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I have a 30GB 15M rows InnoDB MySQL 5.5.15 table. It is running on a server with many other MyISAM tables (300GB db). The system has 48GB RAM. Besides the default configurations, I've changed the following values:

InnoDB buffer pool to 10GB

log file size 5M

Note that my key_buffer_size of MyISAM is 8GB and I'm also allowing Memcache to use 8GB, and have Redis installed (not sure how much he takes).