This thesis consists of two parts. The first part is a systematic review evaluating the available evidence for the use of mindfulness-based interventions (MBIs) in people with neurodegenerative disorders (NDDs). 12 studies met inclusion criteria and involved people with three disorders, Multiple Sclerosis, Parkinson’s Disease and Dementia/Mild Cognitive Impairment. There is promising evidence that MBIs benefit people with a NDD, particularly those with MS in reducing symptoms of anxiety and depression. More high quality studies employing robust methodology such as RCTs with adequate statistical power are needed in PD and dementia/MCI. The second part is an empirical paper focusing on how individuals with acquired brain injury make sense of their experiences of learning and practicing mindfulness skills. Fifteen participants attending a mindfulness group at the local brain injury rehabilitation centre were recruited to two data collection methods. Focus group interviews were analysed using Interpretative Phenomenological Analysis and in-vivo recordings were analysed using Template analysis. Results suggested that most participants considered mindfulness beneficial to cope with emotional and cognitive consequences of ABI. The ‘live’ nature of in-vivo recordings revealed rich descriptions about their individual mindfulness practice. The limitations of this study, future research and clinical implications have been discussed.