Why Visit: Just three years ago, this bread factory stood vacant. But now the early 1900s building is home to a thriving collection of businesses, including West Sixth Brewing Company, Smithtown Seafood, FoodChain, Magic Beans Coffee Roasters, and Bluegrass Distillers (plus a few ventures selling non-edible wares). "The coolest thing is that the restaurant, Smithtown Seafood, serves beer from West Sixth, as well as tilapia and greens grown in the nonprofit FoodChain's indoor aquaponics system," says Rice. How's that for a community effort?