Can deuterium-depleted water be produced at home?

Not at all in a significant way. Home distillers can achieve a maximum 1 ppm decrease in deuterium level and would require the distillation process to be repeated multiple times to achieve a modest decrease. The freezing method is also inefficient.

Substantial decrease of deuterium content in water can only be achieved by an industrial scale fractional vacuum distillation technology.

Hydrohealth water contains 84% less deuterium than normal drinking water, whereas home methods alter the deuterium content of water by a mere 1-2%.