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Hashimoto's disease 1
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1. Hashimoto's disease (Hashimoto's thyroiditis, chronic lymphocytic thyroiditis)Hashimoto's disease is characterized by an insidious symmetrical enlargement of the thyroid , which becomes firm but not painful. Antithyroglobulin antibody and antimicrosomal antibody titers are usually high. Microscopically, thyroid acini are almost replaced by great numbers of B lymphocyte s. Unlike Grave's disease, there is no antibody against TSH receptors. Gradually, affected patients develop hypothyroidism . Incidence of thyroid antibodies in the serum increases with increasing age. In women above the age of 50, there is a peak incidence of about 25%, in men, it is about 10%.