We noted you are experiencing viewing problems

Check with your IT department that JWPlatform, JWPlayer and Amazon AWS & CloudFront
are not being blocked by your network.
The relevant domains are *.jwplatform.com,
*.jwpsrv.com, *.jwpcdn.com,
jwpltx.com, jwpsrv.a.ssl.fastly.net,
*.amazonaws.com and *.cloudfront.net.
The relevant ports are 80 and 443.

Transcript

Choose Transcript Language:

0:00

Hello, my name is Ron Fouchier,Virologist at Erasmus Medical Centre in Rotterdam.In this presentation, I will discussthe discovery and characterization of four viral pathogens thatare associated with respiratory illnesses inhumans and that have been described since 2001.The pathogens are first a paramyxovirus namedHuman metapneumovirus, two human coronaviruses,NL63 and HKU1, and a parvovirus named Human bocavirus.

0:29

It is well known that a wide range ofpathogens can cause respiratory tract illnesses in humans.Viruses are the most frequently detected causative agents,in particular, 40 acute respiratory tract illnesses.As an example, this slide shows the result of diagnostic tests for 540 patientswith respiratory problems visitingtheir general practitioner about 10 years ago in the Netherlands.Several notorious pathogens were circulating this winter season with enteroviruses,respiratory syncytial virus, influenza A and B virus,and rhinoviruses as the most frequently detected viral pathogens.The reason why I put this slide up is not so much the positive diagnostic results,which can vary considerably between studies,but to point out that in a significant proportion of the patients,in this case 36 percent,no known pathogen could be detected.This proportion of respiratory tract illnesses with unknown etiology is highly variable,for instance, for different patient populations, locations and timing.But in most studies like this one,an etiological agent cannot be identified ina large proportion of patients under investigation.I will discuss some of the viral pathogens that have been discovered inthe past six or seven years by research groups attemptingto reduce this proportion of illnesses with unknown etiology.In 2001, a study by the Van der Hoek and others in the Netherlands described