PORTLAND — A 24-year-old Portland man died and two other men were injured Wednesday in an predawn shooting on India Street, the city’s first homicide of 2012 and an apparently random crime of violence.

Matthew Blanchard and three friends had walked downtown from an apartment in North Deering when they encountered two men about 1 a.m.

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Portland Fire Department personnel clean up at the scene of a shooting on India Street this morning that left blood splattered on the sidewalk.

Police closed a section of Congress Street this morning while they investigated the scene of this morning's shooting. This photo is shot from the intersection of Congress and Locust, looking up Munjoy Hill. Photo by Leslie Bridgers / Staff Writer

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Witnesses told police that a loud argument erupted and suddenly several shots were fired.

Blanchard and two of his friends were shot. All three men were taken to Maine Medical Center, where Blanchard was pronounced dead. Police Chief Michael Sauschuck would not describe his injuries.

Joshua Hersom, 24, and John Howard, 20, were treated for injuries that were not life-threatening, Sauschuck said.

A 19-year-old who was with the men was not identified because he is classified as a witnesses, the chief said.

Police converged on the area after the shooting, with two officers coming from the corner of Washington and Cumberland avenues and two from the police station, a couple of blocks away.

Witnesses told police that they saw two men running west on Congress Street. Police believe that one of the two was the gunman, and that he used a handgun.

At a news conference Wednesday afternoon, Sauschuck urged residents who might have seen the men who ran from the shooting to contact investigators at 874-8533 or send a text with the keyword “GOTCHA” to 274637.

On Wednesday morning, drops of blood remained on the sidewalk outside the apartment building at 105-107 India St. Angelina Badalucco, who lives on the second floor, said she woke up to what sounded like firecrackers and gunshots.

She walked to the front of the building and saw a young man, with a bicycle and a backpack next to him and blood on his arm, saying his friend had been shot. Another man was lying in a grassy patch next to the building and looked badly injured, she said.

Badalucco, who has lived in the building for three months, said she had never seen the men.

She said people often hang out in a concrete area in the back of the building, drinking and smoking. “I’m not surprised there was a confrontation and someone happened to have a weapon,” she said.

Blanchard was on a bicycle and his friends were on foot when the altercation broke out in front of 105 India St.

Blanchard’s friends said they did not know their attackers, and police said there is no evidence that the fight involved drugs or was racially motivated.

Neither group appeared to have been at any bars before the confrontation, Sauschuck said.

Police initially described the two men who ran from the scene as black, but witnesses described two men who were in the area right before the shooting as Asian.

“We have limited suspect information at this point,” Sauschuck said.

Police canvassed the area, looking for witnesses and seeking out businesses that might have security video that would show the area at the time of the shooting.

Although there are homes along India Street, much of it consists of businesses. The Milestone Shelter, for people with substance abuse problems, is at 65 India St. Sauschuck said there is no apparent connection between the shelter and the shooting.

Police fanned out into the apartment buildings on nearby Cumberland Avenue and the streets leading into the Kennedy Park public housing development.

“Kennedy Park was targeted to be the general location of where the individuals escaped,” Sauschuck said.

Blanchard was in the news last month in connection with the death of a friend.

On June 22, he fell asleep at the wheel of a 2008 Chevrolet Cobalt and crashed on Gray Road in Falmouth, killing Casey Green, 22, of Cumberland.

There were no signs that he was drinking or speeding in the 50 mph zone.

Blanchard initially told police that he was not driving, but later admitted to being behind the wheel, Falmouth police said.

Police charged Blanchard with causing an accident that led to the death of someone while driving with a suspended license. Police do not believe there is any connection between the crash and Wednesday’s shooting.

The homicide was the first of this year in Portland. Sauschuck said the city averages three a year. It had two in 2011. One of them, which occurred at the corner of outer Congress Street and Massachusetts Avenue, remains unsolved.