Stromoglandular and nodular hyperplasia is common in 8% of men in 40s, 50% of men in 50s, and 75% of men in 80s

Occurs only in men with intact testes (possibly due to accumulation of dihydroxytestosterone because of decr metabolism or incr intracellular binding)

Prostatic adenocarcinoma is also common (second most common malignancy in men)

Prostatic cancers often arise in the periphery of gland and can be detected with digital rectal exam

Spread can be local, into the bladder/seminal vesicles/prostatic urethra, or to adjacent LN; skeletal system is also common site of metastasis with characteristic osteoblastic changes that are easily distinguishable on radiographs

What is this? What problems can this cause? How can we tx it?

Stromoglandular or nodular hyperplasia of the prostate: both prostatic stromal and glandular elements are hyperplastic

Problems: often causes narrowing of prostatic uretrha with asx of hesitation and incomplete emptying of the bladder

Tx: can be medical or surgical, which involves shaving out chips of the prostate via the urethra (transurethral resection of the prostat eor TURP); chips are then examined microscopically to confirm BPH and look for malignancy