BlackRock Large Cap Core Fund, a series of BlackRock Large Cap Series Funds, Inc.

(File Nos. 333-89389, 811-09637)

Ladies and Gentlemen:

On behalf of BlackRock Large Cap Core Fund, a series of BlackRock Large Cap Series Funds, Inc., attached for filing are exhibits containing interactive data format risk/return summary information that
mirrors the risk/return summary information in the Prospectuses of BlackRock Large Cap Core Fund (the Fund), dated January 28, 2013, as filed pursuant to Rule 497(e) under the Securities Act of 1933, on February 1, 2013 (the 497
Filing). The purpose of this filing is to submit the 497 Filing in XBRL for the Fund.

Any questions or comments on the 497 Filing should be directed to the undersigned at (212) 839-5583.

Very truly yours,

/s/ Ellen W. Harris

Ellen W. Harris

Enclosures

cc:

Benjamin Archibald, Esq.

BlackRock Advisors, LLC

Sidley Austin (NY) LLP is a Delaware limited liability partnership doing business as Sidley Austin
LLP and practicing in affiliation with other Sidley Austin partnerships.