Objective: Anti-rejection medicines, also known as immunosuppressive drugs, are prescribed to organ transplant recipients to prevent rejection of the new organ. Long-term use of these medicines put transplant recipients at higher risk of serious infections and certain types of cancer. The iWITH study seeks to do the following:

Find out if it is safe to slowly reduce and then completely stop the immunosuppression taken by children who have received liver transplants. This process is called “immunosuppression withdrawal” or ISW.

Find blood or liver biopsy tests that can help transplant doctors in the future predict if it is safe to decrease or stop immunosuppression drugs in children who have had a liver transplant.