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4-(4-Formyl-3-methoxyphenoxy)ethyl (“FMP”) Resin

Chemfiles Volume 3 Article 4

Dialkoxybenzaldehyde resin can be used for the production of C-terminal peptide N-alkylcarboxamides and peptide esters similar to the trialkoxybenzaldehyde-type backbone amide linker (BAL).(1-2) Reductive amination of the resin introducing a primary amine or an amino acid alkyl ester provides a polymer-bound secondary amine that is readily acylated employing activation by HATU/diisopropylethylamine. Cleavage of the C-terminal modified peptide is accomplished with 95% trifluoroacetic acid.