Medical Journal of the Islamic Republic Of Iranمجله پزشکی جمهوری اسلامی ایرانMed J Islam Repub IranMedical Scienceshttp://mjiri.iums.ac.ir2journal21016-14302251-6840810.18869/mjiri14888813enjalali137951gregorian200081142online1fulltextenSUSCEPTIBILITY OF HUMAN WM MELANOMA CELL LINES TO NK AND LAK CYTOTOXICITY AND THEIR RELEVANCE TO THE LEVEL OF MHC CLASS I AND ICAM-l ANTIGEN EXPRESSIONImmunologyImmunologyOriginal Research: Basic Science in MedicineOriginal Research: Basic Science in MedicineThe effect of natural killer (NK) cells and lymphokine activated killer
( LAK) cells was studied on a group of human melanoma cell lines. Peripheral
blood from healthy volunteers was utilized as a fresh source of natural killer
cells and rhI L-2 for producing LAK cells. The cytotoxicity of effector cells
was quantified using a 4 hour SI determining the density of antigen expression on tumor cell surface. The majority
of WM melanoma cell lines were relatively resistant to lysis by NK
cells, but all showed high sensitivity to LAK cytotoxicity. The expression of
MH C class I and I CAM-l on tumor cell lines varied, however using linear
regression analysis between MH C class I and I CAM-l antigen expression,
and UK/ pression of these antigens on the WM melanoma cell lines tested are independent
of NK/
155160http://mjiri.iums.ac.ir/browse.php?a_code=A-10-298-335&slc_lang=en&sid=enARANDALIB2003194753284600444020031947532846004440Yes
From Isfahan Medical School, Isfahan, I.R. IranJLAWRY2003194753284600444120031947532846004441Nothe Immunology Section of the Institute for Cancer Studies, Sheffield Medical School"Sheffield,. UK.R.cREES2003194753284600444220031947532846004442Nothe Department of Life Sciences, the Nottingham Trent University, UK.