Ageing: Is fat a key to longevity?p341 | doi:10.1038/nrm.2017.45Worms with impaired H3K4 trimethylation have an extended lifespan, which is associated with the accumulation of monounsaturated fatty acids in their intestines.PDF

RNA decay: The anti-apoptotic function of ADAR1p343 | doi:10.1038/nrm.2017.51An isoform of the RNA-editing protein ADAR1 is shown to be activated through nuclear export in response to cellular stress and to protect anti-apoptotic mRNAs from Staufen 1-mediated decay.PDF

Mechanisms of diseases: Excessive polyQ tracts curb autophagyp344 | doi:10.1038/nrm.2017.50Expansion of polyglutamine tracts in proteins interferes with the process of autophagy and may contribute to the pathology of neurodegenerative diseases.PDF

The HSP90 chaperone machinery Florian H. Schopf, Maximilian M. Biebl & Johannes Buchnerp345 | doi:10.1038/nrm.2017.20The heat shock protein 90 (HSP90) chaperone machinery is a key regulator of proteostasis. Recent progress has shed light on the interactions of HSP90 with its clients and co-chaperones, and on their functional implications. This opens up new avenues for the development of drugs that target HSP90, which could be valuable for the treatment of cancers and protein-misfolding diseases.Abstract | Full Text | PDF

The mystery of membrane organization: composition, regulation and roles of lipid rafts Erdinc Sezgin, Ilya Levental, Satyajit Mayor & Christian Eggelingp361 | doi:10.1038/nrm.2017.16Lipid rafts are relatively ordered membrane domains that are enriched in cholesterol and saturated lipids, and selectively recruit other lipids and proteins. They are dynamic and heterogeneous in composition and are thus challenging to visualize in vivo. New technologies are providing novel insights into the formation, organization and functions of these membrane domains.Abstract | Full Text | PDF | Supplementary information

Planar cell polarity in development and disease Mitchell T. Butler & John B. Wallingfordp375 | doi:10.1038/nrm.2017.11Planar cell polarity — the asymmetric distribution of proteins in the plane of a cell sheet — dictates the orientation of various subcellular structures and drives collective cell rearrangements. Better understanding of this conserved axis of polarity can shed light on the mechanisms of morphogenetic processes and explain the underlying causes of human birth defects.Abstract | Full Text | PDF | Supplementary information

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