I've had great luck with H4350 (RL17 speed) in 30-06 up to 165grn bullets. Now the 308 is a different beast, mine all like Varget or RL15 with all bullets. You can load a 30-06 with Varget and heavier bullets, but I have not tried it. My advice use two powders for the the 30-06 and 308.

IMR-4064 and IMR-4350 are 2 of the most stocked powders I use. I'd have to give the edge to 4064 as my most used. It is a great powder in almost every cal I reload for, from 223 to 30-06. It is my powder of chioce for my 3 tactical 308 rifles, and it's the most used powder I have ever used in my 30-06 target and hunting rifles going on 32 years so far.