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Perspective

Receptor Cross Talk: Ligand-Gated Ion Channels Start to Communicate

Nicholas J. Brandon and

Stephen J. Moss

The authors are at the Medical Research Council Laboratory of Molecular Cell Biology and Department of Pharmacology, University College London, Gower Street, London WC1E 6BT, UK. E-mail: steve.moss{at}ucl.ac.uk

The authors are at the Medical Research Council Laboratory of Molecular Cell Biology and Department of Pharmacology, University College London, Gower Street, London WC1E 6BT, UK. E-mail: steve.moss@ucl.ac.uk

The authors are at the Medical Research Council Laboratory of Molecular Cell Biology and Department of Pharmacology, University College London, Gower Street, London WC1E 6BT, UK. E-mail: steve.moss@ucl.ac.uk

Abstract

Evidence is mounting for a direct mode of interaction between neurotransmitter receptors that modulates the activity of the interacting proteins. Brandon and Moss discuss two examples in which direct interactions between neurotransmitter receptors appear to regulate the receptors independently of the signal transduction cascades they activate. This type of interaction has important implications for rapid modulation of receptor function and the integration of multiple signals at a synapse.