Gladstone Core Services

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The Transgenic Gene-Targeting Core has been an integral part of the Gladstone Institutes UCSF research community for more than 20 years, producing essential mouse models as a service to Investigators at the Gladstone Institutes, UCSF, and other research institutions.

New! CRISPR-mediated knock-out and knock-in services are now available.

We work with the UCSF ES Cell Targeting Core to provide a full-range of gene knock-out and knock-in services. Please contact http://escore.ucsf.edu/ for custom TALEN/CRISPR and ES cell targeting services.

Transgenic and knockout technologies enable investigators to learn how specific genes and proteins, or their variants, function in a natural living animal environment with a defined genetic background in ways not possible by other experimental approaches. At the Gladstone Institutes transgenic mouse models have been used to understand how specific genes affect atherosclerosis, Alzheimer's disease, obesity, AIDS, and other diseases and disorders that impact modern life.