Jun 1, 2020

Natural killer (NK) cells were discovered 40 years ago, by their ability to recognize and kill tumor cells without the requirement of prior antigen exposure. Since then, NK cells have been seen as promising agents for cell-based cancer therapies. However, NK cells represent only a minor fraction of the human lymphocyte population. Their skewed phenotype and impaired functionality during cancer progression necessitates the development of clinical protocols to activate and expand to high numbers ex vivo to be able to infuse sufficient numbers of functional NK cells to the cancer patients. Initial NK cell-based clinical trials suggested that NK cell-infusion is safe and feasible with almost no NK cell-related toxicity, including graft-versus-host disease. Complete remission and increased disease-free survival is shown in a small number of patients with hematological malignances. Furthermore, successful adoptive NK cell-based therapies from haploidentical donors have been demonstrated. Disappointingly, only limited anti-tumor effects have been demonstrated following NK cell infusion in patients with solid tumors. While NK cells have great potential in targeting tumor cells, the efficiency of NK cell functions in the tumor microenvironment is yet unclear. The failure of immune surveillance may in part be due to sustained immunological pressure on tumor cells resulting in the development of tumor escape variants that are invisible to the immune system. Alternatively, this could be due to the complex network of immune-suppressive compartments in the tumor microenvironment, including myeloid-derived suppressor cells, tumor-associated macrophages, and regulatory T cells. Although the negative effect of the tumor microenvironment on NK cells can be transiently reverted by ex vivo expansion and long-term activation, the aforementioned NK cell/tumor microenvironment interactions upon reinfusion are not fully elucidated. Within this context, genetic modification of NK cells may provide new possibilities for developing effective cancer immunotherapies by improving NK cell responses and making them less susceptible to the tumor microenvironment. Within this review, we will discuss clinical trials using NK cells with a specific reflection on novel potential strategies, such as genetic modification of NK cells and complementary therapies aimed at improving the clinical outcome of NK cell-based immune therapies.

Living cells inside the body could be placed under surveillance—their location and migration noninvasively tracked in real time over many days—using a new method developed by researchers at KAUST.

The technique uses magnetic core-shell iron nanowires as nontoxic contrast agents, which can be implanted into live cells, lighting up those cells’ location inside a living organism when scanned by magnetic resonance imaging (MRI). The technique could have applications ranging from studying and treating cancer to tracking live-cell medical treatments, such as stem cell therapies.

May 28, 2020

A look at how governments around the world are using surveillance technology during this pandemic.

States all over the world have begun to embrace surveillance technology as a weapon against the COVID-19 pandemic. More than ever, it is crucial that civil society groups monitor these decisions and defend individual rights as well as the rule of law.

May 26, 2020

According to the video, the vehicle could be especially well suited for recon or scouting missions, thanks to its quiet electric drivetrain. A surveillance drone could be launched from the truck bed as well.

May 21, 2020

Interesting articles on theranostic iron nanowires. I’m interested in watching all aspects of development of nanobots, because I think it may lead to new forms of treatments for superlongevity and superintelligence.

Phys.org: Iron nanorobots go undercover to do surveillance on living cells in real time:

May 19, 2020

In an effort to create first-of-kind microelectronic devices that connect with biological systems, University of Maryland (UMD) researchers are utilizing CRISPR technology in a novel way to electronically turn “on” and “off” several genes simultaneously. Their technique, published in Nature Communications, has the potential to further bridge the gap between the electronic and biological worlds, paving the way for new wearable and “smart” devices.

“Faced with the COVID-19 pandemic, we now have an even deeper understanding of how ‘smart’ devices could benefit the general population,” said William E. Bentley, professor in UMD’s Fischell Department of Bioengineering and Institute for Bioscience and Biotechnology Research (IBBR), and director of the Robert E. Fischell Institute for Biomedical Devices. “Imagine what the world would be like if we could wear a device and access an app on our smartphone capable of detecting whether the wearer has the active virus, generated immunity, or has not been infected. We don’t have this yet, but it is increasingly clear that a suite of technologies enabling rapid transfer of information between biology and electronics is needed to make this a reality.”

With such a device, this information could be used, for example, to dynamically and autonomously conduct effective contact tracing, Bentley said.

May 18, 2020

The contracting giant will provide the JAIC with “data labeling, data management, data conditioning, AI product development, and the transition of AI products into new and existing fielded programs,” according to the GSA news release.

“The delivered AI products will leverage the power of DoD data to enable a transformational shift across the Department that will give the U.S. a definitive information advantage to prepare for future warfare operations,” the release said.

May 14, 2020

In a major blow to citizens’ privacy, the US Senate voted today to give law enforcement agencies such as the FBI and CIA the power to look into your browser history without a warrant. Thanks, Mitch McConnell.

Senators Ron Wyden from Oregan and Senator Steve Daines of Montana led the charge to insert privacy protections into the Patriot Act, which gives law enforcement agencies power for surveillance in order to maintain national security. However, the privacy protection amendment fell short by just one vote, as many senators who may have voted in favor of it didn’t show up.

May 13, 2020

Almost three months after arriving in Guam, a pair of MQ-4C Triton autonomous, unmanned aircraft have integrated into fleet operations and training flights and stretched the Navy’s maritime domain awareness across the Indo-Pacific, according to the Navy.

The Navy is counting on the Triton, which can operate at greater than 50,000-foot altitudes and at the 2,000-mile-plus range, to provide an unmanned platform for persistent, maritime intelligence, surveillance, and reconnaissance capabilities and work alongside its manned fleet of reconnaissance and surveillance patrol aircraft. The Tritons with Unmanned Patrol Squadron 19 – the Navy’s first unmanned aircraft squadron – arrived in Guam in late January to support CTF-72, which oversees the patrol, reconnaissance and surveillance force in the U.S. 7th Fleet region.