The endurance in exercising supports optimal physical training to improve physical health and fitness. Two major factors in decreasing sport endurance are dehydration and loss of carbohydrates in muscle during exercise. Coconut water is a potential sports drink because it has low acidity, sugars, minerals content and is isotonic. This research aims to know the effects of coconut water consumption towards endurance and fitness measured from VO2max and mileage during running exercise. The study was conducted in FPOK UPI Bandung during July 2015 to February 2016. Research material used was coconut water, mineral water, 5% sugar water, and isotonic sports drink. The subjects were 120 men, aged 18–23 years old, divided into 4 groups for each of the test material. After warming up, the subjects ran quickly for 30 minutes. Test materials were given before and every 10 minutes during the run. Distance traveled was recorded in units of meters. Data was analyzed using one-way ANOVA test followed by the least significant difference (LSD) test with α<0.05. The longest distance and highest VO2max were obtained by the group treated with coconut water, followed by 5% sugar water, isotonic sports drinks, and mineral waters (p<0.01). In conclusion, coconut water consumption before and during exercise can improve sports endurance on non-athlete adult male.