1. Information on accessing digital images of IHC stains and the
manual requisition form can be accessed through this website:
www.mayomedicallaboratories.com/test-info/ihc/index.html

2. Clients ordering stains using a manual requisition form will
not have access to digital images.

3. Clients wishing to access digital images must place the order
for IHC stains electronically. Information regarding digital
imaging can be accessed through this website:
www.mayomedicallaboratories.com/test-info/ihc/faq.html

Secondary ID

70578

Useful For

Classification of neurodegenerative diseases

Reflex Tests

Test ID

Reporting Name

Available Separately

Always Performed

IHTOA

IHC Additional, Tech Only

No

No

IHTOI

IHC Initial, Tech Only

No

No

Method Name

Immunohistochemistry

Reporting Name

Ubiquitin IHC, Tech Only

Specimen Type

TECHONLY

Specimen Stability Information

Specimen Type

Temperature

Time

TECHONLY

Ambient (preferred)

Refrigerated

Reject Due To

Clinical Information

Ubiquitin is a polypeptide of approximately 8.5 kD found in
filamentous inclusions and cytosome-related organelles in human
idiopathic neurodegenerative diseases, including Alzheimer disease,
Pick disease, Lewy body dementia, and Parkinson disease. Ubiquitin
is also expressed in Rosenthal fibers in astrocytomas. Ubiquitin
protein complexes have also been found in primary lysosome-related
granules in mature neutrophils. Ubiquitin labels the periphery of
senile plaques and of neurofibrillary tangles in Alzheimer disease,
Lewy bodies in Parkinson disease, and Mallory bodies in alcoholic
liver disease.

Interpretation

This test includes only technical performance of the stain (no
pathologist interpretation is performed). Mayo Clinic cannot
provide an interpretation of tech only stains outside the context
of a pathology consultation. If an interpretation is needed, refer
to test code PATHC / Pathology Consultation for a full diagnostic
evaluation or second opinion of the case. All material associated
with the case is required. Additional specific stains may be
requested as part of the pathology consultation, and will be
performed as necessary at the discretion of the Mayo
pathologist.

The positive and negative controls are verified as showing
appropriate immunoreactivity and documentation is retained at Mayo
Clinic Rochester. If a control tissue is not included on the slide,
a scanned image of the relevant quality control tissue is available
upon request. Contact 855-516-8404.

Interpretation of this test should be performed in the context
of the patient's clinical history and other diagnostic tests by a
qualified pathologist.

Day(s) and Time(s) Performed

Monday through Friday

Analytic Time

1 day

Performing Laboratory

Mayo Medical Laboratories in Rochester

Test Classification

This test was developed and its performance characteristics
determined by Mayo Clinic in a manner consistent with CLIA
requirements. This test has not been cleared or approved by the
U.S. Food and Drug Administration.