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Taking clindamycin sometimes results in an overgrowth of dangerous bacteria in the large intestine, according to MedlinePlus. This overgrowth can lead to inflammation in the large intestine, or colitis, which can be life-threatening. Symptoms such as watery or bloody stools, diarrhea, stomach cramps or fever should be reported to a physician immediately. It is possible for these symptoms to appear up to several months after taking clindamycin.

Other serious side effects that can occur while taking clindamycin include rash, hives, blisters and problems breathing or swallowing, states MedlinePlus. Yellowing of the skin or eyes and decreased urination may also occur. Patients who experience any serious side effects are advised to contact their physician immediately.

Less serious side effects may also result from treatment with clindamycin, such as heartburn, nausea, vomiting, joint pain and pain while swallowing, reports MedlinePlus. Other potential side effects include white patches in the mouth; white vaginal discharge; and burning, itching or swelling of the vagina.