Indications for EYLEA:

Adult:

Give by intravitreal injection. AMD: 2mg (0.05mL) once every 4 weeks (monthly) for the 1st 3 months, followed by 2mg (0.05mL) once every 8 weeks (2 months); some may need the monthly dosing after the 1st 3 months. May also treat with 1 dose every 12 weeks after one year of successful therapy (not as effective); assess regularly. RVO: 2mg (0.05mL) once every 4 weeks (monthly). DME, DR: 2mg (0.05mL) once every 4 weeks (monthly) for the 1st 5 injections, followed by 2mg (0.05mL) once every 8 weeks (2 months); some may need the monthly dosing after the 1st 5 months.

Children:

Not established.

Contraindications:

Ocular or periocular infections. Active intraocular inflammation.

Warnings/Precautions:

Monitor for endophthalmitis and retinal detachments during the week following injection. Monitor intraocular pressure and perfusion of optic nerve head after injection. Potential risk of arterial thromboembolic events (eg, nonfatal stroke or MI, vascular death). Pregnancy. Females of reproductive potential should use effective contraception prior to initial dose, during therapy, and for at least 3 months after last injection. Nursing mothers: not recommended.