Depression is a condition characterized by persistent feelings of sadness or grief. It has become increasingly prevalent over the years, now affecting affects more than 16.2 million Americans. People who suffer from this condition also experience low energy, loss of appetite, and disinterest in things that they used to enjoy. Moreover, depression also increases the risk of suicide, alcohol and drug abuse, obesity, and chronic pain. To improve the quality of life of depressed patients, they often take antidepressants such as selective serotonin reuptake intake inhibitors (SSRIs). However, these are usually associated with side effects, which include sleep problems, headaches, weight gain, and increased risk of suicide. Because of these, researchers continue to search for natural alternatives that are both effective and safe.

The mango tree, especially its bark, is widely used in Ayurvedic and African medicine. It is commonly used to treat hypertension, insomnia, tumor growth, rheumatism, and depression. Previous research shows that mango bark is rich in bioactive compounds such as alkaloids, flavonoids, saponins, tannins, phenols, ascorbic acid, riboflavin, niacin, and thiamine. These phytochemicals might play a role in the plant’s different biological activities. However, there are limited studies that explore its antidepressant activity.

In this study, the researchers administered extracts from mango tree bark to mice. They then proceeded to observe the mice for depression- and anxiety-like behavior using the forced swim, tail suspension, and elevated plus maze tests. The team also tried to determine possible mechanisms of action by co-administering inhibitors of known neurotransmitter pathways used by antidepressant medications. They used the serotonin antagonists parachlorophenylalanine and metergoline, as well as yohimbine, and sulpiride, which block adrenaline and dopamine pathways, respectively.

From these experiments, they observed that the mango tree bark had potent antidepressant and anti-anxiety effects. These were possibly due to interactions with the receptors of serotonin, adrenaline, and dopamine since coadministration of the antagonists prevented improvements in the depression- and anxiety-like behavior of mice.

Other health benefits of mangoes

Leaves for improving diabetes — Although the mango fruit might be bad for people with diabetes because of its high sugar content, its leaves are a different story since they exhibit antidiabetic properties. Use them by first leaving them out to dry. Afterward, you should pulverize them into a powder, which you can take half a teaspoon of twice a day.

Fruits for preventing sunstroke — Mangoes have a high water content that makes them great for keeping the body hydrated. Drink a glass of mango juice or shake in the summer to keep sunstroke at bay.

Seeds for nosebleeds — Don’t throw away the seed of the mango once your done eating the fruit, especially if you suffer from nosebleeds. To immediately stop the bleeding, just put two to three drops of mango seed kernel juice to your nostrils.

Leaves for insect bites — Juice from mango leaves have anti-inflammatory properties that can help relieve insect bites.