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Prodigal Murderer

To beat Mistral on Hard difficulty or higher without taking damage is a real challenge. The idea is to stay close and keep attacking so the dwarf gekkos don't hurt you. Meanwhile, keep your eye on Mistral. She happens to have a very obvious movement when she is about to attack. But don't think that it's too easy. Carefully time all of the blocks or they will hit you.

An easy way to bring her life down is to have already beaten the game and have the following items equipped. When you beat the game, you recieve the HF Murasama Blade and the Infinity Wigs A and B. It is ideal to get the Murasama Blade (a.k.a. Sam's Blade) because it has a slightly better reach than the regular HF Blade, and it has increased damage. And of the two wigs, choose Infinity Wig B (Blue Wig). Wig B gives you infinite fuel cell energy, which means infinite Ripper Mode. These two together will boost your damage dealing potential by about 2x to 3x.

It will take a lot of strategy to take down Mistral, but one thing I found out that helped me to recieve the trophy/achievement is that you CAN restart at the last checkpoint if you recieve damage throughout the battle. There are two checkpoints that ease the challenge even more. One after Mistral grabs Raiden by the leg and he knocks her to the adjacent pipe, and one after Mistral breaks the pipe and you land on the ground floor.

If you're like me, you also struggled while trying to block or evade the gekkos when she throws multiple or even single ones. When she is out of reach and throws multipe gekkos, just stand as close as possible and she can't hit you. Just a side note, keep slicing while you are out of range to keep the gekkos from you. As for the single shots, even though they are always after you cut off her arms and weapon in blade mode, they are unbelievably fast and unexpected the most you can hope for is to time a block just right. But if you get hit, no biggie. Just restart the last checkpoint.

This is all I have, hope it helps and I'll post the other boss challenges later.