After a five season run on I Love Lucy, Lucille Ball and Vivian Vance return to the small screen in The Lucy Show. This time they play a pair of widows, Lucy Carmichael and Vivian Bagley, living together as best friends with their children Chris snd Jerry Carmichael and Jerry Bagley in Danfield, N.Y. In the first Lucy lived on a trust fund left behind by her late husband, watched over by a tightfisted banker, Mr. Barnsdahl (Charles Lane). The second season finds a cast change with Mr. Theodore J. Mooney taking over as the hotheaded banker. Vivian Vance quit the series after season three causing yet another big format change. Season four finds Lucy's daughter headed off to college and son Jerry shipped off to a military academy, leaving Lucy alone on the show. So, Lucy heads off to a Los Angeles apartment, and for reasons unknown, Mr. Mooney transfers to a bank there also, to remain as her comedic foil. This season also saw a number of guests appearing weekly to play off of. Lucy would also work for Mr. Mooney at the bank during this season. May Jane Croft was also brought in as Lucy's best friend this season.

At the end of the season, Lucille Ball would sell off her remaining interest in the Desilu studios which produced the series. She canceled The Lucy Show, reformatted it and returned as Here's Lucy in 1968.