WJPR Citation

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World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar. Best Paper Award : Dr. Muhammad Baqir MR Fakhrildin
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Abstract

Background: In previous studies we have observed that methanol
extracts of fruit skins of various types of cultivated banana species
(Musa sapientum and Musa seminifera) can improve glucose tolerance
in glucose-loaded mice. The objective of this study was to evaluate the
glucose tolerance ability of methanol extract of fruit skins of a wild
banana species, Musa textilis Nee. Methods: Oral glucose tolerance
test (OGTT) was done to evaluate glucose tolerance. Results: In oral
glucose tolerance tests, methanol extract of fruit skins of Musa textilis
(MEMT) significantly and dose-dependently reduced blood glucose
levels in glucose-loaded mice by 21.4, 29.0, and 36.2%, respectively,
at doses of 100, 200 and 400 mg each per kg body weight in mice. By
comparison, a standard antihyperglycemic drug, glibenclamide, reduced blood glucose levels
by 39.3% at a dose of 10 mg per kg. MEMT, when administered at doses of 200 and 400 mg
per kg with 10 mg glibenclamide per kg demonstrated synergistic glucose lowering effect by
reducing blood glucose by 41.7 and 44.5%, respectively. Conclusion: MEMT can be used as
a blood glucose lowering agent in diabetic patients.