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World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar. Best Paper Award : Dr. Muhammad Baqir MR Fakhrildin
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Abstract

The present study was carried out to investigate the protective effects
of Glycyrrhiza glabra L roots powder juice on some biochemical
parameters in normal (non- CCl4-induced hepatic injury) and CCl4-
induced hepatic injury rabbits. A dose of 2.0 g/kg body weight of
aqueous extract of roots was orally administered daily to normal and
CCl4-induced hepatic injury rabbits for 7 days. The levels of AST,
ALT, ALP, creatinine and urea were significantly (P<0.05) increased
in the serum of CCl4-induced hepatic injury rabbits as compared to the
(non-CCl4-induced hepatic injury rabbits. In contrast, glucose
concentration was significantly decreased in CCl4-induced hepatic
injury rabbits, as compared to the non- CCl4-induced hepatic injury rabbits. Significant
reduction in the hepatic enzymes levels AST, ALT, ALP, serum creatinine, serum urea and
improvement of serum glucose was found in animals treated with the extract before CCl4-
induced hepatic injury. The present study demonstrated that the G. glabra roots extract had a
significant effect in liver functions in acute liver diseases when it was given in a single daily
dose of 2.0 gm/kg rabbit body weight for seven days. Therefore the aqueous extract of G.
glabra roots can be used for prevention and treatment of liver disorders.