..This controlled bias away from negative social stimuli in deluded schizophrenia is discussed in terms of an attentional style of 'vigilance-avoidance' operating across early and late stages of information processing...

..In view of the evidence for working memory dysfunction as a candidate intermediate phenotype for both disorders, we explored neuroanatomical distinctions between subtypes defined according to working memory (n-back task) performance...

Network dysfunction of emotional and cognitive processes in those at genetic risk of bipolar disorder

..We thus establish a specific network disturbance suggesting dysfunction in the processes that support hierarchical relationships between emotion and cognitive control in those at high genetic risk for bipolar disorder. ..

Do common genotypes of FK506 binding protein 5 (FKBP5) moderate the effects of childhood maltreatment on cognition in schizophrenia and healthy controls?

..These results suggest that cortisol responses may normalize with medication (in SZ) and longer illness duration (in BD), in line with findings of aberrant cortisol levels in the early stages of psychotic disorders. ..

Task-related fronto-striatal functional connectivity during working memory performance in schizophrenia

Yann QuidéSchizophrenia Research Institute, Darlinghurst, NSW, Australia School of Psychiatry, University of New South Wales, Randwick, NSW, AustraliaSchizophr Res 150:468-75. 2013

Common or distinct pathways to psychosis? A systematic review of evidence from prospective studies for developmental risk factors and antecedents of the schizophrenia spectrum disorders and affective psychoses

Kristin R LaurensResearch Unit for Schizophrenia Epidemiology, School of Psychiatry, University of New South Wales, Sydney, AustraliaBMC Psychiatry 15:205. 2015

..This systematic review synthesises the available evidence concerning developmental risk factors and antecedents of SSD and AP to identify those with the most robust support, and to highlight remaining evidence gaps...

Systematic meta-analysis of insula volume in schizophrenia

Alana M ShepherdUniversity of New South Wales Research Unit for Schizophrenia Epidemiology, School of Psychiatry, Sydney, AustraliaBiol Psychiatry 72:775-84. 2012

..We provide the first meta-analysis of studies that conducted region-of-interest analyses of the magnitude of effect and pattern of insula volume reduction in schizophrenia compared with healthy control subjects...

Ian C GouldSchizophrenia Research Institute, Darlinghurst, NSW, Australia School of Psychiatry, University of New South Wales, AustraliaNeuroimage Clin 6:229-36. 2014

..Consideration of sex-specific differences in brain organization is thus likely to assist future attempts to distinguish subgroups of schizophrenia patients on the basis of neuroanatomical features. ..

Reduced inferior frontal gyrus activation during response inhibition to emotional stimuli in youth at high risk of bipolar disorder

Gloria RobertsSchool of Psychiatry, University of New South Wales, NSW, AustraliaBiol Psychiatry 74:55-61. 2013

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Systematic meta-review and quality assessment of the structural brain alterations in schizophrenia

New South Wales Child Development Study (NSW-CDS): an Australian multiagency, multigenerational, longitudinal record linkage study

Vaughan J CarrSchool of Psychiatry, University of New South Wales, Sydney, New South Wales, Australia Schizophrenia Research Institute, Sydney, New South Wales, Australia Department of Psychiatry, Monash University, Melbourne, Victoria, AustraliaBMJ Open 6:e009023. 2016

..The research will assist in informing the development of public policy and intervention guidelines to help prevent or mitigate adverse long-term health and social outcomes...

..Heightened levels of morning cortisol in SZ and BD suggest long-term pathology of the hypothalamic-pituitary-adrenal (HPA) axis that may reflect a shared process of illness development in line with current stress-vulnerability models. ..