For the Media

Columbia Research Suggests More Targeted Treatment, Prevention is Warranted

NEW YORK (January 13, 2010) – Latinos are not all the same when it comes to risk of heart disease, and a new study by a Columbia University researcher shows key differences among Hispanic populations that doctors should take into account in trying to stem the risk of cardiovascular disease in this large and growing subset of the U.S. population.

Among the new findings published in the January 19, 2010 Journal of the American College of Cardiology are that Caribbean-origin Hispanics have greater prevalence of hypertension than Mexicans, whom among all the Hispanic subgroups tended to be more susceptible to diabetes, lead cardiologist/researcher Carlos Rodriguez, M.D., MPH, of Columbia University Medical Center and his colleagues have found.

Hispanics are the largest minority ethnic group in the United States, numbering 46 million people or 16 percent of the U.S. population. Sixty-seven percent of Hispanics in the Uniteds States are of Mexican origin, 19 percent come from the Caribbean (principally from Puerto Rico, Cuba, and the Dominican Republic), and 14 percent originate from Central and South America, according to federal data.

Carlos Rodriguez, M.D.
The study examined left-ventricular hypertrophy and cardiac “remodeling” patterns with the help of magnetic resonance imaging (MRI) in Hispanic subgroups compared with non-Hispanic whites participating in the Multi-Ethnic Study of Atherosclerosis or MESA, which was conducted in six cities across the United States. Dr. Rodriguez conducted this research as a scholar with the Harold Amos Medical Faculty Development Program, a national program of the Robert Wood Johnson Foundation.

Cardiac remodeling refers to the changes in size and shape, of the heart when it is subject to repeated stress from high blood pressure or diabetes or volume overload. Cardiac hypertrophy and remodeling have been shown to be a strong risk factor for future heart attacks, stroke and death.

With higher rates of hypertension, Caribbean-origin Hispanics have a higher prevalence abnormal hypertrophy compared with non-Hispanic whites, the study found. A higher prevalence of cardiac hypertrophy and abnormal left-ventricular remodeling was also observed among Hispanics from Mexico, despite a lower prevalence of hypertension in that population, Dr. Rodriguez and his colleagues demonstrate. These results persisted after adjustment for high blood pressure and diabetes suggesting that these risk factors only partially explain these findings.

“An important finding that doctors should take note of is that Hispanics are not monolithic with respect to cardiovascular risk factors,” Dr. Rodriguez says. “Different subgroups originating in different geographic areas of Latin America manifest significant differences in the way their hearts handle stress from underlying conditions or disease. It is interesting that despite these differences, a high prevalence of cardiac hypertrophy and cardiac risk was present among all the Hispanic subgroups.”

The research from Columbia, funded in part by the Harold Amos Medical Faculty Development Program of the Robert Wood Johnson Foundation and the National Heart, Lung, and Blood Institute, is the first comparative analysis of Hispanic subgroups in a single cohort to demonstrate differential prevalence of hypertension and diabetes and relate them to cardiac structure across Hispanic subgroups, which illustrates the heterogeneity of the Hispanic population.

“When considering heart disease in minority populations, it is important for doctors to weigh crucial distinctions among Hispanic groups,” Dr. Rodriguez says. “We need to better appreciate, understand and address differences among Hispanic ethnic subgroups to prevent adverse cardiovascular events in this population.”

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Columbia University Medical Center provides international leadership in basic, pre-clinical and clinical research, in medical and health sciences education, and in patient care. The medical center trains future leaders and includes the dedicated work of many physicians, scientists, public health professionals, dentists, and nurses at the College of Physicians and Surgeons, the Mailman School of Public Health, the College of Dental Medicine, the School of Nursing, the biomedical departments of the Graduate School of Arts and Sciences, and allied research centers and institutions. Established in 1767, Columbia’s College of Physicians & Surgeons was the first institution in the country to grant the M.D. degree and is now among the most selective medical schools in the country. Columbia University Medical Center is home to the largest medical research enterprise in New York City and state and one of the largest in the United States. For more information, please visit www.cumc.columbia.edu.

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