IF's and skin

1) Does anyone know if skin that is misoriented, freeze artifact....any other problems once frozen can be thawed and refrozen again?

2) Would thawing/refreeze affect the IF staining afterwards?

3) If a skin has freeze artifact and if it can be thawed, does it need to be rolled in talc powder before refreezing? (Muscle biopsies that are thawed/refrozen are rolled in talc powder to get rid of freeze artifact.)

I'm hoping for some quick, good advice before I address a problem at work.
Thanks to whomever can help.