New York Giants wide receiver Odell Beckham Jr. (13) watches from the sidelines during the fourth quarter against the San Francisco 49ers with an injury in an NFL football game, Sunday, Oct. 11, 2015, in East Rutherford, N.J. Photo Credit: AP / Seth Wenig

Tom Coughlin said it is in "the realm of possibility" that the Giants will be without either Odell Beckham Jr. or Rueben Randle -- or possibly both -- when they face the Eagles next Monday night in Philadelphia. Throw in the uncertain status of Victor Cruz and the team may need to add healthy receivers to its roster before the end of the week.

"I hope it doesn't [happen]," Coughlin said, "but we've got a little bit of time here to see how that's going to stack up."

Both Beckham and Randle left the game against the 49ers on Sunday night with hamstring injuries. Beckham returned for the final three offensive snaps. Cruz was scheduled to meet with doctors to gauge the progress from the PRP injection in his ailing calf 10 days ago on Monday. Coughlin said he had not received word on Cruz's availability this week.

If the Giants don't have their "big three" receivers, they'd be left with Dwayne Harris, Myles White and Geremy Davis. That trio has a combined 55 career receptions, 44 by Harris.

"We'll see how fast they respond," Coughlin said, noting the extra day for rehab and recovery this week. "I'm hoping that we can get Odell and Rueben at least on a limited basis for the entire rest of the week. I know that's [optimistic], but I would hope we could do that."