The Institute of Physiological Chemistrys scientific work groups focus on mechanisms of cell and tissue damage.

The effects of reactive species of oxygen and nitrogen, of oxygen deprivation, of cold storage, and of mechanical trauma on such damage are studied using models ranging in complexity from chemical systems to cultured cells, perfused organs, patient samples and animal models.

In addition to basic research, the aim is to develop novel therapeutic approaches.

Fields of Research

Investigation of liver, bowel, and other organ damage caused by ischemia and subsequent reperfusion

Investigation of tissue damage in trauma and shock

Studies of cold induced apoptosis

Studies of nitrogen monoxide transport by nitroso compounds and of nitrogen monoxide release by physiological metabolites

Investigation of the kryopreservation of critical cell types

Development of an organ protective solution for transplant medicine and cardiac surgery

Development of protective solutions for isolated cells and tissues for use in biotechnology

Development of anti-oxidants with iron complexing and hydrogen peroxide degrading properties

Development of nano capsules as artificial oxygen carriers (blood replacement)

Staff

The Institute employs 18 physicians and scientists and 16 other employees.