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The AmoyDx KIT D816V Mutation Detection Kit is a sensitive and selective assay for the detection of the D816V mutation in the KIT gene.

KIT is a receptor tyrosine kinase (RTK) that normally plays a critical role in hematopoiesis. Mutation of the KIT gene leads to aberrant growth signaling in the cell harboring the mutant protein. KIT mutations have been associated with several malignancies, including acute myeloid leukemia (AML), gastrointestinal stromal tumors (GIST), and testicular carcinomas. The most common mutation of KIT in these disorders is a substitution of the aspartic acid residue in position 816 with a valine (D816V), leading to constitutive activation of the receptor.

Intended Use: For research purpose use only. This kit is used to detect the KIT D816V mutation in the DNA samples.