Your chance of getting the energy you want with two dice is 67%ish and your chance of getting a sidekick is about 33% the risk is half the reward. More than that, and your risk gets too high. But honestly, it's statistics, it doesn't matter how many dice you role there's still a chance you get something bad. I do think you minimize risk of characters the fewer dice you roll, and the chance of getting the energy you want is relatively common in a small amount of dice. But, as I mentioned in the article, anything could happen and it's better to have alternatives planned for than to try and reroll for a perfect roll.

I am quite surprised there aren't opening guides with all the alternatives listed at least for certain teams like Guy rush or Hulk Polymorph control.
It takes some time to figure out and knowledge of possible openings can improve your decisions and sped of play significantly.