An insiders guide to the best new places to eat, shop, stay and visit—from the Pacific Rim to the Adriatic Coast, Lake Michigan to the Seine.

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Denver Art Museum | Denver
Reflecting the nearby Rocky Mountain peaks in its titanium-clad angles, the Frederic C. Hamilton Building at the Denver Art Museum—the first completed public work in this country by architect Daniel Libeskind (in collaboration with Denver-based Davis Partnership Architects)—nearly doubles the museum's size. The new building adds almost 40,000 square feet of new exhibition space. A sharply cantilevered section of the structure juts across the street toward the existing Gio Ponti–designed North Building, to which it is connected by an enclosed glass-and-steel bridge (100 W. 14th Avenue Pkwy.; 720/865-5000, denverartmuseum.org).

Emporium | Paris
Textile enthusiast Françoise Dorget, famous for her elegantly curated Caravane shops, has opened Emporium, in the bustling Bastille. Behind the lacquered-red facade, the blue-tinted whitewashed walls are lined with finds not just from Europe, Japan, India, Morocco, Mexico and Brazil but dozens of other locations around the world—a brilliant blend of traditional crafts and modern design. Vegetable-dyed textiles from Calcutta are illuminated by Korean designer Zinoo Park's industrial lights. British design group Gusto's straw-filled Baley benches contrast with Stephanie Bergman's ceramics (22 rue Saint Nicolas; 33+1/53.17.18.55).

Hotel deLuxe | Portland, OR
The Aspen Hotel Group's 130-room Hotel deLuxe, near the trendy Pearl District, is lavishly decorated in a style inspired by Hollywood's golden-era glamour. San Francisco designer David Hill used a rich mix of materials in the public areas, along with moderne furniture that recalls the '20s through '40s. In the lobby, a 12-foot-high mirror-framed rear-projection screen displays classic movie stills that change hourly. The guest rooms feature sunny California color schemes and beds with upholstered headboards in a distinctive '40s profile. Rooms from $159 (729 SW 15th Ave.; 866/895-2094, hoteldeluxeportland.com).

Skin + Bones: Parallel Practices in Fashion and Architecture | Los Angeles
The intersection of what we wear and where we live comes under close scrutiny in the Museum of Contemporary Art's Skin + Bones: Parallel Practices in Fashion and Architecture exhibition on view from November 19 through March 5, 2007. Presenting the work of approximately 40 fashion designers and architects—including Jean Nouvel, Frank Gehry, Toyo Ito, Azzedine Alaïa and Yohji Yamamoto (Selfridges department store by Future Systems is above)—in thematic groupings, curator Brooke Hodge, who also penned much of the corresponding catalog, illustrates the blended boundaries of the two high-style disciplines (250 S. Grand Ave.; 213/626-6222, moca.org).

Miss Sixty | Riccione, Italy
Pop-fashion fav Miss Sixty has branched out from denim into lodging with its four-star Sixty Hotel. Located downtown in the heart of this popular Adriatic coastal town, every one of its 40 rooms was decorated by a different artist under the guidance of Wicky Hassan, the Sixty Group's creative director and president. (And every room has a webcam so that guests can communicate with each other.) The splashy structure with egg-shaped openings cut into the outer facade shares its address with a restaurant, bar and boutique to up the fashion quotient. Rooms from approximately $200 (via Milano, 54; 39+0541/303669, sixtyhotel.com).

Showroom | Boston
Recently opened Showroom has become the hot furniture shop in town. Its cast of suppliers, which includes Cappellini, Promemoria, Driade, Flexform and Gervasoni, reads like an Italian-design honor roll. Owner Doug Gates, who created the 3,000-square-foot airy space in the city's chic Park Plaza District, also offers to solve your storage problems with Poliform closets and to help outfit your kitchen with Varenna's sleek cabinetry (240 Stuart St.; 617/482-4805, showroomboston.com).

Eleven City Diner | Chicago
Eleven City Diner, a new South Loop eatery, sports a sleek, retro-chic decor (designed by owner Brad Rubin with the help of Arthur Minor) and offers an unexpected take on comfort food. Here you'll find a menu that blends heart-smart fare with age-old deli classics: portobello mushroom or tuna burgers and organic oatmeal for healthy eaters, and fresh-sliced corned beef and pastrami, chopped liver, crispy latkes and matzo balls for the self-indulgent. Entrées from $9 (1112 S. Wabash Ave.; 312/212-1112, elevencitydiner.com).