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Objective A major obstacle to advances in veterinary immunology and disease control is the lack of sufficient immunological reagents specific for ruminants, swine, poultry, equine and aquaculture species. The goals of the project are to develop sets of reagents to begin to address this dearth.

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Targets of US-VIRN Cytokines and chemokines: bioactive recombinant proteins as well as Abs to them Ab to cytokines & chemokines: mAb pairs for ELISA, multiplex and ELISpot assays (in some cases this may include polyclonal Abs); single mAb for intracellular staining for cytokines mAbs to Igs isotypes and IgG subclasses mAb anti-CD molecules and T cell receptors: mAb reactive with native molecules and used to stain viable cells for flow cytometric analyses including cell sorting to purify cells by flow cytometry or magnetic beads; for anti-cytokine receptors mAb that block function and signaling

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New Products Our pipeline is dynamic – We receive a couple of requests a week. – We are happy to hear what products our customers would like to further their research

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Catfish Presented by Mel Wilson

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For catfish, the highest priority reagents have been and are mAbs that recognize B and T cell subsets and macrophages. Antibodies to inflammatory cytokines have also been requested. Our goal is to prove specificity by FACS, western blotting, and immunoprecipitation with peptide sequencing. Peer review publications: 8 Abstracts: 16 Oral presentations:17 VIRN:Catfish Species Report