This is a pilot trial to see if one or two 40 treatment courses of low pressure hyperbaric oxygen therapy can improve cognition and brain imaging in subjects with either chronic mild-moderate traumatic brain injury (TBI), also known as post-concussion syndrome (PCS) or chronic PCS with post-traumatic stress disorder (PTSD) secondary to blast injury.

One or more mild-moderate TBI's characterized by loss of consciousness due to blast injury that is a minimum of one year old and occurred after 9/11/2001

Absence of acute cardiac arrest or hemorrhagic shock at time of TBI.

Absence of intracranial neurosurgery post-TBI

Disability Rating Scale of 0-3

Negative Michigan Alcohol Screening Test (MAST)

Negative Drug Abuse Screening Test (DAST)

Negative urine toxicology screen for drugs of abuse

Negative pregnancy test in females

Otherwise good health

Less than 90% on the Percent Back to Normal Rating Scale

Exclusion Criteria:

Pulmonary disease that precludes HBOT

Unstable medical conditions that are contraindicated in HBOT

Severe confinement anxiety

Pregnancy

Other pre-TBI neurological diagnoses

Pre or post TBI history of substance abuse

Pre or post TBI history of alcoholism.

Participation in another experimental trial with active intervention.

High probability of inability to complete the experimental protocol.

Previous HBOT

History of hospitalization for past TBI, stroke, nonfebrile seizures, or any seizure history other than seizure at the time of TBI

Past or current history of mental retardation (baseline FSIQ < 71.

Pre/post-TBI history of systemic illness with impact on CNS (P.I.'s decision)

Contacts and Locations

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study.
To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below.
For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00760734