GAS5 exons do not encode a polypeptide product (small nucleolar RNA (snoRNA) sequence) of the 5'TOP gene family; role in the regulation of cell growth; provokes growth arrest; overexpression of GAS5 transcripts is reported to induce apoptosis.

Result of the chromosomal anomaly

Hybrid gene

Description

The 5'-terminal oligopyrimidine sequence of GAS5 was fused to the whole coding sequence of BCL6: GAS5 exon 3 was fused to BCL6 exon 2 (BCL6 exon 1 is noncoding).

To be noted

Additional cases are needed to delineate the epidemiology of this rare entity: you are welcome to submit a paper to our new Case Report section.