Cholinergics

While choline bitartrate benefits people using choline for their liver benefits, the research on this substance for cognitive performance and preventing cognitive decline is somewhat hit or miss. As you will see throughout this article, there may be better alternative…

Soy lecithin may be one of the most ubiquitous supplements for choline (and it is certainly the cheapest), but it is the least efficient and we would advise using a different type of choline source if that is your main…

One common source of choline is through a phospholipid molecule called phosphatidylcholine. As the name suggests, this is a phospholipid (fatty acid group) attached to a choline molecule and the combination is found throughout the body, but often supplemented with…

The uridine supplement (often in the form of uridine monophosphate), is a nucleotide that can improve neuronal growth in the brain [1], which suggests it enhances general cognitive function. The same synaptic growth can help uridine to treat symptoms of…

DMAE is structurally similar to choline, but has one less methyl group. This creates different properties that are said to improve memory and reduce signs of aging in the brain. While not statistically significant, there is some evidence to suggest…

Last edited: June 11, 2018 Centrophenoxine is primarily used as a precursor or prodrug for DMAE (dimethylaminoethanol), which helps to improve cognitive abilities in the elderly [1]. Although the primary use for centrophenoxine is with senile dementia and Alzheimer’s patients, many…

Last updated: May 1, 2018 The primary benefit and purpose of alpha GPC is as a prodrug for choline, which it is considered one of the (if not the) most efficient supplement for this purpose [1]. By providing your brain…

The CDP choline is a prodrug for choline and uridine. This is primarily useful for improving working memory and executive function [1], but many elderly use this compound to mitigate age related memory loss and neuronal decay [2]. Citicoline is…

Last updated: March 15, 2017 One of the few studies that exists shows incredible promise for the drug, though obviously requires more analysis. In this study, supplementation of PRL-8-53 improved memory formation 87.5 – 105%. Those over the age of 30 saw…