The intersection of autism and ADHD

This is a Clinical Investigator Award, providing an opportunity for a medical investigator to develop into an independent researcher. Studies of Attention-Deficit/Hyperactivity Disorder (ADHD) within birth records-based Missouri population samples suggest that a severe combined subtype of ADHD defined by population-based criteria is a distinct form of ADHD. Specifically, this population-defined form of ADHD appears to be a genetically distinct disorder, with a characteristic developmental profile that includes elevated levels of autistic symptoms and motor problems. The current project aims to replicate and expand upon these findings using available datasets plus additional assessments that will aid in characterizing the neurodevelopmental phenotype of children with severe combined type ADHD. This study will attempt to improve diagnostic classification of childhood and adolescent disorders such as ADHD and autism spectrum disorders. Refinement of ADHD phenotypes involving autistic traits and/or motor problems may facilitate future genetic studies, longitudinal outcome studies, and clinical treatment trials.