Posts Tagged ‘TBI’

Israeli researchers working with an international team have discovered that a common blood pressure medication can prevent epilepsy from developing after a traumatic brain injury.

The discovery is described in an article published in the current issue of the Annals of Neurology.

Physiology and Neurobiology Professor Alon Friedman works at the Zlotowski Center for Neuroscience at Ben Gurion University of the Negev in southern Israel. He worked with Daniela Kaufer, UC Berkeley Associate Professor of Integrative Biology at the Helen Wills Neuroscience Institute and Uwe Heinemann of Charite-University Medicine in Germany on the 10-year study.

In 60 percent of the experimental rats tested, the medication – losartan (Cozaar) – prevented the development of seizures following injury in which 100 percent of controls developed seizures. Of the 40 percent that did develop seizures, the researchers said the rats averaged only one quarter of the number of seizures typical for untreated subjects.

Medication administered for three weeks following injury was sufficient to prevent most cases of epilepsy in normal subjects in the subsequent months, the researchers said.

“This is the first-ever approach in which epilepsy development is stopped,” Friedman explained, “as opposed to common drugs that try to prevent seizures once epilepsy develops… so we are excited about the new approach.”

The researcher added that the study provided a new way to potentially prevent epilepsy in patients after brain injuries occurred, and once they had already developed an abnormal blood-brain barrier. The best news, he said, is that the drug stops the epilepsy from starting, rather than simply suppresses the symptoms.

OK, the headline itself is a dead giveaway. The two worst perpetrators of brain injuries in the world are teaming up to fight them? Seriously? Why don’t you, instead, like – stop causing them?

Read on:

The top leaders of both organizations — Army Chief of Staff Gen. Ray Odierno and NFL Commissioner Roger Goodell – met at the U.S. Military Academy Aug. 30 to discuss the issue and sign a letter of agreement to continue sharing resources to combat TBI.

“Mental and physical toughness, discipline, team over self and stressing the importance of resilience are fundamental to the cultures of both the NFL and the Army,” Odierno said. “We have the Warrior Ethos, reinforced by the Soldier’s Creed.”

OK, I can accept a certain amount of TBI on the battlefield. You run into some mean people out there, you’re going to get hurt, some of it will go to your head. But on the Football field? Why? What’s the point of sending young men in the prime of their lives to hurt each other so brutally? What’s the point?

The point is it makes money. Americans, like the Romans of a couple millennia ago, enjoy this stuff. I don’t begrudge them their joy. I don’t begrudge these young men of average to high intelligence their decision to trade in their brains for some cash. Those are choices mature adults should be permitted to make.

But don’t treat us, the readers, as if we too have sustained TBI with drivel like this from NFL commissioner Goodell:

“Together, we can make a big difference, sharing medical research, and helping players and fighters and bringing a greater awareness to society as well. I believe we can change our cultures, with athletes and soldiers sharing their experiences.”

Change our culture? You are the blessed commissioner – make it a game losing violation to bang into an opposing player in ways you wouldn’t dare treat someone’s car, much less someone’s God given body.

A 2000 study surveyed 1,090 former N.F.L. players and found more than 60 percent had suffered at least one concussion in their careers and 26 percent had had three or more. Those who had had concussions reported more problems with memory, concentration, speech impediments, headaches and other neurological problems than those who had not, the survey found.

A 2007 study conducted by the University of North Carolina’s Center for the Study of Retired Athletes found that of the 595 retired N.F.L. players who recalled sustaining three or more concussions on the football field, 20.2 percent said they had been found to have depression. That is three times the rate of players who have not sustained concussions.

And if that’s not enough, read up about potential links between repetitive head trauma in football and a serious health condition, called chronic traumatic encephalopathy (CTE). Originally associated with boxers, CTE is a type of neurological deterioration caused by repetitive head trauma. (Brawn and Brains: Looking at NFL Head Injuries).

I like Football, I’m a guy, I enjoy watching territorial wars, my brain is hardwired to go gaga over it. (The fact that I’m a Jet fan only means that I’m really bad at picking sides.) Still, I derive zero joy from seeing players getting hurt. I’m all for adopting the Touch Football rules. You got tagged with the ball – play stops.

It should open the field for less hefty and more agile and athletic defenders.

And would bring and end to TBI. Immediately.

This was my morning rant about things I can’t possibly change. I feel much better now and ready to move on with my day.

What does an elected official in his fifties have in common with a young Chassidic father, a young mother who works as a freelance copy editor, and a 21-month old infant? All four individuals, from very different backgrounds and walks of life, suffered a stroke which robbed them of some of their previous abilities, and prompted an individualized recovery process which is likely to last for the rest of their lives.

Of the four, only New York State Assemblyman Steven Cymbrowitz, representing the 45th Assembly District in Brooklyn, experienced the classic symptoms that we usually associate with a stroke, a sudden interruption of normal blood flow to a portion of his brain as the result of a blood clot, which nearly took his life one morning in March, 2005. They are all part of a fellowship of more than 500,000 people in the United States each year who suffer a stroke or traumatic brain injury (TBI), leaving one-third of them with a permanent disability.

Strokes are the third leading cause of death in the U.S. They are usually associated with middle aged or elderly individuals, but they can befall individuals at any age, even young children. According to Chavie Glustein, the founder and director of BINA, a Brooklyn-based organization providing a broad range of services to hundreds of families dealing with the aftermath of stroke and brain injury, in discussions of treatment and recovery, TBI is often included with stroke, because its impact on the patient is often virtually identical to that of a stroke. TBI can result from common events such as falls, vehicular accidents, and sports injuries, to name a few, and is a leading cause of death and disability in children and young adults.

While the severity and effects of stroke and TBI vary widely, medical science has developed an effectively arsenal of medical equipment, medications and therapies to treat victims of both conditions, and to assist in their recovery. Those who survive often require years of therapy and rehabilitation, and even those who successfully recover will still have to deal with the effects years after resuming their normal day-to-day activities.

Lifesaving Decisions

Assemblyman Cymbrowitz credits his wife Vilma for saving his life by telling the ambulance driver who responded to her 911 call to take him directly to the Stroke Center of Maimonides Hospital in Brooklyn. There a team of specialists used the MERCI (Mechanical Embolus Retrieval in Cerebral Ischemia) Retriever to remove the blood clot which was blocking one of his cerebral arteries.

Cymbrowitz survived because he received aggressive treatment within the critical initial 180 minute period from the onset of symptoms, what doctors call the “golden hour.” The prompt treatment also limited the damage the stroke did to his brain, and enabled him to recover very quickly. He returned to Albany to resume his official duties just two weeks after suffering the stroke, but today, seven years later, he is still dealing with its more lasting effects.

Younger Victims

A. is a 5-year-old girl who suffered extensive brain damage from a stroke at the age of just 21-months. Her doctors still do not understand what triggered the stroke, but the effects of her cerebral infarction (the death of brain tissue due to the interruption of the blood supply), were devastating.

A. had experienced some earlier developmental delays, but just before she suffered her stroke, seemed to be catching up. She was babbling happily and on the verge of starting to walk, when the stroke came on without warning. In a coma and barely breathing, A. was rushed to the hospital by her frantic parents.

When she came out of the coma, it was soon clear that she had suffered a major setback to both her physical and cognitive development. She could no longer stand or even crawl. She was subject to seizures, and lost her ability to babble.

Medication stopped the seizures and thanks to intensive physical and occupational therapy, A. can now walk and even run. But she is still at a cognitive development level of about 12-18 months. She has virtually no ability to communicate, and her progress in speech therapy is painfully slow.

A. now attends a special needs school not far from her home in Great Neck, Long Island. Her parents are grateful for the support they have received from their community and groups like BINA, which provided them with encouragement and the latest information on the wide range of treatments and resources available for their daughter and other stroke and TBI victims.

Causes and Effects

The survival rate for stroke and TBI has been significantly improved by the establishment of stroke centers like the one at Maimonides, equipped with the latest imaging equipment, medications and treatment devices, and a specialized staff experienced in their effective use. A significant advance is the introduction of computer-controlled robotic devices such as the Lokomat (depicted on the cover) at leading rehabilitation and stroke recovery centers around the world. Lokomat provides patients who cannot stand or walk on their own with physical support against the pull of gravity and motorized assistance for their limbs and muscles. It also has a computer monitor which uses video game-type simulations to give the patient instant positive or negative feedback on their movements on the treadmill. The result is more productive therapy sessions, speeding up the recovery process.