Carotid Artery Disease

What is carotid artery disease?

The carotid arteries are the main blood vessels that carry blood and oxygen to the
brain. When these arteries become narrowed, it’s called carotid artery disease. It
may also be called carotid artery stenosis. The narrowing is caused by atherosclerosis.
This is the buildup of fatty substances, calcium, and other waste products inside
the artery lining. Carotid artery disease is similar to coronary artery disease, in
which buildup occurs in the arteries of the heart and can cause a heart attack.

Carotid artery disease reduces the flow of oxygen to the brain. The brain needs a
constant supply of oxygen to work. Even a brief pause in blood supply can cause problems.
Brain cells start to die after just a few minutes without blood or oxygen. If the
narrowing of the carotid arteries becomes severe enough that blood flow is blocked,
it can cause a stroke. If a piece of plaque breaks off it can also block blood flow
to the brain. This too can cause a stroke.

What causes carotid artery disease?

Atherosclerosis causes most carotid artery disease. In this condition, fatty deposits
build up along the inner layer of the arteries forming plaque. The thickening narrows
the arteries and decreases blood flow or completely blocks the flow of blood to the
brain.

Who is at risk for carotid artery disease?

Risk factors associated with atherosclerosis include:

Older age

Male

Family history

Race

Genetic factors

High cholesterol

High blood pressure

Smoking

Diabetes

Overweight

Diet high in saturated fat

Lack of exercise

Although these factors increase a person's risk, they do not always cause the disease.
Knowing your risk factors can help you make lifestyle changes and work with your doctor
to reduce chances you will get the disease.

What are the symptoms of carotid artery disease?

Carotid artery disease may have no symptoms. Sometimes, the first sign of the disease
is a transient ischemic attack (TIA) or stroke.

A transient ischemic attack (TIA) is a sudden, temporary loss of blood flow to an
area of the brain. It usually lasts a few minutes to an hour. Symptoms go away entirely
within 24 hours, with complete recovery. When symptoms persist, it is a stroke. Symptoms
of a TIA or stroke may include:

Sudden weakness or clumsiness of an arm or leg on one side of the body

If you or a loved one has any of these symptoms, call for medical help right away.
A TIA may be a warning sign that a stroke is about to occur. TIAs do not precede all
strokes, however.

The symptoms of a TIA and stroke are the same. A stroke is loss of blood flow (ischemia)
to the brain that continues long enough to cause permanent brain damage. Brain cells
begin to die after just a few minutes without oxygen.

The disability that occurs from stroke depends on the size and location of the brain
that suffered loss of blood flow. This may include problems with:

Moving

Speaking

Thinking

Remembering

Bowel and bladder function

Eating

Emotional control

Other vital body functions

Recovery also depends on the size and location of the stroke. A stroke may result
in long-term problems, such as weakness in an arm or leg. It may cause paralysis,
loss of speech, or even death.

The symptoms of carotid artery disease may look like other medical conditions or problems.
Always see your doctor for a diagnosis.

How is carotid artery disease diagnosed?

Along with a complete medical history and physical exam, tests for carotid artery
disease may include:

Listening to the carotid arteries. For this test, your doctor places a stethoscope over the carotid artery to listen
for a sound called a bruit (pronounced brew-ee). This sound is made when blood passes
through a narrowed artery. A bruit can be a sign of atherosclerosis. But, an artery
may be diseased without producing this sound.

Carotid artery duplex scan. This test is done to assess the blood flow of the carotid arteries. A probe called
a transducer sends out ultrasonic sound waves. When the transducer (like a microphone)
is placed on the carotid arteries at certain locations and angles, the ultrasonic
sound waves move through the skin and other body tissues to the blood vessels, where
the waves echo off of the blood cells. The transducer sends the waves to an amplifier,
so the doctor can hear the sound waves. Absence of or faintness of these sounds may
mean blood flow is blocked.

MRI scan. This procedure uses a combination of large magnets, radiofrequency energy, and a computer
to make detailed images of organs and structures in the body. For this test, you lie
inside a big tube while magnets pass around your body. It’s very loud.

Magnetic resonance angiography (MRA). This procedure uses magnetic resonance technology (MRI) and intravenous (IV) contrast
dye to make the blood vessels visible. Contrast dye causes blood vessels to appear
solid on the MRI image so the doctor can see them.

Computed tomography angiography (CTA). This test uses X-rays and computer technology along with contrast dye to make horizontal,
or axial, images (often called slices) of the body. A CTA shows pictures of blood
vessels and tissues and is helpful in identifying narrowed blood vessels.

Angiography. This test is used to assess the how blocked the carotid arteries are by taking X-ray
images while a contrast dye is injected. The contrast dye helps the doctor see the
shape and flow of blood through the arteries as X-ray images are made.

How is carotid artery disease treated?

Your healthcare provider will figure out the best treatment based on:

How old you are

Your overall health and medical history

How sick you are

How well you can handle specific medicines, procedures, or therapies

How long the condition is expected to last

Your opinion or preference

If a carotid artery is less than 50% narrowed, it is often treated with medicine and
lifestyle changes. If the artery is between 50% and 70% narrowed, medicine or surgery
may be used, depending on your case.

Medical treatment for carotid artery disease may include:

Lifestyle changes

Quit smoking. Quitting smoking can reduce the risk for carotid artery disease and cardiovascular
disease. All nicotine products, including electronic cigarettes, constrict the blood
vessels. This decreases blood flow through the arteries.

Lower cholesterol. Eat a low-fat, low-cholesterol diet. Eat plenty of vegetables, lean meats (avoid
red meats), fruits, and high-fiber grains. Avoid foods that are processed, and high
in saturated and trans-fats. When diet and exercise are not enough to control cholesterol,
you may need medicines.

Lower blood sugar. High blood sugar (glucose) can cause damage and inflammation to the lining of the
carotid arteries. Control glucose levels through a low-sugar diet, and regular exercise.
If you have diabetes, you may need medicine or other treatment.

Exercise. Lack of exercise can cause weight gain and raise blood pressure and cholesterol. Exercise
can help maintain a healthy weight and reduce risks for carotid artery disease.

Lower blood pressure. High blood pressure causes wear and tear and inflammation in blood vessels increasing
the risk for artery narrowing. Blood pressure should be below 140/90 for most people.
People with diabetes may need even lower blood pressure.

Medicines

Medicines that may be used to treat carotid artery disease include:

Antiplatelets. These medicines make platelets in the blood less able to stick together and cause
clots. Aspirin, clopidogrel, and dipyridamole are examples of antiplatelet medicines.

Cholesterol-lowering medicines. Statins are a group of cholesterol-lowering medicines. They include simvastatin and
atorvastatin. Studies have shown that certain statins can decrease the thickness of
the carotid artery wall and increase the size of the opening of the artery.

Blood pressure-lowering medicines. Several different medicines work to lower blood pressure.

If a carotid artery is narrowed from 50% to 69%, you may need more aggressive treatment,
especially if you have symptoms.

Surgery is usually advised for carotid narrowing of more than 70%. Surgical treatment
decreases the risk for stroke after symptoms such as TIA or minor stroke.

Surgical treatment of carotid artery disease includes:

Carotid endarterectomy (CEA). This is surgery to remove plaque and blood clots from the carotid arteries. Endarterectomy
may help prevent a stroke in people who have symptoms and a narrowing of 70% or more.

Carotid artery angioplasty with stenting (CAS). This is an option for people who are unable to have carotid endarterectomy. It uses
a very small hollow tube, or catheter, that is thread through a blood vessel in the
groin to the carotid arteries. Once the catheter is in place, a balloon is inflated
to open the artery and a stent is placed. A stent is a thin, metal-mesh framework
used to hold the artery open.

What are the complications of carotid artery disease?

The main complication of carotid artery disease is stroke. Stroke can cause serious
disability and may be fatal.

Can carotid artery disease be prevented?

You can prevent or delay carotid artery disease in the same way that you would prevent
heart disease. This includes:

Diet changes. Eat a healthy diet that includes plenty of fresh fruits and vegetables, lean meats
such as poultry and fish, and low-fat or non-fat dairy products, Limit your intake
of salt, sugar, processed foods, saturated fats, and alcohol.

Exercise. Aim for 40 minutes of moderate to vigorous-level physical activity at least 3 to 4
days per week.

Manage weight. If you are overweight, take steps to lose weight.

Quit smoking. If you smoke, break the habit. Enroll in a stop-smoking program to improve your chances
of success. Ask your doctor about prescription options.

Control stress. Learn to manage stress in your home and work life.

When should I call my healthcare provider?

Learn the symptoms of stroke and have your family members also learn them. If you
think you are having symptoms of a stroke, call 911 immediately.

Key points about carotid artery disease

Carotid artery disease is narrowing of the carotid arteries. These arteries deliver
oxygenated blood from the heart to the brain.

Narrowing of the carotid arteries can cause a stroke or symptoms of a stroke and should
be treated right away.

Eating a low-fat, low-cholesterol diet that is high in vegetables, lean meats, fruits,
and high fiber is one way to reduce the risk of carotid disease. Exercise, quitting
smoking, blood pressure control, and medicine can also help.

Opening the carotid arteries once they are narrowed can be done with a surgery or
with angioplasty and a stent.

Carotid artery disease may not have symptoms, but if you have significant risk factors,
see your healthcare provider for screening and diagnosis.

Next steps

Tips to help you get the most from a visit to your healthcare provider:

Know the reason for your visit and what you want to happen.

Before your visit, write down questions you want answered.

Bring someone with you to help you ask questions and remember what your provider tells
you.

At the visit, write down the name of a new diagnosis, and any new medicines, treatments,
or tests. Also write down any new instructions your provider gives you.

Know why a new medicine or treatment is prescribed, and how it will help you. Also
know what the side effects are.

Ask if your condition can be treated in other ways.

Know why a test or procedure is recommended and what the results could mean.

Know what to expect if you do not take the medicine or have the test or procedure.

If you have a follow-up appointment, write down the date, time, and purpose for that
visit.