While I'm not sure what happened, my parents computer has a virus, and now random ads, and sometimes music play in the background (no... IE, FF, Chrome, Safari, Opera, whatever are all closed). This happens on start-up, so I'm sure a hidden open program. If I pull up the Sound Mixer, I can see it under the application, but it is listed as "Name Not Available"

I've run Malwarebytes, Avira, Spybot S&D, and SuperAntiMalware, however I cannot seem to get rid of it.

I'll attach the log files from HijackThis, DDS, and GMER. While I'm all for re-imaging, my parents really want to avoid that.

I also saw from the logs that the computer also has java installed and it's out of date (More than likely the cause of the infection). If you don't need java get rid of it, and if you do need it for an app then disable it in the browser.

I'd recommend scanning the system externally with a kaspersky rescue disc. But to make the process go faster I would first run ccleaner and remove a lot of the temp files.

I would also recommend running patchmypc http://www.patchmypc.net and updating all of the 3rd party applications it finds to be out of date.

ive seen combofix screw up more computers than actually fix it, you need to run a rescue disc to actually clean those out

Never had it do anything bad to a system, you have to make sure you are running Combofix from normal mode not safe mode... plus, it's not really combofix's fault the system is jacked up in the first place.

I also saw from the logs that the computer also has java installed and it's out of date (More than likely the cause of the infection). If you don't need java get rid of it, and if you do need it for an app then disable it in the browser.

My initial instinct was that it was a Java vulnerability, I just didn't take the time to hunt it down. Like I said, it's my parents computer, so I never (normally) touch it.

Thank-you to everyone for the suggestions, I'll try them in a half hour when I get home, and I'll let you know how it goes.

Wow, hope the rescue disk finds it. The TDSSKiller only took about 5-10 minutes as I recall, and it definitely fixed this exact issue. Random audio ads playing and the same "Name Not Available" showing in the Volume Mixer. Good luck!