The Toyota Isis is a seven-seat large MPV manufactured by Kanto Auto Works under contract for Japanese automaker Toyota. It is sold in Japan and was launched in September 2004. It features sliding doors and is available with either front- or four-wheel drive and straight-4 1.8- and 2.0-litre gasoline engines. It competes in Japan with the Honda Stream and the Nissan Lafesta.

Toyota Isis Platana

Isis with doors open

The Isis uses a unique approach to the sliding doors in that the front passenger door and the rear passenger sliding door interlock when closed, instead of having a doorjamb that the doors attach to. Toyota calls this on the Japanese Wikipedia article "Panoramic Door". This door system is used only on the passenger side. The doors on the driver's side attach with a conventional doorjamb. The front passenger seat can be folded flat upon itself and then tilted forward to further provide passenger access. The doors also interlock with the top and bottom door openings so that both doors can be opened independently of each other. This door feature was first used by Toyota on the Toyota Raum. This door approach is also used on the U.S.-spec 2000–2006 Toyota Tundra Extra Cab as well as the Ford B-Max. This type of door was first used on the Nissan Prairie in 1981. When the terrorist group ISIS emerged in 2014, Toyota was criticised for inadvertently supplying Isis with trucks and was urged to change the name of the MPV.

For model year 2007 on Japanese models only, G-BOOK, a subscription telematics service is offered as an option.