Crixivan

"Current prevention strategies have reduced the incidence of HIV worldwide, but that decline has slowed in recent years. We need new prevention strategies if we are to realize President Obama's goal of an AIDS-free generation. Targeting people who"...

Crixivan

DRUG DESCRIPTION

CRIXIVAN® (indinavir
sulfate) is an inhibitor of the human immunodeficiency virus (HIV) protease.
CRIXIVAN Capsules are formulated as a sulfate salt and are available for oral
administration in strengths of 200 and 400 mg of indinavir (corresponding to
250 and 500 mg indinavir sulfate, respectively). Each capsule also contains the
inactive ingredients anhydrous lactose and magnesium stearate. The capsule
shell has the following inactive ingredients and dyes: gelatin and titanium
dioxide.

The chemical name for indinavir
sulfate is [1(1S,2R),5(S)]-2,3,5-trideoxy-N-(2,3-dihydro-2-hydroxy-1Hinden-1-yl)-5-[2-[[(1,1-dimethylethyl)amino]carbonyl]-4-(3-pyridinylmethyl)-1-piperazinyl]-2-(phenylmethyl)D-erythro-pentonamide
sulfate (1:1) salt. Indinavir sulfate has the following structural formula:

Indinavir sulfate is a white to
off-white, hygroscopic, crystalline powder with the molecular formula C36H47N5O4
• H2SO4 and a molecular weight of 711.88. It is very
soluble in water and in methanol.

What are the possible side effects of indinavir (Crixivan)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop taking indinavir and call your doctor at once if you have any of these serious side effects:

pain in your side or lower back, blood in your urine;

pale skin, easy bruising or bleeding, confusion or weakness;

signs of a new infection, such as fever or chills, cough, or flu symptoms;

What are the precautions when taking indinavir sulfate (Crixivan)?

Before taking indinavir, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.