First ever human interventional study demonstrating aerobic exercise training-induced improvements in human cerebral haemodynamic function. This important information provides support for exercise as a prophylactic countermeasure against the neurological diseases associated with human ageing.

Human study that provides mechanistic insight into the control of cerebral blood flow (CBF) during acute exercise in the aged. Compared to young controls, aged participants exhibited a suppressed exercise-induced increase in CBF despite less hypocapnic-induced cerebral vasoconstriction.

Human study demonstrating that CBF is well-maintained during marked changes in perfusion pressure following postural changes. These mechanistic findings have implications for the aged who when syncopal during orthostatic stress are more at risk of falling.

Cross-sectional study that provides the first ever human evidence to suggest that regular aerobic-endurance exercise is associated with elevated cerebral perfusion across the human lifespan. This provides complementary mechanistic insight into why increased physical activity is neuroprotective and can prevent stroke and dementia.