Store the antibody undiluted at 2-8°C.Shelf life: one year from despatch.

Format

Purification:

Ammonium sulfate + DEAE-cellulose, gradient elution

Buffer System:

PBS

Preservatives:

0,09% sodium azide

State:

Lyophilized purified Ig fractionPurified

Reconstitution:

Reconstitute with 1 ml sterile water.

Species Reactivity

Species reactivity (tested):

Human.

Specificity

Specificity:

This antibody recognizes the intact platelet GPIIb/IIIa complex (alphaIIb/beta3), i.e. it does not bind to dissociated GPIIb or GPIIIa. The antibody reacts with human platelets and megakaryocytes. Apparent molecular weight under reducing conditions: GPIIIa; 110 kD; GPIIb alpha chain; 125 kD, beta chain; 25 kD. The antibody does not bind to platelets from patients with Glanzmann thrombasthenia and does not recognize the vitronectin receptor, which contains GPIIIa as a beta subunit (cf. CD61). VM16a inhibits platelet Fc-receptor dependent reactions due to the proposed topographical association of the platelet Fc-receptor and the glycoprotein IIb-IIIa complex.