8.
Rogério Gaspar
October 24th 2013
Where
does
nanotechnology
belong
in
the
map
of
science?
Alan
L.
Porter
and
Jan
You=e,
Nature
Nanotechnology,
(September
2009):
534-­‐536
The
posi:on
of
nanoscience
and
nanotechnology
over
a
base
map
of
science.
Each
node
in
this
map15
is
one
of
the
175
subject
categories
in
the
SCI.
The
size
of
each
node
is
propor:onal
to
the
number
of
nanopapers
published
in
journals
in
each
subject
category
during
the
period
January–July
2008.
Loca:on
on
the
axes
in
this
Kamada–Kawai
algorithm
representa:on
has
no
Faculdade
de
Farmácia
da
Universidade
olouring
to
reﬂect
inherent
meaning:
the
connec:ng
arcs
and
proximity
reﬂect
similarity
based
on
cross-­‐cita:on
paDerns,
reinforced
by
cde
Lisboa
the
clustering
of
subject
categories
into
macrodisciplines
iMed.UL
(Medicines
Research
Ins:tute)

34.
Rogério Gaspar
October 24th 2013
Current and future regulatory challenges
• combination therapy
– The trend for reformulation of old APIs, with advantages of
combined administration on the same delivery system (issues on
quality/stability, PK/PD, clinical, IP, market access)
• potential theranostic approaches
– Combined system that is able to localize to the target
pathophysiology and deliver an appropriate therapeutic agent
(both diagnostic and therapeutic functions)
• “follow-on” products
– A number of unresolved problems will arise if preventive action is
not taken on matters related to old products, previously not
classified as nanoparticles that are in fact colloidal nanoparticulate
systems
Faculdade
de
Farmácia
da
Universidade
de
Lisboa
iMed.UL
(Medicines
Research
Ins:tute)

38.
Rogério Gaspar
October 24th 2013
Nanomedicine
NOW
?
"Converging
today’s
Building
Blocks
to
Ethical
Medicine
-­‐
When
is
Nanomedicine
'NOW'?”
...
the
answer
is
basically...
• it
is
already
here
(for
the
last
30
years)
and
• it
will
improve
clinical
management
performance
– integra:ng
now
diagnos:cs
and
therapeu:cs
under
the
same
technology
plaxorms,
– allowing
a
beZer
performance
by
the
healthcare
system
• ...personalised
(subpopulaEon-­‐driven)
medicine
as
one
of
the
examples...
Faculdade
de
Farmácia
da
Universidade
de
Lisboa
iMed.UL
(Medicines
Research
Ins:tute)

39.
Pharmaceutical Sciences beyond 2020 –
The rise of a new era in healthcare
Faculdade
de
Farmácia
da
Universidade
de
Lisboa
iMed.UL
(Medicines
Research
Ins:tute)