It is understood the male driver of the falcon has just finished a shift.

"We will be working with the employers of the companies to try and minimise the impact this would have on any other future movements of staff after they have finished work in and around that area," he said.

"It's very hard to know what sleep patterns occurred prior to the accident."

Inspector Muir said they will also be looking into possible distractions, "where that person was on the phone or looking for something else in the car".

It brings about the message of staying safe on the road.

"We would like to remind everyone to make sure you are well prepared for your trip," Inspector Muir said.

"Make sure you are properly rested.

"If you're feeling tired, stop and have a break, get out of your car, walk around."

The Fitzroy Developmental Rd has been subject to a number of crashes over the years, progressively more in the last few months.

"It's an isolated stretch of road, there is a lot of people that traverse in between mining areas and it's a shortcut from the north heading south," Inspector Muir said.

"It's one of those things where some people like to travel at night and these things happen.

"There is also a number of animals that can just jump out on the road when you least expect it and when you aren't concentrating you can crash."

UPDATE 12.30pm: A TWO-year-old girl critically injured in a Central Queensland crash has been flown to a Brisbane Hospital this afternoon.

A spokesperson from Rockhampton Hospital confirmed the infant who suffered serious head injuries in a "high speed" crash on Fitzroy Developmental Rd has been airlifted to Lady Cilento Children's Hospital in Brisbane.

RACQ Capricorn Helicopter Rescue originally flew the girl to Rockhampton around 9.22pm last night after a single-vehicle cash on the notorious stretch of highway.

A man in his 50s remains in a serious but stable condition in hospital after he also suffered critical injuries in the crash.

The man was taken to hospital with serious leg, chest and abdominal injuries.

A woman who escorted the infant girl to hospital has been discharged.

INITIAL STORY: AN INFANT is among those seriously injured in a crash on a notorious stretch of Central Queensland highway overnight.

Queensland Ambulance Service were called to the scene of a "high-speed collision" between two vehicles on the Fitzroy Developmental Rd at 9.22pm.

A spokesperson from QAS said the crash, 20km north of Dingo left four people injured- two critically.

RACQ Capricorn Helicopter Rescue were tasked to the crash at 9.55pm where the on-board flight medical crew provided assistance to a two-year-old female who suffered suspected head injuries from the collision.

The infant was immediately stabilised on scene before being flown to Rockhampton Hospital in a critical condition for further treatment.

The girl was also accompanied by her mother who had also suffered a suspected leg injury from the collision.