Check the appropriate box below if the
Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions
(see General Instruction A.2. below):

¨

Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)

On October 1, 2012, Ronald W. Rudolph resigned
as Executive Vice President of Finance and Chief Financial Officer of Targeted Medical Pharma, Inc. (the “Company) to pursue
other opportunities. Mr. Rudolph will continue on with the Company to provide assistance in the completion of the Quarterly Report
on Form 10-Q relating to the Company’s third fiscal quarter ended September 30, 2012.

SIGNATURES

Pursuant to the requirements of the Securities
Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.