Primary endpoint

Proportion of patients with complete recovery at 1 month.

Results

In trial A, there was no evidence for a difference in 1-month complete recovery rates with and without HBO [58% compared to 61%; unadjusted odds ratio, 0.90 (95% CI, 0.47–1.71)]. In trial B, complete recovery rates were significantly lower with two than with one HBO session [47% compared to 68%; unadjusted odds ratio, 0.42 (CI, 0.23–0.79)].

Conclusion

In patients with transient loss of consciousness, there was no evidence of superiority of HBO over NBO. In comatose patients, two HBO sessions were associated with worse outcomes than one HBO session.

Notes

Acknowledgments

The study was supported by the Assistance Publique des Hôpitaux de Paris. The sponsor had no role in the study design, data collection, analysis, decision to publish, or preparation of the manuscript. Registration numbers were NCT01100515 for trial A and NCT01099995 for trial B. The authors are grateful to the physicians and nursing staff of Raymond Poincaré Teaching Hospital and to Paris area emergency departments for their valuable contribution.