Adrenal Fatigue supplements... I need a list

So your telling me that the adrenals are the only organ that can't be over worked?

again, look at a patient with cushings. Their adrenals receive a constant stimulus and kick out cortisol almost non stop, and they never once get "fatigued" so how is this idea that they are able to become tired?

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Can a simple question be asked that would allow a fairly straight forward answer,
What causes/can cause adrenal insufficiency?
Use of stims then stopping them, ongoing stress, poor sleep, sh***y diet and lifestyle, or is the cause not that easy?

What you'll come to learn is that there are basically a ton of things that can cause this.

Like Josh mentioned with Cushing's, you could have an adenoma that causes all of this. All it takes is one thing getting screwed up in the body to make a bunch of other things messed up, as well.

Psalm 34:10 - "The lions may grow weak and hungry, but those who seek the Lord lack no good thing."EvoMuse Representative |[email protected] | Inspire to Evolve

02-29-2012, 02:31 PM

sizematters10

Originally Posted by JudoJosh

here is where the problem begins. It is the idea that your adrenals have the ability to get tired, fatigued or overworked. This is simply not true and there is absolutely nothing to suggest that it is even a possibility.

Think about a patient who has cushing. Their adrenals will kick out enormous amounts of cortisol almost non stop and not once do they "get tired". So let me the ask, if someones adrenals with cushings, which is reciving a constant stimulus, and their adrenals continue to function just fine, what makes you think it is possible for our adrenals to get fatigued?

Adrenal fatigue is more then just a mislabel because along with this term comes the idea that if you give them a "rest" somehow everything will get better. Now is it possible for someone to have a adrenal insufficiency? Absolutely and it is called addisons disease but more than likely when someone uses the horrible term "adrenal fatigue" they are usually describing HPA dysfunction. When this happens, yes the body can stop naturally producing enough hormones BUT it isnt because the adrenals are tired but usually a deeper underlying cause which is causing something to become out of balance and if I remember correctly the typical treatment given for this is glucocorticoids but even then it has had a fairly limited success rate. As coop said this is relatively new and there are still many unanswered questions.

Think of it this way (is steroid terms )
I am going to try and compare the HPA axis to the HPTA

Here we have you HPA axis

Now my understanding of it is the hypothalamus will sense serum cortisol and modulate CRH/ACTH output in so to keep glucocortcoid levels constant.

Now to compare this to the HPTA

the way this works is somewhat similar, the hypothalamus releases GnHR and GHRH to our pituitary which in turn releases LH and FSH to the testes which release the testosterone.

Now with HPA dysfunction, it is not that the adrenals become "fatigued" but it is that a mechanism exists by which adrenal response is chronically down-regulated (usually after a prolonged period of stress) and this mechanism as far as I know has yet to be identified (although there are some theories floating about).

Now back to the HPTA comparison, with HPA dysfunction basically something is out of wack and you end up with a low hypothalamic CRH production which leads to low cortisol production. Now lets compare to someone whose HPTA is out of wack shall we. We all know that when coming off a cycle of exogenous androgens our body down regulates testosterone production (via negative feedback of the androgens). What we end up with is too many androgen receptors of the hypothalamus have become activated so there is a decrease in GnRH release which ultimately equals a decrease in testosterone production.

Now that said, does anything in the HPTA become "fatigued"? Or is it there was a disruption of the balance (i.e the introduction of exogenous androgens)? Would the solution to low test be to give your testes or leydig cells a rest? No it wont be, the solution is to somehow stimulate GnHR release. So if the solution to low test output isnt rest then why is the solution to low adrenal output that it needs rest?

The main problem with HPA dysfunction is we dont know exactly what the mechanism for adrenal fatigue is. Again, as Coop said above , the developments in the understanding in all of this is fairly recent and there is much that is still unknown. Oh and Mr coop if I got anything wrong please feel free to correct me as I dont have a full grasp of it entirely yet.

still seems like semantics in your last point with HPTA (exogeneous hormones --->low test output), the consequent brought about by a causal influence may not be straightforward "fatigue" but nonetheless is brought about by the presence of stimulants (hypothetically speaking of course-if there was a correlation stimulant ---> (effect of non-optimally performing adrenals or dysfunction)

if there was a correlation, it may be like in the case of steroids where a mere pause isn't sufficient, but adding in auxillary compound will provide pct, or it may be refraining altogether (this is all hypothetical-haven't read studies or familiar with the work)

idk though-interesting stuff- haven't read the studies and all of that

I am stim free other than coffee in the morning. I am working 14-16 hour days, plus added life stressors. I am tired, lack of motovation, irritable. I was thinking maybe and anti-cortisol supplement. I am not going prescription drug route.

I am stim free other than coffee in the morning. I am working 14-16 hour days, plus added life stressors. I am tired, lack of motovation, irritable. I was thinking maybe and anti-cortisol supplement. I am not going prescription drug route.

Have you had any tests done?

In all honesty, those side effects could accompany a large number of things, so it could be more than an adrenal issue (could be low test, decreased dopamine or serotonin, etc.).

Psalm 34:10 - "The lions may grow weak and hungry, but those who seek the Lord lack no good thing."EvoMuse Representative |[email protected] | Inspire to Evolve

No tests. Didn't think it was that complicated. Just run down a little.

When it comes to the level of how complicated: it is and it isn't. lol

Chances are, it's what you think it is. From the sound of your work schedule, it sounds like you could benefit from some extra sleep and relaxation time. I only bring this up, because those symptoms are so common among a plethora of things.

And Josh brings up a good point on the adpatagens.

Psalm 34:10 - "The lions may grow weak and hungry, but those who seek the Lord lack no good thing."EvoMuse Representative |[email protected] | Inspire to Evolve