The importance of the glutamine metabolism in colon cancer

The importance of glutamine metabolism for colon cancer was revealed by Masamitsu Konno, Ph.D, Masaaki Miyo, M.D. Ph.D, Masaki Mori, M.D. Ph.D and Hideshi Ishii, M.D. Ph.D. The aim of this study is to elucidate metabolic adaptation to nutritional stress and the role of the involved oncogenes in human colorectal cancer. The present study showed that the metabolism of colorectal cancer, distinct from that of pancreatic cancer, depended on genomic alterations, which previously have been uncharacterized, and was not restricted to KRAS mutation alone. Colorectal cancer can survive under the condition of glucose depletion while retaining TCA cycle activity. The cells' survival relies on a delicate balance between energy and reactive oxygen species (ROS) production. Glutamate dehydrogenase 1 (GLUD1) and SLC25A13 have pivotal roles under glucose-deprived conditions and are associated with tumor aggressiveness and colorectal cancer prognosis.

GLUD1 and SLC25A13 have pivotal roles in nutritional stress and are associated with tumor aggressiveness and poorer prognosis of colorectal cancer. These proteins may serve as new targets in the treatment of refractory colorectal cancer.

"We found that colorectal cancer cells survived under the condition of glucose depletion, and their resistance to such conditions depended on genomic alterations rather than on KRAS mutation alone. Metabolomic analysis demonstrated that those cells maintained TCA cycle activity and ATP production under such conditions. Furthermore, we identified pivotal roles of GLUD1 and SLC25A13 in nutritional stress. GLUD1 and SLC25A13 were associated with tumor aggressiveness and poorer prognosis of colorectal cancer. ", says Hideshi Ishii. "GLUD1 and SLC25A13 may serve as new targets in treating refractory colorectal cancer, which survives in malnutritional microenvironments."

How mouth microbes may worsen colorectal cancerBacteria commonly found in the mouth have been recently shown to worsen colorectal cancer in animals, but it has not been clear how these microbes make their way to the gut in the first place.

Pretargeted radioimmunotherapy may eliminate colorectal cancerAn emerging cancer therapy has colorectal tumors surrounded. Presenters at the 2016 Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging are unveiling a novel radioimmunotherapy that combines a cancer-seeking antibody with potent radionuclide agents, resulting in complete remission of colorectal cancer in mouse models.

Do you have colon cancer? Does someone you love? Did you know that eating differently, even after you are diagnosed, can lower your risk of dying? When you finish this book I want you to be able to tell me, in a minute or less, how you should eat, exercise, and supplement to lower your risk of dying as a diagnosed colon cancer patient. Last year when I when I was diagnosed I went looking for this book. With all the diet books, I figured someone had written a book specifically for newly diagnosed colon cancer patients. But there was nothing. I checked with my doctors and with the... View Details

- What Your Doctor May Not Tell You About Colorectal Cancer was published in Warner hardcover (0-446-53188-X) in 3/04. The book features a foreword by Katie Couric.- Dr. Pochapin made an appearance on the Today show in conjunction with the hardcover publication of this book. Previously, he had been chosen by Katie Couric to be the Medical Director of the Jay Monahan Center for Gastrointestinal Health, named in honor of Ms. Couric's late husband.- The author is an associate professor of clinical medicine at the Weill Medical College of Cornell University and Chief of Gastrointestinal... View Details

Colorectal cancer is one of the leading causes of cancer-related death in the world. Twenty-five percent of patients present with advanced disease and, despite complete surgical resection of early stage disease, 50% of patients relapse. The treatment of colorectal cancer has advanced rapidly in recent years, and controversies persist regarding optimal management (e.g. whether combination chemotherapy should be used first-line or in a staged fashion, how long to treat patients for and whether to use an intermittent or continuous schedule and whether to refer for a radical approach for advanced... View Details

This much-needed colorectal cancer resource is developed in consultation with a large national team of experts and endorsed not only by the American Society of Colon and Rectal Surgeons but also by the National non-profit the Colon Cancer Alliance. As with all of the Be a Survivor resources this book features candid testimonials by survivors. It is straightforward, easy-to-understand and contains objective and up-to-date information. The beautiful color photos and graphics enhance the learning process. Most importantly the book leaves the reader with a message of hope. The book addresses each... View Details

Although colorectal cancer is the third most common cancer found in men and women, you may be unaware of your risk and don't know what you can do to prevent this serious disease. You may be too embarrassed to ask your doctor about changes in your bowel habits or get screened for colorectal cancer. American Cancer Society's Complete Guide to Colorectal Cancer provides sound information and support if you are concerned about or diagnosed with colorectal cancer.

Choose This not That for Colon Cancer. This book provides comprehensive and actionable nutrition guidelines for how to reduce your risk, prevent and combat Colon (Colorectal) Cancer (CC). If you rather tackle health issues and risks through proper nutrition and lifestyle changes as opposed to prescription drugs and other typical medical treatments, then this book is for you. Here are the highlights and what makes this publication unique and different from your other options:

A look-up table for over 800 different types of food and their suitability for CC Health... View Details

Management options for patients with colorectal cancer have undergone d- matic changes over the past decade. Whereas at the start of 1996 only one drug, 5-Fluorouracil, was available for the treatment of this disease, a mere 10 yr later, six drugs are licensed for use in colorectal cancer, and others are in the late phases of clinical development. Likewise, surgical and ablative options, as well as an array of supportive medications, have shown substantial progress and undergone a dramatic proliferation over the past decade. With the increased number of therapeutic options from which to... View Details

Colorectal cancer has for more than two decades served as the paradigm for the multi-step concept of cancer initiation and progression. Perhaps more than any other organ site, cancer of the colon is extensively characterized at the molecular level. We are now entering a time when molecular classification, rather than histologic classification, of cancer subtypes is driving the development of clinical trials with emerging targeted therapies. The book will focus on the progression from the identification of mutations that drive colorectal cancer initiation and progression to the search for... View Details

This book presents an Asian perspective on how the treatment of colorectal cancer can be optimized and standardized in ways that take into account technological advances and the trend towards individually tailored therapy. Readers will find careful, well-illustrated descriptions of the standard surgical techniques for rectal cancer and colon cancer that have contributed to recent improvements in 5-year survival rates in the Asia-Pacific region, where the incidence of colorectal cancer has been rising alarmingly due to lifestyle changes. The vital role now being played by minimally... View Details

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