central NPFF1 (show NPFFR1 ELISA Kits) and NPFF2 receptors control in an opposite manner the body temperature in mice.

species-related differences in the binding properties of NPFF(2) receptors

The distribution pattern of NPFF2 receptors in the diencephalon and the superficial layers of the spinal cord is consistent with a hypothesized potential role for NPFF in the modulation of sensory input and opioid analgesia.

Neuropeptide FF Receptor 2 (NPFF2) Antigen Profile

Antigen Summary

This gene encodes a member of a subfamily of G-protein-coupled neuropeptide receptors. This protein is activated by the neuropeptides A-18-amide (NPAF) and F-8-amide (NPFF) and may function in pain modulation and regulation of the opioid system. Alternative splicing results in multiple transcript variants.