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Nigella sativa had been documented to possess many therapeutic
functions in medicine but the least expected is sero-reversion in HIV
infection which is very rare despite extensive therapy with highly
active anti-retroviral therapy (HAART). This case presentation is to
highlight the complete recovery and sero-reversion of adult HIV patient
after treatment with Nigella sativa concoction for the period of six
months. The patient presented to the herbal therapist with history of
chronic fever, diarrhoea, weight loss and multiple papular pruritic
lesions of 3 months duration. Examination revealed moderate weight loss,
and the laboratory tests of ELISA (Genscreen) and western blot (new
blot 1 & 2) confirmed sero-positivity to HIV infection with
pre-treatment viral (HIV-RNA) load and CD4 count of 27,000 copies/ml and
CD4 count of 250 cells/ mm(3) respectively. The patient was commenced
on Nigella sativa concoction 10mls twice daily for 6 months.. He was
contacted daily to monitor side-effects and drug efficacy. Fever,
diarrhoea and multiple pruritic lesions disappeared on 5th, 7th and 20th
day respectively on Nigella sativa therapy. The CD4 count decreased to
160 cells/ mm3 despite significant reduction in viral load (≤1000
copies/ml) on 30th day on N. sativa. Repeated EIA and Western blot tests
on 187th day on Nigella sativa therapy was sero-negative. The post
therapy CD4 count was 650cells/ mm(3) with undetectable viral (HIV-RNA)
load. Several repeats of the HIV tests remained sero-negative, aviraemia
and normal CD4 count since 24 months without herbal therapy. This case
report reflects the fact that there are possible therapeutic agents in
Nigella sativa that may effectively control HIV infection.

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