Project abstract for group arriagae

Subcellular Studies of Aging

Aging is a process that has disparate effects on a population of cells, even within a single organism. This work focuses on differences in the aging process, which can be observed with better resolution at the organelle and protein level to understand the cellular impact. The researchers aim to improve upon existing techniques - such as quantitative proteomics - and help to mature new techniques - such as mass cytometry - to improve their understanding of how aging impacts cellular populations. This research is particularly valuable to conditions that have distinct aging components, such as the three most widespread neurodegenerative diseases of Alzheimer's, Huntington's, and Parkinson's.