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Hi 181, I suppose your key has a deactivating button for openning car and switching off alarms.
These cars are designed in such a way that once you lock with remote then you have to open with it. Else will triger alarm even close fule pump

Hi.
I have a clio II, 2001, i have the same problem and i fixed it.
Don't know if will work for you but here it goes:

1 - no key in ingnition
2 - press the unlock button in console off the car for about 10 seconds(dont let go)
3 - it should work the central doors one time and then 2 times( hear)
4 - press the remote a few times until it starts working

It worked for me hope the same for you.
Please tell me if it worked and pass the message.

Renault Laguna II Key Remote Control ProgrammingLAGUNA II INFRA RED RESYNCHRONISING1. Turn the Ignition OFF.2. Press the central door locking button for more than 5 seconds. Note: the door should lock then unlock.3. When this happens 15 seconds is allowed and the immobiliser warning light illuminates.4. Point the 1st key at the receiver and press the button once, the doors should lock and unlock.5. Point the 2nd key at the receiver and press the button once, the doors should lock and unlock.6. Check the remote control unlocks and locks the doors.