Effects of curcumin derivative, MS65 on IL-6 production and cells viability in histamine-induced HaCaT cells. Cells were seeded for 24 h before inducing with 10 μM of histamine. MS65 was tested in two-fold serial dilution with the highest concentration of 50 μM. Cells were then further incubated for 24 h. All values are the mean ± S.E.M. of three independent experiments. Values of *P < 0.05, **P < 0.01 and ***P < 0.001 were considered significantly different to histamine-induced control group