Molecular signatures associated with obesity and risk of diabetes in Pakistan

US Partner: Mohammed Ali, Emory University

Pakistan Partner: Muhammad Khadir, Aga Khan University

Project summary Obesity is strongly associated with type 2 diabetes (T2DM); however, non-obese Pakistani people also develop the disease in large numbers. The need for innovative strategies to tackle T2DM is greater than ever; in Pakistan, T2DM burdens are particularly high, affecting one in five adults. This study will build on a cohort study in Karachi, Pakistan to identify early biomarkers that can predict early risk of T2DM in South Asians. It will also identify interactions between dietary and genetic factors. By employing a genome-wide association analyses approach and targeted metabolomics, this project will enable the design of intervention strategies, ultimately leading to more personalized T2DM prevention and management.