Bottom Line:
There was a comparable, highly significant decrease in TMI with amlodipine and atorvastatin, but no additional benefit for the combination.Adverse events were comparable among groups.Atorvastatin was as potent an anti-ischaemic agent as amlodipine.

Mentions:
At Week 26, the median number of ischaemic episodes in all three groups decreased significantly (P < 0.001, within-treatment comparison) (Figure 3). There was no significant difference among the three treatment groups in the change from baseline to Week 26 in the number of ischaemic episodes (overall P = 0.922). Transient myocardial ischaemia episodes decreased by >66% in all cohorts, with >50% of patients becoming TMI-free at the final visit in all three groups (Figure 3). Additionally, the median duration of the TMI episodes decreased by >75% in all three groups. There were no differences in efficacy between the treatments, with virtual elimination of ischaemic events by Week 18; atorvastatin was as effective as amlodipine (Figure 3).

Mentions:
At Week 26, the median number of ischaemic episodes in all three groups decreased significantly (P < 0.001, within-treatment comparison) (Figure 3). There was no significant difference among the three treatment groups in the change from baseline to Week 26 in the number of ischaemic episodes (overall P = 0.922). Transient myocardial ischaemia episodes decreased by >66% in all cohorts, with >50% of patients becoming TMI-free at the final visit in all three groups (Figure 3). Additionally, the median duration of the TMI episodes decreased by >75% in all three groups. There were no differences in efficacy between the treatments, with virtual elimination of ischaemic events by Week 18; atorvastatin was as effective as amlodipine (Figure 3).

Bottom Line:
There was a comparable, highly significant decrease in TMI with amlodipine and atorvastatin, but no additional benefit for the combination.Adverse events were comparable among groups.Atorvastatin was as potent an anti-ischaemic agent as amlodipine.