Acylation Reaction

Researchers in the Aube Group, published in Organic Letters conclusion, have demonstrated an efficient, metal-free variant of the intramolecular FC acylation reaction that simply requires dissolution of a trivially available acyl chloride in HFIP. These results are of both theoretical and practical importance given the stature of the FC acylation reaction in laboratory and industrial scale chemistry.

In comparing the results of the present method with those previously published, these conditions are mild and avoid excesses of harsh acids. The lack of need for an aqueous workup provides a significant practical advantage over classic methods. Although further work to elucidate the mechanism of this reaction is necessary, and underway, the utility of the method for heterocyclic synthesis has been demonstrated and should lead to numerous applications in organic and applied organic chemistry.

Our Mission

To cultivate innovative faculty and student leaders who use molecular tools to address local, national, and global problems.

Safety

The Department of Chemistry is committed to providing a safe and productive environment for both students and staff. The highest standards of scholarship can only be attained in an environment that emphasizes a culture of safety. All laboratories are required to adhere to safety rules and regulations.

Diversity

At the Department of Chemistry, we feel strongly that diversity is crucial to our pursuit of academic excellence, and we are deeply committed to creating a diverse and inclusive community. We support UNC's policy, which "affirms the University's commitment to providing an inclusive and welcoming environment that is free from discrimination on the basis of age, color, creed, disability, gender, gender expression, gender identity, genetic information, national origin, race, religion, sex, sexual orientation or veteran status."