Protester John Walters of Oklahoma City holds a sign urging Gov. Mary Fallin to issue a stay in the execution of two inmates, near the Governor's Mansion in Oklahoma City on Tuesday, April 29, 2014. A botched execution that used a new drug combination left an Oklahoma inmate writhing and clenching his teeth on the gurney Tuesday, leading prison officials to halt the proceedings before the inmate's eventual death from a heart attack. (AP Photo/The Oklahoman, KT King)

Hossein Dabiri with Oklahoma Coalition Against the Death Penalty holds a sign protesting the death penalty at the State Capitol in Oklahoma City, Tuesday April 29, 2014. Oklahoma prison officials halted the execution of an inmate after the delivery of a new three-drug combination on Tuesday failed to go as planned. (AP Photo/The Oklahoman, Steve Gooch)

McALESTER, Okla. (AP) — An Oklahoma death row inmate writhed, clenched his teeth and appeared to struggle against the restraints holding him to a gurney before prison officials halted an execution in which the state was using a new drug combination for the first time. The man later died of a heart attack.

Clayton Lockett, 38, was declared unconscious 10 minutes after the first of three drugs in the state's new lethal injection combination was administered Tuesday evening. Three minutes later, he began breathing heavily, writhing, clenching his teeth and straining to lift his head off the pillow. Officials later blamed a ruptured vein for the problems with the execution, which are likely to fuel more debate about the ability of states to administer lethal injections that meet the U.S. Constitution's requirement they be neither cruel nor unusual punishment.

The blinds eventually were lowered to prevent those in the viewing gallery from watching what was happening in the death chamber, and the state's top prison official later called a halt to the proceedings. Lockett died of a heart attack shortly thereafter, the Department of Corrections said.

"It was a horrible thing to witness. This was totally botched," said Lockett's attorney, David Autry.

Questions about execution procedures have drawn renewed attention from defense attorneys and death penalty opponents in recent months, as several states scrambled to find new sources of execution drugs because drugmakers that oppose capital punishment — many based in Europe — have stopped selling to U.S. prisons and corrections departments.

Defense attorneys have unsuccessfully challenged several states' policies of shielding the identities of the source of their execution drugs. Missouri and Texas, like Oklahoma, have both refused to reveal their sources and both of those states have carried out executions with their new supplies.

Tuesday was the first time Oklahoma used the sedative midazolam as the first element in its execution drug combination. Other states have used it before; Florida administers 500 milligrams of midazolam as part of its three-drug combination. Oklahoma used 100 milligrams of that drug.

"They should have anticipated possible problems with an untried execution protocol," Autry said. "Obviously the whole thing was gummed up and botched from beginning to end. Halting the execution obviously did Lockett no good."

Republican Gov. Mary Fallin ordered a 14-day stay of execution for an inmate who was scheduled to die two hours after Lockett, Charles Warner. She also ordered the state's Department of Corrections to conduct a "full review of Oklahoma's execution procedures to determine what happened and why during this evening's execution."

Robert Patton, the department's director, halted Lockett's execution about 20 minutes after the first drug was administered. He later said there had been vein failure.

The execution began at 6:23 p.m., when officials began administering the midazolam. A doctor declared Lockett to be unconscious at 6:33 p.m.

Once an inmate is declared unconscious, the state's execution protocol calls for the second drug, a paralytic, to be administered. The third drug in the protocol is potassium chloride, which stops the heart. Patton said the second and third drugs were being administered when a problem was noticed. He said it's unclear how much of the drugs made it into the inmate's system.

Lockett began writhing at 6:36. At 6:39, a doctor lifted the sheet that was covering the inmate to examine the injection site.

"There was some concern at that time that the drugs were not having that (desired) effect, and the doctor observed the line at that time and determined the line had blown," Patton said at a news conference afterward, referring to Lockett's vein rupturing.

After an official lowered the blinds, Patton made a series of phone calls before calling a halt to the execution.

"After conferring with the warden, and unknown how much drugs went into him, it was my decision at that time to stop the execution," Patton told reporters.

Lockett was declared dead at 7:06 p.m.

Autry, Lockett's attorney, was immediately skeptical of the department's determination that the issue was limited to a problem with Lockett's vein.

"I'm not a medical professional, but Mr. Lockett was not someone who had compromised veins," Autry said. "He was in very good shape. He had large arms and very prominent veins."

The American Civil Liberties Union of Oklahoma, which was not a party in the legal challenge to the state's execution law, called for an immediate moratorium on state executions.

"This evening we saw what happens when we allow the government to act in secret at its most powerful moment and the consequences of trading due process for political posturing," said ACLU executive director Ryan Kiesel.

In Ohio, the January execution of an inmate who made snorting and gasping sounds led to a civil rights lawsuit by his family and calls for a moratorium. The state has stood by the execution but said Monday that it's boosting the dosages of its lethal injection drugs.

A four-time felon, Lockett was convicted of shooting 19-year-old Stephanie Neiman and watching as two accomplices buried her alive in rural Kay County in 1999. Neiman and a friend had interrupted the men as they robbed a home.

Warner had been scheduled to be executed two hours later in the same room and on the same gurney. The 46-year-old was convicted of raping and killing his roommate's 11-month-old daughter in 1997. He has maintained his innocence.

Lockett and Warner had sued the state for refusing to disclose details about the execution drugs, including where Oklahoma obtained them.

The case, filed as a civil matter, placed Oklahoma's two highest courts at odds and prompted calls for the impeachment of state Supreme Court justices after the court last week issued a rare stay of execution. The high court later dissolved its stay and dismissed the inmates' claim that they were entitled to know the source of the drugs.

By then, Fallin had issued a stay of her own — a one-week delay in Lockett's execution that resulted in both men being scheduled to die on the same day.

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