Recently, azole-resistant Aspergillus fumigatus containing a 34-bp or 46-bp tandem repeat in the promoter region of cyp51A combined with amino acid substitution(s) has appeared in the environment worldwide, including several Asian countries. In this study, we isolated the 34-bp tandem repeat-containing azole-resistant A. fumigatus strain OKH50 from a patient in Japan in May 2016. The patient had not been treated with medical azoles before the strain isolation, suggesting that the resistant property was acquired before infection. In addition, the patient had not traveled overseas. Our analysis of short tandem repeats of the strain indicates that the strain is strongly related to the 34-bp tandem repeat-containing isolates from European countries and Asia-Oceania countries but not to susceptible isolates from Japan, suggesting that the strain was introduced from overseas and might spread in Japan. c 2016 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases

雑誌名

Journal of Infection and Chemotherapy

巻

23

号

8

ページ

579 - 581

発行年

2017

出版者

Elsevier B.V.

ISSN

1341321X

書誌レコードID

AA11057978

DOI

info:doi/10.1016/j.jiac.2016.12.004

権利

This accepted manuscript is licensed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. <http://creativecommons.org/lisenses/by-nc-nd/4.0/>

Obihiro University Archives of Knowledge, OAK, is an open access repository at The Obihiro University of Agriculture and Veterinary Medicine. The aim of the archive is to collect the fruits of its education and research, and to make them openly available via the internet.

帯広畜産大学学術情報リポジトリ（OAK）は，2018年2月13日より現在のアドレスに移行しました。旧ドメイン（http://ir.obihiro.ac.jp/）のアドレスは，自動的に現ドメインのトップページにリダイレクトされます。OAK, obihiro university archives of knowledge, migrated to current url at 13th February, 2018. Access to old domain (http://ir.obihiro.ac.jp/) is redirected to new domain.