The effects of mood on cognition are well-documented. However, would mood influence subsequent emotional reactions? The present research shows that prior moods interact with neuroticism to influence subsequent emotional experiences. Low-neuroticism individuals who initially felt negative subsequently experienced less negative emotions toward a slightly unpleasant task, relative to those who initially felt positive. Conversely, there were no mood effects on high-neuroticism individuals. This demonstrates that surprisingly, a prior negative, rather than positive, mood buffers low- but not high-neuroticism individuals from the effect of a subsequent unpleasant event on negative emotions. The possible mechanism underlying this effect—negative mood repair—is also discussed.