Since the coordination environments of metals in metal-based antibiotics is not well-known and continuing with our studies in order to shed more light on the nature of mono- and polynuclear Schiff base complexes containing antibiotics [ 13 - 18 ], we report here the isolation and characterization of metal(II) complexes containing a Schiff base ligand derived from cefotaxime antibiotic and salicylaldehyde. (hindawi.com)

While Klebsiella strains donated cefotaxime, cefamandole and cefuroxime resistance to Escherichia coli K-12 recipients, the genetic analysis of exconjugants after the transfer of plasmids from Serratia strains to Proteus or Salmonella recipients showed that the cefoxitin resistance determinant was also co-transferred. (springer.com)

In subsequent transfer cycles of this plasmid, cefotaxime and cefoxitin resistance determinants segregated in contrast to the relative stability of plasmids derived from Klebsiella strains in subsequent transfer cycles. (springer.com)

Cefotaxime binds to one or more of the penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death. (drugsupdate.com)

Cefotaxime can also be given before certain types of surgery that are associated with an increased risk of infection, for example abdominal, bowel, heart or bone surgery, to help prevent infections after the operation. (netdoctor.co.uk)

In a prospective, randomized, double-blind study, we compared cefotaxime with nafcillin plus tobramycin in the treatment of serious bacterial infections. (annals.org)

We conclude that cefotaxime may be more effective and less toxic than nafcillin plus tobramycin for patients with serious bacterial infections. (annals.org)