From its 17th Century founding to the Revolutionary War to the Civil War, Charleston, SC has had a lasting effect on the world. This serialized anthology series follows the epic tales of historical figures whose lives intertwine through this storied city's past, starting with its first citizen, Dr. Henry Woodward.

In 1665 , the new owners of Carolina, the Lords Proprietors, commission Sir John Yeamans as Governor and task him with founding a colony at Port Royal Sound. Yeamans sends naval surgeon Doctor Henry Woodward with Captain Robert Sanford on the expedition which leaves the doctor in a precarious place.