Other differences between the versions include the fact that the Genesis has a health bar, and the arcade has an icon of the characters face that gets less happy when he takes damage, and starts to flash when he's on the verge of defeat. The arcade version doesn't have the money collecting/spending the Genesis version does(though being an arcade game, there's still money spending to stay in it...).

Regional/port differences, quoted from Wikipedia:"The original Japanese home release of the game featured caricatures that were part of the game's offbeat sense of humor that would've been seen as offensive if they were retained in their western releases. For example, the stage 1 boss was an overweight black woman who attacked by farting (known as "Big Mama" in the home versions). When the player hit Big Mama a certain amount of times, she would temporarily drop to the ground head first and show off her white frilly bloomers underneath her dress and then force herself up again. The arcade versions of the game featured two incarnations of "Big Mama" in the same game, one with light brown skin and another with pink skin. The home console ports gave her dark brown skin and bright red lips in the original Japanese port. The arcade version had the character "fart" occasionally simply as a character animation. The home versions turned it into a kind of "Fart fireball" attack that did damage.

For the subsequent home release in North America and abroad, multiple changes were made. For example, Big Mama (now bearing pink skin) no longer farted; a male stripper character simply appeared in his "Chippendales" outfit from the start, rather than beginning as a homeless looking man who sheds his outer garments to fight. Another change was the substitution of Japanese text featured on in-game billboards with images of scantily clad women (and focusing on crotch images).

This appears to be the same type of "Are you covered?" scantily clad woman joke (a risqué reference to insurance sales) that was featured in Konami's Crime Fighters, another arcade fighting game.

The western console versions of DJ Boy altered the initial encounter with "Big Mama" from the Japanese home version so that she had neon pink skin and instead of farting, threw doughnut-like pastries at the player. The second encounter had her with tan skin in a martial arts outfit (the Japanese version gave her darker skin for this second encounter, while the arcade version simply featured a single encounter then a second encounter with two identical "Big Mama" foes that had light brown and pink skin to distinguish them, rather than an outfit/attack style change).

The home version added cutscenes in which DJ Boy insults his defeated foes. Other alterations include turning the "robot clown" characters into bosses rather than normal enemies, eliminating some of the "homeless guy/stripper", regular enemies, and featuring a boss that was an "evil twin" of DJ Boy (in blue clothing).

The Disk Jockey was Demon Kogure in the Japanese arcade version. However, in the North American and PAL arcade versions, the Disk Jockey was Wolfman Jack, but the in-game sprite is still Demon Kogure. In the home versions, the Disk Jockeys were removed due to memory limitations."