CannPal is now working with a Melbourne-based integrated medical laboratory to identify the drug’s effects on key chemokine and cytokines associated with the activated pain and inflammatory genes highlighted in the phase I studies.

The results of this in conjunction with the gene expression data will support the dose justification for CPAT-01 before commencing the clinical program.

Phase II study planned

CannPal has generated significant data on the pharmacokinetic and gene expression profiles of cannabinoids in dogs.

This will be used to begin protocol development for the first phase II study, a pilot dose determination study in client-owned animals with OA to clinically validate the effects seen in phase I studies.

The company aims to begin recruitment for this study during the current quarter.

Testing in cats

CannPal has also received ethics approvals to commence the testing of CPAT-01 in cats.

As cats represent over 25% of the companion animal drug market, there’s a clear unmet need for safe therapeutics that can be used long-term to treat pain and inflammation.