>100 ng/mL (toxicity possible)100 ng/mL is the lowest reported level associated with toxicity in patients without primary hyperparathyroidism who have normal renal function. Most patients with toxicity have levels >150 ng/mL. Patients with renal failure can have very high 25-OH-VitD levels without any signs of toxicity, as renal conversion to the active hormone 1,25-OH-VitD is impaired or absent.

These reference ranges represent clinical decision values thatapply to males and females of all ages, rather than population-based reference values. Population reference ranges for25-OH-VitD vary widely depending on ethnic background, age,geographic location of the studied populations, and thesampling-season. Population-based ranges correlate poorly with serum 25-OH-VitD concentrations that are associated with biologically and clinically relevant vitamin D effects and are therefore of limited clinical value.

Effective 03Oct - 28Jan14:Total Vitamin D 25-OH, D2+D3<10 ng/mL (severe deficiency) Could be associated with osteomalacia or rickets10-32 ng/mL (mild to moderate deficiency) May be associated with increased risk of osteoporosis or secondary hyperparathyroidism33-100 ng/mL (optimum levels) Optimum levels in the normal population>100 ng/mL (toxicity possible) 100 ng/mL is the lowest reported level associated with toxicity in patients without primary hyperparathyroidism who have normal renal function. Most patients with toxicity have levels >150 ng/mL. Patients with renal failure can have very high 25-OH-VitD levels without any signs of toxicity, as renal conversion to the active hormone 1,25-OH-VitD is impaired or absent.These reference ranges represent clinical decision values thatapply to males and females of all ages, rather than population-based reference values. Population reference ranges for25-OH-VitD vary widely depending on ethnic background, age,geographic location of the studied populations, and the sampling-season. Population-based ranges correlate poorly with serum 25-OH-VitD concentrations that are associated with biologically and clinically relevant vitamin D effects and are therefore of limited clinical value.Effective 10Dec09 – 02Oct12:Total Vitamin D 25-OH, D2+D3<10 ng/mL (severe deficiency) Could be associated with osteomalacia or rickets10-24 ng/mL (mild to moderate deficiency) May be associated with increased risk of osteoporosis or secondary hyperparathyroidism25-80 ng/mL (optimum levels) Optimum levels in the normal population>80 ng/mL (toxicity possible) 80 ng/mL is the lowest reported level associated with toxicity in patients without primary hyperparathyroidism who have normal renal function. Most patients with toxicity have levels >150 ng/mL. Patients with renal failure can have very high 25-OH-VitD levels without any signs of toxicity, as renal conversion to the active hormone 1,25-OH-VitD is impaired or absent.These reference ranges represent clinical decision values thatapply to males and females of all ages, rather than population-based reference values. Population reference ranges for25-OH-VitD vary widely depending on ethnic background, age,geographic location of the studied populations, and the sampling-season. Population-based ranges correlate poorly withserum 25-OH-VitD concentrations that are associated with biologicallyand clinically relevant vitamin D effects and are therefore of limitedclinical value.