Sports writer Kevin Iole in the post fight video commentary stated that the controversial ending in Pacquiao-Marquez III presented a better case for a fourth match between the two, and predicted Floyd Mayweather would fight Amir Khan instead on May 5, 2012. Khan then lost a split decision to Lamont Peterson the following month. Mayweather and Miguel Cotto then agreed to fight on May 5.

CompuBox statistics showed that, in terms of overall landed punches, Pacquiao out-landed Marquez in nine rounds. Marquez out-landed Pacquiao in one (Round 8). They landed an equal number in two (Rounds 3 & 9). In terms of power punches landed, according to CompuBox statistics, Pacquiao out-landed Marquez in eight of the rounds.

After the decision was announced, some of the pro-Marquez crowd reacted by throwing food, ice, and beer; a beer can hit a ringside writer, though no injuries were reported.

Ignacio "Nacho" Beristain, Marquez's trainer, indicated that he would pursue legal action against the judges shortly after the fight; however, he has yet to do so.

The bout generated 1.4 million pay per view buys, a figure which equaled the second highest for a non-heavyweight bout in boxing history (tied with the September 18, 1999, bout between Felix Trinidad and Oscar De La Hoya and the May 7, 2010, match between Floyd Mayweather, Jr. and Shane Mosley).

Gordon Marino, The Wall Street Journal: 114-114 Draw (Note: At the end of his live blog of the fight, he indicated his belief that Marquez had won; however, in his round-by-round, he scored Rounds 1-2, 5-7 and 12 for Marquez and Rounds 3-4 and 8-11 for Pacquiao.)