“ In 112 BC Antiochus VIII defeated his stepbrother and rival Antiochus IX Cyzicenus, and took Antioch, where Cleopatra IV, the wife of Antiochus IX, stayed. Tryphaena hated her sister Cleopatra IV, who had taken refuge in the temple of Apollo, and wanted her to be killed. She accused Cleopatra IV of introducing foreign armies into the dispute between the Seleucid stepbrothers and marrying outside Egypt against the will of her mother.

Antiochus VIII tried in vain to dissuade his wife; who got her sister executed despite his refrain that their ancestors had not dealt violently with women. Before dying Cleopatra IV cursed her murderers; leaving her revenge to the Greek gods.

A year later (111 BC) Tryphaena was taken prisoner by Antiochus IX after he had beaten his stepbrother in another battle. Antiochus IX then had her executed.”

If you’re referring to the most popular Cleopatra(with Caesar and Mark Antony); according to historians; she came later(Cleopatra VII Philopator born in Alexandria; 69 B.C.)