A number of the artefacts found inside the church are originals from the first church. One of these is an important sixteenth-century painting of the Augustinian Nicholas of Tolentino depicted by the famous artist Mattia Preti. This is found in the chapel of the same saint.

In the first chapel to the left, there is a painting of the AugustinianJohn of Sahagun who was born in Spain in 1430. It is from the school of Preti and some of its figures can be found depicted on the ceiling of St John's Co-Cathedral in Valletta. Beneath it there is a small painting of Our Lady of Grace, undated and unsigned, also from the first church.

The church is renowned for the statue of St. Rita. Her feast is celebrated in May with a procession with her statue in the streets of Valletta.