Most were Pd-103, 16% were I-125. 37% had implant only; the remainder had EBRT to prostate + seminal vesicles. Hormones used in 23%.

3-yr potency preservation of 50.5%. The preimplant erectile score was 29 for those with adequate postimplant function and 25 for those without. Median time to ED was 5.4 months. After brachy, erectile score was 20 in potent patients and 3 in those with ED. On multivariate analysis, the preimplant erectile score and D50 to the proximal crura predicted for ED.

Retrospective. 1561 pts. Treated with various techniques including brachy alone, brachy + hormones, or brachy + EBRT. Death from prostate cancer was counted if a pt died with the presence of metastatic disease. Pts who had rising PSA at the time of death or who were receiving systemic treatment at the time of death were not necessarily counted as prostate cancer related deaths.

Conclusions: The PSA bounce does not predict subsequent failure. Caution is advised in interpreting an early increasing PSA level in the first 30 months after 125I brachytherapy in favorable-risk patients.

Conclusions: "Patients experiencing a PSA bounce are more likely to be younger and will have a better bRFS. The PSADT cannot differentiate a PSA bounce from bF. The time to the initial PSA rise after nadir is an excellent discriminator of bF from PSA bounce. The time of the PSA rise after nadir occurs far sooner for a PSA bounce than for bF. This factor should be considered when assessing a patient with a rising PSA level after PI before a patient is administered salvage therapy."

The use of PSA bounce definitions other than 0.2 did not provide additional prognostic benefit. Patients with PSA bounce had superior bRFS rates to those without PSA bounce. The time to first rise in PSA is an important discriminator between a PSA bounce and bF; a bounce usually occurs much earlier than a rise that corresponds to bF.

Conclusion: A bounce definition of a rise ≥0.2 ng/mL is a reliable definition among several other definitions. The time to first PSA rise is the most valuable factor for distinguishing between a bounce and biochemical failure.