To evaluate the virological efficacy and safety at week 48 of 2 regimens atazanavir/ritonavir (ATZ/r) 300/100 mg or darunavir/ritonavir (DRV/r) 800/100 mg, each in combination with a fixed-dose of tenofovir/emtracitabine in HIV-1 treatment-naïve subjects with CD4 counts below 200 µL

At the end of the study, in a central lab, we will measure some inflammation and activation markers (CD69, HLA-DR, CD38, annexine V, IL-6, CD14s, IL-7 plasma) of lymphocytes CD4 and CD8(with the plasmatheque collected during the study)

The patient included in this Group 1 will receive their first antiretroviral regimen included : ATV + TDF/FTC (or Abacavir/Lamivudine, [ABC/3TC], if contre indicated of TDF/FTC) The dose : atazanavir/ritonavir 300/100mg/day and TDF/FTC 245 /200 mg day, 3 pills once a day, during 48 weeks during a meal

Drug: ATAZANAVIR

The patient included will receive their first antiretroviral regimen included the atazanavir treatment in combination with 2 others molecules

Other Name: REYATAZ

Experimental: DARUNAVIR

The patients included in this Group 2 will receive their first antiretroviral regimen included Group 2 : DRV+ TDF/FTC (or ABC/3TC if contre-indicated of TDF/FTC) The dose : darunavir/ritonavir 800/100mg/day and TDF/FTC 245 /200 mg day, 4 pills once a day, during 48 weeks during a meal

Drug: DARUNAVIR

The patient included will receive their first antiretroviral regimen included the darunavir treatment in combination with 2 others molecules

Patients in the opinion of the investigator that are unlikley to be able to follow study instructions

Any subject unable to take antiretroviral medication for whatever reason

Any subject taking a treatment or medication that is contraindicated when co-administered with any arm or drug in the treatment

Contacts and Locations

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Please refer to this study by its ClinicalTrials.gov identifier: NCT01928407