Unholy 2-handed PvE Mechanics

The point in Desecration can go in either Unholy Command or Resilient Infection--none of the three will affect your raw damage. The remaining 2 points can go wherever you want to put them with no noticeable effect on your damage output.

Dps is done in Unholy Presence.

Your ghoul will be the ability contributing the highest percent of your toatal damage, followed by Scourge Strike and then Death Coil.

Single Target PriorityDiseases > Dark Transformation > Death and Decay/Scourge Strike if both Unholy and/or all Death runes are up > Festering Strike if both pairs of Blood and Frost runes are up > Death Coil if Sudden Doom, 100 RP, will overcap RP with anything else or if Runic Corruption isn't up > Death and Decay/Scourge Strike >Festering Strike > Death Coil > Horn of Winter

Death and Decay is used in the single target rotation of both 2h and DW builds due to its hidden 11th (16th when glyphed) tick, as a replacement for Scourge Strike whenever posible.

Keeping up diseases is the most important thing. While they only last 33 seconds and Outbreak has an unreducable 60 second cooldown, Festering Strike will bridge the gap, making it so you never have to resort to Icy Touch or Plague Strike in regular play.

Then comes Dark Transformation, whose uptime needs to be maximized for optimal dps. Dark Transformation boosts your ghoul's damage 100% overall with a 20% Claw specific boost, on top of Claw then cleaving. The second you can Dark Transformation, you do--no exceptions unless your ghouls is uanble to attack the boss at the time.

You never want to waste runes, which is why Death and Decay/Scourge Strike and Festering Strike when both of their respective rune costs are up comes next.

Just as you don't want to waste runes, you don't want to waste potential Sudden Doom procs (by having it just override a yet-to-be-used current one), runic power, or potential Runic Corruption (by having back-to-back procs), which is why you prioritize Death Coil here.

After all the above is factored away you simply Death and Decay, Scourge Strike, Festering Strike, and Death Coil. The order isn't particulary important unless the mob is nearly dead--in which case you go in that order. If you can, you want to try and avoid back-to-back Death Coils, due to the potential loss of Runic Corruption uptime but soemtimes it can be helpful if it will let you get Dark Transformation up significantly sooner.

It's worth nothing that when an npc is constantly healing itself, Necrotic Strike replaces Death and Decay/Scourge Strike in your rotation.

Multiple Target

Isn't much different.

Diseases > Dark Transformation > Death and Decay > Scourge Strike if both unholy and/or all Death runes are up > Blood Boil and Icy Touch if both pairs of blood and frost runes are up > Death Coil if Sudden Doom, 100 RP, will overcap RP with anything else or if Runic Corruption isn't up > Scourge Strike > Blood Boil and Icy Touch > Death Coil > Horn of Winter

Differences: when you apply diseases, spread them with Pestilence.Blood Boil use for Unholy always results in a leftover frost rune which one has no choice but to use for Icy Touch. The two, in combination, replace Festering Strike in your rotation.

As long as there are three or more mobs present, Blood Boil and Icy Touch is woth using in place of Festering Strike.

When AoEing, ALWAYS switch to frost presence.

Glyphs

PrimeGlyph of the GhoulGlyph of Scourge StrikeGlyph of Death and Decay (for AoE/DW)Glyph of Dark DeathGlyph of Icy Touch (for AoE)