Objective Study in Rheumatoid Arthritis (OSRA)

This study has been completed.

Sponsor:

Sanofi

ClinicalTrials.gov Identifier:

NCT00451971

First Posted: March 26, 2007

Last Update Posted: September 5, 2008

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To test the feasibility, in patients with active rheumatoid arthritis, of using an 'aggressive' treatment algorithm to bring a short term treatment objective (STO) within the normal or an arbitrarily defined 'desirable' range.

To determine whether patients with active rheumatoid arthritis randomly allocated to a particular STO show a reduced rate of Magnetic resonance imaging damage progression at two years compared to those randomly allocated to usual care.

Secondary Objectives

To establish the relationship between achieving a given STO or combination of STOs and damage progression.

To identify the characteristics of responders and non-responders with respect to STO achievement and predictors of greater and lesser degrees of damage progression.