In different town, Strong Bad wishes that Marzipan would rock, picturing her playing an electric guitar. The guitar closely resembles "Mom", a guitar custom built for George Lynch and later produced by ESP Guitars. It is unknown if Marzipan has ever played an electric guitar; however, as mentioned above, it seems as though Carol is capable of making an electric guitar resonance in the song "Cool Things" and in One Two, One Two.

The Ukulele is used by Marzipan to play Hawaiian music for her luau. This is a more appropriate instrument than Carol to accompany Strong Sad's Polynesian prose. This instrument sports the letter "M", standing either for "Marzipan" or as the monogram of the instrument's own (unknown) name.

The Cheat's keyboard is a CasioSk-1 portable sampling keyboard. The Cheat has played the Strong Badia National Anthem, a background beat for Strong Bad's chart-topping hit "Song About Sibbie," and the acoustics for "Everybody Knows It" on it.

The Cheat's keyboard appears to have an extra key between E and F and two extra keys between B and C.

According to Strong Bad in the email guitar, if he had a band, The Cheat would play keyboards.

The Cheat plays a trap set in the band Cool Tapes. In Cool Things and Weclome Back he plays a drum set with a crash cymbal, hi-hat, floor tom, snare drum and bass drum. He has "Cool Tapes" written on his bass drum head. Similarly, The Cheat portrays himself playing a set of Simmons electronic drums in the video for Everybody to the Limit. Since The Cheat lacks visible feet, it is unclear how he can operate the bass pedal and hi-hat.

Strong Bad first claimed to be able to play an electric guitar in the Strong Bad Email guitar, but he didn't demonstrate this. Later, in rock opera Strong Bad is seen playing a Gibson V-Factor. According to Strong Bad, he is schooled both in rhythm and solo playing styles (and his performance in "vacation", while a little rusty, seems to confirm this). The V-Factor is an understandable choice for Strong Bad, as it was the guitar of choice for heavy metal bands in the late '80s and early '90s before falling out of vogue during the "grunge" era in favor of the Fender Stratocaster.

Homestar Runner plays a floor tom in the email do over. He plays it to help Strong Bad serenade Ali and Ali's sister. He plays it with only one stick and hits the head and the rim a couple of times, producing different pitches. It's possible that this is The Cheat's drum (from his Cool Tapes drum set).

In Most in the Graveyard, Homestar Runner dresses up as the titular role of the 1988 film Young Einstein, complete with the Young Einstein's prototypical electric guitar, which is featured in the movie poster.

Homsar plays a theremin in Strong Bad's band DÖI during Baddest of the Bands. It's likely the theremin belongs to Homsar, as Strong Bad has no idea what it is when he first sees it. As a particularly large version of the instrument, Homsar plays it by flying in circles around it. Curiously, however, Homsar appears to be singing the note, rather than playing the instrument.

Strong Mad's bass is an instrument that Strong Mad plays in the band Cool Tapes with Marzipan and The Cheat. Based on the body shape, neck and head style, and its relatively small size, it appears to be a Höfner 500/1, the bass popularized by Paul McCartney. It is black and has Strong Mad's initials on the headstock.

He was first seen playing the instrument in Cool Things as the band recorded their first Cool Tapes song. He later is seen playing it again in a topiary garden during the band's midwestern tour.

In Baddest of the Bands, Strong Bad mentions that Strong Mad's bass is literally a "Heavy Bass", as the strings are apparently made out of the cables used to hold suspension bridges up.

Bubs's Keytar is based on a Yamaha SHS-10 FM digital keyboard, whose most common variation is red and features colored buttons. With low-quality sounds and a $100 price tag, it was practically a toy, but had professional features like MIDI out, pitch-bend, and a two-digit LED display to indicate patch/program changes.

The only significant difference between Bubs's keytar and a real SHS-10 is that Bubs's only has 24 keys, while the real one has 32.

Pom Pom plays an electronic keyboard. In Baddest of the Bands, he forms a band with Homestar Runner named PomStar, though he already had a highly-successful career as an instrumentalist, previously producing an album named Food-Related Love. He hired Homestar to ad-lib lyrics to his music, but, given Homestar's tendency to have a brain-freeze in mid-song, was forced to dictate lyrics to him while playing the keyboard at the Battle of the Bands contest. It is not clear why he cannot perform his own lyrics, given that the other characters have no trouble understanding him, though Strong Bad regards him as being unable to sing.

As heard in "Not Talkin' 'bout Butter," and Lappynapped!, The King of Town plays "guitar, apparently!" The King also claimed in Lappynapped! to own "seventeen guitars, with a combined total of forty-three necks," which would require most of his guitars to be "triple necked". Such guitars exist, but are not standard production models, and would have to have been custom made. This is more likely a blatant lie. In Baddest of the Bands, The King of Town is seen playing a guitar for Strong Bad's band, DÖI.

After Homestar breaks the rap song video in Fish Eye Lens, a four-string banjo appears next to Coach Z. It appears more sophisticated than the one played by Old-Timey Bubs, but it still curiously lacks a tailpiece.