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When will the little Fockers grow up? The third—and, let's hope, final—chapter in the series about Greg and Pam Focker (Ben Stiller and Teri Polo) and their wacky parents is packed with stars in leading roles and cameos, but all that star power fails to bring on the humor. Little Fockers has one of the lowest laughs-to-attempted-jokes ratios in recent memory—a huge disappointment considering the talent assembled for the project.

The so-called plot revolves around a planned birthday party for Greg and Pam Fockers' young twins. The heart of the story is Greg's relationship with gorgeous pharmaceutical representative Andi (Jessica Alba), who entices Greg, a male nurse, to fulfill his potential and become a "medical superstar." How? By delivering a speech promoting a new erectile dysfunction drug, Sustengo.

If the premise sounds like one that might allow for insights into Greg and Pam's marriage, think again. The film isn't as interested in moral lessons as much as it is in gross-out gags. For instance, Greg and Andi bond by working together to administer an enema to a reluctant hospital patient. That's the level of the film's humor. There's also a subplot about the marital separation of Pam's sister from Dr. Bob, who was unfaithful to her, but the film never seriously addresses the impending divorce. It's used instead as fodder for further jokes about father-in-law Jack's (Robert De Niro) obsessive fixation on Greg, which has been the subject of countless gags since Meet the Parents introduced us to the trio of Jack, Greg and Pam.

Sex is the subject that ties together all the couples in this film. Jack sees what's happening with Greg and Andi, so he interrogates Greg about whether he's still attracted to Pam and whether they're still sexually active. Jack's wife, Dina (Blythe Danner), tries a little sexual role-playing to distract Jack from meddling into Greg's business. Then there are Greg's parents, Roz (Barbra Streisand) and Bernie (Dustin Hoffman), and their later-in-life marital crisis. Bernie has fled to Spain to study flamenco dancing, leaving Roz to the sex-advice TV show she hosts. And Pam's friend Kevin (Owen Wilson), after his latest failed relationship, returns to Pam's and Greg's town, professing Eastern philosophy and a love for Pam that pushes the boundaries of friendly affection.

Director Paul Weitz, who made the fine comedy In Good Company, can't do much with the sitcom-style antics of Little Fockers, so he peppers the film with sequences that are out of keeping with the rest of the storytelling. In one of these sequences, Jack stalks Greg on a subway train. In another, Jack chases Greg into a container filled with plastic balls at a kids' play center, leading Weitz to mimic a famous shot from Steven Spielberg's Jaws.

None of this makes the film better, but instead points out how hapless are Little Fockers' below-the-belt antics, pedestrian direction, and loads of underused stars. For instance, a subplot about Greg's and Pam's efforts to get their kids placed in an elite grade school goes nowhere but provides the film with yet another cameo from an actor (Laura Dern), who deserves better.

Readers are advised to review the lengthy list of content under the "Cautions" section below to see more details about this PG-13-rated misfire. Better yet, simply avoid Little Fockers at all costs.

CAUTIONS:

Language/Profanity: Multiple instances of the Lord's name taken in vain; discussion of intercourse and crude references made to male and female genitalia; excessive coarse language including a--, b-tch; d-mn; and s-it; boy asks that his finger be pulled, then passes gas.

Alcohol/Drugs: Andi and Greg drink wine with dinner, and Andi washes down a pill with the wine; Andi says she slept with a man after drinking too much; drinking at a social function

Sex/Nudity: Husband and wife kiss; plot revolves around Greg's promotion of an erectile dysfunction drug; illustration of male sex organ; Roz hosts a TV show on sex toys and promotes "musical condoms"; very frank discussion about or references to sex, sexual positions, masturbation, male and female sex organs; Kevin slaps the bottom of a bikini-clad woman; Jack and Greg are mistaken for a gay couple; Dina role-plays sexual games with Jack; Andi confesses her regret to Greg for sleeping with a doctor at a convention; Pam asks another couple to "keep it down" after a night of intimacy; a man gyrates sexually; Andi kisses Greg, takes off her top and skirt, and then jumps on him; Kevin kisses Roz.

Violence/Crime: Projectile vomiting; a knife cut, followed by spurting blood; Kevin puts a young boy to sleep by applying a certain pressure hold; Jack suggests planting a bomb near Bob, but then laughs off the idea; Greg's son walks in while Greg injects adrenaline into Jack to relieve symptoms from erectile dysfunction medicine; later, Greg's son draws a picture of what he saw; boy falls off climbing wall; Jack and Greg fight and throw punches at each other

Religion/Morals: Jack's daughter is going through a separation from her unfaithful husband; Bernie, claiming he's going through "man-o-pause," has left Roz behind to travel to Spain, study flamenco dancing, and find his "true north"; Kevin is into Eastern philosophies and medicine, and mentions "our man Buddha" as well as "J.C."