According to avoid the compromising the immune system after exhaustive exercise and the role of micronutrients in this background, the aim of this study was to investigate the effect of vitamin C supplementation on the salivary immunoglobulin A, cortisol and total protein concentration on active girls college following exhaustive physical activity program. In this semi-experimental study, 17 active girl (age 22.11 ± 2.36), weight 55.70 ± 6.81 kg, and body mass index 20.88 ± 2.25 kg.m2 voluntarily participated and randomly assigned into three groups: exercise - vitamin C supplementation (n=6), exercise (n=5) and control group (n = 6). exercise - vitamin C supplementation group performed an exhaustive physical activity program (7 days in AM and PM) with receive daily 500 mg vitamin C tablets at lunch time, exercise groups performed same protocol without supplementation receive, and the control group performed neither the physical activity nor received the supplement. Saliva samples were collected one day before starting the physical activity program and also 24 and 72 hours after the last session, in 9:30 morning. The One-Way ANOVA test was used to comparison of means among groups. The results showed there was no significant difference in salivary IgA concentrations between groups in 24 hours (P=0.9 and F=0.4) and 72 hours after the last session exercise (P=0.1 and F=0.8), and also in cortisol concentrations, in 24 hours (P=0.7 and F=0.2)

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