GREMLIN Results:
Residue pairs sorted by strength in covariance:Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

i

j

Raw Score

Scaled Score

153_G

160_T

0.58393

4.901

120_F

152_M

0.3705

3.110

143_G

149_D

0.29018

2.436

140_A

161_I

0.2641

2.217

42_K

138_E

0.25972

2.180

99_E

103_K

0.24868

2.087

124_L

139_I

0.22723

1.907

20_H

154_N

0.22716

1.907

69_N

73_K

0.21692

1.821

142_I

161_I

0.21027

1.765

48_K

82_I

0.19052

1.599

118_G

122_E

0.18789

1.577

31_F

71_L

0.18429

1.547

82_I

102_E

0.18213

1.529

45_I

141_V

0.18072

1.517

47_D

51_T

0.17982

1.509

17_L

151_L

0.17357

1.457

65_A

69_N

0.17355

1.457

86_S

98_A

0.1704

1.430

123_I

152_M

0.16948

1.423

43_A

129_C

0.16892

1.418

31_F

67_W

0.16886

1.417

129_C

139_I

0.16714

1.403

124_L

136_P

0.16592

1.393

41_I

140_A

0.15924

1.337

85_N

117_P

0.15682

1.316

23_V

29_I

0.15548

1.305

66_E

70_E

0.15205

1.276

48_K

120_F

0.15168

1.273

46_F

142_I

0.15139

1.271

24_P

28_D

0.15008

1.260

30_D

33_A

0.1474

1.237

46_F

80_V

0.14643

1.229

151_L

155_R

0.14394

1.208

43_A

127_F

0.14372

1.206

106_G

128_K

0.14234

1.195

150_V

160_T

0.14101

1.184

120_F

141_V

0.14061

1.180

122_E

126_Y

0.14051

1.179

37_K

74_Q

0.13607

1.142

69_N

72_K

0.13524

1.135

62_P

66_E

0.13506

1.134

68_L

107_I

0.13354

1.121

37_K

42_K

0.13346

1.120

80_V

115_K

0.13332

1.119

21_L

140_A

0.13308

1.117

86_S

102_E

0.13278

1.115

69_N

103_K

0.13081

1.098

26_I

64_Y

0.1292

1.084

38_K

73_K

0.12846

1.078

70_E

73_K

0.12816

1.076

57_E

60_I

0.12753

1.070

80_V

107_I

0.12742

1.070

48_K

98_A

0.1266

1.063

48_K

145_R

0.1261

1.058

95_G

99_E

0.12564

1.055

33_A

39_K

0.12526

1.051

141_V

158_S

0.12267

1.030

54_P

61_P

0.1224

1.027

33_A

107_I

0.12053

1.012

29_I

44_L

0.12022

1.009

95_G

113_R

0.11993

1.007

77_K

127_F

0.11925

1.001

73_K

125_K

0.11828

0.993

33_A

140_A

0.118

0.990

95_G

112_H

0.11785

0.989

38_K

128_K

0.11779

0.989

103_K

137_S

0.11721

0.984

121_R

125_K

0.11631

0.976

68_L

80_V

0.11603

0.974

117_P

153_G

0.11563

0.971

73_K

136_P

0.11532

0.968

60_I

101_L

0.11472

0.963

36_L

160_T

0.11441

0.960

145_R

148_T

0.11424

0.959

26_I

162_L

0.11404

0.957

82_I

156_M

0.11403

0.957

32_E

74_Q

0.11402

0.957

62_P

73_K

0.11391

0.956

125_K

137_S

0.11382

0.955

50_N

145_R

0.11299

0.948

19_P

50_N

0.1128

0.947

45_I

127_F

0.1128

0.947

54_P

57_E

0.11241

0.944

32_E

38_K

0.11169

0.938

126_Y

137_S

0.11152

0.936

102_E

107_I

0.11076

0.930

121_R

139_I

0.11036

0.926

72_K

137_S

0.10994

0.923

58_D

101_L

0.10922

0.917

97_R

114_A

0.1092

0.917

86_S

145_R

0.10819

0.908

21_L

33_A

0.10779

0.905

44_L

140_A

0.10747

0.902

112_H

118_G

0.10654

0.894

38_K

69_N

0.10594

0.889

81_L

110_L

0.10446

0.877

76_G

145_R

0.1043

0.875

38_K

63_E

0.10401

0.873

120_F

123_I

0.10323

0.867

70_E

74_Q

0.10266

0.862

31_F

41_I

0.1023

0.859

33_A

38_K

0.1021

0.857

53_T

101_L

0.10207

0.857

37_K

73_K

0.10197

0.856

86_S

97_R

0.10154

0.852

61_P

65_A

0.1015

0.852

154_N

160_T

0.10094

0.847

62_P

108_P

0.10028

0.842

153_G

159_Y

0.09951

0.835

62_P

104_A

0.09943

0.835

86_S

114_A

0.09931

0.834

71_L

139_I

0.09918

0.833

96_E

103_K

0.09886

0.830

136_P

157_G

0.09867

0.828

19_P

47_D

0.0977

0.820

83_V

146_L

0.097

0.814

45_I

51_T

0.09651

0.810

118_G

125_K

0.09552

0.802

50_N

148_T

0.09544

0.801

140_A

159_Y

0.09505

0.798

32_E

106_G

0.09469

0.795

85_N

144_D

0.09413

0.790

64_Y

156_M

0.09397

0.789

96_E

113_R

0.0939

0.788

75_F

145_R

0.09301

0.781

20_H

159_Y

0.09291

0.780

124_L

156_M

0.09281

0.779

72_K

99_E

0.09273

0.778

141_V

152_M

0.09264

0.778

49_D

148_T

0.09257

0.777

32_E

72_K

0.09239

0.776

27_R

75_F

0.09221

0.774

73_K

106_G

0.09194

0.772

28_D

137_S

0.09174

0.770

47_D

52_L

0.09169

0.770

47_D

50_N

0.09158

0.769

46_F

67_W

0.09137

0.767

118_G

155_R

0.0912

0.766

85_N

149_D

0.09116

0.765

62_P

65_A

0.09106

0.764

21_L

159_Y

0.09105

0.764

53_T

60_I

0.09086

0.763

24_P

164_T

0.09052

0.760

107_I

113_R

0.09012

0.756

129_C

138_E

0.08995

0.755

51_T

145_R

0.08991

0.755

97_R

111_R

0.08901

0.747

47_D

145_R

0.08897

0.747

119_C

153_G

0.08883

0.746

83_V

143_G

0.08858

0.744

61_P

82_I

0.08794

0.738

80_V

102_E

0.0878

0.737

30_D

38_K

0.08775

0.737

97_R

152_M

0.08771

0.736

126_Y

129_C

0.08771

0.736

28_D

128_K

0.0877

0.736

67_W

114_A

0.08719

0.732

57_E

96_E

0.08668

0.728

36_L

40_G

0.08651

0.726

81_L

160_T

0.08643

0.725

103_K

125_K

0.08642

0.725

72_K

80_V

0.0863

0.724

49_D

144_D

0.08614

0.723

44_L

71_L

0.08584

0.721

42_K

139_I

0.08569

0.719

55_P

86_S

0.08568

0.719

20_H

164_T

0.08537

0.717

69_N

106_G

0.08478

0.712

28_D

73_K

0.08471

0.711

18_L

157_G

0.08404

0.705

68_L

100_A

0.08373

0.703

105_L

150_V

0.08367

0.702

98_A

102_E

0.08343

0.700

48_K

51_T

0.083

0.697

119_C

126_Y

0.08244

0.692

85_N

148_T

0.08234

0.691

44_L

51_T

0.08209

0.689

148_T

154_N

0.08202

0.688

57_E

103_K

0.08171

0.686

58_D

139_I

0.08166

0.685

84_S

98_A

0.08065

0.677

67_W

86_S

0.08049

0.676

84_S

145_R

0.08044

0.675

38_K

65_A

0.08027

0.674

80_V

105_L

0.08026

0.674

83_V

123_I

0.08024

0.674

150_V

161_I

0.08022

0.673

73_K

76_G

0.08001

0.672

81_L

126_Y

0.08

0.672

102_E

109_V

0.07998

0.671

40_G

54_P

0.07993

0.671

77_K

122_E

0.07992

0.671

36_L

51_T

0.07991

0.671

110_L

120_F

0.07974

0.669

141_V

150_V

0.07973

0.669

51_T

97_R

0.07959

0.668

Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.

HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits: Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)