Debutant Callum Robinson wasted a good chance for Ireland but Wales extended their lead again in the 37th minute, Ampadu robbing Jonathan Walters and striding forward to feed Ramsey, with his low drive again leaving Darren Randolph beaten at his near post.

Robinson headed a Seamus Coleman centre over the crossbar as Ireland sought a second-half response, but Wales were rampant and added their fourth in the 55th minute.

Lawrence teed up Bale on the left and Wales' star man fizzed the ball across the box, Roberts controlling with his right before lashing home an unstoppable 20-yard volley with his left.

Although Williams made the most of Ramsey's slip a comeback was never on the cards, leaving Giggs to mull over a superb team performance led by Bale and rising star Ampadu.

What does it mean: Ideal start to Giggs era

As a new competition, the Nations League has been met with plenty of confusion, but Wales have taken a commanding position in their section. Ireland, meanwhile, will need positive results in October's double-header if they are to have a chance of topping Group 4.

Pat on the back: Chelsea teenager Ampadu shows passing range

Ampadu was making only his third international appearance but the Chelsea teenager looked at home in a roving midfield role despite typically lining up in defence. The 17-year-old was involved in two goals and looks to have a fine future in Giggs' side, whichever position he plays.

Ireland named a double-pronged attack of Walters and Robinson but the senior strike partner, recently loaned out from Burnley to Ipswich Town, looked well off the pace. He brought a high ball down under no pressure but still tamely surrendered possession to Ampadu, who then created Wales' third.

- Wales picked up their first ever competitive victory against the Republic of Ireland, having failed to win each of the previous four competitive meetings (D2 L2).- Republic of Ireland have lost back-to-back competitive games for the first time under Martin O’Neill (1-5 v Denmark and 1-4 v Wales).- Wales scored as many goals in this game as they had in their previous 11 meetings with the Republic of Ireland combined.- Gareth Bale became the first player to reach 30 goals for the Welsh national team (two more than Ian Rush, 28).

What's next?

Wales will look to maintain their Nations League momentum when they travel to Denmark - whose senior stars are available after a new commercial deal was reached - on Sunday. A friendly against Poland two days later offers Ireland a chance to rebuild.

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