It has been shown that there is a dose-dependent effect of BDNF on the glutamate release. The glutamate release is initially observed at 5 ng/ml BDNF and reaches a plateau at 100 ng/ml (Numakawa et al., 2002).

No studies have been found in the literature measuring both KEs after exposure to the stressors. Interestingly, proton magnetic resonance spectroscopy in adults with childhood lead exposure shows decrease in a composite of glutamate and glutamine in vermis and in parietal white matter of the brain (Cecil et al., 2011).

Quantitative Understanding of the Linkage

Is it known how much change in the first event is needed to impact the second?
Are there known modulators of the response-response relationships?
Are there models or extrapolation approaches that help describe those relationships?