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[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

Over the past several years, we have seen a number of cases in which this prolapsed fat was confused pathologically with a neoplasm of adipocytic lineage, specifically pleomorphic lipoma and atypical lipomatous neoplasm (well-differentiated liposarcoma).

We conclude that subconjunctival herniated orbital fat commonly contains multinucleated floretlike giant cells, fibrous septae, and Lochkern cells, features that may result in diagnostic confusion with pleomorphic lipoma and atypical lipomatous neoplasms.

Importantly, specific diagnostic features, such as aggregates of bland spindled cells associated with wiry collagen, as seen in pleomorphic lipoma, and enlarged hyperchromatic cells within fibrous septae, as in atypical lipomatous neoplasms, are entirely absent in herniated orbital fat.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

The differential diagnosis of soft tissue tumours poses a considerable challenge for pathologists, especially adipocytic tumours, as these may show considerable overlap in clinical presentation and morphological features with many other mesenchymal neoplasms.

Benign and malignant adipocytic tumours showed strong expression of PIM-1 while the non-adipocytic tumours were either negative or showed only weak staining for the protein.

Our results indicate that the expression of PIM-1 in adipose tissue may be a useful marker of adipocytic differentiation, in particular if the staining is both of high intensity and present in a unique, vacuolar pattern.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

Histopathologic examination of the resected specimen revealed a multilobulated, tan-yellow, variegated tumor with a rubbery consistency that was separated by thick fibrous septa with interspersed collections of foamy histiocytes.

This report highlights recent advances that may help confirm the diagnosis and explain the differential diagnosis of this rare tumor.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Giant hypopharyngeal atypical lipomatoustumor.

Microscopically, they display an admixture of fibrovascular and adipose tissue that is coated by unremarkable squamous mucosa.

Here, we report a case that had scattered hyperchromatic cells and lipoblasts within the adipose tissue component.

In other anatomic sites similar appearing lesions have been interpreted as pedunculated liposarcomas/atypical lipomatous tumors that are more prone to local recurrences than classic giant fibrovascular polyps.

To confirm our suspicion of liposarcomatous differentiation, we performed immunohistochemistry for MDM2 and p53, 2 markers that are known to be negative in benignlipomatous lesions and positive in well-differentiated liposarcomas/atypical lipomatous tumors.

The scattered atypical hyperchromatic cells and the lipoblasts both exhibited strong nuclear staining for both markers and supported the diagnosis of pedunculated giant hypopharyngeal atypical lipomatoustumor.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

BACKGROUND: This study researched the electric impedance properties of breast tissue and demonstrated the different characteristic of electrical impedance scanning (EIS) images.

METHODS: The impedance character of 40 malignant tumors, 34 benign tumors and some normal breast tissue from 69 patients undergoing breast surgery was examined by EIS in vivo measurement and mammography screening, with a series of frequencies set between 100 Hz - 100 kHz in the ex vivo spectroscopy measurement.

Of the 30 patients with 34 benign tumors there were almost no specific abnormality shown in the EIS results.

Atypical lipomatoustumor/well-differentiated liposarcomas and dedifferentiated liposarcomas are characterized by the amplification of MDM2 and CDK4 genes.

To evaluate the accuracy of fluorescence in situ hybridization (FISH) analysis in the differential diagnosis ofadipose tissue tumors, we investigated MDM2-CDK4 status by FISH, real-time polymerase chain reaction (PCR) [quantitative PCR (Q-PCR)] and immunohistochemistry (IHC) in a series of 200 adipose tumors.

First, we evaluated MDM2-CDK4 amplification and expression in a series of 94 well-defined adipose tissue tumors.

We then used the same techniques as complementary diagnostic tools in a series of 106 adipose and soft tissue tumors of unclear diagnosis to distinguish between (i) lipomas and atypical lipomatoustumor/well-differentiated liposarcomas, (ii) malignant undifferentiated tumors and dedifferentiated liposarcomas, and (iii) a variety of benign tumors and liposarcomas.

When tumor cells represented a minor component of the tumor tissue, such as with inflammatory tumors, FISH was more powerful than Q-PCR by allowing visualization of individual cells.

In conclusion, we recommend that the evaluation of MDM2-CDK4 amplification using FISH or Q-PCR be used to supplement IHC analysis when diagnosis ofadipose tissue tumors is not possible based on clinical and histologic information alone.

15. Chien AL, Song DH, Stein SL: Two young girls with lipoblastoma and a review of the literature.Pediatr Dermatol; 2006 Mar-Apr;23(2):152-6[Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

Lipoblastoma is an uncommon, benign tumor of embryonic adipose tissue that occurs predominantly in the pediatric population.

Biopsy of the lesion is standard for diagnosis, as clinical and radiologic diagnoses can be misleading.

(PMID = 16007264.001).

[ISSN] 1449-1907

[Journal-full-title] International journal of medical sciences

[ISO-abbreviation] Int J Med Sci

[Language] eng

[Publication-type] Journal Article

[Publication-country] Australia

[Other-IDs] NLM/ PMC1168877

19. Zhang F, Xie ZJ, Ge WL, Li SL, Li YN: Tensile force produced by a lipoma in the masseteric space possibly causing hyperostosis of the angle of the mandible.Med Sci Monit; 2009 Sep;15(9):CS148-50[Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

BACKGROUND: A lipoma is a benign tumor which may occur in the adipose tissue of any part of the body.

The tumor is most commonly found on the trunk and extremities.

Although it is the most common tumor of mesenchymal origin in the head and neck, its incidence is relatively rare.

Lipoma of the head and neck is usually located in subcutaneous tissue.

Atypical lipomatoustumor/well-differentiated liposarcoma (ALT-WDLPS) and dedifferentiated liposarcoma (DDLPS) may be difficult to distinguish from benign adipose tumors and from poorly differentiated sarcomas, respectively.

Most ALT-WDLPS/DDLPS expressed MDM2 (97%) and CDK4 (92%) as opposed to few benign adipose tumors (MDM2, 5%; CDK4, 2%) and a limited number of non-ALT-WDLSP/DDLPS sarcomas (MDM2, 19%; CDK4, 6%).

The sensitivity and specificity of MDM2 and CDK4 immunostainings in identifying ALT-WDLPS/DDLPS among other soft tissue tumors were 97% and 92%, and 83% and 95%, respectively.

MDM2 and CDK4 immunostainings were particularly useful to separate ALT-WDLPS from the large group of differentiated adipose tumors, and to distinguish DDLPS from poorly differentiated sarcomas.

In conclusion, MDM2 and CDK4 immunostainings, which correlate with gene amplification, are helpful adjuncts to differentiate ALT-WDLPS from benign adipose tumors and to separate DDLPS from poorly differentiated sarcomas.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Adipocytes as immune cells: differential expression of TWEAK, BAFF, and APRIL and their receptors (Fn14, BAFF-R, TACI, and BCMA) at different stages of normal and pathological adipose tissue development.

Adipose tissue represents a rich source of multipotent stem cells.

Our view of adipose tissue has recently changed, establishing adipocytes as new members of the immune system, as they produce a number of proinflammatory cytokines (such as IL-6 and TNFalpha and chemokines, in addition to adipokines (leptin, adiponectin, resistin) and molecules associated with the innate immune system.

In this paper, we report the differential expression of TNF-superfamily members B cell activating factor of the TNF Family (BAFF), a proliferation inducing ligand (APRIL), and TNF-like weak inducer of apoptosis (TWEAK) in immature-appearing and mature adipocytes and in benign and malignant adipose tissue-derived tumors.

We further report the existence of functional BCMA, TACI, and Fn14 receptors and their ligands BAFF, APRIL, and TWEAK on adipose tissue-derived mesenchymal cells, their interaction modifying the rate of adipogenesis.

23. Sarnat HB, Flores-Sarnat L: Embryology of the neural crest: its inductive role in the neurocutaneous syndromes.J Child Neurol; 2005 Aug;20(8):637-43[Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

After dorsal closure of the neural tube, neural crest cells separate and migrate throughout the embryo to form many structures of ectodermal origin (eg, dorsal root and autonomic ganglia, peripheral nerve sheaths) and mesodermal origin (eg, blood vessels, melanocytes, adipose tissue, membranous bone, connective tissue, most of the ocular globe).

Many defective genes in neurocutaneous syndromes have an additional function as tumor suppressors.

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(PMID = 16225807.001).

[ISSN] 0883-0738

[Journal-full-title] Journal of child neurology

[ISO-abbreviation] J. Child Neurol.

[Language] eng

[Publication-type] Journal Article; Review

[Publication-country] United States

[Number-of-references] 74

24. Kondi-Pafiti A, Grapsa D, Kairi-Vassilatou E, Kontogianni-Katsarou K, Koliopoulos C, Botsis D: Mesenchymal tumors of the uterine corpus with heterologous and hematopoietic components: a study of ten cases and review of the literature.Eur J Gynaecol Oncol; 2006;27(1):73-7[Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

OBJECTIVE: To study the histopathological features of mesenchymal tumors of the uterine corpus with heterologous and hematopoietic components, and review their histogenesis and differential diagnosis from other neoplastic and non-neoplastic lesions.

METHODS: Ten cases of mesenchymal tumors of the uterine corpus, massively infiltrated by hematopoioetic cells, or composed of other benign heterologous elements (adipose tissue in the present cases) were retrieved from the archival files of our laboratory and studied histopathologically.

RESULTS: Six of our studied cases were diagnosed as leiomyomas, two as lipoleiomyomas, one as a symplastic lipoleiomyoma, and one as an endometrial stromal tumor.

The endometrial stromal tumor was severely infiltrated by histiocytes, and was positive for vimentin, CD10, PgR and negative for actin, desmin, ER and caldesmon.

CONCLUSION: The presence of hematopoietic or heterologous elements within an otherwise bland uterine leiomyoma or endometrial stromal tumor may give rise to diagnostic difficulties.

Regularity of the tumor margins, low mitotic activity and absence of nuclear atypia or necrosis should be established for the exclusion of a malignancy.

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(PMID = 16550975.001).

[ISSN] 0392-2936

[Journal-full-title] European journal of gynaecological oncology

[ISO-abbreviation] Eur. J. Gynaecol. Oncol.

[Language] eng

[Publication-type] Comparative Study; Journal Article; Review

[Publication-country] Italy

[Number-of-references] 37

25. Nakamura N, Kudo A, Ito K, Tanaka S, Arii S: A hepatic lipoma mimicking angiomyolipoma of the liver: report of a case.Surg Today; 2009;39(9):825-8[Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

Radiological examinations (computed tomography, ultrasonography, magnetic resonance imaging) showed a well-defined mass, which was finally diagnosed to be located in the left part of the caudate lobe of the liver, containing two spotty enhanced nodules within the tumor.

The cut surface of the specimen showed an encapsulated, homogeneous, yellowish tumor consisting of mature adipose tissue, which was diagnosed as lipoma of the liver.

The two nodules within the tumor were encapsulated hemorrhage.

Therefore, the final diagnosis was lipoma of the liver, which is an extremely rare benign liver tumor.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

Lipoblastoma is an rare benign tumors of infancy of fetal adipose tissue, that usually affect infants and children less than 3 years of age.

The tumor was completely excised surgically.

The clinical diagnosis of lipoblastoma was confirmed pathologically.

This experience is illustrative for the orthopaedic surgeon, because it shows the importance to performe a complete clinical examination in all patients, to avoid the omission in the diagnosis of this pathology.

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(PMID = 17937179.001).

[ISSN] 2306-4102

[Journal-full-title] Acta ortopédica mexicana

[ISO-abbreviation] Acta Ortop Mex

[Language] spa

[Publication-type] Case Reports; English Abstract; Journal Article

[Publication-country] Mexico

31. de Moraes M, de Matos FR, de Carvalho CP, de Medeiros AM, de Souza LB: Sialolipoma in minor salivary gland: case report and review of the literature.Head Neck Pathol; 2010 Sep;4(3):249-52[Fulltext service] Download fulltext PDF of this article and others, as many as you want.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

Due to the scalloping of L3/L4 foramen with root enlargement and slow evolution (more than one year between the first symptom and surgery without clinical worsening), the initial preoperative diagnosis was L3 schwannoma.

The tumor was composed of irregular melanocytoid cells with high proliferation index (20%).

So, the final diagnosis was intradural primitive malignant melanoma.

Radiotherapy was performed on the site of the tumor.

The most common tumor with root enlargement and bony scalloping is the benign schwannoma.

Despite the above described radiological features, MRI characteristics (hyperintensity when images are T1-weighted) suggest a melanocytic tumor, a tumor with a high adipose component or an intratumoral bleeding.

Specific MRI sequences can eliminate adipose tissue tumor, but diagnosis between melanin and methemoglobin is still difficult.

According to the index of proliferation, a primitive central melanocytic lesion can be a meningeal melanocytoma (considered as benign) or a primitive malignant melanoma.

The histological features of malignant lesion with benign clinical features lead to interrogation upon the actual pathologic classification.

[Publication-type] Case Reports; English Abstract; Journal Article

[Publication-country] France

34. Ramírez GA, Spattini G, Altimira J, García B, Vilafranca M: Clinical and histopathological features of a thymolipoma in a dog.J Vet Diagn Invest; 2008 May;20(3):360-4[Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

This study presents a case of a canine thymolipoma, which is a rare, slow-growing, benign tumor of the thymus composed of mature adipose tissue and thymic tissue.

Microscopically, the mass was composed of adipose tissue with numerous cords and nests of thymic tissue without corticomedullary arrangement.

To the authors' knowledge, this is the first description of this uncommon neoplasm in a dog.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

Cellular angiofibroma is a benign mesenchymal neoplasm of female and male genital tract composed of prominent vasculature and stromal spindle cells, often with admixture of adipose tissue.

The tumor has histomorphologic similarities to angiomyofibroblastoma and spindle cell lipoma.

Herein we describe a tumor arising in the perineal region of a 60-year-old man with morphological and immunohistochemical features of cellular angiofibroma and showing cytogenetic characteristics similar to spindle cell lipoma.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

Well-differentiated liposarcoma/atypical lipomatoustumor can be difficult to differentiate from benignlipomatous tumors, especially on limited biopsy material.

Adjunctive tests for MDM2 (murine double minute 2) have proven useful in whole-tissue sections; however, their utility has not been determined within the increasingly popular core needle biopsy.

Herein, we compare the ability of MDM2 immunohistochemistry and MDM2 fluorescence in situ hybridization (FISH) to discriminate benignlipomatous tumors from well-differentiated liposarcoma on core needle biopsies.

Well-differentiated liposarcoma (n=17) and an assortment of benignlipomatous tumors (n=37), which had concurrent or previous core needle biopsies, and resection specimens were subjected to both MDM2 immunohistochemistry and MDM2 FISH on both whole-tissue sections and corresponding core needle biopsy sections.

Percentage tumor cells positive for MDM2 by immunohistochemistry and an MDM2:CEP12 FISH ratio was calculated in each biopsy and resection specimen pair and the results were compared.

The average MDM2:CEP12 ratio was similar in the biopsy material compared with the whole-tissue sections in both well-differentiated liposarcoma and the benignlipomatoustumor group of neoplasms.

Detection of MDM2 amplification by FISH is a more sensitive and specific adjunctive test than MDM2 immunohistochemistry to differentiate well-differentiated liposarcoma from various benignlipomatous tumors, especially on limited tissue samples.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

In order to circumvent the limitations and/or bias of dietary exposure assessment tools, biomarkers of past lipid intake such as the fatty acid composition of white adipose tissue have been used.

This article presents a reappraisal of the role of the lipid profile through a comprehensive reanalysis of adipose tissue fatty acid composition obtained in patients with benign or malignant breast tumors as well as in experimental animals during dietary interventions.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title]Benign thyroid teratomas manifest painful cystic and solid composite nodules: three case reports and a review of the literature.

Benign thyroid teratomas are rare in adolescents and adults.

We report on three cases of benign thyroid teratomas that presented as painful tumors in the neck after puberty.

The tumor adjacent to the thyroid in each case showed rapid enlargement with predominant cystic lesions within several months.

Ultrasonography and computed tomography revealed few findings suggesting the origin of the tumor.

The patients subsequently underwent resection of the tumor, and microscopic examination revealed various types of tissue including pancreas, adipose, cartilage, muscle, and skin, and the cystic wall was lined by gastric, intestinal, respiratory, and stratified squamous epithelium.

The main characteristic of our cases presented the painful tumors due to the enlarged cystic formation lined by a variety of different types of epithelium, which agreed with previous cases of benign thyroid teratomas in adolescents and adults.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

Adiopcyte fatty acid binding-protein(A-FABP) is another protein found in adipose tissue;therefore, we investigated the association of A-FABP with the occurrence and prognosis of breast cancer.

In our study,200 women attending the University of Ulm for breast surgery between the years 2005 and 2007 were included;159 had histologically confirmed breast cancer; 41 had histologically confirmed benign lesions.

Serum levels ofA-FABP, leptin, and adiponectin were measured, and their relationship to body-mass-index (BMI), breast cancer, and tumor characteristics were analyzed; logistic regression model was adjusted to age, BMI, menopausal status, use of Hormone Replacement Therapy (HRT), and family history of breast cancer.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

Adipose tissue is a major endocrine and it secretes hormones termed adipokines.

This study was designed to determine the serum VEGF and adiponectin levels in patients with benign and malignant gynecological diseases and if there was a correlation between serum VEGF and adiponectin.

Diagnosis ofbenign and malignant gynaecological diseases was established by biopsy.

RESULTS: Our results were analyzed on the basis of 2 different parameters: age and benign and malignant gynecological diseases of the patient.

Only for serum VEGF levels was a significant difference observed (P = 0.004) between patients with benign and malignant gynecological diseases.

A significantly inverse correlation between serum VEGF and adiponectin levels among patients with benign and malignant gynecological diseases was found.

CONCLUSIONS: This is one of the first report on adiponectin in benign and malignant gynecological diseases.

Immunoreactive AKR1C3 was detected in epithelial and stromal components of benign lesions and ductal carcinomas in situ, and in 59.8% of epithelial and 69.6% of stromal cells in invasive breast carcinomas.

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(PMID = 16413454.001).

[ISSN] 1529-9430

[Journal-full-title] The spine journal : official journal of the North American Spine Society

[ISO-abbreviation] Spine J

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] United States

56. Kim HS, Yun KJ: Adenolipoma of the thyroid gland: report of a case with diagnosis by fine-needle aspiration cytology.Diagn Cytopathol; 2008 Apr;36(4):253-6[Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Adenolipoma of the thyroid gland: report of a case with diagnosis by fine-needle aspiration cytology.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Lipoadenofibroma of the endometrium: a rare variant of benign mullerian mixed tumor.

OBJECTIVE: Adenofibroma is a form of mixed mesodermal tumor in which epithelial and stromal components are benign, and usually arises in the endometrium of postmenopausal women.

We report a case of lipoadenofibroma of the endometrium that appeared as an intracavitary mass, which is very unusual because endometrioid adenofibroma rarely contains mature adipose tissue, only the second such case described in detail.

The endometrial polypoid mass was found to be a lipoadenofibroma composed predominantly of collagenated fibrous stroma populated by cystically dilated and occasionally crowded glands lined with proliferative endometrium, intermingled with abundant mature adipose tissue.

CONCLUSION: We suggest that uterine adenofibromas with lipomatous areas belong to the family of mixed tumor of Mullerian origin.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

OBJECTIVE: To assess how optical scatter properties in breast tissue, as measured by phase contrast microscopy and interpreted pathophysiologically, might be exploited as a diagnostic tool to differentiate cancer from benign tissue.

RESULTS: Stroma demonstrated significantly higher scatter intensity than did epithelium, with lower scattering in tumor-associated stroma as compared with normal or benign-associated stroma.

Measures were comparable for invasive and noninvasive malignant tumors but were higher than those found in benign tumors and were lowest in adipose tissue.

CONCLUSION: Significant differences were found in scatter coefficient properties of epithelium and stroma across diagnostic categories of breast tissue, particularly between benign and malignant-associated stroma.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

Pulmonary hamartoma is a benignneoplasm that rarely recurs or undergoes malignant transformation.

Herein, we report a 48-year-old woman with a history of an incomplete excised nonchondroid pulmonary hamartoma presenting as an indolent tumor recurrence.

Excision of the tumor revealed a well-differentiated liposarcoma arising from the hamartomatous component.

These findings suggest that the formation of the 12q14-q15 chromosome amplicon, the characteristic cytogenetic finding of well-differentiated liposarcomas and the structural genomic component of the supernumerary ring and giant rod chromosomes, occurred before the morphologic changes characteristic of these malignant adipose tissue tumors and likely represents a very early molecular event in their development.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

A method for image reconstruction of the effective size and number density of scattering particles is discussed within the context of interpreting near-infrared (NIR) tomography images of breast tissue.

Then the method was used in NIR patient images, and it indicates that for a cancer tumor, the effective scatterer size is smaller than the background breast values and the effective number density is higher.

In contrast, for benign tumor patients, there is not a significant difference in effective scatterer size or number density between tumor and normal tissues.

The method was used to interpret magnetic resonance imaging-coupled NIR images of adipose and fibroglandular tissues, and it indicated that the fibroglandular tissue has smaller effective scatterer size and larger effective number density than the adipose tissue does.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

Cytogenetics is of considerable value when diagnosing lipomatous tumours, as different tumour types have different more or less specific chromosomal abnormalities.

One such entity is lipoblastoma, which is a benignlipomatous tumour that often exhibits rearrangements of chromosome bands 8q11-13, and the gene PLAG1 has been implicated as the target of these chromosomal changes.

All lipomatous tumours karyotyped at the Norwegian Radium Hospital were reviewed, looking for rearrangements of 8q11-13.

The findings raise the question as to what extent the diagnosis lipoblastoma should be based on histopathological or cytogenetic/molecular data or a combination thereof.

When karyotypic information from this series was combined with available literature data, it was found that the sensitivity of 8q11-13 rearrangements for diagnosing lipoblastomas when found in a lipomatous tumour was 77% and that the corresponding specificity was 98%.

The validity of these calculations of the diagnostic information provided by the cytogenetic findings is, of course, totally dependent on the morphological diagnosis made in each case.

Regardless of what the precise phenotypic diagnosis was, it is suggested that lipomatous tumours with 8q11-13 rearrangement constitute a distinct pathogenetic entity.

When selective therapies tailor-made against the specific pathogenetic rearrangement become available, it will become mandatory to pay more attention to the genetic constitution of the tumour cells than to their phenotypic appearance.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Comparison of some trace elements concentration in blood, tumor free breast and tumor tissues of women with benign and malignant breast lesions: an Indian study.

Fifty women residing in and around New Delhi, India and identified to have benign (25 nos.) and malignant (25 nos.) breast lesions were studied for the first time to access the association between environmental exposure to lead and risk of breast cancer and to determine the potential of changes in trace elements concentration as a diagnostic marker and/or its etiological involvement in the disease.

Blood, tumor tissue and breast adipose tissue from tumor free area from each patient of the two groups, collected at the time of lumpectomy or mastectomy (only blood sample was collected from disease free control group), were analyzed to determine the concentration of Pb, Zn, Cu, Fe and Ca using Atomic Absorption Spectrometry.

Blood lead was significantly higher in malignant cases than in those of benign and control (p<0.05 each).

Lead level was also higher in tumor tissue when compared with their respective normal tumor free breast tissue, though non-significant, in both benign and malignant cases.

Interestingly, Zn, Fe, and Ca levels were higher in blood of malignant cases than in those of their benign counterparts.

Furthermore, these metals were also higher in tumor of malignant and benign cases as compared to normal tumor free breast tissue, many of them statistically significant (p<0.05/0.01/0.001).

However, Cu level was insignificantly lower in the blood and tumor tissue of malignant cases when compared with their benign counterparts while it was significantly higher (p<0.05) in tumor of benign cases when compared with those of their respective normal tumor free breast tissue.

There were statistically significant correlations between lead and trace element levels only in normal tumor free breast tissue of benign and malignant cases (r=0.41-0.73; p<0.05-0.001) but neither in blood nor tumor tissue of the two groups.

Further, modulation of trace elements level in both benign and malignant breast diseases patients may be of potential to be used as diagnostic marker of the disease process and its possible relationship etiologically.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

Benign nerve sheath tumors of soft tissue can occasionally adopt unusual or unfamiliar morphologic appearances that may introduce difficulties for diagnosis, such as multinucleation, bizarre nuclei, intranuclear vacuoles, and other degenerative changes.

Tumor cells adopting a signet-ring or lipoblast-like configuration, however, are mostly associated with epithelial malignancies, liposarcoma and melanoma, and have been only rarely observed in spindle cell tumors of soft tissue.

[Title]Lipomatous variant of angiomyofibroblastoma: report of two cases and review of the literature.

Some cases contain scattered mature adipocytes, but the lipomatous variant in which mature adipose tissue is prominent or striking is rare.

We report two more such cases that were composed of 70 to 80% and 30 to 40% adipose tissue, respectively.

Immunohistochemical analysis showed that the tumor cells were positive for estrogen receptor, progesterone receptor, vimentin, and Bcl-2, and negative for cytokeratin AE1/1, EMA, and CD117.

Tumor cells in the first case were positive for CD34 but not desmin and muscle-specific actin.

The opposite expression profile of these three markers was observed in tumor cells in the second case: positive for desmin and muscle-specific actin and negative for CD34.

Rare cells were positive for S-100 in adipose-rich areas in the first case.

Our findings indicate that the tumor cells in the lipomatous variant have similar immunoprofile to those of usual AMF and support the concept that the lipomatous variant probably represents an extreme end of a wide spectrum of differentiation in AMF.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] [Report of a spindle cell myoepithelialioma of the minor salivary glands with extensive lipomatous component].

Myoepitheliomas of the salivary glands are rare benign tumors composed of spindle-shaped myoepithelial cells, but may show plasmacytoid, epitheloid and clear cell-types that principally exhibit myoepithelial but not ductal differentiation.

Lipomatosis in the form of isolated small islands or scattered single lipocytes, is quite uncommon, and a large amount of adipose tissue in a pleomorphic adenoma and myoepithelioma is a rarity and only described in major salivary glands.

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(PMID = 15940575.001).

[ISSN] 0935-8943

[Journal-full-title] Laryngo- rhino- otologie

[ISO-abbreviation] Laryngorhinootologie

[Language] ger

[Publication-type] Case Reports; English Abstract; Journal Article

[Publication-country] Germany

[Chemical-registry-number] 0 / Biomarkers, Tumor

75. Yong M, Raza AS, Greaves TS, Cobb CJ: Fine-needle aspiration of a pleomorphic lipoma of the head and neck: a case report.Diagn Cytopathol; 2005 Feb;32(2):110-3[Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

Pleomorphic lipoma is a rare soft-tissue tumor, most commonly seen in the head and neck regions of middle-aged men.

Aspiration of the mass showed a hypocellular specimen with atypical large and floret cells with fragments of mature fibroadipose tissue in the background.

Based on the clinical and cytomorphological findings, a diagnosis of pleomorphic lipoma was suggested, and it was confirmed on excision.

This case highlights the need to be aware of unusual benign lesions that may arise in the head and neck region.

Knowledge of these benign lesions will help in making the correct cytological diagnosis when these lesions are sampled by FNA.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

The high mobility group A (HMGA2) gene encodes a protein that alters chromatin structure and regulates the transcription of many genes; it is implicated in both benign and malignant neoplasias, but its rearrangements are a feature of development of several mesenchymal tumors.

A nuclear immunostaining was detected in 86% of conventional and intramuscular lipomas, in 86% of well-differentiated liposarcomas and in 67% of dedifferentiated liposarcomas, as opposed to 16% of other benign adipose tumors and to 15% of non-well-differentiated liposarcoma/dedifferentiated liposarcoma sarcomas.

Among benign mesenchymal tumors and lesions, it was detected in 90% of nodular fasciitis and in 88% of benign fibrous histiocytomas with respective specificities of 85 and 100%, and in 90% of aggressive angiomyxoma, contrary to other vulvovaginal tumor types, which expressed HMGA2 only rarely.

The normal adipose tissue was always negative for HMGA2.

Although not specific, immunohistochemical detection of the HMGA2 protein is helpful for the distinction of normal adipose tissue from well-differentiated lesions, particularly on biopsy or on re-excision.

It is less sensitive than MDM2/CDK4 for dedifferentiated liposarcomas diagnosis, but it appears more specific to distinguish dedifferentiated liposarcomas from other poorly differentiated sarcomas.

Finally, and may be more importantly, HMGA2 is useful for the diagnosis of benign fibrous histiocytoma, nodular fasciitis and vulvovaginal benign mesenchymal tumors.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

Retroperitoneal lesions represent a broad, diverse collection of entities; when they contain fat, the differential diagnosis, which ranges from benign to fully malignant lesions, substantially narrows.

Hibernoma is a rare benign soft-tissue tumor composed of brown fat.

Teratomas are neoplasms that originate in pluripotent cells--benign or malignant germ cells--that give rise to a wide spectrum of mature or immature tissues that are foreign to the location in which they arise and which demonstrate varying amounts of organ formation.

(PMID = 15197561.001).

[ISSN] 0937-4477

[Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

The tumor was successfully removed en bloc through a median sternotomy.

We emphasize the importance of considering mediastinal tumors as a differential diagnosis in patients with progressive dyspnea without any obvious cause and chest radiograph showing enlarged cardiac silhouette.

[MeSH-major] Lipoma / diagnosis. Mediastinal Neoplasms / diagnosis

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(PMID = 19782275.001).

[ISSN] 1876-4738

[Journal-full-title] Journal of cardiology

[ISO-abbreviation] J Cardiol

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] Japan

87. Leuschner I: [Lipofibromatosis in a 6-year-old girl: a case report].Pathologe; 2010 Mar;31(2):150-2[Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

Lipofibromatosis is a typical soft tissue lesion of childhood which is most likely underdiagnosed.

The case of a 6-year-old girl with a palmar tumor is presented.

The lesion showed a typical fascicular growth patter into the fatty tissue.

(PMID = 20076960.001).

[ISSN] 1432-1963

[Journal-full-title] Der Pathologe

[ISO-abbreviation] Pathologe

[Language] ger

[Publication-type] Case Reports; English Abstract; Journal Article

[Publication-country] Germany

88. Oishi K, Fukuda S, Sakimoto H, Eto T, Takahashi M, Nishida T: Angiomyolipoma of the colon: report of a case.Surg Today; 2009;39(11):998-1001[Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

Angiomyolipomas are benign mesenchymal tumors mostly arising from the kidney.

Here we report the findings of a 51-year-old man who presented with a submucosal tumor covered with normal mucosa and hemorrhage in the descending colon.

A histopathological examination showed that the tumor of 5.7 cm in diameter included smooth muscle (spindle cell type), mature adipose tissue, and vessels, and therefore a diagnosis of angiomyolipoma was made.

When colonoscopy shows a submucosal tumor of the colon with hemorrhage, angiomyolipoma should be considered.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

Parosteal lipoma is an extremely rare benign tumor that is composed mainly of mature adipose tissue, and it has an intimate relationship to the underlying periosteal bone.

Although parosteal lipoma is asymptomatic, motor and sensory function deficits have been reported that were caused by the tumor compressing the neuromuscular bundles in the proximal forearm and the sciatic nerve.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

Lipoma is the most common soft-tissue tumor, with a wide spectrum of clinical presentations and imaging appearances.

Several subtypes are described, ranging from lesions entirely composed of mature adipose tissue to tumors intimately associated with nonadipose tissue, to those composed of brown fat.

The imaging appearance of these fatty masses is frequently sufficiently characteristic to allow a specific diagnosis.

However, in other cases, although a specific diagnosis is not achievable, a meaningful limited differential diagnosis can be established.

The purpose of this manuscript is to review the spectrum of benign fatty tumors highlighting the current classification system, clinical presentation and behavior, spectrum of imaging appearances, and treatment.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

Our objective is to develop an optically based technology which can differentiate benign from malignant breast tissues intraoperatively through differences in tissue composition factors.

Optical images are transformed into tissue composition maps with parameters of total hemoglobin concentration, b-carotene concentration and scattering.

Within 34 specimens with pathologically confirmed positive margins, the ratio map of b-carotene/scattering showed the most significant difference reflecting a decrease in adipose and an increase in cell density within malignant margins (p=.002).

CONCLUSIONS: We present a novel optical spectral imaging device that provides a rapid, non-destructive assay of the tissue composition of breast tumor margins.