DTPA (pentetic acid) Disease Interactions

Pentetic Acid (Includes DTPA) ↔ Renal Dysfunction

Moderate Potential Hazard, Moderate plausibility

Applies to: Renal Dysfunction

The image quality obtained with Technetium Tc 99m pentetate may be adversely affected by impaired renal function. Literature reports indicate that the target to non-target ratio for intracranial lesions may take several hours to develop fully, thus the possibility of missing certain lesions when imaging is restricted to the early period after injection should be recognized.

Technetium Tc 99m conjugates (e.g., bicisate, exametazime, pentetate) are often eliminated by the kidney, and the risk of toxic reactions to these drugs may be greater in patients with impaired renal function. Dosage adjustments have not been studied in patients with renal and/or hepatic impairment. Caution is advised when used in these patients.

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.

Major

Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.

Moderate

Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.

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How to Prevent Deadly Drug Interactions

Some mixtures of medications can lead to serious and even fatal consequences.