POSITION
I am an emeritus professor in Biochemistry at the University of Amsterdam (retired 2010).

RESEARCH
My research focussed on the human chromatin in its natural environment, i.e. the nucleus of cultured living human cells.
Aspects, such as the dynamic folding of the chromatin fiber inside the nucleus and local chemical modification of histones and DNA at genetic loci, are the physical and chemical basis for epigenetic regulation of gene expression. In my group we worked parallel on human
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I am a postdoc in The University of Tokyo. My research interest is to know structure of biological systems by functional relationships between genes working in response to endogenous and/or exogenous disruptions. I'm trying to find functional relationships between genes by similarity of phenotype defined with high-dimensional morphological features in yeast gene deletion collection. I'm happy if you will talk with me in any topics.

Optimisation of Bacillus subtilis for the secretion of heterologous proteins Therapeutic proteins (including those required for experimental purposes and clinical trials) are major products of biomanufacturing processes and considerable time and expense are expended to maximise the yield and quality of proteins produced in heterologous hosts. The production host of choice is the Gram-negative bacterium Escherichia coli for which many strains and expression systems have been developed. However,
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