Sooner or later, the Padres are going to win a game against the Phillies at Petco Park.

But Friday night could be difficult for the hosts as Rancho Bernardo High grad opens for the Phillies (7:05 p.m.; TV: Fox San Diego; Radio: 1090-AM).

There will be fireworks after the game.

The question is, will there be any fireworks during the game?

The Padres are 1-3 against Hamel at Petco Park and 2-6 overall. The Padres have a .179 lifetime batting average against Hamels. They reach base about 23 percent of the time against the Phillies left-hander.

Overall, the Phillies have won 12 straight games against the Padres at Petco Park – a Phillies franchise record for any opposing ballpark. They are 23-4 in San Diego since Petco Park opened in 2004.

The Padres will open with Chris Denorfia in the leadoff slot for the first time this season. Andy Parrino will be back in the lineup at short.

PHILLIES (6-7) at PADRES (3-11)

Time: 7:05 p.m. / Game 2 of 4

TV: Fox San Diego

Radio: 1090-AM; 860-AM (Spanish)

PITCHING MATCHUP

Phillies vs. LHP Cole Hamels (1-1, 3.65 ERA)

Hamels vs. the Padres: 6-2, 2.28 ERA in 11 starts

Hamels at Petco Park: 3-1, 1.23 ERA in five starts

Hamels, 28, was a first-round pick (17th overall) of the 2002 draft out of Rancho Bernardo High. The Padres have a career .179 batting average and .226 on-base percentage against Hamels. Hamels was 14-9 last season with a 2.79 ERA and finished fifth in the National League Cy Young Award voting.

Padres vs. Hamels

Yonder Alonso: .000 (0-for-2, SO)

John Baker: .000 (0-for-6, 2 SO)

Jason Bartlett: .143 (1-for-7, 2 SO)

Chris Denorfia: .000 (0-for-5, BB, 3 SO)

Jesus Guzman: .000 (0-for-3, SO)

Chase Headley: .211 (4-for-19, 2B, 4 SO)

Jeremy Hermida: .211 (4-for-19, HR, 4 SO)

Orlando Hudson: .200 (4-for-20, 2B, 7 SO)

Nick Hundley: .200 (1-for-5, HR, BB, SO)

Mark Kotsay: .250 (1-for-4)

Cameron Maybin: .316 (6-for-19, 3 2B, 5 SO)

Will Venable: .200 (1-for-5, BB, 2 SO)

Padres RHP Edinson Volquez (0-1, 4.24 ERA)

Volquez vs. the Phillies: 2-0, 0.73 ERA in three starts

Volquez at Petco Park:

Volquez, 28, Half the eight runs scored against Volquez in his first three starts have come in the first inning. Last season in Cincinnati, he gave up 24 runs in the first inning of his 20 starts. His ERA in the first this year is 12.00 and after the first is 2.57. He is 0-1 with a 3.00 ERA in two starts at Petco Park.