Article Tools

Abstract

The murine model of hindlimb ischemia is extensively used in studies on the physiology
and pathology of ischemia and angiogenesis. Traditional non-invasive evaluation methods, such as
laser or ultrasound blood flow perfusion imaging and micro-CT angiography, are limited either by low
resolution or toxic exogenous agents. Relying on intrinsic high optical absorption contrast, we
conduct label-free imaging of subcutaneous blood vasculature in the hindlimb of murine models by
photoacoustic microscopy (PAM). The angiogenesis induced by ischemia in the hindlimb is successfully
observed at high resolution in vivo and non-invasively. PAM is a potentially powerful imaging method
for studying ischemic diseases and resultant angiogenesis.

Cited By

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.