Medical Xpress news tagged with:androgen receptorshttp://medicalxpress.com/
en-usMedical Xpress internet news portal provides the latest news on science including: Physics, Nanotechnology, Life Sciences, Space Science, Earth Science, Environment, Health and Medicine.New imaging method can detect, monitor and guide treatment for, prostate cancerAn international group of researchers report success in mice of a method of using positron emission tomography (PET) scans to track, in real time, an antibody targeting a hormone receptor pathway specifically involved in prostate cancer. This androgen receptor pathway drives development and progression of the vast majority of prostate cancers. The technique shows promise, the investigators say, as a novel way to use such an antibody to detect and monitor prostate and other hormone-sensitive cancers, as well as to guide therapy in real time.http://medicalxpress.com/news/2016-11-imaging-method-treatment-prostate-cancer.html
CancerWed, 30 Nov 2016 14:00:04 ESTnews399736467Identification of gene defects helps the treatment of prostate cancerThe current method of treating prostate cancer involves identifying gene defects, which could help with the diagnosis of cancer and the development of individualised cancer treatments for patients. Professor Tapio Visakorpi at the University of Tampere is studying the molecular biology of prostate cancer, with funding by the Academy of Finland. The goal is to obtain a holistic picture of the disease's mechanisms and use those mechanisms as a basis for developing new treatments.http://medicalxpress.com/news/2016-11-identification-gene-defects-treatment-prostate.html
CancerFri, 04 Nov 2016 08:20:04 ESTnews397465774Serendipitous finding leads scientists to propose mechanism to explain benign prostatic hyperplasiaBenign prostatic hyperplasia (BPH), a non-cancerous enlargement of the prostate, affects about half the men between 51 and 60 years of age, and nine out of 10 men older than 80. How BPH happens, however, is still open for debate. In a paper published today in Molecular Cell, researchers at Baylor College of Medicine and other institutions report a new mechanism that can explain the development of BPH and suggest strategies to improve the response to androgen-targeting therapies, which are usually used to treat prostate cancer and BPH.http://medicalxpress.com/news/2016-09-serendipitous-scientists-mechanism-benign-prostatic.html
Diseases, Conditions, SyndromesThu, 01 Sep 2016 12:00:04 ESTnews391929943Compound shows promise as next-generation prostate cancer therapyIn the search for new ways to attack recurrent prostate cancer, researchers at Duke Health report that a novel compound appears to have a unique way of blocking testosterone from fueling the tumors in mice.http://medicalxpress.com/news/2016-08-compound-next-generation-prostate-cancer-therapy.html
CancerMon, 08 Aug 2016 11:00:04 ESTnews389852361A new method for prostate cancer imagingProstate cancer is one of the most common cancers in men. Tumor growth is critically regulated by the androgen receptor, and treatment strategies to lower androgens, such as testosterone, are a mainstay of clinical treatment. Over time, however, resistance frequently develops and the disease may progress to a castration-resistant form that expresses a variant of the androgen receptor, which evades blockade by drugs that dampen androgen receptor signaling. Thus, clinically there is an urgent need to identify patients expressing androgen receptor variants to determine which treatment options are likely to benefit patients.http://medicalxpress.com/news/2016-07-method-prostate-cancer-imaging.html
CancerThu, 21 Jul 2016 09:32:43 ESTnews388312351New cancer drugs could treat lethal resistant prostate cancersMen with aggressive prostate cancer that has stopped responding to conventional treatment could potentially benefit from a new class of cancer drug designed to overcome drug resistance, a new study suggests.http://medicalxpress.com/news/2016-05-cancer-drugs-lethal-resistant-prostate.html
CancerSun, 01 May 2016 13:11:58 ESTnews381327083Study explains how low testosterone raises diabetes riskDoctors have long known that men with low testosterone are at greater risk for developing type 2 diabetes. For the first time, researchers have identified how testosterone helps men regulate blood sugar by triggering key signaling mechanisms in islets, clusters of cells within the pancreas that produce insulin. The findings, co-authored by Tulane University researchers, are published in the journal Cell Metabolism.http://medicalxpress.com/news/2016-04-testosterone-diabetes.html
DiabetesThu, 28 Apr 2016 13:32:55 ESTnews381069153Novel molecular processes controlling key genes in prostate cancer uncoveredResearchers at Sweden's Karolinska Institutet and the University of Oulu in Finland have elucidated gene regulatory mechanisms that can explain how known genetic variants influence prostate cancer risk. The findings, published in the journal Nature Genetics, reveal widespread deregulation of androgen receptor function, a key player in prostate cancer.http://medicalxpress.com/news/2016-03-molecular-key-genes-prostate-cancer.html
CancerMon, 07 Mar 2016 11:00:10 ESTnews376561106Testosterone beyond sexWhen we think about sex hormones, notably estrogens and androgens, we usually associate them with sex, gender and body development. Like all hormones, they are chemical messengers, substances produced in one part of the body that go on to tell other parts what to do. However, we often have the tendency to forget the enormous impact that these steroid hormones have on brain functions. From animal studies, it has become clear that during early development, exposure of the brain to testosterone and estradiol, hormones present in both males and females, leads to irreversible changes in the nervous system (McCarthy et al., 2012). A growing and very appealing body of science suggests that sex hormones play a neuromodulatory role in cognitive brain function (Janowsky, 2006). Moreover, testosterone dysfunctions (hypogonadism, chemical castration, etc.) have shown to be associated with memory defects. However, in spite of these advances, it still remains an enigma how sex hormones affect the brain.http://medicalxpress.com/news/2016-02-testosterone-sex.html
NeuroscienceTue, 23 Feb 2016 09:09:04 ESTnews375440935Debiopharm, EORTC investigate triptorelin for treatment of salivary gland cancersDebiopharm International SA (Debiopharm), part of Debiopharm Group, a Swiss-based global biopharmaceutical company, today announced a collaboration in order to supply triptorelin pamoate 3.75 mg 1-month formulation for patients suffering from salivary gland cancer participating in a clinical study sponsored by the European Organisation for Research and Treatment of Cancer (EORTC).http://medicalxpress.com/news/2016-01-debiopharm-eortc-triptorelin-treatment-salivary.html
CancerThu, 14 Jan 2016 13:15:22 ESTnews371999716Phase 1 results point to larger trial of enzalutamide and fulvestrant in breast cancerResults of a multicenter phase 1 clinical trial presented today at the 2015 San Antonio Breast Cancer Symposium show that the anti-androgen agent enzalutamide is active and well-tolerated alone and with fulvestrant in patients with advanced breast cancer. The study takes another important step toward larger clinical trials targeting androgen receptors in breast cancer.http://medicalxpress.com/news/2015-12-phase-results-larger-trial-enzalutamide.html
CancerMon, 07 Dec 2015 15:52:09 ESTnews368725922Prostate cells undergo 'reprogramming' to form tumors, study findsScientists have gained a key insight into how prostate tumors get their start - not by rewriting the normal DNA code, but by reprogramming the master regulator of genes in prostate cells to drive malignant growth.http://medicalxpress.com/news/2015-10-prostate-cells-reprogramming-tumors.html
CancerMon, 12 Oct 2015 11:00:01 ESTnews363866388Low T not just in males: Testosterone, atherosclerosis, obesity may be linked in femalesWhile testosterone replacement therapies may be controversial in males, new research in The FASEB Journal may extend this controversy to females too. That's because research involving mice, appearing in the April 2015 issue, suggests that there is an association between low levels of androgens (which includes testosterone), and atherosclerosis and obesity in females.http://medicalxpress.com/news/2015-04-males-testosterone-atherosclerosis-obesity-linked.html
Medical researchWed, 01 Apr 2015 15:46:19 ESTnews347121969Even low-androgen triple-negative breast cancer responds to anti-androgen therapyA University of Colorado Cancer Center study published today in the journal Molecular Cancer Therapeutics shows that only about 1 percent of triple-negative breast cancer cells in a tumor must be "androgen-receptor-positive" to show benefit from anti-androgen therapies. There are no FDA-approved targeted therapies for triple-negative breast cancer. Clinical trials currently underway are showing promising preliminary results of anti-androgen-receptor therapies against triple-negative breast cancers expressing a higher percentage of androgen-receptor-positive cells.http://medicalxpress.com/news/2015-02-low-androgen-triple-negative-breast-cancer-anti-androgen.html
CancerTue, 24 Feb 2015 13:00:41 ESTnews344005230Androgen receptor abnormality may not be associatedFindings from a small prospective study suggest that androgen receptor V7 (or AR-V7) status does not significantly affect response to taxane chemotherapy in men with metastatic castration-resistant prostate cancer (mCRPC). Treatment outcomes were largely similar for the 17 patients with AR-V7-positive prostate cancer and the 20 patients with AR-V7-negative disease included in this analysis. The study will be presented at the upcoming 2015 Genitourinary Cancers Symposium in Orlando.http://medicalxpress.com/news/2015-02-androgen-receptor-abnormality.html
CancerTue, 24 Feb 2015 09:58:36 ESTnews343994306Prostate cancer: Androgen receptor activates different genes when bound to antiandrogensThe androgen receptor in prostate cancer cells can activate different sets of genes depending on whether it binds with an androgen hormone or an antiandrogen drug, according to a new study led by researchers at The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC - James).http://medicalxpress.com/news/2015-01-prostate-cancer-androgen-receptor-genes.html
CancerTue, 27 Jan 2015 12:26:09 ESTnews341583960Three San Antonio studies target androgen in breast cancerThree studies presented by University of Colorado Cancer Center researchers at the San Antonio Breast Cancer Symposium 2014 demonstrate the effects of blocking androgen receptors in breast cancer. One shows that, counterintuitively, blocking the action of androgen receptors reduces the growth of estrogen-positive (ER+) breast cancers. The second study found that even triple-negative breast cancers (TNBCs), which are without known hormone drivers and carry the poorest prognosis, are dependent on androgen receptor activation. And the third study finds that targeting androgen receptors along with known cancer drivers HER2 or mTOR has a synergistic effect in which more cancer cells are killed by the combination than the sum of the cells killed by both drugs, combined.http://medicalxpress.com/news/2014-12-san-antonio-androgen-breast-cancer.html
CancerThu, 11 Dec 2014 09:40:12 ESTnews337513205Galeterone shows activity in a variant form of castration-resistant prostate cancerResults from a trial of the anti-cancer drug galeterone show that it is successful in lowering prostate-specific antigen (PSA) levels in men with a form of prostate cancer that is resistant to treatment with hormone therapy (castration-resistant prostate cancer or CRPC).http://medicalxpress.com/news/2014-11-galeterone-variant-castration-resistant-prostate-cancer.html
CancerTue, 18 Nov 2014 18:00:02 ESTnews335552679Target identified for rare inherited neurological disease in menResearchers at University of California, San Diego School of Medicine have identified the mechanism by which a rare, inherited neurodegenerative disease causes often crippling muscle weakness in men, in addition to reduced fertility.http://medicalxpress.com/news/2014-08-rare-inherited-neurological-disease-men.html
NeuroscienceSun, 10 Aug 2014 13:00:07 ESTnews326824742Possible new weapon found for fighting some types of breast cancerResearchers believe they have discovered one reason why some women with estrogen receptor-positive breast cancer may respond poorly or only temporarily to estrogen-blocking drugs such as tamoxifen. Results of a new study, which was presented Saturday at the joint meeting of the International Society of Endocrinology and the Endocrine Society: ICE/ENDO 2014 in Chicago, point to a previously unrecognized role of the androgen receptor.http://medicalxpress.com/news/2014-06-weapon-breast-cancer.html
CancerMon, 23 Jun 2014 10:03:41 ESTnews322736610Team find new targets that could increase effectiveness of breast cancer treatmentsScientists from the Florida campus of The Scripps Research Institute (TSRI) have found new targets for potential intervention in breast cancer. These new targets could eventually increase effectiveness and reduce the undesirable side effects associated with current treatments.http://medicalxpress.com/news/2014-06-team-effectiveness-breast-cancer-treatments.html
CancerThu, 05 Jun 2014 17:27:06 ESTnews321208015New target for prostate cancer resistant to anti-hormone therapiesProstate cancer becomes deadly when anti-hormone treatments stop working. Now a new study suggests a way to block the hormones at their entrance.http://medicalxpress.com/news/2014-04-prostate-cancer-resistant-anti-hormone-therapies.html
CancerWed, 23 Apr 2014 13:00:03 ESTnews317472763Targeting metabolism to develop new prostate cancer treatmentsA University of Houston (UH) scientist and his team are working to develop the next generation of prostate cancer therapies, which are targeted at metabolism.http://medicalxpress.com/news/2014-02-metabolism-prostate-cancer-treatments.html
CancerFri, 28 Feb 2014 03:07:03 ESTnews312779200Study identifies a key cellular pathway in prostate cancerMayo Clinic researchers have shed light on a new mechanism by which prostate cancer develops in men. Central to development of nearly all prostate cancer cases are malfunctions in the androgen receptor—the cellular component that binds to male hormones. The research team has shown that SPOP, a protein that is most frequently mutated in human prostate cancers, is a key regulator of androgen receptor activity that prevents uncontrolled growth of cells in the prostate and thus helps prevent cancer. The findings appear in the journal Cell Reports.http://medicalxpress.com/news/2014-02-key-cellular-pathway-prostate-cancer.html
CancerMon, 10 Feb 2014 14:53:54 ESTnews311266416Doctors help Israeli combat soldier with testosterone disorder start a familyDr. Karen Tordjman, a senior lecturer at Tel Aviv University's Sackler Faculty of Medicine didn't have an immediate diagnosis for the under-masculinized young man who walked into her office. A 25-year-old university student who had served in an elite commando unit in the Israeli navy, he was handsome in a fashion-model kind of way: rail thin, with a smooth face and delicate, feminine features. Closer inspection revealed no body hair other than sparse patches in his armpits and groin. His genitals were small and heavily scarred.http://medicalxpress.com/news/2013-10-doctors-israeli-combat-soldier-testosterone.html
Diseases, Conditions, SyndromesFri, 11 Oct 2013 08:30:02 ESTnews300696901Team finds potential clue associated with aggressive prostate cancerProstate cancer is one of the most common forms of cancer in men and the leading cause of cancer deaths in white, African-American and Hispanic men, according to the Centers for Disease Control. Current treatment of prostate cancer targets androgens, hormones which promote the growth and spread of cancer cells. However, it remains unclear why, despite treatment, some prostate cancers progress and may become fatal. Researchers at Robert Wood Johnson Medical School, part of Rutgers, The State University of New Jersey, who are studying the underlying mechanisms that cause invasive tumor growth have identified a key transcription factor, a protein which regulates the flow of information from DNA, that is over-produced in treatment-resistant prostate cancer, as well as the two protein kinases that trigger the process.http://medicalxpress.com/news/2013-08-team-potential-clue-aggressive-prostate.html
CancerTue, 20 Aug 2013 07:55:03 ESTnews296204081Targeting aggressive prostate cancerA team of researchers from UC Davis, UC San Diego and other institutions has identified a key mechanism behind aggressive prostate cancer. Published on August 14, 2013 in Nature, the study shows that two long non-coding RNAs (PRNCR1 and PCGEM1) activate androgen receptors, circumventing androgen-deprivation therapy. In their active state, these receptors turn on genes that spur growth and metastasis, making these cancers highly treatment-resistant. The study illustrates how prostate cancer can thrive, even when deprived of hormones, and provides tempting targets for new therapies.http://medicalxpress.com/news/2013-08-aggressive-prostate-cancer.html
CancerWed, 14 Aug 2013 13:00:03 ESTnews295672709New approach for late-stage prostate cancer(Medical Xpress)—For the past 70 years, androgen deprivation therapy (ADT) has been the standard treatment for men diagnosed with late-stage prostate cancer.http://medicalxpress.com/news/2013-06-approach-late-stage-prostate-cancer.html
GeneticsFri, 14 Jun 2013 07:00:06 ESTnews290411998New direction for prostate cancer research a world firstResearchers at the University of Adelaide are spearheading a new direction in prostate cancer research, with the potential for new treatments of the disease.http://medicalxpress.com/news/2013-06-prostate-cancer-world.html
CancerMon, 03 Jun 2013 07:20:02 ESTnews289461792Small molecule could have big impact on cancerDr. Jung-Mo Ahn, associate professor of chemistry at The University of Texas at Dallas, has designed and synthesized a novel small molecule that might become a large weapon in the fight against prostate cancer.http://medicalxpress.com/news/2013-05-small-molecule-big-impact-cancer.html
CancerTue, 28 May 2013 16:18:04 ESTnews288976675