Cepharanthine inhibited the endolysosomal trafficking of free-cholesterol and low-density lipoprotein in HUVECs by binding to Niemann-Pick disease, type C1 protein and increasing the lysosomal pH. The blockade of cholesterol trafficking led to a cholesterol-dependent dissociation of mTOR from the lysosomes and inhibition of its downstream signaling. [Cancer Lett]
Abstract

Researchers investigated the role of sirtuin 3 (SIRT3) on endothelial cell (EC) glycolytic metabolism, angiogenesis, and diastolic function. They tested the hypothesis that loss of SIRT3 in ECs impairs endothelial glycolytic metabolism and angiogenesis and contributes to myocardial capillary rarefaction and the development of diastolic dysfunction. [J Mol Cell Cardiol]
Abstract

As Germany reels from an unexpected surge for the far right in the elections, researchers don’t expect much effect on the country’s generous support for science. But with smaller parties standing to gain political influence, battles over issues such as the regulation of gene-edited organisms and how to cut greenhouse-gas emissions could grow fiercer. [Nature News]
Editorial

The UK BioIndustry Association (BIA) and the Medicines and Healthcare Products Regulatory Agency (MHRA) brought together experts from across the sector to discuss some hot topics and important developments that are having an impact on the changing and dynamic UK life sciences ecosystem. [Medicines and Healthcare Products Regulatory Agency]
Press Release

The number of researchers applying for Europe-funded Marie Curie fellowships in the United Kingdom has dipped slightly since the country’s vote to leave the European Union, data released to Nature show. But there is no evidence yet of a sharp collapse in interest, which some scientists had feared in the wake of the Brexit referendum. [Nature News]
Editorial

One of Erin O’Shea’s first moves as Howard Hughes Medical Institute (HHMI) president was committing $25 million a year to support postdocs from underrepresented groups. Her hope was that they would eventually change the color—and culture—of their departments as they moved into leadership positions, in addition to serving as role models for the next generation of scientists. [ScienceInsider]
Editorial