If the animal has been previously sensitized by exposure to an allergen (antigen) and produces IgE antibodies, then injection of the sensitizing antigens directly into the bloodstream can result in anaphylactic shock and related reactions (eg, hives, urticaria, facial-conjunctival edema). (merckvetmanual.com)

In dogs, the major organ affected by anaphylactic shock is the liver, and signs are associated with constriction of hepatic veins, which results in portal hypertension and visceral pooling of blood. (merckvetmanual.com)

Severe signs of anaphylactic reactions are manifested in the form of upper respiratory tract obstruction due to edema of the larynx (throat), epiglottis and surrounding tissues, and bronchoconstriction of the lower respiratory tract with the development of hypoxia. (hubpages.com)

It is necessary to immediately suspend the application of the drug (if that is the cause of anaphylactic reactions), to prevent further absorption of the drug, monitor vital functions (frequency and rhythm of the heart, blood pressure, heart rate, rhythm and depth of breathing), to ensure adequate oxygenation of the patient and to organize the rapid transport of patients the nearest emergency room or hospital. (hubpages.com)

This release of pre-formed mediators enables not only rapid anaphylactic reactions and allergic responses but also initiates recruitment of leukocytes to sites of pathogen invasion, activation of innate immune processes, and inflammatory responses (1). (wikipedia.org)

Papers on anaphylaxis, written in collaboration with Elmer Ernest Southard: The papers were published in the Journal of Medical Research (JMR) which was the publishing arm of the American Association of Pathologists and Bacteriologists: 1907: "On serum anaphylaxis in the guinea pig", Journal of Medical Research 16: 143-80. (wikipedia.org)

Incidence rate The American College of Allergy, Asthma and Immunology Epidemiology of Anaphylaxis Working group summary: overall frequency of episodes of anaphylaxis -between 30 and 950 cases per 100,000 persons per year. (slideplayer.com)

The charity actively campaigns to raise awareness of anaphylaxis with the general public and with the relevant authorities for better allergy care and treatments. (wikipedia.org)

The Anaphylaxis Campaign is a founder member of the National Allergy Strategy Group, a coalition of charities, professional organisations and industry, that seeks to improve health services for allergy sufferers in the UK. (wikipedia.org)

The Canadian Anaphylaxis Initiative (CAI) is a network of Canadian families, who are working with Members of Parliament to raise awareness in Ottawa regarding severe, life-threatening allergies (Anaphylaxis). (cai-allergies.ca)

The Anaphylaxis Campaign's ultimate aim is to create a safe environment for all people with allergies by working with and educating the food industry, schools, pre-schools, colleges, health professionals and other key audiences. (wikipedia.org)