HIFU is the upcoming technology for noninvasive or minimally invasive tumor ablation via the localized acoustic energy deposition at the focal region within the tumor target. The presence of cavitation bubbles had been shown to improve the...

There are not enough donor lungs available to meet the increasing demand for lung transplantation. To compound the problem, transplant recipients have a projected survival time of only 5.7 years despite life-long immunosuppression. An alternative...

In 2005, 1.6 million Americans lived with a debilitating amputation and this figure is predicted to double by 2050. But the ability of a mammal to recapitulate a complex limb structure is not impossible. Evidence of children and mice re-growing...

Each year, more than 185,000 people in the U.S. lose a limb to injury or pathological conditions. Currently, the only replacement for amputated limbs is the fitting of a prosthetic device. While artificial limbs greatly enhance the lives of...

Mycobacterium tuberculosis (Mtb) remains a pathogen of significant importance with respect to global health. Although approximately one third of the world is infected with TB, only 5-10% develop clinical manifestations of active TB within 2 years...

The blood and lymphatic vascular systems coordinate to play critical roles in tissue fluid homeostasis and immune function and are fundamentally associated with diseases including inflammation, wound healing, edema, and tumor progression and...

PURPOSE. To image the fundus non-invasively at two different penetration depths using a multispectral imaging system. Monochromatic images at visible spectrum wavelengths and near-infrared wavelengths were qualitatively assessed for choroidal...

Background: Chronic wounds are a serious medical condition affecting over 6 million people in the United States. Biofilms, which are communities of bacteria attached to a surface and protected by a polysaccharide coating, are intimately associated...

Understanding angiogenesis increases comprehension of pathological conditions such as tumor growth and peripheral artery disease. Angiogenesis is the growth of new vessels from pre-existing vessels and commonly associated with two modes: capillary...

Mycobacterium tuberculosis (Mtb) is the causative agent of the disease tuberculosis (TB). While approximately one third of the worldâ€™s population is infected with this pathogen, only a small minority of these individuals has active TB infection,...

Opioids acting at the mu (morphine) receptor represent the vast majority of clinically used opioids and remain the most effective analgesics for treating moderate to severe pain. The use of morphine and similar compounds for the management of pain...

Soft tissue reconstruction in the nervous system is sensitive to the mechanical and chemical cues of the growth microenvironment. Many technologies have been designed to study these stimuli and their effect on the regional extracellular environment...

Research using the adult mammalian model shows that regeneration in the limb is limited to the distal most portion of the terminal phalanx. Recent studies suggest that the cellular contributions made to the regenerating system are lineage...