The digital revolution in cancer. Is a fully functional digital twin a reality in oncology?

Key points

The world of medicine needs a different alternative without causing harm to patients whilst also providing a platform for better healthcare from physicians.

The speed of which digital science within healthcare is quickly progressing gives the presumption that an answer is not far away and what is ever more promising is that it is showing no signs of slowing down.

A Digital twin is referred to as a digital replica of physical assets (physical twin), processes, people, places, systems and devices that can be used for various purposes to run simulations without the disruption of equipment or harm to individuals. Within healthcare a “digital twin” would ideally be a real life replica of a human body which shows all physiological, pathological outcomes in the present and future, all mapped out in a highly detailed visual.

The reality however is this process is currently premature and consist of a complex network of statistics, genetic pathways and possible outcomes amongst many others, in which only trained professionals would be able to interpret. The “Digital Twin” concept would be applied to enable personalised medical treatments in areas currently needing much more research such as Oncology but to also enable collaborative data to be researched and determine successful treatment, and pathological diagnostic problems and help aid with diagnostic by running treatment simulations without harming the patients.

Is a realistic digital twin within oncology achievable?

The ultimate goal is to encompass numerous current AI concepts to work in synchronisation to enable the development of a fully functioning digital twin. In an ideal world If data and technology was shared amongst leading players in Artificial intelligence to create a realistic model then, in theory, this would be highly achievable within the next 5 years. The reality however is that currently it is very futuristic. There are however two initiative currently in development, one in Europe, the digitwins initiative and one In china, the 12sigma project.

This workshop is designed to support the growth and adoption of digital twin technology in healthcare, Pharmaceuticals and hospital management.

Created for the industry, Challenge Advisory is presently working with 30 members of their steering committee to build a framework and agenda to build upon the work they have already done, to develop the value of Digital Twins.

Firstly the Digitwins initiative, which is a collective of over 200 partners from 29 different countries, which has the potential to receive 10 billion euros in funding over a period of ten years. With the aim to develop a revolutionary approach to healthcare based on detailed modelling systems, which would enable various treatment simulations to be run without any harm to the patient. They are planning on running the first pilot schemes soon, including one in the Internet of things (IOT) which will hopefully enable the project to be taken to the next level. One of the main aims in relation to oncology is to change and energise biomedical research and clinical practice via developing novel modelling, diagnostic and therapeutic technologies to not only increase patient well being but also save the ever expanding healthcare budgets throughout europe. They are also addressing one of the main dilemmas of production a data driven digital twin via resourcing a lot of their research into data protection and how the project can ensure all patient data is is governed to ensure full protection.

The 12Sigma company are one of the first companies to combine Artificial intelligence and deep learning to produce medical image diagnostics and in depth medical data analysis. Deep learning software, simply put, tries to mimic the activity within human neurons via usage of algorithms inspired by the human brain to enable it to learn by experience and develop skills without human interference. 12Sigma uses deep learning networks to seek out numerous diseases whilst simultaneously providing insights into other areas such as early and rare disease detection and treatment planning and patient monitoring. 12sigmas deep learning product enables doctors to interpret challenging medical cases. In regards to cancer is is believed to be able to detect tiny lesions as small as 0.01% of an image and achieve a 98.5% accuracy rating. This product is the first of its kind on the market. It is not only there deep learning platform that is revolutionary, their medical data analysis platforms perform outstandingly in precision medicine, genome sequencing and pathological analysis, which help aid in disease diagnostics, especially in cancer. They also provide a cloud platform in which doctors can interact and help them provide accurate and precise diagnosis, regardless of where the patient is located. Developmental updates have been slow from them, presumably due to privacy in an ever expanding market. Regardless, the work they have done so far is groundbreaking and could only open more doors towards the development of a fully functioning digital twin.

Professor Yu Feng, of The School of chemical engineering Oklahoma state University, has computerised an in-silico hypothetical digital twin. Not using data derived from a live human, but a virtual human system. Using computational fluid-particle dynamics (CFPD) simulations to determine if the target area can be decreased and increase in concentrated drug dose via inhalation can be achieved. Using multi-modeling framework Dr Yeng hypothesised, that the use of a fully digitised twin to increase the drug delivery on the target area via aerosol inhalation of chemotherapeutic agents increased from 20% to nearly 90% via visual determination of where to target could potentially improve the prognosis for thousands of cancer patients across the globe. (image courtesy of fung et al, 2018).

Other prospects in digital development

There are however some modelling systems in place that if you used in conjunction to one another, increases the likelihood of making a digital twin achievable. A first point of call could be the Virtual Physiological Human (VPH), which is currently under production at the The Virtual Physiological Human Institute for Integrative Biomedical Research, in Belgium. They describe the VPH as “A world-wide community that aims to create validated in-silico models of human health and disease via the use of individualised physiology based computer simulations in all aspects of the prevention, diagnosis, prognostic assessment, and treatment of a disease and development of a biomedical product”. VPH has 3 main targets; (1) the digital patient (VPH for doctors); (2) in silico clinical trials (VPH for the biomedical and pharma industry; and (3) personal health forecasting (VPH for the patient/citizen).

All 3 targets can be correlated back to Oncology to enable efficient visualisation of the patient and determine specific outcomes, not only of pharmacological outcome but if patients are not responding to conventional treatments, then you could hypothetically simulate the outcome of a treatment via a clinical trial before putting them at any risk, which aids the argument towards the ethical implications of Digital twins.

VPH can currently be used to detect all 3 targets within HIV, Cardiovascular issues and musculoskeletal issues, therefore it would surely have the parameters to enable it to target oncology?

If VPH was paired with a huge database such as IBM’s Watson, which is an integrated database programme, in which it extracts key attributes from an individual patient’s medical record, via language processing to understand all patient data when integrated with the electronic medical records. It can then provide evidence based treatment recommendations via combining information with training from the memorial sloan kettering cancer centre (MSK) to provide ranked treatment options with supporting evidence from over 300 medical journals, over 250 textbooks and 15 million pages of text to enable the treating Physician to provide expert, up to date care.

Another recently published modelling system used in cancer progression, which could be hypothetically paired with a system such as VPH is the REVOLVER model, from the Institute of Cancer Research. It does not possess its own interface, and the script is run on the open access R statistical Software system. It works via multiple patient evolutionary models aiming to increasing their tumour structural correlation to highlight hidden evolutionary patterns. Its validity is increased due to it being able to run both binary and CCF values within tree phylogeny to detect tumour evolution. Although still premature it is a very thorough indicator of tumour progression. If either model could be incorporated into a virtual Human then it is plausible that they could work in conjunction to help determine medical outcomes without any harm to the patient.

Implementation of a database and a virtual twin could be the initial building blocks for the desired result of a fully fledged digital twin, there are however many issues in which a project like that should need to overcome. Firstly within oncology, there are numerous signalling pathways and cellular mechanisms, most of which are not still fully understood, if at all, which would make disease progression and outcome hard to validate, secondly you have to have as much data as possible in regards to the microbiome, pharmacogenetics and an extensive tissue bank database to be able to determine all outcomes. Which asks the question, are there too many human factors involved to create a complete one? Would modelling certain aspects be more efficient?

For example if you model the cardiovascular system of a patient and locate the tumour, could you then run successful simulations of drug trials and look at disease progression? Currently digital twins of specific systems make more sense as there is already the foundations there to enable this. But with 200,000 cases of adverse drug reactions in the last year alone throughout Europe, half of which are attributed to cancer, and resistance of chemotherapeutic drugs more apparent. The world of medicine needs a different alternative without causing harm to patients whilst also providing a platform for better healthcare from physicians. The speed of which digital science within healthcare is quickly progressing gives the presumption that an answer is not far away and what is ever more promising is that it is showing no signs of slowing down.