The early Greek historian Ctesias c. 400 BCE (followed by Diodorus Siculus) alleged that the legendary Assyrian king Ninus had defeated a Bactrian king named Oxyartes in ca. 2140 BC, or some 1000 years before the Trojan War. Ever since the discovery of cuneiform enabled actual Assyrian records to be deciphered in the 19th century, however, historians have ascribed little value to the Greek account.

It is suggested by E. Herzfeld that Bactria once belonged to the Median empire.[7] It was annexed by the Achaemenid Persians in the 6th century BCE and together with Margiana it formed the twelfth satrapy of the Achaemenids.[8] After Darius III of Persia was defeated by Alexander the Great and killed in the ensuing chaos, his murderer Bessus, the satrap of Bactria, tried to organize a national resistance based on his satrapie but was captured by other warlords and delivered to Alexander. He was then tortured and killed.[9]

Alexander the Great conquered Sogdiana and Persia. However, in the south, beyond the Oxus, he met strong resistance. After two years of war Bactria was occupied by the Macedonians, but Alexander never successfully subdued the people. After Alexander's death, the Macedonian Empire was eventually divided up between several generals in Alexander's army. Bactria became part of Seleucus I, the founder of the Seleucid Empire.

Gold stater of the Greco-Bactrian king Eucratides, the largest gold coin of Antiquity.

The Greco-Bactrians were so powerful that they were able to expand their territory as far as India:

"As for Bactria, a part of it lies alongside Aria towards the north, though most of it lies above Aria and to the east of it. And much of it produces everything except oil. The Greeks who caused Bactria to revolt grew so powerful on account of the fertility of the country that they became masters, not only of Bactria and beyond, but also of India, as Apollodorus of Artemita says: and more tribes were subdued by them than by Alexander...."[11]

The Greco-Bactrians used Greek language for administrative purposes, and the local Bactrian language was also Hellenized, as suggested by its adoption of the Greek alphabet and Greek loanwords. In turn, some of these words were also borrowed by modern Pashto, the language of Afghanistan.[12]

The treasure of the royal burial Tillia tepe is attributed to 1st century BCE Sakas in Bactria.

The weakness of the Greco-Bactrians was shown by its sudden and complete overthrow, first by the Sakas, and then by the Yuezhi (who later became known as Kushans), who had conquered Bactria by the time of the visit of the Chinese envoy Zhang Qian (circa 127 BCE), who had been sent by the Han emperor to investigate lands to the west of China.[13]

Under the Sassanids the province would become part of the area known as Khorasan.[4]

Kujula Kadphises, the Guishuang xihou (or prince) of the Da Yuezhi, united the region in the early 1st century and laid the foundations for the powerful, but short-lived, Kushan Empire (1st to 3rd century CE), which was then overcome by the Sassanians from Persia. The name Daxia appears in Chinese from the 3rd century BCE to designate a mythical kingdom to the West, possibly a consequence of the first contacts with the expansion of the Greco-Bactrian Kingdom, and then is used by the explorer Zhang Qian in 126 BCE to designate Bactria.

The reports of Zhang Qian were put in writing in the Shiji ("Records of the Grand Historian") by Sima Qian in the 1st century BCE. They describe an important urban civilization of about one million people, living in walled cities under small city kings or magistrates. Daxia was an affluent country with rich markets, trading in an incredible variety of objects, coming as far as Southern China. By the time Zhang Qian visited Daxia, there was no longer a major king, and the Bactrian were suzerains to the nomadic Yuezhi, who were settled to the north of their territory beyond the Oxus (Amu Darya). Overall Zhang Qian depicted a rather sophisticated but demoralized people who were afraid of war.

Following these reports, the Chinese Emperor Wu Di was informed of the level of sophistication of the urban civilizations of Ferghana, Bactria and Parthia, and became interested in developing commercial relationship with them:

"The Son of Heaven on hearing all this reasoned thus: Ferghana (Dayuan) and the possessions of Bactria (Daxia) and Parthia (Anxi) are large countries, full of rare things, with a population living in fixed abodes and given to occupations somewhat identical with those of the Chinese people, but with weak armies, and placing great value on the rich produce of China" (Hanshu, Former Han History).

These contacts immediately led to the dispatch of multiple embassies from the Chinese, which helped to develop the Silk Road.

The percentage of households with clean drinking water increased from 8% in 2005 to 15% in 2011.[14] The percentage of births attended to by a skilled birth attendant increased from 0% in 2005 to 20% in 2011.[14]

Around 66% of the population of Balkh lives in rural districts while 34% lives in urban areas. Around 51 % of the population is male and 49% is female. The major ethnic groups living in Balkh province are Tajiks and Pashtoons followed by Uzbek, Hazaras, Turkman, Arab and Baluch. Farsi is spoken by 50% of the population and 58% of the villages. The second most frequent language is Pashtu, spoken by the majorities in 266 villages representing 27% of the population, followed by Turkmani (11.9%) and Uzbeki (10.7%).
Balkh province also has a population of Kuchis or nomads whose numbers vary in different seasons. In winter 52,929 individuals, or 2.2% of the overall Kuchi population, stay in Balkh living in 80 communities. Half of these are short-range partially migratory, another third are long-range partially migratory, and 18% are settled. Overall, for long and short range migratory categories, less than half of the community migrates. In the winter both groups stay mostly in one area and don’t move around during the season. In the summer season, some 120 long range migratory Kuchi households come from Saripul province to Balkh province. The Kuchi population in the summer is 59,776 individuals.

Simorgh Alborz Logo. Alborz is the name of the local mountain range and Simorgh is a mythical bird in Dari Persian literature.

The locals of Balkh take great pride in their sporting history and culture. Every Nowruz (Persian New Year), Balkh is the site of many sporting events. Buzkashi is a traditional horse riding sport of the region and is very popular in this province. Pehlwani is also a popular sport in the province. However, the most popular presently and for the last 50 years has been Soccer, this was evident in the Balkh team Simorgh Alborz F.C. finishing runners up in the inaugural Afghan Premier League[17] and in their contributions to the National Team.