Haldol News

WARNING

Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death. Analyses of seventeen placebo-controlled trials (modal duration of 10 weeks), largely in patients taking atypical antipsychotic drugs, revealed a risk of death in drug-treated patients of between 1.6 to 1.7 times the risk of death in placebo-treated patients. Over the course of a typical 10-week controlled trial, the rate of death in drug-treated patients was about 4.5%, compared to a rate of about 2.6% in the placebo group. Although the causes of death were varied, most of the deaths appeared to be either cardiovascular (e.g., heart failure, sudden death) or infectious (e.g., pneumonia) in nature. Observational studies suggest that, similar to atypical antipsychotic drugs, treatment with conventional antipsychotic drugs may increase mortality. The extent to which the findings of increased mortality in observational studies may be attributed to the antipsychotic drug as opposed to some characteristic(s) of the patients is not clear. HALDOL Decanoate is not approved for the treatment of patients with dementia-related psychosis (see WARNINGS).

HALDOL SUMMARY

Haloperidol decanoate is the decanoate ester of the butyrophenone, HALDOL (haloperidol). It has a markedly extended duration of effect.

Clinical Trials Related to Haldol (Haloperidol)

Ketamine Versus Haloperidol for Severe Agitation Outside the Hospital [Not yet recruiting]
This research study is being done to find out if one of two drugs, ketamine or haloperidol,
is better for treating agitation. Agitation is a state of extreme emotional disturbance
where patients can become physically aggressive or violent, endangering themselves and those
who are caring for them. Often chemical substances or severe mental illness is involved in
this level of agitation. Specifically, the investigators are interested in studying
agitation that is treated in the prehospital setting by paramedics. This study's hypothesis
is that ketamine is superior to haloperidol for treatment of agitation in the prehospital
environment.

Lamictal TM, Haloperidol Decanoate in Schizophrenia [Terminated]
The purpose of this study is to determine the effect of lamotrigine augmentation of
Haloperidol decanoate in the treatment of Resistant Schizophrenia predominantly by verbal
resistant hallucinosis: A randomized, double-blind, placebo-controlled, study.
Nadir A. Aliyev & Zafar N. Aliyev
Central Mental Clinic for Outpatients of Baku city of Azerbaijan Republic
Abstract:
OBJECTIVE: The current paper reports on a double-blind, randomized study of the
role of lamotrigine as an augmentation agent to haloperidol decanoate in the treatment
of out patient's schizophrenia with verbal resistant hallucinosis.

PATIENT REVIEWS / RATINGS / COMMENTS

Based on a total of 1 ratings/reviews, Haldol has an overall score of 10. The effectiveness score is 10 and the side effect score is 10. The scores are on ten point scale: 10 - best, 1 - worst.

Haldol review by medical professional caring for 23 year old female patient

Rating

Overall rating:

Effectiveness:

Highly Effective

Side effects:

No Side Effects

Treatment Info

Condition / reason:

psychotic out nof control patient

Dosage & duration:

5mg taken given on a prn basis for the period of given on a prn basis

Other conditions:

borderline personality disorder

Other drugs taken:

ativan,

Reported Results

Benefits:

Was able to gain control after receiving the injection form of the medication.Was helpful in decreasing aggitation,psychosis,delusions.At the end of the required time in seclusion and after giving medication time to take effect patient was able to return to facility population without any further problems.Was able to maintain in a calm manner,much less aggitated and was able to meet to staff to discuss delional ideas.

Side effects:

Drownsy but no untoward effects.Patient was able to be put on routine dose of this medication after effectivness of medication was evaluated to help prevent further problems.When routine dosage was begun patient was given routine medications for any side effects.

Comments:

Patient became aggiatated,delusional and psychotic and needed to be medicated for safty of patient and others.Required seclusion for decrease stimuli for mediation to take effect.Patient was medicated and given the quiet of seclusion and was monitored for saftey.At the end of seclusion time was released and placed back into the facility mileu.