Research Scientist, Chemistry - Center For Protein Degradation

Located in Boston and the surrounding communities, Dana-Farber Cancer Institute brings together world renowned clinicians, innovative researchers and dedicated professionals, allies in the common mission of conquering cancer, HIV/AIDS and related diseases. Combining extremely talented people with the best technologies in a genuinely positive environment, we provide compassionate and comprehensive care to patients of all ages; we conduct research that advances treatment; we educate tomorrow's physician/researchers; we reach out to underserved members of our community; and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.

Responsibilities

Dana-Farber Cancer Institute (DFCI) and Deerfield Management have entered a multi-year collaboration to create the Center for Protein Degradation (CPD) at DFCI led by Drs. Fischer and Gray. The goals of the Center for Protein Degradation are to create a next-generation protein degrader platform and interrogate and advance a large portfolio of protein degrader targets. This is an exceptional opportunity to join a newly founded research center that is pushing the boundaries of targeted protein degradation research and accelerating the translation of basic science into clinical solutions.

The Center for Protein Degradation (CPD) is seeking an experienced medicinal chemist to join its team. This individual will be centrally involved in assisting various research projects primarily involving protein biochemistry. In addition to bench-based research, responsibilities will include laboratory management and organization. Training is available in all aspects of experimental research.

Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other groups as protected by law.

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VIEW JOBS3/19/2019 12:00:00 AM2019-06-17T00:00Overview
Located in Boston and the surrounding communities, Dana-Farber Cancer Institute brings together world-renowned clinicians, innovative researchers and dedicated professionals, allies in the common mission of conquering cancer, HIV/AIDS and related diseases. Combining extremely talented people with the best technologies in a genuinely positive environment, we provide compassionate and comprehensive care to patients of all ages; we conduct research that advances treatment; we educate tomorrow's physician/researchers; we reach out to underserved members of our community; and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.
Dana-Farber Cancer Institute (DFCI) and Deerfield Management have entered a multi-year collaboration to create the Center for Protein Degradation (CPD) at DFCI led by Drs. Eric Fischer and Nathanael Gray. The goals of the Center for Protein Degradation are to create a next-generation protein degrader platform and interrogate and advance a large portfolio of protein degrader targets. This is an exceptional opportunity to join a newly founded research center that is pushing the boundaries of targeted protein degradation research and accelerating the translation of basic science into clinical solutions. Join our highly interactive team of scientists and technicians to work on testing and creating new avenues of therapeutic intervention.
Responsibilities
* Independently plan, manage, and perform experiments and biology projects. Develop project proposals, timelines and resource needs. Monitor milestones and ensure deliverables are completed on time.
* Develop, implement, and deliver on mechanistic studies for glue and degrader molecules
* Explore novel indications and new drug combinations both in cellular and ex vivo settings
* Identify biomarkers correlating with drug sensitivity and resistance to guide preclinical and clinical development
* Assist in the design and execution of pharmacodynamics assays to monitor protein degradation in live animals
* Collaborate with scientific groups within the Center (e.g., chemistry and animal models teams) to guide compound optimization and inform choice of appropriate in vivo pharmacodynamics and efficacy models, respectively
* Collect and analyze experimental data and identify next steps based on outcomes
* Train research technicians and other scientific staff in methods/techniques and supervise on specific projects
* Interact and liaise with internal experts, external experts, academic groups, and CROs to establish collaborations and projects
* Prepare presentations and present project status and outcomes at internal and external meetings
* Prepare papers and publications, if necessary
* Maintain clear and accurate records of experimental work (e.g., experimental methods, results/findings)
Qualifications
Minimum Requirements
* PhD degree in molecular/cellular biology, biochemistry, or a related discipline with at least 2 years of relevant postdoctoral experience, preferably in an industrial setting
* Demonstrated leadership in research projects related to drug development or translational applications
* Familiarity with the techniques common to translational research including, but not limited to flow cytometry, proliferation/ viability assays, genomics, and proteomics
* Excellent communication and presentation skills.
* Scientific drive, demonstrated by a proven track record of publications in peer reviewed journals
* Demonstrated ability to work in a fast-paced and dynamic environment.
* Ability to work independently as well as in a collaborative and team environment
* Proficiency in all common Microsoft Office and GraphPad Prism software
* Excellent organizational and prioritization skills. Strong attention to detail
Preferred Qualifications
* Experience in oncology and mammalian gene expression is preferred
* Experience in running multi-faceted projects is preferred
* Experience managing more junior staff is desirable
Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other groups as protected by law.
Dana-Farber Cancer InstituteBostonMA

VIEW JOBS3/13/2019 12:00:00 AM2019-06-11T00:00Overview
Located in Boston and the surrounding communities, Dana-Farber Cancer Institute brings together world renowned clinicians, innovative researchers and dedicated professionals, allies in the common mission of conquering cancer, HIV/AIDS and related diseases. Combining extremely talented people with the best technologies in a genuinely positive environment, we provide compassionate and comprehensive care to patients of all ages; we conduct research that advances treatment; we educate tomorrow's physician/researchers; we reach out to underserved members of our community; and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.
Dana-Farber Cancer Institute (DFCI) and Deerfield Management have entered a multi-year collaboration to create the Center for Protein Degradation (CPD) at DFCI. The Center for Protein Degradation (CPD) is seeking an experienced and highly motivated Scientific Director to oversee and coordinate the Center's scientific activities and operations. The Scientific Director will report directly to the Center Directors and will work closely with them to fulfill the Center's scientific mission and goals. This is an exciting opportunity to help implement and operate the Center for Protein Degradation as a global center of excellence for targeted protein degradation discovery.
Responsibilities
* Oversee, coordinate, and manage daily Center operations, including wet lab and informatics activities. Act as a liaison, working with faculty and staff within and outside the center to coordinate CPD activities within DFCI and with external entities (e.g., CROs, etc.)
* Provide oversight, guidance, mentorship, and development of CPD scientific staff (PhD and non-PhDs)
* Assist with the prioritization, selection, and design of Center research projects and activities
* Ensure the successful and timely execution of projects, working with scientific group leaders, Directors, and Executive Director to anticipate, identify, and resolve issues on an ongoing basis.
* Serve as the chief scientific interface between CPD and Deerfield
* Work with CPD leadership to identify new technologies, methods, and/or innovations that may accelerate or improve protein degradation research and direct projects in high-priority areas.
* Partner with research scientists and other scientific staff to conduct new method/ technology/tool development, validation and/or proof-of-concept studies.
* Evaluate and oversee the development of the Center's research infrastructure and systems
* Work with the Center Directors and Executive Director to develop and implement policies, procedures, and tools that ensure efficient Center operations that meet all regulatory guidelines.
* Present reports on the Center's performance to CPD staff, Directors, and Deerfield and DFCI leadership
* Author or co-author scientific manuscripts. Assist with proposal writing and progress reports.
* Present research results on behalf of the CPD at scientific meetings and related venues.
Qualifications
The CPD Scientific Director must fulfill the following requirements:
* PhD or MD level education; at least 10 years of postdoctoral experience. Prior leadership of large research projects is preferred
* Experience/concentration in biomedical science (including chemistry), with increasing responsibility in biomedical research and/or drug discovery and development
* Background/experience in oncology drug development is preferred.
* Knowledge of research methodologies and emerging technologies such as: small molecular hits to leads trajectory, including HTS screening, medicinal chemistry, structural biology, proteomics, target ID, PK/PD, and ADME.
* Highly organized and self-directed - works well in a constantly changing environment
* Ability to work closely and effectively with a diverse group of individuals—from trainees to senior leaders—in both academics and industry
* Entrepreneurial attitude and skills, including a willingness to take risks
* Capable of highly-independent work as well as being a team player and role model
* Strong organizational, project management and supervisory skills, with the demonstrated ability to develop and manage complex projects in a matrix environment
* Superior communication skills(written and verbal)
* Strong attention to detail
This is a 40 hour per week, full time position.
Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other groups as protected by law.
Dana-Farber Cancer InstituteBostonMA

VIEW JOBS3/20/2019 12:00:00 AM2019-06-18T00:00EXPECT MORE FROM YOUR CAREER
EXPECT PPD
PPD is a leading global contract research organization. At PPD we are passionate, deliberate, and driven by our purpose - to improve health.
PPD Laboratories offers the most comprehensive set of laboratory services available in the industry and continues to deliver innovative solutions to our clients through our collaborative approach, including PPD Laboratories FSP. PPD Laboratories FSP is a unique partnership that allows our clients to leverage the experience of our PPD staff, while allowing you, the employee, to gain direct experience working onsite at a pharmaceutical/ biopharmaceutical company, all while maintaining full-time benefits/advantages of being a part of PPD.
As an Associate Research Scientist, you are a highly motivated, scientifically driven and enthusiastic individual who will design and develop chemistry on a synthetic project while conducting laboratory experiments to enable the delivery of compounds to support toxicology studies, human studies, and technical transfer information internally and to contract research organizations externally. You may develop new chemistry, improve existing chemistry and demonstrate such chemistries by delivering compounds at expected purity and batch size for the appropriate phase of development.
Additional responsibilities for the role on site at a major pharma/biotech company:
* Design and perform synthetic organic experiments efficiently, independently and in a fit-for-purpose fashion for the stage of development (pre-clinical through process validation).
* Perform reaction process monitoring using a variety of analytical methods and work with analysts to develop sufficient methods.
* Generate effective hypotheses to pursue synthesis or manufacturing goals and set new experimental direction.
* Understands and is able to develop synthetic plans for synthesis development of molecules.
* Identifies impact of results on the overall process development timeline.
* Provides technical recommendations regarding process chemistry by assisting other chemists in the department and/or articulating issues to upper management.
* Makes conceptual contributions to development activities and scientific strategies.
* Ability and track record of successfully working in cross-functional teams.
* Author reports and regular updates at appropriate project intervals while maintaining excellent and reproducible laboratory records.
Grow your career within the scientific ladder, pursue project management, or develop into a leader. These are just a few career pathways available once you chose to Be with PPD.
Join PPD in our relentless pursuit of excellence - apply now!
Education and Experience:
* Bachelor's degree in Chemistry, Organic Chemistry, MedicinalChemistry or equivalent and relevant formal academic / vocationalqualification
* Previous experience that provides the knowledge, skills, andabilities to perform the job (comparable 6+ year) and abilities toexecute on multi-step organic chemistry experiments or equivalentcombination of education, training, & experience.
OR
* Masters degree andprevious experience that provides the knowledge, skills, and abilitiesto perform the job (comparable 4+ year) OR
PhD and previous experience that provides the knowledge, skills, and abilities to perform the job (comparable 2+ year)
* Previous relevant process chemistry experience strong preferred
Knowledge, Skills and Abilities:
* Knowledge of general chemistry and separation science - HPLC and NMR
* Familiar with SOPs and GMPs and ensure compliance with all applicable regulations and SOPs.
* Ability to independently root cause analysis for method investigations
* Proven ability in drafting, reviewing and submitting requireddocumentation pertaining to the development and preparation of drugsubstances under cGMP environment is desirable.
* Proficiency with lab automation equipment a plus
* Proven problem solving and troubleshooting abilities
* Ability to multitask to effectively manage multiple activities.
* Proven ability in technical writing skills
* Time management and project management skills
* Good written and oral communication skills
* Ability to work in a collaborative work environment with a team
Working Conditions
* Work is performed in a laboratory environment.
* Rare exposure to skin and lung irritants, radiation, toxic materials and hazardous waste.
* Personal protective equipment required such as protective eyewear, garments and gloves.
Physical Requirements
* Occasional crouching, stooping, with frequent bending and twisting of upper body and neck.
* Light to moderate lifting and carrying (or otherwise moves) objectsincluding luggage and laptop computer with a maximum lift of 15-20 lbs.
* Frequently interacts with others to obtain or relate information to diverse groups.
PPD is an affirmativeaction employer that values diversity as a strength and fosters anenvironment of mutual respect. PPD provides equal employmentopportunities without regard to age, race, color, pregnancy, nationalorigin, religion, sex, gender identity, sexual orientation, disability,veteran status or other status within any other protected group.
Additional Information
* Requisition ID: 149815
PPDBostonMA

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