Our expert team, utilizing the Multi-Electrode Array (MEA) platform, developed and validated a NSF SET to address a number of primary functional aspects of neuronal excitability and neurotransmission in acute brain slices from rodents.

PC SET (ProConvulsive Package)PC SET

DETECT PRO-CONVULSIVE SIDE EFFECT OF YOUR MOLECULE

Our electrophysiologists can establish a compound’s “pro-convulsive profile”. They use Multi-Electrode Array (MEA) recordings to investigate pro-convulsive activity of compounds in acute hippocampal slices. Slices for chronic toxicity studies are prepared from vehicle-treated and compound-treated animals. This package can be a substitute to certain in vivo tests.

The pro-convulsive package provides clients with 3 types of recordings:

Population Spikes shape

CA1 neurons firing activity

Epileptiform Discharges

With NEUROSERVICE’s pro-convulsive platform, you can:

Observe: pro-convulsive activity over the entire hippocampal slice.

Establish: a compound’s pro-convulsive profile in the context of reference pro-convulsive molecules.

Identify: weak pro-convulsive properties by co-exposure with a sub-threshold concentration of a reference pro-convulsive compound.

Anti-convulsive compounds that suppress or prevent pro-convulsive activities can also be profiled using similar recording protocols.

Time and cost can be compared to in vivo assays, increasing the number of compounds that can be profiled at earlier stages of development.

4 weeksfor final report (3 for top-line results)

IDENTIFYpotential pro-convulsive effect of compounds in the Central Nervous System (CNS)

GOS SET (Gamma Oscillations Package)GOS SET

Gamma Oscillations: benefit from a translational biomarker

Neuronal rhythms are disordered in schizophrenia, epilepsy, autism, ADHD, Alzheimer and Parkinson Disease.
Oscillations in the gamma frequency range are assumed to be responsible for information transfer and their integration between different brain areas.
This set of in vitro assay provides a direct answer about your compound efficacy on a complex neuronal network, as well as a translational biomarker for further in vitro/in vivo investigations.

DRG Na SET (DRG Sodium Package)DRG Na SET

Detect effects on DRG Na+ channels

Sodium channels are involved in pain associated with neuropathy, diabetes, osteoarthritis and surgery.
This innovative in vitro recording package provides functional data to enable decision making in pain research program.

How ?

Evaluation of 1 compound at 1 concentration on 3 predictive tests

6 freshly dissociated DRG neurons from rats

Less quantity of compound required

4 weeksfor final report

Identifycompound effect on voltage-dependent sodium channels

Sodium channelmodulation on freshly dissociated DRG neurons

ELECTROPHYSIOLOGICALrecording in “whole-cell” configuration using the Patch-Clamp technique