Target Name

Target Species

Species Detected

Expected cross-reactivity with mouse based on sequence similarity.
N.B. Antibody reactivity and working conditions may vary between species., Mouse

Application Notes

This product detects a band of approximately 51kDa in rat brain membrane fractions.

Recommended Applications

Western Blotting

Specificity

This product recognizes an epitope within the N-terminal region (NT) of the alpha 1 subunit of rat gamma-aminobutyric acid (A) (GABAA) receptor.

GABAA receptors are GABA gated chloride channels, which are important mediators of neuronal inhibition in the mammalian central nervous system. Activation of the GABAA site results in increased intracellular chloride concentration and hyperpolarization of the cell.

GABAA receptors are pentameric structures assembled from a family of distinct subunits. At least fourteen distinct subunits have been identified, which show distinct patterns of temporal and spatial expression.

GABAA receptors may be modulated by several drug types including benzodiazepines and barbiturates, and by phosphorylation by protein kinase C (PKC) and protein kinase A (PKA).

Storage/Stability

Store at +4 °C or at -20 °C if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 12 months after receipt.