Nuvo Pharmaceuticals™ Inc. Appoints Jesse Ledger as President

MISSISSAUGA, ON, Nov. 16, 2016 /PRNewswire/ - Nuvo Pharmaceuticals Inc. (Nuvo or the Company) (TSX:NRI), formerly Nuvo Research Inc., a commercial healthcare company with a portfolio of commercial products and pharmaceutical manufacturing capabilities, today announced that its board of directors has appointed Jesse Ledger to the position of President effective immediately.

Mr. Ledger was previously Nuvo's Vice-President of Business Development. In his new role, Mr. Ledger will assume additional operational responsibilities and lead the Company's initiative to diversify its revenue streams by out-licensing global rights for its lead product, Pennsaid 2% and by acquiring complementary products or businesses. John London, who was previously Nuvo's President and Chief Executive Officer will continue to lead the Company as its CEO.

"Jesse is an extremely talented executive who has demonstrated an expansive knowledge of the pharmaceutical industry and strong organizational and leadership qualities," said John London, Nuvo's CEO. "We are pleased to expand his responsibilities and entrust him with the Company's highest priority strategic initiative of expanding and diversifying Nuvo's revenue stream."

Mr. Ledger joined Nuvo in April 2016 as its Vice-President of Business Development. Prior to joining Nuvo, he was Vice-President, Business Development and International Business of Tribute Pharmaceuticals Canada Inc. While at Tribute, Mr. Ledger was a member of the senior management team that completed six transactions with an aggregate value of over CDN$250 million, culminating in a merger with Pozen Inc. and the subsequent formation of Aralez Pharmaceuticals plc. Prior to joining Tribute, Mr. Ledger was the Director, Business Development at SteriMax Inc. Mr. Ledger holds an honours Bachelor of Business Administration degree from Trent University.

About Nuvo Pharmaceuticals Inc.Nuvo (TSX:NRI) is a commercial healthcare company with a portfolio of commercial products and pharmaceutical manufacturing capabilities. Nuvo has three commercial products that are available in a number of countries; Pennsaid 2%, Pennsaid and the heated lidocaine/tetracaine patch. Pennsaid 2% is sold in the U.S. by Horizon Pharma plc (NASDAQ: HZNP) and is available for partnering in certain other territories around the world. Nuvo manufactures Pennsaid for the global market and Pennsaid 2% for the U.S. market at its FDA, Health Canada and E.U. approved manufacturing facility in Varennes, Québec. For additional information, please visit www.nuvopharmaceuticals.com.

Forward-Looking Statements Certain statements in this press release constitute forward-looking information and/or forward-looking statements (collectively, "forward-looking statements") within the meaning of applicable securities laws. Forward-looking statements include, but are not limited to, the future approval, marketing and sale of Pennsaid 2% in certain jurisdictions, as well as statements with respect to management's beliefs, plans, estimates, and intentions, and similar statements concerning anticipated future events, results, circumstances, performance or expectations that are not historical facts. Forward-looking statements generally can be identified by the use of forward-looking terminology such as "may", "will", "expect", "intend", "believe", "should" or "plans", or similar expressions suggesting future outcomes or events. Such forward-looking statements reflect management's current beliefs and are based on information currently available to management. Forward-looking statements involve risks and uncertainties that could cause actual results to differ materially from those contemplated by such statements. Factors that could cause such differences include, but are not limited to, general business and economic uncertainties and adverse market conditions; as well as other risk factors included in the Company's Management Information Circular dated December 31, 2015 and the Company's Annual Information Form dated February 17, 2016 under the heading "Risks Factors", and as described from time to time in the reports and disclosure documents filed by the Company with Canadian securities regulatory agencies and commissions. These and other factors should be considered carefully and readers should not place undue reliance on the Company's forward-looking statements. As a result of the foregoing and other factors, no assurance can be given as to any such future results, levels of activity or achievements and neither the Company nor any other person assumes responsibility for the accuracy and completeness of these forward-looking statements. Although the forward-looking information contained in this press release is based upon what management believes are reasonable assumptions, there can be no assurance that actual results will be consistent with these forward-looking statements. All forward-looking statements in this press release are qualified by these cautionary statements. The forward-looking statements contained herein are made as of the date of this press release and, except as required by applicable law, the Company undertakes no obligation to publicly update or revise any forward-looking statement, whether as a result of new information, future events or otherwise.