Dilacor XR (diltiazem hydrochloride)

PRECAUTIONS

Drug Interactions

(section revised) In a ten-subject randomized, open label, 4-way cross-over study, coadministration of diltiazem (120 mg twice daily diltiazem SR for 2 weeks) with a single 20 mg dose of lovastatin resulted in 3- to 4-fold higher mean lovastatin AUC and Cmax values compared with lovastatin alone. In the same study, there was no significant change in 20 mg single dose pravastatin AUC and Cmax during diltiazem coadministration.