SYNTHESIS OF CONGENERS AND PRODRUGS
NIH GUIDE, Volume 23, Number 4, January 28, 1994
RFP AVAILABLE: NCI-CM-47012-20
P.T.
Keywords:
National Cancer Institute
The Drug Synthesis and Chemistry Branch (DS&CB) of the Developmental
Therapeutics Program (DTP), Division of Cancer Treatment (DCT),
National Cancer Institute (NCI) is seeking contractors with expertise
in chemical synthesis and drug design to synthesize a variety of
compounds for evaluation as potential anti-AIDS or anti-cancer
agents. The assigned objectives of this project are to design and
synthesize the following: (a) congeners of lead compounds having
confirmed activity to enhance activity or potency; (b) prodrugs with
structural modifications that may provide altered pharmacokinetics,
altered drug transport, improved bio-availability through increased
water solubility, or increased chemical stability; (c) other altered
structures that possess elements of both congeners and prodrugs; and
(d) compounds related to natural products, e.g., alkaloids,
heterocycles, nucleosides, and peptides.
Each contractor should have available a fully operational facility,
including all necessary equipment and instrumentation for all aspects
of the contract. The nature of this project requires that the
following restriction be applied: "The NCI signs legally binding
agreements with certain suppliers (often pharmaceutical or chemical
companies) that state that all information on compounds submitted by
the supplier will be held confidential. The successful offeror will
be expected to synthetically modify such commercially confidential
(discreet) materials. Thus, pharmaceutical or chemical companies
could obtain valuable data on new lead compounds. Therefore, in
order to honor the confidentiality agreement with the original
supplier, the NCI believes that the compounds cannot be sent to
potential competitors of the supplier, and thus pharmaceutical and
chemical companies must be excluded from the competition." For
purposes of this restriction, a pharmaceutical or chemical company is
defined as an organization that sells drugs and chemicals to the
general public for profit. The Standard Industrial Classification
(SIC) number is 8731. This is a recompetition of contracts currently
held by the Georgia Tech Research Corporation (Georgia Institute of
Technology), Purdue Research Foundation, and the University of
Tennessee. It is anticipated that two cost-reimbursement contracts
will be awarded for a period of two years beginning on or about
September 30, 1994.
INQUIRIES
Request for Proposals (RFP) No. NCI-CM-47012-20 will be issued on or
about January 31, 1994 and proposals will be due approximately 30
days thereafter. Copies of the RFP may be obtained by sending a
written request to:
Charles Lerner
Research Contracts Branch, TCS
National Cancer Institute
Executive Plaza South, Room 603
Bethesda, MD 20892
Telephone: (301) 496-8603
.