It should have directions on the label, but for pre-menopausal women, you typically apply 1/4 to 1/2 tsp. daily for the last 14 days of your cycle. It worked really well for me, but just to warn you, some women are hypersensitive to the effects of progesterone. I cannot take Provera because it gives me really bad pressure and cramps, as in keeps me up all night pressure and cramps. Progesterone cream does, too, but to a lesser extent - I'm going back to that after 3 mons. on Provera. I bought Source Naturals from Amazon.com.