Light emitting diodes (LEDs) are widely used in lighting applications. In this study, we examined the differences in the degree of the color change of various medicines between LED lighting and fluorescent lighting. The degree of the color change of the medicines was evaluated subjectively, by the observation of the evaluator, as well as objectively, using a colorimeter. Noticeable color changes were observed in the Lasix® 20-mg Tablet(Tab), Fluitran® 2-mg Tab, and Phenobal® powder after exposure to either LED lighting or fluorescent lighting. Interestingly, the color change of the Lasix® 20-mg Tab was smaller for the LED lighting than for the fluorescent lighting.