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Ultrasound is a unique technology for localizing energy deep into the brain through the skull. The mechanical energy deposited in the focal region, typically a few mm wide, can be utilized to induce thermal or mechanical effects to tissues. Incorporation of microbubbles to the circulation allows to focus the acoustic energy down to cellular level providing the ability to selectively activate the cell’s mechanoreceptors, disrupt cellular and vascular membranes, and induce cell death.

Within this context, the research of our lab is focused on understanding the biological effects of ultrasound and of acoustically induced microbubble oscillations (acoustic cavitation) and use them to study complex biological systems, such as the neurovascular network and the tumor microenvironment, with the goal of developing novel therapies for the treatment of cancer and central nervous system diseases and disorders.