Furin is a member ofthe proprotein convertase (PC) family, which belongs to the subtilisinsuperfamily of serine proteases. As a cellular protease, Furin processes avariety of proproteins in secretory pathway compartments by cleaving after Arg-Xaa-Lys/Arg-Arg-like motifs, which usually reside at the end of the pro regions ofthese proproteins.

Source:

Chinese HamsterOvary cell line, CHO-derived

Form:

Supplied as a 0.2 μmfiltered solution in Tris, CaCl2, NaCl, Brij-35 and Glycerol.

N-terminal Sequence:

Asp108, Cys198,Ser239, Glu684

Molecular Weight:

77 kDa

Activity:

Measured by itsability to cleave the fluorogenic peptide substrate pERTKR-AMC. The specificactivity is > 150 pmoles/min/μg, as measured under the described conditions.