Alterations in immunoglobulins and cytokine levels in blood of malathion poisoning cases

Authors:

Seth, VandanaBanerjee, B DAhmed, Rafat SBhattacharya, APasha, S T

Keywords:

MalathionCytokinesInterleukinsImmunoglobulinsPesticides

Issue Date:

Jun-2008

Publisher:

CSIR

Abstract:

The excessive exposure and use of malathion, an
organophosphate pesticide, has lead to deleterious effects on
human health. Chronic exposure to organophosphates has been
shown to suppress immune system in experimental animals.
Therefore, in this study, we have investigated the
immunoglobulins (IgG, IgM, IgE and IgA) and cytokines (IL-2,
IL-4, IFN-ϒ and TNF-α) levels in blood of malathion poisoning
cases, admitted in Guru Teg Bahadur Hospital (University of
Delhi), Dilshad Garden, Delhi, India. All the seriously ill patients
of malathion poisoning showed significant levels of residue
(503-702 mg/L). While no significant changes were found in Igs
levels in blood of malathion poisoning cases, there was a
significant increase in IL-2, IL-4 and TNF-α levels in blood of
malathion poisoning cases, and significant decrease in IFN-ϒ
level, as compared to normal subjects. This study demonstrated
altered levels of cytokines and interleukins in serum in response to
malathion exposure.

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