Contents

Chemistry

Arylcyclohexylamines are comprised of an amine moiety and an aromatic ring attached to a cyclohexane ring.

Hydrogen atoms around the structure can be substituted for other functional groups to produce drugs of varying potency, affinity, efficacy and half-life.

Pharmacology

Arylcyclohexylamines are believed to produce their effects primarily by antagonism of NMDA receptors.[1]Antagonism of the NMDA receptor confers anesthetic, anticonvulsant, and dissociative effects. Contrary to popular belief, most arylcyclohexylamines do not significantly inhibit re-uptake of dopamine or agonise μ-opioid receptors.