Starting out as a manga by Kazuki Takahashi, Yu-Gi-Oh! tells the story of Yugi Mutou, a put-upon teenager who is pulled into a world of intrigue and high-stakes gaming after solving the mysterious and ancient Millennium Puzzle. The puzzle, an artifact from ancient Egypt, grants Yugi a mysterious alter ego, who spends much of the early series facing evildoers who threaten his friends in "Shadow Games," where mystic forces punish the wicked if they lose.

Slowly, the focus of the story turned towards the trading card game Duel Monsters, which was eventually revealed to be based on an ancient Egyptian game played by the previous owners of the Millennium Items. From then on, Yugi and his friends, find themselves facing bad guys seeking to use the power of Yugi's Millennium Puzzle for their own nefarious purposes, and always in games of Duel Monsters.

Yu-Gi-Oh! ZEXAL: The manga that came shortly before the third anime series. It follows mostly the same story, but with several different characters.

Yu-Gi-Oh! D Team ZEXAL: A Lighter and Softer manga adaptation of Zexal, intended to taught younger audience to play the card game.

Yu-Gi-Oh! ARC-V: The fourth anime spin-off, starring Yuma Sakaki. Notable for including all advanced Special Summoning method to the plot instead of just focusing on the newest one that the time, Pendulum Summon.

Yu-Gi-Oh! ARC-V: The Strongest Duelist Yuya: A lighter manga series for younger demographics, in the same vein as D Team ZEXAL.

Yu-Gi-Oh! ARC-V: Another manga adaptation of ARC-V. Just like the other "main" manga adaptations, it features a different plot than the anime, with most of the same characters.

Yu-Gi-Oh! VRAINS: The fifth anime spin-off, it features Yusaku Fujiki surfing with the winds of virtual reality.

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