About this book

Introduction

Wilma Wasco and Rudolph Tanzi bring together in Molecular Mechanisms of Dementia the best and latest thinking by leading scientists on the etiologic and pathogenic events responsible for the onset of Alzheimer's disease and related dementias. In presenting the various mechanisms and multifaceted approaches currently being employed, the distinguished contributors review such critical factors as apoptosis, energy metabolism, excitotoxicity and calcium-mediated cell death, free radicals, electrophysiological abnormalities, environmental toxins, degeneration of neural networks, and modification of the cytoskeleton. They also examine mechanisms by which ischemia and hypoxia result in dementia.

Molecular Mechanisms of Dementia is the first major contemporary review of this dramatically advancing field. It provides an invaluable summary of the tremendous progress that has been made in developing testable models of the molecular mechanisms of dementia, as well as critical insights into the necessary direction of future investigations of dementia. The book is certain to become a standard reference for all researchers now working in the field of neurodegenerative disorders.