CIOMS/RUCAM Scale

Roussel Uclaf Causality Assessment Method

"Causality assessment of adverse reactions to drugs I.
A novel method based on the conclusions of international consensus meetings: application to drug-induced liver injuries. "

J. Clin. Epidemiol. (1993) 46 1323-1330.

I➜The Council for International Organizations of Medical Sciences/Roussel Uclaf Causality Assessment Method (abbreviated CIOMS/RUCAM) scale, has been proposed to establish causal relationship between offending drug and liver damage.
This complex algorithm is currently the standard instrument for causality assessment of hepatotoxicity and has been shown to be more reliable and reproducible than other scales in the evaluation of drug-induced liver injury (DILI) . Cutt-off points and categories are: “definite or highly probable” (score > 8), “probable” (score 6-8), “possible” (score 3-5), “unlikely” (score 1-2) and “excluded” (score ≤ 0).