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Dipyridamole general information

Alcohol isn’t known to affect dipyridamole. It is ordinarily taken twice each day, 1 capsule each day and 1 within the evening. Keep taking aspirin and extended-release dipyridamole even should you feel well. Ingestion on a vacant stomach may cause higher blood levels.

A combination of the drug dobutamine and also a radiotracer might help to ascertain the activity degree of heart muscles as well as their viability. The patient was stable and also the auscultation unchanged before dipyridamole infusion. The aim of the test is always to see the method by which the heart functions at rest, and the way it functions when stressed. Caffeine intake and smoking should be avoided for no less than a day prior to and following the test.

You ought not utilize dipyridamole if you’re allergic to it. In case it is almost time for your subsequent dose, take just that dose. Just Take the missed dose once you remember. To assist you remember, take it at the exact same times daily.

Stress test is mostly carried out to determine how a certain body organ or system functions when it’s subjected to controlled quantity of stress. It creates an elevated oxygen demand within the heart muscles. The heart is, in addition, imaged beneath a normal resting state. It’s often prescribed alongside other medicines to stop blood clots.

There are numerous drugs that could interact with blood thinners. There might be different drugs that may affect dipyridamole. Doing this can release every one of the drug simultaneously, increasing the chance of side results. Dipyridamole is a drug being used over the previous 55 years to take care of different disorders, but now identified to have this remarkable new use.

Your physician or pharmacist might already be aware of any potential drug interactions and might be monitoring you for them. Be certain that you inform your doctor of any healthcare conditions you might have, or some family history of health issues. Visit your family doctor or doctor for regular checks on your own progress. Patients must inform the physician about their healthcare history, allergies, and any medicines that they’re taking.

You may accidentally consume too a lot of specific drug. Don’t use this medication in case you are allergic to dipyridamole. Some items might interact with your medicine. You’ll find a complete list in the company’s information leaflet supplied with your medicine.

If you purchase any medicines for cold or pain relief, check using a pharmacist to begin with to be sure they don’t contain aspirin. A lot of people employing this medication don’t have serious side outcomes. The dosage is dependent on your healthcare condition and response to treatment. This medication shouldn’t be used in case you have certain health conditions.

Don’t begin utilizing a different medication without telling your own doctor. Don’t start or stop employing any medicine without consulting your own doctor. Call your physician for medical advice regarding side effects. If you see other effects not listed above, get in touch with your physician or pharmacist.

Tell your physician in case you are pregnant or intend on becoming pregnant during treatment. In case you have any doubts or concerns you’re advised to talk about the medicine with your personal doctor or pharmacist. Don’t take your medicine more frequently than directed. Aside from that, it can help to decide the treatment techniques to be followed and keep an eye on the effects of the treatment too.

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Active – active substance / start: dipyridamole

Dipyridamole – an effective and safe antiaggregant and angioprotector for lifelong use in cardiology and Angiology. It is used to treat coronary heart disease, chronic coronary insufficiency, cerebral circulatory disorders, vascular encephalopathy, arterial and venous thrombosis, occlusive diseases of the lower limbs, for any violations circulation, as well as an interferon inducer and an immunomodulator. The combined use of dipyridamole and anticoagulant therapy is indicated in patients with prosthetic heart valves.

is effective at any dose regimen;

rapid antiplatelet effect;

does not require a thorough laboratory control;

safe during pregnancy;

cost effective.

Active – active substance: Dipyridamole / Dipyridamole.

Dosage Forms: Drops. Tablets. The solution for injection.

Dipyridamole

Properties / Action: Dipyridamole – antiagregatine, angioproteguoe, an immunomodulatory agent. Dipyridamole inhibits adenosine deaminase competitive, contributing to the accumulation of adenosine that participates in the regulation of coronary blood flow, as well as the ability of platelets to aggregation and adhesion.

blocks phosphodiesterase and increases levels of cAMP in the cells.

increases the concentration of adenosine and ATP synthesis in the myocardium, improving its contractility.

improves the supply of blood and oxygen to myocardial cells, causing the maximum dilatation of the coronary vessels; lowers the resistance of the coronary arteries at the level of small arms and arterioles.

increases the number of collaterals and collateral blood flow in the myocardium.

reduces round, lowers blood pressure.

has an anti-clotting action based on inhibition of platelet adhesion and aggregation, which are factors determining the beginning of thrombus formation, as well as an increase in the length of time shortened platelet life. Dipyridamole affect the functional activity of platelet prostacyclin by increasing effect by inhibiting phosphodiesterase and adenylate cyclase stimulation and suppression of the formation of thromboxane A2, which is known to induce platelet adhesion and aggregation; improves microcirculation, prevents arterial thrombosis.

normalizes venous outflow.

reduces the resistance of cerebral vessels.

corrects the placental blood flow; the threat of pre-eclampsia prevents degenerative changes in the placenta, fetal tissue eliminates hypoxia, contributes to the accumulation of glycogen.

has a modulating effect on the functional activity of interferon enhances the non-specific antiviral resistance to viral infections.

Managed antiplatelet and antithrombotic effect due to:

the activation of adenylate cyclase;

the inhibition of platelet phosphodiesterase;

the normalization of relations and PG I2 TxA2;

reduction of Ca ++ in platelets. vasodilation and increased blood flow through the arteries and collaterals available due to:

the activation of synthesis of prostacyclin (PG I2) endothelium;

Gain synthesis of endothelial nitric oxide (NO); The increase in capillary density and intensity of collateral blood flow due to:

stimulation of adenosine A1 – and A2 – receptor;

Gain synthesis endothelial growth factor and angiogenesis. The improvement of microcirculation due to:

collateral flow correction;

improve the deformability of red blood cells.

Pharmacokinetics: Rapidly absorbed from the stomach (the majority) and small intestine (small amount). Almost completely bound to plasma proteins. Cmax – within 1 h after administration. T1 / 2 – 20 – 30 min. It accumulates primarily in the heart and erythrocytes. It is metabolized by the liver by binding with glucuronic acid, is excreted in the bile as monoglyukuronida.

Indications:

coronary heart disease, chronic coronary insufficiency;

the treatment and prevention of disorders of cerebral circulation;

encephalopathy;

prevention and treatment of arterial and venous thromboses and their complications;

the treatment and prevention of DIC – syndrome in children with infectious toxicosis and septicemia;

three-component treatment of glomerulonephritis (complex therapy);

in the complex therapy of any violations of the microcirculation; all states in which the reduction in the adhesiveness and platelet aggregation is considered to be therapeutically useful;

as an interferon inducer and immune modulator for the prevention and treatment of influenza, SARS;

holding dipyridamole – thallium scintigraphy, dipyridamole stress – echocardiography. In the combined use with acetylsalicylic acid, dipyridamole enhanced antithrombotic effect. The combined use of dipyridamole and anticoagulant therapy is indicated in patients with prosthetic heart valves.

Dosage and administration: Oral: The inside is not liquid, squeezed small amounts of liquid. Oral dosage forms of the drug should preferably be taken on an empty stomach, one hour before a meal. For treatment of coronary insufficiency assigned dose 150 – 225 mg per day, divided into 3 – 6 techniques (possibly in combination with oral anticoagulants or acetylsalicylic acid). Treatment should be long-term, dose can be increased if needed and if tolerated. For the treatment of conditions that require a significant inhibition of platelet adhesion and aggregation, the dose is in the range 300 – 450 mg / day, divided into 3 – 6 receptions. In severe cases, the total dose may be increased to 600 mg. For the prevention of influenza and acute respiratory viral infections, especially during epidemics: 50 mg / day, once, 1 time per week for 4 – 5 weeks. To prevent a recurrence, in sickly respiratory viral infections of patients: 100 mg / day according to the scheme: 50 mg 2 times a day with an interval of 2 hours, 1 time per week for 8 – 10 weeks. To prevent thromboembolic syndrome, thrombosis and stent aortocoronary grafts – the first day, 50 mg 4 times / day with aspirin, then – 100 mg of 4 times / day (canceled 7 days after surgery subject to continued aspirin 325 mg / day). Another possible scheme: 100 mg four times a day for 2 days before surgery, and 100 mg of 1 hour after the operation (if necessary in combination with warfarin). For the treatment of chronic obliterating diseases of lower limb arteries – 75 mg 3 times a day; treatment 2 – 3 months (it is advisable to combine with low-dose aspirin). For diagnostic purposes – 300 – 400 mg directly during stress – echocardiography or 45 min before injection of the radiopharmaceutical. Parenteral use: In case of failure of oral administration (eg, during or after surgery), dipyridamole may be administered parenterally. In such cases it is recommended to carry out the slow I / drug infusion of 5 mg / kg body weight per day. The infusion rate should not exceed 200 g / min. (= 12 mg / hour). The daily dose – 150 – 200 mg. Dipyridamole can be dissolved in 5% glucose solution. Taking into account the physico – chemical properties of dipyridamole, it should not be mixed with other drugs. Use in children: It is generally recommended total daily dose of 5 – 10 mg / kg body weight.

Use during pregnancy and lactation: Long experience with dipyridamole did not find any – any signs of adverse effects of the drug during pregnancy. However, you should take the usual precautions regarding the use of drugs in this period, especially during the first trimester. Safety of the drug during lactation We establish was not.

Side effects: usually occur in the early stages of treatment, and are often associated with the wrong dose. It is extremely rare (at doses not exceeding 200 mg / day), nausea, dyspepsia, buzzing in the ears, dizziness, headache, transient facial flushing; pain in the heart, coronary artery steal syndrome (CHD exacerbation), tachycardia – or bradycardia, hypotension (with the rapid on / in the introduction); pain in the liver area, changes in the functional properties of platelets, bleeding; allergic skin reactions, itchy skin.

Special instructions and precautions: Dipyridamole is a potent vasodilator and should be used with caution in patients with rapidly progressive angina subvalvulyarnym aortic stenosis or hemodynamic instability (eg, associated with recent myocardial myocardial infarction). Intravenous Dipyridamole is not recommended in shock or collapse of states. If you have coronary steal syndrome to improve intracardiac blood flow shows the assignment and aminophylline. To reduce the dipyridamole in the stomach and nausea, gravity can be taken with milk. of the liver and biliary tract obstruction necessitate dose reduction. If pregnancy should strictly determine if the use of the drug, especially in II and III trimesters. Avoid the use of natural coffee and tea (possibly weakening effect).

Drug Interactions: The xanthine derivatives, caffeine. reduce the effectiveness of dipyridamole. In an application with oral anticoagulants and aspirin. as well as the antibiotics penicillin, cephalosporins, tetracycline om, om chloramphenicol antiplatelet effect of dipyridamole enhanced. If using dipyridamole in combination with acetylsalicylic acid or anticoagulants. It should take into account a possible intolerance to these drugs, and the associated risk. Heparin increases the risk of bleeding complications. increases the hypotensive effect of antihypertensive drugs, weakens the anticholinergic properties of cholinesterase inhibitors. Antacids reduce the maximum concentration of the – due to lower absorption. An injectable solution of dipyridamole is not mixed with other medications (eg, alkaline solutions) in the same syringe.

Storage: List B. In the dark place at room temperature. Holidays from the pharmacy – prescription.