There should not be any issues with compatibility with CS6. However, our installer has not yet been updated to automatically download straight to your filters folder, so you will have to manually configure it with a few simple steps.

For setup, try this:

For Windows:

Please go to your preferences menu in Photoshop and select Plug-ins. Check / enable the Additional Plug-ins Folder option then click Choose. After that, please navigate to: C: \ Program Files and select the Topaz Labs folder. Then click Choose Â (or it may say Save / OK) to save this back to Photoshop. Back in Photoshop click OK to save your changes, then restart Photoshop. Once Photoshop opens, go to your Filter menu and you should be able to access Topaz.