Citation Manager

Below are the first 10 and last 10 pages of uncorrected machine-read text (when available) of this chapter, followed by the top 30 algorithmically extracted key phrases from the chapter as a whole.Intended to provide our own search engines and external engines with highly rich, chapter-representative searchable text on the opening pages of each chapter.
Because it is UNCORRECTED material, please consider the following text as a useful but insufficient proxy for the authoritative book pages.

Do not use for reproduction, copying, pasting, or reading; exclusively for search engines.

OCR for page R1
Vaccines for the 21st Century: A Tool for Decisionmaking
Vaccines for the 21st Century
A TOOL FOR DECISIONMAKING
Kathleen R.Stratton, Jane S.Durch, and Robert S.Lawrence, Editors
Committee to Study Priorities for Vaccine Development
Division of Health Promotion and Disease Prevention
INSTITUTE OF MEDICINE
NATIONAL ACADEMY PRESS
Washington, D.C.

OCR for page R1
Vaccines for the 21st Century: A Tool for Decisionmaking
NATIONAL ACADEMY PRESS
2101 Constitution Avenue, N.W. Washington, DC 20418
NOTICE: The project that is the subject of this report was approved by the Governing Board of the National Research Council, whose members are drawn from the councils of the National Academy of Sciences, the National Academy of Engineering, and the Institute of Medicine. The members of the committee responsible for the report were chosen for their special competences and with regard for appropriate balance.
This project has been funded in whole with federal funds from the National Institutes of Allergy and Infectious Diseases, National Institutes of Health, under Contract No. N01-AI-45237. The views presented are those of the Institute of Medicine Committee to Study Priorities for Vaccine Development and are not necessarily those of the funding organization.
Library of Congress Cataloging-in-Publication Data
Institute of Medicine (U.S.). Committee to Study Priorities for Vaccine Development.
Vaccines for the 21st century: a tool for decisionmaking/Kathleen R.Stratton, Jane S.Durch, and Robert S.Lawrence, editors; Committee to Study Priorities for Vaccine Development, Division of Health Promotion and Disease Prevention, Institute of Medicine.
p.; cm.
Includes bibliographical references and index.
ISBN 0-309-05646-2 (hard cover)
1. Vaccines—Research—United States—Planning. I. Stratton, Kathleen R. II. Durch, Jane. III. Lawrence, Robert S., 1938- IV. Title.
[DNLM: 1. Vaccines. 2. Economics, Pharmaceutical. 3. Models, Theoretical. 4. Research. QW 805 I592v 2000]
RA638 .I556 2000
615'.372'072073—dc21
00–025528
Vaccines for the 21st Century: A Tool for Decisionmaking is available for sale from the
National Academy Press,
2101 Constitution Avenue, N.W., Box 285, Washington, DC 20055. Call (800) 624–6242 or (202) 334–3313 (in the Washington metropolitan area), or visit the NAP’s on-line bookstore at www.nap.edu. The full text of this publication is available on line at www.nap.edu.
For more information about the Institute of Medicine, visit the IOM home page at www.iom.edu.
Copyright 2000 by the National Academy of Sciences. All rights reserved.
Printed in the United States of America

OCR for page R1
Vaccines for the 21st Century: A Tool for Decisionmaking
“Knowing is not enough; we must apply.
Willing is not enough; we must do.”
—Goethe
INSTITUTE OF MEDICINE
Shaping the Future for Health

OCR for page R1
Vaccines for the 21st Century: A Tool for Decisionmaking
THE NATIONAL ACADEMIES
National Academy of Sciences
National Academy of Engineering
Institute of Medicine
National Research Council
The National Academy of Sciences is a private, nonprofit, self-perpetuating society of distinguished scholars engaged in scientific and engineering research, dedicated to the furtherance of science and technology and to their use for the general welfare. Upon the authority of the charter granted to it by the Congress in 1863, the Academy has a mandate that requires it to advise the federal government on scientific and technical matters. Dr. Bruce M.Alberts is president of the National Academy of Sciences.
The National Academy of Engineering was established in 1964, under the charter of the National Academy of Sciences, as a parallel organization of outstanding engineers. It is autonomous in its administration and in the selection of its members, sharing with the National Academy of Sciences the responsibility for advising the federal government. The National Academy of Engineering also sponsors engineering programs aimed at meeting national needs, encourages education and research, and recognizes the superior achievements of engineers. Dr. William A.Wulf is president of the National Academy of Engineering.
The Institute of Medicine was established in 1970 by the National Academy of Sciences to secure the services of eminent members of appropriate professions in the examination of policy matters pertaining to the health of the public. The Institute acts under the responsibility given to the National Academy of Sciences by its congressional charter to be an adviser to the federal government and, upon its own initiative, to identify issues of medical care, research, and education. Dr. Kenneth I.Shine is president of the Institute of Medicine.
The National Research Council was organized by the National Academy of Sciences in 1916 to associate the broad community of science and technology with the Academy’s purposes of furthering knowledge and advising the federal government. Functioning in accordance with general policies determined by the Academy, the Council has become the principal operating agency of both the National Academy of Sciences and the National Academy of Engineering in providing services to the government, the public, and the scientific and engineering communities. The Council is administered jointly by both Academies and the Institute of Medicine. Dr. Bruce M.Alberts and Dr. William A.Wulf are chairman and vice chairman, respectively, of the National Research Council.

OCR for page R1
Vaccines for the 21st Century: A Tool for Decisionmaking
COMMITTEE TO STUDY PRIORITIES FOR VACCINE DEVELOPMENT
ROBERT S.LAWRENCE, M.D. (Chair), Associate Dean for Professional Education and Programs and Professor of Health Policy and Management,
Johns Hopkins School of Hygiene and Public Health
CAROL J.BAKER, M.D.,
Texas Children’s Hospital Foundation
Chair and Professor of Pediatrics, Microbiology, and Immunology and
Head,
Section of Infectious Diseases, Baylor College of Medicine
DAN W.BROCK, Ph.D., Charles C.Tillinghast, Jr.,
University Professor of Philosophy and Biomedical Ethics,
Director,
Center for Biomedical Ethics, Brown University
K.LYNN CATES, M.D., Associate Professor of Pediatrics,
Case Western Reserve University School of Medicine
ANNE A.GERSHON, M.D., Professor of Pediatrics,
College of Physicians and Surgeons, Columbia University
PETER M.HOWLEY, M.D., George Fabyan Professor and Chairman,
Department of Pathology, Harvard Medical School
SAMUEL L.KATZ, M.D., Wilburt C.Davison Professor and Chairman Emeritus,
Department of Pediatrics, Duke University Medical Center
JEFFREY KOPLAN, M.D., M.P.H.,* Executive Vice President and Director,
Prudential Center for Health Care Research, Atlanta
F.MARC LaFORCE, M.D., Professor of Medicine,
University of Rochester School of Medicine and Dentistry
JERRY R.McGHEE, Ph.D., Director,
Immunobiology Vaccine Center and
Professor of Microbiology,
University of Alabama at Birmingham
PEARAY L.OGRA, M.D., John Sealy Distinguished Chair and Professor of Pediatrics,
Children’s Hospital, University of Texas Medical Branch at Galveston
JUNE E.OSBORN, M.D., President,
Josiah Macy, Jr. Foundation, New York City
ELI E.SERCARZ, Ph.D., Professor Emeritus,
Department of Microbiology and Molecular Genetics, University of California at Los Angeles, and
Head and Member,
Division of Immune Regulation, La Jolla Institute for Allergy and Immunology, San Diego
MILTON C.WEINSTEIN, Ph.D., Henry J.Kaiser Professor of Health Policy and Management,
Harvard School of Public Health
Staff
KATHLEEN STRATTON, Ph.D., Study Director
JANE DURCH, Program Officer
CYNTHIA HOWE, Program Officer
*
Member until September 1998. He became director of the Centers for Disease Control and Prevention in October 1998.

OCR for page R1
Vaccines for the 21st Century: A Tool for Decisionmaking
Acknowledgments
This report has been reviewed in draft form by individuals chosen for their diverse perspectives and technical expertise, in accordance with procedures approved by the National Research Council’s Report Review Committee. The purpose of this independent review is to provide candid and critical comments that will assist the institution in making the published report as sound as possible and to ensure that the report meets institutional standards for objectivity, evidence, and responsiveness to the study charge. The review comments and draft manuscript remain confidential to protect the integrity of the deliberative process. We wish to thank the following individuals for their participation in the review of this report:
Charles C.J.Carpenter, M.D., Brown University;
Gordon DeFriese, Ph.D., University of North Carolina at Chapel Hill;
Roger D.Feldman, Ph.D., University of Minnesota;
Harvey V.Fineberg, M.D., Ph.D., Harvard University;
Fernando Guerra, M.D., M.P.H., San Antonio Metropolitan Health District;
Michael Katz, M.D., March of Dimes Birth Defects Foundation;
Louis Lasagna, M.D., Tufts University School of Medicine; and
Henry W.Riecken, Ph.D., University of Pennsylvania.
While the individuals listed above have provided constructive comments and suggestions, it must be emphasized that responsibility for the final content of this report rests entirely with the authoring committee and the institution.

OCR for page R1
Vaccines for the 21st Century: A Tool for Decisionmaking
This page in the original is blank.

Bookmark this page

Important Notice

As of 2013, the National Science Education Standards have been replaced by the Next Generation Science Standards (NGSS), available as a print book, free PDF download, and online with our OpenBook platform.