"Real Time" airs live at 10 p.m. Friday on HBO. It will repeat at 11:30 p.m. that night.

Silverman will be the mid-show interview. The top-of-the-show interview will be Pulitzer Prize-winning journalist Jose Antonio Vargas. He is an immigration activist who founded the group Define American, which he describes as "a campaign that seeks to elevate the immigration conversation."

The panel will be playwright/actress Anna Deavere Smith, CNN host Michael Smerconish and David Frum, a senior editor at The Atlantic and a contributor at CNN.