On June 3, 2010, Alimera Sciences, Inc. (the Company) issued a press release and is holding
a conference call regarding its results of operations and financial condition for the first quarter
ended March 31, 2010. The full text of the press release is furnished as Exhibit 99.1 to this
Current Report on Form 8-K.

Various statements to be made during the conference call are forward-looking statements,
within the meaning of the Private Securities Litigation Reform Act of 1995, regarding, among other
things, the Companys future results of operations and financial position, business strategy and
plans and objectives of management for the Companys future operations. Words such as
anticipate, believe, estimate, expect, intend, may, plan, predict, project,
likely, will, would, could, and similar expressions are intended to identify
forward-looking statements, although not all forward-looking statements contain these identifying
words. The events and circumstances reflected in the Companys forward-looking statements may not
occur and actual results could differ materially from those projected in the Companys
forward-looking statements. Meaningful factors which could cause actual results to differ include,
but are not limited to, delay in or failure to obtain regulatory approval of the Companys product
candidates, uncertainty as to the Companys ability to commercialize, and market acceptance of, the
Companys product candidates, the extent of government regulations, uncertainty as to the
relationship between the benefits of the Companys product candidates and the risks of their
side-effect profiles, dependence on third-party manufacturers to manufacture the Companys product
candidates in sufficient quantities and quality, uncertainty of clinical trial results, limited
sales and marketing infrastructure, as well as other factors discussed in the Companys Securities
and Exchange Commission filings, including the Companys final prospectus filed under Rule
424(b)(4) with the Securities and Exchange Commission in connection with the Companys initial
public offering.

All forward-looking statements made during the conference call are expressly qualified by the
above paragraph in their entirety. These forward-looking statements speak only as of the date of
the conference call (unless another date is indicated). The Company undertakes no obligation, and
specifically declines any obligation, to publicly update or revise any forward-looking statements
which are made during the conference call, whether as a result of new information, future events or
otherwise.

The information in Item 2.02 of this Current Report on Form 8-K and the press release attached
hereto as Exhibit 99.1 shall not be deemed filed for purposes of Section 18 of the Securities
Exchange Act of 1934 (the Exchange Act) or otherwise subject to the liabilities of that section,
nor shall it be deemed incorporated by reference in any filing under the Securities Act of 1933, as
amended, or the Exchange Act, except as expressly set forth by specific reference in such a filing.