Sponges represent one of the top-ranking sources of marine fungal diversity [1]. Many sponge-associated fungi are capable of producing structurally diverse and highly bioactive secondary metabolites [2]. Moreover, metabolites derived from sponge-associated fungi facilitate the development of sustainable products for the pharmaceutical, nutraceutical, and cosmetic industries [3]. Hence, we have paid ongoing attention to bioactive metabolites from sponge-associated fungi.

The fungus Nigrospora oryzae was isolated from the marine sponge Clathrina luteoculcitella collected off Yongxing Island in the South China Sea. Nigrospora oryzae produces plenty of metabolites [4]. However, there is as yet no study on secondary metabolites isolated from the sponge-associated Nigrospora oryzae.

The strain was cultured in Czapek–Dox medium at room temperature for 40 days in artificial seawater. The culture broth was extracted three times with EtOAc, and the EtOAc solvent was removed under vacuum to yield...

Keywords

CDCl3 Secondary Metabolite EtOAc CD3OD Diketopiperazines

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgment

This work was financially supported by grants from the National Marine ‘863’ Project (2013AA092902), the National Natural Science Foundation of China (21172094, 41376155, 21372100, U1301131), and the Science and Technology Program of Guangzhou, China (2006Z-E4041).