The Howard Hughes Medical Institute (HHMI), Bill & Melinda Gates Foundation, Wellcome Trust, and Calouste Gulbenkian Foundation have announced the International Research Scholars Program which aims to support up to 50 outstanding early career scientists worldwide. The program’s aim is to help develop scientific talent worldwide.

The new international competition is seeking top early career researchers from a wide variety of biomedical research fields. Applicants must have started their first independent research position on or after April 1, 2009. Awardees will be invited to participate in research meetings with scientists supported by the funders. These meetings facilitate the exchange of ideas, stimulate new research, and provide an opportunity for collaborative endeavors within the international scientific community.

HHMI and its partners have committed a total of $37.4 million for the International Research Scholars Program and will award each scientist who is selected a total of $650,000 over five years. The competition is open to scientists who have trained in the U.S. or United Kingdom for at least one year. Additionally, eligible scientists must have run their own labs for less than seven years, and work in one of the eligible countries.

Although Nieng Yan had several grants when she started her lab at Tsinghua University in 2007, she barely had enough money to pay her eight lab members. “In China, there is a limit on the percentage of a grant that you can use to pay people — your graduate students, your postdocs, your technicians, your assistants — to a decent level,” she explains. After struggling to balance her budget for several years, Yan’s scientific achievements and potential landed her an international grant from HHMI in 2012. “The amount of money provided by Hughes is relatively small compared to other programs, but it has the advantage that you can freely decide what to do with it,” says Yan. In fact, HHMI’s science officers encouraged Yan to use her five-year International Early Career Award (IECS) to cover the cost of paying her lab team, explaining that the money could be used in any way that assisted her research. Today, Yan has 15 people working in her lab helping to elucidate the structures of proteins that move molecules in and out of cells. The protein channels and transporters they study are mutated in a number of diseases — including diabetes and cancer — and understanding how they work could help in the development of drugs that block their ill effects. For example, the team recently solved the structure of GLUT1 – a glucose transporter that is often overexpressed in malignant tumor cells. Their data may provide clues for how to inhibit the transporter and perhaps even reveal a way to use it to deliver chemotherapeutic drugs. Photo Credit: Kevin Wolf (AP)

Countries that are not eligible for this competition include the G7 countries (Canada, France, Germany, Italy, Japan, United Kingdom and United States), as well as countries identified by the U.S. Department of Treasury, Office of Foreign Assets Control (OFAC) as being subject to comprehensive country or territory-wide sanctions or where current OFAC regulations prohibit U.S. persons or entities from engaging in the funding arrangements contemplated by this grant program. For this program, such sanctioned countries or territories currently include Iran, North Korea, Sudan, Syria, and the Crimea region of Ukraine.

Max Planck Research Group, Germany – “The Max Planck Society is committed to support Open Access on all levels. We therefore ask applicants to highlight in their list of publications all items which are freely available in an open access repository or on a journal’s website.”

Seeing what these kids come up with is so refreshing after being so disappointed by the actions fo our leaders (politicians, business leaders, financiers, law enforcement [spying on citizens because they feel electronic privacy is fine to invade, taking away liberty…], health care in the USA [twice as expensive as elsewhere with no better results, 10 of millions without coverage]…). These kids make me feel hopeful, unfortunately the actions of the powerful leave me less hopeful.

Jack Andraka created a new paper based test for diagnosing pancreatic cancer that is 50% more accurate, 400 times more sensitive, and 26,000 times less expensive than existing methods. His method uses carbon nanotubes and can catch the disease in very early stages which is critical to treatment success. The test also covers other forms of cancer very effectively (he concentrated on the results for pancreatic cancer given the low survival rates for that cancer). Jack Andraka: “I actually love single-walled carbon nanotubes; they’re like the superheroes of material science.”

His results are great. Often initial results can be difficult to actually turn into such positive results in the real world. But this is a great step and it is great to see what young minds can do. The claims for how much better, cheaper etc. are wildly different in various places on the International Science and Engineering Fair (ISEF) site.

Jack Andraka was awarded $75,000 for his development of a new method to detect pancreatic cancer as the winner of the top prize at the Intel ISEF (I believe it is new this year to call the winner the Gordon E. Moore Award).

As I have written previously the career prospects for engineers are bright around the globe. Many countries realize the importance of engineering and have taken steps to compete as a center of excellence for engineering. It is a smart economic policy. Ironically, the USA, that did such a great job at this in the 1960’s and 1970’s, has been falling down in this regard. A significant reason for this is the USA can only fund so many things and a broken health care system, military complex, bailouts to bankers (trust fund babies and others) cost a lot of money. You chose what to fund, and those are taking much of the available USA funds. There are also non-economic reasons, such as the turn in the last decade in the USA to make the barriers for foreigner engineers (and others) to go through to go to school, visit and stay in the USA have all increased dramatically.

Back to the prospects for engineers: their are shortages of good engineers all over (and the future projections don’t show any reason to believe this will change). Germany Faces a Shortage of Engineers:

In June, the Association of German Engineers (VDI) reported that there were 76 400 vacant engineering jobs—an all-time high.
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Policymakers in Berlin have responded to the shortage of skilled workers with a number of measures, including changes in immigration rules that allow German companies to hire engineers from other countries, including those outside of the European Union. Among them: The annual salary that companies must pay foreigners has been lowered from 60,000 Euro (US $95,000) to 40,000 Euro, which is roughly the starting salary of an engineering graduate in Germany…

To make it easy for engineers to move around Europe, engineering associations and other groups across Europe are working with the European Commission (the executive arm of the European Union) to launch the new Engineering Card. The card, which German engineers can apply for now and other countries are planning to launch, provides standardized information about the engineer’s qualifications and skills for greater transparency.
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“We don’t expect many engineers will come, because among other reasons, there is a shortage of engineers across Europe,”

15 finalists (from 3 different age groups – 13-14 years old, 15-16 and 17-18) were selected. 11 finalists were from the USA and 1 each from Singapore, Canada, India and South Africa. These examples of what can be done with imagination, effort and a scientific mindset is great.

The grand prize winner, Shree Boseer’s project:

Each year, over 21,000 women are diagnosed with ovariancancer – the 5th leading cause of cancer-related deaths in women in the United States. One of the most common drugs usedin ovarian cancer chemotherapy is cisplatin, a platinum-based chemotherapy treatment. While the drug affects ordinary cells, the significantly higher replication frequency of cancer cells causes cisplatin to have a greater impact in malignant cells. However, cancer cells often develop resistance to cisplatin, rendering the treatment ineffective. To improve the efficiency of cisplatin treatment, this research sought to determine whether AMP kinase, an energy protein of cell, plays a role in the development of cisplatin resistance. Studies with various techniques showed a significant difference on cell death caused by cisplatin insensitive and resistant ovarian cancer cells when AMPK was inhibited,suggesting that AMPK plays a role in the development of resistance. This work,in addition to offering a new treatment regime, also furthers our understanding of ovarian cancer and cancers in general.

This is a great project and the experience for the students is wonderful. Still I do think the prizes should be much larger given all the large corporations involved. Get involved with the next Google Science fair.

“We want medical, dental, and veterinary students to become immersed in the life of academic science for at least a year. And we hope they get so engaged in the process and life of scientific research that they will decide to continue it for the rest of their lives,” says Peter Bruns, HHMI’s vice president for grants and special programs. “We need more doctors who do basic research to improve human health.”

As part of its commitment to fostering the translation of basic research discoveries into improved diagnoses and treatments, HHMI has developed a range of programs to nurture the careers of researchers who bridge the gap between clinical medicine and basic science. In addition to the programs for medical students, the Institute supports medical training for Ph.D. students in the basic sciences and has made specific efforts to fund top physician-scientists as HHMI investigators.

The medical research scholars and fellows programs are open to medical, dental, and veterinary students enrolled in U.S. schools. Most have completed the second or third year of their professional program when they spend a year working in a lab either at the NIH or at an academic medical center or research university they select. During the last 25 years, more than 2,100 students have participated.

The HHMI Medical Research Fellowships program allows medical, dental, and veterinary students to pursue biomedical research at a laboratory anywhere in the United States except the NIH campus in Bethesda. Each student submits a research plan to work in a specific lab with a mentor they have identified. Since 1989, about 1,200 students have participated.

This year, 74 students from 26 medical schools and two veterinary schools were chosen as fellows from a pool of 274. While most students elect to stay at their home institution to do their research, this year 17 fellows will work in labs at a different school. Their research topics include schizophrenia, wound healing, organ development, and many other important biological questions.

The HHMI-NIH Research Scholars program was established in 1985 to encourage medical students to pursue research by allowing them to take a year off from their medical studies. The program has since been expanded to include dental and veterinary students. It has enabled about 1,000 students to work in NIH labs.

Students selected as research scholars often enter the program with only a general idea of what type of research they would like to do. As soon as they are accepted, they begin researching the more than 1,100 laboratories at NIH. They meet with a number potential mentors before finalizing which project to pursue under the guidance of their NIH advisor and HHMI’s staff. The students are sometimes called “cloister scholars” because they live in apartments or dorm-style rooms in a refurbished cloister on the NIH campus in Bethesda.

Fellows will be selected competitively by each organization. Each fellowship will have a three-year term. When the initiative is at full capacity, HHMI will be supporting 96 postdoctoral fellows at an anticipated annual cost of about $5 million. The program began in 2007 when HHMI announced it would fund up to 16 postdoctoral fellows in HHMI labs each year. There is no requirement that future fellows be appointed in HHMI labs.

It’s been a year since Rutgers University launched one of the country’s most ambitious education experiments, a campaign to change the fortunes of urban teenagers
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Adolescents, their parents and public school administrators uniformly praise the Future Scholars Program. Last June, the initiative started 200 disadvantaged seventh-graders along a five-year path of summer workshops, tutoring, social support and cultural outings. Their reward if they keep a B average and meet other requirements: a full ride to Rutgers.

The goal of the Rutgers Future Scholars program is to increase the numbers of academically ambitious high school graduates who come from low-income backgrounds, help them meet the standards to be admitted to colleges and universities, and then provide tuition funding to those who are admitted and choose to attend Rutgers University.

Most students don’t conduct stem-cell research and sit on a national board with a $3 million budget. Tej Nuthulaganti isn’t like most students.

After earning his undergraduate degree in biology from Rutgers-Camden in 2007, Tej is on track to earn his graduate degree in biology this May, thanks to the five-year combined bachelor and master degree program in biology at Rutgers-Camden.
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For the past two years the 2003 graduate of Highland High School has been working with Daniel Shain, an associate professor of biology at Rutgers-Camden and one of the nation’s leading experts on leech research. Nuthulaganti has furthered Shain’s research on identifying key genes that are pivotal in the stem cell formation in the leech, which gives a simple model system for more complicated research. Their research could be beneficial in the early detection of cancerous cells.

In addition to presenting his research at major conferences, including one at the University of California-Berkeley, Nuthulaganti has also made sure that his fellow students who are considering careers in medicine also have a forum to ask questions and think deeply about what kinds of doctors they’d like to be.

There are many great programs underway that are aimed at improving education performance. And this seems like another good effort.

Tara Adiseshan, 14, of Charlottesville, Virginia; Li Boynton, 17, of Houston; and Olivia Schwob, 16, of Boston were selected from 1,563 young scientists from 56 countries, regions and territories for their commitment to innovation and science. Each received a $50,000 scholarship from the Intel Foundation.

In the webcast, Tara Adiseshan, talks about her project studying the evolutionary ties between nematodes (parasites) and sweat bees. She identified and classified the evolutionary relationships between sweat bees and the nematodes (microscopic worms) that live inside them. Tara was able to prove that because the two have such ecologically intimate relationships, they also have an evolutionary relationship. That is to say, if one species evolves, the other will follow.

Li Boynton developed a biosensor from bioluminescent bacteria (a living organism that gives off light) to detect the presence of contaminants in public water. Li’s biosensor is cheaper and easier to use than current biosensors, and she hopes it can be used in developing countries to reduce water toxicity.

Olivia Schwob isolated a gene that can be used to improve the intelligence of a worm. The results could help us better understand how humans learn and even prevent, treat and cure mental disabilities in the future.

In addition to the three $50,000 top winners, more than 500 Intel International Science and Engineering Fair participants received scholarships and prizes for their groundbreaking work. Intel awards included 19 “Best of Category” winners who each received a $5,000 Intel scholarship and a new laptop. In total, nearly $4 million is scholarships and awards were provided.

Due to the complexity of the current budget situation, the 2009 GRFP awards will be announced in installments based on fields of study and other factors. The first installment is now available on FastLane. Awardees, as well as Applicants not recommended for funding, have been notified by email. Recipients of Honorable Mention and any additional Fellowship award offers will be forthcoming. Applicant ratings sheets will be available after all award announcements have been made. We thank you for your patience.