After being shot by a sniper while vacationing at a mountain cabin, Chief of Detectives Robert T. Ironside is left paralyzed from the waist down. Confined to a wheelchair, he continues to investigate crime in San Francisco when he is named a special consultant to the SFPD. His efforts are assisted by a staff which included Sgt. Ed Brown, Officer Eve Whitfield, and Marc Sanger.

A young aspiring artist is accused of cattle rustling and Ironside, who has befriended him, comes to his aid. Getting in the way is the artist's father, who doesn't want him wasting his time on something that doesn't make money.

2x25: Not With a Whimper, But a Bang recap: Officer Whitfield (Anderson) is planted as a college journalism major to check on the editor of a college paper and his assistant after a series of bomb threats. The “Glad Bomber,” the name given by students to a clever bomber whose explosives are harmless, may have more lethal intentions in mind, according to Ironside (Burr). Members of the Army Bomb Squad, involved in a personal feud, fail to identify the “Glad Bomber” and Ironside’s fears are realized when a real bomb causes tragedy... read more.

2x24: A Matter of Love and Death recap: Another death of a girl following an illegal abortion forces police to seek a common element in a number of unsolved deaths from the same cause. A reputable obstetrician, Dr. Manners (Ackerman), attempts to aid Ironside (Burr) in the search during which he sends Officer Whitfield (Anderson) to live in a girls’ residence disguised as a brunette. A suspicion that one of the other residents may be the link to the criminal abortionist leads Eve into a trap... read more.

2x23: The Tormentor recap: Pitcher Atkins (Collins) receives calls from an extortionist demanding $100,000 — or else. To put teeth in his threats, the caller hits Atkins in the back with a chemical pellet fired from the stands of the baseball park at the height of a game. Det. Sgt. Brown (Galloway) warns Atkins the sick-minded extortioner is a real danger to the pitcher, his wife (Mobley) and their child. Against Atkins’ wishes, Ironside (Burr) and his staff search old baseball employment files for a possible clue before the man makes good his threats of vengeance if the police are called in... read more.

2x22: Puzzlelock recap: Ironside (Burr) is aware that his longtime acquaintance, Grayson (Oakland), is responsible for the death of his wife, although the slayer’s alibi appears foolproof. An encyclopedic knowledge of police procedure has enabled him to arrange her death to appear the result of an interrupted burglary, A grief-stricken nephew (Cooney) and the unwitting cooperation of servants aid Grayson’s clever plot. Ironside must discover the killer’s Achilles’ heel and bring an admission of guilt... read more.

2x21: A Drug on the Market recap: Widow Karen Martin (Jones-Moreland), terrified by threats against her life in phone calls and by mysterious voices heard through her daily life, asks Ironside (Burr) for help. Her sister-in-law (Shaw) indicates to Ironside she fears Karen may be losing her mind because she suspects her brother (Danton) of attempting to market an imperfectly tested drug. The brother’s assistant (Beir) insists the accusations are groundless and Ironside begins to agree with their suspicions of Karen until she becomes the number one suspect in a slaying... read more.