Custom antibody development

We offer world-leading antibody development platforms based on a proprietary RabMAb® rabbit monoclonal platform, a phase display platform (AxioMx), and a next-generation sequencing platform (NGS-RabMAb®)

This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

Alternative names

CDS 1

Cds1

Cds1 homolog

Checkpoint kinase 2

Checkpoint like protein CHK2

CHEK 2

Chek2

Chk 2

CHK2 checkpoint homolog

CHK2 checkpoint homolog (S. pombe)

CHK2_HUMAN

hCds1

HuCds 1

LFS 2

LFS2

PP1425

RAD 53

RAD53

Rad53 homolog

Serine/threonine protein kinase Chk2

Serine/threonine-protein kinase Chk2

see all

Function

Regulates cell cycle checkpoints and apoptosis in response to DNA damage, particularly to DNA double-strand breaks. Inhibits CDC25C phosphatase by phosphorylation on 'Ser-216', preventing the entry into mitosis. May also play a role in meiosis. Regulates the TP53 tumor suppressor through phosphorylation at 'Thr-18' and 'Ser-20'.

Tissue specificity

High expression is found in testis, spleen, colon and peripheral blood leukocytes. Low expression is found in other tissues.

Involvement in disease

Defects in CHEK2 are associated with Li-Fraumeni syndrome 2 (LFS2) [MIM:609265]; a highly penetrant familial cancer phenotype usually associated with inherited mutations in p53/TP53.Defects in CHEK2 may be a cause of susceptibility to prostate cancer (PC) [MIM:176807]. It is a malignancy originating in tissues of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma.Defects in CHEK2 are found in some patients with osteogenic sarcoma (OSRC) [MIM:259500].