Sixty-four subjects (range 45-55?years) presenting with all five risk factors of metabolic syndrome were included, and Pycnogenol® was administered for 6?months. A group of 66 equivalent subjects were followed up as controls. In the 6-month study Pycnogenol® supplementation 150?mg/day decreased waist circumference, TG levels, blood pressure and increased the HDL cholesterol levels in subjects.