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The epidemiological transition and rapid changes in disease patterns have posed serious challenges to health-care systems and forced difficult decisions about the allocation of scarce resources. Epidemiological information is often required at all levels of health systems, and compilations of mortality and morbidity statistics at the national and subnational levels have been published by many countries for several decades. However, prior to the first global burden of disease (GBD) study, which began in 1992, there had been no comprehensive efforts to provide comparable regional and global...

The epidemiological transition and rapid changes in disease patterns have posed serious challenges to health-care systems and forced difficult decisions about the allocation of scarce resources. Epidemiological information is often required at all levels of health systems, and compilations of mortality and morbidity statistics at the national and subnational levels have been published by many countries for several decades. However, prior to the first global burden of disease (GBD) study, which began in 1992, there had been no comprehensive efforts to provide comparable regional and global estimates and projections of disease and injury burden based on a common methodology and denominated in a common metric.