I was on a regimen of pills and supplements to drop my cholesterol for many months. I didn't want to take statins. There was little improvement from those supplements so I added only Pantethine (900mg daily) to my regimen for the next 4 months while at the same time dropping 20+lbs. When I took my next blood test, my numbers didn't improve at all. I'm serious about taking supplements and not taking statins, so I really fell for all the talk of Pantethine and it's benefits, but despite me never cheating on my choice of healthy foods, I was seriously surprised that this supplement did nothing for me at all.