actinomycin

actinomycin

(ăk'tənōmī`sən), any one of a group of antibioticsantibiotic,any of a variety of substances, usually obtained from microorganisms, that inhibit the growth of or destroy certain other microorganisms. Types of Antibiotics.....Click the link for more information. produced by bacteria of the genus Streptomyces. Actinomycin was the first antibiotic reported to be able to halt cancer; however, it is not widely used to treat cancers because it is highly toxic to humans, interfering with the genetic material of cells. It is mainly used as an investigative tool in cell biology.

actinomycin

[‚ak·tə·nō′mī·sən]

(microbiology)

The collective name for a large number of red chromoprotein antibiotics elaborated by various strains of Streptomyces.

Among the moderately gonadotoxic agents are cisplatin and adriamycin, while bleomycin, actinomycin D, vincristine, methotrexate, and 5-fluorouracil are associated with mild or no gonadotoxicity (Table 2).

11) The role of chemotherapy is controversial, (16) although Lenoir et a1 (12) reported a dramatic regression in tumor size in a 15-month-old patient with a retropharyngeal synovial sarcoma after treatment with a combination of ifosfamide, vincristine, and actinomycin D.

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