This is a quite vague question unless you state elaborate on your motivation for writing the book and any possible restrictions.
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N.N.Sep 9 '11 at 8:57

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There are no restrictions except that the book has to be some reasonable size (not 1000 or 10 pages) and that I'd like to listen to the audience. - I know that this is vague but I am sure the answers will make it less vague.
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topskipSep 9 '11 at 9:00

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Is it precisely that book announced by OpenSourcePress for July 2011? In case yes, would you mind to inform the publisher about the remote possibility of a short delay? I've been curious about the book for monthes and now?
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Keks DoseSep 9 '11 at 10:50

Is the book targeted towards a specific macro package, or is it indifferent to macro packages? Certain tasks (for example fonts as some of the answers suggest) are very different across macro packages.
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AdityaSep 12 '11 at 4:17

Well, it is more targeted towards plain and LaTeX. Perhaps I'll have an "excursion into ConTeXt" chapter.
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topskipSep 12 '11 at 6:26

What added value LuaTeX offers (what is possible or easier than with
pdflatex, xetex, xelatex, ...) and how best to achieve the
benefits. (Why should I move?)

Same question but with pre-processing and post-processing tools (e.g.
for image preparation, PSTricks, importing pdf pages, bibliographies, citations, indexing). (Will "x" still work as it does now? If not, how best do I achieve it the same or a better result?)

Can fonts and font tools that are designed for/with TeX and LaTeX
still be used, e.g. Computer Modern bitmap fonts, virtual fonts,
commercial fonts such as Lucida and MTPro, EPS images, pdf pages).
(Partly this is extending Raphink's point on font management
comparison with XeTeX to include TeX and PDFLaTeX)
(Can I still use font y or glyph z?)

The basic working set: do I have everything I need if I have the current TeX Live?

Finally, is your book aimed at first-time users of (Any)TeX or at users migrating from other already familiar with, and using, another member of the TeX and friends family?

Because of UTF-8 and fontspec, LuaTeX is attractive to those who work with languages and literature. This means that we’ll be looking for ways around babel where it’s only “partially working” (p. 13 of Manuel Pégourié-Gonnard’s A guide to LuaLaTeX). Paul Isambert’s article on French punctuation (pp. 87–100 of the current issue of Cahiers Gutenberg) is an example of the kind of thing we need to know about, but while I follow most of his discussion, we non-programmers could use some help applying it, and also making sure it doesn’t apply to any non-French parts of a document. And what do we do with Greek? I’ve found, by trial and error, that I should just type the Greek and not enclose it in \textgreek{}, but what about hyphenation and the like?

As for fonts, I’m now happily using Adobe Jenson Pro and other favorites for which I was pining, but although I’m accustomed to reviewing log files for warnings about missing characters, with LuaTeX I find that missing characters are silently skipped. So I’ve taken to proofreading the output more closely and examining each font in FontForge to make sure that it contains every accented character required by my text, but maybe there’s something to be explained here?

I'd warmly welcome a chapter or two that guides users of latex2e (mostly pdflatex these days, right?) along the path they'll have to take to adapt the code of their existing documents so that they'll compile under lua(la)tex. For instance, if they've been using some font packages (say, mathpazo or mathptmx), how will they have to change their setup to make it compile in lualatex?