Acetylated Low Density Lipoprotein (AcLDL) is taken up by cells via scavenger receptors and has been used as a mechanism of targeted drug delivery and in combination with saporin for the depletion of specific cell types. AcLDL behaves like oxidised LDL, both of which are degraded within lysosomes.

Native oxidized Low Density Lipoprotein from human plasma. Low density lipoprotein (LDL) oxidative modification is one of the major processes involved in atherosclerosis along with other degenerative disorders. Oxidised LDL is preferentially accumulated by macrophages which become so called "foam cells" within the atheromatous plaque and contributes to the accumulation of cholesterol, typical of atherosclerosis.

This product was prepared from normal serum by a multi-step process which includes delipidation, salt fractionation, ion exchange chromatography followed by papain digestion and extensive dialysis against the buffer stated above. Assay by immunoelectrophoresis resulted in a single precipitin arc against anti-biotin, anti-Human Serum, anti-Human IgG and anti-Human IgG F(c). No reaction was observed against anti- Human IgG F(ab')2 or anti-Papain.

This product was prepared from normal serum by a multi-step process which includes delipidation, salt fractionation and ion exchange chromatography and papain digestion followd by chromatographic seperation and extensive dialysis against the buffer stated above. Assay by Immunoelectrophoresis resulted in a single precipitin arc against anti-Human Serum, anti-Human IgG and anti-Human IgG F(c). No reaction was observed against anti- Human IgG F(ab')2 or anti-Papain.

High Density Lipoprotein (HDL) is a complex that transports cholesterol in the blood to the liver. It is the smallest and densest of the lipoproteins as it contains the highest proportion of protein. It is thought that high levels of HDL can help to remove cholesterol from atheroma in the arteries thereby decreasing the risk of heart disease.

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