Data suggest that expression of SLC1A1 in intestinal epithelial cells can be regulated by dietary components; expression of SLC1A1 is up-regulated by L-glutamate (show GRIN2C ELISA Kits), an abundant dietary amino acid and dietary supplement.

These findings indicate that the expression of the EAAC1 in jejunum is much depending on the stage of piglet development and that low BW at birth is associated with lower expression of this carrier in the early suckling period.

Glutamate (show GRIN2C ELISA Kits) uptake across apical membrane is regulated by changing expression of EAAC-1 at transcription and translation levels as well as maximal uptake activity and transporter affinity along the intestinal crypt-villus axis in the neonate.

Antigen Summary

This gene encodes a member of the high-affinity glutamate transporters that play an essential role in transporting glutamate across plasma membranes. In brain, these transporters are crucial in terminating the postsynaptic action of the neurotransmitter glutamate, and in maintaining extracellular glutamate concentrations below neurotoxic levels. This transporter also transports aspartate, and mutations in this gene are thought to cause dicarboxylicamino aciduria, also known as glutamate-aspartate transport defect.

Alternative names and synonyms associated with Solute Carrier Family 1 (Neuronal/epithelial High Affinity Glutamate Transporter, System Xag), Member 1 (SLC1A1)