In this new paper Itay tested OSKM trans-differenitation method using genetic lineage tracing for expression of endogenous Nanog and Oct4 and for X chromosome reactivation. He found that the vast majority of reprogrammed cardiomyocytes or neural stem cells obtained from mouse fibroblasts by this method pass through a transient pluripotent state, and that their derivation is molecularly coupled to iPSC formation mechanisms.

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Feb.

Scientists Complete First Steps Toward Making Sperm and Eggs From Skin Stem Cells