Multiphasic force fields were utilized by the crew of the USS Equinox in 2376 to contain the nucleogenic lifeforms which were attacking the crew. They first utilized this technology in the form of a multiphasic chamber, which they used to convert the lifeforms into a source of power to augment their propulsion system. Later, the crew of the USS Voyager modified their own field generator to emit multiphasic frequencies, in an attempt to construct a latticework of multiphasic force fields around the ship. The crew of the Equinox were able to beam Voyager's generator onto their own ship and integrate it, however, for the purpose of continuing their criminal experiments. (VOY: "Equinox")

The interstellar fight promoter Penk utilized multiphasic force fields on his vessel, in order to prevent any outside vessel from using transporters to gain access. This prevented the Voyager crew from rescuing Seven of Nine in 2376, whom Penk had kidnapped and forced to participate in hand-to-hand combat. When the Voyager crew began targeting Penk's signal generators in an attempt to prevent the transmission of the fight, Penk was forced to reroute power from the force fields to the generators, allowing the crew to beam Seven aboard and escape. (VOY: "Tsunkatse")