A step by step guide with screenshots of each step can also be found here.

First step:

Go to the TSC download page here. Doing that will cause a download window to pop up on your screen. Clean install or new install, choose the 1st option. (We almost never use the 2nd option to upgrade)

In the dialog box that will appear select the "Save" or "Run from this location" option. It is probably better to SAVE. Enter the location on your computer to save the file, and start the download. If you get a warning that says that the application is unknown, select the Accept/Allow button. This is simply a security warning to make sure you know who you are downloading from. This software does not interfere with the normal operation of your computer. Once the installer starts running, you can leave the default options as they are. Just click Yes to accept the installation path. NOTE: You can close the window displaying the molecule at any time. It will not interrupt processing.

Second step:After you have downloaded the program, navigate to the folder where you saved it. Click or double-click on the file. It will be named installTSC.exe. Follow the prompts and let the program install. You will see a window that asks if you want the program to automatically start when you start Windows. Select your preference.

In the next window, you will be asked to enter your email address. You need to be connected to the internet while completing this step.Note: Always register your nodes with the same email address! This will keep them in the same member account.

When you've done this, the program will download its data, and begin to process. You will see the Agent's window for the first time. Your crunching has begun!

In the upper right corner of the Agents screen, you will see a "Node ID". Take note of this number for the next step.

Step Three:Register and join the Team on the TSC site! Go to this site. In the spaces provided, enter your Node number, your email address that you used in the previous step, your member name and a password. (You might want to use your DSLR member name.)

Next, make sure you join Team Discovery on TSC. In the next screen, you will see an option for joining teams. Follow the prompts to a screen where you can search for a team. Click on the B and find Broadband Reports Team Discovery. You can also do this by going here.

•For viewing/interpreting the statistics, this additional information has been provided by Ken Weilbacher of TSC:

To clear up the 'Coverage' statistics some, all of our candidates are assigned multiple times to different nodes and we take an average of all of the docking times.

The 'Coverage' statistics break down like this:

'0 Runs' - these are candidates that have not been released yet or have been released but have not been run by a client node yet.

'1 Runs' - these are candidates that have been run one time by a client node.

'2 Runs' - same as above but run twice.

'3 Runs' - these have been assigned 3 or more times.

The 'Top Drug Candidates' page shows you the rank and name of the top candidates returned; the date, time and node which sent them in; and also the docking energy and average docking time returned from this node and a thumbnail picture of the structure of the candidate.

We run validation routines on all results and some of those candidates returned with extremely low docking energies that would place them in first will not be recognized if these results were corrupted in some way that gave them this low docking energy.

Feedback received on this FAQ entry:

the hyperlink under "here" (d2ol.childhooddiseases.org) in the line:
"•Team statistics on the TSC site are here." does not appear to be functioning on 20110902/1522.

This screen is at the bottom of your display, and can be toggled on and off using the "Stats" button

1) The total number of Candidates your Agent has processed. 2) The number of Candidates your Agent has available to process. The Agent keeps a queue so Candidates can be processed even when your computer is not connected to the Internet.3) The time when processing began on the current Candidate. If the time is "Pending" a task is not currently running. It may take several minutes to begin processing a task when the Agent starts. The time will also be "Pending" if you chose to suspend tasks.4) The time when Conformer results from completed tasks were last uploaded to Sengent. If the time is "Pending" please run your Agent until a task is completed.

This is the HUD image when you've selected a completed Conformer on the left side of your screen. The HUD can also be toggled with a button at the bottom of the Agent.

1) The name of the selected Conformer.2) The total generations calculated by the genetic algorithm.3) The total energy evaluations.4) Additional statistics about the final configuration of the Conformer.5) The final docked energy. Lower scores tend to indicate better matches, including negative numbers.

The compressed installer should be recognized by Stuffit Expander and should automatically be expanded after downloading. If it is not expanded, you can expand it manually using StuffIt Expander 6.0 or later.

If you have any problems launching the installer once it has been expanded, make sure that the compressed installer was expanded using Stuffit Expander. If you continue to have problems, please contact technical support.

First, of course install TSC. Open TSC and right click on the icon in your task bar (near the clock). Select properties. Set your candidate queue to whatever you want. I max mine out. If you have a dialup computer, unselect the online tab. Click ok, and then right click again and select exit.

Now, go to your directory where the d2ol.exe file is. Mine is in C:\program files\CommunityTSC\TSC

In this directory, there is a file called readme.txt.. it might be a good idea to read this. It's kind of hard to understand.

Now edit (with notepad or something like it), the file called launch.xen in the directory mentioned above. Go to to the line that says this:

Now, you want to change your shortcut. The way I'll describe this works for me... I'm on XP. Click on start, then programs, then find the TSC client. RIGHT click on it and select properties. You want to change the target. Mine says

"C:\program files\CommunityTSC\TSC\D2OL.exe"

I change that to

"C:\program files\CommunityTSC\TSC\D2OL.exe" controller:cli

Then click ok!

Now open the program from that shortcut and you're in business.

In the console window that opens, type ? and you'll see the commands you can use.

If you're on dialup, type set Online=true when you're ready to upload your candidates and then so that your computers don't dial out and then set Online=false when you're done uploading. Notice the caps in Online and no spaces around the =. Of course if you're always connected, this is unnecessary. On my machine, I don't see what I'm typing in this console window. This is fine. Type list and you can see what your settings currently are. Use set to change those settings.

Now, this dos/cmd window will always be open, so there is also a file mode which runs in the background and you've got no annoying console window showing open all the time.

Here are some quick instructions:

Install TSC, change your queue size and online selection. Leave that launch.xen the way it originally was. Now, go to that shortcut and instead of

"C:\program files\CommunityTSC\TSC\D2OL.exe" controller:cli

use

"C:\program files\CommunityTSC\TSC\D2OL.exe" controller:file

in the target of the filename.

If you want to close the agent, you open a file called control.prp in the directory that d2ol.exe is located. Change the line, Shutdown=false to Shutdown=true, save the file and TSC will shutdown. Magic.

There is another utility that works with this filemode and also will clean up bad candidates. It's called TSC Check

Finally, there is a light version of the java window. To use this, just change your shortcut to use conroller:java

The most important way to conserve resources on your machine is to not open the graphical window of the program. This may be set to open by default when TSC starts. You'll want to right click on the TSC icon, select properties. In a few seconds, the properties page will open up. Make sure "Launch main window on startup" is NOT checked...

In addition, if you open the GUI (the graphical part of the program), you should always close it by hitting the 'X' so all memory that the GUI was using is released. Minimizing will not do this.

Keeping the client GUI window open, can result in the usage of large amounts of RAM, upwards of 60mb. To maximize the performance you should set all the graphics to low using the slider

... and turn off all the movement by moving the little joystick to the middle.