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I wonder whether to use grammar “gamma” or grammar “gc”.I still do not understand the difference between them. As suggested by the Package ‘GenABEL’ (February 19, 2015) , I read the papers by Amin N, van Duijn CM, Aulchenko YS. PLoS ONE (for GRAMMAR-GC) and Svischeva G, Axenovich TI, Belonogova NM, van Duijn CM, Aulchenko YS. Nature Genetics. (for GRAMMAR-GAMMA). However the difference when to use either method was not explained.I tried both methods on my population,by increasing the values of h2 at each run (starting from h2 = 0.13).These are my conclusions. 1. The three most significant markers at h2=.13 stay in the list of the top 10 for Pc1df till h2=.9999.2. The value of Pc1df of each marker is the same using –gamma or –gc, at either h2.3. In grammar-gc P1df is always less significant than Pc1df (WHY?)4. In grammar-gamma P1df is always more significant than Pc1df (WHY?)5. The effect of the minor allele (B effect) is lower in grammar-gc than in grammar-gamma.6. The effect of the minor allele (B effect) in grammar-gc decreases as far as the value of h2 increases (WHY?)7. The effect of the minor allele (B effect) in grammar-gamma increases as far as the value of h2 increases (WHY?)Could anybody tell me if such results should regularly be expected or if I did anything wrong?