California Hotel Reservations

Hotels in Vacaville, CA

Nestled neatly along Interstate 80, Vacaville is only 35 miles south of Sacramento and 45 miles north of San Francisco – it's a premier location in Gold Country. Vacaville is home to major biotechnology and pharmaceutical companies like Genentech, ALZA Corporation, Novartis International AG, and Kaiser Permanente.

Visitors enjoy attending Downtown Vacaville'sCreekwalk, featuring a seasonal farmer's market and the Town Square Project. Check out the Vacaville Museum to explore some local history – where admission is only $1 for students. Before leaving Vacaville, you can't miss the Lagoon Valley/Pena Adobe Regional Park for some fishing in Lagoon Valley Lake, or an exploration of the Pena Adobe home and the Goheen-Mowers Museum.