Mymethazine Fortis
Molecular Weight

Mymethazine Fortis
Melting Point

Mymethazine Fortis
H2O Solubility

Mymethazine Fortis
State

Mymethazine Fortis
LogP

Mymethazine Fortis
Dosage Forms

Tablet; Suppository; Opthalmic drops; Syrup

Mymethazine Fortis
Indication

For the treatment of allergic disorders, itching, nausea and vomiting.

Mymethazine Fortis
Pharmacology

Promethazine, a phenothiazine, is an H1-antagonist with anticholinergic, sedative, and antiemetic effects and some local anesthetic properties. Promethazine is used as an antiemetic or to prevent motion sickness.

Mymethazine Fortis
Absorption

On average, 88% of a promethazine dose is absorbed after oral administration; however, the absolute bioavailability is only 25% because of first-pass clearance.

Mymethazine Fortis
side effects and Toxicity

Symptoms of overdose include mild depression of the central nervous system and cardiovascular system to profound hypotension, respiratory depression, unconsciousness, and sudden death. Other reported reactions include hyperreflexia, hypertonia, ataxia, athetosis, and extensor-plantar reflexes (Babinski reflex). LD50=55mg/kg (I.V. in mice)