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Myotis is a more serious side effect of statins, as WebMD explains. This condition inflames the muscles and increases the chance of them being injured. This is especially true if the patient takes another medication, such as a fibrate, with the statin.

Rhabdomyolysis is extreme inflammation of the muscles, notes WebMD. This condition causes muscles throughout the body to become weak and painful, and it causes them to release proteins that accumulate in the kidneys and damage them. This can lead to life-threatening kidney failure. Statins can also elevate levels of creatine kinase, which causes muscle pain, weakness and mild inflammation.