In 1997, my colleague, Omar Ali, and I described our oxidative theory of coronary heart disease and introduced the term oxidative coagulopathy for microclot and microplaque formation in the circulating blood.10 We conclusively demonstrated that coronary artery heart disease is, first and foremost, caused by oxygen-driven oxidative stresses in the circulating blood. We also marshalled extensive evidence to support our view that natural cholesterol, an antioxidant, cannot cause coronary artery disease.

Returning to the subject of oxygen and aging, the essential question is the same: Can coronary bypass operations and stents that do not work help people with heart disease live to be 115 years old?

Drugs for lowering blood levels of cholesterol bring the most money for drug companies. Predictably, doctors in university hospitals get the most grant money for writing cholesterol papers. So it is that at least every month one or more prestigious medical journals carry cholesterol papers extolling the virtues of cholesterol drugs. (How else would the doctors get the future grant dollars?) Amazingly, the current advice is that people should be taking cholesterol-lowering drugs even when the cholesterol level is within the so-called normal range. Such drugs have a clear risk of causing cancer, liver disease, fatigue, and other problems, but that does not seem to temper the infatuation with drugs.

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