The first confrontation between the Left Opposition and the troika occurred in October 1923 – January 1924, first secretly and then, from early December on, openly. The troika won decisively at the XIII Party Conference in January 1924 and its victory was reaffirmed at the XIIIth Party Congress in June 1924. The second confrontation took place in October–December 1924 during the so-called "Literary Discussion" and ended with the removal of Trotsky from his ministerial post on 6 January 1925.

With Trotsky largely marginalized, Kamenev and Zinoviev had a falling out with Stalin in early 1925. They formed the New Opposition, but were defeated by Stalin, who was again supported by Bukharin and Rykov, at the XIVth Party Congress in December 1925. After their defeat, Zinoviev and Kamenev joined forces with Trotsky's Left Opposition in what became known as the United Opposition. In July–October 1926, the United Opposition lost out to Stalin, and its leaders were expelled from the ruling Politburo. In October 1927, the last Opposition members were expelled from the Communist Party Central Committee, and in November 1927 Trotsky and Zinoviev were expelled from the Party itself. In December 1927, the XVth Party Congress declared Left Opposition and Trotskyist views to be incompatible with Party membership and expelled all leading oppositionists from the Party.

After the expulsion by the XVth Congress, Zinoviev, Kamenev and their supporters surrendered to Stalin, "admitted their mistakes" and were readmitted to the Communist Party in 1928, although they never regained their former influence and eventually perished in the Great Purge. Trotsky and his supporters, on the other hand, refused to bow to Stalin and were exiled to remote areas of the Soviet Union in early 1928. Trotsky was eventually expelled from the country in February 1929. His supporters remained in exile, but their resolve began to waver in 1929 as Stalin turned against Bukharin and Rykov and adopted the policy of collectivization, which appeared to be close to the policies that the Left Opposition advocated earlier. The Left Opposition attempted to field opposition candidates against the official Communist Party candidates in the 1929 elections, but to no avail.[1] Most (but not all) prominent Left Opposition members recanted between 1929 and 1934, but perished during the Great Purge of the mid-late 1930s along with the oppositionists who remained unrepentant.

In the meantime, Trotsky founded the International Left Opposition in 1930. It was meant to be an opposition group within the Comintern, but members of the Comintern were immediately expelled as soon as they joined (or were suspected of joining) the ILO. The ILO therefore concluded that opposing Stalinism from within the communist organizations controlled by Stalin's supporters had become impossible, so new organizations had to be formed. In 1933, the ILO was renamed the International Communist League (ICL), which formed the basis of the Fourth International, founded in Paris in 1938.

Andrei Bubnov (1883–1940), signed the Declaration of the 46 in October 1923, but defected to Stalin soon thereafter. Later head of the Communist Party organization within the Red Army and then People Commissar (minister) of Education. Expelled from the Party Central Committee in November 1937, arrested and perished in the Great Purge.