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US-led coalition air and artillery strikes have killed 70 Isil fighters in Fallujah, including the jihadists' leader in the Iraqi city, a military spokesman said on Friday.

Baghdad-based Colonel Steve Warren said that over the last four days, 20 strikes in the besieged city had destroyed Islamic State of Iraq and the Levant (Isil) fighting positions and gun emplacements.

"We've killed more than 70 enemy fighters, including Maher Al-Bilawi, who is the commander of Isil forces in Fallujah," Col Warren said.

"This, of course, won't completely cause the enemy to stop fighting, but it's a blow. And it creates confusion and it causes the second-in-command to have to move up. It causes other leadership to have to move around," he added.

"Those leaflets directed those who cannot leave to put white sheets on their roofs to mark their locations. The Iraqi Army is working hard to establish evacuation routes. And the local Anbar government has set up camps for displaced civilians."