2017年8月24日 星期四

Background

Evidence of vascular dysfunction in migraine is increasing. MicroRNAs (miRs) have emerged as important regulators of vascular endothelial functions. This exploratory study investigated whether circulating levels of miRs associated with endothelial function are altered in migraine patients.

Methods

Thirty patients with migraine (20–50 years old) without overt vascular risk factors and 30 sex- and age-matched healthy controls participated. The levels of four miRs that regulate endothelial function (miR-155, miR-126, miR-21, and Let-7g) were quantified and expressed in terms of fold changes (2-ΔΔct) relative to mean levels in the control group. Associations of miRs levels with headache features and syncope comorbidity were explored.