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Specific antibodies have been developed which increase our understanding of the topographical arrangement of a major intramembranous subunit

Antibodies have been developed which show high specificity towards the specific proteins expressed in osteoblasts and a range of cancer cells. One of these antibodies can inhibit bone resorption due to osteoclasts and the migration of metastatic cancer cells in culture. Patents covering these discoveries are in the process of submission. The results have clear potential for immunotherapeutic approaches to osteoporosis and cancer.