The trade agenda has undergone significant transformations during the last 25 years. Negotiations have moved from the reciprocal reduction of tariff barriers to include the construction and harmonization of regulatory frameworks in different policy areas, while trade liberalization has simultaneously advanced at the regional and multilateral levels.This research explores under what conditions the launch of trade negotiations - symmetric (South- outh), asymmetric (North-South), and multilateral - have a differential impact on domestic governance. Based on a systematic and contextualized comparative analysis of the complex constellation of domestic actors and interests, and the relationships and interactions established among them in a particular institutional setting, our study argues that these different trade agendas generate diverse policy dynamics. Findings show that the variation in the scope of the agenda, the uncertainty of political outcomes, and the technical requirements attached to these negotiations have important consequences for the ways in which domestic state and non-state actors define their interests and collective action strategies.