John Hopkins University

John Hopkins University Patent applications

Patent application number

Title

Published

20110003710

SELECTIN LIGANDS USEFUL IN THE DIAGNOSIS AND TREATMENT OF CANCER - The present invention provides methods and compositions useful in the diagnosis and treatment of cancer. More specifically, the present invention provides compositions and methods of use comprising a targeting composition comprising a solid substrate, an antibody composition, and optionally a chemotherapeutic agent.

01-06-2011

20100330105

Anticancer Combination Therapies - Methods for treating or preventing hyperproliferating diseases, e.g., cancer, are described. A method may comprise administering to a subject in need thereof a therapeutically effective amount of a chemotherapeutic agent and a DNA vaccine.

12-30-2010

20100010322

METHOD AND SYSTEM FOR DETERMINING A CEREBROVASCULAR AUTOREGULATION STATE OF A PATIENT - A method of diagnosing cerebrovascular autoregulation in a patient includes measuring blood pressure of the patient, measuring, non-invasively, venous oxygen content of the patient's brain substantially simultaneously with the measuring blood pressure, correlating the blood pressure and the venous oxygen content measurements in a time domain, and determining a cerebrovascular autoregulation state of the patient based on the correlating the blood pressure and the venous oxygen content measurements.

01-14-2010

20080269604

Ultrasound Calibration and Real-Time Quality Assurance Based on Closed Form Formulation - Disclosed is a system and method for intra-operatively spatially calibrating an ultrasound probe. The method includes determining the relative changes in ultrasound images of a phantom, or high-contrast feature points within a target volume, for three different ultrasound positions. Spatially calibrating the ultrasound probe includes measuring the change in position and orientation of the probe and computing a calibration matrix based on the measured changes in probe position and orientation and the estimated changes in position and orientation of the phantom.

10-30-2008

20080199061

Quantitative Single Image-Based Magnetization Transfer Weighted Imaging Using an Inter-Subject Normalization Reference Within the Image - Disclosed is a system and method for generating quantitative imagery of demyelination in the spinal cord. The method includes acquiring a magnetization transfer weighted (MTw) MR image of the spinal column, identifying a reference region of interest within the image corresponding to cerebrospinal fluid (CSF), averaging the signal intensity corresponding to the reference region of interest, and computing a ratio, on a voxel-by-voxel basis, of the signal intensity of each voxel by the averaged reference signal intensity. In doing so, normalized MTw images are obtained such that detrimental artifacts such as motion-induced errors, coil loading, and RF coil sensitivity variations are obviated.