en fr Critical periods for the growth and the mammary development with an obesogenic food supply, in a rabbit and mouse models : implication of the leptin Périodes critiques pour la croissance et le développement mammaire lors

Abstract : Women’s nutrition can have long-term effects on mammary development and on the development and the health of the offspring. Leptin may play a major role during these processes. In the present work we show that leptin synthesis in the mammary gland slightly increases during pregnancy, but largely increases during lactation. We also show that, in the rabbit, milk consumption from obesogenic-fed dams promote the later effects of an obesogenic diet and leads to an abnormal mammary development observed in the offspring. We also highlight the synthesis and the mammary secretion of leptin in a heterologous cellular model. We also evaluate the intra-species variability as well as the growth considering two nutritional windows: obesogenic feeding from the puberty or from the birth, in two lineages of mice, FVB-N and C57BL -6.This work shows that the consumption of altered maternal milk has long-term effects by influencing the growth and the mammary development of the offspring, in rabbit