GOODYEAR, Ariz. (AP) — Justin Masterson struck out two in a scoreless inning, catching prospect Jake Lowery hit a grand slam and the Cleveland Indians homered three times overall during a 12-3 victory over the Cincinnati Reds on Thursday.

Elliot Johnson and Tyler Naquin added two-run homers.

Carlos Santana made his first start at third base for the Indians, who are trying the catcher at a new position. He had a single in two at-bats but no chances in the field.

Zach Cozart had a two-run double for the Reds. Leadoff hitter Billy Hamilton singled in two at-bats.

Masterson started and gave up one hit. Reds starter Johnny Cueto gave up a hit and a pair of walks and struck out two in two scoreless innings, a successful debut for his shortened delivery.