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Open Targets Workshop

28 March 2019

EMBL-EBI

Open Targets Workshophttps://www.ebi.ac.uk/training/events/2019/introduction-rna-seq-and-functional-interpretationhttps://tess.elixir-europe.org/events/open-targets-workshop-55d54e1b-0a19-4e14-9719-6df0ad7054b9In this workshop, we introduce Open Targets and its underlying projects for data integration for access and visualisation of biological data in drug target identification and discovery.2019-03-28 09:00:00 UTC2019-03-28 00:00:00 UTCEMBL-EBI, EMBL-EBIEMBL-EBIEMBL-EBI[][][]workshops_and_courses[]Open Targets

Open Targets Genetics at ESHG

15 June 2019

Sweden

Open Targets Genetics at ESHGhttps://2019.eshg.org/index.php/programme/saturday/https://tess.elixir-europe.org/events/workshop-at-eshgIn this workshop, we will introduce Open Targets Genetics Portal as part of the Open Targets ecosystem, highlighting variant-centric statistical evidence for prioritizing candidate causal variants at trait-associated loci, and identifying potential drug targets. We will present POSTGAP, a pipeline which merges genetic associations curated from literature with functional genomics, epigenetic and expression data (e.g., eQTL, promoter capture Hi-C, DNase hypersensitivity sites, regulatory elements) to resolve association signals at a locus and link each variant to its target gene(s) using a single evidence score. The portal also incorporates pre-computed fine-mapping at trait-associated loci across hundreds of UK Biobank phenotypes as well as cross-trait colocalization, furthering drug repurposing opportunities. This workshop will enable you to effectively use Open Targets Genetics to gain biological insight, prioritize genes, and inform target decision-making. Intended Audience: Attendees interested in the translational application of genetics and genomics with an emphasis on the identification of target genes of trait-associated loci, drug target identification, prioritisation and repurposing. Participants should bring their laptops for exploration of the Open Targets Genetics Portal in situ.2019-06-15 09:00:00 UTC2019-06-15 00:00:00 UTCGothenburg, SwedenGothenburgSweden[][][]workshops_and_courses[]Open Targets