Italy's high court will once again determine the fate of amanda knox. The american college student who was convicted and acquitted of murdering her roommate. The prosecutors who held her behind bars there for four years are arguing she should be returned to jail. Here's abc's nick schifrin. My family is really the most important thing right now. And I just want to go and be with them. Reporter: Amanda knox waited four years for that homecoming. But tonight, she's anxious that italy's supreme court could put her freedom in jeopardy. The fact that she spent three or four years in an italian prison and this murder charge continues to hang over her head. There is no peace of mind. I couldn't understand why they were so sure I was the one who knew everything. Reporter: In 2007, knox and her italian boyfriend, raffaele sollecite, were convicted of murdering their roommate, meredith kercher. They languished in prison for years. The world watched the dramatic moment they were released. Both defendants have been acquitted. Reporter: But now, prosecutors want to reinstate the murder conviction. Tonight, kercher's family tells the italian media that there's still unanswered questions. We are searching for the truth. But knox's family, who won't be in court tomorrow, hopes this hearing clears her name forever. They call it another example of harassment by the prosecution. If she wins on monday, case closed. It's over. And she can go forward without any further worry. Reporter: But if she loses, knox and sollecito's case goes back to court. And their legal saga goes on. Knox has spent the last year writing her memoir. exclusive interview with diane sawyer next month. Knox says she wants to make writing a career. That could all depend on what the judges in rome decide tomorrow.

This transcript has been automatically generated and may not be 100% accurate.

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