The World’s First Dengue Fever Vaccine Is Coming to 3 Countries

A third of the world’s population is at risk of contracting Dengue Fever, a miserable virus that’s a leading cause of illness and death in the tropics. Now, for the first time ever, three countries have approved a promising new vaccine.

Highlighted regions are at primary risk of dengue outbreaks. The red lines show the potential limits for year-round survival of Aedes aegypti mosquitoes. (Credit: NCAR/UCAR)

Frustratingly, there have never been any vaccines to prevent infection. But as Dina Fine Maron reports in Scientific American, there’s finally cause for hope. A new drug, called Dengvaxia, has been approved for use in three countries, namely Mexico, the Philippines, and Brazil.

The vaccine itself is a live virus comprised of a modified yellow fever virus. It’s genetically engineered to include genes that encode for dengue proteins and coaxes the body’s immune system into producing antibodies that fight all four forms of dengue (DEN-1, DEN-2, DEN-3, DEN-4). The vaccine was developed by the French pharmaceutical company Sanofi. As Maron points out, however, It’s not clear when inoculations will start—or at what price.

This meaningful breakthrough is the result of over two decades of work involving 25 clinical studies in 15 countries around the world. Over 40,000 volunteers worked on the project and some 29,000 volunteers received the vaccine. Other vaccinations are currently in development, but only Dengvaxia has been given the green light. Sanofi’s facilities in France are reportedly capable of producing 100 million vaccine doses annually.

“Approval of the first dengue vaccine is an important public health breakthrough with critical importance to our country, which bears the greatest dengue burden in Latin America,” noted Joao Bosco from Brazil’s Institute of Tropical Pathology and Public Health in a Sanofi statement. “The 2015 dengue outbreak is still very present in the minds of Brazilians so Dengvaxia’s approval is a most welcome addition to our ongoing dengue prevention efforts.”

Unfortunately, the vaccine isn’t perfect, nor is it for everyone. In clinical trials it proved effective for about 65-per cent of participants aged 9 to 16. It prevented 8 out of 10 hospitalisations and up to 93-per cent of severe dengue cases. Dengvaxia can only be used on people age nine to 45 years old who live in areas susceptible to dengue fever. Sadly, and as Maron points out, the vaccine appears to be the least effective among those who need it the most: children under six.

All that said, we don’t yet know how this news will affect those living in the United States. Cases of dengue have recently been reported in Hawaii, Florida, and Puerto Rico, so the CDC and FDA would be wise to keep a close eye on Dengvaxia and how its deployment—and its potential effectiveness—plays out in other parts of the world.