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Prurigo nodularis (PN) is a common dermatological disorder, manifested as scaly nodules which appear mainly on the extensor surfaces of the limbs. PN may appear secondarily to skin scratching in chronic hepatitis, liver cirrhosis, uremia, hypothyroidism etc. Nevertheless, in many cases no underlying physical disease is present. According to the literature, in fifty percent of the patients there is co-morbidity with depression, anxiety or somatoform disorders.

We hypothesize that a group of these patients may benefit from antidepressant therapy.

Detailed Description

Not Provided

Study Type ICMJE

Interventional

Study Phase

Not Provided

Study Design ICMJE

Intervention Model: Single Group AssignmentMasking: None (Open Label)

Condition ICMJE

Prurigo Nodularis

Intervention ICMJE

Drug: citalopram (cipralex)

10-20 mg/day, for 12 weeks.

Study Arms

Not Provided

Publications *

Not Provided

* Includes publications given by the data provider as well as publications
identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.

Recruitment Information

Recruitment Status ICMJE

Unknown status

Enrollment ICMJE

Not Provided

Completion Date

Not Provided

Primary Completion Date

Not Provided

Eligibility Criteria ICMJE

Inclusion Criteria:

prurigo nodularis

age: 18-70 years

agreed to participate

Exclusion Criteria:

younger than 18 or older than 70

pregnant or lactating women

chronic diseases: cancer, neurological disorders, diseases that are known to be associated with pruritus such as liver cirrhosis, uremia, etc.

sensitivity to cipralotam

psychosis, bi-polar disorder, substance addiction, use of antidepressant in the previous year

use of systemic therapies to prurigo nodularis such as thalidomide, cyclosporine

Sex/Gender

Sexes Eligible for Study:

All

Ages

18 Years to 70 Years (Adult, Senior)

Accepts Healthy Volunteers

Not Provided

Contacts ICMJE

Contact information is only displayed when the study is recruiting subjects