"Our findings suggest that thalamic volume and shape abnormalities are evident at the onset of
FES (First-Episode Schizophrenia) prior to thalamic abnormal white matter integrity.
Altered microstructural white matter integrity assessed using DTI may not be apparent in FES
but may be observed as the disease progresses. Cognitive deficits related to spatial working memory
and executive functioning in FES were observed in the context of loss of their normal relationship
with the thalamic shapes (...)"
S

"Patients with chronic schizophrenia perform poorly on behavioral and neuropsychological
tasks related to OFC functions. (...) This finding suggests that the OFC function, as measured
by decision-making tasks, is preserved in the early phases of schizophrenia."
S

"DLPFC dysfunction may be related to the genetic risk for schizophrenia
as both patients and their unaffected relatives show reduced activity in this region."
S

During a parametric verbal working memory task, activation in the (DLPFC)
increased in controls as performance decreased, while patients showed the opposite.
Overall, low performing patients were hypoactive and high performing patients hyperactive
relative to controls.
S

P-SCZ individuals (paranoid individuals with schizophrenia) showed significantly reduced neural
activation in the left VLPFC as compared to controls
and in the left VLPFC as compared to NP-SCZ individuals while rating faces for trustworthiness.
S

"Abnormal amygdala activation in schizophrenia in response to presentation of fearful faces
is paradoxically associated with failure to recognize the emotion and with more severe flat affect."
S

"The schizophrenia patients without an AI (adhesio interthalamica) had a smaller
bilateral amygdala than those with an AI, whereas the AI was not associated with the volume
of the amygdala in the control subjects. These findings suggest that the absence of AI
in schizophrenia could be a marker of developmental abnormalities in the neural network
including the thalamus and connected amygdaloid regions, which may play an important role
in the pathogenesis of schizophrenia."
S

"Our results are in line with previous reports about dysfunctional ACC activation
in schizophrenia and argue in favour of a selective deficit of cortical conflict resolution.
It is further proposed that dysfunctional ACC activation during executive processing may be a
neurophysiologic endophenotype candidate of schizophrenia."
S

"Our findings demonstrate a blunted response to error commission that is associated
with worse performance in two ACC circuits in schizophrenia. In the dACC circuit,
the blunted response may reflect deficient modification of prepotent stimulus-response mappings
in response to errors, and in the rACC network it may reflect diminished concern regarding
behavioural outcomes. However, despite these deficits and in the absence of external feedback
regarding errors, patients corrected their errors as frequently as controls suggesting intact
error recognition and ability to institute corrective action. Impairments in evaluating and
learning from errors in schizophrenia may contribute to behaviour that is rigid and perseverative
rather than optimally guided by outcomes, and may compromise performance across a wide range of tasks."
S

Possible increased acetylcholine and down regulated GABA stimulation in the PCC of schizophrenia
S

"The impaired RS-PCC functionality in a semantic task may relate to verbal memory
deficits frequently observed in schizophrenia patients, because this region is pivotal
for gating information into the medial temporal lobe memory system."
S

"The absence of AI in schizophrenia could be a marker of developmental abnormalities
in the neural network including the thalamus and connected amygdaloid regions, which may play an important
role in the pathogenesis of schizophrenia."
S

"Results suggest that there are no marked changes in fornix volume in schizophrenia by MRI.
The fornix, however, may be part of a network of structures affected in schizophrenia..."
S

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