The binding specificity between C8 beta and C8 alpha subunits is determined by a cooperative interaction of the N-terminal thrombospondin type 1 module and the membrane attack complex/perforin (zeige PRF1 Proteine) domain.

C8 alpha and C8 beta have correspondingly similar roles in MAC-mediated lysis of erythrocytes and bacterial killing. C8 gamma is not required for complement-mediated killing of Gram-negative bacteria.

Cell cycle induction by C5b-9 in aortic endothelial cells is RGC-32 (zeige C13orf15 Proteine) dependent and this is in part through regulation of Akt (zeige AKT1 Proteine) and growth factor release.

C8B Protein Überblick

Protein Überblick

C8 beta is one of the three subunits that comprise the component 8 (C8) of the complement system. C8 participates in the formation of Membrane Attack Complex that results in the lysis of cells. Patients with C8B deficiency are prone to bacteria infection.