Abstract

Dopamine is an important neurotransmitter in central nervous system as an indicator of several neurological disorders such as Parkinson’s disease. The accurate monitoring of dopamine level is the significant factor for prevention and diagnosis of various neurological disorders. Commonly used metal nanoparticles such as gold and platinum for electrochemical dopamine detection have limitations such as low sensitivity and low linearity at low concentration of dopamine. In this study, for the first time, silver encapsulated MoS2 (Ag/MoS2) hybrid nanoparticle was developed and spin-coated on the indium tin oxide (ITO) electrode to enhance the electrochemical signal for dopamine detection. This newly developed biosensor induced the well-orientation of Ag/MoS2 hybrid nanoparticle, high reproducibility and high sensitivity at low dopamine concentrations compared to the previously reported biosensors. Thus, our newly fabricated electrochemical biosensor composed of Ag/MoS2 hybrid nanoparticle can be applied to monitor the level of dopamine accurately for diagnosis and prevention of various neurological disorders with the electrochemical signal enhancement.