Tag Archives: epic

Last Saturday we took a look at some of the most-read Singularity Hub articles from 2019. This week, we’re featuring some of our favorite articles from the last year. As opposed to short pieces about what’s happening, these are long reads about why it matters and what’s coming next. Some of them make the news while others frame the news, go deep on big ideas, go behind the scenes, or explore the human side of technological progress.

We hope you find them as fascinating, inspiring, and illuminating as we did.

DeepMind and Google: The Battle to Control Artificial Intelligence
Hal Hodson | 1843
“[DeepMind cofounder and CEO Demis] Hassabis thought DeepMind would be a hybrid: it would have the drive of a startup, the brains of the greatest universities, and the deep pockets of one of the world’s most valuable companies. Every element was in place to hasten the arrival of [artificial general intelligence] and solve the causes of human misery.”

The Most Powerful Person in Silicon Valley
Katrina Brooker | Fast Company
“Billionaire Masayoshi Son—not Elon Musk, Jeff Bezos, or Mark Zuckerberg—has the most audacious vision for an AI-powered utopia where machines control how we live. And he’s spending hundreds of billions of dollars to realize it. Are you ready to live in Masa World?”

AR Will Spark the Next Big Tech Platform—Call It Mirrorworld
Kevin Kelly | Wired
“Eventually this melded world will be the size of our planet. It will be humanity’s greatest achievement, creating new levels of wealth, new social problems, and uncountable opportunities for billions of people. There are no experts yet to make this world; you are not late.”

Behind the Scenes of a Radical New Cancer Cure
Ilana Yurkiewicz | Undark
“I remember the first time I watched a patient get his Day 0 infusion. It felt anti-climactic. The entire process took about 15 minutes. The CAR-T cells are invisible to the naked eye, housed in a small plastic bag containing clear liquid. ‘That’s it?’ my patient asked when the nurse said it was over. The infusion part is easy. The hard part is everything that comes next.”

The Promise and Price of Cellular Therapies
Siddhartha Mukherjee | The New Yorker
“We like to imagine medical revolutions as, well, revolutionary—propelled forward through leaps of genius and technological innovation. But they are also evolutionary, nudged forward through the optimization of design and manufacture.”

Impossible Foods’ Rising Empire of Almost Meat
Chris Ip | Engadget
“Impossible says it wants to ultimately create a parallel universe of ersatz animal products from steak to eggs. …Yet as Impossible ventures deeper into the culinary uncanny valley, it also needs society to discard a fundamental cultural idea that dates back millennia and accept a new truth: Meat doesn’t have to come from animals.”

Inside the Amazon Warehouse Where Humans and Machines Become One
Matt Simon | Wired
“Seen from above, the scale of the system is dizzying. My robot, a little orange slab known as a ‘drive’ (or more formally and mythically, Pegasus), is just one of hundreds of its kind swarming a 125,000-square-foot ‘field’ pockmarked with chutes. It’s a symphony of electric whirring, with robots pausing for one another at intersections and delivering their packages to the slides.”

Boston Dynamics’ Robots Are Preparing to Leave the Lab—Is the World Ready?
James Vincent | The Verge
“After decades of kicking machines in parking lots, the company is set to launch its first ever commercial bot later this year: the quadrupedal Spot. It’s a crucial test for a company that’s spent decades pursuing long-sighted R&D. And more importantly, the success—or failure—of Spot will tell us a lot about our own robot future. Are we ready for machines to walk among us?”

I Cut the ‘Big Five’ Tech Giants From My Life. It Was Hell
Kashmir Hill | Gizmodo
“Critics of the big tech companies are often told, ‘If you don’t like the company, don’t use its products.’ I did this experiment to find out if that is possible, and I found out that it’s not—with the exception of Apple. …These companies are unavoidable because they control internet infrastructure, online commerce, and information flows.”

Why I (Still) Love Tech: In Defense of a Difficult Industry
Paul Ford | Wired
“The mysteries of software caught my eye when I was a boy, and I still see it with the same wonder, even though I’m now an adult. Proudshamed, yes, but I still love it, the mess of it, the code and toolkits, down to the pixels and the processors, and up to the buses and bridges. I love the whole made world. But I can’t deny that the miracle is over, and that there is an unbelievable amount of work left for us to do.”

The Peculiar Blindness of Experts
David Epstein | The Atlantic
“In business, esteemed (and lavishly compensated) forecasters routinely are wildly wrong in their predictions of everything from the next stock-market correction to the next housing boom. Reliable insight into the future is possible, however. It just requires a style of thinking that’s uncommon among experts who are certain that their deep knowledge has granted them a special grasp of what is to come.”

The Most Controversial Tree in the World
Rowan Jacobson | Pacific Standard
“…we are all GMOs, the beneficiaries of freakishly unlikely genetic mash-ups, and the real Island of Dr. Moreau is that blue-green botanical garden positioned third from the sun. Rather than changing the nature of nature, as I once thought, this might just be the very nature of nature.”

How an Augmented Reality Game Escalated Into Real-World Spy Warfare
Elizabeth Ballou | Vice
“In Ingress, players accept that every park and train station could be the site of an epic showdown, but that’s only the first step. The magic happens when other people accept that, too. When players feel like that magic is real, there are few limits to what they’ll do or where they’ll go for the sake of the game. ”

The Shady Cryptocurrency Boom on the Post-Soviet Frontier
Hannah Lucinda Smith | Wired
“…although the tourists won’t guess it as they stand at Kuchurgan’s gates, admiring how the evening light reflects off the silver plaque of Lenin, this plant is pumping out juice to a modern-day gold rush: a cryptocurrency boom that is underway all across the former Soviet Union, from the battlefields of eastern Ukraine to time-warp enclaves like Transnistria and freshly annexed Crimea.”

Scientists Are Totally Rethinking Animal Cognition
Ross Andersen | The Atlantic
“This idea that animals are conscious was long unpopular in the West, but it has lately found favor among scientists who study animal cognition. …For many scientists, the resonant mystery is no longer which animals are conscious, but which are not.”

I Wrote This on a 30-Year-Old Computer
Ian Bogost | The Atlantic
“[Back then] computing was an accompaniment to life, rather than the sieve through which all ideas and activities must filter. That makes using this 30-year-old device a surprising joy, one worth longing for on behalf of what it was at the time, rather than for the future it inaugurated.”

Last night, way past midnight, I stumbled onto my porch blindly grasping for my keys after a hellish day of international travel. Lights were low, I was half-asleep, yet my hand grabbed the keychain, found the lock, and opened the door.

If you’re rolling your eyes—yeah, it’s not exactly an epic feat for a human. Thanks to the intricate wiring between our brain and millions of sensors dotted on—and inside—our skin, we know exactly where our hand is in space and what it’s touching without needing visual confirmation. But this combined sense of the internal and the external is completely lost to robots, which generally rely on computer vision or surface mechanosensors to track their movements and their interaction with the outside world. It’s not always a winning strategy.

What if, instead, we could give robots an artificial nervous system?

This month, a team led by Dr. Rob Shepard at Cornell University did just that, with a seriously clever twist. Rather than mimicking the electric signals in our nervous system, his team turned to light. By embedding optical fibers inside a 3D printed stretchable material, the team engineered an “optical lace” that can detect changes in pressure less than a fraction of a pound, and pinpoint the location to a spot half the width of a tiny needle.

The invention isn’t just an artificial skin. Instead, the delicate fibers can be distributed both inside a robot and on its surface, giving it both a sense of tactile touch and—most importantly—an idea of its own body position in space. Optical lace isn’t a superficial coating of mechanical sensors; it’s an entire platform that may finally endow robots with nerve-like networks throughout the body.

Eventually, engineers hope to use this fleshy, washable material to coat the sharp, cold metal interior of current robots, transforming C-3PO more into the human-like hosts of Westworld. Robots with a “bodily” sense could act as better caretakers for the elderly, said Shepard, because they can assist fragile people without inadvertently bruising or otherwise harming them. The results were published in Science Robotics.

An Unconventional Marriage
The optical lace is especially creative because it marries two contrasting ideas: one biological-inspired, the other wholly alien.

The overarching idea for optical lace is based on the animal kingdom. Through sight, hearing, smell, taste, touch, and other senses, we’re able to interpret the outside world—something scientists call exteroception. Thanks to our nervous system, we perform these computations subconsciously, allowing us to constantly “perceive” what’s going on around us.

Our other perception is purely internal. Proprioception (sorry, it’s not called “inception” though it should be) is how we know where our body parts are in space without having to look at them, which lets us perform complex tasks when blind. Although less intuitive than exteroception, proprioception also relies on stretching and other deformations within the muscles and tendons and receptors under the skin, which generate electrical currents that shoot up into the brain for further interpretation.

In other words, in theory it’s possible to recreate both perceptions with a single information-carrying system.

Here’s where the alien factor comes in. Rather than using electrical properties, the team turned to light as their data carrier. They had good reason. “Compared with electricity, light carries information faster and with higher data densities,” the team explained. Light can also transmit in multiple directions simultaneously, and is less susceptible to electromagnetic interference. Although optical nervous systems don’t exist in the biological world, the team decided to improve on Mother Nature and give it a shot.

Optical Lace
The construction starts with engineering a “sheath” for the optical nerve fibers. The team first used an elastic polyurethane—a synthetic material used in foam cushioning, for example—to make a lattice structure filled with large pores, somewhat like a lattice pie crust. Thanks to rapid, high-resolution 3D printing, the scaffold can have different stiffness from top to bottom. To increase sensitivity to the outside world, the team made the top of the lattice soft and pliable, to better transfer force to mechanical sensors. In contrast, the “deeper” regions held their structure better, and kept their structure under pressure.

Now the fun part. The team next threaded stretchable “light guides” into the scaffold. These fibers transmit photons, and are illuminated with a blue LED light. One, the input light guide, ran horizontally across the soft top part of the scaffold. Others ran perpendicular to the input in a “U” shape, going from more surface regions to deeper ones. These are the output guides. The architecture loosely resembles the wiring in our skin and flesh.

Normally, the output guides are separated from the input by a small air gap. When pressed down, the input light fiber distorts slightly, and if the pressure is high enough, it contacts one of the output guides. This causes light from the input fiber to “leak” to the output one, so that it lights up—the stronger the pressure, the brighter the output.

“When the structure deforms, you have contact between the input line and the output lines, and the light jumps into these output loops in the structure, so you can tell where the contact is happening,” said study author Patricia Xu. “The intensity of this determines the intensity of the deformation itself.”

Double Perception
As a proof-of-concept for proprioception, the team made a cylindrical lace with one input and 12 output channels. They varied the stiffness of the scaffold along the cylinder, and by pressing down at different points, were able to calculate how much each part stretched and deformed—a prominent precursor to knowing where different regions of the structure are moving in space. It’s a very rudimentary sort of proprioception, but one that will become more sophisticated with increasing numbers of strategically-placed mechanosensors.

The test for exteroception was a whole lot stranger. Here, the team engineered another optical lace with 15 output channels and turned it into a squishy piano. When pressed down, an Arduino microcontroller translated light output signals into sound based on the position of each touch. The stronger the pressure, the louder the volume. While not a musical masterpiece, the demo proved their point: the optical lace faithfully reported the strength and location of each touch.

A More Efficient Robot
Although remarkably novel, the optical lace isn’t yet ready for prime time. One problem is scalability: because of light loss, the material is limited to a certain size. However, rather than coating an entire robot, it may help to add optical lace to body parts where perception is critical—for example, fingertips and hands.

The team sees plenty of potential to keep developing the artificial flesh. Depending on particular needs, both the light guides and scaffold can be modified for sensitivity, spatial resolution, and accuracy. Multiple optical fibers that measure for different aspects—pressure, pain, temperature—can potentially be embedded in the same region, giving robots a multitude of senses.

In this way, we hope to reduce the number of electronics and combine signals from multiple sensors without losing information, the authors said. By taking inspiration from biological networks, it may even be possible to use various inputs through an optical lace to control how the robot behaves, closing the loop from sensation to action.

Image Credit: Cornell Organic Robotics Lab. A flexible, porous lattice structure is threaded with stretchable optical fibers containing more than a dozen mechanosensors and attached to an LED light. When the lattice structure is pressed, the sensors pinpoint changes in the photon flow. Continue reading →

The Tunnel Circuit of the DARPA Subterranean Challenge starts later this week at the NIOSH research mine just outside of Pittsburgh, Pennsylvania. From 15-22 August, 11 teams will send robots into a mine that they've never seen before, with the goal of making maps and locating items. All DARPA SubT events involve tunnels of one sort or another, but in this case, the “Tunnel Circuit” refers to mines as opposed to urban underground areas or natural caves. This month’s challenge is the first of three discrete events leading up to a huge final event in August of 2021.

While the Tunnel Circuit competition will be closed to the public, and media are only allowed access for a single day (which we'll be at, of course), DARPA has provided a substantial amount of information about what teams will be able to expect. We also have details from the SubT Integration Exercise, called STIX, which was a completely closed event that took place back in April. STIX was aimed at giving some teams (and DARPA) a chance to practice in a real tunnel environment.

For more general background on SubT, here are some articles to get you all caught up:

SubT: The Next DARPA Challenge for Robotics

Q&A with DARPA Program Manager Tim Chung

Meet The First Nine Teams

It makes sense to take a closer look at what happened at April's STIX exercise, because it is (probably) very similar to what teams will experience in the upcoming Tunnel Circuit. STIX took place at Edgar Experimental Mine in Colorado, and while no two mines are the same (and many are very, very different), there are enough similarities for STIX to have been a valuable experience for teams. Here's an overview video of the exercise from DARPA:

DARPA has also put together a much more detailed walkthrough of the STIX mine exercise, which gives you a sense of just how vast, complicated, and (frankly) challenging for robots the mine environment is:

So, that's the kind of thing that teams had to deal with back in April. Since the event was an exercise, rather than a competition, DARPA didn't really keep score, and wouldn't comment on the performance of individual teams. We've been trolling YouTube for STIX footage, though, to get a sense of how things went, and we found a few interesting videos.

Here's a nice overview from Team CERBERUS, which used drones plus an ANYmal quadruped:

Team CTU-CRAS also used drones, along with a tracked robot:

Team Robotika was brave enough to post video of a “fatal failure” experienced by its wheeled robot; the poor little bot gets rescued at about 7:00 in case you get worried:

So that was STIX. But what about the Tunnel Circuit competition this week? Here's a course preview video from DARPA:

It sort of looks like the NIOSH mine might be a bit less dusty than the Edgar mine was, but it could also be wetter and muddier. It’s hard to tell, because we’re just getting a few snapshots of what’s probably an enormous area with kilometers of tunnels that the robots will have to explore. But DARPA has promised “constrained passages, sharp turns, large drops/climbs, inclines, steps, ladders, and mud, sand, and/or water.” Combine that with the serious challenge to communications imposed by the mine itself, and robots will have to be both physically capable, and almost entirely autonomous. Which is, of course, exactly what DARPA is looking to test with this challenge.

Lastly, we had a chance to catch up with Tim Chung, Program Manager for the Subterranean Challenge at DARPA, and ask him a few brief questions about STIX and what we have to look forward to this week.

IEEE Spectrum: How did STIX go?

Tim Chung: It was a lot of fun! I think it gave a lot of the teams a great opportunity to really get a taste of what these types of real world environments look like, and also what DARPA has in store for them in the SubT Challenge. STIX I saw as an experiment—a learning experience for all the teams involved (as well as the DARPA team) so that we can continue our calibration.

What do you think teams took away from STIX, and what do you think DARPA took away from STIX?

I think the thing that teams took away was that, when DARPA hosts a challenge, we have very audacious visions for what the art of the possible is. And that's what we want—in my mind, the purpose of a DARPA Grand Challenge is to provide that inspiration of, ‘Holy cow, someone thinks we can do this!’ So I do think the teams walked away with a better understanding of what DARPA's vision is for the capabilities we're seeking in the SubT Challenge, and hopefully walked away with a better understanding of the technical, physical, even maybe mental challenges of doing this in the wild— which will all roll back into how they think about the problem, and how they develop their systems.

This was a collaborative exercise, so the DARPA field team was out there interacting with the other engineers, figuring out what their strengths and weaknesses and needs might be, and even understanding how to handle the robots themselves. That will help [strengthen] connections between these university teams and DARPA going forward. Across the board, I think that collaborative spirit is something we really wish to encourage, and something that the DARPA folks were able to take away.

What do we have to look forward to during the Tunnel Circuit?

The vision here is that the Tunnel Circuit is representative of one of the three subterranean subdomains, along with urban and cave. Characteristics of all of these three subdomains will be mashed together in an epic final course, so that teams will have to face hints of tunnel once again in that final event.

Without giving too much away, the NIOSH mine will be similar to the Edgar mine in that it's a human-made environment that supports mining operations and research. But of course, every site is different, and these differences, I think, will provide good opportunities for the teams to shine.

Again, we'll be visiting the NIOSH mine in Pennsylvania during the Tunnel Circuit and will post as much as we can from there. But if you’re an actual participant in the Subterranean Challenge, please tweet me @BotJunkie so that I can follow and help share live updates.

In many industries, a decade is barely enough time to cause dramatic change unless something disruptive comes along—a new technology, business model, or service design. The space industry has recently been enjoying all three.

But 10 years ago, none of those innovations were guaranteed. In fact, on Sept. 28, 2008, an entire company watched and hoped as their flagship product attempted a final launch after three failures. With cash running low, this was the last shot. Over 21,000 kilograms of kerosene and liquid oxygen ignited and powered two booster stages off the launchpad.

This first official picture of the Soviet satellite Sputnik I was issued in Moscow Oct. 9, 1957. The satellite measured 1 foot, 11 inches and weighed 184 pounds. The Space Age began as the Soviet Union launched Sputnik, the first man-made satellite, into orbit, on Oct. 4, 1957.AP Photo/TASS
When that Falcon 1 rocket successfully reached orbit and the company secured a subsequent contract with NASA, SpaceX had survived its ‘startup dip’. That milestone, the first privately developed liquid-fueled rocket to reach orbit, ignited a new space industry that is changing our world, on this planet and beyond. What has happened in the intervening years, and what does it mean going forward?

While scientists are busy developing new technologies that address the countless technical problems of space, there is another segment of researchers, including myself, studying the business angle and the operations issues facing this new industry. In a recent paper, my colleague Christopher Tang and I investigate the questions firms need to answer in order to create a sustainable space industry and make it possible for humans to establish extraterrestrial bases, mine asteroids and extend space travel—all while governments play an increasingly smaller role in funding space enterprises. We believe these business solutions may hold the less-glamorous key to unlocking the galaxy.

The New Global Space Industry
When the Soviet Union launched their Sputnik program, putting a satellite in orbit in 1957, they kicked off a race to space fueled by international competition and Cold War fears. The Soviet Union and the United States played the primary roles, stringing together a series of “firsts” for the record books. The first chapter of the space race culminated with Neil Armstrong and Buzz Aldrin’s historic Apollo 11 moon landing which required massive public investment, on the order of US$25.4 billion, almost $200 billion in today’s dollars.

Competition characterized this early portion of space history. Eventually, that evolved into collaboration, with the International Space Station being a stellar example, as governments worked toward shared goals. Now, we’ve entered a new phase—openness—with private, commercial companies leading the way.

The industry for spacecraft and satellite launches is becoming more commercialized, due, in part, to shrinking government budgets. According to a report from the investment firm Space Angels, a record 120 venture capital firms invested over $3.9 billion in private space enterprises last year. The space industry is also becoming global, no longer dominated by the Cold War rivals, the United States and USSR.

In 2018 to date, there have been 72 orbital launches, an average of two per week, from launch pads in China, Russia, India, Japan, French Guinea, New Zealand, and the US.

The uptick in orbital launches of actual rockets as well as spacecraft launches, which includes satellites and probes launched from space, coincides with this openness over the past decade.

More governments, firms and even amateurs engage in various spacecraft launches than ever before. With more entities involved, innovation has flourished. As Roberson notes in Digital Trends, “Private, commercial spaceflight. Even lunar exploration, mining, and colonization—it’s suddenly all on the table, making the race for space today more vital than it has felt in years.”

One can see this vitality plainly in the news. On Sept. 21, Japan announced that two of its unmanned rovers, dubbed Minerva-II-1, had landed on a small, distant asteroid. For perspective, the scale of this landing is similar to hitting a 6-centimeter target from 20,000 kilometers away. And earlier this year, people around the world watched in awe as SpaceX’s Falcon Heavy rocket successfully launched and, more impressively, returned its two boosters to a landing pad in a synchronized ballet of epic proportions.

Challenges and Opportunities
Amidst the growth of capital, firms, and knowledge, both researchers and practitioners must figure out how entities should manage their daily operations, organize their supply chain, and develop sustainable operations in space. This is complicated by the hurdles space poses: distance, gravity, inhospitable environments, and information scarcity.

One of the greatest challenges involves actually getting the things people want in space, into space. Manufacturing everything on Earth and then launching it with rockets is expensive and restrictive. A company called Made In Space is taking a different approach by maintaining an additive manufacturing facility on the International Space Station and 3D printing right in space. Tools, spare parts, and medical devices for the crew can all be created on demand. The benefits include more flexibility and better inventory management on the space station. In addition, certain products can be produced better in space than on Earth, such as pure optical fiber.

How should companies determine the value of manufacturing in space? Where should capacity be built and how should it be scaled up? The figure below breaks up the origin and destination of goods between Earth and space and arranges products into quadrants. Humans have mastered the lower left quadrant, made on Earth—for use on Earth. Moving clockwise from there, each quadrant introduces new challenges, for which we have less and less expertise.

A framework of Earth-space operations. Wooten, J. and C. Tang (2018) Operations in Space, Decision Sciences, CC BY-ND
I first became interested in this particular problem as I listened to a panel of robotics experts discuss building a colony on Mars (in our third quadrant). You can’t build the structures on Earth and easily send them to Mars, so you must manufacture there. But putting human builders in that extreme environment is equally problematic. Essentially, an entirely new mode of production using robots and automation in an advance envoy may be required.

Resources in Space
You might wonder where one gets the materials for manufacturing in space, but there is actually an abundance of resources: Metals for manufacturing can be found within asteroids, water for rocket fuel is frozen as ice on planets and moons, and rare elements like helium-3 for energy are embedded in the crust of the moon. If we brought that particular isotope back to Earth, we could eliminate our dependence on fossil fuels.

As demonstrated by the recent Minerva-II-1 asteroid landing, people are acquiring the technical know-how to locate and navigate to these materials. But extraction and transport are open questions.

How do these cases change the economics in the space industry? Already, companies like Planetary Resources, Moon Express, Deep Space Industries, and Asterank are organizing to address these opportunities. And scholars are beginning to outline how to navigate questions of property rights, exploitation and partnerships.

Threats From Space Junk
A computer-generated image of objects in Earth orbit that are currently being tracked. Approximately 95 percent of the objects in this illustration are orbital debris – not functional satellites. The dots represent the current location of each item. The orbital debris dots are scaled according to the image size of the graphic to optimize their visibility and are not scaled to Earth. NASA
The movie “Gravity” opens with a Russian satellite exploding, which sets off a chain reaction of destruction thanks to debris hitting a space shuttle, the Hubble telescope, and part of the International Space Station. The sequence, while not perfectly plausible as written, is a very real phenomenon. In fact, in 2013, a Russian satellite disintegrated when it was hit with fragments from a Chinese satellite that exploded in 2007. Known as the Kessler effect, the danger from the 500,000-plus pieces of space debris has already gotten some attention in public policy circles. How should one prevent, reduce or mitigate this risk? Quantifying the environmental impact of the space industry and addressing sustainable operations is still to come.

NASA scientist Mark Matney is seen through a fist-sized hole in a 3-inch thick piece of aluminum at Johnson Space Center’s orbital debris program lab. The hole was created by a thumb-size piece of material hitting the metal at very high speed simulating possible damage from space junk. AP Photo/Pat Sullivan
What’s Next?
It’s true that space is becoming just another place to do business. There are companies that will handle the logistics of getting your destined-for-space module on board a rocket; there are companies that will fly those rockets to the International Space Station; and there are others that can make a replacement part once there.

What comes next? In one sense, it’s anybody’s guess, but all signs point to this new industry forging ahead. A new breakthrough could alter the speed, but the course seems set: exploring farther away from home, whether that’s the moon, asteroids, or Mars. It’s hard to believe that 10 years ago, SpaceX launches were yet to be successful. Today, a vibrant private sector consists of scores of companies working on everything from commercial spacecraft and rocket propulsion to space mining and food production. The next step is working to solidify the business practices and mature the industry.

Standing in a large hall at the University of Pittsburgh as part of the White House Frontiers Conference, I see the future. Wrapped around my head are state-of-the-art virtual reality goggles. I’m looking at the surface of Mars. Every detail is immediate and crisp. This is not just a video game or an aimless exercise. The scientific community has poured resources into such efforts because exploration is preceded by information. And who knows, maybe 10 years from now, someone will be standing on the actual surface of Mars.

Image Credit: SpaceX

Joel Wooten, Assistant Professor of Management Science, University of South Carolina

This article is republished from The Conversation under a Creative Commons license. Read the original article. Continue reading →

Once upon a time, a powerful Sumerian king named Gilgamesh went on a quest, as such characters often do in these stories of myth and legend. Gilgamesh had witnessed the death of his best friend, Enkidu, and, fearing a similar fate, went in search of immortality. The great king failed to find the secret of eternal life but took solace that his deeds would live well beyond his mortal years.

Fast-forward four thousand years, give or take a century, and Gilgamesh (as famous as any B-list celebrity today, despite the passage of time) would probably be heartened to learn that many others have taken up his search for longevity. Today, though, instead of battling epic monsters and the machinations of fickle gods, those seeking to enhance and extend life are cutting-edge scientists and visionary entrepreneurs who are helping unlock the secrets of human biology.

Chief among them is Aubrey de Grey, a biomedical gerontologist who founded the SENS Research Foundation, a Silicon Valley-based research organization that seeks to advance the application of regenerative medicine to age-related diseases. SENS stands for Strategies for Engineered Negligible Senescence, a term coined by de Grey to describe a broad array (seven, to be precise) of medical interventions that attempt to repair or prevent different types of molecular and cellular damage that eventually lead to age-related diseases like cancer and Alzheimer’s.

Many of the strategies focus on senescent cells, which accumulate in tissues and organs as people age. Not quite dead, senescent cells stop dividing but are still metabolically active, spewing out all sorts of proteins and other molecules that can cause inflammation and other problems. In a young body, that’s usually not a problem (and probably part of general biological maintenance), as a healthy immune system can go to work to put out most fires.

However, as we age, senescent cells continue to accumulate, and at some point the immune system retires from fire watch. Welcome to old age.

Of Mice and Men
Researchers like de Grey believe that treating the cellular underpinnings of aging could not only prevent disease but significantly extend human lifespans. How long? Well, if you’re talking to de Grey, Biblical proportions—on the order of centuries.

De Grey says that science has made great strides toward that end in the last 15 years, such as the ability to copy mitochondrial DNA to the nucleus. Mitochondria serve as the power plant of the cell but are highly susceptible to mutations that lead to cellular degeneration. Copying the mitochondrial DNA into the nucleus would help protect it from damage.

Another achievement occurred about six years ago when scientists first figured out how to kill senescent cells. That discovery led to a spate of new experiments in mice indicating that removing these ticking-time-bomb cells prevented disease and even extended their lifespans. Now the anti-aging therapy is about to be tested in humans.

“As for the next few years, I think the stream of advances is likely to become a flood—once the first steps are made, things get progressively easier and faster,” de Grey tells Singularity Hub. “I think there’s a good chance that we will achieve really dramatic rejuvenation of mice within only six to eight years: maybe taking middle-aged mice and doubling their remaining lifespan, which is an order of magnitude more than can be done today.”

Not Horsing Around
Richard G.A. Faragher, a professor of biogerontology at the University of Brighton in the United Kingdom, recently made discoveries in the lab regarding the rejuvenation of senescent cells with chemical compounds found in foods like chocolate and red wine. He hopes to apply his findings to an animal model in the future—in this case,horses.

“We have been very fortunate in receiving some funding from an animal welfare charity to look at potential treatments for older horses,” he explains to Singularity Hub in an email. “I think this is a great idea. Many aspects of the physiology we are studying are common between horses and humans.”

What Faragher and his colleagues demonstrated in a paper published in BMC Cell Biology last year was that resveralogues, chemicals based on resveratrol, were able to reactivate a protein called a splicing factor that is involved in gene regulation. Within hours, the chemicals caused the cells to rejuvenate and start dividing like younger cells.

“If treatments work in our old pony systems, then I am sure they could be translated into clinical trials in humans,” Faragher says. “How long is purely a matter of money. Given suitable funding, I would hope to see a trial within five years.”

Show Them the Money
Faragher argues that the recent breakthroughs aren’t because a result of emerging technologies like artificial intelligence or the gene-editing tool CRISPR, but a paradigm shift in how scientists understand the underpinnings of cellular aging. Solving the “aging problem” isn’t a question of technology but of money, he says.

“Frankly, when AI and CRISPR have removed cystic fibrosis, Duchenne muscular dystrophy or Gaucher syndrome, I’ll be much more willing to hear tales of amazing progress. Go fix a single, highly penetrant genetic disease in the population using this flashy stuff and then we’ll talk,” he says. “My faith resides in the most potent technological development of all: money.”

De Grey is less flippant about the role that technology will play in the quest to defeat aging. AI, CRISPR, protein engineering, advances in stem cell therapies, and immune system engineering—all will have a part.

“There is not really anything distinctive about the ways in which these technologies will contribute,” he says. “What’s distinctive is that we will need all of these technologies, because there are so many different types of damage to repair and they each require different tricks.”

It’s in the Blood
A startup in the San Francisco Bay Area believes machines can play a big role in discovering the right combination of factors that lead to longer and healthier lives—and then develop drugs that exploit those findings.

BioAge Labs raised nearly $11 million last year for its machine learning platform that crunches big data sets to find blood factors, such as proteins or metabolites, that are tied to a person’s underlying biological age. The startup claims that these factors can predict how long a person will live.

“Our interest in this comes out of research into parabiosis, where joining the circulatory systems of old and young mice—so that they share the same blood—has been demonstrated to make old mice healthier and more robust,” Dr. Eric Morgen, chief medical officer at BioAge, tells Singularity Hub.

Based on that idea, he explains, it should be possible to alter those good or bad factors to produce a rejuvenating effect.

“Our main focus at BioAge is to identify these types of factors in our human cohort data, characterize the important molecular pathways they are involved in, and then drug those pathways,” he says. “This is a really hard problem, and we use machine learning to mine these complex datasets to determine which individual factors and molecular pathways best reflect biological age.”

Saving for the Future
Of course, there’s no telling when any of these anti-aging therapies will come to market. That’s why Forever Labs, a biotechnology startup out of Ann Arbor, Michigan, wants your stem cells now. The company offers a service to cryogenically freeze stem cells taken from bone marrow.

The theory behind the procedure, according to Forever Labs CEO Steven Clausnitzer, is based on research showing that stem cells may be a key component for repairing cellular damage. That’s because stem cells can develop into many different cell types and can divide endlessly to replenish other cells. Clausnitzer notes that there are upwards of a thousand clinical studies looking at using stem cells to treat age-related conditions such as cardiovascular disease.

However, stem cells come with their own expiration date, which usually coincides with the age that most people start experiencing serious health problems. Stem cells harvested from bone marrow at a younger age can potentially provide a therapeutic resource in the future.

“We believe strongly that by having access to your own best possible selves, you’re going to be well positioned to lead healthier, longer lives,” he tells Singularity Hub.

“There’s a compelling argument to be made that if you started to maintain the bone marrow population, the amount of nuclear cells in your bone marrow, and to re-up them so that they aren’t declining with age, it stands to reason that you could absolutely mitigate things like cardiovascular disease and stroke and Alzheimer’s,” he adds.

Clausnitzer notes that the stored stem cells can be used today in developing therapies to treat chronic conditions such as osteoarthritis. However, the more exciting prospect—and the reason he put his own 38-year-old stem cells on ice—is that he believes future stem cell therapies can help stave off the ravages of age-related disease.

“I can start reintroducing them not to treat age-related disease but to treat the decline in the stem-cell niche itself, so that I don’t ever get an age-related disease,” he says. “I don’t think that it equates to immortality, but it certainly is a step in that direction.”

Indecisive on Immortality
The societal implications of a longer-living human species are a guessing game at this point. We do know that by mid-century, the global population of those aged 65 and older will reach 1.6 billion, while those older than 80 will hit nearly 450 million, according to the National Academies of Science. If many of those people could enjoy healthy lives in their twilight years, an enormous medical cost could be avoided.

Faragher is certainly working toward a future where human health is ubiquitous. Human immortality is another question entirely.

“The longer lifespans become, the more heavily we may need to control birth rates and thus we may have fewer new minds. This could have a heavy ‘opportunity cost’ in terms of progress,” he says.

And does anyone truly want to live forever?

“There have been happy moments in my life but I have also suffered some traumatic disappointments. No [drug] will wash those experiences out of me,” Faragher says. “I no longer view my future with unqualified enthusiasm, and I do not think I am the only middle-aged man to feel that way. I don’t think it is an accident that so many ‘immortalists’ are young.