With these ideas, anybody thinking the game don't need The Bad and the Evil regime That's like saying that bad boy Piston team didn't need Isiah

Lyric Meaning

With this kind of lyrical prowess they come up with in their verses, can’t nobody say that rap doesn’t need the “BAD and EVIL” regime. They are the regime this GAME needs to stay alive

Royce compares himself and Eminem to the Detroit (their hometown) Pistons of the NBA, who during the 80s were known as “The Bad Boys” because of their physical style of play. Isiah Thomas was their star player

Isaiah is also a term used to describe the perfect form of a man (physically, mentally and all), Em' and Royce are the game’s Isaiah

Isaiah was also a prophet in the 8th-century. He and Em' are again the game’s Isaiah. This goes with the religion theme of this verse

These last two interpretations are not likely intended by Royce but are interesting nonetheless