Oxytocin: Trust Hormone

by Life Enthusiast Staff

Courtesy NIH/National Institute of Mental Health and World Science staff

Dec. 8, 2005

A brain chemical that boosts trust seems to work by reducing activity and
damping connections in brain circuits that process fear, a study has found.

The chemical, oxytocin, is a natural brain hormone thought to be linked to
bonding, social attachment and, some scientists believe, love. It is also the
key ingredient in a "trust potion" that researchers developed recently:
when people sniffed it, they temporarily became more trusting.

In the new study, researchers said they showed through brain scans that oxytocin
quells the brain's fear center and associated "relay stations"
in response to frightening images.

The work suggests new approaches to treating conditions involving excessive
fear in social situations, the scientists added. These conditions include social
phobia, autism, and possibly schizophrenia.

The research suggests chemicals similar to oxytocin could serve as therapies
in these disorders, added Thomas Insel, director of the National Institute of
Mental Health in Bethesda, Md., where the study was conducted.

The study, by the institute's Andreas Meyer-Lindenberg and colleagues,
appears in the December 7 issue of the Journal of Neuroscience.

Animal studies "have shown that oxytocin plays a key role in complex
emotional and social behaviors, such as attachment, social recognition and aggression,"
said Elias Zerhouni, director of the National Institutes of Health, the US agency
of which the National Institute of Mental Health is a part. "Now, for the
first time, we can literally see these same mechanisms at work in the human
brain."

The researchers started their study as a result of the "trust potion"
study reported last June by Swiss researchers. Also, previous research had linked
trusting behavior to decreased activity in a brain area called the amygdala.

Meyer-Lindenberg hypothesized that oxytocin boosts trust by suppressing the
amygdala and its fear-processing networks.

To test this idea, he asked 15 healthy men to sniff either oxytocin or a neutral
control substance before receiving a brain scan with a technology called functional
magnetic resonance imaging. The scans show which parts of the brain are stimulated
by specific activities.

While in the scanner, the men looked at angry or fearful faces and threatening
scenes, activities known to stimulate the amygdala.

As expected, the threatening pictures triggered strong amygdala activation
during the scans without oxytocin, but markedly less activity with oxytocin,
the researchers reported. The difference was especially pronounced in response
to threatening faces, they added, suggesting a key role for oxytocin in regulating
social fear.

Moreover, they found oxytocin dampened the amygdala's communication with
other brain centers thought to "telegraph" fear throughout the brain.
These sites are in the brain stem, a primitive part of the brain connected to
the spinal cord.

The results mirrored findings in rats, reported earlier this year by European
scientists, the researchers added.

"This dual mode of action of oxytocin in humans suggests a potentially
powerful treatment approach toward socially relevant fear," wrote the scientists.
This is because increased amygdala activation has been associated with social
phobia, genetic risk for anxiety and depression, and possibly with social fear
in autism.

Autistic people tend to avoid looking at faces, and doing so seems to stimulate
their amygdalas, the researchers added. Meyer-Lindenberg said future studies
may thus test oxytocin as a treatment for such social anxiety symptoms in autistic
children.

Future research may also examine how oxytocin affects the amygdala in women,
and the function of related hormones, such as a chemical called vasopressin,
Meyer-Lindenberg said. Another subject of scrutiny, he added, will be how genetic
variants in these hormones affect brain function.

Scientists Make "Trust Potion"

Courtesy Nature and World Science staff

June 1, 2005

Imagine if you could bottle trust, ready to be unleashed the next time you
want someone to lend you some money. Researchers say they have done just that,
having developed a potion that, when sniffed, makes people more inclined to
trust someone else to look after their cash.

The key chemical is oxytocin, a hormone that is known to promote social interactions
such as pair bonding in animals, said Ernst Fehr of the University of Zurich,
Switzerland, and his colleagues, who reported the finding in this week's
issue of the research journal Nature.

They studied people playing a trust game in which an "investor"
could choose how many credits to hand over to a "trustee," who would
then decide how much to hand back after the stake had been quadrupled in size.

Investors were more trusting after inhaling oxytocin, the researchers found.
Moreover, they added, this effect was no longer seen when the trustee was replaced
with a computer, suggesting oxytocin functions to promote social interaction
rather than simply making people more likely to take risks.

Oxytocin is also believed to be a hormone that may underlie romantic love.

The trust potion finding "opens up possibilities for investigating conditions
in which trust is either diminished, as in autism, or augmented," wrote
Antonio Damasio of the University of Iowa, Iowa City, in a commentary in the
journal.