Chronic electrode implants are key for the treatment of different conditions like Parkinson disease, tremor, and dystonia and to alleviate symptoms of otherwise treatment-resistant disorders, such as chronic pain. Currently, probes made of silicon micro needles or metal wires are widely used, but its large mechanical and geometrical mismatch is limiting its chronic utility. Furthermore, implant size limitations restrict the electrochemical properties of gold electrodes that are necessary for enhanced selectivity of single unit activity. The use Graphene coated with Titanium Nitride (TiN) as electrodes interface will result in lower impedance and higher injection capacity due to its higher electrochemical surface area (ESA). Moreover the flake-like morphology of graphene provides a major flexibility combined with the well-known electrochemical performance of TiN. The fabrication of devices with above mentioned materials and the use of a physiologically responsive, softening substrate are presented in this work