This recombinant protein was expressed from a DNA sequence encoding the extracellular domain (Met 1-Arg 152) of human ALK3 (NP_004320.2) fused to the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus

Specifications

Bone Morphogenetic Protein Receptor, Type IA (BMPR1A), recombinant human protein is supplied as a lyophilized powder. It is suitable for use in analysis of protein structure, and performing cell based assays. It can also be used as an immunogen, as a protein standard, or in other research applications. Since this product is a truncated protein and does not contain intracellular catalytic activity domain, it is not suitable for use in enzyme activity studies.

Activity: Measured by its ability to inhibit BMP4 induced activity in MC3T3-E1 Mouse osteoblastic cells, the ED50 for this effect is typically 0.1-0.3μg/mL in the presence of 50ng/mL of recombinant human BMP4