Integration of Liquid Handler Quality Control Into the HTS Daily Routine

Artel

The MVS enables users to measure the performance of all six of the liquid handlers integrated into the cell::explorer system over the entire volume range of 10 nL to 350 μL and provides data that allows direct comparability of instrument performance.

Previous studies1 have shown that highly accurate and precise liquid handling is critical if the results of HTS experiments are to be reliable. However, liquid handlers are prone to variation and error and need to be verified using a standardized methodology. The need for a standardized verification method becomes increasingly important when multiple liquid handlers are used in the same experiment, or when procedures are transferred between instruments and/or locations.

Studies were conducted to prove the verification process does not interfere with assay results and the performance of the liquid handlers integrated into the screening system was assessed. The MVS enabled the analysis of pre-existing protocols and dramatically reduced the time required for routine quality control processes.

Although often forgotten, sample preparation is the most important factor in achieving reproducibility from even the most advanced chromatographic methods. In this paper, you can learn about some ways that sample preparation can affect the selectivity, sensitivity and reproducibility of an analysis.