Ashton Hewitt, Rhodri Jones and Aaron Wainwright have been called up, with Adams, Francis and Charteris not released by their Aviva Premiership sides — Worcester Warriors, Exeter Chiefs and Bath respectively — because the opening match of Wales' tour falls outside the international window.

Premier Rugby Limited, the umbrella organisation that deals with the interests of England's top sides, has an agreement with its clubs that only English players should be released for out of window international activity.

Although the trio would effectively be available for the rest of the tour, Gatland's coaching staff has decided to replace them as they'd miss a large chunk of training and preparation.

It means a big opportunity for uncapped Dragons duo Hewitt and Wainwright, as well as Ospreys prop Jones.

With back-rower Wainwright called into the setup to seemingly replace the crocked Navidi, it looks as though Bath veteran Charteris hasn't been replaced.

The first match of the tour against South Africa, in Washington on June 2 is outside World Rugby's international window.

Wales then travel to Argentina for two further Tests on June 9 and 16, which the trio will not play in.

English-based players George North and Ross Moriarty won't be affected as they are both on the move to Welsh sides this summer.

George North and Ross Moriarty

Wales head coach Gatland said:"We are really disappointed that Josh, Tomas and Luke have to miss out on the opportunity to tour with Wales and play international rugby this summer.

"It was a great opportunity for them to play for their country, press their claim in an important year and it is a shame supporters will not get to see them in the red of Wales.

"The situation is very clear for players playing in England going forward and heading into a RWC year.

"With the players unavailable to link up with the squad until the week of our second test match we have had to replace them in the squad."

Warren Gatland (Image: Huw Evans Picture Agency)

On Navidi, Gatland added: "It is a blow for Josh to pick up the injury and miss out on the summer. He has been an important player for us over recent campaigns and has really impressed"