Green Chemistry approach is need of the hour in the field of chemistry. Considering the damage to environment, all Pharmaceutical and chemical industry develop interest in new synthetic processes using green chemistry. Most of the drugs are designed, developed and synthesized using various approaches of green chemistry. Microwave assisted synthesis, sonochemistry, solvent free reactions, reuse of catalyst are various approaches of green chemistry used in drug and chemical synthesis. These approaches will be promising in obtaining drug with good yield, less toxic to environment and cost effective.