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Abstract

Background

Ameloblastoma is an odontogenic neoplasm characterized by local invasiveness and tendency
towards recurrence.

Aims

Studying the role played by EGFR, CD10 and Ki67 in the recurrence of ameloblastoma.

Methods

This study was carried out on 22 retrospective cases of mandibular ameloblastoma from
the period from Jan 2002 to Jan 2008 with follow up period until Jan 2011 (3 to 8
years follow up peroid). Archival materials were obtained from pathology department,
Mansoura university. Paraffin sections of tumor tissue from all cases were submitted
for routine H&E stains and immunohistochemistry using EGFR, CD10 and Ki67 monoclonal
antibodies. Statistical analysis using of clinical data for all patients, tumor type,
EGFR, CD10 and Ki67 expression in relation to recurrence were evaluated.

Results

Among the 22 cases, 10 cases were males and 12 were females with sex ratio 1:1.2.
Age ranged from 34 to 59 years old with a mean age 44.18 year. Five cases showed local
recurrence within studied period and proved by biopsy. No statistically significant
relation was found between local recurrence and patient age, tumor size, tumor type,
EGFR expression. There was a significant relation between CD10 expression as well
as Ki67 labelling index and recurrence (P value = 0.003, 0.000 respectively).

Conclusion

Evaluation of CD10 and Ki67 status together with conventional histological evaluation
can help in providing more information about the biologic behavior of the tumor, while
EGFR could be a target of an expanding class of anticancer therapies.

Since ameloblastomas are EGFR-positive tumors, anti-EGFR agents could be considered
to reduce the size of large tumors and to treat unresectable tumors that are in close
proximity to vital structures.