Virologic, Immunologic and Immunogenetic Correlates

This protocol focuses on the characteristics of the virus in the donor (originally HIV+) and recipient (originally HIV-) in heterosexual couples who have transmitted HIV; the genetic characteristics of the hosts as they relate to ‘contagion’, ‘vulnerability’ and ‘resistance’ to HIV infection and disease; and the immune responses that are associated with either transmission, or non-transmission despite many exposures.