Preparation and Storage

General Info

Alternative names

AChR

Beta-3 subunit precursor

CHRNB3

Neuronal acetylcholine receptor protein

Relevance

The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be (hetero)pentamers composed of homologous subunits. The subunits that make up the muscle and neuronal forms of nAChRs are encoded by separate genes and have different primary structure. There are several subtypes of neuronal nAChRs that vary based on which homologous subunits are arranged around the central channel. They are classified as alpha-subunits if, like muscle alpha-1, they have a pair of adjacent cysteines as part of the presumed acetylcholine binding site. Subunits lacking these cysteine residues are classified as beta-subunits.

Cellular localization

Cell Membrane

Images

ab158118 on a 12.5% SDS-PAGE stained with Coomassie Blue.

References

ab158118
has not yet been referenced specifically in any publications.

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