Marvel Universe LIVE! will captivate audiences with an authentic and original story that brings more than 25 Marvel characters together on one epic quest. The story is framed around the battle over the Cosmic Cube, the source of ultimate power and one of the most feared and coveted treasures in the Marvel Universe, that has been shattered into pieces by the Mighty Thor in order to prevent it from falling into the wrong hands. With the pieces scattered across the globe, Thor's villainous brother Loki devises a scheme to clone its powers, inciting a threat that could not only decimate Earth but also obliterate the Universe.

To defeat Loki, Marvel's biggest Super Heroes must band together, including The Avengers – Iron Man, Captain America, Hulk and Thor along with Spider-Man and Wolverine, must trek across the globe to retrieve the Cosmic Cube fragments and unite them. As the Super Heroes track the Cube, they will encounter some of their biggest adversaries including Green Goblin, Doctor Octopus, Red Skull, Madame Hydra, Aldrich Killian, Electro and more, in the quest for the very same fragments. These foes have no problem teaming up if it gets them closer to their ultimate goal of world domination.