GenAge entry for UBE2I (Homo sapiens)

Gene name (HAGRID: 85)

Potential relevance to the human ageing process

Main reason for selection

Entry selected based on evidence linking the gene product to the regulation or control of genes previously linked to ageing

Description

UBE2I catalyzes the attachment of SUMO1 to other proteins. Although no direct evidence exists to suggest a role for UBE2I in ageing, it is related to, among others, WRN [903] and PCNA [490], suggesting it might play a role in DNA repair and perhaps even in ageing. UBE2I deficiency in mice results in embryonic lethality [1678].