To gather information on the benefits of computer-assisted instruction and other special learning interventions for exceptional children, this study investigated the performance of 12 children (aged 6-12 yrs) with attention deficit hyperactivity disorder (ADHD) on a computerized immediate feedback t...

Administered one of the beta blockers propranolol (5 or 20 mg/kg) or atenolol (5 or 20 mg/kg) or the alpha-2 agonist clonidine (20 or 100 ?g/kg) in the drinking water to pregnant rats over Gestation Days 1-21. Prenatal exposure to the drugs did not alter the beneficial effects of enriched rearing o...

Differences and similarities between the sexes has long been an area of curiosity and
inquiry. Historically, research into sex differences in cognition has found differences favouring
women in verbal tasks and men in visuospatial tasks. The visuospatial task that has consistently
produced the larges...

Schizophrenia is a complex and severe mental disorder characterized by positive, negative and cognitive symptoms. Characteristic behavioral alterations reflecting these categories of symptoms have been observed in many animal models of this disorder, and are consistent with those manifested in the c...

Altered functioning of the glutamate system during critical periods of development is believed to play a role in various neurodevelopmental disorders, such as schizophrenia. Prepulse inhibition (PPI) of the acoustic startle response is deficient in people with schizophrenia. This study investigated ...

Epilepsy research relies heavily on animal models that mimic some, or all, of the clinical symptoms observed. We have previously described a new developmental rat model of epilepsy that demonstrates both behavioural seizures and changes in hippocampal morphology. In the current study we investigated...

The present study examined the effects of neonatal exposure to serial low dose injections of the glutamate agonist, domoic acid (DOM), on learning and memory in two spatial memory tasks in the rat. Neonatal Sprague Dawley rats were given single daily injections of low dose DOM (20 microg/kg) over po...