Weitere Antikörper gegen RMI2 Interaktionspartner

In both patient and knockout cell lines reduced localisation of BLM to ultra fine DNA bridges and FANCD2 at foci linking bridges are observed. Overall, loss of RMI2 produces a partially active BLM complex with mild features of Bloom syndrome.

The results show that Topo IIIalpha stimulates DNA unwinding by BLM in a manner that is potentiated by RMI1 (zeige RMI1 Antikörper)-RMI2, and that the processivity of resection is reliant on the Topo IIIalpha-RMI1 (zeige RMI1 Antikörper)-RMI2 complex.