The use of the four new synthesized polyurethane acrylate binders in the pigment print paste for screen printing cotton and polyester fabrics and pigment fixation through the polymerization process of the binder by using the thermofixation technique as well as the UV curing technique was studied. The effect of changing time and temperature of thermofixation, and the time of UV curing on the color strength, and prints fastness properties were also studied. The results showed that, the newly synthesized polyurethane acrylate binders could be successfully used for pigment fixation on cotton and polyester using the two fixation techniques and in general their prints possessed better color strength values as compared to those obtained upon using the selected commercial binders.