0.57
mg/ml
(Please refer to the vial label for the specific concentration)

Purification

Affinity Purified

Specifications: PDE4A (phospho Ser140) antibody

Full Name

phosphodiesterase 4A

Background

The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family | and PDE4 subfamily. This PDE hydrolyzes the second messenger | cAMP | which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus | by regulating the cellular concentration of cAMP | this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq | Jul 2011]

This antibody detects all known long-form variants of PDE4A | including PDE4A4 | PDE4A5 | PDE4A8 | PDE4Ax when phosphorylated at the PKA phosphorylation site. It will not cross-react with PDE4A phosphorylated at the ERK phosphorylation site. It does not cross-react with other members of the PDE family including PDE4B or PDE4D.

Host

Rabbit

Clonality

Polyclonal

Isotype

IgG

Immunogen

Synthetic peptide corresponding to PKA phosphorylation site on PDE4A long form enzymes. The peptide was synthesized with phosphorylated serine 140 residue in the rat/mouse PDE4A5 variant. This site is conserved in other PDE4A long form variants.

Antigen Species

Human

Species Reactivity

Human, Mouse, Rat, Rabbit

Conjugation

Unconjugated

Storage Conditions: PDE4A (phospho Ser140) antibody

Storage Instruction

-20⁰C for long term storage

Notes

For In vitro laboratory use only. Not for any clinical | therapeutic | or diagnostic use in humans or animals. Not for animal or human consumption.

PDE4A (phospho Ser140) antibody validated data

GTX60930 WB Image

WB using GTX60930 to detect increased phosphorylation of PDE4A6 in short-term FSK stimulation compared to the unchanged amount of PDE4A6 at 87 kDa.