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This chapter begins with a discussion of the formation of the nervous system. It then describes oligodendrocyte precursors, migration of O-2A progenitors during normal development, oligodendrocyte precursors originate in a specialized region of the ventricular zone in the ventral half of the neural tube, oligodendrocyte development in the forebrain, specification of the oligodendrocyte lineage depends on signals from the ventral midline, and the embryonic origins of astrocytes.

This chapter begins with a discussion of the formation of the nervous system. It then describes oligodendrocyte precursors, migration of O-2A progenitors during normal development, oligodendrocyte precursors originate in a specialized region of the ventricular zone in the ventral half of the neural tube, oligodendrocyte development in the forebrain, specification of the oligodendrocyte lineage depends on signals from the ventral midline, and the embryonic origins of astrocytes.