Does adipocyte hypercellularity in obesity exist?

AUTHOR(S)

Jung, R.T.; Gurr, M.I.; Robinson, M.P.; James, W.P.T.

PUB. DATE

July 1978

SOURCE

British Medical Journal;7/29/1978, Vol. 2 Issue 6133, p319

SOURCE TYPE

Academic Journal

DOC. TYPE

Article

ABSTRACT

Examines the existence of adipocyte hypercellularity in obese person. Calculation of the fat cells in obese patients; Basis of the omental fat cells; Unreliability on the diagnosis of hyperplastic obesity.

Background: A reduction of dopaminergic (DAergic) activity with increased prolactin levels has been found in obese and hypertensive patients, suggesting its involvement as a pathophysiological mechanism promoting hypertension. Similarly, leptin action increasing sympathetic activity has been...

The article discusses new research which shows that predicting a person's long-term health may be as simple as taking a waist measurement. Fat around the waist has been linked to a greater risk of heart disease, diabetes, stroke, hypertensin, some cancers, and higher mortality rates. The more...

Obesity is a chronic disease with multiple origins. It is a widespread global phenomenon carrying potentially serious complications which requires a multidisciplinary approach due to the significant clinical repercussions and elevated health costs associated with the disease. The most recent...

OBJECTIVE:To investigate changes in adipocyte hormones and lipid oxidation during and after a weight-reduction programme in severely obese adolescents.DESIGN:Longitudinal-clinical investigation including a 9-month multidisciplinary weight-reduction programme in a specialised institution with...

We sought to assess whether direct uptake of circulating free fatty acids (FFAs) by adipocytes occurs in vivo in overnight postabsorptive humans and, if so, whether there are regional differences in uptake between lean and obese women and men. We used bolus injections of radiolabeled FFA tracers...

The article presents research brief, which states that raised levels of inflammatory proteins produced by subcutaneous fat could be responsible for increased morbidity associated with obesity. Researchers sampled subcutaneous fat from 20 overweight or obese women aged over 65.

The article discusses theories about what may be contributing to the obesity epidemic in the U.S. While overweight people are often viewed as having weak willpower, the author attests that this may not be the case. It is suggested that viruses in food may infiltrate adult stem cells and...