Department of Experimental and Clinical Pharmacology, College of Pharmacy,University of Minnesota, 7-153 WDH, 308 Harvard Street SE, Minneapolis, MN 55455, USAThe number of reports of drug interactions is so great as to be overwhelmingto most clinicians. On average over the last decade there were 60 papers per yearcited in PubMed with ‘‘drug interaction’’ in the title, and 1420 pape