Before Using

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of tacrolimus injection in children with liver transplants.

Appropriate studies have not been performed on the relationship of age to the effects of tacrolimus injection in children with kidney and heart transplants. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of tacrolimus injection in the elderly. However, elderly patients are more likely to have kidney, liver, or heart problems, which may require caution and an adjustment in the dose for patients receiving tacrolimus injection.

Pregnancy

Information about this tacrolimus-intravenous-route

Pregnancy Category

Explanation

All Trimesters

C

Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

Amifampridine

Dronedarone

Mifepristone

Nelfinavir

Pimozide

Piperaquine

Posaconazole

Ziprasidone

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Aceclofenac

Acemetacin

Adalimumab

Afatinib

Alefacept

Amikacin

Amiloride

Amiodarone

Amtolmetin Guacil

Anagrelide

Aripiprazole

Artemether

Aspirin

Atazanavir

Bacillus of Calmette and Guerin Vaccine, Live

Basiliximab

Bedaquiline

Blinatumomab

Bromfenac

Bufexamac

Buserelin

Carbamazepine

Caspofungin

Celecoxib

Ceritinib

Choline Salicylate

Cisplatin

Citalopram

Clarithromycin

Clonixin

Clozapine

Colchicine

Crizotinib

Cyclosporine

Dabrafenib

Darunavir

Delamanid

Deslorelin

Dexibuprofen

Dexketoprofen

Dibekacin

Diclofenac

Diflunisal

Dipyrone

Domperidone

Efavirenz

Eliglustat

Enzalutamide

Erythromycin

Escitalopram

Eslicarbazepine Acetate

Esomeprazole

Etodolac

Etofenamate

Etoricoxib

Etravirine

Felbinac

Fenoprofen

Fepradinol

Feprazone

Floctafenine

Flufenamic Acid

Fluoxetine

Flurbiprofen

Foscarnet

Fosphenytoin

Gentamicin

Gonadorelin

Goserelin

Haloperidol

Histrelin

Ibuprofen

Ibuprofen Lysine

Idelalisib

Iloperidone

Indomethacin

Infliximab

Itraconazole

Ivabradine

Kanamycin

Ketoconazole

Ketoprofen

Ketorolac

Lapatinib

Leuprolide

Lornoxicam

Loxoprofen

Lumefantrine

Lumiracoxib

Measles Virus Vaccine, Live

Meclofenamate

Mefenamic Acid

Meloxicam

Metronidazole

Mitotane

Morniflumate

Moxifloxacin

Mumps Virus Vaccine, Live

Nabumetone

Nafarelin

Naproxen

Nefazodone

Neomycin

Nepafenac

Netilmicin

Niflumic Acid

Nilotinib

Nimesulide

Omeprazole

Ondansetron

Oxaprozin

Oxyphenbutazone

Parecoxib

Pasireotide

Pazopanib

Phenobarbital

Phenylbutazone

Phenytoin

Piketoprofen

Piroxicam

Pixantrone

Poliovirus Vaccine, Live

Pranoprofen

Primidone

Proglumetacin

Propyphenazone

Proquazone

Quetiapine

Ranolazine

Rifabutin

Rifampin

Rofecoxib

Rotavirus Vaccine, Live

Rubella Virus Vaccine, Live

Salicylic Acid

Salsalate

Sevoflurane

Siltuximab

Sirolimus

Smallpox Vaccine

Sodium Salicylate

Spironolactone

St John's Wort

Streptomycin

Sulindac

Sunitinib

Telaprevir

Telithromycin

Tenofovir

Tenoxicam

Tiaprofenic Acid

Ticagrelor

Tizanidine

Tobramycin

Tocophersolan

Tolfenamic Acid

Tolmetin

Triamterene

Triptorelin

Typhoid Vaccine

Ulipristal

Valdecoxib

Vandetanib

Varicella Virus Vaccine

Vemurafenib

Vilanterol

Vinflunine

Voriconazole

Yellow Fever Vaccine

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Amprenavir

Boceprevir

Chloramphenicol

Clotrimazole

Dalfopristin

Danazol

Diltiazem

Ertapenem

Metoclopramide

Mibefradil

Nevirapine

Nifedipine

Quinupristin

Rifapentine

Ritonavir

Saquinavir

Schisandra sphenanthera

Theophylline

Tigecycline

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

Allergy to polyoxyl 60 hydrogenated castor oil—Should not be used in patients with this condition.

Diabetes or

Hyperkalemia (high potassium in the blood) or

Hypertension (high blood pressure) or

Myocardial hypertrophy (heart is larger than normal), history of or

Paresthesias (numbness or tingling in the hands, arms, legs, or feet), history of or