Pitigliano is known for its Etruscan cave-tombs and fine wine. Noted tourist sites include the 16th century aqueduct and the narrow streets of the old Jewish ghetto. Jews settled in Pitigliano in the 15th century. The synagogue dates from 1598.

Via Unità d'Italia Cemetery: +39.0564614230: The old Jewish cemetery is located at the base of the rock on the outskirts of the town, on the road to Marciano. The cemetery part carved in the tufa stone has been recently restored.

The cemetery used for the first time in the 16th century, when David de’ Pomis, a doctor, buried his wife. [January 2009]