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Dr. Paylor is a leader in developing and implementing behavioral test batteries for the analysis of mutant mice. In particular, he is well recognized for his research directed towards the behavioral characterization of mouse genetic models of neurodevelopmental disorders including Fragile X, Williams-Beuren, Rett, DiGeorge, and Smith-Magenis syndromes. New findings from his lab have shown that both pharmacological and genetic manipulations can alter several behavioral responses in the mouse model of Fragile X. Dr. Paylor has also identified a novel transgenic mouse model with unique molecular alterations resulting in multiple autistic-like traits. Recently, Dr. Paylor’s lab has initiated a project with the long-term goal to employ the R6/2 transgenic mice to identify putative genetic/molecular modifiers of Huntington’s Disease, which could lead to potential targets for therapeutic intervention.

Mouse genetic models of autism-related traits : how do we know when we have one? [electronic resource] / Richard E. Paylor.

Series:

NIH neuroscience series

Author:

Paylor, Richard E. National Institutes of Health (U.S.)

Publisher:

Other Title(s):

NIH neuroscience series

Abstract:

(CIT): Dr. Paylor is a leader in developing and implementing behavioral test batteries for the analysis of mutant mice. In particular, he is well recognized for his research directed towards the behavioral characterization of mouse genetic models of neurodevelopmental disorders including Fragile X, Williams-Beuren, Rett, DiGeorge, and Smith-Magenis syndromes. New findings from his lab have shown that both pharmacological and genetic manipulations can alter several behavioral responses in the mouse model of Fragile X. Dr. Paylor has also identified a novel transgenic mouse model with unique molecular alterations resulting in multiple autistic-like traits. Recently, Dr. Paylor"s lab has initiated a project with the long-term goal to employ the R6/2 transgenic mice to identify putative genetic/molecular modifiers of Huntington"s Disease, which could lead to potential targets for therapeutic intervention.