cefprozil, Cefzil (cont.)

Omudhome Ogbru, PharmD

Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

Charles Patrick Davis, MD, PhD

Dr. Charles "Pat" Davis, MD, PhD, is a board certified Emergency Medicine doctor who currently practices as a consultant and staff member for hospitals. He has a PhD in Microbiology (UT at Austin), and the MD (Univ. Texas Medical Branch, Galveston). He is a Clinical Professor (retired) in the Division of Emergency Medicine, UT Health Science Center at San Antonio, and has been the Chief of Emergency Medicine at UT Medical Branch and at UTHSCSA with over 250 publications.

Jay W. Marks, MD

Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

STORAGE: Tablets should be kept at room temperature, 15 C to
30 C (59 F to 86 F). The unmixed powder should be kept at room temperature, 15
to 25 C (59 to 77 F), refrigerated after mixing, and discarded after 14 days.

DOSING: Cefprozil is taken once or twice daily, depending on
the nature and severity of the infection. The recommended adult dose is 250-500
mg twice daily for 10 days. Pharyngitis and tonsillitis are treated with 500 mg
once daily.

The maximum dose for ear infections and sinusitis in children 6 months to 12
year old is 30 mg /kg/day in 2 divided doses given every 12 hours (not to exceed
1000 mg/day).

ppharyngitisand tonsillitis, in children (2 -12 years old) are treated with
15 /kg/day in two divided doses every 12 hours while skin infections are treated
with 20 mg/kg/day (not to exceed 1000 mg/day).

DRUG INTERACTIONS:Probenecid
(Benemid) may increase the blood concentration of cefprozil by decreasing
excretion of cefprozil by the kidney. This interaction is sometimes used to
enhance the effect of cephalosporins.

Combining cefprozil with aminoglycosides (for example, tobramycin) produces
additive bacterial killing effects but also may increase the risk of harmful
effects to the kidney.

Exenatide
(Byetta) may delay or reduce the absorption of cephalosporins. Cephalosporins
should be administered one hour before exenatide.

CCefprozil may cause false test results with some tests for sugar in the
urine.

PREGNANCY: There are no adequate studies of cefprozil in
pregnant women..
However, studies in animals suggest no important effects on the fetus.

NURSING MOTHERS: Small amounts of cefprozil are secreted in
breast milk,
but the effect on the infant is unknown.