James, son of Zebedee, and his brother John were among Our Lord's twelve disciples. Together with Peter, these two were privileged to behold the Transfiguration (Matthew 17:1; Mark 9:2; Luke 9:28). They witnessed the healing of Peter's mother-in-law (Mark 1:29-31) and the raising of the daughter of Jairus (Mark 5:37; Luke 8:51). Jesus called them aside to watch and pray with Him in the garden of Gethsemane on the night before His death (Matthew 26:37; Mark 14:33).

James and John may have been from a higher social level than the average fisherman. Their father could afford hired servants (Mark 1:20), and John (assuming him to be identical with the "beloved disciple") had connections with the high priest (John 18:15).

Jesus nicknamed the brothers Boanerges — Sons of Thunder — (Mark 3:17), probably commenting upon their headstrong, hot-tempered, and impulsive natures. So they seem to be in two incidents reported in the Gospels. Once, Jesus and the disciples were refused the hospitality of a Samaritan village, and James and John proposed to call down fire from heaven on the offenders (Luke 9:51-56). On another occasion, they asked Jesus for a special place of honor in the Kingdom, and were told that the place of honor is the place of suffering (Matthew 20:20-23; Mark 10:35-41).

In about AD 42, shortly before Passover (Acts 12:1-2), James was beheaded by order of Herod Agrippa I, grandson of Herod the Great (who tried to kill the infant Jesus; see Matthew 2), nephew of Herod Antipas (who killed John the Baptist — Mark 6:14-29 — and examined Jesus on Good Friday — Luke 23:6-16), and father of Herod Agrippa II (who heard the defense of Paul before Festus — Acts 25:13-26:32). James was first among the Twelve to suffer martyrdom, and the only one whose death is recorded in the New Testament.

James is often called "James Major" (also "the Greater" or "the Elder") to distinguish him from other New Testament people named James. Tradition has it that he made a missionary journey to Spain, and that after his death his body was taken to Spain and buried there at Compostela. His supposed burial place there was a major site of pilgrimage in the Middle Ages, and the Spaniards fighting to drive their Moorish conquerors out of Spain took "Santiago de Compostela!" (Saint James of Compostela) as one of their chief war-cries. (The Spanish form of "James" is Diego or Iago. In most languages, "James" and "Jacob" are identical. Where an English Bible has "James," a Greek Bible has Iakobos.

The sword (the instrument of his death) and the scallop shell are both traditional representations of the apostle.

Grant, O Lord, that as Saint James the apostle readily followed the calling of Your Son Jesus Christ, we may by Your grace be enabled to forsake all false and passing allurements and follow Him alone; through Jesus Christ, our Lord, who lives and reigns with You and the Holy Spirit, one God, now and forever.