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City are balancing their efforts to make ground on Premier League leaders Liverpool with their ventures in the Champions League, the FA Cup and the Carabao Cup, and Guardiola insists the hectic schedule demands that the full complement of his squad will be used.

"It's important with the amount of games we have with no breaks and games every three days. Everyone is going to play, they know that," the City boss told Sky Sports. "We've already done it and we'll do it in the future."

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De Bruyne made his first Premier League start since recovering from the second of his knee ligament injuries this season, and Guardiola said he was delighted to have the Belgium international back.

"What we want is for him to be fit," he said. "He's fit, he's not injured anymore. He's training for the last month. He's played in the other competitions and we decided today to put him inside. Of course, we know the quality that he has."

Aguero has netted 14 goals in 23 appearances for City this season, but Guardiola insists the Argentine is interchangeable with 21-year-old Jesus.

"It's the same argument," Guardiola explained. "When we don't play Sergio we can play Gabriel and when we don't play Gabriel we can play Sergio.

"When we play every three days and after three days another one and after three days another one and after on Tuesday against Newcastle. Everyone is going to play.

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"It's the same with John Stones today who doesn't play and Bernardo Silva, he's played a lot of games. Everybody has to play. If you don't it's impossible to sustain this amount of games. We need everybody."

Liverpool secured a dramatic 4-3 victory over Crystal Palace to extend their lead at the top of the table to seven points, and Guardiola joked that he hopes the TV scheduling will allow the Blues to play before Jurgen Klopp's side at some stage this season.

"It is what it is," he said. "Maybe one day we'll play before. If the TVs decide! I've said many times, we have to play our games. We can't get involved with what the other opponents do. Try to win our games is all we can do."