Interactive Cinemas
If you've played Resident Evil 4 or God of War, you're no doubt familiar with this gameplay mechanic. For those who are unaware, here's how it works: During some pre-scripted action sequences, you have to tap the buttons that flash onscreen in order to help Spidey through the sequence. Because of the near-impossible reaction-time required for some of these, it's often more a challenge of memorization than anything else.

If you fail to press the button, or perhaps push the wrong button, one of several things may happen:

You may start over from the begining of the cutscene

You might continue on, but lose some health

Or you might start the cutscene over, but take damage with each failure

Or even worse, you might have to restart the mission from an earlier checkpoint

Combos
You can create massive combo attacks by linking together your Fast, Strong, and Web attacks. These can be very helpful for dealing significant damage to a single enemy, or a lot of damamge to many enemies.