5
 Angioedema is characterized by painless, nonpruritic, nonpitting, and well- circumscribed areas of edema due to increased vascular permeability

6
 most apparent in the head and neck, including the face, lips, floor of the mouth, tongue, and larynx, but edema may involve any portion of the body  may involve the gastrointestinal tract, leading to intestinal wall edema

8
 This deficiency in functioning C1-INH leads to autoactivation of the complement system and release of kininlike mediators, resulting in edema of the subcutaneous or submucosal tissues C’ Pathway (-) C1-INH(-) kallikrein high molecular weight–kinogen bradykinin

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 Epinephrine, corticosteroids, and antihistamines are NOT effective in patients with HAE, AAE, and ACE inhibitor–induced angioedema.  These agents are recommended as second-line therapy. (in cases of angioedema due to allergic causes, these medications are first-line therapies.)

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 94% of angioedemas in ED due to meds  Most of these due to ACE Inhibitors  As many as 22 % require intubation  11% mortality  ARB’s also cause but incidence unknown (case reports)  Mainly losarten