5′-Thiol Modifiers are phosphoramidites used to produce a functional thiol group on the 5′-terminus of oligonucleotides. Thiol modification allows attachment of a variety of products, such as fluorescent dyes, maleimide compounds, biotins and proteins. The trytyl group is used to protect the thiol and is not acid labile. The trityl protecting group which is lipophilic allows a trityl-on reversed-phase purification. A final deblocking of the oligonucleotide is accomplished by oxidation with silver nitrate and dithiothreitol (DTT).

Technical Information

Packing size: 0.1g, 1g, Bulk

HS Code: 382200

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