Very potent polymyxin antibiotic. Has only one amino acid difference compared to polymyxin B. Antimicrobial. Targets the lipopolysaccharide (LPS) of the outer membrane of Gram-negative bacteria. Competitively displaces divalent cations (Ca2+ and Mg2+) from the negatively-charged phosphate groups LPS, causing disruption of the membrane. This increases the permeability of the cell envelope, leakage of cell contents, leading to apoptosis and cell death. Used against multidrug-resistant Gram-negative bacterial infections.

Catalog #

044677

Storage and Stability

Short-term Storage: +4°C

Long-term Storage: +4°C

Stable for at least 2 years after receipt when stored at +4°C.

CAS Number

1264-72-8

Molecular Formula

2(C52H98N16O13) . 5(H2SO4)

Molecular Weight

2801.7

Purity

Mixture (primarly colistin A and B).

Important Note

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.