TORONTO — Will Middlebrooks hit three home runs, two off NL Cy Young Award winner R.A. Dickey, and the Boston Red Sox routed the Toronto Blue Jays 13-0 Sunday.

Middlebrooks went 4 for 5 with four RBIs. He hit a two-run shot to right in the first inning and a solo drive into the second deck in left in the fifth off Dickey. He connected again off Dave Bush with a leadoff longball to left in the seventh, the first three homer game of his career.

Mike Napoli added a two-run shot, and Jacoby Ellsbury and Daniel Nava also went deep as the Red Sox connected for six homers.

The Yankees (2-4) avoided a sweep and dropping to their worst six-game record since starting the 1989 season 1-7.

Sabathia (1-1) gave up four hits and three walks while striking out four in 114 pitches, bouncing back from a dreadful opening-day start.

Verlander (1-1) allowed three runs on seven hits and three walks.

TWINS 4, ORIOLES 3

BALTIMORE — Aaron Hicks ended an 0-for-13 skid with a tiebreaking RBI single in a two-run seventh inning, rallying the Twins past the Orioles.

J.J. Hardy homered for the Orioles, who dropped the final two games of the weekend set. It was their first series loss to the Twins since July 2010.

Trailing 3-2, the Twins started their comeback when Jason Hammel (1-1) plunked Trevor Plouffe on the left elbow leading off the seventh.

Anthony Swarzak (1-0), activated from the disabled list before the game after missing time with broken ribs, pitched 1 1-3 innings of scoreless relief.

Glen Perkins pitched the ninth for his second save.

INDIANS 13, RAYS 0

ST. PETERSBURG, Fla. — Mark Reynolds and Lonnie Chisenhall hit three-run homers off AL Cy Young Award winner David Price, Justin Masterson pitched seven strong inning and the Indians hammered the Rays. Reynolds homered twice. Carlos Santana had a career-high five hits, including a home run off Fernando Rodney and a pair of doubles. Michael Bourn also homered for the Indians.

Price (0-1) gave up eight runs, 10 hits and three walks in five innings. He had been 5-0 with a 1.64 ERA in six career starts against Cleveland.

Masterson (2-0) allowed two hits against a team that’s often tagged him. He was 1-7 with a 7.74 ERA in his previous 13 games against Tampa Bay.

ATHLETICS 9, ASTROS 3

HOUSTON — Brett Anderson struck out 10 more Houston batters and the Athletics backed him with three home runs for win and a three-game sweep of the Astros.

Coco Crisp homered for the third straight day, Jed Lowrie again connected against his former team and Chris Young homered in his hometown. The A’s sent Houston to its fifth straight loss.

Anderson (1-1) and the A’s bullpen combined for 14 strikeouts. The Astros’ 74 strikeouts through the first six games are the most in major league history since 1921, STATS said.

CHICAGO — Dayan Viciedo hit a solo home run with one out in the 10th inning Sunday, lifting the Chicago White Sox over the Mariners 4-3.

Viciedo hit the first game-ending homer of his career, connecting against Kameron Loe (1-1).

Alex Rios homered in his career-best third straight game and Adam Dunn also homered for Chicago.

Addison Reed (1-0) pitched a scoreless 10th.

CARDINALS 14, GIANTS 3

SAN FRANCISCO — Matt Cain became the first Giants pitcher to allow nine runs in an inning since 1902 when Matt Carpenter and the St. Louis Cardinals tagged him Sunday in a 14-3 romp over San Francisco.

The Cardinals chased Cain (0-1) while scoring nine times in the fourth inning. The last two runs came home on Carlos Beltran’s single off reliever Jose Mijares.

According to research by the Elias Sports Bureau provided by the team, Cain was the first Giants pitcher to give up so many runs in a single inning since John Cronin on Sept. 27, 1902, in the second game of New York’s doubleheader against Brooklyn.

Adam Wainwright (1-1) pitched seven innings, giving up two runs on seven hits for his first win since signing a rich new contract at the end of spring training.

BRAVES 5, CUBS 1

ATLANTA — Tim Hudson pitched six-plus strong innings and added an RBI and Ramiro Pena hit a two-run single to help the Braves beat the Cubs.

The three-game sweep ended a 5-1 homestand for Atlanta, which got a solo homer from Dan Uggla in the eighth off Hisanori Takahashi.

Hudson (1-0) allowed three hits, one run and two walks in 6 2-3 innings. He struck out seven while improving to 3-1 in seven career starts against the Cubs with a 3.12 ERA.

Jeff Samardzija (1-1) set a career high with 13 strikeouts, but gave up four hits, four runs and four walks in 5 2-3 innings.

METS 4, MARLINS 3

NEW YORK — Marlon Byrd grounded a two-run single just inside third base in the bottom of the ninth inning to give the Mets a victory over the Marlins.

Daniel Murphy homered and Anthony Recker had a run-scoring double for the Mets, who spoiled an impressive major league debut by prized Miami pitching prospect Jose Fernandez.

Justin Ruggiano, Chris Valaika and Donovan Solano (three hits) each had an RBI double off substitute starter Aaron Laffey to give the Marlins an early 3-0 cushion. But closer Steve Cishek (0-1) was unable to hold a one-run lead in the ninth, and Miami dropped to 1-5 heading into its home opener Monday night against Atlanta.

The 20-year-old Fernandez, who had never been above Class A, gave up one run and three hits in five innings. He walked one and struck out eight, a record for a Marlins pitcher in his major league debut.

Scott Rice (1-0) worked a scoreless ninth for his first big league win after 14 seasons in the minors.

DIAMONDBACKS 8, BREWERS 7, 11 INNINGS

MILWAUKEE — Pinch-hitter Eric Hinske belted a long two-run homer in the 11th inning and the Diamondbacks beat the Brewers to complete a three-game series sweep.

With Cliff Pennington aboard following a leadoff double, Hinske drove a 1-2 pitch from John Axford (0-1) onto the concourse beyond the wall in center field. Hinske raised his right arm as he rounded second with his eighth career pinch-hit homer.

Tony Sipp (1-0) struck out two in a perfect 10th inning and Heath Bell held on for his first save after J.J. Putz blew an opportunity in the ninth.

ROCKIES 9, PADRES 1

DENVER — Dexter Fowler hit an early two-run homer and Jhoulys Chacin pitched effectively into the seventh inning, helping the Rockies to their first sweep of the Padres at Coors Field in 10 years.

Wilin Rosario broke open a tight game with a three-run homer in the seventh as the Rockies improved to 5-1, their best start since 1995 when the Blake Street Bombers began 7-1.

Chacin (1-0) turned in another efficient performance as he allowed one run before being pulled with two outs in the seventh.

Edinson Volquez (0-2) settled down after a shaky first inning in which he allowed three runs, including Fowler’s fourth homer of the season. Volquez lasted six innings, giving up four runs and nine hits.

DODGERS 6, PIRATES 2

LOS ANGELES — Hyun-Jin Ryu earned his first major league victory, shrugging off a two-run homer in the first inning by Andrew McCutchen and pitching the Dodgers past the Pirates for a three-game sweep.

Adrian Gonzalez drove in four runs with three hits and Justin Sellers homered for the Dodgers.

Ryu (1-1) allowed two runs and three hits in 6 1-3 innings, striking out six and walking two.

Jeff Locke (0-1) lost in his season debut, giving up four runs and eight hits over six innings.

INTERLEAGUE

ROYALS 9, PHILLIES 8

PHILADELPHIA — Billy Butler hit a grand slam that needed video review for confirmation and tied a Royals franchise record with seven RBIs, and Kansas City held on for a win over the Phillies.

Butler’s fifth-inning homer, the first slam of his career and the first ever allowed by Philadelphia left-hander Cole Hamels, put Kansas City ahead 6-4.

James Shields (1-1), acquired in an offseason trade with Tampa Bay, earned his first victory as a Royal. The right-hander gave up hits to five of the first six batters in a four-run first inning, but settled down to blank the Phillies for the next five innings on five hits while striking out eight and walking none.

Butler came through with the bases loaded again in the sixth, hitting a two-run single off Chad Durbin.