Schlüsselwörter

Nierentransplantation Cyclosporin A Konversionstherapie

Conversion from conventional immunosuppressive therapy to cyclosporin A in the early course after renal transplantation

Summary

From February through September 1983, before general Cyclosporin A (Cy-A) treatment, we changed 12 patients from conventional immunosuppression (including ATG) to Cy-A in the first 30 days after cadaver-donor kidney transplantation, due to rejection. This regimen was effective in 11 cases, the median follow-up now being 11 months. We conclude that early conversion therapy (including ATG) is as effective as primary Cy-A treatment. At present, we start with conventional immunosuppression in cases of long cold ischemia time (> 30 h) because of Cy-A nephrotoxicity in ATN kidneys, and change over to Cy-A after the graft is sufficiently functioning.