Suitable for use in FC, IP, ELISA, Neut, FuncS, IF and most other immunological methods.

Specificity

Tested positive against native antigen.

Purity

>95.0% as determined by Analysis by RP-HPLC & analysis by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Background

Introduction

This monoclonal antibody can be attached to the chelator pentetic acid (DTPA) linked to the tripeptide glycine (G) – L-tyrosine (Y) – L-lysine (K), which chelates Indium 111 and binds selectively to cell-surface TAG-72 expressed on colorectal tumors. This product has the same active ingredient as Satumomab Pendetide.

Antigen Description

The majority of human adenocarcinomas including colorectal, pancreatic, gastric, ovarian, endometrial, mammary, and non-small cell lung cancer display some cell populations that are positive for TAG72. About 60% of carcinoma patients express TAG72 in their sera. TAG72 is reportedly useful in distinguishing pulmonary adenocarcinomas from pleural mesotheliomas.