A 35-year-old man presents with a febrile illness after travel in West Africa, and severe malaria is diagnosed. Treatment with artesunate is recommended. Artesunate is a member of a class of antimalarial agents called artemisinins, and it is at leas
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Ezetimibe lowers low-density lipoprotein cholesterol, but no studies have documented a clinical benefit from the drug. Nevertheless, this study shows the growing use of ezetimibe in the United States, to a much greater extent than in Canada, where d
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DEHAL1, the gene encoding iodotyrosine deiodinase in the thyroid, allows for the reuse of iodide for thyroid hormone synthesis. The authors identified four patients from three unrelated families with three unique mutations; all had a dramatic reduct
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Erythrocytes from patients with pyruvate kinase deficiency are resistant to invasion by Plasmodium falciparum. Such erythrocytes that succumb to infection are more rapidly cleared by macrophages than are infected erythrocytes from control subjects.
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A multicenter trial evaluated patients with previous anterior-wall myocardial infarction who were not candidates for an implantable cardioverter-defibrillator. Patients were randomly assigned either to have an automated external defibrillator (AED)
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A cohort of patients who underwent stent implantation for unprotected left main coronary artery disease was compared with a propensity-matched cohort of patients who underwent coronary-artery bypass grafting. The risk of death and the composite outc
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Trachoma, a chronic bacterial keratoconjunctivitis, has always been inextricably linked with poverty. It would not even be mentioned in the curricula of many U.S. medical schools today if not for ...
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