Yasmin Le Bon took a brief hiatus from modeling in 1986 to recover from a miscarriage. Soon she returned to the business and in April 1987 was hired by GUESS? for a key advertising campaign. In the late 1980s She appeared on the cover of the first American and British issues of Elle. She has also been on the covers of Vogue, V, I.D., Cosmopolitan, Marie Claire, Harper's Bazaar and many others.

Le Bon eventually gave birth to a daughter, Amber Rose, in August 1989. She was back on the catwalks within weeks. In September 1991, Le Bon had her second daughter, Saffron Sahara, and then, in 1994, had her third, Talullah Pine. In the spring of 2001, Le Bon, a 36-year-old mother of three, modeled bikinis for Marks & Spencer. In 2003, she signed an exclusive deal with designer Matthew Williamson and his sponsor, Ariel Essential.