In this work, we propose a energy harvesting active pixel sensor with serially connected photodiodes using deep N-well for significantly reducing power consumption of the CMOS image sensor (CIS). Deep N-well layer was used for the isolation of pixels. The proposed energy harvesting APS is capable of imaging and energy harvesting (EH) on the same focal plane without any complex circuits. The N+/P-well diode can be used as the photodetector in the imaging mode and as the energy harvesting feature in the EH mode. In EH mode, in order to supply the power of the imaging pixel, neighboring pixels work as the micro solar cell. Simulation results show that the output swing of the proposed image sensor is 800 mV without external supply voltage. Standard 0.18 μm CMOS process technology is being used for the fabrication of the proposed energy harvesting APS. The proposed APS might be useful for low power applications using CMOS image sensors.