We use an array of proteomic, biochemical and cell biology techniques to study neurodegenerative diseases, particularly amyotrophic lateral sclerosis (ALS, Lou Gehrig’s disease). We are interested in understanding protein degradation and aggregation, oxidative stress, mitochondrial dysfunction and axonal transport in ALS and other neurodegenerative diseases.

Developing innovative proteomic methodologies to enable quantitative analysis of proteins and protein modifications is another interest of the laboratory. Moreover, we have been collaborating to apply proteomic approaches to multiple biomedical fields, including prostate cancer, diabetes and environmental toxicology.

Zhou, P.;Wei, R.;Guo, Z.;Zhu, H.;Campbell, D.;Li, Q.;Xu, X.;Wang, J.;Luan, M.;Chen, X.;Chen, G."A Single Nucleotide Variant in HNF-1β is Associated with Maturity-Onset Diabetes of the Young in a Large Chinese Family."Iranian journal of public health45,2(2016):170-8.[PubMed Link] |

Yang, L.;Gal, J.;Chen, J.;Zhu, H."Self-assembled FUS binds active chromatin and regulates gene transcription."Proceedings of the National Academy of Sciences of the United States of America111,50(2014):17809-14.[PubMed Link] | [ Full text ]

Dubal, D.B.;Zhu, H.;Yu, J.;Rau, S.W.;Shughrue, P.J.;Merchenthaler, I.;Kindy, M.S.;Wise, P.M."Estrogen receptor alpha, not beta, is a critical link in estradiol-mediated protection against brain injury."Proceedings of the National Academy of Sciences of the United States of America98,4(2001):1952-7.[PubMed Link] | [ Full text ]