Right tackle Jack Conklin will also be sidelined for a significant chunk of time. He'll miss a few weeks with a knee injury, though he will avoid surgery, according to NFL Network. The injury will likely force him to miss the rest of the regular season, thrusting Dennis Kelly, who started at right tackle in Week 10 while Conklin sat with a concussion and played 35 percent of snaps on Thursday against the Jaguars, into a starting role.

Titans running back Derrick Henry (22) runs away from Jaguars cornerback Jalen Ramsey (20) for his fourth touchdown of the game in the third quarter at Nissan Stadium Thursday, Dec. 6, 2018, in Nashville, Tenn. George Walker IV / Tennessean.com

Titans running back Derrick Henry (22) celebrates his third touchdown with his teammates in the third quarter at Nissan Stadium Thursday, Dec. 6, 2018, in Nashville, Tenn. George Walker IV / Tennessean.com

Titans running back Derrick Henry (22) goes in for the team's first touchdown in the first quarter against the Jaguars at Nissan Stadium Thursday, Dec. 6, 2018, in Nashville, Tenn. Andrew Nelles / Tennessean.com

Titans running back Derrick Henry (22) slaps hands on the field after the team's 30-9 win over the Jaguars at Nissan Stadium Thursday, Dec. 6, 2018, in Nashville, Tenn. George Walker IV / Tennessean.com

Titans defensive tackle Jurrell Casey (99) celebrates the team's 30-9 win as he leaves the field after the game at Nissan Stadium Thursday, Dec. 6, 2018, in Nashville, Tenn. George Walker IV / Tennessean.com

Titans defense stops Jaguars running back Leonard Fournette (27) on a fourth down play on the goal line in the first half at Nissan Stadium Thursday, Dec. 6, 2018, in Nashville, Tenn. George Walker IV / Tennessean.com

Titans running back Derrick Henry (22) goes in for the team's first touchdown in the first quarter against the Jaguars at Nissan Stadium Thursday, Dec. 6, 2018, in Nashville, Tenn. Andrew Nelles / Tennessean.com

Titans running back Derrick Henry (22) rushes for a first down defended by Jaguars safety Ronnie Harrison (36) in the first quarter at Nissan Stadium Thursday, Dec. 6, 2018, in Nashville, Tenn. George Walker IV / Tennessean.com

Alex Rivera, of Nashville, checks out his freshly painted face before the game between the Tennessee Titans and the Jacksonville Jaguars at Nissan Stadium in Nashville, Tenn., Thursday, Dec. 6, 2018. Andrew Nelles / Tennessean.com

Wesley Gransmaison, 11, hands out scarfs to fans before the game between the Tennessee Titans and the Jacksonville Jaguars at Nissan Stadium in Nashville, Tenn., Thursday, Dec. 6, 2018. Andrew Nelles / Tennessean.com

Security keeps watch as fans begin to arrive before the game between the Tennessee Titans and the Jacksonville Jaguars at Nissan Stadium in Nashville, Tenn., Thursday, Dec. 6, 2018. Andrew Nelles / Tennessean.com

During a Friday afternoon conference call, Titans coach Mike Vrabel did not have an update on Smith, Conklin on any of the other Titans who were injured and did not return against Jacksonville, including wide receiver Tajae Sharpe (ankle) and linebacker Brian Orakpo, who hurt what appeared to be his left arm.

Smith injured his knee on Derrick Henry's 99-yard touchdown run, which tied for the longest in NFL history. The tight end played a crucial part in making it happen, successfully blocking two Jaguars defenders to help carve an inside hole for Henry to dart through. He then cut to the left, raced up the sideline, and the rest was history.

Smith, though, stayed down before heading to the locker room.

The silver lining for the Titans is the emergence of Anthony Firkser. The tight end out of Harvard has 13 catches for 165 yards and a touchdown over the last four games. He's caught all 16 of his targets this season.

"He’s a tough guy to guard," Vrabel said. "He practices well. He’s a converted wide receiver. He runs really good routes. The quarterbacks always talk about the confidence that they have in him to throw him the football."

After three games in 11 days, the Titans (7-6) now have some extra time off before heading to New York (4-8) to face the Giants on Dec. 16.

"It’ll be good to get some time off, get some guys healed up," Vrabel said. "I have to do a good job of managing the schedule and still getting us ready for the Giants but trying to get everybody back that we could possibly get back to try to help us win another game."

Cam Batson's muffed punt a 'technique issue'

Cameron Batson muffed a punt, recovered it and retreated into the end zone before being tackled for a safety.

Batson's costly gaffe shrunk the Titans lead to 7-2 late in the first quarter. Vrabel, who deployed Adoree' Jackson as the team's punt returner for the rest of the game, said he hoped Batson would give the Titans a spark in the return game.

"There was a technique issue where you’re catching the ball and you get turned sideways," said Vrabel, who compared it to fielding a ground ball in baseball, and emphasized the importance of squaring up. “Sometimes when you’re not square, those bad hops can get you.

"I think for Cam, it was technique issue and then he made a bad decision. He tried to make a play. He tried to make up for it. Probably instead of just burying it there and just do whatever he could to rectify the situation, I think it went from a technique issue to a bad decision... But we have a lot of confidence in Cam. He’s a young player that we like. He’ll get more opportunities and he’ll continue to do stuff for us."

Quinton Spain bounces back

Spain played only 46 percent of the team's offensive snaps against the Jets in Week 13 before Vrabel pulled him. On Thursday, though, he was one of three Titans — the others being quarterback Marcus Mariota and center Ben Jones — to play 100 percent of the offensive snaps.

"It’s great for anybody that maybe didn’t have their best performance or they’re working their way back through something. Q’s one of those guys," Vrabel said. "That group played well. They gave Marcus a chance to throw it when we had to throw it and like I mentioned, when you run the ball as successfully as we did, a lot of credit has to go to the line. That’s a good front, good players, and so they did a nice job and Q was certainly a part of that."

Reach Erik Bacharach at ebacharach@tennessean.com and on Twitter @ErikBacharach.