1972 — For the first time in history, the major leagues failed to open on schedule because

1972 — For the first time in history, the major leagues failed to open on schedule because of a player strike, which started on April 1. The traditional season opener between Houston and Cincinnati was canceled and a total of 86 games were lost before the strike was settled.

1973 — Ron Blomberg of the New York Yankees became the first major league designated hitter. With the bases loaded in the first inning, he was walked by pitcher Luis Tiant, but the Red Sox won, 15–5.

1974 — Due to renovations at Yankee Stadium, the New York Yankees' home opener took place at Shea Stadium. It was their first home game outside Yankee Stadium since 1922.

1977 — The Seattle Mariners played their first regular–season game and lost 7–0 to the Angels at the Kingdome.