Bone Density Medications

Bisphosphonate drugs are bone density medications (also called bone-modifying agents) used to help prevent bone loss (osteoporosis). They are also used as a bone-strengthening treatment for women with bone metastases.

Bisphosphonates are now used to treat some women with early breast cancer [9,116]. These drugs may lower the risk of breast cancer recurrence [117-118].

If you are postmenopausal (either naturally or through ovarian suppression) and will get chemotherapy or hormone therapy after breast surgery, your oncologist may recommend the bisphosphonate zolendronic acid (Zometa) as part of your treatment [116].

Zolendronic acid is given by vein (through an IV) every 6 months for 3-5 years.

Health risks

Talk with your oncologist about possible side effects and health risks that may occur while taking zolendronic acid.

Osteonecrosis of the jaw

Although mostly a concern for people with metastatic breast cancer who take high doses, bisphosphonate use increases the risk of osteonecrosis of the jaw, a serious jawbone disorder [92-93]. Before you start treatment with bisphosphonates, it’s a good idea to have a dental exam [92].