Susan PrescottSchool of Pediatrics and Child Health, University of Western Australia, Perth, Western AustraliaExpert Rev Vaccines 3:339-42. 2004

..It describes how the development of future vaccine strategies relies on a detailed understanding of immune ontogeny and the potential consequences of intervention on developing cellular immune responses...

..This review examines new developments in the area of foetal and early postnatal immune maturation. It secondly addresses early predisposing influences and protective factors that may have a future role in allergy prevention...

..This review examines the evidence for a potential role of changing dietary intake of omega-3 polyunsaturated fatty acids in the development, treatment and prevention of allergic diseases...

New concepts of cytokines in asthma: is the Th2/Th1 paradigm out the window?

S L PrescottSchool of Paediatrics and Child Health, University of Western Australia, Perth, Western AustraliaJ Paediatr Child Health 39:575-9. 2003

..It also highlights emerging concepts that the excessive and inappropriate immune responses seen in allergic disease may be related to dysfunction of various interleukin-10 producing regulatory cell populations...

..Implementation of obstetric and neonatal interventions has reduced mother to child transmission of HIV. Health outcomes for Aboriginal people are often worse than for non-Aboriginal people; was this the case for HIV infection in pregnancy?..

..It will also examine the growing case for introducing complementary foods from around 4 months of age and maintaining breastfeeding during this early feeding period, for at least 6 months if possible...

Effects of early cigarette smoke exposure on early immune development and respiratory disease

Antimicrobial and anti-inflammatory activity of five Taxandria fragrans oils in vitro

Katherine A HammerDiscipline of Microbiology and Immunology, School of Biomedical, Biomolecular and Chemical Sciences, The University of Western Australia, Crawley, WA, AustraliaMicrobiol Immunol 52:522-30. 2008

..In conclusion, T. fragrans oil showed both antimicrobial and anti-inflammatory activity in vitro, however, the clinical relevance of this remains to be determined...

..The specific mechanisms regulating priming of T-cell immunity to common allergens during early childhood remain to be elucidated, though increasing evidence indicates that antigen-presenting cell function is impaired in childhood...

..All these observations underscore the need for ongoing research to understand the pathogenesis and rising incidence of disease in the hope of better strategies to reverse this...

Silent mysteries: epigenetic paradigms could hold the key to conquering the epidemic of allergy and immune disease

D J MartinoSchool of Pediatrics and Child Health Research, University of Western Australia, Perth, Western Australia, AustraliaAllergy 65:7-15. 2010

..Identifying genes that are differentially silenced or activated in relation to subsequent disease will not only assist in identifying causal pathways, but may also help identify the contributing environmental factors...

Role of dietary immunomodulatory factors in the development of immune tolerance

Probiotic supplementation for the first 6 months of life fails to reduce the risk of atopic dermatitis and increases the risk of allergen sensitization in high-risk children: a randomized controlled trial

..The role of regulatory T (Treg) cells in allergic predisposition is not known...

Postnatal development of monocyte cytokine responses to bacterial lipopolysaccharide

Stephanie T YerkovichFaculty of Medicine and Dentistry, Telethon Institute for Child Health Research, The University of Western Australia, Perth WA 6872, Western AustraliaPediatr Res 62:547-52. 2007

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The effects of fish oil supplementation in pregnancy on breast milk fatty acid composition over the course of lactation: a randomized controlled trial

Janet A DunstanSchool of Paediatrics and Child Health, The University of Western Australia, Crawley WA 6009Pediatr Res 62:689-94. 2007

..Thus, supplementation in pregnancy was associated with increased n-3 long-chain polyunsaturated fatty acids (LCPUFAs) in breast milk, particularly in early lactation, and this was positively associated with infant DHA status at 1 y...

Fish oil supplementation in pregnancy modifies neonatal progenitors at birth in infants at risk of atopy

..Amino acid formula is recommended as first choice in anaphylaxis and eosinophilic oesophagitis. If treatment with the initial formula is not successful, use of an alternative formula is recommended...