高血压时肾上腺皮质球状带及醛固酮分泌的变化Changes of the Zona Glomerulosa of the Adrenal Cortex and the Serum Aldosterone Level in Hypertension

用大鼠分三组进行实验:(1)主动脉狭窄组;(2)巯甲丙脯酸—主动脉狭窄组;(3)正常对照组。术后4周检查,颈动脉平均血压:(1)明显升高,(2)亦升高。血浆肾素、血管紧张素及醛固酮水平:(1)均有升高;(2)肾素升高,血管紧张素Ⅱ及醛固酮降低。肾上腺重量:(1)明显增加;肾上腺皮质球状带细胞体视学参数多数显示(1)比(3)增加,(2)则减少。上述结果表明肾素—血管紧张素—醛固酮系统在腹主动脉狭窄性高血压形成中起作用。Wistar rats were divided into 3 groups. (1) Rats with coarctation of the abdominal aorta (n=25); (2) coarcted rats treated with captoril, an inhibitor of angiotensin II converting enzyme (3mg/kg B W, bid. by gastric instilation) (n=26), (3) normal controls (n=25). 4 weeks latter, the rats were studied. The carotid blood pressure in group 1 and group 2 were markedly elevated as compared to the normal controls (20.5±0.3, l9.1±0.4, 16.1.±3 kPa respectively, p<0.01). The serum renin, angiotensin II and aldosterone in Group 1 showed a tendency to elevate while in Group 2, the renin activity increased, the angiotensin II and aldosterone levels decreased, The weight of the adrenal gand increased markedly in Group 1(26.82±7.99 mg/100g B W), and less markedly in Group 2 (21.13±6.07) as compared to the normal controls (18.77±5.65. P<0.05). Morphometric study of the zona glomerulosa showed increased cell density per volume in Group 1 and decreased in Group 2. The results suggest that the renin-angiotensin-aldosterone system do play an important role in coarctation hypertension, and perhaps in other forms of hypertension.