Mass Effect 2 - Point of No Return

Following the mission on the derelict reaper, head to the galaxy map and use it. After a short conversation, you and the rest of your squad will leave the Normandy and soon after a quick scene will play.

After the scene ends, you will be in control of Joker. Follow the trail of lights on the floor into the tech lab and crawl down the hatch in the back right corner of the room. At the bottom another crew member will be waiting for you and will escort you for a bit, he won't last long though, so just try to ignore all the baddies and continue to follow the trail of lights on the floor. Enter the room at the back of the Medical Bay to watch a short scene. Afterwards, turn around and make your way down the next crawl space. At the bottom, continue to follow the red lights on the floor and ignore any enemies that you see. After heading through the first door, activate the console here to watch another scene.

Following Joker's heroics, the rest of the crew will return and as always, be intent on discussing their next course of action. During the following conversation, you will find out what your plans will be from here on out. But do not agree to leave immediately, instead you should tell your crew members to hang ten before chasing after the collector ship.

Note: This is Mass Effect 2's point of no return. If you use the relay now, youwill be unable to return until you have completed the game. So its good idea to save here!

Before continuing, if you haven't done so already I would recommend heading back down stairs into the medical bay and activate the Geth you rescued from the derelict reaper (if you kept it). After a short conversation you can talk it into joining your crew.

Another wothwhile undertaking is to speak to each and every crew member, and picking up each of their respective missions. Completing the missions for each member builds their loyalty towards you and also allows each of them to unlock an additional ability which was previously unusable - which will make taking down enemies much easier. Check out the loyalty missions guide below to find guides for each of them.

In addition, you really should upgrade your characters as much as possible check out the upgrade guide below for any you might have missed, and complete any exploration/task side missions still available for additional credits, resources and an upgrade or two.

You should also use this opportunity to fly to each of the hub worlds - The Citadel, Illium, Tuchunka and Omega to purchase all the research projects from the shops. In addition to the research projects you have found during previous missions, upgrading your characters as much as possible will help them survive the final mission.

If you havent already, you should upgrade the shields on the Normandy. To do this, you will need to complete your crew members' loyalty mission and then engage in conversation withthese two crew members as such:

Talk to Jacob > Investigate > [NORMANDY UPGRADES].

You should also talk to Garrus to upgrade the Normandy's weapon systems Garrus > Investigate >[NORMANDY UPGRADES]

without these upgrades, people will die in the coming mission.

When you are ready to continue, fly to the nearest mass relay and travel to the Omega Nebula.