Newsletter Xagena

Long-term risk of myocardial infarction and stroke in bipolar I disorder

The aim of the study was to estimate the risk of fatal and non-fatal myocardial infarction and stroke in patients with bipolar I disorder compared to people without bipolar I disorder.

Utilizing a records-linkage system spanning 30 years ( 1966-1996 ), a population-based cohort of 334 subjects with bipolar I disorder and 334 age and sex-matched referents from Olmsted County, Minnesota, U.S. was identified.
Longitudinal follow-up continued until incident myocardial infarction or stroke ( confirmed by board-certified cardiologist / neurologist ), death, or study end date ( December 31, 2013 ).

This study in a geographically defined region in the U.S. has demonstrated a significant increased risk of myocardial infarction or stroke in bipolar I disorder, which was no longer significant after adjustment for cardiovascular risk factors. ( Xagena )