MDM2 is a nuclear phosphoprotein that binds and inhibits transactivation by protein p53, as part of an autoregulatory negative feedback loop.
Two transcript variants, L-mdm2 and S-mdm2, differing in the length of the 5'UTR, may be expressed.
L-mdm2 results in low constitutive level of protein, while the transcript S-mdm2 seems be actively translated.
L-mdm2 contains a 5' leader derived from exon 1 and contains two upstream ORFs absent from S-mdm2.
In chimeric constructs containing both the 5......

::Features

Feature Key

uORF

::References

ID

[1]

Authors

Jin X, Turcott E, Englehardt S, Mize GJ, Morris DR

Title

The two upstream open reading frames of oncogene mdm2 have different translational regulatory properties.

Citation

J Biol Chem. 2003 Jul 11;278(28):25716-21. Epub 2003 May 02

Year

2003

ID

[2]

Authors

Brown CY, Mize GJ, Pineda M, George DL, Morris DR

Title

Role of two upstream open reading frames in the translational control of oncogene mdm2