He is famous for playing comic and villainous characters. He is known for acting alongside comedian Kader Khan in over 100 films. Since the start of his career in 1972, he has often been nominated for the Filmfare Award in the Best Comedian category and has won once, for his performance in David Dhawan's film, 'Raja Babu'. Shakti has been an important part of numerous hit films including 'Aasha', 'Khiladi', 'Aankhen', 'Judwaa' and many more.

He is a regular fixture in Priyadarshan's films like 'Hungama', 'Hulchul', 'Chup Chup Ke' and 'Malamaal Weekly' - the more recent and successful films being 'Bhagam Bhag' and 'No Problem'.

Shakti Kapoor is most famous for the his role he played in 'Raja Babu' as 'Nandu' and in 'Andaaz Apna Apna' as 'Crime Master GOGO'