Category: tech savvy

We are in the era with 100,000 protein structures available. Now we need to analyse what the crystallographic community already have rather than predicting probes in the vacuum.

When you know the ligand is bound inside the identifiable PDB crystal structure, it is surely affect that protein and we showed you the associated Ki from peer-review literature. So that is how we build the bridge from structures to precision medicine.

The residues that you want to fish out from the multiple alignment conservation may be there but may not be a must. The atoms that must be there are atoms that stay there and pair up with the ligand most of the time. The residues that causes the change in binding affinities is what you want to fish for selectivity.

What the drug community need is perhaps a linker such as MANORAA to go all the way from ligands to proteins, pathways, SNPs and target human organs plus a bit of help from the collaborative effort from various disciplines.

It is the very first attempt that ligand structures can complement the drug discovery pipeline with mostly experimental data source support to the expression levels.

It works on your phone, tablet, mac and PC so I can browse my drug on the go.

Its ligand superposition function allows you to make programmable code for fragments superposition on the URL so your drug fragment remains anonymous.

A Bluetooth speaker, my merry,
When I was cranky then feel right
With classical music calm my mind,
With shiny speaker worth the pence.
I also have a breathing mousey,
with seven LED on my bench,
Light on my keyboard worth every cents,
I enjoy everything, jingle bells.
-Wi Tanramluk

In this Hi-Tech world, everything gets smaller,
but my love is as grand as ever.
Wish I have a bigger hard disk to install programs
And increase the RAM,
So it looks fab with your photo on the desktop.

In digital world we argue and compromise,
I make E-card and E-mail to apologise.
The CPU knows I love you so;
Don’t take it carelessly and throw
Our love down to the recycle bin.

On SMS, I text you to define
the most heart-melting lines of mine;
I let WinAmp run with the song ‘Miss you’.
My intention is to
impress you how passionate about you I am.

Downloaded songs for you, they are my favorites.
Darling, please reply that you’ve got it.
Don’t rush shutting down and go
as I will let my mind flow
to you along the cable line.

Please, can you save our love, keep it forever,
so that my heart isn’t just an error.

waiting for my codes to compile.
Life seems a bit sour,
SuSE doesn’t let me type Thai.
Can you see my sorrow?
Oh…o my Monday has gone.
If the problem last till tomorrow,
I will have an ice-cream cone.
-Wi Tanramluk

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Ajarn Wi

I'm a lecturer living in Bangkok. I love to work at the interface between Art & Science.