In this app, we investigate the effect of the Parkinson's Disease in the
early olfactory system.

The antennal lobe is the first neuropil in the olfaction sensory pathway,
which can be decomposed to ~50 subregions, called glomerulus. Each glomerulus
consists of some 50 olfactory sensory neurons (input), and 3-5 projection
neurons (output). Glomeruli are interconnected by over 100 local neurons. In
total, the antennal lobe has about 2500 olfactory sensory neurons, 150 projection
neurons, and 100 local neurons.

We first reconstructed the healthy model of the antennal lobe, emulated its
response to input odorant, and visualized the ensemble response of projection
neurons of each glomerulus in both biological view and interactive plot.
Secondly, we hypothesized that the Parkinson's Disease causes the abnormal
inhibitory neurotransmitter (GABA) release in the antennal lobe, and implemented
a diseased model accordingly. The diseased model is emulated with the same input
odorant as the healthy model, and its response is provide below alongside the
result of the healthy model.