5 WARNINGS AND PRECAUTIONS

5.9 Concomitant use of VIMOVO with Methotrexate

Literature suggests that concomitant use of PPIs with methotrexate (primarily at high dose; see methotrexate prescribing information) may elevate...

6 ADVERSE REACTIONS

6.2 Postmarketing Experience

microsopic colitis....added

7 DRUG INTERACTIONS

7.7 Methotrexate

Case reports, published population pharmacokinetic studies, and retrospective analyses suggest that concomitant administration of PPIs and methotrexate (primarily at high dose; see methotrexate prescribing information) may elevate and prolong serum levels of methotrexate.....