Background Adult individual airway clean muscle (ASM) produce cytokines involved in recruitment and survival of leukocytes within airway walls. Rabbit polyclonal to TranscriptionfactorSp1. antibodies but variably inhibited by fluticasone. TNF-α-induced TNF-R1 and R2 receptor mRNA manifestation was only partially attenuated by fluticasone. Glucocorticoid receptor phosphorylation at serine (Ser) 211 but not at Ser 226 was enhanced by fluticasone. Summary Production of CCL5 CXCL10 and CXCL8 by fetal ASM appears to involve pathways that are both qualitatively and mechanistically unique NSC 105823 to those explained for adult ASM. The findings imply developing ASM offers potential to recruit leukocyte into airways and