Although very influential within modern sociology, the sociology of knowledge can claim its most significant impact on science more generally through its contribution to debate and understanding of the nature of science itself, most notably through the work of Thomas Kuhn on The structure of scientific revolutions (see also: paradigm).

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The German political philosophers Karl Marx (1818–1883) and Friedrich Engels (1820–1895) argued in Die Deutsche Ideologie (1846, German Ideology) and elsewhere that people's ideologies, including their social and political beliefs and opinions, are rooted in their class interests, and more generally in the social and economic circumstances in which they live: "It is men, who in developing their material inter-course, change, along with this their real existence, their thinking and the products of their thinking. Life is not determined by consciousness, but consciousness by life" (Marx-Engels Gesamtausgabe 1/5).

Under the influence of this doctrine, and of Phenomenology, the Hungarian-born German sociologist Karl Mannheim (1893–1947) gave impetus to the growth of the sociology of knowledge with his Ideologie und Utopie (1929, translated and extended in 1936 as Ideology and Utopia), although the term had been introduced five years earlier by the co-founder of the movement, the German philosopher and social theorist Max Scheler (1874–1928), in Versuche zu einer Soziologie des Wissens (1924, Attempts at a Sociology of Knowledge). Mannheim feared that this interpretation could be seen to claim that all knowledge and beliefs are the products of socio-political forces since this form of relativism is self-defeating (if it is true, then it too is merely a product of socio-political forces and has no claim to truth and no persuasive force). Mannheim believed that relativism was a strange mixture of modern and ancient beliefs in that it contained within itself a belief in an absolute truth which was true for all times and places (the ancient view most often assoicated with Plato) and condemned other truth claims because they could not achieve this level of objectivity (an idea gleaned from Marx). Mannheim sought to escape this problem with the idea of 'realtionism'. This is the idea that certain things are true only in certain times and places (a view influenced by pragmatisim) however, this does not make them less true. Mannheim felt that a srata of free-floating intellectuals (whom he claimed were only loosely anchored to the class structure of society) could most perfectly realise this form of truth by creating a "dynamic synthesis" of the ideologies of other groups.

Based on the work of Edmund Husserl's philosophical phenomenology, Alfred Schutz proposed a micro-sociological approach also known as phenomenology. Schutz looked at the way in which ordinary members of society consitute and reconstitute the world in which they live; life world.

For Schutz, it was important to bracket one's taken-for-granted assumptions about the life in order to properly understand the life world of those being researched.

A particularly important strain of the sociology of knowledge is the criticism by Michel Foucault. In Madness and Civilization: A History of Insanity in the Age of Reason, 1961, he argued that conceptions of madness and what was considered "reason" or "knowledge" was itself subject to major culture bias - in this respect mirroring similar criticisms by Thomas Szasz, at the time the foremost critic of psychiatry, and himself now an eminent psychiatrist. A point where Foucault and Szasz agreed was that sociological processes played the major role in defining "madness" as an "illness" and prescribing "cures".

Perhaps Foucault's best-known and most controversial claim was that before the 18th century, "Man did not exist". The notions of humanity and of humanism were inventions or creations of this 19th century transformation. Accordingly, a cognitive bias had been introduced unwittingly into science, by over-trusting the individual doctor or scientist's ability to see and state things objectively. This study still guides the sociology of knowledge and has been claimed to have sparked single-handedly much of postmodernism.

Studies of mathematical practice and quasi-empiricism in mathematics are also rightly part of the sociology of knowledge, since they focus on the community of those who practice mathematics and their common assumptions. Since Eugene Wigner raised the issue in 1960 and Hilary Putnam made it more rigorous in 1975, the question of why fields such as physics and mathematics should agree so well has been in question. Proposed solutions point out that the fundamental constituents of mathematical thought, space, form-structure, and number-proportion are also the fundamental constituents of physics. It is also worthwhile to note that physics is nothing but a modeling of reality, and seeing causal relationships governing repeatable observed phenomena, and much of mathematics has been developed precisely for the goal of developing these models in a rigorous fashion. Another approach is to suggest that there is no deep problem, that the division of human scientific thinking through using words such as 'mathematics' and 'physics' is only useful in their practical everyday function to categorify and distinguish.

Fundamental contributions to the sociology of mathematical knowledge have been made by Sal Restivo and David Bloor. Restivo draws upon the work of scholars such as Oswald Spengler (The Decline of the West, 1926), Raymond L. Wilder and Lesley A. White, as well as contemporary sociologists of knowledge and science studies scholars. David Bloor draws upon Ludwig Wittgenstein and other contemporary thinkers. They both claim that mathematical knowledge is socially constructed and has irreducible contingent and historical factors woven into it. More recently Paul Ernest has proposed a social constructivist account of mathematical knowledge, drawing on the works of both of these sociologists.

An interesting artifact in the sociology of knowledge is the Erdős number (the length of the smallest path in the network of all mathematicians to Paul Erdős).