Located on the corner of Columbus and Grant in San Francisco’s historic North Beach neighborhood, Betty Lou’s Seafood & Grill is a casual family establishment with a friendly vibe and some of the best Seafood & Grill in the City! Serving San Francisco classics including cioppino, sand dabs, steak, and steamers! Sit in the window and experience the heart North Beach, or take a seat at​the bar and visit with the chef. We have something for everyone.