When renowned Director, Arnold Albertson (Owen Wilson) casts call girl-turned-actress, Izzy (Imogen Poots), to star in his upcoming play with his wife Delta (Kathryn Hahn) and her ex-lover Seth (Rhys Ifans), his secret life becomes hilariously tangled with his personal life. Izzy turns to her therapist Jane (Jennifer Aniston) for help, but Jane is consumed with her own failing relationship with Arnold’s playwright, Josh (Will Forte), which only increases the confusion in this zany New York love story.