"I saw two people go down on the floor and get ... handcuffed and dragged out of here," one witness, a passenger who was not named in the report, told WSVN.

Another passenger said he saw officers apprehending a woman.

In a statement, Spirit blamed the cancellations on the Airline Pilots Association. The airline claims some Spirit pilots are engaging in "unlawful labor activity" in order to disrupt operations. The low-cost carrier has filed a Federal lawsuit against the union.

The Airline Pilots Association did not immediately respond to the request from ABC News for a comment.

ABC News' Matt Foster and Andrew Evans contributed to this report. The Associated Press also contributed to this report.