Archives

Follow us on Twitter

Category: antioxidants & redox signaling

A group of smoking researchers — no, not scientists who are on fire; scientists who study the effects of tobacco smoke — has retracted a 2009 article after deciding that they were no longer “satisfied with the quality of the data.”

The paper, “Cigarette Smoke–induced Oxidative/Nitrosative Stress Impairs VEGF- and Fluid Shear Stress–Mediated Signaling in Endothelial Cells,” came from the lab of Irfan Rahman, a lung disease expert at the University of Rochester. It appeared online in 2009 in Antioxidants & Redox Signaling, which will be familiar to readers watching the case of Dipak Das.

We’ve now learned that the investigation has grown to 25 papers after an anonymous whistleblower warned about possible data fabrications in another paper by Kang, an associate professor of veterinary biotechnology, and Kyung-Sun Kang, director of the Adult Stem Cell Research Center in the same department (but no relation). And Soo-Kyung Kang was investigated in 2010, according to the Korea Herald.

In a case that is a good reminder of why journal editors shouldn’t ignore anonymous tips, a Seoul National University stem cell researcher has been forced to retract four papers, and withdraw another under peer review, in Antioxidants & Redox Signaling following a whistleblower’s exhaustive analysis.

Two retractions by Soo Kyung Kang, a professor of veterinary biotechnology at Seoul National University, appeared on May 9 after an anonymous whistleblower sent a 70-slide PowerPoint presentation to the editors of ten journals that contained evidence of suspicious floating error bars, errors larger than actual measurements, pasted-together lanes in PCR gels and RNA and CHIP blots and several cases where the same control blot data is shown across different experiments and in different papers. In all, the whistleblower raises questions about 14 papers in the ten journals.

Antioxidants & Redox Signalling has issued much more detailed retraction notice for a paper it pulled last year that was marred by duplicate data.

As we reported then, the journal’s initial notice for the 2011 article, titled “Inhibition of LXRa-dependent steatosis and oxidative injury by liquiritigenin, a licorice flavonoid, as mediated with Nrf2 activation,” was underwhelming:

THIS WORK HAS BEEN RETRACTED BY THE AUTHORS

Although we learned at the time that a reader, Paul Brookes, of the University of Rochester, had raised concerns about the article to the editors of ARS and other publications, we were glad to see that ARS has decided to make a clean breast of matters. The study has been cited by other papers three times, according to Thomson Scientific’s Web of Knowledge.

In the wake of the massive allegations of fraud by resveratrol researcher Dipak Das, other researchers in the field are clearly trying to distance themselves from the University of Connecticut scientist. Nir Barzilai told us yesterday, for example, that despite Das seemingly’ impressive publication record, “Rome was not built on Dr. Das.”

Many Retraction Watch readers will now be familiar with the case of Dipak Das, the resveratrol researcher about whom the University of Connecticut issued a voluminous report yesterday — summary here — detailing 145 counts of data fabrication and falsification. This has been a fast-moving story, so we wanted to highlight a number of updates to our original post, and offer a few more.

There’s an unhelpful retraction notice online in the journal Antioxidants & Redox Signaling, a Mary Ann Liebert publication. The paper, “Inhibition of LXRalpha-dependent steatosis and oxidative injury by liquiritigenin, a licorice flavonoid, as mediated with Nrf2 activation,” has been removed from the site, except for the abstract, which now has this in front of it:

THIS WORK HAS BEEN RETRACTED BY THE AUTHORS

That, as we’ve said before in exasperation, certainly clears things right up.