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THE demand is simple&colon; companies should publish all data from clinical trials, whatever the results, so the safety and efficacy of drugs can be evaluated on the basis of all available evidence.

But persuading companies is proving trickier. Last week, the American Medical Association called on the US government to establish a registry for all clinical trials in the country. And to force companies to register trials, the International Committee of Medical Journal Editors wants all journals to refuse to publish any results from trials that were not registered at the outset.