We produce video courses that are viewed in desktop arrangements, (15”-30”) or on large LED monitors (30”+ to 75”) or projected (10’ to 30’+)…. They have to be kept at high quality because of the text and graphic info. They are usually played directly off the hard drive or a USB-3 flash stick (never streamed).
Our masters that we export to Adobe Media Player are 1920X1280 or 1280X720 Cineform 10bit uncompressed files or exported directly off the Premiere CC 2014 timeline….. Our current setting for 1920X1080p is as below. Other than the high bit rate (too keep the picture from looking fuzzy or getting pixel blocking) is this the best setting layout? Can anyone recommend any improvements or suggestions? Please help! Thank you very much.

If final file size isn't a big deal (since you're playing from a hard drive or thumb drive) then get rid of 2-pass VBR (Variable bit rate). Do a CBR and set the data rate at 16mpbs.

You can also shorten you keyframe distance down to your frame rate (or even half your frame rate). Typically I do keyframe distance at the frame rate - 24, 30, 60, etc. That way every second I'm guaranteed an I-frame as it encodes.

In the export panel under the Multiplexer tab check that stream compatibility is set to Standard. You might also consider increasing the target bitrate to 20-24 Mbps or higher; the 1280p equivalent to Blu-ray quality would be about 40-42 Mbps.