SUTENT 12.5MG

Description

Sunitinib is an anti-cancer drugs which prohibits the development and spread of cancer cells in the body.

Sutent 12.5mg is a is an oral, small-molecule, multi-targeted receptor tyrosine kinase (RTK) inhibitor which was approved by the FDA for the therapy of renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST).

Sutent 12.5mg is a prescription drugs which is used under the guidance of medical practioners

Indication

Sutent 12.5mg is indicated for the treatment of advanced renal cell carcinoma as well as the treatment of gastrointestinal stromal tumor after disease progression on or intolerance to imatinib mesylate.

Pancreatic Neuroendocrine Tumor

The usual dose is 37.5 mg PO qDay continuously without a scheduled off-treatment period

Mechanism of action

Sunitinib belongs to the kind of tyrosine kinase inhibitor. Its action by inhibiting indicating in cancer cells which make them grow and divide. This may help to blocks the cancer developing or slow it down.

Sunitinib can also block cancer cells from developing new blood vessels. This decrease their supply of oxygen and nutrients, so the tumor shrinks or stops developing.

ADME Properties

Time to plasma concentration of sunitinib is between 6 and 12 hours and the bioavailability of sunitinib has no effect on food.

Pregnancy

Advise females of reproductive possible of the probable hazard to a foetus and use of effective contraception. In pregnant women there is no available data established by along risk in animal development and reproductive studies.

Lactation

Decision should be taken about discontinue the nursing or to stop the drug considering the important of the drug to the mother.

Possible of severe side effects in breastfed infants from sunitinib, avoid breast feeding during treatment.

Storage

Stored at controlled temperature at 250C

Dispense only in its original carton

Missed dose

If dose is forgot to take, then have the dose immediately before next dose timing reaches or skip the missed dose and continue the regular schedule.