Cyclofructans (CFs) are cyclic oligosaccharides and have recently been developed into a new class of chiral selectors for HPLC and SFC. Stationary phases with native and derivatized CFs bonded to silica gel (SiO2) have been commercialized and they provide exceptional applicability for achiral HILIC separations (native CFs-SiO2) and chiral separations (derivatized CFs-SiO2). For the purpose of more affordable preparative HPLC columns and high throughput analyses in the industry, new stationary phases were developed by bonding CFs to organic porous resins. Compared to SiO2, these organic resins are not pH sensitive and much more cost effective, however they don’t have the mechanical strength of SiO2. Styrene divinylbenzene resins with various functional groups were used as chromatographic supports. For the first time macrocyclic molecules were attached to resins as new stationary phases for HPLC and SFC separations. These newly synthesized stationary phases provided good selectivities in achiral HILIC separations, such as saccharides and nucleosides. Also, they performed well in chiral separations, especially with amine or amino alcohol racemic compounds.