Frontal cortex BDNF levels correlate with working memory in an animal model of Down syndrome

Heather A Bimonte-NelsonDepartment of Physiology and Neuroscience and the Center for Studies on Aging, Medical University of South Carolina, 173 Ashley Avenue, Charleston, SC 29425, USABehav Brain Res 139:47-57. 2003

ERK-mediated NGF signaling in the rat septo-hippocampal pathway diminishes with age

Heather A Bimonte-NelsonDepartment of Physiology and Neuroscience, Medical University of South Carolina, Charleston 29425, USABehav Neurosci 117:1395-406. 2003

..The hypothesis that long-term ovarian hormone loss is detrimental to spatial memory in aged rats was not supported. The authors hypothesize that removal of elevated progesterone levels is related to the ovx-induced cognitive enhancement...

..These findings further support Ts65Dn mice as a model for specific AD-like symptoms, and demonstrate that estrogen treatment of this type does not improve the cognitive ability of male Ts65Dn mice...

Frontal cortex BDNF levels correlate with working memory in an animal model of Down syndrome

Heather A Bimonte-NelsonDepartment of Physiology and Neuroscience and the Center for Studies on Aging, Medical University of South Carolina, 173 Ashley Avenue, Charleston, SC 29425, USABehav Brain Res 139:47-57. 2003

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ERK-mediated NGF signaling in the rat septo-hippocampal pathway diminishes with age

Cognitive dysfunction in HIV encephalitic SCID mice correlates with levels of Interferon-alpha in the brain

ANDREW R SASMedical University of South Carolina, Department of Microbiology and Immunology, USAAIDS 21:2151-9. 2007

..Interferon alpha (IFNalpha) is an antiviral cytokine produced in response to viral infection. IFNalpha also acts as a neuromodulatory molecule in the central nervous system (CNS). Elevated IFNalpha in the CNS causes cognitive deficits...

..The current findings suggest that profound changes in neurotrophin protein levels can occur within only a few months time, and that these changes influence whether age-related neurotrophin alterations are realized...