Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The peptide neurotransmittersubstance P modulates sensitivity to pain by activating the neurokinin-1 (NK-1) receptor, which is expressed by discrete populations of neurons throughout the central nervous system.

On the other hand, there were no significant differences in NK1-like immunoreactivity, [(3)H]substance P binding, or NK1 gene expression in the dorsal horn of the spinal cord between NOP(-/-) and NOP(+/+) mice.

To test the hypothesis that NK-1 geneexpression underlies these responses, we used solution hybridization-nuclease protection assays to quantify NK-1 mRNA levels in dorsal quadrants of the mouse lumbar dorsal horn.

To identify the areas of the brain that might contribute to this effect, we assessed the behavioral effects of ablation of neuronsexpressing the NK1 receptor in specific regions of the mouse brain using the neurotoxin substance P-saporin.

We examined PPE and PPT (preprotachykinin) gene expression in striatal projection neurons and in striatal projection fibers immunoreactive for the PPE product enkephalin (ENK) and the PPT product substance P (SP) in a transgenicHD model, the R6/2 mouse, to see if changes occur in these neuron types similar to those seen in early adult-onset HD.

The dendritic geometry and synaptic input of the large LI neurones that receive input from primary afferents containing substance P that expressneurokinin 1 (NK(1)) receptors suggests that these neurones may monitor the extent of injury rather than the specific localisation of a discrete noxious stimulus.

The importance of NK-1 signaling and TRPV1 expressing afferent nerves for disease development was studied in recipient SCID mice systemically treated with either high-affinity NK-1 receptor antagonists or neurotoxic doses of capsaicin.

The peptide neurotransmittersubstance P modulates sensitivity to pain by activating the neurokinin-1 (NK-1) receptor, which is expressed by discrete populations of neurons throughout the central nervous system.