March 3, 2015

Researchers reported a dose-response association between paracetamol and adverse events similar to those observed with NSAIDs, including mortality, CV, gastrointestinal and renal adverse events, according to results of a systematic literature review.

“Although the studies we included contained somewhat imperfect data — as long-term observational studies usually do, with all sorts of biases that cannot be easily detected, such as use of over-the-counter medicines — people taking paracetamol long-term, especially at higher doses, were at risk for problems that are usually not thought of as side effects of paracetamol,” Philip Conaghan, PhD, FRACP, FRCP, professor of musculoskeletal medicine at the University of Leeds, told Cardiology Today.

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