Origins of Sickle Cell

Increasing fetal hemoglobin in people with homozygous sickle cell alleviates all symptoms of SCD.
The Google map shows four independent genetic origins, or haplotypes, of SCD in different regions (ellipses) and the subsequent migrations of populations (white arrows). The solid white arrow is to signify the forced migration of Western Africa peoples as slaves to the Western Hemisphere. The four haplotypes (Se = Senegal, Be = Benin, Bantu, and Arab-India) all have the sickle cell mutation in exactly the same gene location, but other genetic differences associated with the haplotypes result in differences in the severity of SCD. The Arab-India group has a second mutation that keeps a fetal hemoglobin (HbF) gene active after birth, such that HbF is up to 45% of the total Hb including sickle hemoglobin (HbS). People of the Arab-India haplotype with 30% or more HbF have no clinical manifestations of SCD, revealing that increased HbF can offer a “cure.” Decreasing HbS and increasing HbF by using gene regulation therapy is the basis of SCCF’s cure.

Globe image of Africa and Asia is copyrighted by Google Earth and is used with permission.

Comments

sir janhit organization is working for welfare of the patients suffering with disease sickle cell. in my country millions of people suffering with sickle cell disorder and 5% tribal people die due sickle cell disorder and lack of improper care. india is the sovergnity country but the people living in the area of tribal is so backward they could not purchase the medicine $1 dollar.hence organization is working for cure and treatment of it .kindly provide any support to us if possible.
thanking you
mnkhairejanhitsanstha@gmail.com

Dear Janhit Sansta,
I am sorry to hear of the great suffering among India’s tribal peoples due to sickle cell disease. Thank you for sharing the description of this situation with all of us. It is our intent to make our treatment available in India for very little cost, as soon as possible after it is approved for human use. I wish you the very best,
Robert H. Broyles, PhD
President, SCCF

sir as per janhit sanstha working report and study from the sickle society u.k.we found that sickle cell is an disorder of RBCs during the manufacturing of blood from bone marrow. the main cause is the mutation carry out dring protein systhesis in cell. due change in the genetic material or DNA means position of disorder on globulins this cause te sickle cell . as per demo from sickle cell society the number of cell breakdown due to restriction in circulation. it aslo affected on the circulation , respiration because cell is the fundamental units of life.

Dear Margaret Kiwanuka,
We hope to start clinical trials in mid-2012. One of the advantages of our treatment is that the cost should be low enough for everyone to afford.
Robert H. Broyles, PhD
SCCF President/Lead Scientist

my organization is working in multihealthcare at tribal area such as T.B.,MALARIA,HEPATITIS,HIV,AIDS,SICKLE CELL. we found that mostly healthcare counciling is require at tribal level on pregannacy and newborne cases.so as to need of the patients govt/ngo should keep strong provision for treatment at the level of pregnancy,newborne .sothat it will helps to control the future problems of health.