Previous GeneCards Identifiers for ERBB2IP Gene

Summaries for ERBB2IP Gene

Entrez Gene Summary for ERBB2IP Gene

This gene is a member of the leucine-rich repeat and PDZ domain (LAP) family. The encoded protein contains 17 leucine-rich repeats and one PDZ domain. It binds to the unphosphorylated form of the ERBB2 protein and regulates ERBB2 function and localization. It has also been shown to affect the Ras signaling pathway by disrupting Ras-Raf interaction. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

GeneCards Summary for ERBB2IP Gene

ERBB2IP (Erbb2 Interacting Protein) is a Protein Coding gene.
Among its related pathways are Signaling by FGFR and Signaling by GPCR.
GO annotations related to this gene include structural constituent of cytoskeleton and ErbB-2 class receptor binding.
An important paralog of this gene is MFHAS1.

UniProtKB/Swiss-Prot for ERBB2IP Gene

Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated Tyr-1248 of receptor ERBB2, it may contribute to stabilize this unphosphorylated state (PubMed:16203728). Inhibits NOD2-dependent NF-kappa-B signaling and proinflammatory cytokine secretion (PubMed:16203728).

Protein details for ERBB2IP Gene (UniProtKB/Swiss-Prot)

Protein attributes for ERBB2IP Gene

Size:

1412 amino acids

Molecular mass:

158298 Da

Quaternary structure:

Interacts with ERBB2, BPAG1 and ITGB4 (PubMed:10878805, PubMed:11375975, PubMed:12444095). May favor the localization of ERBB2, by restricting its presence to the basolateral membrane of epithelial cells. Also found to interact with ARVCF and delta catenin (PubMed:11821434). Interacts (via C-terminus) with DST Isoform 3 (via N-terminus) (PubMed:11375975). Interacts with NOD2 (via CARD domain) (PubMed:16203728).

Flow Cytometry Products

Function for ERBB2IP Gene

Products:

Molecular function for ERBB2IP Gene

UniProtKB/Swiss-Prot Function: Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated Tyr-1248 of receptor ERBB2, it may contribute to stabilize this unphosphorylated state (PubMed:16203728). Inhibits NOD2-dependent NF-kappa-B signaling and proinflammatory cytokine secretion (PubMed:16203728).

Localization for ERBB2IP Gene

Subcellular locations from UniProtKB/Swiss-Prot for ERBB2IP Gene

Cell junction, hemidesmosome. Nucleus membrane. Basolateral cell membrane. Note=Found in hemidesmosomes, which are cell-substrate adhesion complexes in stratified epithelia. In transfected cells, either diffusely distributed over the cytoplasm or concentrated at the basolateral membrane. Colocalizes with the adrenergic receptors, ADREN1A and ADREN1B, at the nuclear membrane of cardiac myocytes (By similarity). {ECO:0000250}.