I had just recommissioned my folding rig after a month of sitting idle today. Looks like it's jumping ship for now. Is a GTS 250 worth the power used?

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Better do not let a GTS 250 crunch for the WCG, because it crunches as fast as my HD 6670 at best, in despite of its raw power and electricity draw ("crunching" draw is not equal to "peak" draw though, fortunately, in case of WCG). Unless you do not mind a less than ideal power draw/output ratio I recommend to crunch on the CPU only on that system.

Hi all. Just begin crunching. Previously was doing folding. Is it essentially the same?

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F@H pretty much simulates the "folding" of proteins in human bodies, while number crunching varies more (generally) in terms of what kind of calculations are being made. It can be folding (in case of the "Human Proteome Folding" WCG subproject) but also for example an attempt to predict how certain chemicals respond to each other in certain cercumstances, or predicting future climatic circumstance (climateprediction.net, not part of WCG).

Better do not let a GTS 250 crunch for the WCG, because it crunches as fast as my HD 6670 at best, in despite of its raw power and electricity draw ("crunching" draw is not equal to "peak" draw though, fortunately, in case of WCG). Unless you do not mind a less than ideal power draw/output ratio I recommend to crunch on the CPU only on that system.

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Should I just leave my Fermis and Kepler folding and crunch CPU only then? I'm all about efficiency.

With max HCC GPU WUs (I believe about 5 WUs), my 580 can do ~30kPPD @ 875core. Not as great as AMD, but I believe its better than Kepler and it far outpaces what my i7 3770K does running 24/7 on its own @ 4.2ghz (~5kPPD). Even considering that the Fermi card will use more power, it is still a very efficient way to crunch considering the wattPD.

With max HCC GPU WUs (I believe about 5 WUs), my 580 can do ~30kPPD @ 875core. Not as great as AMD, but I believe its better than Kepler and it far outpaces what my i7 3770K does running 24/7 on its own @ 4.2ghz (~5kPPD). Even considering that the Fermi card will use more power, it is still a very efficient way to crunch considering the wattPD.

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My HD 6670 DDR3 does one WU in about 12 minutes (one WU at a time), a GTS 450 does about the same according to Brandonwh64 (so a higher middle class nVidia is doing as well as a lower middle class AMD of ~50 watts peak).

I have an "old" qx9770 running stock and 2 ATI 5850s. If I'm not doing anything important on my PC, I don't mind having the cpu and gfxs working 100%.

Just need to see how to set it all up. Not even sure 5850s will work...

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HD 5850s will work. You could let those run one GPU WU per GPU (and two normal WUs on the two cores that do not drive the GPUs), or alternatively you could run multiple WUs per GPU (still using 2 cores for the GPUs and 2 for regular WUs and/or other tasks).
The latter should be giving a higher daily output as well as a better output per watt, but it will probably bring the power draw of the GPUs closer to their peak power draw.
The firstmentioned option will be using slightly less power and generate less output, but will be easier to setup.

However, I think that [Ion], Norton, HammerOn or ChickenPatty can give better advice on this.

I am crunching on two machines, my main workstation has a Core 2 Duo E8500 and a GeForce GTX 560 Ti (which I will put to work when I am AFK now that I need those 25k points), the second PC is an Athlon XP 2500+.

HD 5850s will work. You could let those run one GPU WU per GPU (and two normal WUs on the two cores that do not drive the GPUs), or alternatively you could run multiple WUs per GPU (still using 2 cores for the GPUs and 2 for regular WUs and/or other tasks).
The latter should be giving a higher daily output as well as a better output per watt, but it will probably bring the power draw of the GPUs closer to their peak power draw.
The firstmentioned option will be using slightly less power and generate less output, but will be easier to setup.

However, I think that [Ion], Norton, HammerOn or ChickenPatty can give better advice on this.

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Not sure how to go about setting up what cores do what...

I have the impression my GPUs aren't working (0-25% load on the first 5850 but 0% load on the other 5850).

My cpu is working nicely though.

I did try setting some things in my device profile, but maybe I missed something?

@Lukfi: In a month, it will be do-able to crunch on the AthlonXP and Core 2 Duo and get 25000 WCG points (which should not be confused with BOINC points). There is no strict need to crunch on the GTX 560 although it is encouraged to do so if you do not mind the additional power draw.