Lawson is out due to a hamstring injury, while Johnson will not play after hurting his shoulder in a 47-3 season-opening loss at Baltimore last weekend.

Lawson’s injury further depletes Buffalo’s ability to generate pass pressure. Projected starter Trent Murphy is still catching up after missing a majority of training camp with a groin injury.

Johnson was the Bills’ third cornerback against Baltimore. His injury should lead to veteran offseason free-agent addition Vontae Davis playing against the Chargers after being a healthy scratch last weekend.

Rookie receiver Ray-Ray McCloud is listed as questionable after missing last week with a left knee injury.