BACKGROUND:
Most descriptions of chromosomal length are based upon the
concept of centiMorgans, a notion derived from rates of
recombination. These descriptions usually do not mention physical
length. However, at least one text provides a statement suggesting
that, regarding human chromosomes, centiMorgan length tends to
correspond to physical length.
"Thus, one can think of centiMorgans as a rough unit of
distance along the chromosome, although the relation to physical
distance is not truly linear because regions vary somewhat in
recombination potential." p204, Principles of Medical Genetics;
Gelehrter and Collins, 1990.
I have accumulated approximately 40 articles wherein
chromosome length is reported and wherein male/female length
differences are reported in terms of centiMorgans.
QUESTION:
Is the Gelehrter and Collins quote accurate? In other words,
although not precisely linear, does physical length tend to
correspond to centiMorgan length?
CONCLUSION:
I would appreciate receiving comments, anecdotes, and citations
that help answer my "centiMorgan versus physical-length" question.
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Thank you,
Teresa C. Binstock, Researcher
Developmental & Behavioral Neuroanatomy
B140 The Children's Hospital
1056 E. 19th Avenue
Denver CO 80218 USA
Teresa.Binstock at UChsc.edu