Dr Tae H. Park is a little known ME/CFS doctor practicing in Seoul, South Korea. He claims a 90% recovery rate using a combination of weekly low dose intravenous gamma globulin (LD-IVIG), IV saline / salt water intake, aggressive rest therapy (ART), exercise restriction, sleep support, and strict nutrition. He's been mentioned (once?) on this forum before, but his protocol has not been discussed in depth in terms of theory.

Caveat: His work has not been replicated, peer reviewed, or formally published in any English journal I could find. 90% recovery is almost certainly an exaggeration. Still I find his protocol interesting.

Ample hydration:
- 2-3 litres of water with 2 tsp of salt.
Strict control of exercise and activities:
-No heavy lifting (anything using upper extremities – such as house cleaning) is prohibited.
- Walking is allowed if patient improves.
- If the patient feels any post-exertional malaise, then reduce the exercise.

How to have rest:
-Rest (like monks meditate)
-No loud music and no reading books.
-In acute stages, absolutely no exercise
-If anyone does exercise they may develop
cardiomyopathy or severe cardiac arrhythmia - even death.

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And his purported results:

Results of treatment:
90% of patients who were treated with the above regimens recovered and returned to work, or returned to school. Showed KS score from 40 to 90. The fatigue impact scale improved from 120 to 20-40. Especially, we found improvements in the cognitive functions. We found improvements in concentration and comprehension, but short-term memory is the last to recover.

IVIG - Dr Park uses low dose (1g) weekly IVIG (interestingly not SCIG). This is not a replacement or autoimmune dose, but perhaps its regularity, combined with its intravenous delivery mechanism, allows for build up in the body that helps reduce autoimmunity, autoinflammation, and improves pathogen clearance. The low dose likely saves on cost, infusion time, and reduces discontinuance due to side effects.

IV Saline - Administered at the same time as the IVIG is 500cc of IV saline. This is likely boosting blood volume allowing for better oxygenation of tissue and reduced OI. It is supplemented with high volumes of salt water throughout the week.

It seems that Dr Park is attacking the heart of the disease by modulating the immune system, boosting blood volume, and repairing the mitochondria (while supporting restorative biological processes of sleep and diet). If the IVIG results in reduced pro-inflammatory cytokines, fewer autoantibodies, and a lower pathogen load, that will certainly benefit the mitochondria by reducing the work they have to do. It may also reduce direct damage to key enzymes like PDH, or the ATP translocator protein by the aforementioned ongoing causal triggers. The same is true with increased oxygenation from better blood volume (from IV saline), and more energy directed at mitochondrial repair due to ART. Interestingly he uses prozac to support sleep which is known to have anti-enterovirus properties.

This is extremely low dose and am curious what the mechanism is?! My MCAS went into remission as soon as I began IVIG at 24 grams (this was low dose for me) and I was not up to the high dose IVIG (82 grams) for about 4-5 months. So, clearly there is some mechanism at play at all different doses but I wish I knew what it was!

This is extremely low dose and am curious what the mechanism is?! My MCAS went into remission as soon as I began IVIG at 24 grams (this was low dose for me) and I was not up to the high dose IVIG (82 grams) for about 4-5 months. So, clearly there is some mechanism at play at all different doses but I wish I knew what it was!

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I'm curious too. Dr Chia told me high dose isn't necessarily better though clearly for autoimmune it can be

I know from experience you can have a long and deep remission of symptoms but still have the disease. E.g. yoiu are generally well but able to trigger a distinctive episode of PEM if you, say, drink a lot, sleep very little and do endurance exercise in a short period of time. The disease is still there but just exceedingly mild.

I know from experience you can have a long and deep remission of symptoms but still have the disease. E.g. yoiu are generally well but able to trigger a distinctive episode of PEM if you, say, drink a lot, sleep very little and do endurance exercise in a short period of time. The disease is still there but just exceedingly mild.

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It doesnt stay there in everyone who has a remission. For me it was completely gone in my remission period, I was able to do everything I previously was before I got ME no issues at all

Interesting thing is doing only half of his protocol was what lead to me having a full remission for 2-3 years. I did ART in the same way he describes it (no watching TV while laying in bed, I listened to no music at all, silence, I completely rested body and mind).

Maybe if I'd been on the rest of this protocol the recovery using ART wouldnt have be so terribly slow (it took years of slow improvement with it before I was in full remission).

Looking at his protocol, I personally can see how it would work for lots of us and it eliminates also coexisting issues which may be preventing many of us from being able to heal just from proper done ART.

How many with ME/CFS are actually wrongly diagnosed as they only have autonomic issue such as POTS or another thing which has low blood volume but have ended up wrongly diagnosed with ME/CFS due to it?. Even for many ME/CFS people, the weekly saline not only helps them feel better for 1-2 days but maybe it can over time kick start their body into adjusting it normally. So this protocol could help heal that group.

As another said, its also a low histamine diet, so that would help other things.

" aspartame" Ive heard of a couple of different ones with CFS recover from cutting aspartame out of their diets

"High protein diets" can help some those who have insulin resistance (hyperinsulinemia). My allergist calls that condition the pandoras box of illnesses as it can cause so many symptoms to the point that people sometimes get diagnosed with CFS. Not many of us have been tested for that issue.

anyway, I know I had a remission just from only HALF of that protocol. (and i had been completely bedridden). Im sure this guy would be fixing many esp when he's telling people not to be doing housework (that can also mean then less chemical exposure etc) so hence certainly making sure they are more likely to rest.

If I was put on his protocol, I personally think I would likely go into remission again. Pity I dont have a supportive doctor to support that kind of thing and Im well aware Im doing way to much.

I think adding HBOT in between infusions (for additional tissue oxygenation), neurofeedback (for neuron growth), antivirals (based on onset and bloodwork), and mito/methylation supplements could make his approach even more more effective.

Very interesting.
Two personal observations :
- using upper extremities is what generally causes or worsens my PEM episodes
- I have recently adopted a similar diet cause I was having gut problems: It has helped a lot and I´m feeling better.

I'm not buying this. However i know nothing about LD-IVIG
The diet is not terrible so ok no harm trying it, the "sleep control" is ludicrous, anti depressants don't improve sleep quality, the hydration is really a joke but strikes me as intended to raise blood pressure (most people drink enough water containing fluids and get more salt then this already), the exercise restriction is common sense to us if a little extra, and people dropping dead from exercise is uncommon in ME/CFS, though it will make us worse.
The gamma globulin may be doing something, but the rest of it is rather silly

I know we are all desperate but lets not grasp onto anyone promising a "miracle" cure, talk is cheap, nonsense treatments are a dime a dozen and I look forward to some double blind placebo controlled testing and actual numbers

My red flag for any CFS practitioner is a high percentage rate of 'cured' or 'recovered' patients. As soon as I see unbelievably high numbers, I am extremely cynical about the doctor as a snake oil salesman who is mainly concerned with making money from desperate people.

Aside from the microdose of IV gamma goblulin/saline, there is nothing on his list that my husband and I haven't tried, or that a majority of those here on PR haven't tried. I don't have experience with the IVGG to be able to dismiss it, so maybe there is something to it. I know that some here on PR have gotten some improvements with that, but I don't remember anyone discussing going into CFS/ME remission as a result of it...perhaps I overlooked those posts?

I would be much less cynical if he didn't use a "90% remission rate" - hearing statistics like that is like flipping a kill switch for me. If that were true, I'd think the brilliant scientists currently working to crack the CFS mystery would be inundating his clinic for some insight. There is probably a good reason that he is not well-known.

*Sorry to be a Debbie Downer; CFS practitioners conning money from desperately sick people is a huge source of frustration for me, and I have become extremely skeptical of most of them at this point.

You guys are likely right regarding the 90% recovery rate being an exaggeration or misinterpretation.

What I think is interesting is the concept of removing the ongoing causal trigger through biomedical intervention, replenishing the body, and aggressive rest therapy to repair mitochondria / brain function.

After some searching around online on S.Korean websites, it appears that this doctor is highly controversial among the Korean CFS community. I found a Korean-language forum for CFS and they do not recommend him. They also mention that he's a bit infamous and controversial... I would definitely avoid going to see him. Just FYI, it's mentioned that the IVIG is done through a shot and each dose is roughly $100 (I'm guessing with insurance? I believe Korea has universal healthcare?). The treatment period is about 4-6 months.