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So how exactly does Testosterone Propionate build muscle? Testosterone Propionate promotes nitrogen retention in the muscle , and the more nitrogen the muscles hold the more protein the muscles store, and the bigger the muscles get. Testosterone Propionatecan also increase the levels of another anabolic hormone, IGF-1, in muscle tissue. IGF-1 is alone highly anabolic and can promote muscle growth. It is responsible for much of the anabolic activity of Growth Hormone (GH). IGF-1 is also one of the few hormones positively correlated with both muscle cell hyperplasia and hyperphasia (this means it both creates more muscle fibers as well as bigger fibers). All of this might lead one to speculate that for pure mass, IGF-1, HGH, and Testosterone Propionate would be a very effective combination. Testosterone Propionate also has the amazing ability to increase the activity of satellite cells. These cells play a very active role in repairing damaged muscle. Testosterone also binds to the androgen receptor (A.R.) to promote all of the A.R dependent mechanisms for muscle gain and fat loss , but clearly, as we've seen, this isnt the only mechanism by which it promotes growth.