The Cadillac XLR-V was the high performance version of the Cadillac XLR. Cadillac XLR-V was a ultra-luxury segment, first introduced in 2005. It was the successor to the Cadillac Allante, produced from 1987-1993. Cadillac gave the public its first glimpse of the supercharged Cadillac XLR-V in its Super Bowl commercial, which aired on February 6, 2005 Super Bowl MVP Deion Branch was also awarded with an Cadillac XLR connector. The Cadillac XLR-V was officially unveiled at the 2005 New York International Auto Show.

The Cadillac XLR-V uses the same supercharged Northstar V8 as the STS-V, although production fell slightly. For Cadillac XLR-V, the engine was certified by SAE to produce 443 horsepower (330 kW) and 414 lb·ft (561 N·m). The compressor and four inter-coolers were built in the intake manifold. An automatic six-speed gearbox, bigger Corvette Z51 brakes and 19-inch wheels were used.

The Cadillac XLR-V could accelerate to 60 mph (96 km/h) in 4.6 seconds on the evidence Car and Driver. The magazine also timed in 11.3 seconds at 100 mph (161 km/h) and recorded a quarter mile 13.0 seconds at 110 mph (177 km/h). Its top speed is electronically limited to 155 mph (249 km/h). The Cadillac XLR-V was released in the US in early 2006 with a base price of $98,000. The price for the 2008 Cadillac XLR-V model started at $101,300, making it the moment one of the most expensive cars of General Motors.