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MAMMOGRAPHIC DENSITY AND DIFFERENT BREAST CANCER
SUBTYPES DEFINED BY PROGNOSTIC BIOMARKERS
by
Jianning Luo
A Thesis Presented to the
FACULTY OF THE GRADUATE SCHOOL
UNIVERSITY OF SOUTHERN CALIFORNIA
In Partial Fulfillment of the
Requirements for the Degree
MASTER OF SCIENCE
(APPLIED BIOSTATICS AND EPIDEMIOLOGY)
May 2008
Copyright 2008 Jianning Luo

Mammographic density is a strong risk factor for breast cancer. However, it has been unclear whether it is a risk factor for all the subtypes of breast cancer defined by prognostic biomarkers.; We examined the association of mammographic density with subtypes of breast cancer (defined using immunohistochemical analysis of breast tumors) among 479 female breast cancer patients and 376 controls aged 35-64 years in Los Angeles County using multivariable unconditional logistic regression models. The subtypes we focused on include basal-like (defined as ER-, PR-, HER2-) and luminal A (defined as ER+ and/or PR+, HER2-).; Mammographic density was positively associated with both basal-like and luminal A breast cancers among postmenopausal women (both ptrend < 0.03). Women having 60 and more percent mammographic density had approximately 2-3 times higher risk for these two subtypes compared to those with less than 10 percent of mammographic density.; Our results suggest that mammographic density is a risk factor for both basal-like and luminal A breast cancer.

MAMMOGRAPHIC DENSITY AND DIFFERENT BREAST CANCER
SUBTYPES DEFINED BY PROGNOSTIC BIOMARKERS
by
Jianning Luo
A Thesis Presented to the
FACULTY OF THE GRADUATE SCHOOL
UNIVERSITY OF SOUTHERN CALIFORNIA
In Partial Fulfillment of the
Requirements for the Degree
MASTER OF SCIENCE
(APPLIED BIOSTATICS AND EPIDEMIOLOGY)
May 2008
Copyright 2008 Jianning Luo