A patient is described in whom electrocardiographic changes simulating acute nontransmural myocardial infarction occurred in association with head trauma. Despite extensive noninvasive investigation, including computerized axial tomography and myocardial scanning, no acute structural central nervous system or cardiac abnormality could be detected. A review of the literature failed to reveal a similar case of these electrocardiographic changes occurring in the absence of organic brain or cardiac pathology.