The firm published critical journals such as Lovecraft Studies (now superseded by Lovecraft Annual published by Hippocampus Press) and Studies in Weird Fiction, both edited by Joshi; Crypt of Cthulhu, edited by Robert M. Price; and has also published critical studies of Campbell (The Count of Thirty, edited by Joshi) and Fritz Leiber (Witches of the Mind, written by Bruce Byfield).

Necronomicon Press was awarded the World Fantasy Award in 1994 and 1996 for its contributions to small-press publishing, and the British Fantasy Award in 1995 for its publication Necrofile: The Review of Horror Fiction.

Necronomicon Press' books are mostly illustrated by Jason Eckhardt and Robert H. Knox. Some of their titles, such as Lovecraft's The Colour Out of Space, contain original artwork from the amateur writers' magazines of Lovecraft's own time. One issue of Lovecraft Studies was illustrated by Sam Gafford, who is currently an illustrator in the comic book industry.

A flood in March 2010 caused a loss of more than $20,000 worth of books.