Trying to be reasonable in an unreasonable world.
Optimistic when possible; cynical when necessary.
Offering the world sporadic musings since 2005.
Elated supporter of the 44th President of the United States, Barack Obama

Sunday, February 05, 2006

Man-beast cloning update

I went looking for what exactly these man-animal clones are that have Mr. Bush's panties in a twist and found this thoughtful explanation by Dr. Myers of the University of Minnesota, Morris, of what scientists are up to (scroll way down when you get to his site):

Let's consider one recent example of such an experiment.

Down syndrome is a very common genetic disorder caused by the presence of an extra chromosome 21. That kind of genetic insult causes a constellation of problems: mild to moderate mental retardation, heart defects, and weakened immune systems, and various superficial abnormalities. It's also a viable defect, and produces walking, talking, interacting human beings who are loved by their friends and families, who would really like to be able to do something about those lifespan-reducing health problems. We would love to have an animal model of Down syndrome, so that, for example, we could figure out exactly what gene overdose is causing the immune system problems or the heart defects, and develop better treatments for them.

So what scientists have been doing is inserting human genes into mice, to produce similar genetic overdoses in their development. As I reported before, there have been partial insertions, but now a team of researchers has inserted a complete human chromosome 21 into mouse embryonic stem cells, and from those generated a line of aneuploid mice that have many of the symptoms of Down syndrome, including the heart defects. They also have problems in spatial learning and memory that have been traced back to defects in long-term potentiation in the central nervous system.

These mice are a tool to help us understand a debilitating human problem.

George W. Bush would like to make them illegal.

Dr. Myers explains it in close to layman's terms so that almost all of us can understand the procedure...and the humanitarian motives. Almost all of us.