The Nature Conservancy purchased an 11,255.51-acre core tract from the Fisher Lumber Company, a subsidiary of General Motors Corporation. The Conservancy then sold the land to the USFWS over a span of 5 years.

Cocodrie Bayou is designated as a state scenic river.

The bottomland hardwoods at Bayou Cocodrie NWR have been noted as some of the last remaining, least disturbed timber in the Mississippi River Delta.

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