Synergistic Toxicity

What most people fail to understand is when chemicals enter the body, they don’t remain isolated. You may get chemicals entering the body from different sources at different times, but as they work their way around the body and when some combine with other chemicals they result in devastating effects, as the experiments results below indicate. What kind of impact can this have on a newborn child?

Quotes“And combination of substances in toxicology can be greater than the sum of its parts. “With lead and mercury, for instance, a toxicity rating of 1 for each mercury and lead equals not 2, but 60 when combined.”—Hal Huggins

We now know that aluminum causes significant abnormalities in neurotubules, microscopic tubes in neurons essential to their function, and these abnormal neurotubules are strongly associated with Alzheimer’s disease. Aluminum enters the brain by a number of mechanisms, for example by attaching to glutamate and fluoride. With the widespread use of the excitotoxin glutamate as a food additive and fluoride being added to drinking water supplies, aluminum absorption is common. In addition, injected aluminum can complex with fluoride within the body to produce a compound, fluoroaluminum, that has a number of harmful effects, including brain injury. There is some evidence that fluoride can trigger microglial activation and excitotoxicity, which in combination is particularly injurious to the brain. (Blaylock, RL. Fluoride 2004:37(4);301 -314.) Vaccine Safety Manual by Neil Z. Miller. (Preface)

“One publication showed that combining mercury and lead both at LD1 levels caused the killing rate to go to 100% or to an LD100 level (12). An LD1 level is where, due to the low concentrations, the mercury or the lead alone was not very toxic alone (i.e., killed less than 1% of rats exposed when metal were used alone). The 100% killing, when addition of 1% plus 1% we would expect 2%, represents synergistic toxicity. Therefore, mixing to non-lethal levels of mercury plus lead gave an extremely toxic mixture! What this proves is that one cannot define a “safe level of mercury” unless you absolutely know what others toxicants the individual is being exposed to. The combined toxicity of various materials, such as mercury, Thimerosal, lead, aluminum, formaldehyde, etc., is unknown. The effects various combinations of these toxicants would have is also not defined except that we know they would be much worse than any one of the toxicants alone. So how could the ADA take any exception, based on intellectual considerations, to my contention that combinations of Thimerosal and mercury could exacerbate the neurological conditions identified with autism and AD? Autism and AD have clinical and biological markers that correspond to those observed in patients with toxic mercury exposure. Why would the ADA take this position? I personally feel like I have been in a ten-year argument with the town drunk on this issue. Facts don’t count and data is only valid if it meets the pro-amalgam agenda……The synergistic effects of mercury with many of the toxicants commonly found in our environment make the danger unpredictable and possibly quite severe, especially any mixture containing elemental mercury, organic mercury and other heavy metal toxicants such as aluminum.”–Boyd Haley http://www.whale.to/m/haley.html

• Aluminum, copper, lead , mercury, and cadmium can be found in mussels at levels that, individually, are considered below the threshold of toxic harm. But these metals act synergistically with low concentrations of the mussel’s own okadaic acid to kill cells.

• PBDEs, PCBs, and methylmercury are each synergistically toxic with the others. Very low exposures combine to induce greater than expected harm.

• In general, metals have synergistic toxicity — and organic metals have synergistic toxicity with organic compounds. Research indicates that low PCB exposure while in the womb, in combination with low exposure to methylmercury and lead, results in cognitive impairment.

• Exposure to a combination of 1 PCB, 2 dioxins, and 3 pesticides means a person is 38x more likely to develop type-II diabetes than someone exposed to just 1 of the chemicals.

• Lupus clusters — the localized outbreaks of lupus at rates much higher than in the general population — are associated with sites generating multiple chemical exposure. In this example the rate of lupus was 30x to 99x higher for people living in a 6-block area built atop a retired oil field waste pit. Key contaminants were determined to be mercury, pristane, and phytane.

• Tungsten and cobalt together can be carcinogenic and together have been found to rapidly accelerate the growth of human leukemia cells.

• Titanium dioxide nanoparticles are being used in an expanding range of products. These nanoparticles have ben observed to greatly enhance the accumulation of cadmium in fish.

• Melamine and cyanuric acid are both considered non-toxic at low doses. But if those low doses combine in the kidneys, a fatal amount of crystals can form. Melamine and cyanuric acid were added to wheat gluten used as an ingredient in animal chows that caused the death of hundreds of pets in early 2007. Similar meals have been fed to farmed chickens, pigs, and fish. In September 2008 melamine was identified in at least 22 brands of Asian baby formula after an unusually high incidence of kidney stones were reported in infants, including several deaths. In November 2008 melamine and/or cyanuric acid were identified in several major brands of U.S. baby formula (Abbot Labs = Similac, Mead Johnson = Enfamil, Nestle = Good Start). Initially the FDA stated that any amount of exposure to melamine is unsafe for infants, but later asserted that 1 ppm melamine or 1 ppm cyanuric acid is safe as long as both chemicals are not present at the same time. Whether these levels are truly safe enough for infants remains unknown.

• Rats who drank milk retained 2x more mercury in their bodies than rats who didn’t.

• The dust shed by automotive tires contains a mixture of chemicals. These chemicals act in synergy with each other.

• Microscopic particles in diesel exhaust combine with lipids in cholesterol to activate genes that trigger inflammation of blood vessels, in turn leading to atherosclerosis, heart attacks and strokes.

• Gardasil recipients who reported an adverse reaction to the Vaccine Adverse Events Reporting System (VAERS) were 3.3x more likely to report a neuromuscular and coordination problem if they were injected with Menactra at the same time.

Slide 25 from this presentation by Dr. Boyd Haley illustrates the synergistic toxicity of three ingredients commonly found in vaccines — thimerosal, aluminum hydroxide (AlOH3), and neomycin.

• By themselves, neomycin and AlOH3 are less cytotoxic than thimerosal.

• 24 hours after a 50nM (50 ppb) exposure to thimerosal, less than 40% of cells survived.

• 12 hours after a combination of thimerosal and neomycin, roughly the same number of cells died.

• 6 hours after combining thimerosal, neomycin, and aluminum hydroxide, the same number of cells died — and by 24 hours all cells were dead.

• Adding testosterone to the other three made the toxic effect total and immediate — all cells were dead within 3 hours.