Dopamine (3-hydroxytyramine) is a well-known catecholamine neurotransmitter involved
in multiple physiological functions including movement control. Here we report that
the major extracellular metabolite of dopamine, ...

The beta-adrenergic receptor kinase is an enzyme, possibly analogous to rhodopsin
kinase, that multiply phosphorylates the beta-adrenergic receptor only when it is
occupied by stimulatory agonists. Since this kinase may ...

An alpha 2-adrenergic receptor subtype has been cloned from a human kidney cDNA library
using the gene for the human platelet alpha 2-adrenergic receptor as a probe. The
deduced amino acid sequence resembles the human platelet ...

A number of lines of evidence suggest that cross-talk exists between the cellular
signal transduction pathways involving tyrosine phosphorylation catalyzed by members
of the pp60c-src kinase family and those mediated by ...

Pharmacologic, biochemical, and genetic analyses have demonstrated the existence of
multiple alpha 2-adrenergic receptor (alpha 2AR) subtypes. We have cloned a human
alpha 2AR by using the polymerase chain reaction with ...

Release of endogenous dynorphin opioids within the spinal cord after partial sciatic
nerve ligation (pSNL) is known to contribute to the neuropathic pain processes. Using
a phosphoselective antibody [kappa opioid receptor ...

Homologous (agonist-specific) desensitization of beta-adrenergic receptors (beta ARs)
is accompanied by and appears to require phosphorylation of the receptors. We have
recently described a novel protein kinase, beta AR ...

Chronic exposure of various cell types to adrenergic agonists leads to a decrease
in cell surface beta 2-adrenergic receptor (beta 2AR) number. Sequestration of the
receptor away from the cell surface as well as a down-regulation ...