Inflammation in Tuberculosis: Interactions, Imbalances and Interventions
Proinflammatory cytokines, including interferons, tumor necrosis factor and interleukin 1 along with microRNAs and eicosanoids form an interactive network during tuberculosis. Cross-regulation between proinflammatory mediators strongly impacts on infected cell death patterns. These processes, in concert with local concentrations of proteases, such as cathepsins, serpins and matrix-metalloproteinases, affect tissue integrity, shape the architecture of granulomas and modulate tissue repair. [Curr Opin Immunol] AbstractRestrictions to HIV-1 Replication in Resting CD4+ T Lymphocytes
The authors summarize their current molecular and pathophysiological understanding of the multi-faceted interactions of HIV-1 with resting CD4+ T lymphocytes. [Cell Res] Full Article

Innate Immune Detection of Microbial Nucleic Acids
Recent developments in pattern recognition receptors research have uncovered important new molecular details as to how Toll-like receptors and retinoic acid-inducible gene-I-like receptors distinguish pathogen from self RNA, while the discovery of cytosolic DNA sensing pathways for interferon induction has revealed completely new innate signaling mechanisms, and also questions how innate immunity discriminates between self and non-self DNA, if at all. [Trends Microbiol] AbstractVisit our reviews page to see a complete list of reviews in the infectious disease research field.