GenAge entry for FGF21 (Homo sapiens)

Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism

Gene name (HAGRID: 293)

HGNC symbol

FGF21

Aliases

Common name

fibroblast growth factor 21

Potential relevance to the human ageing process

Main reason for selection

Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism

Description

FGF21 is a pro-longevity hormone released by the liver that regulates glucose uptake in adipocytes. Transgenic overexpression of Fgf21 in hepatocytes increases average and maximum lifespan by 36% and 16%, respectively [3252]. Studies suggest that methionine restriction can reverse the negative effects of aging on body mass, adiposity, and insulin resistance through an FGF21 mechanism [3602]. Given these results and its role in metabolism, FGF21 may play a role in metabolic aspects of ageing. Additionally, FGF21 expression in the thymus declines with age. FGF21 overexpression in mice protects against thymic involution, increases perithymic brown adipose tissue and elevates thymic T-cell export. Loss of FGF21 in middle aged mice accelerates thymic aging. Thus, FGF21 may integrate the metabolic and immune systems [4359]. In humans, FGF21 has been associated with Type 2 diabetes.