We recommend that future studies attempting to optimise duration of antibiotic therapy utilising these biomarkers in septic critically ill patients will need to consider large sample sizes to account for the heterogeneity of patients and establish unambiguous clinical and microbiological definitions of infection and treatment efficacy.

IDSA guidelines recommend antibiotic therapy for all cases of ABRS: The IDSA guidelines recommend antibiotic therapy in the management of all cases of suspected acute bacterial rhinosinusitis in adults.

In order to appropriately cover a wide variety of increasingly resistant pathogens, broad-spectrum antibiotic therapy is frequently administered when blood-culture results are reported as positive and an infection is suspected.

The 189 women who received antibiotic therapy during follow-up had a total of 54 episodes of vulvovaginal candidiasis treated with antifungal therapy The 127 women who had not received antibiotic therapy received 25 courses of antifungal treatment for vulvovaginal candidiasis.

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