Regression of thoracic aortic plaques by statins was demonstrated. However, because of differences between the property of abdominal aortic plaque and thoracic aortic plaque, the regression effects on abdominal aortic plaque have not been observed. We aimed to determine whether the combination treatment of statin and bisphosphonate was more effective than statin or bisphosphonate treatment in regression of aortic plaques.

Basic objectives2

Efficacy

Basic objectives -Others

Trial characteristics_1

Confirmatory

Trial characteristics_2

Pragmatic

Developmental phase

Phase IV

Assessment

Primary outcomes

The changing rate (%) of hyperplasia in Maximal Wall Thickness after one year
...ATR + ETD group vs. of ATR group

Key secondary outcomes

The changing rate (%) of hyperplasia in Maximal Wall Thickness after one year
...ATR + ETD group vs. of ETD group
The changing rate (%) of Total Vascular Area and Lumen Area
The changing rate (%) of LDLchol value
...ATR + ETD group vs. ATR group,
ATR + ETD group vs. ETD group

The patients who have psychic disturbance, Collagen disease, liver renal dysfunction, heart disorder, cerebrovascular disorder, and or serious complications. The patients who were decided that participation is inappropriate for them by chief physician.