In this EMCREG-International Monograph, you will find a variety of cardiovascular articles which will hopefully be helpful to you in your practice of Emergency Medicine and Acute Care Medicine. These manuscripts are based on the 2015 EMCREG-International Satellite Symposium which was held on October 25, 2015, during the 2015 ACEP Scientific Assembly in Boston, Massachusetts. The symposium and this Monograph entitled Optimal Therapy for Acute Coronary Syndromes: Using Guideline-Based Treatments in the Emergency Setting explore multiple Acute Coronary Syndrome (ACS) topics which are extremely important to emergency physicians, hospitalists, and other acute care providers such as physician assistants and nurse practitioners as they care for these often critically-ill patients.