January 5 – Boston Red Sox pitcher Tim Wakefield escapes serious injury when he is hit by a car while out jogging. He is released from the hospital after being treated for bruises.

January 6 – Pitcher Phil Niekro is elected to the Hall of Fame by the Baseball Writers' Association of America. Niekro receives 80.34% of the vote. Pitcher Don Sutton falls nine votes short of election.

April 15 – On the fiftieth anniversary of Jackie Robinson's first game, all Major League baseball games are stopped so that fans across the country may witness a special presentation at Shea Stadium. With then U.S. President Bill Clinton alongside, acting Commissioner Bud Selig announces that Robinson's uniform #42 will be retired from all Major League teams in perpetuity, with exceptions made for players currently wearing #42 in honor of Robinson.

May 8 – At home, the Baltimore Orioles stop Randy Johnson's 16-game win streak with a decisive 13–3 pasting of the Seattle Mariners. Baltimore is led by catcher Chris Hoiles, who collects six RBI on two homers and a double. Johnson strikes out 10 in six innings, but gives up five runs on six hits and two walks in his attempt to become the first AL pitcher since Dave McNally (1968–69) to win 17 straight.

May 26 – In Toronto, Roger Clemens allows one run and four hits in seven innings and strikes out seven to beat the Texas Rangers 8–1. The Rocket is now 9–0, his best start since beginning 1986 at 14-0.

May 27 – Barry Larkin's streak of consecutively reaching base 13 times is stopped by Curt Schilling, who goes all the way to beat Cincinnati 2–1. Larkin singles in the first inning, but flies out in the 3rd to end his streak one shy of Pedro Guerrero's NL record, set in 1985.

May 31 – Cal Ripken, Jr. snaps a seventh-inning tie with a record-breaking home run as the Baltimore Orioles rally from a four-run deficit to beat the Cleveland Indians, 8–5. Ripken's homer gives him 4,274 total bases with Baltimore, breaking the franchise mark for total bases in a career. Baltimore also places Eric Davis on the disabled list. Davis is suffering from colon cancer and will be operated on in early June.

July 12 – At a sold out Three Rivers Stadium, Francisco Córdova pitched nine innings of a combined 10-inning no-hitter for the Pittsburgh Pirates. Ricardo Rincón pitched the 10th inning. The Pirates won the game on a dramatic three run, pinch hit home run in the bottom of the 10th by Mark Smith.

August 8 – For the second time this season, Randy Johnson of the Seattle Mariners records a 19-strikeout performance at the Kingdome, this time against the Chicago White Sox. Unlike his 19-K performance on June 24, Johnson comes out on top, shutting out the White Sox 5-0.

September 5 – At 3Com Park, Barry Bonds of the San Francisco Giants becomes a five-time member of the 30–30 club. Batting in the sixth inning of the Giants' 4-1 victory over the Houston Astros, Bonds, who has 32 home runs to this point, reaches first base on pitcher Shane Reynolds' error, then steals second, his 30th stolen base of the season, on a Jeff Kent strikeout. With this steal, Bonds ties his father Bobby for most seasons with both 30 home runs and 30 stolen bases.

September 19 – Mark McGwire records his 20th home run of the season with the St. Louis Cardinals. Paired with the 34 home runs he had hit with the Oakland Athletics earlier in the year, he becomes the first player in Major League history to record twenty or more home runs for two different teams in the same season.

November 12 – Ken Griffey, Jr. of the Seattle Mariners becomes the ninth unanimous pick for the American League MVP Award. Griffey hit .304 for Seattle, led the AL with 56 home runs, and led the Majors with 147 RBI. He receives all 28 first-place votes and 392 points in balloting to become the first unanimous AL pick since Frank Thomas in 1993, and the 13th unanimous selection overall.

January 20 – Curt Flood, 59, All-Star center fielder who won seven Gold Gloves and batted .300 six times; challenged baseball's reserve clause all the way to the U.S. Supreme Court, unsuccessfully, after refusing a trade

July 31 – Eddie Miller, 80, 7-time All-Star shortstop for four NL teams who led league in fielding five times

August 12 – Rex Barney, 72, pitcher for the Brooklyn Dodgers between 1943 and 1950, who threw a no-hitter against the New York Giants in 1948

August 23 – Guy Curtright, 84, White Sox outfielder who finished sixth in 1943 American League batting race with a .291 average

August 23 – Buddy Hassett, 85, first baseman who played from 1936 through 1942 for the Brooklyn Dodgers, Boston Bees/Braves and New York Yankees

September 9 – Richie Ashburn, 70, Hall of Fame center fielder for the Phillies who batted .308 lifetime, winning two batting titles, and led NL in putouts nine times, hits three times, triples twice and steals once; retired with six of the top eight single-season putout totals in history