Watch for knockback. The fight takes place on a plateau and you don't want to get knocked off the plateau. You can take cover behind the various rocks that are scattered around. Also one side of the area has a cliff wall, so fight with your back to that wall so that you don't fall when you get knocked back. This won't keep you from dying, but it will keep you from getting knocked off.

Terramorphous the Invincible drops mediocre loot, often greens to purple, with one orange class mod dropping each time. Rarely drops the items Fire teeth of terramorphous, breath of terramorphous, hide of terramorphous or the blood of terramorphous.