On behalf of Morgan Stanley Institutional Fund, Inc. (Registrant), we hereby submit for filing pursuant to Rule 497(e) under the Securities Act of 1933, as amended, exhibits containing interactive data format risk/return summary information for the Registrant. These exhibits contain the risk/return summary information in the prospectuses for the Registrant dated April 30, 2012. The purpose of this filing is to submit the XBRL information from the 497(e) filing dated January 14, 2013 for the Registrant.

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