Since the founding of our laboratory, we have committed our research program to determining the mechanisms that cause motor neuron degeneration in Amyotrophic Lateral Sclerosis (ALS). As our understanding of these mechanisms improves, we gradually seek to translate our discoveries into new therapeutic options for patients.

Based on our initial successes in contributing to the understanding of motor neuron disease, we have now begun to expand our interests, applying similar strategies to the study of psychiatric conditions in collaboration with The Stanley Center at The Broad Institute.