Detailed entry information

Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum, ER via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export. Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis, By similarity. {ECO:0000250, ECO:0000269|PubMed:11149926, ECO:0000269|PubMed:7876246}.