We present the state-of-the-art in direct RNA modification as well as the challenges that hold back further development of RNA mechanistic probes and medicines. Solid-phase synthesis has revolutionized the synthesis of short DNAs and RNAs. Many open questions in RNA biology are with
large long-non-coding RNAs or mRNAs and there is also interest in developing these big RNAs as medicines. Techniques for direct modification will become more important in the coming years and we give a current snapshot of the field here, with a bias towards our own contributions.

Affiliations:1: Department of Chemistry, University of Basel St. Johanns-Ring 19, CH-4056 Basel;, Email: [email protected]2: Department of Chemistry, University of Basel St. Johanns-Ring 19, CH-4056 Basel

Publication date: 01 November 2018

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International Journal for Chemistry and Official Membership Journal of the Swiss Chemical Society (SCS) and its Divisions

CHIMIA, a scientific journal for chemistry in the broadest sense, is published 10 times a year and covers the interests of a wide and diverse readership. Contributions from all fields of chemistry and related areas are considered for publication in the form of Review Articles and Notes. A characteristic feature of CHIMIA are the thematic issues, each devoted to an area of great current significance.