Mind control is any method of influencing the actions of another sentient being. It can range from absolute control, where the subject has no will of his or her own, to more subtle forms, such as suggestion. Some forms of mind control leave the victim aware that he behaved against his will, while others leave him believing that his actions were his own. Mind control can be performed psionically or mechanically. Some Federation species, notably Vulcans, are able to perform very limited forms of mind control, more akin to strong suggestions. Mechanical mind control is beyond the generally available technology of the 24th century (but see neural neutralizer for an example of a 23rd century approach).

The aliens Sylvia and Korob, encountered in 2267 on Pyris VII, employed a device called the transmuter to amplify their own will. Among other feats, this permitted them to enthrall visitors telepathically. Subjects were aware of who they were and their surroundings, but were entirely unable to resist the aliens' will. (TOS: "Catspaw")

While restrained, Spock caused a native of Omega IV to operate his communicator, summoning help for the landing party. (TOS: "The Omega Glory")

In 2374, Chakotay was subject to a mind control technique by the Vori that would program him to act against their enemies, the Kradin, by convincing him that they were more malevolent and dangerous than they were. (VOY: "Nemesis")

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