On 9 May 2001, just two days before the general elections in Italy, during his daily prime time 10-minute TV show Il Fatto, broadcast on Rai Uno, Biagi interviewed the popular actor and director Roberto Benigni, who gave a hilarious talk about Silvio Berlusconi declaring his preference for the other candidate, Francesco Rutelli from the Olive Tree coalition.[2]

Biagi's defenders argue that a public service should provide pluralism, and that a country where government prevents opposing ideas from being voiced on air is a régime.

The issue of Berlusconi's motives for entering politics in the first place emerged in an interview that he gave with Biagi and Indro Montanelli, stating "If I don't enter politics, I will go to jail and become bankrupt."[3]

On 22 April 2007, 86-year-old Enzo Biagi made his TV comeback on the RAI with RT - Rotocalco Televisivo, a current affairs show which is broadcast on Raitre. At the opening of the show, he declared:

Good evening, sorry if I am a bit emotional, maybe it is visible. There has been a technical problem, and the break has lasted five years.

Until shortly before his death he was also a columnist for the daily Italian newspaper Corriere della Sera, which he had worked for since the early 1970s.