Comedian Dave Coulier stars as the even-keeled host Dave, whose signature catchphrase was "Cut—it—out!"; which was a catchphrase Coulier would later bring to the comedy series Full House. The show also features a cast of kooky archetypal characters, such as the shrill, plastic-fantastic party-girl Diz Aster (Diz McNally), the clueless reporter Angela "Scoop" Quickly (Jill Wakewood), the caustic newshawk Hern Burford (Marty Schiff), Professor Gravity (who was later re-used in the radio sketch Ask Dr. Science), and Waldo, the bespectacled mad inventor (David Stenstrom). Also on the set was a box-like computer called the HA-HA 3200 that was supposedly the sketch and joke writer for the show.

The show featured comedy sketches on recurring themes by the Duck's Breath Mystery Theatre, appealing to viewers from the 5–12 age bracket, interspersed with animation by Spectre Productions.

Let's Eat – a food segment where Dave goes out to restaurants across the country for what he hears to be "The World's Best". If it matches the claim, Dave presents the "Let's Eat Trophy" (a gold cup with novelty chattering teeth) to the owner or chef of the restaurant.