FORM 8.3 - SHIRE PLC

A PERSON WITH INTERESTS IN RELEVANT SECURITIES REPRESENTING 1% OR MORE

Rule 8.3 of the Takeover Code (the “Code”)

1. KEY INFORMATION

(a)

Full name of discloser:

Barclays PLC.

(b)

Owner or controller of interest and short

positions disclosed, if different from 1(a):

(c)

Name of offeror/offeree in relation to whose

SHIRE PLC

relevant securities this form relates:

(d)

If an exempt fund manager connected with an

offeror/offeree, state this and specify identity of

offeror/offeree:

(e)

Date position held/dealing undertaken:

13 June 2018

(f)

In addition to the company in 1(c) above, is the discloser making

YES:

disclosures in respect of any other party to the offer?

TAKEDA PHARMACEUTICAL CO LTD

2. POSITIONS OF THE PERSON MAKING THE DISCLOSURE

If there are positions or rights to subscribe to disclose in more
than one class of relevant securities of the offeror or offeree named in
1(c), copy table 2(a) or (b) (as appropriate) for each additional class
of relevant security.

(a) Interests and short positions in the relevant securities of the
offeror or offeree to which the disclosure relates following the dealing
(if any)

Class of relevant security:

5p ordinary

Interests

Short Positions

Number

(%)

Number

(%)

(1)

Relevant securities owned

and/or controlled:

9,335,604

1.02%

3,922,130

0.43%

(2)

Cash-settled derivatives:

267,578

0.03%

4,904,017

0.54%

(3)

Stock-settled derivatives (including options)

and agreements to purchase/sell:

424,300

0.05%

573,300

0.06%

(4)

TOTAL:

10,027,482

1.10%

9,399,447

1.03%

All interests and all short positions should be disclosed.

Details of any open stock-settled derivative positions (including
traded options), or agreements to purchase or sell relevant securities,
should be given on a Supplemental Form 8 (Open Positions).

(b) Rights to subscribe for new securities (including directors’ and
other employee options)

Class of relevant security in relation to which subscription right
exists:

Details, including nature of the rights concerned and relevant
percentages:

3. DEALINGS (IF ANY) BY THE PERSON MAKING THE DISCLOSURE

Where there have been dealings in more than one class of relevant
securities of the offeror or offeree named in 1(c), copy table 3(a),
(b), (c) or (d) (as appropriate) for each additional class of relevant
security dealt in.

The currency of all prices and other monetary amounts should be
stated.

(a) Purchases and sales

Class of relevant

Purchase/sale

Number of

Price per unit

security

securities

ADR

Purchase

12

161.4100 USD

ADR

Purchase

46

161.9000 USD

5p ordinary

Purchase

73

40.2725 GBP

5p ordinary

Purchase

73

40.3200 GBP

ADR

Purchase

79

161.5207 USD

ADR

Purchase

100

161.6065 USD

ADR

Purchase

100

161.0099 USD

ADR

Purchase

100

161.5839 USD

5p ordinary

Purchase

129

40.2497 GBP

5p ordinary

Purchase

234

40.2864 GBP

5p ordinary

Purchase

466

40.2506 GBP

5p ordinary

Purchase

484

40.2655 GBP

5p ordinary

Purchase

530

40.2866 GBP

5p ordinary

Purchase

556

40.2522 GBP

5p ordinary

Purchase

620

40.3356 GBP

ADR

Purchase

700

161.4771 USD

ADR

Purchase

874

161.6533 USD

ADR

Purchase

1,065

161.5716 USD

ADR

Purchase

1,074

161.6229 USD

ADR

Purchase

1,100

161.5215 USD

5p ordinary

Purchase

1,246

40.2976 GBP

ADR

Purchase

1,300

161.5027 USD

5p ordinary

Purchase

1,560

40.2798 GBP

5p ordinary

Purchase

1,678

40.3442 GBP

ADR

Purchase

1,800

161.4475 USD

5p ordinary

Purchase

1,887

40.2678 GBP

ADR

Purchase

1,900

161.4442 USD

5p ordinary

Purchase

1,920

40.3176 GBP

5p ordinary

Purchase

2,418

40.2899 GBP

ADR

Purchase

2,450

161.4544 USD

5p ordinary

Purchase

2,496

40.3067 GBP

ADR

Purchase

2,936

161.3100 USD

5p ordinary

Purchase

4,033

40.2622 GBP

5p ordinary

Purchase

4,614

40.2822 GBP

ADR

Purchase

5,300

161.4303 USD

ADR

Purchase

7,595

161.4551 USD

5p ordinary

Purchase

11,000

40.1877 GBP

5p ordinary

Purchase

12,287

40.3035 GBP

5p ordinary

Purchase

15,208

40.2855 GBP

5p ordinary

Purchase

25,062

40.2500 GBP

5p ordinary

Purchase

29,906

40.2882 GBP

5p ordinary

Purchase

36,565

40.2505 GBP

5p ordinary

Purchase

40,000

40.3015 GBP

5p ordinary

Purchase

40,877

40.2763 GBP

ADR

Sale

12

161.4100 USD

5p ordinary

Sale

29

40.2519 GBP

ADR

Sale

46

161.9000 USD

ADR

Sale

50

161.2000 USD

5p ordinary

Sale

62

40.1350 GBP

5p ordinary

Sale

66

40.1375 GBP

5p ordinary

Sale

73

40.3200 GBP

5p ordinary

Sale

74

40.1960 GBP

5p ordinary

Sale

76

40.2700 GBP

ADR

Sale

100

161.5800 USD

ADR

Sale

100

161.6900 USD

ADR

Sale

100

161.6300 USD

ADR

Sale

100

160.9050 USD

ADR

Sale

100

160.9500 USD

ADR

Sale

100

160.9650 USD

ADR

Sale

100

161.3850 USD

5p ordinary

Sale

170

40.2052 GBP

ADR

Sale

191

161.5287 USD

ADR

Sale

200

161.4500 USD

ADR

Sale

200

161.5550 USD

ADR

Sale

200

161.3350 USD

ADR

Sale

210

161.3933 USD

ADR

Sale

290

161.3400 USD

5p ordinary

Sale

294

40.2851 GBP

ADR

Sale

400

161.4350 USD

ADR

Sale

400

161.4175 USD

5p ordinary

Sale

659

40.2820 GBP

ADR

Sale

874

161.6533 USD

ADR

Sale

900

161.3766 USD

ADR

Sale

1,074

161.6229 USD

5p ordinary

Sale

1,186

40.2505 GBP

5p ordinary

Sale

1,210

40.2083 GBP

ADR

Sale

1,300

161.5161 USD

ADR

Sale

1,400

161.4510 USD

5p ordinary

Sale

1,510

40.2114 GBP

ADR

Sale

1,559

161.5067 USD

ADR

Sale

1,700

161.1994 USD

5p ordinary

Sale

2,199

40.2025 GBP

5p ordinary

Sale

2,711

40.3051 GBP

5p ordinary

Sale

3,123

40.2671 GBP

ADR

Sale

3,310

161.3100 USD

5p ordinary

Sale

3,641

40.2581 GBP

5p ordinary

Sale

3,667

40.2744 GBP

5p ordinary

Sale

4,614

40.2822 GBP

5p ordinary

Sale

5,177

40.2768 GBP

ADR

Sale

5,300

161.4303 USD

ADR

Sale

7,000

161.4482 USD

5p ordinary

Sale

7,440

40.2979 GBP

5p ordinary

Sale

8,092

40.3020 GBP

ADR

Sale

8,739

161.4679 USD

ADR

Sale

11,076

161.4376 USD

5p ordinary

Sale

14,904

40.2850 GBP

5p ordinary

Sale

22,005

40.2735 GBP

5p ordinary

Sale

22,398

40.3004 GBP

5p ordinary

Sale

30,913

40.2518 GBP

5p ordinary

Sale

35,967

40.2388 GBP

5p ordinary

Sale

45,548

40.2664 GBP

5p ordinary

Sale

137,919

40.2140 GBP

5p ordinary

Sale

241,360

40.2391 GBP

(b) Cash-settled derivative transactions

Class of

Product

Nature of dealing

Number of

Price per

relevant

description

reference

unit

security

securities

5p ordinary

SWAP

Long

4

40.2475 GBP

5p ordinary

CFD

Long

29

40.2520 GBP

5p ordinary

CFD

Long

170

40.2052 GBP

5p ordinary

SWAP

Long

214

40.3315 GBP

5p ordinary

CFD

Long

294

40.2851 GBP

5p ordinary

CFD

Long

300

40.2768 GBP

5p ordinary

SWAP

Long

328

40.2735 GBP

5p ordinary

SWAP

Long

1,000

40.2459 GBP

5p ordinary

SWAP

Long

1,035

40.2450 GBP

5p ordinary

SWAP

Long

2,925

40.2688 GBP

5p ordinary

CFD

Long

3,641

40.2580 GBP

5p ordinary

SWAP

Long

4,152

40.1904 GBP

5p ordinary

SWAP

Long

16,120

40.2369 GBP

5p ordinary

SWAP

Long

51,720

40.2392 GBP

5p ordinary

SWAP

Long

120,680

40.2391 GBP

5p ordinary

SWAP

Long

137,919

40.2140 GBP

5p ordinary

CFD

Short

10

40.2860 GBP

5p ordinary

SWAP

Short

41

40.2151 GBP

5p ordinary

CFD

Short

41

40.2863 GBP

5p ordinary

SWAP

Short

126

40.2597 GBP

5p ordinary

CFD

Short

183

40.2864 GBP

5p ordinary

SWAP

Short

324

40.2927 GBP

5p ordinary

SWAP

Short

343

40.2479 GBP

5p ordinary

CFD

Short

530

40.2866 GBP

5p ordinary

SWAP

Short

581

40.2806 GBP

5p ordinary

CFD

Short

1,560

40.2798 GBP

5p ordinary

CFD

Short

1,678

40.3442 GBP

5p ordinary

CFD

Short

2,496

40.3067 GBP

5p ordinary

CFD

Short

5,289

40.2787 GBP

5p ordinary

SWAP

Short

9,696

40.2500 GBP

5p ordinary

CFD

Short

11,264

40.3305 GBP

5p ordinary

SWAP

Short

13,604

40.3037 GBP

5p ordinary

SWAP

Short

15,318

40.2624 GBP

(c) Stock-settled derivative transactions (including options)

(i) Writing, selling, purchasing or varying

Class

Product

Writing,

Number

Exercise

Type

Expiry

Option

of

description

purchasing,

of

price

date

money

relevant

selling,

securities

per unit

paid/

security

varying etc

to which

received

option

per unit

relates

ORD

Call Options

Purchasing

7,500

165 USD

American

15 Jun 2018

0.2500 USD

ORD

Put Options

Purchasing

2,000

163 USD

American

15 Jun 2018

1.6500 USD

(ii) Exercise

Class of relevant security

Product description

e.g. call option

Exercising/ exercised against

Number of securities

Exercise price per unit

(d) Other dealings (including subscribing for new securities)

Class of relevant security

Nature of dealing

e.g. subscription, conversion

Details

Price per unit (if applicable)

4. OTHER INFORMATION

(a) Indemnity and other dealing arrangements

Details of any indemnity or option arrangement, or any agreement or
understanding, formal or informal, relating to relevant securities
which may be an inducement to deal or refrain from dealing entered
into by the person making the disclosure and any party to the offer
or any person acting in concert with a party to the offer:

Irrevocable commitments and letters of intent should not be
included. If there are no such agreements, arrangements or
understandings, state “none”

None

(b) Agreements, arrangements or understandings relating to options or
derivatives

Details of any agreement, arrangement or understanding, formal or
informal, between the person making the disclosure and any other
person relating to:

(i) the voting rights of any relevant securities under any option;
or

(ii) the voting rights or future acquisition or disposal of any
relevant securities to which any derivative is referenced:

If there are no such agreements, arrangements or
understandings, state “none”

None

(c) Attachments

Is a Supplemental Form 8 (Open Positions) attached?

YES

Date of disclosure:

14 Jun 2018

Contact name:

Jay Supaya

Telephone number:

020 7773 0635

Public disclosures under Rule 8 of the Code must be made to a
Regulatory Information Service.

The Panel’s Market Surveillance Unit is available for consultation in
relation to the Code’s disclosure requirements on +44 (0)20 7638 0129.