Abstract

Objective

To determine whether there was an association between the Five-Times-Sit-to-Stand test (FTSS) and the global cognitive function assessed with Short-Portable-Mental-State-Questionnaire (SPMSQ) among the EPIDOS cohort.

Design

Cross-sectional study corresponding to the baseline assessment of the EPIDOS study.

Setting

Five French cities including Amiens, Lyon, Montpellier, Paris and Toulouse.

Results

Compared to their counterparts, the women with cognitive impairment (n=1190, mean 81.51±0.45years) took more time in performing FTSS (17.8±0.9seconds versus 16.1±0.3seconds, P < 0.001). There was a significant negative association of SPMSQ score with FTSS (Unadjusted β=−0.02(95%CI −0.03;−0.01), P<0.001; Fully Adjusted β=−0.03(95%CI −0.05;−0.01), P=0.003; Stepwise Backward Adjusted β=−0.02(95%CI −0.04;−0.01), P=0.005), as well as with advance in age (β=−0.04, P=0.006) and vitamin D deficiency (β=−0.34, P=0.011). The FTSS limit value in predicting moderate cognitive impairment was set at 15 seconds by a sensitivity analysis (negative predictive value=86%).

Conclusion

We found a negative association of FTSS with global cognitive performance. Achieving FTSS in less than 15 seconds made unlikely the existence of a moderate cognitive impairment. FTSS could be used as a tool in primary care medicine to exclude moderate cognitive decline.