0. DOCID:7094 SCORE: 0.00427210155117307DOCNO: 7008297OWNER: NLMSTATUS: MEDLINEQUALIFIER: epidemiologyQUALIFIER: analysisQUALIFIER: immunologyQUALIFIER: epidemiologyAUTHOR: L Dominioni LAUTHOR: R Dionigi RAUTHOR: M Campani MPUBTYPE: Journal ArticleJOURNALTITLE: Tumori. COUNTRY: ITALYTITLE: Postoperative infections and variations of complement components in cancer patients.PUBDATE: 19801001
Sequential determinations of C4 and factor B serum levels were performed pre- and postoperatively in 56 cancer patients. Patients who underwent radical mastectomy and excision of melanoma had an incidence of surgical infections of 7% and 15%, respectively, and showed a significant postoperative acute-phase increase of C4 and factor B serum levels. A higher incidence of postoperative infections, mostly Gram negative, was recorded in patients who underwent gastric resection (35%) and colorectal resection (73%); these failed to show an early acute-phase response of complement postoperatively. The results of this study confirm the high susceptibility of cancer patients to postoperative infections. Moreover, the lack of postoperative acute-phase increase of C4 and factor B observed in cancer patients who developed postoperative infections suggests an active role of complement in host defense mechanisms against surgical infections.

1. DOCID:7136 SCORE: 0.00427210140582518DOCNO: 75080OWNER: NLMSTATUS: MEDLINEDESCRIPTOR: CryosurgeryQUALIFIER: surgeryAUTHOR: A A Gage AAPUBTYPE: Journal ArticleJOURNALTITLE: Comprehensive therapy. COUNTRY: UNITED STATESTITLE: Cryosurgery for cancer.PUBDATE: 19780201
Cryosurgery has a wide range of uses for the destruction of tumours. Acceptability among dermatologists for the treatment of skin cancer appears high. In the treatment of oral cancer, cryosurgery is not yet widely accepted, but it should be more commonly used for early cancer and in the management of selected problems in therapy. It has established a reasonably firm place in the treatment of prostatic cancer, perhaps because of continued interest in the immunologic benefits, while its use in gynecologic organs is limited to carcinoma in situ or to selected patients with advanced cancer. In all these areas, it has been used with surprisingly good results in selected patients who were high risks under conventional methods of therapy. The trial of cryosurgery in the treatment of bone tumors should prove its efficacy. Today's interest in cryosurgery is consistent with the current trend to conservatism in cancer surgery.

2. DOCID:1773 SCORE: 0.00258117119380698DOCNO: 1159922OWNER: NLMSTATUS: MEDLINEDESCRIPTOR: ProstatectomyQUALIFIER: surgeryAUTHOR: F H Schroeder FHAUTHOR: E Belt EPUBTYPE: Journal ArticleJOURNALTITLE: The Journal of urology. COUNTRY: UNITED STATESTITLE: Carcinoma of the prostate: a study of 213 patients with stage C tumors treated by total perineal prostatectomy.PUBDATE: 19750801
The effects of age, histological grade and clinical extension of carcinoma of the prostate are analyzed in a series of 213 patients with stage C carcinomas treated by total perineal prostatectomy. Survival data and the incidence of local recurrence, distant metastases and deaths from cancer of the prostate are the parameters used for comparison with 132 stage B patients, 70 patients with seminal vesicle invasion and data from the literature. Long-term survivors in the young age group and some long-term survivors with high grade lesions are good arguments for the possible curability of early stage C carcinoma of the prostate by total prostatectomy. Correct surgical staging of these tumors by previous pelvic lymphadenectomy is mandatory.

4. DOCID:9952 SCORE: 0.00204403443166534DOCNO: 6865687OWNER: NLMSTATUS: MEDLINEDESCRIPTOR: Preoperative CareQUALIFIER: radiation effectsQUALIFIER: therapyAUTHOR: A I Popov AIPUBTYPE: Journal ArticleJOURNALTITLE: Meditsinskaia radiologiia. COUNTRY: USSRTITLE: [Effect of preoperative radiation therapy on intravascular blood coagulation in the combined treatment of kidney cancer patients]PUBDATE: 19830601
Hemostasis has been studied over time in 137 patients with renal cancer. Of these, 69 underwent surgery only, 68 received combined treatment with preoperative large fractionation radiotherapy. It has been established that renal cancer development in the body stimulates intravascular blood coagulation (IVBC). In the patients with renal cancer who were radiation treated, IVBC activation was more noticeable than in those who had surgery only. To prevent IVBC activation and the development of the DIVC-syndrome, it is proposed to prescribe deaggregates in the period of preoperative therapy and heparin in the postoperative period.

5. DOCID:3839 SCORE: 0.00197575557145546DOCNO: 1028554OWNER: NLMSTATUS: MEDLINEQUALIFIER: adverse effectsPUBTYPE: Journal ArticleJOURNALTITLE: Consumer reports. COUNTRY: UNITED STATESTITLE: Estrogen therapy: the dangerous road to Shangri-La.PUBDATE: 19761101
The use of estrogens almost tripled during the 1965-75 period, with usage concentrated as a cure-all for aging, for the degenerative diseases associated with aging, and for the emotional difficulties of middle age. 3 separate studies published in the last year have shown a high level of association between estrogen use and the development of endometrial cancer. Results of these studies coupled with the significant recent increase in the incidence of cancer in women over 50 who are in the high socioeconomic groups--the groups most likely to use estrogen therapy--emphasize the association. The U.S. FDA has proposed a modification in the labeling for estrogens, and a package insert for patients which would warn of possible hazards of estrogen therapy. It is recommended that estrogen be used only for vasomotor symptoms and vaginal atrophy. The lowest possible effective dosage should be used and for the shortest possible amount of time. Earlier studies had suggested that estrogen replacement therapy might protect against breast cancer; most recent studies suggest the opposite. In addition, estrogen may trigger high blood pressure and increase some blood clotting. Women with high blood pressure or a family history of early heart attacks are contraindicated from using estrogen therapy. Even for the treatment of osteoporosis, there may be safer alternative therapies. Women are cautioned as to their own responsibilities when taking estrogens.

6. DOCID:2394 SCORE: 0.00196296897813452DOCNO: 1258933OWNER: NLMSTATUS: MEDLINEQUALIFIER: adverse effectsQUALIFIER: chemically inducedAUTHOR: H K Ziel HKAUTHOR: W D Finkle WDPUBTYPE: Journal ArticleJOURNALTITLE: American journal of obstetrics and gynecology. COUNTRY: UNITED STATESTITLE: Association of estrone with the development of endometrial carcinoma.PUBDATE: 19760401
Although few clinicians suspect estrogen as the prime cause of endometrial carcinoma, a retrospective study showed the following among postmenopausal women: 70 per cent of those with endometrial carcinoma and only 23 per cent of matched control subjects used estrogen systemically. Endometrial cancer developed an average of five years earlier in those taking than in those not receiving estrogen. Forty-two per cent of those with endometrial cancer had received estrogen three years or more. Most significantly, conjugated estrogens were used by 89 per cent of postmenopausal cancer patients who had received any estrogenic substance. The increased risk of endometrial cancer for all patients receiving conjugated estrogen (the risk ratio) was 7.4. This risk ratio increased with duration of conjugated estrogen exposure, from 4.6 in patients with less than three years' exposure to 9.2 in patients with three or more years' exposure.

7. DOCID:6892 SCORE: 0.00170947391268785DOCNO: 556273OWNER: NLMSTATUS: MEDLINEDESCRIPTOR: TendonsQUALIFIER: pathologyQUALIFIER: pathologyQUALIFIER: pathologyAUTHOR: T O Ekfors TOAUTHOR: V Rantakokko VPUBTYPE: Journal ArticleJOURNALTITLE: Pathology, research and practice. COUNTRY: GERMANY, WESTTITLE: Clear cell sarcoma of tendons and aponeuroses: malignant melanoma of soft tissues? Report of four cases.PUBDATE: 19791201
In a survey of 246 soft tissue sarcomas in the extremities and limb girdles reported to the Finnish Cancer Registry in 1960-1969, two clear cell sarcomas of tendons and aponeurones were diagnosed. We subsequently diagnosed two more examples. Three tumors were located in the foot and one in the wrist. The histology of the tumors was characteristic, and three of them were shown to contain brown pigment tinctorially indistinguishable from melanin. The pigment could be bleached with potassium permanganate. Ultrastructural studies performed in the most recent case revealed premelanosomes in the cytoplasm of tumor cells. Increasing evidence in the literature and results of the present study seem to suggest that clear cell sarcoma of tendons and aponeuroses represents a soft tissue malignant melanoma.

8. DOCID:7606 SCORE: 0.00170757839798162DOCNO: 7281688OWNER: NLMSTATUS: MEDLINEQUALIFIER: pathologyAUTHOR: P Hermanek PPUBTYPE: Journal ArticleJOURNALTITLE: Wiener klinische Wochenschrift. COUNTRY: AUSTRIATITLE: [Pathology of urological tumours--methods, functions, results (author's transl)]PUBDATE: 19810301
The primary requirement of clinically-oriented tumour pathology is an accurate histological technique. Multiple-step sections are usually required in processing biopsies or lymph nodes. Furthermore, large block sections have proven to be very valuable. The intraoperative examination of frozen sections is of great importance for operations tailored to the specific situation. A new, automated histophotometric method for intraoperative diagnosis--which could be operated by auxiliary staff--is being put to trial at the present time. Basic requirements of modern tumour pathology are exact typing, grading and staging, as well as intensive participation in clinical cancer registration. Tumour pathology not only provides a reliable diagnosis, but also helps in making therapeutic decisions, establishing the prognosis in an individual case and in evaluating therapeutic results. New results of tumour pathology in renal cell cancer, carcinoma of the urinary bladder and testicular tumours form the basis of histology- and stage-oriented cancer treatment in urological tumours.

11. DOCID:15398 SCORE: 0.00143760230856576DOCNO: 2681905OWNER: NLMSTATUS: MEDLINEQUALIFIER: complicationsQUALIFIER: complicationsQUALIFIER: complicationsQUALIFIER: complicationsQUALIFIER: adverse effectsAUTHOR: R Koike RAUTHOR: M Sasaki MAUTHOR: K Kuroda KAFFILIATION: Department of Thoracic Surgery, Hirakata Municipal Hospital, Osaka, Japan.PUBTYPE: Case ReportsPUBTYPE: Journal ArticlePUBTYPE: ReviewJOURNALTITLE: The Japanese journal of surgery. COUNTRY: JAPANTITLE: Lung cancer coexisting with bullae.PUBDATE: 19890701
Scattered reports have suggested the association of cancer with bullous disease. We report herein, two surgical cases of lung cancer arising from bullae. Both the patients were males who smoked heavily and the generation of cancer was found simultaneously with the discovery of the bulla. At thoracotomy, it was found that the cancer had arisen from the firm, scarred and contracted area adjacent to the bulla wall. On the basis of this experience and review of the literature, it is suggested that physicians should always pay careful attention to the generation and complication of cancer while treating bullous disease in heavy smoking individuals.

13. DOCID:14360 SCORE: 0.00143640035371564DOCNO: 3195731AUTHOR: J E Downing JEAUTHOR: E H Busch EHAUTHOR: P M Stedman PMAFFILIATION: Department of Anesthesiology, Ochsner Clinic, New Orleans, LA 70121.PUBTYPE: Journal ArticleJOURNALTITLE: Anesthesia and analgesia. COUNTRY: UNITED STATESTITLE: Epidural morphine delivered by a percutaneous epidural catheter for outpatient treatment of cancer pain.PUBDATE: 19881201
Twenty-three outpatients with cancer pain refractory to other methods of pain control were treated with epidural morphine (EM) delivered through a chronically placed percutaneous lumbar epidural catheter. Patients and their families were taught to administer EM at home. Mean EM doses ranged from 18 to 31 mg/day. Mean catheter lifespan was 6.3 weeks. There were no catheter-related infections or cases of respiratory depression. After 2500 patient treatment days, we have found this method to be a safe and effective method of cancer pain management in outpatients.

14. DOCID:7388 SCORE: 0.00141317726849983DOCNO: 418657OWNER: NLMSTATUS: MEDLINEQUALIFIER: classificationAUTHOR: S Hainline SAUTHOR: L Myers LAUTHOR: R McLelland RAUTHOR: J Newell JAUTHOR: S Grufferman SAUTHOR: W Shingleton WPUBTYPE: Journal ArticleJOURNALTITLE: AJR. American journal of roentgenology. COUNTRY: UNITED STATESTITLE: Mammographic patterns and risk of breast cancer.PUBDATE: 19780601
A study of 171 breast cancer cases matched by age and race to asymptomatic controls was undertaken to check Wolfe's assertion [1, 2] that breast cancer risk depends strongly on the mammographic classifications N1, P1, P2, and DY. The classifications were made blindly relative to all variables, including the case-control factor. Distribution of the four categories among the breast cancer patients in this study was consistent with the distribution found by Wolfe. (P = .46). Our age-standardized risk ratio estimates of the categories, relative to N1, are 1.5 for P1, 2.7 for P2, and 7.2 for DY. While not as striking as Wolfe's estimates, the same monotone trend is evident, and the cases and controls differ significantly with respect to the distributions of the four categories (P less than .01).