My rheumatologist would say yes, it's an allergic reaction, don't take that medication again. Many doctors would say no, it's a histamine reaction, take some benadryl next time. My rheumatologist errs on the side of caution, which is mostly fine with me. I couldn't tolerate the itchiness I get with Hydrocodone anyhow. He may in my case have actually been correct, since another related opioid later gave me itchiness, hives and shortness of breath.

When I had major itchiness over my whole body after taking antibiotics, I was told it was an allergy, and to never take that medicine again.

When I experienced severe itchiness on mostly my legs when I took narcotic pain meds, I was told it was a side effect. The side effect faded away after a few days, and I haven't had much problem with that since.

But everyone is different. I would talk to your doctor, or even a good pharmacist. Good luck!

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Psoriatic spondylitis, became severe within 3 years; on disability. Single, age 57. Failed Humira, Remicade, and methotrexate. Can't take NSAIDS or opioid pain meds. Also have adrenal insufficiency and thyroid issues.

Narcotics, such as Percocet, can make you itchy and it is not necessarily an allergic reaction. If it is associated with a rash or hives, then YES, it is an allergic reaction. Otherwise it is typically a common, harmless, but very annoying side affect. I take Oxycodone and it makes me itchy as well. I take Benadryl with it, and that helps with the itching.

No, itching is a common opioid side effect, not an allergic reaction. As Kim said, if you are having other symptoms on your skin or elsewhere (e.g. trouble breathing) then that should be more concerning.

From drugs.com -

Seek medical attention right away if any of these SEVERE side effects occur when using Percocet:

Serious adverse reactions that may be associated with Percocet tablet use include respiratory depression, apnea, respiratory arrest, circulatory depression, hypotension, and shock.

The most frequently observed non-serious adverse reactions include lightheadedness, dizziness, drowsiness or sedation, nausea, and vomiting. These effects seem to be more prominent in ambulatory than in nonambulatory patients, and some of these adverse reactions may be alleviated if the patient lies down. Other adverse reactions include euphoria, dysphoria, constipation, and pruritus [itching]. (emphasis mine)

Narcotics, such as Percocet, can make you itchy and it is not necessarily an allergic reaction. If it is associated with a rash or hives, then YES, it is an allergic reaction. Otherwise it is typically a common, harmless, but very annoying side affect. I take Oxycodone and it makes me itchy as well. I take Benadryl with it, and that helps with the itching.

Funny, exactly what my Dr. said to do! Now that I'm in a cast it feels somewhat better, but not really (if that makes any sense).

Thanks for the replies, I just did NOT want to end up in the ER with another anaphylactic reaction!!

hi, everyone, i am curious as to the use of suboxone? And also I had a interaction last week that scared me bad. I have DDD, Sciatica, 2 hip replacements, AS and more.....I decided to go to a Hospital for suboxone treatment.HE@@ story. I was put on a heating pad for 23 hours non-stop! Is that not dangerous?