Intermediate Filaments Assembly: • 8–11 nm in diameter, between actin filaments and microtubules in size • Most stable portion of cytoskeleton and most heterogeneous • Components vary with cell type and state of differentiation. • Structure is two coiled coils

Intermediate Filaments • Intermediate filaments are made up of subunits that form extended α-helical rod-like domains • Monomers  dimer • Two dimers  antiparallel tetramer • With 8 bundles making up a fiber.

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Centrosome (Animal Cells) Regulation of MT assembly is under control of a MT organizing center (MTOC): called a centrosome . Centriole – cylindrical array of MT found in center of centrosome

Regulation of MT • all cells have Microtubule Organization Center (MTOC) but not all are organized by centrioles – some centrosomes have no centrioles – some centrosomes organize MTs in cilia, called basal bodies • not same as flagella in bacteria – plants and have centrosomes without centrioles

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