vitamin C is metabolized into Hydrogen Perox

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crystal sage 241

Cancer has an affinity to vitamin C because a vitamin C molecule is very close to a glucose molecule, and we all should know that cancer has an affinity to glucose.

Linus Pauling, two time Nobel Lauriat, theorized that if we could get enough vitamin C into the blood, that the peroxidization (vitamin C is metabolized into Hydrogen Peroxide) would be great enough to kill cancer cells.

C.Y. Lee, Cornell professor of food science and technology, and his South Korean colleagues, Ki Won Lee, Hyong Joo Lee and Kyung-Sun Kang, found that vitamin C blocks the carcinogenic effects of hydrogen peroxide on intercellular communication. Until this finding, the mechanism for vitamin C's inhibitory effects on carcinogenic tumor formation was not understood.

However, the report notes that quercetin, a phytochemical found in apples, has even stronger anticancer activity than vitamin C. (Phytochemicals, such as flavanoids and polyphenols, are plant chemicals that contain protective, disease-preventing compounds.)

Although vitamin C protects against oxidative DNA damage through its free-radical scavenging activity, Lee and his coworkers believe that the vitamin's anti-tumor action functions through a different mechanism.

"The most powerful weapon we have in the Þght against cancer is prevention," concludes Lee. "A diet rich in phytochemicals and vitamin C will reduce the risk of cancer. These phytochemicals and nutrients are most readily available in fresh fruits and vegetables." These recommendations echo those of Lee and his Cornell colleagues in a report in the journalNature (June 22, 2000).

Hydrogen peroxide, the same mild acid that many people use to disinfectant their kitchens or treat cuts and abrasions, is also produced by the body to keep cells healthy.

Now, researchers at Wake Forest University School of Medicine have solved how part of this complex process works.

Reporting in the January 3 issue of Nature, a team led by W. Todd Lowther, Ph.D., developed a three-dimensional snapshot of how two proteins produced by cells interact to regulate the levels of hydrogen peroxide.

For example, when the immune system is activated in response to bacteria, large amounts of hydrogen peroxide are produced by certain cells to fight the infection. Lowther and colleagues studied how a molecule known as peroxiredoxin (Prx) helps control levels of the agent. The role of Prx is important because if the levels of hydrogen peroxide become too high, the cell's DNA and other proteins can be damaged. Scientists suspect that this and similar processes are what leads to cancer, diabetes and other disease.

Prx actually has a dual role in the process. Its usual job is removing excess hydrogen peroxide from the cells by converting it to water. But if levels get dangerously high - and Prx needs help - it becomes inactive in its "converting" job and instead becomes a "signaler," telling the cell to produce or activate other proteins to help remove the excess.

"It basically acts as a sensor and warns the cell that levels are too high and that the cell needs to respond," said Thomas J. Jönsson,

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Alladar 1

Ectoplasmic Residue

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“Due to the lack of experienced trumpeters, the end of the world has been postponed for three weeks”

There has been major breakthrough in cancer treatment research, sources confirm. Research scientists at the University of Otago School Of Medicine say that including Vitamin C in your daily diet could reduce the risk of cancer; in fact, it could also help fight cancer. This link between Vitamin C and cancer treatment, if true, could actually change the face of medicine in a myriad ways.

The research of these scientists has been published in the highly-esteemed Cancer Research journal, and it indicates that if Vitamin C is introduced to a tumour, it may reduce in size, become less resistant to chemotherapy and bring about a possible cure. It will also slow the rate of growth of the tumour, and the cancer cells will be more likely to respond to chemo treatment.

The research also involves a study that indicates that Vitamin C kills the protein that helps carcinogenic cells to grow. Dr. Visser, a part of the team, confirms that the Vitamin C treatment would apply to most solid cancers, including haematological tumours like leukaemia.

After this research, it is upto to doctors to find various ways to introduce the vitamin to tumours and cancer cells. Also, what is important to know is that Vitamin C is one that is benefits not only cancer patients but also people who just want to keep healthy.

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crystal sage 241

(NaturalNews) A high intake of vitamin C is shown to improve life expectancy by six years. Not only does vitamin C help prevent the diseases that shorten life, but the vitamin itself has life sustaining properties. Vitamin C is known to help prevent heart attacks and strokes. It repairs blood vessels and helps reduce heart disease, which are the leading causes of death in the United States.

The mechanism that is used by vitamin C is via the production of collagen. Vitamin C has the effect of increasing collagen production, and collagen is important in maintaining the cell wall of the circulatory system: veins, arteries and capillaries.

The vast majority of animals and plants are able to synthesize their own vitamin C, through a sequence of four enzyme-driven steps, which convert glucose to vitamin C.[2] The glucose needed to produce ascorbate in the liver (in mammals and perching birds) is extracted from glycogen; ascorbate synthesis is a glycogenolysis-dependent process.[14] In reptiles and birds the biosynthesis is carried out in the kidneys.

Among the animals that have lost the ability to synthesise vitamin C are simians (to be specific, one of two major primate suborders, the anthropoidea, also called haplorrhini, which includes humans), guinea pigs, a number of species of passerine birds (but not all of them—there is some suggestion that the ability was lost separately a number of times in birds), and many (probably all) major families of bats, including major insect and fruit-eating bat families. These animals all lack the L-gulonolactone oxidase (GULO) enzyme, which is required in the last step of vitamin C synthesis, because they have a defective form of the gene for the enzyme (Pseudogene ΨGULO).[15] Some of these species (including humans) are able to make do with the lower levels available from their diets by recycling oxidised vitamin C.[16]

humans) are able to make do with the lower levels available from their diets by recycling oxidised vitamin C

The non-functional gulonolactone oxidase pseudogene (GULOP) was mapped to human chromosome 8p21 that corresponds to an evolutionarily conserved segment on either porcine chromosome 4 (SSC4) or 14 (SSC14).[1][2][3] GULO produces the precursor to ascorbic acid, which spontaneously converts to the vitamin ("vitamin C").

“If hydrogen peroxide formed in the blood or were given directly, either blood will destroy it or if enough hydrogen peroxide is given, hydrogen peroxide will break the red cells and cause havoc to the kidneys,” he says.

When vitamin C is injected, it appears to diffuse outside of the bloodstream, allowing reactions to generate hydrogen peroxide.

“You don’t want hydrogen peroxide in the blood itself,” says Levine. “But if hydrogen peroxide is present outside the blood, there is the potential that it could work as a drug.”

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crystal sage 241

Reporting in the January 3 issue of Nature, a team led by W. Todd Lowther, Ph.D., developed a three-dimensional snapshot of how two proteins produced by cells interact to regulate the levels of hydrogen peroxide.

For example, when the immune system is activated in response to bacteria, large amounts of hydrogen peroxide are produced by certain cells to fight the infection. Lowther and colleagues studied how a molecule known as peroxiredoxin (Prx) helps control levels of the agent. The role of Prx is important because if the levels of hydrogen peroxide become too high, the cell's DNA and other proteins can be damaged. Scientists suspect that this and similar processes are what leads to cancer, diabetes and other disease.

Prx actually has a dual role in the process. Its usual job is removing excess hydrogen peroxide from the cells by converting it to water. But if levels get dangerously high – and Prx needs help – it becomes inactive in its “converting” job and instead becomes a “signaler,” telling the cell to produce or activate other proteins to help remove the excess.

“It basically acts as a sensor and warns the cell that levels are too high and that the cell needs to respond,” said Thomas J. Jönsson, Ph.D., lead author, and a post-doctoral fellow at Wake Forest. “Once that threat is gone, Prx needs to go back to its normal state.”

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crystal sage 241

This original study suggests that a low plasma vitamin C concentration is a risk for spontaneous intracerebral hemorrhages," lead researcher Stephane Vannier, MD, a neurologist at Pontchaillou University Hospital, Rennes, France, told Medscape Medical News.

"This link is probably associated with the role of vitamin C in blood pressure regulation and collagen biosynthesis," although other factors may also play a role, said Dr. Vannier.

These findings, he added, provide the rationale for clinical trials to test the efficacy of vitamin C supplementation in preventing hemorrhagic stroke and minimizing infectious or cutaneous complications in those sustaining an ICH.