Mission: To be a resource for transplant information; to be an advocate for organ & tissue donation awareness; to promote funding for transplant research.

Thursday, March 29, 2012

Growing organs for transplants

Regenerative Medicine has exciting possibilities for the future of medicine as scientists are learning to use stem cells to replace defective cells and attempt to restore normal function in a wide range of organs. I had the privilege of taking a tour of the McEwen Centre for Regenerative Medicine in Toronto and seeing this research first hand.

At any given time there are up to 86-thousand people worldwide waiting for donor organ. Until researchers can make regenerative medicine reality, you can make a difference by being an organ donor."

By Dr. Jay Adlersberg
NEW YORK (WABC) -- Organ transplants have progressed rapidly in recent years, but organ recipients still need medication to suppress the immune system.

One exception is a transplant between identical twins and that's presenting researchers with an exciting goal.

It sounds like something out of science fiction, but it's happening right in our lifetime, and you will be hearing more and more about it.

The solution to finding a organ like one that might come from an identical twin is to grow one, and that field is called regenerative medicine.
It was just about a year ago that Ernesto Boleaga learned his symptoms - fatigue, anemia and swollen feet were caused by severe kidney failure. He would need a transplant. His twin brother's response was immediate.

"I have two kidneys. I said, 'If I can give you one of my two kidneys, please take it,'" Jose Luis Boleaga said.

Because they're identical twins, the brothers have the same genetic makeup, so Ernesto's body accepts his brother's kidney as its own.

Ernesto's immune system won't reject it as it would one from an unrelated donor.

For most people, drugs that suppress the immune system help stop the rejection process. But they cause side effects, and over time, the body's immune system "wins" and damages the new kidney.

"I think the challenge today is how do you make that organ last for a lifetime?"Mikel Prieto, M.D., Mayo Clinic transplant surgeon, said.

The answer may be in regenerative medicine that is, reproducing an organ that is essentially genetically identical to the patient getting it.

Right now, researchers in the lab are able to turn stem cells into other cells such as kidney cells. The hope is that one day they will be able to grow those cells into life saving organs for people like Ernesto.

"We hope that sometime in the future we will be able to reproduce an organ that is essentially genetically identical to the patient getting it. When we achieve that, then basically every transplant will be like doing a transplant between identical twins," Prieto said.

At any given time there are up to 86-thousand people worldwide waiting for donor organ. Until researchers can make regenerative medicine reality, you can make a difference by being an organ donor.

“You Have the Power to Donate Life – to become an organ and tissue donor Sign-up today!
Tell Your Loved Ones of Your Decision”

Your generosity can save or enhance the lives of up to fifty people with heart, kidneys, liver, lungs, pancreas and small intestine transplants (see allotransplantation). One tissue donor can help by donating skin, corneas, bone, tendon, ligaments and heart valves

Has your life been saved by an organ transplant? "Pay it forward" and help spread the word about the need for organ donation - In the U.S. another person is added to the national transplant waiting list every 11 minutes and 18 people die each day waiting for an organ or tissue transplant. Organs can save lives, corneas renew vision, and tissue may help to restore someone's ability to walk, run or move freely without pain. Life Begins with You.