FASEB Journal: Caloric intake and muscle mass at high altitude

New research in The FASEB Journal explored why a group of young, healthy adults residing at high altitude lost muscle mass while severely underfed and consuming the same high-protein diet that preserved muscle during weight loss at sea level.

A team led by Stefan M. Pasiakos, PhD, a nutritional physiologist at the U.S. Army Research Institute of Environmental Medicine, examined eight participants from a larger randomized controlled study. The larger study compared the effects of standard versus high-protein diets on a group of healthy young men hiking at high altitude who experienced increased exercise levels and decreased caloric intake.

Pasiakos and colleagues found that the combination of unaccustomed high-altitude exposure and negative caloric balance resulted in the development of anabolic resistance, or inability to build muscle mass -- a phenomenon mainly observed in older adults.

"Findings from our study show that after prolonged exposure to environmental stress and underfeeding, the body's ability to build and repair muscle was suppressed," Pasiakos explains. "These data highlight the fundamental relationship between caloric balance and skeletal muscle, and suggest that if efforts to maximize food intake are not prioritized during high-altitude sojourns, muscle mass will be lost."

The study underscores the importance of maintaining caloric balance at high altitudes, especially among unaccustomed lowlanders. The findings could also have potential implications for individuals with chronic obstructive pulmonary disease (COPD), which decreases oxygen delivery to the body and is often accompanied by both weight loss and lean mass loss.

"Although this study was cast in a high-altitude context, it has revealed unanticipated and potentially broader metabolic complexity that may apply at sea level," said Thoru Pederson, PhD, Editor-in-Chief of The FASEB Journal. "One cannot resist saying this work takes the subject to a higher level."

-end-

This research was supported, in part, by the U.S. Army Medical Research and Materiel Command.

The FASEB Journal is published by the Federation of the American Societies for Experimental Biology (FASEB). The world's most cited biology journal according to the Institute for Scientific Information, it has been recognized by the Special Libraries Association as one of the top 100 most influential biomedical journals of the past century. Receive monthly highlights for The FASEB Journal; subscribe at http://www.faseb.org/fjupdate.aspx.

FASEB is composed of 30 societies with more than 130,000 members, making it the largest coalition of biomedical research associations in the United States. Our mission is to advance health and well-being by promoting research and education in biological and biomedical sciences through collaborative advocacy and service to our societies and their members.

Federation of American Societies for Experimental Biology

Related Weight Loss Articles:

Green tea may help with weight loss effortsIn an analysis published in Phytotherapy Research of randomized controlled trials, individuals who consumed green tea experienced a significant decline in body weight and body mass index.

Changing weight-loss strategies, attemptsThe proportion of adults who tried to lose weight in the previous year increased from 1999 to 2016 but the findings of this observational study suggest the results may have been unsatisfactory.

Weight loss medicines underutilized by veteransDespite the availability of new weight management medications and several clinical guidelines recommending their use as part of a comprehensive treatment plan for obesity, a new study has found that their use is extremely low (about one percent) among eligible Veterans.

Mindfulness training may help support weight lossMindfulness training may improve the effectiveness of intensive weight management programs, according to a small study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism.

Trending Science News

Top Science Podcasts

Clint SmithThe killing of George Floyd by a police officer has sparked massive protests nationwide. This hour, writer and scholar Clint Smith reflects on this moment, through conversation, letters, and poetry.

#562 Superbug to BedsideBy now we're all good and scared about antibiotic resistance, one of the many things coming to get us all. But there's good news, sort of. News antibiotics are coming out! How do they get tested? What does that kind of a trial look like and how does it happen? Host Bethany Brookeshire talks with Matt McCarthy, author of "Superbugs: The Race to Stop an Epidemic", about the ins and outs of testing a new antibiotic in the hospital.

GrahamIf former Minneapolis police officer Derek Chauvin's case for the death of George Floyd goes to trial, there will be this one, controversial legal principle looming over the proceedings: The reasonable officer.
In this episode, we explore the origin of the reasonable officer standard, with the case that sent two Charlotte lawyers on a quest for true objectivity, and changed the face of policing in the US.
This episode was produced by Matt Kielty with help from Kelly Prime and Annie McEwen.
Support Radiolab today at Radiolab.org/donate.