Applications/Dilutions

The purity of this protein is > 85% by SDS-PAGE. Molecular weight is 27.5 kDa (237aa)

Reactivity Notes

Human

Alternate Names for THAP1 Recombinant Protein

4833431A01Rik

dystonia 6, torsion (autosomal dominant)

DYT6

FLJ10477

MGC33014

nuclear proapoptotic factor

THAP domain containing, apoptosis associated protein 1

THAP domain protein 1

THAP domain-containing protein 1

Background

THAP domain-containing protein 1, also known as THAP1, is a 213 amino acid protein that localizes to the nucleoplasm and contains one THAPtype zinc finger, a conserved DNA-binding domain. It is a DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. THAP1 may also have pro-apoptopic activity by potentiating both serum-withdrawal and TNF-induced apoptosis. Recombinant human THAP1protein, fused to His-tag at N-terminus, was expressed in E.coli.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.