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Researchers demonstrated that lncRNA PVT1 was upregulated and significantly associated with high-microvessel density and poor prognosis in gastric cancer. Through gain- and loss-of PVT1 expression, they found that PVT1 could induce angiogenesis within tumors, in addition to promoting tumor growth in vitro and in vivo. [Oncogene]
Abstract

The authors generated STIM1 fl/fl mice and vascular endothelial cell-specific STIM1 knockout mice using the Cre-loxP system, and conducted experiments using these mice to clarify the physiological role of STIM1 in vascular endothelial function and blood pressure. [Hypertens Res]
Abstract

While embryonic veins and cells of mesenchymal origin have been recognised as sources of embryonic lymphatic endothelial cells for many years, recent advances in technology have revealed the existence of additional sources of lymphatic endothelial cells important for embryonic lymphangiogenesis. Intriguingly, distinct progenitor cell sources appear to be employed in a tissue specific manner during development. [Curr Opin Immunol]
Abstract

STEMCELL Technologies announced a $45 million joint funding agreement between the Governments of Canada and British Columbia to help the company build a state-of-the-art advanced manufacturing facility. [STEMCELL Technologies Inc.]
Press Release

Five Johns Hopkins scientists, with specialties spanning computation, genetics, statistics and engineering, are among 83 others from 53 institutions in the U.S and eight other countries, who will share in a $15 million award from the Chan Zuckerberg Initiative. [Johns Hopkins University]
Press Release

When Phil Janowicz and Kristopher Larsen began their campaigns for a seat in the U.S. House of Representatives, they joined what appears to be a record number of Ph.D. scientists running for national office. But after spending months on the campaign trail, the two Democrats—an organic chemistry professor from southern California and a space physics researcher from Colorado, respectively—decided to drop out before a single ballot had been cast in their states. [ScienceInsider]
Editorial

The U.K. government said it will endeavor to keep pace with the European Union’s impending changes in clinical trial procedures, bringing some solace to those wondering how the two will stay aligned after Brexit starts in earnest next March. [Questex LLC.]
Editorial

Inder Verma, the prominent geneticist and cancer scientist who has made his mark on U.S. research for decades, has sexually harassed women for just as long, according to allegations from eight women. [ScienceInsider]
Editorial