Oprah Winfrey: 'Time's Up' Is for 'Women of the World'

"She makes her points powerfully," Warren said. "I'm glad her voice is leading us in America."

Carol Fulp, president of The Partnership, created Massachusetts Women for Obama in 2008 and met Winfrey while working on the campaign. She called the speech moving, powerful and a lesson no one will forget.

But Fulp thinks it is time for a new, younger generation of leadership, and that Winfrey isn't interested in the job.

"While she may not be the candidate, she is going to help that candidate win, just like she helped that candidate win in 2008," Fulp said.

Winfrey has publicly said in the past she's not interested in being president. But since the speech, her longtime companion Stedman Graham was quoted as saying, "It's up to the people, she would absolutely do it."