Last Man Standing is a show about a married man with three daughters. Mike Baxter (Tim Allen) is a man's man in a woman's world when he realizes that things have changed in terms of style, preference, and other things. He juggles life between being a husband and parent while working as a marketing director for an outdoor sporting goods store. Mike is the man at work, but in a home full of women, his wife Vanessa (Nancy Travis)and three daughters Mandy (Molly Ephraim), Kristin (Alexandra Krosney) and Eve (Kaitlyn Dever) are there to make sure that he is the odd man out.

When Vanessa returns to work after being at home for most of her life and is promoted, she is packed on with work. Mike has to balance even more things that he is not used to doing and has to do more hands-on parenting then he has done in all his marriage.