Methods: :
A retrospective consecutive series of 95 eyes with NAMD requiringSDOCT (Cirrus) imaging for routine clinical care were includedin this study. The images were acquired by the 512X128 volumescan protocol. SDOCT scanning was performed by highly experiencedtechnicians certified for obtaining images for multiple clinicaltrials. The data from each eye was evaluated for artifacts affectingCSFT such as boundary line errors (BLE), scan decentration (SDC),Z offset error, eye movement artifact, and other artifacts.BLE involving > 50% of retinal thickness in at least 5 contiguousB scans were considered significant. SDC was identified whenthe center of the macula was not located within the centralsubfield (decentered by at least 500 microns). Software toolswere used to correct BLE and SDC to generate corrected CSFT.

Results: :
BLE were present in 76 (80%) of scans of which 18 (23%) weresignificant. SDC occurred in 9 scans (9.4%). Both SDC and significantBLE were seen in 3 (3%) scans. Mean CSFT change with BLE correctionand/or grid re-centration was 66µ; BLE alone 86µ,SDC alone 28µ and both 85µ.

Conclusions: :
Artifacts are frequent in SDOCT scans in NAMD and may resultin large variance from the correct measurement. Image qualityevaluation is an important step in interpretation of the CSFTin NAMD.