Category: Research

Caloric restriction has long been known to increase the lifespan and healthspan of most studied animals. Research also shows that animals given a calorie-restricted diet are also generally more able to regenerate tissue damage following injury. Caloric restriction improves tissue regeneration A new study by the Lengner lab at the University of Pennsylvania has identified…

In a new study, researchers at the Johns Hopkins Kimmel Cancer Center have shown that the epigenetic alterations associated with cancer evolve in an erratic manner during the early stages of tumor formation [1]. These tumor-associated epigenetic changes ultimately focus on a subset of genes that are also observed in aging. Cancer and senescent cells…

The latest of the regular “commentary on some recent theses” publications by Dr. Aubrey de Grey and collaborators has been released today. As is usual in these pieces, there is commentary on a variety of recent research topics, including the cellular senescence of astrocytes in the brain, which may lead to new therapies to combat…

Today, we wanted to highlight more progress in a rapidly advancing area of medicine and talk about a new study that uses an exosomes-based approach for stroke treatment that repairs brain tissue. A stem cell-based approach to treating stroke Professor Steven Stice from the University of Georgia (UGA) and Nasrul Hoda of Augusta University led…

Today, we would like to highlight a recent study in which researchers show a way to selectively accelerate bone regeneration. They have achieved this by delivering Jagged-1 to injuries instead of the bone morphogenetic proteins (BMPs) that have been traditionally used. What is jagged-1? Jagged-1 is an osteoinductive protein that activates the Notch signaling pathway,…

Researchers have created tiny DNA nanorobots that can deliver a protein payload that cuts off the blood supply to tumors in mice. DNA Origami According to a new study, the research team was able to create DNA nanorobots that can travel through the bloodstream, locate tumors, and deliver a protein that induces blood clotting, thus…

There may be other methods than drugs to destroy senescent cells, which accumulate with age. The immune system fails as we age, and rejuvenating it may be another route to removing harmful, pro-aging senescent cells. Senescent cells and senolytics As your body ages, increasing amounts of your cells enter into a state of senescence. Senescent…

What if I told you that we could regenerate our teeth? Well, that may soon be a possibility thanks to new research showing that teeth can be encouraged to regrow. Rather than drilling holes into teeth and plugging them with artificial fillers, dentists in the near future may be able to rebuild your teeth with…

We wanted to bring your attention to an open-access publication in which the researchers suggest that the age-related decline of the thymus is more important than DNA mutation as a cancer risk factor[1]. Repairing the damage As we have discussed in this article, cancer is caused by DNA damage that creates mutations. Damage to our…

New research from the University of Southern California has shed light on how the decline of the brain’s vascular system precedes the build-up of the plaques and tau tangles associated with Alzheimer’s disease. A leaky blood-brain barrier sets the scene for dementia Traditionally, many researchers have focused their efforts on the amyloid and tau proteins…