dab1

Official Full Name

Dab, reelin signal transducer, homolog 1 (Drosophila)

Background

The laminar organization of multiple neuronal types in the cerebral cortex is required for normal cognitive function.;In mice, the disabled-1 gene plays a central role in brain development, directing the migration of cortical neurons;past previously formed neurons to reach their proper layer. This gene is similar to disabled-1, and the protein;encoded by this gene is thought to be a signal transducer that interacts with protein kinase pathways to regulate;neuronal positioning in the developing brain. Alternatively spliced transcript variants of this gene have been;reported, but their full length nature has not been determined.