Abstract

Retrospective analysis of 'routine' chromosome preparations from 2 patients with Fanconi anemia and 2 others with ataxiateleangiectasia showed increased chromosome breakage and a tendency to premature centromere division (PCD) with special reference to early separation of the large acrocentric (13-15) chromosomes. The findings suggest that PCD may be a manifestation of chromosome instability related to potential malignancy.

abstract = "Retrospective analysis of 'routine' chromosome preparations from 2 patients with Fanconi anemia and 2 others with ataxiateleangiectasia showed increased chromosome breakage and a tendency to premature centromere division (PCD) with special reference to early separation of the large acrocentric (13-15) chromosomes. The findings suggest that PCD may be a manifestation of chromosome instability related to potential malignancy.",

author = "K. Mehes and Buhler, {E. M.}",

year = "1995",

month = mar

day = "13",

doi = "10.1002/ajmg.1320560117",

language = "English",

volume = "56",

pages = "76--79",

journal = "American Journal of Medical Genetics, Part A",

issn = "1552-4825",

publisher = "Wiley-Liss Inc.",

number = "1",

}

TY - JOUR

T1 - Premature centromere division

T2 - A possible manifestation of chromosome instability

AU - Mehes, K.

AU - Buhler, E. M.

PY - 1995/3/13

Y1 - 1995/3/13

N2 - Retrospective analysis of 'routine' chromosome preparations from 2 patients with Fanconi anemia and 2 others with ataxiateleangiectasia showed increased chromosome breakage and a tendency to premature centromere division (PCD) with special reference to early separation of the large acrocentric (13-15) chromosomes. The findings suggest that PCD may be a manifestation of chromosome instability related to potential malignancy.

AB - Retrospective analysis of 'routine' chromosome preparations from 2 patients with Fanconi anemia and 2 others with ataxiateleangiectasia showed increased chromosome breakage and a tendency to premature centromere division (PCD) with special reference to early separation of the large acrocentric (13-15) chromosomes. The findings suggest that PCD may be a manifestation of chromosome instability related to potential malignancy.