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Malaria

Cause

Malaria is caused by the protozoan parasite Plasmodium. Human malaria is caused
by four different species of Plasmodium: P. falciparum, P. malariae, P. ovale and
P. vivax.

Humans occasionally become infected with Plasmodium species that normally
infect animals, such as P. knowlesi. As yet, there are no reports of human-mosquitohuman
transmission of such “zoonotic” forms of malaria.

Transmission

The malaria parasite is transmitted by female Anopheles mosquitoes, which bite
mainly between dusk and dawn.

Nature of the disease

Malaria is an acute febrile illness with an incubation period of 7 days or longer.
Thus, a febrile illness developing less than 1 week after the first possible exposure
is not malaria.

The most severe form is caused by P. falciparum; variable clinical features include
fever, chills, headache, muscular aching and weakness, vomiting, cough, diarrhoea
and abdominal pain. Other symptoms related to organ failure may supervene, such
as acute renal failure, pulmonary oedema, generalized convulsions, circulatory
collapse, followed by coma and death.The initial symptoms, which may be mild,
may not be easy to recognize as being due to malaria.

It is important that the possibility of falciparum malaria is considered in all cases
of unexplained fever starting at any time between 7 days after the first possible
exposure to malaria and 3 months (or, rarely, later) after the last possible exposure.
Any individual who experiences a fever in this interval should immediately seek
diagnosis and effective treatment, and inform medical personnel of the possible
exposure to malaria infection. Falciparum malaria may be fatal if treatment is
delayed beyond 24 h after the onset of clinical symptoms.

Young children, pregnant women, people who are immunosuppressed and elderly
travellers are particularly at risk of severe disease. Malaria, particularly P. falciparum,
in non-immune pregnant travellers increases the risk of maternal death,
miscarriage, stillbirth and neonatal death.

The forms of human malaria caused by other Plasmodium species cause significant
morbidity but are rarely life-threatening. Cases of severe P. vivax malaria have
recently been reported among populations living in (sub)tropical countries or areas
at risk. P. vivax and P. ovale can remain dormant in the liver. Relapses caused by
these persistent liver forms (“hypnozoites”) may appear months, and rarely several
years, after exposure. Relapses are not prevented by current chemoprophylactic
regimens, with the exception of primaquine. Latent blood infection with P. malariae
may be present for many years, but it is very rarely life-threatening.

In recent years, sporadic cases of travellers’ malaria due to P. knowlesi have been
reported. Humans can be infected with this “monkey malaria” parasite while staying
in rainforests and/or their fringe areas in south-east Asia, within the range of
the natural monkey hosts and mosquito vector of this infection. These areas include
parts of Cambodia, China, Indonesia, Laos, Malaysia, Myanmar, the Philippines,
Singapore, Thailand and Viet Nam. The parasite has a life-cycle of 24 h and can
give rise to daily fever spikes occurring 9–12 days after infection. Symptoms may
be atypical. Severe P. knowlesi malaria with organ failure may occur, and sporadic
fatal outcomes have been described. P. knowlesi has no persistent liver forms and
relapses do not occur. Travellers to forested areas of south-east Asia where human
P. knowlesi infections have been reported should protect themselves against
mosquito bites between dusk and dawn to prevent infection and take the usual
chemoprophylaxis where indicated (see Country list).

Geographical distribution

The current distribution of malaria in the world is shown on the map in this chapter;
affected countries and territories are listed both at the end of this chapter and in
the Country list. The risk for travellers of contracting malaria is highly variable
from country to country and even between areas in a country, and this must be
considered in any discussion of appropriate preventive measures.

In many countries or area at risk, the main urban areas – but not necessarily the
outskirts of towns – are free of malaria transmission. However, malaria can occur
in the main urban areas of Africa and, to a lesser extent, India. There is usually
less risk at altitudes above 1500 m, although in favourable climatic conditions
the disease can occur at altitudes up to almost 3000 m. The risk of infection may
also vary according to the season, being highest at the end of the rainy season or
soon after.

There is no risk of malaria in many tourist destinations in south-east Asia, the
Caribbean and Latin America.

Risk for travellers

During the transmission season in countries or areas at risk, all non-immune travellers
exposed to mosquito bites, especially between dusk and dawn, are at risk of
malaria. This includes previously semi-immune travellers who have lost or partially
lost their immunity during stays of 6 months or more in countries or areas of no
risk. Children who have migrated to countries and areas of no risk are particularly
at risk when they travel to malarious areas to visit friends and relatives.

Most cases of falciparum malaria in travellers occur because of poor adherence to,
or complete failure to use medicines, or use of inappropriate prophylactic malaria
drug regimens, combined with failure to take adequate precautions against mosquito
bites. Studies on travellers’ behaviour have shown that adherence to treatment
can be improved if travellers are informed of the risk of infection and believe in
the benefit of prevention strategies. Late-onset vivax and ovale malaria may occur
despite effective prophylaxis, as they cannot be prevented with currently recommended
prophylactic regimens which act only against blood-stage parasites.

Malaria risk is not evenly distributed where the disease is prevalent. Travellers to
countries where the degree of malaria transmission varies in different areas should
seek advice on the risk in the particular zones that they will be visiting. If specific
information is not available before travelling, it is recommended that precautions
appropriate for the highest reported risk for the area or country should be taken;
these precautions can be adjusted when more information becomes available on
arrival. This applies particularly to individuals backpacking to remote places and
visiting areas where diagnostic facilities and medical care are not readily available.
Travellers staying overnight in rural areas may be at highest risk.

Precautions

Travellers and their advisers should note the four principles – the ABCD – of
malaria protection:

Be Aware of the risk, the incubation period, the possibility of delayed onset,
and the main symptoms.

Avoid being Bitten by mosquitoes, especially between dusk and dawn.

Take antimalarial drugs (Chemoprophylaxis) when appropriate, to prevent
infection from developing into clinical disease.

Immediately seek Diagnosis and treatment if a fever develops 1 week or more
after entering an area where there is a malaria risk and up to 3 months (or, rarely,
later) after departure from a risk area.