Super Mutant

When you first encounter Super Mutants, you'll feel like you've met the most difficult enemies in the game. Then, when you finally learn how to deal with them, you meet their more powerful cousins -- Brutes, Masters and the like. That's when you'll truly be up for a challenge. Either way, these highly-mutated yellow-colored foes are a bit of a mystery in the game. But you'll still find them everywhere, especially in the downtown area of Washington D.C. As a result, be ready to deal with their variety of weapons, especially their Miniguns, which they use with devastating accuracy. Of course, there's a positive to fighting the Minigun-toting enemies, as you can grab one of those weapons for yourself after killing your first one. Oh, and for their highly mutated Super Mutant Behemoth cousins? Let's just say you really don't want to mess with them until you're ready.