Seated postural control is an essential component of daily life for non-ambulatory persons with Multiple Sclerosis (PwMS). Multiple sclerosis has negative effects on the central and peripheral control processes, however there is a lack of validated rehabiliatory strategies to improve seated postural control in PwMS. Therefore, purpose of this study is to investigate the effectiveness of an exercise-based intervention as a rehabiliatory treatment for non-ambulatory PwMS. An experimental treatment program was designed utilizing core exercise. The program lasted 3 months, with assessments taking place pre and post exercise intervention. Seventeen participants took part in the investigation. Static and dynamic seated postural control was assessed using force platform metrics. Virtual Time to Contact (VTC) and Seated Instability Index (SII) were calculated. There were no differences in mean VTC or SII between groups. Additional testing revealed significant percent change from zero was found in VTC (p=0.007) as a result of the intervention. This shows that the intervention may be a valid means of improving seated postural control. More research needs to be done to further these findings.