The right-hander gave up two more, including a game-clinching grand slam to .000-hitting Taylor Teagarden in the sixth inning, as the Milwaukee Brewers fell to the New York Mets, 6-2, on Tuesday night at Citi Field.

Estrada (5-3) also issued four walks, all of which came around to score on those homers, in his six-inning, 97-pitch start against a Mets team that entered on a six-game losing streak.

He's now allowed a total of 20 homers in 79 innings, by far the most in the major leagues. Arizona's Wade Miley is second with 14.

Estrada also has given up at least one homer in 11 of his 12 starts. The only time he didn't was April 15 against St. Louis, a 6-1 loss.

"They're a concern if you're giving up a grand slam," said manager Ron Roenicke. "They're not that much of a concern if they're solo home runs. But all their runs were scored on homers. Six runs on two homers, and four hits? Those numbers don't add up real well."

Asked how much more rope he was willing to give Estrada before contemplating other options — prospect Jimmy Nelson being the most obvious candidate at Class AAA Nashville — Roenicke said he wasn't certain.

"I don't know. We'll have to talk about it," he said. "But it is concerning, because when this guy is right and he's aggressive, I know what he can do. This is a really good major-league pitcher, and he's not pitching like that."

The Brewers had their opportunities early against Mets starter Daisuke Matsuzaka, who was making just his third start after opening in the bullpen. He entered the night among the toughest pitchers to hit in the majors but also as the most walk-prone.

Indeed, he issued two free passes in the first only to see Aramis Ramirez fly out to left to end the inning. The Brewers collected their first two hits against Matsuzaka in the third, but again he got off the hook when Carlos Gomez grounded into an inning-ending fielder's choice.

Estrada was the first to make a major mistake in the bottom of the third.

With two outs, he walked leadoff man Ruben Tejada and two pitches later Daniel Murphy socked an 89-mph fastball into the seats in right field to give the Mets a 2-0 lead.

"Tried going in, left it up," said Estrada. "Murphy's a really good hitter, so that's what's going to happen when you make mistakes like that."

The Brewers got one of those runs back quickly, with Matsuzaka hitting Khris Davis with one out in the fourth and then Lyle Overbay doubling to right to drive Davis.

Matsuzaka settled back in from there, facing the minimum over the rest of his outing before leaving after the sixth. In a 100-pitch outing, he allowed three hits, one run (earned) and three walks to go along with five strikeouts.

Estrada's undoing came in the sixth when, after getting Murphy to fly out, he walked three of the next four hitters.

That brought up Teagarden, who joined the Mets just two days earlier from Class AAA Las Vegas. He fell behind, 1-2, before serving a homer to right that hit the top of the wall and over for a grand slam.

It was the first hit in the majors for Teagarden since last Aug. 30 with Baltimore, and it gave New York a 6-1 lead.

Hands on his head, Estrada could only watch helplessly as he second-guessed his pitch selection.

"It was more, 'What the hell am I doing? Why did I just throw that guy three straight fastballs?'" Estrada said .

"We went over the scouting report, I knew what I had to do and I didn't do it. I kept throwing fastballs for some reason. I think if I throw a good changeup there he might roll over or swing and miss. I've got to stick with my guns, my best pitch, and with bases loaded and two outs I didn't do it.

"I kept throwing fastballs."

Estrada got a flyout to end the inning, then made way for Mike Fiers in the seventh. But the damage had been done.

The homers were one thing, the walks another. Estrada came in having walked four in a game twice previously, including as recently as May 30.

"It's concerning because I know this guy is a guy that doesn't walk people," said Roenicke. "He walked the first guy, and Murphy comes up and hits the homer. Then he walks three guys and we get the homer. Marco's a guy that if he walks one guy a game, that's usually what he does. And we need to have that from him."

HITS AND MISSES

The Brewers out-hit the Mets, 6-5, on Tuesday but lost the game, 6-2. They fell to 28-4 when out-hitting their opponent.

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