Autoimmune Hemolytic Anemia, NZB Mice

Abstract

Splenomegaly is the most prominent lesion observed in moribund animals. Hepatomegaly and generalized lymphadenopathy are also usually present. All three of these lesions may develop initially at approximately 6 months of age, and increase in magnitude and frequency as the anemia becomes increasingly severe (Creighton et al. 1979). The thymus may or may not be grossly prominent.