Playing herself, Griffin will trigger some insecurity issues when she considers moving into an apartment across from Maddie (Alley) and the paparazzi follow. Fearing she'll have to play second fiddle to the celebrity in her own building, Maddie goes to great (and ridiculous) lengths to keep Griffin from moving in.

"I'm sorry to say this episode is based on several actual attempts in my life to move in next door to someone who has been featured prominently in my act," Griffin told TheWrap exclusively.

"Ring a bell Ryan Seacrest and Oprah? Just kidding! It really will be a pleasure and an honor to work beside such a funny and talented actress - who as it turns out actually gets the joke," she continued.

Griffin's TV credits include numerous standup specials and two seasons of late-night talk show "Kathy." She also won two Emmys for her Bravo reality series, "My Life on the D-List," starred on Brooke Shields' NBC sitcom "Suddenly Susan," and has several guest-starring credits.

Other season 1 guest stars will include John Travolta, Alexander, George Wendt, Cloris Leachman, Chenoweth and Kristen Johnston.

On the sitcom premiering Dec. 4, Alley plays Broadway star Maddie Banks, whose life gets turned upside down when the son she gave up for adoption re-enters her life.