We noted you are experiencing viewing problems

Check with your IT department that JWPlatform, JWPlayer and Amazon AWS & CloudFront
are not being blocked by your network.
The relevant domains are *.jwplatform.com,
*.jwpsrv.com, *.jwpcdn.com,
jwpltx.com, jwpsrv.a.ssl.fastly.net,
*.amazonaws.com and *.cloudfront.net.
The relevant ports are 80 and 443.

Share This Lecture

Email

Social

Permalink

You are viewing a talk that is a part of one of our comprehensive courses. Additional learning material: case studies, projects, workshops and recommended reading; multiple choice questions and suggested exam questions with model answers are available on application.
Learn more

Transcript

Choose Transcript Language:

0:00

So this is the second lecture on current denguevaccine development,
and in the first lecturewe described the vaccine
under current development,and exactly where they are
in the development process.Now we're going to talk about
how are we going to implementthese vaccines, how we're going
to use them, and what problemscan we expect, and how
can they be solved.So problems to be solved.

0:27

And these are the topics that
we'll discuss in this lecture.First, when will dengue
vaccines come online?Second, what are the global
dengue vaccine needs?Third, what are the
complexities thatwe're going to have to confront
with, as we've seen, a Sanofi,which is just a partially
efficacious vaccine,it's not a 100% against
all four viruses.How are we going to immunize the
two distinctly different groupswho are at risk to dengue disease?And how can we stop or
reduce dengue transmission?Fourth, how can dengue
vaccines be improved?And here we need to understand
the complication of antibodydependent enhancement,
abbreviated ADE,and to understand better
how protection is inducedagainst dengue
infection and disease,both in the natural setting,
and also from vaccines.And here we're going to need
greater attention to and supportfrom basic research, and finally,
the use of a human challenge modelin which human beings
who have been vaccinatedwill actually be challenged
by a live, somewhat modifieddengue virus.