Socrates Said," Let foods be your medicine and let medicine be your foods". Let us all practice the values of the past wisdom to build a letter living and living health while we enjoy the delicious drinks

Socrates Said," Let foods be your medicine and let medicine be your foods". Let us all practice the values of the past wisdom to build a letter living and living health while we enjoy the delicious drinks

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Tuesday, April 12, 2016

All About #CurableVitamins: The effects of Vitamin A On Cervical Cancer

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.Vitamins are organic compounds and vital nutrients needed by your body to grow and develop in a profound way.

Vitamin A
Vitamin A, a bi-polar molecule formed by bonds between carbon and hydrogen, is a fat soluble vitamin which can not be stored in the liver but it can be converted from beta-carotene, a powerful antioxidant. The vitamin is best known fir its strong effects in improving vision and enhancing bone growth.

The effects of Vitamin A on Cervical Cancer

Vitamin A is a general term of Vitamin A Retinol, retinal, beta-carotene, alpha-carotene, gamma-carotene, and beta-cryptoxanthin best known for its functions for vision health and antioxidant scavenger and essential for growth and differentiation of a number of cells and tissues.

Cervix is the lower part of uterus that opens at the top of the vagina. Cervix acts an transition area for vaginal lining (squamous epithelium) change to uterus type (columnar epithelium) through the transitional area (squamous columnar epithelium) to host the development of the fetus. Cervical cancer is malignantneoplasm of the cervix uteri or cervical area caused by abnormal cells growth with alternation of cells DNA.

1. The serum of vitamin A
In a total of 144 cervical cancer cases and 288 age-matched, hospital-based controls using unconditional logistic regression models showed a statistically lower mean dietary intakes of vitamin A compared to control(2). Other study found that serum and urine collected are lower from12 women diagnosed with cervicalintraepithelial neoplasia(3)(4)(4a). But the study of Nizam Institute of Medical Sciences, showed no correction of levels of vitamin A intake between cervical cancer patients and normal controls, in a total of total of 60 consecutive patients and 60 controls were enrolled from a referral hospital during the year 2004(6)(7).

2. Retinols
A combination of retinoids with histone deacetylase (HDAC) inhibitors effectively inhibited the growth of cervical cancer cells due to the restore RARβ2 expression, associated with a significant upregulation of p21(CIP1) and p53 as well as a pronounced decrease in p-Stat3(10). In cervical cancer cells line HeLa and CaSki, All-trans retinoic acid (ATRA) derived from retinols, inhibited the proliferation ofcervical cancer cells line HeLa but showed no effect on proliferation CaSki cells(11).
Other derivatives of retinols, all-trans and 9-cis retinoic acid induced profilerative activity of CaSki cells through cell cycle arrest via exhibited the increase in the level of immunophenotypic expression of wild type p53 and inhibited E6/E7 transcription(12). The study of composition of tea polyphenol, (-)-epigallocatechin gallate (EGCG) and retinoic acid (RA), showed to prevent cervicaladenocarcinoma, though induced apoptosis and inhibited telomerase activity(13).

3. Carotenoids
According to the University of Arizona, in the analysis of cervical tissue (cancerous, precancerous, and noncancerous) samples obtained from 87 patients (age, 21-86 years), showed that maintaining an adequate serum concentration of beta-carotene may be necessary for the prevention of cervical cancer and precancer(14). Crocetin is a natural carotenoid dicarboxylic acid, inhibited the cell proliferation of Hela cells through cell cycle arrest via p53-dependent and -independent mechanisms(15). The Albert Einstein College of Medicine and Montefiore Medical Center study, showed a lower correction of mean plasma levels of carotenoids (beta-carotene, lycopene, and canthaxanthin), as well as alpha-tocopherol, in women with cervical intraepithelial neoplasia (CIN)and cervical cancer and suggested that antioxidant deficiency may be associated to the pathogenesis of CIN and carcinoma of the cervix(16). Dr. Harris RW, and the researcher team in the study of Cancer of the cervix uteri and vitamin A indicated that the strong correction of significantly reduced serum beta caroteneconcentrations in women with pre-invasive disease compared to the controls(17).

Taking altogether, Vitamin A may be associated to reduced risk and treatment of cervical cancer, but further studies are necessary to validate its effectiveness. maintaining the adequate levels of vitamin A may be a choice to prevent the onset of the disease. Recommended intakes of vitamin A, according to the Institute of Medicine of the National Academies (formerly National Academy of Sciences) is 600 µg daily as extremely high doses (>9000 mg) can be toxicity as causes of dry, scaly skin, fatigue, nausea,