End Stage Renal Disease (ESRD)

End Stage Renal Disease (ESRD)

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What is renal failure?

Renal failure refers to temporary or permanent damage to the kidneys that results in loss of normal kidney function. There are two different types of renal failure--acute and chronic. Acute renal failure has an abrupt onset and is potentially reversible. Chronic renal failure progresses slowly over at least three months and can lead to permanent renal failure. The causes, symptoms, treatments, and outcomes of acute and chronic are different.

Conditions that may lead to acute or chronic renal failure may include, but are not limited to, the following:

Acute renal failure

Chronic renal failure

Myocardial infarction. A heart attack may occasionally lead to temporary kidney failure.

Ingestion of certain medications that may cause toxicity to the kidneys.

Nephrotic syndrome. A condition that has several different causes. Nephrotic syndrome is characterized by protein in the urine, low protein in the blood, high cholesterol levels, and tissue swelling.

Glomerulonephritis. A type of kidney disease that involves glomeruli. During glomerulonephritis, the glomeruli become inflamed and impair the kidney's ability to filter urine. Glomerulonephritis may lead to chronic renal failure in some individuals.

Polycystic kidney disease. A genetic disorder characterized by the growth of numerous cysts filled with fluid in the kidneys.

Any condition that may impair the flow of oxygen and blood to the kidneys such as cardiac arrest.

Cystinosis. An inherited disorder in which the amino acid cystine (a common protein-building compound) accumulates within specific cellular bodies of the kidney, known as lysosomes.

Interstitial nephritis or pyelonephritis. An inflammation to the small internal structures in the kidney.

What is end-stage renal disease (ESRD)?

End-stage renal disease is when the kidneys permanently fail to work.

What are the symptoms of renal failure?

The symptoms for acute and chronic renal failure may be different. The following are the most common symptoms of acute and chronic renal failure. However, each individual may experience symptoms differently. Symptoms may include:

Renal ultrasound (also called sonography). A noninvasive test in which a transducer is passed over the kidney producing sound waves which bounce off the kidney, transmitting a picture of the organ on a video screen. The test is use to determine the size and shape of the kidney, and to detect a mass, kidney stone, cyst, or other obstruction or abnormalities.

Kidney biopsy. This procedure involves the removal of tissue samples (with a needle or during surgery) from the body for examination under a microscope; to determine if cancer or other abnormal cells are present.

Computed tomography scan (also called a CT or CAT scan). A diagnostic imaging procedure that uses a combination of X-rays and computer technology to produce horizontal, or axial, images (often called slices) of the body. A CT scan shows detailed images of any part of the body, including the bones, muscles, fat, and organs. CT scans are more detailed than general X-rays. Contrast CT usually cannot be done when there is kidney failure.

What is the treatment for acute and chronic renal failure?

Specific treatment for renal failure will be determined by your doctor based on:

Close monitoring of important electrolytes such as potassium, sodium, and calcium

Medications (to control blood pressure)

Specific diet requirements

In some cases, patients may develop severe electrolyte disturbances and toxic levels of certain waste products normally eliminated by the kidneys. Patients may also develop fluid overload. Dialysis may be indicated in these cases.

Treatment of chronic renal failure depends on the degree of kidney function that remains. Treatment may include:

What is dialysis?

Dialysis is a procedure that is performed routinely on persons who suffer from acute or chronic renal failure, or who have ESRD. The process involves removing waste substances and fluid from the blood that are normally eliminated by the kidneys. Dialysis may also be used for individuals who have been exposed to or ingested toxic substances to prevent renal failure from occurring. There are two types of dialysis that may be performed, including the following:

Peritoneal dialysis. Peritoneal dialysis is performed by surgically placing a special, soft, hollow tube into the lower abdomen near the navel. After the tube is placed, a special solution called dialysate is instilled into the peritoneal cavity. The peritoneal cavity is the space in the abdomen that houses the organs and is lined by two special membrane layers called the peritoneum. The dialysate is left in the abdomen for a designated period of time which will be determined by your doctor. The dialysate fluid absorbs the waste products and toxins through the peritoneum. The fluid is then drained from the abdomen, measured, and discarded. There are three different types of peritoneal dialysis: continuous ambulatory peritoneal dialysis (CAPD), continuous cyclic peritoneal dialysis (CCPD), and intermittent peritoneal dialysis (IPD).

CAPD does not require a machine. Exchanges, often referred to as passes, can be done three to five times a day during waking hours. CCPD requires the use of a special dialysis machine that can be used in the home. This type of dialysis is done automatically, even while you are asleep. IPD uses the same type of machine as CCPD, but treatments take longer. IPD can be done at home, but usually is done in the hospital.

Possible complications of peritoneal dialysis include an infection of the peritoneum, or peritonitis, where the catheter enters the body. Peritonitis causes fever and stomach pain. Your diet for peritoneal dialysis will be planned with a dietitian, who can help you choose meals according to your doctor's orders. Generally:

You may have special protein, salt, and fluid needs.

You may have special potassium restrictions.

You may need to reduce your calorie intake, since the sugar in the dialysate may cause weight gain.

Hemodialysis. Hemodialysis can be performed at home or in a dialysis center or hospital by trained health care professionals. A special type of access, called an arteriovenous (AV) fistula, is placed surgically, usually in your arm. This involves joining an artery and a vein together. An external, central, intravenous (IV) catheter may also be inserted, but is less common for long-term dialysis. After access has been established, you will be connected to a large hemodialysis machine that drains the blood, bathes it in a special dialysate solution which removes waste substances and fluid, then returns it to your bloodstream.

Hemodialysis is usually performed several times a week and lasts for four to five hours. Because of the length of time hemodialysis takes, it may be helpful to bring reading material, in order to pass the time during this procedure. During treatment you can read, write, sleep, talk, or watch TV.

At home, hemodialysis is done with the help of a partner, often a family member or friend. If you choose to do home hemodialysis, you and your partner will receive special training.

Possible complications of hemodialysis include muscle cramps and hypotension (sudden drop in blood pressure). Hypotension may cause you to feel dizzy or weak, or sick to your stomach. Side effects are avoided by following the proper diet and taking medications, as prescribed by your doctor. A dietitian will work with you to plan your meals, according to your doctor's orders. Generally:

You may eat foods high in protein such as meat and chicken (animal proteins).

Long-term outlook for ESRD

People with ESRD are living longer than ever. Dialysis treatments (both hemodialysis and peritoneal dialysis) are not cures for ESRD, but will help you feel better and live longer. Over the years, ESRD can cause other problems such as bone disease, high blood pressure, nerve damage, and anemia (having too few red blood cells). You should discuss prevention methods and treatment options for these potential problems with your doctor.

Treatment Programs

Massachusetts General Hospital understands that a variety of factors influence patients' health care decisions. That's just one reason why we're dedicated to ensuring patients understand their diagnosis and treatment options. Because a single option might not serve all patients, we offer a wide range of coordinated treatments and related services across the hospital. Patients should consult with their primary care doctor or other qualified health care provider for medical advice and diagnosis information.

Pediatric ImagingThe Pediatric Imaging Program at Massachusetts General Hospital Imaging specializes in ensuring the safety and comfort of child patients while providing the latest technology and the expertise of specialized pediatric radiologists.

Transplant Psychiatry Program The Transplant Psychiatry Program in the Massachusetts General Hospital Transplant Center is an important part of the comprehensive and life-long care provided to transplant patients and donors.

Transplant Infectious Disease ProgramThe Transplant Infectious Disease Program, part of the Massachusetts General Hospital Transplant Center, is a part of the life-long care provided to organ, bone marrow and stem cell transplant recipients and others with increased risk for infections.

Resistant Hypertension ProgramThe Resistant Hypertension Program specializes in the evaluation, diagnosis and management of patients with resistant or difficult to treat hypertension.

Chronic Ambulatory Peritoneal Dialysis (CAPD) ProgramThe Peritoneal Dialysis Unit provides training and long term management for the patient who selects peritoneal dialysis as home therapy. Staffed by experienced peritoneal dialysis nurses, manual and automated home peritoneal dialysis is available.

Renal Associates ClinicRenal Associates provides services in general nephrology including diabetes, water and electrolyte disorders, kidney disease in pregnancy, urinary tract infections, and primary and secondary diseases of the kidney.