Night shift workers likelier to have Type 2 diabetes

The results showed that peak glucose levels were 16 percent higher during one night of simulated shift work, compared with one day of a simulated daytime work schedule.

Compared with the daytime protocol, insulin levels during the night shift protocol were 40 to 50 percent higher at 80 minutes and 90 minutes after a meal.

Lead author Christopher Morris, PhD, postdoctoral research fellow in the Medical Chronobiology Program of the Division of Sleep Medicine at Brigham and Women’s Hospital and Harvard Medical School in Boston, Massachusetts, said that it is surprising that a single night shift can significantly impair glucose tolerance and increase insulin levels.

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The study group comprised 13 healthy, non-obese adults without significant shift work history, who completed two, eight-day, in-laboratory protocols in random order, one including day work and the other night work.

Each condition included four baseline days, followed by either day or night shifts.

The diet was isocaloric, identical between conditions, and included standardized mixed meals on Days 1 and 3 of day/night work to assess serum glucose and insulin responses. Subjects began eating at 8 a.m. (day work) or 8 p.m. (night work) and were required to finish eating in 20 minutes.

A fasting blood sample was taken before the meal, and then additional blood samples were drawn every 10 minutes for 90 minutes, then every 30 minutes for 90 minutes. Only results pertaining to mixed meals consumed on Day 1 of day work and night work were included in the current analysis.

According to the authors, about 8.6 million citizens of the US regularly perform night work, which is associated with Type 2 diabetes risk in epidemiologic studies.

The research has been published in an online supplement of the journal Sleep.