Three human prostate cancer cell lines and xenografts were utilized to examine the uptake of free 18F-FDHT and SHBG-bound 18F-FDHT. Both ligands were examined for stability and competitive binding to androgen receptor over time in vitro prior to in vivo studies. [J Nucl Med]
Abstract

A decrease in MYC and RAS expression was observed in all cell lines after treatment with miR-145, although statistical significance was achieved only in experiments with LNCaP and PC3 cell lines, with a decrease in 56% and 31% of RAS expression, respectively. [Apoptosis]
Abstract

A major clinical trial has become the first to show benefits of immunotherapy in prostate cancer – for some men with advanced, otherwise untreatable disease. Researchers showed that a subset of men who had run out of all existing options for treatment survived much longer than expected when taking immunotherapy. [Press release from The Institute of Cancer Research discussing research presented at the 2018 American Society of Clinical Oncology (ASCO) Annual Meeting, Chicago]
Press Release

Sensei Biotherapeutics, Inc. announced the publication of data from the company’s multi-center Phase I clinical trial to assess safety and immunogenicity of SNS-301 in patients with biochemically recurrent prostate cancer. [Press release from Sensei Biotherapeutics, Inc. discussing research presented at the 2018 American Society of Clinical Oncology (ASCO) Annual Meeting, Chicago]
Press Release

A prostate cancer drug has been provisionally rejected as a first-line treatment on the NHS in England. The draft recommendation from the National Institute for Health and Care Excellence means abiraterone won’t be made routinely available for men with newly diagnosed prostate cancer that has spread to other parts of the body. [Cancer Research UK]
Press Release

Northwestern’s newest center has officially launched with a bold mission and interdisciplinary mindset. The Center for Advanced Regenerative Engineering aims to create an ecosystem that enables researchers and clinicians to regenerate tissues and organs for adult and pediatric patients. [Northwestern University]
Press Release

Spain has a ministry of science again—and none other than the first Spanish astronaut is leading it. The new transition government led by socialist Pedro Sánchez announced that Pedro Duque, who visited space twice, will be at the helm of the newly created Ministry for Science, Innovation, and Universities. The announcement was cheered by the Spanish scientific community, which has long suffered from declining budgets and bureaucratic hurdles. [ScienceInsider]
Editorial

Scientists in Chile have welcomed a decision by Congress to create a science ministry. Many researchers hope that a dedicated ministry will give science more prominence and better-coordinated policies—provided the ministry’s budget matches the government’s ambitions to “bring Chile towards an information and knowledge society,” as Gonzalo Blumel, the country’s minister secretary-general of the presidency, put it in a statement issued after the 31 May vote. [ScienceInsider]
Editorial

The European Commission has outlined how it plans to spend the biggest research and innovation budget in its history. In a document that sets out plans for its next major science-funding program, the Commission also confirmed new rules that will, for the first time, allow any country in the world — including a post-Brexit United Kingdom — to take part. [Nature News]
Editorial