Franklin began his television career as a writer and producer for Laverne & Shirley and Bosom Buddies. Franklin pitched his own show to ABC called "House of Comics" which featured three comics living together.[citation needed] ABC was looking for a family sitcom, so Franklin added children and the idea evolved into the show Full House, which ran on the ABC network from 1987 to 1995.

On April 20, 2015, Netflix announced the streaming service would pick-up thirteen episodes of Fuller House, a sequel to Full House.[6] Netflix also announced Franklin would oversee the production along with Robert L. Boyett and Thomas L. Miller.[6] All 13 episodes of the first season premiered on February 26, 2016.[7][8] The series, which has been a major hit for Netflix is currently in its fifth season.

In February 2018, Franklin was fired from Fuller House after complaints about verbally abusive and vulgar language in the writers' room and on the set of the series.[9].

In June 2019, The Hollywood Reporter revealed details of a probe made by Warner Brothers that included interviews with eight Fuller House staffers who commented that Franklin would talk about orgies he had over the weekend, claims that Franklin had his assistant request that all the writers come to his mansion and they were reminded multiple times to bring their bikinis. Franklin complaining about having to hire directors who were women or people of color, expressing preference for male writers, apologizing to his staff for not dating Jewish women, and describing female directors as "all the same" and making sexualized comments.[10] In one occasion, Frankin was attributed to saying "She is probably going to be pregnant next season, I wish I could make all the women on my staff get hysterectomies." and in another comment about an underaged girl, "She's one nose job away from a good f***."[10]