GREMLIN Results:
Residue pairs sorted by strength in covariance:Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

i

j

Raw Score

Scaled Score

88_D

91_E

0.38924

3.490

3_Y

86_P

0.29068

2.606

29_V

97_K

0.22657

2.031

86_P

92_F

0.21926

1.966

22_P

25_E

0.21796

1.954

7_D

23_L

0.19758

1.772

9_G

20_T

0.19556

1.753

73_I

92_F

0.17535

1.572

10_L

23_L

0.16815

1.508

5_V

23_L

0.159

1.426

62_V

83_V

0.15433

1.384

49_Y

85_S

0.1537

1.378

3_Y

92_F

0.15204

1.363

73_I

93_I

0.15034

1.348

27_E

78_K

0.14625

1.311

11_I

73_I

0.14177

1.271

14_W

17_G

0.14171

1.271

77_T

82_Y

0.13889

1.245

40_R

43_G

0.13872

1.244

9_G

23_L

0.13864

1.243

31_L

93_I

0.13779

1.235

68_R

85_S

0.1365

1.224

10_L

20_T

0.136

1.219

32_V

74_L

0.13425

1.204

74_L

83_V

0.131

1.175

31_L

84_I

0.12944

1.161

73_I

89_P

0.12878

1.155

6_D

11_I

0.12662

1.135

39_I

87_E

0.1258

1.128

21_I

82_Y

0.12541

1.124

46_G

49_Y

0.12266

1.100

85_S

92_F

0.12231

1.097

42_F

46_G

0.1214

1.089

10_L

22_P

0.12009

1.077

12_I

21_I

0.11901

1.067

16_F

43_G

0.11783

1.056

67_T

92_F

0.11598

1.040

34_D

72_V

0.1149

1.030

5_V

10_L

0.11308

1.014

9_G

22_P

0.11279

1.011

49_Y

65_Y

0.11239

1.008

28_S

34_D

0.11232

1.007

72_V

85_S

0.11232

1.007

75_I

80_K

0.11106

0.996

6_D

9_G

0.10954

0.982

66_A

85_S

0.10889

0.976

91_E

95_A

0.10878

0.975

56_N

62_V

0.10714

0.961

12_I

94_E

0.10679

0.958

20_T

90_E

0.1064

0.954

8_D

23_L

0.10584

0.949

34_D

64_L

0.10513

0.943

29_V

84_I

0.10491

0.941

54_F

84_I

0.10445

0.937

11_I

18_K

0.10405

0.933

56_N

73_I

0.10393

0.932

28_S

76_K

0.1022

0.916

43_G

66_A

0.10198

0.914

78_K

95_A

0.10158

0.911

76_K

81_T

0.10111

0.907

41_T

45_G

0.10089

0.905

21_I

88_D

0.09915

0.889

58_G

79_D

0.0988

0.886

64_L

72_V

0.0986

0.884

42_F

72_V

0.09811

0.880

10_L

76_K

0.0981

0.880

5_V

92_F

0.09809

0.880

69_N

85_S

0.09779

0.877

31_L

97_K

0.09749

0.874

87_E

91_E

0.09742

0.873

20_T

27_E

0.09683

0.868

12_I

15_P

0.09672

0.867

66_A

86_P

0.0965

0.865

25_E

78_K

0.09558

0.857

53_R

56_N

0.09556

0.857

30_E

90_E

0.09551

0.856

83_V

86_P

0.0951

0.853

12_I

67_T

0.0942

0.845

91_E

94_E

0.09349

0.838

44_S

53_R

0.09293

0.833

14_W

80_K

0.09291

0.833

93_I

97_K

0.09272

0.831

19_I

22_P

0.09268

0.831

70_K

88_D

0.09268

0.831

12_I

24_A

0.09233

0.828

11_I

20_T

0.09208

0.826

71_N

89_P

0.09149

0.820

67_T

86_P

0.09076

0.814

6_D

18_K

0.09061

0.812

73_I

78_K

0.09039

0.810

26_I

72_V

0.08951

0.803

66_A

69_N

0.08742

0.784

30_E

76_K

0.08723

0.782

92_F

96_L

0.08706

0.781

26_I

31_L

0.08667

0.777

92_F

95_A

0.08652

0.776

24_A

55_R

0.08644

0.775

26_I

29_V

0.08589

0.770

34_D

83_V

0.08573

0.769

45_G

64_L

0.08571

0.769

14_W

69_N

0.08557

0.767

35_L

72_V

0.08556

0.767

4_E

18_K

0.08535

0.765

74_L

81_T

0.08531

0.765

14_W

47_F

0.08512

0.763

45_G

60_G

0.08512

0.763

5_V

33_D

0.08474

0.760

43_G

65_Y

0.08472

0.760

41_T

92_F

0.08468

0.759

53_R

80_K

0.08466

0.759

47_F

62_V

0.08462

0.759

41_T

61_K

0.0844

0.757

10_L

96_L

0.08431

0.756

29_V

92_F

0.08429

0.756

25_E

58_G

0.0842

0.755

28_S

90_E

0.08406

0.754

42_F

53_R

0.0839

0.752

41_T

47_F

0.08388

0.752

12_I

25_E

0.08363

0.750

17_G

66_A

0.08344

0.748

56_N

61_K

0.08342

0.748

6_D

82_Y

0.08329

0.747

23_L

29_V

0.08298

0.744

24_A

61_K

0.08294

0.744

14_W

42_F

0.08293

0.744

70_K

94_E

0.08269

0.741

14_W

49_Y

0.08222

0.737

93_I

96_L

0.08184

0.734

45_G

59_Y

0.08178

0.733

94_E

97_K

0.08156

0.731

78_K

90_E

0.08146

0.730

21_I

77_T

0.08125

0.729

Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.

HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits: Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)