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With the human genome sequence in the bag, a biologist at the University of California, San Diego, is calling for a project to map the genome of our closest relative—the chimpanzee. Ajit Varki points out that a chimp genome project could steam ahead because chimps share 99 per cent of our DNA, and our completed sequence could be used as a guide (Genome Research, vol 10, p 1065). Varki believes that understanding the small genetic differences that help chimps resist diseases such as AIDS,