Purpose: To improve functioning among older adults with Alzheimer's disease by comparing a control group receiving best practices primary care with an intervention group receiving best practice primary care plus a home-based occupational therapy intervention.

Purpose: To test whether an anti-amyloid investigational drug, solanezumab, can slow memory and cognitive decline in older individuals who do not yet show symptoms of Alzheimer's disease cognitive impairment or dementia.

Purpose: To determine the value of arterial spin labeling magnetic resonance imaging, a measure of blood flow to the brain, in finding the cause of cognitive decline in people with mild cognitive impairment.

Purpose: To find out if atomoxetine causes a change in the biomarkers (substances that may indicate the presence of a disease) in the cerebrospinal fluid of people diagnosed with mild cognitive impairment.

Purpose: To determine if Fruitflow-II (a tomato extract), resveratrol (a compound found in some foods), alone or in combination, can effectively treat memory problems in older adults with memory impairment.

Purpose: To determine whether an aerobic exercise program will alter markers of immune cell aging, improve blood pressure, and decrease psychological distress in caregivers of people with Alzheimer's disease.

Purpose: To determine whether a combined intervention of a nighttime home monitoring system and cognitive-behavioral therapy for insomnia is effective in improving sleep in dementia caregivers who arise at night.

Purpose: To determine whether positron emission tomography (PET) scanning can help distinguish patients with early Alzheimer's changes in their brains from those having other causes of cognitive impairment more accurately than current clinical practices.

Purpose: To test the efficacy of the Tailored Activity Program, a patient-centric intervention designed to reduce the burden of neuropsychiatric symptoms in veterans with dementia who live at home with family caregivers.