The aim of the journal is to critically (without ideological bias) evaluate the current achievements in every field of neuropsychiatry, particularly illness course and treatment effectiveness. All papers in this journal are peer-reviewed. No person is permitted to take any role in the review of a paper in which they have an interest, e.g., fees or grants from, employment by, consultancy for, shared ownership in, any close relationship with, an organisation whose interests, financial or otherwise, may be affected by the publication of the paper.

This book wants to recapitulate the cellular and molecular mechanism underlying the adaptative and evolutionary nature of cancer and to discuss how we might take advantage from considering cancer an adaptative and evolutionary disease to design new strategies for cancer therapy and prevention.

Although psychosis constitutes a terrible disruption in the life of an adolescent, the long term effects can be considerably ameliorated by rapid diagnosis and decisive therapeutic action. The SPI-CY will prove to be a vital piece of equipment in helping us revolutionise the care of young people with early-onset psychosis.

The Schizophrenia Proneness Instrument, Child and Youth version (SPI-CY) has its origin in the basic symptom concept first described by Gerd Huber. Basic Symptoms are subtle, subclinical self-experienced disturbances in drive, stress tolerance, affect, thinking, speech, perception and motor action, which are phenomenologically clearly distinct from (attenuated) psychotic symptoms. They can be present before the first psychotic episode, between and after psychotic episodes, even during psychotic episodes themselves. They are thought to be the most immediate psychological expression of the neurobiological disturbance underlying the development of psychosis – thus the term ‘basic’.