Cholecalciferol

Poisonous to: Cats, Dogs

Level of toxicity: Generally moderate to severe

Common signs to watch for:

Lethargy

Inappetance

Weakness

Increased thirst and urination

Halitosis

Organ failure

This is one of the most dangerous mouse and rat poisons on the market and unfortunately, seems to be gaining in popularity. Cholecalciferol, or activated vitamin D3, causes a life-threateningly high calcium and phosphorus level in the body, resulting in severe, acute kidney failure. This can progress to chronic kidney failure and have long-term repercussions. Common signs of poisoning may not be evident for 1-2 days, when the poison has already resulted in significant -and potentially permanent – damage to the body. Increased thirst and urination, weakness, lethargy, a decreased appetite, and halitosis (“uremic” breath) may be seen. Acute kidney failure develops 2-3 days after ingestion of this type of mouse and rat poison.

Unfortunately, cholecalciferol mouse and rat poison does not have an antidote, and is one of the most challenging poisoning cases to treat as hospitalization, frequent laboratory monitoring and expensive therapy is often required for a positive outcome. Treatment includes aggressive IV fluids (for 2-3 days) and specific drugs (e.g., diuretics, steroids, calcitonin and bisphosphonates) to decrease calcium levels in the body. Frequent monitoring of blood work (calcium, phosphorus, and kidney values) is often needed for a period of 2-6 weeks after ingestion.

Unfortunately, cholecalciferol has a very narrow margin of safety, which means that even small ingestions of this poison can result in severe clinical signs or death. Toxic ingestions must be treated quickly and appropriately to prevent kidney failure.

Poison type: Garage Items

Alternate names: Vitamin D3, calcitriol, calcipotriene

Pictured: Cholecalciferol

The latest…

Who we are...

Pet Poison Helpline is a 24-hour animal poison control service available throughout the U.S., Canada, and the Caribbean for pet owners and veterinary professionals who require assistance with treating a potentially poisoned pet. We have the ability to help every poisoned pet, with all types of poisonings, 24 hours a day. Our knowledge and expertise of pet poisons will put your mind at ease when dealing with a potential emergency.

In order to provide this critical service, please be advised that there is a $59 per incident fee, payable by credit card. This fee covers the initial consultation as well as all follow-up calls associated with the management of the case.