Chelsea Handler has made it no secret that she is hardly a fan of Angelina Jolie, but the comedienne is now slamming the newly-engaged Oscar winner once again the May issue of More magazine.

The Chelsea Lately host, 37, was asked by the magazine who she thought was "the opposite of a girl's girl."

Handler, who has called Jolie a “home wrecker” in the past, and who is famously best friends with Pitt’s ex-wife Jennifer Aniston, responded "probably Angelina Jolie."

She went on to explain, "[Jolie] doesn't strike me as someone I would have a close friendship with. You just know as a woman, when you see another woman, if that's a woman you can trust."

During a stand-up routine in New Jersey in 2010, Handler was a bit more aggressive in her approach to portray her feelings about the In the Land of Blood and Honey star and mother of six.

“[Jolie] can rescue as many babies from as many countries as she wants to. I don't f**king believe you ... she gives interviews, 'I don't have a lot of female friends.' Cause you're a f**king c**t ... you're a f**king b***h,” she said at the time, AceShowBiz reports.

Despite her disregard for Jolie, Handler also spoke about her own relationship in the magazine. She said she and her boyfriend Andre Balazs just got back together, “literally yesterday.”

She said they “had dated for nine months,” but it was long distance and it wasn’t “a real life.”

"So, Andre came to me yesterday and said, 'I think we have to try to make this work again.' And I agreed because we're still madly in love,” she revealed.