2020: After the death of founder Eldon Tyrell, the Tyrell Corporation rushes a new line of Nexus 8 Replicants onto the market for use Off-world. Unlike previous Nexus models, built with 4-year lifespans, the Nexus 8s have open-ended lifespans, as well as ocular implants for easy identification

2022: The Blackout. An EMP of unknown origin detonates somewhere in the West Coast. Cities are shut down for weeks. Electronic data is corrupted or destroyed over most of the United States. Finance and trade markets crash worldwide. Food supplies become dire. Theories spread as to the cause of the Blackout; none are proven. The most popular blame Replicants.

2023: Replicant Prohibition. The governing authorities legislate an indefinite "prohibition" on replicant production. Nexus 6 models are now all decommissioned due to their programmed 4-year lifespans. Surviving Nexus 8 models are to be retired. Those that can, go into hiding.

2025: Idealistic scientist Niander Wallace pioneers advancements in genetically modified food and shares his patents for free, marking an end to a global crisis. His company, Wallace Corporation, E&C, expands across the globe — and into the Off-world colonies.

2049: When we return to Los Angeles, 30 years after the original movie, climate change has caused the sea level to rise dramatically. A massive Sea Wall has been built along the Sepulveda Pass to protect the Los Angeles basin. Los Angeles is even more uninhabitable than before and filled with poverty and sickness. Humans, who were not well enough to leave for the off-world colonies are left behind. There is no fresh food, and inhabitants survive on Wallace's genetically modified food products sold from vending machines at street markets.