Transcription factor Efg1 contributes to the tolerance of Candida albicans biofilms against antifungal agents in vitro and in vivo

Journal of Medical Microbiology, 05/16/2012Bink A et al.

The increased sensitivity to miconazole was, at least, partly due to an increased accumulation of miconazole in the cells as compared to wild–type or reintegrant Δefg1(EFG1) sessile cells. By using a rat biofilm model, authors further confirmed the role of Efg1 in the tolerance of C. albicans biofilms to miconazole when grown in vivo.