News

To understand the impact of gestational diabetes on the foetus by investigating gene expression and DNA methylation to look for epigenetic perturbations that may lead to an unfavourable outcome in the offspring.

Postpartum Akt activation is detrimental for the peripartum heart as it lowers anti-oxidative defence and in combination with low STAT3 conditions, accelerate cardiac inflammation and fibrosis. PRL and its cleaved 16 kDa form are central for Akt-induced PPCM, as indicated by the protection from the disease by PRL blockade.