Clinical usefulness of inverse ratio ventilation

Patients are not comfortable during inverse ratio ventilation as it is not a physiological pattern. In consequence, patients ventilated in this particular mode usually require heavy sedation and sometimes muscle paralysis.

Many recent studies have compared the short-term effects of inverse ratio ventilation (commonly used in pressure-controlled modes) on gas exchange, lung mechanics, and hemodynamics in patients with acute lung injury with those obtained when conventional volume-controlled ventilation is used. When maintaining the same total PEEP and minute ventilation for both modes, these studies did not find major differences in either arterial oxygenation or hemodynamics ( Lessard.ef a/.. 1994). Additionally, the static lung mechanics remained unchanged.

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