==== Simulating selection and dominance in a non-equilibrium demography ​====

How does a population bottleneck impact the mutation burden under differing dominance and selection coefficients?​

How does a population bottleneck impact the mutation burden under differing dominance and selection coefficients?​

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Below is the code for **burden_sim**,​ a simulation of the mutation burden for two populations after a split, as described in Balick, et al., //Response to a population bottleneck can be used to infer recessive selection// (2013 preprint available here: [[http://biorxiv.org/content/early/2014/​03/​21/​003491| biorxiv]],currently under review). This simulation was also used in Do, et al., //No evidence that selection has been less effective at removing deleterious mutations in Europeans than in Africans// ([[http://​www.nature.com/​ng/​journal/​v47/​n2/​abs/​ng.3186.html|Nature Genetics 2015]]).

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Below is the code for **burden_sim**,​ a simulation of the mutation burden for two populations after a split, as described in Balick, et al., //Dominance of Deleterious Alleles Controls the Response to a Population Bottleneck// ([[http://journals.plos.org/plosgenetics/article?​id=10.1371/journal.pgen.1005436|PLOS Genetics 2015]]). This simulation was also used in Do, et al., //No evidence that selection has been less effective at removing deleterious mutations in Europeans than in Africans// ([[http://​www.nature.com/​ng/​journal/​v47/​n2/​abs/​ng.3186.html|Nature Genetics 2015]]).