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10/20/2014 12:00PM

DNA Protects Hispanic Women From Breast Cancer

A genetic trait protects many Hispanic women from breast cancer, speech therapists are using ultrasound imaging to help fix the hardest speech problem in children and nearly two million people ran a half-marathon last year. Photo: Getty

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... the discovery of a genetic trait to protect some women against breast cancer could lead to more effective testing for women at risk welcomes your Monday lunch break everyone I'm tiny Rivera oh ... a genetic trait may protect Hispanic women from developing breast cancer by as much as eighty percent ... according to a new study published today with analysis were towing now by doubly SJ senior science reporter leaflets ... we thank so much for being with that ... it's always a pleasure can you briefly summarize the findings for us ... well ... today researchers at the University of California San Francisco Medical geneticists and cancer specialists ... are reporting that they have finally found ... the reason why a Mini Latina Hispanic women ... in the US um have faced a dramatically lower risk ... of developing breast cancer ... on and the reason is ... one single character ... of DNA ... in the three billion ... biochemical letters of genetic code to make up for ... human genome just one single variation of great ... long at an Listerine of the genetic code which is kind of astonishing into a Swan that such a small variation can make it such an enormous difference to health and well-being ... and to that they can detect an absolutely and often come from both sides of the family ... it can decrease the chance of getting breast cancer by as much and opens his eyes much to lower the risk by as much as eighty percent credible now we're talking about aam a a genetic variant ... that is not inherited equally by all ... women of Hispanic or Latino descent yes so what's one that are most likely to happen yet it appears to trace the origins of the best they can tell that the moment Mrs research is still a balding ... they've traced it to ... the indigenous ... American populations of Central and South America ... so ... how old are likely you were ... that is if you if you inherit this is completely dependent on ... you know what were your parents come from where their grandparents come from ... you know we talk about family histories of crisp s cancer is such ... a new way ethnicities course family history writ large store now and ... if you are of up ... Latin American descent ... as opposed to set of more European Spanish descent ... then you are more likely to set of had this to ... Guardian genetic while I was this and my mother is Cuban shares the resisters and out of the four women still got breast cancer so clearly our family ... is not blessed with this genetic tree it's the ... unfortunately but I guess what it is more if you haven't indigenous background which doesn't happen to be the case in my family ... well I'm sorry for that yes um well they think the ... I thought that something is excellent ... um but so what can we do now with this information how can researchers use this genetic trait that that identified to help other women ... well that's an excellent question of course very first and they need to do is to confirm the Sentosa really do the analysis new experiments ... to better understand what this ... tiny genetic variation is doing ... aam to can for this protective benefit ... there's a strong possibility in the short run that this is going to mean ... weekend screened women and risk much more effectively ... to determine on which women should take ... more extreme protective measures by eliminating ... women unless their risk appetite and saving them ... odds are taken the trouble of that that that many women who were iris a while the men of Lompoc in Oz the Jewish descent on the face because they have a higher ... likelihood of inheriting a the ... mutations can make more likely to get ... this cancer ... that ... in the longer run was interesting here says so much genetic research ... aam into cancers of all sorts of breast cancer in particular ... has focused understandably on finding ... genetic variations genetic mutations ... that put women at greater risk this is really the first time they've been able to find something that is so strongly protected ... and ... in the very long run if they can start to understand ... exactly what this genetic variation is doing they suspect it has something to do with regulating ... the production levels of the hormone estrogen ... which some forms of breast cancer of are much more aggressive that there's a higher level of estrogen ... on some forms of breast cancer ... aren't different ... but if they can nail that down it's quite possible in the very long run ... the sheep to use this is the basis for treatment that could possibly ... help all of those women ... with your family friends ... who did not inherit this variation I'll be very exciting thing that comes to pass thank you so much we for that ... what will really take a quick break and will be right back when lunch break in thirty seconds ... welcome back to lunch break I'm tiny Rivera oh any correctly pronouncing be our staff and is one of the most persistent speech problems for children ... but now an unlikely toil and ultrasound probe which is showing promise in helping them here with more on to our doubly SJ help Report or Sumathi Reddy Antara McAllister by an ... assistant professor at an might use Department of communication Sciences and disorders ... ladies thank you so much for being with us ... some of the let set with you how big of a speech problem is this ... incorrect pronunciation the R which words is it manifests itself at ... times used in all different sound like you know your kids say ... when instead of dragging out that's a very common one aam it's a ten percent kids have seen first Beacher sound disorder ... ours were most common one back to two percent of ... people in general population will have our problem persists ... and tell you work with and study these children where does the public companies attended the tinned a is it ... odd that Oreo ... the really good and sends exactly what causes speak some problems we know that there's an element of period where children are learning speech sounds and ... most children will ... converge on normal pronunciation within that period ... but for a subset of kids they're still persisting air ... and for those kids it may be that they don't really see it ... the distinction between the R sound and the area that they're making the right and that's not a one point is crucial to get help I understand that parents and talking about ... when Tyler about eight years old they get worried radical controversial my speech here be community and some people think he should lead to a twenty times the council was off on their on ... field think you know ... doing earlier that are sometimes it depends on the pair which I'll write an entire what's your opinion on that one to get treatment ... is absolutely depends on the family because ... all of these children coming roughly the same thing people think I talk to family where people are asking rent from and said talk of an accent ... for some kids that's a distinctive thing that they like but for other kids ... they may be reluctant to speak in social academic settings and so if it's causing a problem ... that's only try to provide the intervention and the this ultrasound probe that you've been working with how does it work exactly ... so obtuse and is ultra sound I it descends at an ultra sound wave that will reflect on when it encounters a change in intensity between different surfaces ... and if replace the probe underneath it and ... then we can actually get a reflection that will show us the shape and movement of the time ... Susman is also not be that the kids are getting that's explaining how the town is supposed to look when the sounds of May exactly occur miles she can rattle off and sort of ... thing ... is there some experimentation of all but just letting them make different shapes at that time and see what kind of sounds come out ... absolutely there is the isthe and experimentation peace and there's also modeling piece because the really difficult thing about this um like I is that it's hidden inside your mouth when you're talking ... and so you can show the child look at what I'm doing ... and so if we show them this is what might look like when I say are ... can you make it to look this nice that ... at some of that care is a step into another researchers say that this is a lot of comments yet had to go in if you renounce can really be used in research and there are few places that ... crinkly ... to pursue Cincinnati's tenants on an uber super squad and ... that's exciting and you are also conducting ... some research rate here in York City area cracking tell us about that that's correct yet the ultrasound research the Fed and pastas with colleagues that I Montclair State University who chairs the other right now I'm conducting ... some ... computer based treatment for children who have been our hair and how to respond to conventional forms of treatment ... and so if there are children in York City area ... that the use ... of free ... treatment program that uses some of these technologies that are actively looking for some that's that's great analogy has mock the thank so much to both of you for being with us ... a quick break and when we get back is there a pay gap of a different sort for women who run their own businesses will talk about that ... welcome back to lunch break I'm tiny Rivera oh the pay gap is the source object for many working women ... this that show women earn between ten and twenty five percent less than men across the U S workforce sch and this is one big reason many women need traditional career paths ... to start up their own businesses ... but once that I often find themselves up against a different kind of pay ... small business expert Susan Solomon is here to explain to them thank you so much ... for joining us ... so your saying more more win and leaving traditional careers to start their own businesses ... that's right time you actually when they are starting businesses that twice the rate of their male counterparts ... Souther about thirteen hundred new women owned businesses started every single day ... about nine point one million in the US in they account for one point four billion dollars in annual revenue huge market that very very exciting is that you say there is the kind of pain gap of sorts here can you explain ... this you would think if you're starting your own business that the ceiling of the land him the sky's the limit ... what we're seeing is that women owned businesses tend to stay small ... fewer than three percent ever crossed over the million dollar threshold ... sounds like a lot of money that when you're running a business there really isn't ... so what what we're finding is that these businesses are staying small ... and they're really not getting the growth capital that they need to build ... a significant companies ... on that and get a report called bridging the gender gap in venture capital ... they found that women owned businesses ... get only two point seven percent ... and venture capital and you know ... that's the kind of finding me that really propel Sarepta ... Rally so much cricket down why are women not getting the spot ... while there are a lot of reasons that personally I think there are two key things here one is ... there just aren't a lot of women business or what lot of women partner ... at venture capital firms and that the considerable amount of research ... that shows that ... men tend to find male oriented businesses that's a problem ... but also the process itself is very intimidating ... I embrace venture capital myself in fact in two thousandsix ... my company was selected as the best answer ... opportunity in the Silicom Valley but it is a process I scanned in nearly a year ... learning how to teach those PCs to talk their language and I he is an intimidating process educate women are less likely to just go out there and see this kind of ... I think that's the truth they don't understand it it's intimidating ... plus they don't have a lot of good role models to follow the law to women you're getting the VC money ... and as I said earlier not a lot of women in the DC for us we needed more when Anna Prior ay ay ay this bright spots though in terms of getting more funding to women ... you know I think the whole crowdfunding thing is a big bright spot for women ... in fact in the go Go's says in their statistics ... that about half of all their funded private projects are led by women ... and now they're a couple of sides that are just focused on women owned businesses one is called plum alley ... the other one is called moonlit who ... so I may yet you know women are good at making connections in making those relationships ... and so I believe that a little bit of a bright spot but we really need a lot more role models and a lot more effort to educate the market on how ... important is to give women these opportunities kept the lead role models RTN mentors thank you so much Susan Solomon than that ... and back How Marathon is sprinting to the front lines nearly two million people around the thirteen point one mile race last year making it one of the fastest growing and most popular races out there and win and make up over sixty percent of the participants here to tell us then on the rise of the half marathon is WSJ's Rachel Bachman Rachel thank the much for being with us to be here so the marathon how long has it been around and how fast is the thing growing What Silicon call the half marathons but the early nineteen eighties before that there were races at the same distance they were called that ... but it's really taken off since about two thousand has quadrupled in size since then in terms of the ships and what are some of the reasons it's become so popular ... I think it's the perfect sweet spot known and there was a very girly an arduous takes months and months and months to train for typically ... on the half marathon as Oval but shorter and easier to train for but still an achievement I mean certainly at thirteen miles nothing to sneeze that right ... and you think we men in particular ... are drawn to this race why is that yes I think one point is it's just last time the last time consuming if you how lot of things by New life Children's take care of for instance ... I it's very attractive but it's still an achievement she sports a way to stay in shape ... very easy does run out the door and taking it or not not not allow for two days after resuming will run a marathon is that they can get an ad for her to get it out for the Nasdaq so I mean now sorted teetering some of these races to win an absolutely that Tevez series for instance was good but unlike a feather boa in a row as the fence line the women's half marathon in sentences go tell by ninety ... on the of a Tiffany necklace advantage finds that deftly catering to women ... lots of travel on girls groups of three girls getaway weekends centered around half an hour but finds of the party is signing up is parting with exercise all sounds good ... but the hardcore runners but still look down on the half marathon I think there are not quite as arduous obviously on its defined by being half of something else ... and it's not in the Olympics it's not an Olympic distance of that takes away some machine announ high-profile elite runners they don't have the right is to come up with a different name instead of the half marathon maybe something like a thirty mile magnificent or something ... that's what you feel you know it as defined by its association with the map on which is a very sexy did distance and Andres to clicking right and ensure fewer people getting injured ... yes running one of the yes if you if you on the train properly then you're you're much less likely to have overuse injuries that are associate with the marathon which of course is a lot more check out the reason about my mates ... I've run one already nothing I read a two mile couple weekends ago in the Bronx and was beautifully without the love the idea ... that I can ... this ... might be within the range of pots ... that we think is the budget that ... didn't take a quick break and we come back the WSJ House of the weak same ... well it is Monday but we get some good news for you it's time for the doubly SJ house the weekend here with the contenders as Stefanos Chen from our Mansion team high seven s great to see how ... beautiful properties this week let's start with this guy views in mile high city ... yet this is great because you're already in Greece huge altitude in Denver but you're also on the forty fourth floor of the four Seasons ... residences here in the Denver ... at the unit itself is just under sixty two hundred square feet there's twenty foot tall ceilings in the green room ... basically like two two story living up there ... Piazza just miraculous so it's great that mean it's you can really see everything goes on for miles ... and has panoramic views ... there's also alot Syrian on the up stairs level this is really high and low condom living you have a in a hundred bottle wine cellar this will allow miraculous for seven million dollars on right now what happens Napa Valley estate without leaving you with pictures of yet this is great as it's nestled than that we always very famous ... vineyards and you have profits is forty acres there's a home with a three story tower with great views that the home that has that ... a win with billions in other games in guest rooms is a carotid to a two bedroom apartments in the space of family and friends ... outdoorsy that Bochy IRA which is awesome ... is an infinity pool there is that for tree orchard ... and the US have been great views of the non strangers they have what have they thought of guaranteed income of up to leave it there as are right that ... that would give the home of the former Philadelphia seventy six ers president gets a few big ... cities exist and this is the house for you it said the attack routes to ... was the president of the seventy six years ... as more and save ten thousand square feet and it's going up for auction actually in late October ... but you have the Selwood paddle from the wind in the area is gargoyles that are holding of beans ... the it's comical to see the owner is ... uncut of the idiocy Christie's is awesome is mermaids in the House of the cars ... and and that's actually less the market's six in the quarter met lots of details that somewhere says this outfit auction aren't there ... with more D tells the story but you'll see that it's going to auction on the twenty fifth rate now light and airy and the West Village has yet this is great because you have ... basically a gut it's crazy that they really did a great job with the idea of a ... new partner for the put in their new kitchen lamp dining living area ... it's got this ... the townhouse feel to it and of the bohemian ceremony I've yet seen the photos there were more stories is the finished basement skylights in the top four C got a lot of the natural way ... and if you to see that you've seen the photos there's very content for now I'm off the list is a Manhattan townhouse of my favorite ... I think that the Napa Valley misses the spectacular what did the viewer says he was a great year I ... pick out a record of properties that ... and think you so much that he meant English paper today I'm tiny Rivera oh thank you for watching stick around for opinion Journal Coming up at one p m Eastern ... we have to see Americans might have a great day ...