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2015年3月20日星期五

Berger's Disease and Recurrence of ESRD after Transplant

Kidney transplant is a very suitable alternative for people with Berger's
Disease that develop into ESRD. Overall success rates are as good or better than
those in other primary glomerular diseases. Unfortunately, the disease recurs in
the majority of renal grafts and may sometimes result in failed transplant.
ESRD caused by Berger's Disease
Berger disease tend to progress slowly, and about 50 percent of patients do
enter into end-stage renal disease within 25 years. So it is a significant
contributor to the incidence of ESRD in many countries. Transplant is the
treatment of choice for individuals with progressive renal failure due to IgA
Nephropathy.
Recurrence of Berger's Disease after transplantation
The frequency of histologic or clinically significant recurrence of IgAN
varies in the reported materials, with the incidence possibly increasing as a
function of time from transplantation.
Recurrent deposition of IgA may lead to many manifestations, ranging from an
incidentally noted histologic finding to mesangioproliferative
glomerulonephritis related to blood and protein in the urine and progressive
kidney dysfunction. IgA deposition may appear alone or be concurrent with other
problems such as chronic rejection.
In most cases, histologic recurrence, with or without evidence of clinical
disease can be seen. Once a study that reviewed biopsies from 29 allografts,
histologic recurrence of IgA deposition was found in 17 patients (58%). 3 cases
had a normal urine test and normal glomeruli, while 5 cases had hematuria, heavy
proteinuria, high blood pressure, and progressive kidney failure due to Berger's
Disease alone. The predictor for recurrence was a longer time after transplant
(46 versus 15 months in those without recurrence).

Faced with the great challenge of Berger's Disease relapse after renal
transplantation, patients always suffer a lot. However, in other cases, patients
with ESRD caused by this disease have successfully avoid a transplant with
natural treatment to significantly improve the kidney function. It has come true
for them to live a fully normal life. If you are interested to know more about
this, email us to kidney-treatment@hotmail.com for further contact.

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