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MS Word is not a DTP program--it's a word processor. It's able to do
some DTP tasks in spite of itself--not because it was designed to do so.
QuarkXPress and PageMaker are DTP programs--designed from the git-go to
perform complex DTP tasks primarily, and can do word processing tasks in
spite of themselves. FrameMaker strikes me as a hybrid really, though it
seems like it tilts a little more toward the DTP side.
Also, DTP involves illustration. No one, in my opinion, uses one program
for DTP tasks because no one program typesets, processes, and illustrates
(as well as separate packages do).

So, for what I consider real actual DTP tasks, I choose to use QuarkXPress.
For word processing, I have to use MS Word.
For illustration, I choose Adobe Illustrator and Adobe Photoshop.