Recent advances in methodology for clinical trials in small populations: the InSPiRe project.

Where there are a limited number of patients, such as in a rare disease, clinical trials in these small populations present several challenges, including statistical issues. This leads to an EU FP7 call for proposals in 2013. One of the three projects funded is the Innovative Methodology for Small Populations Research (InSPiRe) project. The InSPiRe project leads to development of novel statistical methodology for clinical trials in small populations in four areas. In addition it is produced a free software in order to facilitate implementation of the novel methods. More information about the project you can find here.