Sean and Christian have relocated their practice from Miami to Los Angeles. Being new to the city they find themselves having to start from scratch business wise. What they thought would naturally fall into place turns out to require some foot work. So Christian and Sean hit the town and begin discovering a whole new world.

A patient inspires Sean to take his relationship with Kate in a new direction. Eden uses extreme methods to persuade Christian to perform surgery on a friend. Kimber reaches out to an former business associate when she and Matt fall on hard times.

Sean tries to regain his youth through his relationship with Eden. A violent and traumatic event causes Julia to question her relationship with Olivia. In an effort to better her life, Kimber makes a decision that devastates Matt.

As Julia's health worsens, Christian falls back into old habits. Sean hires Gina as the new receptionist at McNamara/Troy in order to get back at Christian. Dawn Budge returns to McNamara/Troy after another unfortunate incident which requires cosmetic surgery.

Eden looks to Sean for help after getting into business with Kimber and Ram. A group of wealthy socialites hire Christian for all of their cosmetic surgery needs. Sean discovers another side of Colleen.

Tragedy strikes the McNamara/Troy family after Julia learns what has caused her ill health. A visitor from Christian's past brings revealing news. Sean finds the price of fame to be more expensive than it's worth.

After surviving the attack by Colleen, Sean's physical and emotional well-being are still feeling the effects. Meanwhile, Christian receives some disturbing news after lending Liz some moral support with her breast cancer scare.

After being rejected by Kimber on account of his post-surgery scars and with his chemotherapy making him sick, Christian seeks support from Liz, which leads to a surprising sexual encounter between them. Sean discovers his new lover (Jaime Ray Newman) has a disturbing fetish, and further alienates Julia and Matt when they learn that he has been faking his need for a wheelchair. Raj has a life-altering sexual encounter with the wife (Beth Gargan) of McNamara/Troy's latest patient.

Aidan Stone, a down-on-his- luck writer who has written a biopic about Sean, wants to use it to relaunch his career. Christian is asked by Kimber to give a Botox injection to her daughter so she has a better chance at becoming a baby model. Sean and Christian have been asked by a yoga instructor to perform a procedure in which neither have ever done before.

A horribly disfigured man is worked on by Christian and Sean. Meanwhile, Sean hopes to strike up a relationship with the new anesthesiologist Teddy Rowe, and Christian goes for a check up with his oncologist.

As Christian and Liz make their wedding plans, he also looks for a new cancer treatment. Meanwhile, Ram Peters drops Kimber for a newer model, while Teddy informs Sean that someone close to her is gone, and Sean and Christian repair a couples neck wounds which look strikingly similar at McNamara/Troy.