Alveolar Macrophage Proteomics in HIV-associated Emphysema (HIVE)

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ClinicalTrials.gov Identifier: NCT00823927

Recruitment Status
: Unknown

Verified April 2015 by Philip Diaz, The Ohio State University. Recruitment status was: Active, not recruiting

This study is being done to examine lung function changes in individuals with HIV infection and to understand why individuals with HIV have increased risk of lung damage from cigarette smoking.

Condition or disease

HIVEmphysemaHIV Infections

Detailed Description:

To delineate the natural history of HIV associated emphysema in the HAART era. To compare the alveolar macrophage proteomes from HIV-seropositive smokers with emphysema to the alveolar macrophages proteomes of both HIV+ smokers without emphysema and HIV- smokers.

examine the natural history of smoking related lung damage in patients with HIV [ Time Frame: 3 years ]

HIV-Seropositive individuals are at increased risk of developing pulmonary emphysema (1,2). With improved therapy for HIV, and increased life expectancy in this population with a high smoking prevalence, chronic obstructive pulmonary disease (COPD) may assume an increasingly important role with respect to health related quality of life and medical complications. This research will provide a unique opportunity to examine the natural history of smoking related lung damage in patients with HIV infection. In addition, this research will involve sampling of lung cells to determine if there are unique proteins present that may be related to the increased risk of emphysema in this population. This may shed important insight into how the lung responds to injury and how it repairs itself. If critical proteins can be identified, treatment strategies may eventually be developed to either decrease proteins causing injury or increase protective proteins.

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Ages Eligible for Study:

18 Years and older (Adult, Senior)

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

No

Sampling Method:

Non-Probability Sample

Study Population

community sample

Criteria

Inclusion Criteria:

Clinically stable HIV-seropositive (and HIV-seronegative) individuals

Ages 18 years and older

Female subjects on no oral contraception with a negative pregnancy test

Subjects capable of giving written consent

Exclusion Criteria:

Known medical illness that would preclude bronchoscopy/BAL (e.g. unstable angina, new cardiac arrhythmia). This only pertains to subjects involved in the bronchoscopy phase of the study.