The developing brain has a symbiotic relationship with the environment. Enriched environments facilitate neural proliferation, enhance cortical growth and facilitate healthy genetic expression. These (enriched) environments also inhibit unhealthy genetic risk factors and down-regulate excessive development of the amygdala– hypothalamus-pituitary-adrenal system. Bullying poses a significant violation of the enriched environment and results various neural changes. The implications of these violations are discussed in terms of these neural changes (changes in neurochemical releases, neural structures as well as changes in neural activation – cortical blood flow, and neural loops) and in psychological terms (violation of four basic needs – attachment, control, self-esteem, self-esteem protection and self-esteem enhancement; and distress avoidance and pleasure maximization). Lastly, the paper focuses on strategies for effective interventions from a neuroscience perspective. Effective therapeutic strategies need to be developed in line with the principles of molecular neuroscience in order to be effective. A bottom up approach to facilitate change is explained in terms of the developing brain and how it relates to neural changes as result of bullying. These neural changes are aspects like neurochemical processes, compromises in neural structure and unique neural networks that resulted due to the violations of a secure environment. Specific guidelines are proposed to facilitate neural proliferation and enhance wellness.