Bubble fusion is the common name for a nuclear fusion reaction hypothesized to occur during sonoluminescence, an extreme form of acoustic cavitation[?]. The high temperatures produceable through sonoluminescence raises the possibility that it might be a means to achieve thermonuclear fusion.

Rusi P. Taleyarkhan[?] (ORNL) and colleagues reported in March 8, 2002 issue of the peer-reviewed journal Science, that acoustic cavitation experiements conducted with deuteratedacetone show measurements of tritium and neutron output that is consistent with fusion. Shock wave simulations seem to indicate that the temperatures inside the collapsing bubbles may reach up to 10 million degrees Kelvin - as hot as the center of the sun. However, all of the above measurements have not been confirmed and are highly debated, recalling the 1989 cold fusion fiasco. Although the apparatus operates in a room temperature environment, this is not strictly cold fusion, as the claimed nuclear reactions would be occurring at the very high temperatures in the core of the imploding bubbles.

The researchers used a pulse of neutrons in order to nucleate (i.e. "seed") the tiny bubbles, whereas most previous experiments start with small air bubbles already in the water. Using this new method, the team was able to produce stable bubbles that could expand to nearly a millimeter in radius before collapsing. In this way, the researchers stated, they were able to create the conditions necessary to produce very high pressures and temperatures.

A rebuttal by Taleyarkhan and the other authors of the original report claimed that the Shapira and Saltmarsh report failed to account for significant differences in experimental setup, including over an inch of shielding between the neutron detector and the sonoluminescing acetone. Taleyarkhan et al. report that when these differences are properly accounted for, the Shapira and Saltmarsh results are consistent with fusion.