FULLERTON, Calif., Oct. 17 /PRNewswire-FirstCall/ -- Agencourt
Bioscience Corporation, a Beckman Coulter company, announced today that its
Genomic Services played an important role in a newly released study from
Johns Hopkins Kimmel Cancer Center. The study follows a major report last
year that announced the discovery of 200 genes linked to breast and colon
cancers. This second report completes the study of the vast majority of
protein-coding genes and catalogs the genetic changes that occur during
tumorigenesis. Three Agencourt individuals -- James Hartigan, Douglas R.
Smith and Erick Suh -- were among the authors of the study, "The Genomic
Landscape of Human Breast and Colorectal Cancers," published in Science
Express last week.

All of the sequencing work and data generation for the study were done
by Agencourt's Genomic Services, which has a long-standing relationship
with the Johns Hopkins Kimmel Cancer Center scientists.

According to a news release issued by the Johns Hopkins Kimmel Cancer
Center, scientists involved in the study found that most cancer-causing
gene mutations are quite diverse and can vary from person to person. Of the
70 to 80 genes that are mutated in an individual cancer, about 15 are
likely to contribute to the cancer's key characteristics, and most of these
genes are different for each patient. With no more higher-frequency
mutations (such as p53) on the horizon, researchers can focus on these
less-commonly mutated genes and the complicated protein pathways that link
them. Personalized cancer genomic research paves the way for tailored
therapies and diagnostics focusing on the alterations identified in a
particular patient's cancer.

"The research findings have important implications in the develo'/>"/>

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