Tony Brioni is separating the women from the men by opening an additional store at the Four Seasons simply to serve its femmes fatales.

The global retailer, whose suits cost $3,000 and up, has had a store there since the hotel opened at 57 E. 57th St.

Brioni has always carried both men’s and women’s clothing, as it does at its other city shop at 55 E. 52nd St.

But with the departure of the slightly more plebeian Dana Buchman, Brioni moved into 2,500 square feet on the eastern end of the hotel, designed by I.M. Pei and Frank Williams.

“Who knows better than a tenant in place, the business you can do?” asked retail broker Faith Consolo, a vice chairman of Garrick Aug Worldwide who was not involved with the deal.

The space had been shopped by Alan Victor at Lansco with asking rent of $1.2 million a year, or a little more than $400 a square foot, a level comparable to other retail deals in the neighborhood, Consolo said.

The new Brioni Women shop will open in time for the chosen few to spend fistfuls of green for a little something to wear in the Easter Parade.