“I’ve been
getting very cross with articles – including one I read in HTU – that emphasise how people with HIV are going to die 10 to 15
years younger,” says John, 70.

“My recipe
for long life is always to think positive and to refuse to be a victim of HIV,”
he adds.

John is
referring to the oft-cited assertion that people with HIV age 10 to 15 years in advance of
other people2 – in other words that a 60 year-old with HIV has a
biological age of 75.

Is this
inevitable? Or does it involve factors we can control?

Will we age quicker?

People
diagnosed in the last few years who start antiretroviral therapy (ART) at a
sufficiently high CD4 count, and stay on it, are likely to have a normal
lifespan. One recent UK study found that a non-smoking, 30-year-old gay man,
whose HIV is diagnosed promptly, could expect to live until he is 78, the same
age as the average UK male.3

This
doesn’t hold for everyone with HIV, though. Another recent study of life
expectancy in people on ART found that, compared to the general UK population,
life expectancy at age 20 was 18.3 years less for men and 11.4 years less for
women.4 That means that, on average, life expectancy for someone
aged 20 would be 59 if a man and 71 if a woman. Why the disagreement between
studies?

On the one
hand, excluding AIDS-defining illnesses – which now cause only a small minority
of deaths in people taking ART5 – people with HIV also have higher
rates of many other illnesses. They have about twice as much cardiovascular
disease and 60% more heart attacks than the general population,6 are
much more likely to get bacterial pneumonia7 and are at raised risks
of many cancers.

On the
other hand, this life expectancy deficit is overwhelmingly concentrated in
people who are diagnosed late, and most of the deaths that bring the average
life expectancy down occur in the first year after diagnosis.8 Also,
life expectancy is an estimate of how long we might expect to live given
current conditions and no further medical advances.

Anyway, who
says you are average? If you’re reading HTU,
you’re probably not. Half of HTU’s
readers are over 50 – over twice the proportion in the general HIV-positive
population. If you’ve already got that far, your life expectancy will now
extend beyond 59 – and a lot of you will have reached that age already.

Medical issues in older people with HIV

Dr Mike
Youle is an HIV doctor with a particular interest in the health of older
people.

“Some
changes are inevitable natural processes,” he says. “Take high blood pressure.
It’s not good for you, but given that it rises in virtually everyone as they
age, is it an ‘illness’ or just a consequence of ageing that develops at
different rates in different people?”

He thinks a
lot of the observed deficit in life expectancy and overall health is due to the
legacy of untreated AIDS in the pre-ART era.

“A person
who’s had zero T-cells at some point in their life may never repair the gaps in
their immune system,” he says. “Their vulnerability to illness may be very
different from someone who was treated soon after infection.” This is borne out
by studies that show that the likelihood of developing cancer9 or
HIV-related brain impairment10 is related much more strongly to a
person’s lowest-ever CD4 count than to their current one. “There is also some
evidence HIV directly ages cells,” he adds.

So if we
take ART, we should stop ageing faster? No, unfortunately. The one class of HIV
drugs that virtually everyone on ART has taken are the NRTIs – the nucleoside
reverse transcriptase inhibitors. NRTIs prevent HIV’s DNA copying its genes. To
a lesser extent, they also interfere with our own genes, especially those in
our mitochondria.

Mitochondria
are little capsules inside our cells that supply energy. Their genes are
vulnerable to drug damage because they lack the error-correction mechanisms of
the DNA in our cell nuclei. We’ve largely stopped using the drugs most toxic to
mitochondrial DNA – ddI, ddC, d4T and, to a lesser extent, AZT – but the damage
may be persistent, and all NRTIs may cause some mitochondrial toxicity.

What to do about it

By now, you
may be feeling anxious. But there are things you can do to reduce the
likelihood of age-related conditions.

“Exercise
and diet are key,” says Mike. “In many ways, treated HIV and type 2 diabetes
resemble each other. They can be exacerbated by an unhealthy lifestyle, but the
burden of disease they impose can be reversed by adopting a healthier one.”

Our
capacity for aerobic exercise is reduced when our mitochondria are damaged,11
but, on the other hand, exercise can actually gee-up slow mitochondria,12
at least in people with diabetes.

These are
not the only risk factors that are under our control. One study in 2009,13
and others since, have estimated that the disease burden in people with HIV
with undetectable viral loads could be halved if people maintained a healthy
weight; controlled their carbohydrate intake and avoided diabetes; had their
blood pressure monitored and took medication if it was too high; avoided
hepatitis C and were vaccinated against hepatitis B; and stopped smoking. These
measures would make even more difference in the over-50s.

So that’s
what your doctor would prescribe. But what can you do if you’re the patient?

Always double-check what the doctors say

David is
67, a retired antiques dealer. He has had health scares, and he thinks that
people like him need to monitor their health more closely than HIV-negative
people might – and to learn how to get what they want out of the NHS.

“I do
believe that people with HIV may present with diseases of ageing in advance of
others: I think our health is often a little ‘off-colour’, he says. “I also
think however that older people with HIV, far from being vigilant, may present
with symptoms later, because they think, ‘It’s just HIV’.”

In his
case, anal screening had established he had AIN stage 2 – anal intraepithelial
neoplasia, a change in the cells lining the anus that may, if left unchecked,
develop into cancer.

“I felt
things weren’t right down there,” he says. “The pathologist scheduled me for a
biopsy but told no one he was on leave and further appointments kept being
cancelled. Eventually, when I insisted on an appointment and was seen, they
told me I’d have to have immediate surgery and radio- and chemotherapy.

“I phoned
one of the HIV consultants who in turn got me to talk to a cancer specialist at
another hospital who said ‘Don’t be ridiculous, we can manage this’.” David
didn’t have to have surgery.

Conversely,
he says, he’s sometimes had to insist on medical intervention. “I’ve had skin
cancer before and a few years ago I was getting a one-sided headache and a
feeling I had persistent sunburn. I took it to the on-call registrar at my HIV
clinic and she said ‘Yes, it’s basal cell carcinoma [the most common form of
skin cancer], and we’ll see you in two months’. I said ‘If this is cancer, get
it out of me now!’.”

The key, he
says, is “always to get a second opinion”. He doesn’t mean by this to set
doctors against each other – unless necessary – but, for instance, to get
checked out regularly by your GP too.

Use your GP

“I see my
GP practice every three months or so. You can nominate which doctor you want to
see. GPs will do things that HIV clinics don’t – such as automatically check
your blood pressure.”

Mike Youle
agrees with this. “I took a long time to engage with GPs, but HIV clinics won’t
be able to do everything for older HIV patients.”

He also
thinks all HIV clinics should be setting up age clinics, along the lines of London’s Chelsea and Westminster Hospital, which already runs a
specialist age and HIV clinic.

David says:
“There should be a standard set of good-practice guidelines on what to do for
older HIV patients, with a user-friendly version for patients. And there should
be a special appointment at the HIV clinic when someone is 50, and maybe every
five to ten years thereafter, to do a comprehensive ‘MOT’ and check for
anything likely to cause trouble.”

To be
really comprehensive, a health MOT would also need to include psychological and
cognitive tests. David thinks the psychological and socioeconomic situation of
many older people with HIV is crucial to their health.

Depression, anxiety and ageing

Studies
show that there is an association between high cholesterol and Alzheimer’s
disease,14 and that diabetes and Alzheimer’s may be caused by
similar metabolic disturbances, to which HIV may add its own kind of
impairment. But David feels a lot of ill-health has social and psychological
causes. “There are a lot of isolated, mildly depressed older people out there –
especially men – who don’t look after themselves and for whom life has little
to offer.”

There’s
even research that shows that depression and anxiety may have a direct effect
on genes that control ageing - and levels of depression in older people with
HIV are scandalously high.

Recently, a
study in San Diego, California, compared old with young and HIV positive with
negative, in a group of 179 locals.15 It got them to complete
separate questionnaires on how easy they found it to deal with tasks of daily
life, and assessed their overall emotional quality of life and their burden of
diseases common in older people.

It found
that daily functioning was worse in people with HIV, especially older people,
and that HIV had a stronger effect on ability to carry out daily tasks than
age. But the only factor in the HIV-positive over-50s that predicted poorer
functioning in every domain, especially compared with HIV-positive under-40s,
was major depressive disorder, sometimes called ‘clinical depression’.

That means
depression strong enough to stop you getting out of bed. The prevalence of
current major depression in the HIV-negative participants, regardless of age,
was 2.3%. In HIV-positive people over 50 it was ten times as common – 24.5%.

This is of
particular concern because it does not reflect the experience of most people as
they age. Older people are generally happier people. In 2010, a study in New
York asked nearly 350,000 18- to 85-year olds how stressed, angry, worried, sad
or happy they were.16 The peak age for being happy was 70, and the
peak age for overall wellbeing was 85; perhaps the only reason it wasn’t older
is because that’s where the survey stopped. Other research shows that the
patterns holds true for western and eastern Europe, Latin
America and Asia.17

There is
also research – among HIV-negative people – that indicates a direct link
between emotional upset and length of life.18 Not because it makes
people smoke or drink or kill themselves, but because stress directly harms
genetic material that protects us against the effects of ageing.

Given
levels of depression as high as those seen in the San Diego study, it could mean that a large
portion of the reduced life expectancy seen in people with HIV can be directly
laid at the door of isolation, stigma, shame and worry. And the key to a longer
life might be to make friends, stay proud, fight stigma and stay calm.

A sense of belonging

Mike Youle
says: “It’s a cultural thing, operating at several levels. One is that older
people feel on the shelf generally: the best thing you can do for them is offer
the chance to work. Secondly, there’s not been a place for retired men to go
to. The Women’s Royal Voluntary Service is now actually doing some work with
older single men and how to engage them... Thirdly, there’s never been any
model for how you age gracefully as a gay man, not even in the pre-HIV days.”

One thing
he’d like to see, he says, “is one of the best things I think the Terrence
Higgins Trust ever did – buddying. This time, not for people with AIDS, but for
older people with HIV.”

One recipe: friends, dancing and good food

John might
be an example to follow. The 70-year-old retired lecturer in earth sciences has
regrets, in particular the loss of his beloved partner of 25 years, Nick, who
died of AIDS in 1993, and that he has not found another to be with in later
life.

In other
ways, however, his life is very full. “I love London and would not want to move out of it,
even though most of my friends have,” he says. But he maintains a group of
friends, gay and straight, men and women, and visits one nearly every weekend.

He also has
his weekly exercise workout. “Every Thursday I go to Heaven gay disco in London and dance for a
couple of hours. It keeps me fit and I’m surrounded by 20 year-olds who are
nice and friendly; I have been with younger people most of my working life and
I’m sure this helps me keep a youthful outlook.” Having said that, realising
dancing didn’t exercise his upper body, he’s just bought a set of dumbbells.

He is very
concerned about his diet, not in a faddish way, though he does worry about the
constantly changing dietary advice. “But I do always cook myself a proper meal
in the evening and will have a large glass of single malt Scotch whisky – never
more – to speed me along while I’m doing it.”

Like David,
he believes in the value of getting second opinions and questioning medical
decisions. He has reason to: he has multi-class drug resistance and
lipodystrophy, and had lactic acidosis that nearly killed him, partly because
doctors attributed all the acute symptoms he was suffering from to one drug,
nevirapine, when in fact most were caused by another, ddI. John’s health picked
up when he decided to follow his original “wonderful” HIV doctor to his new clinic.

“Doctors,
and especially GPs, don’t pick things up,” he says. “You have to push things in
front of them”. Like David, he sees a GP practice where there are two nominated
doctors he chooses to see.

Also like
David, he’s had more problems with inexperienced staff. “I went [to my HIV
clinic] and my regular doctor wasn’t there. I saw a registrar who said ‘Your
results are fine’, implying I could leave, but when I asked what my viral load
actually was, it was 220. I said ‘Excuse me, it’s supposed to be under 50!’ and
demanded another test. This was in fact the first sign of my drugs failing, as
subsequent tests showed higher viral loads. I’m now on a new regimen which I’m
pleased to say is working well.”

He keeps
himself mentally alert, saying “I read The Economist rather than sit there
doing Sudoku.

“I think
staying positive and surrounding yourself with people who like you is the key,”
he concludes, “and especially retaining an interest in helping others. Some
older people get very self-absorbed. I think every time you take an interest in
someone else, it prolongs your own life. Ask not what they can do for older
people like you, but what an older person like you can do for them.”

Issue 213: Autumn 2012

This content was checked for accuracy at the time it was written. It may have been superseded by more recent developments. NAM recommends checking whether this is the most current information when making decisions that may affect your health.

NAM’s information is intended to support, rather than replace, consultation with a healthcare professional. Talk to your doctor or another member of your healthcare team for advice tailored to your situation.