Through a microarray differential expression analysis, including all sequences mapping inside STR1, we discovered the gene encoding the mitochondrial protein Ndufc2 (a subunit of the OXPHOS complex I, encoded by nuclear DNA) as a sequence significantly downregulated by high salt diet only in the brain of SHRSP as compared to the SHRSR [13].

sup][6],[7] Mitochondrial OXPHOS defects resulting in the reduction of adenosine triphosphate (ATP) generation and longstanding increase of ROS production may be responsible for the pathogenesis of hypertension, cardiac contractile dysfunction and, subsequently, heart failure and death.

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