Weitere ELISA Kits für CYP11A1 Interaktionspartner

Active Site Structures of CYP11A1 in the Presence of Its Physiological Substrates and Alterations upon Binding of Adrenodoxin

The present study systematically evaluated the genetic effect of the estrogen metabolic pathway on alzheimer's based on 78 polymorphisms distributed across four genes. In the southern Chinese population, strong evidence of associations with AD were detected for polymorphisms in ESR2 (zeige ESR2 ELISA Kits) and CYP11A1.

The findings of this study provided further support for the hypothesis that a susceptibility gene for autism spectrum disorder exists within or near the CYP11A1 gene in the Han Chinese population.

These findings contribute in clarifying the relationship between hormones regulating the early phase of steroidogenesis confirming that AMH (zeige AMH ELISA Kits) is playing a suppressive role on CYP19A1 (zeige CYP19A1 ELISA Kits) expression stimulated by gonadotropin in hGCs. Furthermore, a similar inhibitory effect for AMH (zeige AMH ELISA Kits) was observed on P450scc gene expression when activated by gonadotropin treatment.

Data show that a deletion of 20 amino acids comprising parts of the F-G loop results in an enzyme with a three-fold increased solubility, the highest solubility of a CYP11A1 variant obtained so far.

kinetic analysis of CYP11A1

Results describe the association of vitamin D3 with phospholipid vesicles and determine the kinetics of metabolism of vitamin D3 by P450scc in vesicles and in 2-hydroxypropyl-beta-cyclodextrin (cyclodextrin).

Data suggest that gonadotropin-induced accumulation of P450scc mRNA results from increased transcription, and that this stimulation, at least in part, is protein synthesis-dependent.

Testicular expression of CYP11A1 is not solely responsible for the QTL influencing boar fat androstenone levels.

Under hypoxia reoxygenation or ischemia and reperfusion, StAR and CYP11A1 protein and gene expression was reduced without apparent relation to TSPO changes.

CYP11A1 Antigen-Profil

Beschreibung des Gens

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane and catalyzes the conversion of cholesterol to pregnenolone, the first and rate-limiting step in the synthesis of the steroid hormones. Two transcript variants encoding different isoforms have been found for this gene. The cellular location of the smaller isoform is unclear since it lacks the mitochondrial-targeting transit peptide.