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what do we do when a research company has a breakthru that could help hiv but they are focusing on cancer

could this antibody save people without so many side effects?

here is another anti-cd antibody with (after i researched it) anti-hiv properities possibly but medarex is not doing hiv trials.

MDX-1401 is anti-CD30 antibody

High serum level of the soluble form of CD30 molecule in the early phase ofHIV-1 infection as an independent predictor of progression to AIDS

Elevated serum levels of soluble (s)CD30 as well as following infection with human immuno-deficiency virus (HIV).

CD30 induces HIV expression in chronically infected T cells

independent prognostic indicator of disease progression, and the suggested role of CD30 in HIV-1 infection

Role for CD30 in HIV expression. ... Thus, CD30 triggering may play an important rolein both HIV replication and the death of HIV-infected CD4+ T cells

anti-CD30L antibody also exerted a suppressive effect on the spontaneous HIV replication occurring in lymph node cells, freshly derived from an HIV-seropositive patient showing CD30 expression in B cells and in a proportion of CD8+ T lymphocytes. Thus, CD30 triggering may play an important role in both HIV replication and the death of HIV-infected CD4+ T cells.

The dose-escalation, multi-dose Phase I clinical trial is expected to enroll up to36 patients with relapsed or refractory Hodgkin's disease. The trial is designed toestablish and evaluate the safety profile and initial efficacy of MDX-1401.Preclinical in vitro studies showed that this second- generation nonfucosylatedanti-CD30 antibody demonstrated enhanced antibody- dependent cellular cytotoxicity(ADCC), an important mechanism of action of therapeutic antibodies, and was activein inhibiting tumor growth in in vivo xenograft models.

"Today's announcement demonstrates our commitment to innovative approaches that havethe potential to enhance our fully human monoclonal antibody technology fordeveloping important new therapies," said Irwin Lerner, Chairman of the Board ofDirectors and Interim President and CEO of Medarex. "We are pleased with ourpartnership with BioWa and with its technology as a method for increasing thepotency of MDX-1401, a novel product that broadens our anti-CD30 clinical programfor Hodgkin's disease."CD30, Th2 cytokines and HIV infection: a complex and fascinating link.Del Prete G, Maggi E, Pizzolo G, Romagnani S.Division of Clinical Immunology and Allergy, University of Florence, Italy.

CD30 is a member of the tumor necrosis factor (TNF)/nerve growth factor (NGF) receptor superfamily, and was originally described as a marker of Hodgkin's and Reed-Sternberg cells in Hodgkin's lymphoma. CD30 is preferentially expressed on CD4+ and CD8+ T-cell clones that produce T helper 2 (Th2)-type cytokines, and is also released in a soluble form by these cells. Elevated serum levels of soluble (s)CD30 have been found in some conditions in which a pathogenic role for Th2 cells has been suggested, such as atopy, Omenn's syndrome, systemic lupus erythematosus, as well as following infection with measles virus or human immuno-deficiency virus (HIV). Here, Gianfranco Del Prete and colleagues suggest a complex and fascinating link between the expression and release of CD30, and the immunopathogenesis of HIV infection.

High serum level of the soluble form of CD30 molecule in the early phase of HIV-1 infection as an … - group of 2 »G Pizzolo, F Vinante, L Morosato, G Nadali, M … - AIDS, 1994 - ncbi.nlm.nih.govHigh serum level of the soluble form of CD30 molecule in the early phase ofHIV-1 infection as an independent predictor of progression to AIDS. ...

Vinante, A Rigo, MT Scupoli, G Pizzolo - Blood, 2002 - Am Soc Hematology... at diagnosis have been shown to be an independent prognostic indicator of diseaseprogression, 22 , 23 and the suggested role of CD30 in HIV-1 infection 15 has ...

Regulation of CD30 Antigen Expression and Its Potential Significance for Human Disease - group of 2 »ME Kadin - 2000 - ASIP... 86. CD30 appears to be important in AIDS, where activation of CD30 enhancesHIV replication in CD4+ T cells from HIV-infected individuals. ...

Role for CD30 in HIV expression. - group of 2 »S Romagnani, F Annunziato, R Manetti, F … - Immunol Lett, 1996 - ncbi.nlm.nih.govRole for CD30 in HIV expression. ... Thus, CD30 triggering may play an important rolein both HIV replication and the death of HIV-infected CD4+ T cells. ...

This review highlights the role of a CD4+CD3- accessory cell in the development of organized lymphoid infrastructures as well as in the development of high-affinity antibody responses and T-cell memory. These 2 functions are linked in the development of the vertebrate immune system and are effected by the constitutive expression of 2 sets of tumor necrosis factor (TNF) family members. The expression of lymphotoxin 3 (LT3), LT3, and TNF-3, which are closely linked genetically, affects the organization of lymphoid structures into B-cell and T-cell areas; the dual expression of OX40 ligand (TNFSF4) and CD30 ligand (TNFSF8) influences both the survival of T-cells within germinal centers and T-cell memory.

Institute of Internal Medicine and Immunoallergology, University of Florence, Italy.

CD30 is a member of the tumor necrosis factor (TNF)-receptor superfamily, whose ligand (CD30L) has been identified on B cells, activated macrophages and a subset of activated T cells. We show here that infection in vitro with human immunodeficiency virus (HIV) of CD4+ T-cell clones generated from HIV-seronegative individuals can enhance the expression of CD30, which often preceeds and is associated with the death of clonal T cells. Furthermore, cross-linking CD30 with an agonistic CD30-specific monoclonal antibody potentiated HIV replication induced by an insolubilized anti-CD3 antibody in T-cell lines generated from HIV-infected individuals. More importantly, paraformaldehyde-fixed CD8+ T-cell clones expressing CD30L enhanced HIV replication in anti-CD3-stimulated allogeneic or autologous HIV-infected CD4+ T-cell lines and such a potentiating effect was inhibited by an anti-CD30L antibody. The anti-CD30L antibody also exerted a suppressive effect on the spontaneous HIV replication occurring in lymph node cells, freshly derived from an HIV-seropositive patient showing CD30 expression in B cells and in a proportion of CD8+ T lymphocytes. Thus, CD30 triggering may play an important role in both HIV replication and the death of HIV-infected CD4+ T cells.

This is a new antibody that as shown below has important effects in HIV disease, but this company is not doing any trials on HIV patients.

Do we need activism in New Jersey to ask for at least a dialogue. Would activism and protests help the company get the publicity it needs to raise awareness so they can get the funding to do an HIV trial? Can activists in NJ meet with them to discuss these issues. Would having one hundred activists actively asking for this medicine improve thier ability to get funding? Would the publicity raise the awareness in the investor community who are always willing to invest in something they see as potentially lucrative?