The classical type of EDS includes EDS I (MIM 130000) and EDS II (MIM 130010). They are autosomal dominantly inherited disorders, and considered the most common types of EDS. It is caused by mutations in COL5A1 and COL5A2 genes. Findings in patients with EDS I (gravis type) include marked skin involvement (hyperextensibility, atrophic scars) generalized joint hypermobility and complications there of (dislocations, subluxations, pes planus), muscular hypotonia, and delayed motor development. Additional findings may include rupture of the aorta or bowel. Prematurity is also common. Findings in EDS II (mitis type) are similar to, but less severe than, EDS I. The skin is less involved and joint laxity may be confined to hands and feet. Prematurity is not a feature.