The roads taken to the Academy Awards are many, but they usually run through Toronto.

Every best picture winner since 2007 has played at the Toronto International Film Festival, from “No Country for Old Men” to last year’s winner, “Argo.” While other late summer festivals like Telluride can claim to have been first with many Oscar winners, Toronto is the largest, most expansive launch pad of the fall movie-going season.

This year’s festival, a 10-day affair beginning Thursday with the premiere of the WikiLeaks drama “The Fifth Estate,” with Benedict Cumberbatch as Julian Assange, promises to be no different. There are 146 feature films making their world premiere, including the highly anticipated adaptation of Tracy Letts’ Pulitzer Prize-winning play “August: Osage County,” with Meryl Streep and Julia Roberts; “Dallas Buyers Club,” with Matthew McConaughey as an industrious Texan diagnosed in the ’80s with HIV; and the kidnapping drama “Prisoners,” with Hugh Jackman and Jake Gyllenhaal.

“It’s like the major leagues. That’s how it feels,” says Gyllenhaal, who’s also premiering another film with “Prisoners” director Denis Villeneuve, the experimental Jose Saramago adaptation “Enemy.” ”It’s so big that it’s hard to have perspective.”

Many films that have just recently screened at Telluride or Venice will also come to Toronto, including Alfonso Cuaron’s space odyssey “Gravity,” with Sandra Bullock and George Clooney; Steve McQueen’s slavery epic “Twelve Years a Slave”; and Jason Reitman’s “Labor Day,” a drama about a mother’s (Kate Winslet) run-in with an escaped convict (Josh Brolin).

No awards are handed out at Toronto, but Academy Awards handicapping is rampant. Still, seeking an Oscar is far from the only motivation at one of the world’s most elite platforms for ambitious cinema, one laid out for both Hollywood industry frenzy and cinephile gluttony.

“A lot of that does begin in Toronto because our audience here has become known for having a good nose for quality films and finding films like ‘Slumdog Millionaire,’ ‘The King’s Speech,’ ‘Argo’ and ‘Silver Linings Playbook’ — even going back to ‘American Beauty’ in 1999,” says Cameron Bailey, TIFF artistic director. “I would hope that the attention is never limited to those films that might be in the horse race because there’s a lot more going on here.”

In addition to premieres of fall heavyweights such as Ron Howard’s Formula One drama “Rush” and the brawny, action-heavy biopic “Mandela: Long Walk to Freedom,” there are dozens of high-profile films seeking distribution deals with a Toronto premiere.

Matthew Weiner, the “Mad Men” creator,” will premiere “You Are Here,” a story about two longtime best friends played by Owen Wilson and Zach Galifianakis. For many filmmakers like Weiner, a premiere in Toronto is the culmination of years of work. He penned the script’s first draft in between seasons as a writer on “The Sopranos,” long before “Mad Men” made him famous.

“I am probably selfishly overwhelmed with the thought of having an audience see the movie for the first time,” says Weiner. “I have very high expectations not on its reception, necessarily, but on what will be going on emotionally for me.”

John Turturro was recently making a few final polishes on his “Fading Gigolo,” the rare film to lure Woody Allen back into acting. In Turturro’s comedy, which he wrote and directed, Allen plays pimp to Turturro’s novice male escort.

“He wanted it to be a smart film,” says Turturro of Allen. “It’s actually a delicate comedy. You can do a really broad comedy and sometimes they can sustain, but usually they run out of steam after 45 minutes.”

It’s the fifth film directed by the versatile Turturro, but there will be several first-time filmmakers at Toronto: Jason Bateman will present his directorial debut “Bad Words” and Mike Myers will debut his documentary “Supermensch: The Legend of Shep Gorden.”

Also among the notable films looking for distribution is the WWII POW tale “The Railway Man,” with Colin Firth and Nicole Kidman, and “Can a Song Save Your Life?” from “Once” director John Carney. Starring Mark Ruffalo and Keira Knightley, it’s about a down-on-his-luck music producer and an aspiring singer in New York.

Particularly current is Bill Condon’s “The Fifth Estate,” which premieres just weeks after the sentencing of one of WikiLeak’s greatest sources, Chelsea Manning (the Army private formerly known as Bradley Manning), and on the heels of the asylum drama of Edward Snowden, the leaker of NSA documents.

“Because these issues are so pressing and important, we all felt a responsibility to make sure that it was as complete a picture as possible,” says Condon. “Watching the Snowden story unfold has been strange because so many of the events are near what happened with Assange.”

Though Toronto is primarily a place where movies get their start, this year’s festival is full of endings. Two films co-starring the late “Glee” actor Corey Monteith will premiere: “All the Wrong Reasons,” in which he plays a department store manager, and “McCanick,” where he plays a felon on the run. Closing the festival will be “Life of Crime,” with Jennifer Aniston and John Hawkes, an adaptation of Elmore Leonard’s crime novel “The Switch.” The author died in August.

Ahead of its September release, the romantic comedy “Enough Said” will premiere from writer-director Nicole Holofcener, who unfortunately first came to TIFF with her “Lovely & Amazing” on Sept. 11, 2001. This year, she’ll be debuting one of the final films from James Gandolfini. He and Julia Louis-Dreyfus play divorced parents who meet at a party.

“It feels exciting and bittersweet, says Holofcener. “The whole release of the movie feels bittersweet to me because of Jim’s death. If he was coming with us to promote the movie and to open it with Julia and myself, it would be an all-around happy experience.”