Drug Interaction: Avoid excessive alcohol consumption. Anticholinergic effects of chlorphenamine (e.g. dry mouth, blurred vision) may be enhanced by drugs with anticholinergic effects such as antipsychotics, MAOI or tricyclic antidepressants. Chlorphenamine inhibits phenytoin metabolism and can lead to phenytoin toxicity.

Mechanism of Action: Chlorphenamine is an H1-receptor antagonist which competetively blocks H1-receptor sites on tissues.

Pregnancy Impact: Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.

Impact During Lactation: There are no controlled studies in breastfeeding women, however the risk of untoward effects to a breastfed infant is possible; or, controlled studies show only minimal non-threatening adverse effects. Drugs should be given only if the potential benefit justifies the potential risk to the infant.

Drug Interaction: Dextromethorphan is known to interact with other drugs like abiraterone acetate, amiodarone (HCl), fluoxetine (HCl), haloperidol, mitomycin C, moclobemide, paroxetine, phenelzine, propafenone (HCl), quinidine, sibutramine. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Mechanism of Action: Dextromethorphan is an opioid-like drug that binds to and acts as antagonist to the NMDA glutamatergic receptor, it is an agonist to the opioid sigma 1 and sigma 2 receptors, it is also an alpha3/beta4 nicotinic receptor antagonist and targets the serotonin reuptake pump. Dextromethorphan is rapidly absorbed from the gastrointestinal tract, where it enters the bloodstream and crosses the blood-brain barrier.

Pregnancy Impact: Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

Impact During Lactation: There are no controlled studies in breastfeeding women, however the risk of untoward effects to a breastfed infant is possible; or, controlled studies show only minimal non-threatening adverse effects. Drugs should be given only if the potential benefit justifies the potential risk to the infant.

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In compliance with Drug and Cosmetic Act and Rules, we don't process requests for Schedule X and other habit forming drugs. For Schedule H and H1 drugs a valid prescription from a registered medical practitioner needs to be uploaded with Order.