Ubiquitin Conjugation Factor E4 B (UBE4B) ELISA Kits

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Additionally we are shipping UBE4B Antibodies (43) and UBE4B Proteins (3) and many more products for this protein.

We propose a model in which the coordinated action of UBE4B, ESCRT-0, and the deubiquitinating enzymeUSP8 (show USP8 ELISA Kits) enable the endosomal sorting and lysosomal degradation of the EGFR (show EGFR ELISA Kits).

A splice site mutation was found in UBE4b. UBE4B expression was diminished in the high-stage/poor-outcome tumors.UBE4B stands out as the strongest candidate NBL (show NUMBL ELISA Kits) tumor suppressor gene in the region at this stage.

E4B serves as a ubiquitin ligase for FEZ1 (show LZTS1 ELISA Kits) and thereby regulates its function but not its degradation

The regulated expression of these UFD2a isoforms most likely imparts divergent functions that are important for myogenesis.

Characterization of the UFD2a gene.

UFD2a is essential for the development of cardiac muscle, as well as for the protection of spinocerebellar neurons from degeneration induced by endoplasmic reticulum stress.

UBE4B Antigen Profile

Antigen Summary

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes an additional conjugation factor, E4, which is involved in multiubiquitin chain assembly. This gene is also the strongest candidate in the neuroblastoma tumor suppressor genes. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.