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Detection of saxitoxin using oligonucleotide as sensing element and organic dye as reporter part

2nd International Conference and Exhibition on Biosensors & Bioelectronics

Abstract

Saxitoxin is a neuron toxin which can block the sodium channel interfering the sodium reflux. It can induce paralysis or even
death. It has bioaccumulation effect and cannot be easily get rid of by simple baking. Therefore, the detection of saxitoxin
is in great need. Through the study of interaction between designed oligonucleotide and saxitoxin in both structural and
thermodynamic ways, we found out that the existence of saxitoxin can effectively interfere the formation of oligonucleotide using
organic dye, the concentration of saxitoxin can be indirectly reflected. This method offers simple preparation and easy operation
and has the potential application in daily life usage.