XBP-1, a transcription factor that drives the unfolded protein response (UPR), is activated in B cells when they differentiate to plasma cells. Here, we show that in the B cells, whose capacity to secrete IgM has been ...

Many large noncoding RNAs (lncRNAs) regulate chromatin, but the mechanisms by which they localize to genomic targets remain unexplored. We investigated the localization mechanisms of the Xist lncRNA during X-chromosome ...

Embryogenesis requires the timely and coordinated activation of developmental regulators. It has been suggested that the recently discovered class of histone demethylases (UTX and JMJD3) that specifically target the ...

We obtained four pointings of over 100 ks each of the well-studied Wolf-Rayet star WR 6 with the XMM-Newton satellite. With a first paper emphasizing the results of spectral analysis, this follow-up highlights the X-ray ...

Autonomous gravitational-wave searches—fully automated analyses of data that run without human intervention or assistance—are desirable for a number of reasons. They are necessary for the rapid identification of ...

The 2-deoxy-scyllo-inosamine (DOIA) dehydrogenases are key enzymes in the biosynthesis of 2-deoxystreptamine–containing aminoglycoside antibiotics. In contrast to most DOIA dehydrogenases, which are NAD-dependent, the DOIA ...

IGR J18179–1621 is an obscured accreting X-ray pulsar discovered by INTEGRAL on 2012 February 29. We report on our 20 ks Chandra-High Energy Transmission Gratings Spectrometer observation of the source performed on 2012 ...

We present a microlensing analysis of 61 Chandra observations of 14 quadruply lensed quasars. X-ray flux measurements of the individual quasar images give a clean determination of the microlensing effects in the lensing ...

We report on the Chandra X-ray Observatory and Hubble Space Telescope (HST) observations of two low core-density globular clusters, NGC6144 and E3. By comparing the number of X-ray sources inside the half-mass radius to ...

We confirm our earlier tentative detection of M31* in X-rays and measure its light curve and spectrum. Observations in 2004-2005 find M31* rather quiescent in the X-ray and radio. However, X-ray observations in 2006-2007 ...

We report on the results from the analysis of our 114 ks Chandra High Energy Transmision Grating Spectrometer observation of the Galactic core-collapse supernova remnant G292.0+1.8. To probe the three-dimensional structure ...

θ(1) Ori E is a young, moderate mass binary system, a rarely observed case of spectral-type G-giants of about 3 solar masses, which are still collapsing toward the main sequence, where they presumably become X-ray faint. ...

We report the X-ray detection of two z > 1.4 infrared-selected galaxy clusters from the IRAC Shallow Cluster Survey (ISCS). We present new data from the Hubble Space Telescope and the W. M. Keck Observatory that spectroscopically ...

We study the spectral and temporal behavior of X-ray flares from the active M dwarf EV Lac in 200 ks of exposure with the Chandra/HETGS. We derive flare parameters by fitting an empirical function which characterizes the ...

This research describes advancements in the spectral analysis and error propagation techniques associated with x-ray imaging crystal spectroscopy (XICS) that have enabled this diagnostic to be used to accurately constrain ...

We present results from continued Chandra X-ray imaging and spectroscopy of a flux-limited sample of flat spectrum radio-emitting quasars with jet-like extended structure. X-rays are detected from 24 of the 39 jets observed ...