Departments

Research Interests

Activation of T lymphocytes by recognition of a peptide/MCH at the surface of an antigen presenting cell (APC) requires the formation of a tight contact between the two cells, during which T cells undergo dramatic morphological changes. Maintenance of a stabilised interaction is correlated with full T cell activation. One of the earliest biochemical signals observed after T cell contacted an APC is the generation of PI(3,4,5)P3, products of the PI3-kinase (PI3K) activity. In many cell systems, PI3K is known to contribute to several aspects of cell polarisation and migration.

The purpose of my work is to understand why PI3K-deficient T cells are defective in forming conjugates with antigen presenting cells and how this impacts on T cell function in PI3K deficient mice.

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