Abstract

BACKGROUND AND PURPOSE: Hospitals struggle to provide care for elderly patients based on Medicare payments. Amid concerns of inadequate reimbursement, we sought to evaluate the hospitalization costs for recipients of CEA and CAS placement, identify variables associated with increased costs, and compare these costs with Medicare reimbursements.

MATERIALS AND METHODS: All CEA and CAS procedures were extracted from the 2001–2008 NIS. Average CMS reimbursement rates for CEA and CAS were obtained from www.CMS.gov. Annual trends in hospital costs were analyzed by Sen slope analysis. Associations between LOS and hospital costs with respect to sex, age, discharge status, complication type, and comorbidity were analyzed by using the Wilcoxon rank sum test. Least-squares regression models were used to predict which variables had the greatest impact on LOS and hospital costs.

RESULTS: The 2001–2008 NIS contained 181,200 CEA and 12,485 CAS procedures. Age and sex were not predictive of costs for either procedure. Among favorable outcomes, CAS was associated with significantly higher costs compared with CEA (P < .0001). Average Medicare payments were $1,318 less than costs for CEA and $3,241 less than costs for CAS among favorable outcomes. Greater payment-to-cost disparities were noted for both CEA and CAS in patients who had unfavorable outcomes.

CONCLUSIONS: The 2008 Medicare hospitalization payments were substantially less than median hospital costs for both CAS and CEA. Efforts to decrease hospitalization costs and/or increase payments will be necessary to make these carotid revascularization procedures economically viable for hospitals in the long term.

ABBREVIATIONS:

ARF

acute renal failure

CAS

carotid artery stent

CC

comorbid condition

CCS

clinical classification software

CEA

carotid endarterectomy

CHF

congestive heart failure

CMS

Centers for Medicare & Medicaid Services

COPD

chronic obstructive pulmonary disease

CREST

Carotid Revascularization Endarterectomy versus Stent placement Trial

CRF

chronic renal failure

CV

cardiovascular

CVD

cardiac valve disease

DM

diabetes mellitus

DRG

diagnosis related group

GAPICC

group average payer inpatient cost-to-charge

HCUP

Healthcare Cost and Utilization Project

HHC

home health care

HLD

hyperlipidemia

HSD

honestly significantly different

HTN

hypertension

ICD9

international classification of diseases, 9th edition

IQR

interquartile range

LOS

length of stay

MI

myocardial infarction

NIS

National Inpatient Sample

SNF

skilled nursing facility

STH

short-term hospitalization

Carotid revascularization therapies have been shown to reduce the incidence of stroke among patients with atherosclerotic carotid artery stenosis.1 Although CEA remains the most common surgical method for revascularization, CAS deployment has gained support over the past decade. Outcomes from the recent CREST revealed that patients older than 69 years of age had better outcomes with CEA, while patients younger than 69 years of age had better outcomes with stent placement.2 Although the results from CREST demonstrate clinical utility for both therapeutic modalities, particularly among asymptomatic presentations, scant large-scale data exist to identify potential disparities between costs and reimbursements among both favorable and unfavorable postoperative outcomes. As asymptomatic presentations represent most revascularization procedures and are more likely to have fewer confounding peri-procedural cost variables, we focused our cost analysis on this subset of individuals. In the current study, we evaluated the NIS data from 2001 to 2008 to ascertain costs associated with hospitalization for carotid revascularization in asymptomatic patients in order to identify variables predictive of hospital costs and to determine if Medicare reimbursements are sufficient to account for these costs.

Materials and Methods

Data Acquisition

ICD-9 procedure codes were used to independently identify cases of CEA (38.12, available from 2001–2008) and CAS (00.63, available from 2004–2008) from the 2001–2008 NIS hospital discharge data base (Healthcare Cost and Utilization Project of the Agency for Healthcare Research and Quality, Rockville, Maryland).3 Age, sex, discharge status (including in-hospital mortality), LOS, total hospital charges, and hospital-specific mean cost-to-charge ratios were extracted from the NIS dataset for each procedure (CEA, CAS). Discharge status was grouped into 3 categories: “unfavorable discharges” requiring skilled care (STH, SNF, HHC), “favorable discharges” to home, and “in-hospital mortality.”

Hospital costs were the primary end point examined in this analysis. Hospital costs were determined by multiplying the total hospital charges, documented in the NIS core file, by the weighted GAPICC ratio for each hospital on record in the NIS annual hospital file data.4 This conversion was performed to account for differences in operational expenses and billing practices. Inflation adjustment over the 8-year period was performed by using the consumer price index calculator,5 and total costs were adjusted to 2008 US dollar amounts unless otherwise specified. Medicare reimbursement schedules were obtained from the CMS Web site.6

Statistical Analysis and Multivariate Regression Models

All statistical analyses were performed by using software (JMP, version 9; SAS, version 9; SAS Institute, Cary, North Carolina). Significance was estimated by using a P value of less than .05. Data were presented as median scores with IQR due to non-normal data distributions, unless otherwise specified.7 Trends over time in hospital costs were detected by using the Sen slope method (Q score) as a test for both magnitude and significance.8 Significant relationships between costs and potential predictors were determined by using the Wilcoxon signed-rank test. Significant differences among 3 or more data groupings (discharge status, comorbidity) were determined by using ANOVA tests. Post hoc Tukey HSD tests were performed on significant ANOVA results to identify significant paired comparisons.

Predictors of hospital costs and lengths of stay for CEA and CAS were determined via multivariate standard least-squares regression analysis by using an identity-linkage function. Age, sex, discharge status, complications, and comorbidities were transformed to binary responses and treated as effect variables in these 3 models. Estimate coefficients found to be significant represented the predicted change in predictor variable (LOS or cost) for every unit change in effect variable. Predicted intercept data were presented as the unadjusted response variable for each model in the modified Forest plot. Adjustment from each estimate variable was shown as a deviation from this baseline value.

Results

Demographic, Outcome, and Cost Data

Among asymptomatic cases retrieved from the 2001–2008 NIS, 181,200 CEA procedures and 12,485 CAS procedures were recorded within 57,663,486 hospital admissions records, representing 0.31% and 0.02% of all recorded hospitalizations, respectively. The demographic characteristics and hospital outcomes, including cost, length of stay, and discharge status of patients undergoing these therapies, are shown in Table 1.

LOS Analysis

The relationship between patient and outcome variables with LOS, sorted by revascularization procedure, is shown in Fig 2A. Significance for each intervariable (CEA vs CAS) and paired-variable response test (CAS variable 1 vs 2, CEA variable 1 vs 2) is shown separately. When CEA and CAS were examined separately, female sex (CEA only), age >69 years of age (CEA only), and unfavorable discharges (CEA and CAS) were associated with significantly increased LOS relative to males, age <69, and discharges to home, respectively. For both procedures, stroke was associated with significantly longer LOS relative to CV complications, and severe comorbidities (ARF, MI, CHF) significantly increased LOS by as much as 10–12 days relative to less severe comorbid conditions (DM, HTN, HLD). When CEA and CAS were directly compared, recipients of CAS had significantly shorter LOS among both genders, age strata, patients discharged to home, and among selected comorbidities (CRF, CHF, COPD, DM, HTN, HLD). Lengths of stay among unfavorable discharges and among procedures associated with postoperative complications were not significantly different between CEA and CAS.

Predictors of length of stay and hospital costs for CEA and CAS by using multivariate regression analysis. Regression estimates for demographic and treatment variables for CEA (blue) and CAS (red) are shown for LOS (A) and 2008-adjusted hospital costs (B). The unadjusted response variable for each model, representing the baseline model value, is represented by the vertical colored lines (CEA, blue; CAS, red). Variable adjustments are shown by positive or negative bar-graph deflections from this baseline value. Regression results for each model are shown. Significance for each variable is coded as follows: ****P < .0001; ***P < .001; **P < .01; *P < .05; NS P ≥ .05).

Medicare Payment versus Hospital Cost Analysis

Data from the 2001–2008 NIS data base revealed that the 2008 adjusted cost of hospitalization with a favorable discharge outcome were $7,375 for endarterectomy and $12,668 for carotid stent placement. The median costs for uncomplicated CEA and CAS were $1,466 and $3,272 more than the average 2008 Medicare payments for CEA and CAS, respectively (Table 2). Complications and comorbidies added to the hospitalization costs (Figs 2 and 3). For example, patients with chronic renal insufficiency, a minor CC, incurred median hospitalization costs of $10,802 for CEA and $15,216 for CAS; and patients with myocardial infarction, a severe comorbid condition, incurred median hospitalization costs of $35,657 for CEA and $35,529 for CAS. The disparities between hospitalization costs and Medicare payments were substantially higher among these complicated discharges. Based upon our findings, median hospital costs exceeded average Medicare payments as follows: $2,847 for CEA and $4,926 for CAS in cases involving intermediate CC, and $23,399 for CEA and $21,750 for CAS in cases with severe comorbid condition complications.

Discussion

Our study reveals that, even among the cohorts for which costs would be most modest, for example, patients with the best clinical outcomes, Medicare reimbursement is substantially less than costs incurred by hospitals associated with CEA and CAS procedures. Furthermore, the hospitalization costs associated with CAS are approximately $5,000 higher than CEA for patients with favorable outcomes. Presumably, this relates, in large part, to costs of the endovascular devices used for CAS. However, the average 2008 Medicare payment for an uncomplicated CAS (DRG 36) was only $3,287 more than the payment for uncomplicated CEA (DRG 39), so hospitals may be at more risk for financial loss with CAS than with CEA.

Beginning in 2008, Medicare payments for CAS and CEA changed to account for patients with moderate and major comorbidities and complications (Table 2). Among uncomplicated procedures representing 90% of all cases examined, the 2008 modifications to the Medicare reimbursement schedule continue to inadequately cover even the most favorable outcomes. The remaining 10% of procedures involved complications and comorbidities that were anticipated to lengthen hospitalization and increase fees. In these cases, where hospital fees were 4 or more times higher than favorable outcomes, 2008 Medicare payment rates result in an even larger disparity between cost and reimbursement. Because the Medicare payment schedule is not designed to keep pace with the inflationary trends in hospitalization costs, the disparity between payments and costs would not be expected to improve over time.

Finally, our data show that in-hospital death, though uncommon, incurs the highest median hospital costs and displays the widest interquartile range. This observation suggests that hospitals vary considerably with respect to their management of the most severe complications. Because in-hospital death was not associated with the longer lengths of stay, we assume these additional fees are a result of additional procedural interventions. These data further demonstrate that the difference between hospital costs and Medicare payments is larger for major complications and argue for revision and/or restratification of the complication reimbursement schedule.

This study has several limitations due to utilization of an extremely large retrospective data base with a predefined data structure. First, coding errors are a well-established limitation of such data sources and have been shown to exist within the NIS data.9 Yet it has been suggested that such errors follow a random distribution and do not manifest in a systemic fashion, and thus do not impact the statistical results because they are diluted within the enormous size of the NIS dataset. Second, the predefined data limits of the NIS prevent us from ascertaining causal relationships and outcomes following hospitalization that may better explain observed effects in statistical regression models. Third, hospital charges within the NIS are not itemized in a manner that would permit isolation of the procedural cost versus hospitalization costs. However, in the context of this study, analysis of nonitemized charges may be more reflective of the true costs of hospitalization for each of the respective procedures. Fourth, although we provide the hospital charge data in Fig 1, caution is urged in using this metric, as hospital costs are a more reliable measurement of the normalized expenditure for each procedure.

Conclusions

Our findings indicate that typical costs for hospitalization for both carotid endarterectomy and carotid stent placement exceed payments under the revised CMS reimbursement system, regardless of outcome. Efforts to decrease hospitalization costs and/or increase payments will be necessary to make these carotid revascularization procedures economically viable in the long term.