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World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar. Best Paper Award : Dr. Muhammad Baqir MR Fakhrildin
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Ginger (Zingiber officinale) is used in traditional medicine in
management of many conditions including bacterial infections.
Usually, many people use traditional medicinal plants in combination
with many antibiotics for treatment of many bacterial infections, this
may lead to herbal- drug interactions, this herbal- drug interactions
may cause a decrease or an increase of antibiotic action, as well as it
may be no herbal- drug interactions, so our study was held to test
possible interactions between Z. officinale rhizomes and some selected
antibiotics (amoxicillin and cefixime). The study was conducted in
vitro by using well diffusion method against Staphaylococcus aureus
and Eischerichia coli. The results revealed that, the ethanolic extract of
Z. officinale has good anti- bacterial activity against S. aureus (mean growth inhibition zone
20.35 mm) and no activity against E. coli. The anti- bacterial activity of cefixime against S.
aureas and E. coli was good with mean growth inhibition zones 34.35 mm and 40.2 mm
respectively. When Z. officinale extract was combined with cefixime, the growth inhibition
zones were decreased (when compared with the activity of cefixime alone) against S. aureas
and E. coli (antagonistic effect), the growth inhibition zones were 29.95 mm and 35.05 mm
respectively (P- value < 0.01). The mean growth inhibition zones of amoxicillin against S.
aureas and E. coli were 15.15 mm and 30.05 mm respectively, while the combination of Z.
officinale extract with amoxicillin gave no change on the mean growth inhibition zone
against E. coli (30.05 mm), but the same combination against S. aureas showed no anti- bacterial activity which was considered as antagonistic effect (P- value < 0.01). We concluded that Z. officinale rhizomes should better be avoided in combination with anti- bacterial agents. Also we recommend that researchers should enter the field of herbal- drug interactions researches, for testing the combination effects between many medicinal plants that are used traditionally with known therapeutic agents used in treatment of various diseases.