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A few cells could prevent bone marrow transplant infectionsBone marrow transplantation is a life-saving therapy for patients with blood cancers like leukemia or lymphoma. However, the depletion of the patient's immune system prior to transplantation can put patients at risk of for an infection by a virus called cytomegalovirus (CMV) that can be life threatening in these immune-compromised individuals. Now, researchers have found that a very small subset of anti-viral immune cells, transplanted along with a donor's blood stem cells, could be enough to fight and even prevent the disease caused by CMV, in research conducted in mice and published Jan 16th in the Journal of Immunology.http://medicalxpress.com/news/2015-02-cells-bone-marrow-transplant-infections.html
ImmunologyTue, 03 Feb 2015 13:06:08 ESTnews342191160Youngest bone marrow transplant patients at higher risk of cognitive declineToddlers who undergo total body irradiation in preparation for bone marrow transplantation are at higher risk for a decline in IQ and may be candidates for stepped up interventions to preserve intellectual functioning, St. Jude Children's Research Hospital investigators reported. The findings appear in the current issue of the Journal of Clinical Oncology.http://medicalxpress.com/news/2014-12-youngest-bone-marrow-transplant-patients.html
CancerThu, 11 Dec 2014 12:57:47 ESTnews337525060Research may be beating HIV, but a vaccine remains distantThree decades since the onset of the infection in a global population, HIV care and treatment is looking very different. Given the difficulties involved, it is remarkable that having developed good treatments, the global community is racing towards finding a vaccine cure.http://medicalxpress.com/news/2014-07-hiv-vaccine-distant.html
HIV & AIDSFri, 11 Jul 2014 07:48:31 ESTnews324283692New research could expand availability of hand, face transplantsMassachusetts General Hospital (MGH) investigators have made an important step towards greater availability of hand transplants, face transplants and other transplants involving multiple types of tissue. In their report in the American Journal of Transplantation, the team describes how a procedure developed at the MGH to induce immune tolerance to organ transplants also induces tolerance to a model limb transplant in miniature swine. Transplantation of donor bone marrow – either several months before or simultaneous with the transplant – allowed the animals to accept what are called vascularized composite allografts (VCAs) from immunologically mismatched donors.http://medicalxpress.com/news/2014-01-availability-transplants.html
SurgeryThu, 09 Jan 2014 00:20:01 ESTnews308418000Drug offers promising approach to improve outcome for children with high-risk leukemiaCombining the drug gemtuzumab ozogamicin (GO) with conventional chemotherapy may improve the outcome of bone marrow transplantation for some children battling high-risk acute myeloid leukemia (AML), according to a study led by St. Jude Children's Research Hospital. The results appear in the current edition of the journal Cancer.http://medicalxpress.com/news/2013-11-drug-approach-outcome-children-high-risk.html
CancerFri, 15 Nov 2013 12:58:01 ESTnews303742668Immune system marker tied to improved bone marrow transplant outcomesThe risk of death following bone marrow transplantation can be reduced about 60 percent using a new technique to identify bone marrow donors who make the most potent cancer-fighting immune cells, according to research from St. Jude Children's Research Hospital. The findings appear in the September 16 online issue of the Journal of Clinical Oncology.http://medicalxpress.com/news/2013-09-immune-marker-tied-bone-marrow.html
ImmunologyMon, 16 Sep 2013 17:35:14 ESTnews298571702Doctors look at treating specific types of pediatric cancer with viral therapy(Medical Xpress)—Parents do everything they can to protect their children against all of the nasty germs floating around classrooms across the country this time of year. Doctors and researchers at Nationwide Children's Hospital, however, are looking into how those same types of common viruses can actually help treat a child who is diagnosed with certain cancers.http://medicalxpress.com/news/2013-09-doctors-specific-pediatric-cancer-viral.html
CancerTue, 10 Sep 2013 07:04:40 ESTnews298015469Cancer scientists discover novel way gene controls stem cell self-renewalStem cell scientists at the Princess Margaret Cancer Centre have discovered the gene GATA3 has a role in how blood stem cells renew themselves, a finding that advances the quest to expand these cells in the lab for clinical use in bone marrow transplantation, a procedure that saves thousands of lives every year.http://medicalxpress.com/news/2013-08-cancer-scientists-gene-stem-cell.html
ImmunologySun, 25 Aug 2013 13:00:05 ESTnews296635736Radioimmunotherapy could extend lives of advanced lymphoma patientsA new patient protocol for aggressive and recurrent lymphoma that combines intensive chemotherapy and radioimmunotherapy (RIT) may become the most powerful cancer-killing therapy available, with the hope that patients' lymphoma can be eradicated as they prepare for bone marrow transplant, say researchers at the 2013 Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging. In a study presented at the meeting, survival rates without recurrence improved with the addition of RIT, with some having a 100 percent chance of survival over two years.http://medicalxpress.com/news/2013-06-radioimmunotherapy-advanced-lymphoma-patients.html
CancerTue, 11 Jun 2013 09:11:34 ESTnews290160619Discovery may help prevent chemotherapy-induced anemiaCancer chemotherapy can cause peripheral neuropathy—nerve damage often resulting in pain and muscle weakness in the arms and legs. Now, researchers at Albert Einstein College of Medicine of Yeshiva University have discovered that chemo also induces an insidious type of nerve damage inside bone marrow that can cause delays in recovery after bone marrow transplantation. The findings, made in mice and published online today in Nature Medicine, suggest that combining chemotherapy with nerve-protecting agents may prevent long-term bone marrow injury that causes anemia and may improve the success of bone marrow transplants.http://medicalxpress.com/news/2013-05-discovery-chemotherapy-induced-anemia.html
Medical researchSun, 05 May 2013 13:00:01 ESTnews286954775Major advance in understanding risky but effective multiple sclerosis treatmentA new study by Multiple Sclerosis researchers at three leading Canadian centres addresses why bone marrow transplantation (BMT) has positive results in patients with particularly aggressive forms of MS. The transplantation treatment, which is performed as part of a clinical trial and carries potentially serious risks, virtually stops all new relapsing activity as observed upon clinical examination and brain MRI scans. The study reveals how the immune system changes as a result of the transplantation. Specifically, a sub-set of T cells in the immune system known as Th17 cells, have a substantially diminished function following the treatment. The finding to be published in the upcoming issue of Annals of Neurology and currently in the early online version, provides important insight into how and why BMT treatment works as well as how relapses may develop in MS.http://medicalxpress.com/news/2013-03-major-advance-risky-effective-multiple.html
NeuroscienceTue, 26 Mar 2013 11:35:56 ESTnews283516547New method developed to expand blood stem cells for bone marrow transplantMore than 50,000 stem cell transplants are performed each year worldwide. A research team led by Weill Cornell Medical College investigators may have solved a major issue of expanding adult hematopoietic stem cells (HSCs) outside the human body for clinical use in bone marrow transplantation—a critical step towards producing a large supply of blood stem cells needed to restore a healthy blood system.http://medicalxpress.com/news/2013-03-method-blood-stem-cells-bone.html
Medical researchThu, 21 Mar 2013 14:42:26 ESTnews283095727White blood cells found to play key role in controlling red blood cell levelsResearchers at Albert Einstein College of Medicine of Yeshiva University and the Icahn School of Medicine at Mount Sinai have found that macrophages – white blood cells that play a key role in the immune response – also help to both produce and eliminate the body's red blood cells (RBCs). The findings could lead to novel therapies for diseases or conditions in which the red blood cell production is thrown out of balance. The study, conducted in mice, is published today in the online edition of the journal Nature Medicine.http://medicalxpress.com/news/2013-03-white-blood-cells-key-role.html
Medical researchSun, 17 Mar 2013 14:00:02 ESTnews282732266Evidence supports blocking immune response to enhance viral therapy against solid tumorsFollowing several years of study, investigators have found more evidence that viral therapy to treat solid tumors can be enhanced by blocking the body's natural immune response.http://medicalxpress.com/news/2013-03-evidence-blocking-immune-response-viral.html
CancerWed, 13 Mar 2013 12:47:16 ESTnews282397623Cells predict onset of graft-versus-host disease in men receiving BMTs from female donorsStanford University School of Medicine investigators have identified a clutch of cells that—if seen in a male patient's blood after receiving a brand-new immune system in the form of a bone-marrow transplant from a female donor—herald the onset of chronic graft-versus-host disease, or cGVHD. In this devastating syndrome, the patient's tissues come under a vicious and enduring assault by the transplanted cells.http://medicalxpress.com/news/2013-02-cells-onset-graft-versus-host-disease-men.html
Medical researchMon, 04 Feb 2013 15:00:22 ESTnews279195920Epidermal growth factor aids stem cell regeneration after radiation damageEpidermal growth factor has been found to speed the recovery of blood-making stem cells after exposure to radiation, according to Duke Medicine researchers. The finding could open new options for treating cancer patients and victims of dirty bombs or nuclear disasters.http://medicalxpress.com/news/2013-02-epidermal-growth-factor-aids-stem.html
Medical researchSun, 03 Feb 2013 13:00:09 ESTnews279115273Leukemia patients remain in remission more than two years after engineered T cell therapyNine of twelve leukemia patients who received infusions of their own T cells after the cells had been genetically engineered to attack the patients' tumors responded to the therapy, which was pioneered by scientists in the Perelman School of Medicine at the University of Pennsylvania. Penn Medicine researchers will present the latest results of the trial today at the American Society of Hematology's Annual Meeting and Exposition.http://medicalxpress.com/news/2012-12-leukemia-patients-remission-years-cell.html
CancerMon, 10 Dec 2012 00:10:01 ESTnews274319021Boosting immune responses against leukaemia(Medical Xpress)—In the first of its kind, a translational study undertaken at the Malaghan Institute of Medical Research has revealed that boosting the activity of a rare type of immune cell could be an effective way to vaccinate patients with chronic lymphocytic leukaemia (CLL) against their own cancer.http://medicalxpress.com/news/2012-11-boosting-immune-responses-leukaemia.html
CancerWed, 21 Nov 2012 08:48:22 ESTnews272710049Groundbreaking study that may change transplant practicesResearchers from John Theurer Cancer Center at Hackensack University Medical Center, one of the nation's 50 best cancer centers, played an important role in a study published in the New England Journal of Medicine on October 18 that may change the current blood and marrow transplantation practices. The phase 3, multicenter study compared harvesting stem cells from bone marrow rather than blood and suggests there are benefits to both approaches, but no survival differences between the two methods.http://medicalxpress.com/news/2012-11-groundbreaking-transplant.html
Medical researchTue, 20 Nov 2012 09:33:42 ESTnews272626396Father of bone marrow transplant is dead at 92E. Donnall Thomas, a physician who pioneered bone marrow transplants and later won the 1990 Nobel Prize in medicine, has died in Seattle at age 92.http://medicalxpress.com/news/2012-10-father-bone-marrow-transplant-dead.html
OtherSun, 21 Oct 2012 06:20:01 ESTnews270016042Researchers find novel predictor for MDS progression riskResearchers at Moffitt Cancer Center and colleagues have discovered that changes in the physical characteristics of the effector memory regulatory T cell can predict the progression risk of myelodysplastic syndromes (MDS) to acute myeloid leukemia. The finding could improve prognostication for patients with MDS and better inform therapeutic decision making.http://medicalxpress.com/news/2012-09-predictor-mds.html
ImmunologyThu, 13 Sep 2012 04:51:23 ESTnews266730411Race, ethnicity affect likelihood of finding suitable unrelated stem cell donor for cancer patients(Medical Xpress)—Researchers at Moffitt Cancer Center and colleagues have published a study describing the greater difficulty in finding matched, unrelated donors for non-Caucasian patients who are candidates for hematopoietic cell transplantation (HCT).http://medicalxpress.com/news/2012-09-ethnicity-affect-likelihood-suitable-unrelated.html
CancerTue, 11 Sep 2012 03:46:53 ESTnews266553982Improved diagnostic test benefits children with acute myeloid leukemiaEarly treatment response is a powerful predictor of long-term outcome for young patients with acute myeloid leukemia (AML). The information can help physicians decide whether a more intensive approach is needed. Research led by St. Jude Children's Research Hospital investigators has identified the best test for measuring that response and guiding therapy.http://medicalxpress.com/news/2012-09-diagnostic-benefits-children-acute-myeloid.html
CancerMon, 10 Sep 2012 16:50:48 ESTnews266514612Clinical trial seeks to cure advanced Crohn's disease using bone marrow transplantResearchers at Fred Hutchinson Cancer Research Center have opened a clinical trial to test the theory that giving a patient a new immune system can cure severe cases of Crohn's disease, a chronic inflammatory condition of the gastrointestinal tract.http://medicalxpress.com/news/2012-07-clinical-trial-advanced-crohn-disease.html
Diseases, Conditions, SyndromesMon, 23 Jul 2012 12:41:46 ESTnews262266094HIV drug reduces graft-vs.-host disease in bone marrow transplant patientsAn HIV drug that redirects immune cell traffic significantly reduces the incidence of a dangerous complication that often follows bone marrow transplants for blood cancer patients, according to research from the Perelman School of Medicine at the University of Pennsylvania that will be published today in the New England Journal of Medicine. The findings represent a new tactic for the prevention of graft-versus-host disease (GvHD), which afflicts up to 70 percent of transplant patients and is a leading cause of deaths associated with the treatment.http://medicalxpress.com/news/2012-07-hiv-drug-graft-vs-host-disease-bone.html
ImmunologyWed, 11 Jul 2012 17:00:04 ESTnews261241119Antibodies from rabbits improve survival and relapse outcomes of leukemia and myelodysplasiaResearchers at Virginia Commonwealth University (VCU) Massey Cancer Center's Bone Marrow Transplant Program have demonstrated that the use of antibodies derived from rabbits can improve the survival and relapse outcomes of leukemia and myelodysplasia patients receiving a stem cell transplant from an unrelated donor.http://medicalxpress.com/news/2012-07-antibodies-rabbits-survival-relapse-outcomes.html
Medical researchFri, 06 Jul 2012 18:46:28 ESTnews260819182Fertility preservation with cryopreservation of ovarian tissue: from experimental to mainstreamAlthough the first successful preservation of fertility from the freezing, thawing and grafting of ovarian tissue was reported eight years ago,(1) the technique has remained experimental and confined to a few specialist centres. Now, with the announcement of a first pregnancy (and subsequent live birth) in Italy following the transplantation of ovarian tissue, there are indications that fertility preservation is moving into the mainstream of reproductive medicine and into a greater number of centres.(2)http://medicalxpress.com/news/2012-07-fertility-cryopreservation-ovarian-tissue-experimental.html
Obstetrics & gynaecologyWed, 04 Jul 2012 03:35:02 ESTnews260591695Myelodysplastic syndrome treated with deferasirox shows beneficial iron reductionResearchers at Moffitt Cancer Center and colleagues at six other institutions have recently tested a treatment for patients with myelodysplastic syndrome, or MDS, a blood-related malignancy that involves the ineffective production of blood cells, leaving patients anemic and in need of frequent blood transfusions. Because the body has no natural means to reduce iron that accumulates from repeated transfusions, patients' organs can become iron overloaded, leading to heart failure, liver injury, susceptibility to infection, and other complications. Bone marrow failure and conversion to acute leukemia may occur in patients with MDS, necessitating bone marrow transplantation. The disease can be caused by chemotherapy and radiation treatment for cancer.http://medicalxpress.com/news/2012-06-myelodysplastic-syndrome-deferasirox-beneficial-iron.html
CancerFri, 22 Jun 2012 13:45:45 ESTnews259591527Researchers use dual strategy to fight Type 1 diabetes(Medical Xpress) -- University of Florida researchers teamed with colleagues at City of Hope National Medical Center in Duarte, Calif., to devise a new combination therapy that reverses established Type 1 diabetes in mice.http://medicalxpress.com/news/2012-05-dual-strategy-diabetes.html
Medical researchThu, 10 May 2012 06:20:38 ESTnews255849622Chemotherapy proves life-saving for some leukemia patients who fail induction therapyAn international study found that bone marrow transplants are not the best option for some young patients with acute lymphoblastic leukemia (ALL) who fail to attain clinical remission after the initial weeks of intense chemotherapy known as induction therapy.http://medicalxpress.com/news/2012-04-chemotherapy-life-saving-leukemia-patients-induction.html
CancerWed, 11 Apr 2012 17:00:11 ESTnews253377835