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Emerging research on the molecular etiology and pathogenesis of disease suggests that genetic diseases can be further partitioned into those that are heritable and those thought to arise from the accumulation of acquired genetic damage. This award is 26 Sclerosis designed to permit the PI to permanently leave his position as a radiation biologist, move into research and teaching in the field of aging full-time, receive training in subjects relevant to biodemographic research, and pursue a series of research projects associated with the training that initially focus on the biodemography of genetic diseases in humans.