Motoko MaekawaDepartment of Developmental Neurobiology, Tohoku University Graduate School of Medicine, Sendai, JapanPLoS ONE 4:e5085. 2009

..These results suggest the potential benefit of ARA in ameliorating PPI deficits relevant to psychiatric disorders and suggest that the effect may be correlated with augmented postnatal neurogenesis...

Woman scientists in Japan: their situation and goals

Noriko OsumiEPMEWSE, Science Council of Japan, and Division of Developmental Neuroscience, CTAAR, Tohoku University School of Medicine, Sendai, JapanIUBMB Life 58:273-8. 2006

..We further suggest that the reduction of structural integrity of the neural epithelium caused by the loss of Filamin function may also result in formation of the neuronal nodules found in PH patients...

Pax6 is required for production and maintenance of progenitor cells in postnatal hippocampal neurogenesis

..The number of these interneuron subtypes was dramatically decreased in Pax6 heterozygous mutant mice. These results indicate that Pax6 is required for differentiation and/or maintenance of EPL interneurons in the adult mouse OB...

..Our novel findings suggest that dual regulation of proneural genes mediated by Pax6 and Dmrt family members is crucial for cortical neurogenesis. ..

The effects of Fabp7 and Fabp5 on postnatal hippocampal neurogenesis in the mouse

Miho MatsumataDivision of Developmental Neuroscience, United Centers for Advanced Research and Translational Medicine ART, Tohoku University School of Medicine, Sendai, JapanStem Cells 30:1532-43. 2012

..These data suggest that Fabp7 and Fabp5 have differential roles for proliferation and survival of the NSCs/NPCs during postnatal DG neurogenesis...

..The proliferative area in the developing DG was divided into the three germinal matrices (GMs). However, the stage of the progenitor cells in each GM along the GC differentiation process is not clear...

Manipulating gene expressions by electroporation in the developing brain of mammalian embryos

..The combination of these techniques in addition to analysis of genetic mutants will clarify functions of individual genes, gene interactions, and the molecular mechanisms underlying the brain development...

Multiple roles of Sox2, an HMG-box transcription factor in avian neural crest development

Cyclin D2 in the basal process of neural progenitors is linked to non-equivalent cell fates

Yuji TsunekawaDivision of Developmental Neuroscience, United Core Centers for Advanced Research and Translational Medicine, Tohoku University Graduate School of Medicine, Sendai, JapanEMBO J 31:1879-92. 2012

..We demonstrate that Cyclin D2 is also expressed in the developing human cortex within similar domains, thus indicating that its role as a fate determinant is ancient and conserved...

..In this review, we introduce combinatorial methods of WEC and EP, and summarize various applications in developmental neurobiology...

Preservation of cochlear function in Fabp3 (H-Fabp) knockout mice

Jun SuzukiDepartment of Developmental Neuroscience, United Centers for Advanced Research and Translational Medicine ART, Tohoku University Graduate School of Medicine, Sendai, Japan Department of Otorhinolaryngology Head and Neck Surgery, Tohoku University Graduate School of Medicine, Sendai, JapanNeurosci Res 81:64-8. 2014

..Compared with the wild-type mice, the adult mutant mice demonstrated no differences in their vulnerability to acoustic overexposure. These results suggest that Fabp3 deficiency alone does not adversely affect hearing function. ..

..In parallel, Hairy2 expression in the epidermis was regulated by a Su(H)-dependent pathway. These results indicate that NOTCH signaling has dual functions mediated by either Su(H) or Deltex in the avian embryonic ectoderm...

..As one of the persons present in the area at the time of the earthquake, I would like to report how I experienced the 311 disaster in our laboratory in Tohoku University and how this experience has changed my outlook on many things...

Bimodal functions of Notch-mediated signaling are involved in neural crest formation during avian ectoderm development

..We conclude that Mab21l1 expression dependent on PAX6 is essential for lens placode growth and for formation of the lens vesicle; lack of Mab21l1 expression causes reduced expression of Foxe3 in a cell-autonomous manner...

..These results suggest that temporal disappearance of the EGF/EGF-R signaling from presumptive fusion of the nasal prominences is required for morphological change of the epithelial cells leading to the fusion of MNP and LNP...

Takashi NagaseDepartment of Plastic and Reconstructive Surgery, Graduate School of Medicine, University of Tokyo, Tokyo, JapanJ Anat 203:77-88. 2003

..Our data suggest that the HNK-1 epitope synthesized by different GlcATs is involved in migration in the sublineages of the NCCs in the rat embryo, and that GlcAT-P and GlcAT-D mediate different effects on the NCC migration...

..We show that a combination of whole-embryo culture, followed by organ culture, encourages exogenous human mesenchymal stem cells to differentiate and contribute to functional complex structures of the new kidney...

..In conclusion, the present study suggests that a promoter haplotype of IMPA2 possibly contributes to risk for bipolar disorder by elevating IMPA2 levels in the brain, albeit the genetic effect varies among populations...

..Finally, gene network analysis using the currently obtained expression data highlighted cellular growth and nervous system development pathways as potential targets in the molecular pathophysiology of bipolar disorder...

Fabp7 maps to a quantitative trait locus for a schizophrenia endophenotype