Glaucoma surgery has incrementally advanced over the years. Initial surgical methods centered on the creation of a drainage fistula to lower IOP. These early procedures, such as full-thickness filtration and seton implantation using various foreign objects, had unacceptably high complication rates. The transition to guarded filtration surgery, which started in the late 1960s, has decreased postoperative complications, but scarring and failure over time have remained problematic. Adjunctive antifibrotic therapy with fluourouracil and mitomycin (MMC) was adopted as a means of reducing scar formation and increasing the likelihood of success, but with a tradeoff of increased postoperative complications