This latest version of Shadowrun is fairly streamlined, and as always, I love the setting.
The rules for each activity (magic, tech, combat) work under fairly similar logic, which makes playing faster and easier.
I like how the Matrix has become even more pervasive and integrated into daily life.

The point buy is very flexible, and creates reasonably competent characters, though it is very tempting to minmax.

The illustrations are color and very pretty, and I like the short stories before each chapter.

This may be a problem with PDFs in general, but I find that the pages lag terribly when trying to flip through the book. Not too bad once you can remember where everything is, but still annoying.
As part of the revision from 4th Edition, a lot of the page references have changed, and several of them are off by a page or two.