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Windows 7: Win 7 and portable apps dont mix?

I should have prefaced my post above with a more generalized question:
Since I'm starting from ground zero with portable apps for my desktop and my flash drive, would some kind soul lay out the steps they used to set up such an environment? That would be much appreciated because it would save me from googling all over the web and wasting a lot of time.

I'm sure some more knowledgeable members will come along, but I have a 1 Gig usb stick with a number of portable apps on it. It's been a while and I can't remember how I started it, but adding new programs is easy. AS good place to start is Portable Apps

Thank you, A Guy. You've helped me a lot with the sites you mentioned.
To you, or anyone else - does this "plan" of mine make sense; or can you suggest a better one:
I have W7 on a desktop, with 2 separate drives (80 gig and 500 gig), and a 16 gig flash drive.
I want to replace as many/all of my programs that had originally been installed on my OS drive (to reduce/eliminate as many registry entries as possible etc.)
So, I'm planning to set up a master folder on my data drive with portable apps, and run these on my "mainframe."
Then, I'll also set up my flash drive similarly, so I can take that with me to fix family PC problems from.
Does that make sense?

It makes sense, and should work fine. Personally I have plenty of HDD space, and great speed, so feel no need to do a lot of the "speed tweaks". But portable programs work just as good from an internal drive. A Guy

They also run lightning fast on a RAM drive. On my home desktop I run all of my portables from my RAM disk. It spoils me when I run the same programs off my thumb drive. There's no comparison. They open instantly, and run much faster on the RAM drive.

Win 7 and portable apps dont mix?

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