While Midtown South remains a mecca for media and digitally driven companies, some firms are looking elsewhere — perhaps due to asking rents that have soared into the $80s per square foot and overtaken pricing prime areas in Midtown.

The biggest possible exit from Midtown South would be Spotify relocating from Sixth Avenue at 18th Street to Four World Trade Center, where it’s negotiating 400,000 square feet.

Now, Take-Two Interactive Software is relocating its national headquarters from 622 Broadway to the Durst Organization’s 1133 Sixth Ave., where it just signed a 15-year lease for 61,383 square feet. The asking rent was $80 per square foot.

The deal for the entire second and third floors comes with lollipops. Durst Organization President Jody Durst said Take-Two will enjoy “a unique work environment for their employees.”