Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

Applications

Specificity and Use

Specificity:

Reacts with PGH synthase-1 from sheep, human and most other mammalian species, except mouse. Cross-reactivity with recombinant PGHS-2 is negligible at the recommended dilution.

Usage:

Suitable for use in Western Blot. A dilution of 1:1000 for Western blots will detect PGHS-1 from most mammalian species (except mice). For tissues that express low levels of PGHS-1 it may be necessary to isolate microsomes and/or concentrate PGHS by immunoprecipitation prior to analysis on Western blots. Optimum dilutions to be determined by researcher.

Description: Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gastric epithelial cells, it is a key step in the generation of prostaglandins, such as prostaglandin E2 (PGE2), which plays an important role in cytoprotection.