angiogenin and ILK (show ILK Proteins) signaling pathway plays a pivotal role in mediating the inhibitory effects of RI on melanoma cells growth

Our data provide new insights into the paracrine activities of angiogenin in the nervous system, and further highlight the critical role of non-neuronal cells in the pathogenesis of Amyotrophic lateral sclerosis

RNase 4 (show RNASE4 Proteins) and RNase 5/ang 1 (show ANGPT1 Proteins) are unique among the RNase A (show RNASE1 Proteins) ribonuclease genes in that they maintain a complex gene locus that is conserved across species with transcription initiated from tissue-specific dual promoters followed by differential exon splicing.

ANG plays an important role in neurite pathfinding and this has implications for amyotrophic lateral sclerosis.

Angiogenin mRNA was expressed in murine skin in a hair-cycle dependent manner, with maximum levels observed at the late anagen.

Murine angiogenin mRNA and protein are upregulated in motoneurons in response to hypoxia, and that Hypoxia-Inducible Factor 1 (show HIF1A Proteins) is sufficient and required to upregulate angiogenin expression during hypoxia.

This study is the first to demonstrate that hypoxia upregulates Ang1 (show ANGPT1 Proteins) expression via HIF2alpha (show EPAS1 Proteins)-mediated transcriptional activation in pericytes, which plays a key role in angiogenesis.

bovine angiogenin is the substance mainly responsible for the inhibitory effect of bovine milk on osteoclast-mediated bone resorption

Angiogenin (ANG) Protein Profile

Protein Summary

The protein encoded by this gene is an exceedingly potent mediator of new blood vessel formation. It hydrolyzes cellular tRNAs resulting in decreased protein synthesis and is similar to pancreatic ribonuclease. Alternative splicing results in two transcript variants encoding the same protein. This gene and the gene that encodes ribonuclease, RNase A family, 4 share promoters and 5' exons. Each gene splices to a unique downstream exon that contains its complete coding region.