The 2015 List of Prohibited Substances and Methods is now available. This
List will take effect on January 1, 2015.

Noteworthy changes compared to the 2014 List include:

PROHIBITED SUBSTANCES

S1: Anabolic Agents
• Changes were made to reflect current scientific
nomenclature.
• 5β-androstane-3α,17β-diol was added to the examples of
testosterone metabolites.
S2. Peptide Hormones, Growth Factors, Related Substances and Mimetics
• The title of this section has been changed: Mimetics have
been added to the title to reflect the fact that synthetic analogs are also
prohibited under this section.
• Please note that all the substances named as examples in
this revised section of the 2015 Prohibited List where already considered
prohibited under previous Prohibited Lists, as applicable.
• The ESA sub-section has been expanded by adding the
non-erythropoietic EPO-Receptor agonists.
• In addition, the HIF stabilizer sub-section has been placed
in a separate paragraph to highlight the growing importance of these drugs and
to specifically identify HIF activators such as xenon and argon. Note that
cyanocobalamin (vitamin B12) is not prohibited.
• Examples of Chorionic Gonadotrophin (CG) and Luteinizing
Hormone (LH) releasing factors have now been identified.
• A Corticotrophin releasing factor has now been added as an
example.
• GH releasing factors have been divided in a more precise
categorization and several examples of each have been added to illustrate their
different pharmacological properties.
• IGF-1 has been moved to the other growth factor section.
• Note that Platelet Derived Plasma preparations are not
prohibited.

S4. Hormone and Metabolic Modulators
• Trimetazidine was originally included in S6.b based upon
the similarity of its chemical structure to some of the listed Stimulants. It
has been moved to the newly created sub-section S4.5.c as it is
pharmacologically classified as a modulator of cardiac metabolism.
• AMPK activators were re-described to reflect current
nomenclature.
S5. Diuretics and Masking Agents
• The title and subsequent paragraphs has been modified by the
removal of the word “other” to reflect that diuretics are not only masking
agents but can also be abused for other purposes such as notably the induction
of rapid weight loss.
• The last paragraph has been reworded for the sake of
clarity. The principle and processes identified in the previous version of the
Prohibited List remain unchanged.

PROHIBITED METHODS

M2. Chemical and Physical Manipulation
• The term “surgical procedures” has been added to the
sentence describing the situations in which the administration of intravenous
infusions or injections of more than 50 mL per 6 hours are permitted when
medically required.

SUBSTANCES AND METHODS PROHIBITED IN-COMPETITION

S6. Stimulants:
• For the sake of clarification, topical/ophthalmic imidazole
derivatives have been mentioned as exceptions of non-prohibited stimulants.
• Phenmetrazine has been moved from section S6.a to S6.b to
reflect the fact that it is metabolized into fenbutrazate, which is already
listed under S6.b.
• The List now clearly identifies the whole family of
phenethylamine derivatives as being prohibited to address the growing number of
illegal, designer stimulants derived from phenethylamine.• Trimetazidine has been transferred to the newly created
section S4.5.c (see above).

S9: Glucocorticoids:
• Glucocorticosteroids are described as Glucocorticoids to
reflect current nomenclature and use.

In addition, please also note that with the occasion of the FINA Extraordinary
Congress to be held in Doha on 29 November 2014, the FINA Doping Control (DC)
Rules will be amended to reflect the new Word Anti-Doping Code 2015.