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Made with Organic Red Yeast Rice Non-GMO Maintains
Healthy Cholesterol Levels* CoQ10 Improves Heart Health* Our Red Yeast Rice is made according to traditional methods. Its benefits are recommended for adult men and postmenopausal women who are interested in maintaining ...

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This scientific independent research is provided by Aisle7 and is for informational use only. GNC provides this information as a service but does not endorse it. Likewise, Aisle7 does not recommend or endorse any specific products.

For an herb, supported by traditional use but minimal or no scientific evidence. For a supplement, little scientific support.

Our proprietary "Star-Rating" system was developed to help you easily understand the amount of scientific support behind each supplement in relation to a specific health condition. While there is no way to predict whether a vitamin, mineral, or herb will successfully treat or prevent associated health conditions, our unique ratings tell you how well these supplements are understood by the medical community, and whether studies have found them to be effective for other people.

For over a decade, our team has combed through thousands of research articles published in reputable journals. To help you make educated decisions, and to better understand controversial or confusing supplements, our medical experts have digested the science into these three easy-to-follow ratings. We hope this provides you with a helpful resource to make informed decisions towards your health and well-being.

This supplement has been used in connection with the following health conditions:

Dose: Extracts providing at least 50 mg per day chlorogenic acids
While drinking regular coffee or other sources of caffeine may slightly raise blood pressure,1 coffee also contains chlorogenic acids that may have a blood pressure-lowering effect, according to animal research.2 However, a double-blind study found that a substance produced by roasting coffee can inhibit this blood pressure-lowering effect, and by removing this substance, coffee lowered blood pressure.3 This suggests that extracts of unroasted ("green") coffee that are high in chlorogenic acids might help lower blood pressure. A double-blind trial found that eating soups containing green coffee extracts providing at least 50 mg per day chlorogenic acids lowered blood pressure significantly better than soup containing no green coffee extracts in people with mild hypertension, but that lower amounts of green coffee extracts in the soup were not effective.4 A double-blind trial of green coffee extract supplements containing 140 mg per day of chlorogenic acids reduced systolic blood pressure by an average of 10 mm Hg and diastolic blood pressure by an average of 7 mm Hg in people with mild hypertension.5 One controlled trial found no blood pressure-lowering effect of green coffee extract supplements in people with normal blood pressure.6

Dose: Extract providing 400 to 450 mg of chlorogenic acids per day
Animal research suggests that green coffee extract and its major component, chlorogenic acid, may help with weight loss and reducing abdominal fat.1, 2 An uncontrolled human study found that people who drank 750 ml per day of coffee containing green coffee bean constituents for four weeks ate fewer calories and lost weight.3 In a controlled study, overweight people who drank a coffee beverage containing green coffee extract (providing 400 to 450 mg of chlorogenic acids per day) for 12 weeks lost an average of about 12 pounds and 3.6% body fat compared to less than 4 pounds and an insignificant amount of body fat lost by people who drank a similar amount of coffee without added green coffee extracts.4 Another controlled study reported a statistically significant 11 pound weight loss after 60 days when overweight people took 400 mg per day of green coffee extracts (providing 180 mg of chlorogenic acids per day), compared to about a five pound loss in people taking a placebo.5 The green coffee extracts group also significantly raised their ratio of lean body tissue to body fat compared to the control group. However, since these studies lasted only 12 weeks or less, more research is needed to determine if green coffee extract can help people accomplish long-term weight loss. In addition, at least one human study supporting green coffee extract's effect on weight loss has been retracted due to methodological problems, raising suspicion about research relating to green coffee extract and weight loss.

4. Thom E. The effect of chlorogenic acid enriched coffee on glucose absorption in healthy volunteers and its effect on body mass when used long-term in overweight and obese people J Int Med Res 2007;35:900-8.

Dose: Refer to label instructionsDrinking either regular or decaffeinated coffee has been associated with reduced type 2 diabetes risk in several preliminary human studies.1 Test tube studies suggest that chlorogenic acid, a primary constituent found in both coffee and in green coffee extract may inhibit glucose production by the liver,2 which could theoretically lead to lower blood sugar. An animal study found that green coffee extract also prevented the reduction in insulin sensitivity caused by a high-fat diet.3 No human studies have tested the effect of green coffee extract on reducing risk of diabetes or improving insulin sensitivity, but a double-blind trial found that healthy people who drank a sweetened coffee beverage containing green coffee extract (providing 400 to 450 mg of chlorogenic acids) had lower blood sugar during the following two hours compared to when they drank the same coffee beverage without added green coffee extract.4 More research is needed to determine whether green coffee extract can help prevent or treat type 2 diabetes.

4. Thom E. The effect of chlorogenic acid enriched coffee on glucose absorption in healthy volunteers and its effect on body mass when used long-term in overweight and obese people J Int Med Res 2007;35:900-8.

Parts Used & Where Grown

Coffee is grown extensively throughout the world for its seeds (or beans), especially in the warm regions of the Central and South America, Asia, Africa, and the Pacific Islands.

The information presented by Healthnotes is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. Self-treatment is not recommended for life-threatening conditions that require medical treatment under a doctor's care. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires June 2017.