DryLab®-assisted HILIC-separation of mAb's

In a recent publication, Balázs Bobály and his colleagues successfully demonstrated the HILIC-separation of a complex mixture of monoclonal antibodies. This was done by using HPLC-modeling software, in this case DryLab®4.

While their previous works in protein analysis have described the proficiency of DryLab in the context of many chromatographic applications such as reversed phase, hydrophobic interaction and ion exchange, Bobály et al. are the first to describe a DryLab separation per hydrophilic interaction chromatography (HILIC).

Their results prove the excellent predictive accuracy of in-silico modeling.

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Molnár-Institute invites you to join our intensive DryLab®4 Training for UHPLC Method Development

Molnár-Institute will be hosting three days of intensive DryLab HPLC method development training in Berlin, Germany.
The event will take place from 19-21 March 2018.
This course provides extensive training on UHPLC method modeling using the DryLab4 software package. Participants learn our comprehensive approach to method development, starting with basic one-dimensional model calculations and continuing through multi-dimensional (3D) model optimizations.
Part of this course is devoted to the topic of Quality by Design (QbD) in UHPLC method development.

Molnár-Institute will be exhibiting at PittCon from February 27th – March 1st 2018, in Orlando, FL

Progress has been made this year to connect DryLab®4 to some popular Chromatography Data Systems (CDS's) and instruments (such as Waters, Shimadzu, Thermo, etc.) to automate the development of UHPLC methods. This is a great help for users, as they don't need to manually set up the 12 methods, which are typically required by DryLab®4 for its unique 3D-modeling of the critical resolution of UHPLC separations.

Analysis of mAb's and ADC's

The team of Szabolcs Fekete and Davy Guillarme (Univ. Geneva, CH) contributed two new papers about the analysis of monoclonal antibodies (mAb’s) and conjugated molecules in Journal of Pharmaceutical and Biomedical Analysis. The technique applied was Hydrophobic Interaction Chromatography (HIC), which seems to work with antibody-drug-conjugates (ADC’s) with great success, opening up new capabilities in the field of effective cancer treatment. The best separation conditions were found fast with the newest DryLab4-HPLC-method development software, developed by Molnár-Institute, Berlin. Analysis time was typically less than 10 min, method development time is approximately half a day.
Read more in our literature section!

New Knowledge Management Module

DryLab Knowledge Management offers comprehensive method documentation for better knowledge sharing. It automatically collects all relevant method data directly from DryLab and offers you a platform for comments and the justification of method criteria.

European Pharmaceutical Review Interviews Molnár-Institute at AAPS

Company President, Dr. Imre Molnár, speaks with Freddy White about the history of DryLab and how the software enables users in the pharmaceutical industry to conform to the FDA's analytical Quality by Design (QbD) requirements during HPLC method development.