Violent criminals who can't be killed are shooting up Los Angeles, and the investigation leads LAPD detectives Roger Mortis (Treat Williams) and Doug Bigelow (Joe Piscopo) to a mysterious pharmaceutical firm. But when Mortis is suddenly murdered, his coroner girlfriend and loose cannon partner discover the company's "resurrection machine" that turns Roger into the walking dead. Now the department's most unstoppable cops must battle zombie hit men, a butcher shop gone berserk and the deceased industrialist (the legendary Vincent Price in one of his final film roles) who may hold the key to it all. But can Mortis solve his own homicide case before he completely decomposes?