Abstract

Cadmium-contaminated rice was habitually consumed by local residents in Mae Sot Districk, Tak Province, Thailand. This study aimed to investigate the potential anti-oxidative activity of crude rice oil extracted from cadmium-contaminated rice as an alternative for utilizing cadmium-contaminated rice without compromising their health with hazard risks. The effects of crude rice oil extracted from cadmium-contaminated rice were determined in an in vitro primary human fibroblast (PHF) cell model. Results indicated that crude rice oil extracted from cadmium-contaminated rice exhibited anti-oxidative activities, in terms of preventing oxidative damage on cellular mitochondrial activity, down-regulation of SIRT1 mRNA, and up-regulation of MMP-2 in PHF cells in vitro. It might be possible that SIRT1 down regulation is related to MMP-2 up-regulation, which could delay aging and promote tissue remodeling in PHF cells. However, specific mechanisms for the regulation of these processes remain to be identified. This study demonstrates crude rice oil extracted from cadmium-contaminated rice exhibited the potential of anti-oxidative activity, which can be used for pharmaceutical and cosmeceutical use.

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