WJPR Citation

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar. Best Paper Award : Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Abstract

DUAL WAVELENGTH SPECTROPHOTOMETRIC METHOD FOR ESTIMATION OF BENIDIPINE HYDROCHLORIDE AND TELMISARTAN IN PHARMACEUTICAL DOSAGE FORM

Khyati Patel*, Darshil Shah and Dr. Dilip Maheshwari

ABSTRACT

The present manuscript describes simple, sensitive, rapid, accurate,
precise and cost effective dual wavelength spectrophotometric method
for the simultaneous determination of Benidipine HCl(BEN) and
Telmisartan(TEL) in combined tablet dosage form. The utility of dual
wavelength data processing program is its ability to calculate unknown
concentration of components of interest in a mixture containing an
interfering component. The principle for dual wavelength method is
―the absorbance difference between two points on the mixture spectra
is directly proportional to the concentration of the component of
interest. The method was based on determination of Benidipine HCl at
the absorbance difference between 228.36nm and 245.39nm and
Telmisartan at the absorbance difference between 280.21 nm and 315.39 nm. The linearity
was obtained in the concentration range of 1-5 μg/ml for Benidipine HCl and 10-50 μg/ml for
Telmisartan. The accuracy and precision of the method was determined and validated
statically. The method showed good reproducibility and recovery with % RSD less than 2.
Method was found to be rapid, specific, precise and accurate, can be successfully applied for
the routine analysis of Benidipine HCl and Telmisartan in bulk, and combined dosage form
without any interference by the excipients. The method was validated according to ICH
guidelines.