Special Instructions

Method Name

Reporting Name

MAPT Gene, Sequencing Analysis

Specimen Type

Varies

Shipping Instructions

Specimen preferred to arrive within 96 hours of draw.

Specimen Required

Patient Preparation: A previous bone marrow transplant
from an allogenic donor will interfere with testing. Call
800-533-1710 for instructions for testing patients who have
received a bone marrow transplant.

Specimen Type: Whole
blood

Container/Tube:

Preferred: Lavender
top (EDTA) or yellow top (ACD)

Acceptable: Any
anticoagulant

Specimen Volume: 3 mL

Collection Instructions:

1. Invert several times to mix blood.

2. Send specimen in original tube.

Specimen Minimum Volume

1 mL

Specimen Stability Information

Specimen Type

Temperature

Time

Varies

Ambient (preferred)

Frozen

Refrigerated

Reject Due To

No specimen should be rejected.

Reference Values

An interpretive report will be provided.

Interpretation

All detected alterations are evaluated according to American
College of Medical Genetics recommendations.(1) Variants are
classified based on known, predicted, or possible pathogenicity and
reported with interpretive comments detailing their potential or
known significance.

All variants will be reported in reference to transcript
NM_001123066 (build GRCh37 (hg19)).

Day(s) and Time(s) Performed

Performed weekly; Varies

Analytic Time

14 days

Specimen Retention Time

Whole Blood: 2 weeks (if available) Extracted DNA: 3 months

Test Classification

This test was developed and its performance characteristics
determined by Mayo Clinic in a manner consistent with CLIA
requirements. This test has not been cleared or approved by the
U.S. Food and Drug Administration.

Forms

1. New York Clients-Informed consent is required. Please
document on the request form or electronic order that a copy is on
file. An Informed Consent for Genetic Testing (T576) is
available in Special Instructions.