Mutated jadinko guards appear in the Jadinko Lair east of Shilo Village, on Karamja, and require a Slayer level of 86 to kill. They are popular for the whip vine drop, as they are the only monsters besides mutated jadinko males to drop it. Using bolas on it will cause it to attack you with the nearest jade roots. Mutated jadinko guards are considerably more dangerous than their combat level suggests; having a max hit exceeding 400, and 6000 life points, a string of lucky hits can quickly kill a player. They will also switch attack styles based on your protection prayers and are difficult to safespot, so it is nearly impossible to negate all damage. While their strength and health may be very high, they have somewhat low accuracy and defence.

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Mutated jadinko guards, along with males and babies, share a similar melee and magic attack. However a guard's melee attack is strong and occasionally hits above 200. Their magic attack is also high-hitting, but it doesn't hit often with even 95 magic defence bonuses. Using protection/deflection prayers will cause them to use the other attack they have to thwart prayer flashing on them. If players use Deflect/Protect from magic and they are unable to attack you, they will attempt a whip attack with nearby vines. but the vines hit extremely low, from 1-17. This attack is also triggered when a player targets a dreadnip to attack a mutated jadinko guard. They can bid multiple vines, along with males to attack you. So if a player were to stand near middle and there were 5 vines around him and the guard/male could not reach them, it will bid all five of them to attack the player at once, which is more dangerous than the standard attacks.

Their magic attacks, along with other mutated jadinkos, seem to be a vine attack from beneath you, similar to the old special attack of the abyssal vine whip, but only hits you once.

If they manage to hit you with their magic attack, after the projectile reaches you, there's a one second delay before the damage shows up. It is unknown if it affects the babies or males, and might be an oversight from Jagex.

Their weakness appears to defy the combat triangle - they are weak against a melee style (stab), but they use melee as their primary attack style, and magic as their secondary. It is unknown whether this is intentional.