In 1974, Wesley Eure tried out for and won a role on NBC's Days of Our Lives. Eure had previously met producer Sid Krofft and was committed to do an audition for a new children's show he was working on. Eure auditioned and won the role of Will Marshall on Land of the Lost. He kept his commitment to both shows.

From 1974 to 1981, Eure starred on NBC's Days of Our Lives, playing the role of Mike Horton. He also starred as Will Marshall in Sid and Marty Krofft's children's adventure series, Land of the Lost from 1974 to 1976, filming this show and Days of Our Lives simultaneously. Eure agreed to be billed simply as ''Wesley'' on Land of the Lost.

Eure's stardom in the 1970s led to a number of appearances on game shows. He was repeatedly asked to appear on both Password and Match Game. He appeared on Password so often that he became a semi-regular on the show.

He later appeared in Hanna-Barbera's 1979 comedy C.H.O.M.P.S, which also starred Valerie Bertinelli, Red Buttons, Jim Backus, Hermione Baddeley, and Conrad Bain.

In 1987, Eure became host of the Nickelodeon children's game show Finders Keepers, and continued in this role through 1988.

Eure co-produced, wrote and acted in Fox Television's hidden-camera shows Totally Hidden Video (which aired from 1989 to 1992). He also co-created Dragon Tales, PBS Kids's Emmy-nominated animated series for preschoolers which began airing in 1999, and directed Spy TV for NBC in 2001.