Some people go off gluten because they have gastrointestinal problems. Others because they think it will aid with weight loss. Yet others are convinced that a gluten-free diet is more healthful. By one estimate, almost 1 American in 3 reports cutting down on gluten, a mixture of proteins that is found in grains such as wheat, barley and rye. Yet scientists warn that, for most people, this may be a bad idea.

For those with celiac disease, eating the wrong foods can be life-threatening. But there's no such danger for people with another condition -- non-celiac gluten sensitivity (NCGS) -- that has recently gained traction as a reason for going gluten-free.

"Although non-celiac gluten sensitivity appears to be a real problem, a substantial number of people are on a too-restricted diet," says Knut Lundin, a Norwegian gastroenterologist who researches both celiac disease and NCGS.

If it's not a medical necessity, doctors say, going gluten-free could mean a diet that's lacking in important nutrients, damaging to your gut flora and -- ironically, for those trying to slim down -- making you fat.

A MYSTERIOUS AILMENT

Although NCGS has been known in scientific circles since 1970s, researchers can't agree on what it really is. So far, the most common way of defining the condition is saying what it isn't: not celiac disease, not an allergy.

Celiac disease is an autoimmune disorder in which gluten ingestion damages the small intestine, leading to problems with nutrient absorption and sometimes to Type 1 diabetes, multiple sclerosis, infertility, malnutrition, cancer and even early death.

About 1 percent of Americans have celiac disease. It can be diagnosed by a blood test followed by a biopsy of the small intestine to look for inflammation.

Wheat allergy, on the other hand, is an immunologic reaction to wheat proteins, including gluten, that affects only about 1 Westerner in 1,000 -- though it, too, may kill.

For NCGS, however, there are no tests. If a person complains of certain symptoms -- abdominal pain, nausea, bloating, diarrhea or constipation, headaches -- the only way of knowing whether gluten is the problem is through a gluten challenge.

According to Umberto Volta, a professor of medicine at Italy's University of Bologna and one of the leading researchers in NCGS, in an ideal world each person suspected of gluten sensitivity would go through a double-blind, placebo-controlled trial. After a few weeks on a gluten-free diet, the person would try different doctor-prescribed products, not knowing whether they contain gluten, and any resulting symptoms would be noted.

"Unfortunately, this procedure is time-consuming and difficult to perform routinely, so it's still confined to the clinical setting," Volta says. Since gluten-free and gluten-containing versions of available food products vary in taste, tests are hard to do. This can lead to a "nocebo effect": If the patient believes he is getting gluten, he may feel worse even if his food is gluten-free. "A thorough assessment of such patients often reveals that other factors, such as small intestinal bacterial overgrowth or lactose intolerance, are responsible for their symptoms," Volta says.

COMMON -- OR NOT

The lack of diagnostic tools and the nocebo effect make it difficult to know how many people have NCGS. Estimates vary widely, ranging from 0.5 percent (an American study) to 6 percent (a British study).

To add to the confusion, lab experiments involving NCGS differ in their outcomes. In 2011, a double-blind, placebo-controlled trial on patients with irritable bowel syndrome, whose symptoms include bloating, diarrhea and nausea, found that they fared worse after consuming gluten. But that study allowed patients to stay on their usual diets, possibly confounding the findings. Yet a few studies do point to gluten as the likely reason why some people feel bad after eating wheat-based bread or cookies.

"In the United States, 83 percent of people who have celiac disease don't know about it. That is why absolutely no one should be going on a gluten-free diet before they have been tested for celiac," says Tricia Thompson, a registered dietitian who specializes in gluten-free diets.

If you do have celiac disease, cutting down on gluten can make you feel better -- good enough not to seek medical advice -- yet even minimal amounts of gluten will continue damaging your small intestine, raising the risk of complications.

DON'T SELF-PRESCRIBE

A self-prescribed gluten-free diet can mess up celiac diagnosis. "If you have celiac and you start a gluten-free diet, your gut will normalize and your blood results will normalize, which makes diagnosis difficult," Lundin says.

Meanwhile, for those who don't have celiac or NCGS, loading up on gluten may be a good idea.

For one, gluten -- specifically, the amino acid glutamine, which is found in gluten -- may boost the immune system.

Second, a diet high in gluten may be good for your heart. In one Canadian study, when adults with elevated LDL cholesterol -- often called "bad" cholesterol -- increased their consumption of gluten, their serum triglyceride levels (which when elevated suggest cardiovascular health risk) went down by 13 percent within two weeks.

And third, beneficial gut bacteria thrive on gluten. These are the types of bacteria that help with digestion, boost the immune system and keep people lean.Although it is possible to compose a gluten-free diet that contains all necessary nutrients, doing so is not easy, "Gluten-free diets as typically followed in the United States tend to be low in calcium, iron, folate, B3, B12, phosphorus and zinc," says Thompson, who 15 years ago was among the first to point out the nutritional pitfalls of going gluten-free.

Can a gluten-free diet at least help you lose weight? More likely just the opposite, experts say. "Frequently patients risk weight gain due to higher caloric content of gluten-free products," says Volta.

To make gluten-free products appealing, extra fat and starches are often added, which means more calories.