Set in Springfield, the average American town, the show focuses on the antics and everyday adventures of the Simpson family; Homer, Marge, Bart, Lisa and Maggie, as well as a virtual cast of thousands. Since the beginning, the series has been a pop culture icon, attracting hundreds of celebrities to guest star. The show has also made name for itself in its fearless satirical take on politics, media and American life in general.

In "The Thing and I," Bart discovers his evil Siamese twin in the attic. In "The Genesis Tub," Lisa's science experiment becomes a quickly-developing micro-universe, where she is thought of as God and Bart is the devil. In "Citizen Kang," aliens replace Clinton and Dole just in time for the election.

When Homer accepts a job offer, the Simpsons move to Cypress Creek, where everything seems too good to be true. Finally happy at his job, Homer fails to notice that his new boss is an evil megalomaniac bent on world domination.

A hurricane destroys the Flanders' home and they have to move into the church basement. The people of Springfield gather to rebuild their house, but when Ned sees the poor workmanship, he has a complete breakdown.