I played this last weekend--my first experience with Munchkin. It took not two but three hours. At the end, the other four players were all at level nine and at least two of them were threatening to throw the game to each other just so it would be over.

Granted, it's clever that if you "kick open the door" and don't draw a monster, you get to "loot the room" to get another door card--it gives you a second chance to get a monster, and if you do, you can "look for trouble" next turn. On the other tentacle, it means that if you keep drawing non-monsters for both cards, you pretty much don't get any treasure cards. I think the number of items I got in the course of the game was three or maybe four, and one of those was a gift.

I think maybe two or three of the cards got an actual laugh. "Tumescent" was one of them. People were like "What's reptile dysfunction, Daddy?" "It means your lizard is broken." Good times.

Despite all that, I find myself feeling disinclined to play this again.

Haven't played it yet, but by just looking through the cards, I didn't find it to be too funny, either. The by far best genre still is the fantasy Munchkin, in my opinion. Followed perhaps by Munchkin Bites and Munchkin Impossible.