Latest News for: rhodopsin

This is particularly difficult for the visual pigment rhodopsin, a GPCR activated by light, for which hundreds of mutations have been linked to inherited degenerative retinal diseases such as retinitis pigmentosa (RP) ... We combine this novel assay for rhodopsin light-dependent ......

Inherited retinal degenerations are caused by mutations in >250 genes that affect photoreceptor cells or the retinal pigment epithelium and result in vision loss. For autosomal recessive and X-linked retinal degenerations, significant progress has been achieved in the field of gene therapy as evidenced by the growing number of clinical... ....

Box jellyfish and vertebrates are separated by >500 million years of evolution yet have structurally analogous lens eyes that employ rhodopsin photopigments for vision ... In vertebrate rhodopsins, the molecular evolution of the... ....

Here conformational substates of the GPCRrhodopsin are investigated in micelles of dodecyl maltoside (DDM) and in phospholipid nanodiscs by monitoring the spatial positions of transmembrane helices 6 and 7 at the cytoplasmic surface using site-directed spin labeling... ....

Here, we describe two insights into the role of receptor conformational dynamics during agonist release (all-trans retinal, ATR) from the visual G protein-coupled receptor (GPCR) rhodopsin. First, we show that, after light activation, ATR can continually release and rebind to any receptor remaining in an active-like conformation. As with other... ....

The study of rhodopsin - the molecule that allows the eye to detect dim light - has a long and well-recognized history of more than 100 years ...Rhodopsin, on the other hand, has one subunit, thus making it difficult to distinguish rhodopsin monomers from rhodopsin dimers, in vivo....

For the first time, researchers have demonstrated the most likely configuration of rhodopsin in a living organism, and hope this discovery will help develop future therapies for retinitis pigmentosa, a degenerative eye disease for which there is no known cure ... ....