A pharmacologist discovers a new fungal metabolite with unusual antimicrobial properties. It naturally concentrates in the endosomes, lysosomes, and phagolysosomes of cells and directly kills microorganisms (eg, Mycobacterium tuberculosis) that are normally resistant to degradation in the phagolysosomes. The metabolite has the undesirable effect of increasing the pH within phagolysosomes. Which of the following processes will be primarily affected?

A)Class I MHC molecule peptide loading

B)Class II MHC molecule peptide loading

C)Peptide binding to T-lymphocyte receptor αβ

D) Peptide binding to T-lymphocyte receptor γδ

What is the answer and why? FYI ppl reading this...I'm going to post like 30 questions online today These are the questions that I simply do not understand. I would really appreciate your help. I need a 15 point increase by the end of the month. Hopefully this helps everyone.

A 7 yr old boy drinks cocoa and watches TV while petting his cat. He watches while his mother bakes fragrant cinnamon rolls while the stereo plays Mozart's string quartet in the background. Which of the following sensory modalities goes directly to the cortex without going into the thalamus.

During an experiment 500mg of both drug X and Y are simultaneously administered IV, the serum concentration of both drugs after bolus administration is 5 mg and 2.5mg respectively. Assuming no drug interactions. Which of the finding regarding the drug Y is compared with drug X?

25) a healthy 54 year old woman undergoes an exercise stress test. During the moderate phase of the exercise, her pulse is 140/min, respirations are 25/min, & bp is 130/90 mmHg. Which of the following is the relative proportion of coronary oxygen delivery during the rest & during the exercise times?

During an experiment 500mg of both drug X and Y are simultaneously administered IV, the serum concentration of both drugs after bolus administration is 5 mg and 2.5mg respectively. Assuming no drug interactions. Which of the finding regarding the drug Y is compared with drug X?

A 42-year-old man needs a kidney allograft .His lymphocytes are examined by the mized lymphocyte reaction with killed stimulator cells from himself and from each of 5 prospective donors. A donor with which of the following thymidine incorporation values (cpm) will be most compatible ? (the patient has a thymidine incorporation value of 425 /cpm)

A 42-year-old woman comes to the physician for a follow-up examination after she received two increased blood pressure readings on different days. Her blood pressure now is
140192 mm Hg. Physical examination shows no other abnormalities. In addition to considering pharmacotherapy, the physician recommends a low-sodium diet Which of the following
initial statements is the most appropriate approach to educating this patient about decreasing her sodium intake?
o A) "The Internet is a great way to learn about methods to decrease sodium in your diet"
o B) "Do you know what kinds of foods are high in sodium?"
o C)" will send you a brochure outlining the low-sodium diet you will need to follow."
o D) ''You must see a nutritionist to discuss decreasing your sodium intake"
o E) ''You need to lower your intake to fewer than three grams of sodium daily"

A 42-year-old woman comes to the physician for a follow-up examination after she received two increased blood pressure readings on different days. Her blood pressure now is
140192 mm Hg. Physical examination shows no other abnormalities. In addition to considering pharmacotherapy, the physician recommends a low-sodium diet Which of the following
initial statements is the most appropriate approach to educating this patient about decreasing her sodium intake?
o A) "The Internet is a great way to learn about methods to decrease sodium in your diet"
o B) "Do you know what kinds of foods are high in sodium?"
o C)" will send you a brochure outlining the low-sodium diet you will need to follow."
o D) ''You must see a nutritionist to discuss decreasing your sodium intake"
o E) ''You need to lower your intake to fewer than three grams of sodium daily"

A 42-year-old man needs a kidney allograft .His lymphocytes are examined by the mized lymphocyte reaction with killed stimulator cells from himself and from each of 5 prospective donors. A donor with which of the following thymidine incorporation values (cpm) will be most compatible ? (the patient has a thymidine incorporation value of 425 /cpm)

A) 312
B) 1542
C) 2505
D) 15.389
E) 27.482

thymidine incorporatn values (TIV) is the indicator of immunogenicity,so greater value of TIV test of donor indicates unsatisfactory match btwn donor and recipient MHC class II,which will cause rejection of the graft.
This means the donor with least value of TIV will be the best donor