Browse our anti-CACNA1S (CACNA1S) Antibodies

On www.antibodies-online.com are 58 Calcium Channel, Voltage-Dependent, L Type, alpha 1S Subunit (CACNA1S) Antibodies from 13 different suppliers available. Additionally we are shipping CACNA1S Proteins (8) and CACNA1S Kits (5) and many more products for this protein. A total of 71 CACNA1S products are currently listed.

More Antibodies against CACNA1S Interaction Partners

Study used structure modeling and MD simulations to predict pathogenic omega-currents in CaV1.1 and CaV1.3 (show CACNA1D Antibodies) Ca(2 (show CA2 Antibodies)+) channels bearing several S4 charge mutations: omega-currents conducted in resting state, but not during voltage-sensing domain activation. Mechanism responsible depends on the number of charges in S4, the position of the mutated S4 charge and countercharges, and the nature of the replacing amino acid.

Study identified by exome sequencing both recessive and dominant CACNA1S mutations as a cause of a congenital myopathy characterized by peculiar morphological hallmarks in a cohort of 11 patients from 7 families.

whole-exome next-generation sequencing was used to identify a mutation in the CACNA1S gene, R900S, which is a rare mutation associated with hypokalemic periodic paralysis; study provides further evidence for the phenotypic variation and pharmacogenomics of hypokalemic periodic paralysis

These results provide new insights into the role of muscle-specific (show EIF3K Antibodies) proteins on the structural arrangement of alpha1S intracellular loops and point to a new conformational effect of the beta1a subunit in supporting skeletal muscle excitation-contraction coupling.

The authors found one and three rare variants of unknown significance in CACNA1S in the Malignant Hyperthermia and Exertional Heat cohorts

Defects in the genes coding for the skeletal muscle ryanodine receptor (show RYR1 Antibodies) and alpha 1 subunit of the dihydropyridine receptor (CACNA1S) have been identified as causative for malignant hyperthermia.

TnT3 regulates expression of Cav1.1 in skeletal muscle, this regulation is impaired in aging.

Immunohistochemistry and western blotting after expression of GPR179 (show GPR179 Antibodies) in HEK293T cells indicate that the CACNA1S antibody used here and in the retinal studies published to date, cross-reacts with GPR179 (show GPR179 Antibodies).

These results provide new insights into the role of muscle-specific (show EIF3K Antibodies) proteins on the structural arrangement of alpha1S intracellular loops and point to a new conformational effect of the beta1a subunit in supporting skeletal muscle excitation-contraction coupling.

Events occurring locally in the skeletal muscle of SOD1 mutant mice contribute to the impairment of CaV1.1 function in ALS muscle independently of innervation status.

Treatment of MSC (show MSC Antibodies) with BMP4 (show BMP4 Antibodies) caused a significant increase in expression of Cav1.2 (show CACNA1C Antibodies), a delay in expression of Cav1.1, and a reduction in the duration of calcium transients when extracellular calcium was removed

CACNA1S Antigen Profile

Antigen Summary

This gene encodes one of the five subunits of the slowly inactivating L-type voltage-dependent calcium channel in skeletal muscle cells. Mutations in this gene have been associated with hypokalemic periodic paralysis, thyrotoxic periodic paralysis and malignant hyperthermia susceptibility.