Warm conditions in the Arctic Ocean have been linked to cold mid-latitude winters. Observations and simulations suggest that warm Arctic anomalies lead to a dip in CO2 uptake capacity in North American ecosystems and to low crop productivity.

EMBO Journal

Tetanus neurotoxin (TeNT) secreted by Clostridium tetani is the causative agent of the spastic paralysis distinctive of human tetanus. TeNT is structurally related to the family of botulinum neurotoxins (BoNTs) produced by Clostridium botulinum that cause flaccid paralysis by disabling synaptic exocytosis at peripheral cholinergic neurons. By contrast, TeNT […]

Two sister chromatids must be held together by a cohesion process from their synthesis during S phase to segregation in anaphase. Despite its pivotal role in accurate chromosome segregation, how cohesion is established remains elusive. Here, we demonstrate that yeast Rtt101-Mms1, Cul4 family E3 ubiquitin ligases are stronger dosage suppressors of loss-of-fun […]

Effectiveness of EGFR treatment is impaired through an early adaptive response. TNF–JNK–Axl–ERK signaling contributes to this primary resistance to EGFR inhibition and might serve as novel target to improve EGFR inhibition.

Loss of inhibition in a circuit in the primary somatosensory cortex that controls the activity of layer 5 neurons drives pain hypersensitivity. Restoring this inhibition resets the inhibitory–excitatory balance, producing analgesia.

A combination of computational modeling, neuroimaging and a causal manipulation of brain activity in humans reveals how the brain represents beliefs about how our choices will affect those of others we interact with.

A Cre-dependent capsid selection method, CREATE, was used to produce adeno-associated viral vectors that allow gene delivery to the entire central and peripheral nervous systems, with multicolor labeling of single cells.

Here at Wildscreen we’re Crowdfunding to bring the ocean to our hometown (Bristol, UK) to raise awareness about our ocean and the amazing creatures that call it home. We need your help! Help us! We need our supporters to help us submerge Bristol into a wild and watery wonderland this October. From sculptures to street […]

As it’s Arkive’s 14th birthday, we thought we would celebrate by sharing 14 ways that you can help save the world! By just doing one of these things you can make a difference, more than one you can make a big difference, and by doing all 14 you are very much on track to save […]

Daniel Craven is Durrell Wildlife Conservation Trust‘s Volunteer Manager, based at Jersey Zoo since 2001. A former professional footballer, Daniel is a lover of travel, animals and conservation. Durrell’s Underdogs is his first film and was made with the fantastic team of Dean Maryon, Bex Bohea, Shaz Syed and Marc Mitchell. It is an official […]

Arkive would like to introduce The Wait, a short film from production company Contra, which follows the journey of a wildlife photographer on a hunt to document the elusive European bison in its natural habitat of the Romanian mountains. The story details how it can take weeks to capture a shot, and the patience required to […]