Vascular heterogeneity and specialization in development and disease Michael Potente & Taija Mäkinenp477 | doi:10.1038/nrm.2017.36Blood and lymphatic vessels have essential roles in physiology and disease. The endothelial cells that line these vessels specialize to fulfil the needs of the tissue that they pervade. Recent studies in animal models have provided insights into the mechanisms underlying vessel type- and organ-specific specialization, which is crucial for the understanding of several diseases.Abstract | Full Text | PDF

TIMELINEArticle series: Post-translational modificationsThe winding path of protein methylation research: milestones and new frontiers Jernej Murn & Yang Ship517 | doi:10.1038/nrm.2017.35Protein methylation was discovered over 50 years ago, but only with the advent of genomic and proteomic technologies could its mechanisms and cellular functions be studied in detail. Shi and Murn discuss the seminal discoveries in protein methylation research and highlight future directions for this field.Abstract | Full Text | PDF

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