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Nasir al-Din Tusi was born in the city of Tus in medieval Khorasan (in north-eastern Iran) in the year 1201 and began his studies at an early age. In Hamadan and Tus he studied the Qur'an, Hadith, Shi'a jurisprudence, logic, philosophy, mathematics, medicine and astronomy.[8]

He was apparently born into a Shī‘ah family and lost his father at a young age. Fulfilling the wish of his father, the young Muhammad took learning and scholarship very seriously and travelled far and wide to attend the lectures of renowned scholars and acquire the knowledge, an exercise highly encouraged in his Islamic faith. At a young age he moved to Nishapur to study philosophy under Farid al-Din Damad and mathematics under Muhammad Hasib.[9] He met also Farid al-Din 'Attar, the legendary Sufi master who was later killed by Mongol invaders, and he attended the lectures of Qutb al-Din al-Misri.

In Mosul he studied mathematics and astronomy with Kamal al-Din Yunus (d. 639/1242). Later on he corresponded with Sadr al-Din al-Qunawi, the son-in-law of Ibn al-'Arabi, and it seems that mysticism, as propagated by Sufi masters of his time, was not appealing to his mind and once the occasion was suitable, he composed his own manual of philosophical Sufism in the form of a small booklet entitled Awsaf al-Ashraf "The Attributes of the Illustrious".

As the armies of Genghis Khan swept his homeland, he was employed by the Ismailis and made his most important contributions in science during this time when he was moving from one stronghold to another.[10] He was captured after the invasion of the Alamut castle by the Mongol forces.[11]

During his stay in Nishapur, Tusi established a reputation as an exceptional scholar. "Tusi’s prose writing, which number over 150 works, represent one of the largest collections by a single Islamic author. Writing in both Arabic and Persian, Nasir al-Din Tusi dealt with both religious ("Islamic") topics and non-religious or secular subjects ("the ancient sciences").[12] His works include the definitive Arabic versions of the works of Euclid, Archimedes, Ptolemy, Autolycus, and Theodosius of Bithynia.[12]

Based on the observations in this for the time being most advanced observatory, Tusi made very accurate tables of planetary movements as depicted in his book Zij-i ilkhani (Ilkhanic Tables). This book contains astronomical tables for calculating the positions of the planets and the names of the stars. His model for the planetary system is believed to be the most advanced of his time, and was used extensively until the development of the heliocentric model in the time of Nicolaus Copernicus. Between Ptolemy and Copernicus, he is considered by many[who?] to be one of the most eminent astronomers of his time.

Ṭūsī criticized Ptolemy's use of observational evidence to show that the Earth was at rest, noting that such proofs were not decisive. Although it doesn't mean that he was a supporter of mobility of the earth, as he and his 16th-century commentator al-Bīrjandī, maintained that the earth's immobility could be demonstrated, but only by physical principles found in natural philosophy.[18] Tusi's criticisms of Ptolemy were similar to the arguments later used by Copernicus in 1543 to defend the Earth's rotation.[19]

About the real essence of the Milky Way, Ṭūsī in his Tadhkira writes: "The Milky Way, i.e. the galaxy, is made up of a very large number of small, tightly-clustered stars, which, on account of their concentration and smallness, seem to be cloudy patches. because of this, it was likend to milk in color." [20] Three centuries later the proof of the Milky Way consisting of many stars came in 1610 when Galileo Galilei used a telescope to study the Milky Way and discovered that it is really composed of a huge number of faint stars.[21]

In his Akhlaq-i-Nasri, Tusi put forward a basic theory for the evolution of species almost 600 years before Charles Darwin, the English naturalist credited with advancing the idea, was born. He begins his theory of evolution with the universe once consisting of equal and similar elements. According to Tusi, internal contradictions began appearing, and as a result, some substances began developing faster and differently from other substances. He then explains how the elements evolved into minerals, then plants, then animals, and then humans. Tusi then goes on to explain how hereditary variability was an important factor for biological evolution of living things:[22]

"The organisms that can gain the new features faster are more variable. As a result, they gain advantages over other creatures. [...] The bodies are changing as a result of the internal and external interactions."

Tusi discusses how organisms are able to adapt to their environments:[22]

"Look at the world of animals and birds. They have all that is necessary for defense, protection and daily life, including strengths, courage and appropriate tools [organs] [...] Some of these organs are real weapons, [...] For example, horns-spear, teeth and claws-knife and needle, feet and hoofs-cudgel. The thorns and needles of some animals are similar to arrows. [...] Animals that have no other means of defense (as the gazelle and fox) protect themselves with the help of flight and cunning. [...] Some of them, for example, bees, ants and some bird species, have united in communities in order to protect themselves and help each other."

Tusi recognized three types of living things: plants, animals, and humans. He wrote:[22]

"Animals are higher than plants, because they are able to move consciously, go after food, find and eat useful things. [...] There are many differences between the animal and plant species, [...] First of all, the animal kingdom is more complicated. Besides, reason is the most beneficial feature of animals. Owing to reason, they can learn new things and adopt new, non-inherent abilities. For example, the trained horse or hunting falcon is at a higher point of development in the animal world. The first steps of human perfection begin from here."

"Such humans [probably anthropoid apes] live in the Western Sudan and other distant corners of the world. They are close to animals by their habits, deeds and behavior. [...] The human has features that distinguish him from other creatures, but he has other features that unite him with the animal world, vegetable kingdom or even with the inanimate bodies. [...] Before [the creation of humans], all differences between organisms were of the natural origin. The next step will be associated with spiritual perfection, will, observation and knowledge. [...] All these facts prove that the human being is placed on the middle step of the evolutionary stairway. According to his inherent nature, the human is related to the lower beings, and only with the help of his will can he reach the higher development level."

"What spurred him to this was that in the assertoricsyllogisticAristotle and others sometimes used contradictories of absolute propositions on the assumption that they are absolute; and that was why so many decided that absolutes did contradict absolutes. When Avicenna had shown this to be wrong, he wanted to give a way of construing those examples from Aristotle."[23]

Al-Tusi was the first to write a work on trigonometry independently of astronomy.[24] Al-Tusi, in his Treatise on the Quadrilateral, gave an extensive exposition of spherical trigonometry, distinct from astronomy.[25] It was in the works of Al-Tusi that trigonometry achieved the status of an independent branch of pure mathematics distinct from astronomy, to which it had been linked for so long.[26][27]

He was the first to list the six distinct cases of a right triangle in spherical trigonometry.

^a) "Tusi, Nasir al-Din. " Encyclopædia Britannica. 2007. Encyclopædia Britannica Online. 27 December 2007 <http://www.britannica.com/biography/Nasir-al-Din-al-Tusi>. b)Arthur Goldschmidt, Lawrence Davidson. "A Concise History of the Middle East", Westview Press, 2009. ninth edition, pg 127: "Hulegu, contrite at the damage he had wrought, patronized the great Persian scholar, Nasiruddin Tusi (died 1274), who saved the lives of many other scientists and artists, accumulated a library of 400000 volumes, and built an astronomical ..."; [1] d) Nanne Pieter George Joosse, Bar Hebraeus, "A Syriac encyclopaedia of Aristotelian philosophy: Barhebraeus (13th c.), Butyrum sapientiae, books of ethics, economy, and politics: a critical edition, with introduction, translation, commentary, and glossaries", Published by Brill, 2004. excerpt: " the famous Persian scholar Naslr al-Dln Tusi "; e)Seyyed Hossein Nasr," Title Islamic philosophy from its origin to the present: philosophy in the land of prophecy", Publisher SUNY Press, 2006. pp 167: "In fact it was common among Persian Islamic philosophers to write few quatrains on the side often in the spirit of some of the poems of Khayyam singing about the impermanence of the world and its transience and similar themes. One needs to only recall the names of Ibn Sina, Suhrawardi, Nasir al-Din Tusi and Mulla Sadra, who wrote poems alongs with extensive prose works"

^Rodney Collomb, "The rise and fall of the Arab Empire and the founding of Western pre-eminence", Published by Spellmount, 2006. pg 127: "..Khawaja Nasr ed-Din Tusi, the Persian, Khorasani, former chief scholar and scientist of ";

^Seyyed Hossein Nasr. The Islamic Intellectual Tradition in Persia. Curson Press, 1996. See p. 208: "Nearly 150 treatises and letters by Nasir al-Din Tusi are known, of which 25 are in Persian and the rest in Arabic. There is even a treatise on geomancy which Tusi wrote in Arabic, Persian, and Turkish, demonstrating his mastery of all three languages."

^Also the 'sine law' (of geometry and trigonometry, applicable to spherical trigonometry) is attributed, among others, to Alkhujandi. (The three others are Abul Wafa Bozjani, Nasiruddin Tusi and Abu Nasr Mansur). Razvi, Syed Abbas Hasan (1991) A history of science, technology, and culture in Central Asia, Volume 1 University of Peshawar, Peshawar, Pakistan, page 358, OCLC26317600

^Bijli suggests that three mathematicians are in contention for the honor, Alkhujandi, Abdul-Wafa and Mansur, leaving out Nasiruddin Tusi. Bijli, Shah Muhammad and Delli, Idarah-i Adabiyāt-i (2004) Early Muslims and their contribution to science: ninth to fourteenth century Idarah-i Adabiyat-i Delli, Delhi, India, page 44, OCLC66527483