The last piece of NBC's big talk-show turnover will fall into place Monday when Seth Meyers debuts as host of “Late Night.”

Meyers, who until early this month was a “Saturday Night Live” veteran and co-anchor of its “Weekend Update” newscast, is filling the vacancy left by Jimmy Fallon after five years hosting “Late Night.”

Based in New York (as is the newly relocated “Tonight”), “Late Night with Seth Meyers” airs at 12:35 a.m. EST/11:35 p.m. CST, with a roster of scheduled guests for its premiere including Vice President Joe Biden, Meyers' former “Weekend Update” desk mate, Amy Poehler and the band A Great Big World.

Another “SNL” alum, Fred Armisen, will be on hand as Meyers' resident bandleader.

So far the late-night changes are paying off. Riding the crest of NBC's Olympics coverage, “The Tonight Show Starring Jimmy Fallon” was seen by an average of 8.5 million viewers in its first week, the biggest “Tonight” audience in decades.

Can the 40-year-old Meyers make the most of his popular lead-in?

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He comes to his new role as a talk-show host with demonstrated skill and appeal from his years as an “SNL” writer and performer.

He is known as cerebral with a taste for topical humor, a TV star who doesn't hog the spotlight and enjoys playing the straight man. And while he has conceded that interviewing guests will be a new experience for him, off-camera he is quick-witted and comfortable engaging in lively conversation.

Other potential pluses: Meyers' executive producer is Lorne Michaels, the comedy kingpin whose empire also includes “SNL” and “Tonight.” And his producer is Michael Shoemaker, who stewarded Fallon's successful “Late Night” stint.

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