Vampire Detective (not to be confused with Vampire Prosecutor, though they do come from the same production team) follows Yoon San (Lee Joon), a prickly detective who decides to become a private investigator after a painful accident during his police days. When he suddenly becomes a vampire, he decides to investigate the mystery of his own past.

Lee Se Young plays Han Gyeol Wool, a smooth con woman who joins the team after losing her beloved brother in a tragic accident.