A combined method consisting of extraamniotic infusion of normal saline with prostaglandin F2 alpha was used in 20 patients for termination of midtrimester missed abortion. All 20 patients aborted within 12 h. The mean infusion abortion interval was 7.34 h. Side effects were observed only in 5 patients (25%), a low percentage when compared with other prostaglandin methods. The possibility of adjusting or stopping the infusion permitted the rapid control of side effects and the intensity of uterine contractions. According to the results obtained in this series, the proposed method seems to be more suitable than other procedures reported for termination of midtrimester missed abortion.