This study investigates the safety of two up-dosing regimen. The safety of PURETHAL Grasses will be evaluated in a rush regimen (maximum dose reached in 3 injections during 2 weeks) compared to the conventional regimen (maximum dose reached in 6 injections during 5 weeks).

The primary parameter will be the proportion of patients who experience systemic reactions > grade I within 24 hours after injection or who need more than 2 additional injections during the up-dosing phase until the maintenance dose has been reached.

It is expected that up-dosing PURETHAL Grasses according to the rush regimen is as safe as using the conventional regimen.

Patients being in relationship or dependence with the sponsor or investigator.

Allergy to any of the excipients.

Severe illness or any other condition, which makes the patient, in the opinion of the investigator, unsuitable for the study.

Contacts and Locations

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Please refer to this study by its ClinicalTrials.gov identifier: NCT01059266