Have low levels of protein C or S, which can increase the risk of having blood clots

Are taking certain herbals that thin the blood, such as St. John's wort or ginseng

Are taking Aptivus (tipranavir)

Pregnancy and Premarin

Pregnant women should not take Premarin because it's known to cause birth defects to your unborn baby

Breastfeeding mothers should not take this medication because Premarin passes into breast milk.

It may also make it more difficult to breastfeed because it decreases the production of breast milk.

Premarin and Horses

The name "Premarin" is short for Pregnant Mares Urine, which is where the drug's active ingredient comes from.

The fact that the hormones used in Premarin are derived from the urine of pregnant horses has become a topic of debate among animal rights' activists.

Premarin Coupons and Prices

Looking to save money on a prescription for Premarin? SingleCare, a leading online service for prescription, dental, and vision discounts, has partnered with most major pharmacies around the country to help you save up to 80 percent off prescription costs. Click on "Free Coupon" below and sign up to get your free SingleCare pharmacy savings card. You'll receive a coupon by email or text to get the best price at a local participating pharmacy near you.

Premarin Interactions

It's always important to share with your doctor and pharmacist all of the medications you are taking.

This includes prescription and over-the-counter medications, supplements like vitamins and other dietary supplements (nutritional shakes, protein powders, etc.), herbals, and any illegal or recreational drugs.

You should not take Premarin if you are taking Lysteda or Cyklokapron (tranexamic acid).

Other medications that have serious interactions with Premarin include:

Premarin and Alcohol

Premarin and Grapefruit Juice

You should avoid eating grapefruit and drinking grapefruit juice while taking Premarin.

Grapefruit juice may make it harder for the body to break down Premarin as quickly as it normally would, which could cause Premarin levels in the blood to rise dangerously high and worsen side effects.

Premarin FAQ

Q: I am 43 and had a complete hysterectomy a little over 2 years ago. Does the hormone Premarin help contribute to weight gain, or could it help with weight loss? It is depressing how much weight I have gained since menopause.

Q: I take Depakote 500 mg 3 times a day and Premarin .0625mg. Do these have anything to do with my weight gain? Can I stop taking Premarin if I've had a full hysterectomy?

A: Depakote was found to cause weight gain in 9 percent of patients taking the medication in clinical studies. Premarin is not usually the cause of weight gain in patients. Patients taking Premarin should be taken for the shortest amount of time at the lowest dose in order to achieve their individual goals. Patients should be re-evaluated every 3 to 6 months to determine if treatment is still necessary.

Q: Is there a cheaper replacement for Premarin, which is so expensive? I am currently taking 0.3mg, but I am trying to wean off of it completely. A 30 day supply right now costs me $54.

A: Patients often inquire about cheaper alternatives to the current treatment that has been prescribed. Firstly, you may want to contact your insurance company, prior to speaking with your doctor, and request a formulary. A formulary is a list of the medications they prefer and the different levels of coverage specific to your plan. Then it is important to contact your health care provider and based on your individual needs and the formulary list of covered medications, the best treatment option can be determined. Beth Isaac, PharmD

Q: What is the best treatment for vaginal dryness? My doctor prescribed Premarin vaginal cream, but I am afraid of the estrogen causing breast or uterine cancer.

A: For women who still have a uterus, who have not had a hysterectomy, taking Premarin alone, without a progestin, increases the risk of endometrial cancer, which is cancer of the lining of the uterus. Women, who still have a uterus, should take Premarin in combination with a progestin. You can take the progestins separately while using the cream. Estrogen drugs, such as Premarin, used with or without a progestin may increase the risk of breast cancer. Proper screening and monitoring, as determined by your healthcare provider, such as yearly mammograms and monthly self breast exams, is recommended. Some studies have shown an increase in ovarian cancer while others have not. You should discuss this with your healthcare provider. For more information: //www.everydayhealth.com/vaginal-dryness/guide/ Gerry Levy, RPh

Q: I had a hysterectomy about ten years ago, am taking Premarin and have not had any problems. What are the benefits and risks of this drug?

A: The benefit of taking Premarin is that it is supplying your body with the hormone estrogen, which was likely greatly lowered after your hysterectomy. Estrogen supplementation has been shown to help with menopausal symptoms such as hot flashes, vaginal dryness, burning, irritation and prevention of osteoporosis. However, hormone replacement can also have risks associated with it. According to the U.S. Food and Drug Administration (FDA), risks that are associated with hormone replacement include increase risk of blood clots, strokes, heart attacks, gall bladder disease and breast cancer. For more FDA information regarding menopause and hormones, which will provide you with valuable information about the benefits and risks associated with hormone therapy: //www.fda.gov/ForConsumers/ByAudience/ForWomen/ucm118624.htm As always, talk with your physician regarding questions about your medications. For additional information regarding menopause: //www.everydayhealth.com/womens-health/menopause-articles.aspx Jen Marsico, RPh www.fda.gov/May 26, 2010.

Q: Is it harmful to take Premarin for a long period of time?

A: Your question regards Premarin (conjugated estrogens) and safety. According to Lexi-Comp, Premarin has a warning that states that estrogens should be used for the shortest duration possible at the lowest effective dosage as possible. You should have received information regarding the risks associated with estrogen replacement from your physician and/or pharmacist. Women are encouraged to weigh the risks associated with hormone treatment to the benefits of treatment. If you have not received information about the risks associated with hormone treatment, please ask your pharmacist for this information. Please talk with your health care provider regarding your concerns. Jen Marsico RPh

Q: I have been on Premarin for over 10 years since my total hysterectomy. It is expensive and I want to get off it. I started taking it every other day. I have heard a lot of bad things about taking Premarin. Is it alright to wean myself off or should I just stop taking it?

Q: How long can you use Premarin? I'm on Premarin for about eight years now.

A: According to the Food and Drug Administraiton, estrogens and progestins should be used at the lowest doses for the shortest duration to reach treatment goals. Women should talk to their health care provider regularly about whether treatment is still needed. There are many long-term side effects that have been associated with hormone therapy. Among those are cancer (breast, ovarian), heart attack, stroke, and blood clots. It is best to consult with your physician to see if you can decrease the dose or possibly stop taking the medication. He or she will know whether the risks outweigh the benefits for your particular situation. For more information on Premarin, click on this link: //www.everydayhealth.com/drugs/premarin Lori Mendoza, PharmD Poulin, PharmD

Q: Is there an over-the-counter medicine similar to Premarin?

A: Premarin (conjugated estrogens) is a mixture of female hormones that works by replacing natural estrogens that women no longer produce. Estrogen is indicated for treatment of menopausal symptoms such as hot flashes, vaginal dryness, and burning. (//www.everydayhealth.com/drugs/premarin) Some over-the-counter products available include Estroven and black cohosh. Estroven is a dietary supplement that contains phytoestrogens. Phytoestrogens are found naturally plants including soybeans, whole grain cereals, seeds, and nuts. Phytoestrogens have a structure similar to that of estrogen produced in the body and help support hormonal balance. Black cohosh is a also a dietary supplement that is a rich herbal source of natural phytoestrogens that has been clinically shown to reduce hot flashes. Soy is also found in many over-the-counter products used to treat menopause. There are actually numerous products available over-the-counter that are marketed to treat the symptoms of menopause. However, it is best to consult with your doctor before taking any of them. Because dietary supplements have not been thoroughly studied in the clinical setting, possible side effects and interactions with other drugs are not well known. Also because herbs and supplements are not strictly regulated in the U.S. Food and Drug Administration, these products are not required to be tested for effectiveness, purity, and safety. In general, dietary supplements should only be taken under the supervision of your health care provider. For more specific information, consult with your pharmacist about the potential for drug interactions based on your specific condition and current medications, particularly before taking any action. When your doctor prescribes a new medication, be sure to discuss all your medications and over-the-counter drugs, including dietary supplements, vitamins, botanicals, minerals and herbals, as well as the foods you eat. Also keep a current list of the drugs and supplements you take and review it with your health care provider and your pharmacist. If possible, use one pharmacy for all your prescription medications and over-the-counter products. This allows your pharmacist to keep a complete record of all your prescription drugs and to advise you about drug interactions and side effects. Kimberly Hotz, PharmD.

Q: http://Can burning in the breast be caused by taking a low dose of Premarin tablets for more than 10 years? Is this a sign of breast cancer?

A: Estrogen is a female sex hormone that is produced by the ovaries and is necessary for many processes in the body. Premarin (conjugated estrogens) is a mixture of estrogen hormones used to treat symptoms of menopause such as hot flashes, and vaginal dryness, burning, and irritation. It can also be used to prevent osteoporosis in postmenopausal women and to replace estrogen in women with ovarian failure or other conditions that cause a lack of natural estrogen in the body. Breast pain, tenderness, or swelling can be a common side effect of Premarin. A search of the prescribing information for Premarin did not list burning in the breast as a specific side effect. Other common side effects include mild nausea, vomiting, bloating, stomach cramps, darkening of facial skin, increased hair growth, loss of scalp hair, changes in weight or appetite, decreased sex drive, headache, nervousness, dizziness, and tiredness. This is not a complete list of side effects that can occur with Premarin. If you are concerned about a particular side effect or symptom you are experiencing, please consult your doctor. Your doctor or health care provider is best able to properly evaluate your medical condition and make recommendations based on your specific circumstances. You may also get more information by using the Everyday Health Symptom Checker. Sarah Lewis, PharmD

Q: I've been taking Premarin for a long time. Is it harmful to take it for long periods?

A: Premarin carries a warning that estrogens should be used for the shortest duration possible, at the lowest effective dosage possible. You should have received information regarding the risks associated with estrogen replacement from your physician and/or pharmacist. Women are encouraged to weigh the risks associated with hormone treatment against the benefits of the treatment. If you have not received information about the risks associated with hormone treatment, please ask your pharmacist for this information. Also talk with your health care provider about your concerns regarding Premarin. Jen Marsico, RPh

Q: When using Premarin vaginal cream, I started to lose a lot of scalp hair. I want to know if I stop using the Premarin cream if the hair will grow back?

A: Premarin Vaginal Cream (conjugated estrogen) (//www.everydayhealth.com/drugs/conjugated-estrogens-topical) is a mixture of estrogen hormones that work by replacing natural estrogens that the body no longer produces. Premarin Cream treats vaginal dryness and painful intercourse caused by vaginal changes. (//www.everydayhealth.com/womens-health/womens-health-articles.aspx). Premarin Cream can be absorbed into the bloodstream, but side effects may not be as severe as taking oral Premarin. Common side effects of Premarin Cream are breast tenderness, vaginal burning, itching or irritation, and weight changes. Another side effect of Premarin Cream listed was mild hair loss. This is not a complete list of the side effects associated with Premarin Cream. For more specific information, consult with your doctor or pharmacist for guidance based on your health status and current medications, particularly before taking any action. When your doctor prescribes a new medication, be sure to discuss all your prescription and over-the-counter drugs, including dietary supplements, vitamins, botanicals, minerals, and herbals, as well as the foods you eat. Always keep a current list of the drugs and supplements you take and review it with your health care providers and your pharmacist. If possible, use one pharmacy for all your prescription medications and over-the-counter products. This allows your pharmacist to keep a complete record of all your prescription drugs and to advise you about drug interactions and side effects. Tell your health care provider about any negative side effects from prescription drugs. You can also report them to the U.S. Food and Drug Administration by visiting www.fda.gov/medwatch or by calling 1-800-FDA-1088. Kimberly Hotz,PharmD

Q: What does Premarin do? I was told that my hormones and thyroid are out of whack. I am 48 years old and had a hysterectomy when I was 32. I took Premarin for seven years, but I hear so much about it, I'm confused.

A: Premarin (conjugated estrogens tablets, USP) is used after menopause to reduce moderate to severe hot flashes; to treat moderate to severe dryness, itching, and burning, in and around the vagina; and to help reduce your chances of getting osteoporosis (thin weak bones). The most commonly reported side effects with Premarin include vaginitis due to yeast or other causes, vaginal bleeding, painful menstruation, and leg cramps. When your doctor prescribes a new medication, be sure to discuss all your prescription and over-the-counter drugs, including dietary supplements, vitamins, botanicals, minerals, and herbals, as well as the foods you eat. Always keep a current list of the drugs and supplements you take and review it with your health care providers and your pharmacist. If possible, use one pharmacy for all your prescription medications and over-the-counter products. This allows your pharmacist to keep a complete record of all your prescription drugs and to advise you about drug interactions and side effects. For more specific information, consult with your doctor or pharmacist for guidance based on your health status and current medications, particularly before taking any action. Shereen A. Gharbia, PharmD

Q: I have been on Premarin for 12 years. I have tried to reduce it to one every other day, but it makes me feel awful. What is your advice?

A: Premarin (conjugated estrogens) is in a drug class called hormones. Premarin is used to treat symptoms of menopause, like hot flashes and dryness, and burning and irritation of the vaginal area. Premarin is also used to prevent osteoporosis in women who have gone through menopause. In addition, Premarin is used to replace estrogen in women whose ovaries have failed or in certain other conditions that cause a lack of natural estrogen in the body. Sometimes, Premarin is used in combination with other therapies to treat certain cancers in women and men. Premarin works by replacing estrogen that is normally made by the body. Estrogen is a female sex hormone responsible for many processes in the body. According to Premarin?€™s prescribing information, estrogens should be taken at the lowest possible dose and only as long as needed. A person who takes Premarin should talk to their health care provider on a regular basis (e.g., every 3 to 6 months) about the dose of Premarin being used and whether Premarin treatment is still needed. Derek Dore, PharmD

Q: How long should I take Premarin? What are the side effects?

A: Premarin (estrogen) is a female hormone, used to ease the symptoms of menopause. It can be taken while symptoms are present or until menopause is complete. The amount of time depends on the individual, but it usually lasts an average of 12 months from the last period. It should not be used forever, as there are risks of breast cancer, heart disease, and stroke. Side effects from the medication may include breast pain or tenderness, nausea, vomiting, heartburn, flu or cold symptoms, back pain, vaginal discharge, painful or difficult urination, dizziness, nervousness, depression, irritability, insomnia, hair loss, unwanted hair growth, changes in sexual desire, swelling, redness, burning, itching, or irritation of the vagina, leg cramps, difficulty wearing contact lenses, spotty darkening of the skin on the face, and sudden feelings of heat or sweating. This is not a complete list of the side effects associated with Premarin (estrogen). For more specific information, consult with your doctor or pharmacist for guidance based on your health status and current medications, particularly before taking any action. When your doctor prescribes a new medication, be sure to discuss all your prescription and over-the-counter drugs, including dietary supplements, vitamins, botanicals, minerals, and herbals, as well as the foods you eat. Always keep a current list of the drugs and supplements you take and review it with your health care providers and your pharmacist. If possible, use one pharmacy for all your prescription medications and over-the-counter products. This allows your pharmacist to keep a complete record of all your prescription drugs and to advise you about drug interactions and side effects. Tell your health care provider about any negative side effects from prescription drugs. You can also report them to the U.S. Food and Drug Administration by visiting www.fda.gov/medwatch or by calling 1-800-FDA-1088. For more specific information, consult with your doctor or pharmacist for guidance based on your health status and current medications, particularly before taking any action. Patti Brown, PharmD

Q: What are the side effects of vaginal Premarin?

A: Although the risk of a serious adverse effect is much less likely for most women using low doses of estrogens vaginally compared to orally, adverse effects are possible. Serious adverse effects of estrogen therapy include: breast cancer, cancer of uterus, stroke, heart attack, blood clots, dementia, and gallbladder disease. If you are predisposed to any of the above conditions because of family history, high cholesterol, high blood pressure, tobacco use, or obesity, you are at a higher risk for complications. The most common side effects of vaginal Premarin therapy are back pain; bloating; breast pain; depression; diarrhea; dizziness; flu syndrome; gas; hair loss; headache; cough; indigestion; infection; irregular vaginal bleeding or spotting; itching; joint pain; lightheadedness; leg cramps; muscle aches; nausea; nervousness; pain; runny nose; sinus inflammation; sleeplessness; sore throat; stomach pain; upper respiratory tract infection; vaginal inflammation; weakness; and weight changes The risks of serious adverse effects due to vaginal estrogen therapy have to be weighed against the benefits. You should regularly check your breasts for any unusual lumps or discharge, and have a mammogram and pap smear done based on your physicians recommendations. If you would like to submit another question, return to Everyday Health. For more information on menopause and vaginal dryness, click here. Burton Dunaway, PharmD.

Q: Can Premarin 0.3 mg tablets be cut in half to create a half dose? I am trying to wean myself off of hormone replacement therapy.

A: It is not recommended to cut these tablets in half. You may want to try an alternate day dosing schedule. As always, check with your physician before making any changes to your current medication regimen. Joseph Hall, RPh

Q: I have been on Premarin .625 for a couple of years. My mid-section has really increased. Does this med make you gain weight? I do exercise daily.

A: According to the package insert for Premarin, weight gain is listed as a potential side effect of Premarin therapy. It is important to report any side effects you are experiencing to your health care provider. This information is solely educational. It's important to consult with your physician or health care provider about any specific questions regarding your medical conditions or medications; particularly before taking any action. You can also find helpful information at //www.everydayhealth.com/womens-health/womens-health-articles.aspx and //www.everydayhealth.com/weight/facts-about-calories.aspx. Kristen Dore, PharmD

Q: I have taken Premarin for the last five years. When do I need to stop taking this medication? I've taken it for so long. Are there any long-term side effects?

A: Over the course of a female's lifetime, the levels of estrogen and progesterone in the body begin to decrease. Once these levels decrease enough, menopause sets in. Some of the biggest complaints about menopause are hot flashes and vaginal dryness. Premarin (conjugated estrogens) is a mixture of estrogen hormones that are used to treat symptoms of menopause. Premarin is used to treat hot flashes, vaginal dryness, burning, and irritation. Some of the more-common side effects of Premarin are vaginal spotting, breast tenderness, cramps, nausea, headache, fluid retention, elevated blood pressure, and mood changes. There are currently no recommendations as to how long a person should be on Premarin therapy. It is recommended to speak with your doctor regarding your concerns about taking this medication. If you feel like this medication is no longer providing you with any benefits, be sure to ask your doctor whether this medication is still right for you. For more specific information, consult with your doctor or pharmacist for guidance based on your health status and current medications, particularly before taking any action. Megan Uehara, PharmD

Q: I'm overweight, 52, in menopause, and have type 2 diabetes. My doctor has prescribed Premarin for me. I'm a little worried about strokes, heart problems, and cancer if I use this product. My doc gave it to me for painful intercourse and thinning vaginal walls. Do I need to worry about using Premarin? I do not have hot flashes anymore.

A: Over the course of a female's lifetime, the levels of estrogen and progesterone in the body begin to decrease. Once these levels decrease enough, menopause sets in. Some of the biggest complaints about menopause are hot flashes and vaginal dryness. Hormone therapy helps reduce menopausal symptoms and decreases the risk of osteoporosis. However, it has been associated with some cancers. Lung cancer risk may be increased by using estrogen and progestin, especially when used for 10 or more years. Breast cancer risk may increase three or more years. However, this risk is very small and declines after stopping therapy for two to three years. Endometrial cancer risk is much higher for women taking estrogen therapy alone. Thus, it is recommended to take estrogen and progestin in combination. Based on these findings, it is recommended to use hormone therapy with caution and for the shortest amount of time possible. It is best to speak with your doctor regarding the risks and benefits of using hormone therapy. For more specific information, consult with your doctor or pharmacist for guidance based on your health status and current medications, particularly before taking any action. Megan Uehara, PharmD

Q: I have been taking low-dose Premarin for many years. I tried to stop, but it was horrible. I had my uterus removed at 40. I have my ovaries intact. I am now 58. Will I be okay?

A: Premarin (conjugated estrogens) is a mixture of estrogen hormones used to treat symptoms of menopause such as hot flashes, and vaginal dryness, burning, and irritation. This is known as hormone replacement therapy (HRT). It can also be used to prevent osteoporosis in postmenopausal women and to replace estrogen in women with ovarian failure or other conditions that cause a lack of natural estrogen in the body. The Women's Health Initiative (WHI) is a major study, supported by the National Institutes of Health, of the risks and benefits of hormone replacement therapy (HRT). In general, results from WHI suggest that HRT, including Premarin, should be used at the lowest possible dose for the shortest amount of time. Long-term use of HRT has been associated with an increased risk of heart attack, stroke, breast cancer, and blood clots in women 50 to 79 years of age. In WHI, this risk was seen in women taking HRT for 5 years. Using HRT may also increase the risk of developing dementia. This risk was seen in women 65 years of age or older who had been using HRT for 4 years. If you are concerned about the risks of long-term HRT, talk to your doctor about stopping for specific recommendations. Be aware that menopause symptoms may return if HRT is stopped. Symptoms may take up to 12 weeks to reappear and the ones that are most likely to return are hot flashes, night sweats, and sleep disturbances. However, they are likely to be milder than before starting HRT. Your doctor is best able to guide your treatment decisions based on your specific circumstances. Consult your health care provider before stopping HRT. For more specific information, consult with your doctor or local pharmacist for guidance based on your health status and current medications, particularly before taking any action. Sarah Lewis, RPh, PharmD

Q: My doctor gave me a prescription for Premarin vaginal cream. However, my sister has had breast cancer, and I had melanoma on my leg. My dad had esophageal cancer. Am I foolish to try premarin, or should I consider other options? I was looking at that Cream de la Femme. What are your thoughts on this?

A: Premarin vaginal cream is an estrogen replacement medication used for hormone replacement therapy during menopause. There are risks and warnings associated with using hormone replacement medications. If you are unaware of the risks and warnings, please talk with your health care provider for written information concerning hormone replacement therapy. Click here to read an article on Everyday Health regarding information that women should know when considering using hormone replacement medications. //www.everydayhealth.com/menopause/about-hormone-replacement.aspx According to the article, women who should not use hormone replacement therapy are women who have breast cancer, heart disease, liver disease, a history of blood clots or women who are not having symptoms of menopause. Creme de la femme is not a Food and Drug Administration-approved medication. This means that the extensive testing that is performed on FDA-approved products including but not limited to safety, side effects, drug interactions, disease state issues, etc. has not been performed on products that are not FDA approved. Therefore, it is impossible to comment on the efficacy and safety of this product. As always, talk with your health care provider regarding your concerns about using Premarin vaginal cream and ask your health care provider if Cream de la femme would be an appropriate therapy for you. Click here for additional information provided by Everyday Health regarding menopause. //www.everydayhealth.com/womens-health/menopause-articles.aspx Jen Marsico, RPh

Q: I have been prescribed Premarin (vaginal cream, 1/2 each insertion for 2 wks.; 2x weekly thereafter). I've experienced cramping. Is this normal?

A: Unfortunately, cramping is a noted adverse reaction of Premarin. Usually, this side effect seems to go away with time, so hopefully you will see a decrease in the cramps. If the problem does not seem to go away, speak with your doctor to see if they would recommend another medication or if they want you to take over-the-counter pain medications for the cramps. Megan Uehara, PharmD

Q: I take Premarin and Provera in a low dose for osteopenia. I am happy with it, except for the fact that there is no generic for Premarin. Is there a different brand of conjugated estrogens in a pill form that I could get that has a generic or that would be cheaper? And would it have the same effect on my bones? Does Prometrium protect the uterus as well as Provera?

A: The patent for Premarin (conjugated estrogens), the female hormone used to treat symptoms of menopause, has expired, but there are no U.S. FDA (Food and Drug Administration) approved generics available, and there are no other, less expensive, conjugated estrogens available. You may want to ask your doctor if you can take the estrogen, Estrace (estradiol), as it is very inexpensive, but it is not the exact same estrogen as Premarin (conjugated estrogens). Prometrium (micronized progesterone) and Provera (medroxyprogesterone) are both forms of progesterone, but Prometrium (micronized progesterone) may cost more and is not recommended for people with peanut allergies, beacuse the medication is made with peanut oil. If you are treating osteopenia, you should make sure to take a calcium supplement, along with vitamin D to help it absorb into the bone, and the calcium should only be taken in doses of approximately 500mg at a time, because studies have found that the body does not absorb high doses well. A supplement made by a manufacturer that promotes "standardization" is recommended. In general, dietary supplements should only be taken under the supervision of your health care provider. Patti Brown, PharmD

Q: Since taking Premarin, I've been losing a lot of hair. What are the side effects of taking Premarin?

A: Premarin (conjugated estrogens) is a mixture of estrogen hormones used to treat symptoms of menopause, including hot flashes, and vaginal dryness, burning, and irritation. Premarin is also used to prevent osteoporosis and to replace estrogen in women with ovarian failure or other conditions in which natural estrogen is lacking. According to the package insert, the most common side effects of Premarin are headache, abdominal pain, joint pain, vaginal bleeding, nausea and vomiting, and hair loss. Using estrogens may increase your chance of having a serious cardiovascular event including a heart attack, stroke, or blood clot. Estrogens may also increase the change of getting breast cancer or cancer of the uterus. This is not a complete list of the side effects associated with Premarin. For more specific information, consult with your doctor or pharmacist for guidance based on your health status and current medications, particularly before taking any action. Michelle McDermott, PharmD

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