Oxiracetam may enhance memory, concentration, and learning ability. It also acts as a mild stimulant that may improve and restore both physical and mental energy.

What Is Oxiracetam?

Oxiracetam is a potent and popular nootropic that has been shown to enhance a broad range of cognitive processes such as memory, learning capacity, attention, and even verbal fluency.‍

It also acts as a mild stimulant that may increase mental energy, alertness, and motivation.‍

Developed in the 1970s, oxiracetam is a synthetic derivative of piracetam, the original nootropic. Though its chemical structure and mechanisms of action are similar to those of piracetam, oxiracetam is more potent.

Its stimulant properties, which are similar to those of phenylpiracetam, are powerful enough to promote wakefulness without significantly interfering with normal sleep patterns.

Oxiracetam has been studied as a potential treatment for memory loss related to Alzheimer’s disease and other neurological conditions. Clinical trials involving aged patients with cognitive decline indicate oxiracetam may be useful in dementia treatment, and there is even clinical evidence that it can help restore memory.‍

Research suggests that oxiracetam is safe and effective in long-term therapy,‍and may promote and preserve brain health.‍

Though there is no documented research on oxiracetam’s effect on young, healthy human subjects, it is a popular nootropic believed by many to enhance memory, learning ability, and overall cognition regardless of age or cognitive condition.

Oxiracetam has not been explicitly approved for any specific use by the USFDA. Oxiracetam is currently unregulated in the US, Canada, Australia, and the UK.

Benefits and Effects of Oxiracetam

Oxiracetam offers a broad range of nootropic benefits, including the following:

Improved Memory

Oxiracetam’s potential as a memory booster is one of its best known and most studied properties.

Both animal studies‍ and clinical trials on adults with age-related cognitive decline‍ indicate that oxiracetam can improve memory in general, enhancing both memory formation and retention and exerting a significantly positive effect on the speed of recall.‍

There are no studies on how oxiracetam affects users with normal cognitive ability, but anecdotal evidence indicates that it acts as a powerful memory boosting nootropic, particularly useful to students taking exams or studying logic-intensive subjects such as math.‍

Animal studies on healthy rodents appear to support these reports.‍

Learning Enhancement

Both animal studies‍ and research involving dementia patients‍ indicate that oxiracetam can improve learning ability. This effect may be due to oxiracetam’s ability to improve the speed of both memory formation and recall.

Concentration and Focus

Anecdotally, oxiracetam is reported to improve overall concentration and focus, making it easier to learn for extended periods of time without waning interest or attentiveness.‍

Oxiracetam’s cognitive enhancement effects combined with its mild stimulant properties make it attractive to individuals looking for a combination of focus and energy.

Enhanced Verbal Fluency

In studies on elderly subjects with primary or multi-infarct dementia, oxiracetam supplementation was shown to stem symptoms of cognitive decline with a particularly marked positive effect on verbal fluency and verbal learning.

Neuroprotectant

Research suggests that oxiracetam may have a significant neuroprotective effect that could potentially block the brain damage associated with Alzheimer’s disease and other forms of dementia.

In animal studies, brain trauma typical of neurological disorders was modeled by introducing neurotoxins known to impair memory formation. The studies indicated that animals given pre-treatment with oxiracetam were resistant to neurotoxicity.

In further testing, oxiracetam was also found to alleviate blood-brain barrier dysfunction and protect against ischemic stroke in rats.‍

Mild Stimulant and Promotes Wakefulness

Oxiracetam is a cholinergic, or substance which releases or responds to the neurotransmitter acetylcholine, and as such acts as a mild psychostimulant

In animal testing, it was shown to promote arousal and inhibit sleep.‍

Studies also indicate that it may promote wakeful alertness by enhancing blood flow to and within the brain, improving energy metabolism.‍

How It Works

While its exact mechanisms of action are not completely understood, oxiracetam’s actions are similar to those of other racetam-class drugs, which enhance cognitive function by stimulating specific neurotransmitter receptor sites and directly modulating the production and release of certain neurotransmitters.‍

Modulates Cholinergic and Glutamatergic Systems

Oxiracetam affects both the cholinergic and glutamatergic systems and directly modulates the release of their respective neurotransmitters, acetylcholine and glutamate.

Both of these neurotransmitters are crucial to memory, learning, and overall cognitive function. This action is similar to that of other racetams, including piracetam, but oxiracetam’s effect is more potent and long-lasting.

Enhances Neuronal Communication

Oxiracetam has also been shown to enhance neuronal communication in the hippocampus, the part of the brain that regulates emotion, memory, and the autonomic nervous system, by affecting lipid metabolism and stimulating the release of D-aspartic acid.‍

Both of these actions have the effect of improving neural signaling, which is closely associated with enhanced memory, cognition, and motivation.

Acts as a Mild Stimulant

Oxiracetam is known to act as a mild central nervous system stimulant.

This effect may be attributable in part to the fact that it is an ampakine.‍

Ampakines are compounds that interact with the glutamatergic AMPA receptors. Ampakines are classed as stimulants but appear to lack many of the classic adverse side effects, such as sleeplessness and feelings of nervousness, that are strongly associated with other stimulants such as amphetamine, caffeine, and methylphenidate (Ritalin).‍

Dosage

Dosage recommendations for oxiracetam, based on human studies, range from 1200–2400 mg per day, split into two or three doses.‍

Though studies using higher cumulative daily doses of oxiracetam have shown no adverse effects,‍ it is recommended to begin with the lowest effective dosage and gradually increase as needed.

For maximum cognitive enhancing effects, oxiracetam should be taken one hour before a learning activity. Research suggests that it may also be beneficial to take oxiracetam regularly for at least five days before peak performance is established.

Attempting to bypass the benefits of regular usage by taking an initial high dose of oxiracetam is an approach that should be considered with caution. While the concept behind high initial doses is to deliver maximum effects in minimum time, there is no documented evidence that a single high dose will provide maximum benefits. High doses also significantly increase the possibility of unwanted side effects such as headaches.

Oxiracetam is water soluble and mixes readily, therefore it can be taken in either capsule or powder form, with or without food.

It is absorbed from the gastrointestinal tract, reaching peak levels within 1–3 hours of ingestion. It has been shown to cross the blood-brain barrier within an hour of ingestion, and it has a relatively long half-life of 8–10 hours.

Stacking

Oxiracetam works exceptionally well as a cognitive enhancer and mild central nervous system stimulant, both on its own and in combination with other supplements.

It’s important to remember that when racetams are stacked their individual effects may be magnified.

Oxiracetam and Choline Stack

It’s essential to maintain sufficient choline in the system when taking oxiracetam or any racetam-class nootropic, so it’s typically recommended to include a good choline source in your daily regimen.

Maintaining sufficient choline will not only help maximize the effect of oxiracetam, but it will also go a long way toward eliminating headaches, which are the most commonly reported side effect.

1x–2x per day

750 mg Oxiracetam

300 mg Alpha GPC

Oxiracetam and Pramiracetam Stack

Oxiracetam stacks particularly well with other racetams.

When stacked with pramiracetam, it can enhance and extend the powerful cognitive enhancement effects of both supplements, and the mild CNS stimulation it provides can improve feelings of alertness and mental energy.

1x–2x per day

750 mg Oxiracetam

300 mg Pramiracetam

Oxiracetam and Aniracetam Stack

When stacked with aniracetam, which like oxiracetam is an ampakine, the powerful cognitive enhancement and mild stimulant properties of both supplements work very well together.

The distinct mood-elevating and anxiety-lessening effects of aniracetam create an effect that users describe as mellow and pleasant.

An example oxiracetam and aniracetam stack may look like this.

1x–2x per day

750 mg Oxiracetam

750 mg Aniracetam

Side Effects

Oxiracetam is generally well tolerated, and no serious side effects have been reported, even when taken at high dosages.‍[39]‍[40]

The most commonly reported unpleasant side effect of oxiracetam is a headache, which is true of all racetam class nootropics. Racetam related headaches are usually associated with either high dosage or choline depletion, so adding a good choline source to your regimen or reducing the amount of oxiracetam ingested can often eliminate the problem.‍

Because it does have mild stimulant properties, oxiracetam could potentially interfere with normal sleep cycles if taken too late in the day.

Side effects of insomnia and nervousness, while rare, have occasionally been reported.‍ These effects can generally be avoided by taking oxiracetam earlier in the day or reducing the dosage.

Closing Thoughts

Oxiracetam is a powerful synthetic nootropic with a proven track record of cognitive enhancement backed by decades of research. Clinical trials indicate that it can enhance memory formation and retention, increase learning ability,‍ and improve verbal fluency;‍ it is also a mild stimulant that has been shown to increase alertness,‍ and it has neuroprotective properties that can help keep the brain healthy.

Oxiracetam is known to be safe and non-toxic even at high doses, and it is associated with virtually no serious side effects.‍

It works well on its own and in combination with other supplements and is considered by many to be a worthy component of any nootropic stack.

Though there are no documented studies on oxiracetam’s effects on young, healthy subjects, it is a popular nootropic with a strong following among students and others seeking sustained mental energy for processing information over extended periods of time.

If you’re looking for a safe, reliable nootropic to give your energy, motivation, and general cognition a boost, oxiracetam may be one to try.

Production

FAQ

A peptide that I purchased recently has less powder in it than others I’ve gotten. Does this mean it doesn’t have the right MG?

Peptides due to their nature come in a variety of sizes and shapes. Normally after the lyophilization process has completed we have a peptide that is in a perfect cake. However there are times when it may break in transit or simply appear differently. This is no way effects the quality or potency of the product. It is simply an aesthetic issue. While we do try to always present a product that looks perfect, on occasion this isn’t possible. Proteins such as LR3 are very large in size and due to the requirement of a buffer will appear larger in size than a mod grf or ghrp. This is also normal.

If A Peptide Is 98% In Purity Then What Is The Remaining 2%?

The purity level indicated on a COA is simply a measurement of aminos that made it into the proper chain to form the peptide. The left over 2% are simply aminos that, for what ever reason, didn’t make it into the proper sequence.

What Are The Purity Levels Of The Peptides You Sell?

AP PEPTIDE will never sell a peptide that is less than 98% in purity from our catalog section. Many of our smaller peptide chains are well into the 99% purity range. We have manufacturing abilities that are quite often beyond the scope of smaller companies and therefore are able to achieve very high purity levels. Proteins such as IGF-1 LR3 are always receptor grade and always above 95% purity.

Two Vials Of The Same Peptide Have Different Amounts Of Powder. Does This Mean They Are Different In Milligrams?

Peptides, due to their nature, come in a variety of sizes and shapes. Normally after the lyophilization process has completed we have a peptide that is in a perfect cake. However there are times when it may break in transit or simply appear differently. This in no way effects the quality or potency of the product. It is simply an aesthetic issue. While we do try to always present a product that looks perfect, on occasion this isn’t possible.

Proteins are very large in size and due to the requirement of a buffer will appear larger in size than a mod grf or ghrp. This is also normal

What Are Your Products Used For?

Peptides and Research serums are manufactured and sold to be used in a laboratory research setting. None of our products are intended for, nor are they manufactured for, diagnostic or therapeutic purposes in humans. Strong Peptide reserves the right to require additional verification of proper intent prior to fulfilling orders. Any orders that we feel aren’t for the specific intended purpose laid out in our Terms and Conditions will be denied. Truthfully, if you are asking this question then you shouldn’t be ordering from AP PEPTIDES.