Vesicle mediated intracellular transport through the secretory pathway requires the formation of transport vesicles from a donor compartment followed by vesicle tethering and fusion with an appropriate acceptor compartment. The anterograde...

Dartmouth, Earls of Coat of Arms; The armorial bearings of The Right Honourable William (Legge) Earl of Dartmouth (He was third in descent from WIlliam Legge by Elizabeth, his wife, daughter and coheir of Sir William Washington of Packington co:...

Studies of the secretory pathway have revealed a multitude of secretory proteins that depend on the coat protein complex II (COPII) for export from the endoplasmic reticulum (ER) in transport vesicles. Some secretory proteins require protein...

Dartmouth, Earls of Coat of Arms; colored reproduction; Dartmouth family Coat-of-Arms mounted in "Cathedral Hall" of the University Club of Chicago, Illinois; from Francis Dickin Weeks (3-29-80); Dartmouth Class of 1929

Mutations in the Drosophila retinal-specific Phospholipase C (NORPA) cause massive retinal degeneration within five days of constant light exposure. We have previously shown that in norpA mutants persistent complexes between the light receptor...

Post-transcriptional pathways provide a major means of regulating eukaryotic gene expression. Reiterations of the AU-rich element (AURE) located within the 3' UTR of many labile cytokine and proto-oncogene mRNA serve as signals for rapid...

Transport vesicles form at a donor compartment and fuse to an acceptor compartment mediate the movement of cargo proteins within eukaryotic cells from one subcellular compartment to another. COPII vesicles specifically provide the means of...

Monocytes and macrophages play a key role in a number of immune functions including inflammation, antigen presentation and the clearance of microorganisms and free hemoglobin. Two surface receptors which are important for these functions are CD163...

One man is wearing a traditional Native American-style sash under his coat and a watch chain. The second has a watch chain made of paper clips. Individuals, male; Clothing, western-style; Paper clip; Pipe; Watch chain.

Chemical sensing and separation is a constant challenge intriguing many scientists. Through numerous efforts, revolutionary techniques and innovative materials have been successfully developed to solve this old problem. However, a practical but...

Many environmental toxicants found in pesticides, herbicides, and industrial solvents are believed to have deleterious effects on development by disrupting hormone-sensitive processes. Xenopus embryos were exposed to commonly encountered endocrine...

The docking and fusion of cellular membranes plays an essential role in the secretory and endocytic pathways and in organelle inheritance. The homotypic fusion of vacuoles from the yeast Saccharomyces cerevisiae has been used as a model system to...