Medical Xpress news tagged with:therapeutic strategyhttp://medicalxpress.com/
en-usMedical Xpress internet news portal provides the latest news on science including: Physics, Nanotechnology, Life Sciences, Space Science, Earth Science, Environment, Health and Medicine.Novel therapeutic strategy for single gene disorders delivers RNA that encodes the missing proteinResearchers have demonstrated the feasibility of delivering an RNA that encodes for the protein alpha-1-antitrypsin (AAT)—which is missing or nonfunctional in the genetic disorder AAT deficiency—into cells in the laboratory, enabling the cells to produce highly functional AAT. This innovative approach to treating single gene disorders such as AAT deficiency offers and safe, simpler, and more cost-effective alternative to gene therapy or protein replacement, according to the authors of the study published in Nucleic Acid Therapeutics.http://medicalxpress.com/news/2015-07-therapeutic-strategy-gene-disorders-rna.html
Medical researchMon, 27 Jul 2015 11:43:32 EDTnews357216205In blinding eye disease, trash-collecting cells go awry, accelerate damageSpider-like cells inside the brain, spinal cord and eye hunt for invaders, capturing and then devouring them. These cells, called microglia, often play a beneficial role by helping to clear trash and protect the central nervous system against infection. But a new study by researchers at the National Eye Institute (NEI) shows that they also accelerate damage wrought by blinding eye disorders, such as retinitis pigmentosa. NEI is part of the National Institutes of Health.http://medicalxpress.com/news/2015-07-eye-disease-trash-collecting-cells-awry.html
OphthalmologyThu, 02 Jul 2015 08:42:17 EDTnews355045327Researchers home in on what's wearing out T cellsSometimes even cells get tired. When the T cells of your immune system are forced to deal over time with cancer or a chronic infection such as HIV or hepatitis C, they can develop 'T cell exhaustion,' becoming less effective and losing their ability to attack and destroy the invaders of the body. While the PD-1 protein pathway has long been implicated as a primary player in T cell exhaustion, a major question has been whether PD-1 actually directly causes exhaustion. A new paper from the lab of E. John Wherry, Ph.D., a professor of microbiology and director of the Institute for Immunology, in the Perelman School of Medicine at the University of Pennsylvania, seems to—at least partially—let PD-1 off the hook. The paper was published this week in the Journal of Experimental Medicine.http://medicalxpress.com/news/2015-06-home-cells.html
Medical researchWed, 03 Jun 2015 18:38:53 EDTnews352575525Case series addresses spine tumors in pregnancy(HealthDay)—For most pregnant patients with benign spine tumors, surgery can be postponed until after delivery, according to a study published in the Feb. 1 issue of Spine.http://medicalxpress.com/news/2015-02-case-series-spine-tumors-pregnancy.html
CancerMon, 09 Feb 2015 18:20:01 EDTnews342727225Type 2 diabetes: Added benefit of canagliflozin plus metformin is not provenThe fixed combination of canagliflozin with metformin (trade name: Vokanamet) has been approved since April 2014 for adults with type 2 diabetes mellitus in whom diet and exercise do not provide adequate glycaemic control. The German Institute for Quality and Efficiency in Health Care (IQWiG) now examined in a dossier assessment whether the new drug combination offers an added benefit over the appropriate comparator therapy. No such added benefit can be derived from the dossier, however, because the manufacturer did not present any suitable data for any of the possible subindications.http://medicalxpress.com/news/2014-11-diabetes-added-benefit-canagliflozin-metformin.html
MedicationsFri, 21 Nov 2014 09:53:20 EDTnews335785994New, faster therapeutic hypothermia techniquesRapid lowering of body temperature following an acute myocardial infarction (MI) can be an effective therapeutic strategy to minimize damage to the heart muscle caused by the loss and restoration of blood flow to the heart. While hypothermia shows clinical promise, current methods to cool the heart are insufficient. Faster, more effective techniques are needed to realize the full cardioprotective potential of this emerging intervention, as described in an article in Therapeutic Hypothermia and Temperature Management.http://medicalxpress.com/news/2014-10-faster-therapeutic-hypothermia-techniques.html
Diseases, Conditions, SyndromesThu, 23 Oct 2014 11:45:51 EDTnews333283545Myc inhibition is an effective therapeutic strategy against most aggressive brain tumorsResearch led by the Vall d'Hebron Institute of Oncology (VHIO) evidence the most conclusive preclinical results to-date validating Myc inhibition as a therapeutic strategy in glioma – a highly agressive tumor type that notoriously outsmarts current anti-cancer therapies. The study led by Laura Soucek, Principal Investigator of VHIO´s Mouse Models of Cancer Therapies Group, published today in Nature Communications, not only represents an important step forward in ultimately providing brain glioma patients with new therapeutic avenues, but also reveals new insights into the biology of Myc that could further impact on its therapeutic potential.http://medicalxpress.com/news/2014-08-myc-inhibition-effective-therapeutic-strategy.html
CancerMon, 18 Aug 2014 09:35:13 EDTnews327573298New method for reducing tumorigenicity in induced pluripotent stem-cell based therapiesThe potential for clinical use of induced pluripotent stem cell (iPSC) technology for transplant-based therapeutic strategies has previously been hindered by the risk of dysregulated cell growth, specifically the development of tumors. The ability to use etoposide treatment to halt teratoma formation in iPSCs for the treatment of heart disease, specifically acute myocardial infarction, is demonstrated in an article in Stem Cells and Development.http://medicalxpress.com/news/2014-07-method-tumorigenicity-pluripotent-stem-cell-based.html
Medical researchWed, 23 Jul 2014 11:10:03 EDTnews325331470Study finds cause of eosinophilic esophagitis—mysterious food allergy, suggests new treatment strategyNew research in Nature Genetics identifies a novel genetic and molecular pathway in the esophagus that causes eosinophilic esophagitis (EoE), opening up potential new therapeutic strategies for an enigmatic and hard-to-treat food allergy.http://medicalxpress.com/news/2014-07-eosinophilic-esophagitismysterious-food-allergy-treatment.html
GeneticsSun, 13 Jul 2014 13:00:05 EDTnews324405524Type 2 diabetes mellitus: Added benefit of canagliflozin is not provenCanagliflozin (trade name: Invokana) has been approved since November 2013 as monotherapy and in various combination therapies for adults with type 2 diabetes mellitus when diet and exercise alone do not provide adequate glycaemic control. In an early benefit assessment pursuant to the Act on the Reform of the Market for Medicinal Products (AMNOG), the German Institute for Quality and Efficiency in Health Care (IQWiG) now examined whether this new drug alone (monotherapy) or in combination with other blood-glucose lowering drugs offers an added benefit over the appropriate comparator therapy. No added benefit can be derived from the dossier, however, because the manufacturer did not present any suitable data for any of the possible therapeutic indications.http://medicalxpress.com/news/2014-06-diabetes-mellitus-added-benefit-canagliflozin.html
MedicationsTue, 17 Jun 2014 12:55:10 EDTnews322228500Ovarian cancer discovery deepens knowledge of survival outcomesResearchers in the Women's Cancer Program at Cedars-Sinai's Samuel Oschin Comprehensive Cancer Institute have identified a series of 10 genes that may signify a trifecta of benefits for women diagnosed with ovarian cancer and ultimately reflect improved survival outcomes.http://medicalxpress.com/news/2013-12-ovarian-cancer-discovery-deepens-knowledge.html
CancerMon, 09 Dec 2013 10:08:18 EDTnews305806087Malaria, toxoplasmosis: Toward new lines of research?A study realized by teams from the Institut Pasteur, the Institut Cochin and the Wellcome Trust Centre for Molecular Parasitology of the University of Glasgow, could redefine part of the present lines of research toward a treatment against the parasites responsible for malaria and toxoplasmosis.http://medicalxpress.com/news/2013-10-malaria-toxoplasmosis-lines.html
Medical researchThu, 10 Oct 2013 10:03:23 EDTnews300618193Protein explains increased asthma severity in children exposed to diesel exhaust from trafficA new study shows that exposure to diesel exhaust particles from traffic pollution leads to increased asthma severity in children. Moreover, the study finds that this is due to increased blood levels of IL-17A, a protein associated with several chronic inflammatory diseases, in children with high diesel exposure.http://medicalxpress.com/news/2013-09-protein-asthma-severity-children-exposed.html
ImmunologyMon, 23 Sep 2013 11:23:58 EDTnews299154229Researchers identify proteins that may help brain tumors spreadScientists at the University of Alabama at Birmingham have identified a molecular pathway that seems to contribute to the ability of malignant glioma cells in a brain tumor to spread and invade previously healthy brain tissue. Researchers said the findings, published Sept. 19, 2013, in the journal PLOS ONE, provide new drug-discovery targets to rein in the ability of these cells to move.http://medicalxpress.com/news/2013-09-proteins-brain-tumors.html
CancerMon, 23 Sep 2013 09:00:02 EDTnews299143398Research yields first detailed view of morphing Parkinson's protein(Medical Xpress)—Researchers have taken detailed images and measurements of the morphing structure of a brain protein thought to play a role in Parkinson's disease, information that could aid the development of medications to treat the condition.http://medicalxpress.com/news/2013-09-yields-view-morphing-parkinson-protein.html
Parkinson's & Movement disordersFri, 06 Sep 2013 09:30:01 EDTnews297677903Prion-like proteins drive several diseases of agingTwo leading neurology researchers have proposed a theory that could unify scientists' thinking about several neurodegenerative diseases and suggest therapeutic strategies to combat them.http://medicalxpress.com/news/2013-09-prion-like-proteins-diseases-aging.html
Medical researchThu, 05 Sep 2013 11:40:17 EDTnews297600007New recommendations for standardizing studies of thyroid hormone and disease from ATA taskforceDespite tens of thousands of studies in the literature on the thyroid gland, thyroid hormone, and thyroid disease, lack of standardization in study design makes it difficult to compare the results and apply them to the development of improved diagnostic and treatment approaches. A new report from the American Thyroid Association's Taskforce on Approaches and Strategies to Investigate Thyroid Hormone Economy includes 70 specific recommendations and accompanying commentaries on a range of topics. The report is available free online on the Thyroid website.http://medicalxpress.com/news/2013-09-standardizing-thyroid-hormone-disease-ata.html
OtherThu, 05 Sep 2013 11:27:10 EDTnews297599219Study finds tumor suppressor may actually fuel aggressive leukemiaNew research in the Journal of Clinical Investigation suggests that blocking a protein normally credited with suppressing leukemia may be a promising therapeutic strategy for an aggressive form of the disease called acute myeloid leukemia (AML).http://medicalxpress.com/news/2013-08-tumor-suppressor-fuel-aggressive-leukemia.html
CancerTue, 27 Aug 2013 12:00:02 EDTnews296822555Study reveals much-needed strategy to protect against deadly liver fibrosisChronic liver disease is a leading cause of death in the United States, in part because it often causes the formation of harmful scar tissue—a process known as fibrosis. A study published by Cell Press August 15 in the journal Immunity reveals the central role the immune molecule interleukin 33 (IL-33) plays in the formation of liver fibrosis. The findings suggest that drugs targeting this molecule could serve as a new treatment strategy to protect against liver fibrosis.http://medicalxpress.com/news/2013-08-reveals-much-needed-strategy-deadly-liver.html
ImmunologyThu, 15 Aug 2013 12:00:01 EDTnews295761646Vanderbilt studies outline new model for staph bone infectionsOsteomyelitis, a debilitating bone infection most frequently caused by Staphylococcus aureus ("staph") bacteria, is particularly challenging to treat.http://medicalxpress.com/news/2013-08-vanderbilt-outline-staph-bone-infections.html
Medical researchThu, 01 Aug 2013 11:03:18 EDTnews294573787Potential cause of Parkinson's disease points to new therapeutic strategyBiologists at The Scripps Research Institute (TSRI) have made a significant discovery that could lead to a new therapeutic strategy for Parkinson's disease.http://medicalxpress.com/news/2013-07-potential-parkinson-disease-therapeutic-strategy.html
Parkinson's & Movement disordersWed, 24 Jul 2013 16:51:16 EDTnews293903458Cancer hijackGenetically unstable breast cancer cells appear to hijack a mechanism used by healthy stem cells to determine how they should develop into different tissues, according to new research.http://medicalxpress.com/news/2013-07-cancer-hijack.html
CancerFri, 19 Jul 2013 05:20:14 EDTnews293430003Self-perpetuating signals may drive tumor cells to spreadA team of international researchers from Duke-NUS Graduate Medical School Singapore and the Johns Hopkins University School of Medicine (USA) has identified a self-perpetuating signaling circuit inside connective tissue cells that allows these cells to form a front and a back and propel themselves in a particular direction over a long period of time. This propulsion is the same movement that tumor cells use to invade healthy tissue during cancer metastasis so cracking the code to this signaling network may lead to new therapeutic strategies against cancer and other devastating diseases.http://medicalxpress.com/news/2013-07-self-perpetuating-tumor-cells.html
CancerTue, 16 Jul 2013 16:09:41 EDTnews293209768Clinical trials for cancer, one patient at a timeColumbia University Medical Center (CUMC) researchers are developing a new approach to cancer clinical trials, in which therapies are designed and tested one patient at a time. The patient's tumor is "reverse engineered" to determine its unique genetic characteristics and to identify existing U.S. Food and Drug Administration (FDA)-approved drugs that may target them.http://medicalxpress.com/news/2013-07-clinical-trials-cancer-patient.html
CancerMon, 15 Jul 2013 13:39:56 EDTnews293114383Herding cancer cells to their deathAn advanced tumor is a complex ecosystem. Though derived from a single cell, it evolves as it grows until it contains several subspecies of cells that vary dramatically in their genetic traits and behaviors. This cellular heterogeneity is what makes advanced tumors so difficult to treat. Publishing their findings in today's online issue of Cancer Cell, an international team of scientists led jointly by Professors Colin Goding from the Ludwig Institute for Cancer Research who is based at the University of Oxford and José Neptuno Rodriguez-López from the University of Murcia, Spain describe a therapeutic strategy that manipulates a mechanism driving that heterogeneity to treat advanced melanoma. Their preclinical studies show that the strategy, which employs a new drug-like molecule in combination with an existing chemotherapy, is highly specific to melanoma cells and effective against tumors that resist all other therapies.http://medicalxpress.com/news/2013-06-herding-cancer-cells-death.html
CancerThu, 20 Jun 2013 12:59:50 EDTnews290951983A new model—and possible treatment—for staph bone infectionsOsteomyelitis – a debilitating bone infection most frequently caused by Staphylococcus aureus ("staph") bacteria – is particularly challenging to treat.http://medicalxpress.com/news/2013-06-modeland-treatmentfor-staph-bone-infections.html
Medical researchWed, 19 Jun 2013 14:47:57 EDTnews290872066Researchers discover new weapon in fight against cervical cancerScientists at the University of Leeds have found a way to target and destroy a key protein associated with the development of cervical and other cancers.http://medicalxpress.com/news/2013-05-weapon-cervical-cancer.html
CancerThu, 30 May 2013 17:16:27 EDTnews289152980Research shows how immune system peacefully co-exists with 'good' bacteriaThe human gut is loaded with commensal bacteria – "good" microbes that, among other functions, help the body digest food. The gastrointestinal tract contains literally trillions of such cells, and yet the immune system seemingly turns a blind eye. However, in several chronic human diseases such as inflammatory bowel disease (IBD), HIV/AIDS, cancer, cardiovascular disease, and diabetes, the immune system attacks these normally beneficial bacteria, resulting in chronic inflammation and contributing to disease progression.http://medicalxpress.com/news/2013-05-immune-peacefully-co-exists-good-bacteria.html
Medical researchWed, 22 May 2013 13:03:21 EDTnews288446557New perspective needed for role of major Alzheimer's gene(Medical Xpress)—Scientists' picture of how a gene strongly linked to Alzheimer's disease harms the brain may have to be revised, researchers at Washington University School of Medicine in St. Louis have found.http://medicalxpress.com/news/2013-05-perspective-role-major-alzheimer-gene.html
Medical researchTue, 07 May 2013 07:32:39 EDTnews287130751How some cancers 'poison the soil' to block metastasisCancer spread or metastasis can strike unprecedented fear in the minds of cancer patients. The "seed and the soil" hypothesis proposed by Stephen Paget in 1889 is now widely accepted to explain how cancer cells (seeds) are able to generate fertile soil (the microenvironment) in distant organs that promotes cancer's spread. However, this concept does not explain why some tumors do not spread or metastasize.http://medicalxpress.com/news/2013-04-cancers-poison-soil-block-metastasis.html
CancerTue, 30 Apr 2013 14:29:08 EDTnews286550938