Gastroparesis, also called delayed gastric emptying, is a medical condition consisting of a paresis (partial paralysis) of the stomach, resulting in food remaining in the stomach for a longer time than normal.

A study showed that "Patients with cholecystectomy had more comorbidities, particularly chronic fatigue syndrome, fibromyalgia, depression, and anxiety."

What is the biochemistry behind delayed gastric emptying? Could TRPA1 be involved?

Serotonin (5-hydroxytryptamine (5-HT) is a neurostransmitter. Biochemically derived from tryptophan, serotonin is primarily found in the gastrointestinal tract. Approximately 90% of the human body's total serotonin is located in the enterochromaffin cells in the alimentary canal (gut), where it is used to regulate intestinal movements.

TRPA1 is highly expressed in human and rat enterochromaffin (EC) cells, and TRPA1 agonists enhance the release of serotonin from EC cells in vitro. Reference