Sarah Silverman says work-life balance doesn't exist.

Just ask comedian and rising star actress Sarah Silverman, who tossed the ultimate anti-feminist grenade at legions of women struggling to balance career, family and friends.

“It’s a sadness for me because I love kids. I ache for kids,” Silverman confessed to Marc Maron on his “WTF” podcast on Monday. “But I love my life more. You can’t have it all; you really can’t.”

The comment came as Silverman discussed her award-nominated role in her film, “I Smile Back,” where she plays a depressed mom.

The interview got personal as Silverman, 45, confessed that she feels “regrets” and “sadnesses” about not having kid.

“I don’t have a lifestyle that’s conducive to having kids the way I want to have kids,” she said. “And I just made that choice.”

Silverman’s bleak outlook surprised some women caught in the tug-of-war between career and children who are determined to find a balance.

“That’s a silly take if you ask me,” says Denise Albert, a cohost of the Sirius XM radio show “The Moms” with Melissa Musen Gerstein.

The 41-year-old single mother of two boys says she transitioned from a career in TV news to creating her lifestyle brand because it made her happy - not because becoming a mother derailed her media aspirations in any way.

“I have a family, I have a career and I have a lot of fun,” she says. “Just because [Silverman] doesn’t think that she can do it, that doesn’t mean other people can’t do it at all.”

Lisette Sand-Freedman, owner of Shadow PR and a mother of two, argues that different women have different definitions of what “having it all” means.

Silverman scored a SAG nomination for playing a depressed mother in "I Smile Back."

(Broad Green)

Sand-Freedman admits that she’s not perfect. She may “miss a meeting here and there” and can’t spend “all day with my kids.” But she’s making it work for herself on both fronts.

“My ‘all’ may not be your ‘all,’ but I am all about my kids and I am all about my job. That’s all,” she says.

But Silverman’s struggle is real for the many women still trying to build their careers when the gender income gap is even worse for working moms than it is for their childless sisters.

For every $1 earned by a father with children under 18, mothers earn just 74.7% according to the U.S. Department of Labor Statistics. Women overall made 82.1 cents on the dollar compared to men.

No wonder so many women wait like Silverman to become mothers.

Alison Brod was married for 12 years before having her first son when she was 35. “I just couldn’t wrap my head around having a child and building my business and enjoying my life,” says the founder and CEO of Alison Brod Public Relations. “People think the longer you wait, the more ready you are when you do it, but it can be the opposite because you get so used to life without a child.”

But unlike Silverman, Brod ultimately decided she would regret not having children more than complicating her career.

“It is the greatest thing I ever did,” she says - although, “if you are with your kids, you feel guilty that you aren’t working, and vice versa.”

Long Island mom Natalie Iovino-Schoenfeld, 33, had to switch from being an operations manager at a Huntington salon to teaching evening esthetics classes so that she could care for her daughter, who’s almost 2, during the day.

“I don’t think anyone should have to give up who they are 100%, but you do make sacrifices,. That’s life,” she says. “I wouldn’t say I ‘have it all,’ but I’m very happy with the direction I'm heading.”