ActiTarg-N library of 1040 analogs is selected from a compound pool with cumulative structural features that are inherent across some 90 known nuclear receptors ligands.

Nuclear Receptors ligands analogs compound pool started with “de-fragmented” active molecules. TimTec stock was scanned to identify molecules with the same fragments, which re-assembled themselves in new chemical possibilities. Additional computational manipulations drew in more compounds with overall structural similarity to known nuclear receptors ligands. Further filtering ensured structural diversity in the final selection.

Compounds are available for cherry-picking and/or as an entire collection of 1040 compounds in 96, 384-well plates and in vials.Contact us for structural info, formatting options and pricing.

Nuclear Receptors target pool:

ER , estrogen receptor and estrogen related receptor

AR, androgen receptor

GRR, glucocorticoid receptor

RAR, retinoic acid receptor

THR, thyroid hormone receptor

VDR, vitamin D receptor

FXR, Farnesoid X Receptor

PPARa/y, Peroxisome proliferator-activated receptors

LXR, liver X receptor

CCR5, C-C chemokine receptor type 5

MRR, mineralocorticoid

PR, progesterone receptor

CAR, Constitutive androstane receptor

and others

About nuclear receptors

Nuclear receptors are inside-cell proteins that regulate gene transcription and affect wide range of biological functions throughout organism normal and pathological development. These are the superfamily of 48 structurally related transcription factors that can be regulated by small molecules.