Tyler and Anna Mayfield have just relocated from Nebraska to the sun scorched desert town of Wormwood, Nevada. They find themselves in a strange new landscape populated with old school cowboys, alien cultists, meth dealers, and doomsday prophets. Loneliness and desperation pervade Wormwood, and when a meteorite lands in the center of town, its fragile existence begins to unravel as many believe the end of the world is near, while others simply seek a reason to believe in anything at all.