Miss Greening - a strong opponent of a new runway at Heathrow - has been replaced by former Conservative Chief Whip Patrick McLoughlin after less than a year in the job and will take over the lower-profile role as International Development Secretary.

MOVING JOBS

Jeremy Hunt to Health Secretary

Patrick McLoughlin to Transport Secretary

Andrew Mitchell to Chief Whip

Andrew Lansley to leader of the House of Commons

Justine Greening to International Development Secretary

Owen Paterson to Environment Secretary

Ken Clarke to Minister without Portfolio

Baroness Warsi to Foreign Office minister

Damian Green to police minister. Mark Harper to immigration minister

Mark Hoban to employment minister. Michael Fallon to business minister

Speaking outside No 10, Mr Hunt said he was "incredibly honoured" to take charge of the Department of Health.

"It is a huge task and the biggest privilege of my life," he told the BBC.

Mr Lansley, the architect of controversial reforms to the NHS in England, has effectively been demoted to the more junior role of leader of the House of Commons.

Mr Clarke also takes a lesser role as minister without portfolio in the Cabinet Office, where he will act as a government "wise head" offering advice to Mr Cameron on issues including economic strategy.

He has been replaced by employment minister Chris Grayling, who was shadow home secretary before the 2010 election and is regarded as being to the right of Mr Clarke on justice issues.

Mr Clarke denied the move was a humiliation and he was "pleasantly surprised" to remain in cabinet.

He added: "At my age you do occasionally have to step down from a heavy departmental role before you suddenly realise you can no longer quite handle it."

What the prime minister has done is fired and hired, like any business leader, to attempt to address some of the weaknesses.

Among other changes, former Northern Ireland Secretary Owen Paterson becomes the new Environment Secretary, while Wales Office minister David Jones has been promoted to Welsh Secretary.

Baroness Warsi has lost her job as Conservative Party co-chairman but will continue to attend cabinet in the dual role of Foreign Office minister and minister for faith and communities.

Below cabinet level, Solicitor General Edward Garnier, defence minister Gerald Howarth, prisons minister Crispin Blunt and Children's minister Tim Loughton have all been axed, while policing minister Nick Herbert has resigned after reportedly turning down a move to the Department for the Environment, Food and Regional Affairs.

But Paul Deighton, chief executive of the London 2012 organising committee, will be given a peerage and become a Treasury minister. Treasury minister Chloe Smith moves to the Cabinet Office. She is replaced by Sajid Javid.

'No change'

All five Liberal Democrat cabinet ministers, including Business Secretary Vince Cable, will remain in their posts.

But there are changes lower down the Lib Dem ranks. Former cabinet minister David Laws - who resigned over his expenses in 2010 - has returned to the government as a junior education minister.

He replaces Sarah Teather, who is leaving the government - along with Lib Dem care services minister Paul Burstow and defence minister Nick Harvey.

But there are promotions for Norman Lamb and Jo Swinson, both close to Mr Clegg. Jeremy Browne moves from the Foreign Office to the Home Office.

STAYING PUT

Deputy Prime Minister Nick Clegg

Chancellor George Osborne

Foreign Secretary William Hague

Home Secretary Theresa May

Education Secretary Michael Gove

Defence Secretary Philip Hammond

Business Secretary Vince Cable

Work and Pensions Secretary Iain Duncan Smith

Chief Secretary to the Treasury Danny Alexander

Energy Secretary Ed Davey

Scottish Secretary Michael Moore

Communities Secretary Eric Pickles

Attorney General Dominic Grieve

Pressure has been growing on Mr Cameron in recent months, with several Conservative MPs accusing the coalition of not doing enough to promote economic growth.

In response to Tuesday's changes, backbencher Peter Bone said Mr Cameron seemed to be "listening to his party" and the new team had a more "traditional look".

But Labour said there would be no change in economic policy with George Osborne remaining in place.