National Geographic Traveler magazine has announced its annual list of their picks for Tours of a Lifetime, selecting 50 fantastic journeys to the far flung corners of the globe. For each of the past six years, Traveler has examined thousands of tours in a variety of categories, including volunteer vacations, family friendly trips, small-ship voyages, and adventure travel. From all of those itineraries, they’ve narrow down their choices to this select group, which represent the absolute best in travel, offering amazing cultural experiences, unique activities, and a commitment to sustainability.

On their website, Traveler has broken down the selected tours into six regions of the world, including Africa, Asia, Central and South America, Europe, North America, and Oceania. By clicking on one of those options, readers are presented with the magazine’s recommendations for the very best tours operating in that area, complete with a brief description, links to the tour operator’s website, and price, which can vary wildly depending on the destination and options.

Amongst the selections for this year’s Tours of a Lifetime are Serengeti bush treks, whitewater paddling in Siberia, and a journey deep into the interior of Guyana. There is a journey along the Inca Trail on horseback and cycling tours of Italy and France, as well an expedition to the South Pole on skis. In short, there is a little something for everyone, depending on their interests and budget.

Since all of these trips are researched and vetted by National Geographic, you can rest assured that all of the tour operators are not only legitimate, but also top tier. These trips were specifically selected because they offer something that is a little out of the norm. Something unique that you can’t generally get anywhere else. I’m pretty sure, even if you think you’ve been everywhere and done everything, you’ll still find something to appeal to you on this list.