Our aim is to obtain a mechanistic insight into the birth of hematopoietic stem and progenitor cells in embryonic development and determine the contribution of these cells to the emerging hematopoietic and immune systems of the embryo. Read more

Our aim is to obtain a mechanistic insight into the birth of hematopoietic stem and progenitor cells in embryonic development and determine the contribution of these cells to the emerging hematopoietic and immune systems of the embryo. Read more

Our laboratory studies the mechanisms regulating normal blood stem and progenitor cell differentiation and how these are perturbed in blood cancers such as Acute Myeloid Leukaemia (AML) and Myelodysplastic Syndromes (MDS). Read more

Our laboratory studies the mechanisms regulating normal blood stem and progenitor cell differentiation and how these are perturbed in blood cancers such as Acute Myeloid Leukaemia (AML) and Myelodysplastic Syndromes (MDS). Read more

This started with the investigation of T cell recognition of peptides derived from intracellular proteins of Influenza (Townsend et al 1986), that evolved into the development of a live attenuated, single cycle Influenza vaccine, based on these principles (Powell et al, 2012; Baz et al, 2015, Holzer 2018). Read more

This started with the investigation of T cell recognition of peptides derived from intracellular proteins of Influenza (Townsend et al 1986), that evolved into the development of a live attenuated, single cycle Influenza vaccine, based on these principles (Powell et al, 2012; Baz et al, 2015, Holzer 2018). Read more

In Sahakyan Group, we strive to make computational biology maximally independent from empirical experimental data, by basing our models and predictions on genomic sequences and core biological mechanisms. Read more

In Sahakyan Group, we strive to make computational biology maximally independent from empirical experimental data, by basing our models and predictions on genomic sequences and core biological mechanisms. Read more

My group focuses on the biology of megakaryocyte cells - large, rare cells found in the bone marrow that release blood platelets into the circulation and also produce many growth factors and other proteins that regulate blood cell development and the bone marrow microenvironment. Read more

My group focuses on the biology of megakaryocyte cells - large, rare cells found in the bone marrow that release blood platelets into the circulation and also produce many growth factors and other proteins that regulate blood cell development and the bone marrow microenvironment. Read more

Over the past decade, numerous efforts have been deployed to reproduce the development of HSCs in vitro from pluripotent stem cells as it happens in the embryo, for mechanistic and therapeutic purposes. Read more

Over the past decade, numerous efforts have been deployed to reproduce the development of HSCs in vitro from pluripotent stem cells as it happens in the embryo, for mechanistic and therapeutic purposes. Read more