Bullous and blistering diseases of the skin comprise a heterogeneous group of symptoms, which are essentially characterized by a common injury: blisters. Pemphigus and pemphigoid disorders are classified as blistering autoimmune diseases. The genital prolapse is the falling down or displacement of the pelvic organs through the vagina or towards the vulva, and which results from the loss of support structure and innervation and from a weak muscular tissue in both the urinary and intestinal system. What we are trying to show here is our experience and expertise in the care, management and topical treatment of bullous pemphigoid wounds in severe pelvic viscera prolapse, which used to make surgery difficult.