Assistant

DF/HCC Program Affiliation

Research Abstract

My primary research interest is to dissect the PI 3-K/Akt signaling pathway in cancer progression using biochemical, genomic and bioinformatics approaches. The discovery that the Akt signaling cascade is one of the most frequently mutated pathways in cancer, and the considerable efforts in developing Akt inhibitors as anti-cancer therapeutics, makes this an exciting time for basic and translational research relating to this pathway. A major research focus in my laboratory is the identification of distinct functions of Akt isoforms in different tumor contexts. We aim at discovering novel Akt isoform-specific targets, with an emphasis on their implications in personalized targeted therapy.