Abstract

Non-coding RNAs (ncRNAs) play essential roles in multiple aspects of the life cycles of herpesviruses and contribute to lifelong persistence of herpesviruses within their respective hosts. In this chapter, we discuss the types of ncRNAs produced by the different herpesvirus families during infection, some of the cellular ncRNAs manipulated by these viruses, and the overall contributions of ncRNAs to the viral life cycle, influence on the host environment, and pathogenesis.

Notes

Acknowledgements

We thank the past and present members of Jay Nelson’s laboratory at VGTI for discussions, and apologize to the many scientists whose work we could not mention due to space limitations. This work was supported by a Pathway to Independence Award CA175181 from the National Cancer Institute to R.L.S. Support for M.H. comes from NIH grant AI21640.

Hutchinson NI, Tocci MJ (1986) Characterization of a major early gene from the human cytomegalovirus long inverted repeat; predicted amino acid sequence of a 30-kDa protein encoded by the 1.2-kb mRNA. Virology 155(1):172–182CrossRefGoogle Scholar