In a breakthrough study using laboratory mice, the matrix of
nutraceuticals was found to produce more striking changes in gene
expression, and influence more genes, in comparison to mice placed on
research-grade resveratrol or a calorie restricted (CR) diet. The
nutriceutical matrix favorably affected more biological pathways (by 3-4
fold) compared to CR. The study utilized microrrays which provide data on
the expression level of over 20,000 genes. The study was conducted in mouse
heart tissue.

The results of the mouse study were unexpected and surprising, pointing
to a synergistic action when multiple natural molecules are employed. The
nutriceutical matrix provided red wine molecules resveratrol and quercetin
and the rice bran factor known as IP6. All three are mineral-chelating
(key-lay-ting) molecules.

The short-term study not only showed the nutriceutical matrix exerted
broader effects upon gene expression than CR or resveratrol, but
molecularly mimicked gene patterns typically seen with long-term calorie
restriction.

Of the 2829 genes significantly affected by any of the three dietary
interventions employed (CR, resveratrol, or nutriceutical matrix), the
limited calorie diet affected about 187 genes (7%), resveratrol about 224
genes (8%), while the nutriceutical matrix influenced 1711 genes (61%),
over a 9-fold difference.

Recent studies that have captured the public's attention have focused
on molecules that can slow aging and have been narrowly focused on the
sirtuin family of genes and their activation by resveratrol, known as a red
wine molecule. Recently researchers have reported that entire gene networks
rather than single genes are involved in metabolic disorders, such as
elevated blood sugar and cancer. Researchers report that gene array testing
can detect genes affected by an unhealthy diet before there is change shown
in the blood sample. [Nature March 16, 2008]

The nutriceutical matrix of natural molecules (Longevinex(R)) exhibited
a much broader impact upon gene expression and more strikingly affected key
genes, like Pdk4 and Pgc1 alpha, involved in mitochondrial energy
metabolism.

Only the nutriceutical matrix, and not resveratrol or a long-term
calorie restricted diet, upregulated the Foxo1 gene which enters the cell
nucleus and promotes the expression of key longevity genes.

These effects were accomplished with a relatively low human equivalent
dose of resveratrol. At about 1/15th the dose employed in a prior widely
acclaimed mouse study (Nature Magazine Nov. 1, 2006) the nutriceutical
matrix was able to exert more demonstrable genomic effects.

Prior animal studies employed the human equivalent of 1565, 360 and 343
milligrams of resveratrol to produce longevity effects. The nutriceutical
matrix exerted 9-fold greater effect over the mouse genome at the
equivalent daily human dose of resveratrol of 100 milligrams per day.
According to this study, if data from mice is applicable to humans, some
widely promoted mega-dose resveratrol pills, providing 500 to 1000
milligrams of resveratrol, would not exert as broad an effect over the
human genome as the lower-dose resveratrol when provided in a matrix of
other mineral-chelating natural molecules.

The discovery was made utilizing laser scanning technology to measure
levels of messenger-RNA from thousands of genes in tissues obtained from
test animals. Researchers used a commercially available GeneChip(R)
(Affymetrix), which is about the size of a credit card.

Mice and humans share about 99% of their 30,000 genes. Most gene
expression changes caused by aging are partially or completely prevented by
CR. This discovery is suggestive of a day when humans could molecularly
avert the effects of over-eating as well as slow or even reverse the aging
process without having to deprive themselves of food.

A life-long CR diet is anticipated to influence more than the 200 genes
shown in this short-term study, but the nutriceutical matrix exerted
influence much sooner, raising the possibility that adherence long-term CR
may not be required to obtain the same benefits.

The study was sponsored by Resveratrol Partners LLC, maker of
Longevinex(R), a patent-applied-for nutriceutical (http://www.longevinex.com).

Resveratrol Partners LLC is a privately held Nevada limited liability
company that markets its unique nutriceutical dietary supplement solely
under the LONGEVINEX(R) trade name. Google has chosen to affix the stock
symbol of another unrelated company to their GOOGLE NEWS listing for this
press release, but Resveratrol Partners LLC, dba LONGEVINEX(R) has no
affiliation with that or any other company.

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