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Aside from Prezista which was mentioned (and which came out a year ago) Aptivus is also new (in the last 2 years) -- that's 10 PI's now so I'm not sure why they would want to glut the market.

However, these PI's are slightly different as they're better for people with PI resistance issues. As well, all of the new HIV meds that are non-PI like Isentress, Selzentry and Etravirine are also aimed at patients with multiple resistance issues.

I'm not sure why you want what seems "more of the same" -- the longer we all live the more resistance issues all of us will face, so these other class drugs are needed. Plus entire new classes, like Isentress is as an integrase inhibitor, will eventually (I assume) be used as more of a first line treatment once it's studied more, and could very well prove more effective and tolerable in terms of side effects than what we have now.

I'm not sure why you want what seems "more of the same" -- the longer we all live the more resistance issues all of us will face, so these other class drugs are needed. Plus entire new classes, like Isentress is as an integrase inhibitor, will eventually (I assume) be used as more of a first line treatment once it's studied more, and could very well prove more effective and tolerable in terms of side effects than what we have now.

It was not "wanting more of the same" -- it was curiousity as to why research seems to have stopped on this one type. I'm still learning and it seemed like a logical question I couldn't really find the answer for myself.

But I think you gave a pretty thorough hypothesis as to why and I appreciate it.