Monthly Archives: October 2012

[Warning: Don’t start buying and using Growth Hormones hoping to increase your height unless you are absolutely certain that it is safe (or maybe just don’t care). GH is not recommended or even allowed legally into certain countries for people who are still growing and GH will not work for people who can take them legally which is after growing stops. It is sort of like a catch-22 people get stuck in. The only way legally to get around the loophole is if a person can get a specialist endocrinologies tho administer it to them clinically.]

I have recently become aware that there seems to be quite a few suppliers around the world which can get you synthetic Growth Hormones. Obviously the problem is that sometimes these suppliers don’t get you real GH but fake stuff.

There is a company from South China Sino Human Growth Hormone Pharmaceutical Co., Ltd which seems to sell almost everything. It is really hard for me to tell whether they sell the real GH stuff or the fake stuff. There are a few places where buyers and users review them but they are rather mixed.

From the website Eroids.com, most people who comment say that the company has “legit stuff” and has “good quality”. There seems to be even a linkedin account for Sino HGH and and the managers there and more. from the linked in account…

“Sino Co., Ltd is a company which specialize in human grow hormone,anabolic steroids,and peptides. We have own lab to produce finished prdocuts. Sino Human Growth Hormone Pharmaceutical Co.,Ltd.We aim to be the best and the largest HGH, Injectable Steroids, oral steroids, anabolic steroids powder and Peptides supplier in China. Our company is located in Shenzhen since 2003, we gained a great reputation among our customers because of our professionalism in United States, United Kingdom, Europe,South Africa,South Asia,Latin America,etc. Best quality, fastest delivery,safest packing,most timelyaftersales service are the keys that we got credit from our clients all over the world. It is our ultimate goal to extend market presence to every part of the world. We warmly welcome sincere cooperation with customers from at home and abroad to explore a bright future together.”

One thing I am not sure is whether it is possible that good steroids and peptides can go bad if the inventory is shelved for too long like food stuff. If that is case maybe the stuff the Chinese company was originally selling was good but went bad.

The price range for the steroids and peptides, which include many types of steroids which I have researched for possible height increase possibilities are quite reasonable.

The cost of shipping is from $45-$100 assuming the stuff is being bought by people in the US and UK. The amount of time you have to wait is usually 7-10 business days. They only accept Western Union, money grams, and bank transfers, but no Paypal or other escrow methods. (taken from FAQ section) The success in the delivery is not very high for certain countries.

Of course you always have the contact information below for any types of inquiry or concerns.

While I don’t plan to be taking the GH injections anytime soon since it won’t really help increase height, it might be a good place for us to buy GH in case we are interested in doing a few studies and experiments. If a young person is crazy and desperate enough, I probably would point to this company to use so that they at least don’t get the fake stuff which can hurt them.

From this perspective article entitled “Mechanical Effects on Skeletal Growth” we learn about a very important law that is extremely applicable to our endeavor since it sort of validate old wives tales and common sense. If you exercise or push too much axial load on your bones when you are still young and can grow, you can possibly stunt your growth and decrease what would be your final height. The Hueter-Volkmann ‘Law’ implies a continuous monotonic relationship between loading and growth modulation. From the article…

“The ‘Hueter-Volkmann Law’ proposes that growth is retarded by increased mechanical compression, and accelerated by reduced loading in comparison with normal values”

and…

“The gross effect of growth modulation has been demonstrated qualitatively and semi-quantitatively. Sustained compression of physiological magnitude inhibits growth by 40% or more.”

To validate this law…

The mechanical modulation of epiphyseal growth is often referred to as the ‘Hueter-Volkmann Law’. Mechanical modulation of longitudinal growth by compressive forces is the most widely recognized, but tension, torsion and bending are also reported as having an influence on the longitudinal, rotational and angular development. While growth responds to sustained load, bone remodeling responds primarily to transient loading 5 . Intuitively it would appear that if bone growth responded to transient forces, then active children would achieve different stature than their less active peers. However, recent data suggest that intermittent large compressive stresses do reduce endochondral growth in the rat forelimb.

There has been clinical studies where it was observed that the spinal longitudinal growth was more because the vertebrate was not loaded as much.

A similar concept has been proposed in the mechanism of scoliosis progression during growth. In the spine, Gooding and Neuhauser reported “tall vertebrae” in patients with paralysis and also in younger patients who had been treated surgically with posterior fusion of the spine. They argued that the relative unloading of the spine produced increased longitudinal growth, although this was contested by Taylor. McCall et al. similarly reported on 3 patients who had increased height of the vertebrae (and thinner discs) secondary to long-term immobilization in plaster for treatment of idiopathic scoliosis.

Me: It seems that I am finding many websites and company these days which supply the actual components and raw material needed to perform actual experiments to test animals or our bodies to see if they can work for height increase. I have found a company which can supply the chondrocyte needed to perform experiments dealing with growth plate regeneration, the BMPs and growth factors needed to inject into the chondrocyte mediums, and the Growth Hormones and peptides used in Gh therapy. This post is to show the reader where to actually buy the specific types of BMPs I have been talking about for so long. If we can get the right raw materials, we can get microscopes, adult mice or rabbits from the pet store, and do histological testing after injections to see what happened to the long bones under real controlled experiments. I do know that there are already many DIY (do it yourself) biology and genetics labs across the US and if we can put a little money in, we could rent out a small space of a biotech company to perform our experiments.

Apparently there is this company Invitrogen or Life Technologies which sells at least the BMP-2, 4, 7, and the BMPR1A . Maybe they sell more. The section is the “Growth Factors, Chemokines & Cytokines” section.

I know that from Tyler’s website HeightQuest.com that he has adsense ads which direct you to the Invitrogen website. I have been here before since they also sell chondrocyte growth cultures and growth factors.

You can also find the Manuals & Protocols document and MSDS PDFs on the same page

BMP7 (Active) Recombinant Human Protein

(Gibco®)

Description

Recombinant human BMP7 is a bioactive protein intended for use in cell culture applications. BMP7 is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site.

BMP2 Recombinant Human Protein

(Gibco®)

Description

Recombinant Human Bone Morphogenetic Protein 2 (BMP2)is a bioactive protein intended for use in cell culture applications. BMP2is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. BMP2acts as a disulfide-linked homodimer and induces bone and cartilage formation.

• High purity – no interference from other proteins or contaminants
• High biological activity – more results with less protein
• Proven compatibility – Gibco® proteins bioassayed with Gibco® media

High Purity Recombinant Bioactive Protein

Recombinant Human Bone Morphogenetic Protein 2 is one of more than 250 Gibco® recombinant proteins available from Life Technologies. To help ensure Gibco® growth factorsView More

Me: The study seems to suggest that you can delay and prevent the closure of the physics (growth plate) if you can cause even the slightest of distraction in the epiphysis and inject even a little bit of chondrocyte the lengthening process can be extended leading to more height increase. This validates to a slight extent the idea of possibly putting a type of growth plate implant into the long limbs so that they can continue to or restart to lengthen again. However, the issue is that if you just use chondrocyte injections, the effect seems to only go towards the hypertrophic zone and the chondrocytes start to cluster which previous experiments have shown was not a good thing in the resting zone.

From the study “The purpose of this study was to determine if cultured chondrocytes could prevent premature closure of the physis after physeal distraction in a rabbit model.” The actual experiment was ” injection of cultured chondrocytes after epiphyseal distraction” . The conclusion was that “The zone of hypertrophic chondrocytes was enlarged. It appears that the injected cells differentiated into hypertrophic chondrocytes and delayed premature physeal closure. At 10 weeks after distraction of the physis, the width of the physis was restored to 75% of normal, but disordered chondrocyte growth with cell clustering was present in the cell-injected group.”

J Orthop Res. 2006 Mar;24(3):355-65.

Chondrocyte injection in distraction epiphysiolysis (rabbit model).

Ahn JI, Erdin RA, Smith R, Canale ST, Hasty KA.

Source

Abstract

The purpose of this study was to determine if cultured chondrocytes could prevent premature closure of the physis after physeal distraction in a rabbit model. Epiphyseal distraction at the proximal tibial epiphysis was performed in 24 immature rabbits. Chondrocytes were harvested from the iliac apophysis. The animals were divided into three groups: A, epiphyseal distraction alone; B, injection of phosphate buffered saline (PBS) after epiphyseal distraction; and C, injection of cultured chondrocytes after epiphyseal distraction. After epiphyseal separation was noted radiographically, each animal was evaluated at routine intervals. At 2 to 4 weeks, significant tibial lengthening as compared to the contralateral tibia was noted in all three groups. At 10 weeks, lengthening was apparent only in group C; in groups A and B, the operated tibia was shorter than the unoperated one. Histologic examination at 4 weeks revealed partial bony bridge formation with cell clustering in the fibrocartilaginous matrix in groups A and B. In group C, the matrix showed a typical hyaline aspect with cells organized in columns at the injection site. The zone of hypertrophic chondrocytes was enlarged. It appears that the injected cells differentiated into hypertrophic chondrocytes and delayed premature physeal closure. At 10 weeks after distraction of the physis, the width of the physis was restored to 75% of normal, but disordered chondrocyte growth with cell clustering was present in the cell-injected group.

Me: The researchers in this study wanted to see what would be the effect on periosteal division if the growth plates are either distracted or compressed. Note that for 6 week old rabbits (still growing) which probably only weigh 2-3 kg with 1 kg of mass on both legs. This was done on the proximal tibial growth plate. What the researchers did was slice a piece of the periosteum layer off for about 1 cm on one half of the tibia. It seems that compression will inhibit the tibial growth and distraction enhance it, at least in the area where the compresion & distraction was done on. What is really strange is that the opposite effect is sense on the other end of the bone. As stated from the abstract “Periosteal division enhanced growth at the adjacent growth plate but inhibited it distally; the effect of distraction was enhanced and that of compression reduced.” remember that it is the proximal tibia we stripped on. What is important to note is that with these young, still growing rabbits, even small amounts of compression or distraction did affect bone growth. The periosteal division does seem to induce overgrowth by some type of mechanical effect but I am not sure how the process would even work. It is very interesting that the end of the abstract mention that this type of method of compressing and distraction certain areas of the long bones like the tibia can be using along with (or added as a side part) of certain types of limb lengthening but not epiphyseolysis (why can’t it be used for epiphyseolysis I don’t know why??)

The relationship between periosteal division and compression or distraction of the growth plate. An experimental study in the rabbit.

Wilson-MacDonald J, Houghton GR, Bradley J, Morscher E.

Source

Nuffield Orthopaedic Centre, Oxford, England.

Abstract

We subjected the proximal tibial growth plates of six-week-old rabbits to either compression or distraction of 1 kg on both legs. On one side the proximal tibial periosteum was divided circumferentially and stripped for 1 cm. After six weeks, growth was measured at both proximal and distal growth plates. Compression inhibited total tibial growth and distraction enhanced it. The compressed growth plate grew less and the distracted growth plate grew more, but there was a reciprocal change at the other end of the bone. Periosteal division enhanced growth at the adjacent growth plate but inhibited it distally; the effect of distraction was enhanced and that of compression reduced. We found reciprocal growth rates at the proximal and distal growth plates. Relatively small amounts of compression or distraction did affect total bone growth. Periosteal division appeared to induce overgrowth at least partly by a mechanical effect; it may be useful as an adjunct to other methods of leg lengthening, though not to epiphyseolysis.

So here are the results for the traffic that has been going through my website for the month of October. This will be a monthly thing to show the regular readers how this website has been developing and growing over time.

Overall, this month has seen a few changes with the website on how it is presented in terms of graphical layout. I have been trying more and more to focus on less quantity, and more quality in the posts. Some are quite informative and long. The number of emails I am getting these days and me daily email exchanges with people have gone up dramatically. Overall it has been a great and enlightening experience as they give me feedback on what they like and don’t like about the website. Then, I go back and work and edit the website to make it more user friendly for them. The number of people checking out the Facebook page and the likes have also been increasing.

I’ve added a few features, like a mailing list at the bottom of the page, thought about adding a forum, combined a few old sections which no one was looking at, and made a bigger effort to get the readers to the right direction. Also, I am going to try to apply and get a podcast going for the website to increase the audience.

So here is the report from Clicky below.

Analysis: What seems to have happened from the end of September to the end of October is that the total number of visitors have increased from around 4700/month to 9500/month. At the currently time the number for October is only less than 9100 but these days the number of visitors is actually around 400 total visitors/day. I am assuming and calculating to the end of the day. My highest number was yesterday at 452 which is extremely high. For september, the number was around 200 visitors per day so the traffic has increased by about 100% again. Obviously this trend of doubling each month is impossible to sustain in the long run. I am willing to calculate that the traffic will not be increasing much higher after November since the rate at which I am producing posts and articles has dropped dramatically as I have shifted my focus on working on my primary company and business.

As always, it is always important to realize that the numbers are NOT for an entire month which is usually 30 or 31 days but 28 days. Clicky does give me the option of looking at the traffic data of a month but I have to wait until the next month. I really just wanted to get this monthly report published quickly so I can move on in researching.

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This website is a research based website, and currently has nothing for sale. We started out as a website looking for a way to help people grow taller, but originally focused too much on talking about other businesses and their products. That has forced the website into multiple uncomfortable legal issues. Those will be resolved. We no longer do that. Our focus is now on the research, the reporting, and the science.