BACKGROUND
Preserved energy metabolism is essential for myocardial viability and the creatine kinase reaction is central to energy production and reserve. Although the appearance of myocardial creatine kinase enzyme in the blood is widely used to diagnose cardiac necrosis, there are no non-invasive ways to measure local creatine concentrations in the healthy and diseased human heart.
METHODS
We measured total myocardial creatine by spatially-localised, water-suppressed hydrogen magnetic… CONTINUE READING