Highly Efficient Cul-catalyzed N-Arylation of Azaheterocycles with Aryl Iodides Using 1,1,1-Tris(hydroxymethyl)ethane as a Tridentate O-Donor Ligand: A Shorter Route to Toloxatone and Formal Synthesis of Linezolid

An efficient copper-catalyzed N-arylation of azaheterocycles with aryl iodides using 1,1,1-tris(hydroxymethyl)ethane as a tridentates O-donor ligand has been accomplished in good to excellent yields. Moreover, this highly efficient catalyst system has been successfully demonstrated to one-step synthesis of toloxatone and a shorter route to formal synthesis of linezolid in good yields.