This work focuses on steroid receptors, including the androgen receptor (AR), the estrogen receptors (ERs) ERα and ERβ, known as the classical ERs, and GPR30, a recently described G protein-coupled estrogen receptor. Each ...

The acute phase serum protein C-reactive protein (CRP) is one of the major responding proteins during inflammation response in humans. CRP is a serum pattern recognition molecule that can bind to dead or damaged cells and ...

Autophagy is an immune effector response against a variety of intracellular pathogens, including Mycobacterium tuberculosis. Mycobacteria survive in macrophages by blocking maturation of the phagosome. Induction of ...

Polycyclic aromatic hydrocarbons (PAHs) and arsenic are both toxic contaminants that are widely distributed in the environment. Previous studies have shown that certain levels of PAHs and arsenic exposure individually can ...

Carbonylated (oxidized) proteins are known to accumulate in the brain of patients with multiple sclerosis (MS) and in the spinal cord of rats with acute experimental autoimmune encephalomyelitis (EAE). Yet, our knowledge ...

The purpose of the study was to identify factors that influenced health promotion behaviors in Latino/Hispanic men’s health, including their experiences and health concerns. Acculturation, emerging adulthood and health ...

The erbB1 receptor regulates cellular programs including proliferation, migration, and differentiation and is the prototypical receptor tyrosine kinase (RTK). The erbB family consists of four homologous transmembrane ...

Numerous epidemiology studies demonstrate that acute increases in air pollutants correlate with an increase in cardiovascular disease-related mortality. The pollutant diesel exhaust (DE) has been shown to impair both ...

Myogenic tone is an important regulator of blood flow and may contribute to peripheral vascular resistance and blood pressure. Myogenic tone is a luminal pressure-induced constriction of the vasculature that is mediated ...

Proteases, proteins which cleave peptide bonds in other proteins, are a large and varied group of proteins which regulate a variety of physiological processes. Methodologies to study proteases are often protease specific ...

Human adenoviruses (HAdV) are major causative agents of acute respiratory disease (ARD) worldwide. Military recruits and children are two of the populations most susceptible to HAdV infection in the United States. ...

In the United States, prostate cancer is the second most common reason for cancer death in men. No imaging methods currently exist which are specific for detecting, imaging, and treating extracapsular or metastatic prostate ...

Defining underlying molecular mechanisms exploited by cancer cells in their development and progression provides a necessary foundation for experimental therapeutics. The androgen receptor (AR) is a known therapeutic target ...

Cowpox virus (CPXV), a close relative of variola virus, the orthopoxvirus that causes smallpox, can suppress the immune system through a large array of immunosuppressive gene products. We developed a murine model in which ...

Infectious diseases are an increasing threat to shrimp farming industries worldwide and account for nearly $3 billion of annual economic loss. The need to devise novel approaches against these infectious agents is pressing, ...

Learning deficits in children following arsenic (As) exposure via drinking water have been epidemiologically described in the last decade. Arsenic is a persistent environmental toxin and exposure has been shown to perturb ...

The genus Flavivirus comprises viral species with positive sense, single stranded RNA genomes, most of which are transmitted by mosquitoes and ticks. During replication, RNA viruses have higher mutation rates than DNA ...