One thing is now clear; a little hypertension can be lethal, and rigid normalization of the pressure prolongs life and reduces cardiovascular sequelae of hypertension, possibly including coronary heart disease. There is little excuse for not treating hypertension, including mild hypertension. However, while all hypertension should be treated, for some, ...

A method for the quantitative analysis of the percent metabolism that results in covalent binding of 7,12-dimethylbenz[a]anthracene (DMBA) to DNA in viable resting human lymphocytes is described. The inter- and intra-experimental reproducibility as judged by the coefficient of variation and examined in the same individual over a 3-month period was ...

Neither blood pressure measurements nor other clinical features permit an entirely adequate characterization of individuals having mild hypertension. However, although any definition of mild hypertension is arbitrary, the concept is firmly established in clinical practice and such classifications can prove useful as operational diagnoses. The relative risk of subjects with ...

alpha-Methyl-p-tyrosine is an orally active inhibitor of catecholamine synthesis which inhibits the hydroxylation of tyrosine to dopa. At dosages of 600 to 3500 mg daily it is effective in controlling the hypertensive episodes and symptoms of catecholamine excess in phaeochromocytoma during preparation for surgery. Limited published experience suggests that it ...

A community control program for hypertension was instituted during 1972 and 1977 as a major subprogramme of the North Karelia project. The aim was to reduce the high blood-pressure levels prevalent among the whole population of the county of North Karelia. A community-based hypertension register, established according to the recommendations ...

The prevalence of secondary and curable hypertension was studied retrospectively in 1000 patients. The concept of "secondary hypertension" was used when hypertension was combined with a disease which may have affected the individual's blood pressure. When this definition was applied, 47 of the patients displayed some form of secondary hypertension: ...

Hypertension may be considered a disorder of increased energy in the blood, with two components: increased pressure energy may promote arteriolar disease, whereas arterial diseases such as atherosclerosis may be more closely related to flow disturbances (turbulence, boundary layer separation, high shear, or axial stream impingement) due to increased kinetic ...

1. Interference with neuronal transmission through the NTS can result, depending upon species and mode of perturbation, in a panoply of abnormalities of blood pressure control simulating many of the features of the human disease. These are summarized in Table 1. 2. The abnormalities of pressure control resulting from abnormal ...

Hypertension is a common disease which may often be modified, sometimes cured and, perhaps in some cases, prevented. This communication emphasizes the importance of obtaining blood pressure measurements in children no later than at the age of 3 years and sequentially thereafter, and stresses the importance of using techniques for ...

Hypertension secondary to hydronephrosis is uncommon, and when a duplex system is involved it is rare. A patient presenting with hypertension and an abdominal mass on the left side was found to have a non-functioning, massively dilated upper pole of a duplex system causing hyperreninemic hypertension. Treatment consisted of an ...

A community-based programme to improve awareness and control of hypertension was launched in 1972 in North Karelia. It was incorporated in the existing health-services system. An assessment five years later showed that, compared with a reference area not included in the programme, awareness of hypertension had improved, the prevalence of ...

The plaintiff alleged that failure of the attending physician to manage her husband's hypertension properly resulted in his death from intracerebral hemorrhage. Four lines of evidence supported the defendant: (1) In 1970 to 1971 there was uncertainty in the medical community whether mild hypertension should be treated with drugs; this ...

Even mild arterial hypertension dramatically increases the risk of vascular brain disease. Cerebral infarction is most commonly attributable to large-vessel thromboembolic disease. Lacunar infarcts, due to lipohyalin degeneration of vessel walls, are a particular hazard in the hypertensive patient. Hypertensive encephalopathy is associated with hypertension from any cause and may ...

Neurogenic hypertension may be reproduced consistently in experimental animals, although its clinical significance is unclear. An ectatic loop of the posterior inferior cerebellar (PICA) compressed the left vagus nerve root entry-exit zone in two patients with long-standing hypertension. When this loop was mobilized for occipital-PICA bypass, the hypertension resolved. These ...

The effects of reserpine on the blood pressure, heart rate, higher nervous activity and plasma catecholamine level during the development of neuropsychogenic hypertension induced by overstrain of the central nervous system have been studied in dogs. Overstrain (intensified tension) of the higher nervous activities was induced by a schedule or ...

Hypertensive patients may present to the emergency department with one of three general problems: high blood pressure due to labile hypertension, chronic hypertension, accelerated hypertension, or a hypertensive emergency; side effects from antihypertensive drugs; or acute medical or surgical illness whose management may be affected by hypertension or by drugs ...

Fluorophotometry was used to evaluate alterations in the blood-ocular barrier to fluorescein in rats with experimental hypertension. One hour after intravenous injection of fluorescein, 16.6 mg/kg, concentrations in the anterior chamber were increased from mean normotensive values of 135 micrograms/mL to 299 micrograms/mL (P = .005) in animals with severe ...

Cross-sectional surveys of arterial blood pressure among rural and urban communities in Bendel State, Nigeria, showed that mean systolic and diastolic pressures were generally higher in urban than in rural subjects, but the differences were statistically significant only in certain age groups. The mean arterial pressures in groups of rural ...

In an attempt to re-evaluate a possible high incidence of hypertension in hypothyroid patients, blood pressure was measured in 38 slightly hypothyroid patients, in 17 moderate hypothyroid patients, and in 26 severe hypothyroid patients. The data were then compared with the findings in 73 known euthyroid subjects and in 1,601 ...

In recent years interest has increased in the study of the metabolism of cadmium because of its presence in the environment as a toxic agent. Having no known essential bodily functions and possibly altering the action of various other trace metals, eg, lead and zinc, cadmium has been suspect as ...

The problem of cardiovascular reflexes in hypertension poses several questions. The first is whether alterations in cardiovascular reflexes can initiate a persistent increase in arterial pressure. Another is whether it is an alteration in depressor or in pressor reflexes that matters in hypertension. Other questions concern the type and nature ...

Juvenile hypertension is a new field of study, and a definitive approach to diagnosis and treatment has not yet been developed. This article outlines the approach at the hypertension clinic of Children's Hospital Medical Center, Cincinnati, where experience has confirmed the value of routine blood pressure measurement from an early ...

An 11-month-old boy had an episode of generalized convulsions followed by a right peripheral facial palsy, which resolved gradually within 3 weeks. Three months later he had another similar episode of convulsions followed by a left peripheral facial palsy. On both occasions it was found that he had polycythaemia. A ...

Two comparable rural communities but with varying endemicity of urinary schistosomiasis in environs of Ibadan, Nigeria, have been studied by a total cross-sectional population survey. It has been found that:- (i) schistosomiasis does not predispose to raised blood pressure (ii) both diastolic and systolic blood pressure increase with age. (iii) ...

The hypertensive encephalopathy is a syndrome consisting of a sudden elevation of arterial pressure usually preceded by severe headache and followed by convulsions, coma or a variety of transitory cerebral phenomena. The syndrome may complicate acute glomerulonephritis, toxemia of pregnancy and essential or malignant hypertension. Two syndromes must be differentiated ...

The interaction between noradrenergic and serotonergic mechanisms on the central regulation of blood pressure in the rat was studied, using central experimental hypertension produced by chemical lesions of the locus coeruleus (LC) with 6-hydroxydopamine (6-OHDA). The hypertension (LC-hypertension) was blocked by pretreatment with 6-OHDA intraventricularlly administered and also with desipramine. ...

The complications of mild hypertension especially involve progression to moderate or severe hypertension, coronary events, strokes, and congestive heart failure. Less often, other complications such as rupture of a dissecting aneurysm, retinal hemorrhages, hypertensive encephalopathy, and renal failure may occur. Total mortality clearly rises with progressive increases in systolic or ...

Hypertension has been observed to occur frequently in children with burns. In a series of children admitted to the St. Agnes Burn Treatment Center, sustained systolic and diastolic hypertension occurred in 31.5%, and 57.4% of the children demonstrated episodic periods of hypertension which were unsustained. The only clinical finding which ...

Our clinical experience and the literature regarding anesthetic management of the hypertensive patient are reviewed. Preoperative evaluation and treatment of all hypertensive patients, regardless of their degree of lability, is recommended. For emergency surgery on an untreated hypertensive patient, control of blood pressure with nitroprusside should be attempted before an ...

Systolic arterial hypertension in subjects with regional cerebral ischemia is considered and discussed as regards its frequency and its pathogenetic meaning, and criteria concerning the way of treating it. Systolic arterial hypertension presents a very high frequency in these subjects. At times it is accompanied by moderate diastolic hypertension, to ...

Due to conflicting reports in the literature regarding nerve conduction velocities (NCVs) in hypertensives, peroneal and sural NCVs and facial nerve conduction latencies were studied in 30 hypertensives and in 30 controls. An improved technique of NCV measurement was used. Twenty-one of the hypertensives were retested after five weeks, and ...

The prevalence of hypertensive levels of blood pressure was investigated in a random sample of 2535 adults in Napier in 1973. More than 70 percent of all persons examined had been measured for blood pressure within the previous five years. A retrospective analysis of results using the WHO classification indicated ...

Five children are described who developed hypertension in relation to acute neurological disease. Possible pathophysiological mechanisms for the hypertension are considered. It is thought that the hypertension may have been related to interruption of the ascending tracts in the brain stem, leading to failure of integration between, or independent action ...

A field study in an area of intense infection with Schistosoma haematobium showed a 6-6% prevalence of bacteriuria in males under 25 which was significantly greater than in a non-endemic area where no cases were found. In older subjects the prevalence in both areas was less than 1%. Similarly designed ...

An 18-year-old patient with catatonic schizophrenia developed hypertension when administration of antipsychotic medication was discontinued. Elevated blood pressure was sustained for three days until it was discovered that intramuscular administration of benztropine mesylate immediately reduced it to normal. The fact that the hypertension was not noted earlier while the patient ...

Progesterone (2.5 mg per kilogram) caused sustained hypertension in rabbits. When the same dose of progesterone was administered together with prolactin (1.25 mg. per kilogram), there was no increase in the blood pressure. In rabbits with progesterone-induced hypertension, the addition of prolactin caused a sharp drop in blood pressure. It ...

Although the possible role of hypertension and/or blood pressure variability in the causation of juvenile delinquency has not been directly investigated hitherto, there is evidence to suggest (a) that an excess prevalence of blood pressure variability rather than hypertension is the aspect of cardiovascular functioning which characterizes adolescents, and some ...

Hypertension has been found to imply a disease entity since the beginning of this century. Effective treatment available in the last two decades has changed the outlook remarkably, especially in malignant hypertension. There are more and more evidence that less severe forms of hypertension will benefit from keeping the blood ...

Systemic blood pressure is a vital sign and fundamental variable and as such the areas of its involvement in all individuals are indeed multifaceted. The purpose of this paper is to discuss the interpretation of systemic blood pressure readings as they specifically relate to a detailed analysis of hypertensive retinopathy.

Casual blood pressure was studied in a mixed community above 20 years of age and records of hospitalised patients for hypertension and/or its complications were analysed. It was found that about 2 percent of people examined were unaware that they had elevated blood pressure. High incidence of hypertension was found ...

Alterations in steroidogenesis have been demonstrated in experimental and human hypertension. It is highly likely that increased secretion of the nonaldosterone mineralocorticoid deoxycorticosterone (DOC) and 18-hydroxy-11-deoxycorticosterone (18-OH-DOC) may initiate or perpetuate hypertension, or both. It is possible that 16 beta-hydroxydehydroeplandrosterone (16beta-OH-DHEA) directly induces the hypertensive process in animals. The significance ...

Blood pressure levels among 322 shopkeepers and clerks, aged 14-90, were assessed by measurement during the interviews. An individual was classified as being hypertensive if his systolic pressure was at or above 160 and/or the diastolic pressure was at or above 95 mm.Hg. Seventy-six persons or 23.6% of the sample ...

The population of a community of 29,608 adults was screened door-to-door for elevated blood pressure. Of 12,371 adults screened, 20% were classified as hypertensive. After repeated blood-pressure measurement, however, there were only 9% with sustained hypertension, while 11% had labile hypertension. Sixty percent of the cases of sustained hypertension had ...

Problems of management in a child with a large Wilms' tumor and severe uncontrolled hypertension presenting for anesthesia and operation included attempts to determine the etiology of the hypertension; identification of hazards produced by attempted rapid pharmacologic control of blood pressure; need for urgent operative intervention despite uncontrolled hypertension; and ...

The entry of [125I]-labelled low density lipoprotein (LDL) into different regions of the aortic intima has been studied over a 6 hour period in both normotensive and renal hypertensive rabbits fed a normal diet. Studies have also been carried out in previously hypertensive rabbits in which the blood pressure was ...

Evidence is presented from studies of the authors and of other investigators that primary hypertension is more common in children than was previously thought. Ninety-five percent of 131 asymptomatic children with incidental hypertension were considered to have primary hypertension after investigation for possible causes. The definition of hypertension was based ...

The underlying causes of hypertensive disease remain unclear. This article has attempted to highlight potential dysfunctions in arterial pressure regulation which could either initiate or sustain the hypertensive process. As has been suggested innumerable times hypertension must certainly be a multifactorial abnormality. The current state of knowledge about control of ...

Autopsy studies of atherosclerosis of the aorta and the coronary arteries were carried out in 3134 subjects with essential hypertension. A comparison was made with low, average, and high atherosclerosis groups. Essential hypertension was found to accelerate the development of all types of aortic lesion, except fatty streak, as compared ...

In a London suburban general practice 87 hypertensives have been followed up for more than 15 years. These represented one third of all those (270) aged 30-59 diagnosed as being hypertensive. Females outnumbered males by 2.5: 1. Most (85 per cent), had mild or moderate high blood pressure at first ...