Is This the Beginning of the End for Donald Trump?

On Friday, Donald Trump’s presidential campaign suffered a major blow after a recording from 2005, in which Trump and Access Hollywood host Billy Bush engaged in a lewd conversation about women, went viral. Since then, a slew of Republican leaders, most notably Senator John McCain, have withdrawn their support of the candidate and have pledged to write in a protest vote against him. “Donald Trump’s behavior this week, concluding with the disclosure of his demeaning comments about women and his boasts about sexual assaults, make it impossible to continue to offer even conditional support for his candidacy,” McCain said in a statement on Saturday, while others beggedTrump to drop out and let Pence lead the ticket instead.

After a particularly contentious debate on Sunday night, many pundits hoped Trump’s better-than-expected performance could stop the massive exodus of Republican support for him. But on Monday morning, news broke that Speaker of the House Paul Ryan had also backed away from thetha candidate.

During a conference call with House Republicans, Ryan said he could no longer defend Trump and will instead be focusing his time on keeping the Republican majority in Congress, perhaps all but admitting that he believes Trump will lose the election. His spokeswoman later confirmed to TheNew York Times that while Ryan had not formally pulled his endorsement, “the speaker is going to spend the next month focused entirely on protecting our congressional majorities,” effectively breaking away from his party’s candidate.

During the weekend, there were several rumors that Trump’s vice Presidential pick Mike Pence wanted off the ticket, and that his campaign manager Kellyanne Conway was also considering resigning. In a post-debate interview, Conway even hinted she might possibly quit after answering one of Chris Matthews’s questions with a strangely vague response. “I’m with the campaign until the bitter end, unless . . . .” When asked to clarify by Matthews what she meant, Conway refused to elaborate. Pence has since restated he is standing by Trump until November 8, as has Conway.

But Ryan’s recent declaration may signal he has finally reached his own “unless . . . ” breaking point. With the election only 28 days away, losing the most prominent national Republican leader is certainly a major strike to Trump’s campaign. Could this finally be the beginning of the end of his candidacy?