Statins as a possible cause of inflammatory and necrotizing myopathies

Atherosclerosis, 04/23/2012Padala S et al.

Statins have recently been associated with a variety of inflammatory myopathies including polymyositis, dermatomyositis, and a necrotizing myopathy. The association of statins with necrotizing myopathy is strengthened by the discovery that the serum of some of these patients contains an anti–HMGCR antibody. This suggests that statins can cause or unmask an immune mediated myopathy.