Gamma-aminobutyric acid [GABA] is a major inhibitory neurotransmitter in the central nervous system. [It is responsible for controlling the delicate balance between physiological acceleration and “braking” (inhibition), as needed.]

GABA metabolism is dependent on the activity of three enzymes: glutamic acid decarboxylase, GABA-transaminase and succinic semialdehyde dehydrogenase.

Decreased activity of these enzymes may cause many neurological syndromes, such as stiff-person syndrome, chronic fatigue syndrome, anxiety disorders and seizures.

This article is a review of most important problems related to an impairment of GABA metabolism.