Funding

Training

Instruct supports scientists in exploring their science from helping students understand the core principles of Structural Biology to building a vision of the Grand Challenges our science must resolve.

"Integrated Structural Biology is at a critical stage; failure is not an option..."

Prof. Dave Stuart

Instruct Hub

Your Career

Information

Instruct will foster greater cooperation to encourage innovation, make investments more effective, and improve our ability to solve problems. We build meaningful long-term collaborations with industry and academia that lead to translatable scientific advances.

Press

Media

Network

Be part of our thriving community of scientists who use integrated structural biology to further the frontiers of science. Help solve the grand challenges facing society by pushing the boundaries of existing scientific disciplines and expertise.

Our Infrastructure

CCP4 Online

CCP4 is a software suite for Macromolecular X-Ray Crystallography, for every stage of the crystallographic structure solution process, from processing X-ray diffraction images through to producing images and movies for presentations and publications.

Balbes

An automated Molecular Replacement (MR) pipeline – Balbes integrates into one system all the components necessary for solving a crystal structure by Molecular Replacement

MrBUMP

An automated Molecular Replacement (MR) pipeline – Given a target sequence and experimental structure factors, it will search for homologous structures, create a set of suitable search models from the template structures, do molecular replacement, and test the solutions with some rounds of restrained refinement.

CRANK2

MoRDa

MoRDa is a pipeline for molecular replacement protein structure solution based on its own domain database. Models relevant to the target sequence are further adjusted before molecular replacement search. BETA