Using the application is as simple as checking the boxes for the applications you want to close and clicking the Close Tasks button or using the Ctrl+[ keyboard shortcut (configurable in the preferences). Once an application has been running but not used for more than 5 minutes, the boxes are checked by default, but you can exclude an application through the right-click menu—useful for applications like email that you might want to keep open all the time. I've found this application especially helpful for cleaning up the dozens of Windows Explorer panels that clutter my taskbar after a few hours of working—letting me close only the ones I haven't used in a while.