‘SPIN City” Mayor Randall Winston will contemplate a run for the U.S. Senate against a tough-as-nails female opponent.

Sound familiar? That’s because ABC’s Gotham-based “Spin City” is having fun with New York’s biggest political story in years – the anticipated Senate dustup between Mayor Giuliani and First Lady Hillary Clinton.

“I think it’s very much like what Giuliani is doing,” said “Spin City” executive producer David Rosenthal. “Everyone knows [Giuliani] is running – although he hasn’t officially declared anything yet.

“There will be a very strong female opponent,” Rosenthal said. “It won’t be the First Lady, but we’ll probably get a great female actress to run against Winston as his rival.”

Winston’s announcement will also set the stage for the show’s newest character – his campaign manager Caitlin Moore, played by ex-“Melrose Place” vixen Heather Locklear.

Moore will lock horns with Deputy Mayor Michael Flaherty (Michael J. Fox) as a rival for Winston’s attention – and as a possible romantic interest for Flaherty.

The slightly dim Winston, played by Barry Bostwick, will announce his intentions to run for Senate on the show’s fourth-season opener, airing Tuesday, Sept. 21 (8 p.m. on Ch.7).

“We’ll try to follow the upcoming political season as closely as possible,” Rosenthal said. “The primaries will fall at the end of our season, and we’ll carry [Winston’s] campaign through to the end.

“I think this is definitely a reflection of the times,” Rosenthal said. “What’s great about our show is that we shoot in the city and we read the papers everyday.

“There’s so much stuff going in City Hall and around the city that it serves as a great inspiration,” he said. “We’re always looking in the mirror and commenting on what’s going on.”