Mark is upset that Addie has taken a leave of absence and is leaving for Los Angeles. Meanwhile, Meredith’s stepmother comes in to Seattle Grace because her hiccups won’t go and has to undergo surgery.

Some recent events put a strain on the relationship between Cristina and Preston, Meredith’s half-sister is admitted to Seattle Grace, and Derek and Mark encounter patients who are brothers with a very complicated case.

The male medical staff of Seattle Grace goes on a camping trip, Addie and Callie are forced to work on a similar case, Meredith and Sloan attempts a surgery never before done, and Bailey and Cristina discuss the latter’s recent actions.