A football midfielder, Cesar Osvaldo La Paglia, began playing football professionally in 1996, with Argentinos Juniors. He was sold to Boca Juniors soon enough, and went on to bag four titles with the club, including 1998 Apertura, 1999 Clausura, the 2000 and 2003 Apertura tournament titles. Paglia furthermore went on to win the Copa Libertadores in 2002, with the club.

In 2001, Paglia shifted to Talleres de Cordoba, though he returned to Boca in two years, which was when he won the international title. His next move was to Spanish club, CD Tenerife, where he remained till 2006, at which point he moved to Vitoria F.C., and then the very next season to Independiente Medellin.

In 2008, Paglio was signed by Chinese club, Wuhan Guanggu, during the transfer window which opened in January. But he was released by the club in May, after which he moved to Uruguay to play for Defensor Sporting. In 2009, Paglia returned to Argentina where he joined his current club San Martin de Tucuman.