Clonazolam is a research chemical which
is also known as Clonitrazolam. Clonazolam is a novel depressant
substance that belongs to benzodiazepine chemical class that give
muscle relaxant, anxiolytic, sedative and amnesic effects. it is
derived from FDA-approved compounds.

• History of clonazolam

For the first time, clonazolam was
synthesized in 1971. It is considered as the most active research
chemical which is tested in series. Clonazolam is famous for being
highly potent and that’s why it is prone to be highly risky yet
less than other designer benzodiazepines. It is so because of their
capability of producing sedation and amnesia doses at very low levels
such as 0.5 mg, or 500 micrograms (ug). Clonazolam is reported as a
chemical which has a medium-length onset of action approximately for
20 - 60 minutes.

• Chemistry of Clonazolam

Clonazolam belongs to benzodiazepine
class. All the research chemicals who belong to Benzodiazepine class
contain fused rings of diazepine ring and a benzene ring. It’s
seven-member rings in which 2 nitrogen are substituted at the place
of R4 and R1. Clonazolam also contains a fused 1-methylated triazole
ring at the position of R2 and R1 in diazepine ring. Clonazolam also
possessed triazolobenzodiazepines which is a fused triazole ring as
well as other rings like nitrobenzodiazepine, which contain a nitro
(NO2-) group.

• Pharmacology of Clonazolam

Clonazolam when binds with
benzodiazepine receptor site it produces the variety of effects. It
also expands the efficiency and effects in terms of neurotransmitter
gamma aminobutyric acid (GABA) through receptors. This site is a
prolific inhibitory receptor in the brain. The variation of the
results of this research chemical in an aspect of calming effects on
the nervous system. The basic properties of benzodiazepines bind with
the voltage-dependent sodium channels instead of more particularly
benzodiazepine receptors.

• Subjective effects of Clonazolam

Clonazolam appears to be parallel to
alprazolam and other members of benzodiazepines class. This research
chemical promotes the suppress emotions as well as comfort the body
and enhance relax feelings. It is most prominent in pre-existing
anxiety. Numerous anecdotal reports which are given by users have
claimed that it is most euphoric benzodiazepines. This drug has
numerous cognitive effect which is mainly related to amnesic and not
only this it also includes other typical effects which are commonly
seen with benzodiazepines. It is also termed as “blackouts"
when it is taken at higher rates even more than the other
benzodiazepines.