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This case report demonstrates a correlation between PIB retention in the living human brain and amyloid pathology at autopsy. It provides further support for the possibility of using this imaging technique to detect and track fibrillar amyloid pathology in the living human brain. Future studies will determine the extent to which PIB and other imaging techniques could be used in the diagnosis, preclinical detection, and tracking of Alzheimer disease and the evaluation of promising amyloid-modifying therapies.