There is just enough space in all of the Friend Areas to have one of every 386 Pokémon from the first three generations, along with all forms of Unown.

Some Friend Areas can be earned by completing certain missions, while others must be bought in Pokémon Square from Wigglytuff. There are also some that are obtained by recruiting a specific Pokémon, usually a legendary Pokémon. When the game starts, the player and their partner will have access to two Friend Areas, those being the ones said Pokémon fit into. The first time the player talks to Wigglytuff, they are given Mist-Rise Forest and the Wild Plains Friend Area. Magnemite also requests that they be given the Power Plant area so it can join the rescue team.