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Abstract

Macroglobulinemia was first described as an entity by Waldenström in 1948,1 in discussing six patients seen by him in Upsala, Sweden. By means of ultracentrifugation of the patients' sera he was able to demonstrate the presence of a fraction in the serum proteins—presumably globulins—with molecular weights near 1,000,000, in contrast to the highest normal globulin molecular weights of 150,000.

Other cases have been reported sporadically from Europe. In 1950 Tischendorf and Hartmann2 reported one case, Bichel, Bing and Harboe3 another. Schaub added three cases in 19524 and one in 1953.6 Habich5 in 1953 studied the sero-immunologic properties of macroglobulins and