Pseudomonas aeruginosa is one of the most commonly considered gram-negative aerobic bacilli in the differential diagnosis of a number of probable gram-negative infections. Consideration of this organism is important because it causes severe hospital-acquired infections, especially in immunocompromised hosts, is often antibiotic resistant, complicating the choice of therapy, and is associated with a high mortality rate.

The principles of antimicrobial treatment of infections caused by P. aeruginosa will be reviewed here. Discussion on the epidemiology, pathogenesis, clinical manifestations, diagnosis, and treatment of specific pseudomonal infections are discussed separately:

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