"ICAPO seeks to ensure the widest possible integration of alternative methods in the OECD's influential guidelines and programmes."

Welcome

NEW: OECD makes AOP Knowledge Base and AOP Wiki publicly available

September 25 the OECD released the Adverse Outcome Pathway Wiki, part of a larger set of tools termed the AOP Knowledge Base. The Wiki is the first in a set of tools that will allow the building of Adverse Outcome Pathways via scientific crowd-sourcing. It is envisioned that collecting available data on chemical-response and response-response interactions and organizing these data into an AOP framework will speed progress in predicting the toxicity of chemicals without whole animals.

Learn more about the AOP Wiki here and the OECD AOP Program here. The scientific literature is now replete with examples of particular AOPs and uses for them. This paper provides a list of key resources you may wish to consult.

About ICAPO

The International Council on Animal Protection in OECD Programmes (ICAPO) seeks to ensure the widest possible integration of alternative methods in the Organisation for Economic Co-operation and Development’s (OECD) influential guidelines and programmes. The OECD is an economic alliance of 30 of the world's industrialised countries. Based in Paris, the OECD co-ordinates the development of standardised chemical testing guidelines which are then adopted by the member countries. The OECD also co-ordinates the development of chemical testing programmes, such as its current programme on endocrine disruptors.

The OECD maintains the QSAR Toolbox, which is a set of computational tools that can help users group chemicals into categories to fill information gaps without new testing. QSARToobox.org contains instructions on how to download the software, which is freely available, and tutorials and guidance documents for filling specific endpoints. ICAPO has contributed financial and policy support to the development of the toolbox.