Does Gabapentin Potentiate Kratom?

People experiment with different things these days. New recipes are fun to prepare and fun to use. Same is the case with Kratom. Kratom users experiment with various drugs, supplements, and potentiators to enhance their Kratom experience.

Are you curious about the combination of Gabapentin and Kratom? Do the substances interact with each other? How will you feel after consuming Gabapentin and Kratom together?

What is Gabapentin?

Gabapentin, in other words, Neurontin is a drug that is generally taken by many for relieving the symptoms of withdrawal of opiate. Though it is being tested for its efficacy as a treatment regimen of opiate discontinuation syndrome and as a pain killer in different morbid states, it is highly used by many.

How does Gabapentin work?

Gabapentin primarily acts on the central nervous system by blocking the voltage gated Calcium ion channels. These Ca+2 channels are blocked at the α2δ subunits. It has more affinity for α2δ subunit as compared to the α2δ2 subunit of the Ca+2 Ion channels. These channels are responsible for the regulation of Ca+2 influxes when the neuronal membrane is depolarized.

How does Kratom work?

Kratom acts as a stimulant, painkiller, a mood booster and as an anxiolytic as it is composed mainly of the alkaloid mitragynine. It acts as a sedative when a larger dose is consumed. Kratom acts on the mu, delta and kappa receptors of opiates to produce its effects.