XP Screen: The Protein Crystal Glue

Figure adapted from [1], used by courtesy of Prof. Annette Rompel, University of Vienna, Austria

The Anderson−Evans polyoxotungstate [TeW6O24]6− (TEW) is a universal and flexible additive for protein crystallization. With its planar structure and a central tellurium atom, it is able to stabilize flexible regions in proteins and provides an anomalous signal for phasing[1].

induce heterogeneous crystallization of two different protein forms in one single crystal (abPPO4, PDB code: 4OUA)[4]

Our new XP Screen contains TEW in 96 of the most prominent crystallization conditions, providing an environment for TEW to improve crystallization and crystal diffraction quality especially for challenging targets.