Story at-a-glance -

Drinking alcohol can cause high levels of the breakdown product acetaldehyde to accumulate in your body

Acetaldehyde is up to 30 times more toxic than the alcohol itself and may be responsible for many hangover symptoms

Taking a combination of N-acetyl cysteine (NAC), B vitamins, milk thistle, and vitamin C before you drink may help to stave off a hangover

Staying hydrated, drinking in moderation and only on a full stomach are also important

Hangover remedies to try include bone broth for minerals, coconut water for electrolytes, eggs for natural cysteine, ginger for nausea, and coconut for potassium

By Dr. Mercola

On New Year's Eve, Americans drink more alcohol than on any other day of the year.1 Other top contenders are Christmas, Thanksgiving, the Fourth of July, and St. Patrick's Day… but none top New Year's Eve, for imbibing.

What that means is that New Year's Day, may be the day of the year when you're most likely to suffer from a hangover, which is the conglomeration of symptoms – fatigue, nausea, stomach pain, headaches, shakiness, vomiting, dizziness, and more – that occurs when you've had too much to drink.

The best way to prevent a hangover, of course, is to avoid drinking, or have only one or two cocktails at the most (but be aware that even a single drink can trigger a hangover in some people).

But let's say you tend to get caught up in your celebrations and suspect you might have a few more than you normally do. There are some natural remedies that may help you to avoid hangover symptoms altogether, but the time to take action is now, before you drink.

What Causes a Hangover? 7 Major Biochemical Reactions to Alcohol

Alcohol, and too much of it specifically, triggers a cascade of reactions in your body that contribute to the symptoms known as a hangover. This includes:

1. Increased Urination

Alcohol inhibits the secretion of vasopressin, an antidiuretic hormone that keeps you from urinating unintentionally. When this enzyme is suppressed, water is sent right to your bladder (along with electrolytes) to be excreted, causing you to urinate more often.

2. Dehydration

The increased urination can lead you to become quickly dehydrated, and as your body draws water from your brain to function, it may leave you feeling fatigued or dizzy.

3. Acetaldehyde Build-Up

When alcohol reaches your liver, an enzyme called alcohol dehydrogenase breaks it down into acetaldehyde. Acetaldehyde is far more toxic than alcohol (by up to 30-fold!2).

So your body again attempts to break it down with the enzyme acetaldehyde dehydrogenase and glutathione, a powerful antioxidant that is crucial for liver detoxification (glutathione contains high levels of cysteine, which is why taking this in supplement form may help prevent hangovers… more on this below).

Together, this powerful detox duo can break down the acetaldehyde into harmless acetate (which is similar to vinegar).

However, when you drink too much alcohol, your stores of glutathione become depleted, which allows acetaldehyde to build up in your body, causing the toxic hangover effect.

It should be noted that women have less acetaldehyde dehydrogenase and glutathione than men, which is why women may have a more severe reaction to drinking the same amount of alcohol as a man of similar weight.

4. Congeners

Congeners are ingredients produced as byproducts of fermentation and distillation. They include acetone, acetaldehyde, tannins, and some flavorants in different alcoholic beverages. Congeners are thought to make the effects of a hangover worse and are found in higher amounts in darker liquors (such as brandy, whiskey, and red wine) than clear liquors like vodka or gin.

5. Glutamine Rebound

Alcohol inhibits glutamine, a natural stimulant in your body. This is partly why alcohol has a depressive effect that may make you fall asleep easily… at first. After you've stopped drinking, your body will work overtime increasing glutamine levels, which is why you'll ultimately wake up more often and have a more fitful night's sleep after you drink.

This glutamine rebound may contribute to the fatigue, tremors, anxiety, restlessness, and even increased blood pressure that are often felt during a hangover.3

6. Disruptions to Your Stomach Lining, Blood Vessels, and Blood Sugar

Alcohol is irritating to your stomach lining and leads to an increased production of stomach acid. This can cause nausea, vomiting, and stomach pain. Alcohol can also lead to dips in your blood sugar level, which can lead to shakiness, mood swings, fatigue, and seizures. Also, alcohol may cause your blood vessels to expand, which may trigger headaches.

7. Inflammatory Response

Finally, alcohol also provokes an inflammatory response in your body in which your immune system may trigger agents that provoke hangover symptoms including memory problems, decreased appetite, and trouble concentrating.4

Hangover 'Pre-Tox': Do This Before You Drink

A great example confirming the validity of this approach that you might relate to is if you ever took vitamin C prior to going to the dentist who gave you a local anesthetic to numb your tooth before dental work. You would most likely have noted that the anesthetic did not work at all, took a much larger dose, or wore off quickly. This is because vitamin C accelerates your liver's ability to detoxify it.

Alcohol is a different animal, though, and since it impacts your body on such a wide scale, the more steps you take to circumvent the ill effects, the better. If you know you'll be having a few drinks, take this natural protocol beforehand to help 'pre-tox' your body:

1. N-acetyl cysteine (NAC)

NAC is a form of the amino acid cysteine. It is known to help increase glutathione and reduce the acetaldehyde toxicity5 that causes many hangover symptoms. Try taking NAC (at least 200 milligrams) 30 minutes before you drink to help lessen the alcohol's toxic effects.

If you're wondering just how powerful NAC can be, consider that, like alcohol, one way that Tylenol causes damage to your liver is by depleting glutathione. If you keep your glutathione levels up, the damage from the acetaminophen may be largely preventable. This is why anyone who overdoses on Tylenol receives large doses of NAC in the emergency room -- to increase glutathione.

2. B Vitamins

NAC is thought to work even better when combined with thiamine, or vitamin B1.6Vitamin B6 may also help to lessen hangover symptoms. Since alcohol depletes B vitamin in your body and they're required to help eliminate it from your body, a B-vitamin supplement taken beforehand, as well as the next day, may help.

3. Milk Thistle

Milk thistle contains silymarin and silybin, antioxidants that are known to help protect the liver from toxins, including the effects of alcohol. Not only has silymarin been found to increase glutathione, but it also may help to regenerate liver cells.7 A milk thistle supplement may be most useful when taken throughout the entire holiday season if you know you'll be having cocktails on more than one occasion.

4. Vitamin C

Alcohol may deplete your body of vitamin C, which is important for reducing alcohol-induced oxidative stress in your liver. Interestingly, one animal study showed that vitamin C was even more protective to the liver than silymarin (milk thistle) after exposure to alcohol.8 Just as with a dental anesthetic, vitamin C will also help detoxify alcohol, so make sure you're getting enough vitamin C, either via supplements or food, before indulging in alcoholic beverages.

5. Magnesium

Magnesium is another nutrient depleted by alcohol, and it's one that many are already deficient in. Plus, magnesium has anti-inflammatory properties that may help to reduce some hangover symptoms. If you don't eat a lot of magnesium-rich foods, taking a magnesium supplement before an evening involving drinking may be helpful.

Practical Tips to Avoid a Hangover

The pre-tox measures above are important for supplying your body with the vitamins, antioxidants, and other nutrients to protect your liver and assist in the breakdown and removal of alcohol from your system. Other practical measures that may help include:

Stay Hydrated: Drink a glass of water along with each alcoholic beverage to help prevent dehydration. At bedtime, drink another large glass of water or two to help stave off hangover symptoms in the morning.

Eat Beforehand and During: If your stomach is empty, it will speed the alcohol's rate of absorption into your body. It may also cause more severe stomach irritation. Make it a point to eat a meal before you drink alcohol and nibble on satisfying snacks (such as cheese) while you drink. At the very least, try this old piece of wisdom from the Mediterranean region -- take a spoonful of olive oil before drinking alcohol to help prevent a hangover.9

Replenish Electrolytes: Try drinking coconut water before you go to bed to help reduce hangover symptoms in the morning.

Stop Drinking When You're Buzzed: When you feel buzzed, it's a sign that your body's detoxification pathways are becoming overwhelmed. Take a break from drinking, or quit for the day entirely, to allow your body to metabolize the alcohol effectively.

You're Hung Over… Now What?

Ideally, the steps above will help you to avoid a hangover, but keep in mind that if you drink excessively, there is virtually no foolproof way to prevent all the ill effects. If you find yourself feeling hung over after too many drinks, don't try the "hair of the dog" remedy of drinking more alcohol – this will only prolong your reaction. Also avoid taking acetaminophen (Tylenol), which will only further tax your liver. Instead, try these hangover remedies to feel better faster:10

Exercise: If you can manage it, a short bout of high-intensity exercise may help you to sweat out some of the toxins. Be sure to drink plenty of water to avoid becoming even more dehydrated.

Replenish your body: Try bone broth for minerals, coconut water for electrolytes, eggs for natural cysteine, and coconut for potassium.

Ginger: If you're feeling nauseated, steep a piece of fresh ginger root in hot water for a natural stomach-settling tea.

Try a cup of black coffee: It may reduce swelling in your blood vessels, helping to relieve headache.

If You Drink Alcohol, Keep It in Moderation

If you're using the hangover pre-tox or remedies above, hopefully it is only for the very occasional use. While an infrequent drink here and there is not likely to cause too much damage, especially in combination with a healthful lifestyle, it's important to realize that alcohol is a neurotoxin that can poison your brain and disrupt your hormonal balance.

When it comes to alcohol, remember that using it in moderation is key and excessive use is virtually guaranteed to damage your health. I generally define "moderate" alcohol intake (which is allowed in the beginner phase of my nutrition plan) as a 5-ounce glass of wine, a 12-ounce beer, or 1 ounce of hard liquor with a meal, per day. As you progress further into reaching higher levels of health, I do recommend eliminating all forms of alcohol.

Disclaimer: The entire contents of this website are based upon the opinions of Dr. Mercola, unless otherwise noted. Individual articles are based upon the opinions of the respective author, who retains copyright as marked. The information on this website is not intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice. It is intended as a sharing of knowledge and information from the research and experience of Dr. Mercola and his community. Dr. Mercola encourages you to make your own health care decisions based upon your research and in partnership with a qualified health care professional. If you are pregnant, nursing, taking medication, or have a medical condition, consult your health care professional before using products based on this content.

If you want to use an article on your site please click here. This content may be copied in full, with copyright, contact, creation and information intact, without specific permission, when used only in a not-for-profit format. If any other use is desired, permission in writing from Dr. Mercola is required.

Disclaimer: The entire contents of this website are based upon the opinions of Dr. Mercola, unless otherwise noted. Individual articles are based upon the opinions of the respective author, who retains copyright as marked. The information on this website is not intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice. It is intended as a sharing of knowledge and information from the research and experience of Dr. Mercola and his community. Dr. Mercola encourages you to make your own health care decisions based upon your research and in partnership with a qualified health care professional. If you are pregnant, nursing, taking medication, or have a medical condition, consult your health care professional before using products based on this content.

If you want to use an article on your site please click here. This content may be copied in full, with copyright, contact, creation and information intact, without specific permission, when used only in a not-for-profit format. If any other use is desired, permission in writing from Dr. Mercola is required.