2007

Lowe was placed on 60-Day disabled list on April 1 and began a rehabilitation assignment on July 3 with the Triple-A Tacoma Rainiers. He also made rehab appearances for the Short Season Everett AquaSox and the West Tenn Diamond Jaxx before being activated on July 24, He was 0–0, with a 6.75 ERA in four relief appearances, during his seven rehab appearances in West Tennessee, Everett and Tacoma. He was optioned to Tacoma on August 9 to make room on the roster for John Parrish. He was recalled from Tacoma and placed on 15-day DL on August 28. He was rated by Baseball America as the Mariners number 8 prospect heading into the 2008 season.

2008–2009

In 2008 Lowe set career-highs in games (57), innings (63.2), and strikeouts (55). Among Mariners relievers, he ranked second in games, third in innings and third in strikeouts. He was 0–2, with a 3.60 ERA at home, the 6th-lowest home ERA by a reliever in the American League. He began the season by making 12 scoreless relief appearances in his first 13 games. Lowe recorded a 0.55 ERA by allowing just one run in 16.1 innings from March 31 to June 13. He tossed at least 2 innings in 12 of his 57 appearances.

He recorded his first Major League save April 11 against the Los Angeles Angels.[2] Lowe was optioned to Tacoma on August 25, but did not make an appearance. He was recalled on September 2.

2011

Lowe was included on the Rangers postseason roster for 2011 after posting an ERA of 3.80 in 52 games. He was on the mound when David Freese hit the walk off home run to end game 6 of the 2011 World Series.

2012

He appeared in 36 games in 2012, with a 3.43 ERA.

Los Angeles Angels

On February 8, 2013, he signed a minor league contract with the Los Angeles Dodgers that included an invitation to spring training. The Dodgers released him on March 24 and he signed another minor league contract, this time with the Los Angeles Angels on March 27.[4] He was designated for assignment on May 29, and released on June 6.

Washington Nationals

Tampa Bay Rays

Lowe signed a minor league deal with the Tampa Bay Rays on November 20, 2013. He was released on March 26, 2014.

Cleveland Indians

Lowe signed a minor league deal with the Cleveland Indians in April 2014. He was called up to the majors from the Triple-A Columbus Clippers on May 22. He was designated for assignment on July 8,[6] and assigned outright to Columbus on July 12. Lowe elected free agency on October 12, 2014.[7]

Seattle Mariners

On December 18, 2014, the Seattle Mariners signed Lowe to a minor league contract with an invitation to spring training. Before he was traded, Lowe had pitched 36 innings in 34 appearances out of the bullpen for the Mariners, with an ERA of 1.00.

Toronto Blue Jays

On July 31, 2015, Lowe was traded to the Toronto Blue Jays for Rob Rasmussen, Jacob Brentz, and Nick Wells.[8] Over the last two months of 2015, Lowe pitched 19 innings of relief for Toronto, compiling a 3.79 ERA. His combined totals for 2015 (with Seattle and Toronto) were: 55 innings, 1–3 record, 13 games finished, and a 1.96 ERA.

Detroit Tigers

On December 8, 2015, the Detroit Tigers signed Lowe to a two-year, $11 million contract.[9] Lowe struggled in his first season with the Tigers, pitching to a 7.11 ERA in 491⁄3 innings.