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Clinical measures are less sensitive to change thanobjective measures, such as neurophysiologic or electromyographic measures. In this case TCR antigen activation of theaffected CD8 T cells is temporarily blocked because other aspects of TCR activation such asthe phosphorylation of CD3zeta, ZAP70, and PKC-theta are unaffected (Baatar 2009)

In this case TCR antigen activation of theaffected CD8 T cells is temporarily blocked because other aspects of TCR activation such asthe phosphorylation of CD3zeta, ZAP70, and PKC-theta are unaffected (Baatar 2009).

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