Nod2 Receptor Role in TNF-α Secretion Response to Pseudomonas Aeruginosa

View/Open

Date

Author

Metadata

Abstract

•Mechanisms of the innate immune response serve as the
first line of defense against infection and coordinate the
adaptive immune response
•Pathogen Associated Molecular Patterns (PAMPs) are
detected by a group of receptors called Pattern Recognition
Receptors (PRRs) that respond by upregulating secretion of
pro-inflammatory cytokines and chemokines such as TNF-α
and KC (human IL-8)
•PRR group members such as Toll-like Receptors (TLRs) and
Nod-like Receptors NLRs detect the presence of PAMPs
•The receptors relevant to this study are sensitive to different
molecules associated with bacterial cell walls
•TLR4: Type I transmembrane receptor for
Lipopolysaccharide (LPS), a major component of gramnegative
bacterial cell walls
•Nod1: cytosolic detection of meso-Diaminopimelic Acid
(meso-DAP) a residue found in the cell walls of most gram
negative bacteria
•Nod2: cytosolic detection of Muramyl Dipeptide (MDP) a
part of the peptidoglycan (PGN) molecule found on both
gram-positive and gram-negative bacteria
•Pseudomonas aeruginosa is an opportunistic gram-negative
bacteria that causes severe infections in
immunocompromised patients