Later that year, Enterprise discovered what would be determined to be a 31st centuryEarth vessel. At that point, Enterprise was a hundred light years from Earth and more than thirty light years from the nearest trade route with no other ships or ships or inhabited star systems for several light years, making the matter of the initially unidentified craft and its Humanpilot a mystery. (ENT: "Future Tense")

The Hirogen pursued a member of Species 8472 across fifty light years. A group of Hirogen ships pursued the prey to Voyager's position; with the nearest ship half a light year away, Chakotay predicted that Voyager would be intercepted within four hours maximum. (VOY: "Prey")

Voyager spent a month crossing a nebula which spanned one hundred ten light years. (VOY: "One")

At the end of that year, Voyager used a quantum slipstream drive to travel three hundred light years before it collapsed. Several months later, the crew revisited this technology and were able to travel another ten thousand light years before the slipstream dispersed. The technology was deemed too dangerous for use after this occurrence and was dismantled. (VOY: "Hope and Fear", "Timeless")

"The Void" was a region in the Delta Quadrant where no star systems existed within a distance of two thousand five hundred light years which could be passed in an instant via a spatial vortex, which was used by Voyager in early 2375. (VOY: "Night")

The light year is the distance that light travels in one Earthyear. It is approximately equal to 9.46e12×1012kilometers, or 5.88e12×1012miles.The exact length of a light year depends on the exact length used for one "Earth year". The IAU uses a Julian year of 365.25 days, while other sources may use a Gregorian year of 365.2425 days, or another year altogether.