It's usually better and faster, if problems get first addressed in the forums (https://forums.virtualbox.org/). More than 95% of the issues are resolved over there, which keeps the developers focusing on the bug fixes and enhancements, and there is no need for another ticket to keep track of. For example, yours is already reported several times and someone from the developers has to deal with it and close it as "Duplicate".

Turns out that this ticket may have the same symptoms as the other ones, but it actually stands on its own and it's not a duplicate. The offending instruction is "movups xmm" as it was reported and confirmed, after 5.1.22 was released in the 5.1.x Guru Meditation: VERR_IEM_INSTR_NOT_IMPLEMENTED.

Add another report of a fixed problem on an iMac17,1, with an ArchLinux_64 guest "choking" on instruction "vmovdqa oword", reported as Guru Meditation with 5.1.22, but fixed with the "latest" build (whatever "latest" means). At the time of this writing, "latest" == r115966.