Background:
Breast cancer is the most frequent cancer in women and consists of a heterogeneous collection of diseases with distinct histopathological, genetic and epigenetic characteristics. In this study, we aimed to ...

Background: TP53 mutations have been associated with resistance to anthracyclines but not to taxanes in breast cancer
patients. The MDM2 promoter single nucleotide polymorphism (SNP) T309G increases MDM2 activity and may ...

Assessments of diseases are usually performed by a combination of clinical
symptoms, signs and objective measurements. Biochemical markers of inflammation
are important in evaluation of treatment of acute and chronic ...

Background:
Complex traits, which are under the influence of multiple and possibly interacting genes, have become a subject of new statistical methodological research. One of the greatest challenges facing human geneticists ...

Background: Chemoresistance is the main obstacle to cure in most malignant diseases. Anthracyclines are among the main
drugs used for breast cancer therapy and in many other malignant conditions. Single parameter analysis ...