Nationality: United StatesExecutive summary: Karen Walker on Will & Grace

Mullally's father was a longtime bit-player in dozens of movies, rarely receiving on-screen credit. Her mother was a model, and young Megan grew up in Oklahoma City, where she was a singer of some local renown, peaking as soloist with Ballet Oklahoma, the local dance troupe. Bolstered by good reviews for her performances in a few college musicals, she dropped out of school in 1985 to pursue an acting career. She was able to earn a living as a stage actress in Chicago, and in the mid-1990s she starred in two Broadway revivals, Grease with Rosie O'Donnell, and How to Succeed in Business Without Really Trying with Matthew Broderick. She also played a hooker in Risky Business.

Will & Grace was Mullally's fourth prime time series. Earlier, she had played Ellen Burstyn's daughter on the mid-'80s sitcom The Ellen Burstyn Show, and she was a regular on Michael Apted's little-seen My Life and Times, and on Rachel Gunn, R.N..

At the 2005 Emmy Awards, she sang the theme from Green Acres in duet with Donald Trump. Earlier that year at the Women in Film Awards, co-star Debra Messing and Mullally were introduced as the new Lucy and Ethel, and fondled each other's breasts on stage (and on live TV).

Following the demise of Will & Grace, Mullally hosted a daytime talk show, The Megan Mullally Show, which was quickly cancelled.