The hysterical tale of a "Spot", a talking canine whose ultimate wish is to become a "real boy". When the opportunity presents itself - through the DNA manipulations of whacko scientist Ivan Krank (voiced by Kelsey Grammer) - Spot quickly follows his "family" (his best friend and master, Leonard, and their mother/fourth grade teacher, Mrs. Helperman) to Florida in order to make the evolution to human form. However, Dr. Krank's experiments have been far from perfect thus far (witness the mosquito girl and alligator boy) and, although Spot's transformation to humanity is complete, nobody calculated "dog years" into the equation. Spot transforms to a middle age man! Hijinks ensue as Spot's pals attempt to right the genetic wrong and bring some level of normalcy to their already off-kilter lives.