For the moment, Marvel’s The Inhumans plan remains to debut the first two (of eight) episodes in IMAX theaters in September 2017, before moving the series to its new ABC home. Reports have specified that The Inhumans will not be an Agents of S.H.I.E.L.D. spinoff (meaning strictly that S.H.I.E.L.D. won’t introduce the characters), though IGN also confirmed with Marvel that The Inhumans is not immediately intended as a replacement for Coulson’s crew:

Additionally, we’ve been told that Inhumans has no impact on the fate of Agents of SHIELD. No decision has been made as to whether Agents of SHIELD will return for a fifth season or not.