A Wrinkle in Time is the story of a young girl Meg Murry (Reid) and the search for her scientist father (Pine), who has gone missing after discovering a distant planet. Guided by the three mysterious astral travelers known as Mrs. Whatsit (Witherspoon), Mrs. Who (Kaling), and Mrs. Which (Oprah), Murry, her young brother, and their classmate brave a dangerous journey to a planet that possesses all of the evil in the universe.

After helming acclaimed films such as Selma and the Oscar-winning documentary 13th, DuVernay was hired by Disney to adapt A Wrinkle in Time. With a budget exceeding $100 million, it’s the first live-action film of its size to be directed by an African American woman.