I try below code and after I quit the application I don't see data at the setting ?

Private Sub Form_FormClosed(ByVal sender As Object, ByVal e As System.Windows.Forms.FormClosedEventArgs) Handles Me.FormClosed
If My.Settings.ColumnOrders1 Is Nothing Then
My.Settings.ColumnOrders1 = New System.Collections.Specialized.StringCollection
My.Settings.ColumnWidth1 = New System.Collections.Specialized.StringCollection
End If

My.Settings.ColumnOrders1.Clear()
My.Settings.ColumnWidth1.Clear()

For Each dc As DataGridViewColumn In dgvData.Columns
My.Settings.ColumnOrders1.Add(dc.DisplayIndex.ToString())
My.Settings.ColumnWidth1.Add(dc.Width.ToString())
Next

1. What is the best media to save (xml, config file) to save layout when its size could become huge, since it allow user to change it independenttly, every user has their own style of grid. Should separate file for each form or grid.

- Config files are xml files so its same thing.
Could we create more than one config files ?
Using xml we can create as many as we wish based on the form name.

- If its just the width and order of columns then you can just store a string like
Since user could change the style : header columns height, columns width, columns shown, columns order, datetime format, number format.

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