A vehicle with 5 LN rounded a corner on RT BEAR and approached OUTLAW 1 moving at a high rate of speed. Hand and arm signals were made and the vehicle slowed to a crawl, still approaching. The vehicle began to accelerate and hand and arm signals were made again but the vehicle did not stop. Outlaw 1 gunner fired .50 cal rounds from M2 at the vehicle when the vehicle was 10-15m from FF. 4x LN KIA 1x LN WIA. 1x WIA were transported to a Mirwais hospital in Kandahar City by host nation ambulance. Vehicle was destroyed. Meets SIR, CCIR criteria.