GREMLIN Results:
Residue pairs sorted by strength in covariance:Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

i

j

Raw Score

Scaled Score

45_D

69_Y

0.50003

3.473

36_D

39_K

0.4995

3.470

25_K

70_D

0.47617

3.308

51_S

90_R

0.44694

3.105

86_E

90_R

0.4448

3.090

89_C

118_F

0.43537

3.024

113_Q

117_R

0.40841

2.837

42_D

46_V

0.37196

2.584

81_E

107_G

0.35522

2.467

8_I

20_A

0.33661

2.338

20_A

73_V

0.31846

2.212

116_M

128_K

0.30456

2.116

59_L

72_I

0.29467

2.047

54_D

57_E

0.29389

2.041

21_A

147_Y

0.28778

1.999

51_S

54_D

0.28616

1.988

133_T

158_V

0.2853

1.982

114_E

118_F

0.27417

1.904

61_E

67_A

0.25825

1.794

24_P

71_T

0.25814

1.793

2_K

127_G

0.24666

1.713

136_A

149_R

0.2456

1.706

47_I

57_E

0.24365

1.692

60_D

66_E

0.24297

1.688

28_F

42_D

0.24162

1.678

25_K

69_Y

0.2311

1.605

27_L

69_Y

0.22549

1.566

49_I

57_E

0.22181

1.541

169_V

172_L

0.21474

1.492

8_I

19_L

0.21207

1.473

13_G

18_T

0.21166

1.470

55_F

80_L

0.20934

1.454

27_L

61_E

0.2036

1.414

53_E

90_R

0.20088

1.395

168_V

172_L

0.19807

1.376

39_K

48_P

0.19318

1.342

57_E

61_E

0.18916

1.314

27_L

62_L

0.18795

1.306

21_A

41_L

0.1861

1.293

29_I

58_A

0.1854

1.288

24_P

70_D

0.18467

1.283

33_N

52_W

0.17913

1.244

57_E

60_D

0.17643

1.226

86_E

89_C

0.17623

1.224

72_I

128_K

0.17269

1.200

20_A

28_F

0.17209

1.195

7_L

166_F

0.16618

1.154

60_D

65_D

0.164

1.139

81_E

111_L

0.16315

1.133

151_K

154_L

0.15854

1.101

13_G

17_T

0.15781

1.096

47_I

50_T

0.15749

1.094

3_P

34_G

0.15743

1.094

16_K

75_D

0.15619

1.085

107_G

110_E

0.15565

1.081

4_I

37_S

0.1556

1.081

46_V

49_I

0.15148

1.052

28_F

73_V

0.15102

1.049

53_E

91_Q

0.15065

1.046

157_K

164_G

0.14824

1.030

122_L

175_E

0.14766

1.026

77_I

115_F

0.14754

1.025

69_Y

74_I

0.14563

1.012

61_E

69_Y

0.14458

1.004

44_G

51_S

0.14446

1.003

61_E

66_E

0.14436

1.003

2_K

68_D

0.1429

0.993

13_G

121_K

0.14237

0.989

111_L

114_E

0.14217

0.988

109_G

125_A

0.14193

0.986

25_K

68_D

0.14098

0.979

13_G

153_K

0.14082

0.978

35_S

80_L

0.13551

0.941

133_T

170_G

0.13521

0.939

7_L

169_V

0.13463

0.935

26_P

71_T

0.13334

0.926

83_M

86_E

0.13264

0.921

26_P

30_D

0.13234

0.919

111_L

118_F

0.1318

0.916

6_I

73_V

0.13171

0.915

26_P

45_D

0.13102

0.910

160_N

174_V

0.12962

0.900

4_I

30_D

0.12665

0.880

120_D

128_K

0.12614

0.876

136_A

174_V

0.12524

0.870

56_L

60_D

0.12303

0.855

89_C

135_H

0.12297

0.854

114_E

117_R

0.12279

0.853

3_P

127_G

0.12232

0.850

154_L

170_G

0.12145

0.844

2_K

24_P

0.12095

0.840

10_G

172_L

0.12041

0.836

124_N

135_H

0.1202

0.835

27_L

53_E

0.12017

0.835

70_D

148_T

0.11935

0.829

145_G

153_K

0.11935

0.829

80_L

100_G

0.11889

0.826

65_D

113_Q

0.1188

0.825

3_P

14_S

0.11794

0.819

78_S

134_A

0.11772

0.818

15_G

75_D

0.11749

0.816

14_S

20_A

0.11666

0.810

129_N

169_V

0.11635

0.808

57_E

124_N

0.11616

0.807

53_E

57_E

0.11598

0.806

67_A

149_R

0.11568

0.804

2_K

70_D

0.1153

0.801

110_E

114_E

0.11528

0.801

29_I

74_I

0.11413

0.793

8_I

175_E

0.11392

0.791

43_D

46_V

0.11283

0.784

60_D

67_A

0.11253

0.782

2_K

39_K

0.11167

0.776

61_E

65_D

0.11111

0.772

132_F

152_P

0.11104

0.771

10_G

16_K

0.11043

0.767

113_Q

116_M

0.10965

0.762

18_T

21_A

0.10955

0.761

3_P

168_V

0.10942

0.760

71_T

129_N

0.10885

0.756

50_T

69_Y

0.10884

0.756

30_D

133_T

0.10877

0.756

101_D

105_G

0.10824

0.752

115_F

167_D

0.1082

0.752

2_K

29_I

0.10803

0.750

6_I

168_V

0.10777

0.749

43_D

53_E

0.10747

0.747

35_S

49_I

0.10678

0.742

116_M

132_F

0.10671

0.741

81_E

114_E

0.10626

0.738

4_I

48_P

0.10596

0.736

54_D

66_E

0.10592

0.736

12_P

163_P

0.10559

0.733

40_F

114_E

0.10548

0.733

106_K

115_F

0.1044

0.725

35_S

55_F

0.10419

0.724

123_L

128_K

0.10416

0.724

51_S

58_A

0.10348

0.719

27_L

72_I

0.10333

0.718

8_I

131_I

0.10327

0.717

5_K

59_L

0.10318

0.717

165_W

169_V

0.10285

0.714

69_Y

118_F

0.10281

0.714

77_I

112_Q

0.10251

0.712

72_I

131_I

0.10206

0.709

83_M

90_R

0.10177

0.707

31_T

68_D

0.10144

0.705

61_E

74_I

0.10138

0.704

32_E

76_S

0.10132

0.704

121_K

145_G

0.10117

0.703

74_I

118_F

0.10095

0.701

31_T

74_I

0.10088

0.701

100_G

122_L

0.10058

0.699

30_D

56_L

0.10038

0.697

36_D

61_E

0.1

0.695

146_K

151_K

0.0997

0.693

35_S

46_V

0.09928

0.690

41_L

119_I

0.09926

0.689

25_K

45_D

0.09904

0.688

116_M

120_D

0.09886

0.687

40_F

49_I

0.09884

0.687

32_E

170_G

0.09872

0.686

22_S

38_L

0.09814

0.682

50_T

90_R

0.09814

0.682

29_I

72_I

0.09799

0.681

67_A

71_T

0.09779

0.679

77_I

150_Y

0.09771

0.679

160_N

169_V

0.09746

0.677

31_T

49_I

0.09722

0.675

17_T

37_S

0.09684

0.673

76_S

163_P

0.09611

0.668

36_D

40_F

0.09601

0.667

27_L

67_A

0.09592

0.666

5_K

119_I

0.09589

0.666

86_E

160_N

0.09578

0.665

161_E

164_G

0.09572

0.665

14_S

39_K

0.09565

0.664

65_D

90_R

0.09565

0.664

157_K

167_D

0.09552

0.664

4_I

49_I

0.09521

0.661

14_S

156_K

0.09506

0.660

34_G

87_Y

0.09505

0.660

32_E

78_S

0.09477

0.658

67_A

117_R

0.09475

0.658

86_E

91_Q

0.09436

0.655

18_T

80_L

0.09399

0.653

49_I

54_D

0.09398

0.653

61_E

83_M

0.09388

0.652

34_G

52_W

0.0937

0.651

65_D

68_D

0.09335

0.648

120_D

152_P

0.09313

0.647

59_L

91_Q

0.09311

0.647

3_P

6_I

0.09279

0.645

80_L

111_L

0.09272

0.644

46_V

121_K

0.09266

0.644

24_P

44_G

0.09254

0.643

4_I

50_T

0.09245

0.642

18_T

41_L

0.09241

0.642

27_L

44_G

0.09234

0.641

101_D

153_K

0.09198

0.639

5_K

72_I

0.0919

0.638

29_I

49_I

0.09167

0.637

79_W

171_R

0.09134

0.634

2_K

118_F

0.0912

0.634

105_G

108_Y

0.0911

0.633

133_T

156_K

0.09105

0.632

25_K

56_L

0.0909

0.631

111_L

119_I

0.09079

0.631

31_T

56_L

0.0907

0.630

11_P

136_A

0.09067

0.630

91_Q

100_G

0.09066

0.630

136_A

165_W

0.09044

0.628

67_A

86_E

0.09033

0.627

39_K

130_V

0.09007

0.626

40_F

109_G

0.08998

0.625

162_L

174_V

0.08997

0.625

24_P

53_E

0.08993

0.625

38_L

78_S

0.0899

0.624

27_L

70_D

0.08986

0.624

101_D

155_G

0.0898

0.624

130_V

133_T

0.08979

0.624

46_V

50_T

0.08958

0.622

52_W

108_Y

0.08952

0.622

19_L

135_H

0.08943

0.621

3_P

7_L

0.08937

0.621

Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.

HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits: Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)