This trial is a comparative study of Opast tablet and Rikalin capsule 75mg and Rikalin capsule 75mg in combination with Opast tablet to evaluate improvement effectiveness of Opast tablet on subjective symptoms and neurologic claudication in patients with lumbar spinal stenosis.

Limaprost 5㎍ tablet and a capsule of Pegabalin-Placebo thrice a day for 8 weeks.

Drug: Limaprost

Other Name: Opast tablet

Drug: Placebo(for Pregabalin)

mimic Pregabalin 75mg capsule

Active Comparator: Pregabalin & Placebo

Pregabalin 75mg capsule and a tablet of Limaprost-Placebo thrice a day for 8 weeks.

Drug: Pregabalin

Other Name: Rikalin capsule 75mg

Drug: Placebo(for Limaprost)

mimic Limaprost tablet

Active Comparator: Limaprost+Pregabalin

Limaprost 5㎍ tablet and Pregabalin 75mg capsule thrice a day for 8 weeks.

Drug: Limaprost

Other Name: Opast tablet

Drug: Pregabalin

Other Name: Rikalin capsule 75mg

Detailed Description:

Subjects who provided written consents voluntarily after receiving a sufficient explanation about this trial will be assigned to one of groups(study group; limaprost, comparative group 1; pregabalin, comparative group 2; limaprost+ pregabalin) by randomization at the rate of 1:1:1.

Subjects will take assigned investigational drugs thrice a day for eight weeks by double-blind and double-dummy methods, and they will visit the site two times at intervals of four weeks.

At each site visit point, the improvement effectiveness will be comparatively evaluated by evaluation of following endpoints;

Patients with a confirmed diagnosis of waist of spinal canal stenosis.

Limb pain caused by waist of spinal canal stenosis index of VAS 3 or more patients.

Subject who has numbness symptom on lower extremity(ies) and intermittent claudication that are due to spinal canal stenosis and fulfills both of following criteria at the same time

When screening visit, a medical examination by interview had the following symptoms in subjects ; In daily life walking, when walked by within 20 minutes on flatland, the subject can feel the symptoms (numbness, pain or tightness on lower extremity(ies), etc.)

Subject who experienced numbness, pain, tightness or other similar symptom(s) on lower extremity within 15 minutes from test start at baseline(D1) evaluation.

At least one month before the start of the study, patients use of steroid drug except lumbar dura mater.

6 month before the start of the study, patients with ischaemic disease in blood vessel, lung or the coronary artery, varicose artery.

Patients with lumbar necrosis in head of femur avascular necrosis, necrotic foot ulcer.

Patients surgery by lumbar fusion and lumbar decompression.

Patients with renal disease or need to hemodialysis.

serum creatinine > 2xUNL

3 month before the start of the study, patients participated in another clinical research.

Patients with difficult understanding spirit incompetence, lack of will or language barrier.

The investigator judged seriously ill patients need surgery patient.

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Please refer to this study by its ClinicalTrials.gov identifier: NCT01888536