Abstract : Cancer is one of the dangerous disease, modern science still struggle with this disease for complete cure without complications. The number of cancer patients’ is increasing day by day. One of the Indian traditional system of medicine, the Siddha medicinal system plays unique role in the treatment aspects of cancer. It declares enormous medicines for curing cancer. Among them Gowri Chinthamani Chendhooram (GCC) is one of the drug mentioned in classical text with anticancer potential and is also considered to be a crown of Siddha system of medicine. To explore the fruits of GCC to the world, it was underwent globally accepted technique. MTT assay for GCC was done on HeLa cell lines. Raising modern science supports the heavy metals usage in cancer treatment. At the end of this preliminary study, GCC found as a potent anticancer medicine on human cancer cells. Further studies with this medicine will pave right way towards safe and potent anticancer medicine.