Data show that miR-181c was inversely correlated with the levels of ST8SIA4 expression in chronic myelocytic leukemia (CML) cell lines and samples.

This is the first report to demonstrate a role for a glycosyltransferase (zeige GTDC2 Antikörper) in human pluripotent stem cell lineage specification.

changes in the glycosylation patterns and sialylation levels may be useful markers of the progression of breast cancer, as well as miR (zeige MLXIP Antikörper)-26a/26b may be widely involved in the regulation of sialylation machinery by targeting ST8SIA4.

The polybasic region of the polysialyltransferaseST8Sia-IV binds directly to NCAM (zeige NCAM1 Antikörper).

Sequence Requirements for Neuropilin-2 (zeige NRP2 Antikörper) Recognition by ST8SiaIV and Polysialylation of Its O-Glycans.

Mice deficient for ST8SiaIV have impaired long-term spatial memory in two tasks that critically rely on the hippocampus.

Results demonstrate that the early development of calbindin (zeige CALB1 Antikörper)-positive periglomerular interneurons depends on the presentation of polysialic acid on NCAM (zeige NCAM1 Antikörper) and requires the activity of both St8sia2 (zeige ST8SIA2 Antikörper) and St8sia4

ST8SiaIV synthesized polySia selectively on a NRP2 (zeige NRP2 Antikörper) glycoform that was characterized by the presence of sialylated core 1 and core 2 O-glycans.

Results indicate that the polySTs ST8SiaII (zeige ST8SIA2 Antikörper) and ST8SiaIV not only recognize an acidic patch in the FN1 (zeige FN1 Antikörper) domain of NCAM (zeige NCAM1 Antikörper) but also must contact sequences in the Ig5 domain for polysialylation of Ig5 N-glycans to occur.

the negative and positive effects of ST8SiaIV overexpression observed during peripheral nerve regeneration suggest that an optimized time- and differentiation-dependent control of expression in Schwann cells may further improve nerve regeneration

While both ST8SiaII (zeige ST8SIA2 Antikörper) and ST8SiaIV mRNA levels decrease around the time of eye opening in mouse visual cortex, only ST8SiaII (zeige ST8SIA2 Antikörper) mRNA level reduction is regulated by sensory experience

ST8Sia4 knockout mice display a decreased motivation in social interaction. This deficit can be partly explained by olfactory deficits and was associated with a clear decrease in PSA (zeige NPEPPS Antikörper)-NCAM (zeige NCAM1 Antikörper) expression in all brain regions analyzed.

This study demonistrated that mice lacking St8siaIVpolysialyltransferase have an accelerated onset of remyelination after cuprizone-induced demyelination.

Protein Überblick

The protein encoded by this gene catalyzes the polycondensation of alpha-2,8-linked sialic acid required for the synthesis of polysialic acid, a modulator of the adhesive properties of neural cell adhesion molecule (NCAM1). The encoded protein, which is a member of glycosyltransferase family 29, is a type II membrane protein that may be present in the Golgi apparatus. Two transcript variants encoding different isoforms have been found for this gene.