Kamagra: Treatment of erectile dysfunction in men

Price

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Coupons and Discounts

Kamagra (Sildenafil Citrate) – a drug for the treatment of disorders erektsii. Sildenafila citrate is a potent and selective inhibitor of cGMP-specific phosphodiesterase tipa5 (PDE5). The physiological mechanism of erection of the penis involves the release of nitric oxide (NO) in the cavernous body during sexual stimulation.

The preparation at a dose of 100 mg has no effect on locomotor activity and morphology of spermatozoa following a single administration.

The medicament relates to a substantially non-toxic substances. It does not have locally irritant. No teratogenic and embryotoxic action, does not have immunotoxic and sensitizing effect.

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Pharmacological properties

Pharmacokinetics of Kamagra (Sildenafil Citrate) is dose-dependent. After taking the drug inside Sildenafil is rapidly absorbed. Absolute bioavailability on average was 41%. After ingestion fasting max is reached within 30 minutes. When taking sildenafil in combination with fatty food absorption rate decreases; Sildenafil is 96% bound to plasma proteins. Protein binding is not dependent on the total concentration of sildenafil. Kamagra (Sildenafil Citrate)is metabolized in the liver. The main circulating metabolite is further metabolized. The concentration of metabolite in the plasma is about 40% of the concentration of sildenafil.

Indications

Treatment of erectile dysfunction in men.

Dosing and Administration

The drug is taken orally. When fasting effect is faster. The drug is taken about 1 hour before sexual activity.

Use strictly under medical supervision.

Side effects

Very often:

Dizziness

Visual impairment (mild and transient, predominantly lead to a violation of color, as well as increased sensitivity to light or “blurred” vision)

Cautions

It is necessary to study the history and conduct a physical examination to diagnose erectile dysfunction, to identify potential root causes and appropriate treatment. To some extent, there is a risk to the cardiovascular system associated with sexual activity; therefore, the doctor needs to assess the state of the cardiovascular system of patients before prescribing any medications for treating erectile dysfunction.

Preparations for the treatment of erectile dysfunction should be used with caution in patients with anatomical deformation of the penis , or in patients with concomitant diseases, which can cause priapism (such as sickle – cell anemia, multiple myeloma or leukemia).

Safety and efficacy in combination with other drugs for the treatment of erectile dysfunction have not been studied. Therefore, to use the drug in combination with such drugs is not recommended.

Kamagra (Sildenafil Citrate) no effect on bleeding time when receiving the drug alone or along with aspirin. Human platelets showed that the drug enhances the antiplatelet effect nitro cyanide solution (nitric oxide donor). Data on the safety of the drug in patients with disorders of the active form of bleeding or peptic ulcer is not represented. Therefore, the drug should be used with caution in these patients.

Given the side effects of the drug, caution should be exercised when driving or other potentially dangerous machinery.

Overdose

When high doses of the drug may be observed enhancement of side effects observed upon receiving the recommended doses. In case of overdose prescribe general symptomatic and supportive treatment.