The Gridiron Power Index (GPI), the index ranking for the NCAA Division I FCS and a top indicator of at-large playoff selection released its index after the action of Week 12 of the 2010 season.

The top four of the GPI were awarded seeds in the FCS playoffs – Delaware and William and Mary of the Colonial Athletic Association, Appalachian State of the Southern Conference, and Eastern Washington of the Big Sky Conference, though not in the exact same order that they appear in the GPI. Stephen F. Austin (No. 5) did not get a seed in the playoffs, but do host the defending national champions Villanova (No. 7) in an intriguing second-round matchup.