The want to harm yourself is an unsafe sign of low mood (depression). It may last until your low mood is fully treated. If you are planning on harming yourself, call the ER (emergency department) right away.

When used to stop smoking this drug may cause or make diseases of the mind worse. Taking one's own life, ideas of killing yourself or murder, low mood (depression), forceful actions, hallucinations, and psychoses have happened with use. If you think you have any of these problems, call your doctor right away.

Chance of seizures may be higher. Talk with the doctor.

Sometimes drugs are not safe when you take them with certain other drugs. Taking them together can cause bad side effects. This is one of those drugs. Be sure to talk to your doctor about all the drugs you take.

Please read the medication guide.

Avoid

If you have an allergy to bupropion or any other part of this drug.

Tell your doctor if you are allergic to any drugs. Make sure to tell about the allergy and what signs you had. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.

If you have any of these health problems: Eating problem or seizures.

If you have taken isocarboxazid, phenelzine, or tranylcypromine in the last 14 days. Monoamine oxidase inhibitors (eg, isocarboxazid, phenelzine, and tranylcypromine) must be stopped 14 days before this drug is started. Taking both at the same time could cause risky high blood pressure.

Precautions

You may have some heart tests before starting this drug. Talk with your doctor.

If you are allergic to tartrazine, talk with your doctor. Some products have tartrazine.

Do not use AplenzinT, ForfivoT XL, Wellbutrin®, or Zyban® at the same time. They are the same drug.

If you have been taking this drug for many weeks, talk with your doctor before stopping. You may want to slowly stop this drug.

If you abuse beer, wine, mixed drinks, or cocaine, talk with your doctor.

If you have heart disease, talk with your doctor.

Have your blood pressure checked often if you have heart disease or are taking a product to replace nicotine.

If you have kidney disease, talk with your doctor.

If you have liver disease, talk with your doctor.

Check all drugs you are taking with your doctor. This drug may not mix well with some other drugs.

Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.

Feeling lightheaded, sleepy, having blurred eyesight, or a change in thinking clearly. Avoid driving and doing other tasks or actions that call for you to be alert or have clear eyesight until you see how this drug affects you.

Long-acting tablet shell in the stool.

Hot flashes. Wearing layers of clothes or summer clothes and staying in cool places may help.

The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.