Abstract

Objective: To study the change of cardio-specific microRNA-208 levels in acute myocardial infarction patients and to explore the effect of microRNA-208 levels on the diagnosis of AMI. Methods: The consecutive subjects in roll in this study, including 42 patients with AMI, 22 patients with UA and 40 healthy subjects in our hospital from January 2013 to December 2013, microRNA-208 concentrations were measured with real-time reversetranscription PCR, all the clinical data of patients was collected. AMI patients were further divided into subgroups according to coronary arteries involved and primary PCI or not, Plasma microRNA-208 concentrations were analyzed. Serum Cardiac troponin I (cTnI) and creatine kinase-MB (CK-MB) concentrations were measured. Results: microRNA-208 expression was significantly higher in the AMI patients than that in the UA patients group and healthy controls immediately after admission (P<0.01). The Plasma microRNA-208 in the patients with AMI had a positive correlation with serum cTnI (P<0.01). MicroRNA-208 levels in AMI patients with twoand three-vessel coronary artery disease (CAD) were significantly higher than those in patients with single vessel CAD (P<0.05). microRNA-208 level at admission was significantly higher than that 24h after PCI in AMI patients (P<0.01). Conclusion: The circulation miRNA-208 was found to be linearly to myocardial damage and may prove to be a new biomarker of AMI.