When females heterozygous for the PWS-ICdel mutation are bred with wildtype males, the resulting offspring are viable and fertile as adults. In contrast, paternal transmission of the PWS-ICdel mutation results in neonatal lethality between 1-7 days of age (failure to [...]

A variety of plasmids are available in which either necdin or Magel2 cDNA is cloned into vectors for expression in yeast, bacteria, or mammalian cells. Contact RachelWevrick@ualberta.ca for information.