The ASPCA has been rocked by a series of high-profile board resignations, including Yankees president Randy Levine, after internal disagreements over the direction of the historic humane society.

Directors of American Society for the Prevention of Cruelty to Animals, founded in 1866, started an exodus because they believe some in the organization are “more focused on social standing than the animals.”

We’re told that board members and longtime animal-welfare advocates who quit recently include Levine, Post columnist Cindy Adams and Marsha Perelman, a former ASPCA board chairman.

Page Six reported that the ASPCA had struggled to find a new president to replace outgoing leader Ed Sayres — despite the $555,824-a-year salary for the job.

A source told us, “The board was unable to settle on a new president for months, because the business people on the board could not agree with others who appeared to be more concerned about what they’ll wear to the annual Bergh Ball,” the group’s annual gala.

On May 2, the ASPCA announced that its senior vice president Matthew Bershadker would take over as president and CEO, which appears to have coincided with some of the board members’ resignations, Perelman had resigned earlier, we’re told.

Levine confirmed his departure and said in a statement, “I love animals, and I remain completely committed to helping animals, but I believe it was time for me to do it through a different vehicle or organization.”

Adams told us, “I love animals, and if it comes to discussing the ASPCA, I will let my dogs do the barking.”

An ASPCA rep said of the departures, “We are grateful for their service and many contributions to the ASPCA over the years,” adding, “The ASPCA’s board unanimously elected Mr. Bershadker, who has led the animal welfare group’s anti-cruelty work around the country . . . His outstanding record speaks for itself.”