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Abstract

To the editor: The letter from Drs. Moulding, Iseman, and Sbarbaro (Ann Intern Med 85:398-399, 1976) contains some misinformation concerning Public Health Service data on isoniazid-related hepatotoxicity. Using criteria established by a panel of experts in hepatic disease, the Public Health Service study showed that the incidence of hepatotoxicity was 2.3% per year for persons 50 to 64 years of age and 0.8% for persons over 64 years of age (1). Therefore, the statement ". . . the incidence of hepatotoxicity . . . for persons above 50 years, 2.3% per year" is incorrect. The rate for all persons 50