Abstract

Backround Rapid identification of diverse fusion genes with involvement of PDGFRA or PDGFRB in eosinophilia-associated myeloproliferative neoplasms (Eos-MPN) is essential for adequate clinical management but is complicated by the multitude and heterogeneity of partner genes and breakpoints. Design and Methods. We established generic quantitative RT-PCR assays (RQ-PCR) to detect overexpression of 3′-regions of PDGFRA or PDGFRB as a possible indicator of an underlying fusion.