The residents try to impress Jackson’s mother, Catherine Avery, when she comes to Seattle Grace to perform a groundbreaking surgery; Alex and Arizona encounter a familiar face in the ER; Bailey makes a choice about her love life.

A woman without a uterus asks Jake and Addison to help her have a baby; Amelia treats a woman with Parkinson’s disease who is habitually unfaithful; Violet struggles with her life as a stay-at-home mom.

Caroline tries to make sure the Mystic Falls High School’s senior prank night goes as planned; Damon thinks Jeremy can help defeat Klaus; Stefan is used for increasingly dangerous and violent purposes.