Meladinin - General Information:

A naturally occurring furocoumarin compound found in several species of plants, including Psoralea corylifolia. It is a photoactive substance that forms DNA adducts in the presence of ultraviolet A irradiation. [PubChem]

Meladinin - Pharmacology:

After activation it binds preferentially to the guanine and cytosine moieties of DNA, leading to cross-linking of DNA, thus inhibiting DNA synthesis and function.

Meladinin for patients

Patients should be told emphatically to wear UVA-absorbing, wrap-around sunglasses and cover exposed skin or use a
sunblock (SP 15 or higher) for the twenty-four (24) hour period following treatment with methoxsalen, whether exposed
to direct or indirect sunlight in the open or through a window glass.