Low Threshold Calcium Currents in TC cells (Destexhe et al 1998)

In Destexhe, Neubig, Ulrich, and Huguenard (1998) experiments and models examine low threshold calcium current's (IT, or T-current) distribution in thalamocortical (TC) cells. Multicompartmental modeling supports the hypothesis that IT currents have a density at least several fold higher in the dendrites than the soma. The IT current contributes significantly to rebound bursts and is thought to have important network behavior consequences. See the paper for details. See also http://cns.iaf.cnrs-gif.fr Correspondance may be addressed to Alain Destexhe: Destexhe@iaf.cnrs-gif.fr
Reference: 1 .
Destexhe A, Neubig M, Ulrich D, Huguenard J (1998) Dendritic low-threshold calcium currents in thalamic relay cells. J Neurosci18:3574-88 [PubMed]

Model Information (Click on a link to find other models with that property)

NEURON TUTORIAL FOR IMPLEMENTING SIMULATIONS OF THALAMIC RELAY NEURONS
Alain Destexhe
Laboratory for Computational Neuroscience
Unité de Neurosciences Intégratives et Computationnelles (UNIC)
Centre National de la Recherche Scientifique (CNRS)
91198 Gif-sur-Yvette, France
Formerly from (when this work was created):
Department of Physiology, Laval University,
Quebec G1K 7P4, Canada
Destexhe@iaf.cnrs-gif.fr
http://cns.iaf.cnrs-gif.fr/Main.html
This package is running with the NEURON simulation program written by Michael
Hines and available on internet at:
http://www.neuron.yale.edu/neuron/
http://neuron.duke.edu/
The package contains mechanisms (.mod files) and programs (.oc files) needed
to simulate different models of thalamocortical (TC) relay neurons, relative
to the paper:
Destexhe A, Neubig M, Ulrich D and Huguenard JR.
Dendritic low-threshold calcium currents in thalamic relay cells.
Journal of Neuroscience 18: 3574-3588, 1998.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9570789&dopt=Abstract
A postscript version of this paper, including figures, is available on
internet at
http://cns.iaf.cnrs-gif.fr/Main.html
PROGRAMS
========
tc1_cc.o c : current clamp in 1-compartment TC cell
tc3_cc.oc : current clamp in 3-compartment TC cell
tc200_cc.oc : current clamp in 200-compartment TC cell (intact cell)
tc200_vc.oc : voltage clamp in 200-compartment TC cell (intact cell)
tcD_cc.oc : current clamp in 8-compartment TC cell (dissociated cell)
tcD_vc.oc : voltage clamp in 8-compartment TC cell (dissociated cell)
MECHANISMS
==========
hh2.mod : fast sodium spikes (Na and K currents)
ITGHK.mod : T-type calcium current of TC cells
cadecay.mod : intracellular calcium dynamics
VClamp.mod : mechanism for single-electrode voltage-clamp
HOW TO RUN
==========
Use autolaunch on modeldb or:
unix platform:
To compile the demo, NEURON and INTERVIEWS must be installed and working on
the machine you are using. Just type "nrnivmodl" to compile the mechanisms
given in the mod files.
Then, execute the main demo program by typing:
nrngui mosinit.hoc
mswin platform:
Compile the mechanism (mod) files by using mknrndll. Then start the simulation
by clicking on mosinit.hoc in windows explorer.
back to any platform:
Once the menu and graphics interface has appeared, click on a simulation from
the Simulations of TC cells window. Then click on "Init and Run"
button to start the simulation on the RunControl window. If you do not see a RunControl
window you can bring it to the front by selecting it under Tools from the NEURON main menu.
For more information about how to get NEURON and how to install it, please
refer to the following sites:
http://www.neuron.yale.edu/neuron/
http://neuron.duke.edu/
For further information, please contact:
Alain Destexhe
Laboratory for Computational Neuroscience
Unité de Neurosciences Intégratives et Computationnelles (UNIC)
Centre National de la Recherche Scientifique (CNRS)
91198 Gif-sur-Yvette, France
Destexhe@iaf.cnrs-gif.fr
http://cns.iaf.cnrs-gif.fr/Main.html
Further updated 7/10/05 for button restart fix
.model version 10/28/02 updated to neuron 5.2.