Oregon Spotted Frogs (Rana pretiosa) are endemic to the Pacific Northwest, with a historic range from southern British Columbia to northern California. Oregon Spotted Frogs are one of the most endangered amphibian species in the Pacific Northwest, with only 24 remaining breeding sites. Populations have dropped by 80–90% due to habitat loss, predatory non-native species (e.g. Bullfrogs, Rana catesbeiana), and invasive grasses. Oregon Spotted Frogs are endangered in British Columbia and Washington, sensitive in Oregon, extirpated in California, and a candidate species under the U.S. Endangered Species Act.

Alliance zoos and aquariums have joined a pilot recovery program for Oregon Spotted Frogs that includes participation in recovery teams, captive rearing, reintroduction, outreach and education, and research. In addition to two Alliance members (NW Trek Wildlife Park, Oregon Zoo), two partners in British Columbia are also raising Oregon Spotted Frogs (Mountain View Conservation and Breeding Centre, Greater Vancouver Zoo). Point Defiance Zoo & Aquarium is providing financial and facilitation support. In 2009, Vancouver Aquarium and Woodland Park Zoo will join the captive rearing program and Vancouver Aquarium will initiate a captive breeding program for Oregon Spotted Frogs.