Most words of Native American/First Nations language origin are the common names for indigenous flora and fauna, or describe items of Native American or First Nations life and culture. Some few are names applied in honor of Native Americans or First Nations peoples or due to a vague similarity to the original object of the word. For instance, sequoias are named in honor of the Cherokee leader Sequoyah, who lived 2,000 miles east of that tree's range while the kinkajou of South America was given a name from an unrelated North American animal 2,000 miles to the north.

Since Native Americans and First Nations peoples speaking a language of the Algonquian group were generally the first to meet English explorers and settlers along the Eastern Seaboard, many words from these languages made their way into English.

From Old Montagnaisaiachkimeou ([aːjast͡ʃimeːw]; modern ayassimēw), meaning "snowshoe-netter" (often incorrectly claimed to be from an Ojibwe word meaning "eaters of raw [meat]"), and originally used to refer to the Mikmaq.[16][17]

Words of Nahuatl origin have entered many European languages. Mainly they have done so via Spanish. Most words of Nahuatl origin end in a form of the Nahuatl "absolutive suffix" (-tl, -tli, or -li, or the Spanish adaptation -te), which marked unpossessed nouns.

Often said to be from Nahuatl xocolātl[38] or chocolātl,[83] which would be derived from xococ "bitter" and ātl "water" (with an irregular change of x to ch).[84] However, the form xocolātl is not directly attested, and chocolatl does not appear in Nahuatl until the mid-18th century. Some researchers have recently proposed that the chocol- element was originally chicol-, and referred to a special wooden stick used to prepare chocolate.[85]

^Chamberlain, Alexander F. (1902). "Algonkian Words in American English: A Study in the Contact of the White Man and the Indian". The Journal of American Folklore. 15 (59): 240–267. doi:10.2307/533199. JSTOR533199.

Siebert, Frank T. (1975). "Resurrecting Virginia Algonquian from the Dead: The Reconstituted and Historical Phonology of Powhatan". In Studies in Southeastern Indian Languages, ed. James M. Crawford, pp. 285–453. Athens: University of Georgia Press