Panobinostat (LBH-589) is a member of the hydroxamic acid group of histone deacetylase (HDAC) inhibitors that have been shown to impede multiple pathways implicated in cancer and reverse epigenetic events associated with cancer, thereby reducing survival and inducing apoptosis in cancer cells. Panobinostat is being investigated in various hematological malignancies, including chronic myelogenous leukemia (CML) and multiple myeloma, and in solid tumors.