CBS Sports' Randy Cross told the guys at Fantasy Football Live that he believed Charles could be lost for the season, and now a report from ESPN's Adam Schefter confirms that Charles is likely done for the year after tearing his ACL.

Charles was carted off in the first quarter after taking an awkward step while running out of bounds and eventually had the Lions mascot land on him. He was listed as questionable but never returned to the game, and now it appears he won't return this season.

It's a(nother) tremendous blow to a Chiefs team that couldn't possibly have gotten off on a worse foot in terms of trying to defend their AFC West title -- they've now been blown out by both the Bills and the Lions in the first two weeks of the season while managing to lose three of the best players (Charles, Eric Berry, Tony Moeaki) for the season.

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Charles lost control going out of bounds, took a bad step and wobbled on his leg before landing on the Lions mascot.

The Chiefs announced that his return is questionable.

Also questionable? The Chiefs chances of succeeding in what already appears to be a snakebitten season. They've lost tight end Tony Moeaki and safety Eric Berry for the season, and if the Charles injury is serious, an offense that hasn't really been able to get rolling is going to struggle even further.

It's probably also worth noting that the Chiefs did their best to hand the Lions an early score on Sunday with some penalties, and even though they picked Matthew Stafford early, they gave the ball back on a fumble in that same play. It's quite the cluster for Todd Haley's squad.

The potential for a serious injury to Charles is the most devastating blow yet, though. Despite the frustrating lack of carries, he's what makes the KC offense go, and without him, it's quite possible that KC could be stuck in reverse all season.

On the heels of Jamaal Charles' 177-yard rushing effort against the Bills two weeks ago, his performance (53 yards on 10 carries) against the Raiders was pretty disappointing. But, hey, it's the Raiders, whatcha gonna do, right?

Or maybe it wasn't Oakland's defensive play, and instead it's the old mystery injury that keeps fantasy owners awake at night.

According to our Chiefs Rapid Reporter Bob Gretz, Todd Haley admitted that Charles had to leave the game against Oakland because of "physical problems he would not describe."

As if, you know, people needed another reason to love Todd Haley.

If Charles was coming in and out because of the injury, it seems like it's something that's not too major (good news), but might also be something that's nagging (terrible news).

Expect Haley to get continually grilled for the rest of the week about the nature of Charles' injury -- at some point he'll have to attach some sort of label to it, unless he thinks he can sneak "Questionable: Body" by the NFL.

The good news for Kansas City is that even though they could theoretically lose their home run hitter for a game, they face Denver next, and Thomas Jones should be able to do plenty of damage against their defense.