Biotin is a water-soluble B-vitamin (vitamin B7), formerly known as
vitamin H or coenzyme R.

It is composed of a ureido (tetrahydroimidizalone) ring fused with
a tetrahydrothiophene ring. A valeric acid substituent is attached
to one of the carbon atoms of the tetrahydrothiophene ring. Biotin
is a coenzyme for carboxylase enzymes, involved in the synthesis of
fatty acids, isoleucine, and valine, and in gluconeogenesis.

Biotin deficiency can be caused by inadequate dietary intake or
inheritance of one or more inborn genetic disorders that affect
biotin metabolism (see multiple carboxylase deficiency).
Subclinical deficiency can cause mild symptoms, whereas the inborn
genetic disorders can have severe (even lethal) consequences.
Neonatal screening for biotinidase deficiency began in the United
States in 1984 and today many countries test for this disorder at
birth. Individuals born prior to 1984 are unlikely to have been
screened, thus the true prevalence of the disorder is unknown.

Biotin-thiamine-responsive basal ganglia disease is another
potentially life-threatening condition that requires biotin (and
thiamine, another B vitamin) for treatment. Claims are made that
biotin supplements support hair and nail growth, and so the vitamin
is marketed for these indications. The nails data is from three
trials without placebo controls, conducted with 2,500
micrograms/day. After six months, nails were thicker and less
brittle in about 2/3 of the subjects (Hochman 1993, Colombo 1990,
Floersheim 1989).

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