Anjali was born to Usha and Giridharan Nair. She has a daughter Aavni, who acted as her daughter in 5 Sundarikal and Hadiya. She is married to reputed stills photographer and malayalam film director Aneesh Upasana.She had her formal and high school education from a reputed school in Tripunithura. Later, she had her graduation from N.S.S. College in Tripunithura. Anjali started off as a model, before working as a television anchor and acting in advertisements. She then acted in many music albums.