[Information provided by:
ClinicalTrials.gov, which provides patients, family members, and members of the public easy and free access to information on clinical studies for a wide range of diseases and conditions.]

- Prior radiation therapy to the brain is allowed with the exception of whole brain irradiation

- Subjects must be neurologically stable for at least 14 days prior to first dose of study drug;

- Male and female subjects who are not surgically sterile or post-menopausal must agree to use reliable methods of birth control for the duration of the study and for 90 days after the last dose of study drug administration; male partners of female subjects should use condoms for the duration of the study, and for 90 days after the last dose of study drug administration

Exclusion Criteria:

- Pregnant or lactating females

- Any evidence of severe or uncontrolled diseases

- Inadequate bone marrow reserve

- Previous whole brain radiotherapy

- Prior RRx-001 therapy

- Insufficient recovery from all side effects of previous anticancer therapies