It's important to know about safety warnings associated with analgesics so that undesirable side effects can be minimized. Here are 10 important things you should know about using analgesics.

1 - Analgesics are a class of drugs used to relieve pain. They are also referred to as painkillers.

For pain relief to occur by taking an analgesic medication, pain signals going to the brain are blocked or interpretation of the signals by the brain is interrupted.

2 - There are two categories of analgesics: non-narcotics and narcotics.

Acetaminophen/Paracetamol is the most widely used non-narcotic analgesic. It is sold over-the-counter as Panadol, Panamax Tylenol or acetaminophen. It also can be an ingredient in narcotic analgesics.

3 - Acetaminophen/Paracetamol is most effective for mild to moderate pain. It is extremely important to follow the prescribing instructions.

The daily maximum dose of acetaminophen is 4000 mg. Taking more than the maximum allowable dose or taking it for long duration can increase the risk of liver damage. Alcohol consumption when using acetaminophen also increases the risk of liver damage or may have fatal consequences. The oral dose of acetaminophen for a child is based on age, with the allowable range from 40-650 mg every 4 hours.

4 - Patients must be aware of the cumulative effect of acetaminophen since it is found in so many products, including cold, sinus, cough, and allergy medications.

The cumulative daily total for acetaminophen should not exceed 4000 mg, even if the acetaminophen is coming from various sources. This is a significant warning and cannot be emphasized enough.

5 - There are two categories of narcotic analgesics - opiates and opioids.

Opiates are the alkaloids found in opium. Opioids are derivatives of opiates.

6 - Opioids bind to opioid receptors in the central nervous system and gastrointestinal tract.

There are four categories of opioids: endogenous opioids (produced in the body), opium alkaloids, semi-synthetic opioids, fully synthetic opioids. Endorphins are an example of an endogenous opioids. Morphine is an opium alkaloid. Semi-synthetic examples include,oxycodone, hydrocodone, hydromorphone. Fully synthethic includes propoxyphene, tramadol,pentazocine, Demerol.

For patients with severe, intractable pain, there is not an upper limit for dose of opioids but the dose MUST be increased gradually to avert serious side effects like respiratory distress.

8 - There are common side effects associated with opioids.

Nausea, vomiting, drowsiness, constipation, dry mouth, urinary retention, and orthostatic hypotension are among the common side effects.

9 - There are less common side effects associated with opioids.

Confusion, hallucinations, itching, hives, slow or rapid heart rate, flushing, raised intracranial pressure, and muscle rigidity are among the less common side effects.

10 - Severe side effects and adverse reactions are possible with opioids.

Respiratory depression and fatal overdose are possible with opioid use. It is critical that exact directions be followed when using these drugs.

CONDITIONS OF USE: This information is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. Your GP should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.