This article offers a complete revision of botulinic toxins, which are the mosttoxic among the organic compounds. Scarcely 100Kg equitably distributed arerequired to kill the whole mankind, and as a consequence its use has been sugges-ted in conventional war or terrorisms. The molecular biology and the action me-chanisms of the botulinic toxins are also described in this article.In spite of the dangers, these toxins could be useful in therapeutic treatment of distonies, such as those from larynx, acalasy, blepharospasm, multiple sclerosis,hemifacial spasms, and on the other hand, for tic and wrinkles treatments.