Only in so much as they are both cattle....
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Buffalo and bison are not the same animal. Typically, the big fluffy animals that people call buffalo are actually bison, while true buffalo look more like large bulls. The two are related though. Bison and buffalo are bovines (a subfamily of bovids), but bison are in a different genus from buffalo. Other relatives include antelopes, cattle, goats and sheep.

There are two different species of bison: the American bison and the European bison. The American bison became the official national mammal of the United States when President Barack Obama signed the National Bison Legacy Act into law on May 9, 2016, according to the U.S. Department of the Interior.

Size
The American bison is the largest mammal in North America. It grows to 7 to 11.5 feet (2.1 meters to 3.5) long from head to rump, and its tail adds an extra 20 to 23.5 inches. They weigh 930 to 2,200 lbs. (422 to 998 kilograms).

Yes and no. Yes, they both belong to the Family Bovidae. No, the Bison belongs to the Sub-family Bovinae (cattle and their relatives) and the Musk Ox to the Sub-family Caprinae (Sheep and goats and their relatives)

This looks good so far chris.
love the wisent (european bison)....looks tough and is it bigger than american bison?
Also chris, shouldn't there also be thick hair on the hump and shoulders too? Looks too the beard is wider on chin and neck looking like the sides of head transition down too and not just from beneath the chin?

Which one? Eurasian (Bos primigenius primigenius), Indian (Bos primigeniusnamadicus) or North African (Bos primigeniusafricanus)? The North African resembles the Eurasian in its morphology. The Eurasian auroch gave rise to the European or taurine cattle (Bos taurus taurus) while the Indian auroch gave rise to the zebu or indicine or humped cattle (Bos taurus indicus).

Reconstruction of Eurasian auroch, (Bos primigenius primigenius)

Reconstruction of Indian auroch (Bos primigeniusnamadicus)

My own wish is for a zebu (Bos taurus indicus):

Or this Malaysian variety (Kedah Kelantan zebu) which is the bull that is most familiar to me:

Which one? Eurasian (Bos primigenius primigenius), Indian (Bos primigeniusnamadicus) or North African (Bos primigeniusafricanus)? The North African resembles the Eurasian in its morphology. The Eurasian auroch gave rise to the European or taurine cattle (Bos taurus taurus) while the Indian auroch gave rise to the zebu or indicine or humped cattle (Bos taurus indicus).