The maintenance dosage of certolizumab pegol for adults is 200 mg every 2 weeks. A dosage of 400 mg every 2 weeks can be considered when there is an insufficient response.

Available data in adults with plaque psoriasis suggest that there is usually a clinical response within 16 weeks of treatment. Continued treatment should be carefully reconsidered in people whose psoriasis shows no evidence of therapeutic benefit within the first 16 weeks of treatment. Sometimes, when there is an initial partial response, it may subsequently improve with continued treatment beyond 16 weeks.