The research objective consisted in studying the local factors of protection of an oral cavity on the basis of balance definition between proinflammatory (INf - γ, TNF - α, IL-8) and anti-inflammatory (IL-4) cytokines with the degree of colonization of Candida in patients with chronic generalized parodontitis. On the basis of the results of this study, it has been established that patients with chronic parodontitis who have a mild and moderate severity level of disease, a high degree colonization of periodontal pockets with Candida tropicalis correlates with a substantial increase in proinflammatory cytokines (TNF - α, IL-8), concentration fall of INF - γ and the increase in anti-inflammatory cytokines of IL-4 level.