Potential conflict of interest: Alessio Aghemo is on an advisory committee for Roche. Maria Grazia Rumi is on advisory committees for Tibotec, Roche, and Janssen Cilag. Massimo Colombo has received grant and research support from Merck, Roche, BMS, and Gilead Science; is on advisory committees for Merck, Roche, Novartis, Bayer, BMS, Gilead Science, Tibotec, Vertex, and Achillion; and has received speaking and teaching engagements from Tibotec, Roche, Novartis, Bayer, BMS, Gilead Science, and Vertex.

Supporting Information Figure 1: A-D: lymphocyte immunophenotyping on liver biopsies from the same patient obtained after the achievement of an SVR. (A) B-cells are mainly confined within the lymphoid follicle (CD20 immunostaining, original magnification 200X). (B) CD8+ T-cells are expressed within the lymphoid follicle and the portal tract (CD8 immunostaining, original magnification 200X). (C) CD4+ T-cells are present only in the portal tract, whereas no cells are labeled at the interface (CD4 immunostaining, original magnification 200X). (D) TReg FoxP3+ cells are rare in the portal tract (arrows; FoxPs immunostaining, original magnification 200X).

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