Patient has been fully informed and has signed an IRB approved informed consent form and is willing and able to follow study procedures

Patient is a primary liver transplant recipient

Patient must receive first dose of XL or Prograf (or IV tacrolimus for subjects unable to tolerate oral study drug) within 48 hours of transplantation

Female patients of child bearing potential must have a negative urine or serum pregnancy test within 7 days prior to transplant

Exclusion Criteria:

Patient has previously received or is receiving an organ transplant other than a liver

Recipient or donor is known to be seropositive for human immunodeficiency virus (HIV)

Patient has received a liver transplant from a non-heart beating donor

Patient has received an ABO incompatible donor liver

Patient has a current malignancy or a history of malignancy (within the past 5 years), except hepatocellular carcinoma within UCSF Criteria 21 and basal or non-metastatic squamous cell carcinoma of skin that has been treated successfully

Patient has fulminant hepatic failure, unless hemodynamically stable

Patient has an uncontrolled concomitant infection, a systemic infection requiring treatment (except viral hepatitis), or any other unstable medical condition that could interfere with the study objectives

Patient has severe diarrhea, vomiting, active peptic ulcer or gastrointestinal disorder that may affect the absorption of tacrolimus

Patient is currently taking or has been taking an investigational drug in the 30 days prior to transplant

Patient has a known hypersensitivity to tacrolimus, mycophenolate mofetil or corticosteroids

Patient is pregnant or lactating

Patient is unlikely to comply with the visits scheduled in the protocol, including the protocol biopsies

Patient has any form of substance abuse, psychiatric disorder or a condition that, in the opinion of the investigator, may invalidate communication with the investigator

Gender

Both

Ages

18 Years to 70 Years

Accepts Healthy Volunteers

No

Contacts ICMJE

Contact information is only displayed when the study is recruiting subjects