FALL and Cymbalta

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FALL Symptoms and Causes

Falls can be dangerous at any age. Babies and young children can get hurt Falling off furniture or down the stairs. Older children may Fall off playground equipment. For elderly people, Falls can be especially serious. They are at higher risk of Falling. They are also more likely to break a bone when they Fall, especially if they have osteoporosis. A broken bone, especially when it is a hip, may even lead to disability and a loss of independence for the elderly.

Some common causes of Falls include

Balance problems

Some medicines, which can make you feel dizzy, confused, or slow

Vision problems

Alcohol, which can affect your balance and reflexes

Muscle weakness, especially in your legs, which can make it harder for you to get up from a chair or keep your balance when walking on an uneven surface.

Certain illnesses, such as low blood pressure, diabetes, and neuropathy

Slow reflexes, which make it hard to keep your balance or move out of the way of a hazard

Tripping or slipping due to loss of footing or traction

At any age, people can make changes to lower their risk of Falling. It important to take care of your health, including getting regular eye exams. Regular exercise may lower your risk of Falls by strengthening your muscles, improving your balance, and keeping your bones strong. And you can look for ways to make your house safer. For example, you can get rid of tripping hazards and make sure that you have rails on the stairs and in the bath. To reduce the chances of breaking a bone if you do Fall, make sure that you get enough calcium and vitamin D.

FALL Clinical Trials and Studies

Treatments might be new drugs or new combinations of drugs, new surgical procedures or devices, or new ways to use existing treatments. The goal of clinical trials is to determine if a new test or treatment works and is safe. Clinical trials can also look at other aspects of care, such as improving the quality of life for people with chronic illnesses. People participate in clinical trials for a variety of reasons. Healthy volunteers say they participate to help others and to contribute to moving science forward. Participants with an illness or disease also participate to help others, but also to possibly receive the newest treatment and to have the additional care and attention from the clinical trial staff.

To estimate the risk of major congenital anomalies among pregnancies exposed to Cymbalta; To estimate risk of recognized spontaneous abortions, stillbirths, elective terminations, minor congenital anomalies, and any serious adverse pregnancy outcomes among pregnancies exposed to Cymbalta and their live births during the first year of life; To examine any potential impact of Cymbalta use while breastfeeding on the infant during the first year of life; To compare the risk of major congenital anomalies among pregnancies exposed to Cymbalta to an appropriate comparator(s) such as the Centers for Disease Control and Prevention (CDC) Metropolitan Atlanta Congenital Defects Program (MACDP)

The effects of response to treatment with duloxetine on brain structure and activation in subjects (peri- and postmenopausal women with MDD).; Changes in brain activation in remitters versus non-remitters after treatment with duloxetine (remission of depression defined MADRS total score <10 at study end).; Correlations between changes in brain activation and changes from baseline to study end and menopausal symptoms, depressive symptoms, cognition, quality of life, and clinical global impression (improvement and severity).

The primary clinical efficacy measure is reduction in spontaneous (non-evoked) pelvic pain. This will be assessed by using the 0-10 numerical pain ratings to derive the primary outcome variable of clinical pain intensity difference due to treatment.; Functional limitations due to pain

Reduction in average joint pain according to BPI-SF assessed up to 12 weeks; Reduction in worst joint pain according to the BPI-SF worst pain score assessed up to 12 weeks; Reduction in pain interference according to the BPI-SF worst pain score assessed up to 12 weeks

If you think you may have a medical emergency, call your doctor or 911 immediately.

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