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Time for a Cleaning?

Research shows that good oral health may actually prevent certain chronic diseases from occuring. In addition to brushing at least twice a day, visiting a dentist every six months can help to keep your mouth in top shape!

NOVEL OCD TREATMENT STUDY AT COLUMBIA UNIVERSITY MEDICAL CENTER

Does your child have obsessive-compulsive disorder (OCD)? Is he or she
currently taking an antidepressant medication but still experiencing OCD
symptoms?

If so, your child may be eligible to participate in a research study providing a known
antibiotic treatment at no cost. This study aims to determine whether adding an FDAapproved
antibiotic medication called minocycline to antidepressant treatment can help
reduce symptoms of pediatric OCD. This study also aims to learn more about the brains
of children, adolescents and young adults with OCD. All information in this study is kept
completely confidential.

In order to be eligible, participants must be:
- Between the ages of 8 and 20 years.
- Currently taking an antidepressant medication such as Fluoxetine (Prozac),
Fluvoxamine (Luvox), Sertraline (Zoloft), Paroxetine (Paxil), Citalopram (Celexa),
Escitalopram (Lexapro) and Clomipramine (Anafranil) and still experiencing OCD
symptoms.

Study Procedures:

- A screening period of 1-2 visits with a free, thorough psychiatric evaluation
and medical evaluation to determine if your child is eligible.

- For the first 12 weeks:
o Medication treatment with minocycline or placebo (pills with no medication
in them) at no cost. There is a 2 out of 3 chance that your child will receive
minocycline.
o 2 brain scans in a magnetic resonance imaging (MRI) machine before and
after treatment.

- After the first 12 weeks:
o 3 additional months of free treatment with medication and/or Cognitive-
Behavioral Therapy (CBT), including Exposure & Response Prevention
(ERP) Therapy.
o Minocycline offered to those who received placebo in the first 12 weeks.

FOR MORE INFORMATION, PLEASE CONTACT:

Pediatric Anxiety and Mood Research Clinic, Columbia University Medical Center / New
York State Psychiatric Institute
(646) 774-5793