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Any sharp drill bit with an electric hand drill will work on CF. If you needed to drill hundreds of holes, a carbide bit would probably last longer than the ordinary high speed steel or TiN coated hihgh speed steel. CF is abrasive and wears cutting tools quickly.

If the tube is very thin/fragile you may want to make up a small "doubler" piece and drill through that so the strength remains (like the diamond device that surrounded water bottle bolt holes) as some fibres will be broken by the drilling

Another thing you will probably want to do is make a jig for drilling at an angle, asuming you're drilling for cables or the like. What exactly are you doing this for?

You can use a small block of wood, drill a pilot hole at an angle in the block of wood, then secure that to the frame and drill a pilot hole into the frame through the block. Then re-drill the block at your desired size and repeat against the frame.