Vitamin K2 is not a single compound – it consists of a group of essential fat-soluble vitamins. They differ in the saturation and number of attached carbon-hydrogen atomes in the sidechain, called “isoprenoid residues.” These differences are especially pronounced in the vitamin K2 group, which includes menaquinones with different lengths of the side chain. The length is marked in the name of the particular menaquinone chain (ex: MK-4 means 4 isoprenoid resides are attached to the main ring), and the length influences their abilities to reach different tissues within the body. In other words, the longer the side chain, the better it is absorbed and longer it remains in the blood. Seebio can provide a full range of vitamin K2 products (MK-3, MK-4, MK-5, MK-6, MK-7), natural, all-trans, can meet the needs of different customers.

Natural Vitamin K2, All – trans Series

Name

Vitamin K2,Menaquinone

Product information

Abbreviation

Product name

Isoprenoid residues

CAS No.

Molecular formula

Molecular weight

MK-3

Vitamin K2(15)

3

N/A

C26H32O2

376.54

MK-4

Vitamin K2(20)

4

863-61-6

C31H40O2

444.65

MK-5

Vitamin K2(25)

5

N/A

C36H48O2

512.78

MK-6

Vitamin K2(30)

6

N/A

C41H56O2

580.89

MK-7

Vitamin K2(35)

7

27670-94-6

C46H64O2

649.0

Based on the study and practice of more than ten years, vitamin K2 (K2 Vitamin) series has developed two formulations: powder and oil.

Vitamin k2 is essential for the carboxylation of glutamate residues in certain proteins, to give carboxyglutamate. This modification allows the protein to bind calcium, an essential event in the blood clotting cascade.VK2 helps to form osteocalcin, a specific protein which is adept in calcium binding. VK2 can increase bone density to prevent fracture.

2.Curing haemorrhage caused by VK2 deficiency

Vitamin K2 plays an important role in promoting thrombin generation, accelerating blood cycle and managing clotting time. It is a common coagulant used in surgeries and first aids.

Scientists in Osaka City University in Japan did a research on vitamin k2 preventing the development of hepatocirrhosis and the result shows that vitamin k2 can prevent hepatocirrhosis to develop to liver cancer.

4.Positively influence the cardiovascular system

Healthy arterial tissues have shown to contain 100 times more Vitamin K2 than unhealthy arteries, and the amount of calcium in the arteries is a risk factor for cardiovascular health.The Rotterdam Study (2004) shows that high dietary intake of Vitamin K2 – but not vitamin K1 – has a strong protective effect on cardiovascular health.

5.Anti-inflammation

Further research has demonstrated vitamin K2's anti-inflammatory action.

As the body ages, levels of the inflammation-promoting cytokine interleukin-6 (IL-6) increase. Once IL-6 becomes out of balance with the other cytokines, inflammation accelerates. It has been observed that people with arthritis, Alzheimer's disease, and atherosclerosis have higher levels of IL-6. In a study done by the National Research Institute in Italy, it was shown that subjects with the highest levels of IL-6 were almost twice as likely to develop mobility-related disabilities.

6.Diabetes

The second highest concentration of vitamin K2 in the body is in the pancreas, which plays a major role in blood sugar and insulin regulation. In animal studies, Japanese researchers found that when they induced vitamin K2 deficiency, the test animals developed Type II diabetes.

7.Antioxidants

Research has indicated that vitamin K2 has antioxidant activity comparable to vitamin E and CoQ10. Animal studies have demonstrated complete hepatic (liver) protection from induced oxidative stress using vitamin K, and was found to be 80% as effective as vitamin E in preventing oxidation.

8.Alzheimer

About 25% of the population have a genetic predisposition for developing Alzheimer's disease - they carry the E4 form of the lipoprotein apoE. Interestingly, people who carry this gene have been found to have low levels of vitamin K2. Calcification and the development of lesions in blood vessels that feed the brain tissues are believed to be a component of Alzheimer's development. Further research may reveal high-dose vitamin K2 therapy to be preventive.

Products list of vitamin K2

lNatural Vitamin K2

Art.No.

Product name

Purity

Package

ACF0054A

Menaquinone-3(MK-3)

0.5%

1Kg、5Kg、25Kg

ACF0054B

1.0%

1Kg、5Kg、25Kg

ACF0057A

Menaquinone-4(MK-4)

0.5%

1Kg、5Kg、25Kg

ACF0057B

1.0%

1Kg、5Kg、25Kg

ACF0055A

Menaquinone-5(MK-5)

0.5%

1Kg、5Kg、25Kg

ACF0055B

1.0%

1Kg、5Kg、25Kg

ACF0056A

Menaquinone-6 (MK-6)

0.5%

1Kg、5Kg、25Kg

ACF0056B

1.0%

1Kg、5Kg、25Kg

ACF0058A

Menaquinone-7MK-7)

0.5%

1Kg、5Kg、25Kg

ACF0058B

1.0%

1Kg、5Kg、25Kg

Seebio also provide the high purity, synthetic vitamin K2.

Art.No.

Product name

Purity

Package

DCF0004F

Menaquinone-4(MK-4)

95%, oil

1Kg

DCF0004E

98%, powder

1Kg

ACF0003AN

Menaquinone-7(MK-7)

98%, powder

1Kg

DCF0005A

Menaquinone-9(MK-9)

98%, powder

1Kg

Vitamins K2 has been widely used in the prevention of osteoporosis, dietary supplements, food and liver cirrhosis research and biochemical research.Seebio® is one of the few top global manufacturer of anti-osteoporosis vitamin K2 , which earns a good reputation at home and abroad.