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Literally it means "There's no two without three, the four comes by itself", and is equivalent to the English assertion that good or bad things "always come in threes".

Lost your keys, flattened your car battery and broken a shoe in one morning? "Non c'è due senza tre" Three awful blind dates in a row? "Non c'è due senza tre" Need an excuse to eat one more chocolate? "Non c'è due senza tre!".