361567 | GSK-3β Inhibitor XXIV - CAS 1005201-24-0 - Calbiochem

The GSK-3β Inhibitor XXIV, also referenced under CAS 1005201-24-0, controls the biological activity of GSK-3β. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

More>>The GSK-3β Inhibitor XXIV, also referenced under CAS 1005201-24-0, controls the biological activity of GSK-3β. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Less<<

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

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Description

Overview

The racemic mixture of a cell-permeable oxadiazolo-benzofuranylphenylsulfoxide that inhibits GSK-3β (IC50 = 35, 34, and 140 nM using the racemate, the (S), and the (R) enantiomer, respectively) in a highly selective manner. The eutomer is shown to be orally active in rats and mice and significantly reduce CWS-induced brain tau Thr205 phosphorylation in mice in vivo.

Documentation

SDS

References

Reference overview

Saitoh, M., et al. 2009. J. Med. Chem.52, 6270.

Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.