This bugreport has been closed because it does not contain enough
information for developers to be able to fix the issue.
The developers have asked for more information in the comments.
If the issue still occurs with the latest MyPaint version, please
file a new bug that includes as much of the requested information
as possible.

How much RAM do you have, and how big is that image approximately?
If you have saved it before, please rename the .ORA file to .ZIP, extract it, and tell me how big all the files inside the data/ directory are, and the content of stack.xml.

As a workaround, try closing other applications, and try saving to PNG instead of ORA. As a last resort, use the Save method of MyPaint version 0.1, that is, take a screenshot...

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