GIANO is a cryogenic cross-dispersed spectrometer whose optics consist of aspheric aluminum mirrors, glass flats, cross-dispersing prisms and a grating fixed onto a ~1.5×1.0 m aluminum bench. The primary aim of the project is to achieve the highest possible image quality and spectral stability essential for precise radial velocity measurements. The instrument also includes other observing modes which are obtained by inserting a flat mirror or a prism at different positions in the optical path. This flexibility is achieved without affecting the stability and performances of the primary, high resolution mode. We describe here the cryo-mechanical design which has been optimized to these purposes.