The add-on effect of Tiotropium bromide to ICS/LABA combination inhaler for the patients with severe uncontrolled asthma

Acronym

Add-on effect of TIO for severe asthmatics

Scientific Title

The add-on effect of Tiotropium bromide to ICS/LABA combination inhaler for the patients with severe uncontrolled asthma

Scientific Title:Acronym

Add-on effect of TIO for severe asthmatics

Region

Japan

Condition

Condition

bronchial asthma

Classification by specialty

Medicine in general

Pneumology

Classification by malignancy

Others

Genomic information

NO

Objectives

Narrative objectives1

The aim of this study is to investigate the clinical usefulness of TIO, especially its add-on effect on lung function, among severe asthmatics who have already received treatment with high-dose ICS/LABA combination inhaler

Basic objectives2

Efficacy

Basic objectives -Others

Trial characteristics_1

Confirmatory

Trial characteristics_2

Pragmatic

Developmental phase

Not applicable

Assessment

Primary outcomes

add-on improvement of respiratory resistance and reactance measured by Mostgraph-01 after inhalation of TIO or salbutamol to usual treatment with ICS/LABA combination after 6 months treatment period.

Key secondary outcomes

ACT scores, FeNO values, and spirometry values were also compared before and after 6 months treatment with TIO treatment.