In the previous verse Jesus mentioned that there would be those who had called him Lord (kyrie) who would not enter the Kingdom of Heaven. In this verse he notes that even some who have performed miracles in his name would also be excluded. The verse does not deny that these unholy may have made correct prophecies and driven out demons. These were acts that in that era were commonly attributed to teachers and mystics. Davies and Allison note that Jesus never calls upon his followers to perform such feats. Rather in the previous verses he calls for basic charity and piety. To Davies and Allison this verse is a special condemnation of mighty works, and emphasizes the importance of lesser works that might not bring fame to the practitioner.[1] This verse has also been used as evidence by Protestants for the doctrine of justification by faith.

This is return to the theme of the parable of the narrow door of Matthew 7:13,[2] with the word many emphasizing that there is a considerable number of individuals who claim special dispensation from Jesus, but who will not be admitted to the kingdom.[3] Unlike the wolves in sheep's clothing at Matthew 7:15, these charismatics seem surprised to be condemned and to have believed themselves to be holy. The phrase "in that day" is a clear eschatological link to the Last Judgement.[4] Hare, Douglas claims that the phrasing of the verse makes it clear that the voice speaking is of those who have already been condemned and who are appealing to Jesus. This is evidence for the standard interpretation that in these verses God the Father is the ultimate judge, and Jesus plays a secondary role as an advocate or witness.[5]