Colts: The NFL’s biggest surprise with rookie quarterback Andrew Luck and interim coach Bruce Arians, the Colts start a stretch of five out of seven on the road. A win keeps them in the No. 4 AFC playoff spot.

Jaguars: The Jaguars are trying to avoid their first 1-8 start and first 0-5 home start in franchise history. A win would break a five-game skid and take them out of the NFL cellar they share with Kansas City.

Freeney was injured when the teams met in Week 3, but has two sacks in six games this season. Last week against Miami, he had one sack and two quarterback hits against Jake Long. In 11 career games against the Jaguars, Freeney has 10 sacks. Monroe has been the Jaguars’ best offensive linemen this year, but has one penalty in each of the last two games, giving him a team-high four this year.

The Colts lead 15-8 (7-4 at Jacksonville), but the Jaguars are 4-1 in the teams’ last five games, including a 22-17 win in Week 3 at Indianapolis when Blaine Gabbert threw an 80-yard touchdown pass to Cecil Shorts with 45 seconds remaining.