Can Arizona slow LeSean McCoy? How will Robert Quinn do against Joe Staley? Drew Brees against the Seattle secondary? Those are among my 10 intriguing things this week.

New Orleans Saints
QB
Drew Brees
vs. the Seattle secondary: The Seattle secondary is one of the best in football, but it will be without
Brandon Browner
and Walter Thurmond. That means
Jeremy Lane
and
Byron Maxwell
will play. Look for Brees to attack those two and stay away from
Richard Sherman
.

Seattle Seahawks
LT
Russell Okung
vs. Saints DE
Cameron Jordan
: Jordan has emerged as a force this season for the Saints defense. Okung is a Pro Bowl-caliber tackle, but he's battled injuries this season. Jordan is relentless, so there is no let up ever when playing him.

Houston Texans
WR
Andre Johnson
vs.
New England Patriots
CB
Aqib Talib
: Johnson remains a top-level receiver and Talib has shutdown skills when he is matched up with the best. The problem for Johnson last week was
Case Keenum
. He was off. These two will get after it.

Philadelphia Eagles
RB
LeSean McCoy
vs.
Arizona Cardinals
' second-ranked run defense: McCoy leads the NFL in rushing and the Cardinals are tough to run on. That will make this a fun battle to watch. Can the Eagles spread out the Cardinals and run it like they have against so many defenses?

Eagles WR
DeSean Jackson
vs. Cardinals CB
Patrick Peterson
: Peterson is a top-level corner when it comes to matching up with the opposition's best receiver. He has the ability to take them away. But Jackson will provide a stiff test with his quickness and speed. Peterson is physical, so I would expect him to use that against the smaller Jackson.

DeSean Jackson's quickness and speed will be a challenge for Patrick Peterson. (USATSI)

San Diego Chargers
' offensive line vs.
Cincinnati Bengals
' defensive line: The Chargers had to play last week without left tackle
King Dunlap
, which forced rookie
D.J. Fluker
from the right side to the left side. And he left the game late with a knee injury, that isn't believed to be serious. Whoever starts will have to deal with
Carlos Dunlap
and
Michael Johnson
off the edges. That's tough duty.

St. Louis Rams
DE
Robert Quinn
vs.
San Francisco 49ers
LT
Joe Staley
: Quinn is a candidate to be the Defensive Player of the Year. He is a force off the edge. Staley is a quality left tackle who excels in pass protection.

Can
Washington Redskins
QB
Robert Griffin III
get it going?: There are many who want to see him benched. That's absurd. He is their long-term answer, so he has to play through his troubles. What would it help to sit him down? He just needs to play better and get better protection.

Can the
Kansas City Chiefs
get a pass rush with a hurting
Tamba Hali
and without
Justin Houston
? The last time the Chiefs faced the
Denver Broncos
, they didn't get near
Peyton Manning
. And that was with Hali and Houston. Houston is out this week, and Hali will be playing on a bad ankle. The Chiefs might be forced to blitz more.

Broncos OLB
Von Miller
vs. Chiefs tackles: Miller wasn't a real factor in the first meeting, but he looked good last week against the Patriots. He will move from the right side to the left side, so look for him to cause problems coming off both edges.

Pete Prisco has covered the NFL for three decades, including working as a beat reporter in Jacksonville for the Jaguars. When he's not watching game tape, you can find Pete on Twitter or dreaming of an...
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