The findings, published in Friday's (3/8) issue of the scientific journal Cell, provide the first detailed view of a flavivirus and offer structural information that can be used to unravel the processes that lead to viral infection. (eurekalert.org)

Dr. Bloom says that all flaviviruses have a similar genomic structure, and many scientists thought they would use the same survival mechanism and respond to the same vaccines and therapies, but the RML work shows otherwise. (rxpgnews.com)

Since immune cross reactivity has been reported within the Dengue virus serogroup, we hypothesized that T cells specific for this A*0201 restricted WNV stretch of envelope would cross-recognize different flaviviruses due to epitope conservation. (jimmunol.org)

Flaviviruses, such as Dengue virus (DENV) [ 2 ] and Yellow fever virus (YFV) [ 3 ], have been a common cause of devastating diseases in tropical and less developed countries, but in recent years the emergence of flaviviral zoonoses was observed worldwide. (hindawi.com)

Limited sequence identity with various isolates of hepatitis C virus and the relative positions of putative RNA helicases and RNA-dependent RNA polymerases in the predicted protein products of these molecules suggested that the GB agent contains two unique flavivirus-like genomes. (pnas.org)

The study released this week online in the Journal of Virology describes how a single virus protein--NS5--from the tick-borne Langat flavivirus counteracts the natural ability of interferon to combat the virus. (rxpgnews.com)

The discovery may help scientists develop antiviral compounds and other strategies to target dengue and other diseases caused by flaviviruses, says Richard Kuhn, associate professor of biological sciences and lead author of the study. (eurekalert.org)

This innovative multiplex immunoassay is a powerful alternative to ELISAs and VNTs for veterinary diagnosis of flavivirus-related diseases. (hindawi.com)

The unusual model involves culturing organs taken from Ixodes scapularis ticks and then infecting those organ cultures with flaviviruses, according to researchers at Rocky Mountain Laboratories, part of NIH's National Institute of Allergy and Infectious Diseases (NIAID). (nih.gov)

The NIAID scientists developed their model by dissecting three tick organs-the midgut, salivary glands and nervous tissue-and then culturing flaviviruses in those organs, evaluating their viability over several days. (nih.gov)

This assay has been used as a screening and confirmation tool for Flavivirus presence in laboratory and field samples, and it performed successfully in international External Quality Assessment of NAT studies. (hindawi.com)