GSK3beta Genetic Network

This paper has recently been accepted for publication after scientific peer-review! Here is a summary below and a link to the scientific article here.

Using a discovery and replication sample we replicated multiple two-SNP interactions with hippocampal volume in recurrent major depressive disorder (MDD). These replicable results involved variants in genes with functions relevant to depression, including endoplasmic reticulum stress, calcium regulation, and histone modifications. Our findings are relevant to cognitive impairments in depression and we speculate that micro RNA 124 and peroxisome proliferator-activated receptor-gamma and other related mechanisms play important roles.

This paper is a piece of the puzzle toward understanding the complex relationship between clinical administration of the drug, EPO, depression, cognition, hippocampal volume and underlying molecular mechanisms involving GSK3beta. More on the EPO story can be found here.