InÃs Barroso, SANGER-IB

Dr InÃs Barroso

Role and
contribution

Dr Barroso contributes to the selection of genes
and SNPs and to the analysis of main genetic effects and gene-lifestyle
interaction (WP3.1,3.4)

â
Scientific profile

InÃs has 13 years experience in studies of human
disease. She spent 6 years in the biotechnology sector (at Hexagen, later
acquired by Incyte Genomics), performing experiments and directing research
programmes in the field of genomics and genetics of complex disease (type 2
diabetes and obesity). At Incyte she was a Director responsible for the type 2
diabetes target validation programme and was the scientific leader of the
genetics projects within this programme.â
She is currently a Faculty member at The Wellcome Trust Sanger Institute
where she directs a team focused on understanding the genetic aetiology of type
2 diabetes, obesity and related metabolic traits.â The group is working on the identification of
genetic mutations that lead to uncommon extreme forms of disease (extreme insulin
resistance, morbid childhood obesity and MODY).â
In the past few years most of the approach focused on candidate gene
based studies but with the completion of the HapMap project and the
availability of adequately sized and carefully phenotyped sample collections
these studies now encompass genome-wide association studies of obesity and type
2 diabetes.