Effect of High Local Concentrations of Antibiotics on Early Bone Formation with Tooth Ash and Plaster of Paris in the Ovariectomized Rat

Abstract:

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This studied determined the clinical effect of antibiotic use at the site of bone
defect restoration in patients with osteoporosis, using tooth ash and plaster of Paris in
ovariectomized rats. Forty-eight rats were assigned to four groups randomly and each
group was further divided into 4 and 8 weeks after implantation. Histologic sections of
the defects were obtained after surgery for histomorphometric analysis. Comparing each
week, a significant difference was seen in bone formation by 4 weeks. Compared to
controls, new bone formation increased significantly with tooth ash and saline, tooth ash
and gentamicin, and tooth ash and gentamicin after ovariectomy. Tooth ash and saline
resulted in the best bone formation. The degree of new bone formation was slightly
lower when tooth ash and gentamicin were used compared to when tooth ash and saline
were used. When tooth ash and gentamicin were compared according to ovariectomy,
bone formation was significantly inhibited by ovariectomy at 4 weeks, while no
significant difference was seen at 8 weeks.

S.G. Kim et al., "Effect of High Local Concentrations of Antibiotics on Early Bone Formation with Tooth Ash and Plaster of Paris in the Ovariectomized Rat", Key Engineering Materials, Vols. 330-332, pp. 1311-1314, 2007