test if there is a difference between cases and controls - Post Questions and Discuss Biostatistics Programs and Stastistical Analysis Questions

I am new to this forum and I am hoping to find some answers. I have SNP data for two groups (Controls and Cases) and we want to answer the question is there genetic difference between the two groups?
I ran principal components on the two data sets cases and controls. I am interested in knowing if there is a significant difference between the cases and the controls, is there a test to test if there is a significant difference between the Principal components of the cases and the controls? or is there a test to test if the genetic between the cases and controls are significantly different?