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Antidepressants and Alcohol Don’t Mix

All antidepressants carry the warning not to mix them with other medication without medical consultation, and, specifically, not to mix antidepressants and alcohol at all. You should not drink alcohol with antidepressants like sertraline (Zoloft) both because alcohol can interact badly with the drug and cause negative side effects, and because alcohol can make depression worse.

Depression and Alcohol

Alcohol is known as a "depressant" drug due to its effect on the body. In addition to reducing inhibitions, increasing talkativeness and slowing reaction times, alcohol can also increase depression symptoms both when drinking and afterwards.

Antidepressants and Alcohol

Alcohol can also reduce the effectiveness of antidepressants, making you feel more depressed and possibly making your depression harder to treat. In addition to directly making you feel more depressed, taking antidepressants and alcohol together can:2

Increase drowsiness, particularly when combined with other medications like sleeping or anti-anxiety drugs