LABORATORY OF RICHARD LEVIS

Department of Molecular Biophysics & Physiology

Richard Levis is interested in ionic channels, voltage gated
ionic channels, signal detection and electrophysiology. He has developed
a number of innovative techniques to investigate the behavior of ion channels.
Recently he has pioneered low noise current recording techniques for patch
clamp. Research in collaboration with J. Tang and R.S. Eisenberg involves
measurements of large conductance channels with significantly improved
time resolution and bandwidth to measure the time required for conformational
changes between open and closed states. In collaboration with K. Lynn and
S. Jovanovic of Brookhaven National Laboratory (Upton, NY) and R.S. Eisenberg,.
Dr. Levis has also been involved in the development of an instrument which
detects and measures single channel currents in real time. Amplitude information,
mean open an closed times, and histograms of open and closed durations
are presented in real time, allowing far more rapid and efficient experimentation.