STRING allows inspection of the interaction evidence for any given network. Choose any of the viewers above (disabled if not applicable in your network).

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:query proteins and first shell of interactors

white nodes:second shell of interactors

Node Content

empty nodes:proteins of unknown 3D structure

filled nodes:some 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

engB

GTPase essential for cell cycle; Necessary for normal cell division and for the maintenance of normal septation (206 aa)

Predicted Functional Partners:

IL2391

YjeB/RRF2 family transcriptional regulator (150 aa)

0.762

der

GTPase EngA; GTPase that plays an essential role in the late steps of ribosome biogenesis (479 aa)

0.729

def

N-formylmethionyl-tRNA deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (174 aa)

0.726

IL0028

Cytochrome c4 (208 aa)

0.715

era

GTPase Era; An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (305 aa)

0.713

lptD

Organic solvent tolerance protein OstA; Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane (757 aa)

0.668

IL0026

Permease (277 aa)

0.660

typA

GTP-binding regulator BipA/TypA (613 aa)

0.620

rsmG

16S rRNA methyltransferase GidB; Specifically methylates the N7 position of guanine in position 527 of 16S rRNA (206 aa)

a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1

node2

node1 accession

node2 accession

node1 annotation

node2 annotation

score

IL0026

IL0028

IL0026

IL0028

Permease

Cytochrome c4

0.441

IL0026

engB

IL0026

IL0027

Permease

GTPase essential for cell cycle; Necessary for normal cell division and for the maintenance of normal septation

0.660

IL0028

IL0026

IL0028

IL0026

Cytochrome c4

Permease

0.441

IL0028

engB

IL0028

IL0027

Cytochrome c4

GTPase essential for cell cycle; Necessary for normal cell division and for the maintenance of normal septation

0.715

IL2391

engB

IL2391

IL0027

YjeB/RRF2 family transcriptional regulator

GTPase essential for cell cycle; Necessary for normal cell division and for the maintenance of normal septation

0.762

def

engB

IL0018

IL0027

N-formylmethionyl-tRNA deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions

GTPase essential for cell cycle; Necessary for normal cell division and for the maintenance of normal septation

0.726

der

engB

IL2030

IL0027

GTPase EngA; GTPase that plays an essential role in the late steps of ribosome biogenesis

GTPase essential for cell cycle; Necessary for normal cell division and for the maintenance of normal septation

0.729

der

era

IL2030

IL0809

GTPase EngA; GTPase that plays an essential role in the late steps of ribosome biogenesis

GTPase Era; An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism

0.644

der

rsmG

IL2030

IL2629

GTPase EngA; GTPase that plays an essential role in the late steps of ribosome biogenesis

16S rRNA methyltransferase GidB; Specifically methylates the N7 position of guanine in position 527 of 16S rRNA

0.730

der

typA

IL2030

IL2438

GTPase EngA; GTPase that plays an essential role in the late steps of ribosome biogenesis

GTP-binding regulator BipA/TypA

0.527

engB

IL0026

IL0027

IL0026

GTPase essential for cell cycle; Necessary for normal cell division and for the maintenance of normal septation

Permease

0.660

engB

IL0028

IL0027

IL0028

GTPase essential for cell cycle; Necessary for normal cell division and for the maintenance of normal septation

Cytochrome c4

0.715

engB

IL2391

IL0027

IL2391

GTPase essential for cell cycle; Necessary for normal cell division and for the maintenance of normal septation

YjeB/RRF2 family transcriptional regulator

0.762

engB

def

IL0027

IL0018

GTPase essential for cell cycle; Necessary for normal cell division and for the maintenance of normal septation

N-formylmethionyl-tRNA deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions

0.726

engB

der

IL0027

IL2030

GTPase essential for cell cycle; Necessary for normal cell division and for the maintenance of normal septation

GTPase EngA; GTPase that plays an essential role in the late steps of ribosome biogenesis

0.729

engB

era

IL0027

IL0809

GTPase essential for cell cycle; Necessary for normal cell division and for the maintenance of normal septation

GTPase Era; An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism

0.713

engB

lptD

IL0027

IL2229

GTPase essential for cell cycle; Necessary for normal cell division and for the maintenance of normal septation

Organic solvent tolerance protein OstA; Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane

0.668

engB

rnr

IL0027

IL1943

GTPase essential for cell cycle; Necessary for normal cell division and for the maintenance of normal septation

Exoribonuclease R; 3’-5’ exoribonuclease that releases 5’-nucleoside monophosphates and is involved in maturation of structured RNAs

0.580

engB

rsmG

IL0027

IL2629

GTPase essential for cell cycle; Necessary for normal cell division and for the maintenance of normal septation

16S rRNA methyltransferase GidB; Specifically methylates the N7 position of guanine in position 527 of 16S rRNA

0.597

engB

typA

IL0027

IL2438

GTPase essential for cell cycle; Necessary for normal cell division and for the maintenance of normal septation

GTP-binding regulator BipA/TypA

0.620

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Network Stats

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Functional enrichments in your networkNote: some enrichments may be expected here (why?)

Enrichment analysis is still ongoing, please wait ...

Statistical background

For the above enrichment analysis, the following statistical background is assumed: