Two of the 'Big Four' meeting in the quarter-finals seems almost unheard of. This blockbuster encounter is a final in its own right, and it was in 2012, when Murray claimed his maiden Grand Slam in an epic five-hour encounter.

A final that included the equal longest US Open men’s final in history, and the longest tie break in US Open finals history, which Murray won 12-10.

The two have an intense rivalry, with Djokovic leading 12-8 overall, and Murray leading 5-4 at Grand Slams. Four of the nine meetings the two have had at Grand Slams were for the title, which they are tied at 2 apiece.

Djokovic has had a flawless tournament so far, not dropping a set or even playing in a tiebreaker. On the other hand, Murray has had an easy but flawed passage, dropping two sets along the way.

Murray has already matched his quarter-final effort from last year, and will be looking to claim his second US Open title; however, Djokovic looks to also grab his second US Open title, having made the final for the last four years running, but only managing the one victory.

The Serb and the Brit are considered as two of the best clinical finishers, and they have put on a fine show at the Open so far. With Djokovic leading the tournament in break points won with 25, followed closely in second by Murray with 23.

The winner will face either Stan Wawrinka or Kei Nishikori in the semi-finals.