Multi-dot it's a dps increase in any situation, eg: Stone Guards, Spirit Kings, Elegon. On Will of Emperor if you multi-dot everything and don't let dots fade from bosses, you'll do around 130-140k on 25 men. Garalon, Meljarak, Amber-Shaper, Shekzeer, Sha of Fear.

Like you can see most of the fights on this tier are multi-dot fights.