Doc Holliday (Val Kilmer) kills Johnny Ringo. Wyatt Earp (Kurt Russell) and friends continue to hunt down members of the Clanton gang and all those who are cowboys. Before dying, Doc tells Wyatt that there's no such thing as a "normal" life and that he should go hook up with that actress. Some time later, Mattie (Wyatt's wife) dies of an overdose. Virgil and his wife move to California where he becomes sheriff. Ike Clanton is killed some time later in a failed bank robbery attempt. Wyatt hooks up with the actress (Josephine) and they have "some adventures together, some good and some bad." Wyatt Earp dies in 1929.

When Curly Bill is shooting up the town while drunk, he fires about 10 more rounds than his six shooter can hold without reloading, and still has a round remaining when he shoots Marshal Fred White. In the 1880 court hearing held after Marshal White's death, Curly Bill still had 5 rounds remaining in his pistol.

Val Kilmer has been quoted as saying that screenwriter Kevin Jarre insisted the actors wear real wool costumes, in accordance with the time period. During the scene in the Birdcage Theater, Val Kilmer says, a thermometer was placed on the set, and it read 134 degrees Fahrenheit. Kilmer suggested jokingly that this was the reason Doc Holliday killed so many people: "It's just, like, he wore wool in the summer, in the Arizona territory, and that made him mad."