ACQUITY UPLC System

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Waters ACQUITY UPLC - Dramatic Improvements in Speed, Sensitivity and Resolution Whether you work in methods development or quality assurance, in drug discovery and development or testing for safety in food supplies, you seek a productivity edge. With the ACQUITY UPLC® System, now you can get more information in a single, short run than you've ever seen with HPLC. Waters ACQUITY UPLC System UltraPerformance LC® (UPLC®) technology starts with unique 1.7 μm small-particle chemistries. Chromatographers no longer need to choose between speed and resolution–with UPLC you get both. Instrument Designed for Chemistry; Chemistry Designed for the Instrument The ACQUITY UPLC System has been holistically designed to match the performance needs of our innovative column chemistries with robust hardwa...Read more

"This ACQUITY UPLC System supports us for drug discovery including small molecules and also testing for safety in food materials. Now we can get more information in a single, short run than usual HPLC. So it saved money, labor and supports a lots for our research. "

"This high-end sophisticated product is best suited for existing HPLC methods and also for new methods in terms of speed without compromising resolution and sensitivity. A very good tool for impurity profiling and method development.
In today's fast world, where high productivity in terms of sample analysis is expected in less time this product is an apt answer. Not only it is faster but you can combine it with any detector either of Waters makes or of a different manufacturer which makes its applications even more wider which is a good value for money.
And with Waters own "Empower" software it becomes easier to operate even for a novice person.
A must have for each Analytical laboratory.
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"The instrument works fine. However its Empower software is difficult to use unless you are very familiar with it and use it every day. For molecular weight measurement, the software cannot give numbers based on individual peaks and whole chromatograph at the same time. But the after sales service is excellent. "

"We use the UPLC system in our company and we have been able to analyze our samples in a more rapid and reproducible manner. I think it is a technique that helps pharmaceutical laboratories to quickly bring to market their products. "

"Excellent system, Waters was the 1st on the market of UPLC so their systems are easy to use, very robust and have extremely less carry over issues with their needle in peek. The dead volume is extremely small."

"The system is functional and it meets its needs for large molecule analysis, but for residue studies it has its problems with carry over. Also when control by other software besides waters there are many communication issues. It is a useful tool and it is easy to work with, but I would recommend not using it for residue chemistry, unless someone has validated the method and you know the problems from the beginning.
However it is very useful connected to a ToF Mass Spec for Proteomics I have seen great results for peptide ID it tends to handle buffers better than other systems.
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"The sample derivatization method is easy to implement. The separation of amino acids with UPLC worked immediately without any method tuning or problems. The cleaning procedure of the UPLC after other analyses is quite demanding (takes one day), so maybe not be very applicable if the instrument is used also for other analyses or at least demands good planning of the instrument use. The eluents are quite expensive and according to label suitable for use for one month after opening. Thus method is quite expensive if analyses are done rarely."

"The Waters Acquity UPLC system has been in our lab now for about 4 years and we are very satisfied with it. It is nice with very few problems. Firstly we coupled it to a Quattro Premier Mass spec, but as soon as we bought a Xevo TQS we coupled it to that one."

"It is a good technique, easy and friendly to use. The software is intuitive in MS and UV and gives a high performance of resolution and a good speed. The instrument tolerates high pressure and high flow rate. I really recommend this apparatus."

"I would recommend this product as it is easy to setup and use. However, there are communication issues when you control it through non-Waters software. Waters is also very helpful for questions and additional training."

"Allows for fast analysis of samples, however we are currently having repeatability issues. Installation is quick and easy. When working properly it will allow for quick method development and quicker sample turnaround times with little eluent use."

"The instrument is useful because it shortens analysis time leading to higher productivity. It also uses smaller sample sizes and uses less solvent so it is more economical and environmentally friendly as well."

"The Waters Acquity UPLC system is the best UHPLC on the market. Their pump technology is unrivalled in the industry. Our LC run times have gone down to 1/4 of original and we save money on solvents and consumables."

"The Waters Acquity UPLC system is great because it offers excellent sensitivity and resolution. It is a very reliable instrument. It is my UPLC of choice and I would absolutely recommend it to a colleague."

"The waters Acquity UPLC is heavily utilized daily in my laboratory for bioanalytical assays of proteins and small molecule residuals. The resolution and sensitivity that can be achieved is worth the cost. The Empower software is easy to use after a slightly difficult learning period. At first the software seemed difficult (relative to Chemstation) but now that I am using it often I prefer Empower. One great benefit is the Acquity console that controls instrument and column and has easy access to column information and literature. This instrument is critical for our success."

"The UPLC has been a great addition to the lab, however, it does require a lot of service. We have had to call in the vendor on several occasions to fix the check valve. When it is working properly, the instrument has been beneficial to the lab."

"This system has been robust in our walk-up LC/MS environment. The unit sees heavy use with little downtime. I would definitely recommend the Acquity Classic for anyone considering walk-up LC/MS applications."

"In my lab, we use the Acquity UPLC H -Class as its use in the biopharmaceutics makes it easy to run in high salt conditions. The flow path is completely steel free making it more robust against salt build up. To quantitate data, Empower makes it very easy to run many samples and process data."

"UPLC saves time by reducing the run time. It’s very efficient and uses less solvent with a faster run time. UPLC is able to produce better chromatography by providing sharp peaks and a complete resolution between many analytes that are being separated from the sample substance in question."

"The instrument is easy to use, and easy to track column history with the chip. However, the system column installation is not quite user friendly. I like the fusion system that has been developed to support method development using UPLC. However, the software seems only include statistic function, but not the chromatographic basic theory. In general, I like the system. "

"Waters' UPLC and LCMS systems with the Masslynx platform offer the most reliable and versatile systems in the world. In addition to their ruggedness, Waters as a company offers outstanding after the sale service. Engineers are well trained in all aspects of their instruments and are readily available to help. In my experience, first response takes no longer than 24 hrs and a solution is reached between 24 to 72 hrs. Their telephone support is remarkable, you no longer have to leave a message and someone has to get back to you to solve your issue. The person answering the call is the person who will help and solve your issue. They also have the capability to log into your computer system to fix any problems directly from Milford. I have experience with other vendors in the same area as we also have competitors LC/MS systems and compared side to side, Waters by far tops them all."

"A robust instrument, however there are no leak detectors which can be problematic in the column department. Using the Empower software for the instrument can be challenging. Technical support for the instrument has been great. Service engineers respond within 12-24 hours."

"Operates at high pressures, up to 15,000 psi. Good resolution with a wide range of linear velocities. It has a rapid analysis time and the high resolution results in narrow peak widths and an increased signal/noise ratio."

"Equipment is great for taking existing HPLC methods and converting them to faster more resolved UPLC methods. The system compliments nicely to UPLC H-Class in ease of use and affordability. Customer service is always willing to help when a problem arises. Service is prompt and excellent."

"Using the Acquity we are able to reduce analysis time and solvent usage/waste (and preparing less mobile phase takes less labtime as well). The Waters support is fantastic; their engineers 'know their stuff' and work to constantly improve the product. The resolution tends to be better with the UPLC (vs. HPLC), and I've found the instruments to be as robust as typical HPLCs. The columns will clog more easily, however I've found that a pre-column filter saves the column if there are large particulates in the sample."

Description

Whether you work in methods development or quality assurance, in drug discovery and development or testing for safety in food supplies, you seek a productivity edge. With the ACQUITY UPLC® System, now you can get more information in a single, short run than you've ever seen with HPLC.

Instrument Designed for Chemistry; Chemistry Designed for the Instrument The ACQUITY UPLC System has been holistically designed to match the performance needs of our innovative column chemistries with robust hardware, easy-to-use software and specialized support services.

Small, pressure-tolerant particles

High-pressure fluidic modules

Minimized system volume

Negligible carryover

Reduced cycle times

Fast response detectors

Integrated system software and diagnostics

With UPLC you have the ability to work more efficiently with higher speed, sensitivity and resolution at a much wider range of linear velocities, flow rates and backpressures to obtain superior results.

The Waters ACQUITY UPLC System's high-pressure fluidics optimizes flow rates to make the most of small particle technology. The ACQUITY UPLC System's sample-handling design is designed to ensure exceptionally low carryover and reduced cycle time. And when interfaced with the Sample Organizer, it increases unattended sample capacity by ten times.

High-speed detectors, both optical and mass, contribute to increased sensitivity and help manage the heightened speed and resolution requirements of UPLC.