news

9 August 2018

InDex Pharmaceuticals updates timeline for top line results from the CONDUCT study to first half of 2019

InDex Pharmaceuticals Holding AB (publ) today announced an updated timeline for patient recruitment in the ongoing phase IIb study CONDUCT with the drug candidate cobitolimod. Top line results from the study are now expected in the first half of 2019 instead of in the fourth quarter of 2018 as previously communicated.

Cobitolimod is a new type of drug under development for the treatment of moderate to severe ulcerative colitis. The CONDUCT study is a phase IIb study that will include 215 patients with left-sided moderate to severe active ulcerative colitis at approximately 90 sites in 12 countries. The study is now approved in all the countries and hence the last clinics will be able to start enrolling patients shortly. To date 119 patients have been enrolled in the study. The aim of the dose optimisation study is that more frequent and higher doses will result in a significantly higher effect than in previous clinical studies with cobitolimod and also compared to what has been reported for products on the market and those in late stage clinical development.

“The patient recruitment for the CONDUCT study is well under way across Europe, but we have not yet reached the anticipated rate”, said Peter Zerhouni, CEO of InDex Pharmaceuticals. “Given the recruitment rate until now, we will be able to report the top line results no later than the second quarter of 2019. However, our team is working hard to increase the recruitment rate to be able to present the results earlier.”

The company will announce when the last patient has been enrolled in the study and the top line results are expected to be available within 3 months thereafter.