The new hospital is the centerpiece of an effort, launched in 2004, to transform both the campus and how Rush provides medical care. The Rush Transformation includes new and renovated buildings designed to better support patient needs, as well as advanced information systems that will improve the quality, safety and efficiency of patient care.

The Rush Transformation is the most comprehensive construction and facilities renovation program in Rush's more than 174-year history​. In addition to the new hospital, key Transformation projects include: