Post-streptococcal glomerulonephritis (GN)

Post-streptococcal glomerulonephritis (GN) is a disorder of the kidneys that occurs after infection with certain strains of Streptococcus bacteria.

Causes of Post-streptococcal glomerulonephritis (GN)

Post-streptococcal GN is a form of glomerulonephritis. It is caused by an infection with a type of streptococcus bacteria. The infection does not occur in the kidneys, but in a different part of the body, such as the skin or throat.

The strep bacterial infection causes the tiny blood vessels in the filtering units of the kidneys (glomeruli) to become inflamed. This makes the kidneys less able to filter the urine.

Post-streptococcal GN is uncommon today because infections that can lead to the disorder are commonly treated with antibiotics. The disorder may develop 1 - 2 weeks after an untreated throat infection, or 3 - 4 weeks after a skin infection.

It may occur in people of any age, but it most often occurs in children ages 6 - 10. Although skin and throat infections are common in children, post-streptococcal glomerulonephritis is a rare complication of these infections.

Tests and Exams

A physical examination shows swelling (edema), especially in the face. Abnormal sounds may be heard when listening to the heart and lungs with a stethoscope (auscultation). Blood pressure is often high.