The Hallmarks of Aging & Interventions

RevGenetics has been working diligently on addressing different aspects of aging. While others developed their own “Unified theory of aging” based on accumulation of minerals such as Iron and Calcium, we took a different route.

The Hallmarks of Aging & Interventions

Rather than trying to reinvent the wheel or focus on a single aspect of aging, we instead focused on building on the work of scientists like Aubrey De Grey at the SENS Research Foundation who has provided leadership in this space to many scientists. We’ve also studied the work of Maria Blasco who has been on the cutting edge of aging and cancer science.

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In 2013 Maria Blasco, Director and researcher on aging and cancer at the National Cancer Institute in Spain (with over 30 international scientific awards), published with her collaborators an encompassing review on the 9 tentative hallmarks of aging that are found to be common in different organisms, especially in mammals like us. (Study In Cell)

The review has quickly been accepted by much of the scientific community as a landmark paper, and is used as a reference for many students in academia who are pursuing advanced degrees in the field and has been cited over 400 times by other scientific papers. While we will not be delving deeply into the 9 hallmarks, we will provide general information on them. Below, we provide the hallmarks of aging, the interventions, and finally how we have been using our resources to create products to support some of these interventions.

9 Hallmarks of Aging- RevGenetics Line Up

What are the 9 hallmarks of aging?

To be considered as a hallmark of aging experimentally three criteria must be met: fisrt, the hallmark must manifest itself during normal aging, second, worsening of the hallmark leads to accelerated aging, and third, alleviating the hallmark leads to delay in aging and a healthier lifespan. The following hallmarks of aging are described thoroughly in the published scientific paper. You can review the paper in the link we provided above. Here we will simply name them for your reference:

A combination of causative and compensatory hallmarks leads to what is referred to as the “integrative” hallmarks of aging. Integrative hallmarks are viewed as the final culprits that cause a young organism to lose it’s functionality and change its appearance from young to old, essentially, what we call aging.

The 2 “integrative” hallmarks are:

1- Stem cell exhaustion 2- Altered intercellular communication

What are the interventions that may help?

In the published paper, Maria Blasco and her collaborators provided areas of intervention that can be sought by science to help slow the aging process, deal with the present damage found, and prevent ongoing damage. The following areas of interventions are:

What has RevGenetics been doing related to these interventions?

At RevGenetics we are researching and following these strategies to combat aging. Although we can only make supplements we believe we can address and support many of these interventions. Below we provide the interventions and the products we use to support these interventions:

ProxyStem – Stem Cell Support

1- Stem cell based therapies ProxyStem: We provide ProxyStem to support stem cells and maintaning their functionality. Medical therapies are still pretty far off, but we believe they will be available at one point because of the SENS Foundation.

2-Anti-inflammatory drugs, blood borne rejuvenation factors MetaCurcumin: We can’t address the blood borne rejuvenation factors as a supplement company. We believe the upcoming lab we call the “Vampire Lab” will address blood borne rejuvenation factors, but ProxyStem, MetaCurcumin and Resveratrol do address some inflammatory issues in this area.

4- Telomerase reactivation We believe our recommended telomerase activator TA-65 can address this item until an RNA solution is medically tested and found to be safe in humans. Our recommended telomerase activator has been found to be safe in humans, and even provided to some cancer patients by doctors we know.

5- Epigenetic drugs Resveratrol can modulate Sirtuin protein family members, which in turn have been shown to modulate epigenetics target known to affect longevity.

6- Activation of chaperones and proteotic systems We are looking into this, and may provide an update in the future.

MetaCurcumin 200 – Anti-inflammatory

7- Dietary restricition, mTOR inhibition, along with AMPK and Sirtuin activation. Resveratrol, MetaCurcumin and Polymax will help with this item, along with an intermittent 3-5 day fast.

9- Clearance of senescent cells This may be a difficult item, and might only be addressed by specialized drugs, which no supplement maker can provide.

While RevGenetics cannot address every possible intervention through a supplement, we are considering creating a new company to delve more deeply into those items we currently cannot support because of FDA regulations. If you would like to support us, please consider purchasing one of our products on a monthly basis, starting today, thank you.

Copyright 2016 - RevGenetics TA-65. - The site does not provide any medical advice. RevGenetics LLC is a supplement company and is not engaged in rendering medical or professional advice or services. The information provided on our site is not intended to replace any medical advice offered by a health care provider. RevGenetics LLC recommends that you consult a physician or professional health care provider prior to the use of the products advertised on the site. You agree that all posts content and information are opinions and is compiled or arrived at from sources believed to be reliable but no representation or warranty, express or implied, is made as to their accuracy or completeness and no information, opinion or forecast shall be taken as a representation for which RevGenetics LLC or its authors or any of their employees or associates assume any responsibility. By accessing this site you agree that all information is considered a "Fair Comment" or Personal Opinion of the author(s) at RevGenetics LLC.

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