1. "I urge you to please notice when you are happy, and exclaim or murmur or think at some point, 'If this isn't nice, I don't know what is.'"

The actual advice here is technically a quote from Kurt Vonnegut's "good uncle" Alex, but Vonnegut was nice enough to pass it on at speeches and in A Man Without A Country. Though he was sometimes derided as too gloomy and cynical, Vonnegut's most resonant messages have always been hopeful in the face of almost-certain doom. And his best advice seems almost ridiculously simple: Give your own happiness a bit of brainspace.

2. "Peculiar travel suggestions are dancing lessons from God."

In Cat's Cradle, the narrator haplessly stumbles across the cynical, cultish figure Bokonon, who populates his religious writings with moronic, twee aphorisms. The great joke of Bokononism is that it forces meaning on what's essentially chaos, and Bokonon himself admits that his writings are lies. If the protagonist's trip to the island nation of San Lorenzo has any cosmic purpose, it's to catalyze a massive tragedy, but the experience makes him a devout Bokononist. It's a religion for people who believe religions are absurd, and an ideal one for Vonnegut-style humanists.

Another koan of sorts from Cat's Cradle and the Bokononist religion (which phrases many of its teachings as calypsos, as part of its absurdist bent), this piece of doggerel is simple and catchy, but it unpacks into a resonant, meaningful philosophy that reads as sympathetic to humanity, albeit from a removed, humoring, alien viewpoint. Man's just another animal, it implies, with his own peculiar instincts, and his own way of shutting them down. This is horrifically cynical when considered closely: If people deciding they understand the world is just another instinct, then enlightenment is little more than a pit-stop between insoluble questions, a necessary but ultimately meaningless way of taking a sanity break. At the same time, there's a kindness to Bokonon's belief that this is all inevitable and just part of being a person. Life is frustrating and full of pitfalls and dead ends, but everybody's gotta do it.

4. "There's only one rule that I know of, babies—God damn it, you've got to be kind."

This line from God Bless You, Mr. Rosewater comes as part of a baptismal speech the protagonist says he's planning for his neighbors' twins: "Hello, babies. Welcome to Earth. It's hot in the summer and cold in the winter. It's round and wet and crowded. At the outside, babies, you've got about a hundred years here. There's only one rule that I know of, babies—God damn it, you've got to be kind." It's an odd speech to make over a couple of infants, but it's playful, sweet, yet keenly precise in its summation of everything a new addition to the planet should need to know. By narrowing down all his advice for the future down to a few simple words, Vonnegut emphasizes what's most important in life. At the same time, he lets his frustration with all the people who obviously don't get it leak through just a little.

5. "She was a fool, and so am I, and so is anyone who thinks he sees what God is doing."

A couple of pages into Cat's Cradle, protagonist Jonah/John recalls being hired to design and build a doghouse for a lady in Newport, R.I., who "claimed to understand God and His Ways of Working perfectly." With such knowledge, "she could not understand why anyone should be puzzled about what had been or about what was going to be." When Jonah shows her the doghouse's blueprint, she says she can't read it. He suggests taking it to her minister to pass along to God, who, when he finds a minute, will explain it "in a way that even you can understand." She fires him. Jonah recalls her with a bemused fondness, ending the anecdote with this Bokonon quote. It's a typical Vonnegut zinger that perfectly summarizes the inherent flaw of religious fundamentalism: No one really knows God's ways.

6. "Many people need desperately to receive this message: 'I feel and think much as you do, care about many of the things you care about, although most people do not care about them. You are not alone.'"

In this response to his own question—"Why bother?"—in Timequake, his last novel, Vonnegut doesn't give a tired response about the urge to create; instead, he offers a pointed answer about how writing (and reading) make a lonesome world a little less so. The idea of connectedness—familial and otherwise—ran through much of his work, and it's nice to see that toward the end of his career, he hadn't lost the feeling that words can have an intimate, powerful impact.