Packaging, Storage & Formulations

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Buffer

PBS (pH 7.2)

Preservative

0.05% Sodium Azide

Concentration

1.0 mg/ml

Purity

Immunogen affinity purified

Alternate Names for c-Fos Antibody

activator protein 1

AP-1

cellular oncogene c-fos

Cellular oncogene fos

cFos

c-Fos

FBJ murine osteosarcoma viral (v-fos) oncogene homolog (oncogene FOS)

FBJ murine osteosarcoma viral oncogene homolog

FOS

G0/G1 switch regulatory protein 7

G0S7

proto-oncogene c-Fos

v-fos FBJ murine osteosarcoma viral oncogene homolog

Background

The v-Fos oncogene was initially identified as the transforming gene of two independent murine osteosarcoma virus isolates and an avian nephroblastoma virus. The cellular homolog, c-Fos, encodes a nuclear phosphoprotein that is rapidly and transiently induced by a variety of agents and functions as a transcriptional regulator for several genes. In contrast to c-Jun proteins, which form homo- and heterodimers which bind to specific DNA TPA response elements (TREs), c-Fos proteins are only active as heterodimers with members of the Jun gene family. Murine Fos B encodes a nuclear protein of 338 amino acids which has 70% homology with c-Fos, exhibits similar kinetics of expression as c-Fos and forms heterodimers with both c-Jun and Jun B, which bind to TRE DNA response elements. Functional homologs of c-Fos and Fos B include Fra-1 and Fra-2 genes.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Video Protocols

WB Video Protocol

FAQs for c-Fos Antibody (NB100-91772). (Showing 1 - 1 of 1 FAQ).

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