Title (fr)

Publication

Application

Priority

GB 9900739 W 19990311

GB 9805520 A 19980317

Abstract (en)

[origin: WO9947508A1] Compounds of formula (I), pharmaceutically acceptable salts or in vivo hydrolysable esters thereof, wherein: Ring X is phenyl or a six membered heteroaryl ring containing one or two ring nitrogens where said nitrogens are optionally oxidised to form the N-oxide; R<1> and R<2> are substituents as defined within; R<3> and R<4> are defined within and are alkyl or halo alkyl or together form a cycloalkyl or halocycloalkyl ring; R<5> is a substituent as defined within; Y-Z is a linking group as defined within; are useful in the production of an elevation of PDH activity in a warm-blooded animal such as a human being. Pharmaceutical compositions, methods and processes for preparation of compounds of formula (I) are described.