Childhood is a very tender but superb stage of human life. The effect on physical development and mental status of this period has its effect over rest of life. In day to day paediatric practice, paediatricians come across a good number of patients suffering from diseases related to gastrointestinal tract. The common symptoms of gastrointestinal tract disorder include abdominal pain, bowel disturbances (like diarrhoea, constipation), nausea, vomiting, abdominal distension, anorexia, chronic flatulence and failure to thrive due to disturbed digestion. Grahani Dosha is a disease entity related with gastrointestinal disorders, to which children are more vulnerable. It gives rise to number of long term as well short term complications from an aemia to failure to thrive, which can hamper the overall growth of child. In the present study 52 patients were registered and randomly divided into two groups. In Group A - Rajanyadi Vati (treated group) and Group B - Bhunimbadi Vati (standard control group) was given for 4 weeks. The etiological factors, sign & symptoms were observed carefully to elucidate the Samprapti (etio pathogenesis) of the disease. The effect of the therapy in both the group was assessed by a specially prepared proforma. In Group A (Rajanyadi Vati) 68.18% of patients were moderately improved, whereas in Group B, Bhunimbadi Vati showed mild improvement in 75% patients.