<bold>BACKGROUND</bold> <br> Migraine is an episodic neurological disorder that affects 12% of Americans and millions worldwide. Chronic migraine (CM) as ≥15 headache days per month with ≥8 days per month that meet criteria ...

<bold>Background</bold>: The safety of bevacizumab in older metastatic colorectal cancer (mCRC) patients is not well understood. The purpose of this analysis was to determine the prevalence of treatment–associated adverse ...

The studies that are presented in this dissertation have; (i) established a mechanism by which warfarin dose response is modulated by VKORC1 genotype under optimized conditions for kinetic analysis of human vitamin K epoxide ...

This work is a characterization of small molecule azole-based inhibitor interactions in cytochrome P450 (CYP) using a complement of biophysical methodologies to provide molecular level details of the underappreciated ...

<underline>A Comparison, Evaluation and Accuracy Assessment of the Fluidigm <super>(TM)</super> Platform in Genotyping Common and Rare variants in an Alaska Native Population</underline> by Joseph Yracheta Pharmacogenomics ...

Mass spectrometry is a powerful proteomics tool. Advancements in instrumentation and data acquisition techniques allow researchers to identify and quantify thousands of proteins from cellular samples in a high throughput ...

Lapatinib was the first orally active dual tyrosine kinase inhibitor (TKI) of the epidermal growth factor receptor (EGFR, ErbB1) and human epidermal receptor 2 (HER2, ErbB2) to be approved by the US Food and Drug Administration ...

INTRODUCTION: Diabetic Macular Edema (DME) is the leading cause of blindness amongst working age adults in most developed countries. Diagnosis and treatment of DME involves many visits to specialists, numerous medications, ...

HIV/AIDS education, testing, and treatment have thus far failed to cease the pandemic spread of the HIV virus. HIV prevention is hindered by a lack of protective options beyond the ABC approach of abstinence, being faithful, ...

HIV/AIDS education, testing, and treatment have thus far failed to cease the pandemic spread of the HIV virus. HIV prevention is hindered by a lack of protective options beyond the ABC approach of abstinence, being faithful, ...

The activity of the drug-metabolizing enzyme cytochromes P450 3A (CYP3A) varies up to 20-fold between individuals. The interindividual variability may be due to both genetic variations and factors such as age, diet, ...

<bold>ABSTRACT</bold> <bold>Background</bold> In the last several years three new anticoagulant options have come on to the market, altering the risk/benefit profile of stroke prevention therapy. The development of useful ...

Fish oil has been widely studied for its protective effects against heart disease. These effects are attributed to omega-3 PUFA content, which are also found in sea mammals in addition to fish. The mechanism by which ...

The calcineurin inhibitors (CNI) — cyclosporine A (CsA) and tacrolimus remain the backbone of immunosuppression therapy for most organ transplant patients despite their serious side effects, such as chronic calcineurin ...

Warfarin therapy is highly effective in treating both atrial fibrillation and deep vein thrombosis. Currently, more than 20 million Americans are receiving warfarin therapy. However, increased risk of adverse events are ...