A top Manhattan plastic surgeon thinks so, after comparing some shots from Thursday night’s debate with earlier photos of the Delaware senator.

“Yes, absolutely, and I would bet my next paycheck on this assessment,” said Dr. Oleh Slupchynskyj, of the Aesthetic Institute.

After being shown the shots by The Post, the doctor concluded that most of the work was around Biden’s eyes.

“It appears that he had some sort ‘Lateral Brow/Eyelid Lift,’ ” he told The Post.

“Whether it be a string lift or a formal surgical lift, [it’s] hard to say. But I would bet on some kind of lateral brow lift with strings or non-invasive technique.”

Dr. Slupchynskyj also said that he thought that Biden had come to the debate prepared with some Botox injections.

“He definitely had Botox in the forehead region,” the doctor concluded from the photos.

Biden’s representatives scoffed at the idea the senator had gone under the knife. They insisted that he has never had any work done.

“I don’t know how to say no firmly enough. Absolutely not. That’s not a misdiagnosis, that’s called malpractice,” said his spokesman, David Wade.

“Completely untrue, completely unsubstantiated, completely stupid, and I’d remind Dr. Slupchynskyj that the last doctor who made a diagnosis based on something he saw on television was Bill Frist and it cost him his credibility,” Wade said, referring to the infamous 2005 diagnosis of brain damage patient Terri Schiavo by the then Senate majority leader from the floor of the Senate.

Botox is the commercial name for the botulinum toxin. Popular among Hollywood celebrities, it can be injected into the face to get rid of laugh lines, crows feet and creases, according to the American Society of Plastic Surgeons.

Paul Thompson, the director of education at the Make-up Designory school in Manhattan, said he and instructors who were shown the same “before-and-after” photos of Biden “all agree that the make-up job done on Biden was good.”