Dr. Wyatt refuses to let Meredith give up on therapy, Alex learns the truth about Rebecca's medical condition, the Chief insists that Erica perform a risky surgery on his mentor, and after receiving news of Burke, Cristina continues to do things contrary.

The pregnant woman whom Alex tended to returns to see Alex. On Halloween, Meredith thinks her dead mother is haunting her, and Callie reveals to the other doctors that George and Izzie are having an affair.

Cristina searches for Preston but does not find him. After passing the exam, Meredith, Cristina, Izzie, and Alex are now residents and have their own set of interns, including George who failed the exam and has to repeat.