The Reeves project is a comedy based on an idea generated by the “Matrix” star. He’ll play an American who becomes a success in London and has to deal with the cultural differences.

They’ve set Michael Kalesniko to script the pic, which they’ll produce with Erwin Stoff at 3 Arts.

The Ford project is a medical drama drawn from “For His Sick Kid,” a Geeta Anand book the studio just acquired, about a man who finances a cure for a rare disease that is killing two of his kids — then has to fight to get them access to the drug. Judith Regan will publish the book.

The producers worked with Ford developing “A Walk Among the Tombstones,” a project from which Ford ultimately walked away. Shamberg said that they’d agreed to try to work together again, and he and Sher approached Ford with “For His Sick Kid,” a tale that originally appeared as an article in the Wall Street Journal.

Shamberg and Sher just closed rights deals for the project and are looking to secure a writer.

Shamberg and Sher formed Double Feature and set it at Universal after ending a 12-year run with Jersey Films partner Danny DeVito that hatched such films as “Pulp Fiction,” “Erin Brockovich,” “Get Shorty” and “Matilda.” The trio share producing credit on the John Hamburg-directed Ben Stiller-Jennifer Aniston starrer “Along Came Polly” and on “Garden State,” directed by Zach Braff and starring Braff and Natalie Portman. Latter film will be the first pic with the Double Feature logo.

With DeVito, Shamberg and Sher also will produce “Be Cool,” the “Get Shorty” follow-up that begins production Feb. 12 with F. Gary Gray directing at MGM.

The duo and DeVito also will share producing duties on “Freedom Writers,” a fact-based film written and to be directed by Richard LaGravanese for Miramax this summer.