TIGERS BE STILL Becca A. Lewis (here with Zach Winston) is the lovably eccentric art therapist at the heart of this tale straddling the borders of sitcom and surrealism.

Forget the elephant in the room. Depression is a big cat in Tigers Be Still, a relentlessly quirky yet endearing screwball tragicomedy by Kim Rosenstock that debuted at New York's Roundabout Underground in 2010 and is getting a sweet Boston premiere by Zeitgeist Stage Company (at the BCA Black Box through May 5). Now a writer for the Fox sitcom New Girl, Rosenstock the dramatist bears deep imprints of her Yale mentor, Pulitzer-winning queen of quirk Paula Vogel, as well as of fellow Vogel protégé Adam Bock, whose Swimming in the Shallows counts among its characters a shark. But Bock's insouciant predator cruises an aquarium tank; Rosenstock's tiger has escaped from a zoo. And though the beast has been on the loose for a while, it seems the least of the play's small, wounded community's problems.

Director David J. Miller chose Tigers knowing he had in actor Becca A. Lewis a perfect Sherry Wickman, the lovably eccentric art therapist at the heart of the tale — which she narrates. Appearing in the cluttered living room of her childhood home a bright vision in fuchsia, turquoise, and nerdy glasses, she announces that "this is the story of how I stopped being a total disaster and got my life on track, and did not let overwhelming feelings of anxiousness and loneliness and uselessness just, like, totally eat my brain."

Trouble is, Sherry is surrounded by total disasters including a mother so depressed by steroid-induced weight gain that she won't leave her room and a sister who has careered from a broken engagement into a haze of Jack Daniels, Bette Midler, and Top Gun. She's out of her room but won't leave the couch – which is inconvenient because, as an adjunct to her new job as an art teacher, Sherry needs the parlor to perform art therapy on her principal's pent-up son, whose mother died in a car accident. And the principal, fat mom's onetime love, is also toting a fat load of grief — and a gun.

Rosenstock deftly handles this dust-up at the border of sitcom and surrealism, and so does director Miller, orchestrating a performance that's more deeply felt than clownish, with Kelley Estes embracing embarrassment as the soused sister, Zach Winston a hulking mix of deadpan and pain as the teen, and Peter Brown a pillar of stoic absurdity as the principal. The tiger does not appear, but neither, however it lurks, does cliché.

CIRCULAR REASONING

What ate Henry Molaison's brain — or at least the part of it where memory is served — was surgery. In 1953, at the age of 27, the amiable subject of Yesterday Happened: Remembering H.M. (in its world premiere by Catalyst Collaborative@MIT and Underground Railway Theater at Central Square Theater through May 13), underwent an experimental operation aimed at putting an end to his epileptic seizures. But to neuroscientists' surprise, the removal of the guy's hippocampus also removed his ability to form memories. He spent the next 55 years being studied by the white coats as he woke to every moment new.

Dramatic Rep digs deep for catharsis Today is a good day for twenty-something Sherry (Casey Turner): She's out of bed, over her depression, and starting her first-ever job as an elementary art teacher and art therapist.

Company One owns The Brother/Sister Plays Symbolism blows over swampland in The Brother/Sister Plays , a hypnotic trilogy making its area debut courtesy of Company One (at the BCA Plaza through December 3).

ARTSEMERSON'S METAMORPHOSIS | February 28, 2013 Gisli Örn Garðarsson’s Gregor Samsa is the best-looking bug you will ever see — more likely to give you goosebumps than make your skin crawl.

CLEARING THE AIR WITH STRONG LUNGS AT NEW REP | February 27, 2013 Lungs may not take your breath away, but it's an intelligent juggernaut of a comedy about sex, trust, and just how many people ought to be allowed to blow carbon into Earth's moribund atmosphere.