Gainesvillecity, seat (1853) of Alachua county, north-central Florida, U.S., about 70 miles (115 km) southwest of Jacksonville. The Spanish explorer Hernando de Soto marched through the area in 1539, and settlement eventually developed around a trading post known as Hog Town (established 1830). In 1853 the city was laid out as the county seat and named for General Edmund Pendleton Gaines, a commander during the War of 1812. Gainesville was the site of some minor battles (1864) of the American Civil War and was temporarily occupied by Union forces. After the war, citrus and cotton growing and phosphate mining became important in the area, but these activities had ceased by the end of World War I.

The University of Florida (1905) has played a major role in the city’s growth, and it remains the primary factor in the economy. Tourism and services (notably health care) are also important. The area still has some agriculture, including corn (maize), tobacco, and peanuts (groundnuts). Santa Fe Community College was opened there in 1966. Gainesville’s cultural institutions include a symphony orchestra, ballet company, and other music, theatre, and dance ensembles. The Florida Museum of Natural History and the Samuel P. Harn Museum of Art are on the university campus. The home of author Marjorie Kinnan Rawlings is preserved as a state historic site about 12 miles (20 km) southeast of the city. Parks in the area include Kanapaha Botanical Gardens, Devil’s Millhopper State Geological Site, Paynes Prairie State Preserve, and San Felasco Hammock State Preserve. Ocala National Forest is about 25 miles (40 km) southeast. Nearby is Newnans Lake. Inc. 1869. Pop. (19902000) city95,84,770447; Gainesville MSAMetro Area, 181232,596; (2000) city, 95,447392;