Vitivirus

VIRION

Non-enveloped, flexuous, filamentous, 725-825 nm or more long and 12 nm in diameter.

GENOME

Linear ssRNA(+) genome of 7.6 kb in size. The 5' end is capped and 3' terminus is polyadenylated. Encodes for 5 proteins.

GENE EXPRESSION

The virion RNA is infectious and serves as both the genome and viral messenger RNA. RNA-dependent RNA polymerase (RdRp) is translated directly from the genomic RNA. The other ORFS are transcribed presumably as subgenomic mRNAs (sgRNAs). RBP is a RNA-binding protein.

REPLICATION

CYTOPLASMIC

Virus penetrates into the host cell.

Uncoating, and release of the viral genomic RNA into the cytoplasm.

The viral RNA is translated as a monocistronic mRNA to produce the RdRp (encoded by the 5'-proximal ORF).

Replication occurs in viral factories. A dsRNA genome is synthesized from the genomic ssRNA(+).