Figure 4.

OARSI histopathology grading and staging scores. OARSI histopathology grading and
staging scores were determined in sham (control), and contralateral and ipsilateral
treatments of both NM and FM groups of animals over 20 weeks. Tibial joint surfaces
from (a) sham and (b) contralateral and ipsilateral treatments were assessed independently of femoral (c) sham and (d) contralateral and ipsilateral joint surfaces. Mean OARSI scores ± standard error are
shown. Significantly higher scores were observed in NM contralateral femurs than NM
sham femurs at 2 and 12 weeks (statistics not shown). Both ipsilateral surfaces had
significantly higher OARSI scores than shams at all time points, except NM ipsilateral
surfaces at 2 weeks (statistics not shown). Statistical analysis is done for each
individual time point to indicate significantly different means among each of the
four contralateral and ipsilateral treatments. Similar means at each time point are
indicated by the same letter (a, b, and c), whereas significantly different means
at each time point are indicated by different letters (P < 0.05; n = 4). FM, forced mobilization; NM, nonmobilized; OARSI, Osteoarthritis Research Society
International.