• both diurnal and nocturnal spontaneous locomotor activities are reduced compared to controls; significant recovery is seen upon injection of 150 mg/kg of dopamine precursor L-DOPA, whereas this dose does not affect non-transgenic controls

• striatal dopamine, DA, and the dopamine metabolite homovanillic acid, HVA are reduced to ~49% and ~52% relative to controls; content of another metabolite, DOPAC, is reduced similarly in 8 week old mice

• ~45% of dopaminergic neurons in the substantia nigra pars compacta, SNc, with the lateral part particularly affected, compared to non-transgenic littermates at 8 weeks of age or in transgnic mice expressing full-length mutant alpha-synuclein; considerable loss of neuronal cell bodies in the SNc region is observed

• striatal dopamine, DA, and the dopamine metabolite homovanillic acid, HVA are reduced to ~49% and ~52% relative to controls; content of another metabolite, DOPAC, is reduced similarly in 8 week old mice