Fung TT et al. – The authors derived a dietary pattern that correlated with C–peptide concentrations. This pattern was associated with an increase in colon cancer, especially among women who were overweight or sedentary.

Methods

Major food contributors to fasting C–peptide concentrations were identified with stepwise linear regression in a subsample (n=833) of women from a large cohort.

The authors then summed the consumption frequency of the major food contributors to form a C–peptide dietary pattern for the entire cohort (n=66,714).

Risk for CRC was computed using Cox proportional hazard model with the C–peptide dietary pattern score as the predictor.

Results

In up to 20years of follow–up, the authors ascertained 985 cases of CRC and 758 colon cancer.