Simultaneous
Estimation of T2, T2-Dagger and Lipid Content in Bone with a Novel Iterative
Algorithm

1Program in Applied Mathematics,
University of Arizona, Tucson, AZ, USA; 2Department of Radiology,
University of Cincinnati, Cincinnati, OH, USA; 3Department of
Radiology, University of Arizona, Tucson, AZ, USA

Bone marrow is a challenging region of the body for MR
imaging due to the presence of two chemical species, both fatty yellow bone
marrow and red bone marrow, as well as micro-trabeculae which cause significant
intra-voxel de-phasing (characterized by the time constant T2). In this work
we present a novel iterative algorithm which simultaneously provides estimates
of T2 to evaluate the bone architecture, as well as an estimate of the
relative lipid concentration and T2 of the water component for the
characterization of lesions using data acquired with the GRASE technique.