If Italy are to claim a famous victory in Rome, the 30-year-old will have to be at his brilliant best, marshaling his side as he did in this fixture last year when Italy lost by seven points at Twickenham.

Who will win the Six Nations?

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Who will win the Six Nations?

Ireland

77.9%

England

18.6%

France

3.5%

Total votes: 86

On that occasion, Parisse's leadership had England hanging on for the win at the end of 80 minutes.

It will be up to Robshaw to impose his own impact on his team and galvanise his pack to dominate proceedings.

If England can win the forwards battle, they will win the game and will hope an Ireland loss may hand them the title.

Liam Williams vs. Stuart Hogg

David Rogers/Getty Images

Wales were dealt a huge blow towards the end of their 29-18 loss to England as Leigh Halfpenny walked off the field with an injured shoulder.

It has now been confirmed that he will be out for the rest of the season and will thus miss Wales' final Six Nations clash with Scotland.

Scarlets full-back Liam Williams is the likely replacement and he will have big shoes to fill as Halfpenny was one of few bright spots for Wales at Twickenham.