Conorenal Syndrome or Mainzer-Saldino Syndrome is a group of diseases involving kidney, skeletal system and eye. In few cases, cerebral ataxia has been documented. The skeletal effect indicates cone shape epiphysis of extremity bones. Kidney effects are observed in childhood and eventually results in kidney failure. Retinal pigmentosa results in blindness. The medical condition is a genetic pathological condition which usually affects following organs-

In this article, we will discuss about various symptoms, the genes involved and treatments rendered for Conorenal Syndrome/Mainzer-Saldino Syndrome.

What Is Conorenal Syndrome Or Mainzer-Saldino Syndrome?

Kidney Disease1-

History of chronic kidney disease.

Kidney disease often starts during childhood.

Kidney disease progressively gets worse. The rate with which the renal dysfunction deteriorates is quite variable and differs from person to person, but ultimately the affected individual ends up with renal failure.

Eye Involvement2-

Conorenal syndrome affects retinal tissue of both the eyes.

The disease causes degeneration of photosensitive tissue of the retina.

The intensity and extend of degeneration is variable. Some of the affected people get blind and/or have very poor vision since infancy.

Skeletal Abnormalities-

The skeletal abnormality seen with Conorenal Syndrome or Mainzer-Saldino Syndrome is one in which the ends of the bone become cone shaped in the fingers.

The abnormalities are easily identified on x-ray images within the first year of life.

Bone abnormalities are often observed in multiple bones.

The growth of the extremity bone is restricted and skeletal abnormalities result in short stature.

Conorenal Syndrome or Mainzer-Saldino syndrome resulting in short stature is also known as craniosynostosis when shape of the skull and head is abnormal.