Adrian is first introduced as the new classics literature teacher and where student Lori Anderson confesses her love but is rejected. Her gang takes offense and takes it into their own hands to serve punishment and corner Adrian in an alleyway and surround him but before they can do anything they're interrupted by Lucas, who had followed them out of concern for Adrian. They form a stronger bond once they share the secret of Cybersix's existence and Lucas is able to confide in him about it, but they also seem to share a genuine relationship outside of Cybersix.

Adrian is passionate about his job and has a no-nonsense attitude about it in class, especially to the lovesick Lori and her gang of delinquents, and is seen lightheartedly annoying Lucas with quotes of literature. And in the comics, he even translates works into other languages in his free time for fun.

The purpose of using the persona of Adrian for a disguise for Cybersix is to hide from her evil creator, the mad scientist Doctor Von Reichter who seeks to destroy her. To live a normal life, she took up the identity of Adrian and worked to support herself. She is initially cold and distant with other people for this reason, but gradually, she meets and befriends new people.

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Adrian has an average appearance in both height and build, black hair brushed up and slicked back, wears large round eyeglasses and is often seen wearing his work clothes which consist of a white collar shirt, an orange tie, blue pants and a trench coat. The clothes are at least a size higher than his natural measurements, so that any noticeable features shown from the Cybersix persona are well concealed.

The live-action series reverses Adrian's and Cybersix's hairstyle with Adrian's hair being brushed forward while Cybersix's is slicked back.

Adrian's personality depends on his situation. When teaching class, he is a stern no nonsense teacher, who doesn't tolerate disruption of any kind. Especially when it comes from the amorous Lori. However outside of class, he's a reserved, but nice person. Often keeping to himself, unless hanging out with Lucas. While he does keep his identity as Cybersix a secret, there are times when that persona breaks through. From major events like, Mysterious Shadow, when he reacts in shock to the vial of Sustenance Lucas stole, to minor events such in Full Moon Fascination, where he shows jealousy of Lucas' time with Elaine. He also proves to be a bad liar. In Lori is Missing, after Lori catches Cybersix with who she assumed was Adrian (it was really Data 7). Lori tells Lucas who immediately accuses Adrian of knowing and having and affair with Cybersix. While Adrian truthfully denies the affair, he stumbles when asked if he knew Cybersix. Only answering with "You wouldn't understand." Causing a rift between the two.

Cybersix comes across the alter ego of Adrian Seidelman as a young child, on the run from Von Reichter and struggling to pass borders without identification to find safety in a large city.
One night, she witnesses a fatal car accident and, upon seeing a young boy with his ID intact, decides to bury him and pretend he is still alive by stealing his identity. As Adrian, she manages to reach the city of Meridiana, making a living as a courier, living in the attic of a woman named Tina, and receives an education through mail. He eventually makes it to university and gets his bachelor's degree, his own apartment and a teaching position at the local high school.

It isn't until Adrian runs out of sustenance that he attacks a Techno working as a prostitute, and knowing it's dangerous to continue this as his civilian identity, takes the prostitute's outfit from a closet and lives out the nights as Cybersix.

Cybersix expresses her dislike of being Adrian and her guilt for stealing his identity. In Volume 6, the real Adrian's grandfather, Abraham Seidelman, sends a private detective to find his grandson in hopes of giving over his wealth before he dies. The two meet and she rejects the offer, but the man stubbornly refuses this and still wishes to give Adrian an inheritance. However, at Abraham's death, Adrian is told since he was proclaimed dead years ago, the money will go to a public foundation.

Not much of Adrian's history is known other than he used to live in a small fishing village and what's revealed in his work file. Adrian graduated from Okanagan University, majored in humanities literature, and wrote a B.A thesis titled "The Canterbury Tales and Dadaism in Modern English." His previous work experience included teaching at two other high schools, Fraser Valley High and Cariboo High, the latter being a part-time job. He currently lives in an apartment at 11107 Gateway Avenue, S., room 4-A, at Meridiana, SBC B6V 8B1. His phone number is 333-5829 and does not have a fax number or e-mail address.

Adrian is good friends with Lucas and the two often hang out together, such as during their lunch breaks and after hours at the cafe, and they presumably do other things together.
While the cartoon series quickly resolved the love triangle between Adrian, Cybersix and Lucas, the comic series leaves the matter largely unresolved. Things are complicated when Cybersix tries to keep up the lie that she and Adrian are romantically involved to inspire jealousy out of Lucas.

Adrian and Data 7 don't interact much with each other but being siblings, they're naturally close. When Data 7 knows something and needs to tell Adrian, such as when Lori went missing and when he found Von Reichter's secret base, Adrian will instinctively know what he's trying to say. And when Cybersix became injured and she tried to leave for work as Adrian, Data 7 became protective and attempted to block his path and later followed him around, and in the same episode, Data 7 appears to be giving Adrian a kiss.

Adrian Seidelman and Lori Anderson have a very complicated relationship. While it's pretty obvious, Lori is infatuated with him, she never pays attention to his class. Implying her attraction is mainly physical. Whilst Adrian doesn't share the same feelings with her and views her as a disruption of his class. Despite that, their relationship does share instances of it being deeper. On the Lori side of things, she is actually hurt when she apparently stumbles upon an alleged affair between him and Cybersix, not even knowing that they are one and the same. She also shows some concern over him after he fell into the water, from an attack by Griselda. Adrian in turn does care about Lori's wellbeing when he finds out she's missing and in the Cybersix persona, went as far as setting Jose's drill tank on fire with him in it for his role in her kidnapping. He also shows concern for Lori when he finds her semi conscious after an encounter with The Eye. Before Cybersix goes out to confront Dr. Von Reichter, she reveals her dual identity to Lori and gives her Adrian's glasses to remember her by. Although Lori didn't like Cybersix after her first meeting with her, it seemed that she still loves Adrian regardless of who he really is, since she was willing to go with Lucas to help find her. When the lab explodes, Lori is just as devastated as Lucas when she thought Cybersix was dead. To add insult to injury, unlike Lucas, she never got a hint that Cybersix might still be alive.

On the 2014 DVD commentary with Cathy Weseluck, the English voice actor for Cybersix, Weseluck has stated her opinion on the dual identity protagonist and its possible relation to real world transgenderism.

In the final episode, The Final Confrontation, Cybersix gives her eye glasses to Lori, who in turn gives it to Lucas. Due to the ambiguity and cliff ending, it's unclear if Lori and Lucas now know Adrian is Cybersix's secret identity.

Weseluck has also expressed her belief that Lucas has found out that Adrian was Cybersix in disguise.

She also said that if Lucas were to meet Cybersix at Adrian's apartment, they would not say anything, they would just be happy to see the other.