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We have read with great interest the article from Deng and colleagues1 reporting on the results of a randomised, controlled clinical trial of allogeneic umbilical cord-derived mesenchymal stem cells (UC-MSCs) for lupus nephritis. The study demonstrated that the administration of intravenous UC-MSCs does not provide additional benefit to conventional immunosuppression.

Over the last decade, increasing evidence has indicated that UC-MSCs are multipotent cells with promising applications to regenerative medicine2 and also a powerful tool to modulate the immune system. UC-MSCs can interact with most immune cell types via both cell–cell contact and secretion …

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