Fusion

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Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:query proteins and first shell of interactors

white nodes:second shell of interactors

Node Content

empty nodes:proteins of unknown 3D structure

filled nodes:some 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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Neighborhood

Gene Fusion

Cooccurence

Coexpression

Experiments

Databases

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[Homology]

Score

luxS

S-ribosylhomocysteine lyase ; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (159 aa)

Predicted Functional Partners:

mtnN

5’-methylthioadenosine/S-adenosylhomocysteine nucleosidase 2 ; Catalyzes the irreversible cleavage of the glycosidic bond in both 5’-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5’-methylthioribose and S-ribosylhomocysteine, respectively (231 aa)

a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1

node2

node1 accession

node2 accession

node1 annotation

node2 annotation

score

HMPREF9018_0056

luxS

HMPREF9018_0056

HMPREF9018_0285

ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein

S-ribosylhomocysteine lyase ; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD)

0.724

HMPREF9018_0178

cysK

HMPREF9018_0178

HMPREF9018_1183

Aminotransferase, class I/II

Cysteine synthase

0.826

HMPREF9018_0178

luxS

HMPREF9018_0178

HMPREF9018_0285

Aminotransferase, class I/II

S-ribosylhomocysteine lyase ; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD)

0.797

HMPREF9018_0282

HMPREF9018_0283

HMPREF9018_0282

HMPREF9018_0283

Uncharacterized protein

Uncharacterized protein

0.893

HMPREF9018_0282

luxS

HMPREF9018_0282

HMPREF9018_0285

Uncharacterized protein

S-ribosylhomocysteine lyase ; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD)

0.730

HMPREF9018_0282

mtnN

HMPREF9018_0282

HMPREF9018_0286

Uncharacterized protein

5’-methylthioadenosine/S-adenosylhomocysteine nucleosidase 2 ; Catalyzes the irreversible cleavage of the glycosidic bond in both 5’-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5’-methylthioribose and S-ribosylhomocysteine, respectively

0.694

HMPREF9018_0282

yfiO

HMPREF9018_0282

HMPREF9018_0284

Uncharacterized protein

Outer membrane assembly lipoprotein YfiO

0.842

HMPREF9018_0283

HMPREF9018_0282

HMPREF9018_0283

HMPREF9018_0282

Uncharacterized protein

Uncharacterized protein

0.893

HMPREF9018_0283

luxS

HMPREF9018_0283

HMPREF9018_0285

Uncharacterized protein

S-ribosylhomocysteine lyase ; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD)

0.730

HMPREF9018_0283

mtnN

HMPREF9018_0283

HMPREF9018_0286

Uncharacterized protein

5’-methylthioadenosine/S-adenosylhomocysteine nucleosidase 2 ; Catalyzes the irreversible cleavage of the glycosidic bond in both 5’-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5’-methylthioribose and S-ribosylhomocysteine, respectively

0.694

HMPREF9018_0283

yfiO

HMPREF9018_0283

HMPREF9018_0284

Uncharacterized protein

Outer membrane assembly lipoprotein YfiO

0.953

HMPREF9018_1576

cysK

HMPREF9018_1576

HMPREF9018_1183

Aspartokinase

Cysteine synthase

0.778

HMPREF9018_1576

guaB

HMPREF9018_1576

HMPREF9018_0489

Aspartokinase

Inosine-5’-monophosphate dehydrogenase

0.721

HMPREF9018_1576

luxS

HMPREF9018_1576

HMPREF9018_0285

Aspartokinase

S-ribosylhomocysteine lyase ; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD)

0.738

cysK

HMPREF9018_0178

HMPREF9018_1183

HMPREF9018_0178

Cysteine synthase

Aminotransferase, class I/II

0.826

cysK

HMPREF9018_1576

HMPREF9018_1183

HMPREF9018_1576

Cysteine synthase

Aspartokinase

0.778

cysK

guaB

HMPREF9018_1183

HMPREF9018_0489

Cysteine synthase

Inosine-5’-monophosphate dehydrogenase

0.862

cysK

luxS

HMPREF9018_1183

HMPREF9018_0285

Cysteine synthase

S-ribosylhomocysteine lyase ; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD)

0.893

guaB

HMPREF9018_1576

HMPREF9018_0489

HMPREF9018_1576

Inosine-5’-monophosphate dehydrogenase

Aspartokinase

0.721

guaB

cysK

HMPREF9018_0489

HMPREF9018_1183

Inosine-5’-monophosphate dehydrogenase

Cysteine synthase

0.862

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Network Stats

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Functional enrichments in your networkNote: some enrichments may be expected here (why?)

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Statistical background

For the above enrichment analysis, the following statistical background is assumed: