Re:
Notice of disclosure
filed in Exchange Act Annual Report under Section 219 of the Iran Threat Reduction and Syria Human Rights Act of 2012 and Section
13(r) of the Securities Exchange Act of 1934, as amended

Dear Sirs:

Pursuant to Section 219 of the Iran Threat Reduction
and Syria Human Rights Act of 2012 and Section 13(r) of the Securities Exchange Act of 1934, as amended, notice is hereby provided
that EDAP TMS SA has made disclosure pursuant to those provisions in its Annual Report on Form 20-F for the year ended December
31, 2016, which was filed with the Securities and Exchange Commission on April 3, 2017.