As known disease-associated variants identified through
large cohort-based studies often explain only a small percentage
of genetic risk in multifactorial disorders such as
multiple sclerosis (MS), alternative methods ...

Within-population genetic diversity is greatest within Africa, while between-population genetic diversity is directly
proportional to geographic distance. The most divergent contemporary human populations include the ...

Approximately 25 % of clinically important drugs and numerous environmental carcinogens are metabolised by CYP2D6. Variation in the CYP2D6 gene and concomitant use of tamoxifen (TAM) with certain antidepressants may increase ...

The first case of malacoplakia known to have affected the female genital tract is presented. This lesion involved the upper vagina and presented clinically as an infiltrating carcinoma. No evidence of malacoplakia of the ...

Authors report the management of a case of malignant trophoblastic disease which presented initially as a haematemesis and melaena from a gastric metastasis. The patient had had a tubal sterilization 4 years previously. ...

A metastatic tumour growing in the heart more than 2 years after total removal of the primary hepatic growth is a rare event. Jaundice as a result of bile production by the metastasis is most unusual. The primary tumour ...

Two cases of Kawasaki disease, both with cardiac involvement.
are reported in South African children and
the diagnostic problems are discussed. In patient 1 an
ECG showed the development of an .inferior myocardial
infarction, ...

Two young White brothers had dilated (congestive) cardiomyopathy. The elder came to autopsy after a chronic course of congestive cardiac failure; the younger underwent repeated cardiac catheterization and transvenous right ...

Hearts from 32 patients with idiopathic cardiomyopathy were examined postmortem. A comparative morphological study of the human hearts and of hearts from cardiomyopathic hamsters, rabbits and baboons indicates that severe ...