Today many patients experience multiple illnesses and can therefore be considered to suffer from comorbidity. The medical and nursing care in hospitals is rarely prepared to meet their needs and is often focused on curing the primary reason of admission. The purpose of this study was therefore to investigate how nurses understand the realization of holistic nursing of patients with comorbidity based on the following questions: What is holistic nursing of patients with comorbidity and how is it carried out? Through interviews on the basis of the phenomenographic approach we have tried to capture nurses understanding of these questions. The result of the study is an outcome space with ten categories of description that describes that nurses understand holistic nursing of patients with comorbidities as a nursing with a comprehensive view which is patient centered. This type of nursing can be achieved if the nurses strive for an individually adapted care and cooperate with others. To make this possible there are several conditions that has to be met.