Course content

The course is an advanced course in theoretical and practical
genomics with focus on mammals. The course will provide information
that will allow the student to gain knowledge on methods and
technologies currently used to dissect, describe and characterise
complex genomes. Aspects of both research and application within
the field of genomics will be addressed.

Learning outcome

After completion of the course the student is expected to have:

Knowledge:

- Describe the architecture and components of an average mammalian
genome.
- Understand the possibilities of analyzing and characterizing
mammalian genomes.
- Understand qualitative and quantitative genetics with focus on
mammalian disease genetics.
- Describe the technologies and methods involved in genome projects
and the objectives of the different genome projects.
- Understand how comparative genomics can be used in the
characterization and annotation of genomes by transfering
genomic information from one species to another (comparative
genomics).
- Understand the regulation of gene expression at different
levels and how to study it. Focus on qPCR.

- Understand NGS technique
- Understand how mutations can cause inherited defects and
predisposition to disease such as cancer and the possibilities and
relevance of genetic testing.
- Understand innovation.

- Evaluation of strategies to dissect the genetics underlying
inherited traits in mammals.
- Evaluate the practical use of genetic testing.
- Think more innovative in relation to Biology-Biotechnology.

Recommended prerequisites

Basic knowledge in Genetics, Cell Biology and Molecular Biology

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Biology-Biotechnology students have priority over the other
educations.

Education

BSc Programme in Biology-Biotechnology
BSc Programme in Natural Sciences and IT
BSc Programme in Biology
MSc Programme in Animal-derived Foods (Food of Life)

Capacity

Language

Literature

Information about teaching material will be available
at Absalon before the course starts

Workload

Category

Hours

Lectures

43

Practical exercises

20

Theory exercises

12

E-Learning

3

Project work

10

Preparation

117,5

Exam

0,5

English

206,0

Exam

Type of assessment

Oral examination, 20 minutes

The 20 min. oral examination is based on the practical
laboratory work and on the curriculum.
You will draw two questions during the exam, one related to the
laboratory exercises and one related to the curriculum. There is no
time for preparation.
The student should show adequate knowledge and understanding of
both practical and curriculum related subjects in order to pass the
exam.

Weight: Oral examination 100 %.

Aid

Only certain aids allowed

The students can bring their own notes.

Marking scale

7-point grading scale

Criteria for exam assessment

To achieve the maximum grade of 12, the shall be able to:

Knowledge:

- Describe the architecture and components of an average mammalian
genome.
- Understand the possibilities of analysing and characterizing
mammalian genomes, and to understand qualitative and quantitative
genetics with focus on mammalian disease genetics.
- Describe the technologies and methods involved in genome
projects and the objectives of the different genome projects.
- Understand how comparative genomics can be used in the
characterisation of genomes by transfering genomic information from
one species to another.
- Understand the regulation of gene expression on different levels
and which techniques to apply to study it. Special
focus on NGS and qPCR.
- Understand how mutations can cause inherited defects and
predisposition to disease such as cancer and the possibilities and
relevance of genetic testing.

Skills:

- Knowledge on how to perfom basic and advanced methods in
molecular genetics.
- Knowledge on how to perfom DNA sequence analysis, simple sequence
assembly and annotation and detect sequence variation by using the
UCSC browser.
- Knowledge on how to perfom PCR.
- Knowledge on how to perfom quantitative PCR and analyse
expression profiles of genes in different tissues.

Competences:

- Evaluation of strategies to dissect the genetics underlying
inherited traits in mammals.
- Evaluate the practical use of genetic testing.

- Think more innovative in relation to
Biology-Biotechnology.

In order to complete the course with the grade 12, the
student should give an excellent performance during the exam
displaying a high level of command of all aspects of the drawn
practical and theoretical subjects.
The student should show a exhaustive
comprehension of all the matters/principles asked during the
exam with no or only few minor mistakes/weaknesses, and
he/she should be able to integrate knowledge from different
subjects and areas when relevant.

Censorship form

No external censorship

2 examinators

Exam period

Week 25. The exact days will be anounced at
the beginning of the course.

Re-exam

An approved written report about the practicals is prerequisite
for access to oral re-examination.