Walkthrough

You play as Dante through 20 missions of DmC. There is an overall story throughout those missions, but there's also a lot of flexibility throughout the game. You can go back to any previous mission they have cleared at any time and switch Difficulty Levels at will.

It's best to go through most of the game before trying to get all Collectibles. It's true the Collectibles will increase your Style Rank, but many Collectibles will be completely inaccessible until new Weapons or Abilities are obtained. Once a collectible is found, it will be collected forever on all difficulties.

Replaying missions will allow you to build up and unlock Dante's various Core Abilities and Weapon Abilities. Once those are unlocked, they will stay unlocked throughout all difficulties.