Previous GeneCards Identifiers for CABLES1 Gene

Summaries for CABLES1 Gene

Entrez Gene Summary for CABLES1 Gene

This gene encodes a protein involved in regulation of the cell cycle through interactions with several cyclin-dependent kinases. One study (PMID: 16177568) reported aberrant splicing of transcripts from this gene which results in removal of the cyclin binding domain only in human cancer cells, and reduction in gene expression was shown in colorectal cancers (PMID: 17982127).Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

GeneCards Summary for CABLES1 Gene

CABLES1 (Cdk5 And Abl Enzyme Substrate 1) is a Protein Coding gene.
Among its related pathways are Hemostasis and Guidance Cues and Growth Cone Motility.
GO annotations related to this gene include cyclin-dependent protein serine/threonine kinase regulator activity.
An important paralog of this gene is CABLES2.

UniProtKB/Swiss-Prot for CABLES1 Gene

Cyclin-dependent kinase binding protein. Enhances cyclin-dependent kinase tyrosine phosphorylation by nonreceptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. Positively affects neuronal outgrowth. Plays a role as a regulator for p53/p73-induced cell death (By similarity).

neXtProt entry for CABLES1 Gene

Proteomics data for CABLES1 Gene at MOPED

Protein Expression for CABLES1 Gene

Post-translational modifications for CABLES1 Gene

Phosphorylated on Ser-313 by CCNE1/CDK3. Phosphorylated on serine/threonine residues by CDK5 and on tyrosine residues by ABL1. Also phosphorylated in vitro by CCNA1/CDK2, CCNE1/CDK2, CCNA1/CDK3 and CCNE1/CDK3 (By similarity).

Flow Cytometry Products

Function for CABLES1 Gene

Products:

Molecular function for CABLES1 Gene

UniProtKB/Swiss-Prot Function: Cyclin-dependent kinase binding protein. Enhances cyclin-dependent kinase tyrosine phosphorylation by nonreceptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. Positively affects neuronal outgrowth. Plays a role as a regulator for p53/p73-induced cell death (By similarity).

Localization for CABLES1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CABLES1 Gene

Nucleus. Cytoplasm. Note=Located in the cell body and proximal region of the developing axonal shaft of immature neurons. Located in axonal growth cone, but not in the distal part of the axon shaft or in dendritic growth cone of mature neurons (By similarity). {ECO:0000250}.

mRNA Expression by UniProt/SwissProt for CABLES1 Gene

Tissue specificity:Expressed in breast, pancreas, colon, head and neck (at protein level). Strongly decreased in more than half of cases of atypical endometrial hyperplasia and in more than 90% of endometrial cancers.