How temperature synchronizes the body clock

Published: Friday, October 30, 2009, 12:44 [IST]

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Washington, Oct 30 (ANI): A new study on the fruit-fly brain, conducted by scientists from Queen Mary, University of London, points to a possible mechanism by which temperature synchronizes the body clock (also known as the circadian clock).

A variety of organisms, including insects and humans, have evolved an internal circadian clock to regulate patterns of behaviour throughout the day - for example sleep, appetite, alertness and concentration.

Although much is known about how light affects the body clock, it is not well understood which cells or organs sense daily temperature changes or how temperature signals reach the part of the brain that contains the circadian clock.

"Given the substantial similarity between the fly and mammalian clock, our studies might also help to understand the human circadian clock and in the future perhaps contribute to developing treatments against the negative effects of sleep-disorders and shift-work," senior study author Dr Ralf Stanewsky, from Queen Mary's School of Biological and Chemical Sciences, as saying.

Specially evolved "clock cells" in the brain contain the circadian clock, which needs to be synchronised with the natural environmental cycles every day to prevent them running too fast or too slow.

Stanewsky and colleagues have shown that fly brains were unable to synchronize to temperature cycles when separated from the rest of the body.

This is in contrast with the ability to synchronize to light-dark cycles, which can take place with or without a connection to the fly body.

This study identified a gene called nocte that, when altered, interferes with the fly's ability to synchronize its body clock using temperature signals.

Importantly, disabling the nocte gene in nerve cells in the body also prevented the brain's ability to synchronize with temperature.