Tylenol Sinus (Acetaminophen / Phenylephrine) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have a stuffy nose, a headache, and pain.

The decongestant (phenylephrine) has fewer side effects than other decongestants like pseudoephedrine. It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.

The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than to other pain medications like aspirin or ibuprofen.

Downsides

If you don't need both of the medications in this combination, you'd be taking extra medicine and can have extra side effects for no reason.

The pain reliever (ibuprofen) can interact with other medications and make health problems like stomach bleeding and ulcers worse.

It's not safe to take ibuprofen if you're pregnant since it increases the risk of heart defects in babies.

Pseudoephedrine, the decongestant in Advil Cold And Sinus (Ibuprofen / Pseudoephedrine), can make your heart race or make you feel anxious and restless.

If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.

Phenylephrine doesn't last as long as other decongestants like pseudoephedrine.

You shouldn't use it if you have high blood pressure.

To avoid hurting your liver, you need to keep track of the total amount of acetaminophen (APAP) you are taking since it is a very common ingredient in pain and cold/flu combination medicines.