PHARMACEUTICAL PRODUCTION

We provide serious quality control to factories that work in the pharmaceutical industry. Our company detects all common problems that might occur during the manufacturing process such as monitoring of crystallization, API stability, yellowing, and other forms of quality degradation, residence time, API’s shear and temperature exposure, etc. Below you can find more details on the technical side of the defined problems, including data that shows you how and when exactly you can discover those issues with our hardware & software solutions installed to your plant. With our extensive portfolio of precise instruments, you can be sure to receive constant and accurate measurements that ensure your compliance with government regulations and product specifications.

Inline measurements can be performed at the first possible moment in the process stream without disturbing the running process, while offline measurements must be performed in the laboratory.

ColVisTec's technology doesn't interfere with the production process; we install our fiber optic probes to the existent hardware already connected at your factory. Our probes can handle substantial distances (up to 20 meters) between the spectroscopy system and your measurement point. One system can be used for two independent production lines at a time. It allows you to continuously measure the manufactured substance every 10 seconds or less directly in the process without sampling, without interrupting the production line, and without delays. This, in turn, maximizes the efficiency of the manufacturing process and minimizes costs at the same time.

REFLECTION POLYMER MELT PROBE (RPMP)

REFLECTION POLYMER MELT PROBE (RPMP)

Probe Tip: Standard Dynisco Thread 1/2”-20 UNF

Sapphire Window (Self Cleaning by Material Flow)

Separate Fiber Optic for Easy Calibration

Temperature: ≤ 350 °C

Pressure: ≤ 200 bar

(1) The RPMP probe installed on (2) the extruder. For example, in the die-plate.

Illumination with Xenon Flash Lamp

Six Circumferential Positioned Glass Fibers for Illumination

Center Positioned Fiber for Reflectance

Standard Fiber Length: 5 m

Maximum Fiber Length: 20 m

APPLICATION USE

RPMP probes are used to measure opaque materials such as molten polymers, chemicals, pharmaceuticals, as well as powders. This probe is specially designed to withstand the high temperature and pressure often found in extruders, though it can also be installed in other types of manufacturing machinery.

INSTALLATION OF THE RPMP PROBE BODY IN EXTRUDER

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1. A free thread 1⁄2“-20 UNF is required
2. Fix the probe body in the thread

3. Place and fix fiber optic in the probe body
4. Probe tip with the sapphire window is ca. 5 mm in the extruder body

SOFTWARE

THE SOFTWARE FOR PRECISE QUALITY CONTROL

Our technology can be customized for a wide variety of processes, offering data output in various formats, and excellent integration with the hardware solutions already in place. Scroll down to read the full technical details of each software package we offer and leverage it to your advantage.

ReTA

ReTA helps to gather a growing bunch of log files with RTM data, extract concentration data from the spectrometric data, discover the RTM segments and their textual descriptions, align the beginnings, synchronize the proceedings, filter out noise, combine selected subsets for averaging, estimate asymptotic behavior, convert the resulting curve into a viable approximation of a probability distribution, display the result, and derive further statistics from that, including estimates of percentile times.

SpecViewer

SpecViewer is a tool designed to display and navigate the sequences of spectra in an intuitive way, presenting both overview and details graphically and assisting analysis by offering common transformations that emphasize relations between spectra. The human-visible color associated with each spectrum is directly visualized by presenting the spectral curve itself in that color.