Overexpression of HER-2 (neu, erbB-2) results in cellular transformation and is associated with a variety of human cancers.
The HER-2 oncogene encodes a 185-kDa transmembrane receptor tyrosine kinase. Its expression is regulated at the translational level.
There are two distinct translational mechanisms controling erbB-2 protein expression: the first is a cell type-dependent mechanism that causes increased erbB-2 translation while the second is a cell type-independent repression of downstream ......

::Features

Feature Key

uORF

::References

ID

[1]

Authors

Stephanie J. Child, Melanie K. Miller, and Adam P. Geballe

Title

Translational control by an upstream open reading frame in the HER-2/neu transcript