Preview of 'House M.D.' 5th Season Finale: Both Sides Now - Featured

"You will definitely be talking about this ending," Fox said on its promo for "House M.D." season finale. On May 11, House and the team are intrigued by Scott (guest star Ashton Holmes), a man whose left brain and right brain operate independently, leaving him with two distinct personalities and no control over some of his actions.

As the two sides of Scott's brain struggle for dominance, his warring personalities make it increasingly difficult for the team to figure out what is causing the unique problem. The team is forced to use some unusual methods to get him to cooperate with their necessary testing.

Meanwhile, when House refuses to make an appearance in the clinic, Cuddy takes an unconventional approach to force House to make up the time with a very particular patient (guest star Carl Reiner).

After the talked-about sex scene between House and Cuddy, there will still be more into their complicated relationship. Lisa Edelstein who plays Cuddy gave a nod in a press conference over the weekend on the question whether the relationship will change in the finale.