Honestly, you should probably read all 25 responses, but a few highlights include:

You can get married, and your spouse can move in if you own a house

Your leaning toward good or evil isn't represented by a number

Boss fights are not just enemies with more HP. They use a variety of tactics

Don't count on destructible environments

Skyrim has tavern brawls!

Personally, I'm a little disappointed by the decision to keep the old "restore your magic weapon by refilling it with soul gems" mechanic, but other than that, this Q&A leaves me more excited for Skyrim than ever.