Frank (Johnny Depp) is an American tourist visiting Italy to mend a broken heart. Elise (Angelina Jolie) is an extraordinary woman who deliberately crosses his path in order to mislead all those following her former lover, Alexander Pearce, a criminal wanted in fourteen countries who has stolen money from a gangster (Steven Berkoff) and is being pursued by an agent (Paul Bettany). Against the breathtaking backdrop of Venice, Frank attempts to forge a potential romance but soon finds himself a target as he and Elise are caught in a whirlwind of intrigue and danger. :)