The Guillermo Álvarez Guedes Collection contains audiovisual materials and manuscripts of the Cuban comedian and performer Guillermo Álvarez Guedes active from the 1960s to the early 2000s.

The collection contains videos, cassette tapes and CDs of Guillermo Álvarez Guedes' comedic performances. The collection also includes manuscripts for books including Cadillac; and scripts for radio shows and live performances. It also includes, ephemera, posters, clippings, musical arrangements, and photo albums documenting Álvarez Guedes' career.