Contents

When Francine first came to Springfield Elementary School, she was a loner. In an effort to be friendly, Lisa went up to talk to her, but Francine punched in the face. Later, Francine bit Lisa's Malibu Stacy doll's head off and then shoved her in her locker with Milhouse and Ralph. Francine continued bullying Lisa and the other children.

Lisa soon began to notice that Francine was only picking on the more unpopular children and leaving the other kids, such as Bart, alone. Through various observations and experiments, Lisa eventually determined the reason why bullies only targeted the nerdy children.

With permission from Francine's parents, Lisa presented her findings to the scientific community at the "12th Annual Big Science Thing". She proved that all nerds emit a pheromone, dubbed "poindextrose". She had also created a solution that masked this pheromone, making it undetectable to Francine. This calmed Francine down for a little while, but when Lisa ran out of the solution, Francine went on a rampage attacking all the scientists.[1]