The Gold Standard In Nootropics

“Man will not wait passively for millions of years for evolution to offer him a better brain.”

-Corneliu Giurgea, 1972

In 1972 Corneliu Gurgea wrote the above words after discovering a new class of substances that enhanced learning and memory, yet were extremely safe and protective of the brain, he called these substances nootropics.

Nootroo is the realization of this concept in a once daily pill formulated with a synergistic blend of the best nootropic substances available on the market.

To be considered a nootropic, a substance must meet ALL of the following characteristics:

Enhance learning and memory

Have few side effects and extremely low toxicity

Protect the brain from physical or chemical injury like concussions, barbiturates or scopolamine

Enhance the firing mechanisms of neurons

Prevent the disruption of learned behaviors and memory formation to conditions which tend to disrupt them, such as electroconvulsive shock or hypoxia.

*Amphetamines like Adderall and wakefulness-agents like Modafinil are NOT considered nootropics.

Testimonials

“With Nootroo I’m able to stay in the zone all day and after work I have the energy to keep going.” -Kostika S, 3D Modeler at Shapeways

“I’ve been taking it everyday and I’m feeling very sharp. I’ve also been able to cut back on my coffee consumption.” -Chad F, CEO Fudali Apparel

“I definitely feel its effectiveness in my daily life, Nootroo is the real deal!” -Vishal A., General Manager & Head of Sales, PHHHOTO

Single Month Supply

$ 64.95

Ingredients and Instructions

Nootroo comes in two different formulas, a Gold formula and a Silver formula. The two formulas differ only in the main ingredient, which in the Gold is Noopept and in the Silver is Phenylpiracetam. Both formulas contain CDP-Choline and our proprietary ratio of L-Theanine & Caffeine, called SmoothCaffeine. The pills are alternated between, one day gold, and the next day silver. To distinguish between the two formulas without using artificial colorings, the Gold formula contains edible, pure 23.5 carat gold flakes and the silver formula contains edible, 100% pure silver flakes. For fastest action, take the capsule on an empty stomach at least 30 minutes prior to eating.

Noopept

Noopept has been shown in animal studies to be neuroprotective and to help to enhance and restore memory1)Ostrovskaya RU, Romanova GA, Barskov IV, Shanina EV, Gudasheva TA, Victorov IV, Voronina TA, Seredenin SB (1999). “Memory restoring and neuroprotective effects of the proline-containing dipeptide, GVS-111, in a photochemical stroke model”. Behavioural Pharmacology10 (5): 549–553.doi:10.1097/00008877-199909000-00013.PMID10780261. In studies with the Alzheimer’s disease model, Noopept has restored spatial memory and increased immunoreactivity to amyloid buildup. 2)Ostrovskaya RU, Gruden MA, Bobkova NA, Sewell RD, Gudasheva TA, Samokhin AN, Seredinin SB, Noppe W, Sherstnev VV, Morozova-Roche LA (2007). “The nootropic and neuroprotective proline-containing dipeptide noopept restores spatial memory and increases immunoreactivity to amyloid in an Alzheimer’s disease model”. Journal of Psychopharmacology21 (6): 611–619.doi:10.1177/0269881106071335. 17092975. Studies also show Noopept to stimulate the expression of Nerve Growth Factor (NGF) and Brain-Derived Neurotropic Factor (BDNF) in the hippocampus and cerebral cortex. The hippocampus is the region of the brain responsible for the formation of memories and consolidation of short-term memory to long-term memory. BDNF is a protein that is crucial in determining the quantity of new neurons the brain can create, as well as regulating growth, survival and, differentiation of existing neurons.3)” We showed that the nootropic drug increases expression of neurotrophic factors in the hippocampus. Our results are consistent with the hypothesis that neurotrophin synthesis in the hippocampus determines cognitive function, particularly in consolidation and delayed memory retrieval. Published data show that neurotrophic factor deficiency in the hippocampus is observed not only in advanced Alzheimer’s disease, but also at the stage of mild cognitive impairment (predisease state). In light of this our findings suggest that Noopept holds much promise to prevent the development of Alzheimer’s disease in patients with mild cognitive impairment. Moreover, therapeutic effectiveness of Noopept should be evaluated at the initial stage of Alzheimer’s disease.” http://link.springer.com/article/10.1007%2Fs10517-008-0297-x

Phenylpiracetam

Phenylpiracetam is a nootropic substance that has been shown to improve cognition in persons with cognitive decline from organic causes.4)Lybzikova GN, Iaglova ZhS, Kharlamova IuS. The efficacy of phenotropil in the complex treatment of epilepsy. Zh Nevrol Psikhiatr Im S S Korsakova. (2008) It has also been shown to improve cognition in youth with epilepsy. In rodent trials Phenylpiracetam has been shown to improve retention latency by over 185%. 5)Zvejniece L, et al. Investigation into stereoselective pharmacological activity of phenotropil. Basic Clin Pharmacol Toxicol. A single dose of phenylpiracetam has been shown to cause a “significant increase in locomotor activity” and a ‘significantly enhanced memory function in a passive avoidance response test” in rodents. 6)Zvejniece L, et al. Investigation into stereoselective pharmacological activity of phenotropil. Basic Clin Pharmacol Toxicol. (2011) Phenylpiracetam has also been shown to be effective in increasing physical endurance, adaptation and resistance to cold. 7) “Carphedon is a phenyl derivative of nootropil and is effective in increasing physical endurance and cold resistance, and is used for amnesia treatment.” Analyst. 1999 Nov;124(11):1559-62. PMID: 10746314.

The following ingredients are found in both the silver and gold capsules.

Caffeine

Caffeine is the most widely used Nootropic in the world, consumed daily by up to 80% of American adults through coffee, tea, and soft drinks. Caffeine is found in nature in seeds, leaves and fruits of plants, where it is actually a natural pesticide and a reward to pollinators such as bees. Caffeine is a central nervous system stimulant 22)Nehlig A, Daval JL, Debry G (1992). “Caffeine and the central nervous system: mechanisms of action, biochemical, metabolic and psychostimulant effects”. Brain Res. Brain Res. Rev.17 (2): 139–70.doi:10.1016/0165-0173(92)90012-B. PMID1356551.. It has the ability to reduce physical fatigue and restore alertness. Caffeine produces increased wakefulness, faster and clearer flow of thought, increased focus, and better general body coordination. 23)Bolton S (1981). “Caffeine: Psychological Effects, Use and Abuse”. Orthomolecular Psychiatry10 (3): 202–211.. The level of caffeine in Nootroo is equivalent to about one cup of coffee, but because it is blended with L-Theanine in the SmoothCaffeine formulation, the effects are different than having caffeine by itself. The L-Theanine removes negative side-effects associated with caffeine such as jitters, anxiety, and crashes. The combination of caffeine with L-Theanine, is better than consuming either ingredient by itself.

” We showed that the nootropic drug increases expression of neurotrophic factors in the hippocampus. Our results are consistent with the hypothesis that neurotrophin synthesis in the hippocampus determines cognitive function, particularly in consolidation and delayed memory retrieval. Published data show that neurotrophic factor deficiency in the hippocampus is observed not only in advanced Alzheimer’s disease, but also at the stage of mild cognitive impairment (predisease state). In light of this our findings suggest that Noopept holds much promise to prevent the development of Alzheimer’s disease in patients with mild cognitive impairment. Moreover, therapeutic effectiveness of Noopept should be evaluated at the initial stage of Alzheimer’s disease.” http://link.springer.com/article/10.1007%2Fs10517-008-0297-x

“Carphedon is a phenyl derivative of nootropil and is effective in increasing physical endurance and cold resistance, and is used for amnesia treatment.” Analyst. 1999 Nov;124(11):1559-62. PMID: 10746314

Raloff, Janet (September 29, 2007).“Distracted? Tea might help your focus”.Science News172 (13): 206.doi:10.1002/scin.2007.5591721319. “John J. Foxe of the Nathan S. Kline Institute for Psychiatric Research in Orangeburg, N.Y., and his colleagues recruited 16 people for tests of attentiveness on four days. Before testing, each individual drank a glass of water. On 3 days, the drink was spiked with 100 milligrams of theanine, 60 mg of caffeine, or both. The theanine dose was equivalent to that in 4 to 5 cups of tea, and the caffeine translated to about 2.5 cups of tea. In the difficult tests, participants watched a computer screen and pressed a button when a designated shape appeared on the side of a busy visual field to which an arrow had previously pointed. Participants’ accuracy differed little between days when they got water alone or with only one additive. Accuracy improved dramatically, however, on the day that they got the theanine-caffeine combination. The attention benefit lasted throughout the 3 hours of testing.”

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Nootroo™ and SmoothCaffeine™ are Trademarks of Nootroo LLC. Suntheanine® is a registered trademark of Taiyo International, Inc. Cognizin® is a registered trademark of KYOWA HAKKO BIO CO., LTD. PURENERGY™ is a trademark of Chromadex, Inc., Patents: See:www.ChromaDexPatents.com. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Nootroo is for adults aged 18 and older. If you are pregnant or undergoing treatment for a medical condition, please consult your physician before taking Nootroo. Phenylpiracetam and noopept are not vitamins, minerals, amino acids, herbs or other botanical, or dietary substances for use by man to supplement the diet by increasing the total dietary intake. Nootroo contains high purity research chemicals intended for use in neuroscience research only.