This forum is for questions about medical issues and research aspects of Hepatitis C such as, questions about being newly diagnosed, questions about current treatments, information and participation in discussions about research studies and clinical trials related to Hepatitis. If you would like to communicate with other people who have been touched by Hepatitis, please visit our new Hepatitis Social/Living with Hepatitis forum

new treatments coming along question

I am confused about the new treatments. Can anyone tell me more about the Sofosbuvir, Ledipasvir Combo Therapy? The alternate and off label names are hard to keep straight. Is there a trial anywhere without the riba and interferon? Trying to find out for a friend that is a 1a. I almost have convinced him it is time to treat! Any help would be appreciated. Unfortunately my friend has no insurance and poor as a church mouse. He will not treat with interferon. Im trying to make him understand he needs to find out his liver status. last biopsy was in 04 and he had some scaring but he couldnt tell me what stage he was. He also had a bad experience with the biopsy. Just a bunch of bad luck for him. He also has horrible guilt because he use to donate blood a lot not knowing he had it. When one day they sent him a letter that he tested positive when the test first was used to test the blood supply.

BMS triple non interferon trial started in January and Gilead 's for Cirrhotic was also January and all if filled at my local labs. I know of no others at the moment. The BMS that Hrsepwrguy mentions above in Texas is all filled in Calif. where I am. I have a friend in the trial and on 4th week. Has been UND since week 2. Doing really well !

Gilead filed for approval for combo of SOF/LDV recently
http://www.gilead.com/news/press-releases/2014/2/gilead-files-for-us-approval-of-ledipasvirsofosbuvir-fixeddose-combination-tablet-for-genotype-1-hepatitis-c

They filed April 2013 for Sofosbuvir alone and it was approved in December, so this combo pill should be approved by late fall?

Thanks for your replies! My friend lives in VA and I have sent him all I could find on research centers there. Will this combo pill be for 1a's. with no interferon or riba? How will people pay for it with no insurance?? I was hoping to help him find a phase 3 trial. Oh I see the link purplecat. I will go look at it. Thanks!!

The NCT01979939 , I did look into this trial and it looks very promising for my friend. He needs to get into a trial due to finances. They are not yet recruiting where he lives in VA near newport news, but they are in mt. vernon Va which is drivable. It is also great that the bristol myer drug daclatsvir is the one which was paired up with Gileads Sofosbuvir where all the stink was raised about them not working together. So thank you also for that info!

AbbVie’s trial for an unnamed multidrug therapy is in the last of three stages typically required for U.S. approval and is moving quickly, Scott Brun, the company’s head of drug development, told investors today at a conference in New York. Gilead is seeking to bring its own multidrug regimen with its therapies sofosbuvir and ledipasvir to market next year.

“We’ve got a very good shot at being first,” Brun said at the conference hosted by Goldman Sachs Group Inc. “It is a very tight race.”

Glad you brought up the question about Ledipasvir/Sofosbuvir Combo. My doctor wants me to tx with this combination at the end of 2015 as he expects it to be approved by then. According to his numbers the percentage cured or SVR were 95% for genotype 1's, that's dang good. I haven't been on this forum for quite awhile but I had to say something when I read your post. If you can get your friend hooked up with a clinical trial site then they'll do the rest. Good luck to you and a big shout out to all my friends here on this forum. More info at the below link.

medhelp sent me a note to pick out a best answer. I did for the one hrspower sent me about the NCT01979939 trial info. but all of these answers I needed and are the best. Thank you all for your awesome time that you would take to get me the info I am looking for. and your thoughts my friends!

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