Whisenhunt was considered for several head coaching openings, including San Diego's, but the Chargers opted to hire Denver Broncos offensive coordinator Mike McCoy for the post.

Whisenhunt spent six season as head coach in Arizona, leading the team to their only Super Bowl appearance following the 2008 season. With a record of 45-51, he is the winningest coach in Cardinals history.

Before becoming Arizona's head coach, Whisenhunt spent two seasons as the Pittsburgh Steelers offensive coordinator, helping the team to a victory over the Seattle Seahawks in Super Bowl XL.

He takes over a San Diego offense that ranked 31st in total offense (297.3 yards per game) in 2012. The only team that finished lower than the Chargers was Arizona (263.1 yards per game).