Available hosts

Available applications

Background of TRIM38 / RNF15 antibody

The RING-type zinc finger motif is present in a number of viral and eukaryotic proteins and is made of a conserved cysteine-rich domain that is able to bind two zinc atoms. Proteins that contain this conserved domain are generally involved in the ubiquitination pathway of protein degradation. RNF152 (RINGfinger protein 152) is a 203 amino acid protein that contains one RING-type zinc finger and may be involved in protein degradation events throughout the cell. The gene encoding RNF152 maps to human chromosome 18, which houses over 300 protein-coding genes and contains nearly 76 million bases. There are a variety of diseases associated with defects in chromosome 18- localized genes, some of which include Trisomy 18 (also known as Edwards syndrome), Niemann-Pick disease, hereditary hemorrhagic telangiectasi,a erythropoietic protoporphyria and follicular lymphomas.