A medicine bundle was a bag or blanket filled with a few, very personal items, used as a ritual aid during a vision quest by Native Americans. A medicine bundle had to be comprised of items that define a person and ground them, thus ultimately allowing them to take the journey into the self.

In 2372, Chakotay used his medicine bundle while performing the pakra, a ritual to honor the anniversary of his father's death. His medicine bundle was lost during an encounter with the Kazon-Ogla, and he was required to replicate a replacement in order to finish the ritual. (VOY: "Initiations")

After a near-death experience in 2374 that left him deeply disturbed and uncertain, Neelix assembled his own medicine bundle after seeking Chakotay's help in performing a vision quest. Neelix's bundle consisted of a necklace that belonged to his sister Alixia, a flower from Kes' garden, and a model of the Guiding Tree. (VOY: "Mortal Coil")