GenAge entry for IL7 (Homo sapiens)

Gene name (HAGRID: 167)

Potential relevance to the human ageing process

Main reason for selection

Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems

Description

IL7 stimulates the proliferation of lymphoid progenitors. Mice without IL7 cease producing B lymphocyte after 7 weeks of age [772]. Declines with age in IL7 production have been associated with thymic atrophy [219]. Although IL7 could play a role age-related changes, such as ageing of the immune system, its role in human ageing is unknown.