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Sunday, June 30, 2013

Used for divinatory and healing purposes in Latin American countries (esp. Mexico and Peru) ayahuasca is a plant-based brew, in the Amazons.
One of our students, Michelle Wilkie has tried it, and recounted her experience.

"It is very similar to a trip, and it can last 30 to 50 minutes". Everyone can react to it differently.

You can find out more about it here: "Insufflating DMT (commonly as a freebase or fumarate)
requires a higher dose than inhalation. The duration is markedly increased, and
some users report diminished euphoria but an intensified otherworldly
experience. A dose of approximately 70 to 120 mg of insufflated DMT will
induce medium to strong effects. If successful in containing this pain inducing
insufflation, the trip can last anywhere from 20 to 50 minutes, with
undefinable peak(s).

Injection

Injected DMT produces an experience that is
similar to inhalation in duration, intensity, and characteristics.

In a study conducted from 1990 through 1995, University of
New Mexico psychiatrist Rick Strassman
found that some volunteers injected with high doses of DMT reported experiences
with perceived alien entities. Usually, the reported entities were
experienced as the inhabitants of a perceived independent reality the subjects
reported visiting while under the influence of DMT.[13]
In a September 2009 interview with Examiner.com, Strassman described the
effects on participants in the study: "Subjectively, the most interesting
results were that high doses of DMT seemed to allow the consciousness of our
volunteers to enter into non-corporeal, free-standing, independent realms of existence
inhabited by beings of light who oftentimes were expecting the volunteers, and
with whom the volunteers interacted. While 'typical' near-death and mystical
states occurred, they were relatively rare."

Taken orally with an appropriate MAOI, DMT produces a long
lasting (over 3 hour), slow, deep metaphysical experience similar to that of psilocybin
mushrooms, but more intense.[7]
MAOIs should be used with extreme caution as they can have lethal complications
with some prescription drugs such as SSRI antidepressants, some
over-the-counter drugs,[93]
and many common foods.[96]

Induced DMT experiences can include profound
time-dilation, visual and auditory illusions, and other experiences that, by
most firsthand accounts, defy verbal or visual description. Some users report
intense erotic imagery and sensations and utilize the drug in a ritual sexual
context.[7][97][98]

Distinguish from 5-MeO-DMT

5-MeO-DMT, a
psychedelic drug structurally similar to N,N-DMT, is sometimes
referred to as DMT through abbreviation. As a white, crystalline solid, it is
also similar in appearance to DMT. However, it is considerably more potent
(5-MeO-DMT typical vaporized dose: 5–20 mg), and care should be taken to
clearly differentiate between the two drugs to avoid accidental overdose.[99]

Detection in body fluids

DMT may be quantitated in blood, plasma or
urine using chromatographic techniques as a diagnostic tool in clinical poisoning
situations or to aid in the medicolegal investigation of suspicious deaths.
Blood or plasma DMT levels in recreational users of the drug are generally in
the 10–30 μg/L range during the first several hours post-ingestion.[citation
needed] Less than 0.1% of an oral dose is eliminated
unchanged in the 24-hour urine of humans.[100][101]

Side effects

According to a "Dose-response study of N,N-dimethyltryptamine
in humans" by Rick Strassman, "Dimethyltryptamine dose slightly elevated
blood pressure, heart rate, pupil diameter, and rectal temperature, in addition
to elevating blood concentrations of beta-endorphin, corticotropin,
cortisol,
and prolactin. Growth hormone
blood levels rose equally in response to all doses of DMT, and melatonin
levels were unaffected."[53]

Conjecture

DMT
crystal at 400x magnification

Several speculative and yet untested
hypotheses suggest that endogenous DMT is produced in the human brain
and is involved in certain psychological
and neurological
states. DMT is naturally occurring in small amounts in rat brain, human
cerebrospinal fluid, and other tissues of humans and other mammals.[28][50][51][102]
A biochemical mechanism for this was proposed by the medical researcher J. C.
Callaway, who suggested in 1988 that DMT might be connected with visual dream
phenomena: brain DMT levels would be periodically elevated to induce visual
dreaming and possibly other natural states of mind.[103]
A new hypothesis proposed is that in addition to being involved in altered
states of consciousness, endogenous DMT may be involved in the creation of
normal waking states of consciousness. It is proposed that DMT and other
endogenous hallucinogens mediate their neurological abilities by acting as
neurotransmitters at a sub class of the trace amine receptors; a group of
receptors found in the CNS where DMT and other hallucinogens have been shown to
have activity. Wallach further proposes that in this way waking consciousness
can be thought of as a controlled psychedelic experience. It is when the
control of these systems becomes loosened and their behavior no longer
correlates with the external world that the altered states arise.[83]

Dr. Rick Strassman,
while conducting DMT research in the 1990s at the University of
New Mexico, advanced the
controversial hypothesis that a massive release of DMT from the pineal gland
prior to death or near death was the cause of the near death
experience (NDE) phenomenon. Several
of his test subjects reported NDE-like audio or visual hallucinations. His explanation
for this was the possible lack of panic involved in the clinical setting and
possible dosage differences between those administered and those encountered in
actual NDE cases. Several subjects also reported contact with 'other beings',
alien like, insectoid or reptilian in nature, in highly advanced technological
environments[13]
where the subjects were 'carried,' 'probed,' 'tested,' 'manipulated,'
'dismembered,' 'taught,' 'loved,' and even 'raped' by these 'beings.' Basing
his reasoning on his belief that all the enzymatic material needed to produce
DMT is found in the pineal gland (see evidence in mammals), and moreover in substantially greater concentrations than in any
other part of the body, Strassman ([13]
p. 69)argues that DMT is made in the pineal gland.
Currently there is no published reliable scientific evidence supporting this
hypothesis.

In the 1950s, the endogenous production of
psychoactive agents was considered to be a potential explanation for the
hallucinatory symptoms of some psychiatric diseases as the transmethylation
hypothesis[104]
(see also adrenochrome), though this hypothesis does not account for the
natural presence of endogenous DMT in otherwise normal humans, rats and other
laboratory animals.

When ingested, DMT acts as a psychedelic drug.[7] Depending on the dose
and method of administration,
its subjective effects can range from short-lived milder psychedelic states to powerful immersive experiences; these are often described as a total
loss of connection to conventional reality with the encounter of ineffable spiritual/alien realms.[8] Indigenous Amazonian Amerindian cultures consume DMT as the primary psychoactive in ayahuasca, vine used for cureing purposes. Pharmacologically, ayahuasca
combines DMT with an MAOI, an enzyme inhibitor
that allows DMT to be orally active.[9]

Speakmeme indians use it too.

In humans, we can find it in the pineal gland.There is hear and say evidence (rumours) this can help you heal fast from any psychological trauma. For Michelle's boyfriend, the vine made him vomit by his nose. It can screw up your brain, she says.