Alzheimer's disease

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Abstract

Despite progress made in laboratory methods, genetic studies, and modern neuroimaging, the diagnosis of diseases that cause dementia makes difficulties. The review presents an update on the epidemiology, risk factors, pathogenesis, clinical presentation, diagnosis, and treatment of Alzheimer's disease (AD). It discusses the issues of symptomatic and pathogenetic treatments and combination therapy for AD. The efficacy of memantine (akatinol memantine) and the expediency of its use at different stages of the disease in patients with AD are noted. Non-pharmacological treatments for this disease, including physical activity and cognitive training, are considered.

30. Dubois B, Hampel H, Feldman HH, et al. Proceedings of the Meeting of the International Working Group (IWG) and the American Alzheimer's Association on «The Preclinical State of AD»; July 23, 2015; Washington DC, USA. Alzheimers Dement. 2016;12:292-323. doi: 10.1016/j.jalz.2016.02.002

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