Check the appropriate box to
designate the rule pursuant to which this Schedule is filed:

☐ Rule 13d-1(b)

☒ Rule 13d-1(c)

☐
Rule 13d-1(d)

*

The remainder of this cover page shall be filled out for a reporting persons initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information
which would alter the disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be
deemed to be filed for the purpose of Section 18 of the Securities Exchange Act of 1934 (Act) or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act
(however, see the Notes).

1.

Name of Reporting
Person:

Novo Holdings A/S (formerly known as Novo A/S)

2.

Check the Appropriate Box if a Member of Group
(See Instructions):

(a) ☐ (b) ☐

3.

SEC Use Only:

4.

Citizenship or Place of Organization:

Denmark

Number of

Shares

Beneficially

Owned By

Each

Reporting

Person

With:

5.

Sole Voting Power:

2,924,822

6.

Shared Voting Power:

0

7.

Sole Dispositive Power:

2,924,822

8.

Shared Dispositive Power:

0

9.

Aggregate Amount
Beneficially Owned by Each Reporting Person:

2,924,822

10.

Check if the Aggregate Amount in Row (9) Excludes
Certain Shares: ☐

11.

Percent of Class Represented By Amount In Row
(9):

8.0%(1)

12.

Type of Reporting Person:

CO

(1)

Based upon 36,691,490 Ordinary Shares outstanding as of November 3, 2017, as reported in the Issuers Form 10-Q filed with the Securities and Exchange Commission (the
SEC) on November 9, 2017.

2

This Amendment No. 2 amends the Schedule 13G/A filed with the SEC on February 8, 2017.

Item 1.

(a) Name of Issuer:

Nabriva Therapeutics PLC

(b)

Address of Issuers Principal Executive Offices:

Leberstrasse 20

1110 Vienna, Austria

Item 2.

(a) Name of Person Filing:

Novo Holdings A/S, a Danish limited
liability company, is wholly owned by Novo Nordisk Fonden (the Foundation), a Danish commercial foundation. Novo A/S changed its name to Novo Holdings A/S on June 23, 2017. Novo Holdings A/S is the holding company in the
group of Novo companies (currently comprised of Novo Nordisk A/S, Novozymes A/S and NNIT A/S) and is responsible for managing the Foundations assets, including its financial assets. Based on the governance structure of Novo Holdings A/S and
the Foundation, the Foundation is not deemed to have any beneficial ownership of the securities of the Issuer held by Novo Holdings A/S.

(b)

Address or Principal Business Office or, if none, Residence:

Tuborg Havnevej 19

2900 Hellerup, Denmark

(c)

Citizenship or Place of Organization:

Novo Holdings
A/S: Denmark

(d)

Title of Class of Securities:

Ordinary Shares

(e)

CUSIP Number:

62957M104

Item 3.

If this statement is filed pursuant to §§240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:

Not applicable.

3

Item 4.

Ownership:

Provide the following information regarding the aggregate number and percentage of the class
of securities of the issuer identified in Item 1.

(a)

Amount beneficially owned:

2,924,822

(1)

(b)

Percent of class:

8.0%

(2)

(c)

Number of shares as to which such person has:

(i) Sole power to vote or to direct the vote:

2,924,822

(1)

(ii) Shared power to vote or to direct the vote:

0

(iii) Sole power to dispose or to direct the disposition of:

2,924,822

(1)

(iv) Shared power to dispose or to direct the disposition of:

0

(1)

Novo Holdings A/S, through its Board of Directors (the Novo Board), has the sole power to vote and dispose of the shares (or ADS) beneficially owned by Novo Holdings A/S (the Novo
Shares). The Novo Board, currently comprised of Sten Scheibye, Francis Michael Cyprian Cuss, Goran Ando, Jean-Luc Butel, Jeppe Christiansen, Steen Riisgaard, Per Wold-Olsen and Lars Rebien Sorensen,
may exercise voting and dispositive control over the Novo Shares only with the support of a majority of the Novo Board. As such, no individual member of the Novo Board is deemed to hold any beneficial ownership or reportable pecuniary interest in
the Novo Shares.

(2)

Based upon 36,691,490 Ordinary Shares outstanding as of November 3, 2017, as reported in the Issuers Form 10-Q filed with the SEC on November 9, 2017.

Item 5.

Ownership of Five Percent or Less of a Class:

Not applicable.

Item 6.

Ownership of More Than Five Percent on Behalf of Another Person:

Not applicable.

Item 7.

Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company or Control Person:

Not applicable.

Item 8.

Identification and Classification of Members of the Group:

Not applicable.

Item 9.

Notice of Dissolution of Group:

Not applicable.

4

Item 10.

Certifications:

By signing below I certify that, to the best of my knowledge and
belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as
a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under § 240.14a-11.

5

SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true,
complete and correct.