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First, my concern was whether or not I should continue to own it as it thrashes through the process of enduring a key patent expiration on Humira, the blockbuster drug which accounts for 60% of its sales. I researched the company and published an article expressing my ambivalence towards it. Rather than writing and forgetting, I wrote and continued researching.

As I did so and evaluated AbbVie’s prospects under diverse scenarios, I concluded that it was definitely best to hold tight. There is no opportunity in the market today which offers a better safer repository for the proceeds if I were to sell.

AbbVie’s Humira sales dominance is not just a source of risk to the company. It also gives AbbVie the financial firepower to manage its way to “deconcentrate from Humira.” This is the marvelous phrase that Bill Chase, AbbVie’s CFO and Executive Vice President, used at his May 23, 2016, presentation at the UBS Global Healthcare Brokers Conference to describe AbbVie’s efforts to round out its portfolio. AbbVie is definitely not a stock where management fails to “get it.” Three SA news pieces last week are highly illustrative of AbbVie’s good work towards this end.

An important part of AbbVie’s deconcentration efforts are its ongoing programs of reaching out and partnering with other pharmaceutical companies to expand its pipeline. As recently as March 7, 2016, AbbVie announced its collaboration with Boehringer Ingelheim to advance immunology compounds, particularly as directed to Crohn’s disease and plaque psoriasis among others.

Now a phase 2 trial of the compound risankizumab is reporting favorable interim results on its path to completing the 52 week study expected to wind up in December of this year.

Boehringer Ingelheim’s website describes the deal as follows:

“. a global collaboration with AbbVie for BI 655066 and BI 655064, Boehringer Ingelheim’s two most advanced development compounds in immunology. The agreement will ensure that the two compounds can be brought forward to benefit more patients from the moment of launch, optimising the availability worldwide.AbbVie, a company with extensive experience in the immunology field, will ensure BI 655066 and BI 655064 reach their full potential to help patients across the globe, while Boehringer Ingelheim expands its capabilities in this new therapeutic area.

Both companies will share the responsibility for Phase III development of BI 655066 in the initial period and Boehringer Ingelheim will retain rights to co promote BI 655066 in asthma. Boehringer Ingelheim will also have the responsibility for further development of BI 655064, with AbbVie may elect to advance the programme after achievement of undisclosed certain clinical milestones.”

The outline of the deal required an initial payment by AbbVie of $595 million. Additional milestone payments and license fees are also envisioned but terms thereof have not been disclosed.

2. SA News from May 27, 2016: “European Ad Comm backs new use of AbbVie’s Humira for type of eye inflammation”

Ironically, continued development of Humira is a key component of the process of deconcentrating AbbVie. Humira is the goose that keeps laying golden eggs. AbbVie needs to continue its ongoing process of building up revenues from this marvelous creation. Such revenues give it the war chest that enable it to make milestone payments to companies like Boehringer Ingelheim. They also enable AbbVie to borrow billions on favorable terms when the occasion warrants.

In addition, the more revenue streams that flow from Humira, the less each single competitor will threaten AbbVie, until it too is able to prove its efficacy to combat that particular condition. AbbVie’s management has grown an impressive patent estate of no fewer than 70 patents, protecting various aspects of the drug from competition.

As pointed out in the news item, daclizumab (Zinbryta) is a long acting MS drug. AbbVie acquired co promotion rights in the United States and the EU in 2010 when it acquired Facet Biotech. Apparently, AbbVie became involved as something of a white knight, offering a premium over a lower hostile bid that Biogen had made for Facet. Now, some 6 years later, the deal will start to pay off.

One thing that is clear from reading these news items is that AbbVie will not replace any Humira revenues that may occur quickly or easily. It is a tribute to AbbVie’s management that it has painstakingly developed the pipeline that it has, piece by piece and step by step, all the while protecting and expanding Humira, the Mother Goose who has laid the golden eggs.

Disclosure: I am/we are long ABBV.

I wrote this article myself, and it expresses my own opinions. I am not receiving compensation for it (other than from Seeking Alpha). I have no business relationship with any company whose stock is mentioned in this article.

On three separate occasions in the past 30 years the country’s largest guerrilla group and a succession of governments have sat down to peace talks, and failed.

Some experts argue that since Santos pulled back from the hard line of his predecessor, the political and military landscape now favors a peace deal. “In conflict resolution negotiations happen . when a stalemate is viewed as mutual,” says Aldo Civico, an expert on the conflict at Rutgers University in New Jersey who has facilitated cease fire talks with another Colombian guerrilla group, the National Liberation Army, in the past. “Both sides are aware they won’t defeat their enemy militarily,” he says.

While Colombia is considered a rising economic power, its internal conflict holds it back, says Mr. Civico. Rebels have targeted key industries, with attacks on oil pipelines more than quadrupling in the first seven months of 2012, according to the Defense Ministry. Nearly 4 percent of gross domestic product went to military expenditures between 2007 and 2011; US defense aid is falling. Colombia needs to redirect its resources to closing the poverty gap, fighting urban violence, and luring foreign investment, says Civico.

Santos’s approval rating has plunged over the past year from 71 percent to 47 percent, in part because of security issues, according to Colombia’s Semana magazine. He aims to improve his standing as he enters the second half of his term, perhaps even trying to create a legacy as the “president of peace,” Civico says.

In the aftermath of a disaster such as superstorm Sandy, two way communication is essential. People need to be able to receive news and updates, and to request assistance and provide status updates to loved ones.

Yet after hurricane Sandy, large portions of New York, New Jersey, and other areas lost their communication systems their mobile phone network, cable TV, and Internet. Some sought out the last few pay phones as the only equipment that worked.

Above all, America’s telecommunications system depends on the electric grid. It is possible to protect the grid by burying power lines and creating alternate lines of supply. The cost of this should be balanced with the benefits of improved reliability and safety.

Alternatively, we could place permanent backup generators at each cell site, effectively isolating them from the power grid. But that just changes the nature of the challenge to one of distributing fuel to the site’s generators. As we saw in the aftermath of Sandy, even procuring fuel can be difficult after a disaster.

The aim should not be to fully counter each situation, but to focus instead on making the communications system more resilient. We need to take steps that would make the communications system capable of operating at a predetermined level of usefulness even in the face of some loss of capacity.

According to recent guests, The Lodge at Sea Island is Southern luxury at its finest. While staying here, travelers will have access to championship golf courses and multiple restaurants, not to mention a food truck. After a day spent golfing or on the beach, guests can kick back in rooms that are outfitted with oriental rugs, spacious bathrooms with deep soaking tubs and 24 hour butler service. If you’re having trouble deciding between The Lodge and its sister property, The Cloister at Sea Island, keep in mind that the latter often sees more families. On the other hand, previous guests say that the smaller Lodge’s quieter ambiance might better suit couples. Another perk for romance seekers is the on site restaurant, Colt Alison, which serves up prime cuts of beef and fresh seafood in an intimate atmosphere. In other words, you’ll want to request one of the rooms facing the Blackbank River. Previous guests gush over the number of activities available for young kids, like Camp Cloister (offering activities Mondays through Saturdays) and cookie making. Slightly older kids might enjoy crabbing or fishing off the Cloister dock or horseback riding along the south end of Sea Island beach. Recent lodgers also rave about the expansive 65,000 square foot spa, which offers treatments like the combination body polish and massage service. Regis one of their favorite hotels in Atlanta. But its location doesn’t hurt, either: You’ll find this luxurious property nestled near some of Buckhead’s most popular shopping centers. During your stay at The St. Regis, Atlanta, you can tone up at the 24 hour fitness facility and cool off at the 40,000 square foot Pool Piazza. If you need an extra dose of R consider getting a massage at the in house Remde Spa. Previous guests also recommend grabbing a bite to eat at Astor Court, which specializes in English cuisine. When it’s time to bed down, rooms feature floor to ceiling windows, handcrafted chandeliers, St. Regis robes and marble bathrooms, as well as high tech fittings like flat screen TVs and iPod docking stations. And because of its family ties, The St. Here, complimentary access to the indoor pool and fitness center are just the beginning: This hotel also wins guests over with a full service spa and family friendly luxuries like kid sized bathrobes, babysitting services and even bedtime cookies. Recent lodgers also praise the spacious rooms, which come equipped with marble bathrooms, L’Occitane toiletries and, in some rooms, private terraces. While you’re here, make sure to grab a bite to eat at Park 75; the hotel’s restaurant wins over even the most discerning foodies with its seasonal American cuisine. And according to previous visitors, the Four Season Hotel Atlanta’s customer service is fantastic: Travelers describe the staff here as incredibly professional, friendly and helpful. The hotel is home to the tranquil Ritz Carlton Spa, which offers everything from caviar and pearl facials to espresso wraps. While here, you’ll also have access to The Caf, where you can enjoy some good ol’ Southern cooking prepared in gourmet fashion. Recent guests agreed that their stays at this Ritz truly exceeded expectations. Accommodations here are bright and beautiful with cream hues, mahogany floors and marble bathrooms. Rooms also house standard creature comforts like deep soaking tubs, flat screen TVs and high speed Internet access. Five miles from the High Museum of Art and the Atlanta Botanical Garden, the Mandarin Oriental, Atlanta creates a restful and elegant atmosphere amid the city’s fast paced setting. The hotel’s original opulence is kept intact with a grand foyer, an English garden and luxurious rooms. Accommodations here are dressed in cream, beige and gray decor, goose down duvets and luxury Rivolta linens, as well as flat screen TVs, iPod docking stations and high speed Internet access. While you’re here, recent guests recommend indulging in a spa suite experience, especially the Couples Retreat a nearly four hour treatment that begins with a relaxing bath and ends with champagne and canaps. And after a long day, The Caf Bar can help you refuel with a menu of inventive contemporary American cuisine. The property is convenient to a whopping 99 holes of golf, carefully designed by renowned architects Rees Jones, Jack Nicklaus, Bob Cupp and Tom Fazio. While you play, you’ll be treated to some spectacular views of the nearby Lake Oconee.Canada Goose JacketsCanada Goose OutletCanada Goose saleCanada Goose onlinecanada goose birdcanada goose vestCanada Goose Parkacanada gooseicanadagoosereviewhttp://www.icanadagoosereview.top/
But enough about golf: The Ritz Carlton Reynolds, Lake Oconee can also brag about more than 250 gorgeous guest rooms with cushy featherbeds, marble trim bathrooms and stately cherrywood and mahogany furniture. During your stay here, you’ll have your choice of five restaurants including the extra delicious fare served at the Linger Longer Steakhouse. And of course there’s a spa, where recent visitors heap praise on the massages and facials. But though they have plenty of good things to say about the facilities at The Ritz Carlton, travelers insist that it was the hotel’s fantastic customer service that made their stays truly memorable. Children are welcomed by a variety of games, toys and kid friendly amenities, while workaholics can finish up their assignments in the business center before taking a load off at the on site spa. And for the night owls, this Loews is surrounded by some of Midtown’s favorite after hours haunts, like the Opera Nightclub and Blake’s. Recent guests also rave about this hotel’s trendy decor and up to date technology (flat screen TVs adorn every room). Many describe the guest rooms as extremely comfortable. And should you have a craving for a good meal, make sure to sit down at the hotel’s new in house restaurant, Saltwood, which boasts a menu of tasty small plates. And this iteration which sits at the heart of the ritzy, Beverly Hills esque Buckhead area certainly delivers. In fact, many who’ve stayed here say this property is a perfect balance of luxury and convenience. Boasting both a fitness center and spa, this hotel is determined to help you stay in shape. When it comes time to call it a day, settle down with a movie from the in room video checkout. Accommodations at the InterContinental Buckhead Atlanta feature a hint of Old World decor, but the amenities are up to date: Expect to find flat screen TVs and high speed Internet access (for a fee). Upgrade to a suite and you’ll be pampered by butler, turndown and valet service. This InterContinental hotel also impresses with its regional cuisine, served in an inviting atmosphere in the Southern Art Restaurant. And previous guests say the warmth can be found throughout the hotel thanks to its welcoming staff especially the front desk employees. Accommodations here are dressed in red and brown decor and come outfitted with pillow top mattresses, flat screen TVs and rainforest showers. Although the rooms are comfortable and a decent size, the rooftop lounge is the real highlight for most visitors you can enjoy excellent views of the riverfront while sipping delicious cocktails. But if you’re looking for that authentic “Southern charm” or resort style amenities, you should consider Bohemian’s sister hotel, The Mansion on Forsyth Park. If you do decide to stay at the Bohemian Hotel, you will have access to two fine restaurants: Rocks on the River specializes in American fare and Rocks on the Roof serves up tasty tapas plates. One perk of both hotels is that they’re Autograph Collection properties and part of the Marriott family. As such, Marriott Rewards loyalty program members can use points toward a stay here.