The script for "Genesis" describes Barclay as, "a horrible cross between human and SPIDER. His EYES are black and bulbous -- and he has three smaller EYES growing out of his forehead. His skin is mottled with distinctive colorations and hairy CILIA. His hands are completely unrecognizable -- hooked and terrible." [1]

A scene featured in the script for "Suddenly Human" but changed in the finished episode, describes Jono as being, "suspended from the ceiling in a spider-web hammock." [2]

In the script for "Imaginary Friend", the attack on the USS Enterprise-D at the end of the episode is described as, "The ship is immersed in an astounding amount of ENERGY STRANDS -- ten times as many. They surround the ship like a spider's web -- tendrils draped over the ship, tangling it deeper..." [3]

During the scene in which the USS Rubicon is affected by a plasma storm in "Hippocratic Oath", the script describes the field as, "a SPIDER WEB of SPIKY BLUE ENERGY spreads across the front window like a net."

The Star Trek Cookbook features the Tashmanian spider (β), a Klingon spider found on the planet Qo'noS. Considered a delicacy among Klingons, they are said to be tough enough to survive being boiled in fat.