For the Consumer

In addition to its needed effects, some unwanted effects may be caused by amoxicillin (the active ingredient contained in DisperMox). In the event that any of these side effects do occur, they may require medical attention.

You should check with your doctor immediately if any of these side effects occur when taking amoxicillin:

Incidence not known

Abdominal or stomach cramps or tenderness

back, leg, or stomach pains

black, tarry stools

bleeding gums

blistering, peeling, or loosening of the skin

bloating

blood in the urine

bloody nose

chest pain

chills

clay-colored stools

cough

dark urine

diarrhea

diarrhea, watery and severe, which may also be bloody

difficulty with breathing

difficulty with swallowing

dizziness

fast heartbeat

feeling of discomfort

fever

general body swelling

headache

heavier menstrual periods

hives or welts

increased thirst

inflammation of the joints

itching

joint or muscle pain

loss of appetite

muscle aches

nausea or vomiting

nosebleeds

pain

pain in the lower back

pain or burning while urinating

painful or difficult urination

pale skin

pinpoint red spots on the skin

puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue

rash

red, irritated eyes

redness, soreness, or itching skin

shortness of breath

sore throat

sores, ulcers, or white spots in the mouth or on the lips

sores, welting, or blisters

sudden decrease in the amount of urine

swollen, lymph glands

tenderness

tightness in the chest

unpleasant breath odor

unusual bleeding or bruising

unusual tiredness or weakness

unusual weight loss

vomiting of blood

watery or bloody diarrhea

wheezing

yellow eyes or skin

Some of the side effects that can occur with amoxicillin may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

Dermatologic

Dermatologic side effects have included rash, fixed drug eruption, and bullous pemphigoid. Erythematous maculopapular rashes occur frequently in patients with infectious mononucleosis who take amoxicillin (the active ingredient contained in DisperMox) these may be due to hypersensitivity.[Ref]

Three out of four patients with infectious mononucleosis and an amoxicillin-associated rash displayed hypersensitivity to amoxicillin and ampicillin by skin tests and lymphocyte transformation tests. Two of these patients had side-chain-specific sensitization.[Ref]

Amoxicillin has been associated with hemorrhagic, sometimes inflammatory colitis, which typically affects the ascending colon. Clostridium difficile pseudomembranous colitis has been reported.[Ref]

Renal

Renal side effects have included crystalluria and acute interstitial nephritis, often associated with fever, rash and eosinophilia.[Ref]

Hematologic

A patient undergoing dental extraction and receiving warfarin anticoagulation therapy had prolonged bleeding times (PT and INR), and decreased hemoglobin and hematocrit. The bleeding was felt due to vitamin K deficiency as a result of depletion of intrinsic vitamin K-producing gut flora from use of amoxicillin (the active ingredient contained in DisperMox) for prophylaxis of subacute bacterial endocarditis.[Ref]

Hematologic side effects associated with penicillins have included thrombocytopenia, anemia, leukopenia, thrombocytopenic purpura, agranulocytosis, hemolytic anemia, eosinophilia, and granulocytopenia. These effects are usually reversible and are believed to be due to hypersensitivity reactions.[Ref]

Immunologic

Immunologic side effects have included mucocutaneous candidiasis and vulvovaginal mycotic infection.

Nervous system

Nervous system side effects have rarely included headache, somnolence, dizziness, reversible hyperactivity, agitation, anxiety, insomnia, confusion, convulsions, behavioral changes, and aseptic meningitis. Rare cases of psychosis associated with amoxicillin (the active ingredient contained in DisperMox) therapy have been reported but may have been due to underlying infection or concomitant medication.[Ref]

Hepatic

Other

Other side effects have rarely included brown, yellow, or gray tooth discoloration, primarily in pediatric patients. Brushing or dental cleaning reduced or eliminated the discoloration in most cases.[Ref]

Professional resources

Related treatment guides

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