Suboxone Drug Interactions

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Suboxone Drug Interactions Explained

The following sections explain in detail the potentially negative reactions that can occur when Suboxone is combined with any of the drugs listed above.

Alcohol

Consuming alcohol while using Suboxone could potentially increase your risk for serious side effects, such as extreme drowsiness, confusion, memory loss, or difficulty breathing. Do not drink alcohol while using Suboxone.

Benzodiazepines

Combining Suboxone with a benzodiazepine may increase the risk for serious problems, including death, particularly in the case of abuse or overdose. Normally, there is a limit, known as a "ceiling," to how much Suboxone can negatively affect breathing. However, benzodiazepines may increase this limit, allowing for dangerously slow or irregular breathing. Do not combine Suboxone with a benzodiazepine without your healthcare provider's approval and supervision.

CYP 3A4 Inducer Medications

The liver breaks down Suboxone using enzymes known as CYP 3A4 enzymes. Some other medications (known as CYP 3A4 inducers) can increase the activity of these enzymes. Combining Suboxone with one of these CYP 3A4 inducers may decrease the level of Suboxone in your body, making it less effective. Your healthcare provider may need to monitor you more closely to make sure Suboxone is still working effectively if you take Suboxone with a CYP 3A4 inducer.

CYP 3A4 Inhibitor Medications

The liver breaks down Suboxone using enzymes known as CYP 3A4 enzymes. Some other medications (known as CYP 3A4 inhibitors) can decrease the activity of these enzymes. Combining Suboxone with one of these CYP 3A4 inhibitors may increase the level of Suboxone in your body, increasing your risk for serious side effects, including drowsiness, confusion, and breathing difficulty. Your healthcare provider may monitor you more closely for side effects if you take Suboxone with a CYP 3A4 inhibitor.

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