The earliest attestations historical towns down in 1437 when the district is certified Teleșeuca village. Other localities that Arionești, Corbu, Crișcăuți, Horodiște and Tîrnova are documented during 1463–1470. In the following centuries district towns or developed both socially and culturally. In 1812 the Treaty of Bucharest, Bessarabia is occupied by the Russian Empire as a district for more than 100 years (1812–1918) Russian administration fall. In spring 1888 construction start Bălși–Ocnița railway which ended in 1893. Railway history is closely linked to the city of Dondușeni during the years 1902–1905 the building near the railway station, built in 1892, held the construction of pumping station and water tower, two warehouses for grain and a ramp load, two kilometers of road and three houses. 1918 register a new page in the history of Bessarabia. On 27 March, Sfatul Țării of Bessarabia voted for the Union of Bessarabia with Romania. As a member of the Country's Council vote for Grand Union and Simeon Galiţchi (1887–1940), sergeant major of the infantry regiment of Odessa, a native of Donduşeni and ardent patriot of the Romanian people, who died in summer 1940 as a result of Stalin's Great Purge. Following the pact between Hitler and Stalin from 26 June 1940 the fate of Bessarabia was determined by military force. On 22 June 1941 include the start of 1418 days and nights of fierce and bloody fights between the Germans and Soviets. In this period perplexed more than half the male population was mobilized to Donduşeni station and sent searing flames of war. Eternal remembrance of the 17 men of Donduşeni that victory came at the cost of life. During the 1946–1947 district endure hunger caused by the communists. In 2004 the district population was 47,400.

Located in the north-eastern part of Moldova with neighboring districts Ocnița District in the north, west Edineţ District, south Rîşcani District, Drochia and Soroca in the southeast. Also has border with Ukraine in the north-east.
Relief of district located on the Plateau of Moldavia is mainly flat with small disturbances in rivers. Erosion has a small intensity. Chernozems occupy 80% of the district. Maximum altitude in the district is located near the village Pocrovca, reaching heights of 247 m.

Donduşeni district has a temperate continental climate with an annual average temperature of 9–10 °C in July mean temperature is 20 °C, while in January, 4 °C. Yearly precipitation is 450–600 mm. Wind speed is an average speed of 2–5 m/s.

The largest park in Moldova is located in the middle of the village of Ţaul, about 200 km north of Chişinău and 5 km from Donduşeni. Territory whole gully occupies a depression with steep slopes that decrease to the south, and land with mild relief that and all buildings are located above the park. Compositional core and the focus of contemplation is the whole mansion, open park boundaries not only vision but also the village due to the dominant position in the village.To the left of the palace, the exotic trees shade around the lawn and flower gardens with picturesque glade was built box-resorts, hosting house guests, kitchen and group destination auxiliary buildings. The assembly of Taul village bore little change over time and remains a monument of classical characteristic of the early 20th-century residence. The compositions of landscapes and found the most appropriate ideas materialize planning landscape gardens, developed in Europe at the end of the 19th century, and many species of garden is a precious treasure arboretum.

Located in the Nistru river basin district bordering the river only a small portion near the village Arioneşti. The main river crossing the district is Răut (286 km), which takes its origins from the confluence of two streams within 2 km east of the village Rediul Mare, at an altitude of 180 m, with tributaries Cubolta (103 km) and Cainari. Răut is the largest tributary of the Nistru. Most lakes are artificial origin.

There is an ongoing controversy over whether Romanians and Moldovans are the same ethnic group, namely whether Moldovans' self-identification constitutes an ethnic group distinct and apart from Romanians or a subset. At the census, citizens could declare only one nationality. Consequently, one could not declare oneself both Moldovan and Romanian.

As of 2009, 18,311 businesses were registered in the district. Most of these were private (individual) farms. 532 km2. of the district's 645 km2 area is agricultural land, including 333.23 km2 of arable land, and 38.88 km2 of orchards. Main crops are cereals cultivation in the district: wheat and barley, maize, sugar beet, sunflower, rapeseed and soy.

At of 2009, there were 21 kindergartens in the district. There were 7 lyceums (grades 1–12), 3 secondary schools (grades 1–11), 15 gymnasiums (grades 1–9),
1 primary school (grades 1–4), one or more professional schools (grades 12–13), and one or more boarding schools for orphans.

Located in the so-called North Red, region where PCRM which usually has good results obtained from 2001 until now over 50% of the vote. But the last three elections the Communists are in constant decline. District is one of the founding members of Euroregion Dniester.

There are 23 public libraries, 22 culture halls, and 1 museum in Donduşeni district. There are also 87 art groups. In recent years several houses were repaired by culture, or open more libraries, especially in villages. Village libraries are equipped with books in large numbers.

There is a hospital with 135 beds, and an outpatient health center with 10 branches, and 10 physician offices. All villages of the district were reading a medical point of 5–6 physicians in the environment.