Ignacio Serricchio és Don West, a mechanic who also smuggles luxury goods. He has a chicken named Debbie, which he claims to be lucky.[9]

Parker Posey és la Dra. Smith/June Harris. She is a criminal and a psychopath who uses other people's identities to claim their belongings. Dr. Smith, whose real name is June Harris, stole her sister Jessica's identity and place on the colony ship. There she impersonates Dr. Zachary Smith, to take his seat on an evacuating Jupiter ship. After landing on the planet, Dr. Smith attempts to sabotage the Jupiters' chances of being rescued by the Resolute while manipulating and gaslighting the survivors to avoid prosecution for her crimes.[10] The theft of the doctor's identity is a reference to the corresponding Dr. Smith character of the original TV series.[11]

Brian Steele és el Robot,[12] an alien mechanoid being that Will encounters on the planet that his family crash lands on. The robot has a different form from the ones on the previous series and movie.[13]

Raza Jaffrey és Victor Dhar, un instruït i autoritari home molt segur de si mateix. Victor has been a career-builder and politician from a young age. His arrogance and impatience masks an underlying fear that it will be discovered that he is not quite good enough.[15]

La gran nau espacial Resolute amb forma de roda de fira està transportant colons, incloent la família Robinson, cap a Alfa Centauri. La Resolute és atacada i els colons escapen en les petites naus/llars familiars Júpiter landing crafts but are hurled into a wormhole, crash-landing on an Earth-like planet. The Robinsons' craft, Jupiter 2, crashes into a glacial bed. The family evacuates with some supplies before their craft sinks in rapidly freezing water. Eldest Robinson child, Judy, a doctor, dives to the ship to retrieve power equipment. She becomes encased in ice, and with five hours of oxygen left in Judy's suit, John and son, Will, set out to collect magnesium that will melt the ice. Judy guides her sister, Penny, through a medical procedure to treat their injured mother, Maureen. Inside a cave, Will falls down a chasm, landing at the edge of a forest. John radios Will, saying he will return after saving Judy. Alone, Will finds a crashed alien ship and a dismembered robot that he helps to self-repair. In return, it saves Will as a forest fire nearly engulfs them. The family attempt to free Judy, but a sudden rainstorm hinders their progress. Will and the Robot arrive, and the Robot rescues Judy. In a flashback scene, a woman steals the identity of Dr. Zachary Smith and boards a Jupiter landing craft, along with Don West and Tam Roughneck.