I got some nasty Virtumonde and Vundo infections yesterday.
After 10 hours of poking around I finally fixed it. An IT guy I know wasn't able to fix his last year and had to reformat, that's how tough it is.

I myself use Norton Protection Center, worked fine so far. Even on the Porn sites I visit lol.
Intrusion prevention seems to be effective.
Some years ago I went with only freeware but this time I decided to pay for protection for my laptop, hopefully things will keep functioning.
Better to be informed though so advice like yours are appreciated.

I had the Vundo problem just before Christmas, nasty little thing, had my brother in law fix it for me remotely, although my system is stable again I still have a few problems (like task manager disabled etc) so might just give this a shot to see if it makes a difference