Lenti-HBV CAR (scFv-εRIγ, S 26)-VP(VP-CAR-LC450)

The ready-to-use lentiviral particles of Lenti-HBV CAR (scFv-εRIγ, S 26)-VP is packaged using 3rd generation of lentiviral packaging system, in which the gene of CAR will be driven by a CMV promotor. The target gene of scFv (S 26)-FcεRIγ packaged in lentiviral particles could be used for high efficency tranduction of T cells and stably integrated expression.

Specifications

Type of Therapeutics

Chimeric Antigen Receptor

Target

HBV

Expression Cassette

scFv (S26)-FcεRIγ

Clone

S 26

Promotor

CMV

Packaging System

Lentivirus

Packaging Cell

293T

Targeting Diseases

Cirrhosis; hepatocellular carcinoma (HCC); liver cancer

Target

Introduction

The large envelope protein exists in two topological conformations, one which is termed 'external' or Le-HBsAg and the other 'internal' or Li-HBsAg. In its external conformation the protein attaches the virus to cell receptors and thereby initiating infection. This interaction determines the species specificity and liver tropism. This attachment induces virion internalization predominantly through caveolin-mediated endocytosis. The large envelope protein also assumes fusion between virion membrane and endosomal membrane (Probable). In its internal conformation the protein plays a role in virion morphogenesis and mediates the contact with the nucleocapsid like a matrix protein.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.