The Flintstones is, and STILL is, probably the second most brilliantly-written sitcom of the entire 60's. (At least, the first three seasons, before baby Pebbles came on, and the marketing-kissups took over.)
And that's live or cartoon, second only to the Dick Van Dyke Show, and just ahead of The Addams Family.

Like the Simpsons, a mix of snarky social satire taken to sarcastically silly extremes, only without the angry bile, and more like the surreal wiseguy silliness of Jack Benny's old radio show:

TV Announcer: "Tonight's story of a husband who runs away after his twelfth child is born, is called 'Have Enough--Will Travel'. But first, a word from our sponsor:"
Sponsor: "Ladies and gentlemen, (sad violin music) this program is costing me a fortune, so please...buy my product! "

Was gonna say Family Guy, but someone mentioned Simpsons. I haven't had the chance to watch much of the Simpsons though; I have seen the movie and a couple of random episodes, and they were amazing xD, so I'm not sure which I'd rather pick. xD