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C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by C07D451/00 - C07D477/00

C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings

Lorsqu'ils ne sont pas connus, les produits de formule (III) peuvent être préparés en utilisant le schéma suivant : When they are not known, the products of formula (III) may be prepared using the following scheme:

groups
in which R₄ and R₅, identical or different, represent a phenyl group or a phenyl group substituted by a halogen atom, an alkyl radical containing 1 to 3 carbon atoms, an alkoxy radical containing 1 to 3 carbon atoms, a nitro group, as well as their salts.

Preparation process for new azabicycloheptene derivatives as defined by formula (I) of claim 1, as well as for their salts, characterized in that a cycloaddition is carried out between a product of formula (II):

in which the group

has the meaning already indicated, and a product of formula (III):

in which R₁, R₂, n, X, X₁, Y and R₃ have the meaning already indicated, in order to obtain the product of formula (I) in which R₁, R₂, n, X, X₁, Y, R₃,

have the meaning already indicated, which if appropriate can be salified.

Preparation process according to claim 16, characterized in that the cycloaddition between the product of formula (II) and the product of formula (III) is carried out in an apolar organic solvent such as benzene in the presence of an amine such as triethylamine.

Medicaments, characterized in that they are constituted by the new azabicycloheptene derivatives as defined by formula (I) of claim 1, as well as by their pharmaceutically acceptable salts.

Medicaments, characterized in that they are constituted by the new azabicycloheptene derivatives as defined in any one of claims 2 to 15, as well as by their pharmaceutically acceptable salts.

Pharmaceutical compositions, characterized in that they contain as active ingredient, at least one of the medicaments as defined in any one of claims 18 or 19.

EP199004001101989-01-161990-01-16Azabicycloheptene derivatives and their salts, process for their preparation, their use as medicaments and compositions containing them
Expired - LifetimeEP0379416B1
(en)

system for storing fluid removed from a tissue site, the apparatus for storing liquid from a tissue site, the method for storing liquid from a tissue site, and method for manufacturing an apparatus for storing liquid from a tissue site

"Treatment system with reduced dynamic pressure for treating a tissue site on a patient, the method of producing a treatment system with reduced dynamic pressure for treating a tissue site on the patient, a method for treating a tissue site on a patient, and reduced pressure application member "