Hyperpolarized
gas MRI provides high-resolution regional information on lung function,
offering promise as a valuable outcome measure for cystic fibrosis (CF) and
other pulmonary diseases. Using advanced quantitative analyses, we examined
repeatability of 3He MR images of five CF patients over several
weeks. A pulmonologist read the images, and ventilation volume was determined
using an advanced semiautomatic segmentation algorithm. Total ventilation
volume was statistically consistent over time. A pixel-by-pixel analysis,
however, did show statistical differences. Our results indicate that
investigators will need to evaluate the level of sensitivity to use when
applying this technology to disease staging and therapy evaluation.