AMY-1 interacts with S-AKAP84 and this protein in the cytoplasm and the nucleus, respectively, and inhibits cAMP-dependent protein kinase activity by preventing binding of its catalytic subunit to A-kinase-anchoring protein (AKAP) complex.

role of AKAP95 in DNA replication by providing a scaffold for MCM2 (zeige MCM2 Proteine)

AKAP95 is a potential carrier protein for active caspase 3 (zeige CASP3 Proteine) from the cytoplasm into the nuclei in apoptotic cells.

This study showed an increase in the level of global DNA methylation (zeige HELLS Proteine) starting in oocytes with diameters around 60 microm, increases in histone h4, and decreases in AKAP95.

a specific role for A kinase-anchoring protein (zeige MYRIP Proteine) 95 in suppressing the expression of the gene encoding tumor necrosis factor-alpha (zeige TNF Proteine), which involved phosphorylation of p105 (zeige NEDD9 Proteine) (also known as Nfkb1 (zeige NFKB1 Proteine)) by PKA

AKAP8 Protein Überblick

Protein Überblick

This gene encodes a member of the A-kinase anchor protein family. A-kinase anchor proteins are scaffold proteins that contain a binding domain for the RI/RII subunit of protein kinase A (PKA) and recruit PKA and other signaling molecules to specific subcellular locations. This gene encodes a nuclear A-kinase anchor protein that binds to the RII alpha subunit of PKA and may play a role in chromosome condensation during mitosis by targeting PKA and the condensin complex to chromatin. A pseudogene of this gene is located on the short arm of chromosome 9.