This conference was sponsored by the Josiah Macy, Jr., Foundation in the realization that the subject of cold injury overlaps a number of different disciplines in the general area of medicine. The topics discussed covered "Animal Studies," by Harris B. Shumacker Jr. and Jefferson M. Crismon; "Homeokinesis," by Steven M. Horvath; "Hypothermia," by John H. Talbott, with an additional report of experimental work in England by Otto G. Edholm. The conference concluded with a report on studies of "Acclimatization," by Robert Kark. These discussions are stimulating and will be of interest to many physicians.