4Richard F. HeckEi-ichi NegishiAkira SuzukiEl Premio Nobel de Química 2010 fue otorgado a los científicos Richard F. Heck (EE.UU.), Ei-ichi Negishi (Japón), y Akira Suzuki (Japón), por “las reacciones de acoplamiento cruzado catalizadas por paladio en síntesis orgánica”“Palladium-catalyzed reactions are in fact strongly dependent on a number of factors such as the nature of stabilizing ligands (as well as their presence or absence), bases, additives, the combination of them, solvents, and temperature. All of these factors combine to afford a toolbox of tunable reaction conditions that make palladium chemistry so flexible and, to some extent, unpredictable, leaving room for an uninterrupted discovery of new, exciting chemistry despite the vast amount of studies developed so far”

5Synthesis and Functionalization of Indoles Through Palladium-Catalyzed ReactionsGENERAL STRATEGIES1. Construction of the pyrrole ring based on the utilization, as precursors, ofcompounds containing nitrogen nucleophiles and carbon-carbon triple bonds1.1. Cyclization of Alkynes: disconnection a

14GENERAL STRATEGIES1. Construction of the pyrrole ring based on the utilization, as precursors, ofcompounds containing nitrogen nucleophiles and carbon-carbon triple bonds

15Synthesis and Functionalization of Indoles Through Palladium-Catalyzed ReactionsGENERAL STRATEGIES2. Construction of the pyrrole ring based on the utilization, as precursors, ofcompounds containing nitrogen nucleophiles and carbon-carbon double bonds2.1. Disconnection e

19Synthesis and Functionalization of Indoles Through Palladium-Catalyzed ReactionsGENERAL STRATEGIES2. Construction of the pyrrole ring based on the utilization, as precursors, ofcompounds containing nitrogen nucleophiles and carbon-carbon double bonds