Barbra Streisand - 'The Guilt Trip'

Pro: Where to begin? The living legend is one of the few entertainers to ever earn an EGOT - an Emmy, a Grammy, an Oscar and a Tony Award (although she has an asterix because the Tony was non-competitive). She's actually won two Oscars - one for best actress ("Funny Girl") and another for best original song ("Evergreen (Love Theme from 'A Star is Born'). She is also one of the few women ever nominated for a DGA Award for a movie ("Prince of Tides") and was the recipient of the AFI Lifetime Achievement honor in 2001.
Con: Word is the PG-rated "The Guilt Trip" is much sweeter and less raunchy than you might expect from a picture co-starring Seth Rogen, but the Anne Fletcher comedy would have to be a major surprise for anyone to take her candidacy seriously.