Browse our anti-ATF6 (ATF6) Antibodies

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anti-Activating Transcription Factor 6 Antibodies (ATF6)

On www.antibodies-online.com are 184 Activating Transcription Factor 6 (ATF6) Antibodies from 29 different suppliers available. Additionally we are shipping ATF6 Kits (31) and ATF6 Proteins (12) and many more products for this protein. A total of 239 ATF6 products are currently listed.

The expression of ASNS (show ASNS Antibodies) was significantly elevated when ATF6 was over expressed. The expressions of these 2 genes were both decreased in hepatocellular carcinoma (HCC (show FAM126A Antibodies))patients, and it was more significantly with ASNS (show ASNS Antibodies). The mRNA levels of ASNS (show ASNS Antibodies) and ATF6 were positively correlated with each other. rs34050735 was associated with HCC (show FAM126A Antibodies) in the case-control study and also an independent predictor of overall survival of HCC (show FAM126A Antibodies) patients.

This review shown that the achromatopsia arising from genetic mutations in Activating Transcription Factor 6 (ATF6).

In summary, our study revealed a negative regulation of the UPR transducer ATF6 through post-translational SUMOylation. The information from this study will not only increase our understanding of the fine-tuning regulation of the UPR signaling but will also be informative to the modulation of the UPR for therapeutic benefits.

we show that overexpression of the dominant-negative form of ATF6 (dnATF6) increases susceptibility to develop hepatic steatosis in diet-induced insulin (show INS Antibodies)-resistant mice and fasted mice. Furthermore, hepatic overexpression of the active form of ATF6 promotes hepatic fatty acid oxidation and protects against hepatic steatosis in diet-induced insulin (show INS Antibodies)-resistant mice.

The present study extends our understanding and provides new insights into the physiological significance of ATF6, a key signal transducer of ER stress, in ovarian granulosa cells.

ATF6 serves as an important role between ER stress and oxidative stress, by decreasing myocardial ischemia/reperfusion damage.

ATF6alpha mRNA and protein levels were higher in the uterus near the implantation site following embryo implantation.

ATF6a favorably controls chondrogenesis and bone formation (1) by acting as a co-factor of Runx2 and enhancing Runx2-incited hypertrophic chondrocyte differentiation, and (2) by affecting IHH and PTHrP signaling.

ATF6 Antigen Profile

Antigen Summary

This gene encodes a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Although it is a transcription factor, this protein is unusual in that it is synthesized as a transmembrane protein that is embedded in the ER. It functions as an ER stress sensor/transducer, and following ER stress-induced proteolysis, it functions as a nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is present in the promoters of genes encoding ER chaperones. This protein has been identified as a survival factor for quiescent but not proliferative squamous carcinoma cells. There have been conflicting reports about the association of polymorphisms in this gene with diabetes in different populations, but another polymorphism has been associated with increased plasma cholesterol levels. This gene is also thought to be a potential therapeutic target for cystic fibrosis.