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Approximately 112 HIV-negative women, aged 18 to 50, will be enrolled in this multicenter study at four sites. Volunteers will be randomized to dapivirine (TMC120) vaginal gel or matching placebo gel. The volunteers will receive investigational product for a total of 42 days. Volunteers will be monitored on days 7, 28 and 42 for safety, tolerability and compliance.

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Ages Eligible for Study:

18 Years to 50 Years (Adult)

Sexes Eligible for Study:

Female

Accepts Healthy Volunteers:

Yes

Criteria

Inclusion Criteria:

HIV-negative

Willing to participate and sign an informed consent

Willing to be tested for HIV, use an experimental vaginal gel, and to be randomized to a study group that includes the possibility of being assigned to a placebo group.

Willing to use two forms of contraception during the study.

Willing to undergo pelvic examinations with colposcopy and photographic documentation according to the protocol throughout the study.

Have a regular menstrual cycle defined as having a minimum of 21 days and a maximum of 36 days between menses.

Willing to abstain from using any vaginal product (other than the study product or placebo).

Willing to be sexually abstinent from randomization until completion of Day 7 evaluations.