SINGAPORE: Collagen derived from fish scales could be used to heal wounds, according to a study conducted by researchers at the Nanyang Technological University (NTU) and National University of Singapore (NUS).

The study included fish scales from fishes that are commonly cooked such as sea bass, snakehead and tilapia.

The scales, usually removed before cooking, contain collagen that can be chemically modified to be water-soluble and used for various biomedical applications, NTU said in a press release on Monday (Mar 12).
The modified collagen can also incorporate drugs to produce wound dressings with a higher healing potential, according to the findings from the team comprising assistant professor Cleo Choong and associate professor Andrew Tan from NTU, and associate professor Veronique Angeli from NUS.

The modified collagen was later tested on mice and it was found that it helped improve the "potential for tissue repair and regeneration", according to the study was published in the research journal Acta Biomaterialia.

"Applying collagen dressings to a wound to stimulate tissue growth can provide relief for a wide variety of injuries.

"Collagen dressings come in all shapes and sizes – gels, pastes, powders and pads. It can potentially treat wounds of all dimensions,” said Dr Tan, who is from the NTU School of Biological Sciences.

The study also showed that fish scales-derived collagen was also easily obtained as 200mg of collagen could be extracted from one or two fish, and the extraction process costs just over S$4.

LOCAL FISHERIES TAKE PART IN RESEARCH

The research team partnered with a local fish farm that supplied the fish scales used in the study.

“We descale and sell over 200 fish a day to wholesalers, restaurants and walk-in customers. If these discarded fish scales can lead to successful biomedical applications in future, it would be a good use of these waste material," said the owner of KhaiSeng Trading & Fish Farm, Mr Teo Khai Seng.

The research team is also in talks with a few local fisheries to find ways to convert aquaculture waste material, like fish scales, into useful materials, as well as to scale-up the collagen extraction process for effective waste-to-resource management.

OTHER MEDICAL USES

Previous studies from the same team also highlighted the effects of fish scale-derived collagen on human umbilical vein endothelial cells. The cells produced 2.5 times more collagen responsible for blood vessel formation than cells cultured on other forms of collagen.

The findings have gained international attention as the collagen from non-mammalian sources could overcome the various biological and cultural issues associated with collagen from cattle and pigs.

"Clinical application of these materials has been limited due to cultural and religious restrictions associated with these mammalian tissue-derived materials.

"In addition, more checks and processing have to be in place due to the risk of diseases that can be transmitted from mammals to humans," said assistant professor Choong, who is from the NTU School of Materials Science and Engineering.

SINGAPORE — Fish scales and bullfrog skins containing collagen could be used to make wound dressings for burn victims or diabetic patients with chronic, slow-healing wounds in the not-too-distant future.

A study led by Nanyang Technological University (NTU) scientists found that the scales and skins — which contain collagen but are often thrown away — can be converted into useful materials.

Using chemical modification, the water-soluble collagen can be made into wound dressings in the form of gels, pastes, powders or pads that could be applied directly onto the skin, said NTU associate professor Andrew Tan, who is part of the team behind the study.

This could potentially treat wounds by promoting the growth of blood and lymphatic vessels, which improves the potential of tissue repair and regeneration.

Collagen dressings are typically suitable for different wound types, such as bed sores, minor burns, foot ulcers, chronic wounds and large open cuts.

While collagen is already “widely used for various biomedical applications”, most of the products that are commercially available come from animal sources like pigs, cows and sheep, said assistant professor Cleo Choong from the NTU School of Materials Science and Engineering.

They have limited clinical application due to “cultural and religious restrictions” associated with these mammal sources, she added. Greater checks and processing also have to be in place due to the risk of diseases that can be transmitted from mammals to humans.

Compared to cattle-based sources, collagen from fish scales has also been found to trigger human umbilical vein endothelial cells to produce 2.5 times more of a type of collagen that can boost blood vessel formation, according to a previous study by the same team of NTU scientists that was published in 2016.

Already, the team’s findings have drawn interest from some biomedical product manufacturing companies that are keen to turn to other non-mammal sources.

For the project, KhaiSeng Trading and Fish Farm supplied the researchers with fish scales from sea bass, snakehead and tilapia. Compared to cowhide, fish scales are cheaper and are usually removed from the fish before cooking.

About 200 milligrams of collagen can be derived from 10 grams of fish scales – the amount that can be obtained from one or two fishes.

Excluding labour costs, it costs about S$4 to extract about 100 mg of collagen from fish scales in the lab.

The team is currently in talks with two local fisheries, to convert aquaculture waste material into useful materials and scale-up the collagen extraction process.

A large amount of aquaculture waste is produced yearly, with aquaculture production expected to hit 102 million tonnes by 2025, according to the 2016 State of World Fisheries and Aquaculture report published by the United Nations’ Food and Agriculture Organisation.

Speaking to TODAY on Monday (March 12), research fellow Dr Wang Jun Kit said that the next step would involve tests on bigger animals and human trials – which could take five to six years – before the product can be commercially available.

“They could facilitate tissue growth and speed up the overall wound healing process, but we would need to do more research and testing in this area,” said Dr Wang, adding that the research process began since 2012.

His team is looking at other collagen sources, such as bullfrog skin, which is also commonly discarded.

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