Lethal injection became the standard method of execution in 2000. The electric chair is still used, though only if the prisoner requests it.

FSP sits in the center of several other prisons. It is surrounded by New River Correctional Institution, New River O-Unit, FSP West Unit, and sits across the river from Union Correctional Institution. Even though Union Correctional Institution is on the same property, immediately north-west of FSP, the county line (with Union County) runs in between the two, which makes Raiford the United States Postal Service address city of Union Correctional Institution, while Starke is the USPS address city of Florida State Prison.

FSP is Florida's only prison that is officially named "prison", with the other institutions being named "Correctional Institutions" (or "Correctional Facility" if it is a privately contracted prison).

Manuel Pardo – executed on December 11, 2012. Ex-police officer who was charged and subsequently found guilty of murdering 6 men and 3 women, during a series of robberies over a three-month period in early 1986.

Lynyrd Skynyrd's song "Four Walls of Raiford" tells the story of a convict who escapes from the Florida State Prison; The convict is a veteran returning from the Vietnam War and pleads his case that he was wrongly convicted for armed robbery and asks to be buried with full honors if he gets caught.