Mass Effect 2 Original Videogame Score was released on January 18, 2010 and is the main soundtrack for the Mass Effect 2 video game.

Jack Wall, as lead composer of his audio production team "Wall of Sound", is credited for the composition and production of the Mass Effect 2 score. Team members included Sam Hulick, David Kates, Jimmy Hinson; and additional music, editing, and implementation was made by Brian DiDomenico. Wall, Hulick and Kates returned to work on the Mass Effect 2 video game score after having also worked on the original Mass Effect video game score, and ultimately the first Mass Effect Soundtrack.

On September 8, 2010, EA released Mass Effect 2: Atmospheric. It is a smaller soundtrack of ambient and atmospheric music from Mass Effect 2 that were missing from the original soundtrack. It is available through iTunes, Amazon and Rhapsody.

On October 5, 2010, EA released a second companion album to the Mass Effect 2 Original Videogame Score titled Mass Effect 2: Combat. It features mostly action and combat cues that were missing from the original score, however it does feature music from some cutscenes, most notably the ending. It is available through Amazon, iTunes, and Rhapsody.