Cancer type:

Status:

Phase:

This trial is for people with breast, prostate and non small cell lung cancer (NSCLC) that has spread (advanced cancer). The cancer must not have spread to more than 3 areas in the body.

Cancer Research UK supports this trial.

More about this trial

Cancers can sometimes spread from where it started to other parts of the body. This is advanced (or metastatic) cancer. If the cancer spreads to no more than 3 areas in the body, it is called oligometastatic disease.

You have 3 areas or less of cancer spread. But your cancer can’t have spread to more than 2 organs. So for example, you can take part if you have 2 areas of cancer in your liver and 1 area of cancer in your lung but not if you have cancer in your liver, lung and bones

You have finished treatment for your original cancer and it is stable. You must have finished treatment more than 6 months ago if you have breast or prostate cancer (you may be allowed to take part if you are still taking hormone therapy) or 4 months if you have NSCLC

Your doctor thinks the areas of cancer that have spread can be treated with SBRT and they can be seen on a scan

You have had treatment after your cancer spread (including treatments that reached your whole body) unless it was surgery, radiofrequency ablation (RFA) or SBRT, and the cancer in these treated areas is controlled

Your cancer has spread to the brain

You have areas of cancer (metastases) that measure more than 6 cm (5 cm if they are lungs metastases)

Your cancer has come back near the area where it first started (local regional recurrence)

Your cancer is pressing on the spinal cord (spinal cord compression)

You have fluid in the space between the lungs and the chest wall (the pleura) and the layer of tissue that covers the tummy (peritoneum)

You have had the drugs abiraterone, enzalutamide, docetaxel or drugs to stop you from making the male hormone androgen, if you have prostate cancer

Medical condition

You can’t have SBRT for any reason. For example you have certain lung conditions such as interstitial lung disease and you are going to have SBRT to the lungs or you have colitis and are going to have SBRT to the area between your hip bones (pelvis)

You have any other serious medical condition or mental health problem that the trial team think could affect you taking part

Other

You are pregnant

You can’t have scans (such as CT, MRI, bone scan or a PET) for any reason.

Trial design

This is a phase 2/3 trial. The researchers need about 206 people from the UK to take part.

This trial is randomised. The people taking part are put into 1 of the following groups by a computer:

standard care

SBRT and standard care

Neither you nor your doctor will be able to decide which group you are in.

Standard care
You might have:

chemotherapy

biological therapy

hormone therapy

radiotherapy to help with your symptoms (palliative radiotherapy)

monitoring of the cancer

Your doctor can tell you what treatment you may need. It depends on where your cancer is.

SBRT and standard care
You have SBRT on alternate days. The number of treatments you have depend on where your cancer is. It can be up to 8 treatments (over 19 days). And it can take between 20 to 60 minutes each time. This depends on the type of radiotherapy machine used.

Some people might need to have small markers (fiducial markers) put in the cancer before the start of treatment. This is so doctors can track the cancer and direct the radiotherapy to it. Your doctor can tell you more about this.

After you finish SBRT you have standard care. Your doctor can tell you what treatments you may need.

You might also have a type of scan called DMSA scan. This is to check how your kidneys are working. Your doctor can tell you if you need to have this.

You see a doctor regularly at the time you have treatment. This is to check how you are and what side effects you have.

When you finish treatment, you see the doctor after 1 week and then:

every 3 months for 2 years

every 6 months after

You also have CT scans after you finish treatment. How often you have them depend on your cancer. Your doctor can tell you more about this.

You continue to see the doctor and have CT scans for up to 5 years.

Side effects

The hospital trial team monitor you during the time you have treatment and you have a phone number to call them if you are worried about anything. The team will tell you about all the possible side effects before you start the trial.

The side effects you have depend on the area of your body having radiotherapy. Your doctor can tell you more about this.

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