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Margolies (then Margolies-Mezvinsky) was elected to Congress in the 13th district in 1993. She’d told reporters she would oppose Clinton’s budget that year, which included tax increases on the wealthy, but changed her mind after talking with Clinton just before the vote.

The vote dogged her throughout the 1994 campaign, the year of the Newt Gingrich-led Republican Revolution that saw the GOP win the House for the first time since 1952. Margolies was defeated by Republican Jon Fox — and became the symbol of losing a congressional seat over one controversial vote.

Margolies’s relationship with the Clintons goes beyond her fateful 1993 vote: Her son, Mark Margolies-Mezvinsky, married Chelsea Clinton in 2010. Her campaign will likely receive some high-profile help from the Clinton family.

Still, Margolies is joining an already crowded Democratic primary: Five other candidates have already announced including state Sen. Daylin Leach and state Rep. Brendan Boyle.

Since leaving Congress, Margolies founded Women’s Campaign international, a nonprofit aimed at increasing women’s leadership across the globe. She also teaches classes at the University of Pennsylvania Fels Institute of Government.