Indoneesiella echioides (or) Andrographis echioides (L) Nees is an important herb widely distributed in south India. This is commonly known as False Water willow. Indoneesiella echioides (L) Nees is a traditional Indian medicine; the whole plant is highly medicinal value such as the leaf juice of this plant is used to cure fever. The plant was extracted using n-hexane, chloroform, ethyl acetate, acetone, butanol, ethanol and methanol. The present study was to be determined the preliminary phytochemical screening, antioxidant and antimicrobial activities of Indoneesiella echioides (L) Nees leaves.