STRING allows inspection of the interaction evidence for any given network. Choose any of the viewers above (disabled if not applicable in your network).

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:query proteins and first shell of interactors

white nodes:second shell of interactors

Node Content

empty nodes:proteins of unknown 3D structure

filled nodes:some 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

RSAG_01277

Uncharacterized protein (214 aa)

Predicted Functional Partners:

RSAG_01283

Precorrin-3B C17-methyltransferase (243 aa)

0.997

RSAG_01282

Precorrin-6x reductase (683 aa)

0.990

cbiA

Cobyrinic acid a,c-diamide synthetase ; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source (464 aa)

0.986

cobQ

Cobyric acid synthase ; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (502 aa)

0.979

RSAG_01284

Uncharacterized protein (373 aa)

0.976

RSAG_01285

Precorrin-4 C11-methyltransferase (258 aa)

0.973

RSAG_01279

Threonine-phosphate decarboxylase (347 aa)

0.951

cobD

Cobalamin biosynthesis protein CobD ; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (325 aa)

0.944

cbiD

Cobalt-precorrin-6A synthase ; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A (388 aa)

a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1

node2

node1 accession

node2 accession

node1 annotation

node2 annotation

score

RSAG_01277

RSAG_01279

RSAG_01277

RSAG_01279

Uncharacterized protein

Threonine-phosphate decarboxylase

0.951

RSAG_01277

RSAG_01282

RSAG_01277

RSAG_01282

Uncharacterized protein

Precorrin-6x reductase

0.990

RSAG_01277

RSAG_01283

RSAG_01277

RSAG_01283

Uncharacterized protein

Precorrin-3B C17-methyltransferase

0.997

RSAG_01277

RSAG_01284

RSAG_01277

RSAG_01284

Uncharacterized protein

Uncharacterized protein

0.976

RSAG_01277

RSAG_01285

RSAG_01277

RSAG_01285

Uncharacterized protein

Precorrin-4 C11-methyltransferase

0.973

RSAG_01277

RSAG_02255

RSAG_01277

RSAG_02255

Uncharacterized protein

Precorrin-2 C20-methyltransferase

0.919

RSAG_01277

cbiA

RSAG_01277

RSAG_01281

Uncharacterized protein

Cobyrinic acid a,c-diamide synthetase ; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source

0.986

RSAG_01277

cbiD

RSAG_01277

RSAG_01286

Uncharacterized protein

Cobalt-precorrin-6A synthase ; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A

0.940

RSAG_01277

cobD

RSAG_01277

RSAG_01280

Uncharacterized protein

Cobalamin biosynthesis protein CobD ; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group

0.944

RSAG_01277

cobQ

RSAG_01277

RSAG_01278

Uncharacterized protein

Cobyric acid synthase ; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation

0.979

RSAG_01279

RSAG_01277

RSAG_01279

RSAG_01277

Threonine-phosphate decarboxylase

Uncharacterized protein

0.951

RSAG_01279

RSAG_01282

RSAG_01279

RSAG_01282

Threonine-phosphate decarboxylase

Precorrin-6x reductase

0.772

RSAG_01279

RSAG_01283

RSAG_01279

RSAG_01283

Threonine-phosphate decarboxylase

Precorrin-3B C17-methyltransferase

0.712

RSAG_01279

RSAG_01284

RSAG_01279

RSAG_01284

Threonine-phosphate decarboxylase

Uncharacterized protein

0.779

RSAG_01279

RSAG_01285

RSAG_01279

RSAG_01285

Threonine-phosphate decarboxylase

Precorrin-4 C11-methyltransferase

0.749

RSAG_01279

RSAG_02255

RSAG_01279

RSAG_02255

Threonine-phosphate decarboxylase

Precorrin-2 C20-methyltransferase

0.594

RSAG_01279

cbiA

RSAG_01279

RSAG_01281

Threonine-phosphate decarboxylase

Cobyrinic acid a,c-diamide synthetase ; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source

0.913

RSAG_01279

cbiD

RSAG_01279

RSAG_01286

Threonine-phosphate decarboxylase

Cobalt-precorrin-6A synthase ; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A

0.714

RSAG_01279

cobD

RSAG_01279

RSAG_01280

Threonine-phosphate decarboxylase

Cobalamin biosynthesis protein CobD ; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group

0.984

RSAG_01279

cobQ

RSAG_01279

RSAG_01278

Threonine-phosphate decarboxylase

Cobyric acid synthase ; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation

0.994

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Network Stats

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Functional enrichments in your networkNote: some enrichments may be expected here (why?)

Enrichment analysis is still ongoing, please wait ...

Statistical background

For the above enrichment analysis, the following statistical background is assumed: