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Welcome to ProMOL.

In recent years, structural genomics
initiatives have generated a large number of protein structures. However,
determining the function of these proteins
through traditional experimental procedures can be a slow process. This disparity has been the
motivation behind the creation of computational tools to predict function from
structural homology. ProMOL is a plugin for the molecular visualization
program, PyMOL, which uses catalytic site homology to predict the function of
proteins with no known function.

make and store motif templates in a growing library of hundreds of existing motif templates

view optimal alignment between a motif template and a query structure

calculate the RMSD and Levenshtein distance between the query protein and its motif hits

request alignment with subsets of the motifs by template source and/or Enzyme Commission number

characterize a structure of unknown function via in silico methods

The ProMol project is sponsored by grants NSF-DUE 0402408, NIGMS 1R15GM078077, NIGMS 2R15GM078077-02, NIGMS 3R15GM078077-02S1, and NSF 1503811 and in part by Rochester Institute of Technology and Dowling College.