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Dupuytren's contracture treatment. Syringe and two vials (powder and solvent) of collagenase to be prepared (by mixing) and injected into the hand of a patient with Dupuytren's contracture. This condition causes one or more fingers to become fixed in a bent position. Dupuytren's contracture occurs when tissue in the palm of the hand thickens and shortens, preventing the tendons attached to the fingers from moving freely. Surgery attempts to free the tendons, but does not always work. In this case, treatment was by the injection of collagenase (Xiapex), an enzyme that attacks collagen.