John Cena still isn’t taking any crap from The Rock. The “Blockers” star just cut an epic promo in response to “Rampage” hero Dwayne Johnson’s toothbrush threat.

On Tuesday’s “Jimmy Kimmel Live,” Johnson, who now cites Cena as one of his “best friends,” reflected on their very real personal problems back in WWE.

Though he says that is now behind them, Johnson then offered up this threat: “If he ever acts up, I’ll knock his teeth so far down his throat, that he’ll [have to] stick a toothbrush up his ass to brush them.”

Cena wasn’t taking that lying down on Wednesday, and he masterfully weaved in some “Blockers” storyline to embarrass his WrestleMania 28 and 29 opponent.

“If you think shoving a toothbrush up my butt is a threat, you’ve got news coming, pal,” he responded. “There’s been a funnel up there, there’s been a parking cone– there’s more traffic in that region than Monday on the 405 in both directions.”

“Down there, it’s like a Mississippi cornfield in a downpour. It is just all mud and vegetation pal,” Cena continued. “Do you really wanna smell what John Cena is puttin’ out?”

The Evolution of John Cena, from WWE's Doctor of Thuganomics to 'Blockers' (Photos)

John Cena has risen through the professional wrestling ranks to become not just one of WWE's most popular Superstars, but one of the most recognizable faces in entertainment today. With "Blockers" set to open soon, let's take a look back at the rise of Cenation.

1999

Cena first appeared as The Prototype, a semi-robotic character, in the Ohio Valley Wrestling organization (essentially, WWE's minor league system).

Ohio Valley Wrestling

2002

Shortly after being called up to WWE's main roster, Cena adopted a new persona: Doctor of Thuganomics, a white rapper who often spat rhymes before his matches and had a penchant for backwards baseball caps and jersey combos. This also served as the beginning of a secondary career for Cena, who recorded a rap album in 2005 (which debuted at 15 on the U.S. Billboard Top 200) and was featured on the WWE soundtrack album "WWE Originals."

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2005

After winning the WWE United States Championship the previous year, Cena defeated John "Bradshaw" Mayfield at WrestleMania 21 to win his first World Championship, solidifying his status as a wrestling star.

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2006

Cena made his feature acting debut in WWE Studios' "The Marine" opposite Robert Patrick. Along with his new wrestling persona as a marine private who sports flags and denim shorts, the movie helped make Cena the new American hero of the WWE.

20th Century Fox

2010

After a guest appearance on "Saturday Night Live," Cena was allowed to display his comedy chops on an episode of USA Network's "Psych," serving as a sign of things to come. Cena would return in 2017 for "Psych: The Movie."

USA Network

2012

After several years of losing and regaining the WWE Championship title, Cena entered into one of the biggest feuds in wrestling history against Dwayne "The Rock" Johnson. After Johnson "screwed" Cena out of a match, Cena issued a challenge against Johnson for WrestleMania 28, exactly one year later. The highest-grossing event in WWE history ended with Johnson defeating Cena with his patented "Rock Bottom" move.

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2013

Cena challenged Johnson to a rematch at WrestleMania 29, a challenge that Johnson accepted. This time, Cena emerged victorious. After the match, the two stars publicly shook hands and embraced, ending their feud.

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2015

2015 turned out to be a breakthrough year for Cena, who appeared in the comedy films "Sisters," "Daddy's Home" and "Trainwreck." He also made a memorable guest appearance as himself in the final season of "Parks and Recreation."

Universal Pictures/NBC

2015 (cont'd)

In addition to his wrestling fans, Cena is known and beloved for his philanthropy, particularly his work with the Make-A-Wish Foundation. Cena began his relationship with the organization in 2004 and has since granted over 500 wishes.

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2016

In 2016, Cena began hosting the Fox reality series "American Grit," which pitted civilians against each other in grueling physical challenges under the guidance of seasoned military vets.

Michael Becker/Fox

2017

Leaning into his image, Cena opened the year by playing a soldier in Doug Liman's war thriller "The Wall" opposite Aaron Taylor-Johnson. He then appeared in "Daddy's Home 2" before voicing a gentle bull with a big heart in "Ferdinand."

Amazon Studios/Twentieth Century Fox

2017 (cont'd)

After hosting the Australian Kids' Choice Awards in 2008, Cena was invited to host the Kids' Choice Awards in 2017. After he charmed and slimed his way into the audience's hearts, he was invited to host again this year.

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2018

Cena will soon appear in his first comedic lead role opposite Leslie Mann and Ike Barinholtz in "Blockers." He will also co-star in the "Transformers" spinoff "Bumblebee" with Hailee Steinfeld, as well as voice recurring villain Baron Draxum in Nickelodeon's new animated series "Rise of the Teenage Mutant Ninja Turtles."

Universal Pictures

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The wrestling favorite seems destined to inherit The Rock’s throne on his quest from the WWE ring to movie stardom

John Cena has risen through the professional wrestling ranks to become not just one of WWE's most popular Superstars, but one of the most recognizable faces in entertainment today. With "Blockers" set to open soon, let's take a look back at the rise of Cenation.