Translation of the abstract (English)

Active immunization as prophylaxis against Hepatitis-B-virus induces an adaptive immune response and HBsAg-specific CD4+T-cells. Aim of this thesis was the functional characterization of vaccine-induced HBsAg-specific CD4+T-cells and the investigation of their role in the control of the HBV-infection of human hepatocytes. In coculture experiments with HBV-infected human hepatocytes HBV-specific ...

Translation of the abstract (English)

Active immunization as prophylaxis against Hepatitis-B-virus induces an adaptive immune response and HBsAg-specific CD4+T-cells. Aim of this thesis was the functional characterization of vaccine-induced HBsAg-specific CD4+T-cells and the investigation of their role in the control of the HBV-infection of human hepatocytes. In coculture experiments with HBV-infected human hepatocytes HBV-specific PBMC induced a significant reduction of viral transcription, viral replication and antigen production. The antiviral effect of the PBMC from different donors was reversibel and in strong correlation to their specific T-cell-reactivity. The results of these studies give clear evidence, that vaccine-induced HBsAg-specific CD4+T-cells have antiviral effector function on the HBV-infection of human hepatocytes.