The first edition of this book was published in 1937 as a compendium of information about the effects on man and animals of various solvents used in industry. The revised edition summarizes more recent information on previously reviewed solvents and includes data on newer solvents that have come into use since the first edition was prepared. This edition reviews 126 different solvents grouped into 10 chapters under the following categories: hydrocarbons, chlorinated hydrocarbons, alcohols, ethers, esters, ketones, glycols and their derivatives, amino and coal tar bases, and nitrogen and miscellaneous compounds. Discussions of individual solvents cover properties, uses, acute and chronic toxicity to man and animals, lethal and narcotic doses and concentrations by various routes of administration and exposure, symptoms, and effects on the blood and internal organs. There are also data on estimation of the solvent in the atmosphere and in blood and tissues, manufacture, metabolism, differential diagnosis of