It begins in Milledgeville, at an intersection with the SR-22 mainline and SR-69, in McNairy County. The highway travels due west for one block and curves to the northwest and enters Chester County. Just on the outer city limits of Milledgeville, SR-22A curves to a western routing and enters Enville. There, it intersects the northern terminus of SR-224 (Leapwood Road) and curves to the north-northwest. After a slight jog to the west, it resumes its north-northwesterly routing and leaves town. SR-22A travels through rural areas of the county and enters Jacks Creek, where it intersects SR-100. The alternate route then curves to the north-northeast and enters Henderson County. It eventually enters Lexington, where it intersects the northern terminus of SR-200 and curves to a due-east routing and meets its northern terminus, an intersection with the SR-22 mainline in the extreme southern part of the city.[2]

SR-22A is not part of the National Highway System, a system of roadways important to the nation's economy, defense, and mobility.[3]