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Description

The inhibition of angiogenesis is an effective mechanism of slowing down tumor growth and malignancies. The process of induction or pro-angiogenesis is highly desirable for the treatment of cardiovascular diseases, wound healing disorders, and more. Efforts to understand the molecular basis, both for inhibition and induction, have yielded fascinating results.

Originally published by Bentham and now distributed by Elsevier, Anti-Angiogenesis Drug Discovery and Development, Volume 2 is an compilation of well-written reviews on various aspects of the anti-angiogenesis process. These reviews have been contributed by leading practitioners in drug discovery science and highlight the major developments in this exciting field in the last two decades. These reader-friendly chapters cover topics of great scientific importance, many of which are considered significant medical breakthroughs, making this book excellent reading both for the novice as well as for expert medicinal chemists and clinicians.

Key Features

Edited and written by leading experts in angiogenesis drug development

Reviews recent advances in the field, such as coverage of anti-angiogenetic drugs in ovarian cancer

Reports current strategies and future outlook for anti-angiogenic therapy and cardiovascular diseases

Readership

Medicinal Chemistry and Pharmaceutical researchers

Table of Contents

Preface

List of Contributors

Chapter 1: Mechanism of Controlling Blood Vessel Growth and Development and Identification of Therapeutics Against Pathological Angiogenesis

Abstract

Introduction

An Historical Overview of Angiogenesis

Types of Angiogenesis

The Mechanism of Normal Angiogenesis

Tumor Induced Angiogenesis

Assays for Angiogenesis

Mechanism of Angiogenesis Inhibition

Inhibitors of Growth Factors and Receptors

An Overview of Anti-Angiogenic Therapy

Conclusion

Acknowledgements

Conflict of Interest

Chapter 2: Development of In Vitro Method for Assaying Anti-Angiogenic Effect of Drugs

Abstract

Introduction

Collagen Gel Culture of Aortic Explant

Capillary Tube Formation

Immunohistochemistry of Angiogenic Factors

Adhesive Molecules (Integrins)

CD133 (Hematopoietic Stem/Progenitor Cell Marker)

Gene Array Analysis

Anti-Angiogenic Drugs

Collagen Gel Culture as an in Vitro Model for Studying Vascular Injury

Collagen Gel Culture of Various Organs

Conclusion

Acknowledgements

Conflict of Interest

Disclosures

Chapter 3: Clear Cell Renal Cell Carcinoma as a Model of Pathological Angiogenesis: Which Actors to Target for Treatment?

Abstract

Introduction

Targeted Therapies in Use

Emergent Molecules in Phase III Clinical Trials

Emergent Molecules in Phase II Clinical Trials

Identification of Predictive Biomarkers of the Efficiency of Anti-Angiogenesis Treatments

Details

About the Editor

Muhammad Choudhary

Muhammad Choudhary, PhD, is a Professor of the International Center for Chemical and Biological Sciences, (H. E. J. Research Institute of Chemistry and Dr. Panjwani Center for Molecular Medicine and Drug Research), University of Karachi, Pakistan. He is a member of the Royal Society of Chemistry, London; American Chemical Society; International Union of Pure and Applied Chemistry (IUPAC); American Society of Pharmacology; New York Academy of Sciences; Federation of Asian Chemical Societies (FACS); and he serves on the executive board of the Asian Network of Research on Anti Diabetic Plants (ANRAP). He is a recipient of the National Book Foundation's Prize for Chemistry and the Economic Cooperation Organization (ECO) Award in Education, 2006, given by the President of Azerbaijan. He has published 24 books, more than 570 papers, and 20 patents.

Affiliations and Expertise

Professor, International Center for Chemical and Biological Sciences, (H. E. J. Research Institute of Chemistry and Dr. Panjwani Center for Molecular Medicine and Drug Research), University of Karachi, Karachi, Pakistan

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