2.A.1.58.7Unc-93b1 or Unc93b1 of 597 aas and 12 TMSs. Plays
a role in innate and adaptive immunity by regulating
nucleotide-sensing Toll-like receptor (TLR) signaling. Required for the
transport of a subset of TLRs (including TLR3, TLR7 and TLR9) from the
endoplasmic reticulum to endolysosomes where they can engage pathogen
nucleotides and activate signaling cascades. May play a role in
autoreactive B-cells removal (Isnardi et al. 2008). Induces apoptotic cell death and is cleaved by host and viral proteases (Harris and Coyne 2015).