Exploring the CRISPR-Cas Defense System Kit (with perishables)

Item # 211772PNewOnline Only

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Intermediate - Easy to perform; requires some basic training in microbiology.
Students conduct experiments and analyze data over the course of this 5-day lab to understand the relationship between a phage called Andhra and its staphylococcus host. Their goal is to answer the driving question, How can we use evidence to model phage-host interactions and therefore explain the impact of a CRISPR-Cas system on bacterial survival?

Overview

Intermediate - Easy to perform; requires some basic training in microbiology.Bring new gene-editing technology into your classroom!
Your students walk in the footsteps of the scientists that first discovered this exciting gene-editing technology. Originally discovered as an integral part of the immune system of bacteria, you and your class explore the CRISPR-Cas system and its role in defending the host bacteria from viral bacteriophages. Bacteriophages outnumber bacteria 10:1 and have evolved an intricate immune system to combat invading phages. One such system, the CRISPR-Cas, uses small pieces of RNA to detect phages with matching DNA sequences, and destroys them.

Over the course of this 5-day lab, students conduct experiments and analyze data to understand the relationship between a phage called Andhra and its staphylococcus host and answer the driving question, How can we use evidence to model phage-host interactions and therefore explain the impact of a CRISPR-Cas system on bacterial survival? Note:Kit includes perishable materials. Please order 2 weeks prior to the requested delivery date. Perishables are only shipped on Mondays, Tuesdays, and Wednesdays. Plan to use the perishable materials within 1 week of receiving them.