The same-sex marriage movement lost its first major case in a federal appeals court Thursday after a lengthy string of victories, creating a split among the nation's circuit courts that virtually guarantees review by the U.S. Supreme Court.

The 2-1 ruling from the Cincinnati-based 6th U.S. Circuit Court of Appeals reversed lower court rulings that had struck down gay marriage bans in Michigan, Ohio, Kentucky and Tennessee.

Less than a day after a stinging defeat that saw her party lose control of the Senate, Sen. Amy Klobuchar, D-Minn., could still find policy priorities she thinks she can work jointly with Republicans when they take control of the Senate in 2015.

Among them are subjects that have eluded a search for common ground in past years, including trade, hunger and climate change.