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The Consequences of Valproate Overdose

A 43-year-old man with epilepsy who had been treated with valproic acid (Depakote®) (VPA)2 for 13 years and had a history of multiple suicide attempts and alcohol dependence presented after ingesting an overdose of VPA and ibuprofen. The patient was not on any other prescribed medications. At presentation, the patient exhibited the following: Glasgow Coma Score (GCS), 3/15 (3 being the worst, indicating full coma, and 15 being a normal mental state); heart rate, 96 beats/min; blood pressure, 121/79 mmHg; temperature, 36.5 °C; oxygen saturation, 97%.