The main purpose of this study is to evaluate the safety and feasibility of regenerative therapy with expanded adipose derived stroma/stem cells sue, administered intramuscularly in patients with critical leg ischemia.

Severe peripheral vascular disease not amenable to bypass or angioplasty

Age >40 years old

Normal renal function (creatinine < 1.6)

Non pregnant female

Lifespan > 6 months

Exclusion Criteria:

Age <40 years old

Refusal to give informed consent and/orCognitively disabled

Congestive heart failure or stroke in the last 3 months

History of cancer or myeloproliferative disorders

Proliferative retinopathy

Pregnancy

Positive screening test for HIV, Hepatitis B or Hepatitis C

Buerger patient

Cachexia or predicted impossibility for a biopsy of at least 30 grams of fat tissue

Pregnancy or lactation

Having been non controlled severe pathology

Contacts and Locations

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study.
To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below.
For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01211028