The A-10 appears in the campaign missions "Iron Lady" and "Scorched Earth", in which a SOFLAM is available to call in strafing runs. Killing nine enemies with the A-10 will award the achievement/trophy Nein.

The A-10 is a cut pointstreak of Call of Duty: Modern Warfare 3. In game files, it is possible to find several unused quotes from team announcers, indicating that the A-10 Thunderbolt II was planned to appear in multiplayer. In the Wii version, the pointstreak is accessible via modding.

The A-10 returns in Call of Duty: Black Ops II as a Scorestreak reward named "Warthog" that executes strafing runs, using its 30mm cannon and rocket pods, around the map multiple times. Upon being called in, the Warthog will perform two to four strafing runs, attacking enemy players within its line of sight. Although difficult to accomplish, it is possible to shoot it down. It has two flares, needing three rockets or Black Hats to destroy.

The A-10 is available in multiplayer. It later appears as the Air Superiority pointstreak. The A-10 also appears on the map Collision as a Field Order reward, the A-10 Strafe. However, there is also a cut streak with the Thunderbolt, the A-10, with audio files in the game.