The executives of Osborn Industries were later visited by Peter Parker, who confronted Norman Osborn, but then escaped as soon as the police arrived on the scene.[10]
A short time later, Osborn performed here the Gathering of Five ritual with Madame Web, Matt Franklin, Morris Maxwell and Override.[11]
Osborn turned insanely mad and was later found here clad in his Green Goblin costume by Spider-Man.[12]
A while later, the Osborn security was attacked by Shadrac.[13]

A short time later, the Osborn Chemical Manhattan plant was attacked by the Flaming Sword, but the terrorists were eventually defeated by the Avengers.[14]

On Earth-TRN562, Oscorp Lab was the base of Osborn Private Science Institution. With the pretext of wanting to work with the Academy geniuses, Headmaster Norman Osborn decided to move the campus close to the Avengers Academy. His protégés Doctor Octopus, and the Lizard advised him not to do that, telling him doing that would potentially jeopardize their secret plan.
Worried about Spider-Man possibly interfering with their plans again, they recreated Spider-Man's webs in this labs, and committed various crimes around New York using it, making it look like Spider-Man was the one committing the crimes.