I've been curious for a long time and have not been able to find an answer.
I love my nuked pepperoni and cheese! What does micowaving do to the nutritional content??
I even emailed hormel at one point and asked what micowaving did to the content. Seeing all the oil left behind on the paper towel, it MUST change the calorie and fat content, right??
Anyone know?

You could probably weigh the paper towel before you microwave it, then weigh it after and use the weight difference as grams of fat removed from the pepperoni (or bacon).
That would be very rough because more than just the fat would render out, some would be water or other things (I think, I'm not a food scientist lol).