Home » METABOLISM OF THE NORMAL CARDIOVASCULAR WALL IV. EFFECT OF EPINEPHRINE AND ISOPROPYLNOREPINEPHRINE

TITLE

METABOLISM OF THE NORMAL CARDIOVASCULAR WALL IV. EFFECT OF EPINEPHRINE AND ISOPROPYLNOREPINEPHRINE

AUTHOR(S)

Ginsburg, Jean; Beaconsfield, Peter

PUB. DATE

November 1967

SOURCE

Angiology;Nov1967, Vol. 18 Issue 11, p672

SOURCE TYPE

Academic Journal

DOC. TYPE

Article

ABSTRACT

The effects of isopropylnorepinephrine and epinephrine on glucose metabolism in arterial smooth muscle were investigated in the femoral artery of the dog. Lactic acid and carbon dioxide production from labelled glucose in arterial smooth muscle fell after incubation with isopropylnorepinephrine and was not significantly changed by the addition of epinephrine. It is suggested that isopropylnorepinephrine may induce a shift of metabolic pathways arterial smooth muscle, possibly associated with changes in lipid metabolism.

The accumulation and proliferation of vascular smooth muscle cells (VSMC) within the vessel wall is an important pathogenic feature in the development of atherosclerosis. Glucose metabolism has been implicated to play an important role in this cellular mechanism. To further elucidate the role of...

Exposure to endotoxin in vivo and in vitro, as studied by the use of the isolated, vascular, smooth-muscle technique of Bohr, indicates that the direct epinephrine-constricting effect on rabbit arterial and venous vascular smooth-muscle strips is the same preceding and after endotoxin...

This study was aimed at characterizing the functional progression of the endothelial (ECs) and smooth muscle cells (SMCs) of the coronary microvasculature between youth and old age, as well as at determining the mechanisms of the observed changes on the basis of the glucose tolerance,...

Background: The cellular localization of the Î±1D-adrenergic receptor (Î±1D-AR) is controversial. Studies in heterologous cell systems have shown that this receptor is expressed in intracellular compartments. Other studies show that dimerization with other ARs promotes the cell surface...

We have earlier shown that aortic vascular smooth muscle cells (VSMC) from 12-week-old spontaneously hypertensive rats (SHR) exhibited enhanced production of superoxide anion (O2-) compared with Wistar-Kyoto (WKY) rats. This production was attenuated to control levels by losartan, an angiotensin...

Aims/hypothesis: We aimed to characterise the development of autoregulation of glucose transport in vascular endothelial cells and its relationship to 12-lipoxygenase (12-LO) expression. Methods: Bovine aortic endothelial cells were exposed to 5.5 and 23.0 mmol/l glucose for up to 48 h. The...

Aims: High glucose promotes macrophage-derived foam cell formation involved in increased influx or reduced efflux of lipids. The aim of this study is to investigate the influence of hyperglycaemia on foam cell transformation of vascular smooth muscle cells (VSMCs) and possible mechanisms...