Follistatin is fascinating protein that can increase muscle mass beyond natural potential by suppressing myostatin&period; Scientists first identified follistatin while examining porcine &lpar;re&colon; pig&rpar; follicular fluid in the ovaries&period; &lsqb;1&rbrack;Follistatin is naturally found in the skeletal muscle of almost all mammals with advanced or developed characteristics&comma; such as humans&comma; rodents&comma; and cows&period; Follistatin is high in the non-essential amino acid cystine but unlike most proteins discussed in the fitness world&comma; follistatin has carbohydrates attached to it&period; &lsqb;2&rbrack;Follistatin&comma; specifically Follistatin 344 &lpar;FS344&rpar;&comma; quickly gained popularity in the bodybuilding community as a potential supplement to rapidly increase lean tissue mass&period; Another protein&comma; follistatin-related gene &lpar;FLRG&rpar; acts on similar pathways as FS344 regarding its muscle building properties&period; Increased lean tissue mass could give a bodybuilder an advantage in a competitive setting and be the differentiating factor between first and second place&period;Follistatin and Muscle GrowthFollistatin works by binding to and inhibiting transforming growth factor-β &lpar;TGF-β&rpar; peptides such as myostatin which is responsible for regulating and limiting muscle growth&period; &lsqb;3&rbrack; It's also worth pointing out that myostatin may have a regulatory role in skeletal muscle fibrosis&semi; too much myostatin can impair tissue function and cause chronic disease in vital organs&comma; tissues&comma; and bone marrow&period; &lsqb;4&rbrack; &lsqb;5&rbrack;In additional to suppressing the degenerative properties of myostatin&comma; follistatin also suppresses the pituitary gland synthesis and secretion of follicle-stimulating hormone &lpar;FSH&rpar;&period; &lsqb;1&rbrack; High FSH levels in men may indicate that testicles are not functioning correctly&semi; this condition limits muscle growth&comma; recovery&comma; and normal hormonal function&period; &lsqb;6&rbrack; However&comma; FSH levels that are too low can also negatively impact health and reproductive capabilities&period;Whereas some myostatin inhibitors like Trichostatin A &lpar;TSA&rpar; require daily administration&comma; increased levels of FS344 were observed up to 15 months after initial injection&period; &lsqb;7&rbrack;&lsqb;3&rbrack; The lack of need for daily administration makes follistatin an attractive alternative for suppressing myostatin&period;The recent increase in attention in the science community on follistatin and other myostatin inhibitors is primarily due to the desire to find an alternative means to treat muscle disorders&semi; the most popular current option is androgen steroids which pose a number of side-effects and long-term health risks&period; At this point you might be wondering why follistatin use isn't more widespread in bodybuilders and other athletes&period; In the next section we will examine the current research on follistatin and whether it builds muscle mass&period;Does Follistatin Build Muscle&quest;In short&comma; follistatin does build muscle but not necessarily in humans&period; A number of studies support the muscle-building and anti-degenerative effects follistatin in rodents&period; Unfortunately there is no formal research examining follistatin usage in human subjects but a quick Google search will yield countless amateur follistatin logs on bodybuilding and fitness forums&period;When scientists bred a mouse producing no myostatin and extra follistatin it had 117&percnt; larger muscle fibers and 73&percnt; more total muscle fibers compared to the mice in the control group&period; &lsqb;8&rbrack; This study demonstrates that follistatin positively impacts muscle growth in ways beyond simply suppressing myostatin&period; Mice with suppressed myostatin had twice the muscle mass but mice with the follistatin transgene and suppressed myostatin had four times as much muscle mass compared to the control group&period; &lsqb;7&rbrack;Administering FS344 via a small virus &lpar;re&colon; adeno-associated virus&sol;AAV&rpar; can increase muscle size and strength in animal species ranging from mice to monkeys with no significant adverse effects on organs&comma; reproductive capabilities&comma; serum estradiol &lpar;re&colon; primary female sex hormone&rpar;&comma; luteinizing hormone &lpar;LH&rpar;&comma; and FSH levels&period;&lsqb;1&rbrack; &lsqb;3&rbrack; When scientists administered follistatin in mice with spinal muscular atrophy&comma; the mice experienced increased muscle mass&comma; improved motor function&comma; and a 30&percnt; longer lifespan compared to mice in the control group&period; &lsqb;2&rbrack;Not only do increased follistatin levels correlate to increased muscle mass&comma; but a lack of the follistatin protein at birth directly correlates to less muscle mass&period; &lsqb;7&rbrack; Less muscle mass at birth can negatively impact bone&comma; organ&comma; and tissue development as well as normal hormonal function&period;

Related products&colon;MT-IIMT-IGHRP-2GHRP-6CJC-1295 with DACCJC-1295 without DACCJC-1293PEG-MGFMGF

Lyophilized peptides although stable at room temperature for 3 months&comma; should be stored desiccated below -18°C&period; Upon reconstitution of the peptide it should be stored at 4°C between 2-21 days and for future use below -18°C&period;

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pentadecapeptide BPC 157

2mg&sol;vial

176-191

2mg&sol;vial

Triptorelin

2mg&sol;vial

Tesamorelin

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Gonadorelin

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Gonadorelin

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