The drug was evaluated in clinical trials involving 1,156 adults with pulmonary arterial hypertension. Trial participants who took the drug did so for an average of about a year and a half. The drug was found to limit worsening of the disease and reduce the need for hospitalization.

Uptravi's most common side effects included headache, diarrhea, jaw pain, nausea, myalgia, vomiting, pain in the arms and legs, and flushing.