______________________________PRODUCTRecovered Plasma, Recall # B-1299-6 CODEUnit: 4357117 RECALLING FIRM/MANUFACTURERDepartment of the Navy, Naval Medical Center, San Diego, CA, by fax and letter on September 25, 2003. Firm initiated recall is complete. REASONBlood product, collected from a donor considered to be at risk of exposure to Creutzfeldt-Jacob Disease (CJD), was distributed.VOLUME OF PRODUCT IN COMMERCE1 unitDISTRIBUTIONGermany

with new atypical TSE in the bovine, in the sheep, goat, and humans, and the fact that the new BASE TSE in cattle being very very similar to sporadic CJD, rather than the nvCJD, the fact that now science showing the TSE agent of the atypical cattle in Japan showing infectivity other than CNS tissue, the fact that the latest Texas mad cow and the recent Alabama mad cow both being of the atypical strain, it would seem prudent to include all human TSE in the blood ban, in my opinion. ...

SEE STEADY INCREASE IN SPORADIC CJD IN THE USA FROM1997 TO 2004. SPORADIC CJD CASES TRIPLED, and that iswith a human TSE surveillance system that is terribleflawed. in 1997 cases of the _reported_ cases of cjdwere at 54, to 163 _reported_ cases in 2004. see statshere;

AS implied in the Inset 25 we must not _ASSUME_ thattransmission of BSE to other species will invariablypresent pathology typical of a scrapie-like disease.

snip...

http://www.bseinquiry.gov.uk/files/yb/1991/01/04004001.pdf

ATYPICAL TSEs in USA CATTLE AND SHEEP ?

http://www.bseinquiry.gov.uk/files/sc/seac17/tab03.pdf

Infected and Source Flocks

As of August 31, 2005, there were 115 scrapie infectedand source flocks (figure 3). There were 3 new infectedand source flocks reported in August (Figure 4) with atotal of 148 flocks reported for FY 2005 (Figure 5).The total infected and source flocks that have beenreleased in FY 2005 are 102 (Figure 6), with 5 flocksreleased in August. The ratio of infected and sourceflocks released to newly infected and source flocks forFY 2005 = 0.69 :1. In addition, as of August 31, 2005, 574 scrapiecases have been confirmed and reported by the NationalVeterinary Services Laboratories (NVSL), of which 122were RSSS cases (Figure 7). This includes 55 newlyconfirmed cases in August 2005 (Figure 8). Fifteencases of scrapie in goats have been reported since 1990(Figure 9). The last goat case was reported in May 2005.

Edited by Stanley B. Prusiner, University ofCalifornia, San Francisco, CA, and approved September12, 2005 (received for review March 21, 2005)

Scrapie in small ruminants belongs to transmissiblespongiform encephalopathies (TSEs), or prion diseases,a family of fatal neurodegenerative disorders thataffect humans and animals and can transmit within andbetween species by ingestion or inoculation. Conversionof the host-encoded prion protein (PrP), normalcellular PrP (PrPc), into a misfolded form, abnormalPrP (PrPSc), plays a key role in TSE transmission andpathogenesis. The intensified surveillance of scrapiein the European Union, together with the improvement ofPrPSc detection techniques, has led to the discovery ofa growing number of so-called atypical scrapie cases.These include clinical Nor98 cases first identified inNorwegian sheep on the basis of unusual pathologicaland PrPSc molecular features and "cases" that produceddiscordant responses in the rapid tests currentlyapplied to the large-scale random screening ofslaughtered or fallen animals. Worryingly, asubstantial proportion of such cases involved sheepwith PrP genotypes known until now to confer naturalresistance to conventional scrapie. Here we report thatboth Nor98 and discordant cases, including three sheephomozygous for the resistant PrPARR allele(A136R154R171), efficiently transmitted the disease totransgenic mice expressing ovine PrP, and that theyshared unique biological and biochemical features uponpropagation in mice. These observations support theview that a truly infectious TSE agent, unrecognizeduntil recently, infects sheep and goat flocks and mayhave important implications in terms of scrapie controland public health.