With three matches in the regular season remaining, play-off places, European slots and relegation are all yet to be decided.

But with some crucial clashes this weekend, we will have a much clearer idea of the final league table by Sunday afternoon.

The full round of fixtures kicks off tonight at Kingsholm with Gloucester against Exeter Chiefs – rugby’s Leicester City as the surprise package of the season – but the biggest game of the lot is arguably at Wembley on Saturday.

Saracens have sold 82,000 tickets to the Harlequins derby already – looking to break their attendance record of 84,068 from the same fixture last year.

And with a flurry of England stars on show it is set to be a weighty contest.

Here, Sportsmail runs you through the rugby weekend.

Billy Vunipola and Saracens host London rivals Harlequins at Wembley in a bumper weekend of action

Wasps’ backs are flying right now and have their sights firmly set on a first play-off appearance since Lawrence Dallaglio lifted the title in his last ever match back in 2008.

They have pace to burn with the likes of Christian Wade, Dan Robson, Frank Halai and Elliot Daly all in great form. Having snuck past Exeter in Europe Wasps face a Worcester side intent on ousting Bath for ninth place.

But the Warriors’ run-in is treacherous, with Leicester and then Saracens left to play – so they could have a real say in the outcome of the final table.

KEY STAT

If Worcester beat Wasps it will be the first time since December 2012 they have remained unbeaten at home for four consecutive matches.

Prediction: Away win

Wasps have been on fire this season and got the better of Exeter in Europe in their last match

Wembley will be packed to the gunnels for this Derby Day fixture. Saracens have been masters of all they survey this year and it would represent a real failure if they did not win back-to-back league titles.

Maro Itoje (right) is rested by Saracens but George Kruis (left) starts at lock for the game with Harlequins

England fly-half or centre Owen Farrell has to make do with a place on the bench this weekend

But there is still plenty of talent for Eddie Jones to keep an eye on, with the Vunipolas, George Kruis and Alex Goode all playing.

Quins have somewhat of a psychological hex against Saracens. Despite beating them at the Stoop in January their last win against the Barnet side before that came at Wembley in 2012 – the year they won the league.

Conor O’Shea has said this match is do-or-die for Harlequins and he is right.

The top-four looks a long shot but Champions Cup qualification is achievable, if they win at least two of the last three to stave off Sale for sixth place.

KEY STAT

This is Saracens’ 13th visit to Wembley. They have only lost at the ground three times - to Leinster, Toulouse, and to Harlequins in 2012.

Prediction: Home win

Jamie Roberts is one of the big names in the Harlequins side which will face Saracens at Wembley

The reverse fixture provided a dramatic climax, with Leicester winning 30-27 at the death, so more of the same would be welcome on Saturday.

This derby is always feisty and this version has the added spice, as the winner will take fourth place with two games to go in the season.

England captain Dylan Hartley is still being nursed back to fitness after his concussion on England duty

Dylan Hartley is still being nursed back to fitness after his concussion against France but Kieran Brookes, Courtney Lawes (at six), Luther Burrell and Tom Wood are those with England credentials to prove.

Leicester have a European semi-final against Racing 92 to look forward to, but another Premiership title would surely confirm the city as the British sporting capital in 2016, with the football side’s remarkable run.

It has been an awful time for Bath this year. Last year’s losing finalists are languishing in ninth –they may have the millions of Chairman Bruce Craig, but it has not produced anything on the pitch this year.

At times the South West club have been embarrassing and are looking to save face at the end of this season. That will be tough against a Sale side, commanded by Danny Cipriani, who have only lost once at home since January 2015.

Rhys Priestland starts at full-back for Bath as George Ford captains the side.

KEY STAT

The last time Bath finished ninth or lower in the Premiership was in 2006.

Prediction: Home win

England fly-half George Ford captains Bath from number 10 against Sale at the AJ Bell Stadium

As relegation scraps go, this is a big one. London Irish, who looked dead and buried a few weeks ago, know a win will suddenly put them level on points with Newcastle – a bonus point win and they will be ahead.

Irish have been by far the worst team in the league so to escape now would be remarkable.

Newcastle have opened the door for Irish, rather than the Reading side pulling themselves out of the mire. The Falcons have lost six in-a-row but still should stave off Irish.