London: A non-invasive approach, that uses musical tones to balance brain activity, can 'reset' the brain and effectively reduce insomnia, researchers at Wake Forest Baptist Medical Center have found.Charles H. Tegeler, M.D., professor of neurology at Wake Forest Baptist and principal investigator of the study explained how the technology works.

"The human brain is made up of the left and right hemispheres that work together as parallel processors. When a person undergoes trauma or a major stressor, their autonomic survival responses kick in and the brain can become unbalanced. If those imbalances persist, symptoms such as insomnia can result. Our study looked at a new technology that is intended to facilitate greater balance and harmony in brain frequencies, which may result in improved symptoms," he said.

The non-invasive procedure uses a system that is designed to reflect the brain's frequencies back to itself using musical tones. Resonance between the musical tones and the electrical energy in a person's brain can bring balance to the two hemispheres of the brain.

Study results were based on a change in the Insomnia Severity Index (ISI), which measures the severity of sleep disruption using a zero-to-28 point scale; the median ISI for study participants was between 18.7 and 18.9, which is considered moderate-to-severe insomnia.

Researchers found that the HIRREM group had a 10.3 point drop in ISI, improved insomnia symptoms and, clinically moved into a category of 'no insomnia' or 'sub-threshold insomnia'.

The control subjects, who continued their existing insomnia treatment without HIRREM, showed no change in ISI. However, when the crossover control group received HIRREM therapy, the results were indistinguishable from those of the original HIRREM group.

Study participants randomized to HIRREM underwent eight to 12 sessions that each lasted between 60-90 minutes. The sessions involved reclining in a zero gravity chair and placing sensors over numerous locations on both sides of the scalp.

A musical tone, determined by a mathematic algorithm and based on the dominant frequency in a floating middle range of the participant's EEG frequencies, was played back to the participant through ear buds.

Resonance between musical tones and oscillating brain circuits is designed to allow the brain to auto-calibrate, moving towards better balance, with associated improvement in symptoms.

Although the researchers believe that the degree of improvement and length of time it persisted (for four weeks after the last session) suggests real change through HIRREM, Tegeler is planning a larger clinical trial using a sham placebo, to confirm the HIRREM effect and further explore the technology.

The study was published online in October, advance of print, in the journal Brain and Behavior.