The following information is NOT intended to endorse drugs or recommend therapy. While these reviews might be helpful, they are not a substitute for the expertise, skill, knowledge and judgement of healthcare practitioners in patient care.

Reviews for Acetaminophen/dichloralphenazone/isometheptene mucate

Sort by:

For Headache:"I was bedridden for 2 years for my debilitating migraine. I was prescribed Dilaudid by my neurologist. He had no idea how addictive the drug was and when he found out I was sent to rehab to get off of it. The hospital prescribed me the generic for Midrin. It gave me my life back. I'm devastated because this drug is no longer available. I experienced my first pain level 10 and was confined to bed. Being bedridden due to my migraine is not an option. Please put it back on the market."

For Headache:"This medication changed my life for the good. I have taken it as needed for over 25 years without any side effects. Knowing this medication is no longer available has adversely impacted the quality of my thought life. This medication worked every time. No more costly pain filled trips to the ER. No more missed work. Now, my life will never be the same. I am not alone as this medication has been a miracle to others as well. Now my medical bills and lost wages will sky rocket. These other medications are not safe and I won't take them. I just hope that somehow this medication can soon be available again. My life is not the same without it."

Midrin (acetaminophen / dichloralphenazone / isometheptene mucate) for Headache:"I have had migraines since 2008, I went through every kind of pill imaginable until my Neurologist prescribed Midrin-finally something that actually worked! Then after a couple years it was nowhere to be found and therefore I suffered horribly trying to get by with Naproxen which is basically useless. Last year I was able to get Midrin again-even though I have to pay $4 a pill for it-it's cheaper than a trip to the ER for the "really bad ones". Fast forward to couple a months ago, I went from 2 different Rite Aids to then 2 different Walgreens getting my Midrin filled is always a rigamarol. Today I called to see if my prescription was ready and they said Midrin and equivalents were discontinued! I am freaking out-this is the ONLY thing that works for my bad migraines. Please FDA figure out what you need to and get this stuff back on the shelves!"

Midrin (acetaminophen / dichloralphenazone / isometheptene mucate) for Headache:"I was born w migraines. So I tried many many many different migraine meds. Only mildrin relieved my pain. And I had no side effects. W the others meds my throat was so dry couldn’t swallow. And my heart had palpitations and I felt like a zombie. Please FDA put midrin back on the pharmacies. You have no idea that midrin has the least harmful side effects"

Midrin (acetaminophen / dichloralphenazone / isometheptene mucate) for Headache:"It was the best cheap drug for migraines. Nobody wants to make it now because it doesn’t make pharmaceuticals enough money. What is the FDA thinking? All those years, no deaths and I don’t know of any serious side effects. And it worked for many people. Even migraine headache clinic wrote scripts for it all the time. Because it worked.
Now FDA markets all kinds of drugs which cause serious side effects and death.
I understand the rules for FDA has changed and more stringent now. So new studies, new manufacturers and prices are jacked up.
And worst of all, we still get migraines with no Midrin"

Midrin (acetaminophen / dichloralphenazone / isometheptene mucate) for Headache:"I suffered many years with migraine headaches so severe that they would render me useless for anything for a day or two. Because of the headaches, I would worry and be anxious about when the next one would come. As a result, they became more frequent eventually occurring about once a week. I tried many pain-relieving drugs and doctors without success. Eventually, I found a doctor who suggested Midrin even though he didn't know if it would help. He prescribed a total of 6 pills over a 5-hour period to relieve pain. I found that it completely removed pain after 1 tablet. I also felt more relaxed (less anxious). The headaches became less frequent to the point that I might go for a year without a headache. Just having the Midrin with me helped tremendously."

Midrin (acetaminophen / dichloralphenazone / isometheptene mucate) for Headache:"I have suffered from terrible migraines for many many years. Tried many different things from my family doctor and nothing would take away my headaches. Finally my Dr sent me to a neurologist and she put me on midrin and it was a miracle ! I took my first midrin pill and Just like that, (snap), my headache goes away! Usually only need one to get rid of it, on rare occasion had to take another. It never failed me and I had zero side effects and did not ever feel high or impaired in any way whatsoever. And it is not addictive! And I agree with the other lady that commented on this medication, we need to start a petition or send letters or call the surgeon general or someone in the government to stop this insanity of not permitting this long time, proven safe and effective and non addictive medicine that has hardly any side affects (in most cases NO SIDE EFFECTS) tried and true for decades migraine. Lets get MEDICATION back in pharmacy's in America!"

Midrin (acetaminophen / dichloralphenazone / isometheptene mucate) for Headache:"I used to have bad migraines and I could ALWAYS count on Midrin to stop it in short time. In the 1980'S when I took it, it would give you a distinct celery taste in your mouth as you felt your headache melt away. I eventually quit getting headaches...until recently. I was surprised that my doctors were unfamiliar with
Midrin since it was so effective. But I was even more surprised to learn that Midrin in its original form, was discontinued. Why?? Anyway, tonight I bought a generic version, which was NOT covered by my insurance. No classic celery taste any more and it took a little longer, but my headache is 90% gone after 1 hour. Not as good as the original but still great med."

Midrin (acetaminophen / dichloralphenazone / isometheptene mucate) for Headache:"Midrin was the best migraine medication! As far as I know I cannot get it anywhere in the area that I live locally in Lake City Florida. I was reading this post to see if anyone had any ideas. I guess I will check on having it compounded at a pharmacy. I have tried Fioricet and fiorinal and they work but my doctor does not like to prescribe them because they have the potential for dependency. She has prescribed for me amerge, it is a triptan and it works but my insurance does not want to pay for it. I do have high blood pressure and sometimes it affects that. Sometimes I use toradol and that works, but it cannot be used regularly."

Epidrin (acetaminophen / dichloralphenazone / isometheptene mucate) for Headache:"Coping with photophobia and migraine with aura for over 20 years has been a disabling part of my life. I have been getting 40 injections every 10 weeks and this medication is the ONLY breakthrough medication that allows me to resume any daily activities during a migraine until my next course of treatment. Other medications have exacerbated my symptoms or added new side effects that make it intolerable. This has allowed me to live as normal a life as I can."

Midrin (acetaminophen / dichloralphenazone / isometheptene mucate) for Headache:"Midrin is the only medication that I have had success with to combat a migraine. I could take it at the onset of a migraine to stop the pain dead in it's tracks. I'm currently taking Sumatriptan (generic Imitrex) which makes me sleepy enough to sleep through the pain but doesn't always elevate the pain. I've been researching Midrin today to learn whether or not it will ever be available again for migraines but I'm not having much luck. Posting here to see if anyone knows the status and to ask other what meds they used if Imitrex didn't work for them."

Migrex (acetaminophen / dichloralphenazone / isometheptene mucate) for Headache:"I’ve taken one pill a day and it stopped headache in about an hour but headache didn’t return for 24 hours. I was afraid to take migrex because company didn’t require prescription. I think it has different ingredients depending on the country it is from. Also, it contains Tylenol (under the chemical name acetaminophen). I took the drug because I have severe pain almost 3/4 of the month and I had such a horrid headache I wouldn’t have cared if migrex killed me. What a surprise! I have imitrex and am suppose to use sumatriptan stat and migrex long term. Odd company didn’t require prescription??? That makes me nervous."

For Headache:"I have a history of migraines with aura (my mom has them too), and a few years ago my doctor prescribed me generic Midrin when I was having some of the most excruciating migraines of my life because of hormone fluctuations. I was very sceptical that it would do anything more than ibuprofen or excedrin ever had, but was blown away that it actually reduced 95% my symptoms when they struck! I didn't think anything could actually cover up the pain and nausea and sensitivity. I now keep a bottle of Midrin handy in my medicine cabinet for when I get those debilitating migraines that nothing else will touch. Thankfully I don't get them too often since Medicaid won't cover it and the cost is 180$... :("

Midrin (acetaminophen / dichloralphenazone / isometheptene mucate) for Headache:"Midrin was the most effective medication I've ever taken for migraine. I can not take triptans as they cause my blood pressure to rise dangerously. When it was discontinued I was given multi other drugs to use without success. Now I stick with over the counter and suffer when they are ineffective."

For Headache:"Loved Loved Loved this medication. It knocked my headaches out in 10 minutes and It also reduced the amount of times I got them. I was so sad when my doctor stopped proscribing them to me due to my insurance"

Midrin (acetaminophen / dichloralphenazone / isometheptene mucate) for Headache:"Like previous reviewers, I find the Midrin substitute hit-or-miss. Taking Midrin early or late in the headache seems not to matter; sometimes it works, sometimes it doesn't. I took Midrin in the early 80s, and it worked every time, and fast. (the effect was as if my head just floated away, but I could still function). With the Midrin substitutes, the headache just slowly subsides. Either the formula is different or I am, but it's not the product it used to be. Still, it's the only thing that comes close to working for me."

For Headache:"The only thing that works for the complex migraines w/ vertigo and gastroparesis that I get as a result from a vagal nerve injury.
Other migraine medications have caused heart complications, so this is it for me. It's terrifying whenever there's a shortage."

Midrin (acetaminophen / dichloralphenazone / isometheptene mucate) for Headache:"For me Midrin is very hit or miss, when I take it at onset of a bad headache, sometimes the headache just in time vanishes before it ever begins, then sometimes its as if I took a placebo, granted the drug has 0 side effects for me. Overall, it's worth having if you have back-up drugs for when it does not work. For those of you that like myself get a terrible trifecta of Migraine, Tension, and Cluster Headaches. You probably know like me that no meds really take the headache away completely once you have one."

Midrin (acetaminophen / dichloralphenazone / isometheptene mucate) for Headache:"I began having vascular migraines in the 70s and nothing worked until I was prescribed midrin. My rating is for the current midrin formula as it doesn't seem to work as well as it did back in the day when I was first prescribed it... back then it far surpassed 10! It is still an effective migraine drug with less side effects than some other drugs that I was prescribed when midrin was unavailable. It works quickly and, unless it is a really bad migraine, basically allows me to still be able to function once the headache subsides.
Currently, my Medicare drug plan doesn't cover it and it is expensive--- over $3.00 a capsule, unless you can find a coupon. Last time it was filled I had a coupon and paid $1.12 a capsule."

Midrin (acetaminophen / dichloralphenazone / isometheptene mucate) for Headache:"As of this review (Spring 2017) only one company makes it (Macoven Pharma.) It is the best migraine treatment for me whatever variation of name it is dispensed as: "Midrin" "Commonly known as Midrin" "Epidrin" "isometheptene-dichloralphenazone-acetaminophen" "Isometh/Dich/Apap 65-100-325." At onset of migraine I take 2 capsules Midrin and 20-30 minutes later the migraine just starts to disappear. Make me sleepy - that's the only downside and one I can manage. Usually first dose is enough, occasionally I take one more Midrin capsule an hour later. I went through years trying out various Rx's, shots, treatments with my doctor, but once we tried Midrin I got my life back. Difficult to find pharmacy to supply, but worth it!"

For Headache:"Midrin, Epidrin, isometheptene-dichloralphenazone-acetaminophen, Isometh/Dich/Apap 65-100-325, whatever variation of name it is dispensed as, it is the best migraine treatment for me. It must be administered early into the headache or it is much less effective. That's the only downside, and one I've managed to deal with successfully over many years now. I take 2 capsules at onset and one more tablet each hour after as needed (usually total of three capsules is enough!) Only side affect is it makes me sleepy. I went through two years trying out various Rx's, shots, treatments with my doctor, but once we tried Midrin I got my life back.The difficulty getting it lately has me jumping through hoops and the price skyrocketed, but it's worth it."

Midrin (acetaminophen / dichloralphenazone / isometheptene mucate) for Headache:"Midrin works very well on the onset. Stops the "gritty" pain and brings my headache/beginning migraine down to almost nothing. I do get a bit lightheaded and sometimes a bit amped, but its totally worth it. I used to take 2 on the onset and rarely had to follow up on the next hour or two. Now I only take 1 on the onset and I'm fine. When the pill winds down I feel tired so I when taking the pill I plan on resting later that day and not to over-exert. I have Chiari I."

Midrin (acetaminophen / dichloralphenazone / isometheptene mucate) for Headache:"I was having severe migraines for about 5 months. The doctor tried every medication available. I would only buy 4 because I didn't want to waste money on the whole prescription and it not work. Imitrex made me so sick!!! I had remember from the early 90's when I would get cluster headaches and the doctor put me on Midrin. Out of the blue, I asked the doctor to try this again. He didn't think it was available, but my pharmacy said they could compound it. Again I bought 4 pills, thinking I was wasting my money but desperate. Bam.... migraine stopped within 20 minutes of taking. Sometimes, it takes a second dose if I have a severe one. But, I feel it is under control now. I have fibromyalgia, the migraines are a sensory issue smells, sounds."