Four-time Emmy winner Parsons, who played the cranky, finicky genius for 12 seasons on hit CBS comedy “The Big Bang Theory,” takes on an entirely different character – physically, psychologically and morally – in Netflix’s “Hollywood” (now streaming), his first major role since “Big Bang” ended last May. For Parsons’ jaw-dropping introductory scene as sleazy talent agent Henry Willson, an act of brutal psychological and physical aggression, naïve Sheldon might want to avert his eyes.

The seven-episode limited series from producers Ryan Murphy, Ian Brennan and Janet Mock embraces the elegance and mystery of the film industry’s post-World War II golden era while imagining an alternate ending in which women, people of color, the LGBTQ+ community and others who had been marginalized get the leading roles, literally and figuratively, that many are still being denied.

Parsons, 47, whose character is the real-life rep of Hudson, likes the “bittersweet” imagining of what Hollywood might be like if the events portrayed in “Hollywood” had occurred nearly 80 years ago.

“As somebody who’s part of the business now, it’s very evident how eager and desirous most of Hollywood, in my opinion, is to tell stories that haven’t been told from people that we haven’t seen yet,” says Parsons, whose career happily didn’t suffer when he came out as gay during the “Big Bang” run. “Once you watch some of these brave choices being made in the ’40s, the mind reels in that fantasy of what life would look like now had this happened then. It’s a real call to not feel overly satisfied about where we are now.”

Parsons took on the creepy, corrupt Willson at the behest of Murphy, after they worked together on HBO’s 2014 adaptation of “The Normal Heart” and Netflix’s remake of “The Boys in the Band,” due later this year.

He didn’t knowmuch about Willson, who created his “own little (talent) factory, pumping out those milk-fed all American hunks with quick names like Rock, Guy and Tab,” Parsons says.

“Hollywood” also portrays a seamier side of Willson, as the agent employs blackmail and mob connections to get his way and demands sexual favors from handsome young actors.

“He was such a complicated, colorful, outlandish character, and despicable in many ways, that he’s the kind of person that it would be easy to lump into a category” as a black-and-white villain, Parsons says. “I knew I was going to have to do my best to make him sound believable and find legitimate (or) empathetic reasons he might do the things he does.”

That included the kind of sexual harassment that has cost several contemporary Hollywood power players their jobs with the rise of the #MeToo movement. In “Hollywood” and in the real industry at that time, casting-couch behavior was rampant, although Willson likely was judged more harshly because he was gay, Parsons says.

Murphy thought Willson was just the role to set Parsons on a dramatically different path after “Big Bang.”

“I call this Jim’s Mary Tyler Moore moment. Jim is a brilliant actor and I think so many people just think of him as Sheldon. Mary Tyler Moore, when she finished her sitcom, went and did ‘Ordinary People,’ America’s sweetheart suddenly becoming America’s villain,” Murphy says. “I just thought Jim would kill this part. He got to wear false teeth and a bald spot and he got to be (a character) he’s never done. I think it was very liberating for him.”

Jim Parsons, left, and Mayim Bialik, seen here as Sheldon Cooper and Amy Farrah Fowler in ‘The Big Bang Theory,’ are producing ‘Call Me Kat,’ a Fox comedy that will feature Bialik in the lead role.(Photo: Michael Yarish/WARNER BROS.)

Parsons agrees. “I can only describe it as being a kid in the candy store as an actor. It offered me the opportunity to see how hungry I was to play something different.”

He doesn’t miss making “Big Bang,” but a year after taping the finale and amid a coronavirus quarantine, “it has made me realize the hollow part of not seeing so many people for so long,” he says. “You take it for granted when you’re with them most days for nine months a year for 12 years, and then they’re suddenly just not part of your orbit anymore. I think of that now, because I have a lot of time to think about it.”

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