I remember when it was first being developed - it was apparently set to be like an opioid with the added benefit of Cymbalta.

There are some big drawbacks though - it can't be used with SNRIs or SSRIs.

The analgesic effect (from trials) has been shown to be somewhat weaker than oxy, morphine etc but they say that the added SNRI action has a potentiating effect making it almost as effective. There are also reports of less gastrointestinal side effects.

Where does it sit price wise? Just if you know off the top of your head.

Hello Brian.
My doctor just prescribed NUCYNTA to me , I am in constant pain due to back problems.. I had 2 surrgeries in the last 2 years {2 level fusion and a 4 level lamenectomie}..

I just took my first dose (50mgs) , and will see how it works out - with my insurance it coast me $50.00 for 120 of them.. It is supposed to be a very good medication for people suffering with back pain , have you tried it yet ?