Recurrent urinary tract infections (RUTIS) continue to be a major health problem in women and are now complicated by increasing antibiotic resistance. New preventive approaches are needed. Because most women with RUTI lack the normal protective Lactobacillus (LB) in their vaginal flora, we hypothesized that restoration of LB would reduce RUTIS. In this trail, women with recent UTI are randomized to receive either LB or placebo vaginal capsules and are followed for side effects, for colonization with LB and for occurrence of RUTI over hte next four months.

antifungal therapy fewer than seven days prior to the Randomization Visit

Antibiotics planned within four months

abnormal Pap smear requiring a procedure for diagnosis or treatment in the past 12 months

use of CTV-05 within one year of the Randomization Visit

menopause

use of a NuvaRing planned during the course of the study

any significant disease or acute illness that in the Investigator's assessment could complicate the evaluation

known HIV infection

immunosuppressive drug within 60 days

known allergy to any component of LACTIN-V or the placebo capsule

unavailable for follow-up visits

drug or alcohol abuse within past two years

any social or medical condition that, in the opinion of the Investigator, would preclude provision of informed consent, make participation in the study unsafe, complicate interpretation of study outcome data, or otherwise interfere with achieving the study objectives

Contacts and Locations

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study.
To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below.
For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00305227

Locations

United States, Washington

Hall Health Primary Care Center, University of Washington

Seattle, Washington, United States, 98195

Sponsors and Collaborators

University of Washington

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)