In 2005, Garris created and produced an original anthology television series of one-hour movies, written and directed by many of the "masters," which was originally broadcast in the U.S. on the Showtime cable network. In several international territories, the films were released theatrically.

The series debuted to excellent reviews in the U.S. on October 28, 2005 with the premiere episode "Incident On and Off a Mountain Road," co-written and directed by Don Coscarelli, based on the short story by Joe R. Lansdale. New episodes premiered every Friday at 10 p.m. EST throughout the series' two seasons. The show followed an anthology series format, with each episode featuring a one-hour film directed by a well-known horror filmdirector. In 2009, Chiller began airing the show on their Sunday evening line-up of shows, and in 2010, Reelz Channel began airing episodes of Masters of Horror edited (despite keeping its TV-MA rating) and with commercials.[1]

A recently divorced young man begins experiencing the world through the senses of a woman he's never met after eating a sample of chocolate. But his quest to meet her face-to-face leads to drastic consequences.

A 19th century American tourist gets much more than he bargained for while searching for a Japanese prostitute he fell in love with years earlier.

Episode 4, "Jenifer", was accidentally made available on-demand to a select audience at the same time as Episode 2, "H. P. Lovecraft's Dreams in the Witch-House". The episode was cut for graphic violence during its initial television broadcast, and the cut scenes can only be viewed in a featurette separate from the film on the R1 DVD release.

Episode 13, "Imprint", originally scheduled to premiere on January 27, 2006, was shelved by Showtime due to concerns over its content. Mick Garris, creator and executive producer of the series, characterized the episode as "the most disturbing film I've ever seen".[2] It is available only on DVD and Blu-ray by Anchor Bay Entertainment, along with the rest of the episodes in the first season.[3] "Imprint" was shown in the UK on Bravo (7 April 2006).[4]

The apocalyptic tale of a monstrous, unseen force that devastates Sheriff Kevin Reddle’s family and terrorizes their small Texas community. Based on the short story of the same title by Ambrose Bierce.

The story of Larry Pearce, an ordinary man blessed with gift/curse of extraordinary hearing that drives him to the brink of insanity, and forces him to take violent action to silence the horrific cacophony in his head.

Pro-Life tells the story of a young pregnant girl trapped inside an abortion clinic by her murderous family, who soon discovers the only thing more dangerous than her pursuers is the demonic secret that she carries within her.

Fur trader Jake Feldman knows that you cannot make a coat without breaking a few animals' necks. In his pursuit to make the perfect fur coat to win over a woman, Feldman steals supernatural raccoon pelts that violently turn against those that covet them.

A novelist rents a room in a flophouse to write a novel and discovers there are fates worse than literary anonymity when he encounters a mysterious woman and a stalking demon spawned from the imagination of three tenants.

After walking away from an auto accident that leaves his wife in a coma and on life support, a man must decide to let his wife die. But the situation becomes more nightmarish when her vengeful spirit threatens to expose a dirty secret of his own.

In 1841 Philadelphia, Edgar Allan Poe, suffering from writer's block and short on cash, is tormented by his wife's black cat that will either destroy his life or inspire him to write one of his most famous stories.

Jack, an American lawyer working in Tokyo, has fallen in love with the wife of his most valued client, Eiji. Despite Jack's deep-rooted fear of the sea, he reluctantly accepts Eiji's invitation to join the couple for a day trip on the Tokyo Bay. Pleasure slowly turns to terror as they discover the watery destiny in store for each of them.

A two-disc soundtrack was released for the series in October 2005 on Immortal Records. The album features heavy metal and rock acts with a few acoustic pieces. A second volume was released a year later.