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I have eye problems since I was 15. Now I have detached retina that forced me to undergo 3 surgical operations and now I have greatly increased pressure in my left eye. Luckily my new ophthalmologist prescribed me with Combiganand I consider it to be a great help. It has lowered my eye pressure from 45 to 11. I have no side effects, while with other drops I often noticed migraines and nausea.Combigan works great for me!