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IMAGINE WG aims at exploring the gender-related differences in clinical presentation, diagnosis and treatment of clinical conditions in Internal Medicine.

Despite increasing evidence that an individual’s sex is one the most important modulators of disease risk and response to treatment, consideration of the patient’s sex in clinical decision making (including the choice of diagnostic tests, medications, and other treatments) is often lacking. This is surprising given the increasing interest in precision medicine, which should begin with attention to sex differences in medicine. Sex and Gender Oriented evidence-based medicine could lead to significant improvement of medical knowledge and to a considerable progress of clinical practice.

Despite the aforementioned magnitude, there is still a lack of data on different effect of drugs according to sex. Moreover, there is a reduced awareness of biological, physiological and epidemiological differences between the biology behind the medicine in men and women.