GM Peas
Cause Allergic Damage in Mice
(Beyond Pesticides, December 12, 2005)
A decade-long project to develop genetically modified (GM) peas with
built-in pest-resistance has been abandoned after tests showed they
caused allergic lung damage in mice, reports NewScientist.com,
based on results published in the Journal
of Agricultural Food Chemistry (53:9023).

The researchers
- at Australia's national research organization, CSIRO - took the gene
for a protein capable of killing pea weevil pests from the common bean
and transferred it into the pea. When extracted from the bean, this
protein does not cause an allergic reaction in mice or people. But the
team found that when the protein is expressed in the pea, its structure
is subtly different to the original in the bean. They think this structural
change could be to blame for the unexpected immune effects seen in mice.

The work underlines
the need to evaluate new GM crops on a case-by-case basis, says Professor
Paul Foster of the Australian National University in Canberra, who led
the immunological work. He also calls for improvements in screening
requirements for genetically engineered plants, to ensure comprehensive
tests are carried out.

Jeremy Tager, Greenpeace
Australia's campaigner on genetic engineering, agrees. "These results
indicate the potential for unpredicted and unintended changes in the
structure of transferred proteins. And I'm not aware of any country
that requires feeding studies as part of its approval process."

Researchers found
that mice that ate transgenic pea seed developed antibodies specific
to the inserted protein. Some of these mice were later exposed to the
purified protein, either through injection into the blood, or by putting
the protein into their airways. This approach, which is a standard "multiple
immune challenge" procedure, is designed to determine if the immune
system is tolerant to a protein. The injected mice showed a hypersensitive
skin response, while the airway-exposed mice developed airway inflammation
and mild lung damage.

The effect was the
same whether the protein was taken from raw or cooked peas - so whether
the protein was active or denatured. "To my knowledge, this is
the first description of inducing experimental inflammation in mice"
with a GM food, Dr. Foster says. In the early 1990s, researchers engineered
a more nutritious strain of soya bean by adding a gene taken from brazil
nuts. But the project ended when it was discovered that the hybrid was
likely to trigger a major attack in people with brazil nut allergies.

Further investigations
by Foster's team revealed slight differences in the molecular structure
of the protein when it was expressed in the bean and in the pea. They
think this was caused by differences in the way the two plants produce
proteins - particularly in a step called glycosylation, which involves
adding saccharides to the protein.

According to Dr.
Foster, slight differences in protein synthesis might also occur in
other plants with other genes, meaning each new GM food should be very
carefully evaluated for potential health effects. "If a GM plant
is to go up for human consumption, there should be a detailed descriptive
list of how one should go about analyzing that plant," he says.

A number of other
recent studies have also shown worrisome health effects related to GM
crops. In May 2004 a British newspaper leaked secret research
done by Monsanto. The research showed that rats fed GE corn exhibit
health problems including kidney abnormalities and blood changes. None
of these abnormalities were present in rats that were fed non-GE corn
for the study.

In addition to a
small but significant number of studies showing adverse effects of GE
food, many problems have been observed and reported over the years by
farmers and other people who are in regular contact with GE products.
According
to Jeffery M. Smith, author of Seeds of Deception, “nearly
25 farmers in the US and Canada say that certain GM [genetically modified]
corn varieties caused their pigs to become sterile, have false pregnancies,
or give birth to bags of water. A farmer in Germany claims that a certain
variety of GM corn killed 12 of his cows and caused others to fall sick.
And Filipinos living next to a GM cornfield developed skin, respiratory,
and intestinal symptoms and fever, while the corn was pollinating. The
mysterious symptoms returned the following year, also during pollination,
and blood tests on 39 of the Filipinos showed an immune response to
the Bt toxin—created by the GM corn.”

TAKE
ACTION: To protect yourself and your family, eat organic
when possible. American consumers have a right to choose for themselves
what kind of food they eat, and the U.S. government is acting irresponsibly
by denying that knowledge and that choice. Take two minutes to take
action on this issue by sending an online letter: go to The Center for
Food Safety's website to automatically send
a pre-written letter to the FDA demanding thorough safety testing
and mandatory labeling of GE products. Also check out the Institute
for Responsible Technology's website for information on how to pressure
manufacturers and food providers to stop producing and providing
GE food.