HPV Chemical List History

Note: EPA no longer updates this information, but it may be useful as a reference or resource

October 9, 1998

The U.S. high production volume (HPV) chemicals are those which are manufactured
in or imported into the United States in amounts equal to or greater than
one million pounds per year. The U.S. HPV chemicals were identified through
information collected under the Toxic Substances Control Act (TSCA) Inventory
Update Rule (IUR). Organic chemicals that are manufactured in, or imported
into, the United States in amounts equal to or exceeding 10,000 pounds
per year are subject to reporting under the TSCA IUR. Reporting is required
every four years.

The HPV Challenge Program Chemical List consists of all the HPV chemicals
reported during the 1990 IUR reporting year. Inorganic chemicals and polymers,
except in special circumstances, were not subject to the IUR reporting
requirements although a number were reported in error. The HPV Challenge
Program Chemical List contains about 2,800 chemicals.

The 1990 IUR list was selected as the starting point for this program.
As subsequent reporting years identify additional chemicals (including
inorganics, once the corresponding reporting requirements have been added
under the IUR), they will be posted here for information purposes. EPA
expects that, over time, the testing of new HPV chemicals will become
routine, and companies may wish to test new HPV chemicals as they appear.

In keeping with that eventual goal, EPA is posting the 1994 IUR List of
HPV Additions, which contains about 500 organic HPV chemicals which were
newly reported as HPV in the 1994 IUR and are thus not part of the HPV
Challenge Program at this time. This list is being provided particularly
for use by companies who desire to propose categories of chemicals for
testing and wish to include chemicals from the 1994 list in their category
definitions.

Each HPV chemical list is provided in database format. The database tables
contain one record per chemical. Each record contains three fields. The
first field (CASNO) contains the Chemical Abstract Services registry number,
which is a unique identification number assigned to a chemical. The second
field (INDICATOR) is an indicator variable that, if greater than 0, signifies
that the chemical falls outside the scope of the HPV Challenge Program.
The possible values for the indicator and their corresponding reasons
for falling outside the scope of the program are:

1
= Chemical is not considered a candidate for testing under the HPV Challenge
Program, based on preliminary EPA review indicating that testing using
the SIDS base set would not further our understanding of the chemical's
properties, or

2
= Chemical is otherwise being handled under the Organisation for Economic
Co-operation and Development (OECD) HPV Screening Information Data Set
(SIDS) Program.

Finally, the name of the chemical is found in the last field (CHEMICAL).

December
9, 1998

The scope of the HPV Challenge Program does not include testing of polymers
and inorganic chemicals. These substances were excluded from the reporting
requirements of the Inventory Update Rule (IUR) of 1986 unless regulated
by a TSCA Section 4, 5(a)(2), 5(b)(4) or 6 rule or an order under Section
5(e) or 5(f), as stipulated under 40 CFR 710.26. To maintain consistency
within the HPV Challenge Program, however, the Agency decided it would
not include any polymers or inorganics in the program. Since the HPV Challenge
Program Chemical List was derived from the 1990 IUR, it was expected that
only a minimal number of these substances would be on the list, and that,
in most cases, those inclusions would be the result of misreporting by
individual companies.

In preparing the HPV Challenge Program Chemical List, the Agency reviewed
the original 1990 IUR list of HPV chemicals for polymers and inorganics
(misreported and appropriately reported). This review utilized a computer
algorithm that, as noted by the Agency in the preamble to the 1986 IUR,
would not identify all polymers and inorganic substances on the list,
due to the highly complex nature of the CAS nomenclature rules and the
lack of a complete molecular formula for many of the Class 2 substances
on the TSCA Inventory. Because of the limitations of the screening algorithm,
some polymers and inorganic chemicals did escape the automatic search
and did appear on the first HPV Challenge Program Chemical List, which
was published on October 9, 1998.

In response to questions regarding the polymers and inorganics that appeared
on the initial HPV Challenge Program Chemical List, the Agency conducted
a comprehensive manual review of the list. A similar exercise was conducted
on the 1994 IUR List of HPV Additions. As a result of this effort, additional
polymers and inorganic substances have been identified and removed from
the scope of the HPV Challenge Program.

To avoid any potential confusion from having multiple lists of HPV Challenge
Program chemicals, the Agency is not removing these chemicals from the
original list, but rather is marking them with an indicator of "3" to
denote that these chemicals are not included in the HPV Challenge Program.
The description of this indicator reads:

3
= Chemical is not subject to the HPV Challenge Program because it is
a polymer or inorganic substance.

A few Class 2 substances and pigments, which may be polymers or inorganics,
may remain on the HPV Challenge Program Chemical List because the name and/or
definition provided by the original submitter to the TSCA Inventory lacked
conclusive information on which to determine whether the chemical was a
polymer or inorganic substance. In the absence of additional definitive
information, those substances were left on the HPV Challenge Program Chemical
List.

Although the HPV Challenge Program Chemical List was developed using Inventory
Update Rule submissions, the removal of chemicals from the scope of the
HPV Challenge Program does not necessarily mean that they are excluded from
current or future IUR reporting. All questions concerning whether a chemical
is subject to IUR reporting should be submitted to the Agency as described
in the IUR Instruction Manual (http://www.epa.gov/opptintr/iur98).

In this column, "F" and "P" refer specifically to the commitment of a company
or consortium to sponsor a particular chemical. The "F" or "P" shows whether
the company or consortium has provided all or only part of the required
elements for a commitment to the Program. This differs from the "F" and
"P" found in the Chemical Sponsorship Status column.

Chemical Sponsorship Status Column

The "F" and "P" found in the Chemical Sponsorship column refer to the status
of a chemical in the HPV Challenge Program. A chemical is fully sponsored
if the Agency has received at least one full commitment from a company or
consortium. A chemical is provisionally sponsored if the Agency has received
at least one provisional commitment, but no full commitments, from a company
or consortium.

A description of what constitutes full and provisional commitments and fully
and provisionally sponsored chemicals can be found in the section on "How
to Use the Lists."

Both the Chemical Sponsorship Status and the Sponsor Commitment Status columns
will be updated weekly as commitments are received by the Agency. In addition,
a link to the actual letters submitted or received by sponsors will be added
at a later date. The Sponsor Commitment Status column is not yet searchable,
and data from that column will not appear in searches performed using the
other indicators available on the list. The Agency is currently modifying
the search function to allow searches using data in this column, and when
that search capability becomes available, the Agency will provide notification
on the "What's New" page.

The Agency recognizes that some chemicals are sponsored by more than one
company or consortium. In these cases, the Agency suggests that the companies
or consortia coordinate sponsorship of the particular chemical to avoid
duplication of effort and ensure costs are minimized. When multiple companies
or consortia submit commitments covering the same chemical, the Agency contacts
all of the sponsors to alert them to the duplication and to encourage coordination
of effort.

SIDS Chemicals

The Agency has updated the HPV Challenge Program Chemical List and the 1994
List of HPV Additions to add an indicator of "2" to thirteen chemicals.
The "2" indicator denotes chemicals that are otherwise being handled under
the OECD HPV SIDS Program. Eight of these 13 chemicals were selected in
the latest phase of the OECD HPV SIDS chemical selection process. The chemicals
were nominated by sponsor countries at the SIDS Initial Assessment Meeting
held in Paris, France June 29-30, July 1, 1999. The remaining five chemicals
(74-87-3, 111-41-1, 135-19-3, 4461-52-3, and 20324-32-7) are also in the
SIDS Program and were nominated at other times. Twelve of the 13 chemicals
are on the HPV Challenge Program Chemical List. The remaining chemical is
on the 1994 List of HPV Additions. The thirteen chemicals, listed by CAS
number, are:

74-87-3

111-41-1

839-90-7

25321-09-9

80-09-1

123-11-5

1330-20-7

94-36-0

135-19-3

4461-52-3

98-51-1
(1994 list)

793-24-8

20324-32-7

Additionally, the indicator "2" was removed from two chemicals (25640-78-2
and 26896-20-8), as these chemicals are no longer included in the OECD HPV
SIDS program, and thus can be sponsored in the HPV Challenge Program.

The HPV Challenge Program Chemical List and the 1994 List of HPV Additions
are provided below for downloading in two forms, DBF and Portable Data Format
(PDF). While the content of the lists in DBF and PDF format are the same,
the DBF versions include more records than the PDF versions. With the PDF
versions, the CAS number is listed only once for all companies and consortia
that are sponsoring that chemical. With the DBF versions, the CAS number
is repeated for each sponsor. Repeating the information allows users to
sort the file by something other than CAS number. A key to the various values
used in the lists can be found on the "How to Use
the Lists" page.

November 5, 1999

The Agency has updated both the HPV Challenge Program Chemical List and
the 1994 List of HPV Additions to reflect responses received through the
close of business on October 29, 1999.

November 10, 1999

The Agency has updated both the HPV Challenge Program Chemical List and
the 1994 List of HPV Additions to reflect responses received through the
close of business on November 5, 1999. Additionally, an indicator of "2"
was added to CAS No. 77-92-9 indicating that this chemical is otherwise
being handled under the Organization for Economic Co-operation and Development
(OECD) HPV Screening Information Data Set (SIDS) Program. An indicator of
"3" was added to CAS No. 11097-59-9 indicating that this chemical is not
subject to the HPV Challenge Program because it is a polymer or inorganic
substance.

November 17, 1999

The Agency has updated both the HPV Challenge Program Chemical List and
the 1994 List of HPV Additions to reflect responses received through the
close of business on November 12, 1999.

November 30, 1999

The Agency has updated both the HPV Challenge Program Chemical List and
the 1994 List of HPV Additions to reflect responses received through the
close of business on November 26, 1999. If you have any questions concerning
these lists, please submit them using the comment button located at the
bottom of this page.

March 7, 2000

The Agency has updated both the HPV Challenge Program Chemical List and
the 1994 List of HPV Additions to reflect responses received through the
close of business on March 3, 2000. This update captures all commitments
received by the close of the voluntary sign-up period on December 1, 1999.

An indicator of "2" was added to CAS Nos. 95-50-1, 106-42-3, 624-41-9, and
25376-45-8, indicating that these chemicals are otherwise being handled
under the Organization for Economic Co-operation and Development (OECD)
HPV Screening Information Data Set (SIDS) Program.

Three new codes were added to the list during this update, two numerical
ones in the "Indicator" column and one letter code in both the "Chemical
Sponsorship Status" and the "Sponsor Commitment Status" columns. These new
codes are:

Indicator Column Values:

4
= A company or consortium has clearly indicated to and has had confirmed
by ICCA their sponsorship of this chemical in the Global HPV Initiative
of the International Council of Chemical Associations, and all information
essentially equivalent to a Full Commitment under the HPV Challenge Program
(i.e., chemical name, CAS number, start year for each chemical, technical
contact person and telephone number) has been provided to the Agency.

5
= Chemical meets the criteria for being "No Longer HPV" and is thus no
longer subject to the HPV Challenge Program. This chemical may be sponsored.

June 16, 2000

The Agency has updated both the HPV Challenge Program Chemical List and
the 1994 List of HPV Additions to reflect responses received through the
close of business on May 26, 2000. This update captures all commitments
received by the close of the voluntary sign-up period on December 1, 1999.
Letters received since December 1, 1999 reflect clarifications to previously
submitted commitments. As of today, no new commitments have been received.

An indicator of "2" was added to CAS Number 8007189 indicating that this
chemical is otherwise being handled under the Organization for Economic
Cooperation and Development (OECD) HPV Screening Information Data Set
(SIDS) Program.

Ind = 2

8007189

An indicator of "5" was added to the CAS Numbers below
indicating that these chemicals meet the criteria for being "No Longer
HPV" and are no longer subject to the HPV Challenge Program. These
chemicals may be sponsored

Ind = 5

101633

534156

619669

824782

1300738

2738069

13188608

13360639

21729986

35884663

68308678

December 15, 2000

The Agency has updated both the HPV Challenge Program Chemical List and
the 1994 List of HPV Additions to reflect letters received through the close
of business on December 1, 2000. This update captures all commitments received
by close of the voluntary sign-up period on December 1, 1999. Letters received
since December 1, 1999 generally reflect clarifications to previously submitted
commitments.

The International Council of Chemical Associations (ICCA) HPV commitments
have also been updated at this time

Indicator Column Values:

0
= Chemical is a candidate for sponsorship under the HPV Challenge Program

1
= Chemical is not considered a candidate for testing under the HPV Challenge
Program, based on preliminary EPA review indicating that testing using
the SIDS base set would not further our understanding of the chemical's
properties

2
= Chemical is otherwise being handled under the Organization for Economic
Co-operation and Development (OECD) HPV Screening Information Data Set
(SIDS) Program

3
= Chemical is not subject to the HPV Challenge Program because it is a
polymer or inorganic substance.

4
= A company or consortium has had confirmed by the International Council
of Chemical Associations (ICCA) their sponsorship of this chemical in
the HPV Initiative of ICCA, and all information essentially equivalent
to a Full Commitment under the HPV Challenge Program (i.e., chemical name,
CAS number, start year for each chemical, technical contact person and
telephone) has been provided to the Agency.

5
= Chemical meets the criteria for being "No Longer HPV" and is thus no
longer subject to the HPV Challenge Program. This chemical may be sponsored,
however.

An
indicator of "1" was added to the CAS Numbers below indicating that these
chemicals are not considered candidates for testing under the HPV Challenge
Program, based on preliminary EPA review indicating that testing using the
SIDS base set would not further our understanding of the chemical's properties.
These chemicals may be sponsored, however.

Ind = 1

142472 65996636 65996647

An
indicator of "2" was added to the CAS Numbers below indicating that these
chemicals are otherwise being handled under the Organization for Economic
Cooperation and Development (OECD) HPV Screening Information Data Set (SIDS)
Program.

Ind = 2

78795

95498

96311

96333

97632

97869

99990

100549

103764

106638

106887

106989

107153

108316

108996

109068

110861

110985

111900

112072

112152

112254

112572

122521

122996

123546

124174

140318

140885

141106

141322

143226

301100

513359

556821

584849

616386

683181

753731

770354

818086

993168

1461229

1461252

1559348

3290924

3590849

5102830

5131668

5567157

6358856

6881943

13048334

15625895

20324338

23783428

25498491

26471625

29911282

42978665

57583343

57583354

63449398

68515935

68784269

68815678

68855458

68909182

72275866

73758620

An
indicator of "5" was added to the CAS Numbers below indicating that these
chemicals meet the criteria for being "No Longer HPV" and are no longer
subject to the HPV Challenge Program. These chemicals may be sponsored,
however.

Ind = 5

54217

85698

89087

94746

132274

139026

554121

616217

13927770

28984896

68476482

68477225

68609643

Chemical Sponsorship Status Column Values:

I
= ICCA Confirmed Commitment

Company or consortium has clearly indicated to and has had confirmed by
ICCA their sponsorship of a chemical(s) in the HPV Initiative of the International
Council of Chemical Associations.

All confirmed Company and Consortium ICCA commitments are identified in
a letter to EPA's Administrator from ICCA dated August 4, 2000. This letter
supercedes the earlier ICCA letter dated February 25, 2000.

Companies can meet the requirements of the HPV Challenge Program either
directly through the Challenge Program or indirectly through the OECD HPV
SIDS Program and/or the ICCA HPV Initiative. U.S. companies deciding to
sponsor chemicals under the HPV Challenge Program can also identify those
chemicals as U.S. contributions to the OECD HPV SIDS Program and/or the
ICCA HPV Initiative. Such chemicals may have both an "I" (confirmed ICCA
sponsorship) and an "F" (Full sponsorship or fully sponsored HPV Challenge
Program Commitment) in the Sponsor Commitment Status field.

It is noted that a chemical with confirmed sponsorship under the ICCA HPV
Initiative may not be listed with a "4" in the indicator column. All data
elements necessary for Full Commitment status under the HPV Challenge Program
(i.e., chemical name, CAS number, start year for each chemical, technical
contact person and telephone number) must also be provided to the Agency
in order for the chemical to be designated as an ICCA sponsored chemical
under the HPV Challenge Program (and thus receive a "4" in the indicator
column.

October 12, 2001

The Agency has updated both the HPV Challenge Program Chemical List and
the 1994 List of HPV Additions to reflect letters received through the close
of business on July 13, 2001. This update generally reflects clarifications
or changes to previously submitted commitments.

These updated lists also reflect changes to the
following Indicator Column Values:

Indicator = 1

An
indicator of "1" was added to the CAS Numbers below indicating that these
chemicals are not considered candidates for testing under the HPV Challenge
Program, based on preliminary EPA review indicating that testing using the
SIDS base set would not further our understanding of the chemical's properties.
These chemicals may be sponsored, however.

59029 68334281 68918423 68989980

Indicator = 2

An
indicator of "2" was added to the CAS Numbers below indicating that these
chemicals are otherwise being handled under the Organization for Economic
Cooperation and Development (OECD) HPV Screening Information Data Set (SIDS)
Program.

HPV Challenge Program Chemical List:

50000

105602

124403

7659861

64742489

56815

105646

128370

8032324

64742490

58082

106310

134203

8052413

64742810

65850

107415

137326

13674878

64742821

68111

107926

139333

13952846

64742887

68122

107960

139899

15708415

64742898

71410

108112

140012

16111629

64742945

74895

108189

142825

16470249

64742956

75014

108214

142847

16485475

64771728

75047

108394

142905

18328900

66455172

75310

108678

287923

18719034

67762258

75387

108918

528449

20824560

67762270

75503

109524

532321

21265509

67762305

75649

109604

538932

22473785

67762418

75683

109739

540841

25103097

67859512

77474

109831

544763

25155253

68333802

78637

109897

552307

25264931

68390567

78784

110054

582252

25339564

68410968

78922

110190

598561

25377837

68410979

78966

110543

614459

25550145

68476506

79094

110623

629505

25584832

68477316

79312

110918

629629

26523784

68516187

79345

111273

629732

26748414

68527059

79947

111659

629969

27215958

68551166

80159

111842

661198

29964849

68551177

80433

111864

818611

30618849

68551199

88733

111875

822060

32360057

68551202

88744

111922

927071

36653824

68603156

90722

112301

1222055

38051104

68603178

95658

112403

1321944

45294186

68911615

96059

112425

1338234

61788452

70024929

96184

112709

1704627

61788463

70693060

97723

112721

1761713

63393828

70955112

97858

112889

2050922

64741635

75782864

98942

112903

2495274

64741657

75782875

100378

116530

2549533

64741737

90622461

100516

121448

2935902

64741840

93924073

102067

121915

3006824

64741851

129813678

102829

123057

3033623

64741919

103093

123626

5332730

64742069

104756

123966

5421465

64742467

105599

124301

7534943

64742478

1994 List of HPV Additions:

58559

107835

1939362

3425614

19910657

107711

1717006

2495252

6140745

25378227

Additionally, the indicator "2" was removed from the
following chemical, as this chemical is no longer included in the OECD HPV
SIDS program, and thus can be sponsored in the HPV Challenge Program:

4461523

Indicator = 4

No
new Indicator "4"s have been added to the list. All confirmed Company and
Consortium International Council of Chemical Associations (ICCA) commitments
are identified in a letter to EPA's Administrator from ICCA dated August
4, 2000. This letter supercedes the earlier ICCA letter dated February 25,
2000.

Indicator = 5

An
indicator of "5" was added to the CAS Numbers below indicating that these
chemicals meet the criteria for being "No Longer HPV" and are no longer
subject to the HPV Challenge Program. These chemicals may be sponsored,
however.

62544

107562

118296

141526

141980

693210

1497683

2738069

4356609

6423434

13393936

13889924

17564646

18169578

25037450

32131172

36876138

39464705

52836314

55701058

61790350

68308678

68443856

73467773

The following Values were added to the Sponsor Commitment Status Column:

V = Viable Commitment. Same as Full Commitment but the commitment
to sponsor the particular chemical was received after the December 26, 2000
proposed test rule was published (65
FR 81658). In addition to meeting the standard requirements of the HPV
Challenge Program, sponsors must also provide full copies of studies for
viable chemicals.

Q = Provisional Viable Commitment. Same as Provisional Commitment
(all the required commitment information was not provided.) but the commitment
to sponsor a particular chemical was received after the December 26, 2000
proposed test rule was published (65
FR 81658). Provisional viable commitments will be upgraded to Viable
status (see above) upon receipt and processing of required commitment information.

V = Viable-Sponsored Chemical. The Agency has received at least one
viable commitment from a company or consortium to sponsor the particular
chemical.

Q = Provisional Viable-Sponsored Chemical. Company/Consortia has
provided most, but not all, of the Viable Commitment information. The Agency
has received at least one provisional viable commitment, but not viable
commitments, from a company or consortium to sponsor the particular chemical.

A = Test Rule Chemical. Chemicals listed in the proposed "Testing
of Certain High Production Volume Chemicals; Data Collection and Development
on High Production Volume (HPV) Chemicals" rule (65
FR 81658). These chemicals may be sponsored prior to publishing a final
rule. Note that sponsorship after the December 26, 2000 date (a viable commitment)
requires that, in addition to meeting the standard requirements of the HPV
Challenge Program, sponsors also provide full copies of studies.

C = Voluntary
Children's Chemical Evaluation Program Chemical. Chemicals listed
in the Voluntary Children's Chemical Evaluation Program notice (64
FR 81699). These chemicals may be sponsored. Note that sponsorship after
the December 26, 2000 date (a viable commitment) requires that, in addition
to meeting the standard requirements of the HPV Challenge Program, sponsors
also provide full copies of studies.

March 13, 2002

In some cases, companies or consortia have sponsored chemicals that are
not on either the HPV Challenge Program Chemical List or the 1994 List of
HPV Additions. A list of these chemicals, called "Additional Chemicals Sponsored
Under the HPV Challenge Program" is being added with this update. The Agency
has updated both the HPV Challenge Program Chemical List and the 1994 List
of HPV Additions to reflect letters received through the close of business
on January 18, 2002. This update generally reflects clarifications or changes
to previously submitted commitments.

These updated lists also reflect changes to the
following Indicator Column Values:

Indicator = 1

No
new indicators of "1" were added to the list. A "1" indicates that the chemical
is not considered a candidate for testing under the HPV Challenge Program,
based on preliminary EPA review indicating that testing using the SIDS base
set would not further our understanding of the chemical's properties. A
chemical with an indicator of "1" may be sponsored, however.

Indicator = 2

An
indicator of "2" was added to the CAS Numbers below indicating that these
chemicals are otherwise being handled under the Organization for Economic
Cooperation and Development (OECD) HPV Screening Information Data Set (SIDS)
Program.

CAS Number

CAS Number

CAS Number

CAS Number

CAS Number

75763

75945

78104

80104

98135

107186

107460

108463

108985

115219

124709

131179

527071

540976

541026

541059

675627

872504

919302

919313

999973

1066359

1067534

1185553

1310583

1310732

1313139

1322981

1760243

2487903

2530838

2530872

2550063

4253343

4518983

7351613

7447407

7647010

7778543

7782505

10025782

10026047

10043524

11099062

12125029

13528886

17689779

22984549

27636755

85117506

Additionally, the indicator "2" was removed from the following chemical2,
as these chemicals are no longer included in the OECD HPV SIDS program,
and thus can be sponsored in the HPV Challenge Program:

95658 20324327

Indicator = 4

Based
on the January 31, 2002 letter from ICCA, new Indicator "4"s have been added
to the list. All confirmed Company and Consortium International Council
of Chemical Associations (ICCA) commitments are identified in letters to
EPA's Administrator from ICCA dated August 4, 2000 and January 31, 2002.
These letters supercede the earlier ICCA letter dated February 25, 2000.

Indicator = 5

No
new indicator "5"s were added to the lists. A "5" indicates that the chemical
meets the criteria for being "No Longer HPV" and is no longer subject to
the HPV Challenge Program. A chemical with an indicator of "5" may be sponsored,
however.

May 22, 2002

The Agency has updated the HPV Challenge Program Chemical List, the 1994
List of HPV Additions and the Additional Chemicals Sponsored under the HPV
Challenge Program to reflect letters received through the close of business
on March, 15, 2002. This update generally reflects clarifications or changes
to previously submitted commitments.

August 8, 2002

The Agency has updated the HPV Challenge Program Chemical List, the 1994 List of HPV Additions and the Additional Chemicals Sponsored under the HPV Challenge Program to reflect letters received through the close of business on July 12, 2002. This update generally reflects clarifications or changes to previously submitted commitments.

These updated lists also reflect changes to the following Indicator Column Values:

Indicator = 1

No new indicators of "1" were added to the list. A "1" indicates that the chemical is not considered a candidate for testing under the HPV Challenge Program, based on preliminary EPA review indicating that testing using the SIDS base set would not further our understanding of the chemical's properties. A chemical with an indicator of "1" may be sponsored, however.

Indicator = 2

No
new incator "2" were added to the list. A "2" indicates
that these chemicals are otherwise being handled under the Organization
for Economic Cooperation and Development (OECD) HPV Screening Information
Data Set (SIDS) Program.

Indicator = 4

No new indicator
"4" was added to the list. All confirmed International Council
of Chemical Associations (ICCA) commitments are identified in documents
to EPA's Administrator from ICCA dated August 4, 2000, January 31, 2002
and April 12, 2002. These letters supercede the earlier ICCA letter dated
February 25, 2000.

Indicator = 2,4

An Indicator "2,4" was added to the CAS numbers below. A "2" indicates that
these chemicals are otherwise being handled under the Organizational for
Economic Cooperation and Development (OECD) HPV Screening Information Data
Set (SIDS) Program and a indicator "4" indicates that these chemicals are
confirmed International Council of Chemical Associations (ICCA) commitments
identified in documents to EPA's Administrator from ICCA dated August 4,
2000, January 31, 2002 and April 12, 2002. These letters supercede the earlier
ICCA letter dated February 25, 2000.

Chemicals receiving new Ind=2, 4 flags

75127

3323533

78591

4454051

87569

6104309

100005

288324

106445

1312761

115071

1490046

115866

6834920

120809

7775146

603350

7791255

947046

10213793

1319773

13517243

1328536

85422920

2855132

86089170

Indicator = 5

No new indicator
"5"s were added to the lists. A "5" indicates that the
chemical meets the criteria for being "No Longer HPV" and is no
longer subject to the HPV Challenge Program. A chemical with an indicator
of "5" may be sponsored, however.

An indicator of "2" was removed from the following chemicals as they are no longer included in the OECD SIDS Program.

75070 75150 75218 110270 72275866

Indicator = 3 (Polymer or Inorganic)

A chemical that is not subject to the HPV Challenge Program because it is a polymer or inorganic substance has been assigned an indicator of "3." This chemical may be sponsored, however.

No new indicators of "3" were added to the list.

Indicator = 4 (ICCA)

Chemicals sponsored under the International Council of Chemical Associations (ICCA) HPV Initiative, confirmed by ICCA and having all information essentially equivalent to a Full Commitment under the HPV Challenge Program (i.e., chemical name, CAS number, start year for each chemical, technical contact person and telephone number) provided to the Agency have been assigned an indicator of "4."

Based on the August 26, 2002 letter from ICCA, new indicators of "4" have been added to the list. Also based on this letter, indicators of "4" have been removed from some chemicals. All confirmed company and consortia ICCA commitments are identified in letters to EPA's Administrator from ICCA dated August 4, 2000, January 31, 2002, April 12, 2002, and August 26, 2002.

Indicator = 5 (No Longer HPV)

A chemical that meets the criteria for being "No Longer HPV" and is no longer subject to the HPV Challenge Program has been assigned an indicator of "5." This chemical may be sponsored, however.

An indicator of "2" was removed from the following chemical as it is no longer included in the OECD SIDS Program.

27193868

Indicator = 3 (Polymer or Inorganic)

A chemical that is not subject to the HPV Challenge Program because it is a polymer or inorganic substance has been assigned an indicator of "3." This chemical may be sponsored, however.

No new indicators of "3" were added to the list.

Indicator = 4 (ICCA)

Chemicals sponsored under the International Council of Chemical Associations (ICCA) HPV Initiative, confirmed by ICCA and having all information essentially equivalent to a Full Commitment under the HPV Challenge Program (i.e., chemical name, CAS number, start year for each chemical, technical contact person and telephone number) provided to the Agency have been assigned an indicator of "4." All confirmed company and consortia ICCA commitments are identified in letters to EPA's Administrator from ICCA dated August 4, 2000, January 31, 2002, April 12, 2002, and August 26, 2002.

No new indicators of "4" were added to the list.
Indicator = 5 (No Longer HPV)

A chemical that meets the criteria for being "No Longer HPV" and is no longer subject to the HPV Challenge Program has been assigned an indicator of "5." This chemical may be sponsored, however.

A chemical that is not subject to the HPV Challenge Program because it is a polymer or inorganic substance has been assigned an indicator of "3." This chemical may be sponsored, however.

No new indicators of "3" were added to the list.

Indicator = 4 (ICCA)

Chemicals sponsored under the International Council of Chemical Associations (ICCA) HPV Initiative, confirmed by ICCA and having all information essentially equivalent to a Full Commitment under the HPV Challenge Program (i.e., chemical name, CAS number, start year for each chemical, technical contact person and telephone number) provided to the Agency have been assigned an indicator of "4."

Based on the March 28, 2003 from ICCA, new indicators of "4" have been added to the list. All confirmed company and consortia ICCA commitments are identified in letters to EPA's Administrator from ICCA dated August 4, 2000, January 31, 2002, April 12, 2002, August 26, 2002, and March 28, 2003.

Indicator = 5 (No Longer HPV)

A chemical that meets the criteria for being "No Longer HPV" and is no longer subject to the HPV Challenge Program has been assigned an indicator of "5." This chemical may be sponsored, however.

An indicator of "5" was added to the CAS numbers below.

825-90-1

1572-52-7

61791-47-7

27288-44-4

September 3, 2003

In order to standardize the chemical names of the HPV Challenge Program chemical lists, with this update, EPA is changing the chemical names to reflect the Chemical Abstracts (CA) 9th Collective Index (9CI) names. Ninth Collective Index names are those used for the TSCA Inventory. Changes have been made to the following lists only: the HPV Challenge Program Chemical List, the 1994 List of HPV Additions, the Additional Chemicals Sponsored Under the HPV Challenge Program, and the Sponsored Chemicals List. Please note that chemical name changes are not highlighted on these lists. Chemical names on the HPV Challenge Summary Report have not been changed. Additional changes to chemical names will occur with future website updates as the Agency continues to review and modify its lists to reflect the appropriate chemical names.

A chemical that is not subject to the HPV Challenge Program because it is a polymer or inorganic substance has been assigned an indicator of "3." This chemical may be sponsored, however.

No new indicators of "3" were added to the list.

Indicator = 4 (ICCA)

Chemicals sponsored under the International Council of Chemical Associations (ICCA) HPV Initiative, confirmed by ICCA and having all information essentially equivalent to a Full Commitment under the HPV Challenge Program (i.e., chemical name, CAS number, start year for each chemical, technical contact person and telephone number) provided to the Agency have been assigned an indicator of "4."

Based on the July 14, 2003 letter from ICCA, new indicators of "4" have been added to the list. Also based on this letter, indicators of "4" have been removed from some chemicals. All confirmed company and consortia ICCA commitments are identified in letters to EPA's Administrator from ICCA dated August 4, 2000, January 31, 2002, April 12, 2002, August 26, 2002, March 28, 2003, and July 14, 2003.

Indicator = 5 (No Longer HPV)

A chemical that meets the criteria for being "No Longer HPV" and is no longer subject to the HPV Challenge Program has been assigned an indicator of "5." This chemical may be sponsored, however.

No new indicators of "5" were added.

October 14, 2003

In order to standardize the chemical names of the HPV Challenge Program chemical lists, with this update, EPA is changing the chemical names to reflect the Chemical Abstracts (CA) 9th Collective Index (9CI) names. Ninth Collective Index names are those used for the TSCA Inventory. Changes have been made to the following lists only: the HPV Challenge Program Chemical List, the 1994 List of HPV Additions, the Additional Chemicals Sponsored Under the HPV Challenge Program, and the Sponsored Chemicals List. Please note that chemical name changes are not highlighted on these lists. Chemical names on the HPV Challenge Summary Report have not been changed. Additional changes to chemical names will occur with future website updates as the Agency continues to review and modify its lists to reflect the appropriate chemical names.

A chemical that is not subject to the HPV Challenge Program because it is a polymer or inorganic substance has been assigned an indicator of "3." This chemical may be sponsored, however.

No new indicators of "3" were added to the list.

Indicator = 4 (ICCA)

Chemicals sponsored under the International Council of Chemical Associations (ICCA) HPV Initiative, confirmed by ICCA and having all information essentially equivalent to a Full Commitment under the HPV Challenge Program (i.e., chemical name, CAS number, start year for each chemical, technical contact person and telephone number) provided to the Agency have been assigned an indicator of "4."

Based on the July 14, 2003 letter from ICCA, new indicators of "4" have been added to the list. Also based on this letter, indicators of "4" have been removed from some chemicals. All confirmed company and consortia ICCA commitments are identified in letters to EPA's Administrator from ICCA dated August 4, 2000, January 31, 2002, April 12, 2002, August 26, 2002, March 28, 2003, and July 14, 2003.

Indicator = 5 (No Longer HPV)

A chemical that meets the criteria for being "No Longer HPV" and is no longer subject to the HPV Challenge Program has been assigned an indicator of "5." This chemical may be sponsored, however.

Please note that dashes have been added to all CAS Numbers on this website. This change ensures that all CAS Numbers conform to standard CAS format. Dashes must now be included when searching for a CAS Number.

January 22, 2003

In order to standardize the chemical names of the HPV Challenge Program chemical lists, with this update, EPA is changing the chemical names to reflect the Chemical Abstracts (CA) 9th Collective Index (9CI) names. Ninth Collective Index names are those used for the TSCA Inventory. Changes have been made to the following lists only: the HPV Challenge Program Chemical List, the 1994 List of HPV Additions, the Additional Chemicals Sponsored Under the HPV Challenge Program, and the Sponsored Chemicals List. Please note that chemical name changes are not highlighted on these lists. Chemical names on the HPV Challenge Summary Report have not been changed. Additional changes to chemical names will occur with future website updates as the Agency continues to review and modify its lists to reflect the appropriate chemical names.

An indicator of "2" was removed from the following chemicals as they are no longer included in the OECD SIDS program.

109-86-4

527-07-1

4300-97-4

Indicator = 3 (Polymer or Inorganic)

A chemical that is not subject to the HPV Challenge Program because it is a polymer or inorganic substance has been assigned an indicator of "3." This chemical may be sponsored, however.

No new indicators of "3" were added to the list.

Indicator = 4 (ICCA)

Chemicals sponsored under the International Council of Chemical Associations (ICCA) HPV Initiative, confirmed by ICCA and having all information essentially equivalent to a Full Commitment under the HPV Challenge Program (i.e., chemical name, CAS number, start year for each chemical, technical contact person and telephone number) provided to the Agency have been assigned an indicator of "4."

Based on the October 7, 2003 letter from ICCA, new indicators of "4" have been added to the list. Also based on this letter, indicators of "4" have been removed from some chemicals. All confirmed company and consortia ICCA commitments are identified in letters to EPA's Administrator from ICCA dated August 4, 2000, January 31, 2002, April 12, 2002, August 26, 2002, March 28, 2003, July 14, 2003, and October 7, 2003.

Indicator = 5 (No Longer HPV)

A chemical that meets the criteria for being "No Longer HPV" and is no longer subject to the HPV Challenge Program has been assigned an indicator of "5." This chemical may be sponsored, however.

No new indicators of "5" were added.
March 12, 2004

In order to standardize the chemical names of the HPV Challenge Program chemical lists, with this update, EPA is changing the chemical names to reflect the Chemical Abstracts (CA) 9th Collective Index (9CI) names. Ninth Collective Index names are those used for the TSCA Inventory. Changes have been made to the following lists only: the HPV Challenge Program Chemical List, the 1994 List of HPV Additions, the Additional Chemicals Sponsored Under the HPV Challenge Program, and the Sponsored Chemicals List. Please note that chemical name changes are not highlighted on these lists. Chemical names on the HPV Challenge Summary Report have not been changed. Additional changes to chemical names will occur with future website updates as the Agency continues to review and modify its lists to reflect the appropriate chemical names.

An indicator of "2" was removed from the following chemicals as they are no longer included in the OECD SIDS program.

98-56-6

121-69-7

2524-03-0

2524-04-1

Indicator = 3 (Polymer or Inorganic)

A chemical that is not subject to the HPV Challenge Program because it is a polymer or inorganic substance has been assigned an indicator of "3." This chemical may be sponsored, however.

No new indicators of "3" were added to the list.

Indicator = 4 (ICCA)

Chemicals sponsored under the International Council of Chemical Associations (ICCA) HPV Initiative, confirmed by ICCA and having all information essentially equivalent to a Full Commitment under the HPV Challenge Program (i.e., chemical name, CAS number, start year for each chemical, technical contact person and telephone number) provided to the Agency have been assigned an indicator of "4."

All confirmed company and consortia ICCA commitments are identified in letters to EPA's Administrator from ICCA dated August 4, 2000, January 31, 2002, April 12, 2002, August 26, 2002, March 28, 2003, July 14, 2003, and October 7, 2003.

No new indicators of "4" were added to the list.

Indicator = 5 (No Longer HPV)

A chemical that meets the criteria for being "No Longer HPV" and is no longer subject to the HPV Challenge Program has been assigned an indicator of "5." This chemical may be sponsored, however.

No new indicators of "5" were added.

May 28, 2004

In order to standardize the chemical names of the HPV Challenge Program chemical lists, with this update, EPA is changing the chemical names to reflect the Chemical Abstracts (CA) 9th Collective Index (9CI) names. Ninth Collective Index names are those used for the TSCA Inventory. Changes have been made to the following lists only: the HPV Challenge Program Chemical List, the 1994 List of HPV Additions, the Additional Chemicals Sponsored Under the HPV Challenge Program, and the Sponsored Chemicals List. Please note that chemical name changes are not highlighted on these lists. Chemical names on the HPV Challenge Summary Report have not been changed. Additional changes to chemical names will occur with future website updates as the Agency continues to review and modify its lists to reflect the appropriate chemical names.

An indicator of "2" was removed from the following chemicals as they are no longer included in the OECD SIDS program.

106-98-9

124-18-5

629-59-4

3039-83-6

Indicator = 3 (Polymer or Inorganic)

A chemical that is not subject to the HPV Challenge Program because it is a polymer or inorganic substance has been assigned an indicator of "3." This chemical may be sponsored, however.

No new indicators of "3" were added to the list.

Indicator = 4 (ICCA)

Chemicals sponsored under the International Council of Chemical Associations (ICCA) HPV Initiative, confirmed by ICCA and having all information essentially equivalent to a Full Commitment under the HPV Challenge Program (i.e., chemical name, CAS number, start year for each chemical, technical contact person and telephone number) provided to the Agency have been assigned an indicator of "4."

All confirmed company and consortia ICCA commitments are identified in letters to EPA's Administrator from ICCA dated August 4, 2000, January 31, 2002, April 12, 2002, August 26, 2002, March 28, 2003, July 14, 2003, October 7, 2003, and May 17, 2004.

Twenty-five new indicators of "4" were added to the list.

78-51-3

80-56-8

354-33-6

372-09-8

1333-86-4

8002-26-4

8006-64-2

8016-81-7

8050-09-7

8050-15-5

8050-26-8

8050-31-5

8052-10-6

9005-90-7

61790-12-3

61790-51-0

64365-17-9

65996-96-5

65997-03-7

65997-04-8

65997-06-0

65997-13-9

68201-59-2

68938-00-1

68955-98-6

An indicator of "4" was removed from the following chemicals as they are no longer included in the OECD SIDS program.

90-72-2

119-61-9

301-02-0

630-08-0

3048-65-5

16883-83-3

32210-23-4

34690-00-1

38051-10-4

Indicator = 5 (No Longer HPV)

A chemical that meets the criteria for being "No Longer HPV" and is no longer subject to the HPV Challenge Program has been assigned an indicator of "5." This chemical may be sponsored, however.

Two new indicators of "5" were added.

6842-15-5

27157-94-4

Indicator = 2, 4 (SIDS/ICCA)

An Indicator "2,4" was added to the CAS number below. A "2" indicates that this chermical is otherwise being handled under the Organization for Economic Cooperation and Development (OECD) HPV Screening Information Data Set (SIDS) Program and an indicator "4' indicates that this chemical is a confirmed International Council of Chemical Associations (ICCA) commitment identified in documents to EPA's Administrator from ICCA dated August 4, 2000, January 31, 2002, April 12, 2002, August 26, 2002, March 28, 2003, July 14, 2003, October 7, 2003 and May 17, 2004.