In total, the Diabetes Clinical Research Center is currently following more 1000 research participants in our studies conducted at Mass General. Click on the page links for more information about these studies.

Current Research Clinical Trials

A1c-Derived Average Glucose Study: International study to determine whether A1c values can be translated into estimated average glucose values to aid management;

Closed loop pump therapy of type 1 diabetes: Development of an artificial pancreas for the treatment of type 1 diabetes;

Comparative study of insulin therapy of type 2 diabetes;

Continuous glucose monitoring (CGM) in the Intensive Care Unit: Examination of different CGM devices to determine whether they can be used to guide therapy in the intensive care unit setting;

TODAY: Study of the best means to treat type 2 diabetes in children and adolescents.

Notable Past Research Clinical Trials

Diabetes Control and Complications Trial (DCCT): Hailed as the most important studies in diabetes since the discovery of insulin, the DCCT demonstrated the primacy of intensive metabolic control in preventing the development of complications in Type 1 diabetes and established Mass General as one of the premier centers for the study of type 1 diabetes and its complications

Implantable Pump Project: an international study lead by MGH investigators that established the utility of an implantable pump (first developed by MGH investigators, in the treatment of type 1 diabetes.

Whole organ transplantation: the first progrsm in New England to estasblish a high rate of success and safety of simultaneous kidney/pancreas transplantation.

Islet transplantation: the first successful isolation and purification of human islets in New England with subsequent transplantation

Established a 75% success rate in normalizing blood sugar control in type 1 diabetes.

Other Clinical Research

In addition to the clinical trial studies highlighted above, the MGH Diabetes Unit performs studies of human physiology and numerous epidemiologic studies in collaboration with the Framingham Heart Study, Baltimore Longitudinal Study of Aging, and Nurses and Physicians Health Studies that have explored the risk factors of diabetes and its complications and in particular the relationship between glycemia and heart disease. Other areas of active research includes quality improvement and health care policy research.

PublicationsView recent publications from the Diabetes Clinical and Translational Research Center. Some full text articles may require a subscription.