A 46-year-old man gave a history of progressive loss of vision starting 8 months earlier. Two months before admission he also noticed headache that has been increasing in intensity since then. He was first seen by an ophthalmologist who prescribed eyeglasses assuming that his problem was nothing but a defective vision. As both problems persisted, even after eyeglasses wearing for some time, he decided to come to Belo Horizonte, MG, Brazil seeking a second opinion. The second oculist, examining the retina with an ophthalmoscope, described the presence of bilateral edema of papilla and sent the patient to a neurologist, who, except for the alterations on the papilla, found no signs of neurological involvement. Magnetic resonance imaging of the brain though showed a huge loculated tumoral mass in the occipital area (Figure A). He was submitted to neurological surgery with the diagnosis of glioblastoma multiforme. A piece of the tumor examined during surgery confirmed the diagnosis of paracoccidioidomycosis of the brain (Figure B: note the fungus _ "wheel's ship (mickey mouse) shape" _ red arrow). During operation the tumor was excised completely with a safety margin. The patient recovered in two weeks without sequela. A chest x-ray taken on the course of hospitalization showed a discrete bilateral pulmonary intersticial consolidation, and the computerized tomography disclosed bilateral lung alterations which suggested pulmonary involvement by the fungus (Figure C). The patient has been treated with trimethoprim-sulfamethoxazole for 2 years now and during his follow up, every six months, has been feeling well.