In addition to Star Trek, Scharf has guest-starred on over twenty other television series. In 1966, she appeared on both The Man from U.N.C.L.E. and The Girl from U.N.C.L.E.; on the latter, she was directed by Jud Taylor. She then worked on an episode of Daniel Boone along with Jeffrey Hunter, who starred in Star Trek's first pilot, "The Cage".

Scharf portrayed China Hazard, the daughter of Nehemiah Persoff's Major Hazard, in the 1968 episode of The Wild Wild West entitled "The Night of the Underground Terror". Jeff Corey also guest-starred in this episode as a colonel serving under Persoff's character. That same year, Scharf appeared in an episode of The Danny Thomas Hour, along with Robert Brown and Ricardo Montalban.

Sharf has since retired from acting to enter politics. She was once a state senator in California. As of 2007, she was a real estate developer working in Los Angeles. She has been married to Emmy Award-winning writer Bob Schiller (The Flip Wilson Show, All in the Family) since 29 March 1969; they have had two children together.