Biden announced that he would appear with the new host of the NBC talk show via Twitter: "Must-see TV." The vice president, who has had his share of bloopers over the course of his career, adds a lively political touch to the debut, which will also feature Meyers' former "Saturday Night Live" castmate Amy Poehler.

Perhaps Poehler will appear in Hillary Clinton guise. ("Stop saying I have cankles.")

Must-see TV: The VP will appear on the first episode of Late Night with @sethmeyers on 2/24.

Biden has had previous moments in the late-night limelight. He was a frequent target of Jay Leno, who once quipped: "Vice President Joe Biden is on a trip to Bosnia, Serbia and Kosovo. The White House is calling it 'Operation Keep Biden Away From the Microphones.' "