This paper describes a joint research effort which took place between the Shanghai Bureau of Environmental Protection, Tsinghua University (Beijing), and the University of Michigan. The specific problem focus for applying the techniques of systems analysis has been to the issue of water pollution control for the Huangpu River in Shanghai, China. Four systems analysis methodologies were utilized: water quality modeling; Cost minimization of wastewater treatment; Cost-benefit analysis; and Multiattribute decision analysis. Study results are discussed.