Constrictive Bronchiolitis

Common Name(s)

Constrictive Bronchiolitis

Constrictive bronchiolitis, also known as bronchiolitis obliterans, is a respiratory illness that affects the smallest air passages in the lungs, known as the bronchioles. Bronchioles normally control airflow in the lungs. Individuals with constrictive bronchiolitis have bronchioles that are compressed and narrowed by fibrosis (scar tissue) and/or inflammation (swelling). Symptoms may include shortness of breath, dry cough, or wheezing. Diagnositic testing may include a chest xray, chest cat scan (CT) and pulmonary function testing (measures the airflow in your lungs). Early inspiratory crackles may also be heard by your physician while listening to your lungs. Constrictive bronchiolitis may occur after a lung transplantation or a respiratory infection or due to exposure to certain toxic (poisonous) fumes or taking certain medications. Some connective tissue disorders also involve constrictive bronchiolitis. If the condition is due to inflammation, steriod treatments may be successful. If the condition is due to scarring, the damage is irreversible although steroid treatments may help manage the symptoms. The development of antifibrotic medications is rapidly progressing with advances in medical research. Talk with your doctor about treatment and management options if you or a family member has been diagnosed with constrictive bronchiolitis.

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Advocacy and Support Organizations

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Finding the right clinical trial for Constrictive Bronchiolitis can be challenging. However, with TrialsFinder (which uses the Reg4ALL database and privacy controls by Private Access), you can permit researchers to let you know opportunities to consider - all without revealing your identity.

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Constrictive Bronchiolitis" returned 7 free, full-text research articles on human participants.
First 3 results:

In this descriptive case series, 80 soldiers from Fort Campbell, Kentucky, with inhalational exposures during service in Iraq and Afghanistan were evaluated for dyspnea on exertion that prevented them from meeting the U.S. Army's standards for physical fitness.

Constrictive bronchiolitis obliterans is a fibrotic disease of small airways characterized by progressive obliteration of the airway lumen, with resulting obstructive pulmonary physiology. While previous work has demonstrated the collagenous nature of the constrictive fibrotic lesions, ...

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Constrictive Bronchiolitis" returned 2 free, full-text review articles on human participants.
First 3 results:

New literature from 2009 to 2012 regarding occupational constrictive bronchiolitis challenges textbook descriptions of this disease, formerly thought to be limited to fixed airflow limitation arising in the wake of accidental overexposure to noxious chemicals. Indolent evolution of ...

Oxidants such as superoxide anion, hydrogen peroxide, and myeloperoxidase from activated inflammatory cells in the lower respiratory tract contribute to inflammation and injury. Etiologic agents include inorganic particulates such as asbestos, silica, or coal mine dust or mixtures ...

According to ClinicalTrials.gov there are currently 0 additional "open" studies for "Constrictive Bronchiolitis" (open studies are recruiting volunteers) and 3 "Constrictive Bronchiolitis" studies with "all" status. Visit ClinicalTrials.gov now to view them. Or alternatively, consider TrialsFinder for assistance:

Relief is when you and the right researcher find each other
Finding the right clinical trial for Constrictive Bronchiolitis can be challenging. However, with TrialsFinder (which uses the Reg4ALL database and privacy controls by Private Access), you can permit researchers to let you know opportunities to consider - all without revealing your identity.