Actor Johnny Depp may replace Michael Keaton in the “Beetlejuice” sequel, if it happens.

Following his career revival with “Birdman” and “Spotlight,” Keaton is allegedly reluctant to return for the sequel, reported Digital Spy.

Director Tim Burton has reportedly decided to move on and wishes to cast his regular star Johnny Depp to fill Keaton’s shoes as the “ghost with the most”.

This would mark the latest collaboration between Burton and Depp following the likes of “Edward Scissorhands,” “Charlie and the Chocolate Factory,” “Sweeney Todd,” “Dark Shadows” and “Alice in Wonderland.”

Depp, 52, wants to make Beetlejuice similar to his Guy Lapointe character that he’s played for Kevin Smith in both Tusk and Yoga Hosers, while adding a cockney accent.