Invagination

Invagination is the infolding of one part within another part of a structure,[1] a folding that creates a pocket.[2] The term, originally used in embryology, has been adopted in other disciplines as well. It has many meanings in each term or subject.

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Invagination is the morphogenetic processes by which an embryo takes form, and is the initial step of gastrulation,[3] the massive reorganization of the embryo from a simple spherical ball of cells, the blastula, into a multi-layered organism, with differentiated germ layers: endoderm, mesoderm, and ectoderm. More localized invaginations also occur later in embryonic development,