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About Me

Hi! My name is Qadoshyah and I'm the oldest of 11 kids. I live on a ranch in the beautiful country of Northeastern Oklahoma with my family. We are a large household with so many kids that we have various projects going on: We raise goats, pigs, sheep, and rabbits (I raise the rabbits - cute little mini lops) on our 44 acre ranch. Our ranch is also home to bullmastiffs, chickens, guinea hens, ducks, llamas, a donkey, a bottle calf, and several ranch dogs and livestock guardian dogs. The youngest two kids are boy/girl twins born in Feb. '05. The boy happens to have Down syndrome. He is such a blessing to our family :)! Our whole family is also gluten-free, which adds another interesting aspect to our large, active family. We also cook dairy-free & corn-free due to allergies a few kids have. Some of the family is also on the GAPS diet to restore gut health.

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The writers of this blog research and attempt to give what they believe is the most accurate and up-to-date information. Nonetheless, the information on this blog is simply opinions and does not in any way constitute professional legal or medical advice. Also, references or links to external, or third party websites, are provided solely for visitors' convenience and are not controlled nor monitered by us. Links taken to other sites are done so at your own risk.

Moreover, this blog and it's writers do not endorse or support religious views that are not consistent with the Bible. The only faith we have found that is faithful to Scripture can be found at www.atruechurch.info.

Monday, June 24, 2013

Every few months I get a call from someone who either has just received a diagnosis of Down syndrome for their baby or is just finding out about TNI.

Yesterday I received a call from a mother who is just a few months along in her pregnancy and had received a prenatal diagnosis of Down syndrome for her unborn baby. I had a good, long conversation with her about what she can do for her baby.

But, some of the conversation dealt with the diagnosis, since it was still so fresh for her. She was discouraged because of the lack of support she had received and the comments to which people hinted towards abortion. She shared she had always been pro-life, so she was keeping her baby. But, I couldn’t sit here and be quiet over one of the comments she shared. I completely understand why she would be discouraged by the comments she has received.

She shared that one of her co-workers had said, "I'm so sorry! That is one of the worst things that could ever happen to you!"

*sigh*

People need to stop and think about what they are saying. This mother is in the very small percentage – 8% - of families who keep their baby after a prenatal diagnosis of Down syndrome. Yes, that’s right, 92% of babies prenatally diagnosed with Down syndrome have their hearts stopped by abortion and are thrown away as if they are not human.

People act like it’s the end of the world to have a child with Down syndrome. Really, folks, when that child is born, it is just.a.baby. That baby, has eyes, ears, a nose, a mouth, hands, feet, legs, arms, just like you and me. It’s a human. That baby wants to be held and loved by its mother as every other newborn does. That baby needs love and care. It needs its diaper changed. That newborn depends on its mother just like every other baby born does, for love, care, nourishment, protection and its voice. You or I could’ve been born with a third chromosome. That child did not choose to have a third 21st chromosome. God chose to give that child an extra chromosome. It’s time to lighten up, start loving, have compassion on that unborn life, be that baby’s voice and realize that all children are a blessing.

You know what, just because someone might take life a little slower, doesn’t justify ending that baby’s life. It can be a good thing to slow down and appreciate the small things in life more.

Sure, there are health concerns that are associated with Down syndrome. The concern for that is understandable, but does that justify snuffing out that little one’s life? To kill a helpless life that cannot speak for itself? No, it’s time to help that child and be that child’s voice, to protect and care for that baby.

Someone can end that life within their womb because of a diagnosis of a third chromosome. But, it’s not justified, it is wrong and they will be held accountable for their acts. God gave that mother a gift. It’s not a choice. It’s a life. It’s a child. It’s a helpless baby.

I look at my brother and see what a huge blessing he has been from the moment he was born. I cannot even begin to fathom how someone could be so cold to kill (abort) such a helpless life, who had nothing to do with having an extra chromosome. Society has promoted that it’s the “mother’s choice”, but no one seems to remember that there is a baby inside of that womb who is a person. Where is that baby’s choice?

Instead of falling into the 92% of families who abort their babies who are prenatally diagnosed with Down Syndrome, I beg any expectant mothers who run across this blog, to protect that baby who is prenatally diagnosed and be a voice for that baby.

Let's celebrate this baby, who just happens to have a diagnosis of Down syndrome, and sing its birthday song when it's born. Instead of being another birthday song that is unsung, because a child was thrown away, torn up and had its heart stopped. Simply because someone didn’t have the love to care for a child who was a little different.

As I sit here and type through the tears, I realize this post may upset some people, but I will not apologize for speaking up for those babies whose hearts are stopped at the hand of violence, and who suffer for wrong, cloaked in the name of ‘choice.’ I’m not afraid to speak up for the unborn babies who have their bloodshed and are torn up by such a shameful, heartless act. Because it’s not her choice, therefore I will not keep silent.

Introduction: Trisomy 21 or Down Syndrome (DS) patients have a predisposition for Congenital Hypothyroidism which can aggravate their mental status.

Hypothesis: The presence of three copy of Dyrk1a gene, localized in chromosome 21 in Humans, is responsible for a thyroidal dysgenesis.

Our aim is to understand the molecular mechanisms underlying this condition.Methods: The transgenic Dyrk1a (TgDyrk1a) mouse, our DS murine model, contains three copies of the Dyrk1a gene and was obtained through electroporation of a Bacterial Artificial Chromosome containing the entire gene with its own regulatory sequences. We studied their thyroidal phenotype in young adults (8–13 weeks old) by histology, immunohistochemistry and blood T4 hormonal dosages, reflecting the thyroidal function. We compared the thyroidal molecular phenotype of the TgDyrk1a and wild type mice: RNA levels of molecules involved in the thyroidogenesis were studied by qRT-PCR at different embryonic stages.

Results: The average surface of thyroidal follicles in young adult TgDyrk1a mice is smaller (TgDyrk1a: 2164 μm2 versus wild type: 1420 μm2; P=0.005; n=6). They presented also a lower plasmatic T4 (TgDyrk1a: 2.4 ng/ml versus wild type: 3.7 ng/ml; P=0.019; n=14). The overexpression of Dyrk1a in the thyroids leads to an elevation of RNA level expression of Nkx2-1, Foxe1, Thyroperoxidase and Thyroglobulin, involved in thyroidogenesis, at E13.5 and E17.5.Conclusion: Our first results show an abnormal thyroid function and histology in young adult TgDyrk1a mice and an overexpression of thyroidal developmental molecules. To further understand the molecular mechanism linking Dyrk1a overexpression to altered thyroid folliculogenesis and function we are studying some candidates as direct targets of Dyrk1a using thyroidal cell lines.Declaration of interest: The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research project.

Funding: This work was supported. Supported by Sandoz SAS, EDF and the Fondation Lejeune. T4 dosage courtesy of Pr S Refetoff, Chicago.

Thursday, June 20, 2013

Remember the study that prompted my big post on EGCG a few months back? The one that showed EGCG can actually create Mitochondrial Biogenesis in individuals with Down syndrome? Yeah, that was huge news!

A critical role for mitochondrial dysfunction has been
proposed in the pathogenesis of Down's syndrome (DS), a human
multifactorial disorder caused by trisomy of chromosome 21, associated
with mental retardation and early neurodegeneration. Previous studies
from our group demonstrated in DS cells a decreased capacity of the
mitochondrial ATP production system and overproduction of reactive
oxygen species (ROS) in mitochondria. In this study we have tested the
potential of epigallocatechin-3-gallate (EGCG) – a natural polyphenol
component of green tea – to counteract the mitochondrial energy deficit
found in DS cells. We found that EGCG, incubated with cultured
lymphoblasts and fibroblasts from DS subjects, rescued mitochondrial
complex I and ATP synthase catalytic activities, restored oxidative
phosphorylation efficiency and counteracted oxidative stress. These
effects were associated with EGCG-induced promotion of PKA activity,
related to increased cellular levels of cAMP and PKA-dependent
phosphorylation of the NDUFS4 subunit of complex I. In addition, EGCG
strongly promoted mitochondrial biogenesis in DS cells, as associated
with increase in Sirt1-dependent PGC-1α deacetylation, NRF-1 and T-FAM
protein levels and mitochondrial DNA content.

In
conclusion, this study shows that EGCG is a promoting effector of
oxidative phosphorylation and mitochondrial biogenesis in DS cells,
acting through modulation of the cAMP/PKA- and sirtuin-dependent
pathways. EGCG treatment promises thus to be a therapeutic approach to
counteract mitochondrial energy deficit and oxidative stress in DS.

Well, we have the full text in PDF format of that study, which is always a helpful resource to have. You can download the PDF here.

Tuesday, June 18, 2013

I just found out that
a second and larger clinical trial has started in Spain. The dosage remains the
same as in the pilot study, but this time the duration was set for 12 instead
of only 3 months, and there are 100 participants ages 14 to 29yrs. First results are expected for December 2013.

The name of the clinical trial is:
Normalization of dyrk1A and
APP Function as an Approach to Improve Cognitive Performance and
Decelerate AD Progression in DS Subjects: Epigallocatechin Gallate as
Therapeutic Tool.

This is the brief summary and the goal of the study:

Epigallocatechin-3-gallate (EGCG), the major catechin in green tea, is
postulated to modulate dual specificity
tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) and amyloid beta
precursor protein (APP) gene overexpression in the brains of Down
syndrome mouse models. The clinical study is aimed at demonstrating that
normalization of Dyrk1A and APP functions is a therapeutic approach to
improve cognitive performance and decelerate AD (Alzheimer's disease)
like progression.

Monday, June 17, 2013

MyBlogSpark provided us with a baking gift set, complete with a pan, rolling pin, a couple rubber utensils and a timer to be able to do a blog post on Betty Crocker's Gluten Free Baking Mixes.

So, we went out and picked up a Betty Crocker Gluten Free Pancake and Baking Mix. This mix is your all-in-one gluten free flour combination and it works great. We found a regular cake recipe and changed it up some to fit what we needed and so that it would be gluten-free.

Smart moms already trust the great taste of Betty Crocker Gluten Free Brownie, Cookie and Cake mixes that the whole family can enjoy, and now beginner-to-expert bakers can use mixes or create from scratch delicious recipes year-round!

So why are Gluten Free moms choosing Betty Crocker?

• Taste — Our consumers rave about the great taste of our Gluten Free products. Check out some of the great comments here.• Shareable — You can make one dessert for the whole family.• Normalcy — You can feel "normal again" baking for your family just like before you went gluten free.

The cake we chose to make was a spice cake. Here's the recipe below. Enjoy! (Remember you can always click the "Printer Friendly" button at the bottom of each blog post to print the recipe out)

Down Syndrome (DS) is a genetic disorder that affects ~1 in 700 live births, caused by trisomy of human chromosome 21 (Hsa21), and results in cognitive impairment, craniofacial abnormalities, low muscle tone, and skeletal deficiencies. To study these phenotypes, we utilized the Ts65Dn mouse model, which contains three copies of approximately half the orthologous found on Hsa21 and exhibits similar phenotypes as found in humans with DS. Individuals with DS and Ts65Dn mice have deficits in bone mineral density (BMD), architecture, and bone strength. Over-expression of DYRK1A, a serine-threonine kinase encoded on Hsa21, has been linked to deficiencies in DS bone homeostasis. Epigallocatechin-3- gallate (EGCG), an aromatic polyphenol found in high concentrations in green tea, is a known inhibitor of Dyrk1a activity. Normalization of Dyrk1a activity by EGCG may have the potential to regulate bone homeostasis and increase BMD and bone strength in individuals with DS. In this study, we hypothesized that EGCG obtained from different sources would have differential effects in correcting bone deficits associated with DS. To test our hypothesis, we performed on EGCG and related compounds from different sources. The LC-MS analysis determined the amount of EGCG and the degradation in our stock solution. Next, we treated three-week- old Ts65Dn and control male mice with EGCG for three weeks. At six weeks of age, mice were sacrificed. DXA and micro CT analysis were performed on the femurs and skulls of the mice to assess trabecular and cortical bone structure and BMD. Our results indicate the ability of EGCG to ameliorate skeletal deficiencies and compared pure EGCG with EGCG purchased from commercial vendors in correcting skeletal deficits associated with DS.