Glitches

On the PlayStation 2, the entrance to Big Smoke's Crack Palace can be blown off with any sort of high level explosive (Rocket Launcher's and Remote Grenades for example, regular Grenades and car explosions do not work) before End of the Line, which reveals Blue Hell. However, this was fixed when the game came out on the PC.

When shooting the statue of Big Smoke, as seen in the picture, the sparks that come out look a bit like blood.

Whereas Tenpenny destroyed the machinery in the drug lab during the events of End of the Line, it cannot be destroyed in normal gameplay.