..Abnormal motor posturing is often observed in children with cerebral malaria, but the aetiology and pathogenesis is poorly understood. This study examined the risk factors and outcome of posturing in Kenyan children with cerebral malaria...

The prognostic value of measures of acid/base balance in pediatric falciparum malaria, compared with other clinical and laboratory parameters

..The coinfection of malaria and HIV-1 may aggravate the neurodevelopmental impairments documented in these children. However, to date there are little published data, although it may have a profound effect of children living in SSA...

..The method has been successfully applied to a pharmacokinetic study of LZP in children with severe malaria and convulsions following administration of a single intravenous dose (0.1 mg/kg body weight) of LZP...

Management of severe malaria in children: proposed guidelines for the United Kingdom

..The method was successfully applied to a pharmacokinetic study of MDZ and 1'-OHM in children with severe malaria and convulsions following administration of MDZ either intravenously (i.v.) or intramuscularly (i.m.)...

Both heterozygous and homozygous alpha+ thalassemias protect against severe and fatal Plasmodium falciparum malaria on the coast of Kenya

..The figure is likely to be considerably higher, since these estimates do not include neurocognitive impairment following non-cerebral malaria in children or adults in stable endemic areas, or populations in low stable or epidemic areas...

Indicators of acute bacterial meningitis in children at a rural Kenyan district hospital

James A BerkleyCentre for Geographic Medicine Research Coast, Kilifi, KenyaPediatrics 114:e713-9. 2004

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Use of clinical syndromes to target antibiotic prescribing in seriously ill children in malaria endemic area: observational study

..This review addresses recent developments that relate to the pathogenesis of severe malaria and its treatment, and also highlights the increase in the global burden of malaria and provides a summary of clinical trials of malaria vaccines...

..04) was associated with significantly increased odds of an impairment-level score relative to the unexposed group. The results suggest that falciparum malaria is one of the most common causes of acquired language disorders in the tropics...

Neuro-cognitive impairment following acquired central nervous system infections in childhood: a systematic review

..Higher morbidity for similar mortality in acute bacterial meningitis compared with cerebral malaria in the epidemiological data may suggest future research directions for clinical research to devise more effective interventions...

Oxidative stress and erythrocyte damage in Kenyan children with severe Plasmodium falciparum malaria

..In addition, new antimalarial agents have been examined worldwide and initial studies on supportive studies conducted. This paper reviews these new advances, putting them into the perspective of the more established knowledge...

Using community/researcher partnerships to develop a culturally relevant intervention for children with communication disabilities in Kenya

..This study provides evidence that axonal injury is associated with malaria coma and identifies the potential role of severe anaemia, acidosis and hyperparasitaemia to causing brain parenchymal damage in children with malaria...

..Acute bacterial meningitis (ABM) is an important cause of mortality in Africa, but most studies are based in urban referral hospitals. Poor laboratory facilities make diagnosis difficult, and treatment is limited to inexpensive antibiotics...

Antibodies to voltage-gated calcium channels in children with falciparum malaria

..Thus, leucocytosis was associated with both severity and mortality in children with falciparum malaria, irrespective of bacteraemia, whereas thrombocytopenia, although very common, was not associated with adverse outcome...

Determination of paraldehyde by gas chromatography in whole blood from children

..The age-dependent Epo response to anemia and the age-dependent protective effect may influence the clinical epidemiology of CM. These data support further study of Epo as an adjuvant therapy in CM...

Over-diagnosis and co-morbidity of severe malaria in African children: a guide for clinicians

..Since NS is common in resource poor countries, this may be an important cause of neuro-developmental impairment in children living in this setting...

Immunization coverage and risk factors for failure to immunize within the Expanded Programme on Immunization in Kenya after introduction of new Haemophilus influenzae type b and hepatitis b virus antigens

..Haemophilus influenzae type b (Hib) conjugate vaccine is not perceived as a public health priority in Africa because data on Hib disease burden and vaccine effectiveness are scarce. Hib immunization was introduced in Kenyan infants in 2001...

Children with severe malnutrition: can those at highest risk of death be identified with the WHO protocol?