Relistor

"Nov. 2, 2012 -- Safety steps taken in the wake of the fungal meningitis outbreak have worsened drug shortages, raising questions about whether the U.S. must choose between the safety and the availability of crucial medicines.

Relistor

OVERDOSE

During clinical trials of RELISTOR administered
subcutaneously, no cases of methylnaltrexone bromide overdose were reported.

A study of healthy volunteers noted orthostatic
hypotension associated with a dose of 0.64 mg/kg administered as an intravenous
bolus. Monitor for signs or symptoms of orthostatic hypotension and initiate
treatment as appropriate.

If a patient on opioid therapy receives an overdose of
RELISTOR, the patient should be monitored closely for potential evidence of
opioid withdrawal symptoms such as chills, rhinorrhea, diaphoresis or reversal
of central analgesic effect. Base treatment on the degree of opioid withdrawal
symptoms, including changes in blood pressure and heart rate, and on the need
for analgesia.

CONTRAINDICATIONS

RELISTOR is contraindicated in patients with known or
suspected gastrointestinal obstruction and patients at increased risk of recurrent
obstruction, due to the potential for gastrointestinal perforation [see
WARNINGS AND PRECAUTIONS].

Last reviewed on RxList: 10/20/2014
This monograph has been modified to include the generic and brand name in many instances.