The purpose of this study is to evaluate the superiority regarding vitreomacular adhesion (VMA) resolution of a single intravitreal injection of A01016 (Ocriplasmin) compared to sham-injection in subjects with symptomatic VMA.

Proportion of Subjects With Non-Surgical Resolution of Vitreomacular Adhesion (VMA) [ Time Frame: Day 28 ] [ Designated as safety issue: No ]

VMA (adhesion of the vitreous gel to the retina in an abnormally strong manner) was determined by masked Central Reading Center (CRC) Spectral Domain Optical Coherence Tomography (SD-OCT) evaluation. Only one eye (study eye) was analyzed. Proportion of subjects is reported as a percentage.

Pregnant or of child-bearing potential and not utilizing acceptable form of contraception;

Participation in another investigational drug study within 30 days prior to this study;

Other protocol-defined exclusion criteria may apply.

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Please refer to this study by its ClinicalTrials.gov identifier: NCT01889251