National distribution is occurring in support of new brands DB Hobbs Lager and DB Hobbs Light, at 4.81% abv and 4.15% abv respectively, which some publications indicate may be relabeled versions of the LaCrosse Lager line.[4]

As Anheuser-Busch moved production of Rolling Rock to New Jersey in 2006, an owner was sought for the original Latrobe Brewing Company in Pennsylvania. City Brewery completed the purchase and in March 2007, the Latrobe brewery reopened its doors and produced Samuel Adams. The Boston Beer Company signed a deal with the plant's current owners in April 2007, to produce beer in the plant. The Boston Beer Company had pledged 3 to 7 million dollars to upgrade the plant. It is estimated that 200,000 to 250,000 barrels of beer would be produced in the plant during the remainder of 2007.[5]

In late October 2008, City Brewery-Latrobe laid off 70 workers forcing a temporary shutdown, and stopped brewing beer at the plant in November.[6] Boston Beer Co. moved their operations to an old Pabst brewery they purchased near Allentown, PA.[7] In May 2009, Iron City Brewing signed a deal with City Brewing Co to begin producing beer at the plant,[8] with brewing started in June and bottling/kegging production resumed in July, 2009.[9]

In July 2009 some Southampton brands (Double White, IPA, Altbier, Pumpkin, Imperial Porter) were moved to Latrobe from Lion Brewing.

In addition to Iron City Beer, City Brewing also produces Stoney's and Stoney's Light in Latrobe.

On December 8, 2009 City Brewing Latrobe completed the installation of a can line and started canning in 12 and 16 ounce packages. A 24 ounce can line is also now available.