Rajan (born 1951) and Sajan (born 1956) Mishra were born and brought up in Varanasi. They received their initial musical training from their grandfather's brother, Bade Ram Das Ji Mishra, and also their father, Hanuman Prasad Mishra, and from their uncle, sarangi virtuoso, Gopal Prasad Mishra, and started performing while they were still in their teens.[5] They moved to Ramesh Nagar in Delhi, in 1977, where they continue to live.[6]

Rajan and Sajan Mishra are part of a 300-year-old lineage of khyal singing of the Banaras gharana, the Mishra brothers have been performing to audiences all over Indian and the world for many years.

They were both accountants in a small shop when they gave a performance in the presences of Satguru Jagjit Singh. The Satguru, realizing their talent, offered to pay double their living wages in exchange for them to put in more time to practice their vocals. The rest was history and they gave their first concert abroad, was in Sri lanka in 1978, and soon they went on to perform in many countries across the world including, Germany, France, Switzerland, Austria, USA, UK, The Netherlands, USSR, Singapore, Qatar, Bangladesh and Muscat.[7][8]