What do the observable signs of clumping of nuclear chromatin, cellular swelling and dilation of the ER, detachment of ribosomes from RER, dissociation of polysomes into monosomes, mitochondrial swelling and (when irreversible) amorphous densities in mitochondrail matrices, massive swelling of mitochondria, nuclear pkynosis, karyolysis, karyorrhexis, lysosoma rupture (occurs later) indicate as a pathogenesis of cellular injury?

ischemic and hypoxic injury

what are the clinicopathological correlates of cell injury?

leakage of cystolic enzymes from cells into blood, which has specific mechanisms that influence timing and has a diagnostic application

what are the mechanisms of irreversible cell injur in ischemic and hypoxic injur?