Resistant virus may gain the upper hand after a switch to Isentress but may remain under control with continued Kaletra therapy, or continued therapy with another PI boosted by Norvir (ritonavir), such as Aptivus (tipranavir), Invirase (saquinavir), Lexiva (fosamprenavir).

Vertex said it sold the royalty stream from Lexiva and Agenerase, which it licensed to Glaxo, to strengthen its financial position and invest in other programs, particularly its hepatitis C drug programs.

GlaxoSmithKline was also in focus as three of its drugs, Epzicom, Combivir and Lexiva were included in the approved treatment guidelines of the International Aids Society-USA for initial antiretroviral therapy.

On April 29, 2005 GlaxoSmithKline announced that a drug-interaction trial of Lexiva (fosamprenavir) with Nexium (esomeprazole, a proton-pump inhibitor, often used to reduce stomach acidity for relief of reflux, the unwanted flow of stomach acid into the esophagus), had found no reduction in the in the blood level of amprenavir.

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