CSF (cerebrospinal fluid) CaBP may be a useful
marker for examining the Purkinje cell involvement in cerebellar
diseases.
PMID: 8229048

abundantly expressed in cerebellar Purkinje cells
and show increased immunoreactivity (CaBP-IR) when challenged with
glutamate or an analog agonist for the ionotropic glutamate receptor
(iGluR).
PMID: 15143625

Purkinje cell is the only site of expression in
the cerebellum of the calcium binding protein calbindin-D28k.
PMID: 15110084

an EF-hand CaBP, which is highly expressed in
Purkinje cells (PCs) where it acts primarily as a cellular Ca++
buffer.
PMID: 11379822

an intracellular calcium binding protein that is
expressed in the cell bodies, nuclei, dendrites, and axons of nearly
all Purkinje neurons of the rat cerebellum.
PMID: 8896818

At E12-14, anti-ELF localized to axonal sprouts
in the developing neuroblasts of cortex and purkinje cell layer of
the cerebellum, as well as in cell bodies in the diencephalon and
metencephalon and
appears
to be a marker of purkinje cell
precursors in the cerebellum. PMID: 12149647

GABA-T (gamma-aminobutyric acid transaminase)

GABA-T were detected throughout the brain and
were detected largely in the medial and ventral regions of the
telencephalon, nucleus preopticus, nucleus recessus lateralis of the
hypothalamus, and Purkinje cell layer of the cerebellum, is a
Purkinje cell
differentiation
marker.
PMID: 17362888,
PMID: 15236231

Type 1 IP3R (IP3R1) is dramatically enriched in
Purkinje neurons in cerebellum and neurons in other regions,
consistent with previous studies. By contrast, IP3R2 is only
detected in glia, whereas IP3R3 is predominantly neuronal, with
little detected in glia. IP3R3 is enriched in neuropil, especially
in neuronal terminals (which often contain large dense core
vesicles) in limbic and basal forebrain regions including olfactory
tubercle, central nucleus of the amygdala, and bed nucleus of the
stria terminalis.
PMID: 10096607

L7

found only in the cerebellum and confined to the
Purkinje cells, is a Purkinje cell-specific
marker.
PMID: 2483097

Purkinje cell-specific marker, is important in
controlling the development and/or motor control function of
Purkinje cells.
PMID: 12399102,
PMID: 15548431

MAP2 (microtubule-associated
protein 2)

the distribution of MAP2 in Purkinje cells is not
determined solely by its binding to tubulin. Other factors must be
involved and these appear to be related to dendritic morphology and
possibly to branching.
PMID: 2398141

can be used to reveal the dendritic development
of Purkinje cells.
PMID: 2350879

mainly localized in the neuronal cells throughout
development, with the expression in Purkinje cell dendrites being
especially remarkable in the growth of arborization from postnatal
day 3 to day 20.
PMID: 3418347

MAP-120 kDa

brain- and neuron-specific and is localized
predominantly in Purkinje cell bodies and dendrites in the
cerebellum and in dendritic compartments of pyramidal and granule
neurons in the hippocampus and dentate gyrus.
PMID: 1945041

NMDA-NR1 (NMDA-R1 receptor subtype)

The adult cerebellar Purkinje cell is an
exceptional neuron in the central nervous system in that it
expresses high levels of NMDAR1 (NR1) mRNA without expressing any
NMDAR2 (NR2) mRNAs. The mature Purkinje cell produces NR1 protein
that is ready to combine with NR2 to form functional NMDARs in
excitatory synapses.
PMID: 12603279

NMDARs transiently produce membrane current in
Purkinje cells and may serve as one of the epigenetic factors that
support the survival of Purkinje cells in vitro.
PMID: 8764653

present on the proximal dendrite of the
cerebellar Purkinje cell of the guinea pig.
PMID: 2829997

P400 protein is a 250 kd glycoprotein,
characteristic of the cerebellum, which is accumulated at the
endoplasmic reticulum, at the plasma membrane and at the
post-synaptic density of Purkinje cells.
PMID: 2153079

identical to the inositol 1,4,5-trisphosphate
receptor protein, is a glycoprotein closely associated with the
membranes of Purkinje cells.
PMID: 1699178

a Purkinje cell-characteristic plasma
membrane-associated glycoprotein, which is also present at the
postsynaptic density and endoplasmic reticulum and that the
expression of P400 protein in Purkinje cells is closely associated
with the growth of their dendritic arborization.
PMID: 2707487

distributed abundantly in the soma, the dendritic
arborization, and the axon of the Purkinje cell.
PMID: 3141586

a glycoprotein of high apparent molecular weight
which is abundant in isolated cerebellar Purkinje cells.
PMID: 121073

P450scc (P450 side-chain cleavage)

appears in the rat Purkinje cell immediately
after its differentiation. The expression of this enzyme may remain
during neonatal development and in adulthood.
PMID: 9421408

predominantly localized in the Purkinje cell body
and dendrites of the fetal and newborn cerebellum, with weaker
immunoreactivity in a few cells of the inner granular layer.
PMID: 11020552

Immunohistochemical analysis indicated that
Purkinje cells in the Xenopus cerebellum were specifically
immunostained with the P450scc antibody.
PMID: 10098534

occurs in the rat cerebellar Purkinje cell after
differentiation and remains during neonatal development and into
adulthood.
PMID: 9421408,
PMID: 9927309

two major cGMP-hydrolyzing PDEs specifically and
differentially expressed in the Purkinje neurons of mouse
cerebellum. PDE5 was found in all Purkinje neurons, whereas PDE1B
was detected only in a subset of these cells, suggesting that
individual Purkinje cells may differentially regulate cGMP,
depending on the PDE isozymes expressed.
PMID: 12878685

PDE5 is expressed in all Purkinje neurons while
PDE1B is expressed in only a subset of these neurons.
PMID: 15312979

PDE9A

PDE9A mRNA was widely distributed throughout the
rat and mouse brain, with the highest expression observed in
cerebellar Purkinje cells.
PMID: 14501210

heavily stained the more distal dendrites of the
Purkinje cells and, within the resolution of the fluorescence
procedure, colocalized with calbindin-D28k. By using alkaline
phosphatase-conjugated second antibody, PMCA was again localized to
the peripheral soma, to a segmental pattern in dendrites, and to
presumed spiny elements. The soma periphery and dendrites of
Purkinje cells of the rat cerebellum were also prominently stained
with anti-PMCA antibody and compared to parvalbumin localization.
PMID: 8265654

PMCA2 (plasma membrane Ca(2+)-transport ATPase-2)

a major calcium pump, is expressed at
particularly high levels in Purkinje neurons.
PMID: 17150372

Purkinje cells contain the highest diversity of
PMCA isoforms of the cerebellar cortex since the moment of its
morphogenesis. From embryonic day 15, the highly expressed in the
whole Purkinje cell, while PMCAs 1 and 3 had a more restricted
distribution in the soma and dendritic branches, and these
distributions were evolving according with cell maturation.
PMID: 17385688

SERCA

mainly distributed in Purkinje neurons, whereas
the PMCA seems to be expressed initially in climbing fibers,
shifting to soma and spiny branchlets of Purkinje cells at late
embryonic stages.
PMID: 16104848

Zebrin II/aldolase C is a 36 kDa polypeptide
expressed by Purkinje cells in the cerebellum of elasmobranchs,
teleosts, birds, and mammals, and by octavolateralis pyramidal cells
in developing teleosts.
PMID: 9406878

zebrin II recognizes a single 36-kD polypeptide
in Purkinje cells in the rat and fish cerebellum.
PMID: 1955583