Genetics

Abstract

The genetic organization of Vibrio cholerae 01 has been investigated by a variety of classical and molecular genetic techniques. The genetic complement of this species includes plasmids, bacteriophage, and insertion sequences; however, all virulence factors so far examined are encoded on a chromosome of ca. 2.8 × 103 kb.1 The basic features of gene structure, transcription, translation, regulation, and genetic exchange are similar to those found in common enteric bacteria, and V. cholerae 01 readily exchanges genetic information via conjugative plasmids with these organisms.2,3