Phase II: To determine the anti-tumour activity, as measured by overall response rate (ORR) of CT1 specific medication in combination with chemotherapy in patients with chemotherapy resistant CT1 subtype CRC.

To characterize the safety and tolerability of CT1 specific medication in combination with chemotherapy regimens, as assessed by the incidence and severity of adverse events.

To asses anti-tumour activity of CT1 specific medication in combination with chemotherapy, as measured by duration of response, time to response and progression free survival (phase II only).

To determine the pharmacokinetic profile of CT1 specific medication in combination with chemotherapy, as measured by plasma concentrations.

To explore genetic determinants of response to CT1 specific medication in combination with chemotherapy, as measured by baseline molecular status of potential predictive markers of tumour response.

To explore the potential mechanism of resistance to CT1 specific medication in combination with chemotherapy, as measured by gene alterations/expression profiles (e.g. baseline, relapse) in tumour tissue upon progression.

To provide the overall scientific direction and to drive the progress of the project, steering efforts of the partners for the achievement of the project’s objectives and milestones and ensuring that the work is undertaken with appropriate quality levels.

To set-up a project management structure that ensures an efficient operational management including administrative, financial and legal issues, and appropriate liaison with the European Commission.

To ensure that the project is appropriately managed according to the work plan, supporting the Coordinator in organising and supervising the work.

To provide resources, procedures and tools for ensuring that all results are delivered on time, with an adequate quality level and within cost, including quality control procedures on deliverables and interim and final review of the project achievements from a management perspective.

To enable the appropriate communication and work dynamics to help drive the whole Consortium as a team towards successful completion.

To design a plan that allows for optimal communication within the project and the dissemination of information and knowledge generated by the project to relevant stakeholders and the general community.

To create awareness and understanding of the progress that takes place in the context of MoTriColor among stakeholders.

To undertake extensive dissemination activities according to the communication plan.

To design and produce the communication tools that will be needed to implement the plan.

To devise sustainability models for MoTriColor, which ensure the implementation of the results developed during the project.