Variability of Automated Shape Analyses of Fixed Brain Mouse MRI

Tsatskis S, Lerch J, Sled J, Kovacevic N, Henkelman R

Mouse Imaging Centre

The study of phenotype/genotype relationships can be performed rapidly and accurately using high-resolution MRI on inbred mouse models. This abstract investigated the variability of an automated non-linear registration based shape analysis framework in 32&[micro]m fixed brain MRI, where the mouse brains remained inside the skull in order to reduce shape changes due to specimen handling. We found lower variance and higher statistical power using this improved protocol when compared to previous results.