A slang term for vagina, it stems from the work Vajookie, which means the same thing albeit much more obviously. Jukebox is generally not to be used in a sexual sense, since it is not at all a sexy word, and should be used to refer to a pussy specifically and probably not as an insult, unless you want to sound stupid.

Charlie: Molly, I'm going to punch you in the jukebox unless you give me a pink motherfuckin starburst right the fuck now!
Molly: But Charlie, this is the last one I have, and my juke still hurts from yesterday!

a sexual diversion to encourage a man to be more active in bed:
right when the girl is close to coming (but not, because he's not working it right), shove something up his ass really fast and then hold on tightly. He'll likely squirm wildly to try to dislodge it and the girl can get her orgasm.