Overview

My research focuses on the molecular events underlying neurodegeneration in Alzheimer’s disease (AD). Among other neuropathological features, cortical deposition of an insoluble material, called amyloid, occurs in both the aging and the AD-afflicted brain. I am interested in identifying the cellular pathways regulating the generation of the toxic beta-amyloid protein (Abeta), and the factors involved in the subsequent neurodegenerative process associated with this peptide.

We have shown that ACAT inhibitors have reduced generation of Abeta in cell-based models of AD and dramatically improved brain pathology in a transgenic mouse model of AD. We are currently synthesizing and testing novel ACAT inhibitors.

Another major project concerns the physiological functions of presenilin/gamma-secretase and BACE1, the two enzymes that play a pivotal role in the generation of Abeta. Most recently, we established a signaling pathway involving both of these enzymes and regulating the activity of voltage-gated sodium channels in the brain. We are now examining how sodium channel dysfunction may contribute to AD pathology.

Research Projects

ACAT Inhibitors and New Alzheimer's Disease Drug TherapiesTherapies already developed for atherocyltransferase (ACAT) inhibitors, drugs specifically targeting one step of the cholesterol pathway, are being actively devesclerosis and cardiovascular disease are currently being considered for AD. Acyl-coenzyme A: cholesterol aloped for treatment of cardiovascular disease.

We have shown that ACAT inhibitors have reduced generation of Abeta in cell-based models of AD and dramatically improved brain pathology in a transgenic mouse model of AD. We are currently synthesizing and testing novel ACAT inhibitors. Our overarching goal is to provide evidence that would strongly encourage clinical trial of ACAT inhibitors for AD.

Presenilin/Gamma-secretase and BACE1, and Sodium Channel Dysfunction

This major project concerns the physiological functions of presenilin/gamma-secretase and BACE1, the two enzymes that play a pivotal role in the generation of Abeta. Most recently, we established a signaling pathway involving both of these enzymes and regulating the activity of voltage-gated sodium channels in the brain. We are now examining how sodium channel dysfunction may contribute to AD pathology.