No Python developers here? :-)
I've submitted to PyCon US for the first time and now I'm checking the website every day for the results (I know that they will probably send an email first, but still :-P).

I will submit to the International conference on Relation Algebraic Methods in Computer Science with a theory of transactions in distributed information systems. This should solve the problems with transactions in NoSQL databases.

I have only done CFPs so far, my first was to an Omaha Security conference, Kernelcon and the second was to KCDC, Kansas City Developer Conference. I actually got accepted to speak at Kernelcon (my first!) and still am waiting to hear on KCDC.

Actually, today I submitted my first time ever. I'd like to speak about how important communication is and what helped me to improve it at DevDay, a small one day developer conference in Dresden, Germany.

I got lucky. Being one of the co-founders of DEV, the first few times I gave talks was because people approached me about it. The first CFP I submitted (which I didn't get!) was a joint talk with someone who had already been giving talks regularly. That helped me feel more comfortable about putting myself out there.

I think 'now' is when you have an idea or message you'd like to share. If you're noodlin' with some concepts, I'd go through the exercise of putting a talk together. If that's uphill battle, maybe you're not ready but chances are, you have something to say and you are ready!