Travasol

DRUG DESCRIPTION

10% Travasol® (Amino Acid) Injection is a sterile, nonpyrogenic hypertonic solution of essential and nonessential amino acids in a Pharmacy Bulk Package. A Pharmacy Bulk Package is a container of a sterile preparation for parenteral use that contains many single doses. The contents are intended for use in a pharmacy admixture program and are restricted to the preparation of admixtures for intravenous infusion.

The Viaflex® plastic container is fabricated from a specially formulated polyvinyl chloride (PL 146® Plastic). Exposure to temperatures above 25ºC/77ºF during transport and storage will lead to minor losses in moisture content. Higher temperatures lead to greater losses. It is unlikely that these minor losses will lead to clinically significant changes within the expiration period. The amount of water that can permeate from inside the container into the overwrap is insufficient to affect the solution significantly. Solutions in contact with the plastic container can leach out certain of its chemical components in very small amounts within the expiration period, e.g., di-2-ethylhexyl phthalate (DEHP), up to 5 parts per million; however, the safety of the plastic has been confirmed in tests in animals according to USP biological test for plastic containers as well as by tissue culture toxicity studies.

Amino acids

10 g

Total nitrogen

1.65 g

pH

6.0 (5.0 to 7.0)

(pH adjusted with glacial acetic acid and may have been adjusted
with sodium hydroxide.)

Essential Amino Acids

Leucine - C6H13NO2

730 mg

Isoleucine - C6H13NO2

600 mg

Lysine (added as the hydrochloride salt) - C6H14N2O2

580 mg

Valine - C5H11NO2

580 mg

Phenylalanine - C9H11NO2

560 mg

Histidine - C6H9N3O2

480 mg

Threonine - C4H9NO3

420 mg

Methionine - C5H11NO2S

400 mg

Tryptophan - C11H12N2O2

180 mg

Nonessential Amino Acids

Alanine - C3H7NO2

2.07 g

Arginine - C6H14N4O2

1.15 g

Glycine - C2H5NO2

1.03 g

Proline - C5H9NO2

680 mg

Serine - C3H7NO3

500 mg

Tyrosine - C9H11NO3

40 mg

Anion profiles per liter*

Acetate†

88 mEq

Chloride‡

40 mEq

Osmolarity (Calc.)

998 mOsmol/L

*Balanced by ions from amino acids. †derived from pH adjustment with glacial acetic acid‡contributed by the lysine hydrochloride

Last reviewed on RxList: 5/5/2009
This monograph has been modified to include the generic and brand name in many instances.