Neurogenetics of candidate systems in autism (supplement)

Numerous studies have demonstrated that genes are a major component of the etiology of autism, but these genes remain unidentified. Instead of using whole genome screens, this study develops a set of functional candidate genes based on knowledge of the specific behavioral deficits observed in individuals with autism and what is known about the neurobiology underlying those behaviors. Specifically, genes in the neurotransmitter systems utilizing serotonin and GABA will be analyzed in 600 families. Variations in each gene, called single nucleotide polymorphisms (SNPs), will be characterized, and the effects of interactions between the genes will be examined. This approach could discern the roles of serotonin and GABA genes in autism.