Only Sanchez remains in the starting line-up for United from their win over Yeovil. David de Gea replaces Sergio Romero in goal, while Antonio Valencia, Chris Smalling, Phil Jones and Ashley Young start in the back four. Paul Pogba and Nemanja Matic sit in front of the defence, while Sanchez combines in a three-man supporting line with Lingard and Anthony Martial behind Lukaku.

Spurs have made six changes from their draw with Newport County at the weekend. Hugo Lloris returns between the sticks, while Davinson Sanchez and Ben Davies come into the back four. Son Heung-Min, Christian Eriksen and Dele Alli also return to the starting line-up behind Harry Kane, who spearheads the attack.