Research Conducted Using Data Obtained through Online Communities: Ethical Implications of Methodological Limitations

A Cecile J W JanssensDepartment of Epidemiology, Erasmus University Medical Center Rotterdam, The Netherlands Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia, United States of AmericaPLoS Med 9:e1001328. 2012

..To investigate the extent to which shared genetic factors can explain the clustering of depression among individuals with lower socioeconomic status, and to examine if neuroticism or intelligence are involved in these pathways...

..A detailed Explanation and Elaboration document is published at http://www.plosmedicine.org...

Research Conducted Using Data Obtained through Online Communities: Ethical Implications of Methodological Limitations

A Cecile J W JanssensDepartment of Epidemiology, Erasmus University Medical Center Rotterdam, The Netherlands Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia, United States of AmericaPLoS Med 9:e1001328. 2012

..Insight into morally relevant differences between diseases will assist researchers, healthcare professionals, policy-makers and other stakeholders in the ethical evaluation of personal genome tests...

..There is ongoing debate about whether testing low-risk genes at multiple loci will be useful in clinical care and public health. We investigated the usefulness of multiple genetic testing using simulated data...

The impact of genotype frequencies on the clinical validity of genomic profiling for predicting common chronic diseases

..There is insufficient scientific evidence to conclude that genomic profiles are useful in measuring genetic risk for common diseases or in developing personalized diet and lifestyle recommendations for disease prevention...

Prediction of anxiety and distress following diagnosis of multiple sclerosis: a two-year longitudinal study

..Commercial internet-based companies offer genome-wide scans to predict the risk of common diseases and personalize nutrition and lifestyle recommendations. These risk estimates are updated with every new gene discovery...

Value of the HLA-DRB1 shared epitope for predicting radiographic damage in rheumatoid arthritis depends on the individual patient risk profile

..Genome-wide association (GWA) studies identified multiple new genetic variants that associate with type 2 diabetes. The predictive value of genetic testing for prediction of type 2 diabetes in the general population is unclear...

..Most research on genome-based applications in AD is still in the first phase of the translational research framework, which means that further research is still needed before their implementation can be considered...

..5. In conclusion, Cox proportional hazards models can increase statistical power in cross-sectional genetic association studies, especially in the range of effect estimates that are expected for genetic associations in common diseases...

Angiotensinogen M235T polymorphism and symptoms of depression in a population-based study and a family-based study

..The aim of this paper is to examine the association between the AGT M235T polymorphism and symptoms of depression in two independent populations; a population-based study, and a family-based study...

Patients with Barrett's esophagus perceive their risk of developing esophageal adenocarcinoma as low

Most published research findings are false-but a little replication goes a long way

Ramal MoonesingheNational Office of Public Health Genomics, Coordinating Center for Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of AmericaPLoS Med 4:e28. 2007

Prenatal exposure to the 1944-45 Dutch 'hunger winter' and addiction later in life