Russia's Defense Ministry said the areas captured by Syrian government troops include 10 neighborhoods and over 3,000 buildings

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This photo provided by the Syrian Civil Defense White Helmets, which has been authenticated based on its contents and other AP reporting, shows Civil Defense workers and Syrian citizens inspect damage buildings after airstrikes hit the Seif al-Dawleh neighborhood in Aleppo, Syria, Saturday, Nov. 19, 2016. Government bombardment of besieged rebel-held neighborhoods in the northern city of Aleppo killed at least 20 people Saturday Syrian opposition activists said, a day after the health directorate said all hospital in opposition areas have been knocked out of service.

Syrian government forces and their allies captured a major eastern Aleppo neighborhood and several smaller areas Monday, putting much of the northern part of Aleppo's besieged rebel-held areas under government control, state media reported.

Russia's Defense Ministry said the areas captured by Syrian government troops include 10 neighborhoods and over 3,000 buildings. The ministry said in a statement that more than 100 rebels have laid down their arms and exited the Syrian city's eastern suburbs.

Aleppo, Syria's largest city and former commercial center, has been contested since the summer of 2012 and a rebel defeat in the city would be a turning in the five-year conflict. If Syrian forces capture all of east Aleppo, President Bashar Assad's government will be in control of the country's four largest cities as well as the coastal region.

The government's push, backed by thousands of Shiite militia fighters from Lebanon, Iraq, and Iran, and under the occasional cover of the Russian air force, has laid waste to Aleppo's eastern neighborhoods.

Syria's state news agency SANA said government forces captured the Sakhour neighborhood early Monday morning.

Rami Abdurrahman, who heads the Britain-based Syrian Observatory for Human Rights, said Syrian government forces have captured some 10 neighborhoods over the past few days, putting nearly 30 percent of Aleppo's formerly rebel-held neighborhoods under state control.

State TV said 3,000 people, half of them children, have fled over the past few hours. It showed men, women and children in green buses being taken to government-controlled areas.

"It is stinging cold, food is scarce and people are shaken in the streets," Mohammad Zein Khandaqani, a member of the Medical Council in Aleppo, told The Associated Press in a voice text message from east Aleppo.

He added that some residents are taking refuge in mosques while others moved to homes of displaced people in safer areas.

He said although thousands of people have fled to government or Kurdish-controlled areas in Aleppo, many stayed because they are wanted by the state.

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The Russian Defense Ministry also said Syrian government troops had pushed the rebels from Qadisia which it described as the "key neighborhood of eastern Aleppo."