製品の概要

Full length native protein (purified from a homogenate of a mammary tumour specimen) (Human).

ポジティブ･コントロール

Human tonsil tissue

特記事項

Tenascin is a high molecular weight, multifunctional, hexameric extracellular matrix glycoprotein expressed in association with mesenchymal epithelial interactions during development and in the neovasculature and stroma of undifferentiated tumors. It has been described under a variety of names: cytotactin, hexabrachion protein, J1, myotendinous antigen (MI) and glioma mesenchymal extracellular matrix (GMEM). The tenascin molecule is a disulfide-linked hexamer. The expression of tenascin is associated with development and growth, both normal and pathological, whereas the distribution in normal adult tissue is restricted.

製品の特性

製品の状態

Liquid

保存方法

Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

Tenascin is a high molecular weight, multifunctional, hexameric extracellular matrix glycoprotein expressed in association with mesenchymal epithelial interactions during development and in the neovasculature and stroma of undifferentiated tumors. It has been described under a variety of names: cytotactin, hexabrachion protein, J1, myotendinous antigen (MI) and glioma mesenchymal extracellular matrix (GMEM). The tenascin molecule is a disulfide-linked hexamer. The expression of tenascin is associated with development and growth, both normal and pathological, whereas the distribution in normal adult tissue is restricted.

Use at an assay dependent concentration. Detects a band of approximately 240 kDa.

ICC/IF

Use at an assay dependent concentration. PubMed: 20435685

ターゲット情報

機能

Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6.

Thank you for your patience.
I have contacted the originators of ab3970, ab6393, and ab7839 and have received the following replies:
ab3970 - This antibody reacts with tenascin; it was raised against mammary tumor of human origin. Tenascin-C cou...

Thank you for your recent phone call and your interest in our tenascin and myosin heavy chain antibodies.
As we discussed we do not currently have antibodies which have been tested in chicken tissue and the homology searches revealed that for tenas...

Thank you for the details of your protocol, my apologies for the delay due to a long bank holiday weekend in the UK. This antibody has been tested in IHC on formalin-fixed paraffin embedded tissue, I would therefore suggest using formalin fixation as i...