Ultimate control technology for induciblecDNA or microRNA expression in mammalian cells

Cumate Inducible Lentivectors

The Cumate Switch Inducible System

The SparQ™ cumate switch lentivectors work through virus transduction and deliver extremely tight control, robust induction and a highly titratable expression switch for inducible gene and microRNA expression studies. The system works through the CymR repressor that binds the cumate operator sequences (CuO) with high affinity. The repression is alleviated through the addition of Cumate, a non-toxic small molecule that binds to CymR. This system has a dynamic inducibility, can be finely tuned and is reversible and inducible over and over for timed expression studies.