Chicken Polyclonal Calnexin Primary Antibody for ICC, IF - ABIN361839
(10 Publications):
Galvin, Krishna, Ponchel, Frohlich, Cummings, Carlson, Wands, Isselbacher, Pillai, Ozturk: The major histocompatibility complex class I antigen-binding protein p88 is the product of the calnexin gene. in Proceedings of the National Academy of Sciences of the United States of America 1992
(PubMed)

Calnexin, an abundant ~90 kDa integral protein of the endoplasmic reticulum, is also referred to as IP90, p88 and p90 (1). It consists of a large 50 kDa N-terminal calcium-binding luminal domain, a single transmembrane helix and a short acidic cytoplasmic tail (2, 3). Unlike its ER counterparts which have a KDEL sequence on their C-terminus to ensure ER retention (4), calnexin has positively charged cytosolic residues that do the same thing (3). Most ER proteins act as molecular chaperones and participate in the proper folding of polypeptides and their assembly into multi-subunit proteins. Calnexin together with calreticulin, plays a key role in glycoprotein folding and its control within the ER, by interacting with folding intermediates via their mono-glycosylated glycans (5, 6). Calnexin has also been shown to associate with the major histocompatibility complex class I heavy chains, partial complexes of the T cell receptor and B cell membrane immunoglobulin (7).Cellular Localization: Endoplasmic Reticulum | Endoplasmic Reticulum Membrane | Melanosome

Galvin, Krishna, Ponchel, Frohlich, Cummings, Carlson, Wands, Isselbacher, Pillai, Ozturk: "The major histocompatibility complex class I antigen-binding protein p88 is the product of the calnexin gene." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 89, Issue 18, pp. 8452-6, 1992