Structure based drug designFor decades researchers have attempted to gain a better understanding of the processes between and on the outside of cells. An important step into the understanding of these processes was the discovery of the 3D structure of the acetylcholine binding protein (AChBP), which functions as a gateway for substances from outside a cell to the inside or vice versa. Knowledge of this structure has opened a world of possibilities for its use as a target for drug discovery.

This project aims to develop substances that can influence the AChBP. So far researchers have been able to influence nicotine receptors in the brain which is important for the cognitive functioning of the brain. They now also aim for receptors that play an important role in the communication in the brain, and e.g. are involved in dementia and Alzheimer's disease, as well as in the signalling in addiction processes. The next step is the development of pharmaceuticals that can modulate specific receptors. This will at least lead to a decrease in side effects of certain drugs, but maybe in the future it may eventually even lead to drugs that cure addictions.