Fogarty International Center (FIC)
National Institute of Allergy and Infectious Diseases (NIAID)Eunice Kennedy Shriver National Institute of Child
Health and Human Development (NICHD)
National Institute of Mental Health (NIMH)

Purpose

Given the increasing recognition of women as fundamental to
the health of populations, the Fogarty International Center (FIC), with National Institute of Allergy and
Infectious Diseases (NIAID),

Eunice Kennedy Shriver National Institute of Child Health
and Human Development (NICHD), and
National Institute of Mental Health (NIMH),
is soliciting applications for one-year administrative supplements to active
NIH international research or research training grants for the purpose of
developing research applications for implementation science intended to
accelerate progress towards improved health for women and girls and/or the role
of women and girls in the improvement of health. These supplements are
intended to be used for planning for future grant applications either to other
NIH institutes, to other U.S. Government (USG) agencies, particularly those
engaged in the Global Health Initiative (GHI), or to outside international
research funding entities.

Over the long term, the health of women enhances their
productivity, their social and economic participation, and also acts as a
positive multiplier, benefitting social and economic development through the
health of future generations. The ability of women to access health-related
knowledge and services is fundamental to the health of their families. However,
both because of their reproductive role and patterns of gender discrimination,
girls and women are particu­larly vulnerable to ill health, and are
comparatively underserved by health services.

One of the USG initiatives currently focusing on issues
related to the health of women and girls is the GHI. The GHI is an
evidence-based, health outcome-driven, whole-of-government approach to global
health. The GHI aims to help partner countries improve health outcomes through
strengthened health systems and is guided by a set of seven principles. The
core principles of the GHI are:

To focus on women, girls, and gender quality;

To encourage country ownership;

Build sustainability through health systems strengthening;

Increase impact through strategic coordination and integration;

Improve metrics, monitoring, and evaluation;

Promote research and innovation.

The NIH proposes to issue these administrative supplements
to active NIH international research or research training grants during FY 2011
to stimulate applications for research that will enhance the evidence base for
translating effective interventions into community and population-level
programs, services, and strategies at scale. Research applications should
encompass as many of the Global Health
Initiative's (GHI) principles as possible with particular focus on the
principles of women and girls, gender equality, and host country leadership.

More specifically, the intent of these supplements is:

To provide an opportunity to make an important contribution to
better health for women and girls through applications for targeted
implementation research on knowledge gaps in advancing women and girls’ health;

To foster host country leadership in research; and

To stimulate or expand coordination and integration of research
with existing and/or planned health programming, particularly those that are
supported by the USG, and where appropriate, with emphasis on those that
advance country-specific GHI targets.

SPECIFIC RESEARCH AREAS

The proposed research should advance the health of women and
girls, be host-country driven, sufficiently oriented toward implementation
science, and encompass as many of the GHI principles as possible.

Cost-effective, novel, innovative research methodologies for
demonstration of the effectiveness of programs that are increased to scale are
encouraged.

Applications for HIV/AIDS related research will not be
accepted under this solicitation. HIV/AIDS related grants are not eligible
either even if the research proposed is non HIV/AIDS related.

Where appropriate, the proposed research should synergize
with GHI country plans and/or national research priorities or advance the work
of the GHI within country through attention to GHI principles. To facilitate
this, as part of the supplement application, grantees are strongly encouraged
to include a strategy for engagement with the in-country USG team as part of
the planning process for proposed research. This strategy might include a
letter from the US Country Health team stating that the research would be
valuable for USG and country programming to facilitate the evidence base for
country policy and programming.

Potential applicants are strongly encouraged to contact the NIH Point of Contact from the IC administering the parent grant prior to submitting applications to
clarify appropriateness of the supplement for their grant.

Clarifications of any questions regarding agency priorities,
and how these may fit with their currently funded research, can be discussed at
that time.

Budget and Funding Information

Funding will be available for fiscal year FY 2011 for
administrative supplements to currently funded NIH research and research
training grants. Supplement requests must be for not more than $40,000 in
direct costs for a funding period of one year. In addition, the budget format
should be the same as that used for the parent grant i.e. modular or detailed.

The majority of the work done under the supplement must be
conducted with leadership from host-country researchers and institutions, and
thus, 80% of the award dollars should be spent in the foreign country, and the
resulting research applicationl should be led by a host-country researcher or
researchers.

While there are no pre-designated follow-on funding
announcements, the supplements are intended to result in applications for
research ranging from approximately $50,000 to $300,000/year (direct costs) for
3 years or appropriate for the NIH unsolicited R01 pool.

Eligibility

This announcement is for administrative supplements for
funded R01, R21, D43, U19 (NIMH-specific), and T32 (NIAID-specific) grants will
be allowed.

Applicants are limited to investigators with current NIH
grant funding for research or research training from the co-sponsoring
institutions.

Applicants eligible for this supplement must already have a
strong existing relationship with a foreign academic institution or
organization as demonstrated by the geographic focus of the current NIH grant.

The proposed supplement must be within the general scope of
the peer-reviewed activities and aims approved within the parent grant.

A letter of support must be provided by the authorized
organizational official for each collaborating institution.

Grants in their last year of funding or in no cost
extensions categories are not eligible for this opportunity.

For applications oriented towards the GHI, priority will be
given to applications from GHI program countries. The list of these countries
can be found in the FAQ section of the supplement website.

To be eligible, the parent grant must be active, and the research proposed in the supplement
must be accomplished within the competitive segment. The proposed supplement
must be within the general scope of the peer-reviewed activities and aims
approved within the parent grant.

IMPORTANT: The research proposed by the NIH grantee in the supplement
application must be within the original scope of the NIH-supported grant
project. The funding mechanism being used to support this program,
administrative supplements, can be used to cover cost increases that are
associated with achieving certain new research objectives as long as they are
within the original scope of the project. Any cost increases need to result
from making modifications to the project in order to take advantage of
opportunities that would increase the value of the project consistent with its
originally approved objectives and purposes.

Submitting an Administrative Supplement Request

To be considered for an administrative supplement, the
request must be signed by the Authorized Organizational Representative/Signing
Official (AOR/SO), and must describe the need for additional funding and the
categorical costs.

Submit one original, hard copy of the request packet (with original signatures
of the authorized business official) to the address listed below:

In addition, applicants are encouraged to send an electronic
copy of the submitted supplement request as an e-mail attachment in PDF format
to the email listed above.

Requests should be submitted on the PHS398
Application Guide forms (font size and other formatting rules apply as
designated in the instructions), as indicated below. Include only the following
elements:

Cover
Letter which cites this Notice, and the following information:

Project Director/Principal Investigator (PD/PI) name

Parent grant number and title

Amount of the requested supplement

Name and title of the institutional official, and

Phone, email, and address information for both the PD/PI and
institutional official.

The cover letter must be signed by the authorized organizational
representative/institutional official.

PHS
398 Form Page 1 (Face page)

The title of the project should be the title of the parent award.

This Notice should be cited in Box 2, and the “yes” box should be
checked.

The Principal Investigator (PI) must be the same as the PI on the
parent award. For Multiple PI parent awards, the Contact PI must be the
PI listed on the supplement request, and the supplement cannot change the
Multiple PI team.

The remaining items on the face page should be filled out in
accordance with the PHS 398 application instructions.

PHS
398 Form Page 2

Note: The project “summary” is that of the administrative
supplement, not the parent grant.

A
brief proposal describing the project, including:

Scope of the overall project and the anticipated contribution of
the requested supplement (not to exceed five pages).

Provide a brief description of the scope of the overall project
on which the supplemental request is based.

This section should include a description of the supplement's
specific aims, including research design and methods and data analysis.
Describe the relationship of the supplement request to the parent grant.

Budget for the supplement with a justification that details the
items requested, including Facilities and Administrative costs.

Biographical Sketch for all new key personnel(those who
are additions on the supplemental project

Human Subjects/ Vertebrate Animal documentation (if applicable).

Include a current Human Subjects/IRB or Vertebrate Animals/IACUC
approval letter, if available. Otherwise, this will be required at the time of
funding. All appropriate IRB and IACUC approvals must be in place prior to a
supplement award being made.

Any differences in the involvement or use of human subjects or
specimens, or use of vertebrate animals, between the administrative supplement
activity and the parent grant should be noted.

When appropriate, details should be provided on the protection of
human subjects and inclusion of women, children, and minorities.
Additional guidance on Human Subjects Research and Vertebrate Animals is
provided under Part II of the PHS 398 instructions.

PHS 398 Checklist Form

Selection

Administrative supplement applications in response to this
funding opportunity will compete for available funds with all other recommended
applications. The following will be considered in making funding decisions:

Relevance of the proposed activities to the NIH parent grant
activities or geographic location

Scientific content for program balance.

Geographic balance considerations.

Relevance to the interests of partner organizations.

Inquiries

Inquiries and discussion of plans for responding to this
Notice are strongly encouraged.