The association between Interleukin-23R gene polymorphism and Crohn’s disease CD in Caucasians is still controversial. Thus, a meta-analysis was performed to evaluate the correlation between this gene variant and CD risk. We retrieved the available data from EMBASE and PUBMED until May 1, 2014, and evaluated the effect of rs7517847 in Caucasians. The significant associations were confirmed between rs7517847 and CD risk in dominant models TT-TG versus GG: OR = 1.652, 95% CI 1.277, 2.137, allelic model T allele versus G allele: OR = 1.327, 95% CI 1.198, 1.469, homozygote comparison TT versus GG: OR = 1.890, 95% CI 1.465, 2.437, heterozygote comparison TG versus GG: OR = 1.509, 95% CI 1.161, 1.960, and recessive model TT versus TG-GG: OR = 1.409, 95% CI 1.279, 1.552. In conclusion, this meta-analysis demonstrates that rs7517847 is associated with the risk of CD in Caucasians. These findings show that IL-23R genes confer susceptibility to CD in the Caucasians.