Uxbridge is a town in Worcester County, Massachusetts first settled in 1662, incorporated in 1727, originally part of Suffolk County, and Mendon, and named for the Earl of Uxbridge. The town, (population 13,560, estimate 2012) is located 36 mi (58 km) southwest of Boston and 15 mi (24 km) south-southeast of Worcester, at the midpoint of the Blackstone Valley Heritage Corridor. Two Uxbridge Quakers served as national leaders in the anti-slavery movement. Uxbridge "weaves a tapestry of early America".

The town is 30.4 square miles (79 km2), of which 0.8 square miles (2.1 km2), or 2.73%, is water. It is situated 39.77 miles (64.00 km) southwest of Boston, 16 miles (26 km) southeast of Worcester, and 20 miles (32 km) northwest of Providence. Elevations range from 200 feet (61 m) to 577 feet (176 m) above sea level. It borders Douglas, Mendon, Millville, Northbridge, and Sutton, Massachusetts, plus the Rhode Island towns of Burrillville and North Smithfield.

The 2010 United States Census population was 13,457, representing a growth rate of 20.6%, with 5,056 households, a density rate of 166.31 units per square mile. Population density was 442.66 people/ mile2 (170.77/km≤). Per capita income was $24,540, and 4.7% fell below the poverty line. The number of registered voters was 9,959 for 2010