Baby Animal appeared in the ending tag of each Muppet Babies episode, which included such appearances as breaking out of an egg or hanging on behind an airplane. These antics always involved Baby Gonzo being hurt or humiliated in some way, and, on a few occasions, others as well. His trademark line was "Go bye-bye!" He also had a distinctive laugh, which made the phrase as "Go bye-bye! Yaabababababababa!"

When voiced by Howie Mandel, Animal had thick eyelashes all around his eyes and his face would sometimes turn orange as a result of an ink-and-paint glitch. When Dave Coulier took over, Animal's design and animation became much more refined; his face was always pink and the eyelashes were only on the tips of his eyelids.