Publication Venue

We model oligomers of the Alzheimer's amyloid β-peptide Aβ(1-42) in an implicit membrane to obtain insight into the mechanism of amyloid toxicity. It has been suggested that Aβ oligomers are the toxic species, causing membrane disruption in neuronal cells due to pore formation. We use basin-hopping global optimization to identify the most stable structures… (More)

In this paper, we present an enhanced virtual observation therapy (VOT) system to address challenges in medication adherence and the current observed therapy approach. The original approach requires both patient and healthcare worker to be physically collocated, which has several technical and practical challenges. Therefore, we developed a system that… (More)