T-Maze Continuous Alternation Task (T-CAT) in mice

Presentation

The T-maze continuous alternation task (T-CAT) is among the method implemented to evaluate the spatial exploratory performance in mice. The procedure relies on the animal's natural behaviour to explore novelty and thus alternate between right and left arms.

When used in conjunction with pharmacological tools, the system allows to evaluate memory deficit (reduction in the number of alternation) useful as model for screening compounds with cognitive enhancing properties.

Deficits induced by scopolamine in 3 mouse strains as assayed in the T-maze

Reversion of scopolamine-induced deficit

by Donepezil (0.003 to 0.3 mg/kg) in Swiss mice in the T-maze.

Reversion of scopolamine-induced deficit

by Donepezil (0.1 to 0.5 mg/kg) iin Swiss mice in the T-maze.

Reversion of scopolamine-induced deficit

by Nicotine in Swiss mice in the T-maze.

Amphetamine :

Reversal effect of Amphetamine on cognitive deficit induced by scopolamine in the mouse. Cognitive function was assessed by the ability of mice to perform spontaneous, continuous and sustained alternation in the T-maze.

Atomoxetine :

Reversal effect of Atomoxetine on cognitive deficit induced by scopolamine in the mouse. Cognitive function was assessed by the ability of mice to perform spontaneous, continuous and sustained alternation in the T-maze.

Caffeine :

Reversal effect of Caffeine on cognitive deficit induced by scopolamine in the mouse. Cognitive function was assessed by the ability of mice to perform spontaneous, continuous and sustained alternation in the T-maze.

CCMI :

Reversal effect of CCMI on cognitive deficit induced by scopolamine in the mouse. Cognitive function was assessed by the ability of mice to perform spontaneous, continuous and sustained alternation in the T-maze.

Galantamine :

Reversal effect of Galantamine on cognitive deficit induced by scopolamine in the mouse. Cognitive function was assessed by the ability of mice to perform spontaneous, continuous and sustained alternation in the T-maze.

Methylphenidate :

Reversal effect of Methylphenidate on cognitive deficit induced by scopolamine in the mouse. Cognitive function was assessed by the ability of mice to perform spontaneous, continuous and sustained alternation in the T-maze.

Nicotine :

Reversal effect of Nicotine on cognitive deficit induced by scopolamine in the mouse. Cognitive function was assessed by the ability of mice to perform spontaneous, continuous and sustained alternation in the T-maze.

PNU120596 :

Reversal effect of PNU120596 on cognitive deficit induced by scopolamine in the mouse. Cognitive function was assessed by the ability of mice to perform spontaneous, continuous and sustained alternation in the T-maze.

Reversion of MK-801-induced cognitive deficit in the T-Maze alternation task in the mouse

Carbamazepine :

Reversal effect of Carbamazepine on cognitive deficit induced by MK-801 in the mouse. Cognitive function was assessed by the ability of mice to perform spontaneous, continuous and sustained alternation in the T-maze.

Clozapine :

Reversal effect of Clozapine on cognitive deficit induced by MK-801 in the mouse. Cognitive function was assessed by the ability of mice to perform spontaneous, continuous and sustained alternation in the T-Maze.

Xanomeline :

Reversal effect of Xanomeline on cognitive deficit induced by MK-801 in the mouse. Cognitive function was assessed by the ability of mice to perform spontaneous, continuous and sustained alternation in the T-maze.