yonkoma (four-panel manga) you read down and left. most manga you read left and down. The formatting of the panels should help you out figuring out which way to read manga. formatting of manga panels are pretty rigid industry-wide, so for conventional manga you'll have skinnier margins running vertically and wider margins running horizontally. yonkoma formatting is flipped so the skinnier margins run horizontally and the wider margins run vertically. The panel layout should lead your eyes the right direction.