As is the case with many of Academy Award-winning filmmakers Joel and Ethan Coens’ projects, “The Ballad of Buster Scruggs,” a six-part Western anthology that leads audiences through the heart of the unforgiving American Frontier, is a worthy addition to the Coens’ darkly funny cinematic canon, which includes classics like “Fargo” and “The Big Lebowski” and lesser-known gems like “A Serious Man.”

Do not, however, go into the Coens’ newest horse opera thinking they are going to deliver another “True Grit” or “No Country for Old Men.” It’s evident from those critically acclaimed films that they have the Western genre down pat, but “Buster Scruggs” is a different kind of movie altogether. Like “The Sisters Brothers” — another unconventional and philosophical cowboy dramedy that hit theaters a couple of months ago — it’s a unique and unpredictably screwy ride.

Of the film’s six vignettes, the one that would win an Oscar on its own in the Best Short Film category is the 20-minute opening segment, aptly called “The Ballad of Buster Scruggs,” and featuring actor Tim Blake Nelson (“O Brother, Where Art Thou?”) as the title character, a neatly dressed outlaw and “songbird,” who trots into town on horseback with his guitar only to find a heap of trouble waiting for him at every turn. With the Coens’ whip-smart dialogue and Nelson’s confident and wildly fun performance, “Buster Scruggs” starts off incredibly strong.

While the rest of the segments don’t reach the heights of the first, all of them offer viewers something special — a series of fantastic yarns spun with distinctive themes, pacing and colorful characters. In the segment “Near Algodones,” an unnamed cowboy (James Franco) walks into a dusty bank to rob it but finds his neck at the end of a noose when the teller (Stephen Root) fights back.

In “Meal Ticket,” The Impresario (Liam Neeson) serves as the caretaker to The Artist (Harry Melling), a limbless thespian who recites dramatic verse for townspeople across the Old West until his traveling companion discovers he might have a new plan. In “The Gal Who Got Rattled,” a young woman named Alice Lonabaugh (Zoe Kazan) is left in an uncomfortable position when her brother dies on the Oregon trail. Her future is uncertain until wagon train guide Billy Knapp (Bill Heck) offers her a start at a new life.