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In the past 2 years I have learned that Photoshop isn’t meant for webdesign. And layer comps suck bigtime when you need to change something afterwards.

You definitely should give Fireworks a go. It uses pages. Has find and replace (not only for text, also for colors(!)).
And then there’s symbols. You got to love it. Change a symbol and it’s changed everywhere. It will give you a month extra time every year. Hooray! I can’t emphasize it more – use Fireworks CS5! It runs smooth and the learning curve is not that steep. Command+K snaps your object to pixels for instance, no more fuzzy aliassing! It even has automated back-ups in case of crashes.