The state of the microsomal oxidative system of the rat liver in the postoperative period

Abstract: A functional state of microsomal enzymatic system was studied in liver tissue of rats within 24, 48 and 72 hrs after surgical operation. Factors of operational treatment and of postoperational period were shown to inhibit distinctly amidopyrine demethylase as well as to decrease the content of cytochromes P-450 and b5 and the glycogen concentration in liver tissue. Content of lactic and pyruvic acids was increased in blood. Depression of the functional state of liver microsomes, occurred as a result of hypoxia, appears to be responsible for the phenomenon of elevated drug toxicity during postoperational period.