Focusing on the search limits “clinical trial” and “human,” Winchester and Bavry (1) discuss the limitations of the search limit function in MEDLINE with respect to constructing meta-analyses. We agree with the authors that a thorough literature search is of the utmost importance in constructing meta-analyses. This process requires a detailed description of the search strategy and a thorough understanding of the limitations of Medical Subject Headings (MeSH) and the search limit function of PubMed.

The exact way in which the authors searched MEDLINE via the PubMed interface is unclear because they provided few details about their search strategy. The authors indicated searching for the term epitifibatide. We assume that they used the correct term eptifibatide; otherwise, fewer articles would have been identified.