Medical condition that develops as a result of long-duration exposure to microgravity and stellar radiation by organics who have not been augmented to deep space conditions.

Victims suffer a gradual change in cardiovascular, skeletal and endocrine functions as their physiology adapts to a weightless environment, making it more difficult for them to function in normal gravity. In advanced stages the condition is irreversible, and the victim is permanently unable to tolerate the physical stresses associated with gravity or acceleration above 0.25 G. The condition is incurable without nanomodification of skeleton and muscles. Most human derived clades have neogen modifications to avoid these problems, as do many other biont Terragen clades. Somatic personal treatments are typically available for those lacking such a heritage.