How might trichorhinophalangeal syndrome (TRPS) affect an individual in adulthood?

Information on late onset TRPS symptoms is limited. Joint stiffness, chronic joint pain, and degenerative hip disease (e.g., Perthes-like hip disease) are thought to be relatively common in adults with TRPS. There have been a couple reports of osteopenia or osteoporosis in adults with TRPS. Life expectancy of people with TRPS is normal.[1]

We were unable to find information regarding an association between TRPS and excessive sweating. One case report described a child with a fish-like malodour and TRPS. Her TRPS was due to a novel mutation in TRPS1, however the cause of the malodour was not determined. The association, if any, between the malodour and TRPS is not known.[2]