In Tales of Monkey Island, hapless pirate Guybrush Threepwood embarks on a quest to find the voodoo exfoliating artifact, La Esponja Grande, after accidentally releasing the pox of LeChuck on the Caribbean's unsuspecting population (and his wife, Elaine). Along the way, Guybrush fends off a relentless pirate hunter, matches wits with a malicious marquis, overcomes fearsome foes with sabers at sea, and is nearly digested by a giant manatee while hunting down the pox-eliminating sponge. Rise of the Pirate God picks up after the cataclysmic events from the final scenes of chapter 4, which left audiences reeling after a resurgent LeChuck deals a mortal blow to the heroic mighty pirate.