This study provides novel insight into the role of H3K27 trimethylation in cancer-specific epigenetic gene silencing.

Using chromatin immunoprecipitation in prostate cancer cells, the authors show that H3K27 trimethylation constitutes an epigenetic gene silencing pathway that is independent of DNA methylation and H3K4/K9 methylation.

These findings might be important for developing future concepts of epigenetic cancer diagnosis...

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