VE-cadherin (IPR030052)

Short name:
CDH5

Overlapping homologous superfamilies

None.

Family relationships

None.

Description

VE-cadherin (vascular endothelial-cadherin) or cadherin-5 (CDH5) belongs to the cadherin family, whose members are transmembrane proteins that serve as the major adhesion molecules located within adherens junctions. CDH5 is essential for endothelial survival [PMID: 10428027] and embryonic development [PMID: 10207135]. It is dispensable for endothelial homophilic adhesion, but is required for vascular morphogenesis [PMID: 10207135, PMID: 9473340].