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Resolution

Or allow access to api2 app to all Windows users which should have access to the Orion web site explicitly (i.e., add users one by one).

Resolution 2

According Websites table the Orion website was configured to (All unassigned) IP addresses, port 80, SSL not enabled. According IIS configuration the site is actually served on specific IP - 10.x.x.x, both http (80) and 443 (https)

To build top menu the Orion website creates self request to FQDN/Hostname which resolves to local loopback interface address and request fails.

Ran IIS Manager and change Orion website binding to All unassigned. That fixed the issue.

Resolution 3

Uninstall SCOM agent that is on the main poller.

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