– HbS has a valene in place of glutamic acid in the sixth amino acid residue of

beta globulin molecule

Which of the following statements on lymphoma is not true?

a) A single classification system for Hodgkin’s disease (HD) is almost universally accepted

b) HD more often tends to remain localized to a single group of lymph nodes and spreads by contiguity

c) Several types of non Hodgkin’s lymphoma (NHL) may have a leukemic phase

d) In general follicular (nodular)NHL has worse prognostic compared to diffuse NHL

Hodgkin’s Lymphoma most serious subtype is nodular sclerosis. What type of

cell is needed to diagnose HL?

– Jonny fontaine cells

– Reed-Sternberg cells

– John Wayne cells

Acute myeloid leukemia without maturation would show what myeloblast

markers?

– CD34, CD33, CD15

– CDs and 8-tracks

Acute B-cell lymphoblastic leukemia / lymphoma would show what type of cell markers?

– CD22

– TdT

– Cd10

– CD19

– ALL of the above, except the question…I know, ridiculous!

Typical symptoms of ALL/lymphomas (and AML) include all of the following except

– sudden onset

– anemia

– bleeding

– vomiting

– nerve palsies

– headache

What is seen mostly in mostly in children, where there are chromosomal changes,

, hyperploidy, Philadelphia chromosome*, translocations (9;22)

SIGNIFICANT response to chemo: 90% remission,

75% CURE!!!

– Acute lymphoblastic leukemia

– Chronic LL

Examples of mutations in neoplastic proliferations of WBC for acute

leukemia are all except

– Transcription factor

– Tyrosine kinase

– peroxidase

All acute leukemias suppress normal hematopoesis, e.g., have

anemia and

– Blastomas

– Thrombocytopenia

– decrreased perforin

In the case of ___________,

there is an intimate concurrence with malignant lymphomas

– lymphocytes

– erththrocytes

In the case of __________, the primary

process is marrow and peripheral blood, but can involve any

organ or tissue which receives blood.

– Lymphocytes

– neutrophilic precursors

Kostmann syndrome is genetic, congenital, eg, severe neutropenia.

What does this affect?

– Thio-uracil

– Myelopoiesis

What number is the danger zone for

inadequate production / increased desctruction?

– 500-1000/mm3

– 50-200/mm3

In HIV infection (and autoimmune), you would be likely to see

– leukopenia, after glucocorticoids or cytotoxic drug treatment

– high CD4 count

Another bane for B12 is _______. In what anemia would you see

this deficiency?

– Cobalamin, pernicious anemia

– Thiamine, Barrett’s esophagus

Lack of what causes anemia in B12 deficiency?

– Cobalamin

– Folate

B12 combines with intrinsic factor in the gastric mucosa and is absorbed
– in the cecum
– in the terminal illeum
– in the duodenum

How about folate?
– proximal jejunum (yup, it’s the one at the top!)
– cecum

As for enlarged RBC, megaloblasts are in the bone marrow,
what are in the peripheral blood?
– macro-ovalocytes
– micro-ovalocytes

As for giant WBC, what are seen in the marrow, peripheral blood?
– Blastocysts, lymphophils
– giant metamyelocytes, hypersegmented neutrophilsMegaloblastic anemias (non-hemolytic, MCV > 94, macrocytes in peripheral smear)
are due to impaired DNA synthesis and are
also called
– anemias of B12 and Folate deficiency– none of the above

In HGB-S disease (sickle cell), you may see
autosplenectomy, but what infections would you become
more susceptible to?
– Clostridium– pneumococcus, Hem. influ, salmonella, osteomyelitis

Sickle cell trait (or sicklemia)
describes a condition in which a person has one abnormal allele of the hemoglobinbeta gene (is heterozygous), but does not display the severe symptoms of
sickle cell disease that occur in a person who has two copies of that
allele (is homozygous).

Those who are heterozygous for the sickle cell allele produce both normal and abnormal hemoglobin (the two alleles are codominant with respect to the actual
concentration of hemoglobin in the circulating cells).