Ch 101.Chemistry Tutorials.3 units (1-0-2):third term.Small group study and discussion on special areas of chemistry, chemical engineering, molecular biology, or biophysics. Instructors drawn from advanced graduate students and postdoctoral staff will lead weekly tutorial sessions and assign short homework assignments, readings, or discussions. Tutorials to be arranged with instructors before registration.Instructors: Gray, Okumura, Stoltz, Tirrell.

Bi/Ch 110.Introduction to Biochemistry.12 units (4-0-8):first term.Lectures and recitation introducing the molecular basis of life processes, with emphasis on the structure and function of proteins. Topics will include the derivation of protein structure from the information inherent in a genome, biological catalysis, the intermediary metabolism that provides energy to an organism, and the use of DNA manipulations, cloning, and expression of proteins in foreign hosts to study protein structure and function.Instructors: Campbell, Parker.

ChE/BE/MedE 112.Design, Invention, and Fundamentals of Microfluidic Systems.9 units (3-0-6):second term.This course combines three parts. First, it will cover fundamental aspects of kinetics, mass-transport, and fluid physics that are relevant to microfluidic systems. Second, it will provide an understanding of how new technologies are invented and reduced to practice. Finally, students in the course will work together to design microfluidic systems that address challenges in Global Health, with an emphasis on students' inventive contributions and creativity. Students will be encouraged and helped, but not required, to develop their inventions further by working with OTT and entrepreneurial resources on campus. Participants in this course benefit from enrollment of students with diverse backgrounds and interests. For chemical engineers, suggested but not required courses are ChE 101 (Chemical Reaction Engineering) and ChE 103abc (Transport Phenomena). Students are encouraged to contact the instructor to discuss enrollment.Instructor: Ismagilov.

Bi/Ch 113.Biochemistry of the Cell.12 units (4-0-8):third term.Lectures and recitation on the biochemistry of basic cellular processes in the cytosol and organelles, with emphasis on membrane and protein trafficking. Specific topics include protein secretion, virus entry, endocytosis, endoplasmic reticulum dynamics, nuclear trafficking, autophagy, apoptosis, and mitochondrial dynamics. The relationship of these processes to human disease will be discussed. Not offered 2017-18.Instructor: Chan.

ChE 114.Solid State NMR Spectroscopy For Materials Chemistry.9 units (3-3-3):second term.Principles and applications of solid state NMR spectroscopy will be addressed with focus on structure and dynamics characterization of organic and inorganic solids. NMR applications in the areas of heterogeneous catalysts, batteries, energy storage materials, etc. will be reviewed. More specific topics include NMR methods in solid state such as magic angle spinning (MAS), cross-polarization (CP), NMR of quadrupole nuclei, multiple pulse and multi-dimensional solid state NMR experiments, dynamics NMR. Hands-on experience will be provided via separate laboratory sessions using solid NMR spectrometers at Caltech Solid State NMR facility.Instructor: Hwang.

ChE 115.Electronic Materials Processing.9 units (3-0-6):third term.Introduction into the gas-phase processing techniques used in the fabrication of electronic materials and devices. Kinetic theory of gases. Surface chemistry and gas-surface interaction dynamics. Film deposition techniques: physical and chemical vapor deposition, atomic layer epitaxy, liquid-phase epitaxy, molecular beam epitaxy. Introduction into plasmas and their role in patterned etching and layer deposition. Charging damage during plasma processing. Determination of key parameters that control the ion energy and flux to the wafer surface. Not offered 2017-18.Instructor: Giapis.

Ch 117.Introduction to Electrochemistry.9 units (3-0-6):second term.Discussion of the structure of electrode-electrolyte interface, the mechanism by which charge is transferred across it, and experimental techniques used to study electrode reactions. Topics change from year to year but usually include diffusion currents, polarography, coulometry, irreversible electrode reactions, the electrical double layer, and kinetics of electrode processes.Instructor: See.

ChE 118.Introduction to the Design of Chemical Systems.9 units (3-0-6):second term.Short-term, open-ended projects that require students to design a chemical process or product. Each team generates and filters ideas, identifies use cases and objectives, evaluates and selects a design strategy, develops a project budget, schedules milestones and tasks, and writes a proposal with supporting documentation. Each project must meet specified requirements for societal impact, budget, duration, person hours, environmental impact, safety, and ethics.Instructor: Vicic.

Ch 120 ab.Nature of the Chemical Bond.Ch 120 a: 9 units (3-0-6), first term:Ch 120 b: (1-1-7), second term.Modern ideas of chemical bonding, with an emphasis on qualitative concepts useful for predictions of structures, energetics, excited states, and properties. Part a: The quantum mechanical basis for understanding bonding, structures, energetics, and properties of materials (polymers, ceramics, metals alloys, semiconductors, and surfaces), including transition metal and organometallic systems with a focus on chemical reactivity. The emphasis is on explaining chemical, mechanical, electrical, and thermal properties of materials in terms of atomistic concepts. Part b: The student does an individual research project using modern quantum chemistry computer programs to calculate wavefunctions, structures, and properties of real molecules.Instructor: Goddard.

ChE 120.Optimal Design of Chemical Systems.9 units (1-6-2):third term.Short-term, open-ended projects that require students to design and build a chemical process or manufacture a chemical product. Each team selects a project after reviewing a collection of proposals. Students use chemical engineering principles to design, build, test, and optimize a system, component, or product that fulfills specified performance requirements, subject to constraints imposed by budget, schedule, logistics, environmental impact, safety, and ethics.Instructor: Vicic.

Ch 121 ab.Atomic-Level Simulations of Materials and Molecules.Ch 121 a: 9 units (3-0-6) second term:Ch 121 b (1-1-7) third term.Atomistic-based methods for predicting the structures and properties of molecules and solids and simulating the dynamical properties. The course will highlight theoretical foundations and applications of atomistic simulations to current problems in such areas as biological systems (proteins, DNA, carbohydrates, lipids); polymers (crystals, amorphous systems, copolymers); semiconductors (group IV, III-V, surfaces, defects); inorganic systems (ceramics, zeolites, superconductors, and metals); organometallics, and catalysis (heterogeneous and homogeneous). Part a covers the basic methods with hands-on applications to systems of interest using modern software. The homework for the 1st 5 weeks emphasizes computer-based solutions. For the exams and 2nd 5 weeks of the homework each student selects a short research project and uses atomistic simulations to solve it. For part b each student selects a more extensive research project and uses atomistic simulations to solve it.Instructor: Goddard.

Ch 122.Structure Determination by X-ray Crystallography.9 units (3-0-6):first term.This course provides an introduction to small molecule X-ray crystallography. Topics include symmetry, space groups, diffraction by crystals, the direct and reciprocal lattice, Patterson and direct methods for phase determination, and structure refinement. It will cover both theoretical and applied concepts and include hands-on experience in data collection, structure solution and structure refinement.Instructor: Takase.

Ch 125 abc.The Elements of Quantum Chemistry.9 units (3-0-6):first, second, third terms.A first course in molecular quantum mechanics consisting of a quantitative treatment of quantum mechanics with applications to systems of interest to chemists. The basic elements of quantum mechanics, the electronic structure of atoms and molecules, the interactions of radiation fields and matter, scattering theory, and reaction rate theory. Part c not offered 2017-18.Instructors: Okumura (a), Miller/Chan (b).

ChE 126.Chemical Engineering Laboratory.9 units (1-6-2):first term.Short-term projects that require students to work in teams to design systems or system components. Projects typically include unit operations and instruments for chemical detection. Each team must identify specific project requirements, including performance specifications, costs, and failure modes. Students use chemical engineering principles to design, implement, and optimize a system (or component) that fulfills these requirements, while addressing issues and constraints related to environmental impact, safety, and ethics. Students also learn professional ethics through the analysis of case studies.Instructor: Vicic.

Ge/Ch 127.Nuclear Chemistry.9 units (3-0-6):first term.A survey course in the properties of nuclei, and in atomic phenomena associated with nuclear-particle detection. Topics include rates of production and decay of radioactive nuclei; interaction of radiation with matter; nuclear masses, shapes, spins, and moments; modes of radioactive decay; nuclear fission and energy generation. Given in alternate years; offered 2017-18.Instructor: Burnett.

ChE 128.Chemical Engineering Design Laboratory.9 units (1-6-2):second term.Short-term, open-ended research projects targeting chemical processes in microreactors. Projects include synthesis of chemical products or nanomaterials, detection and destruction of environmental pollutants, and other gas phase conversions. Each student is required to construct and troubleshoot his/her own microreactor, then experimentally evaluate and optimize independently the research project using chemical engineering principles. Where possible, cost analysis of the optimized process is performed.Instructors: Giapis, Vicic.

Ge/Ch 128.Cosmochemistry.9 units (3-0-6):first term.Examination of the chemistry of the interstellar medium, of protostellar nebulae, and of primitive solar-system objects with a view toward establishing the relationship of the chemical evolution of atoms in the interstellar radiation field to complex molecules and aggregates in the early solar system that may contribute to habitability. Emphasis will be placed on identifying the physical conditions in various objects, timescales for physical and chemical change, chemical processes leading to change, observational constraints, and various models that attempt to describe the chemical state and history of cosmological objects in general and the early solar system in particular. Given in alternate years; offered 2017-18.Instructor: Blake.

ChE 130.Biomolecular Engineering Laboratory.9 units (1-5-3):third term.Design, construction, and characterization of engineered biological systems. Students will propose and execute research projects in biomolecular engineering and synthetic biology. Emphasis will be on projects that apply rational or library-based design strategies to the control of system behavior.Instructor: Vicic.

Ch/ChE 140 ab.Principles and Applications of Semiconductor Photoelectrochemistry.9 units (3-0-6):second, third terms.The properties and photoelectrochemistry of semiconductors and semiconductor/liquid junction solar cells will be discussed. Topics include optical and electronic properties of semiconductors; electronic properties of semiconductor junctions with metals, liquids, and other semiconductors, in the dark and under illumination, with emphasis on semiconductor/liquid junctions in aqueous and nonaqueous media. Problems currently facing semiconductor/liquid junctions and practical applications of these systems will be highlighted. Part b not offered 2017-18.Instructor: Lewerenz (a).

Ch 143.NMR Spectroscopy for Structural Identification.9 units (3-0-6):third term.This course will address both one-dimensional and two-dimensional techniques in NMR spectroscopy which are essential to elucidating structures of organic and organometallic samples. Dynamic NMR phenomena, multinuclear, paramagnetic and NOE effects will also be covered. An extensive survey of multipulse NMR methods will also contribute to a clear understanding of two-dimensional experiments. (Examples for Varian NMR instrumentation will be included.) Not offered 2017-18.

Ch 145.Bioorganic Chemistry of Proteins.9 units (3-0-6):first term.An advanced survey of current and classic topics in bioorganic chemistry/chemical biology. The content will vary from year to year and may include the structure, function, and synthesis of peptides and proteins; enzyme catalysis and inhibition; cellular metabolism; chemical genetics; genomics and proteomics; posttranslational modifications; chemical tools to study cellular dynamics; and enzyme evolution.Instructor: Ondrus.

ChE/Ch 148.Polymer Physics.9 units (3-0-6):third term.An introduction to the physics that govern polymer structure and dynamics in liquid and solid states, and to the physical basis of characterization methods used in polymer science. The course emphasizes the scaling aspects of the various physical properties. Topics include conformation of a single polymer chain under different solvent conditions; dilute and semi-dilute solutions; thermodynamics of polymer blends and block copolymers; rubber elasticity; polymer gels; linear viscoelasticity of polymer solutions and melts; glass transition and crystallization. Not offered 2017-18.Instructor: Wang.

Ch 149.Tutorial in Organic Chemistry.6 units (2-0-4):first term.Discussion of key principles in organic chemistry, with an emphasis on reaction mechanisms and problem-solving. This course is intended primarily for first-year graduate students with a strong foundation in organic chemistry. Meets during the first three weeks of the term. Graded pass/fail.Instructors: Fu, Stoltz.

ChE 151 ab.Physical and Chemical Rate Processes.12 units (3-0-9):second, third terms.The foundations of heat, mass, and momentum transfer for single and multiphase fluids will be developed. Governing differential equations; laminar flow of incompressible fluids at low and high Reynolds numbers; forced and free convective heat and mass transfer, diffusion, and dispersion. Emphasis will be placed on physical understanding, scaling, and formulation and solution of boundary-value problems. Applied mathematical techniques will be developed and used throughout the course.Instructor: Brady.

Ch 153 ab.Advanced Inorganic Chemistry.9 units (3-0-6):second, third terms.Ch 153 a: Topics in modern inorganic chemistry. Electronic structure, spectroscopy, and photochemistry with emphasis on examples from the modern research literature. Ch 153 b: Applications of physical methods toward the characterization of inorganic and bioinorganic species. A range of spectroscopic approaches will be covered. Part b Not offered 2017-18.Instructors: Gray, Winkler (a).

Ch 154 ab.Organometallic Chemistry.9 units (3-0-6):second, third terms.A general discussion of the reaction mechanisms and the synthetic and catalytic uses of transition metal organometallic compounds. Second term: a survey of the elementary reactions and methods for investigating reaction mechanisms. Third term: contemporary topics in inorganic and organometallic synthesis, structure and bonding, and applications in catalysis. Part b not offered 2017-18.Instructor: Peters (a).

ChE/Ch 155.Chemistry of Catalysis.9 units (3-0-6):third term.Discussion of homogeneous and heterogeneous catalytic reactions, with emphasis on the relationships between the two areas and their role in energy problems. Topics include catalysis by metals, metal oxides, zeolites, and soluble metal complexes; utilization of hydrocarbon resources; and catalytic applications in alternative energy approaches. Not offered 2017-18.

BMB/Bi/Ch 170.Biochemistry and Biophysics of Macromolecules and Molecular Assemblies.9 units (3-0-6):first term.Detailed analysis of the structures of the four classes of biological molecules and the forces that shape them. Introduction to molecular biological and visualization techniques.Instructor: Clemons.

ESE/Ge/Ch 172.Atmospheric Chemistry II.3 units (3-0-0):first term.A lecture and discussion course about active research in atmospheric chemistry. Potential topics include halogen chemistry of the stratosphere and troposphere; aerosol formation in remote environments; coupling of dynamics and photochemistry; development and use of modern remote-sensing and in situ instrumentation. Graded pass/fail. Not offered 2017-18.

ESE/Ch 176.Physical Organic Chemistry of Natural Waters.9 units (3-0-6):third term.This course will cover selected aspects of the chemistry of natural and engineered aquatic systems. Lectures cover basic principles of physical-organic and physical-inorganic chemistry relevant to the aquatic environment under realistic conditions. Specific topics that are covered include the principles of equilibrium chemistry in natural water, acid-base chemistry of inorganic and organic acids including aquated carbon dioxide, metal-ligand chemistry, ligand substitution kinetics, kinetics and mechanisms of organic and inorganic redox reactions, photochemical transformations of chemical compounds, biochemical transformations of chemical compounds in water and sediments, heterogeneous surface reactions and catalysis. Thermodynamic, transport, kinetics and reaction mechanisms are emphasized. The primary emphasis during the spring term course will be on the organic chemistry of natural waters emphasizing the fate and behavior of organic compounds and persistent organic pollutants in the global environment.Instructor: Hoffmann.

ChE/BE/MedE 188.Molecular Imaging.9 units (3-0-6):second term.This course will cover the basic principles of biological and medical imaging technologies including magnetic resonance, ultrasound, nuclear imaging, fluorescence, bioluminescence and photoacoustics, and the design of chemical and biological probes to obtain molecular information about living systems using these modalities. Topics will include nuclear spin behavior, sound wave propagation, radioactive decay, photon absorption and scattering, spatial encoding, image reconstruction, statistical analysis, and molecular contrast mechanisms. The design of molecular imaging agents for biomarker detection, cell tracking, and dynamic imaging of cellular signals will be analyzed in terms of detection limits, kinetics, and biological effects. Participants in the course will develop proposals for new molecular imaging agents for applications such as functional brain imaging, cancer diagnosis, and cell therapy. Not offered 2017-18.Instructor: Shapiro.

ChE 190.Special Problems in Chemical Engineering.Up to 9 units by arrangement:any term.Special courses of readings or laboratory instruction. The student should consult a member of the faculty and prepare a definite program of reading, computation, theory and/or experiment. The student must submit a summary of progress at midterm and, at the end of the quarter, a final assignment designed in consultation with the instructor. This course may be credited only once. Grading: either grades or pass/fail, as arranged with the instructor.Instructor: Staff.

BMB/Ch 202 abc.Biochemistry Seminar Course.1 unit:first, second, third terms.A course that includes a seminar on selected topics from outside faculty on recent advances in biochemistry. Students will participate in the seminar along with a formal discussion section with visiting faculty. Students will meet with the Biochemistry seminar speaker in the discussion section for an hour, and then attend the Biochemistry seminar at 4 p.m. BMB Seminars take place 1-2 times per month (usually on Thursdays).

Ch 213 abc.Advanced Ligand Field Theory.12 units (1-0-11):first, second, third terms.A tutorial course of problem solving in the more advanced aspects of ligand field theory. Recommended only for students interested in detailed theoretical work in the inorganic field.Instructor: Gray.

Ch 227 ab.Advanced Topics in Chemical Physics.9 units (3-0-6):third term.The goal of this course is to utilize approaches derived from the chemico-physical to understand what are often considered complex biological problems. The course is a literature driven course with a strong emphasis on student participation. Not offered 2017-18.

Ch 228.Dynamics and Complexity in Physical and Life Sciences.9 units (3-0-6):third term.This course is concerned with the structure-dynamics-function of complex systems, from materials to chemical and biological functions. We will address principles of elementary dynamics as they relate to the nature of the structures involved. An overview of modern techniques, such as those involving lasers, NMR, diffraction and imaging will be overviewed. Applications include areas in physics, chemistry and biology, covering phenomena of interest, from coherence and chaos to molecular recognition and self-assembly. Course requirement, which includes writing a "science paper" and presentation, will be outlined in the first meeting. Not offered 2017-18.

Ch/Bi 231.Advanced Topics in Biochemistry.6 units (2-0-4):third term.Transcriptional regulation in eukaryotes. Topics: the subunit structure of eukaryotic RNA polymerases and their role in transcriptional reactions; the composition of eukaryotic promoters, including regulatory units; general and specific transcription factors; developmental regulatory circuits and factors; structural motifs involved in DNA binding and transcriptional initiation and control. Not offered 2017-18.

Ch 242 ab.Chemical Synthesis.9 units (3-0-6):first, second terms.An integrated approach to synthetic problem solving featuring an extensive review of modern synthetic reactions with concurrent development of strategies for synthesis design. Part a will focus on the application of modern methods of stereocontrol in the construction of stereochemically complex acyclic systems. Part b will focus on strategies and reactions for the synthesis of cyclic systems.Instructors: Stoltz (a), Virgil (b).

Ch 250.Advanced Topics in Chemistry.3 units:third term.Content will vary from year to year; topics are chosen according to the interests of students and staff. Visiting faculty may present portions of this course. In Spring 2016 the class will be a seminar course in pharmaceutical chemistry with lectures by industrial researchers from both discovery (medicinal chemistry) and development (process chemistry) departments. Not offered 2017-18.

Ch 251.Advanced Topics in Chemical Biology.9 units (3-0-6):second term.Content will vary from year to year; advanced topics in chemical biology are chosen according to the interests of students and staff. Visiting faculty may lead portions of this course. In Winter 2018, the seminar course will be interactive classroom learning covering both fundamental discoveries and applied technologies in nucleic acids and genome sciences.Instructors: Dervan, Ondrus.

Ch 280.Chemical Research.Hours and units by arrangement:.By arrangement with members of the faculty, properly qualified graduate students are directed in research in chemistry.

ChE 280.Chemical Engineering Research.:.Offered to Ph.D. candidates in chemical engineering. Main lines of research now in progress are covered in detail in section two.