Just a quick heads up on a KB article we just published. When you deploy a virtualized app to an App-V v5 client using ConfigMgr, as part of the process ConfigMgr removes the Publishing Servers from that client. This is by design but it may cause some confusion if you’re not expecting it.

Have you guys seen an issue with 5.0 where refreshing the client doesn't pull down new packages, instead you have to Restart-Service AppVClient and then it refreshes fine (but again anything you add, it wont see until the client restarts).