Head-to-head comparisons of medication uses, side effects, ratings, and more.

Medrol (methylprednisolone) is very effective for controlling allergic reactions and many types of inflammatory conditions, but it is associated with serious and potentially life-threatening side effects if you have to take it for a long time.

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3.7/ 5 average rating with 66 reviewsforMedrol

Calms down redness and swelling in the eye.

Omnipred (prednisolone acetate) is a steroid used in the eye that is effective for treatment and symptom relief, but with long-term use, it can have some side effects.

Upsides

Medrol (methylprednisolone) is effective for treating a variety of conditions involving the immune system.

Can help improve energy and stimulate your appetite.

Works quickly to provide relief for swelling, rash, asthma attacks, and pain.

Medrol (methylprednisolone) is available in a generic form.

Available as blister packs that organize tablets into specific days and times for easier administration.

Omnipred (prednisolone acetate) works only within the eye, so it will relieve symptoms without having the side effects of oral steroids.

Kicks in relatively quickly to relieve symptoms.

Available in generic form.

Downsides

Medrol (methylprednisolone) can cause unwanted side effects such as mood changes, trouble sleeping, and increase in blood pressure as well as blood sugar at higher doses.

Long-term use can cause problems to your skin, bones, eyes, and place you at a higher risk for infections.

If Medrol (methylprednisolone) is used for more than 2 weeks, you will need to work with a doctor to get off of the medicine by gradually decreasing the dose.

Medrol (methylprednisolone) can cause harm to an unborn baby, so it might not be a good option for pregnant women.

Might cause abnormal growth and development when used in children.

Depending on the condition, you might have to use Omnipred (prednisolone acetate) up to 4 times a day, particularly in the beginning.

If using Omnipred (prednisolone acetate) long-term, may require some monitoring by your doctor.

Contains sulfite, so depending on the severity of your allergy, may not be suitable for those with allergies to sulfite.

Long-term use can lead to increased risk of more serious side effects.