I would recommend making an image periodically, perhaps using one of the programs mentioned at https://www.wilderssecurity.com/showthread.php?t=327781. You mentioned in the other thread that you're hesitant to make an image due to partition size issues; you could, however, devote 1 or perhaps 2 external drives for just image backups. The external drives devoted to imaging needn't ever be stored offsite. Just be sure to remember that if you restore an image, that you afterwards need to restore your data files from your most recent data files backup.

I make whole drive images and additionally back up my data separately. If CryptoLocker happened to me, I'd probably nuke the drive and restore back to the way it was before the infection. Other than the nuking tool (which I never use but have on hand), the other programs are in regular use.

From accounts I've read, CryptoLocker may not be all that difficult to remove. The issue is the encryption of one's data. But my backup preparations make that of little concern...