It is often thought that tumor Ktrans value
differences correspond to changes in capillary contrast agent (CA) permeability. We show this is not the case for implanted
glioma in rat brain. Over an almost eight-fold
Ktrans change, the tumor CA extravasation rate constant kpe
remains relatively fixed, as if regulated, but at a value greater than
normal. The Ktrans changes
reflect cerebral blood volume fraction changes.

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