Fusion

STRING allows inspection of the interaction evidence for any given network. Choose any of the viewers above (disabled if not applicable in your network).

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:query proteins and first shell of interactors

white nodes:second shell of interactors

Node Content

empty nodes:proteins of unknown 3D structure

filled nodes:some 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

IMP4

Component of the SSU processome, which is required for pre-18S rRNA processing; interacts with Mpp10p; member of a superfamily of proteins that contain a sigma(70)-like motif and associate with RNAs; Required for the early cleavages at sites A0, A1 and A2 during 18S ribosomal pre-RNA processing (290 aa)

Predicted Functional Partners:

IMP3

Component of the SSU processome, which is required for pre-18S rRNA processing, essential protein that interacts with Mpp10p and mediates interactions of Imp4p and Mpp10p with U3 snoRNA; Required for the early cleavages at sites A0, A1 and A2 during 18S ribosomal pre-RNA processing (183 aa)

0.999

MPP10

Component of the SSU processome and 90S preribosome, required for pre-18S rRNA processing, interacts with and controls the stability of Imp3p and Imp4p, essential for viability; similar to human Mpp10p; Involved in nucleolar processing of pre-18S ribosomal RNA. Required for the early cleavages at sites A0, A1 and A2 during 18S ribosomal pre-RNA processing (593 aa)

Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis; localizes to both nucleolus and cytoplasm; Involved in the biogenesis of the 60S ribosomal subunit. Required for pre-rRNA processing and cytokinesis. Associates with the precursors of the 25S and 5.8S rRNAs (220 aa)

Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA; Component of the SSU processome, a pre-ribosomal particle required for the maturation of the 18S rRNA from the 35S pre-rRNA precursor (440 aa)

0.999

UTP13

Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA; Involved in nucleolar processing of pre-18S ribosomal RNA (817 aa)

0.999

NOC4

Nucleolar protein, forms a complex with Nop14p that mediates maturation and nuclear export of 40S ribosomal subunits; Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm. Its subcellular location and association with pre-40S subunit are unaffected by RPS19 disruptions, suggesting it acts before the ribosomal protein (552 aa)

0.999

NOP58

Protein involved in pre-rRNA processing, 18S rRNA synthesis, and snoRNA synthesis; component of the small subunit processome complex, which is required for processing of pre-18S rRNA; Required for pre-18S rRNA processing. May bind microtubules (511 aa)

a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1

node2

node1 accession

node2 accession

node1 annotation

node2 annotation

score

IMP3

IMP4

YHR148W

YNL075W

Component of the SSU processome, which is required for pre-18S rRNA processing, essential protein that interacts with Mpp10p and mediates interactions of Imp4p and Mpp10p with U3 snoRNA; Required for the early cleavages at sites A0, A1 and A2 during 18S ribosomal pre-RNA processing

Component of the SSU processome, which is required for pre-18S rRNA processing; interacts with Mpp10p; member of a superfamily of proteins that contain a sigma(70)-like motif and associate with RNAs; Required for the early cleavages at sites A0, A1 and A2 during 18S ribosomal pre-RNA processing

0.999

IMP3

MPP10

YHR148W

YJR002W

Component of the SSU processome, which is required for pre-18S rRNA processing, essential protein that interacts with Mpp10p and mediates interactions of Imp4p and Mpp10p with U3 snoRNA; Required for the early cleavages at sites A0, A1 and A2 during 18S ribosomal pre-RNA processing

Component of the SSU processome and 90S preribosome, required for pre-18S rRNA processing, interacts with and controls the stability of Imp3p and Imp4p, essential for viability; similar to human Mpp10p; Involved in nucleolar processing of pre-18S ribosomal RNA. Required for the early cleavages at sites A0, A1 and A2 during 18S ribosomal pre-RNA processing

0.999

IMP3

NOC4

YHR148W

YPR144C

Component of the SSU processome, which is required for pre-18S rRNA processing, essential protein that interacts with Mpp10p and mediates interactions of Imp4p and Mpp10p with U3 snoRNA; Required for the early cleavages at sites A0, A1 and A2 during 18S ribosomal pre-RNA processing

Nucleolar protein, forms a complex with Nop14p that mediates maturation and nuclear export of 40S ribosomal subunits; Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm. Its subcellular location and association with pre-40S subunit are unaffected by RPS19 disruptions, suggesting it acts before the ribosomal protein

0.999

IMP3

NOP15

YHR148W

YNL110C

Component of the SSU processome, which is required for pre-18S rRNA processing, essential protein that interacts with Mpp10p and mediates interactions of Imp4p and Mpp10p with U3 snoRNA; Required for the early cleavages at sites A0, A1 and A2 during 18S ribosomal pre-RNA processing

Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis; localizes to both nucleolus and cytoplasm; Involved in the biogenesis of the 60S ribosomal subunit. Required for pre-rRNA processing and cytokinesis. Associates with the precursors of the 25S and 5.8S rRNAs

0.996

IMP3

NOP58

YHR148W

YOR310C

Component of the SSU processome, which is required for pre-18S rRNA processing, essential protein that interacts with Mpp10p and mediates interactions of Imp4p and Mpp10p with U3 snoRNA; Required for the early cleavages at sites A0, A1 and A2 during 18S ribosomal pre-RNA processing

Protein involved in pre-rRNA processing, 18S rRNA synthesis, and snoRNA synthesis; component of the small subunit processome complex, which is required for processing of pre-18S rRNA; Required for pre-18S rRNA processing. May bind microtubules

0.998

IMP3

PWP2

YHR148W

YCR057C

Component of the SSU processome, which is required for pre-18S rRNA processing, essential protein that interacts with Mpp10p and mediates interactions of Imp4p and Mpp10p with U3 snoRNA; Required for the early cleavages at sites A0, A1 and A2 during 18S ribosomal pre-RNA processing

Component of the SSU processome, which is required for pre-18S rRNA processing, essential protein that interacts with Mpp10p and mediates interactions of Imp4p and Mpp10p with U3 snoRNA; Required for the early cleavages at sites A0, A1 and A2 during 18S ribosomal pre-RNA processing

Component of the SSU processome, which is required for pre-18S rRNA processing, essential protein that interacts with Mpp10p and mediates interactions of Imp4p and Mpp10p with U3 snoRNA; Required for the early cleavages at sites A0, A1 and A2 during 18S ribosomal pre-RNA processing

Essential protein required for biogenesis of 40S (small) ribosomal subunit; has similarity to the beta subunit of trimeric G-proteins and the splicing factor Prp4p; Required for ribosomal RNA processing

0.999

IMP3

UTP13

YHR148W

YLR222C

Component of the SSU processome, which is required for pre-18S rRNA processing, essential protein that interacts with Mpp10p and mediates interactions of Imp4p and Mpp10p with U3 snoRNA; Required for the early cleavages at sites A0, A1 and A2 during 18S ribosomal pre-RNA processing

Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA; Involved in nucleolar processing of pre-18S ribosomal RNA

0.999

IMP3

UTP6

YHR148W

YDR449C

Component of the SSU processome, which is required for pre-18S rRNA processing, essential protein that interacts with Mpp10p and mediates interactions of Imp4p and Mpp10p with U3 snoRNA; Required for the early cleavages at sites A0, A1 and A2 during 18S ribosomal pre-RNA processing

Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA; Component of the SSU processome, a pre-ribosomal particle required for the maturation of the 18S rRNA from the 35S pre-rRNA precursor

0.999

IMP4

IMP3

YNL075W

YHR148W

Component of the SSU processome, which is required for pre-18S rRNA processing; interacts with Mpp10p; member of a superfamily of proteins that contain a sigma(70)-like motif and associate with RNAs; Required for the early cleavages at sites A0, A1 and A2 during 18S ribosomal pre-RNA processing

Component of the SSU processome, which is required for pre-18S rRNA processing, essential protein that interacts with Mpp10p and mediates interactions of Imp4p and Mpp10p with U3 snoRNA; Required for the early cleavages at sites A0, A1 and A2 during 18S ribosomal pre-RNA processing

0.999

IMP4

MPP10

YNL075W

YJR002W

Component of the SSU processome, which is required for pre-18S rRNA processing; interacts with Mpp10p; member of a superfamily of proteins that contain a sigma(70)-like motif and associate with RNAs; Required for the early cleavages at sites A0, A1 and A2 during 18S ribosomal pre-RNA processing

Component of the SSU processome and 90S preribosome, required for pre-18S rRNA processing, interacts with and controls the stability of Imp3p and Imp4p, essential for viability; similar to human Mpp10p; Involved in nucleolar processing of pre-18S ribosomal RNA. Required for the early cleavages at sites A0, A1 and A2 during 18S ribosomal pre-RNA processing

0.999

IMP4

NOC4

YNL075W

YPR144C

Component of the SSU processome, which is required for pre-18S rRNA processing; interacts with Mpp10p; member of a superfamily of proteins that contain a sigma(70)-like motif and associate with RNAs; Required for the early cleavages at sites A0, A1 and A2 during 18S ribosomal pre-RNA processing

Nucleolar protein, forms a complex with Nop14p that mediates maturation and nuclear export of 40S ribosomal subunits; Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm. Its subcellular location and association with pre-40S subunit are unaffected by RPS19 disruptions, suggesting it acts before the ribosomal protein

0.999

IMP4

NOP15

YNL075W

YNL110C

Component of the SSU processome, which is required for pre-18S rRNA processing; interacts with Mpp10p; member of a superfamily of proteins that contain a sigma(70)-like motif and associate with RNAs; Required for the early cleavages at sites A0, A1 and A2 during 18S ribosomal pre-RNA processing

Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis; localizes to both nucleolus and cytoplasm; Involved in the biogenesis of the 60S ribosomal subunit. Required for pre-rRNA processing and cytokinesis. Associates with the precursors of the 25S and 5.8S rRNAs

0.999

IMP4

NOP58

YNL075W

YOR310C

Component of the SSU processome, which is required for pre-18S rRNA processing; interacts with Mpp10p; member of a superfamily of proteins that contain a sigma(70)-like motif and associate with RNAs; Required for the early cleavages at sites A0, A1 and A2 during 18S ribosomal pre-RNA processing

Protein involved in pre-rRNA processing, 18S rRNA synthesis, and snoRNA synthesis; component of the small subunit processome complex, which is required for processing of pre-18S rRNA; Required for pre-18S rRNA processing. May bind microtubules

0.999

IMP4

PWP2

YNL075W

YCR057C

Component of the SSU processome, which is required for pre-18S rRNA processing; interacts with Mpp10p; member of a superfamily of proteins that contain a sigma(70)-like motif and associate with RNAs; Required for the early cleavages at sites A0, A1 and A2 during 18S ribosomal pre-RNA processing

Component of the SSU processome, which is required for pre-18S rRNA processing; interacts with Mpp10p; member of a superfamily of proteins that contain a sigma(70)-like motif and associate with RNAs; Required for the early cleavages at sites A0, A1 and A2 during 18S ribosomal pre-RNA processing

Component of the SSU processome, which is required for pre-18S rRNA processing; interacts with Mpp10p; member of a superfamily of proteins that contain a sigma(70)-like motif and associate with RNAs; Required for the early cleavages at sites A0, A1 and A2 during 18S ribosomal pre-RNA processing

Essential protein required for biogenesis of 40S (small) ribosomal subunit; has similarity to the beta subunit of trimeric G-proteins and the splicing factor Prp4p; Required for ribosomal RNA processing

0.999

IMP4

UTP13

YNL075W

YLR222C

Component of the SSU processome, which is required for pre-18S rRNA processing; interacts with Mpp10p; member of a superfamily of proteins that contain a sigma(70)-like motif and associate with RNAs; Required for the early cleavages at sites A0, A1 and A2 during 18S ribosomal pre-RNA processing

Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA; Involved in nucleolar processing of pre-18S ribosomal RNA

0.999

IMP4

UTP6

YNL075W

YDR449C

Component of the SSU processome, which is required for pre-18S rRNA processing; interacts with Mpp10p; member of a superfamily of proteins that contain a sigma(70)-like motif and associate with RNAs; Required for the early cleavages at sites A0, A1 and A2 during 18S ribosomal pre-RNA processing

Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA; Component of the SSU processome, a pre-ribosomal particle required for the maturation of the 18S rRNA from the 35S pre-rRNA precursor

0.999

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Network Stats

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Functional enrichments in your networkNote: some enrichments may be expected here (why?)

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Statistical background

For the above enrichment analysis, the following statistical background is assumed: