Target Details PPARG

Peroxisome proliferator-activated receptor gamma (PPARgamma) is a member of the ligand-activated nuclear receptor superfamily and functions as a transcriptional activator. PPARgamma is preferentially expressed in adipocytes as well as in vascular smooth muscle cells and macrophage. Besides its role in mediating adipogenesis and lipid metabolism , PPARgamma also modulates insulin sensitivity, cell proliferation and inflammation. PPARgamma transcriptional activity is inhibited by MAP kinase phosphorylation of PPAR gamma at Ser84.Synonyms: PPARG , PPAR gamma, CIMT1, PPARG2, PPARG1, NR1C3