The Application of SALS (Statistical Analysis with the Least Square) to Michaelis-Menten Pharmacokinetics of Phenytoin

Abstract

Phenytoin is a common drug as an anticonvulsant. The therapeutic drug monitoring is required for phenytoin because of its narrow therapeutic range. The metabolism of phenytoin is saturated within the clinical doses. The saturation kinetics can be evaluated by two parameters, Vmax, maximal metabolic velocity and Km, Michaelis-Menten constant.