The Gold Standard In Nootropics

Nootropics are substances that enhance learning and memory, while being extremely safe and protective of the brain. The nootropic concept was coined by Corneliu Giurgea in 1972 to describe an entirely new type of substance that did not fit into any existing classification.

Giurgea’s quote above captures the idea that our brains have not yet evolved to handle the much more complex world that we now live in and that we cannot wait passively for the brain to improve on its own. Nootropics help remove some of the biological limitations and shortcomings that came about from humans evolving in a much different world.

To be considered a nootropic, a substance must meet ALL of the following characteristics:

Enhance learning and memory

Have few side effects and extremely low toxicity

Protect the brain from physical or chemical injury like concussions, barbiturates or scopolamine

Enhance the firing mechanisms of neurons

Prevent the disruption of learned behaviors and memory formation from conditions which tend to disrupt them, such as electroconvulsive shock or hypoxia.

*Amphetamines like Adderall and wakefulness-agents like Modafinil are NOT considered nootropics.

Nootroo is a once-daily capsule containing a blend of synergistic nootropics that enhances energy and focus for 6-8 hours and beyond. Nootroo was designed from the ground up to bring the purest, most powerful, and safest ingredients available, into a single capsule. With Nootroo’s commitment to being the Gold Standard in nootropics, you know you have the best.

“After I took one this morning I was compelled to sight read classical Mozart for piano. It was so random and my skill was so effortless.”

-Jerilyn S, Musician and Technologist

“I’ve been taking it everyday and I’m feeling very sharp. I’ve also been able to cut back on my coffee consumption.”

-Chad F, CEO Fudali Apparel

“Wow! I didn’t think I would notice it, but I definitely am much more productive when taking Nootroo.”

-Jacquelyn A., Founder of Street Candy

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Ingredients and Instructions

Nootroo comes in two different formulas, a Gold formula and a Silver formula. The two formulas differ in the main ingredient. In the Gold is Noopept and in the Silver is Phenylpiracetam. Both then contain citicoline (Cognizin brand), L-theanine (Suntheanine brand), and a caffeine pterostilbene cocrystal (PURENERGY). The pills are alternated between, one day Gold, and the next day Silver. The Gold formula uses the naturally occurring flavonol, quercetin, to color the capsule yellow.

Studies also show Noopept to stimulate the expression of Nerve Growth Factor (NGF) and Brain-Derived Neurotropic Factor (BDNF) in the hippocampus and cerebral cortex. The hippocampus is the region of the brain responsible for the formation of memories and consolidation of short-term memory to long-term memory. BDNF is a protein that is crucial in determining the quantity of new neurons the brain can create, as well as regulating growth, survival and, differentiation of existing neurons.9)” We showed that the nootropic drug increases expression of neurotrophic factors in the hippocampus. Our results are consistent with the hypothesis that neurotrophin synthesis in the hippocampus determines cognitive function, particularly in consolidation and delayed memory retrieval. Published data show that neurotrophic factor deficiency in the hippocampus is observed not only in advanced Alzheimer’s disease, but also at the stage of mild cognitive impairment (predisease state). In light of this our findings suggest that Noopept holds much promise to prevent the development of Alzheimer’s disease in patients with mild cognitive impairment. Moreover, therapeutic effectiveness of Noopept should be evaluated at the initial stage of Alzheimer’s disease.” http://link.springer.com/article/10.1007%2Fs10517-008-0297-x

Phenylpiracetam has also been shown to be effective in increasing physical endurance, adaptation and resistance to cold. 13) “Carphedon is a phenyl derivative of nootropil and is effective in increasing physical endurance and cold resistance, and is used for amnesia treatment.” Analyst. 1999 Nov;124(11):1559-62. PMID: 10746314.

L-Theanine

L-theanine is an amino acid found in green teas and is well known for its ability to calm a person down without making them tired. 17)Kimura, Kenta; Ozeki, Makoto; Juneja, Lekh Raj; Ohira, Hideki (2007). “L-Theanine reduces psychological and physiological stress responses”. Biological Psychology74 (1): 39–45.doi:10.1016/j.biopsycho.2006.06.006.PMID16930802.. L-theanine has also been shown to improve cognition 18)Park, Sang-Ki; Jung, In-Chul; Lee, Won Kyung; Lee, Young Sun; Park, Hyoung Kook; Go, Hyo Jin; Kim, Kiseong; Lim, Nam Kyoo et al. (2011). “A Combination of Green Tea Extract andl-Theanine Improves Memory and Attention in Subjects with Mild Cognitive Impairment: A Double-Blind Placebo-Controlled Study”. Journal of Medicinal Food14 (4): 334–43.doi:10.1089/jmf.2009.1374. PMID21303262. Theanine has also been shown to induce alpha waves in the prefrontal cortex, in a way that is similar to the waveform that appears during meditation. While L-theanine works great on its own, when combined with caffeine, their synergistic relationship has been shown to boost mood and cognitive performance. 19)Park, Sang-Ki; Jung, In-Chul; Lee, Won Kyung; Lee, Young Sun; Park, Hyoung Kook; Go, Hyo Jin; Kim, Kiseong; Lim, Nam Kyoo et al. (2011). “A Combination of Green Tea Extract andl-Theanine Improves Memory and Attention in Subjects with Mild Cognitive Impairment: A Double-Blind Placebo-Controlled Study”. Journal of Medicinal Food14 (4): 334–43.doi:10.1089/jmf.2009.1374. PMID2130326220)Haskell, Crystal F.; Kennedy, David O.; Milne, Anthea L.; Wesnes, Keith A.; Scholey, Andrew B. (2008). “The effects of l-theanine, caffeine and their combination on cognition and mood”. Biological Psychology77 (2): 113–22.doi:10.1016/j.biopsycho.2007.09.008.PMID18006208.21)Raloff, Janet (September 29, 2007).“Distracted? Tea might help your focus”.Science News172 (13): 206.doi:10.1002/scin.2007.5591721319. “John J. Foxe of the Nathan S. Kline Institute for Psychiatric Research in Orangeburg, N.Y., and his colleagues recruited 16 people for tests of attentiveness on four days. Before testing, each individual drank a glass of water. On 3 days, the drink was spiked with 100 milligrams of theanine, 60 mg of caffeine, or both. The theanine dose was equivalent to that in 4 to 5 cups of tea, and the caffeine translated to about 2.5 cups of tea. In the difficult tests, participants watched a computer screen and pressed a button when a designated shape appeared on the side of a busy visual field to which an arrow had previously pointed. Participants’ accuracy differed little between days when they got water alone or with only one additive. Accuracy improved dramatically, however, on the day that they got the theanine-caffeine combination. The attention benefit lasted throughout the 3 hours of testing.”22)Owen, Gail N.; Parnell, Holly; De Bruin, Eveline A.; Rycroft, Jane A. (2008). “The combined effects of L-theanine and caffeine on cognitive performance and mood”. Nutritional Neuroscience11 (4): 193–8.doi:10.1179/147683008X301513.PMID18681988.23)Einöther, Suzanne J.L.; Martens, Vanessa E.G.; Rycroft, Jane A.; De Bruin, Eveline A. (2010). “L-Theanine and caffeine improve task switching but not intersensory attention or subjective alertness”. Appetite54 (2): 406–9.doi:10.1016/j.appet.2010.01.003.PMID20079786.24)Giesbrecht, T.; Rycroft, J.A.; Rowson, M.J.; De Bruin, E.A. (2010). “The combination of L-theanine and caffeine improves cognitive performance and increases subjective alertness”.Nutritional Neuroscience13 (6): 283–90.doi:10.1179/147683010X12611460764840.PMID21040626.25)Kelly, Simon P.; Gomez-Ramirez, Manuel; Montesi, Jennifer L.; Foxe, John J. (2008). “L-theanine and caffeine in combination affect human cognition as evidenced by oscillatory alpha-band activity and attention task performance”. The Journal of Nutrition138 (8): 1572S–1577S. PMID18641209.

Caffeine Pterostilbene CoCrystal

PURENERGY is a next generation form of caffeine that provides a sustained energy boost over a significantly extended period of time while using less caffeine than a standard cup of coffee. This cocrystal form of caffeine has been shown to have statistical significance for fatigue and concentration after 6 hours, whereas normal caffeine lasts about 3 hours.

” We showed that the nootropic drug increases expression of neurotrophic factors in the hippocampus. Our results are consistent with the hypothesis that neurotrophin synthesis in the hippocampus determines cognitive function, particularly in consolidation and delayed memory retrieval. Published data show that neurotrophic factor deficiency in the hippocampus is observed not only in advanced Alzheimer’s disease, but also at the stage of mild cognitive impairment (predisease state). In light of this our findings suggest that Noopept holds much promise to prevent the development of Alzheimer’s disease in patients with mild cognitive impairment. Moreover, therapeutic effectiveness of Noopept should be evaluated at the initial stage of Alzheimer’s disease.” http://link.springer.com/article/10.1007%2Fs10517-008-0297-x

“Carphedon is a phenyl derivative of nootropil and is effective in increasing physical endurance and cold resistance, and is used for amnesia treatment.” Analyst. 1999 Nov;124(11):1559-62. PMID: 10746314

Raloff, Janet (September 29, 2007).“Distracted? Tea might help your focus”.Science News172 (13): 206.doi:10.1002/scin.2007.5591721319. “John J. Foxe of the Nathan S. Kline Institute for Psychiatric Research in Orangeburg, N.Y., and his colleagues recruited 16 people for tests of attentiveness on four days. Before testing, each individual drank a glass of water. On 3 days, the drink was spiked with 100 milligrams of theanine, 60 mg of caffeine, or both. The theanine dose was equivalent to that in 4 to 5 cups of tea, and the caffeine translated to about 2.5 cups of tea. In the difficult tests, participants watched a computer screen and pressed a button when a designated shape appeared on the side of a busy visual field to which an arrow had previously pointed. Participants’ accuracy differed little between days when they got water alone or with only one additive. Accuracy improved dramatically, however, on the day that they got the theanine-caffeine combination. The attention benefit lasted throughout the 3 hours of testing.”

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Nootroo™ and SmoothCaffeine™ are Trademarks of Nootroo LLC. Suntheanine® is a registered trademark of Taiyo International, Inc. Cognizin® is a registered trademark of KYOWA HAKKO BIO CO., LTD. PURENERGY™ is a trademark of Chromadex, Inc., Patents: See:www.ChromaDexPatents.com. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Nootroo is for adults aged 18 and older. If you are pregnant or undergoing treatment for a medical condition, please consult your physician before taking Nootroo. Phenylpiracetam and noopept are not vitamins, minerals, amino acids, herbs or other botanical, or dietary substances for use by man to supplement the diet by increasing the total dietary intake. Nootroo contains high purity research chemicals intended for use in neuroscience research only.