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Turista, Turkey Trot, Delhi Belly. By whatever name one chooses to call it, traveler’s diarrhea (TD) remains the world’s most common travel-related illness. This talk will review the relative risk of acquiring TD by geographic region and patient age, the clinical manifestations of TD’s usual bacterial (80-90%), viral (5-8%) and protozoal (~10%) culprits, as well as pre-travel counseling, traveler-initiated symptomatic treatment, and post-travel management. Through a series of case vignettes, the talk will also highlight who is at heightened risk for TD and current knowledge of post-TD sequelae, including irritable bowel syndrome, reactive arthritis, and, rarely, Guillain-Barré syndrome. This session will also discuss pros and cons of treating TD, in light of recent trends in global antibiotic resistance and growing concerns over travelers’ potential to acquire antibiotic-resistant flora, which persist long-term in their intestinal microbiome.