Enhanced estrogenic effects of biotransformed soy extracts

This study aimed to improve the process conditions for biotransformation of soymilk polyphenols by tannase to obtain higher amounts of isoflavone aglycones and metabolites such as equol. The estrogenic potential of the extracts was evaluated in in vitro assays. The results showed that the aglycones increased 36–46 times after reaction with tannase and proved that it is possible to produce equol in soymilk using an enzymatic bioprocess, without gut microbial intervention. Moreover, the soymilk biotransformed by tannase presented higher estrogenic action in the MCF-7 BUS cell line assay, making it a promising nutraceutical with possible effects in the attenuation or treatment of menopause symptoms.Graphical abstract

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is a major component of health and well-being, although it is often neglected by both patients and health care providers. Sexual dysfunction appears early after menopause due to both vaginal dryness/dyspareunia and decreased libido, as an effect of hypoestrogenism in the periphery as well as in the central nervous system. Systemic (hormone replacement therapy) and topical estrogens (in the form of vaginal creams/gels) represent the main available therapeutic interventions.

Objectives: Women experience varying physical and psychological symptoms as they transit through post-reproducitve phase of life or Menopause. The commonly recommended Hormone Replacement Therapy (HRT)2 is losing its popularity among midlife women due to associated risks and side-effects. Hence the objective of this study was to develop and investigate the effect of a Complementary Alternative Medicine (CAM)3, which was holistic in nature.

Abstract
Nicotiana glauca is a cosmopolitan shrub, used in medicine to treat swellings, wounds, sores and cancer. However, its users lack of knowledge of the adverse effects. We seek to evaluate the effects of lipid extracts from N. glauca on myoblasts, identifying the compounds which cause undesirable effects. Myoblasts are important in muscle homeostasis, thus a high death rate of them cause myopathies. We performed an ethanolic extraction from leaves of N. glauca and the extract was successively partitioned with hexane, chloroform and ethyl acetate. The effects of extracts in C2C12 cells were analysed by termin...

This study also found that Proteus DNA, a genus with many uropathogenic species (Drzewiecka, 2016), was more prevalent in women with OAB compared to asymptomatic controls (Curtiss et al., 2017).
IC
A recent study by Abernethy et al. suggested that the microbiome may play a role in IC (Abernethy et al., 2017). In this study, 16S rRNA analysis determined the microbiome of catheterized urine from women (n = 40) with IC was not dominated by a single genus and was less likely to contain Lactobacillus compared to asymptomatic women. Abernethy et al. also showed that L. acidophilus was associated with less severe scores on the ...

Maunil K. Desai1 and Roberta Diaz Brinton2,3*
1School of Pharmacy, University of Southern California, Los Angeles, CA, United States
2Center for Innovation in Brain Science, University of Arizona, Tucson, AZ, United States
3Departments of Pharmacology and Neurology, College of Medicine, University of Arizona, Tucson, AZ, United States
Women have a higher incidence and prevalence of autoimmune diseases than men, and 85% or more patients of multiple autoimmune diseases are female. Women undergo sweeping endocrinological changes at least twice during their lifetime, puberty and menopause, with many women undergoin...

It turns out that numbers don ’t necessarily tell the whole story•Fitness tips: what you need to know about perimenopause“Are you sure you want to do a home hormone test?” my editor asked. “Are you sure it’s not too personal?” Why would that be personal, I think. This is stuff I make without trying. It’s not even as revealing as keeping a food diary. Then two tests arrived from medical test-by-post company Thriva; one female baseline hormone test and one menopause test, so I realised that actually, yeah, that is pretty personal.There are a couple of reasons why someone might w...

Conclusions
World population is aging and the increase in life expectancy is often unhealthy. In particular, musculoskeletal aging, which leads to sarcopenia and osteoporosis, has several causes such as changes in body composition, inflammation, and hormonal imbalance. Sarcopenia, osteoporosis, and more frequently, sarcopenic obesity are commonly associated with aging and frequently closely linked each other, often leading to the development of a frailty syndrome. Frailty syndrome favors an increased risk of loss function in daily activities, for cardiovascular diseases, cancers, falls, and mortality. As the number of eld...