Re: Here's a bunch of stuff all about Adrafinil

> Does anyone know about Adrafinil and what it is suppose to be good for? > > Thank you- > KL

ADRAFINIL (Olmifon)

Rapidly restores vigilance and alertness in older people and the physically and mentally tired. Has a powerful antidepressant action far superior to that of fluoxetine (Prozac) and clomipramine (Anafranil) and is without any serious side effects. Adrafinil restores your powers of concentration, memory and intellectual function. When administered to older people who have lost interest in life, adrafinil makes them want to take part in life again and they find that they have renewed energy and vigor. Adrafinil may be correctly described as an anti-aging drug because it directly combats degeneration in the part of the brain that allows you to take pleasure in life. Elderly people very often have disturbed sleep patterns and take many naps during the day. Adrafinil restores a youthful sleep/wake cycle of full alertness in the daytime and deep restorative sleep at night. After several weeks of treatment with Adrafinil daytime sleepiness disappears, interest in intellectual activity is restored and depression lifts. It is very important to note that this improved quality of alertness is NOT accompanied with mental excitation and insomnia as occurs with amphetamine or caffeine. The correct dosage is 300 to 600 mg per day. The dosage can be adjusted according to response. Remember it takes three weeks for all the effects of Adrafinil to become apparent. Do not use Adrafinil if you have any type of kidney or liver problem or if you suffer from epilepsy.

Adrafinil provides alertness in most without the feeling often felt with stimulants that usually are prescribed for a person withnarcolepsy. Such as amphetamines etc. Also the possibility of tolerance is low with its continued use. There is however aneed for certain Liver function tests on a regular basis with its continued use. Normally the same types of required testing as with the medication " cylert " which iscommonly prescribed in the USA. It is also used in certain parts europe as a "antidepressant". It is the combination ofAdrafinil's releasing stimulantive arousal effect(s), and its antidepressant effects that some doctors in europe recommendAdrafinil over its newer form of Modafinil. There have been studies done in the United States "measuring depression inindividuals with sleep disorders",. In one study it was suggested that the "rate of narcolepsy and depression is estimated to be between 30-52%".

ADRAFINIL

Adrafinil: Alertness Without Stimulation

Adrafinil is the prototype of a new class of smart drug - the eugeroics (ie, "good arousal") - designed to promote vigilanceand alertness. Developed by the French pharmaceutical company Lafon Laboratories, adrafinil (brand name, Olmifon) hasbeen approved in many European countries for treating narcolepsy, a condition characterized by excessive daytime sleepinessand other unusual symptoms.

Non-narcoleptic users generally find that adrafinil gives them increased energy and reduces fatigue, while improving cognitivefunction, mental focus, concentration, and memory. It has been reported that quiet people who take adrafinil become moretalkative, reserved people become more open, and passive people become more active.

Of course, many stimulant drugs, ranging from caffeine to methamphetamine, are known to produce similar alerting/energizingeffects. Adrafinil has been described by some users as a "kinder, gentler" stimulant, because it provides these benefits butusually with much less of the anxiety, agitation, insomnia, associated with conventional stimulants.

Adrafinil's effects are more subtle than those of the stimulants you may be used to, building over a period of days to months.They appear to be based on its ability to selectively stimulate 1-adrenergic receptors in the brain.2 These receptors normallyrespond to norepinephrine (noradrenaline), a neurotransmitter linked to alertness, learning, and memory. This is in contrast toconventional stimulants, which stimulate a broader spectrum of brain receptors, including those involving dopamine. Its morefocused activity profile may account for adrafinil's relative lack of adverse side effects.

Dosing

The standard dose is 2 to 4 300-mg tablets per day for improving cognitive function, although some people may find lowerdoses produce a desirable degree of improvement. Higher doses have been used to treat narcolepsy.

ADRAFINIL (OLMIFON) A unique substance which improves daytime alertness and vigilance without altering the phases of sleep. Take 2 to 4 tablets per day. After 8 to 10 days of treatment feelings of fatigue disappear, after 15 days there is a powerful effect on activity and after 1 to 3 months cognitive effects are experienced. Intellectual function is improved particularly, the ability to formulate new ideas and recall information. Avoid if you suffer from epilepsy, kidney or liver impairment.

I remember Serzone brought on depression and dumbing, despite the fact it wasincreasing serotonin and NE. Based on above info on Adrafinil, stimulating alpha 1sis good for altertness, intelligence, and mood. Serzone does the opposite as it antagonizesalpha1. I wonder if Adrafanil would be a good antidote with Serzone? I wonder whichwould compete the strongest?

Personal Comments: As with all meds, the listed side effects can look scary. In real life, I have found Adrafinil to have far fewer (if any) side effects compared to just about anything else on the market. The liver thing is also a concern to some people. I have been on Adrafinil for a long time, have had three blood liver tests in that time, and each test came back perfectly normal. John