P DavanzoDepartment of Psychiatry and Behavioral Sciences, School of Medicine, University of California, Los Angeles 90024, USANeuropsychopharmacology 24:359-69. 2001

..Follow-up studies involving a larger sample may allow us to confirm whether changes in myo-inositol associated with acute lithium therapy persist in long-term clinical response of patients with and without lithium compliance...

..Lamotrigine appears to reduce glutamine levels associated with treatment remission. Further study is encouraged to determine if these MR spectroscopic markers can delineate drug mechanism of action and subsequent treatment response...