Struggle for Survival is a defensive card discarded from the hand to reduce damage from the weapons of opposing players in Versus Mode. This makes it very similar to Back to Back, except for its effect. Its text effect states that it reduces the damage of one weapon to 0, if its Gold Cost is 40 or less. This makes it somehwat more effective than the other card while still retaining its additional +1 Action symbol effect. Its second symbol effect grants the player +1 Explore, making it unique. It is the only non-character or weapon card that grants an additional Explore.

The extra Explore comes in handy and can easily be stacked with additional Struggle for Survival cards, making this card a potent combination with the Automatic Shotgun or Triple-Barreled Shotgun, which get multiple Explores. Addittionally, this makes it come in handy for players using Chris Redfield, who gets +5 Damage for every Infected he's fighting.