Interstitial Cystitis and MCP-1-induced increases in histamine release; role of PEA

Chronic Bladder Syndrome can be treated with PEA 1200 – 2400 mg/day; this brings the mast cells to rest.

Interstitial Cystitis or chronic bladder syndrome (or bladder pain syndrome) is associated with a number of symptomatic sequelae that are poorly understood on a mechanistic level. The current study provides evidence suggesting that MCP-1-induced increases in histamine release are associated with CCR2 surface proteins on Mast Cells and are involved in the development and progression of IC/BPS.