Baby aspirin deactivates COX-1 irreverisbly (on platelets) prior to entry in the liver. Systemic COX-2 deactivation via salicylate is next to nil at 81mg. Timing doesn't matter. It will enhance, not hinder, your ArA run by reducing TxA2 formation as a metabolite of ArA

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The above is my own opinion and does not reflect the opinion of PES

Baby aspirin deactivates COX-1 irreverisbly (on platelets) prior to entry in the liver. Systemic COX-2 deactivation via salicylate is next to nil at 81mg. Timing doesn't matter. It will enhance, not hinder, your ArA run by reducing TxA2 formation as a metabolite of ArA