Investigation of Novel Drug Delivery Systems and Processing Technologies in New State-of-the-Art Research Laboratories

The primary focuses of Prof. Serajuddin’s research are (1) the development of novel drug delivery systems, especially for poorly water-soluble drugs, and (2) the innovation in processing technologies for solid dosage forms. The current research projects in two modern state-of-the art research laboratories include:

Development of liquid and solid self-emulsifying drug delivery systems

Development of high-energy solids for enhancing dissolution rate of drugs

Supersolubilization and amorphization of drugs by acid-base interaction

Construction of a Ternary Phase Diagram of a Poorly Water Soluble Drug in Presence of Hydrophilic Polymer and a Surfactant: Itraconazole, Soluplus® and Kolliphor® P 188, St. John’s University, Charles I. Jarowski Symposium, 2013

It is the Brazil Scientific Mobility Program – Science without Borders. One-year program to study abroad in a university in USA, with a required academic training during the summer, sponsored by Brazilian government.

Yining Shao

Undergraduate Student

Research at St. John’s (Jun 2013- Sep 2013)

Solid dosage forms design, with a focus on properties of silicates and using them as a loading medium for self-emulsifying delivery systems. Analysis of the lipid carrying potential of various silicates and meta-silicates with respect to their physical properties.

Industrial Pharmacy Innovation Laboratory, Facilities & EquipmentThe Industrial Pharmacy Innovative Laboratory was built in 2011 with generous donations from alumni and friends. It is equipped with modern state of the art equipment for drug delivery research and pharmaceutical processing.

Shah AV, Serajuddin ATM. Development of solid self-emulsifying drug delivery system (SEDDS) I: use of poloxamer 188 as both solidifying and emulsifying agent for lipids. Pharm Res. 2012;29(10):2817-2832.

To investigate effect of the fatty acid chain length on Nanoemulsion Formation and Drug Solubility.

A Comparative Evaluation of Mono-, Di- and Triglyceride of Medium Chain Fatty Acids by Lipid/Surfactant/Water Phase Diagram, Solubility Determination and Dispersion Testing for Application in Pharmaceutical Dosage Form Development

Development of solid self-emulsifying drug delivery system (SEDDS) I: use of poloxamer 188 as both solidifying and emulsifying agent for lipids

Publications

Shah AV, Serajuddin ATM. Development of solid self-emulsifying drug delivery system (SEDDS) I: use of poloxamer 188 as both solidifying and emulsifying agent for lipids. Pharm Res. 2012;29(10):2817-2832.