The antimicrobials activities of crude and diluted honey were determined against four clinical isolates from surface and deep wounds. Staphylococcus aureus, Pseudomonas aeruginosa, Klebsiella pneumoniae and Escherichia coli were isolated from wounds by routine microbiological methods. Kirby- Bauer’s disc diffusion method was employed in determining the susceptibility of bacterial isolates to different concentrations of honey. The results from the zone of inhibition obtained (in mm) showed that the growth of all isolates was completely inhibited by 20-100% honey concentrations. The minimum inhibitory concentrations (MIC) of honey for P. aeruginosa and S. aureus were at 10 % (v/v) while that of E.coli and K. pneumoniae were 20% (v/v). The degree of susceptibility of the wound isolates to honey was compared with that of ten commercially available antibiotic discs. The result obtained revealed that the susceptibility pattern of honey at 40% (v/v) compared favourably and better than amoxicillin, streptomycin, ceftriazone and erythromycin.