Weitere Antikörper gegen EIF3L Interaktionspartner

These results indicate an interaction of human eIF3L with yellow fever virus NS5 (zeige RAF1 Antikörper) and that eIF3L overexpression facilitates translation, which has potential implications for virus replication.

EIF3L Antigen-Profil

Beschreibung des Gens

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of posttermination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (By similarity).