Indications

Use Four and a tail drops for regulation of estrus in female dogs and cats to detain and interrupt estrus, as well as in male ones to decrease sexual activity and correct behaviour.

Contraindications

The drug is contraindicated for female dogs and cats since 3 days after estrus beginning; immature, pregnant and lactating animals, as well as for animals of both sexes with genital diseases, breast tumors, diabetes, hormonal disorders and increased individual sensitivity to the drug components.

Dosage and administration

Four and a tail drops for regulation of estrus and tablets are intended for individual oral administration 1-2 hours before feeding (forced administration on the base of tongue or use with a treat according to the following schedule).
Use Four and a tail drops for regulation of estrus and tablets in female cats to regulate estrus in accordance with the following schedule (Table 1):

Table 1

Drug administration purpose

Term

Dosage form

Dose

Duration

to interrupt

estrus

up to 3 days after

estrus beginning

Drops

every day,

6 drops (0.3 ml)

within 8 days

Tablets

every day,

1 tablet

within 8 days

to

detain estrus

to begin in

anestrus period

Drops

6 drops (0.3 ml) once in 2 weeks

up to 18 months

Tablets

1 tablet once in

2 weeks

up to 18 months

A break (2 months at least) is recommended before beginning of new course of use. In case of normal physiological sexual cycle in treated female cat, you may repeat the course. If estrus beginning is difficult to be determined, you would rather detain it than interrupt.

Depending on body weight, use Four and a tail drops for regulation of estrus and tablets in female dogs in accordance with the following scheme:

In order to detain estrus, start drug administration 7-15 days before its beginning. In the light of body weight, doses are listed in Table 2. Administration duration depends on desired date of estrus detainment (up to 32 days). Estrus may start in a few days after the drug withdrawal. In case of long-term drug administration (about a month), estrus usually starts in 4-6 or sometimes in 2-9 months.

Four and a tail drops for regulation of estrus dosage to detain estrus in female dogs depending on body weight.

Body weight, kg

Megestrol acetate daily dose, mg

Daily dose:

Drug daily dose (tablets or drops)

drops

ml

<5

2.5

3

0.15

0.5

6-10

5

6

0.25

1

11-15

7.5

8

0.4

1.5

16-20

10

10

0.5

2

21-30

15

15

0.75

3

31-40

20

20

1

4

41-50

25

25

1.25

5

51-60

30

30

1.5

6

In order to interrupt estrus, use the drug in appearance of the first signs (within 3 days after beginning). In the light of body weight, dosage is listed in Table 3. Administer daily dose during the first 3 days of course, then half it within the following 7 days. After the drug withdrawal estrus usually starts in 4-6 months or sometimes in 2-9 months.

Four and a tail drops for regulation of estrus dosage to interrupt estrus in female dogs depending on body weight.

Body weight,

kg

Daily dose:

Drug daily dose:

Drug daily dose (tablets or drops)

megestrol acetate, mg

drops

ml

<5

10

10

0.5

2

6-10

20

20

1

4

11-15

30

30

1.5

6

16-20

40

40

2

8

21-30

60

60

3

12

31-40

80

80

4

16

41-50

100

100

5

20

51-60

120

120

6

24

Female dogs are recommended to be administered not more than twice a year.

In order to decrease sexual activity and correct behaviour, males are administered in the following doses:

male cats - 6 drops (0.3 ml) or 1 tablet per animal every day within 5-7 days, then once a week till behaviour correction;

male dogs - 10 drops (0.5 ml) per 5 kg of body weight or 1 tablet per 2.5 kg every day within the first 7 days, then a half of daily dose within following 14 days.

Adverse events

Adverse events and complications are generally not observed in case of Four and a tail drops for estrus regulation and tablets administration as per package insert. Body weight increase, mild depression or aggression may be rarely observed.