CHAMPAIGN, Ill. -- Preliminary but cautiously given good news for aging
Great Lakes fish-eaters: First-round tests of fine motor skills showed barely
a hint that years of consuming PCB- and DDE-contaminated fish have had any
negative effects.

The study, when completed, will provide a rare, comprehensive look at
the effects of environmental contaminants on older people. Scientists began
a neurological assessment in 1992 of a group of men and women older than
age 50 who have consumed 24 or more pounds of sport-caught Lake Michigan
fish annually since the 1960s. A comparable group from the same region who
didn't eat fish also is being studied. The fish-eaters have elevated levels
of several contaminants, including PCBs and DDE (a derivative of the pesticide
DDT).

Preliminary test results of dexterity and hand steadiness were presented
May 12-15 in Montreal during Health Conference '97, which was devoted to
pollution of the Great Lakes Basin. An overview of the project -- funded
by the Agency for Toxic Substances and Disease Registry of the U.S. Department
of Health and Human Services -- was published last year in the journal Toxicology
and Industrial Health.

"People eating fish in the 1960s and '70s were really getting the
highest level of exposure," said principal investigator Susan L. Schantz,
a professor of environmental toxicology at the University of Illinois. "PCBs
and DDE are not very easily metabolized; they tend to accumulate in body
fat."

Animal research has shown that PCBs (polychlorinated biphenyls) -- a
group of industrial chemicals toxic in the environment -- decrease dopamine
levels in the brain. In Parkinson's disease, too little dopamine contributes
to a reduction of motor function and executive abilities (planning and attention).

"We thought that we might see reduced motor function," she
said. "At this point, however, it doesn't look like it. We've only
looked at two of a large number of tests that we have yet to '"/>

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