Abstract : In the context of the DISPATMO project study of the forecast of the risks of pollution related to the atmospheric dispersal of chemicals, risk studies linked to the fires and the explosions due to chemical storage were conducted. The purpose is to identify the combustion products of certain target compounds defined at the beginning of the project, as well as to estimate their concentration. The target compounds include ethanol, 2-butanone, toluene and the solvent TIFLEX. These compounds lead, especially in fuel-rich conditions, to the formation of high quantities of butene isomers, compounds known as important intermediates of hydrocarbon combustion. After a bibliographical study on butene isomers, ethanol, 2- butanone and toluene, a detailed kinetic mechanism for the simulation of the oxidation of these compounds was proposed. An experimental study of the oxidation of the butene isomers was performed in a jet-stirred reactor T = 900-1440 K, p = 1 atm, = 0.25, 0.5, 1 and 2, = 70 ms and in a spherical combustion chamber Ti = 300 K, pi = 1, 2, 3 and 5 atm, = 0.8-1.4. Experimental results were compared with their simulations. Experimental data from the literature were used to validate the model for the oxidation of ethanol, 2-butanone, toluene and butene isomers. Finally, an experimental study of the oxidation of the solvent TIFLEX was performed in the jet-stirred reactor T = 740-1310 K, p = 1 atm, = 0.5, 1 and 2 in order to know the composition as well as to identify and quantify of the oxidation products. The proposed kinetic mechanism contains a strong C0-C4 base, resulting in a reliable predictive tool, which can be used as a base in larger mechanisms simulating the combustion other species alkanes, alkenes, alcohols, aldehydes or ketones, by addition of sub-mechanisms.