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This AU portrays as the four as a group of meta-humans (normal human beings embedded with extraordinary powers) that team up in a world of superheroes and super villains. As the name implies, this AU most commonly places them in the Marvel Cinematic Universe, though this is not required.

The world of Marvel has been a popular universe for fans to use for crossovers, considering the lack of restrictions the universe has on magic and powers. The Avengers Initiative is a prime place for the Big Four to appear in the universe because of a number of reasons: it has a focus of combining many powers for one ultimate goal, it allows for the use of magic and the idea of dragons, and it adds action and adventure to really spice up a story. Also, the Marvel comic world is abundant in supernatural and legendary beings and creatures, allowing with vampires and monsters, gods, and even cavemen and alien races.

Jack Frost, because his legend originates from Norse Mythology (Jokul Frosti), is often seen as an Asgardian in the same manner as Thor, or maybe his foes the Frost Giants. Another common interpretation places him in the role of Tony Stark (AKA Iron Man) for his carefree attitude, power of flight and mischeivous streak. In more common instances, Jack is sometimes portrayed as the Son of Loki and brother to Elsa. In the crossover for the TV show Agents of S.H.I.E.L.D, he is portrayed as Agent Ward. Jack is also portrayed as Quicksilver (when Merida or his little sister is the Scarlet Witch), Deadpool, Star-Lord (when the Guardians are the other members of the Guardians of the Galaxy), Spider-Man, Mr. Fantastic and The Human Torch. Jack is also cast as Captain America - as they were both given new lives when they were "brought" out of ice - when Hiccup is the Bucky Barnes A.K.A. the Winter Soldier (or vice versa).

Rapunzel is seen mostly as Captain America for her bravery and her goodness. In Agents of S.H.I.E.L.D, she is Jemma Simmons, due to her excitable and smart personality. Fans have also cast her as the Scarlet Witch, Spider-Gwen (or on rare occasions Gwenpool) and The Invisible Woman.

Merida seems to serve as Hawkeye in this AU, because of her skills of archery. A common interpretation portrays Merida as Hawkeye and Black Widow's daughter, possessing her father's skills in archery and her mother's red hair. Fans have also cast her as Black Widow (herself) and the Scarlet Witch. In Agents of S.H.I.E.L.D, she is portrayed as Skye due to similar personalities.

Much like Jack, Hiccup's identity in the AU is interchangeable between an Asgardian like Thor (due to his Viking heritage) or Iron Man (for his intellect and skills at crafting). Some fan art has also portrayed Hiccup as Bruce Banner (both are intelligent) and Toothless as The Hulk. In the TV show Agents of S.H.I.E.L.D, he is portrayed as Leo Fitz, due to their high intelligence and engineering skills. He is also portrayed as Hawkeye, Mr. Fantastic or The Human Torch from The Fantastic Four and the web swinging, spider-like superhero, Spider-Man. Hiccup is also cast as Captain America - as they had people looking down them and having shields as one of their weapons - when Jack is the Bucky Barnes A.K.A. the Winter Soldier (or vice versa). Since Hiccup's Flightsuit looks a bit similar to the Ant-Man suit, he can be portrayed as the shrinking and growing former thief, Ant-Man, with ant like and size dragons as Hank Pym's ant army. While being the current leader of his tribe, had lost his father, is sometimes given a dark suit in superhero related AUs and Toothless being placed as a black cat for modern related crossovers and AUs, could even place Hiccup as Black Panther.

Ever since the creation of the fan-made internet-video How Frozen Should Have Ended, many fans like to believe Elsa to be a mutant. Much like the mutants of the Marvel Universe, Elsa holds a deep fear of prejudice for having powers she was born with, and has much difficulty controlling these powers to the degree that it could hurt innocent bystanders. In context with The Avengers, many people compare Elsa to the Scarlet Witch, Black Widow and the Winter Soldier, when Anna is Captain America. In more common instances, Elsa is sometimes portrayed as the Daughter of Loki and sister to Jack. Fans have also placed her as Gamora, Spider-Man/Woman or Spider-Gwen.

Occasionally, Hiro and Baymax are inserted into the story in the place of Iron Man. Baymax is like the suit itself, being able to fly and being a robot, whereas Hiro is like Tony Stark, being the genius inventor that thinks of all kinds of cool gadgets to upgrade Baymax. Hiro has also been placed as Mr. Fantastic, while Baymax is portrayed as an armored version of Thing.

Since the team are based on the Marvel comic Big Hero 6 team, they can be portrayed as the characters that they are based on, along with having their abilities. They can also be cast as members of the Avengers, and other Marvel heroes and characters; along with being Mutants from the X-Men universe.

Ralph is known for his huge size, anger issues, and destructive power that leaves him ashamed of himself. This, coupled with everyone's view of him as a monster and attempted learning to control his power, would make it easy for writers to cast him as The Hulk or Drax.

Violet's invisibility and force field powers and being a older sibling heavily resembles and casts her as the Invisible Woman from The Fantastic Four. She is also seen as the Scarlet Witch, for having a brother with super speed powers or portrayed as Gwen Stacy (which could also make her Spider-Gwen) for the Hiret pairing when Hiro is the Amazing Spider-Man.

They can even be placed as Mutants, Inhumans or any other kind of superpowred race and even specie. As the Guardians are supernatural and mystical beings, as well as MiM and Bunny's kind originating from another planet and system before ending up on earth.

Nod's small size, being able to jump to high places, riding a small, winged steed and being well acquainted with a professor and his daughter, easily casts him as Ant-Man. In which the Katherinod can portray M.K. as the Wasp.

Since Drac is vampire that is based on a character (that shares the same name as the main character) from Bram Stoker's novel, he can easily serve as Marvel's antagonist version of Dracula. As well as any other vampire from the Marvel universe, along with Mavis, their family and other vampires from the world of Hotel Transylvania.