Baccano!

Aboard the ship Advenna Avis in 1711, a group of alchemists summon a demon in the hopes of gaining eternal life. The demon gives them an elixir of immortality and the method of ending their existence, by "devouring" one another, and grants the summoner Maiza Avaro the formula of the elixir. Maiza and most of the alchemists decide that no one else must become immortal; only Szilard Quates opposes. The next night, the alchemists begin to disappear, devoured by Szilard. Realizing the threat posed by staying together, they scatter across the globe.

In New York City during November 1930, Szilard succeeds in recreating the elixir, only to have it stolen by young thug Dallas Genoard. The elixir continually moves around the city because of Dallas, the three mafiosi Gandor brothers, the two eccentric thieves Isaac Dian and Miria Harvent and Firo Prochainezo and his Camorra family, the Martillo, all of whom do not realize what it is. Szilard makes Dallas an incomplete immortal (meaning he still ages) to retrieve the elixir. However, the Gandor and Firo Prochainezo and his Camorra family, the Martillo, and Isaac and Miria accidentally consume the elixir. Firo falls in love with Szilard's homunculus Ennis. After she betrays Szilard by telling Firo how to devour Szilard, Firo uses the knowledge he absorbed from Szilard to save her from death. The Gandor cement Dallas to a barrel at the bottom of the Hudson River to punish him for killing Gandor members.

In late 1931, the Gandor fight the Runorata family for control of the same area. In an attempt to resolve the situation, Luck Gandor asks his adoptive brother Claire Stanfield, the legendary assassin, to travel to New York. Claire agrees to and boards the transcontinental train the Flying Pussyfoot, on which he works as a conductor. The train is hijacked by the Russo and Lemure gangs, and a battle ensues between the two gangs. Meanwhile, Jacuzzi Splot, Nice Holystone and their gang attempt to protect the passengers and fight the hijackers, while Claire assumes the identity of the Rail Tracer, a monster that eats train passengers, and slaughters much of the Russo and the Lemure. The last remaining members of the Lemure are eventually defeated by Jacuzzi's gang. The train arrives in early 1932. Meanwhile, Eve Genoard searches for Dallas, putting her at odds with Luck, who is still angry over the deaths Dallas caused, and she is caught up in the turf war. Luck secretly tells Eve where Dallas is, and with Claire's help, the turf war ends.

In 1933, Dallas is finally pulled out of the river, but shortly after, he is abducted by the Lamia, a group working for Huey Laforet. Meanwhile, Jacuzzi's operations begin to encroach on Gandor and Martillo turf. Representatives from both groups converge on Eve's home, where his gang is staying. At the same time, the Lamia arrive to enlist Jacuzzi's help; they have kidnapped Dallas to prove that immortality is possible, and convince Jacuzzi to join them. Elsewhere in New York, Mist Wall, the largest branch office of the military equipment researcher and developer Nebula, is bombed as according to Huey's plans.

The next year on Alcatraz Island, Ladd Russo, imprisoned for the slaughter aboard the Flying Pussyfoot, Firo, incarcerated for destruction of public property during the Mist Wall bombing, and Isaac, found guilty of various thefts, befriend one another and meet Huey, who was charged with treason and conspiracy years ago. Meanwhile, Christopher Shouldered, Huey's homunculus, and Graham Specter, Ladd Russo's loyal follower, cause trouble in Chicago. After, Jacuzzi and his gang return to Chicago while Ladd attempts to kill Huey.

Baccano! is somewhat powerful in its own way. Quite a few characters are effectively immortal and one character is a devil that can grant immortality as well as decapitate others with a thought. Another character was said to be able to solo the whole cast effortless despite lacking any significant supernatural ability.