One Hit Kills: This could also affect ally NPCs so be careful with this on mission with allies.

No Poison / Radioactive / Fall Damage: While active you can run into poison areas without any problems. You will also no longer receive radioactive or fall damage.

Perfect Lockpicking & Hacking Skills: Press hotkey and it will set your lockpicking and hacking skills to maximum. It will also create a backup of your original skill values. Once you are done press again to reset your original skill values - DO NOT FORGET THIS STEP! This option is very useful if you temporarily need better lockpicking skills.

Set World Speed: Press hotkey to set world speed to a specific value (two hotkeys for either slowmo or super speed). This is useful if you need to pass a long distance and don't or cannot fast travel. Or just want to pass some time. Press again to reset. Remember you can change the values on the trainer.

Fly Camera: Press hotkey and you can fly around making some cool screenshots or look for something useful.
Press again to switch back to your character.

Selected Character Loyalty: First talk to the character and check your loyalty status. Then press hotkey or use editor. The maximum loyalty is 200 and the minimum loyalty is 0.