g during the first eight weeks appear to be
losing additional weight as the treatment is continued past the six-month mark,
said Gadde, although researchers have not completed analysis of these data yet.
"Here we have a well-tolerated drug that has shown significant clinical benefits
in reducing weight," Gadde said. "While we have to approach the results
cautiously because the long-term results are not completed, we are very excited
about the potential this drug has for treating obesity."

A newer-generation anti-depressant, bupropion SR is in a class by itself and has
no appreciable effect on the brain chemical serotonin, as do the majority of
newer anti-depressants. Bupropion SR works by increasing available amounts of
norepinephrine and dopamine, two other brain chemicals implicated in the reward
and pleasure pathways.

Gadde says its unique mechanism of action may account for why patients remark
that bupropion does not suppress their appetite, but rather helps them feel
satisfied more easily.
"A lot of patients have said that, while on the drug, they can eat a small piece
of pie and feel satisfied, although not necessarily full. So it appears they
feel rewarded much quicker than they normally do without the drug."
The only side effect commonly reported in this study was dry mouth. Burpopion SR
is not approved by the FDA for weight loss and should not be used by patients
with seizure disorders, anorexia or bulimia, Gadde said.

The study will continue for another 18 months. Data also are being collected on
bone density and lean muscle mass. Preliminary results should be available
later this summer.

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