Are there be frames that don't fall into the standard, bipedal humanoid design (Excluding Ijad frames)? I mean human-designed frames that took after animals, like dogs or lions? A good example of what I mean is Wolfenstein's Panzerhund. Sure, it's a robot and not piloted by a human, but still. Panzerhund image:

"Frame" is left as an intentionally vague term so you can go imagine what you'd like. Most of the canon models mimic their pilot's physical motions, and so they are ergonomically identical, but others are piloted in cockpits like traditional mechs. Do whatever.