During a battle with Conrad Marcus as Venom, Miles Morales' mother, Rio Morales is killed. After seeing this inside Venom's stomach, Miles blasted his way out with a Venom Blast, effectively blasting the symbiote off Conrad.

After Conrad is found, and shot dead by police, Miles retreats to his room to tear his costume apart, not wanting to be Spider-Man anymore.

A year later, Miles has a girlfriend named Kate Bishop who goes to his school. Spider-Woman has tried to make Miles become Spider-Man once more, but fails.