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This paper is concerned with the fatigue behavior of complex, three-dimensional, stress concentrations under multiaxial loadings. Starting from the stress field obtained from a linear elastic analysis and taking advantage of the so-called implicit gradient approximation, an effective stress index connected with the material strength is calculated. Besides, this work summarizes a first investigation into the possibility of applying the implicit gradient approach to real components under both uniaxial and multiaxial loading conditions by introducing an appropriate multiaxial criterion into the implicit gradient framework. The damage evaluation is obtained by analyzing the loading path on the 5-dimensinal deviatoric Euclidean space.