A novel role of HPV oncoprotein in facilitating NFAT2 dependent cell proliferation.

There is a correlation between NFATC1 genes and the incidence of congenital heart disease in children, and a correlation between different genotypes and allele frequency and the incidence of the disease.

NFAT2 is an important regulator for the anergic phenotype of chronic lymphocytic leukaemia.

Exposure to UVB radiation induces nuclear translocation and stimulates binding between NFAT5 (zeige NFAT5 Proteine) and NF-kappaB (zeige NFKB1 Proteine) proteins in HLE (zeige ELANE Proteine)-B3 cells. These interactions may form part of the biochemical mechanism of cataractogenesis in UVB-irradiated HLECs.

data identified a novel role of SFKs in preventing aberrant NFAT1 (zeige NFAT1 Proteine) activation in resting T cells, and suggest that maintaining this pool of active SFKs in therapeutic T cells may increase the efficacy of T cell therapies

regulation of nuclear localization of NFAT is isoform-specific and dependent on nuclear export processes

NFATC1 Protein Überblick

Protein Überblick

The product of this gene is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. The product of this gene is an inducible nuclear component. It functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A. Five transcript variants encoding distinct isoforms have been identified for this gene. Different isoforms of this protein may regulate inducible expression of different cytokine genes.