N a m e : March 17, 2010 ETX 103A Exam III Short concise answers recommended 200 points total 1. Arsenic ingestion can be treated with the chelating agents (shown below) BAL, DMPS and DTPS (18 pts). CH 2-CH-CH 2-OH CH 2-CH-CH 2-SO 3 H CH 2-CH-CH 2-C=O | | | | | | | SH SH BAL SH SH DMPS SH SH OH DTPS a. Show a reaction product of arsenite (acid form below) with one of these agents. (They react similarly.) HO-As-OH | OH b. Which of these agents, complexed with arsenite, would be excreted most rapidly in human urine (pH 5)? Explain briefly. c. Which of these agents, complexed with arsenite, would have its excretion increased by taking sodium bicarbonate, increasing the urine pH from 5 to 7. Explain (no calculations needed). 2. A proposal has been made to encapsulate insulin or other pharmaceuticals sensitive to degradation in the upper gastrointestinal tract with a polymer that will release them in the colon. Give a reaction that would plausibly permit this release using a capsule polymer with the repeating units below. (12 pts) 3. Prozac (taken by schizophrenics) inhibits CYP2D6 (debrisoquine hydroxylase). How will the dose-response relation for a schizophrenic patient taking debrisoquine (to reduce his blood pressure) be affected by his taking Prozac? Explain. (12 pts)

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4. Dr. Frank N. Stein creates knockout mouse strains where certain enzyme families are deleted from their genomes. Assume these changes have no effect on untreated mice. a. Indicate in each case below whether the variant mouse would have increased (+) or decreased (-) susceptibility to cancer from benzene exposure, and give a reaction with benzene or a metabolite to illustrate. (16 pts) Susceptibility (+ or -)

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