Cleo (Corrinne Marchand) is a beautiful, spoiled, self-obsessed pop singer. As the film opens, she is having her fortune told by a tarot reader, who is startled to discover death and cancer in the singer's immediate future. Cleo is quite upset, as she is waiting to meet with a doctor to discuss the results of a medical examination. The remainder of the 90-minute-film chronicles Cleo's afternoon, from the time that she leaves the tarot reader until her appointment at the hospital two hours later. We see her return home to her fashionably minimalist apartment, where she tends her kittens, does her exercises, and meets with her songwriters. Exasperated by the jokes of her friends and by her own worries, she sets off alone through the streets, cafes, and parks of Paris, running errands with a friend and meeting a young soldier, Antoine, who is to ship off for the battlefields of Algeria on the following morning.

<![CDATA[<i>]]>Cléo de 5 à 7<![CDATA[</i>]]> is very much a film about perception — about looking and being looked at, and the warped sensibilities formed when worth is based solely on appearances.