240.13d-102 Schedule 13G - Information to be included in statements filed

pursuant to 240.13d-1(b), (c), and (d) and amendments thereto

filed pursuant to 240.13d-2.

Securities and Exchange Commission, Washington, D.C. 20549

Schedule 13G

Under the Securities Exchange Act of 1934

(Amendment No. 1)*

(Name of Issuer)

Karyopharm Therapeutics Inc.

(Title of Class of Securities)

Common Stock, Par Value $0.0001 Per Share

(CUSIP Number)

48576U106

(Date of Event Which Requires Filing of this Statement)

December 31, 2017

Check the appropriate box to designate the rule pursuant to which this

Schedule is filed:

[ ] Rule 13d-1(b)

[ x ] Rule 13d-1(c)

[ ] Rule 13d-1(d)

*The remainder of this cover page shall be filled out for a reporting person'sinitial filing on this form with respect to the subject class of securities, andfor any subsequent amendment containing information which would alter thedisclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not bedeemed to be “filed” for the purpose of Section 18 of the Securities ExchangeAct of 1934 (“Act”) or otherwise subject to the liabilities of that section of theAct but shall be subject to all other provisions of the Act (however, seethe Notes).

This Amendment No. 1 (this “Amendment”) amends and restates that Schedule 13G filed under this Issuer by the reporting persons identified herein with respect to Common Stock of the Issuer on November 6, 2017 (the “Initial Filing”). As reflected in this Amendment, Point72 Asset Management, L.P. (the “Former Investment Manager”) merged with and into Stamford Harbor Capital, L.P. (the “Stamford Harbor”), a Delaware limited partnership, on January 1, 2018 (the “Merger”), at which time Stamford Harbor, as the surviving entity, was renamed Point72 Asset Management, L.P. (“Point72 Asset Management”). In connection with the Merger, the investment management agreements between the Former Investment Manager and certain funds it managed were assigned pursuant to the Merger to Point72 Asset Management. As a result, Point72 Asset Management may be deemed to beneficially own the securities of the Issuer underlying such interests, as described in this Amendment.

Filing Agreement, a copy of which is filed with this Schedule 13G as Exhibit99.1, pursuant to which they have agreed to file this Schedule 13G jointly in accordance with the provisions of Rule 13d-1(k) of the Act.

(iv) Shared power to dispose or to direct the disposition of: 3,351,996

2. Point72 Capital Advisors, Inc.

(a) Amount beneficially owned: 3,351,996

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(b) Percent of class: 7.1%

(c) Number of shares as to which the person has:

(i) Sole power to vote or to direct the vote: 0

(ii) Shared power to vote or to direct the vote: 3,351,996

(iii) Sole power to dispose or to direct the disposition of: 0

(iv) Shared power to dispose or to direct the disposition of: 3,351,996

3. Cubist Systematic Strategies, LLC

(a) Amount beneficially owned: 963

(b) Percent of class: <0.1%

(c) Number of shares as to which the person has:

(i) Sole power to vote or to direct the vote: 0

(ii) Shared power to vote or to direct the vote: 963

(iii) Sole power to dispose or to direct the disposition of: 0

(iv) Shared power to dispose or to direct the disposition of: 963

4. Point72 Asia (Hong Kong) Limited

(a) Amount beneficially owned: 334

(b) Percent of class: <0.1%

(c) Number of shares as to which the person has:

(i) Sole power to vote or to direct the vote: 0

(ii) Shared power to vote or to direct the vote: 334

(iii) Sole power to dispose or to direct the disposition of: 0

(iv) Shared power to dispose or to direct the disposition of: 334

5. Steven A. Cohen

(a) Amount beneficially owned: 3,353,293

(b) Percent of class: 7.1%

(c) Number of shares as to which the person has:

(i) Sole power to vote or to direct the vote: 0

(ii) Shared power to vote or to direct the vote: 3,353,293

(iii) Sole power to dispose or to direct the disposition of: 0

(iv) Shared power to dispose or to direct the disposition of: 3,353,293

Point72 Asset Management, Point72 Capital Advisors Inc., Cubist SystematicStrategies, Point72 Asia (Hong Kong), and Mr. Cohen own directly no Shares.Pursuant to an investment management agreement, Point72 Asset Managementmaintains investment and voting power with respect to the securities held bycertain investment funds it manages. Point72 Capital Advisors Inc. is thegeneral partner of Point72 Asset Management. Pursuant to an investmentmanagement agreement, Cubist Systematic Strategies maintains investment andvoting power with respect to the securities held by certain investment fundsit manages. Pursuant to an investment management agreement, Point72 Asia (HongKong) maintains investment and voting power with respect to the securities held by certain investment funds it manages. Mr. Cohen controls each of

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Point72 Asset Management, Point72 Capital Advisors Inc., Cubist SystematicStrategies, and Point72 Asia (Hong Kong). As of December 31, 2017, by
reason of the provisions of Rule 13d-3 of the Securities Exchange Act of 1934,
as amended, each of (i) Point72 Asset Management, Point72 Capital Advisors
Inc., and Mr. Cohen may be deemed to beneficially own 3,351,996 Shares
(constituting approximately 7.1% of the Shares outstanding); (ii) Cubist
Systematic Strategies and Mr. Cohen may be deemed to beneficially own
963 Shares (constituting <0.1% of the Shares outstanding); and (iii) Point72
Asia (Hong Kong) and Mr. Cohen may be deemed to beneficially own 334
Shares (constituting <0.1% of the Shares outstanding). Each of Point72 Asset
Management, Point72 Capital Advisors Inc., CubistSystematic Strategies, Point72 Asia (Hong Kong), and Mr. Cohen disclaims beneficial ownership of any of the securities covered by this statement.

Item 5.Ownership of 5 Percent or Less of a Class.

If this statement is being filed to report the fact that as of the date hereof

the reporting person has ceased to be the beneficial owner of more than

5 percent of the class of securities, check the following [].

Instruction. Dissolution of a group requires a response to this item.

Item 6. Ownership of More than 5 Percent on Behalf of Another Person.

Not applicable

Item 7. Identification and Classification of the Subsidiary Which Acquired

the Security Being Reporting on by the Parent Holding Company or Control

Person.

Not applicable

Item 8. Identification and Classification of Members of the Group

Not applicable

Item 9. Notice of Dissolution of Group.

Not applicable

Item 10. Certifications

By signing below I certify that, to the best of his/her knowledge and belief,

the securities referred to above were not acquired and are not held for the purpose

of or with the effect of changing or influencing the control of the issuer of

the securities and were not acquired and are not held in connection with or

as a participant in any transaction having that purpose or effect.

Signature. After reasonable inquiry and to the best of my knowledge and belief,

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I certify that the information set forth in this statement is true, complete

and correct.

Dated: February 14, 2018

POINT72 ASSET MANAGEMENT, L.P.

By: /s/ Jason M. Colombo

Name: Jason M. Colombo

Title: Authorized Person

POINT72 CAPITAL ADVISORS, INC.

By: /s/ Jason M. Colombo

Name: Jason M. Colombo

Title: Authorized Person

CUBIST SYSTEMATIC STRATEGIES, LLC

By: /s/ Jason M. Colombo

Name: Jason M. Colombo

Title: Authorized Person

POINT72 ASIA (HONG KONG) LIMITED

By: /s/ Jason M. Colombo

Name: Jason M. Colombo

Title: Authorized Person

STEVEN A. COHEN

By: /s/ Jason M. Colombo

Name: Jason M. Colombo

Title: Authorized Person

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Exhibit 99.1

JOINT FILING AGREEMENT

The undersigned hereby agree that the foregoing statement on Schedule 13G is filed on behalf of each of the undersigned in accordance with the provisions of Rule 13d-1(k) under the Securities Exchange Act of 1934, as amended, and that all subsequent amendments to this statement on Schedule 13G may be filed on behalf of each of the undersigned without the necessity of filing additional joint filing agreements.