The 2009 Tour of Missouri took place September 7–13, 2009 as part of 2008-2009 UCI America Tour and the 2009 USA Cycling Professional Tour. Missouri state officials intended to support the Tour for three years, with the intention of making it an annual event. However, the 2009 Tour was almost canceled when its funds were provisionally cut from the state's tourism budget. Funds were restored when breach-of-contract fees to teams threatened to total more than the $1.5 million that it would cost the state to finance the race.

The Sprint Leader Jersey is a gray and Green Jersey is worn by the rider that receives the most bonus points awarded through his placing in intermediate sprints and finishing in the top 15 places at the end of the stage.

The King of the Mountains Jersey is worn by current leader and overall winner by points awarded by his placing in mountain climbs. The leader wears a medium-blue jersey with yellow accents and is sponsored by Michelob ULTRA.

The Most Aggressive Rider wears the Red Jersey. The jersey is awarded at the end of each stage to the rider that demonstrates the most aggressive attacks, breakaways or strategies, as judged by a panel of media and race entourage officials.