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Do you have rescue disk that may allow you to boot into safe mode, if you do you may want to try that first. I realize that you are saying that as soon as you open C drive you are getting this error, however is the pc booting and passing post (power on self test) you will hear one single beep. If the machine is booting you should be able to start in safe mode and run a virus software program such as malwarbytes, combo fix. Let me know if at least the machine is booting.

Chkdsk to solve this problem? This seems to be an infection, not a disk problem.Use an antivirus, mbam, anything to scan the system. Check disk or system restore, will not solve it. In fact, using System restore, you can restore your system to an infected state, if at that moment, the virus was present into your system. For example, use avast to scan the system, it knows to scan inside the restore point.

I agree almost all of you it's a Virus infection.
Have you tried opening your drive C or D using the Address bar or use Salamander?
I think USB Virus Scan could get rid with this virus infection but for sure try Avast Free Edition. Download it and Schedule a boot time this will sure remove all threats in your system. Don't waste your time with Rescue Disc.

99 % sure its a autorun virus. When you did scan it was removed and you still have the autorun file, so you have to remove it. follow these steps if you want to remove it :

Run Task Manager (Ctrl-Alt-Del or right click on Taskbar)
1. Stop wscript.exe process if available by highlighting the process name and clicking End Process tree.
2. Then terminate explorer.exe process with the same way.
3. In Task Manager, click on File -> New Task (Run?).
4. Type "cmd" (without quotes) into the Open text box and click OK.
Type these following commands
del c:\autorun.* /f /s /q /a then press enter
del d:\autorun.* /f /s /q /a then press enter
del e:\autorun.* /f /s /q /a then press enter
replace the bold letter with the drive name Ex: C D E F G H as the number of your partitions
On each time it should appear that the file successfully deleted.
5. In Task Manager, click on File -> New Task "Run".
Type "regedit" and click OK.
6. Navigate to the following registry key:
HKEY_LOCAL_MACHINE\SOFTWARE\Microsoft\Windows NT\CurrentVersion\Winlogon
7. Check if the value name and value data for the key is correct (the value data of userint.exe include the path which may be different than C drive, which is also valid, note also the comma which is also needed):
Userinit=C:\WINDOWS\system32\userinit.exe
If the value is incorrect, modify it to the valid value data. For Temp access to your drive Click Start then run and write the drive letter then :\ Ex: C:\ and press enter it will open without this virus. I think it will work with you