Adriamycin

Adriamycin

(ā′drē-ə-mī′sən)

A trademark for the drug doxorubicin.

Adriamycin

An anthracycline antibiotic with antineoplastic activity, which is used to treat haematologic malignancies, especially leukaemias, but also carcinomas and solid tumours (for which it is not particularly effective); its efficacy is hampered by cardiotoxicity that increases as the cumulative dose passes 500 mg/mm3.Adverse effects Nausea, vomiting, neutropenia; about one-fourth of Adriamycin-treated patients develop late cardiac abnormalities once the cumulative dose passes 450 mg/mm2 including cardiac failure, dysrhythmia and sudden death; post-mortem examination of the heart reveals myocardial fibrosis.

adriamycin

Doxorubicin HCl Oncology An anthracycline antibiotic with antineoplastic activity, used to treat both leukemia and solid tumors; its efficacy is hampered by cardiotoxicity that ↑ as the cumulative dose passes 500 mg/mm3

Adriamycin

Doxorubicin. An anticancer drug which acts by interfering with cell division.

Even in the world of toxic chemotherapy, Adriamycin and its fellow anthracyclines are notoriously dangerous: Slamon and Press refer to the "well-known, long-term, and life-threatening problems associated with anthracyclines.

Of 1,477 women who participated in the randomized, controlled trial (all of whom were postmenopausal, had axillary lymph node involvement, and had tumors with either estrogen or progesterone receptors), 566 were treated with 6 months of chemotherapy (cyclophosphamide, Adriamycin, and 5-fluorouracil) followed by 5 years of tamoxifen, she said.

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