Louisville's offense is averaging 615 yards a game, fifth in the nation, but Clemson's defense ranks No. 2, allowing under 150 yards a game. The two teams have played close games in each of the past three seasons, with Clemson winning all.

The only other game matching two Top 25 teams has No. 23 Tennessee at No. 24 Florida at 3:30 p.m. on CBS.