2 780 S. Jeka et al. Ultrasound imaging is one of the most accessible imaging studies in medicine. It is associated with the low cost of such an examination and the absence of most of the contraindications to its execution, as are in case of other imaging techniques, especially X-ray and CT. The universality and the availability of this test have contributed to the very dynamic development of ultrasonography. Modern ultrasound devices can produce high resolution images, thanks to new technical solutions in image analysis, construction of a high frequency head up to 18 Mhz, or by using second generation ultrasound contrast agents. With the improvement of the quality of imaging, the range of ultrasonography applications is also expanding. In rheumatology interventions and treatments under ultrasound examination, inter alia, punctures, and administration of drugs have become the standard. Also, the monitoring of changes using ultrasound during the course of rheumatic diseases is an increasingly frequent practice. Modern methods of imaging in ultrasound allow precise tracking of inflammatory changes occurring in the synovial membrane and cartilage pannus, presence of inflammatory granulation tissue or detection of erosions, which are not yet visible on a classical X-ray. This is particularly important in the case of rheumatoid arthritis (RA), in which early diagnosis is extremely difficult due to a lack of sensitive and specific methods of diagnosis [1, 2]. The majority of rheumatic diseases lead to disorders of synovium function. In the presence of excessive amounts of inflammatory fluid in the joints, tendon sheaths and burs synovium become clearly visible by ultrasound. In addition, the swelling or hypertrophy, and the increased visibility of the granuloma have caused a growth of the importance of this type of test in the diagnosis and monitoring of rheumatoid arthritis and other rheumatic diseases. Unfortunately, the opportunities offered by new developments in the field of ultrasound are still not fully used in rheumatological practice. In this state of affairs, rheumatologists lack a sufficient level of knowledge of ultrasonography and clear criteria for assessing ultrasound [3]. While the second problem s solution is not easy, the first problem can be solved quite easily. Discussion New Methods Used in Ultrasound Increasing computing power used for analyzing the signal collected by the ultrasonographic head and increasing the frequency of the ultrasound emitted are the most obvious ways to improve the quality of images obtained during the test. Of course, such improvements in image quality do not require any medical expertise in the field of ultrasound, because they would not have any effect on how the test is performed. Unfortunately, the development of ultrasound devices in this direction has its limits, beyond which it can no longer go to improve image quality. The computational speed of modern processors is already so high that it can quickly convert all signals gathered by the head without any problems. However, a further increase in the frequency of the ultrasound emitted by the head, increases the amount of detail that can be visualized, but reduces the depth of penetration where you can get a picture. The higher the ultrasound frequency the more they are absorbed by the body and in such cases, the organs located inside the tissues cease to be visible. Tissue Harmonic Imaging THI The phenomenon of the generation of harmonic waves was originally observed in optics in the course of an experiment with a ruby laser, whose light passed through a quartz crystal. After passing through the crystal, in addition to receiving the light at the fundamental frequency, the light was also received at twice the frequency compared to the light of the fundamental frequency emitted by the laser [4]. The formation of a wave having twice the frequency the second harmonic is associated with the effects of nonlinear wave propagation in the medium. In the case of ultrasound, it is related to the vibration of tissue [5 7]. As in the case of optics, so the acoustic wave can generate harmonics of higher orders. However, due to the decrease in the intensity of successive harmonics, in practice it is most common to do imaging using the second harmonic. The advantage of harmonic imaging is the ability to use the heads, which emit ultrasound of relatively low-frequency sounds in relation to the ultrasound which go back to the head and which are used to obtain the image. A head emitting a frequency of 5 MHz ultrasound will record the vibrations with a frequency of 10 MHz, so the amount of detail and resolution of the resulting image will be much greater than would result from the frequency of the head itself. Harmonic Imaging requires a special kind of head. It must be additionally equipped with a filter that will remove the fundamental frequency waves which return as a result of reflection from the tissue. Otherwise, the second harmonic signal would be almost completely overshadowed by the fundamental frequency.

5 Modern Ultrasonography 783 Fig. 5. Longitudinal section through the knee joint. Image on the left was obtained using traditional ultrasonography. Image on the right was obtained using sulphur hexafluoride intravenous contrast medium Ryc. 5. Przekrój podłużny stawu kolanowego. Obraz po lewej uzyskano podczas standardowego badania USG. Obraz po prawej stronie został uzyskany z użyciem dożylnego środka kontrastowego (fluorku siarki-6) A harmonic wave of lower intensity also allows you to get a significantly cleaner image especially in the case of imaging structures such as cysts. In the case of harmonic imaging, there is a reduction of artifacts due to the fact that the second harmonic has a much smaller echo than the wave generated by the head. SRI/XVIEW At the beginning of this article the authors mentioned that one of the most obvious ways of improving the quality of imaging is to increase the computing power of processors used for analyzing the recorded signal. Processors installed in the latest ultrasonographic machines actually already have the computing power to fully cover the needs of signal analysis. Its power is large enough to be used for additional analysis without sacrificing the speed of the projecting image. One possible application of high performance computing is a digital analysis of the processed signal before it is displayed on the monitor. This option is the SRI or XView the name changes depending on the manufacturer of the ultrasonographic machine. However, the basic algorithm of this method is the same. During the study, one of the most common causes of poor image quality was a very high amount of noise that hampers giving an accurate diagnosis during the study. This can be seen by both too little contrast between structures in the studied tissue and small amounts of detail shown. Initially, the pixels of the image of which it is built are segregated into two groups the pixels showing the tissue, and pixels which are noise. Inclusion of a pixel into one of these two groups is based on an analysis of the pixels that lie directly in its environment. Evaluation is done on a determination of the pixel gray level in comparison to neighboring pixels. If the shades vary randomly, the pixel is added to the noise group. Conversely, if the transition is smooth, then the pixel is counted as a structural element of the test tissue. In the case that the pixel is classified as noise, the algorithm adjusts its tint to the surrounding pixels. Conversely, if the pixel at the beginning has been classified as part of the tissue, the algorithm for analyzing the remaining pixels in the surrounding area is trying to keep this trend [7, 8]. Thanks to this algorithm, the sharp edges of structures are depicted, which in the absence of such analysis is difficult to obtain due to the scattering of the ultrasound at the borders of structures.

6 784 CrossXBeam CRI This option is an attempt to improve the quality of imaging from a different side than in the case of the previously-discussed techniques. In both of these cases, one of the advantages was to remove noise once by reducing the signal strength and increasing the frequency wavelength registered by the head, and the second time by digital image analysis. In the case study using the CRI option, ultrasound beams are emitted at different angles from the head. The appearance of noise and artifacts will vary depending on the angle of the ultrasound beam. The image is formed on the basis of a signal from multiple beams even 11 beams can be used in this technique nowadays. Improvement in the picture quality is achieved by a clearer distinction between the tissues in this study, and greater visibility of the edges contained in these structures. In addition, this option can be flawlessly combined with harmonic imaging and the noise reduction option SRI. Contrast Agents The use of contrast has long been common in imaging studies even in studies with such very high image quality as computed tomography or magnetic resonance imaging. For many reasons, among others because of the manner of obtaining the image and the availability of ultrasound, contrast agents used in ultrasound must be completely different than the specificity of contrast agents used for example in computer tomography and magnetic resonance imaging. The development of contrast agents proceeded quite differently and for a long time they did not have great use in ultrasonography. This was mainly due to the short duration of the maintenance of the contrast agents in the bloodstream which did not allow for accurate performance testing. Only second-generation contrast agents made it possible to carry out a thorough ultrasound examination [7, 9]. Compared to the first contrast agents, which were nothing more than gas bubbles, the second-generation contrast agents are the product of advanced chemistry laboratories. The gas bubbles that were used during the 60s of the twentieth century have been replaced by phospholipid membranes, with the gas placed S. Jeka et al. inside these membranes. Such a structure of bubbles, whose dimensions are about 3 microns, significantly improves their stability. They are much more resistant to environmental factors, like changes in pressure in the circulatory system. This has resulted in an increase in the time you can do the test with their use to several minutes. There is no longer insufficient time to perform a thorough ultrasound examination including an assessment of blood flow within the synovial membrane, which, as already mentioned at the beginning, is often in the early stages of development of rheumatic diseases [10]. The resistance of the new generation of contrast agents to mechanical damage, as a result of pressure changes caused by the passage of ultrasound or a change in blood pressure, also allows for wider use of them. When properly selected, ultrasonic frequencies emitted by the head can have non-linear oscillations (vibrations) forced on them, which causes them to become a source of the second harmonic wave which we mentioned earlier. This allows for even better picture quality. Conclusions The development of ultrasound techniques have certainly contributed to the growth of applications of this type of research in different fields of medicine. This implies, however, the need for the continuous upgrading of knowledge by the doctors performing the tests, in order to use the options that are best for the type of test. Even harmonic imaging is a very good option for imaging of superficial structures, parts of organs such as the nipples, testicles, salivary glands or thyroid. However, it is no longer the best choice for deep-lying organs such as kidneys, spleen and bladder. The high availability of ultrasonographic examination and the fact that it is much safer than other imaging studies, even with the contrast agents, is another advantage. Unfortunately, the development of techniques and improvement of the quality of ultrasound imaging does not always go hand in hand with the establishment of accurate diagnostic criteria of diseases, as is the case even in the case of rheumatology although training provided by both the British Society of Rheumatology, EULAR and ACR may, in the future, lead to changes in such state of affairs [11].

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