Activity Monitoring Assessment of Opiate Withdrawal - 4

Summary

The purpose of this study is to determine if hyperactivity accompanies abrupt opiate
withdrawal in heroin addicts, to determine if computerized solid state activity monitors are
capable of quantifying hyperactivity, and to quantify the physical and affective symptoms
occurring during abrupt withdrawal in heroin addicts and morphine's capacity to alleviate
these symptoms.

Morphine administration is a medical problem characterized by compulsive opioid use that causes terrible negative consequences. The exact mechanisms of morphine-induced dependence and morphine withdra...

There is extensive literature regarding nicotine-opioid functional interactions. The possibility that use of nicotine products during adolescence might increase the risk of substance abuse such as mor...

The United States is in the midst of an unprecedented public health crisis, with annual morbidity and mortality data related to opioid use consistently increasing and appearing more worrisome. To miti...

Cebranopadol is a mixed NOP/opioid receptor agonist currently under development as innovative analgesic. In this study the liability of cebranopadol to produce opioid-type physical dependence has been...

Medical and Biotech [MESH] Definitions

Narcotics

Agents that induce NARCOSIS. This term is considered outdated due to imprecision but continues to be widely used. Originally, agents that caused somnolence or induced sleep (STUPOR); now, any derivative, natural or synthetic, of OPIUM or MORPHINE or any substance that has their effects. Narcotics are potent inducers of ANALGESIA and OPIOID-RELATED DISORDERS.

Opioid-related Disorders

Disorders related or resulting from abuse or mis-use of opioids.

Methadone

A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. It also has a depressant action on the cough center and may be given to control intractable cough associated with terminal lung cancer. Methadone is also used as part of the treatment of dependence on opioid drugs, although prolonged use of methadone itself may result in dependence. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)

Hydromorphone

An opioid analgesic made from MORPHINE and used mainly as an analgesic. It has a shorter duration of action than morphine.

Receptors, Opioid, Mu

A class of opioid receptors recognized by its pharmacological profile. Mu opioid receptors bind, in decreasing order of affinity, endorphins, dynorphins, met-enkephalin, and leu-enkephalin. They have also been shown to be molecular receptors for morphine.

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