Machete Kills is the sequel to the 2010 hit film Machete – which has built a devoted legion of fans since its release – and is the second film in a trilogy. The film is produced by Robert Rodriguez, along with Aaron Kaufman and Iliana Nikolic through their QuickDraw Productions banner, as well as Sergei Bespalov of Aldamisa Films, Alexander Rodnyansky of AR Films, and Rick Schwartz of Overnight Films.

In Machete Kills, Danny Trejo returns as ex-Federale agent Machete, who is recruited by the President of the United States for a mission which would be impossible for any mortal man – he must take down a madman revolutionary and an eccentric billionaire arms dealer who has hatched a plan to spread war and anarchy across the planet.