Set at the dawn of modern psychiatry in the late 19th and early 20th centuries, British author Faulks's vast, elegant novel follows two "mad-doctors," Thomas Midwinter and his close friend Jacques Rebière, as they struggle to contribute something great to the emerging discipline. A chance meeting in 1880 leads to a lifelong partnership that lasts through journeys around the Continent and across the Atlantic. The pair vow to unlock the secrets of consciousness, and the novel traces their experiences in the hellish asylums of the day and their diverging approaches to the field. As Jacques grows interested in the Viennese school of psychoanalysis and talk therapy, Thomas focuses on the neurological and evolutionary mechanisms that lead to psychosis. Faulks (Birdsong ) shines in his dramatization of Thomas's lectures, presaging contemporary arguments about chemical imbalances. While his characters attempt to discover what makes us human, Faulks also meticulously depicts grief, longing, nostalgia and melancholy through a portrait of Thomas's sister, Sonia. Faulks marries extensive research with a satisfying narrative arc to create a novel that is compelling as both history and literature. (Sept.)