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The San Francisco 49ers return home for "Thursday Night Football" to face their second-straight division opponent, the Los Angeles Rams. Both the 49ers and Rams are coming off of narrow defeats in Week 2.San Francisco is looking for their first win of the season on Thursday.Here's a quick breakdown of the 49ers Week 3 matchup.The 49ers lead the all-time series against the Rams, 68-64-3.San Francisco swept the season series in 2016 against the Rams.

San Francisco has won each of the past three contests against the Rams.The San Francisco 49ers might be coming off a tough 12-3 loss to the Seattle Seahawks in Week 2, but head coach Kyle Shanahan’s squad won’t have too much time to think about it this week.

San Francisco hosts the Los Angeles Rams on Thursday Night Football in Week 3 at Levi’s Stadium. The visiting Rams are 1-1 coming off a 27-20 home loss against the Washington Redskins.L.A. has shown notable signs of improvement from last year, and it’s unlikely head coach Sean McVay’s squad will deal with the same problems that plagued the team during the Jeff Fisher years previously.

This week’s game marks the second time the 49ers and Rams will face each other on "Thursday Night Football". The 49ers beat the Rams, 30-24, on Dec. 2, 1982.Meanwhile, Shanahan has his own issues to deal with, including an offense that has yet to find any sort of continuity over two games.This won’t get any easier against a Rams defense that has allowed just 306 passing yards this season — third best in the NFL so far.Still, there are some intriguing matchups to watch here and some 49ers players easily capable of taking control of the game. And in this slideshow, we’ll focus on the three San Francisco players fans will want to watch during this prime-time matchup.Starting off with one of the Niners’ stars from Week 2, defensive tackle DeForest Buckner.