The genetic parameters usually studied refer to genetic variances in its addictive and non-addictive components, to heritability coefficient (lato and stricto sensu), and tothe interactions between genetic and environmental effects and genetic correlations among these characters (Silveira, 2007).

Aimed at students and experienced scientists studying DNA sequence alterations, this reference compares and evaluates the technical choices available in detecting genetic variances in the context of pharmacogenomics.

Non-iterative least square weighted analysis was applied for goodness of fit for genetic (additive genetic variance DR and dominance HR) and two environmental (within family environment E1 and between family environment E2) components.

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