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2. How Tyclav® works in our body Amoxicillin is a semisynthetic antibiotic with in vitro bactericidal activity against Gram-positive and Gram-negative bacteria. Clavulanic acid is a beta-lactam, structurally related to the penicillins, which possesses the ability to inactivate some beta-lactamase enzymes commonly found in microorganisms resistant to penicillins and cephalosporins.

The formulation of amoxicillin and clavulanic acid in TYCLAV protects amoxicillin from degradation by some beta-lactamase enzymes and extends the antibiotic spectrum of amoxicillin to include many bacteria normally resistant to amoxicillin.

4. What are the dosage & administration of Tyclav®?Dose of Tablets: Adults and children over 12 years: The usual adult dose is one Tyclav® 625 Tablet every 12 hours or one Tyclav® 375 Tablet every 8 hours. For more severe infections and infections of the respiratory tract, the dose should be one Tyclav® 1 g Tablet every 12 hours or one Tyclav® 625 Tablet every 8 hours.

Dose of Injections: Adults Usually 1.2 g every 8 hours, increased in more severe infections to 1.2 g every 6 hours. Adult dosage for surgical prophylaxis The usual dose is 1.2 g at induction, for high risk procedures (e.g., colorectal surgery) up to 2-3 further doses of 1.2 g may be given every 8 hours. Children 0 to 3 months: 30 mg/kg every 8 hours (every 12 hours in the perinatal period and in premature infants). 3 months to 12 years: Usually 30 mg/kg every 8 hours increased in more serious infections to 30 mg/kg every 6 hours.

5. What are the contraindications of Tyclav®History of Penicillin hypersensitivity. Attention should be paid to possible cross sensitivity with other β-lactam antibiotics e.g. cephalosporins.

6. What are the adverse effects of Tyclav®Side effects, as with Amoxicillin, are uncommon and mainly of a mild and transitory nature. Diarrhoea, pseudomembranous colitis, indigestion, nausea, vomiting and candidiasis have been reported.

7. What would be the storage condition of Tyclav®Store at a cool & dry place, away from light. Keep out of reach of children..