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As with UFC 103 and UFC 104, a portion of the preliminary card aired live and commercial-free during an hour-long block on Spike.[4]Tito Ortiz was originally scheduled to fight Mark Coleman; however, on October 5, 2009, the fight was cancelled as Coleman was suffering from a knee injury. UFC confirmed that Forrest Griffin would step in to face Ortiz.[5]

On October 26, UFC Heavyweight Champion Brock Lesnar pulled out of his fight against Shane Carwin due to an illness that kept him from training.[6] The UFC therefore had the Ortiz v. Griffin fight headline the UFC 106 card.[7]

Dana White confirmed on November 19 that Karo Parisyan had pulled out of his fight against Dustin Hazelett for undisclosed reasons. Hazelett was paid his full purse including show and win.[14] As a result, the fight between Paulo Thiago and Jacob Volkmann was promoted to the main card.[15] Parisyan was also cut from the promotion following this incident.

The following is the reported payout to the fighters as reported to the Nevada State Athletic Commission. It does not include sponsor money or "locker room" bonuses often given by the UFC and also do not include the UFC's traditional "fight night" bonuses.[17]