ProjectSAM’s anti-marijuana priorities include emphasizing the “lifelongstigma” of pot-related arrests, the prospect of “Big Marijuana”marketing it to children, the industry being taken over by Big Tobacco,and seeking federal research on pharmaceuticalized medical marijuanaproducts.

Unlike Sabet, I have spent more than a decade training in the relevant disciplines he attempts to speak for. I’ve earned degrees in medicine and medical social scientific fields, not social policy like Sabet, and I feel the need to debunk his "moral entrepreneurship" that demonizes marijuana use and ignores scientific research that contradicts his drug warrior claims.

What follows are five claims from his list of talking points—fictions—followed by the facts.

However one medicinal agent is delivered into the body should have no bearing whatsoever on how another medicinal agent should or should not be given. To believe so shows a fundamental lack of understanding of the variation of medicines and modes of delivery in modern clinical practice. To allow medicinal use of cannabis-marijuana does not mean that one would only be presented with the option of smoking it to receive its therapeutic effects. Many other modes of delivery: oral, topical, sublingual, vaporized, etc. are available.

Moreover, the harms of cannabis smoking are nowhere near the harms of tobacco smoke. All large-scale, long-term epidemiological studies conducted to date have not shown any links to COPD or lung cancer. In fact, cancer-protective effects have been demonstrated in at least two studies. Opium is consumed orally in medicine today in the tincture form of paregoric, used across the United States in hospitals and clinics for refractory diarrhea.

Adequate and well-controlled studies proving the medical efficacy of cannabis exist, but are ignored by marijuana schedulers in the Department of Health and Human Services, under which the FDA resides. Large, multicenter, randomized, double-blind, placebo-controlled studies involving hundreds of patients in America and abroad that are in some cases a year in duration have been published in U.S. National Library of Medicine indexed journals showing that marijuana, orally administered in extract form, can treat intractable pain in cancer and improve mobility and symptom control in multiple sclerosis.

This assertion is based on a reference to a research study from New Zealand published in the Proceedings of the National Academies of Science in August 2012 that grossly mischaracterizes its results, and did not in fact establish this causal link.

In this research, there was no breakdown of frequency or amount of cannabis used to see if there was any "dose dependency" to the effects—an important item in association studies. The study’s cannabis exposure data was strictly based on self-report, even though other data, such as the subjects’ reported cognitive performances, were corroborated by statements from close contacts. There was only consideration of alcohol dependence, not binge drinking patterns, which have also been shown to be neurotoxic, and if occurring, would confound results. Schizophrenia was considered as a confounding factor, but other mental illnesses such as major depression, anxiety, PTSD or traumatic brain injuries, such as concussions, all of which can reduce performance on neurocognitive tests, were not factored in.

In other words, the "pot makes you stupider" proof was not there. There was no neuroimaging or physiological/neurochemical/anatomical correlates presented. A subsequent study published in the same journal with the same dataset concluded that all the variation in cognitive effects could be explained just as easily by socioeconomic variables rather than cannabis use, which cast significant doubt on the robustness of the initial study.

Pioneering scientists and doctors such as Carl Sagan, Lester Grinspoon, Richard Feynman, Stephen Jay Gould, Andrew Weil, Oliver Sacks, and others have stated that cannabis use improved the quality of their intellectual work. This aspect of cannabis use is entirely ignored by Sabet and his colleagues. Finally, Dutch senior high school students rank number one in math and number two in science globally, despite the country having a de facto legal marijuana market for over 30 years.

Aside from the fact that Sabet varies his figures based on which media outlet he is communicating to, it is patently false to claim that marijuana-cannabis and the forms it was ingested in were somehow so different 50 years ago. Cannabis resin, produced by its flowers, has always been concentrated in solutions that were consumed orally. So it is false to claim that the cannabis available today is somehow so different than what it was in the past.

If there are higher potency forms of herbal cannabis available, based on THC content, it’s due to the pressures produced by prohibition and the lack of legal regulation. And it can be a good thing, if a higher THC percentage is present, as a consumer would need to consume less to achieve a desired effect. Additionally, there are other cannabinioids and terpeniods whose concentration can be varied to produce a variety of effects.

While people can certainly have unpleasant reactions from consuming too much THC-rich cannabis, the best way to address this is labeling and consumer education, not blackmarket-generating prohibition and contrabanding.

Sabet has made this outrageous statement by citing Johns Hopkins epidemiologist J.C. Anthony, as well as federal drug abuse research summaries produced by the National Institute on Drug Abuse (NIDA), whose director, Nora Volkow, has made this same claim.

Both sources, however, rely on psychiatric diagnostic manuals widely criticized in peer-reviewed literature (see here and here) for gross over-pathologization of substance-related problems. Eager to diagnose, these studies ignore the impact that aggressive policing of cannabis has on users. The illegality of marijuana not only affects what subjects will be willing to disclose to researchers, but the stress of engaging in behavior that can lead to "social death"—suspension, arrest, loss of job, benefits, etc.—may be more psychologically trying than the drug itself.

The research supporting the claim is also based on faulty math. While the "1 out of 6" statistic does not appear anywhere in the text, figures or tables of the references (2002, 1994), the only way to come to this number is by manipulating numbers. The study's authors attempt to measure the “Cumulative Probability for Meeting Criteria for [Marijuana] Dependence” by a certain age does not follow users over time, and thus represents a survey-based snapshot of their lives in which they recollect their past use. This data, collected from 3,940 total users sampled of whom 354 were classified as dependent, allows for the inference that, by age 18, 5.61% or "1 in 17" marijuana users are at risk for dependence. It does not, however, allow for an analyst to add together dependence risk percentages from ages 10, 15, 16, 17 and 18 , to get 14.5% or "1 in 6." If the same math were applied to all ages reported, you would end up with 162.24%.

The proposals that Sabet pushes, while dressed in science, are essentially moral judgments. This is why there is no attempt to take seriously the large body of evidence showing the beneficial impacts of cannabis use or regulated cannabis markets on human health and social well-being. His major thrust is moral entrepreneurship: to popularize negative associations such as "threatening" and "culturally foreign" with cross-cultural, millennia-old, common human-cannabis relationship behaviors such as cultivation, consumption and trade.

Sabet and his team, many of whom are specialists in addiction or are recovering addicts, such as SAM’s chairman, former congressman Patrick J. Kennedy, are not interested in this evidence. They continue with a soundbite debate society approach, which neglects the fact that millions of lives globally are ruined annually due to an unevenly applied penalty system ranging from arrest to the death penalty.

Concerning "the use of marijuana, LSD and other psychedelic products," we have already informed the National Spiritual Assembly of the United States that Bahá'ís should not use...substances, except when prescribed for medical treatment.

Sabet may seek to seem reasonable by saying that there is benefit to "components” of cannabis, but despite his wishes, we must not allow it to remain tightly in the hands of the pharmaceutical sector but rather available as widely as possible like other herbal medicines.

Cannabis, a commonwealth plant that evolved 34 million years ago, which has a myriad of benefits as medicine, food, fiber, fuel, relaxant, etc. should not belong only to a wealthy, well-connected elite. Given Sabet’s prior political track record—campaigning against drugs and other "immoral" indignities since his U.C. Berkeley days—it is not surprising that he has chosen to serve the interests of the few over the many.

Fortunately, the pushback on the talking points epitomized by Project SAM is forcing Sabet to retreat from his most strident comments. His Huffingtonpost blog recently noted that “folks” who are studying how to “do legalization best” have come up with some “laudable proposals.”

But marijuana proponents should not be fooled. Kevin Sabet has built a career being a drug warrior and conservative contrarian. And if the bio on his personal website tells us anything, it is that right-wingers like Sabet know how to reinvent themselves to perpetuate the 1960s culture war.

Sunil Kumar Aggarwal is a senior resident physician at a large academic medical center in New York City. He is the author of the review article "Cannabinergic Pain Medicine: A Concise Clinical Primer and Survey of Randomized Controlled Trial Results" featured on the the cover of the February 2013 issue of The Clinical Journal of Pain.

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In 2011 the 1961 UN Single Convention on drugs will be in place for 50 years. In 2012 the international drug control system will exist 100 years since the International Opium Convention was signed in 1912 in The Hague. Does it still serve its purpose or is a reform of the UN Drug Conventions needed? This site provides critical background.