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Accession Number : AD0648015

Title : THE EFFECT OF ORAL NEOMYCIN THERAPY FOLLOWING WHOLE-BODY X-IRRADIATION OF RATS

Abstract : The study was designed to examine the beneficial effects of oral antibiotic treatment with neomycin following total-body X-irradiation of Sprague-Dawley rats. Survival times of irradiated, neomycin treated male rats were compared with those of irradiated, untreated controls. Eleven selected radiation exposures, beginning at 700 R and extending in increments to 2500 R, were used. Thirty-day lethality was also evaluated at and below exposures of 1100 R. Neomycin treatment resulted in a significant prolongation of the mean survival times of irradiated animals at exposures between 800 R and 1500 R. At exposures between 1500 R and 2500 R, a small but consistent prolongation of mean survival time resulted. For exposures between 700 R and 1100 R, the 30-day lethality was consistently lower for the neomycin treated rats. It is suggested that postradiation treatment with oral neomycin, administered every 12 hours, can effect an increase in the mean survival time of whole-body X-irradiated rats.