Previous HGNC Symbols for RAP1GAP Gene

Previous GeneCards Identifiers for RAP1GAP Gene

Summaries for RAP1GAP Gene

Entrez Gene Summary for RAP1GAP Gene

This gene encodes a type of GTPase-activating-protein (GAP) that down-regulates the activity of the ras-related RAP1 protein. RAP1 acts as a molecular switch by cycling between an inactive GDP-bound form and an active GTP-bound form. The product of this gene, RAP1GAP, promotes the hydrolysis of bound GTP and hence returns RAP1 to the inactive state whereas other proteins, guanine nucleotide exchange factors (GEFs), act as RAP1 activators by facilitating the conversion of RAP1 from the GDP- to the GTP-bound form. In general, ras subfamily proteins, such as RAP1, play key roles in receptor-linked signaling pathways that control cell growth and differentiation. RAP1 plays a role in diverse processes such as cell proliferation, adhesion, differentiation, and embryogenesis. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Aug 2011]

GeneCards Summary for RAP1GAP Gene

RAP1GAP (RAP1 GTPase Activating Protein) is a Protein Coding gene.
Among its related pathways are RET signaling and Developmental Biology.
Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and GTPase activator activity.
An important paralog of this gene is RAP1GAP2.

SOURCE GeneReport for Unigene cluster for RAP1GAP Gene:

mRNA Expression by UniProt/SwissProt for RAP1GAP Gene:

Tissue specificity:Significant expression seen in the brain, kidney and pancreas. Abundant in the cerebral cortex and expressed at much lower levels in the spinal cord. Not detected in the lymphoid tissues.