Publications

Geroprotectors.org: a new, structured and curated database of current therapeutic interventions in aging and age-related disease. Aging (Albany NY).

Written and published by Biogerontology Research Foundation staff in collaboration with
the Buck Institute for Research on Aging, George Mason University (School of
Systems Biology), Moscow Institute of Physics and Technology, Engelhardt
Institute of Molecular Biology of Russian Academy of Sciences (Laboratory of
Postgenomic Studies), Institute of Integrative Biology (Integrative Genomics of
Ageing Group). D. Rogachev Center for Pediatric Hematology, Oncology and
Immunology, The Judea Regional R&D Center, Pirogov Russian National
Research Medical University (, The Research Institute for Translational
Medicine ), Insilico Medicine, Inc., Xspansa, University of Tennessee Health
Science Center (Institute of Physiologically Active Compounds of Russian
Academy of Sciences, Genetics, Genomics, and Informatics) and Infinity Sciences,
Inc.

Abstract: As the level of interest in aging
research increases, there is a growing number of geroprotectors, or therapeutic
interventions that aim to extend the healthy lifespan and repair or reduce
aging-related damage in model organisms and, eventually, in humans. There is a
clear need for a manually-curated database of geroprotectors to compile and
index their effects on aging and age-related diseases and link these effects to
relevant studies and multiple biochemical and drug databases. Here, we
introduce the first such resource, Geroprotectors (http://geroprotectors.org).
Geroprotectors is a public, rapidly explorable database that catalogs over 250
experiments involving over 200 known or candidate geroprotectors that extend
lifespan in model organisms. Each compound has a comprehensive profile complete
with biochemistry, mechanisms, and lifespan effects in various model organisms,
along with information ranging from chemical structure, side effects, and
toxicity to FDA drug status. These are presented in a visually intuitive,
efficient framework fit for casual browsing or in-depth research alike. Data
are linked to the source studies or databases, providing quick and convenient
access to original data. The Geroprotectors database facilitates cross-study,
cross-organism, and cross-discipline analysis and saves countless hours of
inefficient literature and web searching. Geroprotectors is a one-stop, knowledge-sharing,
time-saving resource for researchers seeking healthy aging solutions.