This study is only collecting specimens from current patients of PENN Fertility Care.

The purpose of this investigation is to assess if markers of oxidative stress that are known to be associated with other medical conditions can be detected in women undergoing infertility treatment and normal women of similar age. Oxidative stress may affect a woman's eggs or the follicular cells that surround and nurture them. Other markers of to be investigated include markers of cellular aging and DNA structural changes.

Presence of these markers will be compared in blood and urine samples taken during infertility treatment, and follicular fluid at the time of IVF (if applicable).

Women undergoing In vitro fertilization at the University of Pennsylvania

Criteria

Inclusion Criteria:

Women aged 18-50

Infertility patients only:

Women undergoing infertility treatment (with or without in-vitro fertilization) at the University of Pennsylvania's PENN Fertility Care

Verified infertility diagnosis of any of the following:

Endometriosis (minimal or mild)

Endometriosis (moderate or severe)

Tubal factor

Hypogonadotrophic hypogonadism

Polycystic ovary syndrome

Diminished ovarian reserve

Male factor

Unexplained

Healthy normal volunteers only:

Not undergoing infertility treatment

Not using hormonal contraception

Exclusion Criteria:

Currently pregnant or breastfeeding

Post-menopausal

Concurrent participation in investigational trial

Other health problems which, in the opinion of the investigator, may affect participation

Contacts and Locations

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study.
To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below.
For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00194220