Weitere Antikörper gegen ADRA2A Interaktionspartner

Study showed that alpha2A adrenergic receptors are highly expressed in the cell bodies and axons of mesoprefrontal dopaminergic neurons provides a morphological basis to the vast functional evidence that somatodendritic and nerve-terminal alpha2A adrenergic receptors control dopaminergic activity and dopamine release in the prefrontal cortex.

Results suggested that nicotine produces anxiogenic-like behaviors which may be mediated through a basolateral amygdala alpha2-adrenoceptor mechanism

The current study demonstrated that a physiological concentration of adrenaline attenuates insulin release via coupling of alpha2A-adrenoceptor to cAMP/TRPM2 signaling.

The study suggests that a2-adrenoreceptors/catecholamine play pivotal role in psychological stress-induced colitis.

This study showed that reduced expression of the alpha2A-adrenoceptor (Adra2a) which modulate antidepressant action in hippocampus.

Fzd5 and Trvp6 are expressed in the epithelial layer of the prospective pyroric and glandular stomach, respectively and Adra2a is expressed in the mesenchymal region of the stomach primordium at the beginning of morphogenesis.

The sympathetic hyperactivity present in alpha2A/alpha2C-ARKO mice alters vascular reactivity only in certain types of arteries

Our findings indicate that IC noradrenergic neurotransmission acting through activation of both alpha1- and alpha2-adrenoceptors has a facilitatory influence on pressor response to acute restraint stress.

Thus, our study reveals distinct actions of PBN afferents within the BNST and suggests that alpha(2A)-AR agonists may filter excitatory transmission in the BNST by inhibiting a component of the PBN input while enhancing the actions of other inputs.

The time course of Adra2a- and dopamine D2R-mediated transmission reflects underlying differences in the extent of spillover and pooling of inhibitory postsynaptic potentials (IPSPs).

Activation of alpha2A-AR and muscarinic M3 receptors affects the initial [Ca(2+)] response to increase of glucose from 3 to 20mM in BETA-cells.

Significant group*genotype interactions were found for 3 ADRA2A variants revealing steeper delay discounting (DD) in cocaine users (but not controls) carrying the G-allele of rs1800544, the T-allele of rs521674 and the C-allele of rs602618. High ADRA2A mRNA expression levels were significantly associated with a reduced tendency to choose smaller more immediate rewards in cocaine users.

The summary of this study, none of the examined variants reached the threshold for statistical significance after correction for multiple testing. The SNP rs1800544 in ADRA2A, revealed nominally significant association, but the direction of effect was the opposite to that reported in previous studies conducted in children and adolescents.

The results of this study suggested that ADRA2A rs3750625 contributes to poststress musculoskeletal pain severity by modulating miR-34a regulation

This study reveled that ADA2A are up regulate in peripheral blood mononuclear cells in patient with multiple sclerosis.

Results show that ADRA2A genetic variants are associated with blood glucose and stress-induced hyperglycemia after acute myocardial infarction in Caucasians.

These findings suggest that Gi1 interacts only with active GPCRs and that the well known high speed of GPCR signal transduction does not require preassembly between G proteins and GPCRs.

ADRA2A Germline Gene Polymorphism is Associated to the Severity, but not to the Risk, of Breast Cancer.

Risk alleles for 6 loci increased glucose levels from birth to 5 years of age (ADCY5, ADRA2A, CDKAL1, CDKN2A/B, GRB10, and TCF7L2

The ADRA2A C-1291G and COMT Val158Met genotypes and sex interact in predicting detection and perception of emotional valence in facial expressions

ADRA2a is associated with heart rate recovery after exercise.

Study is in line with previous reports of an association between ADRA2A gene variants and general reaction time variability during response selection tasks

Genetic association of ADRA2A single nucleotide polymorphism with metabolic syndrome and high level insulin among the Tatars

The rs10885122G>T polymorphism of the ADRA2A gene was not associated with type 2 diabetes mellitus in Euro-Brazilians, and carriers of the T allele had lower body weight in the presence of type 2 diabetes mellitus.

Common polymorphisms in the ADRA2A gene are not associated with orthostatic hypotension risk in Chinese.

Rabbit Adrenergic, alpha-2A-, Receptor (ADRA2A) Interaktionspartner

Proliferation of Achilles tenocytes in overuse tendinosis is induced by ADRA2A stimulation and inhibited by an ADRA2A blocker.

ADRA2A Antigen-Profil

Beschreibung des Gens

Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Studies in mouse revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons\; the alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes alpha2A subtype and it contains no introns in either its coding or untranslated sequences.