@article {Gozalo:2007:1532-0820:396,
author = "Gozalo, Alfonso S and Lucas, Carmen M and Qin, Jing and Hall, Ted B and Magill, Alan J",
title = "Anemia and Antibodies to the 19-kDa Fragment of MSP1 During Plasmodium falciparum Infection in Aotus Monkeys",
journal = "Comparative Medicine",
volume = "57",
number = "4",
year = "2007",
publication date ="2007-08-01T00:00:00",
abstract = "To determine whether antibodies to the 19-kDa fragment of merozoite surface protein 1 (MSP119) help to control blood-stage Plasmodium falciparum infection, we performed a rechallenge experiment of previously infected Aotus monkeys. Monkeys previously exposed to the FVO strain of P. falciparum that did or did not develop high antibody titers to MSP119 and malaria-na{\"ı}ve monkeys were challenged with erythrocytes infected with the same strain. Prepatent periods were prolonged in previously infected monkeys compared with malaria-na{\"ı}ve monkeys. Previously infected monkeys with preexisting anti-MSP119 antibodies showed low peak parasitemias that cleared spontaneously. Previously infected monkeys that had no or low levels of pre-existing anti-MSP119 antibodies also showed low peak parasitemias, but because of low hematocrits, all of these animals required treatment with mefloquine. All previously malaria-na{\"ı}ve animals were treated because of high parasitemias. The results of this study suggest that antibody to the 19-kDa carboxy-terminal fragment of MSP1 plays a role in preventing the development of anemia, an important complication often associated with malaria.",
pages = "396-401",
itemtype = "ARTICLE",
parent_itemid = "infobike://aalas/cm",
issn = "1532-0820",
publishercode ="aalas",
url = "http://www.ingentaconnect.com/content/aalas/cm/2007/00000057/00000004/art00009"
}