Human Immunity to the Meningococcus: The Effect of Immunization With Meningococcal Group C Polysaccharide on the Carrier State

This article, published in the Journal of Experimental Medicine, discusses a small-scale field trial that was carried out in United States military recruits to test the effect of immunization with meningococcal C polysaccharide upon the acquisition of group C meningococci. Over the course of the study, the proportion of unvaccinated recruits who acquired group C meningococci in the three companies studied was 38, 42, and 69 percent. A significantly lower proportion of the individuals vaccinated with group C polysaccharide acquired group C meningococci: 4.6, 24, and 31 percent, respectively.

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