Gamma-enolase, also known as enolase 2 (ENO2) or neuron specific enolase (NSE) is an enzyme that in humans is encoded by the ENO2 gene. Gamma-enolase is a.phosphopyruvate.hydratase. Gamma-enolase is one of the three enolase isoenzymes found in mammals. This isoenzyme, a homodimer, is found in mature neurons and cells of neuronal origin. A switch from alpha enolase to gamma enolase occurs in neural tissue during development in rats and primates.