Microfold cell

M cells (or microfold cells) are cells found in the follicle-associated epithelium of the Peyer's patch as well as in bronchus-associated lymphoid tissue (BALT). They transport organisms and particles from the gut lumen to immune cells across the epithelial barrier, and thus are important in stimulating mucosal immunity.

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M cells differ from normal enterocytes in that they lack microvilli on their apical surface, but instead possess broader microfolds that give the cell its name. These cells are far less abundant than enterocytes. M cells do not secrete mucus or digestive enzymes, and have a thinner glycocalyx, which allows them to have easy access to the intestinal lumen for endocytosis of antigens. M cells main function is the selective endocytosis of antigens, and transporting them to intraepithelial macrophages and lymphocytes, which then migrate to lymph nodes where an immune response can be initiated.