Epilepsy remains one of the most challenging diseases worldwide. According to the WHO, ∼50 million people around the world experience epilepsy with all its implications on the patient’s overall quality of life and social life as well as social stigma. The causes of epilepsy are mostly unknown. Epilepsy treatment is considered as a huge economic burden on the patient and health care systems. This review aimed to shed light on the different types of epilepsy, the different mechanisms of action of the most novel antiepileptic drugs in the market, as well as the current antiepileptic drugs under investigation and undergoing clinical trials.