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he STA Fibrinogen Kit is intended for the quantitative determination of fibrinogen in plasma by the Clauss clotting method. In the presence of an excess of thrombin, the clotting time of diluted plasma is inversely proportional to the level of plasma fibrinogen. The clot is detected by the STA-R Evolution. The STA-R Evolution is a fully automated coagulation instrument that uses an electromagnetic viscosity detection system. The oscillation of a steel ball within the cuvette with the thrombin and diluted plasma is monitored by the STA-R Evolution. At the constant viscosity; constant pendular swings of the ball are obtained within an electromagneticfield. As the viscosity increases as a result of the coagulation, the oscillation amplitude of the ball swing decreases. An algorithm uses these variations in oscillation amplitude to determine the clotting time. The time is read from a stored curve on the STA-R Evolution. An increase of the fibrinogen level is observed in cases of diabetes, inflammatory syndromes, and obesity. A decrease of the fibrinogen level is observed in DIC, fibrinolysis and hereditary diseases.(Package insert: STA Fibrinogen, Diagnostica Stago, Inc.)