The protein encoded by GRIN1 is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. Additionally we are shipping GRIN1 Antibodies (257) and GRIN1 Proteins (10) and many more products for this protein.

Epigenetic changes in GRIN1, in combination with experiences of maltreatment, may confer risk for depression in children.

Reduction in NR1 and NR2C (show GRIN2C ELISA Kits) in the DLPFC of people with schizophrenia may lead to altered NMDAR stoichiometry and provides compelling evidence for an endogenous NMDAR deficit in schizophrenia.

Isolated GluN1/GluN3A (show GRIN3A ELISA Kits) receptors integrated into lipid bilayers responded to addition of either glycine or d-serine, but not glutamate, with a approximately 1 nm reduction in height of the extracellular domain

PIP2 supports the open state of NMDA receptors via the adaptor protein alpha-actinin (show ACTN1 ELISA Kits). PIP2 and alpha-actinin (show ACTN1 ELISA Kits) act like a two-component hinge keeping the channel gate in its open state.

Study demonstrated that NMDAR functions are regulated by ghrelin (show GHRL ELISA Kits) in a GHSR1a-dependent manner: NMDAR-mediated synaptic currents are increased as a result of GluN1 subunit phosphorylation in the hippocampal pyramidal neurons and synapses

Study compared neuronal injury in the hippocampal CA1 (show CA1 ELISA Kits) region to that in PCs and investigated the role of NMDA receptors GluN2B (show GRIN2B ELISA Kits) and GluN1 in Purkinje cell injury in a mouse model of cardiac arrest and cardiopulmonary resuscitation

Results suggest that NMDA-receptor(Grin1)-mediated synaptic plasticity in the dorsal striatum contributes to strategy shifting and that striatal projection neurons of the direct pathway are particularly relevant for this process

GRIN1 Antigen Profile

Antigen Summary

The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described.