Protein Summary

Gene DR_1065 from Deinococcus radiodurans encodes the NP_294789 protein that belongs to the DinB clan, DUF664 family (PF04978). SCOP classifies 2ou6 in the all alpha class, DinB/YfiT-like putative metalloenzymes, DinB-like family. Dali top hits for 2ou6 are with 2qnl (Z-scr=14), 2p1a (Z-scr=13) and the YfiT protein 1rxq (Z-scr=13).

2ou6 coordinates a nickel ion using a triad of residues: H76, D168 and H172. However unlike most members of the superfamily that use three histidines this protein has an aspartate replacing the second histidine. The superfamily contains many members that have an aspartate or glutamate at this position and based on this structure we would expect that these are functional homologues rather than inactivated relatives.