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Abstract

Background—A lack of effective and safe antiarrhythmic drugs for atrial fibrillation (AF) rhythm control is an unmet clinical need. Multichannel blockers are believed to have advantages over single-channel blockers for AF, but their development has been completely empirical to date. We tested the hypothesis that adding K+-channel blockade (KCB) improves the atrial-selective electrophysiological profile and anti-AF effects of optimized Na+-channel blockers (NCBos).