Neuronal ion transport and the spread of activity in neural networks are the two major themes in the lab. Neuronal ion transport underlies signaling at all fast synapses. The importance of neuronal ion transport was underscored by our recent discovery that reversed ion transport in the immature brain was blocking the effects of the anticonvulsants most commonly used to treat neonatal seizures, and that a safe and well-characterized diuretic could ameliorate this condition. Visit Dr. Staley's Pediatric Epilepsy Research Lab for more detail.