Description of the project This project is focused on the application of a new technology (Speck technology) for the design of safe anti-breast cancer chemicals. In order to accomplish this purpose, all the chemical and biological data will be extracted from the free online source known as CHEMBL database. After,. . . . .

Description of the project

This project is focused on the application of a new technology (Speck technology) for the design of safe anti-breast cancer chemicals. In order to accomplish this purpose, all the chemical and biological data will be extracted from the free online source known as CHEMBL database. After, a series of computer simulations will be performed, and from them, computational models will be obtained. Such models will be able to predict anti-breast cancer activity, toxicity, and other properties of the chemicals. Subsequently, a series of fragments (pieces of chemicals) will be extracted and ranked according to their intrinsic (physicochemical) properties. Then, the “puzzle approach” will be applied; the best fragments will be assembled as pieces of a puzzle in order to create new chemicals with improved anti-breast cancer activity, low toxicity, etc. These chemicals designed by using the Speck technology will undergo experimental validation. In that way, pharmaceutical companies will be able to benefit from the result of the Speck technology, and the discovery of more effective and safer anti-breast cancer drugs will be accelerated. Thus more lives will be saved.

Risks and Challenges

There are two main risks that come with completing this project:

The first risk is the time associated with the experimental validation. This task will be performed by specialized companies, and it constitutes the prime reason for the fundraising in this project. Depending on the number of tests, the experimental validation can take 3-5 months, but it can be delayed by other factors that escape my control such as the volume of experiments that the specialized companies need to perform for other clients.

The results of the Speck technology will be published in a prestigious international journal, and they will be made available free of charge to the public. Therefore, the second risk is the time associated with the review process that each scientific article must undergo. In this context, the article will be sent to a very prestigious international journal, and it will be revised by the journal editor for a first assessment. After that, the journal editor will send the article for further revision to external reviewers (experts whose fields of research are similar or related to the content of the article). These reviewers will suggest a series of modifications that should be made in order to improve the quality of the article. After, I will make the appropriate corrections, and I will send the reviewed version of the article to the journal editor, who will decide based on my corrections whether to accept or reject the article for publication in the journal. With the acceptance of the article, the article proof will be created by the journal editorial team, and I will have the chance to correct any error that could occur during the process of editing the article. After that, the journal will schedule a data when my article will be published. The whole process may take 4 months. However, delays can occur due to the change in the internal rules of the journal for publication of the articles or the breach of deadlines for delivery of review reports made by reviewers.

I have 9 years of experience in science, and I am confident that taking into consideration the deadline to deliver the results of the project (December 2018), the best way to prevent the effect of the aforementioned risks is to expedite the first stage of the project, which is the part focused on extracting chemical and biological data and performing computational simulations. I am already working on the extraction of all data, which are being curated (corrected in order to avoid potential errors). By the time the funding will be received, all the data will be ready to perform computational simulations which may take around 4 months.

Most of the money in this project is for experimental validation, and there is a percentage that includes fees. I would like to say that if I receive more funding than expected, the extra funding will be employed to buy equipment and accelerate the computational simulations. As you can see, I am not asking for any money for my work, which is a very important part of the project. I decided to volunteer to do this work in order to accelerate the drug discovery process and save more lives.

Description of the project

This project is focused on the application of a new technology (Speck technology) for the design of safe anti-breast cancer chemicals. In order to accomplish this purpose, all the chemical and biological data will be extracted from the free online source known as CHEMBL database. After, a series of computer simulations will be performed, and from them, computational models will be obtained. Such models will be able to predict anti-breast cancer activity, toxicity, and other properties of the chemicals. Subsequently, a series of fragments (pieces of chemicals) will be extracted and ranked according to their intrinsic (physicochemical) properties. Then, the “puzzle approach” will be applied; the best fragments will be assembled as pieces of a puzzle in order to create new chemicals with improved anti-breast cancer activity, low toxicity, etc. These chemicals designed by using the Speck technology will undergo experimental validation. In that way, pharmaceutical companies will be able to benefit from the result of the Speck technology, and the discovery of more effective and safer anti-breast cancer drugs will be accelerated. Thus more lives will be saved.

Risks and Challenges

There are two main risks that come with completing this project:

The first risk is the time associated with the experimental validation. This task will be performed by specialized companies, and it constitutes the prime reason for the fundraising in this project. Depending on the number of tests, the experimental validation can take 3-5 months, but it can be delayed by other factors that escape my control such as the volume of experiments that the specialized companies need to perform for other clients.

The results of the Speck technology will be published in a prestigious international journal, and they will be made available free of charge to the public. Therefore, the second risk is the time associated with the review process that each scientific article must undergo. In this context, the article will be sent to a very prestigious international journal, and it will be revised by the journal editor for a first assessment. After that, the journal editor will send the article for further revision to external reviewers (experts whose fields of research are similar or related to the content of the article). These reviewers will suggest a series of modifications that should be made in order to improve the quality of the article. After, I will make the appropriate corrections, and I will send the reviewed version of the article to the journal editor, who will decide based on my corrections whether to accept or reject the article for publication in the journal. With the acceptance of the article, the article proof will be created by the journal editorial team, and I will have the chance to correct any error that could occur during the process of editing the article. After that, the journal will schedule a data when my article will be published. The whole process may take 4 months. However, delays can occur due to the change in the internal rules of the journal for publication of the articles or the breach of deadlines for delivery of review reports made by reviewers.

I have 9 years of experience in science, and I am confident that taking into consideration the deadline to deliver the results of the project (December 2018), the best way to prevent the effect of the aforementioned risks is to expedite the first stage of the project, which is the part focused on extracting chemical and biological data and performing computational simulations. I am already working on the extraction of all data, which are being curated (corrected in order to avoid potential errors). By the time the funding will be received, all the data will be ready to perform computational simulations which may take around 4 months.

Most of the money in this project is for experimental validation, and there is a percentage that includes fees. I would like to say that if I receive more funding than expected, the extra funding will be employed to buy equipment and accelerate the computational simulations. As you can see, I am not asking for any money for my work, which is a very important part of the project. I decided to volunteer to do this work in order to accelerate the drug discovery process and save more lives.

I obtained my Degree in Chemistry in 2005, at the University of Oriente, Santiago de Cuba, Cuba. During five years, I studied this wonderful career with the aim of making a difference. However, unlike USA or European Union countries, and due to economic problems, the Cuban government does not provide funding to undertake high-level degrees such as masters and doctorates. This, together with the hidden racism (which I suffered during a part of my university career) made me explore the option of abandoning my country to pursue a scientific career to help people and have a better life. Thus, in 2009, I decided to travel to Spain in order to obtain my PhD. in Chemistry or related science.

I also realized that even in the 21st century and with the great development achieved by capitalist countries in the European Union, there were (and still there are) strong tendencies to xenophobia and racism in the society. Check the following links, and you will be able to see the cruel reality:

I learned that as a Latin American (Cuban) black person I would have to be two or three times better than any European Union citizen to be noticed in its professional career.

The period 2010-2015 was crucial for me. It was not an easy path but I obtained a Master Degree in Science and Technology of Colloids and Interfaces (University of Santiago de Compostela, Spain, 2015) and a PhD Degree in Chemistry (University of Porto, Portugal). During this time, I published 54 scientific articles in different international journals (in more than 70% I was the principal author).

I thought that with my CV (which was above the standards even for USA and European Union countries) everything would be easier, and I would be able to get a scientific position. I was wrong! And I learned two important things. First, obtaining a scientific position is not related to how good your CV is.

Second, the European Union countries have achieved such an economic and social development that for many people, despite the prevalence of certain groups of dangerous diseases such as cancer, science is just a job. Therefore, with this way of thinking, many scientists are devoted to similar things, applying similar methodologies and approaches. Genuinely new ideas are not encouraged, and in the scientific groups, the ego and the ambition to achieve things for the benefit of a few individuals prevail over the passion of making a difference. That contradicts the sacred purpose of science: to help people and make the world a better place to live.

During my 9 years of scientific career, I have always been focused on creating publishing interesting and innovative ideas. But for many scientists, logic is the sole way of thinking and getting results, while the creative way of generating ideas is a heresy. For this reason, I was (and still I am) heavily criticized for looking for different approaches instead of applying the conventional ones. And of course, all this has negative repercussions even at the highest levels of professionalism. For example in my area of research (drug discovery), and due to the ideas commented above, one of the largest pharmaceutical companies has decided to stop many important preclinical and clinical studies focused on treating different diseases (https://european-biotechnology.com/up-to-date/latest-news/news/gsk-cancels-30-preclinical-and-clinical-programmes.html). What causes this failure? It’s the use and abuse of conventional ideas.

Being tired of all this misuse of science, and by using powerful alternative technologies, I have decided to take a step forward and make a real difference, a real positive impact in the lives of those millions of people suffering from cancer. I cannot wait any longer for the scientific community to wake up and do something about it (to be ready for new approaches) while people suffer and die. So, I hope we can make a difference together, bringing to light alternative technologies to cure cancer, and hopefully, we will be able to save lives.

I will share a link with you, where you will have free access to the article containing the results of the application of the Speck technology. In addition, I will answer 3 questions (via e-mail) that you will ask me regarding the project.

I will share a link with you, where you will have free access to the article containing the results of the application of the Speck technology. In addition, you will be able to assist a webinar, where I will talk about all updates of the project, as well as future perspective, potential for application to other types of cancer, etc. I will answer one question per member in the webinar.

I will share a link with you, where you will have free access to the article containing the results of the application of the Speck technology. In addition, you will be able to assist a webinar, where I will talk about all updates of the project, as well as future perspective, potential for application to other types of cancer, etc. I will answer one question per member in the webinar. You will also have the right to a 30 minutes personal interview via Skype, where I will answer as many questions as you want.

I will share a link with you, where you will have free access to the article containing the results of the application of the Speck technology. In addition, I will answer 3 questions (via e-mail) that you will ask me regarding the project.

I will share a link with you, where you will have free access to the article containing the results of the application of the Speck technology. In addition, you will be able to assist a webinar, where I will talk about all updates of the project, as well as future perspective, potential for application to other types of cancer, etc. I will answer one question per member in the webinar.

I will share a link with you, where you will have free access to the article containing the results of the application of the Speck technology. In addition, you will be able to assist a webinar, where I will talk about all updates of the project, as well as future perspective, potential for application to other types of cancer, etc. I will answer one question per member in the webinar. You will also have the right to a 30 minutes personal interview via Skype, where I will answer as many questions as you want.

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I would like to share with you a little bit of my story:I obtained my Degree in Chemistry in 2005, at the University of Oriente, Santiago de Cuba, Cuba. During five years, I studied this wonderful career with the aim of making a difference. However, …

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