Guidelines for Treatment of Pediculosis Capitis (Head Lice)

Guidelines for Treatment of Pediculosis Capitis (Head Lice)
District Health Authority Public Health Services
And
The Department of Health Promotion and Protection
August, 2008
www.gov.ns.ca/hpp
Aug. 2008
Aug. 2008
Table of Contents
Page #
Acknowledgement
Introduction to Pediculosis Capitis
Life Cycle of Head Louse
Transmission of Head Lice
Detection of Head Lice
Misidentification of Head Lice
“No Nit” Policies
-Position Statement on “No Nit” Policies and Mass Screenings
Pharmacologic Treatments
-Proper Use of Permethrin-Based Head Lice Products
-Oral Antibiotic Use
-Position Statement on Use of Oral Antibiotics
-Pediculicidal Treatment Safety
- Safety of Pediculicides in Pregnancy and Breastfeeding
Non-Pharmacological Treatment
-Daily Lice Combing
-“Bug Busting”
Environmental Cleaning
Treatment Failure
Alternative Treatments
Natural Treatment Alternatives
-Position Statement on Use of Tea Tree Oil for Treatment
of Head Lice
Prevention
Summary
Clinical Pearls
Websites of Interest
References
3
4
4
5
5-6
6-7
7
7
8-9
9
9
10
10
10-11
12
12
12
13
13-14
14-15
15
15-16
17
17
18
19
20-23
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Aug. 2008
Purpose
This document and supporting materials are based on an up to date review of the
literature and is a resource for Public Health staff to guide practice with regards to head
lice. The document and supporting materials will be housed electronically with the
Healthy Development responsibility centre of HPP. The head lice team at Capital Health,
Public Health Services, has agreed to periodically provide recommendations for revising
this document and supporting materials based on available evidence to the Healthy
Development RC.
Acknowledgement
Public Health Services would like to acknowledge the contributions of Nicky Corkum
(B.Sc. Biology, B.Sc. Pharmacy) in the compilation of literature for this protocol. Nicky
conducted a comprehensive literature review on the subject, in conjunction with existing
resources from Public Health Services, to create an educational course for the
Dalhousie University Division of Continuing Pharmacy Education on the subject of head
lice.
3
Aug. 2008
Introduction to Pediculosis Capitis (Head Lice)
The beginning of the school year is a stressful time and it often brings added anxiety due
to head lice outbreaks. Families are frequently embarrassed and shocked when they
learn that a family member has head lice.1 Misconceptions and misinformation about
head lice are widespread. The objective of this protocol is to provide useful information
that public health staff can use when assisting families affected by head lice infestations.
Life Cycle of Head Louse
The life cycle of the head louse is depicted in Figure 1. Within 24 hours of mating, the
adult female louse begins to lay eggs; these egg casings are referred to as nits.3,4 The
female louse uses a cement to adhere six to ten nits each day within 1-2 mm of the
scalp near the hair shaft.3,5 Nits are very small and silver-grey in colour.6 Newly hatched
nymphs look like miniature adults and are about the size of a 12-font period or pin
head.7,8 Nymphs can be either red or transparent, depending on the timing of their last
blood meal.7 Nymphs shed several exoskeletons as they develop into adult lice.7 It
achieves adult status in 10 days and the louse has a life span of about 30 days after
hatching61. Adult head lice are about the size of a sesame seed (2-4 mm long12); with
females being slightly larger than males.5,6 Adult lice can camouflage themselves by
changing colour to match their surroundings.6 The claws of head lice in North America
are specifically adapted to grasp hair with a round cross-section shape.3,9 These lice are
anatomically different than the lice endemic to Africa and cannot easily grip the hair or
position the nits on coarse, curly African American hair which has an oval cross-section
shape.9-11 Despite this difference, some lice in the US have adapted and infestations in
African American children are increasing in prevalence.6
Figure 1: Image credit: http://www.healthcare.ubc.ca/lice/opponent.html
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Aug. 2008
Transmission of Head Lice
Extinction of head lice is highly unlikely; infestations are more common during the
summer, although it may seem that September is the peak of outbreaks.5, 6 This
perceived peak can be attributed to increased monitoring.6 Infestation with head lice is
endemic with prevalence of up to 13 % in elementary school children.3, 6 Head lice do not
spread diseases in humans and do not pose a significant health hazard for the infested
person.3, 7, 12
Nymphs and adult lice usually live off the host for up to three days, however, in favorable
conditions they can survive for four days.5,13 Nits cannot hatch off the host at
temperatures lower than those found near the scalp.12 However in optimal conditions,
such as temperatures from 28-32º C and humidity of 70-90%, nits can survive and hatch
after being away from the host for up to 10 days.10 Lice have a blood meal every four to
six hours.10 Even if nits were able to hatch without a host, they would require a blood
meal within hours of hatching in order to survive.14
Head lice cannot hop or fly, therefore, direct head to head contact is the most common
and efficient means of transmission.9, 12 Head lice only live on the head – they do not live
on an other parts of the body43. There is controversy about the likelihood of transmitting
head lice via inanimate objects (fomites).5,12 Lice and nits can be found on fomites, so
measures to disinfect some of these items are recommended.5,9 Head lice do not live on
pets, so treatment of pets is not required.12,15 Please see the Environmental Cleaning
section for further details.
Detection of Head Lice
Although some people may be asymptomatic carriers, the following signs and symptoms
may be present: 9, 10, 16
• Pruritis – requires 2-6 weeks to develop an immune response to an antigen in
lice saliva during the first infestation; however itchiness develops
within 24-48 hours of future infestations
• Sleeplessness
• Red marks
• Excoriations
• Rash
• Rarely: secondary bacterial infections, fever, irritability and lymphadenopathy
Detection combing is four times more accurate than visual examination in the detection
of head lice.12 It is the only reliable method of detecting active infestations.17 This process
requires a bright light, regular comb, lice comb (a special fine-tooth comb available at
any drug store), hair conditioner (white is best, this color makes it easier to see a louse),
paper tissues (white is best), and a plastic bag for garbage8, 55. A magnifying lens may
also be helpful.4
5
Aug. 2008
Steps to detect head lice: 2,4,5,8,18
1. Apply ample conditioner to dry hair, enough to soak from the scalp to the end of the
strands.
2. Remove tangles with a regular comb.
3. Start behind the ears and comb the hair section by section. Separating the hair (with
hair clips) is helpful.
4. Place the lice comb against the scalp and pull to the end of the hair.
5. Check the comb for lice after each pull.
6. Wipe the comb with a tissue each time and look for lice.
7. Place the tissue in plastic bag.
8. Check all the hair over the entire head.
9. Repeat combing for every part of the head at least five times.
10. Once finished, tie the bag with the soiled tissues and throw it in the garbage.
11. If lice are detected and treatment is required, make sure that all conditioner is
washed from the hair prior to treatment.
The only sure confirmation of an active infestation is finding one or more live lice.4,17
Detection is difficult because lice can move 6-30 cm per minute and there are usually
less than 10 live adult lice per infestation.2,12,19 Nits are most often found at nape of neck
and behind the ears, but are difficult to remove because they are firmly attached to the
hair.3,5,19 Although detection of head lice is not confirmed when only nits are found, the
distance of nits from the scalp provides a modest clue.12 Nits found less than 0.6 cm (the
width of the little finger) from the scalp are likely to be viable and may indicate an active
infestation.5,12,15
Over 75% of children, with nits close to the scalp and no live lice, do not develop active
infestations.12,19 Even with optimal scalp conditions, 10-30% of nits do not hatch.20 In a
large trial which screened 1729 children in Georgia for head lice, 50 children had only
nits and were followed for 14 days.20 Of those 50 children, only nine cases (18%)
converted to an active infestation over the observation period.20 The authors noted that
nearly 32% of children with five or more nits close to the scalp converted to active
infestations versus 7% of those with fewer nits.20 Nits found more than 1 cm from the
scalp are not usually viable and those 2 - 5 cm from the scalp are likely to be remnants
of a past infestation, although in warmer climates viable nits can be found more than 20
cm (8 inches) from the scalp.1,5,19
Misidentification of Head Lice
Misidentification occurs frequently leading to unnecessary treatments and exclusions
from school.6 The identification of head lice was so inaccurate in one study that children
without active infestations were excluded from school more often than children with
active infestations.6 Nits can be confused with many other materials including dandruff,
scabs, dirt, sand, lint, residue left from hair spray, hair casts and other debris.3,5,14 Unlike
nits, the materials above are easily removed from the hair shaft.3,14 Confirmation of an
infestation should include questioning about other materials that may have confused the
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Aug. 2008
identification. Post-treatment itching, even 2-3 weeks after treatment, does not indicate
re-infestation.12,17
“No Nit” Policies
Despite the lack of evidence to support efficacy, some school boards still enforce no nit
policies that do not allow children to return to school until all nits and live lice are
removed.2, 5 The Department of Health Promotion and Protection and District Health
Authorities do not support these policies.2 Children should not be forced to miss valuable
class time because of head lice.14 Removal of nits after a pediculicidal treatment is not
required to prevent transmission because only live lice can cause an infestation.14
Complete lice and nit removal have not been shown to produce better outcomes when
used concomitantly with pediculicidal treatment.21 Although nit removal at the time of
treatment is not necessary to prevent transmission, it may decrease future confusion
with detection and decrease the possibility of unnecessary treatments.14 Rather than
requiring children to be lice-free before returning to school, they should be permitted to
return after they have received appropriate head lice treatment.14
When an active head lice infestation is discovered, the person has probably been
infested for at least one month.19 There is no immediate risk on the day of detection.19
These policies are often in place because it is difficult to differentiate between viable and
nonviable nits.9 Dead eggs and empty shells can remain on the hair for up to six months
as the hair grows.1 Since misidentification is very common, no nit policies often result in
inappropriate exclusions from school.5,6 The resulting time lost by children from school
and missed work by parents is substantial.21 “No nit” policies are not based on scientific
or medical evidence, do not effectively control head lice transmission and should not be
recommended.19,22
Public Health Position Statement on No Nit Policies and Mass Screenings
Public Health Services does not support “No Nit Policies” or mass screenings for nits in
schools.
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Aug. 2008
Pharmacologic Treatments
TABLE 1: Pediculicides Available in Canada3,10,12,13,15,16,22-26
Pediculicide
Pyrethrin/Piperonyl
Permethrin
butoxide (PPB)
Kwellada P®
Brand
R&C®
Nix®
Licetrol ®
Pronto ®
Classification
Pyrethrin
Pyrethroid synthetic
Neurotoxic to
Very low
Very low
humans
Lindane
PMS-Lindane ®
Organochloride
Yes
Contraindications
Cautions
Ragweed /
chrysanthemum
allergy
Children ≤ 2 years*
Children < 3
months*
History of seizures,
preterm infants
Patients < 50 kg or
children < 6 years,
pregnancy, breastfeeding,
HIV patients (decreased
seizure threshold),
inflamed skin
Adverse Events
Dermatitis
Restlessness, seizure,
rash, nausea, vomiting,
diarrhea
100% Ovicidal
No
Edema,
erythema,
hypoesthesia,
pruritis
No
No
Yes
Yes
Yes
nd
2 Treatment
Required
In Canada, pyrethrin/piperonyl butoxide and permethrin are indicated for the treatment of
head lice in children ≥ 2 years.24-25 In the US, permethrin is indicated for use in children ≥
3 months of age.26 Despite these governmental approvals, the Centers for Disease
Control (CDC)) suggests that data to support the use of OTC pediculicides in young
children is lacking.15 For children < 2 years, the CDC recommends manual removal of
nits and lice as the initial treatment option.3,15
Pediculicidal products should only be used on people with active infestations.13 It is
important to treat all infested family members and close contacts immediately and on the
same day to prevent reinfestation.1,3-4 Public Health Services and the CDC recommend
treating “probable cases” if nits (and no live lice) are found close to the scalp of a person
that has not been treated with a pediculicide within the last month.2,8,14-15 However, it is
possible to successfully eradicate head lice infestations by treating only those with
confirmed infestations5.
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Aug. 2008
Proper Use of Permethrin-Based Head Lice Products1,24,27
1. If the hair is wet, dry it before using Permethrin.
2. Shake the product bottle well.
3. Apply a sufficient amount of product to thoroughly saturate the hair and scalp,
paying particular attention to behind the ears and the base of the neck.
4. Leave the product on the hair for 10 minutes.
5. Rinse the product off with water and towel dry.
6. Comb hair with regular comb to remove tangles.
7. Use the techniques described in daily lice combing (without conditioner) to remove
dead lice and nits.
8. Repeat the application in 10 days.
None of the non-prescription products available in Canada are 100 percent ovicidal.12
Regardless of the pediculicidal treatment or labeling, the treatment must be repeated in
7-10 days.10,12 During days five to seven post-treatment, 70 - 100% of eggs are not yet
hatched.27 Some experts suggest that 10 days is the optimum period to wait between
treatments.1,27
Many experts now recommend application of all pediculicides to dry hair to avoid dilution
of the product.4-5 When dry, lice spiracles remain open so application of pediculicides to
dry hair is expected to achieve maximum penetration.18 Diluted permethrin has been
shown to be less active than undiluted permethrin and may contribute to permethrin
resistance.7,28 Once the pediculicidal product is rinsed from the hair, it should remain
unwashed for 1-2 days after treatment.15 Families should be encouraged to practice daily
lice combing and carry out environmental cleaning procedures (See Environmental
Cleaning Section Page 10).8,15 Public Health Services suggest that household members
should also be checked for lice at least once per week for three weeks after the affected
persons have received their second treatment.8
Oral Antibiotic Use
Sulfamethoxazole/trimethoprim has been studied for the treatment of head lice in a few
small trials.5 Symbiotic bacteria in the gut of the lice produce B vitamins and are required
for lice survival.5,10,13 It has been proposed that killing these bacteria results in vitamin B
deficiency and death of the lice.5,13 Trials have noted no statistically significant synergism
when this therapy was combined with pediculicidal treatment.10 In addition, concerns
have been raised about the potential for development of resistance and the possibility of
decreasing efficacy of sulfamethoxazole/trimethoprim in other clinical scenarios.12
Evidence to date suggests that no antibiotic given to a human host can effectively cure
head lice, nor is any antibiotic approved for the treatment of head lice in Canada.10,24
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Aug. 2008
Public Health Services Position Statement on Use of Oral Antibiotics
There is very limited evidence to support the use of oral antibiotics; trimethoprinsulfamethoxazole (not approved for this use in Canada) and ivermectin (not available
in Canada) have been studied; for the treatment of head lice. In addition, using oral
antibiotics for this purpose carries some risk of systemic adverse effects plus
increases the potential for creating antibiotic resistance. Therefore, Public Health
Services does not support the use of antibiotics for the treatment of head lice. 44, 48, 50
Pediculicidal Treatment Safety
There are few reports of adverse effects associated with the use of non-prescription
pediculicidal products.17 Systematic reviews and post-marketing surveillance of
permethrin and pyrethrins reveal only minor adverse events.10 Itching, mild burning and
rash can occur after using pediculicidal products and may be treated with topical
corticosteroids with or without anti-histamines.12 It is not advisable to use pediculicidal
products repeatedly as this may contribute to the development of resistance and does
improve eradication rates.28 Public Health Services recommends that if you find live lice
after the second treatment has been done, then repeat the appropriate steps using a
different product (with a different ingredient) to kill the lice. For example, if you used a
product with Permethrin, then choose a different product that has pyrethrins with
piperonyl butoxide. Make sure to do 2 treatments with the new product.43-61
TABLE 2: Safety of Pediculicides in Pregnancy and Breastfeeding3,13,22,29-32
Pediculicide
Pregnancy
Risk
Category
(FDA)**
Details of use in Pregnancy
Hale’s
Lactation
Risk
Category***
Details of Use in
Breastfeeding
Permethrin*
BM
One retrospective study on
the use of permethrin during
pregnancy (n=113) showed
no increase in the rate of
major malformation in babies
born to women who had used
1% permethrin topically.
Permethrin is generally
considered compatible with
pregnancy.
L2
There is no human data
available for the use of
permethrin in lactating
women, however, it is
considered compatible with
breastfeeding. Since minimal
maternal absorption (less than
2%) is expected following
topical application, little
permethrin would be expected
in breastmilk.
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Aug. 2008
Pyrethrin/
Piperonyl
butoxide
PPB*
C
Lindane
BM
There is no data on the use of
PPB in pregnant women,
however little absorption is
expected following topical
application.
Pyrethrin/piperonyl butoxide is
probably compatible with
pregnancy and may be
preferred over lindane in
pregnant women.
Pregnancy is considered a
contraindication to the use of
lindane by some experts,
however, tthere are no reports
linking the use of lindane with
toxic or congenital defects.
Caution is warranted if lindane
is used during pregnancy due
to the potential for
neurotoxicity, convulsions and
aplastic anemia. Lindane is
contraindicated in preterm
infants and caution is required
in children < 50 kg.
Unavailable
Pyrethrin/piperonyl butoxide is
probably compatible with
breastfeeding. There is no
data on the amount of PPB
excreted in human breastmilk;
however, little would be
expected due to minimal
absorption following topical
application.
L4
Breastfeeding is noted as a
contraindication to the use if
F
lindane in many resources.
However, there are no reports
of the use of lindane in
breastfeeding women, so
lindane is considered by some
to be compatible with
breastfeeding. If breastfeeding
women are instructed to wait
four days after discontinuing
lindane use before
breastfeeding, the nursing
infant would likely avoid
lindane exposure.
* The CDC recommends PPB or permethrin as first line agents for the treatment of pediculosis
pubis (pubic lice) in pregnant and lactating women.32
** FDA Pregnancy Risk Category.29
BM - Either studies in animals have not demonstrated a fetal risk but there are no controlled
studies in pregnant women or studies in animals have shown adverse effects (other than
decreased fertility) that have not been confirmed in controlled trials in women in the first trimester
and there is no evidence of a risk to the fetus in later trimesters.
C- Either studies in animals have revealed adverse effects on the fetus (teratogenic, embryocidal
or other) and there are no controlled studies in women or studies in women and animals are not
available. These medications should be given only if the potential benefits outweigh the potential
risks to the fetus.
***Hale’s Lactation Risk Category.30
L2 - Drug that has been studied in a limited number of breastfeeding women without an increase
in adverse effects in the infant and/or the evidence of a demonstrated risk which is likely to follow
the use of this medication in breastfeeding women is remote.
L4 – Drug with positive evidence of risk to breastfed infants or to breastmilk production, but the
benefit from the use of the drug in the breastfeeding mother may be acceptable despite the risk to
the infant (i.e. if the drug is needed for a life-threatening disease)
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Aug. 2008
Non-pharmacological Treatment
Daily Lice Combing
Daily lice combing between pediculicidal treatments is a helpful adjunct and is strongly
recommended.2,8,10 The purpose of daily lice combing is to remove the nymphs that
hatch between pediculicidal treatments.2,8 Lice exhibit various susceptibilities to
pediculicides based on their developmental stage.7 One can expect to find lice at all
stages of development on an infested head, therefore they will die at different times
following pediculicide application.7 The process of daily lice removal (combing) is very
similar to the technique described in the Detection section, except the hair should be
dampened with water, not conditioner. At the end of each session, wash the comb under
the tap. Use a nailbrush or old toothbrush to get between the teeth of the comb. If you’ve
been using tissues to wipe the comb, tie the bag closed and throw it away. Soak the
comb in very hot water for 10 minutes or store in the freezer for 24 hours before using
again.43-60
Electronic lice combs do not appear to offer any advantages over traditional lice combs
since they do not kill or remove nits.14 Anecdotal evidence both supports and refutes the
use of electronic lice combs.33 Vinegar diluted 1:1 with water, acid shampoo, 5% acetic
acid, conditioner and vegetable oils have been reported to help with nit removal.1 There
are few published trials evaluating the efficacy of these products, however they are
unlikely to be harmful.
“Bug Busting”
Manual removal, “Bug Busting”, is a drug-free lice treatment popular in the UK because
of increasing resistance to pediculicides.5 It involves cleaning with regular shampoo,
rinsing, adding a liberal amount of conditioner and intensive combing.33 This process is
similar to that used for detection. As previously discussed, the purpose of combing is to
remove the lice that have hatched since the last combing session.2,8,34 It takes 15-30
minutes per session and is repeated every 4 days for at least 2 weeks or for a total of at
least four sessions.34 If live adult lice are found during any session, then three further
sessions at four day intervals are required until no lice are found for three consecutive
sessions.33-34 For some families, especially those with many members, combing
protocols may be difficult to follow.11
Few published trials exist comparing Bug Busting to pediculicidal treatments and efficacy
results vary considerably.33 Bug Busting is generally considered less effective than use
of pediculicides and should not be the sole treatment for head lice recommended to the
general population.3, 12
12
Aug. 2008
Environmental Cleaning
Lice do not live for a significant period of time off the scalp, thus heroic environmental
cleaning efforts are not necessary.12 Risk of transmission from lice on furniture and floors
is very low, so it is unnecessary to spend a lot of time cleaning beyond vacuuming where
the infested person usually sits or lays.15 Insecticidal sprays have not been shown to be
effective.8, 22 Do not use lice sprays around your home. There is no proof that spraying
will help control lice, and it may harm family members or pets.8, 15, 22
Although fomite transmission is unlikely, items used or worn by infested person during
the three days before treatment, such as linens, blankets, coats, stuffed toys and
clothing should be disinfected.8-9There are several options to rid fomites of the potential
for transmission. If possible, the object should be washed in hot water and dried in a hot
dryer for 20 minutes.8,15 Alternatively, the objects may be stored in a tightly-wrapped
plastic bag for 10 -14 days or placed in the freezer for 24 hours.8,15 Ironing may also
disinfect items that cannot be washed.8 Combs, brushes and barrettes may be soaked
washed in hot soapy water to remove nits and lice and then soaked in very hot water for
10 minutes or soaked in rubbing alcohol or Lysol® for 1 hour.8,15
Treatment Failure
Many therapeutic failures are not the result of resistance, but are more likely the result of
misidentification, treatment non-compliance or reinfestation from contact with another
infested individual.5,14 When evaluating a reported treatment failure, it is important to
confirm several details about the treatment.5 More specifically, the identification,
treatment and treatment method should be confirmed.5 To determine if it is a true case of
resistant head lice, the following inquiries should be made:
• Exactly how the treatment was used 5, 17
• The number of applications 5, 17
• Simultaneous treatment of all infested persons.5, 17
Pediculicidal resistance may result
from7,19:
• Not drying hair sufficiently leading to
permethrin dilution and sub-lethal doses
• Using a pediculicidal product as a
preventative when no infestation is present
• Shedding of the exoskeleton by nymphs
which can occur after exposure to a
pediculicide and may expose the person to
sub-lethal doses
• Pediculicidal overexposure from too
many applications
• Residual effects of permethrin leading to
sub-lethal doses
• Using too little product
If all infested contacts where not treated
on same day, reinfestation may have
occured.1, 4 When assessing a possible
treatment failure, one must keep in mind
that unhatched lice that are enclosed
within nit casings during treatment are
not expected to be killed.2, 17 These
small lice do not indicate resistance, but
are expected to hatch after the first
treatment and appear on the hair before
the second treatment.2, 17, 33
Although resistance to pyrethrins,
permethrin and lindane has been
13
Aug. 2008
documented in other parts of the world, there is little data available regarding lice
resistance in Canada.12 Depending on the area, treatment failure rates vary.5 Resistance
is not clearly defined in the literature. Resistance should be suspected if a pediculicidal
product is properly used and live, active lice (no dead lice) are detected 8-12 hours after
treatment.15 Others define resistance as finding active young and adult lice 12-24 hours
after treatment or when no lice are killed within 24 hours and no other cause for failure
can be elucidated.4,15,33 Re-treatment is not required if live, less active or twitching lice
are found 8-12 hours after a pediculicide treatment.15 In this situation, all remaining lice
should be combed out of the hair and the same treatment should be repeated on the
scheduled day.15
If a true treatment failure is suspected, the person should be retreated with a different
product immediately and again in 10 days.22,27 The literature supports choosing a
pediculicidal product with an active agent from a different pediculicidal class.4,33 It may be
better to use a pyrethrin or permethrin product, even in a resistant case, than to use a
product with less safety data and possible toxicitiy.14 The first line treatments available
on the Canadian market, permethrin and PPB, work by the same mechanism of action
and cross-resistance is possible.3-5 However, some suggest pyrethrins may still be
effective after permethrin has failed.35 In clinical practice in Canada, if a treatment failure
occurs with permethrin, the person is usually directed to treat two more times with a
product that contains PPB. This is also true of the reverse situation. Although widely
reported as a means to overcome resistance, increasing the concentration of permethrin
to the 5% scabicidal product is unlikely to be more effective than 1% permethrin as lice
have been shown to be resistant regardless of the strength used.5,19,21
Alternative Treatments
There are anecdotal reports of using various household chemicals and products, such
as mayonnaise, petroleum jelly, olive oil, margarine and hair gel to treat head lice but
they are not lethal to lice.10,12 There are no published trials to support the efficacy or
safety of these treatments.12 Although petrolatum is the treatment of choice for lice
infestations of the eyelashes and eyebrows, successfully killing lice by smothering can
be difficult.4 The openings to the respiratory system, spiracles, are closed when lice
become wet.5,12 Lice can remain dormant, without oxygen, respiration and muscle
movement, for several hours (anaerobic metabolism).5,28, 47 This dormancy can be
induced in adult lice by refrigeration, water immersion or application of mayonnaise or
petrolatum.18 People may mistake this “simulated death” as a successful treatment
when, in fact, the lice can regain mobility shortly after the product is removed.10,18 In a
laboratory setting, lice are observed for up to 24 hours before concluding that a
treatment is fatal to lice.18 If an occlusive treatment must be used, people should be
instructed to apply a thick coat and leave it on for at least 8 hours.8 One may wish to
apply before bedtime, cover hair with a shower cap overnight, and wash hair with regular
shampoo in the morning. This may suffocate live lice, but the nits will not be affected and
will continue to hatch. You will need to repeat the treatment several times over 2-3
weeks43-60 People should be instructed to combine smothering treatments with daily lice
14
Aug. 2008
combing.8 Tips for easier removal of petrolatum include using Dawn® dishwashing liquid
or Pert® shampoo.13,36
Some people have used natural products such as tea tree oil, other essential oils, and
aromatherapy products to treat head lice. Public Health Services does not recommend
the use of such products because their safety and effectiveness is not yet known.
Other products such as gasoline or kerosene are flammable and toxic. They are
dangerous and are not recommended by Public Health Services.43-60
Cetaphil Gentle Skin Cleanser® (referred to as Nuvo lotion) was used to treat head lice
in a preliminary trial and the overall reported cure rate was 96%.37-38 The author suggests
applying the product and drying it with a hairdryer to form an adherent film on the hair.37
It is suggested that the spiracles are plugged and the lice are smothered.37 The trial had
several methodological flaws, including a lack of randomization, blinding and placebo
control. More data is required before this treatment can be confidently recommended.
Natural Treatment Alternatives
There is a lack of efficacy and toxicity data for essential oil products, particularly with
regular use, resulting in unanswered questions about safety.10-12 Natural products are not
necessarily non-toxic, for example, ylang ylang oil is a potential contact allergen and
anise ingestion has been associated with movement abnormalities, vomiting, nystagmus
and pediatric emergency room visits.5,28,33 There is no data to support the use of tea tree
oil or aromatherapy for treatment of head lice.12
Public Health Services Position on Use of Tea Tree Oil for
Treatment of Head Lice
There is no evidence that tea tree oil products are effective in treating head lice. In
addition, there is no data on the toxicity of such products. Therefore, Public Health
Services does not support the use of tea tree oil products for the treatment of head lice.
55, 56.
HairClean 1-2-3® (Chick-Chack® spray in other countries) is a non-pediculicidal head
lice treatment recently marketed in Canada by Quantum, Inc.9 It is a herbal product that
contains anise oil, coconut oil, ylang ylang oil and isopropyl alcohol.9 The suggested
mechanism of action is a phenomenon referred to as flee response.18 When lice detect
danger, such as a noxious smell, they flee to the base of the hair and hold tightly.18
Alternatively, the lice may flee to the ends of the hair and crawl off to escape the pending
threat.18 The high concentration of anise oil reportedly causes an extreme flee
response.18 Three applications are required at five day intervals.16,39 At each application
the product should be left on the hair for 15 minutes then washed out with regular
household shampoo.16,40
15
Aug. 2008
One manufacturer-sponsored published trial in subjects 6 to 14 years of age, compared
HairClean 1-2-3® to an aerosolized spray marketed in Israel containing permethrin,
malathion and piperonyl butoxide. Subjects were considered infested when one or more
live louse and nits were found in a 3-5 minute combing session. Of 940 people
examined, 199 (21.2%) were determined to be infested and were randomly assigned to
a treatment group. Of these people, 129 (64.8%) reported using the treatment correctly.
Reasons for non-compliance were not reported. Detection sessions were conducted on
days 1 or 2 and 10 days after the first treatment. Failure was defined as detection of live
lice. Both products where reported to be 92% effective. No significant side effects were
reported. One person from each group experienced post-treatment itching.39 Other
manufacturer-sponsored abstracts are available, however the details required to fully
evaluate the evidence are lacking.40
Another non-pediculicidal head lice product, Resultz®, was recently approved by Health
Canada for the treatment of head lice in adults and children 4 years and older.41 It is
marketed by Altana Pharma Inc. and contains 50% isopropyl myristate, an ingredient
commonly found in cosmetic products.41-42 The proposed mechanism of action includes
dissolution of the exoskeleton wax of the lice resulting in dehydration and death.41 A
sufficient amount of product to wet the scalp should be applied to dry hair.41 After 10
minutes, the product should be rinsed with warm water.41 The manufacturer suggests
applying a second application after 7 days to ensure efficacy.41
Details of a study in which 30 people (aged 2 to 59 years) were treated with Resultz®
have been published in poster format.42The trial was not placebo-controlled or
randomized. Infestation was defined as detection of at least one live louse and viable
nits. People were examined at baseline and on days 7, 14 and 21. The product was
applied if live lice were detected during the examination. The product was left on the hair
for 10 minutes, rinsed with water for 10 minutes and combed for 10 minutes to collect
lice. Efficacy was defined as the need for two or less treatments over the 21 day period..
0f the 30 people, one required three treatments and was reported as the only treatment
failure. This person was not lice free at Day 21 and received a standard course of
permethrin.41-42 One person withdrew from the study, but the reason for withdrawal was
not noted.42 Adverse events included itchiness; mild skin irritation and redness which the
authors suggested were worsened by the dry air in Winnipeg. Other available
manufacturer-sponsored abstracts contain scant information making evaluation of
efficacy and safety difficult.41 In one trial, the treatments were reapplied only if lice were
present seven days after treatment.41 Their reported 23% efficacy rate for traditional
comparator products, including permethrin and PPB, is very low while efficacy rates
reported for Resultz® were 62% and 80%.41 Better quality evidence is required to
evaluate the efficacy and safety of this alternative product.
16
Aug. 2008
Prevention
Pediculicidal products should only be used on people with active infestations as they
do not protect from re-infestation.1,13 Prophylactic treatment may perpetuate
resistance and increase the risk of adverse events.1,13 Although most authorities
suggest that only those with live lice should be treated, prophylactic treatment of
bedmates is sometimes recommended; this practice is not supported by Public Health
Services.2,4,22
Several measures can be employed to aid in the prevention of head lice. Public Health
Services recommends parents / guardians check their child’s head regularly: once a
week as part of their routine, after every sleepover and every day during lice outbreaks
at school.8 It is also recommended to keep long hair tied back or braided. Although
cutting the hair may make lice detection easier, short hair does not prevent infestations.6,
11
Children should be taught not to share personal items that are used on their head.
This means things like brushes, combs, barrettes, headbands, elastics, towels, hats,
helmets, toques, and scarves.8, 19 Children should also be taught to put their hats and
scarves in their coat sleeves or backpacks when they take them off at school to prevent
lice transmission.5,8 If your child has been in contact with someone who has lice, you
need to check your child’s head carefully to see if they have caught lice. Head lice
spreads easily, so if one person in the household has lice, others may have it too.
Everyone in the household should be checked on the same day. There is no evidence
that “lice repellant” products decrease the prevalence of head lice.11 Further safety and
efficacy data from well designed in vivo studies are required before repellant products
can be recommended.1, 11, 17 Regular combing with a fine-toothed pocket or lice comb
has been reported to prevent head lice infestations, although there is little reliable
information to support this practice.1, 17
Summary
Research is needed to improve the accuracy of detection and to determine the most
effective treatments for cases with confirmed, active infestations.6 Improved pediculicide
compliance to limit overexposure and prevent the development of resistance is another
area for further research.6 There is also a need for better designed trials to determine the
place of natural products in the management of head lice.
17
Aug. 2008
Clinical Pearls
• Information given to people about head lice by all health professionals must be
similar to prevent confusion, decrease frustration and increase the likelihood of
successful treatment.
• Treat only those who are infested.
• Treat people with nits close to the scalp (and no live lice) only if the person has not
been treated with a pediculicide within the last month.
• All pediculicidal products should be used on dry hair.
• Re-treat all cases in 10 days regardless of the pediculicidal product used.
• Use daily lice combing between pediculicidal treatments.
• Don’t wash the hair for 1-2 days after the treatment is rinsed from the hair.
• Vacuum the floor and furniture where the infested person usually sits or lays.
• Items, such as such as linens, blankets, coats, stuffed toys and clothing, used or
worn by infested person during the three days before treatment should be disinfected.
• Items used near the hair should also be disinfected.
• Insecticidal sprays have not been shown to be effective, pose health risks and
should not be recommended.
• Check school age children for lice once per week, after sleepovers and every day
during an outbreak.
• There is little quality evidence to support the use of any “natural” head lice product
for the treatment of head lice.
18
Aug. 2008
Websites of Interest
Speare, Rick. School of Public Health and Tropical Medicine. James Cook University:
www.jcu.edu.au/school/phtm/PHTM/hlice/hlinfo1.htm
Pollack, Richard. Harvard School of Public Health:
www.hsph.harvard.edu/headlice.html
Canadian Pediatric Society:
http://www.caringforkids.cps.ca/whensick/HeadLice.htm
Summaries UK Clinical Knowledge:
http://www.cks.library.nhs.uk/head_lice/ view_whole_topic_review
References
19
Aug. 2008
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