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Polarimetry and spectropolarimetry are important tools in the sugar industry and pharmaceutical research. Polarimetric measurements cannot be performed on colored samples because the presence of color interferes with the ...

The synthesis, characterization and analysis of novel chiral molecules advance many areas of synthetic organic chemistry, both industrially and academically. This work touches on three of the major methods for obtaining ...

Our lab has long had an interest in the potential biomedical applications of naphthalimide photochemistry, including especially the use for the bonding and modification of fresh tissue. Photochemical tissue bonding represents ...

Since biological processes depend on the stereospecific creation and conversion of chiral molecules, each enantiomer of a molecule can have a different biological effect. While numerous synthetic drugs are sold in racemic ...

Pathogenic bacteria are rapidly becoming antibiotic resistant, at a rate much faster than the production and FDA approval of new antibiotics that can combat these extreme resistant infections. One way to overcome antibiotic ...

This dissertation will focus on the development of a novel technique to study the kinetics and dynamics of transition metal ion assisted σ-bond activation of gaseous organic molecules. The measurements reported represent ...

Aptamers are oligonucleotides that bind with great specificity and affinity to a target molecule. These oligonucleotides are produced through the course of Systemic Evolution of Ligands by Exponential Enrichment (SELEX). ...

The exploration of Saturn's moon, Titan has revealed an atmosphere rich in nitrogen as in Earth, and has established the presence of gaseous methane. Data from the Cassini-Huygens mission have shown the existence of liquid ...

Inhibition of tubulin polymerization has been identified as a significant characteristic of potential anticancer agents. Tubulin is a heterodimeric protein of a and b polypepetide chains, each with a molecular weight of ...

The purification and study of proteins are cooperative processes because at least partially purified protein is needed in order to study its properties, and certain information about the protein's properties is required ...

The enantiomeric composition of samples was determined using spectroscopy and multivariate regression modeling. Partial least-squares (PLS-1) regression models were developed from the spectral data of solutions containing ...

Pulsed photoionization in a supersonic expansion was investigated for the production of intense ionic cluster beams from seeded organic molecules. Neutral clusters were photoionized in a pulsed system and studied by means ...

The development of new chiral ligands for asymmetric catalysis is an increasingly important area of research. Though many ligands are phosphorus based, one class of phosphorus ligands, phosphinines (phosphabenzenes), have ...

Phosphorus ligands are well recognized for stabilizing metal complexes in a variety of oxidation states and coordination geometries.1 Compounds with pyridyl containing phosphines have been investigated with carbinol groups ...

Reaction of the fragments {Ir(PEt₃)n}⁺ with the monocarborane anion [closo-1-CB₇H₈]⁻ causes an oxidative insertion to occur, and the iridium moiety to become a cluster vertex. This reaction provides two distinct, neutral, ...

The coordination properties of the bifunctional ligand 2-[(diphenylphosphino)methyl]pyridine, its two corresponding oxides, and the ligand 4-[(diphenylphosphino)methyl]pyridine towards different transition metal salts are ...

The technology for conversion of lignocellulosic biomass resources to fuels and chemicals has been under development for decades. There are many process configurations for conversion of biomass to ethanol, one of the ...

Despite the versatility of pyrylium salts as precursors to many heteroaromatic
systems, chiral pyrylium salts are almost unknown in the literature. One reason for this
scarcity is that pyrylium salts are often involved ...

Over the past 10 years a number of catalytically active single-stranded DNA molecules (deoxyribozymes) have been isolated from combinatorial libraries (pools) of randomized oligonucleotides. These enzyme-like DNAs customarily ...

Cancer is a leading cause of death in men and women under in the United States and is characterized by uncontrolled cellular proliferation and migration (metastasis) which can impinge on surrounding organs, modify ordinary ...