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Criminal enterprises operating globally - so-called "Transnational Criminal Organizations" -- have spent years refining their approaches to all types of illicit trafficking including narcotics, weapons, illicitly gained and laundered money, and even modern day slavery. In many ways, these organizations can be considered multi-national corporations, given their size, reach, and sophistication. Indeed, their production and logistics operations rival best practices in the commercial sector, with highly resilient supply chains driven by the need to minimize the risk of seizure. TCOs often directly and indirectly enable, support, and facilitate insurgencies and terrorism; undermine state stability, security, and sovereignty; and corrupt legitimate global financial and trade networks. The stakes are high. U.S. Law Enforcement, Homeland Security, and the Department of Defense (DoD) find themselves at the front lines of this global security issue. As criminal organizations adapt to traditional interdiction methodologies, stakeholders across government are coming together to stem the tide, looking at what new technologies and whole of government approaches can be brought to bear to address this complex threat.