In this review, the doctors provide updates on seven different studies on new therapeutics in myelodysplastic syndromes (MDS), as part of The ASCO Post’s continued coverage of the 2018 American Society of Hematology (ASH) Annual Meeting & Exposition. Among the treatments highlighted here are the erythroid maturation agent luspatercept, the Toll-like receptor 2 antibody tomaralimab, the XPO1 inhibitor selinexor, and the DNA methyltransferase inhibitor guadecitabine.