Year 480 BC was a year of the pre-Julian Roman calendar. At the time, it was known as the Year of the Consulship of Vibulanus and Cincinnatus (or, less frequently, year 274 Ab urbe condita). The denomination 480 BC for this year has been used since the early medieval period, when the Anno Dominicalendar era became the prevalent method in Europe for naming years.

May – King Xerxes I of Persia marches from Sardis and onto Thrace and Macedonia.

The Greek congress decides to send a force of 10,000 Greeks, including hoplites and cavalry, to the Vale of Tempe, through which they believe the Persian army will pass. The force includes Lacedaemonians led by Euanetos and Athenians under Themistocles. Warned by Alexander I of Macedon that the vale can be bypassed elsewhere and that the army of Xerxes is overwhelming, the Greeks decide not to try to hold there and vacate the vale.

King Alexander I of Macedon is obliged to accompany Xerxes in a campaign through Greece, though he secretly aids the Greek allies. With Xerxes' apparent acquiescence, Alexander seizes the Greek colony of Pydna and advances his frontiers eastward to the Strymon, taking in Crestonia and Bisaltia, along with the rich silver deposits of Mount Dysorus.

The Romans achieve a significant victory against Veii after a close-fought battle. Tensions between the Roman classes flare during the battle. Quintus Fabius and the consul Manlius perish in the fighting.

A sculpture of a Dying warrior is made in the left corner of the east pediment of the Temple of Aphaea in Aegina (approximate date). Today, it is preserved at the Staatliche Antikensammlungen und Glyptothek in Munich, Germany.