More from: Syk Kinase

Objectives To look for the safety, tolerability and indicators of efficacy of MOR103, a human monoclonal antibody to granulocyteCmacrophage colony-stimulating factor (GM-CSF), in patients with rheumatoid arthritis (RA). were classified as serious because of hJumpy hospitalisation: paronychia in a placebo subject and pleurisy in a MOR103 0.3?mg/kg subject matter. Both patients fully recovered. In exploratory […]

Plasmacytoid dendritic cells (pDCs) play a central function in innate and adaptive immune responses against viral infections. pDC-induced cytolytic activity of natural killer cells. Taken collectively, these data demonstrate that the direct connection of HIV-1 gp120 with pDCs interferes with TLR9 activation resulting in a decreased ability of pDCs to secrete antiviral and inflammatory factors […]