Introduction: Liposarcomas are mesenchymal neoplasms with atypical adipocytes and lipoblasts in the background of mature adipose tissue. Retroperitoneal space offers an environment in which sarcomas can reach impressive sizes before they become symptomatic. Case Report: We are reporting a case of 45 years old previously healthy female with left flank and back slight pain and mild swelling on the left abdominal side. Woman visited her family physician, because of left flank pain. Abdominal ultrasound detected a large tumorous mass on the left retroperitoneal space. Enhanced contrast CT was performed after this and findings indicated tumor containing retroperitoneal fat also the collecting renal system was slightly expanded because of the tumor closely attached to the middle ureter. Midline laparotomy was performed and tumor en bloc with left kidney, left adrenal glands and surrounding adipose tissue was radically removed. Histological analysis revealed atypical – lipomatous tumor, G1 (well – differentiated). Conclusions: Liposarcoma is a malignant mesenchymal neoplasm composed of lipogenic tissue with varying degrees of atypia, which grow slowly and silently and may reach the enormous size. The main treatment of retroperitoneal sarcomas is radical surgery. Keywords: retroperitoneal space, well – differentiated liposarcoma, tumor removal.

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