Vincent Funari, director of the Genomics Research Core at Cedars Sinai in Los Angeles, discusses the huge demand that he is seeing from scientists at his facility for sequencing on the Ion PGM Sequencer and the Ion Proton Sequencer. Dr. Funari uses the Ion Proton Sequencer to study gene regulation using RNAseq, ChipSeq, and miRNA sequencing technologies in human conditions like diabetes or neuromuscular disease. He uses the Ion PGM Sequencer for 16S sequencing and for mutation identification in targeted cancer gene panels like lung cancer.

The Seibold Lab is focused on identifying genetic determinants and biomarkers of complex lung diseases, including asthma and pulmonary fibrosis. Dr Seibold's lab recently used the Ion Proton™ Sequencer for an asthma biomarker project.

Three researchers — Joe Boland, NCI; Dr. Jeff Reid, Baylor College of Medicine; Dr. Richard Allcock, University of Western Australia — were among the first to use the new Ion Proton™ Sequencer. In the video, they discuss the system's throughput, ease-of-use, speed and affordability.

Rapid innovation and flexibility of the PGM™ and Proton™ Sequencers drives the cancer genome research laboratory into the future

Dr. Boland discusses their exome sequencing pipeline using the Ion PGM™ System and their initial experience using the Ion Proton™ System for this exome sequencing pipeline, including their first run over 10 Gb

Ion PGM™ and Proton™ Sequencer data

Dr. Richard Allcock, an associate professor at the School of Pathology and Laboratory Medicine at the University of Western Australia, discusses his experience with the Ion PGM and Ion Proton sequencers at ASHG, including data from his initial Ion Proton sequencer runs.

Total RNA transcript analysis on the Ion Torrent™ platform: insight into functional ncRNA in cancer

Dr. Triche discusses transcriptome sequencing on the Ion Proton™ System at the 24:24 minute mark.