Surface properties of biomaterials play a major role in the governing of cell
functionalities. It is well known that mechanical, chemical and nanotopo-
graphic cues, for example, influence cell proliferation and ...

Fabrication of new biodegradable scaffolds that guide and stimulate tissue regeneration is still a major issue in tissue engineering approaches. Scaffolds that possess adequate biodegradability, pore size, interconnectivity, ...

Radial glia cells (RGC) are multipotent progenitors that generate neurons and glia during CNS development,
and which also served as substrate for neuronal migration. After a lesion, reactive glia are the
main contributor ...

Lately there has been an increasing interest in
the development of tools that enable the high throughput
analysis of combinations of surface-immobilized signaling
factors and which examine their effect on stem cell ...

When the intervertebral disc is removed to
relieve chronic pain, subsequent segment stabilization
should restore the functional mechanics of the native disc.
Because of partially constrained motions and the lack ...

Major limitations of calcium phosphate cements (CPCs) are their relatively slow degradation rate and the lack of macropores allowing the ingrowth of bone tissue. The development of self-setting cement foams has been proposed ...

It is about 20 years that tubular nerve guides have been introduced into clinical practice as a reliable alternative to autograft, in gaps notlonger-than 20 mm, bringing the advantage of avoiding donor site sacrifice and ...

In bone tissue engineering, the composition of the ionic extracellular environment (IEE) can determine
both cellular fate and a biomaterial
’
s development and performance. Therefore, precise control of the
IEE and a ...

The present study reports a novel approach for the
design and fabrication of polylactic acid (PLA) microparticle-
based scaffolds with microstructural properties suitable for
bone and cartilage regeneration. Macroporous ...

Regenerative medicine is an emerging multidisciplinary field that aims to restore, maintain or enhance tissues and hence organ functions. Regeneration of tissues can be achieved by the combination of living cells, which ...

Regenerative medicine strategies to promote recovery following traumatic brain injuries are currently focused on the use of biomaterials as delivery systems for cells or bioactive molecules. This study shows that cell-free ...

Despite their known osteoconductivity, clinical use of calcium phosphate cements is limited both by their relatively slow rate of resorption and by rheological properties incompatible with injectability. Bone in-growth and ...