Testosterone Therapy Eases MetS Components in Hypogonadal Men

Abdulmaged M. Traish, MBA, PhD, of the Boston University School of Medicine, and colleagues studied 255 men aged 33-69 years with subnormal T levels (mean 9.93 nmol/L) and at least mild symptoms of testosterone deficiency assessed by the Aging Males' symptoms scale. All men received treatment with parenteral T undecanoate 1,000 mg administered at baseline and six weeks and thereafter every 12 weeks for up to 60 months.

T therapy restored physiologic T levels and resulted in reductions in total cholesterol from 281.58 to 188.12 mg/dL, the researchers reported online ahead of print in the International Journal of Clinical Practice. Low-density lipoprotein cholesterol declined from 163.79 to 109.84 mg/dL, triglycerides decreased from 276.16 to 189.78 mg/dL, and high-density lipoprotein cholesterol increased from 56.17 to 58.85 mg/dL). All of the changes were statistically significant.