Pharmacokinetics and Evaluation of the Safety of Cefepime Administered to Rabbits

Resumen

The aim of this study was to determine the kinetic behaviour and the safety of cefepime administered to rabbits. For this, rabbits (n = 29) were used and distributed in Groups 1 (G1), 2 (G2) and
Control (CG). Animals from G1 (n = 21) received a monodose of cefepime intravenously, (20 mg/kg
weight) and, after this, blood samples were collected, controlling the time. Rabbits from Group G2 (n = 4)
received multidoses of cefepime (20 mg/kg weight, intravenously), and blood and urine samples were taken
in order to analyse them. Animals from Groups G2 and CG were controlled electrocardiographically
(ECG) throughout the treatment. Rabbits from Group CG (n = 4) were evaluated and samples were obtained in the same way and within the same time periods as G2. The concentration-time curves of cefepime
were determined using a biological method, and it was analysed through a non-compartmental model. The
pharmacokinetic results (Mean ± S.D.) were: t½ = 1.6 ± 0.4 h; AUC = 212.1 ± 82.1 μg/mL.h; AUMC =
387.4 ± 132.2 μg/mL.h; Vss
= 216.7 ± 63.4 mL/kg; CL = 99.7 ± 19.4 mL/kg y TMR = 2.0 ± 0.4 h. The cefepime administered to rabbits in therapeutic doses did not produce any biochemical, electrocardiographic or renal modification.

Información general

Fecha de publicación:2012

Idioma del documento:Inglés

Revista:Latin American Journal of Pharmacy; vol. 31, no. 02

Institución de origen:Colegio de Farmacéuticos de la Provincia de Buenos Aires