San Francisco, CA (Sports Network) - Roddy White caught two touchdowns and Michael Turner rushed for three more -- all in the first half -- as Atlanta jumped all over the 49ers and cruised to a 45-10 victory.

San Francisco (3-2) had allowed 16 points or less in three of its first four games, but Atlanta (3-1) scored a franchise record 35 first-half points en route to an emphatic road win.

White finished with a franchise-record 210 yards on eight receptions, while Turner rushed for 97 yards on 22 carries for the Falcons, who had an extra week to prepare after falling to the Patriots in Week 3.

Matt Ryan passed for a career-high 329 yards with two touchdowns and an interception on 22-of-32 efficiency while also rushing for a score in the lopsided win.

"We felt like we did a lot of things well today. There's some things we can do better, but we came out and accomplished what we wanted to accomplish," Falcons head coach Mike Smith said. "It was nice to see Roddy White have the kind of game he had...We all had fun today."

Glen Coffee rushed for San Francisco's only TD, totaling 45 yards on 12 carries. Shaun Hill connected on just 15-of-38 attempts for 198 yards with one interception for the 49ers, who were coming off a 35-0 whipping of the Rams.

The hosts didn't have the services of rookie wideout Michael Crabtree, who ended his lengthy holdout Wednesday but did not dress.

Hill's first pass of the game was picked off, and the Falcons, who went three- and-out on their opening possession, took over at the 49ers 21-yard line.

Turner's seven-yard touchdown run put the visitors on top, and after the defense forced a quick punt, Atlanta went up 14-0 when Ryan found White wide open in the end zone following a play-action fake from 31 yards out.

San Fran got a spark when Josh Morgan caught a pass, broke a tackle and went 61 yards down to the Atlanta two. On 3rd-and-goal from that spot, Coffee took a toss and crossed the goal line with 4:09 remaining in the first quarter.

Vernon Davis made an 18-yard catch on 4th-and-1 early in the second stanza, and Joe Nedney's 39-yard kick made it 14-10 with 11:07 left before halftime.

The hosts failed to convert Jerious Norwood's fumble into points a little later, proving costly. A punt pinned the Falcons deep in their own territory, but White turned a seemingly innocuous five-yard hook route into a 90-yard, highlight-reel TD down the left sideline.

Delanie Walker coughed up the ensuing kickoff, though replay showed the ground caused the fumble. With no timeouts remaining, the 49ers couldn't challenge the ruling, and Atlanta took over at the San Fran 38.

Turner's 33-yard scamper set up his own three-yard score, and the Atlanta running back capped a six-play, 54-yard drive with a one-yard plunge just before the break to take a commanding 35-10 edge.

The storyline stayed the same in the second half. Nedney missed a 48-yard field goal two minutes into the third quarter, and Dre Bly fumbled an interception away minutes later.

Jason Elam's 40-yard field goal was the only points scored in the third.

Atlanta held the ball for over 8 1/2 minutes in the fourth, and Ryan put the exclamation point on the 13-play, 76-yard march with a one-yard score off a bootleg to the right.

"Obviously in a game like this I think all of us [coaches] have to do a better job of preparing our guys," 49ers head coach Mike Singletary said. "We did not play very smart today...This was be a wake up call for some of our guys."

Game Notes

The 49ers have their bye next week, while Atlanta hosts the Bears...49ers safety Michael Lewis left the game in the third quarter with an apparent concussion...Atlanta's Tony Gonzalez had six catches for 55 yards and has caught a pass in 135 consecutive games...Hill, who had a team-high 53 rushing yards on four carries, lost his first home start (7-1), and the 49ers had a five-game home winning streak snapped...Morgan ended with four catches for 78 yards...The Falcons owned a 477-279 yardage advantage.