Principlism was first formalized as a moral decision-making
approach by the National Commission for the Protection of Human Subjects of Biomedical and Behavioral Research in a document called the Belmont Report on April 18, 1979. The article first discusses the Thalidomide Case and the Tuskegee Syphilis Trials as an examples of private enterprise violating informed consent, and then looks at how principlism can be used as a practical approach for ethical decision-making.