p62 is up-regulated in mouse proteinopathic hearts and promotes aggresome formation and autophagy activation and protects cardiomyocytes against proteotoxic stress

cdk1 (show CDK1 Antibodies) phosphorylates p62 in vitro and in vivo at T269 and S272, which is necessary for the maintenance of appropriate cyclin B1 (show CCNB1 Antibodies) levels and the levels of cdk1 (show CDK1 Antibodies) activity necessary to allow cells to properly enter and exit mitosis.

These data suggest that the RVFV NSs protein is able to interact with the TFIIH subunitp62 inside infected cells and promotes its degradation, which can occur directly in the nucleus.

cdk1 (show CDK1 Antibodies) phosphorylates p62 in vitro and in vivo at T269 and S272, which is necessary for the maintenance of appropriate cyclin B1 (show CCNB1 Antibodies) levels and the levels of cdk1 (show CDK1 Antibodies) activity necessary to allow cells to properly enter and exit mitosis.