The 31-year-old had to watch the remainder of the game from the sidelines as fellow Frenchman Antoine Griezmann scored twice in the Spanish side's 3-0 win.

The former West Ham United playmaker was a key figure in France's run to the Euro 2016 final, although he has not featured for the national team since 10 October.

Payet had made a strong bid for a recall to the international stage with an impressive run of form, which included inspiring Marseille to the Europa League final, but his injury may have ended his chances of playing in the tournament.

France manager Didier Deschamps is set to announce his squad on Thursday.