After many losing seasons as a workhorse starting pitcher with poor teams, he was acquired by the New York Yankees late in the 1964 season to serve as their closer. He saved 8 games in 13 appearances as the Yankees were locked in a tight pennant race in September 1964, but was ineligible for the World Series, having been acquired after September 1st. He compiled 19 saves for the Yankees in 1965, and 13 in 1966, but the team was headed downwards at that point and Ramos never got another chance to pitch in the post-season. After being cut by the Los Angeles Dodgers during spring training, he played his final major league games with the new Washington Senators in 1970.