Group Leader

Research Overview

The Rogerson laboratory studies the pathogenesis and immunity of malaria infection in the human host. We use in vitro models and clinical samples from individuals in malaria-affected countries , most notably Malawi and Papua New Guinea, in our studies. More recently we have begun collaborations on the development of new diagnostics for malaria.

Our laboratory has performed world-leading research on how malaria in the mother affects the development and function of the human placenta, and the growth and development of her baby. We also work on severe malaria- understanding why some children develop life threatening infections, while others with similar exposure either remain well or develop mild illness.

We have a strong interest in the early, innate cellular immune response to malaria infection. Current studies examine the roles of white blood cells including monocytes and gamma delta T cells, in both laboratory and clinical studies. We study how both adipose tissue responses, and placental sugars, may modify the immune response to malaria. A developing area of interest is novel approaches to identifying antibody responses that protect pregnant women and young children from malaria.

Funding

National Health and Medical Research Council of Australia: Program Grant (Cowman, Crabb, Beeeson, Mueller, Rogerson): 'Understanding malaria in the human host' NHMRC: Project Grants to S Rogerson and A Jaworowski , and to L Randall and J Said Bill & Melinda Gates Foundation Grand Challenges Explorations 'Development of an Ultra-Sensitive Non-Invasive Point-of-Care Immunosensor for Malaria Elimination in the Asia Pacific Region' Thrasher Foundation 'Intermittent treatment in pregnancy with azithromycin - does it work by ablating inflammation?' The University of Melbourne

Research Opportunities

This research project is available to PhD students to join as part of their thesis.Please contact the Research Group Leader to discuss your options.