Jets RB Isaiah Crowell will be a game-time decision this Sunday against the Colts after the running back suffered an ankle injury and missed multiple practices this week.

The team will work out Crowell on Sunday morning and if he isn’t good to go, Todd Bowles said rookie running back Trenton Cannon would get more work.

As expected, cornerback Buster Skrine was officially ruled out after suffering a concussion in the Jets’ win over the Broncos. Wide receiver Charone Peake is also out with a hamstring injury.

Cornerback Trumaine Johnson, who missed the Broncos game with a quad injury, is doubtful to play in Week 6, as is linebacker Kevin Pierre-Louis, who has a foot injury. Safeties Marcus Maye (foot/ankle) and Doug Middleton (hamstring) are also questionable.

Luckily, defensive end Leonard Williams is good to go after missing Thursday’s practice with a sore back.

With both Skrine and Johnson on the shelf, Bowles said it will be “all hands on deck” for the Jets secondary. That means a lot more of Darryl Roberts, Parry Nickerson and even a little Juston Burris. Neither Roberts nor Nickerson had exceptional games against the Broncos wideouts.

It appears as though the Colts will be without both star wide receiver T.Y. Hilton and starting tight end Jack Doyle for a second straight week. Along with Hilton and Doyle, Colts head coach Frank Reich ruled out offensive tackle Denzelle Good and a couple of defensive lineman for the game.