Ifex

IFEX (ifosfamide) should be administered under the supervision of a qualified physician
experienced in the use of cancer chemotherapeutic agents. Urotoxic side effects,
especially hemorrhagic cystitis, as well as CNS toxicities such as confusion
and coma have been associated with the use of IFEX (ifosfamide) . When they occur, they may
require cessation of IFEX (ifosfamide) therapy. Severe myelosuppression has been reported.
(See ADVERSE REACTIONS section.)

DRUG DESCRIPTION

IFEX (ifosfamide for injection, USP) single-dose vials for constitution and
administration by intravenous infusion each contain 1 gram or 3 grams of sterile
ifosfamide. Ifosfamide is a chemotherapeutic agent chemically related to the
nitrogen mustards and a synthetic analog of cyclophosphamide. Ifosfamide is
3-(2-chloroethyl)-2-[(2-chloroethyl)amino]tetrahydro-2H1,3,2-oxazaphosphorine
2-oxide. The molecular formula is C7H15Cl2N2O2P
and its molecular weight is 261.1. Its structural formula is: Ifosfamide is
a white crystalline powder that is soluble in water.

What are the possible side effects of ifosfamide (Ifex)?

If you experience any of the following serious side effects, seek emergency medical attention or contact your doctor immediately:

What are the precautions when taking ifosfamide (Ifex)?

Before using ifosfamide, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Do not have immunizations/vaccinations without the consent of your doctor, and avoid contact with people who have recently received oral polio vaccine or flu vaccine inhaled through the nose. Wash your hands well to prevent the spread of infections.