Charlie Bryant worked within the restaurant and was soon joined by his brother Arthur Bryant. In 1940 when Perry died, Charlie took over the restaurant. Arthur in turn was to take it over.

Interior of the location at 18th and Brooklyn

The restaurant was located for many years at 18th and Euclid Streets in the inner city neighborhood of 18th and Vine. Bryant moved the business to its present location, 1727 Brooklyn, in 1958. In the 1950s and through the early 1970s, it was visited by fans and players visiting Municipal Stadium, home to the Kansas City Athletics (1955–67), Kansas City Chiefs (1963–71) and Kansas City Royals (1969–72). The stadium was located five blocks south of the restaurant before being razed in 1976.

The restaurant has never strayed far from its unpretentious decor with formica tables, fluorescent lighting, and jugs of sauce placed in the windows. While Arthur Bryant's is known for the full range of barbecue dishes, its acknowledged specialty is burnt ends, the flavorful end pieces of smoked beef brisket; burnt end sandwiches are served open-faced at the restaurant. Its sauce (which is characterized by tastes of vinegar and paprika rather than sweetness) is sold on the Internet and by mail, and at various locations including Kansas City International Airport.

Arthur Bryant died in 1982, and the restaurant is now owned by Katherine Bryant, Samuel Bryant, etc who expanded the restaurant to the Kansas Speedway and Ameristar Casino. The location at Ameristar Casino closed in January 2014, after the restaurant was unable to work out a new lease deal with the casino.[2]