I use CMD space a million times a day to find files, launch apps, etc.

Wouldn't it be cool if I could press a keyboard combination and get a box to send a tweet? I know I can do it through notification center but I'm looking for a method that doesn't require me to leave the keyboard.

That's definitely a step in the right direction. But unfortunately, I have to have the Twitter app running. But that's not a huge deal. Unless someone can come up with a way to do exactly that without the app running, then I will give you the answer shortly.
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cbmeeksJul 28 '12 at 21:53

How about using a shortcut to run an AppleScript?
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MosheJul 28 '12 at 21:53