To determine how the acute PBMC responses are altered by gender, pubertal status, body composition (measured by whole-body and regional DEXA), and fitness (measured by progressive cycle ergometry and gas exchange).

To determine the relationship in healthy children and adolescents among acute PBMC responses to exercise, biochemical precursors of the metabolic syndrome (insulin, glucose, lipids), and the balance of the TH1/TH2 immune response.

Study Type ICMJE

Observational

Study Design ICMJE

Observational Model: CohortTime Perspective: Cross-Sectional

Target Follow-Up Duration

Not Provided

Biospecimen

Retention: Samples With DNA

Description:

Peripheral blood mononuclear cells, plasma, serum, mRNA

Sampling Method

Non-Probability Sample

Study Population

Early and late pubertal boys and girls recruited from Orange County, CA

Condition ICMJE

Physical Fitness

Obesity

Child Development

Growth

Intervention ICMJE

Not Provided

Study Group/Cohort (s)

Children

Early and late pubertal girls and boys

Publications *

Not Provided

* Includes publications given by the data provider as well as publications
identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.

Recruitment Information

Recruitment Status ICMJE

Unknown status

Estimated Enrollment ICMJE

160

Estimated Completion Date

February 2015

Estimated Primary Completion Date

January 2015 (final data collection date for primary outcome measure)

Eligibility Criteria ICMJE

Inclusion Criteria:

appropriate Tanner Stage

No evidence of disease or disability

Exclusion Criteria:

no use of antiinflammatory medications, alcohol, illegal drugs or bronchodilators

elite children participating in extensive exercise or dance programs

pregnant

Gender

Both

Ages

8 Years to 18 Years (Child, Adult)

Accepts Healthy Volunteers

Yes

Contacts ICMJE

Contact information is only displayed when the study is recruiting subjects