Series is based on what Maria has accepted to be "her life." The occasionally surreal episodes, refracted across multiple periods of the actor/comedian's life, tell the story of a woman who loses - and then finds - herself.

Wyatt Bernstein is a typical boy who enjoys hanging out at the local arcade with his friend Pesto. In a household full of females, Wyatt desperately wishes for a brother he could do fun guy stuff with and who would provide him much needed male reinforcement at home.

Ed Stevens is a contracts lawyer at a high-profile New York City firm. Around the same time he splits with his wife (she slept with a mailman), he makes a single error in punctuation when going over a contract; and because of the resulting financial loss to the firm, he's fired.

Stepping into the late-late slot vacated by David Letterman, Conan O'Brien stars in a show that far outdoes its competition in sheer strangeness. Along with the celebrity interviews and musical numbers typical of late-night talk shows, this program make frequent use of odd walk-on characters and frequent "visits" from celebrity guests.