Revex Side Effects

Note: This page contains side effects data for the generic drug nalmefene. It is possible that some of the dosage forms included below may not apply to the brand name Revex.

For the Consumer

Applies to nalmefene: parenteral injection

Side effects include:

Nausea, vomiting, tachycardia, hypertension.

For Healthcare Professionals

Applies to nalmefene: injectable solution

Gastrointestinal

Gastrointestinal side effects have occurred commonly, with nausea and vomiting observed in 18% and 9%, respectively, of treated patients. Diarrhea and dry mouth have been reported in less than 1% of patients.[Ref]

Cardiovascular

Cardiovascular adverse effects including tachycardia, hypertension, hypotension, vasodilation, bradycardia, and arrhythmia have been reported in 5% or fewer of treated patients.[Ref]

Nervous system

Nervous system side effects including postoperative pain, dizziness, headache, fever, and chills have been reported in less than 5% of treated patients. Somnolence, depression, agitation, nervousness, tremor, confusion, and myoclonus have been reported in less than 1% of patients.[Ref]

Respiratory

A 21-year-old male with no significant past medical history had decreased respirations following an exploratory laparotomy for presumed appendicitis. The patient developed acute pulmonary edema after receiving 75 mcg nalmefene (the active ingredient contained in Revex) in 25 mcg increments over 10 minutes. Clinical resolution of symptoms was prompt after supplemental oxygen and furosemide. It took 36 hours for the chest X-ray to improve.[Ref]

Respiratory side effects have included pharyngitis (less than 1%). Pulmonary edema is an uncommon effect that has occurred with nalmefene administration.[Ref]

Dermatologic

Dermatologic side effects have infrequently included pruritus (less than 1%).[Ref]

Genitourinary

Genitourinary side effects have included rare reports of urinary retention (less than 1%).[Ref]

Other

Other side effects including fever (3%) and chills (1%) have been reported.

Consumer resources

Professional resources

Related treatment guides

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