This June 23 issue of The Lancet falls on the second anniversary since the UK European Union (EU) membership referendum altered the course of European history: throwing prospects for health, medicine, and scientific research into uncertainty against a backdrop of heightened feelings. 2 years later, few bodies have clear plans for their post-Brexit strategies. The European Medicine Agency’s building relocation from London to Amsterdam is on track for completion by March, 2019, but the agency has made no progress towards redefining its relationship with the UK.