Los Santos is a fictional city existing in the upcoming Grand Theft Auto V, based on the real-life city of Los Angeles, California. The city is portrayed in a contemporary time period, which is intended to be present-day around the date of the game's release, which is as yet unknown.

Unusually, the entire map will be open to the player right from the start of the game, rather than being restricted to a small corner or island until the game permits you to continue. This is in keeping with GTA V's philosophy of letting you do whatever you want to do, rather than being forced to do certain things at a certain time in a certain way.

Although sharing similar characteristics and landmarks as the city's appearance in Grand Theft Auto: San Andreas, the physical layout is completely remade, not being a like-for-like copy of the city's previous map.