Hi Mogwai. You can run your #'s throughhttp://geneticgenie.org/
and other sites. I don't know much about this either, as I recently got my 23 results, but looking at yours, it seems there's just one ++, which is good. For instance, from what I think I've learned, MTHFR is more impacting if double positive.
Re detox & the CYPs, etc, yes, all the #'s are important; some (or all, I don't know) indicate your body's response to certain medications, etc.
Also, various alleles react with other alleles, depending on their + or - status.
I hope this helps. Someone who knows what they're talking about should come by shortly. =)

Also, various alleles react with other alleles, depending on their + or - status.

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I think Dr. Rawlins is of the opinion that being +/- for both MTHFR C677T and A1298C is one of the worse combinations. I don't know if that view is popular or correct. Mogwai, are you on a methylation protocol? Have you had labs done? With +/-, it seems (and I could be wrong - I'm not one of those smart people who should come along shortly) that some genes may express more than others, and that it varies from time to time.

I think Dr. Rawlins is of the opinion that being +/- for both MTHFR C677T and A1298C is one of the worse combinations. I don't know if that view is popular or correct. Mogwai, are you on a methylation protocol? Have you had labs done? With +/-, it seems (and I could be wrong - I'm not one of those smart people who should come along shortly) that some genes may express more than others, and that it varies from time to time.

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Dr. Lynch on MTHFR.net agrees with Dr. Rawlins by the looks of it. I will check out Dr. Rawlins' website, thanks.

I have flirted with the methylation protocol, but could never tolerate it for very long. This could be down to a number of factors of course, and that's why I'm here.

Labs? What would you suggest? I live in New Zealand, so not everything is easily accessible. My GP is great, though, and he'd be willing to send my blood to the moon and back if it would help me out in anyway.

You have a couple of First Priority mutations which are SHMT and CBS. So you need to see if those are expressed and address those first before getting into adding methyl supps or you may have problems. SHMT is one of the "leaky gut" genes, so especially if you have multiple food intolerances, you should suspect leaky gut and treat for that first. Otherwise, when you start to add methyl supps you'll start experiencing a high need for magnesium and/or potassium. I'm still researching this, but a 4R gut rebuilding program looks like the best way to go.

For CBS, the Heartfixer page has a good protocol which I've successfully used, except I did the Free Thiol diet and no Yasko RNA supps. If you have an expressed CBS and try to take methyl supps you'll experience a stress/anxiety reaction, and that's why you need to treat for that.

Then you get into MTHFR. You have two mutations, so definitely some methylfolate for that. You have both MTR and MTRR so that's a double whammy on B12. So definitely some B12 for that.

For your COMT/VDR combination, Yasko suggests hydroxycobalamin and adenosylcobalamin. If you supplement with methylcobalamin you might experience mood swings.

No BHMTs, so the secondary pathway should be running well. This might help with CBS, as having BHMT mutations can make CBS worse.

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Then the detox SNPs. These mostly pertain to general health, but a couple of them do matter for treating ME/CFS. Those two would be GST and SOD.

CYP1A1 and CYP1B1 detox estrogen, so your SNPs suggest you could be in a state of estrogen dominance, which could lead to estrogen related cancers such as breast, uterine, or prostate for males. You can take supps to lower estrogen and/or eat cruciferous vegetables.

CYP1A2 metabolizes caffeine, so with one mutation, you're running a bit slow.
CYP2C19 metabolizes proton pump inhibitors and Valium. I think this one is an upregulation. I'm +/- like you and wrote in my notes, fast metabolizer. I have problems with those meds unless I get a slow acting version.

CYP2D6 metabolizes 20% of prescription meds including SRRI's. Some of those of those are upregulations and some downregulations, so they may sort of cancel each other out.

SOD2 impacts the mitochondria, so some support may be needed. At least one person on here is reporting an excellent increase in energy with Biotech Extra Energy Enzymes.

NAT detoxes smoke so stay away from that.

You don't have GST, but if you did, you would need to make more glutathione than the average person.

I have links to all this stuff in my signature. So check them out for further details.