George trained as a tax accountant and, while in her twenties, helped to found an accountancy business in Chapel-en-le-Frith. She has lived in the High Peak area for over 25 years, is married with four children and lives in Tunstead Milton near the centre of the constituency.[7][5]

She has been a school governor in Whaley Bridge, and is a committee member for the Whaley Bridge After School Club. She has been involved in local campaigns in the High Peak area; including setting up a pension scheme for the after-school club, and setting up a neighbourhood plan as Vice Chair of Chapel Vision.[8]

Before becoming an MP, George worked at the Central Office of the Union of Shop, Distributive and Allied Workers (USDAW) in Manchester,[9] where she was the parliamentary officer for eighteen years,[10] campaigning on behalf of staff in retail, most notably campaigning on wages and maternity/paternity leave and setting up the ‘Freedom from Fear’ campaign which addresses violence and abuse of staff in shops. Her work as political/parliamentary officer for USDAW involved liaising with parliamentary MPs, and organising USDAW members to contact their MPs on relevant issues,[11] including the campaign opposing a proposal to liberalise Sunday trading, which was defeated by a majority of 31 votes, including 27 Conservative MPs[12] and campaigning against the Trade Union Act which was passed in 2016.[13]

In the vote of January 2019, George voted against Theresa May's Brexit deal.[14] She also voted for Labour's amendment for Parliament to vote on options which prevent the UK leaving the EU without a deal, including a permanent customs union and a referendum, for Tory MP Dominic Grieve's amendment to force the government to make time for six days of debate on Brexit alternatives before 26 March, for Labour MP Yvette Cooper's amendment to give Parliament time to pass a bill that would postpone Brexit until 31 December if the Prime Minister's deal is not approved by 26 February, for Labour MP Rachel Reeves' amendment for the government to ask the EU to postpone Brexit for an indefinite period, for Tory MP Dame Caroline Spelman's amendment to reject leaving the EU without a deal and against Tory MP Sir Graham Brady's amendment to call for Parliament to require the backstop is replaced with "alternative arrangements to avoid a hard border" with Ireland.

In 2017, a 2016 tweet surfaced from @ruthforhighpeak, reading "I enjoyed Theresa May's LABOUR party speech at #CPC16 today. So much better than Mein Fuhrer Amber Rudd yesterday." George's personal twitter account had stated she also "tweets as @ruthforhighpeak". George assigned responsibility for the tweet to "a very passionate campaign volunteer".[15]

On 19 February, George, who had been asked to comment on a Facebook comment suggesting the The Independent Group's financial backers were "Israelis", replied that "Support from the State of Israel, which supports both Conservative and Labour ‘Friends of Israel’ of which Luciana was chair is possible and I would not condemn those who suggest it, especially when the group’s financial backers are not being revealed". After Jewish groups said that she was indulging an antisemitic conspiracy theory, she apologised and withdrew her comment.[16][17][18]