The invasion of leucocytes into cerebrospinal fluid (CSF) has grave prognostic significance in leukaemic patients. Flow cytometric analysis provides a highly specific diagnostic tool, however cells within CSF are typically low in concentration and degrade quickly. This results in the necessity to stabilise CSF specimens to achieve accurate analysis.

TransFix® is a stabilisation solution which has been shown to stabilise the cellular component of cerebrospinal fluid. TransFix has therefore been has been recommended for use in guidelines published in the British Journal of Haematology (case study 1) among others.