Muscle strength according to Medical Research Council Scales (MRC) and quantitative strength measurement evaluated by hand-held dynamometry (Citec, Groningen, The Netherlands)in the same muscle groups.

Dysferlin protein expression levels change from baseline over 5 days assessed by repeated biopsies and blood draws in skeletal muscle and in blood monocytes following administration of a single dose of Bortezomib.

3

All

18 Years and older (Adult, Senior)

NCT01863004

DYSF001A12011DR1148

Dysferlin

December 2012

September 15, 2017

September 15, 2017

May 27, 2013

September 21, 2017

Neuromuskuläres Zentrum, Universitätsspital BaselBasel, Switzerland

† Study has passed its completion date and status has not been verified in more than two years.