Useful in the identification of leukemias, plasmacytomas and certain non-Hodgkin’s lymphomas. The most common feature of these malignancies is the restricted expression of a single light chain class. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is clonal and therefore malignant. Immunoglobulin bearing Kappa light chains are present on about 60% of normal B lymphocytes.

Catalog #

K0090-09A

This antibody can be used for detecting surface immunoglobulin on normal and neoplastic B cells in tissues. Extracellular Ig kappa light chains may also be stained. Kappa chain antibodies are useful for the identification of leukemias, some non-Hodgkin’s lymphomas and plasmacytomas.

Applications

Suitable for use in Immunohistochemistry. Other applications have not been tested.

May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Freeze at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Clone Type

Monoclonal

Isotype

IgG1

Clone No

6A101

Host

Mouse

Source

Human

Concentration

As reported

Form

Supplied as a liquid in PBS, pH 7.4, and 1% BSA with 0.05% sodium azide

Purity

Purified from mouse ascites

Immunogen

Human serum

Specificity

Reacts with the kappa light chain of human immunoglobulins irrespective of the Ig isotype. It does not react with the lambda light chain.

Important Note

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.