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So I got 4-AP compounded and tested it at 10mg x 4 times a day dose (later went down to 5mg 4x a day due to nausea), after which, as a C4-incomplete I noticed:

- greatly reduced spasticity allowing noticably faster heel-to-toe walking- sweating for the first time down my back -> a marked improvement in sensation- increased firmess through the core- better hand dexterity and alleviation of shoulder tightness/pain

These are similar benefits to what wumedical stories say.

I've then concluded then that anybody contemplating stem cell therapy should consider trying 4-AP first to gauge how much remyelination potential exists, along with functional gains obtained. 4-AP is a lot cheaper than say the US$25k Wumedical stem cell therapy though of course when you're not on it, the benefit is gone.

Asteria's AST-OPC1 stem cell treatment above and below the injury site is about as good as it gets. Though that's still at a clinical trial phase .

4-AP is available from your local compounding pharmacy with a prescription. Looking at 5mg every 2-4 hours dosage. I found 10mg in such doses caused nausea. In Australia, I was paying AU$100 for 100 tablets. A bit expensive for what used to be a bird repellent, so I found a significantly cheaper source that even stocks the better 4-AP-3-MeOH, though that form costs 3.33 times more than 4-AP.
https://www.mod4all.com/zencart/index.php?main_page=index&cPath=2

I'm yet to try 4-AP-3-MeOH but the "requires 1/10 dose of 4-AP" literature of Dr. Shi is attracting me to do so.

Came across that a week or two ago. I've been taking 4-ap for about two years now. I have a high level of function, full time walking, semi professional cyclist, after being diagnosed as a complete injury 13 years ago. In theory, I'd thought that 4-ap would possible cause mylein to regrow, slow rate, but would be possible. What I've seen in my recovery tells me it has happened.

I took Ampyra for 3 years, then I had a spinal stimulator surgically installed. I let the prescription run out (wrong) and I have some older stuff here that I had compounded a while ago. My best walking was with the 4-AP and the stimulator. I decided do to the cost to just used the stimulator, lately I have been turning it down more and more. I feel it if it isn?t even on, it?s been a year since I had this done. I am going to get back on the 4-AP and see what?s going on now. As of now, I can feel the cold breeze on my ankle from time to time and things are just generally weird, going to go back to San Diego where I had it done for a tune up, as I know what and where I need more function, it?s been just a bad and hectic year for me on other sides, and now I have a plan. Plus I found out I have gout, and no valves in my internal blood veins so I have this wonderful water problem, the key is to keep moving at all costs, and I'm no spring chicken, stubborn to say the least.

Came across that a week or two ago. I've been taking 4-ap for about two years now. I have a high level of function, full time walking, semi professional cyclist, after being diagnosed as a complete injury 13 years ago. In theory, I'd thought that 4-ap would possible cause mylein to regrow, slow rate, but would be possible. What I've seen in my recovery tells me it has happened.

I took Ampyra for 3 years, then I had a spinal stimulator surgically installed. I let the prescription run out (wrong) and I have some older stuff here that I had compounded a while ago. My best walking was with the 4-AP and the stimulator. I decided do to the cost to just used the stimulator, lately I have been turning it down more and more. I feel it if it isn?t even on, it?s been a year since I had this done. I am going to get back on the 4-AP and see what?s going on now. As of now, I can feel the cold breeze on my ankle from time to time and things are just generally weird, going to go back to San Diego where I had it done for a tune up, as I know what and where I need more function, it?s been just a bad and hectic year for me on other sides, and now I have a plan. Plus I found out I have gout, and no valves in my internal blood veins so I have this wonderful water problem, the key is to keep moving at all costs, and I'm no spring chicken, stubborn to say the least.

Glad to hear you're staying with the program and still working forward. Best of luck on your return trip to San Diego!

Thanks! I have. It's been a VERY long road. I've explored pretty much every road out there. I am still chasing what most would call a "cure", for me nothing is enough. Which I've often called a curse and a blessing. it's what has gotten me this far, but keeps me up most nights.