Abstract

It was fully recognized in the older literature that the liver is frequently increased in size, and sometimes tender, in patients with diabetes mellitus.1-3 In fact, in 1885 Pavy4 found liver enlargement associated with diabetes often enough to warrant his postulating a connection between the two conditions. However, in the recent clinical literature there have been relatively few references to hepatic enlargement in diabetes mellitus.5-7, 14, 18, 32, 36 Of more pertinent value in this respect are the reports of animal experiments. Following total extirpation of the pancreas in dogs the liver remains large out of all proportion to the