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Abstract

Purpose: We have previously demonstrated that adventitial inflammation plays an important role in the pathogenesis of coronary vasospasm in porcine models. The adventitia harbors a variety of components with potent modulation of vascular tone, including vasa vasorum (VV) and sympathetic nerve fibers (SNFs). We tested our hypothesis that adventitial VV and SNFs are involved in the pathogenesis of coronary hyperconstricting responses after DES implantation in pigs in vivo.

Results: Coronary vasoconstricting responses to serotonin were significantly enhanced at the edges of the SES and the EES sites, associated with increased adventitial densities of VV (vWF) and SNFs (TH) as compared with the control sites and the BES edges (all P<0.05) (Figure). There were highly significant correlations between SNFs and VV (R=0.64, P<0.0001) and between SNFs and vasoconstricting responses (R=0.47, P<0.005).

Conclusions: These results indicate that adventitial VV and SNFs may be involved in the pathogenesis of DES-induced coronary hyperconstricting responses, which are less pronounced with new generation BES.