AFP: Multi-system high yielding topic for NEET PG, AIIMS & JIPMER

NEET PG toppers are selective in their preparation

When is the best time to know the selection for medical PG entrance exams? Near to NEET PG or earlier? It is best to know the important topics as you go along. It is not the name of the topics that is important, it is the relevance in clinical practice that makes it important for exams. Bring the H-Y-Ts into discussion with friends, colleagues and on chat rooms. Often we do the opposite. We speak about rare questions in the chat rooms!

Alpha Feto Protein (AFP) : H-Y-T 002

Answer the MCQs below and see the popular answers. Don’t forget to check the correct answers and explanations.

Which of the following is TRUE about AFP as a tumour marker in patients with germ cell tumour?

A. AFP concentration is increased in nonseminoma

481 Candidates

B. AFP concentration is increased only in seminomas

82 Candidates

C. High AFP levels should be treated for seminomas

55 Candidates

D. The half-life of AFP is 24–36 hours

36 Candidates

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Ans. A. AFP concentration is increased only in nonseminoma. Although hCG concentrations may be increased in both nonseminoma or seminoma histology, the AFP concentration is increased only in patients with nonseminoma.

The presence of an increased AFP level in seminoma indicates that an occult nonseminomatous component exists, and the patient should be treated for nonseminomatous GCT as well.

The half-life is 24–36 h for hCG and 5–7 days for AFP. AFP and hCG should be assayed serially during and after treatment.

AFP is persistently increased in all of the following, EXCEPT?

A. Chronic liver disease

63 Candidates

B. Cirrhosis

118 Candidates

C. Hepatocellular carcinoma

56 Candidates

D. None of the above

302 Candidates

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Ans. D. None of the above

AFP may be transiently increased with acute liver disease and persistently increased in chronic liver disease, cirrhosis and hepatocellular carcinoma. In hepatocellular carcinoma, elevated AFP levels serve as a tumor marker with a 40% to 80% sensitivity.

A 29-year-old primigravida presents with elevated maternal serum AFP. Acetylcholinesterase and AFP are positive in amniotic fluid. All of the following are likely diagnosis, EXCEPT?

A. Congenital myasthenia gravis

286 Candidates

B. Open neural tube defect

62 Candidates

C. Oesophageal atresia

44 Candidates

D. Epidermolysis bullosa

66 Candidates

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Answer A. Congenital myasthenia gravis. If the amnionic fluid AFP level is elevated, like in this scenario an assay for acetylcholinesterase is performed. A positive result is considered diagnostic of a Neural Tube Defect. Acetylcholinesterase leaks directly from exposed neural tissue into the amnionic fluid. The overall sensitivity of amniocentesis is approximately 98 percent for open NTDs.

G2M High Yielding Topics for Medical PG will cover the most important, frequently repeated and the most likely topics and new advances in a series. G2M H-Y-T series offers guidance for NEET PG 2018, AIIMS 2018, DNB 2018 and JIPMER 2018 exams and leads to use the platinum access.

There are 87 H-Y-MCQs on AFP in PLATINUM ACCESS. It is highly recommended to cover this HY topic in the next 2 days with Platinum Access.

How to use platinum access to cover more from High Yielding Topic (H-Y-T) 002: AFP?

You can create a ‘MY TOPIC‘ in the study panel and name it ‘AFP‘. Use keyword search to create a HYT. Search for ‘AFP’ and click create test. This will be saved as a HYT for your future revision too. Get platinum access instant subscribe. Note: you may find few questions from AFP (acute flaccid paralysis) this is an important topic too. Don’t skip!

How to create HYTs on Study Panel for NEET PG, AIIMS PG, JIPMER and DNB exams?

Make sure you have selected PLATINUM ACCESS as package on Study Panel.