Acceptability and Effectiveness of Colonography Compared to Colonoscopy for the Detection of Advanced Adenomas in Patients at High Risk for Colorectal Cancer

Trial Information

Acceptability and Effectiveness of Colonography Compared to Colonoscopy for the Detection of Advanced Adenomas in Patients at High Risk for Colorectal Cancer

Secondary objective: to evaluate the medical and economic impact of the implementation of
CT- colonography in this setting.Methodology: prospective multicenter randomized controlled
trial with direct patient benefitN° of patients to be included: 600 Study follow-up :1
consultation and 3 phone contacts (M1, M6 and M12)Evaluation criteria:Main endpoint:
acceptability of the colorectal cancer screening (% of enrolled patients having actually
undergone the exploration)Secondary endpoints: - cost/effectiveness ratio of the 2
diagnostic tests with calculation of the economic and medical costs. - number of advanced
adenoma detected in each group- number of CRC cases detected in each group

Inclusion Criteria:

Surveillance of patients with a personal history of advanced adenoma or CRC:

- Informed consent obtained

- Age ≥ 18 and ≤ 80 years old

- History of advanced adenomatous polyps

- Or history of non metastatic CRC with curative surgery and without other treatment
more than 2 years before enrollment.

- Previous medical examination

Screening of patients with a Family history of CRC at high risk:

- Informed consent obtained

- Age ≥ 18 and ≤ 80 years old

- First degree family history of colorectal cancer diagnosed <60yrs during the five
previous years-Previous medical examination

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