Wergeland, Anita(Doctoral thesis, The University of Bergen, 2013-10-18)

Chemotherapy has a long history in cancer treatment, and the anthracycline used in
Paper I and II are among the most effective anti-cancer drugs developed.
Unfortunately, the use of anthracyclines is dose-restricted due ...

Human mesenchymal stem cells are primary multipotent cells capable of differentiating into several cell types including adipocytes when cultured under defined in vitro conditions. In the present study we investigated ...

Autoimmune Addison's Disease (AAD) is an endocrine and immunological disease of uncertain pathogenesis resulting from the immune system's destruction of the hormone producing cells of the adrenal cortex. The underlying ...

Duplication of chromosomal arm 20q occurs in prostate, cervical, colon, gastric, bladder, melanoma, pancreas and breast
cancer, suggesting that 20q amplification may play a causal role in tumorigenesis. According to an ...

Two novel cyclic lipopeptides, anabaenolysin A and anabaenolysin B, were isolated from two benthic cyanobacterial strains of the genus Anabaena. This novel class of cyanobacterial lipopeptides has a general structure of a ...

The immediate early gene Arc is emerging as a
versatile, Wnely tuned system capable of coupling changes
in neuronal activity patterns to synaptic plasticity, thereby
optimizing information storage in the nervous ...

Synaptic plasticity is the ability of neuronal
synapses to change in strength over time, and is
considered to be a foundation for learning and
memory. Long-term potentiation (LTP) is a widely
studied form of synaptic ...

Radiologists and medical practitioners are working daily with images from integrated Positron Emission Tomography/ Computed Tomography (PET/CT) scanners in order to detect potentially lethal diseases. It is thus very ...

Parkinson disease (PD) is a common
neurodegenerative movement disorder that increases
in prevalence with age. It is characterized
clinically by resting tremor, rigidity,
bradykinesia, and failing balance, and is due ...

Attention-deficit/hyperactivity disorder (ADHD) is currently a prevalent diagnosis in
child psychiatry, typically affecting 2-5 % of school-aged children world-wide. The
recent and increasing awareness that ADHD may ...

Background: The Attention Network Test (ANT) generates measures of different aspects of attention/executive
function. In the present study we investigated whether adults with ADHD performed different from controls ...

Autoimmune Addison's Disease (AAD) is a classical organ-specific autoimmune disease
(AID) that is characterized by autoreactivity towards the adrenal cortex, leading to
insufficient production of steroid hormones and ...

Mitochondrial morphology and function are coupled in healthy cells, during pathological conditions and (adaptation to) endogenous and exogenous stress. In this sense mitochondrial shape can range from small globular ...

Anti-angiogenic therapy in glioblastoma (GBM) has unfortunately not led to the anticipated improvement in patient prognosis. We here describe how human GBM adapts to bevacizumab treatment at the metabolic level. By performing ...

Omer, Abedelfattah Atif Taher(Master thesis, The University of Bergen, 2014-01-18)

Collagen 1 and fibronectin are extracellular matrix proteins that contribute in cell activity and
involve in regulating dental pulp stem cells. The purpose of this in vitro study was to investigate
the effect of collagen ...

The last century has seen an incredible leap in human medicine, which has led to an increased life expectancy spanning over all age groups. Despite this development of modern medicine some patient groups do not have any ...