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It's since been discovered that leptin is part of a complex set
of regulatory mechanisms that govern appetite and obesity. So
researchers think any one drug alone is not going to be sufficient
to regulate weight and appetite.

San Diego-based Amylin Pharmaceuticals says it has made progress
in understanding how the appetite and metabolic mechanisms work
together. Amylin licensed the rights to the leptin drug from Amgen,
and is now testing it in human clinical trials in combination with
pramlintide, a drug it developed on its own.

Pramlintide is derived from amylin, a hormone that acts with
insulin to control blood sugar and weight control. Pramlintide and
leptin given together to rats produce greater weight loss than
would be expected from the combination of their individual effects,
according to a paper by Amylin researchers published in the July 31
issue of the journal Endocrinology.