True-SEEPAGE is a non-subtraction non-contrast based
segmented imaging technique which can be used to study renal perfusion and
function while avoiding the problem of Nephrogenic Systemic Fibrosis that may
be associated with Gd-based contrast agents. In True-SEEPAGE, the stationary
tissue is saturated and the unsaturated spins from inflowing are imaged, giving
rise to a true perfusion signal in the kidney. Observed perfusion is seen as a
function of renal arterial blood flow. This technique may, in the future, be
used to detect and characterize tumors in the kidney without the administration
of contrast agents.