BioPAX pathway converted from "isovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2" in the Reactome database.LEFT-TO-RIGHT1.3.8.4isovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>ISV-CoA3-methylbutanoyl-CoAisovaleryl-CoAReactome DB_ID: 70715mitochondrial matrixGENE ONTOLOGYGO:0005759isovaleryl-CoA [ChEBI:15487]isovaleryl-CoAChEBICHEBI:15487Reactome Database ID Release 7270715Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=70715ReactomeR-ALL-707153Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-70715.3Reactomehttp://www.reactome.orgFADFlavin adenine dinucleotideReactome DB_ID: 113596FAD [ChEBI:16238]FADFlavin adenine dinucleotideChEBICHEBI:16238Reactome Database ID Release 72113596Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113596ReactomeR-ALL-1135962Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-113596.2bMC-CoAbeta-methylcrotonyl-CoA3-methylbut-2-enoyl-CoAReactome DB_ID: 707443-methylbut-2-enoyl-CoA [ChEBI:15486]3-methylbut-2-enoyl-CoAChEBICHEBI:15486Reactome Database ID Release 7270744Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=70744ReactomeR-ALL-707443Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-70744.3FADH2Reactome DB_ID: 31649FADH2 [ChEBI:17877]FADH2ChEBICHEBI:17877Reactome Database ID Release 7231649Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=31649ReactomeR-ALL-316492Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-31649.2ACTIVATIONIVD tetramerReactome DB_ID: 97926814IvdIVDP12007Reactome DB_ID: 9792679UniProt:P12007IvdRattus norvegicusNCBI Taxonomy10116UniProtP1200730EQUAL423EQUALReactome Database ID Release 729792679Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9792679ReactomeR-RNO-707291Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-RNO-70729.14Reactome Database ID Release 729792681Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9792681ReactomeR-RNO-707301Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-RNO-70730.1GENE ONTOLOGYGO:0008470gene ontology term for cellular functionMIMI:0355Same Catalyst ActivityReactome Database ID Release 729792682Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9792682Reactome Database ID Release 729792684Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9792684ReactomeR-RNO-707451Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-RNO-70745.1Mitochondrial isovaleryl dehydrogenase (IVD) catalyzes the reaction of isovaleryl-CoA and FAD to form beta-methylcrotonyl-CoA and FADH2 (Finocchiaro et al. 1978; Rhead and Tanaka 1980). Crystallographic studies demonstrated the existene of a tetramer of IVD polypeptides lacking an aminoterminal mitochondrial targeting sequence (Tiffany et al. 1997).3597357Pubmed1987Purification and properties of short chain acyl-CoA, medium chain acyl-CoA, and isovaleryl-CoA dehydrogenases from human liver.Finocchiaro, GIto, MTanaka, KJ Biol Chem 262:7982-99214289Pubmed1997Structure of human isovaleryl-CoA dehydrogenase at 2.6 A resolution: structural basis for substrate specificity,.Tiffany, KARoberts, DLWang, MPaschke, RMohsen, AWVockley, JKim, Jung-Ja PBiochemistry 36:8455-646928646Pubmed1980Demonstration of a specific mitochondrial isovaleryl-CoA dehydrogenase deficiency in fibroblasts from patients with isovaleric acidemia.Rhead, WJTanaka, KProc Natl Acad Sci U S A 77:580-3inferred from electronic annotationEVIDENCE CODEECO:0000203