that she'd cut up oranges for them for their PM ob treat. She said she felt bad
because they don't get an AM treat or cleaning treat because they have to be fasted, before
dosing they just get one peanut and for PM obs treat everyone's always in a hurry to get out at
the end of the day so all they get is peanuts - no one ever takes the
time to get them fruit.

At a meeting, Eleanor made a point of telling everyone in large animals the peanuts and raisins
are supposed to be used only when there's no fresh fruit available. When I randomly check the
enrichment records in the rooms, I see peanuts and raisins being used almost exclusively with
fruit being an exception. It's easier to treat the raisins and peanuts because they're kept in the
rooms and the fruit needs to be cut and brought into the room each
time.

I've seen a lot of primate rooms where the monkeys don't even eat their peanuts because
they're so tired of them.

4/9/97 Wednesday HLS

Gene and I talked about his trip to the United Kingdom. He told me about their safety
pharmacology methods. He shook his head when he told me about it saying they don't even
have SOP's. He said they have no regulatory agencies monitoring them. He said when they do
a safety pharm study they use Alpha Chloralose, an ether compound with no analgesic affect, to
anaesthetise the dogs.

He said they intubate them by using an electric cautery iron to cut
through the dog's neck to the trachea. He said, "Basically, they do a tracheotomy instead of just
intubating them." [By putting the endotracheal tube into their trachea through their mouths the
way we do.] Gene said when he questioned them about why they didn't just intubate them
instead of doing the tracheotomy they looked at him like Hmmmm! That's something to think
about!

He said they use the electric cautery iron to do cut downs all the time, even using it to
expose veins and organs on still alive, under- anaesthetised dogs. He said the idea behind safe
pharmacology is to monitor the animal's vital signs to get a normal baseline rate, then test
material is administered and the vital signs continue to be monitored and recorded to establish
the test material's affect on the animal and the animal's system.

Gene told me because the
anaesthetic they use is inadequate and has no analgesic affect, the dogs' heart rates and
respiration is abnormal with all these peaks and lows for long periods of time before stabilizing
enough to begin the experiment.

Page 99

I asked how it would be possible to know how the test material
was affecting the animal if they had abnormal rates to begin with. When I asked him this he
shrugged and said "Exactly! They can't. They can't distinguish what's a result of the trauma of
the procedure and what's a result of the test material. When they're questioned about it over
there, they're allowed to say things like 'Because of my vast experience with this I know that
such and such is a result of whatever...'

He went on to tell me I should see the reports they write
after studies. He said they're so vague they can't even be read. Everything is written like 'It
could well be that...' and, 'In my opinion such and such is normal and probably not a result of...'
He said they don't back up any statements or data with proof leaving it open to interpretation. I
asked if that didn't make everything worthless. Gene told me "It would here. We would never be
allowed to be so vague." [He's told me before we at least have to go through the motions of
finding some type of statistics to back up our findings.]

Gene said he asked them what they do if
they're not able to get the animal to stabilize and he was told, "We throw the dog away and get
another one." He told me while he was there someone aired a story about the lab. Someone
had brought in video equipment and gotten some video of some people hitting dogs and stuff
and that it was pretty bad. He said four people were terminated that could be identified in the
video and there were probably more coming. He told me he's going to make some suggestions
about their safety pharm program and they'll be sending someone over from the UK in a couple
of weeks to look at how we do things.

Gene told me Irene and he had done a safety pharm experiment on a dog the other day and
used Alpha Chloralose to see how it did work. He said they put the dog under with isoflurane
and gotten some data under those conditions and then switched to Alpha Chloralose. He said
the values shot way up right away and there were all sorts of peaks and' valleys in the data -
nothing was consistent.

Some of the techs were talking about a monkey with an extremely swollen arm and rolling their
eyes that Nick had obbed it as slightly swollen.

Brian told Terry as she walked though the tech room "Have fun lancing feet..." then he laughed
wickedly like he knew some secret about the veterinary care.

The cardio team is supposed to practice tubing pigs tomorrow. Brian asked Terry if we needed
to fast them first since they'd be anaesthetised and sacrificed after. Terry said we should because
it's difficult to do and it will be even harder if the pigs are vomiting while we do it. Rodney claims
he can intubate pigs. I couldn't help but think of the bloody tracheal tube pulled from the only
beagle he intubated a few weeks ago.

4/10/97 Thursday HLS

Only worked one hour.

4/12/97 Saturday HLS

In Proctor and Gamble study 3630, no one did PM obs on April 9th. No one signed for treats for
PM obs on April 4th and 9th. No one signed for AM treats on April 11th. In 3282, room 949, on
April 11th Yao did vet treatments. No one signed for treatment on the 11th. The last treatment
was the 10th and I signed for the 12th.

Page 100

Theresa told me Penny broke the dog's leg in study 3327. She said it was the first time Penny
had cleaned a room alone and she came running to Theresa to tell her to come and look at this
dog because she thought she broke his leg. Theresa looked at it and told her to tell Walter.
Walter and someone else went in to look at it. She said that's when the exercise cages were all
finally fixed.

I have a hard time believing a dog's leg bone could be broken completely in two
just by falling through the hole in the exercise cage. I think it could definitely be broken that way,
falling through and twisting especially if someone was trying to drag the dog out while the leg
was trapped - I'd be interested to know if it really happened when a cage door got slammed on
it. This is pure speculation, everyone has told me it happened in the exercise cage. Only Penny
would know for sure.

I asked Theresa how she managed to lift the big dogs in study 3323 out of and into the exercise
cages because she's not as tall as I am and I find it difficult. She told me sometimes she just
lets them run back to their cages from the exercise cage if her back is hurting. She told me
Dean Rodwell had people on a tour one day and they were looking at her as she let the dogs
run back to their cage.

Later, I looked through the window at her' and saw she was cleaning
3323 without taking the dogs from their cages. I saw her hosing out an occupied cage. She saw
me watching her and later made a point of telling me she'd gotten tired halfway through and quit
taking the dogs out.

Theresa told me about the first time she went in to clean the pigs, the new hairless pigs, just this
week. She asked me if I'd seen them today, laughed and told me they were all beat up, that
she'd really killed them when she cleaned. She said no one had told her they'd never been
handled and she didn't know how to clean the cages. She said she didn't know you weren't
supposed to let them out of their cages and when she tried to catch them to get them back in
they each freaked out and had run blindly into walls and cages getting
all scraped up and cut.

She said one has a swollen face and anther has a big cut on his face, the other one has all
kinds of scratches all over. She said afterwards she told Rachel about it and Rachel took her in
and showed her how to work with them. I looked through the window at the pigs and even from
outside the room I could see the cuts on two of the little pigs and the swelling on the darker
one's face.

As I was getting ready to leave, I saw Terry walk through the tech room and kidded her about
working Saturdays after the last time. (She ended up looking at several animals and complained
about just being there to catch up on her own work saying she was never coming in on a
weekend again.) She laughed and said I know. "You guys are all going to hate me. Yimmer just
asked me to look at an animal and I told him I couldn't."

Before I could ask her which animal and
what was wrong, she asked me about my schedule - what hours did I work here and what my
other job was like, expressing concern to me over the number of hours I worked. We visited for
a few more minutes and she went back to her office. She had come in to the tech room to get
coffee and didn't seem to be in a big rush to leave. I would have rather had her look at the sick
animal than to sympathize with me for several minutes about my life.

4/13/97 Sunday HLS

Cesair wrote a vet request for a primate in the extra colony. The primate has watery stool
almost continually and has for weeks and weeks, it would probably be safe to say months and
months but I haven't copied the obs book. I looked through it and saw the monkey has been
written up for watery stool dozens of time since last fall, even being treated for it once,
unsuccessfully.

Page 101

The sap's say emesis should be written up if it continues for more than three
consecutive days. When Cesair wrote it up, it had been going on for much longer than three
days.

I looked through the window of room 906, study 3346, and saw Penny cleaning the puppies?
cages without taking the puppies out first. She was bent down hosing out a cage with a dog in it.
Spraying a stream of water toward the back of the cage. When she saw me looking at her I was
just turning from the window and as I rounded the corner I heard the door open as she looked to
see who had been watching her.

When I went in to see James today he stared into my eyes and then down at his feet as I told
him goodbye. Most of the monkeys in 3314, including James, will be killed on Thursday and
Friday this week. They're scheduled for all kinds of blood work and ECG's as the study winds up
and I told him I may not be able to see him again. When I told him this he came to the centre of
the door and pressed his whole face against the cage staring at me. I stroked his cheek and
whispered goodbye and as I stood up and he moved back to his foetal position, it occurred to
me, too late, that he was pressing his face forward for a kiss.

Stephanie and Penny were talking about George and a monkey in 3314 who died on Monday.
Penny was saying George thought it was his fault the monkey had died and Stephanie said no,
it wasn't that. They didn't know why it had died. When I asked her about it she told me it was a
group three monkey and they have no idea why it died.

The necropsy didn't reveal anything and
Arpad had screwed up and rinsed the brain off or something before he should have. They didn't
know what the cause of death was they thought it could be meningitis or something.
The four dogs in Kevin's radioactive study are in metabolic cages at the
end of the room.

In study 3282:

Room 949:

8199 - fearful

8197 - hyper

8200 - very fearful and wooden

8198 - fearful

8194 - hyper

8195 - friendly

8193 - nervous

8191 - hyper

8189 - fearful/friendly with coaxing

8192 - very fearful, cowers

8190 - fearful

8187 - friendly

8185 - fearful, friendly with patience

8188 - friendly

8186 - fearful

8183 - fearful and wooden

8184 - fearful

8182 - friendly but unsure

8181 - fearful, reluctantly friendly

Page 102

Room 950:
8219 - friendly, hyper

8217 - friendly, submissive

8220 - fearful and wooden

8218 - friendly

8215 - hyper

8216 - extremely fearful

8210 - fearful

8209 - hyper

8207 - fearful

8208 - fearful, reluctantly friendly

8206 - friendly

8205 - fearful, hyper

8203 - fearful

8204 - fearful

8201 - fearful, wild when handled

8202 - fearful

I sent Mike Toth an e-mail telling him we're out of unicide, the disinfectant we're supposed to
clean the cages with. We've been out for over two weeks.

I sent Terry an e-mail telling her I filled out a vet request for another foot sore in 3282.

4/16/97 Wednesday HLS

The cardio team did surgery on several rats today to set up a DSI validation study - -practice.
Two of the rats Rodney operated on died before he was through with the surgery. The first time,
I asked him if his rat was breathing he said yes and continued to work. I told him I didn't think he
was.

He tried to resuscitate him by blowing in a syringe placed over his mouth but the rat was
already too far gone. His colour was extremely pale and he'd been dead for some time. Rodney
always thinks if he can see the heart beating everything's all right. The second rat died the
same way, he was operating, I bent over to look pointedly at the balloon indicating respiration
and he saw his rat had died. While he and I think Al was operating, Irene noticed the pump on
the anaesthesia machine was not working properly.

The rat on the right side of the table was
continually waking up and the anaesthesia adjusted as the rat was held down. While we waited
for a replacement pump and for Mike Toth to come in and replace it, Lisa had to physically hold
Rodney's rat down. The rat was sitting upright on the table, his hind feet taped down his tail
swinging wildly as he tried to escape. His abdomen was cut wide open exposing internal
organs.

Rodney continued to operate while Mike worked. While we waited I tried to move the
anaesthesia hook up from the prep room in but the pump was bolted on and immovable. I kept
asking Rodney and ?? Al if they wanted to move the rats into the prep room until the pump was
fixed. They wouldn't do it. At one point while Mike worked Rodney told him to make it fast. He
taped the rat's tail to the table while he worked because it was moving all over and Lisa couldn't
hold down the rat and the tail both.

Throughout the day, there were problems with the
anaesthesia machine and rats were under-anaesthetised one minute and dead later.
Al told us later, the tubing is precisely measured and controls the amount of gas the animals
get. Rodney and I both told him the tubing had been cut twice to replace the nose cone
apparatus.

Page 103

When I left, Al and Rodney were debating whether an inch or two of tubing would
affect the rats so dramatically. I asked Gene, Al, Lisa, Rodney, Yao and Irene who was
responsible for checking the equipment prior to surgery and no one answered me. In surgery,
Carol Allgate from the UK was in observing during the pump failure. Everyone in the room was
trying to pretend like there was no serious problem with the anaesthesia even as Lisa held
Rodney's rat down.

The pump in the prep room is bad, too, and the switch has to be jiggled just
right for it to keep running. I told Al, Irene, Gene, Rodney and Brian about it but no one seemed
to acknowledge it. Yao eventually fixed the pump on his own - I don't know what he did or what
knowledge he has to do so but no one else ever looked at it as far as I know. [I don't remember
when Yao fixed the pump if it was over the weekend, that day, or the
next day.]

The dogs in the bone study were moved into dose groups and there is finally a signed protocol.
Lisa told me she was putting the standard memo into the study file - the one they always put in
explaining dogs were ordered without a signed protocol. The vague wording of the memo
dances around the deviation with wording like before distribution of a final protocol, or
something like that [check memo at office].

At lunch Al told me I've broken SOP's twice today, once by bringing soda into room 955 when
we had our meeting and by wearing a grey lab coat to the lunchroom. I didn't hear anyone
mention SOP's when the rats were crawling disembowelled off the operating table.
I saw Lisa clean study 3627 without removing the dogs from the
cages.

When I told Gene I was having trouble knowing how to do things because a lot of people didn't
do things according to SOP - and protocol and as I've mentioned to him before different people
tell me different things. He told me to always go by the rules unless that's not what everyone
else is doing and it would disrupt things to do it the right way. I told Gene I didn't understand
GLP.

I told him that it was hard for me to reconcile the fact that everyone spends hours every
day scrutinizing husbandry records for, i.e., eights that don't look enough like an eight to the
person reviewing, I told him I had to clarify a check-mark over the week-end - someone had me
re-write a checkmark because my straight stroke down extended just past my short stroke
upward and I had to footnote it and re-write the checkmark and all this is going on while people
aren't even bothering to take the dogs out of the cages when they clean. Gene responded by
saying he didn't know that was going on and he could see what I mean that animal care should
be at least as important as the paperwork. When I looked at him and raised my eyebrows he
hurriedly said or maybe even more important.

Gene told me he knew what I meant about things not getting done right. He complained to me
that just the other day he had asked some of the cardio team to make sure there was enough
oxygen in the surgical suite. He was told there was. Later, they had an animal on the operating
table and the oxygen ran out. There wasn't a spare tank in the suite and Gene had to run to
receiving to get another one. He said the tanks weren't brought to where they are normally kept
so just finding one took a long time.

Gene says we'll use a primate from the extra colony for practice on Friday. He told us "There's a
monkey Terry wants euthanased because he's sick so we'll save him until Friday so we can
hack him up a little." He said we're doing the DSI rat validation just to show the UK visitor, Carol
Allgate. He said we will use the DSI dogs for safety pharm - we'll administer things to alter their
blood pressure and heart rate and monitor them, then we'll sacrifice them.

Page 104

A primate in 3221 got out and was chewed up by some of the other monkeys. He has a huge on
his arm and his hand. He pulled his stitches out the day after
surgery.

Lisa asked me if I was quitting. I told her I was thinking about it and told her exactly what I had
told Gene that morning that people weren't even taking dogs out of the cages when they
cleaned while I was re-writing check-marks. Lisa laughed and told me she
knew.

I walked by room 949, study 3282 and saw Lisa cleaning the dogs' cages with them still inside.
She saw me watching her and when I went into the room 15 seconds later with the camera
running she was trying to drag a damp frightened dog from the back of her cage. I was
surprised to see Lisa cleaning this room, in particular, without taking the dogs out because she
always tells me she spends time touching each of the dogs whenever she goes into ob or feed
or whatever. It seems to me that spraying a hose all over and under an already freaked out dog
would undo all that touching and reassuring.

I saw the sacrifice order on the door of the Proctor and Gamble study. There are eight monkeys
that will be kept alive for a recovery period. Four of the control animals and four of the group five
animals - two of each group from each room. James is scheduled to die on Friday.
Stephanie was bringing the monkeys to the necropsy room and checking their numbers off the
sacrifice order as they died. Throughout the day I saw her carrying sedated primates wrapped
like sleeping babies in garbage bags down the hall to the necropsy
room.

In the afternoon I had a chance to go in and ask if I could observe. I saw the primate they were
killing, number 1071, had a lot of cuts and sores on his legs - I've seen cuts like that many times
after extensive and frequent blood letting and these primates had been having TK bloods for the
past 24 hours. I asked the necropsy staff if you needed a degree to work in that department.
The necropser told me no, sometimes they get people right out of high school.
Stephanie and one of the necropsy guys were trying to find a vein to inject something into a
group one primate. I could see the primate's hand clenching and
unclenching as they searched.

Stephanie was holding off and the necropser was injecting. In the past, I've seen the necropsers
hack a big chunk of skin off a monkey's arm to expose the vein. The necropser injected part of
the substance into the monkey before he realized it wasn't going in, it was just blowing up under
the skin. They switched arms and tried again, finally getting the solution administered. Just a
few seconds after that the necropser tapped on the primate's eye and asked if he was dead
before walking away. He left the room and Rich came in to do the necropsy complaining that
Henning was supposed to be in there doing it and he didn't know he had to come down to do
this until a few minutes ago.

He tapped on the primate's half-closed eyes with the end of the
scalpel saying "You dead?" before slicing into him. He completely opened the thoracic cavity
and severed an artery (vein??), saw the blood being pumped out by the heart said "you could
be more out - sorry" as he continued to slice and hack. He handed the guts to Dr. Bolte who
had come in just to examine and take samples from them. They told me they'd found intestinal
parasites in about half of the primates (check video for exact verbatim and numbers) they called
the parasites flukes and I asked if they were liver flukes. No one answered me but they told me
they had found mostly eggs in the intestines and one adult worm. I asked how that could
happen because the animals are routinely wormed during the quarantine period when they
arrive.

Page 105

Stephanie told me later she was told the monkeys came from some foreign country and if
they were heavily infested it would be hard to get rid of all of the parasites. When Rich took the
monkey's eyes out he asked Valerie who was labelling the tissues if they were keeping right
and left separate. She told him they hadn't been and he made a joke about not doing that since
1960.

Rich and Dr. Bolte tossed body parts onto paper towels and trays as Valerie labelled them.
Before long the primate was nothing more than a bloody flat mass, quickly scooped up and
tossed into the garbage can at the end of the table as Stephanie poked her head in asking if
they were ready for another one.

I made myself go in and talk to James one last time. I didn't want to - I walked by all the empty
cages with their doors hanging open in the next room, the former occupants now in bloody bags
in the freezer down the hall. My little friend looked at me and stretched out so I could rub his
stomach one last time and quickly slouched over into his foetal position when I said good-bye.
In 3627 one of the dogs broke a toenail. There was blood all over the
cage and the dog.

4/19/97 Saturday HLS

I walked by the Proctor and Gamble rooms, empty except for the eight recovery animals. James
is dead.

Yao told me they didn't use the primate from the extra colony for practice surgery. There wasn't
any time. I asked if the primate had been euthanased. He told me he didn't know and shrugged.
I went into the extra colony and was relieved to see the sick monkey. I was not there and his
cage was empty.

When I went in to 3627 and 3628 to dump the puppies' food and ob them I was surprised to find
almost all of the bowls empty. The puppies in these two rooms are being scoop fed, an
approximate 400 grams is scooped out and given to them - everyone knows about what 400
grams looks like in the containers we scoop with. Normally, there is a lot of food to dump out -
some of the puppies eat all of their food someday and just part of it
someday.

It varies, and
even though some of the bowls are usually empty there is always a lot of food to dump out.
When I saw all the empty bowls I checked the husbandry chart to see if Irene had remembered
to feed them. She signed for feeding. In study 3627 I put a handful of food in one of the puppy?s
bowls and he gobbled it up as if he hadn't eaten for days. I asked Dilip if he had gone in and
dumped the room and told him what the situation was. He said right away
she didn't feed them.

I tried to reach Irene, but her phone number was not available, I couldn't get it through
information. I left a message for Eleanor at home to call me with Irene's number and never
heard from her - no response it all, even after the fact, to see if everything had turned out all
right.

I stayed for an extra 45 minutes after I was done with my work hoping Eleanor would call with
Irene's number. I went back into the 3628 and noticed there was a little
spilled food on the floor.

Page 106

I had cleaned the room prior to feeding so I knew Irene had fed the dogs. She had probably just
used her own method of feeding - she has told me several times she doesn't' feed the fat dogs
as much as she should. She only gives them about half the amount we're supposed to. I
imagine she has the same feeding rule for puppies - feed them less because we always dump a
lot out after.

I dosed with Irene in 3282. The capsules are really big and they often get caught in the dogs'
throats. Irene showed me how to drag them to the waterspout and put a little water in their
mouth and hold their mouth closed so they have to swallow.

It's really hard for me to drag these scared dogs forward and shove the capsule down their
throat. I've spent so much time cleaning these rooms and trying to reassure them it violates
every sense of trust I've tried to establish. Often when I'm in the rooms I wonder if it's the right
thing to try and go slowly with them so they aren't afraid. I always tell them their smart to be
afraid -that people will hurt them here.

4/23/97 Wednesday HLS

I asked Irene if she fed the two rooms of puppies on Sunday. She said of course she had. I told
her about all of the empty bowls - that there was hardly anything at all to dump. She just smiled
at me and I asked her if she had used her own 'fat-dog' method of feeding, giving less food to
the puppies because there's often so much waste. She laughed and said, "You know me too
well, you know all my secrets."

It made me feel bad to think the puppies weren't given enough to eat. They're scheduled to
have femoral catheters surgically implanted yesterday and today, why not at least give them the
correct amount of food.

Yao and I did most of the prep work. Gene intubated the first two or three dogs and Yao did the
rest. They were given propofil IV in their front leg via a butterfly. Yao had a hard time finding the
veins on almost all of the dogs. Lisa tried to talk him through the procedure a couple of times.
Most of the time, Yao just fished around until he hit the vein and got blood back. At least one of
the dogs had to be masked down because he couldn't find a vein.

Al and Brian did most of the surgeries today. Yesterday Yao and Irene did most of them.
Someone from QA came in to watch.

Irene came in the prep room and told Gene Rodney was removing the endotracheal tube from
the dog by just pulling the balloon off, popping the cuff, instead of deflating the cuff with the
syringe. Irene said I thought we were supposed to save the tubes and reuse them - he did that
all day yesterday too. Gene said, "Ya know - I just asked him where all the tubes were from
yesterday and he said he didn't know."

This and the oxygen tank incident last week are just two more examples of how commonplace it
is for people at HLS to lie and say they've been doing something when they haven't or don't
know something when they obviously do.

Page 107

When I walked by the room where the puppies are after surgery, all in jackets and attached to
big machines, I could hear them whining and crying. When I went in I saw the last puppy
operated on was sitting shaking at the front of his cage saliva hanging
from his mouth.

4/24/97 Thursday HLS

Rodney asked Irene if he could help take the pre-test bloods in 3627. He told her he knew how
to do it. When she told me I laughed and asked if she believed him - that he knew how. She
said she did. I held dogs for Rodney and knew right away if he did know how he hadn't done it
for some time, and he had never used the spaz tubes (vacuum tubes).

He fished around and around inside the dog's neck and when he did manage to hit the vein, the
blood didn't go in the collection tube because he had 'blown the tube' before he even started.
Pushing the needle into the vacuum tube before it's inside the skin causes is to lose the
vacuum.

He went through at least five tubes each time sliding the needle all around inside the
dog's neck. Twice the dog got huge haematomas immediately because he went through the
vein and blood gushed out under the skin. Finally, he asked Irene to bleed that dog and she
instructed him how not to blow the tubes. He complained that the dogs' having the jackets and
foam collars on made it hard to find the right spot. He tried another dog and finally jumped at the
chance to leave the room and help someone else with something. Lisa and Irene finished
bleeding the dogs.

After he left the room, Irene told me and then Lisa and Yao that Rodney had obviously never
used spaz tubes before. She said she could see right away that he didn't know the first thing
about taking blood this way.

Rodney says he has a lot of surgical experience on larger dogs and says he used to work in an
animal emergency clinic where he did things like suture animals after trauma and euthanase
animals. He is a frightening person to work with because he's overly confident about what he
can do and rarely admits he doesn't know how to do something. He jumps in and just does it
trying to fake it. It's very hard to put a trusting vulnerable little animal on the table in front of him
and watch him struggle to pass himself off as an expert at the animal's
expense.

4/26/97 Saturday HLS

The larger of the two cages used for dogs measures 39 inches deep, 45 inches across, and
353/4 inches tall. The smaller of the two cages used for dogs measures 36 inches dt1ep, 36
inches wide and 32 inches tall. Normally, a mix of the two cages are used. People just pull
whatever cage is closest to the front of the room, however, there are a couple of technicians
that try to only pull the larger cages for their studies - if, they're
available.

In room 955 where Gene has been doing safety pharmacology, I found two full bottles and one
partially full bottle of Alpha Chloralose. This is probably the same stuff Gene used to duplicate
the UK safety pharm program. The bottles looked extremely old - -the labels were slightly
yellowed. There wasn't an expiration date on the bottle but it was labelled like test material is.
The receipt date was 12/28/93, the company code was S-13, and the manufacturer was Fisher
Scientific.

Page 108

In this room I also saw a gallon of Hibiclens with an expiration date that had past. It looked like
the same gallon of Hibiclens I gave him a few months ago to dispose of because it was expired.
The bottle was wrapped in plastic just as this one was. I've never seen any other bottles
wrapped that way. I always just give the expired supplies and drugs to Gene because pharmacy
doesn't want them to be returned there as the sheet I record them on says. I wonder how many
other expired drugs and products Gene just reuses in other discreet
venues.

Around 11:30 Todd told me he still had three dog rooms left to clean and he'd probably be done
by 12:15 or so. He only had to wait for Lynn to ob one of them after twelve before he could start.
I asked how in the world he could get done so quickly. I told him it takes me at least 45 minutes
to an hour to clean each room. He told me "On the weekends when I clean I don't take the dogs
out of the cages."

He said "During the week when there are people around, you bet I do then - I
do a good job and go by the rules but on the weekends - forget it! I can be in and out of a room
in about 10, 15 minutes - less if there's nothing on the grill. If there's stuff on the grill than I have
to open the cage and hold the dog on one side while I spray it off. Otherwise it's just hosing the
pan out."

He told me he hates cleaning 3282, Lisa's study [the bone dogs.] He told me he got bit in the
second room once when he was cleaning. He took the first female on the lower left out and
while he was carrying her to the exercise cage she chomped his hand. He said he dropped her
fast when that happened - threw her on the ground swearing and when he picked her back up
to get her in the cage he just threw her in by the scruff. He told Eleanor he didn't want to be put
on the schedule to clean those rooms anymore. She told him with scheduling problems she
couldn't promise not to put him on, he'd probably end up cleaning in
there anyway.

He said
Eleanor told him "Just don't take the dogs out of the cage when you clean." He looked at me
and smiled and nodded and said, "So that's what I do! I just don't take the dogs out of the cages
when I have to clean in there." He said when he first started [last month], he always took his
time and stretched his schedule out, milking it for all the time he could get but days like today he
just wants to get out of here.

He told me he heard Eleanor has gone as far as she can go in this company. He said being
group leader was the highest position she can get. I asked if it was because she doesn't have a
college degree or something. He laughed and told me "It's because she just has a GED." I said
"You're kidding?" and he said, "Nope, Eleanor just has a GED."

There is a hand written sign on the door of room 950 to watch out for 1787, the dog who bites.
Lisa told me last week to watch out for her if I have to dose her because she snaps. She said
someone must have done something to her because she just started doing that - she didn't
when she first came.

I've known since I started that most of the employees don't remove the animals from their cages
when they clean. Some people try to hide it and some people are blatant about it. On the
weekends, especially, animals are rarely removed from their cages prior to cleaning. There has
been this accepted thought that technicians are too good to clean cages and it's acceptable for
them not to waste a lot of time doing it. When Dean Rodwell stepped in and authorized more
associate technicians to be hired so there would be a "dedicated animal care staff," to solely
take care of animal husbandry, I assumed they would be dedicated to
animal care.

I guess the
term means their time is dedicated to animal care as opposed to other tasks because the
dedication I've seen includes, Todd, Theresa and Penny not removing animals from the cages
when they clean, Theresa injuring and then laughing about injuring the pigs during cleaning and
Penny breaking a dog's leg.

Page 109

Todd boasts about handling the frightened bone-dogs improperly to
keep from being bitten.

Todd also talked to me about the dogs in study 3282 and what's in store for them in a few
weeks. [The dogs' front leg will be broken and put in a splint]. He talked about how bad they'd
be to work with after that, saying, "They're bad enough now, can you imagine what they'll be like
after that?" Then he said "They should just break all of their legs so they'll be easier to work
with." He joked about how great it would be to move them from to cage to cage if all of their legs
were broken.

4/27/97 Sunday HLS

Yao and I did food consumption in 3282. When Yao put the food bowls back in the cages he did
not put them back in order. All of the dogs got another dog's bowl put back in their cage. I've
been told by Kevin and Kathy that they should always only get their own bowl back because
saliva could contain test material and alter the study.

4/30/97 Wednesday HLS

Gene sent me an e-mail telling me the DSI validation calls for values to be taken from the dogs
as they are killed but the validation [protocol?] only calls for four dogs to be used and they have
five set up and he'd see what he could do. He followed with another e-mail telling me it was
against USDA regulations. When we spoke later he apologized and said USDA didn't allow
animals to leave the facility. I asked if it was a liability thing.

He told me it was from the USDA
and just part of their regulations. I asked if it was federal then - a federal regulation that animals
couldn't leave the facility to be adopted out. He told me it was. Later, he sent Terry Kusznir in to
talk to me about the dog I wanted. She told me it was all PET A's fault and all those other
animal rights groups. She said way back [in the sixties?] when the animal welfare act was
established PETA said OK, you can't use pets for research and in response the research
community said OK, you can't use research animals as pets.

She said it was designed to foster
a perception that research animals are a different species than animals people have as pets
she said they [the research community] want people to recognize a dog used for research as a
completely different species than, say, the German Shepherd you have at home." Brian was in
the room with us and he asked her if pets are never used for research anywhere. She said you
used to be able to go down to the local pound and get any dog or whatever and use for
research but now you can't after the animal welfare act.

I asked her if it was federal or state, and
did she mean that pets are never used for research. She said not in New Jersey maybe still in
some places but she didn't know exactly what states. She said she was sorry but she
emphasized again that they want people to recognize animals used for research as different
species than animals kept as pets.

Irene told me they've had to repair four of the catheters in the Magainin catheter dogs for study
3627. She said the catheter material they used this time is very stiff and has "memory" if it gets
twisted or kinked at all it stays twisted and the doesn't allow the saline or eventually the test
material to flow through. If there's blood in the catheter it clots up easily when the test material
isn't flowing through. Gene ordered this material because it's
cheaper.

Page 110

It's been one week since the twenty puppies were operated on. Normally, the dogs are given a
one-week recovery period after surgery then the dosing starts. Irene told me the dosing isn't
scheduled until next week, making it two weeks since the surgeries. With all the problems the
catheter material is creating, she's worried about how many dogs will still have functional
catheters when dosing begins. Because they've had to surgically repair so many catheters,
everyone is behind on starting the next Magainin study 3628.

This study also will use 20
puppies with surgically implanted catheters. Surgeries are scheduled for May 1st and 2nd.
When Gene asked Irene how things were looking for surgeries tomorrow Irene told him "We're
really behind because we've spent so much time repairing the catheters in 3627. Gene nodded
and told her to do the best we could.

At the end of the day Gene told Irene, Rodney, Lisa and I he wanted to warn us that dosing for
the two Magainin studies 3627 and 3628 may be delayed as long as two weeks because they're
having trouble getting enough test material. Meanwhile there are 20 puppies already suffering
with catheters, jackets and tethers - many having to be re- operated on to repair them, and 20
more scheduled to be operated on tomorrow and Friday. The dosing for 3627 is just a 24 hour
dose and for 3628 it's a 120 hour /5 day dose.

After dosing is completed the jackets are
removed and the catheters tied off. Because there is no test material for dosing the dogs will
suffer, possibly weeks longer, with the uncomfortable jackets and tethers. There is no provision
in the protocol for this and an amendment will probably have to be added to the study file. I
would think IACUC approval would be altered by the extended time frame, however, Irene told
Rodney there is no limit to the amount of time the dogs can be hooked up
to the pumps.

The schedule for study 3627 and 3628 were changed back and forth several times over the last
few weeks because the sponsor didn't think they would have enough test material. It appears
they decided to keep the original time frame knowing they wouldn't have the test material.
Terry conducted a meeting about procurement and receipt of animals. She mentioned many
ways in which HLS is deficient. She said the extra rodent room breaks AALAC rules and we get
written up for it all the time. Both mice and rats are kept in the same room in the extra colony
even though she's told them [decision makers at HLS] they need to be
separated.

She said they
tell her there's no room. The extra rodent colony is in C-wing. I've been in that wing several
times in the last seven months and have never seen animals in any of the other rooms in C-wing.
At least one of the rooms across the hall is used for cage storage only. I think most of the
rooms are just used for storage.

She reprimanded Brian about making a joke about picking animals up off the street when she
asked what procurement means. She asked how many people had heard about the video from
England. Saying "OK, some of you have, some of you haven't. If there were a video recorder in
this room, all PET A would need to do is take an excerpt of what you just said and sell it to Hard
Copy or Current Affair and it would make not only us look bad but all research would look bad.
Even though you're joking you can't go around saying stuff like that. We could all get in trouble."
Terry said rabbits and guinea pigs should not even be kept in the same wing because of
disease transmission but that's just the way we do it here and again she's been told that's just
how it is when she's recommended changes.

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She mentioned a dog stuck his head out of his cage in the hall during cage changing 0-
yesterday and got hit by a cage being pulled by. She said his tooth got broken and that is an
example of an injury, which could lead to a secondary infection.

During cage changes, dogs are transferred to clean cages in the hallway, then their dirty cages
are pulled by them. The hallways are very narrow and when the dirty cages are pulled by the
clean cages containing dogs they barely clear the occupied cages. Often the dirty cage gets
stuck between occupied cages and the wall and they have to be tugged and pulled, usually
dragging the occupied cage with them when they're pulled free.

Dogs routinely stick their heads
out of the feed bowl holes and look up and down the hall. If a cage is dragged by while the
dog's head is outside the cage it's inevitable injury will result. Everyone hates cage changes and
try to get through it as quickly as possible. The object is to get the cage pulled to cage wash as
quickly as possible and I've never seen anyone take the time to lock bowls into all of the bowl
holders to prevent the dogs from injury during cage changes. I've never seen anyone look
behind them as they pull to make sure none of the dogs' heads or other body parts will get
caught when the cages roll by.

Mahsa told me once when I started "The hallways are too narrow for this. It's very dangerous."
They really should do this a different way so the dirty cages aren't pulled by another row of
cages in the hallway. It would be very simple and only slightly more time consuming and labour
intensive to pull the clean cages to a section of hallway where the dirty cages would not have to
directly pass them. It would entail carrying the dogs further down the hall to put them in a clean
cage and then pulling the occupied cages a longer distance.

A small price to pay to ensure the
safety of the animals. This system would really be easier because the hall is so narrow the
cages bounce off the other cages and the wall and get stuck so much it takes extra, frustrating
pulling and tugging to navigate the passageway. I have horrible visions of dogs getting their
heads crushed between cages every time I pull a cage down the hull.

Terry talked about the difference stress makes on blood values if an animal is bled when
stressed.

5/7/97 Wednesday HLS

Irene told me yesterday was a day from hell. She and Al had to do surgeries on nine monkeys
for Proctor and Gamble, putting telemetry devices in their uteri. They aren't done yet, they have
more monkeys left to operate on. She said, "I've never even done it before and I had no idea
what I was doing. I don't know why they had me in there doing it. And then we had to work
straight through we didn't even get a lunch [break]."

I remember when Al operated on the
monkey for the pilot study Irene wasn't even in the room - she said she looked in once and it
was too crowded so she didn't come in. The reason they had to set up the monkey for the pilot
study was so they could find out if they could even do it - if they could implant a telemetry
device into the monkey's uterus and monitor uterine contractions.

She told me she had trouble with one of the surgeries. She couldn't find the vein she needed
and had to go to the other leg. Then when they checked the ECG reading from the telemetry
implant they told her she was supposed to have left one of the leads on that other side anyway,
the one she'd closed up. She told me you should just see her she has so many scars and
stitches she's a real mess. She told me they were so busy they had to work straight through
without a lunch break.

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She said a lot of stuff got missed yesterday because we were so busy.
Lisa's dogs didn't get fed till late. Brian had put her on the schedule to feed them at 2:00. But,
she was in surgery until four and got out and realized she should have fed them. They had to
put a memo in the study file that they'd been fed late and food consumption would still be done
at the same time. She said Rodney missed a bunch of stuff on his schedule. [Which is nothing
new. He was hired as a technologist. He missed AM obs in Lisa's study on the 5th. He was
supposed to feed DSI dogs and didn't a few weeks, ago - the memo reads inadvertently not
documented or something.].

She said they had that going on, there were catheters to repair in both her Magainin study 97-
3627 and Al's Magainin study 97-3628. She said they were so busy with all these studies and
so short staffed all kinds of stuff has been getting missed. She said the rats arrived - for Yao's
Magainin study 97 -3625 and Rodney's Cephalon rat study - Rodney's study calls for rats to
have jugular catheters implanted and at some point in the study, blood samples will be taken
from the catheter and they will be transfused with blood from extra rats from the same study -
ordered just for this transfusion - they'll be anaesthetised with C02
and drained of blood.

She told me people were coming from Ethicon to surgically implant six pigs with a mesh used for
hernia repair. She also told me her dogs in 97-3627 were starting a 24 hour infusion dose today. Al's dogs in 97-
3628 would need to be sorted into dose groups and hopefully we wouldn't have any catheters to
repair.

Irene told me there was one monkey in 97-3630 who was still all hunched over and none of
them had really eaten anything. She said they didn't even eat their raisins, which was really
unusual because they love those and always eat them right up. She didn't write a vet request or
ob it in the viability book.

When I went in to clean the monkey room I saw she had already done it. Earlier, when I went in
just to look at them, I noticed two of the monkeys had blood in their cages. 7107F, in particular,
had a lot of blood pooled in the back of her cage. The primate to her left had several bright red
drops of blood in her cage, in the pan and on the flooring. I saw in the obs book Irene had
marked them all WNL. I think she may have hosed out the cages so I wouldn't see the blood
and check the ob book, not knowing I had already seen it.

In the tech room, I heard her tell Al none of the monkeys had gotten their shot of analgesic after
surgery yesterday. He nodded and she added, "It's in the protocol, too." I asked her if we should
go give them the analgesic now - do we need to go give them their shots? She said no, it's too
late now. They all look fine, they're climbing up on their cages when you look at them and
there's only one who still looks hunched over.

I recognized one of the monkeys right away when I went in. Number 7028F was in 96-3314, the
Proctor and Gamble NG study that just finished - it still has eight animals in recovery but all the
others have been euthanased. She was an extra, and stayed in the room throughout the dosing,
massive bloods and ECG's. She had chronic diarrhoea throughout most of the study.
Something that may have been cleared up after they found the flukes during necropsy. Another
monkey, 7107, is extremely fat, she looks familiar to me I think she was
in 3314 as well.

Page 113

Irene and I went in to ear-tag the puppies in 97-3628. They already have pre-test ear-tags in but
the numbers change when they go on-test. There were about ten of the 16 puppies left to ear-tag.
She doesn't like to use the ear-tagger because she always ends up - breaking her artificial
fingernails when she closes it on the puppy?s ears so she asked me to do it. When we ear-tagged
97-3623, she had me ear-tag the four puppies in that study, too, for the
same reason.

The old ear-tags are removed by using a dog nail clipper to cut off the stem of the ear-tag that
the numbered tab slides through. She didn't bring the nail- clipper into the room to remove the
existing tags saying we used the big pink- handled scissor yesterday and that seemed to work
just fine. I held my breath when she put both hands on the scissor handle to close it on the hard
plastic ear-tag. The puppies' ears are so floppy and mobile, I couldn't believe she didn't
inadvertently slice through one of them. She had a hard time cutting through the ear-tags on the
third dog - eventually trying to just randomly snip off hunks of
plastic.

She tried to just manually
yank it through even though it wasn't' properly cut off - enough of the wide stem remained so it
wouldn't slide through the other part of the tag easily nor would it slide through the bloody hole
in the dog's ear. When she tried prying it off and pulling at it, the puppy cried and screamed.
She eventually got the tag off and when she had the exact same problem with the next dog's
tag I ran to get the proper tool for her to use. When the other ear tag was removed the large
round hole in the dog's ear was exposed and they all looked sore, raw and bloody. Some of the
holes looked infected. I tried to line up the new tag with the existing hole but on dogs Irene had
struggled to cut the tag off, there was so much blood it was hard to see
where the hole was.

All of the puppies jumped and pulled back when the tag was put on, some of them screamed.
Because they're attached to the tethers and have jackets and foam collars on, the dogs can't
even shake their heads after the ear-tag is pushed through. They can't rub their sore ear with a
foot or shake the pain away. All they can do is jump wildly in a tangled circle as the pain burns
through.

One of the dogs had a severed catheter line by the time we got to him. Irene said it's a good
thing we had to finish ear-tagging this afternoon - if we hadn't that dog could have either bled to
death overnight or his catheter wouldn't have been usable by the time we found him, it would
have clotted up. The puppy's tether was swinging from the infusion pump and his jacket was
soaked with blood. There was blood pooled in the bottom of his cage and splattered all around
it.

She spliced a new catheter line to the three inches of bloody tubing hanging out of his back.
She told me to put the dog in the sink while she got the new jacket and tether ready. Yao came
in to help get the dog put into his new jacket. I used hydrogen peroxide to clean the clotted
blood off the dog's side and back.

Yao held the rest of the dogs while I ear-tagged. When I tried to take my time arid line up the
new tag with the existing hole he said "Yeah, yeah, is good, go ahead. That's fine." From where
he was standing on the other side of the dog I know he couldn't see the existing hole or the tag.
Once, the wide male stem didn't connect with the female part of the tag after it was in the dog's
ear.

Yao tried to yank the stemmed part of the tag back out through the hole in the dog' ear. The
dog screamed in pain - the wide plug on the end of the tag is broader at the bottom and there's
no way it could humanely go back through the hole in the ear. Yao continued to pull at it and I
had to push his hand out of the way so I could cut the tag off and try again. A couple of times, I
could feel wet drop hitting my arms from the blood and tissue as the tag
cut through the ear.

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I checked the memos in the study file for 97-3627. On the morning of 4/24/97 dog 8283M had a
positional problem with the catheter, which had to be surgically corrected. On the morning of
4/25/97 8295F had a severed catheter line. The morning of 4/29/97 8299F , 8300F, 8302F and
?? all had to have their catheters surgically corrected.

Brian complained to me about how hectic the schedule is and how we don't have enough
people to do the work. He told me about the primate surgery for P&G saying, "Frankly, I didn't
even read the protocol before the surgeries...".

Chemical analysis didn't have the IV dose bags ready until around 4:00. The dosing was
supposed to start around 12:00. Michael from QA came to audit dosing. I stayed to help Irene,
we were stagger dosing them - starting the infusion on each dog 5 minutes apart so when the
dose stops we would have time to do the post dose ECG. Irene started the first bag and I asked
her afterwards if I should go get alcohol to wipe the needle cap as per
SOP.

She looked at QA
and said should I sneak and go get it?" She did go and get the alcohol and used it 'on all but
one of the needle caps -that QA watched. After just a few start-ups, the auditor said it was "too
boring" so he was leaving. As soon as the QA auditor left the room, Irene put the top back on
the alcohol jar and put the jar on the bottom of the rolling cart, no longer following SOP as long
as the QA auditor was not in the room.

5/8/97 Thursday HLS

Yao was obbing the P&G monkeys in 97-3630 and 97-3631. They are all being kept in room
954. Currently there are nine primates who pave been operated on. More surgeries are planned
- probably for Friday.

He asked me if I knew which monkeys belonged to which study. There are two study numbers
on the room card at the door of the room, and two obs books but none of the occupied cages
are marked with anything but the animal number written in black paint marker. He went on to
say none of the animal numbers on the cages match up with the list of animals listed on a form
in the book. [Incidentally, there is no clear listing of animals being in the study in the book, he
was going by a list that was part of a sentence on another form like an antibiotic record, or
bodyweight form or something.] He pointed out several monkeys who were not listed in either
book. He went to get Irene, who had us verify their ear-tags against the marked number on the
cage.

When Irene came into the monkey room she was not wearing proper safety equipment, no
tyvex, no hair bonnet, no plastic boots. She had a mask and gloves on and as far as safety
equipment goes, that's it. She was carrying a brown, glass gallon jug and some gauze saying to
me "Don't ever do this." I asked what. She said "Don't ever, ever, bring the acetone into a
monkey room. We're not supposed to - We're supposed to use it in the hall only." The first time I
helped with a primate cage change in large animals I was told the same
thing.

Kevin told Rachel
who was using acetone in a room they weren't supposed to have it in there. Rachel answered
him with a snotty remark and continued to use it in the room telling him we were all right there
and nothing was going to happen. That day she had found the acetone that was in a plastic
bottle with a squeeze nozzle.

The first primate I looked at was marked wrong. On the hi-8 video I pan to the just- removed
number to the left of the black paint-markered 7101F and was in fact
number 7101F.

Page 115

Irene said right away Al had put her in the cage. The rest of the tags matched the number on their cages
but there still was no identifying study number to differentiate between studies. Of my own
accord, I used the paint marker to write the study number on each set of cages.
I asked Yao if he had obbed number 6602F as having a hunched appearance and if he had
obbed 7102F and 7107F as having red exudate in their cages. He said "They're all fine, WNL. I
pointed to the red exudate and said, "There's blood in their cages - don't you think you should
ob it?" He said, "They are all fine. No problem!"

I went to Terry's office and asked her if I had to fill out a vet request for her to look at the surgery
monkey's to see if they needed an analgesic. She handed me memo paper from her desk and
told me to write down the room number and the animal numbers and she'd take a look.
I wrote room 954, 6602 - hunched and 6659 - slightly hunched.

Irene saw Terry go into the monkey room and asked what was going on. I told her I asked Terry
to look at them. I thought at least one of them was in pain and still all hunched over - like
yesterday. Terry couldn't get 6602 to turn around so she could look at her incision. She kept
sliding the false back around hoping to get a glimpse of the incision site. She kept saying, "This
monkey is so thin she looks like she's been in a concentration camp.
She's so thin!"

She looked
at the untouched fruit in their cages and asked if they'd been eating. I said they'd barely eaten
anything yesterday and today. I told her only 7028 even touched the oranges I put in. Terry
looked at the whole tangerines in their cages and said "Tangerines!! Wow!! Yeah - they're not
feeling good if they're not eating those." Finally, she gave up and looked at one of the visible
sites on another monkey. She commented on the really fat monkey in a nearby cage. She
asked Irene "They didn't have any analgesic after surgery, did they?" Irene shook her head. I
looked pointedly at Irene and said, "No, they didn't get anything." [There is a micro-cassette
tape of this - check verbatim.]

Terry asked why they didn't, saying "It's abdominal surgery you
guys, that's really bad..." Irene told her "1 had such a bad day that day and when we were
getting ready to leave I said to the guys' Aren't we supposed to give them an analgesic - I think
it's in the protocol.'" Terry interrupted her saying "It's in the protocol?" Then she said right away
to me "Give them all a shot of analgesic." I asked her if I had to fill out a vet request. She didn't
answer and kept asking Irene why they didn't get one on surgery day. Irene said it was late
when they left and I said sarcastically "Because it was nine o'clock at
night..."

Irene gave she
and me a dirty look and said, "No, it was later, I asked the guys and they said 'no"'. Irene is a
senior technician and performs all kinds duties including TB tests, tattooing, dosing, invasive
surgeries, animals care taking, running studies, doing the paperwork documenting studies,
meeting with study directors to plan studies, drawing blood etc, etc. She has worked at HLS for
almost six years and is more than qualified in HLS' eyes to give a simple IM injection. She
obviously knows how to read a protocol and knows how important it is to
follow them.

I told
Terry the monkey had been hunched over yesterday, as well, and they [Irene, Al, and Brian]
knew it and commented on it but no one did anything. I pointed at two of the primates who have
blood in their cages and said "Those two have blood in their cages. They had blood in their
cages yesterday;' too." Terry didn't respond at all to that.

Terry asked Irene if they didn't get the shot because we didn't have the stuff [medicine]. Irene
told her "We have it, it's just that it had been such a long day..." Irene complained that we've
been too busy and overworked and that they just received the protocol the night before [or
maybe that morning -check tape]. Terry said "I know, I just signed it at five o'clock the night
before so I know you didn't get it...".

Page 116

I interjected that Brian told me he didn't even read the
protocol before the surgeries. Terry asked what we have [for painkiller] and Irene told her "The
Flugemine stuff... We all went into surgery to look at the medicine. There are three bottles of
Flumeglumine in the cabinet. Terry was musing aloud about the dosage saying, "They're all
about 3 kgs right?" Irene said "No, there's the skinny ones and that one
is so much bigger..."

Terry figured aloud and made the dose calcs on the same sheet of paper I'd written the animal
numbers on telling me to give them all .16 of analgesia. Irene was worried that dosage wouldn't
be right for some of them. Terry said, "When it's something like painkiller, it's better to give them
too much." She said "It's such a small amount and a lot of that gets lost in the needle and the
hub of the syringe so it's better to give them a little extra to make up for the lost dose."
(I have always thought the markings on a syringe are accurate and when you draw the medicine
into the syringe from the bottle with the needle on, the needle and hub are then primed once
you get the correct dose into the syringe. After the material is injected, the needle and hub are
still primed and if the plunger on the syringe is pushed all the way in, the correct dosage has
been administered - if it was measured accurately to begin with).

In other words, the material left in the needle and hub doesn't matter if the medicine is
measured with the needle and hub on. If you draw the medicine into the syringe without a
needle, on adding the needle later - then part of the dose would be lost because the needle isn't
primed. I've heard Terry tell y Rodney and Brian and Lisa this before, too. After the P&G pilot
monkey surgery a few weeks ago, she said the same thing "When you're dealing with such a
small amount it's better to give a little more because some of the dose is lost in the hub and the
needle.] Terry mentioned in the room she'd check with the study director to make sure it's ok to give
them analgesic.

Some of the monkeys who weighed close to three kgs got the same dose as the bigger monkey
who probably weighed close to 4.5 -5 kgs. The bigger monkeys probably didn't even benefit
from the painkiller because she figured the calcs based on a 3 kg
monkey.

The post surgical antibiotics are calculated the same way - a mean body weight is determined
through averaging the bodyweights. In study 3631, the mean body weight for the three males
was 4.4 kgs. When they received the first antibiotic injections the dose was based on a mean
body weight of 3.9 kgs, averaged from the weights of the three females and the three males.
The antibiotic dosage differed by 11 mls.

I asked Terry three times if I should write a vet request before she agreed I should.
I had to print up vet requests for 3631, there weren't any in the viability book.
When I went in to have her sign the vet requests Terry asked me if they'd all had their shots. I
told her I have them ready but I wanted her to sign the vet requests before I gave them because
she had mentioned checking with the study director. She said "That's good thinking." and before
she signed the requests she asked me if I thought the hunched appearance and description I
wrote fit all the monkeys in the room. I told her I thought it did, that only one of the females had
eaten and in my opinion I thought the description was accurate but someone else may not
agree.

Page 117

I told her I was specifically concerned about the two I originally told her about and
thought they should all be listed since she authorized analgesia for all of them, mentioning
again that only one of the nine had really eaten anything. She said something about no one
noticing it yesterday and I told her they had noticed it yesterday, that the one female in
particular was hunched but no one did anything about it. She signed the vet requests smirking
at my descriptive comment "... probably because no analgesia had been
given."

She asked me about my leaving HLS, inquiring if I was happy about it or sad or what. I told her I
was happy not to be having to work so much - about having more free time. I told her, now after
this, I should probably be happy because now no one would talk to me in the tech room. She
asked why, and I told her because I filled out vet requests for the
monkeys.

I told Gene that I had asked Terry to look at the P & G primates because they were, hunched
over and not eating. I told Gene they hadn't been given any analgesic after surgery on Tuesday
and he said he knew.

When I saw Brian for the first time after I spoke to Terry, I was alone in the surgical suite. Brian
walked into the room and saw me and started singing "You're a bitch, girl, and you've gone too
far but you know it don't matter anyway."

Terry came into the tech room about an hour after I gave the primate's their shots of painkiller.
She asked Brian and I how they found out about the monkeys upstairs, already. I told her I had
only told her and Gene. Terry said she'd received two phone calls from YP's in the last hour and
she wondered how they'd found out. I told her again I had told Gene. She rolled her eyes and
said that's how they found out then. Gene walked in on the last part of this conversation, but
didn't address the issue.

After he left, Brian and Terry talked about how overworked everyone
was. Brian told her they hadn't even gotten the protocol until just before the surgeries, Terry told
him she knew that because she had just signed it at five o'clock at night the night before. Brian
said he didn't even know they were doing them. Terry complained that there were always so
many mistakes because the company wouldn't pay the money required to employ decent help
and because of that they got all these second-rate employees who
couldn't even speak English.

Yao was sitting next to me when she said that. She also said because they don't pay enough
they keep losing staff to other companies that pay better. She and Brian talked about not having
staff adequately trained for surgery, mentioning wasting all that training [practice surgeries on
live animals] on Jennifer [Fine] and Mahsa who then sat idle at their desks all winter because
there were no studies and where were they now, when they needed them. Terry mentioned
again they hire all these people who haven't got experience and haven't any idea what they're
doing and can't even speak English.

She said you could probably make more working at Burger
King, or McDonalds than working at Huntingdon. She said the company needs to offer higher
wages so they can keep and retain quality people. [This is in contrast to Dean Rodwell's
statement about the average employment length of a technician here should be about three
years and then they should move on. He said this should be considered a training ground and
no one should stick around more than a couple of years before moving on. - Irene, specifically
was very insulted by Dean's remarks but feels that without a college degree her experience is
worthless.]

I saw Nick, Kevin, Walter and Stephanie in the hallway holding a puppy down on a cart. The
puppy's head was turned toward the wall and the technicians were gathered around her hind
end. I had read a draft protocol of an upcoming vaginal study and feared the worst when I
stopped to watch what they were doing.

Page 118

Kevin was using a butterfly needle to obtain blood samples from the puppy?s back leg. He was having trouble obtaining enough blood. Walter and
Stephanie told me its part of the protocol to obtain blood this way. The sponsor claims they
have a technician who can draw blood from the back leg using a butterfly and she can do it
alone without taking the dog from the cage. When Kevin tried twice to get blood and couldn't get
enough of a sample Stephanie and Walter told him to give up and he replied in a stupid voice, "I
will never give up..." and reached for another spaz tube. Stephanie told me it's her study and
they require TK bloods at several intervals and they're using the butterflies so the vein won't
collapse before they're through.

Several times the dog got squirmy and tried to pull away. I had to keep moving in close to help
hold the dog's head and distract him by rubbing his ears. Nick could have easily reached out a
hand to help comfort the dog but he was oblivious to the puppy's discomfort and fear. He stayed
motionless, staring as Kevin jabbed and poked. At one point when the guys were fumbling
around poking at the dog's leg and wondering what they should try next Stephanie grabbed the
dog's head roughly with both hands and said, "I know. They don't know
what they're doing."

The puppy was SO startled he pulled back from her and looked wide-eyed at me. All I could think
about was, I'm relieved they aren't practicing a vaginal dose on this poor vulnerable puppy. The
fact these poor animals are held down and subjected to what ever horror the protocol calls for is
bad enough but to see several inept people gathered around to practice on a completely
helpless victim is unbearable.

I went to talk to Gene about the DSI dog I asked him about. I told Gene the USDA was
encouraging lab adoptions according to their newsletter A WIC. He said he didn't know anything
about it and he was just telling me what Terry told him. He said, "I wonder how I can find out
about that?" I suggested he could call someone ...He told me he'd look into it and let me know.
He said it might be a week or two or three down the road but if he could work something out he
would.

Brian, Lisa, Vao, Irene, and I were spiking IV bags of dose material and weighing them. Al had
been absent from activities most of the day and other employees had made comments about
him having a personal crisis going on. Several people had mentioned not knowing what the
upcoming schedules would look like depending on how things turned out for him. When I saw
Al, he looked like he hadn't slept for a long, long time. An auditor from QA was there. Dian came
in to check on the progress. Al came in to check on the progress and Dian took one look at him
and said to Brain, "Don't let him dose today, ok?" and laughed. Al asked "Why?" and Dian said,
"You just look like you're not really all here." Al brushed it off and muttered something about
being fine.

When we were spiking the bags Brian hassled me about taking the tape off the IV line saying
it's easier to get them into the room with the line coiled up. Lisa said, "It's hard to get the air out
when they're coiled up. Brian weighed the bags with the two pieces of tape on. When he was
through and was signing the paper work Lisa and Irene surreptitiously weighed the pieces of
tape - they weighed .4 grams.

Then Irene started putting collared tape on the weighed bags to
mark the dosage groups and I said loud enough for everyone, especially the QA auditor to hear,
"Oh that's a good idea, that'll help make up for the weight difference when we weigh the bags
post dose, when the other tape is off." Irene, Brian and Lisa looked pointedly at me and then at
the QA auditor sitting nearby.

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Irene saw QA go into the room to watch dosing and said "Oh shit. We never put the right ear-tag
on that one dog and now QA's in there." I said, "She probably won't notice, how could she, I've
never seen them check ear-tags, they just watch to see if we do." She said "I know and I'm
worried that Brian will announce it when he sees it because he'll be mad we didn't do it."
Brian, Lisa, Gene, Yao, Yimmer and I unhooked the dogs in 3627 from the infusion. Gene and
Yimmer removed the jackets and tethers, and cut the catheters and tied them off, Lisa, Vao and
I did ECG's and Brian weighed the dose bags taking blood when there was
time.

After the ECGs he took the remaining bloods while I held. Gene had trouble getting the knotted catheters
to go back under the dog's skin. Twice when I went in to get a dog for an ECG, he pointed out
the knotted catheter stuck on the outside of the partially healed incision site. Though the
catheters were cut-off short to allow them to go back under the dog's skin, most of the dogs
were left with the knotted catheter outside their skin. Once, when I lifted a dog up, he yelped in
pain, I think the catheter tore back through the scabbed incision site once his skin was stretched
out. I hope it was pain from the knot going through and not pain from the catheter ripping loose
inside the dog's leg.

One of the group four dogs was covered in crusty yellow pus. The catheter
exit site was oozing pus and the crust on her side extended form her shoulder blade down to
the abdomen, from the bottom of her neck back to the end of her ribs. I pointed it out to Lisa
who told me "It looks good now, you should have seen it before. We've been watching it and it
looks a lot better now."

I never saw a vet request for any of the dogs having an injected surgery site.
When I was unhooking one dog from the ECG clips by applying pressure to the ends of the clip,
so the mouth of the metal clip would open and release the skin, Brian came over and started
just yanking them off the puppy without applying pressure to open the mouth of the clip. Brian
told me "You don't have to open them up first. Just pull them off. They
like it that way."

Terry came by to talk to Yimmer about his pig study - the hernia surgery pigs. She said pig
number 14M was not doing well at all. She imitated the pigs breathing - something that sounded
like a bad asthma attack. She said she didn't think he'd make it through the night. She pulled
several bottles of medication from her pocket saying "I gave him this, and this and this ...And I
have Melissa in the pharmacy right now looking for a bronchodilator. She told the rest of us -
Brian, Lisa, Yao and I the pig was having severe breathing problems because he'd been
improperly intubated before surgery.

She said "Pigs are very tricky to intubate, with dogs and
monkeys you can keep jamming and jamming it back there until you eventually find the trachea
but with pigs you have to get it on the first try because their tracheas are so sensitive and [she
gave another physical reason why it was imperative to do it right]. She said whomever trached
him had missed and missed causing massive swelling of the tissue in his trachea. Someone
asked her why it happened, why the people tubing didn't know what they were doing. Terry
said, "I know. I tried to schedule a training session about a month ago but it got cancelled and
never rescheduled." When she left, Brian said, "It was Rodney. Rodney trached that pig. He did
it."

The high dose dogs were much quieter than the low dose. They seemed thinner and more
unthrifty. Irene told me she had obbed a couple of them as decreased activity in the morning. I
noticed one of the group twos and two of the group fours were lying motionless in their cages
when I went in.

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The sponsor came in to check on the dogs' condition while we were doing ECG's and
unhooking them. He and Dian came in about 5:00 and spent just a few minutes in the room.
Dog number 4266 was having a hard time breathing when I picked him up to bring him to The
ECG table. He'd been lying motionless in his cage all afternoon, not even getting up when
someone entered the room.

He would wag just the tip of his tail weakly when I stopped to look
at him. When I picked him up I saw his sides were heaving. I brought him to the ECG table and
told Lisa and Yao "This guy doesn't look so good. I think he's on the way out." Neither of them
responded, hooking him up just as they had the others. About halfway through the ECG, Lisa
said, "Boy, he's really having trouble breathing." I mentioned I had told them that a few minutes
ago.

While I held him, waiting for the procedures to begin, he pressed his nose into my neck and
grunted miserably - a noise that sounded like a sigh and a moan. It was so faint, I'm sure no
one else would have noticed it - none of the others let the dogs put their faces up next to their
own.

I held the dog so Brian could take blood. I felt like I was killing the dog when I had to hold his
head up to expose the jugular -like I was cutting off what little air he was getting. Brian said his
blood was very dark and held a tube up for us to see. He said, "Something's going on with this
dog, check this out -it's almost black." I asked if it was coming out slow too, and he told me it
was, it took a long time to get the amount they needed. I put the dog
back in his cage.

A few minutes later, Lisa asked Brian if she should fill out a vet request for that dog. Brian
shrugged and said it didn't matter, telling her it would be fine. She ended up going to Terry's
office to ask her to look at the dog. When they came back, Terry examined the dog and after
listening with the stethoscope said he had "fluid in his lungs" and he "wasn't doing good". She
asked Gene, Lisa, Brain, Yao and I when it had started. Lisa told her half way through the ECG
and I told her it was going on when I got him from his cage.

Gene said that dog and two others
had been obbed as decreased activity as early as this morning. Terry said, "Well, I can treat it. I
can kill it. Or I can do nothing." Before she had finished Gene said, "I don't think the sponsor
would want either of those things [treatment or euthanasia]. Terry went on to say she had
Melissa out at the store picking up a bronchodilator, amophyiline? for that pig and when she got
back with it we could give some to the dog too.

After Terry left, Lisa asked if she should fill out a vet request. Brian said it wasn't necessary.
She pressed it saying, "Well if I do, then at least they know tomorrow he's been looked at
already.

5/10/97 Saturday HLS

Eleanor was the supervisor in charge over the weekend. When I came in I asked her if she
knew if the dog in 3627 had died. She said she didn't know anything about it and asked if there
had been a problem. I just described the situation and she said again she didn't know.
Someone relayed a message to Yimmer to call Terry within an hour - to go check on that pig
and call her if he wasn't any better.

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I saw Eleanor hosing out room 910, study 3323. I went by twice and each time I saw her she
was hosing in front of the cages and all of the dogs were in their cages. I asked her when she
came out "Eleanor, how do you manage with those big dogs - getting them in and out? I said,
"I'm tall and I have trouble lifting them out and back in and you're so
much shorter than I am.

How are you able to do it?" She looked at me and said, "I DON'T take them out, that's how I do
it." I said, "I wondered how you got in and out of that room so fast." Rachel walked by laughing
and said smugly "Yeah, tell her how you get in and out so fast." Eleanor followed her saying "I
did. I told her I don't take 'em out when I clean - big deal."

I asked Lisa about the way things are done at HLS. I told her "It's like no one let me in on the
secret. No one ever really told me what the point is because it seems like every time I say
something about the animals or try to correct mistakes I'm told 'not to worry about it', 'it doesn't
matter'." Lisa sympathized and told me, "[she's] always the one at start up meetings saying
what is this stuff? And what's it going to do - what's it supposed to do?" She said sarcastically
"They love me, too." She told me about the grievance with 3318
again.

I asked her what the
point was I said "This is all for human safety, right? But if we aren't obbing things and doing the
tests accurately, what's the point? Just to make the sponsor's drug look good?" She said, "It's to
please the FDA and regulatory agencies." She said, "That's the important thing." She said, "It
doesn't really matter if the information's accurate or not." I said again, "But it's for human safety
right?" and she said, "Yeah, but a dog's not exactly a human, you know? And just because it
causes a problem in a dog it might not cause the same problem in a human. Something might
happen to a human taking that drug that didn't show up in the
animal."

She said "The data we
get doesn't necessarily translate into something usable for human beings." I told her again, that
I just didn't get it, why we had to do it then. She told me "It's just how it's done. For companies
to get their products approved."

I got some video of pig 14M, the one Terry's been treating. He seemed to be fair active and
wasn't having too much trouble breathing.

One of the primates in the extra colony was loose, the one who had her head stuck in
December. I tried to get her back in her cage but wasn't able to. I noticed she was sticking her
arms in some of the cages and quarrelling with one of the neighbouring primates. She spent a
lot of time hanging around the cage of one monkey as if they got along well and were spending
close time together. In the morning, when I peeked in, she was curled up, asleep, on the top of
her friend's cage.

I went in twice to change ice on urines in a rat study. Rick asked me to do it saying they were
16-hour volumes. Once when I went in I saw one of the rats was out and crawling on a rack
pan. I didn't know what cage he was from and if any of the empty cages had food with test
material so I didn't do anything to try and catch him. Two of the infusion
lines had air in them, one at three and one at six.