Ferrell opened the song with a hilariously lengthy mic check, teasing that he wanted to bring a “local, homegrown kid” – which turned out to be Vedder – onstage. The Pearl Jam frontman played a tambourine, while the comedian wandered around with his trademark cowbell. Smith, Ferrell’s dopplegänger, aggressively bashed his drum set, and Carlile added a rootsy, vocal twang to the 1989 synth-rock track.

Red Hot Chili Peppers guitarist Josh Klinghoffer also performed throughout the night, along with Carlile’s bandmates Tim and Phil Hanseroth. The Cancer for College benefit raised over $300,000, The Seattle Times reports.