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Lisa arrived in April 2016, when her abductor Margaret Smith was being attacked by Simone. Lisa asked what was happening, Margaret cowered, saying that she shouldn't be there. Simone and Louis were thrilled to have them back, but Lisa made it clear she didn't want to be with them. Margaret was arrested, and Zack Loveday and Sonia Albright convinced Lisa to stay.

Mac and Lisa begin a full-blown affair behind Nathan and Marnie's backs, with them arranging to go away on luxury weekend breaks together. Nathan, meanwhile, comforts Cleo after Celine goes missing, unaware that she has actually been murdered by Cameron Campbell (Cameron Moore). While on a romantic getaway, Mac accidentally runs Cameron over, with Lisa attempting to help him. Mac orders Lisa to leave him, and the pair drive off. Cameron remembers Lisa trying to help him, and begins blackmailing the pair from prison. However, this soon stops, but Marnie and Nathan find blood on Mac's van, with Marnie taking the vehicle to be scrapped to save Mac. Nathan, however, finds one of Lisa's bras in the back, and confronts him about cheating on Marnie, unaware that the bra is Lisa's. On the day of Celine's funeral, Cleo finally decides to tell Nathan how she really feels, however Nathan has just gotten engaged to Lisa. At the engagement party, Mac and Lisa begin to have sex, but Nathan walks in on them. As Mac attempts to explain, Nathan stumbles backwards and falls out of the window, with Cleo watching in horror. As Cleo, Mac, Marnie, Lisa, Ellie, Alfie and Freddie Roscoe (Charlie Clapham) rush to help, Nathan manages to utter the word "dad" before dying from his injuries in Marnie's arms.