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Although platinum-based chemotherapy is currently standard of care in NSCLC, data suggest that certain individual tumors may have inherent resistance to platinum compounds. Excision repair cross-complementation group.

Xeroderma Pigmentosum (XP) is a disorder caused by deficiency of genes involved in NER. Cells derived from XP patients are exquisitely sensitive to cisplatin [30]. In addition, the favorable response of testicular cancer to cisplatin was associated with low levels of XP complementation group A (XPA) and excision repair cross-complementation group.

Both ends of the break are first bound by the Ku70/Ku80 heterodimer, which then recruits the catalytic subunit of the DNA dependent protein kinase (DNA-PKcs) [2]. If necessary, the ends can be trimmed by nucleases (such as Artemis) or filled in by DNA polymerases (such as Polµ or Pol?) to create compatible ends [3]. Finally, the ligation complex, consisting of DNA ligase IV, X-ray cross-complementation group.

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