Miradon

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Prescribing Information

Miradon (anisindione) is an anticoagulant used to prevent and treat venous thrombosis and its extension, the treatment of atrial fibrillation with embolization, the treatment of pulmonary embolism, and as an adjunct in the treatment of coronary occlusion. The brand name of this medication is discontinued, but generic versions may be available. Common side effects include stomach upset or headache as your body adjusts to the medication.

SIDE EFFECTS

Multisystem adverse reactions have been reported, and some may be serious enough to warrant hospital admission. In general, they may be divided into 2 categories: those which involve abnormal bleeding and other effects which do not. Hemorrhage and/or necrosis are among the hazards of treatment with any anticoagulant and are the main serious complications of therapy. For additional discussion of possible hemorrhagic complications following oral anticoagulant therapy see WARNINGS. Although most of the adverse reactions for oral anticoagulant drugs have been reported for warfarin, dicumarol, and phenindione, all the drugs within this class have similar pharmacologic and clinical properties, and require the same degree of caution in monitoring adverse reactions regardless of the drug administered.

Some indanediones (phenindione)have been associated with undesirable reactions which have not been reported with the coumarins and are not counterbalanced by advantages, thus perhaps favoring the use of the coumarin-type anticoagulants. Changing from one chemical type of oral anticoagulant to the other may eliminate an adverse reaction, such as rash or diarrhea. Dermatitis is the only untoward reaction consistently associated with anisindione therapy.

Side effects which have additionally been reported for coumarin derivatives include:vomit-ing, abdominal cramps, anorexia, priapism, ery-thema and necrosis of the skin and other tissues, manifesting as purple toes and cutaneousgangrene. There is no reason to expect that some or all of these adverse reactions might not occur in patients receiving anisindione.