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I have clicky joints and I'm on a low carb diet trying to be on a low carb diet. I don't think they are related. I think one is about me being an out of shape old man and the other is about my joints clicking.

But I am not really a doctor. I would talk to a real doctor if the clicky is bugging you.

What disease is it? I remember him saying that both he and his daughter have an "autoimmune disease" but which one is it?

I have (had?) an autoimmune disease - sarcoidosis. Does he and his daughter have that? Or maybe they both have AIDS? They are not specific, so how is anyone to judge whether this diet is useful for them as well?

Just FYI. AIDS isn't an autoimmune disorder. Autoimmune diseases are where your own immune system attacks otherwise healthy parts of your body. In AIDS you immune system stops defending you.

__________________REJ (Robert E Jones) posting anonymously under my real name for 30 years.

Make a fire for a man and you keep him warm for a day. Set him on fire and you keep him warm for the rest of his life.

And while Insulin Resistance goes hand in hand with T2, it's a common genetic problem. No reason you can't have both T1 and the genes for IR.

It's a fairly recent development(recent decades) that it has been realized that Type 1's can also develop insulin resistance to their exogenous insulin. It's now pretty common for Type 1's to Take metformin.

Low carb is proving very valuable for T1's, not just for reducing insulin intake but for reducing spikes (increasing time spent in range). Even now in the age of pumps and CGM's , it's not always easy to maintain a good A1c while also avoiding hypos.

It's a fairly recent development(recent decades) that it has been realized that Type 1's can also develop insulin resistance to their exogenous insulin. ......

Except for the "exogenous" part. Modern insulins are recombinant HUMAN insulin. The resistance is also ti their endogenous insulin (if they have any).

And it is this genetic insulin resistance (IRS-1 gene) that raises insulin levels so high it acts like a growth hormone. Grows thicker artery walls, causing arteriosclerosis. And poor peripheral circulation. And also tendon sheaths- carpal tunnel and trigger fingers. Bad discs too. And guess how Statins really work? They lower insulin resistance.

The bad IRS-1 gene is in 40% of Caucasians, 50% of Africans. Death rate from heart attacks- 40% for Caucasians, 50% for Africans. Coincidence?

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It's a fairly recent development(recent decades) that it has been realized that Type 1's can also develop insulin resistance to their exogenous insulin. It's now pretty common for Type 1's to Take metformin.

Low carb is proving very valuable for T1's, not just for reducing insulin intake but for reducing spikes (increasing time spent in range). Even now in the age of pumps and CGM's , it's not always easy to maintain a good A1c while also avoiding hypos.

Hmm, does metformin lower resistance directly, or does it lower sugars and the body lowers insulin levels? Now, wait... T1s have no ability to lower insulin since they don't make any to begin with.

Supposedly Metformin works by lowering insulin resistance,( which is of course the big issue for T2's), and also by discouraging your liver from giving you those glucose boluses, most often expressed as "dawn phenomenon". Sometime T1's develop resistance to the insulin they are taking though, in these cases they may also take Met. Most T1's don't have any insulin resistance though, so don't take Met.

I'm T2 myself and love the Met. If you ever get the urge to try it again keep in mind that those side effects go away after a few months for a majority of people.

__________________"As long as it is admitted that the law may be diverted from its true purpose -- that it may violate property instead of protecting it -- then everyone will want to participate in making the law, either to protect himself against plunder or to use it for plunder. Political questions will always be prejudicial, dominant, and all-absorbing. There will be fighting at the door of the Legislative Palace, and the struggle within will be no less furious." - Bastiat, The Law

Supposedly Metformin works by lowering insulin resistance,( which is of course the big issue for T2's), and also by discouraging your liver from giving you those glucose boluses, most often expressed as "dawn phenomenon". Sometime T1's develop resistance to the insulin they are taking though, in these cases they may also take Met. Most T1's don't have any insulin resistance though, so don't take Met.

I'm T2 myself and love the Met. If you ever get the urge to try it again keep in mind that those side effects go away after a few months for a majority of people.

The REAL problem is not that "lowering insulin resistance,( which is of course the big issue for T2's),". The real deal is that Insulin Resistance is the culprit for 40% of people, even if it is not bad enough to cause diabetes. Lowering IR enough that your diabetes is solved in not good enough. Read about "pseudo acromegaly".

And just a few months of ******** my pants? Really? No, we need to lower IR without messing with our liver function. Check out how the IRS gene defect lowers IGF levels, and that boosting IGF lowers sugar .

My IGF is 9th percentile. Too bad so many lab tests use "5-90% is the normal range", not subjective studies of morbidity.

__________________Great minds discuss ideas.
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By all means find a cure for insulin resistance, you'll get no argument from me.

I think you have the wrong idea about Metformin though. It is extremely beneficial for the health of everyone who takes it, and not just diabetics. Over the decades the life extending properties of Metformin have been noticed, so much so the it is the first drug ever approved by the FDA for life extension studies in humans. http://www.lifeextension.com/magazin...proval/page-01

Personally I never "**** my pants" when I started taking Met, I had occasional diarrhea for a couple weeks.

I think you have the wrong idea about Metformin though. It is extremely beneficial for the health of everyone who takes it, and not just diabetics.

Lots of people may well benefit from it, but given its rather serious side effects (well beyond diarrhea), it would be quite extraordinary if there was nobody taking it who shouldn't be.

For example, metformin interferes with androgen receptors. This makes it more difficult to maintain, let alone build, muscle mass. But building muscle is one of the best ways to increase insulin sensitivity, and it has a bunch of other health benefits as well (increased bone density, better balance, protein reserves against health problems, etc). The loss of muscle mass can compound a lot of health problems, including those from diabetes.

__________________"As long as it is admitted that the law may be diverted from its true purpose -- that it may violate property instead of protecting it -- then everyone will want to participate in making the law, either to protect himself against plunder or to use it for plunder. Political questions will always be prejudicial, dominant, and all-absorbing. There will be fighting at the door of the Legislative Palace, and the struggle within will be no less furious." - Bastiat, The Law

Lots of people may well benefit from it, but given its rather serious side effects (well beyond diarrhea), it would be quite extraordinary if there was nobody taking it who shouldn't be.

For example, metformin interferes with androgen receptors. This makes it more difficult to maintain, let alone build, muscle mass. But building muscle is one of the best ways to increase insulin sensitivity, and it has a bunch of other health benefits as well (increased bone density, better balance, protein reserves against health problems, etc). The loss of muscle mass can compound a lot of health problems, including those from diabetes.

Interesting. I haven't heard of this side effect. A brief bit of googleing shows this effect preventing prostate cancer, but I'm not seeing where it interferes with muscle mass, do you have a link? I'm not doubting you, I'm just interested to read about it.

There are conditions where Metformin use is contraindicated, in particular kidney disease. Anyone with a GFR <90 should not use it.

Should it be used by the general public for the purpose of life extension? That is yet to be determined, it's what the trials are all about.

Interesting. I haven't heard of this side effect. A brief bit of googleing shows this effect preventing prostate cancer, but I'm not seeing where it interferes with muscle mass, do you have a link? I'm not doubting you, I'm just interested to read about it.

I don't think that's the only way it can interfere with muscle growth, though. It doesn't make it impossible to grow muscle, people can and do get stronger on metformin, but it can make it harder. The trade off may well be worth it for a lot of diabetics, and for people who are sedentary that might not make much difference, but you probably shouldn't be taking it if you don't have a compelling reason to.

__________________"As long as it is admitted that the law may be diverted from its true purpose -- that it may violate property instead of protecting it -- then everyone will want to participate in making the law, either to protect himself against plunder or to use it for plunder. Political questions will always be prejudicial, dominant, and all-absorbing. There will be fighting at the door of the Legislative Palace, and the struggle within will be no less furious." - Bastiat, The Law

I don't think that's the only way it can interfere with muscle growth, though. It doesn't make it impossible to grow muscle, people can and do get stronger on metformin, but it can make it harder. The trade off may well be worth it for a lot of diabetics, and for people who are sedentary that might not make much difference, but you probably shouldn't be taking it if you don't have a compelling reason to.

Hormones is complicated. That defective IRS gene I speak of is Insulin Receptor Substrate gene. The substrate is also used to make the Growth Hormone Receptor. The GHR triggers the liver to make the Insulin Like Growth Factor, IGF. So, fixing the IR will also mess with the IGF system.

But more likely the hormonal side effects of metformin are caused by the lowering of IR,which would lower the body's need to put out so much insulin, and since insulin acts like IGF, it is as if the body has less IGF for growth and repair. Ans since IGF/Insulin riggers the output of other hormnone, oops, change one butterfly in China and you get hurricanes in Florida.

Insulin activates 10 genes that IGF does not. IGF activates 27 genes that Insulin does not. They have overlap, but they are not identical in action. And since the IRS defect makes bad receptors for both,....

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I know I feel much better, physically and mentally, if I shoot for less than 20g crabs and all of that from green leafy vegetables. The first week or two may suck, but once your body adapts it really feels great.

I looked up the ready-made Hormel Roast beef au jus. It's 640 calories for the container but there's sugar added, so that "meat" comes to 15 g carbs.

The UKPDS study showed that it was worthless for diabetics to try to maintain 'normal' A1C levels. Seems the savings in long term costs did not even pay for the extra meds. So now they are happy with my 7.1 A1C. Which makes me think that most of the side effects of diabetes are not caused by high sugars, but by the high insulin levels. Insulin Resistance is the culprit, high sugar is merely a symptom.

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I never understood diet instructions that said, "Don't skip meals," because it's kind of worked for me. I'm hungrier on the days I eat breakfast. I get a lot of cardio and it doesn't seem to need food to work (except swimming).

Diets consisting primarily of meat can work provided there is sufficient fat in them. Inuit diets included blubber to add both fat and vitamin C. Without enough fat in them you’d loose weight and suffer a number of other fairly serious problems.

It is not, as many woo diet advocates claim, a ketogenic diet. The processing of meat is enabled by a liver that is considerably larger than most other populations, and more frequent urination to purge the byproducts of their diet.

More importantly, they eat raw meat, which means that they get much of their dietary calorie intake not from fat or protein, but from glycogen stores in the meat and fat.

And the Inuit diet is not exclusively meat and fish. They also eat vegetable matter, mostly berries, certain wild herbs and grasses, and various tubers (often by raiding mouse food caches). Not a lot, but enough to provide the few nutrients they cannot get from meat.

Originally Posted by Minoosh

All-meat just doesn't seem like it would have been a good adaptation for hunters & gatherers. Maybe they ate a lot of bugs. Are bugs meat?

An average hunter-gatherer diet isn't all that high in meat, certainly not all-meat. There are a lot of fruits, vegetables (particularly tubers), and yeah, bugs too for some of them (fat-rich grubs and locusts most commonly, although some far-eastern cuisines are fond of ant's eggs too).

__________________"All opinions are not equal. Some are a very great deal more robust, sophisticated and well supported in logic and argument than others." -- Douglas Adams
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I looked up the ready-made Hormel Roast beef au jus. It's 640 calories for the container but there's sugar added, so that "meat" comes to 15 g carbs.

Does the 20g include dietary fiber?

Finding prepared foods without added sugar is very difficult. I tend to prepare my own meat as much as possible to avoid sauces that will have more sugar in them than I want.

I count net carbs as mentioned by Skeptical Greg. Total carbs minus fiber. Sometimes I will indulge in a sweet that is made with sugar alcohols, but I try not to make that a habit.

Leafy green veggies are fairly low, tomatoes and berries are bit higher, citrus fruits and ground veggies are off the menu for me. And while I try to keep it under 20, I more often land between twenty and fifty. I'm not the measuring type so I can't be 100% confident in that claim either.

Supposedly all of these things cleared up with her diet change. No idea how honest she's being able that, although I doubt she's lying about the hip replacement.

I think what you've done is amazing and agree with what you say, I just think it doesn't necessarily apply to this girl. Though it may apply to those who are looking to her for answers.

__________________"... when people thought the Earth was flat, they were wrong. When people thought the Earth was spherical they were wrong. But if you think that thinking the Earth is spherical is just as wrong as thinking the Earth is flat, then your view is wronger than both of them put together."
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The old, "eat less, move more" that people hate to hear and won't get you any patreons.

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__________________"As long as it is admitted that the law may be diverted from its true purpose -- that it may violate property instead of protecting it -- then everyone will want to participate in making the law, either to protect himself against plunder or to use it for plunder. Political questions will always be prejudicial, dominant, and all-absorbing. There will be fighting at the door of the Legislative Palace, and the struggle within will be no less furious." - Bastiat, The Law

With regards to her, fame is a vitalising placebo. I'm sure she thinks she feels better.

Plus, her ailments are the sort of things that can clear up of their own accord, or go in phases.

If she ate more bony fish (herring, sardines) that might improve calcium levels and osteoarthritis, but I haven't seen what sorts of meat she eats and you can do that and still eat a balanced diet.

That's a strange comment..
Can one think they feel better, without actually feeling better?

Also, getting more calcium does not improve bone health in the absence of otherwise good nutrition. Many elements of
the standard American diet ( SAD ) are calcium depleting. in that it interferes with absorption.

__________________" The main problem I have with the idea of heaven, is the thought of
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That's a strange comment..
Can one think they feel better, without actually feeling better?

Also, getting more calcium does not improve bone health in the absence of otherwise good nutrition. Many elements of
the standard American diet ( SAD ) are calcium depleting. in that it interferes with absorption.

Absorption is only a part of calcium metabolism. That is why giving calcium supplements doesn't help osteoporotics. So, many if us have calcium in the wrong places. Like arteries, heart valves, tendons, .... Our SAD diet certainly hasn't depleted our calcium.

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I knew that. It shows in xrays of my cervical vertebra. It's called "scalloped vertebra".

How to stop/fix?

There is a lot more to insulin resistance than diabetes.

Weightlifting. Stress produces adaptation. Deadlifts, performed correctly, are one of the best things you can do to protect your back.

__________________"As long as it is admitted that the law may be diverted from its true purpose -- that it may violate property instead of protecting it -- then everyone will want to participate in making the law, either to protect himself against plunder or to use it for plunder. Political questions will always be prejudicial, dominant, and all-absorbing. There will be fighting at the door of the Legislative Palace, and the struggle within will be no less furious." - Bastiat, The Law

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