Research-Grade Leukocytes

Following collection of the platelet product using either the Trima Accel collection device, some of the leukocytes are returned to the donor. However, approximately 1.5x109 leukocytes remain in a special leukocyte capture chamber (LRS chamber) to prevent them from being collected in the platelet product following collection of a single unit plateletpheresis. Following collection of a double unit plateletpheresis, approximately 2.0x109 leukocytes remain in the chamber.

Mononuclear cells comprise the majority of cells in the chamber. Key Biologics aseptically salvages the LRS chambers following plateletpheresis procedures by heat-sealing the chamber’s ingress and egress tubing and separating the chamber from the tubing. A unique tracking number is adhered to the chamber to allow linkage to the collection procedure. The chambers with a small amount of connected tubing are provided to researchers.

If requested, Key Biologics’ staff will transfer the residual leukocytes into a blood product bag by flushing the chamber contents. The transfer bag is labeled with a unique tracking number and provided to researchers.

The chambers and the collected cell fractions are stored at room temperature pending shipment. In alignment with the intended use of the product and your requirements, chambers or flushed cells can be packaged and shipped on the date of collection for overnight delivery.

​Packaging and ShipmentIn alignment with the intended use of the product and the customer’s requirements, products are generally packaged and shipped on the date of collection for overnight delivery. Products are packaged in a manner that ensures maintenance of a temperature between 1°C and 10°C or between 20°C and 24°C during shipment at the customer’s discretion. Continuous temperature monitoring data tracking devices are available for use at the customer’s request.