Yes, but... The Allegra (fexofenadine) is a long acting, non-sedating anti-histimine. If the itching hasn't been controlled, it is ok to take Benadryl (diphenhydramine) which is a short acting and sedating anti-histimine- so be aware of the potential for drowsiness.....Limit the Benadryl to one or two tablets per day, if continuing the allegra (fexofenadine).