I like to recommend you HOULIHAN'S on 111 E Wacker Dr for American Seafood. The location is great, food is delicious and the service is top notch. You can also make use of this search engine http://www.boorah.com/restaurants/ to find restaurants specializing in Sea food & for reviews

Agree with Chicgail. Houlihans is below average chain. I had no idea that there was even one in the loop. Please do not waste your money on it. I have had some good fish preps at steakhouses. Keefers had some tasty choices. You may want to think in that direction.

There are three excellent restaurants specializing in seafood, all within a block of the Chicago River just north of the Loop, about a 10-15 minute walk from the Palmer House. One is the previously-mentioned Catch 35, on Wacker on the south bank of the river. Just across the river are Shaw's Crab House ( www.shawscrabhouse.com ) and Fulton's on the River ( www.levyrestaurants.com ).

Catch 35 is wonderful. And, the last time I was there they had a very good pianist playing during the Happy Hour. Nicks used to be good - at least the one by O'hare but has gone down big time over the years - and is expensive! Houlihans? Why? You can get a fish sandwich at McD's and not even get out of your car!

Within a recent two week period both my wife and I individually visited Chicago for work. We both happened to stayed at the Marriott Renaissance on Wacker. My wife had dinner at Catch 35; I found my way to McCormick and Schmicks. Each is about a half block from the hotel.

My dinner at McCormick and Schmick was disappointing and the service was wanting. I ordered Mahi-Mahi and it was served overcooked with an overly salty sauce. For the price I paid I left very disappointed. My wife on the other hand raved about her meal at Catch 35. Good luck.