Ruffelle was Les Miserables' original 'Eponine' on the West End, and is featured in the cast of the upcoming film adaptation of the musical, set for release on Christmas Day. Ruffelle has also appeared on the West End in Children of Eden, Apples, Mack & Mabel, Starlight Express and more.

Les Miserables originally opened in London at the Barbican Theatre on 8 October 1985, transferred to the Palace Theatre on 4 December 1985 and moved to its current home at the Queen's Theatreon 3 April 2004. When LES MISERABLES celebrated its 21st London birthday on 8 October 2006, it became the World's Longest Running Musical, surpassing the record previously held by "Cats" in London's West End. In January 2010, The West End production broke another record by celebrating its historic 10,000th performance.