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Abstract

PHYTOCHEMICAL AND BIOLOGICAL STUDY OF ALEURITOPTERIS ANCEPS

Chandrakala Parajuli* and Prof. Dr. Dharma Prasad Khanal

ABSTRACT

This study was carried out to investigate phytochemical and biological
study of Aleuritopteris anceps, also known as Rani sinka. The whole
plant was collected from Kathmandu and Lalitpur district about 1300
m altitude in june-july and subjected to hexane, ethyl acetate and
methanol extraction by maceration process. The phytochemical study
revealed the presence of alkaloids, saponins, glycosides, terpenoids,
tannins, carbohydrates and phenols. The biological study was done for
antioxidant (by DPPH scavenging method), antimicrobial sensitivity
test (by cup plate method) and anti-diabetic activity (by oral glucose
tolerance test in glucose loaded rats). Antioxidant activity was
considerable with IC50 value 29.22 μg/ml, 147.48 μg/ml and 453.67μg/ml methanol, ethyl
acetate and hexane respectively. Antimicrobial activity was considerable to Gram positive
bacteria Staphylococcus aureus and Bacillus cereus Gram negative bacteria Salmonella typhi
but not at the concentrations of 100 mg/ml against Escherichia coli. The hypoglycemic effect
of 200 mg/kg and 400mg/kg methanol extract was found to be 26.23% and 26.79%
respectively where as standard drug Glimeperide showed 32.52%. This study concludes that
it could serve as a source of potent antioxidant, antimicrobial and anti-diabetic agents.
Therefore this study can be basis for the further research to find out more detail information
regarding the relationship between antioxidant activity and other phytochemical content
which may help to highlight the chemicals which are responsible for this activity.