Abstract

Active targeted drug delivery occurs when a drug is associated with a biodegradable polymer and a bio-targeting compound and administered to the site of interest. In this study, these nanocomposite spheres are characterized using various techniques. In-vitro characterization of the nano-spheres containing therapeutic agent and fluorescence molecules are accomplished by culturing live cells in microscopic cells, and introducing the nano-spheres. In-vivo studies are conducted using immune-deficient mice. Other characteristics such as release rates, percent entrapment efficiency and size are studied with UV-Vis spectroscopy, TGA, and TEM.

Description

First Place winner of poster presentations at the 6th Annual Symposium on Graduate Research and Scholarly Projects (GRASP) held at the Hughes Metropolitan Complex, Wichita State University, April 23, 2010.

Research completed at the Department of Mechanical Engineering, College of Engineering