Words similar to allelotyping

Example sentences for:
allelotyping

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Amplification and expression of cyclin D1, p53 mutation and deletions of 3p, 5q, and 9p21 are suggested to be influenced by the degree of tobacco exposure [ 4 6 8 ] . The largest effort on this topic has been reported by Koch and colleagues, who found significantly higher rates of p53 mutation and loss of heterozygosity at 3p, 4q, and 11q as part of allelotyping analysis of 10 individual loci [ 4 ] . No studies have utilized true genome-wide evaluative measures to analyze the impact of carcinogen exposure on the accumulated chromosomal abnormalities in HNSCC.

These findings are in contrast to allelotyping studies, which show higher rates of abnormalities in patients with significant tobacco/alcohol exposure [ 4 ] . Since tobacco is known to cause single strand breaks, it may be aberrant repair of these changes that is detected by LOH, which are below the threshold of detection by CGH.