Paraneoplastic Isaacs Syndrome: A Case Series and Review of the Literature

Journal of Clinical Neuromuscular Disease, 05/30/2012Rana S et al.

The case series highlights the association of Isaacs' syndrome with a variety of neoplasms both malignant and benign. The report also underscores the fact that Isaacs' syndrome may be diagnosed several years before a neoplasm is discovered. In the cases, Isaacs' syndrome overlapped with other neuromuscular disorders, that is, myasthenia gravis in a patient with thymoma and chronic inflammatory demyelinating polyneuropathy in a patient with lymphoplasmacytic lymphoma with paraproteinemia. To the authors knowledge, this is the first report of an association between Isaacs' syndrome with lymphoplasmacytic lymphoma and a spinal cord hemangioblastoma.