To investigate the effect of viral inoculation by adenovirus 5 (Ad5) on body composition in a mouse model.

DESIGN:

Longitudinal monitoring before and after a single injection of virus or saline.

SUBJECTS:

Two groups of CD1 mice, one group given a single intraperitoneal dose of Ad5 and the control group, saline.

MEASUREMENTS:

Bodyweights and food intake were recorded before and up to 21 weeks after inoculation. At the end of the study, whole-body 1H magnetic resonance spectroscopy (MRS) and localised in vivo 1H MRS spectroscopy of the liver was performed to assess whole-body adiposity and intrahepatic lipid content, respectively.

RESULTS:

Ad5-treated animals gained significantly more weight over a period of 21 weeks after inoculation than the controls, 21.8 g (18.8–25.0) and 18.8 g (17.3–19.8) respectively, (P<0.05). The gain in bodyweight in the former animals arises from increased deposition of adipose tissue as measured by whole-body 1H MRS. Adiposity was 6.7% (3.10–11.20%), and 2.40% (0.85–5.65%) for the Ad5-treated and control animals, respectively (P<0.05). No significant difference in intrahepatic lipid content or food intake was observed between the two groups.

CONCLUSION:

The significantly higher percentage of adipose tissue in the Ad5-treated mice suggest viral infection may play a contributory role to a predisposition to obesity, although its contribution relative to other factors remains to be determined.

The Potential of Omega-3 Supplementation to Reduce Muscle-Inflammation after Muscle-Damaging ExerciseKyriakidou, Y., Kantorovich, R.C., Bell, J.D., Monterisi, S. and Dolci, A. 2017. The Potential of Omega-3 Supplementation to Reduce Muscle-Inflammation after Muscle-Damaging Exercise. ACSM Annual Meeting, World Congress on Exercise is Medicine & World Congress on the Basic Science of Exercise and the Brain. Denver, Colorado 30 May - 03 Jun 2017 American College of Sports Medicine. doi:10.1249/01.mss.0000518523.15295.1c