Natiya Mason is the wife of Dr.Mason, and the mother of Fredrick and Edgar Mason. She served as a major antagonist as the "Black Plague Queen", but has been returned to normal by the efforts of Zack Xargus.

When Natiya got infected by the Black Plague Virus, she instantly transformed into a monster. She has pitched black eyes. Green jaggered teeth. Pale white skin with green veins appearing. Several spikes-like horns on her head. And several spider-like arms sticking out of her back. She had the following abilities: