This series features Dr. G working on unexplained deaths in the Orlando area, as well as similar deaths from her last position as a Medical Examiner in Bexar County, Texas. The shows feature dramatic re-enactments of the events leading up to the person's death as well as the autopsies. Also interviews of Dr. G, family members, and other people connected to the deaths are shown.

The unexplained death cases that Dr. G works on can come from a variety of factors, such as undiagnosed medical conditions, accidents, or foul play. In one instance, a woman who attempted suicide died a few days after her attempt. Dr. G found that her death was actually due to another condition and was not by her own hand. Another instance dealt with human bones that had been found by railroad tracks. Through an autopsy and investigative work it was discovered that the remains were those of a missing girl who had been killed by her mother.

New Episodes

The fifth season began airing on Monday, September 29, 2008 at 9PM (eastern) on Discovery Health Channel, on which date the show also relocated to the Monday at 9:00 PM time slot. The show had previously aired in the Friday at 9PM (eastern) time slot for most of its run.