Drug Interactions With Naprosyn

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More Detail About Interactions With Naprosyn

The following sections provide more detail on the interactions with Naprosyn listed above.

ACE Inhibitors

Combining Naprosyn with an ACE inhibitor can increase the risk of kidney problems, especially in people who already have kidney problems, and can decrease the effectiveness of the ACE inhibitor for lowering blood pressure.

ARBs

Combining Naprosyn with an ARB can increase the risk of kidney problems, especially in people who already have kidney problems, and can decrease the effectiveness of the ARB for lowering blood pressure.

Beta Blockers

Combining Naprosyn with a beta blocker may interfere with the beta blocker's ability to lower blood pressure. Check with your healthcare provider before taking these medications together.

Bile Acid Sequestrants

Bile acid sequestrants can bind to Naprosyn in the digestive tract and delay its absorption into the body. To avoid this drug interaction, Naprosyn should be taken at least one hour before or four to six hours after the bile acid sequestrant has been taken.

Corticosteroids

Using corticosteroids with Naprosyn can increase the risk of bleeding. Your healthcare provider may choose to monitor you more closely or adjust your dose of these drugs.

Cyclosporine

Naprosyn may increase the level of cyclosporine in the blood, increasing the risk of serious side effects of cyclosporine. In addition, this combination may increase the risk of kidney damage. Check with your healthcare provider before taking these medications together.

Digoxin

Naprosyn may increase the level of digoxin in your bloodstream, increasing the risk of dangerous side effects of digoxin. If you are taking digoxin, check with your healthcare provider before starting or stopping Naprosyn.

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