Irene Demova Virus

"Be on the lookout for the Irene Demova virus. It's nasty, highly contagious, and will destroy your computer. To avoid contracting this deadly ailment, DO NOT visit the Irene Demova website."

―From the web

Irene Demova Virus is a computer virus, named after the Serbian porn star Irene Demova, which Chuck describes as a computer killer.The Irene Demova virus is downloaded when someone enters her official website and then it promptly kills the computer that downloaded it.

Within the series Chuck warns the Nerd Herders about the virus saying its a new virus that's going around and demonstrates the effect by downloading the virus into one of the Buy More's Prism Express laptop, which is destroyed. Morgan Grimes manages to fry two computers by going to the Irene Demova website, the first being a display version of a Prism Express laptop and then his own. At the end of the pilot episode, Chuck uses the computer's DOS override to surf the internet and download the virus which, as planned, infects and destroys the computer that controls the bomb, stopping it from going off.

The virus also reappears in the series finale: Chuck vs. the Goodbye. Chuck is trying to disable a bomb set by Nicholas Quinn, meant to kill General Diane Beckman. The bomb is triggered with a Prism Express laptop, which the same model in the first episode. A memory - wiped Sarah then reminds him of the Irene Demova virus, with which Chuck is able to disable the bomb.

The creators of Chuck put out the word pretending that the virus was real and linked to the NBC About Chuck page as the only page with the "cure" for the virus. This worked well as there were many sites created about the virus.