Learning objectives:
• Aberrant immunity during the perinatal period is critical for increased risk of developing ASD
• Brain inflammation can develop when the gut-blood and blood-brain-barrier are disrupted
• Neurotensin and mitochondrial components participate in brain inflammation
• Serum neurotensin and mitochondrial DNA may serve as objective markers for ASD
• The flavonone luteolin inhibits Neuroinflammation and is neuroprotective
• The luteolin-containing supplements NeuroProtek and BrainGain have significant benefit in ASD