Mississippi River Cruises

Queen of the Mississippi

Cruise the Mississippi River Aboard Three New Paddlewheelers

Mississippi River cruises with American Cruise Lines are an exceptional way to discover American history and culture as you travel the Mississippi, Ohio and Cumberland Rivers. Enjoy luxurious accommodations and finely-tailored, personal service aboard three new paddlewheeler river boats built specifically for Mississippi River cruising. Cruise from New Orleans, Memphis, Nashville, and St. Paul and more with a variety of one, two and three week itineraries.

Cruise the lower Mississippi River with this Lower Mississippi River cruise as we explore the culture, music, history and cuisine of the South.

Your 8-day journey begins in either New Orleans or Memphis with stops in Oak Alley, Baton Rouge, St. Francisville, Natchez, and Vicksburg. Enjoy guided shore excursions at each port including a tour of the National Historic Landmark Oak Alley Plantation, the Louisiana State Capital in Baton Rouge and National Military Park in Vicksburg.

Cruise the land bayous and Southern Belles on an 8-day, round-trip cruise from New Orleans, LA. Explore New Orleans, Oak Alley, Natchez, Vicksburg, St. Francisville, Baton Rouge and Houmas House as you travel in relaxed comfort with American Cruise Lines.

Cruising the upper Mississippi River from St. Louis to St. Paul is filled with changing landscapes and cultural influences.

From tranquil towns and bustling cities to impressive locks and dams, adventure is around every corner. Visit St. Louis, Alton, Hannibal, Burlington, Davenport, Dubuque, La Crosse, Winona, Red Wing, and St. Paul.

Ohio River Cruise

St. Louis, MO to Cincinnati, OH

Cruise the Mississippi and Ohio Rivers from St Louis to Cincinnati, OH aboard the Queen of the Mississippi. Beneath this incredible paddlewheeler’s gleaming brass is a framework of modern technology that provides spacious accommodations and the most comfortable cruising experience imaginable.

Join us as we explore the historic ports of St. Louis, Paducah, Cave in Rock, Henderson, Mt. Vernon, Louisville, Madison, and Cincinnati.