The 42-year-old talk-show host, chef, author and entrepreneur — who first came to prominence on Bravo’s “The Real Housewives of New York City” and later parlayed her “Real” fame into spin-off shows “Bethenny Getting Married?” and “Bethenny Ever After” — announced yesterday she and husband Jason Hoppy have separated.

“This was an extremely difficult decision that, as a woman and a mother, I have to accept as the best choice for our family,” Frankel said.

“We have love and respect for one another and will continue to amicably co-parent our daughter, who is and will always remain our first priority,” she said. “This is an immensely painful and heartbreaking time for us.”