Trial Information

This study is for patients with a blood condition or myelodysplasia (bone marrow disease)
which has either not responded to treatment or is not treatable by conventional/routine
medical treatments. Bone marrow transplantation is a medical treatment that involves giving
high doses of chemotherapy followed by the transplantation of the blood-forming and immune
cells from a relative or from a "matched" unrelated person through the National Marrow Donor
Program, in an attempt to cure disease in the recipient (the person receiving the donated
cells). Nonmyeloablative (bone-marrow preservation) bone marrow transplantation is a
relatively new technique in which lower than usual doses of chemotherapy are given before
transplantation, in hopes of reducing adverse side effects of the chemotherapy in transplant
patients. Nonmyeloablative bone marrow transplantation has several advantages which doctors
have determined are beneficial for this condition.

This research is being done because the complication of graft-versus-host disease can be bad
for a person and there is no completely safe and effective way to prevent this complication.
We know that cyclosporine helps but would like to know if the addition of basiliximab,
given with cyclosporine, will decrease the incidence and/or severity of graft-versus-host
disease after a transplant known as nonmyeloablative or "mini" transplant.

Inclusion Criteria:

- Acute myelogenous leukemia:

- Second or subsequent remission; patient over 18 yrs of age.

- Relapsed after autologous HC transplant, over 18 years of age.

- First remission, Philadelphia chromosome + over age 18.

- Secondary AML, in first or subsequent remissions.

- Acute lymphocytic leukemia:

- Philadelphia chromosome + over the age of 50, first or subsequent remission.

- Relapse following Autologous HC transplantation, ages over 50.

- Second or subsequent remission over the age of 50

- Chronic myelogenous leukemia:

- First or second chronic phase over the age of 18.

- Accelerated phase over the age of 18.

- Must have failed or been intolerant to a standard tyrosine kinase inhibitor.

- Chronic lymphocytic leukemia:

- Failed nucleoside-based therapy, ages >18.

- Myelodysplasia:

- All-risk categories, age greater than 18.

- Non-Hodgkin's Lymphoma, less than 76 years of age

- Relapsed diffuse aggressive NHL (intermediate and high grade) that fails to
achieve CR or PR to conventional salvage chemotherapy.

- Patients with marginal zone lymphoma or gastric MALT type associated with
Helicobacter pylori infection must have progressed after receiving appropriate
antibiotic therapy as well as three or more regimens as described above

- Mantle cell, ages 18-75.

- Hodgkin's Disease, ages 18-75.

- Relapsed or refractory disease after autologous transplant.

- Multiple Myeloma, ages 18-75

- Recurrent disease after two medical therapies

- Relapse following autologous transplant

- Myelofibrosis, age greater than 18 years

- Severe aplastic anemia (refractory to immunosuppressive therapy); age greater than 18
years

- Patients with aplastic anemia must have marrow cellularity ≤ 10% plus 2 of the
following:

- Must have a fully HLA-matched (10 of 10 Antigen matched) related or unrelated
donor, eighteen years of age or older, who is capable of undergoing GCSF
mobilization and apheresis

Exclusion Criteria:

- Active CNS disease (the presence of leukemic blasts in the CSF)

- Pregnancy or breast-feeding.

- Inability to give informed consent.

- AST, ALT, total bilirubin >3x upper limit of normal.

- Creatinine > 2 or creatinine clearance < 50mL/hr. If patient has a creatinine of > 2
or creatinine clearance < 50mL/hr and it is due to the disease process then the
patient will not be excluded based on this.

- Fractional shortening by echocardiogram not within normal limits per institution or
LVEF of < 40 %.

- Pulmonary function: DLCO not within institutional normal limits or DLCO less than
45% of normal predicted, corrected for anemia

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