CXCR6 was described as a novel chemokine receptor largely based on its sequence homology to known chemokine receptor molecules. The structure contains a sequence common to chemokine receptors, which mediate their cellular effects through a G protein-coupled mechanism. A receptor known as CXCR6 was originally described for its ability to endow cells expressing it and CD4, but not other known HIV co-receptors, to be infected with both the simian immunodeficiency virus and HIV type I. Use of CXCR6 as a co-receptor for HIV viral entry appears to be determined by the structure of the HIV Env protein. Both M-tropic and T cell tropic HIV strains can infect CXCR6-expressing cells. CXCR6 is expressed in lymphoid tissues, on activated T cells and on tumor-infiltrating lymphocytes.

Catalog #

C8375-13B

Applications

Suitable for use in Flow Cytometry. Other applications not tested.

Recommended Dilution

Optimal dilutions to be determined by the researcher.

Hybridoma

NSO myeloma cells with B cells from Balb/c mice.

Absorption

482nm-564nm

Emission

675nm

Storage and Stability

May be stored at 4°C. For long-term storage, aliquot and store at 4°C. Do not freeze. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer. PerCP conjugates are sensitive to light.