Ass.Prof.Doz.Dr.Olaf Merkel

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know-how and research interests

Olaf Merkel is a lecturer on cancer therapeutics and an experienced biochemist. His main research interests are B and T-cell lymphomas. The focus of his group are non-coding RNAs, in particular miRNA and their impact on oncogenesis and cell survival. In particular, we are interested in the role of the oncogenic miR-155 and miR-17-92 cluster. Moreover, recently we became interested transcription factors regulating cell growh and cytokines expression like cJUN and BATF. Also how cytokine signals are then transduced to the nucleus using the JAK/STAT pathway. Kinases in this pathway are potential therpeutic targets.