Poison on the Streets

Poison on the Streets automatically starts when you speak to Ben Urich to complete Chapter 3 and The Tablet Chase, and is the first mission of Chapter 4. You'll need to speak to the S.H.I.E.L.D. pilot on the central platform, and you'll be sent to the first area of the chapter.

You'll automatically unlock the Lower East Side waypoint when you come. Multiple Man is standing right by the waypoint, so speak to him to advance the story.

After that, as usual, explore around and look for instances to gain your XP before continuing on with the story. The Lower East Side is pretty small, and it won't take you too long to explore its every nook and cranny. The enemies are generally weak, but there are some hopped up on Mutant Growth Hormone, or MGH. These guys hit pretty hard, and if you're swarmed, you'll take some solid damage even if you've been running through the game with impunity so far.

When you're ready to proceed, head through the door with the pulsing icon on the mini-map, which is generally located in the center of the are.

There aren't any waypoints in here, so if you are defeated, it'll be a somewhat long walk back. Be careful.

You'll be facing A.I.M. guards for the most part in here. They'll hit just a bit harder than the common minions you're used to, but they take just as few hits as normal. You shouldn't have many problems here, and the enemies don't require any special strategies to beat.

The only enemy of note is the MGH Blaster, who may slow you down with one of his energy blasts. It's not a huge deal for ranged heroes, but if you're a tank or a melee DPS, it'll be rather annoying. You may want to take these guys out first to minimize the chance you get slowed.

The first pointed map marker you see points to a “shiny briefcase,” which you need to collect for evidence against Kingpin. It's guarded, but you'll have to deal with quantity, not quality: the enemies will swarm you near the briefcase, but won't put up much of a fight. Once they're down, you'll be able to grab it.

There won't be much else in the factory once you grab the briefcase. A little exploration later, you'll find...

Tombstone is the most direct boss or mini-boss you've ever faced. He has only two attacks: a swinging punch, and a jumping ground smash. He has no ranged options, and he doesn't move too fast, so ranged fighters can generally just run around and pick him off from a distance. He does hit hard, and he takes quite a few hits, but it's nothing to any level you haven't seen before. As long as you have some healing kits, you should be fine with no unusual strategies.

Defeating him will create an orange portal, which will take you back to the Lower East Side. Once you're there, you'll need to make your way to a subway. Similarly to finding the other subway back in Chapter 1, you'll want to explore the Lower East Side until you find a long “alley” that extends only a single direction. At the end of that alley will be the entrance to the subway.

The Crosstown Subway waypoint and a police officer will be there to greet you. Speak to her to trigger the Subway Sweep event, then continue on.

The subway features enemies of Kingpin's Maggia, and they're all pretty weak, especially compared to the MGH enemies you've had to deal with up till now. The subway is linear, so you'll find Ben Urich eventually. Speak to him, and you'll clear the mission, as well as advance the story.