Overview

Systematic Review Conclusion

Critical Summary Assessment

Based on the limited evidence from the meta-analysis of 2 short-term randomized controlled trials, rhPDGF-BB led to statistically significant short-term clinical difference in attachment gain and percentage of bone fill, with rhPDGF-BB in combination with beta-tricalcium phosphate (ß-TCP) in periodontal defects, compared with defects treated with ß-TCP alone. However, considering the minimal absolute improvement and the significant added cost to the patient, the routine use of rhPDGF-BB over conventional techniques may not be justified.