Summary: The preparation Ukrain was studied in
order to confirm its theoretically substantiated properties in comparison with
amitozin as its structural and functional analogue, and two other functional
analogues, namely methisazone (against herpesvirus and poxvirus) and remantadine
(against grippevirus). The experiments were carried out on albino Swiss mice
of either sex weighing initially 18-20 g. They were kept at room temperature
(20-21°C) on a natural day-night cycle, were housed in groups of ten per
cage and had free access to food and water. The Ukrain preparation's activity
as concerns grippe virus of A type (England) 42/72 (H3N2) was determined in
ovo and in vivo, the treatment beginning 2 h after infection. The control animals,
infected by appropriate virus dose, were injected with placebo. For the activities
of the remedies investigated, our estimate was based on the median duration
of life in the mice of the subexperimental and control groups (duration of experiments
14 days), the degree of intensity of pulmonary tissue changes, and the difference
in median HR titres. The totality of Chelidonium majus alkaloids, thiophosphamide
(the alkalizing agent), the sum of alkaloids modified by thiotepa, and some
other alkaloids as their alkalized derivatives, all showed a statistically reliable
inhibiting effect. The most significant biological activity was demonstrated
by Ukrain as concerns the models of viral processes, and by the sum of alkaloids
and amitozin as concerns the models of associated infections. This coincides
with the results of biological assessment of modified products (1,3,5) with
metabolites, alkaloids in particular, or alkaline substances.