BACKGROUND: Herbal medicines have been used since ancient times as drugs for treatment of a range of diseases and have represented stimulatory effects on the function of innate immunity.

OBJECTIVE: To evaluate the effects of Zataria multiflora (Z. multiflora) on the function of innate immunity including phagocytic activity and TNF-alpha secretion in animal model.

METHODS: BALB/c mice were divided into 2 groups with 8 mice: group A (mice administered with Z. multiflora essence intraperitoneally), group B (mice administered with distilled water intraperitoneally).Blood was taken from 4 mice in each group at days 4 and 7 after injection phagocytic activity and TNF- alpha secretion were assayed by chemiluminescence and ELISA methods, respectively.

RESULTS: The results of chemiluminescence and ELISA tests showed significant increasing in phagocytic activity and TNF-alpha secretion of group A in compare with control group at days 4 and 7.

CONCLUSION: Z. multiflora essence can stimulate remarkably innate immunity function and it may be used to immunize individuals as prophylactic and/or therapeutic adjuvant alone or in combination with other immunostimulatory agents.

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