Despite an international agreement, U.S. health authorities still have not received H7N9 avian flu specimens from their Chinese counterparts.ImageHealth workers attending to an H7N9 avian flu patient in Wuhan, China, in 2017. CreditCreditAgence France-Presse -- Getty ImagesEmily Baumgaertner

By Emily Baumgaertner

Aug. 27, 2018

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For over a year, the Chinese government has withheld lab samples of a rapidly evolving influenza virus from the United States — specimens needed to develop vaccines and treatments, according to federal health officials.

Despite persistent requests from government officials and research institutions, China has not provided samples of the dangerous virus, a type of bird flu called H7N9. In the past, such exchanges have been mostly routine under rules established by the World Health Organization.

Now, as the United States and China spar over trade, some scientists worry that the vital exchange of medical supplies and information could slow, hampering preparedness for the next biological threat.

The scenario is “unlike shortages in aluminum and soybeans,” said Dr. Michael Callahan, an infectious disease specialist at Harvard Medical School.

“Jeopardizing U.S. access to foreign pathogens and therapies to counter them undermines our nation’s ability to protect against infections which can spread globally within days.”

Experts concur that the world’s next global pandemic will likely come from a repeat offender: the flu. The H7N9 virus is one candidate.

Since taking root in China in 2013, the virus has spread through poultry farms, evolving into a highly pathogenic strain that can infect humans. It has killed 40 percent of its victims.

If this strain were to become highly contagious among humans, seasonal flu vaccines would provide little to no protection. Americans have virtually no immunity.

“Pandemic influenza spreads faster than anything else,” said Rick A. Bright, the director of Biomedical Advanced Research and Development Authority, an agency within the Department of Health and Human Services that oversees vaccine development. “There’s nothing to hold it back or slow it down. Every minute counts.”

Under an agreement established by the World Health Organization, participating countries must transfer influenza samples with pandemic potential to designated research centers “in a timely manner.”

That process — involving paperwork, approval through several agencies and a licensed carrier — normally takes several months, according to Dr. Larry Kerr, the director of pandemics and emerging threats at the Department of Health and Human Services.

But more than one year after a devastating wave of H7N9 infections in Asia — 766 cases were reported, almost all in China — the Centers for Disease Control and Prevention is still waiting for several viral samples, the National Security Council and the W.H.O. confirmed.

Scientists at the Department of Agriculture have had such difficulty obtaining flu samples from China that they have stopped requesting them altogether, according to a government official who spoke anonymously because he was not authorized to discuss the matter.

At least four research institutions have relied upon a small group of H7N9 samples from cases in Taiwan and Hong Kong. (All four asked not to be identified for fear of further straining ties.)

The Chinese embassy in Washington did not respond to multiple requests for comment. The Chinese Center For Disease Control and Prevention also did not reply to inquiries regarding the transfer.

When the H7N9 virus first appeared in China, researchers say the Chinese government at first provided timely information. But communication has gradually worsened.

The Office of the United States Trade Representative in April released a proposed list of products to be targeted for tariffs — including pharmaceutical products such as vaccines, medicines and medical devices.

So far, none of those medical products have landed on the final tariff lists. But lower-level trade negotiations with China concluded on Thursday with few signs of progress, increasing the likelihood of additional tariffs.

The United States relies on China not only for H7N9 influenza samples but for medical supplies, such as plastic drip mechanisms for intravenous saline, as well as ingredients for certain oncology and anesthesia drugs. Some of these are delivered through a just-in-time production model; there are no stockpiles, which could prove dangerous if the supply was disrupted, health officials said.

Scientists believe top commerce officials in both governments view the viral samples much like any other laboratory product, and may be unfamiliar with their vital role in global security.

“Countries don’t own their viral samples any more than they own the birds in their skies,” said Andrew C. Weber, who oversaw biological defense programs at the Pentagon during the Obama administration.

“Given that this flu virus is a potential threat to humanity, not sharing it immediately with the global network of W.H.O. laboratories like C.D.C. is scandalous. Many could die needlessly if China denies international access to samples.”

For over a decade, epidemiological data and samples have been used as trade war pawns.

China hid the 2002 outbreak of severe acute respiratory syndrome, or SARS, for four months and then kept the findings of its research private. Some provinces withheld information about cases even from the central government in Beijing.

In 2005, Chinese authorities insisted an H5N1 influenza outbreak was contained, contradicting University of Hong Kong scientists who offered evidence that it was expanding. Those authorities hesitated to share viral samples from infected wild birds with the international community, concealing the scope to avoid a hit to their vast poultry industry.

Indonesia followed suit, refusing in 2007 to share specimens of H5N1 with the United States and United Kingdom, arguing that the countries would use the samples to develop a vaccine that Indonesians could not afford.

Those episodes led to the 2011 development of the W.H.O.’s Pandemic Influenza Preparedness Framework, which aims to promote sample exchanges as well as developing countries’ access to vaccines.

But for countries like China, bearing the burden of a novel virus is paradoxical. Outbreaks are expensive — the wave of H7N9 infections in 2013 alone cost China more than $6 billion, according to the United Nations — but they can provide a head-start in developing valuable treatments.

“In a sense, China has made lemonade from lemons — converting the problem of global infectious disease threats into lifesaving and valuable commodities,” Dr. Callahan said.

And now, as the H7N9 virus evolves, United States authorities worry that the Chinese have obfuscated the scale and features of this outbreak.

The Chinese government has refused to share clinical data from infected patients, according to scientists, and claims to have all but eradicated H7N9 through a single poultry vaccination campaign.

“Influenza is going to do what it does best, which is mutate,” Dr. Kerr said.

And considering that we're talking about a country that will cut organs out of living donors for profit, I wouldn't rule out the possibility that they're readying themselves for a pandemic in which they alone will have access to the most effective (or only) vaccine. Great way to emerge on top after a virus sweeps the globe. Call me cynical, but compassion isn't real high on their list of priorities, even for their own citizens. I don't think our welfare is even on that list.

"Buy it cheap. Stack it deep""Any community that fails to prepare, with the expectation that the federal government will come to the rescue, will be tragically wrong." Michael Leavitt, HHS Secretary.

And considering that we're talking about a country that will cut organs out of living donors for profit, I wouldn't rule out the possibility that they're readying themselves for a pandemic in which they alone will have access to the most effective (or only) vaccine. Great way to emerge on top after a virus sweeps the globe. Call me cynical, but compassion isn't real high on their list of priorities, even for their own citizens. I don't think our welfare is even on that list.

JD, I am 100% with you on this. There is no logical reason for China NOT to share the H7N9 samples, unless they have ulterior motives.

I'm certain we have our spooks on the ground in China, visiting live bird markets and collecting samples/buying birds etc. We'll get our samples by hook or crook, and probably already have a stockpile.

If we would only develop the universal flu vaccine, this nonsense wouldn't matter.

The rumors coming out of China are horrific! 1,000,000 people held in re-education camps! Religious persecution, water boarding, being placed in handcuffs and ankle cuffs for up to 12 hours” or long periods strapped in agony in a metal contraption known as a “tiger chair!” “There were so many things to recite, and if you couldn’t recite them, they wouldn’t allow you to eat, sleep or sit,” he said. “They brainwash you; you must become like a robot. Listen to whatever the party says, listen to the party’s words, follow the party.”

Some inmates committed suicide, Bekali said.

He said the food was poor, with meat infrequent and food poisoning not uncommon. Inmates sometimes were forced to eat pork, forbidden in Islam, as punishment, while Bekali said those accused of being “religious extremists” also were forced to drink alcohol.

In one report, RFA quoted a Chinese official as justifying the widespread detentions in blunt terms.

“You can’t uproot all the weeds hidden among the crops in the field one by one — you need to spray chemicals to kill them all,” the official was quoted as saying. “Reeducating these people is like spraying chemicals on the crops. That is why it is a general reeducation, not limited to a few people.” China's dramatic economic growth over the past few decades has increased demands for natural resources within and beyond the country itself in ways that are unprecedented in human history!For the Party to survive, China needs the same things Germany and Japan needed before WWII and it's not money! They need more space and more natural resources! If you've studied the lead up to WWII, the similarities are undeniable! From their buying of scrape steel, modernizing their military, (China is poised to challenge American air dominance and has already shown itself to be a formidable naval power), and their aggression from the South China Sea to India and Nepal they are trying to exert their ideas and power!

I'm with JD when he says "I wouldn't rule out the possibility that they're readying themselves for a pandemic in which they alone will have access to the most effective (or only) vaccine. Great way to emerge on top after a virus sweeps the globe. Call me cynical, but compassion isn't real high on their list of priorities, even for their own citizens. I don't think our welfare is even on that list."

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