Successful completion of the cell division cycle is critical for cellular duplication and survival. There are many regulators and checkpoints to ensure the proper cell cycle progression. Disruption of the machinery involved in completion, error...

Chromosomal instability (CIN) is defined as a high rate of whole chromosome loss or gain and is a hallmark of many aneuploid solid tumors. CIN positively correlates with poor patient prognosis and chemotherapeutic resistance. The persistence of...

Proper chromosome alignment and segregation depends on the formation and maintenance of a bipolar mitotic spindle with focused poles. It has been shown that microtubules are focused at spindle poles through the combined actions of centrosomes and a...

A pre-requisite for proper health of the cell and the organism is accurate chromosome segregation during cell division. Defects in chromosome segregation lead to aneuploidy, a hallmark of an unstable genome and a frequent attribute of cancer and...

DNA damage induces cell cycle arrest through both Chk1 and the p53 tumor suppressor protein, the latter arresting cells through induction of p21waf1 protein. Arrest permits cells to repair the damage and recover. The frequent loss of p53 in tumor...

Formins are actin nucleators that modulate the nucleation and elongation of actin filaments. Formin homology 1 (FH1) and formin homology 2 (FH2) domains play a key role in formin-mediated actin dynamics. INF2 is a unique formin which can both...

Testicular germ cell tumors (TGCTs) are highly curable with cisplatin-based therapy. The p53 tumor suppressor is induced in response to a variety of cellular stresses. Our previous work has implicated an important role for p53 in TGCT...

NIMA-related kinases (Neks) control several aspects of cell division downstream of master mitotic regulators such as Cdk1 and Plk1. Though depletion of Nek6, Nek7, or Nek9 results in cytokinesis failure, to date no molecular mechanism has been...

Successful traversal of the cell division cycle is paramount for maintaining a cell's genomic integrity and fitness. To ensure the faithful replication and segregation of the genome, cellular components, and cytoplasm, eukaryotes have evolved a...

Most solid tumors are aneuploid, and many tumor cells persistently mis-segregate whole chromosomes at an elevated rate in a process called chromosomal instability (CIN). CIN occurs due to loss of chromosome segregation fidelity during mitosis,...

Human cancer is developed as the consequence of the activation of oncogenes and inactivation of tumor suppression genes. Modern sciences has identified and characterized the functions of such genes to understand the mechanism of cancer development...

DNA can be damaged by many endogenous and exogenous factors. In response to DNA damage, cells activate cell cycle checkpoints to stop the cell cycle and allow time for repair of the damage. Defects in these pathways allow replication to continue...

Solid tumors are frequently aneuploid and many display high rates of ongoing chromosome mis-segregation in a phenomenon called chromosomal instability (CIN). The most common cause of CIN is the persistence of aberrant kinetochore-microtubule (k-MT)...

Actin filaments are integral to a large number of cellular structures. Due to the widespread use of actin, cells must rigorously control when and where new filaments assemble. Formin proteins are expressed in all eukaryotes and provide the...

Faithful chromosome segregation is vital for cell and organism viability, but is lost in many cancer cells with aneuploid karyotypes that display chromosomal instability (CIN). In normal cells, correct chromosome segragation is ensured through two...