Drug Interactions With Protriptyline

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Combining protriptyline with phenothiazine medications can increase the level of protriptyline in your blood, increasing your risk of side effects. Also, combining protriptyline with certain phenothiazines can increase your risk of a dangerous irregular heart rhythm called QT prolongation. Talk to your healthcare provider before taking these medications together.

Pressors

If protriptyline is taken with pressor medications, it can increase your risk of side effects. Your healthcare provider may need to adjust your dose of these medications to prevent this interaction from occurring.

SSRI or SNRI Medications

Taking protriptyline with SSRIs or SNRIs can increase the level of protriptyline in your blood, increasing your chance of side effects. Your healthcare provider may need to adjust your dose of these medications or use caution when switching from one medicine to another.

Thyroid Medications

Taking protriptyline with thyroid medications can increase your risk of protriptyline side effects. Your healthcare provider may need to adjust your dose of these medications as a result.

Tramadol

Combining tramadol and protriptyline can increase your risk of seizures. Talk to your healthcare provider before taking these medications together.

Tricyclic Antidepressants

Taking protriptyline with other tricyclic antidepressants can increase your risk of side effects. Your healthcare provider may need to adjust your dose of these medications to keep this interaction from occurring.

Final Thoughts on Drug Interactions With Protriptyline

It is possible that not all drug interactions with protriptyline were discussed in this article. Therefore, you should talk with your pharmacist or healthcare provider about the specific interactions that may apply to you.

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