For the Consumer

In addition to its needed effects, some unwanted effects may be caused by guaifenesin / hydrocodone. In the event that any of these side effects do occur, they may require medical attention.

You should check with your doctor immediately if any of these side effects occur when taking guaifenesin / hydrocodone:

Incidence not known

Difficult or troubled breathing

irregular, fast or slow, or shallow breathing

pale or blue lips, fingernails, or skin

shortness of breath

Some of the side effects that can occur with guaifenesin / hydrocodone may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common

Diarrhea

dizziness

feeling of warmth

headache

nausea

redness of the face, neck, arms, and occasionally, upper chest

sleepiness or unusual drowsiness

sudden sweating

For Healthcare Professionals

Nervous system

One study has suggested that the respiratory depression caused by hydrocodone may be of benefit in the treatment of dyspnea related to chronic obstructive pulmonary disease and restrictive lung disease. However, the potential for the precipitation of respiratory insufficiency makes such use of hydrocodone hazardous and such use should be undertaken, if at all, only with extreme caution.[Ref]

Nervous system side effects of guaifenesin have included dizziness and headache. Central nervous system adverse effects of hydrocodone have included mental depression, dizziness, lightheadedness, respiratory depression (which is sometimes fatal), stupor, delirium, somnolence, agitation, and dysphoria.[Ref]

Other

Other side effects of hydrocodone have included withdrawal symptoms, such as agitation, restlessness, anxiety, insomnia, tremor, abdominal cramps, blurred vision, vomiting and sweating, after either abrupt cessation or fast tapering of narcotic analgesics.[Ref]

Gastrointestinal

Gastrointestinal side effects of guaifenesin have included upset stomach and vomiting with higher than recommended doses. Doses recommended for expectoration are rarely associated with gastrointestinal upset. Gastrointestinal side effects of hydrocodone have included nausea, vomiting, constipation, and dry mouth.[Ref]

Genitourinary

Genitourinary side effects of hydrocodone have included ureteral spasm, spasm of vesicle sphincters, and urinary retention.[Ref]

Dermatologic

Dermatologic side effects of guaifenesin have included rash. Narcotic-induced rash has also been reported.[Ref]

Professional resources

Related treatment guides

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