This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

Alternative names

HD 7

HD 7B

HD 9

HD7

HD7B

HD9

HDAC

HDAC 7

HDAC 7B

HDAC 9

HDAC 9B

HDAC 9FL

HDAC7

HDAC7B

HDAC9

HDAC9_HUMAN

HDAC9B

HDAC9FL

HDRP

Histone deacetylase 4/5 related protein

Histone deacetylase 7

Histone deacetylase 7B

Histone deacetylase 9

Histone deacetylase 9A

Histone deacetylase related protein

Histone deacetylase-related protein

KIAA0744

MEF2 interacting transcription repressor MITR

MEF2 interacting transcription repressor protein

MEF2-interacting transcription repressor MITR

MITR

see all

FunctionResponsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Represses MEF2-dependent transcription.Isoform 3 lacks active site residues and therefore is catalytically inactive. Represses MEF2-dependent transcription by recruiting HDAC1 and/or HDAC3. Seems to inhibit skeletal myogenesis and to be involved in heart development. Protects neurons from apoptosis, both by inhibiting JUN phosphorylation by MAPK10 and by repressing JUN transcription via HDAC1 recruitment to JUN promoter.