PharmPK Discussion - Pharmacodynamic study of orlistat

On 6 Sep 2007 at 09:37:31, mohammed muhiyideen (mmuhiyideen.-a-.yahoo.com) sent the message

Dear freinds,we would like to do a pharmacodynamic comparision study of ourformulation with orlistat.for that i would like to know the fecal sample collection procedureand fecal fat determination method.i would like to know how muchfaeces should be collected and how often? already available oldvander kamer method of determination is too complicated, timeconsuming and involves usage of toxic solvents? so do any one of youknow any other simple method? is it possible using HPLC or LC-MS/MS?please do the needful.with thanks,MuhiyideenSenior-CRAQuest Life SciencesChennai.