The 2000 NCAA Division I-A football season ended with the Oklahoma Sooners claiming their first national championship and their first conference championship since the departure of head coach Barry Switzer.

The BCS title game was not without controversy, as the system shut fourth-ranked Washington out of the championship game, despite being the only team who had beaten each #2 Miami and #5 Oregon State and having the same 10-1 record as #3 Florida State during the regular season. 10–1 Miami, who handed #3 Florida State their only loss, was ranked higher in both the AP Writers' Poll and the ESPN/USA Today Coaches' Poll, and had the same record as the Seminoles, was also seen as a possible title contender.

Virginia Tech also was left out of the BCS bowls, despite being ranked higher than one of the at-large teams, Notre Dame.

The South Carolina Gamecocks broke a 21-game losing streak, stretching back into 1998, to go 8–4 including a win over Ohio State in the Outback Bowl.

The following rules changes were passed by the NCAA Rules Committee in 2000:

The definition of an illegal block is expanded to include any high-low or low-high combination block by any two offensive players when the initial contact clearly occurs beyond the neutral zone.

Crack-back blocks are now prohibited from any offensive player in motion in any direction (previously it was in motion toward the ball) and the restricted zone is now 10 yards beyond the neutral zone in all directions.

Offensive teams in the process of substituting or simulated substituting are prohibited from rushing to the line of scrimmage to snap the ball to give the defense a disadvantage. The penalty for a first offense is five yards, additional violations are considered unsportsmanlike conduct (15 yards).

Defensive players lined up within one yard of the line of scrimmage are prevented from rushing up to the line with the obvious intent of causing an offensive player to false start.

Passers within five yards of the sideline from the original position of the ball (aka the "Tackle Box") are allowed to throw the ball so it lands beyond the neutral zone without penalty.