Background-Several genera of Labiatae have anti-nociceptive properties with an efficacy similar to classical analgesic drugs.Objective-In this study, the anti-nociceptive activity of Saliva nemorosa extract was evaluated.Methods-Anti-nociceptive properties of the aerial parts of S. nemorosa were studied using hot plate and writhing tests on the aqueous decoction and ethanolic maceration extracts of the aerial parts of this plant.Results-In contrast to the ethanolic extract, intraperitoneal injection of aqueous extract showed anti-nociceptive activity in the hot-plate test which was inhibited by naloxone. In the writhing test, however, considerable anti-nociceptive activity was observed in case of both aqueous as well as ethanolic extracts. Here again, naloxone had an inhibitory effect on the anti-nociceptive properties of only the aqueous extract. Conclusion-This study shows that S. nemorosa had both central and peripheral anti-nociceptive activities that may be mediated by opioid receptors.