« Catalytic impairment of succinate dehydrogenase sustains respiration but is unfavorable for proliferation»

par Dr. Doriane LORENDEAU Vesalius Research Center, Leuven, Belgium

IBCP Conference Room level -1

invited by Hélène Cortay.

Succinate dehydrogenase, or complex II, is important for coupling between Krebs cycle and respiratory chain. Mutations of this enzyme trigger neurodegenerative diseases (Leigh syndrome, ataxia) and rare cancers (paragangliomas, pheochromocytomas). This enzyme plays an adversarial role in terms of cell proliferation. Inhibition of its catalytic activity is investigated on metabolism and cell proliferation by combining the tools of molecular biology and metabolomics/fluxomic studies.

Mardi
03 / 11 / 2015
11h00

Conférence IBCP

« Proteogenemics : embracing the real complexity of proteomes »

par Jean ARMENGAUD CEA-Marcoule, DSV-Li2D

IBCP Conference Room level -1

invited by Catherine MOALI.

Proteogenomics is the alliance of genomics, transcriptomics, proteomics and bioinformatics for obtaining an improved annotation of genomes. Today, it is possible to document in a few weeks any biological species with high-throughput omics approaches and interpret the data focusing our attention on the key molecular players. The application of proteogenomics approaches on non-model organisms such as new pathogens, exotic microorganisms, fungi, parasites, plants, invertebrates or vertebrates, allows understanding the specific traits of each organism. Its application to the catalogue of novel proteoforms formed during tumorigenesis (onco-proteogenomics) is of great interest. Mass spectrometers of the latest generation are recording such massive data on proteins that our vision of proteomics changed drastically. Some examples will be given to illustrate the proteogenomics approaches, their applications and perspectives.

LyonSysBio is the yearly international conference organized by BioSyL , the Systems Biology Alliance of Lyon.
Its goal is to promote exchanges between scientists from different fields (biology, mathematics, computer sciences, physics, social sciences…) interested in the analysis of the wealth of data generated by modern biology, as well as the construction of the necessary modeling tools to gain system level thoughtful insights.
In 2015, the conference will be held from the 18th to the 20th of November in Lyon. It will be dedicated to discussions around the 4 following themes: systems immunology, cell differentiation, a systems view on genotype-phenotype relationship and microbiological systems biology. Keynote lectures will be delivered by the following speakers: