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The Dolphins’ football team will head to Indianapolis this weekend for a clash with the Colts, but the business operation will stay behind to hold the team’s third annual Dolphins Cycling Challenge, a two-day bicycling event that has raised $1.6 million for cancer research at the Sylvester Comprehensive Cancer Center.

Approximately 1,500 riders will participate in the various races, which start at Miami-Dade at Sun Life Stadium, in Broward at Huizenga Plaza and in Palm Beach at CityPlace through the weekend. 100 percent of the proceeds of the race, held in honor of beloved former tight end and radio broadcaster Jim “Mad Dog” Mandich, are donated for cancer research.

Unfortunately, this also means some road closures for drivers. Here is the schedule of road closures in Dade and Broward this weekend:

SATURDAY

5:30-8:30 a.m.: Two northbound lanes on NW 12th Ave. from NW 14th St. to NW 15th St.

7-12:30 p.m.: Close two northbound lanes on SE 6th Ave. from SE 29th St. to US-1. Close one lane southbound on Us-1 from SE 28th Ave. to I-595. Close ramp from US-1 to westbound I-595.

8-2 p.m.: Close westbound I-595 from Eller Dr. to Davie Dr. Close northbound ramp from US-1 to I-595 west. Close one lane northbound US-1 from 1,400 feet south of airport. Close southbound I-95 ramp to I-595. Close northbound I-95 ramp to I-595 westbound. Close Turnpike ramp to I-595 westbound. Close northbound Turnpike ramp to I-595.

8-2 p.m.: Close northbound Davie Rd from eastbound SR-84 to westbound SR-84. Close one lane southbound on Davie Rd from SR-84 to SW 39th St.

8:30-12:30 p.m.: Close one lane southbound on Pine Island/Douglas Rd. from SW 30th St to NW 199th St. Close one lane eastbound on NW 199th St. from NW 37th Ave. to Sun Life Stadium.