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ZytoDot ® 2C SPEC TOP1/CEN 20 Probe

The ZytoDot ® 2C SPEC TOP/CEN 20 Probe is designed for the detection of TOP1 gene amplifications. The TOP1 locus appears to undergo frequent copy number alterations which are either focal in nature, e.g., amplicon-driven, or may involve larger chromosomal regions, such as 20q. TOP1 copy number gain has been reported in several tumor entities such as breast cancer, melanoma, gastric cancer, and colorectal cancer.

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