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Propolis is one of the world’s oldest medicines. It can fight infections, boost the immune system, and may help with type 2 diabetes. Used since prehistoric times, the ancient Egyptians even considered it holy. Read on to learn about the health benefits of propolis, along with potential side effects and dosage information.

What Is Propolis?

The natural form of propolis — also known as bee’s glue — is a hard, brittle resin, which becomes very sticky and waxy when heated up. The word propolis means “suburb” in Greek, as the bees use propolis to extend and defend their hives [R].

Propolis is produced by honeybees using plant parts and sap. Bees use propolis as a type of cement for building, repairing, and protecting their hives against bacteria and intruders. Observing bees, humans all over the world learned to use propolis for millennia as a health supplement, “cure-all”, and even for rituals such as mummification [R, R, R].

Recent research and interest in propolis revealed its additional health benefits for lowering blood pressure, strengthening the bones, helping to heal wounds, and protecting the liver [R, R].

This article will guide you through the modern uses and benefits of this ancient remedy.

Propolis Bioactive Compounds

The chemical makeup of propolis is closely connected to its geographical origin, flora, and the bee species. It can vary widely, even from hive to hive [R].

Organic propolis is typically dark brown or green in color, has a sweet smell and is made up of [R, R, R, R]:

Resins (50-70%)

Beeswax (30-50%)

Pollen (5-10%)

Essential oils (depends on the region, usually basil, thyme, and geranium) (5-10%)

Other compounds such as acids, sugars, and vitamins (B, C, and E) (5%-7%)

The main active ingredients in propolis are flavonoids such as chrysin, strong antioxidants that bees get from plant and flower parts. Bees make propolis by mixing their saliva with plant material, pollen, and beeswax [R].

Over 300 biologically active ingredients have been identified in propolis thus far, including fragrant chemicals, acids, carbohydrates, plant oils, and vitamins (B1, B2, C, and E). New types of propolis are being discovered as interest grows around the world [R].

Mechanism of Action

A large number of bioactive and antioxidant compounds in propolis explain its wide-ranging health benefits. Propolis acts in the body to [R]:

Kill bacteria and viruses by stopping their growth and spread [R, R, R]

Health Benefits of Propolis

1) Propolis Kills Bacteria and Viruses

Bees protect the hive from bacteria by covering debris with propolis to block the spread of harmful parasites [R].

Propolis can kill harmful bacteria, viruses, fungi, and parasites used either orally or on the skin. The two best-studied propolis varieties for this purpose are Brazilian propolis and European propolis. In one study of 30 children, a Brazilian propolis mouth rinse was effective at killing oral bacteria [R, R, R, R].

In a study on mice, propolis enhanced the activity antibiotic, antifungal, and antiviral drugs. Propolis attacks microbes by switching off their ability to make copies of themselves and grow [R, R, R].

2) Propolis Is An Antioxidant

Although most of the research was in cells or animals, a few recent human studies have also confirmed the antioxidant benefits of propolis.

In a clinical trial of 67 people, 15 drops of a propolis solution (Beepolis) twice daily acted as a potent antioxidant, increased the master antioxidant glutathione, as well as the “good” cholesterol HDL. It was given for 3 months and reduced the risk of heart disease [R].

In a clinical trial of 47 people, powdered propolis (with about 50 mg flavonoids/day) reduced oxidative stress in men by 23% after 30 days [R]

3) Propolis May Help with Type 2 Diabetes

Propolis may lower high blood sugar levels and improve blood sugar control in Type 2 diabetes, according to some human and animal studies [R].

4) Propolis Fights Yeast and Fungal Infections

Propolis fights yeast infections and other fungi by blocking their ability to form colonies in the body. In a study of 707 patients with fingernail fungal infections, propolis extract used applied to the nails cured infections in more than half of the participants after 6 months. It could penetrate the nail and destroy fungal biofilms [R].

In several cell studies, propolis stopped the formation of yeast clusters by dissolving this biofilm layer yeast cells use to cling to body surfaces, preventing an infection. I could also kill Candida and block its biofilms in cells [R, R, R, R].

5) Propolis May Lower Blood Pressure

In a study of 35 people, propolis slightly lowered blood pressure (both systolic and diastolic) when taken twice a day for 3 months [R].

6) Propolis May Help with Allergies

Overactivation of mast cells and histamine release is the leading cause of allergic reactions, including seasonal allergies, asthma, and eczema. In a mouse study, the flavonoid Quercetin found in propolis blocked histamine release and relieved allergic sinus symptoms [R, R, R].

Propolis supplementation seems to balance the Th1/Th2 response but is probably better for Th2-dominant people. Th1-dominant people should avoid propolis to prevent immune system overactivation.

In healthy mice, it reduced some inflammatory Th1 cytokines (IFN-gamma). In stressed mice, it enhanced the Th2 response. But in another mice study, it activated the Th1 response [R, R, R, R].

7) Propolis May Help Heal Wounds

Propolis supplementation may improve wound healing by boosting the growth of new skin cells, according to animal and cellular studies [R].

Using propolis for dental fillings may be one of the earliest forms of dentistry, dating thousands of years back. Ancient human skeletons with propolis and beeswax dental fillings have been discovered, the oldest one being from Slovenia and dating 6,500 years back [R, R].

Propolis Side Effects

Since there are many types of propolis, the side effects are hard to standardize. Generally, propolis is safe, except for people who are allergic to bees or bee products [R].

One study Italian reported 18 cases of negative reactions to propolis products over 5 years, of which 16 were allergic reactions, 7 were in people allergic to specifically to propolis, and 2 were gut issues [R].

Drug Interactions

Propolis blocked specific liver enzymes (CYP1A2) that metabolize many drugs in test tubes. It may increase the blood concentration and toxicity of drugs such as theophylline, acetaminophen, propranolol, and a number of antidepressants (including SSRIs) [R].

In cells, propolis boosts the effectiveness of antibiotics. It may help fight bacterial infections used alongside antibiotics, but clinical studies would need to attest to this [R, R].

Propolis Supplements and Formulations

Propolis is available in many forms, depending on the intended use:

Extracts, tinctures, and propolis spray

Dried powder, usually in capsules

Raw resinous propolis from the hive

Syrup for eating, mostly mixed with other extracts or honey

Propolis for skin: face and hand cream, gel, or ointment

Propolis shampoo

Propolis toothpaste

Propolis can be found in most health stores and pharmacies. The extract or tincture form of propolis has been researched the most, though the use of dental and skin formulations is also backed up by studies.

Propolis with Other Bee Products

Propolis, royal jelly, and honey all contain bioactive flavonoids. They are all antioxidants and anti-inflammatory. Used together, they can help fight inflammation, viral, bacterial, and fungal infections, speed up wound healing, and protect the heart [R].

The combination of propolis with honey and royal jelly is particularly good for fighting infections [R].

Can you eat Propolis?

Propolis is considered a health supplement, like other bee products. You can eat pure propolis, but it’s typically added to honey as an extract, which improves its taste. Propolis lozenges and chewing gum are also available.

Propolis Dosage

While there is no agreed upon dosage recommendation for propolis, it is considered to be non-toxic and safe except in people with allergies to bee products.

In clinical studies, the propolis dosage varied between 50-1000 mg/day with no side effects [R, R]

User Experiences

Consumers who purchased propolis from various health and wellness retailers reported positive experiences. They found propolis extracts, capsules, and tablets especially good for boosting the immune system and providing sore throat and sinus congestion relief.

Limitations and Caveats

Despite a long history of use in folk medicine around the world, clinical studies on propolis are limited. Human trials are rare and limited to specific types of propolis, which limits the knowledge about the benefits of other common varieties.

FDA Compliance

The information on this website has not been evaluated by the Food & Drug Administration or any other medical body. We do not aim to diagnose, treat, cure or prevent any illness or disease. Information is shared for educational purposes only. You must consult your doctor before acting on any content on this website, especially if you are pregnant, nursing, taking medication, or have a medical condition.

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JOE COHEN

CEO, SelfHacked

About Joe

Growing up, Joe was plagued with a myriad of health issues such as gut problems, autoimmune issues, chronic fatigue, brain fog, insomnia, and general inflammation. Both conventional and alternative doctors weren’t able to help him, so he decided to fix himself. With lots of health questions and few satisfying answers, Joe decided to read every research paper he could get his hands on and conduct thousands of experiments on his own body in order to fix his health issues. Joe started SelfHacked in late 2013 when he successfully fixed all of his issues, and now it gets millions of readers a month looking to educate themselves about how they can improve their health. Joe is now a thriving author, speaker, and serial entrepreneur, founding SelfDecode & LabTestAnalyzer.

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