Healthy subjects without thyroid disease, ocular disease and previous surgery in the orbit or eye used in the study.

Graves' Ophthalmopathy - fibrotic phase

Patients that are clinically inactive (CAS equal or lower than 2). This group will be subdivided in the miogenic and lipogenic groups.

Graves' Ophthalmopathy - active phase

Patients that are clinically active, presenting a CAS of 4 or more points, with or without disthyroid optic neuropathy.

Detailed Description:

Prospective study with Grave's patients in active and fibrotic disease, myogenic and lipogenic forms, with muscle restriction and without muscle restriction and with or without optic compressive neuropathy. Blood flow was studied with Color Doppler Imaging (CDI) in the following orbital vessels:

Superior Ophthalmic Vein (main target of the study protocol)

Retinal Central Vein

Retinal Central Artery

Ophthalmic Artery

Eligibility

Ages Eligible for Study:

18 Years to 70 Years

Genders Eligible for Study:

Both

Accepts Healthy Volunteers:

Yes

Sampling Method:

Non-Probability Sample

Study Population

Patients with Grave's disease within the orbital service of HCFMUSP at the Ophthalmology Department

Criteria

Inclusion Criteria:

Clinical diagnosis of Grave's Orbitopathy with well defined disease.

Exclusion Criteria:

Uncertain cases, with an undefined status of Grave's Ophthalmopathy.

Contacts and Locations

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study.
To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below.
For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00697528