May cause irritation of the digestive tract. May be harmful if
swallowed.

INHALATION

Causes respiratory tract irritation. May be harmful if inhaled.

CHRONIC

TRANSPORT
& REGULATORY INFORMATION

UN
NO.

2810

HAZARD CLASS

6.1

PACKING GROUP

III

HAZARD SYMBOL

T
XN

RISK PHRASES

5-25-36/37/38

SAFETY PHRASES

53-36/37-45

OTHER
INFORMATION

The Mitsunobu Reaction allows the conversion of primary and secondary
alcohols to esters, phenyl ethers, thioethers and various other compounds. The
nucleophile employed should be acidic, since one of the reagents (DEAD,
diethylazodicarboxylate) must be protonated during the course of the reaction to
prevent from side reactions. (source:http://www.organic-chemistry.org/namedreactions/mitsunobu-reaction.shtm)

The Mitsunobu reaction is a unique dehydration-condensation reaction between
alcohols and various nucleophiles using the redox system comprised of diethyl
azodicarboxylate (DEAD) and triphenylphosphine (TPP).The reactions
proceed under mild conditions, and a wide variety of compounds can be used as
nucleophiles, for example, carboxylic acids, active methylenes, imides, thiols,
etc. The reaction between secondary alcohols and nucleophiles yields products
with Walden inversion. The Mitsunobu reaction has been used widely in organic
synthesis. Due to its utility, efforts have been made to expand application of
the Mitsunobu reaction, and modified reactions have been reported. For example, by using azodicarboxamides instead of azodicarboxylates the
Mitsunobu reaction is being applied to weak-acidity nucleophiles with a higher
pKa value. Methods have also been reported for the easy
removal of phosphine oxide, a reaction by-product, by utilizing phosphines which
have an intramolecular basic component and diphenylphosphino
polystyrene resin. (source: http://www.tci-asiapacific.com/product/synthetic-chem/S004.shtml)

The
Mitsunobu reaction has proven to be a useful, diverse
and practical method for C-O, C-N, C-C and C-X bond
formation, among other uses. Its mild reaction conditions
and excellent stereoselectivity make it an excellent
reaction that serves its purpose well. It will no doubt
continue to be an important synthetic tool for the practicing
organic chemist.(source:http://www.chem.wisc.edu/areas/organic/studsemin/jantzi/jantzi-abs.pdf)