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long term effects= depression, chronic fatigue, loss of appetite, etc. mdma is murderous on your serotonin and it will eventually exhaust your serotonin system. Of course its different for every person so the time it takes to do so will vary greatly.Mushrooms seem to have no mood altering affects afterwards that ive really noticed, even after doses as high as 10g dry. (well its probly because im squatted over the toilet, crying, shooting rpg's out of my ass)

--------------------I often come to many challenges and intimidations, but then I remember that you only live life once, one single time through, with no reruns or rehearsals. So just live the way you want and the best you can. Its easy.

Take a look at Ecstasy Rising (an ABC Peter Jenning's special report which is featured on Erowid). You can watch it here.

Also, this quote might be of interest to you.

Quote:Jennings described the far more rigorous study published in 2003 by Buchert et al. of Hamburg, Germany which, Jennings says, "found only a slight, 5% loss of serotonin function" that "may be reversible". According to Mark Laruelle of the NY State Psychiatric Institute, a "leading brain imaging expert" referring to the Buchert study, "in people who had used ecstasy, but who had stopped taking ecstasy for two or three months, normal serotonin function was found. There was indeed a reduced serotonin function but that reduction may be reversible after 2-3 months of abstinence."