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Cymbalta For Physical Pain in Depression: Fact or Fiction?

It has become increasingly clear that depressed patients quite often suffer from some degree of physical pain, which may adversely impact treatment outcome. Indeed, research suggests that as the pain severity of patients increases, the odds of achieving a successful antidepressant response decreases (Bair MJ et al., Psychosom Med 2004;66:17-22). Given that pain is associated with poor treatment response, a clear need exists for treatments that can effectively target both depression and physical pain.
Enter Cymbalta (duloxetine), Eli Lilly’s popular antidepressant.

All editorial content is peer reviewed by the editorial board. Dr. Albucher, Dr. Balt, Dr. Gardiner, Dr. Goldberg, Dr. Lyman, Dr. Megna, Dr. Mick, Dr. Posternak, Dr. Spielmans, and Dr. Zuckerman have disclosed that they have no relevant financial or other interests in any commercial companies pertaining to this educational activity. Dr. Balt discloses that his spouse is employed as a sales representative for Otsuka America, Inc.

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