The list comprehension notation we saw in Section
More Expressions
is more general, and applies to anything which has an implementation of both
Monad
and
Alternative
:

In general, a comprehension takes the form
[
exp
|
qual1,
qual2,
…,
qualn
]
where
quali
can be one of:

To translate a comprehension
[exp
|
qual1,
qual2,
…,
qualn]
, first any qualifier
qual
which is a
guard
is translated to
guard
qual
, using the following function:

Then the comprehension is converted to
do
notation:

Using monad comprehensions, an alternative definition for
m_add
would be:

While
do
notation gives an alternative meaning to sequencing, idioms give an alternative meaning to
application
. The notation and larger example in this section is inspired by Conor McBride and Ross Paterson’s paper “Applicative Programming with Effects”
[1]
.

First, let us revisit
m_add
above. All it is really doing is applying an operator to two values extracted from
Maybe
Int
. We could abstract out the application:

Using this, we can write an alternative
m_add
which uses this alternative notion of function application, with explicit calls to
m_app
:

Rather than having to insert
m_app
everywhere there is an application, we can use idiom brackets to do the job for us. To do this, we can give
Maybe
an implementation of
Applicative
as follows, where
<*>
is defined in the same way as
m_app
above (this is defined in the Idris library):

Using
<*>
we can use this implementation as follows, where a function application
[|
f
a1
…an
|]
is translated into
pure
f
<*>
a1
<*>
…
<*>
an
:

Idiom notation is commonly useful when defining evaluators. McBride and Paterson describe such an evaluator
[1]
, for a language similar to the following:

Non-commissioned members rise from the lowest ranks in most nations. Education standards for non-commissioned members are typically lower than for officers (with the exception of specialised military and highly-technical trades; such as aircraft, weapons or electronics engineers). Enlisted members only receive leadership training after they are
promoted
to positions of responsibility, or as a prerequisite for such. In the past (and in some countries today but to a lesser extent), non-commissioned members were almost exclusively
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, whereas officers were volunteers.

A non-commissioned officer (NCO) is an
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member of the armed forces holding a position of some degree of authority who has (usually) obtained it by advancement from within the non-commissioned ranks. Officers who are
non-commissioned
usually receive management and leadership training, but their function is to serve as supervisors within their area of trade specialty. Senior NCOs serve as advisers and leaders from the duty section level to the highest levels of the armed forces establishment, while lower NCO grades are not yet considered management specialists. The duties of an NCO can vary greatly in scope, so that an NCO in one country may hold almost no authority, while others such as the United States and the United Kingdom consider their NCOs to be "the backbone of the military" due to carrying out the orders of those officers appointed over them.
[11]

In most maritime forces (navies and coast guards), the NCO ranks are called
petty officers
while enlisted ranks prior to attaining NCO/petty officer status typically known as seaman, or some derivation thereof. In most traditional infantry, marine and air forces, the NCO ranks are known as
sergeants
and
corporals
, with non-NCO enlisted ranks referred to as privates and airmen.

However, some countries use the term
commission
to describe the promotion of enlisted soldiers. Especially in countries with mandatory service in the armed forces. These countries refer to their NCOs as professional soldiers, rather than as officers.

Subsection “Blocking apical constriction does not arrest SG invagination”, last paragraph. The authors state that "the significant 'wiggliness' of the AJs suggests a decrease of cortical tension." I think this is unlikely-in cultured mammalian cells, we and others have found that decreasing cortical tension (e.g., by Rok or myosin inhibition) leads to smoothly rounded cell borders – really wiggly cell borders are likely to reflect actin filaments oriented perpendicular to the membrane.

Subsection “Blocking apical constriction does not arrest SG invagination”. When during the process of convergent elongation of the organ primordium does Fog expression go off?

The only set of data I found was weak was the attempt to rescue Fog by SG specific Fog re-expression. Given the likelihood that levels and timing were not precisely replicated, I think the speculation about non-autonomous functions was not well supported and I would suggest removing this data.

Discussion. The authors mention a number of times the incredibly provocative fact that they may have identified a GPCR related to Mist expressed in the SG. This would be very interesting, but the degree of discussion of this unpublished data in the manuscript seemed unwarranted unless they wanted to add this data.

Subsection “Additional morphogenetic processes take place during SG invagination”, last paragraph. The authors should add the data showing that the tissue level circumferential myosin cable does form in
fog
mutants – this is a key part of their model. More generally, I think a more careful description of the progression of junctional myosin in wildtype and mutants would be beneficial – it appeared, for example, that it was AP planar polarized before the process began.

The final circuitry diagram in
Figure 7L
is nice but would be better if supplemented with a diagram showing the cell shape changes themselves and how the authors think apical constriction and tissue level constriction work together.

Reviewer #2:

The manuscript describes the cell biology behind the invagination of salivary gland primordia in the
Drosophila
embryo. The changes in cell morphology that occur during this process has been published previously, but the present paper incorporates new features (e. g., the pulsatile apical medial myosin networks) that allow comparison to other well characterized morphogenetic movements in
Drosophila
, especially the ventral furrow and posterior midgut. In many respects (e. g., the involvement of RoK and Folded gastrulation) the SC pathway shows a regulation of apical constriction and myosin activity very similar to these other processes.

An AD FS server provides federated authentication between Office 365 and the accounts in the corp.contoso.com domain hosted on DC1.

To create an Azure virtual machine for ADFS1, fill in the name of your subscription and the resource group and Azure location for your Base Configuration, and then run these commands at the Azure PowerShell command prompt on your local computer.

Tip

Click for a text file that contains all the PowerShell commands in this article.

To check name resolution and network communication between ADFS1 and DC1, run the
ping dc1.corp.contoso.com
command and verify that there are four replies.

ping dc1.corp.contoso.com

Next, join the ADFS1 virtual machine to the CORP domain with these commands at the Windows PowerShell prompt on ADFS1.

Figure 3: Adding the AD FS server

Figure 3 shows the addition of the ADFS1 server to the DirSync for Office 365 dev/test environment.

PROXY1 provides proxying of authentication messages between users attempting to authenticate and ADFS1.

To create an Azure virtual machine for PROXY1, fill in the name of your resource group and Azure location, and then run these commands at the Azure PowerShell command prompt on your local computer.

Note

PROXY1 is assigned a static public IP address because you will create a public DNS record that points to it and it must not change when you restart the PROXY1 virtual machine.

Next, add a rule to the network security group for the CorpNet subnet to allow unsolicited inbound traffic from the Internet to PROXY1's private IP address and TCP port 443. Run these commands at the Azure PowerShell command prompt on your local computer.