CIDRF - Central Inter-Disciplinary Research Facility

To study the transcriptional control of CD147 expression in glioblastomas through cell lines -(DBT funded project6242-P71/RGCB/PMD/DBT/PJPH/2015)

09.22.2015

CD147 is a surface glycoprotein expressed on a wide range of cells including hematopoietic and non-hematopoietic cells. However, it is enriched on the plasma membrane of many human cancer cells and is also shown to be upregulated in cells exhibiting resistance to chemotherapeutic agents. Glioblastomas are the most frequently occurring tumors of the brain and also the most aggressive type among Gliomas. These cells have shown to over express CD147 and it is associated with tumor invasion, metastasis and poor prognosis. The upstream region of CD147 gene contains GC rich sequences and binding sites for many transcription factors. Through this project, we are studying the transcriptional factors that modulate CD 147 expression in aggressive glioma cells.

eM@n@gerTo study the transcriptional control of CD147 expression in glioblastomas through cell lines -(DBT funded project6242-P71/RGCB/PMD/DBT/PJPH/2015)09.22.2015

We Are….

Central Inter-Disciplinary Research Facility (CIDRF), DSIR, Govt. of India recognized research center to foster research emanating from ‘bed side’ to ‘bench’ and back to ‘bed side’ enabled by its association to two medical (MGMCRI, SSSMCRI) and one dental (IGIDS) institution with hospitals. CIDRF is intended to be an inter-disciplinary open forum for interaction between scientists and clinicians taking medical research to molecular levels so that clinical practice gets the strongest evidence base and support.

We Do…….

To fulfil our mission of ‘bedside’ to ‘bench’ to ‘bedside’ in healthcare at CIDRF we, the group of enthusiastic, young and competent researchers drawn from different disciplines of bio-medical sciences are into both exploration at the fundamental level and application at the translational level.