Summariesfor ACSL3 gene

The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although

differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this

family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid

biosynthesis and fatty acid degradation. This isozyme is highly expressed in brain, and preferentially utilizes

myristate, arachidonate, and eicosapentaenoate as substrates. The amino acid sequence of this isozyme is 92%

identical to that of rat homolog. Two transcript variants encoding the same protein have been found for this

gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for ACSL3 Gene:

ACSL3 (acyl-CoA synthetase long-chain family member 3) is a protein-coding gene. Diseases associated with ACSL3 include saethre-chotzen syndrome. GO annotations related to this gene include protein kinase binding and long-chain fatty acid-CoA ligase activity. An important paralog of this gene is ACSL4.