In Killer Freaks from Space, a gory shooter from Ubisoft, one player uses a normal controller to explore a battlefield and kill off mutants. Another player, grasping a Wii U controller, gets a top-down view of the action on his pad, and can use the touchscreen to place enemies and mess with the gun-toting Player 1.
Like a vindictive version of Plants vs Zombies, the RED System, (which stands for Real-time Enemy Director, don'tcha know) lets the player with a Wii U controller drop in swarms of alien bugs and spawn big bad guys.
It ends up as a totally asymmetrical face-off, with one player embroiled in a first person shooter, and the other thinking tactically like he's commanding a strategy game. This could redefine living room mulitplayer.