A research team led by Karina Xavier at the Instituto Gulbenkian de Ciência (IGC, Portugal) has shown that bacteria living in the intestine both talk and listen to each other. Using small molecules in place of words, these microbial conversations changed the numbers of certain species of bacteria in the gut and started to restore the huge damage caused by lasting antibiotic treatment.

The findings, published in the scientific journal Cell Reports, show the potential to be gained from using bacterias own language to communicate with, control and exploit the multitude of microbes that live inside of the human gut.

Bacteria were long seen as predominantly harmful organisms, responsible for many illnesses across the world. This picture has been changing over the last ten years. Scientists are now reporting many beneficial characteristics of certain bacterial species, particularly those living inside human bodies, in particular in the intestine.

These microbes can be seen as tiny lodgers in the gut, helping the body to get the most out of ingested food and protecting from opportunistic invaders that cause disease. “When we lose some of these lodgers: by taking antibiotics or changing our diet, for example, the resulting imbalance in the community of bacteria can leave us at risk of infection, inflammatory bowel disease, obesity, or cancer,” explains Karina Xavier. Therefore, scientists like Karina Xavier are keen to understand how these bacteria interact, and then use this knowledge to benefit human health.

One way that bacteria can interact is through a sort of chemical language. Bacteria can produce and inter-change small molecules known as autoinducers. Detection by other bacteria enables these microbes to synchronously regulate behaviors in the community, in a process named quorum sensing.

Many of these signals are specific to individual species of bacteria, but the production of and response to one molecule, Autoinducer-2 (AI-2) can be seen throughout the bacterial kingdom. As this signal, AI-2, can foster inter-species bacterial communication and enable bacteria to modify behaviors, the research team led by Karina Xavier investigated the role of AI-2 as a language to communicate between bacteria in the mammalian gut.

“We know that bacteria can interact with each other in our test tubes in the lab,” said Jessica Thompson, one of the first co-workers in this study, “the big question was if it would happen inside the body, and what these conversations might mean for us, the bacteria’s hosts.”

Using the laboratory mouse as a model organism, the researchers were able to confirm that AI-2 is produced and sensed by Escherichia coli (E. coli) bacteria in the gut.

Next, the researchers addressed whether this molecule could influence the composition of bacterial species in the gut after antibiotic treatment.

The vast majority of bacterial species present in the mouse gut belong to two main groups – Bacteroidetes and Firmicutes. The researchers observed that upon treatment with streptomycin, a powerful antibiotic known to cause imbalances in the gut bacterial community, the diversity of species decreased substantially, and almost all of the species that remained after the treatment belonged to the Bacteroidetes group. Remarkably, this community imbalance was reduced when mice were fed E. coli that could produce large amounts of AI-2.

These findings suggest that native bacterial signals might provide useful tools to restore or protect our beneficial bacteria from damage inflicted by antibiotics. For Ana Rita Oliveira, also co-first author of this study, “these results showed that bacteria chit-chat, using AI-2 as a language, was able to modulate the composition of gut bacteria. This is the first time that bacterial communication has been shown to have an impact upon the balance of species in the gut microbiota.”

Karina Xavier said, “this works shows that by manipulating bacteria’s chemical language we can manipulate the composition of the gut microbial community. Particularly exciting was the finding that increasing the universal bacterial signal AI-2 favored a group of bacteria which we know is essential for protecting the host from many infectious and inflammatory agents. Going forward I expect that by further understanding the mechanisms involved, we will be able to design strategies to ameliorate the effect of antibiotics against the “good bacteria” and use them to fight disease.”

Health News

The largest and most comprehensive analysis to date of the link between aspirin and cancers of the digestive tract has shown that it is associated not only with a significant reduction in the risk of developing bowel cancer but also of several other cancers that almost invariably fatal, such as pancreatic and liver cancers.

A team of researchers has developed specialized antibody-like receptor proteins that they believe could soak up the excess cytokines produced during a cytokine storm. This excessive immune response, sometimes seen in Covid-19 patients, can be fatal.

Working in a mouse model, researchers report that a single stressful event produced quick and long-lasting changes in astrocytes, the brain cells that clean up neurotransmitters after they've communicated information between nerve cells.

Non-small cell lung cancer (NSCLC) is the most commonly diagnosed cancer, and the leading cause of cancer death worldwide. More than half of NSCLC patients die after developing metastases. There are no tests currently that would allow doctors to identify patients where more aggressive therapy could reduce mortality. Researchers at Tulane University have identified a protein on tumor-derived extracellular vesicles that indicates if a NSCLC tumor is likely to metastasize, according to a new study in Science Advances.

The lens of the human eye comprises a highly concentrated protein solution, which lends the lens its great refractive power. Protective proteins prevent these proteins from clumping together throughout a lifetime. A team of scientists from the Technical University of Munich (TUM) has now uncovered the precise structure of the alpha-A-crystallin protein and, in the process, discovered an important additional function.

As a healthy heart ages, it becomes more susceptible to cardiovascular diseases. Though researchers have discovered that relaxin, an insulin-like hormone, suppresses atrial fibrillation (AF), inflammation, and fibrosis in aged rats, the underlying mechanisms of these benefits are still unknown. Researchers discuss how relaxin interacts with the body's signaling processes to produce a fundamental mechanism that may have great therapeutic potential.

A ketogenic diet produces health benefits in the short term. As the body burns ketone bodies as an alternative source of fuel, tissue-protective gamma delta T-cells expand throughout the body, but negative effects appear after about a week, researchers found in a study of mice.

Aging is a dramatic public health issue in the face of the current demographic changes: the proportion of 60 and over in the world's population will almost double by 2050. In this context, a new discovery has just broadened scientific knowledge. Researchers shed light on the mechanisms of senescence, by identifying a key protein associated with aging.