ENZYME entry: EC 3.4.22.15

Accepted Name

Cathepsin L.

Reaction catalysed

Specificity close to that of papain. As compared to cathepsin B, cathepsin L exhibits higher activity toward protein substrates, but has little activity on Z-Arg-Arg-NHMec, and no peptidyl-dipeptidase activity

Comment(s)

A lysosomal enzyme that is readily inhibited by the diazomethane
inhibitor Z-Phe-Phe-CHN(2) or the epoxide inhibitor E-64.