Li-Fraumeni syndrome is a rare genetic disorder, which conveys a great increase in the risk of developing cancer. Cancers associated with Li-Fraumeni syndrome include breast cancer, osteosarcoma, sarcoma, brain tumors, leukemia, adrenocortical carcinoma, and other. A very similar condition called Li-Fraumeni-like syndrome shares many features of classic Li-Fraumeni syndrome. Both conditions convey significantly increased risk of developing multiple cancers beginning from childhood. The pattern of cancers seen in affected family members is different.