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NFL expert picks for Week 5 begin with the Arizona Cardinals vs. San Francisco 49ers on Thursday, October 6. The battle between NFC West teams takes place at 5:25 p.m. PT / 8:25 p.m. ET and is a must-win situation for both franchises. A quick look at the updated NFL standings shows that the Cardinals... Read more » NFL Expert Picks Week 5: Can Arizona Cardinals, New York Jets Bounce Back read more

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We break down the Week 5 matchup between the Arizona Cardinals and the San Francisco 49ers. The Week 5 matchup between the Arizona Cardinals and the San Francisco 49ers features two teams that are struggling. We've got the fantasy p...

Two teams struggling to escape the NFC West basement square off in primetime on Thursday night. At 1-3, the Arizona Cardinals need a Week 5 win to turn their season around. A Thursday Night Football showdown against the fellow NFC W...

When the 2016 NFL schedule was announced, Thursday's Week 5 matchup between the Arizona Cardinals and the San Francisco 49ers appeared a lopsided affair—a walk in the park for a Cardinals team expected to be among the league's best ...

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The NFC West is limping right along, and on Thursday the Arizona Cardinals will take on the San Francisco 49ers, a team they should beat. But it's been a weird season thus far. The San Francisco 49ers are 1-3 on the season, which is...