The purpose of this Notice is to alert the scientific
community that the NIH Common Fund Protein Capture Reagents program is seeking
input on the program's priority list for production of human transcription
factor (hTF) affinity reagents. Please go to http://commonfund.nih.gov/proteincapture/reagents/index.aspx for more information and to submit comments.

Briefly, the lack of access to affordable,
well-characterized and analytically validated renewable protein capture
reagents has been expressed at large by scientific community. In response to
this concern, the Protein Capture Reagents program was launched to pilot
whether a community resource of high quality, renewable affinity reagents can
be economically generated for all human proteins, and to develop technologies
that will lead to next generation platforms for producing renewable protein
capture reagents. This pilot effort includes the generation of affinity
reagents (monoclonals and recombinant Fabs) against all hTFs as a test case.

A priority list of targets for production of human
transcription factor affinity reagents has been generated. We seek public
comment on this priority list, and encourage the community to become involved
by aiding in the further validation of these reagents. We are also open to
requests for additional TFs to be added to the priority list with
justification.

The priority list will be updated on a quarterly basis.
Sign-up is available on the website to receive notifications when updated lists
are posted. Information on completed reagents will be posted on the Protein
Capture web portal (in development), and reagents will be made available
through the University of Iowa's Developmental
Studies Hybridoma Bank.