Have you ever had a gin and tonic with house-made tonic water? How about a fizz or sour? Perhaps a fun tiki drink? Maybe a glass of eerie, smoking cauldron punch? Those are all tasty cocktail options, but as M. Carrie Allan (no relation) at Imbibe Magazine explains, they can also be hazardous in some situations.

Tonic water made in-house, for example, can contain too much quinine—usually made from cinchona bark—and cause cinchonism, a type of poisoning with symptoms like blurred vision, impaired hearing, vertigo, and nausea. Raw eggs used in fizzes and sours can carry Salmonella bacteria, and most tiki bar drinks actually rely on various nuts to give off that island-style flavor, which is problematic for those with allergies. Orgeat, for instance, used in Mai Tais, Royal Hawaiians, and most tropical-flavored party punches, is essentially an almond syrup. And when you see a cocktail giving off a some cool vapor effects, it’s because of dry ice. An overzealous drinker who’s all too captivated by the spectacle could accidentally ingest some and get the lining of their stomach frozen.

If you frequent some really hip establishments, you may have seen black cocktails or drinks listed as having “infusions” of some kind. Those nifty opaque black beverages are made using activated charcoal, which isn’t poisonous but highly absorptive. It can mess with the medications you’re taking, including heart medication, antidepressants, and even birth control. And those “infusions” can contain botanicals like cinchona and wormwood (which can contain toxic thujone), or possibly tobacco. Some bar owners use tobacco to make bitters and tinctures—like for Manhattans or Old Fashioneds—but the amount of nicotine in these types of infusions is likely much higher than what you’d get from lighting up a cigarette. Ingesting too much tobacco this way could be a one-way ticket to nicotine poisoning.

That’s not all though, uncleaned citrus peel, elderberries, grapefruit, nutmeg, floral garnishes, and even cannabis are possible cocktail ingredients that can turn a fun night of drinking into a less fun night at the emergency room. Most places will put warnings about these ingredients on their menus, but let’s be honest, how many of us are going to read all that when we just want to get a drink and go hang out with our friends?