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Results from the study showed that the use of intravenous PRT4445 in 420 mg dose resulted in more than 95% reversal of the anticoagulant activity of Eliquis in two minutes. Eliquis’ anticoagulant activity decreased by 80% when the 210 mg dosage of PRT4445 was administered. The candidate was found to be generally safe.

We remind investors that in Nov 2012, Portola entered into an agreement with Bristol-Myers Squibb and Pfizer to evaluate PRT4445 in combination with Eliquis.

Portola is conducting a phase II study evaluating PRT4445 with another Factor Xa inhibitor, Xarelto. The study intends to evaluate the efficacy and safety of PRT4445 in combination with Xarelto across multiple dosages. The study aims to determine the dose of PRT4445 that will be able to reverse the anticoagulant activity of Xarelto in case of an uncontrolled bleeding or other emergency situations. The study is expected to be completed by year end.

We believe PRT4445 has significant revenue potential. Portola retains worldwide development and commercialization rights to PRT4445.

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