This study aimed to research
the relationship between the volume changes of brain and smoking extent/nicotine
dependence. A voxel-based morphometry study between smokers grouped by smoking
amount and dependence level was conducted. This study
demonstrated the volume of many brain areas decreased with the increase in
smoking extent and an opposite correlation between some brain areas and smoking
dependence was observed. This study indicated that dependence had limited ability
to predict smoking-related brain structure changes. A comprehensive assessment
of the situation should be consulted, when clinicians make treatments options.

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