Pancreatic beta cells are extremely vulnerable to the destruction of Reactive Oxygen Species (ROS). In both type 1 and type 2 diabetes ROS are involved in the loss of U+000DF-cells. We hypothesized that the deficiency in ROS detoxifying system of...

Diabetic cardiomyopathy (DCM) is a common complication leading to accelerated cardiovascular failure in diabetic patients. Even though the exact mechanism(s) behind this disease still remain unclear, research from several laboratories including our...

This dissertation is a hypothesis-driven research oriented study to determine the role of the pituitary-tumor transforming gene (PTTG) in ovarian cancer, specifically if it is involved in neoplastic transformation leading to tumorigenesis through...

Pancreatic beta cells are extremely vulnerable to destruction by Reactive Oxygen Species (ROS). In type 1 diabetes and islet transplantation ROS are thought to be involved in the loss of beta cells. To test the role of antioxidant in islet...

The effective utilization of CO2 as a renewable raw material for the production of useful chemicals is an area of great interest. There are several motivations for producing chemicals from CO2 whenever possible: (1) CO2 is a cheap, non-toxic and...

Oxygen is critical to aerobic metabolism, but hyperoxia is cytostatic and cytocidal. The precise mechanisms involved in hyperoxic cell injury remain incompletely understood although there is substantial support for the possibility that hyperoxia...

Pancreatic islet transplantation is a very promising treatment for type I diabetes. Many clinical trials have failed due to early islet loss and immune rejection. Reactive oxygen species (ROS) have been demonstrated to be involved in graft damage...

The separation of C02 from light gases is a very important environmental and energy issue. The state-of-the-art process for the purification of C02 uses amine adsorption, which is a complex, and costly. Membrane technology is far less expensive...

Background: Although matrix metalloproteinase (MMPs) and tissue inhibitor of metalloproteinase (TIMPs) play a vital role in tumor angiogenesis and TIMP-3 causes apoptosis, their role in cardiac angiogenesis is unknown. Interestingly, a disruption...

We formulate an integro-difference model to predict the growth and spatial
spread of a perennial plant population with an age-structured seed bank. We allow
the seeds in the bank to be of any age, producing an infinite system of equations.
The...

Research has confirmed that individuals with blindness have an increased risk of
developing sleep problems; this is especially problematic for families with young
children who are blind. Not only does the lack of sleep impact the growth...

Remote terminal units (RTUs) are perimeter supervisory control and data acquisition (SCADA) devices that measure and control actual physical devices. Cyber security was largely ignored in SCADA for many years, and the cyber security issues that now...

Exocytosis of intracellular granules is critical for conversion of inactive, circulating neutrophils to fully activated cells. The p38 MAPK pathway plays a central role in neutrophil exocytosis, although its mechanism of action is unknown. We used...

Hypoxia is characterized by an inadequate oxygen supply to the tissues in
proportion to their metabolic needs, and is a primary factor in traumatic CNS
injury, strokes, cardiopulmonary diseases, and obstructive sleep apnea. The
cAMP-dependent...

A wireless sensor network consists of a large number of low-power nodes equipped with wireless radio. For two nodes not in mutual transmission range, message exchanges need to be relayed through a series of intermediate nodes, which is a process...