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Corn Lab Illuminates 'Black Box' of Post-CRISPR-Cas9 DNA Repair

New Research from the lab of MCB Assistant Adjunct Professor and Scientific Director of the Innovative Genomics Initiative Jacob Corn sheds light on the 'black box' of how cells repair their DNA after the CRISPR-Cas9 enzyme makes its incision, and demonstrates that many of the common assumptions on how this repair occurs are incorrect.

It's currently unknown why some cells repair their DNA efficiently and others do so more infrequently, but Corn and his team have discovered that a little-known DNA pathway called the Fanconi anemia pathway could lead to more successful genome editing therapeutics in the future.