Activated on April 4, 2005, the Texas City VA Outpatient Clinic is one of two Michael E. DeBakey VA Medical Center satellite clinics located in Galveston County. In September 2008, the clinic was severely damaged by Hurricane Ike.

On March 18, 2011, the Michael E. DeBakey VA Medical Center held a special Ribbon Cutting Ceremony officially re-opening the Texas City VA Outpatient Clinic. The approximately 10,000 sq. ft. clinic is located at 9300 Emmett F. Lowry Expressway, Suite 206 next to the Mall of the Mainland. It is in the Mainland Crossing Shopping Center next to Sam’s Club, the University of Texas Medical Branch Family Healthcare Center, and other retail establishments.