Like a hole in the head: The return of trepanation

IN THE early 1960s, a young Russian neurophysiologist called Yuri Moskalenko travelled from the Soviet Union to the UK on a Royal Society exchange programme. During his stay, he co-authored a paper published in Nature. "Variation in blood volume and oxygen availability in the human brain" may not sound subversive, but it was the start of a radical idea.

Decades later, having worked in Soviet Russia and become president of the Sechenov Institute of Evolutionary Physiology and Biochemistry at the Russian Academy of Sciences in St Petersburg, Moskalenko is back in the UK. Now collaborating with researchers at the Beckley Foundation in Oxford, his work is bearing fruit.

And strange fruit it is. With funding from the foundation, he is exploring the idea that people with Alzheimer's disease could be treated by drilling a hole in their skull. In fact, he is so convinced of the benefits of ...

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