Guests on the show this season include Los Angeles Dodgers outfielder Andre Ethier, as well as Disney Channel star Karan Brar (Jessie). Also, Lab Rats star Hal Sparks makes his directorial debut with an episode.

Season 3 of Lab Rats follows the Davenport family in damage control, after their secret is revealed. They also must recover from an attack by a nemesis, leaving their empire in ruins. Lab Rats comes from executive producers Chris Peterson and Bryan Moore (That '70s Show) and Hayes Jackson (According to Jim).