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Abstract

Absolute myocardial blood flow (MBF) and myocardial flow reserve (MFR) provide incremental
diagnostic and prognostic information over relative perfusion alone. Recent development
of dedicated cardiac SPECT cameras with better sensitivity and temporal resolution
make dynamic SPECT imaging more practical. In this study, we evaluate the measurement
of MBF using a multipinhole dedicated cardiac SPECT camera in a pig model of rest
and transient occlusion at stress using 3 common tracers: (201)Tl, (99m)Tc-tetrofosmin,
and (99m)Tc-sestamibi.