Description

If you live in the United States then it is still possible to buy Kinavet (licensed as Masivet in the UK) from VioVet.

We can accept a prescription from a US veterinary surgeon under a USDA permit obtained by VioVet. We have a template and description of the prescription process on our website here. We would need your vet to date, sign and stamp the prescription, which must also include pet details, product name, strength and dosage. We would recommend that you scan/photograph and then email your completed prescription from your vet to us on [email protected] or upload a file directly via your account on our website.

Orders must be placed by the owner of the dog being treated - we cannot supply veterinary surgeries with Masivet under any circumstances due to FDA / USDA regulations. We also require a specific written order from a licensed veterinarian stating that the animal should receive the unapproved product and provide a justification for the use of the unapproved drug. We also need an explanation as to why Masivet must be prescribed instead of an alternative medication.

We strongly recommend that you look into import regulations affecting you before placing an order. Royal Mail parcels are not routinely checked by customs but any regulations are applied by customs if they inspect a parcel. We will include all relevant documentation as required by our USDA Import Permit for Masivet with every order to smooth the importation process however the FDA may charge a $22.00 Adminsitration Fee for clearance of the documentation. This will be payable, if requested, to the UPS driver on delivery and is a Federal charge not a VioVet or UPS charge. Please be aware that Royal Mail Air Mail is an untracked service. We can offer delivery with UPS, which offers a tracking service and a quicker estimated delivery time, often under one week. The option for shipping with UPS will be available on orders only containing Masivet.

We can only send a maximum of a three month supply per animal per order. You will be contacted if your order exceeds this and your order will be amended to the appropriate quantity.

Orders can be placed on our website and payment can be made by card, PayPal or direct bank transfer (2.5% fee for for PayPal). Unfortunately we are unable to quote in US dollars- your card provider will be able to tell you the conversion rate they are currently using and will automatically take the correct amount for the payment.

If you would like any further information then email us at [email protected] and we'll do our best to help.

Masivet (licensed as Kinavet in the USA) is supplied as a tablet for use against a certain type of cancer affecting dogs. Masivet is regarded as safe enough to be used at home, and is given as a tablet once daily. It acts against mast cell tumours, by inhibiting cell division, therefore preventing further development of the tumours. Not all dogs respond, but the results can be very helpful for others. Close veterinary supervision is recommended at all times and Masivet is prescription only.

What is Masivet?

Masivet contains masitinib, which belongs to a class of medicines having an anti cancer action. It is available as round, orange tablets (50 and 150 mg).

What is Masivet used for?

Masivet is used to treat dogs with mast-cell tumours (a type of cancer). It is used for tumours which are severe in character (grade 2 or 3) and which cannot be removed with surgery. It is only used if the presence of a mutated form of the receptor protein c-kit in the tumours has been confirmed before the start of treatment. The tablets are given by mouth, once a day. The dose depends on the weight of the dog being treated.. The duration of treatment depends on the dog’s response to treatment.

How does Masivet work?

The active substance in Masivet, masitinib, is a protein-tyrosine kinase inhibitor. This means that it blocks some specific enzymes known astyrosine kinases. These enzymes can be found in some receptors on the surface of cells, including the c-kit receptor. Some types of mast-cell tumour are linked to a mutation that causes excessive action of c-kit and stimulates the mast cells to divide uncontrollably. By blocking these receptors, Masivet might help to control cell division, preventing further development of the tumours with this particular mutation.

How has Masivet been studied?

A number of studies with Masivet were carried out either in laboratory dogs or in animal patients at veterinary practises in Europe and in the USA. The main study compared the effectiveness of Masivet at the recommended dose of 12.5 mg per kilogramme bodyweight once a day with placebo (a dummy treatment). The study included dogs of various breeds and both sexes with mast-cell tumours that had come back after surgery or could not be removed with surgery. The study population included dogs whose tumours contained mutated ornormal (‘wild-type’) c-kit receptors.

What is the risk associated with Masivet?

The most common side effects with Masivet are gastrointestinal reactions (diarrhoea andvomiting) and hair loss. These reactions are usually mild to moderate and temporary, lasting for up to four weeks. Dogs under Masivet treatment should be regularly monitored for side effects by the veterinarian (at least monthly). In the case of side effects, the veterinarian might decide to lower the dose of Masivet or to discontinue treatment. Masivet must not be used in dogs with certain kinds of liver or kidney problems, or anaemia (low red blood cell counts) or neutropenia (low white blood cell counts). It must not be used in dogs less than six months of age or less than 4kg in weight, or bitches that are pregnant or lactating. It should not be used in dogs that may be hypersensitive (allergic) to masitinib or any of the other ingredients. For a full list of all side-effects reported with Masivet, see the Package Leaflet. Four to six weeks after starting the treatment with Masivet, the veterinarian should check if the treatment is likely to be successful.

What are the precautions for the person who gives the medicine or comes into contact with the animal?

The tablets must be administered whole and should not be divided, broken or ground up. If broken tablets, or the vomit, urine or faeces of a treated dog comes into contact with the skin or eyes, rinse immediately with plenty of water. Children should not have close contact with treated dogs, or their faeces or vomit. If Masivet is taken accidentally, seek medical advice immediately and show the Package Leaflet or the label to the doctor. Do not eat, drink or smoke while treating a dog. For more information, see the Package Leaflet.

Why has Masivet been approved?

The Committee for Medicinal Products for Veterinary Use (CVMP) concluded that the benefits of Masivet exceed the risks for the treatment of non-resectable mast cell tumours(grade 2 or 3) that have a confirmed mutated c-kit tyrosine kinase receptor and recommended that Masivet be given a marketing authorisation. The benefit-risk balance may be found inmodule 6 of this EPAR.

Other information about Masivet

The European Commission granted a marketing authorisation valid throughout the European Union, for Masivet to AB Science S.A. on 17 November 2008. Information on the prescription status of this product may be found on the label/outer package. Because this disease is a life threatening condition and the overall number ofdogs affected is expected to be low, the CVMP guidelines on “Minor-Use-Minor-Species (MUMS) data requirements” were applied when assessing the dossier.

4510 yr old bitch with mast cell tumours Verified Purchase

By Janice Payne on 7 March 2020

Ordered these tablets on advice from vet & with prescription from them as they would cost £600 plus from my vet! Much cheaper at £375 per month from Viovet. Lots of warnings on how to use and possible side effects but so far we haven’t seen any side effects and one large tumour has almost disappeared. Hasn’t stopped others appearing but will hopefully give us a few more months with our Phoebe

Customer recommends this product

55Impressed Verified Purchase

By Valerie Vickers on 1 May 2019

This product is amazing I was ready to put my baby down but after about 10 days of being on this shes acting like her old self .

Customer recommends this product

45Seems to work Verified Purchase

By Victoria Pruett on 31 March 2019

Only drug that’s seems to slow the recurrence of mast cell tumors. Also seems to shrink size so they’re a bit easier to remove.

Customer recommends this product

55Did exactly what I needed Verified Purchase

By Janet Hobday on 15 March 2019

Last year one of my dog's was diagnosed with a mast cell tumour on his hock, which our vet initially thought would be inoperable, because of where it was. He was put onto Masivet in the hope that it would shrink the tumour enough to enable the lump to be removed, and I am so glad and relieved to say that the Masivet did it's job. The lump did shrink and was ultimately removed. Dog did suffer minor side effects so we stopped the Masivet for a week while we got him checked out and he did finish the course of treatment with no further problems. I would have no hesitation in recommending Masivet and am keeping fingers crossed that we don't have to use it again.

Customer recommends this product

55Quick Positive Results Verified Purchase

By Geoffrey Cowling on 22 December 2018

Sad that any pet needs this medication but extremely good news that positive effects can be seen after just 14 days. No side effects seen.

MASIVET

Masivet must not be used in dogs less than six months of age or less than 4kg in weight. The dose rate is 12.5mg/kg once daily.

15 April 2016 at 8:55pm

Masitinib

Cheryl Woodring

VioVet customer since 2016

From: Washington, United States

Is this a generic drug for masitinib? I sent in a prescription and just want to make sure I'm paying for the correct one. I need the 150 mg not the 50 mg.

Dr. John Cousins BVSc MRCVS

VioVet Staff

The only brand name mastinib is sold under in the UK is Masivet. This is the original brand and not a generic. Other brand names can be chosen by the manufacturer when marketing it in other countries, but the product is the same. If your vet has prescribed mastinib, then Masivet is correct for you.