Halicloic Acids A and B Isolated from the Marine Sponge Haliclona sp. Collected in the Philippines Inhibit Indoleamine 2,3-Dioxygenase.

MedLine Citation:

PMID:
22873824
Owner:
NLM
Status:
Publisher

Abstract/OtherAbstract:

Two new merohexaprenoids, halicloic acids A (1) and B (2), have been isolated from the marine sponge Haliclona (Halichoclona) sp. collected in the Philippines. The glycolic acids 1 and 2 slowly decomposed during acquisition of NMR data to aldehydes 3 and 4, respectively, via an oxidative decarboxylation. Halicloic acid B (2) has the new rearranged "haliclane" meroterpenoid carbon skeleton. The halicloic acids 1 and 2 are indoleamine 2,3-dioxygenase inhibitors that are significantly more active than the decomposition products 3 and 4.