This paper identifies key issues in service trade from value chain and value co-creation perspectives. In particular, the authors elaborate how to integrate with modes of service trade and suppliers value co-creation strategies for the healthcare sector through two cases from the real world. Their findings suggest that a firm should first deploy the industry value chain it belongs to when it wants to penetrate foreign markets. A firm may then identify the needs of the target customers (including both domestic service providers and receivers) through value co-creation. Finally, by taking into account the features of the industry value chain, a firm can determine the most appropriate mode (and the corresponding routes if necessary) for service trade by following the General Agreement on Trade in Services (GATS) framework.