Sixteen people have been wounded in shootings citywide since Friday evening, according to police, including two people shot on the Dan Ryan Expressway and four people shot within 10 minutes in the same West Side neighborhood.

The most recent shooting was about 3:25 a.m. Saturday, a 24-year-old man was shot in the Heart of Chicago neighborhood on the West Side, said Officer Hector Alfaro, a spokesman for the Chicago Police Department.

He was in the front passenger seat of a car in the 2000 block of West 19th Street when someone walked up and fired shots. The man was struck in the upper thigh and driven to University of Illinois Hospital, where his condition was stabilized.

In other shootings:

• At 3:05 a.m. Saturday, two people were shot in Grand Crossing neighborhood on the South Side, police said.

A 25-year-old man and an 18-year-old woman were on the sidewalk in the 7300 block of South Maryland Avenue when someone fired shots from a black sedan, Alfaro said.

The woman was shot in the ankle, shoulder, neck and hand. She was transported in critical condition to Jackson Park Hospital.

The man was shot in the thigh and taken to Stroger Hospital. His condition was stabilized.

• About 2:30 a.m. Saturday, a 34-year-old man and a 15-year-old boy were shot on the Dan Ryan Expressway, according to Illinois State Police.

They were struck in a southbound lane near 71st Street on the South Side and drove themselves to Ingalls Memorial Hospital in south suburban Harvey, according to state police. No information was immediately available about their ages, conditions or the nature of their injuries.

Part of the expressway was shut down starting about 4:45 a.m. so police could search for shell casings, state police said. As of 5:15 a.m., a state police spokesman said lanes were expected to reopen shortly. It was unknown whether any shell casings were found. Chicago police did not immediately have information on the shooting.

State police said there was a third person in the car who was not injured.

• At 2:10 a.m. Saturday, a 27-year-old man was shot in the Englewood neighborhood on the South Side, police said. He was on the sidewalk in the 7400 block of South Eggleston Avenue when he heard shots and realized he had been struck. He was hit in the right knee and left hip and went to Advocate Christ Medical Center. His condition was stabilized.

• At 1:25 a.m. Saturday, a 31-year-old man was shot in the Humboldt Park neighborhood on the West Side, Alfaro said. He was discovered by his friend in the 2700 block of West Augusta Boulevard with gunshot wounds to the face, neck and abdomen. A friend took him to Stroger Hospital, where he was listed in serious condition.

• At 11:50 p.m. Friday, a 19-year-old man was shot multiple times in the West Englewood neighborhood on the South Side, police said. He was in a parked sedan in the 7100 block of South Ashland Avenue when someone approached and fired shots, Alfaro said. He was hit in the leg, ankle, buttock and abdomen; he went to Holy Cross Hospital but was transferred to Mount Sinai Hospital in serious condition.

• At 11:05 p.m. Friday, an 18-year-old man was shot in South Austin, Officer Alfaro said. He was walking home in the 5900 block of West Augusta Boulevard when someone walked up and shot him, Alfaro said. He was struck in the right arm and went to Mount Sinai Hospital. His condition had stabilized.

Ten minutes earlier, three other men were shot in South Austin, police said.

They told police they were in the 400 block of South Central Avenue when they heard gunfire and realized they had been shot.

A 30-year-old man was shot in the face, chest and abdomen. He was taken in critical condition to Loretto Hospital and then transferred to Mount Sinai Hospital.

A 38-year-old man was shot in the buttocks and went to Loretto Hospital; his condition was stabilized.

A 41-year-old man was struck in the left ankle and upper right shoulder; he went to Mount Sinai Hospital and his condition was stabilized.

• At 7:50 p.m. Friday, two men were shot in the Brighton Park neighborhood, said Chicago police spokesman Officer Ron Gaines. The shooting, which Gaines said may have been a drive-by, occurred in the 4300 block of South Campbell Avenue.

An 18-year-old man was shot in the leg and grazed in the head. He went to Mount Sinai Hospital, and his condition was stabilized. A 20-year-old man was grazed in the back and taken to St. Anthony Hospital in good condition.

• At 7:20 p.m. Friday, two people were wounded when a disgruntled patron opened fire in a restaurant in Bronzeville, according to Officer Veejay Zala, a Chicago police spokesman.

A male patron was arguing with an unidentified female at the restaurant in the 4300 block of South Prairie Avenue and was asked to leave, Zala said.

The man returned and fired shots, hitting a 37-year-old man in the right leg and a 25-year-old woman in the left leg, he said.

It was not clear if the gunman was aiming at the victims, Zala said.

The woman was taken to Northwestern Memorial Hospital, Zala said, and the man was taken to Stroger Hospital. Both of their conditions had stabilized, police said.

• Earlier Friday, a 29-year-old man was shot in the leg in the West Englewood neighborhood. The man was shot around 1:40 p.m. in the 6400 block of South Hermitage Avenue. He was taken to Christ Medical Center, where his condition was stabilized.

Chicago Tribune's Geoff Ziezulewicz and Grace Wong contributed.

Updated at 1:25 p.m. 10-5-2015: An earlier version of this story contained a different address for the Prairie Avenue, Hermitage Avenue and 19th Street shootings.