In Reply We thank Samadani and Hubbard for their review and comment on our article.1 Traumatic encephalopathy syndrome (TES) is a clinical diagnosis with unknown correlation with the pathologic findings of chronic traumatic encephalopathy (CTE). We proposed working criteria for TES to serve as a clinical starting point while research is ongoing in multiple realms, including in the important area of biomarkers for pathologic changes in the brain consistent with CTE. Our proposed clinical criteria are expected to evolve as research provides further insight into objective measures. Presently, however, a guide is required for a standardized approach to current patients. Criteria for TES may be limited at this time, but they are nevertheless an important contribution to the field. Patients are being seen in offices around the world with a history of repetitive head trauma and neurocognitive concerns, and we believe that a schema to guide clinicians as to how to approach these patients is what they deserve.