Dr. Huai (Howard) Deng

Professional title

Bio

My laboratory is generally interested in the molecular mechanisms that mediate developmental adaptations to environmental changes. In particular, my research focuses on the Keap1-Nrf2 oxidative/xenobiotic response pathway in Drosophila model system. We are exploring the novel functions of these factors in 1) selective transcriptional responses to different signals, 2) chromatin structure remodeling, and 3) regulation of developmental programs, using a combination of imaging, genetic, and molecular approaches. In addition, my laboratory is interested in developing fluorescence imaging tools to directly visualize protein complexes on chromatin, and using this approach to study combinatory interactions among transcription factors and chromatin modifiers.