Abstract Information and knowledge are one of the most valuable assets of an organization and as a source for the survival of organizations is vitally necessary. Today, for having a continuous presence and stability in the commercial and competitive world, an organization should work on Knowledge-based approach. In order to use this valuable source correctly, knowledge management is on the agenda of the leading organizations. Accordingly, the present study was conducted as a descriptive-analytical and cross-sectional one to assess the impact of knowledge management on the level of confidence toward the information technology among staff working at Mashhad University of Medical Sciences. The sample size was estimated about 377 by Morgan table and selected by simple randomization method. Data were collected by a researcher-made questionnaire which its reliability and validity were confirmed; and then Data analysis was performed by SPSS version 16th. Total score of trust in IT and knowledge management among employees were estimated 3.14 ± 0.76 and 3.39 ± 0.61, respectively. According to the results, there was a direct correlation between knowledge management and staff confidence in information technology (p-value ≤ 0.001, r = 0.436). Moreover, the positive correlation among the examined factors were assigned to components of recording and maintenance knowledge (p-value ≤ 0.001, r=0.472).Therefore, it appears essential for health managers to be successful in their organizational mission to focus on using the Information Technology as well as upgrading and updating of staffs’ knowledge of IT.

21-Salavati, A, Haghnazar, F 2009,Analysis of factors affecting the establishment of a knowledge management system at the headquarters of the National Iranian Oil Company.Journal of Perfection of management, Vol.3, No.10, Pp.77-104.