This study was conducted to investigate the effects of dietary influence of aspirin on growth performance, antioxidant status and mortality in the broilers subjected to cold-induced ascites. A total six hundred 1-d old male broilers (Ross, 308) were randomly allotted to four treatment groups, with five replicate pens per treatment and 30 birds each. The experimental groups were kept in a cold chamber to induce ascites and fed the basal diet supplemented with 0, 20, 40 or 80 mg of aspirin /kg diet. Results showed, aspirin had a significant effect (P< 0.05) on broiler performance so that, 80 mg group of aspirin had greater body weight gain and lower feed conversion ratio. Compared to other groups, 20 mg of aspirin significantly reduced malondialdehyde concentration and increased total antioxidant capacity with higher glutathione peroxidase activity in plasma (P