The commemoration of these four Roman saints is made by the Church on 12 May, in common, and all four are named in the Proper of the Mass as martyrs. The old Roman lists, of the fifth century, and which passed over into the Martyrologium Hiernoymianum, contain the names of the two martyrs Nereus and Achilleus, whose grave was in the Catacomb of Domitilla on the Via Ardeatina; in the same calendar was found the name of Saint Pancratius, whose body rested in a catacomb on the Via Aurelia. The notice in the more complete version given by the Berne Codex, runs as follows: “IIII id. Maii, Romae in coemeterio Praetextati natale Nerei et Achillei fratrum, et natale sci. Pancrati via Aurelia miliario secundo” (On 12 May at Rome in the cemetery of Praetextatus [an evident error for Domitilla] the natal day of Nereus and Achilleus, and the natal day of Saint Pancratius, on the Aurelian Way at the second milestone”; ed. de Rossi-Duchesne, Acta SS., Nov., II, [59]). In the invocation of the Mass for their feast, in the “Sacramentarium Gelasianum”, the names of Nereus and Achilleus alone are mentioned, and this is because only their invocation in the Mass was entered in the collection, the feast of Saint Pancratius being celebrated in the church built over his grave on the Via Aurelia. In the Mass of his festival, the formula of which is unknown to us, his name, without doubt, was alone mentioned. In the fourth and following centuries there was celebrated on 12 May in both places, at the grave of Saints Nereus and Achilleus on the Via Ardeatina, and at that of Saint Pancratius on the Via Aurelia, a special votive Mass. The Itineraries of the graves of the Roman martyrs, written in the seventh century, are unanimous in their indication of the resting-place of these saints. The church which was erected in the fourth century over the grave of Saint Pancratius, stands today in somewhat altered style. The legend describing the martyrdom of the saint is of later origin, and not reliable historically; it is probable that he was put to death in the persecution of Valerian (257-58) or in that of Diocletian (304-06).

The church built over the grave of Saints Nereus and Achilleus in the Via Ardeatina, is of the latter part of the fourth century; it is a three-naved basilica, and was discovered by de Rossi in the Catacomb of Domitilla. Amongst the numerous objects found in the ruins were two pillars which had supported the giborium ornamented with sculptures representing the death of the two saints by decapitation; one of these pillars is perfectly preserved, and the name of Achilleus is carved on it. There was also found a large fragment of a marble slab, with an inscription composed by Pope Damasus, the text of which is well-known from an ancient copy. This oldest historical mention of the two saints tells how Nereus and Achilleus as soldiers were obedient to the tyrant, but suddenly being converted to Christianity, joyfully resigned their commission, and did the martyr’s death; as to the date of their glorious confession we can make no inference. The acts of these martyrs, legendary even to a romantic degree, have no historical value for their life and death; they bring no fewer than thirteen different Roman martyrs into relation, amongst them even Simon Magus, according to the apocryphal Petrine Acts, and place their death in the end of the first and beginning of the second centuries. These Acts were written in Greek and Latin; according to Achelis the Greek was the original text, and written in Rome in the sixth century; Schaefer on the other hand holds the Latin to have been the older version, and seeks to prove that it emanated from the first half of the fifth century; so remote a date is improbable, and the sixth century is to be preferred as the source of he Acts. According to these legends Nereus and Achilleus were eunuchs and chamberlains of Flavia Domitilla, a niece of the Emperor Domitian; with the Christian virgin they had been banished to the island of Pontia, and later on beheaded in Terracina. The graves of these two martyrs were on an estate of the Lady Domitilla near the Via Ardeatina, close to that of Saint Petronilla.

The author of this legend places the two saints quite differently from Pope Damasus, in his poem: as Nereus and Achilleus were buried in a very ancient part of the catacomb of Domitilla, built as far back as the beginning of the second century, we may conclude that they are among the most ancient martyrs of the Roman Church, and stand in very near relation to the Flavian family, of which Domitilla, the foundress of the catacomb, was a member. In the Epistle to the Romans, Saint Paul mentions a Nereus with his sister, to whom he sends greetings (Romans 16:15), perhaps even the martyr was a descendant of this disciple of the Apostle of the Gentiles. Owing to the purely legendary character of these Acts, we cannot use them as an argument to aid in the controversy as to whether there were two Christians of the name of Domitilla in the family of the Christian Flavian, or only one, the wife of the Consul Flavius Clemens. As to other martyrs of he name Nereus, who are especially noted in the old martyrologies as martyrs of the faith in Africa, or as being natives of that country (e.g., in the Martyrologium Hieronymianum, 11 May, 15 or 16 October, 16 November) though there is one of the name in the present Roman Martyrology under date of 16 October, nothing more is known.