Stewart’s performance at the June 1-3 comedy and music festival — co-produced by his old bosses at Comedy Central — will mark the comedian’s first stand-up appearance on the West Coast in more than 15 years. The Lonely Island, the comedic musical trio made up of “Saturday Night Live” alums Andy Samberg, Akiva Schaffer and Jorma Taccone, will also perform live in concert for the first time.

Other musical performers on the Clusterfest bill include Salt-N-Pepa and Third Eye Blind, the San Francisco rock band fronted by Stephan Jenkins, though Superfly founder Jonathan Mayers noted more comedy/music crossover artists this year. Along with the Lonely Island — famous for musical “SNL” shorts including “Lazy Sunday” and “I’m on a Boat” — Reggie Watts and Bridget Everett will perform.

The second Clusterfest is produced by Comedy Central and Outside Lands Music and Arts Festival co-producers Superfly and Bay Area-based Another Planet Entertainment.

“It was such an incredible experience and it was so overwhelmingly positive, we couldn’t imagine any reason not to do it again, and not try to build on it,” said Comedy Central President Kent Alterman, who added that they didn’t hesitate to bring the festival back to San Francisco.

The name has changed to Comedy Central’s Clusterfest and there appear to be few repeat performers, but the basic template is the same. The SF Sketchfest team will also return to help with comedy programming.

Also back are the interactive attractions, including the return of a South Park-themed world and the replica of Paddy’s Pub from “It’s Always Sunny in Philadelphia.”