In the United Kingdom, Panini Comics prints its Collectors' Edition (CE) line, which consists of reprints of Marvel US Comics. These are usually 76 pages long (with the occasional 100 page special), and the current cost of the comics is £3.50. A subscription offer is also available, and each comic is published every 28 days, with the exception of Astonishing Spider-Man which has been published fortnightly since volume 2.

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It obtained the Marvel UK license in 1995, enabling it to publish reprinted American Marvel Comics titles, and is also the company responsible for printing the Doctor Who Magazine. Panini Comics, had been part of Marvel Europe, and had already been reprinting American material across Europe for several years.

Thanks to this licensing deal, reprints of American Marvel Comics material were continued in the UK by Panini from the mid-1990s. Each book contained approximately two or three Marvel US strips in one issue with possibly a "classic" comic printed as a substitute for a comic in the current run, whilst being priced at a reasonable level. Initially the lineup consisted of only Astonishing Spider-Man and Essential X-Men and followed the continuity of the US comics, however it was approximately two–three years behind the current run in America.

In addition to reprinting the mainstream US comics, Panini also published a monthly (later every three weeks) over-sized comic, entitled The Spectacular Spider-Man, for younger readers to accompany Spider-Man: The Animated Series, which began broadcasting in the UK in the mid-90s. Initially, the stories were simply reprints of the US comics based on the series, but eventually the title moved to all-new UK-originated stories, marking the first Marvel UK material featuring classic Marvel characters to be produced since early 1994.

Since then Panini extended their line to include other characters within the Marvel Universe. In addition to Essential X-Men and Astonishing Spider-Man came Wolverine Unleashed, in which Wolverine's solo comic was reprinted. The comic ran for 54 issues before it was renamed Wolverine & Gambit to allow reprints of the Gambit series, and subsequently Wolverine and Deadpool when the Gambit material had been exhausted and Deadpool was introduced as a replacement in 2004. Marvel Heroes Reborn was released in 1997, to introduce the new Heroes Reborn saga, and expand the range of characters in Marvel UK's lineup. It was initially published with only two strips (or 56 pages) but this was expanded to 76 pages (commonly 3 strips) from issue 17 onwards. Unfortunately, this title was short lived due to continuously lagging sales, and was eventually cancelled in 2000.

In March 2006, Marvel Entertainment and Panini S.p.A announced that they had "renewed and expanded their publishing agreement under which Panini retains a master license for producing translated versions of Marvel comics for Europe and selected Latin American countries. The new agreement includes a major expansion of editorial projects in which Panini will originate new content under the creative supervision of Marvel."[2] This made them the "master license holder" for Europe and parts of Latin American and lead to the development of non-English language titles with Marvel, including Wolverine: Saudade, by Jean-David Morvan and Philippe Buchet,[3] and Daredevil & Captain America: Dead On Arrival, by Tito Faraci and Claudio Villa.

Alongside these mainly reprint titles, Panini continues to print Doctor Who Magazine which still features originally produced comics by British creators, something Panini do in their other titles. This includes the first new Captain Britain story by a British creative team in over a decade which was created by Jim Alexander, Jon Haward and John Stokes in Spectacular Spider-Man (UK version) #114 published in March 2005. Also published from 2004 onwards was Marvel Rampage, which like Spectacular Spider-Man was aimed at a younger audience, and similarly featured all-new UK-originated material, this time featuring characters from all across the Marvel Universe. Several of those short stories were written by noted Spider-Man writer Roger Stern.

Panini also release their own range of trade paperbacks. These are all reprinted material from the American originals, and can be bought from their online shop. They have also been printing a seemingly highly successful series of A.T.O.M. comics, which followed on from their Action Man, though it was recently cancelled.

The UK site also has a popular forum, primarily for discussion of Panini Comics' publications and comics in general as well as promotion of British Comic Conventions. It has around 580 members and 580 posts as of August 2011. This closed down in March 2013 and a new forum was set up by its members.