That alert is not a big concern. You could leave it or remove it depending upon which way you want a particular IE config set.

All that alert is showing is that the registry key that holds the setting used to "Lock the IE Home Page from user changes" is present on your system. If you ever used either SpywareBlaster or Spybot S&D (and actually several other tools) to "lock" that setting, then you will have that key present in your registry, and Ad-aware (and other tools including HijackThis) will flag it to let you know it is there.

These products alert on this simply because sometimes people did not choose to make that setting themselves. Some spyware that hijacks your home page can actually set the locked value in that key in order to keep the user from changing their home page back to what they want.

If that key is set to a value of 1, then the home page is locked from manual user changes via: IE > Tools menu > Internet Options... > General tab > Home Page section.

So, as I said, if you chose to set that in one of these other tools, then leave it. But, it won't hurt to delete it either.

Thanks for your prompt reply LWM! I did "lock" that setting through SpyBot S&D and SpywareBlaster. Is there a way to prevent that alert from showing up on future Ad-Aware scans without actually deleting it