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Chosen answer:I'm guessing you're referring to the episode "Trapped in the Closet" (ep. 9-12). While it is true that Jillette had a part in the decision to make the episode, Matt Stone and Trey Parker had parodied scientology before, and had been thinking of doing a full episode for some time. Jillette only convinced them to stand up for what they believed in, which is poking fun at anything and anyone.

The creators of the show, Matt Stone and Trey Parker, based the Stan Marsh and Kyle Brosfloski characters after themselves (Stan being Parker and Kyle being Stone.) The Eric Cartman character was partly based on Archie Bunker.