Brief description of study

The purpose of this study is to compare overall survival rates of colorectal cancer patients
with multi-organ metastases with an indication for first line systemic treatment randomized
for treatment with combination chemotherapy or treatment with combination chemotherapy and
additional maximal tumor debulking including surgical tumor resection, RFA, (DEBIRI-)TACE and
SBRT, depending on best clinical judgement according to a standardized treatment algorithm.
Our hypothesis is that maximal tumor debulking in addition to systemic treatment with
chemotherapy and biologicals will provide an improvement in progression free and overall
survival in this patient group.