Cholinesterase Inhibitors Drug Class

Cholinesterase inhibitors might create minimal improvements in the overall ability to function and memory. The inhibitor affects the central nervous system and penetrates the blood-brain wall and allows cholinergic transmission within the brain. Cholinergic transmission includes the neurotransmitter being produced from the nerve fibers, requisite to designated receptors on additional cholinergic nerve fibers and distributing the message to create a response. Cholinesterase enzymes exist within the synaptic cleft of the cholinergic synapses, and they are responsible for hydrolyzing the acetylcholine, thus decreasing its concentration within the synapses. Cholinesterase inhibitors merge with the cholinesterase leading to an accelerated acetylcholine in the synapses. This causes an increase in parasympathetic action. For instance, it might aid constriction of pupils within the eyes, vasodilatation, accelerated secretion of saliva, sweat and tears, slow heart pulse, constriction of the bronchioles or secretion of mucus within the breathing tract.

Cholinesterase Inhibitors Drugs

Cholinesterase Inhibitors Uses

Cholinesterase inhibitors are mostly used in the treatment of symptoms of Alzheimer’s disease. They can also be used to treat other dementia types like multi-infarct dementia and dementia with Lewy bodies.

Medical researchers believe that minimizing issues related to loss of memory might help an individual with Alzheimer’s disease to live a much better life. In some instances, minimizing these issues might help persons to live a more independent life for a longer duration of time.

Cholinesterase Inhibitors Side Effects

Like any other drug, Cholinesterase inhibitors come with their own collection of side effects. Below you will find a list of common side effects. Note that not all side effects are listed. If you find yourself suffering from severe side effects, contact your doctor.

Common side effects include:

Prolonged muscle contraction due to actions on the neuromuscular junction

Cholinesterase Inhibitors Interactions

Like any other drug, cholinesterase inhibitors interact with other drugs and medications. Below you will find drugs that may interact with cholinesterase inhibitors. Note that this list is not complete.

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