Basic and Clinical Neuroscience Journalمجله علوم اعصاب پایه و بالینیBCNMedical Scienceshttp://bcn.iums.ac.ir137journal1372008-126X2228-744210.32598/bcnenjalali139161gregorian20129135online1fulltextenProtective Effect of L-Arginine against Oxidative Damage as a Possible Mechanism of its Bene.cial Properties on Spatial Learning in Ovariectomized RatsCellular and molecular NeuroscienceCellular and molecular NeuroscienceOriginalOriginal<p><strong>Introduction:</strong> The role of ovarian hormones and nitric oxide (NO) on oxidative damage in brain tissues as well as learning and memory has been widely investigated.</p><p>The present study was carried out to evaluate the effect of the precursor of NO, L-Arginine on learning and brain damage due to oxidative stress in ovariectomized (OVX) rats.</p><p><strong>Methods:</strong> Thirty -two rats were divided into four groups: 1) Sham, 2) OVX, 3) Sham-L-Arginine (Sham-LA) and 4) OVX-L-Arginine(OVX-LA). The animals of sham- LA and OVX-LA were treated with 500 mg/kg of L-Arginine. The animals in Sham and OVX groups received 1 ml/kg saline. The animals were tested in Morris water maze and .nally, the brains were removed and MDA and total thiol concentrations were measured.</p><p><strong>Results:</strong> The escape latency and swimming path in OVX group were signi.cantly higher than in Sham group (p<0.01). The animals in OVX-LA group had signi.cantly lower swimming path length and escape latency compared to OVX group (p<0.01) while, there was no signi.cant difference between Sham- LA and Sham groups. In OVX-LA group, the brain tissues total thiol concentration was signi.cantly higher, and MDA concentration was lower than of OVX group (p<0.001).There was no signi.cant difference between Sham-LA and Sham groups. </p><p><strong>Discussion:</strong> It seems that the bene.cial properties of L-Arginine on spatial learning of ovariectomized rats are in part due to its protective capacity against oxidative damage.</p>Learning, Ovariectomy, L-Arginine, Morris Water Maze, Rat, Oxidative Stress.3644http://bcn.iums.ac.ir/browse.php?a_code=A-10-1-129&slc_lang=en&sid=1MahmoudHosseini13700319475328460022531370031947532846002253Yes
MasoumePourganji13700319475328460022541370031947532846002254NoFatimehKhodabandehloo13700319475328460022551370031947532846002255NoMohammadSoukhtanloo13700319475328460022561370031947532846002256NoHodaZabihi13700319475328460022571370031947532846002257No