The aim of the present study was to investigate psychological damage aspects, including the Internalizing and externalizing problems based on the dimensions of behavioral activation system (BAS) and behavioral inhibition system (BIS). For this purpose, first, 270 persons of high school adolescent students (including boys and girls) of arak's schools were selected through a multistage cluster sampling. Then Brain / behavioral Systems questionnaire were distributed among them to be answered. After initial data analysis, 64 of them, based on final score distribution (Z Standard) in Brain / behavioral Systems questionnaire were chosen. Finally, in order to test the hypothesis of this study, participants were have studied to measure Internalizing and externalizing problems, Through Brain / behavioral, Multiple anxiety, depression, aggression and hyperactivity questionnaires. The collected data were analyzed using a Multivariate analysis of variance, ANOVA and post hoc tests. Results showed that are significant difference between the four personality groups in Internalizing and externalizing problems. So that, High sensitivity of behavioral inhibition system (HBIS) and Low sensitivity of behavioral inhibition system (LBIS) group, had the highest anger and aggression had the highest anger and aggression (p<0/05). In symptoms of of social anxiety and physical symptoms of anxiety, high sensitivity Behavioral Activation System (HBAS), showed a significant difference with other groups (p<0/05). The results showed that the more active and less active of brain/ behavioral systems can make adolescents vulnerable to psychological damages. The results showed that high and low levels of brain-behavioral systems sensitivity, leading to psychological disorders.