Hematology

Hematology:

1. What is the earliest hematopoietic cell?
2. Name the form that iron is incorporated into?
3. What enhances the release of oxygen from hemoglobin?
4. What is the pathway that increases NADPH and glutathione?
5. Abnormal monocyte/macrophages changes seen in this type disease

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Hematology.

1. What is the earliest hematopoietic cell?

Bone marrow contains cells called hematopoietic stem cells, which generate all the cell types of the blood and the immune system. Hematopoietic stem cells are also found in small numbers in peripheral blood and in larger numbers in umbilical cord blood. In bone marrow, hematopoietic stem cells are anchored to osteoblasts of the trabecular bone and to blood vessels. They generate progeny that can become lymphocytes, granulocytes, red blood cells, and certain other cell types, depending on the balance of growth factors in their immediate environment.

2. Name the form that iron is incorporated into?
The average adult contains 4-5&#8201;g of iron, of which 60-70% is present in the blood as haem in the circulating haemoglobin, and the remainder present in myoglobin in muscles, a variety of enzymes, and tissue stores. Iron is stored in the liver as ferritin, in other tissues as haemosiderin, and as the blood transport protein transferrin.