Role of cell cycle in cell fate decision

Fabienne PITUELLO

DR CNRS05 61 55 67 39

Team members

Researcher

Eric AGIUS

Sophie BEL-VIALAR

Technical staff

François MEDEVIELLE

PhD

Mélanie ROUSSAT

Presentation

Our aim is to understand how the cell cycle affects cell fate decisions in organ development and homeostasis using as a paradigm the developing nervous system. Deciphering the core machinery of cell cycle has been mostly the focus of cell biologists, while, developmental biologists identified the signaling pathways and transcriptional programs controlling cell fate choices. The interplay between these two fundamental aspects of biology remained largely unexplored. The goal of our project is to implement molecular analyses with advanced technique in time-lapse imaging to elucidate how changes in cell cycle features switch a proliferating neural progenitor into a differentiating neuron.