Summary and Conclusions

The implantation of whole mouse pituitaries into ovariectomized C3H mice on full feeding following a period of caloric restriction did not result in an acceleration of onset of the subestrous state characteristic of such mice. In fact, control mice implanted with gastrocnemius muscle showed a somewhat greater tendency to reach the subestrous state at an earlier time. These results lend no support to the hypothesis that pituitary hypofunction in caloric underfeeding is the critical limiting factor in preventing estrogen production in ovariectomized mice with resulting adrenal cortical tumors.

Footnotes

↵* This work was done under an institutional grant-in-aid from the American Cancer Society upon recommendation of the Committee on Growth of the National Research Council.

↵† This author carried out his part of the work on this paper during tenure of a fellowship in Cancer Research of the American Cancer Society, upon recommendation of the Committee on Growth of the National Research Council.