Weitere Antikörper gegen Hyaluronan Synthase 2 Interaktionspartner

Zebrafish Hyaluronan Synthase 2 (HAS2) Interaktionspartner

Fgf signaling is required early, from 6 to 10h pf,for has2 activation. Loss of has2 results inthe loss of the chondrogenic program resulting in postchordal neurocranial defects in Fgf loss-of-function embryos. Shh (zeige SHH Antikörper) is not essential for this early activation of has2.

propose here a rather unique role of Med10 (zeige MED10 Antikörper) in orchestrating cardiac valve formation by mediating Foxn4 (zeige FOXN4 Antikörper) dependent tbx2b transcription, expression of Has2 and subsequently proper development of the cardiac jelly

MiR-23 is both necessary and sufficient for restricting the number of endocardial cells that differentiate into endocardial cushion cells by inhibiting Has2 and extracellular hyaluronic acid production.

these results highlight the role of nSMase2 in apoptosis evoked by nutrient starvation that could contribute to the delayed apoptosis of hypertrophic chondrocytes in the growth plate, and emphasize the antiapoptotic properties of HAS2

Reduced expression of HAS1 (zeige HAS1 Antikörper) and HAS2 is associated with melanoma progression and suggests that HAS1 (zeige HAS1 Antikörper) and HAS2 have a prognostic significance in cutaneous melanoma.

The present data reveal a selective up-regulation of HAS2 expression by extracellular Uridine Triphosphate, which is likely to contribute to the previously reported rapid activation of hyaluronan metabolism in response to tissue trauma or ultraviolet radiation.

HAS2 and HAS3 (zeige HAS3 Antikörper) were the only hyaluronan synthases detected, the expression of which was almost similar in NPs (zeige NPS Antikörper) and NM.

HAS2 has been proposed to be a target for therapeutic intervention in cancer. Our findings suggested a possible antagonistic role of androgen receptor (AR (zeige AR Antikörper)) pathway on HAS2 function.

Xenopus laevis Hyaluronan Synthase 2 (HAS2) Interaktionspartner

In the absence of XHas2, early myoblasts underwent apoptosis, failing to complete their muscle differentiation programme. XHas2 activity is also required for migration of hypaxial muscle cells and trunk neural crest cells (NCC (zeige SLC12A3 Antikörper)).

Hyaluronan Synthase 2 (HAS2) Antigen-Profil

Beschreibung des Gens

Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded through pore-like structures into the extracellular space. It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with tumor metastasis. HAS2 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology to glycosaminoglycan synthetase (DG42) from Xenopus laevis, and human and murine hyaluronan synthase 1.