A Summary of Research on the Effectiveness of Antidepressants and Psychotherapy Michael Conner, PsyD I n a 2002 review of research, Kirsch and Antonuccio (1) concluded that meaningful differences There is a significant gap between science and are lacking between antidepressants and placebos. In practice in the treatment of depression in America. 1998 Kirsch and Sapirstein (2) as