Current Topics in Melanin Pigmentation and its Application to the Management and Pathophysiology of Pigmentary DiseasesKowichi Jimbow
Dermatol Sinica 14: 1-14, 1996
Mechanisms involved in the biosynthesis of melanin pigments and melanosomes, and their structural organization are not well understood. However, elucidation of the molecular events involved in these processes would be important in understanding the biology and pathophysiology of normal and abnormal melanin pigmentation in the skin. This elucidation would also provide the basis of developing the targeted depigmenting and melanocytotoxic agents of hyperpigmented skin and pigmentary tumors. It also ..................More

Treat Cutaneous Hyperpigmentation with Chemical PeelingChun-Min Wang, Heng-Leong Chan
Dermatol Sinica 14: 22-26, 1996
We treated twelve cases of cutaneous hyperpigmentation with chemical peeling. These cases included five cases of melasma, one case of solar lentigines, two cases of periorbital hyperpigmentation, two cases of freckles and two cases of postinflammatory hyperpigmentation. The reagents of treatments included 50% glycolic acid and 18% to 25% trichloroacetic acid. In the melasma group, three patients had excellent results (improvement>75%) two patients got good results (improvement>50%) , the patient ..................More

Case Report

Borderline Tuberculoid leprosy with Late Beversal ReactionPa-Fan Hsiao, Hsin-Yi Su, Hsiu-Chin Chen, Yu-Hung Wu
Dermatol Sinica 14: 27-31, 1996
We report a case of borderline tuberculoid leprosy with late onset of reversal reaction. A 44-year-old Taiwanese male had an annular anesthetic plaque on his right thigh and was diagnosed as leprosy in 1987. He received antileprosy therapy for one year and skin smear became negative. However, the lesion became erythematous and indurated in March 1994. The skin biopsy specimen revealed typical changes of reversal reaction which was consitent with the results of skin smear and lepromin test. He wa ..................More

Pseudomonas Septicemia with Ecthyma Gangrenosum and Nodular CellulitisFang-I Huang, Hsiu-Chin Chen, Hsin-Yi Su
Dermatol Sinica 14: 38-41, 1996
Pseudomonas aeruginosa is an important pathogen in immunocompromised patients. Septicemia can be rapidly fatal in infants and requires prompt diagnosis and aggressive treatment. We report a case of pseudomonas septicemia with typical ecthyma gangrenosum and uncommon nodular cellulitis, accompanied by hypogammaglobulinemia. It is recommended to incise and drain the persistent subcutaneous nodules in addition to systemic antibiotic therapy. Fulminant pseudomonas septicemia in previously healthy in ..................More

Syringocystadenoma Papilliferum and Unusual Basal Cell Neoplasm Arising in Naevus SebaceusWen-Wei Lin, Hao-Chiung Lin, Kit-Ching Wong
Dermatol Sinica 14: 42-46, 1996
Two small nodules with erosion developed in the plaque of nevus sebaceus in the 42 year-old male patient.Histopathological findings included two kinds of skin tumors except typical naevus sebaceus. One of the two neoplasms was consistent with syringocystadenoma papilliferum. The other was composed of numerous basaloid cell islands with areas differentiated toward hair follicles, sebaceous glands and apocrine glands. Unusual benign basal cell neoplasm was the impression. Few similar cases were no ..................More