This was the fourth pregnancy of a nonconsanguinous couple. The first sonographic screening was abnormal at 8 weeks. We suspected acrania. At 10 weeks, by ultrasound, the fetus presented several anomalies : Absence of the skull and acrania (Image 1,2,3).

At 10 weeks and 2 days, cardiac activity was absent. We performed an embryoscopy and confirmed an acrania. We also observed rachischisis and a probable cleft lip. A curetage was done then. The karyotype could not be obtained after trophoblast biopsy.