In the Shadow of the Moon revolves around a story in which a series of strange deaths occurs in unison at various points in the city of Philadelphia. All of them have been produced without apparent signs of violence, have bled to death, with the brain liquefied and the bodies have puncture marks on the neck. Police officer Thomas Lockhart ( Boyd Holbrook ) with his brother-in-law, Detective Holt ( Michael C. Hall ) begin the investigation behind the trail of a murderer who seems to have at his disposal unknown technology and even the ability to travel through weather.