Calcium and phosphorus metabolism in patients who have chronic kidney disease

William G GoodmanDivision of Nephrology, Department of Medicine, David Geffen School of Medicine at the University of California at Los Angeles, University of California at Los Angeles Medical Center, CA 90095, USAMed Clin North Am 89:631-47. 2005

..This mechanism of action differs fundamentally from that of the vitamin D sterols, which heretofore have been the only definitive pharmacological intervention for treating secondary hyperparathyroidism...

..Studies using this non-invasive diagnostic method may provide important new information about factors that initiate the development and mediate the progression of arterial calcification in patients with ESRD...

Assays for parathyroid hormone and their use in patients with end-stage renal disease

..The current review summarizes key technical developments in the evolution of PTH assays. We also discuss the diagnostic value of various methods for measuring PTH in serum or plasma for the assessment of patients with renal bone disease...

Calcium and phosphorus metabolism in patients who have chronic kidney disease

William G GoodmanDivision of Nephrology, Department of Medicine, David Geffen School of Medicine at the University of California at Los Angeles, University of California at Los Angeles Medical Center, CA 90095, USAMed Clin North Am 89:631-47. 2005

..Strategies for clinical management are being revised, and recent recommendations differ substantially from those used previously with a renewed emphasis on safety...

..The calcimimetic agent R-568 lowers plasma parathyroid hormone (PTH) levels in hemodialysis patients with mild secondary hyperparathyroidism, but its efficacy in those with more severe secondary hyperparathyroidism has not been studied...

Non-invasive assessments of cardiovascular disease in patients with renal failure

..The consequences of inadequately controlled secondary HPT and the adverse effects of selected therapeutic interventions for the disorder on vascular calcification and cardiovascular disease in those with CKD are discussed...

Similar predictive value of bone turnover using first- and second-generation immunometric PTH assays in pediatric patients treated with peritoneal dialysis

..05. Compared with controls, in patients with high-turnover lesions, CBD was lower ( P<0.0001) and TBD higher ( P<0.0001). These findings suggest that pQCT may be an additional tool in the assessment of renal osteodystrophy...

The flavors of vitamin D: tasting the molecular mechanisms

William G GoodmanKidney Int 66:1286-7. 2004

Comments on plasma parathyroid hormone levels and their relationship to bone histopathology among patients undergoing dialysis

William G GoodmanSemin Dial 20:1-4. 2007

..These matters serve as the focus for the current commentary...

Long-term treatment of secondary hyperparathyroidism with the calcimimetic cinacalcet HCl

..Despite these developments in understanding the etiology of renal failure and the availability of new assays for bioactive PTH, no adequate surrogate for bone biopsy and quantitative bone histomorphometry has been developed...