John Clarkson (July 1, 1861 - February 4, 1909) was a 19th century Major League Baseball pitcher.

Playing for the Worcester Worcesters (1882), Chicago White Stockings (1884 - 1887), Boston Beaneaters (1888 - 1892) and Cleveland Spiders (1892 - 1894), Clarkson compiled a career 328-178 record. Clarkson pitched over 600 innings in a season twice and won a career-high 53 games in 1885. In MLB history, only Charles Radbourn has won more games in a single season (60 in 1884).

Clarkson was inducted into the Baseball Hall of Fame in 1963.

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