RT Journal
A1 Antonen J, Hulkkonen J, Pasternack A, Hurme M
T1 INterleukin 6 may be an important mediator of trimethoprim-induced systemic adverse reaction resembling aseptic meningitis
JF Archives of Internal Medicine
JO Archives of Internal Medicine
YR 2000
FD July 10
VO 160
IS 13
SP 2061
OP 2067
DO
UL http://dx.doi.org/
AB
Moris and Garcia-Monco1 recently presented an excellent review on drug-induced aseptic meningitis in the ARCHIVES. As they pointed out, the pathogenesis of the reaction is unknown. We have recently published a report on a series of 12 patients with a history of trimethoprim-induced systemic adverse reactions closely resembling aseptic meningitis.2 Among that group, treatment with trimethoprim in vitro induced substantial interleukin 6 (IL-6) production, but no IL-1, tumor necrosis factor α (TNF-α), or IL-2 in the purified peripheral blood mononuclear cells. In support of those findings, we report a case of a trimethoprim-induced aseptic meningitis-like reaction, in which cytokines from blood and cerebrospinal fluid (CSF) were measured.