"Although several medications and supplements do interact with lisinopril, it is not among the drugs that have a well-known interaction with grapefruit juice and other grapefruit products."

Medications That React With Grapefruit

Although lisinopril is not among them, several medications do interact with grapefruit, including some used to treat high blood pressure. You should not eat or drink grapefruit-containing products if you take medications classified as calcium-channel blockers to treat hypertension, Mayo Clinic advises. Calcium-channel blockers include nimodipine, nisoldipine and nifedipine. Other drugs that can interact with grapefruit include the antidepressant sertaline; the antihistamine fexofenadine; the anti-arrhythmia drug amiodarone; the anti-anxiety drug buspirone; the immunosuppressants cyclosporine, sirolimus and tacrolimus; the statins atorvastatin, lovastatin and simvastatin; the anti-seizure drug carbamazepine; and the anti-retroviral medications indinavir and saquinavir.