For years, I have taken three (one each meal) LEF Magnesium CAPS 500mg per day. Also three magnesium threonates in the AM (144 mg). That is 1644 mg of magnesium plus whatever is in the LEF Mix 9 per day.

In the 2nd week of May, I started consuming some sodium acetate to suppress appetite

I am also on Coumadin due to an artificial heart valve, assigned INR 2-3. None of the above magnesiums have interacted with the Coumadin. My weight loss hit a plateau 2-3 weeks ago, although the sodium acetate still suppressed appetite. On a hunch, I thought I might be getting low on chloride, even though blood work 6 weeks after starting sodium acetate showed my chloride was normal. Sodium acetate metabolizes into sodium bicarbonate (baking soda) in the liver. It is known that people who eat baking soda and other antacids (calcium carbonate) on a regular basis can end up with low serum chloride. None of the supplements I was taking had any significant chloride anions in them. Since sodium acetate greatly reduced my appetite, my ordinary salt (sodium chloride) intake dropped greatly. Based on all of that, I went to a local health food store and picked up a magnesium chloride supplement. LEF does not carry one of those. It was 62mg magnesium (total was 518mg magnesium chloride), so 456mg chloride.

Boom, I felt great, the the weight loss immediately resumed. Three days later, my INR started to rise, and I needed to roughly cut my Coumadin does in half. Nothing on the bottle label about blood thinner warnings. Did some research, and seems that magnesium chloride (and citrate) can increase blood thinning and need a Coumadin dose adjustment. The three 500mg LEF magnesium caps have no effect on my INR, and here a 62 mg magnesium (518 mg mag+chloride) and a big effect. Sleep MUCH better and deeper, and seem more calm too. This is just an on observation.

More research seems to indicate that the chloride anion is needed for metabolism and energy production. My metabolism instantly increased after starting the magnesium chloride.

I found a book (avail for Kindle too) titled "The Magnesium Miracle" by Carolyn Dean, M.D., N.D.

This has a ton of good info on magnesium chloride related to the heart and other body organs. It could put some Cardiologists out of business. Also has a section on Detox (mostly mercury from dental fillings), and using selenium to bind to it. Very good read. Magnesium chloride often fixes AFIB, where a Cardiologist would probably prescribe Amiodarone, a medicine with many side effects. Dr Sircus believes Amiodarone is one of the more toxic forms of iodine, and he says it has no advantages over taking magnesium chloride, sodium bicarbonate, real iodine.

Shortly after adding magnesium chloride to my regimen (also take three LEF 500mg mag CAPS, and three threonates), my INR started rising, needing me to cut my Coumadin dose by about 1/2. In the last week, everything "recovered", my INR started dropping, and is normal now. Also back to my normal Coumadin dose. Seems to be like Tylenol, where at first there is an increase in blood thinning, but after a week, the body adjusts, so the INR and Coumadin dose return to where they were before the Tylenol was started.

Magnesium citrate contains only 12% of "elemental magnesium" (actual magnesium), which is highly bioavailable (40%, I think), and magnesium oxide contains 60% elemental magnesium, which is, according to some studies, only 4% bioavailable, which is described as "extremely low." You can do some math then...but to know for sure, you would need to measure blood magnesium levels after each capsule...

Many people say, magnesium citrate trigger diarrhea more than Mg chloride or Mg chelates.

In some, but not all studies, high calcium intake from supplements (> 2 g/day) was associated with increased risk of heart attack and prostate cancer, but this has not been firmly proven. For now, researchers from Linus Pauling Institute recommend limiting calcium intake for men to to 1-1.2 g per day day.

Hi DDye, how much are you taking of both if you do not mind me asking?

I am having problems in rising my RBC magnesium and despite an increase from 4.09 to 4.26 mg/dL (I am supplementing since about 4 months with 1800 mg of magnesium citrate prescribed by my doctor providing 300 mg of magnesium) I am still under the ref range (4.77-5.84). I also noticed a muscular cramp happening in the night about 2 weeks ago which is very rare but a sign I need to increase maybe absorption or dosage.

Also discussed here . Citrate seems to be a well absorbable form and much in favor by internet wisdom but maybe your mix strategy is better. Glycinate (e.g. here) seems excellent also. Any comment? I will discuss it with my doctor next week.

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