OTHER PROGRAM AFFILIATIONS

We combine x-ray crystallography and biophysics with molecular simulation to study the structure, folding and dynamics of proteins, with a particular focus on the design and engineering of proteins for medical and biotechnological application. Our team is a unique and exciting mix of experimentalists and computational biologists using modeling and simulation to make predictions that can be tested in the lab.

Smoothing of five hypothetical energy landscapes by consensus design. Five protein homologues exhibit differences in their energy landscapes, with three containing kinetic traps that present a propensity for misfolding. As the kinetic traps are not conserved across all five homologues, consensus design is capable of smoothing out the energy landscape to eliminate non-conserved features. Reproduced from Porebski and Buckle, Protein Eng Des Sel. 2016 Jul;29(7):245-51