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4 comments:

Very pleased to see coverage of tropical diseases and the neuropsych outcomes, you may be interested to know we're just writing up some research from my student's PhD on outcomes for Ugandan children of treatment of maternal worms.

I have in mind to write a first-person piece about doing research in this area, though a large pile of admin is calling my name first!

I wonder if you are familiar with the hygiene hypothesis, or the use of hookworms as a treatment for Crohn's Disease?

I would argue that there are many occasions when an infestation of hookworm can be beneficial to patients with Crohn's - and a range of other auto-immune diseases.

Much research has already been done by Prof Pritchard at Nottingham, but more still needs to be done. We need to discover what a therapeutic dose is - 15 worms? 25 worms? More? less?

I for one would love to have the chance to try hookworm treatment - it has to be a more benign option than weekly injections of methotrexate, steroid treatment or infusions of infliximab.

I'm sure you mean well, but your article in the Guardian simply adds to the general noise (and hysteria) that slows down research into hookworm therapy.

You write about "...a parasitic worm infection..." as if it were a singular entity, without being specific about actual levels of infestation - a very lazy approach, if I may say. An infestation of 10 worms will clearly affect the host less than an infestation of 100… or 500… or 5,000…

What causes Crohn's is not understood at all - however in the developed West, it, and other auto immune diseases, are at epidemic levels.

In the third world Crohn's is virtually unknown - especially in countries that have high incidence of hookworm infestation.

Perhaps we in the West have eradicated too much of the floor and fauna of the gut, and maybe, just maybe hookworms are our friends?

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