Your Smart Phone could be a High-Resolution Microscope

Australian scientists have invented a simple and cheap way of making a high-powered lens that can transform a smart phone into a high-resolution microscope. Costing less than a cent, the lenses promise a revolution in science and medicine in developing countries and remote areas.

The lens fabrication technique was invented by Dr. Steve Lee from The Australian National University (ANU) Research School of Engineering, who collaborated with Dr. Tri Phan from Sydney’s Garvan Institute of Medical Research to find ways to transform the lentil-sized lens into a medical imaging tool.

The lenses are made by using the natural shape of liquid droplets.

“We put a droplet of polymer onto a microscope cover slip and then invert it. Then we let gravity do the work, to pull it into the perfect curvature,” Lee said.

“By successively adding small amounts of fluid to the droplet, we discovered that we can reach a magnifying power of up to 160 times with an imaging resolution of four micrometers.”

The polymer, polydimethylsiloxane (PDMS), is the same as that used for contact lenses, and it won’t break or scratch.

“It would be perfect for the third world. All you need is a fine tipped tool, a cover slip, some polymer and an oven,” Lee said.

The first droplet lens was made by accident.

“I nearly threw them away. I happened to mention them to my colleague Tri Phan, and he got very excited,” Lee said.

“So, then I decided to try to find the optimum shape, to see how far I could go. When I saw the first images of yeast cells I was like, ‘Wow!’”

Lee and his team worked with Phan to design a lightweight 3D-printable frame to hold the lens, along with a couple of miniature LED lights for illumination, and a coin battery.

The technology taps into the current citizen science revolution, which is rapidly transforming owners of smart phones into potential scientists. There are also exciting possibilities for remote medical diagnosis.

Phan said the tiny microscope has a wide range of potential uses, particularly if coupled with the right smartphone apps.

“This is a whole new era of miniaturization and portability — image analysis software could instantly transform most smartphones into sophisticated mobile laboratories,” Phan said.

“I am most able to see the potential for this device in the practice of medicine, although I am sure specialists in other fields will immediately see its value for them.”

Lee said the low-cost lens had already attracted interest from a German group interested in using disposable lenses for tele-dermatology.

“There are also possibilities for farmers,” he said. “They can photograph fungus or insects on their crops, upload the pictures to the Internet where a specialist can identify if they are a problem or not.”

The lens-making technology is described in the latest issue of Biomedical Optics Express, published by The Optical Society.