Previous GeneCards Identifiers for HLA-DOB Gene

Summaries for HLA-DOB Gene

Entrez Gene Summary for HLA-DOB Gene

HLA-DOB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DOA) and a beta chain (DOB), both anchored in the membrane. It is located in intracellular vesicles. DO suppresses peptide loading of MHC class II molecules by inhibiting HLA-DM. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008]

GeneCards Summary for HLA-DOB Gene

HLA-DOB (Major Histocompatibility Complex, Class II, DO Beta) is a Protein Coding gene.
Among its related pathways are ICos-ICosL Pathway in T-Helper Cell and CTLA4 Signaling.
GO annotations related to this gene include MHC class II protein complex binding and MHC class II receptor activity.
An important paralog of this gene is HLA-DRB1.