When the FBI takes on a case of disappearing college girls, Jack Crawford recruits Will Graham, a gifted criminal profiler with a unique view into the psyche of serial killers, to consult. Jack also seeks the help of Dr. Hannibal Lecter, a brilliant psychiatrist, who, unbeknownst to him, is not only one of the most successful serial killers of all time, but also a cannibal. After a copycat strikes, Will and Hannibal join forces to track down the culprit.