Title (fr)

Publication

Application

Priority

US 9914122 W 19990701

US 10936598 A 19980702

Abstract (en)

[origin: WO0001689A1] A process for producing compounds of formula (1.0) is disclosed. The compound of formula (1.0) is produced by: (1) separating the atropisomers of (2.0) to obtain the atropisomers (2.0A) and (2.0B); (2) heating the atropisomer of formula (2.0B) at a suitable temperature in a suitable solvent to obtain a mixture of atropisomers of formulas (2.0A) and (2.0B); (3) separating the atropisomers of formulas (2.0A) and (2.0B) of step (2); and (4) reducing the atropisomer of formula (2.0A) to obtain a compound of formula (1.0). Preferably, R<1> is Br, R<2> is Cl and R<3> is Br. Also disclosed is the (+)-atropisomer of formula (2.0) wherein R<1> is Br, R<2> is Cl and R<3> is Br.