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The tracheobronchial route may be used alternatively to the IV route at a dose of 3 mg (3 ml) diluted in 10 ml of 0.9% sodium chloride solution in single dose.

Infants and Children

Route IV: In bolus of 0.01 mg / kg, then if necessary, an additional dose of 0.1 mg / kg every 3-5 minutes until recovery of haemodynamic state. >

The tracheobronchial route may be used alternatively to the IV route at a dose of 0.1 to 0.3 mg / kg as a single dose. >
Treatment of anaphylactic shock, established

Adults

Route I.M .: 0.5-1 mg (0.5-1, ml), repeated every 5 minutes if necessary.
Route IV: 1 ml dilution (1 mg) in 10 ml of 0.9% sodium chloride solution followed by intravenous bolus administration of 1 ml of the diluted solution, ie 0.1 mg of adrenaline . The boluses will be repeated until recovery, from the hemodynamic state. Close monitoring will be introduced.

0.3 ml of the solution (undiluted) is 0.3 mg of adrenaline, and improvement usually appears within 3 to 5 minutes after the injection, subcutaneously. A second injection of 0.3 ml of the solution (undiluted) can be made 10 to 15 minutes, later if necessary.
Infants and Children

The doses will be in the child, either by I.M. or subcutaneously (0.01 mg / kg)
· Less than 2 years (up to 12 kg): 0.05 to 0.1 ml of the solution (undiluted) of 0.05 to 0.1 mg of adrenaline

· From 2 to 6 years (12 to 18 kg): 0.15 ml of the solution (undiluted) ie 0.15 mg of adrenaline >
· 6 to 12 years (18 to 33 kg): 0.2 ml of the solution (undiluted) ie 0.2 mg of adrenaline.
Treatment of distress, cardiovascular with states of shock

Administration at the syringe of a continuous dose of between 0.01 microgram / kg / minute and 0.5 microgram / kg / minute, the mean dosage being titrated according to the desired therapeutic effect.

Adrenaline is a direct-acting sympathomimetic amine with effects on both alpha and beta-adrenergic receptors (beta 1 and beta 2), but with a more pronounced beta effect at low therapeutic doses while That the alpha effect is more marked at high therapeutic doses.

The use of adrenaline is based mainly on the following properties

· Vasoconstriction device

· Positive and positive inotropic bathmotrope cardiac action

· Relaxing action of the bronchial musculature and inhibition of the release of mediators of inflammation and allergy

Not applicable.

· Rhythm disorders (especially ventricular)

· Severe obstructive cardiomyopathy

· Coronary insufficiency

This medication being indicated in an emergency situation, these contraindications are:

Warnings

Adrenaline, Aguettant 1 mg / ml SULFITE is indicated only as an emergency treatment. Medical follow-up is essential after administration.

Any intravenous administration of adrenaline may lead to disorders: ventricular rhythm with risk of ventricular fibrillation, sometimes lethal

Adrenaline should be administered by I.M or SC in the event of anaphylactic reaction prodromes such as

· Generalized pruritus of the mucous membranes or erythema

· Labial or oropharyngeal edema

· Chest tightness

· Profuse sweating

· Hypotension.

In all types of shock, administer adrenaline only after blood volume re-establishment.
This medicinal product contains 3.15 mg sodium per ml solution for injection: take this into account in people on a strictly sodium-based diet

The attention of sportsmen and sportswomen will be drawn to the fact that this specialty contains an active ingredient which can induce a positive reaction of the tests performed during the antidoping tests. Code>
Concomitant use of this drug intravenously or intramuscularly is not recommended in combination with halogenated volatile anesthetics, imipraminic antidepressants or mixed adrenergic-serotonergic drugs (see Interactions with other medicinal products and others; Forms of interactions with other medicines and other forms of interaction)

Severe ventricular rhythm disorders, increased cardiac excitability. Limit the intake, for example: less than 0.1 mg of adrenaline in 10 minutes or 0.3 mg in 1 hour in adults

After dilution in 0.09% sodium chloride solution, the product should be used immediately.
In the absence of compatibility studies, this drug should not be mixed with other medicines.
Never dilute in alkaline solutions

The effects of adrenaline may be antagonized, depending on the condition of the patient, by the administration of fast-acting vasodilators of adrenergic alpha-adrenergic drugs, noradrenaline, or even beta-adrenergic blockers. However, since the half-life of adrenaline is very short, it is not always necessary to have recourse to these drugs.

Pregnancy

Studies in animals have demonstrated a teratogenic effect.

Clinical use of adrenaline in a limited number of pregnancies has not revealed any particular malformative or fetotoxic effects to date, but additional studies are needed to assess the consequences; Of an exposure during pregnancy.

Given the indications in the situation, emergency, adrenaline can be used, if necessary, during pregnancy.

The passage of adrenaline into breast milk is not known. In view of the potential adverse effects to the newborn breast-fed, breast-feeding is not recommended during treatment with adrenaline. >
The undesirable effects depend on the sensitivity of the patient and the administered dose.