His question:
I've taken an interest in research and I may want to go the MD/PhD-Virology route. The problem is my science grades aren't that good. I know that I could've gotten better grades but I was unmotivated and not sure about what I wanted to do in life. Would a Physiology SMP help open the MD/PhD doors? Or are those programs only for students who are solely after an MD?

I don't have much to contribute to your question directly but I would recommend that your friend look into exactly what he wants. If he/she wants to improve UG GPA, SMP is not the way to go.
SMP --> Show that you can handle med school curriculum despite your bad grades and your grad school courses to beef up your app. The grades from SMPs show up as graduate coursework on your application.
Post bacc --> Upper level courses to improve UG (s/c)GPA.

This is the type of case where it's going to be extremely difficult to get into medical school at all, let alone MD/PhD. I'd say choose one of medical school OR graduate school and focus on that for now. I've seen people with GPAs like that who are not even able to get a decent graduate school spot.

If he does decide on medical school, he could consider SMP. But with that science GPA, I don't know if a SMP will take him. I'm also a bit pessimistic as to whether he'd ever get in even with a successful SMP. I think if he repeats a lot of courses and gets a near 4.0 in the SMP, he could be successful in the DO route (DO application replaces grades, MD doesn't). As always, you could consider just continuing in undergrad an extra year if allowed. Typically this is much cheaper than an SMP and just as effective.

This is the type of case where it's going to be extremely difficult to get into medical school at all, let alone MD/PhD. I'd say choose one of medical school OR graduate school and focus on that for now. I've seen people with GPAs like that who are not even able to get a decent graduate school spot.

If he does decide on medical school, he could consider SMP. But with that science GPA, I don't know if a SMP will take him. I'm also a bit pessimistic as to whether he'd ever get in even with a successful SMP. I think if he repeats a lot of courses and gets a near 4.0 in the SMP, he could be successful in the DO route (DO application replaces grades, MD doesn't). As always, you could consider just continuing in undergrad an extra year if allowed. Typically this is much cheaper than an SMP and just as effective.

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I know that he is planning a 5th year in undergrad to retake and finish the prereqs and to take a few upper-level bio courses as well. He said a lot of smp programs that he talked to said they would take his gpa as it is on his schools transcript, and his school has a grade forgiveness policy, so he's hoping that will help.

I think he understands how screwed he is but he's still hoping to find a way to slip in somewhere. I will definitely inform him about DO school though. Thanks!