SUPERKILLER-E

1.1. "Superkiller-E" (20% emulsion concentrate) is pyrethroid insectoacaricide, the active ingredient of which is cypermethrin - a-cyano-3-phenoxybenzyl-cis trans 2,2-dimethyl-3-(2,2-dichlorovinyl) cyclopropanecarboxylate (empirical formula: C22H19O3NCl2). The drug by its appearance is oily liquid with white to yellow-brownish color and weak specific smell.

1.2. The drug is pre-packed in polymer bottles, glass bottles by 100-1000 ml or in plastic canisters by 5-20 liters or in drums by 50-200 liters.

1.3. The drug should be stored with caution (See list B) in original packing inside warehouses separately from food and feed products away from open flame or other heating devices at room temperature. Shelf life of the drug is 2 years from date of manufacture under specified storage conditions.

2. PHARMACOLOGICAL PROPERTIES2.1 Effect of the drug is that its components inter-act with nerve membranes of insects by blocking ion channels, thereby preventing normal conduction of nerve impulses. Fat emulsion preparation contributes to rapid penetration of the active ingredient, which leads to the death of parasites.

2.2 Cypermethrin belongs to moderately toxic compounds for warm-blooded animals and in recommended doses does not cause intoxication if applied topically.

2.3 The drug is stable during storage, it is well emulsified with water to form emulsion with light milky color. The drug is active against eggs, larvae and adults of pasture and itching scabies, mites, lice, fleas, flies and mosquitoes.

3.DRUG USAGE PROCEDURE3.1 Animals are treated by spraying with aqueous solution (working emulsion) of "Superkiller-E" drug, for which various spraying disinfection facilities are used such as DUK, VDM, ODN and other mechanisms ensuring fluid pressure 2.5-3 atmosphere as well as stationary shower baths. During treatment of animals the temperature of the working emulsion should be within 15-25°C and the ambient temperature should not be below 10°C.

3.2 To combat pasture mites of cattle, horses, camels, sheep, goats and pigs a working emulsion is prepared based on 15 ml Superkiller-E drug with 18 liters of water. Animals are sprayed with emulsion until full wetting of the skin and hair. Repeated treatment of animals shall be carried out with 3 weeks interval before the end of the ticks attack season.

3.3 Cattle, camels and pigs are sprayed with working emulsion against scabies based on 75 ml of the drug diluted with 400 liters of water.

3.4 For prevention of scabies and in case of disease suspect sheep and goats are sprayed or bathed within 30 seconds to 1 minute with a working emulsion based on 75 ml of the drug per 830 liters of water. Bath is complemented with a working emulsion based on 75 ml drug per 622 liters of water. In severe cases of scabies affection the animals are sprayed or bathed in the working emulsion prepared on the basis of 75 ml drug per 500 liters of water, submerging the whole animal body into working emulsion within 30 seconds to 1 minute. In this case, the bath is additionally filled with a working emulsion based on 75 ml of the drug per 375 liters of water. If necessary, repeat the treatment after 10 days.

3.5 For elimination of flies 50 ml of the drug is diluted in 10 liters of water and in order to kill mosquitoes 50 ml of the drug is diluted in 20 liters of water and selectively spray areas they are clustered.

3.6 To kill ticks in livestock facilities it is necessary to treat such areas with working emulsion based on 50 ml of the drug per 10 liters of water. The area is sprayed based on 200 ml of the working emulsion per 1m2 of the surface to be treated. In 2,5-3 hours after treatment deactivation of the feed and water facilities shall be carried out by 3% solution of soda ash. Animals shall be placed into pre-treated facilities not earlier than 3-4 hours after completed desacarisation. During desacarisation of facilities lice, fleas, flies, mosquitoes and cockroaches, spiders and other insects are killed besides mites.

3.7 In cases of animal poisoning (depression, slobbering, frequent urination and symptoms of nervous disorders) the following antidotes should be administered subcutaneously: 1% atropine in the dose 1 ml per 100 kg body weight. If symptoms of intoxication do not disappear atropine shall be administered additionally at the same dose.

3.8 Slaughter of animals for meat shall be permitted after 10 days, use of milk for nutritional purposes shall be allowed 2 days after treatment. Milk and meat animals kept inside facilities treated with working emulsion shall be used for food purposes without limitations.

4. INDIVIDUAL PREVENTION MEASURES4.1 All operations with the drug shall be made in protective clothing rubber gloves and boots. It is strongly recommended to wear box respirators type "A" or breathing apparatus type F-62M, Astra-2, Lepestok-5, Lepestok-40 and Lepestok-200.

4.2 It is prohibited to smoke, drink, and eat during operations with the product.

4.3 At the end of operations you should wash your hands with warm water and soap and rinse your mouth and nose. Released container you should burn or bury.

4.4 If poisoning signs are discovered at workers exposed to drug effect (dizziness, nausea, increased salivation, lacrimation) it is recommended to stop operations, move the patient outside, remove protective clothes and equipment, wash hands and face with soap and water and seek for medical care. In case of contact with eyes it should be flushed with water or 2% solution of baking soda. In case of the eyes mucous membranes irritation it is recommended to drop 30% sulfacetamide or 2% procaine in case of pain. Specific antidotes: atropine sulfate, diaethyximum, 2-PAM.

4.5 The drug is toxic to fish, bees and other field insects.

5. CLAIMS PROCEDURE5.1 In case of complications at treated animals or inconsistency of the drug with requirements of this instruction, its use should be discontinued and reported to the Uzbek State Scientific and Veterinary Drugs Control Laboratory at: 700178, Tashkent, No.1a, A. Yunusov Street. Tel. / Fax: 118-96-74, 29-30-47. E-mail: uzgnkl@tkt.uz. Simultaneously unpacked drug package should be sent to the laboratory address with the drug including detailed description of the nature of complications.