Supplementation with the antioxidant lycopene significantly decreases oxidative stress parameters and the bone resorption marker N-telopeptide of type I collagen in postmenopausal women

Abstract

Summary

To date, no intervention studies have been published demonstrating the effect of the antioxidant lycopene on bone. Postmenopausal women supplemented with lycopene had significantly increased antioxidant capacity and decreased oxidative stress and the bone resorption marker N-telopeptide (NTx). Lycopene decreases bone resorption markers and may reduce the risk of osteoporosis.

Introduction

We have previously shown in vitro and in vivo that lycopene from tomato is associated with a protective effect on bone, but lycopene intervention studies have not been reported. Our aim was to carry out a randomized controlled intervention study to determine whether lycopene would act as an antioxidant to decrease oxidative stress parameters, resulting in decreased bone turnover markers, thus reducing the risk of osteoporosis in postmenopausal women.

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Acknowledgments

Funding is shared by the Canadian Institutes of Health Research (CIHR) and the Research and Development Departments of Genuine Health Inc., the H.J. Heinz Co, Millenium Biologix Inc. (Canada), Kagome Co. (Japan), and LycoRed, Ltd. Israel. We especially thank Dr. Z. Liu for processing the extracted carotenoid samples and determining the carotenoid content using the HPLC software. We gratefully acknowledge: Amy Strauss, Dr. C Derzko, and Karl BruckMueller, for allowing us access to their list of patients who had signed consent forms indicating interest in studies related to bone health. A special thank you to the following students for their assistance with participant recruitment: A. Dias, T. Huang, M. Maksimowski, M. Simms, and K. Zarudny, and S. Ho for assistance with the dietary analysis.

U.S. Department of Agriculture ARS (2009) USDA National Nutrient Database for Standard Reference, Release 21. Nutrient Lists. Carotenoid (µg) Content of Selected Foods per Common Measure, sorted by nutrient content. In United States Department of Agriculture.Google Scholar