Genome-scale studies of DNA damage and mutations

Nicolas Luscombe, from The Francis Crick Institute in London, UK, studies how the biology of an organism is shaped by regulation of gene expression. His research group investigates this at various levels of complexity, from single-celled bacteria and yeast to complex mammals. They study the regulatory mechanism operating at transcription, and transcription factors (TF) represent the major focus of their research. They investigate how TF regulate gene transcription, the mechanisms by which themselves are regulated, and the interactions of these factors with other cellular processes, such as metabolism. He has been invited by CRG PhD Students.