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Blackstone Labs Orthobolic is a complex of the most effective active substances focused on reducing joint pain. The supplement does not only relieves pain but also promotes the regeneration of tissues forming joints and reduces inflammation.

Joint pain is a common problem of physically active people. On one hand, resistance training supports the development of bones and increases their density. On the other hand, it is associated with the risk of damages to articular tissues. Practically, all elements forming diathrodial joints are exposed to strain and microdamages. Most of them contributes to reconstructing and strengthening tissues. However, the lack of the body’s regenerative capacity leads to the development of inflammation. This causes pain and next workouts contribute to developing and aggravating an injury.

Most supplements and medicines ease pain connected with damages to periarticular tissues, but they do not affect the root of these problems. The supplement by Blackstone Labs has been designed not only to reduce pain in joints but also stimulate physiological regeneration processes and reduce inflammation. It contains only following active substances with scientifically proven efficacy:

Palmitoylethanolamide (PAE) – this compound shows strong properties reducing pain, caused both by injuries and chronic diseases, and inflammation. Its action is based on two mechanims vital to functions of body cells. The first one involves the ability of palmitoylethanolamide to alter the activity of peroxisome proliferator-activated receptors. They regulate the expression of genes responsible for the process of inflammation, suppressing its reactions. What is more, PAE has an impact on the endocannabinoid system by stimulating cannabinoid receptors GPR55 and GPR119. As a result, it modulates neurosignalling by demonstrating a strong analgesic effect which is comparable with the one produced by the popular anandamide.

Cissus Quadrangularis – a plant with strong anti-inflammatory and analgesic properties which refers especially to articular tissues. In terms of efficacy, it is compared to non-steroid anti-inflammatory drugs, but it has no side effects. Its action is based on the ability to inhibit many mechanisms promoting inflammation and nociception. The most important one consists in blocking the metabolism of arachidonic acid, which is a substrate for cyclooxygenases COX-1 and COX-2. Both of them are enzymes stimulating the development of inflammation. Apart from that, cissus quadrangularis shows the ability to inhibit the synthesis of osteoclasts whose task in the body is to reduce bone cells. Consequently, the plant boosts bone density which has a positive impact on mechanical resistance and post-injury recovery.

Boswellia Serrata – a plant which produces resin with exceptional properties, known as olibanum. It is mentioned several times in the Bible and is used for producing natural incense. It is used in the Eastern medicine as a medicine for different aliments of the locomotor system. It enhances the immune response, stimulates regeneration processes and promotes the reconstruction of connective tissue. It has also an analgesic effect and provides effective support for the treatment of rheumatic diseases.

Curcumin – a popular food colouring which shows a beneficial impact on the body’s regeneration processes. Owing to the ability to inhibit the synthesis of NF-kB protein, it has immunomodulatory properties, strengthens the immune response and shortens the duration of inflammation. It is especially effective for the treatment of rheumatoid arthritis. Studies report also a reduction in symptoms of arthritis due to curcumin supplementation. Furthermore, it exhibits an antibacterial and antiviral effect, is a strong antioxidant and has anticancer properties. Due to its problematic bioavailability, it is found in the supplement in combination with piperine. It has been demonstrated that it improves significantly curcumin absorption.

UC-II (UNDENATURED TYPE II COLLAGEN) – a patented formula of non-processed collagen derived from chicken sternum cartilage. It demonstrates the highest bioavailability in the human body. It contains constitutent amino acids typical of collagen, hereby providing the building block for endogenous synthesis of this protein. It is a key component of connective tissues and its deficiencies contributes to increasing susceptibility to injuries and functional disorders of the locomotor system, including limited mobility of joints. Collagen supplementation has a positive effect not only on building blocks of the skeletal system but also influences mechanical resistance of muscles and skin quality.

To sum up, Blackstone Labs Orthobolic is an advanced formula which is a remedy for joint-related problems. The product should be taken both by sufferers of painful ailments of the osteoarticular system and all hard training athletes. The supplement will help enhance the endurance of bones and soft tissues, reducing the risk of injuries. It can also increase mobility, which may be a biochemical factor in limiting normal motor patterns in many training individuals.

Blackstone Labs Orthobolic is a complex of the most effective active substances focused on reducing joint pain. The supplement does not only relieves pain but also promotes the regeneration of tissues forming joints and reduces inflammation.

Joint pain is a common problem of physically active people. On one hand, resistance training supports the development of bones and increases their density. On the other hand, it is associated with the risk of damages to articular tissues. Practically, all elements forming diathrodial joints are exposed to strain and microdamages. Most of them contributes to reconstructing and strengthening tissues. However, the lack of the body’s regenerative capacity leads to the development of inflammation. This causes pain and next workouts contribute to developing and aggravating an injury.

Most supplements and medicines ease pain connected with damages to periarticular tissues, but they do not affect the root of these problems. The supplement by Blackstone Labs has been designed not only to reduce pain in joints but also stimulate physiological regeneration processes and reduce inflammation. It contains only following active substances with scientifically proven efficacy:

Palmitoylethanolamide (PAE) – this compound shows strong properties reducing pain, caused both by injuries and chronic diseases, and inflammation. Its action is based on two mechanims vital to functions of body cells. The first one involves the ability of palmitoylethanolamide to alter the activity of peroxisome proliferator-activated receptors. They regulate the expression of genes responsible for the process of inflammation, suppressing its reactions. What is more, PAE has an impact on the endocannabinoid system by stimulating cannabinoid receptors GPR55 and GPR119. As a result, it modulates neurosignalling by demonstrating a strong analgesic effect which is comparable with the one produced by the popular anandamide.

Cissus Quadrangularis – a plant with strong anti-inflammatory and analgesic properties which refers especially to articular tissues. In terms of efficacy, it is compared to non-steroid anti-inflammatory drugs, but it has no side effects. Its action is based on the ability to inhibit many mechanisms promoting inflammation and nociception. The most important one consists in blocking the metabolism of arachidonic acid, which is a substrate for cyclooxygenases COX-1 and COX-2. Both of them are enzymes stimulating the development of inflammation. Apart from that, cissus quadrangularis shows the ability to inhibit the synthesis of osteoclasts whose task in the body is to reduce bone cells. Consequently, the plant boosts bone density which has a positive impact on mechanical resistance and post-injury recovery.

Boswellia Serrata – a plant which produces resin with exceptional properties, known as olibanum. It is mentioned several times in the Bible and is used for producing natural incense. It is used in the Eastern medicine as a medicine for different aliments of the locomotor system. It enhances the immune response, stimulates regeneration processes and promotes the reconstruction of connective tissue. It has also an analgesic effect and provides effective support for the treatment of rheumatic diseases.

Curcumin – a popular food colouring which shows a beneficial impact on the body’s regeneration processes. Owing to the ability to inhibit the synthesis of NF-kB protein, it has immunomodulatory properties, strengthens the immune response and shortens the duration of inflammation. It is especially effective for the treatment of rheumatoid arthritis. Studies report also a reduction in symptoms of arthritis due to curcumin supplementation. Furthermore, it exhibits an antibacterial and antiviral effect, is a strong antioxidant and has anticancer properties. Due to its problematic bioavailability, it is found in the supplement in combination with piperine. It has been demonstrated that it improves significantly curcumin absorption.

UC-II (UNDENATURED TYPE II COLLAGEN) – a patented formula of non-processed collagen derived from chicken sternum cartilage. It demonstrates the highest bioavailability in the human body. It contains constitutent amino acids typical of collagen, hereby providing the building block for endogenous synthesis of this protein. It is a key component of connective tissues and its deficiencies contributes to increasing susceptibility to injuries and functional disorders of the locomotor system, including limited mobility of joints. Collagen supplementation has a positive effect not only on building blocks of the skeletal system but also influences mechanical resistance of muscles and skin quality.

To sum up, Blackstone Labs Orthobolic is an advanced formula which is a remedy for joint-related problems. The product should be taken both by sufferers of painful ailments of the osteoarticular system and all hard training athletes. The supplement will help enhance the endurance of bones and soft tissues, reducing the risk of injuries. It can also increase mobility, which may be a biochemical factor in limiting normal motor patterns in many training individuals.

Directions for use

Dosage

Take 2 capsules of Orthobolic once per day with a glass of water.

RECOMMENDATIONS OF MUSCLE-ZONE EXPERTJakub kola

The supplement should be used as a preventive measure, especially during strength training. It is characterised frequently by maximum intensity when it is practically impossible to do exercises perfectly. The preparation will strengthen supporting structures of joints, reducing the risk of strain injuries caused by the lack of technique.

Manufacturer

Blackstone Labs is an American manufacturer of dietary supplements and apparel for athletes and amateurs running strength sports. Its offer consists of a wide range of products with a proven formula that is highly appreciated by customers, both men and women.

Cissus quadrangularis

Information

Cissus quadrangularis (Asthisamharaka) - a plant originating from India, a relative of vines. Used in ancient medicine as an anti-inflammatory medicament and bringing the regeneration of bone tissue, it is currently recommended in cases of osteoporosis as well as supporting the bones after sports injuries. It contains a number of active substances (including triterpenoids, alpha-sitosterol). Inhibits the activity of cortisol and affects the development of muscle tissue.

Boswellia serrata

Information

Boswellia serrata extract, shows efficacy in the treatment of degenerative arthritis (particularly the knee), rheumatoid arthritis, colitis and Crohn's disease. There are ongoing attempts to use boswellic acid for the treatment of cancer. The sports supplementation uses it in the prophylaxis and the treatment of injury and inflammation occurring in the overloads of joints and during rehabilitation. Mainly used together with agents intended to assist the functioning of the organs of motion (e.g. Glucosamine, ascorbic acid, collagen, etc.).
Dosage: after consulting medical 50-200 mg per day (the amount depends on the standardized extract).

Sodium

Information

Sodium is an important component of the intracellular fluids, and is a regulator of acid-base balance. Along with potassium affects the proper of growth and provides the proper functioning of muscles and nerves. The source of acquisition is table salt (NaCl) and bladderwrack, shellfish, bacon, beef, and of plant beets and carrots. People on salt-free diet should avoid, among others, spicy sauces and smoked meats and sausages.
Sodium deficiency is very rare, at heaving sweating after a long effort (e.g. in the marathon).
Excess sodium increases blood pressure (especially for the elderly), edema and increased thirst. Exceeding the daily dose of 14g a day can cause poisoning.

Collagen

Information

Collagen is a major component that builds connective tissue (tendons, ligaments cartilage, bone, and blood vessels) from the group of fibrous proteins (i.e. scleroprotein), representing a quarter of the content of protein in the body. It is composed of amino acids (glycine, hydroxylysine, hydroxyproline and proline). Distinguished are eight types of collagen located in different parts of the human body. The source of the acquisition is gelatin (a component of the connective tissue of animal origin). It occurs most frequently in the form of processed collagen hydrolyzate characterized by a high and a good absorbency of amino acids. Recommended in sports supplementation and physically active people, as well as during convalescence after injuries and certain diseases. Available as mono-preparation supplement or of multi-compound supplement (usually also containing chondroitin, hyaluronic acid, and ascorbic acid).
Dosage: 10-20 g per day.

Bioperine

Information

Bioperine - a black pepper extract, which is a source of plant alkaloid – piperine, enhancing secretion of digestive juices, affecting the increase of the availability of food (and other chemicals) and regulating the digestive tract. Through the access to food and chemicals, it indirectly influences the development of muscle tissue and increases the exercise capacity (psychophysical). There has been a positive effect on the immune system and the intensification of the lipolysis processes observed. Available in the form of mono-preparations and as a component of supplements and nutrients.
Dosage: 5-10 mg per day.