The aim of the present work is to find out the effect of ultrasound on adsorption/desorption of carboxymethyl cellulose (CMC) onto mesoporous activated carbon (MAC) derived from the mustard cake. Adsorption/desorption experiments will are conducted in the presence and absence of ultrasound at 20 kHz. Results indicate that the adsorption of the CMC onto MAC surfaces in the presence of ultrasound is lower than the amount of adsorption observed in the absence of ultrasound. The ultrasonic power input during the adsorption/desorption indicating that particles absorb ultrasonic energy effectively. This ultrasonic energy is dissipated into heat resulting in increase in desorption. The adsorption/desorption step has a great impact on the binding mechanism in the present case. The observed results employing ultrasound will have new insight in surface chemistry.