Author Conclusion:“Among patients with stage 3 CKD undergoing contrast-enhanced computed tomography, withholding prehydration did not compromise patient safety. The findings of this study support the option of not giving prehydration a safe and cost-efficient measure.”

Clinical Take Home Point: There is no benefit of fluid expansion with sodium bicarbonate prehydration vs no prehydration in patients with stage 3 CKD requiring elective IV contrast enhanced CTs. In addition, prehydration is accompanied with significant health care costs and although not shown in this trial could potentially increase adverse effects."