(1 of )San Francisco 49ers quarterback Alex Smith (11) against the Buffalo Bills during the first half of an NFL football game in San Francisco, Sunday, Oct. 7, 2012. (AP Photo/Tony Avelar)

(2 of )Buffalo Bills defensive end Mario Williams (94) against the San Francisco 49ers during the first half of an NFL football game in San Francisco, Sunday, Oct. 7, 2012. (AP Photo/Jeff Chiu)

(3 of )Buffalo Bills tight end Scott Chandler (84) catches a pass in front of San Francisco 49ers linebacker Patrick Willis (52) during the first half of an NFL football game in San Francisco, Sunday, Oct. 7, 2012. (AP Photo/Tony Avelar)

(4 of )Buffalo Bills wide receiver Brad Smith (16) runs against San Francisco 49ers linebacker Patrick Willis (52) during the second half of an NFL football game in San Francisco, Sunday, Oct. 7, 2012. (AP Photo/Tony Avelar)

(5 of )Buffalo Bills wide receiver Steve Johnson (13) is shown against the San Francisco 49ers during the first half of an NFL football game in San Francisco, Sunday, Oct. 7, 2012. (AP Photo/Ben Margot)

(6 of )San Francisco 49ers running back Kendall Hunter (32) runs against the Buffalo Bills during the second half of an NFL football game in San Francisco, Sunday, Oct. 7, 2012. (AP Photo/Tony Avelar)

(7 of )San Francisco 49ers running back Kendall Hunter (32) runs from Buffalo Bills strong safety Da'Norris Searcy (25) during the second half of an NFL football game in San Francisco, Sunday, Oct. 7, 2012. (AP Photo/Tony Avelar)

(8 of )San Francisco 49ers quarterback Alex Smith (11) warms up before an NFL football game against the Buffalo Bills in San Francisco, Sunday, Oct. 7, 2012. (AP Photo/Tony Avelar)

(9 of )A member of the Buffalo Bills wears a pink ribbon for breast cancer awareness before an NFL football game against the San Francisco 49ers in San Francisco, Sunday, Oct. 7, 2012. (AP Photo/Tony Avelar)

(10 of )Buffalo Bills wide receiver T.J. Graham (11) runs against San Francisco 49ers safety Donte Whitner (31) during the second half of an NFL football game in San Francisco, Sunday, Oct. 7, 2012. (AP Photo/Tony Avelar)

(11 of )Buffalo Bills quarterback Ryan Fitzpatrick (14) against the San Francisco 49ers during the second half of an NFL football game in San Francisco, Sunday, Oct. 7, 2012. (AP Photo/Tony Avelar)

(12 of )Buffalo Bills wide receiver Brad Smith (16) runs against San Francisco 49ers linebacker Patrick Willis (52) during the second half of an NFL football game in San Francisco, Sunday, Oct. 7, 2012. (AP Photo/Tony Avelar)

(13 of )Buffalo Bills wide receiver Brad Smith (16) runs against San Francisco 49ers linebacker Patrick Willis (52) during the second half of an NFL football game in San Francisco, Sunday, Oct. 7, 2012. (AP Photo/Tony Avelar)

(14 of )A San Francisco 49ers player wears pink shoes for breast cancer awareness before an NFL football game against the Buffalo Bills in San Francisco, Sunday, Oct. 7, 2012. (AP Photo/Tony Avelar)

(15 of )San Francisco 49ers quarterback Alex Smith (11) before an NFL football game against the Buffalo Bills in San Francisco, Sunday, Oct. 7, 2012. (AP Photo/Tony Avelar)

(16 of )The San Francisco 49ers are introduced before an NFL football game against the Buffalo Bills in San Francisco, Sunday, Oct. 7, 2012. (AP Photo/Tony Avelar)

(17 of )San Francisco 49ers quarterback Alex Smith (11) against the Buffalo Bills during the first half of an NFL football game in San Francisco, Sunday, Oct. 7, 2012. (AP Photo/Tony Avelar)

(18 of )San Francisco 49ers quarterback Alex Smith (11) against the Buffalo Bills during the first half of an NFL football game in San Francisco, Sunday, Oct. 7, 2012. (AP Photo/Tony Avelar)

(19 of )San Francisco 49ers quarterback Alex Smith (11) against the Buffalo Bills during the first half of an NFL football game in San Francisco, Sunday, Oct. 7, 2012. (AP Photo/Tony Avelar)

(20 of )Buffalo Bills kicker Rian Lindell (9) drinks from a bottle of Gatorade before an NFL football game against the San Francisco 49ers in San Francisco, Sunday, Oct. 7, 2012. (AP Photo/Ben Margot)