Browse our anti-CD81 (CD81) Antibodies

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anti-CD81 Molecule Antibodies (CD81)

On www.antibodies-online.com are 462 CD81 Molecule (CD81) Antibodies from 35 different suppliers available. Additionally we are shipping CD81 Proteins (20) and CD81 Kits (10) and many more products for this protein. A total of 504 CD81 products are currently listed.

More Antibodies against CD81 Interaction Partners

Pig (Porcine) CD81 Molecule (CD81) interaction partners

Mouse (Murine) CD81 Molecule (CD81) interaction partners

The species-specific traits in CD9 and CD81 distribution during sperm maturation were compared between mice and humans. A mutual position of CD9/CD81 is shown in human spermatozoa in the acrosomal cap, however in mice, CD9 and CD81 occupy a distinct area.

CD81-Rac interaction exerts an important regulatory role on the innate and adaptive immunity against bacterial infection and suggests a role for CD81 in the development of novel therapeutic targets during infectious diseases.

Plasmodium yoelii sporozoite rhoptry discharge occurs only in the presence of CD81, providing the first direct evidence for a role of CD81 during sporozoite productive invasion.

In vitro myotubes lacking CD9P-1 or both CD9 and CD81 fuse with a higher frequency than normal myotubes

Data suggest that GPC3 down-regulates hepatocyte proliferation by binding to hedgehog (HH) and down-regulating the HH signaling pathway and binding with CD81, thus making it unavailable to bind to Hhex and causing its nuclear translocation.

CD81 interacts with the T cell receptor to suppress signaling.

Data show that effective B cell receptor (BCR) signaling requires collaboration with the coreceptor CD19 organized by the CD81-tetraspanin network.

results indicate that the CD19/CD81 complex interacts with CD38 but this interaction is not required to induce proliferation in mouse B lymphocytes

data indicate that CD81 plays a significant role in the final stages of RPE development, controlling cell number and overall developmental pattern

CD81 gene is maternally imprinted, with preferential expression from the paternal allele.

CD81 plays a negative role in B cell activation in vitro and in vivo.

CD81 expression by T cells is critical for their induction of IL-4 synthesis by B cells

Infertility of CD9-deficient mouse eggs is reversed by mouse CD81

the role of CD81 in the regulation of astrocyte and microglial number, perhaps by regulating cell proliferation by a contact inhibition-dependent mechanism.

Data show that CD81, a putative receptor for hepatitis C virus, is required on hepatocytes for human Plasmodium falciparum and rodent Plasmodium yoelii sporozoite infectivity.

CD81 affects expression of its associated partner CD19 beginning at a B-cell postendoplasmic reticulum compartment where CD81 is necessary for normal trafficking or for surface membrane stability of CD19.

The species-specific traits in CD9 and CD81 distribution during sperm maturation were compared between mice and humans. A mutual position of CD9/CD81 is shown in human spermatozoa in the acrosomal cap, however in mice, CD9 and CD81 occupy a distinct area.

results demonstrate that the interaction of CD81 with SAMHD1 controls the metabolic rate of HIV-1 replication by tuning the availability of building blocks for reverse transcription, namely dNTPs.Together with its role in HIV-1 entry and budding into host cells, the data indicate that HIV-1 uses CD81 as a rheostat that controls different stages of the infection

CD9-CD81 blockage reduces exosome-mediated HIV-1 entry.

CD81 is preferentially expressed in first trimester human placentas and progressively down-regulated with gestation advance in normal physiological conditions. CD81 up-regulation is detected in trophoblasts and cells in the villous core, and maternal sera of patients with early-onset severe preeclampsia.

Results from crystallography and molecular dynamics of CD81 long-extracellular loop (LEL) show that its flexibility is an inherent molecular property likely to be tuned by variation in pH and redox conditions. This tuning mechanism would explain the priming role ascribed to CD81LEL in rendering the virus-receptor complex fusogenic during cell entry.

A new link between HCV receptor molecules and the hepatocyte glycocalyx, namely, CD81 and Synd-1.

Study used molecular dynamics simulations to gain insights into the role of local conformational flexibility in nanodomain formation in the plasma membrane, using the tetraspanin molecule CD81 as a model; suggest that exposing a flexible domain of CD81 enables binding to interaction partners by circumventing the restriction of orientation and conformational freedom of membrane proteins

The findings suggest that, in contrast with previous models, the ligand-binding site of integrin alphaVbeta3, binds to the constant region (helices A and B) of the EC2 domain of CD9, CD81, and CD151 antigens.

Studies have shown that CD81 regulates cell migration and invasion, and has therefore been implicated in tumor growth, cancer progression and metastasis. CD81 is expressed in most types of cancer, and the overexpression or down-regulation of this molecule has been correlated with either good or bad prognosis. [review]

The transmembrane segments of CD81 pack as two largely separated pairs of helices, capped by the large extracellular loop (EC2) at the outer membrane leaflet. The two pairs of helices converge at the inner leaflet to create an intramembrane pocket with additional electron density corresponding to a bound cholesterol molecule within the cavity.

Results suggest that the CD81 antigen (CD81) expressed by B cells has differential effects on B cell proliferation or apoptosis according to Epstein-Barr virus (EBV) infection and the expression level of CD81.

These observations confirm the role of CD81 in liver-stage malaria and question that of scavenger receptor class B member 1.

CD81 Antigen Profile

Antigen Summary

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. This protein appears to promote muscle cell fusion and support myotube maintenance. Also it may be involved in signal transduction. This gene is localized in the tumor-suppressor gene region and thus it is a candidate gene for malignancies.