That's not a one-liner, but I like that one as well. Not only is the kid cute, but so is Amy Poehler!

Another one I always get a kick out of is the stodgy librarian yelling, “HOLY MOLY, THAT'S A LOT OF MILES!” -- Capital One Venture Card library spot. The lovely Jennifer Garner coyly and politely shushes her.

"The primary purpose of a liberal education is to make one's mind a pleasant place in which to spend one's leisure."
- Sydney J. Harris

The series of TV ads for Intuit QuickBooks featuring Danny DeVito has some memorable one-liners, such as:"Where's YOUR belly rubs?"
"You may do corgis, but you don't have to work like a dog."
"Your job isn't doing hard work, it's making HER do hard work...and getting paid for it!"
"Without you we wouldn't have electricity; our hobby would be going to bed early."

"The primary purpose of a liberal education is to make one's mind a pleasant place in which to spend one's leisure."
- Sydney J. Harris