Eyepi'illos are enemies that appear in Mario & Luigi: Dream Team. In the field, Eyepi'illos sit still on the ground, as if it was deactivated. When Mario and Luigi approach, it activates, signalled by a pinkish light forming in the Eyepi'illo. It then rises into high altitude, and chases Mario and Luigi, charging up and firing a laser beam at them while doing so.

In battle, Eyepi'illos can float up into the sky and descend before a Bro., who it starts rapidly spinning before, with its inside lighting up with a pinkish tint as it charges up a laser beam. The Bro. it is spinning before must hammer the Eyepi'illo before it fires the laser at him, and must whack it when it's not facing either Mario or Luigi, as the Eyepi'illo fires the energy ball in the direction it was facing when hit, this hitting anything in its path, friend or foe.

The Eyepi'illo may also float near the Bro. it plans to attack, charge up, and fire a barrage of laser blasts at the approached Bro., who must jump to avoid it. If successful in avoiding the lasers, the Eyepi'illo will then down float down to ground level and charge at the same Bro., who must jump on or over the Eyepi'illo to avoid it.

When it is low on HP, it will go 'round the two Bros. and show flame. When it dodged the hammers, they explode and are KO'd. The only way to attack is to time hammers properly.