Fig. 6

Core-genome tree depicting species groups defined in Streptomycetaceae with our methodology. A UPGMA tree was constructed using the average of 157 matrices containing the pairwise patristic distances derived from each core-gene tree. Exclusive groups were defined according to the same matrix of average patristic distances for the 701 genomes. We then delineated as species the largest exclusive groups whose members met the joint ANI/AF criterion with a single-linkage approach. Singleton species are represented by blue leaves, whereas species with multiple genomes appear as a group of black leaves subtended by a brown edge