I have a few colleagues in psychiatry and have heard them say that the problem with these researches is that intersexual people are usually included in them, as they go through same psychiatric hospitals as transsexuals, and intersexuals far more commonly have second-doubts about their treatments. Of course they can't talk that much about their patients, but one of them said that almost all of the intersexuals have had some regrets while the transsexuals not really, and those who did, it's been because of surgery complications.
Personally I think long-term reasearch would be preferable, since any big surgery leaves you feeling blue for a while.

Don't get me wrong, gender reassignment can absolutely do more harm than good, to themselves. I was speaking more along the line of the kind of intolerance that objects to their very existence. If they're not hurting anybody then why even care? Let people live how they want to live and all that jazz.

People with other mental issues that don't pose a threat to anyone, are seen as victims in need of help. They're not told that there's nothing wrong with them, and that their ailment isn't something to be helped.

Hell, I'll even go as far as to compare the whole thing to pedophilia. Yup, I know it's extreme, but fuck it. Non-child-molesting pedophiles, who would never actually perform acts with children, are seen as not only people in need of help, but are villified and seen as a major problem in society. I'd argue that, since a lot of people are bothered by this mental gender culture we have, either from annoyance due to the kind of people that usually have it, or because they find it strange and don't want it around them, it's not really up to the individuals with the issues to decide whether it's a non-issue. I mean, pedophiles that don't hurt anyone don't get to decide that what they suffer from is normal, and that they can be open about it in society.