Some prescription and over-the-counter medications, as well as supplements and other substances, can raise your blood pressure. These substances also can interfere with medications intended to lower your blood pressure.

Here are some medications, supplements and other substances that can increase your blood pressure. If you're using any of these substances and are worried about the effect it could have on your blood pressure, talk to your doctor.

Acetaminophen

People who take acetaminophen (Tylenol, others) daily are more likely to develop high blood pressure than are those who don't take acetaminophen. There's no evidence that occasional use of acetaminophen causes any long-term increase in blood pressure.

Tell your doctor if you take acetaminophen regularly. Your doctor might recommend alternating between acetaminophen and other pain relievers. Because pain relievers affect blood pressure in different ways, alternating between them may give your body a break. Also consider other ways to control pain, such as warm or cold compresses, exercise or massage.

Have your blood pressure checked regularly. Talk to your doctor about which pain medication is best for you. If you must continue taking a pain medication that increases your blood pressure, your doctor may recommend lifestyle changes or additional medication to control your blood pressure.

Antidepressants

Antidepressants work by changing your body's response to brain chemicals, including serotonin, norepinephrine and dopamine, that affect your mood. These chemicals may also cause your blood pressure to increase. Examples of antidepressants that can raise your blood pressure include:

Venlafaxine (Effexor)

Bupropion (Wellbutrin)

Desipramine (Norpramin)

If you take antidepressants, have your blood pressure checked regularly. If your blood pressure increases or isn't well controlled, ask your doctor about alternatives to these medications. Your doctor may recommend lifestyle changes or additional medications to control your high blood pressure.

Hormonal birth control

Birth control pills and other hormonal birth control devices contain hormones that may increase your blood pressure by narrowing smaller blood vessels. Virtually all birth control pills, patches and vaginal rings come with warnings that high blood pressure may be a side effect. The risk of high blood pressure is greater if you're older than age 35, overweight or a smoker.

Not all women will have increased blood pressure from using hormonal birth control, but if you're worried, have your blood pressure checked at least every six to 12 months. If you already have high blood pressure, consider using a different form of birth control. While nearly all birth control pills can raise your blood pressure, your blood pressure may be less likely to increase if you use a birth control pill or device that contains a lower dose of estrogen.

Caffeine

The role caffeine plays in blood pressure is still debatable. Consuming 200 to 300 milligrams of caffeine can temporarily cause a spike in your blood pressure, but it's unclear whether the effect is temporary or long lasting.

Some studies suggest that coffee may contain a substance that lowers blood pressure, thus counteracting any effects from caffeine. In addition, the caffeine content of coffee can vary widely, so it's difficult to say how many cups of coffee you can drink a day.

To see if caffeine raises your blood pressure, check your pressure within 30 minutes of drinking a cup of coffee or another caffeinated beverage you regularly drink. If your blood pressure increases by five to 10 points, you may be sensitive to the blood pressure raising effects of caffeine.

Mesas AE, et al. The effect of coffee on blood pressure and cardiovascular disease in hypertensive individuals: A systematic review and meta-analysis. The American Journal of Clinical Nutrition. 2011;94:1113.

Steffen M, et al. The effect of coffee consumption on blood pressure and the development of hypertension: A systematic review and meta-analysis. Journal of Hypertension. 2012;30:2245.

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