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(Reuters) - Insys Therapeutics Inc's legal woes deepened on Thursday as New York's attorney general filed a lawsuit seeking at least $75 million from the company, which he said deceptively promoted a fentanyl-based cancer pain medicine for unsafe uses.

The US state of Texas put to death Thursday a man who executed his two young daughters while forcing his ex-wife to listen on the phone. John Battaglia shot to death his six- and nine-year-old daughters in 2001, when they were visiting him for dinner. Battaglia's lawyers filed last-minute appeals claiming he suffered from mental illness and delusions that made him incapable of understanding why he was being punished.

A man who killed his two young daughters at his Dallas apartment in 2001 while the girls' mother listened on the phone and heard the fatal gunshots and her children's screams, was executed in Texas on Thursday, prisons officials said. John Battaglia, 62, a former accountant was put to death by lethal injection at the state's death chamber in Huntsville after the execution was delayed for several hours for federal courts to consider last-minutes appeals to spare his life. Lawyers for Battaglia argued he suffered from severe mental illness and was incompetent to be executed.

NEW YORK (Reuters) - Array BioPharma Inc on Thursday sued AstraZeneca AB, accusing the pharmaceutical company of refusing to pay required royalties for a cancer drug after entering into an $8.5 billion collaboration with Merck & Co.

Record profits for Amazon added billions to CEO Jeff Bezos’ world-leading worth. Already ranked as the world’s richest man, surpassing Microsoft founder Bill Gates as his net worth surged to an estimated $105bn (£73bn) earlier this month, Mr Bezos saw his fortune increase further as Amazon reported its largest-ever profits. The Seattle-based company posted revenue of $60.5bn (£42.4bn) and earnings of $3.75 (£2.6) per share, helping it to eclipse estimates for its fourth quarter figures.

The Afrin offensive marks a major new phase of the Syrian conflict, likely bookending the conflict with ISIS and the civil war. Turkey’s decision to launch an operation in Afrin in northern Syria has opened a new front and phase in the Syrian conflict. Ankara says its offensive alongside Syrian rebel allies is aimed at eliminating the Kurdish People’s Protection Units (YPG) control of the mountainous area around the city of Afrin that has been a mostly Kurdish-controlled enclave for five years.

It is time for the world to accept that “peace on the Korean Peninsula” begins when the Kim regime ends. As the two Koreas march together under a “unification flag” at the 2018 Winter Olympics in PyeongChang next month, life in North Korea will go on as usual.

Prostate cancer has overtaken breast cancer to become the third deadliest type of the disease in Britain, new research has found. For the first time, figures show that more men are dying from prostate cancer than women from breast cancer, amid warnings from charities and health campaigners that more investment is needed. The research, published today by Prostate Cancer UK, reveals that 11,819 men died of prostate cancer in 2015, the equivalent of one every 45 minutes, compared with 11,442 women who died of breast cancer. To halt the rise, the charity estimates that more than £120m in research funding is needed to make sufficient advances in research, screening and treatment. Although the mortality rate for breast cancer has continued to fall steadily since the Nineties, the number of men dying from prostate cancer has risen by more than 20 per cent during the same period. Lung cancer and bowel cancer remain the deadliest cancers in the UK, with more than 50,000 people dying of the diseases annually. Prostate and Breast cancer deaths in UK Whilst welcoming advances in breast cancer treatment, Prostate Cancer UK said that levels of funding for prostate cancer had been significantly lower, meaning efforts to tackle the disease are trailing behind. Since 2002, more than £520m has been invested in tackling breast cancer, more than double the amount received for prostate treatment and research. Scientific research into the disease has also been lower historically, with just 72,513 papers on prostate cancer published since 1999, compared with more than 146,000 on breast cancer. “With half the investment and half the research it’s not surprising that progress in prostate cancer is lagging behind,” said Angela Culhane, the charity’s chief executive. “However, the good news is that many of these developments could be applied to prostate cancer and we’re confident that with the right funding, we can dramatically reduce deaths within the next decade. “The wheels are already in motion to turn these statistics around. Plans to create an accurate test fit for use as part of a nationwide prostate cancer screening programme, as well as developing new treatments for advanced prostate cancer are already well underway. “However, to achieve these aims we need to increase our investment in research. We’re calling on the nation to sign up to a March for Men this summer to help raise the funds we desperately need to stop prostate cancer being a killer.” The facts | Prostate cancer Due to an ageing population, the number of men dying from prostate cancer has continued to rise despite survival rates being 2.5 times higher than they were 30 years ago. In a bid to reverse the trend, Prostate Cancer UK has recently invested £2m into developing tests which it hopes will eventually be adopted into a national screening programme. Currently, the NHS does not have a national screening for PSA testing, but men aged 50 or over can have tests if they ask for them. More than £1.4m has also been invested into developing tailored treatments for men at advanced stages of the disease, which it hopes will extend the lives of 9,000 patients annually. Prostate cancer is the most common form of cancer for men in the UK, with 47,000 diagnoses annually.

CROZET, Va. (AP) — The safety arms at a railroad crossing where a train carrying Republican lawmakers slammed into a garbage truck appeared to be malfunctioning the day before the deadly crash, drivers who regularly cross over the tracks at the crash scene said Thursday.

NEW YORK (Reuters) - The U.S. government on Thursday proposed an increase of 1.84 percent on average in its 2019 payments to the health insurers that manage Medicare Advantage insurance plans for more than 20 million elderly or disabled people.

WASHINGTON (AP) — Afghan forces backed by U.S. troops in Afghanistan's turbulent Helmand Province have gained ground in recent months, but the Taliban still maintains control over roughly half the province, according to the senior Marine commander who just returned from a nine-month deployment to the region.

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