The petechiae may give way to ecchymoses (like a petechial rash, but covering larger areas) and other haemorrhagic phenomena such as melaena (bleeding from the upper bowel, passed as altered blood in the faeces), haematuria (blood in the urine), epistaxis

Dr Reddy's also noted that adverse events of special interest (bone fracture, haematuria, heart failure, cardiac ischemia, oedema and weight gain) were numerically under-represented in the 10mg group compared to Actos.