The GOG version of Amerzone lists Windows 10 - for what that's worth. I know they have also said that sometimes Windows 10 has been problematic for some games and for some players. I don't know about Amerzone specifically.

I just edited the original post to show a work-around for running the original disks for Gabriel Knight 3. A member at Mystery Manor couldn't get GK3 from GOG to run on Windows 10, but member RCB posted a work-around.

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In my PC corner for the winter, gaming, knitting and reading.

I don't have 10 installed, but doesn't my installer work for GK3? The GOG version is based on my installer. I would appreciate any input about Win10 compatibility issues.

Collector, yes your installer worked to run GK3 with Win10 using the original CD disc set. For reasons beyond my knowledge GOG states for GK3:

Works on: Windows (XP, Vista, 7)

I don't know if this is just an oversight in not listing Win8 and 10 or that the game tended to be problematic for other reasons with those operating systems. Currently I don't have the GOG version in my possession so unfortunately I can't say for sure at this point.RCB

Good to know. Thanks. I guess that if anyone is having issues it will be a compatibility issue with that particular user's PC.

Probably a number of things on GOG's site that they missed updating as newer versions of Windows have been released. Could be that that info gets updated as releases are updated for bug fixes. They might not want to change that info if they have not tested on the newer Windows.

There is a thread on the Her Interactive website about this that includes Windows 10 users reporting that they have been able to get every single Nancy Drew game (including the first two, Secrets Can Kill and Stay Tuned for Danger) running. The earlier games apparently require the same tweaking instructions that folks used for Windows 7/8. So, although I don't have Windows 10 myself, it would appear that it is possible.