Polyak Breast SAGE Anatomic Viewer

The laboratory of Dr. Kornelia Polyak has been analyzing the gene expression profiles (using SAGE) of individual cell types, including cells with progenitor properties, isolated from normal breast (NB) tissue, ductal carcinoma in situ (DCIS), and invasive ductal carcinoma (IDC), and metastatic tumors. The results have been published in Cancer Cell, 2004, 6:17-32 and Cancer Cell, 2007, 11:259-73. The CGAP Polyak Breast SAGE Anatomic Viewer visually displays the expression of a specific gene in the isolated cell types.

Stages of Tumor Progression

In the first row of images, the tissue structure and relative abundance and location of the various cell types is schematically represented for all four stages of tumor progression. The accompanying table below lists the cell types by histology and displays the expression levels of a specific gene in each one.