Comments on: The secret of longevity for the world’s longest-living rodent: better protein creationhttp://www.kurzweilai.net/the-secret-of-longevity-for-the-worlds-longest-living-rodent-better-protein-creation
Accelerating IntelligenceSun, 02 Aug 2015 19:57:36 +0000hourly1http://wordpress.org/?v=3.4.1By: ohMMhttp://www.kurzweilai.net/the-secret-of-longevity-for-the-worlds-longest-living-rodent-better-protein-creation/comment-page-1#comment-224356
ohMMMon, 07 Oct 2013 00:30:45 +0000http://www.kurzweilai.net/?p=208537#comment-224356In other news: Research proves NOT celebrating birthdays are good for your health. Studies have shown that people that have less birthdays stay younger.
Science.. always disproving itself ;-) hard to tell what is truth anymore..In other news: Research proves NOT celebrating birthdays are good for your health. Studies have shown that people that have less birthdays stay younger.

]]>By: GatorALLinhttp://www.kurzweilai.net/the-secret-of-longevity-for-the-worlds-longest-living-rodent-better-protein-creation/comment-page-1#comment-224127
GatorALLinSun, 06 Oct 2013 15:49:15 +0000http://www.kurzweilai.net/?p=208537#comment-224127In other news: Research proves celebrating birthdays are good for your health. Studies have shown that people that have more birthdays live longer.In other news: Research proves celebrating birthdays are good for your health. Studies have shown that people that have more birthdays live longer.
]]>By: ohMMhttp://www.kurzweilai.net/the-secret-of-longevity-for-the-worlds-longest-living-rodent-better-protein-creation/comment-page-1#comment-223722
ohMMSat, 05 Oct 2013 17:45:38 +0000http://www.kurzweilai.net/?p=208537#comment-223722Bri will always be wrong. :-)
You would need a Downgrade to get to his level!
As long as you don't act so righteous like she does, then you are already doing science, you just need to fill in the details on the big picture.
You watched 'My'left'toe'con'dre'ah'.. you say? nice movie, Bri should watch it too.Bri will always be wrong. :-)

You would need a Downgrade to get to his level!

As long as you don’t act so righteous like she does, then you are already doing science, you just need to fill in the details on the big picture.

You watched ‘My’left’toe’con’dre’ah’.. you say? nice movie, Bri should watch it too.

]]>By: someday69http://www.kurzweilai.net/the-secret-of-longevity-for-the-worlds-longest-living-rodent-better-protein-creation/comment-page-1#comment-223695
someday69Sat, 05 Oct 2013 16:22:26 +0000http://www.kurzweilai.net/?p=208537#comment-223695Some times eye feel like the mole rat. Living Underground,So long,with'out much'inteligence', then Up to the sun'n'the light'of reason'. You People with career's,in science,,It's all so over'whelm'ing,,So eye don't want to even really try,Too make any in'roads,,don't expect to really Understand/(Grook) the Science/Yet'I did see the movie'My'toe'con'dre'ah-..then yu say',,Ribosome/ ///My bad. I meant ribosome. They are the factories. Mitochondria are Tge powerhouses.// Then even that isn't Right enough? // * tHe powerhouses. :-)
See what eye mean? It's like some race'I've already lost. So people like me..who will look at them'selfs AZz the mole rat...in the way that eye dew...
We can only wait for the ....Wet'ware Up'grades.......someday....Some times eye feel like the mole rat. Living Underground,So long,with’out much’inteligence’, then Up to the sun’n'the light’of reason’. You People with career’s,in science,,It’s all so over’whelm’ing,,So eye don’t want to even really try,Too make any in’roads,,don’t expect to really Understand/(Grook) the Science/Yet’I did see the movie’My’toe’con’dre’ah-..then yu say’,,Ribosome/ ///My bad. I meant ribosome. They are the factories. Mitochondria are Tge powerhouses.// Then even that isn’t Right enough? // * tHe powerhouses. :-)
See what eye mean? It’s like some race’I've already lost. So people like me..who will look at them’selfs AZz the mole rat…in the way that eye dew…
We can only wait for the ….Wet’ware Up’grades…….someday….
]]>By: Joseph C.http://www.kurzweilai.net/the-secret-of-longevity-for-the-worlds-longest-living-rodent-better-protein-creation/comment-page-1#comment-223030
Joseph C.Fri, 04 Oct 2013 02:12:13 +0000http://www.kurzweilai.net/?p=208537#comment-223030How does their previous finding on HMW-HA interact with this new discovery?
http://www.kurzweilai.net/biologists-identify-chemical-behind-cancer-resistance-in-naked-mole-ratsHow does their previous finding on HMW-HA interact with this new discovery?

]]>By: ohMMhttp://www.kurzweilai.net/the-secret-of-longevity-for-the-worlds-longest-living-rodent-better-protein-creation/comment-page-1#comment-222846
ohMMThu, 03 Oct 2013 21:48:17 +0000http://www.kurzweilai.net/?p=208537#comment-222846...and you do realize each cell has more than just 1 or 2 mitochondria / ribosomes, right? :-)
you'll need more like quadrillions or quintillions of them.. But I admit I'm being a little pedantic now.
I'm not making fun of you.. much less laughing at you. I think you may "esteem" 'sapiens' too much.. are you a 'transapiens' or what? :-)…and you do realize each cell has more than just 1 or 2 mitochondria / ribosomes, right? :-)

you’ll need more like quadrillions or quintillions of them.. But I admit I’m being a little pedantic now.

I’m not making fun of you.. much less laughing at you. I think you may “esteem” ‘sapiens’ too much.. are you a ‘transapiens’ or what? :-)

]]>By: Brihttp://www.kurzweilai.net/the-secret-of-longevity-for-the-worlds-longest-living-rodent-better-protein-creation/comment-page-1#comment-222821
BriThu, 03 Oct 2013 21:27:46 +0000http://www.kurzweilai.net/?p=208537#comment-222821Cracked iPhone. The h an g are the center of the spider web. Too much money to fix. I was hoping that the new one would impress me, but I'm probably going to get a samsung. Laugh all you like. Even Amara teases me about it. I could care less. It is what it is. Making fun of it doesn't diminish my esteem for either of you. I think it's comical too. I tell all my friends and clients that I have a special iPhone, with a spiderman logo.Cracked iPhone. The h an g are the center of the spider web. Too much money to fix. I was hoping that the new one would impress me, but I’m probably going to get a samsung. Laugh all you like. Even Amara teases me about it. I could care less. It is what it is. Making fun of it doesn’t diminish my esteem for either of you. I think it’s comical too. I tell all my friends and clients that I have a special iPhone, with a spiderman logo.
]]>By: ohMMhttp://www.kurzweilai.net/the-secret-of-longevity-for-the-worlds-longest-living-rodent-better-protein-creation/comment-page-1#comment-222820
ohMMThu, 03 Oct 2013 21:16:20 +0000http://www.kurzweilai.net/?p=208537#comment-222820* tHe powerhouses. :-)* tHe powerhouses. :-)
]]>By: Brihttp://www.kurzweilai.net/the-secret-of-longevity-for-the-worlds-longest-living-rodent-better-protein-creation/comment-page-1#comment-222815
BriThu, 03 Oct 2013 20:54:14 +0000http://www.kurzweilai.net/?p=208537#comment-222815My bad. I meant ribosome. They are the factories. Mitochondria are Tge powerhouses.My bad. I meant ribosome. They are the factories. Mitochondria are Tge powerhouses.
]]>By: ohMMhttp://www.kurzweilai.net/the-secret-of-longevity-for-the-worlds-longest-living-rodent-better-protein-creation/comment-page-1#comment-222814
ohMMThu, 03 Oct 2013 20:51:27 +0000http://www.kurzweilai.net/?p=208537#comment-222814Of course, Mr.X! How else to explain women, which are beautiful, not simply denying to reproduce with men, which are hideous. There are diminishing returns after certain amount of, let's call it, discernment. ;-)Of course, Mr.X! How else to explain women, which are beautiful, not simply denying to reproduce with men, which are hideous. There are diminishing returns after certain amount of, let’s call it, discernment. ;-)
]]>By: ohMMhttp://www.kurzweilai.net/the-secret-of-longevity-for-the-worlds-longest-living-rodent-better-protein-creation/comment-page-1#comment-222812
ohMMThu, 03 Oct 2013 20:44:16 +0000http://www.kurzweilai.net/?p=208537#comment-222812Problems again with your utterances, Bri. You mean the "ribosome".Problems again with your utterances, Bri. You mean the “ribosome”.
]]>By: johhny ventishttp://www.kurzweilai.net/the-secret-of-longevity-for-the-worlds-longest-living-rodent-better-protein-creation/comment-page-1#comment-222763
johhny ventisThu, 03 Oct 2013 20:08:46 +0000http://www.kurzweilai.net/?p=208537#comment-222763How can humans duplicate this process in our bodies?How can humans duplicate this process in our bodies?
]]>By: eldrashttp://www.kurzweilai.net/the-secret-of-longevity-for-the-worlds-longest-living-rodent-better-protein-creation/comment-page-1#comment-222762
eldrasThu, 03 Oct 2013 20:02:48 +0000http://www.kurzweilai.net/?p=208537#comment-222762This is obviously important, but we still need machine intelligence to understand human biocomplexity.
Why do mistakes occur AT ALL in copying. There are no such things as mistakes in a deterministic system:
The issue is measurement and for that we need datum observer machines then powerful calculators.This is obviously important, but we still need machine intelligence to understand human biocomplexity.

Why do mistakes occur AT ALL in copying. There are no such things as mistakes in a deterministic system:

The issue is measurement and for that we need datum observer machines then powerful calculators.

]]>By: ohMMhttp://www.kurzweilai.net/the-secret-of-longevity-for-the-worlds-longest-living-rodent-better-protein-creation/comment-page-1#comment-222746
ohMMThu, 03 Oct 2013 19:20:15 +0000http://www.kurzweilai.net/?p=208537#comment-222746haha, nice way to put it, only the young die good looking =D
except for mole rats of course!haha, nice way to put it, only the young die good looking =D

except for mole rats of course!

]]>By: Brihttp://www.kurzweilai.net/the-secret-of-longevity-for-the-worlds-longest-living-rodent-better-protein-creation/comment-page-1#comment-222665
BriThu, 03 Oct 2013 17:11:29 +0000http://www.kurzweilai.net/?p=208537#comment-222665I think it's more of " whatever doesn't kill you makes you stronger.". Being underground is responsible for their handsome features. The stresses from that environment has evolved the unusual mitochondria. Upgrading our mitochondria should, if anything, increase our human good looks. We would be remarkably healthy. Not to mention increased endurance. The mitochondria is the 3D printer of the cellular world. Out of those, the mole rats have the Mac Daddy 3D printer. Sign me up for a couple of trillion of them!I think it’s more of ” whatever doesn’t kill you makes you stronger.”. Being underground is responsible for their handsome features. The stresses from that environment has evolved the unusual mitochondria. Upgrading our mitochondria should, if anything, increase our human good looks. We would be remarkably healthy. Not to mention increased endurance. The mitochondria is the 3D printer of the cellular world. Out of those, the mole rats have the Mac Daddy 3D printer. Sign me up for a couple of trillion of them!
]]>By: Mr.Xhttp://www.kurzweilai.net/the-secret-of-longevity-for-the-worlds-longest-living-rodent-better-protein-creation/comment-page-1#comment-222651
Mr.XThu, 03 Oct 2013 16:47:28 +0000http://www.kurzweilai.net/?p=208537#comment-222651@Gator(+ohMM)
"Lets expect there are some side-effects of stealing longer life that must go with it, but hard to know until they try some more experiments…"
Yeah, many things in organisms that seem clearly suboptimal are often that way because of trade-offs.One example is intelligence in humans, where some strong interventions via noo-tropics (biochemistry of the brain, producing certain hormones in larger quantity, if I remember correctly) require you to consume certain supplements containing micro-nutrients that you wouldn't consume to that extent via regular food (not even today!), and which are needed for other important biological functions.So, there is a ceiling which today wouldn't have to exist anymore, given the availability of nutritional supplements.
But who knows what else comes into play?Millions of years of evolution make it seem likely that the value of intelligence to evolutionary fitness must be subject to some point of diminishing returns.Else there would probably more intelligent beings out there, both in quantity and quality.
The distinction between "absolute perfectness" and pareto-optimality comes to mind.Sometimes I call it the distinction between a mathematician's perfection and an engineer's perfection (makes more sense in my language I guess).
One simple model would be to think of adaptions as requiring costs.I once played a little game in which you could guide a creature through some time-based scenarios, starting with a single cell.In that game your avatar consumed other creatures to gain "points," often after battling them on a limited area.You could then invest those points in body parts (etc), which changed your attributes and abilities.After allocating your points time passed and you were "arrived" in a different era.
Also, concerning intelligence or longevity:
Afaik overspecialization (remember the cost of adaption) is the single greatest faktor contributing to the extinction of species.@Gator(+ohMM)
“Lets expect there are some side-effects of stealing longer life that must go with it, but hard to know until they try some more experiments…”

Yeah, many things in organisms that seem clearly suboptimal are often that way because of trade-offs.One example is intelligence in humans, where some strong interventions via noo-tropics (biochemistry of the brain, producing certain hormones in larger quantity, if I remember correctly) require you to consume certain supplements containing micro-nutrients that you wouldn’t consume to that extent via regular food (not even today!), and which are needed for other important biological functions.So, there is a ceiling which today wouldn’t have to exist anymore, given the availability of nutritional supplements.

But who knows what else comes into play?Millions of years of evolution make it seem likely that the value of intelligence to evolutionary fitness must be subject to some point of diminishing returns.Else there would probably more intelligent beings out there, both in quantity and quality.

The distinction between “absolute perfectness” and pareto-optimality comes to mind.Sometimes I call it the distinction between a mathematician’s perfection and an engineer’s perfection (makes more sense in my language I guess).

One simple model would be to think of adaptions as requiring costs.I once played a little game in which you could guide a creature through some time-based scenarios, starting with a single cell.In that game your avatar consumed other creatures to gain “points,” often after battling them on a limited area.You could then invest those points in body parts (etc), which changed your attributes and abilities.After allocating your points time passed and you were “arrived” in a different era.

Also, concerning intelligence or longevity:
Afaik overspecialization (remember the cost of adaption) is the single greatest faktor contributing to the extinction of species.

]]>By: GatorALLinhttp://www.kurzweilai.net/the-secret-of-longevity-for-the-worlds-longest-living-rodent-better-protein-creation/comment-page-1#comment-222639
GatorALLinThu, 03 Oct 2013 16:05:00 +0000http://www.kurzweilai.net/?p=208537#comment-222639http://www.youtube.com/watch?v=NJBoHa3GArA
Only the Good (looking) die young... LOL Yeah, you have to wonder how much of their mole rat good looks come from being underground, or lack of hair, big teeth, etc. Maybe they can just steal the long life gene and move it to pretty mice next.... Lets expect there are some side-effects of stealing longer life that must go with it, but hard to know until they try some more experiments...http://www.youtube.com/watch?v=NJBoHa3GArA

Only the Good (looking) die young… LOL Yeah, you have to wonder how much of their mole rat good looks come from being underground, or lack of hair, big teeth, etc. Maybe they can just steal the long life gene and move it to pretty mice next…. Lets expect there are some side-effects of stealing longer life that must go with it, but hard to know until they try some more experiments…

]]>By: ohMMhttp://www.kurzweilai.net/the-secret-of-longevity-for-the-worlds-longest-living-rodent-better-protein-creation/comment-page-1#comment-222588
ohMMThu, 03 Oct 2013 14:45:35 +0000http://www.kurzweilai.net/?p=208537#comment-222588That is also why they are so pretty! I'll stick to the "dying young" idea ;-)That is also why they are so pretty! I’ll stick to the “dying young” idea ;-)
]]>By: GatorALLinhttp://www.kurzweilai.net/the-secret-of-longevity-for-the-worlds-longest-living-rodent-better-protein-creation/comment-page-1#comment-222553
GatorALLinThu, 03 Oct 2013 12:40:18 +0000http://www.kurzweilai.net/?p=208537#comment-222553For now, I think they should focus on trying to steal some code from the Naked Mole Rats and give to regular mice to see if they can dramatically extend the max lifespan of the Mouse (then give to us humans). In that process they can win this prize http://www.mprize.org/?pn=mj_mprize_learnFor now, I think they should focus on trying to steal some code from the Naked Mole Rats and give to regular mice to see if they can dramatically extend the max lifespan of the Mouse (then give to us humans). In that process they can win this prize http://www.mprize.org/?pn=mj_mprize_learn
]]>By: GatorALLinhttp://www.kurzweilai.net/the-secret-of-longevity-for-the-worlds-longest-living-rodent-better-protein-creation/comment-page-1#comment-222552
GatorALLinThu, 03 Oct 2013 12:36:43 +0000http://www.kurzweilai.net/?p=208537#comment-222552Copied from your earlier article on "A hidden genetic code for better designer genes": http://www.kurzweilai.net/a-hidden-genetic-code-for-better-designer-genes
The results showed clearly that RNA folding, not rare codons, controlled protein production, and that scientists can increase protein production by altering folding, Goodman said. The new method could help resolve other thorny debates in molecular biology. “The combination of high-throughput synthesis and next-gen sequencing allows us to answer big, complicated questions that were previously impossible to tease apart,” Church said.
It seems the folding or the copying process is critical to have a cleaning method built in or some way to avoid errors that sneak in over time. We just need Xerox to fund these studies.... LOL or better learn how a copy of a copy of a copyy of a coopy can be put back to the original to make it last longer. Ironically Cancer or tumors are mistakes in the copy code and healing process that gets in a mistake that won't turn itself off and keeping making more of itself, thus creating the problem ironically when fixing it. I love that they use Nature to find what animals (Naked Mole Rat) have a better internal system already at work, then understand what is different and see if/how we can learn from that and copy it to other areas.
Maybe what they are learning about stem cells and how they can turn them into any cell, and how they can reprogram them helps avoid the copy of a copy problem? If you can go back to the original instead, maybe this helps avoid errors that sneak in over time with enough copies? http://www.kurzweilai.net/stem-cell-reprogramming-made-easierCopied from your earlier article on “A hidden genetic code for better designer genes”: http://www.kurzweilai.net/a-hidden-genetic-code-for-better-designer-genes

The results showed clearly that RNA folding, not rare codons, controlled protein production, and that scientists can increase protein production by altering folding, Goodman said. The new method could help resolve other thorny debates in molecular biology. “The combination of high-throughput synthesis and next-gen sequencing allows us to answer big, complicated questions that were previously impossible to tease apart,” Church said.

It seems the folding or the copying process is critical to have a cleaning method built in or some way to avoid errors that sneak in over time. We just need Xerox to fund these studies…. LOL or better learn how a copy of a copy of a copyy of a coopy can be put back to the original to make it last longer. Ironically Cancer or tumors are mistakes in the copy code and healing process that gets in a mistake that won’t turn itself off and keeping making more of itself, thus creating the problem ironically when fixing it. I love that they use Nature to find what animals (Naked Mole Rat) have a better internal system already at work, then understand what is different and see if/how we can learn from that and copy it to other areas.

Maybe what they are learning about stem cells and how they can turn them into any cell, and how they can reprogram them helps avoid the copy of a copy problem? If you can go back to the original instead, maybe this helps avoid errors that sneak in over time with enough copies? http://www.kurzweilai.net/stem-cell-reprogramming-made-easier