The series set in the 1930s, following three friends, Little Audrey, Little Lotta, and Little Dot, defenders of the streets called Harvey Street, located in the magical city called Harvey Town, which kids rule. Audrey, Lotta and Dot loves to hanging out, having fun and fighting evil adult villains.

Trivia

The series marked the first time Little Audrey wears a blue dress, since 1958's Dawg Gawn.

This series appears to be a lot more wacky, cartoony and slapsticky than the original Little Audrey theatrical cartoons ever was, as well as making use of a wide array of various zany cartoon sound effects (mainly from the Warner Bros. and Hanna-Barbera cartoons). In fact, this series appears to have the highest level of slapstick as that of other cartoons such as Looney Tunes, Tom & Jerry, Inspector Gadget, The Lion King's Timon & Pumbaa and MGM Tex Avery cartoons.

This is one of DreamWorks Animation's television series to use sound effects from various Hanna-Barbera cartoons and Warner Bros. cartoons, the others is Turbo FAST and VeggieTales in the House.

Services in the notices range from toys, clothes, comic books, home videos, television and so on, indicating that DreamWorks Animation and NBCUniversal might be wanting to bring the Harvey Girls out of the vaults and start a multimedia franchise based off of them, entitled Little Audrey and the Harvey Girls.