BACKGROUND
Aspirin has been recommended for the prevention of major adverse cardiovascular events (MACE, composite of non-fatal myocardial infarction, non-fatal stroke, and cardiovascular death) in diabetic patients without previous cardiovascular disease. However, recent meta-analyses have prompted re-evaluation of this practice. The study objective was to… (More)

OBJECTIVE
The identification of sex-based disparities in the use of effective medications in high-risk populations can lead to interventions to minimize disparities in health outcomes. The objective of this study was to determine sex-specific rates of cardioprotective medication use in a large population-level administrative-health database from a… (More)

OBJECTIVES
With steady increases in 'big data' and data analytics over the past two decades, administrative health databases have become more accessible and are now used regularly for diabetes surveillance. The objective of this study is to systematically review validated International Classification of Diseases (ICD)-based case definitions for diabetes in… (More)

Background Information: Limited research has suggested that rural residents are at increased risk of dementia. Objective: The objective of this study is to determine if rural residence is associated with dementia using both cross-sectional and prospective analyses. Methods: In 1991, 1763 community-dwelling adults aged 65+ participated in the Manitoba Study… (More)

Read the related research by Brendan McIntosh and colleagues on pages e102–13. Funding: Sonia Butalia is supported by clinical fellowships from the Canadian Institutes of Health Research (CIHR) and the Alberta Heritage Foundation for Medical Research (AHFMR). Doreen Rabi is supported by a Population Health Investigator award from AHFMR and has project… (More)