Use the mixing container to mix the contents of the Dose 1 pouch with at least 16 ounces of water by shaking or using a spoon until it’s completely dissolved. This may take up to 2 to 3 minutes. Take your time—slowly drink and finish the dose within 30 minutes.

Refill the container with at least 16 ounces of clear liquid. Again, take your time and slowly finish all of it within 30 minutes. Continue to drink additional clear liquids between the 2 doses.

Wait at least 2 hours from the start of Dose 1, then…

Take Dose 2:

Use the mixing container to mix the contents of Dose 2 (Pouch A and Pouch B) with at least 16 ounces of water by shaking or using a spoon until it’s completely dissolved. This may take up to 2 to 3 minutes. Take your time—slowly drink and finish the dose within 30 minutes.

Refill the container with at least 16 ounces of clear liquid. Again, take your time and slowly finish all of it within 30 minutes. Continue to drink additional clear liquids, but be sure to stop drinking liquids at least 2 hours before your colonoscopy or as recommended by your healthcare provider.

Use the mixing container to mix the contents of the Dose 1 pouch with at least 16 ounces of water by shaking or using a spoon until it’s completely dissolved. This may take up to 2 to 3 minutes. Take your time—slowly drink and finish the dose within 30 minutes.

Refill the container with at least 16 ounces of clear liquid. Again, take your time and slowly finish all of it within 30 minutes. Continue to drink additional clear liquids throughout the evening.

Wait approximately 12 hours from the start of Dose 1, then…

Take Dose 2:

Use the mixing container to mix the contents of Dose 2 (Pouch A and Pouch B) with at least 16 ounces of water by shaking or using a spoon until it's completely dissolved. This may take up to 2 to 3 minutes. Take your time—slowly drink and finish the dose within 30 minutes.

Refill the container with at least 16 ounces of clear liquid. Again, take your time and slowly finish all of it within 30 minutes. Continue to drink additional clear liquids, but be sure to stop drinking liquids at least 2 hours before your colonoscopy or as recommended by your healthcare provider.

Use the mixing container to mix the contents of the Dose 1 pouch with at least 16 ounces of water by shaking or using a spoon until it’s completely dissolved. This may take up to 2 to 3 minutes. Take your time—slowly drink and finish the dose within 30 minutes.

Refill the container with at least 16 ounces of clear liquid. Again, take your time and slowly finish all of it within 30 minutes. Continue to drink additional clear liquids between the 2 doses.

Wait at least 2 hours from the start of Dose 1, then…

Take Dose 2:

Use the mixing container to mix the contents of Dose 2 (Pouch A and Pouch B) with at least 16 ounces of water by shaking or using a spoon until it’s completely dissolved. This may take up to 2 to 3 minutes. Take your time—slowly drink and finish the dose within 30 minutes.

Refill the container with at least 16 ounces of clear liquid. Again, take your time and slowly finish all of it within 30 minutes. Continue to drink additional clear liquids, but be sure to stop drinking liquids at least 2 hours before your colonoscopy or as recommended by your healthcare provider.

Use the mixing container to mix the contents of the Dose 1 pouch with at least 16 ounces of water by shaking or using a spoon until it’s completely dissolved. This may take up to 2 to 3 minutes. Take your time—slowly drink and finish the dose within 30 minutes.

Refill the container with at least 16 ounces of clear liquid. Again, take your time and slowly finish all of it within 30 minutes. Continue to drink additional clear liquids throughout the evening.

Wait approximately 12 hours from the start of Dose 1, then…

Take Dose 2:

Use the mixing container to mix the contents of Dose 2 (Pouch A and Pouch B) with at least 16 ounces of water by shaking or using a spoon until it's completely dissolved. This may take up to 2 to 3 minutes. Take your time—slowly drink and finish the dose within 30 minutes.

Refill the container with at least 16 ounces of clear liquid. Again, take your time and slowly finish all of it within 30 minutes. Continue to drink additional clear liquids, but be sure to stop drinking liquids at least 2 hours before your colonoscopy or as recommended by your healthcare provider.

Do not take PLENVU if you have a blockage in your intestine (bowel obstruction), an opening in the wall of your stomach or intestine (bowel perforation), problems with food or fluid emptying from your stomach (gastric retention), a problem with food moving too slowly through your intestines (ileus), a very dilated large intestine, or an allergy to any of the ingredients in PLENVU.

Watch how to take PLENVU

Same-Day Morning-of-Colonoscopy Dosing* Instruction Video

2-Day Split-Dosing Instruction Video

*

The "One-Day Morning Dosing Regimen" (as it is labeled in the Prescribing Information) is referred to as "Same-Day Morning-of-Colonoscopy Dosing."

Would you like text message reminders and other helpful tips? Text PLENVU to 84883.†Need to know more? Call the toll-free PLENVU hotline at 1-855-MY-PLENVU for 24-hour multilingual assistance Sunday, 4 PM to Friday, 8 PM EST

*

The “One-Day Morning Dosing Regimen” (as it is labeled in the Prescribing Information) is referred to as “Same-Day Morning-of-Colonoscopy Dosing.”

†

At no cost with an unlimited texting plan; otherwise, message and data rates may apply. Message frequency determined by user. Text HELP to 84883 for help. Text STOP to 84883 to cancel. For terms, visit cs1.me/plenvu.

Restrictions apply. Not available to patients enrolled in federal, state, or governmental health care programs, including, but not limited to, Medicare, TRICARE, Veterans Administration, Department of Defense, CHAMPUS, the Puerto Rico Government Health Insurance Plan, or any other federal or state health care program.

PLENVU FAQs

1. What is PLENVU?

PLENVU is a prescription medicine used by adults to clean the colon before a colonoscopy. PLENVU cleans your colon by causing you to have diarrhea (loose stools). Cleaning your colon helps your healthcare provider see the inside of your colon more clearly during your colonoscopy. It is not known if PLENVU is safe and effective in children.

2. What can I expect with PLENVU?

As with any bowel prep, you will experience watery diarrhea. That means PLENVU is working. The cleaner your colon is, the better view your healthcare provider will have during your colonoscopy. You may expect your first bowel movement 1 to 2 hours after taking Dose 1 of PLENVU. You may feel some bloating or stomach discomfort. If you have severe stomach discomfort or bloating, stop drinking PLENVU for a short time or wait a longer time between each dose until your symptoms improve. You will have a few more bowel movements as you take PLENVU, so make sure you’re near a bathroom.

3.

What are the most common side effects of PLENVU?

The most common side effects include nausea, vomiting, dehydration, and stomach pain or discomfort.

4. How do I take PLENVU?

There are 2 different ways to take PLENVU: same-day morning-of-colonoscopy dosing* and 2-day split-dosing. Please contact your healthcare provider's office if you’re not sure which way to take it. Each schedule has 2 doses. You’ll need to take both doses to complete your prep.

Take Dose 1 (mango flavor)

Use the mixing container to mix the contents of the Dose 1 pouch with at least 16 ounces of water by shaking or using a spoon until it's completely dissolved. This may take up to 2 to 3 minutes. Take your time—slowly drink and finish the dose within 30 minutes.

Refill the container with at least 16 ounces of clear liquid. Again, take your time and slowly finish all of it within 30 minutes. Continue to drink additional clear liquids between the 2 doses.

Before Starting Dose 2:
For the same-day morning-of-colonoscopy schedule, WAIT AT LEAST 2 HOURS from the start of Dose 1. For the 2-day schedule, WAIT APPROXIMATELY 12 HOURS from the start of Dose 1.

Take Dose 2 (fruit punch flavor)

Use the mixing container to mix the contents of Dose 2 (Pouch A and Pouch B) with at least 16 ounces of water by shaking or using a spoon until it’s completely dissolved. This may take up to 2 to 3 minutes. Take your time—slowly drink and finish the dose within 30 minutes.

Refill the container with at least 16 ounces of clear liquid. Again, take your time and slowly finish all of it within 30 minutes.

You should drink additional clear liquids of your choice throughout the bowel prep process to stay hydrated and avoid dehydration (fluid loss).

With both dosing schedules (same-day morning-of-colonoscopy or 2-day), you'll need to stop drinking clear liquids at least 2 hours before your colonoscopy or as recommended by your healthcare provider.

*

The “One-Day Morning Dosing Regimen” (as it is labeled in the Prescribing Information) is referred to as “Same-Day Morning-of-Colonoscopy Dosing.”

5. What can I drink with PLENVU?

It’s important to stay hydrated before, during, and after taking PLENVU to help prevent fluid loss (dehydration). You don’t need to drink only water—you can have your choice of clear liquids. Remember: these are liquids you can drink in addition to your PLENVU bowel prep. These are not liquids you can use to mix with PLENVU.

Would you like text message reminders and other helpful tips? Text PLENVU to 84883.* Need to know more? Call the toll-free PLENVU hotline at 1-855-MY-PLENVU with any questions or concerns you may have throughout your prep process (multilingual assistance Sunday, 4 PM to Friday, 8 PM EST)

*

At no cost with an unlimited texting plan; otherwise, message and data rates may apply. Message frequency determined by user. Text HELP to 84883 for help. Text STOP to 84883 to cancel. For terms, visit cs1.me/plenvu.

SEE MORE

INDICATION

PLENVU® (polyethylene glycol 3350, sodium ascorbate, sodium sulfate, ascorbic acid, sodium chloride, and potassium chloride for oral solution) is a prescription medication used by adults to clean the colon before a colonoscopy.

IMPORTANT SAFETY INFORMATION

Do not take PLENVU if you have a blockage in your intestine (bowel obstruction), an opening in the wall of your stomach or intestine (bowel perforation), problems with food or fluid emptying from your stomach (gastric retention), a problem with food moving too slowly through your intestines (ileus), a very dilated large intestine, or an allergy to any of the ingredients in PLENVU.

It is important to drink sufficient clear liquids before, during, and after the use of PLENVU. Be sure to consume additional clear liquids after the first dose and second dose of PLENVU. Stop drinking liquids 2 hours prior to colonoscopy.

Before you take PLENVU, talk to your doctor if you:

Have problems with serious loss of body fluid (dehydration) and changes in blood salts (electrolytes).

Have heart problems or take medication that affects your heart. Your doctor may consider obtaining an electrocardiogram (ECG) test if you are at an increased risk for heart rhythm abnormalities.

Have a history of seizures or take antiseizure medication.

Have kidney problems or take medication that affects kidney function. Your doctor may want to perform blood testing before and after your colonoscopy.

Have a history of stomach or bowel problems, such as ulcerative colitis, a bowel blockage, or a suspected opening in the wall of your stomach or intestine.

Have problems swallowing, heartburn (gastric reflux), or if you inhale food or fluid into your lungs when eating or drinking (aspirate).

Have a condition that destroys red blood cells, called glucose-6-phosphate dehydrogenase (G6PD) deficiency.

PLENVU may affect how other medications work. Tell your doctor about all other medications (including prescription and nonprescription medicines, vitamins, and herbal supplements) you take before you take PLENVU. Do not take oral medications within 1 hour before or after starting each dose of PLENVU.

The health information contained herein is provided for educational purposes only and is not intended to replace discussions with a healthcare provider. All decisions regarding patient care must be made with a healthcare provider, considering the unique characteristics of the patient.

The product information provided in this site is intended only for residents of the United States. The products discussed herein may have different product labeling in different countries.

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PLENVU is a registered trademark of the Norgine group of companies used under license. The Salix logo and "Little PEG" female character are trademarks of Salix Pharmaceuticals affiliated entities. Any other product/brand names and/or logos are trademarks of their respective owners.