The instability of the natural form of the trimer complex in the laboratory has been a major obstacle to the creation of a successful vaccine, as the individual dissociated components, monomeric gp120 and gp41, do not elicit antibodies that neutralize clinical strains of HIV.

When a wild-type-compatible probe is used, the apolipoprotein B-3500 G10699A mutation causes a G-T mismatch in the trimer CGG/GTC, which is more stable than the C-A mismatch in the trimer ACG/TAC caused by the C10698T mutation (10,11).

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