Center for Translation Research and Implementation Science (CTRIS)

The Center for Translation Research and Implementation Science (CTRIS) is part of the National Heart, Lung, and Blood Institute (NHLBI), one of 27 institutes and centers at the National Institutes of Health (NIH). CTRIS plans, fosters, and supports an integrated and coordinated program of research to understand the multi-level processes and factors that are associated with successful integration of evidence-based interventions within specific clinical and public health settings such as worksites, communities, and schools; identifies and makes readily available to implementation and dissemination practitioners emergent knowledge about the late phases of translation research, especially the "T4" phase, for rapid and sustained adoption of effective interventions in real world settings; leads the NHLBI effort in the rigorous, systematic evidentiary reviews and subsequent NHLBI participation in the collaborative model for clinical practice guidelines development; supports training and career development of personnel in "T4" translation research and health inequities relating to heart, lung, and blood diseases; provides a focal point for advice and guidance on matters pertaining to minority health, health inequities and minority participation in research; represents the NHLBI to other governments, other Federal Departments and agencies, international organizations, and the private sector on global health issues; and provides data analytics and portfolio analysis to evaluate and inform future directions of implementation research programs.

CTRIS Office of the Director Branch

The CTRIS Office of the Director Branch plans, coordinates, and manages activities of all CTRIS subdivisions; fosters and coordinates inter-NHLBI and interagency collaborative national and international research translation, dissemination and utilization activities, and knowledge network activities; develops and maintains the necessary technical management capability to foster and guide effective national and international research translation, dissemination, and utilization programs; and provides administrative and crosscutting technical support and coordination to achieve NHLBI strategic planning goals and objectives.

Translation Research Branch

The Translation Research Branch supports and fosters research in the late phases of research translation, especially the "T4" phase that leads to generalizable knowledge about heart, lung, and blood diseases and sleep disorders in real world settings; supports an integrated and coordinated program of research to understand the multi-level processes and factors that are associated with successful integration of evidence-based interventions within specific settings such as worksites, communities, or schools; explores initiatives that address research questions at the interface of the biomedical and socio-ecological domains to include bio-behavioral, environmental, and healthcare approaches to reduce the occurrence and consequences of heart, lung and blood diseases and related disparities; and facilitates trans-disciplinary research collaborations and serves as the focal point at NHLBI for maximizing population-level impact of NHLBI research discoveries.

In collaboration with other CTRIS branches and NHLBI divisions, the Translation Research Branch identifies gaps in translation research knowledge to inform the development of future research opportunities and promotes collaboration among research investigators, research networks, professional organizations, scientific academies, and major funders of research domestically and globally.

Implementation Science Branch

The Implementation Science Branch leads the NHLBI effort in the rigorous, systematic evidentiary reviews and subsequent NHLBI participation in the collaborative model for clinical practice guidelines development; identifies and makes readily accessible to implementation and dissemination practitioners emergent knowledge about the late phases of research translation, especially the "T4" phase in real world settings, for rapid translation into applications to enhance dissemination and implementation in real world settings of knowledge for the prevention and management of heart, lung, and blood diseases and blood disorders; provides scientific expertise and technical assistance to enhance NHLBI grantees' implementation and dissemination plans and practices; identifies knowledge gaps in research translation, especially in the "T4" phase in real world settings, for informing future research opportunities; and facilitates knowledge exchange opportunities, through knowledge networks and other strategies, for researchers and users of translation research, especially the "T4" phase in real world settings, to discuss issues of research applicability relevance, and utility to inform future research needs and opportunities.

Health Inequities and Global Health Branch

The Health Inequities and Global Health Branch serves as the NHLBI focal point for advice and guidance on research pertaining to health inequities, domestically and globally, including identifying gaps and needs as well as research opportunities to address them; supports the strategic development of "T4" translation research and implementation science in the global arena; represents the NHLBI to other governments, other Federal Departments and agencies, other NIH Institutes and Centers, international organizations, and the private sector on global health issues; develops strategy positions related to the determinants of health inequities and global health and facilitates the involvement of the Public Health Service in support of these positions and in collaboration with other agencies and organizations; and provides leadership and coordination for bilateral programs with selected countries, in support of Presidential and Vice Presidential initiatives within the Executive Branch.