Applications/Dilutions

WB: Approx. 140 kDa band observed in NIH3T3 lysates (calculated MW of 141 kDa band according to human NP_005210.3 and 139 kDa band according to mouse NP_031884.1).

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Human.

Packaging, Storage & Formulations

Storage

Store at -20C. Avoid freeze-thaw cycles.

Buffer

0.5 mg/ml Tris (pH 7.3) and 0.5% BSA

Preservative

0.02% Sodium Azide

Concentration

0.5 mg/ml

Purity

Immunogen affinity purified

Alternate Names for DIAPH1 Antibody

DIA1

diaphanous homolog 1 (Drosophila)

hDIA1

homolog) 1

LFHL1FLJ25265

Background

This gene is a homolog of the Drosophila diaphanous gene, and has been linked to autosomal dominant, fully penetrant, nonsyndromic sensorineural progressive low-frequency hearing loss. Actin polymerization involves proteins known to interact with diaphanous protein in Drosophila and mouse. It has therefore been speculated that this gene may have a role in the regulation of actin polymerization in hair cells of the inner ear. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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