Associated products

Specifications

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Applications

Functional Studies

SDS-PAGE

Endotoxin level

< 0.100 Eu/µg

Form

Lyophilised

Additional notes

The ED50, determined by the dose-dependent stimulation of murine D10S cells, is < 0.005 ng/ml, corresponding to a specific activity of > 2 x 108 units/mg.

Concentration information loading...

Preparation and Storage

Stability and Storage

Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

n/a

This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

Alternative names

BAF

FAF

Hematopoietin 1

Hematopoietin-1

IL 1 alpha

IL 1A

IL-1 alpha

Il-1a

IL1

IL1 ALPHA

IL1A

IL1A_HUMAN

IL1F1

Interleukin 1 alpha

Interleukin-1 alpha

Interleukin1 alpha

LAF

LEM

Preinterleukin 1 alpha

Pro interleukin 1 alpha

see all

Function

Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.

Sequence similarities

Belongs to the IL-1 family.

Domain

The similarity among the IL-1 precursors suggests that the amino ends of these proteins serve some as yet undefined function.

Cellular localization

Secreted. The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins.