A seriously injured Sayid Jarrah was brought to the Temple by his friends Hugo Reyes, Jack Shephard, Kate Austen, Jin Kwon, Miles Straume, and James Ford, to be healed under the orders of Jacob. The Others attempted to heal Sayid but it didn't work and he died. However, Sayid came back to life, to everyone's shock. Dogen later told Jack that Sayid now had a darkness growing inside of him, which turned out to be true as Sayid joined ranks with The Man in Black and murdered Dogen and his translator Lennon. The Man in Black then entered the Temple in his smoke form and murdered all of the Others who were still there. ("LA X, Part 2")("Sundown")

With the freighter anchored, Minkowski and fellow crew member Brandon decided to tour the Island and set out aboard the ship's tender. Before reaching the Island, Brandon started "acting crazy", forcing Minkowski to return to the freighter. Brandon subsequently died. Minkowski too began to suffer the effects of time-transported consciousness and later he died as well. Martin Keamy brought a seriously injured Mayhew back to the ship where he later died after being severely beaten by The Man in Black in his smoke form. When pilot Frank Lapidus refused to fly the blood hungry Keamy back to the Island he killed Ray and Captain Gault; Frank was forced to fly them anyway. Keamy later constructed a bomb on the ship and created a dead man's trigger so that, if his heart stopped beating, the bomb would blow up the entire ship. He did, in fact, die at the hands of Ben Linus, and the ship exploded, killing Michael, Hendricks, Jeff and three un-named 815 survivors. The only survivors were the Oceanic Six, Frank Lapidus and Desmond Hume who escaped the ship by helicopter and Jin Kwon who was picked up by Danielle Rousseau's science team in the 80's. ("The Constant")("Something Nice Back Home")("Cabin Fever")("There's No Place Like Home, Part 2")

When the Black Rock shipwrecked on the Island, there were only 5 officers and Jonas Whitfield left on board (discluding the slaves). Whitfield then killed all the slaves in fear of them killing him if he were to release them, but before he could kill Richard Alpert the remaining officers on deck were murdered by The Man in Black in his smoke form, which then killed Whitfield. In 2004, Leslie Arzt was killed when a dynamite stick he was holding exploded. Anthony Cooper was brought there by his son John Locke and was murdered by James Ford as he was the real Sawyer who had caused his parents' deaths. ("Ab Aeterno")("Exodus, Part 2")("The Brig")

Jacob was murdered by Ben Linus under The Man in Black's orders. When Ilana's team and Jacob's bodyguards (including Bram) entered the temple and discovered Jacob had been killed, they tried to attack the Man in Black, who turned into his smoke form and murdered all four of them. ("The Incident, Part 2")("LA X, Part 1")

Charlie and Desmond Hume both entered the Looking Glass Station to switch off the machine, which was blocking all communication from the Island with the outside world, in order for Naomi Dorrit to get in touch with the people on her boat. Mikhail later entered under Ben Linus' orders, which included killing them all. Mikhail shot and killed both Greta and Bonnie, but Desmond managed to stab Mikhail, and they thought he was dead. Mikhail however, fled and swam to the outside of the hatch and up to the porthole of the room Charlie was in; he detonated a grenade, killing himself and smashing the window permitting water to enter the hatch. Charlie sealed the door shut in order to save Desmond's life, accepting his own fate and dying. ("Through the Looking Glass, Part 2")

Nikki and Paulo were both bitten by a medusa spider which paralyzed them. Sawyer and Hurley thought that the pair were deceased, and began to bury them in the graveyard - just as Nikki opened her eyes. But it went unnoticed, and they were both buried alive. ("Exposé")

Boone was brought to the caves by John Locke in order to recieve medical treatment from Jack Shephard, after he was seriously injured when the beachcraft he was exploring fell from a cliff. Jack fought to save Boone's life along with Sun Kwon and Michael Dawson, but Boone knew he was dying and told Jack to let him go. ("Do No Harm")

In September 2004, Desmond Hume followed his Swan station partner Kelvin to the Cove. Here, he discovered he was going to leave the Island and leave Desmond alone in the hatch. Desmond was furious that Kelvin had lied, and attacked him. He accidentally smashed Kelvin's head against a rock, killing him. ("Live Together, Die Alone, Part 2")

Claire Littleton captured Justin and brought him back to her tent, threatening to kill him if he didn't tell her where her son Aaron Littleton" was. Jin Kwon told Claire that Kate Austen had taken Aaron when Claire vanished three years before, and raised him off the Island. Claire killed Justin anyway, by impaling him in the chest with an axe. ("Lighthouse")

Nathan, a tail section survivor, was wrongly accused of being a spy for the Others by Ana Lucia Cortez; she trapped him in a hole she had dug up, and threatened to cut off his fingers should he not tell her the truth. The real spy Goodwin Stanhope knew that Ana Lucia would soon realise Nathan was innocent, and snapped Nathan's neck, dragging his body away to give a false impression that Nathan had been released by the Others and escaped. It backfired, and Ana Lucia figured out who Goodwin really was. She stabbed him in the chest with a stake. ("The Other 48 Days")