Patients will have an endometrial injury done on purpose, between 18-24 days prior to IVF cycle with a transfer catheter on the surgery outpatient department.

Endometrial Injury

Done between 18-24 days prior to embryo transfer cycle.

Using transfer catheter.

Introduction of the same to the uterine fundus.

Systematic scrapping of the four uterine walls, lengthwise.

Performed by a skilled doctor.

Subsequent ultrasound control

Procedure: scratching

Endometrial Injury

Done between 18-24 days prior to embryo transfer cycle.

Using transfer catheter.

Introduction of the same to the uterine fundus.

Systematic scrapping of the four uterine walls, lengthwise.

Performed by a skilled doctor.

Subsequent ultrasound control.

Other Name: endometrial enjury

Placebo Comparator: scratching simulation

Patients will come to control visit between day 18-24. A scratching simulation will be done.

Detailed Description:

This is a randomized, comparative, prospective, double Blind study.

The First stage of this study consists of revising the patients medical records to identify possible candidates. Patients indicated are randomized into two groups: experimental and control. They are followed up to 12 week of pregnancy.

known positivity for human immunodeficiency virus (HIV), hepatitis C or B virus (HCV / HBV) of the candidate or her partner.

Uterine Factor(submucosal fibroids, intramural fibroids> 4 cm)

Hydrosalpinx

Patients receiving immune treatment

Positive Diagnosis Thrombophilia

preimplantation genetic diagnosis needed

In case of using marital sperm are excluded the following patients:Altered male karyotype, Altered Meiosis in testicular biopsy, Altered FISH, sperm Fragmentation> 45%

Pregnancy contraindication

Known allergy to preparations containing estrogens or any of its excipients.

Simultaneous participation in another clinical trial with medication.

Do not want or can not adjust to study protocol.

Contacts and Locations

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study.
To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below.
For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01842178