Barcelona play ahead of the reigning champions and have to tricky trip to take on Getafe, who defeated them last season and have already won at home to Real Madrid this campaign.

Barca coach Tito Vilanova will again watch the game from the stands as he sits of the second game of a two-match ban, while Andres Iniesta is out through injury after suffering a groin injury while on international duty with Spain.

Meanwhile Alvaro Vazquez, who last season scored against Barca for Espanyol will lead the Getafe attack after joining the club during the summer.

Real Madrid also have a complicated away match as they take on Sevilla in the Sanchez Pizjuan Stadium. Sevilla have suffered heavy home defeats to Madrid in the past two years, but should still present a tough challenge with an attack led by Alvaro Negredo and Jesus Navas.

Meanwhile all eyes will be on Cristiano Ronaldo, who makes his first appearance for Madrid after his announcement he was 'sad' a fortnight ago. The Madrid striker is likely to receive little sympathy from the home fans in a city where unemployment is a major problem.

Spain's other two sides in Champions League action are also playing on Saturday: Malaga, who have had a positive start to the campaign despite financial worries, entertain Levante, who are finding life tougher this season.

Valencia are in action against Celta Vigo, but coach Mauricio Pellegrino has injury problems in midfield. David Albelda is out with a muscle injury, which Fernando Gago will also miss the game after suffering a neck injury while on duty with Argentina in midweek.

Sunday kicks off with Espanyol looking for their first points of the season at home to Athletic Club Bilbao. The waters appear to have calmed in Bilbao after the departure of Javi Martinez to Bayern Munich and striker Fernando Llorente could return to action after suffering muscle problems at the start of the campaign.

Granada look for their first win at home to recently promoted Deportivo la Coruna, who are unbeaten on their return to the top flight, while Osasuna, who like Espanyol are so far without points, have a tough game at home to a Mallorca side currently second in the table with two wins and a draw from their opening three matches.

Real Sociedad coach, Philippe Montanier needs a win at home to Zaragoza to end criticism of his work at the club, while Atletico Madrid will look to capitalize on their confident start to the season with a home match against Madrid based Rayo Vallecano.

Radomal Falcao will be the main threat as Atletico look for their second home win of the campaign.

Finally the round of matches ends on Monday when Valladolid take on Betis.