GREMLIN Results:
Residue pairs sorted by strength in covariance:Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

i

j

Raw Score

Scaled Score

11_D

258_S

1.04794

3.534

287_H

290_N

0.92285

3.112

54_A

285_L

0.9018

3.041

13_I

286_A

0.87702

2.957

142_Q

155_F

0.85195

2.873

253_K

257_E

0.84686

2.856

75_N

97_T

0.83756

2.824

3_L

7_Q

0.80761

2.723

11_D

15_N

0.80147

2.703

123_R

151_I

0.79906

2.695

250_D

254_K

0.77024

2.597

55_V

71_A

0.74242

2.504

287_H

291_R

0.73685

2.485

12_E

254_K

0.73261

2.470

249_E

253_K

0.70413

2.374

322_E

327_R

0.6989

2.357

145_L

150_G

0.67869

2.289

320_S

327_R

0.65235

2.200

142_Q

146_R

0.63954

2.157

39_A

63_S

0.63388

2.138

157_S

172_K

0.62199

2.097

7_Q

11_D

0.62126

2.095

10_I

282_V

0.61983

2.090

286_A

290_N

0.61977

2.090

256_K

270_E

0.61731

2.082

33_C

38_F

0.60725

2.048

12_E

279_Y

0.6041

2.037

20_L

23_I

0.58175

1.962

282_V

286_A

0.5668

1.911

311_Q

314_K

0.56432

1.903

117_K

148_R

0.54945

1.853

122_T

181_R

0.54507

1.838

30_F

45_C

0.54107

1.825

125_S

154_A

0.53045

1.789

320_S

329_S

0.52986

1.787

154_A

157_S

0.5274

1.778

280_D

323_G

0.52368

1.766

12_E

283_Y

0.52345

1.765

114_D

148_R

0.50867

1.715

139_D

143_D

0.50657

1.708

144_L

147_E

0.50586

1.706

6_V

282_V

0.49316

1.663

109_A

113_V

0.49154

1.658

313_L

317_R

0.48573

1.638

315_Y

318_N

0.47588

1.605

13_I

283_Y

0.46586

1.571

12_E

16_N

0.46271

1.560

146_R

151_I

0.46022

1.552

128_Y

158_V

0.45666

1.540

250_D

253_K

0.45193

1.524

198_A

201_E

0.44995

1.517

143_D

147_E

0.44994

1.517

35_D

38_F

0.44699

1.507

84_T

105_D

0.44344

1.495

287_H

319_V

0.44132

1.488

4_A

7_Q

0.43814

1.477

10_I

27_V

0.43524

1.468

58_P

67_V

0.43411

1.464

199_A

204_M

0.41978

1.416

121_W

181_R

0.41621

1.403

123_R

179_G

0.41486

1.399

121_W

182_V

0.41092

1.386

99_F

317_R

0.41001

1.383

5_A

278_A

0.4096

1.381

254_K

257_E

0.40803

1.376

58_P

64_A

0.40514

1.366

228_F

232_F

0.40463

1.364

9_A

286_A

0.39282

1.325

9_A

282_V

0.39182

1.321

291_R

315_Y

0.39109

1.319

130_D

135_N

0.38967

1.314

310_S

314_K

0.38737

1.306

38_F

42_A

0.38698

1.305

116_L

212_I

0.38683

1.304

314_K

318_N

0.38669

1.304

170_L

198_A

0.38637

1.303

213_L

217_D

0.38356

1.293

45_C

50_Q

0.38312

1.292

79_I

285_L

0.38251

1.290

4_A

255_W

0.38061

1.283

292_A

315_Y

0.3806

1.283

110_R

144_L

0.37917

1.279

4_A

269_Q

0.37652

1.270

162_S

191_D

0.3764

1.269

112_L

184_I

0.37576

1.267

114_D

118_H

0.37431

1.262

124_V

182_V

0.37248

1.256

159_V

187_S

0.37051

1.249

125_S

180_A

0.3701

1.248

285_L

289_L

0.37008

1.248

72_S

96_P

0.36737

1.239

64_A

83_S

0.36208

1.221

75_N

310_S

0.36169

1.220

280_D

325_T

0.36109

1.218

58_P

78_Q

0.36026

1.215

69_S

73_E

0.35979

1.213

123_R

181_R

0.3594

1.212

130_D

160_I

0.35859

1.209

71_A

78_Q

0.35657

1.202

47_L

76_I

0.35483

1.197

44_I

48_N

0.35481

1.196

170_L

202_L

0.35448

1.195

128_Y

138_A

0.35329

1.191

140_S

143_D

0.35196

1.187

123_R

153_V

0.35176

1.186

125_S

157_S

0.3494

1.178

284_L

330_F

0.3431

1.157

6_V

56_I

0.34269

1.156

126_V

138_A

0.34245

1.155

138_A

142_Q

0.33946

1.145

244_S

249_E

0.33827

1.141

13_I

282_V

0.33815

1.140

124_V

145_L

0.33714

1.137

226_E

229_R

0.33656

1.135

284_L

316_L

0.33277

1.122

283_Y

286_A

0.33102

1.116

61_S

85_S

0.32946

1.111

30_F

42_A

0.32654

1.101

251_F

275_A

0.32519

1.097

5_A

275_A

0.32231

1.087

45_C

49_K

0.32222

1.087

278_A

282_V

0.32093

1.082

43_A

71_A

0.31968

1.078

247_E

322_E

0.31927

1.077

225_N

229_R

0.31739

1.070

48_N

74_W

0.31697

1.069

28_Q

50_Q

0.31606

1.066

172_K

175_E

0.31537

1.063

127_V

169_L

0.31397

1.059

251_F

255_W

0.31386

1.058

80_S

83_S

0.31273

1.055

42_A

45_C

0.31095

1.049

131_D

134_G

0.31063

1.047

198_A

202_L

0.30899

1.042

78_Q

98_F

0.30868

1.041

58_P

71_A

0.3085

1.040

8_L

12_E

0.3082

1.039

6_V

278_A

0.30635

1.033

114_D

144_L

0.30501

1.029

10_I

14_N

0.30452

1.027

144_L

148_R

0.30445

1.027

89_S

100_R

0.30433

1.026

171_K

175_E

0.30337

1.023

135_N

139_D

0.30281

1.021

86_P

106_S

0.30217

1.019

14_N

18_D

0.30183

1.018

9_A

279_Y

0.30104

1.015

80_S

98_F

0.30099

1.015

7_Q

258_S

0.29869

1.007

288_A

292_A

0.29785

1.004

253_K

256_K

0.29669

1.000

38_F

41_Q

0.29427

0.992

172_K

178_S

0.29178

0.984

25_L

286_A

0.29132

0.982

99_F

313_L

0.29114

0.982

137_L

186_C

0.29059

0.980

113_V

145_L

0.2902

0.979

291_R

319_V

0.29012

0.978

268_D

271_P

0.28979

0.977

115_L

119_F

0.28925

0.975

43_A

55_V

0.28866

0.973

115_L

236_L

0.28859

0.973

246_P

250_D

0.28789

0.971

249_E

252_M

0.28691

0.967

199_A

211_W

0.28568

0.963

131_D

161_S

0.28318

0.955

289_L

312_L

0.28282

0.954

125_S

153_V

0.28269

0.953

311_Q

315_Y

0.2819

0.951

42_A

46_S

0.28131

0.949

283_Y

287_H

0.28123

0.948

143_D

146_R

0.28012

0.945

312_L

315_Y

0.27934

0.942

5_A

9_A

0.27891

0.941

187_S

195_F

0.27827

0.938

54_A

77_P

0.27641

0.932

9_A

13_I

0.27631

0.932

223_Q

226_E

0.27615

0.931

7_Q

29_V

0.27482

0.927

321_F

328_V

0.27449

0.926

56_I

79_I

0.2741

0.924

88_L

98_F

0.27268

0.920

267_S

271_P

0.27254

0.919

8_L

255_W

0.27254

0.919

32_T

63_S

0.27149

0.915

173_L

180_A

0.27108

0.914

72_S

95_Y

0.27036

0.912

168_E

171_K

0.26959

0.909

113_V

141_F

0.26935

0.908

163_D

169_L

0.26871

0.906

252_M

256_K

0.26576

0.896

167_E

198_A

0.26519

0.894

12_E

15_N

0.26426

0.891

290_N

293_L

0.26378

0.889

153_V

180_A

0.26374

0.889

170_L

174_K

0.26373

0.889

46_S

52_V

0.26343

0.888

284_L

321_F

0.26323

0.888

109_A

137_L

0.26299

0.887

9_A

283_Y

0.26218

0.884

185_L

195_F

0.26205

0.884

8_L

254_K

0.26172

0.883

99_F

330_F

0.26154

0.882

204_M

209_Y

0.2603

0.878

10_I

25_L

0.26008

0.877

64_A

78_Q

0.25963

0.875

3_L

29_V

0.25958

0.875

135_N

158_V

0.25897

0.873

145_L

152_C

0.2573

0.868

110_R

114_D

0.25603

0.863

86_P

136_S

0.2558

0.863

139_D

142_Q

0.25572

0.862

113_V

148_R

0.25469

0.859

81_P

278_A

0.25452

0.858

141_F

145_L

0.25447

0.858

276_A

324_L

0.25368

0.855

4_A

267_S

0.25219

0.850

124_V

150_G

0.25137

0.848

195_F

199_A

0.25068

0.845

56_I

281_A

0.24965

0.842

127_V

195_F

0.24785

0.836

129_S

134_G

0.24739

0.834

8_L

11_D

0.24679

0.832

232_F

235_V

0.24671

0.832

283_Y

321_F

0.24553

0.828

128_Y

135_N

0.24324

0.820

315_Y

319_V

0.24277

0.819

287_H

321_F

0.24249

0.818

117_K

150_G

0.24215

0.817

52_V

55_V

0.24175

0.815

323_G

326_G

0.24143

0.814

230_E

233_Q

0.24131

0.814

228_F

231_A

0.24095

0.813

40_L

70_L

0.24075

0.812

247_E

250_D

0.24047

0.811

246_P

249_E

0.24031

0.810

60_C

63_S

0.24017

0.810

6_V

27_V

0.23987

0.809

130_D

134_G

0.2393

0.807

39_A

43_A

0.239

0.806

84_T

102_V

0.23868

0.805

166_A

170_L

0.23856

0.804

170_L

199_A

0.23842

0.804

154_A

178_S

0.23832

0.804

80_S

88_L

0.23791

0.802

65_E

88_L

0.237

0.799

114_D

117_K

0.23675

0.798

37_S

41_Q

0.23665

0.798

192_A

217_D

0.23598

0.796

154_A

172_K

0.23536

0.794

97_T

313_L

0.23525

0.793

23_I

26_E

0.23522

0.793

87_S

90_D

0.23378

0.788

30_F

46_S

0.23369

0.788

68_A

98_F

0.23302

0.786

99_F

316_L

0.2328

0.785

200_Y

230_E

0.23277

0.785

102_V

277_Y

0.23269

0.785

77_P

312_L

0.23193

0.782

43_A

47_L

0.23115

0.779

125_S

173_L

0.23113

0.779

224_N

232_F

0.23029

0.777

165_D

168_E

0.22934

0.773

254_K

258_S

0.22917

0.773

125_S

178_S

0.22909

0.773

22_N

26_E

0.22909

0.773

136_S

139_D

0.22906

0.772

64_A

80_S

0.22733

0.767

294_Q

311_Q

0.2269

0.765

160_I

163_D

0.22689

0.765

175_E

178_S

0.22622

0.763

117_K

122_T

0.22588

0.762

96_P

313_L

0.2253

0.760

245_S

248_F

0.22457

0.757

56_I

285_L

0.22423

0.756

183_V

199_A

0.22383

0.755

225_N

228_F

0.22349

0.754

166_A

198_A

0.2231

0.752

101_T

284_L

0.22199

0.749

40_L

43_A

0.22161

0.747

166_A

169_L

0.22159

0.747

229_R

232_F

0.22082

0.745

150_G

153_V

0.2207

0.744

248_F

252_M

0.2201

0.742

83_S

88_L

0.2195

0.740

291_R

318_N

0.21889

0.738

196_L

211_W

0.21768

0.734

44_I

73_E

0.21734

0.733

288_A

316_L

0.21726

0.733

7_Q

27_V

0.21708

0.732

182_V

212_I

0.21669

0.731

128_Y

155_F

0.21602

0.728

174_K

204_M

0.21602

0.728

40_L

44_I

0.21552

0.727

7_Q

10_I

0.2155

0.727

194_Q

198_A

0.21525

0.726

196_L

224_N

0.21523

0.726

53_V

76_I

0.21508

0.725

70_L

74_W

0.21508

0.725

101_T

281_A

0.21476

0.724

271_P

275_A

0.2143

0.723

124_V

141_F

0.214

0.722

67_V

71_A

0.21379

0.721

280_D

324_L

0.21363

0.720

65_E

87_S

0.21357

0.720

36_D

39_A

0.21326

0.719

18_D

23_I

0.21315

0.719

196_L

199_A

0.21308

0.719

41_Q

44_I

0.21258

0.717

79_I

101_T

0.21233

0.716

163_D

166_A

0.21173

0.714

21_P

24_T

0.21122

0.712

196_L

200_Y

0.21091

0.711

44_I

70_L

0.21077

0.711

15_N

18_D

0.21038

0.709

26_E

29_V

0.21006

0.708

29_V

32_T

0.20977

0.707

197_E

201_E

0.20973

0.707

30_F

33_C

0.20847

0.703

256_K

268_D

0.20836

0.703

105_D

108_Q

0.20785

0.701

284_L

319_V

0.20755

0.700

223_Q

227_D

0.20692

0.698

116_L

121_W

0.20683

0.697

317_R

332_S

0.20663

0.697

30_F

50_Q

0.20649

0.696

170_L

204_M

0.20607

0.695

185_L

192_A

0.20434

0.689

26_E

30_F

0.20413

0.688

79_I

281_A

0.204

0.688

16_N

290_N

0.20324

0.685

174_K

202_L

0.20264

0.683

314_K

317_R

0.20249

0.683

90_D

94_R

0.20144

0.679

13_I

17_P

0.20143

0.679

181_R

209_Y

0.20139

0.679

112_L

116_L

0.20125

0.679

138_A

158_V

0.2004

0.676

168_E

172_K

0.1999

0.674

64_A

88_L

0.19976

0.674

316_L

319_V

0.19909

0.671

117_K

145_L

0.19888

0.671

9_A

12_E

0.19879

0.670

182_V

210_V

0.19746

0.666

68_A

95_Y

0.19605

0.661

170_L

173_L

0.19553

0.659

23_I

27_V

0.19506

0.658

224_N

228_F

0.19482

0.657

56_I

81_P

0.19438

0.655

64_A

68_A

0.19434

0.655

66_A

69_S

0.19416

0.655

8_L

258_S

0.19378

0.653

5_A

8_L

0.19376

0.653

27_V

31_D

0.19368

0.653

119_F

182_V

0.19316

0.651

152_C

155_F

0.1931

0.651

32_T

39_A

0.19198

0.647

28_Q

45_C

0.19151

0.646

171_K

202_L

0.1914

0.645

126_V

141_F

0.19061

0.643

84_T

215_D

0.18996

0.641

6_V

10_I

0.18913

0.638

20_L

29_V

0.18783

0.633

153_V

178_S

0.18728

0.632

105_D

136_S

0.1869

0.630

20_L

25_L

0.1866

0.629

209_Y

213_L

0.18541

0.625

258_S

267_S

0.18527

0.625

267_S

270_E

0.18524

0.625

84_T

108_Q

0.18449

0.622

61_S

100_R

0.18423

0.621

23_I

29_V

0.18421

0.621

47_L

70_L

0.18378

0.620

70_L

73_E

0.18246

0.615

57_G

61_S

0.18195

0.614

27_V

30_F

0.18182

0.613

97_T

310_S

0.18092

0.610

247_E

283_Y

0.18061

0.609

141_F

184_I

0.18011

0.607

80_S

101_T

0.17999

0.607

61_S

105_D

0.17936

0.605

46_S

50_Q

0.17926

0.604

40_L

66_A

0.1792

0.604

112_L

212_I

0.17914

0.604

165_D

170_L

0.17824

0.601

167_E

202_L

0.17813

0.601

41_Q

45_C

0.1781

0.601

54_A

312_L

0.17771

0.599

12_E

250_D

0.17761

0.599

14_N

24_T

0.17731

0.598

77_P

97_T

0.17674

0.596

4_A

8_L

0.17603

0.594

130_D

158_V

0.17594

0.593

39_A

46_S

0.17587

0.593

313_L

316_L

0.17479

0.589

194_Q

197_E

0.17474

0.589

105_D

140_S

0.17472

0.589

138_A

155_F

0.17462

0.589

47_L

55_V

0.17394

0.587

43_A

67_V

0.17384

0.586

126_V

152_C

0.17383

0.586

174_K

179_G

0.17351

0.585

47_L

74_W

0.17293

0.583

325_T

328_V

0.17269

0.582

14_N

286_A

0.17187

0.580

78_Q

88_L

0.17177

0.579

96_P

310_S

0.17172

0.579

63_S

67_V

0.17162

0.579

165_D

198_A

0.17004

0.573

113_V

144_L

0.1695

0.572

284_L

287_H

0.16917

0.570

74_W

77_P

0.16909

0.570

183_V

204_M

0.16903

0.570

26_E

31_D

0.16895

0.570

61_S

133_Y

0.16842

0.568

113_V

117_K

0.16791

0.566

61_S

83_S

0.16756

0.565

54_A

79_I

0.16702

0.563

321_F

330_F

0.16662

0.562

20_L

24_T

0.16652

0.562

13_I

25_L

0.16634

0.561

257_E

268_D

0.16628

0.561

171_K

174_K

0.16624

0.561

159_V

191_D

0.1659

0.559

128_Y

134_G

0.16579

0.559

276_A

280_D

0.16563

0.559

169_L

195_F

0.1656

0.558

292_A

311_Q

0.16551

0.558

65_E

132_D

0.16548

0.558

277_Y

325_T

0.16529

0.557

126_V

142_Q

0.16522

0.557

83_S

100_R

0.16522

0.557

64_A

98_F

0.16481

0.556

44_I

74_W

0.16454

0.555

43_A

74_W

0.16439

0.554

245_S

249_E

0.16424

0.554

21_P

25_L

0.16416

0.554

105_D

133_Y

0.16416

0.554

35_D

39_A

0.16382

0.552

137_L

214_T

0.1637

0.552

118_H

148_R

0.1634

0.551

46_S

49_K

0.16305

0.550

224_N

230_E

0.16302

0.550

133_Y

137_L

0.16288

0.549

Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.

HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits: Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)