Hondo:
I have a mix of Peco 100 and 75. Plus a few weird things.
I don't have problems with modern wheels on the code 75. Most of my problems are from British trains bought before 1980, possibly before 1970.
There have been cheap N. American prototype wheels that don't like it -- they have what we called "Pizza cutter" flanges. On most stock (except locomotives) the wheelsets can be popped out and replaced.