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Publications13

Unbiased proteomic analysis of proteins interacting with the HIV-1 5'LTR sequence: role of the transcription factor Meis

A TachenyLaboratory of Biochemistry and Cell Biology URBC, Namur Research Institute for Life Sciences, University of Namur, 61 rue de Bruxelles, 5000 Namur, BelgiumNucleic Acids Res 40:e168. 2012

..Combined with an in silico analysis of the DNA sequence of interest, this approach provides a powerful approach to select the interacting candidates to validate functionally by classical approaches...

miR-212/132 expression and functions: within and beyond the neuronal compartment

..Of the five antioxidants tested, only curcumin was able to inhibit IkappaBalpha degradation upstream and, hence, NF-kappaB DNA-binding activity and NF-kappaB-dependent expression of IL-6 downstream...

mtCLIC is up-regulated and maintains a mitochondrial membrane potential in mtDNA-depleted L929 cells

..These findings suggest that mtCLIC could be involved in mitochondrial membrane potential generation in mtDNA-depleted cells, a feature required to prevent apoptosis and to drive continuous protein import into mitochondria...

CREB activation induced by mitochondrial dysfunction is a new signaling pathway that impairs cell proliferation

..This mechanism of action was quite different from that of the majority of cytotoxic compounds used in the chemotherapy of cancer. Compound 4b possessed better cytotoxicity than the other compounds...

Synthesis and cytotoxic activity of benzopyranoxanthone analogues of benz

..cis-3,4-Diacetoxy-5-methoxy-2,2-dimethyl-3,4-dihydro-2H,6H-benzo[b]pyrano[2,3-i]xanthen-6-one, the most active among the new compounds, was more potent than acronycine in inhibiting the proliferation of L1210 murine leukemia cells...

2,2-Dimethyl-2H-anthra[2,3-b]pyran-6,11-diones: a new class of cytotoxic compounds