..Taken together, colon cancer-derived factors induce the accumulation of macrophages and activate NF-κB through a TLR2-dependent mechanism, suggesting an important link between inflammation and tumor growth...

Yoku HayakawaDepartment of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Bunkyo ku, Tokyo, JapanInfect Immun 81:4551-60. 2013

..The balance of ASK1-induced apoptosis and TAK1-induced antiapoptotic or inflammatory responses may determine the fate of epithelial cells infected with H. pylori and thus be involved in the pathogenesis of gastritis and gastric cancer. ..

..Apoptosis signal-regulating kinase 1 (ASK1) is a MAPK kinase kinase; little is known about the role of ASK1 in colonic disease. We assessed the involvement of ASK1 in the development of intestinal inflammation and CAC...

Gastric cancer risk according to the distribution of intestinal metaplasia and neutrophil infiltration

Kosuke SakitaniDepartment of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, JapanJ Gastroenterol Hepatol 26:1570-5. 2011

..We aimed to elucidate the association between gastric cancer risk and the distribution of precancerous lesions in the stomach by histological analyses...

..Nuclear factor-kappaB (NF-kappaB) is an important transcription factor involved in various biological processes, including carcinogenesis. However, it is unknown whether NF-kappaB activation is involved in gastric carcinogenesis...

Activation of IkappaB kinase and NF-kappaB is essential for Helicobacter pylori-induced chronic gastritis in Mongolian gerbils

..017) between the groups, but not for undifferentiated cancer (P=0.847). The results of the current study suggest that the eradication of H. pylori infection reduces the incidence of gastric cancer...

Yuji OgawaDepartment of Gastroenterology, Yokohama City University Graduate School of Medicine, Yokohama, JapanPLoS ONE 8:e65211. 2013

..Therefore, the aim of this study was to investigate the relationship between soluble type of CD14 (sCD14) and histological features in patients with NAFLD...

Role of interleukin-32 in Helicobacter pylori-induced gastric inflammation

Kosuke SakitaniDepartment of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, JapanInfect Immun 80:3795-803. 2012

..We also found that NF-κB activation was decreased in H. pylori-infected IL-32-knockdown cells. These results suggest that IL-32 has important functions in the regulation of cytokine expression in H. pylori-infected gastric mucosa...

Apoptosis signal-regulating kinase-1 inhibitor as a potent therapeutic drug for the treatment of gastric cancer

Yoku HayakawaDepartment of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, JapanCancer Sci 103:2181-5. 2012

..These results indicate that ASK1 inhibition prevents GC cell growth in vitro and in vivo, suggesting that ASK1 inhibitors can be potent therapeutic drugs for GC...

Effect of sumatriptan on gastric emptying: a crossover study using the BreathID system

..The aim of the present study was to evaluate these candidates in nuclear factor (NF)-kappaBeta activation, which is a critical regulator of genes involved in inflammatory reactions...

Early effect of oral administration of omeprazole with mosapride as compared with those of omeprazole alone on the intragastric pH

Hiroshi IidaYokohama City University School of Medicine, Yokohama, JapanBMC Gastroenterol 12:25. 2012

..The aim of our study was to comparatively investigate the inhibitory effect on gastric acid secretion of a single oral administration of omeprazole plus mosapride with that of omeprazole alone...

Use of contrast-enhanced ultrasonography with a perflubutane-based contrast agent performed one day after transarterial chemoembolization for the early assessment of residual viable hepatocellular carcinoma

Ryota TakahashiDepartment of Gastroenterology, Graduate School of Medicine, The University of Tokyo, TokyoCancer Sci 104:337-44. 2013

..Angiogenesis was also decreased by JNK inhibition in vitro and in vivo. In conclusion, activation of JNK promotes development of pancreatic cancer, and JNK may be a potential therapeutic target for pancreatic cancer...

Sitafloxacin resistance in Helicobacter pylori isolates and sitafloxacin-based triple therapy as a third-line regimen in Japan

..IKKalpha nuclear translocation induced by H. pylori is indispensable for appropriate inflammatory responses but not for antiapoptosis, which suggests a critical role for IKKalpha in gastritis development...

Use of fusion imaging combining contrast-enhanced ultrasonography with a perflubutane-based contrast agent and contrast-enhanced computed tomography for the evaluation of percutaneous radiofrequency ablation of hypervascular hepatocellular carcinoma

..pylori. In conclusion, H. pylori induces antiapoptosis through c-IAP2 transactivation following cagPAI-dependent NF-kappaB activation. The interaction of these stimuli may play a role in gastric carcinogenesis...

Efficacy and safety of faropenem in eradication therapy of Helicobacter pylori

..To seek a better regimen for eradication therapy, we assessed the sensitivity of clinical strains seen in Japan to faropenem and then evaluated the efficacy and safety of eradication therapy containing this antibiotic...

..The aim of our study was to investigate the inhibitory effects on gastric acid secretion of a single oral administration of a proton pump inhibitor, omeprazole 20 mg, and an H(2)-receptor antagonist, roxatidine 75 mg...

A new non-invasive modality for recording sequential images and the pH of the small bowel

Hiroshi IidaYokohama City University School of Medicine, Yokohama, JapanHepatogastroenterology 59:413-4. 2012

..The aim of this study was to investigate the relationship between small bowel disease and the small bowel pH, we designed a new modality, the 'pH capsule', to non-invasively record sequential images and the pH...

..We evaluated the usefulness of color Doppler flow imaging to compensate for the inadequate resolution of the ultrasound (US) monitoring during high-intensity focused ultrasound (HIFU) for the treatment of hepatocellular carcinoma (HCC)...

Factors predicting the presence of small bowel lesions in patients with obscure gastrointestinal bleeding

..The aim of this study was to determine whether single pre-prandial sitagliptin, the DPP-IV inhibitor, administration might have an effect on the rate of liquid gastric emptying using the (13)C-acetic acid breath test...

Influence of Helicobacter pylori eradication on the management of type 2 diabetes

..In addition, the number of patients with type 2 diabetes is increasing worldwide. The aim of this study was to understand the influence of H. pylori eradication therapy on the management of type 2 diabetes...

..These results indicate an autoregulatory mechanism of ASK1 in the development of gastric cancer. Targeting this positive feedback loop, ASK1 may present a potential therapeutic target for the treatment of advanced gastric cancer...

Reduced expression of RAS protein activator like-1 in gastric cancer

Motoko SetoDepartment of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, JapanInt J Cancer 128:1293-302. 2011

..Our findings demonstrate that reduced RASAL1 expression, partly due to genetic and epigenetic changes, contributes to gastric carcinogenesis, and also re-emphasize the importance of RAS signaling in gastric cancer development...

Doppler ultrasound findings correlate with tissue vascularity and inflammation in surgical pathology specimens from patients with small intestinal Crohn's disease

..pylori possessing intact cag PAI. SRE is required for the activation of c-fos by H. pylori. These results suggest a direct involvement of H. pylori infection in cellular proliferation, which may play a role in neoplastic transformation...

Tomoyuki IwasakiYokohama City University Graduate School of Medicine, Yokohama, JapanHepatogastroenterology 58:2103-5. 2011

..However, no effective drug therapy for NAFLD has been established yet. In the present study, we evaluated the efficacy of 4 months of treatment with sitagliptin in NAFLD patients with type 2 diabetes mellitus (DM)...

Usefulness of US-CT 3D dual imaging for the planning and monitoring of hepatocellular carcinoma treatment using HIFU

..The present study was conducted with the aim of determining whether high-viscosity liquid meals had any effect on the rate of gastric emptying and mosapride might accelerate the rate of gastric emptying of high-viscosity liquid meals...

..Studies about risk factors, other than nonsteroidal anti-inflammatory drugs, for colonic diverticular hemorrhage are limited. We conducted the present study to elucidate their significance as a risk factor...

[Helicobacter pylori virulence factors except CagA]

Shin MaedaDepartment of Gastroenterology, University of TokyoNihon Rinsho 67:2251-6. 2009

..Signaling pathway via toll-like receptors(TLR) is also thought to be important especially in myeloid cells even though bioactivity of H. pylori LPS is reported to be weak compared with other bacteria such as E. coli...

Influence of pretreatment with H2 receptor antagonists on the cure rates of Helicobacter pylori eradication

..pylori eradication has not yet been studied. We compared the efficacy of eradication regimen (lansoprazole/amoxicillin/clarithromycin) in patients with H. pylori infection with or without H2RA pretreatment...

Clostridium difficile infection in patients with ulcerative colitis: investigations of risk factors and efficacy of antibiotics for steroid refractory patients