The comparative catalytic activity studies of biologically and industrially important compounds such as Xanthenes and bis (indolyl) methanes were evaluated over propylsulfonic acid functionalized SBA-15/SO3H. The material was characterized via standard characterization techniques such as Powder X-ray diffraction, FTIR, Temperature programmed desorption studies of NH3. The catalytic performance of SBA/SO3H under environmentally benign conditions results in high yield of xanthenes compared to bis (indolyl) methanes and finally the mechanism for both the reactions were proposed.