7463 – Advanced manufacturing process for high throughput, large scale
nanomedicine production
Background:
A
number of therapeutic and diagnostic nanoparticles (NP), or nanomedicines, have
been developed for targeted delivery of drugs and imaging agents for the
treatment of major diseases. However, only a small number of these NPs have
been approved by the FDA due to low reproducibility of... Read More

6467 – Background: Microencapsulation of cells in semi-permeable polymer networks is a promising approach for avoiding immunosuppressive therapy in allogeneic, xenogeneic and genetically modified cell transplantation. Current technology uses an electrostatic droplet generator and alginate-based polymers. Major drawbacks to this system are that cellular microspheres are limited to larger diameter... Read More

4729 – A 2D microfluidic device with “sticky” regions for containing and mixing fluids.
Background: Lab-on-a-chip, or microfluidic devices, are highly sought after in life sciences research and diagnostic applications. Current devices are either bulky and three dimensional or lack the ability to confine fluids to a specific area for testing. Thus, there is a need for a device with a simple... Read More

5430 – Background: Craniosynostosis is the premature fusion of the cranial suture early in development. If left untreated, blindness, deafness, and delays in development can occur. The current treatment for craniosynostosis uses surgery to remove the fused area and remodel the skull. In up to 40% of patients, the skull re-fuses; necessitating additional surgery that often results in death or... Read More

7054 – Background: There is an increasing demand for microbial detection in the food industry due to enhanced regulatory, quality, and compliance programs. Detection of low concentrations of bacteria is challenging at best with current assays. The food industry is continuously searching for improved tools that are faster, more accurate and more sensitive than traditional methods.
Technology:... Read More

7089-5691 – Background:
There
is a large interest in understanding how biologic systems use external cues and
transduce them into physiologic functions. On the cellular level, extracellular
chemicals trigger an intracellular signal transduction pathway that results in
a physiological function. The cellular microenvironment is highly dynamic and
involves complex, temporally varying chemical signals. In... Read More

4514 – This technology integrates sensors and electronics for use in biological experiments and clinical diagnostics.
Background: Early detection is essential in effective cancer treatment. Many different sensor technologies are under development for this purpose and for a variety of other chemical and biological sensing applications. However, there is a need for these sensors to be packaged... Read More