Is it possible to make a Giant Bomb chat app?

When watching Live Quick Looks, I usually like to have the video on my desktop fullscreen and the chat on my iPad. At the moment, I do this by using the 'popout chat' in the browser but this is not ideal. A dedicated app for displaying live chat would be an interesting thing to devleop.

Is this at all possible with API access? Is this content that is accessable?

Chat is implemented using WebSocket. There are Java and Objective-C WebSocket libraries available, so mobile apps should be possible if you're willing to deal with login. I'll be looking into this more in the future.