You can turn off clipboard support when there is no active editing cell by setting:
this.gridDataBoundGrid1.Model.CutPaste.ClipboardFlags = 0;
When a cell is editing, the embedded cell control handles these keys, and you can handle it at that cell level. For example, this code zaps the context menu (that has these short cut keys) for the TextBox cell control.
Dim c As Control = Me.grid.CellRenderers("Currency").Control
c.ContextMenu = New ContextMenu