About 155 genera and 2000 species distributed primarily in the tropics and subtropics, poorly represented in the temperate regions. Of the 44 genera and 145 species present in China, one genus and 38 species are endemic, and nearly 95% of the taxa grow in the southern and southwestern portions of the country.

Fruit type is highly diversified in the family, and it is diagnostic of many genera. Genera 1-4 produce 1, 2-celled berries from a flower; genus 5 produces 2, 1-celled berries from a flower; 6 and 7 produce mostly fleshy follicles containing deeply indented seeds with ruminate endosperm; 8 has follicles and winged seeds; 9 produces follicles and seeds with 2 comas; 10-12 have follicles with globose seeds; 13-18 have drupes mostly with fleshy mesocarp; 19 has samaroid fruit; 20 has spiny capsules with seeds winged all around; and 21-44 have free or fused follicles and comose seeds. Double flowers are known only from cultivated forms of Nerium oleander, Tabernaemontana divaricata, and Wrightia religiosa.

Plants of the Apocynaceae are often poisonous and are rich in alkaloids or glycosides, especially in the seeds and latex. Some species are valuable sources of medicine, insecticides, fibers, and rubber.