About The Cover

ONLINE COVER Slimming Down the Liver. The image shows fat accumulation in the liver of a mouse fed a high-fat Western-style diet as a model of nonalcoholic fatty liver disease. This condition is becoming increasingly prevalent with the rising incidence of obesity, and treatment options are very limited. In this issue, Rao et al. demonstrate that a drug can decrease fat accumulation in the liver and associated complications in mouse models by blocking the uptake of bile acids in the intestine. [CREDIT: RAO ET AL./SCIENCE TRANSLATIONAL MEDICINE]