(Sunday, 4:25 p.m. ET, CBS)Tom Brady and Peyton Manning both have plenty of playmakers in their supporting cast to make this a wire-to-wire, back-and-forth scoring game. The difference will be the Patriots are more capable of confusing the Broncos with versatility in play-calling and personnel. Patriots 38, Broncos 34.

It's No. 7 vs. No. 7 as keys to the Keystone State battle. Michael Vick and Ben Roethlisberger will both work to use their mobility to avoid the pass rush and hit on long passes. Big Ben will be more efficient at home, and the bye will also help Dick LeBeau's defense come up with the right wrinkles to rattle Vick. The Steelers' wideouts will win their marquee matchup with the Eagles' corners. Steelers 23, Eagles 20.

It's a bittersweet game for Drew Brees. He will break Johnny Unitas' record for consecutive games with a touchdown pass at 48 and do it against the team that drafted him. He also should prevail at home against the quarterback, Philip Rivers, who replaced him. Despite making history, the Saints' resulting 1-4 record will eat at Brees as a competitor. Saints 34, Chargers 30

Following a successful leisure trip to Cowboys Stadium, Bears fans will take over the EverBank, banking on their team to drag the Jags through another offensive struggle. Julius Peppers will lead the way in pressuring Blaine Gabbert into mistakes. Chicago will then run away with Matt Forte and Michael Bush in a second-half power rushing attack. Bears 30, Jaguars 10

It's the NFC offensive player of the month, Matt Ryan, against the offensive rookie of the month, Robert Griffin III. There should be some passing fireworks from both quarterbacks, but Griffin faces the tougher secondary and overall defense. Look for a healthy Julio Jones to burn Washington for big plays down the middle. Falcons 34, Redskins 27

The Chiefs have lost their Arrowhead Stadium mojo, and the Ravens won't allow them to rediscover it. Coming off extra rest, look for Baltimore to put the game away early with scoring plays and have its defense tee off on Matt Cassel. Also expect a huge day from scrimmage for Ray Rice. Ravens 34, Chiefs 17

The Giants will be without their top wide receiver, Hakeem Nicks, but the Browns are still missing their top cornerback, Joe Haden. That should make the Eli Manning-Victor Cruz combination sizzle, with at least one end-zone salsa. As Brandon Weeden and the Browns play catch-up, fellow rookie Trent Richardson will remain the bright spot. Giants 30, Browns 20

The Colts will be inspired post-bye to play hard for sidelined coach Chuck Pagano, and rookie Andrew Luck will be pumped to show he can be the next Aaron Rodgers. It won't be quite a Indy shootout like Manning vs. Brett Favre was eight years ago, however. Rodgers has more reliable weapons than Luck, even minus Greg Jennings.
Packers 35, Colts 21

There's no reason to think Bengals wide receiver A.J. Green will slow down against the Dolphins' secondary. If they focus on him, Andy Dalton has proved he doesn't mind spreading the ball around downfield. The Bengals, who lead the league in sacks (16), will then make sure Ryan Tannehill can't stay with Dalton. Bengals 23, Dolphins 16

Russell Wilson is an athletic passer, but he's not as big, strong or skilled as Cam Newton. Russell also lacks Newton's receiving options. That will give the Panthers' reeling secondary a break. The Seahawks have a strong, physical back seven, but the Panthers will find a way to slip Steve Smith and Greg Olsen past them at critical times. Panthers 20, Seahawks 16

The Niners thrive on turnovers, and the Bills' offense, led by Ryan Fitzpatrick, has been very accommodating in that area. There will be heat on Fitzpatrick as Buffalo's banged-up backfield is a non-factor. After holding back Alex Smith last week, here's a chance for San Francisco to let him loose with his wideouts again. 49ers 38, Bills 14

The Jets couldn't get shut out at home in consecutive weeks, could they? And in prime time, no less? Yes, they can. The Texans' 3-4 defense will build on the Niners' momentum, and force sputtering New York into the inevitable: Playing Tim Tebow in uninspiring mop-up duty to set up an upcoming start. Texans 38, Jets 0