Abstract

Images having either the same or different modalities can be aligned using the systematic process of image registration. Inherent image characteristics including intensity non-uniformities in magnetic resonance images and large homogeneous non-vascular regions in retinal and other generic image types however, pose a significant challenge to their registration. This paper presents an adaptive expectation maximisation for principal component analysis with mutual information (aEMPCA-MI) similarity measure for image registration. It introduces a novel iterative process to adaptively select the most significant principal components using Kaiser rule and applies 4-pixel connectivity for feature extraction together with Wichard's bin size selection in calculating the MI. Both quantitative and qualitative results on a diverse range of image datasets, conclusively demonstrate the superior image registration performance of aEMPCA-MI compared with existing MI-based similarity measures.

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