Background/Purpose: In SSc patients, low 25-hydroxyvitamin D (25(OH)D) serum concentrations have been shown [1].Primary aim of the study was to evaluate possible correlations between 25(OH)D serum levels and multiple clinical parameters, in patients with systemic sclerosis (SSc). Secondary aim was the evaluation of the effectiveness of standard vitamin D replacement therapy.

Methods: 154 SSc patients were recruited in all seasons of the year. 25(OH)D serum concentrations were evaluated using LIAISON 25-OH system (Diasorin, Italy). In addition, MedsgerÕs disease severity scale (DSS), nailfold video capillaroscopy (NVC) and all examinations covered by the international guidelines were evaluated [2]. Treatments assumption, including oral colecalciferol, was considered. Non-parametric tests were used for statistical analysis.