Obesity and Type 2 Diabetes: Adipose Tissue Biology

David Sánchez-Infantes

David Sánchez-Infantes is a Miguel Servet Investigator Funded by the Instituto Carlos III (National Institute of Health of Spain). He is an emerging principal investigator and his team focusses on the study of obesity and type 2 diabetes. They search for molecules secreted by white and brown adipose tissue involved in the inflammatory state that occurs during the obesity. They also evaluate the capability of these molecules to inhibit/activate the brown adipose tissue and to modulate the properties of subcutaneous white adipose tissue, which is replaced by thermogenic beige adipose tissue (browning) in obesity. The goal of this group is to decipher why the excess of fat is inhibiting the normal activation and function of brown adipose tissue and browning, and to search for novel pharmacological approaches to treat obesity and related diseases.

Research lines

Novel cytokines involved in the inhibition/activation of brown adipose tissue function and browning

We search for molecules secreted by white and/or brown adipose tissue involved in the inflammatory state that occurs during obesity. We also evaluate the capability of these molecules to inhibit/activate brown adipose tissue, and to modulate the properties of subcutaneous white adipose tissue, which is replaced by thermogenic beige adipose tissue (browning) in obesity. The goal of this group is to decipher why the excess of fat inhibits the normal activation and function of brown adipose tissue and browning, and to search for novel pharmacological approaches to treat obesity and related diseases.