Medical Xpress news tagged with:childhood leukemiahttp://medicalxpress.com/
en-usMedical Xpress internet news portal provides the latest news on science including: Physics, Nanotechnology, Life Sciences, Space Science, Earth Science, Environment, Health and Medicine.Genetic hallmarks of acute lymphoblastic leukemia subtype uncoveredAn international team of researchers from the St. Jude Children's Research Hospital - Washington University Pediatric Cancer Genome Project (PCGP) and the Children's Oncology Group (COG) has identified the genetic changes that underpin a subtype of the most common cancer found in children. This form of B-precursor acute lymphoblastic leukemia (B-ALL) features genetic changes to two transcription factors known as DUX4 and ERG, proteins that closely control the activities of other crucial genes in human blood cells. The findings are published online today in the journal Nature Genetics.http://medicalxpress.com/news/2016-10-genetic-hallmarks-acute-lymphoblastic-leukemia.html
GeneticsMon, 24 Oct 2016 11:10:01 ESTnews395914683For some cancers, risk lower among kids of non-US-born Hispanic mothersThe children of Hispanic mothers not born in the United States appeared to have a lower risk for some types of childhood cancers, according to an article published online by JAMA Pediatrics.http://medicalxpress.com/news/2016-04-cancers-kids-non-us-born-hispanic-mothers.html
CancerMon, 25 Apr 2016 11:00:06 ESTnews380797412Attention problems persist in childhood leukemia survivors treated with chemotherapy alonePediatric acute lymphoblastic leukemia (ALL) patients treated with chemotherapy alone remain at risk for attention and learning problems that persist after treatment ends, according to St. Jude Children's Research Hospital investigators. The research appears online this week in the Journal of Clinical Oncology.http://medicalxpress.com/news/2016-02-attention-problems-persist-childhood-leukemia.html
CancerWed, 10 Feb 2016 09:50:26 ESTnews374320225Inherited gene variation linked to an increased risk of the most common childhood cancerResearchers studying two generations of a family affected by pediatric acute lymphoblastic leukemia (ALL) have identified an inherited variation in the ETV6 gene that is associated with an increased risk of developing the disease. St. Jude Children's Research Hospital investigators led the study, which appears in the October 28 issue of the journal Lancet Oncology.http://medicalxpress.com/news/2015-10-inherited-gene-variation-linked-common.html
CancerTue, 27 Oct 2015 18:30:03 ESTnews365175479Home pesticide use tied to child cancer risk(HealthDay)—Children exposed to insecticides at home may have a slightly increased risk of developing leukemia or lymphoma, a new review finds.http://medicalxpress.com/news/2015-09-home-pesticide-tied-child-cancer.html
CancerMon, 14 Sep 2015 11:48:26 ESTnews361450097Study suggests breastfeeding may lower risk of childhood leukemiaBreastfeeding for six months or longer was associated with a lower risk of childhood leukemia compared with children who were never breastfed or who were breastfed for a shorter time, according to an article published online by JAMA Pediatrics.http://medicalxpress.com/news/2015-06-breastfeeding-childhood-leukemia.html
PediatricsMon, 01 Jun 2015 11:00:02 ESTnews352367696Cancer treatments got gentler, yet kids' survival improvedThe move to make cancer treatments gentler for children has paid a double dividend: More kids are surviving than ever before, and without the long-term complications that doomed many of their peers a generation ago, new research shows.http://medicalxpress.com/news/2015-06-cancer-treatments-gentler-kids-survival.html
CancerMon, 01 Jun 2015 02:44:36 ESTnews352345469Study explains how early childhood vaccination reduces leukemia riskA team led by UCSF researchers has discovered how a commonly administered vaccine protects against acute lymphoblastic leukemia (ALL), the most common type of childhood cancer.http://medicalxpress.com/news/2015-05-early-childhood-vaccination-leukemia.html
ImmunologyMon, 18 May 2015 11:00:03 ESTnews351164815Researchers report success in mitigating treatment-related side effects in childhood leukemiaTen-year-old Matty Hayes is among the 90 percent of kids who are still alive five years after being treated for leukemia. But he's also among the 60 percent who suffer severe side effects from the intense chemotherapy that saves their lives.http://medicalxpress.com/news/2015-05-success-mitigating-treatment-related-side-effects.html
Medical researchThu, 07 May 2015 08:38:05 ESTnews350206673Study pinpoints genetic cause of increased leukemia riskA University of Colorado Cancer Center study published today in the journal Nature Genetics describes a newly-discovered, heritable genetic cause of acute lymphoblastic leukemia (ALL), namely mutation of the gene ETV6. Much like mutation of the gene BRCA marks people at risk to develop breast and ovarian cancers, identification of mutations in the gene ETV6 may allow doctors to predict the development of ALL, allowing increased monitoring and in the future, perhaps strategies to prevent the disease. There are just over 30,000 cases of ALL diagnosed in the United States each year, with the majority of those cases being in children ages 2-5.http://medicalxpress.com/news/2015-03-genetic-leukemia.html
GeneticsWed, 25 Mar 2015 14:00:07 ESTnews346487866Researchers engineer a 'smart bomb' to attack childhood leukemiaFatih Uckun, Jianjun Cheng and their colleagues have taken the first steps towards developing a so-called "smart bomb" to attack the most common and deadly form of childhood cancer—called B-lineage acute lymphoblastic leukemia (ALL).http://medicalxpress.com/news/2014-11-smart-childhood-leukemia.html
CancerWed, 05 Nov 2014 09:42:10 ESTnews334402894Genomic analysis reveals that a high-risk leukemia subtype becomes more common with ageMore than one-quarter of young adults with the most common form of acute lymphoblastic leukemia (ALL) have a high-risk subtype with a poor prognosis and may benefit from drugs widely used to treat other types of leukemia that are more common in adults, according to multi-institutional research led by St. Jude Children's Research Hospital investigators. The study appears in the current issue of The New England Journal of Medicine.http://medicalxpress.com/news/2014-09-genomic-analysis-reveals-high-risk-leukemia.html
CancerWed, 10 Sep 2014 17:00:03 ESTnews329579997Novel target found for chemotherapy-resistant leukemia cellsResearchers at Children's Hospital Los Angeles have discovered that by targeting a particular receptor, chemotherapy-resistant cancer cells can be killed in an acute form of childhood leukemia, offering the potential for a future treatment for patients who would otherwise experience relapse of their disease.http://medicalxpress.com/news/2014-05-chemotherapy-resistant-leukemia-cells.html
CancerTue, 13 May 2014 04:29:55 ESTnews319174184Study shows promise of preserving fertility in boys with cancerScientists have moved a step closer to being able to preserve fertility in young boys who undergo chemotherapy and radiation treatments for cancer. The new research, published in Fertility and Sterility, the journal of the American Society for Reproductive Medicine, addresses the safety of an option scientists are developing for boys who aren't sexually mature and cannot bank sperm.http://medicalxpress.com/news/2014-03-fertility-boys-cancer.html
CancerThu, 27 Mar 2014 14:44:40 ESTnews315150266Review: Coffee in pregnancy tied to childhood leukemia risk(HealthDay)—Maternal coffee consumption during pregnancy is associated with increased risk of childhood acute leukemia (AL), according to a meta-analysis published in the February issue of the American Journal of Obstetrics & Gynecology.http://medicalxpress.com/news/2014-02-coffee-pregnancy-tied-childhood-leukemia.html
Obstetrics & gynaecologyFri, 07 Feb 2014 10:20:02 ESTnews310988007A father and daughter's race to beat leukemia(HealthDay)—Bruce Cleland has vivid memories of the day in 1986 when he learned that his daughter Georgia, then 2, had been diagnosed with the most common form of childhood leukemia.http://medicalxpress.com/news/2013-11-father-daughter-leukemia.html
CancerFri, 01 Nov 2013 14:10:01 ESTnews302532883Inherited gene variation tied to high-risk pediatric leukemia and greater risk of relapseResearch led by St. Jude Children's Research Hospital scientists has linked an inherited gene variation to a nearly four-fold increased risk of developing a pediatric acute lymphoblastic leukemia (ALL) subtype that is associated with a poor outcome. The study appears today in the online edition of the scientific journal Nature Genetics.http://medicalxpress.com/news/2013-10-inherited-gene-variation-tied-high-risk.html
GeneticsSun, 20 Oct 2013 13:00:17 ESTnews301492276Researchers uncover genetic cause of childhood leukemiaFor the first time, a genetic link specific to risk of childhood leukemia has been identified, according to a team of researchers from Memorial Sloan-Kettering Cancer Center, St. Jude Children's Research Hospital, University of Washington, and other institutions. The discovery was reported online today in the journal Nature Genetics.http://medicalxpress.com/news/2013-09-uncover-genetic-childhood-leukemia.html
CancerSun, 08 Sep 2013 13:00:01 ESTnews297862643Epigenetic factor likely plays a key role in fueling most common childhood cancer(Medical Xpress)—Changes in an epigenetic mechanism that turns expression of genes on and off may be as important as genetic alterations in causing pediatric acute lymphoblastic leukemia (ALL), according to a study led by scientists at St. Jude Children's Research Hospital and published in the June 10 online edition of the Journal of Clinical Investigation.http://medicalxpress.com/news/2013-06-epigenetic-factor-key-role-fueling.html
CancerMon, 10 Jun 2013 13:33:41 ESTnews290090014Researchers discover normal molecular pathway affected in poor-prognosis childhood leukemiaThrough genetic engineering of laboratory models, researchers at Dartmouth-Hitchcock Norris Cotton Cancer Center have uncovered a vulnerability in the way cancer cells diverge from normal regenerating cells that may help treat children with leukemia as reported in the journal PNAS on June 3, 2013. Dartmouth researchers are trying to understand the key pathways that distinguish how a normal blood cell grows and divides compared to the altered growth that occurs in leukemia. In addition to the treatment of leukemia, the work has relevance for expanding umbilical cord blood or bone marrow stem cells for transplantation.http://medicalxpress.com/news/2013-06-molecular-pathway-affected-poor-prognosis-childhood.html
CancerThu, 06 Jun 2013 17:03:05 ESTnews289756946Study finds potential link between auto pollution, some childhood cancersScientists from UCLA's Fielding School of Public Health led by Julia Heck, an assistant researcher in the school's epidemiology department and a member of UCLA's Jonsson Comprehensive Cancer Center, have found a possible link between exposure to traffic-related air pollution and several childhood cancers.http://medicalxpress.com/news/2013-04-potential-link-auto-pollution-childhood.html
CancerTue, 09 Apr 2013 13:37:30 ESTnews284733441Immunotherapy showed promising antileukemia activity in pediatric patientsResearchers using patients' own immune cells in an immunotherapy approach called "anti-CD19 chimeric antigen receptor (CAR) T-cell therapy," achieved responses in children whose acute lymphocytic leukemia (ALL) had returned after a bone marrow transplant, according to preliminary results presented at the AACR Annual Meeting 2013, held in Washington, D.C., April 6-10.http://medicalxpress.com/news/2013-04-immunotherapy-antileukemia-pediatric-patients.html
CancerSun, 07 Apr 2013 17:14:23 ESTnews284573651T-cell therapy eradicates an aggressive leukemia in two childrenTwo children with an aggressive form of childhood leukemia had a complete remission of their disease-showing no evidence of cancer cells in their bodies-after treatment with a novel cell therapy that reprogrammed their immune cells to rapidly multiply and destroy leukemia cells. A research team from The Children's Hospital of Philadelphia and the University of Pennsylvania published the case report of two pediatric patients Online First today in The New England Journal of Medicine. It will appear in the April 18 print issue.http://medicalxpress.com/news/2013-03-t-cell-therapy-eradicates-aggressive-leukemia.html
CancerMon, 25 Mar 2013 12:30:33 ESTnews283433425Study finds mutations linked to relapse of childhood leukemiaAfter an intensive three-year hunt through the genome, medical researchers have pinpointed mutations that leads to drug resistance and relapse in the most common type of childhood cancer—the first time anyone has linked the disease's reemergence to specific genetic anomalies.http://medicalxpress.com/news/2013-02-mutations-linked-relapse-childhood-leukemia.html
GeneticsSun, 03 Feb 2013 13:00:04 ESTnews279114848Study finds new genetic defects in high-risk childhood leukemia subtypes with chromosomal lossResearch led by St. Jude Children's Research Hospital scientists has identified a possible lead in treatment of two childhood leukemia subtypes known for their dramatic loss of chromosomes and poor treatment outcomes.http://medicalxpress.com/news/2013-01-genetic-basis-high-risk-childhood-cancer.html
GeneticsSun, 20 Jan 2013 13:00:01 ESTnews277901054Engineered immune cells produce complete response in child with an aggressive pediatric leukemiaBy reprogramming a 7-year-old girl's own immune cells to attack an aggressive form of childhood leukemia, a pediatric oncologist has achieved a complete response in his patient, who faced grim prospects when she relapsed after conventional treatment. The innovative experimental therapy used bioengineered T cells, custom-designed to multiply rapidly in the patient, and then destroy leukemia cells. After the treatment, the child's doctors found that she had no evidence of cancer.http://medicalxpress.com/news/2012-12-immune-cells-response-child-aggressive.html
CancerSun, 09 Dec 2012 23:50:01 ESTnews274318776Nanotechnology drug delivery shows promise for treatment of pediatric cancerThis month, Molecular Pharmaceutics reported promising findings from the Nemours Center for Childhood Cancer Research and the Materials Science and Engineering Department at the University of Delaware, about the potential for nanotechnology to deliver chemotherapeutic agents in a way that attacks cancer cells without harming healthy cells. To date, nanoparticle-based drug delivery approaches have been poorly developed for the treatment of childhood leukemia, which comprises 30% of childhood cancers. In the Nemours study, encapsulated dexamethasone ("dex") delivered to pre-clinical models with leukemia significantly improved quality of life and survival compared to the control receiving the unencapsulated drug.http://medicalxpress.com/news/2012-12-nanotechnology-drug-delivery-treatment-pediatric.html
CancerTue, 04 Dec 2012 12:06:07 ESTnews273845157Gene sequencing project identifies abnormal gene that launches rare childhood leukemiaResearch led by the St. Jude Children's Research Hospital – Washington University Pediatric Cancer Genome Project has identified a fusion gene responsible for almost 30 percent of a rare subtype of childhood leukemia with an extremely poor prognosis.http://medicalxpress.com/news/2012-11-gene-sequencing-abnormal-rare-childhood.html
CancerMon, 12 Nov 2012 13:39:30 ESTnews271949948Scientific progress could be casualty in public health vs. privacy debate over newborn blood samplesThe tremendous potential public health benefits of research with blood samples left over after routine newborn screening must not be lost amidst controversy and litigation, say medical and bioethics experts in a commentary published in the journal Science Translational Medicine.http://medicalxpress.com/news/2012-11-scientific-casualty-health-privacy-debate.html
OtherWed, 07 Nov 2012 14:00:09 ESTnews271508304Improved diagnostic test benefits children with acute myeloid leukemiaEarly treatment response is a powerful predictor of long-term outcome for young patients with acute myeloid leukemia (AML). The information can help physicians decide whether a more intensive approach is needed. Research led by St. Jude Children's Research Hospital investigators has identified the best test for measuring that response and guiding therapy.http://medicalxpress.com/news/2012-09-diagnostic-benefits-children-acute-myeloid.html
CancerMon, 10 Sep 2012 16:50:48 ESTnews266514612