It is perhaps best known as the current home of the world's largest insurance market, Lloyd's of London, since its newest building was opened on the street in 1986. Opposite Lloyd's, the Willis Building is the global headquarters of insurance broker Willis. A 35-storey building has been proposed at 52-54 Lime Street, and upon approval and completion by 2017 will become the European headquarters of global insurer W. R. Berkley.

The northern portion of the street is pedestrianised. Vehicular through-access to Leadenhall Street is prevented by a firegate, forcing drivers to bear right onto Fenchurch Avenue, from which a left turn onto Billiter Street returns vehicles to Leadenhall Street.