Born, raised and educated in Brooklyn, New York, Sandy Baron worked summers at the famed Catskill Mountain resorts where many Jewish comedians got their starts. His own aspirations were realized when he made his Broadway debut in 1962 in Tchin-Tchin.

By 1964, he was an established Catskill and nightclub entertainer and came to national attention with his contributions to That Was the Week That Was, a British import which lampooned newsmakers and starred David Frost. His next move was to star in his own television series, Hey, Landlord which lasted one season. He made regular appearances on the talk shows hosted by Mike Douglas and Merv Griffin.

He appeared in a number of films including If It's Tuesday, This Must Be Belgium, The Grifters and The Munsters' Scary Little Christmas. He appeared as himself in Woody Allen's Broadway Danny Rose.

His television appearances varied from drama to comedy and included roles on Starsky and Hutch, Law & Order and a recurring role as Jack Klompus on Seinfeld.