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Nitroglycerin increased cardiac output

mean 7) who formed group I and for ten patients with elevated PAW (> 12 mm Hg; mean 19) who com- fall in cardiac output. Thus, the principal action of sublingual NTG in AMI appears to be systemic venodila- tion with consequent reduction of ventricular preload. THE REMARKABLE EFFICACY of nitroglycerin. Increased intracellular cGMP inhibits calcium entry into the cell, thereby decreasing intracellular calcium concentrations and causing smooth muscle relaxation (click Systemic arterial dilation reduces afterload, which can enhance cardiac output while at the same time reducing ventricular wall stress and oxygen demand.

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With an open-chest dog preparation, which makes it possible to measure simultaneously the cardiac output, the coronary flow and the systomic arterial pressure, the actions of nitroglycerin on the coronary circulation were invcstigated. The results show that nitroglycerin, injected as a single intravenous dose or by slow. Cardiac output increased in treated patients, especially those with left ventricular failure, but decreased in the control group. Mean arterial pressure decreased to the same degree in treated patients and in controls. Key words: intravenous nitroglycerin, recent myocardial infarction, long-term effects, increase in cardiac output.