Aminoglycosides

Mode of action:

Inhibition of protein synthesis. Once inside the bacterial
cell, aminoglycosides bind to the 30s ribosomal sub-unit and cause a
misreading of the genetic code. This subsequently leads to the
interruption of normal bacterial protein synthesis.

Example:

Gentamicin, tobramycin, amikacin, streptomycin, kanamycin

Source:

Streptomyces spp.

Microsmonospora spp.

Spectrum of activity:

Broad spectrum but NOT effective against anaerobic bacteria

Effect on bacteria:

Bactericidal (dose dependent)

Examples of applications in Veterinary
Medicine:

Due to its toxicity, aminoglycoside use has been clinically limited
to severe infections. The more toxic antibiotics in this class
have been restricted to topical or oral use for the treatment of
infections caused by Enterobacteriaceae. The less toxic aminoglycosedes
are used for parenteral treatment of severe sepsis caused by Gram
negative aerobes.