From 1882 to 1963, Perkinsville was on the New York (Hoboken) to Buffalo Main Line of the Delaware, Lackawanna & Western Railroad (1882-1960) and Erie Lackawanna Railroad (1960-1963). Tracks were removed through Perkinsville in 1963 by order of the United States Interstate Commerce Commission to promote highway transportation. As of 2008, Perkinsville has no rail service.