To the Editor: Dr Zacharski and colleagues1 reported no significant association between reduction of iron stores by phlebotomy and all-cause mortality, or death plus nonfatal myocardial infarction and stroke, the primary and secondary end points of the study, respectively. In post hoc analyses, they found that age significantly interacted with their primary and secondary end points and concluded that “iron reduction appeared to improve outcome to a significantly greater extent in younger compared with older patients.”