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Cordarone I.V. infusions exceeding 2 hours must be administered in glass or polyolefin bottles containing D5W. Use of evacuated glass containers for admixing Cordarone I.V. is not recommended as incompatibility with a buffer in the container may cause precipitation. Amiodarone: I.V. DOSE. Dosing. The maximum cumulative dose in a 24 hour period should not exceed grams. Within the VT/VF pulseless arrest algorithm, the dosing is as follows: mg IV/IO push → (if no conversion) mg IV/IO push → (after conversion) Infusion #1 mg IV over 6 hours (1mg/min) → Infusion #2 mg IV over 18 hours.