Received June 25, 2018
The current issue is dedicated to the studies of neurodegenerative
diseases and memory. Molecular mechanisms and mutant genes have already
been revealed for many neurodegenerative diseases. However, in many
cases the cause of selective death of neurons in different brain
regions remains unclear. Genetic predisposition and aging are well
established risk factors in many neurodegenerative diseases. A large
body of evidence has been obtained that shows an important role of
immune factors in the modulation of neurodegenerative processes. The
progress in the treatment of neurodegenerative diseases requires new
cell models for identification of non-canonical pharmacological targets
and development of approaches for memory regulation. Gene therapy
technologies based on genome editing and RNA interference methods are
among promising approaches for repairing primary molecular defects
underlying neurodegenerative pathologies.
KEY WORDS: neurodegeneration, mutant genes, aging, memory,
Alzheimer’s disease