Tonic-clonic transitions in a seizure simulation (Lytton and Omurtag 2007)

"... The authors have ... computationally manageable networks of moderate size consisting of 1,000 to 3,000 neurons with multiple intrinsic
and synaptic properties.
Experiments on these simulations demonstrated the presence of epileptiform behavior in the form of
repetitive high-intensity population events (clonic behavior) or
latch-up with near maximal activity (tonic behavior).
...
Several simulations revealed the importance of random coincident inputs to shift a network from
a low-activation to a high-activation epileptiform state. Finally, a
simulated anticonvulsant acting on excitability tended to preferentially
decrease tonic activity."
Reference: 1 .
Lytton WW, Omurtag A (2007) Tonic-clonic transitions in computer simulation. J Clin Neurophysiol24:175-81 [PubMed]

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