Colorectal carcinoma CRC is a major public health problem as the third leading malignant tumor in men and fourth in women in Croatia. Prognosis and treatment greatly depend on tumor stage at the time of detection. Therefore, the National Program of Colorectal Carcinoma Early Detection has been performed since 2007. The aim is to present the response rate, colonoscopy findings and number of newly detected CRC cases in Brod-Posavina County. During five years of the National Program performance, 28 CRC cases were detected in Brod-Posavina County, with the 3.3‰ rate of carci- noma detection. The majority of CRC cases were found in the 50–64 age group. The response rate in the County was low 20.4%, corresponding to the national rate but far from the recommended one. Such a result could be attributed to the low level of awareness in the population at large, complex testing technique for general population, fear from disease de- tection and from colonoscopy as a diagnostic procedure. Note should be made of the underestimated role of family physi- cians; their involvement in the National Program should certainly result in better response rate in our County as well as at the national level.