The second domain of TFIIH p62 (zeige GTF2H1 Proteine) subunit(residues 186-240) contains a region of high sequence conservation with an invariant tyrosine/phenylalanine motif which could play a key role as a protein-protein recognition module within TFIIH (zeige GTF2H1 Proteine).

mechanism in which the helicase activity of XPB (zeige GTF2H5 Proteine) is not used for the opening and repair of damaged DNA, which is instead only driven by its ATPase activity, in combination with the helicase activity of XPD (zeige ERCC2 Proteine)