"Californication" is the Red Hot Chili Peppers' fourth single and sixth track from their 1999 seventh studio album, Californication. Released as a single in 2000, the song reached #69 on the Billboard Hot 100 in the USA, and #16 on the UK charts, and hit #1 on both US Mainstream Rock Tracks for 2 weeks and US Modern Rock Tracks for 1 week.

"Californication" has remained one of the band's most popular and most performed live songs appearing in almost every setlist since its live debut making it the band's fourth most performed song with over 490 performances.[1]

Guitarist John Frusciante exclusively recorded this song and "Otherside" with a vintage Gretsch White Falcon hollow body electric guitar; he also played these songs live with the White Falcon until 2006 when he retired it for one of his vintage Fender Stratocasters.

In Kiedis's book, Scar Tissue, the author reveals that the band had enormous difficulty in putting the song together. Kiedis had written the lyrics, which he felt were some of the best he had ever written, but the band could not decide how the song should sound musically. As they struggled with the song it seemed like they would not be able to finish it in time to include it on the album, until one day Frusciante walked into the studio and exclaimed that he had "figured it out". He played the song as he visualised it, and it went from being a song that could have been an afterthought, to becoming one of the Red Hot Chili Peppers' greatest hits, similar to the way "Under the Bridge" was conceived.

The Red Hot Chili Peppers' Greatest Hits album uses a slightly different version of the song. Most notably, the first chorus is extended. The reason for this alternate version's appearance on the album is unknown.

Like most of the singles from the album, "Californication" remains a live staple in the band's setlists and is one of their most performed songs since its release.[3]

The song is performed in the key of A minor with Frusciante picking the chords of Am and F for 12 measures before picking the chords of C-G-F-Dm then going back and picks Am and F for 8 more measures before picking C-G-F-Dm again. For the pre-chorus Frusciante then strums a combination of Am and Fmaj7 chords for 12 measures until the chorus when he strums the chords C-G-Dm-Am then C-G-Dm. After the second chorus a 16-measure guitar solo is played by Frusciante who changes the key to A Major. After the solo, the key goes back to the original A Minor and a third verse and final chorus is played.

The video takes the form of a PC 3D video game from the third-person point of view of each of the band members, all on some sort of adventure; this varies with each band member. John, sporting a similar hairstyle to the Blood Sugar Sex Magik era, runs through Hollywood, dodging celebrities and their bodyguards. Chad snowboards in the Sierra Nevada Mountains, then he falls off a cliff and lands on a train. Anthony swims in the San Francisco Bay, surrounded by sharks and females; he then surfs on a shark's back and suddenly jumps into the front seat of, and drives, a convertible car. Flea runs through Sequoia National Park, saving a bear from a hunter, riding a mining cart, and escaping many lumberjacks as they are cutting down all the trees. John enters a film studio, where he interferes with the productions of a space movie, a pornographic film, and a Leonardo da Vinci biographical documentary. Next Chad rails one of the Golden Gate Bridge's main suspension wires on his snowboard, while Anthony, joyriding across the bridge, passes through the Andy's Donuts doughnut (a thinly-veiled reference to the Randy's Donuts shop); he then drives off a cliff, landing on a giant dragonfly with Flea riding it. In the meantime, Chad skysurfs, and John rides the da Vinci flying machine prop from the studio. Anthony then falls off the dragonfly and lands brutally (losing most of his health in the process) on a giant garden. This scene cuts off into the band passing through an earthquake of the San Andreas Fault, eventually concluding with all four of them meeting at the center of the Earth, where they all touch a 3D cube which transforms their computer-generated avatars back into all four of their own real selves, as the message "Game Over" appears at the bottom of the screen, segueing into a "Next Game?" prompt, upon which the video ends. Intercut with all this is live-action performance footage of the band, which remains in a picture-in-picture insert till a band member passes through the eight-rayed star that became the band's de facto logo symbol when it was first used for the album Mother's Milk; this is enough to make the live-action footage fill the screen each time a band member passes through it.[4] The video itself contains many homages to video games of its time.

The music video is the group's most watched on YouTube, with over 130 million views.