Danny Care will become England's most capped scrum-half when he wins his 78th cap and overtakes World Cup winner Matt Dawson, while Jonathan Joseph replaces Ben Te'o in the centre.

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Rhys Patchell: Wales fly-half one day, U16s coach the next

But the build-up to the game has been dominated by England head coach Jones' criticism of various Welsh players including fly-half Rhys Patchell.

Jones said Patchell's own team-mates will have doubts over his "bottle" for Saturday's meeting, comments which were laughed off by the Wales camp.

Jones also questioned Wales captain Alun Wyn Jones' conduct towards referee Pascal Gauzere in Cardiff, prompting the Welshman to joke he was "ready for a chat with Uncle Eddie".

"I don't know if there's an element of deflection or anything like that," Jones said on Friday.

"But ultimately as players, that kind of stuff goes on outside the tent. We are inside the tent and we need to deal with what goes on inside the white lines."

Where will England v Wales be won and lost?

Wales head coach Warren Gatland has three wins from eight matches at Twickenham since he took over in 2007

Wales centre Jamie Roberts, a guest on the Rugby Union Weekly podcast, believes Saturday's battle at Twickenham will be "like a game of chess".

England have won the last three encounters against Wales, including a last-gasp victory in Cardiff in the 2017 Six Nations, but in the past decade under Warren Gatland, Wales have secured three victories at Twickenham.

"I think the players believe they can win there," said Roberts, who expects the influence of "Test-match players", full-backs Leigh Halfpenny and Mike Brown, to be pivotal.

"We talk about the difference between club players and international players. Brown and Halfpenny are guys who can handle pressure and deliver basic skills repeatedly, time after time, at the highest level," he added.

Wales players in their matchday squad who have beaten England at Twickenham

Coverage: Live radio commentary on BBC Radio 5 live and BBC Radio Ulster. Live text commentary, report and video highlights on the BBC website and app.

After a dramatic late victory against France in Paris last weekend, Ireland return home to Dublin to face an Italy side led by former Irish full-back Conor O'Shea.

Ireland are on a run of eight consecutive victories and the Azzurri have only managed two away wins in 45 attempts since joining the Championship in 2000.

Joe Schmidt has made four changes from their opening win, Leinster back row Jack Conan will make his Six Nations debut in place of British and Irish Lion CJ Stander while Jack McGrath, Devin Toner and Dan Leavy also come into the Irish pack.

20-year-old back Jordan Larmour, who has scored six tries in 14 games since making his Leinster debut, is among the replacements.