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Brain Windows

Brain Windows is a blog devoted to reporting, analyzing and interpreting the latest results in the field of brain imaging technologies, particularly at the levels of systems, circuits, single cells and below.

Why is this post inappropriate?

Trying to start a reboot of the posts here on Brain Windows. Lots of great stuff has come out since the last regular posting period, and unfortunately I don’t have the time to cover it all. One of the most exciting papers of the last few months was Rapid blue-light–mediated induction of protein interactions in [...]... Read more »

Why is this post inappropriate?

Nguyen et al demonstrate a mammalian cell based system for optically measuring ACh levels in an intact brain. They coexpressed M1 muscarinic receptors with the genetically-encoded calcium indicator TN-XXL in HEK293 cells. ACh binding to the M1 receptor induced IP3-mediated calcium influx. This calcium rise was then picked up by the TN-XXL and reported as a change in CFP/YFP fluorescence. The crazy part is that they took this cell culture assay and implanted the cells into the brains of livin........ Read more »

Why is this post inappropriate?

Inhibition has a powerful role shaping the network dynamics of the cortex, but most studies of inhibitory circuitry are done in brain slice or anesthetized animals. In Membrane potential dynamics of GABAergic neurons in barrel cortex of behaving mice, Gentet et al use two-photon imaging to guide dual, whole-cell patch clamp of inhibitory and excitatory neurons in the mouse barrel cortex. ... Read more »

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