Yes you can. PopupWisdom does not need an installation program, you can simply copy the files to any PC, wherever you want them.

To extract the files without running the installation program, just run any unzip program (like winzip for example) and open the .exe file as if it was a zip file and extract the contents. Or rename PopupWisdomSetup.exe to PopupWisdomSetup.zip and unzip it as normal

I have installed in the normal way PopUpWisdom in several partitions with windows xp pro operating system. Because of i want the portable version is obvious. In my partition C: i have correctly installed the program and I observed one difference with the folder in the portable version .