Tooth loss is a huge problem of the modern man. Use of new technologies and dental materials in the fabrication of fixed or mobile dental prosthetic appliances has an impact on the change of some of the biochemical parameters in the patient saliva. It is thought that to a degree, particular materials have an impact on the change of quality and quantity of saliva after their placement in the mouth cavity. The presence of metal ions as free ions in the mouth has got a large potential for the creation of factors that cause oxidative stress. A specially adverse effect has been observed with alloys used in the fabrication of fixed dental prosthetic appliances, since they cause allergic and hypersensitivity reactions in the mouth cavity. It has been shown that use of dental prosthetic appliances induces changes in the morphology and reduced motility of the cells, significant increase of oxidative stress, appearance of cytokines, and cell intoxication. With the placement of fixed dental prosthetic

appliances patients tend to adapt to them much quicker than with mobile appliances, when the clinical signs of inflammation are much more common. With the application of fixed dental prosthetic appliances oxidative stress in the saliva is much less intense than with mobile appliances. A similar relationship has been found in the analysis of parameters of inflammation and markers of apoptosis in the saliva. Increased parameters of inflammation, oxidative stress, and apoptosis in the saliva of patients as the result of fixed dental prosthetic appliances, tend to normalize much more rapidly than with mobile appliances. The analyzed biochemical parameters normalize 30 days after the placement of fixed or mobile dental prosthetic appliances.