Prior exposure to salient win-paired cues in a rat gambling task increases sensitivity to cocaine self-administration and suppresses dopamine efflux in nucleus accumbens: support for the reward deficiency hypothesis of addiction

Disclosures

The authors declare no competing financial interests.

We gratefully acknowledge Sukhbir Kaur for genotyping animals used in experiment two. We also thank Mason Silveira for assisting with breeding animals used in this work, and Giada Vacca for assistance with HPLC. This work was supported by an open operating grant awarded to CAW from the Canadian Institutes for Health Research (CIHR). In the last 3 years, CAW has been retained as an expert witness by Hogan Lovells LLP, and received due compensation. AGP declares a patent related to glutamate receptor function (A Peptide that Specifically Blocks Regulated AMPA Receptor Endocytosis and Hippocampal CA1 Long-term Depression; European 04789721.0, and United States 13/066,700). AGP also declares a pending patent for the use of d-Govadine in treatment of cognitive deficits. The authors confirm they have no other conflicts of interest or financial disclosures to make.

Prior exposure to salient win-paired cues in a rat gambling task increases sensitivity to cocaine self-administration and suppresses dopamine efflux in nucleus accumbens: support for the reward deficiency hypothesis of addiction

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Prior exposure to salient win-paired cues in a rat gambling task increases sensitivity to cocaine self-administration and suppresses dopamine efflux in nucleus accumbens: support for the reward deficiency hypothesis of addiction