Chlorpheniramine, dextromethorphan, and phenylephrine is used to treat sneezing, cough,
runny or stuffy nose, itchy or watery eyes, hives, skin rash, itching, and other symptoms of
allergies and the common cold.

Dextromethorphan will not treat a cough that is caused by smoking, asthma, or
emphysema.

Chlorpheniramine, dextromethorphan, and phenylephrine may also be used for purposes
other than those listed in this medication guide.

What is the most important information I should know about
chlorpheniramine, dextromethorphan, and phenylephrine?

Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children.
Do not use a cough or cold medicine if you have used an MAO inhibitor such as
isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam),
or tranylcypromine (Parnate) within the past 14 days. Serious, life-threatening side effects can
occur if you take cough or cold medicine before the MAO inhibitor has cleared from your body.
Do not use any other over-the-counter cough, cold, allergy, or sleep medication
without first asking your doctor or pharmacist. If you take certain products together you may
accidentally take too much of one or more types of medicine. Read the label of any other
medicine you are using to see if it contains an antihistamine, decongestant, or cough suppressant.
Chlorpheniramine, dextromethorphan, and phenylephrine can cause side effects that
may impair your thinking or reactions. Be careful if you drive or do anything that requires you to
be awake and alert.
Avoid drinking alcohol. It can increase some of the side effects of this medication.

What should I discuss with my healthcare provider before taking
chlorpheniramine, dextromethorphan, and phenylephrine?

Do not use a cough or cold medicine if you have used an MAO inhibitor such as
isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam),
or tranylcypromine (Parnate) within the past 14 days. Serious, life-threatening side effects can
occur if you take cough or cold medicine before the MAO inhibitor has cleared from your body.

Before taking this medication, tell your doctor if you are allergic to chlorpheniramine,
dextromethorphan, or phenylephrine, or if you have:

kidney disease;

liver disease;

diabetes;

glaucoma;

heart disease or high blood pressure;

diabetes;

a thyroid disorder;

a stomach ulcer or a stomach obstruction,

emphysema or chronic bronchitis; or

an enlarged prostate or urination problems.

If you have any of these conditions, you may not be able to use
chlorpheniramine, dextromethorphan, and phenylephrine, or you may need a dosage adjustment
or special tests during treatment.

FDA pregnancy category C. This medication may be harmful to an unborn baby. Tell
your doctor if you are pregnant or plan to become pregnant during treatment.
Chlorpheniramine, dextromethorphan, and phenylephrine can pass into breast milk
and may harm a nursing baby. Do not use this medication without telling your doctor if you are
breast-feeding a baby.

Artificially-sweetened liquid forms of cough-and-cold medications may contain
phenylalanine. This would be important to know if you have phenylketonuria (PKU). Check the
ingredients and warnings on the medication label if you are concerned about phenylalanine.

How should I take chlorpheniramine, dextromethorphan, and
phenylephrine?

Use this medication exactly as directed on the label or as it was prescribed for you. Do
not take the medication in larger amounts, or take it for longer than recommended by your
doctor.

Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children.
Take this medicine with a full glass of water. If you use the effervescent tablet, drop
the tablet in 8 ounces of water and allow it to dissolve completely. Stir this mixture and drink all
of it right away. To make sure you get the entire dose, add a little more water to the same glass,
swirl gently and drink right away.

Measure the liquid form of this medicine with a special dose-measuring spoon or cup, not
a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist where
you can get one.

Take this medicine with food or milk if it upsets your stomach.

This medication can cause you to have unusual results with allergy skin tests. Tell any
doctor who treats you that you are taking an antihistamine.

Talk with your doctor if your symptoms do not improve after 7 days of treatment, or
if you have a fever with a headache, cough, or skin rash.

If you need to have any type of surgery, tell the surgeon ahead of time if you have taken a
cold medicine within the past few days.

Store the medication at room temperature away from moisture and heat.

What happens if I miss a dose?

Since cough or cold medicine is usually taken only as needed, you may not be on a dosing
schedule. If you are taking the medication regularly, take the missed dose as soon as you
remember. If it is almost time for your next dose, skip the missed dose and take the medicine at
your next regularly scheduled time. Do not take extra medicine to make up the
missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this
medicine.

What should I avoid while taking chlorpheniramine, dextromethorphan, and
phenylephrine?

This medication can cause side effects that may impair your thinking or reactions.
Be careful if you drive or do anything that requires you to be awake and alert.
Avoid drinking alcohol. It can increase some of the side effects of this medication.

Avoid using other medicines that make you sleepy (such as cold medicine, pain
medication, muscle relaxers, and medicine for seizures, depression or anxiety). They can add to
sleepiness caused by chlorpheniramine, dextromethorphan, and phenylephrine.

Avoid taking diet pills, caffeine pills, or other stimulants (such as ADHD medications)
without your doctor"s advice. Taking a stimulant together with a decongestant can increase your
risk of unpleasant side effects.

Do not use any other over-the-counter cough, cold, allergy, or sleep medication
without first asking your doctor or pharmacist. Antihistamines, decongestants, and cough
suppressants are contained in many medicines available over the counter. If you take certain
products together you may accidentally take too much of one or more types of medicine. Read
the label of any other medicine you are using to see if it contains an antihistamine, decongestant,
or cough suppressant.

What are the possible side effects of chlorpheniramine, dextromethorphan,
and phenylephrine?

Get emergency medical help if you have any of these signs of an allergic
reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop using this medication and call your doctor at once if you have any of these
serious side effects:

There may be other drugs that can affect chlorpheniramine,
dextromethorphan, and phenylephrine. Tell your doctor about all the prescription and
over-the-counter medications you use. This includes vitamins, minerals, herbal products, and
drugs prescribed by other doctors. Do not start using a new medication without telling your
doctor.

Where can I get more information?

Your pharmacist has information about chlorpheniramine, dextromethorphan, and
phenylephrine written for health professionals that you may read.

What does my medication look like?

Chlorpheniramine, dextromethorphan, and phenylephrine is available over-the-counter
under the brand name Cerose DM. Other brand or generic formulations may also be available.
Ask your pharmacist any questions you have about this medication, especially if it is new to you.

Remember, keep this and all other medicines out of the reach of children, never share
your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ("Multum") is accurate,
up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum
information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not
warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum"s drug information does
not endorse drugs, diagnose patients or recommend therapy. Multum"s drug information is an informational resource designed to assist
licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not
a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or
drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any
given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information
Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug
interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse
or pharmacist.