Also included in the voice cast are Hugh Laurie, Will Arnett, Seth Rogen, Rainn Wilson, Stephen Colbert, and Paul Rudd.

A reinvention of '50s era monster movies, the pic will be the toon studio's first film produced in 'Ultimate 3-D' technology, reports Variety.

Witherspoon leads an all-star cast in the film, voicing the role of Susan Murphy, a California girl who is unexpectedly clobbered by a meteor full of outer space gunk and mysteriously grows to 50 feet tall.

She is captured by the military and held in a secret government compound where the military has been quietly rounding up other monsters over the years.

The group consists of brilliant but insect-headed Dr. Cockroach, Ph.D. (Laurie) and macho half-ape, half-fish the Missing Link (Arnett).

Wilson plays Gallaxhar, Colbert is the president of the U.S., Sutherland portrays General W.R. Monger and Rudd is Susan's boyfriend, Derek.

Rob Letterman and Conrad Vernon will direct the film while Lisa Stewart is producing, and Jill Hopper and Latifa Ouaou co-produce.

'Monsters vs. Aliens' is slated for release by Paramount Pictures on March 27, 2009.