Alka-Seltzer Plus Cold And Cough (Aspirin / Chlorpheniramine / Dextromethorphan / Phenylephrine) is good for multiple cold symptoms, but it's more medicine than you need if you only have one symptom.

Relieves cold and flu symptoms, and helps you sleep.

Alka-Seltzer Plus Night Severe Cold And Flu (Acetaminophen / Doxylamine / Dextromethorphan / Phenylephrine) is good for multiple cold symptoms at night, but it's more medicine than you need if you only have one symptom.

Upsides

Alka-Seltzer Plus Cold And Cough (Aspirin / Chlorpheniramine / Dextromethorphan / Phenylephrine) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have a stuffy nose, a cough, fever, and pain.

Phenylephrine (the decongestant ingredient) has fewer side effects than other decongestants like pseudoephedrine. It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.

Dextromethorphan (the cough suppressant ingredient) works well and has very few side effects.

Alka-Seltzer Plus Night Severe Cold And Flu (Acetaminophen / Doxylamine / Dextromethorphan / Phenylephrine) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have a stuffy nose, a cough, fever, and pain.

The decongestant (phenylephrine) has fewer side effects than other decongestants. It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.

The cough medicine (dextromethorphan) works well and has very few side effects.

The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than other pain medications like aspirin or ibuprofen.

The antihistamine (doxylamine) can help you sleep.

Downsides

If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.

Phenylephrine doesn't last as long as other decongestants like pseudoephedrine.

You shouldn't use it if you have high blood pressure.

The aspirin in Alka-Seltzer Plus Cold And Cough (Aspirin / Chlorpheniramine / Dextromethorphan / Phenylephrine) interacts with many other drugs and health conditions.

If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.

Phenylephrine doesn't last as long as other decongestants like pseudoephedrine.

You shouldn't use it if you have high blood pressure.

To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.