Sreenath is the director of the Complex Systems Biology Center and also the Director of Case Systems Biology Initiative (Case SBI). In addition, he co-directs the UNESCO Global Issues Education Network Initiative (GENIe). He is a recipient of NIH-National Cancer Institute (NCI) Research Career Award in 2004.

His research interests are in systems biology with application of complex systems representation, multi-scale modeling, coordination and goal seeking to understand: (a) signal transduction in cancer and inflammation (MAPK and JAK/STAT pathways), and (b) biological causes and intervention approaches to hydrocephalus (cerebrospinal fluid accumulation). Sreenath conducts research with the Case Comprehensive Cancer Center and the School of Medicine (Neurosurgery). He also is involved with global systems modeling and analysis research (water, energy and policy targets).