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Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:query proteins and first shell of interactors

white nodes:second shell of interactors

Node Content

empty nodes:proteins of unknown 3D structure

filled nodes:some 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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Cooccurence

Coexpression

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[Homology]

Score

UMN179_00509

Hypothetical protein; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (510 aa)

Predicted Functional Partners:

UMN179_00508

Pyridine nucleotide transhydrogenase; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (457 aa)

0.999

nadK

Inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2’-hydroxyl of the adenosine moiety of NAD to yield NADP (306 aa)

a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1

node2

node1 accession

node2 accession

node1 annotation

node2 annotation

score

UMN179_00508

UMN179_00509

UMN179_00508

UMN179_00509

Pyridine nucleotide transhydrogenase; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane

Hypothetical protein; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane

0.999

UMN179_00508

UMN179_02185

UMN179_00508

UMN179_02185

Pyridine nucleotide transhydrogenase; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane

Dihydrolipoamide dehydrogenase

0.531

UMN179_00508

UMN179_02271

UMN179_00508

UMN179_02271

Pyridine nucleotide transhydrogenase; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane

Glutathione reductase

0.505

UMN179_00508

dapD

UMN179_00508

UMN179_00507

Pyridine nucleotide transhydrogenase; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane

2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase

0.507

UMN179_00508

nadK

UMN179_00508

UMN179_02301

Pyridine nucleotide transhydrogenase; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane

Inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2’-hydroxyl of the adenosine moiety of NAD to yield NADP

0.977

UMN179_00509

UMN179_00508

UMN179_00509

UMN179_00508

Hypothetical protein; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane

Pyridine nucleotide transhydrogenase; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane

0.999

UMN179_00509

UMN179_02185

UMN179_00509

UMN179_02185

Hypothetical protein; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane

Dihydrolipoamide dehydrogenase

0.508

UMN179_00509

UMN179_02271

UMN179_00509

UMN179_02271

Hypothetical protein; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane

Glutathione reductase

0.503

UMN179_00509

dapD

UMN179_00509

UMN179_00507

Hypothetical protein; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane

2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase

0.464

UMN179_00509

nadK

UMN179_00509

UMN179_02301

Hypothetical protein; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane

Inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2’-hydroxyl of the adenosine moiety of NAD to yield NADP

0.788

UMN179_02185

UMN179_00508

UMN179_02185

UMN179_00508

Dihydrolipoamide dehydrogenase

Pyridine nucleotide transhydrogenase; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane

0.531

UMN179_02185

UMN179_00509

UMN179_02185

UMN179_00509

Dihydrolipoamide dehydrogenase

Hypothetical protein; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane

0.508

UMN179_02185

UMN179_02271

UMN179_02185

UMN179_02271

Dihydrolipoamide dehydrogenase

Glutathione reductase

0.650

UMN179_02185

nadK

UMN179_02185

UMN179_02301

Dihydrolipoamide dehydrogenase

Inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2’-hydroxyl of the adenosine moiety of NAD to yield NADP

0.526

UMN179_02271

UMN179_00508

UMN179_02271

UMN179_00508

Glutathione reductase

Pyridine nucleotide transhydrogenase; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane

0.505

UMN179_02271

UMN179_00509

UMN179_02271

UMN179_00509

Glutathione reductase

Hypothetical protein; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane

0.503

UMN179_02271

UMN179_02185

UMN179_02271

UMN179_02185

Glutathione reductase

Dihydrolipoamide dehydrogenase

0.650

UMN179_02271

nadK

UMN179_02271

UMN179_02301

Glutathione reductase

Inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2’-hydroxyl of the adenosine moiety of NAD to yield NADP

0.512

dapD

UMN179_00508

UMN179_00507

UMN179_00508

2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase

Pyridine nucleotide transhydrogenase; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane

0.507

dapD

UMN179_00509

UMN179_00507

UMN179_00509

2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase

Hypothetical protein; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane

0.464

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Network Stats

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Functional enrichments in your networkNote: some enrichments may be expected here (why?)

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Statistical background

For the above enrichment analysis, the following statistical background is assumed: