RT Journal
A1 GERBER MA
T1 TWice-daily therapy for strep?-reply
JF American Journal of Diseases of Children
JO American Journal of Diseases of Children
YR 1989
FD September 1
VO 143
IS 9
SP 997
OP 997
DO 10.1001/archpedi.1989.02150210013003
UL http://dx.doi.org/10.1001/archpedi.1989.02150210013003
AB In Reply.—In the conclusion of our article,1 we attempted to make a distinction between our recommendations and those of the AHA. As Dr Gill has correctly observed, the AHA does not list twice-daily penicillin therapy as an acceptable regimen for the treatment of streptococcal pharyngitis.2 However, based on our findings3 and those of several other investigators,4-8 we believe that twice-daily penicillin V therapy is an effective regimen. The Committee on Infectious Diseases of the American Academy of Pediatrics also notes that "with good compliance, two doses of oral pencillin totaling 800,000 U (500 mg) daily have been reported to be effective."9