{"title"=>"Joint effects of febrile acute infection and an interferon-γ polymorphism on breast cancer risk", "type"=>"journal", "authors"=>[{"first_name"=>"Yi", "last_name"=>"Su", "scopus_author_id"=>"55705002000"}, {"first_name"=>"Lu Ying", "last_name"=>"Tang", "scopus_author_id"=>"12042602300"}, {"first_name"=>"Li Juan", "last_name"=>"Chen", "scopus_author_id"=>"57192609332"}, {"first_name"=>"Jian Rong", "last_name"=>"He", "scopus_author_id"=>"37118683700"}, {"first_name"=>"Feng Xi", "last_name"=>"Su", "scopus_author_id"=>"7102864885"}, {"first_name"=>"Ying", "last_name"=>"Lin", "scopus_author_id"=>"56255558200"}, {"first_name"=>"Wei Qing", "last_name"=>"Chen", "scopus_author_id"=>"35263583700"}, {"first_name"=>"Xiao Ming", "last_name"=>"Xie", "scopus_author_id"=>"36027766100"}, {"first_name"=>"Ze Fang", "last_name"=>"Ren", "scopus_author_id"=>"16305021500"}], "year"=>2012, "source"=>"PLoS ONE", "identifiers"=>{"sgr"=>"84862074191", "pmid"=>"22624006", "pui"=>"364850170", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "scopus"=>"2-s2.0-84862074191", "doi"=>"10.1371/journal.pone.0037275", "issn"=>"19326203"}, "id"=>"6e619828-7a5a-37be-bd3a-44bc2e99cf2a", "abstract"=>"BACKGROUND: There is an inverse relationship between febrile infection and the risk of malignancies. Interferon gamma (IFN-γ) plays an important role in fever induction and its expression increases with incubation at fever-range temperatures. Therefore, the genetic polymorphism of IFN-γ may modify the association of febrile infection with breast cancer risk.\\n\\nMETHODOLOGY AND PRINCIPAL FINDINGS: Information on potential breast cancer risk factors, history of fever during the last 10 years, and blood specimens were collected from 839 incident breast cancer cases and 863 age-matched controls between October 2008 and June 2010 in Guangzhou, China. IFN-γ (rs2069705) was genotyped using a matrix-assisted laser desorption/ionization time-of-flight mass spectrometry platform. Odds ratios (OR) and 95% confidence intervals (CIs) were calculated using multivariate logistic regression. We found that women who had experienced ≥1 fever per year had a decreased risk of breast cancer [ORs and 95% CI: 0.77 (0.61-0.99)] compared to those with less than one fever a year. This association only occurred in women with CT/TT genotypes [0.54 (0.37-0.77)] but not in those with the CC genotype [1.09 (0.77-1.55)]. The association of IFN-γ rs2069705 with the risk of breast cancer was not significant among all participants, while the CT/TT genotypes were significantly related to an elevated risk of breast cancer [1.32 (1.03-1.70)] among the women with <1 fever per year and to a reduced risk of breast cancer [0.63 (0.40-0.99)] among women with ≥1 fever per year compared to the CC genotype. A marked interaction between fever frequencies and the IFN-γ genotypes was observed (P for multiplicative and additive interactions were 0.005 and 0.058, respectively).\\n\\nCONCLUSIONS: Our findings indicate a possible link between febrile acute infection and a decreased risk of breast cancer, and this association was modified by IFN-γ rs2069705.", "link"=>"http://www.mendeley.com/research/joint-effects-febrile-acute-infection-interferon%CE%B3-polymorphism-breast-cancer-risk-1", "reader_count"=>2, "reader_count_by_academic_status"=>{"Researcher"=>1, "Professor"=>1}, "reader_count_by_user_role"=>{"Researcher"=>1, "Professor"=>1}, "reader_count_by_subject_area"=>{"Medicine and Dentistry"=>1, "Agricultural and Biological Sciences"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>1}}, "group_count"=>0}