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In all these instances we also noticed that the snoRNA precursor (only seen in double ctk1D/rrp6D mutants when its conversion to the experienced variety is significantly less efficient) migrates anomalously, with lengthier varieties that extend in some instances for numerous hundred bases. These

Intrathymic bone marrow injection was performed as formerly explained [23]. Bone marrow cells (26106) in ten mL RPMI were injected into every thymic lobe of anesthetized mice using a one mL syringe with an attached 28G needle mounted on a Stepper (Tridak). Ten times later, chimerism of bone marro