Since the website offers true 1080p for videos, and with other apps like XBMC not working as well, I was wondering if there were any keyboard shortcuts for playback of videos that I could map to my universal remote. I tend to watch PC videos off my TV while it's directly connected to my PC through HDMI.

In addition, I was wondering if there were any scripts (such as Auto Hotkey) for switching the display and audio from my PC to my TV (meaning, it turns off one display so it plays on the other, and switches to the desired audio output).

UP ARROW: Volume +
DOWN ARROW: Volume -
LEFT ARROW: 10sec Rewind
RIGHT ARROW: 10sec Fast Forward
SPACEBAR: Pause/Play
TAB: Multi-function; Depending on how many times you press it, while used with ENTER, it can Pause, Play, Skip Episode, Toggle Autoplay, Create a Pop-Up Player, Enable Fullscreen, Mute, and Unmute.
ESCAPE: Disable Fullscreen.
F: Enable Fullscreen
M: Mute/Unmute
LEFT BRACKET: Rewind to start of episode.
RIGHT BRACKET: Fast-Forward to the final portions of episode.

Now if only there was a way to set up a script so that it turns off my PC display and switches audio ports when I play a video, or better yet a key that I can map that to with the remote.

There're most likely no hotkeys for changing A/V outputs through Crunchyroll, but there might be something you can set up for it on your computer.

On my laptop, I can change my A/V outputs by pressing FN + F8. If you have something like that on your computer, maybe you could set it up where the FN key is locked, so that (for example) F8 alone would change the output. Then you might be able to set it up on your remote. Of course, if you're using a desktop PC rather than a laptop, I don't know if it'll have an FN button...I know that most desktop PCs don't...