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Miguel O'Hara, a brilliant geneticist living in New York (renamed Nueva York) in the year 2099 A.D. attempts to recreate the abilities of the original Spider-Man in other people and later suffers a related accident that causes half his DNA to be re-written with a spider's genetic code.

In a post-credits scene, Lyla informs Miguel O'Hara of the crisis and is given his own dimension-hopping technology. He decides to "go back to the beginning" and ends up arguing with that universe's Spider-Man about who pointed first.

There are plan for a direct sequel and a female centered spin-off but no clear indication about Miguel reveled yet:

In an interview with Vanity Fair, Pascal confirmed the announced sequel to Spider-Verse is moving forward with Voltron: Legendary Defender showrunner Joaquin Dos Santos directing the film from a script written by David Callaham (Wonder Woman 1984). Pascal then revealed that the sequel would focus on Miles Morales and Earth-65's Gwen Stacy as their multiversal friendship develops into a romantic relationship.

Also in development is a planned spinoff for Spider-Gwen, which Pascal confirms will also introduce Silk and Jessica Drew's incarnation of Spider-Woman. The animated film is being written by Bek Smith with Lauren Montgomery (Batman: Year One) attached to direct.

Additionally, Pascal hints there may be tentative plans for the other heroes introduced in Into the Spider-Verse to star in their own animated spinoffs, including John Mulaney's Spider-Ham. "Of course! You can imagine how much the kids love that character," admitted Pascal.