OTTAWA -- The Ottawa Senators regained the lead in the Eastern Conference finals with a convincing 5-1 victory over the Pittsburgh Penguins at Canadian Tire Centre on Wednesday night.

Mike Hoffman, Marc Methot, Derick Brassard, Zack Smith and Kyle Turris scored for the Senators, who now lead the best-of-seven series 2-1.

Sidney Crosby replied for the Penguins, who trailed 5-0 after two periods.

The Senators chased Penguins starting goalie Marc-Andre Fleury with four goals on nine shots in the first 12:52. Fleury was replaced by Matt Murray, who made 19 saves.

Craig Anderson made 25 shots in the Senators net. He lost his bid for a shutout when Crosby deflected a Phil Kessel shot though his legs at 6:07 of the third.

Hoffman opened the scoring at the 48-second mark, banking a shot in off Fleury from behind the goal line for his fifth goal of the playoffs.

Methot made it 2-0 at 10:34, taking a short pass from Bobby Ryan at the side of the net, then banging home his own rebound after his initial shot was stopped.

Brassard converted a setup by Clarke MacArthur into an open side at 12:28, and Smith chased Fleury 24 seconds later when he grabbed the puck behind the net and slid home a backhand on the wraparound.

Turris made it 5-0 when he scored on the 12th shot against Murray at 18:18 of the second period, grabbing the puck after Hoffman's attempt was blocked and cutting across the front to backhand home his fourth of the playoffs.

NOTES: The Senators set a franchise playoff record by scoring three times in a span of 2:18. ... Senators D Marc Methot scored for the second time in eight games after going goalless for more than a year. ... The Penguins went with seven defensemen, adding veterans Trevor Daley and Mark Streit with Justin Schultz out. Daley was injured in Game 5 of the second-round series against Washington. Streit appeared in his first game of the playoffs. ... Schultz, injured RW Bryan Rust and injured RW Patric Hornqvist all skated Wednesday morning.