New developments and future plans in the macromolecular refinement program - REFMAC

Refmac is a macromolecular refinement program that uses some aspects
of the Bayesian statistics and the maximum likelihood techniques. Refmac
has
an extensive built in dictionary of macromolecular building blocks.
These include amino acids, DNA/RNA, sugars and many others. There are
also
tools available to create new dictionary entries. This talk will
concentrate
around the description of the dictionary, some of its features and tools
available to handle new ligands. Some of the latest developments
including
Fisher's information matrix, refinement against data sets from twinned
crystals and some future plans will also be highlighted.