No Sugar, No Starch, No Artificial Colors, No Artificial Flavors, No Preservative, No Wheat, No Gluten, No Corn, No Dairy, Yeast Free.

Warning: Consult your physician prior to using this product if you are pregnant, nursing, taking medication, or have a medical condition. Discontinue use two weeks prior to surgery.

Keep out of reach of children.

Distributed by: General Nutrition Corporation Pittsburgh, PA 15222

Health Notes

Disclaimer:
This scientific independent research is provided by Aisle7 and is for informational use only. GNC provides this information as a service but does not endorse it. Likewise, Aisle7 does not recommend or endorse any specific products.

For an herb, supported by traditional use but minimal or no scientific evidence. For a supplement, little scientific support.

Our proprietary "Star-Rating" system was developed to help you easily understand the amount of scientific support behind each supplement in relation to a specific health condition. While there is no way to predict whether a vitamin, mineral, or herb will successfully treat or prevent associated health conditions, our unique ratings tell you how well these supplements are understood by the medical community, and whether studies have found them to be effective for other people.

For over a decade, our team has combed through thousands of research articles published in reputable journals. To help you make educated decisions, and to better understand controversial or confusing supplements, our medical experts have digested the science into these three easy-to-follow ratings. We hope this provides you with a helpful resource to make informed decisions towards your health and well-being.

This supplement has been used in connection with the following health conditions:

Dose: 0.9 mg daily per pound of body weight with a doctor's supervision
CoQ10 enhances the production of energy in the heart muscle and has been reported to help people with CHF, sometimes dramatically.
(more)

Dose: Refer to label instructionsCoQ10 levels have been found to be low in people with COPD. Supplementing with CoQ10 improved blood oxygenation, exercise performance, and heart rate in one study.(more)

Dose: Refer to label instructionsCoQ10 is a nutrient used by the body to produce energy. While its exact role in the formation of sperm is unknown, even small amounts appear to increase sperm count and motility.(more)

Dose: Refer to label instructionsIn one trial, people with HIV who took CoQ10 experienced no further infections for up to seven months, and counts of infection-fighting white blood cells improved in some cases.(more)

Both preliminary1, 2, 3 and double-blind4, 5 trials have reported that supplementation with coenzyme Q10 (CoQ10) leads to a significant decrease in blood pressure in people with hypertension. Much of this research has used 100 mg of CoQ10 per day for at least ten weeks.

Coenzyme Q10 contributes to the energy-making mechanisms of the heart. Angina patients given 150 mg of coenzyme Q10 each day have experienced greater ability to exercise without experiencing chest pain.1 This has been confirmed in independent investigations.2

Dose: 0.9 mg daily per pound of body weight with a doctor's supervision

As is true for several other heart conditions, coenzyme Q10 (CoQ10) has been reported to help people with congestive heart failure,1, 2 sometimes dramatically.3 Positive effects have been confirmed in double-blind research4 and in an overall analysis of eight controlled trials.5 However, some double-blind trials have reported modest6 or no improvement7, 8, 9 in exercise capacity or overall quality of life. Most CoQ10 research used 90-200 mg per day. The beneficial effects of CoQ10 may not be seen until after several months of treatment. In one preliminary trial, treatment with ubiquinol (the chemically reduced form of CoQ10) was beneficial for people with severe heart failure, after the standard form of CoQ10 had been ineffective.10 Discontinuation of CoQ10 supplementation in people with congestive heart failure has resulted in severe relapses and should only be attempted under the supervision of a doctor.11

People with dilated congestive cardiomyopathy (DCM) have been shown to be deficient in coenzyme Q10.1 Most studies using coenzyme Q10 in the treatment of cardiomyopathy have demonstrated positive results, including improved quality of life, heart function tests, and survival rates.2, 3, 4 Coenzyme Q10 also has been shown to improve cardiac function in people with hypertrophic cardiomyopathy-a less common form of cardiomyopathy.5 A few studies, however, have found no benefit from CoQ10 supplementation in treating people with cardiomyopathy.6, 7 Despite a lack of consistency in the outcomes of published research, many doctors recommend that 100 to 150 mg be taken each day, with meals.

Researchers have also given coenzyme Q10 (CoQ10) to people with COPD after discovering their blood levels of CoQ10 were lower than those found in healthy people.1 In that trial, 90 mg of CoQ10 per day, given for eight weeks, led to no change in lung function, though oxygenation of blood improved, as did exercise performance and heart rate. Until more research is done, the importance of supplementing with CoQ10 for people with COPD remains unclear.

Blood levels of coenzyme Q10 have been found to be low in about one-third of migraine sufferers.1 In a preliminary trial, supplementation of migraine sufferers with 150 mg per day of coenzyme Q10 for three months reduced the average number of days with migraine headaches by 60%.2 The beneficial effect of coenzyme Q10 was confirmed in a four-month double-blind study. By the fourth month of treatment, a reduction in migraine frequency of 50% or greater occurred in 47.6% of people receiving 100 mg of coenzyme Q10 three times a day, but in only 14.4% of those receiving a placebo (a statistically significant difference).3 However, another double-blind trial found that coenzyme Q10 was not more effective than a placebo in children with recurrent migraines, although children receiving coenzyme Q10 appeared to improve faster than those given the placebo.4

Dose: Refer to label instructionsIn a preliminary trial, supplementing with coenzyme Q10 (100 mg three times per day for three months) resulted in significant improvements in headaches and overall symptoms in patients with fibromyalgia.1 In another study, cellular levels of CoQ10 were significantly lower in women with fibromyalgia than in healthy women. In the same study, ten women with fibromyalgia received 300 mg of CoQ10 per day for three months. Significant improvements were seen in symptoms such as fatigue, pain, depression, and anxiety.2 A placebo-controlled trial confirmed that CoQ10, in the amount of 100 mg 3 times per day, can improve depression in people with fibromyalgia.3

Dose: 120 mg daily of a standardized herbal extractCoenzyme Q10 (CoQ10) is needed for normal blood sugar metabolism. Animals with diabetes have been reported to be CoQ10 deficient. People with type 2 diabetes have been found to have significantly lower blood levels of CoQ10 compared with healthy people.1 In one trial, blood sugar levels fell substantially in 31% of people with diabetes after they supplemented with 120 mg per day of CoQ7, a substance similar to CoQ10.2 The importance of CoQ10 supplementation for people with diabetes remains an unresolved issue, though some doctors recommend approximately 50 mg per day as a way to protect against possible effects associated with diabetes-induced depletion.

A double-blind trial showed that coenzyme Q10, 120 mg per day, reduced glucose and insulin blood levels in people with high blood pressure and heart disease.1 These results suggest that coenzyme Q10 may improve insulin sensitivity in people with components of IRS, but more research is needed.

Dose: Refer to label instructionsCoenzyme Q10 (CoQ10) is needed for normal blood sugar metabolism. Animals with diabetes have been reported to be CoQ10 deficient. In one trial, blood sugar levels fell substantially in 31% of people with diabetes after they supplemented with 120 mg per day of CoQ7, a substance similar to CoQ10.1 In people with type 1 diabetes, however, supplementation with 100 mg of CoQ10 per day for three months neither improved glucose control nor reduced the need for insulin.2 The importance of CoQ10 supplementation for people with diabetes remains an unresolved issue, though some doctors recommend approximately 50 mg per day as a way to protect against possible effects associated with diabetes-induced depletion.

Strenuous physical activity lowers blood levels of coenzyme Q10 (CoQ10).1 However, while some studies have shown that CoQ10 improves the way the healthy body responds to exercise,2 other studies have found no improvement.3, 4, 5, 6 A few studies, using at least four weeks of CoQ10 supplementation at 60 to 100 mg per day, have reported improvements in measures of work capacity ranging from 3 to 29% in sedentary people and from 4 to 32% in trained athletes.7 However, recent double-blind and/or placebo-controlled trials in trained athletes, using performance measures such as time to exhaustion and total performance, have found either no significant improvement or significantly poorer results in those taking CoQ10.8, 9, 10

One double-blind study found that supplementation with ubiquinol (the chemically reduced form of CoQ10) in the amount of 300 mg per day for 6 weeks improved maximum power output in a group of trained athletes.11

In a double-blind study, supplementation with a proprietary blend of acetyl-L-carnitine, omega-3 fatty acids from fish oil, and coenzyme Q10 for 12 months resulted in an improvement in both visual function and in objective findings on eye examination (a decrease in the drusen-covered area on the retina).1

In a preliminary report, two people with a hereditary form of Alzheimer's disease received daily: coenzyme Q10 (60 mg), iron (150 mg of sodium ferrous citrate), and vitamin B6 (180 mg). Mental status improved in both patients, and one became almost normal after six months.1

Dose: 50 to 60 mg dailyPreliminary evidence has linked gingivitis to a coenzyme Q10 (CoQ10) deficiency.1 Some researchers believe this deficiency could interfere with the body's ability to repair damaged gum tissue. In a double-blind trial, 50 mg per day of CoQ10 given for three weeks was significantly more effective than a placebo at reducing symptoms of gingivitis.2 Compared with conventional approaches alone, topical CoQ10 combined with conventional treatments resulted in better outcomes in a group of people with periodontal disease.3, 4

Nutritional supplements recommended by some doctors for prevention and treatment of periodontitis include vitamin C (people with periodontitis are often found to be deficient),1vitamin E, selenium, zinc, coenzyme Q10, and folic acid.2 Folic acid has also been shown to reduce the severity of gingivitis when taken as a mouthwash.3

In a double-blind study, supplementation with a proprietary blend of acetyl-L-carnitine, omega-3 fatty acids from fish oil, and coenzyme Q10 for 12 months resulted in an improvement in both visual function and in objective findings on eye examination (a decrease in the drusen-covered area on the retina).1

Pregnant women with preeclampsia have significantly lower plasma coenzyme Q10 levels, when compared with women with healthy pregnancies. In a double-blind study at women who were at high risk of developing preeclampsia, supplementing with coenzyme Q10 reduced the incidence of preeclampsia by 44%. The amount used was 200 mg per day; treatment was begun during the twentieth week of pregnancy and continued until delivery.1

Coenzyme Q10 (CoQ10) is a nutrient used by the body in the production of energy. While its exact role in the formation of sperm is unknown, there is evidence that as little as 10 mg per day (over a two-week period) will increase sperm count and motility.1 In one study, men with low sperm counts were given CoQ10 (60 mg per day for about three months). No significant change was noted in most sperm parameters, but a significant improvement was noted in in-vitro fertilization rates.2

In a preliminary trial, supplementation with coenzyme Q10 (CoQ10) in the amount of 100 mg three times per day for 16 weeks significantly improved tinnitus in people who had initially low blood levels of CoQ10. However, CoQ10 was not beneficial for people whose initial blood levels were not low.1

Blood levels of coenzyme Q10 (CoQ10) were also found to be low in people with HIV infection or AIDS. In a small preliminary trial, people with HIV infection took 200 mg per day of CoQ10. Eighty-three percent of these people experienced no further infections for up to seven months, and the counts of infection-fighting white blood cells improved in three cases.1

Dose: Refer to label instructionsIn a double-blind study of 21 patients with chronic renal (kidney) failure, 15 of whom were on dialysis, supplementation with 60 mg of CoQ10 three times per day for four weeks improved certain measures of kidney function (BUN [blood urea nitrogen], serum creatinine, and creatinine clearance), compared with placebo, and eliminated the need for dialysis in some patients.Singh RB, Khanna HK, Niaz MA. Randomized, double-blind placebo-controlled trial of coenzyme Q10 in chronic renal failure: discovery of a new role. J Nutr Environ Med 2000;10:281-8. Because chronic renal failure is a serious and complicated disease, individuals with this condition should take CoQ10 only under strict medical supervision.

Coenzyme Q10 (CoQ10) is also called ubiquinone, a name that signifies its ubiquitous
(widespread) distribution in the human body. CoQ10 is used by the body to
transform food into
adenosine triphosphate (ATP), the energy on which the body runs.

The information presented in Aisle7 is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires June 2016.

Label

To view the Label you will need Adobe Acrobat Reader installed. You can download a free copy of the Adobe Acrobat Reader at: http://www.adobe.com/acrobat/readstep.html