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Cover: The relationship between gut microbiota and hypertension is a novel area of research focus. Although clinical studies have hinted at the relationship between gut microbiota and hypertension for the past 30 years, recent advances in molecular sequencing technology and metabolomics have driven further research that demonstrates a definitive link between gut microbiota and hypertension in rat models of hypertension. Physiological Genomics has published one such report, on the Dahl rat model and microbiota, and an editorial by J. W. Honour on the historical perspective of the relationship between gut microbial dysbiosis and hypertension. For details see Mell B, Jala VR, Mathew AV, Byun J, Waghulde H, Zhang Y, Haribabu B, Vijay-Kumar M, Pennathur S, Joe B. Evidence for a link between gut microbiota and hypertension in the Dahl rat. Physiol Genomics 47: 187–197, 2015; first published 31 March 2015
(10.1152/physiolgenomics.00136.2014) and Honour JW. Historical perspective: gut dysbiosis and hypertension. Physiol Genomics 47: 443–446, 2015; first published 21 July 2015 (10.1152/physiolgenomics.00063.2015).