Metal ions in biological systems by Helmut Sigel(
Book
)49
editions published
between
1973
and
2005
in
English and Undetermined
and held by
386 WorldCat member
libraries
worldwide
Volume 39, devoted soley to the vital research area on molybdenum and tungsten and their role in biology, offers a comprehensive
and timely account of this fascinating topic by 40 distinguished international authorities

Neurodegenerative diseases and metal ions by Astrid Sigel(
Book
)12
editions published
in
2006
in
English
and held by
164 WorldCat member
libraries
worldwide
About the Series ... Metal Ions in Life Sciences links coordination chemistry and biochemistry in their widest sense and thus
increases our understanding of the relationship between the chemistry of metals and life processes. The series reflects the
interdisciplinary nature of Biological Inorganic Chemistry and coordinates the efforts of scientists in fields like biochemistry,
inorganic chemistry, coordination chemistry, molecular and structural biology, enzymology, environmental chemistry, physiology,
toxicology, biophysics, pharmacy, and medicine

Metal-carbon bonds in enzymes and cofactors by Astrid Sigel(
Book
)19
editions published
between
2009
and
2015
in
English and Undetermined
and held by
153 WorldCat member
libraries
worldwide
This book covers the occurrence of a wide variety of metal-carbon bonds in living organisms, ranging from bacteria to humans

Metallothioneins and related chelators by Astrid Sigel(
Book
)19
editions published
between
2009
and
2015
in
English
and held by
153 WorldCat member
libraries
worldwide
An essential resource for scientists working in a wide range of disciplines from environmental toxicology and inorganic biochemistry
all the way through to physiology and medicine

The ubiquitous roles of cytochrome P450 proteins(
Book
)11
editions published
in
2007
in
English
and held by
145 WorldCat member
libraries
worldwide
Looking across the tree of life, it is amazing to find cytochrome P450 proteins represented in all life forms. Volume 3, devoted
solely to the vital and still expanding research area concerning P450s, offers in 17 stimulating chapters written by 36 internationally
recognized experts an authoritative and timely account of this fascinating subject. The Ubiquitous Roles of Cytochrome P450
Proteins highlights, supported by nearly 2700 references, more than 20 tables and 190 illustrations, the function of these
versatile catalysts which act as monooxygenases and insert an oxygen atom from dioxygen into a substrate molecule oxidizing
it. P450s are important in the biosynthesis of hormones and signaling molecules as well as in xenobiotic metabolism and detoxification
ranging from pharmaceuticals in humans to toxic substances in insects and plants. Mechanistic aspects and the design and engineering
of P450 systems for biotechnological applications are also covered. MILS-3 is essential for scientists working in the wide
range from bioinorganic chemistry all the way through to medicine including the clinic. This volume encompasses the breadth
of research efforts focused on P450s from structure to function including an appreciation of the diversity and complexity
of the biotransformations they catalyze. The introductory Chapter 1, setting the scene, explores the many different levels
at which these P450 enzymes (and their respective genes) have diverged in the process of evolution to yield the plethora of
enzymes that are now termed "P450 monooxygenases". This broad and unprecedented reactivity of P450 enzymes which contain a
heme iron center (most commonly iron(III)protoporphyrin IX) with a deprotonated cysteine side chain providing the fifth ligand
to iron, has challenged the "biomimetic community". Indeed, much has been accomplished over the past five decades, e.g., regarding
the understanding of the unusual activation of paramagnetic dioxygen by reductive oxygen clea

Nickel and its surprising impact in nature(
Book
)10
editions published
between
2006
and
2007
in
English
and held by
138 WorldCat member
libraries
worldwide
Helmut Sigel, Astrid Sigel and Roland K.O. Sigel, in close cooperation with John Wiley & Sons, launch a new Series 8220;Metal
Ions in Life Sciences8221;. The philosophy of the Series is based on the one successfully applied to a previous series publis

Biomineralization : from nature to application(
Book
)12
editions published
in
2008
in
English
and held by
118 WorldCat member
libraries
worldwide
Biomineralization is a hot topic in the area of materials, and this volume in the Metals Ions in Life Sciences series takes
a systematic approach, dealing with all aspects from the fundamentals to applications. Key biological features of biomineralization,
such as gene directed growth and the role of enzymes are covered, as are new areas, including copper/zinc in the jaws of invertebrates
or magnetic biomaterials that help birds with navigation

Organometallics in environment and toxicology(
Book
)13
editions published
between
2010
and
2015
in
English
and held by
116 WorldCat member
libraries
worldwide
"Organometallic compounds contain per definition a metal-carbon bond. Therefore, the present Volume 7 is related to the preceding
Volume 6, Metal-Carbon Bonds in Enzymes and Cofactors, which, as follows from its title, focused on living organisms. Now
the focus is on the role that organometal(loid)s play in the environment and in toxicology; naturally, here again living systems
are involved in the synthesis, transformation, remediation, detoxification, etc."--Preface

Metal ions in toxicology : effects, interactions, interdependencies by Roland K. O Sigel(
Book
)15
editions published
between
2010
and
2015
in
English and Undetermined
and held by
77 WorldCat member
libraries
worldwide
Volume 8, solely devoted to the toxicology of metals and metalloids as well as their compounds, focuses on human health. Not
surprisingly, all related research areas are rapidly developing due to the role of metals and metalloids in the environment,
for the work place, for food and water supply, etc. Written by 40 internationally recognized experts, the 14 stimulating chapters
provide an authoritative and timely resource for scientists working in the wide range from analytical, physical, inorganic,
and environmental biochemistry all the way through to toxicology, physiology, and medicine. Volu

Interplay between metal ions and nucleic acids by Astrid Sigel(
Book
)14
editions published
between
2011
and
2014
in
English and Undetermined
and held by
68 WorldCat member
libraries
worldwide
The Metal Ions in Life Sciences series links coordination chemistry and biochemistry in their widest sense and thus increases
our understanding of the relationship between the chemistry of metals and life processes. The series reflects the interdisciplinary
nature of Biological Inorganic Chemistry and coordinates the efforts of scientists in fields like biochemistry, inorganic
and coordination chemistry, molecular and structural biology, enzymology, environmental chemistry, physiology, toxicology,
biophysics, pharmacy, and medicine. Consequently, the volumes are an essential source for researchers active in these and
related fields as well as teachers preparing courses, e.g., in Bioinorganic Chemistry. MILS-10: Interplay between Metal Ions
and Nucleic Acids provides in an authoritative and timely manner in 12 stimulating chapters, written by 24 internationally
recognized experts from 8 nations, and supported by nearly 1500 references, about 20 tables, and 125 illustrations, many in
color, a most up-to-date view on metal ion-nucleic acid interactions; the characterization of which is covered in solution
and in the solid state. The volume concentrates on modern developments encompassing topics in the wide range from G-quadruplexes
via DNAzymes, catalysis at the DNA scaffold, and metal-mediated base pairs to peptide nucleic acids (PNAs) being thus of relevance,
e.g., for chemistry and nanotechnology but also for molecular biology and (genetic) diagnostics. The Editors Astrid Sigel,
Helmut Sigel and Roland K. O. Sigel have long-standing interests in Biological Inorganic Chemistry. They published on metal
ion interactions with nucleotides and nucleic acids and on related topics, and edited previously 44 volumes in the series
Metal Ions in Biological Systems

Structural and catalytic roles of metal ions in RNA(
Book
)9
editions published
between
2011
and
2015
in
English
and held by
63 WorldCat member
libraries
worldwide
The discovery of ribozymes triggered a huge interest in the chemistry and biology of RNAs. Much of the recently made progress
focusing on metal ions is addressed in Volume 9. This book, written by 28 internationally recognized experts, provides a most
up-to-date view and it is thus of special relevance for colleagues teaching courses in biological inorganic chemistry and
for researchers dealing, e.g., with nucleic acids, gene expression, and enzymology, but also for those in analytical and bioinorganic
chemistry or biophysics. Structural and Catalytic Roles of Metal Ions in RNA describes metal ion-binding motives, methods
to detect and characterize metal ion binding sites, and the role of metal ions in folding and catalysis. It deals with diffuse
metal ion binding, RNA quadruplexes, the regulation of riboswitches, metal ions and ribozymes, including artificial ribozymes.
The ribosome, ribozymes and redox cofactors, as well as the binding of kinetically inert metal ions to RNA are also considered

Cadmium : from toxicity to essentiality by Astrid Sigel(
Book
)11
editions published
between
2012
and
2013
in
English
and held by
35 WorldCat member
libraries
worldwide
Cadmium: From Toxicity to Essentiality, MILS-11 provides in an authoritative and timely manner in 16 stimulating chapters,
written by 40 internationally recognized experts from 11 nations, and supported by more than 2600 references, 35 tables, and
over 100 illustrations, many in color, a most up-to-date view on the role of cadmium for life, presently a vibrant research
area. MILS-11 covers the bioinorganic chemistry of Cd(II), its biogeochemistry, anthropogenic release into the environment,
and speciation in the atmosphere, waters, soils, and sediments. The analytical tools for Cd determination, its imaging in
cells, and the use of 113Cd NMR to probe Zn(II) and Ca(II) proteins are summarized, as are Cd(II) interactions with nucleotides,
nucleic acids, amino acids, and proteins including metallothioneins. The phytoremediation by Cd(II)-accumulating plants, etc.,
the toxicology of Cd(II), its damage to mammalian organs, and its role as a carcinogen for humans, are highlighted. The book
terminates with a fascinating report on the use of Cd(II) in carbonic anhydrase of certain marine phytoplankton species.Astrid
Sigel, Helmut Sigel, and Roland K. O. Sigel have long-standing interests in Biological Inorganic Chemistry. Their research
focuses on metal ion interactions with nucleotides and nucleic acids and on related topics. They edited previously 44 volumes
in the series Metal Ions in Biological Systems

Interrelations between essential metal ions and human diseases by Astrid Sigel(
Book
)8
editions published
in
2013
in
English
and held by
26 WorldCat member
libraries
worldwide
"MILS-13 provides an up-to-date review on the relationships between essential metals and human diseases, covering 13 metals
and 3 metalloids: The bulk metals sodium, potassium, magnesium, and calcium, plus the trace elements manganese, iron, cobalt,
copper, zinc, molybdenum, and selenium, all of which are essential for life. Also covered are chromium, vanadium, nickel,
silicon, and arsenic, which have been proposed as being essential for humans in the 2nd half of the last century. However,
if at all, they are needed only in ultra-trace amounts, and because of their prevalence in the environment, it has been difficult
to prove whether or not they are required. In any case, all these elements are toxic in higher concentrations and therefore,
transport and cellular concentrations of at least the essential ones, are tightly controlled; hence, their homeostasis and
role for life, including deficiency or overload, and their links to illnesses, including cancer and neurological disorders,
are thoroughly discussed. Indeed, it is an old wisdom that metals are indispensable for life. Therefore, volume 13 provides
in an authoritative and timely manner in 16 stimulating chapters, written by 29 internationally recognized experts from 7
nations, and supported by more than 2750 references, and over 20 tables and 80 illustrations, many in color, a most up-to-date
view on the vibrant research area of the Interrelations between essential metal ions and human diseases"--Publisher's description