This gene encodes a member of the neurotrophic tyrosine receptor kise (NTRK) family. This kise is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Siglling through this kise leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alterte transcriptiol splice variants encoding different isoforms have been found for this gene