Nathan Hines has been ruled out of Scotland's RBS 6 Nations game in Wales after suffering a calf strain and aggravating an ankle injury against France.

Leinster star Hines will be replaced at the Millennium Stadium on Saturday by Edinburgh's Jim Hamilton, who has only recently recovered from a long-term knee problem.

Scotland team doctor James Robson said: "Nathan suffered a calf strain and aggravated an old ankle injury during the match at the weekend. Whilst the injury has settled considerably, it is not at a level adequate for exposure to the rigours of Test match rugby and therefore Nathan is withdrawn from selection."

Scotland team for RBS 6 Nations match against Wales at the Millennium Stadium on Saturday, February 13 (kick-off 2pm):