The Negative Effects of glyphosate – starting with its impact on the nervous system

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For those of you who missed the February 16 conference call with Jeffrey Smith interviewing Dr. Zach Bush, we have the links to the video and audio below, as well as a full transcript. Read and listen about the negative effects of glyphosate.

New: Glyphosate Dissolves Tight Junction Gut Barrier

This video shows glyphosate placed on small intestine cells in the lab at 10 parts per million (ppm) degrading the tight junctions cells of the gut barrier over a 16 minute period, demonstrating how glyphosate dissolves tight junction gut barrier. When RESTORE is placed on the same tight junction cells along with glyphosate, the tight junction barrier remains strong.

These statements (in the webinar) have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Webinar Video:

Jeffrey Smith: It’s because the glyphosate is essentially producing the zonulin, and the zonulin is creating the gaps, and what you’re saying Restore does is that it breaks down the zonulin. Does the Restore act on the glyphosate directly, or does it just act on the zonulin?

Part 3

Dr. Zach Bush: Both. We think it’s doing probably three or four things at once. I think it’s improving the breakdown of the glyphosate. I think it’s improving the mineral content of the gut there so that enzymes work better. The enzymes that break down toxins, including things like glyphosate, work better because of the trace mineral content within the product as well. I think it’s doing many different things here at once, but one of the most important is definitely the upregulation of the DPP4 enzymes that break down zonulin.

Let me show you what that looks like. Couple of slides forward here. This is what it looks like under the functional study here. Here’s your control membrane on the left. You add the herbicide. This is more like 40 parts per million, so this is like a pretty toxic meal from a fast food place or something like that where you would be exposed to that level. Just for the herbicide alone you’re seeing about a 60% drop in the resistance. But if you add back the communication network of the bacteria, with Restore, you’ll see that huge jump in resistance. Not only do you go back to where you were with the control, but you actually end up 30% better than you were.

We’ve done both studies where you can show that, you show this recovery with Restore in the tight junction system in the petri dish but you can also show the protection if you add Restore and herbicide at the same time, you never get that drop. You end up stronger than you did before without that drop happening.

Same thing with the gliadin, breakdown product of gluten. Get about 30% drop in gluten so gluten adds a toxin to the tight junction not nearly as potent as the herbicide, but gluten alone breaks down that tight junction system. Do Restore and gluten at the same time, you get no drop in resistance. The reason I think that you see the higher increase in improvement with Restore plus herbicide is the really cool feature of the human body. The more injury that it faces and the more challenge it faces, there’s more opportunity for remodeling and transformation of that system. Because the herbicide is such a potent injury, it actually requires more remodeling, restructuring, reproduction, until you actually end up way stronger than you did even to begin with as long as Restore is present. It’s an interesting interplay there between the gluten and herbicide that the body is so good at healing when it’s called into action.

This is what that looks like under a microscope. There’s your control. Here’s if you add Restore to the control. You can’t see this by your eye on the quality of slides we have here, but there’s about a 20% increase in integrity or expression of the tight junction system. Even if you take a completely healthy membrane, you can improve it by another 20-30% by adding the Restore. Take that control membrane and you add glyphosate, ten parts per million, huge unzippering of those cells, huge gaps, you’ve got floating cells. Add back Restore, they zipper right back up. It’s a very beautiful interplay. You can then go the other direction where you take the control, you add Restore, then you add glyphosate, no unbuckling of the cells at all. We’ve done both studies going both directions on this imagery here to show that effect.

Jeffrey Smith: How long does it last? This would be both in the petri dish and also in the body.

Dr. Zach Bush: Yeah, when we first launched the product in my clinic; this is back when I just had white bottles of the stuff that we were making by hand back in my lab attached to my clinic, one bottle at a time. It was a ridiculous process, but we had a little Sharpie marker that we had to write “one tablespoon, twice a day” to my patients. Because it looked like in the petri dish, we were experiencing about a 12-hour effect on that. I thought that twice a day was going to be adequate. Then we went into clinical efforts with kids with autism and they were the ones that really showed us much more accurately the half-life in a biologic system as complicated as the human gut. For them, we were seeing a half-life more around six hours. That’s when we went to three time a day optimal dosing or optimal usage for the product. That was maybe year, year and half ago.

Now the three-time-a-day usage is significant in those autistic kids. If they miss their middle-the-day dose because they’re at school or whatnot, they will be having more tantrums, more meltdowns by the end of the day then if they’ll get that midday use in. We’re really trying to get that three-time-a-day usage in, especially your sensitive populations, but for optimal use, the product you’re looking at is three times a day because the biologic half-life looks to be around that four to six hours.

Jeffrey Smith: Now, as I understand, the bottle says either take a tablespoon once a day, or better yet, take a teaspoon three times a day. If you take the larger dose at the beginning, does it last longer for more hours than if you took a teaspoon in the beginning?

Dr. Zach Bush: With the clinical use over the last four years, I would say probably not. I would much rather everybody takes tiny doses frequently than take one big dose a day. That said, one large dose a day, a tablespoon a day or something like that, you get an enormous amount of repair activity that way. There are definitely people out there that are just simply saying, “There is no way I’m going to be able to take something three times a day.” You can expect to get a great result still with a once a day usage, but really to get the full bang for the buck, you’re going to be taking that before each of your big meals.

Jeffrey Smith: Now, you said it does a lot of repair if you take a lot. If someone has a pretty serious issue, should they load up on a lot of it in the beginning and then go to the teaspoon three times a day, so that they can bring the gaps that are there, have a lot of surface area of this redox molecule all over the gut so it can do its job quickly, and then go to the normal dose? How would it look then?

Dr. Zach Bush: I like starting slow. This picture that you’re seeing here. These cells zipper together. The biologic consequences echo on and on and on. When you fix those tight junctions, you’re bringing about all kinds of different levels of healing in the body. It’s not because Restore is doing anything downstream, it’s actually your body’s doing all the work at that point. As soon as that tight junction system zips up and you lose all that oxidative stress at the gut membrane, your body now has every single organ system starting to repair because your immune system has reserve. It finally has a reserve of antioxidants and micronutrients, all kinds of things as that intelligent membrane comes back into play. You can expect really dramatic changes from really small use on the front end.

The more damaged your system is, the less you actually need to have those huge effects happen because your body is so sensitive and your body has made so many adaptive changes to handle the stress that you’re under. When you just start to zipper those cells shut, you’re going to see hydration happen like it hasn’t happened in decades. Rapid hydration leads to electrolyte changes, which can give you headaches, it can give you bloating, it can give you some fatigue, and so just the process of getting that cell repair happening at this fundamental level is going to trigger all kinds of things.

My individuals that are most damaged, which would be like my autistic kids or my patients with chronic autoimmune disease or patients with chronic Lyme disease who’ve seen a ton of antibiotics, all of them are going to start slow. You start at something as low as three drops, five drops, under the tongue a few times a day. Then you can work your way up over the course of a couple of weeks to the teaspoon few times a day.

For my patients that have really aggressive chronic inflammatory symptoms going forward, they can certainly increase the use above and beyond that teaspoon. We have patients that benefit from as much as two tablespoons a few times a day in pretty severe situations. Above that, we really haven’t seen much effect or benefit of going higher than that. Two tablespoons three times a day, that’s about the top of the tree, but I never really start there because, again, you’re making a big bang for the buck on the front end with small use and then you can increase until you find your optimal usage.

Jeffrey Smith: It’s exactly the opposite of what I said. I said if you’re really messed up you should take a lot up front and you said, “No, if you’re really having problems, take a little bit because the repair mechanism would give side effects that would be uncomfortable.” Thank you for that clarification. That was really important.

Now, also, does the Restore actually build up diversity of gut bacteria or do we still have the thin more monocultures, smaller amounts than we’re supposed to?

Dr. Zach Bush: Yes. This is the exciting thing is. When I started making this stuff, I put this into play clinically in cancer patients and within four days, I saw people with sterile guts. I don’t know if you’ve heard of this syndrome called white chalk stools, but our patients who had been on long-term chemotherapy and antibiotics for consequences of chemotherapy infections, etc. Best example of this is probably pancreatic cancer patients, they very commonly will develop these white chalk stools where they have no organic material left in the gut and all they’re passing is the epithelial lining of their intestines as stool volume. That turns out to be a small chunk of what looks like white chalk passing as stool every couple of days.

The first woman who went on this clinically was a pancreatic cancer patient. She started on the product and within four days had her first normal, large, brown bowel movement. Somehow we had recovered enough organic material and bacteria to give her normal bowel function in four days. That’s when I knew we had a really massive breakthrough that went way beyond cancer story. This repopulated the gut and it’s a sterile product. There are no bacteria in Restore, there’s only the communication network of the bacteria. What that means is that, when you get that communication network up and running, you’re grabbing bacteria from all over your ecosystem to repopulate very quickly. The exciting thing is, the longer you’re on Restore, the more bacteria you have, the more biome you have, the more Restore your gut makes. So we see this as a really nice positive feedback loop. That over time, you’re going to get more and more of this stuff being produced in your own intestines.

Jeffrey Smith: We’ll take that up in a moment, after two years of use. But I wanted to say, it’s so interesting because I hear so many advanced scientists talk about it’s the terrain that will determine bacteria. If you have an infection, people think, “Oh, kill the bacteria.” No, no, create the terrain that’s different and it will either attract or repeal the bacterial infection. What this is, it’s basically a secret to the terrain argument or maybe a verification of the terrain argument. You see that? Would you agree?

Dr. Zach Bush: The terrain is spot on. What we’re seeing with Restore and these redox molecule communication networks, that you’re allowing the bacteria to really get a foothold. In contrast to that situation where you have overgrowth of candida or klebsiella or pseudomonas, in those situations of bacteria not only have unfair advantages in their growth patterns for these caustic environments of chemicals and antibiotics and bacterial instability. They also put out stuff to prevent other bacteria from getting a foothold. What Restore does is really knock back those advantages and allow for the biome to start to reestablish some biodiversity. It’s a really exciting yin yang balancing effect that starts to happen.

It turns out most of the bacteria that you are exposed to and can repopulate in your gut and sinuses and all these membranes that need the bacteria, is breathed. It’s not eaten, it’s actually through the breath. That’s an exciting concept. In our clinic, we have our patients travel to as many different ecosystems as they can over a short period of time to repopulate their gut. Cancer patient, et cetera. Get them to the beach, get them to a waterfall, get them out to the desert. Get them up into the Appalachian Trial. Get them exposed to as many different ecosystems as you can as quickly as possible once they’re on the Restore communication network.

Jeffrey Smith: Zach, I never heard that. I’ve never heard about them getting in from the breath. It’s really interesting. What I have heard is that eating fermented vegetables provides a more diverse and more power packed amount of bacteria, positive bacteria for the gut. Do you recommend that and how would that relate to Restore?

Dr. Zach Bush: Perfect. It turns out that fermentation of vegetables is done by breathing. You’re letting the vegetable literally breathe the air around it and that’s the bacteria that should be setting up a wild ferment to make sauerkraut. You’re really getting, every breath should be giving you the same, if not even more diverse bacteria than you would get enough within a sauerkraut or a fermented food. Unfortunately, with most of the vegetables that are fermented on the market now, you go to the grocery store and buy sauerkraut, that was actually made with a probiotic. It was not a wild fermentation allowing lots of species from the air from thousands of different lactobacilli to set up shop and make a ferment. Instead, they add a few strains of lactobacilli, maybe just one, maybe three and maybe 20, whatever it is, but ultimately it’s a probiotic approach to fermentation. You’re not getting that diffuse biodiversity that you would be through the air. I think that even if you’re eating fermented foods, you’re going to have to think about your source. There are companies that are doing wild ferments, you just want to make sure your product is coming from one of those or you’re fermenting it yourself. It is so cheap to make fermented vegetables and it is so easy. We should all go back to doing that. Huge, important tool.

Jeffrey Smith: Beautiful. I think we’ve been on quite a journey here. I’m excited about some of the information that’s come out. Is there anything else you’d like to add?

Dr. Zach Bush: I think that’s a beautiful journey that we’ve painted here and I think it’s the journey of my last six years of life. The discovery that bacterial biome is critical. That bacterial biome is critical because it makes communication network. Communication network is critical because it helps support tight junction systems, therefore puts up the front line of defense in the body, not just with the gut, but also the blood brain barrier.

It’s helping a whole host of people with just enormous spectrum of inflammatory disorder. Certainly our autistic kids, which is one of the topics we wanted to hit on a lot today, is definitely the bellwether of the system. We launched with our autistic community at AutismOne last year and it’s just been an amazing thing. We’ve been working with Thinking Moms’ Revolution, 40,000 families with autistic kids. Just a fantastic experience to see these kids respond to a bacterial communication network and how fast it happens and how dramatic the neurologic changes are. Just one dramatic story after another after another. The anecdotes that are coming out from that community are showing the rapidity of which the body can heal and I think that’s the good news we needed on the tail end of a lot of bad news, is that, you know what, we have really, really screwed up our environment. We have really, really made some poor choices as consumers and as big chemical companies and everything else to create the environment we have today. The amazing, good news is man, we are some healing machines and if you start to fuel them up, it is unbelievable what they can do and how fast they can do it.

Ultimately, it is a good message that I think we can take forward from here. I think it’s a good news experience that we’ve had today, just been a joy to be a doctor with such a powerful tool in my toolbox now. It just has really changed the playing field. We’ve got to make quick changes and the good news is, nature’s got those solutions for us.

Jeffrey Smith: Zach, thank you, that’s really inspiring. I’d love to actually look at some of those testimonials, in fact, I think I probably receive more testimonials of successes when people switch to non-GMO and organic food than anyone else in the world. It’s interesting that we have a lot of experience in autistic children switching to organic and then getting better in many ways, some cases going off the spectrum altogether.

Jeffrey Smith: In fact, we highlight two of those kids in a film that I’m working on right now called Secret Ingredients. People can see the trailer on it at secretingredientsmovie.com. I wanted to emphasize to those listening this … and you can please back me up on this. This is not a substitute for bad eating, like, just go ahead and eat what you want and then take Restore. My strong suggestion is switch to 100% organic and if you can’t get organic, at least get non-GMO. The thing is, the reason why we say 100% organic is, RoundUp is sprayed, not just on RoundUp-ready crops, but it’s sprayed on wheat, barley, rye, rice, lentils, sweat potatoes, potatoes, kiwi, grapes, sugar cane, a number of things. In fact, 160 or more crops have been approved for high concentrations or high residue levels of glyphosate because it’s used as this ripening agent just before harvest. Three to five days before they harvest wheat and they spray it with glyphosate-based herbicides, which we then consume because it definitely ends up in the plant.

There’s things that glyphosate does that Restore may not be able to touch. It blocks the shikimate pathway, the P450 cytochrome pathway, it’s an endocrine disruptor, it’s linked to birth defects, it’s a mitochondrial toxin. Some of those, we haven’t gotten into the mechanisms of how it does and whether Restore might be able to touch some of those things, maybe it can, maybe it can’t, but it’s certainly worth avoiding it in the diet if you can, knowing that you’re still going to get exposed in some cases through the air and the water, et cetera.

I strongly recommend that the first line of defense is change your diet, and then if you’re interested in getting Restore and trying it and seeing if it works, I’m going to give some suggestions. First of all, use the IRT, that’s the Institute for Responsible Technology, the IRT code and you get 20% off. Then you’ll see the date to which that will be on the screen. You’ll see how long that 20% off will last and then there will be a 5% off thereafter, after that date.

Now, in addition to you getting a percentage off, the Institute for Responsible Technology joyously receives a percentage of your sale, so we end up having some income which is great for the Institute for Responsible Technology. We deserve it and we need it. So yes, please note that adding IRT not only saves you money but provides IRT some money.

Then, also, we have a Facebook page which we’ve created for your feedback. We want you to let us know and let the other people who take Restore know what your experience is. Does it have an impact on your symptoms, does it not have an impact? Is it creating side effects, is it not creating side effects? Whatever your experience, please share because this is new for us at IRT to be introducing how to heal from the impacts of GMO’s and RoundUp. It still remains above our pay grade, but we feel like we’ve done enough due diligence and had enough recommendations to bring in Zach and Restore and we have others coming up in the future that we feel would be worth sharing with you so that you can make your informed opinion and decide whether it’s something you want to add to your health regimen or not. Zach, I’ve asked you to back me up on the diet thing. Please do.

Dr. Zach Bush: That is an easy one for me to back you up on. We preach this all day long in my clinic, for multiple reasons. Number one, from a health standpoint, the tight junction effect, all this is critical stuff that glyphosate does, but the layers of injury go far beyond that now. We started the conversation talking about chelation. Chelating critical minerals and stuff like this. The reasons to go organic are thousands and so by no means do we expect Restore to be a supplant to that healthy organic diet at all. We think it’s critical that all of our consumers are not only doing that for their own health, but perhaps most importantly, we have got to change the farming industry. The only way we’re going to do that is by voting with our wallets. The more organic food we’re eating, the more organic we’re investing in, the more the farmers are going to change, the more legislation is going to change, et cetera, et cetera. I will sing that song all day long. Critical, critical for all of us to get on the band wagon and get that organic movement really revved up.

Jeffrey Smith: Great. It was perfect. Thank you. Thank you for the interview and now we can open it up to questions and comments from the audience.

About the Author

About the Author: David Roberts holds a Masters in public health from the Johns Hopkins School of Public Health with more than 20 years of experience working in quantitative research and has done public health work on three continents. He sees poor gut health as a leading public health crisis of our day and proper nutrition as the solution.
He currently serves as Chief Public Health Officer for Biomic Sciences. More from this author.

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