5-hydroxytryptophan weight loss supplements

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WEIGHT LOSS PILL TYPE: Amino acid. 5-hydroxytryptophan is a chemical precursor (something that precedes another) of the neurotransmitter serotonin. The supplement 5-hydroxytryptophan is a derivative of the African plant Griffonia simplicifolia , which grows in the Ivory Coast and Ghana. The body produces 5-hydroxytryptophan from the amino acid tryptophan, which can be located in certain foods, including almonds, turkey, and cheese.

BACKGROUND/RESEARCH: Studies of 5-hydroxytryptophan for losing fat were first carried out in animals in 1975. In those days, researchers discovered that feeding 5-hydroxytryptophan to rats that were bred to overeat triggered these to eat far less food compared to tey normally ate. These reports led researchers to theorize that some individuals may be genetically predisposed to obesity as they have a diminished capability to convert tryptophan to 5-hydroxytryptophan which leads to low levels of another substance, called serotonin. Low levels of serotonin are related to obesity along with depression.

After the animal studies, three placebo-controlled, doubleblind studies in individuals were conducted in Rome, Italy, which demonstrated the benefits of 5-hydroxytryptophan.

One study included twenty obese women who were advised to not diet while they received either 5-hydroxytryptophan or placebo for 6 weeks. Then they were placed on a diet (1,200 calories per day) for 6 weeks while continuing to take 5- HTP or placebo. Females who had taken 5-hydroxytryptophan reduced their calorie consumption through the first 6 weeks and decreased their carbohydrate intake by 50 percent. In the second 6-week period, they decreased both their caloric and carbohydrate intake all the more. The women who had taken placebos showed hardly any reduction in calorie consumption, even if instructed to diet during the second 6-week period. These bits of information suggest that 5-hydroxytryptophan decreases yearnings for carbohydrates and thus the amount of calories consumed. An additional study of nineteen women had comparable results: women taking 5-hydroxytryptophan lost weight, even when they didn’t limit their calorie consumption.

WHAT IS IT SUPPOSED TO DO: Scientists believe that 5-hydroxytryptophan may be good at weight loss since it is able to chemically “trick” your brain into thinking you are full whenever you begin to eat, so that you are more unlikely to overeat and you will take in fewer calories. This principle is assigned to the idea that some individuals have a genetically caused decreased ability to convert tryptophan to 5-hydroxytryptophan which leads to their having decreased levels of the hormone serotonin. Low serotonin levels are related to obesity; research indicates that low amounts of this neurotransmitter produce cravings for carbohydrates that can be mild to severe. If you take supplements of 5-hydroxytryptophan, the body’s inability to convert tryptophan is bypassed, more serotonin is created, and the cravings subside.

HOW TO TAKE IT: Usually, manufacturers suggest taking 50 to 100 mg 5-hydroxytryptophan about 20 minutes before meals during the first 2 weeks. The dosage can be doubled if weight reduction is less than 1 pound per week after that time. 5-hydroxytryptophan should always be taken with a sufficient amount of vitamin B6 and zinc (a minimum of the suggested daily intake) since these nutrients help make the 5-hydroxytryptophan more accessible to the body, A high-quality multivitamin-mineral that supplies at least 25 mg vitamin B6 and 15 mg zinc is enough.

SIDE EFFECTS: Some individuals encounter mild nausea, heartburn, flatulence, and a feeling of fullness in the abdomen. At high doses (more than 300 mg per day) nausea is common. This symptom is usually transitory, but it may take several weeks to vanish.

PRECAUTIONS: Recent studies suggest that high blood levels of 5HT (serotonin) might cause problems for the heart muscle and fibrous growths on the aortic valve. This is regarded as what happened to users of fen/phen which also raised serotonin levels. Consequently, individuals who have heart problems, such as coronary artery disease, congestive heart failure, pulmonary hypertension, or cardiomyopathy, shouldn’t take 5-hydroxytryptophan. In case you are using any kind of prescription or over-the-counter medication, talk with your doctor before taking 5-hydroxytryptophan. Most likely severe side effects, such as confusion or anxiety, may occur if you take 5-hydroxytryptophan while taking antidepressants, lithium, buspirone, leva dopa , or cold remedies that incorporate ephedrine or pseudoephedrine. If you’re taking antihistamines, muscle relaxants (e.g., carisoprodol, cyclobenzaprine), or narcotic pain relievers, you would possibly experience excessive drowsiness.