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Abstract

STUDY THE ALTERATION OF ANTIOXIDANTS AND MALONDIALDEHYDE IN HEMODIALYSIS PATIENTS WITH CHRONIC RENAL FAILURE IN TAIZ, YEMEN

Dr. Salwa AL-Shamiri*

ABSTRACT

Background: Chronic Renal Failure is occur with exhausted oxidative stress, which is a sequel of increasing in the production of reactive oxygen forms accompanied with the impaired antioxidant defense. Objectives: The aim of this study is to detect the alteration in the antioxidants and oxidative stress that influenced by hemodialysis in chronic renal failure patients. Methods: Blood samples were drawn from thirty controls and sixty patients with chronic renal failure at the artificial kidney units of Al-Thawra Teaching Hospital in Taiz, Yemen in the period from September 2014 to January 2015. In this study, catalase, glucose-6-phosphate dehydrogenase activities, endogenous non-enzymatic antioxidants, and malondialdehyde were measured in the plasma of patients before and after dialysis. Results: Plasma level of malondialdehyde was significantly increased in pre and post hemodialysis groups as compared to the control group and it was found to be lower in post hemodialysis group when compared with pre hemodialysis group. The plasma activity of glucose-6-phosphate dehydrogenase was significantly decreased in pre and post hemodialysis groups as compared with control group. The significant decreasing in catalase activity was presented in the post hemodialysis group as compared with the pre hemodialysis group. Conclusions: The significant decreasing in most antioxidative studied with increasing in malondialdehyde level in hemodialysis groups are strongly showed the incidence of oxidative stress and lipid peroxidation that may be accompanied to uremia and the dialysis procedure itself.