Cytokine Gene Polymorphisms in Multifactorial Conditions (Hardcover)

Koen Vandenbroeck

The literature on cytokine genetics is vast, so vast that it is now
practically beyond the time or logistical constraints of most
scientists to successfully keep pace with it. A compilation of the
latest research, Cytokine Gene Polymorphisms in Multifactorial
Conditions brings together, reviews, and structures up-to-date
information on polymorphisms in cytokine genes. It discusses
haplotype structures and linkage disequilibrium patterns in
cytokine gene loci; functional biological effects of polymorphisms;
and genetic associations with disease. The book documents
polymorphisms in the most important cytokine genes, or gene
clusters, and their biological and genetic effects in a multitude
of distinct multifactorial conditions. Unique to this book are the
"disease-centered" chapters examining the role of cytokine gene
polymorphisms in a multitude of multifactorial conditions. The
conditions include autoimmune or chronic inflammatory diseases,
cardiovascular disease, infectious diseases, and longevity. "This
section is a real tour de force" (Grant Gallagher and Michael F.
Seldin, March 2006). Broadening the understanding of the effect of
genetic variations on human immune responses, the organization,
scope, and content of this book make it a valuable and easily
accessible resource. The book integrates genetic, immunological,
and clinical information and will serve as a reference for novice
and expert geneticists, immunologists, cell biologists and
clinicians. It is a must for everyone involved in, or planning,
cytokine genetics or immunogenetics studies.