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We have identified MHC class II molecules as a molecule that transports cellular misfolded MHC class I molecules to the cell surface. When we analyzed other proteins, hen egg lysozeme, immunoglobulin heavy chain and β2-glycoprotein I were also transported to the cell surface by MHC class II molecules upon association with MHC class II molecules. Furthermore, these misfolded proteins transported to the cell surface by MHC class II molecules were found to be specific targets for autoantibodies produced in rheumatoid arthritis and antiphospholipid syndrome. In order to identify molecules that transport misfolded proteins to the cell surface, we analyzed molecules that associate with misfolded proteins at the cell surface. We found that several molecules are associated with misfolded proteins by mass spectrometry.