Software: Have a total control over all the parameters through our software. Program long run experiments and automate sample injection thanks to our powerful scheduler.

Elveflow has joined forces with ALine Inc. which has a proven track record in the area to provide among different options a microfluidic chip designed for cell culture. Two independently accessible chambers are separated by a porous membrane of choice. Unlike microtiter plate based systems, these devices allow continuous flow in one or both chambers. Balancing the pressure drop across the membrane can be used to adjust the flux across the membrane.

Aline Inc has also the ability to carry your design from prototyping through development to manufacturing. Their expertise throughout the development stages enables us to ensure your design is manufacturing ready from an early stage, eliminating scale-up issues that so often plague technologies. In addition to microfluidic chip design, they have extensive experience in integrated functional solutions, such as the incorporation of electrodes, membranes and valves, integration with sensors, printed circuit boards and blister packs, and reagent deposition.

PRINCIPLE

Chip

The pack can be used either with the chip from Aline Inc, your homemade chip or any other commercial solution available

Recirculation option

One can use our MUX Inj to perform a unidirectional flow circulation to ensure cell nurturing over days

Bubble detector

One can detect potential bubble in the setup and setup an action accordingly through the software

Pressure sensors

Possibility to use one or several pressure sensors to measure the pressure drop accross the system

Cell culture on chip

Live cell imaging

Cell response to medium change

Drug screening

Toxicity tests

Stem cells assays

Organs-on-chips not only has the advantages such as miniaturization, integration and low consumption, but also it can accurately control the multi-parameters of system such a chemical concentration gradient, fluid shear stress, cell patterning, tissue-tissue interface, organ-organ interaction and so on, mimicking the complex structure, microenvironment and physiological function of human organs.

These applications hold the promise of having a significant impact on improving the predictability of drug screening models and Personalised Medicine. Organ-on-a-chip technology supports these research areas by providing an environment that can mimic the human physiology and morphology in vivo better than traditional cell culturing methods. Scalable organ-on-a-chip production is made possible by combining the enabling technologies originating from both the semiconductor and molecular biology industries.

The Sonnenburg Lab in Stanford is developing a microfluidic system to test how chemical and osmotic perturbations affect gut microbe species in the absence of host interactions. The ability to monitor the real-time dynamics of a complex microbial community during physical perturbations will allow them to characterize relevant members and key metabolic pathways involved during disruption of the normal equilibrium. They trust us and our OB1 Mk3 achieve fine-scale microfluidic control.