Norco

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Norco

SIDE EFFECTS

The most frequently reported adverse reactions are lightheadedness, dizziness,
sedation, nausea and vomiting. These effects seem to be more prominent in ambulatory
than in nonambulatory patients, and some of these adverse reactions may be alleviated
if the patient lies down.

The following adverse drug events may be borne in mind as potential effects
of acetaminophen: allergic reactions, rash, thrombocytopenia, agranulocytosis.
Potential effects of high dosage are listed in the OVERDOSAGE
section.

DRUG ABUSE AND DEPENDENCE

Abuse and Dependence: Psychic dependence, physical dependence, and tolerance
may develop upon repeated administration of narcotics; therefore, this product
should be prescribed and administered with caution. However, psychic dependence
is unlikely to develop when NORCO (hydrocodone bitartrate and acetaminophen) ® is used for a short time for the treatment
of pain.

Physical dependence, the condition in which continued administration of the
drug is required to prevent the appearance of a withdrawal syndrome, assumes
clinically significant proportions only after several weeks of continued narcotic
use, although some mild degree of physical dependence may develop after a few
days of narcotic therapy. Tolerance, in which increasingly large doses are required
in order to produce the same degree of analgesia, is manifested initially by
a shortened duration of analgesic effect, and subsequently by decreases in the
intensity of analgesia. The rate of development of tolerance varies among patients.

DRUG INTERACTIONS

Patients receiving other narcotics, antihistamines, antipsychotics, antianxiety
agents, or other CNS depressants (including alcohol) concomitantly with NORCO (hydrocodone bitartrate and acetaminophen) ®
may exhibit an additive CNS depression. When combined therapy is contemplated,
the dose of one or both agents should be reduced.

The use of MAO inhibitors or tricyclic antidepressants with hydrocodone preparations
may increase the effect of either the antidepressant or hydrocodone.