Interferon Inducible Transmembrane Proteins (IFITMs) can restrict the entry of a wide range of viruses. IFITM3 localizes to endosomes and can potently restrict the replication the influenza A virus (IAV), and several other viruses that also enter host cells through the endocytic pathway. Given...

In response to pathogens, immune cells induce protective effector functions, such as degranulation, phagocytosis and cytokine secretion, which are initiated by stimulatory or inhibitory immunoregulatory receptors expressed on leukocytes. Using a fish immunological model system, the focus of my...