TOP
STORY

Scientists discovered that a subset of immune cells called nonclassical monocytes, previously unknown to reside in the lungs, play a key role in driving primary graft dysfunction, the leading cause of death after lung transplantation. [Press release from Northwestern University discussing online prepublication in Science Translational Medicine]
Press Release | Abstract

In a conditional Tp53;Rb1 mutant mouse model of SCLC, researchers demonstrated a requirement for the hedgehog ligand Sonic hedgehog (Shh) for the progression of SCLC. They showed that overexpression of cyclin B1 induced chromosomal instability in mouse embryonic fibroblasts lacking both Tp53 and Rb1. [Oncogene]
Full Article

Investigators analyzed integrated transcriptomics data and an shRNA library against glycolytic enzymes and found that elevated Aldolase A expression is highly correlated with metastatic potential and a poor prognosis in patients with NSCLC. Aldolase A silencing significantly suppressed metastatic potential both in vitro and in vivo, whereas the ectopic overexpression of Aldolase A resulted in the opposite phenotype. [Cancer Lett]
Abstract

Researchers found that flavonoids including kaempferol, chrysin, and luteolin concentration-dependently decrease claudin-2 expression in lung adenocarcinoma A549 cells. Promoter deletion assay using luciferase reporter vector showed that kaempferol and luteolin inhibited the function of transcriptional factor that binds to the region between -395 and -144 of claudin-2 promoter. The decrease in promoter activity was suppressed by mutation in signal transducers and activators of transcription (STAT)-binding site, which is located between -395 and -144. [Nutrients]
Full Article

The authors summarize recent findings regarding the role of EIF4F complex in NSCLC progression and targeted therapy potentials. They also discuss the unanswered questions and future directions in this field. [Oncotarget]
Full Article

Visit our
reviews
page to see a complete list of reviews in
the pulmonary cell research field.

OSE Immunotherapeutics SA announced that the company has entered into a multi-year research collaboration on OSE-703, a cytotoxic monoclonal antibody against the alpha chain of interleukin-7 receptor, with Memorial Sloan Kettering Cancer Center in New York. The goal of this research collaboration is to explore IL-7R directed immunotherapy OSE-703 for solid tumors with NSCLC as the primary cancer model. [OSE Immunotherapeutics SA]
Press Release

The University of Illinois College of Medicine launched a new center that focuses on understanding tissue regeneration and pioneering future developments in stem cell biology as a means to repair diseased organs and tissues. Researchers in the new center will investigate the molecular signals that drive stem cells to mature into different cell types, such as blood, heart and blood vessel cells. [University of Illinois]
Press Release

Texas Governor Greg Abbott signed a bill allowing clinics and companies in the state to offer people unproven stem cell interventions without the testing and approval required under federal law. Like the “right to try” laws that have sprung up in more than 30 states, the measure is meant to give desperately ill patients access to experimental treatments without oversight from the U.S. Food and Drug Administration. [ScienceInsider]
Editorial

Government agencies lack the funds to build platforms for data sharing and resist taking responsibility for such infrastructure. They may hope that universities will host data, but the development of institutional repositories is patchy, and to rely on them is effectively to discourage common data standards and curation. [Nature News]
Editorial

When the label “white male” is attached to a research grant application, do peer reviewers give it a better score? That’s the question psychologist Patricia Devine of the University of Wisconsin in Madison has spent the past four years, and more than $1 million from the National Institutes of Health (NIH) in Bethesda, Maryland, trying to answer with an unusual experiment. [ScienceInsider]
Editorial