Fit the same tumor growth model to tumor size data from two individuals who received two different treatments.

The data

Simulated tumor sizes from two patients are displayed:

patient 1 (red dots) didn't receive any treatment

patient 2 (blue dots) received a dose of 100 units every month between month 12 and month 16

The model

Simeoni et al. presented a model for tumor growth and anti-cancer effects where a transit compartment model describes the apoptosis of tumor cells attacked by a drug. Following Koch et al. (2014), this model can be rewritten with a lifespan model