7 The role of the IGF/IGF -1R pathway, hsp90 and the proteasome for therapeutic targeting of these interactions C.S. Mitsiades Triggering cross-talks between plasma cells and the microenvironment F. Caligaris Cappio Role of RANKL and Osteoprotegerin in the pathophysiology of Multiple Myeloma N. Giuliani COFFEE BREAK SESSION IV ROLE OF IMMUNOSURVEILLANCE Chairmen: P. Coser, Q. Yi Role of glycolipid antigens and NK T cells in Myeloma M. Dhodapkar Natural and adaptive Idiotype-reactive T cells: application of various techniques for detection H. Mellstedt Role of mevalonate metabolites and gamma/delta T cells M. Massaia The role of T cells in Myeloma D.E. Joshua April 22, 7

16 REGISTRATIONS Registrations can only be accepted and confirmed after the registration form and fee have been received by the Organizing Secretariat, Studio E.R. Congressi. All payments must be done in Euro net of all bank charges and made out to Studio E.R. Congressi Srl. Please, pay by: - Eurocheque or Foreign Cheque - Bank transfer made out to Studio E.R. Congressi Srl Account n Cassa di Risparmio di Cesena - Agenzia n Largo Caduti del Lavoro 1/A Bologna, Italy Swift code CECRIT IBAN IT36J - ABI CAB CIN J - Credit Card Please send a copy of the bank transfer with the registration form. In case of written cancellation before March 1st, 80% of the registration fee will be refunded. HOTEL RESERVATIONS CO.AL.PI. Hotel Reservation Via Gioberti Torino - Italy Tel Fax RESERVATION CATEGORY ROOM TYPE PRICES 4 STARS Single Euro 171,00 Double Euro 229,00 Double Single Use Euro 203,00 3 STARS Single Euro 109,00 Double Euro 150,00 Double Single Use Euro 128,00 Rates are net, per room/per night, including bed and breakfast treatment and taxes. Please fill in the hotel reservation form and send it to CO.AL.PI. HOTEL RESERVATION within March 1st. Hotel reservations can only be accepted when the form has been received by the hotel reservation agency. Any hotel reservation will be confirmed by Co.Al.Pi. through a Confirmation Form with a specific Confirmation Number. No reservation is confirmed before receiving the Confirmation Number. All reservations have to be guaranteed by a credit card. In case of non-availability of the credit card, a confirmatory deposit (first night stay amount for any room booked) will be requested within 15 days before arrival. In case of no-show or of written cancellation of the reservation within 48 hours before the arrival, the hotel will charge one night penalty for any cancelled room. Full payment (including extra, if any) must be settled directly to the hotel upon check out. 16

17 SCIENTIFIC INFORMATION SCIENTIFIC SECRETARIAT Benedetto Bruno Massimo Massaia Paola Omedè Antonio Palumbo Divisione Universitaria di Ematologia Ospedale San Giovanni Battista di Torino Via Genova, Torino - Italy SLIDE Slides must be in English. Computer videoprojection will be available. Other requirements should be communicated to the Organizing Secretariat as soon as possible. Slides should be handed to the slide center one hour before the beginning of the session and collected at the end. BADGE All registered participants, speakers and exhibitors will be given a badge which they must wear to be admitted to the scientific sessions. ATTENDANCE CERTIFICATE A certificate will be given to all participants at the end of the Meeting. ECM Application for ECM credits has been made. CHANGES Parts of the program may be changed if necessary. Multiple Myeloma 17

20 PAYMENT c c c I enclose Eurocheque or Foreign Cheque of Euro Number Bank made out to Studio E.R. Congressi Srl Bank transfer made out to Studio E.R. Congressi Srl Account n Cassa di Risparmio di Cesena Agenzia n Largo Caduti del Lavoro 1/A Bologna, Italy Swift code CECRIT IBAN IT36J - ABI CAB CIN J Credit card: Number c c c c c c cc c cc c c c c c Expiry date Owner Date of birth c VISA c MASTERCARD c DINERS c AMERICAN EXPRESS I enclose a copy of the bank transfer with the registration form. Registrations can only be accepted and confirmed when the registration form and fee have been received by the Organizing Secretariat Studio E.R. Congressi. In case of written cancellation before March 1st, 80% of the registration fee will be refunded. Signing this form and well informed on the Law n. 675 Dec. I, 1996 concerning personal data processing particulary on the articles 10, 20, 24 and 28. I authorize Studio E.R. Congressi S.r.L., until written revocation, to process and divulge my personal data within the limits at the above-mentioned law and in accordance with the procedure laid down by the law. I give my assent provided that Studio E.R. Congressi complies with the regulation in force. c I do not want that my personal data are divulged to third parties. Date Signature 20

23 Information on Law n. 675 a. Your personal data written in this form together with spoken data given later during the congresses organized or promoted by us will be employed by Studio E.R. Congressi S.r.l. for managing, accounting, statistical, commercial, marketing and/or promoting purposes and this by processing, comparing, divulging or employing these very data. b.to be registered in the congresses we organize, you are obliged to give your data. c. Your data can be given the organizers of the congress, the companies sponsoring the event as well as to other companies, authorities, consortia or associations that could divulge these data to their members, users and other related people within the limits of their institutional purposes. The only objective is to inform the person concerned about the existence of similar initiatives or to supply him with other information that could be deemed interesting. d. Furthermore, the above mentioned data can be given/divulged to companies, authorities, consortia or associations working in Italy or in the EC countries having the same objective as stated in the previous paragraph. e. Data will be processed by appropriate devices ensuring their security and confidentiality. Data could be also processed by automatic machines employed to process, store and transmit the very data. As to the above mentioned data processig, Studio E.R. Congressi S.r.l. must without delay: a. confirm to the person concerned the existence of his/her personal data, even if they have not been stored yet, purvey these data and their origin in a form which is readily comprehensible, specify the logic the data processing is based on. Unless for justified reasons, this request can be submitted again at least 90 days after the first submission; b.delete, render anonymous or stop the flowing of those data - all data related to the person concerned processed in violation of the law; c. update, rectify or, upon request of the person concerned, complete the integration of these data; d. certify that all companies, associations etc. provided with these data have been informed of what is specified in the paragraphs b) and c) - unless the means employed to inform them are disproportionate. The person concerned has the right to know - consulting the register specified in the art. 31, sub-section 18, letter a) of the law n. 675, Dec. 31, the existence of data processing; he/she can partially or entirely oppose, for legitimate reasons, the processing of his/her data, even if these data are relevant to the objective of data collection. Furthermore he can prevent his/her data from being used for commercial purposes, market surveys, advertisement for direct selling or interactive commercials. 23

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