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Health Notes

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For an herb, supported by traditional use but minimal or no scientific evidence. For a supplement, little scientific support.

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This supplement has been used in connection with the following health conditions:

Dose: 600 to 1,200 mg a dayAlpha lipoic acid is a powerful natural antioxidant. Preliminary and double-blind trials have found that supplementing 600 to 1,200 mg of lipoic acid per day improves insulin sensitivity and the symptoms of diabetic neuropathy.1, 2, 3, 4, 5, 6, 7, 8 In a preliminary study, supplementing with 600 mg of alpha lipoic acid per day for 18 months slowed the progression of kidney damage in patients with type 2 diabetes.9

Dose: 600 to 1,200 mg a dayAlpha lipoic acid is a powerful natural antioxidant. Preliminary and double-blind trials have found that supplementing with 600 to 1,200 mg of lipoic acid per day improves the symptoms of diabetic nerve damage (neuropathy).1, 2, 3, 4 In a preliminary study, supplementing with 600 mg of alpha-lipoic acid per day for 18 months slowed the progression of kidney damage in people with type 1 diabetes.5

Dose: Refer to label instructionsIn a double-blind trial, obese people who supplemented with alpha-lipoic acid (1,200 or 1,800 mg per day for 20 weeks) resulted in a statistically significant weight loss, compared with a placebo. The amount of weight lost was 6.1 pounds with 1,800 mg per day of alpha-lipoic acid, 3.3 pounds with 1,200 mg per day, and 2.1 pounds with placebo.1 The weight loss was due primarily to a loss of fat mass, as opposed to muscle mass. It is not clear how alpha-lipoic acid works, but it may work by increasing the conversion of fuel to energy in the body. In another double-blind trial, supplementation with alpha-lipoic acid (300 mg per day for 10 weeks) enhanced weight loss in overweight and obese women who were consuming a low-calorie diet. Women who received alpha-lipoic acid lost an average of 3.3 pounds more than women who received a placebo.2

In a small double-blind trial, supplementation with 600 mg of alpha-lipoic acid once a day for three months significantly reduced the frequency of migraine attacks. However, this improvement was not statistically significant when compared with the change in the placebo group.1 Additional research is needed to determine whether alpha-lipoic acid is effective for preventing migraines.

Dose: Refer to label instructionsIn a double-blind trial, supplementation with antioxidants for two months before and for six months during treatment with narrowband ultraviolet B light increased the effectiveness of the ultraviolet light therapy. The antioxidant supplement contained daily 100 mg of alpha-lipoic acid, 100 mg of vitamin C, 40 IU of vitamin E, and 100 mg of cysteine.1

Alpha lipoic acid (ALA) is a vitamin-like antioxidant, sometimes referred to
as the "universal antioxidant" because it is soluble in both fat and
water.1 ALA is manufactured in the body and is found in some foods, particularly liver and yeast.

The information presented in Aisle7 is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires June 2016.

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