This course focuses on the process of integrating research and practice in the health care setting for advanced practice nurses. Critical analysis and synthesis of scientific knowledge related to clinical problems are explored through appraisal of organizational culture and dynamics, models and immersion into the clinical phenomena of interest. Emphasis will be placed on how problems and questions are articulated and grounded in the clinical phenomena, supported and synthesized through the literature and transformed to develop clinically culturally relevant and usable knowledge for advanced practice nurses.