In this study, PSMA PET/CT was used to examine men who had measurable PSA readings after radical prostatectomy. Recurrent disease was seen on imaging in 55% of men (74 out of 134) with very low (0.2–0.5 ng/ml) PSA and in 74% (102/138) of men with low (>0.5–1.0 ng/ml) PSA.

Based on these findings it seems reasonable to perform PSMA PET/CT in men with early biochemical recurrence (measurable; PSA) , as it can help direct further treatment decisions. Predictors of a positive scan were PSA, current use of hormone treatment (ADT) and to a lesser extent ISUP grade group (Gleason score).