Abstract

Introduction

Early comprehensive geriatric assessment (CGA) with good history-taking is essential in assessing the older adult.

Case presentation

Our patient, a 75-year-old Caucasian woman, was originally admitted to hospital for investigation of iron deficiency anemia. During admission, she developed pneumonia and new intermittent atrial fibrillation in association with a right-sided weakness, which was felt to be new at the time.

Following this episode, she was treated for a further chest infection and, despite clinical improvement, her inflammatory markers failed to settle satisfactorily.

She was transferred to her local hospital for a period of rehabilitation where further neurological findings made the diagnosis of solely stroke questionable; these findings prompted further history-taking, investigations and input from other disciplines, thereby helping to arrive at a working diagnosis of vasculitic neuropathy.

Conclusions

The case aims to highlight the importance of taking a good history and performing an early comprehensive assessment in the older adult.

During the same admission, she developed a hospital-acquired pneumonia and new intermittent atrial fibrillation.

Coinciding with this period, she developed a new dysphasia and what was perceived to be a ‘new’ right-sided weakness. A computed tomography (CT) brain scan showed no acute change and she was treated as a patient with ischemic stroke, given the clinical findings.

She was treated for a further pneumonia in hospital and also underwent investigations such as a CT pulmonary angiography (CTPA) scan, which ruled out pulmonary embolism but confirmed partial left lung collapse; subsequent bronchoscopy was negative for malignancy. Her inflammatory markers remained elevated with her C-reactive protein (CRP) level approximately 140 and white cell count (WCC) 14 but she remained mentally alert and made clinical improvement. Her repeat chest X-rays were also unchanged. Given the clinical improvement, she was deemed suitable for transfer for stroke rehabilitation to her local hospital in August 2013. Her medications on transfer were: Novomix 30 twice daily (later stopped due to low blood sugar levels); clopidogrel 75 mg; quinine sulphate 200 mg; ranitidine 150 mg twice daily; folic acid 5mg; and digoxin 125mcg.

In the Rehabilitation and Assessment Directorate (RAD), the assumption was that our patient had suffered a stroke causing a right-sided weakness, as per the handover pre-transfer, however, further neurological features were detected on the post-take ward round as listed below: right lower motor neurone seventh nerve weakness; ptosis right greater than left; bilateral wrist drop; bilateral foot drop; generalized reduced tone and reduced power in all four limbs: right arm 3 out of 5, right leg 0 out of 5, left arm 3 to 4 out of 5, and left leg 2 out of 5. No comment was documented regarding sensation.

The chronicity of the neurological features was uncertain at this point as they did not appear to have been previously documented and the immediate reaction was to exclude an acute neurological process. Fortunately, her daughter was present during the ward round that day and a collateral history revealed our patient had ‘possibly’ been like this for 18 months or more. This led to a degree of reassurance with regard to the fact that the neurological findings were unlikely to be acute.

Further discussion with our patient’s son confirmed that her mobility had gradually deteriorated over a two-year period; from his perception, the only novel finding was alteration of our patient’s speech at the time of a presumed ischemic stroke.

Given the account from our patient’s son and daughter, her general practitioner (GP) was also contacted and it was reported that our patient had been referred to various disciplines for poor mobility but had failed to attend her appointments; she had been diagnosed with a Bell’s palsy and third nerve palsy in 2011, which had been attributed to her diabetes. Interestingly, a previous trial of steroids from her GP for presumed arthropathy had resulted in clinical improvement.

Our patient underwent several investigations, included below, as part of the investigative and diagnostic process. In addition, for the complete history, her blood pressure was 104/53 mmHg and heart rate was 57 beats/minute with no documented murmurs.

Imaging

A magnetic resonance imaging (MRI) brain scan showed atrophy with small vessel disease, high signal at the left corona radiata and adjacent left occipital horn. An MRI cervical spine scan revealed no gross abnormality and a CT scan of her abdomen and pelvis showed extensive diverticular disease only.

Blood investigations

Blood tests showed her Hb level was 85g/dL; WCC was 11.1; platelets were 512, MCV was 89 and her hematinics were normal. Urea and electrolytes test (U&E), liver function test (LFT), and calcium test results were normal. Her albumin level was l0, CRP level was 120 and her baseline HBA1c level was 57mmol/L (normal range 20 to 42mmol/L). Her cholesterol level was unavailable and her blood and urine cultures were negative.

Invasive investigations

Neurology unit investigations

Multi-specialist input from several disciplines including rheumatology and neurology was also requested.

The neurologist documented the following clinical findings: right ptosis; right facial weakness; generalized weakness right greater than left; profound distal greater than proximal weakness and wasting left greater than right; upper limb greater than lower limb; sensation distally decreased in lower limbs; and areflexia.

The general consensus was that our patient was probably manifesting a peripheral neuropathy secondary to a vasculitis (the type of which was difficult to classify); the neuropathy had been possibly exacerbated by a recent stroke; the stroke may have been part of the vasculitic process itself or could have been related to atrial fibrillation.

It was felt that a nerve biopsy would have little else to contribute to the diagnosis and simultaneously might induce patient distress and was therefore avoided.

Given her history of T2DM, our patient was cautiously commenced on a trial of prednisolone 40mg with azathioprine on 13 September 2013; additional oral antidiabetic therapy on advice of the diabetic team was commenced and gradual step-down of steroid therapy was planned.

Within days of steroid initiation, our patient’s inflammatory markers improved. Her CRP level fell to 36 and her WCC to single figures.

Her right wrist drop showed slight improvement from initial investigations to the point of discharge. There was, however, little neurological and functional improvement otherwise.

Our patient remained bedbound and her hospital stay was complicated by a pressure ulcer, which had completely healed prior to discharge to a care home six months later. On discharge her blood test results revealed Hb of 94, WCC of 11.5, her platelets were 380 and MCV 90.8, her CRP level was 20 and albumin level was 28. She remained clinically stable and her treatment goal was to help prevent any further neurological deterioration.

Discussion

Our patient had been admitted for investigation of iron deficiency anemia and suffered recurrent illness during admission precipitating a prolonged hospital admission and eventual transfer to her local hospital for stroke rehabilitation.

Looking back at the case, our patient did have a stroke as was confirmed on MRI; however, the fact that she had bilateral and long-standing neurological signs evaded detection for a considerable period of time.

It is only after a thorough history-taking, examination and comprehensive geriatric assessment post transfer to the rehabilitation unit that her illness was diagnosed. Though there may not have been a great change to her overall quality of life, an underlying debilitating diagnosis was established with a treatment goal attempting to prevent further neurological deterioration.

It can be argued that had a comprehensive geriatric assessment taken place earlier, keeping in mind that she had displayed neurological symptoms some 18 months previously, would earlier initiation of treatment been more effective in improving her quality of life? Should the fact that she had failed to attend appointments prompted further thinking as to the underlying factor causing nonattendance at clinic appointments, keeping in mind that there was a history of neurological signs?

Conclusions

The case aims to highlight the importance of taking a good history and performing a comprehensive assessment, especially in the older adult [1].

Consent

Written informed consent was obtained from the patient’s daughter for publication of clinical details and this case report. The patient verbally consented to publication of the case report but was unable to sign the document due to her wrist drop. A copy of the written consent is available for review by the Editor-in-Chief of this journal.

Abbreviations

ACE:

angiotensin-converting enzyme

ANA:

antinuclear antibody

ANCA:

antineutrophil cytoplasmic antibody

CEA:

carcinoembryonic antigen

COPD:

chronic obstructive airways disease

CRP:

C- reactive protein

CT:

computed tomography

CTPA:

CT pulmonary angiogram

EMG:

electromyography

ESR:

erythrocyte sedimentation rate

GI:

gastrointestinal

GP:

general practitioner

Hb:

hemoglobin

IgA:

immunoglobulin A

LFT:

liver function test

MCV:

mean cell volume

MPO/PR3:

myeloperoxidase/proteinase 3

MRI:

magnetic resonance imaging

RAD:

Rehabilitation and Assessment Directorate

T2DM:

type 2 diabetes mellitus

U&E:

urea and electrolytes test

WCC:

white cell count

Declarations

Acknowledgements

A special thank you to Dr Medhat Zaida, Dr Martin Perry, Dr Tracy Baird, Dr Neil McGowan for providing their valuable input and support in the diagnosis and management of this case. A big thanks to Dr Iain Keith, Dr Christopher Foster and also to Dr Gautamananda Ray for providing their valuable opinion when the manuscript was being drafted and a special thanks to all the other medical, nursing and allied health professionals involved in our patient’s care.

Competing interests

The authors declare that they have no competing interests.

Authors’ contributions

DG was the locum registrar involved with management of the patient, initiating and carrying out investigations during admission, making specialist referrals, liaising with other specialities, acquiring data, drafting and designing the manuscript. PK was the consultant under whom our patient’s care was allocated. PK was also involved in initiating investigations during admission, liaising with other specialities, acquiring data, drafting and designing the manuscript. Both authors read and approved the final manuscript.

Reference

Copyright

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.