The Use of Medical Cannabis with Other Medications: A Review of Safety and Guidelines

Question

What is the clinical evidence regarding the safety of the use of medical cannabis with other medications?

What are the evidence-based guidelines regarding the interaction of the use of medical cannabis with other medications?

Key Message

Limited data on medical cannabis and drug-drug interactions were obtained from a low quality systematic review. Nabilone may have additive depressant effects with diazepam when taken together with alcohol and codeine, and it may decrease the need for opioids, nonsteroidal anti-inflammatory drugs, tricyclic antidepressants, dexamethasone and ondansetron when used concomitantly. No evidence-based guidelines were identified.