Right then the roads are right from Genzano on the 169 towards Oppido
Lucano.
From Oppido head east on the 96bis towards Altamura.
From altamura take the 99 south to Matera.
In Matera enjoy the fantastic scenery (It's where they filmed Mel Gibson's
"The Passion of Christ") and make sure...

Road itself is not requiring any special skills, but the scenery at the lakeside is worth visiting. Would be nice to dive in the area: if they had a bad or a pub down there near the church still open? Who knows?