Tau detection

The human tau antibody products are affinity-purified IgG antibodies that recognize human tau protein isoforms. The anti-human tau antibodies are raised in mouse or rabbit using synthetic peptides or brain tissue isolates and are applicable for Western blot (WB) or immunohistochemistry (IHC) detection of human tau protein isoforms.

The Human Tau Antibody products are affinity-purified IgG antibodies that recognize human tau protein isoforms. The anti-human tau antibodies are raised in mouse or rabbit using synthetic peptides or brain tissue isolates and are applicable for Western blot (WB) or immunohistochemistry (IHC) detection of human tau protein isoforms.

The human microtubule-associated protein tau (MAPT) gene transcript undergoes a complex series of alternative splicing events that result in several differentially expressed mRNA species. The protein isoforms translated from these mRNAs are distinguished by the number of binding domains located at their carboxy termini and can range in length from 352 to 441 amino acids.

Tau proteins promote the assembly and stability of microtubules in neuronal cells, and primarily in the distal portions of axons. Mutations in the MAPT gene are associated with a range of neurodegenerative diseases, including Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. Hyperphosphorylation of tau proteins leads to the assembly of tangled filaments that are implicated in the pathogenesis of Alzheimer's disease.

Tau protein is a microtubule-associated protein expressed in neuroaxons which has molecular weight of 50-70 kDa. Some Alzheimer's patients have sites where tau protein is accumulated abnormally. This antibody reacts with the phosphorylated part of the Tau protein, at amino acid sites, 386-406 (TDHGAEIVYKSPVVSGDTSPR). It does not react with the most carboxyl-terminal peptide (396-441) of the normal human Tau protein.

Notice to purchaser

Our products are to be used for Research Use Only. They may not be used for any other purpose, including, but not limited to, use in humans, therapeutic or diagnostic use, or commercial use of any kind. Our products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products or to provide a service to third parties without our prior written approval.

Tau protein is a microtubule-associated protein expressed in neuroaxons which has molecular weight of 50–70 kDa. Some Alzheimer's patients have sites where tau protein is accumulated abnormally. This antibody reacts with the phosphorylated part of the Tau protein, at amino acid sites, 386–406 (TDHGAEIVYKSPVVSGDTSPR). It does not react with the most carboxyl-terminal peptide (396–441) of the normal human Tau protein.

Notice to purchaser

Our products are to be used for Research Use Only. They may not be used for any other purpose, including, but not limited to, use in humans, therapeutic or diagnostic use, or commercial use of any kind. Our products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products or to provide a service to third parties without our prior written approval.

Tau protein is a microtubule-associated protein expressed in neuroaxons which has a molecular weight of 50–70 kDa. Some Alzheimer's patients have sites where tau protein is accumulated abnormally. It is known that six isoforms of tau protein are formed by alternative splicing of the tau gene, located on chromosome 17. This monoclonal antibody can specifically recognize the junction between exons 1 and 4 of both Tau 352 and Tau 383, and it is useful for brain research.

Notice to purchaser

Our products are to be used for Research Use Only. They may not be used for any other purpose, including, but not limited to, use in humans, therapeutic or diagnostic use, or commercial use of any kind. Our products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products or to provide a service to third parties without our prior written approval.

Cross-section of human brain tissue from a patient with Alzheimer's disease after IHC staining with Anti-Human Tau Rabbit IgG Antibody

Cross-section of human brain tissue from a patient with Alzheimer's disease after IHC staining with Anti-Human Tau Rabbit IgG Antibody.

10233B

Anti-Human Tau/Amino Junction (9A1) Mouse IgG MoAb

100 ug

$545.00

Tau protein is a microtubule-associated protein expressed in neuroaxon and has molecular weight of 50–70 kDa. Some Alzheimer's patients have sites where tau protein is accumulated abnormally. It is known that six isoforms of tau protein formed by alternative splicing of tau gene located on chromosome 17. This monoclonal antibody can specifically recognize junction between exon 1 and 4 of both Tau 352 and Tau 383, and it is useful for the study of brain research.

Notice to purchaser

Our products are to be used for Research Use Only. They may not be used for any other purpose, including, but not limited to, use in humans, therapeutic or diagnostic use, or commercial use of any kind. Our products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products or to provide a service to third parties without our prior written approval.

Tau protein is a microtubule-associated protein expressed in neuroaxon and has molecular weight of 50–70 kDa. Some Alzheimer's patients have sites where tau protein is accumulated abnormally. It is known that six isoforms of tau protein formed by alternative splicing of tau gene located on chromosome 17. This monoclonal antibody can specifically recognize junction between exon 1 and 4 of both Tau 352 and Tau 383, and it is useful for the study of brain research.

Notice to purchaser

Our products are to be used for Research Use Only. They may not be used for any other purpose, including, but not limited to, use in humans, therapeutic or diagnostic use, or commercial use of any kind. Our products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products or to provide a service to third parties without our prior written approval.

Tau protein is a microtubule-associated protein expressed in neuroaxon and has molecular weight of 50–70 kDa. Some Alzheimer's patients have sites where tau protein is accumulated abnormally. It is known that six isoforms of tau protein formed by alternative splicing of tau gene located on chromosome 17. This monoclonal antibody can specifically recognize junction between exon 1 and 4 of both Tau 352 and Tau 383, and it is useful for the study of brain research.

Notice to purchaser

Our products are to be used for Research Use Only. They may not be used for any other purpose, including, but not limited to, use in humans, therapeutic or diagnostic use, or commercial use of any kind. Our products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products or to provide a service to third parties without our prior written approval.

Tau protein is a microtubule-associated protein expressed in neuroaxon and has molecular weight of 50–70 kDa. Some Alzheimer's patients have sites where tau protein is accumulated abnormally. It is known that six isoforms of tau protein formed by alternative splicing of tau gene located on chromosome 17. This monoclonal antibody can specifically recognize junction between exon 1 and 4 of both Tau 352 and Tau 383, and it is useful for the study of brain research.

Notice to purchaser

Our products are to be used for Research Use Only. They may not be used for any other purpose, including, but not limited to, use in humans, therapeutic or diagnostic use, or commercial use of any kind. Our products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products or to provide a service to third parties without our prior written approval.

Tau protein is a microtubule-associated protein expressed in neuroaxon and has molecular weight of 50-70 kDa. Some Alzheimer's patients have sites where tau protein is accumulated abnormally. It is known that six isoforms of tau protein formed by alternative splicing of tau gene located on chromosome 17. This monoclonal antibody can specifically recognize junction between exon 1 and 4 of both Tau 352 and Tau 383, and it is useful for the study of brain research.

Notice to purchaser

Our products are to be used for Research Use Only. They may not be used for any other purpose, including, but not limited to, use in humans, therapeutic or diagnostic use, or commercial use of any kind. Our products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products or to provide a service to third parties without our prior written approval.

Tau protein is a microtubule-associated protein expressed in neuroaxon and has molecular weight of 50–70 kDa. Some Alzheimer's patients have sites where tau protein is accumulated abnormally. It is known that six isoforms of tau protein formed by alternative splicing of tau gene located on chromosome 17. This monoclonal antibody can specifically recognize junction between exon 1 and 4 of both Tau 352 and Tau 383, and it is useful for the study of brain research.

Notice to purchaser

Our products are to be used for Research Use Only. They may not be used for any other purpose, including, but not limited to, use in humans, therapeutic or diagnostic use, or commercial use of any kind. Our products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products or to provide a service to third parties without our prior written approval.

Additional product information

Please see the product's Certificate of Analysis for information about storage conditions, product components, and technical specifications. Please see the Kit Components List to determine kit components. Certificates of Analysis and Kit Components Lists are located under the Documents tab.

Takara Bio USA, Inc. (TBUSA, formerly known as Clontech Laboratories, Inc.) provides kits, reagents, instruments, and services that help researchers explore questions about gene discovery, regulation, and function. As a member of the Takara Bio Group, TBUSA is part of a company that holds a leadership position in the global market and is committed to improving the human condition through biotechnology. Our mission is to develop high-quality innovative tools and services to accelerate discovery.

FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES (EXCEPT AS SPECIFICALLY NOTED).

Capturem Trypsin provides rapid, efficient, and complete digestion of protein samples, allowing an uninterrupted mass spectometry workflow at room temperature for downstream protein analysis. This product utilizes our novel Capturem technology in a spin column format with membrane-immobilized trypsin. Capturem Trypsin Columns may be used to completely digest protein samples in less than a minute with digestion efficiencies (protein coverage) comparable to or better than those obtained using in-solution trypsin digestion.

Takara Bio USA, Inc. (TBUSA, formerly known as Clontech Laboratories, Inc.) provides kits, reagents, instruments, and services that help researchers explore questions about gene discovery, regulation, and function. As a member of the Takara Bio Group, TBUSA is part of a company that holds a leadership position in the global market and is committed to improving the human condition through biotechnology. Our mission is to develop high-quality innovative tools and services to accelerate discovery.

FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES (EXCEPT AS SPECIFICALLY NOTED).