Tangible Material: Caov-3 : Human Ovarian Cancer Cell Line

SK2010-069

Description

The Caov-3 cell line is a primary ovarian cancer cell line with epithelial morphology. These cells form tightly packed colonies in adherent culture. All-trans retinoic acid has been shown to suppress the growth of Caov-3 ovarian carcinoma cells in vitro. These cells express the NB/70K, CA-125, Ba-2, and Ca-1 tumor-associated antigens. The Caov-3 cells harbor a nonsense mutation in the p53 gene, and have multiple copies of the ovarian cancer oncogene PIK3CA. They are sensitive to vinblastine, cisplatin, and adriamycin. These cells fail to grow in soft agar but are tumorigenic when injected into immunocompromised mice.

Source

This cell line was established from the primary tumor of a 54-year-old Caucasian female with adenocarcinoma of the ovary.