Democratic Senate hopeful Elizabeth Warren and rival Republican Sen. Scott Brown's campaign have both denounced the latest negative ad released by the Karl Rove backed Crossroads GPS political action committee, although Brown added a barb for the Harvard professor.

“Senator Brown has made it clear that he wishes third-party groups on both sides would keep their negative ads out of Massachusetts," said Jim Barnett, Brown's campaign manager. "Regrettably, Professor Warren has cheered on negative attack ads against Scott Brown, and refuses to join his call for outside groups to stop interfering.”

Warren said previously that she believes "a blanket notion that nobody talks except the two candidates is not within the spirit of how democratic elections work."

Brown, however, called for all outside groups to keep out of the Senate race in Massachusetts.

The latest ad released by Crossroads GPS, a conservative group backed by Republican strategist Rove, blames Warren for the big bonuses bank executives received from federal bailout money while average citizens were foreclosed upon, following the distribution of monies associated with the Troubled Asset Relief Program.

A previous ad by Crossroads GPS tied Warren to the Occupy Wall Street movement and described her as siding with "extreme-left protests."

"I expected Wall St. to throw everything they had at me in this race; I helped found the Consumer Financial Protection Bureau to curb their abuses, after all," Warren said on her Facebook page. "But I never did imagine they'd fund an ad attacking me as being their own ally."

“We must be doing something right if Karl Rove is attacking us. And boy is he ever - with ridiculous attack ads financed by Wall Street,” Warren said in the video. “Let’s be clear, Karl Rove isn’t just attacking me. He and his buddies are attacking all of us in Massachusetts who want a level playing field for middle class families.”