A Children's Oncology Group Protocol for Collecting and Banking Osteosarcoma Specimens

Trial Information

A Children's Oncology Group Protocol for Collecting and Banking Osteosarcoma Specimens

OBJECTIVES:

- To collect biological specimens from patients with osteosarcoma at Children's Oncology
Group (COG) institutions.

- To provide a repository for long-term storage of osteosarcoma-related biological
materials.

- To make these specimens available to qualified researchers to understand the biology of
osteosarcoma and correlate these results with the patients' clinical data.

OUTLINE: After the initial submission of blood samples, patients may undergo open or closed
biopsy in order to obtain fresh and frozen tissue samples as well as paraffin embedded
material. Patients who are enrolled at the time of initial diagnosis but then have a
definitive surgery or develop recurrent disease may submit additional samples (paraffin
block, frozen and fresh tumor tissue, or slides together with blood samples). Autopsy tumor
samples may also be submitted.

Inclusion Criteria

DISEASE CHARACTERISTICS:

- All osteosarcoma patients seen at COG institutions are eligible, including the
following:

- Newly diagnosed patients

- Patients with recurrent disease who were not enrolled at the time of diagnosis

- The following specimens from the initial biopsy (and/or definitive surgery if an
up-front resection is performed) are required:

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