We are interested in understanding how the brain is wired for processing information from the environment to generate approach-avoidance behaviours, with a particular focus on neuronal circuits that modulate behaviours associated with anxiety and schizophrenia. Using the mouse as a model organism, we are currently using various genetic approaches for neuron manipulation, including opto- and pharmacogenetics. We hope that the resultant findings yield new insights into the pathophysiology of schizophrenia and anxiety-related disorders and potentially provide new therapeutic targets for their treatment.