Poliovirus Replication Cycle

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Description

Poliovirus is a member of the Picornaviridae family, which includes a number of
significant pathogens of humans (e.g., Rhinoviruses, Coxsackieviruses,
Echoviruses, Enteroviruses, and Hepatitis-A virus) and livestock (e.g.,
foot-and-mouth disease viruses). Poliovirus has three known serotypes: PV1, PV2,
and PV3 and all three serotypes can cause poliomyelitis, a paralytic disease
resulting from the destruction of motor neurons in the CNS (Central Nervous
System). All the three serotypes of Poliovirus recognize a common cellular
receptor, CD155 (or PVR, Poliovirus Receptor), for cell attachment and entry.
CD155 is a transmembrane glycoprotein belonging to the immunoglobulin
superfamily. The ectodomain of CD155 mediates cell attachment to the ECM
(Extracellular Matrix) molecule vitronectin, while its intracellular domain
interacts with the dynein light chain. The virus [...]