Officers from Shepparton's Divisional Tasking Unit and Criminal Investigation Unit carried out the search warrant this morning alongside forensic police members from Melbourne.

Police could be seen taking dozens of large cannabis plants and hydroponic growing equipment from the house, which appeared unkept and poorly maintained.

Sgt Frost said police were working to establish whether the house was linked to three other cannabis crop houses that were raided in Shepparton and Mooroopna in January last year.

Police could not give an exact number of how many plants were seized during the raid and could not put a dollar value on the amount.

A neighbour, who said he had never seen anyone coming or going from the house, said the front garden of the home had been unkept for the past two years.

He and his wife both noticed something "strange" at the address, with his wife eventually calling the police around a month ago.

“My wife noticed something and a bit of a pungent smell, so she rang the police and that's pretty much how it started,” he said.

“The house stands out, especially in this well-kept neighbourhood. I was actually spraying weed killer on the front yard because it started to become a bit overgrown and there was no one coming or going.

“We thought they were maybe doctors or nurses because it's not a normal house to be doing that in, or neighbourhood as such — it's strange.”

Sgt Frost confirmed no-one was home at the time of the raid, with police continuing to investigate who was responsible for the illegal set-up.