401

Food

401 a.k.a. Vitamin C or L-ascorbic acid, or simply ascorbate, is an essential nutrient for humans and certain other animal species. Vitamin C refers to a number of vitamers that have vitamin C activity in animals, including ascorbic acid and its salts, and some oxidized forms of the molecule like dehydroascorbic acid. Ascorbate and ascorbic acid are both naturally present in the body when either of these is introduced into cells, since the forms interconvert according to pH.

Music

Places

401 a.k.a. Ontario Highway 401: King's Highway 401, also known by its official name as the Macdonald–Cartier Freeway and colloquially as the four-oh-one, is a 400-series highway in the Canadian province of Ontario. It stretches 817.9 kilometres from Windsor to the Quebec border. The part of Highway 401 that passes through Toronto is the busiest highway in the world, and one of the widest. Together with Quebec Autoroute 20, it forms the road transportation backbone of the Quebec City–Windsor Corridor, along which over half of Canada's population resides. The entire route is maintained by the Ministry of Transportation of Ontario and patrolled by the Ontario Provincial Police. The posted speed limit is 100 km/h throughout its length.

Miscellanea

401 a.k.a. Cycloserine is a drug sold under the brand name Seromycin. It is an antibiotic effective against Mycobacterium tuberculosis. Since the discovery that cycloserine is able to penetrate into the central nervous system, numerous studies have been conducted to assess the efficacy of cycloserine for psychiatric disorders. It has been found to be effective in the treatment of some neurological disorders, due to its effect as a selective partial agonist of the N-methyl-D-aspartic acid glutamatergic receptors found in the basolateral nucleus of the amygdala. Specifically, cycloserine affects the glycine-binding sites which are important for opening these NMDA channels. Cycloserine is stable under basic conditions, with the greatest stability at pH = 11.5. Under mildly acidic conditions, it breaks down into hydroxylamine and D-serine, whereas under prolonged hydrolysis, it breaks down into hydroxylamine and DL-serine.

401 a.k.a. Essential hypertension is the form of hypertension that by definition, has no identifiable cause. It is the most common type of hypertension, affecting 95% of hypertensive patients, it tends to be familial and is likely to be the consequence of an interaction between environmental and genetic factors. Prevalence of essential hypertension increases with age, and individuals with relatively high blood pressure at younger ages are at increased risk for the subsequent development of hypertension. Hypertension can increase the risk of cerebral, cardiac, and renal events.