Tedesco was the most-sought-after studio guitarist in Los Angeles during the 1960s and 1970s. He performed with Frank Zappa, Cher, Barbra Streisand, Frank Sinatra, Elvis Presley, Ella Fitzgerald, and the Beach Boys > to list only a few. He played the themes to the TV shows The Twilight Zone (1959–65), The Mickey Mouse Club (1955–59), Bonanza (1959–73), Green Acres (1965–71), and M*A*S*H (1972–83) and the movies The Deer Hunter (1978), The Godfather, and Field of Dreams (1989). Tedesco was also an influential music educator.