Abstract: Objective To investigate the clinical effect of high quality nursing intervention combined with vacuum sealingdrainage in the treatment of refractory wounds. Methods Ninety-six patients who had undergone refractory wounds treatmentin our hospital from June 2015 to June 2017 were selected as study subjects. The number of patients was assigned accordingto the time of admission and grouped by random number method. Two groups of patients were treated by vacuum assisteddrainage. The control group received routine nursing, while the observation group received high quality nursing intervention.The clinical efficacy, pain score, psychological state and satisfaction degree of wound healing were compared between thetwo groups. Results After intervention, the scores of HAMA and HAMD in the two groups were lower than those beforeintervention, and the decrease in the observation group was more obvious, the differences were statistically significant(P ＜0.05).The clinical effective rate of the observation group was 93.75%, which was significantly higher than that of the control group(79.17%,P ＜0.05). The VAS score, length of stay, hospitalization expenses and wound healing time in the observation groupwere significantly better than those in the control group(P ＜0.05). The total satisfaction rate of the observation group was91.67%, which was significantly higher than that of the control group (66.67%,P ＜0.05). Conclusion The use of high qualitynursing intervention combined with negative pressure drainage technology can significantly improve the clinical efficacy ofrefractory wound, shorten the wound healing and hospitalization time, improve the patient’s psychological state and improve thepatient’s recovery satisfaction, which is worthy of clinical application.