LV-426, is one of three known moons orbiting Calpamos in the Zeta Reticuli system, 39 light years away from Earth. The LV-426 Hotshots are the tough as nails terraforming team that lead the colonization efforts for mega corporation, Weyland-Yutani, in the mid-22nd century. The colony took on the name of Hadley's Hope, after found Curtis Hadley, and housed approximately 158 people before a minor pest control problem lead to the colony's demise.

"We're in the pipe, 5 by 5." With those iconic words, representatives of the Weyland-Yutani Corp. backed by a group of Colonial Marines descended onto the surface of LV-426 to try and ascertain what had happened to the terraforming colonists of the Hadley's Hope settlement. Spoiler alert, it didn't end well...