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Analysis: This is probably happening due to the Back Pressure feature in Exchange Transport service.

Solution: First step is to reconfigure the Transport service you can do this by doing the following: Open the "EdgeTransport.exe.config" file which is located Program Files/Microsoft Exchange Bin folder.

Disable Resource monitoring or change the monitoring configuration:

Open the "EdgeTransport.exe.config" file with notepad and change resource values or even easier just disable the monitoring completely.If you are changing the resource values the string should go fromadd key="EnableResourceMonitoring" value="true" /Toadd key="EnableResourceMonitoring" value="false" /Once this is done save the file and restart the Microsoft Exchange Transport servic