Received a systemic investigational cGVHD treatment within 28 days of study entry. Prior treatment is allowed with a washout of at least 5 half-lives or 28 days. (Note: Corticosteroids, calcineurin inhibitors, sirolimus, MMF, methotrexate and ECP are acceptable and subjects must have been on a stable dose / regimen of these for at least 2 weeks prior to screening).

Histological relapse of the underlying cancer or post-transplant lymphoproliferative disease at the time of screening.

Current treatment with ibrutinib. Prior treatment with ibrutinib is allowed with a washout of at least 28 days prior to randomization.

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