Cognitive dysfunctions develop in response to a variety of insults to the CNS including disease or injury and constitute a significant factor with respect to overall function and quality of life. The pathogenesis of cognitive deficits is poorly understood and likely multifaceted. In particular, my lab is focused on elucidating how injury-induced alterations in neurogenesis, innate immune response, oxidative stress, post transcritpition/translational modifications, and chronic neuroinflammation affect various neural processes underlying cognitive function.