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Researchers from the Lunenfeld-Tanenbaum Research Institute at Toronto's Mount Sinai Hospital report in Science this week that mitotic cells inhibit DNA double-strand break repair to prevent telomere fusions. They found that mitotic kinases phosphorylate the E3 ubiquitin ligase RNF8 as well as the non-homologous end-joining factor 53BP1 to prevent them from being recruited to DSB sites.