Are there any general guidelines for pulsing immune modulators?

A couple of times many years ago I experienced significant relief from OTC immune modulators, but in both cases the products stop working. That was before I ever heard about pulsing to avoid that sort of thing happening. Imunovir has a very specific and somewhat elaborate dosing schedule. I was wondering if there was something more general that could be applied, like four weeks on, two weeks off (the less time off, the better, obviously). Also, during the time off, would it be possible, or would it be counterproductive, to take a different immune modulator?

with immunovir i have seen protocols where the dose is varied every day and also alternated every week with weekends off. My thoughts were why even take the low doses because the immune system will only fire up on the higher doses now and lower doses will just contribute to tolerance of immunovir, so i dose immunovir on a mon/wed/fri schedule of 3 tabs twice a day so there is 4 days a week where i dont use it.

Much of the info on pusling came from a series of articles based on interviews with Dr Cheney by Carol Sieverling in around 2000 and i've never seen an update. It's possible that Dr Cheney has mentioned this in one of his pay-to-view newsletters.

This is what was written then (personally I've found that a looser system of pulsing works or even taking a small dose each day and then forgetting or running out every now and then. I can't afford the full dose at the moment)

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Week one, take 6 tablets a day, Monday through Friday, and none on the weekend. Week two, take 2 tablets a day, Monday through Friday, and none on the weekend. Repeat this cycle. But do not treat every month. Do two months on and then one month off of this "pulsing" dose. This medicine works best when you do not treat regularly. If you treat continuously at the same dose, it stops working. It is an immune modulator, and Dr. Cheney suspects all immuno-modulators are like this. If taken continuously they stop working. The dose must vary so the immune system never knows what to expect.

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It is an immune modulator, and Dr. Cheney suspects all immuno-modulators are like this. If taken continuously they stop working. The dose must vary so the immune system never knows what to expect.