Immunogenicity of cell extract proteins in pulmonary nocardiosis

Summary

Crude protein fraction (CPF) ofNocardia asteroides was fractionated into F1 and F2 subfractions. CPF F1 elicited both cellular as well as humoral immune responses, while F2 was found to be non-immunogenic. Mice immunized with CPF F1 and challenged with calculated LD50 dose ofN. asteroides exhibited significant protection against nocardiosis as compared to non-immunized mice. CPF was found to be the best immunogen.