Great site and good job! I'd found it a year or so back and used it successfully to do some reaction searching. I've come back again recently (with updated java, version # 8, build 161) but trying to do some reaction searching gives me an error from the java applet "No response from server", and was wondering if I could get some advice, please?

Presumably, it's my version of java? or IE (IE11, version 11.0.9600.18977)?

you didn't do anything wrong. Since Java applets are almost not supported by modern browsers anymore, my applets on the openmolecules.org site were less and less used. In addition I had a server crash with harddisk failure last year. When I rebuilt the services, I simply didn't reinstall and start the webreactions service, because I had a lot to do with the forum. Finally, I forgot about webreactions and nobody ever complained.

Nevertheless, I have restarted the server now. In order to address the applet issue, I have also created a client application that works independent of any browser. Just download the attached jar file and double click it. Provided that you have a working Java runtime installed, the webreactions client starts then immediately in a new window and lets you draw a reaction and search the server database. There are no browser related applet issues anymore.

If more people are interested, I may focus more on reactions, add reaction search into DataWarrior and potentially work on synthesis planning...