Axonal BACE1 dynamics and targeting in hippocampal neurons: a role for Rab11 GTPase

Conclusions of this paper:
Our results reveal novel information on dynamic BACE1 transport in neurons, and demonstrate that Rab11-GTPase function is critical for axonal sorting of BACE1. Thus, we suggest that BACE1 transcytosis in endosomes contributes to presynaptic BACE1 localization.