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John Stamos Boards Fox's 'Scream Queens'

He'll reunite with Ryan Murphy following previous collaborations including 'The New Normal' and 'Glee.'

John Stamos is returning to Fox.

The Grandfathered star is reteaming with Ryan Murphy and has boarded Fox horror-comedy Scream Queens as a series regular for season two.

Season two of the series, from Murphy and Brad Falchuk, is set in a hospital where some of the most fascinating and bizarre medical cases are under observation. Stamos, who previously played a doctor on NBC's ER, will play Dr. Brock Holt, the hospital’s brilliant but secretive head surgeon.

The casting brings Stamos back to Fox a month after the network canceled comedy Grandfathered after one season. The actor, meanwhile, will continue to pop in and out of Netflix's Fuller House, which has already been renewed for season two.