I have been on Irinotecan and Cetuximab for the last 13 months. For the recent two months I have felt moderate pain and tingling of my left leg while my right leg and arms are not effected. I'd like to know if any one has or had similar symptoms of pain and tingling. Now I have to take Ibuprofen and Tylenol every 4 hours.

I will start Keytruda treatment this Thur (Mar 14). The pain and tingling have not gone or become less severe, although my last chemo of Irinotecan and Cetuximab was done 2 1/2 weeks (18 days) ago.

What does your oncologist say about it? Does it seems to radiate down your leg from the hip, and if so in the front or the back? Did you have any kind of precipitating event? Does it feel at all electric, or is it a dull bone ache? Is it positional? Is there swelling? It could be many things, including neuropathy, a clot, a pinched nerve, you name it. If you haven't consulted the doctor about it yet, I think you should, and make sure it is taken seriously. No point in being a hero.

I had pain that I would call almost electric--radiating down the front--from a nerve problem, years before CRC. I had wrenched my piriformis muscle, which was putting pressure on an adjacent nerve. Assiduous targeted stretches and so forth did no good. Couldn't sleep without hydrocodone or the like. What finally fixed it was accupuncture, which I think is really great for nerve-related issues.