Pharrell and Chad met at a summer camp from the school of The Gifted and Talented in Virginia Beach, where Williams was a drummer and Hugo played tenor saxophone.[2] They were also both members of a marching band; Pharrell played kettle drum and Chad was a student conductor. In 1990 Chad and Pharrell formed a 4-piece "R&B type" group along with friends Shay and Mike Etheridge, which they named The Neptunes. Upon entering a local talent contest, they were discovered by Teddy Riley, whose studio was close to Pharrell's school.[3] After graduating from high school, they signed with Riley as a group.[4]

Through working with Riley, Pharrell went on to write a verse for Wreckx-N-Effect's 1992 #2 (billboard hot 100) hit "Rump Shaker". In 1994, Hugo and Williams had established themselves formally as a production duo under the previously used name "The Neptunes", and produced "Tonight's The Night" from Teddy Riley's group BLACKstreet's self-titled debut. Over the next three years they continued to produce occasionally. Some of the production, such as for SWV (1996) and Total (1996), had little resemblance to what would become their distinctive sound, while other songs such as Mase's 1998 No.8 (Billboard hot 100) hit "Lookin' At Me" (from the Harlem World album, 1997) showed clear signs the Neptunes sound was developing.

Their first major production hit, and the most clear beginning of the distinctive Neptunes sound, came with N.O.R.E.'s "Superthug" in 1998, reaching #36 on the Billboard Hot 100, and gaining them widespread attention for the first time. The duo then went on to work heavily with Kelis, producing her first album Kaleidoscope and Ol' Dirty Bastard's record Got Your Money, on which Kelis is featured. They achieved huge commercial success with tracks like Jay-Z's "I Just Wanna Love U (Give It 2 Me)", Mystikal's "Shake Ya Ass", and then-newly-renamed Diddy's single "D.I.D.D.Y". Other notable hits during their commercial rise were Busta Rhymes' "Pass The Courvoisier pt. 2" and Usher's "You Don't Have to Call".