This Concentration is designed for students who want to understand biological systems holistically and quantitatively, and pursue research with an emphasis on systems and integrative principles in biology. The curriculum in this Concentration imparts an understanding of systems biology (often called the new physiology) using dynamical systems, control, computer simulation and other computational methods – integrated with the biology. Typical problem areas include single-scale or multiscale modeling for enhancing understanding of regulatory biomechanisms at molecular, cellular, organ and/or whole-organism levels. A major challenge is to integrate proteomic, transcriptomic and metabolomic information into a more complete picture of living organisms. The methodologies also extend readily to studies of societal or ecosystem problems, as well systems-level problems in medicine and pharmacology.