SharePoint 2016 on premise - is there any part of building new sites that will NOT work with responsive design?

SharePoint 2016 on premise - is there any part of building new sites that will NOT work with responsive design?

With frameworks there is always a way to find a solution, but sometimes its just best to stay away from certain things on mobile. Does anybody have a SharePoint 2016 on prem horror story of something they thought would work great on mobile / responsive design that just went horribly wrong?

I have read that SharePoint 2016 support mobile design, but for fully responsive we should build the web parts using React or Angular for full responsive. However I am sure there are limits and things that we should never attempt to do on Mobile. Please share any of those experiances