A Chronic Obstructive Pulmonary Disease (COPD) exacerbation was defined as worsening in COPD symptoms requiring treatment with either a course of systemic steroid or hospitalisation. The percentage of participants who had experienced COPD exacerbation at the end of the study for each treatment group.

A Chronic Obstructive Pulmonary Disease (COPD) exacerbation was defined as worsening in COPD symptoms requiring treatment with either a course of systemic steroid or hospitalisation. Number of COPD exacerbation during 12-week randomization treatment

The Total COPD Symptom score is the sum of the measures night-time awakening, breathlessness and cough, ranges from 0 to 12 with 12 being the most severe. The change from Run-in period average to Treatment period average for each treatment group.

Use of Rescue Medication [ Time Frame: Daily during run-in period and daily during 12-week randomization treatment ] [ Designated as safety issue: No ]

The change from Run-in period average to Treatment period average for each treatment group.

Documented Chronic Obstructive Pulmonary Disease symptoms for more than 2 years

A smoking history of at least 10 pack years

Exclusion Criteria:

History and/or current clinical diagnosis of asthma

History and/or current clinical diagnosis of atopic diseases such as allergic rhinitis

Contacts and Locations

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study.
To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below.
For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01069289