In biological systems, DNA/RNA-protein interactions as well as drug-DNA interactions play important roles in genetic processes. A fundamental understanding of these processes requires a detailed structural knowledge of ...

Studies were done to determine the ability of the rabbit cortical collecting tubule, studied in vitro, to acidify its luminal fluid. The antimony electrode was adapted to allow the continuous measurement of the pH of ...

The actin cytoskeleton is a critical part of intracellular structure, responsible for the general shape and integrity of all cells. New insights into the dynamic nature of the cytoskeleton describe additional roles for ...

In order to investigate the action of ovarian steroids upon the hypothalamic LHRH pulse generator in the female rat, I have examined the in vivo activity of the hypothalamic LHRH pulse generator in the different endocrine ...

We have analyzed the behavior of a linear, cyclic, four state model of regulation of contraction of smooth muscle. The model involves twenty one parameters: sixteen rate constants, three initial conditions, and NT$\sb3$ ...

This study examines the structure of the active center of bacterial luciferase by exploiting the existence of two well-documented structural features of the (alpha) subunit of the enzyme, the essential cysteine and the ...

Bacterial luciferase catalyzes the mixed-function oxidation of a long-chain saturated aldehyde and FMNH(,2) to yield the carboxylic acid, FMN and blue-green light. The enzyme is inactivated by 2,4-dinitrofluorobenzene ...

Cytochrome P-450$\sb{\rm cam}$, from Pseudomonas putida, catalyzes the regio- and stereospecific hydroxylation of the monoterpene d-camphor to afford 5-exo-hydroxycamphor as the sole product. The roles of specific active ...

Brown stem rot (BSR) is a fungal disease of soybean {Glycine max (L.) Merr.} caused by Phialophora gregata Allington and Chamberlain (W. Gams). Field and greenhouse tests were performed to study the effect of BSR resistance ...

The progression of breast tumors to steroid-autonomous and antiestrogen-resistant phenotypes confounds our ability to treat breast cancer with antiestrogens, the most efficacious hormone treatment used clinically. We ...