If you are downloading the 12.2.1 update, then you are downloading the wrong thing. That is not an update for After Effects CS6. The page that you link to says that the most recent update for After Effects CS6 is the 11.0.4 update. Use that.

Unfortunately, I got the same error message... I attached some screen shots to give you an idea of what it looks like from my end. Do I have to update to 11.0.1, 11.0.2, and 11.0.3 before going straight to 11.0.4?

Do I have to update to 11.0.1, 11.0.2, and 11.0.3 before going straight to 11.0.4?

You shouldn't have to.

There were a few people who experienced issues installing the updates to Mavericks too. You might check for some of those threads to see their solutions. The first thing I would look at is making sure your permissions are set correctly. Often, when updating Mac OSX, they're not set right.

By the way, manually downloading and installing update packages is not the best way to install updates. Read the introductory paragraphs here, in which it tells you to use the Help > Updates command from any Adobe application to update all of them:

How can I get passed this error? I tried reinstalling but had no luck. I put a phone call in to customer service but there is no tech support available for this product. The website says to contact this form, but this has not been helpful either. I am extremely frustrated at the lack of customer service from Adobe and will think twice about buying products from.