As many of us have the tendency to put on weight, there are certain scenarios when a person may lose weight quite unintentionally. Depressed people are those who feel a lingering emptiness inside themselves and they egg this feeling on until it takes over their entire life. It is generally seen and heard that people who are suffering from depression have the propensity to binge eat and hence put on weight.
Anorexia Nervosa is an eating disorder where the fear of putting on weight is predominant and the need and yearning of losing weight surpasses everything. In Type 1 diabetes, which is also known as insulin dependent diabetes, the pancreas stops the production of insulin in the body, causing a deficiency. Due to this reason, the body is unable to process the calorie intake through fats and carbohydrates. There are many who suffer from constipation and are not able to relieve themselves properly every morning. The body secretes the thyroid hormone which helps generate energy and regulate weight and body temperature. The reason behind is that when too much thyroid is produced in the body, there is excess energy created and in the process of burning the energy, the person burns a lot of calories, which in turn results in involuntary weight loss. Researchers have investigated the association between energy expenditure and alcohol consumption and reported that alcoholics have higher resting metabolic rates compared to non-alcoholics. In this study the authors were careful to measure resting metabolic rate two hours postprandially rather than in the fasting state, in order to nullify the effects of the activating energy required for the gluconeogenic and ketogenic pathways. The advice to avoid alcohol in those wishing to lose weight is based on the ‘eat-too-much, do-too-little’ energy balance theory of weight gain.
Biochemically, MEOS seems to involve a loss of energy and there appears to be no coupling of the pathway to the production of ATP.
Weight Gain and Antidepressants (Including SSRIs)Yeah Prozac do cause weight gain to most people. In order to keep off the weight in the future, you may have to make some lifestyle changes to stay slim. This accelerates your body’s metabolism levels dramatically thereby resulting in sudden weight loss, sweating and irritability. But on the contrary, unexplained weight loss is actually researched to be an early sign of diabetes. It can be due to heartbreak, familial issues, professional setbacks or a recurring illness. When a person is suffering from anorexia, she either starts to weigh every single portion of food that would be eaten or vomits out food after every meal along with using purgatives to lose weight. Insulin is essential for the proper functioning of the body as it allows glucose to fuel the cells. At the same time, diabetics have a low body glucose level as they pass glucose through their urine.
It hampers the body’s capability to absorb essential nutrients like carbohydrates and does not retain fat anymore. For while there is an association between alcohol intake and body weight, it is problematic trying to ascribe cause and effect in this relationship. For example in a study published in the American Journal of Clinical Nutrition2, researchers measured the resting energy expenditure of alcoholics with fatty liver disease, alcoholics without fatty liver disease and normal healthy subjects using indirect calorimetry. This allowed the authors to state more definitively that alcoholics have higher resting metabolic rates compared to non-alcoholics, and fatty liver disease attenuates this association. This theory assumes that ethanol provides its 7.1 kcal per gram of energy and that if this is not burnt up through exercise, it will be stored as fat. This may be because unlike normal oxidation of ethanol in the mitochondria, MEOS in the endoplasmic reticulum produces NADPH (rather than NADH) which is not available for electron transport and energy production.

Potentially, alcohol causes weight loss because the microsomal ethanol oxidising system allows the inefficient use of ethanol to produce heat, rather than ATP. There are diet pills that cause the body not to metabolize all the food you eat, so it’s passed out of your system and not stored as fat.
Lack of appetite and even the thought of downing food can create a very unpleasant experience.
However, there are anti-thyroid medications that help in bringing down the pace of thyroid hormone production. This is because there is increased urination and when glucose levels increase, muscle mass begins to shrink.
So, when exposed to gluten, the body generates an immune response in the small intestine in such people. Unintentional weight loss is not healthy and can be attributed to various physical and mental conditions. This is seen in the case of manic depression, when an individual loses interest in food and the pleasures that one derives out of it and usually leads to malnutrition. It is a way of starving oneself to look perfect, when in reality anorexia distorts the body image.
These are the reasons why people with diabetes tend to lose weight drastically, even though their appetite might not get affected at all.
The main effect of purgatives is that they help empty out the bowels by increasing bowel movements, which can hold up to 2–10 pounds of feces and losing that from your body means losing the same mass from your overall weight.
So, they will be seen eating more than a regular person of the same body mass, but will either fail to put on weight or keep losing weight. In addition confounding variables interfere with the relationship and further muddy the picture. The results showed that alcoholics without fatty liver disease had significantly higher resting energy expenditures compared to normal healthy subjects and alcoholics with fatty liver disease.
This supports the hypothesis that the hepatic endoplasmic reticulum MEOS might be responsible for the increased energy in those who consume alcohol regularly, because liver damage may reduce this effect somewhat. However, this calorie counting obsession that pervades the mainstream medical establishment is erroneous because it assumes that calories are used efficiently in humans. As a result MEOS dissipates the energy produced from the oxidation of ethanol as heat (figure 1)4. In the microsome, the NADP molecule (red) replaces the NAD molecule (black) found in the mitochondria. Maybe you’re simply searching for the right information to help you lose and keep the weight off.
Maybe one of your diet buddies has decided to buy diet pills, or maybe you’ve seen or heard a commercial for diet supplements promising easy fast weight loss. Although, you needn’t press the panic button, make sure you determine the causes to avoid any potential problems.
Counseling, constant expert intervention and anti-depressants help in combating the problems of depression and associated weight loss. Medications to control your insulin levels and early detection are some of the ways in which you can keep both the disease and weight loss at bay. In a course of time, inflammation and potential damages occur in the small intestine lining that causes deficiency in nutrient absorption. However, that being said, evidence in the literature does suggest that alcohol causes weight loss because the ethanol component of alcoholic drinks may alter metabolic flux to increase resting metabolic rate (RMR). The VO2 and VCO2 was also significantly higher in the alcoholics with normal livers, compared to the other two groups.
Upregulation of MEOS has been reported mostly in animal experiments, but human studies confirm that the effects are real and relevant to human subjects.

That ethanol and other dietary factors might be metabolised inefficiently is never considered. Animal studies have shown that MEOS might not be limited to hepatocytes, but also be involved in the metabolism of drugs in adipocytes. This causes the energy derived from oxidation to be dissipated as heat rather than producing ATP through mitochondrial transport. So you may ask, how does the diet pills work to cause weight loss, while I continue to eat the same amount? Ethanol contains 7.1 kcal per gram which is more than both carbohydrate and fat, and yet when ethanol is consumed along with a mixed diet, weight loss occurs1.
However, when the authors used the traditional Harris-Benedict equation (body mass index multiplied by a factor to take into account physical activity) they found no difference between the groups, suggesting that traditional textbook measures of energy expenditure are not accurate regarding alcohol metabolism. Because around 25 % of the resting energy expenditure of humans is accounted for by the metabolic function of the liver, it is not unreasonable to assume that a small increase in MEOS flux could have a considerable effect on the total energy expenditure and oxygen consumption of the body. The calorie is a calorie brigade do not fully understand, or conveniently forget to suit their agenda, that human metabolism is far more complicated than subtracting the energy used in physical activity from the energy ingested in food.
Human studies show that increasing ethanol consumption to 2000 kcal per day only increases weight gain by 6 grams per day, but similar increases in chocolate intake cause weight gain of 198 grams per day4. Even the most natural-sounding diet pills or weight loss supplements can be useless for weight loss, or dangerous, or both.
Since, there is no definite cure for Celiac Disease; following a strict gluten free regimen is important to manage the symptoms. It is suggested that the activation of wasteful metabolising pathways such as the microsomal ethanol oxidising system (MEOS) located in the hepatic endoplasmic reticulum is responsible for this effect. The presence of MEOS is a fascinating prospect because not only does it demolish the textbook energy balance fallacy, it also invites speculation as to how nutrition might affect the MEOS systems. In this case the extra weight is unlikely to be explained by diuresis because chronic alcohol intake causes net fluid retention. Diet pills are very tempting things if you want to lose weight, especially if you have tried several conventional weight loss plans without success. There are almost as many weight loss methods and diet pills available as there are people who want to lose weight. If alcohol causes weight loss through activation of MEOS, dietary intake may further modify this effect. Examination of fecal matter also shows that the extra weight is not accounted for by excretion. The side effects and dangers of some diet and weight loss pills can vary enormously because many of these pills contain a cocktail of ingredients and because dosage instructions may be inadequate. In addition, oxidation of ethanol in this way is not linked to the conservation of energy, as might be expected from other oxidation pathways. One common mistake many people make as they diet is the fact they don’t really understand how much is provided by the food they are eating. Possible side effects include: nervousness, tremor, diarrhea, bulging eyes, racing heartbeat, elevated blood pressure even heart failure. It’s important as you begin your weight loss to understand and come to grips with the cause of your weight.