A group of Manhattan Project physicists created a tongue-in-cheek mythology where superintelligent Martian scouts landed in Budapest in the late 19th century and stayed for about a generation, after which they decided the planet was unsuitable for their needs and disappeared. The only clue to their existence were the children they had with local women.

The joke was that this explained why the Manhattan Project was led by a group of Hungarian supergeniuses, all born in Budapest between 1890 and 1920. These included Manhattan Project founder Leo Szilard, H-bomb creator Edward Teller, Nobel-Prize-winning quantum physicist Eugene Wigner, and legendary polymath John von Neumann, namesake of the List Of Things Named After John Von Neumann.

The coincidences actually pile up beyond this. Von Neumann, Wigner, and possibly Teller all went to the same central Budapest high school at about the same time, leading a friend to joke about the atomic bomb being basically a Hungarian high school science fair project. ...

... Laszlo Polgar studied intelligence in university, and decided he had discovered the basic principles behind raising any child to be a genius. He wrote a book called Bring Up Genius and recruited an interested woman to marry him so they could test his philosophy by raising children together. He said a bunch of stuff on how ‘natural talent’ was meaningless and so any child could become a prodigy with the right upbringing.

This is normally the point where I’d start making fun of him. Except that when he trained his three daughters in chess, they became the 1st, 2nd, and 6th best female chess players in the world, gaining honors like “youngest grandmaster ever” and “greatest female chess player of all time”. Also they spoke seven languages, including Esperanto.

Their immense success suggests that education can have a major effect even on such traditional genius-requiring domains as chess ability. How can we reconcile that with the rest of our picture of the world, and how obsessed should we be with getting a copy of Laszlo Polgar’s book? ...

Friday, May 26, 2017

This blog gets about 100k page views per month. My sense is that there are a lot of additional views through RSS feeds and social media (FB, G+, etc.), but those are hard to track. Most of the hits are on the main landing page, with a smaller fraction going to a specific article. I'd guess that someone hitting the landing page looks at a few posts, so there are probably at least 200k article views per month. I write somewhat fewer than 20 posts per month, which suggests that a typical post is read ~10k times. Some outlier posts get a lot of traffic from inbound links and search engine results even years after they were written. These have far more than 10k cumulative views, according to logs. From cookies, I can see that there are many thousands of regular readers (i.e., who visit at least several times a month).

Is there any better way to estimate impact/reach than what I've described above?

For comparison, I was told that a serious non-fiction book on the NY Times Best Seller list might sell ~10k copies. So it seems possible my blog has a significantly greater reach than what I could expect from writing a book. I've thought about writing books at various times, but have always been too busy. I fantasize about writing more when I retire, or later in my career :-)

When I attend meetings or conferences, I often bump into people I don't know who tell me they read my blog. This seems to be true whether the participants are scientists, technologists, investors, or academics. I'm guessing that for every person who tells me that they're a reader, there must be many more who are readers but don't volunteer the information. If you ever see me in person, please come right up and say hello! :-)

I've been told by some people that they have tried to read this blog but find it hard to understand. I suppose that regular readers are mostly well above average in intelligence.
Borges once said

... the life of a writer is a lonely one. You think you are alone, and as the years go by, if the stars are on your side, you may discover that you are at the center of a vast circle of invisible friends whom you will never get to know, but who love you. And that is an immense reward.

Thursday, May 25, 2017

... Immediately after the White House directive the Theoretical Division at Los Alamos had started calculations for the new bomb.

... There was a meeting in Teller's office with Fermi, von Neumann, and Feynman ... Many ideas were thrown back and forth and every few minutes Fermi or Teller would devise a quick numerical check and then they would spring into action. Feynman on the desk calculator, Fermi with the little slide rule he always had with him, and von Neumann, in his head. The head was usually first, and it is remarkable how close the three answers always checked.

The MANIAC:

... When von Neumann released his last invention for use, it aroused the admiration of all who worked with it. Carson Mark, head of the Theoretical Division at Los Alamos, recollects that 'a problem which would have otherwise kept three people busy for three months; could be solved by the aid of this computer, worked by the same three people, in about ten hours. The physicist who had set the task, instead of having to wait for a quarter of a year before he could get on, received the data he required for his further work the same evening. A whole series of such three months' calculations, narrowed down to a single working day, were needed for the production of the hydrogen bomb.

It was a calculating machine, therefore, which was the real hero of the work on the construction of the bomb. It had a name of its own, like all the other electronic brains. Von Neumann had always been fond of puns and practical jokes. When he introduced his machine to the Atomic Energy Commission under the high-sounding name of 'Mathematical Analyser, Numerical Integrator and Computer', no one noticed anything odd about this designation except that it was rather too ceremonious for everyday use. It was not until the initial letters of the six words were run together that those who used the miraculous new machine realized that the abbreviation spelled 'maniac'.

Wednesday, May 24, 2017

Humans are going to have to learn to "trust the AI" without understanding why it is right. I often make an analogous point to my kids -- "At your age, if you and Dad disagree, chances are that Dad is right" :-) Of course, I always try to explain the logic behind my thinking, but in the case of some complex machine optimizations (e.g., Go strategy), humans may not be able to understand even the detailed explanations.

In some areas of complex systems -- neuroscience, genomics, molecular dynamics -- we also see machine prediction that is superior to other methods, but difficult even for scientists to understand. When hundreds or thousands of genes combine to control many dozens of molecular pathways, what kind of explanation can one offer for why a particular setting of the controls (DNA pattern) works better than another?

There was never any chance that the functioning of a human brain, the most complex known object in the universe, could be captured in verbal explication of the familiar kind (non-mathematical, non-algorithmic). The researchers that built AlphaGo would be at a loss to explain exactly what is going on inside its neural net...

NYTimes: ... “Last year, it was still quite humanlike when it played,” Mr. Ke said after the game. “But this year, it became like a god of Go.”

... After he finishes this week’s match, he said, he would focus more on playing against human opponents, noting that the gap between humans and computers was becoming too great. He would treat the software more as a teacher, he said, to get inspiration and new ideas about moves.

“AlphaGo is improving too fast,” he said in a news conference after the game. “AlphaGo is like a different player this year compared to last year.”

“After humanity spent thousands of years improving our tactics, computers tell us that humans are completely wrong,” Mr. Ke, 19, wrote on Chinese social media platform Weibo after his defeat. “I would go as far as to say not a single human has touched the edge of the truth of Go.”

The results are not especially surprising to people who have been following the subject, but this is the largest sample of genomes and cognitive scores yet analyzed (~80k individuals). SSGAC has assembled a much larger dataset (~750k, soon to be over 1M; over 600 genome-wide significant SNP hits), but are working with a proxy phenotype for cognitive ability: years of education.

Intelligence is associated with important economic and health-related life outcomes1. Despite intelligence having substantial heritability2 (0.54) and a confirmed polygenic nature, initial genetic studies were mostly underpowered3, 4, 5. Here we report a meta-analysis for intelligence of 78,308 individuals. We identify 336 associated SNPs (METAL P < 5 × 10−8) in 18 genomic loci, of which 15 are new. Around half of the SNPs are located inside a gene, implicating 22 genes, of which 11 are new findings. Gene-based analyses identified an additional 30 genes (MAGMA P < 2.73 × 10−6), of which all but one had not been implicated previously. We show that the identified genes are predominantly expressed in brain tissue, and pathway analysis indicates the involvement of genes regulating cell development (MAGMA competitive P = 3.5 × 10−6). Despite the well-known difference in twin-based heratiblity2 for intelligence in childhood (0.45) and adulthood (0.80), we show substantial genetic correlation (rg = 0.89, LD score regression P = 5.4 × 10−29). These findings provide new insight into the genetic architecture of intelligence.

Perhaps the most interesting aspect of this study is the further evidence it provides that many (the vast majority?) of the hits discovered by SSGAC are indeed correlated with cognitive ability (as opposed to other traits such as Conscientiousness, which might influence educational attainment without affecting intelligence):

To examine the robustness of the 336 SNPs and 47 genes that reached genome-wide significance in the primary analyses, we sought replication. Because there are no reasonably large GWAS for intelligence available and given the high genetic correlation with educational attainment, which has been used previously as a proxy for intelligence7, we used the summary statistics from the latest GWAS for educational attainment21 for proxy-replication (Online Methods). We first deleted overlapping samples, resulting in a sample of 196,931 individuals for educational attainment. Of the 336 top SNPs for intelligence, 306 were available for look-up in educational attainment, including 16 of the independent lead SNPs. We found that the effects of 305 of the 306 available SNPs in educational attainment were sign concordant between educational attainment and intelligence, as were the effects of all 16 independent lead SNPs (exact binomial P < 10−16; Supplementary Table 14). ...

Carl Zimmer did a good job with the Times story. The basic ideas, that

0. Intelligence is (at least crudely) measurable
1. Intelligence is highly heritable (much of the variance is determined by DNA)
2. Intelligence is highly polygenic (controlled by many genetic variants, each of small effect)
3. Intelligence is going to be deciphered at the molecular level, in the near future, by genomic studies with very large sample size

are now supported by overwhelming scientific evidence. Nevertheless, they are and have been heavily contested by anti-Science ideologues.

Sunday, May 21, 2017

How Alexander Sachs, acting on behalf of Szilard and Einstein, narrowly convinced FDR to initiate the atomic bomb project. History sometimes hangs on a fragile thread: had the project been delayed a year, atomic weapons might not have been used in WWII. Had the project completed a year earlier, the bombs might have been used against Germany.

... This international financier could always obtain entry to the White House, for he had often amazed Roosevelt by his usually astonishingly accurate forecasts of economic events. Ever since 1933 Sachs had been one of the unofficial but extremely influential advisers of the American President, all of whom had to possess, by F. D. R.'s own definition, 'great ability, physical vitality, and a real passion for anonymity'.

... It was nearly ten weeks before Alexander Sachs at last found an opportunity, on October 11, 1939, to hand President Roosevelt, in person, the letter composed by [Leo] Szilard and signed by [Albert] Einstein at the beginning of August [1939]. In order to ensure that the President should thoroughly appreciate the contents of the document and not lay it aside with a heap of other papers awaiting attention, Sachs read to him, in addition to the message and an appended memorandum by Szilard, a further much more comprehensive statement by himself. The effect of these communications was by no means so overpowering as Sachs had expected. Roosevelt, wearied by the prolonged effort of listening to his visitor, made an attempt to disengage himself from the whole affair. He told the disappointed reader that he found it all very interesting but considered government intervention to be premature at this stage.

Sachs, however, was able, as he took his leave, to extort from the President the consolation of an invitation to breakfast the following morning. "That night I didn't sleep a wink," Sachs remembers. "I was staying at the Carlton Hotel [two blocks north of the White House]. I paced restlessly to and fro in my room or tried to sleep sitting in a chair. There was a small park quite close to the hotel. Three or four times, I believe, between eleven in the evening and seven in the morning, I left the hotel, to the porter's amazement, and went across to the park. There I sat on a bench and meditated. What could I say to get the President on our side in this affair, which was already beginning to look practically hopeless? Quite suddenly, like an inspiration, the right idea came to me. I returned to the hotel, took a shower and shortly afterwards called once more at the White House."

Roosevelt was sitting alone at the breakfast table, in his wheel chair, when Sachs entered the room. The President inquired in an ironical tone:

"What bright idea have you got now? How much time would you like to explain it?"

Dr. Sachs says he replied that he would not take long.

"All I want to do is to tell you a story. During the Napoleonic wars a young American inventor came to the French Emperor and offered to build a fleet of steamships with the help of which Napoleon could, in spite of the uncertain weather, land in England. Ships without sails? This seemed to the great Corsican so impossible that he sent [Robert] Fulton away. In the opinion of the English historian Lord Acton, this is an example of how England was saved by the shortsightedness of an adversary. Had Napoleon shown more imagination and humility at that time, the history of the nineteenth century would have taken a very different course."

After Sachs finished speaking the President remained silent for several minutes. Then he wrote something on a scrap of paper and handed it to the servant who had been waiting at table. The latter soon returned with a parcel which, at Roosevelt's order, he began slowly to unwrap. It contained a bottle of old French brandy of Napoleon's time, which the Roosevelt family had possessed for many years. The President, still maintaining a significant silence, told the man to fill two glasses. Then he raised his own, nodded to Sachs and drank to him.

Next he remarked: "Alex, what you are after is to see that the Nazis don't blow us up?"

"Precisely."

It was only then that Roosevelt called in his attaché, [Brigadier] General [Edwin] "Pa" Watson, and addressed him—pointing to the documents Sachs had brought—in words which have since become famous:

"Pa, this requires action!"

More on the challenges:

Teller criticizes as follows one of these excessively rosy views of the early history of the American atom bomb: 'There is no mention of the futile efforts of the scientists in 1939 to awaken the interest of the military authorities in the atomic bomb. The reader does not learn about the dismay of scientists faced with the necessity of planned research. He does not find out about the indignation of engineers asked to believe in the theory and on such an airy basis to construct a plant.'

Wigner remembers the resistance. 'We often felt as though we were swimming in syrup,' he remarks. Boris Pregel, a radium expert, without whose disinterested loan of uranium the first experiments al Columbia University would have been impossible, comments: 'It is a wonder that after so many blunders and mistakes anything was ever accomplished at all.' Szilard still believes today that work on the uranium project was delayed for at least a year by the short-sightedness and sluggishness of the authorities. Even Roosevelt's manifest interest in the plan scarcely accelerated its execution. ...

Saturday, May 20, 2017

This is a rare 1999 documentary about Ellis. It mixes interviews with dramatizations of scenes from his writing. The American Psycho bits are terrible, especially compared to the actual movie, which was released in 2000. Rewatching the movie today, my main reaction is that Bale is simply brilliant as Patrick Bateman: e.g., Hip to be Square (reprised by Huey Lewis himself here).

Before American Psycho came out, 25 years ago this month, it was already the most controversial novel of the Nineties. Its vivid depictions of gruesome murders of women, men, children and animals preceded wherever it went. The original publisher dropped it and told author Bret Easton Ellis to keep the money — but to please go away. The New York Times titled its book review "Snuff This Book!" On the opposite coast, Los Angeles Times begrudgingly wrote that "Free Speech Protects Even an 'American Psycho.'" The National Organization of Women attempted to organize boycotts. Stores refused to order it. And Ellis, who turned 27 around its release, received death threats. ...

Has the way that Patrick Bateman has become a cult character surprised you?
What if I said, no? [Pause.] I'm kidding [laughs]. Of course, it was surprising to me. American Psycho was an experimental novel. I wasn't really quite sure, nor did I care, how many copies it was going to sell. I really didn't care who connected with it.

Why is that?
I created this guy who becomes this emblem for yuppie despair in the Reagan Eighties – a very specific time and place ...

... Beginning in the Eighties, men were prettifying themselves and in ways they weren't. And they were taking on a lot of the tropes of gay male culture and bringing it into straight male culture — in terms of grooming, looking a certain way, going to the gym, waxing, and being almost the gay porn ideals. You can track that down to the way Calvin Klein advertised underwear, a movie like American Gigolo, the re-emergence of Gentlemen's Quarterly. All of these things really informed American Psycho when I was writing it. So that seemed to me much more interesting than whether he is or is not a serial killer, because that really is a small section of the book. ...

... Patrick Bateman, who was obsessed with Donald Trump, would likely be pretty happy with his campaign.
Or would he be embarrassed? Trump today isn't the Trump of 1987. He's not the Trump of Art of the Deal. He seemed much more elitist in '87, '88. Now he seems to be giving a voice to white, angry, blue-collar voters. I think, in a way, Patrick Bateman may be disappointed by how Trump is coming off and who he's connecting with.

To the guys that I was talking to in the Eighties when I was researching American Psycho, Donald Trump was an aspirational figure. That's why the jokes are throughout the book. It wasn't like I pulled that out of my hat; that was happening. And so I just thought it was funny that "OK, well, Patrick Bateman's gonna be obsessed with Donald Trump. He's gonna want to aspire to be Donald Trump." And I don't know if he would think that today. ...

Thursday, May 18, 2017

Almost everything we hear from the media these days is simply motivated reasoning -- i.e., partisan nonsense.

Wikipedia: ...When people form and cling to false beliefs despite overwhelming evidence, the phenomenon is labeled "motivated reasoning". In other words, "rather than search rationally for information that either confirms or disconfirms a particular belief, people actually seek out information that confirms what they already believe."

HIRONO: So if the Attorney General or senior officials at the Department of Justice opposes a specific investigation, can they halt that FBI investigation?

COMEY: In theory yes.

HIRONO: Has it happened?

COMEY: Not in my experience. Because it would be a big deal to tell the FBI to stop doing something that -- without an appropriate purpose. I mean where oftentimes they give us opinions that we don't see a case there and so you ought to stop investing resources in it. But I'm talking about a situation where we were told to stop something for a political reason, that would be a very big deal. It's not happened in my experience.

Tuesday, May 16, 2017

Pitts is one of the least studied geniuses of the early information age. See also Wikipedia, Nautil.us.

Cabinet Magazine: There are no biographies of Walter Pitts, and any honest discussion of him resists conventional biography. Pitts was among the original participants in the mid-century cybernetics conferences, though he began his association with that group of scientists when he was only a teenager. His intellectual strengths contributed to some central cybernetic theories reliant on logical structures and universal elements. Yet the sketchy details of his life provide the kind of evidence that resists the structure of those theories.

The mid-century cybernetics conferences, or Macy Conferences (1946-53), theorized about automatic or self-balancing systems in biological and technological ecologies. Warren McCullough, Norbert Weiner, John von Neumann, Margaret Mead, and Gregory Bateson were among those invited, and their discussions mixed methodologies and evidence from a broad range of disciplines including anthropology, neurophysiology, mathematics, logic, and computational networks. ...

Pitts entered into the company of this group as mysteriously as he left it. None of his colleagues knew very much about him. He came from a reportedly troubled working class family in Detroit and entered McCullough's home as a live-in collaborator when he was only seventeen. Even at this early age, he had already worked with prominent scientists in logic and mathematical biology. Three years later in 1943, he co-authored, with Warren McCullough, a theory of neurophysiological organization that would provoke sustained debate throughout the years of the cybernetics conferences. The paper proposed a logical structure for neural nets as coded circuitry, thus supporting machinic theories of mind as well as ambitions involving artificial intelligence. Pitts was only in his 20s during the cybernetics conferences of the 1940s and though he was an autodidact, he had already mastered or could almost instantly absorb the subject matter from the several fields of study engaged by the conferences. Not only did he circulate among prominent scientists, but those scientists either rivaled for his collaboration or deeply valued his critique and commentary. Pitts could, without fail, identify errors in logical thinking and he simply did not pursue information or discourse outside of the realm of logic. He considered the search for universal elements of mental structure to be not just a species of speculation, but a hard science of the brain and the mind. ...

Several of the scientists and psychiatrists of the group thought Pitts was schizophrenic and potentially very ill. The prominent psychiatrists who moved in his circles were more and more baffled by his reclusive shyness and his apparent personal discomfort. Later Pitts began to live on his own in Cambridge where he may have experimented with homemade drugs. No one seems to know much about his later life. He died in 1969 and some have speculated that he committed suicide. ...

Overview: In 1943 Warren S. McCulloch, a neuroscientist, and Walter Pitts, a logician, published "A logical calculus of the ideas immanent in nervous activity" in the Bulletin of Mathematical Biophysics 5:115-133. In this paper McCulloch and Pitts tried to understand how the brain could produce highly complex patterns by using many basic cells that are connected together. These basic brain cells are called neurons, and McCulloch and Pitts gave a highly simplified model of a neuron in their paper. The McCulloch and Pitts model of a neuron, which we will call an MCP neuron for short, has made an important contribution to the development of artificial neural networks -- which model key features of biological neurons.

The original MCP Neurons had limitations. Additional features were added which allowed them to "learn." The next major development in neural networks was the concept of a perceptron which was introduced by Frank Rosenblatt in 1958. Essentially the perceptron is an MCP neuron where the inputs are first passed through some "preprocessors," which are called association units. These association units detect the presence of certain specific features in the inputs. In fact, as the name suggests, a perceptron was intended to be a pattern recognition device, and the association units correspond to feature or pattern detectors.

This is an old interview with McCulloch. Nature vs Nurture and IQ starting at ~4min ;-)

Nautil.us: ... Thus formed the beginnings of the group who would become known as the cyberneticians, with Wiener, Pitts, McCulloch, Lettvin, and von Neumann its core. And among this rarified group, the formerly homeless runaway stood out. “None of us would think of publishing a paper without his corrections and approval,” McCulloch wrote. “[Pitts] was in no uncertain terms the genius of our group,” said Lettvin. “He was absolutely incomparable in the scholarship of chemistry, physics, of everything you could talk about history, botany, etc. When you asked him a question, you would get back a whole textbook … To him, the world was connected in a very complex and wonderful fashion.”

... In a letter to the philosopher Rudolf Carnap, McCulloch catalogued Pitts’ achievements. “He is the most omniverous of scientists and scholars. He has become an excellent dye chemist, a good mammalogist, he knows the sedges, mushrooms and the birds of New England. He knows neuroanatomy and neurophysiology from their original sources in Greek, Latin, Italian, Spanish, Portuguese, and German for he learns any language he needs as soon as he needs it. Things like electrical circuit theory and the practical soldering in of power, lighting, and radio circuits he does himself. In my long life, I have never seen a man so erudite or so really practical.” Even the media took notice. In June 1954, Fortune magazine ran an article featuring the 20 most talented scientists under 40; Pitts was featured, next to Claude Shannon and James Watson. Against all odds, Walter Pitts had skyrocketed into scientific stardom.

... If you look at any thread about Trump, Islam or immigration on a Chinese social media platform these days, it’s impossible to avoid encountering the term baizuo, or literally, the ‘white left’. It first emerged about two years ago, and yet has quickly become one of the most popular derogatory descriptions for Chinese netizens to discredit their opponents in online debates.

So what does ‘white left’ mean in the Chinese context, and what’s behind the rise of its (negative) popularity?

The question has received more than 400 answers from Zhihu users, which include some of the most representative perceptions of the 'white left'. Although the emphasis varies, baizuo is used generally to describe those who “only care about topics such as immigration, minorities, LGBT and the environment” and “have no sense of real problems in the real world”; they are hypocritical humanitarians who advocate for peace and equality only to “satisfy their own feeling of moral superiority”; they are “obsessed with political correctness” to the extent that they “tolerate backwards Islamic values for the sake of multiculturalism”; they believe in the welfare state that “benefits only the idle and the free riders”; they are the “ignorant and arrogant westerners” who “pity the rest of the world and think they are saviours”.

Apart from some anti-hegemonic sentiments, the connotations of ‘white left’ in the Chinese context clearly resemble terms such as ‘regressive liberals’ or ‘libtards’ in the United States. In a way the demonization of the ‘white left’ in Chinese social media may also reflect the resurgence of right-wing populism globally. ...

The term first became influential amidst the European refugee crisis, and Angela Merkel was the first western politician to be labelled as a baizuo for her open-door refugee policy. Hungary, on the other hand, was praised by Chinese netizens for its hard line on refugees, if not for its authoritarian leader. ...

Chenchen Zhang has a PhD in Political Theory from LUISS Guido Carli University and a PhD in Political Science from Université libre de Bruxelles. She has worked as a post-doctoral researcher at the University of Copenhagen.

Wednesday, May 10, 2017

The past year or so has seen a true explosion in both the capabilities and adoption of artificial intelligence technologies. Today’s generalized AI tools can solve specific problems more powerfully than the complex rule-based tools that preceded them. And, because these new AI tools can be deployed in many contexts, more and more applications and industries are ripe for transformation with AI technologies.

By drawing from the best posts on the O’Reilly AI blog, this in-depth report summarizes the current state of AI technologies and applications, and provides useful guides to help you get started with deep learning and other AI tools.

In six distinct parts, this report covers:

The AI landscape: the platforms, businesses, and business models shaping AI growth; plus a look at the emerging AI stack

Tuesday, May 09, 2017

Geneticist (Blair Underwood): Keep in mind, this child is still you -- simply the best of you. You could conceive naturally a thousand times and never get such a result ...

According to this discussion, an offer of genetic editing didn't make the final cut:

In an outtake to the movie, the geneticist states that for an extra $5,000 he could give the embryo enhanced musical or mathematical skills – essentially splicing in a gene that was not present on the parents’ original DNA.

Abstract
Genetic factors are estimated to account for at least 20% of the variation across individuals for educational attainment (Rietveld et al., 2013). The results of the latest GWAS for educational attainment identified 74 genome-wide significant loci for educational attainment (Okbay et al., 2016). Here, in one of the largest GWAS to date, we increase our sample to nearly 750,000 individuals, and we identify over 600 genome-wide significant loci associated with the number of years of schooling completed. Note that at the time of presentation, we will likely have updated our meta-analysis to include over 1,000,000 individuals

In this presentation, I will focus on the biological implications of the GWAS results. At the time of writing, 1,656 genes are significantly prioritized, a more than 10-fold increase since our previous report (Okbay et al., 2016). The newly significant results reinforce the biological theme of prenatal brain development and also bring to the foreground new themes that shed light on the biological underpinnings of cognitive performance and other traits affecting educational attainment.

One of the difficulties in genomics is that when DNA donors are consented for a study, the agreements generally do not allow sharing (aggregation) of genomic data across multiple studies. This leads to isolated silos of data that can't be fully shared. However, computations can be performed on one silo at a time, with the results ("summary statistics") shared within a larger collaboration. Most of the leading GWAS collaborations (e.g., GIANT for height, SSGAC for cognitive ability) rely on shared statistics. Simple regression analysis (one SNP at a time) can be conducted using just summary statistics, but more sophisticated algorithms cannot. These more sophisticated methods can generate a better phenotype predictor, using less data, than a SNP by SNP analysis.

A successful implementation like the one described at the link above could produce many (several times!) more hits and significantly more variance accounted for by corresponding predictors. Stay tuned!

Note Added: I'm getting lots of questions about how to interpret these results, so here are some comments.

1. I predicted ~10k variants would account for most of the heritability due to common SNPs (i.e., about 50% of total variance; allowing a predictor which correlates ~0.7 with actual cognitive ability). The rate of discovery of genome-wide significant hits and corresponding variance accounted for seems consistent with this prediction. Genetic associations are most easily discovered for variants which are common (e.g., have ~0.5 Minor Allele Frequency, not 0.05) and have large effect sizes. But alleles with this combination of properties are rare. As statistical power increases, one starts to discover (more and more) variants of lower frequency and/or lower effect size. A reasonable guess at the genetic architecture suggests a higher density of such variants, and is consistent with an accelerating rate of discovery of SNP hits (~100 hits from 300k individuals, ~600 hits from 750k). There are more efficient methods that, I believe, would discover nearly all the variants given sample size of ~1M well-phenotyped individuals. But these methods require more than just summary statistics.

I made a similar prediction of ~10k variants for height, and our (unpublished) genomic prediction results make me fairly confident that this will turn out to be correct. We now have moderately good height predictors and they are getting better very fast. That ~10k variants will turn out to be responsible for most of the variation in cognitive ability is still at a somewhat lower confidence level.

2. People are still confused about how many + variants above the mean in the population are required to make a "genius" (or super-genius). I managed to compress the explanation enough to fit in a tweet:

You can see that even if cognitive ability is controlled by ~10k variants, flipping only ~100 of them is enough to cause a big difference in actual intelligence. Flipping a few hundred could get us to super-geniuses beyond anything in human history.

3. If you read press accounts related to our creation of the BGI Cognitive Genomics Lab back in 2011 (at that time there were zero genome-wide significant alleles associated with intelligence), you can find quotes from genomics "experts" asserting that mankind would never discover the genetic architecture of cognitive ability. (Such quotes are easy to obtain even today!) A Bayesian update given what is known in 2017 would call into question the competence of these "experts"! ;-)

Wednesday, May 03, 2017

New York Magazine seems to have dedicated an entire issue to the Alt-Right. If you don't recognize any of this subterranean internet stuff you should probably have a look. Somehow they left out the Illuminati, though.

... what follows here is an attempt to really reckon with the alt-right and its fellow travelers: to organize and catalogue influences, philosopher-kings, and shit-posting foot soldiers; to track the movement’s history, its future, and the story of how the modern internet made it possible; to study its grievances, its media savvy, its symbols, its heroes and villains, its president and its critics of the president, its billionaire supporters and the underemployed message-board-dwelling “advocates” who serve as its creative engine. The movement is not a monolith — though it would also never be mistaken for a rainbow coalition — and part of what we’ve focused on is just how the various wings work together in concert. How does Steve Bannon relate to Russia Today, and what do conspiracy theorists have in common with pickup artists and Nazi Furries? How do memes like milk become weaponized, and just when did 4chan get political? How do its beliefs get amplified into the larger culture?

For all its theoretical anti-modernity, the alt-right is a uniquely modern movement, after all, enabled in reach by the connective tools of the social internet and by the clever use of the sort of irony that every young American raised on TV and memes recognizes as our pop-culture lingua franca. It’s an irony they’ve used as armor, too: If you take them seriously, they’ll claim you missed the joke. But of course, by treating them as a joke, you can miss their importance ...

... people who believe that the future of our species involves shedding our humanity in a marriage with AI; this is known as transhumanism, and it has not unreasonably been called a new tech religion. Though the movement has no explicit political affiliations, it tends, for reasons that are probably self-explanatory, to draw a disproportionate number of Silicon Valley libertarians. And the cluster of ideas at its center — that the progress of technology will inevitably render good ol’ Homo sapiens obsolete; that intelligence, pure computational power, is to be pursued above all other values — has exerted a powerful attraction on a small group of futurists whose extreme investment in techno-libertarianism has pushed them over an event horizon into a form of right-wing authoritarianism it might be useful to regard as Dark Transhumanism.

One of the authors pointed me to the interesting paper below, which contains a proposal meant to improve the reliability of scientific research (specifically in some areas such as social science or biomedicine). Could this proposal work if, say, it were strongly supported by scholarly associations and funding agencies?

Note the authors' use of "Crises of Confidence" in their title. I believe that certain areas of science really should be experiencing a crisis of confidence, if only their practitioners were smarter and more honest. But in fact I suspect it's mostly business as usual, even in the research areas with the lowest (and best documented as lowest) replication rates.

... This paper proposes and puts into practice a novel and simple mechanism that allows mutually beneficial gains from trade between original investigators and other researchers. In our mechanism, the original investigators, upon completing their initial study, write a working paper version of their study. While they do share their working paper online, they do however commit not to submit it to any journal for publication, ever. The original investigators instead offer co-authorship of a second paper to other researchers who are willing to independently replicate the experimental protocol in their own research facilities.2 Once the team is established, but before beginning replications, the replication protocol is pre-registered at the AEA experimental registry, and referenced in the first working paper. This is to guarantee that all replications, both successful and failed, are properly accounted for, eliminating any concerns about publication biases. The team of researchers composed by the original investigators and the other scholars will then write and coauthor a second paper, which will reference the original unpublished working paper, and submit it to an academic journal. Under such an approach, the original investigators accept to publish their work with several other coauthors, a feature that is typically unattractive to economists, but in turn gain a dramatic increase in the credibility and robustness of their results, should they replicate. Further, the referenced working paper would provide a credible signal about the ownership of the initial research design and idea, a feature that is particularly desirable for junior scholars. On the other hand, other researchers would face the monetary cost of replicating the original study, but would in turn benefit from coauthoring a novel study, and share the related payoffs. Overall, our mechanism could critically strengthen the reliability of novel experimental results and facilitate the advancement of scientific knowledge.