EffectGASDon learning and memory in the dementia rats induced by hippocampal lesions due
to quinolinc acid

By one trial passive avoidance response step-down tast and
water maze spatial local-ization tast, we observed the effect of GASD on pathological models of
the dementia rats induced byhippocampal lesions due to quinolinic acid. The results suggested
that GASD could improve learningand memory deficiency in rats with bilateral hippocampal
lesions after administration of quinolinicacid.The major mechanism of GASD might relate to the
regulation of the glutamatergic functionthereby preventing the neurotoxicity of quinolinic acid.