Originally, according to ancient First Century AT studies of human baseline brains, a tiny locus of nerve cells in the temporal lobe of the brain that is highly active curing during religious experiences (as for instance in the seizures of some epileptics) and was thought to be a source of religious belief. Though later studies showed a subtler and more pervasive set of brain activities related to religious experiences and beliefs, the concept remained.

In later usage, a 'god spot' is any somatic, neural, software, wetware, or hardware structure, the stimulation or activation of which is capable of generating numinous experiences. A number of Sophic and Keterist clades have deliberately created quite potent godspot augmentations and mods.