Despicable Me is a 2010 American computer-animated 3D family comedy film from Universal Pictures and Illumination Entertainment that was released on July 9, 2010 in the United States. The first Illumination Entertainment production, it was directed by Pierre Coffin and Chris Renaud, based on an original story by Sergio Pablos.

The film stars the voice of Steve Carell as Gru, a super-villain who adopts three girls (the voices of Miranda Cosgrove, Dana Gaier, and Elsie Fisher) from an orphanage; and the voice of Jason Segel as Vector, a rival of Gru who steals the Great Pyramidof Giza. When Gru learns of Vector's heist, he plans an even greater heist to shrink and steal the Earth's moon.

It was entirely animated by the French animation studio Mac Guff, which was later acquired by Illumination Entertainment.

The film earned positive reviews from critics, and grossed over $543 million worldwide, against a budget of $69 million. A sequel, Despicable Me 2, is set to be released on July 3, 2013, followed by a spin-off featuring Gru's Minions as the main characters on December 19, 2014.