Background of Ghrelin / GHRL antibody

This gene encodes ghrelin-obestatin preproprotein, which generates ghrelin and obestatin. Ghrelin is an endogenous ligand for the growth hormone secretagogue receptor and is involved in regulating growth hormone release. Obestatin was initially reported to be an endogenous ligand for the orphan G protein-coupled receptor GPR39 and was involved in satiety and decreased food intake; however, these findings are controversial. Recent reports show that obestatin is involved in inhibiting thirst and anxiety, improving memory, regulating sleep, affecting cell proliferation, and increasing the secretion of pancreatic juice enzymes. Alternative promoters and alternative splicing result in multiple transcript variants, some of which encode different protein isoforms and some of which do not encode a protein but may regulate the ghrelin-obestatin preproprotein expression. In addition, antisense transcripts for this gene have been identified and may also function in regulation of the ghrelin-obestatin preproprotein expression. [provided by RefSeq]. Transcript Variant: This variant (1) is generated from an alternate promoter and has a shorter 5' UTR. It encodes the longest isoform (1), which includes both the ghrelin and obestatin ligands. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

GTX78202 in Sandwich ELISA for analysis of active ghrelin. Chicken anti-ghrelin C-terminal peptide (GTX78203) was coated on ELISA plate. Various concentrations of active ghrelin were incubated and detected with biotinylated GTX78202 at a 1:1000 dilution

GTX78203 in Sandwich ELISA for analysis of active ghrelin. The antibody was coated on ELISA plate. Various concentrations of active ghrelin were incubated and detected with GTX78202 at a 1:1000 dilution.