This is a lecture/discussion course that covers systems physiology and relates these concepts to disease. The course is divided into several organ systems starting with an in depth discussion of the normal physiology of each system, that in turn sets the foundation for understanding the pathophysiology of each system. Included are discussions of cardiovascular, pulmonary, renal, gastro-intestinal, bone, and endocrine systems in the context of normal function, as well as the effect and consequences of representative pathophysiological conditions. This is a team taught course with a total of 24 formal lectures. There will be three non-cumulative exams each covering approximately one third of the course. Each exam will count for approximately one third of the total grade.