The two fugitives accused in the cold-blooded shooting of heralded Harlem high school basketball star Tayshana “Chicken” Murphy are back in Manhattan and have been indicted in her murder.

Tyshawn Brockington, 21, and Robert Cartagena, had been hiding out in the Columbia, SC, home of a girlfriend. Manhattan Criminal Court Judge Abraham Clott ordered they be held without bail.

The two were overheard at the scene some 15 minutes before the shooting saying they were going to “smoke” someone, according to court documents.

Murphy, 18, a senior at Murry Bergtraum High School for Business Careers, had been considered one of the country’s best young point guards. Almost 2,000 family members and friends had crowded her funeral in Astoria last month.

She was shot as she fled her murderers, running up four flights of stairs — screaming, “I’m not with that!” — in the Grant Houses project, her home.

One of the murderers answered “I don’t give a f—” before three shots rang out, according to unnamed earwitnesses quoted in court documents.

Police would only say she got mixed up in a dispute involving violent thugs from the rival Manhattanville projects a few blocks away.

But relatives of Murphy told the Post she died trying to protect her beloved 16-year-old brother, who had somehow angered the two alleged killers.

Surveillance video captured Brockington and Cartagena at the scene with guns in their waistbands, Police Commissioner Ray Kelly has told reporters.

The two will plead not guilty when they are formally arraigned on their second degree murder indictments in Manhattan Supreme Court on October 18, said defense lawyers Daniel Gotlin and Daniel Parker.

A third suspect, Terique Collins, 24, has been charged with criminal possession of a weapon for allegedly providing Brockington and Cartagena with the gun that killed the tragic teen.