Quantitative analysis of brain and structures in it, in terms of volume, weight and density, in patients with severe brain trauma, using MALUNA dedicated software to process DICOM images.

st endpoint: compare these data with those obtained by CT scans analysis of patients that recur to this kind of diagnostic investigation for non-traumatic events and with negative diagnostic related to cerebral pathological implication.

rd endpoint: evaluate differences in terms of volume, weight and density of brain and its structures, between patients with diffuse cerebral injury and those with localized lesions.

Eligibility

Ages Eligible for Study:

18 Years and older

Genders Eligible for Study:

Both

Accepts Healthy Volunteers:

No

Sampling Method:

Probability Sample

Study Population

Male and female, any ethnic group with severe brain trauma

Criteria

Inclusion Criteria:

Male and female, any ethnic group

Patient with severe brain trauma (GCS < 8)

Need of mechanical ventilation

Clinical need of urgent CT study of brain.

Need of clinical control of CT study of brain within first 72 hours from event

Informed consent obtained from solicitor, due to the fact that patient is

Exclusion Criteria:

Age minor than 18 yrs old at hospitalization day

Cardiac arrest pre-hospital or in-hospital and post-anoxic coma

Non traumatic coma

Exaggerated ingestion of depressors of central nervous system

Documented abuse of narcotic drugs;

Documented abuse of alcohol

Contacts and Locations

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study.
To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below.
For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01990963