14
8.7 Mutations Some gene mutations do not affect phenotype. –A mutation may be silent. –A mutation may occur in a noncoding region. –A mutation may not affect protein folding or the active site. blockage no blockage Ex: Cystic Fibrosis- caused by a deletion

15
8.7 Mutations Mutations in body cells do not affect offspring. Mutations in sex cells can be harmful or beneficial to offspring. Natural selection often removes mutant alleles from a population

16
8.7 Mutations Beneficial mutations CCR5 32 is a deletion thought to resist the bubonic and pneumonic plague as well as HIV Mutations that cause resistance to antibiotics

17
8.7 Mutations Chang and Eng Bunker Born in 1811 Married sisters Had 21 children between them In modern times, they could have easily been separated Died on the same day in 1874 Chang contracted Pneumonia and died in his sleep- Eng refused to be separated from his dead twin and died several hours later. Conjoined Twins