Acell Matristem Background

Recent advances in the world of Regenerative Medicine have been very exciting. Fingertips are being regenerated, organs and heart valves have been cloned and are successfully being implanted in patients. Now one of the leading innovators in the field of regenerative medicine, ACell, Inc., has asked the Plastic Surgeons at Dr. Gary Hitzig’s offices in Rockville Centre, NY to test the use of their MatriStem product for healing the wounds associated with hair transplant sites. Dr. Hitzig and his colleagues will examine MatriStem’s ability to reduce scar tissue and regenerate hair within the donor region of hair transplant patients. MatriStem will also be tested for cloning transplanted hair from the donor area and the beard and growing it in bald areas on the top of the scalp.

ACell’s patented Extracellular Matrix (ECM) products are covered by multiple 510(k) clearances and address important unmet clinical needs, providing safe, effective and therapeutic outcomes. Derived from porcine urinary bladders and referred to as UBM (urinary bladder matrix), trademarked as MatriStem™, ACell’s core technology is a naturally occurring, non-crosslinked, completely resorbable acellular biomaterial. A similar “first generation” ECM technology has been used to treat over 500,000 patients with remarkable effect. ACell’s MatriStem products are the next generation of ECM technology due to its unique characteristics featuring a basement membrane surface which is ideal for epithelial cell growth in many applications.

“We are growing new hair in prior donor scar sites as well as duplicating (growing multiple hairs from a single transplanted beard or donor hair) in the bald recipient area” states Dr. Ted Chaglassian, a Board Certified Plastic Surgeon and former Chief of Plastic Surgery at Memorial Sloan-Kettering Hospital and Attending Physician at Columbia Presbyterian Medical Center in NYC. He further states: “Where we go from here is anyone’s guess but the future of cloning growing hair has just been made a reality in the present!”. - reprinted with permission from Dr. Hitzig

Much has been written as of late in the use of PRP (Platelet Rich Plasma) Injections to slow down or stop balding as well as to re-grow miniaturizing scalp hairs. Much of the early reported variable successes (Greco1) have been attributed to the fact that there are significant vital proteins (Collagen IV etc.) as well as multiple growth factors (ie: VGRF) that are vital to terminal hairs along with hair survival and enhancement in general. It has been postulated (Greco1) that the addition of ECM (Extracellular matrix) may significantly improve the results.

We agree…

What Is ACell (Matristem)?

ACell is the by-product of urinary bladder tissue (which has remarkable regenerative properties). The product is stripped of all cells (ACell) as well as muscle tissue thereby preventing graft vs. host reactions (Allergic Reactions) when introduced in humans. The way it works (in wound healing) is by recruiting huge numbers of Adult Stem Cells along with tremendous blood supply to the sight of a wound. It then effectively changes these inactive Adult Stem Cells back into Progenitor Cells (the Active Form) to direct healing by duplication of normal tissue rather than scar formation which is the only method normally available to humans for healing. What is important to understand is that when we are in-utero (mother’s womb), we develop by the direction of Embryonic Stem Cells. Upon birth these stem cells still remain in our bloodstream, however they change to Adult Stem Cells which are inactive.

ACell also provides a multitude of growth factors and proteins necessary for tissue regeneration as well as a scaffold on which to reconstruct the tissue. The scaffold is only temporary and soon disappears allowing the healing and regeneration to be carried out by one’s own cells and tissue.

PRP Prepared and ready to mix with the Acell Matristem

Why ACell?

Matristem is unique in that it is Bi-Modal and contains a Basement Membrane necessary to attract and propagate both Epithelial and Endothelial Cells—necessary elements for duplication and restructuring of skin and hairs. Matristem works by setting up a temporary cellular scaffold or bridge and then by attracting massive blood supply plus Adult Stem Cells (there are large numbers of inactive adult stem cells circulating in all humans after we are born) to the site of injury where they are converted back into Progenitor Cells.

Preparation of the PRP

ACell also contains more than ample amounts of the necessary Proteins and Growth Factors to reconstruct and copy tissue along with nerves and appendages (hair for example). Recently it has been shown that PRP (as well as, we suspect , the serum from spun down arterial blood) contain large numbers of Adult Stem Cells. By pre-mixing the ACell with either the Arterial Serum (or more easily the PRP in a non-surgical patient) we are skipping the step of waiting for the Adult Stem Cells to migrate to the injection sites and in essence pre-activating the injections. The injection sites serve as microwounds which ACell requires to begin the healing (duplication) process. In our opinion, wounds cannot be superficial, but rather, must be down to the subcutaneous tissue level in order to maximize effectiveness.

Our future studies are focused on comparing side by side (in the same patient with thinning hair) the results of injections of PRP alone with PRP + Matristem. Early results in transplant patients (where it is easier to obtain Arterial blood from the surgical donor area) have shown that when Matristem plus spun down Arterial Blood Plasma are combined and then injected in thinning areas other than where the transplants are placed, there appears to be re-growth of these miniaturizing hairs. The results are still very early but make sense in light of previous reported (Greco1) PRP injection results. We postulate that there must also be some sort of Competitive Inhibition with the Androgen Receptors or interruption in delivery by Messenger RNA for this to actually succeed. We are working with Harvest Technologies (PRP Specialists) to see where this will take us.