This gel has made it so that I don't have to take any pain meds for my torn rotator cuff. I used the instructions on antother wed site to glob on the gel then immediately put MSM lotion on DO NOT RUB IN. Just rub around the area and leave set for 20 minutes. It soaks in quite fast. In 2 1/2 weeks My pain is almost all gone and I can lift my arm all the way up while holding it straight out to the side of my body. AMAZING. Will buy more when I can. Heal tissues - muscle, cartilage, tendons and ligaments as well as skin like as in wrinkles.