Quote from the Anthony Zurcher report on the Republican Presidential debate in the USA as reported by the BBC online:

Cruz’s best moment likely came when he discussed his half-sister’s death of a drug overdose.

“This is an absolute epidemic,” he said of drug addiction in the US. “We need leadership to solve it.”

If this unaddressed addiction epidemic was just about drugs and alcoholic, though horrific enough, it might still be containable with current methodology.
Unfortunately for our global culture, this epidemic (a disease of corrupted leadership both individual and systemic) is at the core of the global financial paralysis, the global religious terrorism phenomena, the global obesity statistics, the global political disconnect.
If this epidemic continues unaddressed, the global constitutional condition as described by the connectivity of the diplomatic organs of the global body politic, this global body risks total collapse.
Simply seeing the connecting symptoms in a way that diagnoses the overall global situation within an illness paradigm to be healed, rather than an intellectual problem that has to be politically solved, would release a massive surge of creative and cohesive energy.