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Depression

Preface: In 1998, I introduced the term dysox—short for dysoxygenosis—for the state of fundamental failure of energy generation and detox in the cells. I showed that dysox is caused by impaired function of enzymes involved in oxygen-driven chemistry (“oxyenzymes”) and leads to the buildup of acids and toxins in the body.

When you see dysox – think of a state of acidity and toxicity in your body.

When you see oxygen dysfunction – think of the body’s use of oxygen to create energy and the various chemical signalling our bodies require to make chemical reations happen.

Depression is an energy disorder. More precisely a brain energy disorder.

Lack of energy is a problem of a dysfunction in oxygen, brain dysox (too much acid and txins in the brain) to be precise. Coenzyme Q10 is crucial for oxygen-driven ATP energy in the brain cells. So, it follows that Q10 supplementation should be considered as high priority for individuals with depression.

I recommend a daily dose of 450 to 750 mg. The best way to take Q10 is in the form of a lozenge to be taken during exercise.

The Oxygen Model of Depression

In the above paragraphs a very simplified view is presented as am outline. Oxygen and depression can be a hard to understand sugject. My Oxygen Model of Depression is an extension of my Oxygen Model of Health and Disease. It is a unifying model that explains all aspects of depression—causes, clinical course, consequences, and control—on the basis of disturbed oxygen function.

In deliberations of depression, the issues of excess acidity, increased oxidative stress, and clotting-unclotting dysequilibrium are seldom, if ever, duly considered.

What is the clotting-unclotting dysequilibrium?
I coined the term clotting-unclotting equilibrium (CUE) for a healthful state of the circulating blood when the unclotting process efficiently dissolves microclots formed in the blood so that such clots do not accumulate. The clotting-unclotting dysequilibrium (CUD) is my term for a “dis-ease” state of the circulating blood in which excessive microclot formation exceeds the body’s unclotting capacity. The unclotting process cannot efficiently dissolve microclots formed in the blood, so such clots begin to accumulate.

As stated in deliberations of depression, the issues of excess acidity, increased oxidative stress, and clotting-unclotting dysequilibrium are seldom, if ever, duly considered.

This is a serious mistake. My oxygen models of various diseases predict that ongoing research will reveal that components of acidosis (excess acidity), oxidosis (increased oxidative stress), and CUD (clotting-unclotting dysequilibrium) will be found to play important roles in the pathology and clinical features of the disease under consideration. Depression in all its forms represents a spectrum of a disease, and so is not an exception to the rule.

There is a growing body of evidence that depression is associated with oxidative stress, nitrosative stress, and abnormal inflammatory responses. Predictably, the blood levels of CoQ10 are lower in individuals with depression. The Oxygen Model of Depression predicts the clinical benefits of Q10 Supplementation. That has been my clinical experience.

Antidepressant Benefits of Coenzyme Q10

I want to point out that the antidepressant effects of Q10 supplementation can be vastly improved by adding to this supplementation other brain-nutrient nutrients, herbs, and spices. The following is the list of my top recommendations:

4. Dr. Ali’s Peroxide Oxygen Therapies (Foot Soaks and Baths)
The soaks can be done for the hands or feet at 20-30 minutes each soak. The soaks may be done at different concentrations of hydrogen peroxide. Any suitable vessel can be used for the soak. If possible, an electric foot bath may be used for additional benefits.

Dr. Ali’s Ginger-Walnut Oxygen Protocol
Once daily five days a week for chronic inflammatory, immune, and infectious disorders

Ginger root One inch long, one inch wide
Walnuts Two (shelled)
Olive oil 1/3 teaspoon
Stevia Lightly sprinkled to taste
(agave, xylitol or erythritol as sweetners may be used infrequently)

Grate ginger root and cut into pieces shelled walnuts. Add olive oil. Mash them with a masher and sprinkle a small amount of stevia. The ingredients can be increased or decreased according to their effects on symptoms of pain, soreness, and swelling. Stevia or other sweeteners decrease pungency of ginger.

L-glutamine is an important brain nutrient. It is commonly available from health food stores. White poppy seeds improve the quality of sleep and reduce anxiety and stress on the nervous system. Together these two natural substances increase the benefits of each other. I prescribe them for my patients as a protocol described below:

Poppy seeds can be ground into powder, mixed with glutamine powder, and kept in a jar. The required amount of this mixture can be added to yogurt or keifer just before taking it. The ingredients can be increased or decreased according to their effects on sleep, mood, and mental functions. Yogurt can be of cow milk or goat milk. Keifer can be used instead of yogurt.

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Healing Seminar 9 – Oxygen Model of Health and Disease
Professor Majid Ali presents his Oxygen Mode of Health and Disease and Oxygen Model of Disease. He speaks about his journey of a surgeon-turned-pathologist-turned-immunologist-turned-nutritionist-turned-ecologist-turned-“energy physician.” His unifying oxygen models are based on his evolutionary perspective of health, disease, and healing.

Healing Seminar 10 – Acid-Alkali Balance
Professor Majid Ali explains the importance of acid-alkali balance in health preservation and the reversal of chronic disease. In his evolutionary perspective, he recognizes oxygen as the ultimate regulator of this balance. He cautions against too much reliance on the values of pH (acidity indicator) in blood, urine, and saliva samples, since these samples reflect the body’s responses to threats to the balance.

Healing Seminar 11 – Oxidant – Antioxidant Regulation
Professor Majid Ali presents the scientific facts of oxidant-antioxidant regulation, beginning with definitions of terms and simple explanation of natural processes called oxidation (loss of electron energy) and reduction (gain of electron energy) with simple analogies. Next he shows how oxygen regulates oxidant-oxidates reactions and why oxidant therapies are more important than antioxidant therapies.

In this DVD video seminar, Prof. Ali describes his guidelines for gentle daily bowel detox and colon cleanse. He explains the advantages of this approach over intense one-week to 3-week programs which, notwithstanding their temporary benefits, often create adverse effects programs bowel.

Colon Diverticulosis and Diverticulitis Seminar One In this 35-minute part 1 of his Crohns Colitis Seminar, Professor Majid Ali, M.D. discusses the causes, signs and symptoms, pathology, clinical course, and consequences of colon diverticulosis and diverticulosis. He focuses on the issues of stress, unhealthy foods, colon fermentation, and bacterial infections.

Colon Diverticulosis and Diverticulitis Seminar Two
In this 35-minute part 2 of his Crohns Colitis Seminar, Professor Majid Ali, M.D. continues with his discussion of his evolutionary perspective of colon diverticulosis and diverticulosis. He focuses on the issues of stress, unhealthy foods, colon fermentation, and bacterial infections. He describes nondrug management plans for prevention of attacks of diverticulitis.

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In this 40-minute video seminar, Professor Majid Ali, M.D. discusses the causes, clinical features, and natural remedies for constipation. He presents his holistic, integrative, and ecologic view of the physiology and pathology of the alimentary tract and the bowel transit time. His recommended natural remedies are simple and low-cost. He offers other video seminars giving detailed information on the subjects covered.

Crohns Colitis Seminar One
In this 35-minute Seminar, Professor Majid Ali, M.D. discusses the causes, signs and symptoms, clinical course, and consequences of Crohns Colitis. He focuses on the issues of mold and food allergy, inflammatory factors, environmental pollutants that cause chronic inflammation in various segments of the alimentary tract, as well as organs, such as skin, eyes, and joints.

Crohns Colitis Seminar Two
In this 35-minute part 2 of his Crohns Colitis Seminar, Professor Majid Ali, M.D. continues his discussion of pathology of Crohns Colitis. He describes his integrative plan for addressing issues of mold allergy, food allergy, inflammation, leaky gut state, and abnormal immune responses for healing the bowel and preventing recurrences.

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In this 40-minute video seminar, Professor Majid Ali, M.D. describes and explains serious errors of the so-called H. Pylori infections and ulcers. He informs that H. Pylori microbe is part of the normal stomach flora and its presence must not be accepted as an indication of antibiotic therapy. Indeed, children without this microbe as a part of the stomach flora have much incidence of asthma, eczema, and other immune disorders than children who do have this microbe. Prof. Describes his unifying Oxygen Model of Gastritis and GERD and looks at the disease in a broad evolutionary perspective. This model is the basis of his rational and scientifically sound plan to control and reverse lupus with simple, safe, and effective natural therapies.

Spastic ColonIn this 40-minute video seminar, Professor Majid Ali, M.D. describes signs and symptoms of spastic colon and irritable bowel syndrome. He explains how neglected food allergy and mold allergy, and the problems caused by sugar and antibiotic abuse disrupt colon ecology and irritate the bowel. The irritated bowel literally becomes “spastic.” He cautions against the use of drugs without addressing these factors. Then explains his guidelines of controlling gut fermentation and leaky gut state,and for restoring the bowel health.

Stomach Fermentation, Gastritis, GERD, and Gastric Ulcer Seminar
In this 40-minute video seminar, Professor Majid Ali explains how fermentation occurs in the stomach and sets the stage for the development of gastritis, GERD, and stomach ulcers. Chronic inflammatory and immune disorders involving the colon, small intestine, stomach, esophagus, and the oral cavity are the consequences of fermentation.

Ulcerative Colitis Seminar One
Professor Majid Ali, M.D. discusses the causes, signs and symptoms, pathology, clinical course, and consequences of ulcerative colitis. He presents his evolutionary, microscopic, and clinical perspective on this chronic inflammatory disorders. He focuses on the issues of mold and food allergy, gut fermentation, stress, unhealthy foods, colon fermentation, stomach fermentation, and bacterial infections. In Part Two of this seminar, he describes his nondrug treatment approaches to effectively address all aspects of ulcerative colititis.

Ulcerative Colitis Seminar Two
In this 35-minute part 2 of his Crohns Colitis Seminar, Professor Majid Ali, M.D. discusses the causes, signs and symptoms, pathology, clinical course, and consequences of ulcerative colitis. He presents his evolutionary, microscopic, and clinical perspective on this chronic inflammatory disorders. He focuses on the issues of mold and food allergy, gut fermentation, stress, unhealthy foods, colon fermentation, stomach fermentation, and bacterial infections. In Part Two of this seminar, he describes his nondrug treatment approaches to effectively address all aspects of ulcerative colititis.

Healing Seminar 9 – Oxygen Model of Health and Disease
Professor Majid Ali presents his Oxygen Mode of Health and Disease and Oxygen Model of Disease. He speaks about his journey of a surgeon-turned-pathologist-turned-immunologist-turned-nutritionist-turned-ecologist-turned-“energy physician.” His unifying oxygen models are based on his evolutionary perspective of health, disease, and healing.
● Healing Seminar 10 – Acid-Alkali Balance
Professor Majid Ali explains the importance of acid-alkali balance in health preservation and the reversal of chronic disease. In his evolutionary perspective, he recognizes oxygen as the ultimate regulator of this balance. He cautions against too much reliance on the values of pH (acidity indicator) in blood, urine, and saliva samples, since these samples reflect the body’s responses to threats to the balance.● Healing Seminar 11 – Oxidant – Antioxidant Regulation
Professor Majid Ali presents the scientific facts of oxidant-antioxidant regulation, beginning with definitions of terms and simple explanation of natural processes called oxidation (loss of electron energy) and reduction (gain of electron energy) with simple analogies. Next he shows how oxygen regulates oxidant-oxidates reactions and why oxidant therapies are more important than antioxidant therapies.● Healing Literacy
In this 50-minute video seminar, Professor Majid Ali, M.D. presents the anatomy, physiology, and an evolutionary view of the pathology of cell membranes. Specifically, he focuses on the structures and functions of cell membrane receptor proteins, hormone receptors, and cell communication molecules. He then presents his “The grease and Detergent Model of Health and Disease.● Endo Literacy Seminar Part 2
In this video seminar, Professor Majid Ali focuses on the crucial importance of understanding the anatomy, physiology, and pathology of endo cells (short for endothelium cells) that line the interior of vascular and lymmphatic channels in the body. He explains how no chronic disease can be understood or treated with natural therapies without a clear understanding endos.● Cell Membrane Literacy – Course on Healing Intermediate Part 3
In this 50-minute video seminar, Professor Majid Ali, M.D. presents the anatomy, physiology, and an evolutionary view of the pathology of cell membranes. Specifically, he focuses on the structures and functions of cell membrane receptor proteins, hormone receptors, and cell communication molecules. He then presents his “The grease and Detergent Model of Health and Disease.● Matrix Literacy Part 4
In this 30-minute video seminar, Professor Majid Ali, M.D. informs us that in 1958 in medical school, he was taught to consider the matrix as the “cement” that holds the “bricks” of cells. He explains why he considers this analogy misleading. In reality, the matrix regulates most cellular functions. In his “Oxygen’s 3 M Model of Health and Disease, M1 refers to mito (mitochondria), the second M to membrane of cells, and the third M to the matrix. At the structural level, this models offers the foundational knowledge of cellular health and disease