Credit: The Associated Press

Louisville quarterback Teddy Bridgewater fires a pass in the second quarter of a NCAA college football game against Ohio University in Louisville, Ky., Sunday, Sept. 1, 2013. Bridgewater, playing three quarters, threw for 355 yards, including five touchdowns as Louisville won 49-7.

Credit: The Associated Press

Louisville coach Charlie Strong, left, talks with wide receiver Kai De La Cruz (12) and fullback Griffin Uhl (39) during a time-out in the second quarter of an NCAA college football game in Louisville, Ky., Sunday, Sept. 1, 2013 against Ohio University. (AP Photo/Garry Jones)

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LOUISVILLE, Ky. — Eastern Kentucky will take a short road trip to face a steep challenge Saturday at No. 8 Louisville.

The Colonels travel 104 miles west to square off against the Cardinals, who believe they can play even than their season-opening 42-point rout of Ohio. Oddsmakers had listed Louisville as a 41-point favorite earlier in the week before removing the line.