The people of Antique are predominantly Christians, predominantly Roman Catholic. Even today, the Catholic Church remains influential in both the society and politics of the province. Other religious denominations present in the province include Protestants and Nontrinitarian, Iglesia Filipina Independiente more commonly known as Aglipayan Church, Baptist Churches, Iglesia ni Cristo, Seventh-day Adventist Church, Jehovah's Witnesses, and Church of Latter Day Saints, among others.

In the mountains, remnants of ancient folk beliefs persist. Babaylans or native priestesses continue to divine the future, heal the sick or conjure spells.