Most skin infections do not result in the death of skin and nearby tissues. Sometimes, however, bacterial infection can cause small blood vessels in the infected area to clot. This clotting causes the tissue fed by these vessels to die from lack of blood. Because the body's immune defenses that travel through the bloodstream (such as white blood cells and antibodies) can no longer reach this area, the infection spreads rapidly and may be difficult to control. Death can occur, even with appropriate treatment.

Some necrotizing skin infections spread deep in the skin along the surface of the connective tissue that covers muscle (fascia) and are termed necrotizing fasciitis. Other necrotizing skin infections spread in the outer layers of skin and are termed necrotizing cellulitis. Several different bacteria, such as Streptococcus and Clostridia, may cause necrotizing skin infections, although in many people the infection is caused by a combination of bacteria. The streptococcal infection in particular has been termed “flesh-eating disease” by the lay press, although it differs little from the others.

Some necrotizing skin infections begin at puncture wounds or lacerations, particularly wounds contaminated with dirt and debris. Other infections begin in surgical incisions or even healthy skin. Sometimes people with diverticulitis, intestinal perforation, or tumors of the intestine develop necrotizing infections of the abdominal wall, genital area, or thighs. These infections occur when certain bacteria escape from the intestine and spread to the skin. The bacteria may initially create an abscess (a pocket of pus) in the abdominal cavity and spread directly outward to the skin, or they may spread through the bloodstream to the skin and other organs. People with diabetes are at particular risk of necrotizing skin infections.

Symptoms and Diagnosis

Symptoms often begin just as for cellulitis (see see Cellulitis). The skin may look pale at first but quickly becomes red or bronze and warm to the touch and sometimes swollen. Later, the skin turns violet, often with the development of large fluid-filled blisters (bullae). The fluid from these blisters is brown, watery, and sometimes foul smelling. Areas of dead skin turn black (gangrene). Some types of infection, including those caused by Clostridia and mixed bacteria, produce gas (see see Gas Gangrene). The gas creates bubbles under the skin and sometimes in the blisters themselves, causing the skin to feel crackly when pressed. Initially the infected area is extremely painful, but as the skin dies, the nerves stop working and the area loses sensation.

The person usually feels very ill and has a high fever, a rapid heart rate, and mental deterioration ranging from confusion to unconsciousness. Blood pressure may fall because of toxins secreted by the bacteria and the body's response to the infection (septic shock—see see Sepsis and Septic Shock). People may develop toxic shock syndrome (see Toxic Shock Syndrome).

A doctor makes a diagnosis of necrotizing skin infection based on its appearance, particularly the presence of gas bubbles under the skin. X-rays may show gas under the skin as well. A blood test usually shows that the number of white blood cells has increased (leukocytosis). The specific bacteria involved are identified by laboratory analysis of blood or tissue samples. However, treatment must begin before a doctor can be certain which bacteria are causing the infection.

Prognosis and Treatment

The overall death rate is about 30%. Older people, those who have other medical disorders, and those in whom the disease has reached an advanced stage have a poorer outcome. A delay in diagnosis and treatment and insufficient surgical removal of dead tissue worsen the prognosis.

The treatment for necrotizing fasciitis is surgical removal of the dead tissue plus antibiotics given by vein (intravenously). Large amounts of skin, tissue, and muscle must often be removed, and in some cases, an affected arm or leg may have to be amputated. People may need large volumes of intravenous fluids before and after surgery. Some doctors recommend treatment in a high-pressure (hyperbaric) oxygen chamber, but it is not clear how much this helps. People who also develop toxic shock syndrome may be given intravenous immune globulinSome Brand NamesGammagard S/D.