Note: Javascript is disabled or is not supported by your browser. For this reason, some items on this page will be unavailable. For more information about this message, please visit this page: About CDC.gov.

Figure 5

Figure 5. Dose–response relationship for A) incubation period and B) probability of infection of bovine PrP–expressing mice. Data were derived from an endpoint titration of 10% (wt/vol) frontal cortex homogenate from a patient with variant Creutzfeldt-Jakob disease. This homogenate was inoculated into tgBov mice (20 μL by intracerebral [ic] route; Table 1). This procedure was used to establish a model that estimates infectious titer in a homogenate on the basis of incubation period and the probability of infection in inoculated mice. Model plots are indicated by solid lines. +, observed value. LD50, 50% lethal dose.

The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.