NINDS requests applications for ancillary studies in immunomodulation clinical trials. This announcement is made together
with 3 other NIH components.

The initiative supports mechanistic studies in clinical trials of immunomodulatory interventions for immune system-mediated
diseases, and preventative and therapeutic vaccines for non-HIV/AIDS infectious diseases. The goal is to include subjects
and use samples from clinical trials for evaluating immunologic and other relevant parameters to study and define the underlying
immunological mechanisms of intervention or vaccine, mechanisms of disease pathogenesis, biomarkers of disease activity and
therapeutic effect, and mechanisms of human immunologic function.