His Holiness Macarius II of Alexandria was the 69th Patriarch of Alexandria.

He was pious and ascetic from a young age, longing for the monastic life. He went to the desert of Scete and became a monk in the monastery of St. Macarius. He devoted himself to worship and spiritual struggle. He instructed himself by reading the Holy Scriptures, their interpretation and by contemplating on its meaning. He grew in virtues and was ordained a priest.

When Abba Mikhail, the 68th Pope of Alexandria, departed and the papal throne became vacant, a group of bishops and priests went into the wilderness of Scete. They assembled in the church with the elders of Scete. They remained there for many days, searching and scouting for who would be best for this position. Finally they unanimously agreed to choose Macarius for his good character and excellent attributes. They took him and bound him against his will, and he cried out and begged them with excuses to release him saying, "I am not fit to be raised to the dignity of the Papacy."

They brought him bound to the city of Alexandria and ordained him Patriarch. The deed of his appointment was read in the Church of Mu'allakah (The Church of the Holy Virgin) in the Greek, Coptic, and Arabic languages.

During his papacy, he added to his worship and piety. He taught and preached the people daily. He gave alms and did works of mercy to the poor and needy. During his papacy he never asked for any of the Church's money, but rather, he used to give a large portion of the contributions which he received to be spent on different righteous deeds. He completed 27 years in the papacy and departed in peace on September 15 (Thout 4) in 1122 A.D.