AntiarrhythmicsAntiarrhythmics: Palpitations have been reported with amygdalin supplementation, according to secondary sources. Slow pulse has also been noted anecdotally.

HypotensivesHypotensives: Hypotension has been reported with amygdalin supplementation, according to secondary sources.

Vitamin CVitamin C: According to a case report, an initial dose of 3g of amygdalin administered to a woman taking 4,800mg of vitamin C daily led to severe cyanide poisoning (5). Vitamin C is known to increase conversion of amygdalin to cyanide in vitro and reduce body stores of cysteine, which is used to detoxify cyanide.

Beta-glucosidase-containing foodsBeta-glucosidase-containing foods: Beta-glucosidase, one of several enzymes that catalyze the release of cyanide from amygdalin, is present in the human small intestine and many common foods. Toxicity studies in rats have shown orally supplemented amygdalin to release significant amounts of cyanide (1). Theoretically, consumption of foods rich in glucosidase concomitantly with amygdalin supplementation may raise the risk of cyanide poisoning.

Vitamin C-containing foodsVitamin C-containing foods: According to a case report, an initial dose of 3g of amygdalin administered to a woman taking 4,800mg of vitamin C daily led to severe cyanide poisoning (5). Vitamin C is known to increase conversion of amygdalin to cyanide in vitro and reduce body stores of cysteine, which is used to detoxify cyanide.

The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.