Pelger-Huet anomaly is a congenitally acquired condition of nuclear segmentation that has no clinical significance. There is no loss of cellular function.

The condition can be suspected if typical bilobed, "pince-nez" nuclei are observed (see top image on the right). Band neutrophils usually have two distinct lobes, connected by a relatively short but thick bridge. Monolobulated cells may also be encountered, especially if a homozygous inheritance is present, as illustrated in the bottom image on the right. If 70% or more of the segmented neutrophils on the differential possess these nuclear morphologies, the possibility of a homozygous Pelger-Huet should be considered.