Heart Rate, Baroreflex Sensitivity and Cardiovascular Morbidity and Mortality in the Population

Summary

The aim of the present PPS3 study is (1) to assess the determinants of the regulation of
heart rate and blood pressure variations and carotid properties (under different physiologic
stimulations) and (2) to evaluate the respective contribution of heart rate, blood pressure
variations and carotid properties to cardiovascular morbidity and mortality including sudden
death during 10 years at least in healthy considered subjects.

Description

Overall, 10 000 men and women will be recruited during two years for an extensive clinical
examination including a 2h holter ECG, a carotid doppler echo tracking, a step test, as well
as blood and DNA collections. Thereafter, the cardiovascular morbidity and mortality of the
participants will be followed up for 10 years at least.

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Medical and Biotech [MESH] Definitions

Population Surveillance

Ongoing scrutiny of a population (general population, study population, target population, etc.), generally using methods distinguished by their practicability, uniformity, and frequently their rapidity, rather than by complete accuracy.

Echocardiography, Three-dimensional

Echocardiography amplified by the addition of depth to the conventional two-dimensional ECHOCARDIOGRAPHY visualizing only the length and width of the heart. Three-dimensional ultrasound imaging was first described in 1961 but its application to echocardiography did not take place until 1974. (Mayo Clin Proc 1993;68:221-40)

Black Widow Spider

A venomous New World spider with an hourglass-shaped red mark on the abdomen.

Chi-square Distribution

A distribution in which a variable is distributed like the sum of the squares of any given independent random variable, each of which has a normal distribution with mean of zero and variance of one. The chi-square test is a statistical test based on comparison of a test statistic to a chi-square distribution. The oldest of these tests are used to detect whether two or more population distributions differ from one another.

Maximum Allowable Concentration

The maximum exposure to a biologically active physical or chemical agent that is allowed during an 8-hour period (a workday) in a population of workers, or during a 24-hour period in the general population, which does not appear to cause appreciable harm, whether immediate or delayed for any period, in the target population. (From Lewis Dictionary of Toxicology, 1st ed)

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