Male sex hormone

Dihydrotestosterone (DHT) (referred to as androstanolone or stanolone when used medically) can also be used in place of testosterone as an androgen. The availability of DHT is limited; it is not available in the United States or Canada, for instance, but it is available in certain European countries, including the United Kingdom , France , Spain , Belgium , Italy , and Luxembourg . [5] DHT is available in formulations including topical gel, buccal or sublingual tablets, and as esters in oil for intramuscular injection. [6] Relative to testosterone, and similarly to many synthetic AAS, DHT has the potential advantages of not being locally potentiated in so-called androgenic tissues that express 5α-reductase (as DHT is already 5α-reduced) and of not being aromatized into an estrogen (it is not a substrate for aromatase).

Neural injections of Bromodeoxyuridine (BrdU) were applied to males of both groups to test for neurogenesis . Analysis showed that testosterone and dihydrotestosterone regulated adult hippocampal neurogenesis (AHN). Adult hippocampal neurogenesis was regulated through the androgen receptor in the wild-type male rats, but not in the TMF male rats. To further test the role of activated androgen receptors on AHN, flutamide , an antiandrogen drug that competes with testosterone and dihydrotestosterone for androgen receptors , and dihydrotestosterone were administered to normal male rats. Dihydrotestosterone increased the number of BrdU cells, while flutamide inhibited these cells.

Alkaline phosphatase, hemoglobin and hematocrit, and creatinine may vary depending on the patient's current sex hormone configuration. Several factors contribute to these differences, bone mass, muscle mass, number of myocytes, presence or lack of menstruation, and erythropoetic effect of testosterone. Many transgender men do not menstruate, and those with male-range testosterone levels will experience an erythropoetic effect. As such an amenorrheic transgender man taking testosterone, registered as female and with hemoglobin/hematocrit in the range between the male and female lower limits of normal, may be considered to have anemia, even though the lab report may not indicate so. Conversely, the lack of menstruation, and presence of exogenous testosterone make it reasonable to use the male-range upper limit of normal for hemoglobin/hematocrit. Using the male-range upper limit of normal for alkaline phosphatase and creatinine may also be appropriate for transgender men due to increased bone and muscle mass, respectively. In these cases the provider should reference the male normal ranges for their lab.[19]

• Enhanced weight loss. There is evidence that DHEA helps promote weight loss in laboratory animals, and perhaps in humans as well, although the results are inconsistent, and it is unclear what the operative mechanism is. It may involve appetite suppression or thermogenesis (fat burning) or both. A curious observation is that, in men who lose weight without DHEA supplementation, the natural levels of this hormone tend to rise. This is not true of women, however - still more evidence of the different ways in which this remarkable hormone is metabolized by the two sexes.

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Male sex hormone

• Enhanced weight loss. There is evidence that DHEA helps promote weight loss in laboratory animals, and perhaps in humans as well, although the results are inconsistent, and it is unclear what the operative mechanism is. It may involve appetite suppression or thermogenesis (fat burning) or both. A curious observation is that, in men who lose weight without DHEA supplementation, the natural levels of this hormone tend to rise. This is not true of women, however - still more evidence of the different ways in which this remarkable hormone is metabolized by the two sexes.