Ann Arbor-based Tangent Medical Technologies Inc. announced today that it has received a Series A venture capital investment of $4.5 million, co-led by Arboretum Ventures of Ann Arbor and FlagshipVentures of Cambridge, Mass.

Also participating were several angel investors who previously invested in the company’s seed round and Osaga Ventures of Bala Cynwyd, Pa.

Tangent, a spinoff from the University of Michigan in 2009, is developing better catheter devices and related products for hospital patients. It expects to begin generating revenue in 2012.

Its CEO and chairman is Jeff Williams, who previously led two of Arboretum’s other portfolio companies: Ann Arbor-based HandyLab Inc., which was sold for $275 million, and Ann Arbor-based Accuri CytometersInc., which was sold for $205 million.

Tim Petersen of Arboretum and Harry Wilcox of Flagship both have joined Tangent’s board of directors.

Williams said Tangent plans to use the funding for regulatory filings with the U.S. Food and Drug Administration and for product development.