AbstarctIn the present study Meprobamate solid dispersions were formulated. The standard curve of Meprobamate was obtained and good correlation was obtained with R2 value 0f 0.999.the medium selected was pH 6.8phosphate buffer.Meprobamate was mixed with various proportions of excipients showed no colour change at the end of two months, proving no drug-excipient interactions.The precompression blend of Meprobamate soild dispersions were characterized with respect to angle of repose, bulk density, tapped density, Carr’s index and Hausner’s ratio. Theprecompression blend of all the batches indicating good to fair flowability and compressibility. Solid dispersions were prepared with various concentrations of carriers, the prepared solid dispersions were compressed into tablets by using rotary tablet punching machine, and 8 mm punch, with the hardness of 2.5kg /cm2.The formulated tablets were evaluated for various quality control parameters. The tablets were passed all the tests. Among all the formulations F1 formulation containing, Drug and Peg 4000 in the ratio of 1:0.25 showed good result that is 94.95 % in 50 minutes. As the concentration of polymer increases the drug release was decreased. While the formulations containing PEG 6000 showed less release. Hence from the dissolution data it was evident that F1 formulation is the better formulation.Keywords: Meprobamate, solid dispersions, PEG 4000, PEG 6000.

AbstractTransdermal route offers several potential advantages over conventional routes. These advantages includes avoidance of first pass metabolism, predictable and extended duration of action, minimizing undesirable side effects, utility of short half-life drugs, improving physiological and pharmacological response, avoiding the fluctuation in the blood levels, and most important it provides patient convenience. Becaplermin (brand name Regranex) is a cicatrizant, available as a topical gel. Regranex is a human platelet-derived growth factor indicated along with good wound care for the treatment of lower extremity diabetic neuropathic ulcers.In the present work an attempt was being made to formulate and evaluate Transdermal gel containing anti fungal drug Becaplermin. Carbopol 971, Sodium CMC and carbopol 934 were selected as polymers. The drug and excipient compatability was studied by using FTIR Nine formulations of gels were prepared by taking different quantities of polymers. The prepared gel was subjected to various evaluation tests like pH, spreadability, viscosity, content uniformity and diffusion studies conducted upto 12hrs.All the results were within the limits , by diffusion studies it was observed that formulation F7 shown maximum drug release of 95.49% which was considered as optimized formulation.Key words: Becaplermin, Transdermal, Carbopol 971, Sodium CMC and carbopol 934

AbstractThe present study was aimed to formulate fast dissolving tablets of Dofetilide. In the present work Sodium starch glycollate, Cross povidone and Cross carmellose sodium were employed as super disintegrating agents to enhance the solubility and dissolution rate of selected drug molecule. All the formulations were prepared by direct compression method using 6mm punch on 8 station rotary tablet punching machine. The blend of all the formulations showed good flow properties such as angle of repose, bulk density, tapped density. The prepared tablets were shown good post compression parameters and they passed all the quality control evaluation parameters as per I.P limits. Among all the formulations F4 formulation showed maximum % drug release i.e., 98.16 % in 30 min hence it is considered as optimized formulation. The F4 formulation contains Cross povidone as super disintegrate in the concentration of 5 mg. Keywords: Dofetilide, Oro dispersible tablets, Super disintegrating agents, Direct compression

AbstractIn the present work, an attempt has been made to develop fast disintegrating tablets of Daclatasvir dihydrochloride. In the present work Solutab, Polyplasdone XL and Explotab were employed as super disintegrating agents to enhance the solubility and dissolution rate of selected drug molecule. Camphor was employed as sublimating agent, due to presence of camphor maximum pores will be formed. As the number of pores were more the body fluid will penetrates more easily. All the formulations were prepared by direct compression method using 8mm punch on 8 station rotary tablet punching machine. The blend of all the formulations showed god flow properties such as angle of repose, bulk density, tapped density. The prepared tablets were shown good post compression parameters and they passed all the quality control evaluation parameters as per I.P limits. Among all the formulations F8 formulation showed maximum % drug release i.e., 99.23% in 30 min hence it is considered as optimized formulation. The F8 formulation contains Explotab as super disintegrate in the concentration of 20 mg.Keywords: Daclatasvir dihydrochloride, Sublimating agent , camphor, Solutab, PolyplasdoneXL and Explotab.

ABSTARCTIn the present work an attempt was being made to formulate and evaluate topical gel containing anti inflammatory drug Apremilast. Carbopol 971, Sodium CMC and carbopol 934 were selected as polymers. The drug and excipient compatability was studied by using FTIR. Nine formulations of gels were prepared by taking different quantities of polymers. The prepared gel was subjected to various evaluation tests like pH, spreadability, viscosity, content uniformity and diffusion studies conducted upto 12hrs. All the results were within the limits, by diffusion studies it was observed that formulation F8 shown maximum drug release of 95.49% which was considered as optimized formulation. Key words: Apremilast, Topical, Carbopol 971, Sodium CMC and carbopol 934

Abstract In the present work an attempt was being made to formulate and evaluate ganciclovir proliposomal gel. Phosphatidyl choline, Cholesterol and mannitol were used as excipients in the preparation of proliposomes. The prepared proliposomes were tested for drug release F2 formulation shown maximum drug release which is considered as the optimized formulation. Gel formulation was prepared by taking different quantities of gellan gum. To the prepared gel formulations the optimized proliposomes were incorporated and then diffusion studies were conducted to the gel formulations to know the in-vitro drug release. Formulation F3 shown maximum drug release hence it was considered as optimized formulationKeywords: Ganciclovir, Proliposomal gel

AbstractHerbal medicines are considered to offer gentle means of managing chronic diseases at a lower cost. Trigonellafoenum graecum. (Gammalu in Sinhala) leaves have been used as antidiabetic remedies in many cultures for thousands of years. The aim of this review is to address the existing evidence on antidiabetic effects of the Trigonellafoenumgraecum. The hypoglycaemic effects, antidyslipidaemic effects, antioxidative effects and the safety of the Trigonellafoenum graecumleaves have been scientifically validated using a multitude of in vitro and in vivo studies. Multiple -cell regeneration, insulinbmechanisms responsible for hypoglycaemic effects of Trigonellafoenum graecum including release and insulin-like actions of some compounds isolated were identified. (-)-Epicatechin, a -cell regeneration andbflavonoid isolated from the leaves has shown insulin-like effects, effects on insulin release. Several compounds including pterostilbene and marsupsin isolated from the Trigonellafoenum graecum leaves were identified as compounds with hypoglycaemic effects. The latex (gum) of the tree is a popular remedy used in Sri Lanka for diabetes even though the literature on Trigonellafoenumgraecum does not discuss about the antidiabetic effects of the latex. Few investigations focused on the antidiabetic effects of Trigonellafoenumgraecum latex have demonstrated strong inhibitory effects of the latex on α-amylase and α-glucosidase activities and on protein glycation. Investigations focusing on the antidiabetic effects and possible toxicity of the Trigonellafoenumgraecum are essential to validate its efficacy and safety.Keywords: anti diabetic, neuropathy, trigonellafoenum

AbstractMajor complication of hyperlipidemia are atherosclerotic heart disease, heart attack and heart stroke, but atherosclerosis is primary cause of death. Developing countries are reliant on medicinal plants as their main source of treatment for diseases. As Apiumgraveolens have the native habitat the production is more so it is locally available cost effective with no side effects.AsApiumgraveolens is cost effective and beneficiary in metabolism of cholesterol22, so it has been taken in to consideration in order “To evaluate Anti-hyperlipidemic activity of Methanolic Extract and Phenolic Extracts of Apiumgraveolens in triton X -100 induced hyperlipidemic rats and also to evaluate the cardioprotective activity of the respective extracts.and the final results showed that this plant shows the hyperlipidemic activity and also shows minimal side effects towards the liver and cardiac muscle tissues.Key words: Apiumgraveolens, hyperlipidemic activity, cardio protective.

AbstarctIn the present research work colon formulation of Olsalazine targeted to colon by using various polymers developed. To achieve pH-independent drug release of Olsalazine, pH modifying agents (buffering agents) were used. Colon targeted tablets were prepared in two steps. Initially core tablets were prepared and then the tablets were coated by using different pH dependent polymers. Ethyl cellulose, Eudragit RLPO and S100 were used as enteric coating polymers. The precompression blend of all formulations was subjected to various flow property tests and all the formulations were passed the tests. The tablets were coated by using polymers and the coated tablets were subjected to various evaluation techniques. The tablets were passed all the tests. Among all the formulations F6 formulation was found to be optimized as it was retarded the drug release up to 18 hours and showed maximum of 98.45% drug release. It followed first order kinetics mechanism.Keywords: Olsalazine, Colon targeted drug delivery system, Ethyl cellulose, Eudragit RLPO, Eudragit S100

ABSTRACTThe proposed HPLC method was found to be simple, specific, precise, accurate, rapid and economical for simultaneous estimation of Lamivudine and Raltegravir in tablet dosage form. The developed method was validated in terms of accuracy, precision, linearity, robustness and ruggedness, and results will be validated statistically according to ICH guidelines. The Sample recoveries in all formulations were in good agreement with their respective label claims. From literature review and solubility analysis initial chromatographic conditions Mobile phase ortho phosphoric acid buffer: Acetonitrile 40:60 were set (Buffer PH 2.45 adjusted with Triethylamine), Symmetry C18 (250×4.6mm, 5µ) Column, Flow rate 1.0 ml/min and temperature was ambient, eluent was scanned with PDA detector in system and it showed maximum absorbance at 260 nm. As the methanol content was increased Lamivudine and Raltegravir got eluted with good peak symmetric properties. The retention times for Lamivudine and Raltegravir was found to be 2.335 min and 3.400 min respectively. System suitability parameters were studied by injecting the standard five times and results were well under the acceptance criteria. Linearity study was carried out between 50% to150 % levels, R2 value was found to be as 0.999. By using above method assay of marketed formulation was carried out, 100.7% was present. Full length method was not performed; if it is done this method can be used for routine analysis of Lamivudine and Raltegravir.Keywords: HPLC, Ortho Phosphoric Acid, Acetonitrile, Symmetry C18, Lamivudine, Raltegravir