Penetration of fluoroquinolones into prostate

In addition to discomfort, prostatitis syndromes are responsible for substantial physical and emotional distress [ 16 , 17 ] and financial costs [ 14 ]. Ciprofloxacin has been shown to be more effective than trimethoprim-sulfamethoxazole and aminoglycosides in seven- to day courses for the treatment of complicated urinary tract infections. Fluoroquinolones have the best penetration into prostatic tissue of all currently available antibiotic classes of drugs. Certainly, cerebrospinal fluid, the vitreous of the eye, and the prostate must rank as the most important sites to delineate penetration before clinical trials 2. One major change was the development of a National Institutes of Health NIH consensus definition and classification system Table 1 [ 4 , 5 ]. J Clin Microbiol ,

Epidemiology

A Population Pharmacokinetic Analysis of the Penetration of the Prostate by Levofloxacin

For antibiotic therapy, I prefer to do a culture and treat according to the sensitivities I find. Acute bacterial prostatitis is easily diagnosed by abrupt urogential and often systemic symptoms, along with bacteriuria and treated by systemic antibiotic therapy. Indexed in Science Citation Index Expanded. Some debate the role of gram-positive organisms other than enterococci [ 36 , 37 ], but most accept Staphylococcus and Streptococcus species as pathogens [ 37—39 ]. Aside from acute bacterial prostatitis, the precise etiology and pathogenesis of the other types of prostatitis outlined in the NIH classification remain to be fully elucidated.

Prostatitis - Infectious Disease and Antimicrobial Agents

All antibiotics have side effects, most mild and self limited, some serious and permanent. Proteus mirabilis Pseudomonas aeruginosa. Scand J Infect Dis 28 Suppl. It was recently reintroduced in Canada and is indicated for the treatment of acute uncomplicated cystitis in adult women infected with susceptible isolates of E. The normal pH of human prostatic fluid is 6.