BACKGROUND: The aim of the study was to evaluate the influence of nutritional
status on outcome of elderly patients resected for lung cancer.
MATERIALS AND METHODS: A total of 117 consecutive patients aged ≥ 70 years
undergoing lung cancer resection were enrolled. In addition to routine
preoperative evaluations, other variables such as body mass index, weight loss,
serum albumin, lymphocytes, and transferrin were counted. According to the body
mass index value, patients were divided into Group A (≤ 18.5, underweight) and
Group B (> 18.5) and risk factors for morbidity and mortality were analyzed.
RESULTS: Group A and Group B counted 21 and 96 patients, respectively. The mean
age was 74.9 ± 2.6; body mass index of Group A was significantly lower than that
of Group B (16.7 ± 1.3 vs. 23.5 ± 1.7, respectively, p < 0.0001). On multivariate
analysis, significant risk factors for complications were pneumonectomy
(p = 0.001), stage (p = 0.006), predictive postoperative flow expiratory volume
in 1 second (ppoFEV1%) (p = 0.003), and coronary disease (p = 0.04) and
significant risk factors for early mortality were pneumonectomy (p = 0.0002),
ppoFEV1% (p < 0.0001), BMI (0.02), and weight loss (0.007). The median survival
time of Group A and Group B was 41 versus 54 months, respectively (p = 0.1).
However, body mass index of less than 18.5 (p = 0.01) and weight loss of > 5%
before operation (p = 0.01) were independent risk factors for 1 year mortality.
CONCLUSIONS: In elderly patients, malnutrition was a significant additional risk
factor for early death. Nutritional assessment should be included in the routine
preoperative selection. In malnourished patients, nutritional support before and
after operation and a careful postdischarge care might be beneficial, but it
should be corroborated by further prospective studies.

BACKGROUND: The aim of the study was to evaluate the influence of nutritional
status on outcome of elderly patients resected for lung cancer.
MATERIALS AND METHODS: A total of 117 consecutive patients aged ≥ 70 years
undergoing lung cancer resection were enrolled. In addition to routine
preoperative evaluations, other variables such as body mass index, weight loss,
serum albumin, lymphocytes, and transferrin were counted. According to the body
mass index value, patients were divided into Group A (≤ 18.5, underweight) and
Group B (> 18.5) and risk factors for morbidity and mortality were analyzed.
RESULTS: Group A and Group B counted 21 and 96 patients, respectively. The mean
age was 74.9 ± 2.6; body mass index of Group A was significantly lower than that
of Group B (16.7 ± 1.3 vs. 23.5 ± 1.7, respectively, p < 0.0001). On multivariate
analysis, significant risk factors for complications were pneumonectomy
(p = 0.001), stage (p = 0.006), predictive postoperative flow expiratory volume
in 1 second (ppoFEV1%) (p = 0.003), and coronary disease (p = 0.04) and
significant risk factors for early mortality were pneumonectomy (p = 0.0002),
ppoFEV1% (p < 0.0001), BMI (0.02), and weight loss (0.007). The median survival
time of Group A and Group B was 41 versus 54 months, respectively (p = 0.1).
However, body mass index of less than 18.5 (p = 0.01) and weight loss of > 5%
before operation (p = 0.01) were independent risk factors for 1 year mortality.
CONCLUSIONS: In elderly patients, malnutrition was a significant additional risk
factor for early death. Nutritional assessment should be included in the routine
preoperative selection. In malnourished patients, nutritional support before and
after operation and a careful postdischarge care might be beneficial, but it
should be corroborated by further prospective studies.