Light Bullets/Slow Powders

I have been loading with 168gr.TSX and H1000 powder and it has been a very accurate load averaging around 3195-3205 fps.After playing with the Quick Load program,I see that it predicts more velocity at the same pressure as the above ,if I substituted Retumbo(+2grs.).Assuming that I can equal the accuracy of the H-1000 load with an increase in velocity of 50fps. is there any reason to not go with the Retumbo?Am I overlooking safe and sound reloading practices?By the way,the caliber is .300Win.mag.
Could I load a 150gr.bullet,safely with the Retumbo?QL shows around 3400fps. with the 150 Accubond.Again assuming good consistant accuracy.Trying to find the best Texas whitetail load out to 400yds.
Thanks for any comments!
Jimmy

Why go with the 150? The 168 TSX is perfect to 400 from the WM. I prefer Re22 in 300 Win, but a good load is a good load, no matter the powder. Sounds like you're ready to hunt. Stick with the TSX. The 168 is my favorite in my 30 cal rifles.

Jimmy--don't worry at all about getting that 50 fps more. Just go for accuracy at a reasonable speed. If you have quickload you also got "quicktarget" when you bought the quickload. (at least I did). run the extra 50 fps past quicktarget and you will see it is virtually meaningless to the flight path of the bullet. If you can get 3/4 moa out to 400 yds you are set to kill reagardless of even 100 fps.
Play around with some "flight paths" on quick target. Often you get get the same trajectory out of a 100 fps slower load just by raising the "midpoint" of the flight path ever so slightly. I have a 300 wby that is somewhat finicky--I could care less if my load winds up being 3200 fps or 3300 fps or 3350 fps--it's accuracy that will put the meat on the dinner table. The flight path will hardly vary for me with these speeds. I've found the quicktarget program almost as much fun to work with as quickload itself. (It also helps me calibrate my burris ballistic plex and several other custom reticle scopes for different calibers.)

I have had good velocity and accuracy with RL-22,but find it very sensitive to cold temperatures,so have been loading the Hodgdon Extreme powders with good results.I really like the performance of the TSX,but was wanting more blood and guts results from the wound channel.If I don't anchor the deer on the spot and they run,it would be very difficult to track.The TSX doesn't open much of a wound channel.These are the reasons that I was thinking about the 150 Accubond.
Jimmy

Try the H-4831 or H-4831SC. Both are nearly identical to Rl-22 in burn rate and very temp resistant.

I have never noticed a real problem with Rl-22 in cold weather but I use nothing but the hot Fed-215 magnum primers for all my magnum loads. This may solve that problem but with the two Hodgdon powders being so close in performance to RL-22, just go with those!