IMMUNIZATIONS

Many canine diseases can now be prevented through vaccination. A vaccination schedule prepared by your veterinarian can thus greatly contribute to good health and longer life span for your dog. Below are the most important diseases for which vaccines are currently available.

Rabies: one of the world's most publicized and feared diseases, is almost always fatal. Rabies virus attacks the brain and central nervous system, and is transmitted to humans chiefly through the bite of an infected animal.

Canine Distemper: is a widespread, often fatal disease. All dogs should be vaccinated against distemper, starting with distemper-measles vaccination at 6 to 9 weeks of age.

Canine Parainfluenza: is another cause of kennel cough. Although Parainfluenza is often a mild respiratory infection on otherwise healthy dogs, it can be severe in puppies or debilitated dogs.

Canine Parvovirus: infection is a disease of widespread distribution which may cause severe dehydrating diarrhea in dogs of varying ages. Parvovirus infection is especially dangerous for puppies.

Canine Coronavirus: infection is a highly contagious intestinal disease causing vomiting and diarrhea in dogs of all ages. Especially in your puppies, dehydration from Coronavirus infection can be life threatening.

Canine Leptospirosis: is a bacterial infection which may lead to permanent kidney damage. The disease is easily spread to other pets and to humans.

Canine Bordeteila (B. bronchiseptica): may contribute to kennel cough. This bacterial infection can occur alone or in combination with distemper, Adenovirus Type-2 infection, Parainfluenza, and other respiratory problems.

The vaccination of puppies (puppy shots) is one of the crucial steps in assuring the puppy will have a healthy and happy puppyhood. The who, what, why, when, where, and how of vaccinations are complicated, and may vary from puppy to puppy. Always consult with your veterinarian to determine which vaccines are appropriate for your puppy. To better understand vaccines, it is important to understand how the puppy is protected from disease the first few weeks of its life.

Protection from the mother (maternal antibodies)

A newborn puppy is not naturally immune to diseases. However, it does have some antibody protection which is derived from its mother's blood via the placenta. The next level of immunity is from antibodies derived from the first milk. This is the milk produced from the time of birth and continuing for 36-48 hours. This antibody-rich milk is called colostrum. The puppy does not continue to receive antibodies through its mother's milk. It only receives antibodies until it is two days of age. All antibodies derived from the mother, either via her blood or colostrum are called maternal antibodies. It must be noted that the puppy will only receive antibodies against diseases for which the mother had been recently vaccinated against or exposed to. As an example, a mother that had NOT been vaccinated against or exposed to parvovirus, would not have any antibodies against parvovirus to pass along to her puppies. The puppies then would be susceptible to developing a parvovirus infection.

Window of susceptibility

The age at which puppies can effectively be immunized (protected) is proportional to the amount of antibodies the puppy received from its mother. High levels of maternal antibodies present in the puppies' bloodstream will block the effectiveness of a vaccine. When the maternal antibodies drop to a low enough level in the puppy, immunization by a commercial vaccine will work.

The antibodies from the mother generally circulate in the newborn's blood for a number of weeks. There is a period of time from several days to several weeks in which the maternal antibodies are too low to provide protection against the disease, but too high to allow a vaccine to work. This period is called the window of susceptibility. This is the time when despite being vaccinated, a puppy or kitten can still contract the disease.

When should puppies be vaccinated?

The length and timing of the window of susceptibility is different in every litter, and even between individuals in a litter. A study of a cross section of different puppies showed that the age at which they were able to respond to a vaccine and develop protection (become immunized) covered a wide period of time. At six weeks of age, 25% of the puppies could be immunized. At 9 weeks of age, 40% of the puppies were able to respond to the vaccine. The number increased to 60% by 16 weeks of age, and by 18 weeks, 95% of the puppies were protected by the vaccine. Almost all researchers agree that for puppies we need to give at least three combination vaccinations and repeat these at one year of age.

Drs. Foster and Smith prefer to vaccinate puppies with a combination vaccine at six weeks of age initially, with boosters given every three weeks until the puppy is about sixteen weeks of age. We feel that this schedule will help protect the widest range of dogs. We realize that with our protocol, we will be vaccinating some dogs that are not capable of responding, and we will be revaccinating some dogs that have already responded and developed a protection. But without doing an individual test on each puppy, it is impossible to determine when the puppy's immune system will be best able to respond. We also realize that in the face of an infection, due to the window of susceptibility, some litters will contract a disease (e.g., parvo) despite being vaccinated. By using quality vaccines and an aggressive vaccination protocol, we can make this window of susceptibility as small as possible. Our vaccination protocol may not be right for every puppy. Puppies that are not exposed to other dogs and have a very small chance of coming in contact with parvovirus, may not need to be vaccinated as frequently. At the same time, some 'high risk' puppies may need a more intense and aggressive vaccination program. It is best to work with your veterinarian on a vaccination protocol that is best for your individual puppy or kennel, taking into consideration your individual situation.

A possible vaccination schedule for the 'average' puppy is shown below.

Puppy Vaccination Schedule

Age

Vaccination

5 weeks

Parvovirus: for puppies at high risk of exposure to parvo, some veterinarians recommend vaccinating at 5 weeks. Check with your veterinarian.

6 & 9 weeks

Combination vaccine* without leptospirosis. Coronavirus: where coronavirus is a concern.

12 weeks or older

Rabies: Given by your local veterinarian (age at vaccination may vary according to local law).

12-16 weeks**

Combination vaccineLeptospirosis: include leptosporosis in the combination vaccine where leptospirosis is a concern, or if traveling to an area where it occurs. Coronavirus: where coronavirus is a concern. Lyme: where Lyme disease is a concern or if traveling to an area where it occurs.

Adult (boosters)§

Combination vaccineLeptospirosis: include leptospirosis in the combination vaccine where leptospirosis is a concern, or if traveling to an area where it occurs. Coronavirus: where coronavirus is a concern. Lyme: where Lyme disease is a concern or if traveling to an area where it occurs. Rabies: Given by your local veterinarian (time interval between vaccinations may vary according to local law).

*A combination vaccine, often called a 5-way vaccine, usually includes adenovirus cough and hepatitis, distemper, parainfluenza, and parvovirus. Some combination vaccines may also include leptospirosis (7-way vaccines) and/or coronavirus. The inclusion of either canine adenovirus-1 or adenovirus-2 in a vaccine will protect against both adenovirus cough and hepatitis; adenovirus-2 is highly preferred.

**Some puppies may need additional vaccinations against parvovirus after 15 weeks of age. Consult with your local veterinarian.

Vaccines do not stimulate immunity immediately after they are administered. Once a vaccine is administered, the antigens must be recognized, responded to, and remembered by the immune system. In most puppies, disease protection does not begin until five days post vaccination. Full protection from a vaccine usually takes up to fourteen days.

Why do some vaccinated animals still get the disease?

It is a fact that literally hundreds and perhaps thousands of vaccinated dogs are still contracting the diseases they were vaccinated against. Some term this 'vaccine failure,' although it is more likely a failure of the immune system to respond than a problem with the vaccine itself.

Parvovirus is a serious case in point. How can a puppy get the disease and possibly die if it was vaccinated? Unfortunately, for some reason the vaccine did not stimulate the immune system enough to protect the puppy from disease. The reason may be interfering maternal antibodies, the vaccines themselves, the dog's own immune system, or genetics. By far, the most common reason in puppies is interfering maternal antibodies.