Okay, I finally figured this out and it was so obvious. I tried all of the tips mentioned below and nothing worked. When I happened to stumble upon an option in iTunes. 1. Plug your device into the computer running iTunes.2. Click on the device name in the iTunes sidebar.3. On the Summary tab, scroll down.4. You should see an "Options" section and an option in the list named "Enable sync over wifi" or something like that.5. Check that box and click the Apply button in the bottom-right corner.6. Wait for your device to finish syncing.

My "Sync Now" button is also greyed out after trying all suggested steps. I have another problem (Itunes store will not load. Just shows a white window with a few blue hyperlinks at best, even after several re-installations of itunes 10.5) which forced me to download an album from itunes using my iphone 4. After 15 minutes or so I went to sync my iphone to my PC using the cable but noticed itunes was in the final stages of syncing the new album to my PC. Both my PC and iphone were using my home wifi, but "sync now" still grey, and my iphone was not listed in itunes left window! Work that one out!

I have an idea for a solution because I ran into a problem once where I couldn't open any programs at all on my computer. For whatever reason I couldn't run anything unless I right clicked on the program and selected "run as administrator" from the list.

To always run iTunes as administrator:

1. Right click on the iTunes shortcut on your desktop or in your start menu

2. Click properties

3. Click the Compatibility tab

4. At the bottom there should be a checkable box with the text "Run this program as an administrator", make sure it's checked

I'm not saying this will work for everyone and I'm sure somebody will come up with a universal fix someday, but this is what worked for me.

"On your phone go to Settings>Wi-Fi and then press the little blue/white arrow on the far right of your network name, scroll down and then press renew lease. I tried it once and it didn't work, but I then spammed it over over over again and after about 4 or 5 times i tried the Wi-Fi sync again, and it worked!"

Incoming Links

This site contains user submitted content, comments and opinions and is for informational purposes only.
Apple may provide or recommend responses as a possible solution based on the information provided; every potential issue may involve several factors not detailed in the conversations captured in an electronic forum and Apple can therefore provide no guarantee as to the efficacy of any proposed solutions on the community forums.
Apple disclaims any and all liability for the acts, omissions and conduct of any third parties in connection with or related to your use of the site. All postings and use of the content on this site are subject to the Apple Support Communities Terms of Use.