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Evaluation of Protein A resin lifetime during extensive use (overloading) in continuous chromatography mode

GE Healthcare Life Sciences,

In recent years, continuous chromatography has emerged as an alternative to batch operations to improve productivity or increase resin capacity utilization of chromatography purification processes. This application note compares the performance of MabSelect SuRe pcc resin designed for continuous capture of mAbs, with the conventional high-capacity Protein A resin MabSelect SuRe LX. The study was designed to investigate resin lifetime when operated in continuous mode.