Previous HGNC Symbols for KLF11 Gene

Previous GeneCards Identifiers for KLF11 Gene

Summaries for KLF11 Gene

Entrez Gene Summary for KLF11 Gene

The protein encoded by this gene is a zinc finger transcription factor that binds to SP1-like sequences in epsilon- and gamma-globin gene promoters. This binding inhibits cell growth and causes apoptosis. Defects in this gene are a cause of maturity-onset diabetes of the young type 7 (MODY7). Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Apr 2010]

UniProtKB/Swiss-Prot

Maturity-onset diabetes of the young 7 (MODY7) [MIM:610508]: A form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease. {ECO:0000269 PubMed:15774581}. Note=The disease is caused by mutations affecting the gene represented in this entry.

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Genatlas
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Publications for KLF11 Gene

Role of transcription factor KLF11 and its diabetes-associated gene variants in pancreatic beta cell function.(PMID: 15774581)Neve B … Froguel P(Proceedings of the National Academy of Sciences of the United States of America 2005)34224458