Clooney also talks about more serious issues, namely his recent and upcoming flicks. Of "The Ides of March," he says it was "not designed for everybody to see, but I don't give a shit … I don’t need to be more famous, and we shot it for $12 million, so anything we do is nice."

Of "The Descendants," which has already stirred Oscar buzz — for Clooney's performance and the movie itself — the actor/writer/director says he'll be "shocked" if it doesn't earn a Best Picture nomination. "It's that good," he says.

Clooney also talks to the magazine about current girlfriend Stacy Keibler and her tweeting habit ("She can do whatever she wants. I rarely tell anybody what they should be doing with their life"), and in a rare bit of TMI, discusses losing his virginity at age 16 but experiencing his first orgasm much earlier.

"I believe it was while climbing a rope when I was six or seven years old," he says. "I mean, nothing came out, but all the other elements were there. I remember getting to the top of the rope, hanging off the rope, and going, 'Oh, my God, this feels great!'"

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