A Phase 1 Dose-Escalation Study of the Safety, Pharmacokinetics, and Pharmacodynamics of XL647 and XL147 Administered in Combination Daily to Subjects With Solid Tumors

Trial Information

A Phase 1 Dose-Escalation Study of the Safety, Pharmacokinetics, and Pharmacodynamics of XL647 and XL147 Administered in Combination Daily to Subjects With Solid Tumors

Inclusion Criteria:

- The subject has a histologically confirmed solid tumor that is metastatic or unresectable and is no longer responding to therapies known to prolong survival or to other standard therapies, or has disease for which no standard therapy exists.

- The subject is capable of understanding and complying with the protocol and has signed the informed consent document.

- Sexually active subjects (male and female) must agree to use accepted methods of contraception during the course of the study and for 3 months after the last dose of protocol drug(s).

- Female subjects of childbearing potential must have a negative pregnancy test at screening.

- Subjects in the MTD Expansion Cohort:

- Must have measurable disease per Response Evaluation Criteria in Solid Tumors (RECIST).

- Must have a histologically confirmed diagnosis of NSCLC (Stage IIIB or IV) OR a histologically confirmed diagnosis of metastatic breast cancer.

Exclusion Criteria:

- The subject has received cytotoxic chemotherapy (including investigational cytotoxic chemotherapy) within 3 weeks (or nitrosoureas or mitomycin C within 6 weeks) before the first dose of XL647.

- The subject has received prior treatment with a small molecule kinase inhibitor (including an investigational kinase inhibitor) within 14 days before the first dose of XL647.

- The subject has received any other type of investigational agent within 30 days before the first dose of study treatment.

- The subject has not recovered from toxicity due to prior therapy.

- The subject has had major surgery within 30 days before the first dose of study drug. Subjects must have recovered or stabilized from prior surgery.

- The subject is known to have diabetes.

- The subject is currently receiving anticoagulation with warfarin (low-dose warfarin ≤ 1mg/day, heparin, and low-molecular weight heparins are permitted).

- The subject has prothrombin time (PT)/International Normalized Ratio (INR) and /or partial thromboplastin time (PTT) test results at screening that are above 1.3 times the laboratory upper limit of normal.

- The subject has any of the following cardiac criteria:

- Corrected QT interval (QTc) of > 0.46 seconds

- Has a finding of left bundle branch block

- Has important bradycardia defined as a heart rate of < 50 bpm due to sinus node dysfunction

- Has an obligate pacemaker

- History of sustained ventricular arrhythmias (subjects with a history of atrial arrhythmias should be discussed with the sponsor before entry into the study)

- Family history of congenital long QT syndrome or unexplained sudden death

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