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Best JS API's/Frameworks out there for a new online App?

I know it's a pretty general question, but I was wondering what's everyones view on what are some of the best JS API's/Frameworks out there for a new online App? I'm still undecided if whether it will need to be responsive, or if I'll code a native version of the App but for now I'm just interested in learning about what my options are in regards to building an online App with JS.

Access to database functions are very important, and I'm already a fan of Parse.com

you can store data like parse.com for free with a google spreadsheet.
they seem to be targeting native apps.

unless you need ultra-responsive UI for a game, you can probably build the same app using html5.

there are a million frameworks out there, from low-level jQuery to high-level abstractions like polyfills for <audio>, drawing APIs like processing and raphael, and semi-automatic data binding like knockout.js.

what's the best?
it all depends on what app you're building.

what's the best tire size for a vehicle?

Create, Share, and Debug HTML pages and snippets with a cool new web app I helped create: pagedemos.com

you can store data like parse.com for free with a google spreadsheet.
they seem to be targeting native apps.

unless you need ultra-responsive UI for a game, you can probably build the same app using html5.

there are a million frameworks out there, from low-level jQuery to high-level abstractions like polyfills for <audio>, drawing APIs like processing and raphael, and semi-automatic data binding like knockout.js.

what's the best?
it all depends on what app you're building.

what's the best tire size for a vehicle?

Let's say for example I was building a app like linkedin what JS API would be best for that?