BCG growth variation can modulate the immune response to BCG

In Guinea-Bissau we found that during a period when the manufacturer experienced slow growth rate of the BCG vaccine, the BCG vaccine was actually much better at inducing a BCG scar and a positive tuberculin skin test response.

Updated 1 April 2015

These indicators are all positively associated with improved survival in childhood. Hence, variations in the production of BCG vaccine may influence important immunological effects of the vaccine

Biering-Sørensen S, et al. Variation of growth in the production of
the BCG vaccine and the association with the immune response. An observational
study within a randomised trial. Vaccine. 2015 Mar 10. pii:
S0264-410X(15)00245-5. doi: 10.1016/j.vaccine.2015.02.056.

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