Lee, 6-foot-3, 205 pounds, has played in 167 career NHL games, all with the Senators. He has amassed five goals and 28 points after making his NHL debut during the 2007-08 season. In 2008-09 he ranked sixth among all rookie NHL defensemen in points with 13 and shots with 51. Lee also ranked ninth among rookie blue liners in average ice time with 18:53. He also played a career high of 53 games that season.

A native of Moorhead, Minnesota, Lee has played in 123 career AHL games with the Binghamton Senators, recording eight goals and 52 points. He played NCAA hockey for the North Dakota Fighting Sioux, playing in 82 games in two seasons. He was named to the WCHA all-rookie team in 2005-06. Lee also represented the United States at the World Junior Championships on two occasions.

Lee was drafted by the Senators in the first round, ninth overall, of the 2005 NHL Entry Draft.