Wellscould, at least, tell a convincing lie; as he did in War of the Worlds

Gorski’d likely #fail as his evil half-brother, “H.G. #Fails”, in World War Peed, and probably didn’t think his readers would get the double-entendre’

Gorski is more famouser for pie in the sky

He’ll never be likened to Samuel Langhorne Clemens, or receive a “Mark Twain Award”

He’s an unlicensed Hackademic Quackademic who believes that bad press is good press, any press is good press

Gorski is the “Guy” who felt he was Scroogled by Google, when he and his public relations (P.R.) team; which reside in the ‎hyperthalamus section of his brain, decided on 12/5/2012 to go pure pseudononsense pseudononscience:

Critiquing: Stanislaw Burzynski: On the arrogance of ignorance about cancer and targeted therapies [1]

wherein he quoted

Dr Burzynski:

“I published the review article in a peer-reviewed journal almost 20 years ago on the principles of personalized gene-targeted therapy”

======================================Gorski:

“Curious as to just what the heck Burzynski was talking about here, I searched PubMed for this alleged review article”

“I couldn’t find it on PubMed”

“His only publications from the 1990s had nothing to do with cancer as a “genetic disease” or “personalized gene-targeted cancer therapy” and everything to do with antineoplastons”

“Perhaps Burzynski proposed this “revolutionary”
new idea in a peer-reviewed article that’s not indexed in PubMed, but if he did I couldn’t find it using Google and Google Scholar”

“I was in graduate school 20 years ago, and was taught back then that cancer was primarily a genetic disease.. ”

“There’s a term called “oncogene,” which describes genes that, when either mutated or too much is made, can result in cancer”======================================

======================================Gorski would have the reader suspend belief, and believe that he’s notsmarter than a fifth-grader; which is entirely plausible

That he could not do a search on the words:

antineoplastons
oncogenes
Burzynski

and find anything whatsoever======================================

======================================
and that he did not have the cranial capacity to access the Burzynski Clinic web-site’s Scientific Publications page:======================================

======================================
The United States Food and Drug Administration(FDA) did NOT have any problem finding it======================================

Burzynskinever explains which genes are targeted by antineoplastons======================================

======================================
A statement which I showed to be incorrect, by pointing out at least 18 different Burzynskiscientific publications which did what Gorski claimed they did NOT [11-12]======================================

======================================
When Dr. David H. Gorski said:
——————————————————————“Personally having pored over Burzynski’s publications”–11/2/2012

“I’ve read many of Burzynski’s papers”–2/18/2013

“I’ve searched Burzynski’s publications”–5/8/2013
——————————————————————
exactly what did he mean by “pored over,” “read,” and “searched”?

Some Bill Clintonesque definition designed to try and stump anyone who’s not smarter than a fifth-grader ?

(“It depends upon what the meaning of the word ‘is,’ is”)

You don’t have to be smarter than a fifth-grader to understand that ifDr. Gorski actually did what he said he did, that he should have been able to conclude without any hint of doubt, thatBurzynskiexplains which genes are targeted by antineoplastons

Where was your head ?

Was your head in Mississippi?

Was your head like a hole ?

Or was your head so far up your “Show Me State” pal Robert J.(don’t call me “Bobby”)Bob (I’m not a doctor, I just pretend like I’m one on the otherburzynskipatientgroup (TOBPG) and houstoncancerquack) blatherskite Blatherskitewicz(known liar) Blaskiewicz’s AstroTurf campaign, that you couldn’t see what you were not doing ?

This is a guywho has been funded by:

a) the Department of Defense(DOD)

b) the NIH (National Institutes of Health)

c) the Conquer Cancer Foundation of ASCO

and

d) the Robert Wood Johnson Foundation

and this is the kind of supposed “Science-Based Medicine”(SBM)“results” he produces ?

This guy is proclaimed as:

“a prolific essayist and managing editor of Science-Based Medicine, a highly-respected blog that exposes non-scientific research and practices”

A “highly-respected blog”?

really ?

Really ??

REALLY ???

You’ve gotta be kiddin’ me !!!

“For the last ten years, he has been a major voice — as himself and pseudonymously — for science-based medicine”

You mean that “Orac”Hack ?

“Dr Gorski also runs an active research laboratory at the Barbara Ann Karmanos Cancer Institute”

Research ?

Is it similar to his “research” which I exposed here?

And yet, after showcasing such “brillianot” research skilz, Tuesday, 7/30/2013, Dr. Gorski was appointed / named program co-director of Michigan Breast Oncology Quality Initiative(MiBOQI); a state-wide initiative to improve the quality of breast cancer care using evidence-based guidelines[13]

He “will be involved in many aspects of the quality initiative”

Let’s hope that one of those aspects is NOT the “research” one

“Dr. Gorski has the breadth and depth of knowledge to effectively lead our very strong Breast Multidisciplinary Team,” said Dr. Bepler

“I have every confidence that Dr. Gorski will continue this very high standard of care.”

Perhaps Dr. Bepler is out-of-touch with reality when it comes to Gorski’s “research” and “standard of care” abilities

I wonder how long it is before his effort at infiltrating evidence-based guidelines with his Science-Based Medicine, raises its ugly hypocritical head ?

During the Holidays, maybe Dr. Gorski will have time to celebrate his promotion with his wife with an evening out, and before he pops the surprise to her about his retirement plans for Castro’s Cuba, he can take her by the hands, stare into her eyes with his big brown eyes; they have to be brown, right (?), because he’s so full of “it,” (?) and tell her these heart-warming words:

Darling, I know, that you know, that what I do brings home the bacon, and so it makes a difference in Michigan

In fact, I wanted to let you know how much of a difference I’m helping to make

1997 thru 2001, African American women breast cancer death rates per 100,000 in Michigan; as reported in the American Cancer Society Cancer Facts & Figures for African Americans, 2005-2006, listed Michigan as the state tied with the 20 most breast cancer cases per 100,000, with 36.2

I’m proud to announce that for the last 2 reporting periods (2011-2014), covering 2003 thru 2009, Michigan is no longer tied with the state with the 20 most cases of breast cancer per 100,000

Michiganis now the state with the 11th most cases of breast cancer in African American women, which rose .5 from 33.8 to 34.3 over the last 2 reporting periods

And that’s not all

African American womenbreast cancer incidences inMichigan, per 100,000, rose from 119.0, 2000 thru 2004 as reported in the 2007-2008 report, up .4 to 119.4, 2006 thru 2010, as reported 2013-2014

Additionally, African American womenbreast cancer death rates inMichigan, per 100,000, rose from 33.8 for 2003 thru 2007, as reported for 2011-2012, up .5 to 34.3 for 2006 thru 2010, reported 2013-2014

And furthermore, breast cancer incidences in Michigan, per 100,000, were 119.4 for African American women for 2006 thru 2010, reported 2013-2014, and 118.7 for 2006 thru 2010 for white women, reported 2013-2014

And also, the breast cancer death rates inMichigan, per 100,000, was 34.3 forAfrican American women 2006 thru 2010, reported 2013-2014, 11.5 more than the 22.8 for white women for 2006 thru 2010, as reported 2013-2014

And I thought you’d be very pleased to know that the estimated new breast cancer cases in women inMichigan, rose from 6,120 in 2008, to 8,140 in 2013

An increase of 2,010

And, Michiganwent from being the state with the 9th most cases of estimated new breast cancer cases, to the 8th

And as if that were not enough great news for you, the estimated breast cancer deaths in women inMichigan, rose from 1,350 in 2004, to an additional 10 more women, 1,360 in 2013

And just like with the estimated new women breast cancer cases, again, Michiganwent from being the state with the 9th most cases of estimated breast cancer deaths, to the 8th

And last, but certainly not least, Michigan cancer death rates dropped from 25.8 in 2008, 1.8 to 24.0 in 2013

However, Michiganwent from being the state tied with the 18th most cancer cases per 100,000, to the state tied with the 11th most

But don’t worry honey

If you’re white like me, because you’re in Michigan, the breast cancer incidence for you per 100,000, went from 133.9 for 1998 thru 2002, as reported 2005-2006, down 15.2 to 118.7 for 2006 thru 2010, as reported 2013-2014

And, even better, white death rates in Michigan per 100,000, dropped from 27.3 for 1996 thru 2000, as reported 2003-2004, 4.5 to 22.8 for 2006 thru 2010, as reported 2013-2014

And best of all, sweetie, if you do get breast cancer and you’re white, you have a 9% better 5-year overall survival rate (69% – whites / 60% – African Americans, and for each stage of diagnosis for most cancer sites)

And I’d be remiss if I didn’t point out that life expectancy is lower forAfrican Americans than whites among women (77.2 vs. 80.9 years) (2013-2014)

If that’s not job security for me, I don’t know what is

The mistake that Gorski made is that he did not take into account that this is not the age of Hitler, Stalin, Lenin, Mussolini, etc

In this day and age, people canNOT get away with adopting lying as a part of a strategy, because the NSA is watching, and so are We, the People

Remain calm

Germans subjugated themselves to Hitler, the Soviets, Stalin, Italians, Mussolini, Cubans to Castro, and none of them were worth subjugating oneself to

None of them were worth being put on a pedestal

None of them were greater than you or I

Gorski is NOT the greater good

Gorski has a degree in “B.S.” from the University of Michigan

I do not have a “B.S.” degree

I’m the one NOT full of“B.S.”

Now that sounds like a story ripe for a journalistic investigation

So, I guess that means Bob Blaskiewicz’s fave “journalist,” Liz Szabo, and USA TODAY, are out of the running for this type of “reporting”

But look on the bright side:

“In his new role, he will work with the Samuel Silver, M.D., Ph.D., who is the MiBOQI program director, as well as assistant dean for Research and professor of Internal Medicine/Hematology-Oncology at the University of Michigan Medical School”

Maybe “the Samuel Silver, M.D., Ph.D.” will be GorskGeeks“checks and balances”======================================“Our only goal is to promote high standards of science in medicine”======================================http://www.sciencebasedmedicine.org/editorial-staff/
======================================

======================================Such risible hyperbole would induce fits of laughter in me if it weren’t such a complete lie======================================
I’m just glad dad got outta Kellogg country while he could
——————————————————————P.S.: Per Dr. David H. Gorski, anything which might erroneously be perceived as a lie about Burzynski, is NOT anything wrong, per Wayne State University[14]======================================

For years, Gorski has been able to comment on Burzynski’s “personalized gene targeted therapy” with impunity

It’s about time he received some personal attention, leading to heapin’ helpings of not-so-Respectful Insolence

All of the below articles by Gorski were tagged as having to do with:

personalized gene targeted cancer therapy, or mention it
——————————————————————http://scienceblogs.com/insolence/tag/personalized-gene-targeted-cancer-therapy/
——————————————————————I AM ADDING TO THIS AS I GO ALONG
======================================[1] – 6/5/2013 – ” … in January the Burzynski Clinic removed all references to antineoplaston therapy on its website … “
——————————————————————[2] – 8/4/2013 – I proved Gorski wrong since Burzynski’s scientific publications regarding antineoplaston therapy are on the Burzynski website
======================================[1] – 6/5/2013 – “Three years should be plenty of time to line up clinical sites for a phase III trial”

“Of course, given that after three years the clinical trial hasn’t been opened, more than likely no reputable institution wants to partner with the Burzynski Research Institute, and ResearchPoint collected its checks”
——————————————————————[3] – 7/18/2013 – This statement by Gorski is disingenuous since 6/3/2013 he reviewed Burzynski: Cancer Is Serious Business, Part II where this issue was addressed, and he made NO COMMENT about it in his review

Gorski can distort, exaggerate, and even lie to the public
======================================[1] – 6/5/2013 – “Another interesting tidbit in the SEC filing is Burzynski’s report of the results of several of his clinical trials”

“They aren’t really “results’ per se, in that the information presented really isn’t provided in a form that really allows other investigators to evaluate it and potentially replicate it”

“Of course, I realize that this is an SEC filing, not a scientific paper in the peer-reviewed literature, but if Burzynski has all this data to produce this table it boggles the mind that, given at least a decade and a half since these trials began, he hasn’t been able to publish any meaningful data thus far”

“That he hasn’t been able to do so is also a big red flag”
——————————————————————[5] – 8/21/2013 – That Gorski has NOT been able to prove that the 4 Burzynski publications I refer to are NOT “meaningful data” is a big red flag
======================================[6] – 6/4/2013 – “It’s a theme that is repeated throughout the report but that ignores the astounding level of sheer deception that goes on at the Burzynski Clinic, the allegations of overfilling, and how Burzynski has abused the clinical trial process to keep treating patients with antineoplastons without actually having to do the science that any other doctor would be required to do to validate a new treatment”
——————————————————————[7] – 6/23/2013 – This is the 1st time I’ve seen Gorski allege “overfilling,” and I sure have NOT seen him provide any proof of that or that Burzynski is NOT doing “the science that any other doctor would be required to do to validate a new treatment”

If anyone is being “deceptive,” it seems to be Gorski
======================================[6] – 6/4/2013 – Dr. Elloise Garside, a research scientists, echoes a lot of the questions I have, such as how Burzynski never explains which genes are targeted by antineoplastons, … “
——————————————————————[8] – 8/7/2013 – Gorski has NO response for where I list where Burzynski “explains which genes are targeted by antineoplastons”
======================================[6] – 6/4/2013 – ” … what the preclinical evidence supporting their efficacy are … “
——————————————————————[9] – 3/16/2013 – Gorski does NOT mention where he’s reviewed “the preclinical evidence supporting their efficacy”
======================================[6] – 6/4/2013 – ” … or what the scientific rationale is to expect that they might have antitumor activity”
——————————————————————[10] – 8/8/2013 – Gorski reviewed “Burzynski: Cancer Is Serious Business” (Part I), but acts as if Dvorit D. Samid was NOT mentioned, and that he is NOT aware that the BurzynskiMovie website contains supporting documentation

I can’t let such statements go unchallenged

It means NadaZeroZip
======================================[6] – 6/4/2013 – “In science, all that matters is what you publish, and Burzynski hasn’t published anything other than case reports, tiny case series, and unconvincing studies, mostly (at least over the last decade or so) in crappy journals not even indexed on PubMed”
——————————————————————[5] – 8/21/2013 – I remain unimpressed that Gorski has NOT written a review of Burzynski’s 2003-2010 phase II clinical trial preliminary reports
======================================[6] – 6/4/2013 – “Without a doubt, the most effective part of the story is the segment in which Dr. Jeanine Graf of the Texas Children’s Hospital is introduced”

“Dr. Graf is the director of the pediatric intensive care unit there and has taken care of lots of Burzynski patients, as her hospital is “just down the road” from the Burzynski Clinic and these unfortunate children are brought to her hospital when they decompensate”

“Indeed, coupled with this segment is an interlude where Luna Petagine’s mother complains that the staff there know and recognize Burzynski patients (and, she notes, hate the Burzynski Clinic)”

“Particularly damning is how Ms. Petagine said that the Texas Children’s Hospital Staff “were always cleaning up Burzynski’s messes.””

“Luna was brought to the Texas Children’s Hospital during her time in Houston, and the staff there recognized right away that she was a Burzynski patient because they had seen so many similar patients suffering the same complications before”

“It was also clear how much contempt the staff there had for the Burzynski Clinic”

“If there’s one thing Panorama did right in this report, it’s showing how seeing so many already dying children show up in our ICU because of hypernatremia due to antineoplaston therapy will do that”

“Perhaps the most devastating part of this segment was seeing Dr. Graf stating, point blank, that she’s never seen a Burzynski patient survive”

“True, she does point out that patients don’t come to her until they are in extremis, but the fact remains that she’s never seen any of them live”
——————————————————————[11] – 4/24/2013 – What is so ridiculous about this is that Richard Bilton wanted numbers from Burzynski, but then when it came to this part of the documentary, he somehow forgets how to ask how many patients this applies to, and Gorski compounds this by trying to blame hypernatremia on antineoplaston therapy, but he refuses to explain how it is that in this Division of Internal Medicine / Department of General Internal Medicine, University of Texas, MD Anderson Cancer Center, Houston, TX, USA, cancer study, over a 3 month period in 2006 re 3,446 patients, most of the HYPERNATREMIA (90 %) was acquired during hospital stay, and these patients were NOT on antineoplaston therapy

Arrogance, dismissiveness, and condescension make him his own worst enemy
======================================[6] – 6/4/2013 – “Burzynski also pulls out the old trope that, if the FDA has been letting him use antineoplastons for 20 years in clinical trials if they weren’t safe and potentially effective, that the FDA wouldn’t let him “sell hope without evidence.””

“(Those of us following Burzynski for a while know, unfortunately, that that isn’t necessarily true.)”
——————————————————————[12] – 4/25/2013 – “The FDA’s Drug Review Process: Ensuring Drugs Are Safe and Effective” advises:

“[T]he emphasis in Phase 2 is on EFFECTIVENESS”

“Phase 3 studies begin if EVIDENCE of EFFECTIVENESS is shown in Phase 2″

The FDA has approved Burzynski’s phase 3 clinical trials, which means that antineoplastons have shown evidence of effectiveness, whether Gorski likes it or NOT
======================================[6] – 6/4/2013 – ” … he goes on to repeat the same refrain he’s been repeating for the last decade or so about how he’s on the verge of publishing all the results that will convince everyone”

“One notes that we’re still waiting”
——————————————————————[13] – 7/25/2013 – Gorski provides NO citation to support his statement, and, he did a review of “Burzynski: Cancer Is Serious Business, Part II,” but conveniently does NOT comment in his review about the refusal e-mail shown in the film, and its suspect content
======================================[6] – 6/4/2013 – “Burzynski needs to publish, but I highly doubt that he will, at least not in a form that is informative to real oncologists”
——————————————————————[5] – 8/21/2013 – I’m waiting for Gorski to prove that the 4 Burzynski publications I refer to are “NOT in a form that is informative to real oncologists”

Why don’t YOU cite a phase 2 clinical trial final publication that has substantially more data fields than the 4 publications I mention ?
======================================[4] – 6/3/2013 – “I refer you to the link for my discussion of many of the problems with the movie”

“Here I will concentrate mainly on issues that I haven’t discussed before, because actually seeing Burzynski II was a revelation”

“(Yes, I put that sentence there on purpose, Eric Merola; quote mine it if you have the cojones)”
——————————————————————[3] – 7/18/2013 – Gorski, don’t wait for Eric Merola to quote you

I’ve quoted you

Now let’s see if YOU have the cajones

MY review of your “review” should be a revelation to YOU
======================================[4] – 6/3/2013 – “I’m referring to Chris Onuekwusi, a man who was diagnosed with stage I colon cancer”

“Instead of undergoing straightforward surgery that we know to have a high probability of success (which, I’ll also point out, can be done these days through minimally invasive laparoscopic techniques), Onuekwusi balked, as described in more detail than in the movie in this article on the Burzynski Patient Group website”

“He had even gone for a second opinion at one of the leading cancer centers in the world, the University of Texas M.D. Anderson Cancer Center, where the surgeon told him the same thing”

“Zolinza is vorinostat, a histone deacetylase inhibitor; Xeloda is capecitabine, which is a prodrug for 5-fluorouracil (5-FU), a pyrimidine analog that inhibits the enzyme thymidylate synthetase and thereby inhibits DNA synthesis to toxic effect in rapidly dividing cells; and Avastin is bevacizumab, a humanized monoclonal antibody directed against vascular endothelial growth factor-A (VEGF-A)”

“As I described in a previous post about Burzynski’s “personalized, gene-targeted cancer therapy,” apparently Burzynski sent Onuekwusi’s tumor to Caris for testing”
======================================[14] – 3/2010 – Burzynski advised that a blood or pathology specimen can be used for testing, and that results from a blood test can be obtained within 2 days, and used and refined by a pathology specimen within 2 to 3 weeks
======================================[4] – 6/3/2013 – “Caris generated a report, as it always does, and Burzynski came up with a witches’ brew of new expensive targeted agents, all said to be “off-label.””
======================================[15] – 5/17/2011 – Well, not exactly

Burzynski made it clear in part 2 of this interview that there is constant searches of medical literature (phase 2 and phase 3 publications) to research the medications to be used based on the cancer genes involved, and that they have worked on software so oncologists can use it to choose the best medications instead of reinventing the wheel and having to review the medical literature again

So, he does NOT come up with a “witches’ brew”
======================================[4] – 6/3/2013 – “One of these drugs is just an old chemotherapy drug in a new form”

“Xeloda is, in essence, 5-FU, a chemotherapeutic drug that has been used to treat colorectal cancer, both as adjuvant chemotherapy and first-line therapy for metastatic disease, for over 40 years”

“There’s nothing really “targeted” about the drug except that it inhibits an enzyme, the way that many drugs do and have been known to do for decades”

“The advantage of Xeloda is that it can be administered orally, which is a good thing”
======================================[16] – What Gorski fails to mention is that Xeloda (Capecitabine) is approved to be used alone or with other drugs to treat:

Stage III colon cancer in patients who have had surgery to remove cancer

May also apply to unapproved uses being studied
——————————————————————[17] – fluoropyrimidine carbamate belonging to class of antineoplastic agents called antimetabolites

FdUMP inhibits DNA synthesis and cell division by reducing normal thymidine production, while FUTP inhibits RNA and protein synthesis by competing with uridine triphosphate for incorporation into RNA strand
======================================[4] – 6/3/2013 – “Similarly, Avastin, although relatively new, is also commonly used for colorectal cancer, albeit usually for metastatic disease and not as adjuvant chemotherapy”
======================================[18] – What Gorski fails to mention is that Avastin (Bevacizumab) is approved to be used alone or with other drugs to treat:

Colorectal cancer that has metastasized (spread to other parts of body)

May also apply to unapproved uses being studied
——————————————————————[19] – A recombinant humanized monoclonal antibody directed against the vascular endothelial growth factor (VEGF), a pro-angiogenic cytokine

Bevacizumab binds to VEGF and inhibits VEGF receptor binding, thereby preventing the growth and maintenance of tumor blood vessels
======================================[4] – 6/3/2013 – “That leaves Zolinza, which is an HDAC inhibitor used to treat cutaneous T cell lymphoma”
======================================[20] – What Gorski fails to mention is that Zolinza (Vorinostat) is a histone deacetylase inhibitor, approved for treatment of cutaneous manifestations of cutaneous T-cell lymphoma (CTCL) in patients with progressive, persistent, or recurrent disease

May also apply to unapproved uses being studied
——————————————————————[21] – A synthetic hydroxamic acid derivative with antineoplastic activity

Allows hydroxamic moiety to chelate zinc ion located in catalytic pockets of HDAC, thereby inhibiting deacetylation and leading to accumulation of both hyperacetylated histones and transcription factors

Hyperacetylation of histone proteins results in upregulation of cyclin-dependant kinase p21, followed by G1 arrest

Vorinostat crosses blood-brain barrier
======================================[4] – 6/3/2013 – “One wonders if Burzynski included a second HDAC inhibitor, his second favorite drug after antineoplastons, sodium phenylbutyrate”
======================================[22] – 11/19/2012 – Gorski, if you had done “exhaustive research” on Burzynski and “Gene-Targeted Cancer Therapy,” you would have viewed this @youtube video:

and you would have heard Mr. Onuekwusi say at 3:45, that he took phenylbutyrate (PB)
======================================[4] – 6/3/2013 – “So, by Merola’s own description, what Burzynski did was to administer a toxic form of treatment that was probably not needed (chemotherapy) using drugs that were not approved for that indication, and apparently didn’t insist that the patient needed surgery”
======================================[23] – 12/13/2012 – Gorski publishes so much garbage that he may have forgotten his article where he posted:

“Then, there is also this video, produced by the Burzynski clinic itself:”

“At around the three minute mark, the announcer states:”

“We combine gene-targeting drugs and low dose chemo, if needed”
======================================[4] – 6/3/2013 – “Now, it’s possible that the combination of drugs did eliminate the tumor”
======================================Gorski, do you think that’s because as mentioned in [15], above, Burzynski would review publications like this ?

[24] – 8/23/2011 – A randomized, phase III trial of capecitabine [Xeloda] plus bevacizumab [Avastin] (Cape-Bev) versus capecitabine plus irinotecan plus bevacizumab (CAPIRI-Bev) in first-line treatment of metastatic colorectal cancer: the AIO KRK 0110 trial/ML22011 trial[1st-line treatment of patients with unresectable metastatic colorectal cancer (mCRC)]
——————————————————————[25] – 11/2/2010 – Vorinostat [Zolinza] synergises with capecitabine [Xeloda] through upregulation of thymidine phosphorylase
——————————————————————[26] – 4/2012 – Phase I–II study of vorinostat [Zolinza] plus paclitaxel and bevacizumab [Avastin] in metastatic breast cancer: evidence for vorinostat-induced tubulin acetylation and Hsp90 inhibition in vivo
——————————————————————[4] – 6/3/2013 – “In my opinion, Burzynski deserves to have his medical license taken away on the basis of how he treated Chris Onuekwusi alone, not even considering all the other dubious things he’s done”
======================================[27] – 8/27/2013 – In my opinion, Gorski deserves to have his medical license taken away on the basis of how he has misinformed, disinformed, and lied about Burzynski, not even considering all the other dubious things he’s done
======================================[4] – 6/3/2013 – “All I can say is that Merola and Burzynski must not have searched very hard, because I quickly found a few … “

“Truly, Merola’s “exhaustive” research skills need some upgrading”

“It took me two minutes to find those articles”
======================================[22] – 11/19/2012 – All I can say is that Gorski must NOT have searched very hard, because I quickly found this @youtube video about Dr. Burzynski – Gene-Targeted Cancer Therapy, which includes a segment on Burzynski’s cancer gene testing at 2:45

Truly, Gorski’s “exhaustive” research skills need some upgrading, since nowhere does it indicate that Burzynski was involved with doing Merola’s research

It took me 2 minutes to find this out

Seeing is believing?

To me seeing is knowing just how intellectually dishonest David Gorski is
======================================[4] – 6/3/2013 – Seeing The Skeptics

“Particularly seemingly damning are a series of Tweets flashed on the screen saying things like the Hope for Laura fund (the fund set up by Laura Hymas to pay for her treatment at the Burzynski Clinic) “appears to be just a money laundry for a lying quack fraud” and “when Laura dies #Burzynski will just move on to his next mark if she doesn’t run out of money first.””

“I think I know whose Tweets these were”

“In fact, I’m sure I know whose Tweets these were, and all I can say to that person is this:”

“Zip it”

“Stop it”

“Put a sock in it”

“In fact, if I’m correct about whose Tweets these are I think I have already done so on Twitter when I’ve seen this person getting too close to attacking cancer patients”

“Still, as utterly insensitive and “dickish” as those Tweets were, they do not represent the majority of skeptics, but rather a few jerks”

“However, we as skeptics need to remember that a few jerks perceived (or painted) as attacking cancer patients can do immeasurable damage to the cause of science-based medicine”

“So if you’re one of those skeptics making comments like that, knock it off”

“If I see you doing it again, next time I will call you out publicly”
======================================[28] – 2/19/2013 – Like this ?
——————————————————————

Of course it's always possible that the money launderers are appearing as themselves in the #Burzynski advertisement.

“@RatbagsDotCom:They will be even more vulnerable when Laura dies and #Burzynski forgets her and moves on to the next mark” #unconscionable https://twitter.com/BurzynskiSaves/status/151115741888909312
——————————————————————[29] – 8/1/2013 – And like you called this guy out ?
——————————————————————
David James (@StortSkeptic) tweeted at 7:08pm – 1 Aug 13:

The new Doctor Who will be Stanislaw #Burzynski. He manages to continually avoid getting cornered and he gets away with murder.

The new Doctor Who will be Stanislaw #Burzynski. He manages to continually avoid getting cornered and he gets away with murder.

======================================[4] – 6/3/2013 – “Then, there was the kicker”

“Eric Merola and Laura Hymas’ fiancé Ben Hymas called me a liar”

“Ben Hymas is quite mistaken in saying about me,”

““He’s lying to them.””

“Moreover, if I had screwed up, I would have admitted it”

“Indeed, part of the reason I looked into this so closely was because I wondered if somehow Merola had actually found a mistake I had made”

“You know the saying about the proverbial blind squirrel occasionally managing to find a nut?”

“It’s possible, albeit unlikely, and in fact there was no mistake”

“There is nothing in deceptive to change my assessment of what happened in the case of or my opinion of Eric Merola”
======================================[3] – 7/18/2013 – As I said before, Gorski’s research skills leave much to be desired

Gorski is a hack and is only funny by accident because he has no filters

If anything, having seen his “review” of Burzynski II, my opinion of Gorski has plummeted even further, something I had thought possible

Gorski, so you got lucky like a blind squirrel and found an error

However, this does NOT change the fact that you’ve been proven to be a liar

Do you want me to subtract one of your lies from the tally ?
======================================[30] – 5/9/2013 – “On what basis is he “targeting” his therapy?”

“As I’ve recounted before, Burzynski usually sends off blood and tissue samples to Caris for testing”

“The Caris Target Now™ test, which since my discussion of Burzynski’s “personalized therapy” appears to have been renamed Caris Molecular Intelligence and is now available at more levels of service (although its reports look much the same to me), is nothing unique to the Burzynski Clinic”

“Anyone who is willing to pay for it can have it, and the report will be the same”

“In any event, there is as yet no convincing evidence that the Caris tests (or any of the other competing tests) result in better outcomes”
======================================[31] – 5/28/2013 – A key pillar of Gorski’s position on Burzynski’s “personalized gene-targeted cancer therapy” is that he alleges that he is “someone relatively knowledgeable about the state of personalized cancer therapy”

I can’t help but wonder why it is that he did NOT know the above information

Maybe he isn’t as knowledgeable about personalized cancer therapy and targeted therapies as he claims

(Oh, wait. He isn’t!)

That’s why when he wrote his “review” on Sheila Herron, he did NOT even refer to Burzynski’s publication:
——————————————————————[32] – 8/2011 – Successful Treatment of Recurrent Triple-Negative Breast Cancer with Combination of Targeted Therapies

When it comes to Gorski’s “story writing” pal Robert J. “Bob” Blaskiewicz, I might allow for some leeway since he’s only a “Perfessor,” but with Gorski on the other hand, I’m not nearly so benevolent

In my ever-Insolent opinion, he and his propagandist are cynically using patients like human shields to deflect criticism

Activities I cannot countenance
======================================[33] – 4/19/2013 – “I now think I probably know with around 95% certainty) and Didymus Judas Thomas (whose identity I’m probably about 75% sure of … also obsessively read anything posted about Eric Merola or Stanislaw Burzynski on any social media”
======================================[34] – 4/19/2013 – Gorski has had over 4 months to say who he thinks I supposedly am, and so far he’s been a failure

But then again, as could be expected, he was wrong about his 2nd theory as well

Finally, I believe that people like Gorski are hypocrites, feeling free to paint Burzynski to their heart’s content (from what I’ve read about Burzynski on blogs, Twitterarticles, and elsewhere, posted by biased, disingenuous, “holier than thou” Skeptics, in them Burzynski is all but portrayed as Satan Incarnate) but running like whipped puppies to the Coward section when either they or Gorski are criticized, no matter how civil, reasonable, or science-based that criticism is (and my blog is all of the above)

The reason is, of course, clear

Having no convincing science, no convincing medicine, and no convincing evidence to support their hero’s antineoplastons hackery or “personalized MUD-targeted therapy for dummies,” they resort to Twitter thuggery

Same as it ever was

One more thing:

If Gorski and his crew of sycophants, toadies, and lackeys are offended by my opinion, my characterization of them that I have based on analyses of claims and observation of the behavior of them and their propagandist, they should try something different to shut me up

I have just the thing, too

Publishing the results of some of the responses to my blog for the scientific community comes to mind first

If Gorski really has the goods, as he and “The Skeptics” claim, then he can best shut me up by bringing the science—solid, convincing science, that is

I’ve said it before many times, and I’ll say it again:

I can be convinced by strong truthful and factual evidence

I have yet to see anything resembling strong evidence from Gorski

At least, if he has such evidence he hasn’t published it yet, preferring to publish a mixture of whiny blog articles where he takes a swipe at Burzynski, tiny-mind series, unimpressive basic science, and the like in bottom-feeding blog articles, some of which aren’t even indexed in PubMed

Nor is a conspiracy of cowardice—excuse me, “The Skeptics”—the reason why trying to ignore criticism will boomerang on “The Skeptics”

It’s all because of their own behavior and willingness to distort, misinform, and slime Burzynski
======================================[35] – 1/14/2013 – “As you might recall, antineoplastons are chemicals that Burzynski found in the urine of cancer patients and that (or so he claims)”
======================================[36] – 2/19/2013 – Seriously, Gorski ?

Where did you come up with that ?

After comparing the blood of healthy people to the blood of people with cancer, Dr. Burzynski found that people with cancer have lower amounts of a certain group of chemicals
======================================[35] – 1/14/2013 – “None of this would have been too bad if only he had actually bothered to do the proper science and clinical trials to demonstrate that antineoplastons (1) have significant anti-cancer activity and (2) have acceptable levels of toxicity”
======================================[10] – 8/8/2013 – Here’s (1)
——————————————————————[37] – 2/19/2013 – And (2)
======================================[35] – 1/14/2013 – “Oh, sure, he has a bunch of clinical trials listed on ClinicalTrials.gov, but virtually all of them are listed as having “unknown” status, and it’s unclear whether most, if any, of them are actually accruing”
======================================[38] – 5/21/2011 – Cancer Breakthrough: 50-60% Success Rate, Cures the Incurable
May 21, 2011
12 phase 2 clinical trials have been successfully completed under supervision of FDA, and now conducting 3 phase 3 clinical trials

Or I can cite from Burzynski’s Securities and Exchange Commission (SEC) filings re his phase 2 clinical trials like you did[1] – 6/5/2013
======================================[35] – 1/14/2013 – “In any case, Merola named the sequel what he named it … along with a website full of a “sourced transcript” to be used by Burzynski minions and shills everywhere to attack any skeptic who dares to speak out”
======================================[39] – Gorski, you should have used the “sourced transcript” so you didn’t end up embarrassing yourself as much as you have

Actually, no one who is an apologist for Dr. Gorski, a.k.a. “Orac,” who over years ago unleashed MUD-targeted therapy on unsuspecting cancer patients, much likes Burzynski

It’s not surprising

Basically, Gorski’s a hack
——————————————————————[40] – Or, you can use this – Burzynski: The Movie — Illustrated Screenplay and Screencap Gallery (Nader Library):
======================================[35] – 1/14/2013 – “Part of the reason that Eric Merola doesn’t like me, aside from the fact that I am willing to help publicize Bob Blaskiewicz’s present to Dr. Burzynski for his 70th birthday on January 23, is that I think that every so often I happen to run into stories about the bad science and unethical nature of Burzynski’s work, and I blog about it”
======================================[41] – 3/26/2013 – Maybe Eric does NOT like you because part of that “present” was your “pal” saying:

“The Burzynski clinic is a place you go to die”
——————————————————————[42] – 8/24/2013 – Gorski, where were you when these 374 children died of brain cancer in #ScienceBasedMedicine clinical trials ?
======================================[35] – 1/14/2013 – “I also run into patient stories”

“Although I don’t cover them as systematically as Bob does, I like to think that what I lack in comprehensiveness of coverage I make up for with my in-depth knowledge of cancer science and treatment”
======================================[43] – 8/31/2013 – Your “in-depth knowledge of cancer science and treatment” ?

You sure have NOT presented a very strong case for that

Is your “man-crush”, Robert J. “Bob” Blaskiewicz still adding false statements to his “stories” ?
======================================[35] – 1/14/2013 – “There are a number of things about this documentary that one can learn if one is involved in caner care and knowledgeable about Stanislaw Burzynski”

“Indeed, he’s even taken credit for pioneering the concept of personalized cancer therapy based on genes and the concept that cancer is a genetic disease, claiming to have published a journal article about it 20 years ago, allegedly long before conventional scientists and oncologists even thought of it”

“The problem, of course, is that, as far as I can tell, he published no such paper and personalized therapy is a concept older than 20 years”
======================================[44] – 7/26/2013 – Indeed, from my perspective Gorski’s an egomaniac, full of the arrogance of ignorance about things like Burzynski’s “personalized cancer therapy”, prone to contemptuously dismissing anyone who has the temerity to question the Great and Powerful “Orac” is god

Because I was able to find the publication with NO problem

“Orac’s” Oracolytes remind me of the “believer” who said:

“god said it, and I believe it, so that settles it”

Of course, “Orac” is Oz tends to clam up when questioned by people who are NOT likely to be sycophants, toadies, and lackeys
======================================[35] – 1/14/2013 – “Given that these are all phase II studies, it’s hard to believe that the FDA would allow Burzynski to keep them open over 13 years, but apparently it has”
======================================[45] – 7/26/2013 – Gorski, why don’t you ask the FDA?

3/29/1996 Then United States Food and Drug Administration Commissioner, David Kessler told the American people:

“The … FDA’s initiatives … will allow …the agency … to rely on smaller trials … fewer patients … if there is evidence … of partial response in clinical trials”
——————————————————————[46] – 6/7/2013 – Then you could be like Blatherskitewicz and do this:

Bob Blaskiewicz (@rjblaskiewicz)
6/3/13, 3:49 PM

@FauxSkeptic @bbc5live I believe he said, “Put up or shut up, you little bitch.” Something like that.

And while your at it, is the “girl from England” referred to in your article, the same one that is referred to in Burzynski 2 ?
======================================[47] – 1/7/2013 – “That’s why I’m joining P.Z. Myers in asking you to help make Stanislaw Burzynski pay cold hard cash to a worthy cause
======================================[41] – 3/26/2013 – Yes Gorski, your “pal” E.Z. P.Z. who wrote:

“The Burzynski clinic is a place you go to die”

He has no shame

But at least ya’ll raised money for a worthy cause while at the same time bringing attention to yourself and what I consider to be your incredibly unethical behavior
======================================[23] – 12/13/2012 – “In fact, from my perspective, it appears to me as though over the last few years Dr. Burzynski has pivoted”

“No longer are antineoplastons the center of attention at his clinic”

“Rather, these days, he appears to be selling something that he calls “personalized gene-targeted cancer therapy.””
======================================[48] – 4/26/2013 – Gorski it’s great to see you’ve been paying attention

” … in 1997, his medical practice was expanded to include traditional cancer treatment options such as

chemotherapy,

gene targeted therapy,

immunotherapy and

hormonal therapy

in response to FDA requirements that cancer patients utilize more traditional cancer treatment options in order to be eligible to participate in the Company’s antineoplaston clinical trials”
======================================[23] – 12/13/2012 – “Finally, around the 4:30 mark, we see Dr. Gregory Burzynski, Dr. Burzynski’s son, talking about genomic profiling of cancers and biomarkers in the blood and in circulating tumor cells. … plus a claim that surgery will no longer be necessary for surgery, what’s left over doesn’t sound too different from what quite a few “conventional” cancer researchers say about “personalized medicine.””
======================================[23] – 12/13/2012 – Gorski, “surgery will no longer be necessary for surgery” ?

Is this “attention to detail”” related to:

“because of the positions I hold at an NCI-designated comprehensive cancer center” ?
======================================[23] – 12/13/2012 – “Clearly, the producer went to great lengths to make Burzynski’s lab look like any other molecular and cell biology lab–even like my lab”
======================================[23] – 12/13/2012 – Gorski, are you trying to suggest that the producer rented or bought equipment to produce this look ?

Do you know how ridiculous that sounds ?
======================================[23] – 12/13/2012 – “When we do this we have a very good chance to have positive results in most patients”

“SS: How many respond?”

“SB: About 85 per cent for whom we have the proper gene signature; about 15 percent do not respond”

“In our responders many of them have tumors which disappear completely and in others the tumors remain small”

“The problem is finding the genetic signature because for many of these different genetic signatures we don’t have blood tests…yet”

“Note that at the time this book was published, Dr. Burzynski was claiming that he could identify who would benefit from specific targeted therapies simply from blood tests”

“If he could do this for real, Burzynski could easily publish in high impact journals like Clinical Cancer Research, the Journal of Clinical Oncology, or another high impact clinical cancer journal”

“Heck, a result like that could probably make it into general medical journals, such as the New England Journal of Medicine or The Lancet, which have an even higher impact factor”

“If he were able to demonstrate that his method of testing tumors and picking targeted therapy could result in a complete response rate anywhere near 85% for breast cancer, even more so”

“If, as he claims later in the chapter, Dr. Burzynski has patients with pancreatic cancer and advanced liver cancer whose tumors have disappeared within two months after he began treatment, the same would be true”

“If, as Burzynski claims, he achieves a 50% complete response rate in advanced brain tumors, again, the same would be true”

“He doesn’t submit his results to these journals”

“Why not?”
======================================[3] – 7/18/2013 – Gorski, why would Burzynski want to publish in The Lancet when you saw the lame excuse they gave in Burzynski 2 for NOT publishing Burzynski’s results; which YOU have refused to address ?

Maybe you could find out if you visited the Burzynski Clinic

Oh, wait

You’ve said that people do NOT need to go to the Clinic to learn things
======================================[23] – 12/13/2012 – “Gene-targeted cancer therapy is currently in its infancy and, except in rare situations outside of the existing currently validated biomarkers (such as HER2, ER, c-kit, and other genes for which targeted therapies exist) for the response of specific cancers, is not to be undertaken outside of the context of a clinical trial“
======================================[23] – 12/13/2012 – Gorski, that’s all well and good for you to write, but you provide NO citation, reference, or link in support of your statement, and you’ve proven that what you post can NOT be trusted

Try again
======================================[23] – 12/13/2012 – “Before discussing how the Burzynski Clinic does personalized cancer therapy, I think it’s worth looking at how real scientists do it right now”
======================================[23] – 12/13/2012 – Gorski, what are you implying ?

That Burzynski is NOT a “real scientist” ?

Because you stated:

“From the description above, it sounded very much to me as though Dr. Burzynski is combining various targeted agents with metronomic chemotherapy“

“I know a thing or two about metronomic chemotherapy, because I was involved in a project whose end result was to be the testing of metronomic chemotherapy against cancer and because the concept is a spinoff of the work of one of my scientific heros, the late Judah Folkman”

“Whether this is what Dr. Burzynski is doing or not with the chemotherapy part of his approach, I don’t know for sure, but it sure sounds like it“
======================================[23] – 12/13/2012 – “Now let’s take a look at how the Burzynski Clinic does it, at least as far as I can figure out from my various sources and from Ms. Trimble”

“In response to my query about personalized gene-targeted therapy offered by the Burzynski Clinic, Ms. Trimble stated that a gene expression analysis is performed, as well as mutational analysis, FISH, immunohistochemistry for selected genes and that a blood test is also performed to measure the “concentration of proteins which are products of most important oncogenes.””

In your 6/3/2013 article you act as if you did NOT know this
======================================[23] – 12/13/2012 – “To support this claim, Ms. Trimble also sent me two papers from the Burzynski Clinic, both of which appeared in a journal I had never heard of before, the Journal of Cancer Therapy, which is clearly not indexed on PubMed because these papers never showed up when I searched PubMed for Burzynski”

“One described Burzynski’s approach for triple negative breast cancer (TNBC)”
======================================[32] – 8/2011 – Gorski, why am I NOT surprised that you’re able to refer to this TNBC publication 12/13/2012, but when reviewing Sheila Herron’s TNBC case 5/28/2013, you completely ignored this publication, even though it specifically states:

“Here we report the successful treatment of metastatic TNBC with combination targeted therapy, and we discuss MDT for a group of 16 women including this patient, whose treatment was based on the same principle” (Pgs. 372-373)

How do you NOT provide a link to a previous article you wrote on the same subject, like you normally do ?
======================================[23] – 12/13/2012 – “It turns out that perhaps the best description of what “personalized” treatment means in Dr. Burzynski’s hands comes from the Texas Medical Board’s complaint against him, which can be found in over at the Ministry of Truth or at Casewatch”

“This complaint is based on the cases of two patients”

“First, here’s Patient A, who is described in the complaint thusly:”

“1. Patient A:”

“a. In approximately May of 2008, Patient A presented to Respondent with breast cancer that had metastasized to her brain, lung, and liver”

“b. Respondent prescribed a combination of five immunotherapy agents – phenylbutyrate, erlotinib, dasatinib, vorinostat, and sorafenib-which are not approved by the Food and Drug Administration (“FDA”) for the treatment of breast cancer, and which do not meet the FDA’s regulations for the use of off-label drugs in breast cancer therapy”

“c. In combination with the five immunotherapy agents, Patient A was prescribed capecitabine, a chemotherapy agent”

“This is what’s known as “throwing everything but the kitchen sink” at the tumor without any thought of interactions, as most of these agents have no proven role in the treatment of breast cancer”

“It works by inhibiting the tyrosine kinase of the epidermal growth factor receptor (EGFR) and is not FDA-approved for breast cancer”

“However, it’s not unreasonable to think that it could work in breast cancer, as EGFR is believed to be important in some breast cancers, which is why this is an area of active research”

“Dasatinib (trade name: Sprycel) is also a kinase inhibitor”

“It inhibits the Src family tyrosine kinase”

“Vorinostat is a histone deacetylase inhibitor approved for use against cutaneous T-cell lymphoma”

“Finally, Sorafenib is another tyrosine kinase inhibitor that inhibits the tyrosine kinases of different receptors, as well as raf kinases”

“The big problem with this sort of approach is that the more drugs you add, no matter how “targeted” they are, the more chance for interactions that increase toxicity, and throwing all these kinase inhibitors together in a cocktail with chemotherapy is a recipe for disaster, particularly because such cocktails haven’t been tested in proper phase I clinical trials to evaluate toxicity”
======================================Gorski, you make it sound like you reviewed the medical literature and found NO phase I clinical trials were conducted, or NO combinations of some of these drugs were tested

“Lots of chemotherapy”
======================================[23] – 12/13/2012 – Gorski, what was the date of the video you quoted above, about low-dose chemotherapy ?
======================================[23] – 12/13/2012 – “Instead, skirting the line between science and pseudoscience, Dr. Burzynski gives every appearance of recklessly throwing together untested combinations of targeted agents willy-nilly to see if any of them stick but without having a systematic plan to determine when or if he has successfully matched therapy to genetic abnormality”
======================================[15] – 5/17/2011 – That sure explains away the review of the medical literature (phase 2 and 3 clinical trials)

NOT
======================================[55] – 12/12/2012 – “Note: Orac is away In the meantime, he is rerunning some of his favorite posts”

“Given that the blog seems to have been infiltrated with Burzynski trolls again now seems a perfect time to rerun a post of Orac’s from about a year ago”
======================================[55] – 12/12/2012 – “Orac”, who’s theidiot who posted that “trolls” had taken over the blog, and who were these “alleged”“trolls” ?

Inquiring minds want to know
======================================[55] – 12/12/2012 – “No one would ever confuse my reviews with those of Roger Ebert (mine tend to be a lot longer, for one thing, and concentrate on science much more than moviemaking), but I do sometimes subject myself to these movies when I can find a way to watch them online that doesn’t cost me any money”
======================================[55] – 12/12/2012 – Gorski

“Concentrate on science” ?

really ?

Really ??

REALLY ???

Did you actually count how many characters and / or words you devoted to criticism instead of “science” ?
======================================[55] – 12/12/2012 – “In the process, I might even look into a couple of Burzynski’s studies that I’ve read and found to be–well–lacking, to put it kindly”
======================================[2] – 8/4/2013 – Gorski, why don’t you “look into” Burzynski’s 2003-2010 preliminary phase 2 clinical trial reports, and write a “review” ?
======================================[55] – 12/12/2012 – “One part of the movie that truly insults the intelligence of anyone with a modicum of knowledge about drug therapy occurs near the beginning of the movie”

“It’s a part that, as a cancer surgeon who is interested in targeted therapies for breast cancer, I found particularly idiotic”

“First, there is a screen with this caption:”

“Antineoplastons target the specific genes that allow cancer to grow and flourish”

“A little later we see:”

“There are currently over 25 FDA-approved gene-targeted cancer drugs on the market today”

“Many of them can only target single genes”

“All of which is true but irrelevant if Burzynski is trying to sell antineoplastons as targeted therapy”

“Now here’s the kicker:”

“Antineoplastons work on close to one hundred different genes”

“You know what you call a drug that works on “close to 100 genes”?”

“I don’t know either, but you don’t call it a “targeted” therapy unless all those genes are genes affected by the single target being inhibited; i.e., are downstream targets of the gene targeted by antineoplastons”
======================================[5] – 8/21/2013 – Gorski, how do you NOT know “the single target being inhibited … are downstream targets of the gene targeted by antineoplastons”, when you did NOT even know which of Burzynski’s publications discussed which genes are “targeted by antineoplastons” ?
======================================[56] – 12/5/2012 – “In reality, oncologists shun Burzynski—and rightly so, given that he has yet to publish anything resembling a convincing result suggesting the efficacy of his antineoplastons against cancer”

“The reason oncologists don’t respect Burzynski is because of how he hasn’t show that his treatments work better than conventional treatments—or even that they work at all—and because of the way he abuses patients by charging them huge sums of money to participate in a clinical trial”

“Those are the reasons legitimate oncologists, at least those familiar with Burzynski, look askance at him”

“How could they do otherwise?”

“The ones who don’t take him seriously are the ones who know him best”
======================================[57] – 4/24/2013 – Gorski, that certainly explains why this 2011 cancer study that references Burzynski:

Phase II trial of tipifarnib and radiation in children with newly diagnosed diffuse intrinsic pontine gliomas