Researchers found treatment of MLL-fusion leukemia cells with the BET bromodomain inhibitor I-BET151 resulted in selective growth inhibition, whereas treatment of leukemia cells harboring a different oncogenic driver did not result in selective growth inhibition. [Elife]
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Linc00152 was up-regulated in glioma tissues as well as in glioma stem cells (GSCs). Knockdown of linc00152 inhibited cell proliferation, migration and invasion, while promoted GSC apoptosis. [Mol Cancer]
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A naturally occurring compound phenethyl isothiocyanate (PEITC) has been shown to have promising anticancer activity by modulating intracellular ROS. Authors report a novel synthetic analog of PEITC with superior in vitro and in vivo antitumor effects. [Cell Death Dis]
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The authors investigated the glioblastoma (GBM) ability to interconvert between stem and non-stem states through the evaluation of the expression of specific stem cell markers as well as cell communication proteins. [Transl Oncol]
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High levels of mitochondrial fission activity are associated with high proliferation and invasiveness in some cancer cells and with self-renewal and resistance to differentiation in some stem cells. These observations reveal new ways in which mitochondria regulate cell physiology, through their effects on metabolism and cell signaling. [Cell Metab]
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Therapies targeted at CSCs, such as those employing metformin and salinomycin seem promising. Anti-angiogenic therapy with bevacizumab was found to be effective in all phases of ovarian cancer treatment. [Eur J Med Chem]
Abstract

An understanding of the underlying pathogenesis of squamous cell carcinoma (SCC), with the identification of its cell of origin, is critical for developing targeted strategies for effective SCC treatment. [Int J Mol Sci]
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Boston Biomedical intends to work with study investigators to complete a full evaluation of the BRIGHTER Trial results. Final data and analyses will be provided to regulatory authorities and will be presented and published for the oncology community. [Boston Biomedical, Inc.]
Press Release

The Court of Justice of the European Union in Luxembourg handed down a judgment in a compensation case involving a French man who claimed that a vaccination for hepatitis B caused his multiple sclerosis. The ruling specifies what type of evidence is allowed in EU member states in such cases, but it prompted a flurry of negative press coverage. [Nature News]
Editorial

The Russian government has taken further steps to tighten its grip on the Russian Academy of Sciences (RAS) in Moscow. The State Duma—one of the two chambers of the Russian parliament—passed the first draft of a new law that would give president Vladimir Putin the final say in the elections for RAS’s presidency. [ScienceInsider]
Editorial

The US Supreme Court has reinstated a limited version of President Donald Trump’s temporary order banning travellers from six Muslim-majority countries from entering the United States. The court will hear a legal challenge to the ban in October. The court’s decision casts doubt on the fate of students and scientists from these countries who hope to study or work in the United States. [Nature News]
Editorial