From Rindfliesch's discovery of the central vessel in the MS lesion in 1863, to CCSVI and the CNS lymphatic discovery. 160 years of research on blood flow, CSF, lymph and perfusion of the central nervous system.
Because the heart and the brain are connected.

Welcome! This blog contains research & information on lifestyle, nutrition and health for those with MS, as well as continuing information on the understanding of the endothelium and heart-brain connection. This blog is informative only--all medical decisions should be discussed with your own physicians.

The posts are searchable---simply type in your topic of interest in the search box at the top left.

Almost all of MS research is initiated and funded by pharmaceutical companies. This maintains the EAE mouse model and the auto-immune paradigm of MS, and continues the 20 billion dollar a year MS treatment industry. But as we learn more about slowed blood flow, gray matter atrophy, and environmental links to MS progression and disability--all things the current drugs do not address--we're discovering more about how to help those with MS.

To learn how this journey began, read my first post from August, 2009. Be well! Joan

Thursday, June 16, 2016

Readers of this blog will know I began writing about the vascular connection to MS after finding a link between Jeff's hypercoagulated serum test results, the small dots of blood seen on his legs called petechiae, and the realization that if he had pinpoint drops of blood escaping vessels on his legs, this could be happening in his brain, as well. Blood in brain tissue creates oxidative stress, causes demyelination and initiates the coagulation cascade. Dr. Roy Swank had noted the same thing in the 1950s, and had termed the leaky vessels "fragile capillaries." I brought this research into the 21st century, by linking this blood vessel fragility to endothelial dysfunction and issues with nitric oxide.Link

Finally, neurological researchers are noting the importance of cerebral microbleeds in the brains of those with MS, and exploring the cardiovascular connection to MS progression.

Published online today in Radiology, BNAC at the Jacobs School of Medicine in Buffalo reports on the link of cerebral microbleeds to disability in patients with MS. linkThe researchers found that the more cerebral microbleeds a patient had, the more severe were their physical and cognitive outcomes. In particular, MS patients who had more cerebral microbleeds had more physical disability after adjusting for age, hypertension and whole-brain volume.

"This is significant because it suggests that cerebral microbleeds are associated with increased physical disability in MS patients, independent from these additional risk factors for cerebral microbleeds," said Zivadinov.

In terms of cognitive disability, the researchers found that in the subgroup of MS patients who underwent neuropsychological testing, those with more cerebral microbleeds had higher disability on verbal and other cognitive function tests.

"Those MS patients who have cerebral microbleeds are subject to developing more physical and cognitive disabilities earlier in their disease, and therefore monitoring them more closely might be appropriate," Zivadinov noted.

Significant research is now being done on ways to combat cerebral microbleeds, Zivadinov said, adding that currently, prevention of cardiovascular risk factors was seen as the best way to prevent their formation since there are no currently available target therapies.

This is exactly why taking care of heart health is so vitally important. There are NO DRUGS to prevent cerebral microbleeds. It is why I created the Endothelial Health Program to combat all of the environmental factors which contribute to the weakening of the endothelial cells. A strong endothelium keeps blood inside vessels and stops micro bleeds. It's not a pill, it's a lifestyle.

The heart and brain are connected, and the research keeps coming in to prove this. I look forward to the day when cardiovascular and endothelial preserving therapies are the FIRST LINE treatment recommended to MS patients.

Wednesday, June 1, 2016

New research published in Neuron by the University of British Columbia finds an inherited genetic mutation related to rapidly progressing MS (PPMS). link Variants of the mutation are also seen in inflammatory vascular diseases. This research was first presented at ECTRIMS in 2015 link

The mutation of gene NR1H3 was found in seven of 2,000+ people with MS, and 70% of the people with this mutation went on to develop MS. Blood samples with this mutation were taken from two Canadian families who have members with primary progressive MS. Although this mutation is rare, it could an important marker for those diagnosed with PPMS, and help scientists understand the disease process behind PPMS.

This discovery relates to inflammation, lipids, and vascular health, as the NR1H3 gene encodes liver receptor protein A (LXRA) If there is a mutation, liver receptor proteins are dysregulated, lipids cannot be processed and inflammation occurs. But the UBC press release doesn't even mention this.

Now, understanding this information, here is Dr. Traboulsee on this discovery of an NR1H3 mutation in MS-

“If you have this gene, chances are you will develop MS and rapidly deteriorate,” said co-author Dr. Anthony Traboulsee, the MS Society of Canada Research Chair at UBC and Director of Vancouver Coastal Health’s MS and Neuromyelitis Optica Clinic. “This could give us a critical early window of opportunity to throw everything at the disease, to try to stop it or slow it. Until now, we didn’t have much basis for doing that.” link

What would part of this critical early window, "throw everything" treatment be?

A treatment program for someone with an NR1H3 genetic mutation--as we understand it in currently modeled studies of variants (link and link)

All of the above lifestyle interventions help counteract the influence of dysregulated LXR proteins by limiting damaging fats, decreasing inflammation, and strengthening the vascular endothelium; giving the heart, liver and brain their healthiest environment. It will not change the genetic mutation, but it can help modify and calm the body's inflammatory response. Today. link

Sounds a lot like what Dr. Roy Swank was publishing sixty years ago. link

Do you truly want to "throw everything" at this disease, and stop and slow MS progression, Dr. Traboulsee? Really?
Because there has been an incredible amount of research recently pointing to food and MS progression. The western diet harms the microbiome and increases inflammation linklink
and fasting reduces inflammation. link
In fact, your own colleague at UBC, Dr. Helen Tremlett, recently published on the inflammatory gut microbiota associated with children with MS. link

About Me

I became interested in multiple sclerosis (MS) research when my husband Jeff was diagnosed with MS in 2007. I noted a connection of Jeff's disease process to his circulation and blood, and by accessing medical journals on the internet and stacks of books at my local library, I put together research to address this. I sent my theory and research, called the Endothelial Health Program, to universities, and began a correspondence with vascular specialists at Stanford University.
Jeff was the first American treated for CCSVI, and he is now eight years past his venoplasty, with no further MS progression, healing of his gray matter, and relief of many symptoms. He's still jogging, working full time as a composer and conductor, and traveling the globe.