Bredesen Protocol

Contents

Introduction

Dr. Dale Bredesen has created the ReCODE protocol that involves multiple strategies to address specific health issues that contribute to Alzheimer's Disease (AD). The results of each strategy are measured by using blood tests, cognitive evaluations, and other markers of overall health improvements. Actions are tweaked over time to aim for optimal lab and evaluation results. His analogy is to think of AD as a leaky roof - there are as many as 36 leaks in the AD roof that need to be addressed to stop the problem. Not every patient will have the same leaks, and the protocol is customized based on the patient’s genetics, current health, and lifestyle.

His first published paper on the protocol, Reversal of Cognitive Decline, highlighted 10 case studies. Of those 10 people, nine showed enough improvement to return to normal life activities. Since then, several hundred people with cognitive impairment have followed the protocol, and most have seen a reversal of cognitive impairment. Dr. Bredesen is currently partnering with the Cleveland Clinic to test the protocol in a larger trial.

Although Bredesen does not see private patients, he is in the process of making the protocol available to the wider public with the help of doctors certified in the protocol through MPI Cognition. His previous affiliation with Muses Labs has ended.

Bredesen’s protocol has not been tested as a preventative. That said, research has shown that amyloid-β is deposited in E4 carriers as early as their thirties, so addressing components early will likely lead to better health in aging. Members on the APOE4.Info forum who follow the protocol report improvements not only in health but also in cognition, even if they do not have an SCI or MCI diagnosis.

The following list links to summaries of why each strategy is important, what you can do, and a selection of research references.

Resources

Tracking results:
Our member "optimize" made a Google spreadsheet using the recommended Cognoscopy test values in The End of Alzheimer's. This spreadsheet is a simple table to help you track your latest test results, with values flagged as "high", "low", or "in range". It's intended as a quick way to organize test results, and see at a glance where to make improvements.

Please note! The copied spreadsheet will let you type in the white areas, but this may cause errors in the formulas. If you accidentally type in a white area, hit "ctrl-Z" a few times to remove the typing, or download a fresh copy of the spreadsheet.

Summary of key tests for ReCode Protocol
Taken from Dr Bredesen's book The End of Alzheimer's provided for quick reference, refer to the book for specific information

The first version of Dr Bredesen’s protocol (which is similar to the above) can be found in his paper: Reversal of cognitive decline: A novel therapeutic program, published September 2014, https://www.ncbi.nlm.nih.gov/pubmed/25324467

Subsequent papers of Dr Bredesen do not address his protocol, but further examine his findings. They include:

This paper addresses the common criticism that the original paper only covered a small number of patients. This paper documents improvement in cognition of 100 patients treated by several different physicians thus providing further support for a randomized, controlled clinical trial of the protocol and overall approach: