Individualized medicine

Studies in the Ischemic Heart Disease Program also focus on individualized medicine, with a major priority being the Tailored Antiplatelet Initiation to Lessen Outcomes Due to Decreased Clopidogrel Response After Percutaneous Coronary Intervention (TAILOR-PCI) trial, which is funded by the Mayo Clinic Center for Individualized Medicine.

This prospective, international, multicenter, randomized trial is testing the hypothesis that using a genotype-guided dual anti-platelet therapy strategy in patients undergoing percutaneous coronary intervention will result in significantly improved cardiovascular outcomes in patients with reduced-function CYP2C19 alleles.

Coronary physiology and imaging

The Cardiovascular Research Center is focused on evaluating coronary endothelial function and microvascular disease in people with symptoms of myocardial ischemia with normal coronary arteries or mild atherosclerosis.

Researchers are evaluating new risk factors and candidate genes that confer risk of endothelial dysfunction and conducting a National Institutes of Health-funded clinical trial exploring novel mechanisms and therapies for endothelial dysfunction.

Spontaneous coronary dissection

Researchers in the Ischemic Heart Disease Program are looking at the mechanisms and genetics of spontaneous coronary dissection, one of the major causes of myocardial infarction in young women.

Percutaneous and surgical revascularization

Stress cardiomyopathy

Mayo Clinic physicians and researchers in the Cardiovascular Research Center have strong expertise in the area of stress cardiomyopathy. An important differential diagnosis of acute coronary syndrome is the relatively recently described condition called apical ballooning syndrome, also known as takotsubo cardiomyopathy, stress cardiomyopathy and broken heart syndrome.

Mayo Clinic has a prospective registry for apical ballooning syndrome, and researchers are participating in an international registry to better understand the clinical features and outcomes of patients with this unique condition, which occurs mainly in postmenopausal women.

Reprint Permissions

A single copy of these materials may be reprinted for noncommercial personal use only. "Mayo," "Mayo Clinic," "MayoClinic.org," "Mayo Clinic Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation for Medical Education and Research.