Compare Buspar vs. Cymbalta

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Buspar (buspirone) relieves anxiety with less drowsiness and abuse potential than other anti-anxiety medicines, but it takes time to work and effects might wear off over time.

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3.4/ 5 average rating with 67 reviewsforBuspar

Improves mood and relieves certain types of pain.

Cymbalta (duloxetine) is good for treating depression, anxiety, and some forms of chronic pain, but it is more likely than other antidepressants to cause problems if you drink alcohol or have high blood pressure.

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3.6/ 5 average rating with 496 reviewsforCymbalta

Upsides

Doesn't cause as much physical dependence or withdrawal symptoms as other medications used for anxiety.

Available as a generic, which is cheaper.

Tablets can be split for easy dose changes.

Doesn't cause as much drowsiness as other medications for anxiety.

Cymbalta (duloxetine) may help relieve nerve pain from diabetes and other forms of chronic pain.

Cymbalta (duloxetine) has several uses, which may be good for people with multiple conditions.

Available as a generic, which is cheaper.

Downsides

Not for quick relief of anxiety symptoms since Buspar (buspirone) can take as long as 4 weeks to fully work.

Not as effective for short-term anxiety conditions or panic disorders.

Some people find that Buspar (buspirone) loses effectiveness over long periods of time.

Must take Buspar (buspirone) twice daily for full effect.

Cymbalta (duloxetine) may not be a good option if you're a heavy drinker, or have liver or kidney problems.

Cymbalta (duloxetine) can increase high blood pressure.

Like most antidepressants, Cymbalta (duloxetine) can cause higher risk of suicidal thoughts and behavior for people aged 24 and younger.