Chemical Gland p. 112. "These compounds must be naturally occurring and not synthetic." We only have stats for Synthetics...

Not that its particularly difficult to come up with stats for chemicals, but the cost is 100* the cost of the chemical so could result in a fairly large swing from table to table. Rough guidelines are probably needed, if not a specific list. Because, well, Adrenaline is 100% natural.

Yeah, that one was a trip on my own side. The 4th ed book just sat it out there and went "Done!" and let us hanging. I was eyeballing the deadline and trying to figure out what to do when the massive chamical chapter was finished and I went, "Okay, phew, we can roll with that." ... But about everything there is also synthetic, so doesn't work. D'oh!

So, yes, at some point, we'll need to make a nice long list of natural chemicals and their effects, from tree frog poison and cobra venom to insulin overdoses and low-grade adrenaline boosts.

So is the doubling of Essence cost in Skillwires also intended? What do people do that had them already, and are low on essence?Will they suddenly drop dead?

That, I have to find out. 0.1 Essence per Rating is where it was, and IMHO should stay, but, it might have been in the Playtesting feedback to switch it. That's a question for Upstairs. For now, go with 0.1 per Rating until we get the official stuff together. (As a heads-up, while I'll be working on a small package for the next week or two, the full one won't be out until after GenCon, I'm sure.)

Revels in Murder is easily abused and should be re-examined. A test to recover the edge instead of it being automatic and its still a powerful quality. *or* more serious RP restrictions. Social penalties, reputation damage, composure tests to take prisoners or leave an enemy alive after combat.

Something anyway. I like the test to confirm edge recovery, still powerful, but not automatic.

Slab is also in Stolen Souls p189, the entries in both books are almost exactly the same, minus one thing...well two I guess. One is that there is a note for an awaken version that affects the aura. and the other thing is that the Stolen Souls version does 16 stun damage. Which assuming, the target has 3 wil and 10 stun boxes, means a person who takes slab will take 3 physical overflow. Not sure if that stun damage is suppose to be there or if Chrome Flesh is errataing that out.

Tough and Targeted - person that comes after you is professional rating equal to your street Cred.Consummate Professional - Assassin's Primer Page 17- Street Cred is now equal to Karma / 20.

You can take a disadvantage to make another disadvantage less of a disadvantage. And, thematically, its as likely a combination as any. Change Tough and Targeted to person that comes after you is professional rating equal to your Karma / 10?

Dynomitan: The dynamin protein is closely tied to the speed of neuronal transmission due to the cellís ability to absorb neurotransmitters. Dynomitan is an enhanced version of this protein, expressed exclusively in the sensory regions of the brain. Characters with this modification receive a +1 dice pool modifier to Intuition-linked skills. Characters with this modification are also prone to distraction. When they notice something of interest, they must pass a Willpower + Logic (3) test to not drop the task at hand. This enhancement is incompatible with synch.