Wang Bi's most important works are commentaries on Laozi's Dao De Jing and the I Ching. The text of the Dao De Jing that appeared with his commentary was widely considered the best copy of his work until the discovery of the Mawangdui texts in 1973. He was a scholar of xuanxue.

Wang served as a minor bureaucrat in the state of Cao Wei during the Three Kingdoms period. He was married with a daughter when he died of sickness at the age of 23.