Okay, Mafia 101 is that you target anybody who makes hilariously wrong accusations. Sure, it's not quite random, but the minimal amount of information it gives is worth it for the high probability of giving strong misinformation.

Guess I'm getting lynched, or offed, then. As I love to make hilariously wrong accusations on the grounds of hilarity. Mind you, I usually wind up right which actually irks me some...being wrong and surprised is way more fun.

Well, I can't see logic behind Twilight's conclusion. Would I be an mafioso, my first move would be random, it's the best move, btw. If one of targets failed, I'd try it again cause chances of it being Nurse are high enough.

Hm, setup for a panel full of Rarity Investigates trenchcoat as she points at somebody else?
(And then seaweed-strewn PPOV version as the town decides to send her on a long walk off a short pier anyway?)
This is going to be fun.

Obviously Applejack would get taken out twice. After the first attempt, everypony would know she's innocent, so they'd listen to her more when deciding who to lynch, making it harder for the mafia to target innocent ponies. Also, since nopony would lynch her, they're more likely to lynch the mafia.

Not completely obvious, since the Nurse might consider the same thing and continue protecting her. If you keep throwing kills at a Nurse-protected player, that's one wasted kill every turn. And, it only further entrenches in peoples' minds that the player should be someone the citizens can rally behind.

I haven't read the night comics, but I feel like Twilight is Mafia here. Her talk about the eye dilation was a comment she wouldn't have actually noticed but she got a pass on because she's twilight and would notice that. She's also being overly analytical, almost like she's planned this entire thing. And knowing her, she would have planned how this all goes down.

I think Rarity is being framed and Twilight is playing 4-d chess.

That said, if Rarity is Mafia, then RD might be too, because Rarity defended her earlier.

If both detectives are still in play, why don't they advertise themselves as such, and share all the information they've gathered so far? It will make them prime targets for the Mafia, but this is Mafia match point already - the only way the town can win now is if they lynch a Mafia tonight (and even then it'll be tough).

Sure, they may or may not be believed, but it'll get the information out there, and I don't see much reason not to do it.