Bottom Line:
The up- and down-regulated DEGs were mainly involved in functions like mitotic cell cycle and pathway like cell cycle.A total of seven transcription factors including forkhead box protein M1 (FOXM1) and 30 target genes were revealed in the transcription factor-target gene regulation network.Genes including CCNB1, CCNB2 and TOP2A, as well as transcription factors like FOXM1 might be used as the novel gene therapy targets for sepsis related ARDS.

Background: Acute respiratory distress syndrome (ARDS) is a potentially devastating form of acute inflammatory lung injury as well as a major cause of acute respiratory failure. Although researchers have made significant progresses in elucidating the pathophysiology of this complex syndrome over the years, the absence of a universal detail disease mechanism up until now has led to a series of practical problems for a definitive treatment. This study aimed to predict some genes or pathways associated with sepsis-related ARDS based on a public microarray dataset and to further explore the molecular mechanism of ARDS.

Conclusions: Pathways like mitotic cell cycle were closed related with the development of ARDS. Genes including CCNB1, CCNB2 and TOP2A, as well as transcription factors like FOXM1 might be used as the novel gene therapy targets for sepsis related ARDS.

Mentions:
The transcription factors of the top 35 genes with higher scores in Table 3 were predicted. With NES >4, a total of seven transcription factors [such as forkhead box protein M1 (FOXM1)] and 30 target genes [such as hyaluronan-mediated motility receptor (HMMR)] were revealed in the present regulatory network (Fig. 4).Fig. 4

Mentions:
The transcription factors of the top 35 genes with higher scores in Table 3 were predicted. With NES >4, a total of seven transcription factors [such as forkhead box protein M1 (FOXM1)] and 30 target genes [such as hyaluronan-mediated motility receptor (HMMR)] were revealed in the present regulatory network (Fig. 4).Fig. 4

Bottom Line:
The up- and down-regulated DEGs were mainly involved in functions like mitotic cell cycle and pathway like cell cycle.A total of seven transcription factors including forkhead box protein M1 (FOXM1) and 30 target genes were revealed in the transcription factor-target gene regulation network.Genes including CCNB1, CCNB2 and TOP2A, as well as transcription factors like FOXM1 might be used as the novel gene therapy targets for sepsis related ARDS.

Background: Acute respiratory distress syndrome (ARDS) is a potentially devastating form of acute inflammatory lung injury as well as a major cause of acute respiratory failure. Although researchers have made significant progresses in elucidating the pathophysiology of this complex syndrome over the years, the absence of a universal detail disease mechanism up until now has led to a series of practical problems for a definitive treatment. This study aimed to predict some genes or pathways associated with sepsis-related ARDS based on a public microarray dataset and to further explore the molecular mechanism of ARDS.

Conclusions: Pathways like mitotic cell cycle were closed related with the development of ARDS. Genes including CCNB1, CCNB2 and TOP2A, as well as transcription factors like FOXM1 might be used as the novel gene therapy targets for sepsis related ARDS.