Animal Models of Diabetic Retinopathy

Animal Models of Diabetic Retinopathy
Olivares, Ana; Althoff, Kristen; Chen, Gloria; Wu, Siqi; Morrisson, Margaux; DeAngelis, Margaret; Haider, Neena
2017-08-24 00:00:00
Purpose of Review Diabetic retinopathy (DR) is one of the models, though dogs develop the most similar morphological most common complications associated with chronic hyper- retinal lesions as those seen in humans, and pigs and zebrafish glycemia seen in patients with diabetes mellitus. While many have similar vasculature and retinal structures to humans. facets of DR are still not fully understood, animal studies have Nonhuman primates can also develop diabetes mellitus spon- contributed significantly to understanding the etiology and taneously or have focal lesions induced to simulate retinal progression of human DR. This review provides a compre- neovascular disease observed in individuals with DR. hensive discussion of the induced and genetic DR models in Summary DR results in vascular changes and dysfunction of the neural, glial, and pancreatic β cells. Currently, no model different species and the advantages and disadvantages of each model. completely recapitulates the full pathophysiology of neuronal and vascular changes that occur at each stage of diabetic ret- inopathy; however, each model recapitulates many of the dis- ease phenotypes. This article is part of the Topical Collection on Microvascular Complications—Retinopathy . . . Keywords Animal models Diabetic retinopathy Diabetes . . . . * Neena Haider
http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.pngCurrent Diabetes ReportsSpringer Journalshttp://www.deepdyve.com/lp/springer-journals/animal-models-of-diabetic-retinopathy-9QM0w2eXmd

Abstract

Purpose of Review Diabetic retinopathy (DR) is one of the models, though dogs develop the most similar morphological most common complications associated with chronic hyper- retinal lesions as those seen in humans, and pigs and zebrafish glycemia seen in patients with diabetes mellitus. While many have similar vasculature and retinal structures to humans. facets of DR are still not fully understood, animal studies have Nonhuman primates can also develop diabetes mellitus spon- contributed significantly to understanding the etiology and taneously or have focal lesions induced to simulate retinal progression of human DR. This review provides a compre- neovascular disease observed in individuals with DR. hensive discussion of the induced and genetic DR models in Summary DR results in vascular changes and dysfunction of the neural, glial, and pancreatic β cells. Currently, no model different species and the advantages and disadvantages of each model. completely recapitulates the full pathophysiology of neuronal and vascular changes that occur at each stage of diabetic ret- inopathy; however, each model recapitulates many of the dis- ease phenotypes. This article is part of the Topical Collection on Microvascular Complications—Retinopathy . . . Keywords Animal models Diabetic retinopathy Diabetes . . . . * Neena Haider