Abstract

The oral toxicity for mice of eight halogenated fatty acids increases in relation to the increase in molecular weight of the substituted halogen and decreases as the carbon chain is lengthened. In the case of four acids the LD50 of which could not be readily determined, substitution of halogen in the beta position markedly reduces the toxicity as does branching of the carbon chain.

Footnotes

Received January 10, 1946.

1946 by The American Society for Pharmacology and Experimental Therapeutics