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These have all been created by a variety of well-known constructors. There may be one or two that we might question, but they're still fun. Please explain all answers.

-1. Call sheet (4)-2. I represent new business venture (10)-3. Pyrex pan set included with range (7)-4. Back ends of Brazilian city covered with placards (10)-5. Struggle with gutless gardener over fruit (7)-6. Counting on relieving pain outside of emergency room (9)-7. Louisiana, to bigwig from the South, is crucial (7)-8. Bill's fashionable opinion (7)-9. Fish head removed from fishing equipment (4)-10. An irritating guy's place in Belgium (7)

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You matter. Until you multiply yourself by the speed of light squared. Then you energy.