Fox said he and producers didn't take a calculated strategy to how they would deal with his Parkinson's on the show. There were no "pie charts," no discussions over how to couch it.

"I just thought I'm going to do this and let it be what it is," he said. " ... Sometimes it's frustrating. Sometimes it's funny."

This publicity image released by NBC shows actor Michael J. Fox from the "The Michael J. Fox Show" panel during the NBCUniversal Press Tour in Beverly Hills, Calif., on Saturday, July 27, 2013. Fox will star as Mike Henry, a former local NBC newscaster with Parkinson's. (AP Photo/NBC, Chris Haston)

His much-publicized comeback vehicle, "The Michael J. Fox Show" contains several parallels to the actor's real-life trajectory. He plays a beloved TV anchor man who put his career on hold to spend more time with his family and focus on his health after he was diagnosed with Parkinson's.

But now five years later, with the kids busy growing up and Mike growing restless, he's returning to the airwaves.

Fox said that guest appearances on shows like "The Good Wife," "Rescue Me" and others in recent years convinced him that he was ready to get back to TV on a full-time basis.

"They really brought me to a place that this is what I'm built and programmed to do," he said. "Why can't I? There's no reason not to do it."

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And now that he's back, Fox is quickly getting into the groove again.

"I'm rebuilding the muscles," he said. "I'm getting more comfortable with the schedule every day."

Fox does admit, however, that he has to pace himself a bit differently than he did when he was acting on "Family Ties."

"But I say to (his wife) Tracy, that's just being old. That's not Parkinsons, it's being 52."

Fox said he doesn't rule out having members of his own family come on the show. In fact, Pollan, has already shot a guest appearance for a future episode.