Welcome to the Laboratory of Structure Guided Drug Discovery

Through collaborations with DFCI and Longwood area laboratories, our lab helps solve chemical and structural biology problems in the field of cancer research. We perform and contribute to mechanism of action studies and structural biology by generating high quality proteins and executing biophysical characterization experiments, binding kinetic and thermodynamic analyses, assay development, and fragment-based or compound library screening. Notably, we conduct X-ray crystallography for use in a wide variety of studies including structure-guided drug discovery.