BioTek offers many peripheral instruments and accessories to expand functionality and enhance assay workflows. Many peripheral instruments and modules are compatible with several different instruments, see the list here.

BioTek's highly trained sales and service professionals are experts in life science instrumentation. They will guide you through your decision process and help you select the proper equipment for your application, assist with installation in your lab, and train your staff on the use of the instrumentation.

November 14, 2018 - BioTek Instruments extends congratulations to Dr. Benjamin R. King as this year’s recipient of the Norman R. Alpert Research Prize. The honor, which includes an engraved plaque and cash award, was announced at the Larner College of Medicine Research Day event held at The University of Vermont (UVM) on October 30, 2018. Weiterlesen

October 22, 2018 - BioTek is pleased to congratulate its President and CEO, Briar Alpert, for receiving the 2018 Alumni Achievement Award from the University of Vermont (UVM) Alumni Association. The award recognizes alumni demonstrating outstanding commitment to Vermont, the University, and the local community. Weiterlesen

October 16, 2018 - BioTek has released a Peltier Cooling Module for the Cytation™ Cell Imaging Multi-Mode Readers. The compact module keeps internal temperature rise to less than one degree over ambient, regardless of fluctuations from external and internal factors. The module helps maintain and optimize stability for more consistent data in assays run at ambient temperature. The module also quickly reduces internal temperature after incubated assays for efficient transitions between multiple applications with different temperature requirements. Weiterlesen

March 2 - 6, 2019

Booth #404

Baltimore Convention Center

Nothing can speak to the experience you'll encounter with BioTek like stories from our customers themselves. Customer satisfaction is our top priority. From Engineering to Manufacturing to Sales and Support, BioTek employees around the world are dedicated to providing the best product and best customer experience in the industry.

At BioTek we feel passionately and genuinely that our employees are our greatest asset. We continue to build our already impressive team having doubled our global workforce in the last five years. With our headquarters in the beautiful Green Mountains of Vermont, USA, we also have regional offices around the world.

If you're interested in becoming part of our amazing team, check out our list of job openings today!

As a prospective partner, BioTek can help you achieve your sales and market penetration by providing a unique blend of products, service, support, training, co-marketing and quality assurance designed to meet your customers’ requirements while you remain focused on your core business.

At BioTek we feel passionately and genuinely that our employees are our greatest asset. We continue to build our already impressive team having doubled our global workforce in the last five years. With our headquarters in the beautiful Green Mountains of Vermont, USA, we also have regional offices around the world.

If you're interested in becoming part of our amazing team, check out our list of job openings today!

Introduction

Cell migration involves a cyclical coordinated procedure starting with cell polarization, protrusion and substrate attachment of the leading edge, in addition to proteolytic degradation of physical barriers (e.g. tissue components and actinomyosin contraction) before the cell moves. Migration plays a central role in multiple beneficial physiological processes such as wound healing, in addition to being the first step in tumor metastasis as cells move away from the primary tumor site. Therefore, an advanced knowledge and methodology for monitoring phenotypic cell migration is useful for screening potential negative cytotoxic effects in test molecules, as well as speeding the development of novel therapies to re-establish wound healing abilities in pathologic tissue or control metastatic cellular invasion. Multiple techniques currently exist to assess cell migration. These commonly involve monitoring the migration of cells adhered to labware. The easiest and most sensitive of these methods incorporate label-free imaging to precisely track cell movement without introducing fluorescent probes that have the capability of changing normal cell activity. However, there are limitations to these migration assays. First, these assays use monolayers, which poorly mimic native tissue environments. In particular, these monolayers do not simulate tissue structure and properties, have altered cell exposure to compounds, and lack normal cell-cell and cell-extracellular matrix (ECM) interactions that characterize living tissue. Thus, cell migration witnessed in monolayers may misrepresent behavior seen in vivo.

Three-dimensional (3D) cell culture platforms are potential solutions as they can reconstruct tissue structure and environments in vitro. In particular, incorporation of magnetic 3D bioprinting, where cells are magnetized and printed into appropriate 3D cell cultures, provides a method to reestablish missing interactions and easily create 3D phenotypic cell migration assays. Using this method, cells are magnetized with a biocompatible nanoparticle assembly consisting of gold, iron oxide, and poly-L-lysine that electrostatically and non-specifically attaches to cell membranes. Magnetized cells can then be directed using mild magnetic forces to form aggregates where cells interact and build larger 3D environments with ECM that represent native tissues. Cells and matrix can then be printed into different configurations to assess wound healing and metastatic cell movement. Here we present two bioprinting procedures that were created to allow 3D wound healing and metastatic cell movement to take place in vitro. Label-free cell migration was tracked over time using automated widefield microscopy. Final combined processes were tested using multiple skin and cancer cell models in 384-well format to demonstrate that the incorporation of 3D magnetic bioprinting can lead to the generation of in vivo-like cell migration data.