anti-Baculoviral IAP Repeat-Containing 6 (BIRC6) Antibodies

BIRC6 encodes a protein with a BIR (baculoviral inhibition of apoptosis protein repeat) domain and a UBCc (ubiquitin-conjugating enzyme E2, catalytic) domain. Additionally we are shipping BIRC6 Kits (9) and and many more products for this protein.

More Antibodies against BIRC6 Interaction Partners

Since specific expression of BRUCE protein was revealed in majority of gastric carcinoma tissues, BRUCE protein may be a useful therapeutic target for cancer therapy.

BIRC6 targeting inhibited the growth of enzalutamide-resistant castration-resistant prostate cancer models and may represent a new option for clinical treatment of advanced, enzalutamide-resistant prostate cancer

Apollon expression is associated with the biological characteristics of esophageal squamous cell carcinoma (ESCC), and may be a valuable prognostic factor and a novel chemotherapeutic target for ESCC treatment.

Apollon role in the multidrug resistance of human chronic myelogenous leukemia cells

Apollon gene silencing can induce apoptosis and growth impairment in HeLa cells. In this regard, apollon can be considered a candidate therapeutic target in HeLa cells as a positive human papillomavirus cancer cell line.

Results show that in addition to the scaffolding function in complex formation, BRUCE has an E3 ligase function to promote BRIT1 (show MCPH1 Antibodies) deubiquitination by USP8 (show USP8 Antibodies) leading to accumulation of BRIT1 (show MCPH1 Antibodies) at DNA double-strand break.

BIRC6 overexpression is a predictor of poor prognosis in colorectal cancer and could be a potential target for colorectal cancer therapy.

The study demonstrates that the T allele of the rs2754511 in the BIRC6 gene plays a protective role in pseudoexfoliative glaucoma patients of the Pakistani population.

These results establish a previously unrecognized link between NFAT (show NFATC1 Antibodies) signaling and regulation of IAP (show ALPI Antibodies) expression and are the first to identify a signaling pathway that increases BRUCE expression.

BIRC6 Antigen Profile

Protein Summary

This gene encodes a protein with a BIR (baculoviral inhibition of apoptosis protein repeat) domain and a UBCc (ubiquitin-conjugating enzyme E2, catalytic) domain. This protein inhibits apoptosis by facilitating the degradation of apoptotic proteins by ubiquitination.