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Chapters authored

Cannabinoid pharmacology has been explored as a therapeutic option for handling pathologies and conditions of varying nature. In regard to neurological disorders, cannabinoid chemistry has been explored for the regulation of hyperkinetic symptoms, anti-inflammation, neuroprotection, and neurodegeneration, a collective goal of many preclinical studies. The enhancement and improvement of the endogenous cannabinergic responses of the human body in both physiological and pathological conditions, together with the overall consequential effects of the modulation of its elements, are currently under strict scrutiny and undeniably possess incalculable value that might support the hypothesis aiming to improve the endocannabinoid tone with therapeutic purposes. Therefore, this chapter reviews the mechanisms known to be present in the course of several disorders of the basal ganglia, as well as the available treatments exploring this novel approach.