There
is growing interest in diffusion weighted (DW) MRI as a biomarker of
treatment response in metastatic and myeloma bone disease. We performed an
ROC analysis of normal vs myeloma involved marrow. Using an ADC threshold of
724 mm2s-1 x 10-6 the sensitivity and specificity for detecting myeloma
marrow involvement are 90 and 70% respectively. This threshold was applied to
a test case to produce segmented ADC maps which were used to predict
treatment response.