Phenotypic differences in growth, matrix synthesis and response to nifedipine between fibroblasts derived from clinically healthy and overgrown gingival tissue.

@article{McKevitt1995PhenotypicDI,
title={Phenotypic differences in growth, matrix synthesis and response to nifedipine between fibroblasts derived from clinically healthy and overgrown gingival tissue.},
author={K M McKevitt and Christopher Robert Irwin},
journal={Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology},
year={1995},
volume={24 2},
pages={66-71}
}

Gingival overgrowth is a disfiguring condition affecting 10-20% of patients on nifedipine therapy. The pathogenesis of this condition, although unclear, is thought to involve an interaction between the drug and resident gingival fibroblasts. The aim of the present study was to investigate the cellular mechanisms underlying this condition using cell culture techniques. Gingival fibroblast cell lines were derived by explant culture from two patients on long-term nifedipine therapy exhibiting… CONTINUE READING