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Although he doesn't have that good of a grasp on how potentiating works, I have noticed that it has something to do with the liver and most people that discuss it seem to talk about taking pills, not so much snorting or smoking their opiates.

Does potentiating smoked black tar heroin work with benadryl, or grapefruit juice? or does it only work with opiates taken orally because of how they go through the liver?

If it DOES work with smoked black tar, should SWIM do it the same way that everyone says to do it with pills?
He plans on taking 1 or 2 25mg benadryls about 30 minutes before smoking the heroin. He isn't sure if he's gonna try the grapefruit juice because he read that it only works with opiates taken orally.

potentiation is the act of speeding up the time it takes to achieve a peak concentration of a specific substance (i.e methadone) in the bloodstream, I wouldn't think white grapefruit would potentiate heroin, as it inhibits an enzyme in the liver that metabolizes the drug, therefore increasing the peak concentration and overall half-life of the drug, but does not bring the effects on quicker. With methadone, for example, if taken intravienously with cyclizine is potentiated and is said to be one of the best opiod rushes achieved (similar to the fabled diconal that junkies used to worship back in the 80's!) I think you could mix cyclizine with heroin to achieve something similar, but as I.Vi'ng heroin produces a rush that is 100 times quicker at passing the blood/brain barrier than morphine, there doesn't really seem to be a need for it, as the hit takes all of 5 to 6 seconds to peak anyway, hope this helps