This study analyzed 12 autism subgroups, but our informatics method can explore other meaningful divisions of autism patients, and can further be applied to reveal precise genetic associations within other phenotypically heterogeneous disorders, such as Alzheimer’s disease. Graphical abstract

ConclusionFindings revealed ratings of anxiety in youth with and without autism spectrum disorder facing surgery varied by reporter and setting, highlighting the importance of using multiple reporters in research of youth with autism spectrum disorder in the perioperative period. Furthermore, while results showed group differences in premedication patterns and induction compliance, groups did not differ in level of negative behavior change after surgery. Future research can examine how individual differences in youth with autism impact anxiety in the perioperative setting and degree of behavior change postprocedure.

Please note the NIH Neuroscience Series lecture on Monday, December 11, 2017 at noon in the Porter Neuroscience Research Center, Room 620, Building 35, has been cancelled due to bad weather and flight cancellation.
NIH Neuroscience Series Seminar
The brain is one of the most fascinating and complex systems in the body. It controls sensory perceptions, emotions, and actions and makes it possible to form memories and learn highly specialized behaviors. Changes in the connectivity and function of neurons underlie disorders such as autism and schizophrenia, which pose significant challenges to today's society. The aim of Dr. S...

BACKGROUND: The reported prevalence of autism spectrum disorder (ASD) has increased markedly in the past two decades. Recent research indicates that children with ASD are at a substantially increased risk of injury mortality, particularly from unintentiona...

ABSTRACT
Neurodevelopmental disorders such as autism spectrum disorders and schizophrenia have an expansive array of reported genetic and environmental contributing factors. However, none of these factors alone can account for a substantial proportion of cases of either disorder. Instead, many gene‐by‐environment interactions are responsible for neurodevelopmental disturbances that lead to these disorders. The current experiment used heterozygous knock‐out mice to examine a potential interaction between two factors commonly linked to neurodevelopmental disorders and cognitive deficit: imbalanced excitatory/inhibitory...

Data reveals just four in ten pregnant women have received the vaccine this year Related items fromOnMedica Flu during pregnancy not linked to child ’s autism risk Antenatal flu drugs not linked to newborn risks Last winter ’s flu vaccination ineffective for over 65s NHS winter plans centre on more flu jabs and A&E staff Parents urged to vaccinate children against flu

We describe our approach to highlight genes relevant to ASD using coalitional game theory on alteration data of 1,965 fully sequenced genomes from 756 multiplex families. Alterations were encoded into binary matrices for ASD (case) and unaffected (control) samples, indicating likely gene-disrupting, inherited mutations in altered genes. To determine individual gene contributions given an ASD phenotype, a "player" metric, referred to as the Shapley value, was calculated for each gene in the case and control cohorts. Sixty seven genes were found to have significantly elevated player scores and likely represent sign...

CONCLUSIONS: Results of our study suggest that these SNPs are not predictors of childhood ASD in the Chinese Han population. The discrepant results suggest the predictor roles of SNPs have to be determined in different ethnic populations due to genetic heterogeneity of ASD.
PMID: 29216786 [PubMed - as supplied by publisher]