In the first decade of the 21st Century on Earth, the rising of the population results in low quality of life, as well the increasing number of ESP incidents and alien invasions. At Nebula M-78, the information service of the Space Defense Force watches these phenomena and throughout the Space Security Service, a ramification of the group sent a warrior to Earth named Ultraman Neos and his commander Ultra Seven 21. Upon arriving on Earth, Ultraman Neos secretly merges with Genki Kagura to help HEART (Hi-tech Earth Alert Rescue Team) fight monsters both of terrestrial and extraterrestrial origin.