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MMMMMMMMMMMM + MMMMMMM C 1234567890 The Sample Company 000004 ENDORSEMENT_LINE______________ SACKPACK_____________ MR A SAMPLE DESIGNATION (IF ANY) ADD 1 ADD 2 ADD 3 ADD 4 ADD 5 ADD 6 Online Go to www.envisionreports.com/VVUS or scan the QR code  login details are located in the shaded bar below. Votes submitted electronically must be received by 11:59 p.m., EST, on June 4, 2019. Important Notice Regarding the Availability of Proxy Materials for the VIVUS, Inc. Annual Meeting of Stockholders to be Held on June 5, 2019 Under Securities and Exchange Commission rules, you are receiving this notice that the proxy materials for the annual stockholders meeting are available on the Internet. Follow the instructions below to view the materials and vote online or request a copy. The items to be voted on and location of the annual meeting are on the reverse side. Your vote is important! This communication presents only an overview of the more complete proxy materials that are available to you on the Internet. We encourage you to access and review all of the important information contained in the proxy materials before voting. The proxy statement and annual report to stockholders are available at: www.envisionreports.com/VVUS Easy Online Access  View your proxy materials and vote. Step 1: Step 2: Step 3: Step 4: Step 5: Go to www.envisionreports.com/VVUS . Click on Cast Your Vote or Request Materials. Follow the instructions on the screen to log in. Make your selections as instructed on each screen for your delivery preferences. Vote your shares. When you go online, you can also help the environment by consenting to receive electronic delivery of future materials. Obtaining a Copy of the Proxy Materials  If you want to receive a copy of the proxy materials, you must request one. There is no charge to you for requesting a copy. Please make your request as instructed on the reverse side on or before May 24, 2019 to facilitate timely delivery. + 2 N O T C O Y 031O3C MMMMMMMMM Stockholder Meeting Notice 1234 5678 9012 345

VIVUS, Inc.s Annual Meeting of Stockholders will be held on Wednesday, June 5, 2019 at the offices of Weil, Gotshal & Manges LLP, 767 Fifth Avenue, New York, New York 10153, at 8:00 a.m., local time. Proposals to be voted on at the meeting are listed below along with the Board of Directors recommendations. Proposals  The Board of Directors recommends a vote FOR all of the nominees listed and FOR Proposals 2, 3, 4 and 5. 1. Election of Directors: 01 - John P. Amos 02 - Karen Ferrell 03 - Edward A. Kangas 04 - Thomas B. King 05 - David Y. Norton 06 - Jorge Plutzky, M.D. 07 - Eric W. Roberts 08 - Herman Rosenman 09 - Allan L. Shaw To approve, on a non-binding advisory basis, the compensation of our named executive officers. To ratify the appointment of OUM & Co. LLP as our independent registered public accounting firm for the fiscal year ending December 31, 2019. To approve an amendment to the 2018 Equity Incentive Plan to increase the number of shares of Common Stock reserved for issuance thereunder by 600,000 shares. To approve an amendment to the 1994 Employee Stock Purchase Plan to increase the number of shares of Common Stock reserved for issuance thereunder by 400,000 shares. To transact such other business as may properly come before the meeting or any adjournment or postponement thereof. 2. 3. 4. 5. 6. PLEASE NOTE  YOU CANNOT VOTE BY RETURNING THIS NOTICE. To vote your shares you must go online or request a paper copy of the proxy materials to receive a proxy card. If you wish to attend and vote at the meeting, please bring this notice with you. Heres how to order a copy of the proxy materials and select delivery preferences: Current and future delivery requests can be submitted using the options below. If you request an email copy, you will receive an email with a link to the current meeting materials. PLEASE NOTE: You must use the number in the shaded bar on the reverse side when requesting a copy of the proxy materials.    Internet  Go to www.envisionreports.com/VVUS. Click Cast Your Vote or Request Materials. Phone  Call us free of charge at 1-866-641-4276. Email  Send an email to investorvote@computershare.com with Proxy Materials VIVUS, Inc. in the subject line. Include your full name and address, plus the number located in the shaded bar on the reverse side, and state that you want a paper copy of the meeting materials. To facilitate timely delivery, all requests for a paper copy of proxy materials must be received by May 24, 2019. Stockholder Meeting Notice