The Blood Hunters were initially formed from the 386th Clonetrooper Legion, serving with the Maridis Sector group. When Order 66 was initiated, many squads of the 386th were led by the rogue Jedi, Syanne Harkness, to track down and eliminate any potential Force-using threats within the group’s operating area.

After the occupation of the Maridis Sector was established, the newly-appointed High Inquisitor Harkness took direct command of the 386th Legion. From their numbers, Syanne began to train elite squads to use in combating the Jinsai and Antrixian Resistance forces. These elite squads would come to be known as the Blood Hunters, Clonetroopers specialized in combating the Jinsai and Force-users.

The Blood Hunters were an effective unit against the Jinsai, but still suffered heavy casualties when facing Antrixian forces. For replacements, Harkness looked to recruiting from outside sources, human and near-human, in order to keep the Blood Hunter numbers intact. Eventually, the 386th Blood Hunter units would be reduced to 3, 25 man squads.

The Blood Hunters wear Phase II Combat Armor, similar to regular Stormtroopers. The difference comes in the color: Blood red. The Blood Hunters also use an assortment of munitions besides the typical Storm I Blaster Rifle, ranging from light to heavy energy weapons.