BACKGROUND: We examined survival associated with locally advanced esophageal squamous
cell cancer (SCC) to evaluate if treatment without surgery could be considered adequate.
STUDY DESIGN: Patients in the Surveillance, ...

PURPOSE: Gliomas are one of the most fatal malignancies, with largely unknown etiology.
This study examines a possible connection between glioma and melanoma, which might
provide insight into gliomas' etiology. METHODS: ...

OBJECTIVE: Recently, the role of β-blockers (BBs) in reducing perioperative mortality
has been challenged. The conflicting results might have resulted from the extent of
BB metabolism by the cytochrome P-450 (CYP2D6) isoenzyme. ...

The observed bimodal patterns of breast cancer incidence in the U.S. suggested that
breast cancer may be viewed as more than one biological entity. We studied the factors
potentially contributing to this phenomenon, specifically ...

BACKGROUND: Adenocarcinomas (ACs) and squamous cell carcinomas (SCCs) differ by clinical
and molecular characteristics. We evaluated the characteristics of carcinogenesis
by modeling the age patterns of incidence rates of ...

BACKGROUND: Current guidelines define severe aortic valve stenosis (AS) as an aortic
valve area (AVA) ≤1.0 cm by the continuity equation and mean gradient (ΔPm) ≥ 40 mm
Hg. However, these measurements can be discordant when ...

Multi-morbidity is common among older adults; however, for many aging-related diseases
there is no information for U.S. elderly population on how earlier-manifested disease
affects the risk of another disease manifested ...

BACKGROUND: The respiratory tract is a major target of exposure to air pollutants,
and respiratory diseases are associated with both short- and long-term exposures.
We hypothesized that improved air quality in North Carolina ...