On September 27, 2008, the Florida Gators (10-1) lost 31 – 30 to Eli Manning’s college team Ole Miss (7-4), but if they had not lost that game they would probably be #1 or #2 in the nation and they would definitely have an 11-0 record rather than 10-1.
Update: my bad, Florida is currently ranked #2 in the AP polls as of Sunday 11/23.

I mean Tim Tebow passed for 319 yards and one touchdown, and he rushed for another 2 touchdowns. Apparently the offense took the first and third quarters off, and the defense basically took the whole game off.