Results:

Are summarized in table 1. Rs6754031 nucleotide distribution was significantly different in both groups (p = 0.036) mostly due to an absence of GG genotype in controls. Interestingly, patients with this rs6754031 GG genotype had higher total FIQ scores, than patients with the other two rs6754031 genotypes (p = 0.039). Table 2.

Table 1. Nucleotide distribution.

Rs-6754031

Patients

Controls

P value

n

73

48

Age (mean ± SD)

44.7 ± 12.8

42.8 ± 12.3

ns

Genotype

n (%)

n (%)

GG

8 (11)

0 (0)

GT

24 (33)

15 (31)

0.036

TT

41 (56)

33 (69)

Table 2. Total FIQ score in patients with Rs-6754031

Rs-6754031 Genotype

Percentile 25

FIQ score

P value

Median

Percentile 75

GG

69.74

80.38

88.74

0.039

GT

58.55

63.29

77.53

TT

64.23

71.25

77

Conclusions:

In this ethnic group, a disabling form of FM was associated to a particular SCN9A gene variant. These preliminary results raise the possibility that patients with severe FM may have a sodium channelopathy.