Still, she said, she's never loved her "bubble butt." But she's now OK with her body overall.

"Now people are paying money to get things injected. Like we're sitting here dying over squats and I'm like, 'Wait, what's the trend?!'"

Aniston was previously tapped as most beautiful woman by People in 2004, when she was married to Brad Pitt and wrapping up a decade of "Friends." Now she's married to Justin Theroux and has a big-screen ensemble comedy, "Mother's Day," set to open at the end of the month.

No, she shouldn't be defined by who she's married to, but the gossip surrounding Aniston's love life has been significant enough over the years that it's at least worth a mention. Given her experience in the spotlight, she's decided against indulging in social media.

"You know they say once you've been burned? I don't feel the need to go seek out people hurting my feelings," she told People, laughing. "Because you know if you're going to go find something positive, you're bound to bump into something that's not so positive. And I'm not against social media, honestly, it's just not my thing."