This chapter explores the dynamics of cross-cultural communication, primarily among the kingdoms and empires of Western and South Asia after Alexander the Great. This period witnessed the rise, conflict, coexistence and fall of a succession of cross-continental empires, including that of the Seleucids (312-64 BCE) and Mauryas (321-185), as well as powerful regional powers with larger ambitions such as the Ptolemies of Egypt, the Diodotids and Euthymids of Bactria (ca. 25o–ca. 145), Sungas (185-73), and a variety of Indo-Greek kingdoms (ca. 185 BCE–ca. 10 CE). Several new Iranian-speaking elites, including the Parni, Saka, and Yuezhi, descended from the Central Asian steppes and eventually formed the Arsacid, Indo-Scythian, and Kusana empires, respectively. These Macedonian, Indian, and Iranian powers engendered an intensive period of diplomatic interaction and cultural exchange. While this chapter focuses first on peer-polity diplomatic communication, it also explores the relationship between direct, intentional communicative acts and the wider contexts of cross-cultural interaction in which they took place and to which they often contributed.