Successfully complete the game on any difficulty to unlock the "New Game +" option at the main menu. New Game + mode allows you to start a new playthrough on any available difficulty and retain all previously obtained upgrades and evolution levels from your previous playthrough.

Insane mode

Successfully complete the game on any difficulty to unlock the Insane difficulty.

Upgrade locations

Search the indicated locations and complete the listed tasks to unlock upgrades. You must consume the DNA of each target to get the upgrade. If you accidentally kill any of these targets, they will randomly respawn. It is recommended you first complete all main story and BlackNet missions. Then, fly over the streets with a helicopter to locate the targets for any remaining upgrades. Move from island to island until you have found all the upgrades. You can also enter the listed coordinates (longitude, latitude) into the in-game map to find the indicated target more easily. Note: Some of these targets will respawn at different locations if they were killed. Thus, you may not find them at the specified locations.

Location: Red Zone, Midtown - Locate the Brawler on the ground or rooftop of the arena, then consume it to get the upgrade.

Upgrade #4

Coordinates: 652, 278

Location: Red Zone, Midtown - Successfully complete the "Blackwatch" mission, then locate the Brawler on the street, and consume it to get the upgrade.

Pack Leader

Upgrade #1

Coordinates: 477, 255

Location: Red Zone, Midtown - Locate the Brawler on the ground floor or rooftop of the building, then consume it to get the upgrade.

Upgrade #2

Coordinates: 646, 239

Location: Red Zone, Midtown - Locate the Brawler on the streets, by the lair, then consume it to get the upgrade.

Upgrade #3

Coordinates: 613, 431

Location: Red Zone, Chinatown - Successfully complete the "Last Resort" mission, then locate the Brawler on the street, and consume it to get the upgrade.

Upgrade #4

Coordinates: 568, 132

Location: Red Zone, Times Square - Successfully complete the "Last Resort" mission, then locate the Brawler on the street, and consume it to get the upgrade.

Shield

Upgrade #1

Location: Defeat Roland in the "A Nest Of Vipers" mission to unlock it.

Lair locations

Search the indicated locations to find all nine lairs. A biohazard symbol will appear near each lair. Enter each lair, and kill all the marked targets inside. You can keep track of your progress through the in-game collectibles map, which will show you how many lairs are in each area and how many you have found. If you find it difficult to locate any lair, keep flying close to streets, and you should find it. You can also enter the listed coordinates (longitude, latitude) into the in-game map to find the indicated lair more easily.

Lair 1

Yellow Zone - Linden Park

Coordinates: 407, 1344

Location: It is in the small alleyway between the buildings. You can enter this lair once you have entered the Green Zone.

Lair 2

Green Zone - Lincoln Meadows

Coordinates: 835, 1181

Location: It is in a small park between the buildings.

Lair 3

Green Zone - Lincoln Meadows

Coordinates: 841, 1485

Location: It is in a small alleyway between the apartments.

Lair 4

Green Zone - Fulton

Coordinates: 702, 1278

Location: It is in a small alleyway between the buildings.

Lair 5

Green Zone - Fulton

Coordinates: 720, 1331

Location: It is in a small alleyway between the buildings.

Lair 6

Red Zone - Midtown

Coordinates: 372, 217

Location: It is in the street near the loading docks.

Lair 7

Red Zone - Midtown

Coordinates: 664, 225

Location: It is in the street near the Virus infected building (covered with Virus).

Lair 8

Red Zone - Times Square

Coordinates: 568, 130

Location: It is in the street near the Virus infected building.

Lair 9

Red Zone - Times Square

Coordinates: 661, 110

Location: It is in the street near the destroyed and infected building.

Search the indicated locations to find all 45 Black Boxes. A special symbol will appear when you are approximately within 150 feet of each Black Box. You can keep track of your progress through the in-game collectibles map, which will show you how many Black Boxes are in each area and how many you have found. The Black Boxes are indicated by a pulse on the in-game collectibles map; mark the pulse location, and search the area to find the Black Box. You can also enter the listed coordinates (longitude, latitude) into the in-game map to find the indicated Black Box more easily.

Yellow Zone

Fairview

1. Coordinates: 144, 1111 - It is left of the square-shaped area, on the grass.

2. Coordinates: 188, 1041 - It is on the building with a balcony and gate; on the balcony.

3. Coordinates: 353, 1055 - It is on the rooftop of the entrance building.

4. Coordinates: 352, 999 - It is behind the apartments, in the corner.

Oakhurst

5. Coordinates: 122, 1229 - It is on the side balcony of a bricked building just off the highway.

6. Coordinates: 224, 1274 - It is on the rooftop of the building.

7. Coordinates: 234, 1346 - It is on the side of the rusted small house.

8. Coordinates: 312, 1191 - It is on top of the ledge near the back of the church.

9. Coordinates: 464, 1145 - It is at the quarantine on the rooftop between two large buildings.

Linden Park

10. Coordinates: 74, 1460 - It is on top of the crane machine, at the loading docks.

11. Coordinates: 157, 1464 - It is at the stadium, on a ledge below the broken sign that says "ROSMAN STADIUM".

12. Coordinates: 420, 1286 - It is on the rooftop next to the "RAD" sign on the glass building.

13. Coordinates: 490, 1399 - It is on the side the balcony near the rusted shacks.

Green Zone

Salt Yard Plains

14. Coordinates: 673, 1639 - It is between the two pipes on top of the Blackwatch factory.

15. Coordinates: 689, 1572 - It is near the rooftop entrance of the factory.

16. Coordinates: 695, 1495 - It is on the rooftop of the hotel.

17. Coordinates: 750, 1540 - It is by the building in the parking lot.

Lincoln Meadows

18. Coordinates: 846, 1203 - It is on the rooftop of the building next to the large pillar attached to the building.

19. Coordinates: 870, 1326 - It is near the two air conditioners on the building with green rooftop.

20. Coordinates: 876, 1156 - It is on the rooftop of the apartment next to the water tower.

21. Coordinates: 910, 1464 - It is on the rooftop of the hotel behind the billboard.

22. Coordinates: 966, 1414 - It is near the red building by the street intersection, in the bushes.

Fulton

23. Coordinates: 653, 1358 - It is on the rooftop of the building near the billboard.

24. Coordinates: 666, 1220 - It is on the rooftop of the factory.

25. Coordinates: 720, 1417 - It is on the rooftop of the restaurant building.

26. Coordinates: 726, 1261 - It is on the theater rooftop near the water tower.

27. Coordinates: 739, 1142 - It is on the freeway bridge near the freeway pillar.

Red Zone

Chinatown

28. Coordinates: 417, 436 - It is on the rooftop of the building, near a large air conditioner.

29. Coordinates: 457, 535 - It is at the top of the office building.

30. Coordinates: 634, 510 - It is on the rooftop of the building, behind the chimneys.

31. Coordinates: 724, 460 - It is on the rooftop of the building, by the two yellow air conditioners.

32. Coordinates: 730, 534 - It is on the rooftop between the two large buildings.

Midtown

33. Coordinates: 448, 197 - It is on the rooftop of the building, near the glass ceiling.

34. Coordinates: 456, 328 - It is inside the broken building, on the rooftop.

35. Coordinates: 564, 268 - It is on the broken ladder inside the building.

36. Coordinates: 601, 230 - It is on the rooftop, in the middle.

37. Coordinates: 687, 326 - It is on the grass rooftop of the building.

38. Coordinates: 748, 216 - It is on top of the Crytiek building in the Blackwatch stronghold.

Times Square

39. Coordinates: 417, 91 - Jump inside the building from the top to find it.

40. Coordinates: 469, 93 - It is on the rooftop near the water tower on top of the small building.

41. Coordinates: 534, 84 - It is on the small balcony by the Mercer Virus infected building.

42. Coordinates: 556, 123 - It is on a ledge by the destroyed sign and virus infected building.

43. Coordinates: 628, 130 - It is inside the building, two floors down from the rooftop.

44. Coordinates: 679, 103 - It is near the lair, on the rooftop of the building with a green roof.

45. Coordinates: 719, 67 - It is on the rooftop of the Times Square train station, near the air conditioners.

Field Ops locations

Search the indicated locations to find all 28 Field Ops teams. When you find a Field Ops team, you must kill all of them. You can keep track of your progress through the in-game collectibles map. The Field Ops teams are indicated by a small pulse on the in-game collectibles map; mark the pulse location, and search the area to find the Field Ops team. You can also enter the listed coordinates (longitude, latitude) into the in-game map to find the indicated Field Ops team more easily.

Yellow Zone

Fairview

1. Coordinates: 123, 1049 - It is behind the fence of the blue building.

2. Coordinates: 268, 929 - It is at the top of the Yellow Zone area, near the Blackwatch stronghold crawling with enemies.

3. Coordinates: 292, 1085 - It is behind the building.

4. Coordinates: 398, 982 - It is near the docs.

Linden Park

5. Coordinates: 41, 1539 - It is at the end of the loading docks.

6. Coordinates: 382, 1512 - It is under the freeway bridge.

7. Coordinates: 427, 1409 - It is in a small park between the buildings.

Green Zone

Lincoln Meadows

8. Coordinates: 821, 1521 - It is by the building with the sign that says "WORLDWIDE WAREHOUSE 7".

9. Coordinates: 846, 1157 - It is in the alleyway between the apartments.

10. Coordinates: 883, 1527 - It is behind the store.

11. Coordinates: 927, 1272 - It is on top of the building, by the helipad.

Fulton

12. Coordinates: 612, 1313 - It is near the docks behind the building.

13. Coordinates: 705, 1305 - It is in an alleyway between the buildings.

14. Coordinates: 727, 1427 - It is in an alleyway between the buildings.

15. Coordinates: 745, 1164 - It is under the freeway bridge near the fence.

Red Zone

Downtown

16. Coordinates: 535, 773 - It is on the rooftop of a building.

17. Coordinates: 540, 912 - It is on the ground level of the building near the ocean.

18. Coordinates: 585, 662 - It is on the rooftop of the building near the yellow air conditioners.

19. Coordinates: 639, 819 - It is at the top of the glass office building.

20. Coordinates: 765, 666 - It is on the rooftop of a building.

Chinatown

21. Coordinates: 461, 427 - It is on the rooftop of a building between two air conditioners.

22. Coordinates: 573, 559 - It is in the middle of a rooftop on a building.

23. Coordinates: 620, 439 - It is on the rooftop of a building.

24. Coordinates: 750, 425 - It is on the rooftop of a building.

Midtown

25. Coordinates: 283, 253 - It is at the loading docks near the ocean.

26. Coordinates: 410, 233 - It is on the rooftop of the building near the Blackwatch stronghold.

To get the "Icarus" and "So Above It All" achievements, you must have access to the Empire State Building, which is the tallest building in the game. It is on Manhattan Island, inside the Red Zone, which you will not have access to until later in the game. Go to the 678, 258 coordinates on your map, and wall run to the top of the building. You should get the "Icarus" achievement before reaching the very top of the building. To get the "So Above It All" achievement, you must have the Movement skill upgraded to the max. You will also need the Jumpy, Dashing, and Jet Propulsion mutations. The Whip-Fist and Extra Dashing mutation are helpful but not required. Run as far as possible up the Empire State Building, then use a fully-charged jump, and immediately begin holding [Glide]. Make sure to save your air-dashes. Pump [Glide] to gain a few extra seconds of hang-time. Once you start to lose forward momentum and start falling, use the air-dash to regain your glide, and repeat the process. Make sure to keep using your remaining air-dashes to stall your fall. You can also use the Whip-Fist attack to pause in mid-air for a few extra seconds.

Easy "The Floor Is Lava" achievement

It is recommended you try to get "The Floor Is Lava" achievement later in the game after the Red and Green Zones are unlocked, but it can also be obtained in the Yellow Zone. Start on one side of the map, and set a waypoint marker on a far off part of the map. Try setting the waypoint marker from the south-east corner of the Yellow Zone to the western edge. Choose a tall building to start from, and start gliding. Keep finding buildings to wall run up, charge your jump, and repeat the process. Keep repeating this until you get "The Floor Is Lava" achievement.

Achievements

Accomplish the indicated achievement to get the corresponding number of Gamerscore points:

Anger Management (20 points): Destroyed 5 vehicles using a Finisher.

So Above It All (20 points): Spend at least 25 consecutive seconds in the air (helicopters don't count).

Vitamin B-rains (10 points): Acquired 10 upgrades through Consumes.

Eating Your Way to the Top (30 points): Acquired 30 upgrades through Consumes.