Footnotes

↵1 This study was supported in part by National Institutes of Health Grants GM43776 and GM47502. Portions were presented in part at the 1994 and 1997 annual meetings of the American Society of Anesthesiologists [Krejcie TC, Henthorn TK, Gentry WB, Shanks CA, Enders C, Van Drie J and Avram MJ (1994) The effect of altered blood volume on intravascular mixing. Anesthesiology81:A410; and Krejcie TC, Henthorn TK, Niemann CU, Klein C, Shanks CA and Avram MJ (1997) The effect of blood volume on drug disposition from the moment of injection. Anesthesiology87:A351].