30-year-old Meredith is described as white, of large build and with very long ginger hair.

She was last seen wearing a black coat, black tight jeans and black top with floral pattern sleeves and bright pink trainers.

Both John and Meredith have mental health issues and could present as paranoid or aggressive.

Detective Chief Inspector Claire Mcenery said: ‘It’s been a few days since John and Meredith went missing and I would appeal for anyone who sees them or knows where they might be to get in touch with us.

‘I would also appeal directly to John and Meredith and assure them that they won’t be separated when they are found as I know this is causing them some concern. I’d also remind John that Meredith needs to take her medication so could he contact police or their place of residence in Bury to allow this to happen.’

Anyone with information should contact police on 101 quoting log number 0450 of November 3rd.