Previous GeneCards Identifiers for HBS1L Gene

Summaries for HBS1L Gene

Entrez Gene Summary for HBS1L Gene

This gene encodes a member of the GTP-binding elongation factor family. It is expressed in multiple tissues with the highest expression in heart and skeletal muscle. The intergenic region of this gene and the MYB gene has been identified to be a quantitative trait locus (QTL) controlling fetal hemoglobin level, and this region influnces erythrocyte, platelet, and monocyte counts as well as erythrocyte volume and hemoglobin content. DNA polymorphisms at this region associate with fetal hemoglobin levels and pain crises in sickle cell disease. A single nucleotide polymorphism in exon 1 of this gene is significantly associated with severity in beta-thalassemia/Hemoglobin E. Multiple alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, May 2009]

No data available for
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery ,
mRNA differential expression in normal tissues and
Phenotype-based relationships between genes and organs from Gene ORGANizer
for HBS1L Gene