When you approach a member of the opposite sex to ask them out and they respond with a pitying smile.

Robert confidently approached the blonde at the bar and offered to buy her a drink. She briefly turned to him, gave a pitying smile, then turned away as if nothing had happened. Robert, visibly deflated, slunk back to his friends. One turned to him sympathetically and said, 'Smilezoned again?' A dejected Robert nodded pathetically, then wept into his cheap off-brand vodka and cola.