Duplamin
msds (material safety sheet)

Duplamin
Synthesis Reference

Duplamin
Molecular Weight

Duplamin
Melting Point

Duplamin
H2O Solubility

Duplamin
State

Solid

Duplamin
LogP

4.946

Duplamin
Dosage Forms

Tablet; Suppository; Opthalmic drops; Syrup

Duplamin
Indication

For the treatment of allergic disorders, itching, nausea and vomiting.

Duplamin
Pharmacology

Promethazine, a phenothiazine, is an H1-antagonist with anticholinergic, sedative, and antiemetic effects and some local anesthetic properties. Promethazine is used as an antiemetic or to prevent motion sickness.

Duplamin
Absorption

On average, 88% of a promethazine dose is absorbed after oral administration; however, the absolute bioavailability is only 25% because of first-pass clearance.

Duplamin
side effects and Toxicity

Symptoms of overdose include mild depression of the central nervous system and cardiovascular system to profound hypotension, respiratory depression, unconsciousness, and sudden death. Other reported reactions include hyperreflexia, hypertonia, ataxia, athetosis, and extensor-plantar reflexes (Babinski reflex). LD50=55mg/kg (I.V. in mice)