PeptiCRAD

PeptiCrad is conceived to overcome the biggest limitation of the oncolytic vaccine platform e.i. the virus immune-dominance.

In fact, our group and other had demonstrated that the treatment of oncolytic viruses has a dual mode-of-action, the oncolysys (direct lysis of the infected tumor cell) and a "vaccine" effect that occurs triggering some degrees of anti-tumor immune response (Figure below).

Naked Oncolytic vaccine

Nevertheless the most significant limitation with the naked viruses is that the majority of the immune response is towards the virus and only a small degree of the response is directed towards the tumor.

To overcome this limitation we have developed PeptiCrad, a "virus in tumor's clothing"!