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Valter Longo must be one of the most interviewed guys in the latest coupla years.
I just listened to the stemtalk interview (Ken Ford is usually biased on the ketogenic diet, but he's been evidently able to overcome this bias), where new aspects on his proposals are underlined: IGF-1 and its sweet spot, local and general IGF-1. No coffe when fasting and when on his FMD.
One pretty interesting issue is that about the 'phantom carbon sources', nutrients which are utilized by the body but not recognized as nutrients. Fibers? Else?
I googled 'phantom carbon sources' but found no relevant results so far .
https://www.ihmc.us/stemtalk/episode-64-valter-longo-talks-about-the-fasting-mimicking-diet-and-the-keys-to-longevity/

Valter Longo's work has been discussed around here quite frequently as of late, particularly his work on the fasting mimicking diet. In typical Rich Roll fashion, he goes long form and tries to gain deep insight into Longo's understanding of nutrition, longevity, and health. Rich says that he considers it one of his most important conversations to date.

I'm sure this movie will be of interest to many CR members. I just watched it and thought it was an interesting film that included the pros/cons of fasting. The movie talks about many different forms of fasting (IF, TRF, multi-day water fasts, juice fasts, etc.). It includes appearances from many big names including Valter Longo, Alan Goldhammer, and many more. Before I muddy the waters and give my thoughts, I would be curious as to what others think. The cost to rent it is relatively inexpensive.
The movie can be viewed here:
http://fastingmovie.com/

Hi everyone,
Many people have been asking, both here and elsewhere, about the safety and efficacy of various time-restricted eating schemes.
This is of particular interest to me since, for reasons that are irrelevant to most here (an unusual constellation of health challenges), I have been finding conventional CR (=the same, low energy intake per day) unworkable.
Before I continue, I should emphasize that the best bet for health and longevity, based on the science we have (which is limited), is indeed conventional CR.
But for those who want to try time-restricted eating, I'm wondering about the relative merits of two approaches, and I'd appreciate feedback. I've been thinking this through mostly on my own, and find myself unable to reach a conclusion. Experimental evidence is so limited, I think it's more helpful to reflect a bit on mechanisms, or even evolution. (More helpful doesn't mean very helpful, though....)
Type 1: Longo/FMD.
The evidence for benefit in both lab animals and humans is limited, but is at least somewhat compelling. It seems unlikely that there's any antiaging benefit per se, beyond that which would have obtained with the same overall ("longish-period averaged") reduction in calories.
Type 2: "Inverted FMD".
If the Longo approach involves having non-CR signaling patterns (high mTOR, IGF1, insulin, etc.) be the norm, with a sudden several-day period of CR signaling patterns being the exception, "inverted FMD" would be CR, perhaps somewhat mild, as the norm, with a several-day, or week-long period of "feast" signaling. (Credit where credit is due: James Clement is the one who suggested this pattern of eating as possibly better than the Longo pattern.)
Type 1 vs. Type 2.
Type 2 seems to me to be more like the pattern of eating under which we evolved – scarcity as the norm, with the occasional feast when the tribe came upon a bunch of food – but that doesn't say much about its benefits, though it might suggest that the body would be more adapted to it.
Hm.... what we really need is more science on this. Does anyone here know Longo? I've emailed him a couple times and not gotten a response. A small trial comparing the two approaches could be helpful (though only slightly of course, since the main interest of many here is effect on mortality, for which we still don't have great biomarkers).
Brian

Hi all,
I have enjoyed consuming content on this forum. Thank you to all members who actively post. Please know that many lurk in the background and benefit from the exchange of knowledge.
I am about to embark on my first FMD using the Prolon box. I have previously completed water only fasts. I will compare FMD changes in biomarkers to those of other fasting interventions (water, self-hacked FMD, etc.)
I was planning to track the enclosed at onset and immediately post FMD, any suggestions on others?
IGF
FBS
Ketones
hs-CRP
ESR
Homocysteine
CBC
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Microbial load (uBiome)
Organic Acids Test (Great Plains, urine)