Pathway Focus: The Interferon Pathway

Gibco® Recombinant Interferons

High biological activity

High purity

Proven compatibility with Gibco® media

Gibco® recombinant interferons are used in a wide variety of investigations requiring pathway stimulation. Gibco® recombinant interferons have been bioassayed in cells cultured using Gibco® media. So if you’re already using Gibco® media, you can have more confidence in the compatibility of these reagents in your cell culture–based assays.

Interferons are released in response to pathogens to trigger the immune system response. Upon binding to surface receptors, interferons activate the JAK/STAT pathway.

Many scientists use Gibco® recombinant interferons to stimulate cells during investigations of downstream signaling events. Gibco® recombinant interferons may also be used as standards in your assays.

We offer a range of human recombinant interferons—IFN-α, β, and γ. We also offer IFN-γ from human, mouse, rat, and swine.

Gibco® cytokines and growth factors are high-purity recombinant proteins with high bioactivity. To help ensure Gibco® recombinant proteins are of the highest quality, each protein is analyzed for purity and structural homogeneity.

ABfinity™ recombinant rabbit monoclonal antibodies are produced from specific recombinant clones, so antibody performance is consistent over time. ABfinity™ antibodies are available for many targets, including JAK1 [phospho-Y1022], STAT1 [phospho-Y701], STAT4, and STAT6 [phospho-Y641].

JAK/STAT signaling is important in regulating immune responses and autoimmune diseases, especially when interferon-γ signaling is compromised in various viral infections. ABfinity™ recombinant monoclonal antibodies are ideal reagents for signaling pathway research. ABfinity™ technology helps ensure consistent antibody performance, so you don’t have to reoptimize your assay with each new lot.

Rapidly and Reliably Measure Secreted Interferon

Interferons are perhaps best known for their immunomodulatory properties—activating immune system cells such as macrophages and natural killer cells.

In addition, interferons are secreted in the bloodstream in response to invaders such as viruses and bacteria, and are thought to play a role in regulating cellular growth and fighting certain tumors. Different types of interferons such as IFN-β, -α, and - utilize different cell-surface receptors.