Download AlignmentWe filter this alignment to remove positions that have > 75% gaps before running GREMLIN.

Length:

279 (252)

Sequences:

1854 (1200.1)

Seq/Len:

7.357

Nf(neff/√len):

75.6

HHblits Results: (2016_02)
Sequences per length for each position, BEFORE the coverage/gap filter was appliedLegend: Dots above the red line, indicates positions where there is > 5 sequences per length (if visible, green bar = 20 seq/len). Point of this graphic is to give you an idea if resubmitting a sub-portion of your sequence might help increase the overall Seq/Len (which after applying the coverage filter is at: 7.357).

Sequences per length for each position, AFTER the coverage/gap filter was appliedLegend: If visible, the positions blocked in grey are regions that have > 75% gaps and were automatically trimmed and excluded in the GREMLIN analysis.

Trim query

Generate MSA using:

Filter MSA

GREMLIN

Start:

End:

E-value:

Iterations:

Coverage:

Remove gaps:

Prior:

GREMLIN Results:
Residue pairs sorted by coevolution strength:Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] covarying residues with sequence seperation > 3. The i and j are positions as given in the input sequence.