Background and Objective: Nurses are among the key people who have the most relationship with patients. Effective communication skills in nurses lead to satisfaction of patients with nursing services, stress reduction in patients and speeding up their recovery. Therefore, the current study aims to determine the effect of educational intervention based on BASNEF model on communication skills of nurses with patients in hospitals affiliated to Tehran University of Medical Sciences.Methods:This is a quasi-experimental study with a control group conducted on 96 nurses working in two hospitals affiliated to Tehran University of Medical Sciences in 2016. The participants were randomly selected from 17 hospitals of Tehran University of Medical Sciences. The data-gathering tools were a demographic questionnaire and a researcher-made questionnaire based on the structures of the BASNEF model. Educational intervention was performed based on the results of the pre-test in the intervention group in 3 sessions of 45 minutes. The collected data were analyzed using SPSS 18, statistical tests, Fisher exact test, independent t-test, ANOVA, and paired t-test.Results: The results of this study showed that the mean score of knowledge, as well as the structures of the BASNEF model were significantly different from that of the control group’s after educational intervention (P<0.05), which confirms the effect of education on the basis of the BASNEF model.Conclusion: According to the results of this research, education based on the BASNEF model leads to the development of communication skills with the patient in nurses. Therefore, the researchers recommend education based on this educational model.