The UEFA Champions League returns this week, and Christian Pulisic and Borussia Dortmund kick off the group stages with a major test.

Pulisic and co. will face off with Tottenham on Wednesday in one of the day’s marquee Champions League clashes. The matchup will be vital due to the makeup of the group, which also features reigning champion Real Madrid.

Matt Miazga and Aaron Schoenfeld will then take the field in Europa League action on Thursday, with Miazga and Vitesse opening their run in the competition against Italian side Lazio. Schoenfeld and Maccabi Tel Aviv, meanwhile, face Slavia Prague.

Elsewhere, Omar Gonzalez and Jorge Villafana headline a contingent of Americans that could see the field in Copa MX play while Tim Ream, Lynden Gooch, Eric Lichaj and Cameron Carter-Vickers look to make an impact in Championship action.