..The restricted expression and/or action of the signaling components indicate that a series of intercellular interactions regulate chorioallantoic development...

Spatial and temporal expression of the 23 murine Prolactin/Placental Lactogen-related genes is not associated with their position in the locus

David G SimmonsDepartment of Comparative Biology and Experimental Medicine, The University of Calgary, Calgary, CanadaBMC Genomics 9:352. 2008

..To understand the regulation and potential functions of these genes, we conducted a detailed temporal and spatial expression study in the placenta between embryonic days 7.5 and E18.5 in three genetic strains...

Cell-cell adhesion defects in Mrj mutant trophoblast cells are associated with failure to pattern the chorion during early placental development

..Lastly, we show that Mrj(-/-) chorions at embryonic day 8.5 have expanded Rhox4b expression domains and do not form normal layers of gene expression suggesting that chorion patterning requires Mrj...

Early patterning of the chorion leads to the trilaminar trophoblast cell structure in the placental labyrinth

..These data indicate that the three differentiated trophoblast cell types in the labyrinth arise from distinct and autonomous precursors in the chorion that are patterned before morphogenesis begins...

The basic helix-loop-helix transcription factor Hand1 regulates mouse development as a homodimer