The purpose of this study was to determine whether a superficial cold application applied prior to and during intermittent maximal isokinetic exercise would affect the vasodilatory response in the plantar-flexor muscles of the calf. Fourteen healthy, uninjured male subjects, of college age, participated in 4 randomized treatments applied on separate days: Control (CO), Ice Pack only (I), Exercise only (EX), and Ice and Exercise (IEX). Ice packs (I) were applied for 23 minutes, Exercise consisted of 5 bouts of resisted plantar-flexion on an isokinetic device, the Cybex. During IEX, an ice pack was applied 10 minutes prior to exercise and between each exercise bout. Heart rate (HR) was measured by ECG. Blood pressure was measured by auscultation and used to calculate mean arterial pressure (MAP). Total calf blood flow (Q) was estimated by impedance plethysmography. Skin temperature (Tsk), HR, MAP, and Q were compared over 3-minute intervals by two-way MANOVA (p $\le$ 0.01) for time and treatments or independent variables. The measurements were also compared individually over time by a repeated measures procedure (p $\le$ 0.01. A priori comparisons far significant effects were made by Dunn's procedure (alpha $