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Gear Second is the most powerful of the two we have seen so far, but the Gear Third for some reason has the worse side effects. If Gear Fourth is in fact an ability that increases speed, but sacrifices strength, then it's side effects might be similar to it's Gear Third counterpart. Though a shrunken state is unlikely after using Gear Fourth, I still believe the negative side effects of Gear Third would be similar. In some way Luffy's body would be changed and he would be left pretty much defenseless in front of a opponent if his Gear Fourth fails.

Isnt Gear 3 is the strongest in terms of physical strength but he sacrifices a lot of speed for it. As for Gear 4 i think it would be boring if he combined gears 2 &3

Isnt Gear 3 is the strongest in terms of physical strength but he sacrifices a lot of speed for it. As for Gear 4 i think it would be boring if he combined gears 2 &3

Correct me if im wrong, but has anyone seen Luffy using Gear First? I think the next gear will be gear first and the most powerful gear he will be using. I might be wrong about the gear first thing, i had to skip couple of episodes/chapters for a reason, dont ask. but thats what i think anyways.

The result is a giant Luffy with above average movement rate. That is gear 4th. The side effect is that Luffy loses his stretchability after deactivation for several days, due to the abnormal isocaloric process that hardens Luffy. More over, instead of Chibi Luffy, Luffy will slowly shrink from giant form till normal. Isoprene is also considered a a human carcinogen. Thereby Luffy will be more likely to have cancer in the future.

Mugiwara Pirates on drugs, awesome. To me that's kind of lame, taking steroids is Chopper's thing. Luffy consuming something like that to make him stronger doesn't seem likely to me, unless of course he ate it by accident.

Knowing Oda there is no way we will be able to guess Luffy's next technique :p .

But just to add to the fun, what if Chopper develops a potion or something along those lines that will allow Luffy to eat a 2nd Devil Fruit?

Yeah Oda is very good at surprising us.

I can see that as a possibility.. but does Chopper have that kind of skill? I can see Vegapunk coming up with something like that in the future, but I don't think Luffy would ever get a second DF ability.