In 2006, 2 rotavirus vaccines were licensed. The authors summarize the impact of rotavirus vaccination on hospitalizations and deaths from rotavirus and all-cause acute gastroenteritis (AGE) during the first 10 years since vaccine licensure, including recent evidence from countries with high child mortality. They found that data from 57 studies in 27 countries showed median reductions of 80% in rotavirus hospitalizations, 38% in all-cause gastroenteritis hospitalizations, and 42% reduction in diarrhea mortality among children <5 years of age since licensure of rotavirus vaccines a decade ago.