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Abstract

An Efficient Method for the Synthesis of Bis(indolyl)methane Catalyzed by Nickel (II) Iodide

A simple mild, efficient synthetic methodology developed for the preparation of Bis(indolyl)methanes catalyzed by NiI2 in MDC medium at room temperature. Several substituted aldehydes with indoles under this reaction condition is elucidated. The features of this methodology are shorter reaction time, less equivalence of the reagent, clear reaction profile and simple work up procedures.