HPA Adapt is a formulation of five powerful, yet non-stimulating adaptogens shown to support a healthy stress response via the hypothalamic-pituitary-adrenal axis, or HPA axis, which is the central part of the stress response system. It involves a complex set of interactions and feedback loops between the hypothalamus, the pituitary, and the adrenal glands.

The HPA axis also plays a role in the regulation of other systems of the body, including the gastrointestinal, neurological, and immune systems. Therefore, supporting optimal HPA axis function is important to maintaining overall health and wellness. Published human and animal research suggests that these ingredients help promote a healthy response to stressors while reducing
stress-related fatigue and mental tension.

These ingredients are:

Ashwagandha root and leaf: is an adaptogenic herb historically used in Ayurveda to enhance well-being, support restful sleep, and reduce occasional anxiety.

A double-blind, placebo-controlled clinical trial
(N =39) evaluated the adaptogenic effects of
ashwagandha. Compared to placebo, the extract
exerted an anti-fatigue effect that increased
mental performance, particularly the ability to
concentrate, and decreased cortisol response to
stress in people with burnout.

Eleuthero root: is an adaptogenic herb that helps
reduce fatigue, supports attention and cognition,and helps the body cope during periods of
stress.

Animal research has shown that
eleuthero supports healthy cortisol production
under stress, though this has not yet been
demonstrated in human clinical trials.

Holy Basil leaf: A member of the mint family, holy basil enhances the body's natural response to physical and emotional stress.

Compounds isolated from the herb's leaves were shown to normalize plasma cortisol levels in an animal model.

Another animal study found that extracts of holy basil
decreased serum concentrations of cortisol.

A clinical trial with 35 subjects demonstrated a
decrease in stress and occasional anxiety after
60 days of supplementation with holy basil.

The participants also showed improved attention and
an increased ability to adapt to change.

Maca root: Preliminary human research suggests that maca may have a positive influence on mood, feelings
of occasional anxiety, and libido.

Although it has not been demonstrated in human clinical
studies, animal research has also documented a
positive effect of maca on cognitive function and
occasional fatigue.

Rhodiola root: Various extracts of Rhodiola have been shown in human clinical studies to reduce fatigue, while
improving mood, attention, and cognitive function, particularly during times of stress.

Further information is available in Dr Priscilla Slagle's medical issue Newsletters

For more guidance on how to use nutritional supplementation, go to Dr Slagle's individual website.
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* These statements have not been evaluated by the U.S.Food & Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease