Targeted Temperature Management (TTM) is a standard of care, but the nuances of the therapy remain controversial. Two landmark studies prompted therapeutic hypothermia guidelines in anoxic encephalopathy patients; then a randomized controlled trial elicited questions regarding the depth of hypothermia or TTM.1-3 Extensive research has also explored other subtleties of TTM, including time to initiation and target temperature. This session will review foundational research and then dive into more recent research addressing questions of timing in TTM: Is faster better?