Acetohexamide[?] - A pill taken to lower the level of glucose (sugar) in the blood. Only some people with Type II diabetes take these pills. See also: Oral hypoglycemic agents. One of the sulfuonylurea drugs.

Acidosis[?] - An acidic condition in the blood. If prolonged, or severe, it can cause coma and death. For a person with diabetes, this can be caused by insufficient glucose absorption (eg, from inadequate insulin) and metabolic ketosis. It can lead to diabetic ketoacidosis. A medical emergency. See also: Diabetic ketoacidosis.

Acute - Happens for a limited period of time; abrupt onset; sharp, severe.

Alpha cell[?] - a type of cell in the pancreas (in areas called the islets of Langerhans). Alpha cells make and release a hormone called glucagon, which raises the level of glucose (sugar) in the blood. The name is different in the UK.

Antidiabetic agent[?] - A kind of medication that helps a person with diabetes control the level of glucose (sugar) in the blood so that the body works as it should. See also: Insulin; oral hypoglycemic agents.

Antigens[?] - Substances that cause an immune response in the body. The body "sees" the antigens as harmful or foreign. To fight them, the body produces antibodies, which attack and try to eliminate the antigens.

Artificial pancreas[?] - A large machine used in hospitals that constantly measures glucose (sugar) in the blood and, in response, releases the right amount of insulin. Scientists are also working to develop a small unit that could be implanted in the body, functioning like a real pancreas.

Autonomic neuropathy - A disease of the nerves non-voluntary, non-sensory nervous system affecting mostly the internal organs such as the bladder muscles, the cardiovascular system, the digestive tract, and the genital organs.

Basal rate - Refers to a continuous supply of something. In the case of diabetes, it refers to low levels of insulin needed for such purposes as controlling cellular amino acid uptake, potassium uptake, etc.

Blood urea nitrogen[?] (BUN) A measurement of a metabolic waste product in the blood. Urea is one end product of protein metabolism. Increased levels of BUN in the blood may indicate early kidney damage.

Certified diabetes educator[?] (C.D.E.) - A health care professional who is qualified by the American Association of Diabetes Educators to teach people with diabetes how to manage their condition. The health care team for diabetes should ideally include a diabetes educator, preferably a C.D.E.

C-peptide[?] - A substance that the pancreas releases into the bloodstream in equal amounts to insulin. A test of C-peptide levels will show how much insulin the body is making. Insulin is prepared as two insulin molecules linked by a c-peptide. When insulin is secreted, C-peptide is released as well.

Callus - A small area of skin, usually on the foot, that has become thick and hard from rubbing or pressure. Calluses may lead to other problems such as serious infection. Shoes that fit well can keep calluses from forming. See also: Foot care.

Chlorpropamide[?] - A pill taken to lower the level of glucose (sugar) in the blood. Only some people with noninsulin-dependent diabetes take these pills. See also: Oral hypoglycemic agents One of the sulfonylureas.

Clinical trial - A study carried out in people to answer a question such as whether a new treatment (or drug or exercise technique) is effective or safe. In the US, studies are broken into Phase I, Phase II, and Phase III trials. A properly designed study is carefuly controlled and designed to produce reliable information. A poorly designed study (and there are many of these) does not produce reliable information.

Complications of diabetes[?] - Harmful effects that may happen when a person has diabetes. Some acute effects, such as hypoglycemia or hyperglycemia, can happen any time. Others develop when a person has had diabetes for a long time (years, or even decades). These include damage to the retina of the eye (retinopathy), the blood vessels (angiopathy), the nervous system (neuropathy), and the kidneys (nephropathy). Studies very clearly show that keeping blood glucose levels as close to the normal, nondiabetic range as possible does help prevent, slow, or delay the long term complications of diabetes (eye, kidney, blood vessel, and nerve damage).

Controlled disease[?] - Taking care of oneself so that a disease has less of an effect on the body. People with diabetes can "control" the disease by staying on their diets, by exercising, by taking medicine if it is needed, and by monitoring their blood glucose. This care will help keep the glucose (sugar) level in the blood from becoming either too high or too low.

Conventional therapy[?] - A system of diabetes management practiced by most people with diabetes; the system consists of one or two insulin injections each day, daily self-monitoring of blood glucose, and a standard program of nutrition and exercise. The main objective in this form of treatment is to avoid very high and very low blood glucose (sugar). Contrast close control therapy. Also called: "Standard Therapy." See complications of diabetes.

Coxsackie B4 virus - A virus which can trigger an auto-immune reaction which results in an attack on the beta cells. If destroyed, the person becomes a Type I diabetic, no longer producing insulin internally. *Creatinine

Dawn phenomenon[?] - A sudden rise in blood glucose levels in the early morning hours. This condition sometimes occurs in people with insulin-dependent diabetes and (rarely) in people with noninsulin-dependent diabetes. Unlike the Somogyi effect, it is not a result of an insulin reaction. People who have high levels of blood glucose in the mornings before eating may need to monitor their blood glucose during the night. If blood glucose levels are rising, adjustments in evening snacks or insulin dosages may be recommended. See also: Somogyi effect.

Delta cell[?] - A type of cell in the pancreas in areas called the islets of Langerhans. Delta cells make somatostatin, a hormone that is believed to control how the beta cells make and release insulin and how the alpha cells make and release glucagon.

Desensitization - A method to reduce or stop an allergic reaction to something.

Diabetes control and complications trial[?] (DCCT) - A 10-year study (1983-1993) funded by the National Institute of Diabetes and Digestive and Kidney Diseases to assess the effects of intensive therapy on the long-term complications of diabetes. The study very clearly showed that intensive management (close control) of insulin-dependent diabetes prevents or slows the development of the long-term complicatons of diabetes (eye, kidney, and nerve damage caused by diabetes).

Dietitian[?] - An expert in nutrition who helps people with special health needs plan the kinds and amounts of foods to eat. A registered dietitian (R.D.) has special training and experience. The health care team for diabetes should ideally include a dietitian, preferably an R.D.

Dilated pupil examination[?] - A necessary part of an examination for diabetic eye disease. Special drops are used to enlarge the pupils, enabling the doctor to view the back of the eye for damage.

Emergency medical identification[?] - Cards, bracelets, or necklaces with a written message used by people with diabetes or other medical problems to alert others in case of a medical emergency such as coma.

Endogenous[?] - Grown or made inside the body. Insulin made by a person's own pancreas is endogenous insulin. Insulin that is supplied from outside the body (ie, injected or otherwise supplied) is exogenous.

End-stage renal disease[?] (ESRD) - The final phase of many kidney diseases; treated by dialysis or kidney transplantation. See also: Dialysis; nephropathy.

Exchange lists[?] - A grouping of foods by type to help people on special diets stay on the diet. Each group lists food in serving sizes. A person can exchange, trade, or substitute a food serving in one group for another food serving in the same group. The lists put foods in six groups: (1) starch/bread, (2) meat, (3) vegetables, (4) fruit, (5) milk, and (6) fats. Within a food group, each serving has about the same amount of carbohydrate, protein, fat, and calories.

Exogenous[?] - Grown or made outside the body; for instance, insulin made from pork or beef pancreas is exogenous insulin for people. Contrast endogenous.

Fasting blood glucose test[?] - A method for finding out how much glucose (sugar) is in the blood, unaffected by recent food. The test can show if a person has diabetes (a single reading of 126 mg/dl is diagnostic except in newborns or pregnant women or in some unusual other conditions). A blood sample is often taken in a lab or doctor's office. The test is usually done in the morning before the person has eaten. The normal, nondiabetic range for blood glucose is approx between 70 to 110 mg/dl, depending on the person and whether the blood is from a vein or a capillary, and depending on how the measurement is made (on whole blook or just the plasma).

Foot care[?] - Taking special steps to avoid foot problems such as sores, cuts, bunions, and calluses. Good care includes daily examination of the feet, toes, and toenails and choosing shoes and socks or stockings that fit well. People with diabetes have to take special care of their feet because nerve damage and reduced blood flow sometimes mean they will have less feeling in their feet than normal. They may not notice cuts and other problems as soon as they should. They will also heal less well than others.

Fractional urine[?] - Urine that a person collects for a certain period of time during 24 hours; usually from breakfast to lunch, from lunch to supper, from supper to bedtime, and from bedtime to rising. Also called "block urine."

Funduscopy[?] - A test to look at the back area of the eye to see if there is any damage to the vessels that bring blood to the retina. The doctor uses a device called an ophthalmoscope to check the eye.

Gangrene - Infection of dead body tissue. It is most often caused by a loss of blood flow, especially in the legs and feet.

Gastroparesis[?] - A form of nerve damage that affects the stomach and intestines. Food is not digested properly and does not move through in a normal way, resulting in vomiting, nausea, or bloating. It often interferes with diabetes management. See also: Autonomic neuropathy.

Gestational diabetes mellitus[?] (GDM) - A type of diabetes mellitus that can occur when a woman is pregnant. During the pregnancy (usually later in it), the woman may have glucose (sugar) in her blood at a higher than normal level. However, when the pregnancy ends, the blood glucose levels return to normal in about 95 percent of all cases. It must be treated carefully by a physician for it is dangerous to both mother and child. If treated properly, there are usually no lasting effects on either.

Glomeruli[?] - Network of tiny blood vessels in the kidneys where the blood is filtered and waste products are removed.

Glucagon - A hormone that raises the level of glucose (sugar) in the blood by forcing the liver to release its intracellular stores of glucose. *Glucose

Glucose tolerance test[?] - A test to see if a person has diabetes. The test is usually given in a lab or doctor's office in the morning before the person has eaten. A first sample of blood is taken from the person. Then the person drinks a liquid that has a measured amount of glucose in it. After one hour, a second blood sample is drawn, and, after another hour, a third sample is taken. The object is to see how well the body deals with the glucose in the blood over time without interference from other foods. Depending on the local lab, the number and spacing of samples may vary.

Glycemic index[?] - The effect of different foods on blood glucose (sugar) levels over a period of time. Researchers have discovered that some kinds of foods may raise blood glucose levels more quickly than other foods containing the same amount of carbohydrates. cooked carrots are get glucose in the blood faster than pure glucose! In practice, foods are not eaten alone and the presence of other foods changes the measured results for the pure food. In addition, some foods don't have much carbohydrate even if they get it into the blood quickly. A better guide is glycemic density which combines the glycemic index with the amount of carbohydrate in the food.

Glycogen - A substance made from multiple glucose molecules. Sometimes called 'animal starch'. It is stored in liver and muscle cells and can be converted to glucose if needed.

Glycogenesis[?] (or glucogenesis) The process by which glycogen is formed from glucose. Controlled by insulin. See also: Glycogen.

Glycosylated hemoglobin test[?] - A blood test that measures a the level of a particular variety of hemoglobin (Hb1Ac) which is itself a measure of a person's average blood glucose level for the 3-month period before the test. See: Hemoglobin A1C.

Hemodialysis[?] - A mechanical method of cleaning the blood for people who have kidney disease. See also: Dialysis.

Hemoglobin A1C[?] (HbA1C) - Hemoglobin is the substance in red blood cells that carries oxygen to the cells. Some subtypes react with blood glucose; the HB1Ac type reacts permanently with glucose. Since blood cells live about 90 days or so, the amount of HB1Ac present at any time is a record of how much glucose there has been in that period.

Hyperinsulinism[?] - Too high a level of insulin in the blood. This term most often refers to a condition in which the body produces too much insulin. Researchers believe that this condition may play a role in the development of noninsulin-dependent diabetes and in hypertension. See also: Syndrome X.

Hyperlipidemia[?] - Too high a level of fats (lipids) in the blood. See also: Syndrome X.

Hyperosmolar coma[?] - A coma (loss of consciousness) related to high levels of glucose (sugar) in the blood and requiring emergency treatment. A person with this condition is usually older and weak from loss of body fluids and weight. The person may or may not have a previous history of diabetes. Ketones (acids) are not present in the urine.

Hypotension[?] - Low blood pressure or a sudden drop in blood pressure. A person rising quickly from a sitting or reclining position may have a sudden fall in blood pressure, causing dizziness or fainting.

Immunosuppressive drugs - Drugs that block the body's ability to fight infection or foreign substances that enter the body. A person receiving a kidney or pancreas transplant is given these drugs to stop the body from rejecting the new organ or tissue. Cyclosporin is a commonly used immunosuppressive drug.

Impaired glucose tolerance[?] (IGT) - Blood glucose (sugar) levels higher than normal but not high enough to be called diabetes. People with IGT may or may not develop diabetes. Other names (no longer used) for IGT are "borderline," "subclinical," "chemical," or "latent" diabetes.

Implantable insulin pump[?] - A small pump placed inside of the body that delivers insulin in response to commands from a hand-held device called a programmer.

Insulin allergy[?] - When a person's body has an allergic or bad reaction to taking insulin made from pork or beef or from bacteria, or because the insulin is not exactly the same as human insulin or because it has impurities. The allergy can be of two forms. Sometimes an area of skin becomes red and itchy around the place where the insulin is injected. This is called a local allergy. In another form, a person's whole body can have a bad reaction This is called a systemic allergy. The person can have hives or red patches all over the body or may feel changes in the heart rate and in the rate of breathing. A doctor may treat this allergy by prescribing purified insulins or by desensitization. See also: Desensitization.

Insulin antagonist[?] - Something that opposes or fights the action of insulin. Insulin lowers the level of glucose (sugar) in the blood, whereas glucagon raises it; therefore, glucagon is an antagonist of insulin.

Insulin binding[?] - When insulin attaches itself to something else. This can occur in two ways. First, when a cell needs energy, insulin can bind with the outer part of the cell. The cell then can bring glucose (sugar) inside and use it for energy. With the help of insulin, the cell can do its work very well and very quickly. But sometimes the body acts against itself. In this second case, the insulin binds with the proteins that are supposed to protect the body from outside substances (antibodies). If the insulin is an injected form of insulin and not made by the body, the body sees the insulin as an outside or "foreign" substance. When the injected insulin binds with the antibodies, it does not work as well as when it binds directly to the cell.

Insulin-dependent diabetes mellitus[?] (IDDM) - A chronic condition in which the pancreas makes little or no insulin because the beta cells have been destroyed. The body is then not able to use the glucose (blood sugar) for energy. IDDM usually comes on abruptly, although the damage to the beta cells may begin much earlier. The signs of IDDM are a great thirst, hunger, a need to urinate often, and loss of weight. To treat the disease, the person must inject insulin, follow a diet plan, exercise daily, and test blood glucose several times a day. IDDM usually occurs in children and adults who are under age 30. This type of diabetes used to be known as "juvenile diabetes," "juvenile-onset diabetes," and "ketosis-prone diabetes." It is also called type I diabetes mellitus.

Insulin-induced atrophy[?] - Small dents that form on the skin when a person keeps injecting a needle in the same spot. They are harmless. See also: Lipoatrophy; injection site rotation.

Insulin-induced hypertrophy[?] - Small lumps that form under the skin when a person keeps injecting a needle in the same spot. See also: Lipodystrophy; injection site rotation.

Insulin pen[?] - An insulin injection device the size of a pen that includes a needle and holds a vial of insulin. It can be used instead of syringes for giving insulin injections.

Insulin reaction[?] - Too low a level of glucose (sugar) in the blood; also called hypoglycemia. This occurs when a person with diabetes has injected too much insulin, eaten too little food, or exercised without extra food. The person may feel hungry, nauseated, weak, nervous, shaky, confused, and sweaty. Taking small amounts of sugar, sweet juice, or food with sugar will usually help the person feel better within 10-15 minutes. See also: Hypoglycemia; insulin shock.

Insulin receptors[?] - Areas on the outer part of a cell that allow the cell to join or bind with insulin that is in the blood. When the cell and insulin bind together, the cell can take glucose (sugar) from the blood and use it for energy.

Insulin shock[?] - A severe condition that occurs when the level of blood glucose (sugar) drops quickly. The signs are shaking, sweating, dizziness, double vision, convulsions, and collapse. Insulin shock may occur when an insulin reaction is not treated quickly enough. See also: Hypoglycemia; insulin reaction.

Insulinoma[?] - A tumor of the beta cells in areas of the pancreas called the islets of Langerhans. Although not usually cancerous, such tumors may cause the body to make extra insulin and may lead to a blood glucose (sugar) level that is too low.

Intermittent claudication[?] - Pain in the muscles of the leg that occurs off and on, usually while walking or exercising, and results in lameness (claudication). The pain results from a narrowing of the blood vessels feeding the muscle. Drugs are available to treat this condition.

Islet cell Transplantation[?] - Moving the beta (islet) cells from a donor pancreas and putting them into a person whose pancreas has stopped producing insulin. The beta cells make the insulin that the body needs to use glucose (sugar) for energy. Although transplanting islet cells may one day help people with diabetes, the procedure is still in the research stage.

Islets of Langerhans - Special groups of cells in the pancreas. They make and secrete hormones that help the body break down and use food. Named after Paul Langerhans, the German scientist who discovered them in 1869, these cells sit in clusters in the pancreas. There are five types of cells in an islet: beta cells, which make insulin; alpha cells, which make glucagon; delta cells, which make somatostaton; and PP cells and D1 cells, about which little is known.

Kidney disease[?] - Any one of several chronic conditions that are caused by damage to the cells of the kidney. People who have had diabetes for a long time may have kidney damage. Also called nephropathy.

Kidney threshold[?] - The point at which the blood is holding too much of a substance such as glucose (sugar) and the kidneys "spill" the excess sugar into the urine. See also: Renal threshold.

Kussmaul breathing[?] - The rapid, deep, and labored breathing of people who have ketoacidosis or who are in a diabetic coma. Kussmaul breathing is named for Adolph Kussmaul, the 19th century German doctor who first noted it. Also called "air hunger."

Lancet[?] - A fine, sharp-pointed blade or needle for pricking the skin.

Laser treatment[?] - Using a special strong beam of light of one color (laser) to heal a damaged area. A person with diabetes might be treated with a laser beam to heal blood vessels in the eye. See also: Photocoagulation.

Limited joint mobility[?] - A form of arthritis involving the hand; it causes the fingers to curve inward and the skin on the palm to tighten and thicken. This condition mainly affects people with IDDM.

Macrosomia[?] - Abnormally large; in diabetes, refers to abnormally large babies that may be born to women with diabetes.

Macrovascular disease - A disease of the large blood vessels that sometimes occurs when a person has had diabetes for a long time.

Macular edema[?] - A swelling (edema) in the macula, an area near the center of the retina of the eye that is responsible for fine or reading vision. Macular edema is a common complication associated with diabetic retinopathy. See also: Diabetic retinopathy; retina.

Meal plan[?] - A guide for controlling the amount of calories, carbohydrates, proteins, and fats a person eats. People with diabetes can use such plans as the Exchange Lists or the Point System to help them plan their meals so that they can keep their diabetes under control. See also: Exchange lists; point system.

Metformin - A drug treatment for type 2 diabetes; belongs to a class of drugs called biguanides.

Mg/dL[?] - Milligrams per deciliter. Term used to describe how much glucose (sugar) is in a specific amount of blood. In self-monitoring of blood glucose, test results are given as the amount of glucose in milligrams per deciliter of blood. A fasting reading of 70 to 110 mg/dL is considered in the normal (nondiabetic) range.

Microaneurysm[?] - A small swelling that forms on the side of tiny blood vessels. These small swellings may break and bleed into nearby tissue. People with diabetes sometimes get microaneurysms in the retina of the eye.

Microvascular disease - Disease of the smallest blood vessels that sometimes occurs when a person has had diabetes for a long time.

Mixed dose[?] - Combining two kinds of insulin in one injection. A mixed dose commonly combines regular insulin, which is fast acting, with a longer acting insulin such as NPH. A mixed dose insulin schedule may be prescribed to provide both short-term and long-term coverage.

Mononeuropathy[?] - A form of diabetic neuropathy affecting a single nerve. The eye is a common site for this form of nerve damage. See also: Neuropathy.

Necrobiosis lipoidica diabeticorum[?] - A skin condition usually on the lower part of the legs. The lesions can be small or extend over a large area. They are usually raised, yellow, and waxy in appearance and often have a purple border. Young women are most often affected. This condition occurs in people with diabetes, or it may be a sign of diabetes. It also occurs in people who do not have diabetes.

Neovascularization[?] - The term used when new, tiny blood vessels grow in a new place, for example, out from the retina. See also: Diabetic retinopathy.

Nephropathy[?] - Disease of the kidneys caused by damage to the small blood vessels or to the units in the kidneys that clean the blood. People who have had diabetes for a long time may have kidney damage.

Noninsulin-dependent diabetes mellitus[?] (NIDDM) - The most common form of diabetes mellitus; about 90 to 95 percent of people who have diabetes have NIDDM. Unlike the insulin-dependent type of diabetes, in which the pancreas makes no insulin, people with noninsulin-dependent diabetes produce some insulin, sometimes even large amounts. However, either their bodies do not produce enough insulin or their body cells are resistant to the action of insulin (see Insulin Resistance). People with NIDDM can often control their condition by losing weight through diet and exercise. If not, they may need to combine insulin or a pill with diet and exercise. Generally, NIDDM occurs in people who are over age 40. Most of the people who have this type of diabetes are overweight. Noninsulin-dependent diabetes mellitus used to be called "adult-onset diabetes," "maturity-onset diabetes," "ketosis-resistant diabetes," and "stable diabetes." It is also called type 2 diabetes mellitus.

Nonketotic coma[?] - A type of coma caused by a lack of insulin. A nonketotic crisis means: (1) very high levels of glucose (sugar) in the blood; (2) absence of ketoacidosis; (3) great loss of body fluid; and (4) a sleepy, confused, or comatose state. Nonketotic coma often results from some other problem such as a severe infection or kidney failure.

Optometrist[?] - A person professionally trained to test the eyes and to detect and treat eye problems and some diseases by prescribing and adapting corrective lenses and other optical aids and by suggesting eye exercise programs.

Peripheral neuropathy[?] - Nerve damage, usually affecting the feet and legs; causing pain, numbness, or a tingling feeling. Also called "somatic neuropathy" or "distal sensory polyneuropathy."

Peripheral vascular disease (PVD) - Disease in the large blood vessels of the arms, legs, and feet. People who have had diabetes for a long time may get this because major blood vessels in their arms, legs, and feet are blocked and these limbs do not receive enough blood.

Photocoagulation[?] - Using a special strong beam of light (laser) to seal off bleeding blood vessels such as in the eye. The laser can also burn away blood vessels that should not have grown in the eye. This is the main treatment for diabetic retinopathy.

Podiatry[?] - The care and treatment of human feet in health and disease.

Point system[?] - A way to plan meals that uses points to rate food. The foods are placed in four classes: calories, carbohydrates, proteins, and fats. Each food is given a point value within its class. A person with a planned diet for the day can choose foods in the same class that have the same point values for meals and snacks.

Polydipsia[?] - A great thirst that lasts for long periods of time; a sign of diabetes.

Polyphagia[?] - Great hunger; a sign of diabetes. People with this great hunger often lose weight.

Preeclampsia[?] - A condition that some women with diabetes have during the late stages of pregnancy. Two signs of this condition are high blood pressure and swelling because the body cells are holding extra water.

Previous abnormality of glucose tolerance[?] (PrevAGT) - A term for people who have had above-normal levels of blood glucose (sugar) when tested for diabetes in the past but who show as normal on a current test. PrevAGT used to be called either "latent diabetes" or "prediabetes."

Prognosis[?] - Telling a person now what is likely to happen in the future because of having a disease.

Proinsulin - The substance made first in the pancreas that is then made into insulin.

Purified insulins[?] - Insulins with much less of the impure proinsulin. It is thought that the use of purified insulins may help avoid or reduce some of the problems of people with diabetes such as allergic reactions.

Renal threshold[?] - When the blood is holding so much of a substance such as glucose (sugar) that the kidneys allow the excess to spill into the urine. This is also called "kidney threshold," "spilling point," and "leak point."

Risk factor[?] - Anything that raises the chance that a person will get a disease. With noninsulin-dependent diabetes, people have a greater risk of getting the disease if they weigh a lot more (20 percent or more) than they should.

Somatostatin[?] - A hormone made by the delta cells of the pancreas (in areas called the islets of Langerhans). Scientists think it may control how the body secretes two other hormones, insulin and glucagon.

Somogyi effect[?] - A swing to a high level of glucose (sugar) in the blood from an extremely low level, usually occurring after an untreated insulin reaction during the night. The swing is caused by the release of stress hormones to counter low glucose levels. People who experience high levels of blood glucose in the morning may need to test their blood glucose levels in the middle of the night. If blood glucose levels are falling or low, adjustments in evening snacks or insulin doses may be recommended. This condition is named after Dr. Michael Somogyi, the man who first wrote about it. Also called "rebound."

Spilling point[?] - When the blood is holding so much of a substance such as glucose (sugar) that the kidneys allow the excess to spill into the urine. See also: Renal threshold.

Split dose[?] - Division of a prescribed daily dose of insulin into two or more injections given over the course of a day. Also may be referred to as multiple injections. Many people who use insulin feel that split doses offer more consistent control over blood glucose (sugar) levels.

Stiff hand syndrome[?] - Thickening of the skin of the palm that results in loss of ability to hold hand straight. This condition occurs only in people with diabetes.

Systemic[?] - A word used to describe conditions that affect the entire body. Diabetes is a systemic disease because it involves many parts of the body such as the pancreas, eyes, kidneys, heart, and nerves.

Team management[?] - Describes a diabetes treatment approach in which medical care is provided by a physician, diabetes nurse educator, dietitian, and behavioral scientist working together with the patient.

Thrush - An infection of the mouth. In people with diabetes, this infection may be caused by high levels of glucose (sugar) in mouth fluids, which helps the growth of fungus that causes the infection. Patches of whitish-colored skin in the mouth are signs of this disease.

Tolazamide[?] - A pill taken to lower the level of glucose (sugar) in the blood. Only some people with noninsulin-dependent diabetes take these pills. See also: Oral hypoglycemic agents.

Tolbutamide[?] - A pill taken to lower the level of glucose (sugar) in the blood. Only some people with noninsulin-dependent diabetes take these pills. See also: Oral hypoglycemic agents.

Toxemia of pregnancy[?] - A condition in pregnant women in which poisons such as the body's own waste products build up and may cause harm to both the mother and baby. The first signs of toxemia are swelling near the eyes and ankles (edema), headache, high blood pressure, and weight gain that the mother might confuse with the normal weight gain of being pregnant. The mother may have both glucose (sugar) and acetone in her urine. The mother should tell the doctor about these signs at once.

Ulcer - A break in the skin; a deep sore. People with diabetes may get ulcers from minor scrapes on the feet or legs, from cuts that heal slowly, or from the rubbing of shoes that do not fit well. Ulcers can become infected.

Unit of insulin[?] - The basic measure of insulin. U-100 insulin means 100 units of insulin per milliliter (mL) or cubic centimeter (cc) of solution. Most insulin made today in the United States is U-100.

Urine testing[?] - Checking urine to see if it contains glucose (sugar) and ketones. Special strips of paper or tablets (called reagents) are put into a small amount of urine or urine plus water. Changes in the color of the strip show the amount of glucose or ketones in the urine. Urine testing is the only way to check for the presence of ketones, a sign of serious illness. However, urine testing is less desirable then blood testing for monitoring the level of glucose in the body. See also: Blood glucose monitoring; reagents.

Vaginitis[?] - An infection of the vagina usually caused by a fungus. A woman with this condition may have itching or burning and may notice a discharge. Women who have diabetes may develop vaginitis more often than women who do not have diabetes.

Vitrectomy[?] - Removing the gel from the center of the eyeball because it has blood and scar tissue in it that blocks sight. An eye surgeon replaces the clouded gel with a clear fluid. See also: Diabetic retinopathy.