In 2151, while exploring an uncharted M-class planet, the crew of Enterprise became affected by tropolisine that was blown down from the mountains during a windstorm. It was discovered by Dr. Phlox that inaprovaline, combined with being removed from the pollen-saturated environment would allow the effects of tropolisine to dissipate. (ENT: "Strange New World")

By the early 23rd century, a permanent cure for the hallucinogenic effects of tropolisine had been found, allowing Humans to settle the planet.

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