Dialectical Behavior Therapy (DBT) and Acceptance and Commitment Therapy (ACT) are both innovative behavioral treatments that incorporate mindfulness practices and acceptance-based interventions into their treatment packages. Although there are many similarities between these treatments, including the fact that they are part of a newer wave in behavior therapy involving mindfulness and acceptance interventions, there also are some key differences in the ways in which ACT and DBT conceptualize and use acceptance and mindfulness interventions in treatment. This article discusses these similarities and differences.