Interactive Mobile Learning System can be designed as a tool for implementing the Heutagogy. This approach is considered as a chain of Andragogy, and it has a process. Considering the importance of improving safety in the operation of Railway, there are many facilities in the areas of infrastructure, fleet and operation of this task. The problem that Railway has been faced, is the weakness in the safe operation of these equipment and the maintenance caused by the lack of effective training that can be identified as one of the major contributing factors to the disaster. In this research, size of a population is 3000 drivers of Iran Railways and 340 were selected as sample size. In addition to by studying models and learning approaches through the use of statistical tools, an intelligent model for moving from Training to learning, participatory, ubiquitous and informed, appropriate to the Railway and existing infrastructure by SmartPLS software, validation and implemented. The impact of this system on Safety and the reduction of the actual workplace environmental hazards has been studied. The results of this study indicated that the establishment of interactive mobile learning system effects on safety by influencing Reliability, Accessibility and performance of drivers.