That really depends on what you would like to do. Just being good at all MOBAs is mostly a skilled understanding not to go under turrets. All MOBAs play different and the play styles are a totally different ballpark. You have to memorize characters, items, lanes, classes, and upgrades. If I was you I would pick up one and watch some pros play in the lane you are most wanting to conquer on twitch. Once you play a few games and get the hang of it, then you can start looking at alternative builds and competitive play. Just my two cents!