Handler on the other hand, has been very vocal about not having, nor ever wanting to have children.

In their chat, the talk show host brought up how having no kids meant she still felt quite young.

"I have [car insurance, a mortgage] but I still feel like a little girl,” she told Witherspoon.

"I don't feel like that, because I have a little girl and I have two little boys. I feel like the grown up,” Witherspoon said.

Chelsea Handler.Richard Shotwell

When Handler asked the Walk The Line actress if she "ever felt irresponsible”, Witherspoon said that being a mum is an exhausting job.

"I think every mum feels like 'If one day I ran away someone maybe would take them, because they're adorable right'. There's times I wish I could run off but I just enjoy it so much and I love being their mum and I'm really lucky to be their mum,” she said.

But when Handler asked Witherspoon if that meant the comedian was somehow missing out, the Big Little Lies actress had an empowering message for her.

"No. I really respect and admire when women decide not to have kids, or men, because it is such a huge responsibility and if you in any way feel like, 'Oh, I'm not sure', then don't do it,” she said.

Reese Witherspoon.Dennis Van Tine/STAR MAX/IPx

Adding, "It's too hard and I really respect people who are vocal about it too because that's okay too. Every life choice is alright and I think it normalises it when we talk about it.”

"I can't stand that. When we judge people for the life choices they make and it's like, 'can we just be over that, it's 2017'. I'm so sick of that,” she ended.

And clearly the audience were happy with Witherspoon's supportive message, erupting into applause.