Pain Control After Cardiac Surgery Using Intravenous Acetaminophen

This study has been completed.

Sponsor:

The Cleveland Clinic

ClinicalTrials.gov Identifier:

NCT01822821

First Posted: April 2, 2013

Last Update Posted: May 15, 2017

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government.
Read our disclaimer for details.

Cumulative Opioid Consumption [ Time Frame: End of surgery through 24 hours after surgery ]

Evaluate the noninferiority and efficacy of IV acetaminophen; compared to a placebo, in reducing opioid consumption a after cardiac surgery. Total opioid consumption is defined as the total amount amount of opioids administered to patients converted to mg morphine equivalents.

Pain Intensity [ Time Frame: End of surgery through 24 hours after surgery ]

Evaluate the noninferiority and efficacy of IV acetaminophen; compared to a placebo, in reducing pain intensity scores after cardiac surgery. Pain scores were measured on the Numeric Rating scale, ranging from 0 to 10 (where 0 indicates no pain and 10 indicates the worst pain imaginable).

Postoperative sedation was assessed using the Richmond Agitation Sedation Scale (RASS). It ranges from -5 to +4, where -5 indicates no response to voice or physical stimulation and +4 indicates overtly combative or violent and immediate danger to staff. Lower the value, better the sedation.

Duration of Mechanical Ventilation (Minutes) [ Time Frame: End of surgery until the initial end of ventilation or date of death from any cause, whichever came first, assessed up to 1 week. ]