Neurontin (Gabapentin) is an antiepileptic and nerve pain reliever. Researchers don't know exactly how it works, but it has a similar structure to GABA, a neurotransmitter that calms nerves in the brain and spinal cord.

Oleptro (Trazodone) is a serotonin reuptake inhibitor (SRI) antidepressant. It increases serotonin activity in the brain, which regulates mood.

The free Iodine Start program helps people track how well they are improving, and find the right antidepressant faster.

The free Iodine Start program (personal reports and coaching) is currently only for antidepressants. For now, you can read our pharmacist info about this medication.Learn more about Neurontin (Gabapentin) ›

The free Iodine Start program (personal reports and coaching) is currently only for antidepressants. For now, you can read our pharmacist info about this medication.Learn more about Oleptro (Trazodone) ›

› You can't skip or miss doses since suddenly stopping Neurontin (Gabapentin) can cause seizures. This is even more likely if you drink alcohol, so it might not be the best medication for heavy drinkers.

› It's available as a generic, so it's less expensive than similar medications.

› Commonly used in lower doses to help treat sleep problems (insomnia).

› Safer sleep medication than others (benzodiazepines or Unisom) for people age 65 and older.

› Fewer sexual side effects than many other antidepressants.

› Has been used for sleep and depression for a long time. There's a lot of information available about how it works and how safe it is.

› Comes as a generic medication and is cheaper than many other sleep aides.

› Six out of ten people who use an antidepressant for the first time find that it works for them.

Downsides and risks

Neurontin

Oleptro

› Neurontin (Gabapentin) is likely to cause some side effects, including memory problems, drowsiness, dizziness, or confusion.

› You can't skip or miss doses since suddenly stopping Neurontin (Gabapentin) can cause seizures. This is even more likely if you drink alcohol, so it might not be the best medication for heavy drinkers.

› Not as effective as other medications for depression.

› More sedating than other antidepressants.

› Causes more side effects when used at higher doses for depression. Includes sleepiness, dizziness, upset stomach, and irregular heartbeat.

› Like most antidepressants, can cause higher risk of suicidal thoughts and behavior for people age 24 and younger.

› The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.

Tips from our pharmacists for people taking the medication

Neurontin

Oleptro

› Side effects are common, but usually manageable.

› Don't drive while taking Neurontin (Gabapentin) until you know how the medication affects you.

› Neurontin and generic forms of Gabapentin have the same ingredients as Gralise and Horizant, but are dosed differently. Make sure you know which form you're taking since they are used for different purposes.