I have been able to run this using VWware Fusion with Windows XP for several years. Currently on Mac OS 10.9 with Fusion v4.1
Even works with a Wacom tablet!
I would be interested to know if anyone has this running using Wine on OSX, or any other way on OS X. The game makes my fans run on high whenever I'm in the game, and the chassis gets pretty warm, so I am exploring other ways to run it.

I've been able to make both paid versions of spWW2 and spMBT to run very smoothly and no crashes with an iMAC running OSX Mavericks installing and using through WINE.

There was no need to do any special Winetricks but it was very important to use the engine version WS8Wine1.4 and not any other. Trying to use any older Wine engine and there were problems with the graphics getting all messy or the game not running at all. Trying any newer Wine engine than 1.4 caused the game to run very slowly, all the actions having a terrible delay.

In Wine's 'Set Screen Options' I just use Automatic settings. From smWW2/spMBT launchers I use 'Fullscreen', 'DirectX' and screen size 'Desktop'.