Cousins, who was signed away from the Redskins by the Vikings in March, was an efficient 20-for-36 passing for 244 yards and two touchdowns against the 49ers. He didn’t turn the ball over and added 36 yards on the ground in Minnesota’s 24-16 victory over San Francisco at U.S. Bank Stadium.​

The loss was 49ers quarterback Jimmy Garoppolo’s first as San Francisco’s starter. He threw three picks in the game.​

Meanwhile, Smith, Cousins' replacement under center in Washington, picked apart the Cardinals defense. He helped the Redskins take control early and finished with 255 passing yards and two scores. Smith completed 70 percent of his passes in the game while veteran running back Adrian Peterson tallied 166 total yards.

Elsewhere, the Browns snapped their 17-game losing streak but still haven’t won a game since 2016. Cleveland and the Steelers both missed field goals in overtime and their game ended in a 21-21 tie.

The Bengals spoiled Andrew Luck's return from a shoulder injury that caused him to miss all of last season. The Colts quarterback threw for 319 yards and two touchdowns but Indianapolis fell 34-23.

The Panthers held on for a 16-8 win against the Cowboys while the Broncos pulled out a narrow 27-24 victory over the Seahawks.

Injury report

Aaron Rodgers left the Packers' game against the Bears in the second quarter with an apparent leg injury after a sack, but made a surprise return to the field to start the second half.

Jaguars running back Leonard Fournette suffered a right hamstring injury during the second quarter against the Giants. He believes he’ll be able to play next week, according to a report from ESPN.

Buccaneers wide receiver DeSean Jackson left his team’s game against the Saints in the second half with a concussion. He tallied five receptions for 146 yards and two touchdowns before leaving.

Panthers tight end Greg Olsen injured his foot in the first quarter against the Cowboys and did not return. He missed eight games after breaking his foot last season.

Star Carolina linebacker Luke Kuechly also left the game against Dallas in the fourth quarter with an apparent leg injury, but later returned. He told NFL Network he was fine after the game.

49ers wideout Marquise Goodwin injured his quad in the first half against the Vikings. He was targeted once and was held without a catch in the game.

Adrian Peterson finished the Redskins game against the Cardinals with 96 yards on the ground. He passed Jim Brown for 10th on the all-time NFL rushing yards list, and also scored his 100th career rushing touchdown in the game.

Quotables

Browns coach Hue Jackson on tie against Steelers: "This is not preseason football, this is the National Football League, it's the regular season, and we have to get better. Again, I think the guys can see that we're an improved football team, but there are some areas we have to clean up and clean up fast, and we will ... We didn't finish it. A tie … a tie."

Buccaneers wide receiver Mike Evans on Ryan Fitzpatrick's five-touchdown performance: "He played phenomenal, so I hope people had him on their fantasy teams, because he went crazy today ... And he ran and made plays with his legs and his arm. Awesome game from him, one of the most complete games I've seen from a quarterback."