Some weeks our fantasy defense rankings are loaded; other weeks are like Week 2, where are D/ST rankings are decidedly not loaded. Top options Jacksonville (vs. Patriots) and Minnesota (@ Packers) have tough matchups (well, maybe not for the Vikings), and very few sleeper options and potential waiver wire streamers stand out. There are still a handful of good teams with favorable matchups heading up our rankings, but things get dicey in a hurry.

It all comes down to how much you trust Week 1 performances, both for offenses and defenses. The Steelers offense was sloppy and the defense racked up a lot of sacks, but do we really trust either performance given the conditions (and extra period) in that game? Likewise, the 49ers turned it over four times against the Vikings on the road, but a home game against the Lions likely means a far different outcome. Is the Saints defense really that bad? Is the Bucs offense really that good?

Injuries could also have a big effect on this week. If Aaron Rodgers (knee) and Marcus Mariota (elbow) are out, their respective opponents (Minnesota and Houston) get nice bumps in value, with the Vikings possibly vaulting all the way up to the No. 1 spot. Overall, this figures to be a frustrating week for many fantasy owners, but if you're willing to take a few chances, you might come out of things unscathed.