C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring

C07C43/215—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring having unsaturation outside the six-membered aromatic rings

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS

C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds

C07C45/44—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reduction and hydrolysis of nitriles

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS

C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds

C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups

C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton

C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms

Abstract

Translated from German

Es werden Diarylacetylene der Formel II There are diarylacetylenes of the formula II

beschrieben, in der A und R 1 -R 6 die in der Beschreibung angegebene Bedeutung besitzen. described, in which A and R 1 -R 6 have the meaning given in the description.Die neuen Verbindungen eignene sich zur Bekämpfung von Krankheiten. The new compounds some own for combating diseases.

9. Verfahren zur Herstellung der Diarylacetylene der Formel I gemäß Anspruch 1, dadurch gekennzeichnet, daß man 9. A process for the preparation of the diarylacetylenes of formula I according to claim 1, characterized in that

in Gegenwart eines Katalysators, und einer Base umsetzt in the presence of a catalyst and a baseund die so erhaltenen Verbindungen gegebenenfalls nach Standardmethoden in weitere Verbindungen der Formel I umwandelt. and the compounds thus obtained is optionally converted by standard methods into other compounds of formula I.

10. Verwendung der Arylacetylene der Formel I gemäß Anspruch 1 zur Verwendung bei der Bekämpfung von Krankheiten. 10. Use of the aryl acetylenes of the formula I according to claim 1 for use in combating diseases.

1. Verfahren zur Herstelluna der Diarvlacetylene der Formel I 1. Method for the Production of Diarvlacetylene of the formula I

in Gegenwart eines Katalysators, und einer Base umsetzt und die so erhaltenen Verbindungen gegebenenfalls nach Standardmethoden in weitere Verbindungen der Formel I umwandelt. in the presence of a catalyst and a base, and the compounds thus obtained is optionally converted by standard methods into other compounds of formula I.

Acetylenes disubstituted with a phenyl or heteroaryl group and a 2-thio-1,2,3,4-tetrahdroquinolinyl, 2-alkylthio-3,4-dihydroquinolinyl or 2-alkoxy-3,4-dihydroquinolinyl group having retinoid-like biological activity

Aryl or heteroaryl amides of tetrahydronaphthalene, chroman, thiochroman and 1,2,3,4,-tetrahydroquinoline carboxylic acids, having an electron withdrawing substituent in the aromatic or heteroaromatic moiety, having retinoid-like biological activity

Acetylenes disubstituted with a phenyl or heteroaryl group and a 2-thio-1,2,3,4-tetrahdroquinolinyl, 2-alkylthio-3,4-dihydroquinolinyl or 2-alkoxy-3,4-dihydroquinolinyl group having retinoid-like biological activity

Aryl or heteroaryl amides of tetrahydronaphthalene, chroman, thiochroman and 1,2,3,4,-tetrahydroquinoline carboxylic acids, having an electron withdrawing substituent in the aromatic or heteroaromatic moiety, having retinoid-like biological activity