NIH-Funded Study in Mice Shows Beneficial Effect of Dust Microbe

Source

University of California, San Francisco

What

A new study suggests that exposure to dust from homes with dogs may alter the immune response to allergens and other asthma triggers by affecting the composition of the gut microbiome—the community of microbes that naturally colonize the digestive tract. The findings, published inProceedings of the National Academy of Sciences, help demonstrate how environmental exposures may protect against airway allergens and asthma. The study, led by researchers at the University of California, San Francisco; the University of Michigan; Henry Ford Health System in Detroit; and Georgia Regents University in Augusta, was supported by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health.

Previously, the researchers found that infants who live in homes with dogs are less likely to develop childhood allergies. They later showed that dust collected from homes with dogs contains a wider range of bacteria types than dust gathered from homes without pets. In the current study, they show that dog-associated house dust can play a key role in preventing allergic inflammation. Feeding young mice dust from a home with a dog protected the animals against airway inflammation triggered by cockroach allergen. Compared to mice fed dust from a pet-free home or those not exposed to dust, mice exposed to dog-associated dust had fewer of the cells and immune-modulating chemicals involved in allergic responses. The researchers obtained similar results when they exposed dust-fed mice to a different allergen.

In addition, the investigators found that exposing mice to dog-associated dust altered the composition of the mouse gut microbiome. Specifically, the animals’ lower intestines contained high levels of the bacterium Lactobacillus johnsonii. Feeding mice live L. johnsonii reduced inflammation triggered by cockroach allergen or infection with respiratory syncytial virus, two risk factors for childhood asthma. These results suggest potential new strategies to prevent and treat certain allergic diseases and lung infections.

Who

Alkis Togias, M.D., Chief of the Allergy, Asthma and Airway Biology Branch in NIAID’s Division of Allergy, Immunology and Transplantation, is available to comment on the findings.