Not in my opinion. Liquid smoke is just that, condensation from smoke. I saw a special on it one time, one of those How do they make that shows. The equipment reminded me of hi-tech stills, where the product was liquid smoke instead. It's really pretty pure, not a chemical substitute. Smoked paprika just doesn't have that strong smoke taste. It has another layer of flavor, but it's not strong hickory (for instance) like LS. You're not going to sprinkle some in water and smell like something is burning.