7
Depending if a molecule is ionized or not determines if it can pass through a cell membrane C E L L M E M B R A N E Ionized Molecule Non-Ionized Molecule

8
Need three things to figure out whether drug is MAJORITY in lipophilic or hydrophilic form 1.Whether the drug is an acid drug or a base drug. 2.The pKa of the drug (pH at which number of ionized = number of nonionized molecules)‏ 3.pH into which the drug is going to be placed

12
WHEN GIVEN: 1.Acid / Base nature of the drug 2.Drug’s pKa 3.Environmental pH drug is put into ionizednon-ionized Be able to predict whether majority of drug is in the ionized form or non-ionized form hydrophiliclipophilic Be able to state whether majority of drug is in the hydrophilic form or lipophilic form Be able to predict whether it can be absorbed across membrane (PO) or dissolved in water (SQ, IM)‏

18
WHEN GIVEN: 1.Acid / Base nature of the drug 2.Drug’s pKa 3.Environmental pH drug is put into ionizednon-ionized Be able to predict whether majority of drug is in the ionized form or non-ionized form hydrophiliclipophilic Be able to state whether majority of drug is in the hydrophilic form or lipophilic form Be able to predict whether it can be absorbed across membrane (PO) or dissolved in water (SQ, IM)‏