Colorectal cancer kills forty five people in France every day. Epidemiological studies suggest that two cases out of three could be prevented and show that processed meat intake is a consistent risk factor. The aim of this study is to understand how meat promotes cancer, to find protective strategies, and to make compelling dietary recommendations.

Further study details as provided by Institut National de la Recherche Agronomique:

Primary Outcome Measures:

Urinary biomarker (DHN-MA:dihydroxynonene mercapturic acid), will be measured before and after every interventional period [ Time Frame: Twice a week, before and after every 4 days of interventional period ] [ Designated as safety issue: No ]

Secondary Outcome Measures:

Fecal biomarkers [ Time Frame: twice a week, before and after every 4 days of interventional period ] [ Designated as safety issue: No ]

18 healthy volunteers will be randomized and will start the study. The study will last 4 weeks for each subject. The first week will be a week of adaptation (or run-in period) to the diet which they will have to follow for the duration of study. During this period, they will collect 2 samples of stools and urine. Then subjects will alternate 4 days of diet either with ham, or with ham and calcium, or with ham enriched with vitamin E. At least, 3 days will separate every period (wash-out) of nutritional intervention. Urines and stools will be collected last 3 days of every interventional period and also last day of every wash out period.

Eligibility

Ages Eligible for Study:

40 Years to 75 Years

Genders Eligible for Study:

Male

Accepts Healthy Volunteers:

Yes

Criteria

Inclusion Criteria:

Male

Body mass index 20 <= BMI <= 30 kg/m2

Affiliated to French National Health Insurance

Subject giving his written informed consent

Subject considered as normal after clinical examination and medical questionnaire

Exclusion Criteria:

Positive serologies to HIV or HCV, determined on blood samples

Previous medical and/or surgery judged by the investigator as incompatible with this study

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To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below.
For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00994526