Project: Optimization of heterolgous proteins in lower enkaryots by manipulation of the clycosylation synthesis pathway.

project duration

01-OCT-94 – 31-DEC-99

abstract

We want to make glycosylstructures on heterologous proteins, produced in lower enkaryots, more resenblant to those from mammatian cells. To reach this aim of our project, we will try to modify the synthesis of N linked glycans in Trichoderma reesei. Simultanously we will search for glycam in different species of yeast and lifamentous fungi, that are acceptorsubstrate for vertebrate glycosyltransferases.