Browse our anti-alpha Actinin 4 (ACTN4) Antibodies

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anti-Actinin, alpha 4 Antibodies (ACTN4)

On www.antibodies-online.com are 110 Actinin, alpha 4 (ACTN4) Antibodies from 27 different suppliers available. Additionally we are shipping alpha Actinin 4 Kits (20) and alpha Actinin 4 Proteins (9) and many more products for this protein. A total of 156 alpha Actinin 4 products are currently listed.

anti-dsDNA Fab may enhance F-actin formation by the proprietary modification of alpha-actinin-4

Together, these results indicate that alpha-actinin and the actin cytoskeleton are important components of the cisternal organelle that are probably required to stabilize the AIS.

Results suggest that ACTN4 is essential for maintaining normal spreading, motility, cellular and nuclear cross-sectional area, and contractility of lung fibroblasts by maintaining the balance between transcellular contractility and cell-adhesion.

newly developed mouse model of ACTN4-associated FSGS suggests a cause-and-effect relationship between actin cytoskeleton dysregulation by mutant alpha-actinin-4 and the deterioration of the nephrin-supported slit diaphragm complex.

nonsarcomeric alpha-actinin-4 is involved in the regulation of cell movement

ACTN4 has a role promoting tumorigenicity and regulating cell motility

The different genetic defects in Actn4 produce a spectrum of glomerular morphologic lesions depending on the specific combination of normal and/or defective alleles.

Although actinin-4 bound to JRAB/MICAL-L2 without Rab13, the actinin-4-JRAB/MICAL-L2 interaction was enhanced by Rab13 activation.

Alpha-actinin-4 K256E triggers several metabolic abnormalities, which may lead to glomerular epithelial cell injury and glomerulosclerosis.

Human Actinin, alpha 4 (ACTN4) interaction partners

Through driving a feedforward signaling axis of ACTN4-RIPK1-NF-kappaB.

we summarize current knowledge regarding therapeutic strategies for locally advanced pancreatic cancer and discuss the potential development of personalized medicine using ACTN4 measurement for patients with locally advanced pancreatic cancer--{REVIEW}

Actinin-4 directly binds to the cytosolic tail of CD147 and governs the assembly of CD147-beta2-adrenergic receptor complexes in highly ordered clusters at bacterial adhesion sites.Actinin-4 is recruited to bacterial adhesion sites.

significantly upregulated in the cervical mucus of women with preterm labor with microbial invasion of the amniotic cavity

These results demonstrate that both actinin-1 and actinin-4 participate in the assembly of F-actin at invadopodia. Additionally, actinin-4 may have a selective advantage in accelerating invadopodia-mediated invasion of carcinoma cells.

Fascin and alpha-actinin intrinsically segregate to discrete bundled domains that are specifically recognized by other actin-binding proteins.

Suggest that ACTN4 as a potential predictive biomarker for efficacy of adjuvant chemotherapy in stage-IB/II patients with non-small cell lung cancer, by reflecting the metastatic potential of tumor cells.

High ACTN4 expression is associated with Lung Squamous Cell Carcinoma.

Our findings indicate that ACTN4 promotes EMT and tumorigenesis by regulating Snail expression and the Akt pathway in cervical cancer. We propose a novel mechanism for EMT and tumorigenesis in cervical cancer.

Study found a functional Validation of an Alpha-Actinin-4 Mutation as a Potential Cause of an Aggressive Presentation of Adolescent Focal Segmental Glomerulosclerosis.

SERPINE1, ANGPLT4, CCL20, and SAA1 as well as the NF-kappaB (p65) binding sites on GR-transrepressed promoters such as IL-1beta, IL-6, and IL-8 Taken together, our data establish ACTN4 as a transcriptional co-regulator that modulates both dexamethasone-transactivated and -transrepressed genes in podocytes.

Here, we report the identification of a novel, disease-causing ACTN4 mutation (p.G195D, de novo) in a sporadic case of childhood FSGS using next generation sequencing.

the calmodulin domain of human alpha-actinin-4 binding to the linker region was important for regulating the distance between actin and actin-binding domain.

This study identified alpha-actinin-4 as a novel NHERF1 interaction partner and provided new insights into the regulatory mechanism of the actin cytoskeleton by NHERF1.

Selective regulation of NF-kappaB gene targets may indicate involvement of ACTN4 in determining the specificity of cell response to NF-kappaB activation in cells of different types. (Review)

ZYX defective binding to ACTN4, which occupies focal adhesions instead of ACTN1, induces the formation of immature focal adhesions, resulting in the enhancement of cell motility and invasion.

alpha Actinin 4 (ACTN4) Antigen Profile

Antigen Summary

Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes. Mutations in this gene have been associated with focal and segmental glomerulosclerosis.