Inhibition of BNIP-2 expression did not affect the susceptibility to NK cell-mediated killing.

Transfection of the bnip2 cDNA in neuroblastoma (show ARHGEF16 ELISA Kits) cell line results in massive cell death counteracted by Bcl-2 (show BCL2 ELISA Kits) overexpression; bnip2 is the mediator of the anti-apoptotic activity of estrogens in a variety of cells

Our results suggest that the caspase (show CASP3 ELISA Kits)-mediated cleavage of BNIP-2 and BNIP-XL could result in the release of the BCH (show CHN2 ELISA Kits) domain or smaller fragments that are crucial for their proapoptotic activities.

Antigen Summary

This gene is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. It interacts with the E1B 19 kDa protein, which protects cells from virally-induced cell death. The encoded protein also interacts with E1B 19 kDa-like sequences of BCL2, another apoptotic protector.