(Medical Xpress)—Meet the hippocampus: A seahorse-shaped structure in the cerebral cortex's medial temporal lobe, it's part of the limbic system, generally believed to be involved in spatial navigation and establishing ...

Loss of memory is a well-established symptom of Alzheimer's disease. Also, cognitive impairment and personality changes are also observed in these patients. Many studies investigating the causes of Alzheimer's have focused ...

The hippocampus in the brain's temporal lobe is responsible for more than just long-term memory. Researchers have for the first time demonstrated that it is also involved in quick and successful conflict resolution. The team ...

(Medical Xpress)—Human memory is remarkably adaptive and specific, enabling the crucial distinction between two similar events—for instance, recalling where you parked your car this morning as opposed to where you parked ...

Researchers at McGill have clearly identified, for the first time, the specific parts of the brain involved in decisions that call for delayed gratification. In a paper recently published in the European Journal of Neuroscience, ...

Are the same regions and even the same cells of the brain area called hippocampus involved in encoding and retrieving memories or are different areas of this structure engaged? This question has kept neuroscientists busy ...

When remembering something from our past, we often vividly re-experience the whole episode in which it occurred. New UCL research funded by the Medical Research Council and Wellcome Trust has now revealed how this might happen ...

The brain region that helps people tell whether an object is near or far may also guide how emotionally close they feel to others and how they rank them socially, according to a study conducted at the Icahn School of Medicine ...

Hippocampus

The hippocampus is a major component of the brains of humans and other mammals. It belongs to the limbic system and plays important roles in long-term memory and spatial navigation. Like the cerebral cortex, with which it is closely associated, it is a paired structure, with mirror-image halves in the left and right sides of the brain. In humans and other primates, the hippocampus is located inside the medial temporal lobe, beneath the cortical surface. Its curved shape reminded early anatomists of the horns of a ram (Cornu Ammonis), or a seahorse. The name, in fact, was taken by the sixteenth century anatomist Julius Caesar Aranzi from the Greek word for seahorse (Greek: ιππος, hippos = horse, καμπος, kampos = sea monster).

In Alzheimer's disease the hippocampus is one of the first regions of the brain to suffer damage; memory problems and disorientation appear among the first symptoms. Damage to the hippocampus can also result from oxygen starvation (hypoxia), encephalitis, or medial temporal lobe epilepsy. People with extensive hippocampal damage may experience amnesia—the inability to form or retain new memories.

In rodents, the hippocampus has been studied extensively as part of the brain system responsible for spatial memory and navigation. Many neurons in the rat and mouse hippocampus respond as place cells: that is, they fire bursts of action potentials when the animal passes through a specific part of its environment. Hippocampal place cells interact extensively with head direction cells, whose activity acts as an inertial compass, and with grid cells in the neighboring entorhinal cortex.

Because of its densely packed layers of neurons, the hippocampus has frequently been used as a model system for studying neurophysiology. The form of neural plasticity known as long-term potentiation (LTP) was first discovered to occur in the hippocampus and has often been studied in this structure. LTP is widely believed to be one of the main neural mechanisms by which memory is stored in the brain.