Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )

Length:

57

Sequences:

344

Seq/Len:

6.04

HH_delta:

0.855 (20Jul13)

GREMLIN Results:
Residue pairs sorted by strength in covariance:Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

i

j

Raw Score

Scaled Score

4_A

7_L

0.62462

3.605

6_G

53_L

0.44798

2.586

24_R

35_D

0.35578

2.053

17_F

46_M

0.34649

2.000

16_P

23_W

0.33086

1.910

15_L

45_S

0.24043

1.388

44_V

48_I

0.22015

1.271

51_V

55_L

0.21927

1.266

28_R

32_Q

0.21224

1.225

19_A

30_L

0.20954

1.209

33_L

41_I

0.20743

1.197

4_A

24_R

0.20512

1.184

25_R

28_R

0.20325

1.173

14_L

46_M

0.2032

1.173

47_V

55_L

0.20287

1.171

36_R

40_R

0.19772

1.141

17_F

23_W

0.19734

1.139

25_R

29_Q

0.19135

1.104

29_Q

37_Q

0.19067

1.101

37_Q

40_R

0.19011

1.097

50_L

53_L

0.18918

1.092

4_A

8_V

0.18463

1.066

18_L

22_R

0.18455

1.065

14_L

41_I

0.18273

1.055

21_E

35_D

0.18094

1.044

10_I

16_P

0.17762

1.025

23_W

27_L

0.17712

1.022

22_R

26_M

0.1738

1.003

24_R

38_L

0.17021

0.982

41_I

44_V

0.16936

0.978

28_R

31_A

0.16517

0.953

27_L

31_A

0.16489

0.952

6_G

16_P

0.16432

0.948

5_L

21_E

0.16356

0.944

15_L

23_W

0.16254

0.938

13_G

20_P

0.16224

0.936

22_R

25_R

0.15979

0.922

38_L

42_G

0.159

0.918

40_R

55_L

0.15587

0.900

41_I

48_I

0.15554

0.898

12_E

20_P

0.15515

0.895

28_R

44_V

0.15389

0.888

2_L

52_L

0.15356

0.886

15_L

30_L

0.15115

0.872

24_R

55_L

0.14888

0.859

14_L

24_R

0.14837

0.856

32_Q

54_W

0.14604

0.843

44_V

55_L

0.1453

0.839

17_F

53_L

0.14485

0.836

34_P

40_R

0.14196

0.819

6_G

27_L

0.14004

0.808

16_P

53_L

0.14003

0.808

10_I

49_G

0.13915

0.803

18_L

39_R

0.13838

0.799

48_I

54_W

0.13656

0.788

39_R

50_L

0.13603

0.785

20_P

24_R

0.13585

0.784

10_I

21_E

0.13572

0.783

40_R

44_V

0.13478

0.778

27_L

40_R

0.13413

0.774

40_R

47_V

0.13373

0.772

6_G

50_L

0.13302

0.768

14_L

26_M

0.13148

0.759

3_A

9_L

0.13084

0.755

21_E

38_L

0.13074

0.755

11_I

25_R

0.13042

0.753

27_L

33_L

0.1303

0.752

2_L

16_P

0.12992

0.750

47_V

51_V

0.12895

0.744

5_L

56_V

0.12869

0.743

28_R

52_L

0.12864

0.742

14_L

30_L

0.12727

0.735

9_L

45_S

0.12623

0.729

14_L

18_L

0.12559

0.725

14_L

36_R

0.1248

0.720

12_E

39_R

0.12452

0.719

15_L

26_M

0.12412

0.716

3_A

56_V

0.12316

0.711

6_G

43_L

0.12293

0.710

11_I

19_A

0.12201

0.704

13_G

42_G

0.12139

0.701

17_F

52_L

0.12129

0.700

19_A

23_W

0.12098

0.698

Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.