In 2374, when USS Voyager made contact with Starfleet Command after years alone in the Delta Quadrant, they transmitted hundreds of kiloquads of data home about the region they had traversed. (VOY: "Message in a Bottle") In return, utilizing the same alien sensor relay network, Starfleet Command transmitted a large amount of encrypted data intended to reach USS Voyager but due to issues using such ancient alien technology, was badly degraded in transit. Arturis was able to reconstruct over 68 kiloquads of information, however, much of it was still garbled. (VOY: "Hope and Fear")

Whether the "garbled" portion of the data was a different subset of the entire message sent by Starfleet or a subset of the 68 kiloquads Arturis helped reconstruct is unclear.

Before being transported through a compressed data stream to the MIDAS array in the Alpha Quadrant from the USS Voyager in the Delta Quadrant, the Emergency Medical Hologram had to leave 12 megaquads behind to fit the bandwidth of the transmission. (VOY: "Life Line")

After a long ordeal while in contact with a being known only as "the distortion ring" B'Elanna noted that they had over twenty million gigaquads of new information input into the ship's computer. (VOY: "Twisted")

The terms quads and kiloquads in TNG were used in a manner consistent with the system defined in the Technical Manual. However, by the time Voyager was airing, they started using extremely large numbers that lacked internal consistency, such as "billions of gigaquads" and "billions of teraquads." If these are accurate, USS Voyager's computers are more advanced and have a capacity that is orders of magnitude greater than the ones just seven years earlier in TNG.

Writers and advisers deliberately used prefixes used with bytes in modern day notation (mirroring kilobyte, megabyte, gigabyte, and terabyte). The terminology "quad" was used to detract from comparisons possible with modern-day computing power, since reality frequently outstrips fiction when it comes to computer science. Current capabilities are orders of magnitude greater than what scientists expected them to be only 20-30 years ago, with capacities and speeds roughly doubling every two years as per Moore's Law.