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Son of a Bitch (SOB), and Son of a Gun, two variants, both euphemisms. There are varios theories regarding the origins of the phrase, however one can believe what they like. Can be put as an interjection expressing;
1. Surprise

5. (When you discover a friend of yours fucking a dog)
Dog; (trying to escape with all his strengh)...HEEELP! Get this fucker off me!"
Your girlfriend; "OH MY GOD!"
You; "...filthy son of a bitch!"

6. (Whilst taking a crap on your nieghbours front lawn, for pissing you off for some reason one evening)
Niehgbour; "What the hell do you think your doing?"
You; "What's it look like you son of a bitch?"

7. (When some friend of yours buys you a blowup sex doll for your birthday)
Tom; "here, hope you like it"
You; "aaaawww, you didn't have to, you son of a bitch"