Aliskiren hemifumarate

Aliskiren hemifumarate is chemically described as (2S,4S,5S,7S)-N-(2-carbamoyl-2-methylpropyl)-5-amino-4hydroxy-2,7-diisopropyl-8-[4-methoxy-3-(3-methoxypropoxy)phenyl]-octanamide
hemifumarate and its structural formula is:

Molecular formula: C30H53N3O6
• 0.5 C4H4O4

Aliskiren hemifumarate is a
white to slightly yellowish powder with a molecular weight of 609.8 (free base-
551.8). It is highly soluble in water, and freely soluble in methanol, ethanol
and isopropanol.

Amlodipine besylate

Amlodipine besylate, USP is
chemically described as 3-Ethyl 5-methyl (±)-2-[(2-aminoethoxy)methyl]-4-(ochlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate,
monobenzenesulfonate, and its structural formula is:

Molecular formula: C20H25CIN2O5•C6H6O3S

Amlodipine besylate is a white
to pale yellow crystalline powder with a molecular weight of 567.1. It is
slightly soluble in water and sparingly soluble in ethanol.

What are the precautions when taking aliskiren and amlodipine tablets (Tekamlo)?

Before taking this product, tell your doctor or pharmacist if you are allergic to aliskiren or amlodipine; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.