A Novel Forensic Approach to DNA Database Construction and Population Genetic Analysis

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With the increased use of genetic markers such as short tandem repeats (STRs) for human identification, concerns of possible population stratification have arisen. Autosomal STRs are the most commonly used form of DNA-based human identification as they offer several advantages for forensic applications: high levels of polymorphism, relatively small sizes, and the requirement for small amounts of DNA. The forensic use of Y chromosomal markers for human identification purposes has also increased rapidly. The issue of population substructure has been addressed and we conclude that there may be substructure associated with autosomal STRs, but the statistical difference is negligible when dealing with forensically relevant samples. Consideration of population stratification and the appropriateness of databases are particularly important for Y STR data as they occur as lineage-specific haplotypes, which can theoretically be differentially partitioned in populations. We have addressed possible substructure and demonstrated the need for larger databases.Applied Biosystems (2001) AmpFlSTRAr IdentifierAr, ProfilerAr CofilerAr PCR
Amplification Kit Usera#39;s Manual, Foster City, CA, P/N 4323291, 4330284,
4305346. 167. Promega Corporation (rev. 2007) PowerplexAr Y Amplification Kit
Usera#39;sanbsp;...

Title

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A Novel Forensic Approach to DNA Database Construction and Population Genetic Analysis

Author

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Craig O. O'Connor

Publisher

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ProQuest - 2008

ISBN-13

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