The Jaguars will choke off the run with Saquon Barkley, and then tee off on Manning. The Jacksonville offense will be better than a year ago and Leonard Fournette will have a big opener here to take the pressure off Blake Bortles, who will be efficient and make some key throws down the field.

Jacksonville will win this one easily. Lay the points on the road.

Desperately wish you had a 30-minutes-or-so, daily NFL podcast in your podcast app every morning by 6 a.m.? Put some Pick Six Podcast in your life and join Will Brinson as he breaks down the latest news and notes from around the league, as well as the win totals on a team-by-team schedule. It's a daily dose of football to get you right for that commute or gym trip. Subscribe:via iTunes | via Stitcher | via TuneIn | via Google Play

This number looks funny. The Saints have a good team coming back with a lot of rising, young stars. But Tampa Bay's roster has made huge improvements this offseason, especially on defense.

I expect that Tampa Bay defense to be much better against the pass than a year ago, which will make it tough going here for the Saints, especially without Mark Ingram to help the running game. Ingram is suspended for the first four games.

Jameis Winston has to cut down on his turnovers, which he will do with help of the improved running game with Ronald Jones. The Bucs might actually win this game, so getting a touchdown is a gift.

It was just a few years ago when these two met in the Super Bowl with the Seahawks routing Denver.

Now they are both in transition.

That doesn't mean they are headed for disaster seasons, but Seattle is starting fresh on defense, which will put more pressure on the offense. That's not a good thing against a Denver defense that still has premium talent, players like elite pass rusher Von Miller. I think the Broncos defense will play well, while Case Keenum will have a good first start for the Broncos.

The Rams are the chic, trendy pick to be a potential Super Bowl pick in the NFC. And I agree they will be a good team.

But opening on the road on a Monday night against an Oakland team with coach Jon Gruden back on the sidelines will be tough duty. I expect Gruden to get Derek Carr back playing like he did in 2016, when he was an MVP candidate.

The Rams have loaded up on defense, but they still have issues when it comes to the edge rush, which is a key in their system. I think Gruden's offense will have success because of that here.

The Dolphins will be better than most expect. They have a lot of turnover on their roster, but it's a good thing. The players will buy into what coach Adam Gase wants, rather than some malcontents complaining about little things. The culture change will be a good thing.

With Ryan Tannehill back at quarterback, the offense will be better. And they have some good, young talent on defense.

The Titans have a good team, and I like coach Mike Vrabel. But this is a new staff coaching on the road in an opener. That won't be easy.

I think this will be close, but I like the Dolphins plus the points at home.

Pick Six Newsletter

Get the day's big stories + fun stuff you love like mock drafts, picks and power rankings.

I agree that CBS Sports can send me the "Pick Six Newsletter" newsletter.

Thanks for signing up!

Keep an eye on your inbox for the latest sports news.

Sorry!

There was an error processing your subscription.

Pete Prisco has covered the NFL for three decades, including working as a beat reporter in Jacksonville for the Jaguars. When he's not watching game tape, you can find Pete on Twitter or dreaming of an...
Full Bio