powerfull vs Bulk 1-carboxy-2-amino-3-pyrobenzo

Maybe because doctors need to study disease or surgery. I'm sure they have time to read the recent issue of MD or FLEX. Such a whack arguement.

You should order steamed vegetables and walk before buying a weight loss supplement...makes perfect unsarcastic sense.

But You think PA knows his chemicals because you do not know any better nor should you. I'm would not expect an accountant to understand organic bio chemistry. In the eyes of the consumer, PA is the "Sh*t" becuase he designed a few steroids and made Costas live.

When I talk Doctorates degree in India, I'm speaking in Chemistry.

Applied Nutriceuticals RepresentativeBetter Results Through ScienceSuccess occurs when everything you have is APPLIED.
Have you heard about N.O. Uptake? ;-)

Maybe because doctors need to study disease or surgery. I'm sure they have time to read the recent issue of MD or FLEX. Such a whack arguement.

You should order steamed vegetables and walk before buying a weight loss supplement...makes perfect unsarcastic sense.

But You think PA knows his chemicals because you do not know any better nor should you. I'm would not expect an accountant to understand organic bio chemistry. In the eyes of the consumer, PA is the "Sh*t" becuase he designed a few steroids and made Costas live.

When I talk Doctorates degree in India, I'm speaking in Chemistry.

nothing i have ever seen you write, or written on behalf of your company, has demonstrated any technical competence in chemistry

You also have to recognize that his consumers don't have any technical competence in chemistry either. What's the point in talking something up in terms which the person buying it wouldn't understand?

i wasn't just talking about the advertisements but even if you are talking about the advertisements how do you defend him saying that L-dopa does not cross the blood brain barrier? Its as though he did not understand how the stuff functions in the first place yet he is claiming to sell some technologically advanced form of it

I still have never gotten "Throbbing, Rock-Hard Erections That Last" either btw

I did get that effect from the old powerfull.
And that at only 2 caps twice a day.
And it did give me better rest becasue I work graveyard and on that old pfull I could sleep a straight eight hours in the daytime.
Have not tried the new formula yet.

i wasn't just talking about the advertisements but even if you are talking about the advertisements how do you defend him saying that L-dopa does not cross the blood brain barrier? Its as though he did not understand how the stuff functions in the first place yet he is claiming to sell some technologically advanced form of it

indians are an incredible pain in the ass to do business with. i don't mean that as a racist comment. its a cultural comment

not that this has anything to do with this thread

my mother was an indian, watch what you say or you'll have a lawsuit on your hands

i think it's you who's the pain in the rectum

09-09-2007, 01:47 AM

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Originally Posted by Patrick Arnold

indians are an incredible pain in the ass to do business with. i don't mean that as a racist comment. its a cultural comment

not that this has anything to do with this thread

You should said that **** on costas. Can I quote you in my next write up..serious question.

09-09-2007, 01:52 AM

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Originally Posted by Patrick Arnold

i wasn't just talking about the advertisements but even if you are talking about the advertisements how do you defend him saying that L-dopa does not cross the blood brain barrier? Its as though he did not understand how the stuff functions in the first place yet he is claiming to sell some technologically advanced form of it

The problem is that other tissus like muscle absorb l-dopa (I'm not sure why or what its used for in other tissues) before sufficient amounts can reach the brain.

Well they sent over the study that showed quercertin did not increase resveratrols bio-availability, but you claim it dose. You seem to avoid the direct questions and attack others.

there's been a few studies which have shown quercetin to inhibit the estrone sulfase enzyme. There's also been many studies showing that resveratrol is readily suflonated by this enzyme. I would imagine this is what PA is going off of.

There's also been thought that the resveratrol metabolites might still be active to some degree.

Another key word to note is "showed". You can "show" but that doesn't necessarily "prove".

I'm not trying to take sides. USPLabs and ErgoPharm are both great companies and I enjoy their products. This thread is starting to turn into a
"Your product sucks."
"Oh yeah, well your product sucks worse." type of thread.

I mean, I don't really understand what (if anything) you guys are trying to prove at this point, but it just makes both your companies look bad.

there's been a few studies which have shown quercetin to inhibit the estrone sulfase enzyme. There's also been many studies showing that resveratrol is readily suflonated by this enzyme. I would imagine this is what PA is going off of.

1. Resveratrol, a polyphenolic compound present in grape and wine, has beneficial effects against cancer and protective effects on the cardiovascular system. Resveratrol is sulphated, and the hepatic and duodenal sulphation might limit the bioavailability of this compound. The aim of this study was to see whether natural flavonoids present in wine, fruits and vegetables inhibit the sulphation of resveratrol in the human liver and duodenum. 2. In the liver, IC50 for the inhibition of resveratrol sulphation was 12+/-2 pM (quercetin), 1.0+/-0.04 microM (fisetin), 1.4+/-0.1 microM (myricetin), 2.2+/-0.1 microM (kaempferol) and 2.8+/-0.2 microM (apigenin). Similarly, in the duodenum, IC50 was 15+/-2 pM (quercetin), 1.3+/-0.1 microM (apigenin), 1.3+/-0.5 microM (fisetin), 2.3+/-0.1 microM (kaempferol) and 2.5+/-0.3 microM (myricetin). 3. The type of inhibition of quercetin on resveratrol sulphation was studied in three liver samples and was determined to be non-competitive and mixed in nature. Km (mean+/-SD; microM) was 0.23+/-0.07 (control), 0.40+/-0.08 (5 pM quercetin) and 0.56+/-0.09 (10 pM quercetin). Vmax (mean+/-SD; pmol min(-1) x mg(-1)) was 99+/-11 (control), 73+/-15 (5 pM quercetin) and 57 +/- 10 (10 pM quercetin). Kj and Kies estimates (mean+/-SD) were 3.7+/-1.8 pM and 12.1+/-1.7 pM respectively (p = 0.010). 4. Chrysin was a substrate for the sulphotransferase(s) and an assay was developed for measuring the chrysin sulphation rate in human liver. The enzyme followed Michaelis-Menten kinetics and Km and Vmax (mean+/-SD) measured in four livers were 0.29+/-0.07 microM and 43.1+/-1.9 pmol x min(-1) x mg(-1) respectively. 5. Catechin was neither an inhibitor of resveratrol sulphation nor a substrate of sulphotransferase. 6. These results are consistent with the view that many, but not all, flavonoids inhibit the hepatic and duodenal sulphation of resveratrol, and such inhibition might improve the bioavailability of this compound.

If L-Dopa stimulates dopamine (sometimes dubbed as PIH, or prolactin inhibiting hormone), if it is taken before bed in conjunction with GHB, which is shown to inhibit dopamine pathways and increases prolactin secretion... Will L-Dopa stimulate enough dopamine to stop the prolactin from negating the HGH benefits from GHB?