Depends on if you plan on winning it all this year. If so and Bautista is the piece you need, make the trade. However, if you think it may be a few years before you compete then I would stick with what you have. Profar and Wheeler for a long time would be nice to have, whereas Bautista might have 4-5 more years in him (and 2-3 at a high level, perhaps).

And yet again, if you have plenty of nice prospects and aren't worried about losing one of the bigger named prospects around, then make the trade. It really depends on your situation.