Side Effects

DUZALLO can cause serious side effects, including:

Kidney problems:
Some people taking DUZALLO may have kidney problems such as a sudden decrease
in kidney function (acute kidney failure). Your healthcare provider may do blood
tests to check your kidneys while you are taking DUZALLO.

Serious skin rash and serious allergic reactions:
Severe and potentially life-threatening allergic reactions and skin reactions
including Stevens-Johnson syndrome, toxic epidermal necrolysis and exfoliative
dermatitis have been reported in some people taking allopurinol, one of the components of DUZALLO.
Stop taking DUZALLO and get emergency medical help if you have any of the following symptoms:

skin rash; blistering of the skin, mouth, nose, and genitals

painful red or purple skin that looks burned and peels off

joint pain; swollen glands

red, painful, watery eyes; persistent itching; hives

fever

Liver problems:
Liver problems can happen in people who take DUZALLO.
Call your healthcare provider if you have any of the following symptoms:

loss of appetite

weight loss

feeling very tired

nausea or vomiting

yellowing of your skin or the white part of your eyes

itching

dark or brown (tea-colored) urine

pain on the upper right side of your stomach

Heart problems:
People who take DUZALLO can have serious heart problems including
heart attack and stroke. It is not known that DUZALLO causes these problems.

Blood problems:
DUZALLO can affect your bone marrow and cause low red blood cells,
white blood cells and platelets. If your blood cell counts become very low,
you can get infections or have bleeding problems. Taking DUZALLO
with certain other medicines can increase your chance of having blood problems.

The most common side effects of DUZALLO include:

headache

flu

higher levels of blood creatinine (a measure of kidney function)

heartburn (acid reflux)

skin rash

nausea

diarrhea

These are not all of the possible side effects of DUZALLO.
For more information, talk to your healthcare provider.

Always tell your doctor about any side effects you experience.
For more information about DUZALLO, see the
Medication Guide.

Important Safety Information

DUZALLO can cause serious side effects.

Kidney problems: Some people taking DUZALLO may have kidney problems such as a sudden decrease in kidney function (acute kidney failure). Your healthcare provider may do blood tests to check your kidneys while you are taking DUZALLO.

Serious skin rash and serious allergic reactions: Severe and potentially life-threatening allergic reactions and skin reactions including Stevens-Johnson syndrome, toxic epidermal necrolysis and exfoliative dermatitis have been reported in some people taking allopurinol, one of the components of DUZALLO. Stop taking DUZALLO and get emergency medical help if you have any of the following symptoms:

skin rash; blistering of the skin, mouth, nose, and genitals

painful red or purple skin that looks burned and peels off

joint pain; swollen glands

red, painful, watery eyes; persistent itching; hives

fever

Liver Problems: Liver problems can happen in people who take DUZALLO. Call your healthcare provider if you have any of the following symptoms: loss of appetite, weight loss, feeling very tired, nausea or vomiting, yellowing of your skin or the white part of your eyes, itching, dark or brown (tea-colored) urine, or pain on the upper right side of your stomach.

Heart Problems: People who take DUZALLO can have serious heart problems including heart attack and stroke. It is not known that DUZALLO causes these problems.

Blood Problems: DUZALLO can affect your bone marrow and cause low red blood cells, white blood cells and platelets. If your blood cell counts become very low, you can get infections or have bleeding problems. Taking DUZALLO with certain other medicines can increase your chance of having blood problems.

Drowsiness: DUZALLO can cause you to be drowsy. Do not drive, operate heavy machinery, or do other dangerous activities until you know how DUZALLO affects you.

The most common side effects of DUZALLO include headache, flu, higher levels of blood creatinine (a measure of kidney function), heartburn (acid reflux), skin rash, nausea, and diarrhea. Tell your healthcare provider if you have any side effect that bothers you or that does not go away. These are not all of the possible side effects of DUZALLO. For more information, ask your healthcare provider or pharmacist.

What is DUZALLO?

DUZALLO is a prescription medicine that contains 2 medicines, a URAT1 inhibitor called lesinurad and a xanthine oxidase inhibitor called allopurinol. DUZALLO is used to lower uric acid levels in the blood in people with gout, when allopurinol alone has not worked well enough.

Ironwood® and the three-leaf design are registered trademarks of Ironwood Pharmaceuticals, Inc. DUZALLO® and its logo are registered trademarks of AstraZeneca or its affiliates and are used herein under license.

Important Safety Information

DUZALLO can cause serious side effects.

Kidney problems: Some people taking DUZALLO may have kidney problems such as a sudden decrease in kidney function (acute kidney failure). Your healthcare provider may do blood tests to check your kidneys while you are taking DUZALLO.