Using animation, Drs. Kartik Chandran and Jonathan Lai explain how they worked with a team of scientists to develop a new therapeutic strategy to target a hidden Achilles’ heel shared by all known types of Ebola virus. Two antibodies developed with this strategy blocked the invasion of human cells by all five ebolaviruses, as described in their paper published online in the journal Science on September 8, 2016. The team included scientists from Einstein, U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID), Integrated Biotherapeutics, Vanderbilt University Medical Center, and The Scripps Research Institute.This research was supported by the National Institute of Allergy and Infectious Diseases (NIAID) and the Defense Threat Reduction Agency (DTRA). See accompanying release (September 08, 2016)