Phytosterol Supplementation

Summary

English medical professionals are instructed NEVER to advised patients to eat phytosterol enriched foods. On the other hand the Australian Heart Foundation recommends medical professionals advise patients to consume 2–3 g of phytosterols per day from margarine, breakfast cereal, reduced fat yoghurt or reduced fat milk enriched with phytosterols (approximately 2–3 serves per day of these enriched foods). See page 5 in this REPORT

It is true that these products and phytosterol supplements do lower ‘cholesterol’ but; the reason for lowering bad cholesterol is to reduce the risk of heart attack and stroke, but the science suggests these products may in fact INCREASE the risk of heart attack and stroke. Long term consumption may also cause other health issues. Let me explain.

What are Phytosterols.

Sterols are a class of molecules similar to a fat and play important roles in humans and plants. ‘Phyto’ is a fancy word for ‘plant’. Plant sterols employ important functions in plant biology. In humans the most well known sterol is cholesterol and it to performs important biological functions in humans. Most human cells can make cholesterol and we also get it from food.

Sterol Metabolism.

The components of food are absorbed in our small intestine. Cholesterol is absorbed by intestinal cells and pass through those cells for our use. Phytosterols are also absorbed but the intestinal cells recognise them as dangerous and reject them back into the intestine and they end up in our poop. This being said tiny amounts escape this rejection and end up in our blood. We humans have a second line of defense; our livers also recognise phytosterols and shunt them back into the intestine where most will be cleared to waste. Only infinitesimal amounts of phytosterol is retained when we we eat whole plant food.

A tiny number of people inherit very very rare genetic defect that disables the phytosterol rejection process discussed above. Without modern treatment or abstaining from plant food these people would likely die of heart complications, heart attack or stroke in their early twenties.

How do we know that these products and supplements do not reduce the risk of heart attack and stroke?

A drug called Ezetimibe has been developed that blocks the intestinal absorption of cholesterol by entirely different metabolic pathway than that of phytosterols. A clinical trial was performed comparing people at high risk of heart attack and stroke and were already taking a prescription drug called a statin (Simvastatin). The trial enrolled 18144 people and ran for seven years. One group (9077 people) took the statin alone, the other took the statin plus Ezetimibe. At the end of the trial people taking the Ezetimibe had lowered their bad cholesterol levels by a further 22.7%. But the risk of dying from a heart attack or suffering non-fatal heart attack or stroke was reduced by a much lesser amount being 1.9% and the risk of dying from any or all causes was only 0.65% You can read the report HERE.
If the same trial were carried out with Phytosterols instead of Ezetimibe the results would likely even be less effective than this and in our opinion people could be worse off than taking the statin alone. This is due to the actual and potential side effects of phytosterol supplementation, plus the phytosterol in margarines would lower bad cholesterol by 7% not the 22.7% mentioned above.

The Scientific Evidence Against Phytosterol Enriched Foods and Supplements.

“Elevations in sitosterol concentrations and the sitosterol/cholesterol ratio appear to be associated with an increased occurrence of major coronary events in men at high global risk of coronary heart disease.” http://www.ncbi.nlm.nih.gov/pubmed/16399487

And

Food supplementation with PSE impairs endothelial function, aggravates ischemic brain injury, effects atherogenesis in mice, and leads to increased tissue Sterol concentrations in humans. Therefore, prospective studies are warranted that evaluate not only effects on cholesterol reduction, but also on clinical endpoints. (Concentration of Plant Sterols) in Serum and Aortic Valve Cusps; NCT00222950)

“This study suggests that the high concentration of phytosterols in CA (Canola Oil) and the addition of phytosterols to other fats make the cell membrane more rigid, which might be a factor contributing to the shortened life span of SHRSP rats.

“To summarize, we have shown that an increase in cholesterol-standardized serum campesterol concentrations observed during long-term consumption of plant sterol ester enriched functional foods correlates with increase in retinal venular diameter. The functional consequences of the increase in retinal venular diameter in terms of affecting health demands further study, although the observed increase of 2.3 μm is certainly relevant when placed in perspective to associations found in for example metabolic syndrome subjects and smokers.”

All animals make cholesterol which is a sterol molecule. Could the replacement of cholesterol in our tissues by another sterol affect human health; the answer is yes.

“Triparanol, which inhibits a late step in the (cholesterol synthesis) pathway, was introduced into clinical use in the mid-1960s, but was withdrawn from the market shortly after because of the development of cataracts and various cutaneous adverse effects. These side effects were attributable to tissue accumulation of desmosterol, the substrate for the inhibited enzyme.”

Health Professional Clinical Guidelines.

English (UK) PS Guidelines

Guidelines are produced by the National Institute for Health and Care Excellence in conjunction with the National Clinical Guideline Centre. The guidance given to health professionals can be summarised as stating that under no circumstances should the practitioner advise clients to consume PS enriched food. The British guidelines can be found here.

Australian PS Guidelines

The Australian Heart Foundation (AHF) website contains contradictory information. A number of documents on the site (for both practitioners and the general public) recommend that 2 to 3 grams a day of Phytosterols be consumed for both primary and secondary prevention of CVD, the only exceptions being lactating women and children. Their statements are qualified with the following comments.

“There is no consistent evidence that would lead to safety concerns associated with the short-term consumption of phytosterols and stanols, although long-term safety studies have not been performed.”

“Long-term cholesterol-lowering studies with phytosterol intervention would be needed to demonstrate actual prevention of CVD, but are unlikely to occur.”

“Further work is needed to evaluate the effects of phytosterol-rich plant foods as a natural source of phytosterols that may lower cholesterol.”

“The role of phytosterols in modifying the development of atherosclerotic plaque warrants further research. Data will continue to be monitored by the Heart Foundation, especially with respect to potential adverse effects. Reduction in carotenoids and possibly tocopherols is one such area.”

Put into plain English the AHF is stating that they don’t know if PS enriched food consumption will reduce the chances of heart attack or stroke. The AHF is also stating that long term adverse safety risks are unknown. It could be said that the AHF is recommending an unsupervised epidemiological trial on the general public without their permission when adverse effects are known or certainly suspected with regard to humans.

“Several other interventions, including soya protein, phytosterols and selenium supplements, have been investigated for their potential benefits on CVD risk factors. In general, soya protein, phytosterols and soluble fibre may have modest hypocholesterolaemic effects, while there is insufficient evidence to determine the effect of selenium supplements on the prevention of CVD. More evidence is required before clear recommendations can be made regarding these interventions.”

Yet even though the AHF publishes the statement above it still recommends the consumption of PS enriched foods, and displays the “heart tick logo” on most of these products

Phytosterols and Secondary Cardiovascular Disease (CVD) Prevention.

The most common medication for secondary prevention of CVD are Statins. The AHF recommends that Doctors advise patients to also consume PS enriched foods in conjunction with the Statin treatment.Here the evidence is clear; consumption of PS enriched foods is likely to offer no further preventative benefit whatsoever; and may even reduce the efficacy of the Statin treatment.

This trial compared two groups of people over 7 years. One taking a Statin and the other taking the Statin plus a drug that blocks intestinal Cholesterol absorption (Ezetimibe) as does PS supplementation. Even though LDLc (bad cholesterol) was reduced by a further 28% in the Ezetimibe group, heart attack and stroke events were only reduced by a further 2% and there was no reduction at all in all cause mortality. Could this very marginal improvement also be provided by PS supplementation which also reduces LDLc absorption? The evidence suggests otherwise!

“We previously observed in apoE−/− mice that a diet supplemented with PSE (equivalent to a commercially available spread) induced endothelial dysfunction and led to an increase in ischaemic stroke size in wild-type mice.13 Moreover, we observed that inhibition of cholesterol absorption by a diet supplementation with PSE was associated with twice the amount of atherosclerotic lesion formation compared with ezetimibe treatment (a drug that reduces both plasma cholesterol and plant sterol levels), despite similar plasma cholesterol levels.

Based on the mice experiments it can be expected that PS cholesterol absorption blocking would be far less effective than the EZ cholesterol blocker and will have other detrimental effects (previously mentioned). Hence for secondary prevention of heart disease and stroke where persons are being treated with Statins; PS supplementation is not likely to have any measurable beneficial effect, and could even result in an increased risk.

Safety

PS molecules are very similar to, but not the same as, cholesterol. PS mimics cholesterol and is taken up in human cells at sites where cholesterol would normally be present. Had we known the detrimental effects of trans fats and cigarettes when first introduced, would we have allowed their free sale to the public?

Both the Australian Heart Foundation and Food Standards Australia state the long term health safety of PS supplementation is unknown, but much evidence exists to indicate health risks do exist. Considering this, the above information, and the fact that numerous alternative cholesterol lowering methods are available, why are PS supplements and PS enriched food freely available to the public? Even more amazing; why are these products allowed to be sold without a health warning, even if that warning be as feeble as the statements made by the AHF?

Conclusion

It is my contention that PS supplements and PS enriched foods should be removed from public sale and only be available on prescription. They are medicine not food.