Clinical Study on Mesenchymal Stem Cells Used in the Reconstruction Surgery of the Supraspinatus Muscle Lesions

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The prospective randomized clinical study investigating the effect of mesenchymal stem cells on tendon healing. The objective of the study is to demonstrate the effect of concentrated bone marrow stem cells ( MSCs ) to the healing of sutured tendon of the supraspinatus muscle in comparison to the same procedure performed without MSCs. We have postulated the hypothesis that MSCs enhance the healing of the sutured supraspinatus tendon to its humeral footprint.

presence of the supraspinatus tendon rupture on magnetic resonance imaging evaluated 2 years after the surgery, incidence of rerupture compared between group I- with the use of mesenchymal stem cells and group II- without the use of mesenchymal stem cells

ASES score- American Shoulder and Elbow Surgeons Standardized Shoulder Assessment Form [ Time Frame: 1 day before the surgery, 6 months postoperatively, 1 year postoperatively, 2 years postoperatively, 5 years postoperatively, 10 years postoperatively ]

Consists of two parts. The first part features a questionnaire filled in by the patients themselves, and included a visual analogue scale for pain and instability and assessment of ability to perform activities of daily living ( ADL ). The second part, which is completed by a doctor, represents an objective assessment of the conditions, and includes the evaluation of range of motion, specific physical characteristics, strength and stability. Score for the arm was then derived from the visual analogue scale for pain (50%) and the general score for ADL (50%).

Constant score [ Time Frame: 1 day before the surgery, 6 months postoperatively, 1 year postoperatively, 2 years postoperatively, 5 years postoperatively, 10 years postoperatively ]

Two parts: first- subjective evaluation of ADL ( activities of daily living ) from the patient's perspective, the second part is an objective assessment of range of motion and muscle strength performed by the physician

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