Following her Fox years, Blaine returned to the stage, making her Broadway debut in the Frank Loesser musical Guys and Dolls in 1950. Her character Adelaide has been engaged to inveterate gambler Nathan Detroit for 14 years, a condition which, according to her song “Adelaide’s Lament“, can foster physical illness as well as chronic heartbreak. After the show’s 1200-performance run on Broadway, in which she starred opposite Sam Levene as Nathan Detroit and Robert Alda as fellow gambler Sky Masterson, she reprised the role in London‘s West End in 1953, and then on film in 1955, with Frank Sinatra playing Nathan and Marlon Brando in Sky’s role.

Blaine in her later years was managed by Rob Cipriano and L’Etoile Talent Agencies in New York City. Cipriano spent the early 1980s developing projects for Blaine including Puppy Love a TV sitcom with Jake LaMotta and Pat Cooper. She always shared in meeting that working with Cipriano reminded her working with her first husband Manny Franks.

Blaine’s first marriage, to Franks, lasted from 1945 to 1956. She then married Milton Rackmil, president of Universal Studios and Decca Records, in 1959, and recorded several albums prior to their 1961 divorce. In 1973, Blaine married Stuart Clark. In 1983 she became the first celebrity to make public service announcements for AIDS-related causes. She made numerous appearances in support of the then fledgling AIDS-Project Los Angeles (APLA) and in 1983 recorded her cabaret act for AEI Records which donated its royalties to the new group; this included the last recordings of her songs from Guys and Dolls.