Previous smokers (>10 pack-years). Ten pack years are defined as: 20 cigarettes a day for 10 years; 10 cigarettes a day for 20 years; or 40 cigarettes a day for 5 years. Current smokers, with >10 pack year history, can be included under certain conditions.

Vital signs (after 3 minutes resting measured in the supine position) which are within the following ranges:

oral body temperature between 35.0-37.5 °C;

systolic blood pressure, 100-170 mm Hg;

diastolic blood pressure, 50-100 mm Hg;

pulse rate, 50 - 90 beats per minute (bpm).

Patients must weigh a minimum of 50 kg to participate in this study.

Able to provide written informed consent prior to study participation.

Able to communicate well with the investigator and comply with the requirements of the study.

Exclusion Criteria:

Pregnant women or nursing mothers.

Patients with a QTc interval above 0.43 seconds for males and 0.45 seconds for females at the screening visit. If pre-treatment values on Day 1 of the treatment periods exceed 0.45 and 0.47 seconds for males and females respectively the visit may be re-scheduled once.

Patients with a history of prolonged QTc intervals, or a family history of prolonged QT syndrome.

Predominant diagnosis of asthma. (Patients must present without evidence of active asthma.)

Patients who have been hospitalized or had emergency treatment for acute COPD exacerbation in the one month prior to or during screening.

Patients who have had a respiratory tract infection within one month prior to screening.

Patients with concomitant pulmonary disease, including a history of cancer

Other exclusion criteria apply.

Contacts and Locations

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study.
To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below.
For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00129831