Although the original Baldur's Gate does not include any same-gender romance options, player-characters who are men are able to romance Aerie, Jaheira, and Viconia in Baldur's Gate II: Shadows of Amn, and player-characters who are women have Anomen as a same-gender romance option. In the game's 'Enhanced Edition', there are additional options for same-gender relationships, including a bisexual male half-orc blackguard and a lesbian human vampire thief. Unfortunately, both of these options are villainous, so the player-character cannot remain 'good' within the game and have a same-gender romance.

Baldur's Gate II also allows the Tiefling bard Her'Dalis to make use of a male Drow sex slave; the developers have said that he is 'up for anything', which potentially implies that he is considered to be a pansexual character, or else just sexually curious.

The Siege of Dragonspear expansion to Baldur's Gate feature Mizhena, a trans shopkeeper who reveals her gender identity to the player in dialogue.