Several catalytic families of DNA enzymes (deoxyribozymes) have previously been isolated through the use of an in vitro selection technique in our laboratory. The activities of these deoxyribozymes appear to be dependent ...

This study explores the potential assimilatory sulfate reduction pathway in methanarcheon by investigating the gene product of the open reading frame Mj0066. We expressed and purified the gene product of Mj0066 of ...

Analysis of x-omics samples presents a significant challenge to analytical chemists. The complexity and diversity of x-omics samples make it difficult to determine or develop the right analytical approach. This dissertation ...

Conversion of lignocellulosic biomass to ethanol involves pretreatment of biomass materials to increase the accessibility of carbohydrates in lignocellulose for enzymatic hydrolysis prior to ethanol fermentation. The ...

Essential for continued growth of the biofuels industry is the need for continued development of rapid, robust, and accurate carbohydrate quantitation methods. As new feedstocks are identified and developed, understanding ...

Increased human cathepsin L activity is linked to invasive and metastatic cancers where it promotes degradation of the extracellular matrix. This major cysteine protease found in cell lysosomes and secreted from tissues, ...

Vascular disruption is an innovative method for treating cancer. By selectively altering the endothelial cells of tumor vasculature, the tumor can be destroyed by oxygen deprivation and starvation. The combretastatin ...

Five penta-substituted ferrocenes, each having one 11-SH-undecanoyl substituent,
have been prepared from 1,1′,3,3′-tetra-t-alkylferrocenes and attached as electrochemically-assembled monolayers to gold electrodes (t-alkyl ...

Human cathepsins L and K are cysteine proteases that play important roles in physiological and pathological processes, such as cancer metastasis, bone resorption and neurodegenerative diseases. This research has focused ...

The unimolecular decomposition kinetics of jet-cooled cluster ions have been monitored over ranges of internal energies. The clusters are formed by the combination of Ni cation with and organic ketone, aldehyde or ether ...

Interest in the design and synthesis of supramolecular metal-organic coordination polymers has increased exponentially in the last decade. This attraction comes along with advances in crystallographic instrumentation that ...

The goal of the primary project was to explore further means of meniscal repair through application of the immobilization techniques previously developed by our research group. The menisci are susceptible to tears due to ...

Reaction rate constants have been acquired for the transition metal ion assisted decomposition of various organic molecules, and their deuterium labeled analogs in the gas phase. The metal ion activates organic bonds and ...

γ-Glutamylamine cyclotransferase (γ-GACT) catalyzes cyclization of the L-glutamyl moiety in the isolated ε-(L-γ-glutamyl)-L-lysine crosslink, thereby releasing lysine. Although implicated in the degradation of the crosslink, ...

One of the main goals of the primary project was to develop methods to site specifically immobilize functional proteins on a tissue surface. There are many examples of proteins that have been chemically modified and ...

The family of hetero-substituted maltol chelators, thiomaltol (Htma), dithiomaltol (Httma), and 3-hydroxypyridine-4-thione (Hopto) have been used to generate complexes with Ru(II), Pt(II), Ti(IV), and P(III) that exhibit ...

Post-mortem interval (PMI) is the time elapsed since a person died. Currently there is no accurate method for determining PMI of skeletal remains. Existing methods are best suited for deciding whether a bone is of forensic ...

Polarimetry and spectropolarimetry are important tools in the sugar industry and pharmaceutical research. Polarimetric measurements cannot be performed on colored samples because the presence of color interferes with the ...