Browse our MYBL2 Proteins (MYBL2)

On www.antibodies-online.com are 6 V-Myb Myeloblastosis Viral Oncogene Homolog (Avian)-Like 2 (MYBL2) Proteins from 3 different suppliers available. Additionally we are shipping MYBL2 Antibodies (103) and MYBL2 Kits (8) and many more products for this protein. A total of 128 MYBL2 products are currently listed.

Results coupled with functional studies demonstrate that B-MYB not only controls and accelerates cell cycle progression in ESCs (show NR2E3 Proteins) it contributes to fate decisions and maintenance of pluripotent stem cell identity.

Our data suggest that B-Myb is required as a pioneer factor to enable FoxM1 (show FOXM1 Proteins) binding to G2/M gene promoters and explains how these transcription factors may collaborate to induce mitosis.

Mybl2 upregulation induces fast growth and progression of premalignant and malignant liver, through cell cycle deregulation and activation of genes and pathways related to tumor progression.

The transcription factor B-Myb is maintained in an inhibited state in target cells through its interaction with the nuclear corepressors N-CoR and SMRT.

Results describe the characterization of a corepressor site (downstream repression site (DRS (show SRPX Proteins))) required for transcriptional regulation of the B-myb (MybL2 gene) promoter.

B-Myb repressor function is regulated by cyclin A phosph (show CCNA2 Proteins)orylation and sequences within the C-terminal domain.

We found that B-Myb upregulated expression of the key epithelial-to-mesenchymal transition regulator snail (show SNAI1 Proteins) and that it mediated epithelial-to-mesenchymal transition activation and cell invasion by B-Myb.

conclude that downregulation of MYBL2 activity below levels predicted by classical haploinsufficiency underlies the clonal expansion of hematopoietic progenitors in a large fraction of human myeloid malignancies

Suggest B-myb had critical roles in both cell cycle progression and tumorigenesis in breast cancer.

B-Myb plays a role in suppression of keratinocyte differentiation and maintenance of the undifferentiated proliferative phenotype by modulating the expression levels of cell cycle regulatory proteins, expressed in the S and G2/M phases of the cell cycle

Results show that E7 interacts with the B-Myb, FoxM1 (show FOXM1 Proteins) and LIN9 (show LIN9 Proteins) components of this activator complex, leading to cooperative transcriptional activation of mitotic genes in primary cells and E7 recruitment to the corresponding promoters.

MYBL2 expression analysis could be useful to define subgroups of patients with poor prognosis.

MYBL2 Protein Profile

Protein Summary

The protein encoded by this gene, a member of the MYB family of transcription factor genes, is a nuclear protein involved in cell cycle progression. The encoded protein is phosphorylated by cyclin A/cyclin-dependent kinase 2 during the S-phase of the cell cycle and possesses both activator and repressor activities. It has been shown to activate the cell division cycle 2, cyclin D1, and insulin-like growth factor-binding protein 5 genes. Transcript variants may exist for this gene, but their full-length natures have not been determined.