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Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:query proteins and first shell of interactors

white nodes:second shell of interactors

Node Content

empty nodes:proteins of unknown 3D structure

filled nodes:some 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

miaB

Hypothetical protein; Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (462 aa)

Predicted Functional Partners:

miaA

Hypothetical protein; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (310 aa)

0.751

hemE

Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (355 aa)

0.663

mnmE

tRNA modification GTPase TrmE; Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (454 aa)

0.635

mnmA

tRNA-specific 2-thiouridylase MnmA; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (384 aa)

0.621

guaA

GMP synthase; Catalyzes the synthesis of GMP from XMP (519 aa)

0.586

UMN179_01293

Coproporphyrinogen III oxidase (378 aa)

0.573

iscS

Cysteine desulfurase; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins (404 aa)

0.555

ttcA

C32 tRNA thiolase; Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (306 aa)

0.551

thiI

Thiamine biosynthesis protein ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (487 aa)

a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1

node2

node1 accession

node2 accession

node1 annotation

node2 annotation

score

UMN179_01293

hemE

UMN179_01293

UMN179_00884

Coproporphyrinogen III oxidase

Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III

0.988

UMN179_01293

miaB

UMN179_01293

UMN179_00448

Coproporphyrinogen III oxidase

Hypothetical protein; Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine

0.573

UMN179_02422

guaA

UMN179_02422

UMN179_02420

Inosine 5’-monophosphate dehydrogenase

GMP synthase; Catalyzes the synthesis of GMP from XMP

0.999

UMN179_02422

iscS

UMN179_02422

UMN179_01785

Inosine 5’-monophosphate dehydrogenase

Cysteine desulfurase; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins

0.796

UMN179_02422

miaA

UMN179_02422

UMN179_01961

Inosine 5’-monophosphate dehydrogenase

Hypothetical protein; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)

0.699

UMN179_02422

miaB

UMN179_02422

UMN179_00448

Inosine 5’-monophosphate dehydrogenase

Hypothetical protein; Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine

0.540

UMN179_02422

ttcA

UMN179_02422

UMN179_02457

Inosine 5’-monophosphate dehydrogenase

C32 tRNA thiolase; Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32)

0.841

guaA

UMN179_02422

UMN179_02420

UMN179_02422

GMP synthase; Catalyzes the synthesis of GMP from XMP

Inosine 5’-monophosphate dehydrogenase

0.999

guaA

hemE

UMN179_02420

UMN179_00884

GMP synthase; Catalyzes the synthesis of GMP from XMP

Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III

0.515

guaA

iscS

UMN179_02420

UMN179_01785

GMP synthase; Catalyzes the synthesis of GMP from XMP

Cysteine desulfurase; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins

0.531

guaA

miaB

UMN179_02420

UMN179_00448

GMP synthase; Catalyzes the synthesis of GMP from XMP

Hypothetical protein; Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine

0.586

guaA

thiI

UMN179_02420

UMN179_00022

GMP synthase; Catalyzes the synthesis of GMP from XMP

Thiamine biosynthesis protein ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS

0.769

guaA

ttcA

UMN179_02420

UMN179_02457

GMP synthase; Catalyzes the synthesis of GMP from XMP

C32 tRNA thiolase; Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32)

0.830

hemE

UMN179_01293

UMN179_00884

UMN179_01293

Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III

Coproporphyrinogen III oxidase

0.988

hemE

guaA

UMN179_00884

UMN179_02420

Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III

GMP synthase; Catalyzes the synthesis of GMP from XMP

0.515

hemE

iscS

UMN179_00884

UMN179_01785

Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III

Cysteine desulfurase; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins

0.409

hemE

miaB

UMN179_00884

UMN179_00448

Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III

Hypothetical protein; Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine

0.663

iscS

UMN179_02422

UMN179_01785

UMN179_02422

Cysteine desulfurase; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins

Inosine 5’-monophosphate dehydrogenase

0.796

iscS

guaA

UMN179_01785

UMN179_02420

Cysteine desulfurase; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins

GMP synthase; Catalyzes the synthesis of GMP from XMP

0.531

iscS

hemE

UMN179_01785

UMN179_00884

Cysteine desulfurase; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins

Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III

0.409

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Network Stats

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Functional enrichments in your networkNote: some enrichments may be expected here (why?)

Enrichment analysis is still ongoing, please wait ...

Statistical background

For the above enrichment analysis, the following statistical background is assumed: