Distinct functions for C2GlcNAcT-I in the differential elaboration of endothelial venule glycoproteins that set a threshold for the amount of L-selectin (show SELL Antibodies) needed for lymphocyte homing.

data demonstrate that multiple C2GlcNAcT enzymes can contribute to P-selectin (show SELP Antibodies) ligand formation and may cooperate with C2GlcNAcT-I in the control of CD8 (show CD8A Antibodies) T cell trafficking

IGnT deficient mice had reduced spontaneous locomotive activity, and the number of peripheral blood lymphocytes was also reduced and renal function decreased in the deficient mice

GCNT1 Antigen Profile

Protein Summary

This gene is a member of the beta-1,6-N-acetylglucosaminyltransferase gene family. It is essential to the formation of Gal beta 1-3(GlcNAc beta 1-6)GalNAc structures and the core 2 O-glycan branch. The gene coding this enzyme was originally mapped to 9q21, but was later localized to 9q13. Multiple alternatively spliced variants, encoding the same protein, have been identified.