Objective To evaluate short term outcome of intravenous drip of mecobalamin in the conservative treatment of lumbar disc herniation.Methods In 124 cases with lumbar disc herniation,62 received short term intravenous drip of mecobalamin,and the other 62 cases received intravenous methylprednisolone.VAS pain scale and Lasegue score was used to record the degree of the patients′ radicular pain before the treatment,2 hours,6 hours,1 day,3 days,6 days and 8 days after the treatment to evaluate the recovery.Investigate on the improvement rate about the symptom of radicular pain and numbness.Results The patients in the mecobalamin group got significant pain relief in the end of treatment.After drug withdrawal for 2 days,the difference of Lasegue score between the mecobalamin and methylprednisolone group was significant.The improvement rate about the subjective symptoms were both satisfactory.Conclusion Mecobalamin can relieve radicular pain and numbness of the lower limbs effectively,and make up for the deficiency of glucocorticoid treatment.Therefore,mecobalamin might have brighter future,but needs further discussion and research.