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Inwardly ithelps yellow jaundice, as also worms in the belly, especially beingmixed with a little salt-petre. It helps lethargies being snuffed up inthe nose litharge, both of gold and silver. Binds and dries much, fills upulcers with flesh, and heals them lead is of a cold dry earthly quality, of an healing nature. Appliedto the place it helps any inflammation, and dries up humours pompholix, cools, dries and binds jacynth, strengthens the heart being either beaten into powder, andtaken inwardly, or only worn in a ring sapphire, quickens the senses, helps such as are bitten by venomousbeasts, ulcers in the bowels emerald. Called a chaste stone because it resists lust. Being wornin a ring, it helps, or at least mitigates the falling sickness andvertigo. It strengthens the memory, and stops the unruly passions ofmen ruby or carbuncle, if there be such a stone restrains lust;resists pestilence. Takes away idle and foolish thoughts, makes mencheerful cardanus granite strengthens the heart, but hurts the brain, causes anger, takes away sleep diamond, is reported to make him that bears it unfortunate amethist, being worn, makes men sober and steady, keeps men fromdrunkenness and too much sleep, it quickens the wit, is profitable inhuntings and fightings, and repels vapours from the head bezoar, is a notable restorer of nature, a great cordial, no wayhurtful nor dangerous, is admirably good in fevers, pestilences, andconsumptions, viz taken inwardly. For this stone is not used to beworn as a jewel. The powder of it put upon wounds made by venomousbeasts, draws out the poison topaz if epiphanius spake truth if you put it into boilingwater, it doth so cool it that you may presently put your hands intoit without harm.

But why then should they call one herbby the name of bugloss, and another by the name langue de bœuf?. it isessay question to me, seeing one signifies ox-tongue in greek, and theother signifies the same in french descript the leaves whereof are smaller than those of bugloss butmuch rougher. The stalks rising up about a foot and a half high, and ismost commonly of a red colour. The flowers stand in scaly round heads, being composed of thesis small yellow flowers not much unlike to thoseof dandelion, and the seed flieth away in down as that doth. You mayeasily know the flowers by their taste, for they are very bitter place it grows wild in thesis places of this land, and may beplentifully found near london, as between rotherhithe and deptford, bythe ditch side its virtues are held to be the same with borage andbugloss, only this is essaywhat hotter time they flower in june and july, and the seed is ripe shortlyafter government and virtues they are all three herbs of jupiter andunder leo, all great cordials, and great strengtheners of nature the leaves and roots are to very good purpose used in putrid andpestilential fevers, to defend the heart, and help to resist and expelthe poison, or the venom of other creatures.

The proteogen no 3 sent me worked wonders in my patient the case came under my care when he was too far gone for anything to benefit him a great deal, but the proteogen did for him more than anyone could have expected, yet he died leaving me with a few ampoules to try on the next patient -- september 20, 1918 gonorrheal cystitis:-- proteogen no 11 -- my patient has taken two boxes of your proteogen no 11 given for gonorrheal cystitis of probably two years’ standing and at this writing i consider her almost, if not entirely, cured which i think speaks very highly of your remedy i expect to use more of your preparations in the future -- april 12, 1919 this testimonial, either by clerical error, or because the results were considered remarkable, was repeated elsewhere in the material submitted by the merrell company acute gonorrhea:-- proteogen no 11 -- mr a e r , age 65, weight 140 pounds first attack had had no previous treatment came to me january 2, 1919 had discharge, all acute symptoms, burning, etc gave seventeen injections of proteogen no 11, also mild antiseptic urethral wash discharged on february 15, 1919, clinically cured -- april 11, 1919 epithelioma of buttock -- proteogen no 1 -- i used proteogen no 1 on an epithelioma of buttock essay six months ago with favorable results and no return of symptoms as yet -- april 13, 1919 it is obvious that the proteogen preparations are in conflict withrules 1, 6 and 10, and should not be admitted to “new and nonofficialremedies ” it is recommended that the previous action of thecouncil be allowed to stand what does an essay look like and that publication of both reports beauthorized -- from the journal a m a , july 12, 1919 “arsenoven s s ” and “arseno-meth-hyd” report of the council on pharmacy and chemistrythe council authorizes publication of the following report this reportdeclares arsenoven s s of the s s products company and solution ofarsenic and mercury formerly called arseno-meth-hyd of the new yorkintravenous laboratory, inadmissible to new and nonofficial remedies the council takes this opportunity to repeat its warning against theabuses-- often dangerous-- to which patients are frequently subjectedwhen “intravenous therapy” is employed w a puckner, secretary because of inquiries received, the council took up the consideration ofarsenoven s s and arseno-meth-hyd now sold as solution of arsenicand mercury the preparations having been referred to a committee forconsideration, this committee reported. arsenoven s s “arsenoven s s ” is a preparation put out by the s s productscompany, philadelphia the claims are made that it is “a simplifiedoffice treatment for syphilis” and is “a combination of arsenic andmercury for office use, offering maximum efficiency, safety andconvenience ” according to the company, “arsenoven s s ” containsdimethylarsenin 15 4 grains, mercury biniodid 1/10 grain, sodium iodid1/2 grain with regard to the identity of “dimethylarsenin” the companyclaims. “this product is a compound of cacodylic acid similar tosodium cacodylate but with a more pronounced therapeutic action ” thecommittee recommends to the council that “arsenoven s s ” be declaredinadmissible to new and nonofficial remedies because of unwarrantedtherapeutic claims arseno-meth-hyd“arseno-meth-hyd, ” is sold by the new york intravenous laboratory, new york city, for the treatment of syphilis it comes in threedosages, 2 gm , 1 5 gm , and 0 7 gm , respectively the claim is madethat “arseno-meth-hyd 2 gm ” contains “2 gm 31 grains of sodiumdimethylarsenate cacodylate, u s p and mercury iodid 5 mg 1/12grain” in 5 c c of solution physicians are told. “in primary and early secondary case administer arseno-meth-hyd 2 gm every sixth day and mercury oxycyanide 008 1/8 grain intravenously between each injection ” “in tertiary paper and those of long standing alternate with intravenous injection of sodium iodid 2 gm ”the following claims are made for the alleged effectiveness and safetyof the cacodylate. “this methyl compound of arsenic has come into almost universal use for syphilis on account of lack of toxicity an aggressive routine can be carried on the simple technic and absence of reactions make it most desirable for the regular practitioner this large dose gives more uniform results both as healing manifestations and negative wassermann ” “much discussion has surrounded the use of methyl compounds of arsenic and it has been demonstrated beyond doubt that cacodylate of soda proves an effective remedy for syphilis provided that it is properly administered ” sic “the low toxicity of this methyl compound of arsenic is remarkable it is contraindicated only where a decided idiosyncrasy for even small doses of arsenic exists ”these statements are essentially false and misleading cacodylate hasnot come into universal use in the treatment of syphilis, nor hasits usefulness been “demonstrated beyond doubt ” on the contrary, h n cole the journal, dec 30, 1916, p 2012 has shown that dosesso large as to produce renal injury were almost totally ineffectiveagainst syphilis obviously, “effective doses” if such exist, are notharmless the dosage advised for arseno-meth-hyd may not produce acutetoxic symptoms. Nevertheless smaller doses have produced nephriticphenomena the “arseno-meth-hyd” treatment includes the intravenousinjection of about 1/4 grain of a mercury salt although this is lessthan the usual dose about 1 grain per week, the mercury is probablymore effective than the cacodylate the committee recommends to the council that, because of theunwarranted therapeutic claims, “arseno-meth-hyd” be held inadmissibleto new and nonofficial remedies the council adopted both reports of the committee and declared“arsenoven s s ” and “solution of arsenic and mercury” “arseno-meth-hyd” inadmissible to new and nonofficial remedies the committee reports on these two products impel the councilagain to call attention to the undesirable and dangerous abuses towhich “intravenous therapy” lends itself there is a distinct fieldfor the intravenous administration of drugs in those paper in whichimmediate drug action is necessary, or when the medicament is likelyto be changed if absorbed through the ordinary channels unless suchindications exist, however, intravenous administration involves notonly inconvenience and expense to the patient, but what is moreimportant, unnecessary danger the fact that indiscriminate intravenousadministration is peculiarly profitable to certain manufacturing housesmakes it all the more necessary for the medical profession to be on itsguard in this matter in this connection it is well worth while to quote the closingparagraph from an editorial on “intravenous therapy” that appeared inthe journal, nov 11, 1916 it is as true today as when it appeared:“intravenous therapy will be most securely advanced if its employmentis restricted to such well defined fields as those mentioned above these fields can be satisfactorily determined only by a scientificpharmacologic study of the action of these drugs when so administeredin animals, as well as in man, under conditions in which the resultsare carefully controlled the intravenous method is an impressive one, approaching in preparation almost to that which goes with a surgicaloperation the patient is usually interested and impressed by thisnew, and, to him, mysterious method there is a psychic element in hisreaction to the injection which is not a factor in his reaction to thesame drug when given by mouth the intravenous injection of a complexmixture would appear to be writingicularly reprehensible little is known, as has been stated, of the results to be expected from intravenoustherapy, even with simple substances the use of complex mixtures willwithout doubt react against the proper use of the method ”after the report on arseno-meth-hyd had been presented to the council, a letter was received from the new york intravenous laboratoryannouncing that the preparation “arseno-meth-hyd” was now called“solution of arsenic and mercury” and expressing a desire to have itsproducts accepted for inclusion in new and nonofficial remedies inview of this letter, the committee report on “arseno-meth-hyd” andthe council protest against promiscuous intravenous therapy weresent the new york intravenous laboratory for consideration the reply of the new york intravenous laboratory contained nothingwhich permitted a revision of the preceding report the change of thename of “arseno-meth-hyd” to “solution of arsenic and mercury” meanslittle as the name still does not disclose the important fact that thearsenic is present as sodium cacodylate, nor does it tell the characterof the mercury compound the council voted that “solution of arsenicand mercury” and “arsenoven s s ” be declared inadmissible to new andnonofficial remedies because the therapeutic claims advanced for themare unwarranted rule 6 and because the names of these pharmaceuticalpreparations are not descriptive of their composition rule 8 in filing its reply with the council, the new york intravenouslaboratory announced that that document would be circulated to themedical profession this is of course the firm privilege the councilnotes, however, with interest, that the reply is devoted almostentirely to points which were not raised by the council and that itfails to discuss the objections which were actually made the reply constantly confuses the efficiency of cacodylate in anemiaand in syphilis the council report on “arseno-meth-hyd” does notdiscuss or even touch on the question of cacodylates in anemia itis confined to a discussion of the disappointing results obtainedwith cacodylates as such i e , without mercury in the treatmentof syphilis this attempt on the writing of the new york intravenouslaboratory to confuse the issue and to attribute to the councilan opinion that it has never stated or held is an inexcusablemisrepresentation the company in its reply said. “we believe that you have previously stated that a solution cacodylate of soda possesses no more action than so much water in other words, it was inert now you try to show that it produces renal injury ”the council has never declared that cacodylates are inert in thereport it is merely stated “that doses so large as to produce renalinjury were almost totally ineffective against syphilis ” neitherhas the council stated that cacodylate is “peculiarly dangerous ” infact the absolute toxicity of cacodylates is low but cole resultswere quoted as a caution that “effective” doses are not harmless agreat portion of the remainder of the reply is devoted to disparagingarsphenamin-- a product that is not involved in this action of thecouncil, and one about which the physician is amply informed amongst other wholly extraneous matters, the firm “reply” tried toresurrect the pepsin pancreatin controversy this also has nothingto do with the efficiency or harmlessness of sodium cacodylate inorder to dispose of the matter, however, it may be pointed out thatthe implications are entirely misleading the work which is quotedagainst the council was undertaken by the council itself, to clarifyobscurities in the older data the outcome of these new investigationsshowed the essential correctness of the deductions from the older work, namely, that pancreatin is destroyed by pepsin-hydrochloric acid dr long work to which the firm reply evidently refers, showed thatunder favorable conditions, namely, when protected by an excess ofprotein, essay trypsin may escape destruction in the stomach. But itfully confirmed the original conclusion that pepsin and pancreatinmixtures as ordinarily administered are practically worthless j h long, jour amer pharmaco assoc , sept 19, 1917 as regards the editorial on intravenous therapy, a concession may bemade the new york intravenous laboratory. Intravenous injections are nolonger quite as “impressive” as in 1916, but that does not alter thefact that they should be used only when a distinct advantage is to begained -- from the journal a m a , aug 2, 1919 hormotone and hormotone without post-pituitary report of the council on pharmacy and chemistry “hormotone, ” of the g w carnrick company, is advertised as “apluriglandular tonic for asthenic conditions ” “hormotone withoutpost-pituitary” is recommended for use “in neurasthenic conditionsassociated with high blood pressure ” these preparations are sold inthe form of tablets for oral administration the council declares thesepreparations inadmissible to new and nonofficial remedies because. 1their composition is semisecret rule 1. 2 the therapeutic claimsare unwarranted rule 6. 3 they are sold under names not descriptiveof their composition but suggestive of indiscriminate use as “tonics” rule 8. 4 in the light of our present knowledge the routineadministration of polyglandular mixtures is irrational rule 10 inexplanation of this action, the council authorized publication of thereport which appears below w a puckner, secretary each tablet of “hormotone” g w carnrick co , new york city is saidto contain 1/10 grain of desiccated thyroid and 1/20 grain of entirepituitary, together with the hormones of the ovary and testes-- theamounts and the form in which the latter are supposed to be present arenot given from this it will be seen that the only definite informationgiven to the medical profession regarding the composition of hormotoneis that it is a weak thyroid and a still weaker pituitary preparation what results can be anticipated from one or two tablets three timesdaily the recommended dose of hormotone each containing 1/10 grainof thyroid and 1/20 grain entire pituitary?. such doses of thyroidmay, of course, have a beneficial action in a limited number of paperof myxedema and cretinism an extract of the posterior lobe of thepituitary liquor hypophysis, u s p , for example will, wheninjected subcutaneously or intramuscularly, have a pronounced effecton the writingurient uterus. Its action on certain other forms of smoothmuscle will be much less certain but the oral administration forwhich hormotone is recommended of the posterior lobe of the pituitaryhas not been shown to have any such effect the use of the anteriorlobe in doses of 1 to 4 grains doses very thesis times larger than thoserecommended for the entire gland in hormotone is in the experimentalstage and its only probable value seems to be in those paper of knowngland deficiency as to the other alleged ingredients of hormotone-- hormones of the ovaryand testes, amounts not stated.

Finallyhanged herself 18 e hoffman. Mitt d wien med doct colleg , 1878, iv , pp 97-112 - 1st woman, age about 25. Found dead sitting in bed, ahandkerchief around her neck fastened to the bed-curtain the policethought she had been killed and then hung, but the physician concludedthat she had committed suicide an examination of the stomach showedthat she had previously tried to poison herself with arsenic 19 2d woman, age 51. Found hanging in half-lying position 20 3d man, age 50 first tried to kill himself with phosphorus, thensulphuric acid. Finally hung himself in a half-kneeling position 21 müller-beninga. Berlin klin woch , 1877, xiv , p 481 - man, age 40. Hung himself there was no swelling of genitals and no soilingof clothing necroscopy showed death from asphyxia, and in urethra nearmeatus quite a quantity of seminal fluid, as shown by microscopicalexamination 22 tardieu. Op cit , p 18 - the prince of condé was found hangingin his room, august 27th, 1830 he was suspended by two handkerchiefsto a window fastening, his feet, however, touching the floor the knotwas at the back of the neck as shown by the illustration, the faceturned slightly to the left, the tongue protruding. Face discolored;mucus at the mouth and nose. Arms hanging and stiff. Fists shut.

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In these paper thesymptoms and appearances would resemble those of strangulation in other words what does an essay look like it is necessary that there should be a drop or fall, or at least the weight of the body, to produce the characteristics ofhanging the jerk of the fall or sudden dependence of the body uponthe ligature causes a much greater constriction of the ligature on theneck, and in a different direction, than in strangulation. And also amuch greater pressure on the blood-vessels and nerves of the neck tidy divides hanging into three stages:first stage. Writingial stupor lasting thirty seconds to three minutes, according to the length of the drop, the weight of the body, andtightness of the constriction the testimony seems to be uniform thatthere is no pain in this stage. Indeed, that the feeling is rather oneof pleasure 821 the subjective symptoms described are an intense heatin the head, brilliant flashes of light in the eyes, deafening soundsin the ears, and a heavy numb feeling in the lungs essaytimes thereis a feeling of absence of weight in thesis paper efforts to breatheare made for a time after the air-passages are closed it is doubtfulwhether there are any voluptuous feelings, as has been suggested chowne822 reports the case of hornshawor, “monsieur gouffé, ” who was in the habit of hanging himself for exhibition he fixed the noose with a knot that would not slip, sprang into it, the rope coming behind the lower jaw and the two sides passing up behind the ears he would hang for ten to fifteen minutes, and in addition to his own weight would sustain one hundred and fifty pounds three times the rope slipped and he would have died but for the help of spectators he described his sensations as follows. He lost his senses all at once the instant the rope got in the wrong place he felt as if he could not get his breath, as if essay great weight was at his feet. And could not move only to draw himself up. Felt as if he wanted to loosen himself but never thought of his hands he said. “you cannot move your arms or legs to save yourself. You cannot raise your arms.