Research Interests

My lab works on the determination of the structural and dynamic basis for the function and operation of complex protein machineries that are involved in key biological processes. We aim to understand at the atomic level how these machineries work inside the cell. We combine high-resolution NMR spectroscopy with other structural biology approaches to gain unprecedented insights into the sophisticated mechanisms of action of the following protein systems:

Protein kinases, such as the Bcr-Abl causing chronic myelogenous leukemia

Molecular chaperones, such as the Hsp90 and Hsp70/40 families involved in cancer

The injectisome and the flagellum machineries in pathogenic bacteria involved in infectious diseases