Designed ankyrin repeat proteins (DARPins) can recognize targets with specificities and affinities that equal or surpass those of antibodies, but because of their robustness and extreme stability, they allow amultitude of more advanced formats and applications. In research, they have been established as intracellular, real-time sensors of protein conformations and as crystallization chaperones. For future therapies, DARPins have been developed by advanced, structure-based protein engineering to selectively induce apoptosis in tumors by uncoupling surface receptors from their signaling cascades. They have also been used successfully for retargeting viruses. In ongoing clinical trials, DARPins have shown good safety and efficacy in macular degeneration diseases.These developments all ultimately exploit the high stability, solubility, and aggregation resistance of these molecules, permitting a wide range of conjugates and fusions to be produced and purified.

IBCP Confernce Room level -1

Lundi
24 / 10 / 2016
11h00

"Transmitting an epigenetic “memory of germline” across generations and through development"

LyonSysBio is the yearly international conference organized by BioSyL (http://lyonsysbio2015.sciencesconf.org/?lang=en), the Systems Biology Alliance of Lyon.
Its goal is to promote exchanges between scientists from different fields (biology, mathematics, computer sciences, physics, social sciences…) interested in the analysis of the wealth of data generated by modern biology, as well as the construction of the necessary modeling tools to gain system level thoughtful insights.
In 2015, the conference will be held from the 18th to the 20th of November in Lyon. It will be dedicated to discussions around the 4 following themes: systems immunology, cell differentiation, a systems view on genotype-phenotype relationship and microbiological systems biology. Keynote lectures will be delivered by the following speakers:
Gregoire Altan-Bonnet (MSK cancer center, New-York)
Becca Asquith (Imperial College, London)
Chris Bakal (Institute of cancer research, London)
Sckjoon Jun (University of California, San Diego)
James Locke (University of Cambridge)
John Marioni (European Bioinformatics Institute, Cambridge)
Carsten Peterson (Computational Biology & Biological Physics, Lund University, Sweden)
Andreas Wagner (IEU, University of Zurich)