Rheumatoid arthritis (RA) is a chronic autoimmune disease which causes inflammation and deformity of the joints . It affects over seven million individuals in the 10MM covered in this report (US, France, Germany, Italy, Spain, UK, Japan, Australia, China, and India) and the prevalence is expected to grow to just over 8.5 million individuals by 2023. The anti-TNFs have been effective in treating the signs and symptoms of RA and inhibiting progression to erosive bone disease. However, the landscape is quickly changing with the introduction of biosimilars, novel biologics, and a class of oral therapies known as JAK inhibitors, all of which will change the market dynamics between 2013 and 2023. With the anti-TNFs as extremely effective therapies for RA, the market is extremely competitive for new entrants and will undergo further pressure as biosimilars are approved and launch.

Actemra (tocilizumab) is a first-in-class, recombinant, humanized, IgG1 mAb against the interleukin-6 receptor (IL-6R), and is indicated for the treatment of RA patients with moderate to severe, active disease. It was developed by Genentech (now a wholly-owned subsidiary of Roche). Tocilizumab is marketed under the brand name Actemra in the US, and as RoActemra in the 5EU by Roche. Chugai has the development and marketing rights to the product in Japan.

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