Fate Therapeutics Granted Exclusive License By The Regents of the University of California to Stem Cell Modulators for Osteo-Regeneration

tent cells that can differentiate into a variety of cell types includ... ... Having an industry partner is essential to a successful translational... ...Dr. Parhami continued For example with traumatic bone injuries suc...

tent cells that can differentiate into a variety of cell types, including osteoblasts, chondrocytes, myocytes and adipocytes. Dr. Parhami's discovery of specific pathways and small molecules that can induce differentiation to mature, bone-forming osteoblasts offers a new mechanism of intervention, which may be applied to treat a number of bone injuries and conditions, including non-union fracture, spinal fusion or osteoporosis. By collaborating with the foremost researchers and clinicians in the field of adult stem cell biology, Fate Therapeutics is continuing to expand its leadership position in the discovery and development of SCMs for regenerative medicine.

"Having an industry partner is essential to a successful translational drug discovery project, and we are excited about our collaboration with Fate Therapeutics to realize the full potential of our discoveries," said Dr. Parhami. "Our work has uncovered novel strategies and mechanisms for lineage-specific differentiation to an osteoblast phenotype. The ability to activate specific populations of stem cells in the body to promote bone regeneration may have many orthopedic clinical applications."

Dr. Parhami continued, "For example, with traumatic bone injuries, such as non-union fractures where the break in the bone cannot be healed without medical intervention, patients must undergo complicated surgeries and long recovery times. In the case of degenerative bone diseases, such as osteoporosis, current therapies focus on blocking bone degeneration rather than inducing formation. Being able to promote bone growth with novel osteogenic small molecules represents the next-generation of therapeutic agents for orthopedic medicine."

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