Summariesfor PMS2 gene

This gene is one of the PMS2 gene family members found in clusters on chromosome 7. The product of this gene is

involved in DNA mismatch repair. It forms a heterodimer with MLH1 and this complex interacts with other complexes

bound to mismatched bases. Mutations in this gene are associated with hereditary nonpolyposis colorectal cancer,

Turcot syndrome, and are a cause of supratentorial primitive neuroectodermal tumors. Alternatively spliced

transcript variants have been observed for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for PMS2 Gene:

PMS2 (PMS2 postmeiotic segregation increased 2 (S. cerevisiae)) is a protein-coding gene. Diseases associated with PMS2 include turcot syndrome, and pms2-related turcot syndrome. GO annotations related to this gene include ATPase activity and endonuclease activity. An important paralog of this gene is PMS1.