Colon cancer: Colorectal cancer is common . The Mediterranean/Eastern population is less susceptible to
it. However, colorectal cancer affects younger people in our population. We believe
this is a reflection of a genetic susceptibility, which overwhelms
the environmental causes such as alcohol consumption, diet etc. Our population is thus suited to
identify the possible genetic
cause.

We offer a high fidelity microsatellite instability tests based on
allelotyping and immunohistochemistry algorithms.

MLH1-MSH2-PMS2
Sequencing

We offer
exome and whole genome sequencing on colorectal cancers and saliva/blood
DNA to identify somatic and germline mutations respectively.

We perform immunohistochemitry for MLH1, MSH2, PMS2 and MSH6

Our
lab performs mlh1 and msh2 sequencing as part of the European
Molecular Genetics quality assurance program

We perform Ki-Ras mutation profiling on CRC to tailor therapy.
Patients with Wild-type Ki-Ras are more suited for chemical intervention