Application Information: DR6 antibody [Luke-1]

FACS: Use at a concentration of 1 μg/ml. Optimal dilutions/concentrations should be determined by the end user.

Concentration

1
mg/ml
(Please refer to the vial label for the specific concentration)

Purification

>95% by SDS-PAGE

Purification Note

Purified from concentrated hybridoma tissue culture supernatant.

Specifications: DR6 antibody [Luke-1]

Full Name

tumor necrosis factor receptor superfamily, member 21

Product Description

Rat monoclonal [Luke-1] to DR6

Background

Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNFR1 and Fas. Several novel death receptors including DR3, DR4, and DR5 were recently identified. A new death domain containing receptor in the TNFR family was cloned recently and termed DR6 for death receptor 6. Like TNFR1, DR6 interacts with death domain containing adapter molecule TRADD. Overexpression of DR6 induces apoptosis and activates NF-kB and JNK. DR6 is widely expressed inhuman tissues and cell lines. The ligand for DR6 hasnot been identified.