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Although Sony Pictures didn’t screen the fifth Resident Evil movie for mainstream media, the film had a solid midnight opening with $655,000 (ahead of the $625,000 that Resident Evil: Afterlife 3D earned). Resident Evil: Retribution 3D ruled the box office once again opening weekend, taking in $21.1 million in the U.S. to beat out the 3D remake of Disney/Pixar’s Finding Nemo, which took in $17.7 million.

Director Paul Anderson, who has been involved with all five Screen Gems films, is looking forward to playing Capcom’s Resident Evil 6 game. The much-anticipated game will ship October 2. Anderson said the new game will influence the sixth Resident Evil movie, which the director has already outlined, in the video interview below.

The $65 million Resident Evil: Retribution movie incorporates a large cast of characters and elements from Capcom’s Resident Evil 4 and 5. While many hardcore gamers don’t like the movies, there’s a huge audience out there, especially worldwide, that had catapulted each film to higher box office than the previous edition (domestic openings were $17.7 million, $23 million, $23.7 million, and $26.7 million). The franchise has earned over $696.9 million to date in theaters alone. Afterlife took in $60.1 million in the U.S. but a whopping $236.1 million overseas.

Milla Jovovich, who has played Alice in each film, talks about why Resident Evil has become the most successful videogame franchise of all time in the video interview below. She’d also like to see Alice migrate to a future Capcom game.

One of the key draws for Retribution is the resurrection of past characters who died in previous films. Michelle Rodriguez, who also returned in the Fast and Furious franchise (and will appear in the next two movies), talks about coming back from the dead in the video interview below. Rodriguez is the biggest gamer in the cast of the new film.