Methods. In total 238 patients with early RA were followed longitudinally and 108 were available for the 15-year followup examination. Comprehensive baseline clinical and radiographic data were collected in 1992. Arterial stiffness, measured as AIx and PWV (Sphygmocor apparatus), was recorded at the 15-year followup. Adjusted logistic univariate and multivariate analyses were performed with levels of AIx and PWV as the dependent variables, and variables reflecting baseline RA disease activity as possible predictors. The validity of the final models was examined in linear regression analyses.

Conclusion. Inflammation early in the RA disease course was associated with increased AIx and PWV after 15 years. These findings support the importance of early control of the inflammatory process in patients with RA.

Footnotes

Supported by grants from the Eastern Norway Regional Health Authority. The Euridiss data collection was supported by The Research Council of Norway, The Norwegian Rheumatism Association, The Norwegian Women’s Public Health Association, the Grethe Harbitz Legacy, and the Marie and Else Mustad’s Legacy.