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Description

LECTURE Feb. 152011 Cell signalling pathways in quite a bit of detail for today Each pathways unique protein involved, signals involved Different signals different responses to each G-proteinlinked receptor GTPase complex receives signal Alpha swaps GDP to GTP Dissociate No signal alpha bound to GDP off Receptor activated induces conformational change in alpha subunit, which causes GDP to dissociate, and GTP binds in its place GTP binding causes further conformational change o Activated alpha subunit dissociates from beta and gamma Both can now regulate activity of target proteins Target proteins convey signal to other proteins Prolonged stimulation receptor becomes inactive, even if ligand is bound Arrestin bound to receptor on cytosolic side Receptor either endocytosed for degradation or it can be recycled for further use to its pathway OUTPUT o cAMP activates PKA indirectly, since PKA exist bound to inhibitory molecules, and cAMP causes inhibitory molecules to fall off phos