Pharmacology:
Clomifene inhibits the negative feedback mechanisms of oestrogens
in the hypothalamus and pituitary which stimulates the secretion of
pituitary gonadotrophic hormones resulting in stimulation of
ovulation.
Absorption: Absorbed as citrate in the GI tract (oral).
Metabolism: Hepatic; undergoes enterohepatic recycling.
Excretion: Via the urine and bile; via the faeces (as unchanged
drug and metabolites). 5-7 days (elimination half-life

Indications:
Treatment of anovulatory infertility and that due to polycystic
ovaries.

Dosage & administration:
Oral
Anovulatory infertility
Adult: 50 mg daily for 5 days starting on the 5th day of menstrual
cycle or at any time if there is amenorrhoea. If ovulation does not
occur, a 2nd course of 100 mg for 5 days may be used commencing as
early as 30 days after the previous therapy. Further treatment may
not be recommended if pregnancy has not occurred after a total of 6
treatment cycles.

Pregnancy & Lactation:
Category X: Studies in animals or human beings have demonstrated
foetal abnormalities or there is evidence of foetal risk based on
human experience or both, and the risk of the use of the drug in
pregnant women clearly outweighs any possible benefit. The drug is
contraindicated in women who are or may become pregnant.

Storage:
Store in a well closed container, protected from light.
Store below 25°C.
Do not remove the blister from the carton until required for use.
KEEP OUT OF REACH OF CHILDRENPacking presentations:
(Also can be packed according to customers requirement)
Pack of 10 tablets