Before treatment:
Mr. Wide started to feel numbness in his fingers 12 years ago, he also had thenar and anterior mild muscular atrophy and weakness, so he went to the hospital and had some examinations done. He was diagnosed with CMT, his disease progressed day by day. He felt numbness in his limbs 6 years ago. He couldn’t do fine movements well, he had muscle weakness, he could take care of himself sometimes. He wanted a better life so he came to our hospital.
His spirit, eating and sleeping were good, his urination and bowel movements were normal.

Admission PE:
Bp: 129/84mmHg, Hr: 67/min, breathing rate: 18/min, body temperature: 36.0 degrees. Nutritional status is normal, normal physical development. There are no bleeding spots on his skin or mucosa. There is no cyanosis. There is no throat congestion, and the tonsils are not swollen. The chest development is normal, the respiratory sounds in both lungs are clear. There are no dry or moist rales. The heart beat is powerful with arrhythmia, with no obvious murmur in the valves. The abdomen is flat, with no masses or tenderness. The liver and spleen are normal, shifting dullness test is negative. The spinal column is normal. There is no edema in the lower limbs.

Nervous System Examination:
Mr. Wide is alert and he is in good spirits. His speech is clear. His memory, orientation and calculation ability are normal. Both pupils are equal in size and round, with a diameter of 3mm. Both pupils react well to light, and the eyeballs can move freely. There is no nystagmus. The bilateral forehead wrinkle pattern and nasolabial fold are symmetrical. The tongue is centered in the oral cavity. The teeth are shown without deflection. The cheeks can be expanded strongly and the chewing ability is normal. The soft plate can lift powerfully. The eyes can close normally. The neck muscles are flexible. The head can be moved freely. The shoulders can shrug normally. The muscle strength of the upper limbs is at level 5-, the gripping strength of both hands is at level 4-, the muscle strength of the fingers is at level 3+. The muscle strength of the lower limbs is at level 5-, the planter and dorsal muscle power is at level 4-. The muscle tension is normal. The bilateral forearm muscles, thenar muscles and interosseous muscles in both hands have atrophy: the interosseous muscles in both feet have atrophy. The bilateral upper limb tendon reflexes are not elicited, the bilateral lower limb tendon reflex is reduced. The bilateral Babinski’s sign is positive. The abdominal reflexes are normal. The bilateral palm jaw reflex is negative. The bilateral Hoffmann’s sign is negative. The bilateral Rossolimo’s sign is negative. The bilateral superficial sensation is normal. There is numbness in the distal ends of the fingers on both hands the right lower leg and the left toes. The double lower limbs graphics positioning sensation and joint position sensation are a little bit poor. Both hands can finish the finger to nose test, the fast alternating test and finger to finger test. The bilateral heel-knee-tibia test is normal. The meningeal irritation sign is negative.

Treatment:
After the admission, Mr. Wide was diagnosed with Charcot-Marie-Tooth disease. He received 3 neural stem cell injections and 3 mesenchymal stem cell injections to repair his damaged motor nerves, replace the dead nerves with new injected stem cells, activate the nerves in his body, nourish the nerves, regulate his immune system and improve the blood circulation. This was combined with rehabilitation training.

Post-treatment:
After 14 days of treatment, Mr. Wide felt stronger, he felt less numbness, his gripping strength was at level 5-, the muscle power of the fingers was at level 4-, the planter and dorsal muscle power was at level 4+. He walked better and his stamina and energy were both increased.