American Lung Association Study Finds No Evidence of Depression or Suicide Linked to Asthma and Allergy Drug Montelukast

... WASHINGTON Sept. 1 -- There has been rece...American Lung Association researchers Janet Holbrook PhD MPH andRai... Discovering adverse effects of a drug after it is on the market can b...Holbrook and Harik-Khan reviewed quality of life and emotional wellbe...

WASHINGTON, Sept. 1 /PRNewswire-USNewswire/ -- There has been recent
concern that suicide may be a complication of montelukast (Singulair)
therapy. Montelukast is a Food and Drug Administration (FDA) approved oral
drug that has been prescribed for more than a decade for the treatment of
asthma and seasonal allergy symptoms. An independent study sponsored by the
American Lung Association has found no evidence of depression or suicide
linked to montelukast.

American Lung Association researchers Janet Holbrook, PhD, MPH and
Raida Harik-Khan, PhD have re-analyzed data from patients who had
participated in past clinical trials involving montelukast conducted by the
Association's Asthma Clinical Research Centers (ACRC) Network to identify
any signals that might suggest a link between montelukast and its effect on
emotional well- being. They report their findings in an upcoming issue of
the Journal of Allergy and Clinical Immunology.

"Discovering adverse effects of a drug after it is on the market can be
very difficult, because the data are usually gathered from single events
reported by doctors, which makes it is challenging to differentiate actual
side effects from events unrelated to the drug," said Norman Edelman, MD
American Lung Association Chief Medical Officer. "The value of this 'look
back' study is that the investigators were able to compare a large group of
patients given montelukast with those given a placebo making a firm
scientific conclusion possible."

Holbrook and Harik-Khan reviewed quality of life and emotional well
being data collected from patients in three American Lung Association ACRC
Network clinical trials that had used montelukast as one of their
treatments. Of the 1,352 patients who participated in the double-blind,
controlled studies, 569 of these patients had been randomly assigned to
take montelukast. The researchers analyzed these patients' data and found
no evidence of any deterioration of emotional well being in '/>"/>

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