Despite being in different divisions, these two teams met in Week 1 of last season. The Bills smoked the Chiefs, 41-7, in a game that saw Eric Berry lose his sophomore year to a torn ACL.

One year later, Berry is back, but the Chiefs are still missing healthy defenders. Their offense looks pretty healthy, though. There’s a chance the Buffalo Bills’ new defensive guys remember how much they’re being paid and get the stats to reflect that money in this game.

They will be at home, so there is a stronger chance that it could happen than if they were in Kansas City.

But after giving up 48 to the Jets, I wouldn’t count on it to happen so quickly. Neither fantasy defense is an attractive option heading into their matchup.

Quarterbacks

In his 2011 showing against the Chiefs, Ryan Fitzpatrick threw four touchdowns on the road. However, he only had 208 passing yards and just lost one of his leading receivers (David Nelson) for the season.

He didn’t turn the ball over and the Chiefs will be without starting free safety Kendrick Lewis, so he’s worth a play if you’re desperate.

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Ryan Fitzpatrick, Buffalo Bills

Matt Cassel’s day at the office against the Bills in 2011 was not so thrilling. The Chiefs quarterback had 22 completions but just 119 passing yards.

Unlike Fitzpatrick, Cassel will actually have an additional weapon in this game. Sophomore Jonathan Baldwin will make his first appearance against the Chiefs.

I’d try to stay away from both of these quarterbacks if possible. They combined for five interceptions in Week 1 and each have strong running games behind them to lean on.

Receivers

The Bills’ starter opposite Steve Johnson, David Nelson, will miss all but the first game of the 2012 season. That may result in additional attention for Johnson from his quarterback.

But it will result in additional attention from defenses, as well. Johnson’s a No. 3 WR in this game.

The Chiefs’ Jonathan Baldwin missed his first shot at the Buffalo Bills during his rookie season but went without a target in Week 1. His fantasy impact in the second game is therefore in serious question.

Either Kansas City determines that his involvement could have prevented such a nasty result in the first week, or it will continue to work the ball to Dexter McCluster and Dwayne Bowe.

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Dwayne Bowe, Kansas City Chiefs

The only two receivers I would be interested in starting for this game are Dwayne Bowe and Steve Johnson. McCluster could be a nice play in PPR leagues, but it shouldn’t be necessary to dig that deep with all 32 NFL teams in action.

Running Backs

Now, this is where it gets interesting.

Jamaal Charles and Peyton Hillis combined for 23 carries in Week 1, which is encouraging considering that the Chiefs lost by 16. Charles did most of his damage in the second quarter.

He had 68 of his 87 rushing yards in that period, and the Chiefs were within a field goal at halftime.

I’d much rather start Charles (16 carries in Week 1) than Hillis (seven), but the best bet at RB in this game should be C.J. Spiller of the Buffalo Bills.

With Fred Jackson sidelined, Spiller should see more touches than Charles or Hillis individually. As the backup to Jackson in 2011, Spiller recorded 16 rushing yards and a touchdown on five carries against the Chiefs.

But he is currently the highest-scoring running back league-wide in 2012. He should be a strong No. 1 RB option in Week 2.

Tight Ends

Scott Chandler of the Buffalo Bills might be Ryan Fitzpatrick’s favorite target against the Chiefs. If the defense won’t let Steve Johnson beat them, Chandler and Spiller will be up to the task.

The tight end scored twice against the Chiefs last year. He’s worth a fantasy start, but I wouldn’t put a Chiefs tight end in my lineups this week.