They compared 2312 Icelandic men who underwent medical or surgical management for BPH (including treatment with 5a-reductase inhibitors, which are known to lower the PSA concentration) vs 33 779 presumed-healthy Icelandic men.

Because of the ability of 5a-reductase inhibitors to inhibit the conversion of testosterone to DHT, finasteride may cause abnormalities of the external genitalia of a male fetus of a pregnant woman who receives finasteride.

The changes described above are expected pharmacological effects of drugs belonging to the class of 5a-reductase inhibitors and are similar to those reported in male infants with a genetic deficiency of 5a-reductase.

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