The series first started with the events of Tsukihime which is directly connected to the sequels and spinoffs. Kagetsu Tohya and Melty Blood both acts as sequels taking place one year later after the events of the first Tsukihime game. Melty Blood is supposed to follow the canceled project of Satsuki Yumizuka's route which was originally planned for Tsukihime. Melty Blood Re-ACT and Melty Blood Act Cadenza are expansions of the original game but in Melty Blood Act Cadenza, almost all events that occur in the story-modes of the characters in this game are set in events based on alternate realities and different timelines that are totally out of current chronological timeline of Tsukihime/Melty Blood series (except certain story-modes of some characters). Melty Blood Actress Again is as a direct sequel to the story mode of Melty Blood.

Hana no Miyako is a spin-off story of the Melty Blood manga, featuring Miyako Arima as the protagonist. This manga also involves other type-moon characters in the story.