Capsaicin is a pungent ingredient in chili red peppers and has been linked to suppression of growth in various cancer cells. However, the underlying mechanism(s) by which capsaicin induces growth arrest and apoptosis of ...

BACKGROUND: Glucose homeostasis is distorted by defects of the PI3K/AKT and AMPK pathways in insulin-sensitive
tissues, allowing the accumulation of glucose in the blood. The purpose of this study was to assess the effe ...

Genome instability is a prerequisite for the development of cancer. It occurs when genome maintenance systems fail to
safeguard the genome’s integrity, whether as a consequence of inherited defects or induced via exposu ...

The essential oil from two Lantana species (Lantana lucida Schauer and Lantana salzmannii Schauer) were evaluated for their chemical composition by GC-MS. Results showed 17 predominant compounds for L. lucida, among whic ...

An increasing number of studies suggest an important role of host immunity as a barrier to tumor formation and progression. Complex mechanisms and multiple pathways are involved in evading innate and adaptive immune resp ...

Reproductive and endocrine disruption is commonly reported in aquatic species exposed to complex contaminant mixtures. We previously reported that Atlantic killifish (Fundulus heteroclitus) from the chronically contamina ...

Perfluorooctanesulphonicacid (PFOS) is an organic contaminant that is ubiquitous in the environment, wildlife, and humans. Few studies have assessed the effects of chronic PFOS exposure on central nervous system function ...

Analytical methods capable of trace measurement of semi-volatile organic
compounds (SOCs) are necessary to assess the exposure of tadpoles to contaminants as a
result of long-range and regional atmospheric transport an ...

Remote national parks of the western U.S. and Alaska are not immune to contaminants of emerging
concern. Semivolatile organic compounds (SOCs) such as pesticides and PCBs can selectively deposit from
the atmosphere at ...

A central goal of green chemistry is to avoid hazard in the design of new chemicals. This objective is best achieved when information about a chemical's potential hazardous effects is obtained as early in the design proc ...

The immune toxicity of the ubiquitous environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), commonly referred to as dioxin, has been studied for over 35 years but only recently has the profound immune sup ...

Cell death is a process of dying within biological cells that are ceasing to function. This process is essential in regulating
organism development, tissue homeostasis, and to eliminate cells in the body that are irrepa ...

Cell death is a process of dying within biological cells that are ceasing to function. This process is essential in regulating
organism development, tissue homeostasis, and to eliminate cells in the body that are irrepa ...

More needs to be done by the private sector to optimize the drug discovery and development pipeline. In addition, significant efforts should also be focused on the understanding of mechanism of diseases, on the character ...

As a persistent organic contaminant, perfluorooctanesulphonic acid (PFOS) has been widely detected in the environment, wildlife, and humans. The present study revealed that zebrafish embryos exposed to 16 µM PFOS during ...

Although it is known that polycyclic aromatic hydrocarbons (PAHs) can be found in smoked meats, little is known about their prevalence in Native American smoked fish. In this work, the effect of traditional Native Americ ...

An emerging area in environmental toxicology is the role that chemicals and chemical mixtures have on the cells of the human immune system. This is an important area of research that has been most widely pursued in relat ...