NON-INVASIVE DIAGNOSTIC METHOD FOR THE EVALUATION OF INTESTINAL LACTASE DEFICIENCY (HYPOLACTASIA) - The test of the invention comprises the measuring the total amount of xylose in urine and/or its concentration in blood following oral administration of 4-O-β-D-galactopyranosyl-D-xylose (4-GX) to the patient. It is a non-invasive test that is based on the direct evaluation of the global enzyme activity in the whole individual, not on measuring the metabolic consequences derived from its deficiency. It does not require specialised equipment, does not cause apparent discomfort in patients with lactase deficiency and is very reliable, thus overcoming the drawbacks of the diagnostic tests currently in use and is a statistically significantly better test in terms of its reliability; consequently it should become the reference or gold standard test for the indication of hypolactasia.

HYDROGEN PEROXIDE SENSORS BASED UPON PHOTO-INDUCED ELECTRON TRANSFER - The invention provides compounds of formula I F-L-Q (I) where F comprises a fluorophore capable of absorbing energy at an excitation wavelength and, in the absence of a quencher, emitting energy at an emission wavelength, which is different than the excitation wavelength; Q comprises a quencher; L comprises a linker moiety having two ends, one end being covalently bound to F and the other end being covalently bound to Q. The compounds are capable of undergoing a reversible reaction (1), provided below: (1) where Q

2012-07-19

20120183985

METHOD FOR THE MANUFACTURE OF MICROTISSUES FOR INDUCING THE GROWTH OF A HAIR FOLLICLE - Disclosed is a method for the manufacture of microtissues, comprising the steps of: providing a biomaterial substrate; simultaneously seeding a plurality of dermal papilla (DP) cells and keratinocytes on the substrate surface with a predetermined ratio and cellular density; co-culturing for a predetermined period; and carrying the keratinocytes to the substrate surface by the dermal papilla cells, aggregating and finally form a plurality of keratinocyte-dermal papilla cell microtissues, wherein the dermal papilla cells are located in a centre of the microtissue and the keratinocytes are sorted to a surface of the microtissue, and the keratinocytes are adult keratinocytes. The method can help to simply and economize the procedures for production of folliculoid microtissues with high-throughput. Once microtissues are transplanted to skin of subject, hair follicles can be regenerated.

METHOD FOR CULTURE OF HEPATOCYTES - A method for culturing hepatocytes, wherein hepatocytes embedded in an extracellular matrix is placed on a gas-permeable membrane and the hepatocytes are cultured while being supplied with oxygen from the gas-permeable membrane side. By this, the polarity in the hepatocytes can be induced and a bile canaliculus can be formed in a short period of time. Further, the formed polarity can be maintained for a longer period.

2012-07-19

20120183990

MICROFLUIDIC SYSTEM AND METHOD FOR PRODUCING SAME - A closed microfluidic system is equipped with a carrier plate and a cover plate as well as wall regions arranged therebetween, which form a system of channels and/or cavities with an inner surface. Selected regions of the inner surface are selectively functionalized.

Reagents and Methods for Classifying Leukocytes - A reagent for classification of leukocytes includes (a) at least two cationic surfactants; (b) at least one organic compound bearing a hydrophobic group and an anionic group; (c) a buffer for adjusting pH into a range of approximately 2-8. Also disclosed is a method for classifying leukocytes with the reagent. With the reagent and method, erythrocytes are lysed rapidly and classification of leukocytes into five groups is achieved in the same channel. The reaction may be carried out at approximately between 10-40° C. and scattered light signals may be detected at two angles for measuring the classification of leukocytes into five groups.

ENHANCED PROTEIN EXPRESSION IN BACILLUS - The present invention provides cells that have been genetically manipulated to have an altered capacity to produce expressed proteins. In particular, the present invention relates to Gram-positive microorganisms, such as

Modified Promoter - The present invention provides a modified promoter, an expression vector and a transformant each containing the promoter, and a method for producing a gene product of interest using the transformant. The invention provides a modified promoter, including a nucleotide sequence of a promoter derived from bacterium belonging to the genus

2012-07-19

20120183999

USE OF MULTIPLE RECOMBINATION SITES WITH UNIQUE SPECIFICITY IN COMBINATIONAL CLONING - The present invention provides compositions and methods for recombinational cloning. The compositions include vectors having multiple recombination sites with unique specificity. The methods permit the simultaneous cloning of two or more different nucleic acid molecules. In some embodiments the molecules are fused together while in other embodiments the molecules are inserted into distinct sites in a vector. The invention also generally provides for linking or joining through recombination a number of molecules and/or compounds (e.g., chemical compounds, drugs, proteins or peptides, lipids, nucleic acids, carbohydrates, etc.) which may be the same or different. Such molecules and/or compounds or combinations of such molecules and/or compounds can also be bound through recombination to various structures or supports according to the invention.

SYSTEMS AND METHODS FOR SUSTAINABLE AQUACULTURE - Provided herein are systems and methods for sustainable aquaculture. The methods provided herein allows recovery and/or recycling of autochthonous nutrients in fish farming, and recovery of allochthonous nutrients present in eutrophic water. The systems provided herein comprises two closely spaced cages, an array of rotary panels that regulates the flow of matters between the two cages; and a means for producing a directional water current.

2012-07-19

20120184002

CULTURING A MICROORGANISM IN A MEDIUM WITH AN ELEVATED LEVEL OF A CARBOXYLATE COUNTERION SOURCE - The invention provides a method of culturing a microorganism that produces a free fatty acid in a culture medium, comprising culturing the microorganism in the culture medium comprising a sufficient amount (e.g., at least about 0.5 mM) of a carboxylate counterion source to enhance viability of the microorganism in the culture medium. Fatty acids produced using the methods of the invention can be used to synthesize a variety of products, including biofuels.

METHODS AND COMPOSITIONS FOR THE PRODUCTION OF FATTY ACIDS IN PHOTOSYNTHETIC PROKARYOTIC MICROORGANISMS - Provided herein are methods and compositions for the production of renewable fatty acids from photosynthetic prokaryotic microorganisms, such as a blue green algae, any specie of the phylum Cyanophyta, a chloroplast of a green algae and/or a Cyanobacterium. Engineered or natural strains of these organisms or organelles can be used to produce both saturated and unsaturated fatty acids with variable chain length specificity from 8-18 carbons. The fatty acids can then be secreted into the culture medium, allowing for rapid, continuous and efficient separation of fatty acid product without harvesting of cell mass.

Reductase Enzymes - In some embodiments, the present invention relates to isolated enzymes useful in reducing a fatty acyl-CoA to a corresponding fatty alcohol in a single biosynthetic step, polynucleotides encoding the enzymes, and methods for making and using these polynucleotides and enzymes. In some embodiments, the invention provides for isolated or recombinant enzymes capable of reducing a fatty acyl-CoA to a fatty alcohol. In still another embodiment, the invention provides for isolated or recombinant polynucleotides encoding an enzyme capable of reducing a fatty acyl-CoA to a fatty alcohol. In other embodiments, the invention provides for methods of making or using enzymes capable of reducing fatty acyl-CoA to a fatty alcohol, and methods of making using polynucleotides that encode the enzymes.

Filamentous fungi and methods for producing trichodiene from lignocellulosic feedstocks - The present invention relates to the production of a C-15 fuel from lignocellulosic or other feedstock. Specifically at least double mutant of filamentous fungi having the isoprenoid pathway results in production of trichodiene in commercial quantities. One embodiment of the invention relates to producing the fuel at the site of the lignocellulosic feedstock to reduce costs of shipping the feedstock.

Emulsion Compositions - An emulsion is useful in allowing a wide variety of gene products to be expressed via eukaryotic in vitro expression. The emulsion comprises a silicone based surfactant, a hydrophobic phase and a hydrophilic phase; wherein the hydrophilic phase comprises a plurality of compartments containing a functional in vitro eukaryotic expression system.

Inhibitors of BMX non-receptor tyrosine kinase - Described herein are irreversible kinase inhibitor compounds, methods for synthesizing such irreversible inhibitors, and methods for using such irreversible inhibitors in the treatment of diseases. Further described herein are methods, assays and systems for determining an appropriate irreversible inhibitor of a protein, including a kinase.

2012-07-19

20120184014

Photoactive Metal Nitrosyls for Blood Pressure Regulation and Cancer Therapy - Disclosed are nitric oxide delivery agents and methods of their use, more specifically to photoactive compounds, which are able to perform targeted delivery of nitric oxide in vitro and in vivo and are useful for medicinal applications including, but not limited, to blood pressure regulation and cancer treatment.

2012-07-19

20120184015

CYTOCHROME P450 OXYGENASES - Nucleic acids encoding cytochrome P450 variants are provided. The cytochrome P450 variants of have a higher alkane-oxidation capability, alkene-oxidation capability, and/or a higher organic-solvent resistance than the corresponding wild-type or parent cytochrome P450 enzyme. A preferred wild-type cytochrome P450 is cytochrome P450 BM-3. Preferred cytochrome P450 variants include those having an improved capability to hydroxylate alkanes and epoxidate alkenes comprising less than 8 carbons, and have amino acid substitutions corresponding to V78A, H236Q, and E252G of cytochrome P450 BM-3. Preferred cytochrome P450 variants also include those having an improved hydroxylation activity in solutions comprising co-solvents such as DMSO and THF, and have amino acid substitutions corresponding to T235A, R471A, E494K, and S1024E of cytochrome P450 BM-3.

2012-07-19

20120184016

NOVEL PROTEIN AND GENE THAT CODES THEREFOR - The present invention provides a novel protein having neuraminidase activity and/or β-galactoside-α2,6-sialyltransferase activity and a nucleic acid encoding the protein. The present invention further provides a vector containing a nucleic acid encoding the protein, a host cell transformed with the vector, together with a method for producing a recombinant β-galactoside-α2,6-sialyltransferase. The present invention also provides an antibody specifically recognizing the protein.

2012-07-19

20120184017

MUTANT DNA POLYMERASES AND USES THEROF - The present invention relates to mutant DNA polymerases which incorporate dideoxynucleotides with about the same efficiency as deoxynucleotides. The present invention also related to mutant DNA polymerases which also have substantially reduced 5′-to-3′ exonuclease activity or 3′-to-5′ exonuclease activity. The invention also relates to DNA molecules coding for the mutant DNA polymerases, and hosts containing the DNA molecules.

STABLE PLASMID EXPRESSION VECTOR FOR BACTERIA - The invention provides compositions and methods for stable plasmid maintenance and protein expression in bacteria. Further provided are compositions and methods for promoting competence in bacteria that are otherwise not transformable.

Convenient System and Method of Composting - The present invention describes a system and method for convenient composting. The system is comprised of a door within a building that opens to the outdoors. Additionally, the system comprises a chute proximal to the door, or affixed to a portion of the door wherein the chute can transport compostable materials to a compost bin. The method disclosed in the present invention comprises the steps of composting including using a door to transport material from indoors to outdoors, placing the material on a chute, wherein the material is transported from an indoor location to a compost bin.

2012-07-19

20120184023

Method of Preparing A Glycoside Of A Mono- Or Diacylglycerol Product From A Plant Material - The present invention provides a method of preparing a glycoside of a mono- or diacylglycerol product from a plant material. The method comprises the steps of: (i) optionally milling the plant material, (ii) extracting the optionally milled plant material with a first aqueous extraction solution obtaining a first liquid phase and a first solid phase, (iii) separating the liquid phase from the solid phase to obtain a glycoside of mono- or diacylglycerol product, (iv) extracting the solid phase from step (iii) with a second extraction solution obtaining a second liquid phase and a second phase, and (v) separating the second liquid phase from the second solid phase to obtain a second and a third glycoside of mono- or diacylglycerol product, wherein the second extraction solution further comprises a cell wall degrading enzyme or a mixture of cell wall degrading enzymes.

2012-07-19

20120184024

Container and Supporting Structure for Housing an Organ - An apparatus intended for evaluation, preservation and perfusion of an organ, such as a lung. The apparatus includes a container with a bottom portion, an insert portion and a lid portion. A pulmonary artery tube is intended to be connected to the lung pulmonary artery and a trachea tube is intended to be connected to the trachea of the lungs and bent tube connects the pulmonary artery tube to a circuit for providing a fluid to the pulmonary artery is provided. The circuit includes a pump, an oxygenator, an optional leukocyte-filter, and a holder for connecting the trachea tube to a source of respiration. There is an oxygenator tube set and a leukocyte-filter tube set. A supporting structure for the container comprises a recess sized for enclosing said container and a display panel. Moreover, there are two handles, which may be unfolded into a position for supporting a sterile cloth.

2012-07-19

20120184025

NUCLEIC ACID ANALYZER - A nucleic acid analyzer includes a nucleic acid purification kit yielding a nucleic acid solution by isolating and purifying nucleic acid from a specimen; a nucleic acid analysis chip having a rotation axis positioned at a center thereof, with reaction containers at an outer portion than the rotation axis, and feeding the acid to the containers through centrifugal force; a specimen-introducing part on which the kit is placed; an analysis chip holder at the specimen-introducing part and supporting the chip; a purification treatment unit injecting the nucleic acid solution containing the nucleic acid into the chip; a centrifugal liquid feed unit feeding the nucleic acid solution to the containers by rotating the chip about the rotation axis; an analysis unit analyzing reaction products in the containers; and a transport part transporting the specimen-introducing part to the purification treatment unit, the centrifugal liquid feed unit, and the analysis unit.

2012-07-19

20120184026

INTEGRATED PROCESSING PLANTS - An integrated plant comprising: (a) one or more lignocellulose processing units producing one or more sugar streams and one or more lignin streams; (b) one or more lignin-processing units processing one or more of said lignin streams into a lignin product; and (c) one or more sugar processing units processing one or more of said sugar streams into a sugar product; (d) at least one transfer mechanism transferring one or more of said sugar stream(s) to one or more of said sugar processing units over a distance of 5 km or less; and (e) at least one transfer mechanism transferring said lignin stream from one or more of said lignocellulose processing units to one or more of said lignin processing units over a distance of 5 km or less.

2012-07-19

20120184027

POLYMER COMPOSITION FOR PHOTOBIOREACTORS - A polymer composition having a modified absorption and transmission characteristic particularly suited for photoreactors or photobioreactors made of plastic molded parts and exposed to sunlight or suitable artificial light sources, the polymer selectively comprises the following substances or a combination thereof in addition to the conventional standard additives: an inorganic or organic near infrared absorber for absorbing long-wavelength radiation, an inorganic or organic reflector for reflecting ultraviolet radiation, an inorganic or organic reflector for reflecting visible, near infrared, or infrared radiation, an optical brightener or fluorescent dye for converting the absorbed ultraviolet radiation into visible light or fluorescent light, a photochromic dye for modifying the transmission characteristic of the plastic molded part as a function of light intensity, and an antimicrobial additive for preventing or reducing organic deposits in the photobioreactor. The photobioreactor has a helically designed inner surface for efficiently mixing the reaction medium.

2012-07-19

20120184028

Micro IVF chamber - A micro IVF chamber that enables rapid filling, hermetic sealing, and custom gas environment control for secure cell extraction, fertilization, culturing, insemination, macro and microscopic content examination, post examination rapid refilling, return to optimal gas levels and pH values, with direct view of cell in conventional microscopes while maintaining culture environment, designed for use in any incubator and multiple devices per shelf for optimum efficiency while maintaining integrity of individual devices and patient-culture identity in a simple one-sample clamp-and-go device is disclosed.

METHODS FOR ESTABLISHING SYMBIOSES - The present invention relates to methods for establishing a symbiosis, including the following steps: selecting an organism or an organelle to constitute the symbiont and an organism to constitute the host, the latter not existing naturally in a symbiotic relationship; contacting the symbiont and the host; and maintaining the combination of the symbiont and the host.

2012-07-19

20120184031

ANTISENSE INHIBITION VIA RNASE H-INDEPENDENT REDUCTION IN MRNA - The present invention provides compositions and methods for reducing levels of a preselected mRNA, using antisense compounds targeted to a splice site or a region up to 50 nucleobases upstream of an exon/intron junction on said mRNA. Preferably, said antisense compounds do not elicit RNAse H cleavage of the mRNA.

Specimen Preservation Chamber and Method - The present invention comprises a specimen preserver. A bubble reservoir is used to hold a preserving liquid such as artificial cerebrospinal liquid (aCSF). Oxygen is introduced into the aCSF by a gas diffuser which is attached to the bubble reservoir. The tissue samples are contained in one or more chambers in a holding platform. The platform is suspended well above the bottom of the bubble reservoir. The lower portion of each of the chambers is open toward the bottom of the bubble reservoir, but is covered by a fine mesh. The gas introduced into the aCSF circulates within the bubble reservoir. However, the tissue samples are not directly exposed to the gas bubbles because the fine mesh excludes the bubbles from the chambers in which the tissue samples are housed.

2012-07-19

20120184035

Methods and Compositions For Reprogramming Cells - Methods and compositions are provided for reprogramming cells. In an exemplary embodiment, fibroblasts are reprogrammed to adopt a skeletal, cardiac, or smooth muscle cell fate. Cell and tissue therapies using said methods and compositions are also disclosed.

2012-07-19

20120184036

Method Of Calculating A Phosphorus-Protein Ratio - A method of identifying a patient who is non-compliant with prescribed diet and/or phosphate binder regimen calculates a phosphorus-protein ratio (PPR) by calculating the patient's protein intake, measuring the patient's serum phosphorus concentration, and estimating the amount of phosphorus removed by the patient's kidneys from measured residual urea clearance. The PPR is the ratio between the total amount of phosphorus removed from the patient and the patient's protein intake. The method enables identifying a patient that is non-compliant with prescribed diet and/or phosphate binder regimen if the PPR is outside of an acceptable range.

2012-07-19

20120184037

Assay Preparation Plates, Fluid Assay Preparation and Analysis Systems, and Methods for Preparing and Analyzing Assays - A fluid assay preparation and analysis system is provided which includes a pipette disposed above an assay plate receiving area, a magnet disposed below the assay plate receiving area in approximate alignment with the pipette, and an actuator configured to move the magnet proximate the assay plate receiving area. A method for preparing and analyzing an assay includes injecting a sample into a sample well of an assay preparation plate and inserting the assay preparation plate into a fluid assay analysis system. The method further includes mixing the sample with one or more reagents in an assay plate receiving area of the system and subsequently aspirating the prepared assay into an examination chamber of the system.

2012-07-19

20120184038

TAGGING SYSTEM AND METHOD - A method of tracing an aqueous liquid, particularly an aqueous urea used for addition to a selective catalytic reduction system to remove NOx from diesel exhaust, includes adding a tracer comprising a pre-determined amount of a phenol to the liquid. The liquid can subsequently be identified by reacting a sample with a reagent containing a predetermined amount of 4-aminoantipyrine in the presence of an initiating compound such that the reaction between the reagent and a phenol in the liquid produces a chromophore and measuring the absorbance of the resulting solution of the chromophore.

2012-07-19

20120184039

METHOD AND SYSTEM FOR ANALYZING CONCENTRATIONS OF DIVERSE MERCURY SPECIES PRESENT IN A FLUID MEDIUM - A method for facilitating removal of mercury from a primary fluid stream of interest which is contaminated with organically-bound, elemental, and ionic mercury species. The stream is analyzed to establish the relative content of the organically-bound, elemental, and ionic mercury species present therein by forming a diverted side stream from the primary stream, and passing the side stream successively through three in series filter stages, the first captures organically bound mercury, the second captures elemental mercury, and the third captures ionic mercury. The side stream flow through the filter stages is continued for a predetermined period, and upon conclusion of the period the quantity of mercury collected at each of the filtration stages is determined. This data is then utilized to determine the capacity of the three different filtration stages required to reduce the mercury content in the mam stream to a desired level.

2012-07-19

20120184040

METHOD AND DEVICE FOR DETECTION OF HEAVY METAL IONS IN WATER - This disclosure discloses a method and a device for the detection of heavy metal ions in water. The method includes: providing a detection material, wherein the detection material includes a hydrophilic layer which is at least partially covered by a hydrophobic layer formed from a long-chain compound selected from the group consisting of a long-chain thiol, a long-chain fatty acid and combinations thereof, and wherein a detection area is an area covered by the hydrophobic layer, and the detection area has a surface having an initial contact angle with water of more than or equal to about 120°; contacting the detection area with an aqueous solution sample; determining whether the surface of the detection area has a hydrophobicity-hydrophilicity change after contact with the aqueous solution sample; and deciding whether heavy metal ions exist in the aqueous solution sample according to the determination.

2012-07-19

20120184041

Apparatus and Method for Detecting and/or Quantifying Compounds of Interest Present in Gaseous Form or Dissolved In A Solvent - The invention relates to an apparatus and method for detecting and/or quantifying compounds of interest present in gaseous form or dissolved in a solvent. The apparatus according to the invention includes an electrical device including two electrodes, and a device for measuring the variation in charges between the two electrodes of the electrical device. The electrical device includes a layer made of an insulating dielectric material onto which a layer of receptor molecules is grafted, and finally, a layer of semiconductor material is deposited onto the receptor molecule layer. The invention can be used in the field of detecting and/or quantifying compounds of interest present, in particular, in a gas or in a solution.

2012-07-19

20120184042

Electron Transfer Dissociation for Biopolymer Sequence Analysis - The present invention relates to a new method for fragmenting ions in a mass spectrometer through the use of electron transfer dissociation, and for performing sequence analysis of peptides and proteins by mass spectrometry. In the case of peptides, the invention promotes fragmentation along the peptide backbone and makes it possible to deduce the amino acid sequence of the sample, including modified amino acid residues, through the use of an RF field device.

2012-07-19

20120184043

FLAT BODY IN THE MANNER OF A CHIP CARD FOR BIOCHEMICAL ANALYSIS AND METHOD FOR THE USE THEREOF - At least two microfluidic devices and at least one sensor chip are formed in a flat body. The at least one sensor chip is in direct contact with at least one first microfluidic device. A second microfluidic device in the manner of a pipette is integral with the flat body or connected thereto. The flat body may be used by docking an E-cup by way of a clamping device of the flat body to the flat body and exchanging fluid between the E-cup and the flat body by way of the second microfluidic device.

2012-07-19

20120184044

MOLECULARLY-IMPRINTED POLYMERIC MATERIALS FOR VISUAL DETECTION OF EXPLOSIVES - A molecularly-imprinted polymeric material that selectively binds with an explosive compound. The molecularly-imprinted polymeric material comprises a cross-linked, water-soluble polymer having basic functional groups and a binding site capable of selectively binding an explosive compound. The basic functional groups have a pKa that is sufficiently high to react with the explosive compound to result in a visually detectable color change. For example, the basic functional groups may have a pKa in the range of 6.0-9.0. The molecularly-imprinted polymeric material may be used in a variety of applications, such as a projectile for detecting explosives. Also described is a method for making a molecularly-imprinted polymeric material.

2012-07-19

20120184045

SENSING ELEMENT FOR NITROGEN OXIDE MOLECULE SENSING APPARATUS FOR NITROGEN OXIDE MOLECULE AND METHOD FOR SENSING NITROGEN OXIDE MOLECULE - In a sensing element for a nitrogen oxide molecule of the present invention, a sensing portion that is to be bonded to a nitrogen oxide molecule to be sensed is fixed between paired metal electrodes through connecting portions. The sensing portion is a single porphyrin molecule or a single porphyrin derivative molecule each having, as a central metal thereof, iron or cobalt. The connecting portions are each a mercaptophenyleneethynyl group bonded to the single porphyrin molecule or the single porphyrin derivative molecule. Provided are a sensing element for nitrogen oxide molecule, a sensing apparatus for nitrogen oxide molecule, and a method for sensing nitrogen oxide molecule.

2012-07-19

20120184046

SELECTIVE BOND REDUCTION IN MICROFLUIDIC DEVICES - The invention overcomes the limitations described for the bonding of structured layers by providing a method for selectively reducing the bonding of materials. In its most generic form, the invention uses a bonding technique in combination with a printing method for modifying or covering at least one portion of a surface to either fully or partially prevent localised bonding. The structuring process may act upon the layers either before or after the bonding of the layers. The invention overcomes the limitations described in the application of affinity chromatography by providing a planar substrate with discrete optical detection flow cells that contain porous material and have connecting microchannels for fluid delivery and/or removal, and a method for making the same.

2012-07-19

20120184047

NANOPLASMONIC DEVICE - The present invention relates to a solution for nanoplasmonic measurement using a nanoplasmonic device with a short range order structure of trough going channels in contact with a fluid flow cell. The device is manufactured in a micro machine process comprising steps of using combined colloidal lithography, thin film deposition and etching steps on the micro/nano scale, for chemical or bio analytical sensing, and other uses. The solution makes use of shifts in the nanoplasmonic resonance, an optical property of the device that is sensitive to changes in refractive index induced by molecular reactions or other processes.

2012-07-19

20120184048

METHOD FOR CHARACTERIZATION OF BIOLOGICAL BONDS - The invention relates to the field of intensity measurements of a light scattering label bound to a surface of a support using an optical evanescent field. According to the invention, the method comprises the steps: a) Providing an assay comprising at least one light scattering label bound to a surface of a support by at least one bond; b) Measuring the fluctuations in the intensity of scattered light of the label in an optical evanescent field over time while the label is bound to the surface. The method according to the invention allows to identify different bonds and/or to distinguish between different bonds.

2012-07-19

20120184049

METHODS, IMMUNOASSAYS AND DEVICES FOR DETECTION OF ANTI-LIPOIDAL ANTIBODIES - Compositions, methods and devices for the detection of anti-lipoidal antibodies and the diagnosis of disease, for example, syphilis, are described. In particular, a method for immobilizing a lipoidal antigen, comprising cardiolipin, lecithin, and cholesterol, on a solid support (such as a nitrocellulose membrane) is described. The ability to immobilize a lipoidal antigen on a membrane satisfies a long-felt need for a membrane-based assay for the detection of anti-lipoidal antibodies. Also described are immunoassay devices for concurrently performing treponemal and non-treponemal tests for syphilis.

DEVICE AND METHOD FOR DETECTING AT LEAST ONE SUBSTANCE - A device for detecting at least one substance may include a resonator which, on its surface facing away from the carrier, is provided with a chemically sensitive layer for selectively binding a substance that is to be detected. An acoustic mirror is arranged between the carrier and the resonator. The acoustic mirror constitutes a band elimination filter having two closely adjacent notch frequencies, as a result of which the device is capable of oscillating in two resonant frequencies. The mass binding of the substance and the temperature can be determined computationally from the measured resonant frequencies.

2012-07-19

20120184052

Isolation and Analysis of Thiol Protein Matter Using Gold Nano-Particles - A method of rapidly and accurately identifying and analyzing thiol proteins in a sample using gold nanoparticles. Disclosed are embodiments of a flow device for isolation, fractionation and subsequent instrumental analysis of thiol containing proteins from various samples or tissue sources using gold nanoparticles. Also disclosed are embodiments of a flow device for detecting, isolating and fractionating S-nitrosated proteins and peptides for subsequent analysis, including identification of S-nitrosation sites.

2012-07-19

20120184053

METHOD OF MANUFACTURING A MAGNETIC READ SENSOR HAVING A LOW RESISTANCE CAP STRUCTURE - A method for manufacturing a magnetic sensor that decreases area resistance and decreases MR ratio of the sensor by eliminating any oxide formation in the capping layer of the sensor. The method includes forming a sensor stack having a multi-layer capping structure formed there-over. The multi-layer capping structure can include first, second, third and fourth layers. The second layer is constructed of a material that is not easily oxidized and which is different from the first layer. The sensor can be formed using a mask that includes a carbon hard mask. After the sensor stack has been formed by ion milling, the hard mask can be removed by reactive ion etching. Then, a cleaning process is performed to remove the second, third and fourth layers of the capping layer structure using an end point detection method such as secondary ion mass spectrometry to detect the presence of the second layer.

2012-07-19

20120184054

MANUFACTURING APPARATUS AND METHOD FOR SEMICONDUCTOR DEVICE - Provided is a semiconductor manufacturing apparatus including: a reaction chamber including a gas supply inlet and a gas exhaust outlet, and into which a wafer is to be introduced; a process gas supply mechanism that supplies process gas into the reaction chamber from the gas supply inlet of the reaction chamber; a wafer retaining member that is arranged in the reaction chamber and that retains the wafer; a heater that heats the wafer retained by the wafer retaining member to a predetermined temperature; a rotation drive control mechanism that rotates the wafer retaining member together with the wafer; a gas exhaustion mechanism that exhausts gas in the reaction chamber from the gas exhaust outlet of the reaction chamber; and a drain that is disposed at a bottom portion near a wall surface in the reaction chamber and that collects and discharges oily silane that drips from the wall surface.

2012-07-19

20120184055

Making Method of Sample for Evaluation of Laser Irradiation Position and Making Apparatus Thereof and Evaluation Method of Stability of Laser Irradiation Position and Evaluation Apparatus Thereof - A method for making a sample for evaluation of laser irradiation position and evaluating the sample, and an apparatus which is switchable between a first mode of modification of semiconductor and a second mode of making and evaluating the sample. Specifically, a sample is made by irradiating a semiconductor substrate for evaluation with a pulse laser beam while the semiconductor substrate is moved for evaluation at an evaluation speed higher than a modifying treatment speed, each relative positional information between pulse-irradiated regions in the sample is extracted, and stability of the each relative positional information between pulse-irradiated regions is evaluated. The evaluation speed is such a speed that separates the pulse-irradiated regions on the sample from each other in a moving direction.

2012-07-19

20120184056

METHOD AND APPARATUS FOR MANUFACTURING WHITE LIGHT-EMITTING DEVICE - Methods and apparatus for manufacturing a semiconductor light-emitting device that emits white light by forming a phosphor layer on an emission surface of the semiconductor light-emitting device at a wafer-level. The method includes: forming a plurality of light-emitting devices on a wafer; thinning the wafer, on which the plurality of light-emitting devices are formed; disposing the thinned wafer on a carrier film; and forming a phosphor layer on an emission surface of the plurality of light-emitting devices on the wafer.

2012-07-19

20120184057

III-NITRIDE SEMICONDUCTOR LASER DEVICE, AND METHOD OF FABRICATING THE III-NITRIDE SEMICONDUCTOR LASER DEVICE - A method of fabricating a III-nitride semiconductor laser device includes: preparing a substrate with a semipolar primary surface, where the semipolar primary surface includes a hexagonal III-nitride semiconductor; forming a substrate product having a laser structure, an anode electrode, and a cathode electrode, where the laser structure includes a substrate and a semiconductor region, and the semiconductor region is formed on the semipolar primary surface; after forming the substrate product, forming first and second end faces; and forming first and second dielectric multilayer films for an optical cavity of the nitride semiconductor laser device on the first and second end faces, respectively.

2012-07-19

20120184058

LlQUID CRYSTAL DISPLAY AND METHOD FOR MANUFACTURING THE SAME - The present invention provides a thin film transistor having high performance in a liquid crystal display, and a manufacturing method of a liquid crystal display according to an exemplary embodiment of the present invention that includes: forming a gate line including a gate electrode on a substrate; forming a gate insulating layer on the gate line; forming a data line including a source electrode and a drain electrode facing the source electrode on the gate insulating layer; forming a partition defining a pixel area and having an opening region exposing the gate insulating layer on the gate electrode, the source electrode and the drain electrode on the gate line, and the data line and the drain electrode; forming a semiconductor in the opening region; forming a color filter in the pixel area defined by the partition; and forming a pixel electrode connected to the drain electrode on the color filter.

2012-07-19

20120184059

METHOD FOR MANUFACTURING LIGHT EMITTING DEVICE - A light emitting device includes a substrate and a plurality of pixel rows. The pixel rows are arranged on the substrate. Each of the pixel rows includes a first sub-pixel row having a plurality of first sub-pixels, a second sub-pixel row having a plurality of second sub-pixels, and a third sub-pixel row having a plurality of third sub-pixels. In the m

METHOD FOR MANUFACTURING SOLAR CELL - A method for manufacturing a solar cell includes forming an impurity doped region of a second conductive type at a substrate of a first conductive type, sequentially irradiating laser shots onto the impurity doped region of the substrate to form an emitter part including a first emitter region having a first sheet resistance and a second emitter region having a second sheet resistance less than the first sheet resistance, and forming a plurality of first electrodes connected to the second emitter region and forming a second electrode connected to the substrate.

2012-07-19

20120184064

METHOD OF MANUFACTURING PHOTOELECTRIC CONVERSION DEVICE - A fragile layer is formed in a region at a depth of less than 1000 nm from one surface of a single crystal semiconductor substrate, and a first impurity semiconductor layer and a first electrode are formed at the one surface side. After bonding the first electrode and a supporting substrate, the single crystal semiconductor substrate is separated using the fragile layer or the vicinity as a separation plane, thereby forming a first single crystal semiconductor layer over the supporting substrate. An amorphous semiconductor layer is formed on the first single crystal semiconductor layer, and a second single crystal semiconductor layer is formed by heat treatment for solid phase growth of the amorphous semiconductor layer. A second impurity semiconductor layer having a conductivity type opposite to that of the first impurity semiconductor layer and a second electrode are formed over the second single crystal semiconductor layer.

2012-07-19

20120184065

METHOD FOR PRODUCING GRAPHENE OXIDE WITH TUNABLE GAP - A method of fabricating a graphene oxide material in which oxidation is confined within the graphene layer and that possesses a desired band gap is provided. The method allows specific band gap values to be developed. Additionally, the use of masks is consistent with the method, so intricate configurations can be achieved. The resulting graphene oxide material is thus completely customizable and can be adapted to a plethora of useful engineering applications.

2012-07-19

20120184066

SINTERED In-Ga-Zn-O-TYPE OXIDE - An oxide sintered body including In (indium element), Ga (gallium element) and Zn (zinc element), having a total content of In, Ga and Zn relative to total elements except for an oxygen element of 95 at % or more, and including a compound having a bixbyite structure represented by In

2012-07-19

20120184067

Releasing and post-releasing processes in fabrications for micromirror array devices - A releasing and post-releasing method for making a micromirror device and a micromirror array device are disclosed herein. The releasing method removes the sacrificial materials in the micromirror and micromirror array so as to enabling movements of the movable elements in the micromirror and micromirror array device. The post-releasing method is applied to improve the performance and quality of the released micromirrors and micromirror array devices.

2012-07-19

20120184068

METHOD OF MANUFACTURING SEMICONDUCTOR DEVICE - A method includes the steps of: (a) fixing a front surface of a wafer (semiconductor wafer) having the front surface, a plurality of chip regions formed on the front surface, a dicing region formed between the chip regions, and a rear surface opposite to the front surface to the supporting member; (b) in a state of having the wafer fixed to the supporting member, grinding the rear surface of the wafer to expose the rear surface; (c) in a state of having the wafer fixed to the supporting member, dividing the wafer into the chip regions; (d) etching side surfaces of the chip regions to remove crushed layers formed in the step (c) on the side surfaces and obtain a plurality of semiconductor chips. After the steps (e) and (d), the plurality of divided chip regions are peeled off from the supporting member to obtain a plurality of semiconductor chips.

2012-07-19

20120184069

METHOD FOR BONDING OF CHIPS ON WAFERS - Method for bonding of a plurality of chips onto a base wafer which contains chips on the front, the chips being stacked in at least one layer on the back of the base wafer and electrically conductive connections are established between the vertically adjacent chips, with the following steps: a) fixing of the front of the base wafer on a carrier, b) placing at least one layer of chips in defined positions on the back of the base wafer, and c) heat treatment of the chips on the base wafer fixed on the carrier, characterized in that prior to step c) at least partial separation of the chips of the base wafer into separated chip stack sections of the base after takes place.

2012-07-19

20120184070

METHOD FOR FORMING CHIP PACKAGE - An embodiment of the invention provides a method for forming a chip package which includes: providing a substrate having a first surface and a second surface, wherein at least two conducting pads are disposed on the first surface of the substrate; partially removing the substrate from the second surface of the substrate to form at least two holes extending towards the first surface, wherein the holes correspondingly and respectively align with one of the conducting pads; after the holes are formed, partially removing the substrate from the second substrate to form at least a recess extending towards the first surface, wherein the recess overlaps with the holes; forming an insulating layer on a sidewall and a bottom of the trench and on sidewalls of the holes; and forming a conducting layer on the insulating layer, wherein the conducting layer electrically contacts with one of the conducting pads.

2012-07-19

20120184071

SURFACE COATING METHOD, SEMICONDUCTOR DEVICE, AND CIRCUIT BOARD PACKAGE - To provide a surface coating method, which contains applying a surface coating material to a layered structure so as to cover at least a surface of an insulating film of the layered structure, to form a coating on the surface of the insulating film, wherein the surface coating material contains a water-soluble resin, an organic solvent, and water, and wherein the layered structure contains the insulating film exposed to an outer surface, and a patterned metal wiring exposed to an outer surface.

2012-07-19

20120184072

METHODS FOR MANUFACTURING SUPERJUNCTION SEMICONDUCTOR DEVICE HAVING A DIELECTRIC TERMINATION - A superjunction semiconductor device is provided having at least one column of a first conductivity type and at least one column of a second conductivity type extending from a first main surface of a semiconductor substrate toward a second main surface of the semiconductor substrate opposed to the first main surface. The at least one column of the second conductivity type has a first sidewall surface proximate the at least one column of the first conductivity type and a second sidewall surface opposed to the first sidewall surface. A termination structure is proximate the second sidewall surface of the at least one column of the second conductivity type. The termination structure includes a layer of dielectric of an effective thickness and consumes about 0% of the surface area of the first main surface. Methods for manufacturing superjunction semiconductor devices and for preventing surface breakdown are also provided.

2012-07-19

20120184073

PROGRAMMABLE HIGH-K/METAL GATE MEMORY DEVICE - A method of fabricating a memory device is provided that may begin with forming a layered gate stack atop a semiconductor substrate and patterning a metal electrode layer stopping on the high-k gate dielectric layer of the layered gate stack to provide a first metal gate electrode and a second metal gate electrode on the semiconductor substrate. In a next process sequence, at least one spacer is formed on the first metal gate electrode atop a portion of the high-k gate dielectric layer, wherein a remaining portion of the high-k gate dielectric is exposed. The remaining portion of the high-k gate dielectric layer is etched to provide a first high-k gate dielectric having a portion that extends beyond a sidewall of the first metal gate electrode and a second high-k gate dielectric having an edge that is aligned to a sidewall of the second metal gate electrode.

2012-07-19

20120184074

METHOD OF MANUFACTURING THIN FILM TRANSISTOR - A thin film transistor for an organic light emitting diode includes a substrate including a pixel portion and an interconnection portion, a buffer layer on the substrate, a gate electrode and a gate interconnection on the buffer layer, wherein the gate electrode is located at the pixel portion and the gate interconnection is located at the interconnection portion, a gate insulating layer on the substrate, a semiconductor layer on the gate electrode, source and drain electrodes electrically connected to the semiconductor layer, and a metal pattern on the gate interconnection.

2012-07-19

20120184075

REDUCING DISLOCATION FORMATION IN SEMICONDUCTOR DEVICES THROUGH TARGETED CARBON IMPLANTATION - A method of forming a semiconductor device includes implanting an amorphizing species into a crystalline semiconductor substrate, the substrate having a transistor gate structure formed thereupon. Carbon is implanted into amorphized regions of the substrate, with specific implant conditions tailored such that the peak concentration of carbon species coincides with the end of the stacking faults, where the stacking faults are created during the recrystallization anneal. The implanted carbon pins partial dislocations so as to prevent the dislocations from disassociating from the end of the stacking faults and moving to a region in the substrate directly below the transistor gate structure. This removes the defects, which cause device leakage fail.

2012-07-19

20120184076

FLASH MEMORY STRUCTURE WITH ENHANCED CAPACITIVE COUPLING COEFFICIENT RATIO (CCCR) AND METHOD FOR FABRICATION THEREOF - A flash memory structure having an enhanced capacitive coupling coefficient ratio (CCCR) may be fabricated in a self-aligned manner while using a semiconductor substrate that has an active region that is recessed within an aperture with respect to an isolation region that surrounds the active region. The flash memory structure includes a floating gate that does not rise above the isolation region, and that preferably consists of a single layer that has a U shape. The U shape facilitates the enhanced capacitive coupling coefficient ratio.

METHOD FOR MANUFACTURING SEMICONDUCTOR MEMORY DEVICE - According to one embodiment, a method for manufacturing a semiconductor memory device, includes forming a stacked body on a substrate by alternately stacking a first insulating film and a second insulating film, making a through-hole extending in a stacking direction of the first insulating film and the second insulating film to pierce the stacked body, forming at least a portion of a blocking insulating film, a charge trap film, and a tunneling dielectric film of a MONOS on an inner surface of the through-hole, forming a channel semiconductor on the tunneling dielectric film, making a trench in the stacked body, removing the second insulating film by performing etching via the trench, and filling a conductive material into a space made by the removing of the second insulating film.

2012-07-19

20120184079

METHODS OF MANUFACTURING A SEMICONDUCTOR DEVICE - A semiconductor device can include a first gate electrode including a gate insulating pattern, a gate conductive pattern and a capping pattern that are sequentially stacked on a semiconductor substrate, and a first spacer of a low dielectric constant disposed on a lower sidewall of the first gate electrode. A second spacer of a high dielectric constant, that is greater than the low dielectric constant, is disposed on an upper sidewall of the first gate electrode above the first spacer.

2012-07-19

20120184080

COMPACT THERMALLY CONTROLLED THIN FILM RESISTORS UTILIZING SUBSTRATE CONTACTS AND METHODS OF MANUFACTURE - A method of forming a semiconductor structure includes forming a resistor on an insulator layer over a substrate, and forming at least one dielectric layer over the resistor. The method also includes forming a substrate contact through the at least one dielectric layer, through the resistor, through the insulator layer, and into the substrate. The substrate contact comprises a high thermal conductivity material.

2012-07-19

20120184081

PROCESS FOR SINGLE AND MULTIPLE LEVEL METAL-INSULATOR-METAL INTEGRATION WITH A SINGLE MASK - A method of fabricating a MIM capacitor is provided. The method includes providing a substrate including a dielectric layer formed on a first conductive layer and a second conductive layer formed over the dielectric layer, and patterning a mask on the second conductive layer. Exposed portions of the second conductive layer are removed to form an upper plate of a MIM capacitor having edges substantially aligned with respective edges of the mask. The upper plate is undercut so that edges of the upper plate are located under the mask. Exposed portions of the dielectric layer and the first conductive layer are removed using the mask to form a capacitor dielectric layer and a lower plate of the MIM capacitor having edges substantially aligned with respective edges of the mask.