Reference Values

Day(s) and Time(s) Performed

Monday, Wednesday; 2 p.m.

Test Classification

This test was developed and its performance characteristics
determined by Mayo Clinic in a manner consistent with CLIA
requirements. This test has not been cleared or approved by the
U.S. Food and Drug Administration.

CPT Code Information

83519

LOINC Code Information

Test ID

Test Order Name

Order LOINC Value

HPP

Pancreatic Polypeptide, P

2721-9

Result ID

Test Result Name

Result LOINC Value

8014

Pancreatic Polypeptide, P

2721-9

Clinical Information

Pancreatic polypeptide (PP) is secreted by the pancreas in
response to hypoglycemia, ingestion of food, or "sham" feeding
(food is chewed, but not swallowed), secondary to vagal nerve
stimulation. Secretion is blocked by vagotomy or atropine.

The exact physiologic role of PP is undetermined, although the
hormone is thought to be involved in exocrine pancreatic secretion
and gallbladder emptying.

Markedly elevated levels are often associated with endocrine
tumors of the pancreas (eg, insulinoma, glucagonoma, PPoma:
pancreatic polypeptide-secreting tumor of the pancreas) Patients
with diabetes may also have elevated PP levels.