The left-hander hasn't been able to solve the Yankees captain over the course of his career, allowing him to collect 15 hits in 33 career at-bats (.455) against him. Meanwhile, he also brings in a wretched 0-2 record and 13.00 ERA in two lifetime starts at the new Yankee Stadium.

The Mets are currently plus-123 road underdogs in the first game of the 2012 Subway Series in the MLB betting odds (courtesy of SBR Forum), while the total sits at 8.5.

Santana (3-2, 2.38 ERA) has been given a little extra time to recover, as the 33-year-old threw a career-high 134 pitches in his history-making effort. It's important to note that the club has won his last six outings with six days of rest.

The Yankees have won eight of their nine Friday games during the 2012 MLB season—success that could definitely continue due to their 6-3 record against the Mets at this ballpark. The Yankees have scored 52 runs and homered 16 times in that span.

Hiroki Kuroda (4-6, 3.82 ERA) is scheduled to make his 12th start for the Bronx Bombers but will have a hard time improving upon his 3-2 record and 3.41 ERA in five home starts this year. The right-hander is 1-5 with a 5.75 ERA in seven career appearances versus the Mets, surrendering four or more earned runs in four of those outings.

I'm going to predict a high-scoring affair in this contest, with the "over" moving to 15-7 in the last 22 meetings in the Bronx.