The tactics of dealing with myelodysplastic syndrome (MDS) is developed individually, focusing on the patient's condition. Chemotherapy and immune therapy is usually recommended for patients from the group of medium and high risk. In some cases, such treatment is preceded by bone marrow transplantation.

Diagnostic Measures

On the eve of treatment, the patient consults an oncologist. The physician clarifies complaints, conducts clinical examination and prescribes the required tests:

complete blood count,

blood chemistry,

cytogenetic analysis.

Based on the test findings, the optimal dosage regimen is selected.

Procedure

The patient is hospitalized for a period of 16 days. Hypomethylating drugs increasing the duration and improving the quality of the patient’s life are used for treatment.

The studies of MDS pathogenesis showed that the leading role in the disease development is played by changes in the stem cell DNA. This process leads to the appearance of myeloblasts in bone marrow and impaired hematopoiesis. Hypomethylating agents (azacitidine, decitabine) restore the normal structure of DNA, inhibiting the further formation of tumor cells.

The drugs are administered intravenously. As regards side effects, the patients may report:

nausea,

increased body temperature,

reduction of platelet count, red blood cells and neutrophils.

Symptomatic therapy is prescribed to correct this condition.

Patients at high risk can be indicated low doses of cytarabine, a cytostatic. Therapy is also conducted intravenously under medical supervision by the hematologist. The cost of drugs depends on the treatment intensity.

During treatment, the patients receives meticulous care. After cycle completion, the patient is provided recommendations for further action.

The Department I for Internal Medicine of the University Hospital Cologne deals with the treatment of patients with various internal diseases. This includes in particular the following fields: Oncology, Hematology, Clinical infectology, Clinical immunology, Hemostasis, Intensive care.

University Hospital Frankfurt

Department of Hematology, Oncology, Rheumatology and Immunology

The Department of Hematology, Oncology, Hemostasis, Rheumatology and Infectology at the University Hospital Frankfurt specializes in the treatment of all diseases of the hymatopoietic system and solid tumors.

Charite University Hospital Berlin

Charité Comprehensive Cancer Center

The Charité Comprehensive Cancer Center integrates the clinical and research activities for all Charité departments and institutes dealing with Cancer. The director of the Charité Comprehensive Cancer Center is Prof. Dr. med. Ulrich Keilholz.

University Hospital Heidelberg

Department of Hematology, Oncology and Rheumatology

The Department of Hematology, Oncology and Rheumatology at the Heidelberg University Hospital makes every effort to provide medical care of the highest quality to the patients with oncologic and rheumatologic diseases.

Academic Hospital Schwabing

The Department of Hematology, Oncology, Immunology, Palliative Medicine, Infectious Diseases and Tropical Medicine in Schwabing treats all benign blood diseases, disorders of the immune and coagulation system, all forms of blood cancer, and the most of cancers.

Academic Hospital Nordwest

Department of Oncology and Hematology

The Department of Oncology and Hematology at the Hospital Nordwest is a medical institution, which deals with the diagnosis, treatment and follow-up care of patients with benign and malignant tumors of the hematopoietic system, as well as all kinds of cancer.

University Hospital RWTH Aachen

Department of Oncology, Hematology and Stem Cell Transplant

The Department of Oncology, Hematology and Stem Cell Transplant provides patient care on both inpatient and outpatient basis. The focuses of the inpatient treatment are acute leukemia and high-dose chemotherapy followed by autologous blood stem cell transplantation.

University Hospital Düsseldorf

Department of Hematology, Oncology and Clinical Immunology

The Department of Hematology, Oncology and Clinical Immunology at the University Hospital Dusseldorf provides treatment of patients with blood diseases, cancer and immune system diseases. The Department focuses on the treatment of malignant diseases of blood, bone marrow and lymph nodes.

Hannover Medical School

The clinic of hematology, hemostasis, oncology and stem cell transplantation is a leading therapeutic clinic of the Medical Institute of Hannover for patients with solid tumor and systemic diseases, with other partially benign diseases of the hematopoietic system, as well as bleeding disorders.

District Hospital Waldbröl Oberberg

The Department of Hematology, Oncology, Palliative Medicine, Pneumology and Somnology at the District Hospital of Waldbröl (Medical Department III) has 30 beds. A competent treatment is provided by three medical specialists in the field of hematology and oncology and a professional anesthesiologist.

University Hospital Halle (Saale)

Department of Hematology and Oncology (Department of Internal Medicine IV)

The Department of Internal Medicine IV (Hematology and Oncology) covers the whole range of hematology and oncology. This includes prevention, diagnosis, therapy and post-operative care for cancer of all organs and blood.