Incidence of clinically important liver outcomes (as measured by hepatic encephalopathy (stage III or IV) or discontinuation of Raltegravir use where liver toxicity is listed as the reason for discontinuation. [ Time Frame: January 2000 -December 2014 ] [ Designated as safety issue: Yes ]

Incidence of Lipodystrophy events as measured by the detection of the first reported event for loss of fat from extremities, buttocks or face. [ Time Frame: January 2000 - December 2014 ] [ Designated as safety issue: Yes ]

All cause mortality (as measured by report of any death as collected for the follow-up visit for each patient) [ Time Frame: January 2000 - December 2014 ] [ Designated as safety issue: Yes ]

HIV-infected patients from the EuroSIDA study who are exposed to Raltegravir

Pre-Raltegravir

Historical comparison cohort of HIV-infected patients from the EuroSIDA study from the time period prior to the availability of Raltegravir for patient use

Non-Raltegravir

Concurrent comparison cohort of HIV-infected patients from patients in the EuroSIDA study that are contemporaneous with Raltegravir users but who are not exposed to Raltegravir

Detailed Description:

Time Perspective: Retrospective and Prospective

Eligibility

Ages Eligible for Study:

16 Years and older

Genders Eligible for Study:

Both

Accepts Healthy Volunteers:

No

Sampling Method:

Non-Probability Sample

Study Population

Adults 16 years old and older in the EuroSIDA database

Criteria

Inclusion Criteria:

Adults 16 years old and older with HIV-1

Exclusion Criteria:

Subjects will be excluded if they have no prospective follow up

Contacts and Locations

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study.
To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below.
For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01078233