Cooper- our modular OpenSPIM variant. Cooper has three lasers, two cameras, three swappable samples chambers for either: high-NA excitation with 16X or 40X imaging of development or low-NA excitation with 10X index-matched imaging of cleared tissue, and an adaptive extended field of view light-sheet. Cooper is controlled via an Arduino microcontroller and the OpenSPIM framework. Currently installed and operated as part of the University of Colorado Anschutz Medical Campus Advanced Light Microscopy Core. A publication is in preparation.