Kinetex® 1.7 µm Core-Shell Columns

1.7 µm Kinetex core-shell particles are the first and only sub-2 µm core-shell particle on the market and produce the highest efficiencies of any sub-2 µm column on the market.
The secret is in the core-shell particle morphology. A uniform porous silica layer is grown on top of a solid silica core. This precise architecture results in a nearly monodispersed sub-2 µm particle that is at the fo...read more

"I developed the method and validated it with three different batches of 1.7 µm columns. It was performed on two different HPLC systems and three different analysts. Everything looked fantastic with the lowest USP resolution of the 10 peaks of 3.0 in all runs. The robustness testing showed that I could change pH and acetonitrile concentration in a wide range without any significant loss of resolution. The method is transferred to QC (in another country) without any problems. They buy a large number of columns for the process validation. Only a few works. Peaks are split or very broad. They record the backpressure (very good, 20% less than other competitors)."

"I have been using several HPLC columns for purification of peptides and peptidomimetics synthesis in my lab and I have never had in my hands a column with such simplicity in its use and endowed with high efficiency! I am using this column for the purification of several kinds of peptides, linear, cyclic and peptidomimetics with great satisfaction!"

"I bought the Kinetex column for developing LC/MS screening method for drugs of abuse in biological samples. The separation of the compounds of interest is excellent on this column in comparison to the previous column I was using for the same method. The efficiency and plate count for the compound of interest is higher than other sub-2um columns that I have tried. Due to the success of this column I achieved, I will definitely consider this column as my choice for developing new methods in the future. "

"I used this Kinetex column in my pharmacokinetics study. After using this column in my high performance liquid chromatography coupled with electrochemical detection, I felt that this column had the better separation and good reproducibility and the sensitivity is good. However, when I did my study, I had some problems. Because my study is about pharmacokinetic with microdialysis technique, my samples include a lot of salts. I felt that the reservation is very important. I usually clean my column with 10% methanol first and then with 50% methanol. It usually took a lot of time to clean the column."

"This column is very much in use in our pharmaceutical laboratory. We use it every day because its efficiency is excellent. The analyses are very short and quick. Its practical use is in reverse phase chromatography and it tolerates organic solvents in sample preparation too. The sales people from Chromservis company are very friendly and can be reached by phone every day. The price of the column is relatively good, however it could be much cheaper. We are very successful with it."

"The column is very user friendly. The efficiency of the column is excellent. After sales service is very good. The price of column is relatively good but could be cheaper. I would recommend this column to my colleagues because this column gives very good results, excellent separations of small particulates and high efficiency. We analyze most samples on it."

"We have been using this column for over a year now and have had no problem with it whatsoever. It produces very reliable and repeatable chromatograms and is very robust. Though it is a bit expensive I would definitely recommend for anyone looking for a reliable column."

"The Kinetex Core-Shell UHPLC Columns are great for high efficiency and fast separations. One great advantage of this product is that it allows the analyst to have all the benefits of small particles without paying the cost of extreme backpressures."

"The column ensures access to UPLC separation with existing HPLC devices. The support from Phenomenex is excellent for the development of analytical HPLC methods in the field of pharmaceutical small molecules. Several methods have been developed using the 1.7micron particle column. We were able to use HPLC equipment for the UPLC separation, additionally UPLC separation on UPLC system was employed easily. The method has been considered as robust and excellent."

"Easy to use and provides excellent separations for USP monograph modernization work. Currently USP is modernizing several outdated assay and impurity methods with modern technologies like UHPLC and capillary GC techniques."

"Kinetex Columns (various particle sizes) are a great tool in separation science. They allow the analyst to perform very fast separations using traditional column back-pressures. Excellent peak shape and efficiency. I have given a neutral score of 3 for after sales service as it was not applicable."

"We use this column at the front end of our LC/MS system and it has worked well for a range of small molecules including fatty acids, lipids (PC, PE, PG), chitosan, aromatics etc. I would highly recommend these columns."

Description

1.7 µm Kinetex core-shell particles are the first and only sub-2 µm core-shell particle on the market and produce the highest efficiencies of any sub-2 µm column on the market.

The secret is in the core-shell particle morphology. A uniform porous silica layer is grown on top of a solid silica core. This precise architecture results in a nearly monodispersed sub-2 µm particle that is at the forefront of UHPLC technology and challenging system manufacturers to develop next generation UHPLC systems capable of taking full advantage of the performance offered.