This paper analyzes the defect of some methods for controlling the ink key of offset printing machine, and presents the advantage of adaptive fuzzy control. Aiming at the problem that the processing curve of offset printing is changed by the environmental impact of production, this paper analyzes this non-real-time measurement and control system with time delay and less test data, and proposes the method of adaptive fuzzy control to amend the control table and adjust the slope of the control curve according to the detection deviations. Finally, the control rules are adjusted to meet the actual situation. By simulating the control arithmetic with the example of the control of printing ink keys under specific conditions using Matlab / Simulink, it is proved to be effective to achieve the expectative effect.