Viral insertion. DCIS is the earliest phase of transformation to malignancy developing in the ductal system before invasion into parenchyma has occurred. It is defined on mammo by clustered microcalcification. In general the long terminal repeat of the MMTV viral genome enters the ductal cell to initiate transformation. with time the cells become aggressive and invade basement membrane helped by the EBVvirus.

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Related Questions

Genetic mutations. This is mostly a random event. There's a natural instability in the human genome even if you are never exposed to anything that's obviously a mutagen. The other factors that place you at risk for breast cancer (nulliparity, brca1 / brca2 mutations, etc.) are risk factors here, but no woman (and actually no man either) is immune.
Read more...

"in place" Ductal carcinoma in situ (DCIS) of the breast is a breast cancer which has started in the ducts of milk glands (as most breast cancers do) but not yet invaded beyond that into the fat of the breast. Untreated, it has a high likelihood of becoming invasive breast cancer, a potentially fatal disease. Treated DCIS has a high cure rate. Some with DCIS benefit from taking med to prevent 2nd cancer.
Read more...

Surgery. The extent of the disease, that is how big it looks, on the mammogram or MRI will be a big factor in discussion with your surgeon about how best to treat this tumor. If small, then many women prefer lumpectomy (removal of the dcis and a clean margin of breast tissue) and radiation. If the area is large, then mastectomy with or without reconstruction is usually preferred.
Read more...

INVASIVE or DCIS? These terms are incongruous: dcis is, by definition, breast cancer that has not "broken out" of the ducts and entered the adjacent supportive tissue of the breast; invasive, or infiltrating ductal cancer, by definition, has. The treatment of these 2 diseases is quite different since there is a risk of systemic disease with the latter. Please clarify, thanks.
Read more...

No good answer here! Invasive ductal carcinoma, and ductal carcinoma in situ are not the same thing. They are often treated in similar fashion, with surgery and radiation. But without a clear understanding of what you are describing there is unfortunately no good answer here.
Read more...

Invasive or in situ? One needs to differentiate between invasive and in situ cancer. The local therapy options are generally the same (breast conservation versus mastectomy). Invasive cancer however requires additional attention focused on systemic issues. In situ disease by definition has not yet developed the potential to spread/metastasize.
Read more...

Excellent. The prognosis for people with dcis is excellent, with cure rates approaching 100%. Treatment varies by the type and extent of dcis: sometimes a lumpectomy alone is sufficient, often supplemented by radiation therapy. Occasionally, it may be best to have a mastectomy if the dcis is present throughout the breast. After treatment, tamoxifen is offered to prevent a second cancer from developing.
Read more...

Excellent Prognosis. Dcis is usually treated with a combination of surgery followed by radiation therapy. The local control rates approach 100% this way. Cosmetic outcome is usually good to excellent and treatment itself is generally well tolerated.
Read more...

DCIS. We dont consider dcis as an invasive breast cancer- rather we consider this as a precancer condition./ a non-invasive breast cancer- localized only on the duct or stage t0. You are right -there are a lot of factors that perhaps can contribute to development of cancer- like lifestyle/habits ( smoking/alcohol, lack of exercise) , nutrition/diet ( certain food/amino acids that is carcinogenic) etc.
Read more...

YES. Ductal carcinoma in situ means that the cancer is there in the duct but it has not invaded into the surrounding tissues of the breast. This means it was found early. Can living a healthy lifestyle help? Yes it can but it cannot fix it. Get this removed before it becomes a more progressive invasive cancer.
Read more...

Yes and No. Ductal carcinoma in situ is basically a cancer which has not yet become invasive. The only way to treat this is to get rid of it before it turns into an invasive cancer. Because it is detected early, surgery provides a high rate of cure.
Read more...

Precancerous. Carcinoma in-situ is just one step short of cancer. There is no scientific evidence for or against life style changes altering the course of in-situ lesions. You may engage in life style changes that promote a healthy life style but should not omit conventional treatment. Steve jobs low grade cancer became fatal while he tried to treat it by alternative methods. See your doctor.
Read more...

Another point. In addition to all of the other answers, there are some new ideas about this problem. The danger with this disease is that you are more likely to get invasive cancers. There is a recently developed test that can give a much better idea of who will get invasive cancer, and who benefits from radiation.
Read more...

cancer and clot. Multifocal means mutiple seperate sites of cancer cells in the ducts or tubes of the breast. In situ means the cancer has not spread outside the ducts, into the surrounding breast tissue. In this instance the problem is in the left breast.
Subdural hematoma is a blood clot between the brain surface and the membrane (called dura) covering the brain. In this instance the clot is the right side.
Read more...

Depends tumor size. If tumor small and was non palpable but only defined on mammogram, if lesion with intraductal components smaller than 1 cm, and sentinel node bx neg. I would wait to hear about margins. Margins that are adequate about 1cm around lesion suggests lesion in high 90% cure without RT. If larger lesion then possibly RT and tamoxifen.
Read more...

Related Questions

Genetic mutations. This is mostly a random event. There's a natural instability in the human genome even if you are never exposed to anything that's obviously a mutagen. The other factors that place you at risk for breast cancer (nulliparity, brca1 / brca2 mutations, etc.) are risk factors here, but no woman (and actually no man either) is immune.
Read more...

"in place" Ductal carcinoma in situ (DCIS) of the breast is a breast cancer which has started in the ducts of milk glands (as most breast cancers do) but not yet invaded beyond that into the fat of the breast. Untreated, it has a high likelihood of becoming invasive breast cancer, a potentially fatal disease. Treated DCIS has a high cure rate. Some with DCIS benefit from taking med to prevent 2nd cancer.
Read more...

Surgery. The extent of the disease, that is how big it looks, on the mammogram or MRI will be a big factor in discussion with your surgeon about how best to treat this tumor. If small, then many women prefer lumpectomy (removal of the dcis and a clean margin of breast tissue) and radiation. If the area is large, then mastectomy with or without reconstruction is usually preferred.
Read more...

INVASIVE or DCIS? These terms are incongruous: dcis is, by definition, breast cancer that has not "broken out" of the ducts and entered the adjacent supportive tissue of the breast; invasive, or infiltrating ductal cancer, by definition, has. The treatment of these 2 diseases is quite different since there is a risk of systemic disease with the latter. Please clarify, thanks.
Read more...

No good answer here! Invasive ductal carcinoma, and ductal carcinoma in situ are not the same thing. They are often treated in similar fashion, with surgery and radiation. But without a clear understanding of what you are describing there is unfortunately no good answer here.
Read more...

Invasive or in situ? One needs to differentiate between invasive and in situ cancer. The local therapy options are generally the same (breast conservation versus mastectomy). Invasive cancer however requires additional attention focused on systemic issues. In situ disease by definition has not yet developed the potential to spread/metastasize.
Read more...

Excellent. The prognosis for people with dcis is excellent, with cure rates approaching 100%. Treatment varies by the type and extent of dcis: sometimes a lumpectomy alone is sufficient, often supplemented by radiation therapy. Occasionally, it may be best to have a mastectomy if the dcis is present throughout the breast. After treatment, tamoxifen is offered to prevent a second cancer from developing.
Read more...

Excellent Prognosis. Dcis is usually treated with a combination of surgery followed by radiation therapy. The local control rates approach 100% this way. Cosmetic outcome is usually good to excellent and treatment itself is generally well tolerated.
Read more...

DCIS. We dont consider dcis as an invasive breast cancer- rather we consider this as a precancer condition./ a non-invasive breast cancer- localized only on the duct or stage t0. You are right -there are a lot of factors that perhaps can contribute to development of cancer- like lifestyle/habits ( smoking/alcohol, lack of exercise) , nutrition/diet ( certain food/amino acids that is carcinogenic) etc.
Read more...

YES. Ductal carcinoma in situ means that the cancer is there in the duct but it has not invaded into the surrounding tissues of the breast. This means it was found early. Can living a healthy lifestyle help? Yes it can but it cannot fix it. Get this removed before it becomes a more progressive invasive cancer.
Read more...

Yes and No. Ductal carcinoma in situ is basically a cancer which has not yet become invasive. The only way to treat this is to get rid of it before it turns into an invasive cancer. Because it is detected early, surgery provides a high rate of cure.
Read more...

Precancerous. Carcinoma in-situ is just one step short of cancer. There is no scientific evidence for or against life style changes altering the course of in-situ lesions. You may engage in life style changes that promote a healthy life style but should not omit conventional treatment. Steve jobs low grade cancer became fatal while he tried to treat it by alternative methods. See your doctor.
Read more...

Another point. In addition to all of the other answers, there are some new ideas about this problem. The danger with this disease is that you are more likely to get invasive cancers. There is a recently developed test that can give a much better idea of who will get invasive cancer, and who benefits from radiation.
Read more...

cancer and clot. Multifocal means mutiple seperate sites of cancer cells in the ducts or tubes of the breast. In situ means the cancer has not spread outside the ducts, into the surrounding breast tissue. In this instance the problem is in the left breast.
Subdural hematoma is a blood clot between the brain surface and the membrane (called dura) covering the brain. In this instance the clot is the right side.
Read more...

Depends tumor size. If tumor small and was non palpable but only defined on mammogram, if lesion with intraductal components smaller than 1 cm, and sentinel node bx neg. I would wait to hear about margins. Margins that are adequate about 1cm around lesion suggests lesion in high 90% cure without RT. If larger lesion then possibly RT and tamoxifen.
Read more...