University of California, San Francisco, Department of Surgery, San Francisco, Calif 94143, USA. azakiet@surgery.ucsf.edu

Abstract

OBJECTIVES:

In the current study we describe and characterize a novel ovine model of biventricular hypertrophy and heart failure and evaluate the role of selected cardiac transcription factors in the regulation of cardiac gene expression during pathologic hypertrophy in vivo. The cardiac troponin T promoter is used as a model gene.