inhibits NPNT expression through the NFKB signaling pathway and down-regulation of NPNT influences the inhibition of osteoblast differentiation by TNF

importance of TNF in the pathogenesis of systemic lupus erythematosus

potential role of accrued changes in DNA methylation in the development of age-related inflammatory diseases, such as rheumatoid arthritis and polymyalgia rheumatica, in which TNF is a pivotal mediator

displays pathogenic activities in many autoimmune disorders

CELLULAR PROCESS

cell life, proliferation/growth

cell life, cell death/apoptosis

PHYSIOLOGICAL PROCESS

inflammation

PATHWAY

metabolism

signaling

hot responses against pathogens, NF-kappa B signaling pathway

a component

INTERACTION

DNA

RNA

small molecule

protein

OCT1 and NFKB

binding to LITAF

TNF, IL6, and leptin, which have been implicated in insulin sensitivity regulation, regulate the expression of STEAP4

intreracting with UBD (plays an important role in mediating the function of TNF during tumorigenesis by inducing cell cycle deregulation and chromosomal instability, and by inhibiting apoptosis

RHBDF2, a proteolytically inactive member of the rhomboid family, is required for TNF release

correlation between ADM and TNF that could hypothesise the existence of a complex interaction between ADM and this inflammatory cytokine

up-regulates endometrial epithelial cell migration and MFGE8 production, which are critical steps required for the endometrial changes during menstrual cycle as well as during embryonic attachment and invasion