Our study is aimed at assessing neurochemical changes
caused by scopolamine (SCP) induced memory impairment
using proton in vivo MR spectroscopy. Adult male Swiss
albino mice (n=32) were used. Mice were divided into
four groups: SCP 0, 1, 3, and 5 (mg/kg). All mice
underwent 1H MR spectroscopy twice: at 30 min and 72
hours after the injection of a solution containing SCP.
Our results are in good agreement with previous
published reports that showed that SCP reduced choline
levels in the brain for about 2 hours. In vivo MR
spectroscopy is a non-invasive method with which to
evaluate the SCP induced memory impairment.

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