Naloxone

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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#:
318301

CAS#:
465-65-6 (free base)

Description:
Naloxone is a μ-opioid receptor (MOR) inverse agonist. Naloxone has an extremely high affinity for μ-opioid receptors in the central nervous system (CNS). Its rapid blockade of those receptors often produces rapid onset of withdrawal symptoms. Naloxone also has an antagonist action, though with a lower affinity, at κ- (KOR) and δ-opioid receptors (DOR). The mechanism of action is not completely understood, but studies suggest it functions to produce withdrawal symptoms by competing for opiate receptor sites within the CNS (a competitive antagonist, not a direct agonist), thereby preventing the action of both endogenous and xenobiotic opiates on these receptors without directly producing any effects itself. Naloxone was approved for opioid overdose by the Food and Drug Administration in 1971.

Price and Availability

Size

Price

100mg

USD 650

1g

USD 2250

Size

Price

200mg

USD 950

2g

USD 3250

Size

Price

500mg

USD 1450

Naloxone free base, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.

17: Administration of Naloxone in a Home or Community Setting: A Review of the Clinical Effectiveness, Cost-effectiveness, and Guidelines [Internet]. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2014 Jun 20. Available from http://www.ncbi.nlm.nih.gov/books/NBK259232/ PubMed PMID: 25520990.