Computerized data on all first-time blood donors in a large network of United States blood centers was examined during the period 2000-2009. HTLV-I/II antibody was measured by enzyme immunoassay (EIA), with supplemental testing of all reactive samples using an EIA from an alternate manufacturer. Prevalence rates were calculated, and odds ratios (OR) and 95% confidence intervals (CI) for associations with demographic characteristics were assessed using multivariate logistic regression.

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