Xenograft and orthotopic models of prostate and colon cancer were used to assess the effect of PIM activation on the efficacy of VEGF-targeting agents. Immunohistochemistry and in vivo imaging were used to analyze angiogenesis, apoptosis, proliferation, and metastasis. [Clin Cancer Res]
Abstract

Investigators report an attomolar detection of miR141 and miR375 released from living prostate cancer cells by using a plasmonic nanowire interstice sensor. This sensor showed a very low detection limit of 100 aM as well as a wide dynamic range from 100 aM to 100 pM for all target miRNAs. [Nanoscale]
Abstract | Graphical Abstract

Scientists demonstrated feasibility of enriching either PFA-fixed or viable cancer cells with a clinical scale acoustic microfluidic platform that can be adjusted to meet requirements for either high cancer cell recovery or higher purity, and can process five milliliter blood samples in close to two hours. [Anal Chem]
Abstract

Scientists determined the effects of exogenous testosterone on the growth of LNCaP, or androgen-independent C4-2 cells xenografted into zebrafish embryos. Testosterone significantly increased engrafted LNCaP proliferation compared to control xenografts, which could be inhibited by co-administration of the anti-androgen receptor drug, enzalutamide. [Sci Rep]
Full Article

Two series of 4-morpholino-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidine derivatives bearing pyrazoline moiety were synthesized; and their cytotoxicity in vitro were evaluated by 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide method against four human cancer cell lines including A549; PC-3; MCF-7; and HepG2 cell lines. [Molecules]
Full Article

The authors demonstrated that gallein can inhibit the β-ionone-induced cell invasiveness in vitro, as well as the spread of metastases in vivo. LNCaP cell invasiveness, assessed using spheroid cultures in collagen gels in vitro, was increased by β-ionone and the effect was reversed by co-administration of gallein. [BMC Res Notes]
Full Article

Current evidence suggests that inflammation and atrophy are involved in prostate carcinogenesis and suggests a role for the microbiome in establishing an inflammatory prostate microenvironment that might promote prostate cancer development and progression. [Nat Rev Urol]
Abstract

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Institut Curie and the Institut de Recherche Pierre Fabre will collaborate on new therapeutic strategies to advance cancer treatment for patients. The objective of this novel partnership is to dissect the biology of novel therapeutically tractable targets and evaluate the impact of innovative pharmacological approaches leveraging the Institut Curie’s biological models. [Pierre Fabre]
Press Release

Minneamrita announced that an IND application to the FDA for a Phase I trial of an oral formulation of the company’s Minnelide for patients with advanced cancers is now active. [Minneamrita Therapeutics LLC (Business Wire, Inc.)]
Press Release

The controversial chairperson of the science committee in the U.S. House of Representatives announced that he will not seek re-election to Congress next fall. The pending departure of Representative Lamar Smith could give the U.S. scientific community a chance to recalibrate a rocky five-year relationship with a key congressional committee. [ScienceInsider]
Editorial

The salary data are incomplete and — in some cases — appear to be incorrect. Some researchers are listed as earning nothing, and another study underway suggests a higher overall rate of pay for US postdocs. But the latest analysis underscores the challenges of getting basic information about an under-recognized and misunderstood segment of the academic workforce. [Nature News]
Editorial

Springer Nature, whose publications include Nature and Scientific American, acknowledged that at the government’s request, it had removed articles from its mainland site that touch on topics the ruling Communist Party considers sensitive, including Taiwan, Tibet, human rights and elite politics. [The New York Times]
Editorial