Peyronie's disease is a deformity due to excessive deposition of collagen which causes the penis to bend in a way that makes intercourse difficult, frequently painful, and even impossible in severe cases. Currently, the only proven treatment is surgery which is not widely performed.

Lipomas are benign fatty tumors that occur as bulges under the skin. Since the only proven therapy for lipomas is surgery , collagenase injection represents a potential minimally invasive approach for humans which may be a therapeutic advantage over the current options.