R134a is an HFC refrigerant replacement for R-12. It is the global standard for new mobile air conditioning and can also be used to retrofit existing R-12 mobile air conditioning systems. It is also used in new medium- and high-temperature stationary commercial refrigeration, as well as chiller systems and home appliances. In addition, it can be used to retrofit existing R-12 refrigeration and air conditioning systems.

It is also used as cleaning agents, foam blowing agents and propellant.