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On a synth, they're pretty much the same thing, depending on how you play it.

They're both relatively constant, maintaining a sound bed underneath your melodic & rhythmic structure. They don't have any kind of 'spiky' or rhythmic essence to them - slow, drifting, would best describe them.

Essentially, though, a drone never changes note[s] - like the drones on bagpipes or hurdy-gurdy etc - so you have to really play in a single key.