Destroys an enzyme which inhibits fragmentation of DNA
Destroys nuclear lamins leading to fragmentation of the nucleus
Destroys cytoskeletal proteins leading to membrane blebbing and cell fragmentation

Membrane receptors bind TNF or FasL and send a message to cytoplasm to activate Caspase-8 which cleaves and activates Bid(pro-apoptotic). Caspase-8 moves to mitochondria where it dimerizes and inhibits Bcl-2. Cytochrome C then escapes mitochondria and initiates apoptotic pathway in cell.