Introduction: The aim of this study was to investigate the effect of 8 weeks of compound exercises with simultaneous omega-3 and l-carnitine supplementation on serum levels of Visfatin in type II Diabetic Women. Materials and Methods: This quasi-experimental study included a pre-test and post-test with 5 experimental groups and one control group. Participants of the study were type II diabetic women, average age 52.7±1.6 years and body mass index 29.82±4.35 kg/m², who were randomly divided into 6 groups of 10 individuals each: 1. Exercise+placebo 2. Exerci­se+omega-3, 3. Exercise+L carnitine, 4. Exercise+ omega 3+ L- carnitine, 5. L-carnitine+omega-3 and 6. The control group. Omega-3 supplementation groups daily consumed 2000 mg of omega-3 and L-carnitine group 500 mg L-carnitine either. Training included 3 sessions per week, each session consisted of 30 minutes of aerobic exercise with 60-70% of maximum heart rate and 30-40 minute of circular resistance training with 60% of repetition maximum (1RM). Results: T-test showed that visfatin levels in groups 3, 4 and 5 (p≤0.01), fasting glucose and glycosylated hemoglobin in groups 2 and 1, and 4 and 5 (p≤0.001) and insulin in group 5 was significantly reduced (p≤0.02). Comparison showed no significant differences between the groups p>0.05. Conclusion: The results of this study, show that compound exercises, along with and simultaneous supplementation of Omega-3 and with l-carnitine, are appropriate stimuli to curtail visfatin levels and reduce risk factors in type 2 diabetic women.