Fluoroblastin
msds (material safety sheet)

Fluoroblastin
Synthesis Reference

Fluoroblastin
Molecular Weight

Fluoroblastin
Melting Point

Fluoroblastin
H2O Solubility

< 0.1 g/100 mL at 19 °C

Fluoroblastin
State

Solid

Fluoroblastin
LogP

-0.77

Fluoroblastin
Dosage Forms

Topical preparations; Solution for injection

Fluoroblastin
Indication

For the topical treatment of multiple actinic or solar keratoses. In the 5% strength it is also useful in the treatment of superficial basal cell carcinomas when conventional methods are impractical, such as with multiple lesions or difficult treatment sites. Fluorouracil injection is indicated in the palliative management of some types of cancer, including colon, rectum, breast, stomach and pancrease.

Fluoroblastin
Pharmacology

Fluorouracil is an antineoplastic anti-metabolite. Anti-metabolites masquerade as purine or pyrimidine - which become the building blocks of DNA. They prevent these substances becoming incorporated in to DNA during the "S" phase (of the cell cycle), stopping normal development and division. Fluorouracil blocks an enzyme which converts the cytosine nucleotide into the deoxy derivative. In addition, DNA synthesis is further inhibited because Fluorouracil blocks the incorporation of the thymidine nucleotide into the DNA strand.