The Two and a Half Men star was pretty clearly speaking about his former co-star Charlie Sheen, who was fired from the CBS sitcom in April 2011 after a bizarre public meltdown, which included multiple tirades about series creator Chuck Lorre.

"People like that he's willing to just say whatever foolishness comes to the top of his head," Cryer said of Trump, denoting the "interesting overlap" between Sheen and the Republican presidential candidate. "It's fascinating to watch because I don't want people to pick the president based on entertainment value."

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Jon Cryer compares Donald Trump to Charlie Sheen: 'I don't want people to pick the president based on entertainment value'

Charlie Sheen, 1984. (Photo by Getty Images)

Charlie Sheen in a scene from the film 'Platoon', 1986. (Photo by Orion/Getty Images)

CLEVELAND - JULY 1: Actor Charlie Sheen in town to promote the movie 'Major League' prior to an Indians game at the Cleveland Municipal Stadium on July 1, 1988 in Cleveland, Ohio . (Photo by Janet Macoska/Michael Ochs Archives/Getty Images)

"I saw somebody spectacularly flame out and ruin everything that was good in their lives by doing that," he added. "I don't want somebody else to ruin everybody else's lives by coming to power that way."

Cryer notably attended a fundraiser for Sen. John McCain's presidential run in 2008, but says he's hesitant to align himself with either political party.

"What's funny is I've been to all kinds of fundraisers. I've been to Barack Obama fundraisers... but you go to one Republican one and boom, you're Republican forever," he explained. "I actually don't like to get into politics too much because who cares what the guy from Two and a Half Men thinks about politics."