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The MP5 is a moderately powerful submachine gun available to both teams. Its only major disadvantage is its low damage. It has one of the fastest rate of fires out of the SMGs, second to P90, and is the most accurate SMG along with the UMP45. Just like in real life, its 9mm bullets are stopped rather easily by kevlar. The MP5 is very attractively priced at $1500. For these reasons, the MP5 is very common in early rounds but is usually replaced by a rifle of choice in later rounds. Players on the losing side can afford the MP5 and kevlar to retain a competitive edge. The MP5 is one of the most iconic and most used weapons in Counter-Strike, alongside with the M4A1, AK-47, AWP, and the Desert Eagle.

Aim for the head or the chest and spray bullets at close range. The most it can take to kill is 2 shots to the head of an armored enemy player.

At medium range, aim for the stomach and spray bullets, or burst-fire for the head while crouching. This will hopefully result in a headshot.

Crouch and shoot one shot at a time at long range. However, retreating may be a better idea unless you are up against a pistol (excluding the Desert Eagle and the Five-SeveN) , a shotgun, and another SMG user.

Use the fast rate of fire to your advantage by spraying bullets. Aim at the stomach to ensure all bullets hit a target.

Strafe continuously. An MP5 user is quicker and more accurate while strafing than a rifleman.

Reloading could take some time so make sure you reload regularly. Also, equip a pistol you prefer in case you have no time to reload.

If you do score a headshot but the target is not eliminated, aim the MP5 at the lower sections of the opponent and keep firing or switch to a more powerful pistol, such as the Desert Eagle, to finish him off.

The MP5 is more effective in older Counter-Strike games, however if you can score headshots with the MP5 in Source, you should be fine. MP5 users might find difficulties killing their enemies quickly if they have purchased Kevlar. Scoring headshots are very important to your survival (especially if opponents you face are not hurt yet).

Spraying at exposed legs of targets while crouching with this weapon at mid-close ranges can kill enemies quickly, since Kevlar doesn't provide protection for the legs.

Use other powerful short-range weaponry, like the P90 or a shotgun, or a weapon with a higher rate of fire at close. However, this will be slightly more difficult than the other options, especially if your weapon is a pump shotgun or has higher recoil than the MP5, like the Galil. This can be an issue in older games.

In Source, the Galil and the FAMAS are good means to counter MP5 users at close proximity. The former depends on its superior rate of fire while the latter has the advantage of accuracy.

Other CT bots will buy the MP5 when they cannot afford the P90, any assault rifles, or sniper rifles. If CTs have a weapon preference of using submachine guns and cannot purchase the MP5, they will purchase the TMP instead.

It should be noted unlike the CTs, Terrorists will never buy the MP5 when they cannot afford the P90. Instead, they will buy the cheapest submachine gun, the MAC-10. However, if they cannot afford any sniper rifles or assault rifles, they will buy the MP5 instead.

The player rarely gets the MP5, despite having fairly balanced performance in combat. The MP5 is commonly used by both NPC controlled Counter-Terrorists and Terrorists. The player will get the MP5 in the following missions:

Secret War: As a starting loadout. It is also commonly used by many other Spetsnaz operatives in this mission.

Fastline (mission): Found on a table in one of the noodles shop. It is important to get this weapon as the M3 have pellet spread which can hurt the hostages while attacking the boss and the Five-SeveN is ineffective to deal the boss due to low damage per shot.