On www.antibodies-online.com are 106 Calcium Channel, Voltage-Dependent, gamma Subunit 2 (CACNG2) Antibodies from 14 different suppliers available. Additionally we are shipping and many more products for this protein. A total of 112 Calcium Channel, Voltage-Dependent, gamma Subunit 2 products are currently listed.

Study shows the expression of the TARP (show TARP Antibodies) gamma2 in a non-mammalian vertebrate, and reveals a functional role for Cacng2a in synaptic physiology and development; suggests that Cacng2a is required for normal trafficking and function of synaptic AMPARs, while Cacng2b is largely non-functional with respect to the development of AMPA (show GRIA3 Antibodies) synaptic transmission

we show that the TARP gamma-2 (stargazin) is present in spinal dorasl horn neurons and is necessary in a form of inflammatory pain-induced plasticity

the density of AMPARs correlates with that of TARP gamma-2 across SCC (show CYP11A1 Antibodies) synapses and its high expression is linked to high-density AMPAR expression at perforated type of pyramidal cell synapses

in the absence of stargazin, the refinement of the retinogeniculate synapse is specifically disrupted during the experience-dependent phase. Stargazin expression and phosphorylation increased with visual deprivation.

A transient positive feedback mechanism between AMPAR and stargazin has implications for information processing in the brain, because it should allow activity-dependent facilitation of excitatory synaptic transmission through a postsynaptic mechanism.

The additional cleft closure and/or stabilization of the more closed-cleft states of the LBD is expected to translate to higher agonist efficacy and could contribute to the structural mechanism for stargazin modulation of AMPAR function.

Autoinactivation is a subunit and splice form dependent property of AMPA (show GRIA3 Antibodies) receptor-stargazin complexes, which involves structural rearrangements within the complex rather than any physical dissociation.

Susceptibility to chronic pain following nerve injury is genetically affected by CACNG2

the Q/R site modulates the interaction of stargazin with the transmembrane domains of AMPA (show GRIA3 Antibodies) receptors via an allosteric mechanism and that this modulation leads to the observed differences in the electrophysiological properties of the receptor

Antigen Summary

The protein encoded by this gene is a type I transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family. This gene is a susceptibility locus for schizophrenia.