The use of glycerol as renewable raw material is limited so far to its employment in cosmetics, food and luxuries as well as plastics. However, the output exceeds clearly the need of glycerol due to his formation as by-product in biodiesel production. The industrial production of secondary products would be highly desirable particularly since chemicals from petrochemical raw materials can be replaced. In particular the oxidation of the secondary alcohol function examined in this work can make the production of the product dihydroxyacetone economically more attractive. Dihydroxyacetone is not only interesting as active component in cosmetics, but the selective oxidation of glycerol still represents a scientific challenge. The problems of this reaction derive from deactivation of the catalyst, which leads to a reduction in selectivity to dihydroxyacetone with reaction progress. It could be stated by investigation of catalyst deactivation and kinetic modelling that particularly the strong adsorption of by-products onto the catalyst contributes to catalyst deactivation. A kinetic model with consideration of two active centers was set up, on whose basis a dihydroxyacetone yield of 70 % is forecast, if removing by-products from the reaction mixture is successful. By the use of membrane separation processes by-products were removed nearly quantitatively. The activity increased and the reduction of the selectivity to dihydroxyaceton could be mildered. By performing the reaction in a continuously working trickle bed reactor dihydroxyacetone yields from up to 60 % could be received, however further deactivation processes lead to a reduction of the yield.