A 73-year-old female Singaporean was seen in this clinic in September 2010 because of numerous vesicles base distributed mainly on arms and both lower limbs (Fig.1-A), the skin on her both ankle and dorsum of feet is dry, red, scaling, and thickened.

A 12-year-old girl began to suffer from psoriasis vulgaris (guttate type) in February of 2005. She presented at Tang Jinghua Clinic on 9th March, 2005. The discrete, erythematous scaling, small papules and plaques were distributed mainly on the trunk (Fig.1-A). Patient blood pressure, pulse and temperature were all normal, she had no backache, no history of any drug used, and no history of syphilis.

A 58-year-old female Singaporean had been well until a year earlier when she developed a scaly red rash over her knees and shins, and then with an identical distribution on both arms. She was clinically diagnosed with plaque psoriasis at the National Skin Centre.

A 21-year-old boy presented in March 2009 at our clinic with symptoms and signs of crusting erythema plaques all over his face and body (Fig.1-A). He had suffered from eczema since he was 10 months old, when he developed a scaly red rash over his cheeks and over his knees and elbows. His elder brother and father suffer from hay fever. In the past 20 years, he had been treated with antihistamines, antibiotics and topical corticosteroids alternatively and concurrently, during which time no improvement occurred: new eczematous lesions continued to develop and spread on his trunk, hands, feet and face.

A 13-year-old girl had suffered from eczema since she was 5 years old, when she developed a scaly red rash over her knees and elbows (Fig.1-A, Fig.2-A). Her father had atopic dermatitis, and the family lived in a southern city in China before they immigrated to Singapore. There were no pets, and her parents did not smoke.

A 44-year-old male presented with large confluent reddish plaques on the legs (Fig.1-A). He had been diagnosed with psoriasis 8 years earlier. On examination, well-demarcated erythematous plaques arising on the lower legs (Fig.1-A) could be seen. No hair loss and no diarrheal, with no other diseases reported by the patient. Laboratory serum investigation revealed no abnormal findings, temperature was 37.1°C. The patient reported no oral medication use during the past 8 years, but was unable to recall the names and types of creams applied previously.

A 34-year-od woman presented with reddish papules covered by silvery-white scales, on her right areola and breast area of a 1-year duration. She had undergone ultrasound mammary scanning one month earlier, no abnormality had been noted. She was married 4 years and reported no itch and no rashes in the groin, perineum and axilla area; no discharge from the nipple during the onset period.

A 13-year-old girl was seen in the clinical centre because of reddish plaques with loosely adherent silvery-white lamellar scales on her two legs (Fig.1-A). The patient had been well until approximately 6 years earlier, when she fell down and injured her knees, a sharply marginated erythematous papule with a silvery-white scale developed on her knees, the scales are lamellar, loose and easily removed by scratching. During the next 5 years, the patients applied various creams and ointments, the lesion subsided then later on flared up and spread when the topical cream discontinued. Patient has no familial history of skin diseases.

A 43-year-old man was seen in the clinical centre because of silvery scales covering his entire scalp, and scattered salmon-pink papules on the face and forehead. The patient had been well until approximately 1.5 years earlier, when silvery scales developed, first on his scalp, and then gradually covering his entire scalp.