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The Waltham-based Center for Digital Imaging Arts program will lose its affiliation with Boston University in May, leading to an uncertain future for the program, officials said.

For the past 10 years, BU has overseen the Moody Street-based CDIA certificate program, said BU spokesman Colin Riley. However, BU officials decided in recent months to end their 10-year relationship this spring with the CDIA, which was started in 2004 in conjunction with the university, Riley said.

“It was a business decision,” Riley said of the termination, declining to comment further.

However, CDIA officials said they are actively seeking other colleges to partner with, noting that they plan on staying in Waltham.

“We’re talking with other institutions right now,” said Bob Frazier, CDIA executive director. “The plan is for the center to keep going, so we’re looking at all the options right now.”

Frazier said he is disappointed in BU’s decision, noting that the college’s reputation played a part in the satellite program’s success.

“We all know the name BU,” he said. “It’s a great university.”

Frazier declined to say if the CDIA was financially stable without a parent affiliate, though he did note that the program is “not backed by the university monetarily.”

Charnan Bray of the Downtown Waltham Partnership said that if the CDIA ends up moving out of Waltham, she hopes the 274 Moody St. space would be re-occupied by a similar tenant.

"I want to make sure there's not a vacancy on Moody Street and that the property is useful to the downtown," she said over the phone last week.

The CDIA also has locations in Washington, DC and Atlanta, according to its website. The program specializes in teaching digital filmmaking, photography, 3D animation, graphic and web design, audio production, and web development.