Milton Taylor, Indiana University, offers an easy-to-read and fascinating text describing the impact of viruses on human society. The book starts with an analysis of the profound effect that viral epidemics had on world history resulting in demographic upheavals by destroying total populations. It also provides a brief history of virology and immunology. Furthermore, the use of viruses for the treatment of cancer (viral oncolysis or virotherapy) and bacterial diseases (phage therapy) and as vectors in gene therapy is discussed in detail. Several chapters focus on viral diseases such as smallpox, influenza, polio, hepatitis and their control, as well as on HIV and AIDS and on some emerging viruses with an interesting story attached to their discovery or vaccine development. The book closes with a chapter on biological weapons. It will serve as an invaluable source of information for beginners in the field of virology as well as for experienced virologists, other academics, students, and readers without prior knowledge of virology or molecular biology.

The analysis of recurrences in dynamical systems by using recurrence plots and their quantification is still an emerging field. Over the past decades recurrence plots have proven to be valuable data visualization and analysis tools in the theoretical study of complex, time-varying dynamical systems as well as in various applications in biology, neuroscience, kinesiology, psychology, physiology, engineering, physics, geosciences, linguistics, finance, economics, and other disciplines. This multi-authored book intends to comprehensively introduce and showcase recent advances as well as established best practices concerning both theoretical and practical aspects of recurrence plot based analysis. Edited and authored by leading researcher in the field, the various chapters address an interdisciplinary readership, ranging from theoretical physicists to application-oriented scientists in all data-providing disciplines.

These proceedings comprise 60 refereed papers of the Seventh World Congress on Engineering Asset Management (WCEAM) that was held in Deajeon City, Korea from 8-9 October 2012. The material is a compilation of state-of-the-art papers in the field covering a comprehensive range of subjects that are equally relevant to business managers and engineering professionals alike. Proceedings of the 7th World Congress on Engineering Asset Management (WCEAM 2012): Towards Integration and Interoperability in EAM covers a wide range of topics in the discipline of engineering asset management, including: · strategic asset management · condition monitoring and diagnostics · integrated intelligent maintenance · sensors and devices · information quality & management; · sustainability in asset management · asset performance and knowledge management · data mining and AI techniques in asset management · engineering standards and · education in engineering asset management. The breadth and depth of these proceedings will make them an excellent resource for asset management practitioners, researchers and academics, as well as undergraduate and postgraduate students in tertiary institutions and in industry.

This book is designed to meet the needs of all orthodontists interested in treating children, adolescents, and/or adults with brackets placed on the palatal and lingual surfaces of the teeth. It explains how to achieve excellent results, comparable to those obtained with labial brackets, by means of techniques performed entirely within the dental office and avoiding use of expensive outside laboratories. The book is divided into three parts. The first is devoted to biomechanics, considering each type of malocclusion and describing how to prepare the arches optimally. This is not a theoretical section; rather it covers aspects acknowledged to be of prime practical importance by students and doctors. The second part explains how to treat the most common malocclusions, with step-by-step descriptions of techniques used in everyday clinical practice. The concluding part of the book describes finishing procedures to enhance aesthetics and discusses long-term results.

Scala is a new programming language developed by Martin Odersky and his team at the EPFL. The name Scala is derived from Sca(lable) La(nguage). Scala is a multi-paradigm language, incorporating object oriented approaches with functional programming. Although some familiarity with standard computing concepts is assumed (such as the idea of compiling a program and executing this compiled form, etc. ) and with basic procedural language concepts (such as variables and allocation of values to variables) the early chapters of the book do not assume any familiarity with object orientation nor functional programming. These chapters also step through other concepts with which the reader may not be familiar (such as list processing). From this background, John Hunt provides a practical introduction to object and functional technology using Scala, one of the newest and most interesting programming languages available. A variety of concepts are introduced through practical experience taking the reader beyond the level of the language syntax to the philosophy and practice of object-oriented development and functional programming. Students, and those actively involved in the software industry will find this comprehensive introduction to Scala and to object orientation and functional programming, invaluable.

The purpose of this book is to provide an integrated course in real and complex analysis for those who have already taken a preliminary course in real analysis. It particularly emphasises the interplay between analysis and topology. Beginning with the theory of the Riemann integral (and its improper extension) on the real line, the fundamentals of metric spaces are then developed, with special attention being paid to connectedness, simple connectedness and various forms of homotopy. The final chapter develops the theory of complex analysis, in which emphasis is placed on the argument, the winding number, and a general (homology) version of Cauchy's theorem which is proved using the approach due to Dixon. Special features are the inclusion of proofs of Montel's theorem, the Riemann mapping theorem and the Jordan curve theorem that arise naturally from the earlier development. Extensive exercises are included in each of the chapters, detailed solutions of the majority of which are given at the end. From Real to Complex Analysis is aimed at senior undergraduates and beginning graduate students in mathematics. It offers a sound grounding in analysis; in particular, it gives a solid base in complex analysis from which progress to more advanced topics may be made.

It is a comprehensive and well illustrated textbook on all aspects of tsunami. I don't think there is any other book on the topic published. As one bookseller said after the Indian Ocean tsunami event, "I would have just filled my front window with copies and they would have walked out the store. " This statement was just as relevant after the Japanese tsunami of 2011 and will be as relevant when the next large tsunami event happens, sooner rather than later. The book can be used by a student or layperson to gain encyclopedic knowledge about tsunami.

This book introduces the basic concepts of real and functional analysis. It presents the fundamentals of the calculus of variations, convex analysis, duality, and optimization that are necessary to develop applications to physics and engineering problems. The book includes introductory and advanced concepts in measure and integration, as well as an introduction to Sobolev spaces. The problems presented are nonlinear, with non-convex variational formulation. Notably, the primal global minima may not be attained in some situations, in which cases the solution of the dual problem corresponds to an appropriate weak cluster point of minimizing sequences for the primal one. Indeed, the dual approach more readily facilitates numerical computations for some of the selected models. While intended primarily for applied mathematicians, the text will also be of interest to engineers, physicists, and other researchers in related fields.

This volume explores the use of mass spectrometry for biomedical applications. Chapters focus on specific therapeutic areas such as oncology, infectious disease and psychiatry. Additional chapters focus on methodology as well as new technologies and instrumentation. This volume provides readers with a comprehensive and informative manual that will allow them to appreciate mass spectrometry and proteomic research but also to initiate and improve their own work. Thus the book acts as a technical guide but also a conceptual guide to the newest information in this exciting field. Mass spectrometry is the central tool used in proteomic research today and is rapidly becoming indispensable to the biomedical scientist. With the completion of the human genome project and the genomic revolution, the proteomic revolution has followed closely behind. Understanding the human proteome has become critical to basic and clinical biomedical research and holds the promise of providing comprehensive understanding of human physiological processes. In addition, proteomics and mass spectrometry are bringing unprecedented biomarker discovery and are helping to personalize medicine.

New concepts arise in science when apparently unrelated fields of knowledge are put together in a coherent way. The recent results in molecular biology allow to explain the emergence of body patterns in animals that before could not be understood by zoologists. There are no "fancy curiosities" in nature. Every pattern is a product of a molecular cascade originating in genes and a living organism arises from the collaboration of these genes with the outer physical environment. Tropical fishes are as startling in their colors and geometric circles as peacocks. Tortoises are covered with the most regular triangles, squares and concentric circles that can be green, brown or yellow. Parallel scarlet bands are placed side by side of black ones along the body of snakes. Zebras and giraffes have patterns which are lessons in geometry, with their transversal and longitudinal stripes, their circles and other geometric figures. Monkeys, like the mandrills, have a spectacularly colored face scarlet nose with blue parallel flanges and yellow beard. All this geometry turns out to be highly molecular. The genes are many and have been DNA sequenced. Besides they not only deal with the coloration of the body but with the development of the brain and the embryonic process. A precise scenario of molecular events unravels in the vertebrates. It may seem far-fetched, but the search for the origin of this geometry made it mandatory to study the evolution of matter and the origin of the brain. It turned out that matter from its onset is pervaded by geometry and that the brain is also a prisoner of this ordered construction. Moreover, the brain is capable of altering the body geometry and the geometry of the environment changes the brain. Nothing spectacular occurred when the brain arrived in evolution. Not only it came after the eye, which had already established itself long ago, but it had a modest origin. It started from sensory cells on the skin that later aggregated into clusters of neurons that formed ganglia. It also became evident that pigment cells, that decide the establishment of the body pattern, originate from the same cell population as neurons (the neural crest cells). This is a most revealing result because it throws light on the power that the brain has to rapidly redirect the coloration of the body and to change its pattern. Recent experiments demonstrate how the brain changes the body geometry at will and within seconds, an event that could be hardly conceived earlier. Moreover, this change is not accidental it is related to the surrounding environment and is also used as a mating strategy. Chameleons know how to do it as well as flat fishes and octopuses. No one would have dared to think that the brain had its own geometry. How could the external geometry of solids or other figures of our environment be apprehended by neurons if these had no architecture of their own? Astonishing was that the so called "simple cells", in the neurons of the primary visual cortex, responded to a bar of light with an axis of orientation that corresponded to the axis of the cell''s receptive field. We tend to consider our brain a reliable organ. But how reliable is it? From the beginning the brain is obliged to transform reality. Brain imagery involves: form, color, motion and sleep. Unintentionally these results led to unexpected philosophical implications. Plato''s pivotal concept that "forms" exist independently of the material world is reversed. Atoms have been considered to be imaginary for 2,000 years but at present they can be photographed, one by one, with electron microscopes. The reason why geometry has led the way in this inquiry is due to the fact that where there is geometry there is utter simplicity coupled to rigorous order that underlies the phenomenon where it is recognized. Order allows variation but imposes at the same time a canalization that is patent in what we call evolution.

This richly illustrated and comprehensive case-based atlas documents the MR findings observed in spondyloarthritis and offers guidance on selection of the appropriate imaging protocol, which is critical in detecting the potentially very subtle changes. The presented MR study protocols include T2-weighted sequences with fat saturation and contrast-enhanced T1-weighted sequences with fat saturation, these being sequences which permit better visualization of inflammatory changes of both anterior and posterior elements of the spine. Cases of spondylitis, discitis, osteoarthritis and sacroiliitis are described and concise information is provided on the clinical history of the rheumatic diseases. The inclusion of a large number of high-resolution images ensures that the atlas will serve as a guide to differentiation between potentially confounding diseases and an aid to early diagnosis, which has become essential with the advent of new treatments in the field of spondyloarthritis (TNF inhibitors). In addition to radiologists, neuroradiologists, rheumatologists, orthopedists and physiatrists will greatly benefit from the contents of this volume and its thorough presentation of the rheumatic diseases.

The methods considered in the 7th conference on "Finite Volumes for Complex Applications" (Berlin, June 2014) have properties which offer distinct advantages for a number of applications. The second volume of the proceedings covers reviewed contributions reporting successful applications in the fields of fluid dynamics, magnetohydrodynamics, structural analysis, nuclear physics, semiconductor theory and other topics. The finite volume method in its various forms is a space discretization technique for partial differential equations based on the fundamental physical principle of conservation. Recent decades have brought significant success in the theoretical understanding of the method. Many finite volume methods preserve further qualitative or asymptotic properties, including maximum principles, dissipativity, monotone decay of free energy, and asymptotic stability. Due to these properties, finite volume methods belong to the wider class of compatible discretization methods, which preserve qualitative properties of continuous problems at the discrete level. This structural approach to the discretization of partial differential equations becomes particularly important for multiphysics and multiscale applications. Researchers, PhD and masters level students in numerical analysis, scientific computing and related fields such as partial differential equations will find this volume useful, as will engineers working in numerical modeling and simulations.

This book presents a gradual path toward "educating" readers in understanding how Control Systems truly operate and in recognizing, simulating and improving them in all fields of activity. Starting from the hypothesis that knowledge of Control Systems is not only a technical fact but also represents a discipline - that is, "A discipline is a developmental path for acquiring certain skills or competencies. (. . . ) To practice a discipline is to be a lifelong learner. You "never arrive"; you spend your life mastering disciplines. " (Senge, 2006, p. 10) - Piero Mella has set the objective of making Control Systems a topic that is, in a certain sense, simple and attractive by turning to the effective symbolism typical of Systems Thinking models and avoiding too technical and formal a treatment of the subject. Thus readers should know that this is not an engineering, physics, biology or economics text, nor a mathematics one either. Technical or mathematical tools are not necessary to construct Control Systems; instead the book adopts a highly simple and universal logic behind the notion itself of control process and the simple and universal action of the Control Systems that produce this process. The Magic Ring: Systems Thinking Approach to Control Systems is divided into 10 chapters. Chapter 1 seeks to review the basic language of Systems Thinking and the models it allows us to create, while Chapter 2 introduces the control process, presenting the theoretical structure of four simple Control Systems we all can observe and manage. In Chapter 3 a general typology of Control Systems is proposed with examples taken from observations of reality. The view of Control Systems is broadened in Chapter 4 by introducing two important generalizations: 1. multi lever Control Systems, with levers that are independent or dependent of each other; 2. multi-objective systems, with independent or interdependent objectives. Chapter 5 outlines the guidelines for recognizing, observing or designing Control Systems and presents the problems that arise regarding their logical realization, introducing the fundamental distinction between symptomatic and structural control. Chapters 6-9 undertake a "mental journey" through various "environments", increasingly broader in scope, suggesting to the reader how to recognize therein Control Systems that, by their ubiquitous presence, make the world possible in all its manifestations. Finally Chapter 10 covers ideas about a Discipline of Control Systems and the human aspects of control.

This book addresses the key concerns regarding the operation of wind turbines in cold climates and focuses in particular on the analysis of icing and methods for its mitigation. Topics covered include the implications of cold climates for wind turbine design and operation, the relevance of icing for wind turbines, the icing process itself, ice prevention systems and thermal anti-icing system design. In each chapter, care is taken to build systematically on the basic knowledge, providing the reader with the level of detail required for a thorough understanding. An important feature is the inclusion of several original analytical and numerical models for ready computation of icing impacts and design assessment. The breadth of the coverage and the in-depth scientific analysis, with calculations and worked examples relating to both fluid dynamics and thermodynamics, ensure that the book will serve not only as a textbook but also as a practical manual for general design tasks.

This book covers the main mathematical and numerical models in computational electrocardiology, ranging from microscopic membrane models of cardiac ionic channels to macroscopic bidomain, monodomain, eikonal models and cardiac source representations. These advanced multiscale and nonlinear models describe the cardiac bioelectrical activity from the cell level to the body surface and are employed in both the direct and inverse problems of electrocardiology. The book also covers advanced numerical techniques needed to efficiently carry out large-scale cardiac simulations, including time and space discretizations, decoupling and operator splitting techniques, parallel finite element solvers. These techniques are employed in 3D cardiac simulations illustrating the excitation mechanisms, the anisotropic effects on excitation and repolarization wavefronts, the morphology of electrograms in normal and pathological tissue and some reentry phenomena. The overall aim of the book is to present rigorously the mathematical and numerical foundations of computational electrocardiology, illustrating the current research developments in this fast-growing field lying at the intersection of mathematical physiology, bioengineering and computational biomedicine. This book is addressed to graduate student and researchers in the field of applied mathematics, scientific computing, bioengineering, electrophysiology and cardiology.

The 3rd edition of Controlling Radiated Emissions by Design has been updated to reflect the latest changes in the field. New to this edition is material on aspects of technical advance, specifically long term energy efficiency, energy saving, RF pollution control, etc. This book retains the step-by-step approach for incorporating EMC into every new design, from the ground up. It describes the selection of quieter IC technologies, their implementation into a noise-free printed circuit layout, and the gathering of all these into low radiation packaging, including I/O filtering, connectors and cables considerations. All guidelines are supported by thorough and comprehensive calculated examples. Design engineers, EMC specialists and technicians will benefit from learning about the development of more efficient and economical control of emissions.

The International Multidisciplinary Microscopy Congress (INTERM2013) was organized on October 10-13, 2013. The aim of the congress was to bring together scientists from various branches to discuss the latest advances in the field of microscopy. The contents of the congress have been broadened to a more "interdisciplinary" scope, so as to allow all scientists working on related subjects to participate and present their work. These proceedings include 39 peer-reviewed technical papers, submitted by leading academic and research institutions from over 12 countries and representing some of the most cutting-edge research available. The 39 papers are grouped into the following sections: - Applications of Microscopy in the Physical Sciences - Applications of Microscopy in the Biological Sciences

NASA's Mercury astronauts were seven highly skilled professional test pilots. Each of them seemed to possess the strength of character and commitment necessary to overcome apparently insurmountable obstacles as the United States entered into a Cold War space race with the Soviet Union. This was never more evident than on the epic suborbital MR-4 flight of Liberty Bell 7 with astronaut Virgil ('Gus') Grissom piloting the spacecraft to a successful splashdown, followed by the premature blowing of the craft's explosive hatch. After a hurried exit and struggling to stay afloat, he could only watch helplessly as the recovery helicopter pilot valiantly fought a losing battle to save the sinking capsule. That day NASA not only lost a spacecraft but came perilously close to losing one of its Mercury astronauts, a decorated Korean fighter pilot from Indiana who might one day have soared to the highest goal of them all, as the first person to set foot on the Moon. For the first time, many of those closest to the flight of Liberty Bell 7 and astronaut Gus Grissom offer their stories and opinions on the dramatic events of July 21, 1961, and his later pioneering Gemini mission. They also tell of an often controversial life cut tragically and horrifically short in a launch pad fire that shocked the nation.

This book provides a rigorous framework in which to study problems in the analysis, stability and design of networked control systems. Four dominant sources of difficulty are considered: packet dropouts, communication bandwidth constraints, parametric uncertainty, and time delays. Past methods and results are reviewed from a contemporary perspective, present trends are examined, and future possibilities proposed. Emphasis is placed on robust and reliable design methods. New control strategies for improving the efficiency of sensor data processing and reducing associated time delay are presented. The coverage provided features: · an overall assessment of recent and current fault-tolerant control algorithms; · treatment of several issues arising at the junction of control and communications; · key concepts followed by their proofs and efficient computational methods for their implementation; and · simulation examples (including TrueTime simulations) to provide hands-on experience. In addition to the theoretical coverage, the author describes a number of applications that demonstrate the real-world relevance of this material, and these include: · a servo system; · a triple inverted pendulum; · power system control; · wireless control of a cart with inverted pendulum and wireless servo application with emphasis on controller area networks; and · switched ethernet and wireless area networks. Researchers and graduate students working in networked and distributed control will find this text a useful guide in avoiding and ameliorating common and serious problems with these systems. The increasing prevalence of networks in many fields of engineering will make Control and Estimation Methods over Communication Networks of interest to practitioners with backgrounds in communications, process engineering, robotics, power, automotive and other areas.

The Billionaire's Christmas Gift by Carole MortimerNick Steele's heart is closed to everyone but his daughter. He will do anything to make this Christmas special for his little girl, though sharing the holidays with her impossibly attractive teacher wasn't at all what he had planned. But the lovely and vibrant Ms. Beth Morgan soon has Nick rethinking his own wish list. Might there be room for one more special lady in his life?One Christmas Night in Venice by Jane PorterFive years ago a car accident killed her husband and unborn child-or so Diane Mayer had thought. Then she sees Dominic Coducci alive and well before her eyes, looking as shocked as she! Dom is determined to put his family back together, whatever it takes. But Diane needs to be sure about her husband's feelings before she can share his bed again.Snowbound with the Millionaire by Catherine GeorgeGeorgia had no intention of spending her Christmas marooned with a sexy millionaire. She wanted to be alone, to lick her wounds and nurse her broken heart. But Chance-her gorgeous rescuer-was making it difficult for Georgia to concentrate on her misery! Though a snowstorm raged outside the mansion, inside things were quickly heating up....

Safe, steady...and unsatisfying--that pretty much summed up Maggie Stanton's life. Until a stranger stirred her imagination until she blushed, a stranger who made Maggie do the unimaginable: take a risk....Shockingly, the man who'd compelled her to forsake predictability for passion was the full-grown version of her childhood best friend. Only, this Matthew Stone wanted marriage, not a walk down memory lane.For a while, Maggie almost believed that their whirlwind wedding was the union of soul mates. Almost. Then she learned the secret Matthew was keeping.

This book collects innovative research presented at the 17th Conference of the Association of Geographic Information Laboratories for Europe (AGILE) on Geographic Information Science, held in 2014 in Castellón, Spain. The scientific papers cover a variety of fundamental research topics as well as applied research in Geospatial Information Science, including measuring spatiotemporal phenomena, crowdsourcing and VGI, geosensor networks, indoor navigation, spatiotemporal analysis, modeling and visualization, spatiotemporal decision support, digital earth and spatial information infrastructures. The book is intended for researchers, practitioners, and students working in various fields and disciplines related to Geospatial Information Science and technology.

This volume contains the proceedings from the conference "The Labyrinth of Star Formation" that was held in Crete, Greece, in June 2012, to honour the contributions to the study of star formation made by Professor Anthony Whitworth of Cardiff University. The book covers many aspects of theoretical and observational star formation: low-mass star formation; young circumstellar discs; computational methods; triggered star formation; the stellar initial mass function; high-mass star formation and stellar clusters. Each section starts with a review paper, followed by papers discussing recent theoretical and observational work. This volume summarises our current understanding of star formation and is useful for both graduate students and researchers alike.

For the efficient utilization of energy resources and the minimization of environmental damage, thermoelectric materials can play an important role by converting waste heat into electricity directly. Nanostructured thermoelectric materials have received much attention recently due to the potential for enhanced properties associated with size effects and quantum confinement. Nanoscale Thermoelectrics describes the theory underlying these phenomena, as well as various thermoelectric materials and nanostructures such as carbon nanotubes, SiGe nanowires, and graphene nanoribbons. Chapters written by leading scientists throughout the world are intended to create a fundamental bridge between thermoelectrics and nanotechnology, and to stimulate readers' interest in developing new types of thermoelectric materials and devices for power generation and other applications. Nanoscale Thermoelectrics is both a comprehensive introduction to the field and a guide to further research, and can be recommended for Physics, Electrical Engineering, and Materials Science departments.

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