The separate influence of topographical and chemical cues on cell attachment and spreading are well documented; however, that of duel-cue substrates is less so. In this study graft copolymers that sterically stabilize biological surfaces were employed alongside nanotopographical features fabricated by colloidal lithography. This resulted in the production of a range of substrates whereby the effect of chemistry and or topography on both on human fibroblast and bone marrow cell adhesion and spreading could be observed. The current studies indicate an enhancement of cell response as a consequence of modifications in material topography, whereas the current selected chemical cues inhibited cell function. Critically, in combination, topography modulated the effects of chemical environment.

BibTeX @article{Berry2007,author={Berry, C C and Curtis, A S G and Oreffo, R O C and Agheli, Hossein and Sutherland, D S},title={Human fibroblast and human bone marrow cell response to lithographically nanopatterned adhesive domains on protein rejecting substrates.},journal={IEEE transactions on nanobioscience},issn={1536-1241},volume={6},issue={3},pages={201-9},abstract={The separate influence of topographical and chemical cues on cell attachment and spreading are well documented; however, that of duel-cue substrates is less so. In this study graft copolymers that sterically stabilize biological surfaces were employed alongside nanotopographical features fabricated by colloidal lithography. This resulted in the production of a range of substrates whereby the effect of chemistry and or topography on both on human fibroblast and bone marrow cell adhesion and spreading could be observed. The current studies indicate an enhancement of cell response as a consequence of modifications in material topography, whereas the current selected chemical cues inhibited cell function. Critically, in combination, topography modulated the effects of chemical environment.},year={2007},keywords={Biocompatible Materials, chemistry, Bone Marrow Cells, cytology, metabolism, Cell Adhesion, physiology, Cell Culture Techniques, methods, Cell Proliferation, Cell Survival, Cells, Cultured, Fibroblasts, cytology, metabolism, Humans, Materials Testing, Nanostructures, chemistry, ultrastructure, Proteins, chemistry, metabolism, Substrate Specificity, Surface Properties, Tissue Engineering, methods},}

RefWorks RT Journal ArticleSR ElectronicID 174101A1 Berry, C CA1 Curtis, A S GA1 Oreffo, R O CA1 Agheli, HosseinA1 Sutherland, D ST1 Human fibroblast and human bone marrow cell response to lithographically nanopatterned adhesive domains on protein rejecting substrates.YR 2007JF IEEE transactions on nanobioscienceSN 1536-1241VO 6IS 3SP 201OP 9AB The separate influence of topographical and chemical cues on cell attachment and spreading are well documented; however, that of duel-cue substrates is less so. In this study graft copolymers that sterically stabilize biological surfaces were employed alongside nanotopographical features fabricated by colloidal lithography. This resulted in the production of a range of substrates whereby the effect of chemistry and or topography on both on human fibroblast and bone marrow cell adhesion and spreading could be observed. The current studies indicate an enhancement of cell response as a consequence of modifications in material topography, whereas the current selected chemical cues inhibited cell function. Critically, in combination, topography modulated the effects of chemical environment.LA engPMID 17926777LK http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17926777OL 30