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Spina Bifida: Trials Ahead

Author

Wynn, Jane

Bibliographic Citation

Nature. 1982 Sep 16-22; 299(5880): 198.

Abstract

Controversy has erupted in Britain over the ethical implications of
an impending clinical trial to investigate the role of folic acid and other
multivitamin supplements in the prevention of neural tube defects. The study
population will consist of women who had previously conceived a spina bifida
child and who are now planning another pregnancy. Some critics, believing
there is already sufficient evidence of a folic acid link to spina bifida,
object to withholding folic acid from one of the high-risk control groups.
Concern has also been expressed about the extent to which participants will be
briefed. (KIE abstract)