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Pandysautonomia

July 2012

Pandysautonomia usually occurs subacutely in onset in an autoimmune context and is usually severe and affects multiple systems. Symptoms and signs include an impaired papillary light reflex, loss of sweating, orthostatic hypotension leading to dizziness and syncope on standing up or sometimes sitting up, cardiac arrhythmias may occur, gastrointestinal dysmotility such as early satiety and vomiting, small bowel pseudo-obstruction and severe constipation may occur. The patients may also complain of dry eyes and dry mouth known as "sicca symptoms." Patients may develop bladder dysfunction.