Mitochondrial ADP/ATP carriers, such as SLC25A31, are nuclear-coded mitochondrial proteins that catalyze the exchange of ATP generated in mitochondria by ATP synthase (see MIM 108729) against ADP produced in cytosol by most energy-consuming reactions (Dolce et al., 2005 [PubMed 15670820]).[supplied by OMIM, Mar 2008].. Additionally we are shipping SLC25A31 Antibodies (43) and many more products for this protein.

Male mice with disruptions of Slc25a31 are sterile and display an early meiotic arrest phenotype.

Compares and contrasts all the known human SLC25A (show SLC25A25 Proteins)* genes and includes functional information.

Data show the specific role of the ANT4 isoform in spermatozoid bioenergetics.

data define common and distinct biochemical characteristics of ANT4 in comparison to ANT1 (show SLC25A4 Proteins), 2 and 3 providing a basis for study of its unique adaptation to germ cells

data highlight a cytoprotective activity of ANT4, and provide a novel dichotomy in the ANT isoform sub-family with ANT1 and 3 isoforms functioning as pro-apoptotic while ANT2 and 4 isoforms render cells resistant to death inducing stimuli

The co-localization of SFEC and glycolytic enzymes in the fibrous sheath supports a growing literature that the principal piece of the flagellum is capable of generating and regulating ATP independently from mitochondrial oxidation in the mid-piece.

SLC25A31 Protein Profile

Protein Summary

Mitochondrial ADP/ATP carriers, such as SLC25A31, are nuclear-coded mitochondrial proteins that catalyze the exchange of ATP generated in mitochondria by ATP synthase (see MIM 108729) against ADP produced in cytosol by most energy-consuming reactions (Dolce et al., 2005