Before running Combofix, temporary disable any firewall(s) shield(s) ect...to prevent any conflicts with Combofix. After Combofix is done scanning, it will create a log, for futher instructions, save and paste the results by Attach File, or by Code Snippet so other experts can take a look at it. Once after the log looks clean, you may enable your firewall(s) shield(s) ect. Combofix will disconnect your machine from the Internet. Your Internet connection will be automatically restored just before Combofix completes its scan. If Combofix runs into problems, your Internet connection can be manually restored by restarting your machine.

You'll might need to rename the file before saving to your desktop so it will not be blocked.

I agree with what joefreedom said, but you should note that turning off System restore deletes all your restore points. This is important because restore points contain protected files which will not be deleted by any program no matter what it says. Once SR is off the points are deleted, but as has been said, you should run your software to be sure.

Before doing this make sure your computer reboots. Try to make sure your system is clean of viruses except in system restore. Do NOT follow these directions if you have tried to restore to an earlier time before you were infected. An infected restore point is better than none at all. But once you have a clean machine, the following procedure is the ONLY way I know of to clean your restore points because they are protected files.

No matter what your software says it is doing it cannot clean your restore points.

WARNING: This will DELETE ALL your system restore points

Disable System Restore:
Click Start, right-click My Computer, and then click Properties.
In the System Properties dialog box, click the System Restore tab.
Click to select the Turn off System Restore check box. Or, click to select the Turn off System Restore on all drives check box.
Click OK.
When you receive the following message, click Yes to confirm that you want to turn off System Restore:
"You have chosen to turn off System Restore. If you continue, all existing restore points will be deleted, and you will not be able to track or undo changes to your computer.
Do you want to turn off System Restore?"
After a few moments, the System Properties dialog box closes.

Reboot your system

Follow the above steps to reenable system restore

Create a manual restore point:
click the start button
all programs
accessories
system tools
system restore

choose to create a restore point and follow the prompts - name it appropriately