The Mammalian Genome special issue on ageing

The Mammalian Genome special issue on ageing
Potter, Paul
2016-06-10 00:00:00
Mamm Genome (2016) 27:257–258 DOI 10.1007/s00335-016-9652-9 Paul K. Potter Published online: 10 June 2016 Springer Science+Business Media New York 2016 With the ever-increasing numbers of elderly people across of work on the regulation of cellular senescence which is the globe, there is a growing recognition of the beneﬁts of thought to play a central role in ageing. the study of the process of ageing and the genetic and Ageing has a direct effect on tissues and physiological environmental determinants of late-onset disease. Devel- systems that in turn inﬂuence the development of disease. oping disease model systems that allow us to explore and Banks et al. describe the changes to circadian rhythm with test mechanisms of late-onset disease, including the impact age and their consequences. In a similar vein, the theme of of the ageing process, will be critical. While a number of circadian rhythm alterations with ageing is picked up by models of age-related disease are early onset or induced Goljanek-Whysall et al. in their review of skeletal muscle and develop a rapid disease, the need for disease models dysfunction. Chris Jones highlights the need for a better that emulate the chronic and/or late-onset aspects of human understanding of
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