Convert the element that you want the hover interaction to occur into a Custom Component. In the Pages/States panel, rename the state to 'normal', then use the Duplicate State button. Relabel this state to 'over'. Now select the asset that needs to become the colored version. You can either delete the item from the art board, and place the colored version from the library panel, or you can use the properties panel to swap the elements.

Return to the top level of the project, then with this new component selected, use the interactions panel to add the "On RollOver" interaction, you can then transition to a new state where the color version of the item is shown. You can add some nice transitions as well.

In the meantime tried something else; made two layers for a object, a black and white one and a colored one. Than made a button out of the object, and on the over-button-state I disabled the view in the layerspanel (turned off the eye icon)

I had to set the smooth transition, in order to turn off the stobe-like effect when rolling over.

But I don't know if this is the proper way to do it.

So I would like to try the Custom Component option, but with the item going back to normal after rollover.