Effects of the histaminergic system on the morphine-induced conditioned place preference in mice

@article{Suzuki1995EffectsOT,
title={Effects of the histaminergic system on the morphine-induced conditioned place preference in mice},
author={Tsutomu Suzuki and Kazuaki Takamori and Miwa Misawa and Kenji Onodera},
journal={Brain Research},
year={1995},
volume={675},
pages={195-202}
}

The effects of an H2 receptor antagonist, a histidine decarboxylase inhibitor and a histamine precursor on the morphine-induced place preference in mice were examined. Morphine (1-7 mg/kg) produced a place preference in a dose-dependent manner. This morphine-induced place preference was significantly antagonized by the dopamine (DA) D1 receptor antagonist SCH 23390. The histamine precursor, L-histidine, attenuated the morphine (7 mg/kg)-induced place preference. On the other hand, the histidine… CONTINUE READING