ONCO.IO database content is based on the manually curated annotation of experimentally verified molecular interactions described in the literature and includes microRNAs, lncRNAs, mRNAs, signaling proteins and transcription factors interactions.

Key features:

Self-designed ontology of cancer pathogenic processes (PPs) based on the R.A. Weinberg’s hallmarks of cancer

Network analysis interactive tools

Search term and build network:

Pathogenic process (PP) - molecular, cellular or tissue malfunction determining initiation, development and outcome of disease. Full list of PP is here
Interactions (or edges) are associated with pathogenic process and can influence as positively and negatively on the process.

Genes and ncRNAs

News:

Thanks to our visitors!26 July 2019 16:25:13 by Sasha FokinWe thank the anonymous guest for pointing out the vulnerabilities. They are was patched, but there is still much to be done, and we are gradually completing it.
While the project is running in the background.

miRs in prostate cancer: comlex regulatory connections with cancer hallmarks 18 January 2019 23:53:17 by Rhizoman1Next week we will annotate regulatory interactions in prostate cancer. Prostate cancer (PCa) is considered the most prevalent malignancy and the second major cause of cancer-related death in males from Western countries. Androgen deprivation therapy (ADT) is the primary treatment option for male patients with advanced symptomatic PCa. Castration-resistant prostate cancer (CRPC) refers to the continuous progression of PCa following ADT. We will focus on the role of non-coding RNAs and transcription factors in prostate cancer development and progression.

Paywall: The Business of Scholarship26 December 2018 16:17:32 by Sasha FokinPaywall: The Business of Scholarship is a documentary which focuses on the need for open access to research and science, questions the rationale behind the $25.2 billion a year that flows into for-profit academic publishers, examines the 35-40% profit margin associated with the top academic publisher Elsevier and looks at how that profit margin is often greater than some of the most profitable tech companies like Apple, Facebook and Google.

The program of reduce the critical dependence of Russian science on foreign genetic and biological databases. 26 December 2018 16:10:04 by Sasha Fokin"The Ministry of Education and Science proposes to allocate 220.5 billion rubles. on the development of genetic technologies in the framework of the federal scientific and technical program for the years 2019-2027.
This is stated in the draft government decree on the approval of the program, published on Friday on the federal portal of draft regulations. The implementation of the program is designed to "reduce the critical dependence of Russian science on foreign genetic and biological data bases, foreign specialized software and devices, the programs passport says. In Russia, bioinformatics and genetic databases, basic reagents and software products and equipment prototypes should be created."
The leading scientific organization will be the Kurchatov Institute. The ONCO.IO is made entirely by our forces and means without the help of any other structures and organizations. This is a completely independent product. For all inhabitants of the planet Earth, we provide equal access to ONCO.IO and his services.

Immune response interactome! 06 October 2018 01:24:29 by Rhizoman1T-cell-DC, signaling and regulatory pathways that develop immune response. Co-regulatory and repressor molecules. Receptors, signaling molecules, transcription factors as are drivers of anti-cancer immunity. Next week we will annotate immunoregulatory interactome! This is dedicated to the Nobel prize in Physiology or Medicine 2018!

NRF2 and TRIM proteins , where is conection?17 September 2018 00:15:16 by Rhizoman1In addition to NRF2 interactome we will integrate TRIM proteins interactome! TRIM (Tripartite motif (TRIM) proteins) are a versatile family of ubiquitin E3 ligases
involved in a multitude of cellular processes. Oxidative stress and aniviral response)