Rabbit Polyclonal| Catalog number: 10956-1-AP

Featured ProductKD/KO validated

Proteintech sets the benchmark for antibody validation.
Either we internally have validated the specificity of this antibody using siRNA KD
and/or there are published KD/KO data for this antibody (see Publications tab)

Background

Fis1 (fission 1) is an integral mitochondrial outer membrane protein that participates in mitochondrial fission by interacting with dynamin-related protein 1 (Drp1). Excessive mitochondrial fission is associated with the pathology of a number of neurodegenerative or neurodevelopmental diseases. Increased expression of Fis1 has been found in Huntington’s disease (HD)-affected brain, Alzheimer’s disease (AD) patients, and autism spectrum disorder. This antibody was raised against the full-length of human Fis1 protein, and recognizes endogenous Fis1 protein in various lysates. (21257639, 21459773, 23333625)