Significant numbers of female high school athletes and non-athletes suffer from one or more components of the female athlete triad, a combination of three conditions that can lead to cardiovascular disease, according to a new study by Medical College of Wisconsin researchers in Milwaukee.

The study results were presented today at the AmericanCollege of Sports Medicine at Indianapolis, by Anne Z. Hoch, DO, associate professor of orthopedic surgery and physical medicine and rehabilitation at the MedicalCollege and director of the Froedtert & Medical College Sports Medicine Program. She is also a member of the MedicalColleges CardiovascularCenter.

Dr. Hoch found that 78% of female high school athletes and 65% of female high school non-athletes display one or more components of the female athlete triad. The triad is a combination of three conditions low energy availability, menstrual abnormalities and low bone mineral density that often leads to the same steroid and hormonal profiles as post-menopausal women.

We are concerned that non-athletic girls have some of the same components of the female athlete triad as athletes and are, in fact, at greater risk for low bone density, says Dr. Hoch. These young women are under great pressure to conform to societys standards of body image. In an effort to lose weight, they are restricting their caloric intake and adapting unhealthy nutrition habits.

The study, conducted at FroedtertHospital, examined 80 varsity athletes and 80 non-athletes at an all-girls school in Milwaukee. Ninety-three percent of non-athletes were found to have calcium deficiencies, compared to 74% of athletes.

Most important and alarming is that 30% of the non-athletes versus 16% of athletes were found to have low bone mineral density putting them at greater risk for developing osteoporosis earlier in life, says Dr. Hoch.

Both groups showed little difference in low energy availability, with 39% of non-athletes and 36% of athletes reporting this condition.

The athletes reported 33% more menstrual abnormalities than the non-athletes. Women who have normal periods, and hence normal estrogen levels, are less likely to display changes in the function of the layer of cells that line the interior of blood vessels, called the endothelium.

Dr. Hoch began her studies in the late 1990s to see if young women who have menstrual abnormalities as a result of participating in intense sports are likely to develop cardiovascular disease similar to that seen in postmenopausal women. She and her colleagues were able to show that young women who had the triad also had early vascular change that is a precursor to cardiovascular disease.

We not only need to educate athletes about the consequences of the triad, now we must educate all students about the harmful effects of a restrictive diet in the adolescent period, says Dr. Hoch.

The study was funded in part by a grant from the GeneralClinicalResearchCenter, which has evolved into the Clinical and Translational Science Institute; the MedicalColleges CardiovascularCenter; and the Steve Cullen Run and Walk.