URMC Research Network

Cytochrome P-450 Enzyme System

"Cytochrome P-450 Enzyme System" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.

A superfamily of hundreds of closely related HEMEPROTEINS found throughout the phylogenetic spectrum, from animals, plants, fungi, to bacteria. They include numerous complex monooxygenases (MIXED FUNCTION OXYGENASES). In animals, these P-450 enzymes serve two major functions: (1) biosynthesis of steroids, fatty acids, and bile acids; (2) metabolism of endogenous and a wide variety of exogenous substrates, such as toxins and drugs (BIOTRANSFORMATION). They are classified, according to their sequence similarities rather than functions, into CYP gene families (>40% homology) and subfamilies (>59% homology). For example, enzymes from the CYP1, CYP2, and CYP3 gene families are responsible for most drug metabolism.

This graph shows the total number of publications written about "Cytochrome P-450 Enzyme System" by people in the URMC Research Network by year, and whether "Cytochrome P-450 Enzyme System" was a major or minor topic of these publication.

Below are the most recent publications written about "Cytochrome P-450 Enzyme System" by people in Profiles.