Immunization maintains strong performance made in last quarter century

Millions more could be saved with new vaccines, stronger health systems

Press release WHO/GAVI/PATH

4 October 2005 | Lyon, France -Immunization at the global level has progressed very well during the past 25 years, but further increases in coverage would save the lives of millions more who do not yet benefit from this protection, said a group of immunization partners at the World Vaccine Congress in Lyon, France.

This conclusion was drawn after an analysis of the latest immunization global data, published today. The World Health Organization (WHO) and UNICEF, with financial support from the United States Centers for Disease Control and Prevention, conduct world-wide monitoring and work closely with Ministries of Health to produce estimates of immunization coverage each year. The major findings are summarized as follows:

Global immunization coverage with three doses of diphtheria-tetanus-pertussis (DTP3) vaccine has been sustained at 78% for the year 2004. 1

102 countries have reached DTP3 coverage of 90% or more and 80 countries are within the 50-89% range. Ten countries — in Africa, Asia and Central America — have coverage levels below 50%. 2

There has been dramatic expansion in the use of hepatitis B and Haemophilus influenzae type b (Hib) vaccines. 153 countries now routinely vaccinate children with hepatitis B vaccine, up from 12 countries in 1990. 92 countries include Hib vaccine in their routine immunization systems, up from four countries in 1991.

27 million infants were not immunized with DTP3 in 2004, putting them at risk for life-threatening illnesses. 3

Five countries—China, India, Indonesia, Nigeria and Pakistan—each have more than 1 million unvaccinated children accounting for 16.3 million (more than 60%) of the world's 27 million unvaccinated children. 4

"The spectacular gains made in immunization in the '80s have been sustained. This is the result of strong commitment of countries and partners, effective strategies and substantial financing. But, we can and must do better. Vaccines must be brought to the millions who are currently un-reached and all people must benefit from new, life-saving vaccines. Our mission is to protect all people at risk from vaccine-preventable diseases," said Dr Jean-Marie Okwo-Bele, Director of the WHO Department of Immunization, Vaccines and Biologicals.

The estimated number of deaths in all age groups from diseases preventable by vaccines currently recommended by WHO, such as measles, hepatitis B, Hib, pertussis, tetanus and others, was 2.1 million in 2002, including 1.4 million children under age five.

Yet, in 2003 alone, immunization averted more than 2 million deaths from vaccine-preventable diseases. An additional 600 000 hepatitis B-related deaths that would have otherwise have occurred in adulthood were also prevented. Historically, immunization is one of the greatest public health success stories ever: smallpox was eradicated in 1980, the global incidence of polio has been reduced by 99% and in just five years (1999-2003) global measles deaths have decreased by 39%, with a 46% reduction in Africa.

Immunization is at an exciting turning point. Unprecedented new resources for immunization are being made available through the International Finance Facility for Immunization (IFFIm) towards which a group of European countries committed nearly US $4 billion last month.

“IFFIm funding will enable us to scale up immunization and introduce new vaccines to millions of the world’s poorest children. Substantial funding to support health systems is needed if countries are going to expand access to the traditional vaccines and manage and deliver the new vaccines,” said Dr Julian Lob-Levyt, Executive Secretary of the Global Alliance for Vaccines and Immunization (GAVI).

A revolution is expected in the next decade in the ways that vaccines are designed, manufactured, financed, delivered and administered. Major breakthroughs are occurring in vaccine development. About 20 new or improved vaccines are anticipated within the next ten years.

“Dramatic progress has been made in the development of several new vaccines for diseases that afflict children in developing countries — new vaccines that are capable of protecting the lives of even more children,” said Dr John Wecker, Director, Immunization Solutions at PATH, an international nonprofit organization. “The challenge we face is to ensure that all children who could benefit from these vaccines will have access to them.”

WHO and UNICEF have produced a new Global Immunization Vision and Strategy for 2006-2015 which aims to protect more people, of all age groups, against more diseases and sets a number of immunization goals.

1 WHO and UNICEF routinely monitor national infant immunization coverage for protection against tuberculosis, diphtheria, tetanus, pertussis, polio, measles, hepatitis, and Haemophilus influenzae type b. DTP coverage is commonly used as the indicator vaccine for immunization system performance. In 1980, global immunization coverage with DTP3 was low at 20% and only about 30% of countries had a formal infant immunization system, but dramatic gains were made during the 1980s and these have been sustained until present, despite an increasing world population. Of the 124.6 million infants born in 2004 and surviving to their first year of life, more than 108 million received at least one vaccine and 95 million received BCG vaccine against tuberculosis, DTP3, oral polio and measles vaccines. 192 countries now have an infant immunization system.

WHO is the United Nations specialized agency for health. Its objective is the attainment by all people's of the highest possible level of health. WHO has 192 Member States. More information is available at http://www.who.int; for information on immunization, please see: http://www.who.int/vaccines

The IFFIm and GAVI: The International Finance Facility for Immunization (IFFIm) will be implemented through the Global Alliance for Vaccines and Immunization (GAVI), an historic alliance of all the major stakeholders in immunization. Alliance members include a wide range of development partners: developing country and donor governments, WHO, UNICEF, the World Bank, the vaccine industry (from industrialized and developing countries), research and technical agencies, NGOs, the Bill & Melinda Gates Foundation, and The Vaccine Fund, the resource and financing arm of GAVI.

PATH, an international, nonprofit organization, creates sustainable, culturally relevant solutions that enable communities worldwide to break longstanding cycles of poor health. By collaborating with diverse public- and private-sector partners, PATH helps provide appropriate health technologies and vital strategies that change the way people think and act. PATH’s work improves global health and well-being. Visit www.path.org for more information about PATH.