There has been another sighting of missing 44-year-old Karen Scott, gardai have said.

The Finglas woman, who has Down Syndrome, has been missing since Friday.

Gardai said this evening that Ms Scott was at a licensed premises located on Burgh Quay, Dublin 2 on Friday.

She was seen on CCTV leaving the premises at around 9.40pm.

Missing Dublin woman Karen Scott.

"She turned left on exiting the premises and can be seen turn left onto D'Olier St. She was wearing the same clothes as originally reported and she was in possession of her suitcase." a garda spokesperson said.

Karen (44) was last seen when she left her home in Finglas at around 3.30pm on Friday last.

She is 5'4'' tall, of medium build, with blue eyes and short blonde hair.

A search party of friends and neighbours with Missing flyers for Karen Scott, missing since Friday 24th June, outside Karen's house on Barnamore Grove, Finglas, Dublin. Picture: Caroline Quinn

When last seen she was wearing white runners, a peach coloured hoodie top, and black jeans.

"Karen had a small red suitcase containing items of clothing so she could have changed her clothes.

"The clothes she had included bright tops, yellow and green, a mini-skirt and shorts'" he said.

She was last seen on Berkeley Road in Phibsboro.

Gardai are following 'a number of lines of inquiry' including a number of possible sightings. One of the sightings reported was in Penneys in Cork City and gardai were investigating that possibility, he said.

Karen had never travelled outside Dublin, he said.

She did not use a travel pass on local buses as she was a 'well-known' figure.

"The furthest she travelled was to the city centre," he said.

A Civil Defence has also joined in the search, he added.

The Finglas woman has been four days now and her family are increasingly fearful for her.

"She has no money or bus pass, so we can't see how she could have travelled anywhere," said one neighbour this morning.

"Another search party will go into the city this morning. There are so many flats and bedsits in the city she could be anywhere," she added.

In the CCTV footage, Karen appears to be pulling a small suitcase with a handle and wheels behind her. Her mother, Kathleen, said her family were worried about her.

“Karen is very independent and knows her bus routes and everything and she has gone out before on her own but she has always come back that night. This time it is different,” Kathleen said.

“We are very concerned for her. There have been no sightings since Friday.

“I had been up in Finglas village with her doing some shopping earlier and when we got home she said she was going upstairs for a lie down. I dozed off on the couch myself for a while and when I woke up she was gone.”

A group of friends and neighbours are organising a leaflet drop in the area and searches are also taking place in the city centre near where Karen was last seen.

Anyone who has seen Karen or who can assist in locating her is asked to contact Finglas Garda Station on 01 6667500 or any garda station.