Publication History

Significance

The psychotropic, antiemetic, analgesic, and anticonvulsant properties
of Cannabis plants have been known since
the third millennium BC. Cannabinoids target two cell receptors:
the central cannabinoid receptor CB1 and the peri­pheral
cannabinoid receptor CB2. A [2+2+2] cyclo­trimerization
reaction gave access to three different cannabinoid analogues from
the same intermediate, providing a flexible synthetic route.