Deadpool #250 (A.K.A. #45) comes out tomorrow April 8, 2015 and is the final issue of the series. A preview of this issue can be seen here.

DEADPOOL NUMBER 250! (A.K.A. issue #45)
GERRY DUGGAN, BRIAN POSEHN, BEN ACKER, BEN BLACKER, NICK GIOVANETTI, PAUL SCHEER, JASON MANTZOUKAS, MIKE DRUCKER, & MORE (w) MIKE HAWTHORNE, SCOTT KOBLISH, & MORE (a)
Cover by SCOTT KOBLISH
RUN THE JEWELS VARIANT COVER BY SKOTTIE YOUNG
DEATH OF DEADPOOL VARIANT COVER BY TBA
AVENGERS VARIANT COVER BY TBA
WTD VARIANT COVER BY TBA
FINAL ISSUE!
That’s right—if you add together all the Deadpool series (creatively) issue 45 is the big 250th issue of Deadpool! What better way to celebrate than to end the series? In our over-sized main story, ULTIMATUM comes at Deadpool for revenge, so he has no choice but to take them on—ALL OF THEM. Then, in an Infinity Gauntlet crossover, what would Deadpool do if he got the six gems from Thanos? Plus: a slew of stories showcasing Deadpool’s closest friends and allies by special guest writers! Also, SPOILER: Deadpool dies at the end of the issue.