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There are many ways you could do this. In the report studio design mode, you can select individual column title, go to properties and change the label name. However this is static. If you would like to make it dynamic e.g. based on a prompt selection then you have to use conditional formatting. You could also hide columns based on conditions and render variable settings in the property of each column.

In Query Studio, select the column title you want to change and in the left menu choose the 'Edit Data' category. Then click 'Rename column heading'.
I don't understand hiding columns in Q.S. - what's the purpose of that? If you filter on a column then delete it, that acts like hiding it because it 'remembers' the filter. Maybe that's what you want.

To edit the column heading go to Menu which will be there in the left side
of the query studio window click edit data>rename column heading

To hide the columns what is the reason you need to hide the column in query
studio if it is for filter purpose you can use a column in filter without
having them in the list report you can do that by first adding the column to
your list then apply the filter and then delete the column while deleting it
uncheck the option for the filter deletion.

If this is for any other calculation purpose then i will advice you to use
report studio report to show/hide the column as we don't have this option in
query studio.

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