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Kamis, 19 April 2012

ICP-MSMS

Inductively
coupled plasma mass spectrometry (ICP-MS) is the technique of choice for
multielemental determinations across a wide range of industries and
applications. Almost all modern ICP-MS systems use a quadrupole mass
spectrometer (QMS), combined with a collision/reaction cell (CRC) to control
interferences.

ICP-QMS
with CRC works well in collision mode - for example in the Agilent 7700 Series
ICP/MS.
The 7700 uses helium (He) cell gas and kinetic energy discrimination (KED) to
filter out polyatomic interferences, providing accurate determination of most
commonly-measured analytes, even in complex and variable matrices.

However,
in reaction mode, ICP-QMS has a major weakness because the reaction processes
in the CRC depend on the ions that enter the cell, and these ions usually vary
from sample to sample. This means that reaction mode has previously been
successful only for simple, known, and consistent sample matrices, such as the
high-purity process chemicals used in the semiconductor industry.

And
even in these simple, consistent matrices, an unexpected contaminant or high
level of another analyte often leads to errors. Until now

The
new Agilent 8800 ICP Triple Quad (ICP-QQQ) has a unique
configuration with an additional quadrupole placed before the reaction
cell. The first quadruple selects the ions that enter and react in the cell,
eliminating the variability and uncertainty associated with single-quad
reaction mode, and delivering unmatched performance and flexibility for
interference removal. The 8800 ICP-QQQ uniquely provides CRC operation with controlled
reaction chemistry. Watching video http://www.youtube.com/watch?v=b9BfKcxmltI

The
first quadrupole (Q1) of the Agilent 8800 ICP-QQQ can be set to operate either
as a simple ion guide or as a bandpass filter, providing the familiarity of
operating modes commonly used on single-quad ICP-MS (no gas mode, collision
mode, reaction mode). Compared with ICP-QMS, the Agilent 8800 provides very
high sensitivity and low random background, so detection limits are
significantly improved.

Predefined
operating conditions and application templates provide simple turnkey operation
for a range of applications. However, for research and problem-solving, the
Agilent 8800 also provides a range of powerful new acquisition modes, based on
the unique ability to select the ions that enter the cell and react:

Precursor
(or parent) ion scan - Q2 is set to target ion mass, while Q1 scans to select
the precursor ions that enter the cell and react

Product
ion scan - Q1 is set to allow only the target precursor ion mass to enter
the cell, while Q2 scans to measure the product ions formed in the cell

MS/MS
mode - Q1 and Q2 are both set to the target analyte mass. Q1 controls the
ions that enter the cell to react, while Q2 rejects all ions except
the analyte mass

Mass-shift
mode - Q1 is set to the analyte mass (for example 75As),
controlling the ions that enter the cell to react. Q2 is set to the
mass of the target reaction product ion (for example 91AsO).

Cluster
ion analysis - Mass shift analysis based on a highly reactive cell gas
such as NH3, which forms cluster ions with the analytes.
Creation and measurement of the target analyte cluster ion is independent
of other analytes, as all potential overlapping ions are rejected using
Q1.

Numerous
performance benefits

The
ability of the Agilent 8800 ICP Triple Quad to control the ions that enter the
collision cell fundamentally changes the way reaction chemistry is performed
with ICP-MS. The Agilent 8800 provides consistent reaction processes in complex
and variable samples, and offers much more selective interference removal than
is possible with ICP-QMS.

These
features dramatically improve performance across a wide range of applications
in material science, semiconductor manufacturing, clinical and life-science,
and any advanced research application where problematic interferences hamper
measurements with single-quadrupole ICP-MS.

The
Agilent 8800 removes the limitations of reaction mode on single-quad ICP-MS,
and uniquely provides:

Selection
of the ions that enter the collision cell, which controls the reaction
processes in the cell to deliver reliable and consistent results in
variable or complex samples.

The
combination of mass-shift mode with rejection of nontarget analytes, which
cannot be done with ICP-QMS because the KED and/or bandpass settings must
be set to transmit the cell-formed product ions from the collision cell to
the quadrupole.

Resolution
of cluster ions that appear at the same mass but are formed from different
analytes. For example in the spectrum , 48TiNH+ is
overlapped by 63Cu when measured by ICP-QMS. Also, 48TiNH(NH3)3
cannot be separated from 63Cu(NH3)3 or 64ZnNH2(NH3)2,
as these cluster ions also appear at mass 114, where they are also
overlapped by 114Cd and 114Sn. With the Agilent 8800
ICP Triple Quad, 63Cu, 64Zn, 114Cd, and 114Sn
are all rejected using Q1, allowing the Ti cluster ions to be determined
free from any overlap.

Built
on a proven and reliable platform

The
Agilent 8800 ICP Triple Quad is unique in its
configuration and performance, yet it shares many hardware components and its
software platform with the market-leading Agilent 7700 Series single-quad
ICP-MS. From the high-performance solid-state radio-frequency (RF) generator to
the dual-mode electron multiplier with nine orders dynamic range, the 8800
utilizes technology that has been field-proven in the 7700 Series.

The
7700 Series remains the benchmark for high-performance, cost-effective ICP-QMS,
delivering unmatched interference removal in He mode. The 7700 is now joined by
the innovative Agilent 8800, offering unsurpassed flexibility and a range of
unique and powerful modes of operation to deliver unparalleled reaction mode
performance for difficult applications.

conclusion

A
Triple quadrupole ICP-MS system has been developed, and the principles of
operation and

advantages
of the proposed system with an additional quadrupole before the cell are explained.

• As an example, Ti detection which is exposed to Cu, Zn
interferences were studied using O2 cellgas and the advantages of the new
system were explained by comparing the experimental results of MS/MS mode and
Single Quad mode.

• Ti detection as a trace impurity in sulfuric acid was
studied using O2 cell gas. By adding He gas to the cell gas, sulfur-based
interferences were dramatically reduced.

• As another example, Rh detection in Pb matrix which is
exposed to doubly charged Pb

interference
was studied using NH3 as the cell gas.

• Single Quad mode which is a compatible operation mode
with the conventional cell-based ICP-MS system is explained. Its advantages
(superior sensitivity for heavy mass elements) over MS/MS mode was studied and
a caution which requires attention (sudden BEC increase) was explained.