Nanomedicine
Nanomedicine may be defined as the monitoring. repair. including molec lar machiner incl ding molecular machinery. the products and processes of molecular manufacturing. using engineered nanodevices and nanostructures. Nanotechnology Thorough. inexpensive control of the structure of matter based on molecule-by-molecule control of products and byproducts. construction and control of human biological systems at the molecular level.
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Nanomedicine cont…
Nanosurgery A generic t N i term including molecular repair and cell surgery. nanorobotics Bio-nanomaterial science Materials which are in direct contact with biological fluids or living tissue.000). i l di l l i d ll Nanodentistry The maintenance of comprehensive oral health by employing nanomaterials. with minimal adverse reaction or rejection by the body.)
. Nanomachine An artificial molecular machine of the sort made by molecular manufacturing. g (Nano-: A prefix meaning one billionth (1/1. nanomaterials biotechnology including tissue engineering and dental nanorobotics.000.000.

For what do you think medicine could use nanotechnology?
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What do you think medicine could use nanotechnology for?
Biomaterials Bone Teeth Cells Cartilage Immune system I t Viral and bacterial attack Drug delivery Diagnostics
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fibroblasts (responsible for new collagen fiber deposition during wound healing) migrate along the nano-sized grooves.g.Bioactive materials cont...
The goals is to alter the surface material by changing the atomic structure and chemistry e. and the size and g . to id ti d h li
. Ceramic is not very bioactive but when treated with Ion beam surface modification it become bioactive. shape of features can control the behavior of different cells. Biomaterial scientists can exploit such topographical controls to provide new ways t guide regeneration and healing. Cells align themselves to nano-scale features on a titanium surface. while macrophages (white blood cells responsible for digesting foreign matter) can become trapped within these features. For instance.

implant is desirable!! For other applications such as hemodynamic systems. tissue integration with the p pp y y . a nonadhesive inert nanodevice surface is desirable!!
.Fibroblast cell on a nanostructured surface
Note: that in many nanomedical applications.

Nanotechnology in medical research: where. when and why? h h d h ?
The European way:
European Technology Platform on NanoMedicine
Nanotechnology for Health
Vision Paper and Basis for a Strategic Research Agenda for NanoMedicine September 2005
Nanomedicine NanotechnologyforHealth
November 2006
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EUROPEAN COMISSION
European Technology Platform on NanoMedicine
Nanotechnology for Health
Vision Paper and Basis for a Strategic Research Agenda for NanoMedicine September 2005
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European Technology Platform on NanoMedicine
Nanotechnology for Health
Vision Paper and Basis for a Strategic Research Agenda for NanoMedicine September 2005
Nanomedical developments range from nanoparticles for molecular diagnostics imaging diagnostics.
. which may perform complex repair actions at the cellular level inside the body in the future. and therapy to integrated medical nanosystems.

of relieving pain.EUROPEAN SCIENCE FOUNDATION
The field of ‘Nanomedicine’ is the science and technology of di t h l f diagnosing. molecular knowledge of the human body. It was perceived as embracing five main sub-disciplines that in many ways are overlapping and underpinned by the following common technical issues. and of preserving and improving human health using molecular tools and health. t ti i treating and d preventing disease and traumatic injury. Regulatory and Toxicological Issues
Nanomedicine NanotechnologyforHealth
November 2006
. Analytical Tools • Nanoimaging • Nanomaterials and Nanodevices • N l Therapeutics and Drug Delivery Systems Novel Th ti dD D li S t • Clinical.

new tools for nanomedical testing and observation will include clinical in vivo cytography. real time whole-body real-time whole body microbiotic surveys. including the individual's medical history. immediate access to laboratory-quality data on the patient. auscultation bacteriology in the 19th century. baseline complaints Advancing technology has also brought a plethora of tests that contribute to accurate diagnosis including auscultation. genetic testing. and radiological scanning. microscopy and clinical diagnosis.
. and minimally invasive exploratory surgery in the 20th century. personal functional and structural baseline. century In the 21st century.At the Doctors Office
Examination and Diagnosis of a Patient The first step in any treatment process is the examination of the patient. clinical biochemistry. and current complaints.

nasal congestion. 24 hours we will have the first answers for the pathogen!) approx
. discomfort. (In approx.An Example
A patient presents in the clinic with mild fever. The cotton throat swab is mixed with a cocktail of DNA probes. A swab of his throat is taken. and cough. di f t d h b f hi th t i t k
What do we do now? The sample is analyzed by recombinant DNA techniques.

Key words: .The di Th diagnosis is completed in a f seconds. th infectious agent is i i l t d i few d the i f ti ti Promptly Exterminated and a resurvey with the probe several minutes afterwards reveals no evidence of the pathogen.Diagnostic .Treatment
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