Let $G$ be an at most countable discrete group acting freely on a standard probability measure space $X$ in a measure preserving way.

It is well known that if $G$ is a finite group then this action admits a fundamental domain. As pointed out by Andreas below, by Rokhlin lemma, if $G$ contains an element of infinite order we can find an $(\varepsilon, N)$-fundamentalish domain $U$, where the latter is defined as follows:

Call a set $U\subset X$ an $(\varepsilon, N)$-fundamentalish domain iff there exist $N$ elements $g_1, \ldots, g_N$ of $G$ such that the sets $g_i(U)$ are pairwise disjoint and the measure of their union is at least $1-\varepsilon$.

Question: If $G$ is an infinite group, $N_0$ is a natural number, $\varepsilon_0$ is a positive real number, does there exist an $(\varepsilon, N)$-fundamentalish domain with $\varepsilon<\varepsilon_0$ and $N>N_0$?

For example when the action is profinite and "transitive on each level", then clearly answer is positive: there exist $(0,N)$-fundamentalish domains for arbitrary large $N$.

Let $G$ be a countable group acting freely and measure preservingly on a standard probability space $(X, \mu)$. Fix a finite set $T \subseteq G$. If for every $\epsilon > 0$ there is a measurable set $U \subseteq X$ such that the $T$-translates of $U$ are disjoint and $\mu(T \cdot U) > 1 - \epsilon$, then $T$ tiles $G$ in the sense that there is a set of centers $C \subseteq G$ such that the sets $Tc$ ($c \in C$) partition $G$.

They also prove that if $G$ is amenable then the converse holds. So if $G$ is amenable and $T$ is a tile for $G$, then for every free probability measure preserving action of $G$ and every $\epsilon > 0$ there is a $(\epsilon, |T|)$-fundamentalish domain. Thus a natural question is: which amenable groups admit arbitrarily large finite tiles?

Weiss called a group $G$ MT (mono-tileable) if for every finite set $F \subseteq G$ there is a finite tile $T \subseteq G$ containing $F$. In "Monotileable amenable groups," Weiss proved that all solvable groups and all residually finite groups are MT. In "Elementary Amenable Groups," Chou proved that all elementary amenable groups and all free products of non-trivial groups are MT. So in particular, your question has a positive answer whenever the group $G$ is elementary amenable. A stronger tiling condition, called ccc, is studied in chapter 4 of "Groups Colorings and Bernoulli Subflows" (this paper is in preparation). Weaker properties of poly-MT and poly-ccc are studied in "Burnside's Problem, spanning trees, and tilings." To the best of my knowledge these are the only papers which study tilings of countable groups.