Engineered biomimetic platforms

OBJECTIVES

Our goal is to control the binding of active molecules on 2D platforms for studying cellular responses in vitro. Thanks to the use of surface sensitive techniques the functionalization of our platforms is quantitatively controlled and studies on molecular interactions are allowed. The 2D platforms are, moreover, used as substrate for cellular studies such as differentiation, migration and signaling activation. We are in particular looking at the effect of a glicosamminoglycan named heparan sulfate on bone morphogenetic protein 2 activity on murine and human stem cells.