Previous GeneCards Identifiers for KRT72 Gene

Summaries for KRT72 Gene

Entrez Gene Summary for KRT72 Gene

Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells. The type II keratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This gene encodes a type II keratin that is specifically expressed in the inner root sheath of hair follicles. The type II keratins are clustered in a region of chromosome 12q12-q13. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jun 2009]

GeneCards Summary for KRT72 Gene

KRT72 (Keratin 72, Type II) is a Protein Coding gene.
Diseases associated with KRT72 include pachyonychia congenita.
GO annotations related to this gene include structural molecule activity.
An important paralog of this gene is KRT82.

mRNA Expression by UniProt/SwissProt for KRT72 Gene

Tissue specificity:Highly expressed in hair follicles from scalp and eyebrow. Also expressed in palmoplantar epidermis. Not expressed in face skin despite the presence of fine hairs histologically. In hair, it is specifically present in the inner root sheath (IRS) of the hair follicle. Present in the IRS cuticle, but not in Henle or Huxley layers of the IRS. In the IRS cuticle, its presence is delayed up to the height of the apex of the dermal papilla (at protein level).