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i think Oro looks like a human.. hes just got a weird skin pigment and a weird purple thingy around his eyes, Jiraiya has red stuff under his eyes, and Tsunade has a red dot on her forehead, its just part of the Sannin fashion

Naruto is a mythical world with evil scary guys (Orochimaru) and people that don't exist in the real world. You can't compare a fantasy world with the real world. Oro is referred as inhuman because his power excedees the normal human full strenght and because of his coldness and evil heart, and obviously because he looks like a snake (why? See below). A demon. Like Kisame who's just a human with shark face. Maybe everyone from his clan are shark faces Both Oro and Kisame are humans.

It's not really important this question, and of course it'll not be answered. Oro is just that way because he's evil (and the snake is often seen as an evil and- this is true- cold animal) and Hoshigaki Kisame has the face of a shark because he came from the Hidden Mist Village of the Water Country (water = shark).

Offspring-san is absolutely right about Oro. It's the same things with the 4 Sounds. Why they look like that? Just because they look, to make them scarier, simple like that.