Antiviral activity of flavones and potentiation by ascorbate.

J Gen Virol 1988 Jul;69 ( Pt 7):1749-51 (ISSN: 0022-1317)

Vrijsen R; Everaert L; Boeye A

Department of Microbiology and Hygiene, Vrije Universiteit Brussel, Belgium.
We compared the anti-poliovirus activities of three flavones, quercetin,
luteolin and 3-methylquercetin, which differ only at ring position 3.
3-Methylquercetin was the most potent compound. Quercetin exhibited antiviral
activity only when protected against oxidative degradation by ascorbate.
The antiviral activity of luteolin was comparable to that of ascorbate-stabilized
quercetin.

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