Causes The cause is not known, but scientists believe that a combination of several factors may be involved. Immunologic Environmental Infections Genetic

The cause is not known, but scientists believe that a combination of several factors may be involved.

Immunologic

Environmental

Infections

Genetic

- Immunologic generally accepted that MS involves an autoimmune process abnormal response of the body’s immune system is directed against the myelin (the fatty sheath that surrounds and insulates the nerve fibers) in the central nervous system The exact target that the immune cells are programmed to attack remains unknown. In recent years researchers have been able to identify which immune cells are *mounting the attack * some of the factors that cause them to attack * some of the sites/ receptors on the attacking cells. Ongoing efforts to learn more about the autoimmune process in MS helps us learn more about this mysterious disease

generally accepted that MS involves an autoimmune process

abnormal response of the body’s immune system is directed against the myelin (the fatty sheath that surrounds and insulates the nerve fibers) in the central nervous system

The exact target that the immune cells are programmed to attack remains unknown.

In recent years researchers have been able to identify which immune cells are

*mounting the attack

* some of the factors that cause them to attack

* some of the sites/ receptors on the attacking cells.

Ongoing efforts to learn more about the autoimmune process in MS helps us learn more about this mysterious disease

Environmental Cause MS is known to occur more frequently in areas that are farther from the equator. Some scientists think the reason may have something to do with vitamin D, which the human body produces naturally when the skin is exposed to sunlight. People who live closer to the equator are exposed to greater amounts of sunlight year-round. As a result, they tend to have higher levels of naturally-produced vitamin D, which is thought to have a beneficial impact on immune function and may help protect against autoimmune diseases like MS.

MS is known to occur more frequently in areas that are farther from the equator.

Some scientists think the reason may have something to do with vitamin D, which the human body produces naturally when the skin is exposed to sunlight. People who live closer to the equator are exposed to greater amounts of sunlight year-round. As a result, they tend to have higher levels of naturally-produced vitamin D, which is thought to have a beneficial impact on immune function and may help protect against autoimmune diseases like MS.

- Infectious exposure to numerous viruses, bacteria and other microbes during childhood can make it possible that a virus or other infectious agent is the triggering factor in MS. Severeal viruses are being researched to see if they can cause MS which include: Measles Canine distemper, Human herpes Epstein-Barr, Chlamydia Pneumonia

exposure to numerous viruses, bacteria and other microbes during childhood can make it possible that a virus or other infectious agent is the triggering factor in MS.

Severeal viruses are being researched to see if they can cause MS which include:

Measles

Canine distemper,

Human herpes

Epstein-Barr,

Chlamydia

Pneumonia

Genetic MS is not hereditary in a strict sense -but having a relative such as a parent or sibling with MS increases an individual's risk of developing the disease. Studies have shown that there is a higher prevalence of certain genes in populations with higher rates of MS. -Common genetic factors have also been found in some families where there is more than one person with MS. Some researchers theorize that MS develops because a person is born with a genetic predisposition to react to some environmental agent that triggers an autoimmune response Sophisticated new techniques for identifying genes may help answer questions about the role of genes in the development of MS.

MS is not hereditary in a strict sense

-but having a relative such as a parent or sibling with MS increases an individual's risk of developing the disease.

Studies have shown that there is a higher prevalence of certain genes in populations with higher rates of MS.

-Common genetic factors have also been found in some families where there is more than one person with MS.

Some researchers theorize that MS develops because a person is born with a genetic predisposition to react to some environmental agent that triggers an autoimmune response

Sophisticated new techniques for identifying genes may help answer questions about the role of genes in the development of MS.

Virul Cause It is tempting to speculate on a viral cause for MS for several reasons: *Viruses are known to cause demyelinating disease in animals and humans. Demyelination-destruction of myelin causes nerve impulses to be slowed or halted and produces the symptoms of MS. It is highly unlikely that MS can be caused by a virus

It is tempting to speculate on a viral cause for MS for several reasons: *Viruses are known to cause demyelinating disease in animals and humans.

Demyelination-destruction of myelin causes nerve impulses to be slowed or halted and produces the symptoms of MS.

It is highly unlikely that MS can be caused by a virus

Data from epidemiological studies those that analyze variations in geographical, socioeconomic, genetic, and other factors suggest that exposure to an infectious agent may be involved in causing MS. - Some viruses are known to have a long latency period between time of infection and appearance of clinical symptoms, as is thought to be the case in MS. -Increased antibodies to many different viruses have been found in the blood and cerebrospinal fluid of people with MS However, this does not necessarily represent disease-causing infection by these viruses. It is more likely to be the result of non-specific immune activation

those that analyze variations in geographical, socioeconomic, genetic, and other factors suggest that exposure to an infectious agent may be involved in causing MS.

- Some viruses are known to have a long latency period between time of infection and appearance of clinical symptoms, as is thought to be the case in MS.

-Increased antibodies to many different viruses have been found in the blood and cerebrospinal fluid of people with MS

However, this does not necessarily represent disease-causing infection by these viruses. It is more likely to be the result of non-specific immune activation

TREATMENT AVONEX is inserted as an intramuscular injection It only needs to be taken once a week Helps after the first attack Made of Interferon beta-1a, naturally occurring human protein Reduces the number of flare-ups http://www.avonex.com/msavProject/avonex.portal

AVONEX is inserted as an intramuscular injection

It only needs to be taken once a week

Helps after the first attack

Made of Interferon beta-1a, naturally occurring human protein

Reduces the number of flare-ups

TREATMENT Rebif is inserted subcutaneously (under the skin) It is taken three times a week For patients who relapse Also made from Interferon beta-1a Reduces flare-ups www.Rebif.com

Rebif is inserted subcutaneously (under the skin)

It is taken three times a week

For patients who relapse

Also made from Interferon beta-1a

Reduces flare-ups

TREATMENT Betaseron is inserted subcutaneously Inserted 3-4 times a week Patients who have had a first attack and have MRI signs that correspond to Multiple Sclerosis Includes Interferon beta-1b, a modified human protein Reduces flare-ups http://www.betaseron.com/

Betaseron is inserted subcutaneously

Inserted 3-4 times a week

Patients who have had a first attack and have MRI signs that correspond to Multiple Sclerosis

Includes Interferon beta-1b, a modified human protein

Reduces flare-ups

TREATMENT Copaxone is inserted subcutaneously Taken seven times a week For patients who relapse Made of Glatiramer acetate, a synthetic compound Reduces flare-ups http://www.copaxone.com/

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