The Mona Lisa was Earth's most famous painting. It was painted multiple times by Leonardo da Vinci. The Fourth Doctor wrote "THIS IS A FAKE" on the canvasses da Vinci was to paint the extra Mona Lisa's on and instructed da Vinci to just paint over words. He also told da Vinci that everyone loved The Last Supper (TV: City of Death)

The Abomination was the masterpiece of Giuseppe di Cattivo and was stored underneath the International Gallery. It was painted with pigments made from sentient rock that fell to Earth. When a copy of the Mona Lisa, also painted with sentient meteorite was stored in the same Gallery, the paintings awoke, animating other paintings (including The Dark Rider) and putting people into paintings. (TV: Mona Lisa's Revenge)