The Concentration-Dependent effect & having post-antibiotic effect means what for the amount of doses needed to be given in a day for Aminoglycosides?

Only need a single daily dose (not Time-Dependent!) so can ↓ frequency of administration (owners like this)

How does the pH affect aminos?

↑ the pH (more basic) will ↑ the antimicrobial activity (acidic pH will ↓ activity) (Ami is a Basic bitch, she likes the basic shit)

presence of Ca or Mg cations also decrease

**How do you administer aminos?

100% PARENTERAL ABSORPTION! (Oral absorption is shitty) (AMI is like the sultan → she is special, so only takes the strange ways into a building)

complete and rapid absorption in ear and eyes

Where do aminos accumulate? (Intra or extra cellularly?)

Extra (Ami likes extra things)

Where are aminos metabolized?

They arent metabolized(lol Amy has no metabolism, I guess she's fat then)

How is the distribution of aminos in lean versus fat animals?

↑ distribution in lean animals (I'm not clear on WHY but she & all the textbooks say this is right)slow tissue depletion

**What are the toxicities caused by aminos? (3)

(1) Nephrotoxicities(2) Ototoxicity inner ear, irreversible --> Perilymph and endolymph(3) Neuromuscular blockade(Ami's kidneys are probably shot, as well as her hearing, & by the way she dances youd think she had a neuromuscular problem too)