Recently went on Synthroid, due to sluggish thyroid. I also, on my own, decided to go to the health food store and purchase Raw Adrenal(165 mg) & Pituitary supplements (80 mg) These are made in New Zealand and are bovine products. I take the Synthroid on an empty stomach, in the morning. Half an hour later, I then take, with foodothie, 1 adrenal and 1 pituitary pill. I feel great and I feel like I am bouncing off the walls. But by 2:00 p.m., I feel very fatigued, have trouble concentrating and want to sleep at my computer. This is not typical of me. Since I have been taking these (about 30 days), I have gained over 20 pounds. Some of that was holiday gain, but not all of it. I am not really eating out of the ordinary to where I am able to maintain. I am wondering if the adrenal and pituitary supplements would somehow cause weight gain? I researched this on the internet and I am not finding very much information on the relation of hormones and weight gain. Can you help me with this?

I very much doubt the addition of the supplements, espeically those specific supplements, are having a paradoxical weight-gain effect. However, I do wonder if your Synthroid levels are correct. Have they been checked regularly since you started the therapy? Early on it's sometimes a delicate balancing act to get this just right, and if it's too little, even though the supplements may be working for you like caffeine, your overall metabolism would still lag and there could be weight gain. There's little else I can think of to explain this. Hopefully you've had or will soon have a follow up level check to be certain it doesn't need to be raised. And if it does, you may find you don't need (or even want) the supplements.