I have personally dealt with humans who have blown half of their skull off with a self inflicted 12 ga, had their crainum split 50/50 with a machete, had an entrance and exit would through the head, chest or abdomen with everything from .22 to .38 to .45 to 30-06, and had their entire body crushed from the chest down in an MVA. I was able to converse with every one of them. In some cases, they were screaming and hurt like hell, other cases they didn't know they'd been hit.

I've also dealt with people who have died from bee strings and knife wounds to the bicep.