BUENOS AIRES—Argentine President-elect Mauricio Macri on Monday tapped the regional head of General Motors Co. to lead state-run airline Aerolineas Argentinas, according to people familiar with the plan.

Mr. Macri hasn’t yet announced the decision, but two people familiar with Isela Costantini’s plans confirmed she was offered the job and has accepted it. Ms. Costantini had spent about 17 years at the auto maker to become the president of GM Argentina, Paraguay and Uruguay.