Cushing’s syndrome A disorder characterized by obesity due to hypersecretion of GCs. Causes:- Due to excessive secretion of GCs. Particularly due to oversecretion of cortisol If it is due to pituitary origincushing’s Di If it is due to adrenal origin cushing’s Sy

Addison’s disease Causes:- failure of a.cortex to secrete corticosteroids occurs due to the following: 1. atrophy of A.cortex due to autoimmune diseases 2. destruction of the gland during TB 3. destruction of hormone secreting cells in A.cortex by malignant tissues. 4. congenital failure to secrete cortisol 5. failure of anterior pituitary 6. lesion in area of hypathalamus where corticotropin releasing hormone is produced.

Signs and symptoms Pigmentation of skin & mucus membrane Muscular weakness Hypotension Hypoglycemia Nausea, vomitting & diarrhea (if prolonged leads to dehydration & loss of body wt.) Susceptibility to any type of infection and Inability to withstand any stress ↓cardiac output and decreased workload of the heart leading to decrease in the size of heart.

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