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The symposium will provide a broad view of the state-of-the-art of Physiology and Pathophysiology in 2018. World leaders in the field, with no less than 13 Members of Academia Europaea including 4 Fellows of the Royal Society and 3 Members of the German National Academy of Sciences Leopoldina, will present recent discoveries within wide perspectives. Reflecting the broad interests of Ole Petersen there will be a major focus on intra- and inter-cellular signalling events in a number of different systems, including the gastro-intestinal tract and the brain.