Medical Journal of the Islamic Republic Of Iran http://mjiri.iums.ac.ir
Medical Journal of The Islamic Republic of Iran (MJIRI) - Journal articles for year 1993, Volume 6, Number 4Yektaweb Collection - http://www.yektaweb.comen1993/2/12A CRITICAL APPRAISAL OF HUMAN GROWTH STUDIES IN IRANhttp://mjiri.iums.ac.ir/browse.php?a_id=1481&sid=1&slc_lang=en
Studies of human growth throughout Iran since 1966 have been surveyed
critically. Only 32 papers and 15 research reports on this very crucial issue
have been published or compiled so far, most of them on Tehran and Shiraz,
which is negligible in comparison with American or European and even some
African and Asian studies. Though measurements of height and weight
naturally predominate, arm circumference, head circumference and skinfold
thickness are also extensively documented. People are now heavier and taller
than reported previously. Children in well-off homes everywhere grow faster
than those in poor homes and urban children grow faster than rural children.
The necessity for using local standards covering all age groups for clinical
work in Iran is emphasised and a longitudinal growth study is suggested. A
study of the pattern of growth and its related complex factors would serve as an
invaluable asset in planning and (evaluation of community health service and
health promotion. The paper also provides a comprehensive bibliography of
growth studies in Iran which would be helpful to the interested researchers in
this field.
S.M. TAGHl AYATOLLAHIA RARE CASE OF GASTRIC LIPOMAhttp://mjiri.iums.ac.ir/browse.php?a_id=1480&sid=1&slc_lang=en
A middle age woman was hospitalized for investigation of a mobile filling defect in
the stomach with exacerbation of 3-year gastric symptoms. Gastroscopy revealed a huge
pedunculated polyp. Histologic report of the mass was gastric antral lipoma. Since the patient
refused surgery, cauterization polypectomy was performed without any complication.
HOSSEIN FOROUTANRIGHT VENTRICULAR FATTY INFILTRATION IN MITRAL STENOSIS, A RARE CAUSE OF SURGICAL FAILURE.http://mjiri.iums.ac.ir/browse.php?a_id=1479&sid=1&slc_lang=en
A 47 year-old female died after mitral valve replacement. Post-cardiopulmonary
bypass right ventricle was not able to pump despite good left
ventricular contractility. At microscopic examination, diffuse right ventricular
fatty infiltration was found. We found no previous report of this pathology in
patients with mitral stenosis
F NOOHIMETAGENOUS CARCINOMA OF THE BREAST: SECONDARY DEPOSIT OF PAPILLARY CARCINOMA OF THE THYROlD IN A BREAST WITH PRIMARY DUCTAL CARCINOMAA COlNClDENCEhttp://mjiri.iums.ac.ir/browse.php?a_id=1478&sid=1&slc_lang=en
Papillary carcinoma of the thyroid constitutes 80% of thyroid malignancies
in adults. Females are affected at least twice as often as males. It
metastasizes to distant sites very rarely, but to the cervical nodes quite often.
Occasionally metastatic lymph node enlargement is the sole presenting
feature. t.3.6.7 The tumor is slow growing and sometimes the patient has good
survival even in spite of distant metastases. The following case is a coincidence
of two separate rare diseases, one is metastasis of the thyroid papillary
carcinoma to the breast and the second one is coincidence of this unheard
metastasis with carcinoma of the breast itself. By my knowledge, this is the
first case of its kind being reported.
SA JALALIDISTA N T INFECTIONS CAUSED BY THROMBOPHLEBITIC COMPLICATIONS OF CHOLEST EATOMAhttp://mjiri.iums.ac.ir/browse.php?a_id=1477&sid=1&slc_lang=en
The report of two cases of chest and kidney infections reminds of the
possibility of distant infections caused by thrombophlebitic complications of
cholesteatoma.
Deep neck infection, mediastinitis, pleural empyema, pulmonary abscesses
and hematogenic microabscesses of kidney have been proved by clinical,
radiologic and laboratory examinations in two cholesteatoma patients. The
clinical course of distant infections could be terminated by effective surgical
elimination of contaminated thrombi from sigmoid sinus during a mastoid
surgery.
N MOKHTARIA FAMILIAL CASE OF PEMPHIGUS VULGARIShttp://mjiri.iums.ac.ir/browse.php?a_id=1476&sid=1&slc_lang=en
A family in which two members are affected by pemphigus vulgaris is
presented from Gilan. Up to now only 25 families in which more than one
member was affected have been reported
J GOLCHAITHE PRODUCTION OF MURINE MONOCLONAL ANTIBODIES (MAb) DIRECTED AGAINST HUMAN T- LYMPHOCYTE SUBSETShttp://mjiri.iums.ac.ir/browse.php?a_id=1475&sid=1&slc_lang=en
The production of murine monoclonal antibody (MAb) has not yet been reported
in Iran. The present work describes for the first time the generation of several
murine hybridoma clones secreting MAbs directed against human leukocyte
surface antigens. The secreted antibodies by hybridoma clones have been screened
on different lymphoid and non-lymphoid tissues. Results indicated that of seven
hybridomas, clones 3FII, 3C3 and IF2 showed a strong reactivity for T-cells
purified from thymus and tonsil tissues. Moreover, clones I D4 and 605 which
partially stained thymus tissues were found to be negative on purified B-cells and
monocytic cell line U937. The third group, 4ES and 4F4 hybridoma clones was
expressed weakly on purified T, B-cells and U937 cell line. Further work is needed
to determine the epitopes recognized by these MAbs and a comparison of the data
with those presented at the previous leukocyte antigens workshop.
ABBAS A. GHADERI BUPROPION-INDUCE D CLIMBING THROU GH D -1 AND D-2 DOPAMINE RECEPTOR ACTIVATIONhttp://mjiri.iums.ac.ir/browse.php?a_id=1474&sid=1&slc_lang=en
Intraperitoneal (IP) injection of bupropion (3,6,
amine (4,16 mg kg•') induced dose-dependent climbing in mice. The climbing
response induced by both drugs were decreased in animals pretreated either with
the 0-1 antagonist SCH 233<)0 or the 0-2 antagonist sulpiride. The α-adrenoceptor
blocker phenoxybenzamine decreased the climbing induced by both bupropion
and amphetamine, but the β-adrenergic blocker propranolol and the antimuscarinic
agent atropine had no effect. Reserpine pretreatment abolished the climbing
induced by bupropion but not that of amphetamine. However, alpha-methyl-ptyrosine
combined with reserpine treatment reduced the amphetamine-induced
climbing. It is concluded that both bupropion and amphetamine-induced climbing
through release of dopamine and subsequent activation of 0-1/0-2 receptors
however, the mechanisms by which dopamine is released by these drugs may
differ.
MOHAMMAD-REZA ZARRINDASTPURIFICATIO N OF ALPHA-AMYLASE FROM BACILLUS SUBTILlS LINE # 1024 WITH ATCC 465 http://mjiri.iums.ac.ir/browse.php?a_id=1473&sid=1&slc_lang=en
Alpha-amylase E.C.3.2.1.1. (1,4 glucan, 4 glucanohydrolase) can be obtained
from salivary glands, pancreas and microorganisms such as Pseudomonas
and Asperigllus, as well as muscles and ovarian tubes.1.2 Alpha-amylase from
Bacillus Subtilis #1024(A TCC 465)* was purified with a highest degree of purity
in our laboratory (31.59 U/mg).
The extracellular alpha-amylase was subjected to different purification
techniques such as anionic and cationic exchange chromatography and preparative
electrophoresis.
The final fold of purification was equivalent to 38, which was higher than the
previous reported values, polyacrylamide gel electrophoresis with sodium dodecyl
sulphate (PAGESDS), Laemmeli method, gave a molecular weight of 82000
Daltons.
FARIBA NABATCHlANBINDING OF THE ANTITUMOR DRUG ADRIAMYCIN TO DNA-HISTONE COMPLEXEShttp://mjiri.iums.ac.ir/browse.php?a_id=1472&sid=1&slc_lang=en
Isotherms of the binding of the anthracycIine antibiotic, adriamycin
(adriblastin), to DNA histone complexes was studied by means of spectroscopic
analysis. The results indicated that: (a) binding of adriamycin to histones
reduced the interaction of histones with DNA, (b) binding of the drug to DNA
did not change the binding affinity of histone to DNA and, (c) in the explored
binding range of r<O.1 the binding of adriamycin to DNA-histone complex
proved to be anticooperative with n values of 0.32 for the interaction of histone
with DNA-drug and 0.26 for the binding of DNA to histone-drug complex. The
results suggest the possible participation of his tones in the DNA-drug complex
formation.
AZRA RABBANICRYPTOSPORIDUM IN SHEEP AS A SOURCE FOR HUMAN INFECTIONhttp://mjiri.iums.ac.ir/browse.php?a_id=1471&sid=1&slc_lang=en
Cryptosporidium is a protozoan parasite that infects epithelial cells of the
intestine in a wide variety of vertebrates. During the last decade,
cryptosporidiosis has emerged as a cause of diarrhea in man. Most of the'
patients have AIDS, and have had contact with infected animals. In this study '
510 samples were collected from sheep and examined for detection of this
parasite. The result showed that 26.X6% of animals were colonised. Fattened
sheep were less infected than lambs and those kept for milk.
M REZAEIANASSESSMENT OF NORMAL IgE LEVEL IN 0-14 YEAR OLD HEALTHY CHILDREN IN TEHRANhttp://mjiri.iums.ac.ir/browse.php?a_id=1470&sid=1&slc_lang=en
In order to determine the normal values of total IgE in children, 3270 sera were
taken from 0-14 year old males and females in different parts of Tehran, the capital
of Iran. The technique which was used to measure total IgE was ELISA method
using monoclonal anti-IgE antibody.
The results of this research indicated that the lower value for IgE was detected
in children at birth (X=3.S3 IU/mL), while the highest value was in 10 year old
children (X=74.63 IU/mL). Therefore, it has been concluded that with increasing
age, the IgE level will also increase (r=0.919).
Regardless of the age value, the IgE content in both males and females are the
same. But concerning age and sex, the IgE level in four year old girls was higher
(X=44.92) than similarly aged boys (X=28.2) (P<0.01), while in eight year old
boys, a higher value of IgE (X=66.42) was recorded in comparison to the same
aged girls (X=49 .S9) (p<0.05).
R REZAEIPOORDIETARY SALT REDUCTION POTENTIATES THE ACTION OF HYPOTENSIVE DRUGShttp://mjiri.iums.ac.ir/browse.php?a_id=1469&sid=1&slc_lang=en
Hypertension is a common health problem. Hypotensive drugs and low salt diet are used
in its treatment. This study was designed to compare the effectiveness of a low-salt diet and
drug therapy in the treatment of arterial hypertension. A total of 256 randomly selected patients
with essential hypertension consulting the Non-contagious Diseases Clinic in Shahreza,
Isfahan, Iran, were included in the study for a period of 28 days. They were divided into four
groups. Groups A and B received both methyldopa (250 mg t.i.d.) and hydrochlorothiazide
(daily 10 mg), the former consuming a normal and the second a low-salt diet. Groups C and
D consumed a low-salt and a salt-free diet, respectively, with no drugs. Both treatments A and
B caused statistically significant reductions in blood pressure even after seven days, but treatment
B was much more effective. Reductions in blood pressure in Groups C and D were very
little, even after 28 days. Using the three-way classification of analysis of variance, it was revealed
that interactions existed among the three factors, i.e., age, diet and length of treatment,
as regards lowering blood pressure. We conclude, confirming previous reports in the literature,
that a low-salt diet potentiates the hypotensive action of antihypertensive drugs.
A DJAZAYERIA REVIEW ON HYDATID CYST OF LIVER, WITH A BRIEF REPORT OF 126 CASES FROM FARS PROVINCEhttp://mjiri.iums.ac.ir/browse.php?a_id=1468&sid=1&slc_lang=en
A retrospective review of 126 surgically-proven cases of hydatid cyst of the
liver was performed. Sixty percent of the patients were in the third and fourth
decades of life. The most common presenting complaint was right upper abdominal
pain and/or fullness sensation (92%).
Duration of symptoms was more than two months in 61 %. One third of the
patients had more than one cyst in the liver. Cysts were located in the right
lobe in 68%, left lobe in 19% and both lobes in 13%. In 6%, other intraabdominal
cysts were found during surgery. Cysts were infected in 29% and
were complicated by rupture or fistula formation in 10%. Chest x-rays were
abnormal in 37% (elevated right hemidiaphragm, 22% right lower lobe infiltrate/
atelectasis, 5% right pleural effusion, 13% pulmonary hydatid cyst, 7%).
Plain abdominal films were abnormal in 41 % (curvilinear calcification, 22.5%
hepatomegaly, 24% splenomegaly, 5% air fluid level in the liver cyst, 2.5%).
Upper gastrointestinal barium studies showed extrinsic pressure on the stomach
and duodenum in 40%. Liver scintigraphy was abnormal in 96%, but in
25% there was a discrepancy either in number or location of the cyst(s) when
compared to surgical findings. Angiography was abnormal in all the cases performed.
Literature on pathophysiology, radiologic findings (including CT scan
and ultrasonography), and on surgical and medical therapy of hydatid disease
of the liver is reviewed.
BAHAR BASTANIEXTENSION OF THE CEREBROSPINAL FLUID SPACE INTO THE PROXIMAL TYMPANIC PART OF THE FACIAL NERVEhttp://mjiri.iums.ac.ir/browse.php?a_id=1467&sid=1&slc_lang=en
The author presents an unusual extension of the cerebrospinal fluid space into the
proximal tympanic part of the facial nerve, and points out the clinical and surgical significance
of this anatomical variation.
DRAGOSLAVA DJERICMEASLES EPIDEMICS TN KERMAN, IRANhttp://mjiri.iums.ac.ir/browse.php?a_id=1466&sid=1&slc_lang=en
In early 1990, an outbreak of measles occurred in Kerman, (population 257,
284) Iran. Overall, 475 cases were identified and four died (case fatality ratio 5.4
per thousand). Illness was limited primarily to children below 15 years of age 166
(22.3%) were in children under five, 573 (77%) between 5-14 and six (0.8%) above
15 years of age. The age of the cases ranged from five months to 35 years. The agespecific
attack rates were 3.9, 1.8,7.3 and 2.8 per 1,000 for children under I, 1-4,
5-9, and 10-14 years of age, respectively. Overall, 14 (1.9%) children with measles
were hospitalized for severe complications which consisted mainly of pneumonia,
otitis and gastroenteritis. Based on 745 cases with an immunization record vaccine
efficacy was calculated at 88%, indicating a slight problem with the cold chain or
the vaccine.
The outbreak has been primarily related to low immunization coverage during
the last 10 years. This outbreak again indicates the need to improve vaccine
coverage with the AIK -C existing vaccine, and also the advisability of a revaccination
programme at school age will need to be considered.
MOHAMMAD H. DAlE PARIZI33 CASES OF MULTIPLE MYELOMA WITH MASSIVE BONE DESTRUCTION: REPORT OF A 10-YEAR STUDY IN NORTHEASTERN IRANhttp://mjiri.iums.ac.ir/browse.php?a_id=1465&sid=1&slc_lang=en
The author studied 133, 856 admissions over a ten-year period and found 138 cases of
primary tumors of bone. Of these only 33 were multiple myeloma. Incidence, clinical manifestation,
age, sex and etiology are reported, and the effect of four different chemotherapy
regimens are evaluated.
MANOOCHEHR M. LARISUPRAVALVAR AORTIC STENOSIS IN CHILDREN REPORT OF THIRTEEN CASEShttp://mjiri.iums.ac.ir/browse.php?a_id=1464&sid=1&slc_lang=en
During 15 years from 1975 to 1990, thirteen cases of supravalvar aortic
stenosis were admitted at the pediatrics department of Shahid Rajai Heart
Hospital, Tehran. All patients were subjected to cardiac catheterization and a
angiocardiography. Patients ranged in age from 3.5 years to 14 years with a
mean of 8.7 years.
Seventy seven percent of childen were male. Eight cases (61.5%) had
Williams' syndrome. Hourglass type of supravalvar aortic stenosis was the
most common variant (70%), followed by hypoplastic type (15%) and
membranous type (5%). Peripheral pulmonary stenosis was the most common
associated anomaly and was observed in 23% of patients.
The main purpose of this investigation is to report the results of the study
on supravalvar aortic stenosis and its association with Williams' syndrome in a
group of Iranian children.
SHAHLA ROODPEYMA