Major glitches: Closed Photoshop CC 2015, opened again and image is completely ruined.

Hello, I started a new drawing today in CC2015 at 600ppi with 4 layers. I was using a Wacom tablet, which I regularly use without any issues. When I tried using the healing brush, it wasn't responding correctly; it was actually creating a clone tool-like effect. I double checked to make sure I was using the correct tool and tried it again -- same thing. Since it wasn't working, I used the paintbrush and smear tool to blend the colors instead.

A few minutes later I was working within a dotted line selection and using the paintbrush to add a color gradient to it. Instead of putting down opaque color, it exposed the layer behind it. Again, I made sure I wasn't using any tool but the paintbrush on normal setting, 100% opacity.

At this same time, when I would try to sample a color, it would take it from the lowest layer, not the one selected, unless I moved the cursor over part of the selected layer that didn't have any other layer information underneath it.

I decided to save the file and close, thinking it was a momentary glitch. When I opened the file again about an hour later, it looked completely glitched out.

Rectangular information is simply missing from each layer in the center, and there are other blocky sections missing from each one. The image is pretty much ruined.

The thumbnail in the folder on my mac reflects the bizarre changes as well. The attached screenshot shows the glitch-laden file. It looks nothing like the original.

Thanks for reading! I'm a high volume Photoshop user/ freelance illustrator and am wary of compromising my work by loading other files until I know they'll be safe. I need a solution that will allow me to continue to work and meet this week's deadlines. Please help!

Okay, thanks. If there's any particular setting that decreases the chances of it happening, would love to know about it. The image only looked slightly corrupted before I closed it. Guessing that the full corruption happened when I saved it the last time before closing PS? First tip off was seeing the thumbnail in the folder before reopening. Anyway, will make copies of in-progress files beforehand and hope for the best. Thanks for your responses.

Disabling GPU usage in Photoshop (then restarting the app) greatly reduces the chances of problems with the video card drivers. But it also disables any features that use the GPU. If you need the GPU features, then you may want to consider downgrading to a stable version of MacOS (10.9.5).

Ah I see -- thanks for that info. I'm attached to warp for sure in my PS use as well as some of the other GPU features, but it sounds like it may be worth a try. Did they give you any window on when the driver issues would be fixed and would it be part of a software update for Mac, PS, or both?

(The only other issue I've had lately is that certain psds that have been flattened and saved as jpegs cannot be opened again. As a user, this seems to randomly affect some files. I get the invalid marker error message. Was able to reopen them by saving them as psds again in Preview and then loading in PS. Not sure if this is related to the 10.10 issue as well.)