The most important argument against scientific realism is pessimistic meta –induction. One of the main task of scientific realists is to make an effective rebuttal to this argument. In this paper we formulate a form of the argument, then consider the most important rebuttal that make against it, concisely. Our claim is that the structural realism rebuttal is the most acceptable one, but its thesis, which is that what is preserve in the theory change is structure and science just represent the structural relations in the world, must be evaluated by considering scientific theories case by case in all scientific domain, such as physics , biology, chemistry, etc