Use at an assay dependent concentration. ab170191-Mouse monoclonal IgG2a, is suitable for use as an isotype control with this antibody.

IHC-Fr

Use at an assay dependent concentration.

靶标

相关性E7 protein has both transforming and trans-activating activities. Disrupts the function of host retinoblastoma protein RB1/pRb, which is a key regulator of the cell cycle. Induces the disassembly of the E2F1 transcription factors from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. Inactivation of the ability of RB1 to arrest the cell cycle is critical for cellular transformation, uncontrolled cellular growth and proliferation induced by viral infection. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. Interferes with histone deacetylation mediated by HDAC1 and HDAC2, leading to activation of transcription

Thank you for contacting Abcam. I have contacted the lab about ab20191, which is a Human Papillomavirus 16 (E7) antibody [TVG701Y] and can be used in flow cytometry and western blot. However the lab has told me that we do not know what the immunogen ...

Thank you for your enquiry.
I am sorry to hear that you are experiencing difficulties with this product ab20191 in immunohistochemistry. Often it is possible to make suggestions that help resolve problems. We will happily offer technical support but...