The news that the "Thelma & Louise" actress is slated to grace the halls of Grey Sloan Memorial Hospital comes after major character Dr. Cristina Yang, played by Sandra Oh, left the long-running drama after 10 years last season.

The show's creator, Shonda Rhimes, is truly dominating Thursdays this fall as "Grey's," "Scandal" and newcomer "How To Get Away With Murder" (all produced by Rhimes) will air back to back on the same night.