BACKGROUND: The centrosomal protein, TAX1 binding protein 2 (TAX1BP2) was first identified as a cellular interacting partner of HTLV-I virus oncoprotein, TAX1. Further investigation has shown that TAX1BP2 was targeted by TAX1 to induce supernumerary centrosome in TAX1-expressing cells. Recently, TAX1BP2 was found to be frequently underexpressed in hepatocellular carcinoma (HCC) and underexpression of TAX1BP2 suppressed the activation of tumor suppressor p53 in a p38 MAPK dependent manner, suggesting that TAX1BP2 is a putative tumor suppressor in HCC. Here we provide ...

BACKGROUND: The centrosomal protein, TAX1 binding protein 2 (TAX1BP2) was first identified as a cellular interacting partner of HTLV-I virus oncoprotein, TAX1. Further investigation has shown that TAX1BP2 was targeted by TAX1 to induce supernumerary centrosome in TAX1-expressing cells. Recently, TAX1BP2 was found to be frequently underexpressed in hepatocellular carcinoma (HCC) and underexpression of TAX1BP2 suppressed the activation of tumor suppressor p53 in a p38 MAPK dependent manner, suggesting that TAX1BP2 is a putative tumor suppressor in HCC. Here we provide ...

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eng

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WIN 2015 Symposium.

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7th WIN Symposium

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