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Observations placeholder

Scotch thistle root and cancer

Identifier

Type of Spiritual Experience

Background

A description of the experience

Bioactivity-guided isolation of antiproliferative compounds from the roots of Onopordum acanthium.

Csupor-Löffler B, Zupkó I, Molnár J, Forgo P, Hohmann J.

Onopordum acanthium has been considered in traditional medicine to be effective against different cancers.

The chloroform extracts of the root, which displayed antiproliferative effect against human tumor cell lines, was subjected to bioactivity-guided multistep chromatographic separation.

This experiment resulted in the isolation of the sesquiterpene lactones

4beta,14-dihydro-3-dehydrozaluzanin C (1),

zaluzanin C (2) and

4beta,15,11beta,13-tetrahydrozaluzanin C (3),

the neolignan nitidanin-diisovalerianate (4), besides

13-oxo-9Z,11 E-octadecadienoic acid (5),

24-methylenecholesterol (6),

alpha-linolenic acid,

linoleic acid,

stigmasterol and

beta-sitosterol.

The structures of the isolated compounds were established through analytical data (NMR, MS), and by comparison of these with those reported in the literature. All the aforementioned compounds were detected for the first time from this plant.