Ronksley and colleagues asserted that the association between moderate alcohol consumption and reduced mortality risk was “beyond question.”1 We reviewed all 67 studies that generated the 84 articles in their meta-analysis. All but two had at least one of six serious methodological problems, and these two had mixed findings (figure⇓); see http://carbc.ca/Portals/0/News/FeatureSupplement201203.pdf for bibliography).