Until it got retconned by "Bender's Big Score" the ending to Futurama's "Jurassic Bark" was the saddest ending to a television episode I had ever seen. What is most annoying, is by retconning the ending... yes it is less sad but the emotional impact of that ending was ripped away. It is less than it was and that is not a good thing. The other one that gets me is Trigun's "Paradise." Not because of the major character death that takes place in that episode, that is sad... but the scene that get to me is Milly's reaction later. She is always so optimistic, upbeat, happy... seeing her devastated and weeping just destroys me.

Endings of Grave of the Fireflies, Requiem for a Dream, Donnie Darko, Life is Beautiful and Boy with the Striped PJs

Rabies in ScrubsBrooks was hereIn the Pale Moonlight DS9Not Penny's BoatG'Kar freedom speechAvacato hugging his son back on Galaxy 1 in Final SpaceJurasic BarkAll of the Strike teams endings in The ShieldJane in Breaking BadThe human becoming insurgents in BattleStar Galactica. Probably more what happened to those who wouldn't be an insurgent.Maes Hughes

One for me, for some reason - The death of Ophelia in Mel Gibson's Hamlet always makes me tear up.

Also, the poetry as Depp channels Thompson reminiscing about the 60s in Fear and Loathing in Las Vegas, alternately called 'The Wave Speech' or 'The High Water Mark monologue'. It makes me feel I was born in the wrong time.

I think the thing that usually gets me are where characters have been struggling so hard against a tragedy (even if self-inflicted), and the point finally comes where they can't contain the force of it any more and they break. So for instance when the guilt eventually cuts through the amnesia in The Machinist, the revelation of the trauma of the mentally ill man in Spider, or the first season of Fleabag as her defensive facade of fun woman-around-town finally collapses under the strain. I suppose this idea might include that most shameless of tearjerkers, Cinema Paradiso, although that's a little sentimental for my tastes.

Other than that, the start montage from Pixar's "Up!" summarising the old guy's life is one of saddest moments you'll find in a film.

Dang, beat me to it. Part of why I don't believe Toy Story 4 should exist.

Even now that the cast has mostly recovered from the trauma, the finale of Volume 3 in RWBY.

Agents of SHIELD, the last 1/3rd of Season 4. Technically this means the team all have two lives' worth of memories in them, souls grown old before their time, with Fitz having it the worst of all. If they don't give him further conflict with this and [CLASSIFIED] in the coming seasons I'll go around town for a week saying nothing but 'Hail Hydra'.

Agema:I think the thing that usually gets me are where characters have been struggling so hard against a tragedy (even if self-inflicted), and the point finally comes where they can't contain the force of it any more and they break. So for instance when the guilt eventually cuts through the amnesia in The Machinist, the revelation of the trauma of the mentally ill man in Spider, or the first season of Fleabag as her defensive facade of fun woman-around-town finally collapses under the strain. I suppose this idea might include that most shameless of tearjerkers, Cinema Paradiso, although that's a little sentimental for my tastes.

Other than that, the start montage from Pixar's "Up!" summarising the old guy's life is one of saddest moments you'll find in a film.

Damn. That reminded me of Memento. But more for the cop, than the main character

Agema:I think the thing that usually gets me are where characters have been struggling so hard against a tragedy (even if self-inflicted), and the point finally comes where they can't contain the force of it any more and they break. So for instance when the guilt eventually cuts through the amnesia in The Machinist, the revelation of the trauma of the mentally ill man in Spider, or the first season of Fleabag as her defensive facade of fun woman-around-town finally collapses under the strain. I suppose this idea might include that most shameless of tearjerkers, Cinema Paradiso, although that's a little sentimental for my tastes.

Other than that, the start montage from Pixar's "Up!" summarising the old guy's life is one of saddest moments you'll find in a film.

Fleabag! I don't know anyone else that has watched that magnificent show. Terrific show. I love when she speaks with a man that is going through a group thing with men. He speaks of how he wants to be better and let his wife know how much he adores her. Gotta stop typing. Getting vaklempt.

Fry's dog Seymour in "Jurassic Bark" is the obvious choice however, even thinking about that moment in the "Luck of the Fryrish" episode of Futurama when Fry finally realizes his brother didn't steal his identity but instead missed him so much that he named his son after him will get me going every time. If I were an actor, that'd be my go to for sad scenes.

A close second is the later series episode "Game of Tones" when he talks to his mom in her dream.

And now I'm crying on a bus, great. Goddamn. How is a cartoon this powerful? What a terrific series that was.

The endings of Now And Then, Here And There and Saikano aka She: The Ultimate Weapon. As far as anime goes those are some peak fucking sadness and as far as I'm aware no one really knows about them. Possibly because they're 20 years old holy shit I'm old.

While looking up NaTHaT I also found out its been compared to Grave Of The Fireflies, so hey, if proof be needed.