With the deepening acknowledge on the relation between tumour driver genomes and clinical treatment, NSCLC therapy has revolutionary changed. So this kind of patients could survive more comfortably. The treatment mode changed from chemotherapy to the combining treatment of genotype-oriented and chemotherapy. Meanwhile, the clinical researches of maintenance treatment, second-line treatment, immunochemistry (especially the antibody) treatment carried out vibrantly. The author expounds and analyzes the current situation and progress in NSCLC treatments.