4DP Candidate, Department of Pharmacology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

چکیده [English]

Backgrounds Drug resistance in zoonotic bacterial pathogens is a serious risk, which threatens the prosperity and profitability of livestock industry and also public health. To confront this threat, it is necessary to determine and use novel antibacterial compounds on the resistant bacteria. Thiazole and imidazole derivatives are the novel antibacterial agents; the current study aimed at assessing the antibacterial effect of 1 thiazole derivative and 2 imidazole derivatives on Rhodococcus equi, Brucella abortus, and Pasteurella multocida.Methods & Materials To investigate the antibacterial effect of selected antibiotics, the disk diffusion method was used and the diameter of growth inhibition zone was also measured; the serial dilution method in micro-plates was also employed to assess the minimum inhibitory concentrations (MICs).Results The results showed that none of the thiazole and imidazole derivatives had inhibitory effect on B. aabortus. Imidazole derivatives also lacked any inhibitory clue on the tested bacteria. The inhibitory effect was only observed in the thiazole derivative with MICs of 128 and 16 µg/mL, and growth inhibition zone diameter of 19.3±0.2 and 28.1±0.3 mm on R. equi and P. multocida, respectively.Conclusion The inhibitory effect of thiazole derivative was observed on R. equi and P. multocidawas. This antibiotic also showed more inhibitory effects on P. multocida.