Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The latter is also associated with loss of nNOS and TH expression but by contrast, presents with increased expression of SP [26], suggesting regional variations in the effects of diabetes on the enteric nervous system.

The absence of dystrophin, as seen in patients with Duchenne muscular dystrophy (DMD) and its animal equivalent the mdx mouse, leads to a significant reduction in skeletal muscle nNOSexpression and in skeletal muscle blood flow (Brenman et al. 1995).

In our patient with poorly controlled diabetes, the reduction in overall neuronal staining was accompanied by a significant loss of nNOS, but not SPexpression, suggesting relatively specific injury to inhibitory neurons.

Most recently, a study of 36 male diabetic patients undergoing gastric resection showed significant loss of nNOS as well as SPexpression; however, there was no information on whether these patients were symptomatic or had impaired gastric motility [20].

As in the human penis, immunohistochemical staining of human clitoral cavernosal tissue has revealedNOS subtype expression, suggesting the involvement of NO in the regulation of clitoral smooth muscle contractility and the development of clitoral engorgement [41].

The central role played by NO suggests that inhibition of inducible NOSexpression would be beneficial but this needs to be demonstrated experimentally, especially because inhibition of endothelial NOS might worsen brain ischaemia.