In the film, Jack (Sandler) was living an almost perfect life, with the exception of one, annoying constant – his twin sister Jill (also Sandler). Every year he has to tolerate a Thanksgiving visit from his smothering sister, who doesn’t take long to turn his life upside down. As the weekend intrusion starts stretching into a month, the siblings fight, tease, and bicker in the way only twins can. When it becomes clear Jill is never leaving, Jack sets into motion several schemes that he hopes will return Jill to where he loves her most – the other side of the country.

Holmes joins the cast as Erin, Jack’s wife and mother to their two children. “She’s a very busy wife and mother,” Holmes explains. “When Jill comes to town and creates a lot of mayhem within the family, she’s the one who’s trying to keep it all together.

“It was wonderful to see Adam transform into Jill,” she continues. “As a woman, it was nice to have conversations with a man about shaving legs, how pantyhose and heels feel, and all of the tougher parts about being a woman. Adam was a great sport – it was really, really fun.”

Holmes has showcased her ability as an actress to play a wide spectrum of diversified roles. She has appeared in several notable films ranging from the action blockbuster “Batman Begins,” directed by Christopher Nolan, to critically acclaimed art house pictures such as Ang Lee's “The Ice Storm” and Peter Hedges' “Pieces of April.”

Holmes was most recently seen on the big screen in “Don’t Be Afraid of The Dark” and “The Son of No One.” On television, she portrayed First Lady Jacqueline Kennedy in “The Kennedys,” opposite Greg Kinnear as President John F. Kennedy.

Holmes has worked with some of Hollywood's most prominent and talented directors. Her credits include “Wonder Boys,” directed by Curtis Hanson; “Thank You for Smoking,” directed by Jason Reitman; “The Gift,” directed by Sam Raimi; “Abandon,” directed by Stephen Gaghan; “Go,” directed by Doug Liman; “Phone Booth,” directed by Joel Schumacher; “First Daughter,” directed by Forest Whitaker; “Teaching Mrs. Tingle,” directed by Kevin Williamson; and “Disturbing Behavior,” directed by David Nutter. 2008 marked her Broadway debut in Arthur Millers “All My Sons” opposite John Lithgow, Dianne Wiest and Patrick Wilson. Her portrayal of Ann garnered glowing reviews and established her as an accomplished actress on both screen and stage.

In 1996, Holmes landed the role of Libbets Casey opposite Tobey Maguire and Sigourney Weaver in Lee's award-winning drama “The Ice Storm” while in Los Angeles for pilot season. A year later she was cast as Joey Potter on the TV series "Dawson's Creek," opposite James Van Der Beek and Michelle Williams. The show quickly became the highest-rated series on the WB network throughout its six-season run.