The current method to treat acute toxin poisoning is to inject antibodies, commonly produced in animals, to neutralize the toxin. But this method has challenges ranging from safety to difficulties in developing, producing ...

In a case series seemingly tailor-made for cinematic tragedy or farce, emergency physicians report severe botulism poisoning from a batch of potato-based "wine" (also known as pruno) cooked up in a Utah prison. The study ...

Botulism

Botulism (Latin, botulus, "sausage") also known as botulinus intoxication is a rare but serious paralytic illness caused by botulinum toxin which is metabolic waste produced under anaerobic conditions by the bacterium Clostridium botulinum, and affecting a wide range of mammals, birds and fish.

The toxin enters the human body in one of three ways: by colonization of the digestive tract by the bacterium in children (infant botulism) or adults (adult intestinal toxemia), by ingestion of toxin from foods (foodborne botulism) or by contamination of a wound by the bacterium (wound botulism). Person to person transmission of botulism does not occur.

All forms lead to paralysis that typically starts with the muscles of the face and then spreads towards the limbs. In severe forms, it leads to paralysis of the breathing muscles and causes respiratory failure. In light of this life-threatening complication, all suspected cases of botulism are treated as medical emergencies, and public health officials are usually involved to prevent further cases from the same source.

Botulism can be prevented by killing the spores by pressure cooking or autoclaving at 121 °C (250 °F) for 3 minutes or providing conditions that prevent the spores from growing. The toxin itself is destroyed by normal cooking processes - that is, boiling for a few minutes. Additional precautions for infants include not feeding them honey.