Abstract: Furosemide is a loop diuretic that has been administered
intravenously for years; however, its chemical stability has
been determined only at dilute concentrations. The stability
of furosemide diluted with 0.9% sodium chloride injection,
and stored at either 22°C or 6°C in minibags (60, 120, and 160
mg/50mL) and polypropylene syringes (10, 20, 40, and 80
mg/10 mL) and protected from light was studied. Samples
were collected in triplicate on days 0, 3, 7, 14, 28, 56, and
84 and then after exposure to fluorescent light for an additional
7 days at 22°C. All samples were analyzed in duplicate
by means of a stability-indicating high-pressure liquid chromatographic
assay. Samples were also monitored for color,
clarity, and changes in pH. All samples remained clear and
colorless during the study period. The pH of the solutions
did not change significantly during the study. All analyzed
samples were stable for 84 days at 22°C or 6°C when protected
from light and for an additional 7 days at 22°C when exposed
to fluorescent light.