Pharmaceutical

Who thinks outside the box to get more in it?

We do! Our pharmaceutical team prides itself on advancing drug delivery with sophisticated science-based solutions. Our global centers of excellence contain the latest equipment and our research scientists and formulators are ready to work with you from concept to commercialization. Now sold as Klucel™, Ashland introduced hydroxypropylcellulose (HPC) - an excipient that changed the drug delivery platform - to the market 65 years ago. And while others have followed, it was the solvers at Ashland who discovered it. Our full line of products combined with our global research and development capabilities can help deliver your drugs when and where they're needed resulting in better outcomes for patients and pharmaceutical companies alike. With its significant history in pharmaceuticals and one of the widest available range of products for oral solid-dosage forms Ashland has a solid foundation to help find excipient and formulation solutions for you. Our global manufacturing sites, that operate in accordance with cGMP standards, provide consistently high quality products regardless of origin. As a full-service resource, Ashland can help you bind, coat, dissolve and deliver solutions that can yield better patient outcomes.

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Ashland Supports

Oral Solid Dosage Form

Prescriptions for successful solutions

While an apple a day keeps the doctor away (and the teacher happy) there comes a time, in almost everyone's life, when medication - in tablet form - is needed. Our knowledge of the structure function of polymers, combined with our extensive product line can help you bind, coat, dissolve, and effectively deliver complex drug molecules where and when they're needed - making medication easier to swallow. And, easy to swallow medication often yields better patient compliance, which, in turn, yields better outcomes for everyone - a winning scenario. From concept to commericialization, working with Ashland makes medicine easy to swallow.

Ashland is unsurpassed in its ability to develop solutions for effective and efficient solutions to deliver today's complex drug molecules where and when they are needed. Our centers of excellence and manufacturing sites operate in accordance with cGMP standards. Our various chemistries and technologies are supported by a global team of research and development scientists. Ashland stands ready collaborate with you on new solutions to help take you from concept to commercialization. Our solutions include:

Increasing the solubility of active pharmaceutical ingredients with low or no solubility

Understanding implications of continuous manufacturing technology for oral dosage production

Ongoing research provides a foundation for advanced technical solutions to address these and future formulation and manufacturing challenges. Ashland provides formulators with industry-changing technologies and unique opportunities for research and development collaboration.

Oral Liquid Dosage Form

Ashland helps the medicine go down

A spoonful of sugar may help the medicine go down, but the folks at Ashland, with their expertise in pharmaceutical formulations, know that there's more to it. Effective drug delivery in liquid form, poses some unique challenges with rheology, texture, consistency and stability at the top of the list. Ashland's motto - We are solvers - is also our attitude and goal and we want to work with you to find new sophisticated solutions to advance drug delivery. With our extensive polymer portfolio, R&D capaitilities and testing facilities combined with your complex drug molecues can yield solutions for effective, useable ways to deliver and improve the bioavailability of needed medication.

Targeted rheology, texture and stabilization in oral-liquid dosage forms play vital roles in delivery of the pharmaceutical components. The water binding and viscosity modification capacities of many of Ashland’s polymers thicken and suspend in liquids, gels, syrups and semi-solid dosage forms for improved patient satisfaction and shelf life of products. Contact us to learn more.

Other Dosage Form

Solutions that are more than skin deep

Our solutions are more than skin deep. Through transdermal and topical applications, skin can be an effective way to deliver some medications. Regardless of whether the drug is being delivered via gel, lotion, cream, ointment or foam, features including texture, adhesion, and spreadability, as well as feel and smell, are important attributes to consider for optimal patient compliance. For topical and transdermal application, Ashland's pharmacuetical team works with the talented skin care team to find alluring and luxurious ways to effectively and efficiently formulate topical and transdermal applications.

Topical treatments are administered to skin or mucous membranes to alleviate a variety of conditions. These treatments broadly encompass creams, foams, gels, lotions and ointments. There are a number of sought-after attributes for conferring desired properties to a topical formulation: rheology control, spreadability, adhesion and diffusion control. Ashland offers high-quality cellulose ethers such as Natrosol™ 250 hydroxyethylcellulose, Klucel™ hydroxypropylcellulose and Aqualon™ sodium carboxymethylcellulose to deliver these properties. Some of the topical film formers offered in our skin-care product lines are also suitable for use in topical applications. Plasdone™ povidone is also a good film former for topical applications. Contact us to learn more about our solutions for topical and transdermal applications.

Bioavailability Enhancement

Poorly water-soluble active pharmaceutical ingredients (APIs) pose ongoing development challenges. Common techniques to improve API solubility, such as salt formation and particle-size reduction, do not always result in the solubility levels required to achieve desired bioavailability.

Disintegrants

Effective tablet disintegration is necessary for active pharmaceutical ingredient (API) dissolution and release. And at Ashland, we know that this is often a challenge that needs solving, and we're eager help.

Film Coatings

Your tablet film coatings are the outward expression of your product’s quality. That’s why our team is always solving – to provide you with effective, high-quality coatings that perform in the manner you require, while also delivering the right color and aesthetic.

Modified Release

Ashland offers sophisticated solutions to address a wide variety of controlled release delivery models. The team of passionate, tenacious solvers at Ashland can deliver controlled release solutions that can improve the efficacy of your drug molecules.

Tablet Binders

Pharmaceutical companies want smooth, round, uniform tablets for their products delivered as oral solid dosage. The pharmaceutical solvers at Ashland stand ready to help identify and select the best binder for your situation.

EXCiPACT Certifications

With six manufacturing facilities already certified by EXCiPACT, Ashland is well on its way to have all pharmaceutical excipient facilities certified by the end of 2017. Ashland continues its quest for high quality, which in turn, simplifies and streamlines your sourcing options.