•Related Small Molecules:

Biological Activity

Technical Information

Purity & Documentation

References

Description

F16 is a small molecule that selectively inhibits proliferation of mammary epithelial, neu-overexpressing cells, as well as a variety of mouse mammary tumor and human breast cancer cell lines.
1, F16 induced cell cycle arrest in sensitive mouse tumor and human cancer cell lines.
2, Prolonged incubation with 3 uM F16 resulted in increased cell death of F16-sensitive cells but not of F16-resistant ones.
3, F16 caused apoptosis in A6 cells.
4, F16 caused a dramatic decrease in the number of cells in S phase and an increase in the percentage of cells in G1 phase.
5, F16 is capable of inhibiting oxidative phosphorylation and inducing mitochondrial transmembrane depolarization.

Solvent & Solubility

In Vitro:

DMSO : ≥ 31 mg/mL (85.59 mM)

*"≥" means soluble, but saturation unknown.

Preparing Stock Solutions

ConcentrationSolventMass

1 mg

5 mg

10 mg

1 mM

2.7608 mL

13.8041 mL

27.6083 mL

5 mM

0.5522 mL

2.7608 mL

5.5217 mL

10 mM

0.2761 mL

1.3804 mL

2.7608 mL

*Please refer to the solubility information to select the appropriate solvent.