Two Breast-Cancer Drugs Pass Milestone

Sara Murray and Ron Winslow discuss a pair of breast-cancer drugs reaching a milestone, and John Jurgensen looks at Beyonce's new album.

This transcript has been automatically generated and may not be 100% accurate.

... I ... yet experimental breast cancer does have a major milestone when ... he got a path for new medicines to come to the market ... welcomes your Friday lunch break and Sarah Mary ... easyJet are helping to boost the credibility of across the second one ... final chance on the market faster ... how can science deputy beer chief Ron Winslow and fewer thought Iran ... was so what ... about the findings from these drugs that have recently researchers encouraging this could be the key to getting drugs to market ... well this is a mobile trial that is ... being cats removed these drugs in an interface to a midstage trial ... when ... they tested this these drugs in patients ... with particular markers ... that would make them unlikely to respond to drugs and they got very significant responses ... you know ... you ... can lead to foreign part of what type of breast cancer ... for once restructure ... the end of ... that the results were ... strong enough that they feel that in the ... next phase trial will be able to ... um have a successful trial in ... a much smaller number of patients than would be the case in the conventional study and was a concern is that right now when you get into these late stage trials for the cancer does is a really high failure rate so it is the case that about ... I'm currently in a conventional trial ... of thirty two only thirty to forty percent succeed ... the late stage with the Drug plugin companies awarded huge investment in them ... hundreds sometimes thousands of patients ... um haven't ... gone through trial ... and so ... if we could get away you can find a way to reduce the numbers the patience necessary to be more specific about ... it and record about treatments that protesting ... we might be able to come up with more success and get things moving faster now hoping that ... these new drugs can do that you can better tailor the kind of drunk year offering to the kind of a shift that could melt tell you this is the big theme in in cancer a ... large right now ... on this particular drugs one of them ... from AbbVie ... Our proved effective in a type of breast cancer called triple negative breast cancer ... which is ... like it sounds mockery from reaching the cancer ... the other one from Puma Biotechnology was ... a promising new in ... her two positive ... the cancer breast cancer ... and um if they ... if the late stage trials to select vocations with those exact type of cancers in a test drive ... of the hope is ... that ... I'm rather than take all kinds of breast cancer patients who ... who ... who may not have those particular ... characteristics ... on that ... you have a much more ... well we don't ... know how far we now he is feeling good progress is is he living in the right direction but ... how far we still from being able to get these drugs to market faster what what other hurdles ... well there are some cases were this'll recapping the FDA has a breakthrough designation an accelerated approvals policies ... this particular were ... that these particular goods are probably you know still several years away ... um but were mixed with a couple years away ... there needs to be more ... work done to establish that the response ... that they got in this trial ... which was ... sort of ... look that this is how for how the tumors responded to six months of chemotherapy before tumors who've been removed from surgery by surgery ... whether that response actually predicts a much more durable and cool response is what ... the FDA will want to know ... before eroded ... get the full blown approval to the drugs I really interesting career on things for being here thanks lots are ... full of more immediate family comeback in the second ... Tce ... I see music is more than just ... when I hear ... in an honest ... to something ... immediately see a visual ... detail and thus the ... series and just in time ... to see in the mind and emotions ... yes if all of the pride in the sense of pride and I really think her self titled ... album on iTunes overnight ... completely Media's preached on John jure ... security detail ... I got ... so if this ... turns the model in its hand there's no single there's no higher the preceding any Energy's wind that was put out is this the new feature the music industry will feature the music industry is coming up with ways to surprise ... to do some has not been done ... under a thousand times ... of it so that seems to be the arms race in the music business fanatical models for leasing and moaning ... and don't s early seem that that was cemented into a hundred times so this this and this study is not a surly new that will surprise album ... David Bowie when he releases album recently ... after a long hiatus was it was a pretty big stocks a lot of people ... but ... our purpose our skilled fiance works with dozens of producers and many many view music music video directors Assisi for this project ... it's really really difficult to keep these projects secret so that's a huge achievement and so ... on any of the wench I mean you would take a look at what she set about it ... she said in one early spring musical and got an important that I feel I can able to speak directly to my face ... but when she was early this afternoon she announced ... at the new album on Instagram previously chance for Super Bowl appearance on tumbler ... how hard is the social media component events for someone like that skied everything now know you don't want to be seen as tied to the old ways of the music business which is ... no you do you pee aren't your traditional PR lease which includes interviews with people like myself ... much to my chagrin few ... bypassing the media now ... going for the defense and that's that's true that that that is important um and I think what's also cool is that she's not just ... dropping an album and the fact that they're seventeen music videos hear ... more music videos an actual songs and I think that part of it ... really the sky to push for the idea when I'll ... just write what I like the asset does but in the piano Allen aims to continue on with many music is though is when look like yet mean I think if people are still not sure if this is complete successful people are still analyzing what this packages ... but the fact that she's trying to integrate it all together you comes in a package together it's it's meant to be seen as one unit not just a drop down the GSEs move by themselves ... and she is emphasizing the fact that she is not just the musical received its official artist too ... um I think that's also really really important ... um going for it you know it's also easy to that within the statement that comes along with the new album ... to make it very clear that there will be a CD its release in time for the holidays where they can be no given the more picked up on it to get by and so what you have done exactly so that that is hugely important still in the business but this is all about the rollout now I mean if you look at arcade fire for to the same thing ... I think it these days you can either go with lots of little teases to prepare people for now we do the Beats element of surprise ... it also seemed like she helped generate buzz for this having heard ... I haven't real ID on in the al with their WeChat preliminary The about the review of Cyprus for the baby ... and that Jay Z has done the same thing to watch on his last release so ... you know the fact that he's on the record as well so the fact and family therapy or completely obsessed with this this whole family unit ... aam released assuming but you know that the number of people involved in this this project is is pretty pretty impressive ... many more to offer year and a half according to their ... relief selling Apple right I think it'll mean with with artists like this the boys were killed music so that's not a surprise but to be overcome with altogether and I choose to do if you Apple's also smart because that's the country that ... prizes secrecy ... and is very quiet about things so they can speak and work with MTC ... I can tell that they can just be of great scenery PTT everything is fine if you have had ... some kind of business mind and be willing to push beyond love about where this industry is that way if you really wanna be in France Kylee PRA dreading going back that idea of trying something new strategy has been on for example Jay Z with this app release that was it ... was loaded rocky on the rollout but it was a smart idea about how to release the album so ... I was trying to think of what they can do besides just ... plop down the music is the time for some years I they're suddenly said that though I was a great Ballmer least is the aunt on your way is well that this is this is that pushing things well be I think even in a distinct promises learning can thanks for being here ... read the year ended neither the optical what happens when thousand Star Tribune each other for cereal in the comeback ... it's ... I ... the ... or Ollie you stand in the euro news that the optical light appears that if he wants for you you ... Jennifer wanted her has been deemed jets that she joins us now with all the de tails I Jennifer and somehow it even gets started ... well it started three at the GOP ten years ago the firm mine has been ... a ... lack of fitting socks and the laundry ... so I think it's her to fall into this wonderful year the verge of ... a match that looked to be a little bit careful with the county of peace deal one of the very end I that that Friday somewhat picky derating overview I ... guess I didn't see this is not the time to air all of your credence as ... it's really a chance to step out of the fifty D day and take a bigger ... picture view of merit ... even your friends have now caught on to the fact that way ... well it actually after this out when to print I've got no money nothing in my not important enough when they are not revealing make ... it certain there is a joke with friends at the way of ... hearing those tiny grievances in a non threatening joke like Whac he said the EU at the plant when your friends mean you always around thirty minutes late gas fell from the mind of twenty years so we had a good solid relationship I'd she was routinely Lee and so the fact that over dinner ... and a fantastic completely as her friends ... I also tested to the the thirty minute free kick the can or can she laughed and it ended ... this is not the kind of thing you wanna try with someone you don't have that kind of strong relationship with glee I think the best advice is to know your audience and know your boundaries Politico through your husband how he prevent this from basically sleeping score all year in Adelaide as though you did this so I'm entering town guests and this is ... this is not a replacement of the day to day conversations were the things couple to come up with a this is more freely it up it's mostly positive it's the way of ... of setting goals is the couple and looking at the big picture it's not hearing those little tiny prevent the now half an hour in one room year year has been actually the Centerview your mother ... and mother in law and the date the hell ... I did know that was happening and then prefer to lay it IAC answer a white antelope ... and she beat that and at the bottom with the year the acne for him for that with new pulp production down ... from peak ... and she loved it and I were him for the mini file protection this year on and that she's busy at work and it's only eight its parts ... I mean look thank you very much for during the hearing that really interesting ... will was here where people say doing that ... well the holiday party season is in full swing and chances are there's a little less one corporate money party on your calendar as highly as Susan Sullivan ... small business expert she's here today with some holiday party Deans and ... I didn't die hard ... anyhow one day ... in and say let's ... Nenad your company is having holiday party a lot of companies entering recently ... have Apple are having the city should probably show up at spelling or one you know you've really shed interesting research is that most people like sort of wrong when the thing about the holiday party ... and it's tempting to say I did something else going on and blowing up ... doll low enough to let the money in your immediate family have passed away ... or you're in the emergency room with an appendectomy ... don't ... blow it up it's it's part of work at the letter a couple either cues and don'ts to get through these corporate party okay well the first thing if ... you are going to go to the party you wanna arrived early I know they always say actually lay in this case you wanna write early primarily because ... this is that the time that you can talk to people ... you're not busy already Koreans not packed so arrive early Doolittle networking and getting to have some quality time with people ... Yuasa one acknowledge or hosts ... so even if it's not in someone's home ... if your boss is their whoever's been responsible for planning a party ... to look to them and say thank you nice and that ... that's true when you arrive and when you leave ... and he said it would make sure you get that networking Nash a barrel on ICE to go to a company parties and we go to the scene people that we got to have read the op is ... and that's your sipping wine with all my ... Trish anytime you wanna hang around your house right at the party ... know you really are to stretch yourself and go speak to ... other people in the room people from other departments ... this of the time or you can go to your boss's boss's boss and say hello he was he just don't wanna make the mistake of monopolize thing anyone and don't push too hard on business that is the social event and let ... that sway make sure you're taking out an outfit that isn't over yet but still look back and mustard phablets ok have a little bleeding ... but you certainly don't wanna go full out that's that's the thing in your closet say that prayer social events this is the work of that ... so you wanna think about it in those terms which you feel comfortable walking into the office and then found it now it is plain that it is likely she will have to tell people this ... let let's talk about alcohol consumption of the outfits that already yes ... God to limit your alcohol consumption one may be teetering ... know what happens when you start drinking even if any that everybody else around you is drinking ... that's no excuse ... that it limits your judgments that we start doing it in painter let's get a little is ... and who knows you can end up on YouTube you now and that's just inquiry or disaster ... they don't wanna make that mistake I I like my on a Friday rose one glass of wine one glass of water a very smart that's a good rule and really now it's really a good thing to keep in mind and do everything in moderation so ... you know off color jokes even though it seems like a social event ... don't give a little flirty with the cute guys you know ... those are the things can lead to sexual discrimination effects on traffic lanes ... so just be Beery careful or I'll get tips for surviving the opposite party meeting thanks for being here thinking here ... luxury developers are pouring money into homes that pushed the design on a little bit WSJ's Mansion team takes you inside ... ay ay mm mm ... I ... still the multimillion dollar homes on staff was no fire on the horizon ... is a risky venture ... now the states are even higher as developers are breaking from traditional home design ... and construct in contemporary glass and steel houses with old merchants ... in Miami approved workers is putting the finishing touches on tennis days modernist home ... seven bedrooms seven a half bath home is concrete floors covered with a resin finish ... in the living area that rises twenty four speech at the ceiling ... with a wall of glass showcases the Polanski ... the doors in this voluminous principal feet tall and twenty bike twenty foot concrete wall was imbedded within the team to the relief of a massive oak tree ... Mr. day is listing the home for nine point eight million dollars ... in Aspen Colorado ... many buyers to enjoy more traditional approach ... but even those homes are taking cues from modern architecture ... developer Bob boding describes the spec home as the Brazilian modern in the mountains ... was later tones minimal Lions inexpensive glass panels ... the roughly eighty one hundred square foot home is listed at thirteen point nine million dollars ... pushing the envelope with modern design doesn't come without its risks ... if the home is to teach ... the kid a leading fires in winter on the market ... costing the developer tens of thousands of dollars in carrying costs for mom ... but thanks to an infusion of buyers the more adventurous tastes ... the high concept house may actually be the safer bet than some of the country's top markets ... selling antiforeign your Friday after the lunch break and Sarah Mary ... err err err I ... I