Preparation and Storage

General Info

Alternative names

GrpE like 2, mitochondrial

GrpE protein homolog 2

GRPE2_HUMAN

GRPEL 2

Grpel2

mitochondrial

Mt GrpE#2

Mt-GrpE#2

see all

Function

Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins. Stimulates ATPase activity of mt-HSP70. May also serve to modulate the interconversion of oligomeric (inactive) and monomeric (active) forms of mt-HSP70.