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Friday, October 14, 2016

To most experimental human biologists, among whose company I
include myself, life, in its most basic form, is a series of biological steps,
relentless biological steps but beautifully masterminded by genes, orchestrated
by hormones and managed by enzymes. These biological steps are shaped by our biological
clock, our age, our sex, and by a myriad of inherited factors. They are also
shaped by the food we eat and the drugs we take which together, dominate human
biology experimental studies. From time
to time, we face assertions that biological processes can be mastered by mental
power. We accept that relaxation causes biological effects but do so with the
same thought process that tells us that physical activity causes biological
effects. We even accept that relaxation can be trained to quite high levels
through techniques of, for example yoga or other forms of meditation. The
neurological systems are very complex and thus those not expert in the field of
neurobiology simply accept such findings on trust.

Now data is beginning to emerge that one of the most measured
aspects of life, blood glucose, might be somehow subject to forces other than
food, exercise, drugs, disease and other such tangible matters. We are now
beginning to see mental forces enter this once biological citadel. This summer,
a paper[1],[2]
appeared in the highly rated scientific journal, “The proceedings of the National Academy of Sciences (PNAS)” which
opens up a whole new vista on mind and biology.

Volunteers suffering from type-2 diabetes (the type
associated with obesity as a causative factor) were recruited. All were
receiving dietary management therapy and also they were taking metformin as a
medical treatment to manage their diabetes. Prior to the study, they were asked
to monitor their blood glucose levels before and after every meal and to create
a diary of blood glucose fluctuations. Thus they were trained to fully
understand their own blood glucose measurements. On the morning of the study,
they were asked to arrive having fasted for at least 8 hours. They were asked
to hand in phones, watches and anything else that could be used to monitor time
such as fit-bits, bleepers, computers, etc. They were also asked to hand in all
medication. Now they were ready for the study, which quite frankly was straightforward:
sit, relax and watch videos, changing the video every 15 minutes (the actual
changing of the video was done by the research staff so the volunteers simply
sat and relaxed).

Having taken away all time-related devices, the subjects were
left with just one indicator of time, a wall clock. And herein lies the rub. The
true time spent by each group was 90 minutes. However, two groups were tricked.
For one third of the subjects, the clock was set perfectly accurate and when
the allotted 90 minutes was up, they could see so on the clock. For the other
two groups, the clock was rigged. For half, it ran twice as fast as it should
in reality and for the other, it ran half as slow as reality. Thus one group
spent the true allotted 90 minutes in the test. For another group, the test
lasted just 45 minutes and for the third group, the time taken was 180 minutes.
Blood samples were taken before and after the test and the drop in blood
glucose noted. At the conclusion of the test, the subjects were asked to state
how long the study lasted and they all more or less agreed with the clock, even
though all of them had just spent 90 minutes under the the test conditions.
They did not differ in terms of perceived stress but hunger ratings did differ.
Those with the fast clock showed the highest level of hunger compared to those
rigged to imagine a longer time period. The critically important finding was
that the blood glucose levels were dramatically altered by the covert
manipulation of time.

Group

Perceived time

(Minutes)

Real time

(Minutes)

Blood glucose

Decrease over the study (milligrams
per deciliter)

1

59

90

-10

2

112

90

-15

3

175

90

-24

The authors conclude thus: “Our findings that the mind can actually adjust the body’s glucose
suggests new avenues for treatment and prevention”.The study was well conducted by experts in
psychology from Harvard and Milan. But at the end of the day, experimental
biologists should really not be surprised. We use placebo treatments in our
study and expect always to see some placebo effect albeit very differently fro
the true treatment effect. But it does reinforce the need to have much stronger
links between the biological and behavioural sciences.

Note: Almost 60 years ago, in a review in Science[3],
the effect of tricking people on time as regards appetite were reported by the
great Stanley Schachter at Columbia and these effects are covered in a chapter
in my new book on obesity. The dictum that “an hour in the library saves days
in the lab” still rings true!

My new popular science book on obesity: "Ever seen a fat fox ~ Human obesity explored" is outlined

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"Ever seen a fat fox ~ Human obesity explored"

About Me

I graduated from University College Dublin in 1971 with an Masters in Agricultural Chemistry, took a PhD at Sydney University in 1976 and joined the University of Southampton Medical School as a lecturer in human nutrition in 1977. In 1984 I returned to Ireland to take up a post at the Department of Clinical Medicine Trinity College Dublin and was appointed as professor of human nutrition. In 2006 I left Trinity and moved to University College Dublin as Director of the UCD Institute of Food and Health. I am a former President of the Nutrition Society and I've served on several EU and UN committees on nutrition and Health. I have published over 350+ peer reviewed scientific papers in Public Health Nutrition and Molecular Nutrition and am principal investigator on several national and EU projects (www.ucd.ie/jingo; www.food4me.org). My popular books are "Something to chew on ~ challenging controversies in human nutrition" and "Ever seen a fat fox: human obesity explored"