Drug-induced liver injury (DILI) is a rare but serious problem with certain widely prescribed drugs and can result in liver failure. It is also a relatively common cause of drug attrition during development. Progress on identifying genetic risk factors for DILI due to a range of drugs using genome-wide association studies will be considered. The genetic associations we have seen, involving both HLA and non-HLA genes, provide new insights into the underlying mechanisms for idiosyncratic DILI and may assist in the development of improved strategies for its prediction and diagnosis.