Cristiano Ronaldo has fond memories of knocking out Atletico Madrid in the Champions League. Juventus signed the 34-year-old for these occasions and there will be pressure on him to guide the Old Lady through to the next round.

Simeone has confirmed Koke is back from injury but faces competition from Thomas Lemar for a place in the starting XI.

Having confirmed one of Koke or Thomas Lemar will start, that suggests one of Thomas Partey, Saul Niguez or Rodrigo will have to settle for a place on the bench. Place bet on Live Event 24/7 on NaijaBet

Jose Gimenez and Stevan Savic compete for a spot at centre-back, while Alvaro Morata should start against former club Juventus.

Bayern Munich struggled to overcome Augsburg on Friday night, twice coming from behind, but Niko Kovac admitted his side made the mistake of looking ahead to their match with Liverpool instead of focusing on Augsburg.

Liverpool- Virgil van Dijk is suspended for the first leg of Liverpool’s last-16 tie with Bayern Munich and that is a huge blow for Liverpool. Fabinho will partner Joel Matip at the back if Dejan Lovren fails to recover from injury in time.

Barcelona are unbeaten in their last six but have drawn three of their last four in all competitions. They have struggled to score goals in recent matches, failing to net more than once in each of their last three outings. That will be a concern for Ernesto Valverde.

Dortmund were pegged back from 3-0 down to draw 3-3 with Hoffenheim at the weekend and have now failed to win in three in all competitions. The German giants won two of their three away group stage matches, with their sole defeat coming in their toughest test at Atletico Madrid.

Valencia cannot improve on a third-place finish and are also four point clear of bottom side Young Boys. They held United to a draw at Old Trafford in the reverse fixture and will hope to do at least the same here against an experimental United XI.

Valencia- Jose Gaya is suspended for Valencia, while Daniel Parejo, Carlos Soler and Geoffrey Kondogbia are one booking away from a one-match ban in the Champions League.

Gabriel Paulista was forced off with an injury in Valencia’s 1-1 draw with Sevilla at the weekend and is unlikely to feature against Manchester United on Wednesday. Live Bet are available on NaijaBet 24/7

BSC Young Boys- Sekou Sanogo is suspended for Young Boys, while Loris Benito and Kevin Mbabu are one booking away from a one-match ban. Steve Von Bergen, Gregory Wüthrich and Jordan Lotomba are doubts for the home side. Bet Now

Napoli needs only to avoid defeat to secure their place in the next round of the Champions League and come into this clash in the midst of a 12-match unbeaten run. They’ve won three of their last four away matches and won the reverse fixture courtesy of a late Lorenzo Insigne strike.

Tottenham bounced back impressively from a 4-2 loss to Arsenal last weekend with back-to-back wins over Southampton and Leicester. Victories over PSV and Inter at Wembley kept their hopes of progression alive, but they face an uphill task to secure their spot in the next round of the Champions League.

With that in mind, it’s difficult to predict the outcome of Wednesday’s mouthwatering encounter. PSG need to win these games to prove they are elite in Europe and they would certainly fancy their chances more if Neymar and Mbappe play.

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Paris Saint-Germain- Neymar and Kylian Mbappe are huge doubts for Wednesday’s must-win fixture against Liverpool, though PSG Thomas Tuchel has confirmed both will start. Latest Odds

Inter have lost two of their last three away matches in all competitions, but bounced back from the disappointing 4-1 loss to Atalanta prior to the international break with a comprehensive 3-0 win over Frosinone at the weekend.

Young Boys are bottom of Group H with one point from four matches. They can technically still finish third but that would require beating United and Juventus, which is unlikely.

United have largely been abysmal this season but should try and use this match to get some confidence in front of goal. Anything other than a comfortable victory would heap further pressure on Mourinho. Place on today on Games on NaijaBet

City’s sole defeat this season came at the hands of Lyon, yet since that loss, they have failed to win only one of their last 13 competitive matches, that coming in a 0-0 draw with Liverpool, a match they could have won late on. They’re yet to lose an away match this season, so should be confident of prolonging that unbeaten streak.

United are still in second after Valencia surprisingly only managed a draw with group minnows Young Boys last time out. Valencia host the Swiss side in the group’s other game and United have to assume they will win this time. Jose Mourinho’s side could well be third by the end of play.

They are still in a good position in second and one point behind Liverpool but you have to assume the Reds will beat minnows FK Crvena Zvezda in the group’s other match. The winner of this match will likely go through to the next round.

Aside from beating Chelsea at Stamford Bridge, the only teams PSG have managed to beat from home in the Champions League from their last 20 attempts are Anderlecht, Celtic, Basel, Ludogorets, Malmo, Shakhtar Donetsk and APOEL.

Barcelona has a perfect record in Group B after three matches and have won five matches in a row in all competitions. Their last two outings have been a struggle, however, only beating Leganes 1-0 and Rayo Vallecano 3-2.

Inter are unbeaten in three home games against Barcelona (W1, D2). They are in great form at the moment and will be even more confident of getting a positive result if Lionel Messi is only named as a substitute.