So - first of all the official line is that the LD-client has NOT been tested for clustering purposes. Therefor you're a bit "on your own" here, so tread with caution accordingly.

Secondly - a lot depends on the details of just what sort of cluster you're talking here. There's fail-over clusters, load-balancing clusters, application-level clusters, and so on ... it's a bit of a "catch all" so specifying this would help here.

That said, I'll happily admit I'm not that heavy into clustering, so the below is "to the best of my knowledge" so that you have at least "some" answer, in case no one else is going to volunteer anything here .

Since LANDesk only cares (and "sees") "its client", so at this point the details will vary on the exact nature of your cluster, how it behaves.

The most definitive thing that I would suggest is that you test this really thoroughly (I'm hoping / assuming you've got a test environment) and observe, since a lot of this will come down to the exact nature of your cluster that you're talking about (and the nature of the software you're trying to install).