SPOTLIGHT

Development 2020 147: dev178004 doi: 10.1242/dev.178004 Published 27 April 2020

Summary: How much evolutionary change in development do we expect? This Spotlight argues that developmental biologists are in a prime position to provide informed null hypotheses for evolutionary change.

REVIEW

Development 2020 147: dev179069 doi: 10.1242/dev.179069 Published 27 April 2020

Summary: Focussing on recent microscopy-based studies, this Review discusses current understanding of the regulation of Yorkie, YAP and TAZ, which are key transcriptional regulators that act downstream of the Hippo pathway to control cell fate and organ size.

Development 2020 147: dev186569 doi: 10.1242/dev.186569 Published 27 April 2020

Highlighted Article: The transcription-factor Runx1 orchestrates the injury response of many cardiac cell types, balancing collagen and fibrin deposition and clearance, as well as affecting myocyte proliferation and survival in zebrafish.

Development 2020 147: dev184259 doi: 10.1242/dev.184259 Published 12 April 2020

Summary: Single cyst-resolution, genome-wide transcriptional profile analysis of Drosophila testes has offered an unprecedented data resource at each crucial stage of differentiation in an adult stem cell system under physiological conditions.

Development 2020 147: dev184655 doi: 10.1242/dev.184655 Published 12 April 2020

Highlighted Article: mRBPome capture reveals that the RNA-binding protein TRIM71 is expressed by mouse undifferentiated spermatogonial, and conditional knockout of Trim71 uncovers a key role in regulation of spermatogonial differentiation.

Development 2020 147: dev186874 doi: 10.1242/dev.186874 Published 27 April 2020

Summary: Loss of the carboxypeptidase AMP1 does not interfere with the function of miR156 or miR159, suggesting that AMP1 is not universally required for miRNA-mediated translational repression in Arabidopsis.

Development 2020 147: dev185819 doi: 10.1242/dev.185819 Published 27 April 2020

Summary: Reactive oxygen species (ROS) act as developmental signals to drive initiation of root hairs, and the amount and position of ROS accumulation is defined by tissue-specific synthesis of flavonol antioxidants.

Development 2020 147: dev185322 doi: 10.1242/dev.185322 Published 27 April 2020

Summary: Mis12 is required for G2/M transition by regulating cyclin B1 accumulation via Cdc14B-mediated APC/CCdh1 regulation, but is not essential for spindle and chromosome dynamics during meiotic maturation.

Development 2020 147: dev184069 doi: 10.1242/dev.184069 Published 20 April 2020

Summary: This study reveals that kinesin-1 plays a key role in the endocannabinoid signaling that regulates activity at the axonal growth cones of cortical neurons for actin remodeling, axonal pathfinding and brain wiring.

Development 2020 147: dev186130 doi: 10.1242/dev.186130 Published 20 April 2020

Highlighted Article: Vascular tissues are the first to form in the plant embryo. Using a yeast one hybrid assay, we identify that GBF2 acts as a vascular gene expression modulator, via interactions with auxin response factors.

Development 2020 147: dev186841 doi: 10.1242/dev.186841 Published 13 April 2020

Highlighted Article: In adult neurogenesis, PBX1 acts as terminal selector for dopaminergic neuron fate in addition to its known pro-neurogenic role in progenitors. Alternative splicing is important to confer functional diversity to PBX1.

Development 2020 147: dev183723 doi: 10.1242/dev.183723 Published 12 April 2020

Summary: bmo-miR-2739 and novel-miR-167 are coordinately involved in regulating the stage- and tissue-specific expression of BmVgR protein to enable accumulation of yolk protein in oocytes during vitellogenesis.

Development 2020 147: dev183699 doi: 10.1242/dev.183699 Published 12 April 2020

Summary: A dot-stripe Turing mechanism can reproduce a wide diversity of joint patterns observed in the tetrapod lineage, providing a unifying framework to interrogate joint patterning in the tetrapod limb.

Other journals from The Company of Biologists

We are aware that the COVID-19 pandemic is having an unprecedented impact on researchers worldwide. The Editors of all The Company of Biologists’ journals have been considering ways in which we can alleviate concerns that members of our community may have around publishing activities during this time. Read about the actions we are taking at this time.

Please don’t hesitate to contact the Editorial Office if you have any questions or concerns.

Paul François is an Associate Professor at McGill University, Canada and has recently joined the Development team as an Associate Editor. We caught up with Paul over Skype from his home in Montreal, Canada, to find out more about his background and research – and what he is excited about in the field of computational and theoretical biology.

Researchers at nine institutions in Ireland can now publish an unlimited number of Open Access articles in Development, immediately and at no cost to them, following a three-year Read & Publish agreement between The Company of Biologists and IReL. Find out more and see the growing list of participating institutions.