Eyes

Homocysteine auto-oxidizes and reacts with reactive oxygen intermediates, damaging endothelial cells and increasing the risk of thrombus formation. [14] [15] Ectopialentis [ edit ] Homocystinuria is the second most common cause of heritable ectopialentis[en.wikipedia.org]

Psychiatrical

An additive antioxidant action of 5-MTHF has been suggested to ameliorate endothelial dysfunction through increased nitric oxide production and superoxide radical scavenging, independent of Hcy lowering.[insights.ovid.com]

Cardiovascular risks [ edit ] Elevated homocysteine is a known risk factor for cardiovascular disease as well as thrombosis. [5] It has also been shown to be associated with microalbuminuria which is a strong indicator of the risk of future cardiovascular[en.wikipedia.org]

Treatment

In conclusion, high-dose 5-MTHF treatment for 3 months ensures marked Hcy lowering to normal values even in subjects with high Hcy levels, and should be the treatment of choice in medium hyperhomocysteinemia.[insights.ovid.com]

Prevention

[…] endothelial nitric oxide synthase, as increased endothelial lipid peroxidation and oxidation of the redox-sensitve dye 2,7-dichlorofluoresceine could only be observed after incubation of endothelial cells with L-, but not with D-homocysteine, and could be prevented[eurekaselect.com]