Liver X receptors (LXR) are a family of ligand-activated transcription factors originally characterised in studies of lipid metabolic signaling and now realised to be important in conditions as diverse as nervous system development, oncology and thrombosis. As well as regulating cholesterol and fatty acid homeostasis they have other physiological functions including glucose homeostasis, immunological, and neuroprotective[1]. They are the nuclear receptor target of oxysterols, the oxidized forms of cholesterol, and several steroid analogues have been developed as agonists. There are two distinct genes that code for: