We use an array of proteomic, biochemical and cell biology techniques to study neurodegenerative diseases, particularly amyotrophic lateral sclerosis (ALS, Lou Gehrig’s disease). We are interested in understanding protein degradation and aggregation, oxidative stress, mitochondrial dysfunction and axonal transport in ALS and other neurodegenerative diseases.

Developing innovative proteomic methodologies to enable quantitative analysis of proteins and protein modifications is another interest of the laboratory. Moreover, we have been collaborating to apply proteomic approaches to multiple biomedical fields, including prostate cancer, diabetes and environmental toxicology.

Yang, L.; Gal, J.; Chen, J.; Zhu, H."Self-assembled FUS binds active chromatin and regulates gene transcription."Proceedings of the National Academy of Sciences of the United States of America111,50(2014):17809-14.[PubMed Link] | [ Full text ]