Most organisms living in the presence of oxygen use it to deal with the toxic
effects of superoxide. The human body contains about 10 mg of manganese, which
is stored mainly in the liver and kidneys. The classes of enzymes that have
manganese cofactors include oxidoreductases, transferases, hydrolases, lyases,
isomerases, ligases, lectins, and integrins. The best known manganese-containing
polypeptides may be arginase, the diphtheria toxin, and Mn-containing superoxide
dismutase (Mn-SOD).

Mn-SOD is the type of SOD present in eukaryotic mitochondria, and also in most
bacteria. Manganese is also important in photosynthetic oxygen evolution in
chloroplasts in plants (photosynthesis). Most broad-spectrum plant fertilizers
contain manganese.

Though adequate amounts are helpful, too much can be toxic to the brain and
nerves.

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*This statement has not been evaluated by the Food and Drug administration. This product is not intended to diagnose, treat, cure or prevent any disease. The information provided on this site is intended for your general knowledge only and is not a substitute for professional medical advice or treatment for specific medical conditions.