Nursing Faculty Universityof North Sumatera implement a learning system CBC on undergraduate education students in 2010 and 2011 force to improvethe quality of graduates based on the competency of nursing practice.Requirements andlearning system CBC could be as tressor that triggersstress occuron college students and the activeefforts that conducted by college studentcalledcoping. The aim of this research was to obtain stressorsandcopingdescription of collegestudentlearningbased curriculum Nursing FacultyUniversityof NorthSumatra. The research designwasexploratorydescriptiveby using stratified randomsampling. The sample sizeis usedas many as66 people. Instrument of this research is demographic dataquestionnaire, college studentquestionnairesstressorandopen-ended questionsregardingcopingused. Datacollectionwas conducted from may until June 2012. Results showedthatcollege studentsexperience stresswhile attendingCBClecturesand doing spesific effort to overcome.The conclusion ofthis research isa majorstressorthat complained byCBC college studentsarepreparing forthe block exam(75.75%) andcopingfunctionswhich used are focuseson emotionsthatescapeavoidance(59.09%). Nursing educationinstitutionsneed to provide acounseling program to help college student with problems in education, divided college student into two classes so that the class is not to full and supply facilities and infra structure needed in the classroom.