Covering the whole development process for the global biotechnology industry

Bioprocessing begins upstream, most often with culturing of animal or microbial cells in a range of vessel types (such as bags or stirred tanks) using different controlled feeding, aerating, and process strategies.

Beginning with harvest of material from a bioreactor, downstream processing removes or reduces contaminants to acceptable levels through several steps that typically include centrifugation, filtration, and/or chromatographic technologies.

Drug products combine active pharmaceutical ingredients with excipients in a final formulation for delivery to patients in liquid or lyophilized (freeze-dried) packaged forms — with the latter requiring reconstitution in the clinical setting.

Many technologies are used to characterize biological products, manufacturing processes, and raw materials. The number of options and applications is growing every day — with quality by design (QbD) giving impetus to this expansion.

Even as it matures, the biopharmaceutical industry is still a highly entrepreneurial one. Partnerships of many kinds — from outsourcing to licensing agreements to consultancies — help companies navigate this increasingly global business environment.

Thursday, February 12, 2015 Daily Archives

Lonza, a global leader in biological and cell therapy manufacturing and TiGenix, an advanced biopharmaceutical company focused on developing and commercializing novel therapeutics from allogeneic expanded adipose-derived stem cells (eASCs) in inflammatory and autoimmune diseases, announced today an agreement for the supply of TiGenix’s eASC product, Cx601. Under the agreement, Lonza will manufacture material for the Phase 3 trial of Cx601 in the US at Lonza’s cell therapy production facility in Walkersville, Maryland (US). Cx601 is a locally-injected suspension of…

International Pharmaceutical Expo (INTERPHEX), the premier pharmaceutical and biopharmaceutical event dedicated to innovation, technology and knowledge, and sponsored by the Parenteral Drug Association (PDA), and BioProcess International, a monthly magazine devoted to the development, scale-up, and manufacture of biotherapeutics and biodiagnostics, today announced the addition of a Poster Hall held during INTERPHEX 2015 taking place April 21-23, Javits Center, New York, New York. Posters will be available on the show floor on Tuesday and Wednesday, April 21-22 from 9:00am-5:00pm. A…

“We have always been rather unconventional” Back in 1965, Alexander Hawrylenko opened the Hawrylenko Technik in a vacant Basel kiosk. Fifty years later the name of the biotechnology specialist still incorporates his initials. By now, INFORS HT has become one of the world’s most prestigious developers and manufacturers of shakers, bioreactors and software. However, in this anniversary year 2015 the Swiss-based company is not just celebrating its own achievements but above all giving something back to its staff and to…