Purpose:
To compare anxiety and depression states of patients between with moderate and with advanced stage of retinitis pigmentosa (RP).

Methods:
Comparative case series. Advanced stage RP was defined as the one with visual field area smaller than a 10-degree diameter in the Goldmann V-4 target and moderate stage RP was defined as the one with visual field area larger than a 10-degree diameter in the Goldmann V-4 target. Thirty-two patients with advanced stage RP and 15 patients with moderate stage RP were evaluated. Anxiety or depression states was evaluated using the hospital anxiety and depression scale questionnaire (HADS),that consists of the anxiety (HADS-A) and depression (HADS-D) scales. Both scales in advanced RP patients were compared with the moderate RP patients. Relationship between the HADS-A and HADS-D scores of RP patients was assessed using Spearman’s correlation analysis. This study was approved ethics committee of both institutes. Registration number UMIN-000014959

Results:
There was no significant difference in the HADS-A and HADS-D score between the advanced and the moderate RP patients (P=0.60, 0.91). There was significant association between the HADS-A and HADS-D score in the advanced, moderate and all RP patients (P<0.05).

Conclusions:
The anxiety and depressive state were not significantly different from patients with advanced and moderate stage of RP. The anxiety state was significantly correlated with the depression state in RP patients.