Delta-isomerase 2 (HSD3B2) which catalyzes the conversion of Dehydroepiandrosterone (DHEA) to androstenedione, a critical step in producing DHT from adrenal androgens, is also overexpressed at high levels [201]. Taken together, these data suggest a mechanism for how MCRPCa cells can continue to upregulate genes that require AR transactivation. The most obvious argument against this model is that t