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To limit the variations caused by instrument-related factors, only those MRIs taken at the Chonnam National University Hospital were selected for the analysis. MRI examinations were conducted using a 1. FLAIR and T2-weighted images were used to detect abnormal ventricular dilatation and white matter lesions.

MRI data were processed using FreeSurfer v6. All image-processing steps were performed by one imaging expert B.

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K who was blinded to all the clinical information. The subcortical volume was measured automatically using FreeSurfer. The automated procedures for volumetric measurements of the different brain structures have been described previously 16 , The segmentation was visually inspected for accuracy and correct segmentation was ascertained. Any geometric inaccuracies or topological defects were corrected using a combination of automatic and manual methods. Confirmation of the segmentation and manual editing was performed by an imaging expert B.

Calculation of total intracranial volume was done using FreeSurfer, as described previously The volumes of all cortical and subcortical structures were adjusted for the total intracranial volume in each patient. SPSS version The normality of distribution was verified using the Shapiro-Wilk normality test, and parametric or nonparametric tests were subsequently used.