All about: Mephyton

What is Mephyton (phytonadione)?

Phytonadione is a man-made form of vitamin K. Phytonadione is important in the production
of substances that cause the blood to clot.

Phytonadione is used to treat vitamin K deficiency and to treat certain bleeding or blood
clotting problems.

Phytonadione may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about Mephyton (phytonadione)?

Tell your doctor and dentist that you are taking phytonadione before having any type of
surgery.

What should I discuss with my healthcare provider before taking
Mephyton (phytonadione)?

Phytonadione may affect other medical conditions or treatments. Talk to your doctor before
taking phytonadione if you have other health problems or conditions, or if you take other
medications.

Phytonadione is in the FDA pregnancy category C. This means that it is not known
whether phytonadione will be harmful to an unborn baby. Do no not take phytonadione without first
talking to your doctor if you are pregnant or could become pregnant during treatment.
It is not known whether phytonadione passes into breast milk and if it will affect a
nursing baby. Do not take this medication without first talking to your doctor if you are
breast-feeding a baby.

How should I take Mephyton (phytonadione)?

Take phytonadione exactly as directed by your doctor. If you do not understand these
directions, ask your pharmacist, nurse, or doctor to explain them to you.

Take each oral dose with a full glass of water.

Injectable forms of phytonadione are usually administered by a healthcare professional. If
you are injecting phytonadione at home, your doctor or nurse will give you detailed instructions
regarding preparation, administration, and storage of the medication.

Do not take more phytonadione than is prescribed.

It is important to take phytonadione regularly to get the most benefit.

Your doctor may want you to have blood tests or other medical evaluations during treatment
with phytonadione to monitor progress and side effects.

Store phytonadione at room temperature away from moisture and heat. Protect
phytonadione from light, as light decreases the effectiveness of the medication.

What happens if I miss a dose?

Contact your doctor if you miss a dose of this medication.

What happens if I overdose?

Seek emergency medical attention if an overdose is suspected.

Symptoms of a phytonadione overdose are not known.

What should I avoid while taking Mephyton (phytonadione)?

Tell your doctor and dentist that you are taking phytonadione before having any type of
surgery.

Mephyton (phytonadione) side effects

Seek emergency medical attention or contact your doctor immediately if you experience
any serious side effects from phytonadione such as:

an allergic reaction (difficulty breathing; closing of the throat;
swelling of the lips, tongue, or face; or hives);

dizziness;

fast or irregular heartbeats; or

increased sweating.

Other less serious side effects may be more likely to occur. Continue to
use phytonadione and talk to your doctor if you experience

flushing of the face;

an unusual taste in the mouth; or

pain or irritation at the injection site (injectable form).

Side effects other than those listed here may also occur. Talk to your
doctor about any side effect that is unusual or that is especially bothersome.

What other drugs will affect Mephyton (phytonadione)?

Before taking phytonadione, tell your doctor about all other medicines you are taking,
especially any of the following:

You may not be able to take phytonadione, or you may require a dosage
adjustment or special monitoring during treatment.

Medications other than those listed here may also interact with phytonadione. Tell your
doctor about all other prescription and over-the-counter medicines that you take, including vitamins,
minerals, and herbal products.

Where can I get more information?

Your pharmacist has more information about phytonadione written for health professionals
that you may read.

What does my medication look like?

Phytonadione is available with a prescription under the brand names Mephyton and
Aquamephyton in oral tablet and injectable formulations. Ask your pharmacist any questions you
have about this medication, especially if it is new to you.

Mephyton 5 mg-yellow, round tablets

Aquamephyton 1 mg/0.5 mL-yellow liquid for injection

Aquamephyton 10 mg/1 mL-yellow liquid for injection

Remember, keep this and all other medicines out of the reach of children, never share your
medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date,
and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has
been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses
outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs,
diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare
practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the
expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in
no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum
does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The
information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic
reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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