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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The astroglial water channel aquaporin (AQP4) is essential for the maintenance of BBB integrity.52 Antibodies to AQP4 have a highly specific role in neuromyelitis optica (NMO) and characteristically bind to cerebral microvessels, pia mater and VRSs.53 Secretin is important for other aquaporin expression via vasopressin, secretin receptor-null mice for example have reduced renal expression of AQP2 and AQP4.54 Thus VIP impairment may influence water channel function.