Despite practicing in a limited capacity throughout the week, Howard failed to be cleared for contact in time for the Week 11 matchup. Second-round rookie Miles Sanders will be heavily featured in his place on Sunday. The team re-signed veteran running back Jay Ajayi on Friday. Ajayi and Boston Scott will back up Sanders in the backfield.

The Eagles will also be without wide receiver Alshon Jeffery (ankle) against New England.

Jeffery injured his ankle during the win over the Bears. He failed to practice throughout Week 11, despite having the entire bye week to rest.

In positive news, left tackle Jason Peters (knee) will play on Sunday. Peters missed three games after undergoing arthroscopic surgery on his knee. First-round pick Andre Dillard filled in for Peters while he was sidelined.

Cornerback Sidney Jones, who was inactive last week, will suit up against the Patriots after his one-week absence.

Here is the full list of Eagles inactives for Week 11:

- WR Alshon Jeffery (ankle): The veteran wide receiver will miss the Super Bowl LII matchup after failing to practice all week. Jordan Matthews and Nelson Agholor will need to fill the void.

- RB Jordan Howard (shoulder): The running back will be a big loss for the Eagles. He will be supplanted by Sanders, who has been playing well in recent weeks.

- LB Nigel Bradham (ankle): Bradham suffered his ankle injury in Week 6. He will probably be replaced by Nathan Gerry at middle linebacker. Kamu Grugier-Hill and T.J. Edwards are likely to see upticks in playing time as well.

- DE Shareef Miller (healthy scratch): With the trade acquisition of Genard Avery, Miller will be on the bench for a while, or at least until there’s an injury at defensive end.

- C Nate Herbig (healthy scratch): The rookie has been a healthy scratch all season.