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This year the Minnesota iGEM team is tackling the piquant challenge of biosynthetic saffron production in yeast. We will use the production of saffron as a means to explore the use of polycistronic constructs and to develop a generalized, computational model of the productivity of these constructs. We will perform several tests using viral 2A sequences to investigate multi-enzyme biosynthesis pathways through polycistronic construction. Throughout this project, we will refine a computational model for polycistronic pathways via a system of mutual feedback between the experimental and the computational. Finally, to place our project in a more human context, we are planning several outreach initiatives that will continue to open the door for dialogue between the research community and general public.