Doramectin is a new generation of antiparasitic , compared with other commercially available ivermectin products, anti-parasite range of Doramectin is broader, with better effect, and Doramectin can prevent parasite reinfection for a longer valid time, It is the world's best, the most potential anti-parasitic drugs for development veterinary .
Doramectin as a pesticide can kill all the the internal and external parasites , and is also valid to nematodes, arthropods. At present, Chinese pig industry commonly used insecticide drugs include: parasite drugs: albendazole, levamisole, trichlorfon, Vietnam, hygromycin, ivermectin, avermectin. External parasite drugs: trichlorfon, amitraz, diazinon, permethrin drugs, avermectin, ivermectin.
Doramectin has a good effect on pig gastrointestinal nematodes , it is reported that pig is injected 0.3 mg/kg by intramuscular, dosing artificial and natural infection cases after 7 days , 14 days, 21 days, weight gains is significantly higher (swine P <0.0001); compared with the control group, percentage of getting rid of worms is 100%, and there are no side effects.
In Pig scabies mite treatment, from piglets to sows ,Doramectin has good results .After artificial infection scabies mites, according to the body weight ,administrated 0.3 mg/kg intramuscularly, four weeks after the test, the result of inflammation of the skin injury in pigs and worms Elimination of infected body, is very significant (P <0.05). Treatment for pregnant sows kidney worm, press the 0.3 mg/kg dose neck single injection, the 56 day and 57 day of testing, the detection rate of Urine eggs is 0, the percentage of getting rid of them is 100%, while the control group per milliliter of urine displays 3762 eggs. For lung worms, lice and other pigs parasites,it has the same effect.
According to more than l ng/g tissue concentration of the drug having anti-parasitic activity, the drug can be used to assess the validity.
Duration time of Ivermectin is greater than 1 ng/g concentration :18 days for the skin, the lungs 18 days, 18 days for gastrointestinal mucosa, gastric mucosa wrinkled 18 days.
Duration time of Doramectin is greater than 1 ng/g concentration: 26 days for the skin, the lungs 38 days, 38 days for gastrointestinal mucosa, gastric mucosa wrinkled 38 days.
Thus,duration time of more than 1 ng/g doramectin in the gastrointestinal mucosa, lung tissue is 38 days, 20 days more than ivermectin.
So the effect of doramectin to drive and to kill the parasites is stronger than ivermectin, and it can be effective to prevent the parasite reinfection .
The above information is edited by the Chemicalbook of Tian Ye.

[Chemical properties] brown powder , very low solubility in water.
Doramectin is used for the treatment of livestock diseases such as nematodes and mites ectoparasitosis,it is fermented by recombinant avermitilis (Streptomyces avermitilis) new strain, and the main difference from ivermectin is that C25 is substituted by cyclohexyl. It is a new, broad-spectrum antiparasitic drug,and is efficient for gastrointestinal nematodes, lung nematodes, Euglena, lice, ticks, mites and wound maggots , also has a good effect on internal and external parasites especially certain nematodes (round worms) and arthropods , but invalid to tapeworms, flukes and protozoa . Its mechanism of action is to increase the release of the inhibitory neurotransmitter γ-aminobutyric acid (GABA) of the worm, thereby blocking the transmission of nerve signals, so that muscle cells lose their ability to contract, resulting in death of the parasites. the neurotransmitter of Peripheral nerves of mammals is acetylcholine,and will not be affected by Doramectin, doramectin cannot go through the blood-brain barrier easily , minimal damage to the central nervous system,safe to cattle. The main feature is that the plasma concentration and half-life are higher or twice than Ivermectin. The United States has approved to use as cattle, pigs and dedicated injection and cattle dedicated pour.

1, doramectin is unstable and decomposes rapidly in the sunlight to be inactivated, its remnants of drugs are toxic to fish and aquatic organisms, so pay attention to water protection.
2, pour-on: bovine application, not rain within 6 hours.
3, use with caution in dogs.
4, the goods will be placed out of reach of children, the operator should not eat or smoking, wash hands after handling.
5, withdrawal period, 35 days of cattle, pigs 24 days.

Chemical Properties

White Solid

Uses

antibacterial

Uses

Doramectin is a biosynthetic avermectin derived from a mutant strain of Streptomyces avermitilis, supplemented with a cyclohexylcaboxylic acid starting unit. Doramectin was developed as an anthelmintic for internal parasite control. The presence of the cyclohexyl group replacing the sec-butyl moiety affords greater hydrophobicity and longer biological half-life compared to avermectin. Like the other milbemycin/avermectins, it selectively binds to parasite glutamate-gated chloride ion channels and disrupts neurotransmission leading to paralysis and death of the parasite.