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Prescription Advice

Preclinical and clinical data suggest THC, CBD and to a lesser extend CBG may be therapeutic in the treatment of pain.

Given the nature of the disorder, oral or sublingual application may be beneficial, but depending on the origin of the pain topical application to the skin may also work without the risk of psychoactive side-effects. Also smoking/inhalation is an option.

For topical use, apply oil or extract until the symptoms subside.

For inhalation, use until the symptoms subside or side-effects become intolerable.

Please note that, while based on preclinical and/or clinical research, this prescription advice is solely intended as a guideline to help physicians determine the right prescription. We intend to continuously update our prescription advice based on patient and/or expert feedback. If you have information that this prescription advice is inaccurate, incomplete or outdated please contact ushere.

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Literature Discussion

In a mouse study, the endocannabinoid system was found to be required for the analgesic action of acetaminophen (paracetamol); FAAH breaks down acetaminophen to AM404 (first identified as synthetic Cannabinoid but also displaying endocannabinoid activity), which in turn blocks re-uptake of Anandamide (Mallet et al., 2008).

In mice, inhibition of opioid-degrading enzymes potentiates the analgesic effect of THC, suggesting cross talk or synergy between the opioid- and endocannabinoid systems in pain management (Reche et al., 1998).

In humans, on the other hand, THC was found not so much to enhance the analgesic effect of Morphine but to inhibit the experienced discomfort that is normally associated with pain (Roberts et al., 2006).

This would suggest that cannabinoids do no necessarily block pain sensation but rather dissociate negative emotions from the experienced pain.

In a rat model, THC was found to suppress muscle pain via activation of CB1 (Bagüés et al., 2014).

Several synthetic CB2 agonists have been patented for their analgesic properties, indicating a strong role for CB2 in pain management (Murineddu et al., 2012).

TRP receptors (TRPV1-4, TRPA1, TRPM8) are classically known for their role in pain sensation.

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