I have an seo website that is #1 in my area, I have changed the design of the website at least 3 times without seeing any negative effects. I believe as long as the wording and the structure remain the same there is no reason for SE's to frown on a theme change.

It may change. Some themes are optimised and thus it could contribute to your ranking in the Search Engine Results Page. If your website has a good backlink portfolio, I would not expect a major change in your rankings.

I lost first page rankings for weeks, until I build some more web 2.0 profiles and blasted them... Then page came back again... Just remember your site is cached within Google. If google see's a change they will have to re-cache the page or entire site again. Just heads up.

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