Children:

Use lowest effective dose for shortest duration. Oral soln: use calibrated measuring device; dilute each dose in ½ glass of water. Individualize. Initially 1.1–1.8mg/kg up to adult dose every 3–4 hours as needed. If pain relief inadequate with ≤600mg/day, taper dose and discontinue; use alternative. Concomitant phenothiazines, other tranquilizers: reduce dose by 25–50%. Concomitant use or discontinuation of CYP2B6/CYP3A4 inhibitors or inducers: monitor closely and consider dose adjustments (see full labeling). Withdraw gradually by 25–50% every 2–4 days.

Contraindications:

Significant respiratory depression. Acute or severe bronchial asthma in an unmonitored setting or in the absence of resuscitative equipment. Known or suspected GI obstruction, including paralytic ileus. During or within 14 days of MAOIs.