This Blog is about one person's search for a holistic protocol for ME/CFS (myalgic encephalomyelitis / Chronic Fatigue Syndrome) and Lyme Disease

Wednesday, November 17, 2010

A Multi-B12 Protocol that Works

One of the sad facts of life with Lyme and/or related CFS co-infections is that these infections are known to deplete B12, and subsequently down-regulate multiple biologic processes dependent on B12. So over the past few years I have tried various B12 therapies, along with everything else reported here (salt/c, MMS, self-talk, etc.). However, none of those B12 approaches worked for me, although a series of methyl B12 injections in 2007 helped with energy while I relocated from the moldy east coast to the dry mountain west. I should probably post about that experience separately, getting to a lower mold and drier climate definitely helped my CFS symptoms. But for some reason I did not connect the dots about the B12 at that time. So for another two years I remained B12 depleted... But not anymore, and B12 is definitely helping this time. The difference is a gradual ramp-up B12 protocol that uses multiple forms of B12, along with methyl form of folate, other B vitamins (particularly B6), and several key supplements that support the methylation cycle. The result is calming of the nerves, better detox, and most importantly, better mental clarity, focus, endurance, and more energy. This B12 protocol is a combination of several other B12 protocols. Of all the protocols I have tried over the years and reported here, this is undoubtedly the best so far. I can now work part-time again, even performing mildly demanding mental work. Post-exertion malaise is significantly reduced. And these improvements appear to be stable, now for about six months. I have gone from 25% functional to 40% functional and at times perhaps 50%. This response is huge, the most improvement I have had in over 10 years. But the protocol is more than just taking B12. I am also supporting the most critical metabolic cycles that utilize B12. Read on for the details!

(continued)This is a long post, and I realize some people might not be able to read through it very quickly. So here is the short summary. I have found four relatively inexpensive supplements that together seem to address many of the neurological problems in Lyme/CFS (which I will just call CFS from here on). One of the supplements is the biologically active methyl form of B12. These four supplements have helped multiple people, including myself and several family & extended family members. And the four supplements seem to be synergistic, taking them separately is far less powerful than taking them as a group. Being encouraged by the success of those four supplements, I added two more groups of supplements that support the B12 metabolism, including several critical antioxidant vitamins, minerals, super foods, and additional forms of B12. These all seem to have helped improve the effectiveness of the initial four supplements and in fact may be important in allowing the full ramp-up of B12 doses.

The Goal - Full Restoration of B12 LevelsMy goal is to eventually be able to take a biologically equivalent dose of the active forms of B12 (both methyl and adenosyl). In other words, this protocol accepts that CFS bodies are not processing B12 properly and therefore the protocol seeks to supply all the active form of B12 that the body needs. However, this is easier said than done. With the B12 depleted, only a trickle is in the body, just enough to sustain life. And as we begin restoring that B12, the body tries to restart many biological processes that have been in hibernation. This creates a high need for certain nutrients that are generally depleted in CFS. Therefore the protocol includes other critical supplements to support the core four, including two other forms of B12! Taking all of these supporting supplements has been important in allowing us to continue to increase the dose of B12, in pursuit of the goal of full biological replacement of the depleted and missing B12.

The Theory Behind the Multi-B12 ProtocolThe theory behind this protocol is that the metabolism of B12 has been blocked somewhere. B12 metabolism includes a complicated intake, transport, activation and recycling process, making B12 processing a somewhat fragile part of our metabolism. But B12 is critical for our health, B12 is involved in hundreds of biological processes. Unfortunately B12 can be easily blocked at any step in its intake, transport, activation, recycling, or utilization in the many metabolic processes. The result is that there are many ways B12 can fail in the body. So rather than take many expensive tests and try to find medical or research professionals who understand B12 metabolism and can narrow down my specific B12 problem (there are only a handful of experts and they are expensive), I decided to follow the advice of several well informed CFS patient-researchers and bypass the entire B12 intake-transport-conversion-recycling process by supplementing the active forms. So this protocol is all about getting the activated forms of B12 into the body, bypassing the blockages to B12 utilization, wherever they may exist in the metabolism, and supporting the re-starting of all the processes that are hibernating or on hold due to B12 depletion. And that approach is definitely working.

Early ResultsHow well is this working? Over the past 8 months I have experienced a significant improvement in my longstanding CFS illness due to this intensive B vitamin protocol. I have gone from being able to work 1-2 hours per day and rarely leave the house, to sometimes working half days and being able to go places again for a few hours at a time, with little post-exertional malaise. I do still need rest breaks during the day and must be careful about over-exertion, but the shift is dramatic. I feel like I am back in the 'real world' again, at a lower level of functioning than before my illness, but no longer a complete prisoner to CFS.

My adult daughter with CFS is also experiencing significant improvement on the same protocol. Over the years we have tried various treatments including both traditional drug medicine as well as alternative nutritional and herbal medicine. We have had only very small gains from past treatments. But what we have both experienced the past few months goes beyond anything we have tried before. In my case I have regained the ability to perform mentally challenging tasks, I now sleep soundly through the night and wake up feeling refreshed (usually I have had poor sleep and wake up often, and in the morning feel very tired), and can tolerate foods better, including some carbohydrates that have bothered me in the past, and also can perform low-level physical labor without the usual post-exertional malaise. I can now stand up and walk around again without constantly looking for a place to sit down. Also, I am now working part-time, something I have not been able to tolerate the past 5 years. And the improvements are steady and continuing. There have been some neurological symptom flare-ups but they usually do not last long and generally seem associated with detoxification, immune activation, or starting-up of dormant metabolic processes. Over time the small setbacks have usually been followed by increases in energy, and in fact I have noticed that I tolerate these CFS symptom flare-ups better than before, have enough new energy to get through that without having to stay in bed all day.

The Research Behind the ProtocolThe basis of the B vitamin protocol we are following is research into the role of blockages in the methylation cycle in CFS. This includes the folate cycle and methionine cycle. The theory for the protocol is that a B vitamin deficiency, particularly B9 (folate) and B12 (cobalamin), is either resulting from, or causing, an error of metabolism leading to blocks in the methylation cycle. These blocks cause depletions of critical energy, immune and neurological resources, and in theory can produce all the symptoms of CFS and related disorders. Explaining methylation in detail would take about 40 pages, but the quick explanation is that methylation is to the body what Taxi drivers are to New York City. Critical elements in the transport, and processing of many different molecular passengers in the body.

The nutrients I selected are those that are both theoretically depleted in CFS, and also readily available and affordable. These nutrients are factors in the suspected dysfunctional parts of methylation (folate/methionine) cycle.

Credits for the protocolThis protocol is original, but parts are borrowed from work by others in the CFS patient-researcher community (Dr Vinitsky, Amy Yasko, Rich Van Konynenburg, and a recovered CFS patient 'Freddd,' who I have consulted with over the phone but prefers to be anonymous). Each of these researchers has added important information for this protocol, and those familiar with those protocols will see that. I have also learned that this approach has much in common with the recommendation of Prof. Martin Pall for treating nitric oxide imbalances (the NO/ONOO- hypothesis for CFS). However, this multi-B12 protocol is not strictly following any of those other protocols. This protocol emerged from a careful trial and error process with several CFS patients (including myself and both immediate and extended family members with varying degrees of CFS), along with close study of the basics of the methylation cycle, which showed me that a few important parts of the cycle were not being supported by each of these other protocols. In addition, I am constrained financially to finding an affordable protocol. So this is an attempt to construct a 'real world' workable combination based on the work of these helpful researchers. I am grateful for the willingness of six family and extended family members to try out parts and in one case the full protocol along with me. Their response has encouraged me that this approach is 'on the right track' for CFS and the related conditions.

Could B12 Depletion Produce CFS?The reason for the B vitamin problems are unclear, and may be due to a combination of genetics, infections (Lyme, enterovirus, HHV6, etc), toxins, digestive dysbiosis, enzyme problems, loss of intrinsic factor required for B12 absorption, chronic stress, or even hyper sensitivity to environmental factors such as mold and EMF. In fact all of these can be connected with both CFS and B vitamin deficiency (particularly B12). In addition, several infections proven in research to be common in CFS are known to deplete B12, such as Lyme bugs and gut protozoans. Some medications also deplete B12 including SSRIs and tetracyclines.

At first I did not believe something as simple as a missing vitamin could cause CFS, but a little research showed that in fact B12 loss can cause severe diseases such as pernicious anemia. The book 'Could it be B12?' by Pacholok & Stuart helped me understand the significance of B12 problems, and how many different conditions it can cause. B12 is involved in hundreds of biological processes and a deficiency can cause a wide variety of problems, making B12 problems very difficult to track down. I recommend that book to anyone who has chronic health problems that doctors can not explain, to help them either identify or rule-out B12 deficiency.

The Multi-B12 Protocol - Stage 1Now the protocol itself. The protocol is progressive, eventually utilizing multiple forms of B12 and also a few co-factors essential for the B vitamins to work. The following are the core supplements and the brand and dose we are using. The supplement manufacturer/brand may be critical, these are recommended by many people. I have tried other brands of many of these supplements without this positive effect. Also, I believe all the supplements work together. These are all nutrients required for key stages of the methylation cycle. The B6 is important in getting the full effect, particularly helping calm the nerves. Based on experience with multiple people using stage 1, this should be well tolerated by many CFS patients. I am one of the more sensitive patients, have a hard time with many drugs and supplements, and I have a well documented heavy metals problem including mercury, but have had no problems with stage 1.

1. Active B12 (methylcobalamin), by Jarrow. This type of B12 is active form and supports methylation, is a co-factor in folate metabolism, a co-factor in glutathione production, and also a scavenger. Each person must find their tolerance level for this, I now use a half of a sublingual 5000 mcg tablet 2-3x daily, but had to start with just one quarter of a 1000 mcg tablet (which is 250 mcg) daily and work up to the higher daily doses gradually. There are other brands of methyl B12 that can work, but many are lower-strength. Enzymatic Therapy's product is pretty good, and we had some success with the Vitamin Shoppe generic brand, but nothing compares with Jarrow. The Jarrow product is almost as powerful as Methyl B12 injections (based on my personal experience with both).

2. Ester-C, by American Health. This Vitamin C is slow-release and supports the adrenals as well as being essential to the methylation cycle. I take 1-2 tablets (500-1000mg) daily, in the morning and optionally afternoon if tired. This formula seems to do more than much higher doses of other brands of Vitamin C.

3. Magnesium Chloride by Alta Health. Magnesium is often depleted in CFS (particularly with Lyme co-infection), so supplementing just makes good sense, even without the methylation connection. I take one tablet daily, usually in the morning. The chloride form is usually well absorbed and is a critical co-factor in methylation. This also seems to help digestion.

4. B6 by Solgar (250mg) or Nature's Way (100mg). B6 is critical to B12 metabolism and is used in the methylation cycle. One capsule of Solgar or 1-2 of Nature's Way per day. The Solgar brand is more expensive, but also higher dose. I used Solgar for several weeks and am trying the lower-dose Nature's Way product now, as it is more affordable. There is a small but noticeable difference, Solgar seems a little better, but I don't know yet if that is due to brand or dose differences. Some people report tolerance issues with B6, so those who suspect that should probably start with lower doses. I have had no trouble with any dose in this combination of supplements and believe the B6 is being utilized properly in this combination.

Within 48 hours of starting these four supplements, on just a 1000 mcg dose of methyl-B12, I experienced a complete change in my neuralogic state. This included a huge reduction in a 40 year-long anxiety problem. I am still smiling about that, and that was just the beginning. After selecting this combination, based on a study of the B12-methylation cycle, I learned that several doctors are using B6 and Magnesium, and others are using methyl B12 to treat children with Autism or Asperger's, with great success. So the fact that this is helping with CFS is at least consistent with some clinical experience in related areas.

Continuing the story... Once these supplements were working, after a few weeks, I started noticing that my endurance improved and my immune function seemed better. My continual viral immune response seemed to normalize, and digestion improved. Also, my color returned to normal (skin no longer yellow, teeth now whiter, tongue now red not white, and the rings under the eyes lightened)! But ironically, with these gains I also started getting more recognizable symptoms of B12 deficiency, which I now believe had been present all along but was partly covered by the neuropathy involved in B12 deficiency. Think about that, B12 deficiency produces neuropathy (this is a known fact) which hides the symptoms of B12 deficiency! No wonder this problem can drag on so long without being identified. As the full realization that B12 deficiency was now evident for my CFS, I decided to add supplements to more fully support the methylation cycle and help make up for other deficiencies long-term B12 depletion has probably caused. So that led to Stage 2 of this protocol, the addition of vitamins, including more B vitamins, minerals, and a natural green concentrate.

The Multi-B12 Protocol - Stage 2After about a month, I started adding a few other supplements that are recommended for sustaining the methylation cycle. Many of these supplements are additional B vitamins and some are antioxidants. Some promote nerve health and some (such as the folate) are recommended by other people using various B-vitamin protocols. These seem very important and I tolerate higher doses of B12 while using these.

Here are the sustaining supplements. I arrange these in alphabetical order to help remember to take them all in the mornings. I have included the brand name only where I believe brand makes a difference. If I do not give the dose, I am just taking the recommended daily dosage, or sometimes half of that. These do not all seem equal in importance, I can skip some of them some days without too much effect. But the three in bold are more important.

1. Vitamin A (from fish oil). A natural antioxidant. Alternate days with Vitamin D (due to possible interactions)2.1. Active Vitamin B12 (adenosylcobalamin), called Dibencozide, by Country Life. This is essential to increase energy. This could be in the core supplements, but, I suspect only people with CFS need this while those with Lyme or other related problems without the CFS may not. I take 150 mcg daily (a half tablet). This is another active form of B12, used by the mitochondria in energy production.2.2. Vitamin B complex (naturally balanced). I use a Jarrow product for that, 'B-Right', but probably others would work. Be careful NOT to use a standard B-50 or B-100, those formulas are not balanced and do not seem to have as much positive effect.3. Vitamin D. I use a D3 product. Also I alternate this with Vitamin A, do not take them the same day (there are some possible interactions)4. Vitamin E. I use a Gamma E complex, but probably any good E will work.5. Methylfolate (activated Vitamin B9). Solgar Metafolin ONLY. This is another essential supplement, but it is so strong that I did not include it in the core supplements, because I believe it could give such a strong reaction that people might get discouraged about the protocol. This brand is an activated form of methylfolate patented by Merck. I take 200 mcg per day, some people take up to 800 mcg. But tolerance varies, this amplifies the effect of Methyl B12, so be careful to ramp-up slowly.6. Green nutrients supplement. I have a variety, and probably juicing vegetables would be best. I believe this is an essential part of the protocol, supplying a broad spectrum of natural nutrients while the body repairs and restarts dormant processes. My current favorite green concentrate is 'Perfect Food' by Garden of Life. This makes a huge difference, if I forget to take this, I can tell within a few hours, so I believe there are many critical nutrients for CFS in this supplement.7. Calcium. I have tried herbal calcium and also sometimes Calcium Citrate.8. Omega oils. I take a 3-6-9 product made from Salmon oil.9. Potassium. I take about 1/4 tsp of potassium chloride, although tablets and capsules are available. This may be critical for some people, due to mineral problems involved in health problems related to B12 depletion. Some days I take an electrolyte solution that has potassium and count that as the daily potassium (I take '40,000 Volts' by Trace Minerals Research).10. Trace minerals. I use a product called 'Concentrace' but probably any good quality trace mineral product will work.11. Zinc. I take one 50mg tablet ONE time per week.12. Choline. I take one gelcap daily of Phosphatidyl Choline. This is a key ingredient in the cellular methylation that protects the DNA from damage.

The Multi-B12 Protocol - Stage 3Once the two forms of B12 and the supplements in stages 1 & 2 were helping, I added a third form, the natural form, Hydroxocobalamin. The reason to add this is that H-B12 is known to help with brain function and one lingering symptom on this protocol has been mild brain-fog. In fact it seems that at times the methyl-B12 adds a detox burden, but H-B12 seems to often lift that. This is listed as a stage 3 because I suspect some people might not need this, but for those with lingering brain fog after stages 1 & 2, I believe it might be important.

1. Natural B12 (Hydroxycobalamin). There are only two brands I have found, one by Perque, and the other by ProHealth. We are using the ProHealth brand as it is slightly less expensive (H-B12 is the most expensive of the B12s). As of this posting I am just using 1250mcg of H-B12 daily (one quarter of a 5000mcg tablet), but it is definitely helping.

There is still the cyanocobalamin form of B12 which we have taken in the past, but are not regularly using. This is also a natural form, produced in the liver, but supplementing this produces a cyanide residue that I don't want to deal with right now. However, some people with CFS have used C-B12, and at some point I may try this again.

The Multi-B12 Protocol - Extra Support SupplementsAnd finally, here are a group of useful extra supplements. These are the only other supplements we are using. These are taken as needed.

1. Blue-green algae. I use the Klamath Lake product, primarily to help with sleep. If I wake up too early, one capsule helps me get back to sleep. My daughter uses this as well, for sleep help. This is often recommended for detox and also for ADD, it is very helpful during B12 therapy.2. Oregano oil. This is an amazing product for addressing any viral or bacterial infection. We use this regularly and it seems to often stop a virus. Liquid and gel cap, both work well.3. Olive Leaf Extract. This also is a powerful natural antiviral. I take this every night to help with sleep, and also take extra when I have any viral problems. Liquid or capsule form seem equally effective.4. Chlorella. This seems helpful when there are strong detox reactions. But I can not take it past about 5PM or it can interfere with sleep.5. Guaifenesin. This really helps my daughter with her Fibromyalgia, and seems more effective with the B12 protocol. We are exploring this further as Guai has allowed her to sleep better than she has in years. I tried a full Guai protocol for CFS some years ago with little success, but combined with the B12 protocol this might be worth exploring again.

Where to Buy the SupplementsAs for the supplements, I now buy these supplements online from iHerb.com, as do many people on related B-vitamin protocols for CFS. They have the best prices I have found, shipping cost is low, and they ship quickly. iHerb.com also offers a 'referral fee' so every customer is an 'affiliate.' I know, that can be annoying but that is just how they operate. There is no membership fee, if you buy anything they will give you a code you can use to give other people a $5 discount on their first order and receive a tiny referral fee from each subsequent order. My code is MOP379. If you use that you will get a one-time $5 discount. I think their referral discount system is clever, but of course the goal is to find reasonable prices. So far they have the best prices for these supplements that I have found.

Next StepsNow that this 'Multi-B12' protocol is finally working, I have started to explore some 'next steps' to build on this success. Clearly this type of B12 protocol can only take a person so far. I believe that once the methylation system is working a bit better and B12 levels are normalized, a foundation is set down for further treatment options. Some ideas I am exploring right now are anti-candida protocols, which might finally become tolerable, stronger anti-microbials for Lyme and protozoa co-infections, and a revisiting of some past therapies I have tried that seemed promising. One of the big surprises with this multi-B12 protocol is the enhanced sense of well-being. That may set a foundation for the use of various emotional/spiritual and cognitive healing methods that have seemed promising in the past but now with the B12 may have better ability to help reprogram the brain and the mind/body connection towards healing and recovery.

Final ThoughtsWhen I first studied B12 protocols, I found the many competing recommendations and the complicated science to be quite discouraging. But actually getting a protocol that works was not as difficult as expected. The only parts that I have had to adjust were the doses of methyl B12 and methylfolate (B9). And sometimes I have to take a second Ester-C. Also, while I am exploring different doses of B6 now that is not due to tolerance issues, but just to find the most affordable dose that works. But on the whole, this is a pretty simple protocol that requires minimal adjustments. I am very curious to find out whether this will work for other CFS patients, or those with related conditions, including basic anxiety, Lyme, and issues related to Asperger's.

I am happy to answer any questions about this, I know probably I have not explained things very thoroughly. Eventually I hope to have time to go into more detail, but right now I 'have a life' starting up again, so not much time.

37 Comments:

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Hi Anon,no, I am not worried a bit about the methylfolate because the dose I am taking, 200mcg per day is only 50% of the RDA. That is far from a high dose. I believe the studies are for folic acid, which is harder to metabolize than methylfolate. Also, if CFS patients are depleted in folate, the problems with excess folic acid seem unlikely to occur when supplementing with the active form methylfolate, even if the dose is a little above RDA.

Alex,Good question. The RDA for zinc is only 8mg per day. So 50mg weekly give you 6 days worth of RDA. Given that most CFS patients are sensitive to carbs and many eat a lot of protein, and given that meats are high in zinc, I think that is adequate supplementation to ensure a person is not deficient. Some CFS patients take more zinc daily, but zinc competes for copper and we need levels of copper for arterial wall integrity. Of course each situation is unique and some people may benefit from more zinc. There is also a benefit from a larger weekly dose, as larger zinc doses have a mild anti-parasitic effect. So I am trying to get the benefits without the risks. If a CFS patient is male and has prostate problems though they may need much more zinc. This is a 'middle of the road' protocol designed to be mild for the sicker CFS patients, like myself and my daughter. Some CFS patients get serious flare-ups from large doses of Zinc, so I think that limiting to one moderate dose weekly is wise in this population. Anyway, that is my thinking about zinc... best wishes...

Hi Anon,Good questions. For your first question, neuropathy hiding B12 deficiency symptoms was an unexpected discovery. As soon as I started taking the first four supplements, my nerve function improved. I could tell because sensations all over my body became stronger. Then I began to notice some new symptoms of B12 deficiency, such as raw tongue, different muscle pains, etc. This was added to the more familiar B12 deficiency symptoms. So it seemed to me that the neuropathy was hiding SOME of the symptoms of B12 depletion.

The Solgar brand seems to work better, I don't know exactly why, but the formula is patented by Merck, so there might be published patent info on their process. Another brand I tried was far too strong for me. With my CFS, more moderate approaches tend to work out better in the long run so I have stayed with Solgar.

KurtDid you do a lot of bug killing prior to going on this b12 protocol?I have been doing some version of your protocol for 4 years now, but am still a long way from being able to work part-time.Thank you

Anon,Yes, I spent over a year taking Chlorine Dioxide (MMS) in various doses, before trying this B12 approach. Read my previous blog post on MMS. Also, I eliminated mold, which I react to (that involved relocation), and had worked on diet and some other issues first. Most of this is detailed in prior posts. There might be some prerequisites for some people before the B12 works well. Right now I am adding MMS back to my protocol, but at lower and more frequent doses, and that is having a positive effect, along with the B12.Best wishes

Glad to see you are doing well Kurt. I've been thinking about you lately and then found your blog. My experience of peeling back the layers of symptoms was that the most recent were affected first by the protocol and then the previous layer of symptoms was revealed, and that one healed and the previous layer and so on going though most of them all the way back to where they started. Of course this happens in some months instead of decades in many cases and so much has been forgotten if even noticed in the first place. One of the current discussion is amount of Metafolin. Many of us are finding that larger doses are very helpful, that it aids both active b12s and corrects some long standing problems. For me the two leading edge indicators of folate problems are peeling skin around my nails and angular cheilitis. I'm currently taking 8800mcg/day, very similar to the lower Deplin dose, 7.5mg. I don't know of anybody trying the larger Deplin dose, 15mg. When my skin is healthy around my nails my neurology is also healing. When the skin is worsening and cracks/sores forming at the corners of my mouth my neurology is going downhill. RichVank, in discussion identified the phenomenon sometimes labeled "glutathione detox reaction" and sometimes "NAC detox reaction" as the "methyl-trap" which can be found in 4 decades of peer reviewed literature. It is a situation in which methylfolate is forced out of cells inducing acute methylfolate deficiency.

It took me close to a year to heal enough to be able to do serious rehabilitation which I have done the past 7 years. When all the major factors are in place a lot of healing can happen very quickly. That is when potassium can drop dangerously. Good luck and keep on finding the things that make a difference.

Hi Anon,The neuropathy I experienced was from CFS/Lyme, that was revealed by taking B12, I did not even know I had neuropathy until the nerves started to work again on B12. So I don't think the B6 was involved. There was only a positive, calming response to B6. I did get a bit of a niacin rush though the first few times I took the B multi, that was interesting. But harmless.

Hi Kurt,I've been on an active B12 protocole for two month only, and already have seen some positive change in my CFS induced neuropathy. The problem is that I've had recently a very bad allergy in throat, which seems to be linked to the irritation from the sublingual mB12 and adB12 (you know, "a la Freddd", I let it disolve 2 hours under upper lips). Consequently, I had to try an other solution, and made by myself a B12 cream that I apply transdermally. Have you heard or experienced any positive results with "home-made" transdermal B12 cream? Is it efficient?Thanks a lot for your answer and I apologize for my poor english...Hanna

Hi Hanna,Your English is good! I have not used transdermal B12, but I have used injections before and find the Jarrow mB12 almost as good. But there is a B12 patch on the market, I may try that someday. So are you using a carrier, like DMSO, to get the B12 into the blood? Or just B12 in a creme?--Kurt

I don't use any DMSO or anything else, just let the B12 disolve into a good quality water based body cream. I read on Dr Myhill's site that some of her patients used to make their own magnesium cream with success, so I decided to try it with B12... But it would be great to know if it is as efficient as the sublingual or if I have to adjust dosage.Any additionnal info is welcome! Thanks a lot Kurt.Hanna

Hi AnonI generally take 1 tablet of the Alta Magnesium Chloride mentioned in the post with the B6, once daily (mornings usually). A partial mag tablet seems to work alright at times (usually when I am running out and want to extend). Yes, I have serious sulfation problems, based on a provoked liver detox profile. I had not thought about that connection, don't know if the sulfation is what is being helped, or something else in the methylation. But there is a significant effect to this combination, more energy, calmer nerves, no more chronic fight-flight response, etc.

Anon,I have wondered about that as this seems to work best with mag.chloride. It might just be that the chloride form is well absorbed, and the magnesium can get to the methylation process. But the chloride ions might also support HCl production, improving digestion.

Anon,I took mB12 with magnesium chloride, Ester-C and B6 for a few months before adding the other supplements. Right now I plan to lower the B12 dosages to the lowest level that helps. My B12 blood levels are very high right now (just had that measured). I don't believe that is a problem but probably the excess is not doing much good and it is definitely getting into the bloodstream. Sublingual works.

Thank you for your reply. Did you start all four suppliments at once, or did you start the methil b12 to see how it affected you, and then add the others one at a time? I was told to start one at a time so I'd be able to tell if something is casuing a problem.

Anon,One at a time, starting with a very low dose of mB12 for the first few days. I had taken the ester-c and mag chloride before so knew I could tolerate them. Was not sure about the B6 so waited a few days but it worked out fine. Only with all four did I get the full effect. Some people do not take B6 as well, everyone is unique so I think it is important to try out supplements separately even when you are taking them for their combined effect.

Thanks for putting up all that information and your thoughts, very helpful.

However, I've been on this rollercoaster so many times and I've come to the conclusion that supplements are a futile attempt to coverup a disorder's real cause. You are taking synthetic supplements that are producing a temporary "hit" on your system and making you feel well for a short time, but healing nothing. Your body becomes used to these synthetics and can't product it's own nutrients. It becomes confused...

...You eventually become reliant on these laboratory supplements without natural co-factors and don't fix the underlying problem, making it actually worse. You then take different supplements to fix the damage and you may feel a little better...and on it goes until you get tired of the whole thing.

Example,synthetic B6 can cause various problems, Olive Lead extract can actually lead to B12 deficiency due to strong nature of that supplement acting within the stomach.

Some tips for everyone:

1) for B6 take some Pistachio nuts and bananas.

2) for Magnesium/Zinc take sunflower seeds and pumpkin seeds.

3) Molasses for various minerals.

4) Iodine deficiency, so many choices to top this up, check your thyroid as may be related to low energy.

Yes, you may say the natural doses are not as high as what you get with bottles supps, however they are much more bioactive and have cofactors, so don't need huge doses.

Why are we relying on supplements produced by Solgar (Wyeth) and Merck? These are made in drug laboratories like all their other drugs.

Hi Simon,That might be true if you are taking a 'biologic' substance like cortisol, or an SSRI. But I fail to see how the body will get used to B12 and the related supplements when it is deficient to begin with. This detox and methylation system is not what I would consider to be a 'conditioned' response, it is a system of chemical reactions that respond to the level of oxidative stress in a body, and the presence of toxic substances. When that system is blocked for whatever reason, these 'work around' supplements help keep things running, allowing the body to detox the poisons. Once the detox has been working for awhile, the need for these supplements should reduce. I have been able to reduce some of the doses over the past year (I've been on this protocol now for about 18 months).

However, I do agree with your rollercoaster analogy, and yes, this type of approach is a band-aid until the real causes can be found. But if you don't use band-aids, the wound will fester and you can have worse problems. Anyway, I learned about the stages of treatment through a deliberate trial and error process, trying to do everything at once would be too much, I think best is to add one supplement at a time, take your time working through this detox support, find out what works for you. Someday maybe we will know the cause and can have better treatments.

Hi KurtI think what you are doing is commendable, helping people like me that have been branded and neatly boxed with the tag CFS by the main stream health authorities because they don’t know what to do with us and have no helpful advise. At the very least you are presenting some hope that buts a choice back into our hands.

I will shortly be starting your B12 protocol, do you have any updated or amendments to it that I should include?

Hi Matt,The only thing I have added to the B12 protocol is the use of a rehydration formula. I plan to post on that eventually, the rehydration drink is rice-based and it is really helping. Staying properly hydrated is not as easy as it sounds I am finding. Just drinking liquids does not work, some salt is needed along with a glucose source to bind the sodium and get that to the gut. Details to come, but may take awhile, you are welcome to email me if you are curious or want to try rice-based rehydration, not ready to post that yet but will share with individuals.

Hi Matt,Yes, I'm still around and a little improved, there will be updates posted here eventually, right now I'm working on a better and more comprehensive way to present what I have learned and what is working for me and others with this protocol and the others I have blogged about.

Sorry to hear life is so rough Matt. I have not ever posted the rehydration protocol on the forum or anywhere due to possible patent application. However I can share information privately if that would help. You can email me (my email is at the end of the 'introduction' post).

Yes, the oral rehydrations protocol, which addresses the 'low blood volume' issue with ME/CFS and related conditions. And I am still using methylation support, those are four of the five critical supplements, you left out methylfolate (I use metafolin). Also, have continued using MMS/CDS and that always helps (see my blog post on that topic).