In this study, a high resolution 3D-MRSI protocol at 3
Tesla was used in female breast cancer patients before and after treatment
(chemotherapy). In total, three patients were scheduled for two or three
measurements. In two patients Cho was detectable before treatment, but, after
treatment, the Cho resonance was no longer detectable. In one patient Cho was
detectable in all three measurements with variable SNR. Approaches for absolute
quantification are necessary for future applications, which would allow more
reliable monitoring of the response to chemotherapy in breast cancer.