In this paper we report on a case of a 45 year–old woman who is sensitive to palladium and nickel. She was referred to our department via the Internal Medicine department. She not only had symptoms of dermatitis on her facial and palmar skin, but also general malaise, pyrexia and dyspnea. Symptom patterns suggested critical flare-ups after the removal of dental alloys at a private dental office. In cooperation with the Internal Medicine department which specializes in connective tissue disease, we removed the dental alloys and performed a root canal treatment under administration of steroids. She progressed favorably with metal-free restorations. At the first visit, she had mild edematous swelling on her facial and palmar skin. She had six dental alloy restorations and her oral mucosa was clear. The next day, to remove the remaining dental alloys, 100mg/day of hydrocortisone and 6mg/day of d-chlorpheniramine was administered before the dental treatment under hospitalization. The course of treatment was uneventful. But after the root canal treatment she presented multiple episodes of allergic reactions. According to the instructions of the Internal Medicine department, she received administration of hydrocortisone and d-chlorpheniramine as prophylactics. Consequently, she showed no allergic symptoms in the course of treatment. Six months later, we replaced the alloy restorations with metal-free restorations. The dermal lesions resolved, and there was no recurrence two years after removal of the dental alloys.