Chen Chong performed alongside Tang Guoqiang in Zhang Zheng's (Chinese: 张铮) Little Flower (Chinese: 小花; pinyin: Xiǎo Huā) in 1979, for which she won the Hundred Flowers Award (Chinese: 百花奖; pinyin: Bǎi Huā Jiǎng). Chen portrayed a pre-Maoist revolutionary's daughter, who, reunited with her brother, a wounded Communist soldier, later learned that his doctor was her biological mother. Little Flower was her second film and she soon achieved the status of China's most loved actress; she was dubbed "the Elizabeth Taylor of China" by Time magazine for having achieved stardom while still a teenager.[2]

In addition, Chen was in the 1979 film Hearts for the Motherland (Chinese: 海外赤子; pinyin: Hǎiwài Chìzǐ). The film directed by Ou Fan (Chinese: 欧凡) and Xing Jitian (Chinese: 邢吉田) depicts an overseas Chinese family that returns to China from southeast Asia out of their patriotic feelings but encounter political troubles during the Cultural Revolution. The songs, "I Love You, China" (Chinese: 我爱你中国) and "High Flies the Petrel" (Chinese: 高飞的海燕), sung by Chen's character, are perennial favorites in China. In 1981, Chen starred in Awakening (Chinese: 甦醒; pinyin: Sūxǐng), directed by Teng Wenji (Chinese: 滕文骥).

In the middle of the 2000s, Chen made a comeback in acting and began to work intensely, alternating between English and Chinese-language roles.

In 2004, she starred in Hou Yong's family sagaJasmine Women (Chinese: 茉莉花开; pinyin: Mòlìhuā Kāi), alongside Zhang Ziyi, in which they played multiple roles as daughters and mothers across three generations in Shanghai. She also starred in the Asian American comedy Saving Face as a widowed mother, who is shunned by the Chinese-American community for being pregnant and unwed and therefore has come to live with her lesbian daughter.

In 2008, she starred alongside Sam Chow (Chinese: 邹爽) in Shi Qi (Chinese: 十七; pinyin: Shíqī), directed by Joe Chow (Chinese: 姬诚; pinyin: Jī Chéng), as a rural mother of a 17-year-old in eastern Zhejiang province.[6][7] The same year Joan Chen portrayed in Jia Zhangke's 24 City a factory worker once fancied because she resembled Chen herself in the 1979 film Little Flower, but who missed her chance at love.

Chen was formerly married to actor Jimmy Lau from 1985 to 1990. She married her second husband, cardiologist Peter Hui, on January 18, 1992. They have two daughters, Angela and Audrey.[19] They live in San Francisco, California.

In May 2008, Chen appeared alongside James Kyson Lee and Amy Hanaialiʻi Gilliom in a public service announcement for the Banyan Tree Project campaign to stop HIV/AIDS-related stigma in Asian & Pacific Islander communities.[21][22]