REVERSIBLE ELECTROPORATION DEVICE FOR INDUCING CELL APOPTOSIS - A reversible electroporation device in which an electric pulse generator generates a sequence of electric pulses delivered to electrodes coupled to a tissue in which a process of reversible electroporation that generates cell apoptosis is to be performed. The device is configured to control the amplitude of the pulses and the number of the pulses delivered to the electrodes so that the amount of energy per weight unit (absorbed dose) applied to the tissue is in a range between a first lower limit value of about 3000 J/kg and a second upper limit value of about 4500 J/kg.

05-24-2012

20140148876

METHOD FOR CONTROLLING AN ELECTROPORATION DEVICE - A method for controlling an electroporation device configured for supplying an electrical power signal to a plurality of pairs of electrodes coupled to a portion of the human body, wherein the following steps are performed: detecting, in the course of an electroporation treatment, a condition of malfunctioning or fail for the pairs of electrodes for which at least one electrical parameter of the power signal supplied to the electrodes themselves has an anomalous value; storing an indicator of the pairs of electrodes in the fail condition; and selecting the pairs of electrodes in the fail condition and re-computing new parameters in order to implement a subsequent electroporation process.

05-29-2014

20140148884

HAND HELD ADJUSTABLE DEVICE - Hand held adjustable device comprising: a grip provided with an end portion; a plurality of needles which extend axially from the end portion and are made of electrically conductive material, and a device for adjusting the insertion depth of the needles in a tissue in which a cup-shaped body borne by said end portion of the grip is provided with an end wall having holes for the passage of said needles. A system for adjustment of the relative position between the cup-shaped body and the end portion provides an axial sliding of the cup-shaped body with respect to the end portion adjust the length of the portion of the needles protruding from said end wall and therefore the insertion depth in the tissue.

Giuseppe Marazzi, Milano IT

Patent application number

Description

Published

20100249414

CRYSTALLINE FORM II OF 7-(DIMETHOXY-METHYL) CAMPTOTHECIN, ITS USE AS INTERMEDIATE AND PRODUCTS OBTAINED THEREFROM - This invention relates to a process for preparing a crystalline form of (4S)-11-(dimethoxymethyl)-4-ethyl-4-hydroxy-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]qui-noline-3,14(4H,12H)-dione (also named 7-(dimethoxy-methyl)camptothecin). With the provision of a particular crystallization step, in appropriate way, a new crystalline form of the above compound is obtained. The process for the preparation of the polymorph Form II comprises transforming camptothecin to the corresponding 7-(dimethoxy-methyl)-camptothecin, and crystallizing it from methanol.

09-30-2010

Lucia Marazzi, Pavia (pv) IT

Patent application number

Description

Published

20110170870

Method and Device for Stabilizing the State of Polarization of a Polarization Multiplexed Optical Radiation - A device and method for stabilizing the state of polarization of polarization multiplexed optical radiation including an identified channel is disclosed. The device and method comprise providing to the polarization multiplexed optical radiation a first controllable polarization transformation to generate a first transformed optical radiation; detecting a first state of polarization of a first polarized portion with respect to a first polarization parameter; controlling the first controllable polarization transformation so that the first polarization parameter has a predetermined value independent of a polarization state of the polarization multiplexed optical radiation; providing to the first transformed optical radiation a second controllable polarization transformation to generate a second transformed optical radiation; detecting a second state of polarization of a second polarized portion; and controlling the second controllable polarization transformation so that the second state of polarization has a predefined value.

Lucia Marazzi, Milano IT

Patent application number

Description

Published

20110317238

METHOD AND APPARATUS FOR OPTICAL PHASE MODULATION - A method of phase modulating optical radiation by the steps of phase modulating the optical radiation by using a modulator having an extinction ratio in order to provide a multilevel phase shift key signal, and applying to each optical pulse a phase-shift having an absolute value depending on the extinction ratio and a sign depending, for each of the optical pulses, on the respective optical phase value. An apparatus implementing the method is also disclosed.

12-29-2011

Lucia Marazzi, Borgarello (pv) IT

Patent application number

Description

Published

20140029945

POLARIZATION STABILIZATION SCHEME FOR UN-COOLED SELF-TUNING CAVITY FOR COLORLESS ULTRA BROADBAND PON - An optical transmitter for a WDM (Wavelength Division Multiplexing) passive optical network (PON) and a WDM PON comprising such an optical transmitter are disclosed. An optical transmitter comprises first mirror and second mirrors at first end and second ends of a cavity; an optical amplifier positioned within the cavity upstream from the first mirror and for amplifying light polarized in a first polarization plane; an optical waveguide for transmitting light from the optical amplifier to the second mirror and vice versa; a first non-reciprocal polarization rotator upstream of the optical amplifier and downstream of the optical waveguide; and a second non-reciprocal polarization rotator upstream of the optical waveguide and downstream of the first mirror; wherein the first and second non-reciprocal polarization rotators rotate the polarization of the light such that light which re-enters the optical amplifier after having been reflected by the second mirror is polarized in the first polarization plane.

01-30-2014

Marcello Marazzi, Pandino Cr IT

Patent application number

Description

Published

20140067416

APPARATUS FOR QUANTIFYING AND DISPLAYING A PATIENT'S TIME BUFFER, BLOOD TREATMENT APPARATUS AND METHOD - An apparatus configured to quantify and display a time buffer for at least one patient during a blood treatment session is described. A blood treatment apparatus which includes such an apparatus or is in signal communication therewith, and a method for quantifying and presenting the time buffer for at least one patient at a blood treatment session are also described, as well as a computer program, a computer program product and a digital storage medium.