Hello. I am a new member. I have had total colonic dysmotility for over 10 years now. I was on Go-litely and then Miralax every night. I have to use 1 and 1/2 caps of Miralax every night. I had my Gallbladder removed, and as a result of the surgery, my colon,large intestine, has no nerves. I feel like the Miralax is not working well. I really do not want to have the colon removed. Would like to hear from others that live with this problem. I also now have Rheumatoid Arthritis and Pustular Psoriasis. Looking forward to hearing from you. Kathyann