Valinomycin

Abstract

Valinomycin is an antibiotic produced by certain strains of Streptomyces. It was first isolated by Brockmann and Schmidt-Kastner (1955) from the mycelium of cultures of Streptomyces fulvissimus, strain Ihr 582. The characteristics of this strain have been described by Lindenbein (1952). The organism was grown in stationary culture for 20 days at 27° on aqueous medium containing 2 vol.-% glycerol, 0.85% NaNO3, 0.18% KH2PO4, 0.12% K2HPO4, 0.05% FeSO4, 0.2% NaC1, 0.05% MgSO4, and 5 vol.-% aqueous yeast extract (Brockmann and Schmidt-Kastner, 1955). A better yield (approximately 90 mg/liter of culture) was obtained by growing the organism on this medium at 37° (Brockmann and Geeren, 1957).