Pilot Study of the Utility of New Surrogate Microbial Markers to Assess in vivo Antimicrobial Activity in HIV-infected and HIV-uninfected Adults with Pulmonary Tuberculosis Receiving Standard Drug Therapy

5 adults with suppurative respiratory diseases other than tuberculosis

Study Period

1995-2001

Goal of Study:

The pilot surrogate microbial marker studies of the TB Research Unit has two goals: first, to evaluate the performance characteristics of new microbiologic and molecular biologic techniques and assays in a group of HIV-non-infected and HIV-infected adults with sputum smear positive tuberculosis and then, secondly, to validate the utility of promising techniques in prospective studies and clinical trials. The study is an ongoing study at multiple sites to facilitate the rapid evaluation of new methods of assessing microbial response to therapy in human TB.

Objectives of Study:

To allow assessment of the ability of the microbial test under study to detect rapid early changes bacillary load during the early part of treatment