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Escort in Shulan Current Genomics 12.5 2011 371378. PMC. Web. 19 Dec. 2016.Vitamin C ascorbic acid plays important roles as an antioxidant and in collagen synthesis. These important roles and the relatively large amounts of vitamin C required daily likely explain why most vertebrate species are able to synthesize this compound. Surprisingly many species such as teleost fishes anthropoid primates guinea pigs as well as some bat and Passeriformes bird species have lost the capacity to synthesize it. Here we review the genetic bases behind the repeated losses in the ability to synthesize vitamin C as well as their implications. In all cases so far studied the inability to synthesize vitamin C is due to mutations in the Lgulonolactone oxidase GLO gene which codes for the enzyme responsible for catalyzing the last step of vitamin C biosynthesis. The bias for mutations in this particular gene is likely due to the fact that losing it only affects vitamin C production. Whereas the GLO gene mutations in fish anthropoid primates and guinea pigs are irreversible some of the GLO pseudogenes found in bat species have been shown to be reactivated during evolution. The same phenomenon is thought to have occurred in some Passeriformes bird species. Interestingly these GLO gene losses and reactivations are unrelated to the diet of the species involved. This suggests that losing the ability to make vitamin C is a neutral trait.Bnhegyi GborCsala MiklsBraun LszlGarz Tams and Mandl JzsefFEBS Letters 381 doi 10.10160014579396000774 1996Ascorbic acid and glutathione are involved in the antioxidant defense of the cell. Their connections and interactions have b

Emo girls sex chatting 1 individuals localized mainly in spleen but not in thymus. CD94.1expressing blood cells in the urochordate Botryllus schlosseri might be ancestral NK cells they mediate cytotoxic lesion at the point of contact between colonies.NK gene complex NKC is on human chromosome 12p1319q13.4 evolved by gene duplication together with FcaR gene 15 haplotypes 100 genotypes diversity at the KIR locus has been generated by an evolutionary history of expansion and contraction presumably due to combinations of duplication and unequal crossing over within the locus. Up to 12 KIR genes appear to be expressed and KIR haplotypes consist of various combinations of KIR genes. The number of putatively expressed KIR genes present on a single haplotype ranges from 7 to 11 depending primarily on the presence or absence of activating KIR loci. Estimates of the extent of KIR genotype diversity within the population suggest that far 0.24 of unrelate

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