Uterine Testing

How to Test a Uterine Biopsy For HHV-6A

Coppe Laboratories (USA): Tissues can be sent frozen and shipped on dry ice for HHV-6A/B PCR DNA testing with the results being given as a ratio of HHV-6 genome to cellular genes ($385). Coppe asks that no buffer, water or saline be added to the sample and that it be shipped in a sterile tube/container. Code: 1111; (CPT 87532×2)

ViracorIBT (USA): Quantitative PCR DNA testing for HHV-6. It does not differentiate between HHV-6A and HHV-6B. They prefer frozen specimens with no added fluid, water or saline, shipped overnight with dry ice. No slides or paraffin embedded tissue accepted. Code: 6506

IKDT (Germany) Quantitative PCR DNA testing for HHV-6A/B . They can also test for mRNA to see if the virus is active. Ship tissue frozen overnight for DNA testing or send glass slides for immunohistochemistry analysis. For mRNA testing, send sample in RNALater solution.

HHV-6A vs. HHV-6B. Please note that Coppe and IKDT can differentiate HHV-6A from HHV-6B, but most labs do not have this capability. Only HHV-6A has been found in uterine biopsies of women with unexplained infertility (Marci 2016).

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About HHV-6

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ABOUT THE HHV-6 FOUNDATION

The HHV-6 Foundation in a non-profit entity founded to encourage scientific exchange between investigators and to provide pilot grants for promising scientific and clinical research on the under- appreciated viruses HHV-6A and HHV-6B.

The Foundation sponsors international conferences and supports scientists and clinicians seeking to clarify the role of the two HHV-6 viruses in disease. Since HHV-6A and HHV-6B can smolder in the brain and other organs without circulating in the peripheral blood or plasma, identifying chronic infection is a challenge.