Set in the Shinigami technical school for weapon meisters, the series revolves around 3 groups of each a weapon meister and a human weapon. Trying to make the latter a "Death Scythe" and thus fit for use by the Shinigami, they must collect the souls of 99 evil humans and 1 witch.

Soul Eater is an anime that centers around meisters and their weapons and their mission to collect 99 evil souls and 1 witch soul. Upon doing that the meister's weapons will become a Deathscythe, which is the highest title for a weapon. Maka, Soul Eater, Black Star, Tsubaki, Death the Kid, and Patty and Liz Thompson are the characters Soul Eater revolves around. Besides taking the time to gather souls these students of Shibusen defend Death City from some of the most powerful of creatures while still attending school and trying to become stronger.