Here's how the play is billed: "Where does one script end and another life begin? At the heart of the play is The Couple, two playwrights, dealing with unimaginable loss the only way they know how — by building a fortress of words impregnable to grief. But emotions have a way of emerging through cracks in the walls, and gradually the truth slips past their defenses to uncover their very real tragedies."

Mueller's Construction of the Human Heart was nominated for the Melbourne Prize for Literature, the 2007 Awgie Award for Play of the Year and the New York New Dramatists Award.