I admit I have not read any research on EC(A) in quite some time, but I am positive I read reasearch at one time that suggested the A offered little to no advantage. Is there conflicting research in this area?

I admit I have not read any research on EC(A) in quite some time, but I am positive I read reasearch at one time that suggested the A offered little to no advantage. Is there conflicting research in this area?

I believe I read, that only in very obese individuals the mechanism of action of aspirin is important. Could be super duper wrong tho lol

Ephedrine increases the release of noradrenaline. Noradrenaline then binds to the adrenergic receptor. A protein is then split and one half attaches to the activated adrenergic receptor and the other half binds to adenylate cyclase and this becomes activated which results in the production of cAMP and thus the thermogenic cascade. Now what does aspirin contribute? Noradrenaline is inhibited by prostaglandins. So when you take ephedrine you will get an increase in noradrenaline but you wont get an as increased cAMP output because prostaglandin will be inhibiting noradrenaline. Asprin inhibits the peripheral synthesis of prostaglandins so by taking aspirin you create the enviroment to help maximize your results.

"The only good is knowledge and the only evil is ignorance." - Socrates

Ephedrine increases the release of noradrenaline. Noradrenaline then binds to the adrenergic receptor. A protein is then split and one half attaches to the activated adrenergic receptor and the other half binds to adenylate cyclase and this becomes activated which results in the production of cAMP and thus the thermogenic cascade. Now what does aspirin contribute? Noradrenaline is inhibited by prostaglandins. So when you take ephedrine you will get an increase in noradrenaline but you wont get an as increased cAMP output because prostaglandin will be inhibiting noradrenaline. Asprin inhibits the peripheral synthesis of prostaglandins so by taking aspirin you create the enviroment to help maximize your results.

I understand the scientific thoery of the asprin, but there are studies that have been done and E, C, and A that show little to know benefit to the A. Does anyone know of a study that has been done that shows a benefit to including the A?

I understand the scientific thoery of the asprin, but there are studies that have been done and E, C, and A that show little to know benefit to the A. Does anyone know of a study that has been done that shows a benefit to including the A?

I have read that in several places as well, in for an answer.

Alternate question, how far apart from food should this be used

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I understand the scientific thoery of the asprin, but there are studies that have been done and E, C, and A that show little to know benefit to the A. Does anyone know of a study that has been done that shows a benefit to including the A?

There are tons of studies man. Aspirin is the least beneficial component of the stack, but it's still beneficial.

Do the Sida Cordifolia products you can buy on several uk shops contain real ephedra alkaloids? I'm wondering since you can get those very cheap on a uk bulkpowder site. On their websites it states 10% active alkaloids but not what these alkaloids are.

I understand the scientific thoery of the asprin, but there are studies that have been done and E, C, and A that show little to know benefit to the A. Does anyone know of a study that has been done that shows a benefit to including the A?

Do the Sida Cordifolia products you can buy on several uk shops contain real ephedra alkaloids? I'm wondering since you can get those very cheap on a uk bulkpowder site. On their websites it states 10% active alkaloids but not what these alkaloids are.

"There was no significant differences between the groups that received aspirin and the groups that did not. We conclude that aspirin does not potentiate the acute thermic effect of ephedrine and caffeine."

"it was demonstrated that aspirin does not potentiate the thermogenic response to ephedrine in lean women and only slightly so in obese women. The increase seen in this study represented a 1.2 kcal per hour increase in metabolism for lean women and a 2.4 kcal per hour increase in metabolism in obese women over use of ephedrine alone"

Horton TJ, Geissler CA. Aspirin Potentiates the Effect of Ephedrine on the Thermogenic Response to a Meal in Obese but not Lean Women. Int J Obes, 1991 May;15(5):359-366.

The second study does show a very, very small advantage in the obese test subjects as compared to the lead test subjects. I will admit that I have not read the complete studies. Maybe their methodologies of testing comprimise the validity of their findings?

I should add I am not anit-asprin. I'm just hasing out some of the info I have read that suggest the asprin is of little to no benefit. Apparenly there have been reseach studies that prove otherwise. I guess I will have to search for those now.

This one had too much aspirin (300mg) and not enough caffeine (100mg). Caffeine antagonizes adenosine and phosphodiesteraseand result are best seen when 200mg are combined with ephedrine (http://www.ncbi.nlm.nih.gov/pubmed/8384179)

Originally Posted by FireRescue

Horton TJ, Geissler CA. Aspirin Potentiates the Effect of Ephedrine on the Thermogenic Response to a Meal in Obese but not Lean Women. Int J Obes, 1991 May;15(5):359-366.

This one didnt even combine caffeine in. It compares E vs EA which is just silly really. As mentioned above caffeine plays a very important role in ECA.

"The only good is knowledge and the only evil is ignorance." - Socrates

Ephedrine increases the release of noradrenaline. Noradrenaline then binds to the adrenergic receptor. A protein is then split and one half attaches to the activated adrenergic receptor and the other half binds to adenylate cyclase and this becomes activated which results in the production of cAMP and thus the thermogenic cascade. Now what does aspirin contribute? Noradrenaline is inhibited by prostaglandins. So when you take ephedrine you will get an increase in noradrenaline but you wont get an as increased cAMP output because prostaglandin will be inhibiting noradrenaline. Asprin inhibits the peripheral synthesis of prostaglandins so by taking aspirin you create the enviroment to help maximize your results.

So what is the recommended dose for aspirin to include? Bit the bullet and ordered kaizen EC in bulk as it was cheaper. 12 bottles ephedrine and enough caffeine pills to make the 200/24 doses with it. No idea how to dose aspirin though, someone help an ECA virgin out?

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So what is the recommended dose for aspirin to include? Bit the bullet and ordered kaizen EC in bulk as it was cheaper. 12 bottles ephedrine and enough caffeine pills to make the 200/24 doses with it. No idea how to dose aspirin though, someone help an ECA virgin out?

So what is the recommended dose for aspirin to include? Bit the bullet and ordered kaizen EC in bulk as it was cheaper. 12 bottles ephedrine and enough caffeine pills to make the 200/24 doses with it. No idea how to dose aspirin though, someone help an ECA virgin out?

25/200/81

25/200

25/200

"The only good is knowledge and the only evil is ignorance." - Socrates

Thank you both. Interested to see how this works out for me as it will be replacing my alphamine doses. Wish I could just use 1.5 scoops alphamine as my caffeine dose in this haha. Giving it 30 days then a much needed stim break

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Thank you both. Interested to see how this works out for me as it will be replacing my alphamine doses. Wish I could just use 1.5 scoops alphamine as my caffeine dose in this haha. Giving it 30 days then a much needed stim break

Not recommended and I'm not recommending it, but I've (along as a few others on this board) used Alphamine as my caffeine choice while using ephedrine.