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The Amulet of Yendor is the most powerful known artifact of unknown origin. It is said that the amulet is able to fulfil[sic] any wish if its owner's will-power is strong enough to "persuade" it to do it.

The Amulet of Yendor first appeared in Rogue, the game which spawned the genre of roguelike games, which Pixel Dungeon belongs to. It also appears in NetHack, Brogue (which was the main inspiration for Pixel Dungeon), and many other roguelikes.

As seen from the game description & besides the Dwarves, Pixel Dungeon revolves around this ultimate artifact.

If you have the Amulet of Yendor in your backpack & you get revived by an Ankh, the Amulet of Yendor will be in your Backpack upon revival.

The screen showed once the dungeon has been left shows your character class standing beside a marsupial rat, possibly showing you used the Amulet of Yendor to become friends with the creatures in the Dungeon.