Although T has a 50% (!) faster absorption than R, tmax of T is only 15 min earlier than the one of R (reflected both in concentrations and effects). The T/R-ratio of Cmax is 113% but the maximum effect increases by only 1.5%! Is that relevant?
This is a very simple PK/PD-link model. With others (e.g., incorporating a delay in onset) the observed difference in PK may disappear completely in PD. If we have no data about the PK/PD-relationship we are left out in the dark. I’m aware of only a few studies (rapid onset for multiphasic products of zolpidem and methlyphenidate).

—Regards,
Helmut Schütz

The quality of responses received is directly proportional to the quality of the question asked. ☼Science Quotes