Diseases which affect the glomerular apparatus is the most common affection
of the kidneys. They may be acute nephritic syndrome, glomerulonephritis,
nephrotic syndrome and renal failure. Most diseases of the glomerulus has
immune basis.

Other
conditions may affect the connective tissue such as amyloidosis of kidney in
which there is increase secretion of abnormal fibrillar proteins or a
reduction in their catabolism. It also has an immune basis.