The role of Peripheral Nuclear Pore Complex (NPC) structures in nuclear transport and NPC architecture

Abstract

The role of peripheral Nuclear Pore Complex (NPC) structures in nuclear transport and NPC architecture. Dissertation der Fakultät für Biologie der Ludwig-Maximilians-Universität München eingereicht am 29. Mai 2002 von Tobias Christian Walther aus München Prüfungskommission: Prof. Dr. R. Kahmann (Gutachter) Prof. Dr. Th. Cremer (Gutachter), vertreten durch Prof. Dr. W. Bandlow Prof. Dr. Ch. David Prof. Dr. D. Eick (Protokoll) Tag des Rigorosums: 21. August 2002 The studies for this PhD thesis were performed in the time from October 1999 to May 2002 in the laboratory of Dr. Iain W. Mattaj at the European Molecular Biology Laboratory (EMBL) in Heidelberg. 1 Erklärung Ich versichere, dass ich meine Dissertation mit dem Titel "The role of peripheral Nuclear Pore Complex (NPC) structures in nuclear transport and NPC architecture.", selbständig, ohne unerlaubte Hilfe angefertigt und mich dabei keiner anderen als der von mir ausdrücklich bezeichneten Quellen und Hilfen bedient habe. Die Dissertation wurde in der jetzigen oder einer ähnlichen Form noch bei keiner anderen Hochschule eingereicht und hat noch keinen sonstigen Prüfungszwecken gedient. _____________________________ ______________________________ (Ort, Datum) (Tobias Walther) 2 "I heard someone who had a book of Anaxagoras, as he said, out of which he read that mind was the disposer and cause of all, and I was quite delighted at the notion of this, which appeared admirable, and I said to myself: If mind is the disposer, mind will dispose all for the best, and put each particular in the best place; and I argued that if anyone desired to find out the cause of the generation or destruction or existence of anything, he must find out what state of being or suffering or doing was best for that thing, and therefore a man had only to consider the best for himself and others, and then he would also know the worse, for that the same science comprised both.(...) What hopes I had formed, and how grievously was I

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