Doctor insights on:
Sometimes When I Wake Up My Hands Have A Very Strong Itch What Might This Be

1

Rash?:
Without any sign of a rashsevere itching limited to the palms after sleep is unusual. Systemic meds could have it chi g as a side effect although localized itching to the palms is unusual. Try cold compresses in am and oral antihistamine at night before going to sleep.
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2

See doctor:
If these have been present for less than a week or so, it is ok to use Hydrocortisone cream. But if it is getting worse or lasting longer than that, you will need to see your doctor to get the area examined. If the blisters are oozing, you need to see your doctor immediately. Since you stated my hands, I presume they involve both sides.
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7

Many possibilities:
There are many things that could cause the skin to itch. Several types of inflammatory conditions of the skin, allergic reactions, sun exposure, insect bites, and sometimes bacterial, viral or fungal infections can cause rashes on the skin. Have it evaluated by a professional and get the appropriate treatment.
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