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YosefBuganim

The molecular basis of cell fate decisions

My lab is interested in identifying the components (e.g. transcription factors, chromatin remodelers, epigenetic marks and metabolites) that determine cellular identity and the elements that can force cells to acquire an alternative fate. We study two major cell fate decision processes in the embryo: (i) Embryo vs placenta and (ii) sex determination. To that end we employ nuclear reprogramming, embryo manipulation and single-cell technologies.