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Yeah, you better. Poison Ivy sensitivity can turn up out of the blue. I spent my childhood running around overgrown forests full of the stuff. Never had even the tiniest reaction. Then, in college, a bunch of fellow art students and I broke into an abandoned industrial site to take photographs (so you might say we got what we deserved) and there was a lot of it. Two or three days later, my entire body was swollen, weepy, drippy, itchy, red, and disgusting. I had to have prednisone to clear it up. Since that day, I can't even stand within 10 feet of a plant without getting a rash.

Once you get a reaction, any area that had been exposes and broken out can break out again. My friend, who is very sensitive to the stuff, got into the stuff when he was about 4, and had a bad breakout. Being 4, he had no concept of what was going on, and no sense of self-control. So, eventually, he spread the stuff all over his body, and especially into two very sensitive areas. Now, whenever he is careless and gets exposed, these two areas break out with reactions.

Once you get a reaction, any area that had been exposes and broken out can break out again. My friend, who is very sensitive to the stuff, got into the stuff when he was about 4, and had a bad breakout. Being 4, he had no concept of what was going on, and no sense of self-control. So, eventually, he spread the stuff all over his body, and especially into two very sensitive areas. Now, whenever he is careless and gets exposed, these two areas break out with reactions.

I don't know about this ^ as supposedly the contents of the blisters do not spread the rash.

I DO know about poison ivy going systemic. If suppressed by prednisone, the inflammation can kind of go "internal". Then it will break out anywhere it damn well pleases.

I spent a whole summer on prednisone for poison ivy. . .complete with Cushings syndrome because of the suppression of my adrenal glands. I had poison ivy up my rectum!! It was not fun.