Dosage and
administration : The
recommended daily dose of Sonib is 400 mg (2 x 200 mg tablets) taken twice daily without
food (at least 1 hour before or 2 hours after a meal). Treatment should
continue until the patient is no longer clinically benefiting from therapy or
until unacceptable toxicity occurs. It is recommended that Sorafenib should be
administered without food or with a low or moderate fat meal. If the patient
intends to have a high-fat meal, Sorafenib tablets should be taken at least 1
hour before or 2 hours after the meal. The tablets should be swallowed with a
glass of water. Management of suspected adverse drug reactions may require
temporary interruption and/or dose reduction of Sonib. When dose reduction is
necessary, the Sonib dose may be reduced to 400 mg once daily. If additional
dose reduction is required, Sonib may be reduced to a single 400 mg dose every
other day. Or, as directed by the registered physicians.

Use in pregnancy
and lactation : Pregnancy
Category D. Sorafenib

should not be used during pregnancy.
It is not known whether Sorafenib is excreted in human milk.