Carac
RX_link

Carac
fda sheet

Carac
msds (material safety sheet)

Carac
Synthesis Reference

Carac
Molecular Weight

130.077 g/mol

Carac
Melting Point

280-282oC

Carac
H2O Solubility

< 0.1 g/100 mL at 19 °C

Carac
State

Solid

Carac
LogP

-0.77

Carac
Dosage Forms

Topical preparations; Solution for injection

Carac
Indication

For the topical treatment of multiple actinic or solar keratoses. In the 5% strength it is also useful in the treatment of superficial basal cell carcinomas when conventional methods are impractical, such as with multiple lesions or difficult treatment sites. Fluorouracil injection is indicated in the palliative management of some types of cancer, including colon, rectum, breast, stomach and pancrease.

Carac
Pharmacology

Fluorouracil is an antineoplastic anti-metabolite. Anti-metabolites masquerade as purine or pyrimidine - which become the building blocks of DNA. They prevent these substances becoming incorporated in to DNA during the "S" phase (of the cell cycle), stopping normal development and division. Fluorouracil blocks an enzyme which converts the cytosine nucleotide into the deoxy derivative. In addition, DNA synthesis is further inhibited because Fluorouracil blocks the incorporation of the thymidine nucleotide into the DNA strand.