No, those times aren't normal. And the fact that they're appearing there are proof of it.

Allow me to elaborate:

GetPendingActivities runs (roughly) once every 0.5 seconds*. Over the course of one week that'll be 1209600 times. Of those times, only 415 (0.03% of executions) were over 200ms. The vast majority of the executions were perfectly acceptable, likely immediate.

A similar analysis could be made for most the other queries.

What this data shows is that sometimes these queries get slow... really slow. It would be important to find out where in time these slowdowns occurred, to be able to correlate with other events.

They could be slow during database maintenance tasks, or during unusual peak hours. You can check these timings by going through the General Log (filtering by SLOWSQL).

In conclusion: I wouldn't fret about this.

* this is off the top of my head, I will double check this information. But it gets ran A LOT.