Indication: WELLBUTRIN XL® (hydrochloride extended-release tablets) is a prescription medicine used to treat
adults with a certain type of depression called major depressive disorder, and for the prevention of autumn-winter seasonal depression (seasonal affective disorder).

PATIENT

HCP

INDICATION

WELLBUTRIN XL® (hydrochloride extended-release tablets) is a prescription medicine used to treat adults with a certain type of depression called
major depressive disorder, and for the prevention of autumn-winter seasonal depression (seasonal affective disorder).

IMPORTANT SAFETY INFORMATION

WARNING: CHANGES IN THINKING AND BEHAVIOR, DEPRESSION, AND SUICIDAL THOUGHTS OR ACTIONS

Suicidal Thoughts or Actions and Antidepressant Drugs

Antidepressants may increase suicidal thoughts or actions in some children, teenagers, or young adults within the first few months of treatment.
Depression or other serious mental illnesses are the most important causes of suicidal thoughts or actions. People who have (or have a family
history of) bipolar illness, or suicidal thoughts or actions may have a particularly high risk. Pay close attention to any changes, especially sudden
changes in mood, behaviors, thoughts, or feelings. Call your healthcare provider right away if symptoms such as anxiety, irritability, impulsivity,
trouble sleeping, aggressive behavior or suicidal thoughts are new, worse or worry you. WELLBUTRIN XL has not been evaluated for use in
patients under the age of 18.

Changes in Thinking and Behavior When Taking Bupropion to Quit Smoking

Although WELLBUTRIN XL is not a treatment for quitting smoking, some people have had changes in behavior, hostility, agitation, depression,
suicidal thoughts or actions while talking bupropion to help them quit smoking. These symptoms can develop during treatment or after stopping
treatment. If symptoms occur such as agitation, hostility, depression or changes in thinking or behavior that are not typical for you, stop taking
bupropion and call your healthcare provider right away.

Call your healthcare provider right away if you or your family member has any of the following symptoms especially if they are new,
worse, or worry you:

thoughts about suicide or dying

attempts to commit suicide

new or worse depression

new or worse anxiety

feeling very agitated or restless

panic attacks

trouble sleeping (insomnia)

new or worse irritability

acting aggressive, being angry, or violent

acting on dangerous impulses

an extreme increase in activity and talking (mania)

other unusual changes in behavior or mood

What Other Important Information Should I Know About WELLBUTRIN XL?

Seizures: There is a chance of having a seizure (convulsion, fit) with WELLBUTRIN XL, especially in people with certain medical
problems or who take certain medicines. Do not take any other medicines while you are taking WELLBUTRIN XL unless your
healthcare provider has said it is okay to take them. If you have a seizure while taking WELLBUTRIN XL, stop taking the tablets and
call your healthcare provider right away.

High blood pressure (hypertension): Some people get high blood pressure, that can be severe, while taking WELLBUTRIN XL.

Manic episodes: Some people may have periods of mania while taking WELLBUTRIN XL. If you have any of the following symptoms of mania,
call your healthcare provider:

greatly increased energy

severe trouble sleeping

racing thoughts

reckless behavior

unusually grand ideas

excessive happiness or irritability

talking more or faster than usual

Unusual thoughts or behaviors: Some patients may have unusual thoughts or behaviors while taking WELLBUTRIN XL, including delusions
(believe you are someone else), hallucinations (seeing or hearing things that are not there), paranoia (feeling that people are against you), or
feeling confused. If this happens to you, call your healthcare provider.

Visual problems: Some people are at risk for the following problems. You may want to undergo an eye examination to see if you are at risk:

eye pain

changes in vision

swelling or redness in or around the eye

Severe allergic reactions: Some patients have severe allergic reactions to WELLBUTRIN XL. Stop taking WELLBUTRIN XL and call your healthcare provider right away
if you get a rash, itching, hives, fever, swollen lymph glands, painful sores in the mouth or around the eyes, swelling of the lips or tongue, chest pain, or have trouble breathing. These could be signs of a serious allergic reaction.

Do not take WELLBUTRIN XL if you:

have or had a seizure disorder or epilepsy.

have or had an eating disorder such as anorexia nervosa or bulimia.

are taking any other medicines that contain bupropion, including ZYBAN (used to help people stop smoking), APLENZIN®,
FORFIVO XL, WELLBUTRIN or WELLBUTRIN SR.
Bupropion is the same active ingredient that is in WELLBUTRIN XL.

drink a lot of alcohol and abruptly stop drinking, or use medicines called sedatives (these make you sleepy) or benzodiazepines, or
anti-seizure medicines, and you stop using them all of a sudden.

take a monoamine oxidase inhibitor (MAOI). Ask your healthcare provider or pharmacist if you are not sure if you take an MAOI, including the
antibiotic linezolid.

do not take an MAOI within 2 weeks of stopping WELLBUTRIN XL unless directed to do
so
by
your healthcare provider.

do not start WELLBUTRIN XL if you stopped taking an MAOI in the last 2 weeks unless directed
to do so by your healthcare provider.

are allergic to the active ingredient in WELLBUTRIN XL, bupropion hydrochloride, or to any of the inactive ingredients.

Before taking Wellbutrin XL tell your healthcare provider if you have ever had depression, suicidal thoughts or actions, or other mental
health problems; and other medical conditions including if you:

have liver problems, especially cirrhosis of the liver.

have kidney problems.

have, or have had, an eating disorder such as anorexia nervosa or bulimia.

have had a head injury.

have had a seizure (convulsion, fit).

have a tumor in your nervous system (brain or spine).

have had a heart attack, heart problems, or high blood pressure.

are a diabetic taking insulin or other medicines to control your blood sugar.

drink alcohol.

abuse prescription medicines or street drugs.

are pregnant or plan to become pregnant.

are breastfeeding. WELLBUTRIN XL passes into your milk in small amounts.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal
supplements. Many medicines increase your chances of having seizures or cause other serious side effects if you take them while you are
using WELLBUTRIN XL.

INDICATION

WELLBUTRIN XL® (hydrochloride extended-release tablets) is a prescription medicine used to treat adults with a certain type of depression
called major depressive disorder, and for the prevention of autumn-winter seasonal depression (seasonal affective disorder).

IMPORTANT SAFETY INFORMATION

WARNING: CHANGES IN THINKING AND BEHAVIOR, DEPRESSION, AND SUICIDAL THOUGHTS OR ACTIONS

Suicidal Thoughts or Actions and Antidepressant Drugs
Antidepressants may increase suicidal thoughts or actions in some children, teenagers, or young adults within the first few months of treatment.
Depression or other serious mental illnesses are the most important causes of suicidal thoughts or actions. People who have (or have a family
history of) bipolar illness, or suicidal thoughts or actions may have a particularly high risk. Pay close attention to any changes, especially sudden
changes in mood, behaviors, thoughts, or feelings. Call your healthcare provider right away if symptoms such as anxiety, irritability, impulsivity,
trouble sleeping, aggressive behavior or suicidal thoughts are new, worse or worry you. WELLBUTRIN XL has not been evaluated for use in
patients under the age of 18.

Changes in Thinking and Behavior When Taking Bupropion to Quit Smoking
Although WELLBUTRIN XL is not a treatment for quitting smoking, some people have had changes in behavior, hostility, agitation, depression,
suicidal thoughts or actions while talking bupropion to help them quit smoking. These symptoms can develop during treatment or after stopping
treatment. If symptoms occur such as agitation, hostility, depression or changes in thinking or behavior that are not typical for you, stop taking
bupropion and call your healthcare provider right away.

Call your healthcare provider right away if you or your family member has any of the following symptoms especially if they are new,
worse, or worry you:

thoughts about suicide or dying

attempts to commit suicide

new or worse depression

new or worse anxiety

feeling very agitated or restless

panic attacks

trouble sleeping (insomnia)

new or worse irritability

acting aggressive, being angry, or violent

acting on dangerous impulses

an extreme increase in activity and talking (mania)

other unusual changes in behavior or mood

What Other Important Information Should I Know About WELLBUTRIN XL?

Seizures: There is a chance of having a seizure (convulsion, fit) with WELLBUTRIN XL, especially in people with certain medical
problems or who take certain medicines. Do not take any other medicines while you are taking WELLBUTRIN XL unless your
healthcare provider has said it is okay to take them. If you have a seizure while taking WELLBUTRIN XL, stop taking the tablets and
call your healthcare provider right away.

High blood pressure (hypertension): Some people get high blood pressure, that can be severe, while taking WELLBUTRIN XL.

Manic episodes: Some people may have periods of mania while taking WELLBUTRIN XL. If you have any of the following symptoms of mania,
call your healthcare provider:

greatly increased energy

severe trouble sleeping

racing thoughts

reckless behavior

unusually grand ideas

excessive happiness or irritability

talking more or faster than usual

Unusual thoughts or behaviors: Some patients may have unusual thoughts or behaviors while taking WELLBUTRIN XL, including delusions
(believe you are someone else), hallucinations (seeing or hearing things that are not there), paranoia (feeling that people are against you), or
feeling confused. If this happens to you, call your healthcare provider.

Visual problems: Some people are at risk for the following problems. You may want to undergo an eye examination to see if you are at risk:

eye pain

changes in vision

swelling or redness in or around the eye

Severe allergic reactions: Some patients have severe allergic reactions to WELLBUTRIN XL. Stop taking WELLBUTRIN XL and call
your healthcare provider right away
if you get a rash, itching, hives, fever, swollen lymph glands, painful sores in the mouth or around the
eyes, swelling of the lips or tongue, chest pain, or have trouble breathing. These could be signs of a serious allergic reaction.

Do not take WELLBUTRIN XL if you:

have or had a seizure disorder or epilepsy.

have or had an eating disorder such as anorexia nervosa or bulimia.

are taking any other medicines that contain bupropion, including ZYBAN (used to help people stop smoking), APLENZIN®,
FORFIVO XL, WELLBUTRIN or WELLBUTRIN SR.
Bupropion is the same active ingredient that is in WELLBUTRIN XL.

drink a lot of alcohol and abruptly stop drinking, or use medicines called sedatives (these make you sleepy) or benzodiazepines, or
anti-seizure medicines, and you stop using them all of a sudden.

take a monoamine oxidase inhibitor (MAOI). Ask your healthcare provider or pharmacist if you are not sure if you take an MAOI, including the
antibiotic linezolid.

do not take an MAOI within 2 weeks of stopping WELLBUTRIN XL unless directed to do so by
your healthcare provider.

do not start WELLBUTRIN XL if you stopped taking an MAOI in the last 2 weeks unless directed
to do so by your healthcare provider.

are allergic to the active ingredient in WELLBUTRIN XL, bupropion hydrochloride, or to any of the inactive ingredients.

Before taking Wellbutrin XL tell your healthcare provider if you have ever had depression, suicidal thoughts or actions, or other mental
health problems; and other medical conditions including if you:

have liver problems, especially cirrhosis of the liver.

have kidney problems.

have, or have had, an eating disorder such as anorexia nervosa or bulimia.

have had a head injury.

have had a seizure (convulsion, fit).

have a tumor in your nervous system (brain or spine).

have had a heart attack, heart problems, or high blood pressure.

are a diabetic taking insulin or other medicines to control your blood sugar.

drink alcohol.

abuse prescription medicines or street drugs.

are pregnant or plan to become pregnant.

are breastfeeding. WELLBUTRIN XL passes into your milk in small amounts.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal
supplements. Many medicines increase your chances of having seizures or cause other serious side effects if you take them while you are
using WELLBUTRIN XL.

INDICATION

WELLBUTRIN XL® (hydrochloride extended-release tablets) is a prescription medicine used to treat adults with a certain type of depression
called major depressive disorder, and for the prevention of autumn-winter seasonal depression (seasonal affective disorder).

IMPORTANT SAFETY INFORMATION

WARNING: CHANGES IN THINKING AND BEHAVIOR, DEPRESSION, AND SUICIDAL THOUGHTS OR ACTIONS

Suicidal Thoughts or Actions and Antidepressant Drugs

Antidepressants may increase suicidal thoughts or actions in some children, teenagers, or young adults within the first few months of treatment.
Depression or other serious mental illnesses are the most important causes of suicidal thoughts or actions. People who have (or have a family
history of) bipolar illness, or suicidal thoughts or actions may have a particularly high risk. Pay close attention to any changes, especially sudden
changes in mood, behaviors, thoughts, or feelings. Call your healthcare provider right away if symptoms such as anxiety, irritability, impulsivity,
trouble sleeping, aggressive behavior or suicidal thoughts are new, worse or worry you. WELLBUTRIN XL has not been evaluated for use in
patients under the age of 18.

Changes in Thinking and Behavior When Taking Bupropion to Quit Smoking

Although WELLBUTRIN XL is not a treatment for quitting smoking, some people have had changes in behavior, hostility, agitation, depression,
suicidal thoughts or actions while talking bupropion to help them quit smoking. These symptoms can develop during treatment or after stopping
treatment. If symptoms occur such as agitation, hostility, depression or changes in thinking or behavior that are not typical for you, stop taking
bupropion and call your healthcare provider right away.

Call your healthcare provider right away if you or your family member has any of the following symptoms especially if they are new,
worse, or worry you:

thoughts about suicide or dying

attempts to commit suicide

new or worse depression

new or worse anxiety

feeling very agitated or restless

panic attacks

trouble sleeping (insomnia)

new or worse irritability

acting aggressive, being angry, or violent

acting on dangerous impulses

an extreme increase in activity and talking (mania)

other unusual changes in behavior or mood

What Other Important Information Should I Know About WELLBUTRIN XL?

Seizures: There is a chance of having a seizure (convulsion, fit) with WELLBUTRIN XL, especially in people with certain medical
problems or who take certain medicines. Do not take any other medicines while you are taking WELLBUTRIN XL unless your
healthcare provider has said it is okay to take them. If you have a seizure while taking WELLBUTRIN XL, stop taking the tablets and
call your healthcare provider right away.

High blood pressure (hypertension): Some people get high blood pressure, that can be severe, while taking WELLBUTRIN XL.

Manic episodes: Some people may have periods of mania while taking WELLBUTRIN XL. If you have any of the following symptoms of mania,
call your healthcare provider:

greatly increased energy

severe trouble sleeping

racing thoughts

reckless behavior

unusually grand ideas

excessive happiness or irritability

talking more or faster than usual

Unusual thoughts or behaviors: Some patients may have unusual thoughts or behaviors while taking WELLBUTRIN XL, including delusions
(believe you are someone else), hallucinations (seeing or hearing things that are not there), paranoia (feeling that people are against you), or
feeling confused. If this happens to you, call your healthcare provider.

Visual problems: Some people are at risk for the following problems. You may want to undergo an eye examination to see if you are at risk:

eye pain

changes in vision

swelling or redness in or around the eye

Severe allergic reactions: Some patients have severe allergic reactions to WELLBUTRIN XL. Stop taking WELLBUTRIN XL and call
your healthcare provider right away
if you get a rash, itching, hives, fever, swollen lymph glands, painful sores in the mouth or around the
eyes, swelling of the lips or tongue, chest pain, or have trouble breathing. These could be signs of a serious allergic reaction.

Do not take WELLBUTRIN XL if you:

have or had a seizure disorder or epilepsy.

have or had an eating disorder such as anorexia nervosa or bulimia.

are taking any other medicines that contain bupropion, including ZYBAN (used to help people stop smoking), APLENZIN®,
FORFIVO XL, WELLBUTRIN or WELLBUTRIN SR.
Bupropion is the same active ingredient that is in WELLBUTRIN XL.

drink a lot of alcohol and abruptly stop drinking, or use medicines called sedatives (these make you sleepy) or benzodiazepines, or
anti-seizure medicines, and you stop using them all of a sudden.

take a monoamine oxidase inhibitor (MAOI). Ask your healthcare provider or pharmacist if you are not sure if you take an MAOI, including the
antibiotic linezolid.

do not take an MAOI within 2 weeks of stopping WELLBUTRIN XL unless directed to do so by
your healthcare provider.

do not start WELLBUTRIN XL if you stopped taking an MAOI in the last 2 weeks unless directed
to do so by your healthcare provider.

are allergic to the active ingredient in WELLBUTRIN XL, bupropion hydrochloride, or to any of the inactive ingredients.

Before taking Wellbutrin XL tell your healthcare provider if you have ever had depression, suicidal thoughts or actions, or other mental
health problems; and other medical conditions including if you:

have liver problems, especially cirrhosis of the liver.

have kidney problems.

have, or have had, an eating disorder such as anorexia nervosa or bulimia.

have had a head injury.

have had a seizure (convulsion, fit).

have a tumor in your nervous system (brain or spine).

have had a heart attack, heart problems, or high blood pressure.

are a diabetic taking insulin or other medicines to control your blood sugar.

drink alcohol.

abuse prescription medicines or street drugs.

are pregnant or plan to become pregnant.

are breastfeeding. WELLBUTRIN XL passes into your milk in small amounts.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal
supplements. Many medicines increase your chances of having seizures or cause other serious side effects if you take them while you are
using WELLBUTRIN XL.