The location of this Byway is US Highway 75 that spans from Nashville, Nebraska (south of Fort Calhoun) to South Sioux city, Nebraska. It encompasses a 40 mile wide corridor that also involves communities to the south, west and north such as Omaha, Sioux City, and towns along nearby highways such as Highway 77.

Travelers will see beautiful vistas of rolling hills, trees, grasses and plants that are native to the Nebraska Loess Hills. Many historical sites and museums display exhibits of the local Nebraska cultures and folklore.