Carriers of APOE-4 allele have a 2-3 fold risk of
developing Alzheimer's. difference in APOE4 brain structure are known for 50 years
old, and for glucose metabolism in 20 years old normal subjects. Here, 52
healthy Ashkenazi Jews (ages 20-35), were genotyped and underwent MRI
protocol including DTI, T1 and T2. ANOVA statistics revealed that T1 VBM and
DTI and T2maps VBA indicate significant differences between APOE33\23 (29,8)
and APOE34 (11) in the parahippocampal gyrus, the hippocampus and the globus
pallidus, the orbitofrontal cortex, and the dorsolateral prefrontal cortex.
Our findings implicate that APOE affects the brain since developmental
stages.