Farino went to the United States in 2004 to work for HBO, and directed the majority of episodes of the first three seasons of Entourage. He stayed to work on the series Big Love and Rome, and has received four Emmy and three DGA nominations. He was executive producer and director of the HBO television show How to Make It in America for its two series. In 2010, Farino directed The Oranges starring Hugh Laurie and Leighton Meester, his first feature film in the US. The movie premiered at the Toronto Film Festival and was released on October 5, 2012. Farino is based in Los Angeles, where he lives with his wife, actress Branka Katić, and their two sons, Louis and Joe.