Research Description

Description of Research
Research in our laboratory is concerned with the design of small-molecule agents for the cure and management of life-threatening diseases and for probing and modulating gene regulation. Structurally novel drugs and drug conjugates are prepared using organic and inorganic synthetic methodologies. The interactions of these agents with potential biomolecular targets (DNA, DNA-processing enzymes, metalloenzymes) are studied using bioanalytical (LC-MS) and high-resolution structural (NMR, X-ray) methods, as well as biophysical and molecular biology techniques. Biological activity studies are carried out in vitro and in vivo by collaborators at WFU School of Medicine. Our research is funded through the National Institutes of Health.