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One person died and three individuals were injured Tuesday evening after a vehicle apparently drove off the side of the 405 Freeway in Van Nuys, landing in a homeless encampment, officials said.

Investigators evaluate the aftermath of a crash that left at least one person dead and another two critically injured. (Credit: KTLA)

Firefighters responded to the incident as a rescue around 6:14 p.m. near the offramp at Sherman Way, according to the Los Angeles Fire Department. The car drove off an embankment on the right shoulder around 6:06 p.m. and landed on Strathern Street, according to the California Highway Patrol.

One person was pronounced dead at the scene due to injuries sustained in the massive crash, and another two were transported in serious to critical condition, officials said.

A car crashed off the side of the 405 Freeway on Nov. 29, 2016, falling on top of a homeless encampment. (Credit: KTLA)

The driver of the vehicle was transported in fair condition with injuries that were not life-threatening, according to the fire department.

Firefighters had to rescue two victims from underneath the vehicle, according to LAFD Battalion 10 Chief Kristina Kepner. Despite the complicated rescue conditions, the first patient was taken to the hospital within 15 minutes of first responders’ arrival, she added.

The ages and genders of those struck were unknown, Kepner said.

Both the right-hand lane of the 405 Freeway and Strathern Street were closed in the evening but later reopened.