• The risk of cardiovascular disease increases progressively and continuously with increases in systolic or diastolic blood pressure, approximately doubling for every 20/10 mm Hg incremental increase in blood pressure that occurs within the range of 115/75 to 185/115 mm Hg.

Development of malignant hypertension during a 12-month period. Systolic and diastolic arterial pressures of Franklin D. Roosevelt 1935-1941 and in the year before his death due to cerebral hemorrhage on April 12, 1945. MICHAEL F. O’ROURKE et al. Mayo Clin Proc. 2006;81(8):1057-1068

TROPHY study
• Over a period of 4 years, 2/3 of placebo group developed stage 1 hypertension • Treatment of prehypertension with candesartan reduced the risk of incident hypertension during the study period.