Sent in by Alec
When selecting your plays for offense or defense, hold the R button and
the play you want to have and this lets you choose the play above, or
hold Z and the play you want to have lets you choose the play below.
You can choose up to nine plays now. This way, no one can see which
play you are doing.

Sent in by Alec
If you know that the computer or person that you are playing against will
be trying to get their next play off fast, simply run down the field and
get away from the other players at the end of a play. When the other
team lines up for their next play, your player will still be running back.
The opposing team is not allowed to call hike until you get back, allowing
the clock to run out further or even the game. This is great to keep the
other team from kicking a crucial field goal or just to make your friends mad.

Sent in by Alec at The Unofficial World of Nintendo!!!
This glitch involves the quarterback throwing the football. If you watch
every single passing play you will notice that right after the quarterback
lets go of the ball the ball will rotate 360 degrees vertically before
heading out to the receiver. What this means is that the ball will not
do a spin, but a summersault. You can also see something similar to this
on field goals.