IMNM

iPSC and Mouse Neurocardiac Models (NS090364)

Specific Aims and Tasks

Utilize iPSC-derived cardiac myocytes and autonomic neurons as well as mouse models to determine whether heart rhythm disturbances are a cause of SUDEP in Dravet Syndrome, a severe childhood epilepsy with a high risk of SUDEP

Focus on SCN1A and SCN1B mutations and investigation of their effect on cardiac and autonomic neuron excitability