The term "adrenal fatigue", which was coined in 1998 by James Wilson, a chiropractor,[3] may be applied to a collection of mostly nonspecific symptoms.[1] There is no scientific evidence supporting the concept of adrenal fatigue and it is not recognized as a diagnosis by the medical community.[1][2]

Blood or salivary testing is sometimes offered but there is no evidence that adrenal fatigue exists or can be tested.[1][3] The concept of adrenal fatigue has given rise to an industry of dietary supplements marketed to treat this condition. These supplements are largely unregulated in the U.S., are ineffective, and in some cases may be dangerous.[3]