Russell Brand's first interview on Jonathan Ross.Crispin Glover on Letterman (though Letterman was a douche).The How I Met Your Mother cast on the Megan Mullally Show.Kelka with SloGreenX.Cast and Crew of Buffy on Academy of Television Arts and Sciences Panel Discussion.

_________________Yeah it’s two R’s, h-o-r-r... yeah, right."So something ripped him open and ate out his insides?" "Like an oreo cookie! ... well, except for, you know, without the chocolaty cookie goodness."DON'T WARN THE TADPOLES!

Harmony Korine on Letterman: http://www.youtube.com/watch?v=Q4JIkmzWfn0If you watch the Letterman interview from two years later, it's even funnier to see the difference. He's not allowed back anymore because he was involved in an altercation with Meryl Streep.

Loved Marc Maron interviewing Louis CK on what the fizzle. Also Maron's interview of Carlos Mencia with the follow-up interview. He interviewed Mencia, and then talked to a bunch of comedians about Mencia stealing jokes and genrally being no-good, and then called him to ask about the shiitake he'd heard, and Mencia drove from the airport straight to Maron's to talk about people's accusations. I didn't like what the fizzle at first, but now that I've listened to more, he's actually a great interviewer.

In a completely different direction, I also love [url]this interview with Keri Smith[/url].

i can't believe no one's mentioned Katie Couric interviewing Sarah Palin. I mean, that was the best shiitake ever, I was cracking up and screaming, "YES!" the whole time, because I was genuinely afraid that she might actually become vice president before the election, and after that interview I couldn't imagine enough people could possibly still be convinced she isn't an idiot to make that happen.

I don't know if this would really count, because it's not an interview per se, but the segment on This American Life from July of 2008 that Dan Savage was on talking about his son being against gay marriage initially was amazing.