I love reading the history. It's hard to disentangle oneself from all the clinging vines and thickets that characterize today's Lyme and ME/CFS worlds. If you can dig up the kernels of deviance, you can see the thorn bushes for what they are, and more nimbly discern the pricks.

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Avoiding pricks tends to be a good idea. Difficult when you have ME - or Lyme by the look of it.

There are lots of references to Lyme in the thread. You can find them using the standard PR search facility - just type in 'lyme' and select 'search this thread only'. This is the first mention I found that way.

There are lots of references to Lyme in the thread. You can find them using the standard PR search facility - just type in 'lyme' and select 'search this thread only'. This is the first mention I found that way.

Abstract
Myalgic encephalomyelitis/chronic fatigue syndrome is an unexplained debilitating disorder that is frequently associated with cognitive and motor dysfunction. We analyzed cerebrospinal fluid from 32 cases, 40 subjects with multiple sclerosis and 19 normal subjects frequency-matched for age and sex using a 51-plex cytokine assay. Group-specific differences were found for the majority of analytes with an increase in cases of CCL11 (eotaxin), a chemokine involved in eosinophil recruitment. Network analysis revealed an inverse relationship between interleukin 1 receptor antagonist and colony-stimulating factor 1, colony-stimulating factor 2 and interleukin 17F, without effects on interleukin 1α or interleukin 1β, suggesting a disturbance in interleukin 1 signaling. Our results indicate a markedly disturbed immune signature in the cerebrospinal fluid of cases that is consistent with immune activation in the central nervous system, and a shift toward an allergic or T helper type-2 pattern associated with autoimmunity.

"Our results indicate a markedly disturbed immune signature in the cerebrospinal fluid of cases that is consistent with immune activation in the central nervous system, and a shift toward an allergic or T helper type-2 pattern associated with autoimmunity." - Sexy.

"Our results indicate a markedly disturbed immune signature in the cerebrospinal fluid of cases that is consistent with immune activation in the central nervous system, and a shift toward an allergic or T helper type-2 pattern associated with autoimmunity." - Sexy.

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This allergic component was exciting to me as well when I read it. I will be interested in just what this is and it's affects and how they relate - it's been quite serious for me this last year and it's got to a level of feeling quite destructive.

This allergic component was exciting to me as well when I read it. I will be interested in just what this is and it's affects and how they relate - it's been quite serious for me this last year and it's got to a level of feeling quite destructive.

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Yep! I read somewhere that there is a higher portion of allergies in ME-patients compared to controls, fits with me as i have a big allergy towards grass.

Started with the usual allergies to grass pollen etc years ago and have graduated to more and different allergies--my cats, some foods.
Although none of these are serious so far only mild to moderate.

I get the impression though that allergies aren't all that uncommon in the general (and otherwise healthy) population.
And although I do have allergies I have never considered them anything like a main symptom until recently they seem to be moving up the queue.

The posts starting at post 306 and ending with 319 were originally in the thread titled 'New Hornig/Lipkin paper in Molecular Psychiatry'. The posts were merged into this thread as they both are about the same study.