Depression in Type 2 Diabetes

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ClinicalTrials.gov Identifier: NCT01327404

Recruitment Status : Unknown

Verified March 2011 by University of Illinois at Chicago. Recruitment status was: Recruiting

The purpose of the study is to examine the relationship between brain structure and depression in adults aged 30 or older with Diabetes. This relationship is determined using magnetic resonance imaging technology (MRI), a scanner with a magnet that is used to create images of the brain.

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Ages Eligible for Study:

30 Years to 80 Years (Adult, Senior)

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Yes

Sampling Method:

Probability Sample

Study Population

Patients of all subject types will be recruited through the general medical, psychiatric, and endocrinology clinics associated with the UIC Medical Center. Patients will be first cleared for participation in the study by their primary physicians. The patient and family will be approached by the PI or another investigator who will explain the research and its goals. We also plan to recruit subjects through flyers and advertisements.

Criteria

Inclusion Criteria:

Age: 30 to 80 years old

Diagnosis of type 2 diabetes

Diagnosis of major depressive disorder using standard diagnostic and statistical manual (DSM) criteria

Score of 15 or greater on the 17-item Hamilton Depression rating scale

Mini Mental Status Exam score of 24 or greater

No evidence of clinical dementia or any other clinical brain disorder

Free of psychotropic/psychoactive medications for at least 2 weeks

First episode of depression diagnosed either after or around the time type 2 diabetes was diagnosed since we are interested in the relationship between the cerebrovascular effect of diabetes and the pathophysiology of major depression

Exclusion Criteria:

Presence of dementia or any other clinical brain disorder (Parkinson's, Alzheimer's)