..Ciclesonide is delivered and deposited in the peripheral region of the lung as a small particle corticosteroid. The aim of the study is to compare the effects of ciclesonide with fluticasone propionate on small airway function in asthma...

..As such, the particular system of coupled genetic oscillators considered here might be a good candidate to provide the first quantitative example of a synchronization transition in a population of biological oscillators...

The efficacy of using impulse oscillometry (IOS) as an indirect measure of airflow obstruction compared to spirometry after exercise challenges in the evaluation of exercise-induced bronchoconstriction (EIB) has not been fully appreciated...

..Altogether our results reveal further aspects in the complexity of phase entrainment in the circadian system, and suggest that the pituitary may host oscillators able to integrate multiple time cues...

A model for circadian oscillations in the Drosophila period protein (PER)

..A similar result is obtained with respect to the rate of PER transport into the nucleus. The results suggest a tentative explanation for the altered period of per mutants, in terms of variations in the rate of PER degradation...

..01 Hz. The study illustrates the potential of laser Doppler flowmetry combined with dynamical systems analysis for studies of both the micro- and macroscopic mechanisms of blood flow regulation in vivo...

Differential expression of the circadian clock in maternal and embryonic tissues of mice

Hamid DolatshadDepartment of Biology, Northeastern University, Boston, Massachusetts, United States of AmericaPLoS ONE 5:e9855. 2010

..These cycles are active in most adult animal cells but little is known about their expression or influence during development...

..We investigated the accuracy of this method using an established mathematical model of oscillometry. First, to determine which factors materially affect the errors of the method, we applied a thorough parametric ..

Current assessment of COPD relies extensively on the use of spirometry, an effort-dependent maneuver. Impulse oscillometry (IOS) is a non-volitional way to measure respiratory system mechanics, but its relationship to structural and ..

A study of the use of impulse oscillometry in the evaluation of children with asthma: analysis of lung parameters, order effect, and utility compared with spirometry

..We present experimental evidence showing that such a separation can occur in hippocampal slices...

Endogenous electric fields may guide neocortical network activity

Flavio FrohlichDepartment of Neurobiology, Kavli Institute of Neuroscience, Yale University School of Medicine, New Haven, CT 06510, USANeuron 67:129-43. 2010

..This significant susceptibility of active networks to EFs that only cause small changes in membrane potential in individual neurons suggests that endogenous EFs could guide neocortical network activity...

Numerical validation of a new method to assess aortic pulse wave velocity from a single recording of a brachial artery waveform with an occluding cuff

..Invasive pulmonary functions allow distinction between respiratory diseases in mice by clinically relevant variables, and should become standard in the functional evaluation of pathological disease models...

Expression of clock and clock-driven genes in the rat suprachiasmatic nucleus during late fetal and early postnatal development

..Recent technology has improved our understanding of these processes, elucidating the anatomic outputs of the SCN, as well as the molecular outputs of both central and peripheral oscillators that mediate observed physiological changes...

Model of transient oscillatory synchronization in the locust antennal lobe

..The results of this real case study show that the computational tool can successfully analyse and quantify the temporal interactions between neuronal oscillators and could be employed to investigate the mechanisms underlying epilepsy...

Predictive equations and the reliability of the impulse oscillatory system in Japanese adult subjects

..Temperature compensation of oscillation period could be simulated if temperature elevation slowed PER nuclear entry or PER phosphorylation. The model makes experimental predictions, some of which could be tested in transgenic Drosophila...

..We show that the control of various oscillatory properties is distributed over the system enzymes in ways that differ among those properties. The models that are described in this paper can be accessed on http://jjj.biochem.sun.ac.za...

Background gamma rhythmicity and attention in cortical local circuits: a computational study

..We suggest that such rhythms accompany states of preparatory attention or vigilance and report simulations demonstrating that their presence can amplify stimulus-specific responses and enhance stimulus competition within a local circuit...

The use of plethysmography and oscillometry to compare long-acting bronchodilators in patients with COPD

In oscillometry, oscillation amplitudes (OAs) embedded in the cuff pressure are drastically affected by a variety of artifacts and cardiovascular diseases, leading to inaccurate arterial blood pressure (ABP) measurement...

Impulse oscillometry may be of value in detecting early manifestations of COPD

Spirometry is used to diagnose chronic obstructive pulmonary disease (COPD). The Impulse oscillometry system (IOS) allows determination of respiratory impedance indices, which might be of potential value in early COPD, although previous ..

Peripheral airway impairment measured by oscillometry predicts loss of asthma control in children

..whether in asthmatic patients with normal forced expiratory volume in the 1st second (FEV(1)) values, impulse oscillometry system (IOS), as a measure of small airway function, contributed additional information to spirometry either ..

Oscillometric blood pressure measurement used for calibration of the arterial tonometry method contributes significantly to error

..Recordings with healthy subjects demonstrate the potential utility of this approach to characterize BP, to detect outlier measurements, and that it does not suffer from bias relative to the conventional oscillometric method...

Assessment of respiratory mechanics by impulse oscillometry in orthopneic patients with acute left ventricular failure

..Stepwise regression indicated significant correlation between the response of Grs to DI and both Grs and FEV1/FVC responses to exercise. The data are consistent with exercise-induced bronchoconstriction being reversed by deep inhalation...

..Furthermore, hyperlipidemic subjects with hypertension showed significantly higher values than those without hypertension. ASI could be a useful predictor of cardiovascular events in hypertensive subjects with multiple risk factors...

Spirometry, plethysmography and impulse oscillometry (IOS) measure different aspects of lung function. These methods have not been compared for their ability to assess long- and short-acting anticholinergic agents...

A new oscillometry-based method for estimating the brachial arterial compliance under loaded conditions

..The available evidence points to the 8-30 Hz activity being essentially antikinetic in character and inversely related to motor processing. Its exaggeration may therefore contribute to the bradykinesia of Parkinson's disease...

..Within this frame, the amplitude of Mayer waves would be determined both by the strength of the triggering perturbations and the sensitivity of the sympathetic component of the baroreceptor reflex...

..The findings demonstrate that metabolic heterogeneity initiated by mitochondrial ROS-induced ROS release is present in the intact heart, and that the redox state of the glutathione pool is a key determinant of loss of DeltaPsi(m)...

..This scaling behavior, also found in the response of the mammalian basilar membrane to sound, signals the operation of an amplificatory process at the brink of an oscillatory instability, a Hopf bifurcation...

Within- and between-day variability of respiratory impedance, using impulse oscillometry in adolescent asthmatics

Lucas N A LemesBiomedical Instrumentation Laboratory, Institute of Biology and Faculty of Engineering, and Microcirculation Research Laboratory, Institute of Biology, State University of Rio de Janeiro, Rio de Janeiro, RJ, BrazilPhysiol Meas 24:11-25. 2003

..01) of abnormal respiratory events, and a consequent normalization of the patients. These findings support the use of the FOT as a versatile clinic diagnostic tool helping SBD diagnosis and treatment...

Research Grants66

..If associated with WTC exposures in a larger, more representative sample, two new and innovative techniques, oscillometry and pulse wave velocity assessment, hold great promise for earlier detection of WTC-related pulmonary and ..

..Comprehensive follow-up of all children to age 2, and those born in 2003 to impulse oscillometry (lOS) testing at age 4 years, will generate regional data on NICU outcomes in an era when extremely small ..

..We anticipate that understanding how olfactory deficits arise from changes in the limbic system associated with many of these disorders, will help us to understand the mechanisms that produce cognitive malfunctioning. ..

..The proposed studies are aimed at the long-term goal of developing therapeutic strategies to prevent or delay the development of diabetes in obese individuals. [unreadable] [unreadable] [unreadable]..

..parasympathetic dysfunction) and easier and less expensive to obtain. The results of these experiments will thereby help develop better clinical approaches to the control and management of diabetic autonomic neuropathy. ..

..Ultrastructural osteoblastic features of cell and nuclei will be examined via histomorphometric analysis of cell area, nuclear area, cell number, cell and nuclei shapes, in which associated fluid components will be identified. ..

..Furthermore, the experiments will establish the foundations for the potential use of the forced desynchronized rat model to study the neural bases of human internal synchronization and intercellular coupling in the SCN. ..

..The Nanoscience Technology Center at the University of Central Florida is lead for this proposal with collaborators from the University of Illinois and CFD Research Corporation, Huntsville, AL. [unreadable] [unreadable] [unreadable]..

..Omg). This proposal will have important treatment implications for improving rates of smoking cessation in hazardous drinkers and will contribute to the understanding of alcohol-nicotine interactions. ..

..Several specific experiments monitoring individual neuronal behavior and simultaneous population activity during bursting and seizing are proposed to probe the hierarchy and structure of synchronization states. ..

..These findings will have further implications for better understanding the visuomotor control deficits associated with aging, and diseased persons with Parkinson's disease, ataxia, and cerebellar deficits. ..

..Oscillating flows and pressures due to nonlinear effects will also have an impact on mass transfer calculations from blood to surrounding tissues. Time varying flows are also implicated in the health of the vessel wall. ..

..The fourth aim is to provide evidence for the validity of self-management outcome measures for use with PD. It is hypothesized that there will be beneficial and lasting effects of rehabilitation for quality of life outcomes. ..

..This study will also provide insight into the potential role of muscle adaptation and bone turnover in increasing bone mass in response to this simple, non-invasive, non-pharmacalogical intervention. ..

..Ultimately, a more thorough understanding of neural processing of natural tactile stimuli could guide corrective procedures for impaired tactile sensation and aid the design of more effective prosthesis. ..

..Because this work will further our understanding of how high-rate neuronal activity is amplified further by the synapse, it may provide insights into diseases involving runaway excitation (e.g. temporal lobe epilepsy). ..