Can you wait about 10-15 seconds, let the 'loading' spins. It might look as if nothing is happening but give it some time and the black box should appear and the game should start. I've just tested it (x64 version) and it runs. Let me know if it doesn't work for you still.

Uhhh yup. Tried again and I actually waited for a full three minutes without generating any further input while it was loading just now. Nothing went wrong when I was extracting the files or anything. I'm running the latest release of DX 11 by default, and it doesn't look like I can run the DX 9 file attached to the game.

I'm not a programmer by any means, so forgive me if what I'm saying doesn't make any sense at all. I've also tried running the 32 bit version with the same issue.

OK, let's try a few things. First, do you have an antivirus? That might prevent start of the executable. Start the Task Manager, then start the game. In Task Manager, look for lupus.exe, whether the process appears at all or whether it is terminated. In case AVirus program is messing it, you will have to put the executable in 'allowed' exceptions.As of DX, Win10 should have already DX9 components, you can try just in case this link- https://www.microsoft.com/en-us/download/details.aspx?id=8109 (scroll a bit down, there's a download button). DX installer will determine if anything is amiss or reinstall if anything is damaged (it won't mess up your current DX), watch for the message what it tells you and report back.

Oh, thank Hefns, and there I thought I would have to call the 'olde Gods' for support as I was starting to worry. :D

Well, glad to see it works, but make sure to open your AntiVirus program and put Lupus.exe in Exception list (they all have some, sometimes called 'Whitelist' as well) so you don't have to repeat the disabling operation every time you start the game.