AIM: Hospital inpatient care for children with diabetes is frequently mentioned by parents as unsatisfactory. The aim of this study was to examine the reasons for inpatient admission of children with diabetes and to understand patient and carer experience in order to improve services. METHODS: Questionnaires were given to medical ...

Significance: This review relates to artificial redox-driven molecular devices. The advantages of using very simple chemical building blocks for the bottom-up design of nano-leveled functional motors and the importance of the unidirectionality of a switching process for the development of redox-driven molecular motors are discussed. Furthermore, the crucial difference between ...

Objective. Aberrant splicing is one of the most significant components generating functional diversity in many pathological conditions. The objective of this study was to analyse the mutations or aberrant splicing of A20 transcript, the region encompassing the ovarian tumour (OTU) domain [which is functionally important as an inhibitor of nuclear ...

ACCESSIBLE SUMMARY: Weight gain is a known, predictable side-effect of second-generation antipsychotic drugs. Study participants reported struggling to manage the insatiable appetite and weight gained associated with the drugs. Cessation of prescribed medication was considered by most as a way of managing the weight gain associated with the drugs. ABSTRACT: ...

OBJECTIVE:To test the hypothesis that the weight-for-stature (WFS) and BMI methods are not equivalent in determining expected body weight (EBW) in adolescents with eating disorders and to determine the sensitivity, specificity, and positive predictive value of each method to detect those <75% EBW. We hypothesized that differences in EBW would ...

Significance: Control over reversible changes to molecular structure forms the basis for artificial molecular machines that could eventually lead to the development of molecule based nanotechnology. Recent Advances: Particular applications in information storage and processing could emerge where the structural rearrangements give rise to bistability and molecular hysteresis effects. Critical ...

Iron-oxophlorin is an intermediate in heme degradation, and the metal oxidation number can alter spin, electron distribution, and the reactivity of the metal and the oxophlorin ring. The role of electron transfer in the structure and reactivity of [(Py)(2)Fe(III)(PO)] (PO is the oxophlorin trianion) in different redox states has been ...

Several fuel spills have occurred on subantarctic Macquarie Island (54°30' S 158°57' E) associated with storing fuel and generating power for the Island's research station. The Australian Antarctic Division began full-scale, on-site remediation of these sites in 2009. To develop appropriate target concentrations for remediation, acute and chronic tests were ...

Prebiotics constitute emerging tools to alleviate immune pathologies. This study aimed to evaluate the effect of prebiotic exposure during perinatal and post-weaning periods on immune and gut regulations. Mice were fed either a galactooligosaccharides/inulin prebiotic mix-enriched diet or a control diet during the perinatal and/or post-weaning periods. Biomarkers related to ...

INTRODUCTION: Clinical outcomes in pediatric anesthesia have improved significantly over the last 20-30 years but unexpected laryngospasm that is difficult to treat can still result in patient morbidity, increased postoperative medical management and unnecessary hospital admission. The incidence of laryngospasm in pediatric anesthesia is difficult to determine with incidences from 0.9% ...

BACKGROUND: Since the 1970s red blood cells (RBCs) have had a rated shelf life of 42 days. Recently, studies have suggested poorer patient outcomes when older blood is transfused. However, shortening the shelf life of RBCs may increase costs and lead to greater instances of outdates and shortages. STUDY DESIGN ...

The mule duck, an interspecific hybrid obtained by crossing common duck (Anas Platyrhynchos) females with Muscovy (Cairina moschata) drakes, is widely used for fatty liver production. The purpose of the present study was to detect and map single and pleiotropic QTL that segregate in the common duck species, and influence ...

Global climate change (GCC) is likely to alter the degree of human exposure to pollutants and the response of human populations to these exposures, meaning that risks of pollutants could change in the future. The present study, therefore, explores how GCC might affect the different steps in the pathway from ...

This report discusses the diagnosis and treatment of afibrinogenemia in a Chihuahua. Prolongations of prothrombin time (PT), activated partial thromboplastin time (aPTT), and thrombin clotting time (TCT) together with fibrinogen assay results of either no or trace amounts of fibrinogen support a diagnosis of afibrinogenemia. Differential diagnoses include common coagulopathies, ...

Abstract Purpose: Since the presence of keratinized gingiva is so important for peri-implant outcome, the aim of this study is to describe a partial thickness flap design to increase the amount of keratinized peri-implant tissue as well as its thickness.Materials and Methods: A total of 131 implants were placed: 103 ...

Demographic and Health Surveys (DHS) are comparable nationally representative household surveys that have been conducted in more than 85 countries worldwide since 1984. The DHS were initially designed to expand on demographic, fertility and family planning data collected in the World Fertility Surveys and Contraceptive Prevalence Surveys, and continue to ...

There is no doubt that the European Association for Cardio-Thoracic Surgery is a success story. In 2011, we celebrated the 25th anniversary of this professional organization. In 2012, we will celebrate the 25th anniversary of the European Journal of Cardio-Thoracic Surgery. In addition, two other journals have been initiated, Interactive ...

Experimental proof is presented for a hitherto undetected solid-state reaction between the solar cell material Cu(2)ZnSn(S,Se)(4) (CZTS(e)) and the standard metallic back contact, molybdenum (Mo). Annealing experiments combined with Raman and TEM studies show that this aggressive reaction causes formation of MoS(2) and secondary phases at the CZTS|Mo interface during ...

PURPOSE: The prognosis for patients with glioblastoma multiforme (GBM) remains extremely poor despite recent treatment advances. There is an urgent need to develop novel therapies for this disease.EXPERIMENTAL DESIGN: We used the implantable GL261 murine glioma model to investigate the therapeutic potential of a vaccine consisting of intravenous injection of ...

Chronic obstructive pulmonary disease (COPD) is a serious global health burden. Comprehensive management of COPD includes both pharmacologic and non-pharmacologic interventions aimed at improving disease-related functional capacity, health-related quality of life, and survival. The primary medications used for treatment of COPD are inhaled bronchodilator drugs which are delivered directly to ...

Patients with renal cell carcinoma (RCC) who are black tend to have poorer prognosis than similar patients who are white. This study examined whether the racial disparity in RCC patient survival varies by demographic and clinical characteristics. Nearly 40,000 patients (4359 black and 34,991 white) diagnosed with invasive RCC from ...

This is a response to the comment by Anzo and Okada on our recent article published in Analytical Chemistry. Anzo and Okada estimated our experimental results for proton distribution in a 400 nm nanochannel based on the Poisson-Boltzmann theory with the Gouy-Chapman model. We consider that their comment is very ...

Halogen bonding has been known in material science for decades, but until recently, halogen bonds in protein-ligand interactions were largely the result of serendipitous discovery rather than rational design. In this perspective, we provide insights into the phenomenon of halogen bonding, with special focus on its role in drug discovery. ...

Abstract Abstract: Modification of sinus floor and providing adequate space for implant surgery by orthodontic tooth movement might be a predictable treatment procedure. In this case, implant therapy was performed by providing adequate space with orthodontic tooth movement in a patient has inadequate alveol height at posterior maxilla.Method: A 54 ...

The proteasome is the primary site for protein degradation in mammalian cells, and proteasome inhibitors have been invaluable tools in clarifying its cellular functions. The anticancer agent bortezomib inhibits the major peptidase sites in the proteasome's 20S core particle. It is a "blockbuster drug" that has led to dramatic improvements ...

Totipotent embryonic stem cell lines have not been established from ungulates; however, we have developed a somatic stem cell line from the in vitro culture of pig epiblast cells. The cell line, ARS-PICM-19, was isolated via colony-cloning and was found to spontaneously differentiate into hepatic parenchymal epithelial cell types, namely, ...

ABSTRACT A patient with a history of Parkinson's disease and severe bilateral peripheral vision loss due to vitreous hemorrhages had complex visual hallucinations that persisted for three days and appeared every morning on awakening. The persistent nature of these hallucinations, the patient's preserved insight, and the presence of severe visual ...

Novel eggroll-like CaSnO(3) nanotubes have been prepared by a single spinneret electrospinning method followed by calcination in air for the first time. The electrospun sample as a lithium-ion battery electrode material exhibited improved cycling stability and rate capability by virtue of the high surface area and unique hollow interior structure, ...

Highly specific antibodies to phosphoepitopes are valuable tools to study phosphorylation in disease states, but their discovery is largely empirical, and the molecular mechanisms mediating phosphospecific binding are poorly understood. Here, we report the generation and characterization of extremely specific recombinant chicken antibodies to three phosphoepitopes on the Alzheimer disease-associated ...

A new approach to the tetracycline core structure is presented. The pivotal intermediate is identified as macrocycle III. The two interior bonds (C4a-C12a and C5a-C11a) are to be constructed through sequential transannular Michael additions (III-II) and compression-promoted transannular isoxazole alkylations from intermediate II.

We report on graphene-passivated ferromagnetic electrodes (GPFE) for spin devices. GPFE are shown to act as spin-polarized oxidation-resistant electrodes. The direct coating of nickel with few layer graphene through a readily scalable chemical vapour deposition (CVD) process allows the preservation of an unoxidized nickel surface upon air exposure. Fabrication and ...

Takayasu arteritis (TA) in the child remains a therapeutic challenge because corticosteroids and conventional immunosuppressive agents are not always safe or efficacious. The complex formed by interleukin-6 (IL-6) and soluble IL-6 receptor appears to play a pivotal role in the pathogenesis of TA. We describe a favorable response to the ...

The first computational study of the folding and dynamics of a hydrophobic β-hairpin containing a central heterochiral diproline segment is reported. Linear hydrophobic sequences containing centrally positioned diproline motifs, heterochiral (DL/LD) and homochiral (LL/DD)), are investigated for their ability to form β-hairpins. Heterochiral diproline motifs (LD/DL) reveal the formation of ...

ACCESSIBLE SUMMARY: Mental health nursing is in a process of redefining itself and being asked to promote mental health to a wider public, and it therefore needs to engage with ideas new to nursing. Jacques Lacan's ideas appear of particular relevance to those interested in mental health. In particular, a ...

Purpose There may be an increase in the risk of atrial arrhythmia due to left atrial enlargement and the influence on conduction system in acute rheumatic fever. The aim of this study is to investigate atrial electromechanical delay and P-wave dispersion in patients with acute rheumatic fever. Patients A total ...

Intracellular resistance (Ri), a raw measure of bioimpedance spectroscopy (BIS), has been suggested for assessment of muscle health. The associations of repeated BIS measurements with functioning and nutritional status were investigated in nursing home residents suffering from poor health and disabilities. A total of 106 nursing home residents (age 83±8 ...

The article "The ecological risk assessment of atrazine in North American surface waters" [1] is one of the few among the 100 most cited articles in Environmental Toxicology and Chemistry to specifically address risk and/or assessment of risk, and it was the first to use probabilistic approaches for a pesticide. ...

Intracellular de novo protein folding is assisted by cellular networks of molecular chaperones. In Escherichia coli, cooperation between the chaperones trigger factor (TF) and DnaK is central to this process. Accordingly, the simultaneous deletion of both chaperone-encoding genes leads to severe growth and protein folding defects. Herein, we took advantage ...

Background: The implantation of endoprostheses is an established procedure in orthopaedic and trauma surgery. However, the techniques are often associated with a high risk of postinterventional infections and wound healing disorders that can result in loss of the prosthesis or the limb - most likely based on an insufficient debridement ...