Anne Siegel, Research director, computer science, CNRS

Research

Research field

Short Bio. Anne Siegel is a research director at CNRS, located at IRISA, the computer science laboratory of Rennes. She is the leader of the Dyliss group (IRISA and Inria Rennes) which develops formal methods for the integration of heterogenous data in biology. She started her carreer in mathematics and theoretical computer science by studying symbolic dynamical systems to investigate self-similar structures in number theory and tilings. Then she explored the field of systems biology, that is, the modeling and study of dynamical systems in molecular biology.

Her main research now focuses on constraint-based methods to interpret large-scale observations of a molecular system in a dynamical system framework, with applications to marine biology and extremophile microbiology.

Longer (old) Bio

Short Bio

I am a former student in mathematics at Ecole Normale Supérieure de Lyon (1994-98). I succeeded at the "Agregation de mathematics" in 1997. I received my Ph-D thesis in 2000 at the math lab (IML)[35] of Université de la Méditerannée in Marseille. My thesis was focused on combinatorial and number-theoretic descriptions of substitutive dynamical systems. After a 4 monthes service as an assistant professor position (McF) at the laboratory of mathematics in Rennes[36] (IRMAR), the CNRS offered me a position of research scientist (CR2) at the computer science laboratory of Rennes[37] (IRISA). I joined the bioinformatics group. Since then, I have been conducting researches in both symbolic dynamics[38] (focusing on applications in numeration and discrete geometry) and systems biology[39]. I received my habilitation thesis in mathematics and computer science[40] in 2008 at the university of Rennes 1. I was promoted as a research director at CNRS in 2010. Since 2012, I have been the leader of the Dyliss team. The domain of the team is bioinformatics and systems biology. The team develops qualitative formal systems for a better understanding of key actors of non-modeled species when they are challenged by their environment, such as algae which have to adapt to tide or bacteria which survive in highly sulfured mines. I have been an elected member (2009-2012) then a nominated member (2015-2019) of the Inria Evaluation committee, as well as a nominated member (2012-2014) of the CNRS comittee for evaluation in mathematics. I also regularly join or preside some project or laboratory evaluation panels (ERANet in plant sciences, Cancer Plan in Systems Biology, HCERES, ANR). In 2014, I was a founder then a co-animator of a national working group about computational/symbolic systems biology (bioss) at the cross-over of the two national networks (GDR) in Informatics-Mathematics (GDR IM) and Bioinformatics (GDM BIM).