The rest of this article is devoted solely to mucus production and function in humans.

Contents

Respiratory system1

Diseases involving mucus1.1

Cystic fibrosis1.1.1

Mucus as a medical symptom1.1.2

Cold weather and nasal mucus1.2

Digestive system2

Reproductive system3

See also4

Notes5

References6

Respiratory system

Illustration depicting the movement of mucus in the respiratory tract.

In the human respiratory system, mucus aids in the protection of the lungs by trapping foreign particles that enter it, in particular, through the nose, during normal breathing. "Phlegm" is a specialized term for mucus that is restricted to the respiratory tract, whereas the term "nasal mucus" describes secretions of the nasal passages.

Nasal mucus is produced by the nasal mucosa; and mucosal tissues lining the airways (trachea, bronchus, bronchioles) is produced by specialized airway epithelial cells (goblet cells) and submucosal glands. Small particles such as dust, particulate pollutants, and allergens, as well as infectious agentsbacteria are caught in the viscous nasal or airway mucus and prevented from entering the system. This event along with the continual movement of the respiratory mucus layer toward the oropharynx, helps prevent foreign objects from entering the lungs during breathing. This explains why coughing often occurs in those who smoke filtered cigarettes. The body's natural reaction is to increase mucus production. In addition, mucus aids in moisturizing the inhaled air and prevents tissues such as the nasal and airway epithelia from drying out.[3] Nasal and airway mucus is produced continuously, with most of it swallowed unconsciously, even when it is dried.[4]

Increased mucus production in the respiratory tract is a symptom of many common illnesses, such as the common cold and influenza. Hypersecretion of mucus can occur in inflammatory respiratory diseases such as respiratory allergies, asthma, and chronic bronchitis.[3] The presence of mucus in the nose and throat is normal, but increased quantities can impede comfortable breathing and must be cleared by blowing the nose or expectoratingphlegm from the throat.

Diseases involving mucus

In general, nasal mucus is clear and thin, serving to filter air during inhalation. During times of infection, mucus can change color to yellow or green either as a result of trapped bacteria[5] or due to the body's reaction to viral infection.[6] The green color of mucus comes from the heme group in the iron-containing enzyme myeloperoxidase secreted by white blood cells as a cytotoxic defense during a respiratory burst.

In the case of bacterial infection, the bacterium becomes trapped in already-clogged sinuses, breeding in the moist, nutrient-rich environment. Sinusitis is an uncomfortable condition which may include congestion of mucus. A bacterial infection in sinusitis will cause discolored mucus and would respond to antibiotic treatment; viral infections typically resolve without treatment.[7] Almost all sinusitis infections are viral and antibiotics are ineffective and not recommended for treating typical cases.[8]

In the case of a viral infection such as cold or flu, the first stage and also the last stage of the infection cause the production of a clear, thin mucus in the nose or back of the throat. As the body begins to react to the virus (generally one to three days), mucus thickens and may turn yellow or green. Viral infections cannot be treated with antibiotics, and are a major avenue for their misuse. Treatment is generally symptom-based; often it is sufficient to allow the immune system to fight off the virus over time.[9]

Cystic fibrosis

Cystic fibrosis is an inherited disease that affects the entire body. Symptoms begin mostly in the lungs, with viscous (thick) mucus that is difficult to expel.

Mucus as a medical symptom

Increased mucus production in the upper respiratory tract is a symptom of many common ailments, such as the histamines,[10] may be treated cautiously with decongestant medications. Excess mucus production in the bronchi and bronchioles, as may occur in asthma, bronchitis or influenza, may be treated with anti-inflammatory medications as a means of reducing the airway inflammation, which triggers mucus over-production. Thickening of mucus as a "rebound" effect following overuse of decongestants may produce nasal or sinus drainage problems and circumstances that promote infection.

Cold weather and nasal mucus

During exposure to cold weather, the cilia, which normally sweep mucus away from the nostrils and toward the back of the throat (see respiratory epithelium), become sluggish or completely cease functioning. This results in mucus running down the nose and dripping (a runny nose). Mucus also thickens in cold weather; when an individual comes in from the cold, the mucus thaws and begins to run before the cilia begin to work again.

Digestive system

In the human digestive system, mucus is used as a lubricant for materials that must pass over membranes, e.g., food passing down the

In the human female reproductive system, cervical mucus prevents infection. The consistency of cervical mucus varies depending on the stage of a woman's menstrual cycle. At ovulation cervical mucus is clear, runny, and conducive to sperm; post-ovulation, mucus becomes thicker and is more likely to block sperm.[11] Several Fertility Awareness methods, such as the Creighton Model and Billings method rely on this fact to prevent or to improve the odds of pregnancy.

Reproductive system

Mucus is not digested in the intestinal tract. Mucus is also secreted from glands within the rectum due to stimulation of the mucous membrane within.
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