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Cyclo(His-Gly) inhibited the growth of MCF-7 cancer cells in vitro and showed antithrombotic effects.
Cyclo-(His-Gly), which is related to anorexigenic peptide, was shown to inhibit release of catecholamine and norepinephrine in vitro significantly. The diketopiperazine could play a role in the hypothalamic modulation of appetite suppressant circuitry.