Oxymorphone CII

Narcotic analgesics:

Indications for Oxymorphone:

Management of acute pain severe enough to require an opioid analgesic and for which alternative treatment options are inadequate.

Adult:

Use lowest effective dose for shortest duration. Individualize. Take on empty stomach. May give immediate-release (IR) tab as needed on an every 4–6hrs schedule; ext-rel tab is given on a continuous basis every 12hrs. ≥18yrs: Opioid-naive: IR tab: 10–20mg every 4–6hrs as needed. Ext-rel tab: Swallow whole; 5mg every 12hrs, titrate by 5–10mg every 12hrs every 3–7 days; if breakthrough pain occurs: adjust dose or use a small-dose rescue medication (eg, IR oxymorphone). Converting from IR tab to ext-rel tab: Give half the total daily IR tab dose as ext-rel tab every 12hrs. Conversion from other opioids: see full labeling. Mild hepatic impairment, renal impairment (CrCl <50mL/min), or elderly (≥65yrs): opioid-naive: initiate with 5mg dose; opioid-experience: initiate at 50% lower than normal starting dose and titrate slowly. Concomitant other CNS depressants: initiate at ⅓–½ of usual starting dose and monitor. Withdraw gradually (esp. if opioid-dependent), taper by ≤10–25% every 2–4 weeks.

Children:

<18yrs: not established.

Contraindications:

Significant respiratory depression. Acute or severe bronchial asthma in an unmonitored setting or in the absence of resuscitative equipment. Known or suspected GI obstruction, including paralytic ileus. Moderate to severe hepatic impairment.

Elimination:

REMS:

How Supplied:

Pricing for Oxymorphone

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