INTRODUCTION: Obesity is an important risk factor for cardiovascular diseases. The present study is aimed to evaluate the association of insulin resistance with body mass index (BMI) and body fat percentage (BFP) in obese female.METHODS: Female participants aged 18 years or older, with a BMI ≥ 30 kg/m2, visited the obesity outpatient clinic between January  July 2015, were enrolled into the study. BMI and BFPs of all participants were assessed by bioimpedance analysis. Besides, fasting insulin (FI) and fasting plasma glucose (FPG) levels were measured and HOMA-IR was calculated using the formula; FPG (mmol/L) x fasting insulin (uIU/mL) / 22.5. Participants with a HOMA-IR level of 2.5 and above were considered to have insulin resistance.RESULTS: One hundred and seventy females were included in the study and the mean age was40.53 ± 10.12 years. While there was a positive correlation between HOMA-IR and BMI, no significant relationship was observed with BFP (p=0.01 and p=0.523, respectively). There was a significant relationship between BMI and BFP (p<0.001).DISCUSSION AND CONCLUSION: While there was a relationship between HOMA-IR which is the indicator of insulin resistance, and BMI, no relation was found with BFP.