bDepartment of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213;cCampbell Family Mental Health Research Institute of Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada M6J 1H4;dDepartment of Psychiatry, University of Toronto, Toronto, ON, Canada M5T 1R8;eDepartment of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada M5S 1A8